# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Phos_pyr_kin PF08543.12 EPA04243.1 - 1.3e-72 244.2 0.7 2.2e-72 243.4 0.7 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase ThiP_synth PF10120.9 EPA04243.1 - 3.5e-55 186.1 0.0 7.4e-55 185.0 0.0 1.6 1 0 0 1 1 1 1 Thiamine-phosphate synthase PfkB PF00294.24 EPA04243.1 - 3.1e-10 39.9 0.0 4.9e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HTH_56 PF18662.1 EPA04243.1 - 5.2e-05 23.3 7.5 0.0017 18.4 0.5 3.4 3 0 0 3 3 3 2 Cch helix turn helix domain Carb_kinase PF01256.17 EPA04243.1 - 0.0021 17.6 0.1 0.0033 16.9 0.1 1.4 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 EPA04243.1 - 0.07 12.5 0.3 0.31 10.4 0.3 1.9 1 1 0 1 1 1 0 Hydroxyethylthiazole kinase family KH_5 PF13184.6 EPA04243.1 - 0.68 10.1 5.0 1.3 9.2 0.5 3.0 3 0 0 3 3 3 0 NusA-like KH domain HalOD2 PF18547.1 EPA04244.1 - 0.074 13.0 0.8 0.13 12.2 0.1 1.7 2 0 0 2 2 2 0 Halobacterial output domain 2 Ribo_biogen_C PF04034.13 EPA04245.1 - 6.1e-38 129.4 0.0 8.5e-38 129.0 0.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EPA04245.1 - 8.6e-07 28.7 0.1 1.3e-06 28.1 0.1 1.3 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI fn3 PF00041.21 EPA04248.1 - 9.5e-37 125.2 24.3 5e-14 52.4 5.0 4.2 4 0 0 4 4 4 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EPA04248.1 - 3.8e-06 27.4 26.5 0.012 16.2 0.7 4.8 3 1 1 4 4 4 3 Purple acid Phosphatase, N-terminal domain fn3_4 PF16794.5 EPA04248.1 - 6.8e-06 26.0 0.2 2.6 8.0 0.0 4.1 5 0 0 5 5 5 3 Fibronectin-III type domain SusE PF14292.6 EPA04248.1 - 0.002 18.4 26.5 0.0039 17.4 9.0 4.1 2 1 2 4 4 4 2 SusE outer membrane protein Interfer-bind PF09294.10 EPA04248.1 - 0.088 13.1 1.5 3.9 7.8 0.1 2.8 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III Fimbrillin_C PF15495.6 EPA04248.1 - 0.12 12.8 0.3 21 5.6 0.0 2.5 2 0 0 2 2 2 0 Major fimbrial subunit protein type IV, Fimbrillin, C-terminal PKD PF00801.20 EPA04248.1 - 0.27 11.1 25.0 0.22 11.4 0.7 4.6 2 2 2 4 4 4 0 PKD domain CopC PF04234.12 EPA04248.1 - 0.28 12.2 5.8 0.97 10.5 0.7 3.2 3 0 0 3 3 3 0 CopC domain EspB_PE PF18625.1 EPA04248.1 - 2 9.0 7.9 1.4 9.4 0.6 2.4 2 0 0 2 2 2 0 ESX-1 secreted protein B PE domain ALAD PF00490.21 EPA04249.1 - 2e-66 224.4 0.4 2.2e-66 224.2 0.4 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase GlutR_dimer PF00745.20 EPA04250.1 - 2.7e-05 24.5 0.0 3.1e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain Methyltransf_21 PF05050.12 EPA04252.1 - 1.2e-11 45.0 0.5 1.9e-11 44.3 0.5 1.4 1 1 0 1 1 1 1 Methyltransferase FkbM domain Spore_III_AF PF09581.10 EPA04253.1 - 0.00032 20.8 1.2 0.00049 20.2 1.2 1.2 1 0 0 1 1 1 1 Stage III sporulation protein AF (Spore_III_AF) Phlebovirus_NSM PF07246.11 EPA04253.1 - 0.055 12.8 1.2 0.075 12.4 1.2 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M BAAT_C PF08840.11 EPA04253.1 - 0.17 11.8 0.2 0.23 11.3 0.2 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Aminotran_1_2 PF00155.21 EPA04254.1 - 4.5e-41 141.2 0.0 5.7e-41 140.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II S-layer PF07752.11 EPA04254.1 - 0.039 13.0 0.1 0.079 12.0 0.1 1.5 1 0 0 1 1 1 0 S-layer protein HEAT_2 PF13646.6 EPA04255.1 - 1.3e-07 31.9 0.1 4.9e-06 26.9 0.0 2.7 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.22 EPA04255.1 - 0.065 13.5 0.1 21 5.7 0.0 3.2 4 0 0 4 4 4 0 HEAT repeat COQ9 PF08511.11 EPA04255.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 COQ9 TrmB PF01978.19 EPA04257.1 - 0.026 14.4 0.0 0.097 12.6 0.0 1.9 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Mga PF05043.13 EPA04257.1 - 0.17 12.5 2.0 1.2 9.8 0.1 2.6 3 0 0 3 3 3 0 Mga helix-turn-helix domain zf-trcl PF13451.6 EPA04258.1 - 0.012 15.5 0.4 0.85 9.6 0.0 2.2 2 0 0 2 2 2 0 Probable zinc-ribbon domain zf-FPG_IleRS PF06827.14 EPA04258.1 - 0.042 13.7 1.1 0.81 9.6 0.1 2.3 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf-RRPl_C4 PF17026.5 EPA04258.1 - 0.05 13.7 0.9 0.068 13.3 0.9 1.3 1 1 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type Lar_restr_allev PF14354.6 EPA04258.1 - 0.066 13.6 0.2 0.089 13.2 0.2 1.3 1 0 0 1 1 1 0 Restriction alleviation protein Lar DUF1297 PF06973.12 EPA04259.1 - 7.4e-12 45.2 0.1 7.7e-12 45.1 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) Peptidase_M50 PF02163.22 EPA04261.1 - 4.4e-19 68.7 1.1 9.4e-17 61.1 1.1 2.3 1 1 0 1 1 1 1 Peptidase family M50 PDZ_2 PF13180.6 EPA04261.1 - 3.7e-09 36.8 0.0 6.5e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EPA04261.1 - 6.7e-08 32.3 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EPA04261.1 - 0.00074 19.8 0.1 0.0016 18.8 0.1 1.5 1 0 0 1 1 1 1 PDZ domain ATP_bind_3 PF01171.20 EPA04262.1 - 2.6e-17 63.2 0.0 4e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.16 EPA04262.1 - 1.3e-05 24.2 0.0 1.7e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.13 EPA04262.1 - 0.0079 15.7 0.1 0.021 14.3 0.0 1.8 1 1 1 2 2 2 1 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 EPA04262.1 - 0.032 14.3 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family QueH PF02677.14 EPA04262.1 - 0.065 13.3 1.1 1.3 9.1 0.0 2.1 1 1 1 2 2 2 0 Epoxyqueuosine reductase QueH Response_reg PF00072.24 EPA04263.1 - 2e-25 89.1 3.1 2.2e-25 89.0 3.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain FleQ PF06490.11 EPA04263.1 - 0.015 15.7 0.2 0.035 14.5 0.2 1.8 1 1 0 1 1 1 0 Flagellar regulatory protein FleQ TrkA_N PF02254.18 EPA04263.1 - 0.028 14.7 1.7 0.051 13.8 1.7 1.5 1 1 0 1 1 1 0 TrkA-N domain DUF1944 PF09175.10 EPA04265.1 - 0.03 14.2 2.2 1.3 8.8 0.5 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1944) SpoVT_C PF15714.5 EPA04265.1 - 0.13 12.3 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Stage V sporulation protein T C-terminal, transcription factor HEPN_RES_NTD1 PF18870.1 EPA04265.1 - 0.23 11.7 5.5 0.57 10.4 0.4 2.3 1 1 1 2 2 2 0 HEPN/RES N-terminal domain 1 DNA_pol_E_B PF04042.16 EPA04266.1 - 9.1e-11 41.5 0.0 1.7e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Metallophos PF00149.28 EPA04266.1 - 1.1e-10 42.3 0.0 2.1e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase tRNA_anti-codon PF01336.25 EPA04266.1 - 0.064 13.2 0.1 0.15 12.1 0.1 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DUF1877 PF08974.10 EPA04266.1 - 0.072 13.2 0.3 0.73 9.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1877) DUF2326 PF10088.9 EPA04266.1 - 0.1 12.3 0.9 0.38 10.5 0.7 1.9 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2326) DNA_pol_D_N PF18018.1 EPA04266.1 - 0.11 12.6 0.2 0.26 11.4 0.0 1.9 2 1 0 2 2 2 0 DNA polymerase delta subunit OB-fold domain TP_methylase PF00590.20 EPA04267.1 - 2.3e-34 119.2 0.0 2.6e-34 119.0 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases SpoIIM PF01944.17 EPA04268.1 - 2.5e-08 34.1 8.0 3e-08 33.9 8.0 1.1 1 0 0 1 1 1 1 Stage II sporulation protein M Copper-bind PF00127.20 EPA04269.1 - 0.069 13.6 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family DUF1571 PF07608.11 EPA04269.1 - 0.18 11.2 0.0 0.26 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1571) Pro_isomerase PF00160.21 EPA04270.1 - 1.7e-50 171.4 0.3 3.4e-50 170.4 0.3 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Lpp-LpqN PF10738.9 EPA04270.1 - 0.04 13.4 0.1 0.14 11.6 0.1 1.9 1 1 0 1 1 1 0 Probable lipoprotein LpqN HHH_5 PF14520.6 EPA04273.1 - 7.3e-12 45.7 0.4 1.1e-11 45.1 0.4 1.2 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 EPA04273.1 - 2.2e-06 27.4 0.0 6.8e-06 25.8 0.0 1.8 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_2 PF12826.7 EPA04273.1 - 6e-06 26.3 0.0 2.3e-05 24.4 0.0 1.9 1 1 1 2 2 2 1 Helix-hairpin-helix motif HHH_8 PF14716.6 EPA04273.1 - 0.0018 18.6 0.1 0.11 12.8 0.1 2.3 1 1 1 2 2 2 2 Helix-hairpin-helix domain HHH PF00633.23 EPA04273.1 - 0.0068 16.2 0.0 0.077 12.9 0.0 2.8 3 0 0 3 3 3 1 Helix-hairpin-helix motif Cdd1 PF11731.8 EPA04273.1 - 0.024 14.9 0.1 0.22 11.8 0.0 2.1 1 1 1 2 2 2 0 Pathogenicity locus DUF4332 PF14229.6 EPA04273.1 - 0.033 14.4 0.0 0.066 13.5 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4332) RNA_pol_A_CTD PF03118.15 EPA04273.1 - 0.05 13.4 1.0 0.14 12.0 0.1 2.1 3 0 0 3 3 3 0 Bacterial RNA polymerase, alpha chain C terminal domain DUF2334 PF10096.9 EPA04274.1 - 4.6e-06 26.4 1.4 1.4e-05 24.9 1.1 2.1 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Polysacc_deac_1 PF01522.21 EPA04274.1 - 0.0011 18.8 0.0 0.0025 17.7 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase EPSP_synthase PF00275.20 EPA04275.1 - 2.8e-103 345.8 0.0 3.5e-103 345.5 0.0 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) HATPase_c PF02518.26 EPA04276.1 - 1.8e-15 57.4 0.6 3e-15 56.7 0.1 1.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 EPA04276.1 - 4.1e-07 29.8 0.2 9.7e-07 28.6 0.0 1.7 2 0 0 2 2 2 1 GHKL domain HATPase_c_2 PF13581.6 EPA04276.1 - 0.0052 16.7 0.0 0.0085 16.0 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain DUF3800 PF12686.7 EPA04276.1 - 0.15 12.7 2.2 0.23 12.1 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) Chorismate_synt PF01264.21 EPA04277.1 - 1.7e-15 56.6 0.0 1.8e-15 56.5 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase PAS_9 PF13426.7 EPA04278.1 - 5.4e-12 45.9 0.0 6.9e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 EPA04278.1 - 9.9e-09 35.4 0.0 1.5e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EPA04278.1 - 3.2e-08 33.8 0.0 4e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 EPA04278.1 - 2e-07 31.0 0.0 2.7e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EPA04278.1 - 7.9e-07 29.0 0.0 1.3e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_11 PF14598.6 EPA04278.1 - 0.018 15.2 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 PAS domain GHMP_kinases_N PF00288.26 EPA04279.1 - 1.1e-09 38.4 0.2 1.8e-09 37.7 0.2 1.3 1 0 0 1 1 1 1 GHMP kinases N terminal domain Aminotran_1_2 PF00155.21 EPA04280.1 - 6.9e-20 71.5 0.1 9.2e-20 71.1 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EPA04280.1 - 0.0064 15.8 0.0 0.0084 15.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EPA04280.1 - 0.0085 14.7 0.0 0.011 14.3 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme LemA PF04011.12 EPA04281.1 - 1.5e-48 164.5 0.1 1.9e-48 164.1 0.1 1.1 1 0 0 1 1 1 1 LemA family DUF4330 PF14221.6 EPA04281.1 - 0.0011 19.2 0.3 0.0017 18.6 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4330) ALIX_LYPXL_bnd PF13949.6 EPA04281.1 - 0.0022 17.4 1.1 0.0028 17.0 1.1 1.2 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV ACP_PD PF04336.12 EPA04281.1 - 0.0039 17.6 0.3 0.0056 17.1 0.3 1.3 1 0 0 1 1 1 1 Acyl carrier protein phosphodiesterase Chordopox_A13L PF05961.11 EPA04281.1 - 0.025 14.8 0.8 0.053 13.7 0.8 1.6 1 0 0 1 1 1 0 Chordopoxvirus A13L protein MacB_PCD PF12704.7 EPA04281.1 - 0.26 11.6 3.9 0.49 10.7 3.9 1.7 1 1 0 1 1 1 0 MacB-like periplasmic core domain SurA_N_2 PF13623.6 EPA04281.1 - 1.2 9.0 7.2 1.9 8.3 3.0 2.1 1 1 1 2 2 2 0 SurA N-terminal domain TackOD1 PF18551.1 EPA04282.1 - 4.2e-38 130.9 13.1 7.1e-38 130.2 13.1 1.3 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 Response_reg PF00072.24 EPA04282.1 - 1.6e-18 66.9 0.1 3.3e-18 65.9 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain zinc-ribbons_6 PF07191.12 EPA04282.1 - 0.0016 18.3 13.4 0.087 12.8 2.8 2.8 1 1 2 3 3 3 3 zinc-ribbons DZR PF12773.7 EPA04282.1 - 0.0081 16.2 10.8 0.4 10.8 4.3 2.6 1 1 1 2 2 2 2 Double zinc ribbon zf-Di19 PF05605.12 EPA04282.1 - 0.03 14.6 4.5 0.079 13.3 4.1 2.0 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding HCV_NS1 PF01560.17 EPA04282.1 - 0.037 12.7 1.5 0.055 12.1 1.5 1.1 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein E2/NS1 HypA PF01155.19 EPA04282.1 - 0.053 13.5 16.5 1 9.4 3.2 4.0 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DnaJ_CXXCXGXG PF00684.19 EPA04282.1 - 0.61 10.5 12.4 2.2 8.7 4.5 2.7 1 1 1 2 2 2 0 DnaJ central domain Spt4 PF06093.13 EPA04282.1 - 7.5 6.7 19.2 0.63 10.2 0.2 3.8 3 1 1 4 4 4 0 Spt4/RpoE2 zinc finger Aminotran_3 PF00202.21 EPA04283.1 - 1.4e-82 277.5 0.1 1.8e-82 277.2 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EPA04283.1 - 0.0001 21.7 0.0 0.00015 21.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EPA04283.1 - 0.056 12.6 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Aminotran_3 PF00202.21 EPA04285.1 - 1.5e-06 27.1 0.0 1.6e-06 27.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Thioredoxin_4 PF13462.6 EPA04286.1 - 1.4e-35 122.9 0.0 2e-35 122.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 EPA04286.1 - 4.5e-18 65.7 0.1 5.7e-17 62.1 0.1 2.0 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 EPA04286.1 - 3e-07 30.8 0.5 6e-07 29.9 0.5 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_5 PF13743.6 EPA04286.1 - 0.00072 19.3 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DUF5314 PF17241.2 EPA04286.1 - 0.028 14.1 0.0 0.053 13.2 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5314) Thioredoxin_8 PF13905.6 EPA04286.1 - 0.045 14.1 0.2 4.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like TraF PF13728.6 EPA04286.1 - 0.048 13.5 0.0 0.11 12.3 0.0 1.5 2 0 0 2 2 2 0 F plasmid transfer operon protein OTT_1508_deam PF14441.6 EPA04286.1 - 1.1 9.3 2.9 11 6.2 3.0 2.1 1 1 0 1 1 1 0 OTT_1508-like deaminase AAA_26 PF13500.6 EPA04287.1 - 5.2e-16 59.0 0.0 6e-16 58.9 0.0 1.0 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EPA04287.1 - 0.00012 22.1 0.0 0.00017 21.6 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Aminotran_1_2 PF00155.21 EPA04288.1 - 5.2e-21 75.2 0.0 5.7e-21 75.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II RuvC_1 PF18516.1 EPA04288.1 - 0.024 13.8 0.1 3.3 6.8 0.0 2.1 2 0 0 2 2 2 0 RuvC nuclease domain AAA_26 PF13500.6 EPA04289.1 - 8e-13 48.7 0.0 8.4e-13 48.6 0.0 1.0 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EPA04289.1 - 6.7e-05 22.9 0.0 6.7e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF1611 PF07755.11 EPA04289.1 - 0.062 12.6 0.1 0.062 12.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_C) P-loop domain ParA PF10609.9 EPA04289.1 - 0.073 12.5 0.0 0.073 12.5 0.0 1.1 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase TPM_phosphatase PF04536.14 EPA04290.1 - 3.6e-18 65.9 0.3 6e-18 65.2 0.3 1.3 1 1 0 1 1 1 1 TPM domain ETRAMP PF09716.10 EPA04290.1 - 0.076 13.1 0.0 0.1 12.6 0.0 1.3 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) HMG_CoA_synt_C PF08540.10 EPA04291.1 - 2.9e-32 112.4 0.1 6.6e-32 111.2 0.1 1.5 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EPA04291.1 - 2.5e-30 105.6 0.2 4e-30 105.0 0.2 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal TraT PF05818.12 EPA04293.1 - 3.2 7.4 3.5 3 7.5 3.5 1.0 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Radical_SAM PF04055.21 EPA04294.1 - 1.4e-17 64.6 0.4 3.2e-17 63.4 0.3 1.6 2 0 0 2 2 2 1 Radical SAM superfamily BATS PF06968.13 EPA04294.1 - 1.6e-12 47.4 0.0 3.2e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain DUF1743 PF08489.11 EPA04295.1 - 9.9e-12 45.0 0.0 1.1e-11 44.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1743) DUF1743 PF08489.11 EPA04297.1 - 7.6e-09 35.6 0.1 8.5e-09 35.5 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1743) UPF0147 PF03685.13 EPA04298.1 - 4.9e-31 106.6 2.1 5.6e-31 106.4 2.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0147) UPF0253 PF06786.12 EPA04298.1 - 0.0028 17.9 0.0 0.64 10.3 0.0 2.3 1 1 0 2 2 2 2 Uncharacterised protein family (UPF0253) PPDK_N PF01326.19 EPA04298.1 - 0.055 12.7 0.2 0.067 12.5 0.2 1.3 1 1 0 1 1 1 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain Glyco_hydro_20b PF02838.15 EPA04298.1 - 0.081 13.7 0.4 0.096 13.5 0.4 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 CUTL PF16557.5 EPA04298.1 - 0.14 12.3 0.3 0.84 9.9 0.1 2.1 1 1 1 2 2 2 0 CUT1-like DNA-binding domain of SATB Rieske PF00355.26 EPA04299.1 - 2.9e-18 65.6 0.1 3.6e-18 65.3 0.1 1.0 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 EPA04299.1 - 6.8e-08 32.4 0.0 8.2e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain tRNA-synt_1c PF00749.21 EPA04300.1 - 1.6e-78 263.8 0.0 2.9e-78 262.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EPA04300.1 - 3e-22 79.3 0.1 6.4e-22 78.3 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain FAA_hydrolase PF01557.18 EPA04301.1 - 1.3e-69 234.2 0.0 1.7e-69 233.8 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF2437 PF10370.9 EPA04301.1 - 0.0021 18.9 0.0 0.0056 17.5 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF2437) Methyltransf_25 PF13649.6 EPA04302.1 - 1.6e-06 28.7 0.0 2.4e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA04302.1 - 2.4e-05 24.2 0.1 4.4e-05 23.3 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EPA04302.1 - 3.9e-05 23.3 0.0 5.7e-05 22.7 0.0 1.2 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_11 PF08241.12 EPA04302.1 - 5.4e-05 23.8 0.0 0.00013 22.6 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_5 PF01795.19 EPA04302.1 - 0.0016 18.0 0.0 0.002 17.7 0.0 1.1 1 0 0 1 1 1 1 MraW methylase family Methyltransf_12 PF08242.12 EPA04302.1 - 0.0044 17.7 0.0 0.0065 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EPA04302.1 - 0.0083 15.6 0.2 0.0093 15.4 0.2 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB CMAS PF02353.20 EPA04302.1 - 0.0092 15.3 0.0 0.011 15.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 EPA04302.1 - 0.023 14.2 0.0 0.026 14.1 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase small domain PA-IIL PF07472.11 EPA04302.1 - 0.046 14.0 0.1 0.047 14.0 0.1 1.2 1 1 0 1 1 1 0 Fucose-binding lectin II (PA-IIL) TrkA_N PF02254.18 EPA04302.1 - 0.073 13.3 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain Methyltransf_18 PF12847.7 EPA04302.1 - 0.074 13.0 0.0 0.095 12.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Acetyltransf_1 PF00583.25 EPA04303.1 - 1.6e-06 28.3 0.0 3.4e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EPA04303.1 - 5.3e-05 23.2 0.0 0.00021 21.2 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EPA04303.1 - 8.7e-05 22.4 0.0 0.00019 21.3 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EPA04303.1 - 0.00062 20.1 0.0 0.0013 19.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EPA04303.1 - 0.0019 17.8 1.2 0.033 13.8 0.1 2.2 2 0 0 2 2 2 1 GNAT acetyltransferase Acetyltransf_3 PF13302.7 EPA04303.1 - 0.0033 18.1 0.0 0.0057 17.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PABP PF00658.18 EPA04303.1 - 0.02 15.1 0.3 0.098 12.9 0.0 2.2 2 0 0 2 2 2 0 Poly-adenylate binding protein, unique domain Acetyltransf_9 PF13527.7 EPA04303.1 - 0.073 13.2 0.0 0.49 10.5 0.0 2.3 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Gly_acyl_tr_C PF08444.10 EPA04303.1 - 0.077 13.2 0.7 0.26 11.6 0.1 2.1 2 0 0 2 2 2 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region ALAD PF00490.21 EPA04304.1 - 6.8e-64 216.0 1.0 7.5e-64 215.9 1.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase DUF2674 PF10879.8 EPA04304.1 - 0.053 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2674) AtuA PF07287.11 EPA04304.1 - 0.084 11.6 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Acyclic terpene utilisation family protein AtuA SH3_6 PF12913.7 EPA04304.1 - 0.097 12.2 0.1 0.24 11.0 0.1 1.7 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) DUF1896 PF08989.10 EPA04305.1 - 0.021 14.9 0.6 0.026 14.6 0.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1896) DUF2833 PF11090.8 EPA04305.1 - 0.027 14.8 2.2 0.034 14.5 0.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2833) IMS PF00817.20 EPA04305.1 - 0.03 14.3 0.1 0.03 14.3 0.1 1.1 1 0 0 1 1 1 0 impB/mucB/samB family JmjN PF02375.17 EPA04305.1 - 0.17 11.8 2.7 1 9.4 0.2 2.4 1 1 1 2 2 2 0 jmjN domain DNA_pol3_delta2 PF13177.6 EPA04306.1 - 1e-16 61.2 0.2 8.2e-13 48.4 0.2 2.5 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 EPA04306.1 - 7.7e-13 49.0 1.0 1.4e-12 48.2 0.1 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EPA04306.1 - 7.6e-11 42.3 1.5 1.3e-10 41.6 0.5 1.9 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta PF06144.13 EPA04306.1 - 5.3e-05 23.1 0.2 0.00014 21.7 0.2 1.7 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 EPA04306.1 - 6.2e-05 23.4 0.1 0.00026 21.4 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EPA04306.1 - 0.00012 21.9 0.0 0.00033 20.4 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EPA04306.1 - 0.00032 21.0 1.1 0.11 12.7 0.0 2.6 1 1 1 2 2 2 2 AAA domain Rad17 PF03215.15 EPA04306.1 - 0.00036 20.5 0.1 0.0035 17.3 0.0 2.4 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EPA04306.1 - 0.0004 20.7 0.1 0.00099 19.4 0.1 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA_3 PF07726.11 EPA04306.1 - 0.00042 20.2 0.0 0.0008 19.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EPA04306.1 - 0.0041 16.6 0.0 0.55 9.6 0.0 2.5 2 0 0 2 2 2 1 Bacterial TniB protein ResIII PF04851.15 EPA04306.1 - 0.0055 16.7 0.2 0.19 11.7 0.0 2.4 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 EPA04306.1 - 0.0072 15.7 0.0 0.55 9.6 0.0 2.6 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI PTPlike_phytase PF14566.6 EPA04306.1 - 0.0079 16.3 0.2 0.066 13.3 0.0 2.2 2 0 0 2 2 2 1 Inositol hexakisphosphate PhoH PF02562.16 EPA04306.1 - 0.02 14.3 0.2 2.6 7.4 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein DEAD PF00270.29 EPA04306.1 - 0.026 14.3 0.9 1.4 8.7 0.1 2.7 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_24 PF13479.6 EPA04306.1 - 0.044 13.5 2.0 1.1 8.9 2.0 2.4 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 EPA04306.1 - 0.063 12.3 0.1 0.82 8.7 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_5 PF07728.14 EPA04306.1 - 0.12 12.4 0.6 1.2 9.1 0.6 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EPA04306.1 - 0.17 12.2 1.1 2.6 8.4 0.5 2.7 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.17 EPA04306.1 - 0.64 10.1 4.9 14 5.7 4.8 2.2 1 1 0 1 1 1 0 Helicase HerA, central domain DEAD PF00270.29 EPA04307.1 - 8.6e-14 51.7 0.0 1e-13 51.5 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EPA04307.1 - 1.9e-05 24.8 0.0 2.3e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EPA04307.1 - 0.001 18.2 0.0 0.0011 18.1 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein ATPase_2 PF01637.18 EPA04307.1 - 0.036 14.0 0.0 0.048 13.6 0.0 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EPA04307.1 - 0.054 13.1 0.0 0.065 12.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EPA04307.1 - 0.17 11.3 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 PhoH-like protein Helicase_C PF00271.31 EPA04308.1 - 8.4e-12 45.4 0.6 2.5e-10 40.7 0.2 2.8 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EPA04308.1 - 1.3e-07 31.5 0.1 3.5e-07 30.2 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase MCM PF00493.23 EPA04309.1 - 4.3e-94 313.8 0.0 6.2e-94 313.3 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EPA04309.1 - 1.6e-35 121.7 0.1 2.8e-35 120.9 0.1 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EPA04309.1 - 1.8e-23 82.8 1.3 3.7e-23 81.8 1.3 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EPA04309.1 - 7.4e-10 39.4 2.0 1.1e-09 38.8 0.3 2.1 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.14 EPA04309.1 - 1.6e-06 28.2 0.0 2.3e-05 24.4 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EPA04309.1 - 2.8e-06 26.9 0.0 0.0002 20.8 0.0 2.5 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EPA04309.1 - 0.00081 19.3 0.0 0.0026 17.6 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EPA04309.1 - 0.075 12.7 0.2 0.18 11.5 0.2 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EPA04309.1 - 0.17 12.3 0.7 4.8 7.5 0.0 3.0 3 1 0 4 4 4 0 AAA ATPase domain HATPase_c PF02518.26 EPA04310.1 - 6.2e-22 78.2 0.4 4.3e-21 75.5 0.1 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PorA PF11271.8 EPA04310.1 - 1e-10 41.4 0.0 1.6e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Porin PorA HisKA PF00512.25 EPA04310.1 - 1.4e-09 37.8 0.1 3.4e-09 36.6 0.1 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EPA04310.1 - 1.8e-08 34.2 0.6 1.1e-07 31.7 0.0 2.4 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 EPA04310.1 - 2.8e-05 23.9 0.3 7.2e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EPA04310.1 - 0.0067 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain PspB PF06667.12 EPA04310.1 - 0.28 11.3 1.4 0.34 11.0 0.1 1.8 2 0 0 2 2 2 0 Phage shock protein B Fer4 PF00037.27 EPA04311.1 - 2.4e-09 36.6 8.2 0.00023 20.8 2.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 EPA04311.1 - 3e-08 33.7 5.2 1.8e-07 31.2 5.8 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 EPA04311.1 - 4.2e-08 33.7 15.7 5.8e-06 26.8 9.8 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 EPA04311.1 - 5.3e-08 32.9 4.5 0.0016 18.6 0.8 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 EPA04311.1 - 7.1e-08 32.8 12.1 5.8e-07 29.9 5.9 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 EPA04311.1 - 1.1e-06 29.5 5.5 2.5e-06 28.3 5.6 1.6 1 1 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 EPA04311.1 - 2.2e-06 27.7 7.2 2e-05 24.7 7.5 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EPA04311.1 - 6.9e-06 25.9 9.6 0.019 15.0 0.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EPA04311.1 - 5e-05 23.8 4.2 0.00014 22.3 4.5 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 EPA04311.1 - 0.00013 21.8 11.0 0.0034 17.4 0.9 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_18 PF13746.6 EPA04311.1 - 0.0014 18.8 8.8 0.011 15.9 6.5 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 EPA04311.1 - 0.0015 18.9 8.3 0.27 11.9 0.3 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 EPA04311.1 - 0.003 18.1 9.3 0.12 13.0 0.3 2.6 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_22 PF17179.4 EPA04311.1 - 0.0047 17.7 0.5 3.6 8.5 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 EPA04311.1 - 0.28 12.2 13.7 3.2 8.9 5.1 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_15 PF13459.6 EPA04311.1 - 2.7 8.8 12.3 0.34 11.7 1.3 2.7 3 1 0 3 3 2 0 4Fe-4S single cluster domain Sld5 PF05916.11 EPA04312.1 - 4.3e-09 36.8 1.1 6.3e-09 36.3 1.1 1.2 1 0 0 1 1 1 1 GINS complex protein DUF620 PF04788.12 EPA04312.1 - 0.025 14.0 0.2 0.07 12.5 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF620) EamA PF00892.20 EPA04314.1 - 2.1e-15 57.1 14.4 2.3e-15 56.9 14.4 1.0 1 0 0 1 1 1 1 EamA-like transporter family TPT PF03151.16 EPA04314.1 - 0.0045 16.4 4.7 0.0052 16.2 4.7 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family ATP_bind_1 PF03029.17 EPA04314.1 - 0.055 13.3 0.0 0.074 12.8 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Ery_res_leader1 PF08051.11 EPA04314.1 - 0.19 11.9 1.5 1.9 8.8 0.2 2.9 2 0 0 2 2 2 0 Erythromycin resistance leader peptide Response_reg PF00072.24 EPA04315.1 - 2.5e-25 88.8 0.8 2.8e-25 88.7 0.8 1.0 1 0 0 1 1 1 1 Response regulator receiver domain 2-Hacid_dh_C PF02826.19 EPA04315.1 - 0.0037 16.7 0.0 0.0044 16.4 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF2183 PF09949.9 EPA04315.1 - 0.07 13.5 0.1 1.8 8.9 0.0 2.2 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2183) DUF1647 PF07801.11 EPA04315.1 - 0.12 12.1 0.1 0.16 11.7 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1647) Peptidase_S24 PF00717.23 EPA04318.1 - 2e-09 37.2 0.4 3.8e-09 36.4 0.4 1.4 1 0 0 1 1 1 1 Peptidase S24-like Pho88 PF10032.9 EPA04318.1 - 0.013 14.8 0.8 0.013 14.8 0.8 1.9 1 1 1 2 2 2 0 Phosphate transport (Pho88) DUF202 PF02656.15 EPA04318.1 - 0.12 12.8 4.4 4.6 7.8 0.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF202) DUF1129 PF06570.11 EPA04318.1 - 0.14 11.7 11.1 0.72 9.3 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) TctB PF07331.11 EPA04318.1 - 0.47 10.7 12.5 1.5 9.1 3.4 3.0 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter TctB family EamA PF00892.20 EPA04319.1 - 0.0036 17.5 0.1 0.0041 17.3 0.1 1.1 1 0 0 1 1 1 1 EamA-like transporter family Sar8_2 PF03058.14 EPA04321.1 - 0.067 13.8 0.0 0.1 13.1 0.0 1.4 1 0 0 1 1 1 0 Sar8.2 family DciA PF05258.12 EPA04321.1 - 0.2 12.0 0.0 0.31 11.4 0.0 1.3 1 0 0 1 1 1 0 Dna[CI] antecedent, DciA DUF4352 PF11611.8 EPA04322.1 - 0.032 14.5 0.3 0.045 14.0 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4352) Tmemb_cc2 PF10267.9 EPA04322.1 - 0.073 12.2 0.2 0.08 12.1 0.2 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Thioredoxin_4 PF13462.6 EPA04323.1 - 2.3e-34 119.0 0.0 2.8e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 EPA04323.1 - 2.4e-12 47.0 0.1 4.7e-11 42.8 0.1 2.1 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 EPA04323.1 - 7e-09 36.1 0.0 1e-08 35.