# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Phos_pyr_kin PF08543.7 EPA04243.1 - 1e-73 247.5 0.9 1e-73 247.5 0.6 1.4 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase Aldolase_2 PF10120.4 EPA04243.1 - 1.1e-55 187.6 0.1 2.2e-55 186.6 0.1 1.5 1 0 0 1 1 1 1 Putative aldolase PfkB PF00294.19 EPA04243.1 - 4.6e-12 45.6 0.0 6.4e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Carb_kinase PF01256.12 EPA04243.1 - 0.0024 17.1 0.5 0.0042 16.3 0.3 1.5 1 1 0 1 1 1 1 Carbohydrate kinase KH_5 PF13184.1 EPA04243.1 - 0.024 14.4 2.5 0.25 11.1 0.2 2.9 2 0 0 2 2 2 0 NusA-like KH domain Zn_Tnp_IS1595 PF12760.2 EPA04244.1 - 0.049 13.4 1.4 0.079 12.7 1.0 1.4 1 1 0 1 1 1 0 Transposase zinc-ribbon domain DUF4379 PF14311.1 EPA04244.1 - 0.078 12.7 0.4 0.11 12.2 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4379) Gemini_V1 PF01524.12 EPA04244.1 - 0.13 12.2 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Geminivirus V1 protein DUF4428 PF14471.1 EPA04244.1 - 0.28 10.9 3.0 0.95 9.2 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4428) C1_4 PF07975.7 EPA04244.1 - 0.32 11.0 1.9 0.41 10.6 1.3 1.1 1 0 0 1 1 1 0 TFIIH C1-like domain DUF367 PF04034.8 EPA04245.1 - 3.3e-36 123.6 0.0 4.6e-36 123.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 EPA04245.1 - 6.6e-07 28.7 0.1 1e-06 28.1 0.1 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI fn3 PF00041.16 EPA04248.1 - 7.6e-39 131.7 26.8 2.7e-15 56.2 4.1 4.2 4 0 0 4 4 4 4 Fibronectin type III domain SusE PF14292.1 EPA04248.1 - 2.8e-06 27.1 13.3 0.00013 21.7 2.1 3.7 2 1 1 3 3 3 2 SusE outer membrane protein ECR1_N PF14382.1 EPA04248.1 - 0.038 13.2 4.0 3.1 7.1 0.2 2.6 2 0 0 2 2 2 0 Exosome complex exonuclease RRP4 N-terminal region Reeler PF02014.11 EPA04248.1 - 0.085 13.1 6.0 3.1 8.0 0.2 3.3 2 1 1 3 3 3 0 Reeler domain ALAD PF00490.16 EPA04249.1 - 1.1e-66 224.9 0.3 1.2e-66 224.8 0.2 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase DUF2070 PF09843.4 EPA04249.1 - 0.0002 20.8 0.1 0.00023 20.7 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) GlutR_dimer PF00745.15 EPA04250.1 - 1.8e-06 27.8 0.0 2.1e-06 27.6 0.0 1.0 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain Coat_F PF07875.7 EPA04250.1 - 0.054 13.6 0.0 0.055 13.6 0.0 1.1 1 0 0 1 1 1 0 Coat F domain Sedlin_N PF04628.8 EPA04251.1 - 0.94 9.3 4.5 1.9 8.3 0.3 3.0 1 1 2 3 3 3 0 Sedlin, N-terminal conserved region Methyltransf_21 PF05050.7 EPA04252.1 - 2.7e-17 63.2 0.1 3.9e-17 62.7 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_18 PF12847.2 EPA04252.1 - 0.13 12.8 0.0 0.24 12.0 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Phlebovirus_NSM PF07246.6 EPA04253.1 - 0.046 12.8 1.2 0.062 12.4 0.9 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF4330 PF14221.1 EPA04253.1 - 0.071 12.9 2.4 4.5 7.1 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4330) BAAT_C PF08840.6 EPA04253.1 - 0.12 12.0 0.2 0.17 11.5 0.1 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Aminotran_1_2 PF00155.16 EPA04254.1 - 3.9e-41 141.2 0.0 5e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EPA04254.1 - 0.053 12.6 0.0 0.093 11.8 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase HEAT_2 PF13646.1 EPA04255.1 - 1.3e-12 47.8 0.1 3.3e-06 27.2 0.0 2.3 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.17 EPA04255.1 - 0.01 15.8 0.0 3.8 7.8 0.0 3.1 3 0 0 3 3 3 0 HEAT repeat COQ9 PF08511.6 EPA04255.1 - 0.044 13.3 0.0 0.084 12.3 0.0 1.5 1 0 0 1 1 1 0 COQ9 Cnd1 PF12717.2 EPA04255.1 - 0.096 12.5 0.0 0.2 11.4 0.0 1.6 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 TrmB PF01978.14 EPA04257.1 - 0.0046 16.6 0.0 0.014 15.0 0.0 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB DUF3335 PF11814.3 EPA04257.1 - 0.13 11.3 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase_C39 like family Mga PF05043.8 EPA04257.1 - 0.16 12.3 2.8 0.96 9.7 0.0 2.7 3 2 0 3 3 3 0 Mga helix-turn-helix domain DUF2387 PF09526.5 EPA04258.1 - 0.0021 17.9 0.6 0.0028 17.5 0.4 1.2 1 0 0 1 1 1 1 Probable metal-binding protein (DUF2387) zf-FPG_IleRS PF06827.9 EPA04258.1 - 0.0049 16.4 1.1 0.17 11.5 0.1 2.3 2 0 0 2 2 2 1 Zinc finger found in FPG and IleRS DUF3268 PF11672.3 EPA04258.1 - 0.032 14.2 0.1 0.037 14.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3268) Lar_restr_allev PF14354.1 EPA04258.1 - 0.068 13.4 0.1 0.085 13.1 0.0 1.2 1 0 0 1 1 1 0 Restriction alleviation protein Lar DZR PF12773.2 EPA04258.1 - 0.092 12.5 1.1 0.24 11.2 0.8 1.6 1 1 0 1 1 1 0 Double zinc ribbon Cys_rich_KTR PF14205.1 EPA04258.1 - 0.54 9.7 4.4 1.6 8.2 2.5 2.0 1 1 1 2 2 2 0 Cysteine-rich KTR DUF1297 PF06973.7 EPA04259.1 - 5.2e-12 45.4 0.1 5.3e-12 45.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) A2L_zn_ribbon PF08792.5 EPA04260.1 - 2.9 7.4 5.9 0.62 9.6 0.9 2.2 1 1 1 2 2 2 0 A2L zinc ribbon domain Peptidase_M50 PF02163.17 EPA04261.1 - 2.9e-25 88.3 0.0 1.5e-24 85.9 0.0 2.0 1 1 0 1 1 1 1 Peptidase family M50 PDZ_2 PF13180.1 EPA04261.1 - 1.2e-09 37.8 0.0 2.2e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 EPA04261.1 - 0.00043 20.3 0.0 0.0009 19.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) ATP_bind_3 PF01171.15 EPA04262.1 - 1.3e-17 63.9 0.0 1.9e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.11 EPA04262.1 - 2.3e-05 23.1 0.0 3.1e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.8 EPA04262.1 - 0.003 16.8 0.2 0.0078 15.5 0.0 1.8 1 1 1 2 2 2 1 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.14 EPA04262.1 - 0.027 14.3 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Ribosomal_S14 PF00253.16 EPA04262.1 - 5.2 6.5 7.0 0.42 10.0 0.9 2.0 2 0 0 2 2 2 0 Ribosomal protein S14p/S29e Response_reg PF00072.19 EPA04263.1 - 7.1e-24 83.9 2.7 7.9e-24 83.8 1.8 1.0 1 0 0 1 1 1 1 Response regulator receiver domain FleQ PF06490.6 EPA04263.1 - 0.013 15.5 0.2 0.025 14.7 0.1 1.7 1 1 0 1 1 1 0 Flagellar regulatory protein FleQ B12-binding PF02310.14 EPA04263.1 - 0.017 14.9 0.0 0.031 14.1 0.0 1.4 1 1 0 1 1 1 0 B12 binding domain TrkA_N PF02254.13 EPA04263.1 - 0.066 13.2 2.0 0.15 12.1 1.4 1.6 1 1 0 1 1 1 0 TrkA-N domain bPH_3 PF14470.1 EPA04265.1 - 0.00073 19.7 0.5 0.069 13.4 0.0 2.4 2 0 0 2 2 2 2 Bacterial PH domain DNA_pol_E_B PF04042.11 EPA04266.1 - 2.4e-11 43.3 0.0 3.9e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Metallophos PF00149.23 EPA04266.1 - 7.3e-07 28.7 0.0 1.5e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EPA04266.1 - 3.1e-05 23.8 0.0 5.1e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF2326 PF10088.4 EPA04266.1 - 0.031 13.8 0.9 0.069 12.7 0.6 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2326) Med15_fungi PF05397.7 EPA04266.1 - 0.04 13.8 0.4 0.37 10.7 0.0 2.2 2 0 0 2 2 2 0 Mediator complex subunit 15 tRNA_anti-codon PF01336.20 EPA04266.1 - 0.043 13.6 0.1 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain TP_methylase PF00590.15 EPA04267.1 - 2.6e-36 125.3 0.0 2.9e-36 125.1 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF95 PF01944.12 EPA04268.1 - 1.1e-09 38.1 8.1 1.4e-09 37.8 5.6 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF95 Copper-bind PF00127.15 EPA04269.1 - 0.057 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family Pro_isomerase PF00160.16 EPA04270.1 - 3.5e-49 166.9 0.4 7.4e-49 165.9 0.3 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SLEI_Leptospira PF07620.6 EPA04270.1 - 0.17 11.7 0.7 0.38 10.6 0.5 1.6 1 0 0 1 1 1 0 SLEI FtsX PF02687.16 EPA04272.1 - 0.14 11.8 1.6 0.31 10.8 1.1 1.6 1 1 0 1 1 1 0 FtsX-like permease family HHH_5 PF14520.1 EPA04273.1 - 2e-12 47.0 0.4 3.3e-12 46.3 0.3 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.2 EPA04273.1 - 2.4e-06 27.3 0.1 9.8e-06 25.3 0.0 2.0 1 1 1 2 2 2 1 Helix-hairpin-helix motif DNA_pol_lambd_f PF10391.4 EPA04273.1 - 1.7e-05 24.2 0.0 3.5e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DUF4332 PF14229.1 EPA04273.1 - 0.009 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) HHH_8 PF14716.1 EPA04273.1 - 0.011 15.8 0.1 0.45 10.7 0.1 2.3 1 1 1 2 2 2 0 Helix-hairpin-helix domain HHH PF00633.18 EPA04273.1 - 0.016 14.8 0.0 0.12 12.0 0.0 2.5 3 0 0 3 3 3 0 Helix-hairpin-helix motif RNA_pol_A_CTD PF03118.10 EPA04273.1 - 0.023 14.1 0.2 0.08 12.3 0.1 2.0 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain Cdd1 PF11731.3 EPA04273.1 - 0.044 13.6 0.1 0.14 12.0 0.0 1.9 1 1 0 1 1 1 0 Pathogenicity locus TfoX_C PF04994.8 EPA04273.1 - 0.13 12.1 0.2 0.44 10.4 0.0 2.0 2 1 0 2 2 2 0 TfoX C-terminal domain Polysacc_deac_1 PF01522.16 EPA04274.1 - 0.00026 20.6 0.0 0.00055 19.5 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase EPSP_synthase PF00275.15 EPA04275.1 - 2.3e-101 339.2 0.0 2.8e-101 338.9 0.0 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) HATPase_c PF02518.21 EPA04276.1 - 4.3e-18 65.0 0.0 7.4e-18 64.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.1 EPA04276.1 - 1.1e-07 31.4 0.1 2.4e-07 30.4 0.0 1.6 2 0 0 2 2 2 1 GHKL domain HATPase_c_2 PF13581.1 EPA04276.1 - 0.0041 16.9 0.0 0.0087 15.8 0.0 1.5 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain DUF2935 PF11155.3 EPA04276.1 - 0.052 13.6 0.1 0.072 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Chorismate_synt PF01264.16 EPA04277.1 - 2.5e-16 59.1 0.0 2.7e-16 59.0 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase PAS_9 PF13426.1 EPA04278.1 - 2e-16 60.2 0.0 2.5e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.5 EPA04278.1 - 2.6e-08 33.8 0.0 3.3e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 PAS fold PAS PF00989.19 EPA04278.1 - 1.7e-07 31.0 0.0 2.3e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.1 EPA04278.1 - 7.4e-07 28.8 0.0 1.3e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.6 EPA04278.1 - 1.8e-05 24.7 0.0 2.5e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.1 EPA04278.1 - 0.0057 16.5 0.0 0.0086 16.0 0.0 1.3 1 0 0 1 1 1 1 PAS domain GHMP_kinases_N PF00288.21 EPA04279.1 - 1.3e-11 44.4 0.4 2.2e-11 43.6 0.3 1.4 1 0 0 1 1 1 1 GHMP kinases N terminal domain Aminotran_1_2 PF00155.16 EPA04280.1 - 5.7e-20 71.5 0.1 7.6e-20 71.1 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EPA04280.1 - 0.0022 17.2 0.0 0.003 16.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 EPA04280.1 - 0.015 13.5 0.0 0.019 13.2 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Ribosomal_S30AE PF02482.14 EPA04280.1 - 0.27 11.6 3.6 0.13 12.6 0.6 1.9 2 1 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein DUF3781 PF12636.2 EPA04280.1 - 1 9.3 6.5 1.7 8.6 0.2 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3781) LemA PF04011.7 EPA04281.1 - 7e-52 175.2 0.2 8.3e-52 174.9 0.1 1.0 1 0 0 1 1 1 1 LemA family DUF479 PF04336.7 EPA04281.1 - 0.0093 16.0 0.3 0.013 15.6 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF479 YkyA PF10368.4 EPA04281.1 - 0.013 14.8 1.5 0.023 14.0 1.0 1.3 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein Chordopox_A13L PF05961.6 EPA04281.1 - 0.065 13.1 1.4 0.15 12.0 0.9 1.6 1 0 0 1 1 1 0 Chordopoxvirus A13L protein SurA_N_3 PF13624.1 EPA04281.1 - 0.087 12.7 0.6 0.13 12.2 0.4 1.4 1 0 0 1 1 1 0 SurA N-terminal domain DUF3139 PF11337.3 EPA04281.1 - 0.091 13.0 2.1 2.3 8.5 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Ribosomal_L36e PF01158.13 EPA04281.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L36e MacB_PCD PF12704.2 EPA04281.1 - 5.5 6.5 7.6 19 4.7 5.3 1.8 1 1 0 1 1 1 0 MacB-like periplasmic core domain Response_reg PF00072.19 EPA04282.1 - 1e-18 67.3 0.0 2e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain ArsC PF03960.10 EPA04282.1 - 0.00045 20.2 1.6 0.0016 18.5 1.1 2.0 1 0 0 1 1 1 1 ArsC family HCV_NS1 PF01560.12 EPA04282.1 - 0.03 12.7 1.5 0.046 12.1 1.1 1.1 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein E2/NS1 zf-Di19 PF05605.7 EPA04282.1 - 0.051 13.7 4.4 0.15 12.2 3.0 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zinc-ribbons_6 PF07191.7 EPA04282.1 - 0.08 12.7 14.2 0.75 9.6 3.3 3.1 1 1 2 3 3 3 0 zinc-ribbons HTH_11 PF08279.7 EPA04282.1 - 0.12 12.0 0.5 0.34 10.5 0.3 1.8 1 0 0 1 1 1 0 HTH domain DZR PF12773.2 EPA04282.1 - 0.14 11.9 15.2 0.31 10.8 1.7 3.0 1 1 1 2 2 2 0 Double zinc ribbon zf-C3HC4_3 PF13920.1 EPA04282.1 - 0.27 10.9 11.2 7.9 6.2 0.7 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) HypA PF01155.14 EPA04282.1 - 0.33 10.6 15.1 0.72 9.5 0.2 3.7 1 1 2 3 3 3 0 Hydrogenase expression/synthesis hypA family zf-P11 PF03854.9 EPA04282.1 - 1.4 8.4 16.3 3.9 7.0 1.3 3.6 2 1 1 3 3 3 0 P-11 zinc finger zf-FPG_IleRS PF06827.9 EPA04282.1 - 1.4 8.6 12.7 2.3 7.9 0.9 3.7 2 1 1 3 3 3 0 Zinc finger found in FPG and IleRS DnaJ_CXXCXGXG PF00684.14 EPA04282.1 - 2.3 8.3 14.9 3.4 7.7 3.6 3.0 1 1 2 3 3 3 0 DnaJ central domain ZZ PF00569.12 EPA04282.1 - 3.8 7.1 12.1 1.2 8.7 1.8 3.0 2 1 0 2 2 2 0 Zinc finger, ZZ type Spt4 PF06093.8 EPA04282.1 - 7.4 6.5 19.4 0.51 10.2 0.2 3.8 3 1 1 4 4 4 0 Spt4/RpoE2 zinc finger Aminotran_3 PF00202.16 EPA04283.1 - 7.3e-81 271.6 0.0 8.9e-81 271.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 EPA04283.1 - 0.00022 20.4 0.0 0.00035 19.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 EPA04283.1 - 0.047 12.6 0.0 0.091 11.7 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Ribosomal_L1 PF00687.16 EPA04283.1 - 0.097 11.9 0.9 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L1p/L10e family Thioredoxin_4 PF13462.1 EPA04286.1 - 7.6e-37 126.8 0.1 1e-36 126.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.15 EPA04286.1 - 3.8e-18 65.7 0.1 4.7e-17 62.1 0.1 2.0 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.1 EPA04286.1 - 7.6e-08 32.5 0.2 4.2e-07 30.1 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EPA04286.1 - 0.0019 18.2 0.2 2 8.5 0.1 2.3 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_5 PF13743.1 EPA04286.1 - 0.0063 16.0 0.0 0.0095 15.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin SinI PF08671.5 EPA04286.1 - 0.16 11.4 0.0 2.3 7.6 0.0 2.3 2 0 0 2 2 2 0 Anti-repressor SinI AAA_26 PF13500.1 EPA04287.1 - 1.6e-15 57.2 0.0 1.8e-15 57.1 0.0 1.0 1 0 0 1 1 1 1 AAA domain ParA PF10609.4 EPA04287.1 - 0.07 13.0 1.8 0.11 12.4 1.1 1.4 1 1 0 1 1 1 0 ParA/MinD ATPase like Aminotran_1_2 PF00155.16 EPA04288.1 - 4.1e-21 75.3 0.0 4.5e-21 75.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II AAA_26 PF13500.1 EPA04289.1 - 1.3e-12 47.7 0.0 1.3e-12 47.7 0.0 1.0 1 0 0 1 1 1 1 AAA domain CbiA PF01656.18 EPA04289.1 - 5.8e-05 22.5 0.0 5.8e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF1611 PF07755.6 EPA04289.1 - 0.15 10.6 0.1 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1611) TPM PF04536.9 EPA04290.1 - 1.2e-11 44.5 0.0 2.9e-11 43.2 0.0 1.6 1 1 0 1 1 1 1 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase ETRAMP PF09716.5 EPA04290.1 - 0.038 13.9 0.1 0.066 13.1 0.1 1.6 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Anophelin PF10731.4 EPA04290.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito HMG_CoA_synt_C PF08540.5 EPA04291.1 - 4.7e-31 108.3 0.1 1.3e-30 106.8 0.1 1.6 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.12 EPA04291.1 - 1.2e-30 106.4 0.2 1.9e-30 105.7 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Guanylate_kin PF00625.16 EPA04292.1 - 0.48 9.8 4.3 0.59 9.5 1.6 1.8 2 0 0 2 2 2 0 Guanylate kinase RCR PF12273.3 EPA04293.1 - 0.17 12.4 0.9 0.21 12.1 0.6 1.1 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red BATS PF06968.8 EPA04294.1 - 1.3e-22 79.4 0.0 3.5e-22 78.0 0.0 1.8 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.16 EPA04294.1 - 1.4e-17 64.4 0.5 3.4e-17 63.1 0.2 1.7 2 0 0 2 2 2 1 Radical SAM superfamily Neurokinin_B PF03823.9 EPA04294.1 - 0.16 11.7 0.0 2.9 7.7 0.0 2.6 3 0 0 3 3 3 0 Neurokinin B DUF1743 PF08489.6 EPA04295.1 - 9.4e-14 51.1 0.0 1e-13 51.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1743) DUF1743 PF08489.6 EPA04297.1 - 1.2e-07 31.5 0.1 1.2e-07 31.4 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1743) UPF0147 PF03685.8 EPA04298.1 - 1.3e-32 111.4 2.8 1.5e-32 111.3 2.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0147) UPF0253 PF06786.7 EPA04298.1 - 0.002 18.2 0.0 1.2 9.2 0.0 2.4 1 1 0 2 2 2 2 Uncharacterised protein family (UPF0253) Bacillus_HBL PF05791.6 EPA04298.1 - 0.0024 17.2 1.2 0.0024 17.2 0.8 1.2 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) Glyco_hydro_20b PF02838.10 EPA04298.1 - 0.019 15.5 0.6 0.023 15.2 0.4 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 DUF2262 PF10020.4 EPA04298.1 - 0.047 13.8 0.4 0.047 13.8 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2262) DUF3461 PF11944.3 EPA04298.1 - 0.091 12.6 0.4 0.67 9.7 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) UvrB PF12344.3 EPA04298.1 - 0.45 10.0 2.1 1.5 8.4 0.2 2.2 2 0 0 2 2 2 0 Ultra-violet resistance protein B Rieske PF00355.21 EPA04299.1 - 1.5e-16 59.7 0.0 1.8e-16 59.4 0.0 1.0 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 EPA04299.1 - 5.1e-08 32.5 0.0 5.9e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain tRNA-synt_1c PF00749.16 EPA04300.1 - 1.6e-76 256.9 0.0 2.7e-76 256.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 EPA04300.1 - 2.5e-22 79.3 0.1 5.2e-22 78.3 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain FAA_hydrolase PF01557.13 EPA04301.1 - 5e-67 225.5 0.0 6.5e-67 225.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF2437 PF10370.4 EPA04301.1 - 0.00014 22.1 0.2 0.00078 19.7 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF2437) Methyltransf_31 PF13847.1 EPA04302.1 - 7e-06 25.7 0.3 1.5e-05 24.5 0.1 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA04302.1 - 1.9e-05 25.0 0.0 4.6e-05 23.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain DOT1 PF08123.8 EPA04302.1 - 3.2e-05 23.3 0.0 4.7e-05 22.7 0.0 1.2 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_25 PF13649.1 EPA04302.1 - 4e-05 23.8 0.0 5.5e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA04302.1 - 7.7e-05 23.2 0.0 9.2e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 EPA04302.1 - 0.0012 18.1 0.1 0.0013 17.9 0.1 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_4 PF02390.12 EPA04302.1 - 0.0037 16.3 0.2 0.0038 16.2 0.1 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.7 EPA04302.1 - 0.006 17.0 0.0 0.0092 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EPA04302.1 - 0.0082 15.2 0.0 0.0095 15.0 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.9 EPA04302.1 - 0.024 14.0 0.0 0.028 13.7 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_5 PF01795.14 EPA04302.1 - 0.032 13.5 0.0 0.039 13.2 0.0 1.1 1 0 0 1 1 1 0 MraW methylase family PA-IIL PF07472.6 EPA04302.1 - 0.036 14.2 0.0 0.044 13.9 0.0 1.2 1 0 0 1 1 1 0 Fucose-binding lectin II (PA-IIL) TrkA_N PF02254.13 EPA04302.1 - 0.04 13.9 0.0 0.056 13.4 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain Propep_M14 PF02244.11 EPA04302.1 - 0.099 12.3 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Carboxypeptidase activation peptide Acetyltransf_7 PF13508.1 EPA04303.1 - 3.2e-07 30.4 0.1 1.2e-06 28.6 0.0 1.9 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EPA04303.1 - 9.5e-07 28.7 0.0 2.8e-06 27.2 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EPA04303.1 - 7.2e-05 22.4 0.0 0.00016 21.3 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.1 EPA04303.1 - 0.00052 20.1 0.1 0.00091 19.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TaqI_C PF12950.2 EPA04303.1 - 0.0066 16.1 1.0 0.0066 16.1 0.7 1.8 2 1 0 2 2 2 1 TaqI-like C-terminal specificity domain Acetyltransf_10 PF13673.1 EPA04303.1 - 0.013 15.5 0.0 0.12 12.5 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Gly_acyl_tr_C PF08444.5 EPA04303.1 - 0.064 13.2 0.7 0.21 11.6 0.0 2.1 2 0 0 2 2 2 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region FmdE PF02663.9 EPA04303.1 - 0.086 12.7 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Acetyltransf_9 PF13527.1 EPA04303.1 - 0.14 12.0 0.0 0.57 10.0 0.0 2.1 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain ALAD PF00490.16 EPA04304.1 - 2.7e-64 217.1 0.6 2.9e-64 216.9 0.4 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase DUF1446 PF07287.6 EPA04304.1 - 0.024 13.1 0.0 0.032 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1446) Mgr1 PF08602.5 EPA04305.1 - 0.0089 15.0 1.3 0.011 14.8 0.9 1.0 1 0 0 1 1 1 1 Mgr1-like, i-AAA protease complex subunit DUF2833 PF11090.3 EPA04305.1 - 0.023 14.8 2.2 0.028 14.5 0.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2833) IMS PF00817.15 EPA04305.1 - 0.041 13.6 0.1 0.043 13.6 0.1 1.1 1 0 0 1 1 1 0 impB/mucB/samB family RNA_pol_Rpb4 PF03874.11 EPA04305.1 - 0.05 13.6 1.4 0.059 13.3 0.8 1.4 1 1 0 1 1 1 0 RNA polymerase Rpb4 G6PD_N PF00479.17 EPA04305.1 - 0.078 13.2 0.6 0.087 13.0 0.4 1.1 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, NAD binding domain Ribosomal_S7e PF01251.13 EPA04305.1 - 0.079 12.4 0.8 0.1 12.0 0.5 1.3 1 1 0 1 1 1 0 Ribosomal protein S7e DUF1896 PF08989.5 EPA04305.1 - 0.089 12.6 0.5 0.13 12.1 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1896) Spore_GerAC PF05504.6 EPA04305.1 - 0.44 10.3 4.3 0.2 11.4 0.9 1.7 1 1 1 2 2 2 0 Spore germination B3/ GerAC like, C-terminal DNA_pol3_delta2 PF13177.1 EPA04306.1 - 6.4e-17 61.6 1.8 5.3e-15 55.4 0.2 2.6 2 1 0 2 2 2 1 DNA polymerase III, delta subunit AAA PF00004.24 EPA04306.1 - 1e-12 48.4 0.9 2e-12 47.4 0.1 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.6 EPA04306.1 - 4.8e-12 45.6 2.7 6e-12 45.3 0.4 2.1 2 0 0 2 2 2 1 Replication factor C C-terminal domain Rad17 PF03215.10 EPA04306.1 - 1.3e-08 34.0 0.1 0.00068 18.4 0.1 2.4 1 1 1 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_14 PF13173.1 EPA04306.1 - 4.5e-06 26.5 0.0 9.7e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EPA04306.1 - 1.1e-05 25.5 0.9 0.04 14.0 0.0 2.5 1 1 1 2 2 2 2 AAA domain DNA_pol3_delta PF06144.8 EPA04306.1 - 2.4e-05 23.9 0.8 5.6e-05 22.7 0.1 1.8 2 0 0 2 2 2 1 DNA polymerase III, delta subunit RuvB_N PF05496.7 EPA04306.1 - 3.2e-05 23.0 0.0 0.0001 21.4 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_3 PF07726.6 EPA04306.1 - 0.00021 20.8 0.0 0.0004 19.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EPA04306.1 - 0.00046 20.2 0.1 0.059 13.3 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain DEAD PF00270.24 EPA04306.1 - 0.0038 16.7 0.6 0.27 10.6 0.0 2.4 1 1 1 2 2 2 1 DEAD/DEAH box helicase Mg_chelatase PF01078.16 EPA04306.1 - 0.0073 15.4 0.0 0.53 9.4 0.0 2.6 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI PhoH PF02562.11 EPA04306.1 - 0.0088 15.3 0.2 1.8 7.7 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein AAA_10 PF12846.2 EPA04306.1 - 0.0089 15.4 2.3 0.43 9.9 1.6 2.5 1 1 0 1 1 1 1 AAA-like domain AAA_19 PF13245.1 EPA04306.1 - 0.013 15.2 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain ResIII PF04851.10 EPA04306.1 - 0.027 14.2 0.4 0.24 11.2 0.3 2.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit PTPlike_phytase PF14566.1 EPA04306.1 - 0.037 14.0 0.3 0.12 12.3 0.0 2.0 2 1 0 2 2 2 0 Inositol hexakisphosphate AAA_18 PF13238.1 EPA04306.1 - 0.042 14.1 1.1 0.21 11.8 0.1 2.4 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.17 EPA04306.1 - 0.061 12.1 0.4 0.19 10.5 0.0 2.1 2 1 0 2 2 2 0 NB-ARC domain AAA_5 PF07728.9 EPA04306.1 - 0.088 12.5 0.6 0.98 9.1 0.4 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.1 EPA04306.1 - 0.098 12.6 0.1 4.3 7.3 0.0 2.8 2 1 0 2 2 2 0 Sigma-54 interaction domain DEAD PF00270.24 EPA04307.1 - 1.8e-14 53.5 0.0 2.1e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 EPA04307.1 - 0.00049 19.9 0.0 0.00058 19.7 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SE PF00437.15 EPA04307.1 - 0.0014 17.5 0.0 0.0016 17.4 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.1 EPA04307.1 - 0.02 14.6 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Part of AAA domain AAA_25 PF13481.1 EPA04307.1 - 0.022 14.1 0.0 0.026 13.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain Zot PF05707.7 EPA04307.1 - 0.043 13.2 0.0 0.061 12.7 0.0 1.2 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) PhoH PF02562.11 EPA04307.1 - 0.092 11.9 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 PhoH-like protein Helicase_C PF00271.26 EPA04308.1 - 3.7e-11 42.7 0.0 8.3e-11 41.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EPA04308.1 - 2.8e-09 36.6 0.6 6e-09 35.6 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase MCM PF00493.18 EPA04309.1 - 2.2e-126 421.1 0.1 3e-126 420.7 0.1 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 EPA04309.1 - 3.6e-15 56.5 0.5 2.2e-14 54.0 0.1 2.4 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.9 EPA04309.1 - 1.2e-06 28.3 0.0 2e-05 24.3 0.0 2.8 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 EPA04309.1 - 2.4e-06 26.8 0.1 0.00019 20.6 0.0 2.5 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 EPA04309.1 - 0.00098 18.7 0.0 0.0032 17.0 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) HATPase_c PF02518.21 EPA04310.1 - 4.4e-24 84.3 0.2 2e-23 82.2 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3068 PF11271.3 EPA04310.1 - 1.6e-11 43.8 0.2 3e-11 42.9 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3068) HisKA PF00512.20 EPA04310.1 - 6.6e-10 38.8 0.1 1.5e-09 37.7 0.1 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.1 EPA04310.1 - 7.2e-09 35.2 0.9 3.4e-08 33.1 0.0 2.4 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.1 EPA04310.1 - 8.1e-05 22.2 0.3 0.00023 20.8 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 EPA04310.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain DUF2328 PF10090.4 EPA04310.1 - 0.042 13.0 0.1 0.36 9.9 0.1 2.2 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2328) PspB PF06667.7 EPA04310.1 - 0.072 13.0 1.2 0.13 12.1 0.1 2.0 2 0 0 2 2 2 0 Phage shock protein B Fer4_8 PF13183.1 EPA04311.1 - 4.5e-10 39.4 11.3 1.8e-08 34.2 3.4 1.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.2 EPA04311.1 - 4.9e-10 39.6 1.3 0.00054 20.2 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.22 EPA04311.1 - 2.1e-09 36.5 8.2 0.0002 20.8 1.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.1 EPA04311.1 - 2.8e-08 33.4 2.8 0.0011 18.8 0.6 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.1 EPA04311.1 - 8.1e-08 32.4 6.9 2.7e-07 30.7 4.7 1.9 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 EPA04311.1 - 2.8e-07 30.2 8.3 4.3e-06 26.4 6.3 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.1 EPA04311.1 - 1.1e-06 28.9 2.7 2.1e-06 27.9 1.9 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.2 EPA04311.1 - 1e-05 25.1 9.7 0.011 15.5 2.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.1 EPA04311.1 - 5.5e-05 23.6 4.8 0.022 15.3 0.1 2.6 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_16 PF13484.1 EPA04311.1 - 7.7e-05 23.3 8.3 0.0039 17.8 6.6 2.3 1 1 2 3 3 3 3 4Fe-4S double cluster binding domain Fer4_18 PF13746.1 EPA04311.1 - 9.7e-05 22.7 8.9 0.00023 21.5 4.7 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.2 EPA04311.1 - 9.9e-05 22.0 10.3 0.0083 15.9 0.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.1 EPA04311.1 - 0.00015 22.0 5.1 0.16 12.3 0.2 2.6 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_4 PF12800.2 EPA04311.1 - 0.00049 20.2 8.3 0.26 11.7 2.0 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_3 PF12798.2 EPA04311.1 - 0.0031 17.9 13.8 0.13 12.8 3.6 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain DUF2761 PF10959.3 EPA04311.1 - 0.097 12.3 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2761) Sld5 PF05916.6 EPA04312.1 - 2e-09 37.7 0.8 2.5e-09 37.3 0.6 1.2 1 0 0 1 1 1 1 GINS complex protein EamA PF00892.15 EPA04314.1 - 4.7e-15 55.7 15.8 5.7e-15 55.4 10.9 1.0 1 0 0 1 1 1 1 EamA-like transporter family EmrE PF13536.1 EPA04314.1 - 2.7e-05 24.3 17.4 0.00012 22.2 11.7 1.8 1 1 1 2 2 2 1 Multidrug resistance efflux transporter ATP_bind_1 PF03029.12 EPA04314.1 - 0.051 13.1 0.0 0.068 12.6 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Response_reg PF00072.19 EPA04315.1 - 9.5e-24 83.5 0.7 1.1e-23 83.4 0.5 1.0 1 0 0 1 1 1 1 Response regulator receiver domain 2-Hacid_dh_C PF02826.14 EPA04315.1 - 0.0029 16.7 0.0 0.0035 16.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Alba PF01918.16 EPA04315.1 - 0.041 13.4 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 Alba DXP_reductoisom PF02670.11 EPA04315.1 - 0.14 12.7 0.1 1.1 9.7 0.0 1.9 1 1 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Peptidase_S24 PF00717.18 EPA04318.1 - 6.4e-09 35.3 0.4 1.2e-08 34.5 0.3 1.4 1 0 0 1 1 1 1 Peptidase S24-like DUF202 PF02656.10 EPA04318.1 - 0.0067 16.6 6.1 0.26 11.5 1.1 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF202) DUF606 PF04657.8 EPA04318.1 - 0.0077 16.3 3.9 0.024 14.6 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF606 DUF1129 PF06570.6 EPA04318.1 - 0.061 12.6 11.0 0.48 9.7 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) Claudin_2 PF13903.1 EPA04318.1 - 0.17 11.5 6.4 0.12 12.0 3.1 1.7 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF1686 PF07937.6 EPA04318.1 - 0.18 11.3 2.8 1.9 8.0 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1686) O-antigen_lig PF13425.1 EPA04318.1 - 1.8 8.5 20.6 8.8 6.3 6.9 3.1 2 1 1 3 3 3 0 O-antigen ligase like membrane protein EamA PF00892.15 EPA04319.1 - 0.046 13.7 0.5 0.19 11.7 0.1 1.8 1 1 1 2 2 2 0 EamA-like transporter family YGGT PF02325.12 EPA04319.1 - 0.056 13.3 0.1 0.067 13.1 0.1 1.2 1 0 0 1 1 1 0 YGGT family DUF721 PF05258.7 EPA04321.1 - 0.018 15.2 0.0 0.031 14.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF721) Sar8_2 PF03058.9 EPA04321.1 - 0.055 13.8 0.0 0.087 13.1 0.0 1.4 1 0 0 1 1 1 0 Sar8.2 family DUF4352 PF11611.3 EPA04322.1 - 0.0023 18.0 0.4 0.0033 17.5 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4352) Thioredoxin_4 PF13462.1 EPA04323.1 - 1.2e-35 122.9 0.0 1.6e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.15 EPA04323.1 - 2e-12 47.0 0.1 3.9e-11 42.8 0.0 2.1 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.1 EPA04323.1 - 2.1e-08 34.3 0.0 6.6e-08 32.7 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EPA04323.1 - 0.0015 18.6 0.3 0.1 12.7 0.2 2.4 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_5 PF13743.1 EPA04323.1 - 0.03 13.8 0.0 0.046 13.2 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin DUF3185 PF11381.3 EPA04323.1 - 0.092 12.5 0.6 0.2 11.4 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) MacB_PCD PF12704.2 EPA04324.1 - 0.098 12.2 1.8 5 6.6 1.5 2.1 1 1 1 2 2 2 0 MacB-like periplasmic core domain eIF-5a PF01287.15 EPA04325.1 - 2e-13 50.0 1.2 2.8e-13 49.6 0.8 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.7 EPA04325.1 - 9.7e-05 22.1 0.1 0.0035 17.1 0.0 2.2 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain KOW PF00467.24 EPA04325.1 - 0.077 12.7 0.4 0.54 10.0 0.1 2.3 2 0 0 2 2 2 0 KOW motif CBS PF00571.23 EPA04326.1 - 3.3e-08 33.1 0.5 0.012 15.3 0.0 3.9 5 0 0 5 5 5 2 CBS domain DHFR_1 PF00186.14 EPA04326.1 - 0.0038 16.8 0.1 0.039 13.5 0.0 2.2 1 1 1 2 2 2 1 Dihydrofolate reductase ABC_tran PF00005.22 EPA04327.1 - 8.2e-12 45.5 0.0 8.7e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_25 PF13481.1 EPA04327.1 - 0.00011 21.6 0.0 0.00011 21.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EPA04327.1 - 0.00013 21.4 0.0 0.00017 21.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.1 EPA04327.1 - 0.00014 21.7 0.0 0.00016 21.5 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.1 EPA04327.1 - 0.00083 19.3 0.0 0.00083 19.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.14 EPA04327.1 - 0.0031 16.7 0.1 0.0038 16.4 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EPA04327.1 - 0.0033 17.7 0.1 0.0045 17.3 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EPA04327.1 - 0.0053 16.6 0.0 0.0072 16.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EPA04327.1 - 0.01 16.6 0.0 0.014 16.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EPA04327.1 - 0.011 15.6 0.0 0.012 15.6 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain ArgK PF03308.11 EPA04327.1 - 0.013 14.2 0.0 0.015 14.0 0.0 1.1 1 0 0 1 1 1 0 ArgK protein DUF258 PF03193.11 EPA04327.1 - 0.018 14.2 0.0 0.02 14.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_13 PF13166.1 EPA04327.1 - 0.025 13.0 0.0 0.025 13.0 0.0 1.0 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EPA04327.1 - 0.048 13.8 0.0 0.055 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EPA04327.1 - 0.051 13.5 0.0 0.055 13.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EPA04327.1 - 0.053 13.7 0.0 0.067 13.3 0.0 1.2 1 0 0 1 1 1 0 RNA helicase Adeno_IVa2 PF02456.10 EPA04327.1 - 0.056 12.0 0.0 0.059 12.0 0.0 1.0 1 0 0 1 1 1 0 Adenovirus IVa2 protein T2SE PF00437.15 EPA04327.1 - 0.06 12.2 0.0 0.065 12.1 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Arch_ATPase PF01637.13 EPA04327.1 - 0.11 12.2 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Archaeal ATPase cobW PF02492.14 EPA04327.1 - 0.11 11.9 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_10 PF12846.2 EPA04327.1 - 0.12 11.8 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_18 PF13238.1 EPA04327.1 - 0.12 12.6 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 EPA04327.1 - 0.12 11.9 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 NACHT domain MobB PF03205.9 EPA04327.1 - 0.14 11.8 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B FAM75 PF14650.1 EPA04328.1 - 0.011 15.2 3.5 0.011 15.1 2.4 1.0 1 0 0 1 1 1 0 FAM75 family DUF1640 PF07798.6 EPA04328.1 - 0.11 12.5 4.4 0.11 12.5 3.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF4473 PF14747.1 EPA04328.1 - 0.14 12.3 3.7 0.15 12.2 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) FCH PF00611.18 EPA04328.1 - 0.16 12.1 4.0 0.23 11.6 2.8 1.4 1 1 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain Cut12 PF11500.3 EPA04328.1 - 1.9 8.1 7.5 1.8 8.2 5.2 1.0 1 0 0 1 1 1 0 Spindle pole body formation-associated protein CSD PF00313.17 EPA04330.1 - 1.7e-21 75.7 3.8 2.1e-21 75.4 2.7 1.1 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.6 EPA04330.1 - 1e-06 28.1 0.9 1.1e-06 28.0 0.6 1.1 1 0 0 1 1 1 1 Ribonuclease B OB domain Gar1 PF04410.9 EPA04331.1 - 2.1e-05 24.0 0.0 2.2e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region DUF782 PF05614.6 EPA04331.1 - 0.082 13.0 0.0 0.087 13.0 0.0 1.1 1 0 0 1 1 1 0 Circovirus protein of unknown function (DUF782) eIF-1a PF01176.14 EPA04332.1 - 3.9e-22 77.4 1.9 5e-22 77.1 1.3 1.1 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myosin_N PF02736.14 EPA04332.1 - 0.13 11.9 1.3 6.5 6.5 0.0 2.5 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain CxxCxxCC PF03692.10 EPA04333.1 - 1.3e-10 41.5 0.3 2.9e-10 40.4 0.2 1.6 1 1 0 1 1 1 1 Putative zinc- or iron-chelating domain fn3 PF00041.16 EPA04334.1 - 0.00012 22.0 0.1 0.00036 20.6 0.0 1.7 2 0 0 2 2 2 1 Fibronectin type III domain DUF1411 PF07199.6 EPA04334.1 - 0.064 12.6 0.1 0.12 11.7 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1411) HTH_24 PF13412.1 EPA04335.1 - 4.9e-10 38.6 1.4 1.1e-09 37.5 1.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 EPA04335.1 - 2.8e-09 36.3 1.8 2.2e-08 33.5 0.8 2.5 2 1 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_12 PF08461.5 EPA04335.1 - 1.3e-07 31.2 1.7 1.3e-07 31.2 0.3 1.7 2 0 0 2 2 2 1 Ribonuclease R winged-helix domain HTH_11 PF08279.7 EPA04335.1 - 8.4e-07 28.5 0.6 3.5e-06 26.5 0.4 2.1 1 1 0 1 1 1 1 HTH domain Penicillinase_R PF03965.11 EPA04335.1 - 5.1e-05 23.3 0.3 0.00032 20.7 0.0 2.0 2 0 0 2 2 2 1 Penicillinase repressor HTH_Tnp_Tc3_2 PF01498.13 EPA04335.1 - 9.4e-05 22.3 1.1 0.00025 21.0 0.1 2.1 3 0 0 3 3 3 1 Transposase HTH_20 PF12840.2 EPA04335.1 - 0.00012 21.8 0.0 0.00017 21.2 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_DeoR PF08220.7 EPA04335.1 - 0.0025 17.3 0.1 0.0091 15.5 0.1 2.0 1 1 0 1 1 1 1 DeoR-like helix-turn-helix domain Myb_DNA-bind_4 PF13837.1 EPA04335.1 - 0.0099 15.9 0.2 0.022 14.8 0.0 1.6 2 0 0 2 2 1 1 Myb/SANT-like DNA-binding domain Arg_repressor PF01316.16 EPA04335.1 - 0.011 15.2 0.2 0.03 13.8 0.2 1.7 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain HTH_32 PF13565.1 EPA04335.1 - 0.013 16.2 0.0 0.029 15.1 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain RPA_C PF08784.6 EPA04335.1 - 0.014 15.7 0.0 0.029 14.7 0.0 1.6 1 0 0 1 1 1 0 Replication protein A C terminal FUR PF01475.14 EPA04335.1 - 0.02 14.7 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 Ferric uptake regulator family RNA_binding PF01877.12 EPA04335.1 - 0.034 14.1 1.2 0.067 13.2 0.2 1.8 2 0 0 2 2 2 0 RNA binding DUF3783 PF12646.2 EPA04335.1 - 0.059 13.1 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3783) HxlR PF01638.12 EPA04335.1 - 0.063 12.9 0.1 1.1 8.9 0.0 2.2 2 0 0 2 2 2 0 HxlR-like helix-turn-helix Sigma70_r4_2 PF08281.7 EPA04335.1 - 0.066 12.6 0.1 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 DUF2203 PF09969.4 EPA04335.1 - 0.15 12.3 0.5 0.4 10.9 0.1 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) HU-DNA_bdg PF14848.1 EPA04335.1 - 0.15 11.7 3.1 0.49 10.1 0.1 2.2 2 0 0 2 2 2 0 DNA-binding domain ADH_N PF08240.7 EPA04336.1 - 8.5e-35 118.8 0.9 1.3e-34 118.1 0.6 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EPA04336.1 - 3.1e-31 107.5 0.1 4.6e-31 107.0 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EPA04336.1 - 2.2e-11 44.7 0.0 3.9e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DapB_N PF01113.15 EPA04336.1 - 0.016 15.1 0.4 0.03 14.2 0.3 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus TrkA_N PF02254.13 EPA04336.1 - 0.024 14.6 0.3 0.061 13.3 0.1 1.8 2 0 0 2 2 2 0 TrkA-N domain Methyltransf_18 PF12847.2 EPA04336.1 - 0.076 13.5 0.0 0.19 12.2 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain TFIIB PF00382.14 EPA04337.1 - 5.1e-25 87.0 2.4 8.1e-13 47.9 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EPA04337.1 - 5.5e-09 35.2 1.2 5.5e-09 35.2 0.9 1.8 2 0 0 2 2 2 1 TFIIB zinc-binding Cys_knot PF00007.17 EPA04337.1 - 0.04 13.9 1.1 0.12 12.4 0.7 1.8 1 0 0 1 1 1 0 Cystine-knot domain zf-ribbon_3 PF13248.1 EPA04337.1 - 0.067 12.4 0.3 0.067 12.4 0.2 1.8 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS91 PF14319.1 EPA04337.1 - 0.068 12.6 2.1 0.97 8.9 0.1 2.4 2 0 0 2 2 2 0 Transposase zinc-binding domain DZR PF12773.2 EPA04337.1 - 0.079 12.7 2.7 0.18 11.6 0.2 2.3 2 0 0 2 2 2 0 Double zinc ribbon RPA_interact_C PF14768.1 EPA04337.1 - 0.11 12.9 2.6 3.9 7.9 0.1 2.7 2 2 0 2 2 2 0 Replication protein A interacting C-terminal DUF2318 PF10080.4 EPA04337.1 - 0.13 12.0 3.7 7.2 6.4 0.1 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) RRN7 PF11781.3 EPA04337.1 - 0.15 11.5 1.5 0.32 10.5 0.1 2.1 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 zinc-ribbons_6 PF07191.7 EPA04337.1 - 0.2 11.4 3.4 0.46 10.3 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbons ScpA_ScpB PF02616.9 EPA04338.1 - 4.4e-14 52.6 2.3 9.7e-07 28.6 0.3 2.1 1 1 0 2 2 2 2 ScpA/B protein SRP19 PF01922.12 EPA04339.1 - 1.1e-14 54.7 0.1 1.2e-14 54.5 0.1 1.0 1 0 0 1 1 1 1 SRP19 protein SRP54_N PF02881.14 EPA04339.1 - 0.1 12.7 2.5 2.1 8.5 0.0 2.1 2 0 0 2 2 2 0 SRP54-type protein, helical bundle domain PX PF00787.19 EPA04340.1 - 0.014 15.1 0.0 0.014 15.1 0.0 1.3 1 1 0 1 1 1 0 PX domain DUF387 PF04079.11 EPA04341.1 - 6e-36 123.2 0.7 7.2e-36 122.9 0.5 1.1 1 0 0 1 1 1 1 Putative transcriptional regulators (Ypuh-like) HHH_3 PF12836.2 EPA04341.1 - 0.042 13.8 0.0 0.11 12.4 0.0 1.8 1 1 0 1 1 1 0 Helix-hairpin-helix motif HTH_20 PF12840.2 EPA04341.1 - 0.048 13.4 0.1 0.2 11.4 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain PadR PF03551.9 EPA04341.1 - 0.055 13.2 0.5 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family TrmB PF01978.14 EPA04341.1 - 0.067 12.9 0.4 4 7.2 0.0 2.4 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB CorA PF01544.13 EPA04342.1 - 3.5e-72 242.8 6.8 3.5e-72 242.8 4.7 2.1 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein Herpes_UL92 PF03048.9 EPA04342.1 - 0.0048 16.5 0.4 0.018 14.6 0.2 2.0 1 1 0 1 1 1 1 UL92 family T2SF PF00482.18 EPA04342.1 - 0.013 15.4 0.0 0.013 15.4 0.0 3.2 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F Ribosomal_S8e PF01201.17 EPA04343.1 - 3e-25 88.9 6.0 3.2e-25 88.8 4.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e DUF690 PF05108.8 EPA04343.1 - 0.06 11.7 0.1 0.072 11.4 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF690) Response_reg PF00072.19 EPA04345.1 - 1.3e-16 60.6 0.2 1.9e-16 60.0 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain TPR_8 PF13181.1 EPA04345.1 - 0.0024 17.5 2.5 0.0071 16.0 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 EPA04345.1 - 0.0033 17.2 0.0 0.17 11.8 0.0 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 EPA04345.1 - 0.0082 16.0 0.5 0.59 10.1 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 EPA04345.1 - 0.026 14.1 0.0 0.077 12.6 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Apc3 PF12895.2 EPA04345.1 - 0.034 14.2 7.1 0.099 12.7 0.4 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3910 PF13049.1 EPA04345.1 - 0.14 12.2 1.1 0.73 9.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3910) SMC_N PF02463.14 EPA04345.1 - 0.22 10.6 1.3 0.37 9.9 0.4 2.0 1 1 1 2 2 2 0 RecF/RecN/SMC N terminal domain SCO1-SenC PF02630.9 EPA04345.1 - 0.32 10.6 4.8 4.5 6.8 0.2 2.4 2 1 0 2 2 2 0 SCO1/SenC CbiG_N PF11760.3 EPA04346.1 - 8.9e-33 111.8 0.2 1.4e-32 111.2 0.1 1.3 1 0 0 1 1 1 1 Cobalamin synthesis G N-terminal CbiG_C PF01890.11 EPA04346.1 - 6.1e-28 97.5 0.1 2e-27 95.8 0.0 1.8 2 0 0 2 2 2 1 Cobalamin synthesis G C-terminus CbiG_mid PF11761.3 EPA04346.1 - 4.6e-10 39.5 0.0 1.6e-09 37.8 0.0 1.9 2 0 0 2 2 2 1 Cobalamin biosynthesis central region CbiX PF01903.12 EPA04347.1 - 2.5e-16 59.7 0.0 2.7e-16 59.5 0.0 1.0 1 0 0 1 1 1 1 CbiX Trp_halogenase PF04820.9 EPA04348.1 - 1.5e-06 27.1 0.0 5.5e-06 25.2 0.0 1.7 1 1 0 1 1 1 1 Tryptophan halogenase DUF1687 PF07955.6 EPA04348.1 - 0.068 13.1 0.1 0.49 10.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1687) Transket_pyr PF02779.19 EPA04349.1 - 3.7e-11 42.8 0.0 3.7e-11 42.8 0.0 1.0 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Ribul_P_3_epim PF00834.14 EPA04350.1 - 1.9e-12 46.7 0.1 2.8e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family HATPase_c PF02518.21 EPA04351.1 - 2.7e-25 88.2 0.4 2.7e-25 88.2 0.3 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EPA04351.1 - 4.2e-11 42.6 0.1 8.2e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.1 EPA04351.1 - 1.1e-08 34.6 0.7 3.6e-08 33.0 0.5 1.9 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.1 EPA04351.1 - 0.017 14.7 4.2 0.088 12.4 2.6 2.2 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sigma70_r1_1 PF03979.9 EPA04351.1 - 0.019 14.9 0.3 0.07 13.0 0.2 2.0 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 HATPase_c_2 PF13581.1 EPA04351.1 - 0.025 14.3 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain RIG-I_C-RD PF11648.3 EPA04353.1 - 0.006 16.4 0.7 0.012 15.5 0.5 1.7 1 1 0 1 1 1 1 C-terminal domain of RIG-I Yippee-Mis18 PF03226.9 EPA04353.1 - 0.014 15.3 0.6 0.021 14.8 0.4 1.3 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DNA_processg_A PF02481.10 EPA04354.1 - 0.0011 17.8 0.2 0.0013 17.6 0.1 1.1 1 0 0 1 1 1 1 DNA recombination-mediator protein A HIT PF01230.18 EPA04355.1 - 4.9e-23 81.4 0.6 6.3e-23 81.1 0.4 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 EPA04355.1 - 4.8e-13 49.3 0.1 6.6e-13 48.9 0.1 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 EPA04355.1 - 0.00093 18.8 0.2 0.0012 18.4 0.1 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 GalP_UDP_tr_C PF02744.12 EPA04355.1 - 0.03 13.8 0.2 0.038 13.5 0.1 1.3 1 1 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain Cytochrome_C7 PF14522.1 EPA04356.1 - 0.0047 16.5 7.9 0.023 14.3 3.2 2.1 2 0 0 2 2 2 1 Cytochrome c7 zf-C4pol PF14260.1 EPA04356.1 - 0.0065 16.4 4.4 0.39 10.7 0.6 2.2 2 0 0 2 2 2 2 C4-type zinc-finger of DNA polymerase delta zf-CHY PF05495.7 EPA04356.1 - 0.02 15.0 9.4 0.054 13.6 3.3 2.3 2 0 0 2 2 2 0 CHY zinc finger C1_1 PF00130.17 EPA04356.1 - 0.069 12.8 1.0 0.069 12.8 0.7 2.6 1 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) GATA PF00320.22 EPA04356.1 - 0.07 12.4 0.8 0.07 12.4 0.6 2.8 2 1 0 2 2 2 0 GATA zinc finger FYVE PF01363.16 EPA04356.1 - 0.074 12.9 6.8 13 5.8 4.7 2.4 1 1 0 1 1 1 0 FYVE zinc finger DUF4428 PF14471.1 EPA04356.1 - 0.84 9.4 15.9 1.7 8.4 0.5 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4428) LIM PF00412.17 EPA04356.1 - 0.93 9.6 9.2 0.89 9.6 1.0 2.5 2 1 0 2 2 2 0 LIM domain Cytochrom_c3_2 PF14537.1 EPA04356.1 - 4.1 7.7 11.4 67 3.9 7.9 2.6 1 1 0 1 1 1 0 Cytochrome c3 HNH PF01844.18 EPA04356.1 - 4.6 7.1 9.5 24 4.9 0.2 3.9 3 1 0 4 4 4 0 HNH endonuclease DZR PF12773.2 EPA04356.1 - 6.4 6.6 12.2 1.7e+03 -1.1 8.5 2.9 1 1 0 1 1 1 0 Double zinc ribbon Endonuclease_7 PF02945.10 EPA04356.1 - 9.7 5.9 10.2 2.9e+02 1.2 7.1 2.8 1 1 0 1 1 1 0 Recombination endonuclease VII 3HCDH_N PF02737.13 EPA04357.1 - 3.1e-65 219.2 0.5 3.1e-65 219.2 0.3 1.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 EPA04357.1 - 7.9e-34 115.9 0.2 1.7e-26 92.4 0.1 2.9 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_Gly3P_dh_N PF01210.18 EPA04357.1 - 3e-07 30.2 0.2 5.1e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.10 EPA04357.1 - 6.1e-05 22.9 0.1 0.00012 21.9 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 EPA04357.1 - 0.0098 16.3 1.5 0.036 14.5 1.0 2.0 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.7 EPA04357.1 - 0.31 10.3 3.5 17 4.7 2.4 2.3 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain DUF643 PF04867.7 EPA04357.1 - 1.1 9.6 8.5 0.13 12.6 0.5 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF643) Microcin PF03526.8 EPA04358.1 - 0.089 12.4 0.1 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Colicin E1 (microcin) immunity protein DUF4415 PF14384.1 EPA04359.1 - 0.0097 16.0 0.1 0.0097 16.0 0.1 1.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4415) DUF217 PF02697.9 EPA04359.1 - 0.013 15.7 1.7 0.022 14.9 1.2 1.4 1 1 0 1 1 1 0 Uncharacterized ACR, COG1753 DUF2191 PF09957.4 EPA04359.1 - 0.02 14.6 0.1 0.031 14.0 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2191) RHH_1 PF01402.16 EPA04359.1 - 0.031 14.1 0.2 0.044 13.6 0.2 1.3 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family DnaJ PF00226.26 EPA04360.1 - 1.2e-14 53.7 0.8 2.6e-14 52.6 0.6 1.5 1 0 0 1 1 1 1 DnaJ domain Fer4_15 PF13459.1 EPA04360.1 - 1.5e-10 41.4 0.8 4.3e-10 40.0 0.6 1.8 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_13 PF13370.1 EPA04360.1 - 3.5e-10 40.0 1.3 9.7e-10 38.6 0.9 1.8 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_19 PF06902.6 EPA04360.1 - 0.00023 20.9 1.2 0.00056 19.6 0.8 1.6 1 1 0 1 1 1 1 Divergent 4Fe-4S mono-cluster Fer4_7 PF12838.2 EPA04360.1 - 0.023 15.0 0.4 1.7 9.0 0.1 2.6 2 0 0 2 2 2 0 4Fe-4S dicluster domain Phytochelatin PF05023.9 EPA04360.1 - 0.056 12.4 0.3 0.084 11.8 0.2 1.2 1 0 0 1 1 1 0 Phytochelatin synthase Fer4 PF00037.22 EPA04360.1 - 0.082 12.5 9.9 0.81 9.3 4.1 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain SRR PF07709.6 EPA04360.1 - 5.3 7.6 5.9 3.5 8.2 0.1 3.2 3 0 0 3 3 3 0 Seven Residue Repeat zf-H2C2_5 PF13909.1 EPA04361.1 - 0.00053 20.0 0.9 0.00075 19.5 0.6 1.3 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.21 EPA04361.1 - 0.074 13.4 3.1 0.11 12.8 2.1 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-BED PF02892.10 EPA04361.1 - 0.15 11.8 3.5 0.25 11.1 2.4 1.4 1 0 0 1 1 1 0 BED zinc finger Lysine_decarbox PF03641.9 EPA04362.1 - 0.00089 19.0 0.2 0.002 17.9 0.1 1.6 1 1 0 1 1 1 1 Possible lysine decarboxylase Nuc_deoxyrib_tr PF05014.10 EPA04362.1 - 0.024 14.5 0.1 0.027 14.3 0.0 1.2 1 1 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase DAGK_cat PF00781.19 EPA04362.1 - 0.058 12.8 0.2 0.058 12.8 0.1 1.3 1 1 0 1 1 1 0 Diacylglycerol kinase catalytic domain NAD_binding_7 PF13241.1 EPA04363.1 - 2.6e-20 72.5 1.5 4.4e-20 71.8 0.1 1.8 2 0 0 2 2 2 1 Putative NAD(P)-binding GARS_N PF02844.10 EPA04363.1 - 0.015 15.7 1.0 0.59 10.6 0.1 2.5 2 1 0 2 2 2 0 Phosphoribosylglycinamide synthetase, N domain ATP-synt_F PF01990.12 EPA04363.1 - 0.029 14.7 8.0 0.7 10.3 0.1 2.7 3 0 0 3 3 3 0 ATP synthase (F/14-kDa) subunit Lipocalin PF00061.18 EPA04363.1 - 0.052 13.5 4.8 0.21 11.5 0.8 2.4 1 1 1 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family Peripla_BP_4 PF13407.1 EPA04363.1 - 0.065 12.5 2.3 0.31 10.3 0.2 2.7 1 1 0 2 2 2 0 Periplasmic binding protein domain SKI PF01202.17 EPA04363.1 - 0.15 11.9 2.7 0.2 11.5 0.2 2.2 2 1 0 2 2 2 0 Shikimate kinase TrkA_N PF02254.13 EPA04363.1 - 0.15 12.0 4.3 0.14 12.1 0.9 2.4 2 1 0 2 2 2 0 TrkA-N domain Shikimate_DH PF01488.15 EPA04363.1 - 0.22 11.5 6.1 0.062 13.3 0.6 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Cas_Csa5 PF09702.5 EPA04363.1 - 0.62 10.1 5.6 0.25 11.4 1.4 1.9 1 1 0 2 2 2 0 CRISPR-associated protein (Cas_Csa5) Sigma70_r1_1 PF03979.9 EPA04363.1 - 3.6 7.5 9.4 5.9 6.8 0.0 3.1 4 0 0 4 4 4 0 Sigma-70 factor, region 1.1 GlutR_N PF05201.10 EPA04364.1 - 1.1e-41 141.9 0.7 2.2e-41 140.9 0.1 1.8 2 1 0 2 2 2 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.15 EPA04364.1 - 3.4e-23 82.2 0.0 6.3e-23 81.3 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GlutR_dimer PF00745.15 EPA04364.1 - 7.4e-09 35.4 1.6 1.7e-08 34.3 1.1 1.7 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain F420_oxidored PF03807.12 EPA04364.1 - 0.00024 21.4 0.0 0.0006 20.1 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 EPA04364.1 - 0.00029 20.0 0.0 0.0016 17.5 0.0 2.0 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 EPA04364.1 - 0.0012 18.8 0.0 0.0022 18.0 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding Malic_M PF03949.10 EPA04364.1 - 0.0041 16.7 0.0 0.0097 15.4 0.0 1.6 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain Saccharop_dh PF03435.13 EPA04364.1 - 0.029 13.3 0.0 0.053 12.4 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NAD_binding_7 PF13241.1 EPA04364.1 - 0.04 14.1 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_2 PF03446.10 EPA04364.1 - 0.055 13.2 0.1 0.28 10.9 0.0 2.1 2 1 1 3 3 3 0 NAD binding domain of 6-phosphogluconate dehydrogenase MAF_flag10 PF01973.13 EPA04364.1 - 0.062 12.8 0.0 0.27 10.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF115 LVIVD PF08309.6 EPA04364.1 - 0.092 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 LVIVD repeat AsnC_trans_reg PF01037.16 EPA04366.1 - 0.00021 20.9 0.1 2.7 7.7 0.0 4.7 3 2 1 4 4 4 1 AsnC family HTH_AsnC-type PF13404.1 EPA04366.1 - 0.0012 18.3 0.0 0.62 9.6 0.0 2.5 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain DUF2316 PF10078.4 EPA04366.1 - 0.087 12.8 0.0 21 5.1 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) PRA-CH PF01502.13 EPA04368.1 - 2e-35 120.2 0.1 2.5e-35 119.9 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase ThiF PF00899.16 EPA04369.1 - 1.8e-44 150.8 1.0 3.9e-44 149.7 0.7 1.5 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 EPA04369.1 - 9.4e-18 63.5 0.1 1.8e-17 62.6 0.1 1.5 1 0 0 1 1 1 1 MoeZ/MoeB domain ThiS PF02597.15 EPA04369.1 - 1.5e-05 25.2 0.0 4.5e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 ThiS family Shikimate_DH PF01488.15 EPA04369.1 - 0.0019 18.3 0.1 0.0059 16.7 0.0 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 EPA04369.1 - 0.012 14.8 0.0 0.024 13.8 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Vps53_N PF04100.7 EPA04370.1 - 0.053 12.3 0.0 0.065 12.0 0.0 1.1 1 0 0 1 1 1 0 Vps53-like, N-terminal His_biosynth PF00977.16 EPA04371.1 - 1.6e-58 197.6 0.6 1.8e-58 197.5 0.4 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Dus PF01207.12 EPA04371.1 - 1.7e-07 30.3 0.3 0.0013 17.6 0.0 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) DHO_dh PF01180.16 EPA04371.1 - 9.5e-05 21.4 0.1 0.035 13.0 0.0 2.2 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase TMP-TENI PF02581.12 EPA04371.1 - 0.00013 21.1 0.2 0.013 14.6 0.0 2.3 2 0 0 2 2 2 2 Thiamine monophosphate synthase/TENI ThiG PF05690.9 EPA04371.1 - 0.00042 19.4 0.4 0.27 10.2 0.0 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG PcrB PF01884.12 EPA04371.1 - 0.00059 19.1 1.8 0.00099 18.4 0.0 2.0 2 1 0 2 2 2 1 PcrB family NMO PF03060.10 EPA04371.1 - 0.001 18.2 0.6 0.033 13.3 0.1 2.1 2 0 0 2 2 2 1 Nitronate monooxygenase IMPDH PF00478.20 EPA04371.1 - 0.19 10.5 1.3 8.1 5.2 0.1 2.1 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain PALP PF00291.20 EPA04372.1 - 1.7e-66 224.5 1.1 1.9e-66 224.3 0.8 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACP_syn_III_C PF08541.5 EPA04372.1 - 0.021 14.8 0.4 0.1 12.6 0.0 2.3 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal THUMP PF02926.12 EPA04373.1 - 3.8e-06 26.8 0.1 5.5e-06 26.3 0.1 1.2 1 0 0 1 1 1 1 THUMP domain SRP54 PF00448.17 EPA04374.1 - 2e-30 105.7 0.0 3e-30 105.1 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 EPA04374.1 - 3.4e-30 104.3 1.0 8.1e-30 103.1 0.7 1.6 1 0 0 1 1 1 1 Signal peptide binding domain Chlor_dismutase PF06778.7 EPA04375.1 - 1.3e-48 165.3 0.3 1.4e-48 165.1 0.2 1.0 1 0 0 1 1 1 1 Chlorite dismutase Aldo_ket_red PF00248.16 EPA04376.1 - 4.4e-56 189.7 0.1 5e-56 189.6 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1802 PF08819.6 EPA04378.1 - 1.7e-45 154.8 0.1 1.9e-45 154.6 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1802) DUF1743 PF08489.6 EPA04379.1 - 1.9e-34 117.9 0.0 4.3e-34 116.7 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1743) Exo5 PF09810.4 EPA04379.1 - 0.03 13.5 0.0 0.044 13.0 0.0 1.1 1 0 0 1 1 1 0 Exonuclease V - a 5' deoxyribonuclease Asp_Glu_race PF01177.17 EPA04380.1 - 1.8e-20 73.7 0.0 2.2e-20 73.5 0.0 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase ADIP PF11559.3 EPA04381.1 - 0.013 15.3 0.1 0.014 15.2 0.1 1.0 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4248 PF14053.1 EPA04381.1 - 0.059 12.9 0.1 0.18 11.3 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4248) Syntaxin_2 PF14523.1 EPA04381.1 - 0.088 12.8 0.1 0.1 12.6 0.1 1.2 1 0 0 1 1 1 0 Syntaxin-like protein Spc24 PF08286.6 EPA04381.1 - 0.098 12.3 0.1 0.11 12.2 0.1 1.1 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 SMC_N PF02463.14 EPA04382.1 - 0.0099 15.1 0.0 0.011 14.9 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain FR47 PF08445.5 EPA04382.1 - 0.054 13.2 0.0 0.099 12.4 0.0 1.4 2 0 0 2 2 2 0 FR47-like protein AAA_21 PF13304.1 EPA04382.1 - 0.074 13.0 0.0 0.092 12.6 0.0 1.1 1 0 0 1 1 1 0 AAA domain NHL PF01436.16 EPA04383.1 - 6.2e-07 29.0 0.0 1e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 NHL repeat SGL PF08450.7 EPA04383.1 - 0.00019 20.9 0.0 0.00019 20.8 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region SBBP PF06739.6 EPA04383.1 - 0.002 17.8 2.1 0.004 16.9 1.4 1.7 1 1 0 1 1 1 1 Beta-propeller repeat DHQS PF01959.11 EPA04384.1 - 4.8e-110 367.5 1.2 5.3e-110 367.4 0.9 1.0 1 0 0 1 1 1 1 3-dehydroquinate synthase (EC 4.6.1.3) DeoC PF01791.4 EPA04385.1 - 5e-48 163.4 0.0 6e-48 163.1 0.0 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase PEP_mutase PF13714.1 EPA04385.1 - 0.098 11.8 0.1 0.29 10.3 0.0 1.8 1 1 0 1 1 1 0 Phosphoenolpyruvate phosphomutase DHquinase_I PF01487.10 EPA04386.1 - 1.9e-19 70.2 0.1 2e-19 70.1 0.1 1.0 1 0 0 1 1 1 1 Type I 3-dehydroquinase CBS PF00571.23 EPA04388.1 - 1.8e-23 82.0 0.7 4e-11 42.5 0.2 2.2 2 0 0 2 2 2 2 CBS domain IMPDH PF00478.20 EPA04388.1 - 3.1e-09 36.1 0.0 3.4e-09 36.0 0.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain RVT_3 PF13456.1 EPA04388.1 - 0.074 12.8 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase-like FAD_binding_4 PF01565.18 EPA04388.1 - 0.092 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain CAP160 PF07918.6 EPA04388.1 - 0.15 11.6 1.4 0.24 11.0 0.2 1.9 2 0 0 2 2 2 0 CAP160 repeat Aldo_ket_red PF00248.16 EPA04389.1 - 6.8e-53 179.3 0.1 7.6e-53 179.1 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family ERM PF00769.14 EPA04391.1 - 0.016 14.7 3.4 0.02 14.4 2.3 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF4330 PF14221.1 EPA04391.1 - 0.12 12.2 2.0 9.7 6.0 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4330) Sedlin_N PF04628.8 EPA04392.1 - 0.7 9.7 3.7 1.9 8.3 0.4 2.8 1 1 1 2 2 2 0 Sedlin, N-terminal conserved region Aminotran_1_2 PF00155.16 EPA04393.1 - 4e-41 141.1 0.0 5.2e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EPA04393.1 - 0.05 12.7 0.0 0.094 11.8 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase Methyltransf_21 PF05050.7 EPA04394.1 - 2e-16 60.4 0.1 2.9e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain EIF_2_alpha PF07541.7 EPA04395.1 - 7.4e-24 83.6 2.6 8e-24 83.5 0.4 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 EPA04395.1 - 9.1e-13 48.1 0.2 6.5e-12 45.3 0.1 2.4 2 0 0 2 2 2 1 S1 RNA binding domain EXOSC1 PF10447.4 EPA04395.1 - 0.038 13.9 0.6 0.29 11.1 0.1 2.5 2 1 0 2 2 2 0 Exosome component EXOSC1/CSL4 MBT PF02820.13 EPA04395.1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 mbt repeat DUF3782 PF12644.2 EPA04395.1 - 0.19 11.5 3.9 9.3 6.1 4.1 2.4 2 2 0 2 2 2 0 Protein of unknown function (DUF3782) CbiA PF01656.18 EPA04396.1 - 8.2e-25 87.3 0.0 1.2e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.1 EPA04396.1 - 1.3e-11 44.5 0.6 2.1e-05 24.2 0.0 2.2 1 1 1 2 2 2 2 AAA domain YhjQ PF06564.7 EPA04396.1 - 0.0093 15.3 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 YhjQ protein SRP54 PF00448.17 EPA04396.1 - 0.013 14.9 0.3 0.19 11.1 0.0 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain CTP_synth_N PF06418.9 EPA04396.1 - 0.015 14.3 0.7 0.036 13.1 0.0 1.9 2 1 1 3 3 3 0 CTP synthase N-terminus AAA_18 PF13238.1 EPA04396.1 - 0.033 14.4 0.1 0.089 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 EPA04396.1 - 0.048 13.9 3.4 0.17 12.1 2.3 1.8 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 EPA04396.1 - 0.055 12.8 0.3 0.15 11.4 0.1 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein CbiC PF02570.10 EPA04398.1 - 8.8e-74 247.2 1.0 1e-73 247.0 0.7 1.0 1 0 0 1 1 1 1 Precorrin-8X methylmutase CbiX PF01903.12 EPA04399.1 - 8.9e-16 57.9 0.0 1.2e-15 57.5 0.0 1.1 1 0 0 1 1 1 1 CbiX CbiK PF06180.6 EPA04399.1 - 1.2e-05 24.5 0.2 1.4e-05 24.3 0.1 1.0 1 0 0 1 1 1 1 Cobalt chelatase (CbiK) GATase_3 PF07685.9 EPA04400.1 - 8.4e-26 90.4 0.3 9.4e-26 90.2 0.2 1.0 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DUF1836 PF08876.6 EPA04400.1 - 0.011 15.4 0.1 0.018 14.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1836) Sec23_BS PF08033.7 EPA04400.1 - 0.057 13.9 0.0 0.079 13.4 0.0 1.3 1 0 0 1 1 1 0 Sec23/Sec24 beta-sandwich domain Beta_helix PF13229.1 EPA04400.1 - 0.088 12.5 0.1 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 Right handed beta helix region Endosulfine PF04667.12 EPA04400.1 - 0.28 11.1 4.1 1.9 8.5 0.1 2.9 2 1 0 2 2 2 0 cAMP-regulated phosphoprotein/endosulfine conserved region Nop10p PF04135.7 EPA04401.1 - 2.2e-23 81.7 3.0 2.3e-23 81.6 2.1 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family RecR PF02132.10 EPA04401.1 - 0.0018 17.6 0.9 0.0021 17.4 0.7 1.2 1 0 0 1 1 1 1 RecR protein DUF1272 PF06906.6 EPA04401.1 - 0.041 13.7 1.0 0.046 13.5 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) PolC_DP2 PF03833.8 EPA04401.1 - 0.091 10.4 0.3 0.081 10.5 0.2 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-C3HC4_3 PF13920.1 EPA04401.1 - 0.14 11.8 3.0 0.17 11.5 2.1 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Tet_res_leader PF08050.7 EPA04401.1 - 0.21 11.2 0.4 0.21 11.2 0.3 1.6 2 0 0 2 2 2 0 Tetracycline resistance leader peptide DUF329 PF03884.9 EPA04401.1 - 1.7 8.2 4.6 0.97 9.0 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF329) CobA_CobO_BtuR PF02572.10 EPA04402.1 - 2.4e-60 203.0 0.2 2.7e-60 202.9 0.1 1.0 1 0 0 1 1 1 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP AAA_14 PF13173.1 EPA04402.1 - 0.0007 19.5 0.6 0.0011 18.8 0.4 1.6 1 1 0 1 1 1 1 AAA domain Response_reg PF00072.19 EPA04402.1 - 0.028 14.4 0.1 0.046 13.7 0.1 1.4 1 0 0 1 1 1 0 Response regulator receiver domain IstB_IS21 PF01695.12 EPA04402.1 - 0.21 10.9 1.9 1 8.7 0.1 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.1 EPA04402.1 - 0.51 9.7 3.7 4.3 6.6 2.3 2.4 1 1 1 2 2 2 0 AAA domain DUF202 PF02656.10 EPA04403.1 - 0.048 13.8 0.2 0.39 10.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF202) DUF3040 PF11239.3 EPA04403.1 - 0.088 12.8 0.7 0.45 10.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) DUF872 PF05915.7 EPA04403.1 - 0.11 12.3 0.4 0.23 11.3 0.0 1.7 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) SdpI PF13630.1 EPA04403.1 - 0.12 12.1 4.6 0.41 10.3 0.8 2.3 2 0 0 2 2 2 0 SdpI/YhfL protein family Shisa PF13908.1 EPA04403.1 - 0.32 11.1 0.1 0.32 11.1 0.0 1.4 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator YtpI PF14007.1 EPA04403.1 - 0.5 10.3 5.9 0.084 12.8 1.0 1.9 2 0 0 2 2 2 0 YtpI-like protein DUF2839 PF10999.3 EPA04403.1 - 4 7.5 6.9 5 7.2 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) tRNA_anti-codon PF01336.20 EPA04404.1 - 3.2e-06 26.9 0.2 4.1e-06 26.5 0.1 1.2 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain HupF_HypC PF01455.13 EPA04404.1 - 0.051 13.5 0.9 2.3 8.2 0.5 2.1 1 1 1 2 2 2 0 HupF/HypC family GSDH PF07995.6 EPA04405.1 - 2.4e-19 69.5 0.0 3e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase HATPase_c PF02518.21 EPA04406.1 - 1.8e-26 92.0 0.1 3.9e-26 90.9 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.19 EPA04406.1 - 3.9e-13 49.1 0.0 7.7e-12 44.9 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.1 EPA04406.1 - 1.4e-12 47.9 0.0 4.1e-12 46.3 0.0 1.9 1 0 0 1 1 1 1 PAS domain HisKA PF00512.20 EPA04406.1 - 4.5e-09 36.1 0.1 9.7e-09 35.1 0.1 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.5 EPA04406.1 - 4.3e-07 29.9 0.0 6.2e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.1 EPA04406.1 - 0.00016 21.5 0.0 0.0048 16.8 0.0 2.5 2 0 0 2 2 2 1 PAS domain HATPase_c_5 PF14501.1 EPA04406.1 - 0.00023 20.7 0.0 0.00064 19.3 0.0 1.8 1 0 0 1 1 1 1 GHKL domain PAS_8 PF13188.1 EPA04406.1 - 0.00027 20.6 0.0 0.001 18.8 0.0 2.0 2 0 0 2 2 2 1 PAS domain PAS_3 PF08447.6 EPA04406.1 - 0.0037 17.3 0.0 0.0078 16.2 0.0 1.6 1 0 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.1 EPA04406.1 - 0.0076 15.8 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IFT46_B_C PF12317.3 EPA04406.1 - 0.059 12.7 1.4 0.09 12.1 1.0 1.3 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal Rho_GDI PF02115.12 EPA04406.1 - 0.068 12.5 0.1 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 RHO protein GDP dissociation inhibitor SnoaL_3 PF13474.1 EPA04408.1 - 4.3e-08 33.2 0.0 5.4e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain CaMKII_AD PF08332.5 EPA04408.1 - 5.2e-06 26.3 0.0 1.1e-05 25.3 0.0 1.5 1 1 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II Association DUF4440 PF14534.1 EPA04408.1 - 0.0011 19.1 0.0 0.0015 18.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) ALS_ss_C PF10369.4 EPA04409.1 - 2.3e-24 84.8 0.4 2.2e-22 78.5 0.0 2.2 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT_5 PF13710.1 EPA04409.1 - 4.4e-17 61.6 0.0 1.1e-16 60.3 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT PF01842.20 EPA04409.1 - 3.3e-13 48.7 0.0 6.1e-13 47.9 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.1 EPA04409.1 - 0.00069 19.8 0.1 0.0016 18.7 0.1 1.7 1 0 0 1 1 1 1 ACT domain Acylphosphatase PF00708.13 EPA04409.1 - 0.057 13.5 0.2 0.23 11.5 0.1 1.9 2 0 0 2 2 2 0 Acylphosphatase DUF2344 PF10105.4 EPA04409.1 - 0.093 12.2 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) TPP_enzyme_N PF02776.13 EPA04410.1 - 2.4e-61 206.2 0.4 3.1e-59 199.3 0.1 2.6 2 1 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 EPA04410.1 - 1.6e-47 160.8 0.3 3.1e-46 156.7 0.0 2.8 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 EPA04410.1 - 3.4e-45 153.1 0.1 8.5e-45 151.8 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain HMGL-like PF00682.14 EPA04411.1 - 2.9e-77 259.5 0.4 3.3e-77 259.3 0.3 1.0 1 0 0 1 1 1 1 HMGL-like Glyco_hydro_97 PF10566.4 EPA04411.1 - 0.00015 20.9 0.0 0.00023 20.3 0.0 1.3 1 0 0 1 1 1 1 Glycoside hydrolase 97 AP_endonuc_2 PF01261.19 EPA04411.1 - 0.017 14.4 0.1 3.4 6.8 0.0 2.2 1 1 1 2 2 2 0 Xylose isomerase-like TIM barrel YbaJ PF10757.4 EPA04411.1 - 0.099 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Biofilm formation regulator YbaJ DUF2517 PF10725.4 EPA04412.1 - 0.096 12.3 0.3 0.19 11.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2517) DegV PF02645.11 EPA04413.1 - 0.012 14.7 0.5 0.018 14.1 0.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein, DegV family COG1307 Rabaptin PF03528.10 EPA04413.1 - 0.043 13.7 0.6 0.14 12.0 0.4 1.9 1 1 0 1 1 1 0 Rabaptin RIH_assoc PF08454.6 EPA04413.1 - 0.048 13.2 2.7 0.066 12.8 1.6 1.5 1 1 0 1 1 1 0 RyR and IP3R Homology associated Tweety PF04906.8 EPA04413.1 - 0.069 11.5 0.8 0.079 11.3 0.6 1.2 1 0 0 1 1 1 0 Tweety GAD PF02938.9 EPA04413.1 - 0.1 12.7 0.6 0.65 10.1 0.1 2.0 1 1 1 2 2 2 0 GAD domain Fib_alpha PF08702.5 EPA04413.1 - 0.43 10.6 4.4 1.1 9.3 0.1 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Sec8_exocyst PF04048.9 EPA04413.1 - 1.7 8.2 7.8 1.9 8.1 1.1 2.1 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain TFIIB PF00382.14 EPA04417.1 - 1.4e-33 114.4 6.4 3.5e-18 65.1 0.2 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EPA04417.1 - 6e-13 47.8 1.4 1.1e-12 47.0 1.0 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.18 EPA04417.1 - 3e-05 23.5 0.5 0.00041 19.9 0.1 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Lar_restr_allev PF14354.1 EPA04417.1 - 0.012 15.8 0.5 0.035 14.3 0.4 1.7 1 0 0 1 1 1 0 Restriction alleviation protein Lar Peptidase_M13_N PF05649.8 EPA04417.1 - 0.014 14.4 1.0 0.21 10.5 0.4 2.4 2 1 1 3 3 3 0 Peptidase family M13 RRN7 PF11781.3 EPA04417.1 - 0.021 14.3 0.4 0.047 13.1 0.2 1.7 1 0 0 1 1 1 0 RNA polymerase I-specific transcription initiation factor Rrn7 OrfB_Zn_ribbon PF07282.6 EPA04417.1 - 0.035 13.7 0.9 0.081 12.5 0.6 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.1 EPA04417.1 - 0.053 12.7 5.0 0.21 10.8 3.7 1.8 1 1 1 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.2 EPA04417.1 - 0.054 13.3 0.3 0.12 12.1 0.2 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Ribosomal_S27e PF01667.12 EPA04417.1 - 0.058 12.9 0.4 0.13 11.7 0.3 1.5 1 0 0 1 1 1 0 Ribosomal protein S27 Translin PF01997.11 EPA04417.1 - 0.059 12.9 0.0 0.085 12.4 0.0 1.2 1 0 0 1 1 1 0 Translin family zf-C4_Topoisom PF01396.14 EPA04417.1 - 0.89 9.1 3.8 0.63 9.5 1.4 1.8 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf-NADH-PPase PF09297.6 EPA04417.1 - 5.5 6.5 5.9 3.4 7.2 0.4 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Antitoxin-MazE PF04014.13 EPA04418.1 - 0.00013 21.6 0.1 0.00024 20.7 0.1 1.5 1 0 0 1 1 1 1 Antidote-toxin recognition MazE LLC1 PF14945.1 EPA04418.1 - 0.043 14.1 0.1 0.06 13.6 0.0 1.3 1 0 0 1 1 1 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Tantalus PF15386.1 EPA04418.1 - 0.45 10.3 3.6 8.8 6.1 0.0 2.7 2 1 1 3 3 3 0 Drosophila Tantalus-like PMSR PF01625.16 EPA04419.1 - 6.3e-66 221.0 0.9 6.8e-66 220.9 0.6 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Pox_I3 PF04661.7 EPA04419.1 - 0.053 12.3 0.0 0.066 12.0 0.0 1.1 1 0 0 1 1 1 0 Poxvirus I3 ssDNA-binding protein Abhydrolase_6 PF12697.2 EPA04420.1 - 9.7e-40 136.8 0.0 1.1e-39 136.6 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EPA04420.1 - 3.5e-24 85.6 0.0 2.7e-23 82.7 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EPA04420.1 - 1.7e-16 60.2 0.0 5.5e-16 58.6 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EPA04420.1 - 9.4e-06 25.2 0.1 0.29 10.5 0.0 3.1 2 1 2 4 4 4 2 Phospholipase/Carboxylesterase Ndr PF03096.9 EPA04420.1 - 1.1e-05 24.1 0.0 1.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Ndr family Ser_hydrolase PF06821.8 EPA04420.1 - 0.00012 21.7 0.0 0.034 13.7 0.0 2.8 1 1 0 1 1 1 1 Serine hydrolase Hydrolase_4 PF12146.3 EPA04420.1 - 0.00014 21.6 0.0 0.00029 20.6 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase FSH1 PF03959.8 EPA04420.1 - 0.1 12.0 0.0 0.18 11.2 0.0 1.6 1 1 0 1 1 1 0 Serine hydrolase (FSH1) UPF0227 PF05728.7 EPA04420.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) PhaC_N PF07167.8 EPA04421.1 - 2.2e-12 46.7 0.1 4.9e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus Abhydrolase_1 PF00561.15 EPA04421.1 - 5.7e-10 39.1 0.0 8.7e-10 38.5 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF3141 PF11339.3 EPA04421.1 - 2e-06 26.4 0.1 2.9e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3141) Abhydrolase_6 PF12697.2 EPA04421.1 - 3.7e-06 26.9 0.0 6.3e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EPA04421.1 - 2e-05 24.3 0.0 0.00011 22.0 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.13 EPA04421.1 - 0.0013 18.0 0.0 0.009 15.3 0.0 2.0 2 0 0 2 2 2 1 Dienelactone hydrolase family BAAT_C PF08840.6 EPA04421.1 - 0.0041 16.8 0.0 0.0084 15.8 0.0 1.5 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal PHB_depo_C PF06850.6 EPA04421.1 - 0.0073 15.5 0.0 0.052 12.7 0.0 2.2 1 1 1 2 2 2 1 PHB de-polymerase C-terminus Pribosyltran PF00156.22 EPA04422.1 - 1.1e-08 34.8 0.1 5.8e-05 22.8 0.0 2.5 1 1 2 3 3 3 2 Phosphoribosyl transferase domain FF PF01846.14 EPA04422.1 - 0.013 15.4 0.3 3.2 7.7 0.1 2.4 2 0 0 2 2 2 0 FF domain DUF956 PF06115.6 EPA04422.1 - 0.041 13.4 0.2 2.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF956) PHA_synth_III_E PF09712.5 EPA04423.1 - 1.5e-09 37.6 0.0 1.8e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) DUF4200 PF13863.1 EPA04423.1 - 0.029 14.3 8.5 0.072 13.0 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Phasin PF05597.6 EPA04423.1 - 0.049 13.3 1.1 0.13 11.9 0.8 1.9 1 1 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Seryl_tRNA_N PF02403.17 EPA04423.1 - 0.079 12.9 6.9 0.041 13.8 1.7 2.2 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain KxDL PF10241.4 EPA04423.1 - 0.11 12.4 2.3 2.4 8.0 0.0 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein Retrotrans_gag PF03732.12 EPA04423.1 - 0.22 11.6 2.4 6.1 6.9 0.3 3.2 2 1 1 3 3 3 0 Retrotransposon gag protein IFP_35_N PF07334.8 EPA04423.1 - 0.26 11.2 12.4 0.25 11.3 3.8 2.8 3 1 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Uds1 PF15456.1 EPA04423.1 - 0.63 10.0 4.7 0.77 9.7 1.7 2.1 2 0 0 2 2 2 0 Up-regulated During Septation Usp PF00582.21 EPA04424.1 - 1.4e-27 96.5 0.0 1.7e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family CutA1 PF03091.10 EPA04425.1 - 1.3e-29 101.8 4.6 1.4e-29 101.7 3.2 1.0 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein Glycos_transf_2 PF00535.21 EPA04425.1 - 0.018 14.7 0.1 0.023 14.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 2 DUF240 PF03086.9 EPA04425.1 - 0.052 13.1 0.3 0.074 12.6 0.2 1.2 1 0 0 1 1 1 0 MG032/MG096/MG288 family 2 RAP-1 PF03085.10 EPA04425.1 - 0.1 11.9 1.3 0.13 11.6 0.9 1.2 1 1 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) eRF1_3 PF03465.10 EPA04426.1 - 4.2e-11 43.1 0.8 3e-10 40.3 0.2 2.3 2 1 0 2 2 2 1 eRF1 domain 3 eRF1_2 PF03464.10 EPA04426.1 - 5.3e-09 36.4 1.0 1.3e-08 35.2 0.1 2.0 2 1 1 3 3 3 1 eRF1 domain 2 Ribosomal_L7Ae PF01248.21 EPA04426.1 - 0.0011 18.4 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF3512 PF12024.3 EPA04426.1 - 0.048 12.9 0.2 0.068 12.4 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3512) TrmB PF01978.14 EPA04428.1 - 0.032 13.9 0.1 0.059 13.0 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Cytokin_check_N PF10407.4 EPA04428.1 - 0.07 12.7 2.1 0.78 9.3 0.7 2.7 2 1 1 3 3 3 0 Cdc14 phosphatase binding protein N-terminus SUR7 PF06687.7 EPA04429.1 - 0.33 10.4 7.2 0.45 10.0 5.0 1.2 1 0 0 1 1 1 0 SUR7/PalI family Mga PF05043.8 EPA04430.1 - 0.033 14.4 0.6 0.15 12.3 0.1 2.3 2 0 0 2 2 2 0 Mga helix-turn-helix domain RepB-RCR_reg PF10723.4 EPA04432.1 - 0.033 13.9 0.8 0.035 13.8 0.6 1.1 1 0 0 1 1 1 0 Replication regulatory protein RepB MatP PF06303.7 EPA04432.1 - 0.14 12.0 0.4 0.15 11.9 0.3 1.0 1 0 0 1 1 1 0 Organiser of macrodomain of Terminus of chromosome DUF4066 PF13278.1 EPA04433.1 - 0.13 11.5 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 Putative amidotransferase DUF4455 PF14643.1 EPA04434.1 - 0.0086 14.7 0.3 0.011 14.3 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4455) Toxin_R_bind_C PF07951.7 EPA04434.1 - 0.022 14.4 0.4 0.024 14.3 0.3 1.0 1 0 0 1 1 1 0 Clostridium neurotoxin, C-terminal receptor binding Terminase_6 PF03237.10 EPA04435.1 - 2.9e-07 29.5 0.1 1e-06 27.7 0.1 1.8 1 1 0 1 1 1 1 Terminase-like family DUF1793 PF08760.6 EPA04435.1 - 0.064 13.1 0.1 1.3 8.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1793) Terminase_6 PF03237.10 EPA04436.1 - 0.014 14.1 0.0 0.023 13.4 0.0 1.4 1 1 0 1 1 1 0 Terminase-like family Phage_integrase PF00589.17 EPA04437.1 - 5.9e-10 39.0 1.6 6.9e-10 38.8 0.2 1.8 2 0 0 2 2 2 1 Phage integrase family F-112 PF09645.5 EPA04437.1 - 0.12 12.2 1.5 0.31 10.9 0.0 2.4 2 1 0 2 2 2 0 F-112 protein DUF2680 PF10925.3 EPA04437.1 - 0.52 10.2 3.6 5.5 6.9 1.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) DUF1922 PF09082.5 EPA04438.1 - 0.028 14.4 1.3 0.24 11.4 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1922) FerI PF08151.7 EPA04438.1 - 0.12 12.4 1.1 9 6.4 0.1 2.0 1 1 1 2 2 2 0 FerI (NUC094) domain DUF4337 PF14235.1 EPA04438.1 - 0.62 9.8 2.2 0.62 9.8 1.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) CRA_rpt PF07046.6 EPA04438.1 - 0.76 9.8 6.7 3.8 7.5 2.5 3.1 1 1 1 2 2 2 0 Cytoplasmic repetitive antigen (CRA) like repeat Spc24 PF08286.6 EPA04438.1 - 0.78 9.4 5.3 0.8 9.4 3.7 1.1 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF972 PF06156.8 EPA04438.1 - 1.1 9.6 3.8 1.5 9.2 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Cir_N PF10197.4 EPA04438.1 - 8.4 6.5 9.9 13 5.8 1.8 2.3 2 0 0 2 2 2 0 N-terminal domain of CBF1 interacting co-repressor CIR DUF3006 PF11213.3 EPA04439.1 - 0.29 10.9 6.3 8.8 6.1 1.2 3.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3006) GAS PF13851.1 EPA04439.1 - 3.6 6.7 27.9 29 3.7 19.4 2.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF3740 PF12548.3 EPA04439.1 - 6.4 7.0 12.5 4.8 7.4 2.9 2.4 1 1 2 3 3 3 0 Sulfatase protein Transketolase_C PF02780.15 EPA04440.1 - 1.7e-29 102.2 0.0 2.7e-29 101.6 0.0 1.3 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.19 EPA04440.1 - 5.2e-14 52.1 0.0 8.2e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DUF4493 PF14900.1 EPA04440.1 - 0.13 11.8 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4493) Transaldolase PF00923.14 EPA04441.1 - 1.9e-09 37.0 0.0 2.1e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Transaldolase PCMT PF01135.14 EPA04442.1 - 7.8e-57 192.1 0.0 9.3e-57 191.9 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 EPA04442.1 - 4e-11 42.7 0.0 7.1e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA04442.1 - 1.1e-09 38.8 0.0 2.2e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 EPA04442.1 - 1.2e-08 34.3 0.0 1.7e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.9 EPA04442.1 - 8.1e-06 25.3 0.0 1.7e-05 24.2 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.12 EPA04442.1 - 1.7e-05 23.9 0.0 2.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 EPA04442.1 - 2.1e-05 24.5 0.0 3.6e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.5 EPA04442.1 - 5.8e-05 22.7 0.0 9.9e-05 21.9 0.0 1.4 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit GidB PF02527.10 EPA04442.1 - 6.5e-05 22.1 0.1 0.0002 20.5 0.0 1.7 2 0 0 2 2 2 1 rRNA small subunit methyltransferase G Methyltransf_11 PF08241.7 EPA04442.1 - 0.00074 19.9 0.0 0.0012 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EPA04442.1 - 0.0021 17.1 0.0 0.0031 16.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 EPA04442.1 - 0.0024 17.0 0.0 0.0035 16.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EPA04442.1 - 0.0027 18.0 0.0 0.006 16.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Fibrillarin PF01269.12 EPA04442.1 - 0.013 14.3 0.0 0.02 13.8 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin Methyltransf_23 PF13489.1 EPA04442.1 - 0.017 14.8 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.7 EPA04442.1 - 0.03 13.8 0.0 0.045 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Met_10 PF02475.11 EPA04442.1 - 0.043 13.3 0.0 0.065 12.8 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_32 PF13679.1 EPA04442.1 - 0.044 13.4 0.0 0.064 12.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.12 EPA04442.1 - 0.045 12.7 0.0 0.073 12.1 0.0 1.4 1 1 0 1 1 1 0 O-methyltransferase Methyltransf_24 PF13578.1 EPA04442.1 - 0.049 14.4 0.0 0.079 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DOT1 PF08123.8 EPA04442.1 - 0.051 12.8 0.0 0.092 12.0 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 FlpD PF02662.11 EPA04443.1 - 0.014 15.1 0.2 0.014 15.0 0.1 1.1 1 0 0 1 1 1 0 Methyl-viologen-reducing hydrogenase, delta subunit MRP-S26 PF14943.1 EPA04443.1 - 0.07 12.6 1.1 0.073 12.6 0.8 1.0 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 DUF2205 PF10224.4 EPA04445.1 - 0.13 11.8 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) RDD PF06271.7 EPA04447.1 - 1.5e-20 73.4 4.1 1.8e-20 73.2 2.8 1.1 1 0 0 1 1 1 1 RDD family Methyltransf_11 PF08241.7 EPA04448.1 - 6.1e-11 42.6 0.0 9.9e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA04448.1 - 5.6e-06 26.0 0.0 8.8e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA04448.1 - 0.00073 19.9 0.0 0.0013 19.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA04448.1 - 0.0021 17.8 0.0 0.0032 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 EPA04448.1 - 0.0025 17.5 0.0 0.0069 16.0 0.0 1.9 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.9 EPA04448.1 - 0.13 11.6 0.0 1 8.7 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase small domain CofC PF01983.11 EPA04451.1 - 5.1e-21 74.6 4.1 6.6e-21 74.2 2.9 1.0 1 0 0 1 1 1 1 Guanylyl transferase CofC like NTP_transf_3 PF12804.2 EPA04451.1 - 4.5e-06 26.8 0.0 5.5e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4504 PF14953.1 EPA04451.1 - 0.036 13.3 0.0 0.062 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4504) DUF1270 PF06900.6 EPA04452.1 - 0.42 10.7 0.2 0.42 10.7 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1270) BofA PF07441.6 EPA04452.1 - 1.9 8.5 9.2 0.087 12.8 0.6 2.3 2 1 0 2 2 2 0 SigmaK-factor processing regulatory protein BofA zinc_ribbon_6 PF14599.1 EPA04453.1 - 0.00096 18.9 0.9 0.0011 18.7 0.7 1.1 1 0 0 1 1 1 1 Zinc-ribbon zf-CHY PF05495.7 EPA04453.1 - 0.004 17.2 2.1 0.004 17.2 1.4 1.0 1 0 0 1 1 1 1 CHY zinc finger HypA PF01155.14 EPA04453.1 - 0.0068 16.0 1.4 0.007 16.0 0.9 1.0 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family C1_1 PF00130.17 EPA04453.1 - 0.0073 16.0 1.4 0.0075 15.9 1.0 1.1 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Cytochrom_CIII PF02085.11 EPA04453.1 - 0.013 15.5 1.3 0.013 15.5 0.9 1.0 1 0 0 1 1 1 0 Class III cytochrome C family Cytochrom_c3_2 PF14537.1 EPA04453.1 - 0.018 15.4 1.9 0.019 15.2 1.3 1.1 1 0 0 1 1 1 0 Cytochrome c3 Cytochrome_C7 PF14522.1 EPA04453.1 - 0.018 14.6 0.6 0.019 14.6 0.4 1.1 1 0 0 1 1 1 0 Cytochrome c7 DZR PF12773.2 EPA04453.1 - 0.032 14.0 1.0 0.037 13.8 0.7 1.2 1 0 0 1 1 1 0 Double zinc ribbon zf-RING_4 PF14570.1 EPA04453.1 - 0.17 11.4 1.7 0.22 11.1 1.2 1.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zinc-ribbons_6 PF07191.7 EPA04453.1 - 0.2 11.4 3.8 0.32 10.8 2.6 1.3 1 1 0 1 1 1 0 zinc-ribbons DUF1451 PF07295.6 EPA04453.1 - 0.28 10.9 2.6 0.28 10.9 1.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1451) DNA_RNApol_7kD PF03604.8 EPA04453.1 - 1.1 8.8 4.3 2.4 7.6 3.0 1.6 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit DUF2070 PF09843.4 EPA04454.1 - 3.2e-43 147.2 0.0 6.2e-43 146.3 0.0 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) SUI1 PF01253.17 EPA04455.1 - 2.9e-21 75.0 0.1 3.5e-21 74.8 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 TFIIB PF00382.14 EPA04456.1 - 8.5e-37 124.8 5.9 1e-17 63.6 0.9 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EPA04456.1 - 7.3e-11 41.2 1.7 1.2e-10 40.5 1.2 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding zf-ribbon_3 PF13248.1 EPA04456.1 - 0.00011 21.2 1.7 0.00021 20.3 1.2 1.4 1 0 0 1 1 1 1 zinc-ribbon domain Sigma70_r4 PF04545.11 EPA04456.1 - 0.0003 20.0 0.0 0.13 11.6 0.0 2.7 2 0 0 2 2 2 1 Sigma-70, region 4 Cyclin_N PF00134.18 EPA04456.1 - 0.0018 17.8 0.1 0.044 13.3 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 EPA04456.1 - 0.0023 17.8 0.0 0.58 10.0 0.0 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain HTH_AsnC-type PF13404.1 EPA04456.1 - 0.0055 16.2 0.1 0.23 11.0 0.0 2.8 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain DZR PF12773.2 EPA04456.1 - 0.014 15.2 1.0 0.028 14.2 0.7 1.5 1 0 0 1 1 1 0 Double zinc ribbon Ribosomal_S27 PF01599.14 EPA04456.1 - 0.035 13.9 1.5 0.08 12.7 1.0 1.6 1 0 0 1 1 1 0 Ribosomal protein S27a HTH_23 PF13384.1 EPA04456.1 - 0.077 12.6 0.3 0.88 9.3 0.0 2.7 2 1 1 3 3 3 0 Homeodomain-like domain Lar_restr_allev PF14354.1 EPA04456.1 - 0.083 13.2 1.1 0.2 11.9 0.4 1.9 2 0 0 2 2 2 0 Restriction alleviation protein Lar HypA PF01155.14 EPA04456.1 - 0.2 11.3 0.9 3.1 7.5 0.3 2.4 2 1 0 2 2 2 0 Hydrogenase expression/synthesis hypA family LacI PF00356.16 EPA04456.1 - 0.26 10.9 1.3 1.6 8.4 0.1 2.8 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family zinc_ribbon_2 PF13240.1 EPA04456.1 - 1.4 8.5 8.7 8.1 6.0 6.1 2.1 1 1 0 1 1 1 0 zinc-ribbon domain NOB1_Zn_bind PF08772.6 EPA04456.1 - 1.6 8.5 5.3 9.2 6.1 0.1 2.5 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-NADH-PPase PF09297.6 EPA04456.1 - 2 8.0 10.1 1 8.9 0.5 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain DUF2479 PF10651.4 EPA04457.1 - 0.016 14.6 0.3 0.032 13.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2479) Mrr_cat PF04471.7 EPA04458.1 - 0.00047 19.9 0.0 0.00081 19.1 0.0 1.4 1 0 0 1 1 1 1 Restriction endonuclease NERD PF08378.6 EPA04458.1 - 0.028 14.6 0.1 0.047 13.9 0.1 1.4 1 0 0 1 1 1 0 Nuclease-related domain Rhodanese PF00581.15 EPA04458.1 - 0.13 12.6 0.0 5.1 7.4 0.0 2.3 2 0 0 2 2 2 0 Rhodanese-like domain zf-C2H2_4 PF13894.1 EPA04459.1 - 0.061 13.6 0.5 1.1 9.7 0.0 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger IMS PF00817.15 EPA04460.1 - 2e-40 138.0 0.1 1.9e-39 134.8 0.0 2.1 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.3 EPA04460.1 - 8.9e-17 61.2 1.5 2.4e-16 59.8 0.4 1.9 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 EPA04460.1 - 7.3e-08 32.0 0.0 1.9e-07 30.6 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif Cdd1 PF11731.3 EPA04460.1 - 0.0088 15.9 0.3 0.074 12.9 0.0 2.6 3 2 0 3 3 3 1 Pathogenicity locus DNA_pol_lambd_f PF10391.4 EPA04460.1 - 0.027 13.9 0.1 0.083 12.4 0.0 1.8 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda DUF4055 PF13264.1 EPA04460.1 - 0.1 12.6 0.5 5.2 7.1 0.1 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4055) DUF2524 PF10732.4 EPA04460.1 - 0.42 10.7 3.2 1.4 9.0 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) NPV_P10 PF05531.7 EPA04460.1 - 1.6 9.0 5.0 21 5.4 1.1 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.5 EPA04460.1 - 1.9 8.5 7.3 1.9 8.6 3.8 1.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF3797 PF12677.2 EPA04461.1 - 0.033 13.8 0.4 0.051 13.1 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) zf-Mss51 PF13824.1 EPA04461.1 - 0.11 12.4 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Adeno_100 PF02438.11 EPA04461.1 - 0.13 10.4 0.0 0.14 10.3 0.0 1.0 1 0 0 1 1 1 0 Late 100kD protein zf-ribbon_3 PF13248.1 EPA04461.1 - 0.2 10.9 1.4 0.43 9.8 1.0 1.7 1 1 0 1 1 1 0 zinc-ribbon domain zf-ISL3 PF14690.1 EPA04461.1 - 0.28 11.2 1.2 0.86 9.6 0.8 2.0 1 1 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-C2H2 PF00096.21 EPA04461.1 - 0.4 11.1 0.3 0.4 11.1 0.2 1.9 2 1 0 2 2 2 0 Zinc finger, C2H2 type zf-Di19 PF05605.7 EPA04461.1 - 0.61 10.2 2.2 0.85 9.7 0.3 1.9 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Herpes_UL31 PF02718.9 EPA04462.1 - 0.1 11.2 0.7 0.12 11.0 0.5 1.0 1 0 0 1 1 1 0 Herpesvirus UL31-like protein adh_short_C2 PF13561.1 EPA04464.1 - 6.2e-40 137.4 0.4 7.6e-40 137.1 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EPA04464.1 - 4.6e-33 114.4 0.0 5.7e-33 114.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EPA04464.1 - 3.6e-09 36.5 0.0 5e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EPA04464.1 - 2.4e-06 27.6 0.0 3.2e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EPA04464.1 - 4.2e-05 23.1 1.0 4.2e-05 23.1 0.7 1.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 EPA04464.1 - 0.00013 22.3 1.0 0.00024 21.4 0.3 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.13 EPA04464.1 - 0.00057 19.5 0.2 0.00093 18.8 0.2 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DFP PF04127.10 EPA04464.1 - 0.0047 16.5 0.2 0.0078 15.8 0.1 1.4 1 1 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein Polysacc_synt_2 PF02719.10 EPA04464.1 - 0.0073 15.2 2.2 0.0095 14.8 1.5 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein AdoHcyase_NAD PF00670.16 EPA04464.1 - 0.13 12.0 1.3 1.5 8.6 0.0 2.4 2 1 1 3 3 3 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF99 PF01949.11 EPA04466.1 - 8.3e-57 191.3 0.0 9.2e-57 191.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF99 DUF2608 PF11019.3 EPA04466.1 - 0.14 11.1 1.2 0.17 10.8 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) NAD_binding_2 PF03446.10 EPA04467.1 - 2.6e-39 134.6 0.8 4.5e-39 133.9 0.6 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 EPA04467.1 - 4.8e-20 71.8 0.0 8e-20 71.1 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.15 EPA04467.1 - 2.4e-07 30.9 0.4 4.6e-07 30.0 0.3 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 EPA04467.1 - 4.6e-07 30.1 1.1 1e-06 29.0 0.4 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_N PF03721.9 EPA04467.1 - 3.6e-06 26.4 1.2 0.001 18.4 0.1 2.4 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.14 EPA04467.1 - 3.3e-05 23.1 0.1 6.2e-05 22.2 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.11 EPA04467.1 - 4.3e-05 22.9 0.1 7.5e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.13 EPA04467.1 - 5.9e-05 22.8 0.5 0.0012 18.4 0.2 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Rossmann-like PF10727.4 EPA04467.1 - 8.1e-05 22.3 0.1 0.009 15.7 0.1 2.2 1 1 1 2 2 2 1 Rossmann-like domain NAD_Gly3P_dh_N PF01210.18 EPA04467.1 - 0.00014 21.6 0.1 0.00056 19.6 0.0 2.0 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus IlvN PF07991.7 EPA04467.1 - 0.00021 20.6 0.2 0.00051 19.4 0.1 1.7 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain FAD_binding_3 PF01494.14 EPA04467.1 - 0.022 13.8 0.1 0.032 13.2 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_7 PF13241.1 EPA04467.1 - 0.062 13.5 0.2 0.18 12.0 0.1 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_10 PF13460.1 EPA04467.1 - 0.077 12.9 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 NADH(P)-binding HAUS5 PF14817.1 EPA04467.1 - 0.19 10.2 0.0 0.3 9.5 0.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 DUF1752 PF08550.5 EPA04468.1 - 0.027 14.0 0.5 0.042 13.4 0.4 1.4 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1752) FAD_oxidored PF12831.2 EPA04469.1 - 4e-16 59.1 0.0 5.4e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 EPA04469.1 - 5.4e-15 55.2 0.0 1.9e-14 53.5 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 EPA04469.1 - 1.1e-14 54.2 1.0 2.4e-08 33.3 0.3 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Trp_halogenase PF04820.9 EPA04469.1 - 1.6e-12 46.8 0.2 2.3e-07 29.8 0.0 2.2 1 1 1 2 2 2 2 Tryptophan halogenase FAD_binding_2 PF00890.19 EPA04469.1 - 3.7e-11 42.5 0.4 4.5e-07 29.0 0.1 2.1 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.7 EPA04469.1 - 3.4e-09 36.0 0.0 5.6e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 EPA04469.1 - 2.1e-08 34.2 1.6 4.8e-08 33.1 1.1 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EPA04469.1 - 2.7e-08 32.6 0.4 2.7e-06 26.1 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein Thi4 PF01946.12 EPA04469.1 - 1.6e-07 30.6 1.4 9.4e-06 24.8 0.1 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.1 EPA04469.1 - 1.9e-06 27.7 0.1 7.3e-06 25.9 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EPA04469.1 - 2.1e-06 27.9 0.1 2.9e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EPA04469.1 - 2.5e-06 26.6 0.6 8.4e-06 24.8 0.2 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.22 EPA04469.1 - 4.3e-05 23.8 0.8 0.015 15.7 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 EPA04469.1 - 0.024 14.3 0.1 0.042 13.5 0.1 1.6 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.13 EPA04469.1 - 0.11 12.4 0.1 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain GMC_oxred_N PF00732.14 EPA04469.1 - 0.12 11.4 0.2 1 8.4 0.0 2.0 2 0 0 2 2 2 0 GMC oxidoreductase Auto_anti-p27 PF06677.7 EPA04470.1 - 8.1e-08 31.9 1.9 1.2e-07 31.3 1.3 1.3 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF1178 PF06676.6 EPA04470.1 - 0.017 15.3 0.4 0.02 15.1 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) Abi_C PF14355.1 EPA04470.1 - 0.048 13.5 0.7 0.087 12.7 0.5 1.4 1 0 0 1 1 1 0 Abortive infection C-terminus TIP120 PF08623.5 EPA04470.1 - 0.055 13.0 4.0 0.065 12.8 2.8 1.1 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) zf-C4pol PF14260.1 EPA04470.1 - 0.93 9.5 3.8 4.8 7.2 2.6 2.2 1 1 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta UPF0052 PF01933.13 EPA04471.1 - 4.1e-48 164.2 0.0 5.1e-48 163.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 zf-H2C2_5 PF13909.1 EPA04472.1 - 0.0006 19.8 1.6 0.001 19.1 1.1 1.3 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.21 EPA04472.1 - 0.00095 19.3 1.2 0.0017 18.6 0.8 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EPA04472.1 - 0.0014 18.8 0.8 0.0022 18.1 0.5 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger DUF3505 PF12013.3 EPA04472.1 - 0.072 13.3 0.0 0.083 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3505) TF_Zn_Ribbon PF08271.7 EPA04472.1 - 0.087 12.1 0.2 0.18 11.1 0.1 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding PolC_DP2 PF03833.8 EPA04473.1 - 0.061 10.9 2.1 0.058 11.0 1.4 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-HC5HC2H_2 PF13832.1 EPA04473.1 - 0.1 12.6 4.4 0.11 12.4 3.1 1.1 1 0 0 1 1 1 0 PHD-zinc-finger like domain DZR PF12773.2 EPA04473.1 - 0.11 12.2 7.2 0.18 11.6 5.0 1.3 1 0 0 1 1 1 0 Double zinc ribbon DNA_RNApol_7kD PF03604.8 EPA04473.1 - 2.8 7.4 8.6 13 5.3 0.0 3.0 2 1 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Fer4_2 PF12797.2 EPA04473.1 - 8.4 6.5 9.2 7.4 6.7 1.3 2.3 1 1 1 2 2 2 0 4Fe-4S binding domain Methyltransf_23 PF13489.1 EPA04474.1 - 6.5e-20 71.4 0.0 8.4e-20 71.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA04474.1 - 1.1e-19 70.7 0.0 3.2e-19 69.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA04474.1 - 5.8e-18 64.9 2.3 8.3e-18 64.4 1.6 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA04474.1 - 1.2e-16 60.9 0.0 4.3e-16 59.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA04474.1 - 2.6e-12 47.3 0.0 4.7e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EPA04474.1 - 4.8e-11 42.9 0.0 1.1e-10 41.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain NodS PF05401.6 EPA04474.1 - 1e-10 41.3 0.0 1.3e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_9 PF08003.6 EPA04474.1 - 2.1e-10 39.8 0.1 4.1e-10 38.8 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_4 PF02390.12 EPA04474.1 - 2.4e-10 39.7 1.2 1.9e-07 30.3 0.0 2.1 2 0 0 2 2 2 2 Putative methyltransferase Ubie_methyltran PF01209.13 EPA04474.1 - 1.5e-09 37.2 1.2 2e-09 36.8 0.8 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.7 EPA04474.1 - 1.8e-06 27.4 0.1 1.2e-05 24.8 0.0 1.9 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW DOT1 PF08123.8 EPA04474.1 - 1.3e-05 24.5 0.1 0.00022 20.5 0.0 2.1 1 1 0 2 2 2 1 Histone methylation protein DOT1 CMAS PF02353.15 EPA04474.1 - 6.8e-05 22.0 0.7 8.8e-05 21.7 0.5 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase AdoMet_MTase PF07757.8 EPA04474.1 - 8e-05 22.7 1.4 0.00016 21.7 0.0 2.0 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase MTS PF05175.9 EPA04474.1 - 0.00034 20.0 0.0 0.00059 19.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain GidB PF02527.10 EPA04474.1 - 0.00052 19.1 0.1 0.0011 18.0 0.0 1.7 1 1 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_32 PF13679.1 EPA04474.1 - 0.0007 19.2 0.2 0.0038 16.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DREV PF05219.7 EPA04474.1 - 0.00079 18.3 0.2 0.0011 17.8 0.2 1.3 1 1 0 1 1 1 1 DREV methyltransferase TehB PF03848.9 EPA04474.1 - 0.0018 17.4 0.3 0.0036 16.4 0.1 1.3 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_26 PF13659.1 EPA04474.1 - 0.0032 17.4 0.0 0.0067 16.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EPA04474.1 - 0.027 14.0 0.0 0.055 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Sec61_beta PF03911.11 EPA04475.1 - 2.4e-14 52.8 0.4 2.8e-14 52.6 0.3 1.1 1 0 0 1 1 1 1 Sec61beta family Abi PF02517.11 EPA04476.1 - 5.8e-10 39.1 23.7 1.2e-08 34.9 16.4 2.7 1 1 0 1 1 1 1 CAAX protease self-immunity Exosortase_EpsH PF09721.5 EPA04477.1 - 6.8e-05 22.2 27.2 0.00013 21.2 18.7 1.5 1 1 0 1 1 1 1 Transmembrane exosortase (Exosortase_EpsH) DUF4231 PF14015.1 EPA04477.1 - 5.1 7.1 8.3 0.41 10.6 1.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Peripla_BP_2 PF01497.13 EPA04479.1 - 1.1e-46 158.9 0.0 1.3e-46 158.6 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein Ribosomal_L17 PF01196.14 EPA04479.1 - 0.097 13.2 0.1 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L17 DUF650 PF04894.7 EPA04480.1 - 4.3e-89 298.6 0.0 5.6e-89 298.2 0.0 1.1 1 0 0 1 1 1 1 Archaeal protein of unknown function (DUF650) DUF651 PF04895.7 EPA04480.1 - 2.9e-35 120.2 0.0 4.5e-35 119.5 0.0 1.3 1 0 0 1 1 1 1 Archaeal protein of unknown function (DUF651) ADH_zinc_N PF00107.21 EPA04481.1 - 4.2e-29 100.7 0.0 6.3e-29 100.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EPA04481.1 - 4.3e-17 63.1 0.0 8.5e-17 62.2 0.0 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ACP_syn_III_C PF08541.5 EPA04481.1 - 0.0092 15.9 0.2 0.025 14.5 0.0 1.8 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal TPR_1 PF00515.23 EPA04482.1 - 4.4e-08 32.3 3.7 0.00012 21.5 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 EPA04482.1 - 6.5e-08 32.1 0.3 8e-08 31.8 0.2 1.1 1 0 0 1 1 1 1 TPR repeat TPR_16 PF13432.1 EPA04482.1 - 4.8e-05 23.9 0.0 5.3e-05 23.7 0.0 1.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 EPA04482.1 - 9e-05 22.1 1.6 0.001 18.8 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 EPA04482.1 - 0.0027 17.6 0.3 0.0046 16.8 0.2 1.4 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.1 EPA04482.1 - 0.0065 16.1 1.4 1.9 8.4 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 EPA04482.1 - 0.011 16.1 0.1 0.026 14.9 0.0 1.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 EPA04482.1 - 0.012 15.7 1.3 0.13 12.5 0.3 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.7 EPA04482.1 - 0.017 14.8 0.6 0.027 14.2 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.1 EPA04482.1 - 0.042 13.8 0.0 9.4 6.3 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.1 EPA04482.1 - 0.043 13.6 0.0 0.046 13.5 0.0 1.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.1 EPA04482.1 - 0.044 14.1 0.0 0.056 13.7 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat Apc3 PF12895.2 EPA04482.1 - 0.051 13.7 0.0 0.052 13.6 0.0 1.0 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 SSXT PF05030.7 EPA04482.1 - 0.065 12.8 0.1 0.21 11.1 0.1 1.8 1 1 0 1 1 1 0 SSXT protein (N-terminal region) Chlor_dismutase PF06778.7 EPA04483.1 - 1.6e-48 164.9 0.3 1.8e-48 164.8 0.2 1.0 1 0 0 1 1 1 1 Chlorite dismutase DUF1802 PF08819.6 EPA04484.1 - 8.1e-47 159.0 0.4 9.2e-47 158.9 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1802) Copper-bind PF00127.15 EPA04485.1 - 2.3e-17 63.0 1.9 4.3e-09 36.5 0.1 2.5 2 0 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 EPA04485.1 - 8.7e-14 51.2 0.0 7.9e-06 25.7 0.0 2.6 2 0 0 2 2 2 2 Cupredoxin-like domain Trypan_PARP PF05887.6 EPA04485.1 - 1.6 8.5 25.6 0.18 11.6 11.2 2.8 2 1 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) PLRV_ORF5 PF01690.12 EPA04485.1 - 2.4 7.1 17.5 4.9 6.1 12.1 1.4 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Hint_2 PF13403.1 EPA04486.1 - 4.8e-07 29.8 0.2 1.1e-05 25.3 0.1 2.2 1 1 1 2 2 2 2 Hint domain PT-HINT PF07591.6 EPA04486.1 - 0.0056 16.5 0.2 0.0097 15.7 0.1 1.4 1 0 0 1 1 1 1 Pretoxin HINT domain Vint PF14623.1 EPA04486.1 - 0.1 12.0 0.1 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 Hint-domain DUF524 PF04411.7 EPA04487.1 - 0.0005 19.9 0.8 0.021 14.6 0.6 2.7 1 1 0 1 1 1 1 Protein of unknown function (DUF524) DUF4513 PF14983.1 EPA04488.1 - 0.067 13.0 0.0 0.084 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4513) DnaJ_CXXCXGXG PF00684.14 EPA04488.1 - 0.072 13.1 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 DnaJ central domain DNA_RNApol_7kD PF03604.8 EPA04488.1 - 2.6 7.5 6.3 1.8 8.0 2.7 2.0 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit AAA_5 PF07728.9 EPA04489.1 - 2.5e-13 49.9 0.0 5.9e-13 48.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Copper-bind PF00127.15 EPA04489.1 - 2.5e-06 27.6 1.0 0.0001 22.4 0.1 2.9 2 0 0 2 2 2 1 Copper binding proteins, plastocyanin/azurin family AAA_3 PF07726.6 EPA04489.1 - 0.003 17.1 0.0 2 8.0 0.0 3.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EPA04489.1 - 0.0033 17.1 0.1 0.0087 15.7 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain Mg_chelatase PF01078.16 EPA04489.1 - 0.0036 16.5 0.0 0.012 14.7 0.0 1.9 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Cupredoxin_1 PF13473.1 EPA04489.1 - 0.016 15.0 0.0 0.04 13.8 0.0 1.7 1 0 0 1 1 1 0 Cupredoxin-like domain AAA_16 PF13191.1 EPA04489.1 - 0.031 14.2 0.0 0.2 11.6 0.0 2.3 3 0 0 3 3 3 0 AAA ATPase domain RuvB_N PF05496.7 EPA04489.1 - 0.034 13.2 0.0 0.073 12.1 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.1 EPA04489.1 - 0.04 14.2 0.7 0.79 10.0 0.0 3.2 3 0 0 3 3 3 0 AAA domain TIP49 PF06068.8 EPA04489.1 - 0.059 12.0 0.0 0.1 11.2 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_22 PF13401.1 EPA04489.1 - 0.086 12.9 0.0 0.4 10.8 0.0 2.2 1 1 0 1 1 1 0 AAA domain zf-LYAR PF08790.6 EPA04490.1 - 0.0016 18.0 0.5 0.78 9.4 0.0 2.3 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger zf-C2H2 PF00096.21 EPA04490.1 - 0.032 14.5 6.5 0.083 13.2 0.1 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 EPA04490.1 - 0.2 11.6 3.9 6.1 6.9 0.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.2 EPA04490.1 - 0.36 10.9 7.1 3.3 7.8 0.3 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.1 EPA04490.1 - 2 8.8 8.8 3.5 8.1 0.0 2.7 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 EPA04490.1 - 2.4 8.6 4.2 13 6.3 0.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger AstA PF04958.7 EPA04491.1 - 0.064 11.6 0.0 0.064 11.6 0.0 1.0 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit DUF2107 PF09880.4 EPA04492.1 - 0.0079 16.0 2.6 0.0092 15.8 1.8 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2107) CRPA PF05745.6 EPA04492.1 - 0.012 15.4 5.7 0.013 15.2 3.9 1.0 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) BofA PF07441.6 EPA04492.1 - 0.03 14.2 2.8 0.05 13.6 1.9 1.4 1 1 0 1 1 1 0 SigmaK-factor processing regulatory protein BofA TrbC PF04956.8 EPA04492.1 - 0.035 14.1 1.6 0.042 13.8 1.1 1.1 1 0 0 1 1 1 0 TrbC/VIRB2 family EcsB PF05975.7 EPA04492.1 - 0.055 11.9 1.2 0.061 11.7 0.9 1.0 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB Fst_toxin PF13955.1 EPA04492.1 - 0.072 12.7 3.1 0.072 12.7 2.2 2.2 2 0 0 2 2 2 0 Toxin Fst, type I toxin-antitoxin system TctB PF07331.6 EPA04492.1 - 0.091 12.4 5.5 0.36 10.4 3.8 1.7 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family BCCT PF02028.12 EPA04492.1 - 0.096 10.9 1.9 0.1 10.7 1.3 1.0 1 0 0 1 1 1 0 BCCT family transporter DUF3185 PF11381.3 EPA04492.1 - 0.1 12.3 2.6 2.4 7.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) DUF1129 PF06570.6 EPA04492.1 - 0.48 9.7 2.8 0.47 9.7 1.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Tetraspannin PF00335.15 EPA04492.1 - 0.69 9.1 2.6 0.74 9.0 1.8 1.0 1 0 0 1 1 1 0 Tetraspanin family SdpI PF13630.1 EPA04492.1 - 1.9 8.2 5.2 2.2 8.0 3.6 1.2 1 0 0 1 1 1 0 SdpI/YhfL protein family Flavi_NS2B PF01002.14 EPA04492.1 - 9.7 5.7 6.3 35 3.9 4.4 1.8 1 1 0 1 1 1 0 Flavivirus non-structural protein NS2B Peripla_BP_4 PF13407.1 EPA04494.1 - 2.8e-11 43.2 0.0 3.3e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein domain NYN PF01936.13 EPA04494.1 - 0.0047 17.2 0.0 0.013 15.7 0.0 1.7 2 0 0 2 2 2 1 NYN domain Peripla_BP_3 PF13377.1 EPA04494.1 - 0.081 12.9 0.0 0.34 10.8 0.0 1.8 2 0 0 2 2 2 0 Periplasmic binding protein-like domain PGM_PMM_II PF02879.11 EPA04494.1 - 0.1 12.9 0.0 2.8 8.3 0.0 3.0 2 1 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II DUF72 PF01904.13 EPA04495.1 - 1.4e-48 165.6 0.0 1.6e-48 165.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF72 OPA3 PF07047.7 EPA04496.1 - 0.00022 20.9 0.0 0.00023 20.9 0.0 1.1 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) IncA PF04156.9 EPA04496.1 - 0.00082 19.0 0.0 0.0013 18.4 0.0 1.2 1 1 0 1 1 1 1 IncA protein SieB PF14163.1 EPA04496.1 - 0.0014 18.1 0.7 0.0019 17.7 0.5 1.1 1 0 0 1 1 1 1 Superinfection exclusion protein B Vpu PF00558.14 EPA04496.1 - 0.0015 18.0 0.8 0.0015 18.0 0.6 2.0 2 0 0 2 2 2 1 Vpu protein DivIC PF04977.10 EPA04496.1 - 0.0016 17.8 0.3 0.0016 17.8 0.2 1.6 2 0 0 2 2 1 1 Septum formation initiator 7tm_1 PF00001.16 EPA04496.1 - 0.0019 17.3 6.3 0.035 13.2 0.1 2.0 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) O-ag_pol_Wzy PF14296.1 EPA04496.1 - 0.0091 14.6 3.4 0.013 14.0 2.4 1.2 1 0 0 1 1 1 1 O-antigen polysaccharide polymerase Wzy EphA2_TM PF14575.1 EPA04496.1 - 0.01 16.2 1.8 0.015 15.6 0.0 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF1049 PF06305.6 EPA04496.1 - 0.015 14.7 0.6 0.035 13.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) 7TM_GPCR_Sra PF02117.11 EPA04496.1 - 0.021 13.4 1.6 0.022 13.3 1.1 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sra Sre PF03125.13 EPA04496.1 - 0.022 13.7 0.6 0.024 13.5 0.4 1.1 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor gpUL132 PF11359.3 EPA04496.1 - 0.023 14.0 0.0 0.028 13.7 0.0 1.1 1 0 0 1 1 1 0 Glycoprotein UL132 MSC PF09402.5 EPA04496.1 - 0.023 13.4 0.2 0.023 13.4 0.2 1.3 1 1 0 1 1 1 0 Man1-Src1p-C-terminal domain Ly49 PF08391.5 EPA04496.1 - 0.032 14.3 0.1 0.032 14.3 0.1 1.6 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region CcmH PF03918.9 EPA04496.1 - 0.041 12.8 0.0 0.075 12.0 0.0 1.5 1 1 0 1 1 1 0 Cytochrome C biogenesis protein ST7 PF04184.7 EPA04496.1 - 0.054 11.7 0.2 0.055 11.7 0.1 1.0 1 0 0 1 1 1 0 ST7 protein Chordopox_A13L PF05961.6 EPA04496.1 - 0.062 13.2 0.3 0.062 13.2 0.2 1.6 2 0 0 2 2 1 0 Chordopoxvirus A13L protein Virul_fac_BrkB PF03631.10 EPA04496.1 - 0.062 12.6 2.1 0.072 12.4 1.5 1.0 1 0 0 1 1 1 0 Virulence factor BrkB BatD PF13584.1 EPA04496.1 - 0.063 11.8 0.2 0.07 11.7 0.0 1.2 1 1 0 1 1 1 0 Oxygen tolerance GRIM-19 PF06212.7 EPA04496.1 - 0.078 12.6 0.0 0.093 12.4 0.0 1.2 1 0 0 1 1 1 0 GRIM-19 protein ABC2_membrane_4 PF12730.2 EPA04496.1 - 0.079 12.1 5.7 0.095 11.8 4.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein SUR7 PF06687.7 EPA04496.1 - 0.097 12.2 0.5 0.11 12.0 0.3 1.0 1 0 0 1 1 1 0 SUR7/PalI family ETRAMP PF09716.5 EPA04496.1 - 0.11 12.4 7.2 0.19 11.7 5.0 1.5 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) 2TM PF13239.1 EPA04496.1 - 0.13 12.2 0.4 0.19 11.7 0.3 1.3 1 0 0 1 1 1 0 2TM domain DUF3169 PF11368.3 EPA04496.1 - 0.16 11.1 7.7 0.51 9.4 5.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3169) Glycophorin_A PF01102.13 EPA04496.1 - 0.17 11.6 0.0 0.17 11.6 0.0 1.4 2 0 0 2 2 1 0 Glycophorin A DUF3816 PF12822.2 EPA04496.1 - 0.29 10.9 8.5 0.67 9.8 5.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) TMEM154 PF15102.1 EPA04496.1 - 0.56 9.9 7.1 1.3 8.6 4.9 1.7 1 1 0 1 1 1 0 TMEM154 protein family COPI_assoc PF08507.5 EPA04496.1 - 0.76 9.4 6.4 1.1 8.9 4.4 1.2 1 0 0 1 1 1 0 COPI associated protein DUF3139 PF11337.3 EPA04496.1 - 3.9 7.8 9.6 1.6 9.0 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3139) DUF3290 PF11694.3 EPA04496.1 - 4.2 7.1 6.4 0.9 9.2 0.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3290) YajC PF02699.10 EPA04496.1 - 4.2 7.1 8.6 0.21 11.3 0.8 2.3 2 1 0 2 2 2 0 Preprotein translocase subunit DUF2207 PF09972.4 EPA04496.1 - 4.5 5.7 6.6 9.4 4.6 4.5 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Pmp3 PF01679.12 EPA04496.1 - 6.7 6.4 11.3 1.4 8.6 1.8 2.2 2 0 0 2 2 2 0 Proteolipid membrane potential modulator DUF2417 PF10329.4 EPA04496.1 - 9.1 5.6 9.6 12 5.2 6.6 1.2 1 0 0 1 1 1 0 Region of unknown function (DUF2417) ABC2_membrane_4 PF12730.2 EPA04498.1 - 0.00029 20.0 4.2 0.00033 19.9 2.9 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein Trep_Strep PF09605.5 EPA04498.1 - 0.08 12.6 1.8 0.098 12.3 1.2 1.1 1 0 0 1 1 1 0 Hypothetical bacterial integral membrane protein (Trep_Strep) DUF2839 PF10999.3 EPA04498.1 - 7.4 6.6 5.8 1.2 9.2 0.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2839) Response_reg PF00072.19 EPA04499.1 - 7.1e-24 83.9 2.7 7.9e-24 83.8 1.8 1.0 1 0 0 1 1 1 1 Response regulator receiver domain FleQ PF06490.6 EPA04499.1 - 0.013 15.5 0.2 0.025 14.7 0.1 1.7 1 1 0 1 1 1 0 Flagellar regulatory protein FleQ B12-binding PF02310.14 EPA04499.1 - 0.017 14.9 0.0 0.031 14.1 0.0 1.4 1 1 0 1 1 1 0 B12 binding domain TrkA_N PF02254.13 EPA04499.1 - 0.066 13.2 2.0 0.15 12.1 1.4 1.6 1 1 0 1 1 1 0 TrkA-N domain Radical_SAM PF04055.16 EPA04501.1 - 1e-19 71.2 0.1 4.1e-19 69.3 0.0 1.8 1 1 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.7 EPA04501.1 - 1.3e-19 70.0 0.0 2.3e-18 66.0 0.0 2.6 2 0 0 2 2 2 1 Wyosine base formation SAS4 PF15460.1 EPA04501.1 - 0.0018 18.0 0.7 0.0039 17.0 0.3 1.9 1 1 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 Fer4_14 PF13394.1 EPA04501.1 - 0.0031 17.5 0.1 0.019 14.9 0.1 2.2 1 1 0 1 1 1 1 4Fe-4S single cluster domain AAT PF03417.11 EPA04501.1 - 0.052 13.0 0.1 0.1 12.0 0.0 1.5 1 1 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Peptidase_M26_N PF05342.9 EPA04501.1 - 0.063 12.2 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 M26 IgA1-specific Metallo-endopeptidase N-terminal region Fer4_12 PF13353.1 EPA04501.1 - 0.068 13.2 0.3 0.3 11.1 0.2 2.1 1 1 0 1 1 1 0 4Fe-4S single cluster domain Peptidase_M22 PF00814.20 EPA04502.1 - 5e-75 252.4 0.0 5.9e-75 252.2 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family CmcH_NodU PF02543.10 EPA04502.1 - 0.13 11.3 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Carbamoyltransferase DUF3000 PF11452.3 EPA04503.1 - 0.14 11.4 0.3 0.13 11.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3000) Lactamase_B PF00753.22 EPA04504.1 - 1.6e-16 60.5 0.2 4.7e-16 59.0 0.2 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EPA04504.1 - 7.3e-14 51.7 0.0 9.8e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 EPA04504.1 - 1.7e-05 24.5 0.0 5e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta-Casp PF10996.3 EPA04504.1 - 0.041 13.8 0.0 0.071 13.0 0.0 1.4 1 0 0 1 1 1 0 Beta-Casp domain DUF2220 PF09983.4 EPA04504.1 - 0.082 12.0 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) TSP_3 PF02412.13 EPA04505.1 - 5.8e-07 28.8 10.1 0.00013 21.3 1.8 3.5 3 1 0 3 3 3 2 Thrombospondin type 3 repeat DUF282 PF03380.9 EPA04505.1 - 0.00068 19.3 0.4 1.2 8.9 0.1 2.6 2 0 0 2 2 2 2 Caenorhabditis protein of unknown function, DUF282 Excalibur PF05901.6 EPA04505.1 - 0.00091 19.5 5.4 0.083 13.2 0.0 3.4 4 0 0 4 4 4 2 Excalibur calcium-binding domain Fer4_15 PF13459.1 EPA04505.1 - 0.37 11.4 3.4 1.2 9.7 0.1 2.4 1 1 1 2 2 2 0 4Fe-4S single cluster domain FG-GAP PF01839.18 EPA04505.1 - 0.51 10.0 5.5 5 6.9 0.6 3.1 2 1 0 2 2 2 0 FG-GAP repeat VCBS PF13517.1 EPA04505.1 - 1.2 9.5 4.3 8.3 6.8 0.1 2.9 2 1 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DoxA PF07680.6 EPA04506.1 - 0.016 14.7 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 TQO small subunit DoxA Lipocalin PF00061.18 EPA04506.1 - 0.075 13.0 0.0 0.099 12.6 0.0 1.2 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family Rax2 PF12768.2 EPA04507.1 - 0.0022 17.2 0.2 0.0022 17.2 0.1 1.0 1 0 0 1 1 1 1 Cortical protein marker for cell polarity DUF2834 PF11196.3 EPA04507.1 - 0.022 14.8 0.0 0.022 14.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2834) Romo1 PF10247.4 EPA04507.1 - 0.03 14.5 0.1 0.033 14.3 0.1 1.1 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 SKG6 PF08693.5 EPA04507.1 - 0.044 13.1 0.1 0.055 12.7 0.1 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF2453 PF10507.4 EPA04507.1 - 0.063 13.0 0.1 0.064 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2453) MtrG PF04210.8 EPA04507.1 - 0.066 12.8 1.1 0.075 12.7 0.8 1.2 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G Mid2 PF04478.7 EPA04507.1 - 0.09 12.1 0.2 0.09 12.1 0.2 1.1 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor MMR_HSR1_C PF08438.5 EPA04508.1 - 2.3e-30 105.0 0.4 5.8e-30 103.7 0.1 1.8 2 0 0 2 2 2 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 EPA04508.1 - 1.9e-17 63.2 0.0 2.3e-16 59.7 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 EPA04508.1 - 1.7e-12 46.9 0.2 4.4e-12 45.6 0.1 1.7 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 EPA04508.1 - 3.9e-06 26.2 0.1 1.6e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B YchF-GTPase_C PF06071.8 EPA04508.1 - 0.028 14.1 1.2 0.08 12.7 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF933) Cation_efflux PF01545.16 EPA04509.1 - 1.6e-46 158.6 6.8 1.8e-46 158.5 4.7 1.0 1 0 0 1 1 1 1 Cation efflux family DUF1212 PF06738.7 EPA04509.1 - 6.5 6.1 8.6 8.9 5.7 0.2 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1212) Cytochrom_B_N_2 PF13631.1 EPA04510.1 - 1.9e-24 86.3 7.1 1.9e-24 86.3 4.9 3.9 3 1 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.12 EPA04510.1 - 2.1e-08 34.2 1.7 2.1e-08 34.2 1.2 3.2 4 0 0 4 4 4 1 Cytochrome b(C-terminal)/b6/petD DUF4405 PF14358.1 EPA04510.1 - 0.0018 18.3 3.1 0.0018 18.3 2.1 3.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4405) TSP_3 PF02412.13 EPA04511.1 - 2.6e-56 186.7 232.0 1.2e-05 24.6 1.0 25.8 21 10 4 25 25 25 20 Thrombospondin type 3 repeat DUF282 PF03380.9 EPA04511.1 - 6.4e-10 38.6 32.0 4.2 7.1 0.1 14.0 15 0 0 15 15 15 5 Caenorhabditis protein of unknown function, DUF282 HhH-GPD PF00730.20 EPA04512.1 - 2e-09 37.6 0.0 2.7e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein OGG_N PF07934.7 EPA04513.1 - 8.6e-16 57.9 0.3 1.5e-14 53.9 0.2 2.0 1 1 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain RNA_helicase PF00910.17 EPA04513.1 - 0.005 16.9 0.2 0.0079 16.3 0.1 1.4 1 0 0 1 1 1 1 RNA helicase DUF2674 PF10879.3 EPA04513.1 - 0.39 10.4 2.3 3.5 7.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2674) GRAM PF02893.15 EPA04514.1 - 0.0023 17.4 0.1 0.0074 15.7 0.0 2.0 2 1 0 2 2 2 1 GRAM domain bPH_3 PF14470.1 EPA04514.1 - 0.056 13.6 0.3 0.13 12.5 0.2 1.7 1 1 0 1 1 1 0 Bacterial PH domain TSP_3 PF02412.13 EPA04515.1 - 1.1e-14 53.6 47.6 0.00068 19.0 2.1 6.7 4 3 1 5 5 5 4 Thrombospondin type 3 repeat Fer4_13 PF13370.1 EPA04515.1 - 0.11 12.8 3.7 5.3 7.5 0.0 3.8 3 1 0 3 3 3 0 4Fe-4S single cluster domain DUF282 PF03380.9 EPA04515.1 - 0.19 11.5 2.9 4.7 7.0 0.1 3.6 4 0 0 4 4 4 0 Caenorhabditis protein of unknown function, DUF282 Excalibur PF05901.6 EPA04515.1 - 0.86 10.0 10.2 66 3.9 0.0 5.0 4 1 0 4 4 4 0 Excalibur calcium-binding domain EF-hand_5 PF13202.1 EPA04515.1 - 4.4 6.8 9.1 21 4.7 0.2 3.9 3 0 0 3 3 3 0 EF hand NOPS PF08075.6 EPA04515.1 - 8.8 6.8 14.6 6.1 7.3 0.1 4.4 5 0 0 5 5 5 0 NOPS (NUC059) domain RMMBL PF07521.7 EPA04516.1 - 8.9e-13 47.8 0.0 1.4e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Beta-Casp PF10996.3 EPA04516.1 - 4.6e-07 29.8 0.1 3.7e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 Beta-Casp domain DUF4023 PF13215.1 EPA04516.1 - 0.074 12.8 0.8 13 5.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4023) TGT PF01702.13 EPA04517.1 - 4.7e-48 163.5 0.0 7.1e-48 162.9 0.0 1.3 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Fer4 PF00037.22 EPA04518.1 - 1.7e-11 43.1 10.3 6.6e-06 25.5 0.3 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.2 EPA04518.1 - 2.1e-10 40.0 7.5 3.6e-05 23.4 1.0 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 EPA04518.1 - 1.2e-09 38.4 3.8 1.7e-09 37.8 2.6 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 EPA04518.1 - 5.7e-09 35.6 3.2 9.5e-09 34.9 2.3 1.4 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.2 EPA04518.1 - 8e-09 34.9 9.0 0.00011 21.9 1.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.1 EPA04518.1 - 4.2e-08 32.9 1.4 6.2e-08 32.3 1.0 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_13 PF13370.1 EPA04518.1 - 2.4e-06 27.8 4.9 0.008 16.5 1.0 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_15 PF13459.1 EPA04518.1 - 3.1e-06 27.6 8.7 0.00094 19.7 6.2 2.4 1 1 0 1 1 1 1 4Fe-4S single cluster domain Fer4_4 PF12800.2 EPA04518.1 - 1.7e-05 24.7 9.7 0.038 14.3 0.3 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.1 EPA04518.1 - 3.2e-05 24.0 6.9 0.00015 21.9 5.0 1.8 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_16 PF13484.1 EPA04518.1 - 8.1e-05 23.2 1.5 0.3 11.8 0.0 2.1 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_8 PF13183.1 EPA04518.1 - 0.00015 21.6 5.0 0.00042 20.2 3.4 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.2 EPA04518.1 - 0.0002 21.6 11.3 0.044 14.3 2.9 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.1 EPA04518.1 - 0.0023 18.2 6.4 0.05 13.9 4.4 2.1 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 EPA04518.1 - 0.0037 17.6 6.8 0.19 12.1 1.6 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain TSP_3 PF02412.13 EPA04519.1 - 2.7e-29 100.3 96.6 2.3e-05 23.7 2.0 12.5 10 4 2 12 12 12 8 Thrombospondin type 3 repeat DUF282 PF03380.9 EPA04519.1 - 0.0015 18.2 14.5 7.7 6.3 0.1 7.5 8 0 0 8 8 8 1 Caenorhabditis protein of unknown function, DUF282 NOPS PF08075.6 EPA04519.1 - 0.012 15.9 22.6 9.3 6.7 0.0 8.6 7 4 1 8 8 8 0 NOPS (NUC059) domain ChitinaseA_N PF08329.5 EPA04519.1 - 0.05 13.3 2.5 1.8 8.3 0.1 2.7 2 0 0 2 2 2 0 Chitinase A, N-terminal domain Excalibur PF05901.6 EPA04519.1 - 0.09 13.1 38.3 20 5.5 0.1 9.4 8 3 0 8 8 8 0 Excalibur calcium-binding domain RIO1 PF01163.17 EPA04520.1 - 1.5e-10 40.7 0.0 2e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.20 EPA04520.1 - 1.7e-09 37.2 0.2 2.2e-09 36.8 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 EPA04520.1 - 1.6e-08 33.8 0.1 1e-07 31.2 0.0 2.0 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EPA04520.1 - 1.9e-06 27.7 0.0 0.022 14.5 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 EPA04520.1 - 0.0003 19.9 0.5 0.0013 17.8 0.0 2.0 1 1 1 2 2 2 1 Protein tyrosine kinase WaaY PF06176.6 EPA04520.1 - 0.0032 16.6 2.1 0.0061 15.8 1.5 1.7 1 1 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) DUF1679 PF07914.6 EPA04520.1 - 0.0051 15.5 0.1 0.0081 14.8 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) Choline_kinase PF01633.15 EPA04520.1 - 0.078 12.5 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Rieske PF00355.21 EPA04522.1 - 2.4e-08 33.4 0.0 4e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_Fe-S_N PF10399.4 EPA04522.1 - 0.0016 17.5 0.0 0.0032 16.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal TAT_signal PF10518.4 EPA04522.1 - 0.0018 18.1 0.9 0.0018 18.1 0.6 1.9 2 0 0 2 2 2 1 TAT (twin-arginine translocation) pathway signal sequence AAA_18 PF13238.1 EPA04523.1 - 5.7e-15 55.7 0.6 5.7e-15 55.7 0.4 1.6 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EPA04523.1 - 1.2e-10 42.2 0.2 1.5e-10 41.9 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 EPA04523.1 - 0.00041 20.5 0.0 0.0012 19.0 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Cytidylate_kin2 PF13189.1 EPA04523.1 - 0.0019 18.1 0.1 0.019 14.9 0.1 2.1 1 1 0 1 1 1 1 Cytidylate kinase-like family KTI12 PF08433.5 EPA04523.1 - 0.0027 16.9 0.1 0.0065 15.7 0.0 1.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 NTPase_1 PF03266.10 EPA04523.1 - 0.0039 16.9 1.3 0.0085 15.8 0.1 2.1 2 2 0 2 2 2 1 NTPase Sulfotransfer_1 PF00685.22 EPA04523.1 - 0.024 13.8 0.0 0.025 13.8 0.0 1.1 1 0 0 1 1 1 0 Sulfotransferase domain CoaE PF01121.15 EPA04523.1 - 0.032 13.6 0.1 0.065 12.6 0.0 1.6 2 0 0 2 2 2 0 Dephospho-CoA kinase SKI PF01202.17 EPA04523.1 - 0.033 14.0 0.1 0.11 12.3 0.0 2.0 1 1 0 1 1 1 0 Shikimate kinase AAA_14 PF13173.1 EPA04523.1 - 0.042 13.7 0.2 0.068 13.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 EPA04523.1 - 0.059 12.5 0.2 0.12 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_5 PF07728.9 EPA04523.1 - 0.079 12.6 0.0 0.16 11.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EPA04523.1 - 0.089 12.7 0.0 0.13 12.1 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 EPA04523.1 - 0.1 12.7 0.0 0.28 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain Ham1p_like PF01725.11 EPA04524.1 - 9.7e-47 158.7 0.1 1.1e-46 158.5 0.1 1.0 1 0 0 1 1 1 1 Ham1 family Copper-bind PF00127.15 EPA04525.1 - 8.9e-10 38.6 0.0 1e-09 38.4 0.0 1.0 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 EPA04525.1 - 1.2e-05 25.1 0.0 1.8e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain DHHA1 PF02272.14 EPA04526.1 - 7.1e-09 35.2 0.7 1.6e-08 34.1 0.5 1.6 1 1 0 1 1 1 1 DHHA1 domain Arabinose_Iso_C PF11762.3 EPA04526.1 - 0.13 11.8 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 L-arabinose isomerase C-terminal domain MethyltransfD12 PF02086.10 EPA04528.1 - 1e-17 64.4 0.1 1.1e-17 64.3 0.1 1.0 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Cons_hypoth95 PF03602.10 EPA04528.1 - 0.028 13.8 0.7 0.076 12.4 0.1 1.8 1 1 1 2 2 2 0 Conserved hypothetical protein 95 RNA_binding PF01877.12 EPA04529.1 - 7.4e-25 87.2 3.8 8.7e-25 87.0 2.7 1.1 1 0 0 1 1 1 1 RNA binding ORF6N PF10543.4 EPA04529.1 - 0.094 12.7 3.5 0.2 11.7 1.8 2.1 1 1 1 2 2 2 0 ORF6N domain TSP_3 PF02412.13 EPA04530.1 - 6.3e-06 25.5 10.1 0.0014 18.0 0.1 3.9 4 0 0 4 4 4 2 Thrombospondin type 3 repeat P-II PF00543.17 EPA04532.1 - 5.7e-12 46.0 3.8 6.6e-12 45.7 2.6 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II TSP_3 PF02412.13 EPA04533.1 - 3.9e-16 58.2 46.5 0.00032 20.1 0.6 8.0 7 2 1 8 8 8 5 Thrombospondin type 3 repeat NOPS PF08075.6 EPA04533.1 - 0.13 12.7 9.1 6.8 7.1 0.0 4.7 6 1 1 7 7 7 0 NOPS (NUC059) domain Erv26 PF04148.8 EPA04534.1 - 0.02 14.2 0.0 0.022 14.1 0.0 1.1 1 0 0 1 1 1 0 Transmembrane adaptor Erv26 SH PF01445.12 EPA04534.1 - 0.047 13.3 0.3 0.088 12.4 0.2 1.4 1 0 0 1 1 1 0 Viral small hydrophobic protein EMP70 PF02990.11 EPA04534.1 - 0.11 10.9 0.0 0.12 10.8 0.0 1.0 1 0 0 1 1 1 0 Endomembrane protein 70 MF_alpha_N PF05436.6 EPA04534.1 - 0.12 12.0 0.1 0.18 11.5 0.1 1.2 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus SdpI PF13630.1 EPA04534.1 - 2 8.1 6.2 2.8 7.7 4.3 1.3 1 1 0 1 1 1 0 SdpI/YhfL protein family AsnC_trans_reg PF01037.16 EPA04535.1 - 8.5e-21 73.4 0.5 5.8e-10 38.7 0.0 2.2 2 0 0 2 2 2 2 AsnC family GYD PF08734.6 EPA04535.1 - 0.0006 19.4 0.0 1 9.1 0.0 2.2 2 0 0 2 2 2 2 GYD domain ACT_4 PF13291.1 EPA04535.1 - 0.039 14.2 1.5 48 4.3 0.0 3.8 3 1 1 4 4 4 0 ACT domain HMA PF00403.21 EPA04535.1 - 0.041 14.0 2.0 5.9 7.1 0.1 2.5 2 1 0 2 2 2 0 Heavy-metal-associated domain Herpes_BBRF1 PF04793.7 EPA04535.1 - 0.14 10.9 2.0 2.8 6.6 0.2 2.0 2 0 0 2 2 2 0 BRRF1-like protein DUF1296 PF06972.6 EPA04535.1 - 0.21 11.5 1.4 0.45 10.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) PALP PF00291.20 EPA04536.1 - 2.9e-21 75.9 0.0 2.8e-20 72.7 0.0 2.3 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CTP_transf_2 PF01467.21 EPA04537.1 - 1.9e-12 47.5 0.0 7.9e-12 45.5 0.0 1.8 1 1 0 1 1 1 1 Cytidylyltransferase FAD_syn PF06574.7 EPA04537.1 - 0.017 14.7 0.2 0.037 13.6 0.1 1.7 2 1 0 2 2 2 0 FAD synthetase HTH_IclR PF09339.5 EPA04538.1 - 2e-05 24.0 0.0 8.5e-05 22.0 0.0 1.9 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_24 PF13412.1 EPA04538.1 - 0.0001 21.5 0.0 0.001 18.3 0.0 2.5 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding B12-binding_2 PF02607.12 EPA04538.1 - 0.0002 21.3 0.0 0.00033 20.6 0.0 1.4 1 0 0 1 1 1 1 B12 binding domain HTH_23 PF13384.1 EPA04538.1 - 0.00097 18.7 0.0 0.0035 16.9 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 EPA04538.1 - 0.0012 18.8 0.0 0.0044 16.9 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_11 PF08279.7 EPA04538.1 - 0.0013 18.3 0.0 0.0028 17.2 0.0 1.6 1 0 0 1 1 1 1 HTH domain KorB PF08535.5 EPA04538.1 - 0.015 15.4 0.0 0.12 12.5 0.0 2.4 2 1 1 3 3 3 0 KorB domain HTH_29 PF13551.1 EPA04538.1 - 0.016 15.3 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix TrmB PF01978.14 EPA04538.1 - 0.018 14.7 0.0 0.19 11.4 0.0 2.4 2 1 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.17 EPA04538.1 - 0.019 14.6 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 MarR family Wzz PF02706.10 EPA04538.1 - 0.37 10.5 3.1 4.7 7.0 0.1 2.3 2 0 0 2 2 2 0 Chain length determinant protein NERD PF08378.6 EPA04539.1 - 0.0015 18.8 3.0 0.093 13.0 0.2 2.3 2 1 0 2 2 2 2 Nuclease-related domain Pcc1 PF09341.5 EPA04540.1 - 0.00082 19.3 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 Transcription factor Pcc1 Ribosomal_L12 PF00542.14 EPA04540.1 - 0.065 13.2 1.2 0.12 12.3 0.1 1.8 2 0 0 2 2 2 0 Ribosomal protein L7/L12 C-terminal domain Mor PF08765.6 EPA04540.1 - 0.13 12.0 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Mor transcription activator family MethyltransfD12 PF02086.10 EPA04541.1 - 3.8e-38 131.4 0.5 4.9e-38 131.0 0.3 1.0 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase DUF2089 PF09862.4 EPA04541.1 - 0.001 18.8 0.2 0.0031 17.2 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2089) TelA PF05816.6 EPA04541.1 - 0.098 11.3 0.3 0.14 10.8 0.2 1.1 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) Dus PF01207.12 EPA04542.1 - 2.1e-73 246.8 0.0 2.5e-73 246.6 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.16 EPA04542.1 - 4.2e-08 32.4 0.1 4.6e-06 25.8 0.0 2.2 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase Oxidored_FMN PF00724.15 EPA04542.1 - 1.6e-06 27.3 0.0 3.1e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family NanE PF04131.9 EPA04542.1 - 4.1e-05 22.6 0.1 0.00013 20.9 0.0 1.8 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.16 EPA04542.1 - 0.0034 16.6 0.0 0.0054 16.0 0.0 1.3 1 0 0 1 1 1 1 Histidine biosynthesis protein IMPDH PF00478.20 EPA04542.1 - 0.0034 16.3 0.0 0.0048 15.8 0.0 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain PcrB PF01884.12 EPA04542.1 - 0.056 12.6 0.0 0.099 11.8 0.0 1.4 1 0 0 1 1 1 0 PcrB family FMN_dh PF01070.13 EPA04542.1 - 0.069 11.9 0.1 0.13 11.0 0.0 1.5 2 0 0 2 2 2 0 FMN-dependent dehydrogenase VPS11_C PF12451.3 EPA04542.1 - 5.5 6.9 6.4 36 4.3 0.3 3.1 3 0 0 3 3 3 0 Vacuolar protein sorting protein 11 C terminal Archaeal_AmoA PF12942.2 EPA04544.1 - 4.7e-89 297.0 6.6 5.4e-89 296.8 4.6 1.0 1 0 0 1 1 1 1 Archaeal ammonia monooxygenase subunit A (AmoA) zf-C3HC4 PF00097.20 EPA04545.1 - 7.9 6.2 9.2 5 6.8 1.0 3.3 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) HTH_10 PF04967.7 EPA04546.1 - 0.049 13.2 0.0 0.05 13.1 0.0 1.2 1 0 0 1 1 1 0 HTH DNA binding domain HTH_Tnp_4 PF13613.1 EPA04546.1 - 0.051 13.1 0.0 0.082 12.4 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease DsbD PF02683.10 EPA04547.1 - 9.9e-45 152.7 22.1 1.2e-44 152.4 15.3 1.0 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region DsbD_2 PF13386.1 EPA04547.1 - 4.4e-08 33.1 16.5 6.7e-08 32.5 11.5 1.2 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region DUF2910 PF11139.3 EPA04547.1 - 0.0008 18.6 10.4 0.093 11.8 5.2 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF2910) Baculo_11_kDa PF06143.6 EPA04547.1 - 0.46 9.8 0.0 0.46 9.8 0.0 2.7 4 0 0 4 4 4 0 Baculovirus 11 kDa family AAA_5 PF07728.9 EPA04548.1 - 1e-23 83.6 0.1 1.4e-23 83.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EPA04548.1 - 4.9e-13 48.8 0.0 6.8e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 EPA04548.1 - 7.2e-08 32.7 0.0 1.2e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 EPA04548.1 - 1.8e-06 27.8 0.1 3e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 EPA04548.1 - 3.8e-06 26.4 0.0 6.7e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Arch_ATPase PF01637.13 EPA04548.1 - 1.5e-05 24.8 0.1 2.3e-05 24.2 0.1 1.4 1 0 0 1 1 1 1 Archaeal ATPase RuvB_N PF05496.7 EPA04548.1 - 5e-05 22.4 0.1 0.0016 17.5 0.0 2.5 1 1 1 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 EPA04548.1 - 0.00026 21.0 0.0 0.00045 20.2 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 EPA04548.1 - 0.00046 20.9 0.0 0.00088 20.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EPA04548.1 - 0.00087 19.4 0.0 0.0018 18.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.1 EPA04548.1 - 0.0011 19.0 0.0 0.008 16.2 0.0 2.2 1 1 1 2 2 2 1 Sigma-54 interaction domain Miro PF08477.8 EPA04548.1 - 0.0014 19.0 0.0 0.003 18.0 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein Mg_chelatase PF01078.16 EPA04548.1 - 0.0021 17.2 0.0 0.33 10.0 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 EPA04548.1 - 0.0059 16.2 0.0 0.068 12.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 EPA04548.1 - 0.0085 16.0 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EPA04548.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.9 EPA04548.1 - 0.013 15.4 0.5 0.038 13.8 0.3 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF258 PF03193.11 EPA04548.1 - 0.014 14.6 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 CbbQ_C PF08406.5 EPA04548.1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 CbbQ/NirQ/NorQ C-terminal MobB PF03205.9 EPA04548.1 - 0.016 14.8 0.0 0.034 13.8 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B KAP_NTPase PF07693.9 EPA04548.1 - 0.04 12.9 0.0 0.045 12.7 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain RNA12 PF10443.4 EPA04548.1 - 0.049 12.1 0.0 0.078 11.4 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein UPF0079 PF02367.12 EPA04548.1 - 0.061 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 DUF815 PF05673.8 EPA04548.1 - 0.063 12.2 0.0 0.27 10.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ABC_tran PF00005.22 EPA04548.1 - 0.07 13.4 0.1 0.14 12.4 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA_11 PF13086.1 EPA04548.1 - 0.07 12.6 0.0 0.095 12.2 0.0 1.3 1 1 0 1 1 1 0 AAA domain cobW PF02492.14 EPA04548.1 - 0.08 12.3 0.1 0.15 11.5 0.1 1.5 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.1 EPA04548.1 - 0.087 12.3 0.0 0.22 11.0 0.0 1.8 2 1 0 2 2 1 0 AAA domain T2SE PF00437.15 EPA04548.1 - 0.098 11.5 0.0 0.25 10.2 0.0 1.6 1 1 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.7 EPA04548.1 - 0.098 12.3 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.1 EPA04548.1 - 0.17 12.1 1.1 0.28 11.4 0.8 1.6 1 1 0 1 1 1 0 AAA domain tRNA-synt_2b PF00587.20 EPA04549.1 - 7.5e-36 123.3 0.1 1.3e-35 122.4 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 EPA04549.1 - 5.5e-24 84.2 11.2 1.2e-23 83.1 7.7 1.6 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain FimP PF09766.4 EPA04549.1 - 0.016 14.2 3.4 0.035 13.1 2.3 1.5 1 0 0 1 1 1 0 Fms-interacting protein TMPIT PF07851.8 EPA04549.1 - 0.23 10.5 3.8 0.46 9.5 2.6 1.4 1 0 0 1 1 1 0 TMPIT-like protein BLOC1_2 PF10046.4 EPA04549.1 - 0.82 9.8 8.8 0.2 11.8 3.1 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Wzt_C PF14524.1 EPA04550.1 - 0.0045 16.6 0.0 0.016 14.9 0.0 1.9 2 0 0 2 2 2 1 Wzt C-terminal domain OapA PF04225.7 EPA04550.1 - 0.043 13.6 0.1 0.14 12.0 0.0 1.9 1 1 0 1 1 1 0 Opacity-associated protein A LysM-like domain FAD_binding_2 PF00890.19 EPA04551.1 - 1.1e-06 27.8 1.8 0.018 13.9 0.0 2.2 1 1 1 2 2 2 2 FAD binding domain FAD_oxidored PF12831.2 EPA04551.1 - 3.1e-05 23.2 0.0 5.6e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.19 EPA04551.1 - 8.1e-05 21.6 0.9 0.28 10.0 0.2 2.4 1 1 0 2 2 2 2 FAD dependent oxidoreductase Trp_halogenase PF04820.9 EPA04551.1 - 0.00023 19.9 0.0 0.0064 15.1 0.0 2.7 3 0 0 3 3 3 1 Tryptophan halogenase Thi4 PF01946.12 EPA04551.1 - 0.00032 19.8 1.5 0.0049 16.0 1.0 2.3 1 1 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.7 EPA04551.1 - 0.00065 18.7 0.0 0.0011 18.0 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.14 EPA04551.1 - 0.001 18.2 0.2 0.068 12.2 0.0 2.4 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 EPA04551.1 - 0.0017 18.2 0.8 0.012 15.4 0.5 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EPA04551.1 - 0.032 14.2 0.2 0.11 12.5 0.1 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EPA04551.1 - 0.062 11.7 0.0 0.11 10.9 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Ribosomal_S13_N PF08069.7 EPA04552.1 - 1.9e-26 91.6 0.1 3.4e-26 90.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.17 EPA04552.1 - 4.4e-17 61.6 0.4 7.8e-17 60.8 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 Nnf1 PF03980.9 EPA04552.1 - 0.01 15.8 0.2 0.018 15.0 0.1 1.4 1 0 0 1 1 1 1 Nnf1 HDA2-3 PF11496.3 EPA04552.1 - 0.085 11.6 0.4 0.62 8.8 0.2 1.9 1 1 1 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 TBP PF00352.16 EPA04553.1 - 1.9e-61 203.4 0.1 6.1e-31 105.6 0.0 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 EPA04553.1 - 0.00012 22.0 0.0 0.096 12.7 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF217 PF02697.9 EPA04554.1 - 0.054 13.7 0.9 1.1 9.5 0.6 2.1 1 1 0 1 1 1 0 Uncharacterized ACR, COG1753 ASCH PF04266.9 EPA04555.1 - 2.7e-10 40.5 0.0 3.5e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 ASCH domain zinc_ribbon_6 PF14599.1 EPA04556.1 - 0.038 13.7 3.5 0.12 12.1 2.4 1.8 1 1 0 1 1 1 0 Zinc-ribbon C1_1 PF00130.17 EPA04556.1 - 0.13 12.0 2.7 0.22 11.2 1.9 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Na_trans_assoc PF06512.8 EPA04556.1 - 0.22 11.4 6.3 0.26 11.2 4.3 1.0 1 0 0 1 1 1 0 Sodium ion transport-associated DNA_RNApol_7kD PF03604.8 EPA04556.1 - 0.32 10.4 3.8 1.4 8.4 2.6 2.0 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Eapp_C PF10238.4 EPA04556.1 - 2.6 7.9 9.5 0.67 9.8 3.0 2.1 1 1 0 2 2 2 0 E2F-associated phosphoprotein Bax1-I PF01027.15 EPA04557.1 - 0.0052 16.4 4.4 0.0054 16.3 3.1 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 YesK PF14150.1 EPA04557.1 - 0.085 12.9 0.4 0.085 12.9 0.3 1.7 2 0 0 2 2 2 0 YesK-like protein FixP_N PF14715.1 EPA04557.1 - 2 7.8 7.0 13 5.2 1.8 2.4 1 1 1 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP ETRAMP PF09716.5 EPA04557.1 - 2.8 7.9 4.8 1.7 8.6 0.1 2.5 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Monooxygenase_B PF04744.7 EPA04558.1 - 6.1e-07 28.4 0.1 1.5e-06 27.2 0.0 1.6 2 0 0 2 2 2 1 Monooxygenase subunit B protein VWA PF00092.23 EPA04559.1 - 3.6e-09 36.6 0.1 2.5e-08 33.8 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.1 EPA04559.1 - 1.7e-08 34.7 0.0 2.4e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 EPA04559.1 - 0.012 15.3 0.0 0.058 13.2 0.0 2.1 2 1 0 2 2 2 0 vWA found in TerF C terminus Redoxin PF08534.5 EPA04561.1 - 1.3e-09 37.7 0.0 2.3e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 EPA04561.1 - 7.7e-08 32.0 0.1 1.3e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.1 EPA04561.1 - 0.00025 21.1 0.2 0.00055 19.9 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin-like AsnC_trans_reg PF01037.16 EPA04562.1 - 4e-13 48.8 0.1 4.7e-13 48.6 0.1 1.0 1 0 0 1 1 1 1 AsnC family DUF1469 PF07332.6 EPA04563.1 - 0.031 13.9 3.6 0.13 11.9 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) DUF3997 PF13162.1 EPA04564.1 - 0.025 14.3 1.2 0.034 13.9 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3997) AhpC-TSA PF00578.16 EPA04565.1 - 8.4e-21 73.9 0.4 1.1e-20 73.6 0.3 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EPA04565.1 - 4.6e-12 45.7 0.1 5.8e-12 45.3 0.1 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.1 EPA04565.1 - 1.9e-08 34.2 0.7 3.5e-08 33.4 0.5 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 EPA04565.1 - 1.7e-07 31.4 0.2 2.5e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain T4_deiodinase PF00837.12 EPA04565.1 - 0.0038 16.2 0.0 0.041 12.8 0.0 1.9 1 1 1 2 2 2 1 Iodothyronine deiodinase Thioredoxin_3 PF13192.1 EPA04565.1 - 0.0076 16.0 0.5 0.26 11.1 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin domain Thioredoxin PF00085.15 EPA04565.1 - 0.032 13.9 0.2 0.69 9.6 0.0 2.2 1 1 1 2 2 2 0 Thioredoxin TSP_3 PF02412.13 EPA04568.1 - 1.9e-11 43.2 31.6 0.00016 21.0 1.5 5.2 6 0 0 6 6 6 3 Thrombospondin type 3 repeat DUF282 PF03380.9 EPA04568.1 - 0.11 12.2 0.8 2 8.2 0.1 2.6 2 0 0 2 2 2 0 Caenorhabditis protein of unknown function, DUF282 A2M_N PF01835.14 EPA04570.1 - 0.0059 16.8 0.1 0.015 15.4 0.0 1.7 1 0 0 1 1 1 1 MG2 domain I-set PF07679.11 EPA04570.1 - 0.02 14.7 0.1 0.04 13.7 0.1 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain Methylase_S PF01420.14 EPA04570.1 - 0.051 13.5 0.7 0.051 13.5 0.5 2.2 2 1 0 2 2 2 0 Type I restriction modification DNA specificity domain Ribosomal_S3Ae PF01015.13 EPA04571.1 - 1.3e-64 217.1 5.6 1.4e-64 216.9 3.9 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family DUF4468 PF14730.1 EPA04571.1 - 0.056 13.1 0.2 0.18 11.5 0.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold Band_7 PF01145.20 EPA04571.1 - 0.091 12.6 0.5 0.49 10.2 0.3 2.1 1 1 0 1 1 1 0 SPFH domain / Band 7 family DHH PF01368.15 EPA04572.1 - 2.9e-09 36.7 0.2 4.4e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 DHH family AmoC PF04896.7 EPA04573.1 - 2.4e-15 56.2 4.6 3e-15 55.9 3.2 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C zf-AN1 PF01428.11 EPA04575.1 - 9.1e-12 44.6 2.0 1.1e-11 44.3 1.4 1.1 1 0 0 1 1 1 1 AN1-like Zinc finger Pyr_redox_2 PF07992.9 EPA04576.1 - 2.8e-17 63.2 0.0 4.7e-17 62.5 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EPA04576.1 - 0.00024 21.4 2.8 0.22 11.9 0.0 3.7 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EPA04576.1 - 0.00077 19.4 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EPA04576.1 - 0.0013 18.5 0.0 0.02 14.6 0.0 2.5 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 EPA04576.1 - 0.016 14.0 0.0 0.65 8.7 0.0 2.6 3 0 0 3 3 3 0 FAD binding domain Trp_halogenase PF04820.9 EPA04576.1 - 0.033 12.8 0.0 0.047 12.3 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase DAO PF01266.19 EPA04576.1 - 0.11 11.3 0.0 0.25 10.1 0.0 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase tRNA_NucTransf2 PF09249.6 EPA04577.1 - 1.7e-39 134.1 0.1 3.8e-39 133.0 0.0 1.6 1 0 0 1 1 1 1 tRNA nucleotidyltransferase, second domain NTP_transf_2 PF01909.18 EPA04577.1 - 5.2e-08 33.1 0.2 1.5e-07 31.6 0.2 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain CLN6 PF15156.1 EPA04579.1 - 0.0091 15.1 0.4 0.01 14.9 0.3 1.1 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 6 B12D PF06522.6 EPA04579.1 - 0.046 13.4 0.4 0.1 12.3 0.0 1.8 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit EmrE PF13536.1 EPA04579.1 - 0.096 12.8 4.1 0.13 12.4 2.9 1.3 1 0 0 1 1 1 0 Multidrug resistance efflux transporter LigT_PEase PF02834.11 EPA04581.1 - 3.5e-23 81.3 0.0 1.9e-12 46.9 0.0 2.1 2 0 0 2 2 2 2 LigT like Phosphoesterase AKAP7_NLS PF10469.4 EPA04581.1 - 3.5e-14 53.0 0.1 4.6e-14 52.6 0.1 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.1 EPA04581.1 - 2.4e-09 37.0 0.0 2.9e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily AAA_18 PF13238.1 EPA04583.1 - 1.8e-13 50.8 0.1 2.1e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EPA04583.1 - 1.1e-11 45.5 0.0 1.4e-11 45.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EPA04583.1 - 0.00011 22.1 0.0 0.0002 21.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.10 EPA04583.1 - 0.00013 21.7 0.5 0.16 11.6 0.1 2.1 1 1 1 2 2 2 2 NTPase AAA_22 PF13401.1 EPA04583.1 - 0.00031 20.9 0.1 0.00045 20.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain ArgK PF03308.11 EPA04583.1 - 0.00071 18.4 0.1 0.00098 17.9 0.0 1.3 1 0 0 1 1 1 1 ArgK protein AAA_28 PF13521.1 EPA04583.1 - 0.0014 18.5 0.0 0.0017 18.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain ADK PF00406.17 EPA04583.1 - 0.0017 18.2 0.1 0.002 17.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase CoaE PF01121.15 EPA04583.1 - 0.0028 17.0 0.0 0.0049 16.2 0.0 1.4 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_14 PF13173.1 EPA04583.1 - 0.0035 17.2 0.0 0.005 16.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 EPA04583.1 - 0.0036 16.5 0.1 0.0081 15.3 0.0 1.7 1 1 1 2 2 2 1 Chromatin associated protein KTI12 APS_kinase PF01583.15 EPA04583.1 - 0.004 16.8 0.1 0.013 15.1 0.0 1.8 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_29 PF13555.1 EPA04583.1 - 0.006 16.0 0.3 0.011 15.2 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.24 EPA04583.1 - 0.012 15.8 0.2 0.02 15.1 0.1 1.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 EPA04583.1 - 0.012 14.6 0.1 0.037 13.1 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin NB-ARC PF00931.17 EPA04583.1 - 0.015 14.1 0.0 0.015 14.1 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain Hpr_kinase_C PF07475.7 EPA04583.1 - 0.024 13.9 0.0 0.045 13.0 0.0 1.4 1 1 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_16 PF13191.1 EPA04583.1 - 0.048 13.6 0.0 0.052 13.5 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.1 EPA04583.1 - 0.062 13.6 0.6 0.085 13.1 0.4 1.6 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 EPA04583.1 - 0.081 12.4 0.0 0.092 12.2 0.0 1.3 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.9 EPA04583.1 - 0.087 12.5 0.1 0.33 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 EPA04583.1 - 0.1 12.3 0.4 0.21 11.3 0.2 1.5 1 0 0 1 1 1 0 Part of AAA domain MMR_HSR1 PF01926.18 EPA04583.1 - 0.12 12.2 0.2 0.17 11.8 0.2 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.22 EPA04583.1 - 0.14 12.4 0.5 0.18 12.1 0.4 1.3 1 1 0 1 1 1 0 ABC transporter adh_short PF00106.20 EPA04584.1 - 1.3e-35 122.7 0.1 2.3e-35 121.9 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 EPA04584.1 - 1e-20 74.5 1.3 1.3e-20 74.2 0.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EPA04584.1 - 1.5e-13 50.8 0.0 2.5e-13 50.0 0.0 1.3 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EPA04584.1 - 0.00011 22.2 1.4 0.00061 19.8 1.0 2.0 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EPA04584.1 - 0.00016 21.1 0.1 0.025 14.0 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family DUF1776 PF08643.5 EPA04584.1 - 0.0019 17.3 0.0 0.0026 16.9 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.3 EPA04584.1 - 0.0077 16.0 3.2 0.01 15.5 1.2 1.9 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.14 EPA04584.1 - 0.021 13.9 2.9 0.33 10.0 0.0 2.6 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain BRCT PF00533.21 EPA04584.1 - 0.096 12.8 0.1 0.25 11.5 0.1 2.0 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Pkinase PF00069.20 EPA04585.1 - 3.5e-05 23.0 0.5 5.8e-05 22.3 0.2 1.5 1 1 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 EPA04585.1 - 0.0001 21.7 0.0 0.00018 20.9 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.15 EPA04585.1 - 0.00026 20.6 0.1 0.051 13.1 0.0 2.9 3 1 0 4 4 4 2 Choline/ethanolamine kinase DUF3083 PF11281.3 EPA04586.1 - 0.06 12.4 0.8 0.083 12.0 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3083) Staygreen PF12638.2 EPA04586.1 - 0.066 12.7 0.0 0.088 12.3 0.0 1.2 1 0 0 1 1 1 0 Staygreen protein Fcf2 PF08698.6 EPA04586.1 - 0.07 13.1 0.5 0.12 12.4 0.3 1.3 1 0 0 1 1 1 0 Fcf2 pre-rRNA processing Peptidase_A3 PF02160.10 EPA04586.1 - 0.073 12.6 3.2 0.16 11.5 0.6 2.2 1 1 1 2 2 2 0 Cauliflower mosaic virus peptidase (A3) Rhabdo_M1 PF03342.8 EPA04586.1 - 0.074 12.1 1.2 0.11 11.6 0.8 1.4 1 1 0 1 1 1 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) Pterin_4a PF01329.14 EPA04587.1 - 2.5e-33 113.6 0.2 2.7e-33 113.6 0.2 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase IF-2 PF11987.3 EPA04587.1 - 0.0045 16.8 0.1 0.011 15.6 0.1 1.6 1 1 1 2 2 2 1 Translation-initiation factor 2 DUF327 PF03885.8 EPA04588.1 - 0.014 15.2 0.5 0.014 15.2 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF327) DUF1825 PF08855.5 EPA04588.1 - 0.048 13.6 3.8 0.14 12.1 0.