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_5 PF13743.6 EPA04323.1 - 0.009 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EPA04323.1 - 0.03 14.6 0.1 8.3 6.8 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin-like Voltage_CLC PF00654.20 EPA04323.1 - 0.17 11.1 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Voltage gated chloride channel eIF-5a PF01287.20 EPA04325.1 - 3e-07 30.4 0.8 4.3e-07 29.9 0.8 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EPA04325.1 - 5.8e-05 23.0 0.1 0.0089 16.0 0.0 2.3 2 0 0 2 2 2 2 Elongation factor P (EF-P) KOW-like domain CBS PF00571.28 EPA04326.1 - 3.8e-08 33.6 1.0 0.078 13.4 0.0 4.3 4 1 0 4 4 4 3 CBS domain DHFR_1 PF00186.19 EPA04326.1 - 0.056 13.1 0.1 0.55 9.9 0.0 2.2 1 1 1 2 2 2 0 Dihydrofolate reductase DUF5049 PF16468.5 EPA04326.1 - 0.11 12.5 0.1 0.28 11.1 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5049) ABC_tran PF00005.27 EPA04327.1 - 1e-11 45.5 0.0 1.1e-11 45.5 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EPA04327.1 - 0.00012 21.8 0.1 0.00017 21.3 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 EPA04327.1 - 0.00071 19.8 0.0 0.00082 19.5 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EPA04327.1 - 0.0024 17.5 0.0 0.0024 17.5 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_27 PF13514.6 EPA04327.1 - 0.0027 17.4 0.0 0.0034 17.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 EPA04327.1 - 0.0036 16.8 0.1 0.0045 16.5 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EPA04327.1 - 0.0045 16.8 0.0 0.0047 16.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EPA04327.1 - 0.0084 16.6 0.2 0.011 16.3 0.2 1.2 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EPA04327.1 - 0.015 15.0 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EPA04327.1 - 0.021 14.7 0.0 0.024 14.6 0.0 1.1 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 EPA04327.1 - 0.029 14.9 0.0 0.039 14.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EPA04327.1 - 0.041 13.9 0.0 0.052 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EPA04327.1 - 0.043 14.2 0.0 0.043 14.2 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 EPA04327.1 - 0.047 13.9 0.0 0.051 13.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EPA04327.1 - 0.053 13.4 0.0 0.063 13.2 0.0 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EPA04327.1 - 0.054 13.8 0.0 0.061 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EPA04327.1 - 0.064 13.7 0.0 0.081 13.3 0.0 1.2 1 0 0 1 1 1 0 RNA helicase T2SSE PF00437.20 EPA04327.1 - 0.069 12.2 0.0 0.075 12.1 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_17 PF13207.6 EPA04327.1 - 0.073 13.5 0.0 0.097 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EPA04327.1 - 0.093 12.4 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase MeaB PF03308.16 EPA04327.1 - 0.098 11.6 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 EPA04327.1 - 0.15 11.8 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 EPA04327.1 - 0.19 10.9 0.1 0.2 10.8 0.1 1.1 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 EPA04327.1 - 0.19 11.7 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 NACHT domain ABC_ATPase PF09818.9 EPA04327.1 - 0.24 10.1 0.1 0.27 10.0 0.1 1.0 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_13 PF13166.6 EPA04327.1 - 0.29 9.7 0.0 0.29 9.7 0.0 1.0 1 0 0 1 1 1 0 AAA domain APG5 PF04106.12 EPA04328.1 - 0.056 13.0 2.8 0.058 13.0 2.8 1.0 1 0 0 1 1 1 0 Autophagy protein Apg5 FCH PF00611.23 EPA04328.1 - 0.065 13.5 3.0 0.091 13.1 3.0 1.3 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain CSD PF00313.22 EPA04330.1 - 2.1e-21 75.6 3.4 2.5e-21 75.3 3.4 1.1 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 EPA04330.1 - 2.2e-06 27.3 0.7 2.2e-06 27.2 0.7 1.1 1 0 0 1 1 1 1 Ribonuclease B OB domain Gar1 PF04410.14 EPA04331.1 - 3.6e-05 23.6 0.0 3.9e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region DUF782 PF05614.11 EPA04331.1 - 0.099 13.0 0.0 0.11 13.0 0.0 1.1 1 0 0 1 1 1 0 Circovirus protein of unknown function (DUF782) eIF-1a PF01176.19 EPA04332.1 - 4e-19 68.2 1.7 5.3e-19 67.8 1.7 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myosin_N PF02736.19 EPA04332.1 - 0.009 15.8 1.2 0.57 10.1 0.1 2.5 2 0 0 2 2 2 2 Myosin N-terminal SH3-like domain CxxCxxCC PF03692.15 EPA04333.1 - 1.6e-10 41.5 0.3 3.5e-10 40.4 0.3 1.6 1 1 0 1 1 1 1 Putative zinc- or iron-chelating domain fn3 PF00041.21 EPA04334.1 - 0.001 19.4 0.1 0.0025 18.1 0.1 1.6 2 0 0 2 2 2 1 Fibronectin type III domain DUF1411 PF07199.11 EPA04334.1 - 0.077 12.6 0.1 0.15 11.7 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1411) HTH_24 PF13412.6 EPA04335.1 - 7.6e-10 38.2 2.0 4.4e-05 23.0 0.2 2.4 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 EPA04335.1 - 1.9e-09 37.2 1.5 1.4e-08 34.4 0.9 2.5 2 1 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_12 PF08461.10 EPA04335.1 - 1.9e-07 30.9 0.9 2.9e-07 30.3 0.3 1.6 2 0 0 2 2 2 1 Ribonuclease R winged-helix domain HTH_11 PF08279.12 EPA04335.1 - 1.4e-06 28.2 0.6 5.8e-06 26.1 0.6 2.1 1 1 0 1 1 1 1 HTH domain Penicillinase_R PF03965.16 EPA04335.1 - 6.8e-05 23.2 0.3 0.00036 20.8 0.0 2.0 2 0 0 2 2 2 1 Penicillinase repressor HTH_Tnp_Tc3_2 PF01498.18 EPA04335.1 - 0.00013 22.1 1.5 0.00021 21.5 0.1 2.0 3 0 0 3 3 3 1 Transposase HTH_20 PF12840.7 EPA04335.1 - 0.00017 21.6 0.0 0.00025 21.0 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_DeoR PF08220.12 EPA04335.1 - 0.003 17.3 0.1 0.011 15.5 0.1 2.0 1 1 0 1 1 1 1 DeoR-like helix-turn-helix domain Myb_DNA-bind_4 PF13837.6 EPA04335.1 - 0.011 16.0 0.1 0.028 14.8 0.0 1.7 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF3658 PF12395.8 EPA04335.1 - 0.016 15.1 0.3 0.047 13.6 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function HTH_32 PF13565.6 EPA04335.1 - 0.021 15.4 0.0 0.04 14.5 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain FUR PF01475.19 EPA04335.1 - 0.026 14.7 0.1 0.056 13.6 0.0 1.5 2 0 0 2 2 2 0 Ferric uptake regulator family Arg_repressor PF01316.21 EPA04335.1 - 0.04 13.7 0.3 0.1 12.4 0.3 1.7 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain RNA_binding PF01877.17 EPA04335.1 - 0.042 14.1 2.0 0.084 13.2 0.4 1.9 2 0 0 2 2 2 0 RNA binding Nuc_N PF14448.6 EPA04335.1 - 0.049 13.5 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Nuclease N terminal DUF3783 PF12646.7 EPA04335.1 - 0.053 13.5 0.0 0.26 11.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3783) HU-DNA_bdg PF14848.6 EPA04335.1 - 0.067 13.2 2.4 0.23 11.4 0.1 2.2 2 0 0 2 2 2 0 DNA-binding domain Sigma70_r4_2 PF08281.12 EPA04335.1 - 0.08 12.6 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 PepSY_like PF11396.8 EPA04335.1 - 9.5 6.8 8.3 4.8 7.8 1.0 2.9 1 1 2 3 3 3 0 Putative beta-lactamase-inhibitor-like, PepSY-like ADH_N PF08240.12 EPA04336.1 - 1.1e-33 115.4 0.9 1.7e-33 114.7 0.9 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EPA04336.1 - 1.3e-27 96.4 0.2 2.1e-27 95.7 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EPA04336.1 - 5.2e-13 50.2 0.0 7.8e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EPA04336.1 - 5.3e-08 32.6 0.1 1.3e-07 31.4 0.1 1.5 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus PglD_N PF17836.1 EPA04336.1 - 0.002 18.8 2.1 0.0042 17.7 2.1 1.6 1 0 0 1 1 1 1 PglD N-terminal domain AlaDh_PNT_C PF01262.21 EPA04336.1 - 0.0075 15.6 0.2 0.012 14.9 0.2 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 EPA04336.1 - 0.018 15.3 0.2 0.039 14.2 0.1 1.6 2 0 0 2 2 2 0 TrkA-N domain DapB_N PF01113.20 EPA04336.1 - 0.032 14.4 0.3 0.06 13.5 0.3 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus TFIIB PF00382.19 EPA04337.1 - 9.1e-25 86.5 2.3 2.1e-12 46.9 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EPA04337.1 - 6.5e-09 35.2 1.2 6.5e-09 35.2 1.2 1.8 2 0 0 2 2 2 1 TFIIB zinc-binding RPA_interact_C PF14768.6 EPA04337.1 - 0.014 15.9 2.2 1.1 9.9 2.2 2.8 1 1 0 1 1 1 0 Replication protein A interacting C-terminal Auto_anti-p27 PF06677.12 EPA04337.1 - 0.05 13.8 0.4 0.05 13.8 0.4 2.1 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF2318 PF10080.9 EPA04337.1 - 0.1 12.7 4.1 6.1 7.0 0.2 2.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) zinc-ribbons_6 PF07191.12 EPA04337.1 - 0.33 11.0 3.8 1 9.4 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbons DZR PF12773.7 EPA04337.1 - 0.54 10.3 4.1 0.31 11.1 0.3 2.2 2 0 0 2 2 2 0 Double zinc ribbon SMC_ScpA PF02616.14 EPA04338.1 - 3.3e-06 27.2 0.8 0.02 14.8 0.0 2.1 2 0 0 2 2 2 2 Segregation and condensation protein ScpA SRP19 PF01922.17 EPA04339.1 - 4.2e-12 46.8 0.1 5.3e-12 46.5 0.1 1.1 1 0 0 1 1 1 1 SRP19 protein PX PF00787.24 EPA04340.1 - 0.032 14.2 0.0 0.032 14.2 0.0 1.2 1 0 0 1 1 1 0 PX domain SMC_ScpB PF04079.16 EPA04341.1 - 8.5e-36 123.0 0.6 1e-35 122.7 0.6 1.1 1 0 0 1 1 1 1 Segregation and condensation complex subunit ScpB PadR PF03551.14 EPA04341.1 - 0.027 14.4 0.4 0.91 9.5 0.1 2.3 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family HHH_3 PF12836.7 EPA04341.1 - 0.041 14.1 0.0 0.095 13.0 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif HTH_20 PF12840.7 EPA04341.1 - 0.11 12.6 0.0 0.36 10.9 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain CorA PF01544.18 EPA04342.1 - 1.3e-69 234.7 5.3 1.3e-69 234.7 5.3 1.9 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein Tetraspanin PF00335.20 EPA04342.1 - 0.014 15.2 1.2 0.014 15.2 1.2 2.4 2 0 0 2 2 2 0 Tetraspanin family Herpes_UL92 PF03048.14 EPA04342.1 - 0.029 14.2 2.6 0.035 13.9 0.3 2.3 2 1 0 2 2 2 0 UL92 family T2SSF PF00482.23 EPA04342.1 - 0.58 10.1 0.0 0.58 10.1 0.0 3.3 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F Ribosomal_S8e PF01201.22 EPA04343.1 - 5e-23 81.8 5.4 5.8e-23 81.6 5.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e Response_reg PF00072.24 EPA04345.1 - 2.3e-18 66.4 0.4 3.6e-18 65.7 0.4 1.3 1 0 0 1 1 1 1 Response regulator receiver domain TPR_2 PF07719.17 EPA04345.1 - 0.0041 17.1 0.1 0.2 11.8 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat Rhodanese PF00581.20 EPA04345.1 - 0.01 16.4 0.0 0.057 14.0 0.0 2.2 2 1 0 2 2 2 0 Rhodanese-like domain TPR_1 PF00515.28 EPA04345.1 - 0.032 14.1 0.0 0.097 12.5 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat PK_C PF02887.16 EPA04345.1 - 0.039 14.2 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 Pyruvate kinase, alpha/beta domain TPR_8 PF13181.6 EPA04345.1 - 0.07 13.4 1.4 0.33 11.3 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat NFACT-R_2 PF18297.1 EPA04345.1 - 0.13 12.5 0.9 0.86 9.8 0.1 2.4 3 0 0 3 3 3 0 NFACT protein RNA binding domain TPR_6 PF13174.6 EPA04345.1 - 0.14 12.9 0.2 5.6 7.8 0.0 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF4829 PF16111.5 EPA04345.1 - 0.19 12.5 1.7 0.41 11.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4829) SMC_N PF02463.19 EPA04345.1 - 0.19 11.1 1.0 0.35 10.3 0.5 2.0 1 1 1 2 2 2 0 RecF/RecN/SMC N terminal domain CbiG_N PF11760.8 EPA04346.1 - 4e-33 113.3 0.2 6.4e-33 112.6 0.2 1.3 1 0 0 1 1 1 1 Cobalamin synthesis G N-terminal CbiG_C PF01890.16 EPA04346.1 - 4.4e-25 88.5 0.1 3.4e-24 85.7 0.0 2.0 2 0 0 2 2 2 1 Cobalamin synthesis G C-terminus CbiG_mid PF11761.8 EPA04346.1 - 2.3e-14 53.3 0.0 5.5e-14 52.1 0.0 1.7 1 0 0 1 1 1 1 Cobalamin biosynthesis central region CbiX PF01903.17 EPA04347.1 - 2.5e-16 59.9 0.0 2.7e-16 59.8 0.0 1.0 1 0 0 1 1 1 1 CbiX Trp_halogenase PF04820.14 EPA04348.1 - 1.9e-06 27.1 0.0 6.7e-06 25.2 0.0 1.7 1 1 0 1 1 1 1 Tryptophan halogenase Transket_pyr PF02779.24 EPA04349.1 - 7.8e-11 42.0 0.0 8e-11 41.9 0.0 1.0 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Ribul_P_3_epim PF00834.19 EPA04350.1 - 3.4e-12 46.2 0.0 5.2e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family DUF3939 PF13075.6 EPA04350.1 - 0.17 11.9 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) HATPase_c PF02518.26 EPA04351.1 - 6.9e-23 81.3 1.1 1.6e-22 80.1 1.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MEDS PF14417.6 EPA04351.1 - 1e-12 48.2 0.0 1.7e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain HisKA PF00512.25 EPA04351.1 - 4.4e-12 45.9 0.0 1.3e-11 44.4 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EPA04351.1 - 2.4e-07 30.6 1.1 2.4e-07 30.6 1.1 1.9 2 0 0 2 2 2 1 GHKL domain Cdc13_OB2 PF18691.1 EPA04351.1 - 0.0083 16.2 6.6 0.017 15.1 0.8 3.2 2 1 1 3 3 3 1 Cell division control protein 13, OB2 domain Sigma70_r1_1 PF03979.14 EPA04351.1 - 0.014 15.4 0.2 0.049 13.7 0.2 2.0 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 HATPase_c_2 PF13581.6 EPA04351.1 - 0.015 15.3 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain tRNA-synt_His PF13393.6 EPA04351.1 - 0.094 12.0 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 Histidyl-tRNA synthetase Cyc-maltodext_N PF09087.11 EPA04351.1 - 0.1 12.9 1.1 18 5.7 0.1 3.0 2 1 1 3 3 3 0 Cyclomaltodextrinase, N-terminal HATPase_c_3 PF13589.6 EPA04351.1 - 0.11 12.3 1.9 0.53 10.1 1.9 2.2 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MLIP PF15274.6 EPA04351.1 - 0.12 12.2 0.2 0.2 11.6 0.2 1.4 1 0 0 1 1 1 0 Muscular LMNA-interacting protein BRCT PF00533.26 EPA04351.1 - 0.64 10.4 4.4 2 8.9 0.1 3.2 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain DUF3800 PF12686.7 EPA04351.1 - 2.6 8.7 8.7 0.095 13.3 1.1 2.3 2 2 0 2 2 2 0 Protein of unknown function (DUF3800) Yippee-Mis18 PF03226.14 EPA04353.1 - 0.00031 20.9 0.5 0.00043 20.5 0.5 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EPA04353.1 - 0.0034 17.6 0.3 0.0061 16.8 0.3 1.4 1 0 0 1 1 1 1 C-terminal domain of RIG-I DUF4371 PF14291.6 EPA04353.1 - 0.08 12.6 0.1 0.11 12.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) LDcluster4 PF18306.1 EPA04354.1 - 2.7e-26 92.1 0.8 2.9e-26 91.9 0.8 1.0 1 0 0 1 1 1 1 SLOG cluster4 family DNA_processg_A PF02481.15 EPA04354.1 - 0.00075 18.8 0.1 0.00083 18.7 0.1 1.1 1 0 0 1 1 1 1 DNA recombination-mediator protein A HIT PF01230.23 EPA04355.1 - 1.3e-22 80.3 0.6 1.7e-22 80.0 0.6 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EPA04355.1 - 1.8e-12 47.7 0.1 2.4e-12 47.3 0.1 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EPA04355.1 - 0.0011 18.8 0.2 0.0015 18.4 0.2 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 GalP_UDP_tr_C PF02744.17 EPA04355.1 - 0.0088 15.8 0.1 0.011 15.4 0.1 1.2 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain zf-C4pol PF14260.6 EPA04356.1 - 0.021 15.3 7.2 0.75 10.3 0.8 2.2 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta HNH_5 PF14279.6 EPA04356.1 - 0.076 12.9 11.4 1.5 8.7 0.1 3.5 3 1 1 4 4 4 0 HNH endonuclease Cytochrome_C7 PF14522.6 EPA04356.1 - 0.31 11.1 10.5 0.81 9.7 5.0 2.2 1 1 0 2 2 2 0 Cytochrome c7 and related cytochrome c DUF4428 PF14471.6 EPA04356.1 - 2 8.4 15.9 2.3 8.2 0.7 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4428) Prok-RING_4 PF14447.6 EPA04356.1 - 3.6 7.5 12.2 0.87 9.5 0.5 3.5 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 Cytochrom_c3_2 PF14537.6 EPA04356.1 - 4.7 7.8 11.3 1.7e+02 2.8 11.3 2.7 1 1 0 1 1 1 0 Cytochrome c3 3HCDH_N PF02737.18 EPA04357.1 - 6.4e-66 221.7 0.6 6.4e-66 221.7 0.6 1.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EPA04357.1 - 9e-34 116.0 0.2 1.4e-26 93.0 0.1 2.8 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_Gly3P_dh_N PF01210.23 EPA04357.1 - 4.2e-05 23.6 0.1 7.4e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 EPA04357.1 - 0.00013 22.2 0.1 0.00023 21.4 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EPA04357.1 - 0.054 14.1 1.3 0.2 12.2 1.3 2.1 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 EPA04357.1 - 0.3 10.7 3.4 20 4.7 3.4 2.3 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain DUF643 PF04867.12 EPA04357.1 - 1.4 9.6 6.9 0.41 11.3 0.6 2.9 3 1 1 4 4 4 0 Protein of unknown function (DUF643) Microcin PF03526.13 EPA04358.1 - 0.11 12.4 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 Colicin E1 (microcin) immunity protein RHH_1 PF01402.21 EPA04359.1 - 0.029 14.3 0.4 0.04 13.9 0.4 1.3 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family VAPB_antitox PF02697.14 EPA04359.1 - 0.048 14.4 1.3 0.13 13.1 1.3 1.7 1 1 0 1 1 1 0 Putative antitoxin VapB_antitoxin PF09957.9 EPA04359.1 - 0.057 13.4 0.1 0.079 12.9 0.1 1.2 1 0 0 1 1 1 0 Bacterial antitoxin of type II TA system, VapB BrnA_antitoxin PF14384.6 EPA04359.1 - 0.065 13.7 0.2 0.11 13.1 0.2 1.3 1 1 0 1 1 1 0 BrnA antitoxin of type II toxin-antitoxin system DnaJ PF00226.31 EPA04360.1 - 1.6e-15 56.9 1.1 4e-15 55.7 1.1 1.6 1 0 0 1 1 1 1 DnaJ domain Fer4_13 PF13370.6 EPA04360.1 - 5.7e-10 39.6 1.3 1.6e-09 38.2 1.3 1.8 1 0 0 1 1 1 1 4Fe-4S single cluster domain of Ferredoxin I Fer4_15 PF13459.6 EPA04360.1 - 9e-06 26.3 3.2 6.5e-05 23.6 3.2 2.3 1 1 0 1 1 1 1 4Fe-4S single cluster domain Fer4_19 PF06902.11 EPA04360.1 - 0.0045 17.0 1.3 0.011 15.7 1.3 1.6 1 1 0 1 1 1 1 Divergent 4Fe-4S mono-cluster Fer4 PF00037.27 EPA04360.1 - 0.095 12.5 9.9 0.93 9.4 5.9 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain SRR PF07709.11 EPA04360.1 - 6.4 7.6 5.9 4.3 8.2 0.1 3.2 3 0 0 3 3 3 0 Seven Residue Repeat zf-C2H2 PF00096.26 EPA04361.1 - 0.028 14.9 3.0 0.044 14.3 3.0 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EPA04361.1 - 0.047 14.6 2.5 0.065 14.1 2.5 1.2 1 0 0 1 1 1 0 C2H2-type zinc finger LDcluster4 PF18306.1 EPA04362.1 - 5e-15 55.4 0.0 5.8e-15 55.2 0.0 1.0 1 0 0 1 1 1 1 SLOG cluster4 family LSDAT_prok PF18171.1 EPA04362.1 - 0.00014 21.1 0.1 0.00015 21.0 0.1 1.1 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Lysine_decarbox PF03641.14 EPA04362.1 - 0.011 15.8 0.3 0.027 14.6 0.3 1.7 1 1 0 1 1 1 0 Possible lysine decarboxylase DAGK_cat PF00781.24 EPA04362.1 - 0.04 13.5 0.2 0.046 13.3 0.2 1.3 1 1 0 1 1 1 0 Diacylglycerol kinase catalytic domain NAD_binding_7 PF13241.6 EPA04363.1 - 1.7e-20 73.4 0.7 5e-20 71.9 0.1 1.8 2 0 0 2 2 2 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 EPA04363.1 - 0.00042 19.7 0.0 0.0012 18.3 0.0 1.7 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central ATP-synt_F PF01990.17 EPA04363.1 - 0.0023 18.2 4.3 1 9.7 0.8 2.5 2 0 0 2 2 2 2 ATP synthase (F/14-kDa) subunit Shikimate_DH PF01488.20 EPA04363.1 - 0.0054 16.8 1.4 0.0054 16.8 1.4 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase LSDAT_prok PF18171.1 EPA04363.1 - 0.029 13.6 0.1 0.064 12.5 0.1 1.6 2 0 0 2 2 2 0 SLOG in TRPM, prokaryote GlutR_N PF05201.15 EPA04364.1 - 2.7e-37 127.8 0.1 6.6e-37 126.5 0.1 1.6 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.20 EPA04364.1 - 8e-30 103.7 0.1 1.5e-29 102.8 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GlutR_dimer PF00745.20 EPA04364.1 - 2.9e-08 34.1 1.4 8.7e-08 32.5 1.4 1.9 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain F420_oxidored PF03807.17 EPA04364.1 - 4.3e-05 24.0 0.0 0.00011 22.7 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EPA04364.1 - 0.00083 18.8 0.0 0.0041 16.5 0.0 1.9 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EPA04364.1 - 0.028 14.7 0.0 0.082 13.2 0.0 1.8 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Malic_M PF03949.15 EPA04364.1 - 0.03 13.6 0.1 0.2 10.9 0.0 2.0 1 1 1 2 2 2 0 Malic enzyme, NAD binding domain NAD_binding_7 PF13241.6 EPA04364.1 - 0.12 12.8 0.0 0.3 11.6 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF4535 PF15054.6 EPA04364.1 - 1.1 9.0 0.0 1.1 9.0 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4535) AsnC_trans_reg2 PF17805.1 EPA04366.1 - 4.1e-53 177.5 0.0 2.9e-29 101.0 0.0 3.0 3 0 0 3 3 3 2 AsnC-like ligand binding domain HTH_AsnC-type PF13404.6 EPA04366.1 - 0.00063 19.5 0.0 0.51 10.2 0.0 2.4 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.21 EPA04366.1 - 0.00067 19.6 0.1 8 6.5 0.0 4.6 3 2 1 4 4 4 1 Lrp/AsnC ligand binding domain PRA-CH PF01502.18 EPA04368.1 - 4.5e-33 112.9 0.1 5.5e-33 112.6 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase ThiF PF00899.21 EPA04369.1 - 4.3e-64 216.2 0.3 7.2e-64 215.5 0.3 1.3 1 0 0 1 1 1 1 ThiF family ThiS PF02597.20 EPA04369.1 - 1.9e-05 25.2 0.0 5.4e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 ThiS family Sacchrp_dh_NADP PF03435.18 EPA04369.1 - 0.00016 22.0 1.4 0.00064 20.0 1.4 2.0 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EPA04369.1 - 0.0067 16.5 0.1 0.02 14.9 0.1 1.8 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EPA04369.1 - 0.014 14.7 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MgsA_C PF12002.8 EPA04370.1 - 0.16 11.9 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal His_biosynth PF00977.21 EPA04371.1 - 8.9e-59 198.7 0.5 1e-58 198.5 0.5 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Dus PF01207.17 EPA04371.1 - 4.4e-08 32.6 0.4 0.00059 19.0 0.1 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) NMO PF03060.15 EPA04371.1 - 1.8e-05 24.3 0.4 0.027 13.8 0.1 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase DHO_dh PF01180.21 EPA04371.1 - 7.8e-05 22.0 0.1 0.024 13.9 0.0 2.2 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase TMP-TENI PF02581.17 EPA04371.1 - 0.00013 21.3 0.2 0.014 14.8 0.0 2.3 2 0 0 2 2 2 2 Thiamine monophosphate synthase ThiG PF05690.14 EPA04371.1 - 0.00074 18.9 0.3 0.48 9.7 0.1 2.3 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 EPA04371.1 - 0.014 14.8 0.1 1.9 7.9 0.0 2.3 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator Trp_syntA PF00290.20 EPA04371.1 - 0.061 12.2 0.0 0.088 11.6 0.0 1.3 1 0 0 1 1 1 0 Tryptophan synthase alpha chain PALP PF00291.25 EPA04372.1 - 8.9e-72 242.0 0.6 1e-71 241.8 0.6 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACP_syn_III_C PF08541.10 EPA04372.1 - 0.047 13.9 0.7 0.18 12.0 0.0 2.4 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal C1_2 PF03107.16 EPA04372.1 - 0.093 13.1 1.9 0.17 12.2 1.9 1.4 1 0 0 1 1 1 0 C1 domain zf-C2H2_11 PF16622.5 EPA04372.1 - 0.28 11.0 0.6 0.56 10.0 0.6 1.4 1 0 0 1 1 1 0 zinc-finger C2H2-type THUMP PF02926.17 EPA04373.1 - 3.9e-06 27.0 0.1 5.7e-06 26.5 0.1 1.2 1 0 0 1 1 1 1 THUMP domain Tox-PL-2 PF15643.6 EPA04373.1 - 0.074 13.2 0.2 0.17 12.0 0.2 1.6 1 0 0 1 1 1 0 Papain fold toxin 2 SRP54 PF00448.22 EPA04374.1 - 3.5e-30 105.1 0.0 5.5e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EPA04374.1 - 4.3e-26 91.4 1.0 7.9e-26 90.6 0.5 1.7 2 0 0 2 2 2 1 Signal peptide binding domain TssR PF17643.1 EPA04374.1 - 0.046 11.7 0.2 0.06 11.3 0.2 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssR Chlor_dismutase PF06778.12 EPA04375.1 - 1.3e-54 184.7 0.1 1.4e-54 184.6 0.1 1.0 1 0 0 1 1 1 1 Chlorite dismutase Aldo_ket_red PF00248.21 EPA04376.1 - 1.1e-56 192.2 0.1 1.2e-56 192.0 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1802 PF08819.11 EPA04378.1 - 1.1e-45 155.6 0.1 1.2e-45 155.5 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1802) DUF1743 PF08489.11 EPA04379.1 - 3.2e-34 117.5 0.0 1.9e-32 111.8 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1743) Asp_Glu_race PF01177.22 EPA04380.1 - 7.3e-14 52.1 0.0 1e-13 51.7 0.0 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase ATG16 PF08614.11 EPA04381.1 - 0.017 15.3 0.1 0.021 15.1 0.1 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) SMC_N PF02463.19 EPA04382.1 - 0.011 15.2 0.0 0.012 15.1 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EPA04382.1 - 0.016 15.0 0.0 0.02 14.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system FR47 PF08445.10 EPA04382.1 - 0.065 13.2 0.0 0.12 12.4 0.0 1.4 2 0 0 2 2 2 0 FR47-like protein NHL PF01436.21 EPA04383.1 - 6.3e-06 26.0 0.0 1.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 NHL repeat SGL PF08450.12 EPA04383.1 - 0.00022 20.9 0.0 0.00024 20.8 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 EPA04383.1 - 0.0024 17.8 2.1 0.0048 16.9 2.1 1.7 1 1 0 1 1 1 1 Beta-propeller repeat DHQS PF01959.16 EPA04384.1 - 8.7e-101 337.3 0.9 9.6e-101 337.2 0.9 1.0 1 0 0 1 1 1 1 3-dehydroquinate synthase II CppA_N PF14506.6 EPA04384.1 - 0.019 15.0 0.2 0.071 13.2 0.0 1.9 2 0 0 2 2 2 0 CppA N-terminal Glyco_transf_41 PF13844.6 EPA04384.1 - 0.093 11.1 0.0 0.14 10.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 41 Prot_ATP_ID_OB PF16450.5 EPA04384.1 - 0.11 12.5 0.2 0.76 9.8 0.0 2.2 2 0 0 2 2 2 0 Proteasomal ATPase OB C-terminal domain DeoC PF01791.9 EPA04385.1 - 1e-49 169.3 0.0 1.2e-49 169.0 0.0 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase DHquinase_I PF01487.15 EPA04386.1 - 2e-15 57.7 0.1 2.1e-15 57.6 0.1 1.0 1 0 0 1 1 1 1 Type I 3-dehydroquinase CBS PF00571.28 EPA04388.1 - 4.2e-21 75.1 2.3 2.4e-10 40.7 0.5 2.4 2 1 0 2 2 2 2 CBS domain IMPDH PF00478.25 EPA04388.1 - 1.4e-12 47.3 0.0 1.9e-12 46.9 0.0 1.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FAD_binding_4 PF01565.23 EPA04388.1 - 0.037 13.7 0.0 0.056 13.2 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Aldo_ket_red PF00248.21 EPA04389.1 - 1.9e-53 181.6 0.2 2.2e-53 181.4 0.2 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Spore_III_AF PF09581.10 EPA04391.1 - 0.00054 20.0 1.1 0.00089 19.3 1.1 1.3 1 0 0 1 1 1 1 Stage III sporulation protein AF (Spore_III_AF) RNA_pol_Rpc4 PF05132.14 EPA04391.1 - 0.023 15.1 0.1 0.031 14.7 0.1 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF2140 PF09911.9 EPA04391.1 - 0.42 10.1 4.1 23 4.5 0.0 2.7 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2140) Aminotran_1_2 PF00155.21 EPA04393.1 - 4.6e-41 141.2 0.0 5.9e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II S-layer PF07752.11 EPA04393.1 - 0.045 12.8 0.1 0.091 11.8 0.1 1.5 1 0 0 1 1 1 0 S-layer protein Methyltransf_21 PF05050.12 EPA04394.1 - 5.6e-11 42.8 0.6 9.3e-11 42.0 0.5 1.4 1 1 1 2 2 2 1 Methyltransferase FkbM domain EIF_2_alpha PF07541.12 EPA04395.1 - 9.7e-19 67.6 0.6 9.7e-19 67.6 0.6 1.8 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EPA04395.1 - 1.8e-12 47.4 0.2 8.7e-12 45.2 0.1 2.1 2 0 0 2 2 2 1 S1 RNA binding domain EXOSC1 PF10447.9 EPA04395.1 - 0.024 15.2 0.3 0.087 13.4 0.1 2.1 2 1 0 2 2 2 0 Exosome component EXOSC1/CSL4 PCB_OB PF17092.5 EPA04395.1 - 0.11 13.3 0.1 0.37 11.5 0.0 2.0 1 1 0 1 1 1 0 Penicillin-binding protein OB-like domain CbiA PF01656.23 EPA04396.1 - 2e-18 66.7 0.0 3e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.6 EPA04396.1 - 5.4e-13 49.2 0.5 1.5e-06 28.1 0.0 2.2 1 1 1 2 2 2 2 AAA domain CTP_synth_N PF06418.14 EPA04396.1 - 0.0094 15.3 0.6 0.024 14.0 0.1 1.8 2 0 0 2 2 2 1 CTP synthase N-terminus SRP54 PF00448.22 EPA04396.1 - 0.018 14.6 0.5 0.21 11.2 0.1 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ParA PF10609.9 EPA04396.1 - 0.07 12.6 0.5 0.28 10.6 0.0 1.9 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase AAA_18 PF13238.6 EPA04396.1 - 0.095 13.3 0.0 0.16 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF3217 PF11506.8 EPA04396.1 - 0.098 12.6 0.2 0.35 10.9 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3217) Beta_helix_2 PF18835.1 EPA04396.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Beta helix repeat of Inulin fructotransferase CBP_BcsQ PF06564.12 EPA04396.1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsQ IstB_IS21 PF01695.17 EPA04396.1 - 0.15 11.8 0.2 0.58 9.9 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein VIT_2 PF13757.6 EPA04397.1 - 0.19 11.7 0.2 0.48 10.4 0.0 1.6 2 0 0 2 2 2 0 Vault protein inter-alpha-trypsin domain CbiC PF02570.15 EPA04398.1 - 2.3e-73 246.1 1.0 2.6e-73 245.9 1.0 1.0 1 0 0 1 1 1 1 Precorrin-8X methylmutase CbiX PF01903.17 EPA04399.1 - 3.9e-16 59.3 0.0 5.1e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 CbiX CbiK PF06180.11 EPA04399.1 - 1.5e-05 24.5 0.2 1.8e-05 24.2 0.2 1.0 1 0 0 1 1 1 1 Cobalt chelatase (CbiK) Ferrochelatase PF00762.19 EPA04399.1 - 0.087 11.9 0.1 0.91 8.5 0.0 1.9 1 1 1 2 2 2 0 Ferrochelatase GATase_3 PF07685.14 EPA04400.1 - 4.4e-24 85.2 0.4 4.9e-24 85.0 0.4 1.0 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DUF1836 PF08876.11 EPA04400.1 - 0.0032 17.5 0.3 0.0053 16.8 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1836) Sec23_BS PF08033.12 EPA04400.1 - 0.062 14.0 0.0 0.086 13.6 0.0 1.3 1 0 0 1 1 1 0 Sec23/Sec24 beta-sandwich domain Beta_helix PF13229.6 EPA04400.1 - 0.062 13.1 0.4 0.081 12.8 0.4 1.4 1 1 0 1 1 1 0 Right handed beta helix region Nop10p PF04135.12 EPA04401.1 - 4.1e-23 81.2 3.5 4.2e-23 81.1 3.5 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family RecR PF02132.15 EPA04401.1 - 0.0014 18.1 1.8 0.0018 17.8 1.8 1.2 1 0 0 1 1 1 1 RecR protein PolC_DP2 PF03833.13 EPA04401.1 - 0.0074 14.2 0.2 0.0074 14.2 0.2 1.0 1 0 0 1 1 1 1 DNA polymerase II large subunit DP2 Prok-RING_4 PF14447.6 EPA04401.1 - 0.044 13.7 1.8 0.054 13.4 1.8 1.1 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 CobA_CobO_BtuR PF02572.15 EPA04402.1 - 7e-60 202.2 0.5 7.7e-60 202.1 0.5 1.0 1 0 0 1 1 1 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP AAA_14 PF13173.6 EPA04402.1 - 0.0026 17.8 0.4 0.0043 17.1 0.1 1.5 2 0 0 2 2 2 1 AAA domain YtpI PF14007.6 EPA04403.1 - 0.06 13.5 0.8 0.06 13.5 0.8 1.9 2 0 0 2 2 2 0 YtpI-like protein DUF3040 PF11239.8 EPA04403.1 - 0.098 12.9 0.3 0.37 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) DUF202 PF02656.15 EPA04403.1 - 0.14 12.6 0.8 0.62 10.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF202) DUF2371 PF10177.9 EPA04403.1 - 0.18 12.0 0.3 0.18 12.0 0.3 1.7 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) tRNA_anti-codon PF01336.25 EPA04404.1 - 6.1e-06 26.1 0.3 7.8e-06 25.8 0.3 1.2 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain REPA_OB_2 PF16900.5 EPA04404.1 - 6.4e-05 22.8 0.8 7.2e-05 22.6 0.8 1.1 1 0 0 1 1 1 1 Replication protein A OB domain HupF_HypC PF01455.18 EPA04404.1 - 0.032 14.4 0.7 4.3 7.6 0.4 2.1 1 1 1 2 2 2 0 HupF/HypC family GSDH PF07995.11 EPA04405.1 - 5.1e-20 72.1 0.0 6.2e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase HATPase_c PF02518.26 EPA04406.1 - 1.5e-22 80.2 0.2 3.3e-22 79.1 0.2 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.25 EPA04406.1 - 4.5e-13 49.2 0.0 8.9e-12 45.0 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EPA04406.1 - 1.7e-11 44.3 0.1 3.9e-11 43.1 0.1 1.7 1 0 0 1 1 1 1 PAS domain HisKA PF00512.25 EPA04406.1 - 2e-09 37.4 0.2 5e-09 36.1 0.2 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 EPA04406.1 - 5.2e-07 29.9 0.0 7.5e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 EPA04406.1 - 2.1e-06 27.9 0.0 5.6e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EPA04406.1 - 0.00018 21.5 0.0 0.00037 20.4 0.0 1.5 1 0 0 1 1 1 1 PAS domain HATPase_c_5 PF14501.6 EPA04406.1 - 0.0003 20.6 0.1 0.0011 18.8 0.0 2.0 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 EPA04406.1 - 0.018 14.9 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EPA04406.1 - 0.14 12.1 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain CRM1_repeat_2 PF18784.1 EPA04406.1 - 0.55 9.9 3.9 11 5.7 0.3 3.2 3 0 0 3 3 3 0 CRM1 / Exportin repeat 2 ASH PF15780.5 EPA04407.1 - 0.01 16.0 0.0 0.036 14.3 0.0 1.9 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin eIF-1a PF01176.19 EPA04407.1 - 0.068 13.0 0.0 60 3.6 0.0 3.4 3 0 0 3 3 3 0 Translation initiation factor 1A / IF-1 SnoaL_3 PF13474.6 EPA04408.1 - 1.6e-07 31.6 0.0 2e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain CaMKII_AD PF08332.10 EPA04408.1 - 1.1e-05 25.6 0.0 2.9e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain DUF4440 PF14534.6 EPA04408.1 - 0.00015 22.1 0.0 0.0002 21.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) ALS_ss_C PF10369.9 EPA04409.1 - 1.8e-22 79.3 0.8 5.4e-21 74.6 0.0 2.2 2 1 0 2 2 2 1 Small subunit of acetolactate synthase ACT_5 PF13710.6 EPA04409.1 - 9.2e-15 54.2 0.0 2e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 ACT domain ACT PF01842.25 EPA04409.1 - 9.9e-13 47.6 0.0 2e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 EPA04409.1 - 0.0032 18.0 0.1 0.0081 16.7 0.1 1.7 1 0 0 1 1 1 1 ACT domain ADPrib_exo_Tox PF03496.14 EPA04409.1 - 0.04 13.3 0.5 0.058 12.7 0.5 1.2 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme SLS PF14611.6 EPA04409.1 - 0.043 13.6 0.2 0.046 13.6 0.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator TPP_enzyme_N PF02776.18 EPA04410.1 - 8.1e-61 204.6 0.2 2.5e-58 196.5 0.1 2.5 2 1 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EPA04410.1 - 9.9e-48 161.4 0.1 2.1e-47 160.3 0.1 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EPA04410.1 - 1.9e-47 160.9 0.3 3.6e-46 156.7 0.1 2.8 3 1 1 4 4 4 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M_2 PF16582.5 EPA04410.1 - 0.039 13.6 0.0 0.081 12.6 0.0 1.5 1 0 0 1 1 1 0 Middle domain of thiamine pyrophosphate HMGL-like PF00682.19 EPA04411.1 - 8.8e-88 294.3 0.3 9.8e-88 294.1 0.3 1.0 1 0 0 1 1 1 1 HMGL-like Glyco_hydro_97 PF10566.9 EPA04411.1 - 0.003 16.9 0.0 0.0043 16.4 0.0 1.2 1 0 0 1 1 1 1 Glycoside hydrolase 97 AP_endonuc_2 PF01261.24 EPA04411.1 - 0.037 13.5 0.0 1 8.8 0.0 2.1 1 1 1 2 2 2 0 Xylose isomerase-like TIM barrel RIH_assoc PF08454.11 EPA04413.1 - 0.0076 16.1 1.9 0.0097 15.7 1.5 1.4 1 1 0 1 1 1 1 RyR and IP3R Homology associated DUF4473 PF14747.6 EPA04413.1 - 0.52 10.9 5.1 0.83 10.2 1.5 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4473) DUF1599 PF07659.11 EPA04416.1 - 0.13 12.7 0.4 0.21 12.0 0.4 1.3 1 0 0 1 1 1 0 Nucleotide modification associated domain 1 TFIIB PF00382.19 EPA04417.1 - 2.7e-32 110.6 6.1 3.3e-16 59.1 0.2 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EPA04417.1 - 3.6e-11 42.4 1.4 6.2e-11 41.6 1.4 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 EPA04417.1 - 5.9e-05 22.8 0.5 0.00047 19.9 0.1 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB_C_1 PF18542.1 EPA04417.1 - 0.0023 17.9 0.6 0.0062 16.5 0.6 1.7 1 0 0 1 1 1 1 Transcription factor IIB C-terminal module 1 Ribosomal_S27e PF01667.17 EPA04417.1 - 0.064 13.0 0.4 0.15 11.8 0.4 1.5 1 0 0 1 1 1 0 Ribosomal protein S27 Zn_Tnp_IS1595 PF12760.7 EPA04417.1 - 0.072 13.1 0.3 0.16 12.0 0.3 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain RB_B PF01857.20 EPA04417.1 - 0.079 13.0 0.1 0.13 12.3 0.1 1.3 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain OrfB_Zn_ribbon PF07282.11 EPA04417.1 - 0.11 12.5 0.9 0.26 11.2 0.9 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-NADH-PPase PF09297.11 EPA04417.1 - 1.6 8.5 4.2 2.5 7.9 0.2 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.6 EPA04417.1 - 3.9 7.3 6.3 17 5.3 0.3 2.5 2 0 0 2 2 2 0 zinc-ribbon domain MazE_antitoxin PF04014.18 EPA04418.1 - 0.00082 19.2 0.4 0.0013 18.6 0.1 1.5 2 0 0 2 2 2 1 Antidote-toxin recognition MazE, bacterial antitoxin GAT PF03127.14 EPA04418.1 - 0.014 15.6 0.9 0.022 15.1 0.9 1.3 1 0 0 1 1 1 0 GAT domain AbrB-like PF14250.6 EPA04418.1 - 0.026 14.6 0.0 0.062 13.4 0.0 1.6 2 0 0 2 2 2 0 AbrB-like transcriptional regulator PMSR PF01625.21 EPA04419.1 - 6.4e-67 224.5 1.0 7e-67 224.4 1.0 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Abhydrolase_1 PF00561.20 EPA04420.1 - 9.2e-29 100.9 0.0 6.8e-23 81.6 0.0 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EPA04420.1 - 6e-21 76.1 0.0 8.4e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EPA04420.1 - 2.3e-16 59.8 0.0 3.5e-16 59.2 0.0 1.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EPA04420.1 - 4.4e-06 26.6 0.1 0.15 11.9 0.0 3.2 2 1 2 4 4 4 2 Phospholipase/Carboxylesterase Ndr PF03096.14 EPA04420.1 - 1.3e-05 24.1 0.0 2e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Ndr family Ser_hydrolase PF06821.13 EPA04420.1 - 0.0002 21.3 0.0 0.043 13.7 0.0 2.8 1 1 0 1 1 1 1 Serine hydrolase DUF3530 PF12048.8 EPA04420.1 - 0.021 14.2 0.0 0.12 11.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) Abhydrolase_5 PF12695.7 EPA04420.1 - 0.047 13.4 0.0 2.6 7.8 0.0 2.6 2 1 0 2 2 2 0 Alpha/beta hydrolase family FSH1 PF03959.13 EPA04420.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.6 1 1 0 1 1 1 0 Serine hydrolase (FSH1) UPF0227 PF05728.12 EPA04420.1 - 0.14 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) MOZART2 PF12926.7 EPA04420.1 - 0.16 11.6 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated Abhydrolase_4 PF08386.10 EPA04420.1 - 0.19 11.9 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Hydrolase_4 PF12146.8 EPA04421.1 - 1.6e-13 50.5 0.0 4.4e-12 45.8 0.0 2.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EPA04421.1 - 2.6e-13 50.2 0.0 3.9e-13 49.6 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold PhaC_N PF07167.13 EPA04421.1 - 2.2e-12 47.0 0.1 4.3e-12 46.0 0.1 1.4 1 0 0 1 1 1 1 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus DUF3141 PF11339.8 EPA04421.1 - 1e-06 27.5 0.0 1.5e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3141) DLH PF01738.18 EPA04421.1 - 0.00028 20.5 0.0 0.002 17.7 0.0 2.0 2 0 0 2 2 2 1 Dienelactone hydrolase family BAAT_C PF08840.11 EPA04421.1 - 0.0066 16.4 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal PHB_depo_C PF06850.11 EPA04421.1 - 0.012 15.1 0.0 0.083 12.3 0.0 2.2 1 1 1 2 2 2 0 PHB de-polymerase C-terminus Pribosyltran PF00156.27 EPA04422.1 - 1.6e-06 27.7 0.0 0.043 13.3 0.0 2.1 1 1 1 2 2 2 2 Phosphoribosyl transferase domain FF PF01846.19 EPA04422.1 - 0.031 14.5 0.2 6.4 7.0 0.1 2.4 2 0 0 2 2 2 0 FF domain DUF956 PF06115.11 EPA04422.1 - 0.036 13.8 0.5 2.9 7.6 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF956) PHA_synth_III_E PF09712.10 EPA04423.1 - 2.2e-12 46.7 0.1 2.8e-12 46.4 0.1 1.2 1 0 0 1 1 1 1 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) DUF4200 PF13863.6 EPA04423.1 - 0.0014 19.0 5.7 0.14 12.6 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4200) Cnn_1N PF07989.11 EPA04423.1 - 0.011 15.9 3.8 0.66 10.2 3.0 2.3 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Bacillus_HBL PF05791.11 EPA04423.1 - 0.017 15.0 4.5 0.8 9.5 0.2 2.3 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) GAT PF03127.14 EPA04423.1 - 0.04 14.2 3.2 1.1 9.7 0.3 2.9 2 1 1 3 3 3 0 GAT domain Seryl_tRNA_N PF02403.22 EPA04423.1 - 0.078 13.2 6.4 0.048 13.9 2.3 2.2 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain KxDL PF10241.9 EPA04423.1 - 0.1 12.9 5.1 0.54 10.6 0.1 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein ApoLp-III PF07464.11 EPA04423.1 - 0.17 12.0 6.0 2.4 8.3 2.0 2.2 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF4094 PF13334.6 EPA04423.1 - 0.19 12.2 1.8 0.7 10.4 1.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) Retrotrans_gag PF03732.17 EPA04423.1 - 0.23 11.8 2.7 5.6 7.3 0.4 3.3 1 1 1 3 3 3 0 Retrotransposon gag protein Lge1 PF11488.8 EPA04423.1 - 0.25 11.5 8.7 0.42 10.8 2.1 2.9 2 1 1 3 3 3 0 Transcriptional regulatory protein LGE1 Uds1 PF15456.6 EPA04423.1 - 0.55 10.4 5.0 1.3 9.2 2.9 2.1 2 0 0 2 2 2 0 Up-regulated During Septation IFP_35_N PF07334.13 EPA04423.1 - 0.64 10.1 12.9 0.3 11.2 5.7 2.7 3 1 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Usp PF00582.26 EPA04424.1 - 7.1e-28 97.9 0.0 8.1e-28 97.7 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family s48_45 PF07422.13 EPA04424.1 - 0.063 13.8 0.3 0.079 13.5 0.3 1.2 1 0 0 1 1 1 0 Sexual stage antigen s48/45 domain CutA1 PF03091.15 EPA04425.1 - 1.2e-31 108.5 3.4 1.3e-31 108.3 3.4 1.0 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein GGA_N-GAT PF18308.1 EPA04425.1 - 0.29 10.8 1.9 1.2 8.9 0.0 2.5 3 0 0 3 3 3 0 GGA N-GAT domain eRF1_3 PF03465.15 EPA04426.1 - 5.1e-11 43.1 0.8 3.6e-10 40.3 0.3 2.3 2 1 0 2 2 2 1 eRF1 domain 3 eRF1_2 PF03464.15 EPA04426.1 - 1e-05 25.8 0.2 3.5e-05 24.1 0.1 1.9 1 1 0 1 1 1 1 eRF1 domain 2 Ribosomal_L7Ae PF01248.26 EPA04426.1 - 0.0049 16.6 0.0 0.0082 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family TrmB PF01978.19 EPA04428.1 - 0.09 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB RecR PF02132.15 EPA04428.1 - 0.11 12.1 0.1 0.2 11.2 0.1 1.4 1 0 0 1 1 1 0 RecR protein SUR7 PF06687.12 EPA04429.1 - 0.55 9.8 7.8 0.75 9.4 7.8 1.2 1 0 0 1 1 1 0 SUR7/PalI family AAA_lid_2 PF17863.1 EPA04430.1 - 6.9e-05 22.6 0.1 6.9e-05 22.6 0.1 1.7 2 0 0 2 2 2 1 AAA lid domain Mga PF05043.13 EPA04430.1 - 0.047 14.3 0.4 0.29 11.7 0.1 2.3 2 0 0 2 2 2 0 Mga helix-turn-helix domain PAD PF03068.15 EPA04430.1 - 0.077 12.0 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) TrmB PF01978.19 EPA04430.1 - 0.11 12.5 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB VAPB_antitox PF02697.14 EPA04432.1 - 0.009 16.8 0.3 0.011 16.5 0.3 1.2 1 0 0 1 1 1 1 Putative antitoxin Sugarporin_N PF11471.8 EPA04433.1 - 0.0055 16.6 0.1 0.0067 16.4 0.1 1.2 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension Type_III_YscX PF09474.10 EPA04434.1 - 0.12 12.7 0.1 0.14 12.4 0.1 1.1 1 0 0 1 1 1 0 Type III secretion system YscX (type_III_YscX) Terminase_6C PF17289.2 EPA04435.1 - 1.2e-08 35.2 0.7 6.2e-08 32.9 0.7 1.9 1 1 0 1 1 1 1 Terminase RNaseH-like domain Terminase_6 PF03237.15 EPA04436.1 - 0.03 14.0 0.2 0.18 11.4 0.2 2.4 1 1 0 1 1 1 0 Terminase-like family Phage_integrase PF00589.22 EPA04437.1 - 3.5e-10 39.9 0.2 3.5e-10 39.9 0.2 1.9 2 0 0 2 2 2 1 Phage integrase family F-112 PF09645.10 EPA04437.1 - 0.14 12.2 1.5 0.37 10.9 0.0 2.4 2 1 0 2 2 2 0 F-112 protein HSBP1 PF06825.12 EPA04438.1 - 0.042 13.7 0.6 7.7 6.5 0.1 2.3 2 0 0 2 2 2 0 Heat shock factor binding protein 1 KID PF02524.14 EPA04438.1 - 0.068 13.3 5.2 7 7.2 0.1 3.4 2 2 0 2 2 2 0 KID repeat DUF1922 PF09082.10 EPA04438.1 - 0.1 12.9 0.7 3.4 8.0 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1922) GTP-bdg_M PF16360.5 EPA04438.1 - 0.17 12.5 5.8 0.27 11.9 0.8 2.0 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region HNOBA PF07701.14 EPA04438.1 - 0.54 9.7 7.1 0.51 9.7 1.2 2.0 1 1 1 2 2 2 0 Heme NO binding associated GTP-bdg_M PF16360.5 EPA04439.1 - 3.4 8.3 23.8 1.6 9.4 1.4 3.9 2 1 2 4 4 4 0 GTP-binding GTPase Middle Region Transketolase_C PF02780.20 EPA04440.1 - 7.2e-31 106.6 0.0 9.7e-31 106.2 0.0 1.2 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 EPA04440.1 - 1.2e-13 51.1 0.0 1.8e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain PFOR_II PF17147.4 EPA04440.1 - 0.003 17.8 0.0 0.0056 17.0 0.0 1.4 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II TAL_FSA PF00923.19 EPA04441.1 - 2.3e-09 37.0 0.0 2.5e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase PCMT PF01135.19 EPA04442.1 - 9.4e-57 192.1 0.0 1.1e-56 191.9 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EPA04442.1 - 3.6e-09 36.6 0.0 7e-09 35.7 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 EPA04442.1 - 2.4e-08 33.8 0.0 5.8e-08 32.6 0.0 1.5 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F RrnaAD PF00398.20 EPA04442.1 - 3.4e-08 32.9 0.0 5.7e-08 32.1 0.0 1.3 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EPA04442.1 - 6.2e-07 30.0 0.0 2.2e-06 28.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA04442.1 - 3.1e-05 24.5 0.0 5.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 EPA04442.1 - 6.8e-05 22.7 0.0 0.00013 21.7 0.0 1.4 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit GidB PF02527.15 EPA04442.1 - 7e-05 22.2 0.1 0.00031 20.1 0.0 1.8 2 0 0 2 2 2 1 rRNA small subunit methyltransferase G Methyltransf_4 PF02390.17 EPA04442.1 - 0.00025 20.5 0.0 0.00048 19.7 0.0 1.5 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 EPA04442.1 - 0.00042 19.9 0.0 0.00081 19.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EPA04442.1 - 0.0022 17.3 0.0 0.0033 16.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EPA04442.1 - 0.003 16.9 0.0 0.0043 16.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Fibrillarin PF01269.17 EPA04442.1 - 0.0095 15.1 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Fibrillarin Methyltransf_32 PF13679.6 EPA04442.1 - 0.023 14.7 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.12 EPA04442.1 - 0.036 13.8 0.0 0.054 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) DOT1 PF08123.13 EPA04442.1 - 0.062 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_16 PF10294.9 EPA04442.1 - 0.084 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_24 PF13578.6 EPA04442.1 - 0.089 13.8 0.0 0.15 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 EPA04442.1 - 0.17 11.6 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein FlpD PF02662.16 EPA04443.1 - 0.0073 16.3 0.2 0.0077 16.2 0.2 1.1 1 0 0 1 1 1 1 Methyl-viologen-reducing hydrogenase, delta subunit LZ_Tnp_IS66 PF13007.7 EPA04443.1 - 0.099 13.4 0.0 0.12 13.1 0.0 1.1 1 0 0 1 1 1 0 Transposase C of IS166 homeodomain Calycin_like PF13944.6 EPA04446.1 - 0.004 17.5 1.7 0.0069 16.7 1.7 1.4 1 1 0 1 1 1 1 Calycin-like beta-barrel domain RDD PF06271.12 EPA04447.1 - 1.5e-17 64.1 2.0 2e-17 63.7 2.0 1.1 1 0 0 1 1 1 1 RDD family Methyltransf_11 PF08241.12 EPA04448.1 - 1.2e-10 41.9 0.0 2.2e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA04448.1 - 4.2e-05 24.2 0.0 6.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA04448.1 - 0.00028 20.7 0.0 0.00046 20.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EPA04448.1 - 0.003 17.5 0.0 0.0084 16.0 0.0 1.9 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_12 PF08242.12 EPA04448.1 - 0.0035 18.1 0.0 0.006 17.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CofC PF01983.16 EPA04451.1 - 6.2e-21 74.6 4.1 8e-21 74.2 4.1 1.0 1 0 0 1 1 1 1 Guanylyl transferase CofC like NTP_transf_3 PF12804.7 EPA04451.1 - 7.9e-05 23.1 0.0 8.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain RP853 PF17542.2 EPA04452.1 - 0.13 11.3 1.4 0.16 11.1 1.4 1.1 1 0 0 1 1 1 0 Uncharacterized RP853 zinc_ribbon_6 PF14599.6 EPA04453.1 - 0.00045 20.2 1.1 0.0005 20.0 1.1 1.1 1 0 0 1 1 1 1 Zinc-ribbon Cytochrome_C7 PF14522.6 EPA04453.1 - 0.0017 18.3 0.9 0.0017 18.3 0.9 1.0 1 0 0 1 1 1 1 Cytochrome c7 and related cytochrome c HypA PF01155.19 EPA04453.1 - 0.015 15.3 1.1 0.015 15.3 1.1 1.0 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1451 PF07295.11 EPA04453.1 - 0.024 14.7 2.6 0.025 14.6 2.6 1.0 1 0 0 1 1 1 0 Zinc-ribbon containing domain DYW_deaminase PF14432.6 EPA04453.1 - 0.05 13.5 1.3 0.05 13.5 1.3 1.1 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases DUF2070 PF09843.9 EPA04454.1 - 1.2e-98 330.8 0.1 1.4e-98 330.6 0.1 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) MapZ_C2 PF18708.1 EPA04454.1 - 0.081 13.2 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 MapZ extracellular C-terminal domain 2 SUI1 PF01253.22 EPA04455.1 - 2e-18 66.7 0.0 2.8e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 DTW PF03942.15 EPA04455.1 - 0.015 15.0 0.1 0.015 15.0 0.1 1.1 1 0 0 1 1 1 0 DTW domain TFIIB PF00382.19 EPA04456.1 - 9.3e-36 121.7 5.5 2.8e-18 65.7 1.3 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EPA04456.1 - 2.6e-09 36.4 1.5 4.5e-09 35.7 1.5 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Sigma70_r4 PF04545.16 EPA04456.1 - 0.00052 19.5 0.0 0.27 10.8 0.0 2.8 2 0 0 2 2 2 1 Sigma-70, region 4 Cyclin_C PF02984.19 EPA04456.1 - 0.0014 18.7 0.0 0.74 9.9 0.0 2.2 2 0 0 2 2 2 2 Cyclin, C-terminal domain Cyclin_N PF00134.23 EPA04456.1 - 0.0025 17.5 0.1 0.064 13.0 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain HTH_AsnC-type PF13404.6 EPA04456.1 - 0.0049 16.7 0.1 0.21 11.4 0.0 2.8 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain Ribosomal_S27 PF01599.19 EPA04456.1 - 0.0092 16.1 0.9 0.022 14.9 0.9 1.6 1 0 0 1 1 1 1 Ribosomal protein S27a RPW8 PF05659.11 EPA04456.1 - 0.02 14.6 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 zf-ribbon_3 PF13248.6 EPA04456.1 - 0.058 12.8 4.5 0.46 10.0 4.5 2.2 1 1 0 1 1 1 0 zinc-ribbon domain RB_B PF01857.20 EPA04456.1 - 0.059 13.4 0.0 0.13 12.3 0.0 1.5 1 1 0 1 1 1 0 Retinoblastoma-associated protein B domain DZR PF12773.7 EPA04456.1 - 0.063 13.3 0.8 0.16 12.0 0.8 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-CCHC_5 PF14787.6 EPA04456.1 - 0.072 12.8 0.5 0.072 12.8 0.5 2.2 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger HTH_Tnp_ISL3 PF13542.6 EPA04456.1 - 0.19 11.2 0.6 3.5 7.1 0.0 3.1 4 0 0 4 4 4 0 Helix-turn-helix domain of transposase family ISL3 MerR PF00376.23 EPA04456.1 - 0.35 10.7 1.3 2.6 7.9 0.0 2.7 3 0 0 3 3 3 0 MerR family regulatory protein LacI PF00356.21 EPA04456.1 - 0.35 10.7 1.5 1.7 8.5 0.2 2.7 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family zinc_ribbon_2 PF13240.6 EPA04456.1 - 0.47 10.2 5.3 3 7.7 0.5 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-NADH-PPase PF09297.11 EPA04456.1 - 1.4 8.6 9.9 0.9 9.3 0.7 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain NOB1_Zn_bind PF08772.11 EPA04456.1 - 1.7 8.9 4.0 12 6.2 0.1 2.5 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Mrr_cat PF04471.12 EPA04458.1 - 0.0037 17.3 0.0 0.006 16.6 0.0 1.3 1 0 0 1 1 1 1 Restriction endonuclease NERD PF08378.11 EPA04458.1 - 0.031 14.8 0.0 0.055 13.9 0.0 1.5 1 0 0 1 1 1 0 Nuclease-related domain UPF0102 PF02021.17 EPA04458.1 - 0.086 13.1 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0102 IMS PF00817.20 EPA04460.1 - 3.2e-41 140.8 0.1 2.3e-40 138.1 0.1 2.0 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 EPA04460.1 - 1.4e-10 41.9 0.3 2.9e-10 40.9 0.3 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EPA04460.1 - 7e-07 29.2 0.0 1.8e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif Cdd1 PF11731.8 EPA04460.1 - 0.0089 16.2 0.1 0.049 13.9 0.0 2.3 3 0 0 3 3 3 1 Pathogenicity locus UPF0242 PF06785.11 EPA04460.1 - 0.014 15.5 3.4 0.024 14.8 3.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus 7TMR-HDED PF07697.11 EPA04460.1 - 0.045 13.9 1.6 0.19 11.8 1.6 2.0 1 1 0 1 1 1 0 7TM-HD extracellular DUF2524 PF10732.9 EPA04460.1 - 0.054 13.8 3.1 0.062 13.6 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) NPV_P10 PF05531.12 EPA04460.1 - 1.9 9.0 5.0 25 5.4 1.6 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF3797 PF12677.7 EPA04461.1 - 0.055 13.4 0.1 0.088 12.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) zinc-ribbon_6 PF10005.9 EPA04461.1 - 0.099 13.3 0.1 0.15 12.8 0.1 1.6 1 1 0 1 1 1 0 zinc-ribbon domain zf_UBZ PF18439.1 EPA04461.1 - 0.17 11.5 0.4 0.34 10.5 0.1 1.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF2070 PF09843.9 EPA04463.1 - 2.5e-13 49.2 11.2 2.9e-13 49.0 11.2 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) DUF1230 PF06799.11 EPA04463.1 - 0.4 10.8 2.9 0.24 11.5 1.0 1.6 1 1 1 2 2 2 0 Conserved in the green lineage and diatoms 27 IncD PF17628.2 EPA04463.1 - 0.65 9.8 3.9 0.59 9.9 2.1 1.9 1 1 0 1 1 1 0 Inclusion membrane protein D adh_short_C2 PF13561.6 EPA04464.1 - 1.9e-68 230.5 0.4 2.2e-68 230.3 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EPA04464.1 - 7.5e-61 205.0 1.1 8.8e-61 204.8 1.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EPA04464.1 - 3.3e-09 36.9 0.3 4.6e-09 36.4 0.3 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EPA04464.1 - 2.7e-05 23.8 1.2 6.1e-05 22.6 1.2 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 EPA04464.1 - 0.00023 21.7 1.3 0.00036 21.0 0.6 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 EPA04464.1 - 0.0019 18.1 0.3 0.0033 17.4 0.3 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DFP PF04127.15 EPA04464.1 - 0.0031 17.4 0.2 0.0059 16.5 0.2 1.4 1 1 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein GDP_Man_Dehyd PF16363.5 EPA04464.1 - 0.0059 16.0 1.7 0.024 14.1 1.7 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EPA04464.1 - 0.009 15.2 2.3 0.012 14.8 2.3 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EPA04464.1 - 0.058 13.5 1.0 0.15 12.2 1.0 1.8 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 5_nucleotid_C PF02872.18 EPA04464.1 - 0.096 12.9 0.1 0.16 12.2 0.1 1.3 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain DUF2660 PF10859.8 EPA04464.1 - 0.15 12.6 0.0 0.43 11.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2660) DUF99 PF01949.16 EPA04466.1 - 1.7e-54 184.0 0.0 1.9e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF99 Kinase-PolyVal PF18762.1 EPA04466.1 - 0.078 12.9 0.2 0.12 12.3 0.2 1.3 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins NAD_binding_2 PF03446.15 EPA04467.1 - 8.3e-37 126.8 0.6 1.5e-36 126.0 0.6 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EPA04467.1 - 1.6e-19 70.3 0.0 2.8e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 EPA04467.1 - 6.2e-07 29.6 0.2 1.1e-06 28.7 0.2 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EPA04467.1 - 1.4e-06 28.8 1.2 2.8e-06 27.8 0.6 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EPA04467.1 - 3.5e-05 23.2 0.1 6.6e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EPA04467.1 - 3.5e-05 23.5 0.1 6.1e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 EPA04467.1 - 5.5e-05 23.1 0.5 0.0014 18.6 0.5 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Rossmann-like PF10727.9 EPA04467.1 - 8.9e-05 22.3 0.1 0.0041 17.0 0.1 2.3 1 1 1 2 2 2 1 Rossmann-like domain IlvN PF07991.12 EPA04467.1 - 0.0003 20.4 0.2 0.00071 19.2 0.2 1.7 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_N PF03721.14 EPA04467.1 - 0.00031 20.4 1.7 0.067 12.8 0.1 2.3 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EPA04467.1 - 0.001 19.1 0.1 0.0046 16.9 0.1 2.1 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.19 EPA04467.1 - 0.062 12.5 0.1 0.092 12.0 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 EPA04469.1 - 1.9e-17 63.9 0.6 1e-07 31.9 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EPA04469.1 - 3.5e-16 59.4 0.0 5.3e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EPA04469.1 - 6.5e-14 52.1 0.1 9.1e-14 51.6 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EPA04469.1 - 1.9e-12 46.8 0.2 2.8e-07 29.8 0.0 2.2 1 1 1 2 2 2 2 Tryptophan halogenase FAD_binding_2 PF00890.24 EPA04469.1 - 3.6e-11 42.8 0.5 4.4e-07 29.3 0.1 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EPA04469.1 - 1.8e-09 37.3 1.9 1.1e-06 28.2 0.3 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EPA04469.1 - 3.4e-08 32.6 0.4 3.6e-06 26.0 0.1 2.1 2 0 0 2 2 2 2 HI0933-like protein Lycopene_cycl PF05834.12 EPA04469.1 - 7.4e-08 31.8 0.1 1.1e-07 31.3 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 EPA04469.1 - 8.5e-07 28.4 0.8 5.5e-05 22.5 0.1 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EPA04469.1 - 1.6e-06 28.2 0.1 6.4e-06 26.3 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EPA04469.1 - 3e-06 26.6 0.6 1e-05 24.8 0.3 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.27 EPA04469.1 - 8e-05 23.1 1.1 0.058 14.0 0.2 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EPA04469.1 - 0.00012 21.5 1.1 0.00031 20.1 1.1 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EPA04469.1 - 0.024 14.5 0.2 0.063 13.2 0.1 1.6 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 EPA04469.1 - 0.13 12.6 0.1 0.29 11.4 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain GMC_oxred_N PF00732.19 EPA04469.1 - 0.15 11.4 0.2 1.2 8.4 0.0 2.0 2 0 0 2 2 2 0 GMC oxidoreductase Auto_anti-p27 PF06677.12 EPA04470.1 - 1.3e-09 38.1 2.4 1.9e-09 37.5 2.4 1.3 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) TIP120 PF08623.10 EPA04470.1 - 0.01 15.6 3.4 0.012 15.4 3.4 1.1 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) DUF1178 PF06676.11 EPA04470.1 - 0.024 15.0 0.5 0.032 14.6 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) DUF3422 PF11902.8 EPA04470.1 - 0.2 10.7 1.7 0.23 10.5 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3422) FUSC-like PF12805.7 EPA04470.1 - 0.23 10.5 1.5 0.27 10.3 1.5 1.1 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS TF_Zn_Ribbon PF08271.12 EPA04470.1 - 0.83 9.2 3.6 1.1 8.9 1.5 2.2 2 1 0 2 2 2 0 TFIIB zinc-binding Holin_BhlA PF10960.8 EPA04470.1 - 1.5 8.8 5.9 3.1 7.9 5.9 1.6 1 1 0 1 1 1 0 BhlA holin family UPF0052 PF01933.18 EPA04471.1 - 3.1e-58 197.3 0.1 3.7e-58 197.1 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 zf-H2C2_5 PF13909.6 EPA04472.1 - 3.1e-05 23.6 0.7 4.6e-05 23.1 0.7 1.3 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 EPA04472.1 - 0.0005 20.4 1.3 0.00082 19.7 1.3 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EPA04472.1 - 0.0016 19.1 1.4 0.003 18.3 1.4 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger OrsD PF12013.8 EPA04472.1 - 0.06 13.8 0.0 0.07 13.6 0.0 1.2 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D LIM_bind PF01803.16 EPA04472.1 - 0.093 12.3 0.5 0.13 11.7 0.5 1.2 1 0 0 1 1 1 0 LIM-domain binding protein ADD_DNMT3 PF17980.1 EPA04473.1 - 0.0043 17.0 2.3 0.0057 16.6 2.3 1.4 1 0 0 1 1 1 1 Cysteine rich ADD domain in DNMT3 PolC_DP2 PF03833.13 EPA04473.1 - 0.17 9.7 3.3 0.15 9.9 3.3 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Methyltransf_11 PF08241.12 EPA04474.1 - 7.5e-19 68.2 0.0 1.4e-18 67.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EPA04474.1 - 1e-17 64.4 0.0 1.3e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA04474.1 - 9.1e-17 61.6 0.0 3.1e-16 59.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA04474.1 - 2.8e-16 60.0 0.0 6.2e-16 58.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA04474.1 - 7.8e-15 55.0 0.1 1.1e-14 54.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EPA04474.1 - 2.5e-10 39.8 0.1 6e-10 38.5 0.0 1.6 1 1 0 2 2 2 1 Protein of unknown function (DUF1698) NodS PF05401.11 EPA04474.1 - 4.8e-10 39.4 0.0 5.8e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 EPA04474.1 - 1.8e-09 37.3 1.2 2.5e-09 36.8 1.2 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EPA04474.1 - 5.9e-09 35.6 0.2 9.7e-06 25.2 0.0 2.2 2 0 0 2 2 2 2 Putative methyltransferase MetW PF07021.12 EPA04474.1 - 2.1e-06 27.4 0.1 1.4e-05 24.8 0.0 1.9 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW DOT1 PF08123.13 EPA04474.1 - 1.6e-05 24.5 0.1 0.00027 20.5 0.0 2.1 1 1 0 2 2 2 1 Histone methylation protein DOT1 CMAS PF02353.20 EPA04474.1 - 7.2e-05 22.2 0.7 9.5e-05 21.8 0.7 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase AdoMet_MTase PF07757.13 EPA04474.1 - 9.6e-05 22.7 1.4 0.00019 21.7 0.0 2.0 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 EPA04474.1 - 0.00073 19.6 0.1 0.0032 17.