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1825) ATC_hydrolase PF14196.1 EPA04588.1 - 0.25 11.7 4.7 3.2 8.1 0.1 3.1 1 1 2 3 3 3 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase Usp PF00582.21 EPA04588.1 - 0.31 11.2 2.9 0.29 11.3 0.1 2.2 2 0 0 2 2 2 0 Universal stress protein family SurA_N_2 PF13623.1 EPA04588.1 - 0.33 10.9 3.6 0.51 10.3 0.2 2.8 3 0 0 3 3 3 0 SurA N-terminal domain DUF4398 PF14346.1 EPA04588.1 - 1.2 9.1 5.1 4.6 7.3 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4398) HEPN PF05168.9 EPA04588.1 - 1.7 8.5 5.5 1 9.2 0.1 3.0 2 2 1 3 3 3 0 HEPN domain Lyase_1 PF00206.15 EPA04589.1 - 9.2e-50 169.5 1.3 1.4e-49 168.9 0.9 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.4 EPA04589.1 - 2.9e-19 68.8 0.0 7.9e-19 67.4 0.0 1.8 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus PTPS PF01242.14 EPA04590.1 - 2.8e-10 39.9 0.0 3.3e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase VP4_haemagglut PF00426.13 EPA04590.1 - 0.058 11.3 0.1 0.066 11.1 0.0 1.1 1 0 0 1 1 1 0 Outer Capsid protein VP4 (Hemagglutinin) DUF2567 PF10821.3 EPA04591.1 - 0.021 14.3 0.0 0.11 11.9 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2567) Herpes_U26 PF07402.6 EPA04592.1 - 0.099 11.9 1.6 0.11 11.7 1.1 1.0 1 0 0 1 1 1 0 Human herpesvirus U26 protein DUF788 PF05620.6 EPA04592.1 - 0.12 12.2 0.4 0.12 12.2 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF788) AIRS PF00586.19 EPA04594.1 - 1.5e-11 44.3 0.0 3.3e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain AIRS_C PF02769.17 EPA04594.1 - 1.3e-06 28.5 0.0 1.8e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain TTKRSYEDQ PF10212.4 EPA04594.1 - 0.12 11.2 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein PGM_PMM_I PF02878.11 EPA04595.1 - 5.6e-24 84.1 0.0 1.7e-23 82.6 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 EPA04595.1 - 2.9e-15 56.2 0.1 1.5e-14 53.9 0.0 2.1 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 EPA04595.1 - 2.1e-13 50.4 0.0 4.9e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 EPA04595.1 - 2.6e-07 30.5 0.2 8.6e-07 28.8 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Latrotoxin_C PF15658.1 EPA04595.1 - 0.027 14.2 1.8 0.063 13.1 0.6 2.1 2 0 0 2 2 2 0 Latrotoxin C-terminal domain AAA_10 PF12846.2 EPA04595.1 - 0.035 13.5 0.0 0.25 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain Ribosomal_S11 PF00411.14 EPA04596.1 - 8.1e-38 128.9 0.7 1e-37 128.6 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 DUF4247 PF14042.1 EPA04596.1 - 0.077 12.9 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4247) Pox_polyA_pol_C PF12629.2 EPA04597.1 - 0.11 12.2 0.6 1.4 8.6 0.0 2.5 1 1 1 2 2 2 0 Poxvirus poly(A) polymerase C-terminal domain HJURP_C PF12347.3 EPA04598.1 - 0.11 12.0 0.1 0.17 11.4 0.1 1.4 1 1 0 1 1 1 0 Holliday junction regulator protein family C-terminal repeat EF-1_beta_acid PF10587.4 EPA04599.1 - 0.003 17.6 1.6 0.0054 16.8 1.1 1.4 1 0 0 1 1 1 1 Eukaryotic elongation factor 1 beta central acidic region dsDNA_bind PF01984.15 EPA04599.1 - 0.0049 16.8 0.5 0.006 16.5 0.3 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain tRNA-synt_1 PF00133.17 EPA04600.1 - 1.1e-108 363.8 0.7 7.6e-108 361.0 0.5 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 EPA04600.1 - 1.5e-31 109.1 2.7 1.5e-31 109.1 1.9 1.8 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 EPA04600.1 - 3e-25 88.6 4.1 5.9e-13 48.2 0.0 3.5 2 2 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 EPA04600.1 - 0.00018 20.8 1.2 0.068 12.4 0.0 3.2 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 DUF531 PF04407.7 EPA04600.1 - 0.1 12.5 0.2 0.85 9.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF531) Asn_synthase PF00733.16 EPA04602.1 - 6.9e-31 107.6 0.0 1.5e-30 106.5 0.0 1.5 1 1 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.12 EPA04602.1 - 4.8e-07 28.9 0.4 2.3e-06 26.7 0.1 2.0 2 0 0 2 2 2 1 NAD synthase QueC PF06508.8 EPA04602.1 - 0.00011 21.5 0.1 0.0003 20.1 0.1 1.7 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC DUF2683 PF10884.3 EPA04602.1 - 0.055 13.4 0.2 0.15 12.0 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2683) ATP_bind_3 PF01171.15 EPA04602.1 - 0.15 11.5 0.6 0.74 9.2 0.2 2.3 2 1 0 2 2 2 0 PP-loop family Apolipoprotein PF01442.13 EPA04603.1 - 0.00087 18.8 3.4 0.0015 18.1 2.4 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF342 PF03961.8 EPA04603.1 - 2 6.7 12.2 3.5 5.9 8.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF342) DUF2852 PF11014.3 EPA04603.1 - 2.9 7.8 5.0 5.2 7.0 3.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) DUF87 PF01935.12 EPA04603.1 - 7.6 6.2 10.4 5.8 6.6 5.2 1.9 1 1 1 2 2 2 0 Domain of unknown function DUF87 RtcB PF01139.12 EPA04605.1 - 2.4e-152 507.8 0.1 2.7e-152 507.6 0.1 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB DUF3492 PF11997.3 EPA04605.1 - 0.057 12.9 0.1 0.091 12.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Complex1_LYR PF05347.10 EPA04605.1 - 0.057 13.2 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 Complex 1 protein (LYR family) FIBP PF05427.6 EPA04605.1 - 0.063 12.4 0.0 0.097 11.8 0.0 1.2 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) GATase PF00117.23 EPA04606.1 - 8.4e-35 119.9 0.0 9.4e-35 119.8 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EPA04606.1 - 1e-06 28.4 0.1 1.6e-05 24.4 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 SNO PF01174.14 EPA04606.1 - 0.0001 21.9 0.0 0.00092 18.8 0.0 1.9 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 EPA04606.1 - 0.00011 21.8 0.0 0.00027 20.5 0.0 1.6 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain IGPD PF00475.13 EPA04607.1 - 4.1e-29 101.3 0.0 4.6e-29 101.1 0.0 1.0 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase ANF_receptor PF01094.23 EPA04607.1 - 0.029 13.1 0.0 0.035 12.8 0.0 1.1 1 0 0 1 1 1 0 Receptor family ligand binding region His_biosynth PF00977.16 EPA04608.1 - 7.3e-39 133.3 0.2 8e-39 133.2 0.1 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Mitovir_RNA_pol PF05919.6 EPA04608.1 - 0.08 11.8 0.0 0.083 11.8 0.0 1.1 1 0 0 1 1 1 0 Mitovirus RNA-dependent RNA polymerase RAI16-like PF10257.4 EPA04609.1 - 0.024 13.5 0.3 0.16 10.8 0.1 1.9 1 1 1 2 2 2 0 Retinoic acid induced 16-like protein AKAP95 PF04988.7 EPA04609.1 - 0.07 12.9 1.7 0.086 12.6 1.0 1.3 1 1 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) PH PF00169.24 EPA04609.1 - 0.28 11.4 2.5 0.4 10.9 1.7 1.6 1 1 0 1 1 1 0 PH domain zf-DNA_Pol PF08996.5 EPA04610.1 - 0.0034 16.7 1.1 0.0034 16.7 0.8 1.1 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger zinc_ribbon_4 PF13717.1 EPA04610.1 - 0.023 14.3 0.3 0.48 10.1 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 EPA04610.1 - 0.023 14.2 0.2 0.44 10.1 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-PHD-like PF15446.1 EPA04610.1 - 0.14 11.4 1.8 0.47 9.7 0.1 1.9 1 1 1 2 2 2 0 PHD/FYVE-zinc-finger like domain C1_4 PF07975.7 EPA04610.1 - 0.17 11.8 4.6 0.36 10.8 3.2 1.6 1 1 0 1 1 1 0 TFIIH C1-like domain zf-AN1 PF01428.11 EPA04610.1 - 0.53 10.2 7.4 1.7 8.6 1.5 2.4 2 1 0 2 2 2 0 AN1-like Zinc finger PHD_2 PF13831.1 EPA04610.1 - 0.67 9.3 4.0 1.1 8.6 0.3 2.3 2 0 0 2 2 2 0 PHD-finger HNH PF01844.18 EPA04610.1 - 4.4 7.2 6.6 1.2 9.0 0.9 2.2 2 0 0 2 2 2 0 HNH endonuclease DUF4355 PF14265.1 EPA04613.1 - 0.0031 17.4 4.1 0.0042 17.0 2.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4355) Cep57_MT_bd PF06657.8 EPA04615.1 - 0.00034 20.5 3.7 0.00034 20.5 2.5 1.7 1 1 1 2 2 2 1 Centrosome microtubule-binding domain of Cep57 FCH PF00611.18 EPA04615.1 - 0.005 16.9 2.8 0.0054 16.8 1.4 1.4 1 1 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain DUF2130 PF09903.4 EPA04615.1 - 0.0077 15.0 7.6 0.0086 14.8 5.3 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2130) Flagellar_rod PF05149.7 EPA04615.1 - 0.03 13.5 3.3 0.036 13.2 2.3 1.0 1 0 0 1 1 1 0 Paraflagellar rod protein MRP-L46 PF11788.3 EPA04615.1 - 0.05 14.2 3.5 0.059 14.0 2.4 1.1 1 0 0 1 1 1 0 39S mitochondrial ribosomal protein L46 Glyco_hydro_26 PF02156.10 EPA04615.1 - 0.061 12.7 0.2 0.065 12.6 0.1 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 26 CR6_interact PF10147.4 EPA04615.1 - 0.07 12.4 4.6 0.085 12.1 3.2 1.1 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Tho2 PF11262.3 EPA04615.1 - 0.072 12.1 7.1 0.083 11.9 4.9 1.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Mig-14 PF07395.6 EPA04615.1 - 0.079 11.9 1.0 0.084 11.8 0.7 1.0 1 0 0 1 1 1 0 Mig-14 TBCA PF02970.11 EPA04615.1 - 0.08 13.0 4.3 0.1 12.6 3.0 1.2 1 0 0 1 1 1 0 Tubulin binding cofactor A APG6 PF04111.7 EPA04615.1 - 0.097 11.6 3.5 0.11 11.4 2.4 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 HAUS6_N PF14661.1 EPA04615.1 - 0.1 11.9 1.9 0.11 11.7 1.3 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Uds1 PF15456.1 EPA04615.1 - 0.82 9.6 5.7 4.4 7.3 4.0 1.8 1 1 0 1 1 1 0 Up-regulated During Septation V-SNARE PF05008.10 EPA04615.1 - 1.1 9.4 8.5 3.4 7.9 0.3 2.2 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus TMPIT PF07851.8 EPA04615.1 - 1.5 7.8 4.6 1.7 7.6 3.2 1.0 1 0 0 1 1 1 0 TMPIT-like protein ELK PF03789.8 EPA04615.1 - 2.6 7.9 0.0 2.6 7.9 0.0 2.9 3 1 0 3 3 3 0 ELK domain Fe-ADH PF00465.14 EPA04616.1 - 7e-51 172.9 0.0 2.4e-50 171.1 0.0 1.7 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.1 EPA04616.1 - 3.6e-19 69.0 0.0 5e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.15 EPA04616.1 - 0.0027 16.6 0.0 0.17 10.8 0.0 2.4 2 0 0 2 2 2 2 3-dehydroquinate synthase ABC_sub_bind PF04392.7 EPA04616.1 - 0.12 11.3 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 ABC transporter substrate binding protein Pyridox_ox_2 PF12900.2 EPA04617.1 - 6.3e-23 81.1 0.0 7.1e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxidase PF01243.15 EPA04617.1 - 1.2e-16 60.4 0.0 2.2e-16 59.6 0.0 1.4 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase FMN_bind_2 PF04299.7 EPA04617.1 - 0.0071 15.8 0.0 0.0098 15.3 0.0 1.2 1 0 0 1 1 1 1 Putative FMN-binding domain DUF4147 PF13660.1 EPA04618.1 - 1e-71 240.8 0.0 1.4e-71 240.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) MOFRL PF05161.8 EPA04618.1 - 6.8e-17 61.5 2.4 9.2e-17 61.1 0.8 1.9 2 0 0 2 2 2 1 MOFRL family Bac_luciferase PF00296.15 EPA04619.1 - 5.6e-55 186.6 0.0 7e-55 186.3 0.0 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase RNA_pol_Rpc34 PF05158.7 EPA04620.1 - 0.021 14.0 0.6 0.021 14.0 0.4 1.5 2 0 0 2 2 2 0 RNA polymerase Rpc34 subunit Hepatitis_core PF00906.15 EPA04620.1 - 1.1 8.8 5.2 1.7 8.2 3.6 1.2 1 0 0 1 1 1 0 Hepatitis core antigen LOH1CR12 PF10158.4 EPA04621.1 - 0.06 13.1 2.6 0.072 12.8 1.4 1.5 1 1 1 2 2 2 0 Tumour suppressor protein FliS PF02561.9 EPA04621.1 - 0.15 11.9 1.6 0.18 11.6 1.1 1.1 1 0 0 1 1 1 0 Flagellar protein FliS SNARE_assoc PF09335.6 EPA04622.1 - 1.3e-21 77.0 1.9 1.6e-21 76.8 0.8 1.5 1 1 1 2 2 2 1 SNARE associated Golgi protein ATP-synt_F6 PF05511.6 EPA04623.1 - 0.0023 17.8 0.2 0.0081 16.0 0.2 2.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase coupling factor 6 MRP-S23 PF10484.4 EPA04623.1 - 0.4 10.5 5.1 0.086 12.7 0.4 2.2 3 1 0 3 3 3 0 Mitochondrial ribosomal protein S23 GLTSCR1 PF15249.1 EPA04623.1 - 0.41 10.7 3.5 5.1 7.2 2.4 2.4 1 1 0 1 1 1 0 Glioma tumor suppressor candidate region DUF4441 PF14536.1 EPA04624.1 - 0.76 9.7 8.1 1.4 8.8 5.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4441) PALP PF00291.20 EPA04626.1 - 1.3e-42 146.1 0.0 1.7e-42 145.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PK_C PF02887.11 EPA04626.1 - 0.34 10.4 1.7 0.88 9.1 0.3 2.1 2 0 0 2 2 2 0 Pyruvate kinase, alpha/beta domain Hjc PF01870.13 EPA04627.1 - 0.00022 20.7 0.0 0.00033 20.1 0.0 1.3 1 0 0 1 1 1 1 Archaeal holliday junction resolvase (hjc) AsnC_trans_reg PF01037.16 EPA04628.1 - 0.0017 18.0 0.6 0.0021 17.7 0.4 1.2 1 0 0 1 1 1 1 AsnC family HALZ PF02183.13 EPA04629.1 - 0.0068 16.1 6.2 0.013 15.2 4.3 1.4 1 0 0 1 1 1 1 Homeobox associated leucine zipper DivIC PF04977.10 EPA04629.1 - 0.026 14.0 0.4 0.05 13.0 0.2 1.5 1 0 0 1 1 1 0 Septum formation initiator Mod_r PF07200.8 EPA04629.1 - 0.3 10.9 6.3 0.24 11.3 2.8 1.9 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF1516 PF07457.6 EPA04630.1 - 0.029 14.4 1.0 0.029 14.4 0.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1516) DUF4418 PF14387.1 EPA04630.1 - 0.097 12.4 1.4 0.19 11.4 1.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4418) TarH PF02203.10 EPA04630.1 - 0.12 12.1 0.4 0.21 11.4 0.3 1.3 1 0 0 1 1 1 0 Tar ligand binding domain homologue DUF2085 PF09858.4 EPA04630.1 - 0.41 10.7 4.0 0.11 12.6 0.6 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2085) Sdh_cyt PF01127.17 EPA04630.1 - 3 7.6 5.5 6.1 6.7 0.8 2.0 2 0 0 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit zf-PARP PF00645.13 EPA04632.1 - 0.073 13.3 1.6 0.087 13.0 1.1 1.0 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Cytochrom_c3_2 PF14537.1 EPA04632.1 - 0.083 13.2 1.1 0.1 12.9 0.8 1.1 1 0 0 1 1 1 0 Cytochrome c3 CHASE4 PF05228.8 EPA04633.1 - 0.11 12.0 0.9 0.11 12.0 0.6 1.0 1 0 0 1 1 1 0 CHASE4 domain Ribonuc_red_2_N PF08471.5 EPA04633.1 - 0.12 12.5 0.1 0.12 12.5 0.1 1.1 1 0 0 1 1 1 0 Class II vitamin B12-dependent ribonucleotide reductase DUF357 PF04010.8 EPA04634.1 - 0.092 12.4 0.1 0.12 12.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF357) Thiolase_C PF02803.13 EPA04635.1 - 1.1e-12 47.4 1.2 2.1e-12 46.5 0.2 1.9 2 1 1 3 3 3 1 Thiolase, C-terminal domain Thiolase_N PF00108.18 EPA04635.1 - 1.9e-05 23.8 0.1 4.4e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain Dodecin PF07311.7 EPA04635.1 - 0.00071 19.5 0.3 0.0016 18.4 0.2 1.5 1 0 0 1 1 1 1 Dodecin ketoacyl-synt PF00109.21 EPA04635.1 - 0.0011 18.5 0.0 0.0026 17.2 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 EPA04635.1 - 0.0019 17.8 0.0 0.0056 16.3 0.0 1.8 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ketoacyl-synt_C PF02801.17 EPA04635.1 - 0.0028 17.4 0.4 0.93 9.3 0.1 2.5 2 0 0 2 2 2 2 Beta-ketoacyl synthase, C-terminal domain Guanylate_cyc PF00211.15 EPA04636.1 - 7.6e-18 64.5 0.0 1.1e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF3244 PF11589.3 EPA04637.1 - 0.0046 16.6 0.1 0.0046 16.6 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3244) DapB_N PF01113.15 EPA04638.1 - 2.4e-05 24.2 0.0 4.2e-05 23.4 0.0 1.4 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Gp_dh_N PF00044.19 EPA04638.1 - 0.00021 21.2 0.0 0.0032 17.4 0.0 2.0 1 1 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.19 EPA04638.1 - 0.00058 20.1 0.0 0.00065 19.9 0.0 1.1 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_3 PF03447.11 EPA04638.1 - 0.003 17.9 0.0 0.004 17.5 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 EPA04638.1 - 0.073 13.0 0.0 0.4 10.6 0.0 1.9 2 0 0 2 2 2 0 NADH(P)-binding IlvN PF07991.7 EPA04638.1 - 0.14 11.4 0.0 0.26 10.6 0.0 1.4 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain CbiK PF06180.6 EPA04639.1 - 0.032 13.3 0.0 0.13 11.2 0.0 1.7 1 1 1 2 2 2 0 Cobalt chelatase (CbiK) Methyltransf_18 PF12847.2 EPA04639.1 - 0.051 14.1 0.0 0.14 12.7 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain AIRC PF00731.15 EPA04640.1 - 1.8e-57 192.8 0.2 2.6e-57 192.3 0.1 1.2 1 0 0 1 1 1 1 AIR carboxylase DUF719 PF05334.8 EPA04640.1 - 0.034 14.1 0.1 0.054 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF719) NTP_transferase PF00483.18 EPA04641.1 - 7.8e-32 110.5 0.3 1.1e-31 110.0 0.2 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 EPA04641.1 - 5.9e-12 45.9 0.0 8e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.14 EPA04641.1 - 0.00083 18.9 0.0 0.003 17.1 0.0 1.9 1 1 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Bgal_small_N PF02929.12 EPA04641.1 - 0.0038 16.2 0.2 0.0053 15.8 0.1 1.1 1 0 0 1 1 1 1 Beta galactosidase small chain LpxK PF02606.9 EPA04641.1 - 0.065 12.1 0.0 0.36 9.7 0.0 1.8 2 0 0 2 2 2 0 Tetraacyldisaccharide-1-P 4'-kinase DUF21 PF01595.15 EPA04644.1 - 1.9e-53 180.4 1.3 2.6e-53 180.0 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF21 CorC_HlyC PF03471.12 EPA04644.1 - 1.3e-17 63.3 0.5 1.3e-17 63.3 0.3 1.7 2 0 0 2 2 2 1 Transporter associated domain CBS PF00571.23 EPA04644.1 - 4.1e-16 58.4 0.2 1.2e-06 28.1 0.0 2.7 2 0 0 2 2 2 2 CBS domain Glyco_tranf_2_3 PF13641.1 EPA04646.1 - 2.3e-38 132.2 0.0 3.2e-38 131.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 EPA04646.1 - 9.3e-36 123.0 0.1 1.9e-35 122.0 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.1 EPA04646.1 - 3.8e-24 85.4 0.0 3.8e-24 85.4 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Chitin_synth_2 PF03142.10 EPA04646.1 - 9.1e-13 47.4 0.6 5.5e-09 34.9 0.0 3.3 2 1 1 3 3 3 2 Chitin synthase Glyco_tranf_2_2 PF10111.4 EPA04646.1 - 1.4e-12 47.3 0.2 3.3e-12 46.0 0.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EPA04646.1 - 3.2e-11 42.8 0.0 5.6e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.1 EPA04646.1 - 0.0048 17.1 0.0 0.014 15.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 2 DUF4519 PF15012.1 EPA04646.1 - 0.086 12.7 1.4 0.19 11.6 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) DUF912 PF06024.7 EPA04646.1 - 0.13 12.3 5.1 0.1 12.6 0.4 2.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) CarboxypepD_reg PF13620.1 EPA04646.1 - 0.15 12.1 0.9 56 3.8 0.0 3.8 3 1 0 3 3 3 0 Carboxypeptidase regulatory-like domain DZR PF12773.2 EPA04647.1 - 0.049 13.4 4.8 0.15 11.9 3.3 1.7 1 1 0 1 1 1 0 Double zinc ribbon LIM PF00412.17 EPA04647.1 - 0.11 12.5 8.3 0.14 12.2 5.7 1.1 1 0 0 1 1 1 0 LIM domain Yippee-Mis18 PF03226.9 EPA04647.1 - 0.13 12.3 3.0 0.16 12.0 2.1 1.3 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly ZZ PF00569.12 EPA04647.1 - 0.16 11.5 6.6 0.19 11.3 4.6 1.1 1 0 0 1 1 1 0 Zinc finger, ZZ type DUF4428 PF14471.1 EPA04647.1 - 0.25 11.1 2.4 0.26 11.0 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) Pox_A3L PF05288.6 EPA04647.1 - 0.45 10.2 4.1 1.3 8.8 0.0 2.0 1 1 1 2 2 2 0 Poxvirus A3L Protein FYVE PF01363.16 EPA04647.1 - 0.58 10.0 4.2 0.71 9.8 2.9 1.1 1 0 0 1 1 1 0 FYVE zinc finger IBR PF01485.16 EPA04647.1 - 1 9.2 6.9 5.6 6.9 4.8 1.9 1 1 0 1 1 1 0 IBR domain zinc-ribbons_6 PF07191.7 EPA04647.1 - 1.5 8.6 6.6 13 5.6 4.6 1.9 1 1 0 1 1 1 0 zinc-ribbons zf-HIT PF04438.11 EPA04647.1 - 5.6 6.6 7.1 11 5.7 4.8 1.7 1 1 0 1 1 1 0 HIT zinc finger DUF35_N PF12172.3 EPA04648.1 - 0.00039 20.2 0.0 0.00071 19.4 0.0 1.4 1 0 0 1 1 1 1 Rubredoxin-like zinc ribbon domain (DUF35_N) DZR PF12773.2 EPA04648.1 - 0.049 13.4 1.3 0.086 12.6 0.9 1.5 1 0 0 1 1 1 0 Double zinc ribbon Cript PF10235.4 EPA04648.1 - 0.33 11.3 1.7 0.39 11.0 0.9 1.5 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT Bac_luciferase PF00296.15 EPA04649.1 - 3.2e-51 174.2 0.0 3.9e-51 174.0 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase PPDK_N PF01326.14 EPA04649.1 - 0.014 14.4 0.0 0.13 11.3 0.0 1.9 2 0 0 2 2 2 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain DUF4649 PF15507.1 EPA04649.1 - 0.026 14.3 0.0 0.32 10.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4649) AsnC_trans_reg PF01037.16 EPA04651.1 - 5.9e-07 29.1 0.0 7.1e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 AsnC family DUF2730 PF10805.3 EPA04651.1 - 0.006 16.3 0.0 0.0069 16.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2730) ACT_4 PF13291.1 EPA04651.1 - 0.029 14.7 0.4 0.15 12.4 0.2 1.9 1 1 1 2 2 2 0 ACT domain PALP PF00291.20 EPA04652.1 - 4.2e-78 262.6 0.8 7.1e-78 261.9 0.5 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACT PF01842.20 EPA04652.1 - 0.00013 21.3 0.1 0.00034 20.0 0.1 1.7 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.1 EPA04652.1 - 0.00015 22.0 0.3 0.00042 20.5 0.2 1.7 1 0 0 1 1 1 1 ACT domain Thr_dehydrat_C PF00585.13 EPA04652.1 - 0.0027 17.2 0.1 0.025 14.1 0.0 2.3 3 0 0 3 3 3 1 C-terminal regulatory domain of Threonine dehydratase Peripla_BP_4 PF13407.1 EPA04652.1 - 0.023 14.0 0.3 3.8 6.7 0.1 2.5 2 1 0 2 2 2 0 Periplasmic binding protein domain Glyoxalase_2 PF12681.2 EPA04653.1 - 5.1e-15 55.9 0.0 6.4e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 EPA04653.1 - 4.4e-08 33.1 0.0 1e-07 31.9 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 EPA04653.1 - 0.0027 17.6 0.0 0.16 11.9 0.0 2.2 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CBFB_NFYA PF02045.10 EPA04654.1 - 0.055 14.0 0.0 0.079 13.5 0.0 1.3 1 0 0 1 1 1 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B ATP-grasp PF02222.17 EPA04655.1 - 5.4e-58 195.1 0.0 8.3e-58 194.5 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.1 EPA04655.1 - 2e-17 63.5 0.0 3.1e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EPA04655.1 - 6e-08 32.3 0.0 1.5e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.1 EPA04655.1 - 7.4e-06 24.9 0.0 0.00015 20.6 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 EPA04655.1 - 7.7e-05 22.6 0.2 0.00018 21.3 0.1 1.7 1 1 0 1 1 1 1 ATP-grasp domain RimK PF08443.6 EPA04655.1 - 0.00044 19.7 0.2 0.0016 17.9 0.1 1.8 1 1 0 1 1 1 1 RimK-like ATP-grasp domain 2-Hacid_dh_C PF02826.14 EPA04655.1 - 0.0021 17.2 0.0 0.0041 16.2 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1297 PF06973.7 EPA04655.1 - 0.0076 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) TrkA_N PF02254.13 EPA04655.1 - 0.02 14.9 0.2 0.21 11.5 0.0 2.6 3 0 0 3 3 3 0 TrkA-N domain Pyr_redox PF00070.22 EPA04655.1 - 0.14 12.6 0.4 1.7 9.1 0.0 2.9 3 1 1 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase Abhydrolase_6 PF12697.2 EPA04655.1 - 0.21 11.4 0.0 0.28 11.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Sec5 PF15469.1 EPA04656.1 - 0.008 15.9 0.8 0.026 14.2 0.6 1.8 1 1 0 1 1 1 1 Exocyst complex component Sec5 IFT20 PF14931.1 EPA04656.1 - 0.02 14.7 1.6 0.72 9.7 0.1 2.1 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 MCPsignal PF00015.16 EPA04656.1 - 0.048 13.1 0.7 0.059 12.8 0.5 1.1 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF2894 PF11445.3 EPA04656.1 - 0.13 12.5 0.2 0.14 12.4 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) Peptidase_S8 PF00082.17 EPA04657.1 - 1.3e-15 57.3 1.2 2.1e-15 56.6 0.0 1.9 2 0 0 2 2 2 1 Subtilase family DUF1034 PF06280.7 EPA04657.1 - 7e-05 23.2 2.9 0.0014 19.0 0.0 3.0 3 0 0 3 3 3 1 Fn3-like domain (DUF1034) Peptidase_S8 PF00082.17 EPA04658.1 - 1.7e-14 53.6 0.1 4.6e-14 52.2 0.0 1.8 2 0 0 2 2 2 1 Subtilase family DUF1034 PF06280.7 EPA04658.1 - 1e-05 25.8 0.3 0.00047 20.5 0.0 2.6 2 0 0 2 2 2 1 Fn3-like domain (DUF1034) DUF916 PF06030.7 EPA04658.1 - 0.0019 17.9 0.3 6.2 6.6 0.0 3.6 3 0 0 3 3 3 2 Bacterial protein of unknown function (DUF916) FixG_C PF11614.3 EPA04658.1 - 0.02 14.9 0.1 0.19 11.8 0.0 2.3 2 0 0 2 2 2 0 IG-like fold at C-terminal of FixG, putative oxidoreductase DUF1297 PF06973.7 EPA04659.1 - 5.2e-12 45.4 0.1 5.3e-12 45.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) DUF2387 PF09526.5 EPA04660.1 - 0.0014 18.5 0.5 0.0017 18.2 0.4 1.2 1 0 0 1 1 1 1 Probable metal-binding protein (DUF2387) zf-FPG_IleRS PF06827.9 EPA04660.1 - 0.0062 16.1 1.5 0.2 11.3 0.1 2.3 2 0 0 2 2 2 1 Zinc finger found in FPG and IleRS DUF3268 PF11672.3 EPA04660.1 - 0.021 14.8 0.1 0.022 14.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3268) Lar_restr_allev PF14354.1 EPA04660.1 - 0.054 13.8 0.1 0.066 13.5 0.1 1.2 1 0 0 1 1 1 0 Restriction alleviation protein Lar DZR PF12773.2 EPA04660.1 - 0.079 12.7 1.3 0.18 11.6 0.9 1.6 1 1 0 1 1 1 0 Double zinc ribbon Elf1 PF05129.8 EPA04660.1 - 0.15 11.7 0.5 0.19 11.4 0.3 1.1 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Cys_rich_KTR PF14205.1 EPA04660.1 - 0.29 10.6 3.2 0.63 9.5 2.2 1.6 1 1 0 1 1 1 0 Cysteine-rich KTR A2L_zn_ribbon PF08792.5 EPA04661.1 - 1.5 8.3 5.0 0.57 9.7 0.8 2.2 1 1 1 2 2 2 0 A2L zinc ribbon domain HhH-GPD PF00730.20 EPA04662.1 - 1.9e-23 82.7 0.1 2.6e-23 82.3 0.1 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 EPA04662.1 - 1.1e-08 34.3 0.0 3.5e-08 32.6 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif DUF2400 PF09674.5 EPA04662.1 - 0.0011 18.7 0.2 0.0047 16.6 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2400) HHH_5 PF14520.1 EPA04662.1 - 0.0042 17.2 0.3 0.033 14.3 0.2 2.1 1 1 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.2 EPA04662.1 - 0.025 14.4 0.0 2.7 7.9 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.4 EPA04662.1 - 0.28 11.4 3.8 0.49 10.6 2.7 1.4 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III HhH-GPD PF00730.20 EPA04663.1 - 1.2e-23 83.4 0.1 1.6e-23 83.0 0.1 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 EPA04663.1 - 1.5e-08 33.8 0.0 3.5e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif DUF2400 PF09674.5 EPA04663.1 - 0.0012 18.6 0.2 0.0057 16.3 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2400) HHH_5 PF14520.1 EPA04663.1 - 0.0015 18.6 0.3 0.013 15.6 0.2 2.1 1 1 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.2 EPA04663.1 - 0.013 15.4 0.0 2.7 7.9 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif DUF4028 PF13220.1 EPA04663.1 - 0.062 12.9 0.2 0.15 11.7 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4028) EndIII_4Fe-2S PF10576.4 EPA04663.1 - 0.26 11.5 3.6 0.45 10.7 2.5 1.4 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III Copper-bind PF00127.15 EPA04664.1 - 8.1e-18 64.4 2.1 3e-09 37.0 0.1 2.5 2 0 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 EPA04664.1 - 2.4e-14 53.0 0.0 5.4e-06 26.2 0.0 2.6 2 0 0 2 2 2 2 Cupredoxin-like domain Trypan_PARP PF05887.6 EPA04664.1 - 0.061 13.1 23.2 0.17 11.6 12.5 2.9 3 0 0 3 3 3 0 Procyclic acidic repetitive protein (PARP) PLRV_ORF5 PF01690.12 EPA04664.1 - 9.6 5.2 21.3 19 4.2 14.7 1.5 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein DUF3040 PF11239.3 EPA04665.1 - 0.026 14.5 0.4 0.25 11.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) DUF872 PF05915.7 EPA04665.1 - 0.12 12.2 0.2 0.53 10.1 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) DUF202 PF02656.10 EPA04665.1 - 0.14 12.4 0.1 1.5 9.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF202) SdpI PF13630.1 EPA04665.1 - 1.9 8.2 7.5 2.6 7.8 2.1 2.4 2 0 0 2 2 2 0 SdpI/YhfL protein family YtpI PF14007.1 EPA04665.1 - 2.7 7.9 7.6 0.38 10.6 1.2 2.2 2 0 0 2 2 2 0 YtpI-like protein tRNA_anti-codon PF01336.20 EPA04666.1 - 3.2e-06 26.9 0.2 4.1e-06 26.5 0.1 1.2 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain HupF_HypC PF01455.13 EPA04666.1 - 0.051 13.5 0.9 2.3 8.2 0.5 2.1 1 1 1 2 2 2 0 HupF/HypC family CBS PF00571.23 EPA04667.1 - 1.9e-53 177.9 11.2 2.2e-14 52.9 0.1 4.1 4 0 0 4 4 4 4 CBS domain Peptidase_S55 PF05580.7 EPA04667.1 - 0.0091 15.4 0.1 0.0091 15.4 0.1 1.9 2 1 0 2 2 2 1 SpoIVB peptidase S55 PduV-EutP PF10662.4 EPA04667.1 - 0.035 13.5 9.2 1.5 8.2 0.4 3.8 2 1 1 4 4 4 0 Ethanolamine utilisation - propanediol utilisation DUF3641 PF12345.3 EPA04667.1 - 0.092 12.5 0.0 2.2 8.1 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3641) MgtC PF02308.11 EPA04668.1 - 3.1e-36 124.1 7.4 3.6e-36 123.9 5.1 1.1 1 0 0 1 1 1 1 MgtC family PCMT PF01135.14 EPA04670.1 - 5.6e-58 195.9 0.0 7e-58 195.6 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 EPA04670.1 - 7.9e-10 38.5 0.0 1.2e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 EPA04670.1 - 2.4e-08 33.3 0.0 3.4e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_18 PF12847.2 EPA04670.1 - 4.1e-08 33.7 0.0 6.5e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EPA04670.1 - 0.00019 21.4 0.0 0.0003 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EPA04670.1 - 0.00022 20.6 0.0 0.00043 19.6 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase small domain GCD14 PF08704.5 EPA04670.1 - 0.00025 20.6 0.0 0.00037 20.0 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_11 PF08241.7 EPA04670.1 - 0.00075 19.9 0.0 0.0011 19.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EPA04670.1 - 0.0013 17.8 0.0 0.0019 17.2 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase DOT1 PF08123.8 EPA04670.1 - 0.0014 18.0 0.0 0.0025 17.1 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 CMAS PF02353.15 EPA04670.1 - 0.0025 16.9 0.0 0.0036 16.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase GidB PF02527.10 EPA04670.1 - 0.0053 15.9 0.1 0.0095 15.0 0.0 1.5 2 0 0 2 2 2 1 rRNA small subunit methyltransferase G Methyltransf_25 PF13649.1 EPA04670.1 - 0.0097 16.2 0.0 0.015 15.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA04670.1 - 0.032 13.9 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Fibrillarin PF01269.12 EPA04670.1 - 0.036 12.9 0.0 0.059 12.2 0.0 1.3 1 0 0 1 1 1 0 Fibrillarin Ubie_methyltran PF01209.13 EPA04670.1 - 0.04 13.0 0.0 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.1 EPA04670.1 - 0.079 12.6 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.7 EPA04670.1 - 0.095 12.2 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) zf-C3HC4 PF00097.20 EPA04671.1 - 0.0093 15.6 3.2 0.012 15.2 2.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FlpD PF02662.11 EPA04672.1 - 0.0098 15.5 0.8 0.016 14.8 0.3 1.5 1 1 1 2 2 2 1 Methyl-viologen-reducing hydrogenase, delta subunit Syntaxin_2 PF14523.1 EPA04672.1 - 0.017 15.1 1.3 0.018 15.0 0.9 1.1 1 0 0 1 1 1 0 Syntaxin-like protein MRP-S26 PF14943.1 EPA04672.1 - 0.051 13.1 3.5 0.052 13.1 2.4 1.0 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Syntaxin PF00804.20 EPA04672.1 - 0.058 13.5 2.7 0.065 13.3 1.9 1.3 1 1 0 1 1 1 0 Syntaxin DUF2963 PF11178.3 EPA04672.1 - 0.078 12.4 1.1 0.078 12.4 0.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2963) Pox_TAA1 PF03295.9 EPA04672.1 - 0.5 10.0 2.1 0.97 9.1 0.1 2.0 2 0 0 2 2 2 0 Poxvirus trans-activator protein A1 C-terminal Radical_SAM PF04055.16 EPA04673.1 - 9.1e-10 38.9 1.5 1e-09 38.7 0.1 1.8 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.1 EPA04673.1 - 0.073 13.1 1.5 0.089 12.9 0.1 1.8 2 0 0 2 2 2 0 4Fe-4S single cluster domain zf-CHCC PF10276.4 EPA04673.1 - 3 7.7 6.9 1.1 9.1 0.5 3.0 2 0 0 2 2 2 0 Zinc-finger domain Cpn60_TCP1 PF00118.19 EPA04674.1 - 6.2e-162 539.5 16.9 7.1e-162 539.3 11.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3924 PF13062.1 EPA04674.1 - 0.0094 15.7 0.0 0.045 13.6 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3924) AdoMet_Synthase PF01941.14 EPA04675.1 - 9.4e-144 478.7 1.2 1.1e-143 478.5 0.8 1.0 1 0 0 1 1 1 1 S-adenosylmethionine synthetase (AdoMet synthetase) Zn-ribbon_8 PF09723.5 EPA04676.1 - 0.017 15.0 1.0 0.03 14.2 0.7 1.4 1 1 0 1 1 1 0 Zinc ribbon domain Rtf2 PF04641.7 EPA04676.1 - 0.02 14.0 0.3 0.021 14.0 0.2 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger zf-C2HC5 PF06221.8 EPA04676.1 - 0.028 14.1 0.9 0.029 14.1 0.6 1.1 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type DUF2072 PF09845.4 EPA04676.1 - 0.028 14.3 0.1 0.028 14.3 0.1 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) zf-TFIIB PF13453.1 EPA04676.1 - 0.042 13.0 0.7 0.043 13.0 0.0 1.5 2 0 0 2 2 2 0 Transcription factor zinc-finger TF_Zn_Ribbon PF08271.7 EPA04676.1 - 0.043 13.1 0.8 3.6 6.9 0.1 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding HypA PF01155.14 EPA04676.1 - 0.047 13.3 0.2 0.047 13.3 0.1 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family A2L_zn_ribbon PF08792.5 EPA04676.1 - 0.14 11.6 0.7 6.3 6.3 0.1 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain Rubredoxin PF00301.15 EPA04676.1 - 0.15 11.9 0.5 7 6.6 0.0 2.1 2 0 0 2 2 2 0 Rubredoxin UPF0547 PF10571.4 EPA04676.1 - 0.17 11.5 2.3 3.3 7.5 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-RING_3 PF14369.1 EPA04676.1 - 0.74 9.8 2.9 2.2 8.3 2.0 1.9 1 1 0 1 1 1 0 zinc-finger Ycf66_N PF07444.6 EPA04677.1 - 0.18 11.5 1.4 0.19 11.4 1.0 1.2 1 0 0 1 1 1 0 Ycf66 protein N-terminus DUF131 PF01998.12 EPA04678.1 - 0.58 9.5 3.4 0.87 8.9 2.4 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF131 AAA_33 PF13671.1 EPA04679.1 - 2.3e-12 47.0 0.2 3.2e-12 46.5 0.1 1.3 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 EPA04679.1 - 0.00043 19.5 0.4 0.00045 19.5 0.3 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 ParA PF10609.4 EPA04679.1 - 0.0085 15.9 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 ParA/MinD ATPase like Pterin_bind PF00809.17 EPA04679.1 - 0.013 14.8 0.0 0.016 14.5 0.0 1.1 1 0 0 1 1 1 0 Pterin binding enzyme Guanylate_kin PF00625.16 EPA04679.1 - 0.047 13.1 0.3 0.059 12.8 0.2 1.1 1 0 0 1 1 1 0 Guanylate kinase Peptidase_M29 PF02073.10 EPA04679.1 - 0.083 11.6 0.1 0.099 11.3 0.1 1.0 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) SHOCT PF09851.4 EPA04680.1 - 5.7e-12 44.6 1.2 9.2e-12 44.0 0.9 1.4 1 0 0 1 1 1 1 Short C-terminal domain GvpG PF05120.7 EPA04680.1 - 0.015 15.0 0.6 0.03 14.1 0.1 1.6 1 1 1 2 2 2 0 Gas vesicle protein G TraX PF05857.6 EPA04680.1 - 0.019 14.6 0.1 0.022 14.4 0.1 1.1 1 0 0 1 1 1 0 TraX protein Halogen_Hydrol PF10112.4 EPA04680.1 - 0.11 11.9 0.1 0.12 11.7 0.1 1.1 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Sod_Fe_C PF02777.13 EPA04681.1 - 8.8e-37 125.1 1.6 1.4e-36 124.5 1.1 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 EPA04681.1 - 2.1e-25 88.7 0.1 4.9e-25 87.5 0.1 1.7 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain BPD_transp_1 PF00528.17 EPA04682.1 - 4.7e-27 94.6 9.1 4.7e-27 94.6 6.3 2.3 3 0 0 3 3 3 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.2 EPA04682.1 - 0.00055 19.2 1.7 0.0013 18.0 0.3 2.2 2 0 0 2 2 2 1 N-terminal TM domain of oligopeptide transport permease C TBP PF00352.16 EPA04683.1 - 8.7e-61 201.2 0.0 1e-29 101.6 0.0 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 EPA04683.1 - 1.8e-06 27.9 0.0 0.0069 16.4 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) SNF2_N PF00176.18 EPA04684.1 - 2.9e-39 134.6 0.1 4.1e-39 134.1 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EPA04684.1 - 2.6e-09 36.8 0.0 7e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EPA04684.1 - 7.1e-08 32.4 2.5 9.1e-08 32.1 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EPA04684.1 - 9e-08 31.7 0.0 3.1e-07 30.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase FlgD_ig PF13860.1 EPA04685.1 - 0.082 12.6 0.9 1.9 8.3 0.1 2.6 3 0 0 3 3 3 0 FlgD Ig-like domain BPD_transp_1 PF00528.17 EPA04686.1 - 6.5e-37 126.8 18.2 6.5e-37 126.8 12.6 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component HN PF00423.14 EPA04686.1 - 0.12 10.6 2.0 0.15 10.2 1.4 1.2 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase Ndc1_Nup PF09531.5 EPA04686.1 - 0.13 10.6 4.8 0.29 9.4 3.3 1.5 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAD-oxidase_C PF02913.14 EPA04687.1 - 2.7e-41 141.5 0.0 3.5e-41 141.1 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 EPA04687.1 - 7.5e-33 112.9 0.0 1.3e-32 112.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EPA04687.1 - 0.012 15.5 0.0 0.033 14.0 0.0 1.8 1 0 0 1 1 1 0 Berberine and berberine like HTH_24 PF13412.1 EPA04688.1 - 0.022 14.1 0.4 0.071 12.5 0.2 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_5 PF01022.15 EPA04688.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Lectin_C PF00059.16 EPA04689.1 - 0.23 12.0 1.8 0.71 10.5 1.3 1.8 1 1 0 1 1 1 0 Lectin C-type domain GDPD_2 PF13653.1 EPA04690.1 - 0.077 13.2 0.5 6.3 7.1 0.0 2.2 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family NDUF_B8 PF05821.6 EPA04690.1 - 0.12 12.0 0.2 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Snapin_Pallidin PF14712.1 EPA04691.1 - 0.052 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Snapin/Pallidin DEAD_2 PF06733.10 EPA04691.1 - 0.066 12.6 1.6 0.092 12.1 0.7 1.6 1 1 0 1 1 1 0 DEAD_2 HSP20 PF00011.16 EPA04692.1 - 4.9e-23 80.9 2.3 6.7e-23 80.5 1.6 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family CS PF04969.11 EPA04692.1 - 0.00023 21.6 1.8 0.00057 20.3 1.2 1.7 1 1 0 1 1 1 1 CS domain PID PF00640.18 EPA04692.1 - 0.26 11.2 1.4 0.85 9.5 0.1 2.0 1 1 1 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) Prim_Zn_Ribbon PF08273.7 EPA04693.1 - 0.045 13.8 3.1 0.14 12.2 0.6 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Lar_restr_allev PF14354.1 EPA04693.1 - 0.046 14.0 5.0 0.06 13.6 3.4 1.2 1 0 0 1 1 1 0 Restriction alleviation protein Lar DUF4428 PF14471.1 EPA04693.1 - 0.49 10.1 5.2 0.88 9.3 3.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4428) zf-ISL3 PF14690.1 EPA04693.1 - 1.6 8.8 5.5 0.57 10.2 0.7 2.2 1 1 1 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Zn-ribbon_8 PF09723.5 EPA04693.1 - 2.3 8.2 6.1 6.8 6.7 0.4 2.3 1 1 1 2 2 2 0 Zinc ribbon domain HTH_5 PF01022.15 EPA04694.1 - 0.0026 17.3 2.1 0.0073 15.9 0.5 2.5 2 1 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_27 PF13463.1 EPA04694.1 - 0.0071 16.6 0.2 0.027 14.8 0.0 2.1 2 1 0 2 2 2 1 Winged helix DNA-binding domain TrmB PF01978.14 EPA04694.1 - 0.024 14.3 2.3 0.24 11.1 0.1 3.0 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.2 EPA04694.1 - 0.024 14.4 0.1 0.24 11.2 0.0 2.2 1 1 1 2 2 2 0 Helix-turn-helix domain HTH_34 PF13601.1 EPA04694.1 - 0.034 14.1 0.2 0.094 12.7 0.2 1.7 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_Crp_2 PF13545.1 EPA04694.1 - 0.11 12.3 0.2 3.3 7.5 0.0 2.4 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_24 PF13412.1 EPA04694.1 - 0.19 11.1 2.8 1.3 8.4 0.2 3.0 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding DUF4423 PF14394.1 EPA04694.1 - 0.22 11.0 5.7 1.6 8.2 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4423) HTH_11 PF08279.7 EPA04694.1 - 0.31 10.7 3.2 0.41 10.3 0.2 2.6 3 0 0 3 3 3 0 HTH domain OsmC PF02566.14 EPA04695.1 - 2.9e-17 62.6 0.0 5.3e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 OsmC-like protein zf-NADH-PPase PF09297.6 EPA04696.1 - 0.00019 20.8 2.7 0.0084 15.5 0.5 2.1 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain Peptidase_C74 PF12387.3 EPA04696.1 - 0.0098 15.0 1.3 0.01 15.0 0.9 1.0 1 0 0 1 1 1 1 Pestivirus NS2 peptidase zinc-ribbons_6 PF07191.7 EPA04696.1 - 0.017 14.8 0.2 0.018 14.7 0.1 1.1 1 0 0 1 1 1 0 zinc-ribbons TF_Zn_Ribbon PF08271.7 EPA04696.1 - 0.024 13.9 2.0 0.23 10.8 0.0 2.0 2 0 0 2 2 2 0 TFIIB zinc-binding zf-C3HC4_3 PF13920.1 EPA04696.1 - 0.027 14.1 1.4 0.031 13.9 1.0 1.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DNA_ligase_ZBD PF03119.11 EPA04696.1 - 0.031 13.9 1.1 0.29 10.8 0.0 2.1 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain zf-C4_Topoisom PF01396.14 EPA04696.1 - 0.04 13.4 0.1 0.04 13.4 0.1 1.7 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Zn-ribbon_8 PF09723.5 EPA04696.1 - 0.054 13.4 3.8 0.47 10.4 2.6 2.0 1 1 0 1 1 1 0 Zinc ribbon domain TFIIS_C PF01096.13 EPA04696.1 - 0.069 12.7 3.2 4.2 7.0 0.1 2.1 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Zn_ribbon_recom PF13408.1 EPA04696.1 - 0.078 13.2 5.5 0.45 10.8 1.0 2.0 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain Laminin_EGF PF00053.19 EPA04696.1 - 0.093 12.6 2.2 0.094 12.6 1.5 1.1 1 0 0 1 1 1 0 Laminin EGF-like (Domains III and V) Copper-fist PF00649.13 EPA04696.1 - 0.096 11.8 1.8 0.11 11.7 1.3 1.1 1 0 0 1 1 1 0 Copper fist DNA binding domain zf-FPG_IleRS PF06827.9 EPA04696.1 - 0.1 12.2 1.8 0.85 9.3 0.1 2.1 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Opy2 PF09463.5 EPA04696.1 - 0.11 12.6 1.9 0.13 12.3 1.3 1.1 1 0 0 1 1 1 0 Opy2 protein DUF1272 PF06906.6 EPA04696.1 - 0.14 11.9 1.8 0.18 11.6 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) Zn_Tnp_IS1595 PF12760.2 EPA04696.1 - 0.15 11.8 4.2 0.52 10.1 0.7 2.0 1 1 1 2 2 2 0 Transposase zinc-ribbon domain DUF2296 PF10058.4 EPA04696.1 - 0.21 11.3 1.9 1.2 8.9 0.1 2.0 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) zf-ISL3 PF14690.1 EPA04696.1 - 0.21 11.6 0.9 0.21 11.6 0.6 1.8 1 1 1 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-HIT PF04438.11 EPA04696.1 - 0.29 10.8 5.5 0.61 9.7 3.8 1.6 1 1 0 1 1 1 0 HIT zinc finger Ogr_Delta PF04606.7 EPA04696.1 - 0.36 10.5 0.5 0.36 10.5 0.4 1.7 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger OrfB_Zn_ribbon PF07282.6 EPA04696.1 - 0.5 10.0 3.1 1.2 8.8 2.2 1.6 1 1 0 1 1 1 0 Putative transposase DNA-binding domain zf-IS66 PF13005.2 EPA04696.1 - 0.74 9.8 3.0 0.47 10.4 0.3 1.8 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 zf-ribbon_3 PF13248.1 EPA04696.1 - 1 8.6 5.1 0.26 10.5 0.5 1.9 1 1 1 2 2 1 0 zinc-ribbon domain Cys_rich_KTR PF14205.1 EPA04696.1 - 1.3 8.5 3.4 6 6.3 0.2 2.0 2 0 0 2 2 2 0 Cysteine-rich KTR Rubredoxin PF00301.15 EPA04696.1 - 2.5 8.0 5.2 8.5 6.3 0.3 2.1 1 1 1 2 2 2 0 Rubredoxin DUF3290 PF11694.3 EPA04697.1 - 0.096 12.4 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) ArsC PF03960.10 EPA04699.1 - 4.5e-22 78.2 1.9 5.3e-22 77.9 1.3 1.0 1 0 0 1 1 1 1 ArsC family Glutaredoxin PF00462.19 EPA04699.1 - 0.00013 21.8 2.0 0.052 13.5 0.2 2.1 1 1 1 2 2 2 2 Glutaredoxin Thioredoxin_4 PF13462.1 EPA04699.1 - 0.035 14.0 0.6 0.26 11.3 0.0 2.0 1 1 1 2 2 2 0 Thioredoxin CarboxypepD_reg PF13620.1 EPA04700.1 - 1.6e-08 34.4 1.6 2.7e-08 33.7 1.1 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF4480 PF13715.1 EPA04700.1 - 2e-07 30.9 3.5 3.6e-07 30.1 2.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4480) Big_1 PF02369.11 EPA04700.1 - 6.2e-05 22.8 0.9 0.00011 22.0 0.6 1.4 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 1) gp45-slide_C PF09116.5 EPA04700.1 - 0.016 15.1 0.0 0.038 13.9 0.0 1.6 2 0 0 2 2 2 0 gp45 sliding clamp, C terminal GBS_Bsp-like PF08481.5 EPA04700.1 - 0.1 12.5 0.1 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 GBS Bsp-like repeat Complex1_49kDa PF00346.14 EPA04701.1 - 1.7e-21 76.4 0.0 1e-09 37.8 0.0 2.0 1 1 1 2 2 2 2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Ribosomal_S5_C PF03719.10 EPA04701.1 - 0.053 12.7 0.0 0.086 12.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S5, C-terminal domain NADHdh PF00146.16 EPA04702.1 - 1.2e-21 77.0 1.1 2.2e-21 76.2 0.8 1.4 1 0 0 1 1 1 1 NADH dehydrogenase VKOR PF07884.9 EPA04702.1 - 0.22 11.3 0.2 0.22 11.3 0.1 2.1 3 0 0 3 3 3 0 Vitamin K epoxide reductase family Shikimate_dh_N PF08501.6 EPA04703.1 - 5.6e-29 100.0 0.0 8.3e-29 99.4 0.0 1.3 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain WD40_alt PF14077.1 EPA04703.1 - 0.099 12.2 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Alternative WD40 repeat motif DHquinase_I PF01487.10 EPA04704.1 - 8.5e-10 38.6 0.0 8.8e-10 38.6 0.0 1.0 1 0 0 1 1 1 1 Type I 3-dehydroquinase Internalin_N PF12354.3 EPA04705.1 - 0.43 10.2 2.3 0.58 9.8 1.6 1.1 1 0 0 1 1 1 0 Bacterial adhesion/invasion protein N terminal Met_10 PF02475.11 EPA04706.1 - 7.6e-50 169.2 0.2 8.7e-50 169.1 0.1 1.0 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.8 EPA04706.1 - 3.9e-05 22.9 0.1 7.7e-05 21.9 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 EPA04706.1 - 0.00043 20.2 0.0 0.00062 19.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EPA04706.1 - 0.0011 18.4 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 EPA04706.1 - 0.0022 18.5 0.0 0.0035 17.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.21 EPA04706.1 - 0.011 15.2 0.0 0.052 13.1 0.0 2.0 3 0 0 3 3 3 0 Zinc-binding dehydrogenase Methyltransf_15 PF09445.5 EPA04706.1 - 0.011 15.2 0.1 0.023 14.2 0.1 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_16 PF10294.4 EPA04706.1 - 0.012 15.0 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_31 PF13847.1 EPA04706.1 - 0.012 15.1 0.1 0.024 14.2 0.1 1.5 2 0 0 2 2 2 0 Methyltransferase domain DNA_methylase PF00145.12 EPA04706.1 - 0.031 13.4 0.0 0.051 12.6 0.0 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase ABC_tran PF00005.22 EPA04707.1 - 2.6e-19 69.8 0.5 6.4e-19 68.6 0.4 1.6 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EPA04707.1 - 9.9e-07 29.0 1.7 0.0014 18.6 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.1 EPA04707.1 - 0.00033 19.8 1.1 0.32 9.9 0.0 2.2 1 1 1 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 EPA04707.1 - 0.0013 17.9 1.8 0.0037 16.5 1.2 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Miro PF08477.8 EPA04707.1 - 0.018 15.5 0.0 0.058 13.8 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein NB-ARC PF00931.17 EPA04707.1 - 0.088 11.6 0.0 0.32 9.8 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain DUF367 PF04034.8 EPA04709.1 - 1.7e-35 121.3 0.0 2.4e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 EPA04709.1 - 6.5e-07 28.8 0.1 1e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI DUF3408 PF11888.3 EPA04711.1 - 0.027 14.3 2.2 0.027 14.3 1.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3408) HlyD_2 PF12700.2 EPA04711.1 - 0.043 12.9 1.3 0.047 12.8 0.9 1.0 1 0 0 1 1 1 0 HlyD family secretion protein Pam17 PF08566.5 EPA04711.1 - 0.055 13.1 0.3 0.074 12.7 0.2 1.1 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 Cytadhesin_P30 PF07271.6 EPA04711.1 - 0.14 11.3 3.0 0.19 10.9 2.1 1.1 1 0 0 1 1 1 0 Cytadhesin P30/P32 Vma12 PF11712.3 EPA04711.1 - 0.35 10.5 2.0 0.41 10.3 1.4 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Cid2 PF09774.4 EPA04711.1 - 0.41 10.7 4.8 0.47 10.5 3.4 1.1 1 0 0 1 1 1 0 Caffeine-induced death protein 2 CitT PF12431.3 EPA04711.1 - 2.1 8.4 10.4 18 5.5 0.0 3.6 3 0 0 3 3 3 0 Transcriptional regulator AIRS_C PF02769.17 EPA04712.1 - 5.4e-24 84.9 0.0 1.1e-23 83.8 0.0 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.19 EPA04712.1 - 7.5e-17 61.3 0.9 1.5e-16 60.3 0.6 1.5 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain NfeD PF01957.13 EPA04713.1 - 0.028 14.5 0.1 0.028 14.5 0.1 1.1 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding TBP PF00352.16 EPA04714.1 - 2e-61 203.3 0.0 2.5e-30 103.6 0.0 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 EPA04714.1 - 7.1e-07 29.2 0.0 0.00052 20.0 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Na_H_Exchanger PF00999.16 EPA04715.1 - 1.2e-65 221.5 52.9 1.5e-65 221.1 36.6 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family PspB PF06667.7 EPA04715.1 - 0.18 11.7 0.0 0.18 11.7 0.0 1.9 2 0 0 2 2 2 0 Phage shock protein B tRNA_bind PF01588.15 EPA04716.1 - 8.5e-23 80.0 0.0 9.5e-23 79.8 0.0 1.0 1 0 0 1 1 1 1 Putative tRNA binding domain Adenine_glyco PF03352.8 EPA04717.1 - 6.6e-83 276.6 0.5 7.7e-83 276.3 0.3 1.0 1 0 0 1 1 1 1 Methyladenine glycosylase DUF1049 PF06305.6 EPA04718.1 - 0.039 13.4 1.3 0.039 13.4 0.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) YrhK PF14145.1 EPA04718.1 - 0.1 12.2 2.1 0.88 9.2 1.3 1.9 1 1 0 1 1 1 0 YrhK-like protein DUF4366 PF14283.1 EPA04718.1 - 0.11 11.8 0.1 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF1129 PF06570.6 EPA04718.1 - 0.14 11.4 0.4 0.15 11.3 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Glycos_transf_2 PF00535.21 EPA04719.1 - 2.5e-30 105.3 0.1 3.5e-30 104.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 EPA04719.1 - 2.3e-21 76.6 0.0 3.3e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 EPA04719.1 - 7.7e-10 38.3 0.1 1.2e-09 37.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EPA04719.1 - 3.6e-09 36.1 0.0 7.8e-09 35.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.1 EPA04719.1 - 0.00014 22.1 0.0 0.00024 21.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 HILPDA PF15220.1 EPA04719.1 - 0.3 11.0 1.4 0.8 9.7 0.0 2.4 3 0 0 3 3 3 0 Hypoxia-inducible lipid droplet-associated DUF1512 PF07431.7 EPA04720.1 - 1.1e-100 336.9 4.4 1.3e-100 336.6 3.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1512) Trypsin_2 PF13365.1 EPA04721.1 - 1.1e-21 76.9 0.2 2.4e-21 75.9 0.2 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 EPA04721.1 - 2.8e-15 56.4 0.7 1.4e-14 54.2 0.1 2.2 2 1 0 2 2 2 1 Trypsin PDZ_2 PF13180.1 EPA04721.1 - 2e-13 50.0 5.0 2.3e-13 49.8 0.5 2.7 2 1 0 2 2 2 1 PDZ domain Peptidase_S29 PF02907.10 EPA04721.1 - 0.0028 17.1 0.1 0.0051 16.3 0.0 1.4 1 0 0 1 1 1 1 Hepatitis C virus NS3 protease Peptidase_S46 PF10459.4 EPA04721.1 - 0.0079 14.6 1.1 0.013 13.9 0.2 1.6 2 0 0 2 2 2 1 Peptidase S46 PDZ PF00595.19 EPA04721.1 - 0.02 15.0 1.6 3.3 7.9 0.3 3.2 3 0 0 3 3 3 0 PDZ domain (Also known as DHR or GLGF) Peptidase_S32 PF05579.8 EPA04721.1 - 0.029 13.3 2.5 2.2 7.1 0.3 2.3 1 1 1 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Peptidase_S7 PF00949.16 EPA04721.1 - 0.14 11.5 4.0 0.25 10.7 0.7 2.3 2 0 0 2 2 2 0 Peptidase S7, Flavivirus NS3 serine protease DUF3990 PF13151.1 EPA04722.1 - 0.041 13.2 0.0 0.052 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) DLH PF01738.13 EPA04723.1 - 1.2e-51 175.1 0.0 1.5e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 EPA04723.1 - 2.4e-17 63.0 0.1 4.2e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EPA04723.1 - 2.7e-07 30.7 0.0 3.8e-06 26.9 0.0 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EPA04723.1 - 2.6e-06 26.8 0.0 0.021 14.0 0.1 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family Chlorophyllase PF07224.6 EPA04723.1 - 4.6e-06 25.6 0.0 6.9e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase BAAT_C PF08840.6 EPA04723.1 - 3.7e-05 23.5 0.2 0.0024 17.5 0.0 2.4 1 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Chlorophyllase2 PF12740.2 EPA04723.1 - 5.3e-05 22.2 0.0 7.1e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_1 PF00561.15 EPA04723.1 - 0.0023 17.5 0.0 0.0032 17.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold PAF-AH_p_II PF03403.8 EPA04723.1 - 0.017 13.4 0.0 0.096 10.9 0.0 1.8 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Sds3 PF08598.6 EPA04724.1 - 0.058 12.9 1.6 0.072 12.6 1.1 1.1 1 0 0 1 1 1 0 Sds3-like tRNA-synt_1f PF01921.13 EPA04725.1 - 1.9e-108 362.3 0.0 7.9e-108 360.3 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (K) PolyA_pol_RNAbd PF12627.2 EPA04725.1 - 0.011 15.2 0.0 0.031 13.8 0.0 1.7 1 0 0 1 1 1 0 Probable RNA and SrmB- binding site of polymerase A tRNA-synt_1g PF09334.6 EPA04725.1 - 0.042 12.5 0.0 0.15 10.6 0.0 1.8 1 1 0 1 1 1 0 tRNA synthetases class I (M) Radical_SAM PF04055.16 EPA04726.1 - 6e-21 75.3 0.3 9.8e-21 74.6 0.2 1.3 1 0 0 1 1 1 1 Radical SAM superfamily TIM-br_sig_trns PF09370.5 EPA04726.1 - 0.11 11.4 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 TIM-barrel signal transduction protein Metallothio_Euk PF12749.2 EPA04727.1 - 0.19 11.8 7.3 0.21 11.6 5.0 1.1 1 0 0 1 1 1 0 Eukaryotic metallothionein zf-RING-like PF08746.6 EPA04727.1 - 0.43 10.6 10.7 0.54 10.3 7.4 1.1 1 0 0 1 1 1 0 RING-like domain AhpC-TSA PF00578.16 EPA04728.1 - 1.7e-41 140.7 0.3 2e-41 140.5 0.2 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EPA04728.1 - 2.2e-27 95.4 0.1 2.5e-27 95.2 0.1 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.1 EPA04728.1 - 6.8e-08 32.4 0.0 1.2e-07 31.6 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF899 PF05988.7 EPA04728.1 - 5.7e-07 29.1 0.0 6.5e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) SCO1-SenC PF02630.9 EPA04728.1 - 0.00043 19.9 0.7 0.0017 18.0 0.5 1.8 1 1 0 1 1 1 1 SCO1/SenC Thioredoxin_2 PF13098.1 EPA04728.1 - 0.0054 16.9 0.1 0.0097 16.0 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain GSHPx PF00255.14 EPA04728.1 - 0.018 14.3 0.1 0.046 13.1 0.0 1.7 1 1 1 2 2 2 0 Glutathione peroxidase zf-C2H2_3 PF13878.1 EPA04728.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO UMPH-1 PF05822.7 EPA04729.1 - 0.046 13.0 0.4 3.6 6.8 0.0 2.1 1 1 0 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) DUF4396 PF14342.1 EPA04729.1 - 0.092 12.8 1.9 0.084 12.9 0.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4396) DUF443 PF04276.7 EPA04729.1 - 0.1 12.0 8.4 1.3 8.4 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF443) PDR_CDR PF06422.7 EPA04729.1 - 1.4 8.6 4.2 0.37 10.4 0.2 2.0 2 1 1 3 3 3 0 CDR ABC transporter DUF1538 PF07556.6 EPA04729.1 - 2 7.4 7.9 0.64 9.0 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1538) SPC25 PF06703.6 EPA04729.1 - 3 7.3 5.4 0.32 10.5 0.6 1.7 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) TctB PF07331.6 EPA04729.1 - 3.8 7.1 6.1 3.5 7.2 1.4 2.1 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family YqzM PF14141.1 EPA04729.1 - 9.8 6.0 7.6 0.68 9.7 0.9 2.3 3 0 0 3 3 3 0 YqzM-like protein WEMBL PF05701.6 EPA04730.1 - 0.00047 18.7 47.1 0.018 13.5 21.8 2.1 1 1 1 2 2 2 2 Weak chloroplast movement under blue light MscS_porin PF12795.2 EPA04730.1 - 0.00072 18.9 14.4 0.00072 18.9 10.0 3.1 2 1 1 3 3 3 1 Mechanosensitive ion channel porin domain Reo_sigmaC PF04582.7 EPA04730.1 - 0.0049 16.0 2.6 0.0049 16.0 1.8 2.2 1 1 1 2 2 2 1 Reovirus sigma C capsid protein DUF948 PF06103.6 EPA04730.1 - 0.0094 15.7 4.3 0.0094 15.7 3.0 3.6 3 1 1 4 4 4 1 Bacterial protein of unknown function (DUF948) Streptin-Immun PF11083.3 EPA04730.1 - 0.0097 15.8 33.4 0.26 11.2 2.3 4.4 2 1 2 4 4 4 4 Lantibiotic streptin immunity protein DUF3407 PF11887.3 EPA04730.1 - 0.075 12.3 2.7 0.39 9.9 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3407) DUF3584 PF12128.3 EPA04730.1 - 0.16 9.2 39.1 0.22 8.8 27.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) EzrA PF06160.7 EPA04730.1 - 0.19 9.8 42.4 0.51 8.4 9.4 3.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF869 PF05911.6 EPA04730.1 - 0.2 9.8 41.4 0.28 9.3 28.7 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) Filament PF00038.16 EPA04730.1 - 0.58 9.5 41.1 0.014 14.9 10.6 3.2 1 1 0 1 1 1 0 Intermediate filament protein IncA PF04156.9 EPA04730.1 - 1.1 8.8 46.8 2.2 7.8 6.3 3.1 1 1 2 3 3 3 0 IncA protein Laminin_II PF06009.7 EPA04730.1 - 1.1 9.0 34.5 0.42 10.3 9.0 3.2 1 1 1 3 3 3 0 Laminin Domain II Spc7 PF08317.6 EPA04730.1 - 1.8 7.1 46.7 0.61 8.6 21.1 2.7 1 1 0 2 2 2 0 Spc7 kinetochore protein COG2 PF06148.6 EPA04730.1 - 2.3 8.1 25.4 3.1 7.6 1.4 4.0 2 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 AAA_21 PF13304.1 EPA04730.1 - 5.5 6.8 17.0 28 4.5 11.8 1.9 1 1 0 1 1 1 0 AAA domain Phage_hub_GP28 PF11110.3 EPA04730.1 - 6.6 6.3 9.1 2.3 7.8 0.2 2.7 2 1 0 2 2 2 0 Baseplate hub distal subunit Atg14 PF10186.4 EPA04730.1 - 7.1 5.4 40.9 31 3.3 18.6 3.0 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DnaJ_CXXCXGXG PF00684.14 EPA04731.1 - 0.0037 17.2 0.5 0.0051 16.8 0.4 1.3 1 0 0 1 1 1 1 DnaJ central domain Zn-ribbon_8 PF09723.5 EPA04731.1 - 0.028 14.3 3.2 0.072 13.0 2.2 1.6 1 1 0 1 1 1 0 Zinc ribbon domain Nop10p PF04135.7 EPA04731.1 - 0.064 13.0 1.3 0.29 10.8 0.1 2.0 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family OrfB_Zn_ribbon PF07282.6 EPA04731.1 - 0.087 12.4 1.4 0.13 11.9 1.0 1.3 1 1 0 1 1 1 0 Putative transposase DNA-binding domain Nudix_N_2 PF14803.1 EPA04731.1 - 0.095 12.4 0.2 0.87 9.3 0.2 2.0 1 1 0 1 1 1 0 Nudix N-terminal zf-RanBP PF00641.13 EPA04731.1 - 0.12 11.4 2.8 2.2 7.4 0.1 2.1 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Fer4_2 PF12797.2 EPA04731.1 - 0.21 11.5 1.0 5.1 7.2 0.1 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain DZR PF12773.2 EPA04731.1 - 0.44 10.4 3.1 0.72 9.7 2.1 1.4 1 1 0 1 1 1 0 Double zinc ribbon zf-C2H2_3 PF13878.1 EPA04731.1 - 4.2 7.0 5.3 2.7 7.6 0.2 2.1 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO HTH_45 PF14947.1 EPA04732.1 - 0.0099 15.6 0.1 0.017 14.9 0.1 1.5 1 1 0 1 1 1 1 Winged helix-turn-helix Radical_SAM PF04055.16 EPA04733.1 - 3.6e-12 46.7 0.0 8.7e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily BATS PF06968.8 EPA04733.1 - 0.001 18.8 0.1 0.0029 17.4 0.1 1.7 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain SpoU_sub_bind PF08032.7 EPA04733.1 - 0.015 15.4 0.3 6.8 6.9 0.0 4.0 4 1 1 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding ArsC PF03960.10 EPA04733.1 - 0.064 13.3 1.1 0.95 9.5 0.1 2.8 2 1 1 3 3 3 0 ArsC family Ish1 PF10281.4 EPA04733.1 - 0.092 12.8 0.4 2.3 8.3 0.0 2.7 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein Radical_SAM PF04055.16 EPA04734.1 - 3.4e-19 69.6 1.0 6.3e-19 68.7 0.0 2.0 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 EPA04734.1 - 1.5e-05 24.9 0.0 4.3e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EPA04734.1 - 0.04 14.0 0.1 0.19 11.9 0.1 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain MIP PF00230.15 EPA04735.1 - 7.4e-54 182.6 18.9 8.7e-54 182.3 13.1 1.0 1 0 0 1 1 1 1 Major intrinsic protein Ldr_toxin PF13940.1 EPA04735.1 - 0.00061 19.5 0.4 0.0021 17.7 0.3 2.0 1 0 0 1 1 1 1 Toxin Ldr, type I toxin-antitoxin system Peptidase_M24 PF00557.19 EPA04736.1 - 3.6e-38 131.2 1.4 1.9e-37 128.8 1.0 1.8 1 1 0 1 1 1 1 Metallopeptidase family M24 Tn7_Tnp_TnsA_C PF08721.6 EPA04736.1 - 0.0096 15.9 0.0 0.31 11.0 0.0 2.9 3 1 0 3 3 3 1 TnsA endonuclease C terminal ApbE PF02424.10 EPA04736.1 - 0.046 13.0 0.0 0.07 12.4 0.0 1.3 1 0 0 1 1 1 0 ApbE family Sp100 PF03172.8 EPA04736.1 - 0.092 12.7 0.1 15 5.6 0.0 2.3 2 0 0 2 2 2 0 Sp100 domain ATP-cone PF03477.11 EPA04736.1 - 0.12 12.8 1.5 17 5.9 0.1 3.0 3 0 0 3 3 3 0 ATP cone domain PAC2 PF09754.4 EPA04738.1 - 2e-43 148.8 0.0 2.4e-43 148.5 0.0 1.0 1 0 0 1 1 1 1 PAC2 family Ferritin PF00210.19 EPA04739.1 - 6.4e-39 132.9 1.1 7.4e-39 132.7 0.7 1.0 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.12 EPA04739.1 - 5.9e-06 26.6 0.9 7.6e-06 26.2 0.7 1.2 1 0 0 1 1 1 1 Rubrerythrin Lipoprotein_10 PF03202.8 EPA04739.1 - 0.013 15.5 0.5 0.036 14.0 0.3 1.7 1 0 0 1 1 1 0 Putative mycoplasma lipoprotein, C-terminal region NPV_P10 PF05531.7 EPA04740.1 - 0.00053 20.1 0.8 0.00064 19.9 0.5 1.1 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein MtrG PF04210.8 EPA04740.1 - 0.0096 15.5 1.8 0.019 14.6 0.8 1.7 1 1 1 2 2 2 1 Tetrahydromethanopterin S-methyltransferase, subunit G IncA PF04156.9 EPA04740.1 - 0.012 15.2 7.9 0.023 14.2 5.5 1.5 1 1 0 1 1 1 0 IncA protein Viral_P18 PF04521.8 EPA04740.1 - 0.014 14.8 1.9 0.014 14.8 1.3 1.4 1 1 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein Nup54 PF13874.1 EPA04740.1 - 0.021 14.4 2.6 0.024 14.3 1.8 1.1 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 BLOC1_2 PF10046.4 EPA04740.1 - 0.028 14.5 6.4 0.042 13.9 4.4 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TipAS PF07739.8 EPA04740.1 - 0.042 14.1 1.2 0.042 14.1 0.8 1.7 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain OmpH PF03938.9 EPA04740.1 - 0.06 13.2 6.8 0.063 13.2 4.7 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Seryl_tRNA_N PF02403.17 EPA04740.1 - 0.065 13.2 8.1 0.038 14.0 4.1 1.4 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain TMF_TATA_bd PF12325.3 EPA04740.1 - 0.069 12.8 7.5 0.091 12.4 5.1 1.3 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding GAS PF13851.1 EPA04740.1 - 0.071 12.3 13.2 0.079 12.1 9.1 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Toxin_52 PF15605.1 EPA04740.1 - 0.072 12.9 4.1 0.09 12.6 2.8 1.1 1 0 0 1 1 1 0 Putative toxin 52 BBP1_C PF15272.1 EPA04740.1 - 0.075 12.5 11.1 0.079 12.5 7.7 1.1 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal Dor1 PF04124.7 EPA04740.1 - 0.077 11.4 4.5 0.09 11.2 3.1 1.1 1 0 0 1 1 1 0 Dor1-like family Spc7 PF08317.6 EPA04740.1 - 0.11 11.0 8.5 0.14 10.7 5.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein MscS_porin PF12795.2 EPA04740.1 - 0.11 11.7 6.3 0.12 11.6 4.3 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Vps5 PF09325.5 EPA04740.1 - 0.13 11.5 7.3 0.22 10.7 5.1 1.4 1 1 0 1 1 1 0 Vps5 C terminal like DUF1690 PF07956.6 EPA04740.1 - 0.13 12.2 9.1 0.14 12.0 6.3 1.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) YkyA PF10368.4 EPA04740.1 - 0.15 11.4 13.1 0.17 11.2 9.1 1.1 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein DUF3584 PF12128.3 EPA04740.1 - 0.15 9.3 7.1 0.16 9.2 4.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FAM178 PF14816.1 EPA04740.1 - 0.16 10.6 8.5 0.17 10.5 5.9 1.0 1 0 0 1 1 1 0 Family of unknown function, FAM178 HALZ PF02183.13 EPA04740.1 - 0.16 11.7 10.4 0.059 13.0 2.9 2.1 1 1 1 2 2 2 0 Homeobox associated leucine zipper RmuC PF02646.11 EPA04740.1 - 0.16 10.7 3.9 0.19 10.5 2.7 1.0 1 0 0 1 1 1 0 RmuC family DUF4446 PF14584.1 EPA04740.1 - 0.17 11.7 5.5 0.19 11.5 3.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DNA_repr_REX1B PF14966.1 EPA04740.1 - 0.17 12.2 1.8 0.19 12.0 1.2 1.1 1 0 0 1 1 1 0 DNA repair REX1-B FadA PF09403.5 EPA04740.1 - 0.17 11.8 10.9 0.23 11.4 7.5 1.2 1 0 0 1 1 1 0 Adhesion protein FadA DUF883 PF05957.8 EPA04740.1 - 0.18 12.1 2.6 0.3 11.5 1.8 1.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) TMF_DNA_bd PF12329.3 EPA04740.1 - 0.22 11.3 11.0 0.39 10.5 7.6 1.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Myb_DNA-bind_4 PF13837.1 EPA04740.1 - 0.25 11.5 5.7 0.5 10.5 3.9 1.5 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain Syntaxin_2 PF14523.1 EPA04740.1 - 0.25 11.3 7.0 2.5 8.1 0.2 2.1 1 1 1 2 2 2 0 Syntaxin-like protein DUF2951 PF11166.3 EPA04740.1 - 0.26 11.1 10.2 0.28 11.0 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) DUF948 PF06103.6 EPA04740.1 - 0.34 10.7 2.5 1.5 8.6 0.9 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Cir_Bir_Yir PF06022.6 EPA04740.1 - 0.36 10.0 9.1 0.37 9.9 6.3 1.0 1 0 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir FlxA PF14282.1 EPA04740.1 - 0.36 10.7 7.0 1.4 8.8 4.9 1.8 1 1 0 1 1 1 0 FlxA-like protein DUF349 PF03993.7 EPA04740.1 - 0.4 10.8 6.5 0.59 10.3 3.7 1.7 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) Mnd1 PF03962.10 EPA04740.1 - 0.42 10.2 8.3 0.5 10.0 5.8 1.1 1 0 0 1 1 1 0 Mnd1 family V_ATPase_I PF01496.14 EPA04740.1 - 0.55 8.0 8.0 0.54 8.0 5.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vir_act_alpha_C PF10400.4 EPA04740.1 - 0.56 10.6 3.4 0.49 10.8 0.2 1.9 1 1 1 2 2 2 0 Virulence activator alpha C-term Synaptonemal_3 PF15191.1 EPA04740.1 - 0.61 9.8 4.4 2.4 7.9 3.0 1.9 1 1 0 1 1 1 0 Synaptonemal complex central element protein 3 APG6 PF04111.7 EPA04740.1 - 0.66 8.9 11.7 0.7 8.8 8.1 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 Occludin_ELL PF07303.8 EPA04740.1 - 0.71 10.6 9.2 0.92 10.2 6.4 1.2 1 0 0 1 1 1 0 Occludin homology domain DUF3245 PF11595.3 EPA04740.1 - 0.8 9.9 7.8 0.96 9.7 5.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) DUF3818 PF12825.2 EPA04740.1 - 0.84 8.2 5.2 0.97 8.0 3.6 1.0 1 0 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) TBPIP PF07106.8 EPA04740.1 - 0.85 9.1 10.5 1.3 8.5 7.3 1.3 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Sec5 PF15469.1 EPA04740.1 - 0.85 9.3 8.1 1.5 8.5 5.6 1.5 1 1 0 1 1 1 0 Exocyst complex component Sec5 RNA_pol_Rpb1_6 PF04992.9 EPA04740.1 - 0.94 9.1 6.3 1.2 8.8 4.4 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 6 DivIC PF04977.10 EPA04740.1 - 0.95 8.9 9.9 2.5 7.6 1.4 2.0 1 1 1 2 2 2 0 Septum formation initiator DUF1706 PF08020.6 EPA04740.1 - 0.96 8.9 6.4 0.69 9.3 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1706) LUC7 PF03194.10 EPA04740.1 - 0.97 8.9 7.4 0.98 8.9 5.2 1.0 1 0 0 1 1 1 0 LUC7 N_terminus DUF904 PF06005.7 EPA04740.1 - 1 9.7 11.4 3.8 7.8 7.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF904) DASH_Dad3 PF08656.5 EPA04740.1 - 1.1 8.9 5.3 5.4 6.7 3.7 1.9 1 1 0 1 1 1 0 DASH complex subunit Dad3 Spc24 PF08286.6 EPA04740.1 - 1.3 8.7 10.4 14 5.3 7.2 2.0 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF922 PF06037.6 EPA04740.1 - 1.4 8.2 5.1 1.8 7.8 3.5 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) GLE1 PF07817.8 EPA04740.1 - 1.5 7.6 5.1 1.7 7.5 3.5 1.0 1 0 0 1 1 1 0 GLE1-like protein MutS_IV PF05190.13 EPA04740.1 - 1.5 9.0 9.0 0.7 10.1 1.0 2.1 2 0 0 2 2 2 0 MutS family domain IV DUF106 PF01956.11 EPA04740.1 - 1.5 8.2 6.2 1.6 8.2 4.3 1.1 1 0 0 1 1 1 0 Integral membrane protein DUF106 DUF4140 PF13600.1 EPA04740.1 - 1.5 9.2 3.6 5.4 7.5 0.5 1.9 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF972 PF06156.8 EPA04740.1 - 1.7 9.0 8.2 2 8.7 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF3450 PF11932.3 EPA04740.1 - 1.7 7.8 4.8 1.9 7.6 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) YtxH PF12732.2 EPA04740.1 - 1.9 8.8 8.1 38 4.7 5.6 2.0 1 1 0 1 1 1 0 YtxH-like protein CotJB PF12652.2 EPA04740.1 - 2.1 8.4 5.9 6.7 6.8 1.2 2.1 1 1 1 2 2 2 0 CotJB protein Uteroglobin PF01099.12 EPA04740.1 - 2.7 7.8 5.1 3.3 7.5 3.6 1.3 1 0 0 1 1 1 0 Uteroglobin family DUF342 PF03961.8 EPA04740.1 - 2.8 6.2 9.5 3.2 6.0 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Pneumo_ncap PF03246.8 EPA04740.1 - 3.3 6.1 5.2 3.7 5.9 3.6 1.0 1 0 0 1 1 1 0 Pneumovirus nucleocapsid protein FemAB PF02388.11 EPA04740.1 - 3.6 6.1 9.1 3.7 6.1 6.3 1.1 1 0 0 1 1 1 0 FemAB family DUF1227 PF06777.6 EPA04740.1 - 5 6.8 8.0 39 3.9 5.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1227) HJURP_C PF12347.3 EPA04740.1 - 6.2 6.4 13.0 9.8 5.8 3.1 2.4 1 1 1 2 2 2 0 Holliday junction regulator protein family C-terminal repeat DUF1910 PF08928.5 EPA04740.1 - 6.3 6.8 9.2 0.66 10.0 0.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1910) FTCD_C PF04961.7 EPA04740.1 - 6.4 6.1 6.5 5 6.4 1.3 1.9 1 1 1 2 2 2 0 Formiminotransferase-cyclodeaminase TMPIT PF07851.8 EPA04740.1 - 6.9 5.6 8.3 7.7 5.4 5.8 1.0 1 0 0 1 1 1 0 TMPIT-like protein Ax_dynein_light PF10211.4 EPA04740.1 - 9.7 5.9 10.9 12 5.6 7.6 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain Polyketide_cyc2 PF10604.4 EPA04741.1 - 9.9e-10 38.7 0.0 1.1e-09 38.6 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 EPA04741.1 - 2e-05 24.6 0.0 2.5e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AHSA1 PF08327.6 EPA04741.1 - 0.0048 16.9 0.1 0.0056 16.7 0.1 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein DUF493 PF04359.9 EPA04741.1 - 0.022 15.1 0.1 0.04 14.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF493) DUF16 PF01519.11 EPA04741.1 - 0.28 11.4 3.2 0.48 10.6 2.2 1.4 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF4197 PF13852.1 EPA04743.1 - 0.045 13.2 0.0 0.046 13.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4197) Methyltransf_31 PF13847.1 EPA04744.1 - 5.6e-10 38.9 0.2 7.8e-10 38.5 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA04744.1 - 1.4e-09 38.4 0.0 1.9e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EPA04744.1 - 9.4e-08 31.5 0.1 1e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 EPA04744.1 - 3.4e-07 29.7 0.0 4.1e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.15 EPA04744.1 - 3.6e-05 22.9 0.0 4.1e-05 22.8 0.0 1.0 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_26 PF13659.1 EPA04744.1 - 5.1e-05 23.2 0.0 6.3e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 EPA04744.1 - 8.8e-05 22.1 0.0 0.00011 21.8 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.1 EPA04744.1 - 0.00013 22.2 0.0 0.00019 21.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA04744.1 - 0.00027 21.3 0.1 0.00039 20.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EPA04744.1 - 0.00036 19.6 0.1 0.00039 19.5 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_11 PF08241.7 EPA04744.1 - 0.00063 20.1 0.0 0.00096 19.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.8 EPA04744.1 - 0.0017 17.7 0.0 0.0018 17.6 0.0 1.1 1 0 0 1 1 1 1 Histone methylation protein DOT1 PCMT PF01135.14 EPA04744.1 - 0.0033 16.9 0.0 0.0033 16.9 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.13 EPA04744.1 - 0.0063 15.6 0.0 0.0073 15.4 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Cons_hypoth95 PF03602.10 EPA04744.1 - 0.0081 15.5 0.0 0.0088 15.4 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 GCD14 PF08704.5 EPA04744.1 - 0.0099 15.4 0.0 0.011 15.2 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Met_10 PF02475.11 EPA04744.1 - 0.014 14.9 0.0 0.016 14.8 0.0 1.1 1 0 0 1 1 1 0 Met-10+ like-protein FmrO PF07091.6 EPA04744.1 - 0.016 14.2 0.0 0.017 14.1 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_32 PF13679.1 EPA04744.1 - 0.023 14.3 0.0 0.024 14.3 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.12 EPA04744.1 - 0.024 13.7 0.0 0.024 13.6 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase TehB PF03848.9 EPA04744.1 - 0.035 13.2 0.0 0.04 13.0 0.0 1.1 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_23 PF13489.1 EPA04744.1 - 0.038 13.6 0.0 0.04 13.6 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.15 EPA04744.1 - 0.042 12.8 0.0 0.047 12.7 0.0 1.0 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase N6_N4_Mtase PF01555.13 EPA04744.1 - 0.13 11.7 0.1 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 DNA methylase Methyltransf_15 PF09445.5 EPA04744.1 - 0.13 11.7 0.1 0.19 11.2 0.1 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Mut7-C PF01927.11 EPA04745.1 - 1.8e-26 92.8 0.2 2.2e-26 92.6 0.2 1.0 1 0 0 1 1 1 1 Mut7-C RNAse domain DUF569 PF04601.8 EPA04745.1 - 0.12 11.8 0.3 0.97 8.8 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF569) Rab5ip PF07019.7 EPA04746.1 - 0.0023 17.9 6.3 0.006 16.6 4.4 1.7 1 1 0 1 1 1 1 Rab5-interacting protein (Rab5ip) 7TM_GPCR_Srsx PF10320.4 EPA04746.1 - 0.0032 16.6 4.6 0.0045 16.1 3.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx ABC2_membrane_3 PF12698.2 EPA04746.1 - 0.0055 15.7 0.0 0.0057 15.7 0.0 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein RSN1_TM PF13967.1 EPA04746.1 - 0.01 15.3 0.3 0.11 12.0 0.0 2.1 1 1 1 2 2 2 0 Late exocytosis, associated with Golgi transport DUF443 PF04276.7 EPA04746.1 - 0.015 14.7 1.0 0.029 13.7 0.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF443) Multi_Drug_Res PF00893.14 EPA04746.1 - 0.024 15.0 2.6 0.037 14.5 1.8 1.3 1 1 0 1 1 1 0 Small Multidrug Resistance protein Colicin_V PF02674.11 EPA04746.1 - 0.056 13.2 4.6 0.089 12.6 3.2 1.4 1 1 0 1 1 1 0 Colicin V production protein PBP1_TM PF14812.1 EPA04746.1 - 0.088 13.1 1.3 0.12 12.6 0.3 1.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF1686 PF07937.6 EPA04746.1 - 0.093 12.3 0.1 0.17 11.5 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1686) EmrE PF13536.1 EPA04746.1 - 0.14 12.3 4.9 0.099 12.8 2.0 1.7 2 0 0 2 2 2 0 Multidrug resistance efflux transporter DUF202 PF02656.10 EPA04746.1 - 0.27 11.4 7.1 0.16 12.1 0.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF202) DUF3671 PF12420.3 EPA04746.1 - 9 6.3 7.6 23 5.0 5.3 1.8 1 1 0 1 1 1 0 Protein of unknown function Methyltransf_18 PF12847.2 EPA04747.1 - 9.9e-05 22.8 0.0 0.00011 22.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain DUF633 PF04816.7 EPA04747.1 - 0.013 14.8 1.1 0.015 14.6 0.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF633) FbpA PF05833.6 EPA04748.1 - 5.9e-41 140.4 7.6 7.3e-41 140.1 5.2 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF814 PF05670.8 EPA04748.1 - 9.2e-16 57.5 0.0 2.5e-15 56.0 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF814) Tweety PF04906.8 EPA04748.1 - 3.3 6.0 7.1 4.4 5.6 1.0 2.2 1 1 0 2 2 2 0 Tweety zf-like PF04071.7 EPA04749.1 - 0.04 13.6 0.2 0.04 13.6 0.1 1.0 1 0 0 1 1 1 0 Cysteine-rich small domain zf-met PF12874.2 EPA04749.1 - 0.049 13.8 0.6 0.059 13.5 0.4 1.2 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-like PF04071.7 EPA04752.1 - 0.041 13.5 0.1 0.041 13.5 0.1 1.0 1 0 0 1 1 1 0 Cysteine-rich small domain zf-met PF12874.2 EPA04752.1 - 0.059 13.6 0.6 0.072 13.3 0.4 1.2 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Transaldolase PF00923.14 EPA04754.1 - 1.1e-44 152.7 0.0 1.7e-44 152.0 0.0 1.3 1 1 0 1 1 1 1 Transaldolase DUF1125 PF06563.6 EPA04755.1 - 0.081 12.6 0.3 0.093 12.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1125) Usp PF00582.21 EPA04756.1 - 1.9e-22 79.9 0.0 2.3e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family CorA PF01544.13 EPA04757.1 - 1.2e-65 221.4 3.2 1.4e-65 221.2 2.2 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein CesA PF11439.3 EPA04757.1 - 0.024 14.5 1.9 0.12 12.2 0.6 2.6 2 1 0 2 2 2 0 Type III secretion system filament chaperone CesA PhoU_div PF01865.11 EPA04757.1 - 0.032 13.4 4.6 0.58 9.2 0.1 2.2 1 1 0 2 2 2 0 Protein of unknown function DUF47 DUF4319 PF14203.1 EPA04757.1 - 0.044 13.3 1.4 0.81 9.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4319) MRL1 PF13003.2 EPA04757.1 - 0.059 13.1 0.2 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein L1 Cu-binding_MopE PF11617.3 EPA04759.1 - 0.015 15.1 4.0 0.039 13.7 2.8 1.8 1 0 0 1 1 1 0 Protein metal binding site Peptidase_M50 PF02163.17 EPA04762.1 - 1.3e-17 63.3 7.8 2e-16 59.5 4.4 2.6 2 1 0 2 2 2 1 Peptidase family M50 Oxidored_q1 PF00361.15 EPA04763.1 - 3.3e-60 203.6 21.6 3.3e-60 203.6 14.9 2.9 4 0 0 4 4 4 2 NADH-Ubiquinone/plastoquinone (complex I), various chains polyprenyl_synt PF00348.12 EPA04765.1 - 2.5e-42 144.5 0.1 3.7e-42 143.9 0.1 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase NADH5_C PF06455.6 EPA04766.1 - 0.00062 19.1 1.5 0.00073 18.9 1.0 1.0 1 0 0 1 1 1 1 NADH dehydrogenase subunit 5 C-terminus TENA_THI-4 PF03070.11 EPA04767.1 - 1.9e-15 57.1 0.5 2.4e-15 56.8 0.3 1.0 1 0 0 1 1 1 1 TENA/THI-4/PQQC family Haem_oxygenas_2 PF14518.1 EPA04767.1 - 1.3e-07 31.7 0.0 9.8e-07 28.9 0.0 2.1 1 1 1 2 2 2 1 Iron-containing redox enzyme DUF2613 PF11021.3 EPA04768.1 - 0.028 14.1 0.3 0.043 13.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) DUF1469 PF07332.6 EPA04768.1 - 0.23 11.1 4.7 0.27 10.9 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) DUF2628 PF10947.3 EPA04768.1 - 0.23 11.2 1.8 0.23 11.2 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) DUF2985 PF11204.3 EPA04768.1 - 0.47 10.2 3.1 0.59 9.9 2.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2985) Claudin_2 PF13903.1 EPA04768.1 - 1.4 8.6 4.8 1.5 8.4 3.3 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF1049 PF06305.6 EPA04768.1 - 1.7 8.1 6.3 0.73 9.3 2.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1049) Met_10 PF02475.11 EPA04769.1 - 1.4e-05 24.7 0.0 1.9e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Acetyltransf_1 PF00583.19 EPA04770.1 - 2.9e-17 62.4 0.2 4.2e-17 61.9 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EPA04770.1 - 1e-09 38.0 0.2 4.1e-09 36.0 0.0 1.8 1 1 1 2 2 2 1 FR47-like protein Acetyltransf_7 PF13508.1 EPA04770.1 - 2.4e-09 37.2 0.4 3.7e-09 36.6 0.3 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EPA04770.1 - 3.7e-09 36.7 0.0 5.4e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EPA04770.1 - 9.9e-06 25.5 0.1 1.8e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EPA04770.1 - 0.0002 21.3 0.1 0.00026 20.9 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EPA04770.1 - 0.00085 19.5 0.1 0.0012 18.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EPA04770.1 - 0.0033 17.2 0.0 0.0077 16.0 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EPA04770.1 - 0.022 14.6 0.1 0.043 13.7 0.0 1.5 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase Pribosyltran PF00156.22 EPA04771.1 - 2.7e-13 49.7 0.2 6.5e-13 48.4 0.1 1.7 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.1 EPA04771.1 - 0.00024 20.4 0.2 0.00052 19.3 0.1 1.6 2 0 0 2 2 2 1 Phosphoribosyl transferase UPRTase PF14681.1 EPA04771.1 - 0.00043 19.5 0.2 0.00059 19.1 0.2 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase SmpB PF01668.13 EPA04771.1 - 0.012 15.3 0.1 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 SmpB protein Cu-binding_MopE PF11617.3 EPA04773.1 - 0.02 14.6 4.6 0.056 13.2 3.2 1.8 1 0 0 1 1 1 0 Protein metal binding site Ribosomal_L3 PF00297.17 EPA04775.1 - 2.5e-54 184.4 1.3 2.9e-54 184.2 0.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 DUF371 PF04027.8 EPA04776.1 - 2.8e-42 143.4 0.1 3.1e-42 143.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF371) Ribosomal_L14 PF00238.14 EPA04777.1 - 8.2e-32 109.5 0.6 9.4e-32 109.3 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e EutN_CcmL PF03319.8 EPA04777.1 - 0.1 13.0 0.1 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutN/carboxysome Ribosomal_L22 PF00237.14 EPA04778.1 - 3e-06 27.1 0.1 3.7e-06 26.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ribosomal_L29 PF00831.18 EPA04779.1 - 1.2e-13 50.5 3.5 1.4e-13 50.3 2.4 1.1 1 0 0 1 1 1 1 Ribosomal L29 protein IncA PF04156.9 EPA04779.1 - 0.051 13.1 0.7 0.054 13.0 0.5 1.1 1 0 0 1 1 1 0 IncA protein Snapin_Pallidin PF14712.1 EPA04779.1 - 0.077 13.3 2.1 0.089 13.1 1.5 1.1 1 0 0 1 1 1 0 Snapin/Pallidin BLOC1_2 PF10046.4 EPA04779.1 - 0.11 12.6 0.4 0.12 12.5 0.3 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AcylCoA_dehyd_C PF12186.3 EPA04779.1 - 0.15 11.9 1.1 8.4 6.3 0.1 2.0 1 1 1 2 2 2 0 Acyl-CoA dehydrogenase C terminal TMF_DNA_bd PF12329.3 EPA04779.1 - 0.32 10.8 4.5 1.6 8.6 3.1 2.0 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Ribosomal_S19 PF00203.16 EPA04780.1 - 3.5e-24 84.2 0.1 5.4e-24 83.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 UPF0086 PF01868.11 EPA04781.1 - 1.1e-24 85.9 0.2 1.1e-24 85.8 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function UPF0086 DUF4430 PF14478.1 EPA04781.1 - 0.031 14.3 0.7 0.042 13.8 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4430) Snf7 PF03357.16 EPA04782.1 - 0.0089 15.4 1.0 0.014 14.7 0.7 1.5 1 1 0 1 1 1 1 Snf7 bPH_4 PF06713.6 EPA04782.1 - 0.096 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial PH domain Ribosomal_S3_C PF00189.15 EPA04783.1 - 1.6e-14 53.8 0.7 2.7e-14 53.1 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.12 EPA04783.1 - 6.4e-14 51.2 0.0 1.9e-13 49.7 0.0 1.9 1 0 0 1 1 1 1 KH domain KH_1 PF00013.24 EPA04783.1 - 0.0082 15.7 0.7 0.049 13.2 0.1 2.4 3 0 0 3 3 3 1 KH domain KH_3 PF13014.1 EPA04783.1 - 0.056 13.1 1.5 0.14 11.8 0.5 2.1 2 0 0 2 2 2 0 KH domain AMIN PF11741.3 EPA04783.1 - 0.088 12.7 0.4 13 5.7 0.0 3.0 3 0 0 3 3 3 0 AMIN domain KOW PF00467.24 EPA04784.1 - 7.8e-07 28.5 3.3 1.2e-06 27.9 0.7 2.2 2 0 0 2 2 2 1 KOW motif Methyltrans_RNA PF04452.9 EPA04784.1 - 0.025 13.6 0.6 0.039 13.0 0.2 1.4 1 1 0 1 1 1 0 RNA methyltransferase Ribosomal_S17 PF00366.15 EPA04785.1 - 6.8e-18 64.4 1.8 8.5e-18 64.1 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_L4 PF00573.17 EPA04786.1 - 5.1e-41 140.1 0.1 6e-41 139.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Proteasome PF00227.21 EPA04787.1 - 1.1e-52 178.0 0.3 1.4e-52 177.7 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EPA04787.1 - 1.6e-14 52.9 0.6 5.1e-14 51.2 0.1 2.1 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature WbqC PF08889.6 EPA04788.1 - 0.0047 16.3 0.4 0.0062 16.0 0.3 1.2 1 0 0 1 1 1 1 WbqC-like protein family Ribosomal_L22 PF00237.14 EPA04789.1 - 1.4e-21 76.3 0.1 1.6e-21 76.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e DUF2791 PF10923.3 EPA04789.1 - 0.05 12.2 0.0 0.06 11.9 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) Ribosomal_L23 PF00276.15 EPA04790.1 - 2.1e-12 46.7 0.8 4.6e-12 45.7 0.6 1.6 1 1 0 1 1 1 1 Ribosomal protein L23 DNA_mis_repair PF01119.14 EPA04790.1 - 0.018 14.5 0.1 0.025 14.0 0.0 1.3 1 1 0 1 1 1 0 DNA mismatch repair protein, C-terminal domain RRM_5 PF13893.1 EPA04790.1 - 0.033 14.0 0.3 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EPA04790.1 - 0.11 12.4 0.0 0.27 11.2 0.0 1.7 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Methyltrn_RNA_3 PF02598.12 EPA04791.1 - 7.2e-52 176.5 0.0 8.8e-52 176.2 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase Ribosomal_S4e PF00900.15 EPA04792.1 - 1.5e-22 79.0 0.2 2.5e-22 78.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal family S4e RS4NT PF08071.7 EPA04792.1 - 1e-13 50.8 1.1 1.6e-13 50.2 0.8 1.3 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.20 EPA04792.1 - 0.00031 20.1 0.1 0.00073 18.9 0.1 1.7 1 0 0 1 1 1 1 S4 domain KOW PF00467.24 EPA04792.1 - 0.0039 16.8 0.2 0.023 14.4 0.0 2.5 2 0 0 2 2 2 1 KOW motif Cupredoxin_1 PF13473.1 EPA04793.1 - 1.9e-05 24.4 0.0 3.1e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Cupredoxin-like domain Arch_flagellin PF01917.11 EPA04793.1 - 0.56 9.8 6.1 3 7.4 4.2 2.1 1 1 0 1 1 1 0 Archaebacterial flagellin SVM_signal PF12113.3 EPA04794.1 - 0.36 10.6 3.4 0.76 9.6 2.3 1.6 1 0 0 1 1 1 0 SVM protein signal sequence Transketolase_N PF00456.16 EPA04795.1 - 2.3e-64 217.3 0.7 9.2e-63 212.0 0.5 2.1 1 1 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Ribul_P_3_epim PF00834.14 EPA04795.1 - 1.8e-28 99.0 0.2 2.4e-28 98.6 0.1 1.2 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family DXP_synthase_N PF13292.1 EPA04795.1 - 6.4e-06 25.2 0.0 0.00011 21.2 0.0 2.5 2 1 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.16 EPA04795.1 - 1e-05 25.1 0.0 2.2e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.15 EPA04795.1 - 1e-05 24.4 0.0 1.7e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component XFP_N PF09364.5 EPA04795.1 - 3.4e-05 22.5 0.3 0.00041 19.0 0.0 2.1 2 0 0 2 2 2 1 XFP N-terminal domain DUF393 PF04134.7 EPA04796.1 - 0.0039 18.2 0.0 0.0051 17.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF393 Peptidase_M17 PF00883.16 EPA04797.1 - 1.8e-113 378.5 0.1 2.4e-113 378.1 0.1 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.12 EPA04797.1 - 6.5e-18 64.6 0.1 3.3e-17 62.3 0.0 2.1 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain Peptidase_M17 PF00883.16 EPA04798.1 - 3.3e-114 380.9 0.1 3.7e-114 380.7 0.1 1.0 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Iso_dh PF00180.15 EPA04799.1 - 3.5e-102 341.9 0.4 4.4e-102 341.6 0.3 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PdxA PF04166.7 EPA04799.1 - 0.00062 19.0 0.0 0.0011 18.2 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal phosphate biosynthetic protein PdxA TRL PF13146.1 EPA04799.1 - 0.092 12.7 0.1 0.2 11.6 0.1 1.5 1 0 0 1 1 1 0 TRL-like protein family LeuA_dimer PF08502.5 EPA04801.1 - 3.9e-30 104.3 1.2 5.3e-30 103.9 0.8 1.2 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain DUF4147 PF13660.1 EPA04801.1 - 0.0052 15.9 0.1 0.01 14.9 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) GatB_Yqey PF02637.13 EPA04802.1 - 5.5e-20 71.5 7.1 5.5e-20 71.5 4.9 2.2 3 0 0 3 3 3 1 GatB domain GatB_N PF02934.10 EPA04802.1 - 4.2e-08 32.3 0.0 8.4e-08 31.4 0.0 1.4 1 0 0 1 1 1 1 GatB/GatE catalytic domain GAD PF02938.9 EPA04802.1 - 0.00011 22.2 0.6 0.0012 18.9 0.0 2.6 2 0 0 2 2 2 1 GAD domain Hist_deacetyl PF00850.14 EPA04802.1 - 0.13 11.5 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Histone deacetylase domain CTDII PF01556.13 EPA04803.1 - 6.5e-27 93.2 8.4 2.3e-22 78.6 0.5 3.2 3 0 0 3 3 3 3 DnaJ C terminal domain DnaJ PF00226.26 EPA04803.1 - 9.6e-26 89.3 1.4 1.6e-25 88.6 1.0 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 EPA04803.1 - 5.3e-14 52.0 19.2 9.4e-14 51.2 13.3 1.4 1 0 0 1 1 1 1 DnaJ central domain Asparaginase PF00710.15 EPA04804.1 - 8.8e-79 264.6 0.0 1e-78 264.3 0.0 1.0 1 0 0 1 1 1 1 Asparaginase HSP70 PF00012.15 EPA04805.1 - 2.9e-185 616.6 8.6 3.8e-185 616.2 5.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EPA04805.1 - 5.9e-17 61.2 2.4 1.3e-16 60.1 1.7 1.5 1 1 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.11 EPA04805.1 - 0.00089 18.9 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.6 EPA04805.1 - 0.0059 15.5 0.9 0.037 12.9 0.6 2.0 1 1 1 2 2 2 2 StbA protein DUF3194 PF11419.3 EPA04805.1 - 0.013 15.6 0.3 0.34 11.1 0.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3194) Hydantoinase_A PF01968.13 EPA04805.1 - 0.051 12.6 0.8 0.25 10.4 0.5 2.1 1 1 0 1 1 1 0 Hydantoinase/oxoprolinase Peptidase_M22 PF00814.20 EPA04805.1 - 0.1 12.0 0.1 0.26 10.7 0.0 1.6 2 0 0 2 2 2 0 Glycoprotease family Imm5 PF14423.1 EPA04806.1 - 0.07 12.7 0.1 0.07 12.7 0.1 1.1 1 0 0 1 1 1 0 Immunity protein Imm5 Yippee-Mis18 PF03226.9 EPA04806.1 - 0.096 12.7 0.4 0.15 12.1 0.2 1.3 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly NT5C PF06941.7 EPA04807.1 - 8.1e-11 41.7 2.0 1.3e-10 41.1 1.4 1.2 1 1 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) GatB_N PF02934.10 EPA04808.1 - 9.5e-42 142.8 0.0 1.1e-41 142.5 0.0 1.0 1 0 0 1 1 1 1 GatB/GatE catalytic domain TPR_11 PF13414.1 EPA04810.1 - 1.4e-06 27.8 0.3 1.5e-06 27.7 0.2 1.1 1 0 0 1 1 1 1 TPR repeat TPR_16 PF13432.1 EPA04810.1 - 2.5e-06 27.9 0.0 2.7e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 EPA04810.1 - 8.1e-06 25.2 1.1 0.0031 17.0 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 EPA04810.1 - 1.1e-05 25.6 0.0 1.4e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 EPA04810.1 - 7.2e-05 22.4 0.1 0.0017 18.1 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 EPA04810.1 - 9.8e-05 22.6 0.1 0.00012 22.3 0.1 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.1 EPA04810.1 - 0.00018 21.7 0.2 0.0046 17.3 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 EPA04810.1 - 0.00057 19.8 2.2 0.0016 18.4 0.2 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 EPA04810.1 - 0.019 15.0 0.0 0.02 15.0 0.0 1.1 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 EPA04810.1 - 0.028 14.1 0.5 0.66 9.8 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat HemolysinCabind PF00353.14 EPA04812.1 - 3.4e-18 64.2 75.4 0.00035 20.6 2.9 8.1 4 1 7 11 11 11 10 Hemolysin-type calcium-binding repeat (2 copies) NHL PF01436.16 EPA04812.1 - 0.0018 18.1 0.1 0.0034 17.2 0.1 1.5 1 0 0 1 1 1 1 NHL repeat GCC2_GCC3 PF07699.8 EPA04812.1 - 0.006 16.1 3.5 0.24 10.9 0.3 3.2 1 1 2 3 3 3 3 GCC2 and GCC3 DUF167 PF02594.11 EPA04813.1 - 2.2e-16 59.5 2.3 2.4e-16 59.3 1.6 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 MinE PF03776.9 EPA04813.1 - 0.011 15.2 0.8 0.022 14.2 0.3 1.6 1 1 1 2 2 2 0 Septum formation topological specificity factor MinE NPHI_C PF08469.5 EPA04813.1 - 0.013 15.3 1.3 0.014 15.3 0.9 1.0 1 0 0 1 1 1 0 Nucleoside triphosphatase I C-terminal VirC2 PF07181.6 EPA04813.1 - 0.1 12.0 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 VirC2 protein Acylphosphatase PF00708.13 EPA04814.1 - 7.6e-17 61.2 0.1 8.1e-17 61.1 0.1 1.0 1 0 0 1 1 1 1 Acylphosphatase Ribosomal_L2_C PF03947.13 EPA04815.1 - 5.2e-33 113.6 2.1 7.9e-33 113.0 1.4 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 EPA04815.1 - 2.9e-09 36.7 0.0 1e-08 35.0 0.0 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain DUF2392 PF10288.4 EPA04816.1 - 0.034 14.4 0.1 0.069 13.4 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2392) C1_1 PF00130.17 EPA04816.1 - 0.047 13.4 3.8 0.094 12.4 2.6 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RecR PF02132.10 EPA04816.1 - 0.79 9.2 5.4 2.5 7.6 3.8 1.9 1 0 0 1 1 1 0 RecR protein CDC48_N PF02359.13 EPA04818.1 - 1.6e-29 101.6 0.1 5.4e-29 99.9 0.1 1.8 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain AAA PF00004.24 EPA04818.1 - 9.5e-29 100.2 0.0 1.6e-28 99.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.12 EPA04818.1 - 3.5e-08 32.9 0.1 8.3e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 RuvB_N PF05496.7 EPA04818.1 - 5.2e-08 32.2 0.0 7.5e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EPA04818.1 - 5.3e-06 26.5 0.1 5.9e-05 23.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EPA04818.1 - 6.2e-06 25.4 0.0 1.4e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.1 EPA04818.1 - 6.9e-06 26.1 0.0 1.3e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.8 EPA04818.1 - 2.3e-05 23.2 0.2 5.1e-05 22.1 0.0 1.6 2 0 0 2 2 2 1 TIP49 C-terminus AAA_14 PF13173.1 EPA04818.1 - 8.1e-05 22.5 0.0 0.00014 21.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EPA04818.1 - 0.00014 22.6 0.0 0.0004 21.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EPA04818.1 - 0.00017 21.3 0.2 0.0021 17.8 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EPA04818.1 - 0.0002 21.3 0.0 0.0004 20.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 EPA04818.1 - 0.00022 21.0 0.0 0.00035 20.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EPA04818.1 - 0.00055 19.3 0.0 0.00099 18.5 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 EPA04818.1 - 0.0006 19.5 0.1 0.0015 18.1 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_28 PF13521.1 EPA04818.1 - 0.002 18.1 0.0 0.0034 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 EPA04818.1 - 0.0038 16.8 0.0 0.0079 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 EPA04818.1 - 0.0047 17.0 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.16 EPA04818.1 - 0.006 15.7 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 EPA04818.1 - 0.0061 16.0 0.0 0.016 14.6 0.0 1.7 1 1 0 1 1 1 1 Sigma-54 interaction domain KaiC PF06745.8 EPA04818.1 - 0.011 14.9 0.1 0.031 13.3 0.0 1.7 1 1 0 1 1 1 0 KaiC NB-ARC PF00931.17 EPA04818.1 - 0.013 14.3 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Sigma54_activ_2 PF14532.1 EPA04818.1 - 0.014 15.4 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_18 PF13238.1 EPA04818.1 - 0.018 15.3 0.0 0.03 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 EPA04818.1 - 0.019 13.8 0.0 0.026 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.11 EPA04818.1 - 0.028 13.6 0.0 0.05 12.8 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Arch_ATPase PF01637.13 EPA04818.1 - 0.028 14.1 0.1 0.089 12.4 0.0 1.9 1 1 0 1 1 1 0 Archaeal ATPase NTPase_1 PF03266.10 EPA04818.1 - 0.031 13.9 0.1 0.85 9.3 0.0 2.5 1 1 1 2 2 2 0 NTPase Parvo_NS1 PF01057.12 EPA04818.1 - 0.048 12.5 0.0 0.075 11.8 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF2075 PF09848.4 EPA04818.1 - 0.053 12.4 0.0 0.099 11.5 0.0 1.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.1 EPA04818.1 - 0.055 12.8 0.4 0.18 11.1 0.2 1.8 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.22 EPA04818.1 - 0.09 13.0 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_3 PF07726.6 EPA04818.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 EPA04818.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain TSP_3 PF02412.13 EPA04819.1 - 2.3e-10 39.7 33.1 0.00018 20.9 1.4 5.5 7 0 0 7 7 7 3 Thrombospondin type 3 repeat DUF282 PF03380.9 EPA04819.1 - 0.016 14.9 1.1 2.6 7.8 0.1 2.8 2 0 0 2 2 2 0 Caenorhabditis protein of unknown function, DUF282 FG-GAP PF01839.18 EPA04819.1 - 0.4 10.4 7.2 6 6.6 0.6 3.7 4 0 0 4 4 4 0 FG-GAP repeat Excalibur PF05901.6 EPA04819.1 - 1.2 9.4 11.2 6.4 7.2 0.5 4.0 3 2 0 3 3 3 0 Excalibur calcium-binding domain VCBS PF13517.1 EPA04819.1 - 3 8.2 6.7 7.7 6.9 0.4 3.0 2 2 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TSP_3 PF02412.13 EPA04820.1 - 4.1e-15 54.9 39.2 0.0001 21.6 0.4 5.9 5 2 1 6 6 6 4 Thrombospondin type 3 repeat Excalibur PF05901.6 EPA04820.1 - 0.0035 17.6 10.8 4.3 7.7 0.2 4.6 4 1 0 4 4 4 3 Excalibur calcium-binding domain DUF282 PF03380.9 EPA04820.1 - 0.021 14.5 2.4 25 4.6 0.0 4.3 4 0 0 4 4 4 0 Caenorhabditis protein of unknown function, DUF282 NOPS PF08075.6 EPA04820.1 - 0.15 12.5 8.9 4.4 7.7 0.0 4.5 5 2 0 5 5 5 0 NOPS (NUC059) domain Fer4_15 PF13459.1 EPA04820.1 - 2.4 8.7 8.2 1.7 9.2 1.0 3.4 3 2 0 3 3 3 0 4Fe-4S single cluster domain FG-GAP PF01839.18 EPA04820.1 - 4.1 7.2 18.6 0.84 9.4 0.3 4.3 4 0 0 4 4 4 0 FG-GAP repeat GlutR_dimer PF00745.15 EPA04821.1 - 8.7e-06 25.6 0.0 9.9e-06 25.4 0.0 1.0 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain ALAD PF00490.16 EPA04822.1 - 1.1e-66 224.9 0.3 1.2e-66 224.8 0.2 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase DUF2070 PF09843.4 EPA04822.1 - 0.0002 20.8 0.1 0.00023 20.7 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) NADHdh PF00146.16 EPA04823.1 - 1.2e-21 77.1 1.1 2.2e-21 76.2 0.8 1.4 1 0 0 1 1 1 1 NADH dehydrogenase Complex1_49kDa PF00346.14 EPA04824.1 - 1.7e-21 76.4 0.0 1e-09 37.8 0.0 2.0 1 1 1 2 2 2 2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Ribosomal_S5_C PF03719.10 EPA04824.1 - 0.053 12.7 0.0 0.086 12.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S5, C-terminal domain Lyase_1 PF00206.15 EPA04825.1 - 1.9e-24 86.4 0.1 6e-23 81.5 0.0 2.3 2 0 0 2 2 2 2 Lyase ASL_C2 PF14698.1 EPA04825.1 - 1.7e-15 56.8 0.0 3.4e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal CTP_transf_2 PF01467.21 EPA04826.1 - 0.005 16.9 0.0 0.0064 16.5 0.0 1.4 1 1 0 1 1 1 1 Cytidylyltransferase Biotin_lipoyl PF00364.17 EPA04827.1 - 4.3e-17 61.5 4.7 8.3e-17 60.5 3.2 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.1 EPA04827.1 - 1.6e-10 40.5 2.5 1.5e-09 37.3 0.2 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD PF00529.15 EPA04827.1 - 3.2e-05 23.3 1.6 0.00028 20.3 0.2 2.0 1 1 1 2 2 2 1 HlyD family secretion protein HlyD_3 PF13437.1 EPA04827.1 - 4e-05 23.9 1.2 0.082 13.2 0.0 2.7 3 0 0 3 3 3 2 HlyD family secretion protein HlyD_2 PF12700.2 EPA04827.1 - 0.0014 17.8 0.2 0.0014 17.8 0.1 3.0 2 1 1 3 3 3 2 HlyD family secretion protein GCV_H PF01597.14 EPA04827.1 - 0.0037 16.9 0.6 0.0091 15.6 0.4 1.8 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.1 EPA04827.1 - 0.0052 16.4 1.7 0.011 15.4 1.2 1.6 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Big_3_3 PF13750.1 EPA04827.1 - 0.0082 15.5 1.8 0.022 14.2 0.4 2.0 1 1 1 2 2 2 1 Bacterial Ig-like domain (group 3) DUF2118 PF09891.4 EPA04827.1 - 0.022 14.4 1.2 0.03 14.0 0.1 1.7 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) QRPTase_N PF02749.11 EPA04827.1 - 0.028 14.2 0.1 0.082 12.7 0.0 1.8 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain Peptidase_M23 PF01551.17 EPA04827.1 - 0.043 13.8 1.8 0.59 10.2 0.1 2.7 2 1 1 3 3 3 0 Peptidase family M23 NQRA PF05896.6 EPA04827.1 - 0.047 12.8 0.3 0.071 12.2 0.2 1.2 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) DUF4164 PF13747.1 EPA04827.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Complex1_30kDa PF00329.14 EPA04828.1 - 8e-29 99.9 0.2 3.4e-28 97.8 0.2 1.8 1 1 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit PepSY_2 PF13670.1 EPA04829.1 - 0.031 14.1 0.0 0.031 14.1 0.0 1.0 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain DUF3896 PF13035.1 EPA04830.1 - 0.013 15.5 0.3 0.032 14.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3896) MEF2_binding PF09047.5 EPA04830.1 - 0.031 13.8 11.9 0.34 10.5 0.7 2.9 2 0 0 2 2 2 0 MEF2 binding DUF512 PF04459.7 EPA04830.1 - 0.076 12.0 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF512) Herpes_UL17 PF04559.7 EPA04830.1 - 0.22 10.0 3.8 0.25 9.8 2.7 1.2 1 0 0 1 1 1 0 Herpesvirus UL17 protein Mitofilin PF09731.4 EPA04830.1 - 0.22 10.1 12.6 0.26 9.8 8.8 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Peptidase_C27 PF05407.7 EPA04830.1 - 4.1 7.0 7.6 5.9 6.5 5.2 1.1 1 0 0 1 1 1 0 Rubella virus endopeptidase DivIVA PF05103.8 EPA04830.1 - 6.9 6.7 15.5 23 5.0 0.0 2.3 2 0 0 2 2 2 0 DivIVA protein CDC27 PF09507.5 EPA04830.1 - 9.1 5.3 16.2 11 5.1 11.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Glycos_transf_4 PF00953.16 EPA04831.1 - 1.2e-25 90.1 12.2 1.2e-25 90.1 8.5 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 4 Big_3_3 PF13750.1 EPA04831.1 - 0.089 12.2 0.0 0.19 11.1 0.0 1.5 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) Hexapep PF00132.19 EPA04832.1 - 6.2e-28 95.0 16.8 9.9e-11 40.6 0.5 3.7 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EPA04832.1 - 1.7e-18 65.8 12.0 3.7e-11 42.3 1.9 4.7 5 1 0 5 5 5 3 Hexapeptide repeat of succinyl-transferase DUF1059 PF06348.6 EPA04833.1 - 1.6e-06 27.8 0.2 1.7e-06 27.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) Fer2_BFD PF04324.10 EPA04833.1 - 0.031 14.3 0.0 0.037 14.0 0.0 1.2 1 0 0 1 1 1 0 BFD-like [2Fe-2S] binding domain Trm112p PF03966.11 EPA04834.1 - 2.2e-08 34.3 0.2 6.4e-08 32.8 0.2 1.8 1 1 0 1 1 1 1 Trm112p-like protein Cys_rich_KTR PF14205.1 EPA04834.1 - 0.056 12.9 0.4 0.12 11.8 0.2 1.6 1 1 0 1 1 1 0 Cysteine-rich KTR zf-ribbon_3 PF13248.1 EPA04834.1 - 0.067 12.4 0.2 0.13 11.4 0.2 1.4 1 0 0 1 1 1 0 zinc-ribbon domain HEAT_2 PF13646.1 EPA04835.1 - 1.2e-14 54.3 0.5 9e-10 38.7 0.1 2.9 1 1 2 3 3 3 3 HEAT repeats HEAT PF02985.17 EPA04835.1 - 4.8e-11 41.7 0.0 0.0015 18.4 0.0 4.1 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.1 EPA04835.1 - 8.8e-07 29.2 0.0 0.051 14.0 0.0 3.6 3 1 1 4 4 4 1 HEAT-like repeat Cohesin_HEAT PF12765.2 EPA04835.1 - 1.5e-05 24.7 0.2 0.24 11.3 0.0 3.7 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion DUF2435 PF10363.4 EPA04835.1 - 0.0012 18.7 0.2 0.22 11.4 0.0 3.0 1 1 1 2 2 2 1 Protein of unknown function (DUF2435) Adaptin_N PF01602.15 EPA04835.1 - 0.0016 16.8 1.4 0.013 13.8 1.0 2.2 1 1 0 1 1 1 1 Adaptin N terminal region ERAP1_C PF11838.3 EPA04835.1 - 0.0017 17.6 0.2 0.28 10.3 0.0 2.4 1 1 1 2 2 2 2 ERAP1-like C-terminal domain Arm PF00514.18 EPA04835.1 - 0.0017 18.0 1.3 0.1 12.4 0.0 3.8 4 1 1 5 5 5 1 Armadillo/beta-catenin-like repeat DNA_pol3_delta PF06144.8 EPA04835.1 - 0.0033 16.9 0.5 0.76 9.2 0.0 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit Cnd1 PF12717.2 EPA04835.1 - 0.0041 16.9 0.6 1 9.2 0.0 3.1 1 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.11 EPA04835.1 - 0.023 15.1 0.0 22 5.9 0.0 4.2 5 1 0 5 5 5 0 PBS lyase HEAT-like repeat CLASP_N PF12348.3 EPA04835.1 - 0.029 13.7 0.1 0.083 12.2 0.1 2.1 1 1 0 1 1 1 0 CLASP N terminal DUF4042 PF13251.1 EPA04835.1 - 0.049 13.1 0.1 5.7 6.3 0.0 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4042) V-ATPase_H_C PF11698.3 EPA04835.1 - 0.085 12.7 0.3 2 8.3 0.1 2.7 1 1 0 2 2 2 0 V-ATPase subunit H ArsC PF03960.10 EPA04835.1 - 0.24 11.4 3.3 0.52 10.3 0.1 2.5 2 1 1 3 3 3 0 ArsC family KH_5 PF13184.1 EPA04835.1 - 1.3 8.8 6.3 1 9.2 0.5 3.1 1 1 2 3 3 3 0 NusA-like KH domain DUF59 PF01883.14 EPA04836.1 - 2e-13 50.1 0.1 2.8e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF59 HMA PF00403.21 EPA04836.1 - 0.071 13.2 0.4 1 9.5 0.0 2.3 2 0 0 2 2 2 0 Heavy-metal-associated domain AAA PF00004.24 EPA04837.1 - 1.3e-12 48.0 0.0 3.5e-12 46.6 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 EPA04837.1 - 3.7e-11 42.4 0.5 0.00017 20.4 0.2 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein RuvB_N PF05496.7 EPA04837.1 - 1.9e-08 33.6 0.0 4.2e-08 32.5 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EPA04837.1 - 0.00024 21.9 0.3 0.00081 20.1 0.0 2.1 2 2 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EPA04837.1 - 0.00046 20.0 0.0 0.0014 18.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 EPA04837.1 - 0.00052 18.8 0.0 0.00088 18.0 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_22 PF13401.1 EPA04837.1 - 0.0016 18.5 0.3 0.23 11.6 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.9 EPA04837.1 - 0.0036 17.0 0.2 0.042 13.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 EPA04837.1 - 0.013 15.7 0.3 0.069 13.4 0.0 2.3 2 1 1 3 3 3 0 AAA domain AAA_2 PF07724.9 EPA04837.1 - 0.015 15.1 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_19 PF13245.1 EPA04837.1 - 0.018 14.7 0.1 0.042 13.5 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA_33 PF13671.1 EPA04837.1 - 0.023 14.5 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EPA04837.1 - 0.025 13.7 0.2 0.099 11.7 0.0 2.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.17 EPA04837.1 - 0.037 12.8 0.0 0.06 12.1 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain IstB_IS21 PF01695.12 EPA04837.1 - 0.038 13.3 0.0 0.087 12.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein NTPase_1 PF03266.10 EPA04837.1 - 0.042 13.5 0.0 0.092 12.4 0.0 1.6 1 0 0 1 1 1 0 NTPase Zeta_toxin PF06414.7 EPA04837.1 - 0.053 12.6 0.0 0.084 11.9 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.1 EPA04837.1 - 0.1 12.5 0.0 0.31 10.9 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AhpC-TSA PF00578.16 EPA04838.1 - 8.5e-34 115.9 0.0 9.9e-34 115.6 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EPA04838.1 - 4.9e-22 78.0 0.0 5.6e-22 77.8 0.0 1.0 1 0 0 1 1 1 1 Redoxin SCO1-SenC PF02630.9 EPA04838.1 - 0.013 15.1 0.1 0.019 14.5 0.1 1.3 1 1 0 1 1 1 0 SCO1/SenC Fer2_3 PF13085.1 EPA04839.1 - 4.9e-30 103.5 0.5 8.9e-30 102.7 0.0 1.6 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.1 EPA04839.1 - 2e-12 46.9 4.9 4.4e-12 45.8 1.7 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 EPA04839.1 - 6.6e-11 42.4 6.2 4.1e-09 36.7 0.3 2.6 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_17 PF13534.1 EPA04839.1 - 2.7e-10 40.4 10.9 1.6e-08 34.7 1.5 2.3 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_10 PF13237.1 EPA04839.1 - 1.2e-08 34.5 2.6 1.2e-08 34.5 1.8 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 EPA04839.1 - 1.4e-08 34.8 2.6 1.4e-08 34.8 1.8 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.2 EPA04839.1 - 3.3e-08 33.7 14.3 7.5e-07 29.4 3.4 2.6 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_2 PF12797.2 EPA04839.1 - 3.1e-05 23.6 12.0 3.2e-05 23.5 0.7 3.3 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4 PF00037.22 EPA04839.1 - 3.4e-05 23.2 1.0 3.4e-05 23.2 0.7 3.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer2 PF00111.22 EPA04839.1 - 0.00017 21.2 0.1 0.00017 21.2 0.1 1.8 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_16 PF13484.1 EPA04839.1 - 0.0011 19.6 4.5 0.0011 19.6 3.2 2.3 2 1 0 2 2 2 1 4Fe-4S double cluster binding domain Fer4_6 PF12837.2 EPA04839.1 - 0.0023 17.7 1.5 0.0023 17.7 1.0 2.8 3 0 0 3 3 2 1 4Fe-4S binding domain Fer4_4 PF12800.2 EPA04839.1 - 0.087 13.2 2.0 0.087 13.2 1.4 3.3 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_3 PF12798.2 EPA04839.1 - 0.15 12.6 0.9 0.15 12.6 0.6 3.1 3 0 0 3 3 2 0 4Fe-4S binding domain Fer4_21 PF14697.1 EPA04839.1 - 0.25 11.2 13.1 0.16 11.8 5.4 2.8 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_15 PF13459.1 EPA04839.1 - 0.5 10.9 0.2 0.5 10.9 0.1 2.8 3 0 0 3 3 2 0 4Fe-4S single cluster domain Myticin-prepro PF10690.4 EPA04840.1 - 0.13 12.2 6.6 0.2 11.7 4.6 1.3 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel Inositol_P PF00459.20 EPA04841.1 - 4.4e-31 108.1 0.0 5.1e-31 107.9 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.15 EPA04841.1 - 2.1e-06 26.8 0.1 6.8e-06 25.1 0.0 1.8 2 0 0 2 2 2 1 Fructose-1-6-bisphosphatase Lyase_1 PF00206.15 EPA04842.1 - 7.3e-06 25.3 0.7 9e-06 25.0 0.5 1.1 1 0 0 1 1 1 1 Lyase Latrotoxin_C PF15658.1 EPA04842.1 - 0.076 12.8 2.0 0.096 12.5 1.4 1.2 1 0 0 1 1 1 0 Latrotoxin C-terminal domain Aminotran_4 PF01063.14 EPA04843.1 - 9.2e-41 139.8 0.0 1.1e-40 139.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV Sdh_cyt PF01127.17 EPA04844.1 - 7.4e-09 35.4 2.2 8.6e-09 35.2 1.5 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF4405 PF14358.1 EPA04844.1 - 0.033 14.3 3.5 0.85 9.8 0.6 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4405) Cytochrom_B_N_2 PF13631.1 EPA04844.1 - 0.038 13.7 0.8 0.061 13.1 0.5 1.3 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_N PF00033.14 EPA04844.1 - 2.2 7.5 6.7 11 5.2 4.7 2.0 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB CcmD PF04995.9 EPA04844.1 - 2.4 7.9 5.2 3.6 7.4 0.1 2.6 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) CPSase_L_D2 PF02786.12 EPA04845.1 - 5.1e-69 231.7 0.0 7.6e-69 231.2 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 EPA04845.1 - 2.1e-42 143.6 0.1 4e-42 142.7 0.1 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 EPA04845.1 - 2.5e-32 111.0 0.0 5.2e-32 110.0 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 EPA04845.1 - 2.5e-17 63.2 0.0 4.7e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EPA04845.1 - 4.8e-13 48.5 0.0 7.5e-12 44.6 0.0 2.1 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 EPA04845.1 - 4.1e-10 39.2 0.1 8.9e-10 38.1 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.6 EPA04845.1 - 1.5e-09 37.5 0.0 1.4e-08 34.4 0.0 2.2 1 1 0 1 1 1 1 RimK-like ATP-grasp domain Dala_Dala_lig_C PF07478.8 EPA04845.1 - 8.4e-08 31.8 0.2 2.4e-07 30.3 0.2 1.7 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 EPA04845.1 - 7.7e-07 29.1 0.0 1.7e-06 27.9 0.0 1.6 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 EPA04845.1 - 0.07 12.6 0.3 0.26 10.7 0.0 2.0 3 0 0 3 3 3 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain NAD_binding_1 PF00175.16 EPA04846.1 - 8.2e-15 55.3 0.0 1.6e-14 54.3 0.0 1.5 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EPA04846.1 - 5e-11 42.5 0.0 8.2e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 EPA04846.1 - 0.038 13.9 0.1 0.13 12.1 0.1 1.9 1 1 1 2 2 2 0 Ferric reductase NAD binding domain NAD_binding_1 PF00175.16 EPA04847.1 - 3.3e-13 50.1 0.0 6.4e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EPA04847.1 - 3.7e-10 39.7 0.0 6e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 EPA04847.1 - 0.036 13.9 0.2 0.12 12.2 0.0 1.9 1 1 1 2 2 2 0 Ferric reductase NAD binding domain Carboxyl_trans PF01039.17 EPA04848.1 - 5e-186 618.8 0.0 5.7e-186 618.6 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.6 EPA04848.1 - 1.5e-06 27.5 0.0 3.1e-06 26.5 0.0 1.5 2 0 0 2 2 2 1 Malonate decarboxylase gamma subunit (MdcE) Peptidase_S49_N PF08496.5 EPA04849.1 - 0.15 11.8 0.6 0.22 11.2 0.4 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal AA_permease PF00324.16 EPA04849.1 - 1.4 7.1 13.9 1.6 6.9 9.6 1.1 1 0 0 1 1 1 0 Amino acid permease Sec62 PF03839.11 EPA04849.1 - 1.6 8.0 9.5 2.3 7.5 6.6 1.4 1 1 0 1 1 1 0 Translocation protein Sec62 DUF4212 PF13937.1 EPA04849.1 - 2.8 8.0 9.8 3.6 7.6 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4212) MFS_1 PF07690.11 EPA04850.1 - 1.7e-34 119.1 28.5 1.7e-34 119.1 19.7 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EPA04850.1 - 1.8e-33 115.8 32.3 1e-30 106.7 22.4 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.1 EPA04850.1 - 2.2e-12 46.1 21.8 6.3e-12 44.6 15.0 1.7 1 1 0 1 1 1 1 MFS/sugar transport protein DUF791 PF05631.9 EPA04850.1 - 0.00011 21.0 3.0 0.0083 14.8 0.6 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF791) FPN1 PF06963.7 EPA04850.1 - 0.00012 20.5 0.7 0.00012 20.5 0.5 2.4 3 0 0 3 3 3 1 Ferroportin1 (FPN1) MFS_1_like PF12832.2 EPA04850.1 - 0.0022 17.7 5.6 0.0061 16.3 1.2 2.9 2 0 0 2 2 2 1 MFS_1 like family ATG22 PF11700.3 EPA04850.1 - 0.0027 16.2 10.9 0.0027 16.2 7.6 2.4 1 1 1 2 2 2 1 Vacuole effluxer Atg22 like Pex24p PF06398.6 EPA04850.1 - 1.3 7.7 5.8 0.11 11.2 0.9 1.5 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin zf-DHHC PF01529.15 EPA04850.1 - 4.2 6.7 5.9 14 5.0 4.1 1.9 1 0 0 1 1 1 0 DHHC palmitoyltransferase Complex1_49kDa PF00346.14 EPA04851.1 - 9.8e-30 103.4 0.0 1.5e-29 102.9 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit DUF3195 PF11424.3 EPA04851.1 - 0.058 13.5 0.6 0.56 10.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3195) Oxidored_q6 PF01058.17 EPA04852.1 - 6.6e-25 87.2 0.1 9.1e-25 86.7 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit PadR PF03551.9 EPA04853.1 - 8.3e-11 41.5 0.1 1.5e-10 40.6 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_45 PF14947.1 EPA04853.1 - 6.5e-06 25.8 0.2 7.2e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix Mrr_N PF14338.1 EPA04853.1 - 0.012 15.6 0.1 0.1 12.7 0.0 2.2 2 0 0 2 2 2 0 Mrr N-terminal domain Motilin_assoc PF04643.7 EPA04853.1 - 0.04 13.4 0.5 0.22 11.0 0.1 2.1 2 0 0 2 2 2 0 Motilin/ghrelin-associated peptide DisA-linker PF10635.4 EPA04853.1 - 0.08 12.4 0.4 0.12 11.8 0.3 1.2 1 0 0 1 1 1 0 DisA bacterial checkpoint controller linker region HemN_C PF06969.11 EPA04853.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 HemN C-terminal domain Sdh_cyt PF01127.17 EPA04854.1 - 9.9e-08 31.8 4.2 1.5e-07 31.2 2.5 1.6 1 1 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Oxidored_q4 PF00507.14 EPA04856.1 - 2.6e-15 56.0 1.6 4.7e-15 55.2 1.1 1.4 1 1 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 GlutR_N PF05201.10 EPA04858.1 - 2.2e-30 105.2 0.0 3.2e-30 104.7 0.0 1.3 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.15 EPA04858.1 - 3e-13 50.0 0.0 7.8e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 EPA04858.1 - 0.0032 17.7 0.0 0.0083 16.3 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding DUF498 PF04430.9 EPA04858.1 - 0.0032 16.9 0.2 2.3 7.7 0.0 3.1 3 1 1 4 4 4 2 Protein of unknown function (DUF498/DUF598) K_oxygenase PF13434.1 EPA04858.1 - 0.053 12.4 0.0 0.089 11.6 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) 2-Hacid_dh_C PF02826.14 EPA04858.1 - 0.1 11.7 0.1 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PEP_mutase PF13714.1 EPA04859.1 - 4.1e-54 183.3 0.1 4.8e-54 183.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.16 EPA04859.1 - 6.7e-17 60.8 0.1 2.9e-16 58.8 0.0 1.8 2 0 0 2 2 2 1 Isocitrate lyase family FAD_binding_2 PF00890.19 EPA04860.1 - 1.7e-98 330.2 0.1 2e-98 329.9 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 EPA04860.1 - 2.7e-40 137.1 0.5 4.6e-40 136.4 0.3 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.9 EPA04860.1 - 1.5e-05 24.9 6.0 0.0049 16.7 4.2 3.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EPA04860.1 - 0.0002 20.5 0.1 0.0024 17.0 0.1 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 EPA04860.1 - 0.00068 18.6 0.0 0.037 12.8 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A DAO PF01266.19 EPA04860.1 - 0.0038 16.1 0.0 0.16 10.8 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.12 EPA04860.1 - 0.012 14.7 0.1 0.043 12.9 0.0 2.0 2 0 0 2 2 2 0 Thi4 family Lycopene_cycl PF05834.7 EPA04860.1 - 0.021 13.7 0.1 0.038 12.8 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.9 EPA04860.1 - 0.036 12.5 0.5 2.1 6.7 0.1 2.6 3 0 0 3 3 3 0 HI0933-like protein GFO_IDH_MocA PF01408.17 EPA04861.1 - 5.2e-26 91.5 0.0 8.9e-26 90.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EPA04861.1 - 5.8e-08 32.5 0.0 1e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Semialdhyde_dh PF01118.19 EPA04861.1 - 0.0058 16.9 0.1 0.018 15.3 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Peptidase_M73 PF12389.3 EPA04861.1 - 0.051 13.0 0.1 0.12 11.8 0.0 1.6 2 0 0 2 2 2 0 Camelysin metallo-endopeptidase NAD_binding_3 PF03447.11 EPA04861.1 - 0.1 12.9 0.1 0.9 9.9 0.0 2.1 2 0 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain DUF4352 PF11611.3 EPA04862.1 - 0.00043 20.4 0.3 0.00063 19.8 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4352) DUF721 PF05258.7 EPA04863.1 - 0.018 15.2 0.0 0.031 14.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF721) Sar8_2 PF03058.9 EPA04863.1 - 0.058 13.7 0.0 0.085 13.1 0.0 1.3 1 0 0 1 1 1 0 Sar8.2 family DNA_gyraseA_C PF03989.8 EPA04865.1 - 0.013 14.8 0.5 0.066 12.5 0.3 2.0 1 1 0 1 1 1 0 DNA gyrase C-terminal domain, beta-propeller Thioredoxin_4 PF13462.1 EPA04866.1 - 1.4e-35 122.6 0.0 1.9e-35 122.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.15 EPA04866.1 - 3.5e-12 46.2 0.0 6.7e-11 42.0 0.0 2.1 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.1 EPA04866.1 - 2.1e-08 34.3 0.0 7.1e-08 32.6 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EPA04866.1 - 0.0015 18.5 0.3 0.13 12.3 0.2 2.4 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_5 PF13743.1 EPA04866.1 - 0.026 14.1 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Peptidase_S24 PF00717.18 EPA04868.1 - 6.4e-09 35.3 0.4 1.2e-08 34.5 0.3 1.4 1 0 0 1 1 1 1 Peptidase S24-like DUF606 PF04657.8 EPA04868.1 - 0.015 15.3 4.9 0.03 14.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF606 DUF202 PF02656.10 EPA04868.1 - 0.016 15.4 6.3 0.6 10.3 1.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF202) DUF1129 PF06570.6 EPA04868.1 - 0.075 12.3 11.5 0.52 9.5 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) DUF1686 PF07937.6 EPA04868.1 - 0.27 10.8 2.8 3.6 7.1 0.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1686) Claudin_2 PF13903.1 EPA04868.1 - 2.8 7.6 8.5 1.6 8.4 4.3 1.7 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF373 PF04123.8 EPA04868.1 - 4.6 6.1 13.2 12 4.8 9.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF373) O-antigen_lig PF13425.1 EPA04868.1 - 6.4 6.7 20.1 22 4.9 0.9 3.1 2 1 1 3 3 3 0 O-antigen ligase like membrane protein EamA PF00892.15 EPA04869.1 - 4.5e-13 49.3 9.9 5.3e-13 49.1 5.9 1.7 1 1 1 2 2 2 1 EamA-like transporter family Cation_ATPase_C PF00689.16 EPA04869.1 - 0.034 13.6 6.2 0.042 13.3 4.3 1.2 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus DUF1129 PF06570.6 EPA04869.1 - 0.53 9.5 4.4 1.6 7.9 3.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) DUF3671 PF12420.3 EPA04869.1 - 1.8 8.5 10.1 0.5 10.3 2.2 2.2 1 1 1 2 2 2 0 Protein of unknown function NfeD PF01957.13 EPA04869.1 - 2.1 8.4 6.1 0.5 10.5 0.6 1.9 1 1 1 2 2 2 0 NfeD-like C-terminal, partner-binding MacB_PCD PF12704.2 EPA04870.1 - 0.11 12.0 1.7 5 6.6 1.5 2.1 1 1 1 2 2 2 0 MacB-like periplasmic core domain DUF3293 PF11697.3 EPA04871.1 - 0.021 14.9 0.0 0.022 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3293) zf-C2H2_2 PF12756.2 EPA04873.1 - 0.0023 17.9 0.1 0.0026 17.8 0.1 1.0 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.7 EPA04873.1 - 0.009 16.1 0.1 0.0099 15.9 0.1 1.1 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 EPA04873.1 - 0.057 13.7 0.6 0.084 13.2 0.4 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 EPA04873.1 - 0.082 13.0 0.3 0.15 12.2 0.2 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding ABC_tran PF00005.22 EPA04875.1 - 3e-19 69.6 0.0 4.7e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter RLI PF04068.10 EPA04875.1 - 4.2e-12 45.4 3.6 4.2e-12 45.4 2.5 2.1 2 0 0 2 2 2 1 Possible Fer4-like domain in RNase L inhibitor, RLI Fer4 PF00037.22 EPA04875.1 - 7.6e-09 34.8 13.4 1.2e-08 34.2 3.7 2.8 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_6 PF12837.2 EPA04875.1 - 1.1e-08 34.5 16.1 1.6e-07 30.8 3.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.2 EPA04875.1 - 8.2e-07 28.5 12.1 4.4e-06 26.2 2.1 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 EPA04875.1 - 6.6e-06 26.4 12.1 1.9e-05 24.9 8.5 1.7 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_21 PF14697.1 EPA04875.1 - 2.1e-05 24.2 12.4 3.7e-05 23.4 8.6 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 EPA04875.1 - 2.6e-05 23.9 24.8 0.00013 21.6 1.4 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain SMC_N PF02463.14 EPA04875.1 - 7e-05 22.1 1.3 0.00081 18.6 0.9 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EPA04875.1 - 0.0001 22.3 2.5 0.0091 15.9 1.7 2.1 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 EPA04875.1 - 0.0024 17.0 0.0 0.0045 16.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Fer4_9 PF13187.1 EPA04875.1 - 0.0026 17.9 14.3 0.0055 16.9 9.9 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_3 PF12798.2 EPA04875.1 - 0.0027 18.1 5.4 0.0027 18.1 3.7 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_4 PF12800.2 EPA04875.1 - 0.0039 17.4 3.4 0.0039 17.4 2.3 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_17 PF13534.1 EPA04875.1 - 0.0064 16.8 4.5 0.036 14.4 0.2 2.6 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_29 PF13555.1 EPA04875.1 - 0.0082 15.6 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Fer4_16 PF13484.1 EPA04875.1 - 0.015 16.0 13.4 0.38 11.5 9.5 2.4 1 1 1 2 2 2 0 4Fe-4S double cluster binding domain Fer4_11 PF13247.1 EPA04875.1 - 0.02 14.7 4.7 0.034 14.0 3.2 1.3 1 0 0 1 1 1 0 4Fe-4S dicluster domain AAA_16 PF13191.1 EPA04875.1 - 0.036 14.0 0.1 0.12 12.3 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain Fer4_8 PF13183.1 EPA04875.1 - 0.039 13.9 1.5 0.039 13.9 1.0 1.7 1 1 1 2 2 2 0 4Fe-4S dicluster domain MMR_HSR1 PF01926.18 EPA04875.1 - 0.12 12.3 0.6 0.21 11.5 0.4 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase ArgK PF03308.11 EPA04875.1 - 0.13 10.9 0.0 0.32 9.7 0.0 1.6 1 0 0 1 1 1 0 ArgK protein Fer4_18 PF13746.1 EPA04875.1 - 1.2 9.5 12.0 0.12 12.7 3.3 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_15 PF13459.1 EPA04875.1 - 1.3 9.6 12.5 0.13 12.8 2.6 2.7 1 1 1 2 2 2 0 4Fe-4S single cluster domain Mut7-C PF01927.11 EPA04877.1 - 0.0022 17.9 0.0 0.0023 17.9 0.0 1.0 1 0 0 1 1 1 1 Mut7-C RNAse domain DUF4411 PF14367.1 EPA04877.1 - 0.073 12.7 0.0 0.075 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) Penicillinase_R PF03965.11 EPA04879.1 - 0.00065 19.7 0.1 0.0012 18.8 0.1 1.5 1 0 0 1 1 1 1 Penicillinase repressor DUF4504 PF14953.1 EPA04879.1 - 0.0038 16.5 0.8 0.74 9.0 0.1 2.5 1 1 2 3 3 3 2 Domain of unknown function (DUF4504) HxlR PF01638.12 EPA04883.1 - 0.0089 15.6 0.5 0.074 12.6 0.1 2.2 2 1 0 2 2 2 1 HxlR-like helix-turn-helix APG17 PF04108.7 EPA04883.1 - 0.017 13.9 2.5 0.02 13.7 1.7 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 Hemagglutinin PF00509.13 EPA04883.1 - 0.026 12.6 4.1 0.038 12.1 2.8 1.3 1 1 0 1 1 1 0 Haemagglutinin Carbpep_Y_N PF05388.6 EPA04883.1 - 0.064 13.4 1.0 0.95 9.6 0.2 2.2 1 1 1 2 2 2 0 Carboxypeptidase Y pro-peptide DUF2746 PF10874.3 EPA04883.1 - 0.074 13.2 0.4 2.1 8.5 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2746) SLA_LP_auto_ag PF05889.8 EPA04883.1 - 0.092 11.1 2.7 0.18 10.2 0.5 2.1 1 1 1 2 2 2 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) YflT PF11181.3 EPA04883.1 - 0.11 12.6 1.3 0.29 11.3 0.9 1.7 1 0 0 1 1 1 0 Heat induced stress protein YflT Lge1 PF11488.3 EPA04883.1 - 0.21 11.8 1.6 0.72 10.0 0.6 2.1 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 DUF2018 PF09442.5 EPA04883.1 - 1.2 9.7 5.8 2.1 8.9 0.9 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF2018) Ycf66_N PF07444.6 EPA04884.1 - 3.2e-05 23.5 0.5 0.0024 17.5 0.0 2.1 1 1 1 2 2 2 1 Ycf66 protein N-terminus Oxidored_q3 PF00499.15 EPA04884.1 - 0.0064 16.2 1.2 0.0077 16.0 0.8 1.1 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Cytochrom_B_N PF00033.14 EPA04884.1 - 0.0098 15.2 0.3 0.012 14.9 0.2 1.1 1 0 0 1 1 1 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B561 PF03188.11 EPA04884.1 - 0.015 15.1 2.2 0.025 14.4 1.5 1.4 1 1 0 1 1 1 0 Eukaryotic cytochrome b561 EmrE PF13536.1 EPA04884.1 - 0.018 15.2 1.2 0.018 15.2 0.9 1.5 1 1 0 1 1 1 0 Multidrug resistance efflux transporter PepSY_TM_3 PF13706.1 EPA04884.1 - 0.055 12.8 2.9 1.5 8.3 0.0 2.6 2 1 0 2 2 2 0 PepSY-associated TM helix PhaG_MnhG_YufB PF03334.9 EPA04884.1 - 0.082 12.9 3.1 0.35 10.9 2.2 1.8 1 1 0 1 1 1 0 Na+/H+ antiporter subunit DUF2644 PF10841.3 EPA04884.1 - 0.1 12.6 0.8 6.2 6.9 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2644) FixQ PF05545.6 EPA04884.1 - 0.11 12.1 1.1 0.17 11.5 0.0 1.8 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DUF4064 PF13273.1 EPA04884.1 - 0.12 12.4 3.1 0.17 12.0 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) Tetraspannin PF00335.15 EPA04884.1 - 0.39 9.9 1.7 0.46 9.7 1.1 1.0 1 0 0 1 1 1 0 Tetraspanin family DUF2768 PF10966.3 EPA04884.1 - 0.4 10.8 2.8 2 8.6 1.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2768) DAP_B PF07930.7 EPA04885.1 - 0.054 13.2 0.0 0.071 12.8 0.0 1.2 1 0 0 1 1 1 0 D-aminopeptidase, domain B Zn-ribbon_8 PF09723.5 EPA04886.1 - 0.023 14.6 2.3 0.89 9.5 0.0 2.2 1 1 1 2 2 2 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.7 EPA04886.1 - 0.092 12.0 1.9 0.15 11.4 1.3 1.4 1 1 0 1 1 1 0 TFIIB zinc-binding PhnA_Zn_Ribbon PF08274.7 EPA04886.1 - 0.22 11.3 1.6 0.29 10.9 1.1 1.1 1 0 0 1 1 1 0 PhnA Zinc-Ribbon SWIB PF02201.13 EPA04887.1 - 0.0051 16.4 0.0 0.0083 15.7 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain DUF4662 PF15578.1 EPA04887.1 - 2 7.9 6.6 1.7 8.1 4.1 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4662) ADH_zinc_N PF00107.21 EPA04888.1 - 5.3e-31 106.8 0.1 1e-30 105.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EPA04888.1 - 1.7e-22 79.2 0.0 2.8e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 EPA04888.1 - 5.9e-16 59.5 0.1 1.2e-15 58.5 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ACP_syn_III_C PF08541.5 EPA04888.1 - 0.05 13.6 0.1 0.14 12.2 0.1 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Glyco_hydro_35 PF01301.14 EPA04889.1 - 0.0042 16.4 0.1 0.021 14.1 0.1 2.1 3 0 0 3 3 3 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.10 EPA04889.1 - 0.019 14.1 0.1 0.049 12.7 0.0 1.7 2 0 0 2 2 2 0 Beta-galactosidase DUF4296 PF14129.1 EPA04889.1 - 0.044 13.9 0.1 0.18 11.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4296) Hydrophob_seed PF14547.1 EPA04890.1 - 0.85 9.5 3.6 0.64 9.9 0.6 2.1 2 1 1 3 3 3 0 Hydrophobic seed protein Amidohydro_1 PF01979.15 EPA04891.1 - 6.8e-27 94.9 0.2 3.8e-26 92.5 0.2 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EPA04891.1 - 4.8e-11 42.3 0.0 1.8e-10 40.4 0.0 2.0 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_4 PF13147.1 EPA04891.1 - 6.9e-11 42.6 0.0 0.00016 21.7 0.0 2.5 2 1 0 2 2 2 2 Amidohydrolase Amidohydro_3 PF07969.6 EPA04891.1 - 1.6e-06 27.5 0.0 0.00032 20.0 0.0 2.4 2 1 0 2 2 2 2 Amidohydrolase family TPR_11 PF13414.1 EPA04892.1 - 6.7e-31 105.7 9.6 1.4e-11 43.8 0.1 3.5 2 1 2 4 4 4 4 TPR repeat TPR_1 PF00515.23 EPA04892.1 - 6e-24 82.6 7.5 1.7e-07 30.5 0.0 5.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.1 EPA04892.1 - 9.3e-19 67.1 1.8 2.2e-06 27.5 0.1 3.8 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.12 EPA04892.1 - 4e-17 60.6 0.8 0.00059 19.5 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat Apc3 PF12895.2 EPA04892.1 - 4.1e-12 46.0 7.7 1.2e-05 25.3 0.6 2.2 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 EPA04892.1 - 4.5e-12 46.2 0.0 0.00021 21.8 0.0 3.0 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 EPA04892.1 - 2.6e-10 39.3 14.8 0.0018 17.9 0.3 6.5 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.1 EPA04892.1 - 5.9e-10 38.1 0.2 0.026 14.2 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 EPA04892.1 - 8.2e-10 38.1 6.0 0.015 15.4 0.1 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 EPA04892.1 - 2.2e-09 37.5 0.7 0.0075 16.5 0.1 3.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 EPA04892.1 - 7.8e-09 35.3 0.0 1.9 9.3 0.0 5.2 1 1 5 6 6 5 2 Tetratricopeptide repeat TPR_10 PF13374.1 EPA04892.1 - 1.7e-08 34.1 0.0 0.0054 16.6 0.0 3.9 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 EPA04892.1 - 1.2e-06 28.2 0.0 0.11 12.4 0.0 2.9 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.1 EPA04892.1 - 4.6e-06 26.7 0.1 4.6 7.9 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EPA04892.1 - 6.6e-06 25.9 3.7 2.4 8.1 0.1 4.6 5 0 0 5 5 5 2 Fis1 C-terminal tetratricopeptide repeat Phage_Treg PF04761.7 EPA04892.1 - 0.00029 20.5 0.1 0.084 12.6 0.0 2.9 3 0 0 3 3 3 1 Lactococcus bacteriophage putative transcription regulator NARP1 PF12569.3 EPA04892.1 - 0.00047 19.0 1.1 0.0036 16.1 0.1 2.1 1 1 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_15 PF13429.1 EPA04892.1 - 0.00051 19.1 0.4 0.013 14.5 0.4 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat MIT PF04212.13 EPA04892.1 - 0.0011 18.8 1.7 0.058 13.2 0.2 3.2 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain DUF627 PF04781.7 EPA04892.1 - 0.0016 18.0 0.4 0.38 10.3 0.0 3.1 2 1 0 2 2 2 1 Protein of unknown function (DUF627) DUF3856 PF12968.2 EPA04892.1 - 0.0018 18.1 0.1 1.9 8.3 0.0 3.9 1 1 3 4 4 4 1 Domain of Unknown Function (DUF3856) Alkyl_sulf_dimr PF14863.1 EPA04892.1 - 0.0032 17.6 0.1 1.1 9.4 0.1 2.3 2 0 0 2 2 2 1 Alkyl sulfatase dimerisation Coatomer_E PF04733.9 EPA04892.1 - 0.0078 15.4 3.3 0.35 10.0 0.2 2.3 1 1 1 2 2 2 2 Coatomer epsilon subunit DUF4615 PF15393.1 EPA04892.1 - 0.026 14.7 0.4 0.046 13.9 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4615) TPR_20 PF14561.1 EPA04892.1 - 0.045 13.8 1.5 4.3 7.5 0.0 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat UvsY PF11056.3 EPA04892.1 - 0.57 10.3 6.2 2.6 8.1 0.1 3.2 2 2 0 3 3 2 0 Recombination, repair and ssDNA binding protein UvsY PPTA PF01239.17 EPA04892.1 - 0.82 9.1 3.0 0.86 9.0 0.5 2.3 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat DUF1021 PF06257.6 EPA04893.1 - 0.059 13.0 0.2 0.068 12.8 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1021) DUF4415 PF14384.1 EPA04893.1 - 0.07 13.2 0.0 0.11 12.7 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4415) RibD_C PF01872.12 EPA04894.1 - 6.1e-18 65.1 0.0 6.5e-18 65.0 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain dsDNA_bind PF01984.15 EPA04895.1 - 2.3e-23 82.2 2.1 2.6e-23 82.0 1.4 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain DMRL_synthase PF00885.14 EPA04896.1 - 1.1e-28 99.6 0.3 1.2e-28 99.5 0.2 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Sua5_yciO_yrdC PF01300.13 EPA04897.1 - 2.1e-60 203.0 0.0 3.4e-60 202.3 0.0 1.3 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.8 EPA04897.1 - 4.2e-28 97.9 0.1 7e-28 97.2 0.0 1.4 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding DUF1792 PF08759.6 EPA04897.1 - 0.024 14.2 1.1 0.42 10.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1792) EF-hand_1 PF00036.27 EPA04897.1 - 0.07 12.4 0.5 0.51 9.7 0.0 2.7 3 0 0 3 3 3 0 EF hand Oxidored_q6 PF01058.17 EPA04897.1 - 0.13 11.8 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase, 20 Kd subunit RibD_C PF01872.12 EPA04898.1 - 3.5e-22 78.9 0.0 3.8e-22 78.8 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain Baculo_LEF-11 PF06385.7 EPA04898.1 - 0.06 13.4 0.0 0.089 12.8 0.0 1.4 1 1 0 1 1 1 0 Baculovirus LEF-11 protein Rpr2 PF04032.11 EPA04899.1 - 4.5e-19 68.1 2.0 5.9e-19 67.7 1.4 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-Sec23_Sec24 PF04810.10 EPA04899.1 - 0.0016 17.9 1.3 0.19 11.3 0.1 2.2 2 0 0 2 2 2 2 Sec23/Sec24 zinc finger DUF3268 PF11672.3 EPA04899.1 - 0.015 15.3 0.1 0.021 14.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3268) C1_1 PF00130.17 EPA04899.1 - 0.096 12.4 0.8 0.17 11.6 0.5 1.4 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Pyr_redox_2 PF07992.9 EPA04900.1 - 1.1e-12 48.2 0.0 2.5e-12 47.1 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EPA04900.1 - 3.6e-07 30.5 0.5 0.0039 17.5 0.6 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EPA04900.1 - 1.2e-05 25.5 0.5 3.1 7.7 0.0 4.0 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EPA04900.1 - 1.4e-05 24.1 0.0 0.038 12.9 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EPA04900.1 - 0.00058 19.6 0.4 0.23 11.2 0.0 3.1 2 1 1 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.19 EPA04900.1 - 0.013 14.4 0.1 0.13 11.1 0.0 2.3 3 0 0 3 3 3 0 FAD dependent oxidoreductase UPF0052 PF01933.13 EPA04900.1 - 0.049 12.9 0.0 0.086 12.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0052 DUF4147 PF13660.1 EPA04900.1 - 0.057 12.5 0.0 2.2 7.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4147) Shikimate_DH PF01488.15 EPA04900.1 - 0.058 13.5 0.3 4.1 7.4 0.1 3.1 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase DHBP_synthase PF00926.14 EPA04901.1 - 5.6e-68 227.9 0.1 6.3e-68 227.8 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase PAF-AH_p_II PF03403.8 EPA04901.1 - 0.05 11.8 0.0 0.069 11.4 0.0 1.3 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Hemerythrin PF01814.18 EPA04902.1 - 2.3e-11 43.9 0.4 1.1e-10 41.7 0.1 2.2 2 1 0 2 2 2 1 Hemerythrin HHE cation binding domain Methyltransf_4 PF02390.12 EPA04902.1 - 0.0031 16.6 2.0 0.0031 16.6 1.4 1.5 2 0 0 2 2 2 1 Putative methyltransferase IZUMO PF15005.1 EPA04902.1 - 0.05 13.6 1.7 0.068 13.2 0.4 1.7 2 0 0 2 2 2 0 Izumo sperm-egg fusion EMG1 PF03587.9 EPA04903.1 - 1.7e-42 144.9 0.3 2e-42 144.8 0.2 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase DUF217 PF02697.9 EPA04903.1 - 0.052 13.8 0.8 0.12 12.6 0.5 1.6 1 0 0 1 1 1 0 Uncharacterized ACR, COG1753 Response_reg PF00072.19 EPA04904.1 - 1.1e-18 67.2 0.0 1.2e-18 67.1 0.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain DUF2608 PF11019.3 EPA04904.1 - 0.084 11.8 0.1 0.34 9.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) DUF356 PF04009.7 EPA04904.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF356) Lum_binding PF00677.12 EPA04905.1 - 2.2e-45 152.4 10.6 3.9e-25 87.5 0.4 2.0 2 0 0 2 2 2 2 Lumazine binding domain Aldedh PF00171.17 EPA04906.1 - 9.5e-123 409.9 0.3 1.1e-122 409.7 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ribosomal_S19e PF01090.14 EPA04908.1 - 1.3e-48 164.0 0.0 1.4e-48 163.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e RuvB_C PF05491.8 EPA04908.1 - 0.11 12.0 0.0 3.1 7.5 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB C-terminus GGDN PF05165.7 EPA04909.1 - 2.9e-51 173.8 0.0 4.1e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 GGDN family Guanylate_cyc PF00211.15 EPA04909.1 - 0.0019 17.6 0.2 0.0035 16.7 0.0 1.6 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain MAF_flag10 PF01973.13 EPA04909.1 - 0.059 12.8 0.1 0.16 11.4 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF115 NOG1 PF06858.9 EPA04909.1 - 0.09 12.6 1.8 0.22 11.4 0.0 2.5 3 0 0 3 3 3 0 Nucleolar GTP-binding protein 1 (NOG1) UFC1 PF08694.6 EPA04909.1 - 0.13 11.7 0.0 0.29 10.5 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin-fold modifier-conjugating enzyme 1 HpcH_HpaI PF03328.9 EPA04910.1 - 1.8e-44 151.2 0.0 2.1e-44 151.0 0.0 1.0 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.1 EPA04910.1 - 7.3e-13 48.0 0.0 4.1e-07 29.1 0.0 2.1 1 1 1 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold PK PF00224.16 EPA04910.1 - 0.017 13.7 0.1 0.023 13.3 0.1 1.1 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain RDD PF06271.7 EPA04912.1 - 9.1e-23 80.6 3.1 1.1e-22 80.4 2.1 1.0 1 0 0 1 1 1 1 RDD family NUT_C PF12882.2 EPA04914.1 - 0.038 13.5 0.0 0.049 13.2 0.0 1.1 1 0 0 1 1 1 0 NUT protein C terminal Methyltransf_11 PF08241.7 EPA04915.1 - 6.2e-11 42.6 0.0 9.9e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA04915.1 - 6.5e-06 25.8 0.0 1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA04915.1 - 0.00075 19.9 0.0 0.0013 19.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA04915.1 - 0.0019 17.9 0.0 0.0031 17.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 EPA04915.1 - 0.0037 16.9 0.0 0.0082 15.7 0.0 1.7 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.9 EPA04915.1 - 0.13 11.6 0.0 1 8.7 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase small domain SAICAR_synt PF01259.13 EPA04916.1 - 3.4e-70 235.9 0.3 4.3e-70 235.6 0.2 1.1 1 0 0 1 1 1 1 SAICAR synthetase DUF2299 PF10061.4 EPA04917.1 - 5.4e-05 22.6 0.2 6.4e-05 22.4 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2299) Ribosomal_S14 PF00253.16 EPA04919.1 - 3e-15 55.3 2.8 3.4e-15 55.1 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e zf-FPG_IleRS PF06827.9 EPA04919.1 - 0.028 14.0 3.7 0.23 11.1 2.8 1.9 1 1 1 2 2 2 0 Zinc finger found in FPG and IleRS DUF2318 PF10080.4 EPA04919.1 - 0.087 12.6 0.2 0.091 12.5 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) zf-AD PF07776.10 EPA04919.1 - 0.14 12.1 1.4 0.27 11.2 0.5 1.7 1 1 1 2 2 2 0 Zinc-finger associated domain (zf-AD) HTH_20 PF12840.2 EPA04920.1 - 1.8e-09 37.2 0.1 3.1e-09 36.4 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.15 EPA04920.1 - 2.7e-07 30.1 0.4 2.2e-06 27.2 0.3 2.2 1 1 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_12 PF08461.5 EPA04920.1 - 1.1e-06 28.2 0.3 2.4e-06 27.1 0.2 1.6 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain FUR PF01475.14 EPA04920.1 - 0.00012 22.0 0.4 0.00026 20.8 0.3 1.7 1 1 0 1 1 1 1 Ferric uptake regulator family HTH_11 PF08279.7 EPA04920.1 - 0.017 14.7 0.8 0.23 11.1 0.6 2.3 1 1 0 1 1 1 0 HTH domain Replic_Relax PF13814.1 EPA04920.1 - 0.021 14.6 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 Replication-relaxation HTH_24 PF13412.1 EPA04920.1 - 0.031 13.6 1.2 0.048 13.0 0.1 2.0 2 1 0 2 2 2 0 Winged helix-turn-helix DNA-binding HU-DNA_bdg PF14848.1 EPA04920.1 - 0.033 13.9 0.7 0.093 12.4 0.3 1.8 1 1 1 2 2 2 0 DNA-binding domain IKI3 PF04762.7 EPA04920.1 - 0.044 11.5 0.0 0.062 11.1 0.0 1.2 1 0 0 1 1 1 0 IKI3 family BAF PF02961.9 EPA04920.1 - 0.066 13.5 0.0 0.18 12.1 0.0 1.7 2 0 0 2 2 2 0 Barrier to autointegration factor Polyketide_cyc2 PF10604.4 EPA04921.1 - 6e-06 26.4 0.0 6.5e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 EPA04921.1 - 0.0018 18.2 0.0 0.0023 17.9 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport COXG PF06240.8 EPA04921.1 - 0.088 12.4 0.0 0.38 10.4 0.0 1.9 1 1 0 1 1 1 0 Carbon monoxide dehydrogenase subunit G (CoxG) Imm27 PF15573.1 EPA04922.1 - 0.088 11.9 0.8 0.12 11.4 0.5 1.2 1 0 0 1 1 1 0 Immunity protein 27 DUF4352 PF11611.3 EPA04923.1 - 1e-10 41.8 2.1 1.3e-10 41.5 1.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4352) Aegerolysin PF06355.8 EPA04923.1 - 0.012 15.4 0.9 0.043 13.6 0.0 2.1 3 0 0 3 3 3 0 Aegerolysin MacB_PCD PF12704.2 EPA04923.1 - 0.035 13.7 1.0 0.044 13.3 0.7 1.2 1 0 0 1 1 1 0 MacB-like periplasmic core domain Pyridox_oxidase PF01243.15 EPA04924.1 - 1.2e-15 57.2 0.0 1.8e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 EPA04924.1 - 0.038 13.8 0.0 0.072 12.9 0.0 1.4 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase PurS PF02700.9 EPA04925.1 - 2.3e-19 69.1 0.4 2.5e-19 69.0 0.3 1.0 1 0 0 1 1 1 1 Phosphoribosylformylglycinamidine (FGAM) synthase AIRS_C PF02769.17 EPA04926.1 - 3.9e-49 166.5 0.3 8.4e-26 90.8 0.2 2.2 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.19 EPA04926.1 - 1.3e-40 137.5 0.2 2.8e-22 78.7 0.2 2.6 2 0 0 2 2 2 2 AIR synthase related protein, N-terminal domain T_Ag_DNA_bind PF02217.11 EPA04926.1 - 0.03 14.7 2.1 0.033 14.5 0.1 2.0 2 0 0 2 2 2 0 Origin of replication binding protein TatC PF00902.13 EPA04928.1 - 3.5e-57 193.2 17.3 4.3e-57 192.9 12.0 1.1 1 0 0 1 1 1 1 Sec-independent protein translocase protein (TatC) Ribosomal_L6 PF00347.18 EPA04929.1 - 1.5e-08 35.0 5.8 3.7e-05 24.1 0.4 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 BON PF04972.12 EPA04929.1 - 0.0067 16.1 4.9 3.3 7.5 0.0 3.9 4 1 1 5 5 5 2 BON domain S_layer_C PF05124.7 EPA04929.1 - 0.066 12.8 0.2 0.097 12.2 0.1 1.3 1 0 0 1 1 1 0 S-layer like family, C-terminal region DUF1127 PF06568.6 EPA04930.1 - 0.067 12.6 0.0 0.081 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1127) GATase_2 PF00310.16 EPA04931.1 - 1.5e-21 76.5 0.0 2.4e-14 52.8 0.0 3.1 2 1 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 EPA04931.1 - 4.5e-16 59.0 0.0 2e-15 56.9 0.0 2.0 3 0 0 3 3 3 1 Glutamine amidotransferase domain GATase_7 PF13537.1 EPA04931.1 - 9.2e-14 51.2 0.0 1.5e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.22 EPA04931.1 - 3.1e-13 49.5 0.0 8.3e-13 48.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.1 EPA04931.1 - 8.9e-07 27.8 0.0 2.6e-06 26.3 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferases class-II PRTase_3 PF15610.1 EPA04931.1 - 0.034 13.0 0.0 0.065 12.1 0.0 1.4 1 0 0 1 1 1 0 PRTase ComF-like Pribosyltran_N PF13793.1 EPA04931.1 - 0.061 13.0 0.1 0.17 11.6 0.1 1.7 1 0 0 1 1 1 0 N-terminal domain of ribose phosphate pyrophosphokinase DUF427 PF04248.7 EPA04932.1 - 2.9e-29 100.5 0.3 3.2e-29 100.4 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF427) DUF1246 PF06849.7 EPA04933.1 - 4.6e-21 74.8 0.0 6e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1246) SIMPL PF04402.9 EPA04934.1 - 2.5e-45 154.9 0.5 3e-45 154.6 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) Internalin_N PF12354.3 EPA04934.1 - 0.86 9.2 3.7 4.2 7.0 0.1 3.0 3 0 0 3 3 3 0 Bacterial adhesion/invasion protein N terminal GATase_5 PF13507.1 EPA04935.1 - 7.3e-06 25.0 0.0 7.9e-06 24.9 0.0 1.0 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase_5 PF13507.1 EPA04937.1 - 1.3e-26 93.0 0.0 1.8e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase_3 PF07685.9 EPA04937.1 - 8.6e-09 35.1 0.0 1.5e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.23 EPA04937.1 - 4.1e-08 32.9 0.0 4.8e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I DJ-1_PfpI PF01965.19 EPA04937.1 - 6.7e-07 28.8 0.0 8.5e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family DUF4066 PF13278.1 EPA04937.1 - 8.5e-06 25.1 0.0 1.4e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Putative amidotransferase Peptidase_C26 PF07722.8 EPA04937.1 - 0.00051 19.5 0.1 0.0012 18.3 0.1 1.6 1 1 0 1 1 1 1 Peptidase C26 SNO PF01174.14 EPA04937.1 - 0.055 13.0 0.0 0.081 12.5 0.0 1.2 1 0 0 1 1 1 0 SNO glutamine amidotransferase family Ribosomal_S8 PF00410.14 EPA04938.1 - 5.6e-21 74.7 0.0 7.1e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 DUF1297 PF06973.7 EPA04939.1 - 1.4e-47 161.4 0.0 1.5e-47 161.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) Ribosomal_L5_C PF00673.16 EPA04941.1 - 2.9e-23 81.3 0.0 4.7e-23 80.7 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 EPA04941.1 - 6.2e-10 38.7 0.2 1.6e-09 37.3 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L5 MttA_Hcf106 PF02416.11 EPA04942.1 - 1.4e-11 43.2 1.3 1.9e-11 42.8 0.9 1.2 1 0 0 1 1 1 1 mttA/Hcf106 family GnsAB PF08178.6 EPA04942.1 - 0.061 12.9 0.9 0.091 12.4 0.6 1.4 1 1 0 1 1 1 0 GnsA/GnsB family RIG-I_C-RD PF11648.3 EPA04943.1 - 0.034 14.0 0.2 0.035 13.9 0.1 1.0 1 0 0 1 1 1 0 C-terminal domain of RIG-I DZR PF12773.2 EPA04943.1 - 0.038 13.7 0.2 0.046 13.5 0.1 1.1 1 0 0 1 1 1 0 Double zinc ribbon zf-C2HC_2 PF13913.1 EPA04943.1 - 0.27 10.9 1.1 0.27 10.9 0.8 1.6 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Pentapeptide PF00805.17 EPA04945.1 - 6.8e-43 143.2 35.6 4.4e-12 44.9 1.2 5.0 1 1 5 6 6 6 6 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.1 EPA04945.1 - 3.8e-19 68.2 0.1 1.6e-11 43.8 0.0 2.1 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.1 EPA04945.1 - 2.7e-15 55.9 0.6 3.1e-05 23.7 0.1 4.2 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Baculo_11_kDa PF06143.6 EPA04946.1 - 0.0007 18.9 0.6 0.00073 18.8 0.4 1.1 1 0 0 1 1 1 1 Baculovirus 11 kDa family Tic20 PF09685.5 EPA04946.1 - 0.024 14.6 0.6 0.024 14.5 0.4 1.0 1 0 0 1 1 1 0 Tic20-like protein COPI_assoc PF08507.5 EPA04946.1 - 0.029 14.0 0.3 0.029 14.0 0.2 1.0 1 0 0 1 1 1 0 COPI associated protein Arteri_Gl PF00951.13 EPA04946.1 - 0.029 13.9 0.2 0.032 13.8 0.2 1.0 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein OSTMP1 PF09777.4 EPA04946.1 - 0.061 12.4 0.1 0.062 12.4 0.1 1.0 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor YrhC PF14143.1 EPA04946.1 - 0.069 13.0 0.4 0.075 12.9 0.3 1.2 1 0 0 1 1 1 0 YrhC-like protein DUF872 PF05915.7 EPA04946.1 - 0.094 12.5 0.1 0.11 12.4 0.1 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) RCR PF12273.3 EPA04946.1 - 0.19 12.2 1.4 0.22 12.0 1.0 1.1 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red SAYSvFN PF10260.4 EPA04946.1 - 1.6 8.5 5.2 2.2 8.0 0.5 2.1 1 1 1 2 2 2 0 Uncharacterized conserved domain (SAYSvFN) Flavoprotein PF02441.14 EPA04947.1 - 9.4e-31 106.1 0.7 1.3e-30 105.7 0.5 1.1 1 0 0 1 1 1 1 Flavoprotein DUF4257 PF14074.1 EPA04949.1 - 0.0012 18.4 0.1 0.0014 18.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4257) MASE2 PF05230.6 EPA04949.1 - 0.0024 17.7 0.1 0.0029 17.5 0.1 1.0 1 0 0 1 1 1 1 MASE2 domain Transgly_assoc PF04226.8 EPA04949.1 - 0.0054 16.7 2.0 0.0078 16.2 1.4 1.3 1 0 0 1 1 1 1 Transglycosylase associated protein 5TM-5TMR_LYT PF07694.7 EPA04949.1 - 0.0095 15.2 0.2 0.012 14.9 0.1 1.1 1 0 0 1 1 1 1 5TMR of 5TMR-LYT Bac_Ubq_Cox PF01654.12 EPA04949.1 - 0.013 13.9 0.1 0.015 13.7 0.0 1.0 1 0 0 1 1 1 0 Bacterial Cytochrome Ubiquinol Oxidase Tic20 PF09685.5 EPA04949.1 - 0.019 14.9 0.2 0.024 14.5 0.2 1.2 1 0 0 1 1 1 0 Tic20-like protein DUF2407_C PF13373.1 EPA04949.1 - 0.021 14.7 0.2 0.027 14.4 0.1 1.2 1 0 0 1 1 1 0 DUF2407 C-terminal domain Cyto_ox_2 PF02322.10 EPA04949.1 - 0.027 13.6 0.0 0.028 13.5 0.0 1.0 1 0 0 1 1 1 0 Cytochrome oxidase subunit II DUF1129 PF06570.6 EPA04949.1 - 0.035 13.4 0.1 0.035 13.4 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) TauE PF01925.14 EPA04949.1 - 0.063 12.7 0.2 0.073 12.5 0.1 1.1 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE Choline_transpo PF04515.7 EPA04949.1 - 0.069 11.8 0.1 0.076 11.7 0.1 1.0 1 0 0 1 1 1 0 Plasma-membrane choline transporter RseC_MucC PF04246.7 EPA04949.1 - 0.097 12.2 0.2 0.12 11.9 0.1 1.1 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC LHC PF00556.15 EPA04949.1 - 0.12 12.1 3.7 5 7.0 0.4 2.1 2 0 0 2 2 2 0 Antenna complex alpha/beta subunit MFS_1 PF07690.11 EPA04949.1 - 0.13 10.9 2.0 0.19 10.3 1.4 1.4 1 1 0 1 1 1 0 Major Facilitator Superfamily Tad PF13400.1 EPA04949.1 - 1.1 9.3 3.4 3 7.9 0.1 2.0 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like Vps39_1 PF10366.4 EPA04950.1 - 0.092 12.7 0.1 0.092 12.7 0.1 1.0 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 AsnC_trans_reg PF01037.16 EPA04951.1 - 1.1e-09 37.8 0.8 1.2e-09 37.7 0.5 1.1 1 0 0 1 1 1 1 AsnC family PRANC PF09372.5 EPA04951.1 - 0.0008 19.3 0.0 0.00096 19.0 0.0 1.0 1 0 0 1 1 1 1 PRANC domain HTH_24 PF13412.1 EPA04952.1 - 2.6e-10 39.4 0.1 5.1e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_5 PF01022.15 EPA04952.1 - 1.6e-09 37.2 0.0 4.4e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.2 EPA04952.1 - 7.7e-09 35.2 0.0 1.2e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_11 PF08279.7 EPA04952.1 - 0.0006 19.4 0.2 0.0015 18.1 0.1 1.7 1 0 0 1 1 1 1 HTH domain MarR_2 PF12802.2 EPA04952.1 - 0.0017 17.9 0.0 0.003 17.1 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.1 EPA04952.1 - 0.0024 18.1 0.0 0.0044 17.2 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain RepL PF05732.6 EPA04952.1 - 0.0051 16.0 0.1 0.01 15.0 0.1 1.5 1 0 0 1 1 1 1 Firmicute plasmid replication protein (RepL) TFIIE_alpha PF02002.12 EPA04952.1 - 0.0092 15.4 0.2 0.016 14.7 0.1 1.4 1 0 0 1 1 1 1 TFIIE alpha subunit TrmB PF01978.14 EPA04952.1 - 0.014 15.0 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Rrf2 PF02082.15 EPA04952.1 - 0.022 14.8 0.1 0.053 13.6 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator Sulfolobus_pRN PF05584.6 EPA04952.1 - 0.028 14.3 0.4 0.48 10.4 0.1 2.2 2 0 0 2 2 2 0 Sulfolobus plasmid regulatory protein HTH_34 PF13601.1 EPA04952.1 - 0.037 14.0 0.1 0.069 13.1 0.1 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_40 PF14493.1 EPA04952.1 - 0.042 14.0 0.2 0.14 12.4 0.1 1.9 1 1 1 2 2 2 0 Helix-turn-helix domain HTH_CodY PF08222.6 EPA04952.1 - 0.061 12.6 0.0 0.22 10.9 0.0 1.9 2 0 0 2 2 2 0 CodY helix-turn-helix domain GrpE PF01025.14 EPA04954.1 - 2.5e-37 128.0 2.8 2.7e-37 127.8 1.9 1.0 1 0 0 1 1 1 1 GrpE UBN2 PF14223.1 EPA04954.1 - 0.07 12.9 2.7 5 6.9 0.2 2.3 1 1 1 2 2 2 0 gag-polypeptide of LTR copia-type RPA_interact_M PF14767.1 EPA04954.1 - 0.097 13.4 0.6 3.7 8.3 0.7 2.2 1 1 1 2 2 2 0 Replication protein A interacting middle P4Ha_N PF08336.6 EPA04954.1 - 0.1 12.4 1.1 0.15 11.8 0.8 1.3 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF334 PF03904.8 EPA04954.1 - 0.33 10.2 4.9 0.49 9.6 3.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF334) HSP70 PF00012.15 EPA04955.1 - 1.2e-21 76.3 0.1 1.3e-21 76.2 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein Aminotran_5 PF00266.14 EPA04956.1 - 1.3e-151 504.5 0.4 1.5e-151 504.3 0.3 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 EPA04956.1 - 4.1e-07 29.2 0.2 3.7e-06 26.1 0.1 2.0 2 0 0 2 2 2 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EPA04956.1 - 7.6e-06 25.2 0.0 1.9e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 EPA04956.1 - 0.00038 18.8 0.0 0.00083 17.7 0.0 1.5 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF4582 PF15189.1 EPA04956.1 - 0.11 11.6 0.9 1.2 8.