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain DREV PF05219.12 EPA04474.1 - 0.00096 18.3 0.2 0.0014 17.8 0.2 1.3 1 1 0 1 1 1 1 DREV methyltransferase Methyltransf_18 PF12847.7 EPA04474.1 - 0.0014 18.6 0.0 0.0025 17.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 EPA04474.1 - 0.0022 17.3 0.0 0.0055 16.1 0.0 1.7 1 1 0 1 1 1 1 rRNA small subunit methyltransferase G MTS PF05175.14 EPA04474.1 - 0.0032 17.0 0.0 0.0051 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain ActA PF05058.12 EPA04474.1 - 0.013 13.8 0.3 0.021 13.2 0.3 1.3 1 0 0 1 1 1 0 ActA Protein PCMT PF01135.19 EPA04474.1 - 0.032 14.0 0.0 0.067 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Sec61_beta PF03911.16 EPA04475.1 - 5.4e-13 48.7 0.4 6.4e-13 48.5 0.4 1.1 1 0 0 1 1 1 1 Sec61beta family CPBP PF02517.16 EPA04476.1 - 9.4e-13 48.4 7.3 9.4e-13 48.4 7.3 2.5 1 1 1 2 2 2 1 CPBP intramembrane metalloprotease CoxIIa PF08113.11 EPA04476.1 - 3.5 7.5 8.8 14 5.6 1.0 3.2 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IIa family SRTM1 PF15872.5 EPA04477.1 - 0.24 11.6 3.1 0.29 11.3 0.0 2.5 3 0 0 3 3 3 0 Serine-rich and transmembrane domain-containing protein 1 Peripla_BP_2 PF01497.18 EPA04479.1 - 3.7e-23 82.3 0.0 5.4e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Nre_N PF04894.12 EPA04480.1 - 3.3e-91 305.9 0.0 4.7e-91 305.4 0.0 1.1 1 0 0 1 1 1 1 Archaeal Nre, N-terminal Nre_C PF04895.12 EPA04480.1 - 4.3e-32 110.3 0.0 6.8e-32 109.7 0.0 1.3 1 0 0 1 1 1 1 Archaeal Nre, C-terminal ADH_zinc_N PF00107.26 EPA04481.1 - 4e-25 88.3 0.0 6.4e-25 87.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EPA04481.1 - 2.3e-17 64.3 0.0 3.6e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ACP_syn_III_C PF08541.10 EPA04481.1 - 0.019 15.1 0.2 0.062 13.5 0.0 1.9 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal TPR_1 PF00515.28 EPA04482.1 - 5.1e-08 32.4 3.7 0.00014 21.6 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EPA04482.1 - 9.4e-05 22.2 1.6 0.0012 18.8 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EPA04482.1 - 0.0007 19.6 1.3 1.1 9.6 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF4919 PF16266.5 EPA04482.1 - 0.017 15.0 0.1 0.017 15.0 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4919) TPR_11 PF13414.6 EPA04482.1 - 0.021 14.5 0.7 0.038 13.7 0.6 1.6 1 1 0 1 1 1 0 TPR repeat TPR_10 PF13374.6 EPA04482.1 - 0.022 14.6 0.2 6.7 6.7 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 EPA04482.1 - 0.027 14.9 1.1 0.074 13.5 0.5 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EPA04482.1 - 0.03 14.8 0.0 0.039 14.5 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 EPA04482.1 - 0.033 14.8 0.1 0.086 13.5 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 EPA04482.1 - 0.04 13.9 0.7 0.062 13.3 0.1 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EPA04482.1 - 0.054 14.2 0.0 0.062 14.0 0.0 1.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 EPA04482.1 - 0.11 12.9 0.3 1.4 9.2 0.3 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 EPA04482.1 - 0.11 13.3 0.0 0.15 12.9 0.0 1.3 1 1 0 1 1 1 0 Tetratricopeptide repeat Chlor_dismutase PF06778.12 EPA04483.1 - 1.6e-54 184.4 0.1 1.8e-54 184.3 0.1 1.0 1 0 0 1 1 1 1 Chlorite dismutase DUF1802 PF08819.11 EPA04484.1 - 5.7e-48 163.0 0.4 6.4e-48 162.9 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1802) Copper-bind PF00127.20 EPA04485.1 - 2.7e-17 63.0 1.9 5.2e-09 36.5 0.2 2.5 2 0 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 EPA04485.1 - 1.2e-13 51.1 0.0 9.6e-06 25.7 0.0 2.6 2 0 0 2 2 2 2 Cupredoxin-like domain TonB_N PF16031.5 EPA04485.1 - 1.2 9.6 29.3 0.14 12.7 15.9 2.3 2 0 0 2 2 2 0 TonB polyproline region Trypan_PARP PF05887.11 EPA04485.1 - 7.1 6.6 26.5 0.62 10.1 16.3 2.9 2 1 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Hint_2 PF13403.6 EPA04486.1 - 2.7e-06 27.7 0.2 1.2e-05 25.7 0.1 2.0 1 1 0 1 1 1 1 Hint domain Vint PF14623.6 EPA04486.1 - 0.08 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Hint-domain TF_Zn_Ribbon PF08271.12 EPA04486.1 - 0.084 12.4 0.4 0.16 11.5 0.4 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding PDDEXK_7 PF04411.12 EPA04487.1 - 0.004 17.1 0.2 0.095 12.7 0.2 2.5 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Microvir_H PF04687.12 EPA04487.1 - 0.019 14.3 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) DUF4513 PF14983.6 EPA04488.1 - 0.054 13.6 0.0 0.069 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4513) AAA_5 PF07728.14 EPA04489.1 - 4.2e-13 49.5 0.0 9.9e-13 48.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Copper-bind PF00127.20 EPA04489.1 - 3e-06 27.6 1.0 0.00012 22.4 0.2 2.9 2 0 0 2 2 2 1 Copper binding proteins, plastocyanin/azurin family AAA_18 PF13238.6 EPA04489.1 - 0.0013 19.3 0.1 0.067 13.7 0.0 3.3 3 0 0 3 3 2 1 AAA domain AAA_3 PF07726.11 EPA04489.1 - 0.0039 17.0 0.0 3.5 7.5 0.0 3.5 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EPA04489.1 - 0.0044 16.4 0.0 0.015 14.7 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EPA04489.1 - 0.0066 16.2 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EPA04489.1 - 0.01 16.3 0.1 0.053 13.9 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 EPA04489.1 - 0.013 15.8 0.0 0.4 11.0 0.0 2.6 1 1 0 1 1 1 0 AAA domain Cupredoxin_1 PF13473.6 EPA04489.1 - 0.019 15.1 0.0 0.047 13.8 0.0 1.7 1 0 0 1 1 1 0 Cupredoxin-like domain RuvB_N PF05496.12 EPA04489.1 - 0.026 14.3 0.0 0.074 12.8 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 EPA04489.1 - 0.051 13.6 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 EPA04489.1 - 0.068 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_7 PF12775.7 EPA04489.1 - 0.09 12.3 0.3 0.42 10.1 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region HOIP-UBA PF16678.5 EPA04489.1 - 0.091 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 HOIP UBA domain pair zf-LYAR PF08790.11 EPA04490.1 - 0.0023 17.8 0.6 0.8 9.7 0.1 2.3 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger zf-C2H2_4 PF13894.6 EPA04490.1 - 0.0068 17.1 4.9 1.4 10.0 0.8 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EPA04490.1 - 0.011 16.1 5.9 0.059 13.8 0.1 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EPA04490.1 - 0.36 11.2 6.9 5.1 7.5 0.4 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_8 PF15909.5 EPA04490.1 - 0.57 10.5 3.1 0.87 9.9 3.1 1.2 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 EPA04490.1 - 2.5 8.7 8.8 3.5 8.2 0.0 2.8 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 EPA04490.1 - 7.1 6.8 7.8 1.7 8.7 2.6 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger DUF2107 PF09880.9 EPA04492.1 - 0.0046 17.0 3.4 0.0055 16.8 3.4 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2107) CRPA PF05745.11 EPA04492.1 - 0.014 15.4 5.7 0.016 15.2 5.7 1.0 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) TrbC PF04956.13 EPA04492.1 - 0.034 14.4 1.5 0.04 14.1 1.5 1.1 1 0 0 1 1 1 0 TrbC/VIRB2 family Saf_2TM PF18303.1 EPA04492.1 - 0.28 10.8 1.7 0.56 9.8 0.1 1.9 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain Fst_toxin PF13955.6 EPA04492.1 - 1.3 9.0 10.9 0.4 10.7 4.0 2.2 2 0 0 2 2 2 0 Toxin Fst, type I toxin-antitoxin system Phage_Gp15 PF06854.11 EPA04493.1 - 0.025 14.6 0.3 0.026 14.5 0.3 1.0 1 0 0 1 1 1 0 Bacteriophage Gp15 protein Peripla_BP_4 PF13407.6 EPA04494.1 - 1.3e-11 44.6 0.0 1.6e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein domain NYN PF01936.18 EPA04494.1 - 0.0055 17.2 0.0 0.016 15.7 0.0 1.7 2 0 0 2 2 2 1 NYN domain PGM_PMM_II PF02879.16 EPA04494.1 - 0.075 13.7 0.0 3.9 8.2 0.0 2.6 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II DUF72 PF01904.18 EPA04495.1 - 2.5e-46 158.5 0.0 3.1e-46 158.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF72 LapA_dom PF06305.11 EPA04496.1 - 0.0008 19.2 0.3 0.0008 19.2 0.3 2.2 2 1 0 2 2 2 1 Lipopolysaccharide assembly protein A domain SieB PF14163.6 EPA04496.1 - 0.0013 18.3 0.9 0.0015 18.0 0.9 1.1 1 0 0 1 1 1 1 Super-infection exclusion protein B DUF2207 PF09972.9 EPA04496.1 - 0.0013 17.6 0.1 0.0014 17.5 0.1 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DivIC PF04977.15 EPA04496.1 - 0.0016 18.2 0.2 0.0016 18.2 0.2 1.6 2 0 0 2 2 1 1 Septum formation initiator Vpu PF00558.19 EPA04496.1 - 0.0018 18.0 0.8 0.0018 18.0 0.8 2.0 2 0 0 2 2 2 1 Vpu protein DUF4199 PF13858.6 EPA04496.1 - 0.0052 17.2 0.7 0.0066 16.9 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) OPA3 PF07047.12 EPA04496.1 - 0.016 15.0 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) Chordopox_A13L PF05961.11 EPA04496.1 - 0.018 15.3 0.4 0.036 14.3 0.4 1.5 1 0 0 1 1 1 0 Chordopoxvirus A13L protein 7TM_GPCR_Sra PF02117.16 EPA04496.1 - 0.025 13.4 1.6 0.027 13.3 1.6 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sra Connexin PF00029.19 EPA04496.1 - 0.028 14.2 0.2 0.037 13.8 0.1 1.3 1 1 0 1 1 1 0 Connexin Ly49 PF08391.10 EPA04496.1 - 0.028 14.8 0.1 0.028 14.8 0.1 1.5 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region EphA2_TM PF14575.6 EPA04496.1 - 0.034 15.0 1.1 0.075 13.9 0.0 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain THEG4 PF15834.5 EPA04496.1 - 0.038 14.0 0.0 0.047 13.7 0.0 1.1 1 0 0 1 1 1 0 Testis highly expressed protein 4 Virul_fac_BrkB PF03631.15 EPA04496.1 - 0.045 13.4 2.4 0.051 13.2 2.4 1.0 1 0 0 1 1 1 0 Virulence factor BrkB DUF2298 PF10060.9 EPA04496.1 - 0.053 12.2 0.0 0.059 12.1 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) ECSCR PF15820.5 EPA04496.1 - 0.06 13.2 0.1 0.06 13.2 0.1 1.6 1 1 1 2 2 2 0 Endothelial cell-specific chemotaxis regulator CcmH PF03918.14 EPA04496.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Cytochrome C biogenesis protein Glycophorin_A PF01102.18 EPA04496.1 - 0.12 12.6 0.2 0.12 12.6 0.2 1.5 2 0 0 2 2 1 0 Glycophorin A DUF4381 PF14316.6 EPA04496.1 - 0.13 12.5 0.1 0.2 11.9 0.0 1.4 2 0 0 2 2 1 0 Domain of unknown function (DUF4381) COX14 PF14880.6 EPA04496.1 - 0.16 11.8 0.3 0.3 11.0 0.0 1.7 2 0 0 2 2 1 0 Cytochrome oxidase c assembly 7tm_1 PF00001.21 EPA04496.1 - 0.17 11.1 6.3 1.1 8.5 0.1 2.0 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) EIIC-GAT PF03611.14 EPA04496.1 - 0.2 10.7 7.3 4.7 6.2 9.1 1.8 1 1 1 2 2 2 0 PTS system sugar-specific permease component DUF3169 PF11368.8 EPA04496.1 - 0.67 9.4 7.5 0.11 12.1 0.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) DUF4083 PF13314.6 EPA04496.1 - 0.77 9.7 10.9 0.061 13.3 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) TipE PF16972.5 EPA04496.1 - 1.1 8.4 3.8 0.22 10.7 0.9 1.4 1 1 1 2 2 2 0 Na+ channel auxiliary subunit TipE TNFR_16_TM PF18422.1 EPA04496.1 - 1.2 9.1 8.2 0.25 11.3 1.1 2.5 2 1 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain Phage_Gp23 PF10669.9 EPA04496.1 - 1.8 8.9 10.2 0.036 14.4 2.4 1.9 1 1 1 2 2 2 0 Protein gp23 (Bacteriophage A118) TMEM154 PF15102.6 EPA04496.1 - 4.2 7.3 7.9 0.1 12.5 0.4 1.9 1 1 1 2 2 2 0 TMEM154 protein family Sigma_reg_N PF13800.6 EPA04496.1 - 4.6 7.6 10.0 2 8.8 0.2 2.2 1 1 1 2 2 2 0 Sigma factor regulator N-terminal RIC3 PF15361.6 EPA04496.1 - 5 7.5 11.2 0.33 11.3 6.0 1.8 2 1 0 2 2 1 0 Resistance to inhibitors of cholinesterase homologue 3 YajC PF02699.15 EPA04496.1 - 5.8 6.9 9.3 0.14 12.1 0.9 2.4 2 1 0 2 2 2 0 Preprotein translocase subunit TcpE PF12648.7 EPA04496.1 - 6.4 7.4 9.5 9.2 6.9 9.5 1.3 1 1 0 1 1 1 0 TcpE family DUF2839 PF10999.8 EPA04498.1 - 0.15 12.4 0.3 0.15 12.4 0.3 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2839) DUF2207 PF09972.9 EPA04498.1 - 0.55 8.9 3.1 0.57 8.9 3.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Response_reg PF00072.24 EPA04499.1 - 2e-25 89.1 3.1 2.2e-25 89.0 3.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain FleQ PF06490.11 EPA04499.1 - 0.015 15.7 0.2 0.035 14.5 0.2 1.8 1 1 0 1 1 1 0 Flagellar regulatory protein FleQ TrkA_N PF02254.18 EPA04499.1 - 0.028 14.7 1.7 0.051 13.8 1.7 1.5 1 1 0 1 1 1 0 TrkA-N domain Radical_SAM PF04055.21 EPA04501.1 - 1.5e-20 74.2 0.0 5.2e-20 72.5 0.0 1.8 1 1 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.12 EPA04501.1 - 2.4e-20 72.6 0.1 1.8e-19 69.9 0.1 2.3 2 0 0 2 2 2 1 Wyosine base formation Fer4_14 PF13394.6 EPA04501.1 - 0.036 14.2 1.5 0.75 9.9 0.8 2.9 2 1 0 2 2 2 0 4Fe-4S single cluster domain SAS4 PF15460.6 EPA04501.1 - 0.044 13.9 0.6 0.099 12.7 0.3 1.8 1 1 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 AAT PF03417.16 EPA04501.1 - 0.09 12.5 0.1 0.17 11.5 0.0 1.5 1 1 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Peptidase_M22 PF00814.25 EPA04502.1 - 1.4e-75 254.5 0.0 1.7e-75 254.2 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Lactamase_B_2 PF12706.7 EPA04504.1 - 2.3e-11 43.6 0.0 3.2e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EPA04504.1 - 5.9e-11 42.7 1.2 1e-09 38.7 1.3 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 EPA04504.1 - 1.9e-08 34.0 0.0 2.7e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EPA04504.1 - 3.6e-06 27.0 0.0 1.4e-05 25.1 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain TSP_3 PF02412.18 EPA04505.1 - 7.1e-07 28.8 10.1 0.00016 21.3 2.6 3.5 3 1 0 3 3 3 2 Thrombospondin type 3 repeat DUF282 PF03380.14 EPA04505.1 - 0.0021 17.9 0.4 2.8 7.9 0.1 2.6 2 0 0 2 2 2 2 Caenorhabditis protein of unknown function, DUF282 FOXP-CC PF16159.5 EPA04505.1 - 0.074 13.7 0.0 0.093 13.4 0.0 1.1 1 0 0 1 1 1 0 FOXP coiled-coil domain U71 PF17474.2 EPA04505.1 - 0.083 12.8 0.0 1.3 9.0 0.0 2.1 2 0 0 2 2 2 0 Tegument protein UL11 homolog Excalibur PF05901.11 EPA04505.1 - 0.12 13.0 9.1 0.71 10.5 0.7 3.1 3 1 0 3 3 3 0 Excalibur calcium-binding domain VCBS PF13517.6 EPA04505.1 - 0.91 10.2 5.3 7 7.3 0.1 3.1 2 1 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Rax2 PF12768.7 EPA04507.1 - 0.011 15.2 0.1 0.011 15.2 0.1 1.1 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF2834 PF11196.8 EPA04507.1 - 0.11 12.9 0.0 0.11 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2834) Mid2 PF04478.12 EPA04507.1 - 0.15 11.9 0.2 0.15 11.9 0.2 1.1 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor MMR_HSR1_C PF08438.10 EPA04508.1 - 1.8e-29 102.6 0.8 5.6e-29 101.0 0.2 2.0 2 0 0 2 2 2 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EPA04508.1 - 2.9e-20 72.5 0.0 8.7e-19 67.7 0.0 2.8 2 1 0 3 3 3 1 50S ribosome-binding GTPase TGS PF02824.21 EPA04508.1 - 1.4e-12 47.5 0.2 3.4e-12 46.2 0.2 1.7 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EPA04508.1 - 4e-06 26.4 0.1 1.6e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B YchF-GTPase_C PF06071.13 EPA04508.1 - 0.0023 18.1 0.3 0.012 15.8 0.2 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1_Xtn PF16897.5 EPA04508.1 - 0.087 12.9 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Cation_efflux PF01545.21 EPA04509.1 - 3.6e-33 115.0 11.8 4.3e-33 114.7 11.8 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EPA04509.1 - 0.00024 21.2 2.6 0.00038 20.5 2.6 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Spore_YhcN_YlaJ PF09580.10 EPA04509.1 - 0.11 12.6 0.3 0.17 11.9 0.3 1.2 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) ThrE PF06738.12 EPA04509.1 - 0.96 8.8 7.2 2 7.7 0.5 2.9 2 1 0 3 3 3 0 Putative threonine/serine exporter Cytochrome_B PF00033.19 EPA04510.1 - 1.3e-29 103.4 9.9 1.3e-29 103.4 9.9 2.4 3 0 0 3 3 3 1 Cytochrome b/b6/petB Cytochrom_B_N_2 PF13631.6 EPA04510.1 - 2e-25 89.8 6.3 2e-25 89.8 6.3 3.1 3 1 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.17 EPA04510.1 - 1.5e-09 38.1 1.3 1.5e-09 38.1 1.3 3.1 3 0 0 3 3 3 1 Cytochrome b(C-terminal)/b6/petD DUF4405 PF14358.6 EPA04510.1 - 7.3e-05 23.2 3.5 7.3e-05 23.2 3.5 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4405) UPF0542 PF15086.6 EPA04510.1 - 0.0053 16.6 0.2 0.0053 16.6 0.2 2.2 2 0 0 2 2 2 1 Uncharacterised protein family UPF0542 DUF3899 PF13038.6 EPA04510.1 - 0.26 11.8 0.0 0.26 11.8 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3899) PTPLA PF04387.14 EPA04510.1 - 7.6 6.3 11.4 1.8 8.2 0.4 3.2 2 2 1 3 3 3 0 Protein tyrosine phosphatase-like protein, PTPLA TSP_3 PF02412.18 EPA04511.1 - 3.2e-56 186.7 232.0 1.4e-05 24.6 1.5 25.8 21 10 4 25 25 25 20 Thrombospondin type 3 repeat DUF282 PF03380.14 EPA04511.1 - 3.9e-08 33.1 33.6 7 6.7 0.1 14.1 15 0 0 15 15 15 5 Caenorhabditis protein of unknown function, DUF282 AKAP7_RIRII_bdg PF10470.9 EPA04511.1 - 0.00085 19.3 0.2 12 6.1 0.0 6.4 8 0 0 8 8 8 1 PKA-RI-RII subunit binding domain of A-kinase anchor protein NOPS PF08075.11 EPA04511.1 - 9.1 6.6 19.7 1.7e+02 2.5 0.1 9.9 12 0 0 12 12 12 0 NOPS (NUC059) domain HhH-GPD PF00730.25 EPA04512.1 - 2.5e-08 34.3 0.0 3.3e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EPA04512.1 - 0.084 12.8 0.0 0.6 10.1 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif OGG_N PF07934.12 EPA04513.1 - 7e-12 45.5 0.2 4.7e-09 36.4 0.2 2.1 1 1 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain RNA_helicase PF00910.22 EPA04513.1 - 0.0061 16.9 0.2 0.0096 16.3 0.2 1.4 1 0 0 1 1 1 1 RNA helicase GP57 PF17594.2 EPA04514.1 - 0.042 13.6 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 Phage Tail fiber assembly helper gene product 57 7kD_DNA_binding PF02294.18 EPA04514.1 - 0.065 13.3 0.3 0.1 12.7 0.3 1.4 1 0 0 1 1 1 0 7kD DNA-binding domain PH_2 PF08458.10 EPA04514.1 - 0.083 13.3 0.2 0.13 12.6 0.2 1.3 1 1 0 1 1 1 0 Plant pleckstrin homology-like region TSP_3 PF02412.18 EPA04515.1 - 1.3e-14 53.6 47.6 0.00082 19.0 3.0 6.7 4 3 1 5 5 5 4 Thrombospondin type 3 repeat Fer4_13 PF13370.6 EPA04515.1 - 0.086 13.4 5.2 8.4 7.0 0.0 4.0 2 2 1 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I NOPS PF08075.11 EPA04515.1 - 0.25 11.6 1.4 64 3.8 0.0 3.7 3 0 0 3 3 3 0 NOPS (NUC059) domain DUF282 PF03380.14 EPA04515.1 - 0.25 11.3 3.7 11 6.1 0.1 3.7 4 0 0 4 4 4 0 Caenorhabditis protein of unknown function, DUF282 DUF2709 PF10915.8 EPA04515.1 - 0.3 10.3 0.8 0.64 9.2 0.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2709) EF-hand_5 PF13202.6 EPA04515.1 - 1.5 8.4 8.9 19 5.0 0.2 3.9 3 0 0 3 3 3 0 EF hand RMMBL PF07521.12 EPA04516.1 - 2.6e-17 62.5 0.1 3.5e-17 62.1 0.1 1.2 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Beta-Casp PF10996.8 EPA04516.1 - 2.1e-06 28.0 0.0 3.5e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Beta-Casp domain NB-ARC PF00931.22 EPA04516.1 - 0.026 13.7 0.0 0.032 13.4 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain TGT PF01702.18 EPA04517.1 - 1.8e-68 231.3 0.0 2.3e-68 230.9 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase DUF5591 PF17884.1 EPA04517.1 - 1.4e-10 41.2 0.2 2.7e-10 40.3 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5591) Fer4 PF00037.27 EPA04518.1 - 2e-11 43.2 10.3 7.8e-06 25.5 0.4 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EPA04518.1 - 4.5e-09 36.7 3.2 6.5e-09 36.2 3.2 1.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EPA04518.1 - 8.1e-09 35.2 7.3 7.8e-05 22.6 1.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 EPA04518.1 - 1.2e-08 34.9 1.5 1.7e-08 34.4 1.5 1.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 EPA04518.1 - 1.2e-06 28.2 8.3 0.0014 18.6 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 EPA04518.1 - 2.7e-06 27.8 4.5 0.0042 17.6 0.8 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_10 PF13237.6 EPA04518.1 - 1.2e-05 25.3 8.0 0.00027 21.0 8.6 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EPA04518.1 - 1.5e-05 25.0 4.6 8.9e-05 22.6 4.9 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 EPA04518.1 - 8.6e-05 22.7 7.5 0.022 15.2 2.3 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 EPA04518.1 - 0.00016 22.5 3.4 0.28 12.1 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_22 PF17179.4 EPA04518.1 - 0.00092 20.0 2.4 0.43 11.4 0.5 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_15 PF13459.6 EPA04518.1 - 0.0019 18.9 10.5 0.0072 17.0 2.6 2.3 1 1 1 2 2 2 1 4Fe-4S single cluster domain Fer4_8 PF13183.6 EPA04518.1 - 0.0023 18.3 5.7 0.025 15.0 5.9 2.0 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_3 PF12798.7 EPA04518.1 - 0.0032 18.3 10.4 0.098 13.6 3.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EPA04518.1 - 0.028 15.0 7.5 1.2 9.7 7.6 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 EPA04518.1 - 0.59 10.4 9.7 1.4 9.2 2.5 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain TSP_3 PF02412.18 EPA04519.1 - 3.2e-29 100.3 96.6 2.8e-05 23.7 2.8 12.5 10 4 2 12 12 12 8 Thrombospondin type 3 repeat DUF282 PF03380.14 EPA04519.1 - 0.0076 16.2 14.8 14 5.7 0.1 7.5 8 0 0 8 8 8 2 Caenorhabditis protein of unknown function, DUF282 ChitinaseA_N PF08329.10 EPA04519.1 - 0.0091 15.7 2.7 0.61 9.7 0.2 2.8 2 0 0 2 2 2 2 Chitinase A, N-terminal domain AKAP7_RIRII_bdg PF10470.9 EPA04519.1 - 0.2 11.8 0.4 39 4.4 0.0 3.5 4 0 0 4 4 4 0 PKA-RI-RII subunit binding domain of A-kinase anchor protein RIO1 PF01163.22 EPA04520.1 - 1.5e-10 41.0 0.0 2e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EPA04520.1 - 1e-08 34.8 0.1 7.5e-08 32.0 0.1 2.0 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EPA04520.1 - 2.4e-07 30.4 1.0 2.9e-07 30.1 1.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EPA04520.1 - 7.6e-06 26.0 0.0 0.033 14.1 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 EPA04520.1 - 0.00038 19.8 0.5 0.0013 18.1 0.0 2.0 1 1 1 2 2 2 1 Protein tyrosine kinase WaaY PF06176.11 EPA04520.1 - 0.0011 18.6 1.5 0.0019 17.8 1.4 1.6 1 1 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) DUF1679 PF07914.11 EPA04520.1 - 0.0061 15.5 0.1 0.0098 14.8 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) PIF6 PF05341.11 EPA04520.1 - 0.092 12.9 0.1 1.8 8.7 0.0 2.5 2 1 1 3 3 3 0 Per os infectivity factor 6 Rieske PF00355.26 EPA04522.1 - 2.4e-06 27.4 0.0 3.4e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain TAT_signal PF10518.9 EPA04522.1 - 5.3e-05 22.9 1.0 5.3e-05 22.9 1.0 1.6 2 0 0 2 2 2 1 TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N PF10399.9 EPA04522.1 - 0.0016 17.7 0.1 0.0034 16.7 0.1 1.5 1 0 0 1 1 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal AAA_18 PF13238.6 EPA04523.1 - 1.3e-10 41.9 0.3 2.9e-10 40.8 0.1 1.7 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EPA04523.1 - 0.00046 20.6 0.0 0.0014 19.1 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.10 EPA04523.1 - 0.0074 15.8 0.2 0.014 14.9 0.1 1.6 1 1 0 1 1 1 1 Chromatin associated protein KTI12 NTPase_1 PF03266.15 EPA04523.1 - 0.0082 16.1 1.7 0.016 15.1 0.1 2.2 2 2 0 2 2 2 1 NTPase Cytidylate_kin2 PF13189.6 EPA04523.1 - 0.013 15.6 0.0 0.32 11.1 0.0 2.2 1 1 1 2 2 2 0 Cytidylate kinase-like family Sulfotransfer_1 PF00685.27 EPA04523.1 - 0.029 13.8 0.0 0.03 13.8 0.0 1.1 1 0 0 1 1 1 0 Sulfotransferase domain Cytidylate_kin PF02224.18 EPA04523.1 - 0.033 13.9 0.1 0.25 11.1 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase CoaE PF01121.20 EPA04523.1 - 0.044 13.5 0.1 0.1 12.3 0.0 1.7 2 0 0 2 2 2 0 Dephospho-CoA kinase AAA_17 PF13207.6 EPA04523.1 - 0.05 14.0 0.1 0.096 13.1 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EPA04523.1 - 0.071 13.5 0.0 0.071 13.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 EPA04523.1 - 0.08 12.9 0.0 0.18 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EPA04523.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.6 EPA04523.1 - 0.16 12.2 0.0 0.91 9.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain Ham1p_like PF01725.16 EPA04524.1 - 1.4e-41 142.5 0.0 1.6e-41 142.3 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Copper-bind PF00127.20 EPA04525.1 - 1.1e-09 38.6 0.0 1.3e-09 38.4 0.0 1.0 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 EPA04525.1 - 1.2e-05 25.4 0.0 1.7e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain DHHA1 PF02272.19 EPA04526.1 - 7e-12 45.9 0.1 7.6e-12 45.8 0.1 1.1 1 0 0 1 1 1 1 DHHA1 domain MethyltransfD12 PF02086.15 EPA04528.1 - 1.2e-17 64.4 0.1 1.4e-17 64.3 0.1 1.0 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Cons_hypoth95 PF03602.15 EPA04528.1 - 0.15 11.7 1.0 0.3 10.7 0.3 1.8 1 1 1 2 2 2 0 Conserved hypothetical protein 95 RNA_binding PF01877.17 EPA04529.1 - 7e-27 94.1 4.6 8.6e-27 93.8 4.6 1.1 1 0 0 1 1 1 1 RNA binding TSP_3 PF02412.18 EPA04530.1 - 7.6e-06 25.5 10.1 0.0017 18.0 0.1 3.9 4 0 0 4 4 4 2 Thrombospondin type 3 repeat P-II PF00543.22 EPA04532.1 - 2.4e-12 47.3 3.7 2.8e-12 47.1 3.7 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II TSP_3 PF02412.18 EPA04533.1 - 4.8e-16 58.2 46.5 0.00038 20.1 0.8 8.0 7 2 1 8 8 8 5 Thrombospondin type 3 repeat Erv26 PF04148.13 EPA04534.1 - 0.056 13.3 0.2 0.06 13.2 0.2 1.3 1 1 0 1 1 1 0 Transmembrane adaptor Erv26 DUF5433 PF17498.2 EPA04534.1 - 0.17 12.1 1.6 0.22 11.7 0.3 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5433) AsnC_trans_reg PF01037.21 EPA04535.1 - 2.9e-20 72.0 0.3 8.2e-10 38.5 0.0 2.2 2 0 0 2 2 2 2 Lrp/AsnC ligand binding domain NapD PF03927.13 EPA04535.1 - 1.9e-07 31.0 1.0 0.0013 18.8 0.1 3.0 2 1 0 2 2 2 2 NapD protein GYD PF08734.11 EPA04535.1 - 0.00041 20.2 0.0 0.44 10.5 0.0 2.3 2 0 0 2 2 2 2 GYD domain Tn916-Xis PF09035.10 EPA04535.1 - 0.012 15.7 0.0 0.029 14.6 0.0 1.7 1 0 0 1 1 1 0 Excisionase from transposon Tn916 PMT2_N PF17987.1 EPA04535.1 - 0.032 14.4 0.6 0.45 10.7 0.0 2.1 2 0 0 2 2 2 0 Phosphoethanolamine N-methyltransferase 2 N-terminal THF_DHG_CYH PF00763.23 EPA04535.1 - 0.098 12.9 1.0 4.8 7.5 0.1 2.4 1 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain DUF2129 PF09902.9 EPA04535.1 - 0.11 12.6 0.1 22 5.2 0.0 2.9 2 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2129) Ferritin PF00210.24 EPA04535.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Ferritin-like domain Cytochrome_CBB3 PF13442.6 EPA04535.1 - 0.17 12.3 0.0 0.58 10.5 0.0 1.9 2 1 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III PALP PF00291.25 EPA04536.1 - 1.5e-21 77.1 0.1 9.8e-20 71.1 0.0 3.1 2 1 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme CTP_transf_like PF01467.26 EPA04537.1 - 2.4e-14 53.7 0.0 3.2e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 EPA04537.1 - 0.02 14.8 0.0 0.048 13.5 0.0 1.7 2 0 0 2 2 2 0 FAD synthetase Pantoate_ligase PF02569.15 EPA04537.1 - 0.04 13.1 0.1 0.62 9.2 0.0 2.0 2 0 0 2 2 2 0 Pantoate-beta-alanine ligase DpaA_N PF16924.5 EPA04537.1 - 0.051 13.7 0.1 0.13 12.4 0.0 1.7 2 0 0 2 2 2 0 Dipicolinate synthase subunit A N-terminal domain HTH_IclR PF09339.10 EPA04538.1 - 6e-05 22.8 0.0 0.00026 20.7 0.0 2.0 2 0 0 2 2 2 1 IclR helix-turn-helix domain B12-binding_2 PF02607.17 EPA04538.1 - 8.9e-05 22.8 0.0 0.00015 22.1 0.0 1.3 1 0 0 1 1 1 1 B12 binding domain HTH_29 PF13551.6 EPA04538.1 - 0.0021 18.0 0.0 0.0053 16.7 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn helix HTH_11 PF08279.12 EPA04538.1 - 0.0031 17.4 0.0 0.0067 16.3 0.0 1.6 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.6 EPA04538.1 - 0.0062 16.1 0.0 0.028 14.0 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_23 PF13384.6 EPA04538.1 - 0.0075 16.0 0.0 0.022 14.6 0.0 1.7 2 0 0 2 2 2 1 Homeodomain-like domain MarR PF01047.22 EPA04538.1 - 0.042 13.8 0.0 0.091 12.7 0.0 1.5 1 0 0 1 1 1 0 MarR family CtsR_C PF17727.1 EPA04538.1 - 0.082 13.0 0.1 0.26 11.5 0.0 1.9 2 0 0 2 2 2 0 CtsR C-terminal dimerization domain MarR_2 PF12802.7 EPA04538.1 - 0.097 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_28 PF13518.6 EPA04538.1 - 0.15 12.2 0.0 0.54 10.4 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain NERD PF08378.11 EPA04539.1 - 0.023 15.2 2.7 0.24 11.9 0.3 2.2 1 1 1 2 2 2 0 Nuclease-related domain CHDNT PF08073.12 EPA04539.1 - 0.095 12.7 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 CHDNT (NUC034) domain Pcc1 PF09341.10 EPA04540.1 - 0.00019 21.5 0.0 0.00024 21.2 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 DUF4854 PF16146.5 EPA04540.1 - 0.042 14.2 0.0 0.051 13.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4854) MethyltransfD12 PF02086.15 EPA04541.1 - 4.6e-38 131.4 0.5 5.9e-38 131.0 0.5 1.0 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase DUF2089 PF09862.9 EPA04541.1 - 0.0016 18.5 0.2 0.0042 17.1 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2089) Dus PF01207.17 EPA04542.1 - 1.7e-73 247.4 0.0 2.1e-73 247.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 EPA04542.1 - 3.8e-08 32.9 0.1 5e-06 25.9 0.1 2.2 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase NanE PF04131.14 EPA04542.1 - 4.9e-05 22.6 0.1 0.00016 20.9 0.0 1.8 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase Oxidored_FMN PF00724.20 EPA04542.1 - 0.00077 18.8 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family IMPDH PF00478.25 EPA04542.1 - 0.005 15.9 0.0 0.0074 15.3 0.0 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain MR_MLE_C PF13378.6 EPA04542.1 - 0.0059 16.2 0.0 0.013 15.1 0.0 1.6 1 1 0 1 1 1 1 Enolase C-terminal domain-like His_biosynth PF00977.21 EPA04542.1 - 0.0073 15.8 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Histidine biosynthesis protein FMN_dh PF01070.18 EPA04542.1 - 0.034 13.2 0.0 0.066 12.2 0.0 1.5 1 0 0 1 1 1 0 FMN-dependent dehydrogenase Archaeal_AmoA PF12942.7 EPA04544.1 - 1e-98 328.5 12.5 1.2e-98 328.3 12.5 1.0 1 0 0 1 1 1 1 Archaeal ammonia monooxygenase subunit A (AmoA) HTH_10 PF04967.12 EPA04546.1 - 0.068 13.0 0.0 0.069 13.0 0.0 1.2 1 0 0 1 1 1 0 HTH DNA binding domain DsbD PF02683.15 EPA04547.1 - 6.6e-49 166.7 21.5 7.8e-49 166.4 21.5 1.0 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region DsbD_2 PF13386.6 EPA04547.1 - 3.9e-06 26.9 15.0 6e-06 26.3 15.0 1.3 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region SfLAP PF11139.8 EPA04547.1 - 0.00052 19.5 7.8 0.017 14.6 3.0 2.5 1 1 1 2 2 2 2 Sap, sulfolipid-1-addressing protein Baculo_11_kDa PF06143.11 EPA04547.1 - 0.55 9.8 0.0 0.55 9.8 0.0 2.7 4 0 0 4 4 4 0 Baculovirus 11 kDa family DUF373 PF04123.13 EPA04547.1 - 0.58 9.6 15.7 0.92 8.9 13.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF373) AAA_5 PF07728.14 EPA04548.1 - 1.9e-23 83.0 0.1 2.7e-23 82.5 0.1 1.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EPA04548.1 - 3.7e-13 49.5 0.0 5.2e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 EPA04548.1 - 1.1e-07 32.4 0.0 1.8e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EPA04548.1 - 5.1e-06 26.3 0.0 9.3e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_7 PF12775.7 EPA04548.1 - 5.6e-06 26.0 0.0 9.8e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 EPA04548.1 - 7.7e-06 26.0 0.1 1.2e-05 25.3 0.1 1.3 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EPA04548.1 - 2.2e-05 24.5 0.1 3.2e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EPA04548.1 - 0.0001 22.8 0.1 0.00027 21.4 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain MCM PF00493.23 EPA04548.1 - 0.00057 19.0 0.0 0.00095 18.3 0.0 1.3 1 1 0 1 1 1 1 MCM P-loop domain AAA_6 PF12774.7 EPA04548.1 - 0.00077 18.5 0.0 0.0044 16.0 0.0 1.9 1 1 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region RuvB_N PF05496.12 EPA04548.1 - 0.00082 19.1 0.4 0.06 13.1 0.2 2.8 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EPA04548.1 - 0.0013 19.0 0.0 0.0023 18.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.6 EPA04548.1 - 0.0014 18.8 0.0 0.011 15.9 0.0 2.0 1 1 1 2 2 2 1 Sigma-54 interaction domain AAA_11 PF13086.6 EPA04548.1 - 0.002 18.0 0.0 0.003 17.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EPA04548.1 - 0.0028 17.1 0.0 0.42 10.0 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EPA04548.1 - 0.0031 18.1 0.0 0.0062 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 EPA04548.1 - 0.006 16.8 0.1 0.012 15.9 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 EPA04548.1 - 0.013 15.7 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EPA04548.1 - 0.018 14.8 0.1 0.092 12.5 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_2 PF07724.14 EPA04548.1 - 0.018 15.2 0.5 0.054 13.6 0.5 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) TniB PF05621.11 EPA04548.1 - 0.034 13.6 0.0 0.079 12.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein CbbQ_C PF08406.10 EPA04548.1 - 0.035 14.4 0.0 0.071 13.4 0.0 1.5 1 0 0 1 1 1 0 CbbQ/NirQ/NorQ C-terminal AAA_24 PF13479.6 EPA04548.1 - 0.039 13.7 0.1 0.11 12.2 0.1 1.8 1 1 1 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EPA04548.1 - 0.041 13.8 0.0 0.076 12.9 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 EPA04548.1 - 0.07 13.1 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA12 PF10443.9 EPA04548.1 - 0.073 11.8 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein cobW PF02492.19 EPA04548.1 - 0.079 12.5 0.1 0.14 11.8 0.1 1.4 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EPA04548.1 - 0.084 13.4 0.1 0.17 12.4 0.1 1.6 1 1 0 1 1 1 0 ABC transporter DUF815 PF05673.13 EPA04548.1 - 0.092 11.9 0.0 0.37 9.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 EPA04548.1 - 0.1 12.8 0.0 0.18 11.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain tRNA-synt_2b PF00587.25 EPA04549.1 - 3.8e-37 128.0 0.1 6.8e-37 127.2 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EPA04549.1 - 3e-24 85.3 11.0 6.5e-24 84.2 11.0 1.6 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain TMPIT PF07851.13 EPA04549.1 - 0.43 9.8 5.4 0.23 10.7 3.4 1.5 2 0 0 2 2 2 0 TMPIT-like protein Wzt_C PF14524.6 EPA04550.1 - 0.04 14.0 0.0 0.13 12.3 0.0 1.8 2 0 0 2 2 2 0 Wzt C-terminal domain OapA PF04225.12 EPA04550.1 - 0.052 13.7 0.1 0.17 12.0 0.1 1.9 1 1 0 1 1 1 0 Opacity-associated protein A LysM-like domain FAD_binding_2 PF00890.24 EPA04551.1 - 1e-06 28.1 1.5 0.027 13.6 0.0 2.2 1 1 1 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 EPA04551.1 - 1.4e-05 24.6 0.1 2.5e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EPA04551.1 - 0.00016 21.0 0.6 0.023 13.9 0.0 2.7 2 1 0 2 2 2 1 Thi4 family Trp_halogenase PF04820.14 EPA04551.1 - 0.00027 19.9 0.0 0.0077 15.1 0.0 2.7 3 0 0 3 3 3 1 Tryptophan halogenase FAD_binding_3 PF01494.19 EPA04551.1 - 0.0024 17.2 0.5 0.087 12.1 0.0 2.4 2 1 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EPA04551.1 - 0.0038 16.3 0.1 0.0059 15.7 0.1 1.4 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EPA04551.1 - 0.0046 16.2 0.2 0.012 14.9 0.2 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EPA04551.1 - 0.011 15.4 0.6 2.1 7.8 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EPA04551.1 - 0.033 14.4 0.1 0.15 12.3 0.1 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EPA04551.1 - 0.083 11.6 0.0 0.15 10.8 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein TrkA_N PF02254.18 EPA04551.1 - 0.097 12.9 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Ribosomal_S13_N PF08069.12 EPA04552.1 - 1.3e-26 92.4 0.1 2.3e-26 91.6 0.1 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EPA04552.1 - 1e-11 44.9 0.3 1.6e-11 44.2 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 Nnf1 PF03980.14 EPA04552.1 - 0.12 12.8 0.1 0.24 11.8 0.1 1.5 1 0 0 1 1 1 0 Nnf1 TBP PF00352.21 EPA04553.1 - 1.2e-54 182.2 0.0 9.2e-28 96.0 0.0 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EPA04553.1 - 8e-06 25.9 0.0 0.13 12.4 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Lectin_like PF18560.1 EPA04554.1 - 0.027 14.7 0.1 0.03 14.5 0.1 1.1 1 0 0 1 1 1 0 Lectin like domain ASCH PF04266.14 EPA04555.1 - 2.6e-10 40.8 0.0 3.3e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 ASCH domain zinc_ribbon_6 PF14599.6 EPA04556.1 - 0.022 14.8 3.7 0.053 13.5 3.5 1.8 1 1 1 2 2 2 0 Zinc-ribbon DNA_RNApol_7kD PF03604.13 EPA04556.1 - 0.44 10.3 3.5 1.6 8.5 3.5 1.9 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Eapp_C PF10238.9 EPA04556.1 - 1.3 9.1 10.0 4.9 7.2 10.0 1.8 1 1 0 1 1 1 0 E2F-associated phosphoprotein Monooxygenase_B PF04744.12 EPA04558.1 - 6.9e-09 35.0 0.0 1.6e-08 33.8 0.0 1.5 1 1 0 1 1 1 1 Monooxygenase subunit B protein VWA PF00092.28 EPA04559.1 - 5.3e-07 30.0 0.0 1.1e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EPA04559.1 - 0.011 16.3 0.0 0.03 15.0 0.0 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF3828 PF12883.7 EPA04559.1 - 0.1 13.0 0.0 0.34 11.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3828) Thioredoxin_10 PF17991.1 EPA04561.1 - 1.1e-36 126.5 0.0 1.6e-36 125.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin like C-terminal domain AhpC-TSA PF00578.21 EPA04561.1 - 1.2e-08 35.0 0.1 1.9e-08 34.2 0.1 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EPA04561.1 - 5.6e-08 32.6 0.0 9.7e-08 31.8 0.0 1.4 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 EPA04561.1 - 0.0017 18.7 0.1 0.0033 17.7 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like Gemini_AL1 PF00799.20 EPA04561.1 - 0.084 13.2 0.3 6 7.3 0.1 2.4 2 0 0 2 2 2 0 Geminivirus Rep catalytic domain AsnC_trans_reg PF01037.21 EPA04562.1 - 2.1e-12 46.8 0.1 2.4e-12 46.6 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 EPA04562.1 - 0.013 15.6 0.1 0.015 15.3 0.1 1.1 1 0 0 1 1 1 0 NapD protein COX7C PF02935.16 EPA04563.1 - 0.048 13.9 0.4 0.086 13.1 0.4 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIc AhpC-TSA PF00578.21 EPA04565.1 - 5.7e-20 71.5 0.4 7.1e-20 71.2 0.4 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EPA04565.1 - 4.2e-12 46.0 0.1 5.2e-12 45.7 0.1 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 EPA04565.1 - 1.1e-06 28.9 0.7 1.9e-06 28.1 0.7 1.4 1 0 0 1 1 1 1 Thioredoxin-like T4_deiodinase PF00837.17 EPA04565.1 - 0.0011 18.3 0.1 0.015 14.6 0.0 1.9 1 1 1 2 2 2 1 Iodothyronine deiodinase Thioredoxin_2 PF13098.6 EPA04565.1 - 0.012 16.1 0.1 0.019 15.4 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_3 PF13192.6 EPA04565.1 - 0.017 15.1 0.5 0.13 12.4 0.0 2.2 1 1 1 2 2 2 0 Thioredoxin domain Thioredoxin PF00085.20 EPA04565.1 - 0.071 13.1 0.2 0.6 10.1 0.1 2.1 1 1 1 2 2 2 0 Thioredoxin FixQ PF05545.11 EPA04567.1 - 0.28 11.2 2.1 0.46 10.5 2.1 1.4 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ TSP_3 PF02412.18 EPA04568.1 - 2.3e-11 43.2 31.6 0.00019 21.0 2.2 5.2 6 0 0 6 6 6 3 Thrombospondin type 3 repeat Excalibur PF05901.11 EPA04568.1 - 1.6 9.4 13.3 1.3 9.7 0.4 3.9 4 1 0 4 4 4 0 Excalibur calcium-binding domain DUF3899 PF13038.6 EPA04570.1 - 0.0043 17.5 2.0 0.01 16.3 1.1 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF3899) PIRT PF15099.6 EPA04570.1 - 0.0048 16.5 1.0 0.0074 15.9 1.0 1.4 1 0 0 1 1 1 1 Phosphoinositide-interacting protein family I-set PF07679.16 EPA04570.1 - 0.024 14.7 0.1 0.048 13.7 0.1 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain FlgD_ig PF13860.6 EPA04570.1 - 0.044 13.7 0.9 0.2 11.5 0.8 2.1 1 1 0 1 1 1 0 FlgD Ig-like domain MG2 PF01835.19 EPA04570.1 - 0.096 13.1 0.1 0.24 11.9 0.1 1.7 1 0 0 1 1 1 0 MG2 domain Ribosomal_S3Ae PF01015.18 EPA04571.1 - 2.4e-59 200.3 4.9 2.7e-59 200.1 4.9 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family DHH PF01368.20 EPA04572.1 - 0.0024 18.1 0.1 0.0047 17.1 0.1 1.5 1 0 0 1 1 1 1 DHH family AmoC PF04896.12 EPA04573.1 - 2.4e-13 49.9 6.3 3e-13 49.6 6.3 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C RTA1 PF04479.13 EPA04573.1 - 0.0059 16.2 0.2 0.009 15.6 0.2 1.2 1 0 0 1 1 1 1 RTA1 like protein ETRAMP PF09716.10 EPA04574.1 - 0.23 11.5 0.8 0.38 10.8 0.8 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) zf-AN1 PF01428.16 EPA04575.1 - 4.7e-11 42.7 3.4 5.8e-11 42.4 3.4 1.2 1 0 0 1 1 1 1 AN1-like Zinc finger Pyr_redox_2 PF07992.14 EPA04576.1 - 4.3e-19 68.9 0.0 5.9e-18 65.1 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EPA04576.1 - 0.00016 22.1 3.9 0.22 12.1 0.0 3.8 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EPA04576.1 - 0.0013 18.7 0.0 0.025 14.6 0.0 2.7 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EPA04576.1 - 0.002 18.3 0.0 0.0038 17.4 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EPA04576.1 - 0.033 13.3 0.0 1 8.4 0.0 2.6 3 0 0 3 3 3 0 FAD binding domain Trp_halogenase PF04820.14 EPA04576.1 - 0.04 12.8 0.0 0.057 12.3 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase tRNA_NucTransf2 PF09249.11 EPA04577.1 - 8.3e-38 129.1 0.1 1.6e-37 128.2 0.1 1.5 1 0 0 1 1 1 1 tRNA nucleotidyltransferase, second domain NTP_transf_2 PF01909.23 EPA04577.1 - 1.1e-09 38.4 0.2 3.3e-09 36.9 0.2 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EPA04577.1 - 0.0005 20.1 0.1 0.0018 18.3 0.1 2.0 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase SMODS PF18144.1 EPA04577.1 - 0.0008 19.6 1.5 0.0013 19.0 0.5 1.9 2 0 0 2 2 2 1 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain MCR_alpha PF02249.17 EPA04577.1 - 0.033 14.7 0.0 0.15 12.6 0.0 2.0 1 1 1 2 2 2 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain CLN6 PF15156.6 EPA04579.1 - 0.003 16.9 0.3 0.0036 16.6 0.3 1.2 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 6 B12D PF06522.11 EPA04579.1 - 0.06 13.1 0.9 0.089 12.6 0.0 1.7 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit LptF_LptG PF03739.14 EPA04579.1 - 5.9 5.6 8.1 11 4.8 0.2 2.0 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG His_Me_b4a2 PF18275.1 EPA04580.1 - 0.011 15.8 2.0 0.014 15.5 1.4 1.6 1 1 0 1 1 1 0 His-Me finger endonuclease beta4-alpha2 domain LigT_PEase PF02834.16 EPA04581.1 - 4.2e-23 81.3 0.0 2.3e-12 46.9 0.0 2.1 2 0 0 2 2 2 2 LigT like Phosphoesterase AKAP7_NLS PF10469.9 EPA04581.1 - 6e-13 49.2 0.1 8.8e-13 48.6 0.1 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 EPA04581.1 - 3.8e-09 36.6 0.0 4.6e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily AAA_17 PF13207.6 EPA04583.1 - 3.2e-13 50.3 0.1 3.8e-13 50.0 0.1 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EPA04583.1 - 1e-12 48.7 0.0 1.4e-12 48.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EPA04583.1 - 5e-05 23.5 0.0 8.4e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EPA04583.1 - 0.00038 20.4 0.4 0.19 11.6 0.2 2.2 1 1 1 2 2 2 2 NTPase ADK PF00406.22 EPA04583.1 - 0.0017 18.5 0.1 0.002 18.2 0.1 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_28 PF13521.6 EPA04583.1 - 0.0023 18.2 0.0 0.0028 17.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain CoaE PF01121.20 EPA04583.1 - 0.0032 17.2 0.1 0.0053 16.4 0.1 1.3 1 1 0 1 1 1 1 Dephospho-CoA kinase APS_kinase PF01583.20 EPA04583.1 - 0.0037 17.2 0.0 0.015 15.2 0.0 1.8 2 0 0 2 2 2 1 Adenylylsulphate kinase Zeta_toxin PF06414.12 EPA04583.1 - 0.0037 16.5 0.1 0.0074 15.6 0.0 1.5 2 0 0 2 2 2 1 Zeta toxin AAA_14 PF13173.6 EPA04583.1 - 0.0039 17.2 0.0 0.0054 16.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EPA04583.1 - 0.0052 16.3 0.1 0.013 15.0 0.0 1.7 1 1 1 2 2 2 1 Chromatin associated protein KTI12 MeaB PF03308.16 EPA04583.1 - 0.0066 15.5 0.0 0.0087 15.1 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Hpr_kinase_C PF07475.12 EPA04583.1 - 0.0094 15.5 0.0 0.022 14.3 0.0 1.5 1 1 0 1 1 1 1 HPr Serine kinase C-terminal domain NB-ARC PF00931.22 EPA04583.1 - 0.01 15.0 0.0 0.01 15.0 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.6 EPA04583.1 - 0.011 15.4 0.2 0.02 14.6 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 EPA04583.1 - 0.017 15.5 0.2 0.028 14.9 0.2 1.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) UPF0180 PF03698.13 EPA04583.1 - 0.025 14.7 0.0 0.18 12.0 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) AAA_22 PF13401.6 EPA04583.1 - 0.03 14.6 0.3 0.07 13.4 0.3 1.8 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EPA04583.1 - 0.046 14.2 0.5 0.065 13.7 0.5 1.6 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EPA04583.1 - 0.069 13.5 0.1 0.13 12.6 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain Ploopntkinase3 PF18751.1 EPA04583.1 - 0.09 12.7 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 Viral_helicase1 PF01443.18 EPA04583.1 - 0.098 12.4 0.0 0.11 12.2 0.0 1.3 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 EPA04583.1 - 0.1 12.3 0.2 0.12 12.1 0.2 1.5 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EPA04583.1 - 0.1 12.6 0.1 0.4 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) P-mevalo_kinase PF04275.14 EPA04583.1 - 0.12 12.4 0.1 0.34 10.9 0.1 1.8 1 1 0 1 1 1 0 Phosphomevalonate kinase adh_short PF00106.25 EPA04584.1 - 2.1e-61 206.8 1.7 2.8e-61 206.4 1.7 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EPA04584.1 - 2.9e-48 164.5 1.8 3.6e-48 164.2 1.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EPA04584.1 - 1e-13 51.6 0.2 1.6e-13 50.9 0.1 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EPA04584.1 - 0.0056 16.2 0.6 0.38 10.2 0.6 2.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EPA04584.1 - 0.021 14.1 2.8 0.39 10.0 0.0 2.6 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Cullin PF00888.22 EPA04584.1 - 0.028 13.1 0.1 0.04 12.5 0.1 1.2 1 0 0 1 1 1 0 Cullin family Eno-Rase_NADH_b PF12242.8 EPA04584.1 - 0.11 12.2 1.0 0.3 10.9 1.0 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase BRCT_2 PF16589.5 EPA04584.1 - 0.14 12.6 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain F420_oxidored PF03807.17 EPA04584.1 - 0.21 12.2 2.5 0.66 10.6 0.2 2.3 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Pkinase PF00069.25 EPA04585.1 - 9.6e-06 25.2 0.9 1.4e-05 24.6 0.4 1.5 1 1 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 EPA04585.1 - 8.3e-05 22.3 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 EPA04585.1 - 0.00036 20.2 0.0 0.12 12.0 0.0 2.6 1 1 1 2 2 2 2 Choline/ethanolamine kinase Ca_bind_SSO6904 PF18249.1 EPA04586.1 - 0.00058 20.2 1.3 0.00094 19.5 0.8 1.7 1 1 0 1 1 1 1 Calcium binding protein SSO6904 Tox-PLDMTX PF15645.6 EPA04586.1 - 0.037 14.3 0.6 0.38 11.0 0.2 2.1 1 1 1 2 2 2 0 Dermonecrotoxin of the Papain-like fold Pterin_4a PF01329.19 EPA04587.1 - 7.5e-33 112.6 0.2 8.1e-33 112.5 0.2 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase IF-2 PF11987.8 EPA04587.1 - 0.036 14.2 0.1 0.062 13.4 0.1 1.5 1 1 0 1 1 1 0 Translation-initiation factor 2 Usp PF00582.26 EPA04588.1 - 0.69 10.4 3.2 0.41 11.1 0.2 2.1 2 0 0 2 2 2 0 Universal stress protein family Lyase_1 PF00206.20 EPA04589.1 - 3e-49 168.1 1.4 4.8e-49 167.4 1.4 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EPA04589.1 - 3.7e-14 53.0 0.0 8.7e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus ASL_C PF08328.11 EPA04589.1 - 0.0072 16.4 0.0 0.02 15.0 0.0 1.7 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminal PTPS PF01242.19 EPA04590.1 - 6.1e-10 39.1 0.0 7.4e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase PIG-P PF08510.12 EPA04591.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 PIG-P FAA_hydro_N_2 PF18288.1 EPA04593.1 - 0.067 13.6 0.0 0.097 13.1 0.0 1.5 1 1 0 1 1 1 0 Fumarylacetoacetase N-terminal domain 2 AIRS PF00586.24 EPA04594.1 - 2.5e-13 50.5 0.0 6.4e-13 49.2 0.0 1.7 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain AIRS_C PF02769.22 EPA04594.1 - 0.00021 21.5 0.0 0.00042 20.5 0.0 1.5 1 1 0 1 1 1 1 AIR synthase related protein, C-terminal domain PGM_PMM_I PF02878.16 EPA04595.1 - 1.7e-23 82.9 0.0 4.3e-23 81.5 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EPA04595.1 - 5.6e-15 55.5 0.1 4.3e-14 52.7 0.0 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EPA04595.1 - 3.8e-12 46.7 0.0 1e-11 45.4 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EPA04595.1 - 1.2e-06 28.6 0.1 3.8e-06 27.0 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Ribosomal_S11 PF00411.19 EPA04596.1 - 1.2e-41 141.6 1.9 1.5e-41 141.2 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 EPA04596.1 - 0.041 14.1 0.1 0.08 13.2 0.1 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) dsDNA_bind PF01984.20 EPA04599.1 - 2.9e-06 27.5 0.5 3.6e-06 27.2 0.5 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain EF-1_beta_acid PF10587.9 EPA04599.1 - 0.0031 17.9 1.7 0.0063 16.9 1.7 1.5 1 0 0 1 1 1 1 Eukaryotic elongation factor 1 beta central acidic region DDRGK PF09756.9 EPA04599.1 - 0.4 10.2 3.6 1.5 8.4 3.5 2.0 1 1 0 1 1 1 0 DDRGK domain tRNA-synt_1 PF00133.22 EPA04600.1 - 1.3e-105 353.9 1.1 2.4e-104 349.8 1.1 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EPA04600.1 - 4.9e-31 107.8 2.9 4.9e-31 107.8 2.9 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EPA04600.1 - 4.4e-22 78.4 4.2 8.7e-12 44.5 0.0 3.2 2 1 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EPA04600.1 - 0.00051 19.6 1.1 0.1 12.1 0.0 3.1 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 PAS_7 PF12860.7 EPA04601.1 - 0.1 12.8 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 PAS fold Asn_synthase PF00733.21 EPA04602.1 - 1.1e-26 94.4 0.0 1.6e-20 74.1 0.0 2.0 1 1 1 2 2 2 2 Asparagine synthase NAD_synthase PF02540.17 EPA04602.1 - 1.8e-06 27.3 0.4 5.4e-06 25.7 0.1 1.9 2 0 0 2 2 2 1 NAD synthase QueC PF06508.13 EPA04602.1 - 0.00038 20.0 0.1 0.00092 18.8 0.1 1.7 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC RE_CfrBI PF09516.10 EPA04602.1 - 0.009 15.5 0.2 0.021 14.2 0.0 1.7 2 1 0 2 2 2 1 CfrBI restriction endonuclease PI31_Prot_N PF11566.8 EPA04602.1 - 0.051 13.4 0.1 0.25 11.1 0.0 2.1 2 0 0 2 2 2 0 PI31 proteasome regulator N-terminal Apolipoprotein PF01442.18 EPA04603.1 - 0.001 18.9 1.9 0.0018 18.2 1.9 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain LicD PF04991.13 EPA04603.1 - 0.025 14.7 6.1 0.042 14.0 6.1 1.3 1 0 0 1 1 1 0 LicD family OmpH PF03938.14 EPA04603.1 - 0.046 14.1 8.7 0.074 13.4 8.7 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Cytidylate_kin2 PF13189.6 EPA04603.1 - 0.49 10.5 3.7 5.3 7.1 0.0 2.3 1 1 0 2 2 2 0 Cytidylate kinase-like family FapA PF03961.13 EPA04603.1 - 5.8 5.4 13.4 7.8 5.0 12.6 1.7 1 1 0 1 1 1 0 Flagellar Assembly Protein A TMPIT PF07851.13 EPA04603.1 - 8.4 5.5 6.9 11 5.1 6.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein RtcB PF01139.17 EPA04605.1 - 3.9e-166 553.3 0.1 4.5e-166 553.1 0.1 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Complex1_LYR PF05347.15 EPA04605.1 - 0.022 14.8 0.1 0.061 13.4 0.1 1.7 1 0 0 1 1 1 0 Complex 1 protein (LYR family) GATase PF00117.28 EPA04606.1 - 6.6e-25 88.0 0.0 7.4e-25 87.8 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EPA04606.1 - 2.6e-05 24.1 0.1 0.0014 18.4 0.1 2.7 1 1 0 1 1 1 1 Peptidase C26 SNO PF01174.19 EPA04606.1 - 0.00013 21.9 0.0 0.0011 18.8 0.0 1.9 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 EPA04606.1 - 0.0011 18.6 0.0 0.0016 18.1 0.0 1.5 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain IGPD PF00475.18 EPA04607.1 - 6.8e-27 94.5 0.0 7.7e-27 94.4 0.0 1.0 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase ANF_receptor PF01094.28 EPA04607.1 - 0.023 13.8 0.0 0.027 13.6 0.0 1.1 1 0 0 1 1 1 0 Receptor family ligand binding region His_biosynth PF00977.21 EPA04608.1 - 1.5e-38 132.6 0.1 1.6e-38 132.5 0.1 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Mitovir_RNA_pol PF05919.11 EPA04608.1 - 0.096 11.8 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 Mitovirus RNA-dependent RNA polymerase zinc_ribbon_4 PF13717.6 EPA04610.1 - 0.046 13.7 0.9 0.7 9.9 0.3 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-AN1 PF01428.16 EPA04610.1 - 0.94 9.7 7.0 9.2 6.5 2.2 2.6 2 1 0 2 2 2 0 AN1-like Zinc finger Cep57_MT_bd PF06657.13 EPA04615.1 - 0.024 15.1 2.8 0.024 15.1 2.8 1.8 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 APG6_N PF17675.1 EPA04615.1 - 0.057 14.0 3.9 0.071 13.6 3.9 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region eIF3_subunit PF08597.10 EPA04615.1 - 0.069 13.1 7.6 0.082 12.8 7.6 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit TMPIT PF07851.13 EPA04615.1 - 0.83 8.8 4.8 1 8.6 4.8 1.0 1 0 0 1 1 1 0 TMPIT-like protein ELK PF03789.13 EPA04615.1 - 1.3 9.2 0.0 1.3 9.2 0.0 3.1 4 0 0 4 4 4 0 ELK domain Fe-ADH PF00465.19 EPA04616.1 - 2.4e-49 168.1 0.0 5.5e-49 166.9 0.0 1.6 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EPA04616.1 - 1.4e-17 64.3 0.0 2e-17 63.8 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 EPA04616.1 - 0.0014 17.8 0.0 0.27 10.4 0.0 2.3 2 0 0 2 2 2 2 3-dehydroquinate synthase Pyridox_ox_2 PF12900.7 EPA04617.1 - 1.1e-22 80.6 0.0 1.2e-22 80.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 EPA04617.1 - 6.9e-14 51.8 0.0 2e-13 50.3 0.0 1.7 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 EPA04617.1 - 8.1e-05 22.2 0.0 0.11 12.1 0.0 2.0 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase like FMN_bind_2 PF04299.12 EPA04617.1 - 0.002 17.9 0.0 0.0023 17.6 0.0 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain DUF4147 PF13660.6 EPA04618.1 - 4e-67 226.1 0.0 5.3e-67 225.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) MOFRL PF05161.13 EPA04618.1 - 1.4e-18 67.1 0.9 1.4e-17 63.8 0.7 2.3 2 0 0 2 2 2 1 MOFRL family Bac_luciferase PF00296.20 EPA04619.1 - 6.3e-54 183.5 0.0 8.4e-54 183.1 0.0 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase RNA_pol_Rpc34 PF05158.12 EPA04620.1 - 0.017 14.5 0.3 0.017 14.5 0.3 1.4 2 0 0 2 2 2 0 RNA polymerase Rpc34 subunit Nop53 PF07767.11 EPA04621.1 - 0.047 13.1 1.4 0.057 12.8 1.4 1.3 1 1 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) LOH1CR12 PF10158.9 EPA04621.1 - 0.065 13.3 2.9 0.081 12.9 2.1 1.5 1 1 0 1 1 1 0 Tumour suppressor protein FliS PF02561.14 EPA04621.1 - 0.071 13.4 1.4 0.086 13.1 1.4 1.1 1 0 0 1 1 1 0 Flagellar protein FliS SNARE_assoc PF09335.11 EPA04622.1 - 3e-21 76.1 2.2 3.5e-21 75.9 1.6 1.4 1 1 0 1 1 1 1 SNARE associated Golgi protein MRP-S23 PF10484.9 EPA04623.1 - 2.2 8.6 9.4 0.26 11.6 1.8 2.7 1 1 2 3 3 3 0 Mitochondrial ribosomal protein S23 Eno-Rase_FAD_bd PF07055.12 EPA04624.1 - 0.031 14.7 0.6 9.2 6.8 0.0 2.4 1 1 1 2 2 2 0 Enoyl reductase FAD binding domain 7TMR-HDED PF07697.11 EPA04624.1 - 0.11 12.6 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 7TM-HD extracellular DUF682 PF05081.12 EPA04625.1 - 0.036 13.8 0.0 0.07 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF682) PALP PF00291.25 EPA04626.1 - 2.4e-47 161.7 0.0 3.1e-47 161.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme 4HPAD_g_N PF18671.1 EPA04626.1 - 0.35 10.6 2.0 2 8.2 0.1 2.6 3 0 0 3 3 3 0 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal Hjc PF01870.18 EPA04627.1 - 0.00018 21.5 0.0 0.00029 20.8 0.0 1.5 1 0 0 1 1 1 1 Archaeal holliday junction resolvase (hjc) R-HINP1I PF11463.8 EPA04627.1 - 0.044 13.2 0.2 0.063 12.7 0.2 1.2 1 0 0 1 1 1 0 R.HinP1I restriction endonuclease AsnC_trans_reg PF01037.21 EPA04628.1 - 0.01 15.7 0.3 0.013 15.4 0.3 1.2 1 0 0 1 1 1 0 Lrp/AsnC ligand binding domain DivIC PF04977.15 EPA04629.1 - 0.031 14.0 0.3 0.055 13.2 0.3 1.4 1 0 0 1 1 1 0 Septum formation initiator DUF2085 PF09858.9 EPA04630.1 - 0.34 11.4 3.2 0.13 12.8 0.7 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2085) NatB_MDM20 PF09797.9 EPA04633.1 - 0.066 12.1 0.1 0.068 12.1 0.1 1.0 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit Ribonuc_red_2_N PF08471.10 EPA04633.1 - 0.068 13.4 0.2 0.069 13.3 0.2 1.1 1 0 0 1 1 1 0 Class II vitamin B12-dependent ribonucleotide reductase Thiolase_C PF02803.18 EPA04635.1 - 1.1e-12 47.6 1.0 2.4e-12 46.6 0.2 2.0 2 1 1 3 3 3 1 Thiolase, C-terminal domain Thiolase_N PF00108.23 EPA04635.1 - 1.2e-08 34.7 2.9 9e-08 31.8 0.5 2.6 2 1 0 2 2 2 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.26 EPA04635.1 - 0.00011 21.9 0.1 0.00029 20.5 0.0 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Dodecin PF07311.12 EPA04635.1 - 0.00065 19.9 0.4 0.0014 18.8 0.4 1.5 1 0 0 1 1 1 1 Dodecin Ketoacyl-synt_C PF02801.22 EPA04635.1 - 0.00067 19.7 0.7 0.37 10.8 0.2 2.5 2 0 0 2 2 2 2 Beta-ketoacyl synthase, C-terminal domain ACP_syn_III PF08545.10 EPA04635.1 - 0.012 15.5 0.0 0.034 14.0 0.0 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Guanylate_cyc PF00211.20 EPA04636.1 - 4.9e-16 58.9 0.0 6.9e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DapB_N PF01113.20 EPA04638.1 - 9.2e-05 22.6 0.0 0.00016 21.8 0.0 1.4 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_3 PF03447.16 EPA04638.1 - 0.004 17.8 0.0 0.0055 17.4 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 EPA04638.1 - 0.0092 16.4 0.0 0.011 16.2 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Gp_dh_N PF00044.24 EPA04638.1 - 0.031 14.6 0.0 0.052 13.9 0.0 1.6 1 1 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain IlvN PF07991.12 EPA04638.1 - 0.12 12.0 0.0 0.2 11.2 0.0 1.4 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain CbiK PF06180.11 EPA04639.1 - 0.036 13.4 0.0 0.16 11.2 0.0 1.8 1 1 1 2 2 2 0 Cobalt chelatase (CbiK) AIRC PF00731.20 EPA04640.1 - 1.7e-58 196.4 0.1 2.4e-58 195.9 0.1 1.2 1 0 0 1 1 1 1 AIR carboxylase PrpR_N PF06506.11 EPA04640.1 - 0.014 15.0 0.3 0.092 12.3 0.0 2.3 2 1 1 3 3 3 0 Propionate catabolism activator Asp_Glu_race PF01177.22 EPA04640.1 - 0.058 13.2 0.0 0.11 12.3 0.0 1.4 2 0 0 2 2 2 0 Asp/Glu/Hydantoin racemase NTP_transferase PF00483.23 EPA04641.1 - 2.2e-32 112.6 0.4 3.1e-32 112.1 0.4 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EPA04641.1 - 1.2e-11 45.3 0.0 1.7e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 EPA04641.1 - 0.001 18.9 0.0 0.0036 17.1 0.0 1.9 1 1 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CspB_prodomain PF18425.1 EPA04641.1 - 0.089 12.8 2.3 1.2 9.2 0.1 2.3 2 0 0 2 2 2 0 Csp protease B prodomain DUF21 PF01595.20 EPA04644.1 - 6.5e-49 166.0 0.9 1e-48 165.4 0.9 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CorC_HlyC PF03471.17 EPA04644.1 - 3.3e-17 62.3 0.5 3.3e-17 62.3 0.5 1.7 2 0 0 2 2 2 1 Transporter associated domain CBS PF00571.28 EPA04644.1 - 5.6e-15 55.5 0.9 8.3e-06 26.2 0.1 3.3 3 0 0 3 3 3 2 CBS domain Glycos_transf_2 PF00535.26 EPA04646.1 - 8.8e-35 120.0 0.1 1.6e-34 119.1 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EPA04646.1 - 1.4e-32 113.5 0.0 1.9e-32 113.