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4582) TPR_11 PF13414.1 EPA04958.1 - 3.6e-22 77.7 1.5 5.6e-11 41.9 0.0 2.2 1 1 2 3 3 3 3 TPR repeat TPR_1 PF00515.23 EPA04958.1 - 1e-16 59.7 1.0 3.3e-07 29.6 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 EPA04958.1 - 5.4e-15 54.0 0.4 7.2e-07 28.6 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 EPA04958.1 - 6.2e-14 52.0 0.1 4.8e-08 33.2 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 EPA04958.1 - 5.5e-12 45.4 0.1 3e-06 27.0 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 EPA04958.1 - 7.1e-12 44.5 0.3 0.0017 18.3 0.0 3.6 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 EPA04958.1 - 5.1e-11 41.5 2.5 1.6e-05 24.3 0.1 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 EPA04958.1 - 2.5e-09 37.1 0.2 3.6e-09 36.6 0.2 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 EPA04958.1 - 4.5e-09 36.1 0.0 0.02 15.5 0.0 3.0 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 EPA04958.1 - 7.4e-09 34.7 0.0 0.0042 16.7 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 EPA04958.1 - 1.4e-08 35.1 0.0 0.00072 20.1 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 EPA04958.1 - 6.7e-06 26.2 0.1 0.047 14.1 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EPA04958.1 - 5.4e-05 22.9 1.1 0.048 13.5 0.1 3.2 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat ChAPs PF09295.5 EPA04958.1 - 0.00018 20.4 0.1 0.00021 20.2 0.0 1.0 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_15 PF13429.1 EPA04958.1 - 0.00025 20.2 0.0 0.00036 19.6 0.0 1.3 1 1 0 1 1 1 1 Tetratricopeptide repeat NARP1 PF12569.3 EPA04958.1 - 0.0021 16.9 0.2 0.25 10.0 0.0 1.9 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 TPR_9 PF13371.1 EPA04958.1 - 0.0055 16.5 0.0 0.1 12.4 0.0 1.7 1 1 1 2 2 2 2 Tetratricopeptide repeat Porphobil_deam PF01379.15 EPA04959.1 - 1.1e-35 122.4 0.0 1.6e-35 121.9 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 EPA04959.1 - 4.3e-12 45.9 0.0 7.2e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain PKD PF00801.15 EPA04960.1 - 2.8e-06 26.9 34.2 0.27 11.0 0.3 8.8 7 3 0 7 7 7 5 PKD domain FokI_N PF02981.10 EPA04960.1 - 0.0045 16.5 0.1 0.71 9.4 0.0 3.3 3 0 0 3 3 3 1 Restriction endonuclease FokI, recognition domain DUF824 PF05688.6 EPA04960.1 - 2 8.0 7.7 12 5.6 0.2 4.3 5 1 0 5 5 5 0 Salmonella repeat of unknown function (DUF824) TP_methylase PF00590.15 EPA04961.1 - 2.2e-48 164.7 0.0 2.5e-48 164.5 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF2976 PF11190.3 EPA04962.1 - 0.02 14.4 1.2 0.031 13.7 0.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2976) TatC PF00902.13 EPA04962.1 - 0.039 13.3 5.6 0.044 13.1 3.9 1.1 1 0 0 1 1 1 0 Sec-independent protein translocase protein (TatC) DUF1705 PF08019.7 EPA04962.1 - 0.15 11.5 1.4 0.16 11.4 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1705) DUF4064 PF13273.1 EPA04962.1 - 0.16 12.0 3.6 0.25 11.4 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) DUF1426 PF07234.6 EPA04962.1 - 1.3 8.7 5.9 0.18 11.5 1.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1426) NfeD PF01957.13 EPA04962.1 - 6.6 6.8 6.4 41 4.2 3.5 1.9 1 1 1 2 2 2 0 NfeD-like C-terminal, partner-binding Tmemb_cc2 PF10267.4 EPA04963.1 - 0.084 11.4 0.0 0.1 11.1 0.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein HTH_Tnp_Tc5 PF03221.11 EPA04964.1 - 0.0021 17.8 0.0 0.0038 17.0 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HEM4 PF02602.10 EPA04965.1 - 4.9e-43 147.0 0.0 5.6e-43 146.8 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD PGM_PMM_II PF02879.11 EPA04965.1 - 0.14 12.4 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Gaa1 PF04114.9 EPA04966.1 - 0.13 10.9 3.0 0.15 10.7 2.1 1.0 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component ABC2_membrane PF01061.19 EPA04967.1 - 4.9e-34 117.3 18.4 4.9e-34 117.3 12.8 1.8 1 1 1 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 EPA04967.1 - 3.7e-17 62.3 30.5 4.6e-17 62.0 21.2 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.2 EPA04967.1 - 3.1e-10 39.6 24.0 4.2e-10 39.1 16.7 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.2 EPA04967.1 - 4.1e-07 29.1 22.0 7.8e-07 28.2 15.3 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein DUF1616 PF07760.6 EPA04967.1 - 0.016 14.3 8.8 0.26 10.3 6.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1616) PGK PF00162.14 EPA04968.1 - 3.7e-111 371.4 0.0 4.2e-111 371.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF218 PF02698.12 EPA04968.1 - 0.014 14.9 0.1 0.6 9.5 0.0 2.4 2 0 0 2 2 2 0 DUF218 domain CbiA PF01656.18 EPA04968.1 - 0.019 14.3 0.1 0.81 9.0 0.0 2.2 1 1 1 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF3108 PF11306.3 EPA04969.1 - 0.0096 15.6 0.2 0.021 14.4 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3108) MFS_1 PF07690.11 EPA04970.1 - 9.4e-23 80.4 34.0 3.2e-14 52.3 10.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.8 EPA04970.1 - 0.00032 18.9 6.4 0.00045 18.4 4.5 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector BIV_Env PF05858.7 EPA04970.1 - 0.18 9.7 1.0 6.8 4.5 0.3 2.0 2 0 0 2 2 2 0 Bovine immunodeficiency virus surface protein (SU) Claudin_2 PF13903.1 EPA04970.1 - 2.5 7.7 11.3 0.61 9.7 3.3 2.2 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction PRC PF05239.11 EPA04971.1 - 0.00021 21.1 0.2 0.00028 20.6 0.2 1.3 1 1 0 1 1 1 1 PRC-barrel domain DUF3945 PF13101.1 EPA04971.1 - 0.07 12.4 0.1 0.26 10.6 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3945) Metallothio PF00131.15 EPA04972.1 - 0.0086 15.9 14.4 0.0086 15.9 9.9 1.9 1 1 1 2 2 2 1 Metallothionein Noelin-1 PF12308.3 EPA04972.1 - 4.1 7.2 5.9 4.2 7.2 4.1 1.1 1 0 0 1 1 1 0 Neurogenesis glycoprotein VESA1_N PF12785.2 EPA04972.1 - 7.4 5.4 16.1 7.2 5.4 11.2 1.0 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 Aminotran_3 PF00202.16 EPA04973.1 - 2.1e-69 234.0 0.1 2.6e-69 233.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 EPA04973.1 - 2.2e-06 26.8 0.0 2.9e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II RasGAP_C PF03836.10 EPA04973.1 - 0.0081 15.8 0.3 0.019 14.6 0.2 1.6 1 0 0 1 1 1 1 RasGAP C-terminus z-alpha PF02295.12 EPA04973.1 - 0.09 12.5 0.1 0.32 10.7 0.1 1.9 1 0 0 1 1 1 0 Adenosine deaminase z-alpha domain UPF0051 PF01458.12 EPA04974.1 - 7.1e-68 228.4 1.1 8.9e-68 228.1 0.7 1.1 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) DUF2152 PF10222.4 EPA04974.1 - 0.017 13.3 0.0 0.03 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2152) DUF1059 PF06348.6 EPA04978.1 - 1.2e-18 66.6 1.0 1.3e-18 66.5 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) Transposase_22 PF02994.9 EPA04978.1 - 0.098 11.1 0.8 0.11 11.0 0.5 1.0 1 0 0 1 1 1 0 L1 transposable element Toxin_18 PF08087.6 EPA04978.1 - 0.16 11.7 0.4 0.21 11.4 0.3 1.1 1 0 0 1 1 1 0 Conotoxin O-superfamily ABC_tran PF00005.22 EPA04979.1 - 6.2e-31 107.5 0.0 1.5e-30 106.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EPA04979.1 - 7.4e-13 49.0 7.7 2.7e-09 37.4 0.1 3.0 2 1 0 3 3 3 2 AAA domain AAA_15 PF13175.1 EPA04979.1 - 1.4e-05 24.3 9.6 2e-05 23.8 0.2 3.1 3 0 0 3 3 3 1 AAA ATPase domain DUF4162 PF13732.1 EPA04979.1 - 0.00014 22.3 1.7 0.00031 21.1 1.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_29 PF13555.1 EPA04979.1 - 0.00037 19.9 0.3 0.00072 19.0 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 EPA04979.1 - 0.0017 18.7 9.3 0.016 15.5 6.5 2.5 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 EPA04979.1 - 0.0055 15.9 1.9 0.045 12.9 0.4 2.4 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 EPA04979.1 - 0.014 14.5 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SRP54 PF00448.17 EPA04979.1 - 0.02 14.3 0.2 0.048 13.0 0.0 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MobB PF03205.9 EPA04979.1 - 0.097 12.3 0.1 0.21 11.2 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 EPA04979.1 - 0.22 11.4 2.1 2.6 8.0 1.4 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF385 PF04075.9 EPA04980.1 - 0.0011 18.9 0.0 0.0013 18.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF385) DUF2255 PF10012.4 EPA04980.1 - 0.08 12.9 0.1 0.092 12.7 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2255) PRC PF05239.11 EPA04981.1 - 0.00031 20.5 0.0 0.0004 20.1 0.0 1.1 1 0 0 1 1 1 1 PRC-barrel domain COX1 PF00115.15 EPA04982.1 - 0.03 12.9 0.1 0.031 12.9 0.1 1.1 1 0 0 1 1 1 0 Cytochrome C and Quinol oxidase polypeptide I E1-E2_ATPase PF00122.15 EPA04982.1 - 0.078 11.9 2.2 0.084 11.9 1.5 1.0 1 0 0 1 1 1 0 E1-E2 ATPase PsbX PF06596.6 EPA04982.1 - 0.15 11.7 0.6 0.15 11.7 0.4 1.8 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) DUF131 PF01998.12 EPA04982.1 - 1.5 8.2 5.2 0.95 8.8 2.6 1.4 1 1 0 1 1 1 0 Protein of unknown function DUF131 MIP PF00230.15 EPA04985.1 - 4.7e-39 134.1 19.9 5.6e-39 133.9 13.8 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF2105 PF09878.4 EPA04985.1 - 1.5 8.3 12.8 0.039 13.5 3.7 2.0 1 1 0 2 2 2 0 Predicted membrane protein (DUF2105) Rieske PF00355.21 EPA04986.1 - 6.7e-19 67.2 0.0 7.5e-19 67.1 0.0 1.0 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 EPA04986.1 - 1.8e-13 50.0 0.0 2e-13 49.9 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain DUF1504 PF07399.6 EPA04987.1 - 0.028 13.0 1.6 0.034 12.8 1.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1504) BCCT PF02028.12 EPA04987.1 - 0.044 12.0 1.5 0.076 11.2 0.0 2.0 1 1 0 2 2 2 0 BCCT family transporter LHC PF00556.15 EPA04987.1 - 0.23 11.3 0.4 0.23 11.3 0.3 2.1 3 0 0 3 3 3 0 Antenna complex alpha/beta subunit PAP2 PF01569.16 EPA04987.1 - 0.26 10.9 1.2 2.2 7.9 0.0 2.5 1 1 2 3 3 3 0 PAP2 superfamily ABC2_membrane_4 PF12730.2 EPA04987.1 - 0.4 9.8 5.7 0.56 9.3 3.9 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF998 PF06197.8 EPA04987.1 - 0.65 9.2 2.9 0.76 9.0 0.2 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF998) O-antigen_lig PF13425.1 EPA04987.1 - 4 7.4 8.4 5.2 7.0 2.2 2.0 1 1 1 2 2 2 0 O-antigen ligase like membrane protein SdpI PF13630.1 EPA04987.1 - 4.9 6.9 6.9 4.7 7.0 1.4 2.1 2 0 0 2 2 2 0 SdpI/YhfL protein family NifU_N PF01592.11 EPA04988.1 - 5.4e-29 100.7 0.0 6.3e-29 100.4 0.0 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain Ste50p-SAM PF09235.5 EPA04988.1 - 0.072 13.1 0.8 0.77 9.8 0.0 2.3 2 0 0 2 2 2 0 Ste50p, sterile alpha motif DUF836 PF05768.9 EPA04988.1 - 0.14 12.4 0.7 0.22 11.8 0.3 1.6 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) UPF0051 PF01458.12 EPA04990.1 - 1.7e-69 233.8 0.2 2.2e-69 233.4 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) HEAT_2 PF13646.1 EPA04992.1 - 8e-10 38.8 0.0 2.4e-06 27.7 0.0 2.3 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.17 EPA04992.1 - 0.004 17.1 0.0 1.4 9.1 0.0 3.1 3 0 0 3 3 3 1 HEAT repeat Cnd1 PF12717.2 EPA04992.1 - 0.026 14.3 0.0 0.043 13.6 0.0 1.6 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 EPA04992.1 - 0.062 12.6 0.0 0.15 11.3 0.0 1.6 1 1 0 1 1 1 0 CLASP N terminal TrmB PF01978.14 EPA04993.1 - 0.0018 17.9 0.0 0.0053 16.4 0.0 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Redoxin PF08534.5 EPA04994.1 - 4.8e-08 32.6 0.1 2.6e-05 23.8 0.0 2.2 1 1 1 2 2 2 2 Redoxin AhpC-TSA PF00578.16 EPA04994.1 - 1.4e-07 31.2 0.2 1.7e-06 27.7 0.1 2.3 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.1 EPA04994.1 - 7.1e-05 22.9 0.2 0.0011 19.1 0.2 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EPA04994.1 - 0.00034 20.6 0.1 0.75 9.9 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin-like Neur_chan_memb PF02932.11 EPA04995.1 - 1.4e-06 28.4 3.0 2.5e-06 27.5 2.1 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region 60KD_IMP PF02096.15 EPA04995.1 - 0.77 9.3 4.8 1.3 8.6 3.3 1.3 1 0 0 1 1 1 0 60Kd inner membrane protein Cu-binding_MopE PF11617.3 EPA04996.1 - 4.4e-21 74.3 23.4 2.3e-11 43.2 3.2 3.1 3 0 0 3 3 3 2 Protein metal binding site FlaE PF07559.9 EPA04996.1 - 0.17 12.5 4.0 1.8 9.2 0.8 2.1 1 1 1 2 2 2 0 Flagellar basal body protein FlaE SNase PF00565.12 EPA04997.1 - 8.4e-08 32.4 0.0 1.2e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue ABC_tran PF00005.22 EPA04998.1 - 2.8e-19 69.7 0.5 7e-19 68.4 0.3 1.6 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EPA04998.1 - 1e-06 28.9 1.6 0.008 16.1 0.0 2.7 2 1 1 3 3 3 2 AAA domain AAA_15 PF13175.1 EPA04998.1 - 0.00034 19.7 1.0 0.32 9.9 0.0 2.2 1 1 1 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 EPA04998.1 - 0.0012 18.0 1.4 0.0029 16.8 0.9 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Miro PF08477.8 EPA04998.1 - 0.015 15.7 0.1 0.05 14.1 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein Met_10 PF02475.11 EPA04999.1 - 1.6e-49 168.2 0.1 1.8e-49 168.0 0.1 1.0 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.8 EPA04999.1 - 9.3e-05 21.6 0.1 0.00018 20.7 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 EPA04999.1 - 0.00038 20.4 0.0 0.0006 19.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EPA04999.1 - 0.0025 17.1 0.0 0.0041 16.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 EPA04999.1 - 0.0039 17.7 0.0 0.0069 16.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.21 EPA04999.1 - 0.018 14.6 0.0 0.09 12.3 0.0 2.0 3 0 0 3 3 3 0 Zinc-binding dehydrogenase Methyltransf_15 PF09445.5 EPA04999.1 - 0.018 14.6 0.1 0.035 13.6 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_16 PF10294.4 EPA04999.1 - 0.03 13.7 0.0 0.042 13.3 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_31 PF13847.1 EPA04999.1 - 0.039 13.5 0.1 0.087 12.4 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain DNA_methylase PF00145.12 EPA04999.1 - 0.045 12.8 0.0 0.075 12.1 0.0 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase T2SE PF00437.15 EPA05001.1 - 5.4e-50 169.8 0.0 8.6e-50 169.1 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.1 EPA05001.1 - 0.00033 20.1 0.0 0.00073 19.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 EPA05001.1 - 0.00053 19.5 0.0 0.0013 18.2 0.0 1.6 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_17 PF13207.1 EPA05001.1 - 0.00094 19.9 0.0 0.0031 18.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EPA05001.1 - 0.0031 17.7 0.7 0.014 15.6 0.0 2.3 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.22 EPA05001.1 - 0.01 16.1 0.1 0.082 13.2 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_19 PF13245.1 EPA05001.1 - 0.027 14.2 0.1 0.06 13.1 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain Zeta_toxin PF06414.7 EPA05001.1 - 0.042 12.9 0.0 0.074 12.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin TrwB_AAD_bind PF10412.4 EPA05001.1 - 0.055 12.0 0.0 0.14 10.7 0.0 1.6 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.1 EPA05001.1 - 0.081 12.4 0.2 0.18 11.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain DUF3104 PF11302.3 EPA05001.1 - 0.11 11.8 0.0 2.1 7.7 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3104) GalP_UDP_transf PF01087.17 EPA05002.1 - 1.2e-10 41.7 0.0 5e-10 39.7 0.0 1.9 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain HIT PF01230.18 EPA05002.1 - 0.00012 22.5 0.0 0.02 15.4 0.0 2.3 2 0 0 2 2 2 1 HIT domain GalP_UDP_tr_C PF02744.12 EPA05002.1 - 0.0021 17.6 0.0 0.0037 16.8 0.0 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DcpS_C PF11969.3 EPA05002.1 - 0.0083 16.3 0.0 0.055 13.6 0.0 2.1 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding NTP_transferase PF00483.18 EPA05003.1 - 1.8e-37 128.9 0.0 2e-37 128.8 0.0 1.0 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 EPA05003.1 - 1.5e-09 38.1 0.0 1.8e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.14 EPA05003.1 - 0.058 12.9 0.0 0.12 11.8 0.0 1.5 2 0 0 2 2 2 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Ribosomal_S24e PF01282.14 EPA05004.1 - 5.6e-05 22.8 0.3 7.7e-05 22.4 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S24e GXGXG PF01493.14 EPA05004.1 - 0.0095 14.9 0.0 0.012 14.6 0.0 1.1 1 0 0 1 1 1 1 GXGXG motif DUF309 PF03745.9 EPA05005.1 - 4.4e-17 61.2 0.1 6.6e-17 60.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF309) SprT-like PF10263.4 EPA05006.1 - 0.033 13.8 0.0 0.049 13.2 0.0 1.3 1 0 0 1 1 1 0 SprT-like family GAS PF13851.1 EPA05006.1 - 0.034 13.3 0.9 0.053 12.7 0.6 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Ribosomal_S27 PF01599.14 EPA05008.1 - 8.5e-19 67.1 5.6 1e-18 66.8 3.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S27a GCC2_GCC3 PF07699.8 EPA05008.1 - 0.00071 19.0 2.0 0.0011 18.5 1.4 1.2 1 0 0 1 1 1 1 GCC2 and GCC3 DUF1451 PF07295.6 EPA05008.1 - 0.0013 18.5 0.6 0.0013 18.5 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1451) DZR PF12773.2 EPA05008.1 - 0.0044 16.7 0.6 0.0059 16.4 0.4 1.3 1 0 0 1 1 1 1 Double zinc ribbon A2L_zn_ribbon PF08792.5 EPA05008.1 - 0.0068 15.8 2.2 0.011 15.1 1.5 1.2 1 0 0 1 1 1 1 A2L zinc ribbon domain Ribosomal_L37e PF01907.14 EPA05008.1 - 0.013 15.2 3.6 0.021 14.5 2.5 1.3 1 0 0 1 1 1 0 Ribosomal protein L37e GFA PF04828.9 EPA05008.1 - 0.031 14.2 2.5 0.081 12.8 0.1 1.9 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_2 PF13240.1 EPA05008.1 - 0.036 13.5 2.6 1.8 8.1 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain NCD3G PF07562.9 EPA05008.1 - 0.039 13.6 0.6 0.05 13.3 0.4 1.2 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR C1_1 PF00130.17 EPA05008.1 - 0.048 13.4 1.3 0.065 12.9 0.9 1.1 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) SprT-like PF10263.4 EPA05008.1 - 0.079 12.6 0.5 0.077 12.6 0.3 1.0 1 0 0 1 1 1 0 SprT-like family HypA PF01155.14 EPA05008.1 - 0.11 12.2 0.6 0.11 12.1 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-ribbon_3 PF13248.1 EPA05008.1 - 0.15 11.2 5.6 0.84 8.9 0.3 2.1 1 1 1 2 2 2 0 zinc-ribbon domain DNA_RNApol_7kD PF03604.8 EPA05008.1 - 0.22 11.0 3.2 0.39 10.2 2.2 1.4 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit OrfB_Zn_ribbon PF07282.6 EPA05008.1 - 0.29 10.8 3.8 0.43 10.2 2.6 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Nudix_N_2 PF14803.1 EPA05008.1 - 0.69 9.6 6.8 6.2 6.6 3.7 2.3 1 1 1 2 2 2 0 Nudix N-terminal zf-C2H2_3 PF13878.1 EPA05008.1 - 0.78 9.3 6.1 3.7 7.1 0.5 2.2 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO Acetyltransf_1 PF00583.19 EPA05010.1 - 1.4e-16 60.2 0.0 2.4e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EPA05010.1 - 3.5e-15 55.9 0.0 5.7e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EPA05010.1 - 2.1e-08 34.0 0.0 2.5e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EPA05010.1 - 3.8e-07 30.2 0.0 4.6e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EPA05010.1 - 6.3e-06 26.2 0.1 8.6e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EPA05010.1 - 0.0018 18.0 0.0 0.08 12.7 0.0 2.4 2 1 0 2 2 2 1 FR47-like protein PAZ_siRNAbind PF12212.3 EPA05010.1 - 0.0031 17.1 0.0 0.009 15.6 0.0 1.8 1 0 0 1 1 1 1 Piwi/Argonaute/Zwille siRNA-binding domain Acetyltransf_CG PF14542.1 EPA05010.1 - 0.0065 16.3 0.0 0.0089 15.8 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase SH2_2 PF14633.1 EPA05010.1 - 0.075 12.0 0.1 0.13 11.2 0.1 1.4 1 0 0 1 1 1 0 SH2 domain Acetyltransf_8 PF13523.1 EPA05010.1 - 0.079 12.8 0.0 0.2 11.5 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain PhosphMutase PF10143.4 EPA05011.1 - 1.3e-48 164.8 0.0 2.1e-48 164.1 0.0 1.4 1 0 0 1 1 1 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Metalloenzyme PF01676.13 EPA05011.1 - 1.2e-31 110.0 1.5 1.9e-31 109.3 1.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.17 EPA05011.1 - 0.00036 19.9 0.0 0.0041 16.5 0.0 2.2 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase MFS_1 PF07690.11 EPA05012.1 - 2.5e-05 23.1 8.7 3.4e-05 22.7 6.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Oxidored_q2 PF00420.19 EPA05012.1 - 0.1 12.1 0.1 0.1 12.1 0.1 2.2 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF956 PF06115.6 EPA05012.1 - 0.12 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF956) IncFII_repA PF02387.10 EPA05012.1 - 0.2 10.7 0.3 0.26 10.4 0.2 1.1 1 0 0 1 1 1 0 IncFII RepA protein family MFS_2 PF13347.1 EPA05012.1 - 0.68 8.2 11.2 0.93 7.8 7.6 1.3 1 1 0 1 1 1 0 MFS/sugar transport protein Claudin_2 PF13903.1 EPA05012.1 - 0.78 9.4 4.2 0.64 9.6 1.8 1.6 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction YesK PF14150.1 EPA05012.1 - 2.3 8.3 9.3 0.28 11.3 0.4 2.8 2 1 0 3 3 3 0 YesK-like protein DUF2189 PF09955.4 EPA05012.1 - 6.5 6.7 10.3 17 5.3 6.3 2.2 1 1 0 1 1 1 0 Predicted integral membrane protein (DUF2189) DUF2975 PF11188.3 EPA05012.1 - 6.8 6.4 11.8 3.6 7.2 2.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) 7TMR-DISM_7TM PF07695.6 EPA05012.1 - 7.1 6.2 12.7 19 4.8 8.9 1.7 1 1 0 1 1 1 0 7TM diverse intracellular signalling GNVR PF13807.1 EPA05013.1 - 0.017 14.8 0.1 0.018 14.7 0.1 1.0 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase Pyridox_ox_2 PF12900.2 EPA05014.1 - 1e-07 31.9 0.0 1.2e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxidase PF01243.15 EPA05014.1 - 3.3e-07 30.2 0.0 5e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF1722 PF08349.6 EPA05015.1 - 8.7e-35 119.1 2.3 1.3e-34 118.5 1.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1722) DUF2420 PF10336.4 EPA05015.1 - 0.0072 15.9 0.9 0.0099 15.4 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) DNA_photolyase PF00875.13 EPA05016.1 - 5.5e-28 97.7 0.0 6e-28 97.6 0.0 1.0 1 0 0 1 1 1 1 DNA photolyase FAD_binding_7 PF03441.9 EPA05017.1 - 1.4e-95 319.6 2.0 1.8e-95 319.3 1.4 1.1 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase OprF PF05736.6 EPA05017.1 - 0.0046 16.4 0.0 0.0082 15.6 0.0 1.4 1 0 0 1 1 1 1 OprF membrane domain DNA_primase_S PF01896.14 EPA05017.1 - 0.011 15.6 0.1 0.057 13.2 0.1 1.9 1 1 0 1 1 1 0 Eukaryotic and archaeal DNA primase small subunit DUF3440 PF11922.3 EPA05017.1 - 0.073 12.6 3.3 0.31 10.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3440) HD PF01966.17 EPA05019.1 - 8.4e-17 61.3 0.1 1.2e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 HD domain CesA PF11439.3 EPA05019.1 - 0.022 14.6 0.2 0.059 13.2 0.2 1.7 1 0 0 1 1 1 0 Type III secretion system filament chaperone CesA ClpS PF02617.12 EPA05019.1 - 0.034 13.8 0.1 0.082 12.6 0.1 1.6 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS Amino_oxidase PF01593.19 EPA05020.1 - 4.4e-12 45.8 0.0 8.6e-12 44.8 0.0 1.5 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 EPA05020.1 - 1.1e-11 44.5 0.0 2.1e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EPA05020.1 - 6.9e-08 31.7 0.0 0.0067 15.3 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EPA05020.1 - 0.00024 20.0 0.4 0.015 14.1 0.5 2.1 2 0 0 2 2 2 1 FAD binding domain GDI PF00996.13 EPA05020.1 - 0.00041 18.7 0.7 0.021 13.1 0.1 2.1 2 0 0 2 2 2 1 GDP dissociation inhibitor Pyr_redox PF00070.22 EPA05020.1 - 0.00074 19.8 1.2 0.044 14.1 0.0 2.7 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EPA05020.1 - 0.0013 17.8 0.1 0.002 17.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 EPA05020.1 - 0.0017 17.5 1.8 0.033 13.2 0.1 2.5 3 0 0 3 3 3 1 Thi4 family Pyr_redox_3 PF13738.1 EPA05020.1 - 0.0022 18.0 0.1 0.44 10.5 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EPA05020.1 - 0.0043 15.5 0.2 0.82 8.0 0.2 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.9 EPA05020.1 - 0.013 15.4 0.1 0.036 13.9 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.9 EPA05020.1 - 0.029 13.7 2.1 0.031 13.6 0.2 2.0 3 0 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_oxidored PF12831.2 EPA05020.1 - 0.041 12.9 0.0 0.44 9.5 0.0 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.17 EPA05020.1 - 0.054 12.3 1.1 2.3 6.9 0.1 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A zf-FCS PF06467.9 EPA05023.1 - 0.35 10.5 6.7 2.4 7.8 0.3 2.2 1 1 1 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-CCHC_4 PF14392.1 EPA05023.1 - 1.6 8.4 6.8 0.08 12.6 1.2 1.6 1 1 1 2 2 2 0 Zinc knuckle TF_Zn_Ribbon PF08271.7 EPA05024.1 - 7.3e-06 25.2 0.3 1.6e-05 24.0 0.2 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Ribosomal_S27e PF01667.12 EPA05024.1 - 0.053 13.0 1.1 0.2 11.2 0.1 2.0 2 0 0 2 2 2 0 Ribosomal protein S27 DUF1610 PF07754.6 EPA05024.1 - 0.085 12.9 5.3 0.4 10.8 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) TFIIB PF00382.14 EPA05025.1 - 1.3e-23 82.5 2.8 8.1e-13 47.9 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Rrf2 PF02082.15 EPA05025.1 - 0.00035 20.6 0.7 0.44 10.6 0.0 2.8 2 1 1 3 3 3 2 Transcriptional regulator Cyclin_C PF02984.14 EPA05025.1 - 0.0057 16.5 0.0 0.013 15.3 0.0 1.6 2 0 0 2 2 2 1 Cyclin, C-terminal domain CbiD PF01888.12 EPA05025.1 - 0.025 13.5 0.2 0.034 13.1 0.2 1.2 1 0 0 1 1 1 0 CbiD HTH_24 PF13412.1 EPA05025.1 - 0.027 13.8 0.6 0.22 10.9 0.1 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding NAD_binding_10 PF13460.1 EPA05026.1 - 1.1e-21 77.7 0.0 1.4e-21 77.3 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EPA05026.1 - 5.2e-12 45.6 0.0 4e-10 39.5 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 EPA05026.1 - 8.3e-12 44.8 0.0 1.1e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.14 EPA05026.1 - 6.6e-10 38.1 0.0 1.4e-09 37.0 0.0 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EPA05026.1 - 0.0021 17.0 0.0 0.0042 16.0 0.0 1.4 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 EPA05026.1 - 0.0022 16.9 0.7 0.013 14.4 0.1 2.4 2 1 0 2 2 2 1 Male sterility protein Saccharop_dh PF03435.13 EPA05026.1 - 0.019 13.9 0.0 0.028 13.3 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Polysacc_synt_2 PF02719.10 EPA05026.1 - 0.038 12.8 0.8 0.22 10.3 0.6 2.0 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Lar_restr_allev PF14354.1 EPA05027.1 - 0.016 15.5 0.4 0.018 15.3 0.3 1.1 1 0 0 1 1 1 0 Restriction alleviation protein Lar Zn_Tnp_IS1595 PF12760.2 EPA05027.1 - 0.044 13.6 0.6 0.063 13.0 0.4 1.2 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-DNA_Pol PF08996.5 EPA05027.1 - 0.076 12.3 0.9 0.09 12.1 0.6 1.0 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger TF_Zn_Ribbon PF08271.7 EPA05027.1 - 0.14 11.4 1.5 3.3 7.0 0.1 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding zf-RING_3 PF14369.1 EPA05027.1 - 0.2 11.6 1.3 7.6 6.6 0.1 2.2 2 0 0 2 2 2 0 zinc-finger DUF3716 PF12511.3 EPA05027.1 - 0.52 9.9 3.1 0.77 9.4 2.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3716) zf-CCHC PF00098.18 EPA05027.1 - 4.4 7.4 6.3 0.99 9.4 1.2 2.0 2 0 0 2 2 2 0 Zinc knuckle zinc_ribbon_5 PF13719.1 EPA05027.1 - 4.9 6.8 6.2 2.4 7.8 0.5 2.1 2 0 0 2 2 2 0 zinc-ribbon domain B12-binding_2 PF02607.12 EPA05028.1 - 3.3e-13 49.4 0.0 5.6e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 B12 binding domain B12-binding PF02310.14 EPA05028.1 - 2.1e-12 46.9 0.0 3.6e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 B12 binding domain Polysacc_deac_1 PF01522.16 EPA05029.1 - 0.00033 20.2 0.0 0.0006 19.4 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Ribosomal_L7Ae PF01248.21 EPA05030.1 - 4.4e-12 45.3 0.5 5.4e-12 45.0 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF1694 PF07997.6 EPA05030.1 - 0.025 14.5 1.1 0.043 13.7 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) NAD_binding_2 PF03446.10 EPA05030.1 - 0.15 11.8 0.3 0.21 11.4 0.2 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Ribosomal_S7 PF00177.16 EPA05031.1 - 8.9e-38 129.1 0.8 1.3e-37 128.6 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Ribosom_S12_S23 PF00164.20 EPA05032.1 - 2e-38 130.5 0.3 2.3e-38 130.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 TPR_11 PF13414.1 EPA05033.1 - 1.4e-20 72.6 0.4 1.5e-10 40.5 0.0 2.3 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 EPA05033.1 - 1.9e-20 71.5 0.7 8.3e-08 31.5 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 EPA05033.1 - 1.8e-17 61.7 0.0 1.3e-05 24.7 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 EPA05033.1 - 2.4e-13 49.1 2.2 0.0013 18.7 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 EPA05033.1 - 2.6e-10 39.3 6.9 0.00036 20.0 0.0 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 EPA05033.1 - 7.6e-10 38.5 0.1 1.2e-07 31.5 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 EPA05033.1 - 4.9e-09 36.6 0.0 0.00021 21.8 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 EPA05033.1 - 1.7e-08 33.6 0.0 0.0029 17.2 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 EPA05033.1 - 1.4e-06 28.4 0.0 0.023 15.0 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 EPA05033.1 - 3.9e-06 27.0 0.0 0.13 12.9 0.0 3.2 1 1 2 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EPA05033.1 - 3.9e-05 23.4 0.1 1.1 9.1 0.0 3.3 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 EPA05033.1 - 0.0026 18.1 0.3 0.38 11.3 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.3 EPA05033.1 - 0.0031 16.3 0.0 0.16 10.6 0.0 2.1 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 TPR_9 PF13371.1 EPA05033.1 - 0.032 14.0 0.0 0.4 10.5 0.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.2 EPA05033.1 - 0.038 13.8 0.0 4.3 7.1 0.0 2.7 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) TPR_10 PF13374.1 EPA05033.1 - 0.11 12.4 0.0 0.66 9.9 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat KH_2 PF07650.12 EPA05034.1 - 3e-19 68.3 2.8 6.1e-13 48.1 0.1 2.1 1 1 1 2 2 2 2 KH domain KH_4 PF13083.1 EPA05034.1 - 3.8e-11 42.4 0.5 1.5e-05 24.5 0.1 2.2 2 0 0 2 2 2 2 KH domain KH_5 PF13184.1 EPA05034.1 - 8e-07 28.7 2.8 3.3e-06 26.7 0.2 2.1 2 0 0 2 2 2 1 NusA-like KH domain KH_1 PF00013.24 EPA05034.1 - 2.2e-05 24.0 1.8 0.011 15.3 0.1 2.5 2 0 0 2 2 2 2 KH domain DUF3979 PF13141.1 EPA05034.1 - 0.048 13.5 0.0 0.071 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3979) DUF310 PF03750.8 EPA05034.1 - 0.057 13.5 0.1 0.083 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF310) tRNA-synt_2c PF01411.14 EPA05036.1 - 3.5e-82 276.4 0.0 3.5e-82 276.4 0.0 2.0 2 1 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 EPA05036.1 - 3.5e-15 55.6 0.8 1.1e-14 54.0 0.6 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.14 EPA05036.1 - 2.6e-07 30.2 4.4 5.7e-07 29.1 3.0 1.6 1 0 0 1 1 1 1 DHHA1 domain Slu7 PF11708.3 EPA05036.1 - 0.02 14.6 2.1 0.046 13.4 1.4 1.5 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor ATP-synt_E PF05680.7 EPA05036.1 - 8.4 6.4 9.7 2.7 7.9 4.3 2.0 2 0 0 2 2 2 0 ATP synthase E chain Peripla_BP_5 PF13433.1 EPA05038.1 - 1.4e-151 504.4 0.0 1.6e-151 504.1 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_6 PF13458.1 EPA05038.1 - 1.4e-95 320.5 0.0 1.7e-95 320.3 0.0 1.0 1 0 0 1 1 1 1 Periplasmic binding protein ANF_receptor PF01094.23 EPA05038.1 - 1.4e-09 37.2 0.0 3.7e-09 35.8 0.0 1.6 1 1 0 1 1 1 1 Receptor family ligand binding region HATPase_c PF02518.21 EPA05040.1 - 9.1e-20 70.4 1.5 1.7e-19 69.5 0.4 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.1 EPA05040.1 - 1.6e-19 70.2 0.0 3.9e-18 65.7 0.0 2.8 2 0 0 2 2 2 1 PAS domain HAMP PF00672.20 EPA05040.1 - 9.1e-12 44.9 0.0 3.1e-11 43.2 0.0 2.0 1 0 0 1 1 1 1 HAMP domain PAS_3 PF08447.6 EPA05040.1 - 1e-10 41.5 0.1 2.2e-10 40.4 0.1 1.6 1 0 0 1 1 1 1 PAS fold PAS PF00989.19 EPA05040.1 - 2e-10 40.4 0.0 4.4e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 PAS fold HATPase_c_5 PF14501.1 EPA05040.1 - 1.6e-09 37.3 0.3 7.8e-09 35.1 0.1 2.3 2 0 0 2 2 2 1 GHKL domain HisKA PF00512.20 EPA05040.1 - 2.5e-09 36.9 0.2 7.7e-09 35.4 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.5 EPA05040.1 - 3.5e-05 23.7 0.0 7.4e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.1 EPA05040.1 - 0.0013 18.4 0.2 0.017 14.7 0.0 2.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_8 PF13188.1 EPA05040.1 - 0.0044 16.8 0.0 0.028 14.2 0.0 2.3 2 0 0 2 2 2 1 PAS domain HATPase_c_2 PF13581.1 EPA05040.1 - 0.051 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain tRNA-synt_1g PF09334.6 EPA05041.1 - 1.6e-14 53.4 0.1 1.6e-14 53.4 0.0 1.3 2 0 0 2 2 2 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 EPA05041.1 - 3.7e-08 31.8 0.1 4.2e-08 31.6 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 EPA05041.1 - 0.00081 18.5 0.0 0.00091 18.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.14 EPA05041.1 - 0.0025 16.6 0.0 0.0028 16.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) Syntaxin-6_N PF09177.6 EPA05042.1 - 0.18 12.1 2.4 0.33 11.3 1.6 1.7 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF3557 PF12078.3 EPA05042.1 - 0.48 10.1 3.7 0.6 9.8 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3557) RimK PF08443.6 EPA05043.1 - 2.9e-45 154.0 0.0 3.9e-45 153.6 0.0 1.1 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_4 PF13535.1 EPA05043.1 - 8e-15 55.0 0.0 1.9e-14 53.7 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain GSH-S_ATP PF02955.11 EPA05043.1 - 7.3e-13 48.0 0.0 9.6e-13 47.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATPgrasp_Ter PF15632.1 EPA05043.1 - 1.4e-09 37.2 0.0 2.2e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 EPA05043.1 - 2.7e-08 33.8 0.1 1.3e-07 31.6 0.1 1.9 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.17 EPA05043.1 - 1.7e-06 27.5 0.0 1.4e-05 24.5 0.0 2.3 2 1 0 2 2 2 1 ATP-grasp domain ATPgrasp_YheCD PF14398.1 EPA05043.1 - 7e-06 25.0 0.0 0.0039 16.0 0.0 2.1 2 0 0 2 2 2 2 YheC/D like ATP-grasp GARS_A PF01071.14 EPA05043.1 - 0.0002 21.0 0.0 0.00033 20.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain CPSase_L_D2 PF02786.12 EPA05043.1 - 0.00026 20.3 0.0 0.0012 18.1 0.0 2.0 3 0 0 3 3 3 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.8 EPA05043.1 - 0.00046 19.6 0.0 0.33 10.3 0.0 2.8 2 1 1 3 3 3 2 D-ala D-ala ligase C-terminus ATP-grasp_5 PF13549.1 EPA05043.1 - 0.031 13.4 0.0 0.061 12.5 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_2 PF08442.5 EPA05043.1 - 0.056 12.8 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain S-methyl_trans PF02574.11 EPA05044.1 - 3.9e-70 236.5 0.0 4.4e-70 236.3 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase KNTase_C PF07827.6 EPA05044.1 - 0.027 14.2 0.0 1.3 8.7 0.0 2.7 3 0 0 3 3 3 0 KNTase C-terminal domain ECH PF00378.15 EPA05045.1 - 5.1e-73 245.2 1.8 5.8e-73 245.0 1.3 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 EPA05045.1 - 0.0018 18.4 0.2 0.0032 17.6 0.1 1.4 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region DUF3906 PF13046.1 EPA05045.1 - 0.12 12.0 0.2 0.93 9.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3906) CTP_transf_2 PF01467.21 EPA05047.1 - 2.7e-13 50.2 0.0 4.3e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase Period_C PF12114.3 EPA05047.1 - 0.041 13.4 1.1 0.076 12.6 0.1 1.8 2 0 0 2 2 2 0 Period protein 2/3C-terminal region FAD_syn PF06574.7 EPA05047.1 - 0.043 13.4 0.2 0.24 10.9 0.1 2.0 1 1 1 2 2 2 0 FAD synthetase Arginosuc_synth PF00764.14 EPA05048.1 - 8.8e-153 508.9 0.4 1e-152 508.7 0.3 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.16 EPA05048.1 - 0.019 14.4 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase HMGL-like PF00682.14 EPA05049.1 - 1.2e-61 208.4 0.0 1.6e-61 207.9 0.0 1.1 1 0 0 1 1 1 1 HMGL-like TP_methylase PF00590.15 EPA05050.1 - 5.1e-20 72.0 0.0 3e-19 69.5 0.0 1.9 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF357 PF04010.8 EPA05050.1 - 7.9e-11 41.5 0.3 8.5e-10 38.1 0.2 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF357) Ala_racemase_C PF00842.16 EPA05050.1 - 0.036 13.4 0.0 0.12 11.8 0.0 1.8 2 0 0 2 2 2 0 Alanine racemase, C-terminal domain NMT1_2 PF13379.1 EPA05051.1 - 7.4e-28 97.6 0.0 1e-27 97.1 0.0 1.1 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.6 EPA05051.1 - 2.4e-19 69.8 0.0 3e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.2 EPA05051.1 - 2.2e-08 33.7 0.0 3.3e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.15 EPA05051.1 - 7e-06 25.4 0.0 0.00053 19.3 0.0 2.1 1 1 1 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 OpuAC PF04069.7 EPA05051.1 - 7.1e-05 22.2 0.0 9.9e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Substrate binding domain of ABC-type glycine betaine transport system SBP_bac_7 PF03480.8 EPA05051.1 - 0.015 14.4 0.0 0.1 11.6 0.0 2.3 1 1 1 2 2 2 0 Bacterial extracellular solute-binding protein, family 7 Toprim_4 PF13662.1 EPA05052.1 - 1.3e-06 28.3 0.3 2.7e-06 27.2 0.2 1.6 1 0 0 1 1 1 1 Toprim domain Toprim PF01751.17 EPA05052.1 - 0.027 14.4 0.4 0.078 12.9 0.2 1.9 1 1 0 1 1 1 0 Toprim domain Toprim_2 PF13155.1 EPA05052.1 - 0.033 14.5 0.0 0.062 13.6 0.0 1.5 1 0 0 1 1 1 0 Toprim-like Copper-fist PF00649.13 EPA05052.1 - 0.18 11.0 0.0 0.39 9.9 0.0 1.5 1 0 0 1 1 1 0 Copper fist DNA binding domain zinc_ribbon_5 PF13719.1 EPA05053.1 - 7.8e-07 28.5 3.6 0.00061 19.3 0.8 2.0 1 1 1 2 2 2 2 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA05053.1 - 2.3e-06 27.1 4.3 0.0012 18.4 1.2 2.1 1 1 1 2 2 2 2 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.7 EPA05053.1 - 0.00015 21.4 6.9 0.0038 16.9 2.5 2.0 1 1 1 2 2 2 2 PhnA Zinc-Ribbon zf-ribbon_3 PF13248.1 EPA05053.1 - 0.00062 18.8 0.6 0.02 14.1 0.1 2.1 2 0 0 2 2 2 1 zinc-ribbon domain Prok-RING_1 PF14446.1 EPA05053.1 - 0.00062 19.4 2.0 0.0013 18.4 1.4 1.5 1 1 0 1 1 1 1 Prokaryotic RING finger family 1 TF_Zn_Ribbon PF08271.7 EPA05053.1 - 0.001 18.3 1.1 0.0013 18.0 0.8 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding zf-C4_Topoisom PF01396.14 EPA05053.1 - 0.001 18.5 0.7 0.11 11.9 0.0 2.1 2 0 0 2 2 2 1 Topoisomerase DNA binding C4 zinc finger zf-RING_3 PF14369.1 EPA05053.1 - 0.001 19.0 0.9 0.0015 18.5 0.6 1.2 1 0 0 1 1 1 1 zinc-finger UPF0547 PF10571.4 EPA05053.1 - 0.0016 18.0 1.8 0.46 10.2 0.1 2.1 2 0 0 2 2 2 2 Uncharacterised protein family UPF0547 zf-HYPF PF07503.7 EPA05053.1 - 0.0019 17.5 2.0 0.018 14.4 1.4 2.0 1 1 0 1 1 1 1 HypF finger DNA_RNApol_7kD PF03604.8 EPA05053.1 - 0.0033 16.8 3.2 0.011 15.2 2.2 1.8 1 1 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.14 EPA05053.1 - 0.0061 16.2 0.4 0.0066 16.1 0.3 1.1 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family Zn-ribbon_8 PF09723.5 EPA05053.1 - 0.0064 16.4 2.0 0.0091 15.9 1.4 1.3 1 0 0 1 1 1 1 Zinc ribbon domain DZR PF12773.2 EPA05053.1 - 0.011 15.5 1.2 0.021 14.6 0.8 1.5 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.1 EPA05053.1 - 0.024 14.1 3.0 0.77 9.3 2.1 2.2 1 1 0 1 1 1 0 zinc-ribbon domain zf-CSL PF05207.8 EPA05053.1 - 0.031 13.8 1.0 0.041 13.3 0.7 1.3 1 0 0 1 1 1 0 CSL zinc finger A2L_zn_ribbon PF08792.5 EPA05053.1 - 0.039 13.4 3.6 0.38 10.2 2.5 2.0 1 1 0 1 1 1 0 A2L zinc ribbon domain OrfB_Zn_ribbon PF07282.6 EPA05053.1 - 0.05 13.2 0.5 0.073 12.7 0.3 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain TerY-C PF15616.1 EPA05053.1 - 0.052 13.4 0.4 0.075 12.9 0.3 1.5 1 1 0 1 1 1 0 TerY-C metal binding domain zf-C2H2_6 PF13912.1 EPA05053.1 - 0.053 13.4 0.9 0.61 10.0 0.0 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger BssC_TutF PF08201.6 EPA05053.1 - 0.054 12.9 0.6 0.82 9.2 0.5 1.9 1 1 1 2 2 2 0 BssC/TutF protein CpXC PF14353.1 EPA05053.1 - 0.095 12.6 1.7 1.1 9.2 0.1 2.0 1 1 1 2 2 2 0 CpXC protein DUF164 PF02591.10 EPA05053.1 - 0.11 12.3 3.1 0.65 9.8 2.2 2.0 1 1 0 1 1 1 0 Putative zinc ribbon domain RNA_POL_M_15KD PF02150.11 EPA05053.1 - 0.12 12.0 1.8 0.99 9.1 1.2 2.0 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit IBR PF01485.16 EPA05053.1 - 0.14 12.0 1.1 0.23 11.3 0.7 1.3 1 1 0 1 1 1 0 IBR domain COX5B PF01215.14 EPA05053.1 - 0.15 11.7 0.1 0.17 11.5 0.1 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Vb zf-IS66 PF13005.2 EPA05053.1 - 0.15 12.0 0.8 2.1 8.4 0.1 2.3 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 XPA_N PF01286.13 EPA05053.1 - 0.2 11.3 1.7 9.6 5.9 0.4 2.1 2 0 0 2 2 2 0 XPA protein N-terminal RRN7 PF11781.3 EPA05053.1 - 0.23 10.9 1.8 0.32 10.5 0.1 1.9 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-H2C2_2 PF13465.1 EPA05053.1 - 0.24 11.7 1.5 1.2 9.5 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger double domain Ogr_Delta PF04606.7 EPA05053.1 - 0.33 10.6 1.7 3.1 7.5 0.1 2.1 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Lar_restr_allev PF14354.1 EPA05053.1 - 0.39 11.0 2.3 1.9 8.8 1.6 1.9 1 1 0 1 1 1 0 Restriction alleviation protein Lar DUF1272 PF06906.6 EPA05053.1 - 1.8 8.5 4.8 35 4.3 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1272) zf-dskA_traR PF01258.12 EPA05053.1 - 8.3 6.2 8.2 18 5.1 1.5 2.1 1 1 1 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger HTH_5 PF01022.15 EPA05054.1 - 7.7e-11 41.4 0.4 1.3e-10 40.7 0.3 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.2 EPA05054.1 - 0.00026 20.7 0.2 0.00038 20.1 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_34 PF13601.1 EPA05054.1 - 0.0032 17.4 0.6 0.039 13.9 0.3 2.1 2 0 0 2 2 2 1 Winged helix DNA-binding domain TrmB PF01978.14 EPA05054.1 - 0.0067 16.1 0.1 0.011 15.4 0.1 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 EPA05054.1 - 0.0068 15.7 0.2 0.015 14.6 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.7 EPA05054.1 - 0.017 14.7 0.2 0.035 13.7 0.2 1.5 1 0 0 1 1 1 0 HTH domain B-block_TFIIIC PF04182.7 EPA05054.1 - 0.064 13.1 0.1 0.15 11.9 0.0 1.7 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC HTH_23 PF13384.1 EPA05054.1 - 0.08 12.6 0.1 0.56 9.9 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain BPD_transp_1 PF00528.17 EPA05055.1 - 1.4e-21 76.8 17.0 1.4e-21 76.8 11.8 1.5 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component B12-binding PF02310.14 EPA05056.1 - 6.6e-19 67.9 0.0 1e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 B12 binding domain B12-binding_2 PF02607.12 EPA05056.1 - 3.6e-15 55.7 0.0 6.2e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 B12 binding domain HTH_AsnC-type PF13404.1 EPA05057.1 - 1.4e-13 50.1 0.0 2.6e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.1 EPA05057.1 - 4.4e-13 48.3 0.3 8e-13 47.5 0.2 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.16 EPA05057.1 - 4.7e-12 45.4 0.3 7.2e-12 44.8 0.2 1.3 1 0 0 1 1 1 1 AsnC family HTH_11 PF08279.7 EPA05057.1 - 0.00039 20.0 0.4 0.001 18.6 0.1 1.9 2 0 0 2 2 2 1 HTH domain HTH_27 PF13463.1 EPA05057.1 - 0.00063 20.0 0.1 0.013 15.7 0.0 2.3 1 1 0 2 2 2 1 Winged helix DNA-binding domain ACT_4 PF13291.1 EPA05057.1 - 0.002 18.4 1.2 1.3 9.3 0.2 2.4 2 0 0 2 2 2 2 ACT domain TrmB PF01978.14 EPA05057.1 - 0.0047 16.6 1.4 0.075 12.7 0.1 2.2 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB DDRGK PF09756.4 EPA05057.1 - 0.0058 16.0 2.7 0.012 15.0 0.2 2.1 2 0 0 2 2 2 1 DDRGK domain MarR_2 PF12802.2 EPA05057.1 - 0.0058 16.2 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 MarR family DUF2774 PF11242.3 EPA05057.1 - 0.0076 16.2 0.3 0.14 12.1 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2774) HTH_5 PF01022.15 EPA05057.1 - 0.0079 15.8 0.0 0.029 14.0 0.0 1.9 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_Tnp_ISL3 PF13542.1 EPA05057.1 - 0.0083 15.2 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 MarR PF01047.17 EPA05057.1 - 0.009 15.7 0.3 0.023 14.4 0.1 1.8 2 0 0 2 2 1 1 MarR family Sigma70_r4 PF04545.11 EPA05057.1 - 0.012 14.9 0.0 0.033 13.5 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 Mga PF05043.8 EPA05057.1 - 0.018 15.2 0.1 0.033 14.4 0.0 1.5 1 0 0 1 1 1 0 Mga helix-turn-helix domain NapD PF03927.8 EPA05057.1 - 0.021 14.6 1.4 0.049 13.4 0.8 1.7 1 1 0 1 1 1 0 NapD protein FeoC PF09012.5 EPA05057.1 - 0.022 14.4 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 FeoC like transcriptional regulator HTH_IclR PF09339.5 EPA05057.1 - 0.03 13.9 0.0 0.051 13.1 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF977 PF06163.6 EPA05057.1 - 0.033 13.9 0.2 0.092 12.4 0.0 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF977) HTH_Mga PF08280.6 EPA05057.1 - 0.035 13.8 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_34 PF13601.1 EPA05057.1 - 0.039 13.9 0.2 0.14 12.2 0.0 1.9 1 1 0 1 1 1 0 Winged helix DNA-binding domain HTH_DeoR PF08220.7 EPA05057.1 - 0.04 13.4 0.4 0.16 11.5 0.0 2.0 2 1 1 3 3 3 0 DeoR-like helix-turn-helix domain HTH_9 PF08221.6 EPA05057.1 - 0.058 13.2 0.1 0.25 11.2 0.0 1.9 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Stk19 PF10494.4 EPA05057.1 - 0.089 12.1 0.3 0.096 12.0 0.2 1.3 1 0 0 1 1 1 0 Serine-threonine protein kinase 19 ELFV_dehydrog PF00208.16 EPA05058.1 - 3.2e-67 226.6 1.9 4.3e-67 226.2 1.3 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 EPA05058.1 - 1.5e-46 157.1 0.0 2.6e-46 156.4 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Proteasome PF00227.21 EPA05059.1 - 3.5e-48 163.4 1.6 4.4e-48 163.1 1.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EPA05059.1 - 5.2e-13 48.0 1.5 3.1e-11 42.3 0.1 2.7 2 0 0 2 2 2 2 Proteasome subunit A N-terminal signature CTP-dep_RFKase PF01982.11 EPA05060.1 - 4.2e-43 145.8 0.1 6.3e-43 145.2 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF120 HicB PF05534.7 EPA05060.1 - 0.048 13.2 0.1 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 HicB family Aminotran_3 PF00202.16 EPA05061.1 - 2.6e-105 352.0 0.0 3.2e-105 351.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 EPA05061.1 - 0.00091 18.2 0.0 0.0019 17.1 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II DUF2931 PF11153.3 EPA05061.1 - 0.035 13.4 0.0 0.052 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2931) GATase PF00117.23 EPA05062.1 - 1.8e-25 89.5 0.0 2.5e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I HTS PF04204.11 EPA05062.1 - 1.9e-06 26.8 0.0 3.6e-06 25.9 0.0 1.4 2 0 0 2 2 2 1 Homoserine O-succinyltransferase Peptidase_C26 PF07722.8 EPA05062.1 - 2.6e-06 27.0 0.1 1.2e-05 24.8 0.0 2.0 2 1 0 2 2 2 1 Peptidase C26 DJ-1_PfpI PF01965.19 EPA05062.1 - 0.086 12.3 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 DJ-1/PfpI family Pterin_bind PF00809.17 EPA05063.1 - 6.4e-23 81.2 0.0 7.6e-23 80.9 0.0 1.1 1 0 0 1 1 1 1 Pterin binding enzyme CdhD PF03599.11 EPA05063.1 - 2.5e-05 22.9 0.0 3e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit N6_N4_Mtase PF01555.13 EPA05064.1 - 3.8e-36 124.7 4.9 4.6e-36 124.4 3.4 1.1 1 0 0 1 1 1 1 DNA methylase Methyltransf_26 PF13659.1 EPA05064.1 - 5e-09 36.2 0.0 0.00093 19.2 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain UPF0020 PF01170.13 EPA05064.1 - 3.9e-06 26.5 0.0 0.035 13.6 0.0 2.3 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 Ubie_methyltran PF01209.13 EPA05065.1 - 1.7e-17 63.3 0.0 2.1e-17 63.0 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 EPA05065.1 - 1.1e-12 48.2 0.0 1.6e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA05065.1 - 6.8e-09 35.6 0.0 9.7e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA05065.1 - 5e-08 32.6 0.0 7.2e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA05065.1 - 1.7e-07 31.7 0.0 2.6e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EPA05065.1 - 2.5e-06 27.7 0.0 3.7e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA05065.1 - 6e-06 26.6 0.0 1e-05 25.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EPA05065.1 - 0.056 12.8 0.0 0.12 11.7 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_8 PF05148.10 EPA05065.1 - 0.067 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_26 PF13659.1 EPA05065.1 - 0.082 12.9 0.0 0.39 10.7 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain P-II PF00543.17 EPA05066.1 - 1.6e-19 70.2 0.7 3.2e-19 69.2 0.5 1.4 1 1 0 1 1 1 1 Nitrogen regulatory protein P-II DUF2179 PF10035.4 EPA05066.1 - 0.11 12.1 0.0 0.53 9.9 0.0 2.1 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2179) CaM-KIIN PF15170.1 EPA05066.1 - 0.13 12.2 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Calcium/calmodulin-dependent protein kinase II inhibitor Fe-S_biosyn PF01521.15 EPA05067.1 - 2.4e-21 75.7 0.0 2.7e-21 75.6 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis RimK PF08443.6 EPA05068.1 - 1e-45 155.5 0.0 1.3e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.11 EPA05068.1 - 1.3e-09 37.4 0.0 1.7e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_4 PF13535.1 EPA05068.1 - 1.5e-08 34.5 0.0 2.3e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 EPA05068.1 - 1.9e-07 31.1 0.0 3.1e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EPA05068.1 - 0.00011 21.0 0.0 0.00069 18.4 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon CPSase_L_D2 PF02786.12 EPA05068.1 - 0.0056 15.9 0.0 0.0088 15.3 0.0 1.5 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_5 PF13549.1 EPA05068.1 - 0.031 13.4 0.0 0.054 12.6 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp PF02222.17 EPA05068.1 - 0.05 12.9 0.0 0.079 12.3 0.0 1.5 1 1 0 1 1 1 0 ATP-grasp domain MFS_1 PF07690.11 EPA05069.1 - 7.9e-26 90.5 38.1 6.2e-23 81.0 15.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4094 PF13334.1 EPA05069.1 - 0.02 15.2 0.0 0.051 13.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) MFS_1 PF07690.11 EPA05071.1 - 4.9e-43 147.2 69.6 5.3e-32 110.9 24.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.8 EPA05071.1 - 0.0011 17.1 12.0 0.0036 15.4 8.3 1.7 1 1 0 1 1 1 1 Transmembrane secretion effector PUCC PF03209.10 EPA05071.1 - 0.0018 17.0 7.4 0.0018 17.0 5.2 2.2 2 0 0 2 2 2 2 PUCC protein DUF1228 PF06779.9 EPA05071.1 - 0.046 13.7 7.5 0.052 13.5 0.5 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1228) MttA_Hcf106 PF02416.11 EPA05072.1 - 3.2e-07 29.3 0.0 3.4e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 mttA/Hcf106 family Phage_Mu_Gam PF07352.7 EPA05072.1 - 0.00035 20.1 0.1 0.00041 19.8 0.1 1.1 1 0 0 1 1 1 1 Bacteriophage Mu Gam like protein DUF520 PF04461.8 EPA05072.1 - 0.02 14.7 0.2 0.024 14.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF520) COG2 PF06148.6 EPA05072.1 - 0.041 13.7 0.1 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Lip_A_acyltrans PF03279.8 EPA05072.1 - 0.1 11.4 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Bacterial lipid A biosynthesis acyltransferase Peptidase_M20 PF01546.23 EPA05073.1 - 1.9e-30 105.8 0.1 2.4e-30 105.4 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EPA05073.1 - 1.7e-11 43.8 0.0 3.7e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M42 PF05343.9 EPA05073.1 - 3.7e-05 22.6 1.1 0.07 11.8 0.1 2.7 2 1 1 3 3 3 2 M42 glutamyl aminopeptidase Toprim PF01751.17 EPA05074.1 - 2.2e-06 27.5 0.2 1.1e-05 25.3 0.1 2.2 1 1 0 1 1 1 1 Toprim domain Toprim_4 PF13662.1 EPA05074.1 - 5.6e-05 23.0 0.0 0.00012 22.0 0.0 1.5 1 1 0 1 1 1 1 Toprim domain Toprim_3 PF13362.1 EPA05074.1 - 0.0027 17.8 0.0 0.0035 17.5 0.0 1.1 1 0 0 1 1 1 1 Toprim domain Toprim_2 PF13155.1 EPA05074.1 - 0.02 15.1 0.0 0.026 14.8 0.0 1.4 1 1 0 1 1 1 0 Toprim-like Semialdhyde_dh PF01118.19 EPA05075.1 - 2.2e-35 121.5 0.0 3.7e-35 120.8 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.13 EPA05075.1 - 3.9e-19 69.2 0.0 6.6e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain GFO_IDH_MocA PF01408.17 EPA05075.1 - 0.00012 22.5 0.0 0.00026 21.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DapB_N PF01113.15 EPA05075.1 - 0.00018 21.4 0.0 0.00036 20.4 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Saccharop_dh PF03435.13 EPA05075.1 - 0.00053 19.0 0.0 0.00061 18.8 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NAD_binding_10 PF13460.1 EPA05075.1 - 0.064 13.2 0.0 0.16 11.9 0.0 1.7 1 1 0 1 1 1 0 NADH(P)-binding F420_oxidored PF03807.12 EPA05075.1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ATP-grasp_5 PF13549.1 EPA05076.1 - 6.6e-68 228.2 0.6 9.9e-68 227.6 0.4 1.3 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.1 EPA05076.1 - 5.5e-48 162.0 0.2 1.2e-47 160.9 0.1 1.7 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 EPA05076.1 - 6.7e-25 87.5 0.0 3e-24 85.3 0.0 2.2 2 0 0 2 2 2 1 CoA binding domain CoA_binding PF02629.14 EPA05076.1 - 1.4e-09 38.2 1.6 5.1e-09 36.5 0.1 2.8 3 0 0 3 3 3 1 CoA binding domain ATP-grasp_2 PF08442.5 EPA05076.1 - 7.8e-08 31.9 0.8 1.6e-07 30.9 0.6 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.1 EPA05076.1 - 0.00016 21.4 0.0 0.00054 19.7 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp PF02222.17 EPA05076.1 - 0.017 14.4 0.0 0.043 13.1 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain RimK PF08443.6 EPA05076.1 - 0.043 13.2 0.2 0.13 11.7 0.1 1.7 1 0 0 1 1 1 0 RimK-like ATP-grasp domain AA_kinase PF00696.23 EPA05077.1 - 2.3e-34 119.0 3.5 2.6e-34 118.8 2.4 1.0 1 0 0 1 1 1 1 Amino acid kinase family zinc_ribbon_5 PF13719.1 EPA05078.1 - 8.7e-05 22.0 1.2 0.09 12.3 0.1 2.1 2 0 0 2 2 2 2 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA05078.1 - 0.00018 21.1 1.1 0.18 11.5 0.1 2.1 2 0 0 2 2 2 2 zinc-ribbon domain DNA_RNApol_7kD PF03604.8 EPA05078.1 - 0.002 17.5 2.6 0.15 11.5 1.9 2.5 1 1 2 3 3 3 2 DNA directed RNA polymerase, 7 kDa subunit TF_Zn_Ribbon PF08271.7 EPA05078.1 - 0.0029 16.8 0.8 0.0049 16.1 0.6 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding RNA_POL_M_15KD PF02150.11 EPA05078.1 - 0.0029 17.2 0.3 0.0046 16.6 0.2 1.3 1 0 0 1 1 1 1 RNA polymerases M/15 Kd subunit zf-HYPF PF07503.7 EPA05078.1 - 0.018 14.4 1.9 0.18 11.2 1.3 2.0 1 1 0 1 1 1 0 HypF finger A2L_zn_ribbon PF08792.5 EPA05078.1 - 0.047 13.1 1.7 1 8.8 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-ribbon_3 PF13248.1 EPA05078.1 - 0.049 12.8 0.2 7 6.0 0.0 2.1 2 0 0 2 2 2 0 zinc-ribbon domain DUF2387 PF09526.5 EPA05078.1 - 0.06 13.2 0.6 0.075 12.9 0.4 1.1 1 0 0 1 1 1 0 Probable metal-binding protein (DUF2387) DZR PF12773.2 EPA05078.1 - 0.065 13.0 0.7 0.11 12.3 0.5 1.4 1 1 0 1 1 1 0 Double zinc ribbon HypA PF01155.14 EPA05078.1 - 0.074 12.7 0.5 0.093 12.4 0.4 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Ribosomal_S27e PF01667.12 EPA05078.1 - 0.11 12.0 0.3 0.14 11.7 0.2 1.3 1 0 0 1 1 1 0 Ribosomal protein S27 Prok-RING_1 PF14446.1 EPA05078.1 - 0.12 12.1 4.1 0.29 10.8 2.9 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING_3 PF14369.1 EPA05078.1 - 0.12 12.4 1.3 0.19 11.7 0.9 1.3 1 0 0 1 1 1 0 zinc-finger Lar_restr_allev PF14354.1 EPA05078.1 - 0.13 12.5 2.6 0.72 10.1 1.8 1.9 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-trcl PF13451.1 EPA05078.1 - 0.24 11.0 2.8 0.57 9.8 0.1 2.1 2 0 0 2 2 2 0 Probable zinc-binding domain Zn-ribbon_8 PF09723.5 EPA05078.1 - 0.27 11.2 3.0 1.4 8.9 0.1 1.9 1 1 1 2 2 2 0 Zinc ribbon domain DUF4182 PF13790.1 EPA05078.1 - 0.37 10.6 2.6 2.9 7.7 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4182) ABC_tran PF00005.22 EPA05079.1 - 2.6e-31 108.7 0.0 4.3e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EPA05079.1 - 1.6e-11 44.7 0.0 2.6e-05 24.3 0.0 2.2 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.1 EPA05079.1 - 0.00048 20.1 0.1 0.0011 18.9 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain DUF258 PF03193.11 EPA05079.1 - 0.00082 18.5 0.0 0.0011 18.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA PF00004.24 EPA05079.1 - 0.0013 18.8 0.3 0.015 15.4 0.2 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EPA05079.1 - 0.0033 18.2 0.1 0.0061 17.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EPA05079.1 - 0.0041 16.6 0.0 0.0082 15.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 EPA05079.1 - 0.0043 16.1 0.0 0.21 10.6 0.0 2.1 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EPA05079.1 - 0.0075 16.4 0.1 0.022 14.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.14 EPA05079.1 - 0.011 15.0 0.2 1.8 7.7 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 EPA05079.1 - 0.011 15.1 0.0 0.022 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EPA05079.1 - 0.013 15.4 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.10 EPA05079.1 - 0.018 13.7 0.0 0.027 13.1 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_5 PF07728.9 EPA05079.1 - 0.021 14.5 0.0 0.053 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Arch_ATPase PF01637.13 EPA05079.1 - 0.022 14.4 0.0 0.045 13.4 0.0 1.4 1 1 0 1 1 1 0 Archaeal ATPase Miro PF08477.8 EPA05079.1 - 0.025 15.0 0.0 0.08 13.4 0.0 1.9 2 1 0 2 2 2 0 Miro-like protein NACHT PF05729.7 EPA05079.1 - 0.033 13.8 0.0 0.062 12.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_23 PF13476.1 EPA05079.1 - 0.037 14.3 0.0 0.071 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 EPA05079.1 - 0.041 13.2 0.2 0.21 11.0 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein RNA_helicase PF00910.17 EPA05079.1 - 0.041 14.0 0.0 0.16 12.1 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.1 EPA05079.1 - 0.084 13.1 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_ATPase PF09818.4 EPA05079.1 - 0.097 11.2 0.3 0.24 9.9 0.1 1.7 2 0 0 2 2 2 0 Predicted ATPase of the ABC class DUF2387 PF09526.5 EPA05080.1 - 0.0013 18.6 0.5 0.0015 18.4 0.4 1.1 1 0 0 1 1 1 1 Probable metal-binding protein (DUF2387) Fe_dep_repr_C PF02742.10 EPA05081.1 - 1.2e-20 72.9 0.1 1.4e-20 72.6 0.1 1.1 1 0 0 1 1 1 1 Iron dependent repressor, metal binding and dimerisation domain UPF0047 PF01894.12 EPA05082.1 - 3.5e-08 33.2 0.0 3.6e-08 33.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 Radical_SAM PF04055.16 EPA05083.1 - 8.8e-14 52.0 0.0 1.2e-13 51.5 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily UbiD PF01977.11 EPA05086.1 - 9e-154 511.8 0.1 1e-153 511.6 0.0 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Aminotran_3 PF00202.16 EPA05087.1 - 1.9e-54 184.7 0.0 2.3e-54 184.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III VIT1 PF01988.14 EPA05089.1 - 9.3e-26 90.6 0.1 1.1e-25 90.4 0.1 1.0 1 0 0 1 1 1 1 VIT family Carbpep_Y_N PF05388.6 EPA05089.1 - 0.049 13.7 0.0 0.067 13.3 0.0 1.3 1 0 0 1 1 1 0 Carboxypeptidase Y pro-peptide A2M_N PF01835.14 EPA05090.1 - 2.9e-05 24.2 0.2 0.067 13.4 0.0 2.2 2 0 0 2 2 2 2 MG2 domain FlgD_ig PF13860.1 EPA05090.1 - 4.2e-05 23.1 1.4 0.018 14.8 0.1 2.6 2 1 0 2 2 2 2 FlgD Ig-like domain PsbH PF00737.15 EPA05090.1 - 0.0015 18.0 0.3 0.0039 16.7 0.2 1.6 1 0 0 1 1 1 1 Photosystem II 10 kDa phosphoprotein TrmB PF01978.14 EPA05091.1 - 3.6e-15 55.4 0.0 2.1e-14 52.9 0.0 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.2 EPA05091.1 - 5.1e-05 22.8 0.0 9e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR PF01047.17 EPA05091.1 - 0.00031 20.3 0.0 0.0012 18.4 0.0 1.9 2 0 0 2 2 2 1 MarR family HTH_11 PF08279.7 EPA05091.1 - 0.00098 18.7 0.0 0.0029 17.2 0.0 1.8 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.1 EPA05091.1 - 0.001 18.3 0.0 0.0021 17.4 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Fe_dep_repress PF01325.14 EPA05091.1 - 0.0025 17.7 0.0 0.01 15.7 0.0 2.1 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain Regulator_TrmB PF11495.3 EPA05091.1 - 0.0084 15.1 0.1 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB Ftsk_gamma PF09397.5 EPA05091.1 - 0.02 14.5 0.0 0.042 13.5 0.0 1.5 1 0 0 1 1 1 0 Ftsk gamma domain HTH_IclR PF09339.5 EPA05091.1 - 0.039 13.5 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain Pedibin PF08182.6 EPA05091.1 - 0.085 12.3 1.5 0.16 11.4 1.1 1.4 1 0 0 1 1 1 0 Pedibin/Hym-346 family HTH_20 PF12840.2 EPA05091.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain RimK PF08443.6 EPA05092.1 - 0.013 14.9 0.2 0.014 14.8 0.1 1.1 1 0 0 1 1 1 0 RimK-like ATP-grasp domain VIT1 PF01988.14 EPA05093.1 - 5.9e-06 25.9 3.9 7e-06 25.6 2.7 1.0 1 0 0 1 1 1 1 VIT family DUF204 PF02659.10 EPA05093.1 - 1 9.5 5.8 2.9 8.0 4.1 1.9 1 1 0 1 1 1 0 Domain of unknown function DUF MFS_1 PF07690.11 EPA05094.1 - 1.3e-26 93.1 69.0 1.5e-20 73.1 24.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.8 EPA05094.1 - 0.22 9.5 6.3 0.88 7.6 0.2 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector TM_helix PF05552.7 EPA05095.1 - 2.3e-11 43.1 4.9 3.5e-05 23.3 0.2 2.9 2 0 0 2 2 2 2 Conserved TM helix MS_channel PF00924.13 EPA05095.1 - 4.8e-07 29.3 8.1 4.8e-07 29.3 5.6 3.2 3 1 0 3 3 3 1 Mechanosensitive ion channel DUF502 PF04367.8 EPA05095.1 - 0.14 11.9 3.7 8.6 6.1 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF502) DUF1043 PF06295.7 EPA05095.1 - 0.33 10.6 2.7 2.7 7.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) NPCC PF08058.6 EPA05095.1 - 0.57 10.0 10.8 1.9 8.3 1.0 2.5 2 1 0 2 2 2 0 Nuclear pore complex component FA_desaturase PF00487.19 EPA05095.1 - 3.9 6.8 8.0 3 7.2 4.1 1.9 1 1 0 1 1 1 0 Fatty acid desaturase Zn_Tnp_IS1595 PF12760.2 EPA05096.1 - 0.049 13.4 1.4 0.08 12.7 1.0 1.4 1 1 0 1 1 1 0 Transposase zinc-ribbon domain DUF4428 PF14471.1 EPA05096.1 - 0.062 13.0 2.9 0.22 11.2 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4428) DUF4379 PF14311.1 EPA05096.1 - 0.077 12.8 0.4 0.11 12.2 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4379) Gemini_V1 PF01524.12 EPA05096.1 - 0.12 12.4 0.0 0.13 12.2 0.0 1.1 1 0 0 1 1 1 0 Geminivirus V1 protein C1_4 PF07975.7 EPA05096.1 - 0.32 11.0 1.9 0.41 10.6 1.3 1.1 1 0 0 1 1 1 0 TFIIH C1-like domain Phos_pyr_kin PF08543.7 EPA05097.1 - 2.2e-74 249.7 1.2 2.2e-74 249.7 0.8 1.4 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase Aldolase_2 PF10120.4 EPA05097.1 - 4.4e-28 97.7 0.1 8.3e-28 96.8 0.0 1.5 1 0 0 1 1 1 1 Putative aldolase PfkB PF00294.19 EPA05097.1 - 3.5e-12 46.0 0.0 4.9e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Carb_kinase PF01256.12 EPA05097.1 - 0.00095 18.5 0.4 0.0023 17.2 0.3 1.5 1 1 0 1 1 1 1 Carbohydrate kinase HK PF02110.10 EPA05097.1 - 0.043 12.9 0.3 0.17 11.0 0.2 1.9 1 1 0 1 1 1 0 Hydroxyethylthiazole kinase family KH_5 PF13184.1 EPA05097.1 - 0.088 12.6 1.7 0.2 11.4 0.2 2.3 2 0 0 2 2 2 0 NusA-like KH domain Baculo_PEP_C PF04513.7 EPA05098.1 - 0.0036 17.1 3.7 0.0082 15.9 2.6 1.6 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.7 EPA05098.1 - 0.005 16.0 3.6 0.0077 15.4 2.5 1.3 1 0 0 1 1 1 1 Reovirus sigma C capsid protein Y_Y_Y PF07495.8 EPA05098.1 - 0.012 15.3 0.3 6.4 6.6 0.0 2.5 2 0 0 2 2 2 0 Y_Y_Y domain Filamin PF00630.14 EPA05098.1 - 0.052 14.1 0.0 0.13 12.8 0.0 1.9 1 1 0 1 1 1 0 Filamin/ABP280 repeat Ran-binding PF05508.6 EPA05098.1 - 0.066 12.0 0.9 0.11 11.3 0.6 1.3 1 0 0 1 1 1 0 RanGTP-binding protein Atg14 PF10186.4 EPA05098.1 - 0.13 11.1 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4480 PF13715.1 EPA05099.1 - 7.8e-07 29.0 0.4 1.7e-06 28.0 0.1 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4480) CarboxypepD_reg PF13620.1 EPA05099.1 - 4.1e-06 26.7 0.1 8.1e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DegS PF05384.6 EPA05099.1 - 0.14 11.4 3.3 0.28 10.3 0.3 2.1 2 0 0 2 2 2 0 Sensor protein DegS GSDH PF07995.6 EPA05100.1 - 1.2e-35 123.1 0.0 2.3e-35 122.2 0.0 1.4 1 1 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Shugoshin_N PF07558.6 EPA05102.1 - 0.00093 18.8 1.4 0.0012 18.5 1.0 1.2 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region HALZ PF02183.13 EPA05102.1 - 0.0098 15.5 3.8 0.017 14.8 2.6 1.4 1 0 0 1 1 1 1 Homeobox associated leucine zipper TMF_TATA_bd PF12325.3 EPA05102.1 - 0.013 15.1 1.6 0.014 15.1 1.1 1.2 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Herpes_BLRF2 PF05812.7 EPA05102.1 - 0.021 14.6 3.5 0.028 14.2 2.4 1.2 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Nnf1 PF03980.9 EPA05102.1 - 0.041 13.8 1.1 0.047 13.6 0.8 1.3 1 0 0 1 1 1 0 Nnf1 Mto2_bdg PF12808.2 EPA05102.1 - 0.044 13.8 3.1 0.07 13.2 2.1 1.3 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DivIC PF04977.10 EPA05102.1 - 0.057 12.9 2.2 0.059 12.8 1.3 1.3 1 1 0 1 1 1 0 Septum formation initiator DUF1875 PF08961.5 EPA05102.1 - 0.086 12.1 2.8 0.098 11.9 1.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1875) bZIP_1 PF00170.16 EPA05102.1 - 0.1 12.5 5.1 0.089 12.7 3.0 1.3 1 1 0 1 1 1 0 bZIP transcription factor CCDC144C PF14915.1 EPA05102.1 - 0.16 10.8 6.4 0.16 10.8 4.4 1.0 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region DUF972 PF06156.8 EPA05102.1 - 0.38 11.1 3.4 0.38 11.1 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF641 PF04859.7 EPA05102.1 - 0.46 10.2 2.6 0.49 10.1 1.8 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) ATG16 PF08614.6 EPA05102.1 - 0.63 9.8 5.6 0.65 9.7 3.9 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Rootletin PF15035.1 EPA05102.1 - 0.93 9.4 5.0 0.91 9.4 3.5 1.0 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion fn3 PF00041.16 EPA05103.1 - 5e-34 116.2 21.3 1e-13 51.1 2.8 3.2 3 0 0 3 3 3 3 Fibronectin type III domain SusE PF14292.1 EPA05103.1 - 7.3e-06 25.8 11.4 0.0074 16.1 0.8 3.3 2 1 1 3 3 3 3 SusE outer membrane protein Atu4866 PF11512.3 EPA05103.1 - 0.23 11.2 4.2 11 5.8 0.0 3.1 3 0 0 3 3 3 0 Agrobacterium tumefaciens protein Atu4866 A2M_N PF01835.14 EPA05104.1 - 0.00028 21.0 0.0 0.00036 20.7 0.0 1.2 1 0 0 1 1 1 1 MG2 domain A2M_N PF01835.14 EPA05105.1 - 4.9e-13 49.1 1.4 5.9e-05 23.2 0.0 4.3 3 2 0 3 3 3 2 MG2 domain A2M_N_2 PF07703.9 EPA05105.1 - 0.0037 17.0 0.2 0.034 13.9 0.0 2.3 2 0 0 2 2 2 1 Alpha-2-macroglobulin family N-terminal region Arrestin_C PF02752.17 EPA05105.1 - 0.11 12.5 1.5 0.85 9.7 0.1 3.0 3 1 0 3 3 3 0 Arrestin (or S-antigen), C-terminal domain He_PIG PF05345.7 EPA05105.1 - 1.2 9.2 5.0 12 6.0 0.2 3.3 3 0 0 3 3 3 0 Putative Ig domain UPF0047 PF01894.12 EPA05107.1 - 2.3e-22 79.0 0.1 2.9e-22 78.6 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 eRF1_1 PF03463.10 EPA05108.1 - 2.9e-20 72.2 0.4 3.4e-20 71.9 0.3 1.1 1 0 0 1 1 1 1 eRF1 domain 1 TruB_N PF01509.13 EPA05110.1 - 2.6e-25 89.3 0.2 4.7e-15 56.0 0.0 3.3 1 1 1 2 2 2 2 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 EPA05110.1 - 9.5e-20 70.1 0.2 1.6e-19 69.3 0.1 1.4 1 0 0 1 1 1 1 PUA domain DKCLD PF08068.7 EPA05110.1 - 1.7e-12 47.0 0.0 3.3e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 DKCLD (NUC011) domain NDUF_B6 PF09782.4 EPA05111.1 - 0.015 15.1 2.0 0.023 14.5 1.4 1.2 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit DUF684 PF05075.9 EPA05111.1 - 0.045 12.3 0.2 0.063 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF684) DUF473 PF04322.7 EPA05111.1 - 0.047 13.3 0.2 0.073 12.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF473) Ribosomal_S5 PF00333.15 EPA05112.1 - 2e-19 69.1 0.4 3.2e-19 68.4 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 EPA05112.1 - 4.3e-15 54.7 0.1 9.4e-15 53.6 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain DUF3628 PF12300.3 EPA05112.1 - 1.2 9.2 9.9 1.9 8.4 6.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3628) DAO PF01266.19 EPA05113.1 - 2.5e-40 138.4 0.0 3.2e-40 138.1 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Mqo PF06039.10 EPA05113.1 - 2.9e-13 48.8 0.0 3.8e-07 28.6 0.0 2.1 2 0 0 2 2 2 2 Malate:quinone oxidoreductase (Mqo) Pyr_redox_3 PF13738.1 EPA05113.1 - 8.7e-05 22.6 0.0 0.28 11.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EPA05113.1 - 0.00025 20.9 0.2 0.0026 17.6 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 EPA05113.1 - 0.00091 18.2 0.0 0.69 8.7 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein NAD_binding_8 PF13450.1 EPA05113.1 - 0.0036 17.2 0.0 0.0094 15.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EPA05113.1 - 0.0099 16.2 3.8 2.5 8.5 0.0 3.5 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Ribosomal_L30 PF00327.15 EPA05115.1 - 1.3e-14 53.4 0.1 2.4e-14 52.6 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Apc9 PF12856.2 EPA05116.1 - 0.083 12.9 0.0 0.089 12.8 0.0 1.1 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 9 SHOCT PF09851.4 EPA05117.1 - 2e-08 33.4 5.6 3.6e-08 32.6 3.9 1.4 1 0 0 1 1 1 1 Short C-terminal domain GvpG PF05120.7 EPA05117.1 - 0.053 13.3 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 Gas vesicle protein G RNA_pol_A_CTD PF03118.10 EPA05117.1 - 1.9 7.9 6.7 0.38 10.2 1.3 2.3 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain FlgD_ig PF13860.1 EPA05118.1 - 0.043 13.5 0.1 0.17 11.6 0.0 2.0 1 1 1 2 2 2 0 FlgD Ig-like domain zf-ribbon_3 PF13248.1 EPA05119.1 - 0.0022 17.1 1.6 0.33 10.2 0.2 2.4 2 0 0 2 2 2 2 zinc-ribbon domain zinc_ribbon_2 PF13240.1 EPA05119.1 - 0.15 11.5 10.6 0.39 10.2 7.3 1.8 1 1 0 1 1 1 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.7 EPA05119.1 - 0.24 10.7 12.5 1.1 8.6 1.4 2.3 2 1 0 2 2 2 0 TFIIB zinc-binding DUF2387 PF09526.5 EPA05119.1 - 1.8 8.5 9.6 6.4 6.7 0.5 2.1 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) AAA_18 PF13238.1 EPA05120.1 - 1.7e-12 47.7 0.0 3e-12 46.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EPA05120.1 - 1.8e-06 28.7 0.0 3e-06 28.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 EPA05120.1 - 4.5e-05 23.2 0.4 5.9e-05 22.8 0.3 1.5 1 1 0 1 1 1 1 Archaeal ATPase MobB PF03205.9 EPA05120.1 - 4.9e-05 23.0 0.3 0.00011 21.8 0.2 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B KTI12 PF08433.5 EPA05120.1 - 5.3e-05 22.5 0.1 7e-05 22.1 0.1 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_28 PF13521.1 EPA05120.1 - 0.0001 22.2 0.0 0.00016 21.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.17 EPA05120.1 - 0.00015 21.3 0.2 0.00032 20.1 0.2 1.4 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.1 EPA05120.1 - 0.00019 21.5 0.1 0.0003 20.8 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain Miro PF08477.8 EPA05120.1 - 0.00022 21.7 0.4 0.00037 20.9 0.1 1.6 2 0 0 2 2 1 1 Miro-like protein NACHT PF05729.7 EPA05120.1 - 0.0003 20.4 0.0 0.00042 20.0 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 EPA05120.1 - 0.00031 20.8 0.1 0.00069 19.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 EPA05120.1 - 0.00032 20.3 0.0 0.00052 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EPA05120.1 - 0.00034 20.8 0.1 0.00067 19.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EPA05120.1 - 0.00042 20.2 0.0 0.00066 19.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.22 EPA05120.1 - 0.00049 20.4 1.2 0.00059 20.1 0.8 1.5 1 1 0 1 1 1 1 ABC transporter NTPase_1 PF03266.10 EPA05120.1 - 0.00055 19.6 2.6 0.0024 17.6 0.2 2.2 1 1 0 2 2 2 1 NTPase cobW PF02492.14 EPA05120.1 - 0.00083 18.8 0.1 0.0016 17.9 0.1 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.18 EPA05120.1 - 0.0009 19.1 0.8 0.0012 18.8 0.6 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_19 PF13245.1 EPA05120.1 - 0.0027 17.4 0.0 0.0056 16.4 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain ATP_bind_1 PF03029.12 EPA05120.1 - 0.0036 16.8 0.4 0.0085 15.6 0.0 1.7 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein DUF258 PF03193.11 EPA05120.1 - 0.0043 16.2 0.5 0.0075 15.4 0.4 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_14 PF13173.1 EPA05120.1 - 0.0046 16.8 0.3 0.011 15.6 0.1 1.8 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 EPA05120.1 - 0.0063 15.7 0.0 0.0098 15.0 0.0 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EPA05120.1 - 0.011 15.4 0.1 0.023 14.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_10 PF12846.2 EPA05120.1 - 0.012 15.0 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Zeta_toxin PF06414.7 EPA05120.1 - 0.013 14.6 0.1 0.025 13.6 0.0 1.6 1 1 0 1 1 1 0 Zeta toxin AAA_24 PF13479.1 EPA05120.1 - 0.013 15.0 2.1 0.036 13.6 1.5 2.0 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 EPA05120.1 - 0.014 14.8 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Ras PF00071.17 EPA05120.1 - 0.017 14.5 0.4 0.035 13.5 0.2 1.6 2 0 0 2 2 1 0 Ras family ArgK PF03308.11 EPA05120.1 - 0.017 13.8 0.2 0.031 13.0 0.1 1.3 1 0 0 1 1 1 0 ArgK protein PIF1 PF05970.9 EPA05120.1 - 0.046 12.6 0.0 0.067 12.1 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase SRPRB PF09439.5 EPA05120.1 - 0.051 12.8 0.0 0.077 12.2 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Thymidylate_kin PF02223.12 EPA05120.1 - 0.058 12.7 0.3 0.15 11.4 0.2 2.1 1 1 0 1 1 1 0 Thymidylate kinase NB-ARC PF00931.17 EPA05120.1 - 0.069 11.9 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain PduV-EutP PF10662.4 EPA05120.1 - 0.088 12.3 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation UPF0079 PF02367.12 EPA05120.1 - 0.12 11.9 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 POR_N PF01855.14 EPA05122.1 - 1.3e-55 188.3 0.0 1.9e-55 187.8 0.0 1.2 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg POR PF01558.13 EPA05122.1 - 1.3e-26 93.5 0.0 2.6e-26 92.5 0.0 1.5 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase Transketolase_C PF02780.15 EPA05122.1 - 3.2e-06 27.0 0.0 7.4e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_N PF02776.13 EPA05122.1 - 0.076 12.5 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TBP PF00352.16 EPA05123.1 - 8.7e-61 201.2 0.1 5.7e-30 102.5 0.0 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 EPA05123.1 - 3.3e-06 27.0 0.0 0.0071 16.3 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) FlgH PF02107.11 EPA05123.1 - 0.03 13.9 0.1 0.049 13.1 0.1 1.4 1 0 0 1 1 1 0 Flagellar L-ring protein Queuosine_synth PF02547.10 EPA05123.1 - 0.076 11.7 0.5 1.2 7.7 0.1 2.0 1 1 0 2 2 2 0 Queuosine biosynthesis protein DUF1133 PF06576.6 EPA05123.1 - 0.11 11.6 0.2 0.19 10.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1133) SecY PF00344.15 EPA05124.1 - 1.6e-82 277.1 20.0 2.1e-82 276.8 13.8 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 EPA05124.1 - 3.5e-11 42.4 0.6 1.1e-10 40.8 0.4 1.9 1 0 0 1 1 1 1 Plug domain of Sec61p PSI_PsaJ PF01701.13 EPA05124.1 - 0.19 11.5 6.7 19 5.1 0.0 4.1 3 0 0 3 3 3 0 Photosystem I reaction centre subunit IX / PsaJ TPP_enzyme_C PF02775.16 EPA05125.1 - 5.9e-29 100.6 0.2 9.7e-29 99.9 0.1 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PFO_beta_C PF12367.3 EPA05125.1 - 4.4e-08 32.9 0.1 0.00057 19.7 0.0 2.7 2 1 0 2 2 2 2 Pyruvate ferredoxin oxidoreductase beta subunit C terminal Ribosomal_L18e PF00828.14 EPA05126.1 - 8e-23 81.2 0.1 1e-22 80.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 OTCace_N PF02729.16 EPA05127.1 - 2.3e-49 166.7 0.0 3.2e-49 166.2 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 EPA05127.1 - 2.4e-49 167.2 0.0 3.7e-49 166.6 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Sucrose_synth PF00862.14 EPA05127.1 - 0.11 10.3 0.0 0.16 9.8 0.0 1.1 1 0 0 1 1 1 0 Sucrose synthase TFIIB PF00382.14 EPA05128.1 - 2e-33 114.0 5.4 6.5e-18 64.3 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EPA05128.1 - 9.6e-12 44.0 1.2 1.5e-11 43.3 0.8 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_11 PF08279.7 EPA05128.1 - 0.00015 21.3 2.1 0.074 12.7 0.0 3.3 3 0 0 3 3 3 1 HTH domain Cyclin_C PF02984.14 EPA05128.1 - 0.00038 20.3 0.1 1.6 8.6 0.0 2.7 3 0 0 3 3 3 2 Cyclin, C-terminal domain Cyclin_N PF00134.18 EPA05128.1 - 0.0028 17.2 0.2 0.13 11.7 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain HTH_23 PF13384.1 EPA05128.1 - 0.0045 16.5 0.7 0.69 9.6 0.0 3.0 3 0 0 3 3 3 1 Homeodomain-like domain HTH_AsnC-type PF13404.1 EPA05128.1 - 0.0068 15.9 0.1 0.31 10.5 0.0 2.5 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain DZR PF12773.2 EPA05128.1 - 0.0072 16.1 0.7 0.015 15.0 0.5 1.5 1 0 0 1 1 1 1 Double zinc ribbon HTH_24 PF13412.1 EPA05128.1 - 0.0091 15.3 0.1 1.7 8.0 0.0 2.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Sigma70_r4_2 PF08281.7 EPA05128.1 - 0.0094 15.3 2.6 0.82 9.1 0.0 2.9 3 0 0 3 3 3 1 Sigma-70, region 4 Sigma70_r4 PF04545.11 EPA05128.1 - 0.012 14.9 0.0 0.36 10.1 0.0 2.9 3 0 0 3 3 3 0 Sigma-70, region 4 zf-ribbon_3 PF13248.1 EPA05128.1 - 0.02 14.0 2.1 0.043 13.0 1.4 1.5 1 0 0 1 1 1 0 zinc-ribbon domain MarR PF01047.17 EPA05128.1 - 0.024 14.3 0.0 0.2 11.3 0.0 2.5 3 0 0 3 3 3 0 MarR family HypA PF01155.14 EPA05128.1 - 0.04 13.6 0.1 0.13 11.9 0.1 1.8 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Peptidase_M13_N PF05649.8 EPA05128.1 - 0.044 12.8 1.8 0.86 8.5 0.2 2.3 2 1 0 2 2 2 0 Peptidase family M13 DUF294_C PF10335.4 EPA05128.1 - 0.048 13.3 0.2 9.3 5.8 0.0 2.3 2 0 0 2 2 2 0 Putative nucleotidyltransferase substrate binding domain A2L_zn_ribbon PF08792.5 EPA05128.1 - 0.059 12.8 2.7 0.12 11.8 1.9 1.4 1 0 0 1 1 1 0 A2L zinc ribbon domain Phage_terminase PF10668.4 EPA05128.1 - 0.092 12.5 0.1 12 5.7 0.0 3.2 3 0 0 3 3 3 0 Phage terminase small subunit zinc_ribbon_2 PF13240.1 EPA05128.1 - 0.15 11.5 4.3 0.61 9.6 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain HTH_38 PF13936.1 EPA05128.1 - 0.23 11.0 1.9 4.2 6.9 0.0 3.2 4 0 0 4 4 4 0 Helix-turn-helix domain ChuX_HutX PF06228.8 EPA05129.1 - 8.5e-08 31.6 0.1 1e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Haem utilisation ChuX/HutX HemS PF05171.7 EPA05129.1 - 4.4e-07 29.7 0.1 5.6e-07 29.4 0.1 1.1 1 0 0 1 1 1 1 Haemin-degrading HemS.ChuX domain F420_ligase PF01996.11 EPA05130.1 - 2.1e-08 33.5 0.0 2.5e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase Ribosomal_L18p PF00861.17 EPA05131.1 - 1.9e-20 73.2 1.4 2.8e-20 72.6 0.9 1.2 1 0 0 1 1 1 1 Ribosomal L18p/L5e family DUF2854 PF11016.3 EPA05132.1 - 0.086 12.3 0.2 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2854) 2-Hacid_dh_C PF02826.14 EPA05133.1 - 1.6e-60 203.2 0.1 2.4e-60 202.7 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EPA05133.1 - 5.9e-33 113.1 0.0 6.7e-33 112.9 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EPA05133.1 - 1.2e-06 28.4 0.2 2.3e-06 27.5 0.2 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.7 EPA05133.1 - 1.5e-06 27.6 0.5 3.1e-06 26.6 0.1 1.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.12 EPA05133.1 - 0.0005 20.4 0.1 0.0029 18.0 0.0 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.12 EPA05133.1 - 0.018 13.9 0.7 0.027 13.3 0.5 1.2 1 0 0 1 1 1 0 Prephenate dehydrogenase TrkA_N PF02254.13 EPA05133.1 - 0.023 14.7 0.0 0.18 11.8 0.0 2.2 2 0 0 2 2 2 0 TrkA-N domain AdoHcyase_NAD PF00670.16 EPA05133.1 - 0.046 13.5 0.2 0.083 12.7 0.2 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF106 PF01956.11 EPA05134.1 - 9.1e-15 54.5 13.6 4.5e-14 52.3 9.4 1.8 1 1 0 1 1 1 1 Integral membrane protein DUF106 DUF2207 PF09972.4 EPA05134.1 - 0.017 13.7 0.1 0.02 13.4 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2208 PF09973.4 EPA05134.1 - 1.1 8.4 8.9 0.038 13.2 2.1 1.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2208) PepSY_TM_2 PF13703.1 EPA05134.1 - 2.3 8.4 5.2 14 5.8 1.9 2.6 2 1 0 2 2 2 0 PepSY-associated TM helix AAA_18 PF13238.1 EPA05135.1 - 6.8e-13 49.0 0.0 1.1e-12 48.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.1 EPA05135.1 - 2.2e-11 44.0 0.0 3.2e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase-like family AAA_17 PF13207.1 EPA05135.1 - 5.1e-11 43.4 0.1 7.5e-11 42.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain SKI PF01202.17 EPA05135.1 - 2.8e-06 27.2 0.5 4.5e-05 23.3 0.3 2.1 1 1 0 1 1 1 1 Shikimate kinase ADK PF00406.17 EPA05135.1 - 1.5e-05 24.8 0.2 5.3e-05 23.1 0.0 1.9 2 1 0 2 2 2 1 Adenylate kinase AAA PF00004.24 EPA05135.1 - 5.1e-05 23.4 0.0 8.3e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EPA05135.1 - 0.0002 21.2 0.1 0.00033 20.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EPA05135.1 - 0.00036 20.4 0.1 0.0014 18.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 EPA05135.1 - 0.00048 20.1 0.0 0.0012 18.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 EPA05135.1 - 0.0011 18.3 0.2 0.0033 16.6 0.1 1.8 1 1 0 1 1 1 1 Chromatin associated protein KTI12 Rad17 PF03215.10 EPA05135.1 - 0.0011 17.8 0.0 0.0011 17.7 0.0 1.2 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein RNA_helicase PF00910.17 EPA05135.1 - 0.0041 17.2 0.0 0.0086 16.2 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Nif11 PF07862.6 EPA05135.1 - 0.0054 16.6 1.3 0.056 13.3 0.0 2.6 3 0 0 3 3 2 1 Nitrogen fixation protein of unknown function AAA_22 PF13401.1 EPA05135.1 - 0.0056 16.8 0.0 0.014 15.5 0.0 1.7 1 1 0 2 2 2 1 AAA domain MobB PF03205.9 EPA05135.1 - 0.012 15.2 0.0 0.026 14.2 0.0 1.6 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.10 EPA05135.1 - 0.015 15.0 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 NTPase RuvB_N PF05496.7 EPA05135.1 - 0.02 13.9 0.1 0.031 13.3 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Guanylate_kin PF00625.16 EPA05135.1 - 0.021 14.2 0.4 0.96 8.8 0.0 2.3 2 0 0 2 2 2 0 Guanylate kinase AAA_19 PF13245.1 EPA05135.1 - 0.021 14.5 0.1 0.046 13.4 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_24 PF13479.1 EPA05135.1 - 0.029 13.9 0.1 0.052 13.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 EPA05135.1 - 0.055 12.5 0.7 0.11 11.5 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin DUF3616 PF12275.3 EPA05135.1 - 0.056 12.4 0.1 0.082 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3616) AAA_16 PF13191.1 EPA05135.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.1 EPA05135.1 - 0.13 11.7 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Trypan_PARP PF05887.6 EPA05136.1 - 0.0072 16.1 17.7 0.0072 16.1 12.2 2.2 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) PBP1_TM PF14812.1 EPA05136.1 - 0.14 12.4 5.4 0.28 11.5 3.8 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BofA PF07441.6 EPA05137.1 - 0.055 13.4 10.1 0.062 13.3 7.0 1.1 1 0 0 1 1 1 0 SigmaK-factor processing regulatory protein BofA SKG6 PF08693.5 EPA05137.1 - 0.27 10.6 0.1 0.27 10.6 0.1 2.3 2 1 0 2 2 2 0 Transmembrane alpha-helix domain 2TM PF13239.1 EPA05137.1 - 2.7 8.1 4.9 2.8 8.0 3.4 1.1 1 0 0 1 1 1 0 2TM domain Pox_A14 PF05767.7 EPA05137.1 - 9.8 6.2 8.4 1.1 9.2 1.5 1.9 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 Cactin_mid PF10312.4 EPA05139.1 - 0.059 12.6 0.1 0.093 11.9 0.1 1.3 1 1 0 1 1 1 0 Conserved mid region of cactin Vip3A_N PF12495.3 EPA05139.1 - 0.085 12.5 0.1 0.095 12.3 0.1 1.0 1 0 0 1 1 1 0 Vegetative insecticide protein 3A N terminal ILVD_EDD PF00920.16 EPA05142.1 - 1.4e-43 149.1 0.0 1.5e-43 149.0 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family DUF1263 PF06882.7 EPA05142.1 - 0.085 12.4 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1263) eRF1_1 PF03463.10 EPA05145.1 - 3.3e-20 72.0 0.5 3.9e-20 71.7 0.3 1.1 1 0 0 1 1 1 1 eRF1 domain 1 UPF0047 PF01894.12 EPA05146.1 - 3.7e-22 78.3 0.1 4.6e-22 78.0 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 Peptidase_M50 PF02163.17 EPA05148.1 - 1.9e-25 88.9 0.0 1e-24 86.5 0.0 2.0 1 1 0 1 1 1 1 Peptidase family M50 PDZ_2 PF13180.1 EPA05148.1 - 5.7e-10 38.9 0.0 1e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 EPA05148.1 - 0.0014 18.7 0.1 0.0028 17.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) ATP_bind_3 PF01171.15 EPA05149.1 - 2.3e-17 63.0 0.0 3.5e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.11 EPA05149.1 - 1.8e-05 23.5 0.0 2.4e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.8 EPA05149.1 - 0.0024 17.1 0.2 0.0065 15.7 0.0 1.8 1 1 1 2 2 2 1 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.14 EPA05149.1 - 0.053 13.3 0.0 0.063 13.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Ribosomal_S14 PF00253.16 EPA05149.1 - 5.2 6.5 7.0 0.42 10.0 0.9 2.1 2 0 0 2 2 2 0 Ribosomal protein S14p/S29e HHH_5 PF14520.1 EPA05151.1 - 5.2e-14 52.1 0.7 8.5e-14 51.4 0.5 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.2 EPA05151.1 - 8.3e-07 28.7 0.1 2.9e-06 27.0 0.1 1.9 1 1 1 2 2 2 1 Helix-hairpin-helix motif DNA_pol_lambd_f PF10391.4 EPA05151.1 - 1.1e-06 28.0 0.0 2.2e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DUF4332 PF14229.1 EPA05151.1 - 0.00036 20.4 0.0 0.00062 19.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) RNA_pol_A_CTD PF03118.10 EPA05151.1 - 0.0011 18.3 0.3 0.0038 16.6 0.1 2.0 2 0 0 2 2 2 1 Bacterial RNA polymerase, alpha chain C terminal domain HHH_8 PF14716.1 EPA05151.1 - 0.007 16.5 0.1 1.3 9.2 0.0 2.3 1 1 1 2 2 2 1 Helix-hairpin-helix domain HHH PF00633.18 EPA05151.1 - 0.01 15.4 0.1 0.12 12.0 0.0 2.7 3 0 0 3 3 3 0 Helix-hairpin-helix motif TfoX_C PF04994.8 EPA05151.1 - 0.047 13.6 0.2 0.13 12.1 0.0 1.9 2 1 0 2 2 2 0 TfoX C-terminal domain Cdd1 PF11731.3 EPA05151.1 - 0.077 12.9 0.1 0.3 11.0 0.0 1.8 1 1 1 2 2 2 0 Pathogenicity locus DUF3701 PF12482.3 EPA05151.1 - 0.096 12.4 0.0 0.26 11.0 0.0 1.8 1 1 1 2 2 2 0 Phage integrase protein HHH_3 PF12836.2 EPA05151.1 - 0.15 11.9 0.3 25 4.8 0.0 2.6 1 1 2 3 3 3 0 Helix-hairpin-helix motif DsbD PF02683.10 EPA05152.1 - 4.6e-10 39.4 8.9 4.6e-10 39.4 6.1 1.8 1 1 1 2 2 2 1 Cytochrome C biogenesis protein transmembrane region DUF1129 PF06570.6 EPA05152.1 - 0.99 8.6 10.1 1.4 8.1 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF2723 PF11028.3 EPA05152.1 - 4.4 6.7 10.1 0.4 10.1 1.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2723) HTH_17 PF12728.2 EPA05153.1 - 9.6e-05 22.5 0.2 0.014 15.6 0.0 3.1 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_11 PF08279.7 EPA05153.1 - 0.00051 19.6 0.0 0.0012 18.4 0.0 1.6 1 0 0 1 1 1 1 HTH domain zf-Di19 PF05605.7 EPA05153.1 - 0.00069 19.6 0.6 0.014 15.5 0.0 2.6 3 0 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.1 EPA05153.1 - 0.003 17.1 0.1 0.0097 15.5 0.0 1.9 2 0 0 2 2 2 1 zinc-finger of a C2HC-type Sgf11 PF08209.6 EPA05153.1 - 0.0047 16.1 1.5 0.0067 15.7 0.0 2.0 2 0 0 2 2 2 1 Sgf11 (transcriptional regulation protein) HTH_36 PF13730.1 EPA05153.1 - 0.053 13.6 0.3 0.12 12.4 0.2 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain FUR PF01475.14 EPA05153.1 - 0.055 13.4 2.1 3.2 7.6 0.1 2.7 2 2 1 3 3 3 0 Ferric uptake regulator family zf-BED PF02892.10 EPA05153.1 - 0.11 12.2 1.2 1.7 8.5 0.0 2.7 2 0 0 2 2 2 0 BED zinc finger TrmB PF01978.14 EPA05153.1 - 0.14 11.8 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_22 PF13309.1 EPA05153.1 - 0.14 11.9 0.2 0.31 10.8 0.2 1.6 1 0 0 1 1 1 0 HTH domain PyrI_C PF02748.10 EPA05153.1 - 0.31 10.5 3.4 0.5 9.8 0.0 2.4 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Pterin_bind PF00809.17 EPA05154.1 - 2e-27 95.9 0.4 6.5e-27 94.2 0.3 1.7 1 1 0 1 1 1 1 Pterin binding enzyme Pterin_bind PF00809.17 EPA05155.1 - 2.2e-28 99.1 0.2 6.4e-28 97.5 0.2 1.7 1 1 0 1 1 1 1 Pterin binding enzyme Radical_SAM PF04055.16 EPA05156.1 - 5.3e-15 55.9 0.2 5.3e-15 55.9 0.1 2.7 3 0 0 3 3 3 1 Radical SAM superfamily Fer4_14 PF13394.1 EPA05156.1 - 1.1e-07 31.8 0.0 1.1e-07 31.8 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 EPA05156.1 - 1.3e-07 31.8 0.0 4.6e-07 30.0 0.0 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain Asn_synthase PF00733.16 EPA05157.1 - 1e-22 80.9 0.0 1.4e-22 80.4 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.12 EPA05157.1 - 4.1e-07 29.1 0.0 6.4e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 NAD synthase QueC PF06508.8 EPA05157.1 - 0.00052 19.3 0.0 0.00092 18.5 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 EPA05157.1 - 0.00074 18.1 0.0 0.0012 17.4 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase ATP_bind_3 PF01171.15 EPA05157.1 - 0.003 17.0 0.0 0.0063 16.0 0.0 1.5 1 0 0 1 1 1 1 PP-loop family UDPG_MGDP_dh_N PF03721.9 EPA05158.1 - 4.1e-39 133.8 0.0 9.8e-39 132.6 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.10 EPA05158.1 - 2.9e-22 78.8 0.0 1.2e-21 76.8 0.0 2.0 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.14 EPA05158.1 - 2.8e-21 75.5 0.1 5.8e-21 74.5 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_binding_2 PF03446.10 EPA05158.1 - 5.4e-06 26.3 0.0 3.1e-05 23.8 0.0 2.4 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 EPA05158.1 - 2.3e-05 23.6 0.0 1.3 8.1 0.0 3.4 3 0 0 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 EPA05158.1 - 0.0031 17.2 0.0 0.033 13.9 0.0 2.6 2 1 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ThiF PF00899.16 EPA05158.1 - 0.012 15.4 0.1 0.047 13.5 0.1 2.1 1 1 0 1 1 1 0 ThiF family 3HCDH_N PF02737.13 EPA05158.1 - 0.019 14.6 0.0 0.043 13.4 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.22 EPA05158.1 - 0.026 14.9 0.7 19 5.7 0.0 3.7 5 0 0 5 5 5 0 Pyridine nucleotide-disulphide oxidoreductase F420_oxidored PF03807.12 EPA05158.1 - 0.098 13.0 1.5 3.3 8.2 0.5 3.2 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent TrmB PF01978.14 EPA05159.1 - 5e-21 74.1 0.1 1.7e-20 72.4 0.0 2.0 2 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.3 EPA05159.1 - 3e-07 29.6 0.0 3.6e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB HTH_IclR PF09339.5 EPA05159.1 - 6.5e-05 22.4 0.0 0.00031 20.2 0.0 2.1 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR PF01047.17 EPA05159.1 - 0.00024 20.7 0.0 0.001 18.7 0.0 2.1 1 1 1 2 2 2 1 MarR family HTH_24 PF13412.1 EPA05159.1 - 0.0023 17.2 0.0 0.0057 16.0 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_27 PF13463.1 EPA05159.1 - 0.0039 17.4 0.0 0.012 15.9 0.0 1.9 1 0 0 1 1 1 1 Winged helix DNA-binding domain Penicillinase_R PF03965.11 EPA05159.1 - 0.0056 16.7 0.1 0.038 14.0 0.0 2.1 2 0 0 2 2 2 1 Penicillinase repressor YflT PF11181.3 EPA05159.1 - 0.039 14.1 0.2 2.9 8.0 0.0 2.9 2 1 0 3 3 3 0 Heat induced stress protein YflT Rrf2 PF02082.15 EPA05159.1 - 0.045 13.8 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 Transcriptional regulator PLDc_2 PF13091.1 EPA05159.1 - 0.083 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 PLD-like domain MarR_2 PF12802.2 EPA05159.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 MarR family Fe_dep_repress PF01325.14 EPA05160.1 - 9.9e-12 44.6 0.1 1.3e-11 44.2 0.1 1.1 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain MarR PF01047.17 EPA05160.1 - 0.0078 15.9 0.0 0.0094 15.6 0.0 1.1 1 0 0 1 1 1 1 MarR family NLPC_P60 PF00877.14 EPA05160.1 - 0.021 14.6 0.0 0.023 14.5 0.0 1.1 1 0 0 1 1 1 0 NlpC/P60 family ANT PF03374.9 EPA05160.1 - 0.03 14.3 0.0 0.031 14.3 0.0 1.2 1 0 0 1 1 1 0 Phage antirepressor protein KilAC domain MarR_2 PF12802.2 EPA05160.1 - 0.034 13.8 0.0 0.041 13.5 0.0 1.1 1 0 0 1 1 1 0 MarR family HTH_27 PF13463.1 EPA05160.1 - 0.04 14.2 0.0 0.053 13.8 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain TFIIE_beta PF02186.10 EPA05160.1 - 0.085 12.8 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 TFIIE beta subunit core domain HTH_37 PF13744.1 EPA05160.1 - 0.11 12.3 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain IF2_N PF04760.10 EPA05160.1 - 0.13 11.9 0.1 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Glyco_trans_1_2 PF13524.1 EPA05161.1 - 0.041 14.1 0.0 0.043 14.0 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferases group 1 Methyltransf_21 PF05050.7 EPA05162.1 - 1.8e-25 89.8 0.5 2.4e-25 89.4 0.4 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_18 PF12847.2 EPA05162.1 - 4e-10 40.2 0.0 7.2e-10 39.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 EPA05162.1 - 2.3e-09 37.1 1.1 4e-09 36.3 0.8 1.6 1 1 0 1 1 1 1 Met-10+ like-protein V_cholerae_RfbT PF05575.6 EPA05162.1 - 5e-07 29.0 3.6 6.7e-07 28.6 2.5 1.2 1 0 0 1 1 1 1 Vibrio cholerae RfbT protein Methyltransf_31 PF13847.1 EPA05162.1 - 4e-06 26.5 0.7 6.8e-06 25.7 0.5 1.6 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EPA05162.1 - 1.7e-05 24.4 0.0 2.7e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.14 EPA05162.1 - 0.0029 17.6 0.0 0.0037 17.2 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase PrmA PF06325.8 EPA05162.1 - 0.014 14.5 0.3 0.022 13.9 0.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF2682 PF10909.3 EPA05162.1 - 0.021 15.0 2.5 6.1 7.2 0.1 3.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2682) Methyltransf_3 PF01596.12 EPA05162.1 - 0.035 13.1 0.0 0.11 11.5 0.0 1.8 1 1 0 1 1 1 0 O-methyltransferase Epimerase_Csub PF13950.1 EPA05163.1 - 0.0031 17.4 0.0 0.0031 17.4 0.0 1.1 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit Epimerase PF01370.16 EPA05164.1 - 1.8e-44 151.9 0.0 2.1e-44 151.7 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EPA05164.1 - 9e-27 93.4 0.1 1.2e-26 93.1 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EPA05164.1 - 1.1e-22 80.3 0.0 1.2e-22 80.1 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 EPA05164.1 - 1e-16 60.6 0.1 7.6e-16 57.8 0.1 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 EPA05164.1 - 3e-16 59.0 0.1 2.9e-11 42.7 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.1 EPA05164.1 - 3.8e-10 40.0 0.0 4.3e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 EPA05164.1 - 9.9e-10 38.5 0.0 1.5e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EPA05164.1 - 7.3e-07 29.0 0.0 1.8e-06 27.7 0.0 1.6 1 1 0 1 1 1 1 KR domain NmrA PF05368.8 EPA05164.1 - 1.4e-06 27.7 0.2 1.9e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family Shikimate_DH PF01488.15 EPA05164.1 - 0.0011 19.1 0.0 0.0025 17.9 0.0 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Saccharop_dh PF03435.13 EPA05164.1 - 0.003 16.6 0.0 0.0046 15.9 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase TrkA_N PF02254.13 EPA05164.1 - 0.0079 16.1 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain DapB_N PF01113.15 EPA05164.1 - 0.045 13.6 0.4 0.17 11.7 0.3 1.9 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Stap_Strp_toxin PF01123.15 EPA05164.1 - 0.33 11.4 4.8 16 6.0 2.0 2.9 1 1 1 2 2 2 0 Staphylococcal/Streptococcal toxin, OB-fold domain Glyco_trans_4_2 PF13477.1 EPA05165.1 - 1.6e-08 34.4 0.4 1.5e-06 28.1 0.1 2.7 1 1 1 2 2 2 1 Glycosyl transferase 4-like Glyco_trans_4_4 PF13579.1 EPA05165.1 - 0.0004 20.5 0.0 0.0013 18.9 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain PIGA PF08288.7 EPA05165.1 - 0.00056 20.2 0.6 0.0046 17.3 0.1 2.2 1 1 1 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.1 EPA05165.1 - 0.0086 15.8 0.3 0.017 14.8 0.2 1.6 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Dynactin_p22 PF07426.6 EPA05165.1 - 0.045 13.0 0.1 0.15 11.3 0.0 1.8 2 0 0 2 2 2 0 Dynactin subunit p22 Glycos_transf_1 PF00534.15 EPA05165.1 - 0.11 11.8 0.3 11 5.3 0.0 2.5 2 1 1 3 3 3 0 Glycosyl transferases group 1 S-AdoMet_synt_C PF02773.11 EPA05166.1 - 1.7e-69 231.8 0.0 2.9e-69 231.1 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 EPA05166.1 - 5.6e-36 123.1 0.5 9.7e-36 122.3 0.3 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain Mt_ATP-synt_B PF05405.9 EPA05166.1 - 0.079 12.4 0.2 0.12 11.8 0.2 1.2 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) NAD_binding_10 PF13460.1 EPA05167.1 - 2.6e-16 60.1 0.0 3.4e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EPA05167.1 - 7.5e-14 51.7 0.1 3.6e-12 46.2 0.0 2.4 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EPA05167.1 - 6.1e-10 38.2 0.6 7.8e-07 28.0 0.1 2.4 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EPA05167.1 - 1.4e-07 30.6 0.0 0.0014 17.5 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain NAD_binding_4 PF07993.7 EPA05167.1 - 1e-05 24.5 0.1 0.037 12.9 0.0 2.9 1 1 2 3 3 3 2 Male sterility protein DUF1699 PF08004.6 EPA05167.1 - 0.0012 18.3 0.8 0.018 14.5 0.1 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF1699) DDE_Tnp_1_3 PF13612.1 EPA05167.1 - 0.0039 16.9 0.3 0.0078 15.9 0.2 1.6 1 0 0 1 1 1 1 Transposase DDE domain PAC2 PF09754.4 EPA05167.1 - 0.082 12.7 0.0 0.19 11.5 0.0 1.6 2 0 0 2 2 2 0 PAC2 family Shikimate_DH PF01488.15 EPA05167.1 - 0.088 12.9 0.3 0.17 11.9 0.2 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CbiD PF01888.12 EPA05168.1 - 1.2e-72 244.0 1.3 1.4e-72 243.8 0.9 1.0 1 0 0 1 1 1 1 CbiD DUF3042 PF11240.3 EPA05168.1 - 0.034 13.9 2.2 0.06 13.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) Transaldolase PF00923.14 EPA05169.1 - 1.2e-09 37.7 0.0 1.3e-09 37.6 0.0 1.0 1 0 0 1 1 1 1 Transaldolase Transketolase_C PF02780.15 EPA05170.1 - 1.3e-29 102.6 0.0 2e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.19 EPA05170.1 - 5.3e-14 52.1 0.0 8.2e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DUF4493 PF14900.1 EPA05170.1 - 0.13 11.9 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4493) PRA-CH PF01502.13 EPA05171.1 - 2.8e-35 119.7 0.1 3.5e-35 119.4 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase DUF3821 PF12863.2 EPA05171.1 - 0.14 11.8 0.5 0.17 11.5 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3821) His_biosynth PF00977.16 EPA05172.1 - 5.3e-59 199.2 0.9 6.1e-59 199.0 0.7 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Dus PF01207.12 EPA05172.1 - 2.3e-08 33.2 0.2 0.0016 17.3 0.0 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) TMP-TENI PF02581.12 EPA05172.1 - 5.9e-05 22.2 0.1 0.011 14.8 0.0 2.2 2 0 0 2 2 2 2 Thiamine monophosphate synthase/TENI DHO_dh PF01180.16 EPA05172.1 - 0.00012 21.1 0.1 0.017 14.0 0.0 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase ThiG PF05690.9 EPA05172.1 - 0.00013 21.1 0.5 0.062 12.3 0.0 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG NMO PF03060.10 EPA05172.1 - 0.00017 20.8 0.2 0.025 13.7 0.0 2.1 2 0 0 2 2 2 2 Nitronate monooxygenase PcrB PF01884.12 EPA05172.1 - 0.0002 20.6 0.1 0.0002 20.6 0.1 2.3 2 1 0 3 3 3 1 PcrB family Trp_syntA PF00290.15 EPA05172.1 - 0.044 12.3 0.4 0.1 11.1 0.0 1.7 2 0 0 2 2 2 0 Tryptophan synthase alpha chain IMPDH PF00478.20 EPA05172.1 - 0.061 12.1 1.3 3 6.6 0.1 2.1 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain PALP PF00291.20 EPA05175.1 - 2e-45 155.3 1.1 2.3e-45 155.1 0.7 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACP_syn_III_C PF08541.5 EPA05175.1 - 0.013 15.5 0.1 0.048 13.6 0.0 2.0 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ThiF PF00899.16 EPA05176.1 - 5.4e-45 152.5 1.5 8.5e-45 151.9 1.0 1.3 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 EPA05176.1 - 1.3e-17 63.1 0.1 2.6e-17 62.1 0.1 1.5 1 0 0 1 1 1 1 MoeZ/MoeB domain ThiS PF02597.15 EPA05176.1 - 1.8e-08 34.6 0.0 6.1e-08 32.9 0.0 1.9 1 0 0 1 1 1 1 ThiS family Shikimate_DH PF01488.15 EPA05176.1 - 0.0037 17.3 0.1 0.009 16.1 0.1 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 EPA05176.1 - 0.046 12.8 0.1 0.079 12.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RIG-I_C-RD PF11648.3 EPA05177.1 - 0.15 11.9 0.5 0.36 10.7 0.3 1.6 1 1 1 2 2 2 0 C-terminal domain of RIG-I bact-PGI_C PF10432.4 EPA05179.1 - 5.5e-36 123.6 0.1 1.2e-35 122.5 0.1 1.5 1 0 0 1 1 1 1 Bacterial phospho-glucose isomerase C-terminal region SIS PF01380.17 EPA05179.1 - 6e-05 22.6 0.1 0.00012 21.7 0.1 1.5 1 0 0 1 1 1 1 SIS domain Glyco_trans_4_2 PF13477.1 EPA05179.1 - 0.011 15.5 6.1 0.11 12.2 0.5 3.3 2 1 0 2 2 2 0 Glycosyl transferase 4-like ApbA PF02558.11 EPA05179.1 - 0.069 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ABC2_membrane_5 PF13346.1 EPA05180.1 - 0.059 12.6 0.3 0.068 12.4 0.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein 7TM-7TMR_HD PF07698.6 EPA05180.1 - 0.082 12.3 0.1 0.096 12.1 0.1 1.1 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase Ycf9 PF01737.12 EPA05180.1 - 0.24 10.8 1.2 0.56 9.6 0.8 1.7 1 1 1 2 2 2 0 YCF9 UPF0104 PF03706.8 EPA05181.1 - 0.071 12.3 0.0 0.075 12.2 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0104) AIPR PF10592.4 EPA05182.1 - 5.5e-66 222.9 8.1 6.9e-66 222.6 5.6 1.1 1 0 0 1 1 1 1 AIPR protein RGS PF00615.14 EPA05182.1 - 0.042 13.9 0.7 0.15 12.2 0.0 2.2 2 1 0 2 2 2 0 Regulator of G protein signaling domain HTH_45 PF14947.1 EPA05183.1 - 4.5e-16 58.4 0.3 5.2e-16 58.2 0.2 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.1 EPA05183.1 - 0.0015 18.1 0.2 0.0015 18.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) PadR PF03551.9 EPA05183.1 - 0.0025 17.5 0.1 0.0033 17.1 0.1 1.2 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_34 PF13601.1 EPA05183.1 - 0.0037 17.2 0.2 0.0047 16.9 0.2 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain RNA_pol_Rpc34 PF05158.7 EPA05183.1 - 0.0044 16.2 0.1 0.0055 15.9 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit Mrr_N PF14338.1 EPA05183.1 - 0.0055 16.7 0.0 0.0074 16.3 0.0 1.3 1 0 0 1 1 1 1 Mrr N-terminal domain Rrf2 PF02082.15 EPA05183.1 - 0.022 14.8 0.1 0.043 13.9 0.1 1.5 2 0 0 2 2 2 0 Transcriptional regulator RPA_C PF08784.6 EPA05183.1 - 0.026 14.9 0.0 0.034 14.5 0.0 1.2 1 0 0 1 1 1 0 Replication protein A C terminal PilN PF05137.8 EPA05183.1 - 0.033 13.9 0.2 0.048 13.5 0.1 1.5 1 1 0 1 1 1 0 Fimbrial assembly protein (PilN) Ribosomal_S19e PF01090.14 EPA05183.1 - 0.038 13.4 0.0 0.04 13.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein S19e TrmB PF01978.14 EPA05183.1 - 0.059 13.0 0.0 0.086 12.5 0.0 1.3 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB YjcQ PF09639.5 EPA05183.1 - 0.072 13.1 0.1 0.099 12.7 0.0 1.3 1 0 0 1 1 1 0 YjcQ protein DUF4468 PF14730.1 EPA05183.1 - 0.11 12.2 0.1 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold MarR PF01047.17 EPA05183.1 - 0.11 12.1 0.1 0.21 11.3 0.1 1.4 1 0 0 1 1 1 0 MarR family HTH_26 PF13443.1 EPA05183.1 - 0.13 12.4 0.1 0.18 12.0 0.1 1.3 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain DUF4475 PF14753.1 EPA05184.1 - 0.017 14.6 1.0 0.025 14.1 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4475) DUF458 PF04308.7 EPA05184.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF458) DUF4428 PF14471.1 EPA05185.1 - 0.0046 16.6 2.8 0.01 15.5 2.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4428) PDH PF02153.12 EPA05186.1 - 3.6e-25 88.3 0.2 4.2e-25 88.1 0.2 1.1 1 0 0 1 1 1 1 Prephenate dehydrogenase 2-Hacid_dh_C PF02826.14 EPA05186.1 - 4e-06 26.1 0.1 7.8e-06 25.1 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 EPA05186.1 - 1e-05 25.4 0.1 2.8e-05 23.9 0.0 1.8 2 1 1 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 EPA05186.1 - 0.00045 19.9 0.2 0.0014 18.3 0.0 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.12 EPA05186.1 - 0.0011 19.4 1.2 0.0078 16.6 0.0 2.9 3 2 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.18 EPA05186.1 - 0.0017 18.0 0.7 0.65 9.7 0.1 3.0 2 1 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Phage-tail_1 PF09097.5 EPA05186.1 - 0.017 14.6 0.8 0.044 13.3 0.3 1.7 1 1 1 2 2 2 0 Baseplate structural protein, domain 1 ThiF PF00899.16 EPA05186.1 - 0.019 14.7 0.2 6.5 6.5 0.0 3.0 2 1 1 3 3 3 0 ThiF family IlvN PF07991.7 EPA05186.1 - 0.019 14.3 0.1 0.056 12.8 0.0 1.8 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain NmrA PF05368.8 EPA05186.1 - 0.048 12.9 1.0 0.51 9.5 0.0 2.6 3 1 0 3 3 3 0 NmrA-like family NAD_binding_10 PF13460.1 EPA05186.1 - 0.076 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 NADH(P)-binding DapB_N PF01113.15 EPA05186.1 - 0.13 12.2 1.0 0.32 10.8 0.0 2.2 3 1 1 4 4 4 0 Dihydrodipicolinate reductase, N-terminus DUF155 PF02582.9 EPA05186.1 - 0.42 10.5 4.1 2.4 8.0 0.3 2.4 1 1 1 2 2 2 0 Uncharacterised ACR, YagE family COG1723 ThiC PF01964.13 EPA05187.1 - 1.6e-175 583.7 0.6 1.8e-175 583.5 0.4 1.0 1 0 0 1 1 1 1 ThiC family NUDIX PF00293.23 EPA05188.1 - 1.9e-12 46.9 0.0 2.1e-12 46.8 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.1 EPA05188.1 - 0.00013 21.3 0.2 0.0003 20.2 0.1 1.6 1 1 0 1 1 1 1 NUDIX domain Aminotran_1_2 PF00155.16 EPA05189.1 - 4.2e-62 210.1 0.0 6.1e-62 209.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II CM_2 PF01817.16 EPA05189.1 - 3.5e-10 39.8 0.9 9.1e-10 38.5 0.6 1.8 1 0 0 1 1 1 1 Chorismate mutase type II Aminotran_5 PF00266.14 EPA05189.1 - 3.8e-06 25.9 0.0 7e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EPA05189.1 - 2.7e-05 22.6 0.0 3.8e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 EPA05189.1 - 0.002 17.2 0.0 0.0026 16.8 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family DUF1396 PF07161.8 EPA05189.1 - 0.017 14.8 0.1 0.058 13.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1396) PI3K_p85B PF02192.11 EPA05189.1 - 0.076 12.4 0.3 1.6 8.2 0.0 2.7 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain Chorismate_synt PF01264.16 EPA05190.1 - 5.1e-66 222.5 0.2 5.7e-66 222.3 0.1 1.0 1 0 0 1 1 1 1 Chorismate synthase EAF PF09816.4 EPA05190.1 - 0.097 12.6 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase II transcription elongation factor DUF3810 PF12725.2 EPA05191.1 - 0.16 10.8 0.4 0.16 10.7 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) TusA PF01206.12 EPA05193.1 - 3.4e-22 77.8 0.0 3.8e-22 77.6 0.0 1.0 1 0 0 1 1 1 1 Sulfurtransferase TusA PALP PF00291.20 EPA05194.1 - 4.2e-58 197.0 0.0 5.1e-58 196.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Trypsin_2 PF13365.1 EPA05195.1 - 8e-21 74.2 0.4 1.6e-20 73.3 0.3 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 EPA05195.1 - 4.8e-15 55.7 0.4 9.6e-15 54.7 0.3 1.5 1 1 0 1 1 1 1 Trypsin PDZ_2 PF13180.1 EPA05195.1 - 2.5e-14 52.9 0.3 2.5e-14 52.9 0.2 2.1 3 0 0 3 3 3 1 PDZ domain PDZ PF00595.19 EPA05195.1 - 0.0055 16.8 1.7 7.6 6.7 0.7 3.6 2 1 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) Peptidase_S29 PF02907.10 EPA05195.1 - 0.0075 15.7 0.0 0.023 14.2 0.0 1.9 1 0 0 1 1 1 1 Hepatitis C virus NS3 protease Peptidase_S46 PF10459.4 EPA05195.1 - 0.19 10.1 3.2 0.075 11.4 0.5 1.6 2 0 0 2 2 2 0 Peptidase S46 CbiA PF01656.18 EPA05196.1 - 1.2e-25 90.0 0.0 1.7e-25 89.5 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.1 EPA05196.1 - 1.9e-12 47.2 0.5 2.5e-06 27.2 0.0 2.1 1 1 1 2 2 2 2 AAA domain YhjQ PF06564.7 EPA05196.1 - 0.0071 15.7 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 YhjQ protein CTP_synth_N PF06418.9 EPA05196.1 - 0.012 14.7 0.0 0.028 13.5 0.0 1.5 1 0 0 1 1 1 0 CTP synthase N-terminus IstB_IS21 PF01695.12 EPA05196.1 - 0.048 13.0 0.2 0.14 11.5 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_23 PF13476.1 EPA05196.1 - 0.27 11.5 3.7 1.3 9.3 2.6 1.9 1 1 0 1 1 1 0 AAA domain STT3 PF02516.9 EPA05197.1 - 5.5e-35 121.2 38.2 9e-35 120.5 26.5 1.4 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.1 EPA05197.1 - 2.8e-05 24.0 16.1 2.8e-05 24.0 11.2 3.6 2 2 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase EIF_2_alpha PF07541.7 EPA05198.1 - 8e-24 83.5 1.3 1.5e-23 82.7 0.4 1.9 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 EPA05198.1 - 7.9e-13 48.2 0.2 6.1e-12 45.4 0.1 2.4 2 0 0 2 2 2 1 S1 RNA binding domain DUF3782 PF12644.2 EPA05198.1 - 0.027 14.2 0.0 0.34 10.7 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3782) EXOSC1 PF10447.4 EPA05198.1 - 0.044 13.7 0.6 0.3 11.0 0.1 2.5 2 1 0 2 2 2 0 Exosome component EXOSC1/CSL4 MBT PF02820.13 EPA05198.1 - 0.13 12.1 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 mbt repeat CobA_CobO_BtuR PF02572.10 EPA05199.1 - 1.3e-60 203.9 0.2 1.4e-60 203.8 0.1 1.0 1 0 0 1 1 1 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP AAA_14 PF13173.1 EPA05199.1 - 0.0014 18.5 0.3 0.0026 17.6 0.0 1.5 2 0 0 2 2 2 1 AAA domain Response_reg PF00072.19 EPA05199.1 - 0.06 13.3 0.2 0.089 12.8 0.1 1.3 1 0 0 1 1 1 0 Response regulator receiver domain DUF4514 PF14986.1 EPA05199.1 - 0.064 13.0 0.2 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4514) DUF1360 PF07098.6 EPA05203.1 - 0.039 13.6 0.3 0.15 11.8 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1360) ETRAMP PF09716.5 EPA05203.1 - 5.9 6.9 6.3 0.63 10.0 0.4 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) TrkH PF02386.11 EPA05204.1 - 2.2e-25 89.0 37.0 1.4e-21 76.4 19.7 3.1 1 1 1 2 2 2 2 Cation transport protein Copper-bind PF00127.15 EPA05206.1 - 2.4e-10 40.5 0.1 3.8e-10 39.8 0.1 1.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 EPA05206.1 - 4.3e-06 26.5 1.4 0.0003 20.6 0.2 2.2 1 1 1 2 2 2 2 Cupredoxin-like domain SoxE PF06525.6 EPA05206.1 - 0.00016 21.0 0.1 0.00023 20.5 0.1 1.3 1 1 0 1 1 1 1 Sulfocyanin (SoxE) Thioredoxin PF00085.15 EPA05206.1 - 0.1 12.2 0.2 0.18 11.5 0.1 1.4 1 1 0 1 1 1 0 Thioredoxin Cu-oxidase_2 PF07731.9 EPA05206.1 - 0.13 11.7 0.0 0.3 10.5 0.0 1.6 1 0 0 1 1 1 0 Multicopper oxidase PP-binding PF00550.20 EPA05207.1 - 2e-05 24.7 0.0 2.4e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site DNA_pol3_a_NI PF14480.1 EPA05207.1 - 0.047 13.3 1.0 0.082 12.5 0.7 1.5 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus I Acid_PPase PF12689.2 EPA05208.1 - 3.7e-07 29.9 0.2 0.00024 20.7 0.0 2.6 2 0 0 2 2 2 2 Acid Phosphatase Acetyltransf_10 PF13673.1 EPA05208.1 - 4.7e-07 29.9 0.0 9.1e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain NIF PF03031.13 EPA05208.1 - 2.2e-05 24.1 0.0 8.2e-05 22.3 0.0 2.0 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Corona_S2 PF01601.11 EPA05208.1 - 0.0083 14.2 0.1 0.017 13.2 0.1 1.4 1 0 0 1 1 1 1 Coronavirus S2 glycoprotein DLD PF14878.1 EPA05208.1 - 0.34 11.0 2.6 0.61 10.2 1.1 2.0 2 1 0 2 2 2 0 Death-like domain of SPT6 Polysacc_synt_3 PF13440.1 EPA05209.1 - 7.9e-17 61.5 36.6 2.3e-14 53.4 15.8 2.0 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein Polysacc_synt PF01943.12 EPA05209.1 - 1.4e-05 24.4 55.4 4.9e-05 22.7 25.9 2.7 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.1 EPA05209.1 - 1.2 8.9 46.1 0.14 11.9 5.1 4.0 2 1 2 4 4 4 0 Polysaccharide biosynthesis C-terminal domain Glyco_trans_1_2 PF13524.1 EPA05210.1 - 5e-05 23.4 0.0 9.2e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 HTH_11 PF08279.7 EPA05211.1 - 0.00022 20.8 0.0 0.00068 19.2 0.0 1.8 1 0 0 1 1 1 1 HTH domain HTH_30 PF13556.1 EPA05211.1 - 0.021 14.3 0.0 0.078 12.5 0.0 1.9 2 0 0 2 2 2 0 PucR C-terminal helix-turn-helix domain HTH_38 PF13936.1 EPA05211.1 - 0.047 13.2 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain bact-PGI_C PF10432.4 EPA05212.1 - 2.8e-38 131.0 0.0 5e-38 130.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial phospho-glucose isomerase C-terminal region SIS PF01380.17 EPA05212.1 - 7.1e-09 35.3 0.1 1.5e-08 34.3 0.1 1.6 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.1 EPA05212.1 - 0.33 10.6 2.3 0.65 9.7 0.1 2.4 2 1 0 2 2 2 0 SIS domain CTP_transf_3 PF02348.14 EPA05213.1 - 7.2e-30 104.2 1.7 8.9e-30 103.9 1.2 1.1 1 0 0 1 1 1 1 Cytidylyltransferase Agenet PF05641.7 EPA05213.1 - 0.043 13.9 0.3 0.13 12.4 0.2 1.9 1 1 0 1 1 1 0 Agenet domain NTP_transf_3 PF12804.2 EPA05213.1 - 0.053 13.5 0.0 0.13 12.3 0.0 1.6 2 0 0 2 2 2 0 MobA-like NTP transferase domain B3 PF02362.16 EPA05214.1 - 0.0081 15.7 0.2 0.021 14.4 0.0 1.8 2 0 0 2 2 2 1 B3 DNA binding domain NAD_synthase PF02540.12 EPA05214.1 - 0.1 11.4 0.0 0.18 10.7 0.0 1.4 1 0 0 1 1 1 0 NAD synthase Pox_TAA1 PF03295.9 EPA05214.1 - 0.18 11.4 0.7 4.3 7.0 0.0 3.0 3 0 0 3 3 3 0 Poxvirus trans-activator protein A1 C-terminal Epimerase PF01370.16 EPA05215.1 - 1.6e-51 175.0 0.0 1.9e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EPA05215.1 - 1.1e-21 76.9 0.1 1e-20 73.8 0.1 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.12 EPA05215.1 - 1.4e-20 73.3 0.0 1.9e-20 72.9 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 EPA05215.1 - 3e-19 68.7 0.0 4e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EPA05215.1 - 1.3e-10 40.6 0.0 4.5e-09 35.5 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 EPA05215.1 - 4.2e-07 30.1 0.0 6.5e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EPA05215.1 - 3.3e-06 26.5 0.1 7.4e-06 25.3 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.20 EPA05215.1 - 6.7e-06 26.1 0.0 1.4e-05 25.0 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EPA05215.1 - 0.00015 21.4 0.0 0.0003 20.4 0.0 1.5 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 EPA05215.1 - 0.08 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GMP_synt_C PF00958.17 EPA05216.1 - 2.9e-32 110.2 0.0 7.3e-32 108.9 0.0 1.7 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.23 EPA05216.1 - 4.2e-16 58.9 0.0 6.7e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.12 EPA05216.1 - 1.2e-12 47.2 0.1 3.4e-06 26.1 0.0 2.2 2 0 0 2 2 2 2 NAD synthase ThiI PF02568.9 EPA05216.1 - 5.1e-06 26.0 0.0 0.00064 19.2 0.0 2.3 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.11 EPA05216.1 - 6.9e-05 21.5 0.0 0.0025 16.4 0.0 2.2 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.8 EPA05216.1 - 0.0047 16.2 0.0 0.28 10.4 0.0 2.2 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.16 EPA05216.1 - 0.0074 15.8 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Asparagine synthase Peptidase_C26 PF07722.8 EPA05216.1 - 0.0091 15.4 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 ATP_bind_3 PF01171.15 EPA05216.1 - 0.17 11.3 0.0 0.4 10.1 0.0 1.6 2 0 0 2 2 2 0 PP-loop family CmcI PF04989.7 EPA05217.1 - 1.2e-85 286.0 0.7 1.4e-85 285.8 0.5 1.1 1 0 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_24 PF13578.1 EPA05217.1 - 3.6e-10 40.6 0.0 5.3e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA05217.1 - 0.01 16.4 0.0 0.016 15.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RST PF12174.3 EPA05217.1 - 0.015 15.0 3.5 0.016 14.9 0.8 2.2 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain Mur_ligase_C PF02875.16 EPA05217.1 - 0.016 15.2 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Methyltransf_3 PF01596.12 EPA05217.1 - 0.052 12.5 0.1 0.065 12.2 0.1 1.2 1 0 0 1 1 1 0 O-methyltransferase DNA_pol3_delta PF06144.8 EPA05217.1 - 0.12 11.9 2.8 0.14 11.6 1.2 1.7 1 1 0 1 1 1 0 DNA polymerase III, delta subunit Glycos_transf_2 PF00535.21 EPA05219.1 - 2.6e-27 95.5 0.0 5.5e-27 94.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 EPA05219.1 - 7.9e-20 71.6 0.0 1.1e-19 71.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 EPA05219.1 - 1.8e-07 31.0 0.0 2.8e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_2 PF10111.4 EPA05219.1 - 1.3e-05 24.4 0.5 3.2e-05 23.1 0.3 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_5 PF13712.1 EPA05219.1 - 0.0029 16.9 0.0 1.5 8.0 0.0 2.3 1 1 1 2 2 2 2 Glycosyltransferase like family Glyco_tranf_2_4 PF13704.1 EPA05219.1 - 0.0032 17.7 0.0 0.0099 16.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 EPA05219.1 - 0.029 13.6 0.0 0.058 12.6 0.0 1.5 1 1 0 1 1 1 0 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 EPA05220.1 - 1.6e-23 83.1 0.3 2.7e-23 82.4 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 EPA05220.1 - 5.4e-05 23.1 0.0 6.4e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DUF4319 PF14203.1 EPA05220.1 - 0.012 15.1 0.0 0.53 9.8 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4319) Glyco_tranf_2_4 PF13704.1 EPA05220.1 - 0.017 15.4 0.0 0.03 14.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 PGM_PMM_II PF02879.11 EPA05220.1 - 0.031 14.6 0.1 0.09 13.1 0.1 1.8 1 1 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PIRT PF15099.1 EPA05220.1 - 0.3 10.3 4.7 0.51 9.5 3.2 1.4 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Glycos_transf_1 PF00534.15 EPA05221.1 - 8.8e-27 93.6 0.0 1.5e-26 92.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EPA05221.1 - 3.4e-14 53.1 0.0 6e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 EPA05221.1 - 3.8e-11 43.0 0.0 6.1e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.1 EPA05221.1 - 0.0017 18.5 0.0 0.0035 17.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_3 PF13528.1 EPA05221.1 - 0.065 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 1 Epimerase PF01370.16 EPA05222.1 - 6.7e-08 32.2 0.0 6.7e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EPA05222.1 - 1.5e-05 25.0 0.0 1.6e-05 24.9 0.0 1.0 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EPA05222.1 - 0.00012 21.4 0.0 0.00013 21.3 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 EPA05222.1 - 0.0003 19.7 0.0 0.0003 19.7 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 EPA05222.1 - 0.00049 18.8 0.0 0.00049 18.8 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 EPA05222.1 - 0.0017 17.3 0.0 0.0017 17.3 0.0 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 EPA05222.1 - 0.0025 17.7 0.0 0.0025 17.7 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.7 EPA05222.1 - 0.0038 16.1 0.0 0.0042 16.0 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein DapB_N PF01113.15 EPA05222.1 - 0.0084 16.0 0.0 0.0088 15.9 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Ldh_1_N PF00056.18 EPA05222.1 - 0.061 13.1 0.0 0.062 13.1 0.0 1.1 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Epimerase PF01370.16 EPA05223.1 - 3.4e-32 111.7 0.0 4.4e-32 111.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EPA05223.1 - 7.3e-15 54.6 0.0 4.6e-14 51.9 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 EPA05223.1 - 2.3e-09 36.3 0.0 2.9e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EPA05223.1 - 9.5e-09 34.5 0.0 1.3e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 EPA05223.1 - 2e-07 30.2 0.0 8.2e-07 28.1 0.0 2.0 2 0 0 2 2 2 1 Male sterility protein DUF2079 PF09852.4 EPA05224.1 - 9.9e-12 44.3 17.5 1.5e-11 43.6 12.1 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2079) PMT_2 PF13231.1 EPA05224.1 - 9.3e-11 41.8 13.7 9.3e-11 41.8 9.5 2.9 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT PF02366.13 EPA05224.1 - 0.0013 18.1 9.3 0.0013 18.1 6.4 2.9 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF4014 PF13198.1 EPA05224.1 - 0.046 14.1 0.4 0.046 14.1 0.3 3.4 4 1 0 4 4 4 0 Protein of unknown function (DUF4014) STT3 PF02516.9 EPA05224.1 - 0.076 11.9 26.4 0.061 12.2 17.6 1.4 1 1 0 1 1 1 0 Oligosaccharyl transferase STT3 subunit Sec20 PF03908.8 EPA05224.1 - 1.8 8.3 4.1 16 5.2 1.3 2.8 2 0 0 2 2 2 0 Sec20 Methyltransf_14 PF08484.6 EPA05225.1 - 1.5e-60 203.3 0.1 2.5e-60 202.6 0.0 1.4 1 0 0 1 1 1 1 C-methyltransferase C-terminal domain Methyltransf_13 PF08421.6 EPA05225.1 - 4.7e-18 64.4 0.8 8.3e-18 63.6 0.5 1.4 1 0 0 1 1 1 1 Putative zinc binding domain Methyltransf_23 PF13489.1 EPA05225.1 - 2.9e-16 59.5 0.0 6.7e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA05225.1 - 4.2e-10 39.4 0.5 1.9e-09 37.3 0.1 2.0 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA05225.1 - 1.1e-08 35.4 0.0 3.3e-08 33.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA05225.1 - 1.8e-08 34.7 0.0 5e-08 33.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain MetW PF07021.7 EPA05225.1 - 0.055 12.8 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_21 PF05050.7 EPA05226.1 - 1.2e-19 70.8 0.6 1.7e-19 70.3 0.4 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain V_cholerae_RfbT PF05575.6 EPA05226.1 - 3e-08 33.0 2.3 3.7e-08 32.7 1.6 1.2 1 0 0 1 1 1 1 Vibrio cholerae RfbT protein Met_10 PF02475.11 EPA05226.1 - 3.9e-07 29.8 0.3 7.7e-07 28.8 0.1 1.5 1 1 0 1 1 1 1 Met-10+ like-protein Methyltransf_18 PF12847.2 EPA05226.1 - 2.9e-05 24.5 0.0 5.2e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_22 PF13383.1 EPA05226.1 - 0.0017 17.9 0.2 0.0022 17.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methylase_S PF01420.14 EPA05226.1 - 0.0048 16.8 0.7 0.0048 16.8 0.5 2.2 1 1 1 2 2 2 1 Type I restriction modification DNA specificity domain DUF2972 PF11186.3 EPA05226.1 - 0.024 14.5 7.6 0.054 13.3 5.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2972) FtsJ PF01728.14 EPA05226.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase Acetyltransf_3 PF13302.1 EPA05227.1 - 0.00039 20.5 0.0 0.00055 20.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EPA05227.1 - 0.0007 19.5 0.1 0.0053 16.6 0.1 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3650 PF12368.3 EPA05227.1 - 0.032 13.7 1.3 0.067 12.6 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3650) Methyltransf_11 PF08241.7 EPA05228.1 - 1.5e-15 57.4 0.0 2.9e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA05228.1 - 2.3e-13 50.0 0.1 4.1e-13 49.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EPA05228.1 - 4.6e-10 39.7 0.0 1.1e-09 38.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA05228.1 - 2.9e-08 33.5 0.0 4.8e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA05228.1 - 4.7e-07 30.1 0.0 9e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA05228.1 - 2.5e-06 28.0 0.0 4.4e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EPA05228.1 - 0.00011 22.1 0.0 0.00015 21.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EPA05228.1 - 0.001 18.2 0.0 0.0021 17.2 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.6 EPA05228.1 - 0.0028 16.4 0.0 0.0044 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MetW PF07021.7 EPA05228.1 - 0.01 15.2 0.0 0.021 14.2 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Zn_ribbon_recom PF13408.1 EPA05228.1 - 0.022 14.9 0.0 0.047 13.9 0.0 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Glucokinase PF02685.11 EPA05228.1 - 0.14 10.8 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 Glucokinase Gemini_AL3 PF01407.12 EPA05228.1 - 0.34 10.3 2.7 0.21 11.0 0.3 1.8 2 0 0 2 2 2 0 Geminivirus AL3 protein NeuB PF03102.9 EPA05229.1 - 2.8e-80 268.9 0.0 3.4e-80 268.6 0.0 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.7 EPA05229.1 - 0.008 16.5 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 SAF domain RmlD_sub_bind PF04321.12 EPA05230.1 - 5.9e-22 77.8 0.0 6.8e-22 77.6 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 EPA05230.1 - 8.8e-15 54.7 0.1 1e-14 54.5 0.1 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EPA05230.1 - 2.7e-10 39.4 1.7 5.8e-10 38.3 1.2 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 EPA05230.1 - 5e-09 35.4 2.0 2.6e-07 29.8 1.4 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 EPA05230.1 - 7.4e-07 28.3 0.3 4.2e-06 25.8 0.1 1.9 1 1 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.1 EPA05230.1 - 0.0011 18.9 0.0 0.0014 18.7 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding Semialdhyde_dh PF01118.19 EPA05230.1 - 0.0048 17.1 0.0 0.0054 17.0 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Phage_head_fibr PF11133.3 EPA05230.1 - 0.0098 15.1 0.8 0.015 14.4 0.6 1.3 1 1 0 1 1 1 1 Head fiber protein DapB_N PF01113.15 EPA05230.1 - 0.029 14.3 0.1 0.06 13.2 0.0 1.6 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.20 EPA05230.1 - 0.16 11.8 0.6 5.2 6.9 0.4 2.1 1 1 0 1 1 1 0 short chain dehydrogenase NTP_transferase PF00483.18 EPA05231.1 - 6.6e-55 186.0 0.0 8.3e-55 185.7 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 EPA05231.1 - 1.5e-12 46.3 10.5 1.1e-06 27.8 0.5 3.3 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 EPA05231.1 - 5.3e-11 42.8 0.0 7.2e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.1 EPA05231.1 - 3.5e-06 26.4 7.4 3.7e-05 23.1 3.7 2.8 1 1 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase DegT_DnrJ_EryC1 PF01041.12 EPA05232.1 - 1.3e-69 235.0 0.0 1.6e-69 234.7 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Glyco_trans_4_4 PF13579.1 EPA05233.1 - 0.00044 20.4 0.0 0.0024 18.0 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Epimerase_2 PF02350.14 EPA05233.1 - 0.0014 17.4 0.0 0.0018 17.1 0.0 1.2 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase Glyco_trans_4_2 PF13477.1 EPA05233.1 - 0.052 13.3 0.2 0.43 10.4 0.2 2.1 1 1 0 1 1 1 0 Glycosyl transferase 4-like Glyco_trans_1_3 PF13528.1 EPA05233.1 - 0.075 12.2 0.0 0.083 12.0 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 1 Glyco_transf_4 PF13439.1 EPA05233.1 - 0.11 12.2 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase Family 4 CTK3 PF12243.3 EPA05233.1 - 0.11 12.1 0.1 0.13 11.9 0.1 1.3 1 1 0 1 1 1 0 CTD kinase subunit gamma CTK3 Methyltransf_23 PF13489.1 EPA05234.1 - 4.7e-20 71.9 0.0 6.9e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA05234.1 - 1.6e-13 51.2 0.0 2.8e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA05234.1 - 1.6e-12 47.7 0.0 2.5e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA05234.1 - 7.9e-11 42.3 0.0 1.4e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA05234.1 - 5.4e-09 35.8 0.0 7.9e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.7 EPA05234.1 - 2.8e-05 23.5 0.0 3.9e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.1 EPA05234.1 - 0.00015 22.0 0.0 0.00074 19.8 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EPA05234.1 - 0.00042 20.3 0.0 0.0012 18.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 EPA05234.1 - 0.00083 18.5 0.0 0.0012 18.0 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB MetW PF07021.7 EPA05234.1 - 0.0034 16.7 0.0 0.018 14.4 0.0 1.9 1 1 1 2 2 2 1 Methionine biosynthesis protein MetW TPMT PF05724.6 EPA05234.1 - 0.065 12.6 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Formyl_trans_N PF00551.14 EPA05235.1 - 3.4e-11 43.0 0.0 4.1e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase LAGLIDADG_3 PF14528.1 EPA05236.1 - 0.014 15.6 1.9 0.031 14.5 1.4 1.6 2 0 0 2 2 2 0 LAGLIDADG-like domain KMP11 PF03037.11 EPA05236.1 - 0.065 13.8 4.9 0.18 12.4 3.1 2.0 2 1 0 2 2 2 0 Kinetoplastid membrane protein 11 Alg14 PF08660.6 EPA05236.1 - 0.098 12.6 0.4 0.13 12.2 0.2 1.1 1 0 0 1 1 1 0 Oligosaccharide biosynthesis protein Alg14 like NTP_transferase PF00483.18 EPA05237.1 - 2.3e-18 66.4 0.0 5.6e-18 65.1 0.0 1.6 1 1 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 EPA05237.1 - 5e-09 36.4 0.0 5.4e-09 36.3 0.0 1.5 1 1 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.14 EPA05237.1 - 0.027 13.9 0.0 0.044 13.2 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Hexapep PF00132.19 EPA05239.1 - 3e-09 35.9 15.9 1.7e-05 24.1 3.4 3.8 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EPA05239.1 - 1.4e-06 27.7 11.5 0.034 13.7 0.0 4.4 3 2 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase TylF PF05711.6 EPA05240.1 - 1.9e-20 73.0 0.0 2.5e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.1 EPA05240.1 - 6.9e-11 42.9 0.0 1e-10 42.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Polysacc_synt_2 PF02719.10 EPA05241.1 - 3.3e-96 321.6 0.3 3.9e-96 321.4 0.2 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.16 EPA05241.1 - 1.8e-28 99.6 0.1 3.4e-27 95.3 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EPA05241.1 - 1.8e-22 79.4 0.2 1.2e-21 76.6 0.1 1.9 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EPA05241.1 - 3.1e-17 62.4 0.0 4.1e-15 55.4 0.0 2.4 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 EPA05241.1 - 2.5e-11 42.9 2.3 6.1e-09 35.1 1.1 2.9 1 1 1 2 2 2 2 Male sterility protein adh_short PF00106.20 EPA05241.1 - 5.9e-10 39.3 0.0 9e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 EPA05241.1 - 1.9e-09 37.8 0.0 2.5e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EPA05241.1 - 9.4e-08 31.5 0.0 1.2e-07 31.2 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family KR PF08659.5 EPA05241.1 - 0.0001 22.0 0.0 0.00015 21.4 0.0 1.3 1 0 0 1 1 1 1 KR domain Saccharop_dh PF03435.13 EPA05241.1 - 0.00053 19.0 0.1 0.0049 15.8 0.0 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase F420_oxidored PF03807.12 EPA05241.1 - 0.0076 16.6 0.0 0.03 14.7 0.0 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.19 EPA05241.1 - 0.014 15.6 0.0 0.09 13.0 0.0 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.13 EPA05241.1 - 0.028 14.4 0.1 0.065 13.2 0.0 1.7 1 1 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.15 EPA05241.1 - 0.063 13.3 0.2 0.19 11.8 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DUF2526 PF10735.4 EPA05242.1 - 0.08 12.9 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2526) RmlD_sub_bind PF04321.12 EPA05243.1 - 8.3e-12 44.5 0.0 9.4e-12 44.4 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain DUF3042 PF11240.3 EPA05243.1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) Epimerase PF01370.16 EPA05244.1 - 1.2e-56 191.8 0.0 1.5e-56 191.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EPA05244.1 - 3.9e-19 68.4 0.0 5.2e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EPA05244.1 - 1.1e-17 63.9 0.0 1.3e-17 63.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 EPA05244.1 - 5.3e-14 51.8 0.0 4e-13 48.9 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 EPA05244.1 - 9.5e-14 50.9 0.2 5.9e-13 48.3 0.1 1.9 1 1 0 1 1 1 1 Male sterility protein Epimerase_Csub PF13950.1 EPA05244.1 - 0.032 14.1 0.0 0.064 13.2 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose 4-epimerase C-term subunit Epimerase PF01370.16 EPA05245.1 - 2e-37 128.8 0.0 2.4e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EPA05245.1 - 6.8e-11 41.5 0.0 9.2e-11 41.1 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 EPA05245.1 - 1.7e-05 23.8 0.0 2.2e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.10 EPA05245.1 - 0.0021 17.0 0.0 0.013 14.3 0.0 2.1 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein FdtA PF05523.6 EPA05246.1 - 1.4e-20 73.0 0.3 1.7e-20 72.8 0.2 1.0 1 0 0 1 1 1 1 WxcM-like, C-terminal Cupin_2 PF07883.6 EPA05246.1 - 2.7e-05 23.5 0.1 0.00025 20.4 0.1 2.1 1 1 0 1 1 1 1 Cupin domain Cupin_1 PF00190.17 EPA05246.1 - 0.0043 16.4 0.0 0.0055 16.1 0.0 1.2 1 0 0 1 1 1 1 Cupin dTDP_sugar_isom PF00908.12 EPA05246.1 - 0.042 13.1 0.0 0.059 12.6 0.0 1.3 1 0 0 1 1 1 0 dTDP-4-dehydrorhamnose 3,5-epimerase ARD PF03079.9 EPA05246.1 - 0.07 13.0 0.1 0.086 12.7 0.1 1.3 1 0 0 1 1 1 0 ARD/ARD' family MannoseP_isomer PF01050.13 EPA05246.1 - 0.094 12.3 0.4 0.11 12.1 0.3 1.2 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase dTDP_sugar_isom PF00908.12 EPA05247.1 - 1.1e-61 207.2 0.0 1.2e-61 207.0 0.0 1.0 1 0 0 1 1 1 1 dTDP-4-dehydrorhamnose 3,5-epimerase FdtA PF05523.6 EPA05247.1 - 4e-05 23.1 0.0 6.9e-05 22.3 0.0 1.4 1 1 0 1 1 1 1 WxcM-like, C-terminal DUF3473 PF11959.3 EPA05249.1 - 3.6e-30 104.1 0.2 6.6e-30 103.2 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3473) Polysacc_deac_1 PF01522.16 EPA05249.1 - 8.6e-23 80.3 0.0 1.3e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyoxalase_4 PF13669.1 EPA05250.1 - 1.3e-16 60.5 0.0 1.6e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 EPA05250.1 - 0.00014 22.3 0.0 0.00014 22.3 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 EPA05250.1 - 0.0058 16.6 0.0 0.0084 16.0 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.1 EPA05250.1 - 0.068 13.0 0.0 0.13 12.1 0.0 1.5 2 0 0 2 2 2 0 Glyoxalase-like domain ACPS PF01648.15 EPA05251.1 - 2.3e-15 56.3 0.3 2.7e-15 56.1 0.2 1.1 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Glyphos_transf PF04464.9 EPA05252.1 - 8e-06 24.8 5.6 6.8e-05 21.7 3.9 2.1 1 1 0 1 1 1 1 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase Epimerase_2 PF02350.14 EPA05252.1 - 0.00036 19.3 0.1 0.00071 18.4 0.1 1.5 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase Glycos_transf_1 PF00534.15 EPA05253.1 - 2.3e-22 79.2 0.0 3.3e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EPA05253.1 - 8.1e-14 51.9 0.0 9.6e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EPA05253.1 - 1.7e-11 44.1 0.0 2.4e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Guanylate_cyc PF00211.15 EPA05255.1 - 6.5e-18 64.7 0.1 8.6e-18 64.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Aldo_ket_red PF00248.16 EPA05256.1 - 5.4e-32 110.7 0.0 1.9e-31 108.9 0.0 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family DUF321 PF03778.8 EPA05256.1 - 0.24 10.8 3.2 0.18 11.2 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF321) RNA_pol_Rpb6 PF01192.17 EPA05258.1 - 1.3e-12 47.2 0.1 1.3e-12 47.2 0.1 2.5 3 0 0 3 3 3 1 RNA polymerase Rpb6 DUF3782 PF12644.2 EPA05258.1 - 0.44 10.3 3.4 0.48 10.2 1.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3782) DS PF01916.12 EPA05259.1 - 3.8e-57 193.7 0.1 4.4e-57 193.4 0.1 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Asn_synthase PF00733.16 EPA05260.1 - 2.6e-35 122.1 0.0 7.2e-34 117.4 0.0 2.0 1 1 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.12 EPA05260.1 - 5.9e-06 25.3 0.1 1.3e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 NAD synthase QueC PF06508.8 EPA05260.1 - 6.6e-05 22.2 2.0 9.2e-05 21.8 0.1 2.2 2 1 0 2 2 2 1 Queuosine biosynthesis protein QueC ATP_bind_3 PF01171.15 EPA05260.1 - 0.0001 21.8 0.0 0.0002 20.8 0.0 1.6 1 0 0 1 1 1 1 PP-loop family ThiI PF02568.9 EPA05260.1 - 0.00027 20.4 0.0 0.0006 19.3 0.0 1.5 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) zf-ribbon_3 PF13248.1 EPA05260.1 - 0.0017 17.5 1.4 0.0017 17.5 1.0 1.9 2 0 0 2 2 2 1 zinc-ribbon domain tRNA_Me_trans PF03054.11 EPA05260.1 - 0.0028 16.2 0.0 0.0067 15.0 0.0 1.7 2 0 0 2 2 2 1 tRNA methyl transferase DZR PF12773.2 EPA05260.1 - 0.14 12.0 3.3 0.31 10.9 0.6 2.3 2 0 0 2 2 2 0 Double zinc ribbon zinc_ribbon_2 PF13240.1 EPA05260.1 - 0.72 9.4 4.9 17 5.0 3.7 2.5 1 1 1 2 2 2 0 zinc-ribbon domain RecR PF02132.10 EPA05260.1 - 6.9 6.1 8.4 0.31 10.5 1.3 2.2 2 1 0 2 2 2 0 RecR protein Xol-1_N PF09108.5 EPA05261.1 - 0.038 13.6 0.0 0.047 13.3 0.0 1.2 1 0 0 1 1 1 0 Switch protein XOL-1, N-terminal Alba PF01918.16 EPA05262.1 - 3.7e-09 36.0 0.2 5.2e-09 35.5 0.1 1.3 1 0 0 1 1 1 1 Alba Ribosomal_L2 PF00181.18 EPA05262.1 - 0.031 14.2 0.2 0.065 13.2 0.0 1.6 2 0 0 2 2 2 0 Ribosomal Proteins L2, RNA binding domain Rpp20 PF12328.3 EPA05262.1 - 0.13 11.8 0.1 0.15 11.7 0.1 1.4 1 1 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P THAP PF05485.7 EPA05263.1 - 0.15 12.2 1.1 1.5 9.0 0.8 2.0 1 1 0 1 1 1 0 THAP domain Cyclophil_like PF04126.8 EPA05265.1 - 2.3e-09 36.9 0.0 3.6e-09 36.2 0.0 1.3 1 1 0 1 1 1 1 Cyclophilin-like DUF3830 PF12903.2 EPA05265.1 - 0.00081 18.7 0.0 0.0099 15.2 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3830) Ribosomal_S25 PF03297.10 EPA05268.1 - 1.3e-06 28.3 3.1 1.6e-06 28.0 2.2 1.0 1 0 0 1 1 1 1 S25 ribosomal protein TrmB PF01978.14 EPA05268.1 - 0.0063 16.1 0.1 0.0085 15.7 0.1 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB DUF977 PF06163.6 EPA05268.1 - 0.013 15.2 0.1 0.016 14.9 0.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) DDRGK PF09756.4 EPA05268.1 - 0.021 14.2 1.5 0.042 13.2 1.0 1.5 1 1 0 1 1 1 0 DDRGK domain MarR_2 PF12802.2 EPA05268.1 - 0.039 13.6 0.0 0.048 13.3 0.0 1.2 1 0 0 1 1 1 0 MarR family HTH_10 PF04967.7 EPA05268.1 - 0.11 12.0 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain UbiA PF01040.13 EPA05269.1 - 2.2e-27 95.9 21.9 2.9e-27 95.5 15.2 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF3488 PF11992.3 EPA05269.1 - 0.02 13.5 0.8 0.031 12.9 0.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3488) Phage_holin_2 PF04550.7 EPA05269.1 - 0.044 13.8 0.2 0.044 13.8 0.2 3.2 4 0 0 4 4 4 0 Phage holin family 2 Rhabdo_glycop PF00974.13 EPA05270.1 - 0.054 11.7 0.1 0.1 10.8 0.0 1.3 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein Spore_YhaL PF14147.1 EPA05270.1 - 0.17 11.3 1.0 0.37 10.2 0.7 1.6 1 0 0 1 1 1 0 Sporulation protein YhaL NPCBM_assoc PF10633.4 EPA05272.1 - 0.0024 17.8 0.6 0.048 13.7 0.5 2.5 2 0 0 2 2 2 1 NPCBM-associated, NEW3 domain of alpha-galactosidase CARDB PF07705.6 EPA05272.1 - 0.0026 17.8 0.8 0.29 11.2 0.1 2.8 2 1 0 2 2 2 2 CARDB RskA PF10099.4 EPA05272.1 - 0.05 13.3 0.0 0.078 12.7 0.0 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA YHS PF04945.8 EPA05273.1 - 4.3e-10 39.2 0.1 5.5e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 YHS domain ATPase-cat_bd PF12156.3 EPA05273.1 - 1.4e-05 25.5 0.6 1.7e-05 25.2 0.4 1.1 1 0 0 1 1 1 1 Putative metal-binding domain of cation transport ATPase Ta0938 PF11494.3 EPA05273.1 - 0.0031 17.5 0.1 0.0031 17.5 0.1 1.1 1 0 0 1 1 1 1 Ta0938 Arc_trans_TRASH PF08394.5 EPA05273.1 - 0.01 16.0 0.9 0.014 15.4 0.6 1.3 1 0 0 1 1 1 0 Archaeal TRASH domain zf-BED PF02892.10 EPA05273.1 - 0.072 12.8 1.3 0.088 12.5 0.9 1.2 1 0 0 1 1 1 0 BED zinc finger Prok-JAB PF14464.1 EPA05274.1 - 7.8e-12 44.6 0.0 8.9e-12 44.5 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain JAB PF01398.16 EPA05274.1 - 0.056 13.1 0.0 0.42 10.3 0.0 1.9 1 1 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease HTH_19 PF12844.2 EPA05275.1 - 3.9e-05 23.6 0.1 0.00058 19.8 0.0 2.2 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.17 EPA05275.1 - 6.1e-05 22.7 0.0 0.00014 21.5 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix HTH_23 PF13384.1 EPA05275.1 - 0.012 15.2 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain HTH_26 PF13443.1 EPA05275.1 - 0.034 14.3 0.2 0.19 11.9 0.0 2.3 2 1 1 3 3 3 0 Cro/C1-type HTH DNA-binding domain HTH_11 PF08279.7 EPA05275.1 - 0.052 13.1 0.6 0.1 12.2 0.0 1.7 2 0 0 2 2 2 0 HTH domain HTH_37 PF13744.1 EPA05275.1 - 0.071 12.9 0.1 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain CAS_CSE1 PF03378.10 EPA05275.1 - 0.093 11.0 0.0 0.13 10.5 0.0 1.3 1 1 0 1 1 1 0 CAS/CSE protein, C-terminus DUF1628 PF07790.6 EPA05276.1 - 0.015 16.0 3.8 0.015 16.0 2.7 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1628) DUF3899 PF13038.1 EPA05276.1 - 0.094 12.8 0.2 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) CbiD PF01888.12 EPA05278.1 - 1.9e-73 246.6 0.8 2.2e-73 246.4 0.6 1.0 1 0 0 1 1 1 1 CbiD DUF3042 PF11240.3 EPA05278.1 - 0.034 13.9 0.9 0.12 12.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) DUF1049 PF06305.6 EPA05279.1 - 0.00054 19.3 0.0 0.00096 18.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1049) DUF778 PF05608.7 EPA05279.1 - 0.093 12.6 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF778) adh_short PF00106.20 EPA05280.1 - 6.2e-29 101.0 0.0 9.2e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EPA05280.1 - 5e-22 78.8 0.0 5.8e-22 78.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EPA05280.1 - 1.4e-08 34.6 0.0 1.2e-07 31.6 0.0 2.0 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EPA05280.1 - 1.2e-07 31.4 0.0 2.1e-07 30.6 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.14 EPA05280.1 - 0.051 12.6 0.0 0.087 11.8 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain AnfO_nitrog PF09582.5 EPA05280.1 - 0.12 11.5 0.3 0.19 10.8 0.1 1.4 2 0 0 2 2 2 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) NAD_binding_10 PF13460.1 EPA05281.1 - 2.8e-14 53.5 0.0 3.7e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EPA05281.1 - 1.7e-09 37.4 0.0 3.7e-08 33.1 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 EPA05281.1 - 4.2e-09 35.9 1.6 1.6e-08 34.1 1.1 1.7 1 1 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.14 EPA05281.1 - 7e-07 28.2 0.1 0.0002 20.1 0.3 2.3 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EPA05281.1 - 2.9e-06 26.4 0.3 0.0021 17.0 0.2 2.8 2 1 0 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.12 EPA05281.1 - 7.9e-05 21.6 0.0 0.023 13.5 0.0 2.3 2 1 0 2 2 2 2 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 EPA05281.1 - 0.041 12.7 0.1 0.65 8.8 0.1 2.2 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein AP_endonuc_2 PF01261.19 EPA05281.1 - 0.063 12.5 0.0 0.087 12.0 0.0 1.2 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel S-AdoMet_synt_C PF02773.11 EPA05282.1 - 2e-69 231.6 0.3 2.9e-69 231.1 0.0 1.4 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 EPA05282.1 - 7.5e-36 122.7 0.5 1.3e-35 121.9 0.3 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain adh_short_C2 PF13561.1 EPA05283.1 - 2.1e-29 102.9 0.1 2.6e-29 102.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EPA05283.1 - 3.1e-19 69.4 0.2 2.7e-17 63.1 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.5 EPA05283.1 - 0.018 14.7 0.0 0.035 13.7 0.0 1.4 1 1 0 1 1 1 0 KR domain NAD_binding_3 PF03447.11 EPA05283.1 - 0.034 14.5 0.2 0.13 12.7 0.0 2.0 2 1 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain Epimerase PF01370.16 EPA05283.1 - 0.034 13.5 0.2 0.069 12.5 0.2 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EPA05283.1 - 0.04 12.8 0.0 0.058 12.2 0.0 1.3 1 1 0 1 1 1 0 RmlD substrate binding domain Glycos_transf_2 PF00535.21 EPA05284.1 - 2.1e-21 76.3 1.6 3.8e-21 75.5 1.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 EPA05284.1 - 3.6e-08 32.8 8.2 1.9e-07 30.4 5.7 2.2 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.1 EPA05284.1 - 4.4e-07 29.9 0.0 6.3e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 PRD PF00874.15 EPA05285.1 - 0.15 12.1 1.7 1.6 8.9 0.1 2.1 1 1 1 2 2 2 0 PRD domain Epimerase PF01370.16 EPA05286.1 - 5.8e-12 45.5 0.0 7.1e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EPA05286.1 - 1.5e-09 36.9 0.0 2.2e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 EPA05286.1 - 4.8e-07 28.9 0.2 0.00086 18.2 0.0 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 EPA05286.1 - 1.6e-05 23.9 0.0 6e-05 22.0 0.0 1.7 1 1 0 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.12 EPA05286.1 - 0.0011 17.8 0.0 0.004 16.0 0.0 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain Semialdhyde_dh PF01118.19 EPA05286.1 - 0.027 14.7 0.0 0.07 13.4 0.0 1.7 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain FAD_binding_3 PF01494.14 EPA05286.1 - 0.029 13.4 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.1 EPA05286.1 - 0.036 14.0 0.0 0.095 12.7 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EPA05286.1 - 0.061 13.7 0.0 0.18 12.2 0.0 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EPA05286.1 - 0.063 12.1 0.0 0.089 11.6 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EPA05286.1 - 0.087 12.6 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SIS_2 PF13580.1 EPA05287.1 - 5.9e-28 97.2 1.0 8.4e-28 96.8 0.7 1.2 1 0 0 1 1 1 1 SIS domain SIS PF01380.17 EPA05287.1 - 1.3e-05 24.8 0.6 0.0003 20.3 0.0 2.6 1 1 0 2 2 2 1 SIS domain DUF2450 PF10475.4 EPA05287.1 - 0.024 13.5 1.2 0.039 12.8 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) Epimerase PF01370.16 EPA05288.1 - 0.0024 17.3 0.0 0.0045 16.4 0.0 1.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Hydrolase_3 PF08282.7 EPA05290.1 - 6.8e-12 45.5 0.0 8e-12 45.2 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EPA05290.1 - 0.0042 17.5 0.0 0.0055 17.1 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EPA05290.1 - 0.044 14.0 0.0 0.066 13.4 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Gamma-thionin PF00304.15 EPA05290.1 - 0.054 13.5 4.2 0.83 9.7 0.4 2.1 2 0 0 2 2 2 0 Gamma-thionin family Toxin_3 PF00537.13 EPA05290.1 - 0.22 11.4 5.6 3.9 7.4 0.5 2.2 2 0 0 2 2 2 0 Scorpion toxin-like domain TrmB PF01978.14 EPA05291.1 - 4.6e-21 74.2 0.1 1.7e-20 72.4 0.0 2.0 2 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.3 EPA05291.1 - 2.3e-07 30.0 0.0 2.8e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB HTH_IclR PF09339.5 EPA05291.1 - 6.6e-05 22.4 0.0 0.00031 20.2 0.0 2.1 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR PF01047.17 EPA05291.1 - 0.00024 20.7 0.0 0.001 18.7 0.0 2.0 1 1 1 2 2 2 1 MarR family HTH_24 PF13412.1 EPA05291.1 - 0.0023 17.2 0.0 0.0057 16.0 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_27 PF13463.1 EPA05291.1 - 0.0037 17.5 0.0 0.012 15.9 0.0 1.9 1 0 0 1 1 1 1 Winged helix DNA-binding domain Penicillinase_R PF03965.11 EPA05291.1 - 0.0052 16.8 0.0 0.038 14.0 0.0 2.1 2 0 0 2 2 2 1 Penicillinase repressor Rrf2 PF02082.15 EPA05291.1 - 0.047 13.8 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 Transcriptional regulator YflT PF11181.3 EPA05291.1 - 0.056 13.6 0.2 2.9 8.0 0.0 2.9 2 1 0 3 3 3 0 Heat induced stress protein YflT PLDc_2 PF13091.1 EPA05291.1 - 0.083 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 PLD-like domain MarR_2 PF12802.2 EPA05291.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_9 PF08221.6 EPA05291.1 - 0.14 12.0 0.0 0.43 10.4 0.0 1.8 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain DUF2207 PF09972.4 EPA05292.1 - 0.056 12.0 1.0 0.059 11.9 0.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF805 PF05656.9 EPA05292.1 - 0.095 12.5 1.9 0.13 12.0 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF805) DUF1494 PF07379.6 EPA05292.1 - 0.34 10.7 2.3 3.7 7.4 0.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1494) AP_endonuc_2 PF01261.19 EPA05293.1 - 3.2e-15 56.0 0.0 4.1e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF1463 PF07316.6 EPA05293.1 - 0.0055 16.2 0.5 0.0096 15.5 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1463) Hydrolase_like PF13242.1 EPA05294.1 - 3e-11 42.8 0.0 4.7e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like PNK3P PF08645.6 EPA05294.1 - 7.8e-11 41.6 1.0 9.6e-11 41.3 0.7 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase HAD_2 PF13419.1 EPA05294.1 - 8.6e-08 32.5 0.0 3.6e-06 27.3 0.0 2.1 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EPA05294.1 - 5.5e-05 23.6 0.0 6.5e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.9 EPA05294.1 - 0.00053 19.4 0.2 0.00079 18.8 0.1 1.2 1 0 0 1 1 1 1 HAD superfamily, subfamily IIIB (Acid phosphatase) HAD PF12710.2 EPA05294.1 - 0.0071 16.5 0.2 0.0093 16.1 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 EPA05294.1 - 0.011 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase AP_endonuc_2 PF01261.19 EPA05295.1 - 1.4e-11 44.0 0.0 2.1e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF273 PF03314.9 EPA05295.1 - 0.02 14.2 0.2 0.031 13.5 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function, DUF273 Epimerase PF01370.16 EPA05296.1 - 8.4e-25 87.5 0.0 9.2e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EPA05296.1 - 9.9e-16 57.4 0.0 1.1e-15 57.2 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 EPA05296.1 - 1.3e-15 56.8 0.0 1.6e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 EPA05296.1 - 3.7e-13 49.0 0.0 3.4e-12 45.8 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 EPA05296.1 - 1.4e-06 27.4 0.2 6.3e-05 22.0 0.1 2.4 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 EPA05296.1 - 1.5e-06 28.3 0.0 1.6e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EPA05296.1 - 0.00021 20.5 0.0 0.00029 20.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.20 EPA05296.1 - 0.00027 20.8 0.0 0.00035 20.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase TrkA_N PF02254.13 EPA05296.1 - 0.00087 19.2 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain Saccharop_dh PF03435.13 EPA05296.1 - 0.0019 17.2 0.0 0.0028 16.7 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase KR PF08659.5 EPA05296.1 - 0.054 13.1 0.0 0.09 12.4 0.0 1.3 1 1 0 1 1 1 0 KR domain Pyr_redox PF00070.22 EPA05296.1 - 0.069 13.5 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EPA05296.1 - 0.095 12.7 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Polysacc_synt_3 PF13440.1 EPA05298.1 - 1.9e-10 40.6 22.9 6e-07 29.1 12.8 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.1 EPA05298.1 - 5.9e-07 29.3 1.4 5.9e-07 29.3 1.0 4.3 4 0 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Polysacc_synt PF01943.12 EPA05298.1 - 6e-05 22.4 10.5 6e-05 22.4 7.3 3.6 2 1 2 4 4 4 2 Polysaccharide biosynthesis protein TMEM37 PF15108.1 EPA05298.1 - 0.017 14.8 1.2 0.058 13.0 0.8 2.0 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family PIRT PF15099.1 EPA05298.1 - 0.55 9.4 4.6 0.82 8.8 0.9 2.4 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family DUF3938 PF13074.1 EPA05298.1 - 0.9 9.4 10.0 0.08 12.7 1.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3938) DUF4407 PF14362.1 EPA05298.1 - 2.1 7.2 8.4 0.42 9.5 1.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) adh_short_C2 PF13561.1 EPA05299.1 - 3.1e-19 69.6 0.0 3.9e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase RmlD_sub_bind PF04321.12 EPA05299.1 - 5.1e-08 32.1 0.0 2.2e-07 30.0 0.0 1.8 1 1 1 2 2 2 1 RmlD substrate binding domain adh_short PF00106.20 EPA05299.1 - 1.1e-06 28.6 0.0 3.2e-05 23.8 0.0 2.4 2 1 0 2 2 2 1 short chain dehydrogenase Epimerase PF01370.16 EPA05299.1 - 1.4e-05 24.6 0.0 3.8e-05 23.2 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.15 EPA05299.1 - 0.083 12.8 0.0 0.29 11.0 0.0 2.2 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus DUF3473 PF11959.3 EPA05300.1 - 2.1e-25 88.6 0.0 3.5e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3473) Polysacc_deac_1 PF01522.16 EPA05300.1 - 8.5e-15 54.4 0.0 1.2e-13 50.7 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide deacetylase Asn_synthase PF00733.16 EPA05301.1 - 8.9e-21 74.5 0.0 1.1e-20 74.2 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase DUF3272 PF11676.3 EPA05301.1 - 0.45 10.5 2.8 13 5.8 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3272) GFO_IDH_MocA PF01408.17 EPA05302.1 - 1.2e-23 83.9 0.0 1.7e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NeuB PF03102.9 EPA05303.1 - 1.2e-51 175.2 0.0 1.4e-51 174.9 0.0 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.7 EPA05303.1 - 0.078 13.3 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 SAF domain DUF733 PF05306.6 EPA05303.1 - 0.088 13.1 0.6 0.65 10.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF733) CTP_transf_3 PF02348.14 EPA05304.1 - 1.1e-07 31.7 0.0 1.1e-07 31.6 0.0 1.0 1 0 0 1 1 1 1 Cytidylyltransferase NeuB PF03102.9 EPA05305.1 - 2.1e-70 236.6 0.2 2.4e-70 236.4 0.1 1.0 1 0 0 1 1 1 1 NeuB family Fe_dep_repress PF01325.14 EPA05306.1 - 9.1e-12 44.7 0.1 1.3e-11 44.2 0.1 1.2 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain MarR PF01047.17 EPA05306.1 - 0.0077 15.9 0.0 0.0094 15.6 0.0 1.1 1 0 0 1 1 1 1 MarR family NLPC_P60 PF00877.14 EPA05306.1 - 0.021 14.6 0.0 0.023 14.5 0.0 1.1 1 0 0 1 1 1 0 NlpC/P60 family ANT PF03374.9 EPA05306.1 - 0.03 14.3 0.0 0.031 14.3 0.0 1.2 1 0 0 1 1 1 0 Phage antirepressor protein KilAC domain MarR_2 PF12802.2 EPA05306.1 - 0.034 13.8 0.0 0.041 13.5 0.0 1.1 1 0 0 1 1 1 0 MarR family HTH_27 PF13463.1 EPA05306.1 - 0.039 14.2 0.0 0.053 13.8 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain TFIIE_beta PF02186.10 EPA05306.1 - 0.086 12.8 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 TFIIE beta subunit core domain HTH_37 PF13744.1 EPA05306.1 - 0.1 12.3 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain IF2_N PF04760.10 EPA05306.1 - 0.13 11.9 0.1 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region B12-binding PF02310.14 EPA05307.1 - 2e-16 59.9 0.0 4e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 B12 binding domain Radical_SAM PF04055.16 EPA05307.1 - 1.1e-15 58.2 0.0 2.5e-14 53.7 0.0 2.4 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.1 EPA05307.1 - 0.0081 16.2 5.0 5.7 7.0 2.4 3.3 2 1 0 2 2 2 2 4Fe-4S single cluster domain Glycos_transf_2 PF00535.21 EPA05308.1 - 8.2e-25 87.4 0.2 1.4e-24 86.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 EPA05308.1 - 1.4e-18 67.5 0.0 1.8e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 EPA05308.1 - 1.1e-06 28.0 3.5 8.4e-06 25.0 2.4 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EPA05308.1 - 0.0095 15.2 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.1 EPA05308.1 - 0.016 15.4 0.0 0.05 13.9 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferase family 2 Glyco_tranf_2_5 PF13712.1 EPA05308.1 - 0.017 14.4 0.3 13 4.9 0.0 3.1 2 1 1 3 3 3 0 Glycosyltransferase like family Glyco_trans_2_3 PF13632.1 EPA05308.1 - 0.031 13.9 0.0 0.049 13.3 0.0 1.4 1 1 0 1 1 1 0 Glycosyl transferase family group 2 Phage_endo_I PF05367.6 EPA05309.1 - 0.00093 18.6 0.4 0.0011 18.4 0.3 1.1 1 0 0 1 1 1 1 Phage endonuclease I Luteo_Vpg PF01659.11 EPA05309.1 - 0.015 14.9 0.2 0.016 14.9 0.1 1.0 1 0 0 1 1 1 0 Luteovirus putative VPg genome linked protein Glycos_transf_1 PF00534.15 EPA05310.1 - 7.1e-36 123.2 1.5 1.5e-35 122.1 1.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EPA05310.1 - 1.3e-16 60.9 0.0 2e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EPA05310.1 - 0.00023 21.3 0.0 0.0013 18.9 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 EPA05310.1 - 0.065 12.9 0.1 0.18 11.5 0.0 1.7 1 1 0 1 1 1 0 Glycosyltransferase Family 4 Fib_alpha PF08702.5 EPA05310.1 - 0.089 12.9 2.6 25 4.9 0.1 3.1 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family TylF PF05711.6 EPA05311.1 - 1.7e-16 60.0 0.1 2.1e-16 59.7 0.1 1.1 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.1 EPA05311.1 - 2.1e-13 51.0 0.0 2.8e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.7 EPA05311.1 - 0.00017 20.9 0.0 0.00074 18.8 0.0 1.9 1 1 0 2 2 2 1 Cephalosporin hydroxylase Methyltransf_18 PF12847.2 EPA05311.1 - 0.0097 16.4 0.0 0.018 15.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.12 EPA05311.1 - 0.02 13.9 0.4 0.39 9.7 0.4 2.1 2 0 0 2 2 2 0 O-methyltransferase Epimerase_2 PF02350.14 EPA05312.1 - 2.2e-07 30.0 0.1 3.7e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase Glyphos_transf PF04464.9 EPA05312.1 - 2e-06 26.8 4.0 2.8e-05 23.0 2.7 2.4 1 1 0 1 1 1 1 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase Capsule_synth PF05159.9 EPA05312.1 - 2.1e-05 24.1 0.1 3.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Capsule polysaccharide biosynthesis protein tRNA_NucTransf2 PF09249.6 EPA05312.1 - 0.01 15.7 0.0 0.034 14.0 0.0 1.9 1 0 0 1 1 1 1 tRNA nucleotidyltransferase, second domain Cas_CXXC_CXXC PF09706.5 EPA05312.1 - 0.28 11.3 2.3 24 5.1 0.0 3.1 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_CXXC_CXXC) Radical_SAM PF04055.16 EPA05313.1 - 5.3e-15 55.9 0.2 5.3e-15 55.9 0.1 2.7 3 0 0 3 3 3 1 Radical SAM superfamily Fer4_14 PF13394.1 EPA05313.1 - 1.1e-07 31.8 0.0 1.1e-07 31.8 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 EPA05313.1 - 1.3e-07 31.8 0.0 4.6e-07 30.0 0.0 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain Methyltransf_21 PF05050.7 EPA05314.1 - 5e-19 68.8 0.2 8.5e-19 68.1 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain Met_10 PF02475.11 EPA05314.1 - 3e-05 23.7 0.1 4e-05 23.2 0.1 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_18 PF12847.2 EPA05314.1 - 5.5e-05 23.7 0.0 7.1e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EPA05314.1 - 0.00019 21.0 0.0 0.00024 20.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.8 EPA05314.1 - 0.013 14.5 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.1 EPA05314.1 - 0.049 13.2 0.6 0.066 12.8 0.4 1.4 1 0 0 1 1 1 0 Methyltransferase domain Baculo_PEP_N PF04512.7 EPA05314.1 - 0.07 13.1 0.5 0.3 11.0 0.0 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, N terminus GMP_synt_C PF00958.17 EPA05315.1 - 1.4e-32 111.2 0.0 3.6e-32 109.9 0.0 1.7 2 0 0 2 2 2 1 GMP synthase C terminal domain NAD_synthase PF02540.12 EPA05315.1 - 0.00014 20.8 0.0 0.00028 19.8 0.0 1.4 1 0 0 1 1 1 1 NAD synthase PRANC PF09372.5 EPA05315.1 - 0.15 12.0 0.0 0.44 10.5 0.0 1.7 1 0 0 1 1 1 0 PRANC domain SPASM PF13186.1 EPA05316.1 - 2.3e-14 53.4 8.2 2.7e-14 53.2 2.9 3.1 3 0 0 3 3 3 1 Iron-sulfur cluster-binding domain Radical_SAM PF04055.16 EPA05316.1 - 5.3e-08 33.2 0.0 8.4e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Methyltransf_23 PF13489.1 EPA05317.1 - 9.8e-22 77.3 0.0 1.5e-21 76.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA05317.1 - 3.3e-13 49.4 0.1 6.8e-13 48.4 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA05317.1 - 3e-10 40.4 0.0 6.6e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA05317.1 - 2.2e-09 37.6 0.0 3.9e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 EPA05317.1 - 7.2e-08 32.0 0.2 1.2e-07 31.2 0.2 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.2 EPA05317.1 - 4.5e-06 27.2 0.0 7.8e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 EPA05317.1 - 6e-05 21.8 0.1 9.1e-05 21.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) DREV PF05219.7 EPA05317.1 - 0.0024 16.8 0.1 0.004 16.0 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase Sep15_SelM PF08806.6 EPA05317.1 - 0.0065 16.1 0.8 0.018 14.7 0.5 1.8 1 0 0 1 1 1 1 Sep15/SelM redox domain RrnaAD PF00398.15 EPA05317.1 - 0.021 13.8 0.0 0.036 13.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.1 EPA05317.1 - 0.022 15.1 0.0 0.04 14.2 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 EPA05317.1 - 0.033 13.5 0.1 0.075 12.4 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.1 EPA05317.1 - 0.039 13.6 0.0 0.065 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TarH PF02203.10 EPA05318.1 - 0.024 14.4 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Tar ligand binding domain homologue DUF4010 PF13194.1 EPA05318.1 - 0.072 12.3 0.4 0.092 12.0 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) Fig1 PF12351.3 EPA05318.1 - 0.076 12.9 2.0 0.1 12.4 1.4 1.2 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Neur_chan_memb PF02932.11 EPA05318.1 - 0.21 11.4 1.3 0.27 11.0 0.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TRP PF06011.7 EPA05318.1 - 0.68 8.4 6.3 1 7.8 4.3 1.3 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF3810 PF12725.2 EPA05318.1 - 1.4 7.7 4.4 2 7.2 3.0 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) Glyco_trans_1_4 PF13692.1 EPA05319.1 - 1.8e-15 57.3 0.0 2.7e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 EPA05319.1 - 5.8e-05 22.5 0.2 0.00019 20.8 0.0 2.0 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EPA05319.1 - 0.00021 21.4 0.0 0.0015 18.7 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.1 EPA05319.1 - 0.021 14.6 2.5 0.085 12.6 0.8 2.4 1 1 1 2 2 2 0 Glycosyl transferase 4-like Methyltransf_30 PF05430.6 EPA05319.1 - 0.12 12.0 0.0 0.39 10.3 0.0 1.8 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Binary_toxB PF03495.9 EPA05319.1 - 0.12 10.9 1.7 0.99 7.9 0.2 2.1 2 0 0 2 2 2 0 Clostridial binary toxin B/anthrax toxin PA DUF1947 PF09183.5 EPA05320.1 - 0.14 11.9 2.2 0.71 9.6 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1947) Hydrolase_6 PF13344.1 EPA05321.1 - 0.0022 17.8 0.2 0.0057 16.5 0.1 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EPA05321.1 - 0.011 16.1 0.2 0.03 14.7 0.1 1.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase GHMP_kinases_N PF00288.21 EPA05322.1 - 1e-11 44.7 0.4 2e-11 43.7 0.3 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EPA05322.1 - 2.2e-06 27.7 1.0 3.2e-06 27.2 0.0 1.8 2 0 0 2 2 2 1 GHMP kinases C terminal CAT_RBD PF03123.10 EPA05322.1 - 3.4 7.4 7.1 0.24 11.1 0.6 2.3 3 0 0 3 3 3 0 CAT RNA binding domain UDPG_MGDP_dh_N PF03721.9 EPA05323.1 - 3.6e-41 140.5 0.6 5.9e-41 139.8 0.1 1.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.10 EPA05323.1 - 7.4e-22 77.5 0.1 2.5e-21 75.7 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.14 EPA05323.1 - 3e-20 72.2 0.0 6.1e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_Gly3P_dh_N PF01210.18 EPA05323.1 - 9.6e-08 31.9 0.3 4.3e-05 23.2 0.0 2.6 2 0 0 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.14 EPA05323.1 - 7.5e-06 25.2 2.1 0.031 13.4 0.1 3.3 2 2 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 EPA05323.1 - 4.8e-05 23.0 0.0 8.4e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 EPA05323.1 - 0.0048 16.7 0.0 0.038 13.8 0.0 2.3 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Thi4 PF01946.12 EPA05323.1 - 0.0093 15.0 1.9 0.84 8.6 0.0 2.8 3 0 0 3 3 3 1 Thi4 family F420_oxidored PF03807.12 EPA05323.1 - 0.012 16.0 0.9 4 7.9 0.1 2.9 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.11 EPA05323.1 - 0.041 13.3 0.0 0.075 12.4 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.16 EPA05323.1 - 0.062 13.1 3.0 0.12 12.2 0.7 2.6 2 1 0 2 2 2 0 ThiF family NAD_binding_11 PF14833.1 EPA05323.1 - 0.07 13.1 0.1 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase dTDP_sugar_isom PF00908.12 EPA05324.1 - 1.9e-67 226.0 0.0 2.1e-67 225.8 0.0 1.0 1 0 0 1 1 1 1 dTDP-4-dehydrorhamnose 3,5-epimerase FdtA PF05523.6 EPA05324.1 - 0.031 13.7 0.1 0.049 13.1 0.0 1.5 1 1 0 1 1 1 0 WxcM-like, C-terminal NTP_transferase PF00483.18 EPA05326.1 - 9.9e-55 185.5 0.0 1.2e-54 185.2 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 EPA05326.1 - 1.5e-08 34.9 0.0 1.9e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.19 EPA05326.1 - 1.9e-07 30.2 15.4 1.1e-05 24.6 2.6 4.1 2 1 2 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EPA05326.1 - 9.9e-05 21.8 4.3 9.9e-05 21.8 3.0 4.0 2 1 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.7 EPA05326.1 - 0.018 13.6 1.0 0.029 12.9 0.7 1.4 1 0 0 1 1 1 0 L-fucokinase Methyltransf_21 PF05050.7 EPA05327.1 - 1.4e-25 90.1 0.6 2.1e-25 89.5 0.4 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_18 PF12847.2 EPA05327.1 - 2.9e-05 24.6 0.0 5.5e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EPA05327.1 - 0.0015 18.0 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.1 EPA05327.1 - 0.0039 16.9 0.0 0.0049 16.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 EPA05327.1 - 0.01 15.4 0.1 0.024 14.2 0.1 1.8 1 1 0 1 1 1 0 Met-10+ like-protein Methyltransf_3 PF01596.12 EPA05327.1 - 0.024 13.7 0.0 0.051 12.6 0.0 1.6 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_22 PF13383.1 EPA05327.1 - 0.11 12.0 0.3 0.15 11.5 0.2 1.2 1 0 0 1 1 1 0 Methyltransferase domain GATase PF00117.23 EPA05328.1 - 1.7e-16 60.2 0.0 2.4e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.12 EPA05328.1 - 2.6e-06 26.5 0.0 3.6e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 NAD synthase ThiI PF02568.9 EPA05328.1 - 0.00049 19.6 0.0 0.00072 19.0 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.11 EPA05328.1 - 0.00059 18.5 0.0 0.0008 18.0 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.16 EPA05328.1 - 0.0037 16.7 0.0 0.0067 15.9 0.0 1.4 1 0 0 1 1 1 1 Asparagine synthase Peptidase_C26 PF07722.8 EPA05328.1 - 0.0045 16.4 0.0 0.0065 15.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 Proteasome PF00227.21 EPA05328.1 - 0.062 12.5 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Proteasome subunit PAPS_reduct PF01507.14 EPA05328.1 - 0.097 12.4 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Hexapep PF00132.19 EPA05329.1 - 5.8e-13 47.6 11.5 2.9e-07 29.6 1.5 3.6 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EPA05329.1 - 2.6e-07 30.0 9.3 0.0043 16.5 2.3 3.7 2 2 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase Capsule_synth PF05159.9 EPA05332.1 - 1.8e-12 47.3 0.0 2.1e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Capsule polysaccharide biosynthesis protein Methyltransf_23 PF13489.1 EPA05334.1 - 1.3e-20 73.6 0.0 1.9e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA05334.1 - 1.2e-12 48.1 0.0 2.3e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA05334.1 - 2.5e-12 46.6 0.1 3.8e-12 46.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA05334.1 - 8.1e-09 35.8 0.0 1.3e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA05334.1 - 1.5e-05 25.5 0.0 2.5e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EPA05334.1 - 0.0004 20.7 0.0 0.0013 19.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MetW PF07021.7 EPA05334.1 - 0.00042 19.7 0.0 0.00053 19.4 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CheR PF01739.13 EPA05334.1 - 0.0034 16.7 0.1 0.0078 15.5 0.0 1.6 1 1 0 1 1 1 1 CheR methyltransferase, SAM binding domain MTS PF05175.9 EPA05334.1 - 0.0061 15.9 0.0 0.01 15.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.15 EPA05334.1 - 0.013 14.6 0.5 0.092 11.8 0.3 2.1 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.6 EPA05334.1 - 0.023 13.4 0.1 0.098 11.3 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) DREV PF05219.7 EPA05334.1 - 0.044 12.6 0.0 0.18 10.6 0.0 1.7 1 1 0 2 2 2 0 DREV methyltransferase Elf1 PF05129.8 EPA05334.1 - 0.047 13.3 0.6 0.093 12.4 0.4 1.5 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Methyltransf_32 PF13679.1 EPA05334.1 - 0.079 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Epimerase PF01370.16 EPA05335.1 - 5.5e-61 205.9 0.0 6.8e-61 205.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EPA05335.1 - 4.8e-19 68.3 0.0 6.8e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 EPA05335.1 - 5e-17 61.5 0.1 6.4e-17 61.1 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EPA05335.1 - 6.3e-14 51.4 0.0 3.5e-12 45.8 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.10 EPA05335.1 - 4.2e-13 48.8 0.0 2.4e-12 46.3 0.0 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 EPA05335.1 - 0.0013 18.7 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Epimerase_Csub PF13950.1 EPA05335.1 - 0.018 15.0 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose 4-epimerase C-term subunit Acetyltransf_3 PF13302.1 EPA05336.1 - 1.1e-12 48.2 0.1 1.5e-12 47.8 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EPA05336.1 - 2.8e-12 46.8 3.1 3.5e-12 46.5 2.2 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EPA05336.1 - 4e-12 45.9 0.1 7.9e-12 45.0 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EPA05336.1 - 1.9e-08 34.3 0.7 2.9e-08 33.7 0.5 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EPA05336.1 - 6.9e-07 29.2 0.0 8.5e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EPA05336.1 - 9.9e-07 28.4 0.0 2.1e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 EPA05336.1 - 1.5e-06 28.3 0.0 1.9e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EPA05336.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Epimerase PF01370.16 EPA05337.1 - 2.6e-55 187.4 0.3 3.2e-55 187.1 0.2 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EPA05337.1 - 1.3e-25 89.6 3.9 1.7e-25 89.2 2.7 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EPA05337.1 - 1.1e-20 73.7 0.0 1.3e-20 73.4 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 EPA05337.1 - 1.2e-18 67.0 4.8 6.2e-18 64.7 3.3 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 EPA05337.1 - 7.3e-14 51.2 0.3 1.8e-11 43.4 0.2 2.2 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 EPA05337.1 - 5.5e-09 36.1 0.0 1e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 EPA05337.1 - 1.6e-08 34.7 0.0 2.1e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding KR PF08659.5 EPA05337.1 - 1.3e-06 28.1 0.0 3e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 KR domain Saccharop_dh PF03435.13 EPA05337.1 - 0.00039 19.5 0.0 0.0007 18.6 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NmrA PF05368.8 EPA05337.1 - 0.00092 18.5 0.9 0.0045 16.2 0.3 2.1 2 1 0 2 2 2 1 NmrA-like family TrkA_N PF02254.13 EPA05337.1 - 0.0098 15.8 1.6 0.017 15.1 0.4 2.1 2 1 0 2 2 1 1 TrkA-N domain DapB_N PF01113.15 EPA05337.1 - 0.014 15.3 0.9 0.032 14.1 0.7 1.7 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Epimerase_Csub PF13950.1 EPA05337.1 - 0.017 15.0 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose 4-epimerase C-term subunit Shikimate_DH PF01488.15 EPA05337.1 - 0.018 15.1 0.3 0.053 13.6 0.2 1.8 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Swi5 PF07061.6 EPA05337.1 - 0.083 12.6 0.9 0.23 11.2 0.6 1.8 1 1 0 1 1 1 0 Swi5 NAD_binding_7 PF13241.1 EPA05337.1 - 0.17 12.1 0.8 0.37 11.0 0.1 2.0 2 2 0 2 2 2 0 Putative NAD(P)-binding HTH_40 PF14493.1 EPA05337.1 - 0.32 11.2 2.4 11 6.3 0.3 3.2 3 1 0 3 3 3 0 Helix-turn-helix domain ACPS PF01648.15 EPA05338.1 - 4.1e-16 58.8 0.3 4.6e-16 58.6 0.2 1.0 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily PMT_2 PF13231.1 EPA05339.1 - 8.5e-12 45.2 18.0 8.5e-12 45.2 12.5 3.1 3 1 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT PF02366.13 EPA05339.1 - 0.00039 19.8 20.4 0.00039 19.8 14.1 2.0 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase STT3 PF02516.9 EPA05339.1 - 0.0048 15.9 39.0 0.0036 16.3 25.5 1.8 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit DUF4293 PF14126.1 EPA05339.1 - 0.013 15.4 2.8 0.013 15.4 1.9 4.1 1 1 3 4 4 4 0 Domain of unknown function (DUF4293) EpsG PF14897.1 EPA05339.1 - 0.21 10.4 65.5 0.56 9.0 45.4 1.7 1 1 0 1 1 1 0 EpsG family NeuB PF03102.9 EPA05341.1 - 2.1e-19 69.6 0.4 2.6e-19 69.3 0.3 1.1 1 0 0 1 1 1 1 NeuB family adh_short PF00106.20 EPA05342.1 - 0.00016 21.6 0.0 0.00021 21.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EPA05342.1 - 0.0038 17.0 0.0 0.0055 16.5 0.0 1.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Chorismate_bind PF00425.13 EPA05342.1 - 0.11 11.7 0.0 0.13 11.5 0.0 1.0 1 0 0 1 1 1 0 chorismate binding enzyme Glycos_transf_1 PF00534.15 EPA05343.1 - 1.2e-19 70.3 0.0 1.5e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EPA05343.1 - 3.3e-07 30.5 0.0 4.3e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EPA05343.1 - 4.7e-07 29.9 0.0 5.7e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Med26 PF08711.6 EPA05343.1 - 0.025 14.0 0.7 0.04 13.4 0.1 1.6 2 0 0 2 2 2 0 TFIIS helical bundle-like domain Epimerase_2 PF02350.14 EPA05343.1 - 0.049 12.4 0.0 0.06 12.1 0.0 1.0 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase NIF PF03031.13 EPA05344.1 - 1e-05 25.2 0.2 3.3e-05 23.6 0.1 2.0 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Acid_PPase PF12689.2 EPA05344.1 - 2.8e-05 23.7 3.2 0.00029 20.5 1.6 2.6 1 1 0 1 1 1 1 Acid Phosphatase Acetyltransf_10 PF13673.1 EPA05344.1 - 0.00028 20.9 0.0 0.00077 19.5 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Glycos_transf_2 PF00535.21 EPA05345.1 - 1.5e-18 67.0 0.1 2e-18 66.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 EPA05345.1 - 0.065 13.0 0.0 0.087 12.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 RmlD_sub_bind PF04321.12 EPA05347.1 - 1.6e-73 247.1 0.0 1.8e-73 246.9 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 EPA05347.1 - 1.3e-21 77.1 0.0 2.1e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EPA05347.1 - 1.5e-08 33.7 0.0 4.5e-08 32.1 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EPA05347.1 - 1.6e-08 33.7 0.0 2e-06 26.9 0.0 2.3 1 1 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.10 EPA05347.1 - 1.9e-07 30.3 0.1 6.1e-06 25.3 0.1 2.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 EPA05347.1 - 1.6e-05 24.9 0.0 2.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding DapB_N PF01113.15 EPA05347.1 - 0.11 12.3 0.0 0.59 10.0 0.0 2.0 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus CTP_transf_3 PF02348.14 EPA05348.1 - 3.5e-20 72.5 0.1 4.3e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase KH_5 PF13184.1 EPA05348.1 - 0.046 13.5 0.3 0.14 12.0 0.2 1.8 1 0 0 1 1 1 0 NusA-like KH domain MAF_flag10 PF01973.13 EPA05350.1 - 2.9e-19 69.1 0.1 6.5e-19 68.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function DUF115 Asn_synthase PF00733.16 EPA05351.1 - 3.4e-06 26.7 0.0 3.8e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.11 EPA05351.1 - 0.0099 14.4 0.0 0.013 14.0 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase ATP_bind_3 PF01171.15 EPA05351.1 - 0.017 14.6 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 PP-loop family Vps4_C PF09336.5 EPA05351.1 - 0.052 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain NAD_synthase PF02540.12 EPA05351.1 - 0.1 11.4 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 NAD synthase CTP_transf_3 PF02348.14 EPA05352.1 - 6.6e-30 104.3 0.8 8.8e-30 103.9 0.6 1.2 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.2 EPA05352.1 - 0.00033 20.7 0.0 0.00049 20.2 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain DegT_DnrJ_EryC1 PF01041.12 EPA05354.1 - 9.8e-88 294.6 0.0 1.1e-87 294.4 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 EPA05354.1 - 0.00011 21.1 0.0 0.00018 20.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 EPA05354.1 - 0.00066 18.7 0.0 0.0011 18.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II DUF1439 PF07273.7 EPA05354.1 - 0.032 13.9 0.7 0.067 12.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1439) DUF2294 PF10057.4 EPA05354.1 - 0.05 13.2 0.2 0.097 12.3 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) MaoC_dehydratas PF01575.14 EPA05355.1 - 1.8e-23 82.2 0.0 2e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.1 EPA05355.1 - 3e-10 39.9 0.0 8.1e-10 38.5 0.0 1.6 1 1 0 1 1 1 1 N-terminal half of MaoC dehydratase 4HBT PF03061.17 EPA05355.1 - 0.012 15.6 0.0 0.02 15.0 0.0 1.3 1 0 0 1 1 1 0 Thioesterase superfamily Histidinol_dh PF00815.15 EPA05355.1 - 0.014 14.0 0.0 0.015 13.9 0.0 1.1 1 0 0 1 1 1 0 Histidinol dehydrogenase AAA PF00004.24 EPA05356.1 - 3.2e-60 202.0 0.0 1.6e-43 148.0 0.0 2.2 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EPA05356.1 - 8.8e-07 29.0 0.1 6e-05 23.1 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.9 EPA05356.1 - 1.9e-06 27.9 0.0 4.5e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 EPA05356.1 - 1.8e-05 24.8 0.0 0.00034 20.7 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EPA05356.1 - 2.5e-05 24.0 0.2 0.0014 18.4 0.1 3.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 EPA05356.1 - 0.0001 21.1 0.0 0.00018 20.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_33 PF13671.1 EPA05356.1 - 0.00017 21.5 0.0 0.0004 20.2 0.0 1.6 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.1 EPA05356.1 - 0.00086 20.1 0.2 0.0033 18.2 0.0 2.0 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 EPA05356.1 - 0.00097 18.2 0.0 0.0034 16.4 0.0 2.0 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 EPA05356.1 - 0.001 18.4 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.21 EPA05356.1 - 0.0016 17.9 0.1 0.011 15.2 0.0 2.2 3 0 0 3 3 2 1 Sigma-54 interaction domain AAA_14 PF13173.1 EPA05356.1 - 0.0028 17.5 0.0 0.0054 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EPA05356.1 - 0.0028 17.3 1.2 0.026 14.2 0.1 2.5 3 0 0 3 3 2 1 Part of AAA domain NACHT PF05729.7 EPA05356.1 - 0.0046 16.6 0.1 0.17 11.5 0.1 2.4 1 1 1 2 2 2 1 NACHT domain AAA_25 PF13481.1 EPA05356.1 - 0.0072 15.7 1.1 1.7 8.0 0.2 2.5 2 1 0 3 3 2 1 AAA domain PhoH PF02562.11 EPA05356.1 - 0.013 14.7 0.1 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_18 PF13238.1 EPA05356.1 - 0.024 14.9 0.2 0.18 12.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 EPA05356.1 - 0.027 13.5 0.0 0.049 12.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.17 EPA05356.1 - 0.038 14.1 0.0 0.074 13.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.16 EPA05356.1 - 0.053 12.6 0.5 0.14 11.3 0.1 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 EPA05356.1 - 0.054 13.4 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EPA05356.1 - 0.06 13.0 0.0 11 5.6 0.0 3.2 2 2 1 3 3 3 0 Archaeal ATPase Sigma54_activ_2 PF14532.1 EPA05356.1 - 0.066 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain KaiC PF06745.8 EPA05356.1 - 0.071 12.2 0.0 0.32 10.0 0.0 2.0 2 0 0 2 2 2 0 KaiC Bac_DnaA PF00308.13 EPA05356.1 - 0.076 12.6 0.0 1.1 8.8 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein ABC_tran PF00005.22 EPA05356.1 - 0.11 12.7 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter CPT PF07931.7 EPA05356.1 - 0.11 12.0 0.0 0.31 10.6 0.0 1.6 2 0 0 2 2 1 0 Chloramphenicol phosphotransferase-like protein AAA_30 PF13604.1 EPA05356.1 - 0.14 11.7 0.1 0.37 10.3 0.0 1.7 2 0 0 2 2 1 0 AAA domain ResIII PF04851.10 EPA05356.1 - 0.17 11.7 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NB-ARC PF00931.17 EPA05356.1 - 0.18 10.6 0.0 0.31 9.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Yippee-Mis18 PF03226.9 EPA05357.1 - 0.12 12.4 0.4 0.15 12.1 0.2 1.3 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly CTDII PF01556.13 EPA05358.1 - 5.3e-25 87.1 9.3 1.2e-22 79.5 0.6 2.6 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 EPA05358.1 - 7.1e-15 54.8 19.5 1.3e-14 53.9 13.5 1.4 1 0 0 1 1 1 1 DnaJ central domain dCMP_cyt_deam_1 PF00383.17 EPA05358.1 - 0.69 9.5 4.4 8.9 6.0 3.1 2.2 1 1 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region Cytochrom_c3_2 PF14537.1 EPA05358.1 - 3.7 7.9 8.4 9.3 6.6 5.8 1.7 1 1 0 1 1 1 0 Cytochrome c3 GatB_N PF02934.10 EPA05359.1 - 4.2e-72 242.4 0.1 6.7e-72 241.7 0.1 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.13 EPA05359.1 - 4.9e-19 68.5 9.4 4.9e-19 68.5 6.5 2.1 2 0 0 2 2 2 1 GatB domain EnY2 PF10163.4 EPA05359.1 - 0.047 13.6 3.8 0.13 12.1 2.1 2.3 2 0 0 2 2 2 0 Transcription factor e(y)2 p25-alpha PF05517.7 EPA05359.1 - 0.18 12.0 10.1 0.45 10.7 1.6 2.5 2 0 0 2 2 2 0 p25-alpha NT5C PF06941.7 EPA05361.1 - 1.9e-11 43.8 1.8 2.5e-11 43.4 1.3 1.1 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Asparaginase PF00710.15 EPA05362.1 - 1.4e-79 267.2 0.0 1.7e-79 266.9 0.0 1.0 1 0 0 1 1 1 1 Asparaginase CCDC155 PF14662.1 EPA05363.1 - 0.00091 18.8 0.3 0.001 18.7 0.2 1.0 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 Ax_dynein_light PF10211.4 EPA05363.1 - 0.0042 16.9 1.5 0.005 16.7 1.0 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain Retrotrans_gag PF03732.12 EPA05363.1 - 0.048 13.7 0.8 0.35 10.9 0.3 1.9 1 1 1 2 2 2 0 Retrotransposon gag protein TMF_TATA_bd PF12325.3 EPA05363.1 - 0.061 13.0 0.3 0.069 12.8 0.2 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 EPA05363.1 - 0.15 11.9 0.6 0.24 11.2 0.1 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF1059 PF06348.6 EPA05364.1 - 8.5e-14 51.1 0.5 9.3e-14 50.9 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) IFT57 PF10498.4 EPA05364.1 - 0.086 11.5 0.1 0.092 11.4 0.1 1.0 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Pyr_redox_2 PF07992.9 EPA05365.1 - 1.2e-30 106.9 6.8 4.1e-29 101.9 4.7 3.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EPA05365.1 - 2e-18 66.5 1.1 1.4e-16 60.6 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EPA05365.1 - 1.6e-13 51.2 0.2 8e-11 42.3 0.0 2.9 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EPA05365.1 - 1.3e-07 30.9 2.0 0.00031 19.7 0.0 2.5 2 1 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.17 EPA05365.1 - 6.4e-07 28.5 2.1 0.0079 15.1 0.0 3.4 3 1 0 3 3 3 2 Glucose inhibited division protein A K_oxygenase PF13434.1 EPA05365.1 - 4.2e-06 25.9 0.1 0.046 12.6 0.0 3.1 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.12 EPA05365.1 - 0.00012 21.2 0.0 0.0036 16.4 0.0 2.4 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.14 EPA05365.1 - 0.00022 20.4 0.7 0.22 10.5 0.0 2.7 2 1 1 3 3 3 2 FAD binding domain FAD_binding_2 PF00890.19 EPA05365.1 - 0.00097 18.0 4.3 0.0078 15.1 0.1 3.4 2 1 2 4 4 4 1 FAD binding domain FAD_oxidored PF12831.2 EPA05365.1 - 0.0024 16.9 0.1 0.0046 16.0 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EPA05365.1 - 0.0059 16.6 0.2 0.033 14.1 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EPA05365.1 - 0.0062 15.0 2.2 0.15 10.4 0.0 3.0 3 1 1 4 4 4 1 HI0933-like protein Lycopene_cycl PF05834.7 EPA05365.1 - 0.0066 15.4 0.4 0.91 8.3 0.0 2.8 3 0 0 3 3 3 1 Lycopene cyclase protein NAD_binding_7 PF13241.1 EPA05365.1 - 0.0068 16.6 0.5 0.051 13.8 0.1 2.3 2 1 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_9 PF13454.1 EPA05365.1 - 0.01 15.6 6.2 0.71 9.6 0.0 3.3 3 0 0 3 3 3 0 FAD-NAD(P)-binding XdhC_C PF13478.1 EPA05365.1 - 0.045 14.0 0.0 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 XdhC Rossmann domain MAS20 PF02064.10 EPA05365.1 - 0.13 12.1 0.2 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 MAS20 protein import receptor NERD PF08378.6 EPA05366.1 - 0.012 15.8 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 0 Nuclease-related domain zf-C2HC_2 PF13913.1 EPA05367.1 - 0.011 15.3 0.2 0.011 15.3 0.2 1.9 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-RING_5 PF14634.1 EPA05367.1 - 0.014 15.0 2.3 2.1 8.1 0.2 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EPA05367.1 - 0.017 15.1 1.2 0.91 9.6 0.0 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EPA05367.1 - 0.047 13.3 2.5 3.5 7.3 0.2 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EPA05367.1 - 0.13 12.1 1.6 1.4 8.8 0.1 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-HYPF PF07503.7 EPA05367.1 - 0.33 10.3 2.8 4.6 6.7 0.1 2.2 2 0 0 2 2 2 0 HypF finger zf-DBF PF07535.7 EPA05367.1 - 0.56 9.9 0.2 0.56 9.9 0.2 2.1 2 0 0 2 2 2 0 DBF zinc finger Response_reg PF00072.19 EPA05369.1 - 1.9e-12 47.1 0.1 2.2e-12 46.9 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain DUF4138 PF13595.1 EPA05369.1 - 0.026 13.4 0.0 0.037 12.9 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4138) UFD1 PF03152.9 EPA05369.1 - 0.076 12.1 0.1 0.09 11.9 0.1 1.2 1 1 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 MCPsignal PF00015.16 EPA05370.1 - 3.2e-08 33.3 2.7 4.6e-08 32.8 1.8 1.3 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1798 PF08807.5 EPA05370.1 - 0.075 12.7 0.1 0.41 10.3 0.0 2.1 2 0 0 2 2 2 0 Bacterial domain of unknown function (DUF1798) Ribosomal_S13 PF00416.17 EPA05370.1 - 9.1 6.7 8.1 1.1e+02 3.3 5.6 2.5 1 1 0 1 1 1 0 Ribosomal protein S13/S18 ATP-synt_B PF00430.13 EPA05371.1 - 0.049 13.4 0.1 0.049 13.4 0.1 1.5 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) Med28 PF11594.3 EPA05372.1 - 0.05 13.8 0.8 0.065 13.4 0.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 28 PMSR PF01625.16 EPA05372.1 - 0.051 13.4 0.1 0.057 13.2 0.1 1.0 1 0 0 1 1 1 0 Peptide methionine sulfoxide reductase DUF2543 PF10820.3 EPA05372.1 - 0.052 13.5 1.0 0.068 13.1 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2543) DUF4579 PF15158.1 EPA05372.1 - 0.13 11.7 0.1 0.15 11.5 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4579) RWD PF05773.17 EPA05373.1 - 0.024 14.5 0.7 0.033 14.0 0.5 1.2 1 0 0 1 1 1 0 RWD domain SMC_Nse1 PF07574.8 EPA05373.1 - 0.051 13.1 1.0 0.058 13.0 0.7 1.1 1 0 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex N-SET PF11764.3 EPA05373.1 - 0.08 12.8 1.5 0.091 12.6 1.0 1.1 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component N DUF1325 PF07039.6 EPA05373.1 - 0.1 12.2 0.8 0.12 12.0 0.5 1.1 1 0 0 1 1 1 0 SGF29 tudor-like domain Aurora-A_bind PF09041.5 EPA05373.1 - 0.12 12.1 1.9 0.2 11.4 0.7 1.8 1 1 0 2 2 2 0 Aurora-A binding HD_3 PF13023.1 EPA05374.1 - 6.4e-36 123.5 0.1 7.6e-36 123.3 0.1 1.0 1 0 0 1 1 1 1 HD domain HD PF01966.17 EPA05374.1 - 0.0013 18.7 0.0 0.0027 17.7 0.0 1.5 1 1 0 1 1 1 1 HD domain DUF4130 PF13566.1 EPA05374.1 - 0.0096 15.4 0.1 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4130 Bystin PF05291.6 EPA05374.1 - 0.027 13.4 0.0 0.049 12.5 0.0 1.4 1 0 0 1 1 1 0 Bystin Cob_adeno_trans PF01923.13 EPA05375.1 - 2.2e-57 193.3 0.0 2.6e-57 193.1 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase HAS-barrel PF09378.5 EPA05375.1 - 0.053 13.4 0.5 5.2 7.0 0.0 3.0 2 1 1 3 3 3 0 HAS barrel domain Topoisom_I PF01028.15 EPA05375.1 - 0.072 12.1 0.1 0.092 11.8 0.0 1.3 1 1 0 1 1 1 0 Eukaryotic DNA topoisomerase I, catalytic core ILVD_EDD PF00920.16 EPA05377.1 - 1.9e-42 145.3 0.0 2.1e-42 145.2 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family DUF1263 PF06882.7 EPA05377.1 - 0.058 13.0 0.0 0.12 12.0 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1263) DUF4423 PF14394.1 EPA05380.1 - 0.00012 21.6 0.6 0.00021 20.9 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) HTH_45 PF14947.1 EPA05380.1 - 0.00013 21.7 0.3 0.0003 20.5 0.2 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_34 PF13601.1 EPA05380.1 - 0.00064 19.6 0.4 0.0012 18.8 0.3 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.14 EPA05380.1 - 0.00085 18.9 0.2 0.0013 18.3 0.1 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB TFIIE_alpha PF02002.12 EPA05380.1 - 0.0059 16.0 0.9 0.0099 15.3 0.6 1.4 1 0 0 1 1 1 1 TFIIE alpha subunit Rio2_N PF09202.6 EPA05380.1 - 0.007 16.4 0.2 0.047 13.7 0.0 2.2 2 0 0 2 2 2 1 Rio2, N-terminal MarR_2 PF12802.2 EPA05380.1 - 0.029 14.0 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 MarR family HTH_27 PF13463.1 EPA05380.1 - 0.035 14.4 0.1 0.054 13.8 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain DUF3135 PF11333.3 EPA05380.1 - 0.046 13.8 0.5 0.14 12.3 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3135) DUF2317 PF10079.4 EPA05380.1 - 0.063 11.8 0.1 0.086 11.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2317) HemN_C PF06969.11 EPA05380.1 - 0.088 12.8 0.1 7.9 6.6 0.1 2.5 2 0 0 2 2 2 0 HemN C-terminal domain DUF2250 PF10007.4 EPA05380.1 - 0.098 12.5 1.4 0.16 11.9 1.0 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) CDC37_C PF08564.5 EPA05380.1 - 0.3 10.9 3.3 0.52 10.1 2.3 1.3 1 0 0 1 1 1 0 Cdc37 C terminal domain Rieske PF00355.21 EPA05381.1 - 1.3e-15 56.7 0.0 1.4e-15 56.5 0.0 1.0 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 EPA05381.1 - 1e-13 50.9 0.0 1.2e-13 50.7 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain AATF-Che1 PF13339.1 EPA05382.1 - 0.0014 18.7 3.3 0.0019 18.3 2.3 1.2 1 0 0 1 1 1 1 Apoptosis antagonizing transcription factor DUF948 PF06103.6 EPA05382.1 - 0.0045 16.8 0.9 0.022 14.5 0.3 2.1 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF948) Reo_sigmaC PF04582.7 EPA05382.1 - 0.012 14.7 0.4 0.048 12.8 0.4 1.5 1 1 0 1 1 1 0 Reovirus sigma C capsid protein Syntaxin-6_N PF09177.6 EPA05382.1 - 0.03 14.7 3.1 0.12 12.8 0.9 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal PH_4 PF15404.1 EPA05382.1 - 0.036 13.5 0.6 0.044 13.3 0.4 1.0 1 0 0 1 1 1 0 Pleckstrin homology domain Orthopox_A5L PF06193.6 EPA05382.1 - 0.048 13.5 1.9 0.089 12.7 0.6 1.8 1 1 1 2 2 2 0 Orthopoxvirus A5L protein-like DUF4375 PF14300.1 EPA05382.1 - 0.049 13.6 0.0 0.063 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4375) Baculo_PEP_C PF04513.7 EPA05382.1 - 0.12 12.1 0.8 0.19 11.5 0.5 1.4 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin PF00804.20 EPA05382.1 - 0.32 11.1 6.5 1.9 8.6 4.5 1.9 1 1 0 1 1 1 0 Syntaxin Epimerase PF01370.16 EPA05383.1 - 2e-25 89.6 0.0 2.6e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EPA05383.1 - 9.3e-14 51.8 0.0 1.1e-13 51.5 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EPA05383.1 - 9.4e-14 50.9 0.0 3.8e-11 42.4 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 EPA05383.1 - 2.6e-13 49.2 0.2 6.8e-13 47.9 0.1 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EPA05383.1 - 2.5e-08 33.1 0.0 2.3e-07 30.0 0.0 1.9 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 EPA05383.1 - 3.2e-06 26.2 0.6 0.00042 19.3 0.3 2.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 EPA05383.1 - 2.8e-05 23.4 0.0 0.00053 19.3 0.0 2.1 2 0 0 2 2 2 1 NmrA-like family PRTP PF01366.13 EPA05383.1 - 0.029 12.3 0.0 0.035 12.0 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Sarcolipin PF05366.6 EPA05383.1 - 0.047 13.1 0.1 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 Sarcolipin DapB_N PF01113.15 EPA05383.1 - 0.072 13.0 0.0 0.26 11.2 0.0 1.9 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.20 EPA05383.1 - 0.094 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase NAD_synthase PF02540.12 EPA05384.1 - 6.2e-78 261.0 1.8 7.2e-78 260.8 1.3 1.0 1 0 0 1 1 1 1 NAD synthase tRNA_Me_trans PF03054.11 EPA05384.1 - 0.00014 20.5 0.0 0.01 14.4 0.0 2.4 2 1 0 2 2 2 1 tRNA methyl transferase SpoIIID PF12116.3 EPA05384.1 - 0.0014 18.4 1.2 2.6 8.0 0.0 3.3 2 1 0 3 3 3 1 Stage III sporulation protein D Asn_synthase PF00733.16 EPA05384.1 - 0.0041 16.6 0.0 0.0056 16.2 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase HTH_23 PF13384.1 EPA05384.1 - 0.0046 16.5 0.1 4 7.2 0.0 2.9 3 0 0 3 3 3 2 Homeodomain-like domain QueC PF06508.8 EPA05384.1 - 0.0068 15.7 0.0 0.016 14.5 0.0 1.7 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.9 EPA05384.1 - 0.013 14.9 0.1 0.11 11.8 0.0 2.2 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) Phage_terminase PF10668.4 EPA05384.1 - 0.041 13.6 0.9 0.51 10.1 0.0 2.8 2 1 1 3 3 3 0 Phage terminase small subunit ATP_bind_3 PF01171.15 EPA05384.1 - 0.051 13.0 0.0 0.093 12.2 0.0 1.5 1 0 0 1 1 1 0 PP-loop family RuvB_C PF05491.8 EPA05384.1 - 0.082 12.5 2.3 31 4.2 0.1 3.3 3 0 0 3 3 3 0 Holliday junction DNA helicase ruvB C-terminus DUF2316 PF10078.4 EPA05384.1 - 0.083 12.8 0.1 0.79 9.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) Peptidase_C25 PF01364.13 EPA05384.1 - 0.1 11.5 0.1 0.11 11.3 0.1 1.2 1 0 0 1 1 1 0 Peptidase family C25 Response_reg PF00072.19 EPA05385.1 - 3.3e-05 23.8 0.1 7.1e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain zf-Di19 PF05605.7 EPA05385.1 - 0.0032 17.5 2.9 0.0032 17.5 2.0 2.8 1 1 1 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding DZR PF12773.2 EPA05385.1 - 0.0035 17.1 20.3 0.55 10.0 6.3 3.3 2 1 2 4 4 4 3 Double zinc ribbon zinc-ribbons_6 PF07191.7 EPA05385.1 - 0.019 14.7 19.6 0.089 12.5 2.1 3.4 2 1 1 4 4 4 0 zinc-ribbons Prok-RING_1 PF14446.1 EPA05385.1 - 0.039 13.6 14.1 0.23 11.2 0.5 3.9 3 1 2 5 5 5 0 Prokaryotic RING finger family 1 Spt4 PF06093.8 EPA05385.1 - 0.17 11.7 0.2 0.17 11.7 0.2 3.4 1 1 2 3 3 3 0 Spt4/RpoE2 zinc finger HypA PF01155.14 EPA05385.1 - 0.27 10.9 15.3 0.38 10.4 1.5 3.1 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family FYVE_2 PF02318.11 EPA05385.1 - 0.33 10.8 14.3 0.39 10.6 3.6 2.3 1 1 1 2 2 2 0 FYVE-type zinc finger zf-IS66 PF13005.2 EPA05385.1 - 0.34 10.9 0.0 0.34 10.9 0.0 3.7 5 0 0 5 5 5 0 zinc-finger binding domain of transposase IS66 zf-C3HC4_3 PF13920.1 EPA05385.1 - 0.46 10.1 13.4 4.3 7.0 1.1 3.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) UPF0547 PF10571.4 EPA05385.1 - 1.4 8.6 11.8 0.093 12.4 0.6 3.7 3 1 0 3 3 2 0 Uncharacterised protein family UPF0547 zf-RING_4 PF14570.1 EPA05385.1 - 1.6 8.3 17.3 4.7 6.8 0.2 3.3 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain PhnA_Zn_Ribbon PF08274.7 EPA05385.1 - 1.8 8.4 19.3 1.3 8.8 0.2 4.5 5 0 0 5 5 4 0 PhnA Zinc-Ribbon zinc_ribbon_5 PF13719.1 EPA05385.1 - 1.9 8.1 20.3 0.35 10.4 0.2 5.1 5 0 0 5 5 5 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA05385.1 - 2.1 8.1 20.8 0.38 10.4 0.2 5.1 5 0 0 5 5 5 0 zinc-ribbon domain Med27 PF11571.3 EPA05385.1 - 2.2 8.4 8.9 0.18 11.9 0.3 3.1 3 0 0 3 3 3 0 Mediator complex subunit 27 Rubredoxin PF00301.15 EPA05385.1 - 4.5 7.2 11.4 2.6 7.9 0.1 4.3 3 2 1 4 4 4 0 Rubredoxin RNHCP PF12647.2 EPA05385.1 - 4.8 7.0 9.4 5.3 6.9 4.2 2.5 1 1 1 2 2 2 0 RNHCP domain C1_4 PF07975.7 EPA05385.1 - 6.7 6.7 18.7 16 5.5 5.1 4.1 2 2 0 2 2 2 0 TFIIH C1-like domain Zn-ribbon_8 PF09723.5 EPA05385.1 - 6.9 6.7 22.2 3.6 7.6 0.5 5.3 2 2 3 5 5 5 0 Zinc ribbon domain Response_reg PF00072.19 EPA05386.1 - 6.4e-17 61.5 0.2 7.3e-17 61.3 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain PrpR_N PF06506.6 EPA05386.1 - 0.048 13.0 0.1 0.46 9.8 0.0 1.9 2 0 0 2 2 2 0 Propionate catabolism activator AdoHcyase_NAD PF00670.16 EPA05387.1 - 2.8e-52 176.8 3.8 3.3e-52 176.6 0.6 2.2 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.12 EPA05387.1 - 1.7e-49 168.2 0.3 2.1e-49 167.9 0.2 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase 2-Hacid_dh_C PF02826.14 EPA05387.1 - 8.7e-10 38.0 0.1 2.2e-09 36.6 0.1 1.7 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 EPA05387.1 - 2.6e-06 26.9 0.0 5.1e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 EPA05387.1 - 0.0022 17.9 0.0 0.0067 16.4 0.0 1.8 1 0 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.15 EPA05387.1 - 0.0042 17.1 0.2 0.058 13.4 0.1 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 EPA05387.1 - 0.0085 15.7 2.1 0.025 14.2 0.3 2.4 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.14 EPA05387.1 - 0.016 14.3 0.3 0.2 10.7 0.4 2.5 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain UDPG_MGDP_dh_N PF03721.9 EPA05387.1 - 0.041 13.2 0.5 0.093 12.0 0.4 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF364 PF04016.7 EPA05387.1 - 0.058 12.7 0.0 0.15 11.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF364) Syntaxin-6_N PF09177.6 EPA05388.1 - 0.032 14.6 0.4 0.038 14.3 0.2 1.1 1 0 0 1 1 1 0 Syntaxin 6, N-terminal FUSC-like PF12805.2 EPA05388.1 - 0.043 12.7 0.1 0.05 12.5 0.1 1.2 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS Pterin_4a PF01329.14 EPA05388.1 - 0.081 12.6 0.3 0.14 11.9 0.2 1.5 1 1 0 1 1 1 0 Pterin 4 alpha carbinolamine dehydratase CoA_binding_2 PF13380.1 EPA05389.1 - 9.5e-36 122.4 0.0 1.1e-35 122.2 0.0 1.0 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.14 EPA05389.1 - 3.2e-07 30.7 0.0 6e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 CoA binding domain Glyco_hydro_57 PF03065.10 EPA05389.1 - 0.052 12.4 0.0 0.083 11.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Phage_GPA PF05840.8 EPA05389.1 - 0.089 11.4 0.1 0.15 10.7 0.0 1.3 2 0 0 2 2 2 0 Bacteriophage replication gene A protein (GPA) SpoU_sub_bind PF08032.7 EPA05389.1 - 0.092 12.9 0.1 0.21 11.7 0.1 1.5 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding PAS_9 PF13426.1 EPA05391.1 - 6e-45 151.8 0.1 1.4e-21 76.8 0.0 3.1 3 0 0 3 3 3 2 PAS domain HATPase_c PF02518.21 EPA05391.1 - 1.5e-31 108.4 1.1 3.4e-31 107.2 0.3 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.19 EPA05391.1 - 5.5e-23 80.8 0.0 7.1e-11 41.8 0.0 2.8 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.5 EPA05391.1 - 5.9e-20 71.3 0.0 1.5e-09 37.8 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.6 EPA05391.1 - 1.3e-19 70.0 1.2 4.2e-10 39.5 0.0 2.8 2 0 0 2 2 2 2 PAS fold HisKA PF00512.20 EPA05391.1 - 5.5e-13 48.7 0.2 7.2e-11 41.9 0.0 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.20 EPA05391.1 - 7.1e-11 42.1 2.1 1.7e-10 40.9 1.0 2.1 2 0 0 2 2 2 1 HAMP domain PAS_8 PF13188.1 EPA05391.1 - 4e-08 32.8 0.0 0.00043 20.0 0.0 2.7 2 0 0 2 2 2 2 PAS domain HATPase_c_3 PF13589.1 EPA05391.1 - 7.6e-05 22.3 0.3 0.00035 20.2 0.2 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 EPA05391.1 - 0.0022 17.8 0.0 0.02 14.7 0.0 2.3 1 1 0 1 1 1 1 Histidine kinase-like ATPase domain DUF1397 PF07165.6 EPA05391.1 - 0.0096 15.1 0.3 0.021 14.0 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1397) PAS_7 PF12860.2 EPA05391.1 - 0.015 15.2 0.7 24 4.9 0.0 4.1 4 0 0 4 4 4 0 PAS fold YlbD_coat PF14071.1 EPA05391.1 - 3 7.9 11.3 0.53 10.3 0.3 3.4 2 1 0 3 3 3 0 Putative coat protein MMR_HSR1_C PF08438.5 EPA05392.1 - 9.4e-33 112.7 0.0 2.1e-32 111.5 0.0 1.6 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 EPA05392.1 - 2.5e-15 56.4 0.1 9.4e-15 54.5 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.16 EPA05392.1 - 1.3e-07 31.3 0.0 2.6e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 EPA05392.1 - 4.3e-05 22.8 0.1 0.0036 16.6 0.0 2.8 2 1 1 3 3 3 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EPA05392.1 - 0.00031 20.6 0.2 0.067 13.0 0.0 2.8 2 1 0 3 3 3 1 Dynamin family GTP_EFTU PF00009.22 EPA05392.1 - 0.00093 18.6 0.3 1.8 7.9 0.0 2.8 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain BPL_LplA_LipB PF03099.14 EPA05393.1 - 2.1e-22 79.4 0.1 3.3e-20 72.3 0.0 2.1 2 0 0 2 2 2 2 Biotin/lipoate A/B protein ligase family BPL_C PF02237.12 EPA05393.1 - 1.3e-09 37.5 1.2 2.7e-09 36.5 0.9 1.6 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain Sec15 PF04091.7 EPA05393.1 - 0.009 15.3 0.1 0.013 14.8 0.1 1.2 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like HTH_11 PF08279.7 EPA05393.1 - 0.024 14.2 0.5 0.081 12.5 0.4 2.0 1 0 0 1 1 1 0 HTH domain tRNA-synt_1g PF09334.6 EPA05394.1 - 6.6e-89 298.2 1.0 7.4e-89 298.1 0.7 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 EPA05394.1 - 3.9e-16 58.1 0.5 1.5e-08 33.1 0.0 3.0 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 EPA05394.1 - 9e-06 25.0 0.2 1.5e-05 24.3 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.14 EPA05394.1 - 0.0024 16.7 0.3 0.3 9.8 0.0 2.4 2 1 1 3 3 3 2 tRNA synthetases class I (R) tRNA-synt_1f PF01921.13 EPA05394.1 - 0.017 13.8 0.1 0.14 10.8 0.1 2.0 2 1 0 2 2 2 0 tRNA synthetases class I (K) zf-ribbon_3 PF13248.1 EPA05394.1 - 0.031 13.5 6.6 2.8 7.2 4.6 2.5 1 1 0 1 1 1 0 zinc-ribbon domain NRDD PF13597.1 EPA05394.1 - 0.1 10.6 1.0 3.5 5.6 1.3 2.0 1 1 1 2 2 2 0 Anaerobic ribonucleoside-triphosphate reductase RecR PF02132.10 EPA05394.1 - 2.7 7.5 6.0 1.9 7.9 1.2 2.4 2 0 0 2 2 2 0 RecR protein TPR_11 PF13414.1 EPA05396.1 - 1e-08 34.6 1.6 0.0002 20.9 0.0 2.4 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 EPA05396.1 - 2e-07 30.3 0.0 0.035 14.0 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 EPA05396.1 - 3.9e-06 26.2 0.2 0.48 10.1 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 EPA05396.1 - 5.6e-05 23.0 0.4 3.2 8.1 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EPA05396.1 - 0.0012 19.3 0.0 11 6.9 0.0 3.4 1 1 2 3 3 3 1 Tetratricopeptide repeat Coatomer_E PF04733.9 EPA05396.1 - 0.0019 17.4 0.1 0.003 16.8 0.1 1.2 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_8 PF13181.1 EPA05396.1 - 0.0019 17.8 1.5 0.29 11.0 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 EPA05396.1 - 0.0024 18.4 0.0 0.086 13.5 0.0 2.5 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 EPA05396.1 - 0.0042 17.3 0.0 0.31 11.4 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 EPA05396.1 - 0.028 14.8 1.3 0.76 10.3 0.0 3.8 5 0 0 5 5 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EPA05396.1 - 0.032 14.1 0.0 19 5.1 0.0 3.1 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 EPA05396.1 - 0.044 14.0 0.0 0.23 11.6 0.0 1.9 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation Response_reg PF00072.19 EPA05397.1 - 2.2e-24 85.6 0.2 2.5e-24 85.4 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain AAA_14 PF13173.1 EPA05397.1 - 0.27 11.1 3.8 0.82 9.5 1.0 2.4 2 1 0 2 2 2 0 AAA domain tRNA-synt_1e PF01406.14 EPA05398.1 - 9e-125 415.7 1.4 9e-125 415.7 0.9 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 EPA05398.1 - 1.4e-15 56.8 2.8 2e-09 36.6 0.6 2.6 2 1 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.6 EPA05398.1 - 4.1e-09 36.5 0.2 1.3e-08 34.9 0.1 1.8 1 0 0 1 1 1 1 DALR domain tRNA-synt_1 PF00133.17 EPA05398.1 - 1.5e-08 33.1 0.1 3.4e-06 25.3 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.13 EPA05398.1 - 6.8e-08 31.5 0.1 0.0024 16.5 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (K) ERp29 PF07749.7 EPA05398.1 - 0.31 11.6 5.1 20 5.9 0.1 3.6 2 2 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain tRNA-synt_1c PF00749.16 EPA05398.1 - 1.2 7.7 9.5 0.41 9.2 1.7 3.1 3 1 0 3 3 3 0 tRNA synthetases class I (E and Q), catalytic domain DZR PF12773.2 EPA05399.1 - 0.0026 17.5 0.4 0.0038 16.9 0.3 1.3 1 0 0 1 1 1 1 Double zinc ribbon GATA PF00320.22 EPA05399.1 - 0.0039 16.5 5.7 0.0049 16.1 3.9 1.2 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 EPA05399.1 - 0.012 14.8 0.5 0.016 14.5 0.4 1.2 1 0 0 1 1 1 0 TFIIB zinc-binding DUF2296 PF10058.4 EPA05399.1 - 0.016 14.9 1.4 0.038 13.7 0.9 1.6 1 1 0 1 1 1 0 Predicted integral membrane metal-binding protein (DUF2296) Enterotoxin_ST PF02048.11 EPA05399.1 - 0.019 15.2 1.4 0.025 14.8 1.0 1.2 1 0 0 1 1 1 0 Heat-stable enterotoxin ST C1_1 PF00130.17 EPA05399.1 - 0.019 14.6 1.4 0.027 14.2 0.9 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE PF01363.16 EPA05399.1 - 0.042 13.7 1.2 0.057 13.3 0.8 1.2 1 0 0 1 1 1 0 FYVE zinc finger DRP PF06044.7 EPA05399.1 - 0.045 12.7 0.6 0.047 12.6 0.4 1.0 1 0 0 1 1 1 0 Dam-replacing family DUF845 PF05820.6 EPA05399.1 - 0.069 12.8 0.2 0.077 12.7 0.1 1.1 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF845) zf-B_box PF00643.19 EPA05399.1 - 0.077 12.8 2.2 4.1 7.3 0.2 2.1 2 0 0 2 2 2 0 B-box zinc finger NMD3 PF04981.8 EPA05399.1 - 0.12 11.5 2.6 0.15 11.1 1.8 1.2 1 1 0 1 1 1 0 NMD3 family zf-UBP PF02148.14 EPA05399.1 - 0.13 12.4 3.1 0.2 11.8 2.2 1.3 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein PHD PF00628.24 EPA05399.1 - 0.21 11.2 6.4 5.2 6.8 4.5 2.1 1 1 0 1 1 1 0 PHD-finger RNA_POL_M_15KD PF02150.11 EPA05399.1 - 0.38 10.4 5.4 0.98 9.1 3.5 1.8 1 1 1 2 2 2 0 RNA polymerases M/15 Kd subunit PHD_2 PF13831.1 EPA05399.1 - 0.4 10.0 5.8 1.7 8.0 1.1 2.2 2 0 0 2 2 2 0 PHD-finger Tnp_zf-ribbon_2 PF13842.1 EPA05399.1 - 0.7 10.3 4.0 5.3 7.5 2.8 2.0 1 1 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon Prim_Zn_Ribbon PF08273.7 EPA05399.1 - 0.85 9.7 4.3 17 5.5 3.3 2.0 1 1 1 2 2 2 0 Zinc-binding domain of primase-helicase zf-RanBP PF00641.13 EPA05399.1 - 3.5 6.7 7.0 0.32 10.1 0.4 2.0 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Fer4 PF00037.22 EPA05400.1 - 4.1e-08 32.5 16.0 0.00013 21.3 2.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.1 EPA05400.1 - 1e-06 28.8 5.1 2.2e-06 27.8 3.6 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.2 EPA05400.1 - 2.7e-06 27.6 5.1 5.7e-06 26.6 3.5 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 EPA05400.1 - 3e-06 26.9 5.2 6.2e-06 25.9 3.6 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.1 EPA05400.1 - 6.2e-05 22.7 3.3 9.6e-05 22.1 2.3 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.2 EPA05400.1 - 0.0002 21.0 13.1 0.0034 17.1 1.1 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.1 EPA05400.1 - 0.0017 18.3 4.1 0.013 15.5 3.5 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_18 PF13746.1 EPA05400.1 - 0.0029 18.0 3.6 0.59 10.6 0.4 2.6 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.1 EPA05400.1 - 0.003 17.8 0.4 2.9 8.3 0.0 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.2 EPA05400.1 - 0.0073 16.1 11.0 0.074 13.0 0.7 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.2 EPA05400.1 - 0.043 14.1 5.0 3.6 8.1 0.7 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_3 PF12798.2 EPA05400.1 - 0.11 13.1 15.1 0.21 12.2 1.1 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_13 PF13370.1 EPA05400.1 - 0.39 11.1 8.1 0.61 10.5 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_15 PF13459.1 EPA05400.1 - 0.47 11.0 10.7 0.43 11.1 0.4 3.1 3 0 0 3 3 3 0 4Fe-4S single cluster domain Fer4_16 PF13484.1 EPA05400.1 - 0.57 10.9 7.5 5 7.9 1.5 2.5 1 1 1 2 2 2 0 4Fe-4S double cluster binding domain HSBP1 PF06825.7 EPA05401.1 - 1.7e-06 27.4 4.2 0.17 11.5 0.0 5.4 3 1 2 5 5 5 2 Heat shock factor binding protein 1 NPV_P10 PF05531.7 EPA05401.1 - 2.1e-05 24.6 39.9 0.25 11.6 0.7 6.5 1 1 2 5 5 5 3 Nucleopolyhedrovirus P10 protein PilJ PF13675.1 EPA05401.1 - 0.00078 19.7 3.0 0.18 12.0 0.3 4.2 1 1 3 5 5 5 1 Type IV pili methyl-accepting chemotaxis transducer N-term DUF1664 PF07889.7 EPA05401.1 - 0.00081 19.1 39.0 0.0025 17.6 1.2 5.7 1 1 4 5 5 5 2 Protein of unknown function (DUF1664) AAA_13 PF13166.1 EPA05401.1 - 0.0026 16.3 13.3 0.0026 16.3 9.2 2.9 1 1 2 3 3 3 3 AAA domain Fib_alpha PF08702.5 EPA05401.1 - 0.0069 16.5 2.3 0.0069 16.5 1.6 4.9 1 1 4 5 5 5 1 Fibrinogen alpha/beta chain family MCPsignal PF00015.16 EPA05401.1 - 0.019 14.5 41.3 0.19 11.2 7.0 4.1 1 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain COMP PF11598.3 EPA05401.1 - 0.031 14.3 0.1 1.1 9.4 0.0 3.3 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein Syntaxin_2 PF14523.1 EPA05401.1 - 0.041 13.8 43.5 0.028 14.4 2.1 5.9 1 1 4 5 5 5 0 Syntaxin-like protein IncA PF04156.9 EPA05401.1 - 0.045 13.3 24.3 0.083 12.4 3.9 3.7 1 1 2 3 3 3 0 IncA protein MitMem_reg PF13012.1 EPA05401.1 - 0.082 12.9 30.9 0.4 10.7 1.1 5.3 1 1 3 4 4 4 0 Maintenance of mitochondrial structure and function Serine_rich PF08824.5 EPA05401.1 - 0.083 12.6 15.2 5.4 6.7 1.1 4.4 1 1 2 3 3 3 0 Serine rich protein interaction domain DUF948 PF06103.6 EPA05401.1 - 0.13 12.1 37.6 1.4 8.8 1.8 6.6 1 1 5 6 6 6 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.6 EPA05401.1 - 0.16 11.8 30.6 0.39 10.6 0.3 7.5 4 2 2 6 6 6 0 Flagella accessory protein C (FlaC) DASH_Dad4 PF08650.5 EPA05401.1 - 0.17 11.7 10.6 2.4 8.1 0.2 4.0 3 1 0 3 3 3 0 DASH complex subunit Dad4 Cauli_AT PF03233.8 EPA05401.1 - 0.21 11.2 39.8 0.33 10.6 0.3 5.2 2 2 3 5 5 5 0 Aphid transmission protein Laminin_II PF06009.7 EPA05401.1 - 0.36 10.5 43.2 0.018 14.8 7.0 4.9 1 1 2 4 4 4 0 Laminin Domain II BLOC1_2 PF10046.4 EPA05401.1 - 0.62 10.2 47.3 0.16 12.1 1.3 6.9 1 1 4 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Reo_sigmaC PF04582.7 EPA05401.1 - 0.65 9.1 32.4 0.4 9.8 0.9 4.2 1 1 3 4 4 4 0 Reovirus sigma C capsid protein DUF869 PF05911.6 EPA05401.1 - 0.94 7.6 43.0 1.8 6.6 28.6 1.9 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) CENP-F_leu_zip PF10473.4 EPA05401.1 - 1.1 9.1 36.8 0.55 10.0 7.1 4.2 1 1 3 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DASH_Dam1 PF08653.5 EPA05401.1 - 3.6 7.4 10.1 1.2e+02 2.5 0.1 5.7 5 1 1 6 6 6 0 DASH complex subunit Dam1 Syntaxin PF00804.20 EPA05401.1 - 5.2 7.2 49.1 1 9.5 3.7 6.1 2 1 2 4 4 4 0 Syntaxin ERCC4 PF02732.10 EPA05402.1 - 2.6e-24 85.6 0.0 4.5e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain HHH_5 PF14520.1 EPA05402.1 - 2.1e-07 31.0 0.0 5.1e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.18 EPA05402.1 - 3.9e-07 29.4 0.0 0.012 15.3 0.0 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_2 PF12826.2 EPA05402.1 - 1.3e-05 25.0 0.0 3.7e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_3 PF12836.2 EPA05402.1 - 0.00019 21.3 0.0 0.032 14.1 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_8 PF14716.1 EPA05402.1 - 0.009 16.1 0.2 1.1 9.4 0.0 2.4 1 1 1 2 2 2 2 Helix-hairpin-helix domain 5_3_exonuc PF01367.15 EPA05402.1 - 0.028 14.6 0.1 0.079 13.2 0.0 1.8 1 1 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold Pcc1 PF09341.5 EPA05404.1 - 3.4e-06 26.9 0.0 3.9e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 TrkA_C PF02080.16 EPA05404.1 - 0.014 15.0 0.0 0.015 14.8 0.0 1.1 1 0 0 1 1 1 0 TrkA-C domain tRNA_int_endo PF01974.12 EPA05405.1 - 1.6e-18 66.2 0.1 3.3e-18 65.2 0.0 1.5 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.9 EPA05405.1 - 7e-12 44.7 4.3 2.3e-11 43.0 0.5 2.3 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain DUF3135 PF11333.3 EPA05405.1 - 0.12 12.5 0.0 0.39 10.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) Spore_YabQ PF09578.5 EPA05406.1 - 0.0026 17.6 0.2 0.0048 16.8 0.2 1.4 1 0 0 1 1 1 1 Spore cortex protein YabQ (Spore_YabQ) Spore-coat_CotZ PF10612.4 EPA05407.1 - 0.075 12.9 0.0 0.076 12.8 0.0 1.0 1 0 0 1 1 1 0 Spore coat protein Z VWA_3 PF13768.1 EPA05407.1 - 0.087 12.5 0.0 0.094 12.4 0.0 1.0 1 0 0 1 1 1 0 von Willebrand factor type A domain Ribosomal_L16 PF00252.13 EPA05408.1 - 3.3e-22 78.6 0.4 4.1e-22 78.3 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e RNA_pol_A_bac PF01000.21 EPA05409.1 - 6.1e-25 87.5 0.0 1.2e-24 86.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 EPA05409.1 - 7e-13 47.4 0.0 8.4e-13 47.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF1492 PF07374.6 EPA05410.1 - 0.18 11.9 3.1 0.22 11.6 1.7 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1492) NAD_kinase PF01513.16 EPA05411.1 - 1.1e-36 126.1 1.7 1.3e-36 125.8 1.2 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.19 EPA05411.1 - 0.00074 18.9 0.3 0.0027 17.1 0.0 1.9 2 1 0 2 2 2 1 Diacylglycerol kinase catalytic domain CoA_binding_2 PF13380.1 EPA05411.1 - 0.0022 18.1 0.0 0.0051 16.9 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain RNase_PH PF01138.16 EPA05412.1 - 1.2e-20 74.1 0.0 2.2e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 EPA05412.1 - 1e-13 50.9 1.3 2.2e-13 49.9 0.0 2.2 3 0 0 3 3 3 1 3' exoribonuclease family, domain 2 SBBP PF06739.6 EPA05412.1 - 8.2 6.3 11.3 7 6.5 0.7 3.2 3 0 0 3 3 3 0 Beta-propeller repeat Na_H_Exchanger PF00999.16 EPA05413.1 - 2.3e-43 148.2 44.4 2.7e-43 147.9 30.8 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DZR PF12773.2 EPA05414.1 - 0.0025 17.5 2.8 0.0043 16.8 2.0 1.4 1 1 0 1 1 1 1 Double zinc ribbon DNA_ligase_ZBD PF03119.11 EPA05414.1 - 0.005 16.5 2.6 0.057 13.1 0.1 2.2 2 0 0 2 2 2 1 NAD-dependent DNA ligase C4 zinc finger domain zf-TFIIB PF13453.1 EPA05414.1 - 0.0091 15.1 1.9 1.1 8.4 0.1 2.2 2 0 0 2 2 2 2 Transcription factor zinc-finger zf-ribbon_3 PF13248.1 EPA05414.1 - 0.013 14.7 6.3 0.023 13.8 4.4 1.5 1 1 0 1 1 1 0 zinc-ribbon domain zinc-ribbons_6 PF07191.7 EPA05414.1 - 0.013 15.2 0.2 0.015 15.0 0.1 1.1 1 0 0 1 1 1 0 zinc-ribbons tRNA-synt_1g PF09334.6 EPA05414.1 - 0.013 14.1 0.1 0.013 14.1 0.1 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (M) Nudix_N_2 PF14803.1 EPA05414.1 - 0.019 14.6 3.6 0.2 11.4 0.1 2.3 2 0 0 2 2 2 0 Nudix N-terminal zf-C3HC4_3 PF13920.1 EPA05414.1 - 0.02 14.5 1.4 0.026 14.2 1.0 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) NOB1_Zn_bind PF08772.6 EPA05414.1 - 0.038 13.8 0.5 0.042 13.6 0.3 1.3 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like RecR PF02132.10 EPA05414.1 - 0.04 13.3 0.2 0.074 12.4 0.1 1.5 1 1 0 1 1 1 0 RecR protein Cript PF10235.4 EPA05414.1 - 0.04 14.2 0.5 0.046 14.0 0.3 1.1 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT Auto_anti-p27 PF06677.7 EPA05414.1 - 0.064 13.0 0.8 0.064 13.0 0.5 2.2 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-RING_6 PF14835.1 EPA05414.1 - 0.067 12.9 0.2 0.087 12.6 0.2 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein OrfB_Zn_ribbon PF07282.6 EPA05414.1 - 0.092 12.4 2.2 0.29 10.8 1.5 1.8 1 1 0 1 1 1 0 Putative transposase DNA-binding domain DUF3279 PF11682.3 EPA05414.1 - 0.15 11.6 2.0 0.16 11.5 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3279) Prok-RING_4 PF14447.1 EPA05414.1 - 0.17 11.4 3.3 0.63 9.6 0.1 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zinc_ribbon_2 PF13240.1 EPA05414.1 - 0.22 11.0 6.9 8.1 6.0 4.8 2.3 1 1 1 2 2 2 0 zinc-ribbon domain UPF0547 PF10571.4 EPA05414.1 - 0.27 10.9 4.0 0.99 9.1 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Rad50_zn_hook PF04423.9 EPA05414.1 - 0.3 10.5 4.9 0.35 10.3 0.2 2.1 1 1 1 2 2 2 0 Rad50 zinc hook motif Zn-ribbon_8 PF09723.5 EPA05414.1 - 0.33 10.9 4.6 1.3 9.0 0.2 2.1 1 1 1 2 2 2 0 Zinc ribbon domain zf-C4_Topoisom PF01396.14 EPA05414.1 - 0.43 10.1 4.5 0.72 9.4 0.7 2.1 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger DUF2752 PF10825.3 EPA05414.1 - 1.2 9.1 8.7 0.74 9.8 2.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2752) SBDS PF01172.13 EPA05415.1 - 3.1e-26 90.9 0.1 5.4e-26 90.2 0.1 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.5 EPA05415.1 - 1.4e-21 76.4 0.1 2.4e-21 75.7 0.1 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain Glyco_tranf_2_3 PF13641.1 EPA05417.1 - 2.5e-32 112.4 0.0 3.7e-32 111.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 EPA05417.1 - 7.3e-20 71.4 0.5 1.4e-19 70.5 0.4 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 EPA05417.1 - 4.2e-16 59.0 0.0 8e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 EPA05417.1 - 3e-12 46.1 0.1 5.4e-12 45.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Rhodanese PF00581.15 EPA05418.1 - 2.2e-20 73.0 0.0 2.6e-18 66.3 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain Aconitase_C PF00694.14 EPA05419.1 - 3.9e-21 75.5 0.4 1.4e-19 70.4 0.0 2.3 2 1 1 3 3 3 2 Aconitase C-terminal domain Aconitase_2_N PF06434.8 EPA05419.1 - 0.0019 17.6 0.2 0.012 15.0 0.1 2.0 1 1 0 1 1 1 1 Aconitate hydratase 2 N-terminus DUF2683 PF10884.3 EPA05419.1 - 0.1 12.5 0.6 0.25 11.2 0.4 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2683) Aconitase PF00330.15 EPA05420.1 - 3.9e-28 98.1 0.2 1e-24 86.8 0.1 2.0 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) RNase_PH PF01138.16 EPA05421.1 - 1.2e-34 119.4 0.0 1.6e-34 119.0 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 EPA05421.1 - 9.3e-13 47.9 0.1 2.2e-12 46.7 0.1 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 AIM24 PF01987.12 EPA05422.1 - 3.6e-54 183.4 0.1 4.1e-54 183.3 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 DisA_N PF02457.11 EPA05422.1 - 0.094 11.8 0.1 0.24 10.5 0.0 1.6 2 0 0 2 2 2 0 DisA bacterial checkpoint controller nucleotide-binding KH_1 PF00013.24 EPA05423.1 - 1.4e-11 43.8 0.3 3.4e-11 42.6 0.2 1.6 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 EPA05423.1 - 3.3e-05 23.4 0.1 8.8e-05 22.0 0.1 1.8 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 EPA05423.1 - 0.001 18.6 0.1 0.002 17.6 0.0 1.5 1 0 0 1 1 1 1 KH domain KH_4 PF13083.1 EPA05423.1 - 0.058 13.0 0.1 0.14 11.8 0.0 1.8 1 0 0 1 1 1 0 KH domain TAF PF02969.12 EPA05423.1 - 0.1 12.5 0.3 1.4 8.8 0.0 2.2 2 0 0 2 2 2 0 TATA box binding protein associated factor (TAF) Ribosomal_L13 PF00572.13 EPA05424.1 - 4e-26 91.5 0.0 5e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Rhodanese PF00581.15 EPA05425.1 - 1.6e-38 131.5 0.3 2.4e-22 79.4 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain Ribosomal_S9 PF00380.14 EPA05427.1 - 2.4e-35 121.3 0.2 2.8e-35 121.2 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Prefoldin_2 PF01920.15 EPA05428.1 - 2.2e-22 78.8 19.3 2.5e-22 78.6 13.4 1.0 1 0 0 1 1 1 1 Prefoldin subunit FixO PF02433.10 EPA05428.1 - 0.55 9.5 4.0 0.7 9.2 2.8 1.1 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO Sld5 PF05916.6 EPA05428.1 - 1.8 8.8 6.2 3.6 7.9 4.3 1.7 1 1 0 1 1 1 0 GINS complex protein Macoilin PF09726.4 EPA05428.1 - 2.7 6.1 10.5 3.2 5.9 7.3 1.0 1 0 0 1 1 1 0 Transmembrane protein DUF342 PF03961.8 EPA05428.1 - 3.5 5.9 10.9 5 5.4 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Nup88 PF10168.4 EPA05428.1 - 8.2 4.1 10.2 11 3.7 7.1 1.2 1 0 0 1 1 1 0 Nuclear pore component TP53IP5 PF15331.1 EPA05428.1 - 8.6 6.2 10.1 40 4.0 7.0 1.9 1 1 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Aconitase PF00330.15 EPA05429.1 - 3.6e-50 170.8 0.3 4.5e-50 170.4 0.2 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Ribosomal_L18e PF00828.14 EPA05431.1 - 4.3e-09 36.8 0.1 5.5e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 NTP_transferase PF00483.18 EPA05432.1 - 8.7e-18 64.5 0.1 1.1e-17 64.2 0.0 1.0 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 EPA05432.1 - 1.3e-11 44.8 0.0 1.4e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_3 PF02348.14 EPA05432.1 - 0.045 13.3 0.0 0.097 12.2 0.0 1.5 1 0 0 1 1 1 0 Cytidylyltransferase IspD PF01128.14 EPA05432.1 - 0.07 12.6 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase zf-C4pol PF14260.1 EPA05433.1 - 0.013 15.4 0.6 0.018 15.0 0.4 1.1 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta LIM PF00412.17 EPA05433.1 - 0.041 13.9 0.1 0.047 13.7 0.1 1.1 1 0 0 1 1 1 0 LIM domain eIF-5_eIF-2B PF01873.12 EPA05433.1 - 0.12 12.0 0.4 0.14 11.8 0.3 1.2 1 0 0 1 1 1 0 Domain found in IF2B/IF5 DUF4428 PF14471.1 EPA05433.1 - 0.12 12.1 1.2 0.16 11.7 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) Ribosomal_L37ae PF01780.14 EPA05434.1 - 2.5e-19 68.9 1.8 2.7e-19 68.8 1.3 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.2 EPA05434.1 - 0.00083 19.1 3.1 0.00083 19.1 2.1 1.8 2 0 0 2 2 2 1 Transposase zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 EPA05434.1 - 0.0038 16.8 2.6 0.0053 16.3 1.8 1.5 1 1 0 1 1 1 1 Putative transposase DNA-binding domain Zn-ribbon_8 PF09723.5 EPA05434.1 - 0.016 15.1 1.0 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 Zinc ribbon domain C1_1 PF00130.17 EPA05434.1 - 0.019 14.7 2.7 0.024 14.3 1.8 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.2 EPA05434.1 - 0.034 13.9 2.3 0.055 13.3 1.6 1.4 1 1 0 1 1 1 0 Double zinc ribbon Prim_Zn_Ribbon PF08273.7 EPA05434.1 - 0.042 13.9 1.3 0.061 13.4 0.9 1.3 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase GCC2_GCC3 PF07699.8 EPA05434.1 - 0.046 13.2 0.9 0.064 12.8 0.6 1.3 1 0 0 1 1 1 0 GCC2 and GCC3 A2L_zn_ribbon PF08792.5 EPA05434.1 - 0.069 12.6 2.9 1.3 8.6 0.1 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-ISL3 PF14690.1 EPA05434.1 - 0.076 13.0 0.8 0.56 10.2 0.1 2.3 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 TF_Zn_Ribbon PF08271.7 EPA05434.1 - 0.12 11.6 2.1 0.22 10.8 1.5 1.4 1 1 0 1 1 1 0 TFIIB zinc-binding Prok-RING_1 PF14446.1 EPA05434.1 - 0.16 11.7 1.1 0.3 10.8 0.8 1.5 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 zf-ribbon_3 PF13248.1 EPA05434.1 - 0.17 11.1 4.2 1.3 8.3 3.0 2.0 1 1 1 2 2 2 0 zinc-ribbon domain DNA_ligase_ZBD PF03119.11 EPA05434.1 - 0.29 10.8 1.8 0.51 10.0 1.2 1.4 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain UPF0547 PF10571.4 EPA05434.1 - 0.34 10.6 3.2 0.83 9.4 0.4 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 YdjO PF14169.1 EPA05434.1 - 0.41 10.1 2.4 5.1 6.6 0.1 2.1 1 1 1 2 2 2 0 Cold-inducible protein YdjO DUF1451 PF07295.6 EPA05434.1 - 0.44 10.3 3.0 0.45 10.2 0.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1451) DUF2082 PF09855.4 EPA05434.1 - 0.61 9.9 3.7 1.4 8.8 0.1 2.3 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-RanBP PF00641.13 EPA05434.1 - 4 6.6 6.3 1.5 7.9 0.6 2.1 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Aconitase PF00330.15 EPA05435.1 - 9.6e-167 555.1 0.1 1.1e-166 554.9 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Phage_int_SAM_3 PF14659.1 EPA05436.1 - 0.092 13.0 4.0 0.38 11.0 2.4 2.2 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Aconitase_C PF00694.14 EPA05438.1 - 8e-41 139.2 0.0 1.4e-40 138.3 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase_2_N PF06434.8 EPA05438.1 - 0.00018 20.9 0.1 0.0068 15.8 0.1 2.1 1 1 0 1 1 1 1 Aconitate hydratase 2 N-terminus SBP_bac_5 PF00496.17 EPA05439.1 - 1.8e-07 30.3 2.6 0.00038 19.4 0.0 3.1 3 0 0 3 3 3 3 Bacterial extracellular solute-binding proteins, family 5 Middle PBP PF01161.15 EPA05440.1 - 8e-38 129.5 0.1 9e-38 129.3 0.1 1.0 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Fcf1 PF04900.7 EPA05442.1 - 2.6e-11 43.4 0.0 3.2e-11 43.2 0.0 1.0 1 0 0 1 1 1 1 Fcf1 BRCT PF00533.21 EPA05442.1 - 0.0036 17.4 0.9 0.044 13.9 0.1 2.5 1 1 2 3 3 3 1 BRCA1 C Terminus (BRCT) domain DUF2482 PF10655.4 EPA05442.1 - 0.049 13.6 0.4 0.14 12.2 0.1 1.7 1 1 0 1 1 1 0 Hypothetical protein of unknown function (DUF2482) MreB_Mbl PF06723.8 EPA05442.1 - 0.1 11.1 0.1 0.12 10.9 0.1 1.1 1 0 0 1 1 1 0 MreB/Mbl protein PIN PF01850.16 EPA05442.1 - 0.13 12.6 0.0 0.16 12.2 0.0 1.3 1 1 0 1 1 1 0 PIN domain eIF2_C PF09173.6 EPA05443.1 - 2.2e-24 85.3 0.2 8.9e-24 83.3 0.0 2.0 2 0 0 2 2 2 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.22 EPA05443.1 - 2.5e-07 30.3 0.1 3.4e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 EPA05443.1 - 6.6e-06 26.1 0.7 2.8e-05 24.1 0.2 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Usp PF00582.21 EPA05444.1 - 3.5e-18 66.1 0.0 4.1e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family EST1_DNA_bind PF10373.4 EPA05446.1 - 0.0074 15.5 0.5 0.011 14.9 0.3 1.2 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain Response_reg PF00072.19 EPA05447.1 - 5e-14 52.2 0.1 6.6e-14 51.8 0.1 1.2 1 0 0 1 1 1 1 Response regulator receiver domain RNA_binding PF01877.12 EPA05447.1 - 0.015 15.2 0.0 0.12 12.3 0.0 2.0 1 1 1 2 2 2 0 RNA binding Cep57_MT_bd PF06657.8 EPA05447.1 - 0.045 13.7 0.2 0.045 13.7 0.1 1.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Suppressor_P21 PF11479.3 EPA05447.1 - 0.047 13.4 0.0 0.084 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA silencing suppressor P21 KaiC PF06745.8 EPA05448.1 - 2.2e-19 69.4 0.7 2.6e-19 69.2 0.5 1.0 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.1 EPA05448.1 - 3e-06 26.7 0.0 6.4e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 EPA05448.1 - 0.00014 21.6 0.5 0.0002 21.1 0.3 1.1 1 0 0 1 1 1 1 Archaeal ATPase Rad51 PF08423.6 EPA05448.1 - 0.00016 20.6 0.0 0.00025 20.0 0.0 1.4 1 0 0 1 1 1 1 Rad51 NACHT PF05729.7 EPA05448.1 - 0.00017 21.2 0.1 0.00091 18.9 0.1 1.9 1 1 0 1 1 1 1 NACHT domain PAXNEB PF05625.6 EPA05448.1 - 0.00033 19.6 2.8 0.17 10.6 0.0 2.1 2 0 0 2 2 2 2 PAXNEB protein DUF2075 PF09848.4 EPA05448.1 - 0.00071 18.6 0.1 0.00091 18.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 EPA05448.1 - 0.0015 18.6 0.0 0.0024 17.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF835 PF05763.7 EPA05448.1 - 0.0031 17.0 1.1 0.0051 16.3 0.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF835) AAA_14 PF13173.1 EPA05448.1 - 0.0035 17.2 2.0 0.046 13.6 1.4 2.2 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 EPA05448.1 - 0.0052 16.2 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.1 EPA05448.1 - 0.0077 16.5 0.4 0.047 14.0 0.3 2.1 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.17 EPA05448.1 - 0.031 13.1 0.7 0.048 12.4 0.5 1.3 1 1 0 1 1 1 0 NB-ARC domain AF2331-like PF14556.1 EPA05448.1 - 0.035 14.4 0.1 0.093 13.0 0.1 1.8 1 0 0 1 1 1 0 AF2331-like FtsK_SpoIIIE PF01580.13 EPA05448.1 - 0.055 12.9 0.0 0.15 11.4 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family RNA_helicase PF00910.17 EPA05448.1 - 0.071 13.2 0.3 0.17 12.0 0.0 1.8 2 0 0 2 2 2 0 RNA helicase Elong_Iki1 PF10483.4 EPA05448.1 - 0.073 12.4 1.7 0.12 11.7 1.2 1.4 1 1 0 1 1 1 0 Elongator subunit Iki1 NTPase_1 PF03266.10 EPA05448.1 - 0.075 12.7 1.3 0.84 9.3 0.9 2.1 1 1 0 1 1 1 0 NTPase AAA PF00004.24 EPA05448.1 - 0.094 12.9 1.0 0.19 11.9 0.7 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Response_reg PF00072.19 EPA05449.1 - 1.1e-24 86.5 0.1 1.3e-24 86.3 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain DUF603 PF04645.7 EPA05450.1 - 0.021 14.7 0.4 0.027 14.4 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF603 YfcL PF08891.6 EPA05450.1 - 0.041 13.8 0.1 0.056 13.4 0.1 1.3 1 1 0 1 1 1 0 YfcL protein EAP30 PF04157.11 EPA05450.1 - 0.052 12.6 0.0 0.059 12.5 0.0 1.0 1 0 0 1 1 1 0 EAP30/Vps36 family MCPsignal PF00015.16 EPA05451.1 - 4.2e-46 157.1 43.3 8.8e-44 149.5 19.7 2.4 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain PAS_9 PF13426.1 EPA05451.1 - 3.2e-13 49.9 0.0 1.1e-12 48.2 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 EPA05451.1 - 3.5e-10 39.6 0.3 2.3e-09 37.0 0.0 2.3 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.6 EPA05451.1 - 5.4e-07 29.6 0.1 1.7e-06 28.0 0.1 1.8 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.5 EPA05451.1 - 0.00041 20.3 0.0 0.0017 18.3 0.0 2.0 2 0 0 2 2 2 1 PAS fold Reo_sigmaC PF04582.7 EPA05451.1 - 0.033 13.3 26.2 0.1 11.7 4.9 2.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein APG17 PF04108.7 EPA05451.1 - 0.059 12.1 18.8 0.39 9.4 2.6 3.0 2 1 0 2 2 2 0 Autophagy protein Apg17 HisKA PF00512.20 EPA05451.1 - 0.18 11.8 5.4 10 6.2 0.1 3.6 3 1 0 3 3 3 0 His Kinase A (phospho-acceptor) domain Spc7 PF08317.6 EPA05451.1 - 0.46 9.1 28.5 0.058 12.0 6.8 3.1 1 1 3 4 4 4 0 Spc7 kinetochore protein WXG100 PF06013.7 EPA05451.1 - 0.61 10.1 13.2 7.7 6.6 0.0 4.9 3 2 1 5 5 5 0 Proteins of 100 residues with WXG HisKA_3 PF07730.8 EPA05451.1 - 0.68 10.3 6.1 32 4.9 0.1 4.3 3 1 0 3 3 3 0 Histidine kinase ADIP PF11559.3 EPA05451.1 - 1 9.2 17.4 1 9.2 2.8 2.7 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding COG5 PF10392.4 EPA05451.1 - 3.6 7.5 15.7 0.14 12.1 2.9 3.1 2 2 0 2 2 2 0 Golgi transport complex subunit 5 Laminin_II PF06009.7 EPA05451.1 - 5.3 6.7 32.7 0.2 11.4 1.9 4.1 2 2 1 3 3 3 0 Laminin Domain II H-kinase_dim PF02895.9 EPA05451.1 - 9.2 6.6 14.6 0.68 10.3 1.2 4.4 2 2 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain COG2 PF06148.6 EPA05451.1 - 9.2 6.1 22.5 12 5.7 1.0 4.7 2 2 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 HATPase_c PF02518.21 EPA05452.1 - 4.4e-20 71.4 0.0 1.2e-19 70.0 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EPA05452.1 - 9.3e-09 35.1 0.0 2.4e-08 33.8 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain TarH PF02203.10 EPA05452.1 - 0.64 9.8 6.8 0.6 9.9 0.4 2.7 3 0 0 3 3 3 0 Tar ligand binding domain homologue CheC PF04509.7 EPA05453.1 - 5.4e-13 48.4 0.0 1.6e-12 46.9 0.0 1.8 1 0 0 1 1 1 1 CheC-like family CheX PF13690.1 EPA05453.1 - 2.2e-07 30.6 0.0 4.1e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Chemotaxis phosphatase CheX HATPase_c PF02518.21 EPA05455.1 - 5e-19 68.0 0.2 1.2e-18 66.8 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EPA05455.1 - 1.9e-09 37.4 0.5 5.1e-08 32.8 0.0 2.7 2 1 1 3 3 3 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.1 EPA05455.1 - 2.9e-07 30.1 0.0 9.1e-07 28.5 0.0 1.9 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.1 EPA05455.1 - 0.0074 16.0 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.1 EPA05455.1 - 0.023 14.3 0.0 0.023 14.3 0.0 2.2 3 0 0 3 3 3 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1985 PF09331.6 EPA05456.1 - 0.077 12.8 0.1 0.091 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1985) CPSase_L_D3 PF02787.14 EPA05456.1 - 0.083 12.6 0.3 0.13 11.9 0.2 1.4 1 1 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Arch_flagellin PF01917.11 EPA05457.1 - 3.6e-06 26.7 8.1 2.4e-05 24.0 5.6 1.9 1 1 0 1 1 1 1 Archaebacterial flagellin DUF973 PF06157.6 EPA05457.1 - 0.0095 14.9 0.2 0.0095 14.9 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF973) Big_5 PF13205.1 EPA05457.1 - 0.18 12.4 2.0 0.32 11.6 1.4 1.6 1 1 0 1 1 1 0 Bacterial Ig-like domain DUF2393 PF09624.5 EPA05457.1 - 5.4 6.5 8.0 4.4 6.8 3.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2393) T2SE PF00437.15 EPA05458.1 - 2.3e-45 154.6 0.0 3.2e-45 154.1 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein Response_reg PF00072.19 EPA05459.1 - 3.6e-26 91.3 0.7 4.4e-26 91.0 0.5 1.0 1 0 0 1 1 1 1 Response regulator receiver domain Response_reg PF00072.19 EPA05460.1 - 1.3e-12 47.6 0.2 1.7e-12 47.3 0.2 1.1 1 0 0 1 1 1 1 Response regulator receiver domain DUF3267 PF11667.3 EPA05462.1 - 1.3 9.2 7.2 0.23 11.6 2.0 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF3267) DUF334 PF03904.8 EPA05462.1 - 3 7.1 4.7 5.8 6.1 0.8 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF334) zf-AN1 PF01428.11 EPA05463.1 - 0.0025 17.6 0.3 0.0028 17.4 0.2 1.1 1 0 0 1 1 1 1 AN1-like Zinc finger zf-C2H2 PF00096.21 EPA05463.1 - 0.0079 16.4 0.7 0.013 15.8 0.5 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_2 PF12756.2 EPA05463.1 - 0.021 14.9 0.7 0.021 14.9 0.5 1.0 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.10 EPA05463.1 - 0.031 14.0 0.4 0.034 13.8 0.3 1.1 1 0 0 1 1 1 0 BED zinc finger zf-H2C2_2 PF13465.1 EPA05463.1 - 0.39 11.0 1.5 9.5 6.7 0.0 2.2 2 0 0 2 2 2 0 Zinc-finger double domain NHL PF01436.16 EPA05464.1 - 3.3e-15 55.1 3.4 0.14 12.1 0.0 7.2 6 1 0 6 6 6 4 NHL repeat Lactonase PF10282.4 EPA05464.1 - 2.2e-08 33.5 2.1 0.04 12.9 0.0 4.5 1 1 3 4 4 4 3 Lactonase, 7-bladed beta-propeller Cytochrom_D1 PF02239.11 EPA05464.1 - 2.5e-05 22.7 4.3 0.018 13.3 0.3 2.5 1 1 0 2 2 2 2 Cytochrome D1 heme domain Arylesterase PF01731.15 EPA05464.1 - 0.00027 20.8 14.3 3.5 7.6 0.1 5.9 4 1 2 6 6 6 3 Arylesterase RhgB_N PF09284.5 EPA05464.1 - 0.016 14.5 2.0 1.4 8.2 0.0 2.4 2 0 0 2 2 2 0 Rhamnogalacturonase B, N-terminal GDPD PF03009.12 EPA05464.1 - 0.037 13.5 0.0 0.13 11.7 0.0 1.7 1 1 1 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family CheW PF01584.14 EPA05465.1 - 5.2e-33 113.4 0.1 6.2e-33 113.1 0.1 1.1 1 0 0 1 1 1 1 CheW-like domain IZUMO PF15005.1 EPA05465.1 - 0.1 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Izumo sperm-egg fusion Peptidase_C31 PF05410.8 EPA05466.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Porcine arterivirus-type cysteine proteinase alpha CheD PF03975.8 EPA05468.1 - 7.3e-14 51.5 0.0 1.1e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 CheD chemotactic sensory transduction Cu-oxidase_4 PF02578.10 EPA05468.1 - 0.086 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Multi-copper polyphenol oxidoreductase laccase Response_reg PF00072.19 EPA05469.1 - 9e-23 80.4 0.1 1.1e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain THF_DHG_CYH PF00763.18 EPA05469.1 - 0.079 12.9 0.1 0.16 12.0 0.1 1.5 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain CheB_methylest PF01339.12 EPA05470.1 - 2e-63 213.1 0.0 4.1e-63 212.0 0.0 1.5 1 0 0 1 1 1 1 CheB methylesterase Response_reg PF00072.19 EPA05470.1 - 1.9e-20 72.9 0.9 4.3e-20 71.7 0.7 1.6 1 0 0 1 1 1 1 Response regulator receiver domain DUF3798 PF12683.2 EPA05470.1 - 0.048 12.7 0.3 0.076 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3798) AMIN PF11741.3 EPA05470.1 - 0.15 12.0 1.7 0.67 9.9 0.1 2.5 2 1 1 3 3 3 0 AMIN domain DUF3362 PF11842.3 EPA05471.1 - 0.007 16.2 0.1 0.0078 16.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3362) Pex24p PF06398.6 EPA05471.1 - 0.019 13.7 0.1 0.022 13.5 0.1 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin RNA_pol_Rpc82 PF05645.8 EPA05471.1 - 0.024 14.1 3.6 0.03 13.8 2.5 1.1 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 PRP1_N PF06424.7 EPA05471.1 - 0.024 14.9 4.2 0.036 14.3 2.9 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal ATP-synt_8 PF00895.15 EPA05471.1 - 0.029 14.5 1.4 0.04 14.1 0.1 2.0 2 1 0 2 2 2 0 ATP synthase protein 8 DUF4179 PF13786.1 EPA05471.1 - 0.046 13.9 0.3 0.046 13.9 0.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) DUF1514 PF07438.6 EPA05471.1 - 0.058 13.3 1.3 0.078 12.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1514) Phage_Gp23 PF10669.4 EPA05471.1 - 0.081 13.0 2.2 0.11 12.6 1.5 1.2 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Nucleoside_tran PF01733.13 EPA05471.1 - 0.16 11.1 0.2 0.17 10.9 0.2 1.1 1 0 0 1 1 1 0 Nucleoside transporter DUF2149 PF09919.4 EPA05471.1 - 0.18 11.9 0.8 0.55 10.3 0.1 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2149) DUF1980 PF09323.5 EPA05471.1 - 0.26 11.0 2.4 0.37 10.4 1.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) Secretin_N_2 PF07655.8 EPA05471.1 - 1.5 9.2 5.6 2 8.8 3.9 1.2 1 0 0 1 1 1 0 Secretin N-terminal domain CheW PF01584.14 EPA05472.1 - 1e-19 70.3 0.1 1.8e-19 69.6 0.1 1.4 1 0 0 1 1 1 1 CheW-like domain HATPase_c PF02518.21 EPA05472.1 - 8.7e-19 67.2 4.1 1.7e-18 66.3 1.4 2.3 1 1 1 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Hpt PF01627.18 EPA05472.1 - 5.2e-15 55.2 0.0 9.9e-15 54.3 0.0 1.5 1 0 0 1 1 1 1 Hpt domain H-kinase_dim PF02895.9 EPA05472.1 - 2.1e-10 40.7 0.7 6.5e-10 39.2 0.5 1.9 1 0 0 1 1 1 1 Signal transducing histidine kinase, homodimeric domain HATPase_c_3 PF13589.1 EPA05472.1 - 0.0009 18.9 0.5 0.0024 17.5 0.3 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 EPA05472.1 - 0.072 12.8 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain CheR PF01739.13 EPA05473.1 - 1.1e-51 174.9 0.1 1.3e-51 174.7 0.1 1.1 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain CheR_N PF03705.10 EPA05473.1 - 1e-09 37.6 1.0 2.7e-09 36.2 0.0 2.2 2 0 0 2 2 2 1 CheR methyltransferase, all-alpha domain Methyltransf_31 PF13847.1 EPA05473.1 - 9.5e-08 31.7 4.0 1.2e-05 24.9 1.5 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA05473.1 - 2.6e-07 31.0 0.2 1.6e-05 25.3 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA05473.1 - 2.6e-05 24.6 0.1 0.00038 20.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA05473.1 - 4.8e-05 23.1 0.0 7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EPA05473.1 - 5.3e-05 23.5 0.0 0.00011 22.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA05473.1 - 0.00036 21.0 0.0 0.00073 20.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DUF4268 PF14088.1 EPA05473.1 - 0.012 15.2 1.0 0.028 14.0 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4268) NodS PF05401.6 EPA05473.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) FUR PF01475.14 EPA05474.1 - 0.062 13.2 0.7 0.15 11.9 0.0 2.0 2 1 0 2 2 2 0 Ferric uptake regulator family FKBP_N PF01346.13 EPA05474.1 - 0.086 12.8 3.6 0.06 13.4 0.9 1.7 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Pyr_redox_2 PF07992.9 EPA05475.1 - 6.4e-19 68.6 0.0 1.1e-18 67.8 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EPA05475.1 - 1.6e-09 38.0 0.4 3.9e-07 30.3 0.2 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EPA05475.1 - 0.063 13.0 0.0 3.4 7.4 0.0 3.1 4 0 0 4 4 4 0 FAD-NAD(P)-binding GATase PF00117.23 EPA05476.1 - 4.2e-22 78.5 0.0 4.6e-22 78.4 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EPA05476.1 - 0.00059 19.3 0.1 0.0045 16.4 0.1 2.0 1 1 0 1 1 1 1 Peptidase C26 Sod_Fe_C PF02777.13 EPA05478.1 - 1.5e-43 146.9 0.3 2.8e-43 146.0 0.2 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 EPA05478.1 - 2.2e-29 101.5 1.3 4e-29 100.7 0.9 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain SRP54 PF00448.17 EPA05479.1 - 2.4e-70 236.0 0.6 3.3e-70 235.5 0.4 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.14 EPA05479.1 - 1.5e-09 37.8 6.3 4.4e-09 36.3 4.4 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_30 PF13604.1 EPA05479.1 - 7.3e-07 28.9 0.1 1.4e-06 28.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EPA05479.1 - 7.9e-06 26.0 0.2 2e-05 24.7 0.1 1.7 1 1 1 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EPA05479.1 - 0.00013 21.1 0.2 0.00021 20.4 0.1 1.3 1 0 0 1 1 1 1 Zeta toxin CbiA PF01656.18 EPA05479.1 - 0.00017 21.0 0.2 0.00036 19.9 0.1 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain cobW PF02492.14 EPA05479.1 - 0.00019 20.9 0.5 0.00062 19.2 0.4 1.8 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 EPA05479.1 - 0.00056 19.8 0.0 0.0009 19.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EPA05479.1 - 0.00057 20.0 0.1 0.0018 18.4 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MobB PF03205.9 EPA05479.1 - 0.00061 19.5 0.2 0.0056 16.4 0.0 2.3 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 EPA05479.1 - 0.0017 18.0 0.1 0.0032 17.1 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 EPA05479.1 - 0.0024 17.8 0.0 0.0041 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain APS_kinase PF01583.15 EPA05479.1 - 0.006 16.2 0.1 0.024 14.3 0.0 2.0 2 0 0 2 2 2 1 Adenylylsulphate kinase PIF1 PF05970.9 EPA05479.1 - 0.0074 15.2 0.1 0.012 14.6 0.1 1.2 1 0 0 1 1 1 1 PIF1-like helicase DAP3 PF10236.4 EPA05479.1 - 0.0095 14.8 0.0 0.015 14.2 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 Thymidylate_kin PF02223.12 EPA05479.1 - 0.011 15.1 0.0 0.032 13.5 0.0 1.9 2 0 0 2 2 2 0 Thymidylate kinase TK PF00265.13 EPA05479.1 - 0.012 15.1 0.1 0.022 14.2 0.1 1.4 1 0 0 1 1 1 0 Thymidine kinase DUF2075 PF09848.4 EPA05479.1 - 0.013 14.4 0.1 0.021 13.8 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ArgK PF03308.11 EPA05479.1 - 0.015 14.1 0.1 0.06 12.1 0.1 1.9 1 1 0 1 1 1 0 ArgK protein ABC_tran PF00005.22 EPA05479.1 - 0.016 15.5 0.1 0.035 14.3 0.0 1.7 1 1 0 1 1 1 0 ABC transporter KTI12 PF08433.5 EPA05479.1 - 0.018 14.2 0.1 0.041 13.0 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 PEPCK_ATP PF01293.15 EPA05479.1 - 0.02 13.4 0.1 0.034 12.6 0.1 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase B12-binding PF02310.14 EPA05479.1 - 0.027 14.3 0.4 0.079 12.8 0.3 1.7 1 1 0 1 1 1 0 B12 binding domain TPP_enzyme_M PF00205.17 EPA05479.1 - 0.03 14.0 0.1 0.32 10.7 0.1 2.5 3 0 0 3 3 3 0 Thiamine pyrophosphate enzyme, central domain AAA_14 PF13173.1 EPA05479.1 - 0.034 14.0 0.3 0.13 12.1 0.0 2.2 2 2 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 EPA05479.1 - 0.034 13.8 0.5 1 9.0 0.3 2.4 1 1 0 1 1 1 0 NTPase AAA_5 PF07728.9 EPA05479.1 - 0.045 13.4 0.0 0.083 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Arch_ATPase PF01637.13 EPA05479.1 - 0.054 13.1 1.3 0.11 12.1 0.1 2.1 2 1 1 3 3 2 0 Archaeal ATPase PPK2 PF03976.9 EPA05479.1 - 0.091 12.0 0.0 0.18 11.0 0.0 1.5 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) AAA_28 PF13521.1 EPA05479.1 - 0.096 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Helicase_RecD PF05127.9 EPA05479.1 - 0.13 11.8 0.5 0.39 10.3 0.3 1.8 1 1 0 1 1 1 0 Helicase Prefoldin PF02996.12 EPA05480.1 - 3.6e-16 58.9 8.1 1.7e-15 56.7 5.6 1.9 1 1 0 1 1 1 1 Prefoldin subunit LMP PF04778.7 EPA05480.1 - 0.00068 19.4 0.1 0.0013 18.4 0.1 1.4 1 0 0 1 1 1 1 LMP repeated region TMF_TATA_bd PF12325.3 EPA05480.1 - 0.011 15.4 6.7 0.069 12.8 0.5 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding NIT PF08376.5 EPA05480.1 - 0.023 14.2 4.5 0.095 12.2 0.4 2.0 1 1 1 2 2 2 0 Nitrate and nitrite sensing DUF2408 PF10303.4 EPA05480.1 - 0.024 14.7 0.6 0.04 14.0 0.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) SF-assemblin PF06705.6 EPA05480.1 - 0.029 13.5 1.9 0.5 9.4 0.5 2.1 1 1 1 2 2 2 0 SF-assemblin/beta giardin Reo_sigmaC PF04582.7 EPA05480.1 - 0.22 10.6 2.3 0.31 10.1 0.3 1.8 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Prefoldin_2 PF01920.15 EPA05480.1 - 0.4 10.4 10.5 0.094 12.4 1.0 2.3 2 1 0 2 2 2 0 Prefoldin subunit Ax_dynein_light PF10211.4 EPA05480.1 - 0.96 9.2 6.8 4.9 6.9 0.2 2.0 2 0 0 2 2 2 0 Axonemal dynein light chain DUF948 PF06103.6 EPA05480.1 - 1 9.2 4.3 8.6 6.2 0.3 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) ALIX_LYPXL_bnd PF13949.1 EPA05480.1 - 1.1 8.0 6.5 1.2 7.9 0.7 2.1 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV CENP-F_leu_zip PF10473.4 EPA05480.1 - 5.6 6.8 10.5 3.6 7.4 2.0 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlxA PF14282.1 EPA05480.1 - 8.4 6.3 10.9 7.8 6.5 1.1 2.4 2 0 0 2 2 2 0 FlxA-like protein FadA PF09403.5 EPA05480.1 - 9.7 6.2 8.4 8.1 6.4 0.3 2.5 2 1 0 2 2 2 0 Adhesion protein FadA Copper-bind PF00127.15 EPA05482.1 - 8.1e-15 54.8 0.4 1.8e-07 31.2 0.0 2.6 2 1 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cu-oxidase_3 PF07732.10 EPA05482.1 - 2.1e-11 43.6 0.6 1.5e-05 24.6 0.0 3.1 2 2 0 2 2 2 2 Multicopper oxidase Cupredoxin_1 PF13473.1 EPA05482.1 - 4.2e-09 36.2 0.0 0.00037 20.3 0.0 2.6 2 0 0 2 2 2 2 Cupredoxin-like domain Cu_bind_like PF02298.12 EPA05482.1 - 1.8e-08 34.0 0.0 0.0047 16.6 0.0 2.9 2 1 0 2 2 2 2 Plastocyanin-like domain SoxE PF06525.6 EPA05482.1 - 7.6e-08 31.8 0.8 0.011 15.0 0.0 2.6 2 1 0 2 2 2 2 Sulfocyanin (SoxE) Cu-oxidase_2 PF07731.9 EPA05482.1 - 1.3e-05 24.7 0.0 0.016 14.7 0.0 2.6 2 1 0 2 2 2 2 Multicopper oxidase COX2 PF00116.15 EPA05482.1 - 0.0015 18.3 0.0 0.88 9.4 0.0 2.8 3 0 0 3 3 3 2 Cytochrome C oxidase subunit II, periplasmic domain CHU_C PF13585.1 EPA05482.1 - 0.011 15.6 0.1 2.9 7.8 0.0 2.5 2 0 0 2 2 2 0 C-terminal domain of CHU protein family PGBA_N PF15436.1 EPA05482.1 - 0.011 15.0 0.0 1.7 7.8 0.0 2.1 2 0 0 2 2 2 0 Plasminogen-binding protein pgbA N-terminal PPC PF04151.10 EPA05482.1 - 0.17 12.8 4.6 0.23 12.4 0.2 2.6 2 1 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain DUF2566 PF10753.4 EPA05483.1 - 0.053 13.4 0.2 0.088 12.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2566) HisKA PF00512.20 EPA05484.1 - 0.012 15.5 0.1 0.014 15.4 0.0 1.1 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain NPV_P10 PF05531.7 EPA05484.1 - 0.083 13.1 1.2 0.098 12.9 0.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Wbp11 PF09429.5 EPA05484.1 - 0.14 12.1 0.2 0.16 11.9 0.2 1.2 1 0 0 1 1 1 0 WW domain binding protein 11 AA_kinase PF00696.23 EPA05486.1 - 1e-25 90.6 0.4 2.5e-25 89.4 0.3 1.7 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.20 EPA05486.1 - 0.12 11.8 0.5 0.33 10.4 0.3 1.7 1 0 0 1 1 1 0 ACT domain Pyridox_oxidase PF01243.15 EPA05487.1 - 1.6e-17 63.2 0.0 4e-17 62.0 0.0 1.6 1 1 1 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 EPA05487.1 - 1.2e-10 41.3 0.0 1.8e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase YmdB PF13277.1 EPA05487.1 - 0.0024 16.9 0.0 0.0028 16.7 0.0 1.2 1 0 0 1 1 1 1 YmdB-like protein DUF2373 PF10180.4 EPA05487.1 - 0.088 12.3 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) Aminotran_4 PF01063.14 EPA05488.1 - 2.9e-44 151.2 0.0 3.3e-44 151.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class IV COX15-CtaA PF02628.10 EPA05489.1 - 5e-27 94.5 9.3 6.2e-27 94.2 6.4 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein DUF2614 PF11023.3 EPA05489.1 - 4.6 7.0 7.1 2.4 7.9 1.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2614) YesK PF14150.1 EPA05489.1 - 7.2 6.7 12.9 0.49 10.5 0.5 2.8 2 1 0 2 2 2 0 YesK-like protein COX1 PF00115.15 EPA05490.1 - 9e-143 476.1 60.3 1.2e-142 475.7 41.8 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DUF438 PF04282.8 EPA05491.1 - 0.069 12.9 0.0 0.094 12.5 0.0 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF438) adh_short_C2 PF13561.1 EPA05492.1 - 2.1e-09 37.5 0.0 2.6e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EPA05492.1 - 9.5e-05 22.3 0.1 0.055 13.3 0.0 2.3 1 1 1 2 2 2 2 short chain dehydrogenase RmlD_sub_bind PF04321.12 EPA05492.1 - 0.021 13.7 0.0 0.036 12.9 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain AHSA1 PF08327.6 EPA05493.1 - 3.6e-08 33.5 0.0 5.4e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.4 EPA05493.1 - 9.4e-08 32.3 0.0 1.2e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 EPA05493.1 - 8.8e-07 28.9 0.0 1.3e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport EMP70 PF02990.11 EPA05494.1 - 0.12 10.8 4.5 0.18 10.2 3.1 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 DUF2104 PF09877.4 EPA05494.1 - 0.77 9.7 5.4 5.7 6.9 0.2 3.1 3 1 0 3 3 3 0 Predicted membrane protein (DUF2104) CbiA PF01656.18 EPA05495.1 - 7.8e-26 90.6 0.1 8.6e-26 90.5 0.1 1.0 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.1 EPA05495.1 - 1.3e-15 57.4 0.0 4.3e-15 55.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain MobB PF03205.9 EPA05495.1 - 9.9e-06 25.3 0.1 0.0056 16.3 0.0 2.3 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.17 EPA05495.1 - 0.00021 20.8 0.4 0.26 10.7 0.0 2.2 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_23 PF13476.1 EPA05495.1 - 0.0025 18.1 0.4 0.0031 17.8 0.3 1.2 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.10 EPA05495.1 - 0.0074 16.0 0.0 0.053 13.2 0.0 2.0 2 0 0 2 2 2 1 NTPase AAA_17 PF13207.1 EPA05495.1 - 0.01 16.6 0.0 0.055 14.3 0.0 2.1 1 1 0 1 1 1 0 AAA domain Miro PF08477.8 EPA05495.1 - 0.016 15.6 0.1 4.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Miro-like protein AAA_29 PF13555.1 EPA05495.1 - 0.019 14.4 0.3 0.046 13.2 0.1 1.8 1 1 1 2 2 2 0 P-loop containing region of AAA domain Act-Frag_cataly PF09192.5 EPA05495.1 - 0.021 13.8 0.3 0.031 13.2 0.2 1.2 1 0 0 1 1 1 0 Actin-fragmin kinase, catalytic APS_kinase PF01583.15 EPA05495.1 - 0.029 14.0 0.0 0.041 13.5 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF1792 PF08759.6 EPA05495.1 - 0.033 13.7 0.1 0.047 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1792) AAA_16 PF13191.1 EPA05495.1 - 0.037 14.0 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain PRK PF00485.13 EPA05495.1 - 0.041 13.4 0.2 0.074 12.5 0.1 1.5 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family SelA PF03841.8 EPA05495.1 - 0.053 12.2 0.1 0.069 11.8 0.1 1.1 1 0 0 1 1 1 0 L-seryl-tRNA selenium transferase AAA_31 PF13614.1 EPA05495.1 - 0.055 13.3 0.2 0.26 11.1 0.1 2.1 2 1 0 2 2 2 0 AAA domain cobW PF02492.14 EPA05495.1 - 0.086 12.2 0.1 0.76 9.2 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain VirC1 PF07015.6 EPA05495.1 - 0.12 11.4 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 VirC1 protein DUF1533 PF07550.6 EPA05495.1 - 0.4 10.7 4.1 0.13 12.3 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1533) tRNA-synt_2c PF01411.14 EPA05496.1 - 0.07 11.4 0.1 0.083 11.1 0.1 1.0 1 0 0 1 1 1 0 tRNA synthetases class II (A) DUF2653 PF10850.3 EPA05496.1 - 0.089 13.0 0.2 0.099 12.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2653) Glyco_trans_1_3 PF13528.1 EPA05498.1 - 3.8e-16 59.1 0.0 5.5e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.11 EPA05498.1 - 6e-12 45.5 0.3 6.3e-11 42.2 0.0 2.5 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain Nit_Regul_Hom PF10126.4 EPA05498.1 - 0.39 10.4 3.4 0.26 11.0 0.6 2.0 2 0 0 2 2 2 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII Cytokin_check_N PF10407.4 EPA05500.1 - 0.057 13.0 0.4 0.072 12.7 0.3 1.3 1 0 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus Cas_Cas6 PF01881.11 EPA05500.1 - 0.11 12.7 1.0 0.12 12.6 0.7 1.0 1 0 0 1 1 1 0 CRISPR associated protein Cas6 IF-2B PF01008.12 EPA05501.1 - 1.8e-86 289.6 1.3 2.5e-86 289.1 0.5 1.4 1 1 1 2 2 2 1 Initiation factor 2 subunit family RRM_1 PF00076.17 EPA05501.1 - 0.082 12.5 0.0 0.49 10.0 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UbiA PF01040.13 EPA05503.1 - 9.7e-25 87.2 20.8 1.3e-24 86.8 14.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Response_reg PF00072.19 EPA05504.1 - 3.9e-22 78.3 0.6 4.5e-22 78.1 0.4 1.0 1 0 0 1 1 1 1 Response regulator receiver domain YcgR PF07317.7 EPA05504.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.6 1 1 0 1 1 1 0 Flagellar regulator YcgR Ribosomal_S27e PF01667.12 EPA05505.1 - 5.4e-18 64.2 1.1 6.4e-18 64.0 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S27 Zn_Tnp_IS91 PF14319.1 EPA05505.1 - 0.0022 17.4 0.9 0.0025 17.3 0.6 1.1 1 0 0 1 1 1 1 Transposase zinc-binding domain zinc_ribbon_6 PF14599.1 EPA05505.1 - 0.0063 16.2 2.6 0.034 13.9 1.8 1.9 1 1 0 1 1 1 1 Zinc-ribbon zf-ribbon_3 PF13248.1 EPA05505.1 - 0.0083 15.2 3.3 0.021 14.0 2.3 1.7 1 1 1 2 2 2 2 zinc-ribbon domain TF_Zn_Ribbon PF08271.7 EPA05505.1 - 0.011 15.0 0.7 0.015 14.6 0.5 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding DUF2318 PF10080.4 EPA05505.1 - 0.017 14.9 0.5 0.02 14.6 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) C1_1 PF00130.17 EPA05505.1 - 0.02 14.5 0.6 0.028 14.1 0.4 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-BED PF02892.10 EPA05505.1 - 0.023 14.4 2.7 1 9.1 0.1 2.2 1 1 1 2 2 2 0 BED zinc finger DZR PF12773.2 EPA05505.1 - 0.029 14.1 2.2 0.067 13.0 1.5 1.6 1 1 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.5 EPA05505.1 - 0.032 14.1 0.8 0.055 13.4 0.5 1.4 1 1 0 1 1 1 0 Zinc ribbon domain YhfH PF14149.1 EPA05505.1 - 0.038 13.7 1.6 1.7 8.5 0.0 2.2 2 0 0 2 2 2 0 YhfH-like protein FYVE PF01363.16 EPA05505.1 - 0.048 13.5 0.2 0.059 13.2 0.2 1.2 1 0 0 1 1 1 0 FYVE zinc finger zf-dskA_traR PF01258.12 EPA05505.1 - 0.053 13.2 0.3 6.6 6.5 0.1 2.2 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger TerY-C PF15616.1 EPA05505.1 - 0.061 13.2 0.7 0.065 13.1 0.5 1.1 1 0 0 1 1 1 0 TerY-C metal binding domain RRN7 PF11781.3 EPA05505.1 - 0.064 12.7 0.7 5.9 6.4 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 HypA PF01155.14 EPA05505.1 - 0.065 12.9 0.5 0.071 12.7 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Prok-RING_1 PF14446.1 EPA05505.1 - 0.068 12.9 3.4 0.11 12.1 2.3 1.4 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Lar_restr_allev PF14354.1 EPA05505.1 - 0.072 13.4 2.2 0.74 10.1 1.5 2.0 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-UDP PF14569.1 EPA05505.1 - 0.1 12.3 0.4 0.12 12.1 0.3 1.1 1 0 0 1 1 1 0 Zinc-binding RING-finger zinc_ribbon_2 PF13240.1 EPA05505.1 - 0.12 11.9 1.9 9.4 5.8 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain ZZ PF00569.12 EPA05505.1 - 0.12 11.9 5.4 0.84 9.2 0.3 2.2 1 1 1 2 2 2 0 Zinc finger, ZZ type DNA_RNApol_7kD PF03604.8 EPA05505.1 - 0.12 11.8 3.8 1.7 8.1 2.7 2.1 1 1 1 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-C2H2_7 PF15269.1 EPA05505.1 - 0.14 12.0 0.2 0.17 11.7 0.1 1.1 1 0 0 1 1 1 0 Zinc-finger IBR PF01485.16 EPA05505.1 - 0.17 11.7 1.4 0.21 11.4 1.0 1.2 1 0 0 1 1 1 0 IBR domain DUF3133 PF11331.3 EPA05505.1 - 0.22 11.1 2.7 7.4 6.2 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3133) Sgf11 PF08209.6 EPA05505.1 - 0.22 10.8 4.1 1.1 8.6 0.1 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Zn_Tnp_IS1595 PF12760.2 EPA05505.1 - 0.23 11.3 1.8 0.6 9.9 1.4 1.6 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-CHY PF05495.7 EPA05505.1 - 0.26 11.4 2.6 0.41 10.8 1.8 1.3 1 1 0 1 1 1 0 CHY zinc finger DUF1451 PF07295.6 EPA05505.1 - 0.32 10.7 1.4 0.42 10.3 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1451) TFIIS_C PF01096.13 EPA05505.1 - 0.42 10.2 3.5 25 4.6 2.4 2.1 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS) zf-HYPF PF07503.7 EPA05505.1 - 0.52 9.7 3.0 7 6.1 0.1 2.2 2 0 0 2 2 2 0 HypF finger GCC2_GCC3 PF07699.8 EPA05505.1 - 0.68 9.5 4.0 2.1 7.9 2.7 1.7 1 1 0 1 1 1 0 GCC2 and GCC3 zf-C2H2_3 PF13878.1 EPA05505.1 - 1.4 8.5 5.1 3.1 7.4 0.3 2.2 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO Eapp_C PF10238.4 EPA05505.1 - 1.6 8.5 5.5 8.5 6.2 0.6 2.0 1 1 1 2 2 2 0 E2F-associated phosphoprotein GATA PF00320.22 EPA05505.1 - 2.1 7.7 5.6 45 3.5 0.2 2.2 1 1 1 2 2 2 0 GATA zinc finger UPF0547 PF10571.4 EPA05505.1 - 4.1 7.1 5.6 37 4.1 3.9 2.1 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 DUF3797 PF12677.2 EPA05505.1 - 4.4 6.9 8.6 3.7 7.2 0.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) AsnC_trans_reg PF01037.16 EPA05506.1 - 3.8e-13 48.9 0.1 7.1e-13 48.0 0.1 1.5 1 0 0 1 1 1 1 AsnC family B-block_TFIIIC PF04182.7 EPA05506.1 - 0.0051 16.6 0.3 0.008 16.0 0.2 1.7 1 1 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_24 PF13412.1 EPA05506.1 - 0.009 15.3 0.3 0.052 12.9 0.1 2.1 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding MarR PF01047.17 EPA05506.1 - 0.042 13.5 0.1 0.085 12.5 0.0 1.5 1 0 0 1 1 1 0 MarR family MotA_activ PF09114.5 EPA05506.1 - 0.078 12.7 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Transcription factor MotA, activation domain TrmB PF01978.14 EPA05506.1 - 0.095 12.4 0.4 0.21 11.3 0.1 1.7 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DUF2278 PF10042.4 EPA05506.1 - 0.11 12.2 0.2 0.13 11.9 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2278) His_Phos_1 PF00300.17 EPA05507.1 - 3.3e-35 121.5 0.0 3.8e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) CRM1_C PF08767.6 EPA05507.1 - 0.068 12.0 0.3 0.14 11.0 0.0 1.6 2 1 0 2 2 2 0 CRM1 C terminal CobS PF02654.10 EPA05508.1 - 6.3e-07 29.2 0.1 6.4e-07 29.2 0.1 1.0 1 0 0 1 1 1 1 Cobalamin-5-phosphate synthase F420_oxidored PF03807.12 EPA05509.1 - 8.4e-18 64.5 0.1 1.3e-17 64.0 0.0 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.11 EPA05509.1 - 0.0062 15.9 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.18 EPA05509.1 - 0.01 15.5 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Saccharop_dh PF03435.13 EPA05509.1 - 0.019 13.9 0.0 0.027 13.4 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase Semialdhyde_dh PF01118.19 EPA05509.1 - 0.02 15.1 0.0 0.032 14.5 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 EPA05509.1 - 0.021 14.7 0.1 0.037 13.9 0.1 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus PDH PF02153.12 EPA05509.1 - 0.048 12.5 0.0 0.064 12.1 0.0 1.3 1 0 0 1 1 1 0 Prephenate dehydrogenase Adenine_deam_C PF13382.1 EPA05510.1 - 8.1e-48 161.8 0.1 2.4e-47 160.2 0.0 1.8 2 0 0 2 2 2 1 Adenine deaminase C-terminal domain Amidohydro_1 PF01979.15 EPA05510.1 - 1.1e-17 64.6 0.0 7.8e-16 58.6 0.0 2.2 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EPA05510.1 - 4.7e-09 35.9 0.6 1.9e-08 33.9 0.0 2.2 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_3 PF07969.6 EPA05510.1 - 0.0029 16.8 0.0 0.16 11.1 0.0 2.2 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_4 PF13147.1 EPA05510.1 - 0.01 15.8 0.0 0.12 12.4 0.0 2.1 2 0 0 2 2 2 0 Amidohydrolase DUF2099 PF09872.4 EPA05510.1 - 0.063 12.2 0.1 0.25 10.3 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2099) Inhibitor_I29 PF08246.7 EPA05511.1 - 0.021 15.0 1.0 0.021 15.0 0.7 2.7 2 0 0 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) NTP_transf_3 PF12804.2 EPA05512.1 - 5e-14 52.6 0.0 6.3e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.14 EPA05512.1 - 8.2e-08 32.0 0.0 1.1e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NTP_transferase PF00483.18 EPA05512.1 - 0.00025 20.4 0.1 0.00038 19.8 0.0 1.5 1 1 0 1 1 1 1 Nucleotidyl transferase NIF PF03031.13 EPA05512.1 - 0.0011 18.7 0.3 0.11 12.0 0.1 2.3 1 1 1 2 2 2 2 NLI interacting factor-like phosphatase CTP_transf_3 PF02348.14 EPA05512.1 - 0.054 13.1 0.1 0.07 12.7 0.0 1.4 1 1 0 1 1 1 0 Cytidylyltransferase Peptidase_C98 PF15499.1 EPA05512.1 - 0.11 11.7 0.2 0.11 11.7 0.1 1.7 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF308 PF03729.8 EPA05514.1 - 0.0032 17.4 1.1 0.3 11.1 0.1 2.1 2 0 0 2 2 2 2 Short repeat of unknown function (DUF308) Gram_pos_anchor PF00746.16 EPA05514.1 - 0.0067 16.1 0.4 0.081 12.7 0.0 2.0 2 0 0 2 2 2 1 Gram positive anchor YfzA PF14118.1 EPA05514.1 - 0.02 14.9 0.8 0.032 14.3 0.5 1.4 1 1 0 1 1 1 0 YfzA-like protein Tetraspannin PF00335.15 EPA05514.1 - 0.044 13.0 2.2 0.054 12.7 1.5 1.0 1 0 0 1 1 1 0 Tetraspanin family DctQ PF04290.7 EPA05514.1 - 0.063 13.0 1.0 0.086 12.5 0.7 1.3 1 1 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF334 PF03904.8 EPA05514.1 - 0.11 11.8 0.2 0.1 11.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF334) DUF202 PF02656.10 EPA05514.1 - 1.3 9.2 3.4 13 6.0 2.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF202) VPEP PF07589.6 EPA05514.1 - 4.6 7.2 7.3 1.5 8.8 0.6 2.2 2 0 0 2 2 2 0 PEP-CTERM motif Ribosomal_L44 PF00935.14 EPA05515.1 - 2.5e-25 88.2 8.7 2.5e-25 88.2 6.0 1.5 1 1 1 2 2 2 1 Ribosomal protein L44 C1_1 PF00130.17 EPA05515.1 - 0.079 12.6 0.7 3.6 7.3 0.0 2.1 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-met PF12874.2 EPA05515.1 - 2 8.7 5.2 5.6 7.3 0.4 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type CPDase PF07823.6 EPA05516.1 - 1.6e-15 57.1 2.9 2.1e-15 56.7 2.0 1.1 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.1 EPA05516.1 - 5.6e-07 29.4 0.0 7.5e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily HVSL PF09749.4 EPA05516.1 - 0.0083 15.1 0.6 0.016 14.2 0.1 1.7 3 0 0 3 3 3 1 Uncharacterised conserved protein LigT_PEase PF02834.11 EPA05516.1 - 0.0084 16.0 0.1 3.5 7.6 0.0 2.2 2 0 0 2 2 2 2 LigT like Phosphoesterase HTH_22 PF13309.1 EPA05516.1 - 0.071 12.8 1.2 0.27 11.0 0.3 2.4 2 1 0 2 2 2 0 HTH domain UPF0449 PF15136.1 EPA05516.1 - 0.12 12.5 0.3 0.21 11.7 0.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 EMP24_GP25L PF01105.19 EPA05517.1 - 0.0056 16.4 0.0 0.0077 15.9 0.0 1.3 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Big_3 PF07523.7 EPA05517.1 - 0.034 14.2 0.3 0.1 12.6 0.2 1.8 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) DUF3244 PF11589.3 EPA05517.1 - 0.035 13.8 2.4 0.54 9.9 0.5 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF3244) FlgD_ig PF13860.1 EPA05517.1 - 0.047 13.4 0.5 0.99 9.1 0.1 2.3 1 1 1 2 2 2 0 FlgD Ig-like domain Spore_YhaL PF14147.1 EPA05517.1 - 0.29 10.6 1.6 0.34 10.3 0.1 1.9 2 0 0 2 2 2 0 Sporulation protein YhaL ROK PF00480.15 EPA05518.1 - 2.4e-48 164.3 2.2 3.2e-48 163.9 1.5 1.2 1 0 0 1 1 1 1 ROK family BcrAD_BadFG PF01869.15 EPA05518.1 - 0.001 18.4 0.3 0.0041 16.4 0.1 2.1 2 1 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family Hydant_A_N PF05378.8 EPA05518.1 - 0.0052 16.3 0.0 0.0086 15.5 0.0 1.3 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase N-terminal region FGGY_N PF00370.16 EPA05518.1 - 0.11 11.7 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain CobD_Cbib PF03186.8 EPA05519.1 - 2.7e-96 322.1 0.0 3.3e-96 321.8 0.0 1.1 1 0 0 1 1 1 1 CobD/Cbib protein Pyridox_oxidase PF01243.15 EPA05520.1 - 4.6e-13 48.9 0.0 1.2e-12 47.6 0.0 1.6 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase GatB_Yqey PF02637.13 EPA05520.1 - 0.028 14.1 1.4 0.028 14.1 1.0 1.5 2 0 0 2 2 2 0 GatB domain UbiD PF01977.11 EPA05521.1 - 3.1e-103 345.3 0.1 3.6e-103 345.1 0.1 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase PGP_phosphatase PF09419.5 EPA05521.1 - 0.073 12.4 0.5 1.3 8.3 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase Cpn60_TCP1 PF00118.19 EPA05522.1 - 1.1e-162 542.0 16.2 1.4e-162 541.7 11.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Semialdhyde_dhC PF02774.13 EPA05523.1 - 4.5e-36 124.4 0.0 6.8e-36 123.8 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.19 EPA05523.1 - 4.8e-29 101.1 0.0 9.4e-29 100.1 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Paramyxo_PCT PF14320.1 EPA05523.1 - 0.014 14.2 0.1 0.024 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoprotein P region PCT disordered Gp_dh_C PF02800.15 EPA05523.1 - 0.036 13.5 0.6 0.87 9.0 0.1 2.5 2 1 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain DapB_N PF01113.15 EPA05523.1 - 0.038 13.8 0.0 0.072 13.0 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.17 EPA05523.1 - 0.069 13.6 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold DXP_reductoisom PF02670.11 EPA05523.1 - 0.1 13.1 0.0 0.21 12.1 0.0 1.6 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase HATPase_c PF02518.21 EPA05524.1 - 9.9e-24 83.2 0.0 1.7e-23 82.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EPA05524.1 - 4.2e-12 45.8 0.4 8.7e-12 44.8 0.1 1.7 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.1 EPA05524.1 - 4.1e-06 26.4 0.0 9.9e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.1 EPA05524.1 - 3.5e-05 23.4 0.1 0.00012 21.7 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 EPA05524.1 - 0.015 15.0 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain MAPKK1_Int PF08923.5 EPA05524.1 - 0.021 14.4 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 Mitogen-activated protein kinase kinase 1 interacting TMEM154 PF15102.1 EPA05524.1 - 0.038 13.6 1.3 0.14 11.8 0.1 2.2 2 0 0 2 2 2 0 TMEM154 protein family 7TMR-DISM_7TM PF07695.6 EPA05524.1 - 2 8.0 42.4 2.6 7.6 19.3 2.3 1 1 1 2 2 2 0 7TM diverse intracellular signalling COX2 PF00116.15 EPA05525.1 - 5.1e-20 71.4 1.9 2e-17 63.1 0.1 2.1 1 1 1 2 2 2 2 Cytochrome C oxidase subunit II, periplasmic domain Cupredoxin_1 PF13473.1 EPA05525.1 - 6.2e-05 22.8 0.0 7.7e-05 22.5 0.0 1.3 1 1 0 1 1 1 1 Cupredoxin-like domain DUF59 PF01883.14 EPA05526.1 - 1.2e-15 57.2 0.3 2.7e-15 56.0 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function DUF59 PqqD PF05402.7 EPA05526.1 - 5.4e-09 35.9 0.1 8.2e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) HemN_C PF06969.11 EPA05526.1 - 0.027 14.5 0.2 0.059 13.4 0.2 1.5 1 0 0 1 1 1 0 HemN C-terminal domain Aminotran_1_2 PF00155.16 EPA05527.1 - 1.6e-51 175.3 0.0 1.9e-51 175.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.8 EPA05527.1 - 0.0038 15.9 0.0 0.0057 15.3 0.0 1.3 1 0 0 1 1 1 1 Allinase Aminotran_5 PF00266.14 EPA05527.1 - 0.018 13.8 0.0 0.039 12.6 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class-V Aminotran_1_2 PF00155.16 EPA05528.1 - 1.7e-56 191.7 0.0 2e-56 191.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 EPA05528.1 - 4.2e-08 32.6 0.0 6.9e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 EPA05528.1 - 2.4e-07 29.8 0.0 4.3e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EPA05528.1 - 0.00011 20.5 0.0 0.00016 20.1 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 EPA05528.1 - 0.0061 15.7 0.0 0.012 14.7 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase 4HBT PF03061.17 EPA05529.1 - 1.1e-14 54.2 0.1 1.6e-14 53.7 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily MaoC_dehydratas PF01575.14 EPA05529.1 - 0.00068 19.0 0.1 0.0011 18.3 0.1 1.3 1 0 0 1 1 1 1 MaoC like domain CTX_RstB PF07459.6 EPA05529.1 - 0.016 15.0 0.1 0.025 14.4 0.1 1.3 1 0 0 1 1 1 0 CTX phage RstB protein OspE PF02471.12 EPA05529.1 - 0.042 13.7 0.1 0.066 13.1 0.1 1.3 1 0 0 1 1 1 0 Borrelia outer surface protein E Caenor_Her-1 PF09232.5 EPA05529.1 - 0.1 12.6 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Caenorhabditis elegans Her-1 CobS PF02654.10 EPA05530.1 - 1.4e-41 142.6 7.5 1.5e-41 142.5 5.2 1.0 1 0 0 1 1 1 1 Cobalamin-5-phosphate synthase UbiA PF01040.13 EPA05530.1 - 0.00031 20.0 6.2 0.00041 19.6 4.3 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family EcsB PF05975.7 EPA05530.1 - 0.069 11.6 3.0 0.072 11.5 1.6 1.4 1 1 0 1 1 1 0 Bacterial ABC transporter protein EcsB DUF3040 PF11239.3 EPA05530.1 - 2.9 7.9 5.9 3.2 7.8 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) PRA1 PF03208.14 EPA05530.1 - 3.4 6.9 5.9 6 6.1 4.0 1.5 1 1 0 1 1 1 0 PRA1 family protein RseC_MucC PF04246.7 EPA05530.1 - 4.1 6.9 10.8 0.24 10.9 1.4 2.2 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Ribonuc_2-5A PF06479.7 EPA05531.1 - 0.0011 18.8 2.5 0.0015 18.3 1.3 1.6 1 1 0 1 1 1 1 Ribonuclease 2-5A Phage_min_cap2 PF06152.6 EPA05531.1 - 0.0021 17.1 1.7 0.0023 16.9 1.2 1.1 1 0 0 1 1 1 1 Phage minor capsid protein 2 Sec5 PF15469.1 EPA05531.1 - 0.0046 16.7 4.2 0.045 13.4 2.9 2.0 1 1 0 1 1 1 1 Exocyst complex component Sec5 ERp29 PF07749.7 EPA05531.1 - 0.013 16.1 4.2 1.1 9.9 0.4 2.6 1 1 2 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain DDE_Tnp_ISL3 PF01610.12 EPA05531.1 - 0.02 14.4 9.4 0.11 12.0 0.3 2.2 1 1 1 2 2 2 0 Transposase RRF PF01765.14 EPA05531.1 - 0.025 14.0 1.3 0.05 13.0 0.4 1.8 1 1 1 2 2 2 0 Ribosome recycling factor Dak2 PF02734.12 EPA05531.1 - 0.056 13.1 0.0 0.23 11.1 0.0 1.9 1 1 1 2 2 2 0 DAK2 domain FCH PF00611.18 EPA05531.1 - 0.057 13.6 7.4 2.6 8.2 3.8 2.9 1 1 1 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Chalcone PF02431.10 EPA05531.1 - 0.078 12.3 2.5 0.32 10.3 1.6 2.1 1 1 0 1 1 1 0 Chalcone-flavanone isomerase YkyA PF10368.4 EPA05531.1 - 0.08 12.2 5.2 0.53 9.5 1.3 2.4 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein SF-assemblin PF06705.6 EPA05531.1 - 0.1 11.6 1.4 0.87 8.6 1.0 2.0 1 1 0 1 1 1 0 SF-assemblin/beta giardin DUF4415 PF14384.1 EPA05531.1 - 0.16 12.1 6.0 1.4 9.1 0.6 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4415) DUF1215 PF06744.7 EPA05531.1 - 0.17 11.5 4.9 0.098 12.3 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1215) DUF2884 PF11101.3 EPA05531.1 - 0.2 10.9 9.5 0.26 10.6 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) Spore_III_AB PF09548.5 EPA05531.1 - 0.21 11.3 8.5 0.64 9.7 5.5 2.0 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) DUF2309 PF10070.4 EPA05531.1 - 0.21 9.6 6.3 0.24 9.4 4.3 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2309) T4SS PF07996.6 EPA05531.1 - 0.23 11.3 8.4 0.38 10.5 5.8 1.3 1 1 0 1 1 1 0 Type IV secretion system proteins ATC_hydrolase PF14196.1 EPA05531.1 - 0.34 11.3 3.9 0.5 10.7 1.9 1.8 1 1 0 1 1 1 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase His_Phos_1 PF00300.17 EPA05531.1 - 0.35 10.9 3.1 6.9 6.7 0.0 2.5 1 1 1 2 2 2 0 Histidine phosphatase superfamily (branch 1) DASH_Dad2 PF08654.5 EPA05531.1 - 0.5 10.3 8.4 3.7 7.6 1.6 2.8 1 1 2 3 3 3 0 DASH complex subunit Dad2 ALIX_LYPXL_bnd PF13949.1 EPA05531.1 - 0.52 9.2 8.3 0.87 8.4 5.6 1.6 1 1 0 1 1 1 0 ALIX V-shaped domain binding to HIV CMAS PF02353.15 EPA05531.1 - 0.94 8.5 9.6 0.75 8.8 2.4 2.4 1 1 1 2 2 2 0 Mycolic acid cyclopropane synthetase DUF745 PF05335.8 EPA05531.1 - 1.5 8.3 5.2 0.88 9.0 1.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF2714 PF10896.3 EPA05531.1 - 2.5 7.8 7.1 0.65 9.8 0.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2714) OmpH PF03938.9 EPA05531.1 - 2.9 7.7 6.4 6.7 6.6 4.4 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) YfbU PF03887.9 EPA05531.1 - 3.6 7.1 7.2 0.4 10.2 0.7 2.1 1 1 1 2 2 2 0 YfbU domain DUF4413 PF14372.1 EPA05531.1 - 4.6 7.2 8.6 0.37 10.7 1.2 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4413) DUF3080 PF11279.3 EPA05531.1 - 5 6.1 10.0 6.9 5.7 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3080) Methyltransf_11 PF08241.7 EPA05532.1 - 1e-15 58.0 0.0 1.8e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA05532.1 - 2.6e-14 53.0 0.1 3.4e-14 52.6 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EPA05532.1 - 6e-14 52.2 0.0 1.2e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA05532.1 - 1.8e-08 34.2 0.0 3.1e-08 33.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA05532.1 - 1.4e-07 31.9 0.0 2.5e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EPA05532.1 - 1.9e-06 27.9 0.0 2.9e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA05532.1 - 1.4e-05 25.6 0.0 1.7e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EPA05532.1 - 4.8e-05 22.5 0.1 6.2e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.7 EPA05532.1 - 0.00045 19.6 0.0 0.00074 18.9 0.0 1.3 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.8 EPA05532.1 - 0.0015 17.7 0.0 0.0017 17.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DUF4145 PF13643.1 EPA05532.1 - 0.0017 18.1 0.2 0.003 17.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4145) TPMT PF05724.6 EPA05532.1 - 0.0027 17.1 0.0 0.0061 16.0 0.0 1.7 2 0 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) MTS PF05175.9 EPA05532.1 - 0.0039 16.5 0.0 0.0089 15.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain Ribosomal_L18_c PF14204.1 EPA05532.1 - 0.0098 16.4 2.4 0.51 10.9 0.1 2.3 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Aida_N PF08910.5 EPA05532.1 - 0.039 14.1 0.0 11 6.3 0.0 2.2 2 0 0 2 2 2 0 Aida N-terminus DUF1308 PF07000.6 EPA05532.1 - 0.059 12.0 0.0 0.079 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1308) MscS_porin PF12795.2 EPA05533.1 - 0.0037 16.6 1.2 0.0037 16.6 0.8 2.1 2 1 0 2 2 2 1 Mechanosensitive ion channel porin domain DUF3800 PF12686.2 EPA05533.1 - 0.035 13.7 0.0 0.06 12.9 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Phage_int_SAM_1 PF02899.12 EPA05533.1 - 0.037 14.1 0.7 1.4 9.1 0.2 2.3 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain DUF883 PF05957.8 EPA05533.1 - 0.097 13.0 0.1 18 5.8 0.0 2.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) ERp29 PF07749.7 EPA05533.1 - 0.28 11.8 2.6 17 6.1 0.0 2.9 2 1 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain ApoLp-III PF07464.6 EPA05533.1 - 0.43 10.5 6.2 4.7 7.2 4.2 2.5 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF327 PF03885.8 EPA05533.1 - 5.4 6.8 6.9 8.6 6.1 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF327) DUF2024 PF09630.5 EPA05534.1 - 8.1e-36 121.6 3.1 8.9e-36 121.4 2.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2024) RE_TdeIII PF09520.5 EPA05534.1 - 0.0038 16.5 0.1 0.0041 16.4 0.0 1.2 1 0 0 1 1 1 1 Type II restriction endonuclease, TdeIII CCG PF02754.11 EPA05534.1 - 0.067 13.2 0.1 0.097 12.6 0.1 1.2 1 0 0 1 1 1 0 Cysteine-rich domain HSP70 PF00012.15 EPA05535.1 - 1.4e-197 657.3 13.1 1.7e-197 657.0 9.1 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EPA05535.1 - 1.5e-16 59.9 2.4 1.5e-16 59.9 1.6 1.9 2 1 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 EPA05535.1 - 0.00057 19.5 0.0 0.001 18.7 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Peptidase_M22 PF00814.20 EPA05535.1 - 0.064 12.7 0.0 0.17 11.3 0.0 1.7 1 0 0 1 1 1 0 Glycoprotease family DUF1664 PF07889.7 EPA05535.1 - 1.3 8.8 6.7 0.36 10.6 0.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Prominin PF05478.6 EPA05535.1 - 8.7 3.7 10.4 12 3.2 7.2 1.2 1 0 0 1 1 1 0 Prominin DnaJ PF00226.26 EPA05536.1 - 1.1e-21 76.3 0.1 1.2e-21 76.1 0.1 1.0 1 0 0 1 1 1 1 DnaJ domain PUA PF01472.15 EPA05537.1 - 6.3e-10 38.6 0.0 1.6e-09 37.3 0.0 1.6 2 0 0 2 2 2 1 PUA domain TGT_C2 PF14810.1 EPA05537.1 - 2.9e-09 36.6 0.0 4.9e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Patch-forming domain C2 of tRNA-guanine transglycosylase DUF460 PF04312.8 EPA05538.1 - 0.00057 19.4 0.1 0.00078 18.9 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF460) UPF0081 PF03652.10 EPA05538.1 - 0.029 14.4 0.0 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0081) NAC PF01849.13 EPA05539.1 - 1.2e-15 56.7 1.8 2.3e-15 55.8 1.3 1.5 1 0 0 1 1 1 1 NAC domain UBA PF00627.26 EPA05539.1 - 9.8e-06 25.2 0.2 9.8e-06 25.2 0.1 1.7 2 0 0 2 2 2 1 UBA/TS-N domain UBA_4 PF14555.1 EPA05539.1 - 0.0098 15.4 0.1 0.014 14.9 0.1 1.2 1 0 0 1 1 1 1 UBA-like domain Cytidylate_kin2 PF13189.1 EPA05539.1 - 0.094 12.6 0.9 0.46 10.3 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase-like family ATP-synt_DE PF00401.15 EPA05539.1 - 0.21 11.4 2.0 0.37 10.6 1.4 1.4 1 0 0 1 1 1 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain PhoU PF01895.14 EPA05540.1 - 9.9e-28 96.4 16.5 7.4e-19 67.9 1.9 2.5 2 0 0 2 2 2 2 PhoU domain Antitoxin-MazE PF04014.13 EPA05540.1 - 5.1e-08 32.4 0.1 1.9e-07 30.6 0.0 2.2 2 0 0 2 2 2 1 Antidote-toxin recognition MazE Cys_rich_CPCC PF14206.1 EPA05541.1 - 0.27 10.8 5.2 0.13 11.7 0.7 2.2 2 1 0 2 2 2 0 Cysteine-rich CPCC DivIVA PF05103.8 EPA05542.1 - 0.0012 18.8 6.1 0.0017 18.4 4.3 1.2 1 0 0 1 1 1 1 DivIVA protein MitMem_reg PF13012.1 EPA05542.1 - 0.0056 16.7 3.9 0.0086 16.1 2.7 1.4 1 1 0 1 1 1 1 Maintenance of mitochondrial structure and function TMCO5 PF14992.1 EPA05542.1 - 0.0089 15.1 6.0 0.0099 15.0 4.1 1.0 1 0 0 1 1 1 1 TMCO5 family HAUS2 PF15003.1 EPA05542.1 - 0.011 14.8 0.7 0.013 14.6 0.5 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 2 Apolipoprotein PF01442.13 EPA05542.1 - 0.011 15.2 1.5 0.017 14.6 1.1 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Muted PF14942.1 EPA05542.1 - 0.018 14.9 3.0 0.024 14.5 2.1 1.1 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein ATP-synt_B PF00430.13 EPA05542.1 - 0.023 14.5 7.1 0.038 13.7 4.4 1.6 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) COG6 PF06419.6 EPA05542.1 - 0.024 12.7 4.8 0.029 12.5 3.3 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Peptidase_C12 PF01088.16 EPA05542.1 - 0.029 13.5 1.2 0.036 13.2 0.9 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase, family 1 CsoSCA PF08936.5 EPA05542.1 - 0.031 12.6 0.9 0.035 12.4 0.6 1.1 1 0 0 1 1 1 0 Carboxysome Shell Carbonic Anhydrase DUF948 PF06103.6 EPA05542.1 - 0.042 13.7 4.7 0.089 12.6 0.3 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.7 EPA05542.1 - 0.043 14.0 4.6 1 9.6 3.2 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein TFIIA_gamma_N PF02268.11 EPA05542.1 - 0.061 12.9 0.2 0.13 11.8 0.2 1.5 1 0 0 1 1 1 0 Transcription initiation factor IIA, gamma subunit, helical domain DUF972 PF06156.8 EPA05542.1 - 0.076 13.3 5.9 0.12 12.7 4.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF972) V-ATPase_G PF03179.10 EPA05542.1 - 0.077 13.2 7.3 0.12 12.7 5.1 1.4 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit CHASE3 PF05227.8 EPA05542.1 - 0.08 12.6 1.8 0.21 11.2 1.3 1.5 1 1 1 2 2 2 0 CHASE3 domain CorA PF01544.13 EPA05542.1 - 0.089 11.8 0.8 0.094 11.7 0.6 1.0 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Mitofilin PF09731.4 EPA05542.1 - 0.13 10.9 8.9 0.15 10.6 6.2 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Baculo_PEP_C PF04513.7 EPA05542.1 - 0.14 11.9 3.8 0.22 11.3 0.5 2.1 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF848 PF05852.6 EPA05542.1 - 0.18 11.6 5.9 0.45 10.3 4.1 1.6 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Peptidase_M4 PF01447.13 EPA05542.1 - 0.2 11.7 1.2 0.23 11.5 0.8 1.1 1 0 0 1 1 1 0 Thermolysin metallopeptidase, catalytic domain Syntaxin_2 PF14523.1 EPA05542.1 - 0.22 11.5 6.8 0.39 10.7 4.7 1.5 1 1 0 1 1 1 0 Syntaxin-like protein SMAP PF15477.1 EPA05542.1 - 0.38 11.0 2.2 0.72 10.1 1.5 1.6 1 1 0 1 1 1 0 Small acidic protein family Sox_N PF12444.3 EPA05542.1 - 0.39 11.8 1.6 0.58 11.2 1.1 1.6 1 1 0 1 1 1 0 Sox developmental protein N terminal Phasin PF05597.6 EPA05542.1 - 0.53 10.0 6.9 2.6 7.8 2.6 2.1 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF883 PF05957.8 EPA05542.1 - 0.72 10.2 3.2 6.1 7.3 1.4 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Spc24 PF08286.6 EPA05542.1 - 1.1 9.0 7.4 9.2 5.9 5.1 2.1 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 FlaC_arch PF05377.6 EPA05542.1 - 1.4 8.8 4.4 3.5 7.6 0.6 2.4 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Pup PF05639.6 EPA05542.1 - 1.4 9.4 4.2 20 5.7 0.3 2.3 1 1 1 2 2 2 0 Pup-like protein IZUMO PF15005.1 EPA05544.1 - 0.076 13.0 5.3 0.089 12.8 3.7 1.0 1 0 0 1 1 1 0 Izumo sperm-egg fusion TGFb_propeptide PF00688.13 EPA05545.1 - 0.044 13.0 0.0 2.8 7.1 0.0 2.1 2 0 0 2 2 2 0 TGF-beta propeptide zf-RanBP PF00641.13 EPA05546.1 - 0.081 12.0 1.2 4 6.6 0.0 2.1 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others XPA_N PF01286.13 EPA05546.1 - 0.11 12.1 1.7 5.4 6.7 0.0 2.5 2 1 1 3 3 3 0 XPA protein N-terminal LIM PF00412.17 EPA05546.1 - 0.12 12.4 0.1 1.6 8.8 0.2 2.0 1 1 1 2 2 2 0 LIM domain DUF2116 PF09889.4 EPA05546.1 - 0.16 11.7 0.8 7.1 6.5 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) zf-C3HC4_3 PF13920.1 EPA05546.1 - 0.21 11.3 1.5 2.6 7.7 0.1 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Acetyltransf_1 PF00583.19 EPA05547.1 - 5.9e-18 64.6 0.0 7.5e-18 64.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EPA05547.1 - 3.2e-15 56.0 0.1 4.1e-15 55.7 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EPA05547.1 - 2e-12 47.2 0.0 2.3e-12 47.0 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EPA05547.1 - 3.8e-09 36.6 0.2 4.8e-09 36.3 0.1 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EPA05547.1 - 2.5e-08 33.9 0.0 3.8e-08 33.3 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EPA05547.1 - 1.3e-05 25.0 0.0 1.8e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EPA05547.1 - 0.00019 21.0 0.0 0.0003 20.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.1 EPA05547.1 - 0.00048 20.3 0.0 0.00058 20.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 EPA05547.1 - 0.00083 18.9 0.0 0.00098 18.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EPA05547.1 - 0.0022 17.8 0.0 0.0034 17.2 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Peptidase_S8 PF00082.17 EPA05548.1 - 1e-23 83.8 10.0 2.8e-18 66.0 0.6 2.4 1 1 0 2 2 2 2 Subtilase family Mis12 PF05859.7 EPA05548.1 - 0.0051 16.6 0.7 0.011 15.5 0.5 1.5 1 0 0 1 1 1 1 Mis12 protein DZR PF12773.2 EPA05549.1 - 0.012 15.4 1.0 0.015 15.0 0.7 1.1 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.1 EPA05549.1 - 0.039 13.1 2.7 1.3 8.3 0.4 2.1 1 1 1 2 2 2 0 zinc-ribbon domain FHIPEP PF00771.15 EPA05549.1 - 0.04 12.2 0.0 0.04 12.2 0.0 1.0 1 0 0 1 1 1 0 FHIPEP family zf-C3HC4_3 PF13920.1 EPA05549.1 - 0.044 13.4 1.0 0.06 13.0 0.7 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PolC_DP2 PF03833.8 EPA05549.1 - 0.055 11.1 0.0 0.055 11.1 0.0 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DUF1272 PF06906.6 EPA05549.1 - 0.081 12.7 1.7 0.12 12.2 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zinc_ribbon_2 PF13240.1 EPA05549.1 - 0.12 11.8 3.4 5.6 6.5 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain DUF2321 PF10083.4 EPA05549.1 - 0.13 11.7 0.2 0.16 11.4 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) PHO4 PF01384.15 EPA05549.1 - 0.13 10.8 0.1 0.14 10.7 0.1 1.1 1 0 0 1 1 1 0 Phosphate transporter family TF_Zn_Ribbon PF08271.7 EPA05549.1 - 2.9 7.2 6.3 5.1 6.4 0.8 2.2 1 1 1 2 2 2 0 TFIIB zinc-binding eIF-3c_N PF05470.7 EPA05550.1 - 0.16 10.0 7.5 0.17 9.9 5.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus NPR3 PF03666.8 EPA05550.1 - 2.5 6.5 17.0 3.1 6.2 11.8 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BTV_NS2 PF04514.7 EPA05550.1 - 3.8 6.2 9.3 4 6.2 6.5 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 GEMIN8 PF15348.1 EPA05550.1 - 5.8 6.8 11.5 7.5 6.5 8.0 1.3 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 DUF3807 PF12720.2 EPA05550.1 - 9.1 6.4 13.7 12 5.9 9.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) HDC PF02329.11 EPA05551.1 - 0.038 12.6 1.1 0.46 9.0 0.1 2.0 1 1 1 2 2 2 0 Histidine carboxylase PI chain Oxidored_q2 PF00420.19 EPA05552.1 - 3.3e-22 77.8 4.3 3.9e-22 77.6 3.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L NADHdh PF00146.16 EPA05553.1 - 9.6e-55 185.8 7.7 1.1e-54 185.6 5.3 1.0 1 0 0 1 1 1 1 NADH dehydrogenase DUF1426 PF07234.6 EPA05553.1 - 2.5 7.8 4.5 2.5 7.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1426) Oxidored_q1 PF00361.15 EPA05554.1 - 2.5e-57 194.2 25.3 1.1e-52 179.0 17.2 3.4 4 1 0 4 4 4 2 NADH-Ubiquinone/plastoquinone (complex I), various chains Oxidored_q1_N PF00662.15 EPA05554.1 - 1.2e-11 44.0 1.5 5.1e-11 41.9 1.1 2.1 1 0 0 1 1 1 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Oxidored_q1_C PF01010.14 EPA05554.1 - 0.0038 16.7 0.1 0.0074 15.8 0.1 1.6 1 0 0 1 1 1 1 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus Oxidored_q1 PF00361.15 EPA05555.1 - 2.7e-61 207.1 25.3 2.7e-61 207.1 17.5 2.9 4 0 0 4 4 4 1 NADH-Ubiquinone/plastoquinone (complex I), various chains Oxidored_q1_N PF00662.15 EPA05555.1 - 0.0052 16.3 0.7 0.042 13.4 0.1 2.7 2 0 0 2 2 2 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus DUF1515 PF07439.6 EPA05555.1 - 0.12 12.1 1.3 0.95 9.2 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Oxidored_q3 PF00499.15 EPA05556.1 - 3.1e-21 75.6 12.5 3.8e-21 75.3 8.6 1.1 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF4040 PF13244.1 EPA05556.1 - 0.0041 17.0 8.7 0.0041 17.0 6.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4040) MIG-14_Wnt-bd PF06664.7 EPA05556.1 - 0.048 12.4 3.7 0.065 12.0 2.5 1.4 1 1 0 1 1 1 0 Wnt-binding factor required for Wnt secretion NfeD PF01957.13 EPA05556.1 - 0.79 9.8 13.0 0.15 12.1 5.5 2.1 1 1 1 2 2 2 0 NfeD-like C-terminal, partner-binding DUF4131 PF13567.1 EPA05556.1 - 1.4 8.2 7.0 0.44 9.9 0.9 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) UPF0104 PF03706.8 EPA05556.1 - 2.1 7.5 15.6 15 4.7 11.1 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0104) Fer4 PF00037.22 EPA05557.1 - 6.2e-12 44.5 10.8 2.6e-09 36.2 1.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.1 EPA05557.1 - 6.7e-10 38.6 16.7 1.4e-06 27.9 6.8 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.2 EPA05557.1 - 1.3e-09 38.2 9.8 2.1e-09 37.5 6.8 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.1 EPA05557.1 - 3.7e-09 36.3 19.3 1.7e-06 27.7 7.1 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.2 EPA05557.1 - 2.5e-08 33.3 10.5 6.8e-05 22.5 1.7 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.1 EPA05557.1 - 4.7e-07 29.9 8.8 8.2e-07 29.2 6.1 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.1 EPA05557.1 - 1.6e-06 28.0 17.9 6e-05 22.9 6.8 1.8 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_17 PF13534.1 EPA05557.1 - 3.2e-06 27.3 7.1 0.0033 17.7 0.2 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.2 EPA05557.1 - 5.1e-06 26.1 1.8 5.1e-06 26.1 1.2 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_16 PF13484.1 EPA05557.1 - 1.6e-05 25.5 17.3 0.00071 20.2 6.6 1.8 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_4 PF12800.2 EPA05557.1 - 3e-05 23.9 9.1 0.0024 18.0 0.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.1 EPA05557.1 - 0.00045 20.7 4.6 0.096 13.2 0.2 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_13 PF13370.1 EPA05557.1 - 0.0023 18.2 4.5 0.23 11.8 0.1 2.4 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_18 PF13746.1 EPA05557.1 - 0.0026 18.1 11.8 0.004 17.5 0.7 2.3 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_3 PF12798.2 EPA05557.1 - 0.0031 17.9 17.3 0.0057 17.1 2.8 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain DUF2607 PF10795.4 EPA05557.1 - 0.033 14.0 0.4 0.058 13.2 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2607) EMP24_GP25L PF01105.19 EPA05558.1 - 0.037 13.7 0.0 0.069 12.8 0.0 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD A2M_N PF01835.14 EPA05558.1 - 0.06 13.5 0.0 0.09 13.0 0.0 1.3 1 0 0 1 1 1 0 MG2 domain DUF3255 PF11631.3 EPA05558.1 - 0.069 12.7 0.2 1.5 8.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3255) Filamin PF00630.14 EPA05558.1 - 0.14 12.7 0.0 0.2 12.2 0.0 1.3 1 0 0 1 1 1 0 Filamin/ABP280 repeat NUDIX PF00293.23 EPA05559.1 - 2e-14 53.3 0.0 2.8e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain AA_kinase PF00696.23 EPA05561.1 - 1.8e-29 103.0 0.0 2e-29 102.8 0.0 1.0 1 0 0 1 1 1 1 Amino acid kinase family DUF1967 PF09269.6 EPA05561.1 - 0.017 14.8 0.0 0.3 10.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1967) DUF3413 PF11893.3 EPA05562.1 - 0.014 14.3 1.2 0.014 14.2 0.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) DUF1430 PF07242.6 EPA05562.1 - 0.13 12.3 2.8 0.13 12.3 2.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1430) DUF3043 PF11241.3 EPA05562.1 - 0.32 10.5 1.4 0.31 10.6 0.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF4027 PF13219.1 EPA05562.1 - 0.91 9.0 3.2 1.5 8.3 2.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4027) SdpI PF13630.1 EPA05562.1 - 2.2 8.0 6.2 2.6 7.8 4.3 1.1 1 0 0 1 1 1 0 SdpI/YhfL protein family Ribosomal_S2 PF00318.15 EPA05563.1 - 8.8e-34 116.5 0.3 3.9e-16 58.9 0.4 2.0 1 1 1 2 2 2 2 Ribosomal protein S2 Trypan_PARP PF05887.6 EPA05564.1 - 8.5e-05 22.3 3.0 8.5e-05 22.3 2.1 1.7 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) DUF4369 PF14289.1 EPA05564.1 - 0.037 14.0 0.2 0.069 13.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4369) CarboxypepD_reg PF13620.1 EPA05564.1 - 0.12 12.4 1.1 0.25 11.4 0.8 1.6 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain EB PF01683.13 EPA05564.1 - 0.13 12.3 7.2 4.1 7.5 0.6 3.9 2 2 0 2 2 2 0 EB module PLRV_ORF5 PF01690.12 EPA05564.1 - 0.33 10.0 6.5 0.44 9.6 4.5 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Translin PF01997.11 EPA05565.1 - 2.3e-31 108.9 0.8 3.1e-31 108.5 0.6 1.2 1 0 0 1 1 1 1 Translin family Cation_efflux PF01545.16 EPA05566.1 - 5.2e-77 258.7 27.3 9.3e-63 211.9 6.8 3.0 2 1 1 3 3 3 3 Cation efflux family BON PF04972.12 EPA05566.1 - 0.24 11.1 3.5 0.26 11.0 0.2 2.7 3 0 0 3 3 3 0 BON domain AMP-binding_C_2 PF14535.1 EPA05566.1 - 0.28 11.2 10.1 1.1 9.2 1.0 3.2 2 1 1 3 3 3 0 AMP-binding enzyme C-terminal domain DUF4131 PF13567.1 EPA05566.1 - 1.1 8.6 3.4 5.8 6.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) ATP_synt_I PF03899.10 EPA05566.1 - 4.6 7.4 11.4 0.17 12.0 0.7 2.7 2 1 0 2 2 2 0 ATP synthase I chain AIRC PF00731.15 EPA05567.1 - 5.3e-20 71.2 4.4 9.2e-20 70.4 3.1 1.4 1 0 0 1 1 1 1 AIR carboxylase NAD_kinase PF01513.16 EPA05567.1 - 0.015 14.0 0.1 0.027 13.2 0.1 1.6 1 1 0 1 1 1 0 ATP-NAD kinase RNA_pol_N PF01194.12 EPA05568.1 - 9e-30 102.4 0.4 1.1e-29 102.1 0.3 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit PhaP_Bmeg PF09602.5 EPA05568.1 - 0.014 15.2 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) tRNA-synt_2 PF00152.15 EPA05568.1 - 0.043 12.5 0.0 0.049 12.3 0.0 1.0 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) Chordopox_RPO7 PF05864.7 EPA05568.1 - 0.18 11.9 1.4 0.63 10.1 0.9 1.8 1 1 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Cu-oxidase_3 PF07732.10 EPA05569.1 - 3.2e-23 81.6 6.1 3.2e-20 72.0 0.5 2.5 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 EPA05569.1 - 5.1e-20 71.3 10.7 3.8e-09 36.1 0.2 3.3 2 1 0 2 2 2 2 Multicopper oxidase TSP_3 PF02412.13 EPA05570.1 - 2.7e-05 23.5 4.4 2.7e-05 23.5 3.1 2.1 2 0 0 2 2 2 2 Thrombospondin type 3 repeat Lactamase_B PF00753.22 EPA05572.1 - 2.8e-28 98.9 2.3 3.4e-28 98.6 1.6 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EPA05572.1 - 1.4e-06 27.9 1.2 2.3e-06 27.2 0.8 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DUF1776 PF08643.5 EPA05572.1 - 0.045 12.8 0.0 0.11 11.6 0.0 1.6 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) S4 PF01479.20 EPA05573.1 - 1.2e-10 40.6 0.1 3.9e-10 39.0 0.0 1.9 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.14 EPA05573.1 - 9.6e-06 25.9 2.1 1.1e-05 25.7 0.9 1.6 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain DUF111 PF01969.12 EPA05574.1 - 1.2e-108 363.3 1.7 1.4e-108 363.1 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF111 DUF1366 PF07104.6 EPA05575.1 - 0.054 13.1 0.3 0.088 12.4 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1366) Ribosomal_S13 PF00416.17 EPA05576.1 - 2.2e-27 95.6 0.0 2.7e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 HHH_6 PF14579.1 EPA05576.1 - 0.029 14.4 0.0 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif UBACT PF02134.16 EPA05577.1 - 0.17 11.4 1.0 0.23 11.0 0.7 1.3 1 1 0 1 1 1 0 Repeat in ubiquitin-activating (UBA) protein DBI_PRT PF02277.12 EPA05578.1 - 2.7e-26 92.4 0.2 4.1e-26 91.8 0.2 1.2 1 0 0 1 1 1 1 Phosphoribosyltransferase QueC PF06508.8 EPA05579.1 - 7.7e-09 35.1 0.4 4.9e-08 32.5 0.1 2.2 2 1 0 2 2 2 1 Queuosine biosynthesis protein QueC NAD_synthase PF02540.12 EPA05579.1 - 1.3e-08 34.0 0.0 2e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 NAD synthase ATP_bind_3 PF01171.15 EPA05579.1 - 1.4e-08 34.4 0.1 1.4e-07 31.1 0.1 2.1 1 1 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.11 EPA05579.1 - 8.3e-08 31.1 0.3 9.4e-07 27.7 0.1 2.1 2 0 0 2 2 2 1 tRNA methyl transferase Asn_synthase PF00733.16 EPA05579.1 - 4.1e-07 29.7 0.0 5.7e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.9 EPA05579.1 - 9.4e-05 21.9 0.1 0.00022 20.7 0.1 1.6 1 1 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.14 EPA05579.1 - 0.035 13.1 0.2 0.074 12.0 0.1 1.6 2 0 0 2 2 2 0 Arginosuccinate synthase Ldh_1_N PF00056.18 EPA05580.1 - 4.5e-36 123.7 0.4 4.5e-36 123.7 0.3 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 EPA05580.1 - 4.4e-30 104.6 0.1 7.5e-30 103.9 0.0 1.4 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.11 EPA05580.1 - 0.12 11.7 1.1 0.54 9.5 0.1 2.2 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase Zip PF02535.17 EPA05581.1 - 1.3e-08 34.1 17.7 1.3e-08 34.1 12.2 2.3 1 1 1 2 2 2 2 ZIP Zinc transporter A2M_N PF01835.14 EPA05583.1 - 0.00022 21.3 0.5 0.016 15.4 0.0 4.2 5 0 0 5 5 5 1 MG2 domain DUF3273 PF11677.3 EPA05583.1 - 0.044 13.0 0.4 0.08 12.1 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3273) HTH_10 PF04967.7 EPA05583.1 - 0.1 12.2 0.1 21 4.8 0.0 2.5 2 0 0 2 2 2 0 HTH DNA binding domain Tachystatin_B PF11478.3 EPA05583.1 - 0.17 11.6 0.3 0.35 10.6 0.2 1.4 1 0 0 1 1 1 0 Antimicrobial chitin binding protein tachystatin B Enolase_C PF00113.17 EPA05585.1 - 4.4e-57 193.3 0.1 6.1e-57 192.8 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 EPA05585.1 - 1.2e-26 93.2 0.0 2.9e-26 91.9 0.0 1.7 1 0 0 1 1 1 1 Enolase, N-terminal domain CW_binding_2 PF04122.7 EPA05585.1 - 0.00044 20.3 2.2 0.001 19.2 0.3 2.4 3 0 0 3 3 3 1 Putative cell wall binding repeat 2 GHMP_kinases_N PF00288.21 EPA05586.1 - 2.3e-20 72.4 0.3 3.7e-20 71.7 0.2 1.3 1 0 0 1 1 1 1 GHMP kinases N terminal domain DUF573 PF04504.9 EPA05586.1 - 0.0045 17.2 0.7 0.0086 16.3 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF573 tRNA_int_endo PF01974.12 EPA05586.1 - 0.059 13.1 0.5 15 5.4 0.0 2.5 3 0 0 3 3 3 0 tRNA intron endonuclease, catalytic C-terminal domain I_LWEQ PF01608.12 EPA05586.1 - 0.07 13.0 0.9 0.12 12.3 0.7 1.5 1 1 0 1 1 1 0 I/LWEQ domain Tubulin_C PF03953.12 EPA05586.1 - 0.17 11.9 0.9 1.6 8.7 0.0 2.5 3 0 0 3 3 3 0 Tubulin C-terminal domain SIS PF01380.17 EPA05587.1 - 4.8e-51 171.7 4.2 9.7e-28 96.3 2.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.1 EPA05587.1 - 1.4e-24 86.5 0.1 5.9e-24 84.5 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_2 PF00310.16 EPA05587.1 - 1.3e-19 70.1 0.0 1.1e-15 57.2 0.0 2.4 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_7 PF13537.1 EPA05587.1 - 2.4e-18 66.0 0.7 1.1e-17 63.9 0.0 2.4 3 0 0 3 3 3 1 Glutamine amidotransferase domain GATase_4 PF13230.1 EPA05587.1 - 4.2e-08 32.2 0.2 7.6e-08 31.3 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.1 EPA05587.1 - 1.5e-06 28.0 7.9 0.0006 19.5 0.5 4.3 3 1 1 4 4 4 2 SIS domain eIF-1a PF01176.14 EPA05587.1 - 0.08 12.3 0.1 5.2 6.5 0.0 2.6 2 0 0 2 2 2 0 Translation initiation factor 1A / IF-1 Memo PF01875.12 EPA05588.1 - 7.7e-82 274.2 0.0 8.6e-82 274.0 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein LigB PF02900.13 EPA05588.1 - 0.00057 18.9 0.0 0.00072 18.6 0.0 1.2 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Radical_SAM PF04055.16 EPA05589.1 - 6.4e-09 36.2 0.0 1.4e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily B12-binding PF02310.14 EPA05589.1 - 0.018 14.8 0.0 0.094 12.5 0.1 2.1 2 1 0 2 2 2 0 B12 binding domain polyprenyl_synt PF00348.12 EPA05590.1 - 1.3e-69 233.9 0.4 1.6e-69 233.6 0.3 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Terpene_synth_C PF03936.11 EPA05590.1 - 0.00025 20.3 0.0 0.00052 19.3 0.0 1.5 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain GHMP_kinases_C PF08544.8 EPA05591.1 - 2.7e-14 53.1 0.1 3.2e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 GHMP kinases C terminal Aminotran_5 PF00266.14 EPA05592.1 - 4.2e-94 315.3 0.0 4.9e-94 315.