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EPA04646.1 - 8.1e-23 81.4 0.0 8.1e-23 81.4 0.0 1.8 2 0 0 2 2 1 1 Glycosyl transferase family group 2 Chitin_synth_2 PF03142.15 EPA04646.1 - 3.6e-12 45.7 0.2 1.3e-08 33.9 0.0 3.3 2 1 0 3 3 3 2 Chitin synthase Glyco_transf_21 PF13506.6 EPA04646.1 - 2.2e-11 43.5 0.0 3.6e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 EPA04646.1 - 2.4e-10 40.3 0.2 6.4e-10 39.0 0.1 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 EPA04646.1 - 0.0048 17.4 0.0 0.014 15.8 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferase family 2 SpaA PF17802.1 EPA04646.1 - 0.1 12.9 0.7 1.2 9.5 0.1 2.9 2 0 0 2 2 2 0 Prealbumin-like fold domain DUF4519 PF15012.6 EPA04646.1 - 0.12 12.6 2.9 0.19 11.9 0.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) Orf78 PF06024.12 EPA04646.1 - 0.43 10.9 5.4 0.3 11.4 0.5 2.7 2 0 0 2 2 2 0 Orf78 (ac78) DUF3899 PF13038.6 EPA04646.1 - 1.2 9.7 4.6 4.4 7.9 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3899) DZR PF12773.7 EPA04647.1 - 0.021 14.8 5.3 0.087 12.9 5.3 1.8 1 1 0 1 1 1 0 Double zinc ribbon LIM PF00412.22 EPA04647.1 - 0.11 12.7 8.1 0.14 12.4 8.1 1.1 1 0 0 1 1 1 0 LIM domain Pox_A3L PF05288.11 EPA04647.1 - 0.41 10.7 4.5 1.1 9.2 0.1 2.0 1 1 1 2 2 2 0 Poxvirus A3L Protein DUF35_N PF12172.8 EPA04648.1 - 4.4e-05 23.3 0.0 7.5e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Rubredoxin-like zinc ribbon domain (DUF35_N) DZR PF12773.7 EPA04648.1 - 0.058 13.4 1.7 0.12 12.4 1.7 1.5 1 1 0 1 1 1 0 Double zinc ribbon Bac_luciferase PF00296.20 EPA04649.1 - 3.5e-58 197.5 0.0 4.2e-58 197.2 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase AsnC_trans_reg PF01037.21 EPA04651.1 - 5.4e-07 29.5 0.0 5.9e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain PALP PF00291.25 EPA04652.1 - 2.6e-85 286.4 0.3 4e-85 285.8 0.3 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACT PF01842.25 EPA04652.1 - 0.00023 20.9 0.1 0.00058 19.6 0.1 1.6 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 EPA04652.1 - 0.00051 20.6 0.2 0.0014 19.2 0.2 1.7 1 0 0 1 1 1 1 ACT domain Thr_dehydrat_C PF00585.18 EPA04652.1 - 0.0012 18.6 0.0 0.012 15.4 0.0 2.4 2 0 0 2 2 2 1 C-terminal regulatory domain of Threonine dehydratase Peripla_BP_4 PF13407.6 EPA04652.1 - 0.028 14.0 0.5 4.8 6.7 0.2 2.5 2 1 0 2 2 2 0 Periplasmic binding protein domain Glyoxalase_2 PF12681.7 EPA04653.1 - 1e-08 35.1 0.0 1.3e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 EPA04653.1 - 5.3e-08 33.1 0.0 1.2e-07 31.9 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EPA04653.1 - 0.0015 19.3 0.0 0.0018 19.0 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 EPA04653.1 - 0.0036 17.6 0.0 0.11 12.7 0.0 2.1 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Dak1 PF02733.17 EPA04654.1 - 0.044 12.7 0.2 0.05 12.5 0.2 1.0 1 0 0 1 1 1 0 Dak1 domain CBFB_NFYA PF02045.15 EPA04654.1 - 0.073 13.7 0.0 0.073 13.7 0.0 1.2 1 0 0 1 1 1 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B ATP-grasp PF02222.22 EPA04655.1 - 1.2e-57 194.2 0.0 1.8e-57 193.6 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 EPA04655.1 - 2.5e-12 46.3 0.0 5.3e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 EPA04655.1 - 5.9e-07 29.2 0.0 1.6e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EPA04655.1 - 0.00011 22.3 0.1 0.00024 21.2 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain 2-Hacid_dh_C PF02826.19 EPA04655.1 - 0.0025 17.2 0.0 0.0047 16.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1297 PF06973.12 EPA04655.1 - 0.022 14.3 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1297) GIT1_C PF12205.8 EPA04656.1 - 0.002 18.2 0.3 0.0025 17.9 0.3 1.1 1 0 0 1 1 1 1 G protein-coupled receptor kinase-interacting protein 1 C term YtxH PF12732.7 EPA04656.1 - 0.024 15.2 0.7 0.1 13.2 0.0 1.9 2 0 0 2 2 2 0 YtxH-like protein IFT20 PF14931.6 EPA04656.1 - 0.047 13.9 1.6 1.2 9.3 0.1 2.1 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 Peptidase_S8 PF00082.22 EPA04657.1 - 2.2e-17 63.3 1.0 1.2e-16 60.9 0.0 2.1 2 0 0 2 2 2 1 Subtilase family fn3_5 PF06280.12 EPA04657.1 - 2.6e-05 24.9 0.3 0.0022 18.7 0.0 2.9 2 0 0 2 2 2 1 Fn3-like domain DUF916 PF06030.12 EPA04657.1 - 0.032 14.3 2.8 7.5 6.6 0.0 3.6 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF916) Peptidase_S8 PF00082.22 EPA04658.1 - 4.1e-16 59.1 0.0 8.3e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EPA04658.1 - 9.8e-06 26.2 0.6 0.00032 21.3 0.0 2.6 2 0 0 2 2 2 1 Fn3-like domain DUF916 PF06030.12 EPA04658.1 - 0.00018 21.5 0.1 1.6 8.8 0.0 3.2 3 0 0 3 3 3 2 Bacterial protein of unknown function (DUF916) DUF1297 PF06973.12 EPA04659.1 - 7.4e-12 45.2 0.1 7.7e-12 45.1 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) zf-FPG_IleRS PF06827.14 EPA04660.1 - 0.024 14.5 1.0 0.54 10.2 0.1 2.2 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf-trcl PF13451.6 EPA04660.1 - 0.033 14.1 2.0 1.2 9.0 0.4 2.2 2 0 0 2 2 2 0 Probable zinc-ribbon domain Lar_restr_allev PF14354.6 EPA04660.1 - 0.034 14.5 0.1 0.044 14.2 0.1 1.2 1 0 0 1 1 1 0 Restriction alleviation protein Lar Cys_rich_KTR PF14205.6 EPA04660.1 - 0.16 11.8 2.3 0.27 11.0 2.3 1.5 1 1 0 1 1 1 0 Cysteine-rich KTR zf-CCHC_5 PF14787.6 EPA04660.1 - 0.99 9.2 3.9 1.8 8.3 1.0 2.2 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger HhH-GPD PF00730.25 EPA04662.1 - 1.4e-24 86.6 0.1 2e-24 86.1 0.1 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EPA04662.1 - 8.8e-09 34.8 0.0 2.4e-08 33.4 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EPA04662.1 - 0.0025 18.4 0.9 0.46 11.1 0.1 2.3 1 1 1 2 2 2 2 Helix-hairpin-helix domain DUF2400 PF09674.10 EPA04662.1 - 0.0033 17.5 0.1 0.014 15.4 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2400) AGOG PF09171.10 EPA04662.1 - 0.005 16.2 1.7 0.017 14.4 1.7 1.8 1 1 0 1 1 1 1 N-glycosylase/DNA lyase HHH_2 PF12826.7 EPA04662.1 - 0.022 14.9 0.0 2.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif HhH-GPD PF00730.25 EPA04663.1 - 9.3e-25 87.2 0.1 1.3e-24 86.7 0.1 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EPA04663.1 - 1.1e-08 34.5 0.0 2.4e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EPA04663.1 - 0.0025 18.4 0.7 0.46 11.1 0.1 2.3 1 1 1 2 2 2 2 Helix-hairpin-helix domain DUF2400 PF09674.10 EPA04663.1 - 0.0039 17.2 0.1 0.018 15.1 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2400) AGOG PF09171.10 EPA04663.1 - 0.0095 15.3 2.5 0.042 13.2 2.5 1.9 1 1 0 1 1 1 1 N-glycosylase/DNA lyase HHH_2 PF12826.7 EPA04663.1 - 0.014 15.5 0.0 2.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 EPA04663.1 - 1.7 9.1 4.0 2.9 8.4 4.0 1.4 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III Copper-bind PF00127.20 EPA04664.1 - 9.8e-18 64.4 2.1 3.6e-09 37.0 0.2 2.5 2 0 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 EPA04664.1 - 3.1e-14 52.9 0.0 6.7e-06 26.2 0.0 2.6 2 0 0 2 2 2 2 Cupredoxin-like domain TonB_N PF16031.5 EPA04664.1 - 0.59 10.6 29.4 0.06 13.9 16.1 2.4 2 0 0 2 2 2 0 TonB polyproline region Trypan_PARP PF05887.11 EPA04664.1 - 1.8 8.5 27.2 0.19 11.7 17.2 2.9 2 1 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF3040 PF11239.8 EPA04665.1 - 0.12 12.7 0.3 0.45 10.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) DUF2371 PF10177.9 EPA04665.1 - 0.53 10.5 2.4 0.5 10.5 0.3 1.9 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) YtpI PF14007.6 EPA04665.1 - 1.3 9.2 7.6 0.2 11.8 1.4 2.2 2 0 0 2 2 2 0 YtpI-like protein tRNA_anti-codon PF01336.25 EPA04666.1 - 6.1e-06 26.1 0.3 7.8e-06 25.8 0.3 1.2 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain REPA_OB_2 PF16900.5 EPA04666.1 - 6.4e-05 22.8 0.8 7.2e-05 22.6 0.8 1.1 1 0 0 1 1 1 1 Replication protein A OB domain HupF_HypC PF01455.18 EPA04666.1 - 0.032 14.4 0.7 4.3 7.6 0.4 2.1 1 1 1 2 2 2 0 HupF/HypC family CBS PF00571.28 EPA04667.1 - 5.4e-48 161.3 15.4 1.2e-12 48.1 0.4 4.1 4 0 0 4 4 4 4 CBS domain Peptidase_S55 PF05580.12 EPA04667.1 - 0.015 15.3 0.8 0.024 14.6 0.3 1.8 1 1 0 1 1 1 0 SpoIVB peptidase S55 EMC1_C PF07774.13 EPA04667.1 - 0.041 13.5 2.6 0.075 12.7 2.4 1.6 1 1 0 1 1 1 0 ER membrane protein complex subunit 1, C-terminal PduV-EutP PF10662.9 EPA04667.1 - 0.042 13.6 9.5 2.3 7.9 0.6 3.8 2 1 1 4 4 4 0 Ethanolamine utilisation - propanediol utilisation Phytoreo_Pns PF05451.11 EPA04667.1 - 0.054 12.6 1.6 0.1 11.7 1.1 1.7 2 1 0 2 2 2 0 Phytoreovirus nonstructural protein Pns10/11 DUF3641 PF12345.8 EPA04667.1 - 0.1 12.7 0.0 3.4 7.7 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3641) SPAN PF02510.14 EPA04667.1 - 0.24 10.5 1.0 0.31 10.2 1.0 1.3 1 0 0 1 1 1 0 Surface presentation of antigens protein MgtC PF02308.16 EPA04668.1 - 4.7e-38 130.3 12.2 5.6e-38 130.0 12.2 1.0 1 0 0 1 1 1 1 MgtC family DUF4956 PF16316.5 EPA04668.1 - 0.1 12.3 0.6 0.11 12.1 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4956) PCMT PF01135.19 EPA04670.1 - 6.8e-58 195.9 0.0 8.5e-58 195.6 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 EPA04670.1 - 2e-08 34.1 0.0 3.4e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 EPA04670.1 - 5.5e-08 32.7 0.0 8.6e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 EPA04670.1 - 2.5e-07 30.0 0.0 3.8e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EPA04670.1 - 3.1e-06 27.8 0.0 5.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA04670.1 - 8.6e-05 23.1 0.0 0.00014 22.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 EPA04670.1 - 0.00033 20.4 0.0 0.00049 19.8 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit DOT1 PF08123.13 EPA04670.1 - 0.0017 18.0 0.0 0.003 17.1 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 CMAS PF02353.20 EPA04670.1 - 0.0029 16.9 0.0 0.0042 16.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase GidB PF02527.15 EPA04670.1 - 0.0056 16.0 0.1 0.011 15.0 0.0 1.5 2 0 0 2 2 2 1 rRNA small subunit methyltransferase G MTS PF05175.14 EPA04670.1 - 0.0074 15.8 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Lambda_CIII PF02061.16 EPA04670.1 - 0.0094 16.0 0.0 7.3 6.7 0.0 3.0 3 0 0 3 3 3 1 Lambda Phage CIII Methyltransf_4 PF02390.17 EPA04670.1 - 0.019 14.4 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Fibrillarin PF01269.17 EPA04670.1 - 0.029 13.5 0.0 0.047 12.8 0.0 1.3 1 0 0 1 1 1 0 Fibrillarin Ubie_methyltran PF01209.18 EPA04670.1 - 0.049 13.0 0.0 0.058 12.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EPA04670.1 - 0.064 13.2 0.0 0.09 12.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 EPA04670.1 - 0.08 12.9 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EPA04670.1 - 0.088 12.6 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.12 EPA04670.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) zf-C3HC4 PF00097.25 EPA04671.1 - 0.011 15.6 3.2 0.014 15.2 3.2 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FlpD PF02662.16 EPA04672.1 - 0.008 16.2 1.4 0.012 15.7 0.8 1.5 1 1 1 2 2 2 1 Methyl-viologen-reducing hydrogenase, delta subunit Syntaxin_2 PF14523.6 EPA04672.1 - 0.018 15.4 2.1 0.02 15.3 2.1 1.1 1 0 0 1 1 1 0 Syntaxin-like protein LZ_Tnp_IS66 PF13007.7 EPA04672.1 - 0.078 13.8 0.1 0.099 13.4 0.1 1.2 1 0 0 1 1 1 0 Transposase C of IS166 homeodomain LacI PF00356.21 EPA04672.1 - 0.53 10.1 4.0 9.3 6.1 0.3 2.8 2 1 0 2 2 2 0 Bacterial regulatory proteins, lacI family Radical_SAM PF04055.21 EPA04673.1 - 1.1e-09 38.9 2.0 1.4e-09 38.5 0.2 2.0 3 0 0 3 3 3 1 Radical SAM superfamily HPIP_like PF18524.1 EPA04673.1 - 6.3 6.7 11.2 0.14 11.9 0.9 2.8 3 0 0 3 3 3 0 High potential iron-sulfur protein like Cpn60_TCP1 PF00118.24 EPA04674.1 - 1e-175 585.1 18.0 1.2e-175 584.9 18.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3924 PF13062.6 EPA04674.1 - 0.0054 16.7 0.0 0.034 14.1 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3924) AdoMet_Synthase PF01941.19 EPA04675.1 - 2e-145 484.6 2.2 2.3e-145 484.4 2.2 1.0 1 0 0 1 1 1 1 S-adenosylmethionine synthetase (AdoMet synthetase) DUF4370 PF14290.6 EPA04675.1 - 0.086 12.7 0.3 7.5 6.3 0.6 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4370) S-AdoMet_synt_N PF00438.20 EPA04675.1 - 0.15 12.7 0.2 1.2 9.8 0.0 2.5 2 0 0 2 2 2 0 S-adenosylmethionine synthetase, N-terminal domain Zn-ribbon_8 PF09723.10 EPA04676.1 - 0.00071 19.6 0.4 0.00088 19.3 0.4 1.2 1 0 0 1 1 1 1 Zinc ribbon domain HypA PF01155.19 EPA04676.1 - 0.0052 16.8 0.2 0.0053 16.8 0.2 1.0 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rtf2 PF04641.12 EPA04676.1 - 0.009 15.4 0.3 0.0092 15.4 0.3 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger TF_Zn_Ribbon PF08271.12 EPA04676.1 - 0.016 14.7 1.0 2.2 7.8 0.1 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding zf-C2H2_4 PF13894.6 EPA04676.1 - 0.017 15.9 0.6 1.9 9.5 0.0 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HC5 PF06221.13 EPA04676.1 - 0.018 15.0 1.1 0.019 15.0 1.1 1.1 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type DUF2072 PF09845.9 EPA04676.1 - 0.023 15.0 0.1 0.023 14.9 0.1 1.0 1 0 0 1 1 1 0 Zn-ribbon containing protein DnaJ_CXXCXGXG PF00684.19 EPA04676.1 - 0.04 14.3 0.2 0.045 14.1 0.2 1.1 1 0 0 1 1 1 0 DnaJ central domain AAA_33 PF13671.6 EPA04679.1 - 2.1e-10 40.9 0.0 2.8e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EPA04679.1 - 0.0022 17.5 0.5 0.0023 17.5 0.5 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 DPBB_1 PF03330.18 EPA04679.1 - 0.05 13.9 0.0 0.07 13.4 0.0 1.3 1 0 0 1 1 1 0 Lytic transglycolase SHOCT PF09851.9 EPA04680.1 - 3e-11 42.7 2.1 5.5e-11 41.8 2.1 1.5 1 0 0 1 1 1 1 Short C-terminal domain Popeye PF04831.13 EPA04680.1 - 0.041 14.0 0.0 0.05 13.8 0.0 1.1 1 0 0 1 1 1 0 Popeye protein conserved region VbhA PF18495.1 EPA04680.1 - 0.1 12.4 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Antitoxin VbhA GvpG PF05120.12 EPA04680.1 - 0.11 12.6 0.6 0.17 11.9 0.6 1.5 1 1 0 1 1 1 0 Gas vesicle protein G DUF1707 PF08044.11 EPA04680.1 - 0.15 12.2 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1707) Sod_Fe_C PF02777.18 EPA04681.1 - 4.4e-36 123.1 1.5 7.7e-36 122.4 1.5 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EPA04681.1 - 1e-25 90.0 0.1 2.3e-25 88.9 0.1 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain BPD_transp_1 PF00528.22 EPA04682.1 - 5.7e-27 94.6 9.1 5.7e-27 94.6 9.1 2.3 3 0 0 3 3 3 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 EPA04682.1 - 0.052 13.5 0.2 0.052 13.5 0.2 2.7 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C TBP PF00352.21 EPA04683.1 - 9.3e-55 182.5 0.1 4.4e-27 93.9 0.0 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EPA04683.1 - 6.1e-07 29.5 0.0 0.02 15.0 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) SNF2_N PF00176.23 EPA04684.1 - 4.1e-38 131.0 0.0 5.9e-38 130.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EPA04684.1 - 4e-13 49.7 0.6 2.1e-12 47.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EPA04684.1 - 4.5e-09 36.6 0.1 4.5e-09 36.6 0.1 1.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EPA04684.1 - 3.6e-06 26.9 0.3 1.1e-05 25.3 0.0 1.9 2 1 1 3 3 3 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EPA04684.1 - 0.039 13.1 0.1 0.08 12.1 0.1 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase DUF5400 PF17379.2 EPA04685.1 - 0.035 14.6 0.6 0.077 13.5 0.6 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF5400) FlgD_ig PF13860.6 EPA04685.1 - 0.15 11.9 1.3 1.2 9.1 0.1 2.6 3 1 0 3 3 3 0 FlgD Ig-like domain BPD_transp_1 PF00528.22 EPA04686.1 - 6.8e-37 127.0 18.2 6.8e-37 127.0 18.2 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF5400 PF17379.2 EPA04686.1 - 0.0051 17.3 3.1 0.0053 17.2 0.2 2.5 2 0 0 2 2 2 1 Family of unknown function (DUF5400) DUF3481 PF11980.8 EPA04686.1 - 0.3 10.8 6.5 4.2 7.2 0.4 2.8 3 0 0 3 3 3 0 C-terminal domain of neuropilin glycoprotein FAD-oxidase_C PF02913.19 EPA04687.1 - 7.3e-42 143.7 0.0 1.1e-41 143.2 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EPA04687.1 - 1.3e-32 112.4 0.0 2.3e-32 111.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EPA04687.1 - 0.041 14.0 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 Berberine and berberine like MRP-S35 PF10246.9 EPA04687.1 - 0.12 12.3 0.1 0.33 10.9 0.1 1.7 1 1 0 1 1 1 0 Mitochondrial ribosomal protein MRP-S35 CRISPR_Cas2 PF09827.9 EPA04689.1 - 0.067 13.4 0.1 0.1 12.8 0.1 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas2 DEAD_2 PF06733.15 EPA04691.1 - 0.026 14.1 0.6 0.05 13.2 0.6 1.5 1 0 0 1 1 1 0 DEAD_2 RecG_N PF17190.4 EPA04691.1 - 0.13 13.0 2.2 0.2 12.4 2.2 1.5 1 0 0 1 1 1 0 RecG N-terminal helical domain AIDA PF16168.5 EPA04691.1 - 0.13 12.3 1.9 0.3 11.2 0.7 2.0 2 0 0 2 2 2 0 Adhesin of bacterial autotransporter system, probable stalk DUF5362 PF17319.2 EPA04691.1 - 0.17 11.7 2.2 3.3 7.6 0.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5362) HSP20 PF00011.21 EPA04692.1 - 2e-23 82.5 2.1 2.7e-23 82.0 2.1 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EPA04692.1 - 4.2e-06 26.2 0.0 6.2e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 EPA04692.1 - 0.00022 22.2 0.7 0.00035 21.5 0.7 1.3 1 0 0 1 1 1 1 CS domain FKBP26_C PF18046.1 EPA04692.1 - 0.00051 20.1 0.7 0.62 10.2 0.1 2.5 2 0 0 2 2 2 2 FKBP26_C-terminal PIH1_CS PF18201.1 EPA04692.1 - 0.015 15.7 0.1 0.021 15.2 0.1 1.4 1 0 0 1 1 1 0 PIH1 CS-like domain Lar_restr_allev PF14354.6 EPA04693.1 - 0.051 14.0 5.4 0.07 13.5 5.4 1.3 1 0 0 1 1 1 0 Restriction alleviation protein Lar Prim_Zn_Ribbon PF08273.12 EPA04693.1 - 0.083 13.2 4.8 0.11 12.8 1.3 2.2 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase HTH_5 PF01022.20 EPA04694.1 - 0.00063 19.6 1.6 0.0022 17.8 0.6 2.4 2 1 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_34 PF13601.6 EPA04694.1 - 0.014 15.5 0.2 0.039 14.1 0.2 1.7 1 0 0 1 1 1 0 Winged helix DNA-binding domain Baculo_LEF-11 PF06385.12 EPA04694.1 - 0.035 14.6 0.7 4 8.0 0.1 2.3 2 0 0 2 2 2 0 Baculovirus LEF-11 protein HTH_20 PF12840.7 EPA04694.1 - 0.054 13.6 0.0 0.47 10.6 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain MRP-L20 PF12824.7 EPA04694.1 - 0.14 12.3 0.9 0.21 11.7 0.9 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 DUF4709 PF15821.5 EPA04694.1 - 0.18 12.1 4.8 0.19 12.0 1.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4709) TrmB PF01978.19 EPA04694.1 - 0.2 11.6 1.3 1.1 9.2 0.1 2.6 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 EPA04694.1 - 3.4 7.7 6.3 0.45 10.5 0.4 2.6 4 0 0 4 4 4 0 HTH domain OsmC PF02566.19 EPA04695.1 - 2.7e-17 63.1 0.0 4.6e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 OsmC-like protein zf-NADH-PPase PF09297.11 EPA04696.1 - 0.00037 20.1 3.0 0.013 15.1 0.7 2.1 2 0 0 2 2 2 2 NADH pyrophosphatase zinc ribbon domain Peptidase_C74 PF12387.8 EPA04696.1 - 0.0057 16.2 1.2 0.0057 16.2 1.2 1.0 1 0 0 1 1 1 1 Pestivirus NS2 peptidase zinc-ribbons_6 PF07191.12 EPA04696.1 - 0.0085 16.0 0.1 0.0094 15.9 0.1 1.1 1 0 0 1 1 1 1 zinc-ribbons Prok-RING_4 PF14447.6 EPA04696.1 - 0.012 15.5 0.8 0.013 15.3 0.8 1.1 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_ribbon_recom PF13408.6 EPA04696.1 - 0.025 15.1 5.1 0.13 12.7 1.2 2.0 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain zf_UBZ PF18439.1 EPA04696.1 - 0.03 13.9 1.5 0.14 11.8 0.1 2.0 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger TF_Zn_Ribbon PF08271.12 EPA04696.1 - 0.031 13.8 2.1 0.27 10.8 0.1 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding Zn_ribbon_SprT PF17283.2 EPA04696.1 - 0.049 13.5 2.3 4.8 7.2 0.1 2.1 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 EPA04696.1 - 0.057 13.5 3.9 0.45 10.7 3.9 1.9 1 1 0 1 1 1 0 Zinc ribbon domain TFIIS_C PF01096.18 EPA04696.1 - 0.075 12.9 3.1 4.2 7.3 0.1 2.1 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-HIT PF04438.16 EPA04696.1 - 0.3 11.0 5.3 0.64 9.9 5.3 1.6 1 1 0 1 1 1 0 HIT zinc finger DUF3290 PF11694.8 EPA04697.1 - 0.11 12.5 0.1 0.13 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) ArsC PF03960.15 EPA04699.1 - 5e-13 48.9 0.2 6.1e-13 48.6 0.2 1.1 1 0 0 1 1 1 1 ArsC family Glutaredoxin PF00462.24 EPA04699.1 - 0.00057 20.1 1.9 0.071 13.3 0.3 2.1 1 1 1 2 2 2 2 Glutaredoxin PriCT_1 PF08708.11 EPA04699.1 - 0.03 14.1 0.0 0.044 13.5 0.0 1.2 1 0 0 1 1 1 0 Primase C terminal 1 (PriCT-1) CarboxypepD_reg PF13620.6 EPA04700.1 - 9.6e-08 32.2 1.1 1.6e-07 31.5 1.1 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Big_1 PF02369.16 EPA04700.1 - 1.2e-05 25.2 1.2 1.2e-05 25.2 1.2 1.9 1 1 1 2 2 2 1 Bacterial Ig-like domain (group 1) CarbopepD_reg_2 PF13715.6 EPA04700.1 - 0.00014 21.8 1.1 0.00022 21.2 1.1 1.4 1 0 0 1 1 1 1 CarboxypepD_reg-like domain MetallophosN PF16371.5 EPA04700.1 - 0.00015 21.9 0.6 0.00028 21.1 0.6 1.5 1 0 0 1 1 1 1 N terminal of Calcineurin-like phosphoesterase SdrD_B PF17210.3 EPA04700.1 - 0.0075 16.5 0.7 0.013 15.7 0.7 1.4 1 0 0 1 1 1 1 SdrD B-like domain Big_6 PF17936.1 EPA04700.1 - 0.038 14.3 0.5 0.07 13.4 0.5 1.4 1 0 0 1 1 1 0 Bacterial Ig domain GBS_Bsp-like PF08481.10 EPA04700.1 - 0.047 13.8 0.1 0.09 12.9 0.1 1.5 1 0 0 1 1 1 0 GBS Bsp-like repeat Complex1_49kDa PF00346.19 EPA04701.1 - 1.6e-29 102.8 0.0 1.3e-15 57.3 0.0 2.0 1 1 1 2 2 2 2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Ribosomal_S5_C PF03719.15 EPA04701.1 - 0.039 13.4 0.1 0.063 12.7 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein S5, C-terminal domain NADHdh PF00146.21 EPA04702.1 - 9.8e-26 90.7 4.4 9.8e-26 90.7 4.4 1.4 2 0 0 2 2 2 1 NADH dehydrogenase NDUF_B12 PF08122.12 EPA04702.1 - 0.12 12.4 0.3 0.12 12.4 0.3 2.3 2 1 1 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family Shikimate_dh_N PF08501.11 EPA04703.1 - 2.5e-28 98.1 0.0 3.7e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain DHquinase_I PF01487.15 EPA04704.1 - 1.6e-10 41.7 0.0 1.7e-10 41.6 0.0 1.0 1 0 0 1 1 1 1 Type I 3-dehydroquinase Met_10 PF02475.16 EPA04706.1 - 3.5e-47 160.7 0.1 3.9e-47 160.6 0.1 1.0 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.13 EPA04706.1 - 4.9e-05 22.9 0.2 9e-05 22.0 0.1 1.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EPA04706.1 - 0.0019 17.8 0.0 0.0024 17.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain ADH_zinc_N PF00107.26 EPA04706.1 - 0.025 14.6 0.1 0.14 12.2 0.0 2.1 2 1 1 3 3 3 0 Zinc-binding dehydrogenase DNA_methylase PF00145.17 EPA04706.1 - 0.037 13.4 0.0 0.061 12.6 0.0 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Methyltransf_15 PF09445.10 EPA04706.1 - 0.044 13.4 0.1 0.081 12.5 0.1 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_16 PF10294.9 EPA04706.1 - 0.044 13.5 0.0 0.061 13.1 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_25 PF13649.6 EPA04706.1 - 0.14 12.9 0.0 0.25 12.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain ABC_tran PF00005.27 EPA04707.1 - 3.2e-19 69.8 0.5 7.7e-19 68.6 0.5 1.6 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EPA04707.1 - 0.00056 19.8 0.5 0.25 11.1 0.0 2.8 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EPA04707.1 - 0.0018 17.7 1.7 0.0041 16.6 1.7 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Ribo_biogen_C PF04034.13 EPA04709.1 - 2.1e-37 127.7 0.0 2.9e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EPA04709.1 - 8.4e-07 28.7 0.1 1.3e-06 28.1 0.1 1.3 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Pam17 PF08566.10 EPA04711.1 - 0.042 13.7 0.3 0.056 13.3 0.3 1.1 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 Nitr_red_assoc PF09655.10 EPA04711.1 - 0.096 13.3 0.3 0.12 13.0 0.3 1.1 1 0 0 1 1 1 0 Conserved nitrate reductase-associated protein (Nitr_red_assoc) DUF3408 PF11888.8 EPA04711.1 - 0.16 12.1 6.7 0.055 13.6 2.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3408) AIRS_C PF02769.22 EPA04712.1 - 3.5e-25 89.0 0.0 7.1e-25 88.0 0.0 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 EPA04712.1 - 4.2e-16 59.4 1.3 7.4e-16 58.6 1.3 1.5 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain TBP PF00352.21 EPA04714.1 - 5.9e-55 183.2 0.0 2.2e-27 94.8 0.0 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EPA04714.1 - 6.3e-08 32.6 0.0 0.00046 20.2 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) RTT107_BRCT_5 PF16770.5 EPA04714.1 - 0.098 12.5 0.2 0.33 10.8 0.1 1.8 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain Na_H_Exchanger PF00999.21 EPA04715.1 - 7.6e-61 206.0 50.9 1e-60 205.6 50.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family tRNA_bind PF01588.20 EPA04716.1 - 2.9e-22 78.6 0.0 3.3e-22 78.4 0.0 1.0 1 0 0 1 1 1 1 Putative tRNA binding domain Adenine_glyco PF03352.13 EPA04717.1 - 1.7e-80 268.9 0.3 2.1e-80 268.6 0.3 1.0 1 0 0 1 1 1 1 Methyladenine glycosylase DUF3383 PF11863.8 EPA04717.1 - 0.11 11.5 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3383) DUF1129 PF06570.11 EPA04718.1 - 0.19 11.2 0.5 0.2 11.2 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Glycos_transf_2 PF00535.26 EPA04719.1 - 4.4e-27 95.0 0.0 6.1e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EPA04719.1 - 7.9e-21 75.0 0.0 1.1e-20 74.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EPA04719.1 - 1.6e-09 37.5 0.1 3.5e-09 36.4 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 EPA04719.1 - 5e-07 29.5 0.1 7.6e-07 28.9 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 EPA04719.1 - 0.00037 21.0 0.0 0.00066 20.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 DUF1512 PF07431.12 EPA04720.1 - 1e-131 439.2 7.1 1.2e-131 439.0 7.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1512) Linker_histone PF00538.19 EPA04720.1 - 0.38 11.2 3.8 1.5 9.3 0.1 2.8 3 0 0 3 3 3 0 linker histone H1 and H5 family Trypsin_2 PF13365.6 EPA04721.1 - 2.3e-33 116.2 0.3 4e-33 115.4 0.3 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EPA04721.1 - 1.1e-14 54.8 0.5 5.8e-14 52.4 0.1 2.2 2 1 0 2 2 2 1 Trypsin PDZ_2 PF13180.6 EPA04721.1 - 1.5e-13 50.8 4.0 2.9e-13 50.0 0.6 2.7 2 1 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 EPA04721.1 - 2.6e-06 27.2 2.0 0.015 15.1 0.3 3.3 3 0 0 3 3 3 2 PDZ domain Peptidase_S29 PF02907.15 EPA04721.1 - 0.0034 17.1 0.1 0.0061 16.3 0.1 1.4 1 0 0 1 1 1 1 Hepatitis C virus NS3 protease Peptidase_S7 PF00949.21 EPA04721.1 - 0.01 15.7 2.8 0.027 14.3 0.5 2.4 2 0 0 2 2 2 0 Peptidase S7, Flavivirus NS3 serine protease PDZ PF00595.24 EPA04721.1 - 0.01 16.2 2.4 2.6 8.4 0.5 3.3 3 0 0 3 3 3 0 PDZ domain Peptidase_S46 PF10459.9 EPA04721.1 - 0.014 14.1 1.1 0.02 13.6 0.3 1.5 2 0 0 2 2 2 0 Peptidase S46 Peptidase_S32 PF05579.13 EPA04721.1 - 0.035 13.3 2.5 2.7 7.1 0.4 2.3 1 1 1 2 2 2 0 Equine arteritis virus serine endopeptidase S32 DUF3990 PF13151.6 EPA04722.1 - 0.068 12.9 0.0 0.086 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) DLH PF01738.18 EPA04723.1 - 2.3e-51 174.4 0.0 3.1e-51 174.0 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Chlorophyllase PF07224.11 EPA04723.1 - 5.6e-06 25.6 0.0 8.3e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase Peptidase_S9 PF00326.21 EPA04723.1 - 9.5e-06 25.2 0.0 0.044 13.3 0.1 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family BAAT_C PF08840.11 EPA04723.1 - 3.2e-05 23.9 0.2 0.0019 18.1 0.0 2.4 1 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_1 PF00561.20 EPA04723.1 - 6.5e-05 22.7 0.1 9.1e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EPA04723.1 - 0.00014 20.9 0.0 0.0002 20.4 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 EPA04723.1 - 0.00065 19.0 0.0 0.0036 16.6 0.0 1.8 1 1 1 2 2 2 1 Serine aminopeptidase, S33 PAF-AH_p_II PF03403.13 EPA04723.1 - 0.021 13.4 0.0 0.12 10.9 0.0 1.8 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II IMPa_helical PF18642.1 EPA04724.1 - 0.041 14.3 0.2 0.057 13.8 0.2 1.3 1 0 0 1 1 1 0 Immunomodulating metalloprotease helical domain tRNA-synt_1f PF01921.18 EPA04725.1 - 3.2e-109 365.2 0.0 1e-108 363.5 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (K) PolyA_pol_RNAbd PF12627.7 EPA04725.1 - 0.0074 16.0 0.0 0.02 14.6 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA-synt_1g PF09334.11 EPA04725.1 - 0.067 11.9 0.2 0.33 9.6 0.0 2.0 1 1 0 2 2 2 0 tRNA synthetases class I (M) Radical_SAM PF04055.21 EPA04726.1 - 6.8e-21 75.4 0.2 1.1e-20 74.7 0.2 1.3 1 0 0 1 1 1 1 Radical SAM superfamily AP_endonuc_2 PF01261.24 EPA04726.1 - 0.02 14.3 0.0 0.21 11.0 0.0 2.2 1 1 1 2 2 2 0 Xylose isomerase-like TIM barrel PEP_hydrolase PF09370.10 EPA04726.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate hydrolase-like Fer4_14 PF13394.6 EPA04726.1 - 0.2 11.8 1.1 0.38 10.9 0.1 2.0 3 0 0 3 3 3 0 4Fe-4S single cluster domain AhpC-TSA PF00578.21 EPA04728.1 - 4.1e-39 133.3 0.2 4.8e-39 133.1 0.2 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EPA04728.1 - 9.5e-27 93.5 0.1 1.1e-26 93.3 0.1 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 EPA04728.1 - 4.5e-08 33.2 0.1 8.1e-08 32.4 0.1 1.4 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF899 PF05988.12 EPA04728.1 - 9.5e-08 31.8 0.0 1.1e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) SCO1-SenC PF02630.14 EPA04728.1 - 0.0013 18.7 0.1 0.0027 17.6 0.1 1.6 1 1 0 1 1 1 1 SCO1/SenC GSHPx PF00255.19 EPA04728.1 - 0.039 13.5 0.1 0.078 12.6 0.0 1.6 1 1 1 2 2 2 0 Glutathione peroxidase DUF443 PF04276.12 EPA04729.1 - 0.051 13.4 8.0 0.94 9.2 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF443) UMPH-1 PF05822.12 EPA04729.1 - 0.073 12.6 0.5 6.6 6.2 0.0 2.1 1 1 1 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) Tox-WTIP PF15654.6 EPA04729.1 - 0.24 11.8 1.5 1.9 8.9 0.0 2.2 1 1 1 2 2 2 0 Toxin with a conserved tryptophan and TIP tripeptide motif DUF3021 PF11457.8 EPA04729.1 - 2.7 8.3 13.1 0.14 12.5 3.