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 EPA05592.1 - 4.7e-07 29.2 0.0 9.5e-07 28.2 0.0 1.3 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 EPA05592.1 - 2.7e-05 23.3 0.0 6.5e-05 22.1 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 EPA05592.1 - 0.0053 15.0 0.0 0.0078 14.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Pyridoxal_deC PF00282.14 EPA05592.1 - 0.038 12.4 0.0 0.078 11.4 0.0 1.5 2 0 0 2 2 2 0 Pyridoxal-dependent decarboxylase conserved domain YjeF_N PF03853.10 EPA05593.1 - 2.6e-48 163.8 0.0 3e-48 163.6 0.0 1.0 1 0 0 1 1 1 1 YjeF-related protein N-terminus CxxCxxCC PF03692.10 EPA05594.1 - 6.6e-09 36.1 0.4 1.2e-08 35.2 0.3 1.4 1 0 0 1 1 1 1 Putative zinc- or iron-chelating domain DUF2054 PF10218.4 EPA05594.1 - 0.093 12.5 2.4 7.9 6.3 1.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2054) DUF3352 PF11832.3 EPA05594.1 - 0.16 10.2 0.0 0.21 9.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3352) DUF4376 PF14301.1 EPA05596.1 - 0.02 15.0 0.1 0.021 14.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4376) TMEM51 PF15345.1 EPA05597.1 - 8.8e-06 25.5 0.2 9.6e-06 25.4 0.1 1.0 1 0 0 1 1 1 1 Transmembrane protein 51 Rnf-Nqr PF02508.9 EPA05597.1 - 0.016 14.8 0.2 0.029 13.9 0.0 1.4 1 1 0 1 1 1 0 Rnf-Nqr subunit, membrane protein DUF4345 PF14248.1 EPA05597.1 - 0.024 14.0 0.1 0.036 13.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4345) Tetraspannin PF00335.15 EPA05597.1 - 0.07 12.4 1.7 0.091 12.0 1.2 1.1 1 0 0 1 1 1 0 Tetraspanin family DUF2910 PF11139.3 EPA05597.1 - 0.083 12.0 0.1 0.11 11.5 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2910) DUF2929 PF11151.3 EPA05597.1 - 0.083 12.9 2.5 3.7 7.6 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2929) Glycophorin_A PF01102.13 EPA05597.1 - 0.11 12.2 0.1 0.11 12.2 0.0 2.0 1 1 0 2 2 2 0 Glycophorin A DUF2964 PF11177.3 EPA05597.1 - 0.13 12.2 0.8 0.13 12.2 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2964) DUF4064 PF13273.1 EPA05597.1 - 0.21 11.6 7.9 1.4 9.0 5.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) Syndecan PF01034.15 EPA05597.1 - 0.4 10.3 3.7 18 5.0 2.0 2.2 2 0 0 2 2 2 0 Syndecan domain DUF4097 PF13349.1 EPA05597.1 - 0.73 9.3 8.2 2.2 7.8 2.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4097) AA_permease_2 PF13520.1 EPA05597.1 - 0.85 8.0 3.3 1.1 7.7 2.3 1.0 1 0 0 1 1 1 0 Amino acid permease DUF3917 PF13055.1 EPA05597.1 - 3 8.1 6.0 0.79 10.0 1.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3917) DUF3188 PF11384.3 EPA05597.1 - 4.3 6.9 6.5 2.2 7.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3188) DUF3185 PF11381.3 EPA05597.1 - 6.3 6.6 8.3 1.6 8.5 2.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) HTH_AsnC-type PF13404.1 EPA05598.1 - 2.3e-12 46.2 1.5 3.7e-12 45.5 1.0 1.3 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.1 EPA05598.1 - 2.5e-12 45.9 4.6 2.9e-12 45.7 2.0 2.0 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.16 EPA05598.1 - 1.6e-11 43.7 0.1 2.6e-11 43.0 0.1 1.3 1 0 0 1 1 1 1 AsnC family HTH_11 PF08279.7 EPA05598.1 - 1e-05 25.0 0.5 1e-05 25.0 0.4 1.9 2 0 0 2 2 2 1 HTH domain HTH_Crp_2 PF13545.1 EPA05598.1 - 0.00096 18.9 0.1 0.0024 17.6 0.1 1.6 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_20 PF12840.2 EPA05598.1 - 0.0016 18.2 0.0 0.0028 17.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.2 EPA05598.1 - 0.0052 16.4 0.1 0.0079 15.8 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_10 PF04967.7 EPA05598.1 - 0.0061 16.1 0.3 0.016 14.8 0.2 1.7 1 0 0 1 1 1 1 HTH DNA binding domain DDRGK PF09756.4 EPA05598.1 - 0.0063 15.9 0.5 0.012 15.0 0.1 1.6 1 1 0 1 1 1 1 DDRGK domain NUMOD1 PF07453.8 EPA05598.1 - 0.0092 15.7 0.2 2.2 8.2 0.0 2.6 2 0 0 2 2 2 1 NUMOD1 domain TrmB PF01978.14 EPA05598.1 - 0.021 14.4 0.2 0.04 13.6 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF294_C PF10335.4 EPA05598.1 - 0.023 14.3 0.0 0.037 13.6 0.0 1.5 1 0 0 1 1 1 0 Putative nucleotidyltransferase substrate binding domain UPF0302 PF08864.5 EPA05598.1 - 0.024 14.4 0.1 0.049 13.4 0.1 1.6 1 1 0 1 1 1 0 UPF0302 domain RepL PF05732.6 EPA05598.1 - 0.032 13.4 1.0 0.048 12.8 0.1 1.6 2 0 0 2 2 2 0 Firmicute plasmid replication protein (RepL) GntR PF00392.16 EPA05598.1 - 0.04 13.3 0.2 0.064 12.6 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_23 PF13384.1 EPA05598.1 - 0.041 13.5 0.1 0.081 12.6 0.1 1.5 1 0 0 1 1 1 0 Homeodomain-like domain MarR PF01047.17 EPA05598.1 - 0.061 13.0 0.3 0.12 12.0 0.2 1.5 1 0 0 1 1 1 0 MarR family HTH_28 PF13518.1 EPA05598.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_3 PF01381.17 EPA05598.1 - 0.15 11.8 1.9 0.6 9.9 0.1 2.7 3 1 0 3 3 3 0 Helix-turn-helix HTH_26 PF13443.1 EPA05598.1 - 0.18 12.0 1.0 0.44 10.7 0.3 1.9 2 0 0 2 2 1 0 Cro/C1-type HTH DNA-binding domain DUF603 PF04645.7 EPA05598.1 - 0.19 11.6 2.7 1.8 8.4 0.0 2.6 1 1 1 3 3 3 0 Protein of unknown function, DUF603 HTH_19 PF12844.2 EPA05598.1 - 0.23 11.5 0.3 0.23 11.5 0.2 2.6 2 1 0 2 2 2 0 Helix-turn-helix domain Sec3_C_2 PF15278.1 EPA05599.1 - 0.011 15.7 0.4 0.011 15.7 0.3 1.0 1 0 0 1 1 1 0 Sec3 exocyst complex subunit TcdB_N PF12918.2 EPA05599.1 - 0.026 14.5 2.4 0.031 14.3 1.6 1.1 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain DUF2630 PF10944.3 EPA05599.1 - 0.071 13.2 0.1 0.093 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2630) WIYLD PF10440.4 EPA05599.1 - 0.11 12.4 0.1 0.13 12.2 0.1 1.1 1 0 0 1 1 1 0 Ubiquitin-binding WIYLD domain DUF1825 PF08855.5 EPA05599.1 - 0.12 12.4 0.5 0.14 12.1 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1825) DUF1025 PF06262.6 EPA05601.1 - 0.02 14.6 4.8 0.24 11.1 0.0 3.0 3 0 0 3 3 3 0 Possibl zinc metallo-peptidase zf-ribbon_3 PF13248.1 EPA05603.1 - 0.018 14.2 1.0 0.03 13.5 0.0 1.9 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.7 EPA05603.1 - 0.42 9.9 4.2 0.55 9.5 0.1 2.8 3 1 0 3 3 3 0 TFIIB zinc-binding CARDB PF07705.6 EPA05604.1 - 0.047 13.7 0.2 0.071 13.1 0.2 1.3 1 0 0 1 1 1 0 CARDB DUF1425 PF07233.7 EPA05604.1 - 0.057 12.9 0.2 0.081 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1425) Sec2p PF06428.6 EPA05605.1 - 0.033 14.0 1.3 0.033 14.0 0.9 1.5 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p ATP-synt_E_2 PF08112.6 EPA05605.1 - 0.043 13.8 6.2 0.065 13.3 4.3 1.3 1 0 0 1 1 1 0 ATP synthase epsilon subunit Ribosomal_S13 PF00416.17 EPA05605.1 - 0.76 10.2 2.8 0.98 9.9 2.0 1.4 1 1 0 1 1 1 0 Ribosomal protein S13/S18 VitK2_biosynth PF02621.9 EPA05606.1 - 2.3e-72 243.2 0.0 2.6e-72 243.0 0.0 1.0 1 0 0 1 1 1 1 Menaquinone biosynthesis YhfZ_C PF14503.1 EPA05606.1 - 0.056 12.7 0.0 0.097 12.0 0.0 1.3 1 0 0 1 1 1 0 YhfZ C-terminal domain HD PF01966.17 EPA05607.1 - 0.0089 16.0 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 HD domain COG2 PF06148.6 EPA05609.1 - 0.042 13.7 6.1 0.043 13.7 4.2 1.1 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Lipoprotein_20 PF13942.1 EPA05609.1 - 0.055 13.0 6.7 0.06 12.8 4.6 1.1 1 0 0 1 1 1 0 YfhG lipoprotein YliH PF10799.3 EPA05609.1 - 0.063 12.9 1.1 0.066 12.9 0.7 1.0 1 0 0 1 1 1 0 Biofilm formation protein (YliH/bssR) DUF1845 PF08900.6 EPA05609.1 - 0.3 10.3 3.3 0.32 10.2 2.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1845) bZIP_Maf PF03131.12 EPA05609.1 - 1.4 9.2 8.7 2.2 8.6 6.0 1.3 1 1 0 1 1 1 0 bZIP Maf transcription factor SieB PF14163.1 EPA05609.1 - 1.5 8.3 7.4 1.5 8.3 5.1 1.1 1 0 0 1 1 1 0 Superinfection exclusion protein B Nup88 PF10168.4 EPA05609.1 - 1.7 6.4 11.1 1.8 6.3 7.7 1.0 1 0 0 1 1 1 0 Nuclear pore component YfhO PF09586.5 EPA05609.1 - 2 6.3 4.5 2.1 6.2 3.1 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO MscS_TM PF12794.2 EPA05609.1 - 2.3 6.7 6.2 2.7 6.5 4.3 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF4225 PF13988.1 EPA05609.1 - 3.9 6.8 5.3 5.2 6.5 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4225) ACCA PF03255.9 EPA05609.1 - 5.8 6.4 8.7 6.2 6.3 6.0 1.1 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit GLE1 PF07817.8 EPA05609.1 - 6.2 5.6 12.5 7.1 5.4 8.7 1.1 1 0 0 1 1 1 0 GLE1-like protein Tnp_P_element PF12017.3 EPA05609.1 - 6.3 5.9 8.2 6.8 5.8 5.7 1.1 1 0 0 1 1 1 0 Transposase protein Vfa1 PF08432.5 EPA05609.1 - 9.1 6.2 16.8 9.5 6.1 11.6 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 MSV199 PF10553.4 EPA05609.1 - 9.3 6.1 15.1 11 5.9 10.5 1.0 1 0 0 1 1 1 0 MSV199 domain zf-ribbon_3 PF13248.1 EPA05610.1 - 0.00037 19.5 0.8 0.72 9.1 0.0 2.3 2 0 0 2 2 2 2 zinc-ribbon domain zf-ISL3 PF14690.1 EPA05610.1 - 0.0037 17.2 0.5 1.9 8.5 0.0 2.4 2 0 0 2 2 2 2 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zinc_ribbon_2 PF13240.1 EPA05610.1 - 0.025 14.0 2.7 3.3 7.3 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 EPA05610.1 - 0.036 14.0 0.3 2.3 8.2 0.0 2.5 2 0 0 2 2 2 0 Zinc ribbon domain DNA_RNApol_7kD PF03604.8 EPA05610.1 - 0.077 12.4 1.0 0.21 11.0 0.1 2.1 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-RING_4 PF14570.1 EPA05610.1 - 0.095 12.3 9.0 0.38 10.3 6.4 1.8 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain DZR PF12773.2 EPA05610.1 - 0.39 10.5 5.1 1.3 8.8 3.5 1.8 1 1 0 1 1 1 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.6 EPA05610.1 - 1.2 8.8 3.7 2.8 7.6 2.4 1.6 1 1 1 2 2 2 0 Putative transposase DNA-binding domain C1_1 PF00130.17 EPA05610.1 - 1.5 8.5 6.9 2.7 7.7 4.8 1.4 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Flagellar_rod PF05149.7 EPA05611.1 - 0.00062 19.0 4.6 0.00068 18.9 3.2 1.0 1 0 0 1 1 1 1 Paraflagellar rod protein DUF812 PF05667.6 EPA05611.1 - 0.0008 18.0 4.8 0.00088 17.8 3.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) GAS PF13851.1 EPA05611.1 - 0.0058 15.8 5.3 0.0068 15.6 3.7 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding IL4 PF00727.13 EPA05611.1 - 0.0071 16.2 0.2 0.0082 15.9 0.2 1.2 1 0 0 1 1 1 1 Interleukin 4 APG6 PF04111.7 EPA05611.1 - 0.012 14.6 4.6 0.013 14.5 3.2 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 Tektin PF03148.9 EPA05611.1 - 0.012 14.1 2.5 0.015 13.8 1.7 1.2 1 0 0 1 1 1 0 Tektin family DUF724 PF05266.9 EPA05611.1 - 0.013 15.0 2.9 0.016 14.8 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4472 PF14739.1 EPA05611.1 - 0.024 15.0 3.3 0.03 14.7 2.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) TMF_TATA_bd PF12325.3 EPA05611.1 - 0.027 14.1 7.2 0.059 13.1 5.0 1.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding COG6 PF06419.6 EPA05611.1 - 0.029 12.5 3.2 0.03 12.4 2.2 1.0 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 AAA_13 PF13166.1 EPA05611.1 - 0.031 12.7 4.1 0.034 12.6 2.9 1.0 1 0 0 1 1 1 0 AAA domain Laminin_II PF06009.7 EPA05611.1 - 0.035 13.8 3.1 0.037 13.7 2.2 1.1 1 0 0 1 1 1 0 Laminin Domain II Vac_Fusion PF02346.11 EPA05611.1 - 0.039 13.3 5.2 1.3 8.5 2.8 2.2 1 1 1 2 2 2 0 Chordopoxvirus fusion protein ADIP PF11559.3 EPA05611.1 - 0.045 13.6 4.6 0.049 13.5 3.2 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding IncA PF04156.9 EPA05611.1 - 0.052 13.1 4.8 0.052 13.1 3.3 1.0 1 0 0 1 1 1 0 IncA protein BLOC1_2 PF10046.4 EPA05611.1 - 0.052 13.6 4.2 0.12 12.5 0.4 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Mnd1 PF03962.10 EPA05611.1 - 0.058 13.0 4.1 0.068 12.8 2.8 1.0 1 0 0 1 1 1 0 Mnd1 family DUF1664 PF07889.7 EPA05611.1 - 0.076 12.8 3.0 0.21 11.3 2.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.4 EPA05611.1 - 0.079 12.8 6.5 0.099 12.4 4.5 1.1 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EMP24_GP25L PF01105.19 EPA05611.1 - 0.083 12.5 2.7 0.13 11.9 1.8 1.4 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DivIC PF04977.10 EPA05611.1 - 0.084 12.3 7.3 1.7 8.2 1.0 2.1 1 1 1 2 2 2 0 Septum formation initiator CCDC-167 PF15188.1 EPA05611.1 - 0.1 12.5 5.9 0.12 12.3 4.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Fmp27_WPPW PF10359.4 EPA05611.1 - 0.11 10.9 4.2 0.12 10.8 2.9 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain STAT_alpha PF01017.15 EPA05611.1 - 0.11 12.2 2.8 0.28 10.8 1.9 1.7 1 1 0 1 1 1 0 STAT protein, all-alpha domain ATG16 PF08614.6 EPA05611.1 - 0.11 12.2 5.6 0.11 12.2 3.9 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Snapin_Pallidin PF14712.1 EPA05611.1 - 0.12 12.7 3.8 2.6 8.4 0.2 2.0 1 1 1 2 2 2 0 Snapin/Pallidin V_ATPase_I PF01496.14 EPA05611.1 - 0.13 10.1 4.4 0.14 10.0 3.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Allexi_40kDa PF05549.6 EPA05611.1 - 0.14 11.3 2.4 0.18 11.0 1.6 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein Spc7 PF08317.6 EPA05611.1 - 0.15 10.7 5.2 0.15 10.6 3.6 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein TMF_DNA_bd PF12329.3 EPA05611.1 - 0.19 11.5 7.9 0.31 10.8 5.5 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.7 EPA05611.1 - 0.22 11.9 3.5 1.6 9.1 2.4 2.0 1 1 0 1 1 1 0 SlyX Nup88 PF10168.4 EPA05611.1 - 0.22 9.3 5.5 0.24 9.1 3.8 1.0 1 0 0 1 1 1 0 Nuclear pore component Spore_II_R PF09551.5 EPA05611.1 - 0.23 11.5 1.9 0.25 11.3 1.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) TBPIP PF07106.8 EPA05611.1 - 0.25 10.8 5.4 0.32 10.5 3.8 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Bacillus_HBL PF05791.6 EPA05611.1 - 0.27 10.5 2.4 0.28 10.5 1.6 1.1 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) XhlA PF10779.4 EPA05611.1 - 0.33 10.8 9.5 0.31 10.9 2.8 2.1 1 1 1 2 2 2 0 Haemolysin XhlA Ax_dynein_light PF10211.4 EPA05611.1 - 0.35 10.6 5.1 0.43 10.4 3.5 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain DUF342 PF03961.8 EPA05611.1 - 0.36 9.1 4.5 0.37 9.1 3.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF4200 PF13863.1 EPA05611.1 - 0.39 10.6 7.0 0.48 10.3 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Prefoldin_2 PF01920.15 EPA05611.1 - 0.41 10.4 7.7 0.41 10.4 1.0 2.0 1 1 1 2 2 2 0 Prefoldin subunit TMPIT PF07851.8 EPA05611.1 - 0.44 9.5 2.8 0.46 9.4 2.0 1.0 1 0 0 1 1 1 0 TMPIT-like protein Tropomyosin_1 PF12718.2 EPA05611.1 - 0.45 10.3 7.4 0.41 10.4 2.7 1.7 1 1 1 2 2 2 0 Tropomyosin like DUF972 PF06156.8 EPA05611.1 - 0.56 10.5 3.5 0.68 10.3 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Fib_alpha PF08702.5 EPA05611.1 - 0.61 10.2 3.4 5.2 7.1 0.1 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family PRP1_N PF06424.7 EPA05611.1 - 0.62 10.3 3.0 0.66 10.2 2.1 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Matrilin_ccoil PF10393.4 EPA05611.1 - 1.5 8.2 4.5 7.7 5.9 0.1 2.3 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF3847 PF12958.2 EPA05611.1 - 2.1 8.1 8.0 1.3 8.8 2.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3847) IFP_35_N PF07334.8 EPA05611.1 - 5 7.1 6.6 4.4 7.3 0.4 2.1 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus TrkH PF02386.11 EPA05612.1 - 5.3e-26 91.0 40.1 1.7e-24 86.0 6.5 3.8 1 1 3 4 4 4 3 Cation transport protein CBS PF00571.23 EPA05612.1 - 5.3e-20 70.9 2.9 5.6e-12 45.2 0.1 2.6 2 0 0 2 2 2 2 CBS domain GTP_EFTU PF00009.22 EPA05615.1 - 2e-56 190.4 0.5 3.2e-56 189.7 0.3 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 EPA05615.1 - 1.1e-27 95.9 0.0 3.9e-27 94.1 0.0 2.0 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.1 EPA05615.1 - 8.1e-21 73.6 0.6 1.9e-20 72.4 0.4 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 EPA05615.1 - 1e-19 70.1 0.0 3.4e-19 68.4 0.0 2.0 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EPA05615.1 - 4.7e-14 52.2 0.1 2.2e-13 50.1 0.1 2.3 1 0 0 1 1 1 1 Elongation factor Tu domain 2 TPR_1 PF00515.23 EPA05616.1 - 2.6e-23 80.6 8.3 1.7e-06 27.3 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 EPA05616.1 - 1.6e-22 78.8 3.4 5.2e-13 48.4 0.6 2.2 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 EPA05616.1 - 3.1e-21 73.5 3.9 4.5e-05 23.0 0.1 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.1 EPA05616.1 - 3.2e-15 56.3 0.0 6.6e-09 36.2 0.0 2.5 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 EPA05616.1 - 7.9e-13 47.1 6.4 0.0014 18.2 0.0 3.7 4 0 0 4 4 3 3 Tetratricopeptide repeat Apc3 PF12895.2 EPA05616.1 - 1.2e-12 47.7 5.1 4.5e-07 29.9 0.2 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 EPA05616.1 - 2.5e-12 45.9 2.5 0.021 14.9 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 EPA05616.1 - 5.5e-12 45.4 2.5 2.1e-06 27.5 0.3 2.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 EPA05616.1 - 8.8e-11 41.4 0.0 0.02 15.4 0.0 4.0 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 EPA05616.1 - 5.3e-09 36.2 1.4 7.8e-05 22.9 0.1 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 EPA05616.1 - 4.3e-08 32.3 0.4 0.033 13.9 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 EPA05616.1 - 2.1e-07 30.7 0.0 0.0031 17.3 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat MIT PF04212.13 EPA05616.1 - 7.3e-07 28.9 1.3 0.48 10.3 0.1 4.2 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_3 PF07720.7 EPA05616.1 - 9.8e-07 28.4 2.8 3e-05 23.6 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EPA05616.1 - 1.1e-06 28.4 0.4 0.61 10.0 0.0 4.1 4 0 0 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 EPA05616.1 - 2.6e-05 24.3 0.5 0.41 11.1 0.0 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat DUF3856 PF12968.2 EPA05616.1 - 0.0011 18.7 0.0 5.9 6.7 0.0 3.2 1 1 2 3 3 3 2 Domain of Unknown Function (DUF3856) DUF627 PF04781.7 EPA05616.1 - 0.015 14.9 1.5 10 5.8 0.1 3.4 1 1 3 4 4 4 0 Protein of unknown function (DUF627) MerR_2 PF13591.1 EPA05616.1 - 0.046 13.3 0.1 0.16 11.6 0.0 1.9 2 0 0 2 2 2 0 MerR HTH family regulatory protein TPR_10 PF13374.1 EPA05616.1 - 0.053 13.4 0.0 2.7 8.0 0.0 2.8 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_5 PF12688.2 EPA05616.1 - 0.063 13.3 0.1 8 6.5 0.0 2.4 1 1 1 2 2 2 0 Tetratrico peptide repeat PPR PF01535.15 EPA05616.1 - 0.11 12.4 0.2 7.4 6.7 0.1 2.8 2 0 0 2 2 2 0 PPR repeat SIS PF01380.17 EPA05617.1 - 1.7e-08 34.1 3.6 3.6e-06 26.6 0.0 3.1 2 1 0 2 2 2 2 SIS domain zf-C2H2_2 PF12756.2 EPA05618.1 - 0.026 14.6 1.0 0.029 14.4 0.7 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.1 EPA05618.1 - 0.061 13.6 2.1 0.15 12.4 1.5 1.7 1 1 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 EPA05618.1 - 0.18 12.1 2.0 0.33 11.3 0.6 1.8 1 1 1 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 EPA05618.1 - 0.38 10.9 4.2 0.43 10.7 0.5 2.1 1 1 1 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF2045 PF09741.4 EPA05619.1 - 0.04 13.0 0.2 0.044 12.9 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2045) Pox_A3L PF05288.6 EPA05619.1 - 0.1 12.3 1.1 0.17 11.6 0.7 1.4 1 0 0 1 1 1 0 Poxvirus A3L Protein CagY_M PF07337.6 EPA05619.1 - 0.41 10.1 8.8 0.49 9.9 0.3 3.6 2 1 1 3 3 3 0 DC-EC Repeat Usp PF00582.21 EPA05620.1 - 3.3e-28 98.6 0.0 4.1e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family GARS_N PF02844.10 EPA05620.1 - 0.00038 20.8 0.2 0.00068 20.0 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain SRP54 PF00448.17 EPA05620.1 - 0.046 13.1 0.0 0.06 12.7 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Glyco_hydro_97 PF10566.4 EPA05620.1 - 0.24 10.4 0.9 2.6 7.0 0.6 2.0 1 1 0 1 1 1 0 Glycoside hydrolase 97 TFIIB PF00382.14 EPA05621.1 - 4.7e-32 109.6 6.5 7.2e-18 64.1 0.3 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EPA05621.1 - 3.2e-10 39.1 1.1 5.6e-10 38.3 0.7 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.14 EPA05621.1 - 0.00051 19.9 0.0 0.37 10.7 0.0 2.4 2 0 0 2 2 2 2 Cyclin, C-terminal domain zf-ribbon_3 PF13248.1 EPA05621.1 - 0.0012 17.9 1.2 0.0024 17.0 0.8 1.6 1 0 0 1 1 1 1 zinc-ribbon domain Cyclin_N PF00134.18 EPA05621.1 - 0.0017 17.9 0.7 0.05 13.1 0.1 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Sigma70_r4 PF04545.11 EPA05621.1 - 0.005 16.1 0.0 0.39 10.0 0.0 3.4 3 1 1 4 4 4 1 Sigma-70, region 4 HTH_11 PF08279.7 EPA05621.1 - 0.0056 16.3 1.2 0.048 13.3 0.0 2.7 3 0 0 3 3 3 1 HTH domain HTH_AsnC-type PF13404.1 EPA05621.1 - 0.01 15.3 0.0 0.3 10.6 0.0 3.0 3 0 0 3 3 3 0 AsnC-type helix-turn-helix domain HTH_23 PF13384.1 EPA05621.1 - 0.12 12.0 2.1 0.9 9.2 0.0 3.1 3 1 0 3 3 3 0 Homeodomain-like domain Sigma70_r4_2 PF08281.7 EPA05621.1 - 0.16 11.4 1.5 4.4 6.8 0.0 3.2 3 0 0 3 3 3 0 Sigma-70, region 4 Peptidase_M13_N PF05649.8 EPA05621.1 - 0.33 9.9 2.1 0.47 9.4 0.4 1.9 2 1 0 2 2 2 0 Peptidase family M13 zf-NADH-PPase PF09297.6 EPA05621.1 - 0.42 10.1 2.9 0.65 9.5 0.1 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.1 EPA05621.1 - 0.64 9.5 3.3 1.4 8.4 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Radical_SAM PF04055.16 EPA05622.1 - 2.6e-17 63.4 0.1 6.7e-17 62.1 0.0 1.7 1 1 1 2 2 2 1 Radical SAM superfamily Fer4_14 PF13394.1 EPA05622.1 - 0.019 14.9 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain Auto_anti-p27 PF06677.7 EPA05623.1 - 0.095 12.4 1.8 0.19 11.5 0.1 2.0 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) VP_N-CPKC PF11475.3 EPA05623.1 - 0.097 12.2 0.4 0.42 10.1 0.0 1.9 2 0 0 2 2 2 0 Virion protein N terminal domain GFA PF04828.9 EPA05623.1 - 0.17 11.8 1.7 0.84 9.6 1.2 1.8 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme zf-C3HC4_3 PF13920.1 EPA05623.1 - 1.1 9.0 4.1 4.4 7.0 2.8 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_5 PF13719.1 EPA05623.1 - 2.2 7.9 4.5 14 5.3 3.1 2.0 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA05623.1 - 2.2 8.0 4.5 16 5.3 3.1 2.0 1 1 0 1 1 1 0 zinc-ribbon domain zf-CCHC_5 PF14787.1 EPA05623.1 - 3.3 7.2 6.4 9.1 5.8 0.1 2.5 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger DnaJ PF00226.26 EPA05624.1 - 5.4e-22 77.3 6.6 5.4e-22 77.3 4.6 1.8 2 0 0 2 2 2 1 DnaJ domain CD20 PF04103.10 EPA05624.1 - 0.11 12.4 0.1 0.35 10.8 0.0 1.8 1 1 0 1 1 1 0 CD20-like family YMF19 PF02326.10 EPA05624.1 - 1.2 9.8 3.4 8.8 6.9 0.1 2.3 1 1 1 2 2 2 0 Plant ATP synthase F0 TPR_1 PF00515.23 EPA05625.1 - 5.8e-16 57.3 0.1 3.2e-09 35.9 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 EPA05625.1 - 5.8e-15 54.7 0.0 6.2e-15 54.5 0.0 1.0 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.12 EPA05625.1 - 7.4e-15 53.6 0.1 5e-08 32.2 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 EPA05625.1 - 1.1e-10 40.5 0.1 4.4e-07 29.2 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 EPA05625.1 - 1.1e-09 38.7 0.0 1.3e-09 38.4 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.1 EPA05625.1 - 1.8e-08 34.0 0.1 2e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.1 EPA05625.1 - 2.9e-08 32.8 0.0 0.00015 21.3 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 EPA05625.1 - 1.2e-07 31.9 0.0 1.4e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.1 EPA05625.1 - 1.5e-07 31.3 0.1 0.0033 17.9 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 EPA05625.1 - 4.4e-07 29.7 0.1 2.2e-06 27.4 0.1 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.1 EPA05625.1 - 5.8e-07 29.2 0.2 3.6e-06 26.7 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 EPA05625.1 - 0.0017 18.4 0.0 0.0021 18.1 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.3 EPA05625.1 - 0.0058 15.4 0.0 0.0063 15.3 0.0 1.0 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 TPR_10 PF13374.1 EPA05625.1 - 0.014 15.3 0.0 0.52 10.3 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.2 EPA05625.1 - 0.016 14.9 0.0 0.019 14.7 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) MIT PF04212.13 EPA05625.1 - 0.042 13.7 0.0 1.6 8.6 0.0 2.1 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 EPA05625.1 - 0.043 14.2 0.0 1.4 9.5 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_5 PF12688.2 EPA05625.1 - 0.049 13.6 0.1 0.82 9.7 0.0 1.9 1 1 1 2 2 2 0 Tetratrico peptide repeat Coatomer_E PF04733.9 EPA05625.1 - 0.057 12.6 0.0 0.11 11.6 0.0 1.4 1 1 0 1 1 1 0 Coatomer epsilon subunit Fis1_TPR_C PF14853.1 EPA05625.1 - 0.059 13.2 0.1 0.32 10.9 0.0 2.0 1 1 2 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat PPR PF01535.15 EPA05625.1 - 0.14 12.1 0.2 2 8.5 0.0 2.2 2 0 0 2 2 2 0 PPR repeat DUF561 PF04481.7 EPA05627.1 - 0.071 12.0 0.1 0.072 12.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF561) GATase PF00117.23 EPA05628.1 - 3e-35 121.4 0.0 3.3e-35 121.2 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EPA05628.1 - 4.2e-07 29.6 0.0 4.5e-06 26.2 0.0 2.4 1 1 0 1 1 1 1 Peptidase C26 GATase_3 PF07685.9 EPA05628.1 - 0.00019 21.0 0.0 0.00035 20.1 0.0 1.5 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.14 EPA05628.1 - 0.00026 20.6 0.0 0.0027 17.3 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family His_biosynth PF00977.16 EPA05629.1 - 3.8e-41 140.8 0.2 4.1e-41 140.7 0.1 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.9 EPA05629.1 - 0.088 11.8 0.1 0.78 8.7 0.0 1.9 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG IGPD PF00475.13 EPA05630.1 - 9.3e-29 100.1 0.0 1e-28 99.9 0.0 1.0 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase ANF_receptor PF01094.23 EPA05630.1 - 0.024 13.4 0.0 0.028 13.1 0.0 1.1 1 0 0 1 1 1 0 Receptor family ligand binding region DNase-RNase PF02577.9 EPA05631.1 - 1e-12 47.4 0.0 1.1e-12 47.2 0.0 1.0 1 0 0 1 1 1 1 Bifunctional nuclease HTH_19 PF12844.2 EPA05631.1 - 0.029 14.4 0.2 0.46 10.5 0.0 2.4 2 1 0 2 2 2 0 Helix-turn-helix domain Ribosomal_L7Ae PF01248.21 EPA05631.1 - 0.096 12.2 0.3 0.2 11.1 0.2 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CBS PF00571.23 EPA05633.1 - 3.5e-32 109.9 0.7 1.8e-09 37.2 0.0 4.2 4 0 0 4 4 4 4 CBS domain Lactamase_B_2 PF12706.2 EPA05634.1 - 0.0084 15.6 0.4 1.3 8.4 0.5 2.8 2 1 0 2 2 2 2 Beta-lactamase superfamily domain RMMBL PF07521.7 EPA05634.1 - 0.016 14.9 0.0 0.05 13.4 0.0 1.9 1 0 0 1 1 1 0 RNA-metabolising metallo-beta-lactamase Response_reg PF00072.19 EPA05635.1 - 2.7e-16 59.5 0.1 2.9e-16 59.4 0.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain DUF1188 PF06690.6 EPA05635.1 - 0.036 13.2 0.0 0.037 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) AsnC_trans_reg PF01037.16 EPA05636.1 - 3.9e-11 42.4 0.1 4.3e-11 42.3 0.1 1.0 1 0 0 1 1 1 1 AsnC family RimK PF08443.6 EPA05636.1 - 0.019 14.4 0.2 0.019 14.4 0.2 1.1 1 0 0 1 1 1 0 RimK-like ATP-grasp domain ACT_4 PF13291.1 EPA05636.1 - 0.026 14.8 0.2 4.8 7.5 0.0 2.1 2 0 0 2 2 2 0 ACT domain CARDB PF07705.6 EPA05637.1 - 0.0033 17.4 0.3 0.009 16.0 0.2 1.8 1 0 0 1 1 1 1 CARDB APS_kinase PF01583.15 EPA05638.1 - 2.6e-50 170.1 0.0 3.1e-50 169.8 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.1 EPA05638.1 - 4.2e-08 33.1 0.0 5.5e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EPA05638.1 - 2.5e-06 28.3 0.0 4.4e-06 27.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EPA05638.1 - 1.6e-05 25.2 0.0 3.4e-05 24.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EPA05638.1 - 0.00018 20.6 0.0 0.00028 20.0 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin KTI12 PF08433.5 EPA05638.1 - 0.00045 19.5 0.0 0.00064 19.0 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_28 PF13521.1 EPA05638.1 - 0.034 14.1 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain CPT PF07931.7 EPA05638.1 - 0.04 13.5 0.1 5.2 6.6 0.0 2.3 1 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Arf PF00025.16 EPA05638.1 - 0.098 11.8 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family Ammonium_transp PF00909.16 EPA05641.1 - 1.9e-113 378.9 29.1 2.1e-113 378.8 20.2 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Fer4_14 PF13394.1 EPA05642.1 - 5.3e-16 58.7 1.1 9.3e-16 57.9 0.1 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 EPA05642.1 - 1.2e-14 54.5 0.7 8.4e-14 51.8 0.1 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain Radical_SAM PF04055.16 EPA05642.1 - 1.6e-10 41.4 0.1 2.1e-10 40.9 0.1 1.2 1 0 0 1 1 1 1 Radical SAM superfamily TM1586_NiRdase PF14512.1 EPA05642.1 - 0.078 12.1 0.2 0.3 10.2 0.0 1.9 2 1 0 2 2 2 0 Putative TM nitroreductase Usp PF00582.21 EPA05643.1 - 6.6e-29 100.8 0.0 8.1e-29 100.6 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family DUF1574 PF07611.6 EPA05643.1 - 0.0026 16.6 0.1 0.0034 16.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1574) Utp13 PF08625.6 EPA05643.1 - 0.012 15.2 0.1 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 Utp13 specific WD40 associated domain Bet_v_1 PF00407.14 EPA05643.1 - 0.11 12.0 0.3 0.17 11.5 0.2 1.2 1 0 0 1 1 1 0 Pathogenesis-related protein Bet v I family AP_endonuc_2 PF01261.19 EPA05643.1 - 0.16 11.2 0.0 0.26 10.5 0.0 1.4 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel HSP20 PF00011.16 EPA05644.1 - 8.8e-07 28.7 4.8 1e-05 25.3 3.3 2.0 1 1 0 1 1 1 1 Hsp20/alpha crystallin family PIH1 PF08190.7 EPA05644.1 - 0.016 14.6 0.1 0.018 14.4 0.1 1.1 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 C1_1 PF00130.17 EPA05645.1 - 0.046 13.4 4.0 0.084 12.6 2.7 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-IS66 PF13005.2 EPA05645.1 - 0.19 11.7 6.4 0.57 10.1 0.9 2.3 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 zf-FCS PF06467.9 EPA05645.1 - 1.3 8.7 8.6 7.1 6.3 0.5 3.1 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif OTT_1508_deam PF14441.1 EPA05645.1 - 2.8 7.7 5.3 55 3.5 3.7 2.0 1 1 0 1 1 1 0 OTT_1508-like deaminase Usp PF00582.21 EPA05646.1 - 5.6e-20 71.9 0.0 6.3e-20 71.7 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family ATP_bind_1 PF03029.12 EPA05647.1 - 4.1e-56 190.1 0.0 4.6e-56 190.0 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CbiA PF01656.18 EPA05647.1 - 0.00024 20.5 0.0 0.00033 20.1 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2075 PF09848.4 EPA05647.1 - 0.0013 17.8 0.1 0.0034 16.3 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ArgK PF03308.11 EPA05647.1 - 0.0019 16.9 0.0 0.0039 16.0 0.0 1.5 1 0 0 1 1 1 1 ArgK protein AAA_16 PF13191.1 EPA05647.1 - 0.0021 18.0 0.0 0.0033 17.4 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 EPA05647.1 - 0.0025 18.6 0.0 0.0045 17.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EPA05647.1 - 0.0035 17.6 0.0 0.0064 16.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 EPA05647.1 - 0.0039 17.1 0.2 0.013 15.4 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.17 EPA05647.1 - 0.023 14.1 0.1 1.2 8.4 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_22 PF13401.1 EPA05647.1 - 0.062 13.4 0.0 0.17 12.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 EPA05647.1 - 0.074 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EPA05647.1 - 0.082 12.3 0.0 0.13 11.6 0.0 1.5 1 1 0 1 1 1 0 AAA-like domain NTPase_1 PF03266.10 EPA05647.1 - 0.091 12.4 0.1 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 NTPase KaiC PF06745.8 EPA05647.1 - 0.1 11.7 0.1 0.26 10.3 0.1 1.7 1 1 0 1 1 1 0 KaiC PduV-EutP PF10662.4 EPA05647.1 - 0.24 10.8 1.3 11 5.4 0.0 3.3 3 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.14 EPA05647.1 - 0.45 9.9 2.2 9.6 5.6 1.5 2.7 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Usp PF00582.21 EPA05648.1 - 2.7e-27 95.6 0.0 3.3e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family DUF1761 PF08570.5 EPA05649.1 - 0.041 13.8 1.5 0.061 13.3 1.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1761) DUF3262 PF11660.3 EPA05649.1 - 0.071 13.2 0.6 0.15 12.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3262) PQ-loop PF04193.9 EPA05649.1 - 0.2 11.2 0.5 0.2 11.2 0.3 1.6 2 0 0 2 2 2 0 PQ loop repeat Class_IIIsignal PF04021.7 EPA05649.1 - 7.6 6.4 8.6 17 5.3 0.4 2.3 2 0 0 2 2 2 0 Class III signal peptide ACT_7 PF13840.1 EPA05650.1 - 3.2e-07 29.7 0.1 6.1e-07 28.8 0.1 1.5 1 0 0 1 1 1 1 ACT domain SecD-TM1 PF13721.1 EPA05650.1 - 0.032 14.4 0.3 0.083 13.1 0.0 1.7 2 0 0 2 2 2 0 SecD export protein N-terminal TM region Pox_A3L PF05288.6 EPA05650.1 - 0.12 12.0 0.2 0.6 9.8 0.0 2.2 2 1 0 2 2 2 0 Poxvirus A3L Protein CBS PF00571.23 EPA05651.1 - 7.3e-28 96.0 4.0 2.7e-14 52.6 0.1 2.2 2 0 0 2 2 2 2 CBS domain DisA_N PF02457.11 EPA05651.1 - 0.045 12.8 0.0 0.079 12.1 0.0 1.4 1 0 0 1 1 1 0 DisA bacterial checkpoint controller nucleotide-binding Serpin PF00079.15 EPA05651.1 - 0.51 9.4 1.9 0.45 9.5 0.3 1.6 2 0 0 2 2 2 0 Serpin (serine protease inhibitor) CBS PF00571.23 EPA05652.1 - 1.9e-52 174.7 10.3 6.7e-16 57.8 0.3 4.1 4 0 0 4 4 4 4 CBS domain PhnJ PF06007.6 EPA05652.1 - 0.09 11.5 0.5 0.54 8.9 0.0 2.0 2 0 0 2 2 2 0 Phosphonate metabolism protein PhnJ TFIIB PF00382.14 EPA05653.1 - 1.5e-33 114.4 2.9 5.3e-17 61.3 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EPA05653.1 - 9.9e-07 27.9 0.2 2.3e-06 26.8 0.2 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.18 EPA05653.1 - 1.1e-05 24.9 0.2 0.056 13.0 0.0 2.2 1 1 1 2 2 2 2 Cyclin, N-terminal domain HTH_11 PF08279.7 EPA05653.1 - 2.1e-05 24.0 1.4 0.0069 16.0 0.1 2.6 2 0 0 2 2 2 2 HTH domain P-II PF00543.17 EPA05654.1 - 8.7e-13 48.6 0.6 1.1e-12 48.2 0.4 1.1 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DUF1059 PF06348.6 EPA05655.1 - 3.6e-08 33.1 0.1 6.6e-08 32.2 0.0 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF1059) adh_short_C2 PF13561.1 EPA05656.1 - 9.6e-41 140.1 0.0 1.2e-40 139.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EPA05656.1 - 4.4e-30 104.7 0.0 5.4e-30 104.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EPA05656.1 - 8e-08 32.1 0.0 1.3e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EPA05656.1 - 0.0023 17.3 0.2 0.0038 16.6 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ATP-synt_ab PF00006.20 EPA05656.1 - 0.01 15.3 0.0 0.024 14.1 0.0 1.5 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain 3HCDH_N PF02737.13 EPA05656.1 - 0.015 14.9 0.2 0.023 14.3 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.14 EPA05656.1 - 0.042 12.9 0.1 0.074 12.1 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_Gly3P_dh_N PF01210.18 EPA05656.1 - 0.071 12.8 0.2 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus adh_short PF00106.20 EPA05657.1 - 1.8e-37 128.8 0.0 2e-37 128.6 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EPA05657.1 - 6.8e-16 58.4 0.0 9.1e-16 58.0 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EPA05657.1 - 1.4e-11 44.6 0.1 1.7e-11 44.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EPA05657.1 - 0.0001 22.3 0.0 0.00064 19.7 0.0 2.0 1 1 0 1 1 1 1 NADH(P)-binding DUF1776 PF08643.5 EPA05657.1 - 0.00043 19.5 0.0 0.002 17.3 0.0 1.8 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.3 EPA05657.1 - 0.0013 18.5 0.0 0.0027 17.4 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Polysacc_synt_2 PF02719.10 EPA05657.1 - 0.0013 17.6 0.1 0.0015 17.4 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.16 EPA05657.1 - 0.03 13.7 0.0 0.039 13.3 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DFP PF04127.10 EPA05657.1 - 0.035 13.7 0.0 0.078 12.5 0.0 1.5 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein DUF1664 PF07889.7 EPA05658.1 - 0.00011 21.9 5.1 0.00016 21.5 3.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Spc7 PF08317.6 EPA05658.1 - 0.00033 19.4 8.9 0.00042 19.0 6.1 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Tropomyosin_1 PF12718.2 EPA05658.1 - 0.002 18.0 14.7 0.014 15.2 7.9 2.3 1 1 2 3 3 3 1 Tropomyosin like IncA PF04156.9 EPA05658.1 - 0.0026 17.3 6.4 0.0029 17.2 4.5 1.2 1 0 0 1 1 1 1 IncA protein DUF812 PF05667.6 EPA05658.1 - 0.0034 15.9 5.5 0.0034 15.9 3.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Laminin_II PF06009.7 EPA05658.1 - 0.0045 16.7 6.9 0.0065 16.2 4.8 1.3 1 0 0 1 1 1 1 Laminin Domain II AAA_13 PF13166.1 EPA05658.1 - 0.0049 15.4 6.3 0.005 15.3 4.3 1.1 1 0 0 1 1 1 1 AAA domain AAA_27 PF13514.1 EPA05658.1 - 0.0093 13.7 2.9 0.011 13.4 2.0 1.1 1 0 0 1 1 1 1 AAA domain DUF4200 PF13863.1 EPA05658.1 - 0.012 15.5 10.9 0.023 14.6 5.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF3450 PF11932.3 EPA05658.1 - 0.014 14.7 2.3 0.018 14.2 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Sipho_Gp157 PF05565.6 EPA05658.1 - 0.014 14.9 10.8 0.19 11.3 2.7 2.2 1 1 1 2 2 2 0 Siphovirus Gp157 Baculo_PEP_C PF04513.7 EPA05658.1 - 0.024 14.4 0.2 0.035 13.9 0.1 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF972 PF06156.8 EPA05658.1 - 0.027 14.8 4.0 0.027 14.8 2.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Lebercilin PF15619.1 EPA05658.1 - 0.032 13.6 8.7 0.044 13.2 6.0 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Syntaxin PF00804.20 EPA05658.1 - 0.034 14.2 10.8 0.066 13.3 6.2 2.1 1 1 1 2 2 2 0 Syntaxin APG6 PF04111.7 EPA05658.1 - 0.054 12.5 5.2 0.063 12.3 3.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Mnd1 PF03962.10 EPA05658.1 - 0.059 13.0 7.8 0.046 13.3 4.6 1.4 1 1 0 1 1 1 0 Mnd1 family Matrilin_ccoil PF10393.4 EPA05658.1 - 0.064 12.6 0.5 1 8.7 0.2 2.5 2 1 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Reo_sigmaC PF04582.7 EPA05658.1 - 0.066 12.3 0.2 0.077 12.1 0.1 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Prefoldin PF02996.12 EPA05658.1 - 0.073 12.7 8.2 0.12 12.0 1.3 2.5 1 1 2 3 3 3 0 Prefoldin subunit NPV_P10 PF05531.7 EPA05658.1 - 0.11 12.7 6.8 0.63 10.3 1.1 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF316 PF03761.10 EPA05658.1 - 0.11 11.7 0.5 6.1 6.0 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF316) CENP-Q PF13094.1 EPA05658.1 - 0.14 12.1 6.9 0.21 11.5 4.8 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Atg14 PF10186.4 EPA05658.1 - 0.15 10.9 5.3 0.16 10.8 3.7 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4363 PF14276.1 EPA05658.1 - 0.18 11.5 4.0 0.28 10.8 2.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4363) FemAB PF02388.11 EPA05658.1 - 0.18 10.4 2.1 0.23 10.1 1.5 1.1 1 0 0 1 1 1 0 FemAB family Flagellin_C PF00700.16 EPA05658.1 - 0.22 11.6 1.9 1.9 8.7 0.0 2.2 2 0 0 2 2 2 0 Bacterial flagellin C-terminal helical region YlbD_coat PF14071.1 EPA05658.1 - 0.26 11.3 4.9 8.3 6.4 0.4 2.7 1 1 2 3 3 3 0 Putative coat protein HR1 PF02185.11 EPA05658.1 - 0.28 10.9 10.7 0.51 10.1 7.3 1.7 1 1 0 1 1 1 0 Hr1 repeat V_ATPase_I PF01496.14 EPA05658.1 - 0.29 8.9 5.7 0.31 8.8 3.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BLOC1_2 PF10046.4 EPA05658.1 - 0.34 11.0 8.4 3.5 7.8 5.9 2.4 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_DNA_bd PF12329.3 EPA05658.1 - 0.41 10.4 14.8 0.11 12.3 7.0 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF724 PF05266.9 EPA05658.1 - 0.47 10.0 6.1 0.65 9.5 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Snapin_Pallidin PF14712.1 EPA05658.1 - 0.56 10.5 5.4 2.8 8.2 3.0 2.0 1 1 0 1 1 1 0 Snapin/Pallidin Spectrin PF00435.16 EPA05658.1 - 0.56 10.5 6.9 2.1 8.6 3.6 2.3 1 1 1 2 2 2 0 Spectrin repeat DUF948 PF06103.6 EPA05658.1 - 0.57 10.0 3.9 1.7 8.5 0.7 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) HisKA PF00512.20 EPA05658.1 - 0.68 9.9 3.0 2.5 8.1 2.1 2.1 1 1 0 1 1 1 0 His Kinase A (phospho-acceptor) domain Erp_C PF06780.6 EPA05658.1 - 0.85 9.4 12.3 0.56 10.0 4.8 2.2 1 1 1 2 2 2 0 Erp protein C-terminus DUF4140 PF13600.1 EPA05658.1 - 1.2 9.6 5.0 15 6.0 0.6 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Fib_alpha PF08702.5 EPA05658.1 - 1.4 8.9 7.3 2 8.5 4.2 1.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family LLC1 PF14945.1 EPA05658.1 - 1.5 9.1 4.0 31 4.9 0.3 2.8 1 1 2 3 3 3 0 Normal lung function maintenance, Low in Lung Cancer 1 protein DUF848 PF05852.6 EPA05658.1 - 1.6 8.5 7.4 3.3 7.5 4.5 1.9 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) CorA PF01544.13 EPA05658.1 - 2 7.4 5.5 2.4 7.0 3.8 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Prefoldin_2 PF01920.15 EPA05658.1 - 3.7 7.3 13.2 3.7 7.3 0.6 2.8 1 1 1 2 2 2 0 Prefoldin subunit Uso1_p115_C PF04871.8 EPA05658.1 - 4.5 7.2 14.9 3.2 7.6 0.6 2.5 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Osmo_CC PF08946.5 EPA05658.1 - 4.9 7.2 14.4 2.2 8.3 4.1 3.5 1 1 3 4 4 4 0 Osmosensory transporter coiled coil Rabaptin PF03528.10 EPA05658.1 - 5.4 6.9 10.4 17 5.3 5.3 2.4 1 1 1 2 2 2 0 Rabaptin PAC2 PF09754.4 EPA05659.1 - 3.9e-30 105.3 0.0 4.7e-30 105.0 0.0 1.0 1 0 0 1 1 1 1 PAC2 family CRPA PF05745.6 EPA05660.1 - 0.043 13.5 2.7 0.049 13.4 1.9 1.1 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Lactate_perm PF02652.9 EPA05660.1 - 0.053 12.0 3.0 0.058 11.8 2.1 1.0 1 0 0 1 1 1 0 L-lactate permease DUF3671 PF12420.3 EPA05660.1 - 0.058 13.3 1.9 0.073 13.0 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function 7TMR-DISM_7TM PF07695.6 EPA05660.1 - 0.078 12.6 1.2 0.086 12.5 0.8 1.0 1 0 0 1 1 1 0 7TM diverse intracellular signalling DUF2842 PF11003.3 EPA05660.1 - 0.4 10.5 5.7 5 7.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2842) UPF0104 PF03706.8 EPA05661.1 - 1.5e-22 80.2 20.1 2.1e-22 79.7 13.9 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0104) SIS PF01380.17 EPA05661.1 - 0.00064 19.3 0.0 0.0012 18.3 0.0 1.5 1 0 0 1 1 1 1 SIS domain Spo7 PF03907.8 EPA05661.1 - 0.19 11.3 5.1 0.87 9.1 0.5 2.3 1 1 1 2 2 2 0 Spo7-like protein Inositol_P PF00459.20 EPA05662.1 - 3.1e-49 167.7 0.1 3.4e-49 167.5 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.15 EPA05662.1 - 0.0066 15.3 0.1 0.012 14.4 0.0 1.4 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase MTBP_N PF14918.1 EPA05662.1 - 0.028 13.8 0.0 0.095 12.0 0.0 1.8 2 0 0 2 2 2 0 MDM2-binding GTP_cyclohydroI PF01227.17 EPA05663.1 - 3.6e-64 215.3 0.1 4.2e-64 215.1 0.1 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.1 EPA05663.1 - 0.0026 17.6 0.0 0.0048 16.8 0.0 1.5 1 0 0 1 1 1 1 QueF-like protein PDEase_I PF00233.14 EPA05663.1 - 0.055 13.2 0.0 0.097 12.4 0.0 1.6 1 1 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase OST-HTH PF12872.2 EPA05663.1 - 0.12 12.2 0.0 9 6.2 0.0 2.3 2 0 0 2 2 2 0 OST-HTH/LOTUS domain Pyr_redox_2 PF07992.9 EPA05664.1 - 1.5e-21 77.1 0.0 1.4e-20 74.0 0.0 3.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EPA05664.1 - 6.8e-18 64.8 1.2 4e-12 46.3 0.3 3.3 3 1 1 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EPA05664.1 - 3.6e-05 22.8 0.6 4.3 6.1 0.0 4.0 4 0 0 4 4 4 3 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EPA05664.1 - 5.9e-05 23.2 0.0 0.0062 16.6 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EPA05664.1 - 0.0038 16.1 0.1 1.5 7.6 0.0 2.5 2 0 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_9 PF13454.1 EPA05664.1 - 0.0041 16.9 0.1 15 5.3 0.0 3.4 2 1 1 3 3 3 0 FAD-NAD(P)-binding DUF2356 PF10189.4 EPA05664.1 - 0.036 13.1 0.5 0.25 10.3 0.0 2.1 2 0 0 2 2 2 0 Conserved protein (DUF2356) Trp_halogenase PF04820.9 EPA05664.1 - 0.052 12.1 0.0 1.2 7.7 0.0 2.4 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_8 PF13450.1 EPA05664.1 - 0.057 13.4 0.1 12 6.0 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EPA05664.1 - 0.062 12.2 0.0 0.76 8.6 0.0 2.5 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.7 EPA05664.1 - 0.13 11.1 0.1 12 4.7 0.0 2.7 2 1 0 3 3 3 0 Lycopene cyclase protein FAD_binding_2 PF00890.19 EPA05664.1 - 0.41 9.4 1.5 47 2.6 0.2 3.4 4 0 0 4 4 4 0 FAD binding domain Usp PF00582.21 EPA05665.1 - 1.3e-30 106.3 0.0 1.8e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 Universal stress protein family DegS PF05384.6 EPA05665.1 - 0.1 11.8 0.1 0.13 11.4 0.1 1.1 1 0 0 1 1 1 0 Sensor protein DegS P-II PF00543.17 EPA05667.1 - 1.7e-08 34.8 1.1 2.8e-08 34.1 0.7 1.4 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II FGGY_N PF00370.16 EPA05667.1 - 0.065 12.5 0.0 0.15 11.3 0.0 1.5 1 1 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain HTH_45 PF14947.1 EPA05668.1 - 1.8e-07 30.8 0.0 2.2e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix MarR_2 PF12802.2 EPA05668.1 - 8.9e-06 25.2 0.0 1.2e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.1 EPA05668.1 - 0.00033 20.9 0.0 0.00041 20.6 0.0 1.1 1 0 0 1 1 1 1 Winged helix DNA-binding domain DUF4364 PF14277.1 EPA05668.1 - 0.021 14.4 0.0 0.025 14.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) DUF2250 PF10007.4 EPA05668.1 - 0.042 13.7 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) TrmB PF01978.14 EPA05668.1 - 0.044 13.4 0.1 0.072 12.8 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.2 EPA05668.1 - 0.075 12.8 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Rrf2 PF02082.15 EPA05668.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator Mrr_N PF14338.1 EPA05668.1 - 0.12 12.4 0.0 0.32 11.1 0.0 1.7 1 1 1 2 2 2 0 Mrr N-terminal domain HTH_24 PF13412.1 EPA05668.1 - 0.14 11.5 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding AAA PF00004.24 EPA05669.1 - 3.6e-100 331.3 0.0 6.5e-51 171.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 EPA05669.1 - 3.5e-22 78.1 0.0 9.9e-22 76.6 0.0 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 EPA05669.1 - 2.6e-16 60.0 0.1 3.4e-07 30.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 EPA05669.1 - 3.2e-14 52.5 0.0 1.3e-07 30.9 0.0 2.7 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EPA05669.1 - 4.2e-13 50.1 0.0 4.4e-05 24.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EPA05669.1 - 4.8e-13 49.4 0.0 1.8e-06 28.1 0.0 3.4 3 1 1 4 4 3 2 AAA ATPase domain AAA_5 PF07728.9 EPA05669.1 - 1e-12 47.9 1.4 0.00015 21.5 0.0 4.2 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EPA05669.1 - 2.3e-12 47.1 1.5 0.0021 18.2 0.2 4.5 2 2 1 3 3 3 2 AAA domain AAA_14 PF13173.1 EPA05669.1 - 3.2e-11 43.2 0.0 5.5e-05 23.0 0.0 3.0 3 0 0 3 3 2 2 AAA domain Zeta_toxin PF06414.7 EPA05669.1 - 6e-11 41.8 0.0 0.00014 21.0 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin TIP49 PF06068.8 EPA05669.1 - 2.5e-10 39.6 0.1 0.00053 18.8 0.0 2.7 2 0 0 2 2 2 2 TIP49 C-terminus AAA_33 PF13671.1 EPA05669.1 - 7.4e-10 38.8 0.0 0.00019 21.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.12 EPA05669.1 - 8.8e-10 38.0 0.7 2.6e-09 36.5 0.5 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 IstB_IS21 PF01695.12 EPA05669.1 - 2.9e-09 36.5 0.1 0.0019 17.6 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.16 EPA05669.1 - 1.3e-08 34.3 0.3 0.0016 17.6 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 EPA05669.1 - 2e-08 33.8 2.0 0.0065 16.1 0.0 2.8 2 0 0 2 2 2 2 Part of AAA domain AAA_18 PF13238.1 EPA05669.1 - 2.3e-08 34.4 0.8 0.0021 18.3 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.1 EPA05669.1 - 3.1e-07 30.0 5.8 0.12 11.7 0.2 4.2 2 2 0 3 3 3 2 AAA domain Sigma54_activat PF00158.21 EPA05669.1 - 9.1e-07 28.4 0.3 0.17 11.3 0.0 4.1 2 2 0 2 2 2 2 Sigma-54 interaction domain AAA_28 PF13521.1 EPA05669.1 - 1e-06 28.7 0.1 0.058 13.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 EPA05669.1 - 1.2e-06 28.6 0.0 0.056 13.6 0.0 2.6 2 0 0 2 2 2 2 RNA helicase ABC_tran PF00005.22 EPA05669.1 - 5e-06 26.8 0.1 0.17 12.1 0.0 3.0 2 0 0 2 2 2 2 ABC transporter AAA_3 PF07726.6 EPA05669.1 - 8.3e-06 25.4 0.0 0.025 14.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 EPA05669.1 - 1.3e-05 25.2 0.0 0.42 10.6 0.0 3.3 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_24 PF13479.1 EPA05669.1 - 2e-05 24.3 0.3 0.019 14.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 EPA05669.1 - 2.1e-05 24.2 0.8 0.46 10.1 0.1 3.9 4 0 0 4 4 4 2 NACHT domain DUF815 PF05673.8 EPA05669.1 - 2.5e-05 23.3 0.0 0.17 10.7 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF815) PhoH PF02562.11 EPA05669.1 - 3.4e-05 23.1 0.4 0.26 10.4 0.1 2.7 2 0 0 2 2 2 2 PhoH-like protein Parvo_NS1 PF01057.12 EPA05669.1 - 5.6e-05 22.1 0.2 0.13 11.1 0.0 2.4 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_11 PF13086.1 EPA05669.1 - 6.1e-05 22.7 0.2 0.11 12.0 0.0 2.6 2 2 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 EPA05669.1 - 8.9e-05 22.2 0.1 0.012 15.3 0.0 3.4 2 2 1 3 3 3 1 Archaeal ATPase ResIII PF04851.10 EPA05669.1 - 0.00014 21.7 0.2 0.079 12.7 0.0 3.3 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 EPA05669.1 - 0.00017 21.2 0.1 0.16 11.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.4 EPA05669.1 - 0.00042 19.4 0.1 0.53 9.1 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.10 EPA05669.1 - 0.00053 19.7 1.5 2.7 7.6 0.0 4.1 2 1 1 3 3 3 0 NTPase Guanylate_kin PF00625.16 EPA05669.1 - 0.0011 18.4 0.3 3.9 6.8 0.0 4.3 3 1 1 4 4 4 0 Guanylate kinase NB-ARC PF00931.17 EPA05669.1 - 0.0016 17.3 0.9 0.76 8.5 0.0 2.8 3 0 0 3 3 3 1 NB-ARC domain UPF0079 PF02367.12 EPA05669.1 - 0.0016 18.0 0.0 1.2 8.8 0.0 2.6 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 T2SE PF00437.15 EPA05669.1 - 0.0025 16.7 0.0 1.1 8.0 0.0 2.7 2 1 0 2 2 2 1 Type II/IV secretion system protein SKI PF01202.17 EPA05669.1 - 0.0027 17.6 0.2 1.5 8.6 0.0 2.6 2 0 0 2 2 2 1 Shikimate kinase CPT PF07931.7 EPA05669.1 - 0.0036 16.9 0.1 0.13 11.9 0.0 2.6 2 1 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein KaiC PF06745.8 EPA05669.1 - 0.0039 16.3 7.2 0.46 9.5 0.0 4.1 3 1 1 4 4 4 1 KaiC AFG1_ATPase PF03969.11 EPA05669.1 - 0.0049 15.7 0.0 1.7 7.3 0.0 2.4 2 0 0 2 2 2 1 AFG1-like ATPase UFD1 PF03152.9 EPA05669.1 - 0.0063 15.6 0.1 0.014 14.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Bac_DnaA PF00308.13 EPA05669.1 - 0.0084 15.7 0.0 0.3 10.6 0.0 2.6 2 1 0 2 2 2 1 Bacterial dnaA protein KTI12 PF08433.5 EPA05669.1 - 0.02 14.1 0.4 4.2 6.4 0.0 3.1 3 0 0 3 3 2 0 Chromatin associated protein KTI12 Viral_helicase1 PF01443.13 EPA05669.1 - 0.02 14.3 0.0 0.21 11.0 0.0 2.5 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.1 EPA05669.1 - 0.022 14.2 0.0 6.1 6.4 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATP-synt_ab PF00006.20 EPA05669.1 - 0.022 14.2 0.0 1.6 8.1 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain IPT PF01745.11 EPA05669.1 - 0.028 13.6 0.5 1.7 7.7 0.0 2.5 2 0 0 2 2 2 0 Isopentenyl transferase PIF1 PF05970.9 EPA05669.1 - 0.035 13.0 0.0 3.9 6.3 0.0 2.9 2 0 0 2 2 2 0 PIF1-like helicase Torsin PF06309.6 EPA05669.1 - 0.055 13.3 0.1 2.1 8.2 0.0 2.6 2 0 0 2 2 2 0 Torsin Vps4_C PF09336.5 EPA05669.1 - 0.13 12.2 2.8 9.9 6.1 0.0 3.8 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain DUF2443 PF10398.4 EPA05669.1 - 0.13 12.0 3.0 0.28 11.0 0.0 3.1 3 0 0 3 3 2 0 Protein of unknown function (DUF2443) PPV_E1_C PF00519.12 EPA05669.1 - 0.17 10.4 0.0 3.1 6.3 0.0 2.1 2 0 0 2 2 2 0 Papillomavirus helicase AAA_23 PF13476.1 EPA05669.1 - 0.5 10.6 10.1 0.96 9.7 0.6 3.9 1 1 1 2 2 2 0 AAA domain HicB PF05534.7 EPA05670.1 - 0.088 12.3 0.4 0.31 10.6 0.0 2.0 2 0 0 2 2 2 0 HicB family DUF3596 PF12167.3 EPA05671.1 - 0.0089 15.5 0.2 0.011 15.2 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3596) Glyco_hyd_65N_2 PF14498.1 EPA05671.1 - 0.022 14.4 0.1 0.023 14.3 0.0 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Imm42 PF15601.1 EPA05671.1 - 0.03 13.7 0.2 0.032 13.6 0.1 1.2 1 0 0 1 1 1 0 Immunity protein 42 DUF1043 PF06295.7 EPA05671.1 - 0.03 13.9 0.7 0.032 13.8 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Proteasom_PSMB PF10508.4 EPA05671.1 - 0.041 12.1 0.3 0.04 12.1 0.2 1.0 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit DUF4398 PF14346.1 EPA05671.1 - 0.052 13.5 0.1 0.056 13.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) LXG PF04740.7 EPA05671.1 - 0.064 13.0 1.9 0.077 12.7 1.2 1.3 1 1 0 1 1 1 0 LXG domain of WXG superfamily RHH_2 PF03693.9 EPA05671.1 - 0.066 13.3 0.0 0.07 13.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0156) GvpK PF05121.7 EPA05671.1 - 0.093 12.5 0.4 0.12 12.1 0.3 1.4 1 1 0 1 1 1 0 Gas vesicle protein K DUF2031 PF09592.5 EPA05671.1 - 0.098 11.7 0.7 0.095 11.8 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) Phage_lysis PF03245.8 EPA05671.1 - 0.1 12.5 0.6 0.13 12.2 0.3 1.3 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein HSCB_C PF07743.8 EPA05671.1 - 0.1 13.0 0.5 0.1 13.0 0.4 1.2 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain Snf7 PF03357.16 EPA05672.1 - 3.7e-05 23.1 5.5 6.2e-05 22.4 3.8 1.4 1 1 0 1 1 1 1 Snf7 Inp1 PF12634.2 EPA05672.1 - 0.013 15.1 0.1 0.023 14.3 0.1 1.5 1 0 0 1 1 1 0 Inheritance of peroxisomes protein 1 RVT_N PF13655.1 EPA05672.1 - 0.015 15.3 1.2 0.32 11.0 0.1 2.7 1 1 1 2 2 2 0 N-terminal domain of reverse transcriptase RHSP PF07999.6 EPA05672.1 - 0.031 12.8 0.1 0.036 12.6 0.0 1.1 1 0 0 1 1 1 0 Retrotransposon hot spot protein Nup54 PF13874.1 EPA05672.1 - 0.046 13.3 2.9 0.11 12.1 2.0 1.6 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 TMF_DNA_bd PF12329.3 EPA05672.1 - 0.05 13.4 1.0 0.05 13.4 0.7 2.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding BRE1 PF08647.6 EPA05672.1 - 0.054 13.4 2.3 0.15 12.0 0.3 2.5 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Baculo_PEP_C PF04513.7 EPA05672.1 - 0.055 13.2 4.6 0.72 9.6 3.2 2.2 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DivIVA PF05103.8 EPA05672.1 - 0.099 12.6 2.1 0.81 9.7 0.6 2.3 2 0 0 2 2 2 0 DivIVA protein Ribosomal_L22 PF00237.14 EPA05673.1 - 0.064 13.1 3.2 0.078 12.9 0.2 2.3 2 1 0 2 2 2 0 Ribosomal protein L22p/L17e GlcNAc_2-epim PF07221.6 EPA05673.1 - 0.15 11.0 3.4 0.22 10.5 0.5 2.0 2 0 0 2 2 2 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) DFF40 PF09230.5 EPA05673.1 - 0.65 9.3 5.5 3.1 7.0 0.7 2.2 2 0 0 2 2 2 0 DNA fragmentation factor 40 kDa ERp29 PF07749.7 EPA05673.1 - 1.6 9.3 9.8 2.6 8.7 1.0 2.9 1 1 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain Wbp11 PF09429.5 EPA05673.1 - 2 8.4 16.7 1.8 8.6 0.2 4.1 2 2 1 3 3 3 0 WW domain binding protein 11 Prp18 PF02840.10 EPA05673.1 - 6 6.6 13.5 2.8 7.7 1.1 2.5 1 1 0 2 2 2 0 Prp18 domain DUF1912 PF08930.5 EPA05673.1 - 8.8 6.4 7.4 2 8.5 1.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF1912) EcsC PF12787.2 EPA05673.1 - 9.2 5.5 13.8 12 5.2 3.3 2.4 1 1 1 2 2 2 0 EcsC protein family QueC PF06508.8 EPA05675.1 - 8.4e-48 162.4 0.0 9.7e-48 162.2 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Arginosuc_synth PF00764.14 EPA05675.1 - 7.7e-05 21.9 0.0 8.9e-05 21.6 0.0 1.1 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.16 EPA05675.1 - 0.00018 21.0 0.0 0.00028 20.4 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.12 EPA05675.1 - 0.0052 15.7 0.0 0.007 15.2 0.0 1.2 1 0 0 1 1 1 1 NAD synthase ATP_bind_3 PF01171.15 EPA05675.1 - 0.029 13.8 0.0 0.048 13.1 0.0 1.4 1 0 0 1 1 1 0 PP-loop family DUF3836 PF12930.2 EPA05676.1 - 0.025 14.0 0.2 0.032 13.7 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF3836) DUF2977 PF11192.3 EPA05676.1 - 0.14 12.0 2.5 0.12 12.2 0.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2977) lci PF12197.3 EPA05676.1 - 7.1 6.2 7.3 1.4 8.5 0.1 2.9 3 1 0 3 3 3 0 Bacillus cereus group antimicrobial protein TFIIB PF00382.14 EPA05677.1 - 5.6e-34 115.7 6.6 1.4e-17 63.2 0.3 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EPA05677.1 - 2.6e-11 42.6 0.4 4.6e-11 41.8 0.2 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.18 EPA05677.1 - 0.0011 18.5 0.1 0.057 12.9 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Sigma70_r4 PF04545.11 EPA05677.1 - 0.0049 16.1 0.0 0.014 14.7 0.0 1.8 1 0 0 1 1 1 1 Sigma-70, region 4 AAA_27 PF13514.1 EPA05677.1 - 0.0053 14.5 0.6 0.0066 14.2 0.4 1.0 1 0 0 1 1 1 1 AAA domain HTH_11 PF08279.7 EPA05677.1 - 0.0054 16.3 0.2 0.16 11.6 0.0 2.8 3 0 0 3 3 3 1 HTH domain zf-ribbon_3 PF13248.1 EPA05677.1 - 0.0069 15.5 1.0 0.014 14.5 0.7 1.5 1 0 0 1 1 1 1 zinc-ribbon domain HTH_AsnC-type PF13404.1 EPA05677.1 - 0.018 14.5 0.0 0.15 11.6 0.0 2.3 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain Sigma70_r4_2 PF08281.7 EPA05677.1 - 0.018 14.5 0.2 0.23 10.9 0.0 2.4 2 0 0 2 2 2 0 Sigma-70, region 4 RRN7 PF11781.3 EPA05677.1 - 0.033 13.6 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase I-specific transcription initiation factor Rrn7 Baculo_ME53 PF06061.6 EPA05677.1 - 0.039 12.9 0.1 0.057 12.3 0.1 1.2 1 0 0 1 1 1 0 Baculoviridae ME53 DZR PF12773.2 EPA05677.1 - 0.04 13.7 1.0 0.088 12.6 0.7 1.5 1 0 0 1 1 1 0 Double zinc ribbon RPA_interact_C PF14768.1 EPA05677.1 - 0.089 13.1 0.7 0.2 12.0 0.1 1.9 2 0 0 2 2 1 0 Replication protein A interacting C-terminal zf-FPG_IleRS PF06827.9 EPA05677.1 - 0.097 12.3 0.5 0.67 9.6 0.0 2.4 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS HTH_23 PF13384.1 EPA05677.1 - 0.15 11.7 2.4 0.19 11.4 0.0 2.4 3 0 0 3 3 3 0 Homeodomain-like domain zinc_ribbon_2 PF13240.1 EPA05677.1 - 0.19 11.2 0.3 0.19 11.2 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain GHMP_kinases_N PF00288.21 EPA05678.1 - 3.3e-16 59.0 1.5 7.3e-16 57.9 1.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EPA05678.1 - 1.4e-08 34.8 0.0 2.9e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal S_100 PF01023.14 EPA05680.1 - 0.018 14.3 2.7 2.8 7.3 0.1 2.5 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain Alginate_exp PF13372.1 EPA05680.1 - 0.023 13.3 0.0 0.027 13.1 0.0 1.0 1 0 0 1 1 1 0 Alginate export IL5 PF02025.10 EPA05680.1 - 0.027 14.5 0.1 0.031 14.3 0.1 1.1 1 0 0 1 1 1 0 Interleukin 5 HTH_24 PF13412.1 EPA05682.1 - 0.0019 17.5 0.0 0.0079 15.5 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding CRCB PF02537.10 EPA05683.1 - 3.1e-24 85.0 6.6 3.6e-24 84.9 4.6 1.0 1 0 0 1 1 1 1 CrcB-like protein DUF2104 PF09877.4 EPA05683.1 - 0.023 14.6 0.4 0.023 14.6 0.2 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2104) CBS PF00571.23 EPA05684.1 - 5.1e-29 99.7 0.7 5.6e-14 51.6 0.0 2.1 2 0 0 2 2 2 2 CBS domain Oligomerisation PF02410.10 EPA05684.1 - 0.031 14.3 0.2 0.072 13.1 0.1 1.6 1 0 0 1 1 1 0 Oligomerisation domain FA_desaturase_2 PF03405.9 EPA05684.1 - 0.036 12.8 0.2 0.053 12.2 0.1 1.4 1 1 0 1 1 1 0 Fatty acid desaturase HSP20 PF00011.16 EPA05685.1 - 4.4e-13 48.9 0.0 5.9e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family CS PF04969.11 EPA05685.1 - 0.00019 21.9 3.1 0.00074 20.0 2.2 1.9 1 1 0 1 1 1 1 CS domain DUF4097 PF13349.1 EPA05685.1 - 0.012 15.1 0.7 0.016 14.7 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4097) MFS_2 PF13347.1 EPA05686.1 - 0.0051 15.2 1.8 0.0055 15.1 1.3 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein Tetraspannin PF00335.15 EPA05686.1 - 0.25 10.5 3.6 0.3 10.3 2.5 1.0 1 0 0 1 1 1 0 Tetraspanin family DUF2892 PF11127.3 EPA05686.1 - 0.52 10.1 3.5 0.65 9.8 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2892) DUF2530 PF10745.4 EPA05686.1 - 1.7 8.6 4.3 2.9 7.9 3.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2530) DUF3185 PF11381.3 EPA05686.1 - 1.8 8.3 7.7 68 3.3 5.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3185) NfeD PF01957.13 EPA05686.1 - 2.1 8.5 5.8 3 7.9 4.0 1.3 1 1 0 1 1 1 0 NfeD-like C-terminal, partner-binding SKG6 PF08693.5 EPA05686.1 - 8.8 5.7 8.2 0.37 10.1 0.7 2.0 2 0 0 2 2 2 0 Transmembrane alpha-helix domain TFIIB PF00382.14 EPA05687.1 - 1.5e-34 117.6 1.7 8.2e-17 60.7 0.0 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EPA05687.1 - 1.3e-09 37.2 0.6 2.1e-09 36.5 0.4 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Sigma70_r4 PF04545.11 EPA05687.1 - 0.00024 20.3 0.0 0.025 13.8 0.0 2.5 2 0 0 2 2 2 1 Sigma-70, region 4 Cyclin_N PF00134.18 EPA05687.1 - 0.00049 19.6 0.0 0.023 14.2 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain A2L_zn_ribbon PF08792.5 EPA05687.1 - 0.0012 18.2 0.7 0.0021 17.4 0.5 1.4 1 0 0 1 1 1 1 A2L zinc ribbon domain Cyclin_C PF02984.14 EPA05687.1 - 0.011 15.6 0.0 2.6 7.9 0.0 2.4 2 1 0 2 2 2 0 Cyclin, C-terminal domain HTH_11 PF08279.7 EPA05687.1 - 0.02 14.5 1.4 0.69 9.6 0.0 2.8 3 0 0 3 3 3 0 HTH domain Sigma70_r4_2 PF08281.7 EPA05687.1 - 0.061 12.7 0.0 0.15 11.5 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 DZR PF12773.2 EPA05687.1 - 0.14 12.0 1.1 0.28 11.0 0.8 1.5 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.1 EPA05687.1 - 0.16 11.2 0.7 0.33 10.2 0.5 1.6 1 0 0 1 1 1 0 zinc-ribbon domain Evr1_Alr PF04777.8 EPA05689.1 - 0.0052 16.6 0.1 0.0055 16.5 0.1 1.1 1 0 0 1 1 1 1 Erv1 / Alr family dCMP_cyt_deam_1 PF00383.17 EPA05689.1 - 0.061 12.9 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region XOO_2897-deam PF14440.1 EPA05689.1 - 0.11 12.2 0.3 0.15 11.8 0.1 1.4 1 1 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase CBS PF00571.23 EPA05690.1 - 2.2e-27 94.5 1.5 1.9e-08 33.9 0.1 4.3 4 0 0 4 4 4 4 CBS domain Ribosomal_S30AE PF02482.14 EPA05690.1 - 0.0028 18.0 0.4 0.0089 16.4 0.3 1.9 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein NLE PF08154.7 EPA05690.1 - 0.031 14.2 0.5 2.4 8.2 0.0 2.9 3 0 0 3 3 3 0 NLE (NUC135) domain Lar_restr_allev PF14354.1 EPA05691.1 - 0.0039 17.4 0.1 0.0051 17.0 0.1 1.1 1 0 0 1 1 1 1 Restriction alleviation protein Lar DUF2225 PF09986.4 EPA05691.1 - 0.026 13.9 1.5 0.063 12.7 1.0 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) TF_Zn_Ribbon PF08271.7 EPA05691.1 - 0.045 13.0 0.7 6 6.2 0.0 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding zf-ISL3 PF14690.1 EPA05691.1 - 0.053 13.5 0.1 4.7 7.3 0.0 2.1 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Rubredoxin PF00301.15 EPA05691.1 - 0.074 12.9 0.3 7.6 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubredoxin DUF2082 PF09855.4 EPA05691.1 - 0.08 12.8 2.0 0.21 11.4 1.4 1.7 1 1 0 1 1 1 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Zn-ribbon_8 PF09723.5 EPA05691.1 - 0.11 12.4 0.8 4.3 7.3 0.1 2.2 2 0 0 2 2 2 0 Zinc ribbon domain Methyltransf_13 PF08421.6 EPA05691.1 - 0.12 11.9 0.4 0.34 10.4 0.0 1.8 2 0 0 2 2 2 0 Putative zinc binding domain TFIIS_C PF01096.13 EPA05691.1 - 0.14 11.7 2.1 6 6.5 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) HypA PF01155.14 EPA05691.1 - 0.2 11.3 1.2 1.8 8.2 0.1 2.0 1 1 0 2 2 2 0 Hydrogenase expression/synthesis hypA family RRN7 PF11781.3 EPA05691.1 - 0.22 11.0 1.3 5.6 6.5 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-Sec23_Sec24 PF04810.10 EPA05691.1 - 0.23 11.0 2.9 3 7.4 0.5 2.2 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Opy2 PF09463.5 EPA05691.1 - 0.71 10.0 3.5 1.2 9.3 0.2 2.1 2 0 0 2 2 2 0 Opy2 protein zinc_ribbon_4 PF13717.1 EPA05691.1 - 2.1 8.1 4.6 4.5 7.0 0.2 2.2 1 1 2 3 3 3 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 EPA05691.1 - 2.5 7.7 4.9 4.5 6.9 0.2 2.2 1 1 2 3 3 3 0 zinc-ribbon domain P3A PF08727.6 EPA05692.1 - 0.0087 15.3 0.3 0.032 13.5 0.0 2.1 3 0 0 3 3 3 1 Poliovirus 3A protein like ILVD_EDD PF00920.16 EPA05693.1 - 4.3e-166 553.3 3.2 4.9e-166 553.1 2.2 1.0 1 0 0 1 1 1 1 Dehydratase family T2SF PF00482.18 EPA05694.1 - 0.0081 16.0 0.7 0.0081 16.0 0.5 2.1 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein F DUF2214 PF09980.4 EPA05694.1 - 0.2 11.3 3.3 0.38 10.4 0.2 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2214) Oxidored_q4 PF00507.14 EPA05694.1 - 4.2 7.2 7.1 5.9 6.7 4.9 1.3 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Pyridox_oxidase PF01243.15 EPA05695.1 - 1.2e-12 47.6 0.0 1.4e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 EPA05695.1 - 1.5e-07 31.3 0.0 1.9e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF447 PF04289.7 EPA05695.1 - 0.043 13.3 0.0 0.045 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF447) Tox-ART-HYE1 PF15634.1 EPA05696.1 - 0.096 11.6 0.2 0.095 11.6 0.1 1.0 1 0 0 1 1 1 0 HYE1 signature containing ADP-ribosyltransferase Rotamase_3 PF13616.1 EPA05697.1 - 6.6e-27 94.1 0.1 7.7e-27 93.8 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.16 EPA05697.1 - 1.2e-25 90.0 0.1 1.4e-25 89.8 0.1 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 EPA05697.1 - 1.4e-09 38.6 0.0 1.7e-09 38.3 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain NTPase_I-T PF01931.13 EPA05697.1 - 0.082 12.6 0.0 0.099 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF84 PapD_C PF02753.12 EPA05697.1 - 0.088 12.6 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Pili assembly chaperone PapD, C-terminal domain DUF2407_C PF13373.1 EPA05698.1 - 0.073 12.9 0.0 0.078 12.9 0.0 1.2 1 0 0 1 1 1 0 DUF2407 C-terminal domain TrmB PF01978.14 EPA05699.1 - 3.9e-14 52.1 0.1 8.2e-14 51.0 0.1 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.2 EPA05699.1 - 9.8e-06 25.1 0.0 1.8e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.2 EPA05699.1 - 0.00018 21.2 0.0 0.00043 20.0 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.17 EPA05699.1 - 0.0018 17.9 0.0 0.0045 16.6 0.0 1.7 1 0 0 1 1 1 1 MarR family Regulator_TrmB PF11495.3 EPA05699.1 - 0.013 14.4 0.1 0.019 13.9 0.0 1.2 1 0 0 1 1 1 0 Archaeal transcriptional regulator TrmB HTH_24 PF13412.1 EPA05699.1 - 0.051 12.9 0.1 0.1 12.0 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_11 PF08279.7 EPA05699.1 - 0.071 12.7 0.7 0.31 10.7 0.1 2.3 2 0 0 2 2 2 0 HTH domain HTH_27 PF13463.1 EPA05699.1 - 0.1 12.9 0.1 0.24 11.7 0.1 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_34 PF13601.1 EPA05699.1 - 0.11 12.5 0.2 0.71 9.9 0.0 2.4 3 0 0 3 3 3 0 Winged helix DNA-binding domain T2SF PF00482.18 EPA05700.1 - 2.3e-15 56.5 0.3 2.3e-15 56.5 0.2 2.1 3 0 0 3 3 3 1 Type II secretion system (T2SS), protein F MtrG PF04210.8 EPA05700.1 - 0.0047 16.5 0.4 0.045 13.4 0.2 2.5 2 0 0 2 2 2 1 Tetrahydromethanopterin S-methyltransferase, subunit G DUF3671 PF12420.3 EPA05700.1 - 0.043 13.7 7.8 0.081 12.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function Spore_III_AB PF09548.5 EPA05700.1 - 0.051 13.3 2.2 0.18 11.5 0.1 2.3 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) DUF2203 PF09969.4 EPA05701.1 - 9.5e-37 125.8 0.2 1.1e-36 125.7 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2203) CENP-K PF11802.3 EPA05701.1 - 0.029 13.6 0.2 0.034 13.3 0.1 1.1 1 0 0 1 1 1 0 Centromere-associated protein K DUF4450 PF14614.1 EPA05701.1 - 0.037 13.1 0.0 0.051 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4450) Bet_v_1 PF00407.14 EPA05701.1 - 0.072 12.7 0.1 0.18 11.4 0.0 1.6 1 1 0 1 1 1 0 Pathogenesis-related protein Bet v I family Helicase_C PF00271.26 EPA05702.1 - 1.3e-20 73.0 0.2 3.5e-20 71.6 0.2 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EPA05702.1 - 9.3e-20 70.7 0.1 1.3e-18 67.0 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 EPA05702.1 - 1.3e-17 64.2 0.0 3.4e-17 62.8 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 EPA05702.1 - 0.00052 18.8 0.0 0.00084 18.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C_2 PF13307.1 EPA05702.1 - 0.001 19.0 0.0 0.13 12.2 0.0 2.4 2 0 0 2 2 2 1 Helicase C-terminal domain AAA_19 PF13245.1 EPA05702.1 - 0.0016 18.1 0.0 0.0057 16.3 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain Flavi_DEAD PF07652.9 EPA05702.1 - 0.0028 17.4 0.0 0.0065 16.2 0.0 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain DUF2007 PF09413.5 EPA05702.1 - 0.12 12.2 0.1 0.78 9.6 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF2007) BNR PF02012.15 EPA05703.1 - 2.1 8.5 13.0 2.6 8.2 0.3 4.8 4 0 0 4 4 4 0 BNR/Asp-box repeat Laminin_G_3 PF13385.1 EPA05704.1 - 1.1e-13 51.6 0.0 1.9e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Cu_bind_like PF02298.12 EPA05704.1 - 0.088 12.6 0.0 13 5.6 0.0 2.8 3 0 0 3 3 3 0 Plastocyanin-like domain DUF2099 PF09872.4 EPA05704.1 - 0.11 11.4 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2099) CBS PF00571.23 EPA05705.1 - 5.5e-18 64.4 0.2 1.8e-08 34.0 0.0 2.1 2 0 0 2 2 2 2 CBS domain RNA_pol_Rpb1_1 PF04997.7 EPA05705.1 - 0.034 13.4 0.5 0.043 13.0 0.3 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 NPR1_like_C PF12313.3 EPA05705.1 - 0.037 13.4 0.1 0.055 12.8 0.1 1.3 1 1 0 1 1 1 0 NPR1/NIM1 like defence protein C terminal LINES_N PF14694.1 EPA05705.1 - 0.074 12.3 0.2 0.091 12.0 0.1 1.1 1 0 0 1 1 1 0 Lines N-terminus DUF4409 PF14365.1 EPA05706.1 - 0.082 13.0 0.2 0.095 12.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4409) YgaB PF14182.1 EPA05707.1 - 0.03 14.5 0.3 0.03 14.5 0.2 1.0 1 0 0 1 1 1 0 YgaB-like protein DUF4423 PF14394.1 EPA05707.1 - 0.18 11.3 0.6 0.19 11.2 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) DNase-RNase PF02577.9 EPA05708.1 - 7.9e-08 31.5 0.0 8.6e-08 31.4 0.0 1.0 1 0 0 1 1 1 1 Bifunctional nuclease TDH PF03347.8 EPA05708.1 - 0.088 12.3 0.1 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Vibrio thermostable direct hemolysin CbtB PF09489.5 EPA05709.1 - 2e-06 27.5 10.5 9.9e-05 22.1 7.2 2.2 1 1 0 1 1 1 1 Probable cobalt transporter subunit (CbtB) HIT PF01230.18 EPA05710.1 - 2e-23 82.7 1.8 2.6e-23 82.3 1.2 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 EPA05710.1 - 3.7e-11 43.2 0.6 4.6e-11 42.9 0.4 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 EPA05710.1 - 0.057 13.0 1.0 0.09 12.4 0.7 1.3 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 SMC_hinge PF06470.8 EPA05710.1 - 0.064 13.2 0.0 0.098 12.6 0.0 1.3 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain MarB PF13999.1 EPA05710.1 - 0.22 11.1 0.6 0.61 9.6 0.1 1.9 2 1 0 2 2 2 0 MarB protein eRF1_3 PF03465.10 EPA05711.1 - 1.3e-18 67.2 0.1 2.3e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.10 EPA05711.1 - 5.1e-11 43.0 0.0 1.6e-10 41.4 0.0 1.8 2 0 0 2 2 2 1 eRF1 domain 2 DUF3795 PF12675.2 EPA05711.1 - 0.038 14.1 1.5 0.061 13.5 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3795) OrfB_Zn_ribbon PF07282.6 EPA05711.1 - 0.45 10.2 3.7 0.28 10.8 0.2 2.2 1 1 2 3 3 3 0 Putative transposase DNA-binding domain eRF1_1 PF03463.10 EPA05712.1 - 1.3e-18 66.8 0.0 1.7e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 eRF1 domain 1 Thioredoxin_4 PF13462.1 EPA05713.1 - 2.4e-34 118.6 0.1 2.8e-34 118.4 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.15 EPA05713.1 - 7.3e-16 58.3 0.0 7.7e-15 54.9 0.0 1.9 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.1 EPA05713.1 - 1.2e-08 35.1 0.2 3.4e-08 33.6 0.1 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_5 PF13743.1 EPA05713.1 - 6.8e-05 22.4 0.0 7.6e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin HTH_20 PF12840.2 EPA05714.1 - 1e-08 34.8 0.0 1.5e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.14 EPA05714.1 - 2e-06 27.4 0.8 3.6e-06 26.6 0.3 1.7 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB TFIIE_alpha PF02002.12 EPA05714.1 - 2.9e-05 23.4 0.6 3.6e-05 23.2 0.4 1.1 1 0 0 1 1 1 1 TFIIE alpha subunit HTH_5 PF01022.15 EPA05714.1 - 0.00059 19.4 0.4 0.0011 18.6 0.3 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family DUF742 PF05331.6 EPA05714.1 - 0.0013 18.3 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF742) HTH_11 PF08279.7 EPA05714.1 - 0.0025 17.4 0.8 0.0046 16.5 0.6 1.4 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.1 EPA05714.1 - 0.0041 16.4 1.1 0.011 15.1 0.3 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.5 EPA05714.1 - 0.0041 16.6 0.0 0.0065 16.0 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain ArsR PF09824.4 EPA05714.1 - 0.0092 15.3 0.2 0.012 14.9 0.1 1.1 1 0 0 1 1 1 1 ArsR transcriptional regulator DUF2250 PF10007.4 EPA05714.1 - 0.011 15.6 0.6 0.015 15.2 0.3 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) Mga PF05043.8 EPA05714.1 - 0.011 15.9 2.2 0.073 13.3 0.4 2.1 1 1 1 2 2 2 0 Mga helix-turn-helix domain MarR_2 PF12802.2 EPA05714.1 - 0.015 14.9 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 MarR family SdiA-regulated PF06977.6 EPA05714.1 - 0.017 14.1 0.0 0.019 13.9 0.0 1.0 1 0 0 1 1 1 0 SdiA-regulated PadR PF03551.9 EPA05714.1 - 0.028 14.1 0.1 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family DUF1492 PF07374.6 EPA05714.1 - 0.031 14.3 0.2 0.047 13.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) HTH_34 PF13601.1 EPA05714.1 - 0.045 13.7 0.2 0.071 13.1 0.1 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain DDE_Tnp_2 PF04693.7 EPA05714.1 - 0.047 12.6 0.1 0.057 12.4 0.0 1.1 1 0 0 1 1 1 0 Archaeal putative transposase ISC1217 Sulfolobus_pRN PF05584.6 EPA05714.1 - 0.048 13.6 0.4 0.11 12.4 0.2 1.6 1 1 1 2 2 2 0 Sulfolobus plasmid regulatory protein YycC PF14174.1 EPA05714.1 - 0.065 12.9 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 YycC-like protein FUR PF01475.14 EPA05714.1 - 0.11 12.4 0.1 0.14 12.0 0.1 1.3 1 1 0 1 1 1 0 Ferric uptake regulator family CbtA PF09490.5 EPA05715.1 - 1.6e-17 63.6 0.4 2e-17 63.2 0.3 1.1 1 0 0 1 1 1 1 Probable cobalt transporter subunit (CbtA) Mem_trans PF03547.13 EPA05715.1 - 0.025 12.8 6.0 0.085 11.1 4.2 1.9 1 1 0 1 1 1 0 Membrane transport protein DUF4443 PF14544.1 EPA05716.1 - 1.5e-05 24.8 0.0 2.9e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4443) HTH_45 PF14947.1 EPA05716.1 - 0.0026 17.5 0.2 0.0075 16.0 0.2 1.8 1 1 0 1 1 1 1 Winged helix-turn-helix Flg_new PF09479.5 EPA05719.1 - 0.0006 19.8 10.3 2.3 8.3 0.1 4.6 4 0 0 4 4 4 3 Listeria-Bacteroides repeat domain (List_Bact_rpt) Na_H_Exchanger PF00999.16 EPA05720.1 - 4.9e-37 127.3 46.9 6.8e-37 126.8 32.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family RNA_binding PF01877.12 EPA05722.1 - 2.7e-17 62.8 0.1 6e-17 61.7 0.1 1.5 1 1 0 1 1 1 1 RNA binding tRNA-synt_1g PF09334.6 EPA05722.1 - 0.0022 16.7 0.0 0.0025 16.5 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (M) SAF PF08666.7 EPA05724.1 - 0.00021 21.5 0.0 0.00022 21.5 0.0 1.0 1 0 0 1 1 1 1 SAF domain DUF3284 PF11687.3 EPA05724.1 - 0.0035 17.0 0.1 0.0035 17.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3284) Glycos_transf_1 PF00534.15 EPA05725.1 - 7.1e-35 119.9 0.2 1.1e-34 119.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EPA05725.1 - 4.1e-17 62.5 0.0 6.3e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EPA05725.1 - 7e-14 51.8 0.0 1.3e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 INCENP_N PF12178.3 EPA05725.1 - 0.14 11.7 0.5 0.29 10.6 0.3 1.5 1 0 0 1 1 1 0 Chromosome passenger complex (CPC) protein INCENP N terminal Glyco_transf_5 PF08323.6 EPA05726.1 - 0.00045 19.7 0.0 0.00046 19.7 0.0 1.0 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_4 PF13579.1 EPA05726.1 - 0.00057 20.0 0.0 0.00061 19.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.1 EPA05726.1 - 0.0016 18.1 0.0 0.0016 18.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_2 PF13477.1 EPA05726.1 - 0.0034 17.2 0.0 0.0037 17.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl transferase 4-like EFP PF01132.15 EPA05726.1 - 0.014 15.1 0.0 0.015 14.9 0.0 1.1 1 0 0 1 1 1 0 Elongation factor P (EF-P) OB domain TusA PF01206.12 EPA05726.1 - 0.13 11.8 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Sulfurtransferase TusA Epimerase_2 PF02350.14 EPA05727.1 - 1.5e-72 244.3 2.2 1.6e-72 244.1 1.5 1.0 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase MGDG_synth PF06925.6 EPA05727.1 - 0.00018 21.4 2.3 0.028 14.3 0.0 3.1 4 0 0 4 4 4 2 Monogalactosyldiacylglycerol (MGDG) synthase CHRD PF07452.7 EPA05727.1 - 0.036 14.6 0.1 0.12 12.9 0.1 1.9 1 1 0 1 1 1 0 CHRD domain Ribonuclease_T2 PF00445.13 EPA05727.1 - 1.5 8.3 3.8 7.9 6.0 0.6 2.2 2 0 0 2 2 2 0 Ribonuclease T2 family NeuB PF03102.9 EPA05728.1 - 1.6e-68 230.4 0.1 1.9e-68 230.1 0.1 1.0 1 0 0 1 1 1 1 NeuB family Polysacc_synt_2 PF02719.10 EPA05729.1 - 2e-18 66.3 0.0 2.5e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RNase_Zc3h12a_2 PF14626.1 EPA05729.1 - 0.1 12.4 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain NeuB PF03102.9 EPA05730.1 - 8.2e-07 28.4 0.0 9.1e-07 28.2 0.0 1.0 1 0 0 1 1 1 1 NeuB family Epimerase PF01370.16 EPA05732.1 - 2.4e-39 135.1 0.0 3.1e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EPA05732.1 - 1.5e-21 76.4 0.1 1.3e-19 70.1 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.10 EPA05732.1 - 4.3e-18 65.2 0.3 1e-15 57.4 0.0 2.7 1 1 1 2 2 2 2 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 EPA05732.1 - 4.4e-18 64.9 0.7 7.9e-16 57.5 0.4 2.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EPA05732.1 - 8.7e-17 60.9 0.0 1.1e-16 60.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 EPA05732.1 - 6.5e-10 39.3 0.0 1.1e-09 38.5 0.0 1.4 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 EPA05732.1 - 0.012 15.5 0.0 1.6 8.6 0.0 2.3 1 1 1 2 2 2 0 short chain dehydrogenase tRNA-synt_1 PF00133.17 EPA05733.1 - 9.1e-16 56.9 0.2 3.7e-15 54.9 0.1 1.7 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 EPA05733.1 - 1.8e-11 43.3 0.0 3.8e-11 42.2 0.0 1.5 1 1 1 2 2 2 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 EPA05733.1 - 7.4e-07 28.5 0.0 1.1e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain LMWPc PF01451.16 EPA05734.1 - 5.7e-28 97.9 0.1 6.6e-28 97.7 0.1 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Response_reg PF00072.19 EPA05735.1 - 4.6e-23 81.3 0.5 5.3e-23 81.1 0.4 1.0 1 0 0 1 1 1 1 Response regulator receiver domain ADH_N PF08240.7 EPA05736.1 - 0.00025 20.7 0.0 0.00035 20.3 0.0 1.2 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ATG19_autophagy PF12744.2 EPA05737.1 - 0.016 14.4 0.2 0.019 14.2 0.2 1.2 1 0 0 1 1 1 0 Autophagy protein Atg19, Atg8-binding IL12p40_C PF10420.4 EPA05737.1 - 0.11 12.6 0.4 0.15 12.1 0.3 1.2 1 0 0 1 1 1 0 Cytokine interleukin-12p40 C-terminus DM13 PF10517.4 EPA05738.1 - 6.8e-20 71.4 0.0 7.9e-20 71.2 0.0 1.0 1 0 0 1 1 1 1 Electron transfer DM13 Pribosyltran PF00156.22 EPA05742.1 - 4e-17 62.0 0.1 5.4e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 EPA05742.1 - 0.0049 16.1 0.0 0.0061 15.7 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase zf-met PF12874.2 EPA05743.1 - 0.062 13.5 0.4 0.12 12.6 0.2 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type A2M_N PF01835.14 EPA05744.1 - 6.9e-12 45.4 0.0 1.8e-07 31.3 0.0 2.2 1 1 1 2 2 2 2 MG2 domain FlgD_ig PF13860.1 EPA05744.1 - 2.5e-07 30.3 0.3 0.0011 18.6 0.1 2.7 2 1 0 2 2 2 2 FlgD Ig-like domain DUF1973 PF09315.6 EPA05744.1 - 5.1e-06 26.0 0.1 9.9e-06 25.0 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1973) Cna_B PF05738.8 EPA05744.1 - 0.00029 20.5 0.1 0.066 12.9 0.1 2.6 2 1 0 2 2 2 1 Cna protein B-type domain DUF4625 PF15418.1 EPA05744.1 - 0.01 15.9 0.0 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) DoxA PF07680.6 EPA05744.1 - 0.021 14.4 0.8 1.8 8.2 0.0 2.9 1 1 2 3 3 3 0 TQO small subunit DoxA Big_1 PF02369.11 EPA05744.1 - 0.037 13.9 0.2 2.2 8.2 0.1 2.5 2 2 0 2 2 2 0 Bacterial Ig-like domain (group 1) DUF1846 PF08903.6 EPA05744.1 - 0.052 12.0 0.3 0.068 11.6 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) Pox_M2 PF04887.7 EPA05744.1 - 0.14 11.4 1.2 1.3 8.2 0.2 2.1 2 0 0 2 2 2 0 Poxvirus M2 protein AAA_15 PF13175.1 EPA05746.1 - 5.4e-17 61.9 10.3 5.4e-17 61.9 7.1 3.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.1 EPA05746.1 - 8.3e-11 42.3 28.7 1.6e-10 41.4 10.2 4.2 2 2 0 2 2 2 1 AAA domain AAA_23 PF13476.1 EPA05746.1 - 0.00011 22.6 10.8 0.00011 22.6 7.5 2.6 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.22 EPA05746.1 - 0.0019 18.5 1.1 0.006 16.8 0.1 2.4 2 1 0 2 2 2 1 ABC transporter DUF2813 PF11398.3 EPA05746.1 - 0.0019 17.3 0.2 1.1 8.2 0.0 3.3 4 0 0 4 4 4 2 Protein of unknown function (DUF2813) AAA_29 PF13555.1 EPA05746.1 - 0.0022 17.4 0.1 0.016 14.7 0.0 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 EPA05746.1 - 0.072 13.0 0.0 0.22 11.4 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase A2M_N PF01835.14 EPA05748.1 - 3e-09 37.0 1.1 0.049 13.8 0.0 4.6 5 0 0 5 5 5 2 MG2 domain CarboxypepD_reg PF13620.1 EPA05748.1 - 0.0098 15.9 10.2 0.023 14.7 0.6 4.4 4 2 0 4 4 4 1 Carboxypeptidase regulatory-like domain YtkA PF13115.1 EPA05748.1 - 0.02 15.2 0.0 0.26 11.6 0.0 2.9 2 0 0 2 2 2 0 YtkA-like FlgD_ig PF13860.1 EPA05748.1 - 0.03 14.0 3.4 3.7 7.3 0.0 3.5 3 0 0 3 3 3 0 FlgD Ig-like domain Big_3_4 PF13754.1 EPA05748.1 - 0.14 12.5 12.8 0.27 11.5 0.2 4.7 4 1 0 4 4 4 0 Bacterial Ig-like domain (group 3) PNP_UDP_1 PF01048.15 EPA05749.1 - 3.6e-42 143.9 0.0 4.1e-42 143.7 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily zf-ribbon_3 PF13248.1 EPA05750.1 - 2e-05 23.6 14.1 0.00059 18.9 4.4 1.8 1 1 1 2 2 2 2 zinc-ribbon domain zinc_ribbon_2 PF13240.1 EPA05750.1 - 7.3e-05 22.1 5.9 0.0062 15.9 1.7 2.3 2 1 0 2 2 2 2 zinc-ribbon domain FYDLN_acid PF09538.5 EPA05750.1 - 0.0016 19.0 2.1 0.0017 18.8 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (FYDLN_acid) zf-C4_Topoisom PF01396.14 EPA05750.1 - 0.0018 17.7 7.7 0.18 11.3 1.0 2.3 2 0 0 2 2 2 2 Topoisomerase DNA binding C4 zinc finger zinc-ribbons_6 PF07191.7 EPA05750.1 - 0.012 15.3 6.6 0.37 10.6 4.0 1.9 1 1 1 2 2 2 0 zinc-ribbons DZR PF12773.2 EPA05750.1 - 0.015 15.0 7.2 0.056 13.2 5.1 1.5 1 1 0 1 1 1 0 Double zinc ribbon DUF2039 PF10217.4 EPA05750.1 - 0.015 15.2 3.9 0.016 15.2 2.7 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) Ogr_Delta PF04606.7 EPA05750.1 - 0.016 14.8 5.0 0.69 9.6 0.3 2.2 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger DNA_ligase_ZBD PF03119.11 EPA05750.1 - 0.017 14.8 1.0 0.48 10.1 0.1 2.3 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Prok-RING_1 PF14446.1 EPA05750.1 - 0.021 14.5 7.0 0.026 14.2 4.9 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-ISL3 PF14690.1 EPA05750.1 - 0.041 13.9 6.4 1.9 8.5 0.0 2.1 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 A2L_zn_ribbon PF08792.5 EPA05750.1 - 0.049 13.0 4.5 0.13 11.7 3.1 1.7 1 1 0 1 1 1 0 A2L zinc ribbon domain Zn_Tnp_IS91 PF14319.1 EPA05750.1 - 0.051 13.0 6.3 0.054 13.0 4.3 1.1 1 0 0 1 1 1 0 Transposase zinc-binding domain RPA_interact_C PF14768.1 EPA05750.1 - 0.058 13.7 4.2 0.061 13.7 2.9 1.0 1 0 0 1 1 1 0 Replication protein A interacting C-terminal OrfB_Zn_ribbon PF07282.6 EPA05750.1 - 0.071 12.7 5.7 0.086 12.5 3.9 1.1 1 0 0 1 1 1 0 Putative transposase DNA-binding domain GASA PF02704.9 EPA05750.1 - 0.089 12.7 5.1 0.11 12.4 3.5 1.2 1 0 0 1 1 1 0 Gibberellin regulated protein Zn_Tnp_IS1 PF03811.8 EPA05750.1 - 0.091 12.2 6.2 0.12 11.8 0.1 2.2 2 0 0 2 2 2 0 InsA N-terminal domain DUF555 PF04475.7 EPA05750.1 - 0.099 12.6 2.4 0.45 10.5 1.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF555) TF_Zn_Ribbon PF08271.7 EPA05750.1 - 0.12 11.6 6.6 0.2 11.0 4.5 1.4 1 1 0 1 1 1 0 TFIIB zinc-binding DUF1936 PF09151.5 EPA05750.1 - 0.14 11.6 5.2 3.7 7.1 1.5 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1936) zf-TFIIB PF13453.1 EPA05750.1 - 0.15 11.3 8.0 1 8.6 1.5 2.2 2 0 0 2 2 2 0 Transcription factor zinc-finger Zn_ribbon_recom PF13408.1 EPA05750.1 - 0.15 12.3 5.7 35 4.7 3.9 2.1 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain zinc_ribbon_5 PF13719.1 EPA05750.1 - 0.17 11.4 4.6 1.6 8.3 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain YhfH PF14149.1 EPA05750.1 - 0.18 11.6 4.5 4.7 7.0 2.6 2.1 1 1 1 2 2 2 0 YhfH-like protein Ribosomal_S27e PF01667.12 EPA05750.1 - 0.19 11.3 5.5 0.3 10.6 3.8 1.4 1 1 0 1 1 1 0 Ribosomal protein S27 Mu-like_Com PF10122.4 EPA05750.1 - 0.2 10.7 7.6 0.29 10.2 1.2 2.1 1 1 1 2 2 2 0 Mu-like prophage protein Com Cys_rich_KTR PF14205.1 EPA05750.1 - 0.28 10.6 7.7 13 5.3 5.3 2.1 1 1 0 1 1 1 0 Cysteine-rich KTR IBR PF01485.16 EPA05750.1 - 0.31 10.9 6.3 0.35 10.7 4.4 1.2 1 0 0 1 1 1 0 IBR domain zf-NADH-PPase PF09297.6 EPA05750.1 - 0.32 10.5 7.2 0.48 9.9 1.9 2.2 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Zn-ribbon_8 PF09723.5 EPA05750.1 - 0.36 10.8 8.0 1.8 8.6 0.3 2.3 1 1 1 2 2 2 0 Zinc ribbon domain HypA PF01155.14 EPA05750.1 - 0.38 10.4 4.9 0.42 10.3 3.4 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Nudix_N_2 PF14803.1 EPA05750.1 - 0.51 10.0 4.4 0.63 9.7 0.7 2.2 2 0 0 2 2 2 0 Nudix N-terminal DUF2072 PF09845.4 EPA05750.1 - 0.51 10.2 3.0 0.57 10.1 2.0 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) zf-Mss51 PF13824.1 EPA05750.1 - 0.53 10.1 5.3 0.76 9.6 3.7 1.3 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-FPG_IleRS PF06827.9 EPA05750.1 - 0.64 9.7 9.2 3.3 7.4 5.9 2.1 1 1 1 2 2 2 0 Zinc finger found in FPG and IleRS DUF329 PF03884.9 EPA05750.1 - 0.66 9.5 7.3 3.8 7.1 1.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF329) GFA PF04828.9 EPA05750.1 - 0.72 9.8 5.8 0.23 11.4 0.8 1.9 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-HIT PF04438.11 EPA05750.1 - 0.72 9.5 9.0 2.1 8.0 0.4 2.3 2 1 0 2 2 2 0 HIT zinc finger RNA_POL_M_15KD PF02150.11 EPA05750.1 - 0.75 9.5 9.8 0.18 11.4 1.0 2.3 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit zinc_ribbon_4 PF13717.1 EPA05750.1 - 0.81 9.4 7.0 1.4 8.6 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain NOB1_Zn_bind PF08772.6 EPA05750.1 - 0.82 9.5 7.2 1.8 8.4 5.1 1.6 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Dynactin_p62 PF05502.8 EPA05750.1 - 0.9 8.2 3.6 0.92 8.1 2.5 1.0 1 0 0 1 1 1 0 Dynactin p62 family Rubredoxin PF00301.15 EPA05750.1 - 0.92 9.4 5.7 13 5.8 0.1 2.2 2 0 0 2 2 2 0 Rubredoxin zf-RING_3 PF14369.1 EPA05750.1 - 0.97 9.4 6.6 1.3 9.0 0.1 2.4 1 1 1 2 2 2 0 zinc-finger Cys_rich_CWC PF14375.1 EPA05750.1 - 1 9.3 7.6 0.46 10.4 0.6 2.2 2 0 0 2 2 2 0 Cysteine-rich CWC Rep_fac-A_C PF08646.5 EPA05750.1 - 1.1 8.9 6.0 1.1 8.9 4.2 1.0 1 0 0 1 1 1 0 Replication factor-A C terminal domain TFIIS_C PF01096.13 EPA05750.1 - 1.1 8.9 8.0 3 7.5 0.8 2.4 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-HYPF PF07503.7 EPA05750.1 - 1.4 8.3 5.8 67 3.0 4.0 2.2 1 1 0 1 1 1 0 HypF finger Zn_Tnp_IS1595 PF12760.2 EPA05750.1 - 2.2 8.1 9.1 3.5 7.4 0.7 2.2 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-IS66 PF13005.2 EPA05750.1 - 2.5 8.1 8.3 5.5 7.0 0.6 2.1 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 DUF2082 PF09855.4 EPA05750.1 - 3.4 7.5 7.3 4.8 7.1 0.6 2.1 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-Di19 PF05605.7 EPA05750.1 - 3.5 7.8 7.9 1.5 9.0 0.8 2.0 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Lar_restr_allev PF14354.1 EPA05750.1 - 3.9 7.8 7.2 17 5.7 5.0 1.8 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-LITAF-like PF10601.4 EPA05750.1 - 4.9 7.0 8.3 10 6.0 0.3 2.1 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain zf-tcix PF14952.1 EPA05750.1 - 5.9 6.3 7.2 2.3 7.6 0.6 2.3 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding PhnA_Zn_Ribbon PF08274.7 EPA05750.1 - 7.1 6.5 8.2 57 3.6 5.7 2.1 1 1 0 1 1 1 0 PhnA Zinc-Ribbon CpXC PF14353.1 EPA05750.1 - 9.4 6.2 7.0 23 4.9 0.6 2.0 1 1 0 2 2 2 0 CpXC protein zinc_ribbon_4 PF13717.1 EPA05751.1 - 6.8e-05 22.4 3.4 0.00022 20.8 2.3 1.8 1 1 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_5 PF13719.1 EPA05751.1 - 0.0001 21.8 3.7 0.00029 20.3 2.5 1.7 1 1 0 1 1 1 1 zinc-ribbon domain IBR PF01485.16 EPA05751.1 - 0.0014 18.4 1.2 0.0023 17.7 0.8 1.3 1 0 0 1 1 1 1 IBR domain OrfB_Zn_ribbon PF07282.6 EPA05751.1 - 0.0034 16.9 0.3 0.0045 16.6 0.2 1.2 1 0 0 1 1 1 1 Putative transposase DNA-binding domain CpXC PF14353.1 EPA05751.1 - 0.0044 16.9 3.5 0.0064 16.4 0.1 2.0 1 1 1 2 2 2 1 CpXC protein zf-ribbon_3 PF13248.1 EPA05751.1 - 0.0091 15.1 4.1 0.098 11.9 3.2 2.0 1 1 1 2 2 2 2 zinc-ribbon domain zf-ISL3 PF14690.1 EPA05751.1 - 0.01 15.8 1.9 2.2 8.4 0.1 2.1 1 1 1 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 PhnA_Zn_Ribbon PF08274.7 EPA05751.1 - 0.013 15.2 1.5 0.43 10.3 0.1 2.2 2 0 0 2 2 2 0 PhnA Zinc-Ribbon Zn_Tnp_IS1595 PF12760.2 EPA05751.1 - 0.015 15.0 0.2 2.1 8.2 0.0 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Zn_Tnp_IS91 PF14319.1 EPA05751.1 - 0.016 14.6 0.1 0.018 14.5 0.1 1.0 1 0 0 1 1 1 0 Transposase zinc-binding domain Zn_Tnp_IS1 PF03811.8 EPA05751.1 - 0.021 14.2 2.4 0.84 9.1 0.2 2.1 2 0 0 2 2 2 0 InsA N-terminal domain Prok-RING_1 PF14446.1 EPA05751.1 - 0.028 14.1 2.2 0.036 13.8 1.5 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-C2H2_4 PF13894.1 EPA05751.1 - 0.048 14.0 0.6 5.1 7.6 0.0 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger DUF2387 PF09526.5 EPA05751.1 - 0.05 13.5 2.6 0.085 12.7 1.8 1.4 1 1 0 1 1 1 0 Probable metal-binding protein (DUF2387) Ribosomal_S27e PF01667.12 EPA05751.1 - 0.059 12.9 3.0 0.21 11.1 2.1 1.7 1 1 0 1 1 1 0 Ribosomal protein S27 DUF329 PF03884.9 EPA05751.1 - 0.061 12.8 3.8 3.2 7.3 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF329) HypA PF01155.14 EPA05751.1 - 0.065 12.9 0.2 0.068 12.8 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family DZR PF12773.2 EPA05751.1 - 0.084 12.7 1.8 0.18 11.6 1.2 1.5 1 1 0 1 1 1 0 Double zinc ribbon RIG-I_C-RD PF11648.3 EPA05751.1 - 0.12 12.2 0.4 0.14 12.0 0.2 1.0 1 0 0 1 1 1 0 C-terminal domain of RIG-I Ogr_Delta PF04606.7 EPA05751.1 - 0.14 11.8 0.7 14 5.4 0.1 2.1 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Mu-like_Com PF10122.4 EPA05751.1 - 0.22 10.5 2.6 0.5 9.4 1.8 1.6 1 1 0 1 1 1 0 Mu-like prophage protein Com zf-H2C2_2 PF13465.1 EPA05751.1 - 0.23 11.8 4.2 4.1 7.8 0.2 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zinc-ribbons_6 PF07191.7 EPA05751.1 - 0.27 11.0 2.2 0.38 10.5 1.5 1.4 1 1 0 1 1 1 0 zinc-ribbons zf-C4_Topoisom PF01396.14 EPA05751.1 - 0.3 10.6 2.5 9.4 5.8 0.2 2.1 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger UPF0547 PF10571.4 EPA05751.1 - 0.32 10.7 8.2 1.6 8.4 5.7 1.9 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-BED PF02892.10 EPA05751.1 - 0.48 10.2 2.4 2.3 8.0 0.0 2.1 1 1 1 2 2 2 0 BED zinc finger Auto_anti-p27 PF06677.7 EPA05751.1 - 0.52 10.1 2.4 0.72 9.6 1.6 1.3 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF35_N PF12172.3 EPA05751.1 - 0.61 10.0 2.5 10 6.1 0.1 2.1 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-Di19 PF05605.7 EPA05751.1 - 0.68 10.1 4.4 1.5 9.0 0.5 2.1 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.5 EPA05751.1 - 0.83 9.6 6.1 12 5.9 4.2 2.2 1 1 0 1 1 1 0 Zinc ribbon domain zf-RING_3 PF14369.1 EPA05751.1 - 1.3 9.0 6.4 0.68 9.9 0.4 2.1 1 1 1 2 2 2 0 zinc-finger zf-HIT PF04438.11 EPA05751.1 - 1.3 8.6 4.2 8.7 6.0 0.1 2.2 2 0 0 2 2 2 0 HIT zinc finger zf-H2C2_5 PF13909.1 EPA05751.1 - 1.6 9.1 4.8 0.99 9.7 0.3 2.1 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-RING_4 PF14570.1 EPA05751.1 - 3.4 7.3 7.4 31 4.2 1.1 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zinc_ribbon_2 PF13240.1 EPA05751.1 - 4.3 6.9 9.3 26 4.4 6.4 2.0 1 1 0 1 1 1 0 zinc-ribbon domain Ribosomal_S6e PF01092.14 EPA05752.1 - 4.8e-19 68.2 0.1 5.9e-19 67.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S6e GTP_EFTU PF00009.22 EPA05753.1 - 7.7e-10 38.5 0.6 1.7e-09 37.4 0.4 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EPA05753.1 - 0.035 14.0 0.0 0.038 13.9 0.0 1.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase FeoB_N PF02421.13 EPA05753.1 - 0.079 12.2 0.0 0.085 12.1 0.0 1.1 1 0 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.4 EPA05753.1 - 0.09 12.2 0.0 0.098 12.1 0.0 1.1 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Adenylsucc_synt PF00709.16 EPA05754.1 - 0.0061 15.2 0.4 0.0067 15.1 0.3 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Sec5 PF15469.1 EPA05754.1 - 0.049 13.3 1.0 0.055 13.1 0.7 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec5 FlaC_arch PF05377.6 EPA05754.1 - 0.074 12.9 3.2 0.68 9.8 0.3 2.1 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Flu_NS2 PF00601.14 EPA05754.1 - 0.16 12.1 1.0 0.22 11.7 0.7 1.1 1 0 0 1 1 1 0 Influenza non-structural protein (NS2) ATP-synt_B PF00430.13 EPA05754.1 - 0.17 11.6 1.3 0.18 11.5 0.9 1.0 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) SIMPL PF04402.9 EPA05755.1 - 2.9e-45 154.7 3.9 3.4e-45 154.4 2.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) MFS_1 PF07690.11 EPA05756.1 - 4.9e-49 166.9 77.1 4e-45 154.0 32.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EPA05756.1 - 1.5e-11 43.5 9.7 1.5e-11 43.5 6.7 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EPA05756.1 - 0.0014 16.9 12.6 0.0014 16.9 8.7 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF1523 PF07509.6 EPA05756.1 - 0.03 13.5 0.3 0.089 12.0 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1523) MFS_2 PF13347.1 EPA05756.1 - 0.19 10.1 40.6 0.013 13.9 4.8 3.7 1 1 1 3 3 3 0 MFS/sugar transport protein STT3 PF02516.9 EPA05757.1 - 5.3e-25 88.3 38.0 2e-24 86.4 26.3 1.7 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit STT3 PF02516.9 EPA05758.1 - 6.5e-07 28.6 0.1 8.2e-07 28.3 0.1 1.2 1 0 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit Dpy19 PF10034.4 EPA05758.1 - 0.059 11.5 0.0 0.072 11.2 0.0 1.2 1 0 0 1 1 1 0 Q-cell neuroblast polarisation TSP_3 PF02412.13 EPA05760.1 - 6.3e-05 22.3 1.8 0.00013 21.3 1.3 1.5 1 0 0 1 1 1 1 Thrombospondin type 3 repeat Cupredoxin_1 PF13473.1 EPA05760.1 - 0.0032 17.3 0.0 0.0055 16.5 0.0 1.6 1 1 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.15 EPA05760.1 - 0.047 13.9 0.0 0.096 12.9 0.0 1.6 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family DNA_binding_1 PF01035.15 EPA05761.1 - 6.8e-30 102.6 0.0 7.8e-30 102.4 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain SecE PF00584.15 EPA05762.1 - 0.00045 19.7 0.0 0.0005 19.5 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Frag1 PF10277.4 EPA05762.1 - 0.027 13.9 0.0 0.028 13.8 0.0 1.0 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family Ribosomal_L32e PF01655.13 EPA05763.1 - 6.4e-34 116.3 0.1 7.7e-34 116.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Spt5-NGN PF03439.8 EPA05764.1 - 4.4e-20 71.2 0.0 6.8e-20 70.6 0.0 1.3 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.24 EPA05764.1 - 3.1e-06 26.6 0.2 6.8e-06 25.5 0.2 1.6 1 0 0 1 1 1 1 KOW motif NusG PF02357.14 EPA05764.1 - 0.018 15.2 0.0 0.059 13.6 0.0 1.8 1 1 0 1 1 1 0 Transcription termination factor nusG Ribosomal_L11_N PF03946.9 EPA05765.1 - 2.2e-24 84.6 0.8 4.7e-24 83.6 0.5 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 EPA05765.1 - 4.7e-21 74.7 1.3 9.3e-21 73.7 0.9 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain SBP_bac_5 PF00496.17 EPA05765.1 - 0.012 14.4 0.0 0.015 14.1 0.0 1.1 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle Hom_end PF05204.9 EPA05765.1 - 0.089 12.7 0.3 0.14 12.1 0.2 1.3 1 0 0 1 1 1 0 Homing endonuclease PEPCK_ATP PF01293.15 EPA05766.1 - 1.7e-219 729.1 0.0 2e-219 728.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase tRNA_deacylase PF04414.7 EPA05767.1 - 1.6e-59 200.5 0.0 1.9e-59 200.3 0.0 1.0 1 0 0 1 1 1 1 D-aminoacyl-tRNA deacylase Syd PF07348.7 EPA05767.1 - 0.11 11.8 0.1 1.5 8.1 0.0 2.1 1 1 1 2 2 2 0 Syd protein (SUKH-2) Peptidase_S8 PF00082.17 EPA05768.1 - 9.8e-34 116.7 0.0 1.6e-33 116.1 0.0 1.3 1 0 0 1 1 1 1 Subtilase family PA PF02225.17 EPA05768.1 - 5e-11 42.1 0.1 7.6e-10 38.3 0.0 2.6 2 1 0 2 2 2 1 PA domain Ribosomal_L19e PF01280.15 EPA05769.1 - 2.8e-41 140.7 10.2 3.3e-41 140.5 7.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L19e Fe_hyd_SSU PF02256.12 EPA05769.1 - 0.0082 16.1 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Iron hydrogenase small subunit DUF95 PF01944.12 EPA05770.1 - 2.7e-07 30.3 15.0 3e-07 30.2 10.4 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF95 NIR_SIR_ferr PF03460.12 EPA05771.1 - 7.1e-17 60.7 0.0 1.1e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Thi4 PF01946.12 EPA05774.1 - 9.2e-64 214.6 0.2 1.1e-63 214.3 0.1 1.1 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.19 EPA05774.1 - 2.9e-15 56.0 0.2 8.6e-07 28.1 0.0 2.9 2 1 1 3 3 3 2 FAD binding domain FAD_oxidored PF12831.2 EPA05774.1 - 2.1e-11 43.5 0.0 3.1e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.19 EPA05774.1 - 1.1e-09 37.7 0.2 3e-05 23.1 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EPA05774.1 - 1.9e-07 30.9 0.0 4.1e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EPA05774.1 - 3e-07 30.5 0.0 5.1e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EPA05774.1 - 2.4e-06 26.3 0.0 3.4e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.14 EPA05774.1 - 2.8e-06 26.6 0.0 4.6e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.7 EPA05774.1 - 1.2e-05 24.3 0.2 0.00015 20.7 0.1 2.0 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.1 EPA05774.1 - 0.00018 21.6 0.1 0.00032 20.8 0.0 1.5 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EPA05774.1 - 0.00024 20.0 0.1 0.00041 19.3 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.9 EPA05774.1 - 0.0033 16.1 0.0 1 7.8 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_9 PF13454.1 EPA05774.1 - 0.0089 15.8 0.1 0.02 14.6 0.1 1.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding Amino_oxidase PF01593.19 EPA05774.1 - 0.021 13.9 0.0 0.032 13.3 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase GDI PF00996.13 EPA05774.1 - 0.021 13.1 0.0 0.036 12.3 0.0 1.3 1 0 0 1 1 1 0 GDP dissociation inhibitor Pyr_redox PF00070.22 EPA05774.1 - 0.03 14.7 0.2 0.11 12.8 0.0 2.1 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase CPSase_L_chain PF00289.17 EPA05774.1 - 0.1 12.7 0.0 0.47 10.5 0.0 2.1 3 0 0 3 3 3 0 Carbamoyl-phosphate synthase L chain, N-terminal domain Mei5 PF10376.4 EPA05776.1 - 0.0011 18.5 10.8 0.045 13.2 2.3 2.2 2 0 0 2 2 2 2 Double-strand recombination repair protein DUF2036 PF09724.4 EPA05776.1 - 0.026 13.6 1.6 0.073 12.1 0.4 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2036) Polysacc_synt_2 PF02719.10 EPA05776.1 - 0.029 13.2 0.0 0.88 8.4 0.0 2.5 2 1 0 2 2 2 0 Polysaccharide biosynthesis protein Pilin PF00114.14 EPA05776.1 - 1.1 10.0 6.2 2.1 9.1 0.6 2.7 3 0 0 3 3 3 0 Pilin (bacterial filament) FlxA PF14282.1 EPA05776.1 - 1.8 8.5 19.7 3.3 7.6 0.4 3.3 2 1 1 3 3 3 0 FlxA-like protein FlgM PF04316.8 EPA05776.1 - 2.2 8.3 6.5 8.2 6.4 1.4 2.7 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM CBS PF00571.23 EPA05777.1 - 9.1e-27 92.5 1.7 1.9e-14 53.1 0.2 2.1 2 0 0 2 2 2 2 CBS domain PcrB PF01884.12 EPA05777.1 - 0.029 13.6 0.8 0.053 12.7 0.6 1.6 1 1 0 1 1 1 0 PcrB family Med9 PF07544.8 EPA05778.1 - 0.00012 21.7 10.6 0.53 10.0 1.4 3.8 2 2 1 3 3 3 2 RNA polymerase II transcription mediator complex subunit 9 ATG16 PF08614.6 EPA05778.1 - 0.00053 19.8 8.9 0.12 12.1 1.0 2.3 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) TBPIP PF07106.8 EPA05778.1 - 0.0019 17.7 12.0 0.11 11.9 0.4 2.8 2 1 0 2 2 2 2 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Prefoldin_2 PF01920.15 EPA05778.1 - 0.0028 17.3 10.4 0.18 11.5 0.5 4.2 3 1 1 4 4 4 1 Prefoldin subunit DUF848 PF05852.6 EPA05778.1 - 0.0066 16.3 7.0 0.17 11.7 1.5 2.4 2 0 0 2 2 2 1 Gammaherpesvirus protein of unknown function (DUF848) Spectrin PF00435.16 EPA05778.1 - 0.0089 16.3 1.1 0.81 10.0 0.1 2.6 2 0 0 2 2 2 1 Spectrin repeat IncA PF04156.9 EPA05778.1 - 0.016 14.8 10.2 1.2 8.6 3.5 2.6 2 1 0 2 2 2 0 IncA protein DUF2884 PF11101.3 EPA05778.1 - 0.017 14.4 1.2 0.53 9.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) HlyD PF00529.15 EPA05778.1 - 0.027 13.8 3.3 1.1 8.5 0.7 2.2 2 0 0 2 2 2 0 HlyD family secretion protein Snapin_Pallidin PF14712.1 EPA05778.1 - 0.027 14.7 7.4 0.41 10.9 0.3 2.7 2 0 0 2 2 2 0 Snapin/Pallidin Filament PF00038.16 EPA05778.1 - 0.031 13.7 5.6 0.75 9.2 0.4 2.3 2 0 0 2 2 2 0 Intermediate filament protein DUF4391 PF14335.1 EPA05778.1 - 0.034 13.5 0.6 0.034 13.5 0.4 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4391) DUF4094 PF13334.1 EPA05778.1 - 0.039 14.3 8.4 2.3 8.6 0.1 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) DUF1192 PF06698.6 EPA05778.1 - 0.039 13.7 4.6 17 5.3 0.2 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) HSBP1 PF06825.7 EPA05778.1 - 0.04 13.4 0.9 0.36 10.4 0.2 2.4 2 0 0 2 2 2 0 Heat shock factor binding protein 1 DUF4140 PF13600.1 EPA05778.1 - 0.043 14.2 8.3 1.1 9.7 0.6 3.7 2 2 2 4 4 4 0 N-terminal domain of unknown function (DUF4140) Laminin_II PF06009.7 EPA05778.1 - 0.056 13.2 12.8 0.56 9.9 1.4 2.7 2 1 0 2 2 2 0 Laminin Domain II ApoO PF09769.4 EPA05778.1 - 0.06 13.0 2.5 0.094 12.4 0.4 2.0 2 0 0 2 2 2 0 Apolipoprotein O FlaC_arch PF05377.6 EPA05778.1 - 0.061 13.2 10.6 0.89 9.4 0.7 3.6 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.7 EPA05778.1 - 0.07 12.9 8.9 1.2 8.9 1.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Saf-Nte_pilin PF09460.5 EPA05778.1 - 0.078 12.7 2.5 4.5 7.0 0.2 2.4 2 0 0 2 2 2 0 Saf-pilin pilus formation protein Tropomyosin_1 PF12718.2 EPA05778.1 - 0.084 12.7 10.6 0.18 11.6 0.1 2.9 2 2 1 3 3 3 0 Tropomyosin like DUF1993 PF09351.5 EPA05778.1 - 0.12 12.3 2.4 1.4 8.8 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF1993) ACCA PF03255.9 EPA05778.1 - 0.2 11.1 5.7 7.4 6.1 1.0 2.9 2 1 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit FlgN PF05130.7 EPA05778.1 - 0.22 11.7 5.1 5.4 7.2 0.2 2.3 2 0 0 2 2 2 0 FlgN protein WEMBL PF05701.6 EPA05778.1 - 0.25 9.7 8.9 0.44 8.9 0.9 2.2 2 0 0 2 2 2 0 Weak chloroplast movement under blue light Phage_HK97_TLTM PF06120.6 EPA05778.1 - 0.36 10.1 6.7 0.89 8.8 0.8 2.3 2 0 0 2 2 2 0 Tail length tape measure protein T4SS PF07996.6 EPA05778.1 - 0.44 10.3 9.8 3.2 7.5 0.9 2.6 2 1 0 2 2 2 0 Type IV secretion system proteins NPV_P10 PF05531.7 EPA05778.1 - 0.45 10.7 11.2 1 9.6 0.4 3.4 3 1 0 3 3 2 0 Nucleopolyhedrovirus P10 protein DUF972 PF06156.8 EPA05778.1 - 0.61 10.4 9.2 1.2 9.5 1.5 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF972) TPR_MLP1_2 PF07926.7 EPA05778.1 - 1.1 8.9 11.4 8.3 6.1 1.4 3.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Phage_GP20 PF06810.6 EPA05778.1 - 1.2 8.5 10.2 0.35 10.2 1.1 2.9 2 1 1 3 3 3 0 Phage minor structural protein GP20 DUF1515 PF07439.6 EPA05778.1 - 1.2 8.9 4.0 2.1 8.2 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1515) Baculo_PEP_C PF04513.7 EPA05778.1 - 1.2 8.9 12.8 3.9 7.2 2.8 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Seryl_tRNA_N PF02403.17 EPA05778.1 - 1.9 8.5 12.9 4.9 7.2 2.4 3.4 2 2 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Syntaxin-6_N PF09177.6 EPA05778.1 - 1.9 8.9 9.8 6.6 7.2 0.7 3.1 2 2 1 3 3 3 0 Syntaxin 6, N-terminal Shugoshin_N PF07558.6 EPA05778.1 - 2.7 7.7 7.5 9.9 5.9 0.2 3.5 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region Prefoldin PF02996.12 EPA05778.1 - 2.7 7.6 11.7 4 7.1 0.5 4.0 3 1 1 4 4 4 0 Prefoldin subunit ORF6C PF10552.4 EPA05778.1 - 2.8 7.7 7.3 17 5.2 0.6 3.3 2 2 1 3 3 3 0 ORF6C domain LUC7 PF03194.10 EPA05778.1 - 2.9 7.3 6.2 3.4 7.1 0.7 2.2 2 0 0 2 2 2 0 LUC7 N_terminus TMF_DNA_bd PF12329.3 EPA05778.1 - 3.7 7.4 17.6 4.5 7.1 1.3 4.1 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding HR1 PF02185.11 EPA05778.1 - 6.1 6.6 12.8 6.2 6.6 0.5 3.6 3 1 1 4 4 4 0 Hr1 repeat Lectin_N PF03954.9 EPA05778.1 - 7.8 5.8 8.9 4.8 6.5 0.3 2.7 2 2 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF4200 PF13863.1 EPA05778.1 - 9.6 6.1 15.4 8.5 6.3 0.2 4.1 2 2 1 4 4 4 0 Domain of unknown function (DUF4200) DUF3172 PF11371.3 EPA05780.1 - 0.0068 15.9 0.1 0.01 15.3 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3172) Dopey_N PF04118.9 EPA05780.1 - 0.047 12.4 1.1 0.063 12.0 0.5 1.3 1 1 0 1 1 1 0 Dopey, N-terminal DUF2683 PF10884.3 EPA05780.1 - 0.098 12.6 1.3 2.6 8.0 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2683) Cupin_4 PF08007.7 EPA05780.1 - 0.27 10.4 8.0 0.46 9.6 5.6 1.5 1 1 0 1 1 1 0 Cupin superfamily protein ComX PF05952.7 EPA05780.1 - 0.38 10.2 0.0 0.38 10.2 0.0 3.0 3 1 0 3 3 3 0 Bacillus competence pheromone ComX Mmp37 PF09139.6 EPA05780.1 - 2.7 6.9 11.7 1 8.2 6.1 1.6 1 1 0 1 1 1 0 Mitochondrial matrix Mmp37 ATP-synt_C PF00137.16 EPA05780.1 - 6.1 6.8 7.1 55 3.7 1.2 3.4 3 2 1 4 4 4 0 ATP synthase subunit C GSDH PF07995.6 EPA05781.1 - 5.6e-75 252.4 0.1 6.6e-75 252.2 0.1 1.0 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Proteasome_A_N PF10584.4 EPA05781.1 - 0.0013 17.9 1.1 0.085 12.1 0.1 2.7 2 0 0 2 2 2 2 Proteasome subunit A N-terminal signature SGL PF08450.7 EPA05781.1 - 0.059 12.7 0.0 7.7 5.8 0.0 2.3 2 0 0 2 2 2 0 SMP-30/Gluconolaconase/LRE-like region PD40 PF07676.7 EPA05781.1 - 0.17 11.6 1.6 2.1 8.1 0.0 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Cytochrom_NNT PF03264.9 EPA05782.1 - 0.0072 15.7 0.9 0.0078 15.6 0.6 1.0 1 0 0 1 1 1 1 NapC/NirT cytochrome c family, N-terminal region DNA_RNApol_7kD PF03604.8 EPA05782.1 - 0.043 13.2 1.4 0.043 13.2 0.9 2.1 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Rep_fac-A_C PF08646.5 EPA05782.1 - 0.06 13.0 7.0 0.073 12.7 4.9 1.3 1 1 0 1 1 1 0 Replication factor-A C terminal domain DUF2318 PF10080.4 EPA05782.1 - 0.099 12.4 1.3 0.12 12.1 0.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) zinc-ribbons_6 PF07191.7 EPA05782.1 - 0.24 11.1 3.4 0.3 10.9 2.4 1.1 1 0 0 1 1 1 0 zinc-ribbons DZR PF12773.2 EPA05782.1 - 0.3 10.9 8.8 0.49 10.2 6.1 1.4 1 1 0 1 1 1 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.6 EPA05782.1 - 0.7 9.5 8.8 0.032 13.8 2.2 1.6 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zf-RanBP PF00641.13 EPA05782.1 - 0.91 8.6 10.0 0.064 12.3 2.6 2.2 2 1 0 2 2 2 0 Zn-finger in Ran binding protein and others A2L_zn_ribbon PF08792.5 EPA05782.1 - 2.1 7.8 11.4 5.5 6.5 0.9 3.1 2 1 1 3 3 3 0 A2L zinc ribbon domain Response_reg PF00072.19 EPA05783.1 - 4.5e-23 81.3 0.6 5.2e-23 81.1 0.4 1.0 1 0 0 1 1 1 1 Response regulator receiver domain LMWPc PF01451.16 EPA05784.1 - 1.5e-28 99.8 0.1 1.7e-28 99.6 0.1 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase ADH_N PF08240.7 EPA05785.1 - 0.0004 20.1 0.0 0.00062 19.4 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AAA_PrkA PF08298.6 EPA05785.1 - 0.0095 14.6 0.1 0.01 14.5 0.1 1.0 1 0 0 1 1 1 1 PrkA AAA domain ABC_tran PF00005.22 EPA05786.1 - 4e-17 62.8 0.1 5.2e-10 39.7 0.0 3.2 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EPA05786.1 - 2.5e-10 40.8 2.5 0.0023 17.9 0.0 3.4 3 0 0 3 3 3 2 AAA domain SMC_N PF02463.14 EPA05786.1 - 2.9e-08 33.2 0.3 0.082 12.1 0.0 3.1 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain DnaJ_CXXCXGXG PF00684.14 EPA05786.1 - 1.7e-05 24.7 1.9 0.0015 18.5 0.4 2.3 2 0 0 2 2 2 1 DnaJ central domain MMR_HSR1 PF01926.18 EPA05786.1 - 0.00032 20.6 0.3 0.0054 16.6 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.1 EPA05786.1 - 0.0018 18.2 0.0 0.0058 16.6 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 EPA05786.1 - 0.0027 16.9 1.0 0.004 16.3 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 EPA05786.1 - 0.0054 16.2 0.1 0.013 14.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 EPA05786.1 - 0.0083 15.2 2.6 3 6.8 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain Viral_helicase1 PF01443.13 EPA05786.1 - 0.0086 15.6 0.1 0.024 14.1 0.0 1.8 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase MobB PF03205.9 EPA05786.1 - 0.0093 15.6 0.1 0.027 14.1 0.1 1.8 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B NB-ARC PF00931.17 EPA05786.1 - 0.011 14.6 0.1 0.17 10.7 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_22 PF13401.1 EPA05786.1 - 0.014 15.5 0.7 0.23 11.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_14 PF13173.1 EPA05786.1 - 0.018 14.9 0.1 0.36 10.7 0.0 2.9 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.1 EPA05786.1 - 0.02 14.3 0.1 1.2 8.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_10 PF12846.2 EPA05786.1 - 0.025 14.0 0.0 0.071 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA-like domain Arch_ATPase PF01637.13 EPA05786.1 - 0.041 13.5 0.0 0.11 12.1 0.0 1.8 1 0 0 1 1 1 0 Archaeal ATPase AAA_33 PF13671.1 EPA05786.1 - 0.044 13.6 0.0 0.33 10.8 0.0 2.5 3 0 0 3 3 3 0 AAA domain DUF2972 PF11186.3 EPA05786.1 - 0.046 13.6 0.3 0.13 12.1 0.0 1.9 2 0 0 2 2 1 0 Protein of unknown function (DUF2972) AAA_17 PF13207.1 EPA05786.1 - 0.053 14.3 0.7 0.41 11.4 0.0 2.8 2 1 0 2 2 2 0 AAA domain ArgK PF03308.11 EPA05786.1 - 0.086 11.5 0.1 0.27 9.9 0.0 1.8 2 0 0 2 2 2 0 ArgK protein SbcCD_C PF13558.1 EPA05786.1 - 0.092 12.6 0.9 19 5.2 0.0 3.5 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit PRK PF00485.13 EPA05786.1 - 0.12 11.8 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family GIY-YIG PF01541.19 EPA05788.1 - 1.1e-13 51.3 1.3 1.5e-13 50.8 0.9 1.1 1 0 0 1 1 1 1 GIY-YIG catalytic domain PurA PF04845.8 EPA05788.1 - 0.021 13.9 0.4 0.025 13.6 0.3 1.2 1 0 0 1 1 1 0 PurA ssDNA and RNA-binding protein HemolysinCabind PF00353.14 EPA05789.1 - 3.5e-20 70.3 95.6 0.00067 19.8 2.4 9.1 4 1 9 13 13 13 13 Hemolysin-type calcium-binding repeat (2 copies) tRNA-synt_2b PF00587.20 EPA05790.1 - 4.2e-48 163.1 0.1 9.6e-48 162.0 0.1 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EPA05790.1 - 1.9e-16 59.7 0.3 5.1e-16 58.3 0.1 1.8 2 0 0 2 2 2 1 Anticodon binding domain Zn-ribbon_8 PF09723.5 EPA05790.1 - 0.082 12.8 0.2 23 5.0 0.0 2.7 2 0 0 2 2 2 0 Zinc ribbon domain zinc_ribbon_5 PF13719.1 EPA05790.1 - 0.13 11.9 3.5 3.6 7.2 0.3 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA05790.1 - 0.14 11.9 2.7 6 6.6 0.2 2.7 2 0 0 2 2 2 0 zinc-ribbon domain AP_endonuc_2 PF01261.19 EPA05792.1 - 2.6e-31 108.5 0.0 5.8e-31 107.4 0.0 1.5 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel DUF3445 PF11927.3 EPA05792.1 - 0.098 12.0 0.0 0.18 11.1 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3445) EF-hand_1 PF00036.27 EPA05794.1 - 2.5 7.5 4.6 5 6.6 0.1 3.1 3 0 0 3 3 3 0 EF hand CbiD PF01888.12 EPA05796.1 - 4.6e-08 32.3 0.2 9.8e-08 31.2 0.2 1.6 1 0 0 1 1 1 1 CbiD DUF3473 PF11959.3 EPA05797.1 - 2.6e-31 107.8 0.0 2.9e-31 107.6 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3473) Hydrolase_like PF13242.1 EPA05798.1 - 0.0022 17.6 0.0 0.0051 16.4 0.0 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.1 EPA05798.1 - 0.0032 17.7 0.0 0.0071 16.5 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Smr PF01713.16 EPA05798.1 - 0.059 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Smr domain PMBR PF09373.5 EPA05798.1 - 0.16 12.0 0.3 0.85 9.6 0.1 2.3 2 0 0 2 2 2 0 Pseudomurein-binding repeat IGPD PF00475.13 EPA05799.1 - 1.1e-13 51.2 1.9 2e-13 50.4 1.1 1.5 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase PEPCK_ATP PF01293.15 EPA05799.1 - 0.11 10.9 0.2 0.11 11.0 0.2 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase Snf7 PF03357.16 EPA05800.1 - 0.047 13.0 2.5 0.11 11.8 1.7 1.7 1 1 0 1 1 1 0 Snf7 SHR3_chaperone PF08229.6 EPA05801.1 - 0.092 11.6 0.6 1.1 8.2 0.1 2.1 2 0 0 2 2 2 0 ER membrane protein SH3 NVEALA PF14055.1 EPA05801.1 - 0.21 11.3 0.9 0.45 10.2 0.6 1.5 1 0 0 1 1 1 0 NVEALA protein DUF16 PF01519.11 EPA05801.1 - 0.21 11.7 0.1 0.21 11.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF1083 PF06452.6 EPA05803.1 - 0.07 12.9 0.4 0.11 12.4 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1083) TP_methylase PF00590.15 EPA05804.1 - 2e-43 148.5 0.1 2.4e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Aldolase PF01081.14 EPA05804.1 - 0.01 15.0 0.1 0.021 13.9 0.1 1.5 1 0 0 1 1 1 0 KDPG and KHG aldolase Radical_SAM PF04055.16 EPA05804.1 - 0.034 14.3 0.1 0.07 13.3 0.1 1.6 1 1 0 1 1 1 0 Radical SAM superfamily PrpR_N PF06506.6 EPA05804.1 - 0.057 12.8 0.6 0.57 9.5 0.0 2.3 2 1 0 2 2 2 0 Propionate catabolism activator Tmemb_170 PF10190.4 EPA05804.1 - 0.1 12.6 0.8 0.2 11.7 0.1 1.9 2 0 0 2 2 2 0 Putative transmembrane protein 170 V-ATPase_H_N PF03224.9 EPA05804.1 - 0.13 11.3 0.4 0.29 10.2 0.0 1.7 2 0 0 2 2 2 0 V-ATPase subunit H TP_methylase PF00590.15 EPA05806.1 - 7.6e-52 176.0 0.0 8.5e-52 175.9 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases 4HB_MCP_1 PF12729.2 EPA05807.1 - 0.013 14.9 1.4 0.016 14.5 1.0 1.1 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction tRNA_anti-like PF12869.2 EPA05807.1 - 0.045 13.2 0.1 0.045 13.2 0.0 1.1 1 0 0 1 1 1 0 tRNA_anti-like DUF3139 PF11337.3 EPA05807.1 - 0.049 13.9 0.5 0.06 13.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) DUF929 PF06053.6 EPA05807.1 - 0.087 11.8 0.4 0.089 11.8 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF929) GATase_3 PF07685.9 EPA05808.1 - 8.6e-33 113.1 0.3 1.1e-32 112.8 0.2 1.1 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.14 EPA05808.1 - 2.2e-05 24.1 0.0 2.2e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 SNO glutamine amidotransferase family Peptidase_S51 PF03575.12 EPA05808.1 - 0.057 13.1 0.0 0.079 12.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase family S51 DUF1836 PF08876.6 EPA05808.1 - 0.082 12.6 0.4 0.14 11.8 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1836) Endosulfine PF04667.12 EPA05808.1 - 0.21 11.5 3.4 3.8 7.5 0.1 2.5 2 0 0 2 2 2 0 cAMP-regulated phosphoprotein/endosulfine conserved region CbiC PF02570.10 EPA05809.1 - 6.6e-16 58.3 0.1 7.1e-16 58.2 0.1 1.0 1 0 0 1 1 1 1 Precorrin-8X methylmutase CbiX PF01903.12 EPA05810.1 - 1.9e-35 121.1 0.0 4.7e-17 62.0 0.0 2.1 2 0 0 2 2 2 2 CbiX CbiK PF06180.6 EPA05810.1 - 7e-10 38.4 1.5 8.4e-10 38.1 1.0 1.1 1 0 0 1 1 1 1 Cobalt chelatase (CbiK) Ferrochelatase PF00762.14 EPA05810.1 - 1.9e-07 30.4 0.0 0.00031 19.8 0.0 2.0 1 1 1 2 2 2 2 Ferrochelatase Prenyltransf PF01255.14 EPA05810.1 - 0.09 11.8 0.3 0.16 11.0 0.2 1.3 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase CbiG_N PF11760.3 EPA05811.1 - 2.2e-33 113.8 0.2 3.4e-33 113.1 0.1 1.3 1 0 0 1 1 1 1 Cobalamin synthesis G N-terminal CbiG_C PF01890.11 EPA05811.1 - 8.7e-30 103.4 0.2 1.7e-29 102.4 0.1 1.5 1 0 0 1 1 1 1 Cobalamin synthesis G C-terminus CbiG_mid PF11761.3 EPA05811.1 - 1.2e-10 41.4 0.0 3.5e-10 40.0 0.0 1.8 2 0 0 2 2 2 1 Cobalamin biosynthesis central region SpoU_sub_bind PF08032.7 EPA05811.1 - 0.037 14.1 0.1 0.2 11.8 0.0 2.3 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding CbiC PF02570.10 EPA05812.1 - 4e-39 134.1 0.7 4.4e-39 133.9 0.5 1.0 1 0 0 1 1 1 1 Precorrin-8X methylmutase DNA_primase_S PF01896.14 EPA05813.1 - 6.3e-05 22.8 0.0 7.4e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit tRNA_NucTransf2 PF09249.6 EPA05813.1 - 0.087 12.7 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain YycC PF14174.1 EPA05815.1 - 0.043 13.4 0.0 0.097 12.3 0.0 1.6 1 0 0 1 1 1 0 YycC-like protein PAP2 PF01569.16 EPA05818.1 - 3.5e-18 65.5 0.7 4e-18 65.3 0.5 1.0 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.1 EPA05818.1 - 5.5e-06 26.5 0.2 7.3e-06 26.1 0.1 1.1 1 0 0 1 1 1 1 PAP2 superfamily C-terminal PAP2_3 PF14378.1 EPA05818.1 - 7.9e-06 25.5 0.2 9.3e-06 25.2 0.1 1.1 1 0 0 1 1 1 1 PAP2 superfamily PrsW-protease PF13367.1 EPA05818.1 - 0.11 11.6 0.9 0.17 11.0 0.6 1.4 1 1 0 1 1 1 0 Protease prsW family Spc7 PF08317.6 EPA05819.1 - 0.0023 16.6 22.1 0.0023 16.6 15.3 3.0 1 1 2 3 3 3 1 Spc7 kinetochore protein RTBV_P46 PF06216.6 EPA05819.1 - 0.19 10.5 9.2 0.073 11.8 4.8 1.5 1 1 0 1 1 1 0 Rice tungro bacilliform virus P46 protein CENP-Q PF13094.1 EPA05819.1 - 0.72 9.8 40.8 1.3 9.0 16.4 2.2 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Reo_sigmaC PF04582.7 EPA05819.1 - 1.5 7.9 13.5 1 8.4 2.5 2.1 1 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF1664 PF07889.7 EPA05819.1 - 2.2 8.1 29.0 1 9.1 5.0 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) HAUS-augmin3 PF14932.1 EPA05819.1 - 2.6 7.1 40.6 1.4 8.0 6.7 2.4 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DUF4404 PF14357.1 EPA05819.1 - 3.5 8.1 32.1 0.93 9.9 4.1 4.0 1 1 3 4 4 4 0 Domain of unknown function (DUF4404) MCPsignal PF00015.16 EPA05819.1 - 3.8 7.0 26.7 1.5 8.3 10.4 2.1 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Baculo_PEP_C PF04513.7 EPA05819.1 - 4.1 7.2 20.0 1.4 8.7 6.4 3.0 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMF_TATA_bd PF12325.3 EPA05819.1 - 4.7 6.9 36.4 0.29 10.8 12.9 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding KNOX2 PF03791.8 EPA05819.1 - 6.7 6.0 10.0 0.88 8.8 1.8 2.7 2 1 1 3 3 3 0 KNOX2 domain DUF948 PF06103.6 EPA05819.1 - 8.2 6.3 23.8 0.39 10.5 1.3 3.5 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) AAA_13 PF13166.1 EPA05819.1 - 8.5 4.6 43.1 0.41 9.0 22.8 2.2 1 1 1 2 2 2 0 AAA domain CTP_synth_N PF06418.9 EPA05820.1 - 2.3e-122 407.3 0.2 3.2e-122 406.9 0.1 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 EPA05820.1 - 2.3e-50 170.7 0.0 4.1e-50 169.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EPA05820.1 - 1.4e-13 50.8 0.0 1.5e-12 47.4 0.0 2.2 1 1 0 1 1 1 1 Peptidase C26 CbiA PF01656.18 EPA05820.1 - 5e-07 29.3 0.0 1.6e-06 27.7 0.0 1.8 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain zf-C2H2_4 PF13894.1 EPA05822.1 - 0.00047 20.2 13.2 0.063 13.6 1.6 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger Prok-RING_1 PF14446.1 EPA05822.1 - 0.0012 18.5 2.9 0.67 9.7 0.1 2.2 2 0 0 2 2 2 2 Prokaryotic RING finger family 1 zf-RING_3 PF14369.1 EPA05822.1 - 0.0031 17.4 1.9 0.02 14.8 0.1 2.1 2 0 0 2 2 2 1 zinc-finger zf-C2H2 PF00096.21 EPA05822.1 - 0.0081 16.4 13.5 0.22 11.9 2.5 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_2 PF12756.2 EPA05822.1 - 0.012 15.7 4.9 0.012 15.7 3.4 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.1 EPA05822.1 - 0.017 15.4 5.8 0.017 15.4 4.0 2.8 3 0 0 3 3 2 0 Zinc-finger double domain DZR PF12773.2 EPA05822.1 - 0.022 14.5 2.6 0.044 13.5 1.7 1.6 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_5 PF13719.1 EPA05822.1 - 0.032 13.7 5.4 0.57 9.8 3.7 2.1 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA05822.1 - 0.043 13.5 5.2 0.8 9.4 3.6 2.1 1 1 0 1 1 1 0 zinc-ribbon domain zf-C2H2_jaz PF12171.3 EPA05822.1 - 0.045 13.9 15.5 0.28 11.3 2.3 2.7 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF2321 PF10083.4 EPA05822.1 - 0.048 13.1 0.2 0.05 13.1 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) GCC2_GCC3 PF07699.8 EPA05822.1 - 0.056 13.0 0.7 6 6.5 0.0 2.2 2 0 0 2 2 2 0 GCC2 and GCC3 zf-CHCC PF10276.4 EPA05822.1 - 0.073 12.9 0.8 1.2 9.0 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger domain zf-C2H2_6 PF13912.1 EPA05822.1 - 0.092 12.6 6.0 2.6 8.0 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger DNA_RNApol_7kD PF03604.8 EPA05822.1 - 0.11 12.0 2.4 0.63 9.5 0.2 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit LIM PF00412.17 EPA05822.1 - 0.11 12.5 7.9 0.13 12.3 5.2 1.4 1 1 0 1 1 1 0 LIM domain YhfH PF14149.1 EPA05822.1 - 0.13 12.0 0.3 0.13 12.0 0.2 2.0 2 0 0 2 2 2 0 YhfH-like protein Mut7-C PF01927.11 EPA05822.1 - 0.13 12.2 2.9 0.15 12.0 1.9 1.3 1 1 0 1 1 1 0 Mut7-C RNAse domain Ribosomal_S27e PF01667.12 EPA05822.1 - 0.13 11.7 3.7 0.33 10.5 2.6 1.7 1 1 0 1 1 1 0 Ribosomal protein S27 zf-CSL PF05207.8 EPA05822.1 - 0.17 11.3 2.2 0.33 10.4 1.5 1.5 1 1 0 1 1 1 0 CSL zinc finger zf-trcl PF13451.1 EPA05822.1 - 0.26 10.9 3.1 0.76 9.4 0.2 2.2 2 0 0 2 2 2 0 Probable zinc-binding domain zf-FCS PF06467.9 EPA05822.1 - 0.39 10.4 5.2 2.5 7.8 0.7 2.2 1 1 1 2 2 2 0 MYM-type Zinc finger with FCS sequence motif DUF629 PF04780.7 EPA05822.1 - 0.42 9.0 14.9 0.87 8.0 6.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) Ribosomal_L37e PF01907.14 EPA05822.1 - 0.44 10.3 5.1 4.3 7.2 0.9 2.3 2 0 0 2 2 2 0 Ribosomal protein L37e zinc_ribbon_2 PF13240.1 EPA05822.1 - 0.99 8.9 5.0 2.6 7.6 1.6 2.1 1 1 0 2 2 2 0 zinc-ribbon domain zf-BED PF02892.10 EPA05822.1 - 1 9.1 9.9 0.42 10.4 3.7 2.2 1 1 1 2 2 2 0 BED zinc finger Terminase_GpA PF05876.7 EPA05822.1 - 1 7.6 5.8 1.1 7.5 4.0 1.0 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) FYVE PF01363.16 EPA05822.1 - 1.6 8.6 10.8 2 8.3 2.9 2.1 1 1 1 2 2 2 0 FYVE zinc finger zf-LYAR PF08790.6 EPA05822.1 - 1.8 8.3 7.3 0.42 10.3 0.9 2.4 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-HYPF PF07503.7 EPA05822.1 - 2.9 7.3 6.8 0.38 10.2 0.8 2.1 2 1 0 2 2 2 0 HypF finger zf-Di19 PF05605.7 EPA05822.1 - 4.5 7.4 17.7 4.8 7.3 3.7 2.1 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding YdjO PF14169.1 EPA05825.1 - 0.018 14.4 0.2 0.023 14.1 0.1 1.2 1 0 0 1 1 1 0 Cold-inducible protein YdjO Herpes_UL31 PF02718.9 EPA05825.1 - 0.024 13.3 0.2 0.024 13.3 0.2 1.0 1 0 0 1 1 1 0 Herpesvirus UL31-like protein zf-RING_4 PF14570.1 EPA05825.1 - 0.055 13.0 0.2 0.092 12.3 0.0 1.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-ISL3 PF14690.1 EPA05825.1 - 0.064 13.2 1.1 0.08 12.9 0.7 1.2 1 0 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Spt4 PF06093.8 EPA05825.1 - 0.075 12.9 0.4 0.075 12.9 0.3 1.1 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger zinc_ribbon_2 PF13240.1 EPA05825.1 - 0.076 12.5 2.1 0.11 12.0 1.4 1.4 1 0 0 1 1 1 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 EPA05825.1 - 0.084 12.5 0.7 0.1 12.2 0.5 1.1 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.1 EPA05825.1 - 0.1 11.8 0.3 0.15 11.2 0.2 1.3 1 0 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 EPA05825.1 - 0.13 12.2 1.6 0.14 12.1 0.4 1.5 1 1 1 2 2 2 0 Zinc ribbon domain Chorismate_bind PF00425.13 EPA05826.1 - 2.9e-90 302.0 0.0 1.4e-89 299.7 0.0 2.0 2 1 1 3 3 3 1 chorismate binding enzyme Anth_synt_I_N PF04715.8 EPA05826.1 - 2.8e-22 79.2 0.4 1.1e-20 74.0 0.0 2.8 2 1 0 2 2 2 1 Anthranilate synthase component I, N terminal region NAD_kinase PF01513.16 EPA05828.1 - 1.1e-32 113.0 0.5 1.4e-32 112.6 0.3 1.1 1 0 0 1 1 1 1 ATP-NAD kinase TrmB PF01978.14 EPA05828.1 - 3.7e-05 23.3 0.8 0.0022 17.6 0.1 2.8 2 1 0 3 3 3 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 EPA05828.1 - 0.00033 19.9 2.4 0.00072 18.8 0.1 2.5 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding MarR PF01047.17 EPA05828.1 - 0.0012 18.5 1.0 0.0039 16.8 0.0 2.3 3 0 0 3 3 3 1 MarR family MarR_2 PF12802.2 EPA05828.1 - 0.0036 16.9 0.0 0.017 14.8 0.0 2.1 2 0 0 2 2 2 1 MarR family RNA_pol_Rpc34 PF05158.7 EPA05828.1 - 0.0038 16.4 0.2 0.0059 15.8 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit HTH_27 PF13463.1 EPA05828.1 - 0.029 14.6 0.2 0.071 13.4 0.1 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain FeoC PF09012.5 EPA05828.1 - 0.068 12.8 1.2 0.26 11.0 0.0 2.4 3 0 0 3 3 3 0 FeoC like transcriptional regulator Hint PF01079.15 EPA05830.1 - 0.035 13.3 0.0 0.042 13.0 0.0 1.2 1 0 0 1 1 1 0 Hint module Trp_syntA PF00290.15 EPA05831.1 - 3.1e-85 284.8 2.4 3.4e-85 284.6 1.7 1.0 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PcrB PF01884.12 EPA05831.1 - 4.2e-08 32.7 0.5 6.2e-07 28.8 0.2 2.3 2 0 0 2 2 2 1 PcrB family His_biosynth PF00977.16 EPA05831.1 - 5e-08 32.5 0.3 2.1e-07 30.4 0.1 1.9 2 0 0 2 2 2 1 Histidine biosynthesis protein DHO_dh PF01180.16 EPA05831.1 - 3.2e-07 29.6 1.0 4.3e-07 29.1 0.7 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase IMPDH PF00478.20 EPA05831.1 - 1.5e-05 24.0 0.4 0.00019 20.4 0.1 2.2 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 EPA05831.1 - 1.8e-05 23.7 0.0 8.2e-05 21.6 0.0 2.0 1 1 2 3 3 3 1 FMN-dependent dehydrogenase NanE PF04131.9 EPA05831.1 - 3.4e-05 22.9 0.5 0.00048 19.1 0.1 2.7 3 0 0 3 3 3 1 Putative N-acetylmannosamine-6-phosphate epimerase ThiG PF05690.9 EPA05831.1 - 0.00065 18.8 0.2 0.0014 17.7 0.0 1.7 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG IGPS PF00218.16 EPA05831.1 - 0.0015 17.6 0.0 0.01 14.9 0.0 2.0 1 1 1 2 2 2 1 Indole-3-glycerol phosphate synthase BtpA PF03437.10 EPA05831.1 - 0.0033 16.7 1.8 0.023 13.9 1.3 2.4 1 1 0 1 1 1 1 BtpA family Dus PF01207.12 EPA05831.1 - 0.0087 14.9 0.0 0.027 13.3 0.0 1.7 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) TMP-TENI PF02581.12 EPA05831.1 - 0.0091 15.1 0.9 0.025 13.6 0.6 2.0 1 1 0 1 1 1 1 Thiamine monophosphate synthase/TENI NMO PF03060.10 EPA05831.1 - 0.026 13.6 0.0 0.059 12.5 0.0 1.6 2 0 0 2 2 2 0 Nitronate monooxygenase Ribul_P_3_epim PF00834.14 EPA05831.1 - 0.029 13.4 0.2 0.046 12.8 0.2 1.5 1 1 0 1 1 1 0 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.14 EPA05831.1 - 0.031 13.8 0.1 3.9 6.9 0.0 2.5 2 1 1 3 3 3 0 Quinolinate phosphoribosyl transferase, C-terminal domain TGT PF01702.13 EPA05831.1 - 0.036 13.3 0.0 0.098 11.9 0.0 1.7 1 1 0 1 1 1 0 Queuine tRNA-ribosyltransferase GDPD PF03009.12 EPA05831.1 - 0.049 13.1 0.0 0.19 11.1 0.0 1.9 2 1 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family PALP PF00291.20 EPA05832.1 - 8.5e-43 146.7 1.2 1e-42 146.4 0.8 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PAC2 PF09754.4 EPA05833.1 - 5.9e-22 78.6 0.0 6.6e-22 78.4 0.0 1.0 1 0 0 1 1 1 1 PAC2 family PDDEXK_1 PF12705.2 EPA05834.1 - 3.4e-08 33.1 0.1 1.9e-07 30.7 0.1 1.9 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Cas_Cas4 PF01930.12 EPA05834.1 - 0.051 13.4 0.0 0.081 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF83 DUF2800 PF10926.3 EPA05834.1 - 0.058 12.5 0.1 5.9 5.8 0.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF2800) PMT_2 PF13231.1 EPA05836.1 - 8.1e-10 38.8 18.6 8.1e-10 38.8 12.9 2.8 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PARP_regulatory PF01358.13 EPA05837.1 - 0.0043 15.7 0.1 0.0096 14.5 0.0 1.4 1 1 0 1 1 1 1 Poly A polymerase regulatory subunit RecR PF02132.10 EPA05838.1 - 0.067 12.6 0.0 0.085 12.3 0.0 1.2 1 0 0 1 1 1 0 RecR protein GATase PF00117.23 EPA05839.1 - 7.7e-56 188.5 0.0 8.5e-56 188.4 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EPA05839.1 - 1.5e-09 37.5 0.2 3.5e-09 36.4 0.1 1.5 1 1 0 1 1 1 1 Peptidase C26 SNO PF01174.14 EPA05839.1 - 4.4e-05 23.1 0.1 0.00016 21.3 0.0 1.8 2 0 0 2 2 2 1 SNO glutamine amidotransferase family zf-met2 PF12907.2 EPA05841.1 - 0.016 15.1 1.0 0.024 14.6 0.7 1.6 1 1 0 1 1 1 0 Zinc-binding zf-C2H2_4 PF13894.1 EPA05841.1 - 0.041 14.2 0.6 0.076 13.3 0.4 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger Transpep_BrtH PF14399.1 EPA05841.1 - 0.081 12.2 0.0 0.081 12.2 0.0 1.0 1 0 0 1 1 1 0 NlpC/p60-like transpeptidase TF_Zn_Ribbon PF08271.7 EPA05842.1 - 0.02 14.2 4.1 0.24 10.7 2.9 2.2 1 1 0 1 1 1 0 TFIIB zinc-binding zf-H2C2_2 PF13465.1 EPA05842.1 - 0.028 14.7 2.1 2.6 8.4 0.7 2.3 2 0 0 2 2 2 0 Zinc-finger double domain zinc_ribbon_4 PF13717.1 EPA05842.1 - 0.044 13.4 1.4 3.6 7.3 0.0 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 EPA05842.1 - 0.048 13.2 1.9 2.4 7.8 0.0 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-LITAF-like PF10601.4 EPA05842.1 - 0.054 13.3 0.9 1.4 8.8 0.1 2.1 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain RIG-I_C-RD PF11648.3 EPA05842.1 - 0.061 13.1 0.4 7 6.5 0.0 2.1 2 0 0 2 2 2 0 C-terminal domain of RIG-I PHD PF00628.24 EPA05842.1 - 0.062 13.0 0.7 6.5 6.5 0.0 2.2 2 0 0 2 2 2 0 PHD-finger A2L_zn_ribbon PF08792.5 EPA05842.1 - 0.12 11.8 3.3 0.63 9.5 0.1 2.3 2 0 0 2 2 2 0 A2L zinc ribbon domain Rpr2 PF04032.11 EPA05842.1 - 0.28 11.0 2.7 0.6 10.0 1.9 1.5 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Glycos_transf_2 PF00535.21 EPA05843.1 - 2e-32 112.1 0.1 8.9e-32 110.0 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 2 GtrA PF04138.9 EPA05843.1 - 9e-24 83.6 11.6 3.4e-22 78.5 8.7 2.3 1 1 0 1 1 1 1 GtrA-like protein Glyco_tranf_2_3 PF13641.1 EPA05843.1 - 7.4e-10 39.0 0.0 1.2e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 EPA05843.1 - 0.00029 19.9 0.4 0.00058 19.0 0.1 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EPA05843.1 - 0.0012 18.2 0.0 0.0021 17.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 NTP_transf_3 PF12804.2 EPA05843.1 - 0.0099 15.9 0.0 0.015 15.4 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Glyco_tranf_2_5 PF13712.1 EPA05843.1 - 0.087 12.0 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family P12 PF12669.2 EPA05846.1 - 0.022 14.9 3.6 0.029 14.5 2.5 1.2 1 0 0 1 1 1 0 Virus attachment protein p12 family RecR PF02132.10 EPA05846.1 - 0.032 13.6 2.7 0.039 13.3 1.9 1.2 1 0 0 1 1 1 0 RecR protein DZR PF12773.2 EPA05846.1 - 0.046 13.5 2.1 0.06 13.1 1.5 1.1 1 0 0 1 1 1 0 Double zinc ribbon zf-UBR PF02207.15 EPA05846.1 - 0.068 12.8 2.3 0.083 12.6 1.6 1.1 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) zf-CXXC PF02008.15 EPA05846.1 - 0.11 12.3 2.1 0.13 12.0 1.5 1.1 1 0 0 1 1 1 0 CXXC zinc finger domain NB PF04159.8 EPA05846.1 - 0.49 10.1 5.0 0.59 9.9 3.5 1.0 1 0 0 1 1 1 0 NB glycoprotein GCC2_GCC3 PF07699.8 EPA05846.1 - 0.92 9.1 6.3 0.75 9.4 0.9 2.0 1 1 1 2 2 2 0 GCC2 and GCC3 zf-FCS PF06467.9 EPA05846.1 - 1.4 8.6 7.2 1 9.0 0.4 2.1 1 1 1 2 2 2 0 MYM-type Zinc finger with FCS sequence motif YyzF PF14116.1 EPA05846.1 - 1.5 8.8 3.8 20 5.2 2.6 2.0 1 1 0 1 1 1 0 YyzF-like protein DUF4292 PF14125.1 EPA05847.1 - 0.0059 16.0 0.2 0.0064 15.9 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4292) TA0956 PF11513.3 EPA05847.1 - 0.048 13.7 0.9 0.057 13.4 0.6 1.1 1 0 0 1 1 1 0 Thermoplasma acidophilum protein TA0956 KAR9 PF08580.5 EPA05847.1 - 0.097 10.9 0.6 0.091 11.0 0.4 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 PfkB PF00294.19 EPA05848.1 - 3.6e-12 46.0 0.1 3.1e-11 42.9 0.1 1.9 1 1 0 1 1 1 1 pfkB family carbohydrate kinase NTNH_C PF08470.5 EPA05848.1 - 0.026 14.1 0.1 0.043 13.4 0.1 1.3 1 0 0 1 1 1 0 Nontoxic nonhaemagglutinin C-terminal HMA PF00403.21 EPA05848.1 - 0.042 13.9 0.2 0.11 12.6 0.1 1.7 1 0 0 1 1 1 0 Heavy-metal-associated domain Glycos_transf_3 PF00591.16 EPA05849.1 - 4.8e-79 265.3 1.3 7e-79 264.8 0.9 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.12 EPA05849.1 - 6.7e-12 44.8 0.1 1.4e-11 43.8 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Nitroreductase PF00881.19 EPA05850.1 - 3.7e-30 104.9 0.0 5.2e-30 104.4 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family DUF1157 PF06636.6 EPA05850.1 - 0.054 12.0 0.0 0.082 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1157) Aldo_ket_red PF00248.16 EPA05852.1 - 1.4e-53 181.5 0.0 1.6e-53 181.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family IGPS PF00218.16 EPA05853.1 - 1.9e-71 240.1 0.5 2.2e-71 239.8 0.3 1.0 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase QRPTase_C PF01729.14 EPA05853.1 - 4.7e-06 26.2 0.0 1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain NanE PF04131.9 EPA05853.1 - 0.00027 19.9 0.1 0.0007 18.6 0.1 1.8 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase FMN_dh PF01070.13 EPA05853.1 - 0.00035 19.5 0.0 0.0015 17.4 0.0 1.8 1 1 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 EPA05853.1 - 0.0021 17.3 0.0 0.0069 15.6 0.0 1.9 2 0 0 2 2 2 1 Histidine biosynthesis protein DUF556 PF04476.8 EPA05853.1 - 0.0035 16.5 0.0 0.01 15.1 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF556) DHO_dh PF01180.16 EPA05853.1 - 0.0038 16.2 0.5 0.16 10.8 0.0 2.4 2 1 1 3 3 3 1 Dihydroorotate dehydrogenase PcrB PF01884.12 EPA05853.1 - 0.0042 16.3 0.0 0.0076 15.5 0.0 1.4 1 0 0 1 1 1 1 PcrB family Cellulase PF00150.13 EPA05853.1 - 0.013 14.6 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) AP_endonuc_2 PF01261.19 EPA05853.1 - 0.021 14.1 0.0 0.037 13.3 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Glyco_hydro_97 PF10566.4 EPA05853.1 - 0.035 13.2 0.0 0.055 12.5 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase 97 EAL PF00563.15 EPA05853.1 - 0.064 12.7 0.1 9.1 5.6 0.0 2.5 2 1 0 3 3 3 0 EAL domain ThiG PF05690.9 EPA05853.1 - 0.07 12.1 0.0 0.16 10.9 0.0 1.6 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG Rad50_zn_hook PF04423.9 EPA05854.1 - 0.14 11.6 0.7 0.19 11.2 0.5 1.3 1 0 0 1 1 1 0 Rad50 zinc hook motif Kazal_1 PF00050.16 EPA05855.1 - 9e-11 41.6 0.4 1.6e-10 40.8 0.3 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.10 EPA05855.1 - 2.8e-10 39.9 1.2 4.5e-10 39.2 0.9 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain HEAT_2 PF13646.1 EPA05856.1 - 3e-05 24.2 0.0 3.1e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 HEAT repeats HEAT PF02985.17 EPA05856.1 - 0.0048 16.8 0.0 0.0077 16.2 0.0 1.3 1 0 0 1 1 1 1 HEAT repeat HEAT_EZ PF13513.1 EPA05856.1 - 0.008 16.6 0.0 0.01 16.3 0.0 1.2 1 0 0 1 1 1 1 HEAT-like repeat CBS PF00571.23 EPA05857.1 - 1.9e-45 152.3 2.3 5.4e-11 42.1 0.0 4.2 4 0 0 4 4 4 4 CBS domain DUF2497 PF10691.4 EPA05857.1 - 0.069 13.1 0.0 0.27 11.2 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2497) PduV-EutP PF10662.4 EPA05857.1 - 0.74 9.2 7.2 2.4 7.6 0.1 3.8 3 1 1 4 4 4 0 Ethanolamine utilisation - propanediol utilisation EamA PF00892.15 EPA05858.1 - 1.5e-16 60.6 11.2 1.7e-16 60.3 7.7 1.0 1 0 0 1 1 1 1 EamA-like transporter family EmrE PF13536.1 EPA05858.1 - 3.7e-06 27.0 9.0 5.2e-06 26.6 6.2 1.2 1 0 0 1 1 1 1 Multidrug resistance efflux transporter DUF1097 PF06496.6 EPA05858.1 - 0.32 10.7 9.3 0.45 10.3 6.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1097) TPT PF03151.11 EPA05858.1 - 1.1 8.9 9.4 2 8.0 6.5 1.6 1 1 0 1 1 1 0 Triose-phosphate Transporter family Multi_Drug_Res PF00893.14 EPA05858.1 - 1.8 9.0 7.6 6.2 7.3 5.3 2.0 1 1 0 1 1 1 0 Small Multidrug Resistance protein DUF1212 PF06738.7 EPA05858.1 - 5.2 6.4 10.1 27 4.1 6.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1212) Zip PF02535.17 EPA05858.1 - 8.2 5.3 9.5 13 4.6 4.1 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter PAPS_reduct PF01507.14 EPA05860.1 - 0.062 13.1 0.1 0.062 13.1 0.1 1.0 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family AAA_8 PF12780.2 EPA05860.1 - 0.064 12.2 0.1 0.068 12.1 0.1 1.0 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 HTH_24 PF13412.1 EPA05861.1 - 1.1e-05 24.7 1.9 2.3e-05 23.6 1.3 1.6 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 EPA05861.1 - 0.00014 21.3 3.7 0.00047 19.6 2.6 1.9 1 1 0 1 1 1 1 AsnC-type helix-turn-helix domain B5 PF03484.10 EPA05865.1 - 1.6e-20 72.7 0.2 2.1e-14 53.0 0.0 3.0 3 0 0 3 3 3 2 tRNA synthetase B5 domain B3_4 PF03483.12 EPA05865.1 - 2.1e-12 46.8 0.3 3.7e-12 46.0 0.2 1.3 1 0 0 1 1 1 1 B3/4 domain RNA_bind_2 PF10133.4 EPA05866.1 - 0.027 14.4 1.6 0.047 13.7 0.2 1.9 2 0 0 2 2 2 0 Predicted RNA-binding protein EVE PF01878.13 EPA05867.1 - 7.7e-39 132.9 0.5 8.7e-39 132.7 0.3 1.0 1 0 0 1 1 1 1 EVE domain DUF1175 PF06672.6 EPA05867.1 - 0.03 13.6 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1175) CRF1 PF10380.4 EPA05867.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Transcription factor CRF1 Phytoreo_S7 PF07236.6 EPA05867.1 - 0.15 10.3 0.4 0.25 9.6 0.3 1.3 1 1 0 1 1 1 0 Phytoreovirus S7 protein SOR_SNZ PF01680.12 EPA05868.1 - 1.1e-91 306.0 3.0 1.5e-91 305.6 2.1 1.1 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.9 EPA05868.1 - 2.3e-07 30.1 1.6 8.5e-06 25.0 0.1 2.2 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 EPA05868.1 - 5.4e-05 22.5 0.5 0.014 14.6 0.0 3.1 2 1 0 2 2 2 1 Histidine biosynthesis protein IGPS PF00218.16 EPA05868.1 - 0.00066 18.8 0.0 0.0061 15.6 0.0 2.2 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase Dus PF01207.12 EPA05868.1 - 0.00074 18.4 0.2 0.76 8.5 0.1 2.2 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) NMO PF03060.10 EPA05868.1 - 0.0035 16.5 5.8 0.055 12.6 0.2 2.4 2 1 0 2 2 2 2 Nitronate monooxygenase OMPdecase PF00215.19 EPA05868.1 - 0.0063 15.9 0.5 0.77 9.1 0.0 2.5 2 1 0 2 2 2 1 Orotidine 5'-phosphate decarboxylase / HUMPS family NanE PF04131.9 EPA05868.1 - 0.015 14.2 3.0 0.58 9.0 0.0 3.3 2 2 1 3 3 3 0 Putative N-acetylmannosamine-6-phosphate epimerase PcrB PF01884.12 EPA05868.1 - 0.016 14.4 0.1 0.037 13.2 0.1 1.6 1 0 0 1 1 1 0 PcrB family tRNA-synt_2d PF01409.15 EPA05870.1 - 3.3e-84 281.9 0.0 5.1e-84 281.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.15 EPA05870.1 - 1e-05 24.5 0.2 0.00077 18.3 0.0 2.9 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.20 EPA05870.1 - 0.00054 19.5 0.2 0.0011 18.5 0.1 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Mer2 PF09074.5 EPA05870.1 - 0.015 15.1 1.5 0.029 14.3 1.1 1.4 1 0 0 1 1 1 0 Mer2 HTH_24 PF13412.1 EPA05870.1 - 0.041 13.2 2.6 0.18 11.2 0.1 2.8 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.16 EPA05871.1 - 2e-11 43.4 0.0 2.3e-11 43.2 0.0 1.0 1 0 0 1 1 1 1 AsnC family Aconitase PF00330.15 EPA05872.1 - 5.3e-152 506.5 0.1 5.9e-151 503.0 0.1 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EPA05872.1 - 2.3e-36 124.8 0.1 5.8e-36 123.4 0.0 1.8 2 0 0 2 2 2 1 Aconitase C-terminal domain DUF521 PF04412.8 EPA05872.1 - 0.014 13.9 0.0 0.023 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) tRNA-synt_1b PF00579.20 EPA05873.1 - 1.4e-29 103.1 0.0 2.1e-29 102.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1f PF01921.13 EPA05873.1 - 0.025 13.2 0.1 0.27 9.8 0.0 2.1 1 1 0 2 2 2 0 tRNA synthetases class I (K) EFP PF01132.15 EPA05874.1 - 0.048 13.3 0.4 0.084 12.5 0.2 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) OB domain SNO PF01174.14 EPA05875.1 - 5.9e-50 169.5 0.1 6.7e-50 169.3 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 EPA05875.1 - 7.4e-13 48.3 0.0 1.2e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.23 EPA05875.1 - 1e-12 47.8 0.0 1.3e-11 44.3 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EPA05875.1 - 8.6e-08 31.8 0.0 8e-07 28.7 0.0 2.3 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.19 EPA05875.1 - 4.6e-07 29.3 0.0 6.2e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family Peptidase_S51 PF03575.12 EPA05875.1 - 2.6e-06 27.2 0.0 3.4e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 DUF4066 PF13278.1 EPA05875.1 - 0.078 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative amidotransferase DUF2315 PF10231.4 EPA05876.1 - 0.0084 15.9 0.4 0.0095 15.8 0.3 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2315) Baculo_PEP_C PF04513.7 EPA05877.1 - 0.011 15.5 1.5 0.026 14.3 1.0 1.6 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.7 EPA05877.1 - 0.022 13.9 2.7 0.036 13.2 1.9 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Atg14 PF10186.4 EPA05877.1 - 0.042 12.7 0.0 0.069 12.0 0.0 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Filamin PF00630.14 EPA05877.1 - 0.096 13.2 0.0 0.34 11.5 0.0 1.9 2 1 0 2 2 2 0 Filamin/ABP280 repeat NPV_P10 PF05531.7 EPA05877.1 - 0.29 11.4 2.2 20 5.4 0.1 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Hydrolase PF00702.21 EPA05879.1 - 1.3e-10 42.0 0.3 2.1e-10 41.3 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EPA05879.1 - 0.00048 19.7 0.3 0.00059 19.4 0.2 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EPA05879.1 - 0.00096 19.3 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Usp PF00582.21 EPA05880.1 - 5.8e-30 104.3 0.0 6.5e-30 104.1 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family AA_permease_2 PF13520.1 EPA05881.1 - 1.5e-56 191.7 55.9 1.7e-56 191.5 38.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EPA05881.1 - 8.8e-39 133.1 48.5 1.1e-38 132.8 33.6 1.0 1 0 0 1 1 1 1 Amino acid permease Spore_permease PF03845.8 EPA05881.1 - 0.014 14.0 39.3 0.0025 16.5 17.9 2.5 2 1 0 2 2 2 0 Spore germination protein AA_permease_C PF13906.1 EPA05881.1 - 0.032 14.0 1.7 0.032 14.0 1.1 4.6 6 0 0 6 6 6 0 C-terminus of AA_permease MOFRL PF05161.8 EPA05882.1 - 0.00016 21.7 0.0 0.00016 21.7 0.0 1.0 1 0 0 1 1 1 1 MOFRL family AAA_13 PF13166.1 EPA05883.1 - 0.026 13.0 3.9 0.028 12.9 2.7 1.1 1 0 0 1 1 1 0 AAA domain NPV_P10 PF05531.7 EPA05883.1 - 0.16 12.2 2.1 2.3 8.4 0.1 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DASH_Dam1 PF08653.5 EPA05883.1 - 4.1 7.2 7.3 3.3 7.5 0.8 3.0 2 1 2 4 4 4 0 DASH complex subunit Dam1 CbiC PF02570.10 EPA05885.1 - 3.2e-35 121.3 0.4 3.5e-35 121.2 0.3 1.0 1 0 0 1 1 1 1 Precorrin-8X methylmutase CbiC PF02570.10 EPA05886.1 - 5.3e-13 48.8 0.4 5.7e-13 48.7 0.3 1.0 1 0 0 1 1 1 1 Precorrin-8X methylmutase CbiX PF01903.12 EPA05887.1 - 1.5e-16 60.3 0.0 2e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 CbiX CbiK PF06180.6 EPA05887.1 - 1.3e-06 27.7 0.2 1.5e-06 27.5 0.1 1.0 1 0 0 1 1 1 1 Cobalt chelatase (CbiK) Prenyltransf PF01255.14 EPA05887.1 - 0.068 12.2 0.3 0.091 11.8 0.2 1.1 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase Ferrochelatase PF00762.14 EPA05887.1 - 0.085 11.8 0.1 0.2 10.5 0.0 1.6 2 0 0 2 2 2 0 Ferrochelatase GATase_3 PF07685.9 EPA05888.1 - 1.7e-20 73.2 0.1 1.8e-20 73.1 0.1 1.0 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DUF1836 PF08876.6 EPA05888.1 - 0.026 14.2 0.2 0.036 13.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1836) DUF2681 PF10883.3 EPA05889.1 - 0.98 9.6 4.1 1.1 9.5 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) tRNA_anti-codon PF01336.20 EPA05891.1 - 5.7e-06 26.0 0.0 0.15 11.9 0.0 2.4 2 0 0 2 2 2 2 OB-fold nucleic acid binding domain RNA_pol_Rpb1_1 PF04997.7 EPA05891.1 - 0.068 12.4 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 DUF354 PF04007.7 EPA05892.1 - 2.7e-51 174.4 4.2 3.2e-51 174.1 2.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF354) LpxB PF02684.10 EPA05892.1 - 0.00042 19.0 0.0 0.00059 18.5 0.0 1.2 1 0 0 1 1 1 1 Lipid-A-disaccharide synthetase AAA_12 PF13087.1 EPA05892.1 - 0.08 12.2 0.7 0.12 11.7 0.5 1.2 1 0 0 1 1 1 0 AAA domain KH_5 PF13184.1 EPA05892.1 - 0.091 12.5 1.5 9.1 6.1 0.1 3.0 1 1 1 2 2 2 0 NusA-like KH domain Glyco_trans_1_3 PF13528.1 EPA05892.1 - 0.12 11.5 0.0 0.19 10.8 0.0 1.4 1 1 0 1 1 1 0 Glycosyl transferase family 1 ABC_tran PF00005.22 EPA05893.1 - 4.6e-29 101.4 0.0 8.1e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EPA05893.1 - 9e-13 48.8 4.1 4.3e-11 43.3 0.6 2.9 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.1 EPA05893.1 - 1.6e-06 27.4 7.1 7.8e-06 25.1 0.0 2.9 2 1 0 3 3 3 1 AAA ATPase domain DUF4162 PF13732.1 EPA05893.1 - 0.00082 19.8 1.2 0.002 18.5 0.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_29 PF13555.1 EPA05893.1 - 0.0012 18.3 0.4 0.0022 17.4 0.3 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 EPA05893.1 - 0.0097 16.2 7.2 0.058 13.7 5.0 2.2 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.1 EPA05893.1 - 0.012 15.4 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Mg_chelatase PF01078.16 EPA05893.1 - 0.032 13.3 0.0 0.051 12.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 EPA05893.1 - 0.064 13.2 0.0 0.1 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain SMC_N PF02463.14 EPA05893.1 - 0.082 12.1 0.9 11 5.1 0.0 2.5 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.18 EPA05893.1 - 0.083 12.8 2.7 2.7 7.9 0.3 2.4 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_17 PF13207.1 EPA05893.1 - 0.41 11.4 2.9 1 10.1 0.4 2.4 1 1 1 2 2 2 0 AAA domain DUF87 PF01935.12 EPA05893.1 - 1.1 9.0 5.9 6.4 6.5 0.2 2.5 2 1 0 2 2 2 0 Domain of unknown function DUF87 tRNA_anti-codon PF01336.20 EPA05894.1 - 4e-05 23.3 0.3 0.00044 20.0 0.0 2.5 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain UDPG_MGDP_dh_N PF03721.9 EPA05895.1 - 1.8e-07 30.7 0.4 0.0011 18.4 0.0 2.3 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.13 EPA05895.1 - 6.2e-06 26.2 0.0 1.5e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.10 EPA05895.1 - 0.015 15.1 0.0 0.12 12.1 0.0 2.3 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase OKR_DC_1 PF01276.15 EPA05895.1 - 0.016 13.7 0.0 0.022 13.3 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain dTMP_synthase PF02593.9 EPA05895.1 - 0.021 14.1 0.0 0.033 13.5 0.0 1.4 1 0 0 1 1 1 0 Thymidylate synthase DEAD PF00270.24 EPA05896.1 - 5.6e-29 100.8 0.4 9.9e-29 99.9 0.1 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 EPA05896.1 - 5.5e-09 36.1 0.0 8.4e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 EPA05896.1 - 7.3e-07 28.2 0.0 9.6e-07 27.8 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain ABC2_membrane PF01061.19 EPA05898.1 - 1.5e-20 73.2 21.2 1.5e-20 73.2 14.7 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 EPA05898.1 - 2.6e-15 56.3 35.7 5.3e-15 55.3 17.6 2.0 1 1 1 2 2 2 2 ABC-2 family transporter protein ABC2_membrane_4 PF12730.2 EPA05898.1 - 3.5e-10 39.4 30.0 4.7e-10 39.0 20.8 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_5 PF13346.1 EPA05898.1 - 0.098 11.9 31.1 0.61 9.3 21.5 2.1 1 1 0 1 1 1 0 ABC-2 family transporter protein DEAD_assoc PF08494.6 EPA05899.1 - 1.8e-34 119.1 0.0 4.7e-34 117.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/H associated Helicase_C PF00271.26 EPA05899.1 - 1.2e-05 25.1 0.1 2.9e-05 23.8 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HypA PF01155.14 EPA05899.1 - 0.15 11.8 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Secretin_N_2 PF07655.8 EPA05899.1 - 0.22 11.9 3.0 0.41 11.0 2.1 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Ribosomal_L39 PF00832.15 EPA05900.1 - 1.5e-17 62.7 7.6 1.7e-17 62.5 5.3 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein REV PF00424.13 EPA05900.1 - 0.38 10.6 3.9 0.4 10.6 2.7 1.1 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) NUDIX PF00293.23 EPA05901.1 - 5.2e-13 48.8 0.0 6.2e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain Ribosomal_L31e PF01198.14 EPA05902.1 - 2.4e-24 84.7 0.3 3.7e-24 84.2 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e Rhodanese PF00581.15 EPA05903.1 - 1.9e-33 115.1 0.0 7e-19 68.2 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain TPR_11 PF13414.1 EPA05904.1 - 1.1e-22 79.4 1.7 9.8e-11 41.1 0.0 3.2 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 EPA05904.1 - 3.2e-21 73.4 3.6 5.3e-07 29.0 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.23 EPA05904.1 - 8.4e-20 69.4 5.1 5.6e-07 28.9 0.1 4.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 EPA05904.1 - 1.1e-16 61.0 0.1 1.6e-07 31.7 0.0 3.2 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 EPA05904.1 - 1.4e-14 53.7 3.1 2.2e-05 24.2 0.2 3.5 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 EPA05904.1 - 2.3e-14 52.3 0.4 0.0013 18.7 0.0 3.9 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 EPA05904.1 - 1.8e-13 50.6 3.1 3.8e-08 33.5 0.1 2.7 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 EPA05904.1 - 4.5e-11 42.3 0.4 0.014 15.9 0.0 4.8 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 EPA05904.1 - 7.3e-10 37.9 5.2 0.00046 19.7 0.0 4.9 5 0 0 5 5 4 2 Tetratricopeptide repeat Apc3 PF12895.2 EPA05904.1 - 9.7e-08 32.0 0.3 3.4e-07 30.3 0.1 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.1 EPA05904.1 - 7.7e-07 28.8 0.2 0.063 13.1 0.0 3.8 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.1 EPA05904.1 - 1.2e-06 28.2 0.0 0.00027 20.7 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.1 EPA05904.1 - 1.2e-05 25.0 1.2 0.8 9.7 0.0 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 EPA05904.1 - 2.6e-05 24.3 3.3 1.4 9.5 0.0 4.9 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.1 EPA05904.1 - 0.00013 21.5 1.9 5.8 6.9 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat Coatomer_E PF04733.9 EPA05904.1 - 0.0023 17.1 1.1 0.04 13.1 0.1 2.5 1 1 2 3 3 3 1 Coatomer epsilon subunit NARP1 PF12569.3 EPA05904.1 - 0.0043 15.8 3.0 0.37 9.4 0.0 2.5 1 1 0 2 2 2 2 NMDA receptor-regulated protein 1 HTH_27 PF13463.1 EPA05904.1 - 0.0049 17.1 0.2 0.014 15.6 0.1 1.8 1 0 0 1 1 1 1 Winged helix DNA-binding domain TPR_20 PF14561.1 EPA05904.1 - 0.0056 16.7 0.7 0.87 9.7 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.7 EPA05904.1 - 0.0094 15.7 2.0 7.3 6.5 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TrmB PF01978.14 EPA05904.1 - 0.032 13.9 0.0 5.2 6.8 0.0 3.0 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB NIR_SIR PF01077.17 EPA05906.1 - 2.2e-41 140.8 0.0 8.7e-30 103.1 0.0 2.2 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.12 EPA05906.1 - 3e-12 46.0 0.0 5.2e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain DUF695 PF05117.7 EPA05906.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF695) GCOM2 PF15328.1 EPA05908.1 - 0.016 15.0 0.4 0.018 14.8 0.3 1.1 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 Vps4_C PF09336.5 EPA05908.1 - 0.036 13.9 0.1 0.053 13.4 0.1 1.3 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain DUF4363 PF14276.1 EPA05908.1 - 0.041 13.5 1.2 0.079 12.6 0.5 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4363) Snf7 PF03357.16 EPA05908.1 - 0.043 13.1 0.5 0.064 12.6 0.4 1.2 1 0 0 1 1 1 0 Snf7 Ferritin PF00210.19 EPA05908.1 - 0.15 11.7 1.5 0.2 11.3 0.2 1.7 2 0 0 2 2 2 0 Ferritin-like domain DnaI_N PF07319.6 EPA05908.1 - 0.19 11.9 2.0 0.68 10.2 0.3 2.1 1 1 1 2 2 2 0 Primosomal protein DnaI N-terminus PHP_C PF13263.1 EPA05909.1 - 1.1e-09 37.6 0.0 2.7e-09 36.3 0.0 1.7 1 0 0 1 1 1 1 PHP-associated PHP PF02811.14 EPA05909.1 - 4.2e-07 29.9 0.5 5.5e-07 29.5 0.4 1.1 1 0 0 1 1 1 1 PHP domain DUF1933 PF09147.5 EPA05909.1 - 0.01 15.2 0.1 0.016 14.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1933) CNPase PF05881.7 EPA05909.1 - 0.051 12.9 0.0 0.09 12.1 0.0 1.4 1 0 0 1 1 1 0 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) Methyltransf_33 PF10017.4 EPA05910.1 - 1.3e-44 151.1 1.1 2e-44 150.5 0.8 1.4 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Methyltransf_23 PF13489.1 EPA05910.1 - 0.00012 21.8 0.0 0.002 17.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 EPA05910.1 - 0.0074 15.9 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain F420_ligase PF01996.11 EPA05911.1 - 4.6e-67 225.4 0.7 5.2e-67 225.2 0.5 1.0 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase Hydrolase PF00702.21 EPA05912.1 - 3.1e-08 34.2 0.1 7.6e-08 33.0 0.1 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EPA05912.1 - 4.3e-06 27.0 0.0 7.5e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.2 EPA05912.1 - 1.9e-05 24.9 0.2 2.7e-05 24.4 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EPA05912.1 - 9e-05 22.1 0.7 0.00088 18.9 0.4 2.2 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase DS PF01916.12 EPA05913.1 - 4.7e-41 140.8 0.3 5.7e-41 140.5 0.2 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase ABC_tran PF00005.22 EPA05914.1 - 9.1e-34 116.7 0.1 1.3e-33 116.2 0.1 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.7 EPA05914.1 - 5.6e-18 65.0 0.2 1.2e-17 63.9 0.1 1.6 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.1 EPA05914.1 - 3.5e-06 27.2 3.4 0.0029 17.6 0.4 2.2 1 1 1 2 2 2 2 AAA domain SMC_N PF02463.14 EPA05914.1 - 2.4e-05 23.6 0.4 4.2e-05 22.8 0.2 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 EPA05914.1 - 9.7e-05 21.6 0.2 0.00022 20.4 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 EPA05914.1 - 0.0001 22.3 0.0 0.00014 21.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.1 EPA05914.1 - 0.00019 21.7 0.5 0.00037 20.7 0.4 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EPA05914.1 - 0.00029 20.9 0.8 0.0044 17.1 0.5 2.2 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.1 EPA05914.1 - 0.0003 19.9 7.5 0.16 11.0 2.6 2.2 2 0 0 2 2 2 2 AAA ATPase domain T2SE PF00437.15 EPA05914.1 - 0.00037 19.4 0.3 0.00063 18.7 0.2 1.5 1 1 0 1 1 1 1 Type II/IV secretion system protein AAA_10 PF12846.2 EPA05914.1 - 0.00041 19.8 0.0 0.0015 18.0 0.0 2.0 1 1 0 1 1 1 1 AAA-like domain AAA_29 PF13555.1 EPA05914.1 - 0.00049 19.5 0.1 0.001 18.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.7 EPA05914.1 - 0.00053 19.1 0.0 0.00099 18.2 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA PF00004.24 EPA05914.1 - 0.00077 19.6 0.6 0.015 15.5 0.4 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EPA05914.1 - 0.0019 18.9 0.6 0.0052 17.5 0.4 2.1 1 1 0 1 1 1 1 AAA domain UPF0079 PF02367.12 EPA05914.1 - 0.0039 16.8 0.0 0.0072 15.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 EPA05914.1 - 0.011 15.9 0.0 0.023 14.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.21 EPA05914.1 - 0.012 15.1 0.1 0.027 13.9 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.1 EPA05914.1 - 0.012 15.0 0.0 0.021 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.1 EPA05914.1 - 0.015 13.8 0.0 3.3 6.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain KaiC PF06745.8 EPA05914.1 - 0.015 14.4 0.3 0.11 11.5 0.1 2.1 2 0 0 2 2 2 0 KaiC ATP-synt_ab PF00006.20 EPA05914.1 - 0.016 14.6 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_19 PF13245.1 EPA05914.1 - 0.023 14.4 0.0 0.077 12.7 0.0 1.8 2 0 0 2 2 1 0 Part of AAA domain AAA_23 PF13476.1 EPA05914.1 - 0.024 14.9 4.7 0.099 12.9 3.2 2.0 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 EPA05914.1 - 0.031 13.7 0.3 0.1 12.0 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF87 PF01935.12 EPA05914.1 - 0.051 13.4 0.5 0.051 13.4 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF87 NB-ARC PF00931.17 EPA05914.1 - 0.057 12.2 0.1 0.081 11.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_5 PF07728.9 EPA05914.1 - 0.066 12.9 0.0 0.21 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.1 EPA05914.1 - 0.073 13.1 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain PRK PF00485.13 EPA05914.1 - 0.074 12.6 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family APS_kinase PF01583.15 EPA05914.1 - 0.081 12.5 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_14 PF13173.1 EPA05914.1 - 0.081 12.8 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 EPA05914.1 - 0.089 12.7 0.0 0.15 11.9 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.1 EPA05914.1 - 0.099 12.5 0.1 0.51 10.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EPA05914.1 - 0.1 11.7 0.0 0.22 10.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF3647 PF12363.3 EPA05916.1 - 0.067 13.2 0.6 0.097 12.7 0.4 1.3 1 0 0 1 1 1 0 Phage protein HGTP_anticodon PF03129.15 EPA05917.1 - 3e-17 62.3 0.2 3e-17 62.3 0.2 2.0 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.20 EPA05917.1 - 8.2e-17 61.3 0.2 1.9e-16 60.1 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) NAD_binding_5 PF07994.7 EPA05918.1 - 0.0011 18.5 0.1 0.0011 18.5 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase LysE PF01810.13 EPA05919.1 - 3.9e-29 101.3 16.0 4.9e-29 100.9 11.1 1.0 1 0 0 1 1 1 1 LysE type translocator NAD_binding_5 PF07994.7 EPA05920.1 - 3.6e-32 112.0 0.0 3e-31 108.9 0.0 1.9 1 1 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 EPA05920.1 - 6.1e-31 106.5 0.5 8.9e-30 102.7 0.0 2.2 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase DUF257 PF03192.8 EPA05920.1 - 0.028 13.7 0.3 0.19 11.0 0.0 2.0 2 0 0 2 2 2 0 Pyrococcus protein of unknown function, DUF257 CobU PF02283.11 EPA05920.1 - 0.053 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase PAC2 PF09754.4 EPA05921.1 - 2.7e-20 73.1 0.0 3.3e-20 72.8 0.0 1.0 1 0 0 1 1 1 1 PAC2 family DUF2216 PF10226.4 EPA05923.1 - 0.07 12.6 0.2 0.084 12.3 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized conserved proteins (DUF2216) SMC_N PF02463.14 EPA05924.1 - 3.3e-55 186.6 34.1 1.8e-32 112.3 0.0 3.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EPA05924.1 - 6e-18 64.9 0.0 2.5e-17 62.9 0.0 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 EPA05924.1 - 4e-13 50.1 35.1 4e-13 50.1 24.3 7.2 2 2 3 5 5 3 1 AAA domain AAA_21 PF13304.1 EPA05924.1 - 4.4e-09 36.7 17.9 3.7e-07 30.3 1.6 5.0 2 2 0 4 4 4 2 AAA domain AAA_29 PF13555.1 EPA05924.1 - 5.3e-06 25.8 0.0 1.3e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Tubulin_3 PF14881.1 EPA05924.1 - 0.0011 18.5 0.1 0.0071 15.8 0.1 2.5 1 0 0 1 1 1 1 Tubulin domain SbcCD_C PF13558.1 EPA05924.1 - 0.013 15.4 0.0 0.081 12.8 0.0 2.5 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 EPA05924.1 - 0.06 12.7 0.0 0.51 9.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 EPA05924.1 - 0.12 12.3 0.0 0.12 12.3 0.0 3.3 3 2 0 3 3 3 0 AAA ATPase domain APG6 PF04111.7 EPA05924.1 - 6.3 5.7 105.8 0.019 13.9 9.0 7.5 3 2 5 8 8 8 0 Autophagy protein Apg6 IncA PF04156.9 EPA05924.1 - 9.6 5.7 110.6 0.014 14.9 14.8 6.9 3 2 3 7 7 7 0 IncA protein DS PF01916.12 EPA05925.1 - 9.1e-07 28.2 0.0 9.4e-07 28.2 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Alba PF01918.16 EPA05926.1 - 1.7e-11 43.5 1.6 2.1e-11 43.2 1.1 1.2 1 0 0 1 1 1 1 Alba Rpp20 PF12328.3 EPA05926.1 - 0.098 12.3 1.2 0.5 10.0 0.2 2.0 1 1 1 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P FGE-sulfatase PF03781.11 EPA05927.1 - 2.2e-41 141.9 5.3 3.9e-41 141.1 3.7 1.3 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.2 EPA05927.1 - 1.3e-11 44.9 0.1 5.3e-11 42.9 0.0 2.0 2 0 0 2 2 2 1 DinB superfamily DinB PF05163.7 EPA05927.1 - 0.072 12.7 0.2 0.22 11.1 0.1 1.9 1 1 0 1 1 1 0 DinB family E3_UbLigase_R4 PF13764.1 EPA05927.1 - 3.1 5.5 4.8 0.62 7.8 1.1 1.4 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase UBR4 Prok-JAB PF14464.1 EPA05928.1 - 4.3e-19 68.0 0.0 5.2e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain JAB PF01398.16 EPA05928.1 - 5.5e-12 45.4 0.1 7.1e-12 45.0 0.1 1.1 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RadC PF04002.10 EPA05928.1 - 0.0022 17.6 0.3 0.0058 16.3 0.2 1.7 1 1 0 1 1 1 1 RadC-like JAB domain Toxin-JAB1 PF15659.1 EPA05928.1 - 0.041 13.7 0.5 0.077 12.8 0.1 1.6 1 1 0 1 1 1 0 JAB-like toxin 1 TylF PF05711.6 EPA05928.1 - 0.098 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) UbiA PF01040.13 EPA05929.1 - 5.4e-28 97.9 23.6 6.9e-28 97.5 16.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF4231 PF14015.1 EPA05929.1 - 0.68 9.9 0.0 0.68 9.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) DUF2024 PF09630.5 EPA05930.1 - 4.4e-39 132.0 1.3 4.9e-39 131.9 0.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2024) CCG PF02754.11 EPA05930.1 - 0.055 13.4 0.1 0.083 12.9 0.1 1.2 1 0 0 1 1 1 0 Cysteine-rich domain Cytochrom_NNT PF03264.9 EPA05930.1 - 0.069 12.5 0.3 0.071 12.5 0.2 1.1 1 0 0 1 1 1 0 NapC/NirT cytochrome c family, N-terminal region RE_TdeIII PF09520.5 EPA05930.1 - 0.11 11.7 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease, TdeIII DUF108 PF01958.13 EPA05932.1 - 1.9e-33 114.5 0.9 2.9e-33 113.9 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF108 NAD_binding_3 PF03447.11 EPA05932.1 - 2.8e-09 37.3 0.1 5.6e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain zf-ribbon_3 PF13248.1 EPA05933.1 - 0.11 11.7 0.4 0.11 11.7 0.3 3.9 4 0 0 4 4 4 0 zinc-ribbon domain PolC_DP2 PF03833.8 EPA05933.1 - 0.34 8.5 12.0 0.38 8.3 8.4 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DUF1610 PF07754.6 EPA05933.1 - 0.37 10.9 26.1 0.32 11.1 6.4 3.5 3 2 0 3 3 3 0 Domain of unknown function (DUF1610) NadA PF02445.11 EPA05934.1 - 1.2e-113 378.8 2.0 1.3e-113 378.6 1.4 1.0 1 0 0 1 1 1 1 Quinolinate synthetase A protein Methyltransf_3 PF01596.12 EPA05935.1 - 1.1e-38 132.3 0.3 2.1e-38 131.4 0.2 1.4 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.1 EPA05935.1 - 8.2e-15 55.5 0.0 1.4e-14 54.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA05935.1 - 7.9e-11 42.5 0.0 1.6e-10 41.5 0.0 1.5 2 0 0 2 2 1 1 Methyltransferase domain PCMT PF01135.14 EPA05935.1 - 7e-08 32.2 0.1 3.1e-07 30.1 0.0 1.9 2 1 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 EPA05935.1 - 1.8e-07 30.8 0.3 3.3e-07 30.0 0.2 1.4 1 1 0 1 1 1 1 Methyltransferase domain CmcI PF04989.7 EPA05935.1 - 1.3e-05 24.6 0.1 1.6e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_26 PF13659.1 EPA05935.1 - 1.5e-05 24.9 0.0 5.1e-05 23.2 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain CMAS PF02353.15 EPA05935.1 - 0.00011 21.3 0.1 0.00013 21.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_15 PF09445.5 EPA05935.1 - 0.00015 21.3 0.0 0.00027 20.5 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.10 EPA05935.1 - 0.0016 17.8 0.1 0.0028 17.0 0.1 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.1 EPA05935.1 - 0.0031 17.8 0.0 0.06 13.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA05935.1 - 0.0051 17.2 0.0 0.035 14.5 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 EPA05935.1 - 0.0061 15.9 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.13 EPA05935.1 - 0.014 14.9 0.2 0.019 14.5 0.1 1.3 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 GCD14 PF08704.5 EPA05935.1 - 0.02 14.3 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit PTH2 PF01981.11 EPA05936.1 - 6e-44 148.4 0.1 6.7e-44 148.2 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Pro_dh PF01619.13 EPA05937.1 - 4e-32 111.4 0.0 4.9e-32 111.1 0.0 1.0 1 0 0 1 1 1 1 Proline dehydrogenase Peptidase_M15_2 PF05951.8 EPA05937.1 - 0.056 12.8 0.4 0.18 11.2 0.1 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF882) Toprim_3 PF13362.1 EPA05937.1 - 0.13 12.4 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Toprim domain Pyr_redox_2 PF07992.9 EPA05938.1 - 0.0002 21.2 0.0 0.00022 21.1 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EPA05938.1 - 0.00064 19.6 0.2 0.0012 18.7 0.1 1.6 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EPA05938.1 - 0.0028 16.2 0.8 0.0096 14.4 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.12 EPA05938.1 - 0.0037 16.3 0.0 0.0037 16.3 0.0 1.2 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.19 EPA05938.1 - 0.017 14.0 0.0 0.017 14.0 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.2 EPA05938.1 - 0.03 13.3 0.2 0.03 13.3 0.1 1.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase DAO PF01266.19 EPA05938.1 - 0.035 12.9 0.0 0.035 12.9 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Amino_oxidase PF01593.19 EPA05938.1 - 0.049 12.6 0.1 0.11 11.5 0.0 1.5 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase SprT-like PF10263.4 EPA05939.1 - 0.0018 17.9 0.0 0.0021 17.6 0.0 1.2 1 0 0 1 1 1 1 SprT-like family DUF45 PF01863.12 EPA05939.1 - 0.0038 17.0 0.0 0.0081 15.9 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function DUF45 WLM PF08325.5 EPA05939.1 - 0.049 13.4 0.1 0.068 13.0 0.0 1.3 1 0 0 1 1 1 0 WLM domain Peptidase_M76 PF09768.4 EPA05939.1 - 0.056 12.9 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 Peptidase M76 family H_PPase PF03030.11 EPA05940.1 - 3.3e-223 742.8 51.9 3.8e-223 742.6 36.0 1.0 1 0 0 1 1 1 1 Inorganic H+ pyrophosphatase Peptidase_M50 PF02163.17 EPA05940.1 - 0.11 11.4 3.7 3.2 6.6 1.9 3.5 2 2 0 2 2 2 0 Peptidase family M50 PepSY_TM_1 PF13172.1 EPA05940.1 - 0.13 12.0 0.2 0.13 12.0 0.2 3.8 4 0 0 4 4 4 0 PepSY-associated TM helix Cu-oxidase_3 PF07732.10 EPA05942.1 - 4.7e-44 148.8 1.2 1.6e-34 118.1 0.0 2.3 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 EPA05942.1 - 1.1e-33 115.6 0.9 8e-24 83.7 0.4 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 EPA05942.1 - 6.5e-17 61.8 0.0 2.9e-16 59.7 0.0 1.9 2 1 0 2 2 2 1 Multicopper oxidase Cupredoxin_1 PF13473.1 EPA05942.1 - 3e-16 59.1 0.8 1.7e-10 40.7 0.1 3.9 3 2 0 3 3 3 3 Cupredoxin-like domain Copper-bind PF00127.15 EPA05942.1 - 3.9e-08 33.4 0.3 0.0015 18.6 0.0 3.5 3 1 0 3 3 3 2 Copper binding proteins, plastocyanin/azurin family SoxE PF06525.6 EPA05942.1 - 0.00027 20.2 1.4 0.0027 17.0 0.1 2.8 2 1 0 3 3 3 1 Sulfocyanin (SoxE) GnsAB PF08178.6 EPA05942.1 - 0.17 11.5 1.3 0.4 10.3 0.9 1.6 1 0 0 1 1 1 0 GnsA/GnsB family DUF359 PF04019.7 EPA05943.1 - 1.3e-32 111.7 0.0 1.7e-32 111.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF359) TruD PF01142.13 EPA05944.1 - 6.4e-21 74.4 0.1 6.7e-21 74.3 0.1 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) QRPTase_C PF01729.14 EPA05946.1 - 1.4e-56 190.6 1.2 1.6e-56 190.4 0.8 1.0 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain Ribul_P_3_epim PF00834.14 EPA05946.1 - 0.0035 16.4 0.1 0.0066 15.5 0.1 1.5 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family Glu_synthase PF01645.12 EPA05946.1 - 0.023 13.6 0.1 0.12 11.2 0.0 2.0 2 0 0 2 2 2 0 Conserved region in glutamate synthase AAA_5 PF07728.9 EPA05946.1 - 0.029 14.0 0.1 0.054 13.2 0.1 1.5 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) Ssl1 PF04056.9 EPA05946.1 - 0.072 12.6 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 Ssl1-like Spt4 PF06093.8 EPA05947.1 - 1.3e-13 50.5 0.5 1.6e-13 50.2 0.3 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger RecR PF02132.10 EPA05947.1 - 0.0059 16.0 1.1 0.0078 15.6 0.7 1.1 1 0 0 1 1 1 1 RecR protein Laminin_EGF PF00053.19 EPA05947.1 - 0.11 12.4 0.5 0.14 12.1 0.4 1.2 1 0 0 1 1 1 0 Laminin EGF-like (Domains III and V) TF_Zn_Ribbon PF08271.7 EPA05947.1 - 0.13 11.5 1.4 0.15 11.3 0.0 1.8 2 0 0 2 2 2 0 TFIIB zinc-binding RPA_interact_C PF14768.1 EPA05947.1 - 0.19 12.1 1.5 0.97 9.8 0.0 2.1 2 0 0 2 2 2 0 Replication protein A interacting C-terminal zf-C3HC4_3 PF13920.1 EPA05947.1 - 0.37 10.4 3.4 0.52 10.0 2.3 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EPA05947.1 - 0.73 9.6 3.5 1 9.1 2.4 1.2 1 0 0 1 1 1 0 zinc-RING finger domain Prim_Zn_Ribbon PF08273.7 EPA05947.1 - 1.4 9.0 3.9 1.8 8.7 0.2 2.1 1 1 1 2 2 2 0 Zinc-binding domain of primase-helicase SGL PF08450.7 EPA05948.1 - 1.4e-09 37.6 1.5 0.08 12.3 0.0 4.2 1 1 1 4 4 4 4 SMP-30/Gluconolaconase/LRE-like region NHL PF01436.16 EPA05948.1 - 5.9e-06 25.9 0.0 0.0018 18.1 0.0 3.2 3 0 0 3 3 3 1 NHL repeat Reg_prop PF07494.6 EPA05948.1 - 0.0032 17.2 4.1 14 6.1 0.0 4.6 4 0 0 4 4 4 1 Two component regulator propeller Str_synth PF03088.11 EPA05948.1 - 0.007 16.3 0.0 8.9 6.4 0.0 4.0 3 1 1 4 4 4 1 Strictosidine synthase PQQ_3 PF13570.1 EPA05948.1 - 0.05 13.9 0.1 12 6.3 0.0 3.5 4 0 0 4 4 4 0 PQQ-like domain EF_assoc_1 PF08355.7 EPA05948.1 - 0.12 11.6 0.0 0.12 11.6 0.0 2.1 3 0 0 3 3 3 0 EF hand associated Copper-bind PF00127.15 EPA05949.1 - 6.7e-16 58.3 0.6 7.3e-08 32.5 0.1 2.7 2 1 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 EPA05949.1 - 1e-12 47.8 0.1 1e-06 28.5 0.0 2.4 2 0 0 2 2 2 2 Cupredoxin-like domain DUF2178 PF09946.4 EPA05949.1 - 1.7 8.4 9.0 0.34 10.6 3.5 2.0 2 1 0 2 2 2 0 Predicted membrane protein (DUF2178) TPR_11 PF13414.1 EPA05950.1 - 1.2e-18 66.4 0.3 4.7e-09 35.7 0.0 2.1 1 1 2 3 3 3 3 TPR repeat TPR_1 PF00515.23 EPA05950.1 - 2.3e-13 49.0 1.1 4.2e-05 22.9 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 EPA05950.1 - 2.1e-12 47.1 0.0 1.7e-08 34.6 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 EPA05950.1 - 2.5e-12 46.5 0.1 4.3e-07 29.7 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 EPA05950.1 - 5.6e-12 44.6 0.0 0.00019 21.1 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 EPA05950.1 - 4.7e-11 41.6 2.0 0.00026 20.5 0.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 EPA05950.1 - 2.3e-10 40.4 0.2 3.3e-10 39.9 0.1 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 EPA05950.1 - 2.7e-07 31.0 0.0 3.6e-06 27.4 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 EPA05950.1 - 2.1e-05 24.3 0.1 0.014 15.5 0.0 3.1 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 EPA05950.1 - 8.7e-05 22.0 0.0 0.043 13.6 0.0 2.6 2 1 1 3 3 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 EPA05950.1 - 0.00026 21.2 0.0 0.17 12.4 0.0 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EPA05950.1 - 0.0011 19.4 0.0 6.2 7.7 0.0 3.1 1 1 2 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EPA05950.1 - 0.0012 18.6 0.5 2.1 8.3 0.0 3.1 1 1 2 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat DUF4284 PF14112.1 EPA05950.1 - 0.017 15.5 0.9 0.42 11.0 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4284) ChAPs PF09295.5 EPA05950.1 - 0.022 13.5 0.1 0.024 13.3 0.1 1.1 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_3 PF07720.7 EPA05950.1 - 0.024 14.4 5.1 0.058 13.2 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Clathrin PF00637.15 EPA05950.1 - 0.058 13.0 1.1 0.086 12.4 0.8 1.3 1 0 0 1 1 1 0 Region in Clathrin and VPS Cas_Cas02710 PF09670.5 EPA05950.1 - 0.059 11.9 0.0 0.068 11.7 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) P4Ha_N PF08336.6 EPA05950.1 - 0.068 12.9 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region FIVAR PF07554.8 EPA05950.1 - 1.1 9.5 0.1 1.1 9.5 0.1 2.7 4 0 0 4 4 3 0 Uncharacterised Sugar-binding Domain EF1_GNE PF00736.14 EPA05952.1 - 1.2e-22 79.4 0.5 1.3e-22 79.2 0.4 1.0 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain DUF4390 PF14334.1 EPA05952.1 - 0.15 11.2 0.0 11 5.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4390) Cyclophil_like PF04126.8 EPA05953.1 - 2.4e-38 130.4 0.0 3e-38 130.1 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin-like DUF3830 PF12903.2 EPA05953.1 - 0.012 14.9 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3830) NSP2_assoc PF14758.1 EPA05953.1 - 0.15 12.1 0.0 0.19 11.8 0.0 1.1 1 0 0 1 1 1 0 Non-essential region of nsp2 of arterivirus polyprotein ParA PF10609.4 EPA05954.1 - 5.3e-36 122.3 0.2 1.6e-35 120.8 0.2 1.8 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 EPA05954.1 - 6.2e-20 71.4 0.1 9.8e-20 70.7 0.1 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF59 PF01883.14 EPA05954.1 - 5.8e-18 64.6 1.2 1.3e-17 63.5 0.1 2.2 3 0 0 3 3 3 1 Domain of unknown function DUF59 AAA_31 PF13614.1 EPA05954.1 - 1.6e-11 44.3 0.6 6.9e-11 42.3 0.0 2.2 3 0 0 3 3 3 1 AAA domain MipZ PF09140.6 EPA05954.1 - 2e-08 33.6 0.0 3.5e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 ATPase MipZ AAA_26 PF13500.1 EPA05954.1 - 3.8e-07 29.9 0.5 0.0048 16.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain ArsA_ATPase PF02374.10 EPA05954.1 - 1.2e-05 24.5 1.5 2.7e-05 23.3 0.6 1.8 2 0 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.13 EPA05954.1 - 1.6e-05 24.2 0.1 0.001 18.3 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family VirC1 PF07015.6 EPA05954.1 - 0.0019 17.2 0.0 0.0051 15.9 0.0 1.7 1 0 0 1 1 1 1 VirC1 protein ArgK PF03308.11 EPA05954.1 - 0.017 13.9 0.4 0.027 13.2 0.3 1.3 1 0 0 1 1 1 0 ArgK protein AAA_25 PF13481.1 EPA05954.1 - 0.018 14.4 0.5 0.042 13.2 0.3 1.6 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.15 EPA05954.1 - 0.07 12.7 0.1 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase QRPTase_N PF02749.11 EPA05955.1 - 1.4e-18 66.5 0.0 1.7e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain Ppx-GppA PF02541.11 EPA05955.1 - 0.074 12.2 0.0 0.074 12.2 0.0 1.1 1 0 0 1 1 1 0 Ppx/GppA phosphatase family Ufm1 PF03671.9 EPA05955.1 - 0.11 12.2 0.1 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin fold modifier 1 protein AAA PF00004.24 EPA05956.1 - 1.4e-91 303.5 0.1 3.6e-48 163.1 0.0 3.1 4 0 0 4 4 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 EPA05956.1 - 2.6e-26 91.3 0.7 9.9e-26 89.5 0.5 2.1 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.7 EPA05956.1 - 3.8e-15 55.5 0.1 1.7e-08 33.7 0.0 2.8 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EPA05956.1 - 1.7e-13 51.4 0.1 1e-05 26.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.9 EPA05956.1 - 3.1e-13 49.9 0.0 1.2e-07 31.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 EPA05956.1 - 7.2e-13 48.5 0.0 5.3e-07 29.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 EPA05956.1 - 2e-12 47.3 0.3 0.0051 16.9 0.0 4.5 2 2 1 3 3 3 2 AAA domain AAA_16 PF13191.1 EPA05956.1 - 2.3e-12 47.3 0.0 0.00034 20.6 0.0 3.7 2 1 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.9 EPA05956.1 - 3.5e-11 42.9 0.6 0.00015 21.5 0.0 4.5 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) Arch_ATPase PF01637.13 EPA05956.1 - 6.1e-10 39.2 0.1 0.00081 19.1 0.0 3.7 2 1 1 3 3 3 3 Archaeal ATPase AAA_18 PF13238.1 EPA05956.1 - 1.1e-09 38.6 0.6 0.0011 19.2 0.0 3.1 4 0 0 4 4 2 2 AAA domain RNA_helicase PF00910.17 EPA05956.1 - 1.4e-09 38.0 0.0 0.0014 18.7 0.0 3.0 3 0 0 3 3 2 2 RNA helicase CDC48_2 PF02933.12 EPA05956.1 - 1.1e-08 34.6 0.3 3.6e-08 32.9 0.1 2.0 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.1 EPA05956.1 - 1.2e-08 34.8 0.0 0.0016 18.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.22 EPA05956.1 - 1.6e-08 34.9 0.1 0.0089 16.3 0.0 3.5 2 1 0 2 2 2 2 ABC transporter AAA_25 PF13481.1 EPA05956.1 - 1.7e-08 34.0 4.8 0.1 12.0 0.1 4.7 2 2 2 5 5 5 3 AAA domain Sigma54_activ_2 PF14532.1 EPA05956.1 - 1.8e-07 31.2 0.0 0.018 15.0 0.0 3.0 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_28 PF13521.1 EPA05956.1 - 2e-07 31.1 0.0 0.024 14.6 0.0 2.7 3 0 0 3 3 2 2 AAA domain IstB_IS21 PF01695.12 EPA05956.1 - 3.2e-07 29.9 0.1 0.031 13.7 0.0 2.9 3 0 0 3 3 2 2 IstB-like ATP binding protein Zeta_toxin PF06414.7 EPA05956.1 - 4.2e-07 29.2 0.0 0.015 14.4 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin Mg_chelatase PF01078.16 EPA05956.1 - 8.5e-07 28.3 0.5 0.016 14.3 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ATP-synt_ab PF00006.20 EPA05956.1 - 4.5e-06 26.3 0.1 0.14 11.6 0.0 3.3 2 1 1 3 3 3 2 ATP synthase alpha/beta family, nucleotide-binding domain TIP49 PF06068.8 EPA05956.1 - 4.6e-06 25.6 0.1 0.013 14.2 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus AAA_19 PF13245.1 EPA05956.1 - 6.2e-06 25.8 1.0 0.081 12.6 0.0 2.8 2 0 0 2 2 2 2 Part of AAA domain Rad17 PF03215.10 EPA05956.1 - 8.9e-06 24.6 0.0 0.074 11.7 0.0 2.4 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein Sigma54_activat PF00158.21 EPA05956.1 - 1.4e-05 24.6 0.0 1 8.8 0.0 3.9 3 1 0 3 3 3 2 Sigma-54 interaction domain AAA_24 PF13479.1 EPA05956.1 - 3.3e-05 23.5 0.1 0.31 10.5 0.1 2.8 2 0 0 2 2 2 2 AAA domain KaiC PF06745.8 EPA05956.1 - 4.9e-05 22.5 0.8 0.4 9.7 0.0 3.6 2 1 1 3 3 3 2 KaiC NACHT PF05729.7 EPA05956.1 - 6e-05 22.7 0.7 1.8 8.1 0.0 3.6 4 0 0 4 4 3 2 NACHT domain PhoH PF02562.11 EPA05956.1 - 0.00028 20.1 0.6 1.6 7.9 0.1 3.7 3 0 0 3 3 3 1 PhoH-like protein Viral_helicase1 PF01443.13 EPA05956.1 - 0.00033 20.2 0.0 0.14 11.6 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.4 EPA05956.1 - 0.00052 19.1 0.0 0.69 8.8 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.6 EPA05956.1 - 0.001 18.6 0.0 2.5 7.6 0.0 3.2 4 1 0 4 4 2 1 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.5 EPA05956.1 - 0.0013 17.9 0.0 1.9 7.6 0.0 3.3 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit Cytidylate_kin2 PF13189.1 EPA05956.1 - 0.0015 18.4 0.0 1.8 8.4 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase-like family SKI PF01202.17 EPA05956.1 - 0.0015 18.3 0.1 2.1 8.2 0.0 3.0 3 0 0 3 3 3 1 Shikimate kinase Parvo_NS1 PF01057.12 EPA05956.1 - 0.0018 17.1 0.1 1.5 7.6 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 ResIII PF04851.10 EPA05956.1 - 0.0024 17.7 0.0 0.23 11.2 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_11 PF13086.1 EPA05956.1 - 0.0047 16.5 0.0 1.1 8.7 0.0 2.6 2 1 0 2 2 2 1 AAA domain KAP_NTPase PF07693.9 EPA05956.1 - 0.0065 15.4 0.0 1.2 8.0 0.0 3.0 2 1 1 3 3 3 1 KAP family P-loop domain DUF815 PF05673.8 EPA05956.1 - 0.0083 15.0 0.0 5 5.9 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF815) NB-ARC PF00931.17 EPA05956.1 - 0.013 14.3 0.7 4.1 6.1 0.0 3.0 3 0 0 3 3 3 0 NB-ARC domain AAA_23 PF13476.1 EPA05956.1 - 0.035 14.4 0.1 3.7 7.8 0.0 2.8 3 0 0 3 3 2 0 AAA domain UPF0079 PF02367.12 EPA05956.1 - 0.037 13.6 0.1 7.1 6.2 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 IPT PF01745.11 EPA05956.1 - 0.049 12.8 0.1 0.51 9.4 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase KTI12 PF08433.5 EPA05956.1 - 0.058 12.5 0.0 10 5.2 0.0 3.0 3 0 0 3 3 3 0 Chromatin associated protein KTI12 NTPase_1 PF03266.10 EPA05956.1 - 0.077 12.7 1.1 17 5.0 0.0 3.7 2 2 1 3 3 3 0 NTPase AAA_21 PF13304.1 EPA05956.1 - 0.087 12.7 1.1 25 4.7 0.0 3.1 2 1 0 2 2 2 0 AAA domain AAA_13 PF13166.1 EPA05956.1 - 0.19 10.1 0.0 6.8 5.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Aldedh PF00171.17 EPA05957.1 - 5.8e-136 453.4 0.0 7.1e-136 453.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EPA05957.1 - 0.054 12.1 0.1 0.2 10.3 0.1 1.9 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) FAD_binding_3 PF01494.14 EPA05958.1 - 0.0086 15.1 0.0 0.0098 14.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain SHS2_Rpb7-N PF03876.12 EPA05959.1 - 1.6e-15 56.9 0.0 4.4e-15 55.5 0.0 1.7 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 EPA05959.1 - 2.9e-14 52.9 0.0 4.6e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain S1_2 PF13509.1 EPA05959.1 - 0.017 15.0 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 S1 domain BPL_C PF02237.12 EPA05959.1 - 0.031 13.9 0.0 0.068 12.8 0.0 1.5 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Arginase PF00491.16 EPA05960.1 - 1.7e-60 204.6 0.0 1.9e-60 204.4 0.0 1.0 1 0 0 1 1 1 1 Arginase family PrgI PF12666.2 EPA05961.1 - 5.9 7.1 9.4 0.63 10.2 0.4 3.3 2 1 1 3 3 3 0 PrgI family protein Usp PF00582.21 EPA05962.1 - 2.3e-06 27.8 0.0 2.6e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family GST_C PF00043.20 EPA05962.1 - 0.038 13.9 0.1 0.046 13.7 0.1 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain COP-gamma_platf PF08752.5 EPA05962.1 - 0.044 13.6 0.1 0.075 12.8 0.0 1.4 1 0 0 1 1 1 0 Coatomer gamma subunit appendage platform subdomain Selenoprotein_S PF06936.6 EPA05962.1 - 0.056 12.9 0.3 0.065 12.7 0.2 1.2 1 0 0 1 1 1 0 Selenoprotein S (SelS) ICE2 PF08426.5 EPA05962.1 - 0.083 11.4 0.1 0.083 11.4 0.1 1.1 1 0 0 1 1 1 0 ICE2 DUF3896 PF13035.1 EPA05962.1 - 0.22 11.5 3.0 0.72 9.9 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) ARD PF03079.9 EPA05963.1 - 0.013 15.5 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family Cupin_2 PF07883.6 EPA05963.1 - 0.073 12.5 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Cupin domain HgmA PF04209.8 EPA05963.1 - 0.1 10.9 0.0 0.12 10.7 0.0 1.0 1 0 0 1 1 1 0 homogentisate 1,2-dioxygenase DUF389 PF04087.9 EPA05964.1 - 7.4e-31 106.9 17.2 7.4e-31 106.9 12.0 2.7 3 1 0 3 3 3 1 Domain of unknown function (DUF389) PDT PF00800.13 EPA05965.1 - 1.7e-59 200.4 0.1 2.1e-59 200.1 0.1 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.20 EPA05965.1 - 0.00039 19.8 0.0 0.00065 19.1 0.0 1.4 1 0 0 1 1 1 1 ACT domain Thioredoxin_6 PF13848.1 EPA05965.1 - 0.037 13.8 0.4 0.058 13.1 0.2 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain B2-adapt-app_C PF09066.5 EPA05965.1 - 0.091 12.6 0.4 0.16 11.8 0.3 1.4 1 0 0 1 1 1 0 Beta2-adaptin appendage, C-terminal sub-domain Prok-RING_1 PF14446.1 EPA05966.1 - 0.00063 19.4 1.6 0.00086 18.9 1.1 1.1 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 NB PF04159.8 EPA05966.1 - 0.029 14.1 0.1 0.031 14.0 0.1 1.1 1 0 0 1 1 1 0 NB glycoprotein Ribosomal_L37e PF01907.14 EPA05966.1 - 0.046 13.5 0.3 0.057 13.2 0.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L37e DNA_RNApol_7kD PF03604.8 EPA05966.1 - 0.089 12.2 6.4 0.28 10.6 4.4 1.8 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Nudix_N_2 PF14803.1 EPA05966.1 - 0.58 9.8 3.0 3.9 7.2 0.1 2.2 2 0 0 2 2 2 0 Nudix N-terminal YhfH PF14149.1 EPA05966.1 - 1.9 8.3 4.7 6.5 6.6 3.3 1.8 1 1 1 2 2 2 0 YhfH-like protein Zn-ribbon_8 PF09723.5 EPA05966.1 - 4.5 7.3 5.5 4 7.4 0.4 2.0 1 1 0 1 1 1 0 Zinc ribbon domain PetM PF08041.6 EPA05968.1 - 0.21 11.1 0.2 0.21 11.1 0.2 1.7 2 0 0 2 2 2 0 PetM family of cytochrome b6f complex subunit 7 DNA_primase_lrg PF04104.9 EPA05969.1 - 3.9e-28 98.4 0.0 8.8e-28 97.2 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit DNA_primase_S PF01896.14 EPA05970.1 - 3.2e-11 43.2 1.7 9.3e-10 38.4 1.2 2.3 1 1 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit stn_TNFRSF12A PF12191.3 EPA05970.1 - 0.006 16.6 3.9 0.0099 15.9 2.7 1.3 1 0 0 1 1 1 1 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain PolC_DP2 PF03833.8 EPA05970.1 - 0.086 10.5 3.4 0.11 10.1 2.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 HypA PF01155.14 EPA05970.1 - 1.3 8.7 9.3 12 5.5 6.4 2.3 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family DNA_primase_S PF01896.14 EPA05971.1 - 7.6e-11 42.0 1.0 4.2e-09 36.3 0.7 2.4 1 1 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit stn_TNFRSF12A PF12191.3 EPA05971.1 - 0.0031 17.5 2.9 0.0053 16.7 2.0 1.3 1 0 0 1 1 1 1 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain PolC_DP2 PF03833.8 EPA05971.1 - 0.03 11.9 4.3 0.039 11.6 3.0 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 NRDD PF13597.1 EPA05971.1 - 0.058 11.4 3.7 0.079 11.0 1.4 1.8 2 0 0 2 2 2 0 Anaerobic ribonucleoside-triphosphate reductase YqzH PF14164.1 EPA05971.1 - 0.83 9.6 3.0 1.5 8.7 0.0 2.9 4 0 0 4 4 4 0 YqzH-like protein DUF3624 PF12292.3 EPA05971.1 - 3.1 8.2 5.0 0.55 10.6 1.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3624) DNA_primase_lrg PF04104.9 EPA05973.1 - 3.3e-25 88.8 0.1 5e-25 88.2 0.1 1.3 1 1 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit HATPase_c PF02518.21 EPA05974.1 - 9e-20 70.4 0.0 1.9e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EPA05974.1 - 1.2e-08 34.8 2.2 1.2e-08 34.7 0.1 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.1 EPA05974.1 - 8.6e-07 28.6 1.9 1.4e-06 27.9 0.0 2.2 2 1 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.1 EPA05974.1 - 9.1e-05 22.1 0.0 0.00026 20.6 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 EPA05974.1 - 0.0077 16.0 0.1 0.035 13.8 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain UPF0242 PF06785.6 EPA05974.1 - 3.6 6.1 16.1 4.8 5.7 11.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) DUF948 PF06103.6 EPA05974.1 - 4.1 7.3 10.4 3.7 7.4 1.2 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF629 PF04780.7 EPA05975.1 - 0.0017 16.9 1.0 0.0019 16.7 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF629) ComX PF05952.7 EPA05975.1 - 0.012 15.0 0.7 0.067 12.7 0.0 2.5 2 1 1 3 3 3 0 Bacillus competence pheromone ComX Cupin_4 PF08007.7 EPA05975.1 - 0.12 11.5 3.6 0.15 11.2 2.1 1.4 1 1 0 1 1 1 0 Cupin superfamily protein XPC-binding PF09280.6 EPA05975.1 - 0.15 11.5 13.2 0.56 9.7 0.7 3.0 2 1 0 2 2 2 0 XPC-binding domain Hormone_1 PF00103.15 EPA05975.1 - 0.25 10.6 5.0 0.32 10.3 3.5 1.3 1 1 0 1 1 1 0 Somatotropin hormone family Cauli_DNA-bind PF03310.8 EPA05975.1 - 0.3 10.9 1.7 1.7 8.5 0.1 2.3 2 1 0 2 2 2 0 Caulimovirus DNA-binding protein DUF849 PF05853.7 EPA05975.1 - 0.33 9.7 7.1 0.38 9.5 4.9 1.1 1 0 0 1 1 1 0 Prokaryotic protein of unknown function (DUF849) EF-hand_3 PF09069.6 EPA05975.1 - 0.58 10.2 6.8 2e+02 2.1 4.7 3.1 1 1 0 1 1 1 0 EF-hand Polysacc_deac_2 PF04748.8 EPA05975.1 - 2.2 7.2 11.4 0.41 9.6 1.1 2.1 1 1 1 2 2 2 0 Divergent polysaccharide deacetylase Topoisom_I_N PF02919.10 EPA05977.1 - 3.6e-43 147.3 4.8 4e-43 147.2 3.3 1.0 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, DNA binding fragment DsbD PF02683.10 EPA05978.1 - 0.0036 16.9 2.4 0.0077 15.8 1.7 1.5 2 0 0 2 2 2 1 Cytochrome C biogenesis protein transmembrane region AzlD PF05437.7 EPA05978.1 - 0.024 14.5 0.4 7.6 6.5 0.0 2.1 2 0 0 2 2 2 0 Branched-chain amino acid transport protein (AzlD) DUF2892 PF11127.3 EPA05978.1 - 0.18 11.6 2.0 0.32 10.8 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2892) DUF998 PF06197.8 EPA05978.1 - 0.19 11.0 2.6 0.073 12.3 0.3 1.3 2 0 0 2 2 2 0 Protein of unknown function (DUF998) TctB PF07331.6 EPA05978.1 - 0.9 9.1 4.1 2 8.0 0.1 2.3 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family DUF3953 PF13129.1 EPA05978.1 - 2.9 7.6 8.9 0.075 12.6 1.7 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3953) SurA_N_3 PF13624.1 EPA05979.1 - 0.044 13.7 0.4 0.057 13.4 0.3 1.1 1 0 0 1 1 1 0 SurA N-terminal domain Vma12 PF11712.3 EPA05979.1 - 0.11 12.1 0.5 0.13 11.9 0.4 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Mid2 PF04478.7 EPA05979.1 - 0.16 11.3 0.8 0.21 11.0 0.6 1.2 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Myb_DNA-bind_4 PF13837.1 EPA05980.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF1059 PF06348.6 EPA05981.1 - 4.1e-07 29.7 0.1 4.3e-07 29.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) CIDE-N PF02017.10 EPA05981.1 - 0.015 15.0 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 CIDE-N domain MAP PF03642.8 EPA05981.1 - 0.029 14.5 0.1 0.031 14.4 0.1 1.1 1 0 0 1 1 1 0 MAP domain Thioredoxin_3 PF13192.1 EPA05982.1 - 8.5e-17 60.7 0.2 9.9e-17 60.5 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin domain Glutaredoxin PF00462.19 EPA05982.1 - 1e-10 41.4 0.0 1.5e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.9 EPA05982.1 - 1.5e-05 25.1 0.0 1.5e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) KaiB PF07689.7 EPA05982.1 - 0.0029 17.0 0.0 0.0048 16.3 0.0 1.3 1 0 0 1 1 1 1 KaiB domain GST_N_3 PF13417.1 EPA05982.1 - 0.0051 16.9 0.0 0.006 16.7 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF1223 PF06764.6 EPA05982.1 - 0.028 14.2 0.1 0.56 9.9 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1223) ArsC PF03960.10 EPA05982.1 - 0.076 13.0 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 ArsC family HORMA PF02301.13 EPA05983.1 - 4.2e-06 26.3 0.6 4.2e-06 26.3 0.4 2.3 2 0 0 2 2 2 1 HORMA domain Laminin_II PF06009.7 EPA05983.1 - 0.019 14.7 2.5 0.019 14.7 1.7 2.0 2 1 0 2 2 2 0 Laminin Domain II Peptidase_S64 PF08192.6 EPA05983.1 - 0.024 13.0 15.1 0.029 12.6 10.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 HR1 PF02185.11 EPA05983.1 - 0.14 11.8 4.4 0.29 10.8 3.1 1.4 1 0 0 1 1 1 0 Hr1 repeat Daxx PF03344.10 EPA05983.1 - 0.3 9.5 29.8 0.42 9.0 20.7 1.2 1 0 0 1 1 1 0 Daxx Family DUF4407 PF14362.1 EPA05983.1 - 9.1 5.1 10.4 0.75 8.6 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Trypan_PARP PF05887.6 EPA05983.1 - 9.3 6.0 24.1 1 9.1 13.6 1.6 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) YHS PF04945.8 EPA05986.1 - 2.4e-17 62.4 0.5 2.5e-17 62.4 0.3 1.0 1 0 0 1 1 1 1 YHS domain zf-FCS PF06467.9 EPA05986.1 - 2.9e-05 23.6 0.3 3.4e-05 23.4 0.2 1.2 1 0 0 1 1 1 1 MYM-type Zinc finger with FCS sequence motif DUF581 PF04570.9 EPA05986.1 - 0.026 13.8 0.1 0.029 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF581) DUF2116 PF09889.4 EPA05986.1 - 0.097 12.4 1.2 0.72 9.6 0.8 1.9 1 1 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DEAD PF00270.24 EPA05987.1 - 2.1e-30 105.4 0.0 5e-30 104.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EPA05987.1 - 3.2e-15 55.7 0.8 7.3e-11 41.7 0.1 3.5 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DUF1998 PF09369.5 EPA05987.1 - 9.9e-12 45.2 0.1 2.9e-11 43.7 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) SNF2_N PF00176.18 EPA05987.1 - 0.0037 16.0 0.0 0.0063 15.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Elf1 PF05129.8 EPA05987.1 - 0.01 15.5 1.0 0.037 13.7 0.7 2.0 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.1 EPA05987.1 - 1.4 8.6 12.5 0.43 10.3 3.0 3.2 2 1 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 EPA05987.1 - 3.1 7.4 13.0 0.79 9.3 3.2 3.2 2 1 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 EPA05987.1 - 6.1 6.8 10.1 0.14 12.1 1.1 2.5 2 1 1 3 3 3 0 Zinc ribbon domain Response_reg PF00072.19 EPA05988.1 - 7.1e-25 87.2 0.5 1.6e-24 86.1 0.3 1.5 2 0 0 2 2 2 1 Response regulator receiver domain adh_short PF00106.20 EPA05989.1 - 4.4e-27 95.0 0.0 6.5e-27 94.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EPA05989.1 - 2.7e-22 79.7 0.0 3.6e-22 79.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EPA05989.1 - 6e-09 35.8 0.0 8.5e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.5 EPA05989.1 - 9.2e-08 31.5 0.1 1.5e-06 27.5 0.1 2.2 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) NmrA PF05368.8 EPA05989.1 - 0.0045 16.2 0.2 0.028 13.6 0.0 2.0 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.1 EPA05989.1 - 0.023 14.7 0.0 0.043 13.8 0.0 1.5 2 0 0 2 2 2 0 NADH(P)-binding DUF1951 PF09188.5 EPA05989.1 - 0.13 12.2 1.0 0.76 9.7 1.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1951) Response_reg PF00072.19 EPA05990.1 - 8.8e-24 83.6 0.1 1e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain Glyco_trans_4_2 PF13477.1 EPA05990.1 - 0.13 12.0 0.2 0.22 11.3 0.1 1.5 1 1 0 1 1 1 0 Glycosyl transferase 4-like TP_methylase PF00590.15 EPA05993.1 - 3.8e-52 177.0 0.0 4.3e-52 176.8 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Abhydrolase_2 PF02230.11 EPA05993.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase TP_methylase PF00590.15 EPA05998.1 - 5.9e-44 150.2 0.1 6.9e-44 150.0 0.1 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Aldolase PF01081.14 EPA05998.1 - 0.024 13.8 0.1 0.051 12.7 0.1 1.5 1 0 0 1 1 1 0 KDPG and KHG aldolase PrpR_N PF06506.6 EPA05998.1 - 0.033 13.6 0.8 0.54 9.6 0.1 2.3 2 1 0 2 2 2 0 Propionate catabolism activator V-ATPase_H_N PF03224.9 EPA05998.1 - 0.035 13.2 0.4 0.099 11.7 0.0 1.9 2 1 0 2 2 2 0 V-ATPase subunit H Radical_SAM PF04055.16 EPA05998.1 - 0.039 14.1 0.1 0.079 13.1 0.1 1.6 1 1 0 1 1 1 0 Radical SAM superfamily Tmemb_170 PF10190.4 EPA05998.1 - 0.1 12.6 0.9 0.19 11.8 0.1 1.9 2 0 0 2 2 2 0 Putative transmembrane protein 170 CitMHS PF03600.11 EPA05999.1 - 1.3e-41 142.3 46.0 1e-39 136.1 25.4 2.0 1 1 0 2 2 2 2 Citrate transporter ArsB PF02040.10 EPA05999.1 - 1.8e-15 56.8 38.7 6e-15 55.1 26.8 1.7 1 1 0 1 1 1 1 Arsenical pump membrane protein HGTP_anticodon PF03129.15 EPA06000.1 - 9.3e-11 41.5 0.3 1.5e-10 40.9 0.2 1.2 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_His PF13393.1 EPA06000.1 - 0.11 11.5 1.5 0.12 11.4 0.4 1.5 2 0 0 2 2 2 0 Histidyl-tRNA synthetase Fer4_7 PF12838.2 EPA06001.1 - 6.6e-10 39.2 2.2 0.00018 21.8 0.5 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.22 EPA06001.1 - 7.9e-10 37.9 11.9 5.4e-06 25.7 0.9 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.1 EPA06001.1 - 1.5e-08 34.4 0.4 0.0019 18.1 0.1 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.1 EPA06001.1 - 3e-08 33.8 4.8 9.4e-08 32.2 3.3 1.8 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.2 EPA06001.1 - 5.2e-07 29.2 12.5 0.00072 19.3 2.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.1 EPA06001.1 - 1.3e-06 29.0 4.5 0.0004 21.0 0.6 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_15 PF13459.1 EPA06001.1 - 1.6e-06 28.5 4.2 0.0045 17.5 0.2 2.5 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_10 PF13237.1 EPA06001.1 - 3.2e-06 26.8 20.0 7.9e-05 22.3 6.5 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.2 EPA06001.1 - 4.1e-06 26.3 11.7 0.0063 16.3 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_18 PF13746.1 EPA06001.1 - 1.8e-05 25.0 7.6 7.6e-05 23.0 3.7 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.1 EPA06001.1 - 2.4e-05 24.0 8.8 0.0025 17.6 6.3 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.2 EPA06001.1 - 4.5e-05 23.4 6.8 0.038 14.3 1.2 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.1 EPA06001.1 - 8.8e-05 22.8 6.4 0.031 14.6 0.1 2.5 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_17 PF13534.1 EPA06001.1 - 0.00026 21.2 5.3 0.0097 16.2 5.1 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_11 PF13247.1 EPA06001.1 - 0.0013 18.5 0.8 0.64 9.9 0.1 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.2 EPA06001.1 - 0.058 13.9 16.2 0.21 12.2 1.2 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain eIF-6 PF01912.13 EPA06002.1 - 2.8e-65 219.1 1.6 3.4e-65 218.8 1.1 1.1 1 0 0 1 1 1 1 eIF-6 family RIO1 PF01163.17 EPA06003.1 - 1.2e-52 178.0 0.0 1.6e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 EPA06003.1 - 0.0018 18.0 0.0 0.82 9.3 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family BBS2_Mid PF14783.1 EPA06003.1 - 0.036 13.8 0.0 0.074 12.8 0.0 1.4 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region Kdo PF06293.9 EPA06003.1 - 0.11 11.6 0.0 2.1 7.3 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family TP6A_N PF04406.9 EPA06004.1 - 2.5e-19 68.6 0.1 4.5e-19 67.8 0.1 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase SusD-like_2 PF12771.2 EPA06004.1 - 0.087 11.1 0.1 0.13 10.6 0.0 1.2 1 0 0 1 1 1 0 Starch-binding associating with outer membrane Toprim PF01751.17 EPA06004.1 - 0.098 12.6 0.3 0.2 11.6 0.0 1.8 2 0 0 2 2 2 0 Toprim domain DUF4018 PF13210.1 EPA06004.1 - 0.16 11.3 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4018) PIRT PF15099.1 EPA06005.1 - 0.00017 20.8 3.5 0.00057 19.1 0.3 2.3 1 1 1 2 2 2 1 Phosphoinositide-interacting protein family DUF2273 PF10031.4 EPA06005.1 - 0.042 13.4 1.6 0.042 13.4 1.1 4.4 6 0 0 6 6 6 0 Small integral membrane protein (DUF2273) Cupredoxin_1 PF13473.1 EPA06006.1 - 1.5e-10 40.9 0.0 1.7e-10 40.6 0.0 1.3 1 1 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.15 EPA06006.1 - 4.8e-09 36.3 0.0 9.2e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Connexin_CCC PF10582.4 EPA06006.1 - 3.4 7.5 5.3 18 5.2 1.0 2.2 2 0 0 2 2 2 0 Gap junction channel protein cysteine-rich domain Prenyltransf PF01255.14 EPA06007.1 - 6.4e-70 234.7 0.1 7e-70 234.6 0.1 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase GxGYxYP PF14323.1 EPA06007.1 - 0.021 13.5 0.0 0.027 13.1 0.0 1.1 1 0 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function Antiterm PF03589.8 EPA06008.1 - 0.001 19.1 0.6 0.0011 19.0 0.4 1.1 1 0 0 1 1 1 1 Antitermination protein zinc_ribbon_2 PF13240.1 EPA06008.1 - 0.0044 16.4 1.5 0.019 14.4 1.1 1.9 1 1 0 1 1 1 1 zinc-ribbon domain HypA PF01155.14 EPA06008.1 - 0.0088 15.7 0.7 0.0099 15.5 0.5 1.0 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family Auto_anti-p27 PF06677.7 EPA06008.1 - 0.029 14.1 2.1 0.11 12.2 0.1 2.2 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.2 EPA06008.1 - 0.032 14.0 3.4 0.059 13.1 2.4 1.4 1 1 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.1 EPA06008.1 - 0.039 13.1 3.4 0.11 11.7 0.4 2.1 2 0 0 2 2 2 0 zinc-ribbon domain GFA PF04828.9 EPA06008.1 - 0.05 13.5 2.5 0.26 11.2 1.9 1.7 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DUF2072 PF09845.4 EPA06008.1 - 0.12 12.3 1.4 0.18 11.6 1.0 1.4 1 1 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) zf-ISL3 PF14690.1 EPA06008.1 - 0.14 12.1 4.0 1.4 9.0 0.2 2.1 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-C4_Topoisom PF01396.14 EPA06008.1 - 0.15 11.6 1.8 0.23 11.0 0.1 2.0 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zinc_ribbon_5 PF13719.1 EPA06008.1 - 0.18 11.3 7.0 0.8 9.3 4.8 1.9 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA06008.1 - 0.23 11.1 7.2 1.1 9.0 5.0 1.9 1 1 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 EPA06008.1 - 0.33 10.9 3.6 2.9 7.9 2.5 2.0 1 1 0 1 1 1 0 Zinc ribbon domain DUF2082 PF09855.4 EPA06008.1 - 0.44 10.4 2.7 1.5 8.7 0.1 2.0 2 0 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-C3HC4_3 PF13920.1 EPA06008.1 - 0.59 9.8 3.9 3.1 7.5 2.7 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-tcix PF14952.1 EPA06008.1 - 0.62 9.4 4.2 0.17 11.2 0.5 1.8 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding ADK_lid PF05191.9 EPA06008.1 - 0.81 9.4 4.6 4.1 7.1 3.3 2.0 1 1 1 2 2 2 0 Adenylate kinase, active site lid DUF2387 PF09526.5 EPA06008.1 - 4.1 7.3 5.9 3.4 7.6 0.2 2.0 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) DUF1610 PF07754.6 EPA06008.1 - 4.6 7.4 6.3 0.89 9.7 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) zf-RanBP PF00641.13 EPA06008.1 - 6.1 6.0 6.1 16 4.6 0.7 2.2 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others CBFD_NFYB_HMF PF00808.18 EPA06009.1 - 4.9e-14 52.1 0.4 5.3e-14 52.0 0.3 1.0 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EPA06009.1 - 4.7e-09 36.2 0.2 5.4e-09 36.0 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 EPA06009.1 - 2.3e-05 24.4 0.0 2.6e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S Bromo_TP PF07524.8 EPA06009.1 - 0.00054 19.6 0.0 0.00063 19.4 0.0 1.1 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.10 EPA06009.1 - 0.0009 19.0 0.0 0.00092 18.9 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit TFIID_20kDa PF03847.8 EPA06009.1 - 0.0011 19.1 0.0 0.0014 18.8 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TAF PF02969.12 EPA06009.1 - 0.0037 17.1 0.5 0.0043 16.9 0.3 1.1 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TFIID-18kDa PF02269.11 EPA06009.1 - 0.024 14.4 0.0 0.026 14.3 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit DUF1931 PF09123.6 EPA06009.1 - 0.043 13.7 0.2 0.049 13.5 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1931) TFIIB PF00382.14 EPA06009.1 - 0.044 13.5 0.1 0.063 13.0 0.1 1.3 1 0 0 1 1 1 0 Transcription factor TFIIB repeat CENP-T PF15511.1 EPA06009.1 - 0.07 12.3 0.3 0.1 11.8 0.2 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T MR_MLE_N PF02746.11 EPA06009.1 - 0.074 13.0 0.1 0.082 12.9 0.1 1.1 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain TrmB PF01978.14 EPA06010.1 - 0.00021 20.9 0.0 0.00026 20.6 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB DUF424 PF04242.8 EPA06011.1 - 1.2e-22 79.7 0.5 1.4e-22 79.5 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF424) DUF1874 PF08960.5 EPA06011.1 - 0.036 13.7 0.3 0.084 12.6 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1874) DUF4284 PF14112.1 EPA06011.1 - 0.04 14.4 0.2 0.041 14.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4284) Adenylsucc_synt PF00709.16 EPA06012.1 - 7.7e-87 291.6 1.8 5.1e-41 140.7 0.0 3.0 1 1 2 3 3 3 3 Adenylosuccinate synthetase zinc_ribbon_4 PF13717.1 EPA06013.1 - 0.014 15.1 4.6 0.015 14.9 0.7 2.0 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_6 PF14599.1 EPA06013.1 - 0.014 15.1 0.8 0.019 14.7 0.6 1.2 1 0 0 1 1 1 0 Zinc-ribbon zinc_ribbon_5 PF13719.1 EPA06013.1 - 0.014 14.9 4.4 0.018 14.6 0.7 2.0 2 0 0 2 2 2 0 zinc-ribbon domain zinc-ribbons_6 PF07191.7 EPA06013.1 - 0.016 14.9 0.7 0.021 14.6 0.5 1.2 1 0 0 1 1 1 0 zinc-ribbons Ribosomal_S27e PF01667.12 EPA06013.1 - 0.038 13.5 4.0 0.071 12.6 2.8 1.4 1 1 0 1 1 1 0 Ribosomal protein S27 Ribosomal_L37ae PF01780.14 EPA06013.1 - 0.11 12.4 0.1 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 Ribosomal L37ae protein family HypA PF01155.14 EPA06013.1 - 0.11 12.1 0.4 0.13 11.9 0.3 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Zn_Tnp_IS1 PF03811.8 EPA06013.1 - 0.12 11.8 0.5 0.59 9.6 0.1 2.0 2 0 0 2 2 2 0 InsA N-terminal domain DUF329 PF03884.9 EPA06013.1 - 0.15 11.6 3.9 0.83 9.2 2.8 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF329) Prok-RING_1 PF14446.1 EPA06013.1 - 0.23 11.2 2.3 0.34 10.6 1.6 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Lar_restr_allev PF14354.1 EPA06013.1 - 0.23 11.7 2.0 0.93 9.8 1.4 1.9 1 1 0 1 1 1 0 Restriction alleviation protein Lar TFIIS_C PF01096.13 EPA06013.1 - 0.4 10.3 3.4 2.5 7.8 0.2 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-H2C2_2 PF13465.1 EPA06013.1 - 0.64 10.4 3.8 1.7 9.0 0.5 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zf-BED PF02892.10 EPA06013.1 - 0.87 9.4 3.5 2 8.2 0.0 2.1 1 1 1 2 2 2 0 BED zinc finger PhnA_Zn_Ribbon PF08274.7 EPA06013.1 - 1.8 8.4 7.2 4.7 7.0 0.4 2.4 1 1 1 2 2 2 0 PhnA Zinc-Ribbon eIF-5_eIF-2B PF01873.12 EPA06014.1 - 1.4e-27 95.8 0.0 1.6e-27 95.6 0.0 1.0 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Elf1 PF05129.8 EPA06014.1 - 0.067 12.8 0.4 0.12 12.0 0.3 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like DUF373 PF04123.8 EPA06015.1 - 8.9e-102 340.6 15.7 1.1e-101 340.3 10.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF373) DUF4229 PF14012.1 EPA06015.1 - 3.5 7.6 15.8 0.44 10.4 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4229) KH_1 PF00013.24 EPA06016.1 - 1.2e-14 53.7 10.5 2.1e-07 30.4 0.5 2.7 2 1 1 3 3 3 2 KH domain KH_3 PF13014.1 EPA06016.1 - 1.4e-06 27.8 12.1 0.0031 17.1 1.5 3.3 3 0 0 3 3 3 2 KH domain KH_2 PF07650.12 EPA06016.1 - 0.014 14.9 5.7 0.58 9.7 0.6 2.9 2 1 0 2 2 2 0 KH domain THUMP PF02926.12 EPA06017.1 - 1.8e-13 50.6 1.7 2.2e-13 50.3 1.2 1.1 1 0 0 1 1 1 1 THUMP domain RelB_N PF12910.2 EPA06017.1 - 0.1 11.9 0.0 0.41 10.0 0.0 2.0 1 0 0 1 1 1 0 Antitoxin of toxin-antitoxin stability system N-terminal HSBP1 PF06825.7 EPA06017.1 - 0.25 10.9 3.3 0.32 10.6 0.3 2.3 2 0 0 2 2 2 0 Heat shock factor binding protein 1 DUF1704 PF08014.6 EPA06018.1 - 0.026 13.5 0.0 0.049 12.6 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1704) GTP_EFTU_D3 PF03143.12 EPA06018.1 - 0.071 13.2 0.5 2.7 8.2 0.3 2.3 1 1 0 1 1 1 0 Elongation factor Tu C-terminal domain UPF0118 PF01594.11 EPA06018.1 - 0.14 11.1 0.5 0.26 10.2 0.1 1.5 1 1 1 2 2 2 0 Domain of unknown function DUF20 DUF1628 PF07790.6 EPA06018.1 - 0.14 12.9 0.4 0.28 11.9 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1628) WSN PF02206.13 EPA06018.1 - 0.22 11.2 1.5 6 6.6 0.3 2.6 3 0 0 3 3 3 0 Domain of unknown function OMPdecase PF00215.19 EPA06019.1 - 3.1e-28 98.7 0.0 3.6e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Ribosomal_S17e PF00833.13 EPA06020.1 - 1.6e-20 73.0 2.2 2.2e-20 72.6 1.5 1.2 1 0 0 1 1 1 1 Ribosomal S17 DUF4201 PF13870.1 EPA06020.1 - 0.004 16.6 2.5 0.0048 16.3 1.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) RSD-2 PF07547.8 EPA06021.1 - 0.11 12.6 0.6 0.12 12.5 0.4 1.1 1 0 0 1 1 1 0 RSD-2 N-terminal domain Annexin PF00191.15 EPA06022.1 - 0.00098 18.9 0.0 0.0019 18.0 0.0 1.5 1 0 0 1 1 1 1 Annexin CofC PF01983.11 EPA06022.1 - 0.044 12.7 0.5 0.091 11.7 0.1 1.7 2 0 0 2 2 2 0 Guanylyl transferase CofC like Glyco_transf_54 PF04666.8 EPA06022.1 - 0.074 11.7 0.5 0.12 11.1 0.3 1.4 1 1 0 1 1 1 0 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region CaM_binding PF07839.6 EPA06022.1 - 0.11 12.6 0.8 0.21 11.8 0.2 1.6 2 0 0 2 2 2 0 Plant calmodulin-binding domain Topo-VIb_trans PF09239.6 EPA06023.1 - 7.4e-58 194.6 0.0 1.2e-57 193.9 0.0 1.3 1 0 0 1 1 1 1 Topoisomerase VI B subunit, transducer HATPase_c_3 PF13589.1 EPA06023.1 - 2e-07 30.7 0.0 4.2e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 EPA06023.1 - 5.2e-07 29.3 0.0 1.1e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HTH_45 PF14947.1 EPA06024.1 - 1.3e-12 47.2 0.2 1.8e-12 46.9 0.1 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix MarR_2 PF12802.2 EPA06024.1 - 2.5e-07 30.2 0.0 3.6e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_IclR PF09339.5 EPA06024.1 - 5.6e-05 22.6 0.0 7.2e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_24 PF13412.1 EPA06024.1 - 0.0001 21.6 0.2 0.0002 20.6 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.14 EPA06024.1 - 0.00028 20.5 0.0 0.00039 20.0 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.17 EPA06024.1 - 0.00029 20.4 0.0 0.00038 20.1 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.1 EPA06024.1 - 0.00085 19.5 0.0 0.001 19.3 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain RPA_C PF08784.6 EPA06024.1 - 0.0014 19.0 0.0 0.0021 18.4 0.0 1.2 1 0 0 1 1 1 1 Replication protein A C terminal RP-C PF03428.8 EPA06024.1 - 0.0015 18.0 0.1 0.0017 17.8 0.0 1.1 1 0 0 1 1 1 1 Replication protein C N-terminal domain Mrr_N PF14338.1 EPA06024.1 - 0.0015 18.5 0.0 0.0021 18.1 0.0 1.4 1 1 0 1 1 1 1 Mrr N-terminal domain HTH_34 PF13601.1 EPA06024.1 - 0.0037 17.2 0.1 0.0057 16.6 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain DUF4364 PF14277.1 EPA06024.1 - 0.0048 16.5 0.1 0.007 15.9 0.0 1.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4364) RQC PF09382.5 EPA06024.1 - 0.0067 16.1 0.1 0.0075 15.9 0.0 1.1 1 0 0 1 1 1 1 RQC domain FeoC PF09012.5 EPA06024.1 - 0.0069 16.0 0.0 0.0079 15.8 0.0 1.1 1 0 0 1 1 1 1 FeoC like transcriptional regulator RNA_pol_Rpc34 PF05158.7 EPA06024.1 - 0.0095 15.1 0.1 0.0098 15.1 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit HTH_20 PF12840.2 EPA06024.1 - 0.016 15.0 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain Rrf2 PF02082.15 EPA06024.1 - 0.016 15.3 0.1 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator DUF2250 PF10007.4 EPA06024.1 - 0.018 14.9 0.1 0.039 13.8 0.1 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) HTH_Crp_2 PF13545.1 EPA06024.1 - 0.027 14.2 0.2 0.08 12.7 0.1 1.8 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_5 PF01022.15 EPA06024.1 - 0.051 13.2 0.1 0.093 12.4 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family PadR PF03551.9 EPA06024.1 - 0.051 13.3 0.0 0.066 12.9 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family Ftsk_gamma PF09397.5 EPA06024.1 - 0.066 12.9 0.1 0.082 12.6 0.0 1.2 1 0 0 1 1 1 0 Ftsk gamma domain Linker_histone PF00538.14 EPA06024.1 - 0.07 13.2 0.0 0.14 12.2 0.0 1.7 1 1 0 1 1 1 0 linker histone H1 and H5 family CENP-B_N PF04218.8 EPA06024.1 - 0.13 11.7 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Mga PF05043.8 EPA06024.1 - 0.14 12.4 1.0 0.63 10.3 0.2 2.1 1 1 1 2 2 2 0 Mga helix-turn-helix domain NUDIX PF00293.23 EPA06025.1 - 1.1e-17 63.9 0.1 1.2e-17 63.7 0.1 1.0 1 0 0 1 1 1 1 NUDIX domain DBC1 PF14443.1 EPA06025.1 - 0.059 12.8 0.1 0.079 12.4 0.0 1.2 1 0 0 1 1 1 0 DBC1 DUF1912 PF08930.5 EPA06025.1 - 0.8 9.8 3.4 11 6.1 0.5 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1912) TatD_DNase PF01026.16 EPA06027.1 - 1.1e-45 155.8 0.0 1.2e-45 155.7 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Iron_traffic PF04362.9 EPA06028.1 - 4.8e-09 35.5 0.4 6.3e-09 35.1 0.3 1.4 1 1 0 1 1 1 1 Bacterial Fe(2+) trafficking zinc_ribbon_2 PF13240.1 EPA06028.1 - 0.0087 15.5 0.2 0.018 14.5 0.1 1.5 1 1 0 1 1 1 1 zinc-ribbon domain GATA PF00320.22 EPA06028.1 - 0.11 11.8 0.2 0.11 11.8 0.1 1.9 2 0 0 2 2 2 0 GATA zinc finger DIPSY PF11763.3 EPA06029.1 - 0.052 13.3 0.0 0.061 13.1 0.0 1.2 1 0 0 1 1 1 0 Cell-wall adhesin ligand-binding C-terminal DUF3169 PF11368.3 EPA06029.1 - 0.076 12.2 3.0 0.1 11.8 1.5 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) GvpH PF05455.6 EPA06029.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.4 1 1 1 2 2 2 0 GvpH BaxI_1 PF12811.2 EPA06031.1 - 0.013 14.7 0.7 0.014 14.5 0.5 1.1 1 0 0 1 1 1 0 Bax inhibitor 1 like ThiS PF02597.15 EPA06032.1 - 3.3e-07 30.6 0.1 9.5e-07 29.1 0.0 1.8 2 0 0 2 2 2 1 ThiS family CGI-121 PF08617.5 EPA06032.1 - 1.6e-06 27.8 5.2 3.8e-06 26.6 3.4 1.7 2 0 0 2 2 2 1 Kinase binding protein CGI-121 Urm1 PF09138.6 EPA06032.1 - 0.0064 16.5 2.3 0.011 15.8 0.3 2.5 2 2 1 3 3 3 1 Urm1 (Ubiquitin related modifier) Cdc6_C PF09079.6 EPA06033.1 - 1e-06 28.3 0.2 1.2e-06 28.1 0.2 1.1 1 0 0 1 1 1 1 CDC6, C terminal DNA_pol_E_B PF04042.11 EPA06034.1 - 6.9e-06 25.4 0.0 1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Metallophos_2 PF12850.2 EPA06034.1 - 0.0019 18.0 0.0 0.0022 17.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DNA_pol_E_B PF04042.11 EPA06035.1 - 6.9e-06 25.4 0.0 1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Metallophos_2 PF12850.2 EPA06035.1 - 0.0019 18.0 0.0 0.0022 17.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Cdc6_C PF09079.6 EPA06036.1 - 3e-11 42.8 0.8 3.4e-11 42.7 0.5 1.0 1 0 0 1 1 1 1 CDC6, C terminal DUF512 PF04459.7 EPA06036.1 - 0.025 13.6 0.2 0.028 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF512) Abi PF02517.11 EPA06037.1 - 0.0082 16.2 3.2 0.0082 16.2 2.2 3.0 2 1 1 3 3 3 1 CAAX protease self-immunity DUF165 PF02592.10 EPA06037.1 - 0.77 9.9 6.5 0.12 12.5 2.0 1.5 2 0 0 2 2 2 0 Uncharacterized ACR, YhhQ family COG1738 Thioredoxin_4 PF13462.1 EPA06038.1 - 2.2e-41 141.5 0.2 4e-41 140.7 0.0 1.5 2 0 0 2 2 2 1 Thioredoxin DSBA PF01323.15 EPA06038.1 - 5e-20 71.8 0.4 5.1e-18 65.3 0.3 2.2 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.1 EPA06038.1 - 3e-09 37.0 0.0 1.3e-08 35.0 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Phi-29_GP16_7 PF06720.6 EPA06038.1 - 0.076 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 Thioredoxin_5 PF13743.1 EPA06038.1 - 0.078 12.5 0.0 0.19 11.2 0.0 1.5 1 1 0 1 1 1 0 Thioredoxin Response_reg PF00072.19 EPA06039.1 - 1.1e-10 41.4 0.0 2e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain zf-Di19 PF05605.7 EPA06039.1 - 0.00029 20.9 2.6 0.00029 20.9 1.8 2.2 1 1 1 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-FPG_IleRS PF06827.9 EPA06039.1 - 0.0068 16.0 2.7 0.23 11.1 0.1 3.3 3 0 0 3 3 3 1 Zinc finger found in FPG and IleRS FeoC PF09012.5 EPA06039.1 - 0.021 14.5 1.5 0.082 12.6 1.0 2.0 1 0 0 1 1 1 0 FeoC like transcriptional regulator Sgf11 PF08209.6 EPA06039.1 - 0.037 13.3 8.2 0.32 10.3 0.1 3.6 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) DZR PF12773.2 EPA06039.1 - 0.48 10.2 18.8 2 8.2 2.1 3.3 1 1 2 3 3 3 0 Double zinc ribbon zf-C3HC4_3 PF13920.1 EPA06039.1 - 0.52 10.0 14.2 5 6.8 0.1 3.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Spt4 PF06093.8 EPA06039.1 - 1.2 9.0 14.4 0.22 11.4 0.7 3.3 3 0 0 3 3 3 0 Spt4/RpoE2 zinc finger zinc-ribbons_6 PF07191.7 EPA06039.1 - 2.2 8.1 18.2 13 5.6 7.2 3.2 1 1 2 3 3 3 0 zinc-ribbons Zn_Tnp_IS1595 PF12760.2 EPA06039.1 - 3.2 7.6 14.5 0.34 10.7 0.7 3.8 3 1 0 3 3 3 0 Transposase zinc-ribbon domain Radical_SAM PF04055.16 EPA06043.1 - 1.1e-05 25.7 0.1 4.3e-05 23.7 0.1 2.3 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.1 EPA06043.1 - 4.8e-05 23.3 0.0 0.00017 21.6 0.0 1.9 1 1 1 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 EPA06043.1 - 0.00068 19.7 0.2 0.0019 18.3 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S single cluster domain Peptidase_S8 PF00082.17 EPA06045.1 - 2.7e-58 197.3 14.1 3.5e-58 196.9 9.8 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EPA06045.1 - 4.3e-10 40.0 0.0 7.8e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 TPP_enzyme_N PF02776.13 EPA06046.1 - 8.9e-56 188.0 0.0 7.5e-54 181.7 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 EPA06046.1 - 2.8e-39 134.1 0.0 8.5e-39 132.5 0.0 1.9 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 EPA06046.1 - 3.6e-28 98.0 0.0 9e-28 96.7 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain CO_dh PF02552.11 EPA06046.1 - 0.012 15.2 0.1 0.029 13.9 0.1 1.7 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit DUF362 PF04015.7 EPA06046.1 - 0.068 12.6 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF362) PvlArgDC PF01862.11 EPA06049.1 - 3.1e-61 205.7 0.0 3.5e-61 205.6 0.0 1.0 1 0 0 1 1 1 1 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) DUF2353 PF09789.4 EPA06050.1 - 0.016 14.4 9.9 0.018 14.3 6.9 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) COPIIcoated_ERV PF07970.7 EPA06050.1 - 0.13 11.8 2.7 0.15 11.6 1.9 1.1 1 0 0 1 1 1 0 Endoplasmic reticulum vesicle transporter Tox-ART-HYD1 PF15633.1 EPA06050.1 - 0.36 11.6 5.2 0.47 11.2 3.6 1.2 1 0 0 1 1 1 0 HYD1 signature containing ADP-ribosyltransferase Bromodomain PF00439.20 EPA06050.1 - 0.66 9.9 4.3 10 6.1 3.0 2.1 1 1 0 1 1 1 0 Bromodomain IncA PF04156.9 EPA06050.1 - 3.6 7.1 12.4 1e+02 2.4 8.6 2.2 1 1 0 1 1 1 0 IncA protein AsnC_trans_reg PF01037.16 EPA06051.1 - 1.6e-08 34.1 0.1 1.7e-08 34.0 0.1 1.0 1 0 0 1 1 1 1 AsnC family GYD PF08734.6 EPA06051.1 - 0.00032 20.3 0.1 0.00034 20.2 0.0 1.1 1 0 0 1 1 1 1 GYD domain DHO_dh PF01180.16 EPA06051.1 - 0.097 11.6 0.5 0.12 11.3 0.3 1.0 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Pyrophosphatase PF00719.14 EPA06052.1 - 2.7e-58 195.8 0.1 3.2e-58 195.6 0.1 1.0 1 0 0 1 1 1 1 Inorganic pyrophosphatase Response_reg PF00072.19 EPA06053.1 - 3.7e-11 42.9 0.0 4.3e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain LAGLIDADG_3 PF14528.1 EPA06053.1 - 0.032 14.4 0.3 0.15 12.3 0.1 2.0 2 1 0 2 2 2 0 LAGLIDADG-like domain NLBH PF05211.7 EPA06053.1 - 0.17 11.0 1.5 0.19 10.9 1.0 1.1 1 0 0 1 1 1 0 Neuraminyllactose-binding hemagglutinin precursor (NLBH) Coiled-coil_56 PF09813.4 EPA06054.1 - 0.027 14.4 0.1 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 56 FA_desaturase PF00487.19 EPA06054.1 - 0.29 10.5 5.4 0.42 10.0 3.8 1.3 1 0 0 1 1 1 0 Fatty acid desaturase CBS PF00571.23 EPA06055.1 - 9.4e-43 143.7 6.3 1.2e-10 41.0 0.0 4.3 4 0 0 4 4 4 4 CBS domain Staphostatin_A PF09022.5 EPA06055.1 - 0.11 12.3 0.1 0.11 12.3 0.1 2.4 2 0 0 2 2 2 0 Staphostatin A Usp PF00582.21 EPA06056.1 - 1.5e-12 47.8 0.0 1.6e-12 47.7 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family Amidohydro_2 PF04909.9 EPA06057.1 - 3.2e-35 122.0 0.0 3.5e-35 121.8 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase Trp_syntA PF00290.15 EPA06057.1 - 0.014 13.9 0.0 0.029 12.8 0.0 1.6 1 0 0 1 1 1 0 Tryptophan synthase alpha chain YtzH PF14165.1 EPA06057.1 - 0.034 14.3 0.0 0.063 13.5 0.0 1.5 1 0 0 1 1 1 0 YtzH-like protein DEAD PF00270.24 EPA06058.1 - 1.7e-48 164.2 0.2 6.2e-46 155.9 0.0 2.2 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 EPA06058.1 - 1e-25 89.3 0.0 1.2e-24 85.9 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EPA06058.1 - 0.0034 16.2 0.0 0.0053 15.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 EPA06058.1 - 0.011 15.6 0.2 0.019 14.8 0.1 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit CMS1 PF14617.1 EPA06058.1 - 0.011 14.8 0.2 0.045 12.8 0.1 1.9 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AAA_30 PF13604.1 EPA06058.1 - 0.015 14.9 0.3 0.035 13.6 0.2 1.6 1 1 0 1 1 1 0 AAA domain His_Phos_1 PF00300.17 EPA06058.1 - 0.015 15.4 0.0 0.027 14.5 0.0 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) Helicase_C_2 PF13307.1 EPA06058.1 - 0.029 14.3 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 Helicase C-terminal domain Flavi_DEAD PF07652.9 EPA06058.1 - 0.096 12.4 0.1 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain DUF2232 PF09991.4 EPA06059.1 - 0.022 13.7 0.2 0.022 13.7 0.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Tetraspannin PF00335.15 EPA06059.1 - 0.059 12.6 0.3 0.06 12.6 0.2 1.1 1 0 0 1 1 1 0 Tetraspanin family PgaD PF13994.1 EPA06059.1 - 0.084 12.3 0.0 0.084 12.3 0.0 1.1 1 0 0 1 1 1 0 PgaD-like protein Brevenin PF03032.10 EPA06059.1 - 5 7.0 5.2 0.88 9.4 1.0 1.6 2 0 0 2 2 2 0 Brevenin/esculentin/gaegurin/rugosin family SHOCT PF09851.4 EPA06060.1 - 3.2e-08 32.7 5.2 7.4e-08 31.6 3.6 1.7 1 0 0 1 1 1 1 Short C-terminal domain GvpG PF05120.7 EPA06060.1 - 0.021 14.5 0.2 0.031 14.0 0.1 1.3 1 0 0 1 1 1 0 Gas vesicle protein G Ribosomal_L18p PF00861.17 EPA06060.1 - 0.048 13.8 0.4 0.06 13.5 0.2 1.3 1 0 0 1 1 1 0 Ribosomal L18p/L5e family DMAP_binding PF06464.6 EPA06060.1 - 0.91 10.1 3.5 0.67 10.5 1.2 1.7 1 1 0 1 1 1 0 DMAP1-binding Domain Peptidase_M3 PF01432.15 EPA06062.1 - 7e-46 157.2 0.7 4.3e-45 154.5 0.5 2.1 1 1 0 1 1 1 1 Peptidase family M3 Peptidase_M3_N PF08439.5 EPA06062.1 - 1.3e-07 31.5 0.2 1.3e-07 31.5 0.2 3.5 5 0 0 5 5 5 1 Oligopeptidase F DUF955 PF06114.8 EPA06062.1 - 0.00096 18.8 0.1 0.0028 17.3 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF955) DUF3198 PF11433.3 EPA06062.1 - 0.0048 16.7 0.8 0.23 11.3 0.1 2.8 1 1 1 2 2 2 1 Protein of unknown function (DUF3198) Peptidase_MA_2 PF13485.1 EPA06062.1 - 0.012 15.6 0.0 0.035 14.1 0.0 1.8 1 0 0 1 1 1 0 Peptidase MA superfamily Zn_peptidase_2 PF04298.7 EPA06062.1 - 0.13 11.5 0.2 0.3 10.3 0.1 1.5 1 1 0 1 1 1 0 Putative neutral zinc metallopeptidase FG-GAP_2 PF14312.1 EPA06062.1 - 0.15 12.0 0.1 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 FG-GAP repeat DUF2392 PF10288.4 EPA06062.1 - 0.16 12.3 2.4 1.1 9.5 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2392) Syntaxin PF00804.20 EPA06062.1 - 1.5 8.9 10.4 0.74 10.0 0.3 3.7 3 1 2 5 5 5 0 Syntaxin Acyl_transf_3 PF01757.17 EPA06063.1 - 0.11 11.2 24.3 0.11 11.3 9.9 2.1 1 1 1 2 2 2 0 Acyltransferase family Cytochrome-c551 PF10643.4 EPA06063.1 - 0.65 9.2 4.5 0.93 8.7 3.1 1.3 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 DUF3429 PF11911.3 EPA06063.1 - 0.82 9.6 8.8 2.4 8.1 1.4 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3429) DUF1700 PF08006.6 EPA06063.1 - 3.2 7.0 12.3 0.37 10.0 5.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) YoqO PF14037.1 EPA06063.1 - 5 7.2 14.7 0.7 10.0 3.3 2.9 2 1 1 3 3 3 0 YoqO-like protein DUF2324 PF10086.4 EPA06063.1 - 9.4 5.3 8.9 0.41 9.8 0.8 2.2 2 1 0 2 2 2 0 Putative membrane peptidase family (DUF2324) DUF1059 PF06348.6 EPA06065.1 - 7e-08 32.1 0.2 7e-08 32.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) YqzH PF14164.1 EPA06065.1 - 0.11 12.4 0.1 0.16 11.8 0.0 1.3 1 1 0 1 1 1 0 YqzH-like protein MS_channel PF00924.13 EPA06066.1 - 1.4e-28 99.6 0.0 3.2e-28 98.4 0.0 1.6 1 0 0 1 1 1 1 Mechanosensitive ion channel DUF1774 PF08611.5 EPA06066.1 - 0.068 13.3 1.2 0.2 11.8 0.9 1.9 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1774) LIM PF00412.17 EPA06067.1 - 0.02 14.9 3.1 0.028 14.5 2.1 1.2 1 0 0 1 1 1 0 LIM domain XPA_N PF01286.13 EPA06067.1 - 0.048 13.3 5.0 0.2 11.3 3.5 1.9 1 1 0 1 1 1 0 XPA protein N-terminal DZR PF12773.2 EPA06067.1 - 0.053 13.3 0.7 0.064 13.0 0.5 1.2 1 0 0 1 1 1 0 Double zinc ribbon zf-UBR PF02207.15 EPA06067.1 - 0.25 11.1 2.6 0.42 10.3 1.8 1.4 1 1 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) zinc_ribbon_6 PF14599.1 EPA06068.1 - 0.0017 18.1 1.5 0.0034 17.1 1.0 1.5 1 1 0 1 1 1 1 Zinc-ribbon zinc_ribbon_2 PF13240.1 EPA06068.1 - 0.026 14.0 1.5 4.2 6.9 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain ArfGap PF01412.13 EPA06068.1 - 0.09 12.5 0.2 0.1 12.3 0.2 1.1 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf GCC2_GCC3 PF07699.8 EPA06068.1 - 0.16 11.6 3.2 0.24 11.0 2.2 1.4 1 1 0 1 1 1 0 GCC2 and GCC3 OrfB_Zn_ribbon PF07282.6 EPA06068.1 - 0.19 11.3 2.4 0.23 11.1 1.7 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-C4_ClpX PF06689.8 EPA06068.1 - 0.83 9.2 3.8 1.2 8.6 2.6 1.3 1 0 0 1 1 1 0 ClpX C4-type zinc finger zf-ribbon_3 PF13248.1 EPA06068.1 - 1.7 7.9 6.7 4 6.7 4.7 1.7 1 1 0 1 1 1 0 zinc-ribbon domain zf-HYPF PF07503.7 EPA06068.1 - 2.4 7.6 6.6 6.9 6.1 0.6 2.2 2 0 0 2 2 2 0 HypF finger FtsH_ext PF06480.10 EPA06069.1 - 1.1 9.4 5.9 1.2 9.2 1.3 2.4 1 1 1 2 2 2 0 FtsH Extracellular Acetyltransf_9 PF13527.1 EPA06070.1 - 1.9e-07 30.9 0.0 0.00097 19.0 0.0 2.2 1 1 1 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EPA06070.1 - 2.8e-06 27.2 0.0 4.6e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EPA06070.1 - 0.0088 16.1 0.0 0.052 13.7 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EPA06070.1 - 0.017 15.2 0.0 0.099 12.7 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain ADH_zinc_N PF00107.21 EPA06072.1 - 0.04 13.4 0.0 0.06 12.8 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DUF4407 PF14362.1 EPA06073.1 - 3.1 6.6 6.1 9.2 5.1 4.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Corona_nucleoca PF00937.13 EPA06077.1 - 0.0029 16.6 5.0 0.0032 16.4 3.5 1.0 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein Host_attach PF10116.4 EPA06077.1 - 0.07 13.3 3.1 0.066 13.4 2.1 1.1 1 0 0 1 1 1 0 Protein required for attachment to host cells DUF4106 PF13388.1 EPA06077.1 - 0.42 9.5 11.0 0.42 9.5 7.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) SOXp PF12336.3 EPA06077.1 - 0.55 10.8 5.9 0.69 10.5 4.1 1.2 1 0 0 1 1 1 0 SOX transcription factor DUF4230 PF14014.1 EPA06077.1 - 0.71 9.7 5.2 0.73 9.6 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4230) TrbI PF03743.9 EPA06077.1 - 4.2 6.8 15.5 6.3 6.2 10.7 1.4 1 1 0 1 1 1 0 Bacterial conjugation TrbI-like protein Response_reg PF00072.19 EPA06078.1 - 8.6e-23 80.4 2.6 1.6e-22 79.5 1.0 2.2 2 0 0 2 2 2 1 Response regulator receiver domain TrmB PF01978.14 EPA06078.1 - 1.8e-14 53.1 0.1 5.7e-14 51.5 0.0 1.9 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.3 EPA06078.1 - 6.6e-06 25.2 1.1 1.2e-05 24.4 0.4 1.6 2 0 0 2 2 2 1 Archaeal transcriptional regulator TrmB Glutaredoxin PF00462.19 EPA06078.1 - 0.049 13.6 0.0 0.37 10.8 0.0 2.6 2 0 0 2 2 2 0 Glutaredoxin V-ATPase_H_C PF11698.3 EPA06078.1 - 3.7 7.4 6.7 8.9 6.2 2.6 2.8 2 1 0 2 2 2 0 V-ATPase subunit H HATPase_c PF02518.21 EPA06079.1 - 3.5e-21 75.0 0.0 6.5e-21 74.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.20 EPA06079.1 - 2.2e-11 43.7 0.0 8.2e-11 41.9 0.0 2.0 2 0 0 2 2 2 1 HAMP domain HATPase_c_5 PF14501.1 EPA06079.1 - 6.3e-11 41.8 0.5 2.6e-09 36.6 0.0 3.0 2 1 1 3 3 3 1 GHKL domain HisKA PF00512.20 EPA06079.1 - 8.8e-09 35.2 1.3 1.6e-08 34.4 0.1 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain 4HB_MCP_1 PF12729.2 EPA06079.1 - 4.5e-05 22.8 9.6 4.5e-05 22.8 6.7 3.3 2 2 0 2 2 2 1 Four helix bundle sensory module for signal transduction HATPase_c_3 PF13589.1 EPA06079.1 - 0.077 12.6 1.4 0.15 11.7 0.3 2.1 2 1 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Syntaxin-6_N PF09177.6 EPA06079.1 - 0.17 12.2 4.4 1.6 9.1 0.0 3.8 4 0 0 4 4 4 0 Syntaxin 6, N-terminal DUF2392 PF10288.4 EPA06080.1 - 0.12 12.7 2.0 0.77 10.1 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2392) DUF3927 PF13064.1 EPA06082.1 - 0.088 12.3 0.1 0.12 11.8 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3927) DUF4044 PF13253.1 EPA06082.1 - 1.1 8.4 3.2 1.6 7.9 2.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) HisG PF01634.13 EPA06083.1 - 3.5e-38 130.7 0.0 4.3e-38 130.4 0.0 1.1 1 0 0 1 1 1 1 ATP phosphoribosyltransferase PINIT PF14324.1 EPA06083.1 - 0.012 15.6 0.0 5.7 7.0 0.0 2.6 2 0 0 2 2 2 0 PINIT domain Histidinol_dh PF00815.15 EPA06084.1 - 3e-106 355.5 0.2 3.3e-106 355.3 0.2 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase Alpha-L-AF_C PF06964.7 EPA06084.1 - 0.08 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Alpha-L-arabinofuranosidase C-terminus HAD_2 PF13419.1 EPA06085.1 - 0.022 14.9 0.1 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EPA06085.1 - 0.096 13.0 0.1 0.25 11.7 0.1 1.9 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Histidinol_dh PF00815.15 EPA06086.1 - 6.1e-10 38.3 0.6 6.8e-10 38.1 0.4 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase ICAT PF06384.6 EPA06086.1 - 0.031 14.0 0.8 0.037 13.7 0.5 1.4 1 0 0 1 1 1 0 Beta-catenin-interacting protein ICAT ArsA_ATPase PF02374.10 EPA06086.1 - 0.031 13.3 0.5 0.033 13.2 0.3 1.2 1 0 0 1 1 1 0 Anion-transporting ATPase SmpB PF01668.13 EPA06086.1 - 0.084 12.6 0.2 0.13 12.1 0.2 1.4 1 0 0 1 1 1 0 SmpB protein DPM3 PF08285.6 EPA06087.1 - 0.094 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Aminotran_1_2 PF00155.16 EPA06088.1 - 6.6e-45 153.6 0.0 7.8e-45 153.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EPA06088.1 - 0.0054 15.5 0.0 0.17 10.6 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V HD_4 PF13328.1 EPA06089.1 - 7.1e-24 84.2 0.1 8.7e-24 83.9 0.1 1.1 1 0 0 1 1 1 1 HD domain DUF4113 PF13438.1 EPA06089.1 - 0.12 11.9 0.0 0.48 10.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4113) HD PF01966.17 EPA06089.1 - 0.13 12.3 0.1 0.25 11.3 0.0 1.7 1 1 0 1 1 1 0 HD domain DUF4145 PF13643.1 EPA06089.1 - 8.6 6.2 9.3 45 3.9 5.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4145) Y_Y_Y PF07495.8 EPA06091.1 - 0.074 12.8 0.1 0.1 12.3 0.0 1.7 1 1 0 1 1 1 0 Y_Y_Y domain Vir_act_alpha_C PF10400.4 EPA06092.1 - 0.12 12.7 0.2 0.12 12.7 0.1 1.1 1 0 0 1 1 1 0 Virulence activator alpha C-term IATP PF04568.7 EPA06092.1 - 0.17 11.8 2.1 0.17 11.9 1.4 1.1 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP MAF_flag10 PF01973.13 EPA06093.1 - 8e-30 103.5 0.3 1.1e-29 103.1 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF115 TPK_catalytic PF04263.11 EPA06093.1 - 0.031 13.8 0.3 3 7.4 0.1 2.3 1 1 0 2 2 2 0 Thiamin pyrophosphokinase, catalytic domain Anticodon_1 PF08264.8 EPA06094.1 - 7e-18 64.8 0.2 1.2e-17 64.1 0.2 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA HEPPP_synt_1 PF07307.6 EPA06094.1 - 0.022 14.2 0.0 0.061 12.7 0.0 1.7 1 1 1 2 2 2 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 COQ9 PF08511.6 EPA06094.1 - 0.088 12.3 0.0 0.6 9.6 0.0 2.3 3 0 0 3 3 3 0 COQ9 DUF4320 PF14208.1 EPA06094.1 - 0.11 12.4 0.3 0.25 11.3 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) RibD_C PF01872.12 EPA06095.1 - 4.6e-18 65.5 0.4 1.4e-15 57.4 0.3 2.1 1 1 0 1 1 1 1 RibD C-terminal domain DHFR_1 PF00186.14 EPA06095.1 - 9.9e-10 38.2 0.0 1e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase CAP PF00188.21 EPA06096.1 - 6.7e-20 71.8 3.3 1.5e-19 70.6 1.1 2.3 2 1 0 2 2 2 1 Cysteine-rich secretory protein family FliD_C PF07195.7 EPA06096.1 - 0.0044 16.3 1.4 0.009 15.3 1.0 1.4 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 C-terminus FUN14 PF04930.10 EPA06096.1 - 0.12 12.6 1.2 1.2 9.5 0.2 2.3 2 0 0 2 2 2 0 FUN14 family DUF2232 PF09991.4 EPA06096.1 - 0.17 10.8 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) PG_binding_4 PF12229.3 EPA06096.1 - 0.29 11.3 7.6 3.1 8.0 1.2 2.4 1 1 1 2 2 2 0 Putative peptidoglycan binding domain DUF972 PF06156.8 EPA06096.1 - 3 8.2 10.3 7.9 6.8 0.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF972) DUF45 PF01863.12 EPA06097.1 - 7.3e-37 127.1 4.6 8.1e-37 127.0 3.2 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF45 WLM PF08325.5 EPA06097.1 - 2.4e-06 27.5 1.2 4.6e-06 26.6 0.8 1.5 1 0 0 1 1 1 1 WLM domain SprT-like PF10263.4 EPA06097.1 - 0.00032 20.3 1.3 0.00063 19.4 0.9 1.5 1 1 0 1 1 1 1 SprT-like family HTH_6 PF01418.12 EPA06097.1 - 0.033 13.9 0.3 0.25 11.0 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family DUF2342 PF10103.4 EPA06097.1 - 0.096 11.6 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2342) DUF4208 PF13907.1 EPA06097.1 - 0.12 12.5 1.7 0.27 11.4 1.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4208) WavE PF07507.6 EPA06097.1 - 0.21 10.4 4.5 0.25 10.2 3.1 1.2 1 1 0 1 1 1 0 WavE lipopolysaccharide synthesis Peptidase_M57 PF12388.3 EPA06098.1 - 0.00011 21.5 0.5 0.00019 20.8 0.3 1.4 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Reprolysin_5 PF13688.1 EPA06098.1 - 0.0071 16.2 0.4 0.016 15.1 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Porph_ging PF09697.5 EPA06098.1 - 0.019 15.0 0.2 0.019 15.0 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) Peptidase_M43 PF05572.8 EPA06098.1 - 0.046 13.3 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Trypan_PARP PF05887.6 EPA06099.1 - 0.019 14.7 11.8 0.027 14.2 8.2 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pex14_N PF04695.8 EPA06099.1 - 0.14 12.1 0.2 0.28 11.2 0.1 1.5 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF72 PF01904.13 EPA06101.1 - 1.9e-48 165.2 0.0 2.1e-48 165.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF72 HSDR_N_2 PF13588.1 EPA06102.1 - 0.00024 20.8 0.1 0.00039 20.1 0.1 1.5 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) DUF234 PF03008.9 EPA06102.1 - 0.022 14.8 1.7 0.028 14.5 0.5 1.7 2 0 0 2 2 2 0 Archaea bacterial proteins of unknown function DUF4143 PF13635.1 EPA06102.1 - 0.11 12.7 0.3 0.19 11.9 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4143) TPR_16 PF13432.1 EPA06103.1 - 0.00022 21.7 0.0 0.00034 21.1 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.1 EPA06103.1 - 0.00082 18.9 0.7 0.0068 16.1 0.2 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 EPA06103.1 - 0.0011 18.5 0.3 0.003 17.1 0.2 1.7 1 0 0 1 1 1 1 TPR repeat TPR_6 PF13174.1 EPA06103.1 - 0.0053 17.1 0.1 6.1 7.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 EPA06103.1 - 0.0057 16.5 0.7 0.2 11.5 0.1 1.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 EPA06103.1 - 0.0077 16.3 0.1 0.12 12.6 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 EPA06103.1 - 0.013 15.3 0.2 0.18 11.7 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyco_hydro_63 PF03200.11 EPA06103.1 - 0.032 12.0 0.7 0.037 11.8 0.5 1.0 1 0 0 1 1 1 0 Mannosyl oligosaccharide glucosidase TPR_14 PF13428.1 EPA06103.1 - 0.042 14.4 0.0 0.48 11.2 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF3808 PF10300.4 EPA06103.1 - 0.052 12.1 0.1 0.069 11.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) 2_5_RNA_ligase2 PF13563.1 EPA06104.1 - 5.1e-16 58.7 0.0 8.7e-16 58.0 0.0 1.3 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily AKAP7_NLS PF10469.4 EPA06104.1 - 0.0012 18.5 0.1 0.0018 17.9 0.1 1.3 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain IMPDH PF00478.20 EPA06105.1 - 3.4e-93 312.3 9.4 3.8e-93 312.1 6.5 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 EPA06105.1 - 4.1e-07 29.1 4.7 4.6e-07 28.9 2.6 1.5 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 EPA06105.1 - 5.3e-07 29.1 1.2 0.0046 16.2 0.1 2.3 1 1 1 2 2 2 2 Histidine biosynthesis protein NMO PF03060.10 EPA06105.1 - 4.5e-05 22.7 7.0 9.2e-05 21.7 4.9 1.5 1 1 0 1 1 1 1 Nitronate monooxygenase DHO_dh PF01180.16 EPA06105.1 - 8.9e-05 21.5 4.8 0.00031 19.8 0.9 2.1 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase NanE PF04131.9 EPA06105.1 - 0.00026 20.0 1.8 0.00051 19.0 1.2 1.5 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase PK PF00224.16 EPA06105.1 - 0.0043 15.7 0.0 0.0054 15.4 0.0 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PEP_mutase PF13714.1 EPA06105.1 - 0.005 16.0 0.4 0.014 14.6 0.0 1.7 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase B12-binding PF02310.14 EPA06105.1 - 0.01 15.7 0.1 0.021 14.7 0.1 1.4 1 0 0 1 1 1 1 B12 binding domain ThiG PF05690.9 EPA06105.1 - 0.014 14.4 2.2 0.019 14.0 0.3 1.9 1 1 0 1 1 1 0 Thiazole biosynthesis protein ThiG Response_reg PF00072.19 EPA06105.1 - 0.015 15.3 0.0 0.5 10.3 0.0 2.2 2 0 0 2 2 2 0 Response regulator receiver domain Aldolase PF01081.14 EPA06105.1 - 0.02 14.0 0.8 0.044 12.9 0.3 1.8 2 1 0 2 2 2 0 KDPG and KHG aldolase QRPTase_C PF01729.14 EPA06105.1 - 0.024 14.1 0.2 0.21 11.1 0.1 2.1 2 1 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain ADH_zinc_N PF00107.21 EPA06105.1 - 0.032 13.7 0.9 1.4 8.5 0.4 2.7 1 1 1 2 2 2 0 Zinc-binding dehydrogenase Glu_synthase PF01645.12 EPA06105.1 - 0.053 12.4 2.8 0.081 11.8 1.9 1.3 1 0 0 1 1 1 0 Conserved region in glutamate synthase PcrB PF01884.12 EPA06105.1 - 0.085 12.0 5.4 0.79 8.9 0.3 2.8 1 1 1 3 3 3 0 PcrB family IGPS PF00218.16 EPA06105.1 - 0.13 11.2 0.1 9.7 5.1 0.0 2.2 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase DeoC PF01791.4 EPA06105.1 - 0.15 11.3 6.0 2 7.6 4.2 2.2 1 1 0 1 1 1 0 DeoC/LacD family aldolase ATP-sulfurylase PF01747.12 EPA06106.1 - 1.3e-29 103.0 0.0 1.5e-29 102.8 0.0 1.0 1 0 0 1 1 1 1 ATP-sulfurylase DZR PF12773.2 EPA06111.1 - 0.029 14.1 9.7 0.042 13.6 6.7 1.3 1 0 0 1 1 1 0 Double zinc ribbon XkdN PF08890.6 EPA06111.1 - 0.18 11.5 0.4 0.2 11.3 0.3 1.0 1 0 0 1 1 1 0 Phage XkdN-like protein GF_recep_IV PF14843.1 EPA06111.1 - 0.19 11.3 7.8 0.2 11.2 5.4 1.1 1 0 0 1 1 1 0 Growth factor receptor domain IV zf-met PF12874.2 EPA06111.1 - 0.33 11.2 4.4 4.1 7.7 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type PolC_DP2 PF03833.8 EPA06111.1 - 0.38 8.3 6.2 0.39 8.3 4.3 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-ribbon_3 PF13248.1 EPA06111.1 - 0.7 9.1 7.0 0.13 11.5 1.4 2.0 1 1 1 2 2 2 0 zinc-ribbon domain C1_2 PF03107.11 EPA06111.1 - 1 9.5 10.9 6 7.0 1.4 3.7 3 1 0 3 3 3 0 C1 domain zf-dskA_traR PF01258.12 EPA06111.1 - 1.5 8.5 7.8 1.3 8.7 1.5 2.4 2 1 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger zf-C2H2_jaz PF12171.3 EPA06111.1 - 1.7 8.9 6.4 2.2 8.5 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding XPA_N PF01286.13 EPA06111.1 - 2.5 7.8 10.3 6.2 6.5 0.2 3.1 3 0 0 3 3 3 0 XPA protein N-terminal zf-B_box PF00643.19 EPA06111.1 - 3 7.7 12.2 9.4 6.2 7.6 2.1 1 1 0 1 1 1 0 B-box zinc finger Zn_Tnp_IS1595 PF12760.2 EPA06111.1 - 3.4 7.5 7.7 5.4 6.9 5.3 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-Sec23_Sec24 PF04810.10 EPA06111.1 - 3.8 7.1 7.5 13 5.4 5.2 1.8 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger DUF1272 PF06906.6 EPA06111.1 - 6.3 6.7 10.6 19 5.2 7.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) zf-MYND PF01753.13 EPA06111.1 - 7.3 6.5 11.1 47 3.9 7.7 2.1 1 1 0 1 1 1 0 MYND finger SelR PF01641.13 EPA06112.1 - 2.9e-51 172.3 0.2 3.3e-51 172.1 0.2 1.0 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.9 EPA06112.1 - 0.0021 18.0 0.3 0.018 15.1 0.0 2.1 2 0 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DZR PF12773.2 EPA06112.1 - 0.013 15.2 2.4 1.3 8.9 0.3 2.3 2 0 0 2 2 2 0 Double zinc ribbon DUF678 PF05077.7 EPA06112.1 - 0.087 12.8 0.3 11 6.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF678) TF_Zn_Ribbon PF08271.7 EPA06112.1 - 0.095 12.0 6.6 0.41 9.9 0.7 3.1 3 0 0 3 3 3 0 TFIIB zinc-binding RIG-I_C-RD PF11648.3 EPA06112.1 - 0.11 12.4 1.4 5.4 6.9 0.0 2.2 2 0 0 2 2 2 0 C-terminal domain of RIG-I HECT_2 PF09814.4 EPA06112.1 - 0.19 10.4 1.1 0.51 8.9 0.0 1.9 1 1 1 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Lar_restr_allev PF14354.1 EPA06112.1 - 0.27 11.5 3.3 1.4 9.3 1.7 2.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar zf-ribbon_3 PF13248.1 EPA06112.1 - 0.46 9.7 5.6 3.1 7.1 0.3 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.2 EPA06112.1 - 0.81 9.5 4.3 7.5 6.4 1.1 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain DUF983 PF06170.7 EPA06112.1 - 0.92 9.6 2.5 3.8 7.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF983) GCC2_GCC3 PF07699.8 EPA06113.1 - 0.00046 19.7 3.5 0.00059 19.3 2.4 1.4 1 1 0 1 1 1 1 GCC2 and GCC3 Ribosomal_S27e PF01667.12 EPA06113.1 - 0.31 10.6 0.2 0.31 10.6 0.1 2.1 1 1 1 2 2 2 0 Ribosomal protein S27 zf-RanBP PF00641.13 EPA06113.1 - 0.45 9.6 3.1 3.4 6.8 0.2 2.3 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Metallothio_PEC PF02068.11 EPA06113.1 - 1.5 9.2 13.1 1.9 8.9 9.1 1.3 1 1 0 1 1 1 0 Plant PEC family metallothionein GCD14 PF08704.5 EPA06115.1 - 2.3e-35 122.2 0.0 5.1e-35 121.1 0.0 1.5 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.1 EPA06115.1 - 1.6e-10 40.7 0.0 2.3e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EPA06115.1 - 2.3e-09 37.0 0.1 3.3e-09 36.6 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.13 EPA06115.1 - 8.7e-07 28.2 0.1 1.5e-06 27.5 0.1 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 EPA06115.1 - 1.2e-06 29.0 0.0 2.3e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EPA06115.1 - 5.1e-06 26.5 0.0 1.5e-05 24.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 EPA06115.1 - 1e-05 24.7 0.0 1.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_24 PF13578.1 EPA06115.1 - 1.3e-05 25.9 0.0 3.4e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.12 EPA06115.1 - 3.6e-05 22.8 0.1 5.8e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 O-methyltransferase PrmA PF06325.8 EPA06115.1 - 6.1e-05 22.2 0.0 8.2e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.7 EPA06115.1 - 9.3e-05 22.8 0.0 0.00021 21.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA06115.1 - 0.00012 22.4 0.0 0.00039 20.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 EPA06115.1 - 0.0004 19.8 0.0 0.00069 19.1 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 EPA06115.1 - 0.00059 19.2 0.0 0.0018 17.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Fibrillarin PF01269.12 EPA06115.1 - 0.00063 18.7 0.1 0.0011 17.8 0.1 1.3 1 0 0 1 1 1 1 Fibrillarin Methyltransf_25 PF13649.1 EPA06115.1 - 0.014 15.7 0.0 0.025 14.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.7 EPA06115.1 - 0.019 14.4 0.0 0.029 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) CMAS PF02353.15 EPA06115.1 - 0.02 13.9 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.1 EPA06115.1 - 0.022 14.4 0.0 0.042 13.5 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.13 EPA06115.1 - 0.023 14.2 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_23 PF13489.1 EPA06115.1 - 0.045 13.4 0.0 0.074 12.7 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain PQQ_3 PF13570.1 EPA06116.1 - 0.22 11.8 0.1 0.22 11.8 0.1 3.8 3 1 1 4 4 4 0 PQQ-like domain Carb_kinase PF01256.12 EPA06117.1 - 5.3e-48 163.4 0.5 6.2e-48 163.1 0.4 1.0 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.10 EPA06117.1 - 9.8e-10 38.0 0.2 1.9e-09 37.1 0.1 1.4 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.7 EPA06117.1 - 7.5e-06 25.3 0.0 1.1e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase AMP-binding PF00501.23 EPA06119.1 - 3.3e-96 322.2 0.0 4.2e-96 321.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EPA06119.1 - 1.3e-19 70.8 0.1 3e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Peptidase_M20 PF01546.23 EPA06121.1 - 2.6e-29 102.0 0.0 3.7e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EPA06121.1 - 8.1e-15 54.5 0.0 1.8e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Ribosomal_S21 PF01165.15 EPA06121.1 - 0.046 13.1 0.0 0.8 9.1 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein S21 DUF3818 PF12825.2 EPA06121.1 - 0.16 10.5 0.1 0.33 9.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) DUF2910 PF11139.3 EPA06122.1 - 0.0061 15.7 0.4 0.0063 15.6 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2910) DUF2339 PF10101.4 EPA06122.1 - 0.012 13.8 1.1 0.012 13.8 0.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) DUF998 PF06197.8 EPA06122.1 - 0.018 14.3 0.5 0.02 14.2 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF998) VIT1 PF01988.14 EPA06122.1 - 0.075 12.5 1.8 0.086 12.3 1.2 1.0 1 0 0 1 1 1 0 VIT family PLDc_N PF13396.1 EPA06122.1 - 0.1 12.2 0.6 0.1 12.2 0.4 1.6 1 1 1 2 2 2 0 Phospholipase_D-nuclease N-terminal PrgI PF12666.2 EPA06122.1 - 0.19 11.9 0.5 0.23 11.6 0.4 1.1 1 0 0 1 1 1 0 PrgI family protein DUF308 PF03729.8 EPA06122.1 - 0.81 9.7 10.1 2.5 8.1 7.0 1.7 1 1 0 1 1 1 0 Short repeat of unknown function (DUF308) DUF4064 PF13273.1 EPA06122.1 - 1.4 9.0 6.8 20 5.3 4.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) SdpI PF13630.1 EPA06122.1 - 3.5 7.4 8.0 21 4.9 5.9 1.8 1 1 0 1 1 1 0 SdpI/YhfL protein family DUF1056 PF06341.6 EPA06122.1 - 4.5 7.3 7.5 20 5.3 5.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1056) DUF4296 PF14129.1 EPA06123.1 - 0.037 14.1 5.0 0.29 11.3 2.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4296) Homeobox PF00046.24 EPA06123.1 - 0.047 13.3 1.2 0.074 12.6 0.8 1.3 1 0 0 1 1 1 0 Homeobox domain FB_lectin PF07367.6 EPA06123.1 - 0.052 13.1 0.6 0.059 12.9 0.4 1.1 1 0 0 1 1 1 0 Fungal fruit body lectin TDH PF03347.8 EPA06123.1 - 0.069 12.6 1.0 1 8.9 0.1 2.0 1 1 1 2 2 2 0 Vibrio thermostable direct hemolysin DUF3008 PF11450.3 EPA06123.1 - 0.13 12.4 0.3 0.2 11.8 0.0 1.5 2 0 0 2 2 2 0 Protein of unknwon function (DUF3008) Mst1_SARAH PF11629.3 EPA06123.1 - 0.29 10.9 5.2 0.51 10.1 3.1 1.9 1 1 0 1 1 1 0 C terminal SARAH domain of Mst1 Hydrolase_3 PF08282.7 EPA06124.1 - 4.4e-31 108.3 2.7 1.2e-21 77.4 0.1 2.0 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.8 EPA06124.1 - 7.7e-08 31.9 0.1 0.00041 19.7 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Trehalose_PPase PF02358.11 EPA06124.1 - 8e-08 31.4 0.0 0.0029 16.5 0.0 2.2 2 0 0 2 2 2 2 Trehalose-phosphatase HAD PF12710.2 EPA06124.1 - 2.4e-07 31.1 1.2 2.8e-05 24.3 0.0 2.6 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EPA06124.1 - 7e-06 26.6 0.3 0.0005 20.5 0.2 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EPA06124.1 - 0.088 12.5 0.1 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 HAD-hyrolase-like DUF504 PF04457.7 EPA06126.1 - 0.0037 17.3 0.1 0.0068 16.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF504) DUF2185 PF09951.4 EPA06126.1 - 0.031 14.0 0.1 0.05 13.4 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2185) YvbH_ext PF11724.3 EPA06127.1 - 0.0075 15.9 0.1 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 YvbH-like oligomerisation region UXS1_N PF11803.3 EPA06127.1 - 0.19 11.5 0.7 1.9 8.2 0.1 2.2 1 1 1 2 2 2 0 UDP-glucuronate decarboxylase N-terminal PUA PF01472.15 EPA06128.1 - 2.1e-16 59.3 0.6 2.9e-16 58.9 0.4 1.2 1 0 0 1 1 1 1 PUA domain DUF4362 PF14275.1 EPA06128.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4362) XPG_I PF00867.13 EPA06129.1 - 3.8e-24 84.5 0.0 8.3e-24 83.4 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 EPA06129.1 - 1.8e-21 76.3 0.0 6.9e-21 74.4 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain 5_3_exonuc PF01367.15 EPA06129.1 - 0.00013 22.0 0.0 0.00036 20.7 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold DoxX PF07681.7 EPA06130.1 - 2.9e-14 53.2 6.4 2.9e-14 53.2 4.4 1.6 1 1 0 1 1 1 1 DoxX DoxX_2 PF13564.1 EPA06130.1 - 1.6e-06 28.0 8.2 2.2e-06 27.5 5.4 1.4 1 1 0 1 1 1 1 DoxX-like family DoxD PF04173.8 EPA06130.1 - 2.3e-06 27.3 7.1 5.6e-06 26.1 4.8 1.6 1 1 1 2 2 2 1 TQO small subunit DoxD DUF4225 PF13988.1 EPA06130.1 - 1.4 8.4 12.7 0.14 11.6 3.2 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF4225) SURF4 PF02077.10 EPA06130.1 - 3.2 7.0 5.5 18 4.6 3.8 2.0 1 1 0 1 1 1 0 SURF4 family Band_7 PF01145.20 EPA06131.1 - 4.5e-25 88.5 6.2 6.9e-25 87.9 4.2 1.3 1 1 0 1 1 1 1 SPFH domain / Band 7 family Fer4_21 PF14697.1 EPA06132.1 - 0.04 13.7 2.1 0.048 13.5 1.5 1.1 1 0 0 1 1 1 0 4Fe-4S dicluster domain Zn_ribbon_2 PF12674.2 EPA06132.1 - 3.3 8.1 5.5 6 7.2 1.7 2.0 1 1 1 2 2 2 0 Putative zinc ribbon domain TrmB PF01978.14 EPA06133.1 - 8.2e-05 22.2 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HxlR PF01638.12 EPA06133.1 - 0.0033 17.0 0.0 0.0042 16.6 0.0 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix TFIIE_alpha PF02002.12 EPA06133.1 - 0.024 14.1 0.1 0.031 13.7 0.1 1.1 1 0 0 1 1 1 0 TFIIE alpha subunit GntR PF00392.16 EPA06133.1 - 0.081 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family DUF2042 PF09743.4 EPA06133.1 - 0.087 12.1 0.0 0.087 12.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2042) TauE PF01925.14 EPA06134.1 - 0.019 14.4 0.3 0.019 14.4 0.2 1.0 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE SdpI PF13630.1 EPA06134.1 - 0.046 13.4 2.8 0.057 13.1 1.9 1.1 1 0 0 1 1 1 0 SdpI/YhfL protein family Homoserine_dh PF00742.14 EPA06135.1 - 1.5e-54 184.3 0.2 2.6e-54 183.5 0.1 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.11 EPA06135.1 - 1.4e-06 28.6 0.0 3.8e-06 27.2 0.0 1.7 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.16 EPA06135.1 - 5.9e-06 26.0 0.3 1.6e-05 24.6 0.2 1.7 1 1 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase PAS_9 PF13426.1 EPA06136.1 - 1.2e-11 44.8 0.0 1.8e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 EPA06136.1 - 5.3e-09 35.8 0.0 6.8e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.5 EPA06136.1 - 0.00028 20.9 0.0 0.00034 20.6 0.0 1.1 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.6 EPA06136.1 - 0.0015 18.6 0.0 0.0023 17.9 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.1 EPA06136.1 - 0.097 12.5 0.0 0.29 11.0 0.0 1.7 2 0 0 2 2 2 0 PAS domain FlxA PF14282.1 EPA06136.1 - 0.11 12.4 0.3 0.16 11.8 0.2 1.3 1 0 0 1 1 1 0 FlxA-like protein Phage_holin_5 PF06946.6 EPA06137.1 - 0.4 10.8 5.4 0.16 12.1 1.5 1.9 2 0 0 2 2 2 0 Phage holin HCV_NS4b PF01001.14 EPA06137.1 - 2.1 7.7 9.6 0.34 10.2 2.5 2.2 2 1 0 2 2 2 0 Hepatitis C virus non-structural protein NS4b TerC PF03741.11 EPA06138.1 - 5.8e-51 172.5 13.1 5.8e-51 172.5 9.1 2.2 3 0 0 3 3 3 1 Integral membrane protein TerC family TGS PF02824.16 EPA06139.1 - 8.8e-21 73.5 0.1 2.5e-20 72.0 0.0 1.8 2 0 0 2 2 2 1 TGS domain MMR_HSR1 PF01926.18 EPA06139.1 - 1.5e-20 73.2 0.1 4.9e-20 71.6 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EPA06139.1 - 2.2e-15 56.2 1.0 6.1e-13 48.3 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B Dynamin_N PF00350.18 EPA06139.1 - 6.3e-05 22.8 0.1 0.48 10.2 0.1 2.9 2 0 0 2 2 2 2 Dynamin family cobW PF02492.14 EPA06139.1 - 0.00084 18.8 0.7 0.18 11.2 0.1 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AIG1 PF04548.11 EPA06139.1 - 0.0011 18.1 0.0 0.002 17.2 0.0 1.4 1 0 0 1 1 1 1 AIG1 family Arf PF00025.16 EPA06139.1 - 0.0027 16.9 1.6 0.032 13.4 0.0 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family DUF258 PF03193.11 EPA06139.1 - 0.0036 16.4 0.2 0.012 14.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function, DUF258 SRPRB PF09439.5 EPA06139.1 - 0.0048 16.1 0.9 0.0066 15.6 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit ArgK PF03308.11 EPA06139.1 - 0.011 14.4 0.1 0.069 11.9 0.0 2.1 2 0 0 2 2 2 0 ArgK protein Miro PF08477.8 EPA06139.1 - 0.012 16.1 0.0 0.035 14.5 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein AAA_28 PF13521.1 EPA06139.1 - 0.018 15.0 0.1 0.035 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 EPA06139.1 - 0.022 14.4 0.8 2.1 8.0 0.1 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 EPA06139.1 - 0.023 14.8 0.1 0.28 11.3 0.0 2.5 2 1 0 2 2 2 0 AAA domain Baculo_FP PF03258.9 EPA06139.1 - 0.024 13.7 6.5 0.66 9.0 0.0 2.7 3 0 0 3 3 3 0 Baculovirus FP protein AAA_16 PF13191.1 EPA06139.1 - 0.033 14.1 0.0 0.092 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Ras PF00071.17 EPA06139.1 - 0.059 12.7 1.2 4 6.7 0.0 2.3 2 0 0 2 2 2 0 Ras family AAA_33 PF13671.1 EPA06139.1 - 0.074 12.9 0.1 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EPA06139.1 - 0.088 13.6 0.5 0.36 11.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF904 PF06005.7 EPA06139.1 - 3 8.2 6.0 0.54 10.5 0.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF904) DUF1410 PF07198.6 EPA06140.1 - 0.03 14.6 2.9 0.062 13.6 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1410) SAC3 PF12209.3 EPA06141.1 - 0.022 14.9 0.0 0.17 12.0 0.1 2.0 2 0 0 2 2 2 0 Leucine permease transcriptional regulator helical domain YodL PF14191.1 EPA06141.1 - 0.022 15.2 0.4 0.027 14.9 0.3 1.1 1 0 0 1 1 1 0 YodL-like tRNA-synt_1d PF00750.14 EPA06143.1 - 1.6e-38 132.4 8.9 4.5e-28 98.0 0.4 2.6 2 1 1 3 3 3 2 tRNA synthetases class I (R) DALR_1 PF05746.10 EPA06143.1 - 5.5e-28 97.3 0.1 3e-27 94.9 0.0 2.3 3 0 0 3 3 3 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 EPA06143.1 - 5.3e-16 58.9 0.1 1.4e-15 57.5 0.1 1.8 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.14 EPA06143.1 - 0.00069 18.8 2.2 0.00071 18.7 0.1 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 EPA06143.1 - 0.0027 16.4 0.1 0.0071 15.0 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1f PF01921.13 EPA06143.1 - 0.014 14.1 0.6 0.073 11.7 0.1 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (K) Amidase_6 PF12671.2 EPA06143.1 - 0.07 13.1 0.8 0.37 10.8 0.2 2.1 2 0 0 2 2 2 0 Putative amidase domain Ribosomal_L29 PF00831.18 EPA06144.1 - 0.054 13.1 2.3 2.1 8.0 0.3 3.0 2 1 1 3 3 3 0 Ribosomal L29 protein CBFD_NFYB_HMF PF00808.18 EPA06144.1 - 0.057 13.4 0.2 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF2458 PF10454.4 EPA06144.1 - 0.064 13.1 6.6 0.11 12.3 4.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) Baculo_PEP_C PF04513.7 EPA06144.1 - 0.068 12.9 0.7 0.15 11.9 0.5 1.6 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4446 PF14584.1 EPA06144.1 - 1.3 8.8 5.9 1.8 8.3 1.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF4164 PF13747.1 EPA06144.1 - 1.9 8.6 9.9 2.3 8.4 5.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) TMPIT PF07851.8 EPA06144.1 - 7.1 5.6 9.1 21 4.0 5.1 2.0 1 1 1 2 2 2 0 TMPIT-like protein HTH_20 PF12840.2 EPA06145.1 - 4.2e-08 32.8 0.0 1.8e-07 30.8 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.2 EPA06145.1 - 3.9e-06 26.4 0.1 0.00091 18.8 0.0 2.3 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.1 EPA06145.1 - 6.8e-05 22.1 0.4 0.0008 18.7 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding DUF4423 PF14394.1 EPA06145.1 - 0.00063 19.3 0.0 0.0016 18.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) MarR PF01047.17 EPA06145.1 - 0.001 18.6 0.5 1.6 8.5 0.0 3.1 3 0 0 3 3 3 2 MarR family DUF2250 PF10007.4 EPA06145.1 - 0.0021 17.9 1.1 0.14 12.0 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2250) HTH_45 PF14947.1 EPA06145.1 - 0.0035 17.1 1.1 0.055 13.2 0.0 2.6 3 0 0 3 3 3 1 Winged helix-turn-helix HTH_27 PF13463.1 EPA06145.1 - 0.0059 16.9 0.1 0.63 10.3 0.0 2.4 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_5 PF01022.15 EPA06145.1 - 0.0071 15.9 0.1 0.024 14.3 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family TrmB PF01978.14 EPA06145.1 - 0.024 14.3 0.1 1.1 9.0 0.0 2.4 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DUF3449 PF11931.3 EPA06145.1 - 0.041 13.3 1.0 0.069 12.6 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) B-block_TFIIIC PF04182.7 EPA06145.1 - 0.062 13.1 0.3 17 5.3 0.0 3.2 2 1 0 3 3 3 0 B-block binding subunit of TFIIIC Mrr_N PF14338.1 EPA06145.1 - 0.1 12.7 0.0 0.33 11.0 0.0 1.9 2 0 0 2 2 2 0 Mrr N-terminal domain Thy1 PF02511.10 EPA06146.1 - 2.7e-29 101.8 3.0 4e-15 55.6 3.1 2.9 2 2 0 2 2 2 2 Thymidylate synthase complementing protein NOSIC PF08060.8 EPA06146.1 - 0.027 14.2 0.0 0.83 9.5 0.0 3.0 3 0 0 3 3 3 0 NOSIC (NUC001) domain Proteasome PF00227.21 EPA06147.1 - 6.4e-46 156.0 0.0 7.9e-46 155.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit PHO4 PF01384.15 EPA06148.1 - 2.6e-98 328.6 40.3 3.1e-98 328.4 27.9 1.1 1 0 0 1 1 1 1 Phosphate transporter family HTH_IclR PF09339.5 EPA06148.1 - 0.035 13.7 0.2 0.19 11.3 0.0 2.1 2 0 0 2 2 2 0 IclR helix-turn-helix domain DUF900 PF05990.7 EPA06149.1 - 3.4e-10 39.6 0.0 4.5e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) DUF726 PF05277.7 EPA06149.1 - 1.2e-09 37.4 0.0 1.7e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) LCAT PF02450.10 EPA06149.1 - 7.5e-05 21.8 0.1 0.00019 20.5 0.0 1.7 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.9 EPA06149.1 - 7.5e-05 22.1 0.2 0.00014 21.2 0.2 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF1749 PF08538.5 EPA06149.1 - 0.00028 19.8 0.0 0.00044 19.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) DUF2305 PF10230.4 EPA06149.1 - 0.00054 19.4 0.1 0.00081 18.8 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Cutinase PF01083.17 EPA06149.1 - 0.00065 19.4 0.0 0.00085 19.0 0.0 1.2 1 0 0 1 1 1 1 Cutinase Lipase_3 PF01764.20 EPA06149.1 - 0.00097 18.7 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 EPA06149.1 - 0.0017 18.1 0.0 0.0021 17.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF3089 PF11288.3 EPA06149.1 - 0.042 13.0 0.0 0.058 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) DUF2424 PF10340.4 EPA06149.1 - 0.045 12.3 0.0 0.092 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) PhoU_div PF01865.11 EPA06151.1 - 4.5e-23 81.5 12.4 5.1e-23 81.3 8.6 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF47 DUF643 PF04867.7 EPA06151.1 - 0.01 16.2 3.1 0.25 11.7 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF643) TetR_C_6 PF13977.1 EPA06151.1 - 0.034 14.1 0.0 0.063 13.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial transcriptional repressor COLFI PF01410.13 EPA06151.1 - 0.044 13.2 0.1 0.056 12.8 0.1 1.2 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain DXP_synthase_N PF13292.1 EPA06151.1 - 0.053 12.4 0.9 0.36 9.7 0.0 2.0 2 0 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase PhoU PF01895.14 EPA06151.1 - 0.073 13.5 12.1 0.2 12.1 1.9 2.6 1 1 1 2 2 2 0 PhoU domain Med4 PF10018.4 EPA06151.1 - 0.11 11.9 1.9 0.14 11.5 0.6 1.7 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Ferritin PF00210.19 EPA06151.1 - 0.17 11.6 4.3 0.14 11.8 0.5 2.4 2 2 0 2 2 2 0 Ferritin-like domain DUF552 PF04472.7 EPA06151.1 - 0.51 10.2 3.8 1.5 8.7 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF552) MCPsignal PF00015.16 EPA06151.1 - 0.57 9.6 7.0 5.8 6.4 1.9 2.5 2 2 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain ThiF PF00899.16 EPA06151.1 - 2.1 8.1 5.9 1.7 8.4 0.5 2.3 1 1 1 2 2 2 0 ThiF family tRNA-synt_1e PF01406.14 EPA06151.1 - 6.1 5.8 8.6 0.67 9.0 0.5 2.0 1 1 1 2 2 2 0 tRNA synthetases class I (C) catalytic domain DFF40 PF09230.5 EPA06152.1 - 0.12 11.6 0.3 0.12 11.6 0.2 1.0 1 0 0 1 1 1 0 DNA fragmentation factor 40 kDa tRNA-synt_1g PF09334.6 EPA06153.1 - 1.2e-13 50.4 0.1 1.8e-13 49.9 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) Anticodon_1 PF08264.8 EPA06153.1 - 1.1e-07 31.7 0.0 1.4e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA AAR2 PF05282.6 EPA06153.1 - 0.027 13.3 0.0 0.029 13.2 0.0 1.2 1 0 0 1 1 1 0 AAR2 protein Endotoxin_N PF03945.9 EPA06153.1 - 0.072 12.4 0.0 0.098 12.0 0.0 1.3 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain zinc_ribbon_5 PF13719.1 EPA06154.1 - 0.021 14.4 0.7 0.27 10.8 0.2 2.0 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA06154.1 - 0.028 14.0 0.6 0.4 10.3 0.2 2.1 2 0 0 2 2 2 0 zinc-ribbon domain NurA PF09376.5 EPA06157.1 - 6.1e-19 68.4 0.1 9.5e-19 67.8 0.0 1.3 1 0 0 1 1 1 1 NurA domain OpuAC PF04069.7 EPA06157.1 - 0.065 12.5 0.0 0.12 11.6 0.0 1.3 1 1 0 1 1 1 0 Substrate binding domain of ABC-type glycine betaine transport system WW PF00397.21 EPA06157.1 - 0.15 11.9 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 WW domain SMC_N PF02463.14 EPA06159.1 - 7.4e-17 61.3 23.7 3.6e-10 39.4 0.9 2.6 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EPA06159.1 - 1e-11 45.3 25.2 1.8e-06 28.1 6.2 3.3 1 1 1 2 2 2 2 AAA domain AAA_23 PF13476.1 EPA06159.1 - 2.8e-11 44.1 86.6 7.3e-11 42.7 37.4 3.9 1 1 1 2 2 1 1 AAA domain AAA_29 PF13555.1 EPA06159.1 - 1.1e-08 34.5 0.2 2.3e-08 33.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 EPA06159.1 - 2.5e-08 33.4 53.6 0.00051 19.1 22.4 2.3 1 1 1 2 2 2 2 AAA ATPase domain SbcCD_C PF13558.1 EPA06159.1 - 4.4e-08 32.9 0.1 9e-08 31.9 0.1 1.5 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.22 EPA06159.1 - 0.00016 21.9 23.2 0.0097 16.2 0.1 5.1 2 1 0 2 2 2 1 ABC transporter AAA_13 PF13166.1 EPA06159.1 - 0.00035 19.1 64.6 0.00061 18.3 17.0 4.4 1 1 3 4 4 4 2 AAA domain DUF258 PF03193.11 EPA06159.1 - 0.00094 18.4 0.6 0.0054 15.9 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 DNA_ligase_ZBD PF03119.11 EPA06159.1 - 0.06 13.0 0.2 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Reo_sigmaC PF04582.7 EPA06159.1 - 0.09 11.9 5.8 0.7 9.0 0.8 2.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein zf-C3HC4_3 PF13920.1 EPA06159.1 - 0.22 11.2 0.9 0.33 10.6 0.0 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) MMR_HSR1 PF01926.18 EPA06159.1 - 0.26 11.2 4.5 0.36 10.7 0.0 3.2 3 1 0 3 3 3 0 50S ribosome-binding GTPase DUF87 PF01935.12 EPA06162.1 - 3.2e-37 128.5 3.3 3.2e-37 128.5 2.3 1.6 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_10 PF12846.2 EPA06162.1 - 1.1e-14 54.5 6.1 2.7e-10 40.1 1.3 2.1 1 1 0 2 2 2 2 AAA-like domain TrwB_AAD_bind PF10412.4 EPA06162.1 - 0.0039 15.8 0.2 0.011 14.3 0.0 1.9 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain HAS-barrel PF09378.5 EPA06162.1 - 0.031 14.1 0.0 0.081 12.8 0.0 1.8 1 0 0 1 1 1 0 HAS barrel domain ABC_tran PF00005.22 EPA06162.1 - 0.068 13.4 1.6 0.15 12.3 1.1 1.6 1 1 0 1 1 1 0 ABC transporter Metallophos_2 PF12850.2 EPA06163.1 - 1.5e-11 44.4 0.5 2.1e-11 43.9 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 EPA06163.1 - 1.4e-09 37.6 5.0 2.2e-09 37.0 3.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CENP-C_C PF11699.3 EPA06163.1 - 0.019 14.9 0.0 0.042 13.8 0.0 1.5 1 0 0 1 1 1 0 Mif2/CENP-C like DUF211 PF02680.9 EPA06163.1 - 0.28 10.9 3.6 32 4.4 0.1 3.6 3 1 1 4 4 4 0 Uncharacterized ArCR, COG1888 Ribosomal_S14 PF00253.16 EPA06165.1 - 0.079 12.3 0.8 0.28 10.5 0.0 1.9 2 0 0 2 2 2 0 Ribosomal protein S14p/S29e N6_N4_Mtase PF01555.13 EPA06167.1 - 2.9e-45 154.5 0.0 5.1e-45 153.7 0.0 1.4 1 0 0 1 1 1 1 DNA methylase Methyltransf_26 PF13659.1 EPA06167.1 - 4.6e-11 42.7 0.0 7e-05 22.8 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain UPF0020 PF01170.13 EPA06167.1 - 3.2e-09 36.6 0.0 0.00021 20.9 0.0 2.5 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.1 EPA06167.1 - 1.4e-07 31.1 0.1 2.6e-06 27.0 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA06167.1 - 2.2e-05 24.8 0.0 0.025 15.0 0.0 2.8 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_25 PF13649.1 EPA06167.1 - 0.00064 20.0 0.0 0.002 18.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA06167.1 - 0.006 17.1 0.0 0.012 16.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 EPA06167.1 - 0.021 14.4 0.0 1.3 8.5 0.0 2.3 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase Methyltransf_12 PF08242.7 EPA06167.1 - 0.087 13.3 0.0 3 8.3 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain Adenine_glyco PF03352.8 EPA06168.1 - 6.1e-77 257.1 0.9 7.8e-77 256.8 0.6 1.1 1 0 0 1 1 1 1 Methyladenine glycosylase Mut7-C PF01927.11 EPA06169.1 - 0.0031 17.5 0.0 0.0035 17.3 0.0 1.1 1 0 0 1 1 1 1 Mut7-C RNAse domain Phage_integrase PF00589.17 EPA06170.1 - 2.2e-08 33.9 0.0 9.4e-08 31.9 0.0 2.1 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_4 PF13495.1 EPA06170.1 - 0.0083 16.4 0.2 0.094 13.0 0.1 2.7 2 1 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Tup_N PF08581.5 EPA06170.1 - 0.08 13.1 6.0 0.19 11.9 1.2 3.0 2 0 0 2 2 2 0 Tup N-terminal EVE PF01878.13 EPA06172.1 - 7.8e-07 29.2 0.0 3e-06 27.3 0.0 1.7 1 1 0 1 1 1 1 EVE domain Antitoxin-MazE PF04014.13 EPA06173.1 - 1.7e-07 30.8 0.1 2e-07 30.5 0.1 1.1 1 0 0 1 1 1 1 Antidote-toxin recognition MazE HTH_24 PF13412.1 EPA06174.1 - 0.00034 19.9 0.1 0.0011 18.3 0.0 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.14 EPA06174.1 - 0.0014 18.2 0.0 0.0035 16.9 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.17 EPA06174.1 - 0.0035 17.0 0.5 0.024 14.3 0.1 2.4 2 0 0 2 2 2 1 MarR family MarR_2 PF12802.2 EPA06174.1 - 0.004 16.8 0.0 0.039 13.6 0.0 2.2 2 0 0 2 2 2 1 MarR family RPA_C PF08784.6 EPA06174.1 - 0.017 15.5 0.2 0.043 14.2 0.2 1.7 1 0 0 1 1 1 0 Replication protein A C terminal Hom_end_hint PF05203.11 EPA06174.1 - 0.024 14.3 0.7 1.9 8.1 0.0 2.2 2 0 0 2 2 2 0 Hom_end-associated Hint EAP30 PF04157.11 EPA06174.1 - 0.035 13.2 0.4 0.15 11.2 0.0 2.0 2 0 0 2 2 2 0 EAP30/Vps36 family Rio2_N PF09202.6 EPA06174.1 - 0.081 13.0 0.0 0.23 11.5 0.0 1.8 1 0 0 1 1 1 0 Rio2, N-terminal B12-binding_2 PF02607.12 EPA06175.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 B12 binding domain HATPase_c_3 PF13589.1 EPA06176.1 - 1.1e-07 31.5 0.5 2.2e-07 30.6 0.4 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 EPA06176.1 - 1.6e-05 24.5 0.1 4.8e-05 23.0 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3936 PF13072.1 EPA06177.1 - 0.24 10.8 0.2 0.24 10.8 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3936) DUF1837 PF08878.6 EPA06178.1 - 4.7e-11 42.7 7.5 7.1e-11 42.1 5.2 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF1837) ORF6C PF10552.4 EPA06179.1 - 0.037 13.7 2.5 0.066 12.9 1.8 1.4 1 0 0 1 1 1 0 ORF6C domain DUF3511 PF12023.3 EPA06179.1 - 0.051 12.8 0.1 0.29 10.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3511) DUF1188 PF06690.6 EPA06179.1 - 0.059 12.5 0.2 0.11 11.6 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) Ribosomal_S4e PF00900.15 EPA06179.1 - 0.099 12.3 0.4 0.2 11.3 0.3 1.6 1 1 0 1 1 1 0 Ribosomal family S4e Pterin_4a PF01329.14 EPA06179.1 - 0.11 12.3 0.2 0.29 10.9 0.1 1.8 2 0 0 2 2 2 0 Pterin 4 alpha carbinolamine dehydratase Phe_tRNA-synt_N PF02912.13 EPA06179.1 - 0.28 10.9 5.6 0.17 11.5 0.6 2.5 2 1 1 3 3 3 0 Aminoacyl tRNA synthetase class II, N-terminal domain DUF4351 PF14261.1 EPA06180.1 - 0.054 13.3 0.5 0.14 12.0 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4351) Ribosomal_L13e PF01294.13 EPA06180.1 - 0.084 12.3 0.1 0.1 12.0 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L13e MitMem_reg PF13012.1 EPA06182.1 - 0.011 15.7 2.0 0.012 15.7 1.4 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function Flagellar_rod PF05149.7 EPA06182.1 - 0.027 13.6 3.7 0.03 13.5 2.5 1.0 1 0 0 1 1 1 0 Paraflagellar rod protein DNA_methylase PF00145.12 EPA06184.1 - 2e-55 188.2 0.1 3.9e-55 187.3 0.1 1.4 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase PilJ PF13675.1 EPA06184.1 - 0.11 12.8 0.0 5.2 7.4 0.0 2.9 3 0 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term HhH-GPD PF00730.20 EPA06185.1 - 1.1e-15 57.8 0.0 1.8e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 EPA06185.1 - 6.7e-11 41.2 0.0 1.5e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.4 EPA06185.1 - 4.5e-06 26.6 6.4 8.2e-06 25.8 4.5 1.4 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III HRDC PF00570.18 EPA06185.1 - 0.066 12.9 0.0 1.2 8.8 0.0 2.8 2 0 0 2 2 2 0 HRDC domain DEAD PF00270.24 EPA06187.1 - 1e-25 90.1 0.0 2.5e-25 88.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EPA06187.1 - 2.1e-11 43.4 0.3 4.9e-11 42.3 0.2 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HIRAN PF08797.6 EPA06187.1 - 2.1e-08 34.0 0.0 5.4e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 HIRAN domain ResIII PF04851.10 EPA06187.1 - 1.2e-06 28.5 0.0 4.1e-06 26.7 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 EPA06187.1 - 0.0059 16.2 0.0 0.013 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain SNF2_N PF00176.18 EPA06187.1 - 0.0066 15.2 0.0 0.015 14.1 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Lactamase_B_2 PF12706.2 EPA06188.1 - 2.4e-15 56.5 1.6 2.7e-14 53.1 0.1 2.7 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 EPA06188.1 - 3.9e-09 36.4 5.8 4.8e-08 32.8 4.0 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.7 EPA06188.1 - 9.8e-06 25.2 1.8 0.00012 21.8 0.0 2.8 2 0 0 2 2 2 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_3 PF13483.1 EPA06188.1 - 3.6e-05 23.5 0.0 0.00011 22.0 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain SIS PF01380.17 EPA06188.1 - 0.053 13.1 0.0 11 5.6 0.0 2.5 2 0 0 2 2 2 0 SIS domain Ephrin_lbd PF01404.14 EPA06189.1 - 0.037 13.8 0.0 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 Ephrin receptor ligand binding domain Ribonuc_red_lgC PF02867.10 EPA06190.1 - 4.5e-154 513.9 0.0 1.1e-153 512.6 0.0 1.7 2 0 0 2 2 2 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 EPA06190.1 - 4.1e-31 106.6 0.0 8.9e-31 105.5 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 EPA06190.1 - 1.1e-23 83.4 2.1 3.5e-23 81.8 0.8 2.3 2 0 0 2 2 2 1 ATP cone domain TGFb_propeptide PF00688.13 EPA06192.1 - 0.014 14.7 0.1 1.3 8.2 0.0 2.1 2 0 0 2 2 2 0 TGF-beta propeptide Peptidase_S8 PF00082.17 EPA06193.1 - 5.4e-26 91.3 6.8 5.6e-18 65.0 0.3 2.4 2 0 0 2 2 2 2 Subtilase family DZR PF12773.2 EPA06194.1 - 0.02 14.7 0.9 0.025 14.3 0.6 1.1 1 0 0 1 1 1 0 Double zinc ribbon zf-C3HC4_3 PF13920.1 EPA06194.1 - 0.035 13.7 0.9 0.047 13.3 0.6 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FHIPEP PF00771.15 EPA06194.1 - 0.043 12.1 0.0 0.043 12.1 0.0 1.0 1 0 0 1 1 1 0 FHIPEP family DUF1272 PF06906.6 EPA06194.1 - 0.067 13.0 1.4 0.099 12.5 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) PHO4 PF01384.15 EPA06194.1 - 0.13 10.9 0.1 0.13 10.8 0.1 1.1 1 0 0 1 1 1 0 Phosphate transporter family PolC_DP2 PF03833.8 EPA06194.1 - 0.13 9.8 0.0 0.13 9.8 0.0 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-ribbon_3 PF13248.1 EPA06194.1 - 0.13 11.4 3.6 1.3 8.2 0.4 2.1 1 1 1 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 EPA06194.1 - 0.2 11.1 3.3 7.6 6.1 0.4 2.2 2 0 0 2 2 2 0 zinc-ribbon domain DNA_ligase_ZBD PF03119.11 EPA06194.1 - 0.32 10.7 2.6 3.3 7.5 0.4 2.2 1 1 1 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain TF_Zn_Ribbon PF08271.7 EPA06194.1 - 0.86 8.9 7.2 5 6.5 0.4 2.2 1 1 1 2 2 2 0 TFIIB zinc-binding RTBV_P46 PF06216.6 EPA06195.1 - 0.36 9.6 10.3 0.048 12.5 4.2 1.7 1 1 0 2 2 2 0 Rice tungro bacilliform virus P46 protein Baculo_PEP_C PF04513.7 EPA06195.1 - 0.54 10.0 14.5 1.4 8.7 1.5 2.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1395 PF07160.7 EPA06195.1 - 2.6 7.4 25.5 0.24 10.8 7.8 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1395) MCPsignal PF00015.16 EPA06195.1 - 2.9 7.3 24.3 1.8 8.0 8.6 2.3 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Reo_sigmaC PF04582.7 EPA06195.1 - 4.7 6.2 10.8 16 4.5 6.4 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF1664 PF07889.7 EPA06195.1 - 5.8 6.7 27.9 0.63 9.8 4.9 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF745 PF05335.8 EPA06195.1 - 5.9 6.3 31.3 0.37 10.2 5.6 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF745) ING PF12998.2 EPA06195.1 - 6.8 7.0 26.5 1.5e+04 -9.0 18.4 3.2 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding ABC1 PF03109.11 EPA06195.1 - 7.7 6.5 10.4 0.28 11.1 0.4 2.8 2 1 1 3 3 3 0 ABC1 family COG2 PF06148.6 EPA06195.1 - 7.7 6.3 27.6 2.3 8.0 4.1 3.7 1 1 3 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 PAP2 PF01569.16 EPA06196.1 - 3.5e-18 65.5 0.8 4e-18 65.3 0.5 1.0 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.1 EPA06196.1 - 2.9e-06 26.9 0.2 3.5e-06 26.6 0.2 1.1 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.1 EPA06196.1 - 6.8e-06 26.2 0.1 9e-06 25.8 0.1 1.1 1 0 0 1 1 1 1 PAP2 superfamily C-terminal PrsW-protease PF13367.1 EPA06196.1 - 0.14 11.3 1.4 0.26 10.4 1.0 1.5 1 1 0 1 1 1 0 Protease prsW family Ribosomal_S28e PF01200.13 EPA06198.1 - 4.2e-29 100.0 4.6 4.5e-29 99.9 3.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e KOW PF00467.24 EPA06198.1 - 0.044 13.5 1.0 0.12 12.1 0.1 2.2 2 0 0 2 2 2 0 KOW motif tRNA-synt_His PF13393.1 EPA06199.1 - 4.3e-27 94.9 0.0 4.8e-27 94.8 0.0 1.0 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 EPA06199.1 - 1.5e-17 63.7 0.0 1.9e-17 63.3 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.15 EPA06199.1 - 7.4e-05 22.0 0.0 9.3e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) YHS PF04945.8 EPA06200.1 - 4.5e-18 64.8 1.0 4.7e-18 64.7 0.7 1.0 1 0 0 1 1 1 1 YHS domain Arc_trans_TRASH PF08394.5 EPA06200.1 - 0.00023 21.2 0.8 0.0003 20.8 0.6 1.2 1 0 0 1 1 1 1 Archaeal TRASH domain zf-FCS PF06467.9 EPA06200.1 - 0.0052 16.3 0.8 0.0056 16.2 0.5 1.2 1 0 0 1 1 1 1 MYM-type Zinc finger with FCS sequence motif DUF581 PF04570.9 EPA06200.1 - 0.054 12.7 0.4 0.059 12.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF581) Radical_SAM PF04055.16 EPA06201.1 - 4.4e-16 59.5 0.1 1.1e-15 58.1 0.0 1.7 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_14 PF13394.1 EPA06201.1 - 4.1e-05 23.5 0.3 0.00031 20.7 0.0 2.3 2 1 0 2 2 2 1 4Fe-4S single cluster domain zf-ribbon_3 PF13248.1 EPA06203.1 - 6.8e-09 34.6 3.5 1.2e-08 33.9 2.4 1.4 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_2 PF13240.1 EPA06203.1 - 8.2e-09 34.6 12.9 3.9e-07 29.3 4.1 1.9 1 1 1 2 2 2 2 zinc-ribbon domain DZR PF12773.2 EPA06203.1 - 4.3e-06 26.4 2.1 6.7e-06 25.8 1.5 1.3 1 0 0 1 1 1 1 Double zinc ribbon UPF0547 PF10571.4 EPA06203.1 - 1.2e-05 24.8 2.1 3.2e-05 23.4 1.4 1.7 1 1 0 1 1 1 1 Uncharacterised protein family UPF0547 Nudix_N_2 PF14803.1 EPA06203.1 - 0.0073 15.9 9.2 0.087 12.5 0.2 2.7 3 0 0 3 3 3 2 Nudix N-terminal RNA_POL_M_15KD PF02150.11 EPA06203.1 - 0.023 14.3 3.6 2.1 8.0 0.4 2.4 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit Prok-RING_1 PF14446.1 EPA06203.1 - 0.024 14.3 1.2 0.033 13.9 0.8 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-NADH-PPase PF09297.6 EPA06203.1 - 0.054 13.0 6.0 5.5 6.5 4.1 2.2 1 1 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain C1_1 PF00130.17 EPA06203.1 - 0.062 13.0 0.6 0.092 12.4 0.4 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) GFA PF04828.9 EPA06203.1 - 0.091 12.7 4.2 1.7 8.6 0.1 2.5 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme RRN7 PF11781.3 EPA06203.1 - 0.099 12.1 0.2 16 5.1 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 A2L_zn_ribbon PF08792.5 EPA06203.1 - 0.13 11.7 3.6 2 8.0 0.2 2.3 2 0 0 2 2 2 0 A2L zinc ribbon domain TF_Zn_Ribbon PF08271.7 EPA06203.1 - 0.15 11.4 2.2 4.4 6.7 0.2 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding Auto_anti-p27 PF06677.7 EPA06203.1 - 0.24 11.1 4.3 2.4 7.9 2.9 2.2 1 1 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) NOB1_Zn_bind PF08772.6 EPA06203.1 - 0.28 11.0 7.8 3.9 7.3 0.5 2.4 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-tcix PF14952.1 EPA06203.1 - 0.81 9.0 6.2 2.6 7.4 0.5 2.2 1 1 1 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding YhfH PF14149.1 EPA06203.1 - 0.89 9.3 4.4 7.7 6.3 0.1 2.3 1 1 1 2 2 2 0 YhfH-like protein OrfB_Zn_ribbon PF07282.6 EPA06203.1 - 0.95 9.1 2.9 1.8 8.2 2.0 1.5 1 1 0 1 1 1 0 Putative transposase DNA-binding domain zf-dskA_traR PF01258.12 EPA06203.1 - 1.3 8.8 3.6 11 5.8 0.1 2.3 1 1 1 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger DZR PF12773.2 EPA06204.1 - 3.4e-06 26.7 10.8 0.00032 20.4 2.8 2.4 2 0 0 2 2 2 2 Double zinc ribbon PRC PF05239.11 EPA06204.1 - 4.5e-06 26.4 0.5 8.4e-06 25.5 0.4 1.4 1 0 0 1 1 1 1 PRC-barrel domain zinc_ribbon_2 PF13240.1 EPA06204.1 - 8.1e-05 21.9 7.4 8.1e-05 21.9 5.1 2.1 2 0 0 2 2 2 1 zinc-ribbon domain zf-ribbon_3 PF13248.1 EPA06204.1 - 0.00014 20.9 6.4 0.00014 20.9 4.4 2.5 3 0 0 3 3 3 1 zinc-ribbon domain GFA PF04828.9 EPA06204.1 - 0.0017 18.2 5.9 5.9 6.9 0.1 3.4 2 1 1 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme zf-B_box PF00643.19 EPA06204.1 - 0.019 14.8 11.1 1.5 8.8 0.7 3.2 3 0 0 3 3 3 0 B-box zinc finger zinc-ribbons_6 PF07191.7 EPA06204.1 - 0.034 13.9 6.9 7.5 6.4 0.9 3.2 3 0 0 3 3 3 0 zinc-ribbons Metaviral_G PF09595.5 EPA06204.1 - 0.062 12.9 3.0 0.089 12.4 2.1 1.1 1 0 0 1 1 1 0 Metaviral_G glycoprotein A2L_zn_ribbon PF08792.5 EPA06204.1 - 0.11 12.0 0.0 0.11 12.0 0.0 4.4 3 1 0 3 3 3 0 A2L zinc ribbon domain DNA_RNApol_7kD PF03604.8 EPA06204.1 - 0.27 10.7 10.7 2 7.9 0.0 4.2 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit DUF3279 PF11682.3 EPA06204.1 - 0.32 10.5 5.6 12 5.4 0.1 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF3279) Cript PF10235.4 EPA06204.1 - 0.37 11.1 4.0 0.82 10.0 0.1 3.0 3 0 0 3 3 3 0 Microtubule-associated protein CRIPT Prim_Zn_Ribbon PF08273.7 EPA06204.1 - 0.57 10.2 9.7 22 5.2 0.1 3.6 3 1 0 3 3 3 0 Zinc-binding domain of primase-helicase RRN7 PF11781.3 EPA06204.1 - 0.75 9.3 11.4 2.4 7.7 1.0 3.5 3 1 0 3 3 3 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-AD PF07776.10 EPA06204.1 - 1.1 9.3 5.9 1.2 9.1 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) DUF1033 PF06279.6 EPA06204.1 - 1.1 9.0 4.4 0.86 9.4 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1033) PHD PF00628.24 EPA06204.1 - 2.4 7.8 9.2 15 5.4 0.1 3.3 3 0 0 3 3 3 0 PHD-finger GCC2_GCC3 PF07699.8 EPA06204.1 - 6.3 6.4 12.7 1.4 8.5 2.9 3.2 3 0 0 3 3 3 0 GCC2 and GCC3 Thioredoxin PF00085.15 EPA06205.1 - 1.2e-28 98.8 0.1 1.6e-28 98.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 EPA06205.1 - 1.1e-08 35.0 0.5 8.6e-08 32.1 0.1 2.2 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.1 EPA06205.1 - 2.7e-08 34.0 0.1 1.8e-07 31.3 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 EPA06205.1 - 1.3e-06 27.9 0.4 2e-06 27.4 0.2 1.4 1 1 0 1 1 1 1 Thioredoxin Redoxin PF08534.5 EPA06205.1 - 2.6e-05 23.8 0.0 3.1e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Redoxin Phosducin PF02114.11 EPA06205.1 - 5e-05 22.1 0.0 5.5e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin_7 PF13899.1 EPA06205.1 - 9.7e-05 22.3 0.1 0.00017 21.5 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like HyaE PF07449.6 EPA06205.1 - 0.024 14.5 0.0 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE TraF PF13728.1 EPA06205.1 - 0.047 13.1 0.1 0.059 12.8 0.1 1.4 1 1 0 1 1 1 0 F plasmid transfer operon protein DUF836 PF05768.9 EPA06205.1 - 0.089 13.0 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) TF_Zn_Ribbon PF08271.7 EPA06206.1 - 0.0033 16.7 1.2 1.2 8.4 0.1 2.2 2 0 0 2 2 2 2 TFIIB zinc-binding zf-C2H2_6 PF13912.1 EPA06206.1 - 0.019 14.8 1.9 0.23 11.4 0.0 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger RRN7 PF11781.3 EPA06206.1 - 0.06 12.8 0.7 0.48 9.9 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-C2H2 PF00096.21 EPA06206.1 - 0.095 13.0 0.6 3.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type A2L_zn_ribbon PF08792.5 EPA06206.1 - 0.15 11.5 0.0 0.15 11.5 0.0 1.5 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-C2H2_3 PF13878.1 EPA06206.1 - 0.24 10.9 0.1 0.24 10.9 0.1 1.8 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO RecR PF02132.10 EPA06206.1 - 0.39 10.1 2.9 1.3 8.4 2.0 1.8 1 1 0 1 1 1 0 RecR protein ADK_lid PF05191.9 EPA06206.1 - 0.63 9.7 3.1 1.1 8.9 2.1 1.5 1 1 0 1 1 1 0 Adenylate kinase, active site lid LSM PF01423.17 EPA06208.1 - 6.5e-23 80.0 0.6 7.5e-23 79.8 0.4 1.0 1 0 0 1 1 1 1 LSM domain Cupredoxin_1 PF13473.1 EPA06209.1 - 3.2e-08 33.4 0.0 4.6e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Cupredoxin-like domain Cu-oxidase_2 PF07731.9 EPA06209.1 - 0.066 12.7 0.7 8.5 5.8 0.0 2.2 1 1 1 2 2 2 0 Multicopper oxidase COX2 PF00116.15 EPA06209.1 - 0.086 12.6 0.1 0.14 12.0 0.1 1.6 1 1 0 1 1 1 0 Cytochrome C oxidase subunit II, periplasmic domain Copper-bind PF00127.15 EPA06209.1 - 0.14 12.4 0.2 0.22 11.7 0.2 1.6 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family NicO PF03824.11 EPA06211.1 - 1e-08 34.8 19.6 2.5e-08 33.6 13.6 1.7 1 1 0 1 1 1 1 High-affinity nickel-transport protein DHquinase_II PF01220.14 EPA06211.1 - 0.0073 15.6 0.0 0.23 10.7 0.0 2.1 2 0 0 2 2 2 1 Dehydroquinase class II Gly-zipper_OmpA PF13436.1 EPA06211.1 - 0.92 9.1 3.6 0.44 10.2 0.1 2.1 2 2 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain PepSY_TM PF03929.11 EPA06211.1 - 2.9 8.4 0.0 2.9 8.4 0.0 4.2 3 1 1 4 4 4 0 PepSY-associated TM helix Archease PF01951.11 EPA06212.1 - 3.7e-32 111.1 2.1 4e-32 111.0 1.5 1.0 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) RdgC PF04381.7 EPA06212.1 - 0.014 14.3 0.5 0.017 14.0 0.4 1.1 1 0 0 1 1 1 0 Putative exonuclease, RdgC Ribosomal_L7Ae PF01248.21 EPA06213.1 - 1.4e-25 88.6 0.1 1.7e-25 88.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.1 EPA06213.1 - 0.028 14.2 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 PELOTA RNA binding domain DUF3055 PF11256.3 EPA06213.1 - 0.082 13.0 0.0 0.16 12.1 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3055) Creatininase PF02633.9 EPA06214.1 - 7.1e-55 185.6 0.0 8.5e-55 185.4 0.0 1.0 1 0 0 1 1 1 1 Creatinine amidohydrolase Peptidase_S24 PF00717.18 EPA06216.1 - 2.5e-07 30.2 3.8 4.4e-07 29.4 0.3 2.3 2 0 0 2 2 2 1 Peptidase S24-like SOR PF07682.6 EPA06216.1 - 0.024 13.2 1.6 0.029 12.9 0.2 1.7 2 0 0 2 2 2 0 Sulphur oxygenase reductase TrbC PF04956.8 EPA06216.1 - 0.91 9.5 4.8 3.9 7.5 0.7 2.2 2 0 0 2 2 2 0 TrbC/VIRB2 family Vpu PF00558.14 EPA06216.1 - 1.1 8.8 8.0 0.24 10.9 0.4 2.4 2 0 0 2 2 2 0 Vpu protein Amidohydro_4 PF13147.1 EPA06217.1 - 7.8e-24 85.1 0.0 1.6e-23 84.1 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 EPA06217.1 - 3.2e-10 40.1 1.0 3e-09 36.9 0.7 2.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EPA06217.1 - 6.8e-09 35.4 2.5 4.1e-08 32.9 2.0 2.1 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_3 PF07969.6 EPA06217.1 - 1.8e-06 27.4 0.4 1.1e-05 24.8 0.0 2.4 1 1 1 2 2 2 1 Amidohydrolase family TatD_DNase PF01026.16 EPA06217.1 - 3.2e-05 23.2 0.1 6.3e-05 22.2 0.1 1.7 1 1 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.9 EPA06217.1 - 0.059 12.9 0.0 0.097 12.2 0.0 1.4 1 0 0 1 1 1 0 Amidohydrolase Hom_end PF05204.9 EPA06217.1 - 0.14 12.1 0.0 2.6 8.0 0.0 2.4 2 0 0 2 2 2 0 Homing endonuclease DsbD PF02683.10 EPA06218.1 - 1.1e-17 64.3 17.4 1.1e-17 64.3 12.1 1.7 2 0 0 2 2 2 1 Cytochrome C biogenesis protein transmembrane region DsbD_2 PF13386.1 EPA06218.1 - 4e-08 33.2 21.3 4e-08 33.2 14.8 2.5 2 1 1 3 3 3 2 Cytochrome C biogenesis protein transmembrane region NicO PF03824.11 EPA06218.1 - 1.6 7.9 14.8 0.54 9.5 4.5 2.6 2 1 0 2 2 2 0 High-affinity nickel-transport protein Formyl_trans_N PF00551.14 EPA06219.1 - 7.8e-43 146.1 0.1 1.1e-42 145.6 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase ACT_6 PF13740.1 EPA06219.1 - 4.2e-09 35.9 0.0 1e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 ACT domain ACT PF01842.20 EPA06219.1 - 9e-05 21.8 0.1 0.00041 19.7 0.0 2.2 2 1 0 2 2 2 1 ACT domain ACT_4 PF13291.1 EPA06219.1 - 0.0074 16.5 0.3 0.033 14.5 0.0 2.2 1 1 1 2 2 2 1 ACT domain HpaB_N PF11794.3 EPA06221.1 - 1.2e-89 300.1 0.0 2.5e-89 299.1 0.0 1.5 2 0 0 2 2 2 1 4-hydroxyphenylacetate 3-hydroxylase N terminal HpaB PF03241.8 EPA06221.1 - 2.2e-70 235.6 0.2 3.2e-70 235.1 0.1 1.2 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase C terminal Bt_P21 PF05560.6 EPA06221.1 - 0.078 12.3 0.2 13 5.1 0.0 2.3 2 0 0 2 2 2 0 Bacillus thuringiensis P21 molecular chaperone protein Thioredoxin PF00085.15 EPA06222.1 - 7.9e-32 109.0 0.1 8.9e-32 108.8 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 EPA06222.1 - 2.3e-12 46.8 0.3 4.3e-08 33.1 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.1 EPA06222.1 - 6.3e-11 42.4 0.0 2e-10 40.8 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 EPA06222.1 - 1.9e-07 30.9 0.1 3e-07 30.3 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.1 EPA06222.1 - 9.6e-07 28.4 0.1 1.1e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.1 EPA06222.1 - 2.5e-06 27.2 0.1 3e-06 26.9 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin domain AhpC-TSA PF00578.16 EPA06222.1 - 1.4e-05 24.7 0.0 1.6e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EPA06222.1 - 5.3e-05 22.7 0.3 0.00014 21.4 0.2 1.6 1 1 0 1 1 1 1 Redoxin HyaE PF07449.6 EPA06222.1 - 0.00015 21.6 0.0 0.00019 21.2 0.0 1.2 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_4 PF13462.1 EPA06222.1 - 0.00066 19.7 0.1 0.16 11.9 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.1 EPA06222.1 - 0.0031 17.3 0.1 0.008 16.0 0.0 1.6 2 0 0 2 2 2 1 Thioredoxin-like domain DUF953 PF06110.6 EPA06222.1 - 0.0032 16.8 0.3 0.011 15.2 0.1 1.8 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) TraF PF13728.1 EPA06222.1 - 0.0067 15.9 0.0 0.008 15.6 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein DUF836 PF05768.9 EPA06222.1 - 0.036 14.3 0.0 0.046 13.9 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) DSBA PF01323.15 EPA06222.1 - 0.076 12.5 0.1 0.91 9.0 0.0 2.0 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Glutaredoxin PF00462.19 EPA06222.1 - 0.088 12.8 0.2 0.17 11.8 0.1 1.5 1 1 0 1 1 1 0 Glutaredoxin GLTP PF08718.6 EPA06222.1 - 0.11 12.4 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) TrbC_Ftype PF09673.5 EPA06222.1 - 0.12 12.0 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein zinc_ribbon_2 PF13240.1 EPA06223.1 - 3.9e-06 26.1 4.3 6.1e-06 25.5 3.0 1.3 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.1 EPA06223.1 - 5.6e-05 22.1 5.6 9.1e-05 21.5 3.9 1.3 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.2 EPA06223.1 - 0.00013 21.7 2.2 0.00018 21.2 1.5 1.2 1 0 0 1 1 1 1 Double zinc ribbon PAH PF02671.16 EPA06223.1 - 0.032 13.8 0.1 0.062 12.9 0.1 1.5 1 0 0 1 1 1 0 Paired amphipathic helix repeat YkyA PF10368.4 EPA06223.1 - 0.044 13.1 0.5 0.054 12.8 0.3 1.1 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein Sipho_tail PF05709.6 EPA06223.1 - 0.046 12.8 0.1 0.06 12.4 0.1 1.1 1 0 0 1 1 1 0 Phage tail protein Nudix_N_2 PF14803.1 EPA06223.1 - 5.2 6.8 6.1 4.3 7.0 0.5 2.2 2 0 0 2 2 2 0 Nudix N-terminal Thioredoxin_3 PF13192.1 EPA06224.1 - 4.4e-11 42.4 0.1 4.4e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin domain Glutaredoxin PF00462.19 EPA06224.1 - 0.00043 20.2 0.1 0.00063 19.6 0.1 1.3 1 1 0 1 1 1 1 Glutaredoxin KaiB PF07689.7 EPA06224.1 - 0.00077 18.8 0.0 0.001 18.5 0.0 1.1 1 0 0 1 1 1 1 KaiB domain HTH_5 PF01022.15 EPA06225.1 - 3.3e-09 36.2 0.4 1e-08 34.6 0.1 1.8 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.1 EPA06225.1 - 8.5e-07 28.2 1.1 1.3e-06 27.6 0.8 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_20 PF12840.2 EPA06225.1 - 2.5e-06 27.1 0.0 6.3e-06 25.9 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain TrmB PF01978.14 EPA06225.1 - 8.7e-06 25.3 0.2 2e-05 24.1 0.0 1.6 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.7 EPA06225.1 - 0.00028 20.4 0.8 0.00036 20.1 0.1 1.5 2 0 0 2 2 2 1 HTH domain HTH_45 PF14947.1 EPA06225.1 - 0.0018 18.0 2.3 0.0024 17.6 1.6 1.4 1 1 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.17 EPA06225.1 - 0.0026 17.4 0.2 0.0053 16.4 0.2 1.5 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.1 EPA06225.1 - 0.0032 17.4 0.5 0.0044 17.0 0.1 1.4 2 0 0 2 2 1 1 Winged helix DNA-binding domain MarR_2 PF12802.2 EPA06225.1 - 0.0033 17.0 0.0 0.0065 16.1 0.0 1.5 1 1 1 2 2 2 1 MarR family B-block_TFIIIC PF04182.7 EPA06225.1 - 0.0043 16.8 0.2 0.0062 16.3 0.1 1.3 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC Phage_rep_org_N PF09681.5 EPA06225.1 - 0.0052 16.3 0.4 0.0055 16.2 0.3 1.1 1 0 0 1 1 1 1 N-terminal phage replisome organiser (Phage_rep_org_N) HTH_Crp_2 PF13545.1 EPA06225.1 - 0.013 15.2 0.1 0.21 11.3 0.0 2.1 1 1 1 2 2 2 0 Crp-like helix-turn-helix domain HTH_10 PF04967.7 EPA06225.1 - 0.032 13.7 0.1 0.096 12.2 0.0 1.7 2 0 0 2 2 2 0 HTH DNA binding domain HTH_12 PF08461.5 EPA06225.1 - 0.04 13.6 0.2 0.07 12.8 0.1 1.4 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain DUF4423 PF14394.1 EPA06225.1 - 0.069 12.6 0.6 0.22 11.0 0.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4423) Rib_5-P_isom_A PF06026.9 EPA06226.1 - 1.6e-51 174.0 0.2 2e-51 173.7 0.1 1.0 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.17 EPA06226.1 - 0.005 16.4 0.1 0.2 11.3 0.0 2.2 2 0 0 2 2 2 1 DeoR C terminal sensor domain Yqai PF09466.5 EPA06226.1 - 0.13 12.3 0.1 0.31 11.0 0.0 1.6 2 0 0 2 2 2 0 Hypothetical protein Yqai Ribosomal_L24e PF01246.15 EPA06227.1 - 3.5e-19 68.4 0.6 3.7e-19 68.3 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L24e DUF581 PF04570.9 EPA06227.1 - 0.028 13.6 0.2 0.048 12.9 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF581) zf-MYND PF01753.13 EPA06227.1 - 0.028 14.2 0.0 0.04 13.8 0.0 1.5 1 1 0 1 1 1 0 MYND finger DUF2256 PF10013.4 EPA06227.1 - 0.036 13.8 6.2 5.1 6.9 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-FCS PF06467.9 EPA06227.1 - 0.26 10.9 2.8 0.21 11.2 0.7 1.7 2 1 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif DUF329 PF03884.9 EPA06227.1 - 0.63 9.6 2.9 2.8 7.5 2.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF329) RNase_H PF00075.19 EPA06228.1 - 8.8e-17 61.6 0.0 1e-16 61.4 0.0 1.0 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.1 EPA06228.1 - 1.1e-10 41.1 0.0 1.4e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase-like Hex_IIIa PF02455.11 EPA06228.1 - 0.044 12.4 0.0 0.055 12.1 0.0 1.0 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) DUF1886 PF09171.5 EPA06228.1 - 0.079 11.9 0.1 0.48 9.4 0.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1886) DUF349 PF03993.7 EPA06228.1 - 0.12 12.4 0.4 0.34 11.0 0.3 1.8 1 1 0 1 1 1 0 Domain of Unknown Function (DUF349) Flagellin_C PF00700.16 EPA06229.1 - 0.032 14.3 0.2 0.2 11.8 0.1 2.4 1 1 1 2 2 2 0 Bacterial flagellin C-terminal helical region MTS_N PF08468.6 EPA06229.1 - 0.079 12.7 1.4 0.32 10.8 0.1 2.1 1 1 1 2 2 2 0 Methyltransferase small domain N-terminal SH3_1 PF00018.23 EPA06229.1 - 0.26 10.6 1.2 0.55 9.6 0.8 1.5 1 0 0 1 1 1 0 SH3 domain CCDC-167 PF15188.1 EPA06229.1 - 7.4 6.5 12.5 4.1 7.4 0.5 3.1 3 1 0 3 3 3 0 Coiled-coil domain-containing protein 167 PGM_PMM_I PF02878.11 EPA06230.1 - 4.7e-37 126.5 0.0 8.3e-37 125.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 EPA06230.1 - 2e-24 85.9 0.0 6.1e-24 84.3 0.0 1.8 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 EPA06230.1 - 9.1e-24 83.6 0.0 1.6e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.15 EPA06230.1 - 2.6e-09 36.9 0.0 6.8e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain RTX PF02382.10 EPA06230.1 - 0.014 13.6 0.0 0.15 10.2 0.0 2.0 2 0 0 2 2 2 0 RTX N-terminal domain Herpes_U59 PF04529.7 EPA06230.1 - 0.21 10.4 0.0 0.31 9.8 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus U59 protein ATP-grasp_5 PF13549.1 EPA06231.1 - 4.7e-79 264.6 0.8 8.8e-79 263.8 0.6 1.5 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.1 EPA06231.1 - 9.6e-52 174.2 0.8 2.9e-51 172.7 0.5 1.9 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 EPA06231.1 - 1e-21 77.2 0.4 3.1e-21 75.6 0.1 2.0 2 0 0 2 2 2 1 CoA binding domain CoA_binding PF02629.14 EPA06231.1 - 1.4e-09 38.3 3.6 3.6e-09 37.0 0.6 2.8 2 0 0 2 2 2 1 CoA binding domain ATP-grasp_4 PF13535.1 EPA06231.1 - 5e-05 23.1 0.0 0.00011 21.9 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_2 PF08442.5 EPA06231.1 - 5.2e-05 22.7 1.8 0.0001 21.7 1.3 1.6 1 0 0 1 1 1 1 ATP-grasp domain Dak1_2 PF13684.1 EPA06231.1 - 0.002 17.1 0.6 0.0056 15.6 0.2 1.9 1 1 1 2 2 2 1 Dihydroxyacetone kinase family CPSase_L_D2 PF02786.12 EPA06231.1 - 0.004 16.4 0.2 0.0073 15.6 0.2 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.17 EPA06231.1 - 0.064 12.5 0.2 0.2 10.9 0.1 1.9 1 1 0 1 1 1 0 ATP-grasp domain HTH_AsnC-type PF13404.1 EPA06233.1 - 5.5e-13 48.2 0.0 7.9e-13 47.7 0.0 1.3 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.1 EPA06233.1 - 4.2e-10 38.8 0.1 6.6e-10 38.2 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.14 EPA06233.1 - 2.4e-05 23.9 0.0 5.1e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Arc_trans_TRASH PF08394.5 EPA06233.1 - 5.8e-05 23.1 4.1 0.00011 22.3 2.8 1.5 1 0 0 1 1 1 1 Archaeal TRASH domain HTH_5 PF01022.15 EPA06233.1 - 0.0004 19.9 0.0 0.00075 19.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family DUF2250 PF10007.4 EPA06233.1 - 0.00079 19.2 1.5 0.037 13.9 0.0 2.2 1 1 1 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2250) HTH_Tnp_ISL3 PF13542.1 EPA06233.1 - 0.0021 17.2 0.0 0.0031 16.6 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.1 EPA06233.1 - 0.0033 17.3 0.1 0.028 14.4 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_9 PF08221.6 EPA06233.1 - 0.0043 16.8 0.0 0.0071 16.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_23 PF13384.1 EPA06233.1 - 0.012 15.2 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain ATPase-cat_bd PF12156.3 EPA06233.1 - 0.02 15.4 1.2 0.02 15.4 0.8 1.8 3 0 0 3 3 1 0 Putative metal-binding domain of cation transport ATPase HTH_38 PF13936.1 EPA06233.1 - 0.029 13.9 0.1 0.056 13.0 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4423 PF14394.1 EPA06233.1 - 0.037 13.5 0.1 0.084 12.4 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4423) MarR_2 PF12802.2 EPA06233.1 - 0.038 13.6 0.0 0.056 13.1 0.0 1.2 1 0 0 1 1 1 0 MarR family DUF2089 PF09862.4 EPA06233.1 - 0.058 13.1 0.9 0.48 10.2 0.6 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2089) Fe_dep_repress PF01325.14 EPA06233.1 - 0.059 13.3 0.2 0.15 11.9 0.0 1.7 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain Sigma70_r4_2 PF08281.7 EPA06233.1 - 0.072 12.5 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 zf-FCS PF06467.9 EPA06233.1 - 0.076 12.6 5.2 0.19 11.3 3.6 1.7 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif FeoC PF09012.5 EPA06233.1 - 0.089 12.5 0.0 0.089 12.5 0.0 2.3 2 1 1 3 3 3 0 FeoC like transcriptional regulator DUF1272 PF06906.6 EPA06233.1 - 0.097 12.5 1.1 0.17 11.7 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) NDK PF00334.14 EPA06234.1 - 1e-49 167.8 0.0 1.1e-49 167.6 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase He_PIG PF05345.7 EPA06235.1 - 5.8e-09 35.8 0.3 2.1e-08 34.0 0.2 2.0 1 0 0 1 1 1 1 Putative Ig domain Trypan_PARP PF05887.6 EPA06235.1 - 0.13 12.0 4.9 0.28 11.0 3.4 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) GTP_EFTU PF00009.22 EPA06236.1 - 7e-33 113.6 0.0 2.3e-32 111.9 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 EPA06236.1 - 7.9e-23 80.4 0.5 2.2e-22 78.9 0.4 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.1 EPA06236.1 - 2e-09 36.9 0.5 2e-09 36.9 0.3 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 EPA06236.1 - 3.9e-08 33.2 0.3 4.7e-07 29.7 0.0 2.7 3 0 0 3 3 3 1 50S ribosome-binding GTPase Miro PF08477.8 EPA06236.1 - 2.1e-06 28.1 0.0 9.9e-06 26.0 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein ATP_bind_1 PF03029.12 EPA06236.1 - 2.3e-05 24.0 0.0 0.00012 21.7 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Dynamin_N PF00350.18 EPA06236.1 - 0.00022 21.1 0.5 0.046 13.5 0.0 2.8 1 1 0 2 2 2 1 Dynamin family GTP_EFTU_D2 PF03144.20 EPA06236.1 - 0.0003 20.8 0.1 0.0014 18.6 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Ras PF00071.17 EPA06236.1 - 0.0014 18.0 0.1 0.025 13.9 0.0 2.7 2 1 0 2 2 2 1 Ras family cobW PF02492.14 EPA06236.1 - 0.011 15.2 1.3 1.1 8.7 0.1 2.8 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.5 EPA06236.1 - 0.018 14.2 0.1 0.077 12.2 0.0 2.2 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.4 EPA06236.1 - 0.058 12.8 0.6 0.81 9.1 0.0 3.0 3 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DUF475 PF04332.10 EPA06237.1 - 0.0029 17.2 4.5 0.0036 16.9 3.