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3021) MscS_porin PF12795.7 EPA04730.1 - 2e-06 27.5 11.8 2e-06 27.5 11.8 3.1 2 1 0 3 3 3 1 Mechanosensitive ion channel porin domain EzrA PF06160.12 EPA04730.1 - 0.0031 15.8 18.8 0.0031 15.8 18.8 3.0 1 1 1 3 3 3 2 Septation ring formation regulator, EzrA GBR2_CC PF18455.1 EPA04730.1 - 0.029 14.5 0.2 0.1 12.7 0.2 2.0 1 0 0 1 1 1 0 Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain APG6_N PF17675.1 EPA04730.1 - 0.063 13.8 49.9 0.065 13.8 14.5 3.2 1 1 1 3 3 3 0 Apg6 coiled-coil region WEMBL PF05701.11 EPA04730.1 - 0.11 11.2 41.1 0.17 10.6 25.7 2.1 1 1 1 2 2 2 0 Weak chloroplast movement under blue light HMMR_N PF15905.5 EPA04730.1 - 0.16 11.5 53.1 0.49 9.8 37.4 2.1 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF3584 PF12128.8 EPA04730.1 - 0.17 9.4 37.9 0.19 9.2 37.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) IFT57 PF10498.9 EPA04730.1 - 0.19 10.7 40.3 0.2 10.6 8.1 3.2 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 Fez1 PF06818.15 EPA04730.1 - 0.35 11.3 40.0 1.3e+03 -0.4 40.0 2.6 1 1 0 1 1 1 0 Fez1 Mce4_CUP1 PF11887.8 EPA04730.1 - 0.51 9.8 4.1 0.73 9.2 0.7 2.1 1 1 1 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative TRPM_tetra PF16519.5 EPA04730.1 - 0.59 10.3 14.4 1.1 9.4 1.2 3.8 2 1 1 3 3 3 0 Tetramerisation domain of TRPM HIP1_clath_bdg PF16515.5 EPA04730.1 - 1.2 9.7 41.0 0.53 10.9 5.2 3.9 2 1 2 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FlaC_arch PF05377.11 EPA04730.1 - 1.7 9.1 39.2 0.21 12.0 2.5 5.4 2 2 4 6 6 6 0 Flagella accessory protein C (FlaC) Laminin_II PF06009.12 EPA04730.1 - 2.2 8.3 34.6 0.82 9.7 12.8 3.2 1 1 1 3 3 3 0 Laminin Domain II Prp19 PF08606.11 EPA04730.1 - 3.7 7.6 9.0 0.8 9.7 0.1 3.7 3 2 1 4 4 4 0 Prp19/Pso4-like DUF4201 PF13870.6 EPA04730.1 - 3.8 7.2 43.2 0.9 9.2 2.6 3.8 2 1 2 4 4 4 0 Domain of unknown function (DUF4201) Spc7 PF08317.11 EPA04730.1 - 4.1 6.2 47.8 0.32 9.8 14.2 3.0 1 1 2 3 3 2 0 Spc7 kinetochore protein Streptin-Immun PF11083.8 EPA04730.1 - 4.9 7.6 30.6 0.47 10.9 2.1 4.4 2 1 1 3 3 3 0 Lantibiotic streptin immunity protein DUF1664 PF07889.12 EPA04730.1 - 5.1 7.1 29.9 11 6.1 2.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 EPA04730.1 - 6.3 6.9 47.9 0.55 10.3 11.5 3.4 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein FH2 PF02181.23 EPA04730.1 - 7.9 5.5 32.5 0.1 11.7 3.3 3.1 1 1 2 3 3 3 0 Formin Homology 2 Domain DUF948 PF06103.11 EPA04730.1 - 8.9 6.6 18.5 0.18 12.1 1.6 3.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Uso1_p115_C PF04871.13 EPA04730.1 - 9.9 6.6 50.4 0.88 9.9 13.7 3.1 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Zn-ribbon_8 PF09723.10 EPA04731.1 - 0.0036 17.4 0.8 0.0046 17.0 0.8 1.3 1 0 0 1 1 1 1 Zinc ribbon domain OrfB_Zn_ribbon PF07282.11 EPA04731.1 - 0.041 13.8 0.7 0.062 13.2 0.7 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-ACC PF17848.1 EPA04731.1 - 1.3 9.1 7.1 1.1 9.4 0.5 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain DUF4364 PF14277.6 EPA04732.1 - 0.0046 16.7 0.1 0.009 15.8 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4364) HTH_45 PF14947.6 EPA04732.1 - 0.028 14.4 0.1 0.056 13.4 0.1 1.7 1 1 0 1 1 1 0 Winged helix-turn-helix Radical_SAM PF04055.21 EPA04733.1 - 8.3e-12 45.8 0.1 2e-11 44.5 0.0 1.7 2 0 0 2 2 2 1 Radical SAM superfamily BATS PF06968.13 EPA04733.1 - 0.013 15.6 0.0 0.031 14.4 0.0 1.6 1 0 0 1 1 1 0 Biotin and Thiamin Synthesis associated domain SpoU_sub_bind PF08032.12 EPA04733.1 - 0.055 13.7 0.4 21 5.5 0.0 3.9 3 1 2 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding CdvA PF18822.1 EPA04733.1 - 0.45 10.4 0.1 0.45 10.4 0.1 3.5 5 0 0 5 5 5 0 CdvA-like coiled-coil domain Radical_SAM_C PF16199.5 EPA04734.1 - 2.4e-26 91.6 0.2 6.3e-26 90.2 0.2 1.8 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EPA04734.1 - 1.9e-20 73.9 0.1 7.1e-20 72.0 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_10 PF13673.7 EPA04734.1 - 6.4e-06 26.1 0.0 2.1e-05 24.5 0.1 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EPA04734.1 - 5.7e-05 23.3 0.0 0.00013 22.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family SapB_1 PF05184.15 EPA04734.1 - 1.2 9.2 3.7 1.4 9.0 1.7 2.2 2 0 0 2 2 2 0 Saposin-like type B, region 1 MIP PF00230.20 EPA04735.1 - 6.1e-54 183.1 18.8 7.2e-54 182.9 18.8 1.0 1 0 0 1 1 1 1 Major intrinsic protein Ldr_toxin PF13940.6 EPA04735.1 - 0.0012 18.8 1.5 0.0042 17.1 1.5 2.0 1 0 0 1 1 1 1 Toxin Ldr, type I toxin-antitoxin system Peptidase_M24 PF00557.24 EPA04736.1 - 7.9e-33 113.9 1.2 1.5e-32 113.0 1.2 1.5 1 1 0 1 1 1 1 Metallopeptidase family M24 HSR PF03172.13 EPA04736.1 - 0.006 16.7 0.3 0.61 10.3 0.1 2.3 2 0 0 2 2 2 1 HSR domain ApbE PF02424.15 EPA04736.1 - 0.012 15.2 0.1 0.017 14.7 0.1 1.2 1 0 0 1 1 1 0 ApbE family ATP-cone PF03477.16 EPA04736.1 - 0.55 10.9 5.2 19 5.9 0.1 3.2 3 1 0 3 3 3 0 ATP cone domain PAC2 PF09754.9 EPA04738.1 - 6.5e-44 150.5 0.0 7.4e-44 150.3 0.0 1.0 1 0 0 1 1 1 1 PAC2 family Ferritin PF00210.24 EPA04739.1 - 8.6e-41 139.2 0.7 1e-40 139.0 0.7 1.0 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 EPA04739.1 - 7e-05 23.3 0.9 0.0001 22.7 0.9 1.3 1 0 0 1 1 1 1 Rubrerythrin Lipoprotein_10 PF03202.13 EPA04739.1 - 0.043 14.3 2.0 0.091 13.2 0.5 2.0 2 1 0 2 2 2 0 Putative mycoplasma lipoprotein, C-terminal region Nuc_rec_co-act PF08815.10 EPA04739.1 - 0.2 11.5 0.2 1.1 9.2 0.0 2.1 2 0 0 2 2 2 0 Nuclear receptor coactivator NPV_P10 PF05531.12 EPA04740.1 - 0.00064 20.1 0.8 0.00078 19.9 0.8 1.1 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein SKA2 PF16740.5 EPA04740.1 - 0.00078 19.2 4.5 0.2 11.4 0.3 2.0 1 1 1 2 2 2 2 Spindle and kinetochore-associated protein 2 JIP_LZII PF16471.5 EPA04740.1 - 0.005 17.0 7.2 0.0079 16.3 7.2 1.4 1 1 0 1 1 1 1 JNK-interacting protein leucine zipper II TMF_TATA_bd PF12325.8 EPA04740.1 - 0.0053 17.0 6.8 0.0065 16.7 6.8 1.2 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding JAKMIP_CC3 PF16034.5 EPA04740.1 - 0.0064 16.5 4.1 0.0076 16.2 4.1 1.0 1 0 0 1 1 1 1 JAKMIP CC3 domain Dynamitin PF04912.14 EPA04740.1 - 0.013 14.9 6.2 0.014 14.8 6.2 1.0 1 0 0 1 1 1 0 Dynamitin ZapB PF06005.12 EPA04740.1 - 0.015 15.7 9.4 0.062 13.8 9.4 1.8 1 1 0 1 1 1 0 Cell division protein ZapB Spc7 PF08317.11 EPA04740.1 - 0.019 13.9 9.6 0.024 13.5 9.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF948 PF06103.11 EPA04740.1 - 0.019 15.2 1.3 0.041 14.1 0.7 1.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 EPA04740.1 - 0.034 14.5 7.3 0.085 13.2 7.3 1.6 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FadA PF09403.10 EPA04740.1 - 0.038 14.5 11.3 0.051 14.1 11.0 1.4 1 1 0 1 1 1 0 Adhesion protein FadA Dynactin_p22 PF07426.11 EPA04740.1 - 0.045 13.6 8.4 0.61 9.9 1.9 2.0 1 1 1 2 2 2 0 Dynactin subunit p22 TipAS PF07739.13 EPA04740.1 - 0.055 14.0 4.2 0.12 13.0 3.5 1.7 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain CLZ PF16526.5 EPA04740.1 - 0.074 13.4 4.9 1.3 9.4 2.0 2.0 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ABC_tran_CTD PF16326.5 EPA04740.1 - 0.076 13.3 10.0 1.1 9.6 3.0 2.0 1 1 0 1 1 1 0 ABC transporter C-terminal domain Seryl_tRNA_N PF02403.22 EPA04740.1 - 0.088 13.0 8.0 0.15 12.3 8.0 1.4 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain MtrG PF04210.13 EPA04740.1 - 0.089 12.7 3.2 0.27 11.1 3.2 1.9 1 1 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G PaaX_C PF08223.11 EPA04740.1 - 0.09 13.1 3.0 2.5 8.5 0.5 2.0 1 1 1 2 2 2 0 PaaX-like protein C-terminal domain Dor1 PF04124.12 EPA04740.1 - 0.093 11.4 4.5 0.11 11.2 4.5 1.1 1 0 0 1 1 1 0 Dor1-like family Bap31_Bap29_C PF18035.1 EPA04740.1 - 0.096 12.7 12.2 0.38 10.8 4.8 2.2 1 1 1 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF5344 PF17279.2 EPA04740.1 - 0.1 13.2 8.0 1.1 9.9 1.4 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5344) DUF883 PF05957.13 EPA04740.1 - 0.12 13.0 2.6 0.15 12.7 2.6 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DUF4446 PF14584.6 EPA04740.1 - 0.13 12.2 7.2 0.14 12.1 7.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF3450 PF11932.8 EPA04740.1 - 0.18 11.1 5.3 0.21 10.8 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) OmpH PF03938.14 EPA04740.1 - 0.2 12.0 7.8 0.22 11.8 7.8 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DASH_Dad3 PF08656.10 EPA04740.1 - 0.23 11.6 4.7 0.61 10.2 4.7 1.7 1 1 0 1 1 1 0 DASH complex subunit Dad3 DUF3958 PF13125.6 EPA04740.1 - 0.26 11.5 11.6 1.7 8.9 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3958) Syntaxin_2 PF14523.6 EPA04740.1 - 0.38 11.1 7.5 3.5 8.1 0.4 2.1 1 1 1 2 2 2 0 Syntaxin-like protein HemX PF04375.14 EPA04740.1 - 0.38 10.0 5.0 0.43 9.8 5.0 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DivIC PF04977.15 EPA04740.1 - 0.82 9.5 8.8 3.1 7.6 1.2 2.0 1 1 1 2 2 2 0 Septum formation initiator EMC3_TMCO1 PF01956.16 EPA04740.1 - 1.3 8.7 6.8 1.5 8.6 6.8 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Uteroglobin PF01099.17 EPA04740.1 - 1.4 9.3 4.7 1.7 9.0 4.7 1.2 1 0 0 1 1 1 0 Uteroglobin family CotJB PF12652.7 EPA04740.1 - 1.5 9.0 7.6 3 8.1 2.2 2.1 1 1 1 2 2 2 0 CotJB protein Atg14 PF10186.9 EPA04740.1 - 1.8 7.5 7.6 2.1 7.3 7.6 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tho2 PF11262.8 EPA04740.1 - 2 7.5 10.3 2.2 7.4 10.3 1.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF1640 PF07798.11 EPA04740.1 - 2.1 8.4 9.7 2.7 8.0 9.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF1910 PF08928.10 EPA04740.1 - 2.5 8.1 8.9 0.99 9.4 2.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1910) LMBR1 PF04791.16 EPA04740.1 - 3.6 6.4 4.1 4.1 6.2 4.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein YtxH PF12732.7 EPA04740.1 - 3.7 8.2 6.2 7.7 7.1 6.2 1.6 1 1 0 1 1 1 0 YtxH-like protein DUF2951 PF11166.8 EPA04740.1 - 4.9 7.4 10.0 5.7 7.2 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) TMPIT PF07851.13 EPA04740.1 - 5.6 6.1 7.9 6.3 5.9 7.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein Polyketide_cyc2 PF10604.9 EPA04741.1 - 5.6e-10 39.6 0.0 6e-10 39.5 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 EPA04741.1 - 2.4e-05 24.6 0.0 3e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AHSA1 PF08327.11 EPA04741.1 - 0.066 13.5 0.1 0.077 13.2 0.1 1.2 1 0 0 1 1 1 0 Activator of Hsp90 ATPase homolog 1-like protein DUF538 PF04398.12 EPA04742.1 - 0.055 13.9 0.1 0.07 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF538 DUF4197 PF13852.6 EPA04743.1 - 0.034 13.8 0.0 0.036 13.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4197) Methyltransf_31 PF13847.6 EPA04744.1 - 3.5e-09 36.6 0.1 4.4e-09 36.3 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EPA04744.1 - 9.2e-08 31.8 0.1 1e-07 31.7 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EPA04744.1 - 1.7e-06 28.7 0.0 2.4e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EPA04744.1 - 3.7e-06 26.6 0.0 4.5e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EPA04744.1 - 3.4e-05 23.3 0.0 3.9e-05 23.1 0.0 1.0 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EPA04744.1 - 0.00035 21.2 0.1 0.0005 20.8 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EPA04744.1 - 0.00043 20.2 0.1 0.00053 19.9 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EPA04744.1 - 0.002 17.7 0.0 0.0022 17.6 0.0 1.1 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_11 PF08241.12 EPA04744.1 - 0.0023 18.5 0.0 0.0037 17.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EPA04744.1 - 0.004 16.9 0.0 0.004 16.9 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.18 EPA04744.1 - 0.0044 16.7 0.1 0.0061 16.3 0.1 1.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Ubie_methyltran PF01209.18 EPA04744.1 - 0.0077 15.6 0.0 0.0088 15.4 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Cons_hypoth95 PF03602.15 EPA04744.1 - 0.0086 15.7 0.0 0.0091 15.7 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_4 PF02390.17 EPA04744.1 - 0.01 15.3 0.1 0.015 14.8 0.1 1.3 1 0 0 1 1 1 1 Putative methyltransferase GCD14 PF08704.10 EPA04744.1 - 0.013 15.2 0.0 0.014 15.1 0.0 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_3 PF01596.17 EPA04744.1 - 0.014 14.5 0.0 0.015 14.5 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_23 PF13489.6 EPA04744.1 - 0.015 15.2 0.0 0.015 15.2 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 EPA04744.1 - 0.016 15.0 0.0 0.017 14.9 0.0 1.1 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_32 PF13679.6 EPA04744.1 - 0.019 14.9 0.0 0.02 14.9 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 EPA04744.1 - 0.031 13.7 0.0 0.036 13.5 0.0 1.0 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_15 PF09445.10 EPA04744.1 - 0.075 12.6 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase AviRa PF11599.8 EPA04744.1 - 0.083 12.3 0.0 0.089 12.2 0.0 1.1 1 0 0 1 1 1 0 RRNA methyltransferase AviRa FtsJ PF01728.19 EPA04744.1 - 0.14 12.3 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 FtsJ-like methyltransferase N6_N4_Mtase PF01555.18 EPA04744.1 - 0.16 11.7 0.1 0.18 11.5 0.1 1.1 1 0 0 1 1 1 0 DNA methylase Mut7-C PF01927.16 EPA04745.1 - 4.3e-26 91.8 0.1 5.1e-26 91.5 0.1 1.0 1 0 0 1 1 1 1 Mut7-C RNAse domain DUF5615 PF18480.1 EPA04745.1 - 1.9e-05 24.3 0.1 3.1e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5615) PIN_10 PF18478.1 EPA04745.1 - 0.002 18.3 0.1 0.0047 17.1 0.1 1.7 1 1 0 1 1 1 1 PIN like domain Cas6 PF09559.10 EPA04745.1 - 0.0073 16.3 0.3 0.0087 16.0 0.3 1.1 1 0 0 1 1 1 1 Cas6 Crispr RNA_pol_Rpb2_4 PF04566.13 EPA04745.1 - 0.01 16.1 2.9 0.024 14.9 2.8 1.8 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 4 DUF5379 PF17350.2 EPA04746.1 - 0.0003 21.0 3.7 0.00045 20.4 3.7 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5379) 7TM_GPCR_Srsx PF10320.9 EPA04746.1 - 0.0039 16.6 4.6 0.0055 16.1 4.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx RSN1_TM PF13967.6 EPA04746.1 - 0.0055 16.5 0.4 0.058 13.2 0.0 2.1 1 1 1 2 2 2 1 Late exocytosis, associated with Golgi transport DUF543 PF04418.12 EPA04746.1 - 0.05 13.6 0.0 0.087 12.8 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF543) Multi_Drug_Res PF00893.19 EPA04746.1 - 0.056 14.1 3.7 0.081 13.6 3.7 1.3 1 0 0 1 1 1 0 Small Multidrug Resistance protein Colicin_V PF02674.16 EPA04746.1 - 0.11 12.5 4.2 0.11 12.5 3.0 1.5 1 1 1 2 2 2 0 Colicin V production protein DUF202 PF02656.15 EPA04746.1 - 0.21 12.0 5.1 0.62 10.6 5.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DUF21 PF01595.20 EPA04746.1 - 0.28 10.9 3.8 0.72 9.5 3.8 1.7 1 1 0 1 1 1 0 Cyclin M transmembrane N-terminal domain Rab5ip PF07019.12 EPA04746.1 - 0.31 11.6 5.4 0.66 10.6 5.4 1.6 1 1 0 1 1 1 0 Rab5-interacting protein (Rab5ip) TrmK PF04816.12 EPA04747.1 - 0.021 14.4 0.9 0.024 14.2 0.9 1.1 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase Methyltransf_18 PF12847.7 EPA04747.1 - 0.064 13.2 0.8 0.072 13.0 0.8 1.1 1 0 0 1 1 1 0 Methyltransferase domain FbpA PF05833.11 EPA04748.1 - 6.9e-37 127.3 7.5 9.1e-37 126.9 7.5 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 EPA04748.1 - 2.8e-21 76.2 0.0 1.3e-20 74.1 0.0 2.2 2 0 0 2 2 2 1 NFACT protein RNA binding domain PKcGMP_CC PF16808.5 EPA04748.1 - 0.021 14.6 3.4 0.064 13.1 3.4 1.8 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Tweety PF04906.13 EPA04748.1 - 2.1 6.9 6.8 4.5 5.8 1.5 2.2 1 1 1 2 2 2 0 Tweety FlaC_arch PF05377.11 EPA04748.1 - 4.3 7.8 6.7 2.3 8.7 2.7 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) zf-met PF12874.7 EPA04749.1 - 0.028 14.8 0.8 0.035 14.5 0.8 1.2 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-like PF04071.12 EPA04749.1 - 0.078 12.9 0.2 0.078 12.9 0.2 1.1 1 0 0 1 1 1 0 Cysteine-rich small domain zf-met PF12874.7 EPA04752.1 - 0.034 14.5 0.8 0.043 14.2 0.8 1.2 1 0 0 1 1 1 0 Zinc-finger of C2H2 type TAL_FSA PF00923.19 EPA04754.1 - 1.8e-44 152.3 0.0 2.7e-44 151.6 0.0 1.3 1 1 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Usp PF00582.26 EPA04756.1 - 1.4e-22 80.7 0.0 1.6e-22 80.6 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family SAD_SRA PF02182.17 EPA04756.1 - 0.2 11.4 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 SAD/SRA domain CorA PF01544.18 EPA04757.1 - 5.4e-68 229.4 1.9 6.3e-68 229.2 1.9 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF1993 PF09351.10 EPA04757.1 - 0.0092 16.1 0.1 0.27 11.4 0.1 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF1993) T3SchapCesA PF11439.8 EPA04757.1 - 0.029 14.5 1.9 0.15 12.2 0.9 2.6 2 1 0 2 2 2 0 Type III secretion system filament chaperone CesA TTRAP PF14203.6 EPA04757.1 - 0.12 12.4 1.7 2.1 8.4 0.1 2.7 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein DUF1664 PF07889.12 EPA04757.1 - 0.16 12.0 0.5 0.69 10.0 0.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3169 PF11368.8 EPA04757.1 - 0.2 11.2 5.1 0.27 10.7 4.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) MnmE_helical PF12631.7 EPA04757.1 - 0.22 11.7 2.2 1.8 8.6 0.4 2.1 1 1 1 2 2 2 0 MnmE helical domain Big_9 PF17963.1 EPA04759.1 - 7.9e-42 141.9 53.2 8.5e-21 74.5 18.8 4.8 4 1 0 4 4 4 3 Bacterial Ig domain Cadherin_4 PF17803.1 EPA04759.1 - 1.3e-28 99.4 50.2 3.9e-15 56.2 14.1 5.0 4 1 0 4 4 4 3 Bacterial cadherin-like domain Cadherin_5 PF17892.1 EPA04759.1 - 1.1e-22 79.8 32.0 1.5e-11 44.1 8.9 4.3 4 1 0 4 4 4 3 Cadherin-like domain Cu-binding_MopE PF11617.8 EPA04759.1 - 0.097 12.9 4.5 0.31 11.3 4.0 2.1 2 0 0 2 2 2 0 Putative metal-binding motif Cadherin_3 PF16184.5 EPA04759.1 - 0.12 12.4 5.2 0.89 9.6 0.0 3.5 3 1 0 3 3 3 0 Cadherin-like DUF3823 PF12866.7 EPA04759.1 - 0.2 12.0 1.8 5.1 7.5 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3823) N-terminal domain Invasin_D3 PF09134.10 EPA04759.1 - 7.8 6.9 18.6 2.2 8.7 3.4 3.9 3 1 0 3 3 3 0 Invasin, domain 3 Peptidase_M50 PF02163.22 EPA04762.1 - 1.1e-12 47.8 14.0 7.8e-09 35.2 0.4 2.8 1 1 1 2 2 2 2 Peptidase family M50 DUF3698 PF12479.8 EPA04762.1 - 0.019 15.5 0.5 0.054 14.0 0.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3698) Proton_antipo_M PF00361.20 EPA04763.1 - 4.7e-66 223.0 25.2 4.7e-66 223.0 25.2 2.4 1 1 1 2 2 2 1 Proton-conducting membrane transporter DUF5592 PF17332.2 EPA04763.1 - 0.24 12.0 0.1 0.24 12.0 0.1 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5592) polyprenyl_synt PF00348.17 EPA04765.1 - 1.3e-47 162.0 0.1 1.7e-47 161.6 0.1 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase NADH5_C PF06455.11 EPA04766.1 - 0.0012 18.4 1.4 0.0015 18.2 1.4 1.1 1 0 0 1 1 1 1 NADH dehydrogenase subunit 5 C-terminus TENA_THI-4 PF03070.16 EPA04767.1 - 3.9e-14 53.0 0.3 4.3e-14 52.8 0.3 1.0 1 0 0 1 1 1 1 TENA/THI-4/PQQC family Haem_oxygenas_2 PF14518.6 EPA04767.1 - 8.4e-13 48.5 0.0 1e-12 48.2 0.0 1.1 1 0 0 1 1 1 1 Iron-containing redox enzyme DUF2812 PF11193.8 EPA04767.1 - 0.0075 16.5 0.1 0.028 14.6 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2812) Phage_holin_3_6 PF07332.11 EPA04768.1 - 0.39 10.8 5.2 0.46 10.5 5.2 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2207 PF09972.9 EPA04768.1 - 1.3 7.7 4.0 1.5 7.5 4.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Met_10 PF02475.16 EPA04769.1 - 4.3e-05 23.4 0.0 5.7e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltr_RsmB-F PF01189.17 EPA04769.1 - 0.074 12.7 0.0 0.081 12.6 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Acetyltransf_1 PF00583.25 EPA04770.1 - 6.1e-20 71.6 0.2 7.7e-20 71.3 0.2 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EPA04770.1 - 1.7e-14 54.0 0.6 1.7e-14 54.0 0.6 1.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EPA04770.1 - 1.3e-12 47.8 0.3 1.9e-12 47.2 0.3 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EPA04770.1 - 1.2e-09 38.0 0.2 4.9e-09 36.0 0.1 1.8 1 1 1 2 2 2 1 FR47-like protein Acetyltransf_8 PF13523.6 EPA04770.1 - 0.00074 19.2 0.0 0.0025 17.5 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EPA04770.1 - 0.001 19.7 0.0 0.0014 19.3 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EPA04770.1 - 0.0015 18.2 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_9 PF13527.7 EPA04770.1 - 0.01 15.9 0.0 0.021 14.9 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EPA04770.1 - 0.011 15.9 0.3 0.014 15.5 0.3 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF4821 PF16092.5 EPA04770.1 - 0.015 15.0 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4821) Acetyltransf_CG PF14542.6 EPA04770.1 - 0.024 14.7 0.1 0.048 13.8 0.1 1.6 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase Pribosyltran PF00156.27 EPA04771.1 - 3.5e-15 55.9 0.2 4.7e-15 55.5 0.2 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 EPA04771.1 - 0.00036 20.1 0.1 0.00059 19.4 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase UPRTase PF14681.6 EPA04771.1 - 0.00055 19.4 0.3 0.00078 18.9 0.3 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase SmpB PF01668.18 EPA04771.1 - 0.0087 15.9 0.4 0.014 15.3 0.2 1.5 2 0 0 2 2 2 1 SmpB protein Big_9 PF17963.1 EPA04773.1 - 3.6e-20 72.5 24.3 9e-16 58.4 2.7 3.9 3 1 0 3 3 3 2 Bacterial Ig domain Cadherin_4 PF17803.1 EPA04773.1 - 2.7e-13 50.3 23.8 4.2e-09 36.9 1.4 4.2 3 1 0 3 3 3 2 Bacterial cadherin-like domain Cadherin_5 PF17892.1 EPA04773.1 - 4.5e-11 42.6 14.4 4.6e-11 42.6 1.8 3.5 3 1 0 3 3 3 2 Cadherin-like domain Cu-binding_MopE PF11617.8 EPA04773.1 - 0.27 11.4 6.2 0.46 10.7 4.6 2.2 2 0 0 2 2 2 0 Putative metal-binding motif Ribosomal_L3 PF00297.22 EPA04775.1 - 5.5e-71 239.5 2.0 1.2e-69 235.1 2.0 2.0 1 1 0 1 1 1 1 Ribosomal protein L3 DUF371 PF04027.13 EPA04776.1 - 1.2e-45 154.8 0.1 1.3e-45 154.6 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF371) Ribosomal_L14 PF00238.19 EPA04777.1 - 2.8e-31 108.1 1.3 3.2e-31 107.9 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Ribosomal_L22 PF00237.19 EPA04778.1 - 3.1e-06 27.4 0.2 4e-06 27.0 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ribosomal_L29 PF00831.23 EPA04779.1 - 1.2e-11 44.4 3.2 1.4e-11 44.2 3.2 1.1 1 0 0 1 1 1 1 Ribosomal L29 protein Ribosomal_S19 PF00203.21 EPA04780.1 - 2e-27 94.9 0.1 2.7e-27 94.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 UPF0086 PF01868.16 EPA04781.1 - 3.5e-20 71.7 0.0 3.9e-20 71.6 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Snf7 PF03357.21 EPA04782.1 - 0.017 14.7 1.2 0.027 14.1 1.2 1.5 1 1 0 1 1 1 0 Snf7 bPH_4 PF06713.11 EPA04782.1 - 0.12 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial PH domain Ribosomal_S3_C PF00189.20 EPA04783.1 - 2e-20 73.1 0.9 4.6e-20 71.9 0.9 1.7 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EPA04783.1 - 3.3e-13 49.3 0.0 8.7e-13 47.9 0.0 1.8 1 0 0 1 1 1 1 KH domain KH_1 PF00013.29 EPA04783.1 - 0.03 14.1 0.1 0.44 10.4 0.0 2.4 2 0 0 2 2 2 0 KH domain Ribosomal_L26 PF16906.5 EPA04784.1 - 2.9e-18 66.1 0.4 4.6e-18 65.5 0.4 1.3 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EPA04784.1 - 1.3e-05 24.9 0.7 3.2e-05 23.7 0.7 1.7 1 0 0 1 1 1 1 KOW motif Methyltrans_RNA PF04452.14 EPA04784.1 - 0.031 13.6 0.5 0.051 12.9 0.2 1.4 1 1 0 1 1 1 0 RNA methyltransferase Ribosomal_S17 PF00366.20 EPA04785.1 - 4.8e-18 65.0 1.3 6.1e-18 64.7 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_S17_N PF16205.5 EPA04785.1 - 0.0013 19.0 0.2 0.0033 17.8 0.0 1.8 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_L4 PF00573.22 EPA04786.1 - 6.9e-40 136.8 0.1 8e-40 136.6 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Proteasome PF00227.26 EPA04787.1 - 3.5e-52 176.7 0.3 4.5e-52 176.3 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EPA04787.1 - 3.6e-14 52.1 0.7 1.4e-13 50.2 0.1 2.2 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature WbqC PF08889.11 EPA04788.1 - 0.026 14.4 0.7 0.032 14.2 0.7 1.2 1 0 0 1 1 1 0 WbqC-like protein family Ribosomal_L22 PF00237.19 EPA04789.1 - 7.1e-18 64.8 0.0 7.3e-18 64.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Herpes_UL36 PF03586.13 EPA04789.1 - 0.071 12.4 0.0 0.073 12.4 0.0 1.0 1 0 0 1 1 1 0 Herpesvirus UL36 tegument protein Ribosomal_L23 PF00276.20 EPA04790.1 - 1.9e-13 50.6 0.9 3.3e-13 49.8 0.9 1.4 1 1 0 1 1 1 1 Ribosomal protein L23 DNA_mis_repair PF01119.19 EPA04790.1 - 0.012 15.3 0.1 0.017 14.8 0.0 1.3 1 1 0 1 1 1 0 DNA mismatch repair protein, C-terminal domain MuF_C PF18819.1 EPA04790.1 - 0.1 12.6 0.1 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 Phage MuF-C-terminal domain Methyltrn_RNA_3 PF02598.17 EPA04791.1 - 5.1e-52 177.1 0.0 5.8e-52 177.0 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase Ribosomal_S4e PF00900.20 EPA04792.1 - 9e-18 64.0 0.2 1.5e-17 63.2 0.2 1.4 1 0 0 1 1 1 1 Ribosomal family S4e RS4NT PF08071.12 EPA04792.1 - 1.6e-12 47.3 0.5 2.6e-12 46.6 0.5 1.3 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 EPA04792.1 - 0.0015 18.2 0.1 0.0034 17.1 0.1 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EPA04792.1 - 0.02 14.8 0.1 0.091 12.7 0.0 2.2 2 0 0 2 2 2 0 KOW motif Cupredoxin_1 PF13473.6 EPA04793.1 - 2.2e-05 24.5 0.0 3.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Cupredoxin-like domain Arch_flagellin PF01917.16 EPA04793.1 - 0.14 12.3 2.6 5.9 7.0 1.3 2.3 2 1 0 2 2 2 0 Archaebacterial flagellin Transketolase_N PF00456.21 EPA04795.1 - 1.2e-50 172.4 0.4 2.7e-49 167.9 0.4 2.1 1 1 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Ribul_P_3_epim PF00834.19 EPA04795.1 - 7.3e-29 100.6 0.2 1e-28 100.1 0.2 1.2 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family DXP_synthase_N PF13292.6 EPA04795.1 - 5e-06 25.9 0.1 4.7e-05 22.7 0.1 2.1 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 EPA04795.1 - 5.7e-06 25.5 0.0 9e-06 24.8 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EPA04795.1 - 1.2e-05 25.2 0.0 2.6e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain XFP_N PF09364.10 EPA04795.1 - 3.4e-05 22.8 0.2 0.00046 19.1 0.0 2.1 2 0 0 2 2 2 1 XFP N-terminal domain DUF393 PF04134.12 EPA04796.1 - 0.00084 20.7 0.0 0.0011 20.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF393 Peptidase_M17 PF00883.21 EPA04797.1 - 1.3e-119 399.1 0.0 1.7e-119 398.7 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 EPA04797.1 - 7.9e-17 61.3 0.2 2.7e-16 59.6 0.0 2.0 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain Peptidase_M17 PF00883.21 EPA04798.1 - 3.1e-120 401.1 0.0 3.5e-120 401.0 0.0 1.0 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain DUF2746 PF10874.8 EPA04798.1 - 0.18 12.3 0.0 0.37 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) Iso_dh PF00180.20 EPA04799.1 - 7.8e-102 341.0 0.4 8.7e-102 340.8 0.4 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PdxA PF04166.12 EPA04799.1 - 0.00068 19.1 0.0 0.0013 18.2 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal phosphate biosynthetic protein PdxA TRL PF13146.6 EPA04799.1 - 0.036 14.3 0.1 0.078 13.3 0.1 1.5 1 0 0 1 1 1 0 TRL-like protein family LeuA_dimer PF08502.10 EPA04801.1 - 4.8e-30 104.2 1.2 6.5e-30 103.7 1.2 1.2 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain DUF4147 PF13660.6 EPA04801.1 - 0.006 16.1 0.1 0.015 14.9 0.1 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4147) UPF0154 PF03672.13 EPA04801.1 - 0.29 11.2 2.0 0.46 10.5 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) GatB_Yqey PF02637.18 EPA04802.1 - 2.4e-19 69.7 7.0 2.4e-19 69.7 7.0 2.2 2 0 0 2 2 2 1 GatB domain GatB_N PF02934.15 EPA04802.1 - 3.3e-05 23.4 0.3 8.3e-05 22.1 0.0 1.7 2 0 0 2 2 2 1 GatB/GatE catalytic domain GAD PF02938.14 EPA04802.1 - 0.00029 21.0 0.2 0.0011 19.1 0.0 2.1 2 0 0 2 2 2 1 GAD domain Dimeth_Pyl PF09505.10 EPA04802.1 - 0.028 13.0 0.7 0.039 12.5 0.7 1.1 1 0 0 1 1 1 0 Dimethylamine methyltransferase (Dimeth_PyL) Hist_deacetyl PF00850.19 EPA04802.1 - 0.21 11.0 0.0 0.35 10.3 0.0 1.3 1 0 0 1 1 1 0 Histone deacetylase domain Glycos_trans_3N PF02885.17 EPA04802.1 - 0.43 10.5 3.2 5.6 6.9 0.1 2.8 2 1 1 3 3 3 0 Glycosyl transferase family, helical bundle domain DnaJ_C PF01556.18 EPA04803.1 - 5.4e-38 130.4 0.5 7.7e-38 129.9 0.5 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EPA04803.1 - 1.3e-26 92.4 1.5 2.2e-26 91.7 1.5 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EPA04803.1 - 8.2e-13 48.5 19.4 1.5e-12 47.7 19.4 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EPA04803.1 - 3.1 7.8 20.0 6.2 6.9 5.2 2.9 1 1 2 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein VWA_N2 PF16164.5 EPA04803.1 - 5.7 7.1 11.7 0.3 11.2 3.4 2.2 1 1 1 2 2 2 0 VWA N-terminal Asparaginase PF00710.20 EPA04804.1 - 1.6e-53 181.1 0.1 2.2e-53 180.6 0.1 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EPA04804.1 - 1.2e-28 99.6 0.0 2.4e-28 98.6 0.0 1.5 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain HSP70 PF00012.20 EPA04805.1 - 6.1e-184 612.5 8.3 8e-184 612.2 8.