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF475) Tox-WTIP PF15654.1 EPA06237.1 - 0.054 13.1 0.2 0.17 11.5 0.0 1.8 2 0 0 2 2 2 0 Toxin with a conserved tryptophan and TIP tripeptide motif DUF3493 PF11998.3 EPA06237.1 - 0.06 13.2 0.5 0.13 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3493) Peptidase_C12 PF01088.16 EPA06237.1 - 0.14 11.2 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase, family 1 E1-N PF14463.1 EPA06237.1 - 0.15 11.6 0.1 0.28 10.7 0.1 1.4 1 0 0 1 1 1 0 E1 N-terminal domain DUF3270 PF11674.3 EPA06237.1 - 0.76 9.8 4.8 3 7.9 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) DUF1385 PF07136.6 EPA06237.1 - 1.5 7.8 5.9 3.1 6.8 3.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1385) DUF4199 PF13858.1 EPA06237.1 - 1.8 8.4 11.6 0.18 11.7 2.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) MreD PF04093.7 EPA06237.1 - 2.8 7.7 10.0 0.46 10.3 3.2 1.9 2 0 0 2 2 2 0 rod shape-determining protein MreD GtrA PF04138.9 EPA06237.1 - 3.2 7.7 8.9 0.31 11.0 0.5 2.6 2 1 1 3 3 3 0 GtrA-like protein Helitron_like_N PF14214.1 EPA06238.1 - 0.13 12.0 0.1 0.13 12.0 0.0 2.6 2 1 0 2 2 2 0 Helitron helicase-like domain at N-terminus Phe_tRNA-synt_N PF02912.13 EPA06238.1 - 0.16 11.7 2.8 24 4.7 0.1 3.7 3 0 0 3 3 3 0 Aminoacyl tRNA synthetase class II, N-terminal domain Fibrillarin PF01269.12 EPA06239.1 - 3.7e-86 287.7 0.2 4.4e-86 287.5 0.1 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 EPA06239.1 - 5.7e-05 22.7 0.0 8.2e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.14 EPA06239.1 - 0.0015 18.0 0.0 0.0027 17.2 0.0 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.12 EPA06239.1 - 0.023 13.7 0.0 0.12 11.3 0.0 2.0 1 1 1 2 2 2 0 Putative methyltransferase DUF4651 PF15513.1 EPA06239.1 - 0.027 13.8 0.0 0.06 12.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4651) FtsJ PF01728.14 EPA06240.1 - 1.8e-50 171.4 0.0 2.1e-50 171.2 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.1 EPA06240.1 - 2.6e-05 23.8 0.0 4.3e-05 23.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA06240.1 - 0.0059 16.3 0.0 0.012 15.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EPA06240.1 - 0.0069 15.9 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.1 EPA06240.1 - 0.013 15.8 0.0 0.026 14.8 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 EPA06240.1 - 0.035 14.6 0.0 0.065 13.8 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Nol1_Nop2_Fmu PF01189.12 EPA06240.1 - 0.037 13.4 0.0 0.19 11.1 0.0 1.8 2 0 0 2 2 2 0 NOL1/NOP2/sun family Ubie_methyltran PF01209.13 EPA06240.1 - 0.082 12.0 0.0 0.16 11.0 0.0 1.6 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family RNA_pol_Rpc34 PF05158.7 EPA06241.1 - 9.5e-06 25.0 1.7 2.2e-05 23.8 0.1 1.8 1 1 0 2 2 2 1 RNA polymerase Rpc34 subunit MarR PF01047.17 EPA06241.1 - 0.012 15.2 0.1 0.024 14.3 0.1 1.4 1 0 0 1 1 1 0 MarR family RPA_C PF08784.6 EPA06241.1 - 0.023 15.0 0.0 0.034 14.5 0.0 1.2 1 0 0 1 1 1 0 Replication protein A C terminal PYRIN PF02758.11 EPA06241.1 - 0.3 10.8 6.7 0.56 9.9 4.4 1.7 1 1 0 1 1 1 0 PAAD/DAPIN/Pyrin domain eIF-4B PF06273.6 EPA06241.1 - 0.39 9.4 2.6 0.44 9.2 1.8 1.0 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B RNase_HII PF01351.13 EPA06242.1 - 7e-44 149.8 0.2 8e-44 149.6 0.1 1.0 1 0 0 1 1 1 1 Ribonuclease HII TRM PF02005.11 EPA06243.1 - 2.3e-83 280.2 0.0 2.6e-83 280.0 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_31 PF13847.1 EPA06243.1 - 6.1e-05 22.6 0.1 0.0011 18.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.11 EPA06243.1 - 0.0022 17.6 0.0 0.0033 17.0 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein HTH_24 PF13412.1 EPA06243.1 - 0.0056 16.0 0.0 0.059 12.7 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Rrf2 PF02082.15 EPA06243.1 - 0.017 15.2 0.0 0.034 14.2 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator MarR PF01047.17 EPA06243.1 - 0.02 14.6 0.0 0.063 12.9 0.0 1.8 2 0 0 2 2 2 0 MarR family MTS PF05175.9 EPA06243.1 - 0.063 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain HTH_Mga PF08280.6 EPA06243.1 - 0.066 12.9 0.0 6.6 6.5 0.0 2.5 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain He_PIG PF05345.7 EPA06245.1 - 9.5e-05 22.3 1.2 9.5e-05 22.3 0.8 3.6 3 2 0 3 3 3 1 Putative Ig domain Trypan_PARP PF05887.6 EPA06245.1 - 0.0011 18.8 11.1 0.0016 18.2 7.7 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) fn3 PF00041.16 EPA06245.1 - 0.0047 17.0 6.8 0.067 13.3 0.9 2.5 2 1 0 2 2 2 2 Fibronectin type III domain DUF1034 PF06280.7 EPA06245.1 - 0.1 12.9 2.8 0.24 11.8 0.1 2.1 1 1 1 2 2 2 0 Fn3-like domain (DUF1034) DUF3944 PF13099.1 EPA06245.1 - 0.16 11.4 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) Cupredoxin_1 PF13473.1 EPA06245.1 - 0.17 11.7 0.8 11 5.9 0.1 2.2 1 1 1 2 2 2 0 Cupredoxin-like domain Neisseria_TspB PF05616.8 EPA06245.1 - 1.4 7.1 6.8 2 6.7 4.7 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein DUF95 PF01944.12 EPA06247.1 - 6.5e-07 29.1 19.8 8.2e-07 28.8 13.7 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF95 NIR_SIR_ferr PF03460.12 EPA06248.1 - 7e-17 60.8 0.0 1.1e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Thi4 PF01946.12 EPA06250.1 - 2.5e-64 216.5 0.1 3e-64 216.2 0.1 1.1 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.19 EPA06250.1 - 9.7e-14 51.0 0.3 8.8e-07 28.0 0.0 2.9 2 1 1 3 3 3 2 FAD binding domain FAD_oxidored PF12831.2 EPA06250.1 - 4.7e-10 39.1 0.0 6.9e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.19 EPA06250.1 - 3.8e-09 35.9 0.1 2.8e-05 23.1 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EPA06250.1 - 1.9e-07 31.0 0.0 4.1e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EPA06250.1 - 3.1e-07 30.4 0.0 5.1e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EPA06250.1 - 2.4e-06 26.2 0.0 3.5e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.14 EPA06250.1 - 2.9e-06 26.5 0.0 4.6e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.7 EPA06250.1 - 5.4e-05 22.2 0.1 0.0004 19.4 0.1 2.0 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.1 EPA06250.1 - 0.00021 21.4 0.1 0.00037 20.6 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EPA06250.1 - 0.00025 20.0 0.1 0.00041 19.3 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.9 EPA06250.1 - 0.0051 15.4 0.0 1 7.8 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_9 PF13454.1 EPA06250.1 - 0.01 15.6 0.1 0.02 14.6 0.1 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding Amino_oxidase PF01593.19 EPA06250.1 - 0.021 13.9 0.0 0.032 13.3 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase GDI PF00996.13 EPA06250.1 - 0.022 13.1 0.0 0.036 12.3 0.0 1.3 1 0 0 1 1 1 0 GDP dissociation inhibitor Pyr_redox PF00070.22 EPA06250.1 - 0.031 14.6 0.1 0.11 12.8 0.0 2.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase CPSase_L_chain PF00289.17 EPA06250.1 - 0.1 12.6 0.0 0.47 10.5 0.0 2.1 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, N-terminal domain NAD_binding_7 PF13241.1 EPA06250.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding Usp PF00582.21 EPA06251.1 - 2.3e-29 102.3 0.0 2.6e-29 102.2 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family Hydrolase PF00702.21 EPA06252.1 - 1.3e-10 42.1 0.3 2.1e-10 41.3 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EPA06252.1 - 0.00086 19.5 0.0 0.0017 18.5 0.0 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EPA06252.1 - 0.001 18.6 0.8 0.0014 18.2 0.5 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase MOFRL PF05161.8 EPA06253.1 - 0.00016 21.7 0.1 0.00016 21.7 0.0 1.0 1 0 0 1 1 1 1 MOFRL family DUF521 PF04412.8 EPA06254.1 - 9.7e-60 202.1 0.3 3.1e-59 200.5 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF521) Vps35 PF03635.12 EPA06256.1 - 0.0068 14.6 0.3 0.0074 14.5 0.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 HATPase_c PF02518.21 EPA06257.1 - 3.3e-23 81.5 0.0 7.1e-23 80.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.20 EPA06257.1 - 1.2e-11 44.5 0.0 7.1e-11 42.1 0.0 2.3 3 0 0 3 3 3 1 HAMP domain HATPase_c_5 PF14501.1 EPA06257.1 - 3e-10 39.7 0.8 4.5e-09 35.9 0.0 2.8 2 1 1 3 3 3 1 GHKL domain HisKA PF00512.20 EPA06257.1 - 5.1e-08 32.8 0.0 1.8e-07 31.0 0.0 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain 4HB_MCP_1 PF12729.2 EPA06257.1 - 0.00061 19.1 8.4 0.00061 19.1 5.8 3.0 3 1 0 3 3 3 1 Four helix bundle sensory module for signal transduction HATPase_c_3 PF13589.1 EPA06257.1 - 0.0029 17.2 0.1 0.02 14.5 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Syntaxin-6_N PF09177.6 EPA06257.1 - 0.5 10.8 4.1 4.9 7.6 0.1 3.5 4 0 0 4 4 4 0 Syntaxin 6, N-terminal GRA6 PF05084.8 EPA06258.1 - 0.078 12.4 6.7 0.081 12.4 4.6 1.1 1 0 0 1 1 1 0 Granule antigen protein (GRA6) Gly-zipper_OmpA PF13436.1 EPA06258.1 - 3.2 7.4 16.7 3.6 7.2 11.6 1.1 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Response_reg PF00072.19 EPA06259.1 - 6.4e-22 77.6 1.7 1.3e-21 76.7 0.5 2.0 2 0 0 2 2 2 1 Response regulator receiver domain TrmB PF01978.14 EPA06259.1 - 2e-14 53.0 0.0 6.1e-14 51.4 0.0 1.9 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.3 EPA06259.1 - 3.8e-05 22.7 1.2 6.3e-05 22.0 0.4 1.7 2 0 0 2 2 2 1 Archaeal transcriptional regulator TrmB DUF955 PF06114.8 EPA06260.1 - 0.091 12.4 0.3 0.18 11.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF955) Pirin PF02678.11 EPA06261.1 - 2e-37 127.3 0.2 3.6e-37 126.5 0.2 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.8 EPA06261.1 - 1.8e-32 111.5 0.2 7.2e-31 106.3 0.0 2.5 3 0 0 3 3 3 1 Pirin C-terminal cupin domain Cupin_2 PF07883.6 EPA06261.1 - 0.0015 17.9 2.0 0.46 10.0 0.2 3.0 3 0 0 3 3 3 2 Cupin domain VWA_2 PF13519.1 EPA06262.1 - 5.5e-26 91.6 0.1 9.9e-26 90.8 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 EPA06262.1 - 3.1e-24 85.6 1.7 3.1e-24 85.6 1.2 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 EPA06262.1 - 3.2e-06 27.1 0.0 7.1e-06 25.9 0.0 1.5 1 1 0 1 1 1 1 vWA found in TerF C terminus VWA_3 PF13768.1 EPA06262.1 - 0.0023 17.6 0.0 0.0041 16.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF1194 PF06707.6 EPA06262.1 - 0.11 11.4 0.1 1.5 7.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1194) DNAJ_related PF12339.3 EPA06263.1 - 0.068 13.0 0.4 0.072 12.9 0.3 1.1 1 0 0 1 1 1 0 DNA-J related protein IL2 PF00715.12 EPA06263.1 - 0.08 12.6 0.0 0.082 12.6 0.0 1.0 1 0 0 1 1 1 0 Interleukin 2 FMN_red PF03358.10 EPA06265.1 - 7.9e-42 142.3 0.0 9.5e-42 142.0 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 EPA06265.1 - 4.1e-09 36.2 0.0 5.4e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Pyr_redox PF00070.22 EPA06265.1 - 0.029 14.7 0.0 0.077 13.4 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HxlR PF01638.12 EPA06266.1 - 2.9e-25 87.7 1.5 3.5e-25 87.4 1.0 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_34 PF13601.1 EPA06266.1 - 0.05 13.6 0.1 0.07 13.1 0.1 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain MarR PF01047.17 EPA06266.1 - 0.097 12.3 0.1 0.24 11.1 0.1 1.6 1 0 0 1 1 1 0 MarR family Adenylsucc_synt PF00709.16 EPA06267.1 - 0.0041 15.8 0.5 0.0046 15.6 0.4 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Sec5 PF15469.1 EPA06267.1 - 0.046 13.4 1.2 0.055 13.2 0.8 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec5 ATP-synt_B PF00430.13 EPA06267.1 - 0.063 13.0 1.9 0.067 13.0 1.3 1.0 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) FlaC_arch PF05377.6 EPA06267.1 - 0.072 12.9 3.4 0.73 9.7 0.2 2.2 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Flu_NS2 PF00601.14 EPA06267.1 - 0.12 12.5 1.1 0.17 12.1 0.8 1.1 1 0 0 1 1 1 0 Influenza non-structural protein (NS2) IncA PF04156.9 EPA06267.1 - 0.21 11.1 1.1 0.27 10.8 0.7 1.2 1 0 0 1 1 1 0 IncA protein Seryl_tRNA_N PF02403.17 EPA06267.1 - 0.75 9.8 4.9 0.96 9.4 3.4 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain MscL PF01741.13 EPA06269.1 - 0.00039 20.5 1.0 0.00041 20.4 0.5 1.3 1 1 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL DUF456 PF04306.8 EPA06269.1 - 0.058 13.4 0.2 0.065 13.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF456) 7TM_GPCR_Srab PF10292.4 EPA06269.1 - 0.078 11.6 0.4 0.072 11.7 0.3 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR receptor class ab chemoreceptor Inhibitor_I71 PF12628.2 EPA06271.1 - 0.00024 20.8 0.2 0.00027 20.6 0.1 1.1 1 0 0 1 1 1 1 Falstatin, cysteine peptidase inhibitor UPF0302 PF08864.5 EPA06271.1 - 0.026 14.3 0.0 0.066 13.0 0.0 1.6 1 1 0 1 1 1 0 UPF0302 domain zinc_ribbon_2 PF13240.1 EPA06272.1 - 0.062 12.7 1.3 4.1 7.0 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.1 EPA06272.1 - 0.13 11.4 2.0 4 6.7 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Sgf11 PF08209.6 EPA06272.1 - 0.74 9.1 2.6 1.6 8.1 0.2 2.1 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) UvrC_HhH_N PF08459.6 EPA06275.1 - 4.8e-50 169.1 0.6 1.2e-48 164.5 0.0 2.1 2 0 0 2 2 2 2 UvrC Helix-hairpin-helix N-terminal UVR PF02151.14 EPA06275.1 - 1.8e-08 33.6 0.4 3.5e-08 32.6 0.3 1.5 1 0 0 1 1 1 1 UvrB/uvrC motif PcrB PF01884.12 EPA06276.1 - 1.2e-32 113.1 0.0 1.5e-32 112.7 0.0 1.0 1 0 0 1 1 1 1 PcrB family Gln-synt_C PF00120.19 EPA06277.1 - 6.7e-88 294.1 0.0 8.3e-88 293.8 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain TMEM238 PF15125.1 EPA06278.1 - 0.07 13.0 0.9 0.13 12.2 0.6 1.4 1 0 0 1 1 1 0 TMEM238 protein family DUF3792 PF12670.2 EPA06278.1 - 0.24 11.2 9.8 0.32 10.8 6.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) DUF2628 PF10947.3 EPA06278.1 - 0.44 10.3 3.6 0.66 9.8 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) DUF4492 PF14899.1 EPA06278.1 - 3.2 7.3 5.9 1.4 8.5 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4492) SHMT PF00464.14 EPA06279.1 - 2e-77 260.2 0.0 2.9e-77 259.7 0.0 1.2 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.16 EPA06279.1 - 1.3e-07 30.8 0.0 9e-07 28.1 0.0 2.2 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EPA06279.1 - 5.2e-05 22.5 0.0 0.00011 21.4 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase SelA PF03841.8 EPA06279.1 - 0.004 15.9 0.0 0.0064 15.2 0.0 1.3 1 0 0 1 1 1 1 L-seryl-tRNA selenium transferase Aminotran_5 PF00266.14 EPA06279.1 - 0.0058 15.4 0.1 0.0093 14.7 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Pyridoxal_deC PF00282.14 EPA06279.1 - 0.0081 14.6 0.0 0.021 13.2 0.0 1.6 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain FliH PF02108.11 EPA06280.1 - 0.033 14.0 0.3 0.081 12.8 0.0 1.7 2 1 0 2 2 2 0 Flagellar assembly protein FliH G-alpha PF00503.15 EPA06280.1 - 0.095 11.3 0.5 0.14 10.7 0.3 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA PF00004.24 EPA06281.1 - 1e-11 45.1 1.5 4.4e-11 43.0 0.4 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EPA06281.1 - 1.2e-11 44.8 0.0 2.4e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EPA06281.1 - 2.3e-09 37.5 0.2 2.1e-08 34.3 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain NACHT PF05729.7 EPA06281.1 - 4.3e-07 29.7 0.0 6e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 NACHT domain Arch_ATPase PF01637.13 EPA06281.1 - 2.6e-06 27.3 3.3 6.6e-06 25.9 1.7 2.1 1 1 0 1 1 1 1 Archaeal ATPase DUF2075 PF09848.4 EPA06281.1 - 6.3e-05 22.1 0.0 8.7e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.9 EPA06281.1 - 0.00017 20.6 0.1 0.00041 19.3 0.0 1.6 2 0 0 2 2 2 1 PIF1-like helicase KAP_NTPase PF07693.9 EPA06281.1 - 0.00019 20.5 0.2 0.42 9.5 0.0 2.3 2 0 0 2 2 2 2 KAP family P-loop domain NB-ARC PF00931.17 EPA06281.1 - 0.00024 20.0 0.1 0.0004 19.3 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_5 PF07728.9 EPA06281.1 - 0.00024 20.8 0.1 0.0008 19.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.8 EPA06281.1 - 0.00049 19.0 0.0 0.0013 17.7 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_32 PF13654.1 EPA06281.1 - 0.00076 18.2 0.5 0.041 12.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain KaiC PF06745.8 EPA06281.1 - 0.00086 18.4 0.5 0.29 10.2 0.0 2.6 2 1 0 2 2 2 1 KaiC RNA_helicase PF00910.17 EPA06281.1 - 0.0024 18.0 0.0 0.0064 16.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_19 PF13245.1 EPA06281.1 - 0.0025 17.5 0.0 0.0068 16.1 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain T2SE PF00437.15 EPA06281.1 - 0.0027 16.6 0.0 0.0059 15.5 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein TrwB_AAD_bind PF10412.4 EPA06281.1 - 0.0044 15.6 0.0 0.015 13.9 0.0 1.8 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_24 PF13479.1 EPA06281.1 - 0.0063 16.1 0.2 0.016 14.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.10 EPA06281.1 - 0.017 14.8 2.3 0.39 10.4 1.6 2.4 1 1 0 1 1 1 0 NTPase Mg_chelatase PF01078.16 EPA06281.1 - 0.022 13.9 0.0 0.05 12.7 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ResIII PF04851.10 EPA06281.1 - 0.024 14.4 0.1 0.33 10.7 0.0 2.3 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_11 PF13086.1 EPA06281.1 - 0.027 14.0 2.3 0.074 12.6 1.6 1.8 1 1 0 1 1 1 0 AAA domain Cdc6_C PF09079.6 EPA06281.1 - 0.038 13.6 0.1 0.22 11.2 0.0 2.2 2 0 0 2 2 2 0 CDC6, C terminal Sigma54_activat PF00158.21 EPA06281.1 - 0.065 12.7 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.12 EPA06281.1 - 0.12 11.8 0.4 2.8 7.3 0.0 2.8 3 1 1 4 4 4 0 IstB-like ATP binding protein Tbf5 PF06331.7 EPA06281.1 - 0.19 11.4 2.8 14 5.5 0.1 3.2 3 0 0 3 3 3 0 Transcription factor TFIIH complex subunit Tfb5 Zot PF05707.7 EPA06281.1 - 0.31 10.4 1.8 1.5 8.2 0.2 2.8 3 1 0 3 3 3 0 Zonular occludens toxin (Zot) HTH_27 PF13463.1 EPA06282.1 - 7.4e-07 29.4 0.1 1.3e-06 28.6 0.1 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.14 EPA06282.1 - 2.8e-05 23.7 0.2 6e-05 22.6 0.0 1.6 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB DUF3116 PF11313.3 EPA06282.1 - 0.00027 20.4 0.8 0.00057 19.4 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3116) HTH_34 PF13601.1 EPA06282.1 - 0.001 19.0 1.2 0.0015 18.5 0.2 1.7 2 0 0 2 2 2 1 Winged helix DNA-binding domain Replic_Relax PF13814.1 EPA06282.1 - 0.005 16.7 0.1 0.0099 15.7 0.1 1.5 1 0 0 1 1 1 1 Replication-relaxation MarR PF01047.17 EPA06282.1 - 0.0074 15.9 0.1 0.018 14.7 0.1 1.6 1 0 0 1 1 1 1 MarR family HTH_45 PF14947.1 EPA06282.1 - 0.015 15.1 2.8 0.02 14.7 0.5 2.2 2 1 1 3 3 3 0 Winged helix-turn-helix pRN1_helical PF13010.1 EPA06282.1 - 0.018 14.6 0.4 0.028 14.0 0.3 1.3 1 0 0 1 1 1 0 Primase helical domain HTH_24 PF13412.1 EPA06282.1 - 0.07 12.5 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 EPA06282.1 - 0.077 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 MarR family LAGLIDADG_1 PF00961.14 EPA06282.1 - 0.51 10.9 3.3 0.48 10.9 0.5 2.1 1 1 1 2 2 2 0 LAGLIDADG endonuclease ArsC PF03960.10 EPA06282.1 - 0.8 9.8 5.0 5 7.2 1.3 2.3 1 1 1 2 2 2 0 ArsC family PolC_DP2 PF03833.8 EPA06283.1 - 4.7e-109 365.4 2.9 4.3e-108 362.2 2.0 1.9 1 1 0 1 1 1 1 DNA polymerase II large subunit DP2 PolC_DP2 PF03833.8 EPA06284.1 - 3.2e-149 498.3 0.0 3.9e-149 498.0 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase II large subunit DP2 PcrB PF01884.12 EPA06285.1 - 6.4e-08 32.1 0.1 7.2e-08 31.9 0.1 1.0 1 0 0 1 1 1 1 PcrB family His_biosynth PF00977.16 EPA06285.1 - 0.0018 17.5 0.0 0.0019 17.4 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Penicillinase_R PF03965.11 EPA06286.1 - 0.0032 17.5 0.0 0.0049 16.9 0.0 1.3 1 0 0 1 1 1 1 Penicillinase repressor Antitoxin-MazE PF04014.13 EPA06287.1 - 1.8e-07 30.7 0.2 2.1e-07 30.4 0.1 1.1 1 0 0 1 1 1 1 Antidote-toxin recognition MazE MraZ PF02381.13 EPA06287.1 - 0.14 11.9 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 MraZ protein Cpn60_TCP1 PF00118.19 EPA06288.1 - 2.8e-169 563.8 18.7 3.2e-169 563.6 13.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ustilago_mating PF05722.7 EPA06288.1 - 0.04 13.2 0.0 0.09 12.0 0.0 1.5 1 0 0 1 1 1 0 Ustilago B locus mating-type protein LSM PF01423.17 EPA06289.1 - 1.2e-09 37.5 0.3 1.2e-09 37.5 0.2 1.0 1 0 0 1 1 1 1 LSM domain S-AdoMet_synt_N PF00438.15 EPA06290.1 - 2.6e-42 143.0 0.2 3.2e-42 142.8 0.2 1.1 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.11 EPA06290.1 - 1.4e-09 37.8 1.0 1.4e-07 31.5 0.1 2.2 2 0 0 2 2 2 2 S-adenosylmethionine synthetase, central domain AdoMet_Synthase PF01941.14 EPA06290.1 - 0.0056 15.2 0.4 0.79 8.1 0.0 2.0 1 1 1 2 2 2 2 S-adenosylmethionine synthetase (AdoMet synthetase) Rad51 PF08423.6 EPA06291.1 - 1.1e-08 34.3 0.2 1.1e-08 34.3 0.1 1.0 1 0 0 1 1 1 1 Rad51 KaiC PF06745.8 EPA06291.1 - 1.2e-08 34.4 0.7 1.3e-08 34.2 0.5 1.0 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.1 EPA06291.1 - 1.9e-07 30.6 0.0 2e-07 30.5 0.0 1.0 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 EPA06291.1 - 3.7e-06 26.2 0.1 3.7e-06 26.2 0.0 1.0 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ABC_tran PF00005.22 EPA06291.1 - 0.00053 20.3 0.1 0.00057 20.2 0.1 1.0 1 0 0 1 1 1 1 ABC transporter Arch_ATPase PF01637.13 EPA06291.1 - 0.003 17.2 0.0 0.003 17.2 0.0 1.0 1 0 0 1 1 1 1 Archaeal ATPase IstB_IS21 PF01695.12 EPA06291.1 - 0.0043 16.4 0.0 0.0043 16.4 0.0 1.1 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.1 EPA06291.1 - 0.021 14.3 0.1 0.024 14.2 0.1 1.1 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.16 EPA06291.1 - 0.062 12.5 0.0 0.067 12.4 0.0 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain NB-ARC PF00931.17 EPA06291.1 - 0.065 12.0 0.1 0.07 11.9 0.0 1.0 1 0 0 1 1 1 0 NB-ARC domain PhoH PF02562.11 EPA06291.1 - 0.074 12.2 0.0 0.077 12.2 0.0 1.1 1 0 0 1 1 1 0 PhoH-like protein AAA_10 PF12846.2 EPA06291.1 - 0.083 12.3 0.1 0.14 11.6 0.0 1.4 1 1 1 2 2 2 0 AAA-like domain AAA_19 PF13245.1 EPA06291.1 - 0.087 12.5 0.1 0.092 12.5 0.1 1.1 1 0 0 1 1 1 0 Part of AAA domain AAA_16 PF13191.1 EPA06291.1 - 0.11 12.4 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain TrwB_AAD_bind PF10412.4 EPA06291.1 - 0.12 10.9 0.1 0.13 10.8 0.1 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain DAP3 PF10236.4 EPA06291.1 - 0.12 11.2 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.17 EPA06291.1 - 0.14 12.3 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 RNA helicase Rad51 PF08423.6 EPA06293.1 - 3.2e-11 42.6 0.2 3.8e-11 42.4 0.1 1.1 1 0 0 1 1 1 1 Rad51 VPEP PF07589.6 EPA06294.1 - 0.1 12.5 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 PEP-CTERM motif TIM21 PF08294.6 EPA06294.1 - 0.13 11.9 0.1 0.13 11.9 0.1 1.0 1 0 0 1 1 1 0 TIM21 Rad51 PF08423.6 EPA06295.1 - 7.8e-13 47.9 0.1 9.5e-13 47.6 0.1 1.1 1 0 0 1 1 1 1 Rad51 VPEP PF07589.6 EPA06297.1 - 0.12 12.2 0.1 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 PEP-CTERM motif DUF2019 PF09450.5 EPA06298.1 - 0.088 12.6 0.2 0.098 12.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2019) SBP_bac_5 PF00496.17 EPA06299.1 - 1.1e-15 57.3 0.0 1.4e-15 57.0 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle SBP_bac_5 PF00496.17 EPA06301.1 - 1.2e-15 57.2 0.0 1.4e-15 57.0 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle NAD_binding_2 PF03446.10 EPA06302.1 - 1.6e-05 24.8 0.0 1.6e-05 24.8 0.0 1.0 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.11 EPA06302.1 - 1.9e-05 24.1 0.0 2.1e-05 23.9 0.0 1.0 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.13 EPA06302.1 - 0.00095 19.1 0.0 0.001 19.0 0.0 1.0 1 0 0 1 1 1 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.9 EPA06302.1 - 0.0021 17.4 0.0 0.0022 17.3 0.0 1.0 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.14 EPA06302.1 - 0.0022 17.1 0.0 0.0022 17.1 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.12 EPA06302.1 - 0.0086 16.4 0.0 0.0086 16.4 0.0 1.0 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_10 PF13460.1 EPA06302.1 - 0.011 15.7 0.0 0.011 15.7 0.0 1.0 1 0 0 1 1 1 0 NADH(P)-binding NAD_Gly3P_dh_N PF01210.18 EPA06302.1 - 0.019 14.7 0.0 0.02 14.6 0.0 1.0 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.13 EPA06302.1 - 0.063 12.9 0.0 0.063 12.9 0.0 1.0 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.1 EPA06302.1 - 0.089 12.8 0.0 0.1 12.6 0.0 1.1 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EPA06302.1 - 0.089 11.6 0.0 0.089 11.6 0.0 1.0 1 0 0 1 1 1 0 FAD dependent oxidoreductase Nitroreductase PF00881.19 EPA06303.1 - 7.3e-35 120.2 0.0 1.1e-34 119.6 0.0 1.3 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.1 EPA06303.1 - 0.0048 16.1 0.0 0.0097 15.1 0.0 1.6 2 0 0 2 2 2 1 Putative TM nitroreductase zf-ribbon_3 PF13248.1 EPA06304.1 - 0.0038 16.3 1.9 0.34 10.1 0.1 2.7 2 1 0 2 2 2 1 zinc-ribbon domain zf-dskA_traR PF01258.12 EPA06304.1 - 0.0062 16.2 3.4 0.07 12.8 0.3 2.3 2 0 0 2 2 2 1 Prokaryotic dksA/traR C4-type zinc finger DZR PF12773.2 EPA06304.1 - 0.016 15.0 7.9 0.11 12.3 5.5 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-DHHC PF01529.15 EPA06304.1 - 0.025 13.9 2.2 0.031 13.6 1.5 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF983 PF06170.7 EPA06304.1 - 0.16 12.0 1.0 1.9 8.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF983) DUF1610 PF07754.6 EPA06304.1 - 0.24 11.5 4.3 1.4 9.1 3.0 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF1610) Tnp_zf-ribbon_2 PF13842.1 EPA06304.1 - 0.49 10.8 7.1 1.7 9.0 1.2 3.0 2 1 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon zinc_ribbon_2 PF13240.1 EPA06304.1 - 0.52 9.8 7.4 0.93 9.0 0.5 2.6 2 1 0 2 2 2 0 zinc-ribbon domain DUF2039 PF10217.4 EPA06304.1 - 0.6 10.1 5.3 0.62 10.1 2.8 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) RNA_POL_M_15KD PF02150.11 EPA06304.1 - 0.62 9.8 8.1 0.18 11.5 2.4 2.4 2 1 0 2 2 2 0 RNA polymerases M/15 Kd subunit zf-NADH-PPase PF09297.6 EPA06304.1 - 1.2 8.7 5.8 1.4 8.4 0.1 2.7 2 1 1 3 3 3 0 NADH pyrophosphatase zinc ribbon domain HypA PF01155.14 EPA06304.1 - 1.7 8.3 6.7 0.35 10.5 2.3 1.5 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Stc1 PF12898.2 EPA06304.1 - 2.3 8.3 6.9 20 5.2 4.8 2.1 1 1 0 1 1 1 0 Stc1 domain zf-CHY PF05495.7 EPA06304.1 - 2.4 8.3 6.8 5.2 7.2 4.7 1.6 1 1 0 1 1 1 0 CHY zinc finger OrfB_Zn_ribbon PF07282.6 EPA06304.1 - 3.3 7.4 7.0 1.4 8.6 0.7 2.1 1 1 1 2 2 2 0 Putative transposase DNA-binding domain Methyltransf_31 PF13847.1 EPA06305.1 - 3.9e-18 65.4 0.4 4.9e-18 65.1 0.3 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA06305.1 - 2.7e-15 56.6 0.0 3.6e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA06305.1 - 5.3e-15 55.9 0.0 6.8e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EPA06305.1 - 1.2e-13 50.7 0.0 1.3e-13 50.6 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EPA06305.1 - 5.7e-13 49.0 0.0 1.1e-12 48.2 0.0 1.4 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA06305.1 - 2.9e-12 46.9 0.1 4.8e-12 46.2 0.0 1.4 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA06305.1 - 2.7e-09 36.9 0.0 3.5e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EPA06305.1 - 1.2e-08 34.5 0.0 3.1e-08 33.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 EPA06305.1 - 1.9e-07 30.5 0.1 2.4e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 EPA06305.1 - 2.2e-07 30.9 0.0 3.4e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 EPA06305.1 - 4.6e-06 26.1 0.0 5.7e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) TehB PF03848.9 EPA06305.1 - 4.4e-05 22.7 0.0 5.7e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_9 PF08003.6 EPA06305.1 - 0.0002 20.1 0.0 0.00022 20.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) RrnaAD PF00398.15 EPA06305.1 - 0.0012 17.9 0.0 0.0014 17.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase CMAS PF02353.15 EPA06305.1 - 0.0015 17.6 0.0 0.002 17.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.1 EPA06305.1 - 0.0085 16.9 0.0 0.013 16.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.10 EPA06305.1 - 0.026 13.6 0.0 0.037 13.1 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_32 PF13679.1 EPA06305.1 - 0.049 13.3 0.0 0.065 12.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 EPA06305.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PCMT PF01135.14 EPA06305.1 - 0.15 11.5 0.1 0.25 10.8 0.0 1.5 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CPSase_L_D2 PF02786.12 EPA06306.1 - 1.8e-27 95.9 0.0 2.6e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.14 EPA06306.1 - 7.5e-25 87.0 0.0 1.9e-24 85.7 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 EPA06306.1 - 2.5e-18 66.4 0.0 6.6e-18 65.0 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_chain PF00289.17 EPA06306.1 - 4.6e-16 58.8 0.0 1.1e-15 57.7 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain MGS PF02142.17 EPA06306.1 - 2.2e-14 53.1 0.3 3.4e-13 49.3 0.0 2.6 2 0 0 2 2 2 1 MGS-like domain ATPgrasp_Ter PF15632.1 EPA06306.1 - 6.1e-14 51.5 0.1 4.5e-13 48.6 0.0 2.2 2 1 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 EPA06306.1 - 3.3e-09 36.3 0.0 5.6e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EPA06306.1 - 2.6e-08 33.4 0.0 5.5e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus GARS_A PF01071.14 EPA06306.1 - 5.3e-05 22.8 0.0 0.00019 21.0 0.0 1.9 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.6 EPA06306.1 - 0.0014 18.1 0.1 0.0039 16.6 0.1 1.8 1 1 0 1 1 1 1 RimK-like ATP-grasp domain TrkA_N PF02254.13 EPA06306.1 - 0.0031 17.4 0.0 0.012 15.5 0.0 2.0 1 0 0 1 1 1 1 TrkA-N domain ATP-grasp_3 PF02655.9 EPA06306.1 - 0.014 15.2 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain DUF327 PF03885.8 EPA06307.1 - 0.023 14.5 1.9 0.024 14.4 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF327) Poty_coat PF00767.13 EPA06307.1 - 0.11 11.7 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Potyvirus coat protein DUF2407_C PF13373.1 EPA06308.1 - 0.0077 16.1 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF4520 PF15016.1 EPA06308.1 - 0.15 11.6 0.1 11 5.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4520) YjgF_endoribonc PF14588.1 EPA06309.1 - 5.8e-33 113.9 0.0 6.3e-33 113.7 0.0 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.16 EPA06309.1 - 3e-21 75.4 0.0 3.7e-21 75.1 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP BON PF04972.12 EPA06309.1 - 0.051 13.3 0.0 0.3 10.8 0.0 2.1 2 0 0 2 2 2 0 BON domain TrmB PF01978.14 EPA06310.1 - 1.1e-17 63.4 0.4 9.5e-17 60.4 0.1 2.4 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.3 EPA06310.1 - 8.2e-06 24.9 0.2 1.3e-05 24.2 0.2 1.3 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB DUF327 PF03885.8 EPA06310.1 - 0.036 13.8 0.5 0.036 13.8 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF327) ATP-synt_F PF01990.12 EPA06311.1 - 3.6e-15 56.1 0.0 4e-15 55.9 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit Trp_syntA PF00290.15 EPA06311.1 - 0.00021 19.8 0.0 0.00021 19.8 0.0 1.0 1 0 0 1 1 1 1 Tryptophan synthase alpha chain GTP-bdg_N PF13167.1 EPA06311.1 - 0.04 14.0 0.2 0.059 13.4 0.1 1.2 1 0 0 1 1 1 0 GTP-binding GTPase N-terminal DUF4350 PF14258.1 EPA06311.1 - 0.079 13.1 0.1 0.31 11.2 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4350) UBA_3 PF09288.5 EPA06312.1 - 0.013 15.1 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Herpes_U55 PF06501.6 EPA06312.1 - 0.032 12.8 0.0 0.032 12.8 0.0 1.0 1 0 0 1 1 1 0 Human herpesvirus U55 protein CPSase_L_D2 PF02786.12 EPA06314.1 - 9.9e-72 240.6 0.2 1.3e-71 240.2 0.1 1.1 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.1 EPA06314.1 - 7.2e-16 58.4 0.0 9.6e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D3 PF02787.14 EPA06314.1 - 1.5e-08 34.4 0.0 3.7e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.17 EPA06314.1 - 3.7e-07 29.6 0.1 5.5e-07 29.0 0.1 1.2 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EPA06314.1 - 4.8e-05 22.8 0.3 0.00011 21.6 0.2 1.6 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.1 EPA06314.1 - 5.1e-05 22.1 0.0 0.0015 17.3 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon GARS_A PF01071.14 EPA06314.1 - 0.01 15.4 0.1 0.017 14.6 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_2 PF08442.5 EPA06314.1 - 0.04 13.2 0.1 0.1 11.9 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_3 PF02655.9 EPA06314.1 - 0.047 13.5 0.4 0.068 13.0 0.3 1.3 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_5 PF13549.1 EPA06314.1 - 0.086 12.0 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain ADH_N PF08240.7 EPA06315.1 - 1.1e-24 86.2 2.2 1.8e-24 85.5 1.1 1.6 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain DDE_5 PF13546.1 EPA06315.1 - 0.075 11.8 0.0 0.64 8.8 0.0 2.0 2 0 0 2 2 2 0 DDE superfamily endonuclease CPSase_sm_chain PF00988.17 EPA06316.1 - 1.9e-43 147.0 0.0 6.8e-43 145.3 0.0 1.9 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 EPA06316.1 - 8.9e-42 142.7 0.1 1.3e-41 142.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EPA06316.1 - 2.2e-08 33.7 0.2 7.4e-07 28.8 0.1 2.3 1 1 0 1 1 1 1 Peptidase C26 DUF3867 PF12983.2 EPA06316.1 - 0.053 13.5 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3867) DHHA1 PF02272.14 EPA06318.1 - 6.5e-12 44.9 1.6 1.4e-11 43.8 0.1 2.2 3 0 0 3 3 3 1 DHHA1 domain DHH PF01368.15 EPA06318.1 - 0.0019 17.8 4.6 0.0038 16.8 2.5 2.0 2 1 0 2 2 2 1 DHH family DeoC PF01791.4 EPA06319.1 - 1.7e-05 24.2 0.0 2.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 DeoC/LacD family aldolase ThiG PF05690.9 EPA06319.1 - 0.011 14.7 0.1 0.013 14.6 0.0 1.0 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG DUF561 PF04481.7 EPA06319.1 - 0.045 12.7 0.0 0.049 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF561) Citrate_synt PF00285.16 EPA06320.1 - 9.3e-139 462.0 0.0 1e-138 461.9 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase DUF1940 PF09155.5 EPA06320.1 - 0.0021 17.9 0.0 0.025 14.4 0.0 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF1940) FrhB_FdhB_N PF04422.8 EPA06320.1 - 0.046 13.5 0.1 0.1 12.4 0.1 1.7 1 1 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term Imm47 PF15586.1 EPA06320.1 - 0.091 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 47 Metallophos PF00149.23 EPA06322.1 - 4.6e-09 35.9 0.7 2.6e-07 30.2 0.0 2.2 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EPA06322.1 - 3.2e-06 27.0 0.2 6.9e-06 25.9 0.1 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.1 EPA06322.1 - 0.0046 16.1 0.1 0.32 10.0 0.1 2.1 1 1 0 1 1 1 1 Metallophosphoesterase, calcineurin superfamily Epimerase_2 PF02350.14 EPA06322.1 - 0.028 13.1 0.0 0.052 12.3 0.0 1.4 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase DNA_pol_E_B PF04042.11 EPA06322.1 - 0.037 13.2 0.1 0.12 11.5 0.0 1.9 2 1 0 2 2 2 0 DNA polymerase alpha/epsilon subunit B DUF2439 PF10382.4 EPA06323.1 - 0.085 13.0 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2439) ADH_zinc_N PF00107.21 EPA06324.1 - 5.2e-16 58.3 0.0 6.9e-16 57.9 0.0 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EPA06324.1 - 5.5e-05 24.0 0.0 6.7e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DASH_Spc19 PF08287.6 EPA06325.1 - 0.013 15.1 0.5 0.013 15.1 0.3 1.7 2 1 0 2 2 2 0 Spc19 Nol1_Nop2_Fmu_2 PF13636.1 EPA06326.1 - 0.028 14.5 0.0 0.04 13.9 0.0 1.3 1 1 0 1 1 1 0 pre-rRNA processing and ribosome biogenesis SWIM PF04434.12 EPA06326.1 - 0.081 12.4 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 SWIM zinc finger DeoC PF01791.4 EPA06327.1 - 3.1e-13 49.5 0.0 3.6e-13 49.3 0.0 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase CPSase_L_chain PF00289.17 EPA06328.1 - 1.3e-06 28.4 0.0 1.6e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain AAA PF00004.24 EPA06329.1 - 9.8e-38 129.3 0.0 2.3e-37 128.1 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.13 EPA06329.1 - 3.8e-08 33.0 0.3 1.5e-07 31.1 0.1 2.0 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain AAA_2 PF07724.9 EPA06329.1 - 2e-07 31.0 0.0 4.1e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 EPA06329.1 - 5.6e-06 26.5 0.0 2.7e-05 24.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EPA06329.1 - 1e-05 24.6 0.0 2.8e-05 23.2 0.0 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Vps4_C PF09336.5 EPA06329.1 - 2.2e-05 24.2 0.0 0.00012 21.9 0.0 2.1 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Zeta_toxin PF06414.7 EPA06329.1 - 3.8e-05 22.8 0.0 0.0001 21.5 0.0 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_24 PF13479.1 EPA06329.1 - 0.00015 21.4 0.0 0.00032 20.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EPA06329.1 - 0.00035 20.4 0.0 0.0023 17.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 EPA06329.1 - 0.00039 19.8 0.2 0.003 16.9 0.1 2.0 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 EPA06329.1 - 0.00071 19.6 0.0 0.033 14.1 0.0 2.7 1 1 1 3 3 3 1 AAA ATPase domain AAA_33 PF13671.1 EPA06329.1 - 0.0011 18.8 0.0 0.003 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 EPA06329.1 - 0.0018 17.9 0.0 2.5 7.7 0.0 2.7 1 1 1 2 2 2 2 Archaeal ATPase AAA_17 PF13207.1 EPA06329.1 - 0.0027 18.5 0.0 0.0071 17.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EPA06329.1 - 0.0034 17.1 0.1 0.015 15.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 EPA06329.1 - 0.004 16.3 0.1 0.0091 15.1 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 EPA06329.1 - 0.0052 16.2 0.0 0.0097 15.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 EPA06329.1 - 0.0061 16.2 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain TIP49 PF06068.8 EPA06329.1 - 0.0077 14.9 0.0 0.013 14.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_11 PF13086.1 EPA06329.1 - 0.0077 15.8 0.0 0.028 13.9 0.0 1.8 1 1 1 2 2 2 1 AAA domain KAP_NTPase PF07693.9 EPA06329.1 - 0.011 14.7 0.0 0.3 10.0 0.0 2.1 1 1 1 2 2 2 0 KAP family P-loop domain AAA_18 PF13238.1 EPA06329.1 - 0.039 14.2 0.2 0.14 12.4 0.0 2.2 2 1 0 2 2 1 0 AAA domain KaiC PF06745.8 EPA06329.1 - 0.046 12.8 0.1 1.7 7.6 0.0 2.2 1 1 1 2 2 2 0 KaiC Parvo_NS1 PF01057.12 EPA06329.1 - 0.089 11.6 0.0 0.21 10.4 0.0 1.7 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 PhoH PF02562.11 EPA06329.1 - 0.091 11.9 0.2 0.23 10.6 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein RNA_helicase PF00910.17 EPA06329.1 - 0.099 12.8 0.0 0.34 11.1 0.0 2.0 1 0 0 1 1 1 0 RNA helicase ResIII PF04851.10 EPA06329.1 - 0.11 12.3 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NACHT PF05729.7 EPA06329.1 - 0.14 11.8 0.2 0.39 10.3 0.0 1.8 2 0 0 2 2 1 0 NACHT domain TruD PF01142.13 EPA06330.1 - 1.8e-26 92.7 0.0 2.1e-26 92.5 0.0 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) Response_reg PF00072.19 EPA06331.1 - 1.2e-16 60.6 0.0 1.6e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Arch_flagellin PF01917.11 EPA06332.1 - 4.1e-17 62.4 5.7 6.1e-17 61.8 4.0 1.3 1 1 0 1 1 1 1 Archaebacterial flagellin Peptidase_M10 PF00413.19 EPA06333.1 - 1.8e-09 37.4 0.0 1.9e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Matrixin Peptidase_M57 PF12388.3 EPA06333.1 - 2.4e-06 27.0 0.3 2.2e-05 23.8 0.1 2.0 2 0 0 2 2 2 1 Dual-action HEIGH metallo-peptidase Reprolysin_2 PF13574.1 EPA06333.1 - 0.011 15.8 0.2 0.028 14.4 0.2 1.7 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.4 EPA06333.1 - 0.013 14.4 0.0 0.028 13.2 0.0 1.5 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_3 PF13582.1 EPA06333.1 - 0.054 14.0 0.0 0.079 13.4 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M64 PF09471.5 EPA06333.1 - 0.13 11.8 0.1 0.23 11.0 0.1 1.3 1 0 0 1 1 1 0 IgA Peptidase M64 Reprolysin_4 PF13583.1 EPA06333.1 - 0.19 11.2 1.5 0.53 9.7 1.1 1.7 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Arch_flagellin PF01917.11 EPA06334.1 - 2.5e-18 66.3 7.6 4.4e-18 65.5 5.3 1.4 1 1 0 1 1 1 1 Archaebacterial flagellin DUF1628 PF07790.6 EPA06334.1 - 0.92 10.3 5.7 1.8 9.3 4.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1628) HATPase_c PF02518.21 EPA06335.1 - 7.4e-20 70.7 0.4 1.9e-19 69.4 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EPA06335.1 - 8.7e-09 35.2 0.6 1.8e-08 34.2 0.4 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.1 EPA06335.1 - 1.5e-08 34.2 2.3 1.7e-08 34.0 0.6 1.8 1 1 1 2 2 2 1 GHKL domain HATPase_c_3 PF13589.1 EPA06335.1 - 5.1e-05 22.9 0.1 0.00015 21.4 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 EPA06335.1 - 0.017 14.8 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain GAS PF13851.1 EPA06336.1 - 0.015 14.5 0.6 0.015 14.5 0.4 2.7 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.6 EPA06336.1 - 0.024 14.5 0.2 0.024 14.5 0.1 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF4322 PF14210.1 EPA06336.1 - 0.037 13.5 1.7 0.11 12.0 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4322) DUF2388 PF09498.5 EPA06336.1 - 0.063 12.9 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) Reo_sigmaC PF04582.7 EPA06336.1 - 0.065 12.3 2.4 0.049 12.8 0.6 1.4 1 1 0 1 1 1 0 Reovirus sigma C capsid protein DivIC PF04977.10 EPA06336.1 - 0.17 11.3 2.2 2.1 7.8 0.3 2.5 3 0 0 3 3 3 0 Septum formation initiator IncA PF04156.9 EPA06336.1 - 0.22 11.0 2.6 0.3 10.6 0.2 1.9 1 1 1 2 2 2 0 IncA protein Prefoldin_3 PF13758.1 EPA06336.1 - 0.55 10.0 5.9 0.21 11.3 0.2 2.7 2 2 0 2 2 2 0 Prefoldin subunit Baculo_PEP_C PF04513.7 EPA06336.1 - 0.64 9.8 7.8 0.17 11.7 2.3 2.0 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.6 EPA06336.1 - 3.5 7.5 6.8 3 7.7 0.6 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Cupredoxin_1 PF13473.1 EPA06337.1 - 3e-06 27.0 0.0 8.1e-06 25.6 0.0 1.8 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.15 EPA06337.1 - 6.5e-06 26.3 0.0 1.6e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family DUF1679 PF07914.6 EPA06338.1 - 0.016 13.8 1.1 0.019 13.5 0.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) bZIP_2 PF07716.10 EPA06338.1 - 0.077 12.8 5.0 0.17 11.7 3.4 1.7 1 1 0 1 1 1 0 Basic region leucine zipper GLE1 PF07817.8 EPA06338.1 - 0.16 10.8 3.1 0.18 10.7 2.2 1.0 1 0 0 1 1 1 0 GLE1-like protein Arch_flagellin PF01917.11 EPA06340.1 - 3.9e-21 75.5 9.9 4.6e-21 75.3 6.9 1.1 1 0 0 1 1 1 1 Archaebacterial flagellin DUF1628 PF07790.6 EPA06340.1 - 1.9 9.3 6.4 6.8 7.5 4.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1628) EntA_Immun PF08951.5 EPA06341.1 - 0.06 13.5 1.4 0.07 13.2 1.0 1.1 1 0 0 1 1 1 0 Enterocin A Immunity UvrD_C PF13361.1 EPA06341.1 - 0.062 12.7 0.2 0.062 12.7 0.1 1.0 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Death PF00531.17 EPA06341.1 - 0.064 13.0 0.1 0.069 12.9 0.0 1.1 1 0 0 1 1 1 0 Death domain TrmB PF01978.14 EPA06343.1 - 8.9e-15 54.1 0.0 2.4e-14 52.7 0.0 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.3 EPA06343.1 - 2e-06 26.9 0.2 2.7e-06 26.5 0.2 1.2 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB HTH_5 PF01022.15 EPA06343.1 - 0.0054 16.3 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_11 PF08279.7 EPA06343.1 - 0.014 14.9 0.0 0.052 13.2 0.0 2.0 1 0 0 1 1 1 0 HTH domain HTH_24 PF13412.1 EPA06343.1 - 0.024 14.0 0.0 0.05 12.9 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_20 PF12840.2 EPA06343.1 - 0.039 13.7 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain PNK3P PF08645.6 EPA06343.1 - 0.059 12.8 1.3 0.082 12.3 0.1 1.7 2 1 0 2 2 2 0 Polynucleotide kinase 3 phosphatase Pup PF05639.6 EPA06343.1 - 0.086 13.3 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Pup-like protein DUF1059 PF06348.6 EPA06344.1 - 7e-06 25.7 0.4 8e-06 25.5 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) HATPase_c PF02518.21 EPA06345.1 - 6.1e-21 74.2 0.2 1.3e-20 73.1 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.1 EPA06345.1 - 8.1e-21 74.3 0.2 2.1e-20 73.0 0.0 1.8 2 0 0 2 2 2 1 PAS domain HisKA PF00512.20 EPA06345.1 - 2.7e-12 46.5 0.3 5.5e-12 45.5 0.2 1.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS PF00989.19 EPA06345.1 - 4.8e-10 39.2 0.0 1.8e-09 37.3 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.6 EPA06345.1 - 7.6e-10 38.7 0.2 1.5e-09 37.7 0.1 1.6 1 0 0 1 1 1 1 PAS fold HATPase_c_5 PF14501.1 EPA06345.1 - 1.5e-08 34.2 0.5 4e-08 32.8 0.4 1.7 1 0 0 1 1 1 1 GHKL domain PAS_4 PF08448.5 EPA06345.1 - 1.8e-08 34.3 0.0 2.8e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.1 EPA06345.1 - 3.7e-05 23.3 0.4 8.8e-05 22.1 0.3 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MAPKK1_Int PF08923.5 EPA06345.1 - 0.0066 16.0 0.3 0.026 14.1 0.1 2.0 2 0 0 2 2 2 1 Mitogen-activated protein kinase kinase 1 interacting PAS_8 PF13188.1 EPA06345.1 - 0.018 14.8 0.0 0.052 13.4 0.0 1.7 1 0 0 1 1 1 0 PAS domain DUF848 PF05852.6 EPA06345.1 - 0.031 14.1 0.2 0.06 13.1 0.2 1.4 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) HATPase_c_2 PF13581.1 EPA06345.1 - 0.033 13.9 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain BLOC1_2 PF10046.4 EPA06345.1 - 0.25 11.4 2.2 0.25 11.5 0.3 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PAN_3 PF08277.7 EPA06347.1 - 0.081 12.5 0.0 0.14 11.7 0.0 1.4 1 1 0 1 1 1 0 PAN-like domain TPR_11 PF13414.1 EPA06348.1 - 1.4e-52 175.1 22.3 1e-10 41.0 2.2 8.2 6 1 3 9 9 9 9 TPR repeat TPR_2 PF07719.12 EPA06348.1 - 6.7e-48 156.7 10.4 5.4e-05 22.7 0.2 14.1 15 0 0 15 15 14 8 Tetratricopeptide repeat TPR_1 PF00515.23 EPA06348.1 - 1.3e-47 157.5 28.9 5e-08 32.2 0.9 12.8 13 0 0 13 13 12 9 Tetratricopeptide repeat TPR_16 PF13432.1 EPA06348.1 - 5.1e-42 141.6 0.0 5.3e-05 23.7 0.0 8.0 5 1 4 9 9 9 9 Tetratricopeptide repeat TPR_19 PF14559.1 EPA06348.1 - 4.6e-40 135.8 1.5 9e-06 25.9 0.0 8.7 5 2 5 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.1 EPA06348.1 - 8.7e-35 115.8 41.1 1.4e-05 24.5 0.0 15.0 13 2 2 15 15 15 7 Tetratricopeptide repeat TPR_14 PF13428.1 EPA06348.1 - 8e-31 103.7 0.0 0.064 13.9 0.0 12.4 4 3 7 12 12 12 7 Tetratricopeptide repeat TPR_6 PF13174.1 EPA06348.1 - 6.9e-28 95.1 0.2 0.24 11.9 0.0 13.1 13 1 0 13 13 13 3 Tetratricopeptide repeat TPR_17 PF13431.1 EPA06348.1 - 2.1e-26 89.8 23.3 0.00042 20.2 0.3 11.3 13 0 0 13 13 11 6 Tetratricopeptide repeat Apc3 PF12895.2 EPA06348.1 - 6.4e-26 90.3 26.3 3.1e-06 27.2 0.0 7.5 2 2 6 9 9 9 8 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 EPA06348.1 - 1.6e-24 83.7 3.9 0.015 15.0 0.0 10.9 11 1 0 11 11 11 5 Tetratricopeptide repeat TPR_12 PF13424.1 EPA06348.1 - 1.9e-21 75.8 20.9 0.00022 21.0 0.0 9.4 2 2 9 12 12 12 7 Tetratricopeptide repeat TPR_9 PF13371.1 EPA06348.1 - 3e-17 62.2 0.0 0.014 15.2 0.0 7.0 3 2 6 9 9 9 4 Tetratricopeptide repeat TPR_20 PF14561.1 EPA06348.1 - 6.5e-10 38.9 2.9 0.14 12.3 0.0 7.0 4 2 4 9 9 9 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EPA06348.1 - 4e-08 33.0 12.9 0.56 10.1 0.0 8.2 7 1 2 9 9 9 3 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.1 EPA06348.1 - 5.9e-08 32.3 0.5 8.4 6.4 0.0 7.7 11 0 0 11 11 9 0 Tetratricopeptide repeat Rapsyn_N PF10579.4 EPA06348.1 - 2.2e-06 27.3 0.0 5.1 6.9 0.0 5.8 5 0 0 5 5 5 1 Rapsyn N-terminal myristoylation and linker region NARP1 PF12569.3 EPA06348.1 - 6.7e-06 25.1 19.7 0.031 13.0 0.7 6.5 1 1 6 7 7 7 3 NMDA receptor-regulated protein 1 Coatomer_E PF04733.9 EPA06348.1 - 9.3e-06 25.0 13.1 0.15 11.2 1.2 4.5 3 1 1 4 4 4 3 Coatomer epsilon subunit DDT PF02791.12 EPA06348.1 - 0.00019 21.1 0.6 16 5.3 0.0 5.5 7 0 0 7 7 5 0 DDT domain TOM20_plant PF06552.7 EPA06348.1 - 0.0015 18.1 1.4 4.8 6.7 0.0 4.2 3 1 0 3 3 3 1 Plant specific mitochondrial import receptor subunit TOM20 ChAPs PF09295.5 EPA06348.1 - 0.0025 16.6 9.9 0.13 10.9 0.5 3.7 1 1 1 4 4 4 2 ChAPs (Chs5p-Arf1p-binding proteins) SPOB_a PF14689.1 EPA06348.1 - 0.033 13.7 3.2 18 5.0 0.0 4.9 7 0 0 7 7 7 0 Sensor_kinase_SpoOB-type, alpha-helical domain MIT PF04212.13 EPA06348.1 - 3.9 7.4 15.8 13 5.7 0.1 6.5 7 1 1 8 8 8 0 MIT (microtubule interacting and transport) domain Arch_flagellin PF01917.11 EPA06349.1 - 9.5e-20 71.0 10.8 1.3e-19 70.6 7.5 1.2 1 0 0 1 1 1 1 Archaebacterial flagellin DUF1628 PF07790.6 EPA06349.1 - 2 9.2 9.8 4.4 8.1 4.8 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1628) Blt1 PF12754.2 EPA06350.1 - 0.041 13.4 0.8 0.059 12.9 0.6 1.1 1 0 0 1 1 1 0 Cell-cycle control medial ring component Cu-oxidase_3 PF07732.10 EPA06352.1 - 5.1e-10 39.1 2.5 7.5e-09 35.3 0.4 2.5 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 EPA06352.1 - 0.0045 16.5 2.5 0.25 10.8 0.1 2.6 2 0 0 2 2 2 2 Multicopper oxidase HSDR_N_2 PF13588.1 EPA06353.1 - 0.088 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) SLEI_Leptospira PF07620.6 EPA06353.1 - 4.4 7.3 6.8 0.23 11.3 0.5 2.0 2 0 0 2 2 2 0 SLEI Tubulin PF00091.20 EPA06355.1 - 6.4e-15 55.5 1.1 9.8e-14 51.6 0.2 2.4 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Lyase_1 PF00206.15 EPA06357.1 - 5.6e-89 298.4 1.6 6.8e-89 298.1 1.1 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.4 EPA06357.1 - 1.8e-12 47.0 0.0 5.1e-12 45.6 0.0 1.8 1 0 0 1 1 1 1 Fumarase C C-terminus Ribosomal_L15e PF00827.12 EPA06358.1 - 3.6e-44 150.5 3.9 4.4e-44 150.2 2.7 1.0 1 0 0 1 1 1 1 Ribosomal L15 Radical_SAM PF04055.16 EPA06359.1 - 8.5e-20 71.5 0.1 1.2e-19 71.0 0.1 1.2 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.15 EPA06359.1 - 3.4e-15 55.6 1.3 4.8e-15 55.1 0.1 1.9 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 TRAM PF01938.15 EPA06359.1 - 0.01 15.6 0.4 0.035 13.9 0.1 2.1 2 0 0 2 2 2 0 TRAM domain 2-Hacid_dh_C PF02826.14 EPA06360.1 - 1.7e-63 212.9 0.5 3e-63 212.1 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EPA06360.1 - 1e-28 99.4 0.2 1.1e-28 99.2 0.2 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EPA06360.1 - 0.0008 19.2 0.6 0.0028 17.5 0.0 2.0 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase DUF3436 PF11918.3 EPA06360.1 - 0.019 15.1 0.0 0.084 13.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3436) ThiC PF01964.13 EPA06360.1 - 0.051 12.0 1.9 0.11 11.0 0.8 1.7 2 0 0 2 2 2 0 ThiC family A2M_N PF01835.14 EPA06364.1 - 9.5e-07 29.0 0.1 0.00036 20.7 0.0 2.8 2 0 0 2 2 2 1 MG2 domain YtkA PF13115.1 EPA06364.1 - 0.0027 18.0 0.0 0.71 10.2 0.1 2.7 2 0 0 2 2 2 1 YtkA-like DUF812 PF05667.6 EPA06364.1 - 0.0067 15.0 8.3 0.0098 14.4 5.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Filamin PF00630.14 EPA06364.1 - 0.0072 16.8 1.4 0.15 12.6 0.0 2.5 1 1 0 2 2 2 1 Filamin/ABP280 repeat Atg14 PF10186.4 EPA06364.1 - 0.014 14.4 4.9 0.021 13.7 3.4 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3450 PF11932.3 EPA06364.1 - 0.019 14.2 2.8 0.032 13.4 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Big_1 PF02369.11 EPA06364.1 - 0.037 13.9 3.3 0.43 10.5 0.2 2.7 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) DUF4140 PF13600.1 EPA06364.1 - 0.053 13.9 2.3 0.19 12.1 1.6 2.0 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF3437 PF11919.3 EPA06364.1 - 0.095 12.4 0.2 0.24 11.1 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) HAUS6_N PF14661.1 EPA06364.1 - 0.3 10.3 6.8 0.51 9.6 4.7 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Striatin PF08232.7 EPA06364.1 - 0.31 11.3 11.1 0.55 10.5 7.7 1.3 1 0 0 1 1 1 0 Striatin family IncA PF04156.9 EPA06364.1 - 0.62 9.6 7.7 1.4 8.5 5.3 1.5 1 0 0 1 1 1 0 IncA protein NRDD PF13597.1 EPA06365.1 - 1.8e-20 72.5 0.0 7.2e-18 63.9 0.0 2.3 2 0 0 2 2 2 2 Anaerobic ribonucleoside-triphosphate reductase HTH_20 PF12840.2 EPA06365.1 - 6.8e-10 38.6 0.0 2.2e-09 36.9 0.0 2.0 1 0 0 1 1 1 1 Helix-turn-helix domain ATP-cone PF03477.11 EPA06365.1 - 4e-08 33.5 1.9 6.7e-07 29.6 0.0 3.9 4 1 1 5 5 5 1 ATP cone domain HTH_24 PF13412.1 EPA06365.1 - 0.042 13.2 0.2 1.4 8.3 0.0 2.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF2252 PF10009.4 EPA06365.1 - 0.18 10.6 0.0 0.38 9.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) Histidinol_dh PF00815.15 EPA06366.1 - 0.0054 15.4 0.0 0.0054 15.4 0.0 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase HisG PF01634.13 EPA06367.1 - 1.1e-37 129.1 0.0 1.4e-37 128.7 0.0 1.1 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.6 EPA06367.1 - 7.8e-14 51.3 0.0 1.8e-13 50.2 0.0 1.6 1 0 0 1 1 1 1 HisG, C-terminal domain Histidinol_dh PF00815.15 EPA06368.1 - 3.5e-121 404.7 0.2 4.4e-121 404.3 0.1 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase Tubulin_C PF03953.12 EPA06368.1 - 0.026 14.5 0.0 0.075 13.0 0.0 1.7 1 0 0 1 1 1 0 Tubulin C-terminal domain DUF643 PF04867.7 EPA06368.1 - 3.6 8.0 9.7 0.11 12.9 0.5 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF643) Aminotran_1_2 PF00155.16 EPA06371.1 - 1.8e-38 132.4 0.0 2e-38 132.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.8 EPA06371.1 - 1e-05 24.3 0.0 1.3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Allinase Aminotran_5 PF00266.14 EPA06371.1 - 0.027 13.2 0.0 0.092 11.4 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class-V A2M_N PF01835.14 EPA06372.1 - 4.4e-12 46.1 0.7 5.1e-06 26.6 0.0 4.2 4 2 0 4 4 4 3 MG2 domain LTD PF00932.14 EPA06372.1 - 4.5e-11 42.8 0.8 4.5e-11 42.8 0.5 2.8 3 1 0 3 3 3 1 Lamin Tail Domain HMG-CoA_red PF00368.13 EPA06374.1 - 1.9e-49 168.3 3.0 2.3e-49 168.0 2.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase GatB_Yqey PF02637.13 EPA06374.1 - 0.058 13.1 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 GatB domain DUF4097 PF13349.1 EPA06375.1 - 0.02 14.4 0.0 0.022 14.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4097) AsnC_trans_reg PF01037.16 EPA06376.1 - 1.7e-10 40.4 0.1 1.8e-10 40.3 0.1 1.0 1 0 0 1 1 1 1 AsnC family Polysacc_synt_C PF14667.1 EPA06377.1 - 0.24 11.1 2.7 0.34 10.6 1.8 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain DUF3185 PF11381.3 EPA06377.1 - 2.3 8.0 8.4 2.3 8.0 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) DUF3040 PF11239.3 EPA06377.1 - 2.5 8.2 5.5 15 5.7 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) Molybdop_Fe4S4 PF04879.11 EPA06378.1 - 0.0023 17.7 7.0 0.23 11.3 0.4 2.3 2 0 0 2 2 2 2 Molybdopterin oxidoreductase Fe4S4 domain DNA_RNApol_7kD PF03604.8 EPA06378.1 - 0.0078 15.6 15.4 0.39 10.2 2.7 2.8 2 0 0 2 2 2 2 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_6 PF14599.1 EPA06378.1 - 0.03 14.1 9.7 0.53 10.1 1.0 2.8 2 2 0 2 2 2 0 Zinc-ribbon DZR PF12773.2 EPA06378.1 - 0.052 13.3 13.9 0.57 10.0 2.0 2.4 2 0 0 2 2 2 0 Double zinc ribbon DUF4001 PF13165.1 EPA06378.1 - 0.22 11.2 10.0 1.7 8.3 0.2 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF4001) Stig1 PF04885.8 EPA06378.1 - 0.23 11.6 4.4 9.7 6.3 0.2 2.4 2 0 0 2 2 2 0 Stigma-specific protein, Stig1 CpXC PF14353.1 EPA06378.1 - 0.32 10.9 4.1 7.8 6.4 0.3 2.3 2 0 0 2 2 2 0 CpXC protein NUC205 PF08168.6 EPA06378.1 - 0.34 10.3 1.5 19 4.7 0.1 2.2 2 0 0 2 2 2 0 NUC205 domain LIM PF00412.17 EPA06378.1 - 0.86 9.7 13.0 3.5 7.7 1.8 2.3 2 0 0 2 2 2 0 LIM domain C1_1 PF00130.17 EPA06378.1 - 0.94 9.2 11.1 4.3 7.1 1.2 2.4 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.5 EPA06378.1 - 5.6 6.9 17.3 6.9 6.7 3.1 2.3 2 0 0 2 2 2 0 Zinc ribbon domain HypA PF01155.14 EPA06378.1 - 7.6 6.2 10.3 5.4 6.7 0.7 2.2 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family Elf1 PF05129.8 EPA06378.1 - 8.3 6.1 10.8 5.1 6.8 0.3 2.9 2 2 1 3 3 3 0 Transcription elongation factor Elf1 like DUF2177 PF09945.4 EPA06380.1 - 0.0059 16.6 0.8 0.0069 16.3 0.5 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2177) TRAM1 PF08390.6 EPA06380.1 - 0.12 11.9 0.8 0.2 11.2 0.6 1.3 1 0 0 1 1 1 0 TRAM1-like protein ADH_zinc_N_2 PF13602.1 EPA06381.1 - 1.7e-05 25.7 0.0 1.7e-05 25.6 0.0 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 EPA06381.1 - 0.00026 20.5 0.1 0.00039 19.9 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CoA_binding PF02629.14 EPA06381.1 - 0.0013 19.1 0.7 0.032 14.7 0.1 2.1 2 0 0 2 2 2 1 CoA binding domain CLU_N PF15044.1 EPA06381.1 - 0.065 13.4 0.0 0.084 13.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial function, CLU-N-term TruD PF01142.13 EPA06384.1 - 3.6e-11 42.3 0.0 3.9e-11 42.2 0.0 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) DNA_pol3_a_NI PF14480.1 EPA06384.1 - 0.0082 15.7 0.1 1.8 8.2 0.0 2.1 1 1 1 2 2 2 2 DNA polymerase III polC-type N-terminus I AAA_33 PF13671.1 EPA06386.1 - 1.6e-17 63.7 0.0 1.9e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EPA06386.1 - 8e-05 23.4 0.0 0.00011 22.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF3791 PF12668.2 EPA06386.1 - 0.00065 19.2 0.9 0.0018 17.8 0.3 2.0 3 0 0 3 3 3 1 Protein of unknown function (DUF3791) KTI12 PF08433.5 EPA06386.1 - 0.0017 17.6 0.0 0.0019 17.4 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.7 EPA06386.1 - 0.0018 17.4 0.1 0.0044 16.1 0.1 1.6 1 1 0 1 1 1 1 Zeta toxin AAA_18 PF13238.1 EPA06386.1 - 0.0023 18.2 2.3 0.0049 17.1 1.6 1.6 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.17 EPA06386.1 - 0.072 12.5 0.5 0.66 9.3 0.3 2.1 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain HTH_10 PF04967.7 EPA06386.1 - 0.13 11.8 0.1 1.6 8.3 0.0 2.3 2 0 0 2 2 2 0 HTH DNA binding domain AAA_22 PF13401.1 EPA06386.1 - 0.15 12.2 2.2 2 8.5 1.5 2.2 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.12 EPA06386.1 - 0.16 11.4 0.7 0.46 9.9 0.1 1.9 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Tmemb_55A PF09788.4 EPA06387.1 - 0.001 18.2 0.7 0.0015 17.7 0.5 1.2 1 0 0 1 1 1 1 Transmembrane protein 55A Lar_restr_allev PF14354.1 EPA06387.1 - 0.009 16.2 1.8 0.024 14.9 1.3 1.7 1 0 0 1 1 1 1 Restriction alleviation protein Lar zinc_ribbon_5 PF13719.1 EPA06387.1 - 0.0099 15.4 3.9 0.023 14.2 2.7 1.6 1 0 0 1 1 1 1 zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 EPA06387.1 - 0.019 14.5 3.3 0.045 13.4 2.3 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zinc_ribbon_4 PF13717.1 EPA06387.1 - 0.046 13.4 4.2 0.12 12.1 2.9 1.7 1 0 0 1 1 1 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.7 EPA06387.1 - 0.12 11.6 5.7 0.3 10.4 3.9 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding Cys_rich_CPCC PF14206.1 EPA06387.1 - 0.21 11.1 2.2 0.5 9.9 1.5 1.6 1 0 0 1 1 1 0 Cysteine-rich CPCC Zn_ribbon_recom PF13408.1 EPA06387.1 - 0.89 9.8 4.3 14 6.0 1.2 2.8 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain Prim_Zn_Ribbon PF08273.7 EPA06387.1 - 1.3 9.2 5.9 3.6 7.7 4.1 1.7 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase Elf1 PF05129.8 EPA06387.1 - 2.3 7.9 6.3 1.1 8.9 2.7 1.7 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like DNA_RNApol_7kD PF03604.8 EPA06387.1 - 2.8 7.4 11.3 1 8.9 4.9 2.4 2 1 1 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zf-TFIIB PF13453.1 EPA06387.1 - 6 6.1 11.5 0.35 10.1 4.0 1.9 2 0 0 2 2 2 0 Transcription factor zinc-finger DUF4182 PF13790.1 EPA06388.1 - 0.15 11.8 1.3 0.35 10.6 0.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4182) zf-CHY PF05495.7 EPA06388.1 - 0.49 10.5 5.5 0.58 10.3 3.8 1.3 1 1 0 1 1 1 0 CHY zinc finger DUF2196 PF09962.4 EPA06389.1 - 1.2e-28 98.6 1.3 1.3e-28 98.5 0.9 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2196) ADH_N PF08240.7 EPA06390.1 - 4.7e-24 84.2 0.1 8.7e-24 83.3 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EPA06390.1 - 1.1e-06 28.2 0.2 1.7e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 EPA06390.1 - 0.00025 20.2 0.3 0.00037 19.7 0.2 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 EPA06390.1 - 0.061 12.8 0.3 0.097 12.2 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_10 PF13460.1 EPA06390.1 - 0.14 12.1 0.2 0.26 11.2 0.2 1.4 1 0 0 1 1 1 0 NADH(P)-binding Met_synt_B12 PF02965.12 EPA06391.1 - 8.2e-06 25.1 0.1 8.5e-06 25.1 0.1 1.0 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain MTHFR PF02219.12 EPA06392.1 - 1.6e-07 30.7 0.1 0.0036 16.4 0.0 2.1 2 0 0 2 2 2 2 Methylenetetrahydrofolate reductase HpaB PF03241.8 EPA06392.1 - 0.1 11.4 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase C terminal Glyco_trans_1_3 PF13528.1 EPA06393.1 - 4.4e-10 39.2 0.0 8.4e-09 35.0 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 1 Alg14 PF08660.6 EPA06393.1 - 0.0032 17.4 0.0 0.0075 16.2 0.0 1.6 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like tRNA_deacylase PF04414.7 EPA06393.1 - 0.066 12.3 1.3 0.96 8.5 0.0 2.5 2 1 1 3 3 3 0 D-aminoacyl-tRNA deacylase WhiA_N PF10298.4 EPA06394.1 - 0.0041 16.9 0.3 0.4 10.5 0.0 3.1 3 0 0 3 3 3 2 WhiA N-terminal LAGLIDADG-like domain TF_Zn_Ribbon PF08271.7 EPA06395.1 - 0.032 13.5 0.6 0.5 9.7 0.0 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding Rpr2 PF04032.11 EPA06395.1 - 0.033 14.0 0.3 0.033 14.0 0.2 1.5 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Ribosomal_L32p PF01783.18 EPA06395.1 - 0.095 12.8 0.1 0.49 10.6 0.0 2.1 2 0 0 2 2 2 0 Ribosomal L32p protein family Zn_Tnp_IS1595 PF12760.2 EPA06395.1 - 0.1 12.3 0.4 15 5.5 0.1 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 EPA06395.1 - 0.11 12.1 0.5 3.3 7.4 0.0 2.2 2 0 0 2 2 2 0 Putative transposase DNA-binding domain PUA_2 PF14306.1 EPA06396.1 - 6e-09 35.5 0.0 1.2e-08 34.5 0.0 1.5 1 1 0 1 1 1 1 PUA-like domain PAPS_reduct PF01507.14 EPA06397.1 - 1.3e-43 148.8 0.0 1.6e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Endotoxin_N PF03945.9 EPA06398.1 - 0.081 12.3 0.2 0.082 12.2 0.1 1.0 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain PUA_2 PF14306.1 EPA06399.1 - 4.8e-27 94.3 0.1 5.4e-27 94.1 0.1 1.0 1 0 0 1 1 1 1 PUA-like domain GATase PF00117.23 EPA06400.1 - 1.5e-20 73.4 0.0 1.8e-20 73.2 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EPA06400.1 - 5.9e-10 38.9 0.0 5.9e-09 35.6 0.0 2.0 1 1 0 1 1 1 1 Peptidase C26 SNO PF01174.14 EPA06400.1 - 0.0053 16.4 0.0 0.33 10.5 0.0 2.2 2 0 0 2 2 2 2 SNO glutamine amidotransferase family TPR_11 PF13414.1 EPA06401.1 - 9.8e-21 73.1 10.6 5.4e-13 48.3 2.8 2.5 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 EPA06401.1 - 6.5e-15 54.0 17.0 1.9e-08 33.5 1.0 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.12 EPA06401.1 - 1.3e-12 46.5 11.3 1.8e-06 27.3 0.3 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 EPA06401.1 - 5.5e-12 44.8 13.1 0.00017 21.5 0.9 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 EPA06401.1 - 6.9e-09 35.5 6.8 1e-06 28.5 0.9 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 EPA06401.1 - 8.2e-08 32.4 0.9 0.0095 16.2 0.1 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 EPA06401.1 - 2.1e-07 31.4 0.0 0.0043 17.6 0.0 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 EPA06401.1 - 9.8e-07 28.8 0.0 0.046 14.3 0.0 3.3 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 EPA06401.1 - 4.2e-05 23.0 25.2 0.0011 18.5 1.3 5.6 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.1 EPA06401.1 - 7e-05 23.0 3.9 0.63 10.6 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 EPA06401.1 - 0.00027 20.7 0.0 0.0019 18.0 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Peptidase_C39_2 PF13529.1 EPA06401.1 - 0.00093 19.5 0.0 0.0024 18.2 0.0 1.7 1 0 0 1 1 1 1 Peptidase_C39 like family Peptidase_C39 PF03412.10 EPA06401.1 - 0.023 14.4 0.2 0.081 12.7 0.0 2.0 3 1 0 3 3 3 0 Peptidase C39 family TPR_7 PF13176.1 EPA06401.1 - 0.18 11.6 1.3 15 5.6 0.0 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat UPF0182 PF03699.8 EPA06402.1 - 1.8e-31 108.9 7.5 3.7e-30 104.5 5.2 2.1 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0182) GSDH PF07995.6 EPA06403.1 - 1.2e-08 34.4 0.0 1.2e-08 34.4 0.0 1.0 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase HMG-CoA_red PF00368.13 EPA06404.1 - 1.5e-20 73.2 0.0 1.6e-20 73.0 0.0 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase GSDH PF07995.6 EPA06405.1 - 3.2e-54 184.2 0.0 3.8e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase NHL PF01436.16 EPA06405.1 - 0.012 15.4 0.0 1.2 9.2 0.0 3.0 3 0 0 3 3 3 0 NHL repeat tRNA_anti_2 PF13742.1 EPA06406.1 - 0.035 13.9 0.0 0.042 13.6 0.0 1.2 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain ATP_bind_4 PF01902.12 EPA06407.1 - 2.2e-58 197.2 0.2 2.5e-58 197.0 0.1 1.0 1 0 0 1 1 1 1 ATP-binding region Asn_synthase PF00733.16 EPA06407.1 - 1.4e-05 24.7 0.1 3.1e-05 23.6 0.0 1.5 2 0 0 2 2 2 1 Asparagine synthase QueC PF06508.8 EPA06407.1 - 0.012 14.9 0.0 0.034 13.4 0.0 1.9 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 EPA06407.1 - 0.066 11.7 0.0 0.18 10.3 0.0 1.7 2 0 0 2 2 2 0 tRNA methyl transferase SRP54 PF00448.17 EPA06409.1 - 3.5e-31 108.1 0.3 9.8e-31 106.7 0.0 1.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP54_N PF02881.14 EPA06409.1 - 8.4e-16 57.8 1.8 1.3e-15 57.2 1.2 1.3 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain CbiA PF01656.18 EPA06409.1 - 2.7e-07 30.2 0.4 6.4e-07 28.9 0.3 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.9 EPA06409.1 - 4e-05 23.3 0.7 0.0001 21.9 0.4 1.7 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B KTI12 PF08433.5 EPA06409.1 - 0.00015 21.0 0.5 0.0003 20.0 0.0 1.7 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_17 PF13207.1 EPA06409.1 - 0.00016 22.4 0.3 0.00054 20.7 0.0 2.0 2 1 0 2 2 2 1 AAA domain 6PF2K PF01591.13 EPA06409.1 - 0.00018 20.6 0.2 0.00032 19.8 0.0 1.4 2 0 0 2 2 2 1 6-phosphofructo-2-kinase ArgK PF03308.11 EPA06409.1 - 0.00026 19.8 0.1 0.001 17.9 0.0 1.9 3 0 0 3 3 3 1 ArgK protein AAA_18 PF13238.1 EPA06409.1 - 0.00034 20.9 1.8 0.0038 17.5 0.1 2.4 2 1 0 2 2 2 1 AAA domain APS_kinase PF01583.15 EPA06409.1 - 0.00036 20.2 0.8 0.00082 19.0 0.0 1.9 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_33 PF13671.1 EPA06409.1 - 0.0015 18.4 0.1 0.0037 17.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain Arf PF00025.16 EPA06409.1 - 0.0015 17.7 0.1 0.0033 16.6 0.1 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.1 EPA06409.1 - 0.0019 18.3 0.6 0.0087 16.2 0.0 2.1 2 1 0 2 2 2 1 AAA domain LpxK PF02606.9 EPA06409.1 - 0.0025 16.8 0.0 0.004 16.1 0.0 1.4 1 0 0 1 1 1 1 Tetraacyldisaccharide-1-P 4'-kinase Thymidylate_kin PF02223.12 EPA06409.1 - 0.0031 16.9 0.9 0.0064 15.8 0.3 1.7 2 0 0 2 2 2 1 Thymidylate kinase cobW PF02492.14 EPA06409.1 - 0.0056 16.1 0.3 0.012 15.0 0.2 1.7 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.12 EPA06409.1 - 0.0056 16.2 0.1 0.011 15.2 0.1 1.5 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Zeta_toxin PF06414.7 EPA06409.1 - 0.0061 15.6 0.0 0.01 14.9 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.1 EPA06409.1 - 0.0062 16.5 0.4 0.044 13.7 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain AAA_10 PF12846.2 EPA06409.1 - 0.0064 15.9 1.4 0.088 12.2 0.2 2.1 1 1 1 2 2 2 1 AAA-like domain MipZ PF09140.6 EPA06409.1 - 0.0079 15.3 0.5 0.23 10.5 0.4 2.2 1 1 0 1 1 1 1 ATPase MipZ AAA_25 PF13481.1 EPA06409.1 - 0.0081 15.5 0.9 0.16 11.3 0.7 2.2 1 1 0 1 1 1 1 AAA domain Mur_ligase_M PF08245.7 EPA06409.1 - 0.01 15.8 0.1 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 Mur ligase middle domain AAA_30 PF13604.1 EPA06409.1 - 0.014 15.0 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_31 PF13614.1 EPA06409.1 - 0.018 14.9 0.0 0.044 13.7 0.0 1.7 2 0 0 2 2 1 0 AAA domain NTPase_1 PF03266.10 EPA06409.1 - 0.025 14.3 0.6 0.025 14.3 0.4 1.9 2 1 0 2 2 2 0 NTPase ABC_tran PF00005.22 EPA06409.1 - 0.025 14.8 0.2 0.048 13.9 0.0 1.6 2 0 0 2 2 1 0 ABC transporter SRPRB PF09439.5 EPA06409.1 - 0.03 13.5 0.1 0.071 12.3 0.1 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_5 PF07728.9 EPA06409.1 - 0.032 13.9 0.1 0.065 12.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SpoVIF PF14069.1 EPA06409.1 - 0.039 13.6 0.8 0.039 13.6 0.5 1.8 2 1 0 2 2 1 0 Stage VI sporulation protein F AAA_28 PF13521.1 EPA06409.1 - 0.047 13.6 0.2 0.075 12.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.15 EPA06409.1 - 0.051 12.2 0.7 0.065 11.9 0.3 1.4 1 1 0 1 1 1 0 G-protein alpha subunit AAA_26 PF13500.1 EPA06409.1 - 0.09 12.3 0.9 0.26 10.8 0.4 1.9 1 1 0 1 1 1 0 AAA domain Glyco_transf_4 PF13439.1 EPA06409.1 - 0.11 12.2 0.0 0.51 10.0 0.0 1.9 2 0 0 2 2 2 0 Glycosyltransferase Family 4 PduV-EutP PF10662.4 EPA06409.1 - 0.11 11.9 1.2 0.21 11.0 0.3 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.12 EPA06409.1 - 0.12 11.8 0.1 0.28 10.5 0.0 1.6 2 0 0 2 2 1 0 IstB-like ATP binding protein AAA_24 PF13479.1 EPA06409.1 - 0.14 11.7 0.7 0.3 10.6 0.5 1.7 1 1 0 1 1 1 0 AAA domain ArsA_ATPase PF02374.10 EPA06409.1 - 0.24 10.4 1.9 0.62 9.0 0.3 2.2 3 0 0 3 3 3 0 Anion-transporting ATPase DUF4398 PF14346.1 EPA06410.1 - 0.00015 21.7 6.1 0.00032 20.6 4.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4398) BCDHK_Adom3 PF10436.4 EPA06410.1 - 0.1 12.1 0.8 0.17 11.3 0.5 1.5 1 1 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase TPR_1 PF00515.23 EPA06410.1 - 0.13 11.8 0.5 4 7.2 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.13 EPA06410.1 - 0.52 10.2 3.8 2.1 8.3 0.3 2.9 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain GvpG PF05120.7 EPA06410.1 - 0.66 9.8 4.6 6.9 6.5 0.7 3.0 2 1 1 3 3 3 0 Gas vesicle protein G TPR_2 PF07719.12 EPA06410.1 - 0.7 9.9 3.2 28 4.9 0.3 3.8 2 1 2 4 4 4 0 Tetratricopeptide repeat Prp18 PF02840.10 EPA06410.1 - 0.79 9.5 6.4 0.12 12.1 1.4 1.8 1 1 1 2 2 2 0 Prp18 domain FUSC-like PF12805.2 EPA06410.1 - 1.5 7.6 4.0 0.8 8.5 1.3 1.5 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS CorA PF01544.13 EPA06410.1 - 1.7 7.6 7.7 1.6 7.7 2.8 2.1 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein AHH PF14412.1 EPA06410.1 - 3.6 7.6 9.1 3.6 7.6 0.6 2.9 1 1 1 2 2 2 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH KIP1 PF07765.7 EPA06410.1 - 4.9 7.0 6.6 7.3 6.5 1.1 2.9 1 1 1 2 2 2 0 KIP1-like protein Mo25 PF08569.6 EPA06410.1 - 6 5.7 10.2 0.065 12.2 1.2 1.8 2 0 0 2 2 2 0 Mo25-like SHOCT PF09851.4 EPA06411.1 - 5.5e-09 35.1 0.4 6e-09 35.0 0.3 1.1 1 0 0 1 1 1 1 Short C-terminal domain HTH_CodY PF08222.6 EPA06411.1 - 0.13 11.5 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 CodY helix-turn-helix domain Ribosomal_L37ae PF01780.14 EPA06412.1 - 0.021 14.6 0.1 0.021 14.6 0.1 1.1 1 0 0 1 1 1 0 Ribosomal L37ae protein family Tnp_zf-ribbon_2 PF13842.1 EPA06412.1 - 0.029 14.7 0.5 0.036 14.4 0.3 1.2 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon C1_2 PF03107.11 EPA06412.1 - 0.062 13.4 0.6 0.075 13.1 0.4 1.3 1 0 0 1 1 1 0 C1 domain zf-3CxxC PF13695.1 EPA06412.1 - 0.09 13.0 0.7 0.088 13.0 0.5 1.2 1 0 0 1 1 1 0 Zinc-binding domain zf-C2H2_4 PF13894.1 EPA06412.1 - 0.13 12.6 0.8 0.18 12.2 0.5 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger TFIIS_C PF01096.13 EPA06412.1 - 0.32 10.6 2.9 0.39 10.4 1.3 1.6 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-H2C2_2 PF13465.1 EPA06412.1 - 4.4 7.7 8.4 8.2 6.9 0.3 2.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-H2C2_5 PF13909.1 EPA06412.1 - 4.8 7.6 7.2 78 3.8 5.0 2.2 1 1 0 1 1 1 0 C2H2-type zinc-finger domain UPF0547 PF10571.4 EPA06413.1 - 0.0024 17.5 0.4 0.3 10.8 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised protein family UPF0547 Tnp_zf-ribbon_2 PF13842.1 EPA06413.1 - 0.0052 17.1 2.7 0.0077 16.6 1.8 1.3 1 1 0 1 1 1 1 DDE_Tnp_1-like zinc-ribbon Tmemb_55A PF09788.4 EPA06413.1 - 0.0084 15.2 0.7 0.0089 15.1 0.5 1.0 1 0 0 1 1 1 1 Transmembrane protein 55A DUF4379 PF14311.1 EPA06413.1 - 0.018 14.8 0.6 0.031 14.0 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4379) TF_Zn_Ribbon PF08271.7 EPA06413.1 - 0.019 14.2 0.8 0.29 10.4 0.0 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding RecR PF02132.10 EPA06413.1 - 0.021 14.2 3.2 0.72 9.3 0.3 2.1 1 1 1 2 2 2 0 RecR protein zf-ribbon_3 PF13248.1 EPA06413.1 - 0.028 13.6 2.2 0.76 9.0 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain DUF4206 PF13901.1 EPA06413.1 - 0.03 13.8 0.9 0.033 13.7 0.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) zf-C2HC5 PF06221.8 EPA06413.1 - 0.034 13.9 1.1 0.038 13.7 0.8 1.1 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type PhnA_Zn_Ribbon PF08274.7 EPA06413.1 - 0.046 13.4 1.4 4.9 7.0 0.1 2.2 2 0 0 2 2 2 0 PhnA Zinc-Ribbon DZR PF12773.2 EPA06413.1 - 0.047 13.5 1.8 0.072 12.9 1.3 1.4 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_2 PF13923.1 EPA06413.1 - 0.048 13.6 1.4 0.071 13.1 1.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Jiv90 PF14901.1 EPA06413.1 - 0.052 13.5 0.5 0.055 13.4 0.4 1.0 1 0 0 1 1 1 0 Cleavage inducing molecular chaperone Rtf2 PF04641.7 EPA06413.1 - 0.066 12.4 0.7 0.07 12.3 0.5 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger OrfB_Zn_ribbon PF07282.6 EPA06413.1 - 0.075 12.6 1.4 0.089 12.4 1.0 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn-ribbon_8 PF09723.5 EPA06413.1 - 0.082 12.8 2.1 0.2 11.6 1.5 1.7 1 1 0 1 1 1 0 Zinc ribbon domain COX5B PF01215.14 EPA06413.1 - 0.11 12.2 1.7 0.79 9.3 0.1 2.0 1 1 1 2 2 2 0 Cytochrome c oxidase subunit Vb HypA PF01155.14 EPA06413.1 - 0.11 12.2 0.7 0.1 12.2 0.5 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Spt4 PF06093.8 EPA06413.1 - 0.15 11.9 1.3 0.19 11.6 0.9 1.2 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger zf-RING_4 PF14570.1 EPA06413.1 - 0.18 11.4 1.7 0.32 10.6 1.2 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF164 PF02591.10 EPA06413.1 - 0.18 11.6 2.9 2.7 7.8 0.1 2.1 1 1 1 2 2 2 0 Putative zinc ribbon domain zinc_ribbon_5 PF13719.1 EPA06413.1 - 0.21 11.2 2.6 5.5 6.6 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-trcl PF13451.1 EPA06413.1 - 0.22 11.1 4.0 4.6 6.9 2.8 2.0 1 1 0 1 1 1 0 Probable zinc-binding domain DUF2769 PF10967.3 EPA06413.1 - 0.22 11.8 2.8 0.75 10.1 2.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2769) zinc_ribbon_4 PF13717.1 EPA06413.1 - 0.26 10.9 2.8 5.7 6.7 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Ribosomal_L32p PF01783.18 EPA06413.1 - 0.31 11.2 2.9 2.3 8.4 0.2 2.0 1 1 1 2 2 2 0 Ribosomal L32p protein family zf-MYND PF01753.13 EPA06413.1 - 0.31 10.9 1.9 0.57 10.0 1.3 1.5 1 1 0 1 1 1 0 MYND finger zf-HIT PF04438.11 EPA06413.1 - 0.54 9.9 3.0 10 5.8 0.1 2.1 2 0 0 2 2 2 0 HIT zinc finger Rubredoxin PF00301.15 EPA06413.1 - 0.7 9.8 4.1 12 5.9 2.8 2.1 1 1 0 1 1 1 0 Rubredoxin Zn_Tnp_IS1595 PF12760.2 EPA06413.1 - 0.96 9.3 3.8 4.1 7.2 2.6 1.9 1 1 0 1 1 1 0 Transposase zinc-ribbon domain zf-AN1 PF01428.11 EPA06413.1 - 0.98 9.3 4.0 6.5 6.7 0.4 2.2 1 1 1 2 2 2 0 AN1-like Zinc finger zf-C2H2_6 PF13912.1 EPA06413.1 - 2.3 8.2 4.9 3.1 7.8 0.1 2.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_4 PF13894.1 EPA06414.1 - 1e-06 28.6 9.2 0.00087 19.4 0.3 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EPA06414.1 - 1.2e-06 28.5 11.3 0.0002 21.5 0.4 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 EPA06414.1 - 7.6e-05 22.4 14.7 0.00018 21.2 3.1 2.4 2 1 0 2 2 2 1 C2H2-type zinc finger zinc_ribbon_5 PF13719.1 EPA06414.1 - 0.00011 21.7 3.8 0.016 14.7 0.2 2.3 2 0 0 2 2 2 2 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA06414.1 - 0.00083 19.0 5.1 0.051 13.2 0.4 2.4 2 0 0 2 2 2 2 zinc-ribbon domain RNA_POL_M_15KD PF02150.11 EPA06414.1 - 0.003 17.2 2.6 0.2 11.3 0.2 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit XPA_N PF01286.13 EPA06414.1 - 0.0039 16.8 3.3 0.89 9.2 0.1 2.3 2 0 0 2 2 2 2 XPA protein N-terminal zf-H2C2_2 PF13465.1 EPA06414.1 - 0.0042 17.3 14.4 0.2 12.0 0.7 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-trcl PF13451.1 EPA06414.1 - 0.0047 16.5 3.4 0.84 9.3 0.0 2.3 2 1 0 2 2 2 2 Probable zinc-binding domain DUF678 PF05077.7 EPA06414.1 - 0.0077 16.1 3.5 0.57 10.2 0.1 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF678) DNA_RNApol_7kD PF03604.8 EPA06414.1 - 0.013 14.8 3.9 0.17 11.3 0.3 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-DNA_Pol PF08996.5 EPA06414.1 - 0.015 14.6 3.4 0.018 14.3 2.4 1.3 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger Prok-RING_1 PF14446.1 EPA06414.1 - 0.02 14.5 5.7 0.57 9.9 0.9 2.4 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 zf-C2H2_2 PF12756.2 EPA06414.1 - 0.026 14.6 7.4 1.2 9.2 1.9 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) ADK_lid PF05191.9 EPA06414.1 - 0.029 14.0 2.2 2.8 7.6 0.2 2.3 2 0 0 2 2 2 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.5 EPA06414.1 - 0.033 14.1 8.4 0.13 12.1 4.5 2.3 1 1 0 1 1 1 0 Zinc ribbon domain FYVE PF01363.16 EPA06414.1 - 0.034 14.0 10.9 0.048 13.5 4.7 2.0 1 1 1 2 2 2 0 FYVE zinc finger PhnA_Zn_Ribbon PF08274.7 EPA06414.1 - 0.037 13.8 1.6 1.3 8.9 0.1 2.2 2 0 0 2 2 2 0 PhnA Zinc-Ribbon CpXC PF14353.1 EPA06414.1 - 0.043 13.7 2.5 1.4 8.8 0.1 2.1 1 1 1 2 2 2 0 CpXC protein zf-CSL PF05207.8 EPA06414.1 - 0.055 12.9 3.7 3 7.4 0.1 2.1 1 1 1 2 2 2 0 CSL zinc finger TFIIS_C PF01096.13 EPA06414.1 - 0.074 12.6 3.2 0.67 9.6 0.1 2.4 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) DZR PF12773.2 EPA06414.1 - 0.11 12.3 7.1 0.18 11.6 4.9 1.5 1 1 0 1 1 1 0 Double zinc ribbon HypA PF01155.14 EPA06414.1 - 0.13 11.9 6.3 0.27 10.9 2.7 1.9 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Antimicrobial_6 PF08036.6 EPA06414.1 - 0.17 11.6 2.1 0.19 11.5 0.3 1.9 2 0 0 2 2 2 0 Diapausin family of antimicrobial peptide GCC2_GCC3 PF07699.8 EPA06414.1 - 0.18 11.3 8.1 2.6 7.6 1.9 2.2 1 1 1 2 2 2 0 GCC2 and GCC3 DUF2318 PF10080.4 EPA06414.1 - 0.2 11.4 2.6 1.6 8.5 0.1 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) C1_1 PF00130.17 EPA06414.1 - 0.23 11.2 6.8 0.84 9.4 4.7 1.9 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) GFA PF04828.9 EPA06414.1 - 0.31 11.0 4.5 2.4 8.1 0.4 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Bunya_G2 PF03563.8 EPA06414.1 - 0.32 9.8 2.9 2.4 6.9 2.0 1.9 1 1 0 1 1 1 0 Bunyavirus glycoprotein G2 zf-CHY PF05495.7 EPA06414.1 - 0.44 10.7 9.4 1.1 9.5 6.5 1.6 1 1 0 1 1 1 0 CHY zinc finger Rpr2 PF04032.11 EPA06414.1 - 0.5 10.2 7.7 1.6 8.6 3.6 2.0 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-HYPF PF07503.7 EPA06414.1 - 0.53 9.7 5.9 6 6.3 0.2 2.4 2 0 0 2 2 2 0 HypF finger zf-BED PF02892.10 EPA06414.1 - 0.73 9.6 15.7 2 8.2 1.5 2.2 1 1 1 2 2 2 0 BED zinc finger zf-C3HC PF07967.8 EPA06414.1 - 0.79 9.4 5.9 1 9.1 4.1 1.2 1 0 0 1 1 1 0 C3HC zinc finger-like TF_Zn_Ribbon PF08271.7 EPA06414.1 - 0.86 8.9 5.3 2.8 7.3 0.1 2.4 3 0 0 3 3 2 0 TFIIB zinc-binding Zn_ribbon_recom PF13408.1 EPA06414.1 - 1.1 9.5 9.7 13 6.1 6.8 2.1 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain zf-ribbon_3 PF13248.1 EPA06414.1 - 1.2 8.4 5.5 9.4 5.5 0.1 2.4 2 1 0 2 2 2 0 zinc-ribbon domain zf-CHCC PF10276.4 EPA06414.1 - 1.2 8.9 4.8 7.3 6.5 0.1 2.5 3 0 0 3 3 2 0 Zinc-finger domain OrfB_Zn_ribbon PF07282.6 EPA06414.1 - 1.3 8.7 7.9 7.4 6.3 0.3 2.1 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zf-C2HC_2 PF13913.1 EPA06414.1 - 1.8 8.3 16.0 1.8 8.3 4.4 2.6 1 1 1 2 2 2 0 zinc-finger of a C2HC-type SAE2 PF08573.5 EPA06414.1 - 2.3 9.0 6.8 29 5.4 4.7 2.0 1 1 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus SprT-like PF10263.4 EPA06414.1 - 2.3 7.8 7.2 7.6 6.1 5.0 1.7 1 1 0 1 1 1 0 SprT-like family COX5B PF01215.14 EPA06414.1 - 2.5 7.7 5.5 9.3 5.9 0.4 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase subunit Vb zf-CCHC PF00098.18 EPA06414.1 - 2.9 7.9 9.8 2 8.4 0.2 3.0 3 0 0 3 3 3 0 Zinc knuckle DUF4379 PF14311.1 EPA06414.1 - 4.8 7.0 10.3 1.8 8.4 2.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4379) zf-C2H2_3 PF13878.1 EPA06414.1 - 5.6 6.6 7.9 13 5.4 0.1 2.6 2 1 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO YhfH PF14149.1 EPA06414.1 - 7 6.5 10.7 17 5.2 3.0 2.5 2 1 0 2 2 2 0 YhfH-like protein DM PF00751.13 EPA06414.1 - 8.1 6.0 15.7 4.4 6.8 5.0 2.2 2 0 0 2 2 2 0 DM DNA binding domain Zn_Tnp_IS1595 PF12760.2 EPA06414.1 - 8.4 6.2 9.1 21 5.0 4.6 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 EPA06415.1 - 0.0015 18.1 1.2 0.0018 17.9 0.8 1.1 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Zn_Tnp_IS1595 PF12760.2 EPA06415.1 - 0.025 14.3 0.9 0.031 14.0 0.6 1.1 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Desulfoferrod_N PF06397.7 EPA06415.1 - 0.03 13.6 1.2 0.34 10.3 0.0 2.1 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain A2L_zn_ribbon PF08792.5 EPA06415.1 - 0.044 13.2 4.0 2 7.9 0.2 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain Rubredoxin PF00301.15 EPA06415.1 - 0.073 12.9 1.0 1.5 8.7 0.1 2.1 2 0 0 2 2 2 0 Rubredoxin zf-LITAF-like PF10601.4 EPA06415.1 - 0.074 12.9 2.9 1.3 8.9 0.3 2.0 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain C1_4 PF07975.7 EPA06415.1 - 0.12 12.4 1.3 0.13 12.2 0.9 1.1 1 0 0 1 1 1 0 TFIIH C1-like domain RecR PF02132.10 EPA06415.1 - 0.13 11.7 2.4 1.6 8.2 0.1 2.2 2 0 0 2 2 2 0 RecR protein Ima1_N PF09779.4 EPA06415.1 - 0.13 12.7 2.5 0.15 12.5 1.7 1.2 1 0 0 1 1 1 0 Ima1 N-terminal domain Zn-ribbon_8 PF09723.5 EPA06415.1 - 0.13 12.1 1.9 0.31 11.0 1.3 1.6 1 1 0 1 1 1 0 Zinc ribbon domain Elf1 PF05129.8 EPA06415.1 - 0.31 10.7 2.8 1.8 8.2 0.2 1.7 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like Tnp_zf-ribbon_2 PF13842.1 EPA06415.1 - 0.34 11.3 4.0 0.59 10.5 2.8 1.5 1 1 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon C1_1 PF00130.17 EPA06415.1 - 0.4 10.4 2.9 0.93 9.2 2.0 1.6 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RanBP PF00641.13 EPA06415.1 - 0.43 9.7 8.5 0.32 10.1 0.7 2.2 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others RNA_POL_M_15KD PF02150.11 EPA06415.1 - 0.57 9.9 0.2 0.57 9.9 0.1 2.1 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit zf-BED PF02892.10 EPA06415.1 - 0.91 9.3 3.9 1.2 8.9 0.1 2.1 1 1 1 2 2 2 0 BED zinc finger DUF3797 PF12677.2 EPA06415.1 - 2.2 7.9 6.8 5.5 6.7 0.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) FlgD_ig PF13860.1 EPA06416.1 - 0.097 12.4 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 FlgD Ig-like domain DUF4002 PF13164.1 EPA06417.1 - 0.0074 16.2 2.7 0.0074 16.2 1.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4002) Elf1 PF05129.8 EPA06417.1 - 0.044 13.4 6.0 0.046 13.4 4.2 1.1 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zf-B_box PF00643.19 EPA06417.1 - 0.057 13.3 12.3 0.12 12.2 8.5 1.6 1 1 0 1 1 1 0 B-box zinc finger zinc-ribbons_6 PF07191.7 EPA06417.1 - 0.11 12.2 8.6 0.089 12.5 5.3 1.4 1 1 0 1 1 1 0 zinc-ribbons FYVE PF01363.16 EPA06417.1 - 0.13 12.1 5.9 0.12 12.2 4.1 1.1 1 0 0 1 1 1 0 FYVE zinc finger DZR PF12773.2 EPA06417.1 - 0.17 11.7 10.7 0.32 10.8 7.4 1.6 1 1 0 1 1 1 0 Double zinc ribbon Tnp_zf-ribbon_2 PF13842.1 EPA06417.1 - 0.29 11.5 10.6 0.09 13.1 2.8 2.2 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Cript PF10235.4 EPA06417.1 - 0.87 9.9 6.6 1.1 9.6 4.6 1.2 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT zf-HIT PF04438.11 EPA06417.1 - 1.7 8.3 6.5 0.72 9.5 0.9 2.3 2 0 0 2 2 2 0 HIT zinc finger Stc1 PF12898.2 EPA06417.1 - 3 7.9 9.9 1.8 8.6 5.3 1.6 1 1 1 2 2 2 0 Stc1 domain ATP-grasp_5 PF13549.1 EPA06418.1 - 0.031 13.4 0.5 0.076 12.2 0.0 1.7 2 0 0 2 2 2 0 ATP-grasp domain Guanylate_cyc PF00211.15 EPA06419.1 - 2e-09 37.0 0.0 2.3e-09 36.8 0.0 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PDT PF00800.13 EPA06422.1 - 1.3e-39 135.6 0.0 1.4e-39 135.5 0.0 1.0 1 0 0 1 1 1 1 Prephenate dehydratase Prok-RING_1 PF14446.1 EPA06423.1 - 0.00063 19.4 1.6 0.00086 18.9 1.1 1.1 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 NB PF04159.8 EPA06423.1 - 0.029 14.1 0.1 0.031 14.0 0.1 1.1 1 0 0 1 1 1 0 NB glycoprotein Ribosomal_L37e PF01907.14 EPA06423.1 - 0.046 13.5 0.3 0.057 13.2 0.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L37e DNA_RNApol_7kD PF03604.8 EPA06423.1 - 0.089 12.2 6.4 0.28 10.6 4.4 1.8 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Nudix_N_2 PF14803.1 EPA06423.1 - 0.58 9.8 3.0 3.9 7.2 0.1 2.2 2 0 0 2 2 2 0 Nudix N-terminal YhfH PF14149.1 EPA06423.1 - 1.9 8.3 4.7 6.5 6.6 3.3 1.8 1 1 1 2 2 2 0 YhfH-like protein Zn-ribbon_8 PF09723.5 EPA06423.1 - 4.5 7.3 5.5 4 7.4 0.4 2.0 1 1 0 1 1 1 0 Zinc ribbon domain DUF1510 PF07423.6 EPA06424.1 - 0.0035 16.7 0.1 0.0039 16.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) PhoU_div PF01865.11 EPA06425.1 - 2e-19 69.6 11.4 2.3e-19 69.3 7.9 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF47 PhoU PF01895.14 EPA06425.1 - 0.0029 17.9 13.9 0.013 15.9 1.9 3.0 2 2 2 4 4 4 2 PhoU domain LXG PF04740.7 EPA06425.1 - 0.017 14.8 6.7 0.032 14.0 0.3 2.5 1 1 1 2 2 2 0 LXG domain of WXG superfamily TerB PF05099.8 EPA06425.1 - 0.09 12.5 0.6 0.27 10.9 0.1 2.0 2 1 0 2 2 2 0 Tellurite resistance protein TerB DUF458 PF04308.7 EPA06425.1 - 0.14 11.8 5.0 0.29 10.8 1.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF458) MCPsignal PF00015.16 EPA06425.1 - 0.2 11.1 11.3 5.5 6.4 6.7 3.0 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Laminin_I PF06008.9 EPA06425.1 - 0.22 10.8 7.4 0.048 12.9 0.6 2.5 1 1 1 2 2 2 0 Laminin Domain I Reo_sigmaC PF04582.7 EPA06425.1 - 0.37 9.9 3.0 0.94 8.5 0.7 1.8 1 1 1 2 2 2 0 Reovirus sigma C capsid protein tRNA-synt_2 PF00152.15 EPA06426.1 - 1.4e-88 296.9 0.0 2.1e-88 296.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EPA06426.1 - 9.2e-12 44.6 1.0 1.7e-11 43.7 0.7 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 EPA06426.1 - 0.0081 15.3 0.1 0.12 11.5 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) Memo PF01875.12 EPA06427.1 - 0.011 14.6 0.3 0.017 14.0 0.2 1.4 1 1 0 1 1 1 0 Memo-like protein BioW PF03744.8 EPA06427.1 - 0.032 13.6 0.1 0.033 13.6 0.1 1.2 1 0 0 1 1 1 0 6-carboxyhexanoate--CoA ligase DUF553 PF04473.7 EPA06427.1 - 0.035 13.3 1.2 0.037 13.2 0.3 1.4 1 1 0 1 1 1 0 Transglutaminase-like domain Prp18 PF02840.10 EPA06427.1 - 0.081 12.7 2.9 0.11 12.2 2.0 1.2 1 0 0 1 1 1 0 Prp18 domain AraC_N PF06719.8 EPA06427.1 - 0.088 12.1 0.1 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 AraC-type transcriptional regulator N-terminus Med4 PF10018.4 EPA06427.1 - 0.46 9.8 4.0 0.52 9.6 2.8 1.1 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Transposase_22 PF02994.9 EPA06427.1 - 0.54 8.6 9.5 0.55 8.6 6.6 1.1 1 0 0 1 1 1 0 L1 transposable element SAP PF02037.22 EPA06427.1 - 0.64 9.6 3.0 24 4.5 0.1 3.1 3 1 0 3 3 3 0 SAP domain DUF1884 PF08967.5 EPA06427.1 - 0.7 9.9 3.4 0.56 10.2 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1884) End3 PF12761.2 EPA06427.1 - 1.7 8.2 6.6 1.9 8.0 4.5 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Med21 PF11221.3 EPA06427.1 - 2.1 8.3 5.4 4 7.4 3.7 1.6 1 1 0 1 1 1 0 Subunit 21 of Mediator complex DUF2296 PF10058.4 EPA06428.1 - 0.0006 19.4 0.7 0.00066 19.3 0.5 1.1 1 0 0 1 1 1 1 Predicted integral membrane metal-binding protein (DUF2296) DUF4379 PF14311.1 EPA06428.1 - 0.011 15.5 0.7 0.16 11.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4379) Auto_anti-p27 PF06677.7 EPA06428.1 - 0.017 14.8 2.1 0.028 14.1 1.4 1.3 1 1 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) IBR PF01485.16 EPA06428.1 - 0.033 14.0 0.8 0.037 13.8 0.5 1.0 1 0 0 1 1 1 0 IBR domain zf-RING_3 PF14369.1 EPA06428.1 - 0.049 13.6 2.6 1.1 9.2 0.1 2.0 1 1 1 2 2 2 0 zinc-finger zf-C4_Topoisom PF01396.14 EPA06428.1 - 0.054 13.0 1.2 0.93 9.0 0.0 2.1 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zinc-ribbons_6 PF07191.7 EPA06428.1 - 0.057 13.2 0.2 0.073 12.8 0.2 1.2 1 0 0 1 1 1 0 zinc-ribbons zf-TFIIB PF13453.1 EPA06428.1 - 0.066 12.4 1.5 1.6 8.0 0.1 2.1 2 0 0 2 2 2 0 Transcription factor zinc-finger PhnA_Zn_Ribbon PF08274.7 EPA06428.1 - 0.13 12.0 2.2 7.5 6.4 0.1 2.1 2 0 0 2 2 2 0 PhnA Zinc-Ribbon zf-met PF12874.2 EPA06428.1 - 0.13 12.5 0.8 0.19 11.9 0.5 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Prok-RING_1 PF14446.1 EPA06428.1 - 0.19 11.4 1.5 9 6.1 0.1 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 DZR PF12773.2 EPA06428.1 - 0.23 11.3 2.0 0.52 10.1 1.4 1.6 1 1 0 1 1 1 0 Double zinc ribbon zf-H2C2_2 PF13465.1 EPA06428.1 - 0.23 11.8 4.3 0.63 10.4 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger double domain RNA_POL_M_15KD PF02150.11 EPA06428.1 - 0.24 11.0 2.8 2.8 7.6 0.7 2.1 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit PHD PF00628.24 EPA06428.1 - 0.29 10.8 2.8 0.53 10.0 2.0 1.5 1 1 0 1 1 1 0 PHD-finger zf-C2H2 PF00096.21 EPA06428.1 - 0.48 10.8 3.3 5.1 7.6 0.3 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type RecR PF02132.10 EPA06428.1 - 0.56 9.6 2.9 4.1 6.9 2.0 2.0 1 1 0 1 1 1 0 RecR protein zf-RanBP PF00641.13 EPA06428.1 - 0.74 8.9 6.0 0.78 8.8 0.5 2.1 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Rubredoxin PF00301.15 EPA06428.1 - 1.4 8.8 6.2 0.41 10.5 0.4 2.1 1 1 1 2 2 2 0 Rubredoxin zf-C2H2_4 PF13894.1 EPA06428.1 - 1.6 9.2 4.2 12 6.5 0.5 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-MIZ PF02891.15 EPA06428.1 - 2.7 7.5 5.8 8.7 5.9 4.1 1.7 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger zf-C2HC_2 PF13913.1 EPA06428.1 - 7.7 6.3 6.7 9.6 5.9 0.5 2.1 2 0 0 2 2 2 0 zinc-finger of a C2HC-type ABC_tran PF00005.22 EPA06430.1 - 3.9e-26 91.9 0.0 5.3e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.7 EPA06430.1 - 1.5e-18 66.8 0.3 2.5e-18 66.1 0.2 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.1 EPA06430.1 - 6.1e-11 42.8 1.5 4.3e-09 36.7 1.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 EPA06430.1 - 0.001 18.5 1.0 0.066 12.6 0.0 2.2 1 1 0 2 2 2 1 AAA-like domain AAA_18 PF13238.1 EPA06430.1 - 0.0022 18.3 0.2 0.0056 16.9 0.1 1.9 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 EPA06430.1 - 0.0045 16.2 0.4 0.0082 15.3 0.3 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_13 PF13166.1 EPA06430.1 - 0.01 14.3 0.1 2.6 6.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 EPA06430.1 - 0.06 12.7 0.1 0.14 11.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 EPA06430.1 - 0.061 12.8 0.1 0.13 11.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.1 EPA06430.1 - 0.084 11.8 0.7 0.19 10.7 0.3 1.7 1 1 1 2 2 2 0 AAA ATPase domain PRK PF00485.13 EPA06430.1 - 0.098 12.1 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family RNA_pol_Rbc25 PF08292.7 EPA06431.1 - 0.0062 16.7 0.3 0.045 13.9 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase III subunit Rpc25 DUF897 PF05982.7 EPA06434.1 - 1.6e-91 306.4 21.2 1.9e-91 306.2 14.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF897) NfeD PF01957.13 EPA06434.1 - 0.24 11.5 0.0 0.24 11.5 0.0 3.4 2 2 0 3 3 3 0 NfeD-like C-terminal, partner-binding DUF4006 PF13179.1 EPA06434.1 - 0.39 10.3 4.7 3.5 7.2 1.5 3.0 2 0 0 2 2 2 0 Family of unknown function (DUF4006) EF1_GNE PF00736.14 EPA06435.1 - 0.049 13.3 0.2 0.067 12.8 0.2 1.2 1 0 0 1 1 1 0 EF-1 guanine nucleotide exchange domain DNA_ligase_A_M PF01068.16 EPA06436.1 - 2.3e-59 200.1 0.8 4.9e-59 199.0 0.5 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EPA06436.1 - 1.3e-50 171.6 2.4 3.1e-50 170.4 1.7 1.7 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 EPA06436.1 - 2.2e-21 76.0 0.0 4.9e-21 74.9 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.1 EPA06436.1 - 0.11 12.2 0.1 0.48 10.1 0.0 2.1 2 0 0 2 2 2 0 DNA ligase OB-like domain WGG PF10273.4 EPA06436.1 - 0.11 12.5 0.1 0.96 9.5 0.0 2.5 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 T2SE PF00437.15 EPA06437.1 - 4.6e-13 48.6 0.0 9.1e-13 47.7 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein KH_1 PF00013.24 EPA06437.1 - 2.7e-09 36.5 0.1 1.9e-08 33.7 0.0 2.5 2 0 0 2 2 2 1 KH domain KH_2 PF07650.12 EPA06437.1 - 3.2e-08 33.0 0.0 1.7e-07 30.7 0.0 2.3 1 0 0 1 1 1 1 KH domain AAA_14 PF13173.1 EPA06437.1 - 7.7e-07 29.0 0.1 3e-05 23.9 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_17 PF13207.1 EPA06437.1 - 2.1e-06 28.5 0.0 8.9e-06 26.5 0.0 2.1 1 0 0 1 1 1 1 AAA domain KH_3 PF13014.1 EPA06437.1 - 6.9e-06 25.5 0.1 6.1e-05 22.5 0.0 2.5 2 0 0 2 2 2 1 KH domain PIN_4 PF13638.1 EPA06437.1 - 2.6e-05 24.3 0.3 0.00022 21.3 0.2 2.5 1 1 0 1 1 1 1 PIN domain AAA_18 PF13238.1 EPA06437.1 - 3.3e-05 24.1 0.7 0.00026 21.3 0.0 2.9 4 0 0 4 4 3 1 AAA domain KH_5 PF13184.1 EPA06437.1 - 9.3e-05 22.1 2.1 0.00074 19.2 0.3 3.0 2 0 0 2 2 2 1 NusA-like KH domain KH_4 PF13083.1 EPA06437.1 - 0.00024 20.6 0.2 0.00074 19.1 0.1 1.9 1 0 0 1 1 1 1 KH domain AAA_22 PF13401.1 EPA06437.1 - 0.00037 20.6 0.2 0.0074 16.4 0.0 2.8 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.1 EPA06437.1 - 0.00046 20.2 0.0 0.0019 18.1 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.12 EPA06437.1 - 0.00066 19.1 0.0 0.0014 18.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.1 EPA06437.1 - 0.00076 18.9 0.0 0.0022 17.4 0.0 1.8 2 0 0 2 2 1 1 AAA domain ArgK PF03308.11 EPA06437.1 - 0.00079 18.2 0.0 0.004 15.9 0.0 2.0 2 0 0 2 2 2 1 ArgK protein AAA_19 PF13245.1 EPA06437.1 - 0.00094 18.8 0.0 0.002 17.8 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain ABC_tran PF00005.22 EPA06437.1 - 0.0035 17.6 0.0 0.016 15.5 0.0 2.1 2 0 0 2 2 1 1 ABC transporter AAA_10 PF12846.2 EPA06437.1 - 0.0035 16.8 0.0 0.031 13.7 0.0 2.1 2 0 0 2 2 2 1 AAA-like domain AAA PF00004.24 EPA06437.1 - 0.0058 16.8 0.1 0.08 13.1 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EPA06437.1 - 0.0074 16.1 0.0 0.024 14.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_28 PF13521.1 EPA06437.1 - 0.0084 16.0 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EPA06437.1 - 0.012 15.1 0.0 0.034 13.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.9 EPA06437.1 - 0.017 14.8 0.0 0.04 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.10 EPA06437.1 - 0.018 14.7 0.0 0.079 12.6 0.0 2.2 1 0 0 1 1 1 0 NTPase Zeta_toxin PF06414.7 EPA06437.1 - 0.03 13.4 0.0 0.086 11.9 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin NACHT PF05729.7 EPA06437.1 - 0.031 13.9 0.0 0.098 12.3 0.0 1.9 1 0 0 1 1 1 0 NACHT domain KTI12 PF08433.5 EPA06437.1 - 0.036 13.2 0.0 0.085 12.0 0.0 1.6 1 0 0 1 1 1 0 Chromatin associated protein KTI12 RNA_helicase PF00910.17 EPA06437.1 - 0.044 13.9 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.1 EPA06437.1 - 0.05 13.1 0.1 0.12 11.9 0.0 1.6 2 0 0 2 2 1 0 AAA domain NB-ARC PF00931.17 EPA06437.1 - 0.052 12.3 0.0 0.27 10.0 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain Mg_chelatase PF01078.16 EPA06437.1 - 0.11 11.7 0.0 0.28 10.3 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.13 EPA06437.1 - 0.13 11.8 0.0 0.27 10.6 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.1 EPA06437.1 - 0.17 12.2 3.2 0.53 10.5 0.0 2.9 3 1 0 3 3 3 0 AAA domain M157 PF11624.3 EPA06438.1 - 0.11 11.5 0.1 0.12 11.4 0.1 1.1 1 0 0 1 1 1 0 MHC class I-like protein M157 Pur_DNA_glyco PF02245.11 EPA06441.1 - 3.8e-65 218.4 0.0 4.2e-65 218.3 0.0 1.0 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) adh_short PF00106.20 EPA06442.1 - 1.1e-26 93.7 0.0 1e-20 74.3 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.1 EPA06442.1 - 1e-13 51.6 0.6 2.2e-09 37.4 0.0 3.6 4 0 0 4 4 4 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EPA06442.1 - 2.7e-12 46.7 0.0 1.6e-09 37.6 0.0 2.4 2 0 0 2 2 2 2 KR domain Epimerase PF01370.16 EPA06442.1 - 4.4e-08 32.8 0.0 2.8e-06 26.9 0.0 2.3 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EPA06442.1 - 0.014 15.3 0.1 0.16 11.9 0.0 2.7 2 1 0 2 2 2 0 NADH(P)-binding Polysacc_synt_2 PF02719.10 EPA06442.1 - 0.018 13.9 0.1 0.036 12.9 0.1 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein F420_oxidored PF03807.12 EPA06442.1 - 0.06 13.7 0.6 0.24 11.8 0.2 2.3 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent SNARE_assoc PF09335.6 EPA06443.1 - 8.2e-17 61.5 0.9 8.2e-17 61.5 0.6 2.0 2 1 0 2 2 2 1 SNARE associated Golgi protein DUF1418 PF07214.7 EPA06443.1 - 0.043 13.4 1.9 0.09 12.4 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) DUF697 PF05128.7 EPA06443.1 - 0.051 13.0 0.0 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF697) Glycophorin_A PF01102.13 EPA06443.1 - 0.093 12.5 1.0 6.8 6.4 0.0 2.2 2 0 0 2 2 2 0 Glycophorin A zf-DHHC PF01529.15 EPA06443.1 - 0.2 11.0 2.3 0.14 11.5 0.4 1.6 2 0 0 2 2 2 0 DHHC palmitoyltransferase MFS_1 PF07690.11 EPA06443.1 - 1.5 7.4 9.6 3.3 6.3 6.6 1.6 1 1 0 1 1 1 0 Major Facilitator Superfamily DUF1700 PF08006.6 EPA06443.1 - 6.6 5.9 9.7 0.52 9.5 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) TauE PF01925.14 EPA06444.1 - 5.4e-50 170.0 34.6 6.7e-50 169.7 24.0 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE PMP22_Claudin PF00822.15 EPA06444.1 - 0.29 10.7 5.2 0.072 12.7 1.0 2.0 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family DUF3353 PF11833.3 EPA06444.1 - 8 5.8 16.7 0.31 10.4 2.7 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3353) Sugar_tr PF00083.19 EPA06446.1 - 1.5e-34 119.3 32.8 7.2e-26 90.7 7.7 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 EPA06446.1 - 7.8e-34 116.9 35.1 7.8e-34 116.9 24.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.1 EPA06446.1 - 1.8e-07 29.9 24.2 5.3e-07 28.3 6.3 2.5 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.2 EPA06446.1 - 2e-05 24.2 7.2 0.00011 21.8 0.6 3.3 2 1 1 3 3 3 2 MFS_1 like family ATG22 PF11700.3 EPA06446.1 - 0.00015 20.3 7.4 0.00015 20.3 5.1 2.7 2 2 0 2 2 2 1 Vacuole effluxer Atg22 like DUF2874 PF11396.3 EPA06447.1 - 0.12 12.3 0.2 0.2 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2874) Reprolysin_2 PF13574.1 EPA06448.1 - 4e-05 23.7 0.0 6.7e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.19 EPA06448.1 - 0.00042 20.0 1.7 0.0063 16.2 1.2 2.5 1 1 0 1 1 1 1 Matrixin Peptidase_M43 PF05572.8 EPA06448.1 - 0.00046 19.8 0.0 0.00099 18.7 0.0 1.6 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Peptidase_M66 PF10462.4 EPA06448.1 - 0.00067 18.6 0.1 0.0013 17.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase M66 Reprolysin_4 PF13583.1 EPA06448.1 - 0.0019 17.7 0.0 0.0029 17.1 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 EPA06448.1 - 0.0057 16.6 0.2 0.01 15.7 0.1 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.1 EPA06448.1 - 0.0074 16.8 0.2 0.019 15.4 0.1 1.9 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.6 EPA06448.1 - 0.012 15.4 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M54 Astacin PF01400.19 EPA06448.1 - 0.04 13.3 0.7 0.12 11.7 0.5 1.7 1 1 0 1 1 1 0 Astacin (Peptidase family M12A) Peptidase_M57 PF12388.3 EPA06448.1 - 0.044 13.1 0.0 0.081 12.2 0.0 1.5 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase DUF1025 PF06262.6 EPA06448.1 - 0.097 12.4 0.2 0.31 10.8 0.1 1.8 1 1 0 1 1 1 0 Possibl zinc metallo-peptidase DUF192 PF02643.10 EPA06450.1 - 4.3e-30 103.5 0.0 5.3e-30 103.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, COG1430 Fe_dep_repress PF01325.14 EPA06451.1 - 4.9e-18 64.8 2.3 7.7e-18 64.1 1.6 1.3 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain Fe_dep_repr_C PF02742.10 EPA06451.1 - 1.5e-16 59.8 0.1 2.8e-16 58.9 0.1 1.4 1 0 0 1 1 1 1 Iron dependent repressor, metal binding and dimerisation domain DUF4423 PF14394.1 EPA06451.1 - 5.1e-05 22.8 0.3 0.00039 19.9 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4423) HTH_27 PF13463.1 EPA06451.1 - 5.3e-05 23.4 0.0 0.00022 21.4 0.0 2.0 2 1 0 2 2 2 1 Winged helix DNA-binding domain MarR_2 PF12802.2 EPA06451.1 - 6.1e-05 22.6 0.0 0.0001 21.9 0.0 1.3 1 0 0 1 1 1 1 MarR family TrmB PF01978.14 EPA06451.1 - 0.00011 21.8 0.2 0.00022 20.8 0.2 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 EPA06451.1 - 0.00021 20.6 0.1 0.00047 19.4 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding DUF2250 PF10007.4 EPA06451.1 - 0.00023 21.0 0.4 0.00047 20.0 0.2 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2250) MarR PF01047.17 EPA06451.1 - 0.00033 20.3 0.1 0.00096 18.8 0.0 1.8 2 0 0 2 2 2 1 MarR family HTH_Crp_2 PF13545.1 EPA06451.1 - 0.00089 19.0 0.0 0.0034 17.1 0.0 1.9 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_45 PF14947.1 EPA06451.1 - 0.0009 19.0 1.0 0.0024 17.6 0.6 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix HTH_12 PF08461.5 EPA06451.1 - 0.0024 17.5 0.1 0.0051 16.5 0.1 1.6 1 1 0 1 1 1 1 Ribonuclease R winged-helix domain TFIIE_alpha PF02002.12 EPA06451.1 - 0.0096 15.4 0.3 0.039 13.4 0.1 1.9 1 1 1 2 2 2 1 TFIIE alpha subunit LexA_DNA_bind PF01726.11 EPA06451.1 - 0.011 15.2 0.0 0.03 13.8 0.0 1.7 2 0 0 2 2 2 0 LexA DNA binding domain HTH_1 PF00126.22 EPA06451.1 - 0.02 14.5 0.0 0.057 13.1 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family Ribosomal_S19e PF01090.14 EPA06451.1 - 0.033 13.6 0.0 0.061 12.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S19e FeoC PF09012.5 EPA06451.1 - 0.035 13.8 0.0 0.067 12.9 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator Rrf2 PF02082.15 EPA06451.1 - 0.057 13.5 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator HTH_IclR PF09339.5 EPA06451.1 - 0.063 12.8 0.0 0.095 12.3 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain GntR PF00392.16 EPA06451.1 - 0.064 12.7 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family DUF4358 PF14270.1 EPA06451.1 - 0.094 12.6 0.3 0.25 11.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) Rio2_N PF09202.6 EPA06451.1 - 0.095 12.7 0.1 0.2 11.7 0.1 1.6 1 1 0 1 1 1 0 Rio2, N-terminal HTH_28 PF13518.1 EPA06451.1 - 0.12 12.3 0.0 1.3 9.0 0.0 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain P-II PF00543.17 EPA06452.1 - 0.0013 19.1 0.0 0.0019 18.6 0.0 1.2 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DUF3240 PF11582.3 EPA06452.1 - 0.0017 18.2 0.0 0.0059 16.5 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3240) Nit_Regul_Hom PF10126.4 EPA06452.1 - 0.013 15.2 0.4 0.045 13.5 0.3 1.7 1 1 1 2 2 2 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII DUF190 PF02641.10 EPA06452.1 - 0.017 15.0 0.3 0.021 14.6 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized ACR, COG1993 Claudin_2 PF13903.1 EPA06453.1 - 0.00021 21.0 1.8 0.00023 20.8 1.3 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.1 EPA06453.1 - 0.0038 17.2 5.0 0.0038 17.2 3.5 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF4064) DUF981 PF06168.6 EPA06453.1 - 0.016 15.0 1.1 0.02 14.7 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF981) PEMT PF04191.8 EPA06453.1 - 0.049 13.7 0.4 0.049 13.7 0.3 1.9 1 1 1 2 2 2 0 Phospholipid methyltransferase ABC2_membrane_3 PF12698.2 EPA06453.1 - 0.11 11.5 8.5 0.12 11.4 5.9 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein SUR7 PF06687.7 EPA06453.1 - 0.18 11.3 2.7 0.22 11.0 1.9 1.1 1 0 0 1 1 1 0 SUR7/PalI family MgtE PF01769.11 EPA06453.1 - 2.4 8.4 9.1 0.37 11.0 3.8 1.4 2 0 0 2 2 2 0 Divalent cation transporter DUF2929 PF11151.3 EPA06453.1 - 4.1 7.5 8.3 14 5.8 0.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2929) DUF2721 PF11026.3 EPA06453.1 - 4.7 6.8 6.9 7.4 6.2 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) UDG PF03167.14 EPA06457.1 - 7e-34 116.4 0.0 9.1e-34 116.1 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Epimerase_2 PF02350.14 EPA06457.1 - 0.074 11.8 0.0 0.13 11.0 0.0 1.3 1 1 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase Spore_GerAC PF05504.6 EPA06459.1 - 0.33 10.6 6.0 0.16 11.7 2.0 1.8 1 1 1 2 2 2 0 Spore germination B3/ GerAC like, C-terminal HATPase_c PF02518.21 EPA06460.1 - 1.3e-26 92.5 0.1 2.5e-26 91.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EPA06460.1 - 1.4e-15 57.0 0.1 3.4e-15 55.7 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.20 EPA06460.1 - 3.1e-08 33.6 0.1 3.1e-08 33.6 0.0 3.0 4 0 0 4 4 4 1 HAMP domain HATPase_c_3 PF13589.1 EPA06460.1 - 4.3e-05 23.2 0.3 0.00019 21.0 0.1 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 EPA06460.1 - 0.047 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain KH_5 PF13184.1 EPA06462.1 - 6.7e-08 32.2 0.0 1.4e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 NusA-like KH domain Ribosomal_S2 PF00318.15 EPA06462.1 - 0.0034 16.6 2.1 0.0041 16.3 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein S2 Hpt PF01627.18 EPA06463.1 - 2.1e-06 27.6 0.0 2.8e-06 27.2 0.0 1.3 1 1 0 1 1 1 1 Hpt domain Lip_prot_lig_C PF10437.4 EPA06463.1 - 0.024 14.2 0.5 0.042 13.5 0.1 1.6 2 0 0 2 2 2 0 Bacterial lipoate protein ligase C-terminus DHC_N2 PF08393.8 EPA06463.1 - 0.029 12.8 1.5 0.71 8.3 0.0 2.0 1 1 1 2 2 2 0 Dynein heavy chain, N-terminal region 2 Seryl_tRNA_N PF02403.17 EPA06463.1 - 0.031 14.3 1.9 0.039 13.9 0.2 1.9 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Tweety PF04906.8 EPA06463.1 - 0.031 12.7 0.5 0.034 12.5 0.4 1.1 1 0 0 1 1 1 0 Tweety Syntaxin-6_N PF09177.6 EPA06463.1 - 0.041 14.2 0.9 1 9.8 0.3 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Syntaxin PF00804.20 EPA06463.1 - 0.046 13.8 5.3 0.14 12.3 0.1 2.9 2 1 0 2 2 2 0 Syntaxin Snf7 PF03357.16 EPA06463.1 - 0.047 13.0 1.5 0.066 12.5 0.3 1.7 2 0 0 2 2 2 0 Snf7 Baculo_PEP_C PF04513.7 EPA06463.1 - 0.082 12.7 1.7 0.19 11.5 1.1 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3829 PF12889.2 EPA06463.1 - 0.086 12.0 0.9 0.12 11.5 0.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3829) Vps51 PF08700.6 EPA06463.1 - 0.13 12.0 0.4 0.13 12.0 0.3 2.3 3 1 0 3 3 3 0 Vps51/Vps67 NPV_P10 PF05531.7 EPA06463.1 - 0.14 12.3 3.1 2.9 8.2 0.3 2.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein F_actin_bind PF08919.5 EPA06463.1 - 0.15 11.8 1.7 13 5.5 0.0 2.3 2 1 0 2 2 2 0 F-actin binding FlaC_arch PF05377.6 EPA06463.1 - 0.46 10.4 4.3 9.5 6.2 1.2 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) ORF6C PF10552.4 EPA06463.1 - 0.49 10.1 2.7 1.3 8.7 0.3 2.0 1 1 1 2 2 2 0 ORF6C domain MCPsignal PF00015.16 EPA06463.1 - 1.1 8.7 5.3 0.97 8.9 0.8 2.0 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain tRNA_int_endo PF01974.12 EPA06465.1 - 2.1e-26 91.5 0.0 3.5e-26 90.8 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.9 EPA06465.1 - 9e-17 60.3 0.0 1.8e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain Ribosomal_L22e PF01776.12 EPA06465.1 - 0.063 13.2 0.5 0.093 12.7 0.4 1.2 1 0 0 1 1 1 0 Ribosomal L22e protein family Response_reg PF00072.19 EPA06466.1 - 2.8e-26 91.7 0.8 3.1e-26 91.5 0.6 1.0 1 0 0 1 1 1 1 Response regulator receiver domain Regulator_TrmB PF11495.3 EPA06467.1 - 0.00071 18.6 0.8 0.012 14.5 0.6 2.1 1 1 0 1 1 1 1 Archaeal transcriptional regulator TrmB PLDc_2 PF13091.1 EPA06467.1 - 0.012 15.3 0.9 0.18 11.5 0.6 2.4 1 1 0 1 1 1 0 PLD-like domain ESCRT-II PF05871.7 EPA06467.1 - 0.087 12.7 0.5 0.29 11.0 0.3 2.0 1 1 0 1 1 1 0 ESCRT-II complex subunit PhdYeFM_antitox PF02604.14 EPA06467.1 - 0.091 12.3 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system Abhydrolase_6 PF12697.2 EPA06468.1 - 3.2e-28 99.1 0.0 4.1e-28 98.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EPA06468.1 - 7e-22 77.7 0.0 1.1e-20 73.9 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EPA06468.1 - 4.3e-14 52.1 0.0 9.1e-14 51.0 0.0 1.4 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_1 PF00561.15 EPA06468.1 - 1.7e-10 40.8 0.1 2.4e-09 37.0 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EPA06468.1 - 0.00023 20.4 0.0 0.0032 16.7 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Ser_hydrolase PF06821.8 EPA06468.1 - 0.00096 18.7 0.0 0.0022 17.6 0.0 1.6 1 0 0 1 1 1 1 Serine hydrolase DUF1749 PF08538.5 EPA06468.1 - 0.00098 18.0 0.0 0.0027 16.6 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1749) FSH1 PF03959.8 EPA06468.1 - 0.0015 17.9 0.1 0.041 13.3 0.0 2.3 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Peptidase_S15 PF02129.13 EPA06468.1 - 0.0023 17.4 0.0 1.3 8.3 0.0 2.1 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Tannase PF07519.6 EPA06468.1 - 0.0028 16.4 0.0 0.026 13.2 0.0 1.9 1 1 1 2 2 2 1 Tannase and feruloyl esterase DUF2305 PF10230.4 EPA06468.1 - 0.0044 16.4 0.0 0.0087 15.5 0.0 1.6 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) DUF1057 PF06342.7 EPA06468.1 - 0.025 13.3 0.0 0.04 12.7 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) DLH PF01738.13 EPA06468.1 - 0.033 13.4 0.0 0.98 8.6 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Mago_nashi PF02792.9 EPA06468.1 - 0.048 13.3 0.0 2.3 7.8 0.0 2.3 2 0 0 2 2 2 0 Mago nashi protein LCAT PF02450.10 EPA06468.1 - 0.052 12.5 0.0 0.079 11.9 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF1350 PF07082.6 EPA06468.1 - 0.056 12.5 0.0 0.096 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1350) Tn7_Tnp_TnsA_C PF08721.6 EPA06469.1 - 0.28 11.2 1.3 2.2 8.3 0.1 2.0 1 1 1 2 2 2 0 TnsA endonuclease C terminal Methyltransf_31 PF13847.1 EPA06470.1 - 4.7e-19 68.4 0.1 6.8e-19 67.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA06470.1 - 2.8e-14 53.1 0.0 5.1e-14 52.3 0.0 1.4 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA06470.1 - 4.8e-14 52.6 0.0 7.2e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EPA06470.1 - 3.7e-10 40.0 0.0 1.8e-09 37.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA06470.1 - 1.7e-09 38.2 0.0 3.7e-09 37.1 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain CMAS PF02353.15 EPA06470.1 - 2.6e-08 33.2 0.0 3.8e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 EPA06470.1 - 4.4e-08 33.5 0.1 1.1e-07 32.1 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain PCMT PF01135.14 EPA06470.1 - 4.8e-07 29.5 0.0 8.3e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.9 EPA06470.1 - 9.8e-06 25.0 0.2 2.2e-05 23.9 0.0 1.6 2 1 0 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.13 EPA06470.1 - 3.9e-05 22.8 0.2 6.8e-05 22.0 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EPA06470.1 - 6.4e-05 22.9 0.0 8.6e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EPA06470.1 - 0.00018 21.5 0.2 0.00039 20.4 0.1 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase CheR PF01739.13 EPA06470.1 - 0.002 17.4 0.9 0.031 13.5 0.3 2.2 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain TehB PF03848.9 EPA06470.1 - 0.0026 16.9 0.1 0.0041 16.3 0.1 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB PrmA PF06325.8 EPA06470.1 - 0.0073 15.4 0.1 0.011 14.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) N6_N4_Mtase PF01555.13 EPA06470.1 - 0.0082 15.6 0.1 0.16 11.4 0.0 2.2 2 0 0 2 2 2 1 DNA methylase Methyltransf_32 PF13679.1 EPA06470.1 - 0.012 15.3 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 EPA06470.1 - 0.026 13.9 0.1 0.057 12.7 0.0 1.6 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW UPF0146 PF03686.8 EPA06470.1 - 0.027 14.2 0.0 0.046 13.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Methyltransf_9 PF08003.6 EPA06470.1 - 0.032 12.9 0.0 0.056 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) DREV PF05219.7 EPA06470.1 - 0.036 12.9 0.1 0.068 12.0 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase RrnaAD PF00398.15 EPA06470.1 - 0.054 12.5 0.0 0.083 11.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase FmrO PF07091.6 EPA06470.1 - 0.069 12.1 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) TrmB PF01978.14 EPA06471.1 - 0.02 14.5 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF1129 PF06570.6 EPA06472.1 - 0.00026 20.3 0.0 0.00026 20.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) Tetraspannin PF00335.15 EPA06472.1 - 0.0021 17.3 0.1 0.0026 17.0 0.1 1.1 1 0 0 1 1 1 1 Tetraspanin family CcmB PF03379.8 EPA06472.1 - 0.019 14.2 0.7 0.02 14.1 0.5 1.0 1 0 0 1 1 1 0 CcmB protein DUF4131 PF13567.1 EPA06472.1 - 0.026 13.9 0.6 0.028 13.8 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Neurensin PF14927.1 EPA06472.1 - 0.081 12.3 1.0 0.12 11.7 0.1 1.6 1 1 1 2 2 2 0 Neurensin PrgI PF12666.2 EPA06472.1 - 0.084 13.0 0.4 0.088 12.9 0.3 1.2 1 0 0 1 1 1 0 PrgI family protein GPI2 PF06432.6 EPA06472.1 - 0.086 12.1 0.1 0.093 12.0 0.1 1.0 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase Reticulon PF02453.12 EPA06472.1 - 0.1 12.2 1.0 0.11 12.0 0.7 1.1 1 0 0 1 1 1 0 Reticulon IncA PF04156.9 EPA06472.1 - 0.13 11.8 0.2 0.15 11.6 0.1 1.1 1 0 0 1 1 1 0 IncA protein DUF2456 PF10445.4 EPA06472.1 - 0.23 11.3 1.2 2.3 8.1 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2456) DUF3955 PF13127.1 EPA06472.1 - 7.2 6.2 10.0 0.53 9.8 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3955) UbiA PF01040.13 EPA06473.1 - 5.4e-28 97.9 16.5 7.2e-28 97.5 11.5 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF1673 PF07895.6 EPA06473.1 - 2 7.9 22.0 0.056 12.9 1.2 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1673) Cytochrom_B558a PF05038.8 EPA06473.1 - 2 8.0 6.7 0.16 11.5 0.8 2.0 2 0 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit NAD_binding_10 PF13460.1 EPA06474.1 - 1.4e-23 83.8 0.0 1.8e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EPA06474.1 - 2.3e-12 46.6 0.0 3.2e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.14 EPA06474.1 - 9.5e-12 44.1 0.1 1.4e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 EPA06474.1 - 1.2e-10 41.2 0.2 3e-09 36.6 0.1 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EPA06474.1 - 0.00031 19.7 0.2 0.0019 17.1 0.0 2.2 3 0 0 3 3 3 1 Male sterility protein adh_short PF00106.20 EPA06474.1 - 0.0013 18.7 0.0 0.0031 17.4 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.12 EPA06474.1 - 0.0031 16.4 0.0 0.0066 15.3 0.0 1.5 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 EPA06474.1 - 0.006 15.5 1.3 0.091 11.6 0.9 2.2 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Cas_Csm6 PF09659.5 EPA06474.1 - 0.013 14.1 0.0 0.019 13.5 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csm6) KR PF08659.5 EPA06474.1 - 0.019 14.6 0.2 0.2 11.2 0.1 2.2 1 1 0 1 1 1 0 KR domain DapB_N PF01113.15 EPA06474.1 - 0.08 12.8 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ATPase_gene1 PF09527.5 EPA06476.1 - 0.059 13.1 0.9 0.07 12.9 0.6 1.2 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit (ATPase_gene1) Diphthamide_syn PF01866.12 EPA06477.1 - 1.4e-42 146.0 0.0 1.7e-42 145.7 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein TPR_11 PF13414.1 EPA06478.1 - 6.5e-11 41.7 0.2 5.5e-05 22.7 0.0 2.4 1 1 2 3 3 3 3 TPR repeat TPR_1 PF00515.23 EPA06478.1 - 1.9e-10 39.8 2.2 8.9e-05 21.9 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 EPA06478.1 - 7.6e-08 31.7 0.1 0.049 13.5 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 EPA06478.1 - 9.9e-08 32.4 0.0 0.0072 16.9 0.0 2.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 EPA06478.1 - 1.8e-06 28.2 0.0 5.2e-05 23.5 0.0 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 EPA06478.1 - 0.00036 20.1 0.8 0.47 10.3 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat Apc3 PF12895.2 EPA06478.1 - 0.00038 20.5 1.4 0.012 15.7 0.4 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.1 EPA06478.1 - 0.00068 19.4 0.2 0.058 13.2 0.0 3.0 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.1 EPA06478.1 - 0.0027 17.6 0.0 2.4 8.1 0.0 2.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.1 EPA06478.1 - 0.0029 17.9 0.0 0.86 10.2 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 EPA06478.1 - 0.0059 17.1 0.0 22 6.0 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 EPA06478.1 - 0.065 13.4 0.2 61 4.1 0.0 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat PPTA PF01239.17 EPA06478.1 - 0.13 11.7 1.8 0.17 11.3 0.1 2.1 3 0 0 3 3 3 0 Protein prenyltransferase alpha subunit repeat Diphthamide_syn PF01866.12 EPA06479.1 - 4.9e-43 147.5 0.0 5.7e-43 147.2 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein TPR_1 PF00515.23 EPA06480.1 - 2.1e-10 39.7 3.1 8.8e-05 21.9 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 EPA06480.1 - 4.5e-09 35.8 0.3 4.2e-05 23.1 0.0 2.2 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 EPA06480.1 - 2.2e-08 33.3 0.4 0.026 14.4 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 EPA06480.1 - 2.8e-08 33.9 0.0 4.2e-05 23.7 0.0 2.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 EPA06480.1 - 3.4e-08 33.9 0.0 0.0019 18.7 0.0 2.5 1 1 2 3 3 3 3 Tetratricopeptide repeat Apc3 PF12895.2 EPA06480.1 - 8.1e-05 22.6 4.1 0.0064 16.5 0.1 2.0 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.1 EPA06480.1 - 0.00018 21.3 0.2 0.059 13.2 0.0 3.1 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.1 EPA06480.1 - 0.00087 19.7 0.0 26 5.8 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 EPA06480.1 - 0.0018 17.9 3.6 0.36 10.7 0.1 4.1 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 EPA06480.1 - 0.0024 18.2 0.1 1.3 9.6 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 EPA06480.1 - 0.0047 16.8 0.0 2.2 8.3 0.0 2.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 EPA06480.1 - 0.13 12.5 0.4 1.1e+02 3.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PPTA PF01239.17 EPA06480.1 - 0.16 11.3 1.1 0.35 10.2 0.1 2.1 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat MscL PF01741.13 EPA06482.1 - 4.2e-19 68.9 7.5 4.5e-19 68.8 5.2 1.0 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL Reticulon PF02453.12 EPA06482.1 - 0.022 14.3 0.3 0.029 13.9 0.2 1.2 1 0 0 1 1 1 0 Reticulon FtsX PF02687.16 EPA06482.1 - 0.067 12.9 5.5 0.094 12.4 3.8 1.1 1 0 0 1 1 1 0 FtsX-like permease family Colicin_V PF02674.11 EPA06482.1 - 0.2 11.4 8.8 0.41 10.5 6.1 1.5 1 1 0 1 1 1 0 Colicin V production protein Glycoprotein_B PF00606.13 EPA06482.1 - 0.73 7.7 3.8 0.19 9.7 0.4 1.5 2 0 0 2 2 2 0 Herpesvirus Glycoprotein B TM_helix PF05552.7 EPA06482.1 - 0.88 9.2 6.3 2.9 7.6 0.4 2.3 2 0 0 2 2 2 0 Conserved TM helix Apq12 PF12716.2 EPA06482.1 - 4.2 7.1 10.4 0.24 11.1 2.9 1.9 2 0 0 2 2 2 0 Nuclear pore assembly and biogenesis Polyketide_cyc2 PF10604.4 EPA06484.1 - 3.6e-13 49.8 0.0 4.1e-13 49.6 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 EPA06484.1 - 0.023 14.6 0.0 0.027 14.4 0.0 1.1 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport APG6 PF04111.7 EPA06485.1 - 8.2e-06 25.0 27.6 0.0034 16.4 10.6 2.2 2 0 0 2 2 2 2 Autophagy protein Apg6 AAA_13 PF13166.1 EPA06485.1 - 3.8e-05 22.3 41.3 7.2e-05 21.4 12.4 2.2 1 1 1 2 2 2 2 AAA domain Baculo_PEP_C PF04513.7 EPA06485.1 - 0.00079 19.2 1.7 0.00079 19.2 1.2 5.1 1 1 4 5 5 5 2 Baculovirus polyhedron envelope protein, PEP, C terminus Snapin_Pallidin PF14712.1 EPA06485.1 - 0.00095 19.4 5.0 0.00095 19.4 3.4 4.5 2 1 1 4 4 4 1 Snapin/Pallidin GAS PF13851.1 EPA06485.1 - 0.0036 16.5 7.2 0.0036 16.5 5.0 3.2 2 1 0 2 2 2 1 Growth-arrest specific micro-tubule binding RBD-FIP PF09457.5 EPA06485.1 - 0.0048 16.6 5.1 0.0072 16.0 1.6 2.8 2 0 0 2 2 2 1 FIP domain CENP-F_leu_zip PF10473.4 EPA06485.1 - 0.0079 16.0 5.5 0.0079 16.0 3.8 3.6 3 2 1 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1687 PF07955.6 EPA06485.1 - 0.015 15.2 7.8 0.017 15.1 1.9 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1687) BLOC1_2 PF10046.4 EPA06485.1 - 0.049 13.7 36.4 0.027 14.6 4.5 5.0 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 IncA PF04156.9 EPA06485.1 - 0.058 12.9 35.5 0.39 10.3 12.0 3.4 2 1 1 3 3 3 0 IncA protein Vac_Fusion PF02346.11 EPA06485.1 - 0.091 12.1 6.9 2.5 7.6 0.3 3.8 3 2 0 3 3 3 0 Chordopoxvirus fusion protein DUF4349 PF14257.1 EPA06485.1 - 0.16 11.1 4.7 1.3 8.2 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) CSTF2_hinge PF14327.1 EPA06485.1 - 0.28 11.2 9.1 0.11 12.6 0.9 3.3 2 1 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 Mod_r PF07200.8 EPA06485.1 - 0.31 10.9 25.9 0.08 12.8 7.2 3.4 3 1 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF4351 PF14261.1 EPA06485.1 - 0.78 9.6 11.2 8.3 6.3 0.2 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4351) Reo_sigmaC PF04582.7 EPA06485.1 - 0.87 8.6 23.5 0.13 11.4 2.1 3.3 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Spc7 PF08317.6 EPA06485.1 - 1.2 7.7 39.8 0.033 12.8 9.6 3.1 1 1 0 2 2 2 0 Spc7 kinetochore protein Cep57_CLD_2 PF14197.1 EPA06485.1 - 1.3 9.0 8.7 0.42 10.5 0.2 2.9 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Lzipper-MIP1 PF14389.1 EPA06485.1 - 1.4 9.1 14.5 0.051 13.6 2.9 3.5 3 1 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 DUF342 PF03961.8 EPA06485.1 - 1.4 7.2 35.1 0.086 11.2 8.0 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF342) Tropomyosin_1 PF12718.2 EPA06485.1 - 1.8 8.3 26.5 0.79 9.5 6.7 3.4 2 1 1 3 3 3 0 Tropomyosin like RP-C_C PF11800.3 EPA06485.1 - 2.1 7.9 17.2 0.57 9.8 4.3 3.0 2 2 0 2 2 2 0 Replication protein C C-terminal region MCPsignal PF00015.16 EPA06485.1 - 2.5 7.6 24.4 0.3 10.6 1.6 3.2 2 1 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain NPV_P10 PF05531.7 EPA06485.1 - 2.5 8.3 39.3 0.11 12.7 1.3 6.6 3 3 3 6 6 6 0 Nucleopolyhedrovirus P10 protein DUF4140 PF13600.1 EPA06485.1 - 2.7 8.4 13.4 3.4 8.1 0.2 4.1 2 2 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) AKNA PF12443.3 EPA06485.1 - 4 7.5 18.5 3.1 7.8 3.8 3.3 2 1 1 3 3 3 0 AT-hook-containing transcription factor DUF948 PF06103.6 EPA06485.1 - 5.9 6.8 37.3 1.2 9.0 1.4 6.0 3 2 3 6 6 6 0 Bacterial protein of unknown function (DUF948) Hrs_helical PF12210.3 EPA06485.1 - 8.5 6.7 13.1 15 5.9 0.4 4.0 2 2 1 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate AsnC_trans_reg PF01037.16 EPA06486.1 - 6.6e-10 38.5 0.1 7.9e-10 38.3 0.1 1.0 1 0 0 1 1 1 1 AsnC family LAGLIDADG_WhiA PF14527.1 EPA06486.1 - 0.12 12.2 0.2 0.29 11.0 0.0 1.7 1 1 0 1 1 1 0 WhiA LAGLIDADG-like domain ITI_HC_C PF06668.7 EPA06487.1 - 0.13 11.6 0.4 0.41 10.0 0.1 1.8 2 0 0 2 2 2 0 Inter-alpha-trypsin inhibitor heavy chain C-terminus Cellulase-like PF12876.2 EPA06489.1 - 0.011 16.1 0.0 0.011 16.1 0.0 1.0 1 0 0 1 1 1 0 Sugar-binding cellulase-like DUF2663 PF10864.3 EPA06489.1 - 0.067 13.4 0.0 0.083 13.1 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2663) SbcD_C PF12320.3 EPA06489.1 - 0.11 12.5 0.4 0.12 12.4 0.3 1.2 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain PAP_central PF04928.12 EPA06489.1 - 0.18 10.5 0.5 0.18 10.5 0.4 1.0 1 0 0 1 1 1 0 Poly(A) polymerase central domain UBN2 PF14223.1 EPA06490.1 - 0.08 12.7 0.4 0.085 12.6 0.3 1.2 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Phi-29_GP3 PF05435.6 EPA06490.1 - 0.088 12.0 0.1 0.092 11.9 0.1 1.1 1 0 0 1 1 1 0 Phi-29 DNA terminal protein GP3 Guanylate_cyc PF00211.15 EPA06491.1 - 0.0026 17.1 0.1 0.004 16.5 0.1 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Prok-JAB PF14464.1 EPA06493.1 - 2.1e-13 49.7 0.0 2.6e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain JAB PF01398.16 EPA06493.1 - 0.0026 17.4 0.1 0.039 13.6 0.0 2.0 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease AHSA1 PF08327.6 EPA06494.1 - 6.5e-21 74.7 0.3 7.4e-21 74.5 0.2 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.4 EPA06494.1 - 0.0023 18.0 0.0 0.003 17.7 0.0 1.3 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport S_locus_glycop PF00954.15 EPA06494.1 - 0.022 15.0 0.2 0.036 14.3 0.2 1.3 1 0 0 1 1 1 0 S-locus glycoprotein family Asp PF00026.18 EPA06494.1 - 0.027 13.7 0.2 0.03 13.5 0.1 1.1 1 0 0 1 1 1 0 Eukaryotic aspartyl protease COXG PF06240.8 EPA06494.1 - 0.045 13.4 0.0 0.09 12.4 0.0 1.5 2 0 0 2 2 2 0 Carbon monoxide dehydrogenase subunit G (CoxG) DUF202 PF02656.10 EPA06495.1 - 0.031 14.4 0.0 0.044 14.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) 7TMR-DISM_7TM PF07695.6 EPA06495.1 - 0.064 12.9 1.8 4.3 6.9 0.1 1.9 2 0 0 2 2 2 0 7TM diverse intracellular signalling JTB PF05439.7 EPA06495.1 - 0.069 12.9 0.0 0.096 12.4 0.0 1.3 1 0 0 1 1 1 0 Jumping translocation breakpoint protein (JTB) YfkB PF08756.5 EPA06495.1 - 0.089 12.3 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 YfkB-like domain DUF3671 PF12420.3 EPA06495.1 - 0.09 12.7 1.6 0.12 12.3 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF3185 PF11381.3 EPA06495.1 - 0.87 9.3 6.7 2.4 7.9 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) DUF4097 PF13349.1 EPA06495.1 - 0.97 8.9 3.2 3.2 7.2 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4097) DUF1206 PF06724.6 EPA06495.1 - 1.6 8.5 8.3 0.22 11.3 0.6 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1206) Tetraspannin PF00335.15 EPA06495.1 - 1.6 7.9 7.1 5.7 6.1 0.3 2.0 1 1 1 2 2 2 0 Tetraspanin family Mrr_N PF14338.1 EPA06498.1 - 0.032 14.3 0.3 0.039 14.0 0.2 1.3 1 1 0 1 1 1 0 Mrr N-terminal domain GEMIN8 PF15348.1 EPA06502.1 - 0.061 13.3 2.1 0.06 13.3 1.5 1.0 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 APC_CDC26 PF10471.4 EPA06502.1 - 0.22 12.2 3.8 0.24 12.1 2.6 1.1 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 ETRAMP PF09716.5 EPA06503.1 - 0.1 12.5 0.5 0.11 12.4 0.3 1.1 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) 7TM_GPCR_Srb PF02175.11 EPA06503.1 - 0.12 11.9 0.3 0.11 12.0 0.2 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srb Malic_M PF03949.10 EPA06504.1 - 1.1e-56 192.2 2.1 1.4e-56 191.8 1.5 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 EPA06504.1 - 7.3e-26 90.8 7.2 2.5e-23 82.5 0.3 3.6 2 2 0 2 2 2 1 Malic enzyme, N-terminal domain AdoHcyase_NAD PF00670.16 EPA06504.1 - 0.00013 21.8 2.3 0.0016 18.3 0.8 2.9 2 1 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ELFV_dehydrog PF00208.16 EPA06504.1 - 0.00055 19.5 1.6 0.0013 18.3 0.4 2.0 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Shikimate_DH PF01488.15 EPA06504.1 - 0.0014 18.7 0.9 0.0057 16.7 0.6 2.0 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.14 EPA06504.1 - 0.0078 15.3 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 EPA06504.1 - 0.0099 15.7 0.2 0.019 14.8 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.16 EPA06504.1 - 0.01 15.6 0.8 0.033 14.0 0.5 1.9 1 0 0 1 1 1 0 ThiF family 3HCDH_N PF02737.13 EPA06504.1 - 0.046 13.3 0.1 0.088 12.4 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.14 EPA06504.1 - 0.31 10.0 2.9 3 6.8 0.2 3.5 4 1 1 5 5 5 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Sugarporin_N PF11471.3 EPA06506.1 - 0.045 13.3 3.2 0.078 12.6 2.2 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension DUF2680 PF10925.3 EPA06506.1 - 0.077 12.8 1.1 1.7 8.5 2.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) phage_tail_N PF08400.5 EPA06506.1 - 0.13 11.9 0.2 0.26 10.9 0.1 1.5 1 0 0 1 1 1 0 Prophage tail fibre N-terminal Prefoldin_2 PF01920.15 EPA06506.1 - 0.31 10.8 8.0 1.3 8.8 3.4 2.3 2 0 0 2 2 2 0 Prefoldin subunit SlyX PF04102.7 EPA06506.1 - 0.31 11.4 4.4 0.42 11.0 0.5 2.2 2 0 0 2 2 2 0 SlyX Seryl_tRNA_N PF02403.17 EPA06506.1 - 1.3 9.0 7.1 0.66 10.0 1.8 2.1 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain tRNA-synt_1 PF00133.17 EPA06508.1 - 8.5e-16 57.0 0.2 4.8e-15 54.5 0.2 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 EPA06508.1 - 1.2e-11 43.8 0.0 2.4e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 EPA06508.1 - 7.5e-07 28.5 0.0 1.1e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Calci_bind_CcbP PF11535.3 EPA06513.1 - 0.11 12.7 0.3 8.2 6.7 0.0 2.2 2 0 0 2 2 2 0 Calcium binding DUF87 PF01935.12 EPA06514.1 - 1.7e-17 64.0 0.8 1.7e-16 60.7 0.2 2.4 1 1 1 2 2 2 1 Domain of unknown function DUF87 AAA_10 PF12846.2 EPA06514.1 - 2.1e-13 50.3 0.9 1e-12 48.1 0.6 2.2 1 1 0 1 1 1 1 AAA-like domain FtsK_SpoIIIE PF01580.13 EPA06514.1 - 1.2e-07 31.4 0.0 0.0012 18.4 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.4 EPA06514.1 - 0.0051 15.4 0.0 0.062 11.9 0.0 2.2 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain FliH PF02108.11 EPA06514.1 - 0.019 14.8 0.4 0.051 13.4 0.1 1.8 2 0 0 2 2 2 0 Flagellar assembly protein FliH AAA PF00004.24 EPA06514.1 - 0.046 13.9 1.4 4.5 7.4 0.0 3.5 2 2 2 4 4 4 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EPA06514.1 - 0.069 13.1 0.0 15 5.5 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.18 EPA06514.1 - 0.07 13.0 0.2 0.41 10.6 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase SH3_9 PF14604.1 EPA06515.1 - 0.1 12.2 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain DUF87 PF01935.12 EPA06515.1 - 0.13 12.0 1.3 0.35 10.6 0.5 2.0 2 1 0 2 2 2 0 Domain of unknown function DUF87 QueC PF06508.8 EPA06517.1 - 4.7e-66 222.0 0.0 5.3e-66 221.8 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC ThiI PF02568.9 EPA06517.1 - 0.00076 18.9 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) ATP_bind_4 PF01902.12 EPA06517.1 - 0.0015 17.9 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 ATP-binding region Asn_synthase PF00733.16 EPA06517.1 - 0.0028 17.1 0.0 0.0043 16.5 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase ATP_bind_3 PF01171.15 EPA06517.1 - 0.0053 16.2 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 PP-loop family NAD_synthase PF02540.12 EPA06517.1 - 0.0095 14.8 0.0 0.12 11.2 0.0 2.0 2 0 0 2 2 2 1 NAD synthase tRNA_Me_trans PF03054.11 EPA06517.1 - 0.052 12.0 0.0 0.079 11.4 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase Glutaredoxin PF00462.19 EPA06517.1 - 0.15 12.0 0.6 0.29 11.1 0.0 1.8 2 0 0 2 2 2 0 Glutaredoxin DUF2419 PF10343.4 EPA06518.1 - 9.3e-11 41.5 0.7 3.6e-09 36.3 0.5 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF2419) EF-hand_1 PF00036.27 EPA06518.1 - 0.048 12.9 0.5 0.13 11.6 0.3 1.8 1 0 0 1 1 1 0 EF hand DUF2481 PF10654.4 EPA06518.1 - 0.11 12.1 0.7 4.8 6.8 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2481) EF-hand_6 PF13405.1 EPA06518.1 - 2.7 8.1 4.2 0.95 9.5 0.3 2.2 2 0 0 2 2 2 0 EF-hand domain KSHV_K1 PF11049.3 EPA06519.1 - 0.073 13.0 0.0 0.092 12.7 0.0 1.2 1 0 0 1 1 1 0 Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus SAPS PF04499.10 EPA06520.1 - 0.043 12.4 0.0 0.044 12.4 0.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CTD_bind PF04818.8 EPA06520.1 - 0.12 12.6 0.5 0.15 12.3 0.3 1.1 1 0 0 1 1 1 0 RNA polymerase II-binding domain. Cor1 PF04803.7 EPA06520.1 - 0.13 12.0 1.7 0.15 11.8 1.2 1.0 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region Vac14_Fab1_bd PF12755.2 EPA06520.1 - 0.14 12.6 0.1 0.15 12.4 0.1 1.1 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region Transp_Tc5_C PF04236.10 EPA06521.1 - 0.016 15.4 9.3 0.024 14.8 6.4 1.2 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain DUF4187 PF13821.1 EPA06521.1 - 0.024 14.2 1.4 0.059 12.9 1.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4187) FYVE_2 PF02318.11 EPA06521.1 - 0.027 14.3 7.1 0.034 14.0 4.9 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger RHH_3 PF12651.2 EPA06521.1 - 0.029 14.0 1.1 0.06 13.0 0.7 1.5 1 1 0 1 1 1 0 Ribbon-helix-helix domain DUF104 PF01954.11 EPA06521.1 - 0.072 13.1 0.8 0.13 12.2 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF104 zf-CSL PF05207.8 EPA06521.1 - 2.4 7.7 10.7 4.7 6.7 7.4 1.5 1 0 0 1 1 1 0 CSL zinc finger PTPS PF01242.14 EPA06522.1 - 2.5e-27 95.0 0.1 2.7e-27 94.8 0.0 1.0 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase IMPDH PF00478.20 EPA06523.1 - 1.9e-76 257.2 8.7 2.1e-76 257.0 6.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.10 EPA06523.1 - 2.7e-06 26.7 2.6 3.7e-06 26.3 1.8 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.13 EPA06523.1 - 4.1e-06 25.8 4.7 4.5e-06 25.7 2.6 1.5 2 0 0 2 2 2 1 FMN-dependent dehydrogenase DHO_dh PF01180.16 EPA06523.1 - 0.00028 19.9 1.3 0.00028 19.9 0.9 1.8 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase His_biosynth PF00977.16 EPA06523.1 - 0.0013 18.0 0.6 0.0036 16.6 0.1 2.0 1 1 1 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.9 EPA06523.1 - 0.0092 15.0 1.1 0.015 14.3 0.3 1.5 1 1 0 1 1 1 1 Thiazole biosynthesis protein ThiG ADH_zinc_N PF00107.21 EPA06523.1 - 0.026 14.0 0.4 1.1 8.7 0.1 2.3 1 1 1 2 2 2 0 Zinc-binding dehydrogenase NanE PF04131.9 EPA06523.1 - 0.051 12.5 2.5 0.44 9.4 0.1 2.1 1 1 1 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase DeoC PF01791.4 EPA06523.1 - 0.057 12.6 1.3 0.084 12.1 0.9 1.3 1 0 0 1 1 1 0 DeoC/LacD family aldolase Glu_synthase PF01645.12 EPA06523.1 - 0.067 12.0 3.1 0.097 11.5 2.2 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase Fil_haemagg PF05594.9 EPA06525.1 - 0.014 15.7 6.6 0.014 15.7 4.6 3.1 1 1 1 2 2 2 0 Haemagluttinin repeat STT3 PF02516.9 EPA06526.1 - 0.0029 16.6 2.1 0.0033 16.4 1.4 1.0 1 0 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit DUF4624 PF15417.1 EPA06527.1 - 0.026 14.1 0.2 0.66 9.5 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4624) Diphthamide_syn PF01866.12 EPA06528.1 - 8.1e-05 22.0 0.0 8.1e-05 22.0 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Diphthamide_syn PF01866.12 EPA06529.1 - 8.7e-11 41.6 0.0 9.7e-11 41.4 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein TFIIE_alpha PF02002.12 EPA06530.1 - 2.7e-18 65.4 0.8 4.6e-18 64.6 0.6 1.4 1 0 0 1 1 1 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.7 EPA06530.1 - 0.0074 15.5 0.7 0.016 14.5 0.5 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding DUF3834 PF12916.2 EPA06530.1 - 0.028 13.4 0.2 0.038 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) TrmB PF01978.14 EPA06530.1 - 0.034 13.8 0.0 0.074 12.7 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Sigma70_r3 PF04539.11 EPA06530.1 - 0.13 12.1 0.7 0.32 10.9 0.0 1.9 2 0 0 2 2 2 0 Sigma-70 region 3 Zn_ribbon_recom PF13408.1 EPA06530.1 - 0.14 12.4 0.1 0.14 12.4 0.1 2.4 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain DNA_ligase_ZBD PF03119.11 EPA06530.1 - 0.17 11.6 0.1 0.17 11.6 0.1 1.6 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Elf1 PF05129.8 EPA06530.1 - 0.52 10.0 3.7 1.2 8.9 2.6 1.7 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-C4_Topoisom PF01396.14 EPA06530.1 - 0.91 9.0 3.7 0.71 9.4 0.2 2.3 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Methyltransf_11 PF08241.7 EPA06531.1 - 3.1e-07 30.7 0.0 4.6e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA06531.1 - 1.9e-06 27.5 0.2 2.2e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.6 EPA06531.1 - 4.5e-06 26.2 0.0 5.1e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_12 PF08242.7 EPA06531.1 - 5.4e-06 26.8 0.0 1.3e-05 25.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA06531.1 - 0.0013 19.3 0.0 0.0018 18.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EPA06531.1 - 0.0019 17.3 0.1 0.0024 17.0 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 EPA06531.1 - 0.0029 17.3 0.0 0.0037 17.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EPA06531.1 - 0.049 12.7 0.0 0.057 12.5 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family N6_N4_Mtase PF01555.13 EPA06531.1 - 0.052 13.0 0.1 0.06 12.8 0.1 1.1 1 0 0 1 1 1 0 DNA methylase Methyltransf_25 PF13649.1 EPA06531.1 - 0.087 13.1 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Pox_polyA_pol_N PF12630.2 EPA06531.1 - 0.52 10.4 3.1 0.82 9.7 2.1 1.3 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase N-terminal domain Trm56 PF01994.11 EPA06532.1 - 3.8e-50 168.6 0.3 6e-50 168.0 0.2 1.3 1 0 0 1 1 1 1 tRNA ribose 2'-O-methyltransferase, aTrm56 SPOUT_MTase_2 PF14419.1 EPA06532.1 - 0.0026 16.9 0.0 0.0035 16.5 0.0 1.3 1 0 0 1 1 1 1 AF2226-like SPOUT RNA Methylase fused to THUMP HMG_box_2 PF09011.5 EPA06532.1 - 0.045 14.1 0.3 0.092 13.1 0.2 1.4 1 0 0 1 1 1 0 HMG-box domain DXP_reductoisom PF02670.11 EPA06532.1 - 0.068 13.7 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase DUF531 PF04407.7 EPA06532.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF531) MMR_HSR1 PF01926.18 EPA06533.1 - 8.7e-18 64.3 0.4 4.4e-17 62.1 0.1 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP-bdg_N PF13167.1 EPA06533.1 - 1.8e-10 40.7 0.2 8.5e-10 38.6 0.0 2.3 2 0 0 2 2 2 1 GTP-binding GTPase N-terminal FeoB_N PF02421.13 EPA06533.1 - 2.3e-09 36.7 1.0 2.9e-09 36.4 0.2 1.5 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 EPA06533.1 - 3.1e-06 26.7 3.8 0.00028 20.3 2.6 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 EPA06533.1 - 0.0033 17.9 0.7 0.012 16.1 0.2 2.3 2 1 0 2 2 1 1 Miro-like protein SRPRB PF09439.5 EPA06533.1 - 0.0033 16.6 2.0 0.0067 15.6 1.4 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF258 PF03193.11 EPA06533.1 - 0.0061 15.7 0.5 0.016 14.4 0.2 1.8 1 1 0 1 1 1 1 Protein of unknown function, DUF258 T2SE PF00437.15 EPA06533.1 - 0.0089 14.9 0.1 0.021 13.7 0.1 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein Arf PF00025.16 EPA06533.1 - 0.0096 15.1 4.8 0.051 12.8 2.8 2.4 1 1 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.4 EPA06533.1 - 0.018 14.4 6.7 0.22 10.9 3.5 3.0 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 EPA06533.1 - 0.02 14.6 0.3 0.046 13.4 0.1 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 EPA06533.1 - 0.02 15.2 0.2 0.063 13.5 0.1 2.0 1 1 0 1 1 1 0 ABC transporter Dynamin_N PF00350.18 EPA06533.1 - 0.024 14.4 1.6 0.81 9.4 0.3 3.0 2 2 1 3 3 3 0 Dynamin family cobW PF02492.14 EPA06533.1 - 0.048 13.1 5.2 1.6 8.1 0.2 2.4 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.1 EPA06533.1 - 0.44 10.4 5.0 4.4 7.2 1.7 3.0 2 1 0 2 2 2 0 AAA domain DUF1192 PF06698.6 EPA06533.1 - 0.89 9.4 8.1 0.63 9.8 0.2 3.0 3 0 0 3 3 2 0 Protein of unknown function (DUF1192) NTPase_1 PF03266.10 EPA06533.1 - 8 6.1 10.0 4.7 6.8 0.2 4.1 3 2 2 5 5 5 0 NTPase Phage_integrase PF00589.17 EPA06534.1 - 5.8e-06 26.0 0.7 0.00015 21.4 0.5 2.5 1 1 0 1 1 1 1 Phage integrase family DUF4065 PF13274.1 EPA06535.1 - 0.019 15.6 0.5 0.024 15.3 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4065) DUF2188 PF09954.4 EPA06535.1 - 0.022 14.6 1.9 0.03 14.2 0.5 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) DUF3936 PF13072.1 EPA06535.1 - 1.2 8.6 4.6 11 5.5 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3936) GatB_N PF02934.10 EPA06537.1 - 1.1e-75 254.2 0.1 1.2e-75 254.0 0.0 1.0 1 0 0 1 1 1 1 GatB/GatE catalytic domain tRNA-synt_2 PF00152.15 EPA06539.1 - 2.4e-25 89.0 0.1 2.6e-25 88.9 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 EPA06539.1 - 0.0044 16.2 0.0 0.0044 16.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) IF2_N PF04760.10 EPA06541.1 - 0.028 14.0 0.1 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region DUF1246 PF06849.7 EPA06542.1 - 3.6e-22 78.4 0.0 3.8e-22 78.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1246) Saccharop_dh_N PF04455.7 EPA06543.1 - 4.1e-37 126.4 0.4 8.9e-37 125.3 0.3 1.6 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region DUF295 PF03478.13 EPA06543.1 - 0.14 11.5 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF295) Pyr_redox PF00070.22 EPA06545.1 - 0.025 15.0 0.1 0.029 14.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ProRS-C_2 PF09181.5 EPA06545.1 - 0.1 12.5 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Prolyl-tRNA synthetase, C-terminal DUF1297 PF06973.7 EPA06546.1 - 3.3e-74 248.2 0.1 4.1e-74 247.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) DUF1246 PF06849.7 EPA06546.1 - 1.8e-15 56.8 0.0 3.7e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1246) ATP-grasp_4 PF13535.1 EPA06546.1 - 0.0076 16.0 0.1 0.061 13.0 0.0 2.1 1 1 0 1 1 1 1 ATP-grasp domain Arc_PepC_II PF06847.6 EPA06547.1 - 1.3e-09 38.3 0.1 1.3e-09 38.3 0.0 2.3 2 0 0 2 2 2 1 Archaeal Peptidase A24 C-terminus Type II Peptidase_A24 PF01478.13 EPA06547.1 - 7.9e-07 29.2 9.4 1.5e-06 28.3 6.5 1.5 1 0 0 1 1 1 1 Type IV leader peptidase family HTH_20 PF12840.2 EPA06548.1 - 2e-05 24.2 0.0 3e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.14 EPA06548.1 - 3.8e-05 23.3 0.1 6.2e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.7 EPA06548.1 - 8e-05 22.2 0.2 0.00014 21.4 0.1 1.5 1 0 0 1 1 1 1 HTH domain HTH_7 PF02796.10 EPA06548.1 - 0.00066 19.4 0.1 0.0014 18.4 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase Mga PF05043.8 EPA06548.1 - 0.00081 19.6 1.5 0.0019 18.4 0.3 1.8 1 1 1 2 2 2 1 Mga helix-turn-helix domain HTH_5 PF01022.15 EPA06548.1 - 0.0012 18.4 0.1 0.0021 17.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_IclR PF09339.5 EPA06548.1 - 0.0017 17.9 0.0 0.0024 17.4 0.0 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_23 PF13384.1 EPA06548.1 - 0.0025 17.4 0.0 0.0042 16.6 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain FUR PF01475.14 EPA06548.1 - 0.0038 17.1 0.2 0.0048 16.8 0.1 1.4 1 1 0 1 1 1 1 Ferric uptake regulator family DUF4423 PF14394.1 EPA06548.1 - 0.0048 16.4 0.1 0.0055 16.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) HTH_40 PF14493.1 EPA06548.1 - 0.0048 17.0 0.6 0.0066 16.6 0.4 1.3 1 1 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.2 EPA06548.1 - 0.0093 15.6 0.0 0.017 14.7 0.0 1.4 1 1 0 1 1 1 1 MarR family DUF1492 PF07374.6 EPA06548.1 - 0.0094 16.0 0.2 0.014 15.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1492) Fe_dep_repress PF01325.14 EPA06548.1 - 0.015 15.2 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Sigma70_r4_2 PF08281.7 EPA06548.1 - 0.022 14.2 0.1 0.04 13.3 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_22 PF13309.1 EPA06548.1 - 0.028 14.1 0.0 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 HTH domain HTH_24 PF13412.1 EPA06548.1 - 0.028 13.7 0.0 0.056 12.8 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_28 PF13518.1 EPA06548.1 - 0.03 14.3 0.0 0.05 13.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_36 PF13730.1 EPA06548.1 - 0.034 14.2 0.1 0.052 13.6 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain GerE PF00196.14 EPA06548.1 - 0.059 12.6 0.1 0.11 11.7 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family DUF2250 PF10007.4 EPA06548.1 - 0.088 12.7 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) HTH_45 PF14947.1 EPA06548.1 - 0.099 12.4 0.3 0.24 11.2 0.1 1.7 1 1 1 2 2 2 0 Winged helix-turn-helix HTH_34 PF13601.1 EPA06548.1 - 0.1 12.6 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain MarR PF01047.17 EPA06548.1 - 0.1 12.3 0.1 0.19 11.4 0.1 1.5 1 0 0 1 1 1 0 MarR family KaiC PF06745.8 EPA06549.1 - 7.3e-60 201.8 0.2 9e-60 201.6 0.2 1.0 1 0 0 1 1 1 1 KaiC GvpD PF07088.6 EPA06549.1 - 1.6e-13 49.8 0.0 2.1e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 GvpD gas vesicle protein AAA_25 PF13481.1 EPA06549.1 - 7.7e-07 28.7 0.0 2.1e-06 27.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.10 EPA06549.1 - 6.8e-06 25.1 0.0 1.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.1 EPA06549.1 - 0.00025 21.1 0.1 0.0028 17.8 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EPA06549.1 - 0.00064 20.0 0.1 0.0015 18.8 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EPA06549.1 - 0.001 18.9 0.0 0.0031 17.3 0.0 2.0 1 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EPA06549.1 - 0.0014 18.3 0.0 0.0028 17.3 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain RecA PF00154.16 EPA06549.1 - 0.0016 17.5 0.0 0.0027 16.8 0.0 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_17 PF13207.1 EPA06549.1 - 0.0045 17.7 1.3 0.0099 16.6 0.9 1.8 1 1 0 1 1 1 1 AAA domain T2SE PF00437.15 EPA06549.1 - 0.0065 15.4 0.0 0.013 14.4 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein PPV_E1_C PF00519.12 EPA06549.1 - 0.0075 14.9 0.0 1.3 7.5 0.0 2.2 2 0 0 2 2 2 1 Papillomavirus helicase AAA_24 PF13479.1 EPA06549.1 - 0.0084 15.7 0.9 0.036 13.6 0.6 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EPA06549.1 - 0.013 15.4 0.0 0.022 14.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 EPA06549.1 - 0.013 14.9 0.0 0.069 12.5 0.0 2.1 3 0 0 3 3 3 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.13 EPA06549.1 - 0.013 14.9 0.0 0.028 13.8 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Arch_ATPase PF01637.13 EPA06549.1 - 0.016 14.9 0.0 0.028 14.1 0.0 1.4 1 1 0 1 1 1 0 Archaeal ATPase NACHT PF05729.7 EPA06549.1 - 0.018 14.7 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.1 EPA06549.1 - 0.022 14.7 0.0 0.03 14.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_31 PF13614.1 EPA06549.1 - 0.031 14.2 0.0 0.054 13.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain DAP3 PF10236.4 EPA06549.1 - 0.035 13.0 0.0 0.083 11.8 0.0 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DUF2075 PF09848.4 EPA06549.1 - 0.036 13.0 0.0 0.057 12.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Syntaxin-6_N PF09177.6 EPA06549.1 - 0.037 14.4 0.0 0.087 13.2 0.0 1.6 1 0 0 1 1 1 0 Syntaxin 6, N-terminal AAA_28 PF13521.1 EPA06549.1 - 0.06 13.3 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 EPA06549.1 - 0.061 12.4 0.0 0.13 11.3 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.1 EPA06549.1 - 0.061 12.8 0.0 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 EPA06549.1 - 0.067 12.0 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_10 PF12846.2 EPA06549.1 - 0.074 12.4 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain cobW PF02492.14 EPA06549.1 - 0.092 12.1 0.0 0.19 11.1 0.0 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.9 EPA06549.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.13 EPA06549.1 - 0.11 12.0 0.0 0.3 10.5 0.0 1.8 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase DEAD PF00270.24 EPA06549.1 - 0.11 11.9 0.0 0.22 10.9 0.0 1.7 1 1 0 1 1 1 0 DEAD/DEAH box helicase Sigma54_activ_2 PF14532.1 EPA06549.1 - 0.13 12.3 0.0 0.37 10.8 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain AAA_29 PF13555.1 EPA06549.1 - 0.15 11.5 0.1 0.35 10.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AMP-binding PF00501.23 EPA06550.1 - 0.06 11.7 0.0 0.087 11.2 0.0 1.2 1 0 0 1 1 1 0 AMP-binding enzyme TrmB PF01978.14 EPA06551.1 - 4.6e-13 48.6 0.4 6.7e-13 48.1 0.3 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 EPA06551.1 - 0.00063 19.0 2.2 0.0014 17.9 0.4 2.1 1 1 1 2 2 2 1 Winged helix-turn-helix DNA-binding Rrf2 PF02082.15 EPA06551.1 - 0.0013 18.7 0.2 0.0048 16.9 0.0 1.8 2 0 0 2 2 2 1 Transcriptional regulator HTH_20 PF12840.2 EPA06551.1 - 0.0022 17.7 0.0 0.0033 17.2 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain RNA_pol_Rpb5_C PF01191.14 EPA06551.1 - 0.0032 17.0 0.2 0.0078 15.7 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb5, C-terminal domain HTH_9 PF08221.6 EPA06551.1 - 0.0094 15.7 0.1 0.021 14.7 0.1 1.6 1 1 0 1 1 1 1 RNA polymerase III subunit RPC82 helix-turn-helix domain DUF2250 PF10007.4 EPA06551.1 - 0.024 14.5 0.1 0.034 14.0 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) PadR PF03551.9 EPA06551.1 - 0.057 13.1 0.1 0.11 12.3 0.1 1.5 1 1 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_5 PF01022.15 EPA06551.1 - 0.079 12.6 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family GatB_Yqey PF02637.13 EPA06552.1 - 1.3e-29 102.8 4.1 1.5e-29 102.6 2.8 1.0 1 0 0 1 1 1 1 GatB domain TAN PF11640.3 EPA06552.1 - 0.03 14.0 0.9 0.039 13.6 0.6 1.2 1 0 0 1 1 1 0 Telomere-length maintenance and DNA damage repair MutS_III PF05192.13 EPA06552.1 - 0.064 13.0 0.1 0.073 12.8 0.1 1.2 1 0 0 1 1 1 0 MutS domain III AF0941-like PF14591.1 EPA06552.1 - 0.066 13.2 0.6 0.088 12.8 0.4 1.3 1 0 0 1 1 1 0 AF0941-like Rep_fac_C PF08542.6 EPA06552.1 - 0.13 12.2 0.6 0.54 10.2 0.2 2.0 1 1 1 2 2 2 0 Replication factor C C-terminal domain LPP20 PF02169.11 EPA06552.1 - 0.35 10.9 2.6 0.49 10.5 1.8 1.3 1 0 0 1 1 1 0 LPP20 lipoprotein Hydantoinase_A PF01968.13 EPA06554.1 - 2.2e-30 105.7 0.6 3.2e-30 105.2 0.4 1.2 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase UCR_Fe-S_N PF10399.4 EPA06554.1 - 0.23 10.6 0.3 0.48 9.6 0.2 1.5 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal tRNA-synt_2 PF00152.15 EPA06555.1 - 1.8e-48 165.0 0.5 2.3e-48 164.7 0.3 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EPA06555.1 - 1.4e-11 44.0 0.0 2.5e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Pox_F11 PF04943.7 EPA06555.1 - 0.037 12.8 0.1 0.047 12.5 0.1 1.1 1 0 0 1 1 1 0 Poxvirus F11 protein MAT1 PF06391.8 EPA06555.1 - 0.49 9.9 3.6 2.8 7.4 0.2 2.3 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 TrmB PF01978.14 EPA06556.1 - 4.2e-11 42.3 0.0 8.2e-11 41.4 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.5 EPA06556.1 - 0.005 16.4 0.0 0.0088 15.6 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_9 PF08221.6 EPA06556.1 - 0.032 14.1 0.0 0.068 13.0 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_20 PF12840.2 EPA06556.1 - 0.038 13.7 0.0 0.07 12.9 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain MarR_2 PF12802.2 EPA06556.1 - 0.18 11.5 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 MarR family AMP-binding PF00501.23 EPA06557.1 - 4.2e-64 216.4 0.0 5e-64 216.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EPA06557.1 - 8.4e-15 55.4 0.0 1.4e-14 54.7 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Acetyltransf_4 PF13420.1 EPA06557.1 - 0.053 13.4 0.1 0.19 11.6 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FTR1 PF03239.9 EPA06558.1 - 9.9e-21 73.9 20.3 2.7e-14 52.8 3.4 2.5 1 1 1 2 2 2 2 Iron permease FTR1 family Amidase PF01425.16 EPA06559.1 - 8.6e-132 440.1 0.0 9.7e-132 439.9 0.0 1.0 1 0 0 1 1 1 1 Amidase Hydant_A_N PF05378.8 EPA06560.1 - 4.8e-23 81.5 5.5 7.5e-23 80.9 3.8 1.2 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.13 EPA06560.1 - 2.8e-11 43.0 1.4 2.6e-10 39.9 0.0 2.3 2 1 0 2 2 2 1 Hydantoinase/oxoprolinase MutL PF13941.1 EPA06560.1 - 1.9e-06 26.4 1.1 2.5e-06 26.0 0.7 1.2 1 0 0 1 1 1 1 MutL protein BcrAD_BadFG PF01869.15 EPA06560.1 - 4.9e-06 26.0 0.4 5.5e-06 25.8 0.3 1.3 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family FGGY_N PF00370.16 EPA06560.1 - 1.3e-05 24.6 1.5 4.6e-05 22.8 0.9 1.9 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain HisG_C PF08029.6 EPA06560.1 - 0.038 13.9 0.0 0.086 12.7 0.0 1.5 1 0 0 1 1 1 0 HisG, C-terminal domain HAD PF12710.2 EPA06560.1 - 0.11 12.6 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Band_7_1 PF13421.1 EPA06560.1 - 0.17 11.4 1.1 3.7 7.0 0.0 2.1 2 0 0 2 2 2 0 SPFH domain-Band 7 family CGI-121 PF08617.5 EPA06560.1 - 0.39 10.3 3.5 2.5 7.7 0.5 2.8 2 1 1 3 3 3 0 Kinase binding protein CGI-121 DUF655 PF04919.7 EPA06564.1 - 8.3e-52 175.5 0.1 9.4e-52 175.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF655) HHH_6 PF14579.1 EPA06564.1 - 7.5e-05 22.7 0.0 0.00019 21.3 0.0 1.7 1 1 0 1 1 1 1 Helix-hairpin-helix motif HHH_3 PF12836.2 EPA06564.1 - 0.002 18.0 0.0 0.0051 16.7 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_24 PF13412.1 EPA06565.1 - 2.9e-06 26.5 0.0 3.2e-06 26.4 0.0 1.0 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 EPA06565.1 - 6.9e-06 25.5 0.0 7.5e-06 25.3 0.0 1.0 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain Ribosomal_60s PF00428.14 EPA06566.1 - 2.1e-12 47.2 15.5 2.4e-12 47.0 10.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein PepSY_2 PF13670.1 EPA06566.1 - 0.022 14.6 6.0 0.15 11.9 2.4 2.2 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain YusW PF14039.1 EPA06567.1 - 0.032 14.4 0.0 0.11 12.8 0.0 1.7 2 0 0 2 2 2 0 YusW-like protein YjbE PF11106.3 EPA06567.1 - 0.058 13.3 1.2 0.86 9.6 0.1 2.2 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE Oxidored_q6 PF01058.17 EPA06567.1 - 0.062 12.9 0.1 0.11 12.0 0.1 1.3 1 1 0 1 1 1 0 NADH ubiquinone oxidoreductase, 20 Kd subunit Acetyltransf_7 PF13508.1 EPA06567.1 - 0.084 13.0 0.0 2.3 8.4 0.0 2.2 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain Metallophos_2 PF12850.2 EPA06568.1 - 6.9e-21 74.7 0.1 9e-21 74.3 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 EPA06568.1 - 4.4e-17 62.1 0.4 6.1e-17 61.6 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_3 PF14582.1 EPA06568.1 - 4.9e-05 22.6 0.0 0.0052 15.9 0.0 2.1 2 0 0 2 2 2 2 Metallophosphoesterase, calcineurin superfamily DUF2124 PF09897.4 EPA06568.1 - 0.0029 17.3 0.0 0.005 16.5 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2124) SHOCT PF09851.4 EPA06570.1 - 0.13 11.7 0.4 2 7.9 0.1 2.3 2 0 0 2 2 2 0 Short C-terminal domain lci PF12197.3 EPA06570.1 - 0.26 10.9 2.4 0.64 9.6 0.7 2.2 2 0 0 2 2 2 0 Bacillus cereus group antimicrobial protein A2M_N PF01835.14 EPA06570.1 - 0.75 10.0 3.8 0.36 11.0 0.1 2.2 2 1 1 3 3 3 0 MG2 domain RNA_pol_Rpb4 PF03874.11 EPA06571.1 - 4e-14 52.6 0.8 8.7e-14 51.5 0.6 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb4 Nop PF01798.13 EPA06572.1 - 1.3e-50 170.5 1.7 2.4e-50 169.7 1.2 1.4 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 EPA06572.1 - 2.3e-20 72.1 0.0 5.5e-20 70.9 0.0 1.7 1 0 0 1 1 1 1 NOSIC (NUC001) domain Rad51 PF08423.6 EPA06573.1 - 6.6e-93 310.3 0.3 1e-92 309.7 0.0 1.4 2 0 0 2 2 2 1 Rad51 AAA_25 PF13481.1 EPA06573.1 - 2.7e-14 53.0 0.0 4.5e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 EPA06573.1 - 5.9e-10 38.7 0.1 9.8e-10 37.9 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.1 EPA06573.1 - 2.4e-09 37.2 0.9 2.5e-08 33.9 0.1 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix domain KaiC PF06745.8 EPA06573.1 - 1.6e-08 33.9 0.1 3.2e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.1 EPA06573.1 - 0.043 13.9 0.0 0.089 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain NARP1 PF12569.3 EPA06573.1 - 0.4 9.3 8.5 0.61 8.7 5.9 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Herpes_UL74 PF07982.7 EPA06574.1 - 0.0045 15.7 0.5 0.014 14.1 0.1 1.8 2 0 0 2 2 2 1 Herpes UL74 glycoproteins Ribosomal_S30 PF04758.9 EPA06575.1 - 1.5e-07 31.0 6.3 3e-07 30.0 4.4 1.8 1 1 0 1 1 1 1 Ribosomal protein S30 NAD_binding_1 PF00175.16 EPA06576.1 - 3.3e-15 56.5 0.1 6.1e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DHODB_Fe-S_bind PF10418.4 EPA06576.1 - 1.5e-10 40.3 8.6 2.8e-10 39.4 5.9 1.5 1 0 0 1 1 1 1 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B FAD_binding_6 PF00970.19 EPA06576.1 - 2.4e-07 30.7 0.0 5.1e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 EPA06576.1 - 0.5 10.2 2.9 16 5.3 0.0 2.8 3 0 0 3 3 3 0 Ferric reductase NAD binding domain HATPase_c PF02518.21 EPA06577.1 - 2.2e-20 72.4 0.1 4.6e-20 71.3 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EPA06577.1 - 2.4e-12 46.6 0.1 5.2e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.20 EPA06577.1 - 2.3e-07 30.8 0.5 1.3e-06 28.4 0.0 2.5 3 0 0 3 3 3 1 HAMP domain HATPase_c_5 PF14501.1 EPA06577.1 - 2.9e-07 30.1 0.1 2.9e-07 30.1 0.1 2.8 3 0 0 3 3 3 1 GHKL domain DUF4234 PF14018.1 EPA06577.1 - 0.071 12.8 0.5 0.2 11.4 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) UPF0126 PF03458.8 EPA06578.1 - 3.7e-43 145.0 23.8 1.5e-22 78.9 3.8 2.3 2 0 0 2 2 2 2 UPF0126 domain Ribosomal_L21e PF01157.13 EPA06579.1 - 5.4e-14 51.8 1.6 7.3e-14 51.3 1.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L21e Radical_SAM PF04055.16 EPA06580.1 - 2.1e-08 34.5 0.0 5.8e-08 33.0 0.0 1.9 1 0 0 1 1 1 1 Radical SAM superfamily Ribosomal_L10 PF00466.15 EPA06581.1 - 7.6e-18 64.2 0.6 7.6e-18 64.2 0.4 2.0 2 1 0 2 2 2 1 Ribosomal protein L10 DHO_dh PF01180.16 EPA06582.1 - 2.5e-56 190.8 1.1 2.9e-56 190.6 0.8 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Dus PF01207.12 EPA06582.1 - 3.7e-06 26.0 0.2 0.0019 17.0 0.0 2.0 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) His_biosynth PF00977.16 EPA06582.1 - 9.7e-06 25.0 0.4 0.032 13.5 0.0 2.7 3 0 0 3 3 3 2 Histidine biosynthesis protein DUF561 PF04481.7 EPA06582.1 - 0.00014 20.8 8.4 0.00038 19.4 0.0 3.6 3 1 0 4 4 4 1 Protein of unknown function (DUF561) NMO PF03060.10 EPA06582.1 - 0.00031 19.9 0.4 0.0076 15.4 0.0 2.0 1 1 1 2 2 2 1 Nitronate monooxygenase ThiG PF05690.9 EPA06582.1 - 0.0018 17.3 2.8 0.23 10.5 0.4 2.7 2 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG IMPDH PF00478.20 EPA06582.1 - 0.009 14.9 0.4 0.021 13.7 0.0 1.7 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain PcrB PF01884.12 EPA06582.1 - 0.035 13.3 2.0 0.6 9.3 0.0 2.9 3 1 0 3 3 3 0 PcrB family G3P_antiterm PF04309.7 EPA06582.1 - 0.059 12.3 1.1 3 6.8 0.0 2.5 3 0 0 3 3 3 0 Glycerol-3-phosphate responsive antiterminator Antimicrobial_8 PF08103.6 EPA06582.1 - 0.067 13.1 0.0 0.23 11.4 0.0 2.0 1 0 0 1 1 1 0 Uperin family Methyltransf_31 PF13847.1 EPA06583.1 - 3.3e-09 36.4 0.5 1.5e-08 34.3 0.3 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA06583.1 - 2.2e-08 33.9 0.0 1.4e-07 31.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EPA06583.1 - 1.2e-07 31.2 0.0 2e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.7 EPA06583.1 - 2.4e-06 27.9 0.1 9.1e-06 26.0 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EPA06583.1 - 1e-05 25.5 0.0 2.1e-05 24.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA06583.1 - 4.5e-05 23.8 0.1 0.00013 22.3 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA06583.1 - 0.00013 22.5 0.0 0.00059 20.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EPA06583.1 - 0.00032 20.3 0.0 0.00086 18.8 0.0 1.7 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.13 EPA06583.1 - 0.0017 17.5 0.1 0.0023 17.0 0.1 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family RrnaAD PF00398.15 EPA06583.1 - 0.0034 16.4 0.0 0.0051 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.1 EPA06583.1 - 0.0045 17.3 0.1 0.049 13.9 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 EPA06583.1 - 0.0047 16.6 0.0 0.0075 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EPA06583.1 - 0.043 12.9 0.1 0.1 11.7 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Bin3 PF06859.7 EPA06583.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Bicoid-interacting protein 3 (Bin3) Aha1_N PF09229.6 EPA06584.1 - 0.011 15.5 0.9 0.013 15.3 0.6 1.2 1 0 0 1 1 1 0 Activator of Hsp90 ATPase, N-terminal DUF4325 PF14213.1 EPA06584.1 - 0.1 12.2 1.1 0.8 9.3 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4325) Fib_alpha PF08702.5 EPA06586.1 - 0.015 15.3 0.2 0.018 15.1 0.1 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DivIC PF04977.10 EPA06587.1 - 0.0031 16.9 1.4 0.0043 16.4 1.0 1.4 1 1 0 1 1 1 1 Septum formation initiator HCR PF07111.7 EPA06587.1 - 0.061 11.3 0.1 0.066 11.2 0.1 1.0 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) DUF904 PF06005.7 EPA06587.1 - 0.088 13.1 0.4 0.096 12.9 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DUF1192 PF06698.6 EPA06587.1 - 0.095 12.5 2.8 0.28 11.0 1.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1192) TSC22 PF01166.13 EPA06587.1 - 0.095 12.6 0.7 0.16 11.9 0.5 1.4 1 1 0 1 1 1 0 TSC-22/dip/bun family bZIP_2 PF07716.10 EPA06587.1 - 0.12 12.1 0.9 0.23 11.3 0.1 1.7 1 1 1 2 2 2 0 Basic region leucine zipper Radical_SAM PF04055.16 EPA06588.1 - 4e-14 53.1 0.0 8e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.1 EPA06588.1 - 2e-05 24.5 0.0 3.6e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 EPA06588.1 - 0.011 15.8 0.0 0.026 14.6 0.0 1.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain Iso_dh PF00180.15 EPA06590.1 - 1.1e-82 277.7 0.5 1.3e-82 277.5 0.3 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Response_reg PF00072.19 EPA06591.1 - 1.9e-21 76.1 0.9 2.2e-21 75.9 0.6 1.0 1 0 0 1 1 1 1 Response regulator receiver domain RrnaAD PF00398.15 EPA06592.1 - 7.4e-40 136.6 0.4 8.5e-40 136.4 0.3 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.1 EPA06592.1 - 1.1e-06 28.2 2.0 0.0005 19.6 0.0 2.1 1 1 1 2 2 2 2 Methyltransferase domain PCMT PF01135.14 EPA06592.1 - 6.3e-05 22.5 0.0 0.00013 21.6 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.2 EPA06592.1 - 0.00023 21.6 0.0 0.00038 21.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EPA06592.1 - 0.00053 20.0 0.0 0.00072 19.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA06592.1 - 0.0084 15.8 0.0 0.018 14.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 EPA06592.1 - 0.015 14.6 0.0 0.03 13.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_12 PF08242.7 EPA06592.1 - 0.028 14.9 0.0 0.093 13.2 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.7 EPA06592.1 - 0.074 13.5 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Transglut_core2 PF13369.1 EPA06593.1 - 1.5e-39 134.9 0.0 2.2e-39 134.3 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily TPR_9 PF13371.1 EPA06593.1 - 1.5e-14 53.5 0.0 2.5e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EPA06593.1 - 0.00023 20.9 0.1 0.59 10.0 0.0 2.8 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.23 EPA06593.1 - 0.00053 19.4 0.1 1.2 8.9 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 EPA06593.1 - 0.032 13.8 0.1 0.06 12.9 0.0 1.5 1 0 0 1 1 1 0 TPR repeat YfzA PF14118.1 EPA06593.1 - 0.094 12.8 0.1 15 5.7 0.0 2.6 2 0 0 2 2 2 0 YfzA-like protein TPR_2 PF07719.12 EPA06593.1 - 0.11 12.4 0.0 25 5.0 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Methyltransf_11 PF08241.7 EPA06594.1 - 6.1e-09 36.2 0.0 1.1e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA06594.1 - 8.3e-09 35.3 0.0 1.2e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EPA06594.1 - 6.6e-08 32.9 0.0 1.7e-07 31.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA06594.1 - 1.1e-07 31.5 0.0 1.8e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.7 EPA06594.1 - 7.7e-07 28.2 1.2 1.2e-06 27.6 0.3 1.4 1 1 1 2 2 2 1 DREV methyltransferase Methyltransf_18 PF12847.2 EPA06594.1 - 4.6e-06 27.1 0.0 9.8e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EPA06594.1 - 6.9e-05 22.2 0.0 0.00024 20.5 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase small domain Trm112p PF03966.11 EPA06594.1 - 0.00027 21.2 0.8 0.0025 18.1 0.3 2.7 3 1 0 3 3 3 1 Trm112p-like protein TehB PF03848.9 EPA06594.1 - 0.00063 18.9 0.2 0.001 18.2 0.1 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB NodS PF05401.6 EPA06594.1 - 0.0012 18.3 0.0 0.003 16.9 0.0 1.6 1 1 0 1 1 1 1 Nodulation protein S (NodS) zf-CSL PF05207.8 EPA06594.1 - 0.0022 17.4 1.0 0.0051 16.3 0.7 1.6 1 0 0 1 1 1 1 CSL zinc finger Ribosomal_L1 PF00687.16 EPA06596.1 - 8.1e-43 146.3 1.6 9.8e-43 146.0 1.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF1439 PF07273.7 EPA06596.1 - 0.064 12.9 0.5 1.8 8.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1439) OrfB_Zn_ribbon PF07282.6 EPA06599.1 - 0.0079 15.8 0.3 0.0085 15.7 0.2 1.1 1 0 0 1 1 1 1 Putative transposase DNA-binding domain PhnA_Zn_Ribbon PF08274.7 EPA06599.1 - 0.013 15.3 1.0 0.65 9.8 0.1 2.1 2 0 0 2 2 2 0 PhnA Zinc-Ribbon zf-RING_4 PF14570.1 EPA06599.1 - 0.057 13.0 3.6 3.5 7.2 0.1 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zinc_ribbon_5 PF13719.1 EPA06599.1 - 0.09 12.3 0.4 1.7 8.3 0.0 2.1 2 0 0 2 2 2 0 zinc-ribbon domain DUF4451 PF14616.1 EPA06599.1 - 0.11 12.2 2.1 0.57 9.9 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4451) IBR PF01485.16 EPA06599.1 - 0.12 12.2 1.0 0.2 11.5 0.7 1.4 1 1 0 1 1 1 0 IBR domain zf-DBF PF07535.7 EPA06599.1 - 0.3 10.7 1.7 0.51 10.0 0.4 1.8 2 0 0 2 2 2 0 DBF zinc finger zf-Apc11 PF12861.2 EPA06599.1 - 0.41 10.4 1.8 15 5.5 0.1 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.1 EPA06599.1 - 0.51 10.1 2.4 3.3 7.4 0.2 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zn-ribbon_8 PF09723.5 EPA06599.1 - 1.3 9.0 3.7 9.8 6.2 1.0 2.2 2 0 0 2 2 2 0 Zinc ribbon domain AMMECR1 PF01871.12 EPA06600.1 - 6.1e-24 84.0 0.0 7.1e-24 83.8 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 DUF126 PF01989.11 EPA06601.1 - 0.0014 18.2 0.1 0.002 17.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF126 DUF126 PF01989.11 EPA06602.1 - 1.6e-06 27.6 0.0 2.5e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function DUF126 E1-E2_ATPase PF00122.15 EPA06603.1 - 6.8e-49 165.9 0.4 8.8e-49 165.6 0.3 1.2 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EPA06603.1 - 5.1e-08 33.5 0.0 1.3e-07 32.2 0.0 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF1402 PF07182.6 EPA06603.1 - 0.037 12.9 0.0 0.053 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1402) ABC_membrane PF00664.18 EPA06603.1 - 0.13 11.6 0.6 0.19 11.1 0.4 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region E1-E2_ATPase PF00122.15 EPA06604.1 - 6.8e-49 165.9 0.4 8.8e-49 165.6 0.3 1.1 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EPA06604.1 - 5.2e-08 33.5 0.0 1.3e-07 32.2 0.0 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF1402 PF07182.6 EPA06604.1 - 0.037 12.9 0.0 0.053 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1402) ABC_membrane PF00664.18 EPA06604.1 - 0.13 11.6 0.6 0.19 11.1 0.4 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region C5-epim_C PF06662.8 EPA06605.1 - 3.6e-10 39.4 4.0 0.044 13.0 0.0 4.1 4 0 0 4 4 4 3 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_88 PF07470.8 EPA06605.1 - 1.1e-07 31.1 0.0 0.045 12.7 0.0 3.3 2 2 1 3 3 3 3 Glycosyl Hydrolase Family 88 DUF1680 PF07944.7 EPA06605.1 - 2.4e-05 22.8 0.5 0.16 10.2 0.0 3.3 2 1 1 3 3 3 2 Putative glycosyl hydrolase of unknown function (DUF1680) Glyco_hydro_76 PF03663.9 EPA06605.1 - 3.6e-05 23.3 0.1 0.048 13.0 0.0 3.1 2 1 0 2 2 2 2 Glycosyl hydrolase family 76 GlcNAc_2-epim PF07221.6 EPA06605.1 - 0.00011 21.4 0.2 3.8 6.4 0.0 3.7 2 1 2 4 4 4 2 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) LANC_like PF05147.8 EPA06605.1 - 0.00035 19.2 0.2 0.37 9.3 0.0 3.8 3 1 1 4 4 4 1 Lanthionine synthetase C-like protein Glyco_hydro_47 PF01532.15 EPA06605.1 - 0.0011 17.7 0.1 0.29 9.7 0.0 3.1 2 1 0 3 3 3 1 Glycosyl hydrolase family 47 Pec_lyase PF09492.5 EPA06605.1 - 0.06 12.5 0.1 0.43 9.7 0.0 2.1 2 0 0 2 2 2 0 Pectic acid lyase DUF3294 PF07957.6 EPA06606.1 - 0.1 12.1 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3294) FAINT PF04385.10 EPA06606.1 - 0.11 12.3 0.2 0.73 9.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function, DUF529 Na_H_Exchanger PF00999.16 EPA06607.1 - 4.6e-57 193.2 54.4 6e-57 192.9 37.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family CBS PF00571.23 EPA06607.1 - 1.5e-12 47.0 0.1 8.8e-07 28.6 0.0 2.6 2 0 0 2 2 2 2 CBS domain PP_kinase_N PF13089.1 EPA06609.1 - 0.07 13.2 0.4 0.084 12.9 0.2 1.1 1 0 0 1 1 1 0 Polyphosphate kinase N-terminal domain Viral_env_E26 PF11050.3 EPA06609.1 - 0.41 9.7 3.6 0.5 9.5 2.4 1.3 1 1 0 1 1 1 0 Virus envelope protein E26 Sds3 PF08598.6 EPA06609.1 - 0.82 9.1 4.6 0.58 9.6 1.6 1.6 1 1 1 2 2 2 0 Sds3-like Myosin_tail_1 PF01576.14 EPA06611.1 - 0.0022 15.7 0.4 0.0026 15.5 0.3 1.1 1 0 0 1 1 1 1 Myosin tail WXG100 PF06013.7 EPA06611.1 - 0.0085 16.0 0.5 0.015 15.2 0.4 1.4 1 0 0 1 1 1 1 Proteins of 100 residues with WXG DUF1413 PF07205.6 EPA06611.1 - 0.031 13.8 1.4 0.77 9.3 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF1413) DUF4446 PF14584.1 EPA06611.1 - 0.081 12.7 0.2 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Bac_small_YrzI PF09501.5 EPA06611.1 - 0.2 11.5 2.6 5.1 7.0 0.8 2.4 2 0 0 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) DUF3139 PF11337.3 EPA06611.1 - 0.97 9.7 5.9 0.28 11.4 1.3 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3139) 4HB_MCP_1 PF12729.2 EPA06611.1 - 2.3 7.5 7.0 14 5.0 1.4 2.8 2 1 1 3 3 3 0 Four helix bundle sensory module for signal transduction Usp PF00582.21 EPA06614.1 - 5.1e-08 33.2 0.0 5.3e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family DUF1400 PF07176.6 EPA06614.1 - 0.086 12.7 0.0 0.091 12.6 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1400) Thioredox_DsbH PF03190.10 EPA06615.1 - 4.2e-77 257.4 0.1 5e-77 257.2 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.1 EPA06615.1 - 6.7e-15 54.8 0.1 1.2e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 EPA06615.1 - 2.7e-05 24.3 0.2 8.1e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin-like domain TruD PF01142.13 EPA06616.1 - 2e-26 92.5 0.0 2.3e-26 92.3 0.0 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) GCC2_GCC3 PF07699.8 EPA06617.1 - 0.00084 18.8 1.7 0.00093 18.7 1.2 1.2 1 0 0 1 1 1 1 GCC2 and GCC3 PADR1 PF08063.7 EPA06617.1 - 0.053 12.9 2.3 0.076 12.4 0.1 1.9 1 1 1 2 2 2 0 PADR1 (NUC008) domain Cytochrom_c3_2 PF14537.1 EPA06617.1 - 0.11 12.9 1.4 0.11 12.8 1.0 1.1 1 0 0 1 1 1 0 Cytochrome c3 DnaJ_CXXCXGXG PF00684.14 EPA06617.1 - 0.13 12.3 4.9 0.41 10.7 3.5 1.5 1 1 0 1 1 1 0 DnaJ central domain TFIIS_C PF01096.13 EPA06617.1 - 0.2 11.3 3.5 0.34 10.5 0.2 2.0 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) HypA PF01155.14 EPA06617.1 - 0.21 11.2 1.7 0.23 11.1 1.2 1.0 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-RanBP PF00641.13 EPA06617.1 - 0.66 9.1 4.0 2.4 7.3 0.1 2.2 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others XPA_N PF01286.13 EPA06617.1 - 0.76 9.5 5.8 0.44 10.2 0.8 2.2 2 0 0 2 2 2 0 XPA protein N-terminal Helicase_C_2 PF13307.1 EPA06620.1 - 8.3e-22 77.8 0.0 2.1e-21 76.6 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.10 EPA06620.1 - 4.4e-06 26.2 1.4 7.1e-06 25.5 0.2 1.9 2 0 0 2 2 2 1 DEAD_2 DUF3247 PF11607.3 EPA06620.1 - 0.12 12.5 0.0 0.36 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) GIY-YIG PF01541.19 EPA06622.1 - 8.4e-08 32.4 0.2 1.1e-07 32.1 0.2 1.2 1 0 0 1 1 1 1 GIY-YIG catalytic domain Tubulin PF00091.20 EPA06623.1 - 1.6e-10 41.1 0.0 1.9e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain MtN3_slv PF03083.11 EPA06624.1 - 3.5e-08 33.1 3.3 3.9e-08 33.0 2.3 1.1 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange PQ-loop PF04193.9 EPA06624.1 - 7e-05 22.2 4.2 7e-05 22.2 2.9 1.5 2 0 0 2 2 2 1 PQ loop repeat DUF4389 PF14333.1 EPA06624.1 - 0.018 14.7 2.5 0.52 10.0 0.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) 7TM-7TMR_HD PF07698.6 EPA06624.1 - 0.081 12.3 4.5 0.1 12.0 3.1 1.2 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DUF3784 PF12650.2 EPA06624.1 - 0.1 12.5 12.8 3 7.8 8.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3784) Syndecan PF01034.15 EPA06624.1 - 0.54 9.9 3.1 1.1 8.9 2.2 1.7 1 1 0 1 1 1 0 Syndecan domain VirB3 PF05101.8 EPA06624.1 - 0.93 9.5 7.2 0.71 9.8 1.7 2.1 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein DUF3487 PF11990.3 EPA06624.1 - 0.98 8.8 4.6 1.4 8.3 1.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) dCMP_cyt_deam_1 PF00383.17 EPA06625.1 - 2.1e-25 88.3 1.3 3e-25 87.8 0.9 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region PEP-utilizers_C PF02896.13 EPA06626.1 - 1.8e-89 299.5 0.6 3e-89 298.7 0.4 1.4 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.14 EPA06626.1 - 1.2e-61 208.5 0.0 9.3e-61 205.6 0.0 2.3 2 1 0 2 2 2 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers PF00391.18 EPA06626.1 - 1.9e-23 81.8 0.3 6.1e-23 80.1 0.2 1.9 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain Snf7 PF03357.16 EPA06627.1 - 2.2e-07 30.4 0.0 2.8e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Snf7 DASH_Dam1 PF08653.5 EPA06627.1 - 0.00032 20.3 0.1 2.6 7.8 0.1 3.5 2 1 2 4 4 4 2 DASH complex subunit Dam1 Baculo_PEP_C PF04513.7 EPA06627.1 - 0.051 13.3 0.6 1 9.2 0.0 2.2 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Abhydrolase_4 PF08386.5 EPA06628.1 - 0.038 13.8 0.0 0.047 13.5 0.0 1.2 1 0 0 1 1 1 0 TAP-like protein zf-CDGSH PF09360.5 EPA06629.1 - 8.9e-13 47.8 0.9 1e-12 47.6 0.7 1.1 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type DNA_pol_B PF00136.16 EPA06630.1 - 2.8e-70 237.4 2.9 4.2e-70 236.8 2.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 EPA06630.1 - 8.1e-40 136.6 2.6 1.3e-39 135.9 1.8 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain RNase_H_2 PF13482.1 EPA06630.1 - 7.7e-07 29.0 4.4 9.9e-07 28.7 1.7 2.2 2 1 0 2 2 2 1 RNase_H superfamily DNA_pol_B_exo2 PF10108.4 EPA06630.1 - 5.3e-06 26.1 2.0 2.2e-05 24.1 1.4 2.0 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB zf-C2H2 PF00096.21 EPA06631.1 - 0.0012 19.0 0.5 0.0021 18.2 0.4 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EPA06631.1 - 0.0017 18.5 0.9 0.002 18.3 0.1 1.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_3 PF13878.1 EPA06631.1 - 0.0032 16.9 0.1 0.0053 16.3 0.1 1.4 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO DUF2688 PF10892.3 EPA06631.1 - 0.0073 15.9 0.2 0.008 15.8 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2688) zf-C2H2_2 PF12756.2 EPA06631.1 - 0.013 15.6 1.8 0.014 15.5 1.3 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.1 EPA06631.1 - 0.013 15.7 6.2 0.12 12.6 1.0 2.1 2 0 0 2 2 2 0 Zinc-finger double domain zf-BED PF02892.10 EPA06631.1 - 0.064 13.0 2.6 0.071 12.8 1.8 1.4 1 0 0 1 1 1 0 BED zinc finger zf-C2H2_6 PF13912.1 EPA06631.1 - 0.069 13.0 0.3 0.1 12.5 0.2 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger DUF629 PF04780.7 EPA06631.1 - 0.12 10.8 1.1 0.11 11.0 0.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) Glyoxalase_2 PF12681.2 EPA06633.1 - 5.6e-13 49.4 0.0 1e-12 48.5 0.0 1.4 2 0 0 2 2 2 1 Glyoxalase-like domain Glyoxalase PF00903.20 EPA06633.1 - 1.5e-07 31.4 0.0 2.4e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DNA_pol_B PF00136.16 EPA06634.1 - 1.7e-06 27.1 0.1 1.7e-06 27.0 0.1 1.0 1 0 0 1 1 1 1 DNA polymerase family B DDE_3 PF13358.1 EPA06634.1 - 0.05 13.3 0.0 0.057 13.1 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease TIM PF00121.13 EPA06635.1 - 1.1e-28 99.9 6.5 2.6e-26 92.1 4.5 2.0 1 1 0 1 1 1 1 Triosephosphate isomerase ThiG PF05690.9 EPA06635.1 - 1.9e-05 23.8 0.1 3e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG FMN_dh PF01070.13 EPA06635.1 - 0.00035 19.5 0.0 0.00057 18.8 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IGPS PF00218.16 EPA06635.1 - 0.00071 18.7 0.1 0.0018 17.3 0.1 1.7 1 1 0 1 1 1 1 Indole-3-glycerol phosphate synthase POC1 PF10450.4 EPA06635.1 - 0.028 13.1 0.2 0.068 11.9 0.1 1.6 1 1 0 1 1 1 0 POC1 chaperone NMO PF03060.10 EPA06635.1 - 0.051 12.7 0.0 0.08 12.0 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase Glu_synthase PF01645.12 EPA06635.1 - 0.082 11.8 2.5 0.79 8.5 1.7 2.2 1 1 0 1 1 1 0 Conserved region in glutamate synthase PcrB PF01884.12 EPA06635.1 - 0.31 10.2 5.2 0.17 11.1 0.6 2.3 1 1 0 2 2 2 0 PcrB family GARS_A PF01071.14 EPA06636.1 - 1.3e-78 263.0 0.2 1.7e-78 262.6 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.10 EPA06636.1 - 1.8e-33 114.9 0.0 3.9e-33 113.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.11 EPA06636.1 - 4.2e-30 103.7 0.0 7.8e-30 102.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp_4 PF13535.1 EPA06636.1 - 1.3e-11 44.5 0.0 2.3e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.17 EPA06636.1 - 1e-07 31.4 0.0 1.9e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_2 PF08442.5 EPA06636.1 - 1.4e-06 27.8 0.1 2.4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 EPA06636.1 - 3.3e-06 27.0 0.0 6.4e-06 26.1 0.0 1.5 1 1 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EPA06636.1 - 1.9e-05 24.1 0.0 2.7e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.12 EPA06636.1 - 5.1e-05 22.6 0.1 0.00022 20.5 0.1 2.1 2 1 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_Ter PF15632.1 EPA06636.1 - 9.5e-05 21.2 0.0 0.0016 17.2 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.6 EPA06636.1 - 0.00017 21.1 0.0 0.00062 19.2 0.0 1.9 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATPgrasp_ST PF14397.1 EPA06636.1 - 0.014 14.5 0.4 0.13 11.2 0.0 2.4 2 1 1 3 3 3 0 Sugar-transfer associated ATP-grasp DUF2669 PF10876.3 EPA06636.1 - 0.056 13.1 0.1 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2669) ATP-grasp_5 PF13549.1 EPA06636.1 - 0.07 12.3 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain DUF4182 PF13790.1 EPA06636.1 - 0.14 11.9 0.1 0.32 10.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4182) ATP-grasp_2 PF08442.5 EPA06637.1 - 4e-46 156.9 0.8 7.2e-46 156.1 0.6 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 EPA06637.1 - 1.6e-15 56.9 1.5 2.1e-15 56.6 0.2 1.8 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.1 EPA06637.1 - 1.3e-12 47.4 0.1 5.6e-12 45.3 0.1 2.0 1 1 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.12 EPA06637.1 - 1.3e-05 24.6 0.0 2.2e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.1 EPA06637.1 - 0.0004 20.1 0.0 0.00072 19.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain DUF362 PF04015.7 EPA06637.1 - 0.022 14.2 0.0 0.12 11.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF362) ATP-grasp PF02222.17 EPA06637.1 - 0.09 12.1 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain ABM PF03992.11 EPA06638.1 - 1.6e-06 28.0 0.0 2.3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF1330 PF07045.6 EPA06638.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1330) THF_DHG_CYH_C PF02882.14 EPA06640.1 - 9.2e-59 197.1 1.0 1.3e-58 196.6 0.7 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 EPA06640.1 - 5.4e-41 139.2 1.4 5.4e-41 139.2 0.9 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain SIMPL PF04402.9 EPA06640.1 - 0.021 14.7 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF541) DUF1884 PF08967.5 EPA06640.1 - 0.031 14.3 0.7 0.15 12.1 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1884) tRNA_bind PF01588.15 EPA06641.1 - 0.12 12.2 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative tRNA binding domain 5-FTHF_cyc-lig PF01812.15 EPA06643.1 - 5.3e-40 137.1 0.0 5.9e-40 137.0 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Ferritin PF00210.19 EPA06644.1 - 2.2e-18 66.4 0.1 3e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.12 EPA06644.1 - 0.024 14.9 0.0 0.036 14.3 0.0 1.3 1 0 0 1 1 1 0 Rubrerythrin Cupin_2 PF07883.6 EPA06645.1 - 3.9e-09 35.8 0.0 4.1e-09 35.7 0.0 1.0 1 0 0 1 1 1 1 Cupin domain CENP-C_C PF11699.3 EPA06645.1 - 6.1e-05 22.9 0.0 6.5e-05 22.8 0.0 1.0 1 0 0 1 1 1 1 Mif2/CENP-C like AraC_binding PF02311.14 EPA06645.1 - 0.00084 19.0 0.0 0.0009 18.9 0.0 1.1 1 0 0 1 1 1 1 AraC-like ligand binding domain 3-HAO PF06052.7 EPA06645.1 - 0.0071 15.7 0.1 0.0097 15.3 0.1 1.3 1 1 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Pirin_C PF05726.8 EPA06645.1 - 0.019 15.0 0.0 0.024 14.7 0.0 1.0 1 0 0 1 1 1 0 Pirin C-terminal cupin domain Ectoine_synth PF06339.7 EPA06645.1 - 0.06 13.2 0.0 0.068 13.0 0.0 1.1 1 0 0 1 1 1 0 Ectoine synthase Auxin_BP PF02041.11 EPA06645.1 - 0.094 12.1 0.0 0.097 12.1 0.0 1.2 1 0 0 1 1 1 0 Auxin binding protein tRNA-synt_1 PF00133.17 EPA06646.1 - 1.6e-143 478.8 0.2 2.3e-143 478.3 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 EPA06646.1 - 6.5e-32 110.4 1.0 1.6e-31 109.1 0.7 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 EPA06646.1 - 9.4e-25 87.0 2.5 1.3e-09 37.1 0.1 4.3 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 EPA06646.1 - 6.9e-06 25.3 0.0 0.00013 21.1 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.13 EPA06646.1 - 0.00047 18.9 0.4 0.0019 16.9 0.0 2.3 3 0 0 3 3 3 1 tRNA synthetases class I (K) CoA_binding PF02629.14 EPA06647.1 - 1.9e-21 76.3 3.8 2.1e-21 76.2 0.9 2.3 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.14 EPA06647.1 - 1e-08 34.9 0.2 1.7e-08 34.1 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase CoA_binding_2 PF13380.1 EPA06647.1 - 4.8e-06 26.7 0.0 8.2e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 CoA binding domain Succ_CoA_lig PF13607.1 EPA06647.1 - 0.00013 21.6 0.0 0.00022 20.8 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain GFO_IDH_MocA PF01408.17 EPA06647.1 - 0.00023 21.6 0.1 0.00042 20.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Ribul_P_3_epim PF00834.14 EPA06647.1 - 0.071 12.2 0.1 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Formyl_trans_N PF00551.14 EPA06648.1 - 2.4e-51 173.8 0.0 2.7e-51 173.6 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase DUF521 PF04412.8 EPA06649.1 - 3.3e-60 203.7 0.1 5.3e-60 203.0 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF521) DNA_RNApol_7kD PF03604.8 EPA06650.1 - 0.0005 19.4 2.2 0.0011 18.3 1.6 1.6 1 1 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit GTP_EFTU PF00009.22 EPA06651.1 - 1.1e-47 161.8 0.1 1.6e-47 161.4 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EPA06651.1 - 1.2e-31 108.7 0.7 3.6e-31 107.2 0.2 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EPA06651.1 - 4.9e-17 61.8 1.2 1.3e-16 60.4 0.8 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 EPA06651.1 - 6.6e-08 32.0 0.8 1.4e-07 31.0 0.6 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 EPA06651.1 - 0.0035 17.2 0.0 0.0088 15.9 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EPA06651.1 - 0.07 13.6 0.1 0.27 11.7 0.0 2.1 2 1 0 2 2 2 0 Miro-like protein FBPase_3 PF01950.11 EPA06652.1 - 2.4e-151 503.8 0.1 2.7e-151 503.7 0.0 1.0 1 0 0 1 1 1 1 Fructose-1,6-bisphosphatase Ribosomal_S10 PF00338.17 EPA06653.1 - 1.4e-25 88.9 0.0 1.5e-25 88.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e MAF_flag10 PF01973.13 EPA06654.1 - 7.1e-29 100.4 0.5 9.8e-29 100.0 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF115 TPK_catalytic PF04263.11 EPA06654.1 - 0.014 14.9 0.4 1.3 8.5 0.1 2.3 1 1 1 2 2 2 0 Thiamin pyrophosphokinase, catalytic domain IATP PF04568.7 EPA06655.1 - 0.15 12.0 1.7 0.24 11.4 1.2 1.3 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP HATPase_c PF02518.21 EPA06656.1 - 4.3e-22 77.9 1.0 1.6e-21 76.0 0.1 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EPA06656.1 - 8.1e-09 35.3 0.0 2e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.1 EPA06656.1 - 7.2e-06 25.6 0.3 7.2e-06 25.6 0.2 2.6 2 2 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.1 EPA06656.1 - 0.00014 21.5 2.3 0.00015 21.4 0.0 2.3 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2252 PF10009.4 EPA06656.1 - 0.25 10.2 4.4 0.38 9.6 3.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) DDE_Tnp_IS66 PF03050.9 EPA06656.1 - 1.2 8.3 4.3 9.4 5.3 2.1 2.1 2 0 0 2 2 2 0 Transposase IS66 family Iron_permease PF04120.7 EPA06657.1 - 0.00084 18.9 1.2 0.00089 18.8 0.8 1.0 1 0 0 1 1 1 1 Low affinity iron permease OmpH PF03938.9 EPA06657.1 - 0.025 14.5 0.8 0.027 14.4 0.5 1.0 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Occludin_ELL PF07303.8 EPA06657.1 - 0.026 15.2 0.8 0.029 15.0 0.5 1.0 1 0 0 1 1 1 0 Occludin homology domain Mnd1 PF03962.10 EPA06657.1 - 0.041 13.5 0.9 0.044 13.4 0.6 1.0 1 0 0 1 1 1 0 Mnd1 family HHH_2 PF12826.2 EPA06657.1 - 0.05 13.4 0.2 0.24 11.2 0.1 1.9 1 1 1 2 2 2 0 Helix-hairpin-helix motif FliG_M PF14841.1 EPA06657.1 - 0.062 13.3 0.2 0.069 13.1 0.1 1.1 1 0 0 1 1 1 0 FliG middle domain PspB PF06667.7 EPA06657.1 - 0.064 13.1 0.7 0.11 12.4 0.3 1.6 1 1 1 2 2 2 0 Phage shock protein B RPAP3_C PF13877.1 EPA06657.1 - 0.084 12.8 0.1 0.14 12.1 0.0 1.3 1 1 0 1 1 1 0 Potential Monad-binding region of RPAP3 DUF2959 PF11172.3 EPA06657.1 - 0.087 12.5 0.1 0.092 12.5 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) DUF310 PF03750.8 EPA06657.1 - 0.1 12.8 0.3 0.1 12.7 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF310) Gag_p30 PF02093.11 EPA06657.1 - 0.15 11.2 0.3 0.16 11.1 0.2 1.0 1 0 0 1 1 1 0 Gag P30 core shell protein HATPase_c PF02518.21 EPA06658.1 - 2.8e-24 84.9 0.1 4.8e-24 84.2 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EPA06658.1 - 4.7e-11 42.5 0.0 9.4e-11 41.5 0.0 1.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.1 EPA06658.1 - 5.5e-07 29.2 1.3 1.4e-06 27.9 0.2 2.2 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.1 EPA06658.1 - 0.0011 18.6 0.0 0.0037 16.9 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase bPH_5 PF10882.3 EPA06658.1 - 0.032 14.0 0.9 0.78 9.5 0.0 2.8 2 1 0 2 2 2 0 Bacterial PH domain HATPase_c_2 PF13581.1 EPA06658.1 - 0.061 13.1 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain RNase_PH_C PF03725.10 EPA06658.1 - 0.46 10.4 2.7 0.64 10.0 0.2 2.4 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 Coa1 PF08695.5 EPA06659.1 - 0.062 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Cytochrome oxidase complex assembly protein 1 Atg14 PF10186.4 EPA06659.1 - 0.6 9.0 12.9 1.1 8.1 1.6 2.2 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 EPA06659.1 - 4.3 6.8 19.0 0.35 10.4 0.8 3.1 2 1 0 2 2 2 0 IncA protein ETRAMP PF09716.5 EPA06659.1 - 9.1 6.3 7.9 0.49 10.3 0.4 2.6 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) F420_ligase PF01996.11 EPA06660.1 - 5.7e-18 64.8 0.1 6.5e-18 64.6 0.1 1.0 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase SelB-wing_2 PF09106.6 EPA06660.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Elongation factor SelB, winged helix AAA_23 PF13476.1 EPA06661.1 - 0.00093 19.5 0.2 0.00099 19.4 0.1 1.0 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 EPA06661.1 - 0.0086 16.3 0.1 0.01 16.1 0.1 1.1 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.1 EPA06661.1 - 0.11 12.1 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 P-loop containing region of AAA domain UvrB PF12344.3 EPA06662.1 - 8.2e-23 79.6 3.7 2.7e-22 77.9 2.6 2.0 1 0 0 1 1 1 1 Ultra-violet resistance protein B Helicase_C PF00271.26 EPA06662.1 - 2.9e-15 55.8 0.0 8e-15 54.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain UVR PF02151.14 EPA06662.1 - 1e-09 37.5 4.5 1e-09 37.5 3.1 2.6 2 0 0 2 2 2 1 UvrB/uvrC motif ResIII PF04851.10 EPA06662.1 - 2.2e-08 34.1 0.0 2.2e-08 34.1 0.0 3.3 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EPA06662.1 - 2.1e-07 30.6 0.2 7.6e-05 22.2 0.1 3.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_19 PF13245.1 EPA06662.1 - 0.00011 21.8 0.2 0.11 12.2 0.0 2.5 2 0 0 2 2 2 2 Part of AAA domain AAA_22 PF13401.1 EPA06662.1 - 0.0029 17.7 1.5 1.3 9.1 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA_30 PF13604.1 EPA06662.1 - 0.011 15.3 0.1 0.47 10.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain Met_synt_B12 PF02965.12 EPA06662.1 - 0.039 13.1 0.6 0.11 11.6 0.1 1.9 2 0 0 2 2 2 0 Vitamin B12 dependent methionine synthase, activation domain UB2H PF14814.1 EPA06662.1 - 0.063 13.0 0.0 0.41 10.4 0.0 2.5 2 1 0 2 2 2 0 Bifunctional transglycosylase second domain AAA_33 PF13671.1 EPA06662.1 - 0.1 12.4 0.1 0.67 9.8 0.0 2.4 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.22 EPA06662.1 - 0.72 10.1 3.8 4.2 7.6 0.0 2.8 3 0 0 3 3 3 0 ABC transporter TPR_11 PF13414.1 EPA06663.1 - 1.4e-06 27.8 0.3 1.5e-06 27.7 0.2 1.1 1 0 0 1 1 1 1 TPR repeat TPR_16 PF13432.1 EPA06663.1 - 2.5e-06 27.9 0.0 2.7e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 EPA06663.1 - 8.1e-06 25.2 1.1 0.0031 17.0 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 EPA06663.1 - 1.1e-05 25.6 0.0 1.4e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 EPA06663.1 - 7.2e-05 22.4 0.1 0.0017 18.1 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 EPA06663.1 - 9.8e-05 22.6 0.1 0.00012 22.3 0.1 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.1 EPA06663.1 - 0.00018 21.7 0.2 0.0046 17.3 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 EPA06663.1 - 0.00057 19.8 2.2 0.0016 18.4 0.2 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 EPA06663.1 - 0.019 15.0 0.0 0.02 15.0 0.0 1.1 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 EPA06663.1 - 0.028 14.1 0.5 0.66 9.8 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat HATPase_c PF02518.21 EPA06665.1 - 7.6e-20 70.6 0.0 2.6e-19 68.9 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF PF01590.21 EPA06665.1 - 8.9e-10 38.8 0.0 1.4e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 GAF domain HisKA PF00512.20 EPA06665.1 - 1e-06 28.6 1.1 1.6e-06 28.0 0.1 1.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF_3 PF13492.1 EPA06665.1 - 2.2e-06 27.8 0.0 5.7e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 GAF domain HATPase_c_5 PF14501.1 EPA06665.1 - 4.1e-05 23.2 0.1 0.00061 19.4 0.0 2.3 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.1 EPA06665.1 - 0.0016 18.1 0.0 0.0044 16.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mitofilin PF09731.4 EPA06665.1 - 0.35 9.4 8.5 0.49 9.0 5.9 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein TFIIB PF00382.14 EPA06666.1 - 2.9e-13 49.4 0.0 6.7e-13 48.2 0.0 1.6 2 0 0 2 2 2 1 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EPA06667.1 - 2.5e-05 23.4 0.6 3.1e-05 23.1 0.4 1.1 1 0 0 1 1 1 1 TFIIB zinc-binding Ribosomal_S27e PF01667.12 EPA06667.1 - 0.018 14.5 0.1 0.021 14.3 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein S27 zf-ribbon_3 PF13248.1 EPA06667.1 - 0.091 11.9 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 zinc-ribbon domain zf-ISL3 PF14690.1 EPA06667.1 - 0.095 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Auto_anti-p27 PF06677.7 EPA06667.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) MAP PF03642.8 EPA06669.1 - 0.0079 16.4 1.3 0.033 14.4 0.9 1.9 1 1 0 1 1 1 1 MAP domain Auxin_BP PF02041.11 EPA06669.1 - 0.01 15.2 0.0 0.012 15.1 0.0 1.1 1 0 0 1 1 1 0 Auxin binding protein Cupin_2 PF07883.6 EPA06669.1 - 0.019 14.4 0.1 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Cupin domain CX PF01705.14 EPA06669.1 - 0.11 12.4 0.1 0.22 11.5 0.1 1.5 1 1 1 2 2 2 0 CX module Hydrolase_like2 PF13246.1 EPA06669.1 - 0.15 12.0 0.1 0.18 11.8 0.1 1.1 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit TPR_11 PF13414.1 EPA06670.1 - 8.3e-33 111.8 15.6 6.5e-10 38.5 0.1 4.0 1 1 4 5 5 5 5 TPR repeat TPR_2 PF07719.12 EPA06670.1 - 1.2e-27 93.4 7.5 0.00015 21.4 0.0 6.1 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.23 EPA06670.1 - 2.5e-26 90.1 14.6 1.9e-06 27.1 0.0 6.1 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.1 EPA06670.1 - 2.7e-21 73.9 5.8 1.6e-05 24.7 0.2 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.1 EPA06670.1 - 2.2e-19 69.1 2.7 1.2e-07 31.5 0.1 3.5 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.1 EPA06670.1 - 4.8e-17 62.1 0.0 9.2e-05 23.0 0.0 4.1 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.1 EPA06670.1 - 5.3e-17 60.2 12.8 0.00029 20.3 0.0 5.7 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.1 EPA06670.1 - 1.2e-16 60.7 1.6 2.9e-05 24.3 0.0 3.7 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_6 PF13174.1 EPA06670.1 - 2.4e-16 58.9 0.1 0.041 14.3 0.0 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 EPA06670.1 - 3.9e-15 54.9 0.0 0.18 12.5 0.0 6.0 1 1 5 6 6 6 5 Tetratricopeptide repeat Apc3 PF12895.2 EPA06670.1 - 1.1e-10 41.4 7.6 1.6e-06 28.1 0.9 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 EPA06670.1 - 1.6e-10 40.6 0.0 0.0012 18.5 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 EPA06670.1 - 9.9e-08 31.2 0.0 0.039 13.7 0.0 5.1 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_10 PF13374.1 EPA06670.1 - 2.6e-06 27.1 0.8 1.7 8.6 0.2 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EPA06670.1 - 4.3e-06 26.4 4.3 0.14 12.0 0.0 5.1 3 1 3 6 6 6 2 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.13 EPA06670.1 - 6.5e-06 25.9 5.5 1.9 8.4 0.1 4.9 4 1 0 4 4 4 2 MIT (microtubule interacting and transport) domain ChAPs PF09295.5 EPA06670.1 - 0.0015 17.4 0.1 0.0025 16.6 0.1 1.3 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) NARP1 PF12569.3 EPA06670.1 - 0.0015 17.3 2.7 0.19 10.4 0.5 2.6 1 1 2 3 3 3 3 NMDA receptor-regulated protein 1 TOM20_plant PF06552.7 EPA06670.1 - 0.0086 15.6 0.5 5.2 6.6 0.0 3.4 1 1 2 3 3 3 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_20 PF14561.1 EPA06670.1 - 0.014 15.5 1.5 0.38 10.8 0.0 3.2 1 1 2 4 4 4 0 Tetratricopeptide repeat PPR PF01535.15 EPA06670.1 - 0.033 14.1 1.0 16 5.7 0.0 3.9 4 0 0 4 4 3 0 PPR repeat PPTA PF01239.17 EPA06670.1 - 0.27 10.6 2.6 6.5 6.2 0.1 3.4 4 1 0 4 4 4 0 Protein prenyltransferase alpha subunit repeat TPPII_N PF12583.3 EPA06670.1 - 0.45 10.6 3.8 1.3 9.1 0.3 2.8 2 1 1 3 3 3 0 Tripeptidyl peptidase II N terminal Arginase PF00491.16 EPA06671.1 - 1.9e-26 93.0 0.0 1.9e-26 92.9 0.0 1.0 1 0 0 1 1 1 1 Arginase family Rhodanese PF00581.15 EPA06673.1 - 1.1e-11 45.0 0.1 1.6e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain UPF0118 PF01594.11 EPA06674.1 - 0.0048 15.9 0.8 0.0054 15.7 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF20 NicO PF03824.11 EPA06674.1 - 0.027 13.7 0.3 0.027 13.7 0.2 1.0 1 0 0 1 1 1 0 High-affinity nickel-transport protein EutH PF04346.7 EPA06674.1 - 0.068 12.1 0.8 0.078 11.9 0.5 1.0 1 0 0 1 1 1 0 Ethanolamine utilisation protein, EutH PrgI PF12666.2 EPA06674.1 - 0.069 13.2 0.4 0.09 12.9 0.3 1.1 1 0 0 1 1 1 0 PrgI family protein DUF4389 PF14333.1 EPA06674.1 - 0.11 12.2 1.2 0.16 11.6 0.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4389) Colicin_V PF02674.11 EPA06674.1 - 0.12 12.2 2.1 0.16 11.8 1.5 1.1 1 0 0 1 1 1 0 Colicin V production protein IncA PF04156.9 EPA06674.1 - 0.13 11.8 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 IncA protein DUF2976 PF11190.3 EPA06674.1 - 5.2 6.6 7.8 2.1 7.9 3.7 1.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2976) Ribosomal_S26e PF01283.14 EPA06675.1 - 7.3e-32 109.9 1.5 8e-32 109.8 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e DUF3279 PF11682.3 EPA06675.1 - 0.036 13.6 2.3 0.52 9.8 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3279) zf-dskA_traR PF01258.12 EPA06675.1 - 0.36 10.6 2.2 1.8 8.3 0.1 2.3 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger TrkH PF02386.11 EPA06676.1 - 1.6e-27 96.0 40.9 5e-26 91.1 21.2 3.3 1 1 0 2 2 2 2 Cation transport protein CBS PF00571.23 EPA06676.1 - 5.3e-18 64.5 4.0 3.8e-09 36.1 0.3 2.5 2 0 0 2 2 2 2 CBS domain 7TMR-DISM_7TM PF07695.6 EPA06677.1 - 2.5 7.7 21.6 4.1 7.0 8.4 2.4 1 1 1 2 2 2 0 7TM diverse intracellular signalling zf-C2H2 PF00096.21 EPA06678.1 - 0.002 18.3 0.6 0.0039 17.4 0.4 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_2 PF12756.2 EPA06678.1 - 0.0029 17.7 1.3 0.0029 17.7 0.9 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.1 EPA06678.1 - 0.0094 16.2 0.2 0.014 15.6 0.1 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger DUF629 PF04780.7 EPA06678.1 - 0.11 11.0 1.4 0.1 11.0 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) zf-C2H2_3 PF13878.1 EPA06678.1 - 0.15 11.6 1.5 0.16 11.5 0.7 1.5 1 1 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO zf-BED PF02892.10 EPA06678.1 - 0.15 11.8 0.9 0.25 11.1 0.6 1.4 1 1 0 1 1 1 0 BED zinc finger zf-met PF12874.2 EPA06678.1 - 0.18 12.0 0.7 0.48 10.7 0.5 1.8 1 1 0 1 1 1 0 Zinc-finger of C2H2 type Arginase PF00491.16 EPA06679.1 - 2.2e-36 125.5 0.0 2.9e-36 125.1 0.0 1.0 1 0 0 1 1 1 1 Arginase family FAD_binding_4 PF01565.18 EPA06679.1 - 0.13 11.7 0.0 3.2 7.2 0.0 2.2 1 1 0 1 1 1 0 FAD binding domain CDP-OH_P_transf PF01066.16 EPA06681.1 - 9.1e-18 64.4 7.5 2.2e-17 63.2 5.2 1.7 1 1 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Class_IIIsignal PF04021.7 EPA06681.1 - 0.042 13.5 3.0 0.042 13.5 2.1 4.5 5 0 0 5 5 5 0 Class III signal peptide tRNA-Thr_ED PF08915.6 EPA06682.1 - 5.2e-49 165.7 0.1 5.9e-49 165.5 0.1 1.0 1 0 0 1 1 1 1 Archaea-specific editing domain of threonyl-tRNA synthetase tRNA-synt_2b PF00587.20 EPA06683.1 - 3.3e-26 91.9 1.0 6.1e-26 91.0 0.7 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EPA06683.1 - 1.9e-24 85.4 0.4 4.2e-24 84.2 0.3 1.6 1 0 0 1 1 1 1 Anticodon binding domain HTH_45 PF14947.1 EPA06684.1 - 4.1e-07 29.7 0.5 6.7e-07 29.0 0.3 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.17 EPA06684.1 - 1.5e-05 24.5 0.0 2.5e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.1 EPA06684.1 - 0.0086 16.0 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain PadR PF03551.9 EPA06684.1 - 0.029 14.1 0.0 0.062 13.0 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family DUF505 PF04458.7 EPA06684.1 - 0.058 11.5 0.1 0.086 10.9 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF505) DUF2513 PF10711.4 EPA06684.1 - 0.12 12.4 0.1 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) CBS PF00571.23 EPA06685.1 - 7e-15 54.5 0.1 5.6e-11 42.0 0.0 2.3 2 0 0 2 2 2 2 CBS domain HTH_3 PF01381.17 EPA06685.1 - 1.3e-13 50.5 0.3 2.4e-13 49.6 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.2 EPA06685.1 - 8.7e-10 38.5 0.2 1.7e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.1 EPA06685.1 - 1.1e-07 31.9 0.0 1.8e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.1 EPA06685.1 - 0.012 15.8 0.1 0.023 14.9 0.1 1.4 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain HTH_25 PF13413.1 EPA06685.1 - 0.024 14.2 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_r4 PF04545.11 EPA06685.1 - 0.066 12.5 0.1 0.13 11.5 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_Crp_2 PF13545.1 EPA06685.1 - 0.093 12.5 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Hemerythrin PF01814.18 EPA06686.1 - 2.9e-13 50.1 1.0 3.8e-13 49.7 0.1 1.6 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain DUF1053 PF06327.9 EPA06686.1 - 0.044 14.1 0.4 0.15 12.4 0.0 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1053) TryThrA_C PF12319.3 EPA06687.1 - 0.0079 15.3 0.8 0.0079 15.3 0.6 1.0 1 0 0 1 1 1 1 Tryptophan-Threonine-rich plasmodium antigen C terminal Glyoxalase_4 PF13669.1 EPA06688.1 - 4.2e-22 78.2 0.0 4.9e-22 78.0 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.20 EPA06688.1 - 8.1e-12 45.2 0.0 8.6e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.1 EPA06688.1 - 2.2e-11 44.0 0.0 2.3e-11 43.9 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.2 EPA06688.1 - 7.1e-07 29.8 0.0 8.4e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain SVM_signal PF12113.3 EPA06689.1 - 0.11 12.3 1.0 0.2 11.5 0.7 1.4 1 0 0 1 1 1 0 SVM protein signal sequence Internalin_N PF12354.3 EPA06689.1 - 0.11 12.0 0.4 0.19 11.3 0.3 1.4 1 0 0 1 1 1 0 Bacterial adhesion/invasion protein N terminal DUF3139 PF11337.3 EPA06689.1 - 0.19 12.0 1.2 0.31 11.3 0.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3139) CTP_transf_2 PF01467.21 EPA06690.1 - 4.7e-14 52.7 0.0 7e-14 52.1 0.0 1.2 1 1 0 1 1 1 1 Cytidylyltransferase Citrate_ly_lig PF08218.6 EPA06690.1 - 0.0011 18.5 0.0 0.043 13.2 0.0 2.2 1 1 0 2 2 2 1 Citrate lyase ligase C-terminal domain HIGH_NTase1 PF05636.6 EPA06690.1 - 0.0022 17.0 0.1 0.016 14.2 0.0 2.0 2 0 0 2 2 2 1 HIGH Nucleotidyl Transferase NTNH_C PF08470.5 EPA06690.1 - 0.019 14.6 0.5 0.033 13.8 0.1 1.6 2 1 0 2 2 2 0 Nontoxic nonhaemagglutinin C-terminal MazG PF03819.12 EPA06690.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain Peptidase_M1 PF01433.15 EPA06691.1 - 2.5e-140 468.0 5.7 3.6e-140 467.4 3.9 1.2 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 EPA06691.1 - 9.9e-58 195.8 0.5 2.1e-57 194.8 0.0 1.8 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 EPA06691.1 - 1.5e-19 70.3 0.1 2.9e-19 69.3 0.1 1.5 1 0 0 1 1 1 1 Peptidase MA superfamily DUF2265 PF10023.4 EPA06691.1 - 0.016 14.3 0.0 0.034 13.3 0.0 1.6 1 0 0 1 1 1 0 Predicted aminopeptidase (DUF2265) DUF3154 PF11351.3 EPA06692.1 - 0.034 13.8 0.0 0.071 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3154) ArgK PF03308.11 EPA06693.1 - 8.3e-69 231.3 3.8 1e-68 231.0 2.6 1.1 1 0 0 1 1 1 1 ArgK protein cobW PF02492.14 EPA06693.1 - 6.1e-07 29.0 0.2 1.3e-06 27.9 0.1 1.6 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.12 EPA06693.1 - 4.8e-06 26.2 0.3 0.0049 16.4 0.1 2.2 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein KAP_NTPase PF07693.9 EPA06693.1 - 0.00023 20.2 0.0 0.00035 19.6 0.0 1.3 1 1 0 1 1 1 1 KAP family P-loop domain DUF258 PF03193.11 EPA06693.1 - 0.0011 18.1 0.3 0.0063 15.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 EPA06693.1 - 0.0033 17.4 0.0 0.0035 17.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain MobB PF03205.9 EPA06693.1 - 0.0065 16.1 0.1 0.074 12.7 0.1 2.3 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 EPA06693.1 - 0.0086 15.5 0.0 0.0096 15.3 0.0 1.3 1 1 0 1 1 1 1 AAA-like domain ABC_tran PF00005.22 EPA06693.1 - 0.0097 16.2 0.1 0.019 15.2 0.1 1.7 1 0 0 1 1 1 1 ABC transporter NB-ARC PF00931.17 EPA06693.1 - 0.011 14.6 0.4 0.027 13.3 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain Arch_ATPase PF01637.13 EPA06693.1 - 0.011 15.4 0.3 0.029 14.0 0.0 1.7 2 0 0 2 2 2 0 Archaeal ATPase AAA_22 PF13401.1 EPA06693.1 - 0.011 15.8 0.1 0.082 13.0 0.1 2.2 1 1 1 2 2 2 0 AAA domain Zeta_toxin PF06414.7 EPA06693.1 - 0.012 14.7 0.6 0.044 12.8 0.1 2.0 2 0 0 2 2 2 0 Zeta toxin AAA_17 PF13207.1 EPA06693.1 - 0.013 16.2 0.3 0.033 15.0 0.2 1.7 1 0 0 1 1 1 0 AAA domain PRK PF00485.13 EPA06693.1 - 0.017 14.7 0.2 0.034 13.7 0.2 1.6 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family MMR_HSR1 PF01926.18 EPA06693.1 - 0.017 15.0 1.5 0.043 13.7 1.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase NTPase_1 PF03266.10 EPA06693.1 - 0.024 14.3 0.2 0.072 12.7 0.2 1.8 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.1 EPA06693.1 - 0.032 13.8 0.3 0.056 13.0 0.2 1.5 1 0 0 1 1 1 0 AAA domain RNA12 PF10443.4 EPA06693.1 - 0.035 12.5 0.0 0.056 11.9 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein AAA_35 PF14516.1 EPA06693.1 - 0.052 12.1 0.0 0.08 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_29 PF13555.1 EPA06693.1 - 0.059 12.9 0.4 0.13 11.8 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Phage_GP20 PF06810.6 EPA06693.1 - 0.064 12.6 0.6 0.11 11.9 0.4 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 AAA_19 PF13245.1 EPA06693.1 - 0.083 12.6 0.3 0.23 11.2 0.2 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_23 PF13476.1 EPA06693.1 - 0.73 10.1 7.2 7.1 6.9 5.0 2.1 1 1 0 1 1 1 0 AAA domain IlvN PF07991.7 EPA06694.1 - 1.9e-66 222.5 0.4 2.6e-66 222.0 0.3 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain IlvC PF01450.14 EPA06694.1 - 1e-48 164.9 0.1 1.5e-48 164.3 0.1 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.10 EPA06694.1 - 3e-06 27.1 0.2 3.5e-05 23.7 0.1 2.4 3 0 0 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 EPA06694.1 - 5.9e-06 25.5 0.1 1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.12 EPA06694.1 - 9.5e-05 22.7 0.1 0.00025 21.3 0.1 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.16 EPA06694.1 - 0.015 15.1 0.2 0.036 13.9 0.1 1.6 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain MM_CoA_mutase PF01642.17 EPA06695.1 - 4.6e-185 615.6 0.1 5.3e-185 615.4 0.0 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase PAP_PilO PF06864.7 EPA06695.1 - 0.0068 14.8 0.0 0.021 13.2 0.0 1.7 2 0 0 2 2 2 1 Pilin accessory protein (PilO) GTP_EFTU_D2 PF03144.20 EPA06696.1 - 8.1e-11 41.8 0.8 1.4e-10 41.1 0.2 1.7 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 EPA06696.1 - 0.02 14.5 1.8 0.041 13.5 0.8 1.8 2 0 0 2 2 2 0 Elongation factor Tu domain 4 DUF4503 PF14951.1 EPA06697.1 - 0.00083 17.6 0.3 0.00085 17.5 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4503) zinc_ribbon_5 PF13719.1 EPA06697.1 - 0.0013 18.3 4.9 0.015 14.8 3.4 2.1 1 1 0 1 1 1 1 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.2 EPA06697.1 - 0.0022 17.7 3.0 0.0029 17.3 2.1 1.2 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA06697.1 - 0.0026 17.4 5.2 0.032 13.9 3.6 2.1 1 1 0 1 1 1 1 zinc-ribbon domain Zn-ribbon_8 PF09723.5 EPA06697.1 - 0.018 15.0 3.1 0.11 12.4 0.5 2.2 2 0 0 2 2 2 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.7 EPA06697.1 - 0.039 13.2 0.8 0.039 13.2 0.6 1.8 2 0 0 2 2 2 0 TFIIB zinc-binding DUF35_N PF12172.3 EPA06697.1 - 0.039 13.8 2.6 0.29 11.1 0.4 2.2 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DNA_ligase_ZBD PF03119.11 EPA06697.1 - 0.1 12.3 0.5 0.1 12.3 0.4 1.9 1 1 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain OrfB_Zn_ribbon PF07282.6 EPA06697.1 - 0.15 11.7 1.5 0.16 11.6 1.0 1.1 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DZR PF12773.2 EPA06697.1 - 0.25 11.1 3.7 0.44 10.4 2.6 1.6 1 1 0 1 1 1 0 Double zinc ribbon zf-IS66 PF13005.2 EPA06697.1 - 0.25 11.3 0.4 0.25 11.3 0.3 2.4 1 1 1 2 2 2 0 zinc-finger binding domain of transposase IS66 zf-MYND PF01753.13 EPA06697.1 - 0.34 10.8 2.1 0.55 10.1 1.4 1.4 1 1 0 1 1 1 0 MYND finger NOB1_Zn_bind PF08772.6 EPA06697.1 - 0.61 9.9 3.1 2.2 8.1 0.2 2.0 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-ribbon_3 PF13248.1 EPA06697.1 - 0.67 9.2 8.0 0.84 8.9 2.7 2.4 2 1 0 2 2 2 0 zinc-ribbon domain Prim_Zn_Ribbon PF08273.7 EPA06697.1 - 0.75 9.9 6.9 1.6 8.8 4.8 1.7 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase TFIIS_C PF01096.13 EPA06697.1 - 0.79 9.4 4.4 8.7 6.0 0.8 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) DUF1451 PF07295.6 EPA06697.1 - 0.79 9.4 3.3 0.26 11.0 0.3 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1451) Lar_restr_allev PF14354.1 EPA06697.1 - 1 9.7 5.1 1.5 9.2 3.6 1.3 1 1 0 1 1 1 0 Restriction alleviation protein Lar Sgf11 PF08209.6 EPA06697.1 - 1 8.7 6.8 2.1 7.7 0.1 2.3 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zf-DNL PF05180.7 EPA06697.1 - 1.6 8.4 5.3 3.5 7.4 3.7 1.6 1 1 0 1 1 1 0 DNL zinc finger zf-ISL3 PF14690.1 EPA06697.1 - 3.2 7.8 8.1 31 4.6 5.8 2.0 1 1 1 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-C2H2 PF00096.21 EPA06697.1 - 9.4 6.8 7.0 3.6 8.1 0.5 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type B12-binding PF02310.14 EPA06698.1 - 1.4e-18 66.8 0.1 1.7e-18 66.5 0.1 1.0 1 0 0 1 1 1 1 B12 binding domain Ocnus PF05005.10 EPA06698.1 - 0.013 15.3 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Janus/Ocnus family (Ocnus) Isochorismatase PF00857.15 EPA06698.1 - 0.039 13.8 0.1 17 5.2 0.1 2.9 1 1 1 3 3 3 0 Isochorismatase family RsmJ PF04378.8 EPA06698.1 - 0.069 12.1 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA small subunit methyltransferase D, RsmJ PcrB PF01884.12 EPA06698.1 - 0.091 11.9 1.5 0.2 10.9 0.1 1.8 1 1 1 2 2 2 0 PcrB family CBS PF00571.23 EPA06699.1 - 7.8e-18 63.9 0.2 1.1e-10 41.1 0.0 2.4 2 0 0 2 2 2 2 CBS domain DUF556 PF04476.8 EPA06699.1 - 0.078 12.1 0.7 0.093 11.9 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF556) AAA PF00004.24 EPA06700.1 - 2.4e-64 215.4 0.0 9.2e-48 161.7 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EPA06700.1 - 1.8e-06 28.0 0.2 9.4e-05 22.4 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.9 EPA06700.1 - 3e-06 27.2 0.0 8e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 EPA06700.1 - 3.9e-05 23.8 0.0 0.0009 19.3 0.0 2.3 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.8 EPA06700.1 - 4.9e-05 22.2 0.2 0.00029 19.6 0.0 2.0 2 0 0 2 2 2 1 TIP49 C-terminus AAA_5 PF07728.9 EPA06700.1 - 7.2e-05 22.5 0.2 0.0024 17.6 0.1 3.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 EPA06700.1 - 0.00025 20.9 0.0 0.0006 19.7 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.1 EPA06700.1 - 0.00073 20.3 0.3 0.0046 17.7 0.0 2.4 2 1 0 3 3 2 1 AAA domain IstB_IS21 PF01695.12 EPA06700.1 - 0.0015 17.9 0.0 0.0029 17.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.7 EPA06700.1 - 0.0016 17.5 0.0 0.0049 15.9 0.0 1.9 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Arch_ATPase PF01637.13 EPA06700.1 - 0.0018 18.0 0.0 1 8.9 0.0 3.2 2 2 1 3 3 3 1 Archaeal ATPase AAA_14 PF13173.1 EPA06700.1 - 0.0029 17.5 0.0 0.009 15.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.21 EPA06700.1 - 0.0029 17.0 0.0 0.017 14.5 0.0 2.1 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_19 PF13245.1 EPA06700.1 - 0.0081 15.9 2.1 0.039 13.7 0.1 2.7 3 0 0 3 3 2 1 Part of AAA domain Zeta_toxin PF06414.7 EPA06700.1 - 0.0096 15.0 0.1 0.078 12.0 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.7 EPA06700.1 - 0.01 15.5 0.1 0.25 10.9 0.1 2.3 1 1 1 2 2 2 0 NACHT domain AAA_25 PF13481.1 EPA06700.1 - 0.011 15.1 0.8 2.1 7.7 0.2 2.7 1 1 0 2 2 2 0 AAA domain PhoH PF02562.11 EPA06700.1 - 0.018 14.2 0.1 0.038 13.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_18 PF13238.1 EPA06700.1 - 0.047 13.9 1.1 0.27 11.5 0.0 2.6 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.17 EPA06700.1 - 0.056 13.6 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Sigma54_activ_2 PF14532.1 EPA06700.1 - 0.067 13.2 0.0 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_28 PF13521.1 EPA06700.1 - 0.083 12.8 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Bac_DnaA PF00308.13 EPA06700.1 - 0.085 12.4 0.1 1.5 8.3 0.0 2.6 3 0 0 3 3 3 0 Bacterial dnaA protein Mg_chelatase PF01078.16 EPA06700.1 - 0.087 11.9 0.5 0.2 10.7 0.1 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_10 PF12846.2 EPA06700.1 - 0.1 12.0 0.2 0.39 10.1 0.2 2.0 1 1 0 1 1 1 0 AAA-like domain KaiC PF06745.8 EPA06700.1 - 0.11 11.6 0.4 0.51 9.4 0.0 2.3 3 0 0 3 3 3 0 KaiC ABC_tran PF00005.22 EPA06700.1 - 0.13 12.5 0.0 0.36 11.1 0.0 1.8 1 0 0 1 1 1 0 ABC transporter A2M_N PF01835.14 EPA06702.1 - 2.5e-05 24.4 0.1 4.3e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 MG2 domain Big_2 PF02368.13 EPA06702.1 - 0.61 10.0 5.3 0.21 11.4 0.9 2.4 2 1 0 2 2 2 0 Bacterial Ig-like domain (group 2) RNA_pol_Rpb2_6 PF00562.23 EPA06703.1 - 2.9e-121 404.8 0.0 4.6e-121 404.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 EPA06703.1 - 4.6e-56 188.9 0.0 6.8e-56 188.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.15 EPA06703.1 - 1.1e-29 102.4 0.0 2.4e-29 101.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.11 EPA06703.1 - 7.9e-27 92.8 0.1 1.9e-26 91.5 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.9 EPA06703.1 - 1.2e-23 83.5 0.0 2.8e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.8 EPA06703.1 - 1e-13 50.8 0.1 3.2e-13 49.2 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.12 EPA06703.1 - 5e-12 45.5 0.5 1.1e-11 44.5 0.3 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Zn_Tnp_IS1595 PF12760.2 EPA06703.1 - 0.054 13.3 0.2 0.12 12.1 0.1 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Ribosomal_L37e PF01907.14 EPA06703.1 - 0.19 11.5 0.7 0.47 10.2 0.5 1.6 1 0 0 1 1 1 0 Ribosomal protein L37e OrfB_Zn_ribbon PF07282.6 EPA06703.1 - 0.31 10.7 1.6 0.75 9.4 0.6 2.0 2 0 0 2 2 2 0 Putative transposase DNA-binding domain A2M_N PF01835.14 EPA06704.1 - 1.5e-05 25.1 0.6 0.02 15.1 0.1 2.5 2 1 0 2 2 2 2 MG2 domain P_proprotein PF01483.15 EPA06704.1 - 0.00043 20.0 0.1 0.011 15.5 0.0 2.7 2 1 1 3 3 3 1 Proprotein convertase P-domain FixH PF05751.6 EPA06704.1 - 0.059 13.1 3.5 2.2 8.0 0.0 3.0 2 1 1 3 3 3 0 FixH PsbH PF00737.15 EPA06704.1 - 0.064 12.8 0.5 0.15 11.6 0.4 1.6 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein Cna_B PF05738.8 EPA06704.1 - 0.18 11.5 1.2 0.49 10.2 0.2 2.2 2 1 1 3 3 3 0 Cna protein B-type domain A2M_N PF01835.14 EPA06705.1 - 0.0049 17.0 0.2 0.54 10.5 0.0 2.8 3 0 0 3 3 3 1 MG2 domain DUF1425 PF07233.7 EPA06705.1 - 0.033 13.7 1.1 0.51 9.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1425) CARDB PF07705.6 EPA06705.1 - 0.081 12.9 0.5 0.27 11.3 0.4 1.8 1 0 0 1 1 1 0 CARDB LSM PF01423.17 EPA06706.1 - 2.6e-17 62.1 1.3 3.1e-17 61.8 0.9 1.1 1 0 0 1 1 1 1 LSM domain DUF4493 PF14900.1 EPA06707.1 - 0.0021 17.7 1.1 0.06 12.9 0.1 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4493) A2M_N PF01835.14 EPA06707.1 - 0.009 16.2 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 1 MG2 domain DUF4369 PF14289.1 EPA06707.1 - 0.029 14.3 0.1 0.042 13.8 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4369) DUF3992 PF13157.1 EPA06707.1 - 0.43 10.8 6.3 0.43 10.8 1.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3992) A2M_N PF01835.14 EPA06708.1 - 4.8e-05 23.5 0.0 9.7e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 MG2 domain DUF4493 PF14900.1 EPA06708.1 - 0.031 13.9 3.8 0.15 11.6 0.0 2.9 2 2 1 3 3 3 0 Domain of unknown function (DUF4493) RNA_pol_Rpb1_5 PF04998.12 EPA06709.1 - 3.2e-85 285.7 1.9 6.5e-85 284.7 1.3 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.7 EPA06709.1 - 2.9e-83 279.9 0.6 1.7e-81 274.1 0.1 2.9 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.15 EPA06709.1 - 4.1e-70 235.0 0.0 8.6e-70 233.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 EPA06709.1 - 4.1e-35 120.8 0.0 1.2e-34 119.3 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 EPA06709.1 - 7.3e-24 83.5 0.2 1.2e-22 79.6 0.0 2.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 Peptidase_C34 PF05413.6 EPA06709.1 - 0.062 13.3 0.0 11 6.1 0.0 2.8 2 0 0 2 2 2 0 Putative closterovirus papain-like endopeptidase TniQ PF06527.6 EPA06709.1 - 0.072 13.2 0.0 10 6.3 0.0 2.5 2 0 0 2 2 2 0 TniQ UPF0547 PF10571.4 EPA06709.1 - 0.12 12.0 0.1 0.27 10.9 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 RNA_pol_Rpb5_C PF01191.14 EPA06710.1 - 5.8e-29 99.4 0.1 6.8e-29 99.2 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain PD40 PF07676.7 EPA06711.1 - 2.5e-19 68.5 13.0 0.00016 21.2 0.1 5.0 5 0 0 5 5 5 4 WD40-like Beta Propeller Repeat DPPIV_N PF00930.16 EPA06711.1 - 6.7e-06 24.9 0.7 0.037 12.6 0.1 3.2 1 1 2 3 3 3 3 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pectate_lyase22 PF14583.1 EPA06711.1 - 0.0012 17.3 0.1 0.082 11.3 0.0 2.3 1 1 0 2 2 2 2 Oligogalacturonate lyase Lactonase PF10282.4 EPA06712.1 - 9.8e-10 38.0 4.7 0.002 17.2 0.0 4.1 1 1 4 5 5 5 4 Lactonase, 7-bladed beta-propeller NHL PF01436.16 EPA06712.1 - 2.1e-06 27.3 14.4 0.02 14.8 0.3 5.0 6 0 0 6 6 6 3 NHL repeat Cytochrom_D1 PF02239.11 EPA06712.1 - 2.6e-06 26.0 0.9 0.0038 15.5 0.1 2.7 1 1 0 2 2 2 2 Cytochrome D1 heme domain Arylesterase PF01731.15 EPA06712.1 - 1.1e-05 25.2 14.6 0.92 9.5 0.1 6.1 3 2 3 6 6 6 3 Arylesterase PD40 PF07676.7 EPA06712.1 - 0.0002 20.9 0.3 0.0006 19.4 0.2 1.9 1 0 0 1 1 1 1 WD40-like Beta Propeller Repeat SGL PF08450.7 EPA06712.1 - 0.0048 16.3 2.7 0.21 10.9 0.0 3.3 2 2 1 3 3 3 1 SMP-30/Gluconolaconase/LRE-like region DUF4221 PF13970.1 EPA06712.1 - 0.006 15.9 5.5 0.54 9.5 0.2 3.5 2 2 1 3 3 3 2 Domain of unknown function (DUF4221) Usher PF00577.15 EPA06713.1 - 0.00041 19.2 0.0 0.00058 18.7 0.0 1.1 1 0 0 1 1 1 1 Outer membrane usher protein Lumazine_bd PF12870.2 EPA06713.1 - 0.017 15.2 0.3 0.04 13.9 0.1 1.6 2 0 0 2 2 2 0 Lumazine-binding domain LEA_2 PF03168.8 EPA06713.1 - 0.053 13.8 0.0 0.079 13.3 0.0 1.4 1 0 0 1 1 1 0 Late embryogenesis abundant protein DUF3426 PF11906.3 EPA06713.1 - 0.061 12.9 0.1 0.13 11.8 0.0 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3426) Cas_Cas4 PF01930.12 EPA06714.1 - 1.6e-05 24.8 0.4 2.7e-05 24.1 0.2 1.6 1 1 0 1 1 1 1 Domain of unknown function DUF83 DDE_Tnp_1_6 PF13751.1 EPA06714.1 - 0.055 13.4 0.5 0.12 12.3 0.3 1.5 1 0 0 1 1 1 0 Transposase DDE domain PDDEXK_1 PF12705.2 EPA06714.1 - 0.21 10.9 2.9 2.4 7.4 2.0 2.1 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily IncA PF04156.9 EPA06715.1 - 0.054 13.0 0.0 2.1 7.8 0.0 2.4 2 1 0 2 2 2 0 IncA protein AA_kinase PF00696.23 EPA06716.1 - 2e-28 99.5 0.1 8.2e-28 97.5 0.0 1.9 2 1 0 2 2 2 1 Amino acid kinase family ACT PF01842.20 EPA06716.1 - 2.6e-22 77.8 1.2 1.1e-10 40.7 0.1 2.3 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.1 EPA06716.1 - 7.7e-20 70.1 4.9 1.3e-12 46.9 0.2 2.4 2 0 0 2 2 2 2 ACT domain ACT_6 PF13740.1 EPA06716.1 - 0.0073 16.0 2.2 0.25 11.0 0.0 3.1 3 0 0 3 3 3 1 ACT domain Thiolase_C PF02803.13 EPA06717.1 - 6e-12 45.0 1.3 3.5e-10 39.3 0.0 2.9 2 2 2 4 4 4 1 Thiolase, C-terminal domain Thiolase_N PF00108.18 EPA06717.1 - 5.5e-08 32.1 0.0 3.8e-07 29.3 0.0 2.3 3 0 0 3 3 3 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.21 EPA06717.1 - 0.00021 20.8 0.2 0.054 12.9 0.1 2.6 3 0 0 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 EPA06717.1 - 0.029 14.2 0.5 2.2 8.1 0.0 3.1 3 0 0 3 3 3 0 Beta-ketoacyl synthase, C-terminal domain Methyltransf_31 PF13847.1 EPA06718.1 - 1.4e-14 53.9 0.4 1.6e-14 53.7 0.2 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EPA06718.1 - 1.7e-11 43.6 0.0 1.8e-11 43.5 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EPA06718.1 - 1.1e-09 38.5 0.1 1.6e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EPA06718.1 - 1.3e-09 38.6 0.0 1.6e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA06718.1 - 4.8e-09 36.5 0.0 6.1e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EPA06718.1 - 1e-06 28.2 0.1 1.3e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 EPA06718.1 - 2.9e-06 27.6 0.0 3.9e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EPA06718.1 - 6.3e-06 25.9 0.0 7.4e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EPA06718.1 - 9.9e-05 21.9 0.0 0.00011 21.7 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.15 EPA06718.1 - 0.00012 21.1 0.0 0.00013 21.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PrmA PF06325.8 EPA06718.1 - 0.00045 19.4 0.2 0.00056 19.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 EPA06718.1 - 0.00071 19.6 0.0 0.00094 19.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 EPA06718.1 - 0.0023 17.3 0.0 0.0028 17.0 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) MetW PF07021.7 EPA06718.1 - 0.0034 16.8 0.0 0.0041 16.5 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW FtsJ PF01728.14 EPA06718.1 - 0.0066 16.4 0.0 0.0078 16.2 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase CMAS PF02353.15 EPA06718.1 - 0.031 13.3 0.0 0.031 13.3 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase UPF0020 PF01170.13 EPA06718.1 - 0.1 12.1 0.1 0.38 10.3 0.1 1.8 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 DREV PF05219.7 EPA06718.1 - 0.1 11.4 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 DREV methyltransferase Fibrillarin PF01269.12 EPA06718.1 - 0.11 11.4 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Fibrillarin Pox_MCEL PF03291.11 EPA06718.1 - 0.25 10.1 5.2 2.5 6.8 3.6 2.0 1 1 0 1 1 1 0 mRNA capping enzyme CheR PF01739.13 EPA06718.1 - 1.1 8.5 3.5 1.8 7.7 0.6 2.1 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain zf-C4_Topoisom PF01396.14 EPA06719.1 - 9.3e-08 31.4 7.8 2.5e-06 26.8 0.6 2.7 2 0 0 2 2 2 2 Topoisomerase DNA binding C4 zinc finger Ogr_Delta PF04606.7 EPA06719.1 - 0.011 15.4 9.7 0.38 10.4 1.2 3.2 2 2 0 2 2 2 0 Ogr/Delta-like zinc finger Zn_ribbon_recom PF13408.1 EPA06719.1 - 0.091 13.0 8.3 0.88 9.8 0.6 2.4 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain zf-ribbon_3 PF13248.1 EPA06721.1 - 0.0002 20.4 1.8 0.053 12.7 0.2 2.1 2 0 0 2 2 2 2 zinc-ribbon domain zinc_ribbon_2 PF13240.1 EPA06721.1 - 0.00021 20.6 3.0 0.043 13.3 0.2 2.2 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.2 EPA06721.1 - 0.0014 18.3 1.2 0.0026 17.5 0.9 1.4 1 1 0 1 1 1 1 Double zinc ribbon TF_Zn_Ribbon PF08271.7 EPA06721.1 - 0.002 17.3 0.5 0.35 10.2 0.1 2.1 2 0 0 2 2 2 1 TFIIB zinc-binding Chordopox_RPO7 PF05864.7 EPA06721.1 - 0.0023 17.9 1.1 0.078 13.0 0.3 2.1 1 1 1 2 2 2 2 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) zf-C4_Topoisom PF01396.14 EPA06721.1 - 0.0032 16.9 3.4 0.12 11.8 0.2 2.2 2 0 0 2 2 2 1 Topoisomerase DNA binding C4 zinc finger zf-LITAF-like PF10601.4 EPA06721.1 - 0.0045 16.8 1.4 0.29 11.0 0.1 2.2 1 1 1 2 2 2 1 LITAF-like zinc ribbon domain FANCL_C PF11793.3 EPA06721.1 - 0.0086 16.0 1.2 0.032 14.1 0.8 1.8 1 1 0 1 1 1 1 FANCL C-terminal domain zf-DNA_Pol PF08996.5 EPA06721.1 - 0.01 15.2 0.6 0.01 15.2 0.4 1.0 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger zf-IS66 PF13005.2 EPA06721.1 - 0.012 15.6 0.5 0.52 10.3 0.0 2.1 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 Prok-RING_1 PF14446.1 EPA06721.1 - 0.012 15.3 0.8 0.53 10.0 0.0 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-C3HC4_3 PF13920.1 EPA06721.1 - 0.022 14.4 1.7 0.036 13.7 1.2 1.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Sgf11 PF08209.6 EPA06721.1 - 0.023 14.0 0.6 2.5 7.4 0.0 2.1 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zinc_ribbon_5 PF13719.1 EPA06721.1 - 0.024 14.1 2.5 1.1 8.8 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain LIM PF00412.17 EPA06721.1 - 0.026 14.5 0.1 0.048 13.7 0.1 1.4 1 1 0 1 1 1 0 LIM domain zf-C2HC5 PF06221.8 EPA06721.1 - 0.027 14.2 1.8 0.4 10.4 1.3 2.0 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type zinc_ribbon_4 PF13717.1 EPA06721.1 - 0.027 14.1 2.3 1.4 8.6 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-TFIIB PF13453.1 EPA06721.1 - 0.031 13.4 0.8 0.12 11.6 0.0 2.0 2 0 0 2 2 2 0 Transcription factor zinc-finger zf-C2H2 PF00096.21 EPA06721.1 - 0.033 14.5 1.6 6.3 7.3 0.0 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type Lar_restr_allev PF14354.1 EPA06721.1 - 0.041 14.1 0.4 0.067 13.4 0.3 1.4 1 1 0 1 1 1 0 Restriction alleviation protein Lar DUF4428 PF14471.1 EPA06721.1 - 0.042 13.5 3.7 2.7 7.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) zf-dskA_traR PF01258.12 EPA06721.1 - 0.044 13.5 0.7 2.9 7.7 0.0 2.1 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger zf-ISL3 PF14690.1 EPA06721.1 - 0.047 13.7 0.9 5.5 7.1 0.1 2.1 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-Di19 PF05605.7 EPA06721.1 - 0.057 13.5 0.2 0.19 11.9 0.2 1.8 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding HypA PF01155.14 EPA06721.1 - 0.067 12.8 0.4 0.097 12.3 0.3 1.4 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family YhfH PF14149.1 EPA06721.1 - 0.069 12.9 5.1 2.9 7.7 0.7 2.2 2 0 0 2 2 2 0 YhfH-like protein TFIIS_C PF01096.13 EPA06721.1 - 0.071 12.7 1.8 5.4 6.7 0.0 2.1 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) DNA_RNApol_7kD PF03604.8 EPA06721.1 - 0.072 12.5 1.3 2.2 7.8 0.1 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Elf1 PF05129.8 EPA06721.1 - 0.08 12.6 1.4 2.4 7.9 0.1 1.8 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like Zn_Tnp_IS1 PF03811.8 EPA06721.1 - 0.084 12.3 0.9 6.3 6.3 0.1 2.1 2 0 0 2 2 2 0 InsA N-terminal domain Ogr_Delta PF04606.7 EPA06721.1 - 0.1 12.2 0.7 2.5 7.8 0.1 2.1 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger zf-H2C2_2 PF13465.1 EPA06721.1 - 0.11 12.8 0.8 2.1 8.7 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger double domain Stc1 PF12898.2 EPA06721.1 - 0.11 12.5 0.3 0.13 12.3 0.2 1.2 1 0 0 1 1 1 0 Stc1 domain Zn-ribbon_8 PF09723.5 EPA06721.1 - 0.11 12.4 3.9 0.87 9.5 2.7 2.0 1 1 0 1 1 1 0 Zinc ribbon domain Rad50_zn_hook PF04423.9 EPA06721.1 - 0.12 11.8 0.5 0.18 11.2 0.3 1.5 1 1 0 1 1 1 0 Rad50 zinc hook motif Nudix_N_2 PF14803.1 EPA06721.1 - 0.12 12.0 0.9 3.4 7.4 0.1 2.1 2 0 0 2 2 2 0 Nudix N-terminal DUF329 PF03884.9 EPA06721.1 - 0.13 11.8 0.5 2 8.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF329) UPF0547 PF10571.4 EPA06721.1 - 0.14 11.8 1.1 0.76 9.5 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 DNA_ligase_ZBD PF03119.11 EPA06721.1 - 0.15 11.8 2.1 0.16 11.6 0.3 1.9 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain DiS_P_DiS PF06750.8 EPA06721.1 - 0.16 11.8 1.0 0.78 9.5 0.7 1.8 1 1 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain Zn_ribbon_recom PF13408.1 EPA06721.1 - 0.16 12.2 1.1 5.9 7.2 0.1 2.1 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Zn_Tnp_IS1595 PF12760.2 EPA06721.1 - 0.19 11.5 2.1 1.6 8.5 0.0 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain Mu-like_Com PF10122.4 EPA06721.1 - 0.2 10.7 2.0 0.74 8.9 1.4 1.8 1 1 0 1 1 1 0 Mu-like prophage protein Com zinc-ribbons_6 PF07191.7 EPA06721.1 - 0.22 11.3 1.4 5.2 6.9 0.1 2.1 1 1 0 2 2 2 0 zinc-ribbons zf-NADH-PPase PF09297.6 EPA06721.1 - 0.25 10.8 4.4 4.3 6.9 0.2 2.1 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain T4_baseplate PF12322.3 EPA06721.1 - 0.35 10.1 1.7 3.1 6.9 0.1 2.0 1 1 1 2 2 2 0 T4 bacteriophage base plate protein ADK_lid PF05191.9 EPA06721.1 - 0.98 9.1 5.5 17 5.1 3.6 2.1 1 1 0 1 1 1 0 Adenylate kinase, active site lid OrfB_Zn_ribbon PF07282.6 EPA06721.1 - 1.1 8.9 3.5 5.3 6.7 0.1 2.0 1 1 1 2 2 2 0 Putative transposase DNA-binding domain DUF1610 PF07754.6 EPA06721.1 - 1.4 9.0 4.6 12 6.1 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) DUF3797 PF12677.2 EPA06721.1 - 1.8 8.2 5.1 0.63 9.7 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) Cript PF10235.4 EPA06721.1 - 2 8.8 4.7 41 4.6 0.6 2.0 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT DUF137 PF02006.11 EPA06722.1 - 1.7e-20 73.1 0.2 2.2e-20 72.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF137 TPP_enzyme_M PF00205.17 EPA06722.1 - 0.044 13.5 0.5 0.07 12.8 0.4 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain Lumazine_bd PF12870.2 EPA06722.1 - 0.11 12.5 1.2 0.19 11.8 0.8 1.3 1 1 0 1 1 1 0 Lumazine-binding domain Aminotran_5 PF00266.14 EPA06723.1 - 1.5e-37 129.2 0.0 1.9e-37 128.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EPA06723.1 - 3.2e-05 22.3 0.7 4.7e-05 21.8 0.5 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 EPA06723.1 - 0.0048 16.0 0.0 0.015 14.4 0.0 1.6 2 0 0 2 2 2 1 Beta-eliminating lyase Lipoprotein_9 PF03180.9 EPA06723.1 - 0.02 13.7 0.0 0.032 13.1 0.0 1.2 1 0 0 1 1 1 0 NLPA lipoprotein HD PF01966.17 EPA06724.1 - 6.9e-17 61.5 0.2 1.5e-16 60.5 0.1 1.6 1 0 0 1 1 1 1 HD domain HDOD PF08668.7 EPA06724.1 - 0.036 13.3 0.0 0.066 12.4 0.0 1.4 1 0 0 1 1 1 0 HDOD domain Glyco_trans_1_2 PF13524.1 EPA06725.1 - 0.062 13.5 0.0 0.089 13.0 0.0 1.4 1 1 0 1 1 1 0 Glycosyl transferases group 1 DUF35 PF01796.12 EPA06727.1 - 2.7e-08 33.8 0.2 3.8e-08 33.4 0.1 1.2 1 0 0 1 1 1 1 DUF35 OB-fold domain zinc_ribbon_2 PF13240.1 EPA06727.1 - 0.00014 21.2 4.0 0.00025 20.4 2.8 1.4 1 0 0 1 1 1 1 zinc-ribbon domain DUF35_N PF12172.3 EPA06727.1 - 0.00016 21.4 0.1 0.00025 20.8 0.0 1.3 1 0 0 1 1 1 1 Rubredoxin-like zinc ribbon domain (DUF35_N) DZR PF12773.2 EPA06727.1 - 0.015 15.0 0.3 0.026 14.3 0.2 1.3 1 0 0 1 1 1 0 Double zinc ribbon PHF5 PF03660.9 EPA06727.1 - 0.049 13.6 0.2 0.073 13.1 0.2 1.3 1 0 0 1 1 1 0 PHF5-like protein TFIIS_C PF01096.13 EPA06727.1 - 0.063 12.9 2.6 3 7.5 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) DUF2072 PF09845.4 EPA06727.1 - 0.12 12.3 1.4 0.16 11.9 0.9 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) zf-ribbon_3 PF13248.1 EPA06727.1 - 0.17 11.1 2.1 0.39 9.9 1.5 1.7 1 1 0 1 1 1 0 zinc-ribbon domain CpXC PF14353.1 EPA06727.1 - 0.36 10.7 1.7 0.48 10.3 0.4 1.7 1 1 1 2 2 2 0 CpXC protein PfkB PF00294.19 EPA06728.1 - 2.3e-23 82.7 0.2 6.7e-23 81.2 0.1 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 EPA06728.1 - 4e-06 26.2 0.0 7.4e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Carb_kinase PF01256.12 EPA06728.1 - 0.0016 17.7 0.3 0.68 9.1 0.1 2.6 2 1 1 3 3 3 2 Carbohydrate kinase MacB_PCD PF12704.2 EPA06729.1 - 5.9e-27 94.7 2.1 1.2e-26 93.7 1.5 1.4 1 0 0 1 1 1 1 MacB-like periplasmic core domain FtsX PF02687.16 EPA06729.1 - 7.8e-19 67.6 7.5 7.8e-19 67.6 5.2 1.9 2 0 0 2 2 2 1 FtsX-like permease family DUF4231 PF14015.1 EPA06729.1 - 0.085 12.8 1.2 1.6 8.7 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) NikR_C PF08753.6 EPA06730.1 - 1.1e-10 41.2 2.3 1.7e-10 40.6 1.6 1.3 1 0 0 1 1 1 1 NikR C terminal nickel binding domain RHH_1 PF01402.16 EPA06730.1 - 4.6e-05 23.1 0.1 7e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family DUF2191 PF09957.4 EPA06730.1 - 0.0032 17.2 0.0 0.0055 16.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2191) DUF1327 PF07041.6 EPA06730.1 - 0.094 12.6 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1327) FeoC PF09012.5 EPA06731.1 - 9.4e-05 22.0 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 FeoC like transcriptional regulator HTH_45 PF14947.1 EPA06731.1 - 0.018 14.8 0.9 0.018 14.8 0.7 2.0 1 1 0 2 2 2 0 Winged helix-turn-helix CtsR PF05848.6 EPA06731.1 - 0.031 14.2 0.5 0.039 13.9 0.4 1.2 1 0 0 1 1 1 0 Firmicute transcriptional repressor of class III stress genes (CtsR) MarR PF01047.17 EPA06731.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 MarR family DUF3888 PF13027.1 EPA06732.1 - 0.2 11.5 3.0 0.35 10.7 2.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3888) CN_hydrolase PF00795.17 EPA06735.1 - 6.3e-28 97.3 0.0 9e-28 96.8 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase zf-C2H2_4 PF13894.1 EPA06736.1 - 2e-07 30.8 3.7 0.0045 17.2 0.4 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EPA06736.1 - 2.7e-06 27.3 6.8 0.0083 16.4 0.2 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type TF_Zn_Ribbon PF08271.7 EPA06736.1 - 0.00068 18.8 0.5 0.12 11.6 0.0 2.2 2 0 0 2 2 2 1 TFIIB zinc-binding zf-ribbon_3 PF13248.1 EPA06736.1 - 0.0025 16.9 0.4 0.59 9.4 0.0 2.2 2 0 0 2 2 2 1 zinc-ribbon domain zf-C2H2_6 PF13912.1 EPA06736.1 - 0.0063 16.3 2.0 0.0063 16.3 1.4 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger PHF5 PF03660.9 EPA06736.1 - 0.012 15.7 1.9 0.012 15.6 1.3 1.1 1 0 0 1 1 1 0 PHF5-like protein zf-FPG_IleRS PF06827.9 EPA06736.1 - 0.013 15.0 2.1 0.39 10.4 0.2 2.2 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Rubredoxin PF00301.15 EPA06736.1 - 0.017 14.9 0.6 2 8.3 0.1 2.1 2 0 0 2 2 2 0 Rubredoxin DZR PF12773.2 EPA06736.1 - 0.018 14.8 4.2 0.018 14.8 2.9 1.5 1 1 0 1 1 1 0 Double zinc ribbon RNA_POL_M_15KD PF02150.11 EPA06736.1 - 0.023 14.3 4.7 0.47 10.1 3.3 2.2 1 1 1 2 2 2 0 RNA polymerases M/15 Kd subunit Prok-RING_1 PF14446.1 EPA06736.1 - 0.028 14.1 6.3 0.78 9.5 1.2 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zinc_ribbon_5 PF13719.1 EPA06736.1 - 0.039 13.5 4.5 1.9 8.1 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA06736.1 - 0.043 13.5 4.2 1.7 8.3 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF678 PF05077.7 EPA06736.1 - 0.046 13.7 3.3 1.3 9.0 2.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF678) zinc_ribbon_2 PF13240.1 EPA06736.1 - 0.046 13.2 1.6 2.1 7.9 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Ribosomal_L37e PF01907.14 EPA06736.1 - 0.055 13.2 5.3 1.2 9.0 0.9 2.3 2 0 0 2 2 2 0 Ribosomal protein L37e ADK_lid PF05191.9 EPA06736.1 - 0.06 13.0 2.9 3.7 7.2 0.1 2.2 2 0 0 2 2 2 0 Adenylate kinase, active site lid DUF1610 PF07754.6 EPA06736.1 - 0.077 13.1 1.1 0.21 11.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) Ribosomal_S27e PF01667.12 EPA06736.1 - 0.11 12.0 3.8 0.15 11.6 0.3 2.1 1 1 1 2 2 2 0 Ribosomal protein S27 FYVE PF01363.16 EPA06736.1 - 0.12 12.2 7.4 0.36 10.7 1.4 2.0 1 1 1 2 2 2 0 FYVE zinc finger Zn-ribbon_8 PF09723.5 EPA06736.1 - 0.13 12.2 7.9 1.8 8.6 3.5 2.3 1 1 1 2 2 2 0 Zinc ribbon domain XPA_N PF01286.13 EPA06736.1 - 0.13 11.9 3.5 2.3 7.9 0.4 2.2 2 0 0 2 2 2 0 XPA protein N-terminal zf-C2H2_2 PF12756.2 EPA06736.1 - 0.23 11.5 6.6 1.1 9.3 1.1 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) GCC2_GCC3 PF07699.8 EPA06736.1 - 0.25 10.9 10.1 0.1 12.1 2.0 2.1 1 1 1 2 2 2 0 GCC2 and GCC3 GFA PF04828.9 EPA06736.1 - 0.28 11.1 3.9 0.95 9.4 0.2 2.0 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme C1_1 PF00130.17 EPA06736.1 - 0.29 10.8 6.4 1.7 8.4 1.1 2.1 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Rpr2 PF04032.11 EPA06736.1 - 0.35 10.7 5.3 1.1 9.2 3.7 1.8 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain A2L_zn_ribbon PF08792.5 EPA06736.1 - 0.48 9.9 2.7 7.8 6.0 0.2 2.3 2 0 0 2 2 2 0 A2L zinc ribbon domain PyrI_C PF02748.10 EPA06736.1 - 0.49 9.8 4.7 1.6 8.2 0.3 2.0 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Med27 PF11571.3 EPA06736.1 - 0.59 10.2 4.8 1.2 9.2 0.4 2.1 1 1 1 2 2 2 0 Mediator complex subunit 27 Synaptonemal_3 PF15191.1 EPA06736.1 - 0.76 9.5 4.1 1.2 8.8 0.5 2.0 1 1 1 2 2 2 0 Synaptonemal complex central element protein 3 Fer4 PF00037.22 EPA06736.1 - 0.84 9.3 4.7 10 5.9 0.3 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Rad50_zn_hook PF04423.9 EPA06736.1 - 1.1 8.7 7.5 4.1 6.9 1.7 2.2 1 1 1 2 2 2 0 Rad50 zinc hook motif HypA PF01155.14 EPA06736.1 - 1.5 8.5 6.6 2.5 7.8 3.2 1.9 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-H2C2_2 PF13465.1 EPA06736.1 - 1.7 9.0 10.0 1.9 8.9 1.3 3.0 3 0 0 3 3 3 0 Zinc-finger double domain Auto_anti-p27 PF06677.7 EPA06736.1 - 2.1 8.1 5.0 0.93 9.3 0.2 2.2 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-C2H2_3 PF13878.1 EPA06736.1 - 2.3 7.8 10.2 5.5 6.6 1.0 2.5 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO YhfH PF14149.1 EPA06736.1 - 2.4 8.0 9.6 9.4 6.1 0.1 2.4 2 1 0 2 2 2 0 YhfH-like protein DUF3795 PF12675.2 EPA06736.1 - 3.4 7.9 9.5 4.1 7.6 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3795) OrfB_Zn_ribbon PF07282.6 EPA06736.1 - 3.4 7.3 7.2 7.9 6.2 4.3 1.8 1 1 0 1 1 1 0 Putative transposase DNA-binding domain DM PF00751.13 EPA06736.1 - 4.2 6.9 11.6 0.88 9.1 2.3 2.3 2 1 0 2 2 2 0 DM DNA binding domain zf-BED PF02892.10 EPA06736.1 - 4.6 7.0 10.2 2.1 8.2 0.7 2.4 1 1 1 2 2 2 0 BED zinc finger zf-CHY PF05495.7 EPA06736.1 - 7.5 6.7 9.8 22 5.2 6.8 1.7 1 1 0 1 1 1 0 CHY zinc finger Tautomerase PF01361.16 EPA06738.1 - 3.1e-11 42.6 0.0 3.2e-11 42.6 0.0 1.0 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_2 PF14552.1 EPA06738.1 - 1.5e-06 28.0 0.0 1.6e-06 28.0 0.0 1.0 1 0 0 1 1 1 1 Tautomerase enzyme DUF1904 PF08921.6 EPA06738.1 - 0.038 14.0 0.0 0.041 13.9 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1904) Tautomerase_3 PF14832.1 EPA06738.1 - 0.07 13.1 0.0 0.078 12.9 0.0 1.0 1 0 0 1 1 1 0 Putative oxalocrotonate tautomerase enzyme GHMP_kinases_N PF00288.21 EPA06740.1 - 9.3e-12 44.8 0.1 1.6e-11 44.0 0.1 1.4 1 0 0 1 1 1 1 GHMP kinases N terminal domain PHP PF02811.14 EPA06740.1 - 0.01 15.6 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 PHP domain Telomere_Sde2_2 PF13297.1 EPA06740.1 - 0.016 14.4 0.2 0.06 12.6 0.0 2.0 2 0 0 2 2 2 0 Telomere stability C-terminal DUF1884 PF08967.5 EPA06740.1 - 0.042 13.8 0.4 0.11 12.5 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1884) GHMP_kinases_C PF08544.8 EPA06740.1 - 0.13 12.5 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 GHMP kinases C terminal Thymidylate_kin PF02223.12 EPA06741.1 - 6.6e-39 133.2 0.2 7.4e-39 133.0 0.1 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.1 EPA06741.1 - 0.0017 18.3 0.0 0.0021 18.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain Glyco_transf_4 PF13439.1 EPA06741.1 - 0.082 12.6 0.0 0.28 10.8 0.0 1.8 2 0 0 2 2 2 0 Glycosyltransferase Family 4 DUF1611 PF07755.6 EPA06741.1 - 0.25 9.9 2.0 5.8 5.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1611) vATP-synt_E PF01991.13 EPA06742.1 - 1.1e-21 77.0 7.2 2.4e-21 75.9 4.6 1.8 1 1 1 2 2 2 1 ATP synthase (E/31 kDa) subunit PhoU PF01895.14 EPA06742.1 - 0.0056 17.0 0.8 0.021 15.2 0.5 2.0 1 1 0 1 1 1 1 PhoU domain FliH PF02108.11 EPA06742.1 - 0.0056 16.5 0.6 0.028 14.2 0.3 2.1 1 1 0 1 1 1 1 Flagellar assembly protein FliH DUF3236 PF11576.3 EPA06742.1 - 0.0067 15.8 0.1 0.016 14.6 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3236) DUF711 PF05167.7 EPA06742.1 - 0.026 13.2 0.6 0.11 11.2 0.1 1.8 1 1 1 2 2 2 0 Uncharacterised ACR (DUF711) Prominin PF05478.6 EPA06742.1 - 0.049 11.1 1.2 0.066 10.7 0.8 1.1 1 0 0 1 1 1 0 Prominin OSCP PF00213.13 EPA06742.1 - 0.052 13.4 5.1 0.092 12.5 3.5 1.6 1 1 0 1 1 1 0 ATP synthase delta (OSCP) subunit Imm22 PF15592.1 EPA06742.1 - 0.085 13.1 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 22 YtzH PF14165.1 EPA06742.1 - 0.11 12.7 3.6 5.2 7.3 0.0 2.8 3 0 0 3 3 3 0 YtzH-like protein DUF1399 PF07173.7 EPA06742.1 - 0.91 9.8 2.8 3.2 8.0 0.3 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1399) NUDIX PF00293.23 EPA06744.1 - 8.6e-18 64.2 0.0 1.1e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain AF0941-like PF14591.1 EPA06744.1 - 0.0034 17.4 1.4 0.0057 16.7 0.4 1.8 1 1 1 2 2 2 1 AF0941-like Rhodanese PF00581.15 EPA06745.1 - 3.5e-44 149.7 0.1 1.1e-22 80.4 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain DUF334 PF03904.8 EPA06746.1 - 0.008 15.5 2.2 0.012 14.9 1.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF334) SAM_2 PF07647.12 EPA06746.1 - 0.05 13.4 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) ABC_tran PF00005.22 EPA06747.1 - 1.5e-36 125.7 0.1 1.3e-35 122.6 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 EPA06747.1 - 2.1e-15 57.4 2.9 1.5e-13 51.3 2.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.1 EPA06747.1 - 3.6e-08 32.8 3.7 0.001 18.2 1.3 2.2 1 1 1 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 EPA06747.1 - 6.8e-06 25.4 2.0 0.00026 20.3 1.4 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EPA06747.1 - 3.3e-05 23.3 0.1 6.1e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 EPA06747.1 - 0.00055 20.3 7.1 0.0019 18.5 4.9 2.0 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EPA06747.1 - 0.00068 19.0 0.2 0.76 9.1 0.0 2.6 2 1 0 2 2 2 2 IstB-like ATP binding protein MMR_HSR1 PF01926.18 EPA06747.1 - 0.00082 19.3 1.0 0.0021 17.9 0.7 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_13 PF13166.1 EPA06747.1 - 0.0011 17.5 3.0 0.091 11.2 0.5 2.1 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 EPA06747.1 - 0.0051 16.6 0.0 0.17 11.7 0.0 2.4 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit DUF258 PF03193.11 EPA06747.1 - 0.0054 15.9 0.0 0.011 14.9 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_10 PF12846.2 EPA06747.1 - 0.0096 15.3 0.5 0.3 10.5 0.2 2.3 1 1 2 3 3 3 1 AAA-like domain AAA_14 PF13173.1 EPA06747.1 - 0.017 15.0 0.8 0.82 9.5 0.0 2.4 1 1 0 2 2 2 0 AAA domain AAA PF00004.24 EPA06747.1 - 0.022 14.9 1.5 0.18 12.0 1.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 EPA06747.1 - 0.034 13.8 0.3 0.055 13.1 0.2 1.6 1 1 0 1 1 1 0 Archaeal ATPase AAA_22 PF13401.1 EPA06747.1 - 0.037 14.1 0.3 0.19 11.8 0.2 2.0 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EPA06747.1 - 0.063 13.2 0.0 0.22 11.5 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.1 EPA06747.1 - 0.068 13.0 0.0 0.25 11.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain NAP PF00956.13 EPA06747.1 - 0.081 12.0 1.0 0.11 11.5 0.5 1.3 1 1 0 1 1 1 0 Nucleosome assembly protein (NAP) Miro PF08477.8 EPA06747.1 - 0.09 13.2 0.1 0.17 12.3 0.1 1.8 1 1 0 1 1 1 0 Miro-like protein AAA_25 PF13481.1 EPA06747.1 - 0.095 12.0 0.0 0.27 10.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 EPA06747.1 - 0.14 12.9 1.0 0.76 10.6 0.7 2.4 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.12 EPA06747.1 - 0.81 9.4 5.5 6.5 6.4 1.0 2.2 1 1 1 2 2 2 0 Domain of unknown function DUF87 DegT_DnrJ_EryC1 PF01041.12 EPA06748.1 - 2.9e-115 385.1 0.0 3.2e-115 385.0 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 EPA06748.1 - 6.8e-09 35.1 0.1 1e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EPA06748.1 - 1.5e-08 33.7 0.1 2.4e-08 33.1 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EPA06748.1 - 4e-08 31.9 0.2 6.6e-08 31.2 0.1 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 EPA06748.1 - 2.3e-06 26.9 0.1 5.4e-06 25.7 0.1 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase ComK PF06338.6 EPA06748.1 - 0.024 14.0 0.0 0.05 13.0 0.0 1.5 1 0 0 1 1 1 0 ComK protein OKR_DC_1 PF01276.15 EPA06748.1 - 0.054 12.0 0.1 0.073 11.6 0.1 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain ThiI PF02568.9 EPA06749.1 - 4.6e-14 52.3 0.0 1e-13 51.1 0.0 1.5 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.11 EPA06749.1 - 8.5e-08 31.1 0.1 1.8e-07 30.0 0.0 1.5 2 0 0 2 2 2 1 tRNA methyl transferase DUF814 PF05670.8 EPA06749.1 - 7e-07 29.0 0.0 2.2e-06 27.4 0.0 1.9 2 1 0 2 2 2 1 Domain of unknown function (DUF814) Asn_synthase PF00733.16 EPA06749.1 - 9.9e-05 21.9 0.0 0.00014 21.4 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.8 EPA06749.1 - 0.0062 15.8 1.0 0.011 15.0 0.1 1.8 3 0 0 3 3 3 1 Queuosine biosynthesis protein QueC V_ATPase_I PF01496.14 EPA06750.1 - 1.6e-52 178.4 17.1 1.2e-51 175.5 11.8 1.9 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family ABC_trans_N PF14510.1 EPA06750.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 ABC-transporter extracellular N-terminal ATP-synt_C PF00137.16 EPA06752.1 - 3.9e-20 71.5 17.4 3.9e-20 71.5 12.1 1.9 2 0 0 2 2 2 1 ATP synthase subunit C DUF3693 PF12472.3 EPA06752.1 - 0.51 9.9 4.5 7.1 6.3 0.1 2.5 2 0 0 2 2 2 0 Phage related protein Flavoprotein PF02441.14 EPA06753.1 - 1.2e-28 99.3 0.4 1.4e-28 99.0 0.2 1.1 1 0 0 1 1 1 1 Flavoprotein BRCT PF00533.21 EPA06753.1 - 0.034 14.2 0.0 0.062 13.4 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain NAD_binding_7 PF13241.1 EPA06753.1 - 0.056 13.7 0.0 0.087 13.0 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Ank PF00023.25 EPA06753.1 - 0.14 11.9 0.3 0.56 10.1 0.0 2.0 2 0 0 2 2 2 0 Ankyrin repeat SGL PF08450.7 EPA06754.1 - 1.3e-14 54.2 0.1 0.00055 19.3 0.0 5.2 1 1 4 5 5 5 5 SMP-30/Gluconolaconase/LRE-like region CopC PF04234.7 EPA06754.1 - 9.1e-13 48.6 0.0 2.4e-12 47.3 0.0 1.8 1 0 0 1 1 1 1 CopC domain CopD PF05425.8 EPA06754.1 - 1e-12 48.1 2.4 1e-12 48.1 1.6 2.8 3 0 0 3 3 3 1 Copper resistance protein D Reg_prop PF07494.6 EPA06754.1 - 4.2e-08 32.2 10.8 5.8 7.2 0.2 8.3 8 0 0 8 8 8 3 Two component regulator propeller YtkA PF13115.1 EPA06754.1 - 0.022 15.1 0.0 0.082 13.2 0.0 2.0 2 0 0 2 2 2 0 YtkA-like dUTPase_2 PF08761.6 EPA06755.1 - 4.6e-19 69.1 5.9 4.8e-14 52.7 0.1 2.0 1 1 1 2 2 2 2 dUTPase PRA-PH PF01503.12 EPA06755.1 - 0.02 15.1 0.0 0.025 14.8 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase DUF550 PF04447.7 EPA06755.1 - 0.099 12.2 1.6 0.29 10.7 1.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF550) ATG16 PF08614.6 EPA06756.1 - 0.0023 17.8 12.0 0.0027 17.5 8.3 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) TBPIP PF07106.8 EPA06756.1 - 0.012 15.1 7.2 0.012 15.1 5.0 1.3 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Bap31 PF05529.7 EPA06756.1 - 0.023 14.1 6.2 0.023 14.1 3.8 1.4 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like MLANA PF14991.1 EPA06756.1 - 0.047 13.6 0.0 0.082 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein melan-A PFEMP PF03011.10 EPA06756.1 - 0.049 13.9 5.2 0.063 13.6 3.6 1.1 1 0 0 1 1 1 0 PFEMP DBL domain Vps53_N PF04100.7 EPA06756.1 - 0.052 12.3 6.8 0.059 12.1 4.7 1.1 1 0 0 1 1 1 0 Vps53-like, N-terminal Reo_sigmaC PF04582.7 EPA06756.1 - 0.083 12.0 4.5 0.074 12.2 2.0 1.3 1 1 0 1 1 1 0 Reovirus sigma C capsid protein Troponin PF00992.15 EPA06756.1 - 0.093 12.7 6.6 0.12 12.4 4.6 1.2 1 0 0 1 1 1 0 Troponin LBP_BPI_CETP_C PF02886.12 EPA06756.1 - 0.11 11.7 1.1 0.13 11.4 0.8 1.1 1 0 0 1 1 1 0 LBP / BPI / CETP family, C-terminal domain RmuC PF02646.11 EPA06756.1 - 0.13 11.0 7.5 0.072 11.9 3.9 1.4 1 1 0 1 1 1 0 RmuC family IncA PF04156.9 EPA06756.1 - 0.14 11.7 8.5 0.23 11.0 5.9 1.4 1 0 0 1 1 1 0 IncA protein CheY-binding PF09078.6 EPA06756.1 - 0.15 12.0 3.3 1 9.3 0.5 2.8 1 1 2 3 3 3 0 CheY binding Allexi_40kDa PF05549.6 EPA06756.1 - 0.16 11.2 7.1 0.19 10.9 4.9 1.0 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF1664 PF07889.7 EPA06756.1 - 0.19 11.5 3.9 0.27 11.0 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2730 PF10805.3 EPA06756.1 - 0.19 11.4 4.6 0.21 11.3 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Seryl_tRNA_N PF02403.17 EPA06756.1 - 0.22 11.5 8.0 0.13 12.2 4.0 1.5 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF641 PF04859.7 EPA06756.1 - 0.27 10.9 5.1 0.71 9.6 3.5 1.8 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Fib_alpha PF08702.5 EPA06756.1 - 0.41 10.7 8.4 0.39 10.8 5.1 1.4 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.6 EPA06756.1 - 0.87 9.5 6.8 6.2 6.8 0.2 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) LRR_4 PF12799.2 EPA06756.1 - 2 8.1 5.2 27 4.4 2.8 2.9 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) Ribosomal_L29 PF00831.18 EPA06756.1 - 2.5 7.8 7.7 2.6 7.7 1.6 2.6 1 1 1 2 2 2 0 Ribosomal L29 protein KLRAQ PF10205.4 EPA06756.1 - 8 6.5 10.9 1.8 8.6 4.7 1.9 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein DivIC PF04977.10 EPA06756.1 - 9.9 5.7 7.5 33 4.0 4.3 2.5 1 1 1 2 2 2 0 Septum formation initiator DUF1931 PF09123.6 EPA06757.1 - 0.045 13.6 0.1 0.058 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1931) COX7a PF02238.10 EPA06757.1 - 0.09 12.5 0.1 0.18 11.5 0.1 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase subunit VIIa CopD PF05425.8 EPA06758.1 - 2.8e-15 56.4 0.2 2.8e-15 56.4 0.1 1.7 2 0 0 2 2 2 1 Copper resistance protein D DUF2269 PF10027.4 EPA06758.1 - 0.0017 18.1 5.6 0.0026 17.5 3.9 1.2 1 0 0 1 1 1 1 Predicted integral membrane protein (DUF2269) UPF0093 PF03653.8 EPA06758.1 - 0.002 18.1 8.4 0.0058 16.5 5.8 1.6 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0093) 7TM_GPCR_Srv PF10323.4 EPA06758.1 - 0.0078 15.3 2.0 0.012 14.7 1.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv DUF4149 PF13664.1 EPA06758.1 - 0.019 15.0 7.4 0.24 11.5 5.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4149) Selenoprotein_S PF06936.6 EPA06758.1 - 0.084 12.4 0.2 0.12 11.9 0.2 1.1 1 0 0 1 1 1 0 Selenoprotein S (SelS) SieB PF14163.1 EPA06758.1 - 0.089 12.3 9.1 2 7.9 2.2 2.5 2 1 0 2 2 2 0 Superinfection exclusion protein B YrhC PF14143.1 EPA06758.1 - 0.36 10.7 0.1 0.36 10.7 0.1 2.6 3 1 0 3 3 3 0 YrhC-like protein Brr6_like_C_C PF10104.4 EPA06758.1 - 3.2 7.2 9.5 0.12 11.9 2.1 2.0 2 1 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain CTP_transf_2 PF01467.21 EPA06760.1 - 2.5e-16 60.1 0.0 4.1e-16 59.4 0.0 1.4 2 0 0 2 2 2 1 Cytidylyltransferase PepSY_TM_2 PF13703.1 EPA06762.1 - 1.7 8.8 5.7 0.72 10.0 1.3 2.3 1 1 1 2 2 2 0 PepSY-associated TM helix TroA PF01297.12 EPA06763.1 - 4.1e-77 258.9 0.3 4.6e-77 258.7 0.2 1.0 1 0 0 1 1 1 1 Periplasmic solute binding protein family FlgD_ig PF13860.1 EPA06764.1 - 0.013 15.2 0.0 6.8 6.5 0.0 2.9 2 0 0 2 2 2 0 FlgD Ig-like domain Wzt_C PF14524.1 EPA06764.1 - 0.025 14.2 0.5 0.12 12.0 0.1 2.2 2 0 0 2 2 2 0 Wzt C-terminal domain Peptidase_M24 PF00557.19 EPA06765.1 - 1.1e-52 178.6 0.0 1.2e-52 178.4 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 FUSC PF04632.7 EPA06766.1 - 0.58 8.5 2.6 0.65 8.3 1.8 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family FKBP_C PF00254.23 EPA06767.1 - 1.9e-12 47.0 0.6 1.2e-11 44.4 0.2 2.3 1 1 1 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPCBM_assoc PF10633.4 EPA06768.1 - 0.001 19.0 1.0 0.78 9.8 0.0 3.7 3 2 1 4 4 4 2 NPCBM-associated, NEW3 domain of alpha-galactosidase Fe-ADH_2 PF13685.1 EPA06769.1 - 2.2e-68 230.2 1.2 2.2e-68 230.2 0.8 1.4 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.14 EPA06769.1 - 1.5e-24 86.3 0.1 2.1e-24 85.8 0.1 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.15 EPA06769.1 - 2e-06 26.9 0.5 4.4e-05 22.5 0.3 2.6 1 1 0 1 1 1 1 3-dehydroquinate synthase AIRC PF00731.15 EPA06769.1 - 0.0032 16.7 1.9 0.008 15.4 0.2 2.2 2 0 0 2 2 2 1 AIR carboxylase MtrA PF04208.9 EPA06770.1 - 2.5e-24 85.7 0.3 2.9e-24 85.4 0.2 1.0 1 0 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase, subunit A AA_kinase PF00696.23 EPA06772.1 - 6.9e-31 107.6 1.2 8.4e-31 107.3 0.9 1.1 1 0 0 1 1 1 1 Amino acid kinase family DFP PF04127.10 EPA06773.1 - 1.1e-58 197.9 2.1 1.4e-58 197.6 1.5 1.1 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein NAD_binding_10 PF13460.1 EPA06773.1 - 0.0047 16.9 0.0 0.0072 16.3 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding ABC_tran PF00005.22 EPA06774.1 - 1.8e-29 102.8 0.1 2.5e-29 102.3 0.1 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EPA06774.1 - 1.9e-10 41.1 0.6 1.4e-09 38.3 0.4 1.9 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 EPA06774.1 - 2.6e-06 26.8 4.1 2.9e-05 23.4 2.8 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 EPA06774.1 - 0.00074 18.6 1.7 0.3 10.0 0.0 2.1 1 1 1 2 2 2 2 AAA ATPase domain AAA_10 PF12846.2 EPA06774.1 - 0.0012 18.3 0.3 0.0037 16.7 0.1 1.9 2 0 0 2 2 2 1 AAA-like domain AAA_29 PF13555.1 EPA06774.1 - 0.0019 17.6 0.4 0.0057 16.1 0.2 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF258 PF03193.11 EPA06774.1 - 0.0028 16.8 0.1 0.0048 16.0 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SbcCD_C PF13558.1 EPA06774.1 - 0.013 15.4 0.1 0.24 11.3 0.0 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AviRa PF11599.3 EPA06774.1 - 0.016 14.2 0.1 0.041 12.8 0.0 1.6 2 0 0 2 2 2 0 RRNA methyltransferase AviRa NYN PF01936.13 EPA06774.1 - 0.018 15.3 0.3 0.06 13.6 0.2 1.7 1 1 0 1 1 1 0 NYN domain AAA_33 PF13671.1 EPA06774.1 - 0.019 14.8 0.9 0.032 14.1 0.6 1.7 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EPA06774.1 - 0.025 14.7 0.3 0.072 13.2 0.2 2.0 1 1 0 1 1 1 0 AAA domain AAA_13 PF13166.1 EPA06774.1 - 0.044 12.2 2.3 0.14 10.6 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 EPA06774.1 - 0.044 14.1 1.2 0.054 13.8 0.8 1.4 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.18 EPA06774.1 - 0.056 13.2 1.1 0.55 10.0 0.1 2.2 2 0 0 2 2 2 0 Dynamin family MobB PF03205.9 EPA06774.1 - 0.071 12.8 0.8 0.28 10.8 0.5 2.1 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B G-alpha PF00503.15 EPA06774.1 - 0.073 11.7 0.0 0.073 11.7 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Miro PF08477.8 EPA06774.1 - 0.081 13.4 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein MMR_HSR1 PF01926.18 EPA06774.1 - 0.083 12.8 1.9 0.13 12.2 1.3 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_17 PF13207.1 EPA06774.1 - 0.089 13.6 0.9 0.11 13.2 0.6 1.8 1 1 0 1 1 1 0 AAA domain cobW PF02492.14 EPA06774.1 - 0.1 12.0 0.9 0.4 10.1 0.1 2.1 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.7 EPA06774.1 - 0.16 11.5 0.4 0.41 10.2 0.1 1.7 1 1 1 2 2 2 0 NACHT domain FtsK_SpoIIIE PF01580.13 EPA06774.1 - 0.17 11.3 1.1 0.35 10.3 0.4 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_16 PF13191.1 EPA06774.1 - 0.21 11.5 1.1 0.41 10.6 0.7 1.9 1 1 0 1 1 1 0 AAA ATPase domain Beta-Casp PF10996.3 EPA06775.1 - 9e-32 109.6 0.0 1.7e-31 108.7 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.22 EPA06775.1 - 3.2e-20 72.6 0.0 5.6e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.7 EPA06775.1 - 7e-15 54.5 0.0 3e-14 52.5 0.0 2.1 2 0 0 2 2 2 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_2 PF12706.2 EPA06775.1 - 1.9e-11 43.8 0.0 6.8e-11 42.0 0.0 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 EPA06775.1 - 0.006 16.2 0.0 0.014 15.0 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Copper-bind PF00127.15 EPA06776.1 - 0.011 15.8 0.7 0.08 13.1 0.0 2.4 2 0 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 EPA06776.1 - 0.036 13.9 0.0 0.13 12.1 0.0 2.0 1 1 0 1 1 1 0 Cupredoxin-like domain IF3_C PF00707.17 EPA06776.1 - 0.057 13.1 0.0 2.6 7.8 0.2 2.7 2 1 1 3 3 3 0 Translation initiation factor IF-3, C-terminal domain BACON PF13004.2 EPA06776.1 - 0.08 13.1 0.2 0.4 10.9 0.1 2.3 2 0 0 2 2 2 0 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal Creatinase_N PF01321.13 EPA06777.1 - 2.9e-12 47.1 0.0 3.3e-12 47.0 0.0 1.0 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain PGBA_N PF15436.1 EPA06777.1 - 0.0023 17.2 0.0 0.0028 16.9 0.0 1.3 1 0 0 1 1 1 1 Plasminogen-binding protein pgbA N-terminal DUF4428 PF14471.1 EPA06777.1 - 0.041 13.6 0.4 0.085 12.6 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) Pro_isomerase PF00160.16 EPA06778.1 - 5.9e-50 169.4 0.1 6.8e-50 169.2 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Podoplanin PF05808.6 EPA06779.1 - 0.02 14.4 0.2 0.043 13.3 0.1 1.5 1 0 0 1 1 1 0 Podoplanin DUF4064 PF13273.1 EPA06779.1 - 0.037 14.1 2.8 0.081 13.0 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF1312 PF07009.6 EPA06779.1 - 0.41 10.4 9.6 0.3 10.9 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1312) HSP20 PF00011.16 EPA06781.1 - 1.1e-13 50.9 0.2 1.4e-13 50.5 0.1 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family DHQ_synthase PF01761.15 EPA06782.1 - 0.045 12.6 0.1 0.053 12.4 0.0 1.0 1 0 0 1 1 1 0 3-dehydroquinate synthase RTC PF01137.16 EPA06783.1 - 3.6e-76 254.9 0.3 4.2e-76 254.7 0.2 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase B-block_TFIIIC PF04182.7 EPA06783.1 - 0.059 13.2 0.1 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC HTH_23 PF13384.1 EPA06784.1 - 0.0045 16.5 0.0 0.0079 15.8 0.0 1.6 1 1 0 1 1 1 1 Homeodomain-like domain HTH_IclR PF09339.5 EPA06784.1 - 0.043 13.3 0.1 0.21 11.2 0.0 1.9 2 0 0 2 2 2 0 IclR helix-turn-helix domain GntR PF00392.16 EPA06784.1 - 0.07 12.5 0.1 0.11 11.8 0.0 1.5 1 1 0 1 1 1 0 Bacterial regulatory proteins, gntR family DUF4631 PF15450.1 EPA06784.1 - 0.077 11.2 0.1 0.091 11.0 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4631) TrmB PF01978.14 EPA06784.1 - 0.13 12.0 0.0 0.33 10.6 0.0 1.7 1 1 1 2 2 2 0 Sugar-specific transcriptional regulator TrmB DnaJ_CXXCXGXG PF00684.14 EPA06786.1 - 0.083 12.9 10.9 0.5 10.4 7.6 2.1 1 1 0 1 1 1 0 DnaJ central domain Ribosomal_L33 PF00471.15 EPA06786.1 - 0.18 12.0 2.2 0.45 10.7 1.5 1.6 1 0 0 1 1 1 0 Ribosomal protein L33 Antifungal_prot PF11402.3 EPA06786.1 - 0.78 9.9 11.5 5 7.3 7.7 2.1 1 1 0 1 1 1 0 Antifungal protein zf-nanos PF05741.8 EPA06786.1 - 0.9 9.5 10.6 1.1 9.3 4.8 2.3 2 1 0 2 2 2 0 Nanos RNA binding domain DUF3268 PF11672.3 EPA06786.1 - 2.9 8.0 9.3 7.1 6.7 6.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3268) Prok-RING_2 PF14445.1 EPA06786.1 - 7.8 6.5 11.2 3.6 7.6 2.9 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 2 LEA_2 PF03168.8 EPA06787.1 - 0.0015 18.8 0.1 0.0054 17.0 0.1 1.8 1 1 0 1 1 1 1 Late embryogenesis abundant protein PhoU PF01895.14 EPA06789.1 - 2.1e-10 40.9 4.9 9.8e-07 29.1 1.2 2.8 2 0 0 2 2 2 2 PhoU domain Antitoxin-MazE PF04014.13 EPA06789.1 - 0.00029 20.5 0.0 0.00071 19.2 0.0 1.8 1 0 0 1 1 1 1 Antidote-toxin recognition MazE A2M_N_2 PF07703.9 EPA06789.1 - 0.0041 16.9 0.0 0.0079 16.0 0.0 1.3 1 0 0 1 1 1 1 Alpha-2-macroglobulin family N-terminal region TP_methylase PF00590.15 EPA06790.1 - 2.1e-36 125.5 0.0 2.5e-36 125.3 0.0 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Methyltransf_23 PF13489.1 EPA06791.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Proteasome PF00227.21 EPA06792.1 - 2.2e-52 177.1 0.2 2.5e-52 176.9 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit Glyco_hydro_1 PF00232.13 EPA06793.1 - 0.042 12.0 0.4 0.047 11.8 0.3 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 Lipoprotein_15 PF03640.10 EPA06794.1 - 0.007 15.7 0.4 0.81 9.1 0.0 2.6 2 0 0 2 2 2 2 Secreted repeat of unknown function MEDS PF14417.1 EPA06794.1 - 0.051 12.6 0.1 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain ATP-synt_D PF01813.12 EPA06795.1 - 4.9e-53 179.6 7.9 5.5e-53 179.4 5.5 1.0 1 0 0 1 1 1 1 ATP synthase subunit D DUF1395 PF07160.7 EPA06795.1 - 0.77 9.2 8.3 1.8 8.0 0.2 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1395) DUF1019 PF06254.6 EPA06795.1 - 2.9 8.1 7.3 0.62 10.2 0.6 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1019) GreA_GreB_N PF03449.10 EPA06795.1 - 6 6.9 7.8 2.1 8.4 1.3 2.6 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal Nitroreductase PF00881.19 EPA06796.1 - 2.2e-26 92.6 0.0 3.2e-26 92.1 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family ABC-3 PF00950.12 EPA06798.1 - 1.1e-65 221.5 38.4 1.2e-65 221.3 26.6 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.13 EPA06798.1 - 1.2e-06 27.6 38.0 2.2e-06 26.7 25.3 1.8 1 1 0 1 1 1 1 FecCD transport family DUF2953 PF11167.3 EPA06798.1 - 0.77 9.7 7.2 23 4.9 0.0 4.6 4 1 0 4 4 4 0 Protein of unknown function (DUF2953) Ammonium_transp PF00909.16 EPA06799.1 - 2.9e-108 361.9 33.8 8e-108 360.4 23.4 1.7 1 1 0 1 1 1 1 Ammonium Transporter Family ABC2_membrane_2 PF12679.2 EPA06800.1 - 0.021 13.6 0.0 0.021 13.6 0.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein OTCace_N PF02729.16 EPA06801.1 - 1.7e-40 137.9 0.0 2.5e-40 137.3 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 EPA06801.1 - 3.4e-37 127.7 0.0 4.9e-37 127.2 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain FMN_red PF03358.10 EPA06802.1 - 2.4e-24 85.5 0.0 3e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 EPA06802.1 - 4.3e-09 36.1 0.0 5.5e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold DUF1297 PF06973.7 EPA06802.1 - 0.062 12.6 0.1 6.1 6.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1297) DUF1461 PF07314.6 EPA06802.1 - 0.16 11.6 0.7 0.25 11.0 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1461) Rhomboid PF01694.17 EPA06803.1 - 1.6e-30 106.0 18.1 1.6e-30 106.0 12.6 1.6 2 0 0 2 2 2 1 Rhomboid family PyrI PF01948.13 EPA06804.1 - 7.4e-35 118.8 2.3 7.4e-35 118.8 1.6 1.4 2 0 0 2 2 2 1 Aspartate carbamoyltransferase regulatory chain, allosteric domain PyrI_C PF02748.10 EPA06804.1 - 3.7e-15 55.0 2.1 6.1e-15 54.3 1.5 1.3 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF1936 PF09151.5 EPA06804.1 - 0.021 14.3 0.2 0.056 12.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1936) DUF552 PF04472.7 EPA06805.1 - 4.7e-15 55.2 0.6 5.3e-15 55.1 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF552) H_kinase_N PF12282.3 EPA06805.1 - 0.024 14.2 0.0 0.037 13.6 0.0 1.2 1 0 0 1 1 1 0 Signal transduction histidine kinase ATP-synt_ab PF00006.20 EPA06807.1 - 1.7e-65 220.5 0.0 2.4e-65 220.0 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EPA06807.1 - 1.1e-13 51.6 0.1 2e-13 50.8 0.1 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EPA06807.1 - 3.1e-11 43.3 2.3 7.5e-11 42.0 1.6 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 EPA06807.1 - 8.5e-05 22.3 1.8 0.00016 21.5 0.5 2.1 2 0 0 2 2 2 1 HAS barrel domain HTH_AsnC-type PF13404.1 EPA06808.1 - 7e-19 67.0 0.8 3.3e-12 45.7 0.1 2.4 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain HTH_24 PF13412.1 EPA06808.1 - 2.2e-18 65.3 10.4 6.7e-11 41.4 1.2 2.5 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding TrmB PF01978.14 EPA06808.1 - 6e-08 32.2 0.3 0.0078 15.8 0.0 2.4 2 0 0 2 2 2 2 Sugar-specific transcriptional regulator TrmB MarR PF01047.17 EPA06808.1 - 2e-06 27.4 1.9 0.00079 19.0 0.2 2.4 2 0 0 2 2 2 2 MarR family HTH_11 PF08279.7 EPA06808.1 - 0.00012 21.6 3.4 0.036 13.7 0.3 2.8 2 0 0 2 2 2 2 HTH domain Mga PF05043.8 EPA06808.1 - 0.00023 21.3 0.2 0.049 13.9 0.1 2.6 2 0 0 2 2 2 1 Mga helix-turn-helix domain MarR_2 PF12802.2 EPA06808.1 - 0.00036 20.1 0.0 0.79 9.4 0.0 2.3 2 0 0 2 2 2 2 MarR family HTH_23 PF13384.1 EPA06808.1 - 0.002 17.7 0.0 1.2 8.8 0.0 2.7 2 0 0 2 2 2 2 Homeodomain-like domain Trp_repressor PF01371.14 EPA06808.1 - 0.0056 16.5 1.3 0.064 13.1 0.1 2.7 3 0 0 3 3 3 1 Trp repressor protein HTH_34 PF13601.1 EPA06808.1 - 0.0078 16.2 0.0 2 8.4 0.0 2.4 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_Mga PF08280.6 EPA06808.1 - 0.012 15.3 3.8 0.012 15.3 2.6 3.3 3 0 0 3 3 3 0 M protein trans-acting positive regulator (MGA) HTH domain TFIIE_alpha PF02002.12 EPA06808.1 - 0.019 14.4 2.2 0.62 9.5 0.2 2.5 2 0 0 2 2 2 0 TFIIE alpha subunit DUF1366 PF07104.6 EPA06808.1 - 0.03 13.9 0.5 0.03 13.9 0.3 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF1366) PAH PF02671.16 EPA06808.1 - 0.059 12.9 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Paired amphipathic helix repeat DUF2250 PF10007.4 EPA06808.1 - 0.066 13.1 2.1 3.4 7.6 0.1 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) GerE PF00196.14 EPA06808.1 - 0.067 12.5 4.1 4.6 6.6 0.2 3.2 3 0 0 3 3 3 0 Bacterial regulatory proteins, luxR family HTH_45 PF14947.1 EPA06808.1 - 0.082 12.7 1.7 0.43 10.4 0.1 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix HTH_36 PF13730.1 EPA06808.1 - 0.13 12.4 0.7 0.32 11.1 0.1 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain LON PF02190.11 EPA06809.1 - 4.8e-21 75.3 0.1 6.3e-21 75.0 0.1 1.2 1 0 0 1 1 1 1 ATP-dependent protease La (LON) domain Pantoate_transf PF02548.10 EPA06810.1 - 7.9e-109 362.7 2.9 8.9e-109 362.6 2.0 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.1 EPA06810.1 - 0.00026 20.2 0.4 0.0019 17.4 0.1 2.2 1 1 2 3 3 3 2 Phosphoenolpyruvate phosphomutase vATP-synt_AC39 PF01992.11 EPA06811.1 - 6e-37 127.5 8.9 7.1e-37 127.2 6.2 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit DNA_ligase_OB PF03120.11 EPA06811.1 - 0.027 14.1 0.1 8.2 6.1 0.0 3.0 3 0 0 3 3 3 0 NAD-dependent DNA ligase OB-fold domain Fibritin_C PF07921.7 EPA06811.1 - 0.029 14.2 0.1 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 Fibritin C-terminal region Mak16 PF04874.9 EPA06811.1 - 0.075 13.1 0.8 2.6 8.1 0.0 2.8 3 0 0 3 3 3 0 Mak16 protein C-terminal region ATP-synt_ab PF00006.20 EPA06812.1 - 1.2e-95 319.0 0.0 1.9e-95 318.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EPA06812.1 - 5.2e-14 52.6 1.1 8.6e-14 51.9 0.8 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EPA06812.1 - 1.3e-12 47.7 0.6 3.1e-12 46.5 0.4 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_19 PF13245.1 EPA06812.1 - 0.0071 16.0 0.1 0.15 11.8 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 EPA06812.1 - 0.072 13.2 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF853 PF05872.7 EPA06812.1 - 0.1 10.9 0.4 0.16 10.3 0.3 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) tRNA-synt_1b PF00579.20 EPA06813.1 - 4.9e-42 144.0 0.1 6.2e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Multi_Drug_Res PF00893.14 EPA06814.1 - 0.0098 16.3 1.5 0.011 16.1 1.0 1.1 1 0 0 1 1 1 1 Small Multidrug Resistance protein DUF2975 PF11188.3 EPA06814.1 - 0.04 13.6 1.7 0.042 13.5 1.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) Phageshock_PspG PF09583.5 EPA06814.1 - 0.11 12.6 0.3 0.11 12.6 0.2 1.7 2 0 0 2 2 2 0 Phage shock protein G (Phageshock_PspG) SdpI PF13630.1 EPA06814.1 - 0.14 11.9 2.7 0.16 11.6 1.9 1.2 1 0 0 1 1 1 0 SdpI/YhfL protein family Class_IIIsignal PF04021.7 EPA06814.1 - 2.5 7.9 7.7 0.19 11.4 0.9 2.1 2 0 0 2 2 2 0 Class III signal peptide MpPF26 PF07666.6 EPA06814.1 - 3.2 7.6 6.0 3.1 7.6 0.1 2.0 1 1 1 2 2 2 0 M penetrans paralogue family 26 ABC1 PF03109.11 EPA06815.1 - 4.6e-23 81.4 0.0 1.6e-22 79.6 0.0 1.9 2 0 0 2 2 2 1 ABC1 family APH PF01636.18 EPA06815.1 - 0.0088 15.8 0.0 0.034 13.8 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family CBS PF00571.23 EPA06816.1 - 1.6e-47 159.0 2.3 2e-13 49.9 0.0 4.1 4 0 0 4 4 4 4 CBS domain Sigma54_DBD PF04552.8 EPA06816.1 - 0.023 14.2 0.0 0.048 13.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54, DNA binding domain SIR2 PF02146.12 EPA06817.1 - 7.9e-53 178.8 0.0 9.6e-53 178.5 0.0 1.1 1 0 0 1 1 1 1 Sir2 family Ldh_1_C PF02866.13 EPA06818.1 - 3.2e-26 92.0 0.7 1.7e-25 89.7 0.1 2.0 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 EPA06818.1 - 5.8e-24 84.5 1.3 1e-23 83.7 0.9 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Glyco_hydro_4 PF02056.11 EPA06818.1 - 2.9e-06 26.7 0.2 1.4e-05 24.4 0.1 2.1 1 1 1 2 2 2 1 Family 4 glycosyl hydrolase Shikimate_DH PF01488.15 EPA06818.1 - 4.6e-05 23.5 0.2 9.2e-05 22.5 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.18 EPA06818.1 - 0.00036 20.3 0.4 0.0013 18.4 0.2 2.0 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.12 EPA06818.1 - 0.017 15.5 0.4 0.057 13.8 0.1 2.0 1 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent AA_permease_2 PF13520.1 EPA06820.1 - 3.2e-51 174.2 61.3 6.1e-51 173.2 42.6 1.3 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EPA06820.1 - 1.4e-44 152.2 54.8 2.3e-44 151.5 38.0 1.3 1 1 0 1 1 1 1 Amino acid permease Chordopox_A13L PF05961.6 EPA06820.1 - 0.054 13.4 0.0 0.054 13.4 0.0 3.0 3 0 0 3 3 3 0 Chordopoxvirus A13L protein AsnC_trans_reg PF01037.16 EPA06821.1 - 4.7e-08 32.6 0.1 4.9e-08 32.5 0.1 1.1 1 0 0 1 1 1 1 AsnC family UPF0020 PF01170.13 EPA06823.1 - 1.2e-23 83.5 0.0 1.4e-23 83.3 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 EPA06823.1 - 5.7e-17 61.8 0.0 6.9e-17 61.5 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA06823.1 - 3.9e-12 46.0 0.1 4.4e-12 45.8 0.1 1.0 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.13 EPA06823.1 - 2e-11 43.8 0.0 1.1e-09 38.1 0.0 2.1 2 0 0 2 2 2 1 DNA methylase Methyltransf_25 PF13649.1 EPA06823.1 - 2.5e-06 27.7 0.0 3e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 EPA06823.1 - 2.9e-06 26.8 0.0 3e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_18 PF12847.2 EPA06823.1 - 3.4e-06 27.6 0.0 3.7e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 EPA06823.1 - 2.1e-05 24.2 0.0 2.2e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_11 PF08241.7 EPA06823.1 - 4.6e-05 23.8 0.0 5.4e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 EPA06823.1 - 5.8e-05 22.6 0.0 7.1e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase N6_Mtase PF02384.11 EPA06823.1 - 0.00019 20.5 0.0 0.00025 20.2 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_5 PF01795.14 EPA06823.1 - 0.00038 19.8 0.0 0.00039 19.7 0.0 1.1 1 0 0 1 1 1 1 MraW methylase family PrmA PF06325.8 EPA06823.1 - 0.00047 19.3 0.0 0.00061 18.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 EPA06823.1 - 0.00069 19.0 0.0 0.00069 19.0 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.15 EPA06823.1 - 0.0025 16.9 0.0 0.0026 16.9 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MethyltransfD12 PF02086.10 EPA06823.1 - 0.0083 15.6 0.0 0.0091 15.4 0.0 1.3 1 1 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Ubie_methyltran PF01209.13 EPA06823.1 - 0.011 14.8 0.1 0.012 14.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 EPA06823.1 - 0.049 14.0 0.0 0.058 13.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF43 PF01861.11 EPA06823.1 - 0.06 12.3 0.0 0.08 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF43 EGL-1 PF11430.3 EPA06823.1 - 6.5 6.4 9.6 13 5.4 0.0 3.4 4 0 0 4 4 4 0 Programmed cell death activator EGL-1 Lactamase_B_2 PF12706.2 EPA06824.1 - 1e-25 90.4 0.0 1.4e-25 89.9 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 EPA06824.1 - 8.8e-09 35.2 0.0 3.8e-07 29.9 0.0 2.4 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.1 EPA06824.1 - 0.00054 19.3 0.0 0.0012 18.2 0.0 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease DnaJ PF00226.26 EPA06825.1 - 1.7e-12 46.9 0.1 4.7e-12 45.4 0.0 1.9 2 0 0 2 2 2 1 DnaJ domain P-II PF00543.17 EPA06826.1 - 3.4e-20 72.4 4.3 4e-20 72.1 3.0 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DSPc PF00782.15 EPA06828.1 - 1.6e-17 63.2 0.0 2.2e-17 62.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EPA06828.1 - 2.3e-09 36.9 0.2 8.9e-09 35.0 0.1 1.8 1 1 1 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 EPA06828.1 - 2.4e-07 30.9 0.0 3.7e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate CDKN3 PF05706.7 EPA06828.1 - 0.0013 18.1 0.0 0.0019 17.6 0.0 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.1 EPA06828.1 - 0.0065 16.7 0.1 0.012 15.8 0.1 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.8 EPA06828.1 - 0.082 12.2 0.0 0.14 11.4 0.0 1.4 1 1 0 1 1 1 0 Tyrosine phosphatase family Rep_trans PF02486.14 EPA06828.1 - 0.087 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Replication initiation factor THUMP PF02926.12 EPA06830.1 - 0.00048 20.0 0.1 0.00092 19.1 0.1 1.7 1 1 0 1 1 1 1 THUMP domain Cnd1 PF12717.2 EPA06830.1 - 0.039 13.8 0.2 0.058 13.2 0.2 1.3 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HTH_IclR PF09339.5 EPA06831.1 - 5.1e-05 22.7 0.0 8.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_20 PF12840.2 EPA06831.1 - 5.3e-05 22.9 0.0 7.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.14 EPA06831.1 - 0.00023 20.7 0.1 0.00032 20.3 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB DUF742 PF05331.6 EPA06831.1 - 0.0067 16.0 0.0 0.0084 15.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF742) FUR PF01475.14 EPA06831.1 - 0.022 14.6 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Ferric uptake regulator family DND1_DSRM PF14709.1 EPA06831.1 - 0.042 14.1 0.1 0.099 12.9 0.0 1.6 2 0 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 HTH_Tnp_ISL3 PF13542.1 EPA06831.1 - 0.045 12.9 0.0 0.072 12.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_5 PF01022.15 EPA06831.1 - 0.055 13.1 0.0 0.087 12.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_24 PF13412.1 EPA06831.1 - 0.063 12.6 0.0 0.15 11.4 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Hpr_kinase_N PF02603.11 EPA06831.1 - 0.12 12.0 0.1 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 HPr Serine kinase N terminus HTH_23 PF13384.1 EPA06831.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Radical_SAM PF04055.16 EPA06833.1 - 1.8e-13 50.9 0.3 7.8e-13 48.9 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.1 EPA06833.1 - 0.0022 18.0 2.0 0.0025 17.9 0.0 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain DUF3419 PF11899.3 EPA06833.1 - 0.0093 14.7 0.0 0.013 14.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) RadC PF04002.10 EPA06833.1 - 0.09 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 RadC-like JAB domain zf-FCS PF06467.9 EPA06833.1 - 1.3 8.6 16.8 0.22 11.1 0.7 3.2 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif PCNA_N PF00705.13 EPA06834.1 - 3.9e-20 71.6 0.1 6.9e-20 70.8 0.1 1.3 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 EPA06834.1 - 1.6e-17 63.6 0.7 2.2e-16 59.9 0.0 2.5 2 1 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.8 EPA06834.1 - 0.0015 17.7 0.0 0.0017 17.5 0.0 1.1 1 0 0 1 1 1 1 Rad9 Pox_A51 PF04948.8 EPA06834.1 - 0.033 12.8 0.2 0.044 12.4 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A51 protein Receptor_2B4 PF11465.3 EPA06834.1 - 0.11 12.3 0.1 0.27 11.1 0.0 1.7 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 CBS PF00571.23 EPA06835.1 - 3.4e-47 157.9 6.7 1.8e-15 56.3 0.2 4.1 4 0 0 4 4 4 4 CBS domain Fer4 PF00037.22 EPA06836.1 - 1.7e-11 43.2 10.5 4.3e-07 29.2 0.5 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 EPA06836.1 - 1e-09 38.6 3.7 1.5e-09 38.1 2.6 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.2 EPA06836.1 - 1.6e-09 37.2 8.6 3.7e-05 23.4 0.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.1 EPA06836.1 - 9.5e-08 31.7 3.3 1.6e-07 31.0 2.3 1.3 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.1 EPA06836.1 - 9.7e-08 31.7 1.6 1.4e-07 31.2 1.1 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.2 EPA06836.1 - 2.6e-07 30.1 8.9 0.0032 17.2 0.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.1 EPA06836.1 - 1.6e-05 25.0 8.2 0.00017 21.7 5.9 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.2 EPA06836.1 - 1.8e-05 24.7 7.8 0.03 14.6 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.1 EPA06836.1 - 6.3e-05 23.6 1.0 0.17 12.6 0.0 2.1 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_3 PF12798.2 EPA06836.1 - 7.7e-05 22.9 12.3 0.043 14.3 2.9 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.1 EPA06836.1 - 8.6e-05 22.8 5.2 0.14 12.5 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_8 PF13183.1 EPA06836.1 - 0.0002 21.3 3.9 0.00055 19.9 2.8 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_15 PF13459.1 EPA06836.1 - 0.00024 21.5 9.6 0.012 16.1 0.7 2.7 1 1 1 2 2 2 2 4Fe-4S single cluster domain Fer4_18 PF13746.1 EPA06836.1 - 0.00057 20.2 6.2 0.041 14.3 1.5 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.1 EPA06836.1 - 0.0026 18.0 5.6 0.056 13.7 3.8 2.1 1 1 0 1 1 1 1 4Fe-4S dicluster domain Pribosyltran_N PF13793.1 EPA06837.1 - 1.4e-29 102.1 0.3 3e-29 101.1 0.1 1.7 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 EPA06837.1 - 1.4e-17 63.6 0.1 1.4e-17 63.6 0.1 2.5 4 0 0 4 4 4 1 Phosphoribosyl transferase domain Pribosyl_synth PF14572.1 EPA06837.1 - 3.4e-14 53.0 1.4 1.8e-12 47.4 0.3 2.9 2 1 1 3 3 3 1 Phosphoribosyl synthetase-associated domain UPRTase PF14681.1 EPA06837.1 - 7.9e-05 21.9 0.1 0.00019 20.7 0.0 1.6 2 0 0 2 2 2 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.1 EPA06837.1 - 0.0018 17.6 0.1 0.0039 16.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase Asp_Glu_race PF01177.17 EPA06837.1 - 0.0081 16.0 0.1 0.79 9.5 0.0 2.1 2 0 0 2 2 2 1 Asp/Glu/Hydantoin racemase Glyco_transf_52 PF07922.6 EPA06837.1 - 0.081 11.9 4.7 0.043 12.8 0.4 2.2 2 0 0 2 2 2 0 Glycosyltransferase family 52 TFIIS_C PF01096.13 EPA06838.1 - 9.9e-20 69.8 5.6 9.9e-20 69.8 3.9 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) DZR PF12773.2 EPA06838.1 - 8.5e-06 25.4 7.4 0.0046 16.7 1.3 2.3 2 0 0 2 2 2 2 Double zinc ribbon Zn_Tnp_IS1595 PF12760.2 EPA06838.1 - 0.00024 20.8 9.6 0.0017 18.0 0.2 3.3 2 1 1 3 3 3 1 Transposase zinc-ribbon domain Elf1 PF05129.8 EPA06838.1 - 0.0066 16.1 5.7 0.058 13.0 0.3 2.3 1 1 1 2 2 2 1 Transcription elongation factor Elf1 like zf-DNA_Pol PF08996.5 EPA06838.1 - 0.0073 15.6 0.5 0.0073 15.6 0.4 2.3 1 1 1 2 2 2 1 DNA Polymerase alpha zinc finger Prok-RING_1 PF14446.1 EPA06838.1 - 0.012 15.3 2.1 0.012 15.3 1.4 2.9 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 RNA_POL_M_15KD PF02150.11 EPA06838.1 - 0.019 14.6 16.8 0.59 9.8 4.3 3.6 2 2 1 3 3 3 0 RNA polymerases M/15 Kd subunit zf-GRF PF06839.7 EPA06838.1 - 0.029 14.3 0.7 0.029 14.3 0.5 2.5 3 0 0 3 3 3 0 GRF zinc finger zinc_ribbon_5 PF13719.1 EPA06838.1 - 0.032 13.7 16.8 1 9.0 0.6 4.1 3 1 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA06838.1 - 0.042 13.5 16.7 0.79 9.4 0.5 4.1 3 1 0 3 3 3 0 zinc-ribbon domain C1_4 PF07975.7 EPA06838.1 - 0.054 13.4 8.9 4 7.5 0.1 3.2 3 0 0 3 3 3 0 TFIIH C1-like domain zf-ribbon_3 PF13248.1 EPA06838.1 - 0.08 12.1 10.6 0.55 9.5 0.1 4.0 4 0 0 4 4 4 0 zinc-ribbon domain Ribosomal_L44 PF00935.14 EPA06838.1 - 0.099 12.6 6.2 13 5.8 0.9 3.1 3 0 0 3 3 3 0 Ribosomal protein L44 zf-NADH-PPase PF09297.6 EPA06838.1 - 0.18 11.3 10.4 0.16 11.5 1.9 3.7 3 1 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.1 EPA06838.1 - 0.18 11.3 15.3 7.6 6.1 0.0 3.7 3 1 0 3 3 3 0 zinc-ribbon domain C1_2 PF03107.11 EPA06838.1 - 0.26 11.4 0.4 0.26 11.4 0.3 2.8 4 0 0 4 4 3 0 C1 domain A2L_zn_ribbon PF08792.5 EPA06838.1 - 0.28 10.6 11.8 1.2 8.6 0.1 3.9 4 0 0 4 4 4 0 A2L zinc ribbon domain Baculo_LEF5_C PF11792.3 EPA06838.1 - 0.33 10.3 0.1 0.33 10.3 0.1 3.1 4 0 0 4 4 3 0 Baculoviridae late expression factor 5 C-terminal domain Zn-ribbon_8 PF09723.5 EPA06838.1 - 0.41 10.6 14.9 5.1 7.1 0.0 4.2 3 1 0 3 3 3 0 Zinc ribbon domain C1_1 PF00130.17 EPA06838.1 - 0.42 10.3 9.2 1.3 8.8 0.9 2.7 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-MYND PF01753.13 EPA06838.1 - 0.54 10.1 9.7 0.57 10.1 0.6 2.4 2 0 0 2 2 2 0 MYND finger zinc-ribbons_6 PF07191.7 EPA06838.1 - 0.77 9.5 11.6 0.051 13.3 1.3 2.9 1 1 1 3 3 3 0 zinc-ribbons HypA PF01155.14 EPA06838.1 - 0.89 9.2 12.4 0.34 10.6 1.7 2.8 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family OrfB_Zn_ribbon PF07282.6 EPA06838.1 - 0.99 9.1 12.4 0.49 10.0 1.0 3.0 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zf-H2C2_5 PF13909.1 EPA06838.1 - 2 8.8 0.1 2 8.8 0.1 3.1 4 0 0 4 4 2 0 C2H2-type zinc-finger domain zf-C4pol PF14260.1 EPA06838.1 - 2 8.4 7.6 3.3 7.7 2.8 2.4 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta zf-H2C2_2 PF13465.1 EPA06838.1 - 3 8.3 16.5 5.7 7.4 0.6 4.0 3 1 1 4 4 4 0 Zinc-finger double domain DUF3795 PF12675.2 EPA06838.1 - 3.2 7.9 10.7 0.76 9.9 4.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3795) zf-C4_Topoisom PF01396.14 EPA06838.1 - 3.4 7.2 13.9 6.4 6.3 2.2 3.7 3 1 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger IBR PF01485.16 EPA06838.1 - 4.3 7.2 13.0 59 3.6 6.3 2.9 2 1 0 2 2 2 0 IBR domain zf-Mss51 PF13824.1 EPA06838.1 - 4.4 7.2 10.2 7.5 6.4 1.6 3.0 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Lar_restr_allev PF14354.1 EPA06838.1 - 6.8 7.0 12.7 9 6.6 5.2 3.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar zf-AN1 PF01428.11 EPA06838.1 - 7.2 6.5 9.9 13 5.7 0.1 3.2 3 0 0 3 3 3 0 AN1-like Zinc finger Zn_Tnp_IS1 PF03811.8 EPA06838.1 - 8.3 5.9 18.7 10 5.7 3.7 4.0 2 2 1 3 3 3 0 InsA N-terminal domain HAMP PF00672.20 EPA06841.1 - 2.4e-16 59.6 1.7 5.6e-16 58.4 0.0 2.2 2 0 0 2 2 2 1 HAMP domain Guanylate_cyc PF00211.15 EPA06841.1 - 4.5e-12 45.7 0.1 1.2e-11 44.2 0.0 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Aminotran_5 PF00266.14 EPA06842.1 - 1.3e-70 238.0 0.0 1.5e-70 237.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 EPA06842.1 - 2.6e-07 29.9 0.0 3.8e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II YgbB PF02542.11 EPA06842.1 - 0.0097 15.7 0.1 0.019 14.8 0.1 1.5 1 0 0 1 1 1 1 YgbB family EF-hand_1 PF00036.27 EPA06842.1 - 0.039 13.2 0.5 0.1 11.9 0.4 1.7 1 0 0 1 1 1 0 EF hand Usp PF00582.21 EPA06843.1 - 5.4e-29 101.1 0.3 6e-29 101.0 0.2 1.0 1 0 0 1 1 1 1 Universal stress protein family DUF523 PF04463.7 EPA06843.1 - 0.12 12.1 0.1 0.46 10.2 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF523) Na_Ca_ex PF01699.19 EPA06844.1 - 2.1e-42 144.0 35.9 1.6e-25 89.3 10.4 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF788 PF05620.6 EPA06844.1 - 6 6.7 10.3 1 9.1 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF788) Usp PF00582.21 EPA06845.1 - 5e-31 107.7 0.0 6.1e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family GARS_N PF02844.10 EPA06845.1 - 0.06 13.8 0.0 13 6.3 0.0 2.3 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, N domain DUF3880 PF12996.2 EPA06845.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 DUF based on E. rectale Gene description (DUF3880) Cyclase PF04199.8 EPA06846.1 - 1.8e-32 112.3 0.0 2.2e-32 112.0 0.0 1.1 1 0 0 1 1 1 1 Putative cyclase Copper-bind PF00127.15 EPA06847.1 - 1.4e-07 31.6 0.0 3.3e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 EPA06847.1 - 0.009 15.8 0.1 0.17 11.7 0.0 3.2 4 1 0 4 4 4 1 Cupredoxin-like domain HYR PF02494.11 EPA06850.1 - 9.7e-11 41.5 1.2 3e-10 39.9 0.3 2.4 2 0 0 2 2 2 1 HYR domain Copper-bind PF00127.15 EPA06850.1 - 1.8e-07 31.3 0.0 9.4e-07 28.9 0.0 2.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family DUF4352 PF11611.3 EPA06850.1 - 8.7e-06 25.8 0.6 6.5e-05 23.0 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4352) Cupredoxin_1 PF13473.1 EPA06850.1 - 6.9e-05 22.6 0.1 0.00032 20.5 0.0 2.2 2 0 0 2 2 2 1 Cupredoxin-like domain ADIP PF11559.3 EPA06851.1 - 0.013 15.3 0.1 0.014 15.2 0.1 1.0 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4248 PF14053.1 EPA06851.1 - 0.059 12.9 0.1 0.18 11.3 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4248) Syntaxin_2 PF14523.1 EPA06851.1 - 0.088 12.8 0.1 0.1 12.6 0.1 1.2 1 0 0 1 1 1 0 Syntaxin-like protein Spc24 PF08286.6 EPA06851.1 - 0.098 12.3 0.1 0.11 12.2 0.1 1.1 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Asp_Glu_race PF01177.17 EPA06853.1 - 8.8e-17 61.7 0.0 1.1e-16 61.4 0.0 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase Redoxin PF08534.5 EPA06853.1 - 0.058 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Redoxin MutS_IV PF05190.13 EPA06853.1 - 0.15 12.2 0.3 0.15 12.2 0.2 2.0 3 0 0 3 3 3 0 MutS family domain IV DUF416 PF04222.7 EPA06855.1 - 0.026 13.6 0.1 0.026 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF416) DUF2072 PF09845.4 EPA06855.1 - 0.036 13.9 0.1 0.04 13.8 0.1 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) HNH PF01844.18 EPA06856.1 - 0.0071 16.1 9.2 3 7.8 0.3 4.1 3 1 0 3 3 3 3 HNH endonuclease HemolysinCabind PF00353.14 EPA06857.1 - 5.4e-14 51.1 81.4 0.00011 22.2 2.2 9.6 7 1 2 10 10 10 6 Hemolysin-type calcium-binding repeat (2 copies) Cu-binding_MopE PF11617.3 EPA06857.1 - 1.6e-07 30.9 7.7 1.6e-07 30.9 5.4 3.1 2 0 0 2 2 2 1 Protein metal binding site Collagen PF01391.13 EPA06857.1 - 0.021 14.3 13.8 1.4 8.5 4.5 2.6 1 1 1 2 2 2 0 Collagen triple helix repeat (20 copies) tRNA-synt_2b PF00587.20 EPA06858.1 - 6.5e-48 162.5 0.1 1.5e-47 161.3 0.1 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EPA06858.1 - 2.7e-17 62.5 0.2 6.4e-17 61.2 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain Zn-ribbon_8 PF09723.5 EPA06858.1 - 0.052 13.4 0.5 15 5.6 0.0 2.7 2 0 0 2 2 2 0 Zinc ribbon domain zf-TFIIB PF13453.1 EPA06858.1 - 0.095 11.9 0.5 6.8 5.9 0.0 2.6 2 0 0 2 2 2 0 Transcription factor zinc-finger zinc_ribbon_5 PF13719.1 EPA06858.1 - 0.19 11.3 3.1 6.5 6.4 0.2 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EPA06858.1 - 0.33 10.6 3.0 13 5.5 0.2 2.7 2 0 0 2 2 2 0 zinc-ribbon domain DUF3172 PF11371.3 EPA06859.1 - 0.07 12.6 0.2 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3172) DUF204 PF02659.10 EPA06860.1 - 0.26 11.4 2.0 1.2 9.3 1.4 1.9 1 1 0 1 1 1 0 Domain of unknown function DUF ATP-synt_C PF00137.16 EPA06860.1 - 1.4 8.8 7.1 0.25 11.2 1.1 2.0 1 1 1 2 2 2 0 ATP synthase subunit C Yip1 PF04893.12 EPA06861.1 - 0.25 10.8 4.7 0.51 9.8 3.3 1.7 1 1 0 1 1 1 0 Yip1 domain HTH_20 PF12840.2 EPA06862.1 - 6.9e-07 28.9 0.0 9.7e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.14 EPA06862.1 - 1.4e-06 27.9 0.2 1.9e-06 27.5 0.2 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 EPA06862.1 - 1.7e-05 24.1 1.5 6.7e-05 22.1 1.2 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.5 EPA06862.1 - 0.0012 18.4 0.0 0.002 17.7 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain DUF1492 PF07374.6 EPA06862.1 - 0.0014 18.6 0.4 0.0031 17.5 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1492) HTH_5 PF01022.15 EPA06862.1 - 0.0014 18.1 0.4 0.0021 17.6 0.2 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_11 PF08279.7 EPA06862.1 - 0.0015 18.1 0.8 0.0026 17.3 0.5 1.5 1 1 0 1 1 1 1 HTH domain Mga PF05043.8 EPA06862.1 - 0.0088 16.3 0.1 0.013 15.7 0.1 1.4 1 0 0 1 1 1 1 Mga helix-turn-helix domain HTH_23 PF13384.1 EPA06862.1 - 0.013 15.1 0.0 0.04 13.5 0.0 1.8 1 1 1 2 2 2 0 Homeodomain-like domain MarR_2 PF12802.2 EPA06862.1 - 0.015 14.9 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 MarR family Sigma70_r4 PF04545.11 EPA06862.1 - 0.034 13.4 0.0 0.065 12.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 FUR PF01475.14 EPA06862.1 - 0.036 13.9 0.1 0.05 13.5 0.1 1.4 1 0 0 1 1 1 0 Ferric uptake regulator family HTH_27 PF13463.1 EPA06862.1 - 0.039 14.2 0.3 0.058 13.7 0.2 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_8 PF02954.14 EPA06862.1 - 0.068 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Rrf2 PF02082.15 EPA06862.1 - 0.099 12.7 0.3 0.16 12.0 0.2 1.3 1 0 0 1 1 1 0 Transcriptional regulator HTH_34 PF13601.1 EPA06862.1 - 0.11 12.4 0.6 0.35 10.9 0.2 1.8 2 0 0 2 2 2 0 Winged helix DNA-binding domain Peptidase_S8 PF00082.17 EPA06863.1 - 7.5e-17 61.3 0.0 1.2e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 Subtilase family SH3_3 PF08239.6 EPA06865.1 - 0.00039 20.5 0.3 0.0012 19.0 0.2 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain FACT-Spt16_Nlob PF14826.1 EPA06865.1 - 0.002 17.7 1.7 0.002 17.7 1.2 2.2 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain UPF0102 PF02021.12 EPA06865.1 - 0.0032 17.3 0.9 0.055 13.4 0.0 2.6 2 0 0 2 2 2 1 Uncharacterised protein family UPF0102 SH3_9 PF14604.1 EPA06865.1 - 0.0072 15.8 0.2 0.016 14.8 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain Leptin PF02024.10 EPA06865.1 - 0.16 11.6 0.7 5.7 6.5 0.3 2.3 1 1 1 2 2 2 0 Leptin Trypan_PARP PF05887.6 EPA06867.1 - 0.13 12.1 3.6 0.24 11.2 2.5 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) UBA_3 PF09288.5 EPA06868.1 - 0.0036 16.8 0.1 0.0088 15.6 0.1 1.7 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Phage_integrase PF00589.17 EPA06870.1 - 0.0005 19.7 0.1 0.012 15.2 0.0 2.9 2 1 0 2 2 2 1 Phage integrase family Peptidase_S49_N PF08496.5 EPA06870.1 - 0.12 12.1 1.4 0.77 9.5 0.0 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal T5orf172 PF10544.4 EPA06871.1 - 1.2e-08 35.2 0.0 2.2e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 T5orf172 domain MUG113 PF13455.1 EPA06871.1 - 7.7e-08 32.6 0.0 1.7e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 NERD PF08378.6 EPA06872.1 - 0.0004 20.6 1.3 0.00071 19.8 0.9 1.7 1 1 0 1 1 1 1 Nuclease-related domain Hjc PF01870.13 EPA06872.1 - 0.017 14.6 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 Archaeal holliday junction resolvase (hjc) VRR_NUC PF08774.6 EPA06872.1 - 0.038 14.0 0.0 0.066 13.2 0.0 1.5 1 0 0 1 1 1 0 VRR-NUC domain DUF1626 PF07788.6 EPA06872.1 - 0.044 13.5 0.1 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1626) Methyltransf_12 PF08242.7 EPA06873.1 - 1.3e-09 38.4 0.2 2e-09 37.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EPA06873.1 - 2.1e-09 37.1 3.0 2.7e-09 36.8 2.1 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EPA06873.1 - 8.4e-09 35.8 0.1 1.3e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EPA06873.1 - 1.6e-08 34.8 0.1 2.4e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.13 EPA06873.1 - 7.1e-08 31.9 1.2 0.0077 15.5 0.0 2.6 2 1 1 3 3 3 2 CheR methyltransferase, SAM binding domain Methyltransf_18 PF12847.2 EPA06873.1 - 8.2e-07 29.5 0.1 1.3e-06 28.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 EPA06873.1 - 3.2e-05 23.6 0.1 6.2e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EPA06873.1 - 0.0022 17.0 0.7 0.0063 15.5 0.1 1.9 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_23 PF13489.1 EPA06873.1 - 0.0027 17.4 0.0 0.0039 16.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EPA06873.1 - 0.0053 16.7 0.0 0.012 15.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EPA06873.1 - 0.06 13.3 0.2 0.073 13.0 0.2 1.3 1 1 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.14 EPA06873.1 - 0.071 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Topoisom_I PF01028.15 EPA06874.1 - 9.9e-66 221.1 11.2 9.9e-66 221.1 7.8 2.0 1 1 1 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 EPA06874.1 - 1.9e-24 85.1 1.1 1.9e-24 85.1 0.8 2.7 2 0 0 2 2 2 1 C-terminal topoisomerase domain Topoisom_I_N PF02919.10 EPA06874.1 - 7.9e-18 64.5 0.9 7.9e-18 64.5 0.7 3.0 2 1 1 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment MS_channel PF00924.13 EPA06874.1 - 0.1 11.8 5.1 0.085 12.1 0.9 2.3 2 0 0 2 2 2 0 Mechanosensitive ion channel Sec66 PF09802.4 EPA06876.1 - 0.017 14.5 0.1 0.02 14.3 0.1 1.0 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 Filament PF00038.16 EPA06876.1 - 0.018 14.5 1.0 0.019 14.4 0.7 1.0 1 0 0 1 1 1 0 Intermediate filament protein Myb_CC_LHEQLE PF14379.1 EPA06876.1 - 0.13 11.8 1.3 0.37 10.4 0.9 1.7 1 1 0 1 1 1 0 MYB-CC type transfactor, LHEQLE motif Phage_DsbA PF11126.3 EPA06876.1 - 0.29 11.2 1.7 0.57 10.3 0.1 1.9 1 1 1 2 2 2 0 Transcriptional regulator DsbA