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EPA04805.1 - 7.1e-17 61.2 2.4 1.6e-16 60.1 2.4 1.5 1 1 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.16 EPA04805.1 - 0.00068 19.4 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Raco_middle PF17651.1 EPA04805.1 - 0.017 14.8 0.0 0.076 12.7 0.0 2.1 1 1 0 1 1 1 0 RACo middle region StbA PF06406.11 EPA04805.1 - 0.022 14.0 1.0 0.34 10.1 0.3 2.1 1 1 1 2 2 2 0 StbA protein Peptidase_M22 PF00814.25 EPA04805.1 - 0.13 12.0 0.1 0.31 10.7 0.0 1.6 2 0 0 2 2 2 0 Glycoprotease family DUF4065 PF13274.6 EPA04805.1 - 0.23 12.3 2.2 13 6.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4065) NT5C PF06941.12 EPA04807.1 - 4.8e-13 49.4 1.7 5.8e-13 49.1 1.7 1.1 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) GatB_N PF02934.15 EPA04808.1 - 2.7e-35 122.1 0.0 3.3e-35 121.8 0.0 1.0 1 0 0 1 1 1 1 GatB/GatE catalytic domain TPR_1 PF00515.28 EPA04810.1 - 9.4e-06 25.2 1.2 0.0037 17.0 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EPA04810.1 - 1.1e-05 25.0 0.2 1.5e-05 24.6 0.2 1.1 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.17 EPA04810.1 - 7.8e-05 22.5 0.1 0.0019 18.1 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EPA04810.1 - 0.00021 21.9 0.0 0.00026 21.6 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 EPA04810.1 - 0.00074 20.0 0.0 0.001 19.5 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 EPA04810.1 - 0.00075 19.7 1.9 0.0023 18.2 0.2 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EPA04810.1 - 0.0026 18.3 0.1 0.044 14.4 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EPA04810.1 - 0.0035 18.0 0.0 0.0041 17.7 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EPA04810.1 - 0.0053 16.9 0.0 0.0056 16.9 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EPA04810.1 - 0.0056 16.8 0.4 0.35 11.2 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat HemolysinCabind PF00353.19 EPA04812.1 - 1.6e-44 149.4 119.3 1.1e-10 41.2 16.2 4.5 1 1 5 6 6 6 6 RTX calcium-binding nonapeptide repeat (4 copies) Ephrin_rec_like PF07699.13 EPA04812.1 - 0.00025 20.7 2.6 0.023 14.5 0.5 3.0 1 1 2 3 3 3 3 Putative ephrin-receptor like NHL PF01436.21 EPA04812.1 - 0.0021 18.0 0.1 0.0041 17.1 0.1 1.5 1 0 0 1 1 1 1 NHL repeat DUF167 PF02594.16 EPA04813.1 - 3.6e-16 59.0 0.9 3.9e-16 58.9 0.9 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 MinE PF03776.14 EPA04813.1 - 0.001 19.0 1.1 0.0067 16.4 0.3 2.0 1 1 1 2 2 2 1 Septum formation topological specificity factor MinE Acylphosphatase PF00708.18 EPA04814.1 - 8.2e-16 58.2 0.1 8.8e-16 58.1 0.1 1.0 1 0 0 1 1 1 1 Acylphosphatase Ribosomal_L2_C PF03947.18 EPA04815.1 - 7.9e-35 119.8 2.8 1.3e-34 119.1 2.8 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EPA04815.1 - 9.5e-09 35.1 0.0 3.1e-08 33.5 0.0 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain RecR PF02132.15 EPA04816.1 - 0.25 10.9 4.2 0.88 9.2 4.1 2.1 2 0 0 2 2 2 0 RecR protein CDC48_N PF02359.18 EPA04818.1 - 9.1e-31 105.9 0.1 3.2e-30 104.1 0.2 1.8 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain AAA PF00004.29 EPA04818.1 - 1e-28 100.4 0.0 1.7e-28 99.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.17 EPA04818.1 - 4.1e-09 36.1 0.1 8.5e-09 35.1 0.1 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 RuvB_N PF05496.12 EPA04818.1 - 4e-08 33.2 0.0 6.3e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EPA04818.1 - 6.7e-06 26.6 0.1 8.2e-05 23.0 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 EPA04818.1 - 2.7e-05 23.6 0.1 6.8e-05 22.2 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 EPA04818.1 - 0.00012 22.4 0.0 0.0014 18.9 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EPA04818.1 - 0.00022 21.2 0.2 0.0028 17.7 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EPA04818.1 - 0.00023 21.3 0.0 0.00047 20.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EPA04818.1 - 0.00059 19.9 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EPA04818.1 - 0.00077 19.6 0.0 0.0012 19.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EPA04818.1 - 0.0013 18.5 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.6 EPA04818.1 - 0.0054 17.0 0.0 0.0092 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EPA04818.1 - 0.0056 17.0 0.0 0.013 15.9 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 EPA04818.1 - 0.0064 16.0 0.0 0.011 15.2 0.0 1.5 1 1 0 1 1 1 1 P-loop containing dynein motor region Sigma54_activat PF00158.26 EPA04818.1 - 0.0069 16.1 0.0 0.017 14.9 0.0 1.7 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 EPA04818.1 - 0.0072 15.7 0.1 0.013 14.9 0.1 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EPA04818.1 - 0.0092 15.3 0.0 0.024 13.9 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 EPA04818.1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EPA04818.1 - 0.013 14.8 0.1 0.038 13.3 0.0 1.6 1 1 0 1 1 1 0 KaiC AAA_18 PF13238.6 EPA04818.1 - 0.022 15.3 0.0 0.037 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EPA04818.1 - 0.028 13.6 0.0 0.037 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TsaE PF02367.17 EPA04818.1 - 0.038 14.0 0.0 0.064 13.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EPA04818.1 - 0.057 12.6 0.0 0.091 11.9 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Parvo_NS1 PF01057.17 EPA04818.1 - 0.059 12.5 0.0 0.09 11.8 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 EPA04818.1 - 0.059 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.9 EPA04818.1 - 0.062 12.5 0.0 0.11 11.7 0.0 1.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 EPA04818.1 - 0.085 12.8 0.1 0.24 11.3 0.0 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 EPA04818.1 - 0.11 13.0 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_25 PF13481.6 EPA04818.1 - 0.16 11.6 0.0 0.35 10.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EPA04818.1 - 0.16 11.8 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EPA04818.1 - 0.19 11.5 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain TSP_3 PF02412.18 EPA04819.1 - 2.8e-10 39.7 33.1 0.00021 20.9 2.1 5.5 7 0 0 7 7 7 3 Thrombospondin type 3 repeat DUF282 PF03380.14 EPA04819.1 - 0.02 14.8 1.5 4.7 7.2 0.1 2.8 2 0 0 2 2 2 0 Caenorhabditis protein of unknown function, DUF282 Excalibur PF05901.11 EPA04819.1 - 0.57 10.8 7.8 8.6 7.1 0.0 3.9 5 0 0 5 5 5 0 Excalibur calcium-binding domain VCBS PF13517.6 EPA04819.1 - 2.2 8.9 7.4 5.6 7.6 0.4 3.2 2 2 1 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TSP_3 PF02412.18 EPA04820.1 - 5e-15 54.9 39.2 0.00012 21.6 0.6 5.9 5 2 1 6 6 6 4 Thrombospondin type 3 repeat Excalibur PF05901.11 EPA04820.1 - 0.025 15.2 11.7 4.2 8.1 0.3 4.4 4 1 0 4 4 4 0 Excalibur calcium-binding domain DUF282 PF03380.14 EPA04820.1 - 0.082 12.8 4.3 32 4.5 0.0 4.5 5 0 0 5 5 5 0 Caenorhabditis protein of unknown function, DUF282 GlutR_dimer PF00745.20 EPA04821.1 - 0.00011 22.6 0.0 0.00012 22.5 0.0 1.1 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain ALAD PF00490.21 EPA04822.1 - 2e-66 224.4 0.4 2.2e-66 224.2 0.4 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase NADHdh PF00146.21 EPA04823.1 - 9.8e-26 90.7 4.4 9.8e-26 90.7 4.4 1.4 2 0 0 2 2 2 1 NADH dehydrogenase NDUF_B12 PF08122.12 EPA04823.1 - 0.12 12.4 0.3 0.12 12.4 0.3 2.3 2 1 1 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family Complex1_49kDa PF00346.19 EPA04824.1 - 1.6e-29 102.8 0.0 1.3e-15 57.3 0.0 2.0 1 1 1 2 2 2 2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Ribosomal_S5_C PF03719.15 EPA04824.1 - 0.039 13.4 0.1 0.063 12.7 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein S5, C-terminal domain Lyase_1 PF00206.20 EPA04825.1 - 8.7e-24 84.5 0.1 1.6e-22 80.3 0.0 2.3 2 0 0 2 2 2 1 Lyase ASL_C2 PF14698.6 EPA04825.1 - 1.7e-13 51.1 0.0 3.2e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal CTP_transf_like PF01467.26 EPA04826.1 - 0.023 14.9 0.0 0.039 14.1 0.0 1.7 1 1 0 1 1 1 0 Cytidylyltransferase-like Ntox35 PF15534.6 EPA04826.1 - 0.33 11.4 2.3 4.8 7.7 0.1 2.4 2 0 0 2 2 2 0 Bacterial toxin 35 Biotin_lipoyl PF00364.22 EPA04827.1 - 9.5e-17 60.6 4.6 1.7e-16 59.8 4.6 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EPA04827.1 - 2.7e-10 39.9 2.7 1.6e-09 37.4 0.3 2.4 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 EPA04827.1 - 9.7e-05 23.0 0.5 0.033 14.9 0.1 2.5 1 1 1 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 EPA04827.1 - 0.0011 18.3 1.8 0.061 12.5 0.1 2.7 2 1 1 3 3 3 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion RnfC_N PF13375.6 EPA04827.1 - 0.004 17.1 1.5 0.0078 16.2 1.5 1.5 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain GCV_H PF01597.19 EPA04827.1 - 0.014 15.3 0.6 0.032 14.1 0.6 1.7 1 0 0 1 1 1 0 Glycine cleavage H-protein Big_3_3 PF13750.6 EPA04827.1 - 0.017 14.8 2.0 0.036 13.7 0.7 2.0 1 1 1 2 2 2 0 Bacterial Ig-like domain (group 3) QRPTase_N PF02749.16 EPA04827.1 - 0.022 14.8 0.1 0.074 13.1 0.0 1.9 1 1 1 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain DUF2118 PF09891.9 EPA04827.1 - 0.033 14.1 0.6 0.057 13.4 0.1 1.6 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) DUF4164 PF13747.6 EPA04827.1 - 0.055 13.8 0.0 0.083 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Peptidase_M23 PF01551.22 EPA04827.1 - 0.076 13.2 2.0 0.76 10.0 0.2 2.6 2 1 1 3 3 3 0 Peptidase family M23 eIF-1a PF01176.19 EPA04827.1 - 0.077 12.8 0.3 1.4 8.8 0.0 2.7 2 1 0 2 2 2 0 Translation initiation factor 1A / IF-1 Complex1_30kDa PF00329.19 EPA04828.1 - 1e-34 119.8 0.0 1.3e-34 119.5 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit Alkyl_sulf_dimr PF14863.6 EPA04828.1 - 0.22 12.0 0.0 1.1 9.8 0.0 1.9 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation MEF2_binding PF09047.10 EPA04830.1 - 0.047 13.5 10.5 0.42 10.5 1.0 2.8 2 0 0 2 2 2 0 MEF2 binding Herpes_UL17 PF04559.12 EPA04830.1 - 0.26 10.0 3.8 0.31 9.8 3.8 1.2 1 0 0 1 1 1 0 Herpesvirus UL17 protein DivIVA PF05103.13 EPA04830.1 - 8.3 6.5 18.3 7 6.7 0.1 2.3 2 0 0 2 2 2 0 DivIVA protein Glycos_transf_4 PF00953.21 EPA04831.1 - 9.9e-27 93.9 11.6 9.9e-27 93.9 11.6 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 4 DUF2254 PF10011.9 EPA04831.1 - 0.032 13.1 0.9 0.058 12.2 0.9 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) DUF3043 PF11241.8 EPA04831.1 - 7.2 6.6 7.1 4.1 7.4 0.0 2.9 3 1 1 4 4 4 0 Protein of unknown function (DUF3043) Hexapep PF00132.24 EPA04832.1 - 4.1e-27 92.9 20.1 1.7e-11 43.4 1.3 4.4 4 1 1 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EPA04832.1 - 3.6e-19 68.2 12.6 1.7e-11 43.6 2.6 4.5 5 0 0 5 5 5 3 Hexapeptide repeat of succinyl-transferase RuvX PF03652.15 EPA04832.1 - 0.12 12.8 0.2 0.15 12.4 0.2 1.1 1 0 0 1 1 1 0 Holliday junction resolvase DUF1059 PF06348.11 EPA04833.1 - 1.8e-06 28.0 0.1 1.9e-06 28.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) Fer2_BFD PF04324.15 EPA04833.1 - 0.078 13.3 0.0 0.093 13.1 0.0 1.2 1 0 0 1 1 1 0 BFD-like [2Fe-2S] binding domain Trm112p PF03966.16 EPA04834.1 - 2.7e-08 34.3 0.2 7.8e-08 32.8 0.2 1.8 1 1 0 1 1 1 1 Trm112p-like protein Cys_rich_KTR PF14205.6 EPA04834.1 - 0.062 13.1 0.4 0.12 12.2 0.4 1.6 1 1 0 1 1 1 0 Cysteine-rich KTR HEAT_2 PF13646.6 EPA04835.1 - 3.5e-17 62.5 0.5 7.9e-08 32.6 0.1 2.5 1 1 2 3 3 3 3 HEAT repeats HEAT PF02985.22 EPA04835.1 - 7.8e-11 41.3 0.1 0.0032 17.6 0.0 4.2 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.7 EPA04835.1 - 7.1e-06 26.2 2.6 0.42 10.6 0.0 3.2 1 1 2 3 3 3 3 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.7 EPA04835.1 - 2e-05 24.8 1.5 0.52 10.7 0.0 4.0 4 1 0 4 4 4 2 HEAT repeat associated with sister chromatid cohesion HEAT_EZ PF13513.6 EPA04835.1 - 2.3e-05 24.8 0.0 0.094 13.2 0.0 3.3 3 0 0 3 3 3 1 HEAT-like repeat ERAP1_C PF11838.8 EPA04835.1 - 0.0003 20.4 0.2 0.1 12.1 0.0 2.2 1 1 1 2 2 2 2 ERAP1-like C-terminal domain DNA_pol3_delta PF06144.13 EPA04835.1 - 0.0018 18.1 0.9 0.35 10.6 0.1 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit HEAT_PBS PF03130.16 EPA04835.1 - 0.028 15.1 0.0 26 5.9 0.1 4.2 5 1 0 5 5 5 0 PBS lyase HEAT-like repeat CLASP_N PF12348.8 EPA04835.1 - 0.029 13.9 0.1 0.094 12.3 0.1 2.0 1 1 1 2 2 2 0 CLASP N terminal DUF4042 PF13251.6 EPA04835.1 - 0.045 13.5 0.0 7.2 6.3 0.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4042) V-ATPase_H_C PF11698.8 EPA04835.1 - 0.057 13.5 3.1 0.34 11.0 0.2 2.7 2 1 1 3 3 3 0 V-ATPase subunit H FeS_assembly_P PF01883.19 EPA04836.1 - 1.2e-15 57.5 0.1 1.7e-15 57.0 0.1 1.3 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein HMA PF00403.26 EPA04836.1 - 0.1 13.1 2.3 0.41 11.1 0.1 2.4 2 1 1 3 3 3 0 Heavy-metal-associated domain AAA PF00004.29 EPA04837.1 - 1.4e-12 48.2 0.0 4e-12 46.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EPA04837.1 - 3.9e-08 33.2 0.0 1.3e-07 31.5 0.0 1.9 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 EPA04837.1 - 1.1e-05 25.4 0.4 5.1e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain TIP49 PF06068.13 EPA04837.1 - 0.00078 18.7 0.0 0.0013 18.0 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 EPA04837.1 - 0.0029 17.6 0.0 0.0083 16.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EPA04837.1 - 0.0073 16.3 0.1 0.051 13.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EPA04837.1 - 0.0093 16.2 0.3 0.34 11.2 0.1 2.8 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 EPA04837.1 - 0.01 16.2 0.0 0.022 15.2 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EPA04837.1 - 0.012 15.2 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_2 PF07724.14 EPA04837.1 - 0.018 15.2 0.0 0.038 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EPA04837.1 - 0.027 14.6 0.0 0.054 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EPA04837.1 - 0.028 14.4 0.0 0.07 13.0 0.0 1.7 1 0 0 1 1 1 0 NTPase RFC1 PF08519.12 EPA04837.1 - 0.029 14.5 0.5 0.059 13.5 0.1 1.8 2 0 0 2 2 2 0 Replication factor RFC1 C terminal domain Mg_chelatase PF01078.21 EPA04837.1 - 0.031 13.7 0.3 0.12 11.8 0.0 2.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI TniB PF05621.11 EPA04837.1 - 0.054 12.9 0.1 3.2 7.1 0.0 2.9 2 1 1 3 3 3 0 Bacterial TniB protein AAA_18 PF13238.6 EPA04837.1 - 0.056 14.0 0.1 0.2 12.2 0.0 1.9 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EPA04837.1 - 0.056 13.1 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EPA04837.1 - 0.096 13.1 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EPA04837.1 - 0.1 11.8 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin IstB_IS21 PF01695.17 EPA04837.1 - 0.11 12.2 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AhpC-TSA PF00578.21 EPA04838.1 - 3.9e-33 114.0 0.0 4.6e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EPA04838.1 - 2.9e-21 75.7 0.0 3.4e-21 75.5 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 EPA04838.1 - 0.083 13.0 0.0 0.25 11.5 0.0 1.6 1 1 0 2 2 2 0 AhpC/TSA antioxidant enzyme SCO1-SenC PF02630.14 EPA04838.1 - 0.12 12.3 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 SCO1/SenC Fer2_3 PF13085.6 EPA04839.1 - 7.9e-31 106.3 0.0 1.7e-30 105.3 0.0 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.6 EPA04839.1 - 5.4e-12 46.0 4.6 7.1e-12 45.6 2.2 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EPA04839.1 - 1.7e-10 40.8 2.5 1.7e-10 40.8 2.5 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EPA04839.1 - 3.2e-09 37.2 13.0 2.1e-07 31.4 3.9 2.7 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 EPA04839.1 - 3.7e-09 37.0 12.4 2.1e-07 31.4 3.3 2.5 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EPA04839.1 - 3.4e-08 33.5 12.1 2.9e-07 30.5 3.0 2.5 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 EPA04839.1 - 5.4e-07 30.5 2.5 5.4e-07 30.5 2.5 2.1 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain Fer4_18 PF13746.6 EPA04839.1 - 1e-05 25.7 4.5 0.029 14.6 0.2 2.7 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4 PF00037.27 EPA04839.1 - 3.8e-05 23.3 1.1 3.8e-05 23.3 1.1 3.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer2 PF00111.27 EPA04839.1 - 0.00022 21.1 0.1 0.00022 21.1 0.1 1.8 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_6 PF12837.7 EPA04839.1 - 0.0021 18.1 1.8 0.0021 18.1 1.8 2.9 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_2 PF12797.7 EPA04839.1 - 0.024 14.7 2.0 0.024 14.7 2.0 3.4 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_4 PF12800.7 EPA04839.1 - 0.087 13.4 1.3 0.087 13.4 1.3 3.1 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_21 PF14697.6 EPA04839.1 - 0.13 12.4 13.1 0.081 13.1 7.7 2.8 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 EPA04839.1 - 0.87 10.7 21.4 0.38 11.8 4.6 3.2 3 1 0 3 3 3 0 4Fe-4S binding domain Inositol_P PF00459.25 EPA04841.1 - 7.3e-28 97.8 0.0 8.8e-28 97.6 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.20 EPA04841.1 - 0.00035 20.1 0.1 0.0006 19.4 0.1 1.3 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Lyase_1 PF00206.20 EPA04842.1 - 6.3e-06 25.8 0.6 7.5e-06 25.5 0.6 1.1 1 0 0 1 1 1 1 Lyase SMP_C2CD2L PF18696.1 EPA04842.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Synaptotagmin-like, mitochondrial and lipid-binding domain Aminotran_4 PF01063.19 EPA04843.1 - 6.2e-45 153.8 0.0 7.4e-45 153.5 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV DUF22 PF01629.16 EPA04843.1 - 0.026 14.2 0.1 0.051 13.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF22 Sdh_cyt PF01127.22 EPA04844.1 - 1.5e-07 31.5 3.0 1.8e-07 31.2 3.0 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Fumarate_red_D PF02313.17 EPA04844.1 - 0.11 12.6 3.9 0.15 12.2 3.9 1.3 1 0 0 1 1 1 0 Fumarate reductase subunit D DUF4179 PF13786.6 EPA04844.1 - 0.28 11.7 2.2 0.83 10.2 0.2 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) CPSase_L_D2 PF02786.17 EPA04845.1 - 5.3e-69 231.9 0.0 7.9e-69 231.4 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EPA04845.1 - 1.8e-45 154.0 0.1 3.3e-45 153.1 0.1 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EPA04845.1 - 1.8e-33 114.8 0.0 4e-33 113.7 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp PF02222.22 EPA04845.1 - 2.9e-10 40.0 0.1 5.7e-10 39.0 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EPA04845.1 - 6.2e-08 32.4 0.2 1.5e-07 31.2 0.2 1.5 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus RimK PF08443.11 EPA04845.1 - 1.2e-06 28.3 0.0 6.4e-06 25.9 0.0 2.0 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 EPA04845.1 - 1.9e-06 28.0 0.0 4.5e-06 26.8 0.0 1.7 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 EPA04845.1 - 1.2e-05 24.9 0.1 4.6e-05 23.1 0.1 1.9 2 0 0 2 2 2 1 ATP-grasp domain KRTDAP PF15200.6 EPA04845.1 - 0.026 14.3 0.0 0.083 12.7 0.0 1.8 2 0 0 2 2 2 0 Keratinocyte differentiation-associated ATPgrasp_Ter PF15632.6 EPA04845.1 - 0.058 13.1 0.0 0.55 10.0 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon GARS_A PF01071.19 EPA04845.1 - 0.11 12.3 0.4 0.4 10.4 0.0 2.1 3 0 0 3 3 3 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain LpxI_N PF17930.1 EPA04845.1 - 0.15 12.0 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 LpxI N-terminal domain NAD_binding_1 PF00175.21 EPA04846.1 - 6.2e-14 52.6 0.0 1e-13 51.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EPA04846.1 - 9.5e-08 32.3 0.0 1.6e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EPA04846.1 - 0.045 13.9 0.1 0.16 12.1 0.1 1.9 1 1 1 2 2 2 0 Ferric reductase NAD binding domain Methyltransf_34 PF11312.8 EPA04846.1 - 0.048 12.9 0.0 0.063 12.5 0.0 1.1 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase NAD_binding_1 PF00175.21 EPA04847.1 - 7.8e-11 42.6 0.0 1.6e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EPA04847.1 - 2.8e-08 34.0 0.0 4.5e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Methyltransf_34 PF11312.8 EPA04847.1 - 0.017 14.4 0.0 0.021 14.1 0.0 1.1 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase NAD_binding_6 PF08030.12 EPA04847.1 - 0.043 13.9 0.2 0.14 12.2 0.0 1.9 1 1 1 2 2 2 0 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EPA04847.1 - 0.19 12.0 0.0 0.29 11.4 0.0 1.3 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain Carboxyl_trans PF01039.22 EPA04848.1 - 4.5e-184 612.7 0.0 5.1e-184 612.5 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 EPA04848.1 - 8.4e-07 28.7 0.0 1.6e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Malonate decarboxylase gamma subunit (MdcE) DUF4212 PF13937.6 EPA04849.1 - 1.1 9.7 9.8 1.4 9.4 9.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4212) MFS_1 PF07690.16 EPA04850.1 - 1.5e-34 119.5 28.0 1.5e-34 119.5 28.0 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EPA04850.1 - 4.6e-32 111.5 30.8 5.9e-20 71.6 11.1 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.6 EPA04850.1 - 2.4e-10 39.6 17.4 3.7e-10 38.9 17.4 1.3 1 0 0 1 1 1 1 MFS/sugar transport protein FPN1 PF06963.12 EPA04850.1 - 0.00048 18.8 5.2 0.00095 17.8 0.6 2.3 2 0 0 2 2 2 1 Ferroportin1 (FPN1) MFS_5 PF05631.14 EPA04850.1 - 0.0013 17.8 7.9 0.0094 14.9 1.4 2.6 2 2 0 2 2 2 2 Sugar-tranasporters, 12 TM MFS_1_like PF12832.7 EPA04850.1 - 0.0039 16.1 4.6 0.0039 16.1 4.6 2.8 2 1 1 3 3 3 1 MFS_1 like family Complex1_49kDa PF00346.19 EPA04851.1 - 1.4e-38 132.5 0.0 2e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Oxidored_q6 PF01058.22 EPA04852.1 - 7.2e-25 87.3 0.1 1e-24 86.9 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit PadR PF03551.14 EPA04853.1 - 4.3e-11 42.6 0.1 7.9e-11 41.8 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_45 PF14947.6 EPA04853.1 - 1.5e-05 24.9 0.5 0.00021 21.2 0.1 2.4 2 0 0 2 2 2 1 Winged helix-turn-helix RTP PF02334.16 EPA04853.1 - 0.00088 19.9 0.2 0.025 15.2 0.0 2.3 1 1 1 2 2 2 1 Replication terminator protein Mrr_N PF14338.6 EPA04853.1 - 0.014 15.5 0.4 0.12 12.5 0.1 2.4 3 0 0 3 3 3 0 Mrr N-terminal domain Sdh_cyt PF01127.22 EPA04854.1 - 1e-07 32.0 4.7 2.2e-07 30.9 4.7 1.6 1 1 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Fumarate_red_D PF02313.17 EPA04854.1 - 0.011 15.9 2.3 0.081 13.0 0.0 2.2 2 0 0 2 2 2 0 Fumarate reductase subunit D Fumarate_red_C PF02300.17 EPA04854.1 - 0.32 11.1 4.1 0.1 12.7 0.8 1.7 2 0 0 2 2 2 0 Fumarate reductase subunit C Oxidored_q4 PF00507.19 EPA04856.1 - 5.5e-18 65.0 0.9 5.5e-18 65.0 0.9 1.5 1 1 1 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 MPS-4 PF17523.2 EPA04856.1 - 0.075 13.2 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 GlutR_N PF05201.15 EPA04858.1 - 1.7e-25 89.5 0.0 2.8e-25 88.8 0.0 1.3 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.20 EPA04858.1 - 6.9e-19 68.3 0.0 2.9e-18 66.3 0.0 2.0 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 EPA04858.1 - 0.019 15.4 0.0 0.048 14.1 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding F420_oxidored PF03807.17 EPA04858.1 - 0.05 14.2 0.0 0.1 13.2 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent K_oxygenase PF13434.6 EPA04858.1 - 0.066 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) PEP_mutase PF13714.6 EPA04859.1 - 3.5e-50 170.7 0.0 4.1e-50 170.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 EPA04859.1 - 5.9e-15 54.7 0.1 2.2e-14 52.8 0.0 1.7 2 0 0 2 2 2 1 Isocitrate lyase family FAD_binding_2 PF00890.24 EPA04860.1 - 2.3e-98 330.0 0.1 2.9e-98 329.7 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EPA04860.1 - 3e-37 127.5 0.6 4.8e-37 126.8 0.6 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 EPA04860.1 - 3e-07 30.0 0.0 0.00048 19.5 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EPA04860.1 - 0.00082 18.6 0.0 0.045 12.8 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EPA04860.1 - 0.0013 18.2 0.0 0.061 12.7 0.1 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EPA04860.1 - 0.0014 18.0 0.2 0.0051 16.1 0.1 2.0 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 EPA04860.1 - 0.034 13.2 0.1 0.062 12.3 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein DAO PF01266.24 EPA04860.1 - 0.043 13.4 0.2 0.42 10.1 0.1 2.3 2 2 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EPA04860.1 - 0.079 11.7 1.0 2.7 6.6 0.1 2.5 3 0 0 3 3 3 0 HI0933-like protein GFO_IDH_MocA PF01408.22 EPA04861.1 - 9.2e-26 91.0 0.0 1.6e-25 90.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EPA04861.1 - 1.5e-06 28.2 0.1 2.9e-06 27.3 0.1 1.5 1 1 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 EPA04861.1 - 0.034 14.8 0.1 0.59 10.8 0.0 2.2 2 0 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain DUF3228 PF11539.8 EPA04861.1 - 0.035 13.6 0.3 0.082 12.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3228) Semialdhyde_dh PF01118.24 EPA04861.1 - 0.081 13.4 0.3 0.27 11.7 0.0 2.1 3 0 0 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain DUF4352 PF11611.8 EPA04862.1 - 0.015 15.6 0.2 0.022 15.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4352) Sar8_2 PF03058.14 EPA04863.1 - 0.07 13.7 0.0 0.1 13.1 0.0 1.3 1 0 0 1 1 1 0 Sar8.2 family DciA PF05258.12 EPA04863.1 - 0.21 12.0 0.0 0.31 11.4 0.0 1.3 1 0 0 1 1 1 0 Dna[CI] antecedent, DciA DNA_gyraseA_C PF03989.13 EPA04865.1 - 0.017 14.6 0.5 3.3 7.3 0.0 2.2 2 0 0 2 2 2 0 DNA gyrase C-terminal domain, beta-propeller DUF3185 PF11381.8 EPA04865.1 - 0.094 12.7 2.1 0.15 12.1 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3185) DUF4179 PF13786.6 EPA04865.1 - 0.18 12.3 2.6 0.24 11.9 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) Thioredoxin_4 PF13462.6 EPA04866.1 - 3.1e-34 118.5 0.0 3.8e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 EPA04866.1 - 4.2e-12 46.2 0.0 8.1e-11 42.0 0.0 2.1 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 EPA04866.1 - 6.9e-09 36.1 0.0 1e-08 35.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_5 PF13743.6 EPA04866.1 - 0.0069 16.1 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EPA04866.1 - 0.029 14.7 0.1 8.3 6.8 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin-like Peptidase_S24 PF00717.23 EPA04868.1 - 2.1e-09 37.2 0.4 3.8e-09 36.4 0.4 1.4 1 0 0 1 1 1 1 Peptidase S24-like Pho88 PF10032.9 EPA04868.1 - 0.014 14.7 1.3 0.02 14.1 0.6 1.7 1 1 0 1 1 1 0 Phosphate transport (Pho88) DUF4282 PF14110.6 EPA04868.1 - 0.15 12.8 0.2 0.15 12.8 0.2 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4282) DUF1129 PF06570.11 EPA04868.1 - 0.15 11.5 11.4 0.81 9.1 0.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1129) DUF202 PF02656.15 EPA04868.1 - 0.17 12.3 5.6 5.2 7.6 1.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF202) TctB PF07331.11 EPA04868.1 - 2.2 8.6 13.3 4.1 7.7 4.0 2.9 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter TctB family EamA PF00892.20 EPA04869.1 - 2.2e-13 50.6 9.3 2.5e-13 50.4 9.3 1.0 1 0 0 1 1 1 1 EamA-like transporter family Insulin_TMD PF17870.1 EPA04869.1 - 0.034 14.2 0.7 3.2 7.9 0.1 2.4 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Cation_ATPase_C PF00689.21 EPA04869.1 - 0.042 13.5 5.3 0.053 13.2 5.3 1.2 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus DUF3671 PF12420.8 EPA04869.1 - 4.5 7.4 9.7 0.38 10.8 2.9 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF3293 PF11697.8 EPA04871.1 - 0.058 13.9 0.1 0.067 13.7 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3293) zf-C2H2_2 PF12756.7 EPA04873.1 - 0.0037 17.6 0.1 0.0041 17.4 0.1 1.0 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) DUF629 PF04780.12 EPA04873.1 - 0.019 13.5 0.0 0.019 13.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) zf-C2H2_4 PF13894.6 EPA04873.1 - 0.022 15.6 0.4 0.029 15.2 0.4 1.2 1 0 0 1 1 1 0 C2H2-type zinc finger zf-Di19 PF05605.12 EPA04873.1 - 0.031 14.6 0.1 0.037 14.3 0.1 1.1 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding EF-hand_8 PF13833.6 EPA04874.1 - 0.089 12.7 0.3 0.097 12.5 0.3 1.0 1 0 0 1 1 1 0 EF-hand domain pair ABC_tran PF00005.27 EPA04875.1 - 3.7e-19 69.6 0.0 5.7e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter RLI PF04068.15 EPA04875.1 - 2e-11 43.5 3.4 2e-11 43.5 3.4 2.0 2 0 0 2 2 2 1 Possible Fer4-like domain in RNase L inhibitor, RLI Fer4 PF00037.27 EPA04875.1 - 9.5e-09 34.7 13.4 1.4e-08 34.1 5.3 2.8 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_6 PF12837.7 EPA04875.1 - 1.6e-07 31.1 16.5 1.1e-06 28.5 4.5 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EPA04875.1 - 2.1e-06 27.5 2.2 2.1e-06 27.5 2.2 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_10 PF13237.6 EPA04875.1 - 6e-06 26.3 12.2 4.9e-05 23.4 1.3 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 EPA04875.1 - 1e-05 25.6 12.7 1.8e-05 24.8 12.7 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain SMC_N PF02463.19 EPA04875.1 - 8.8e-05 22.0 1.7 0.0012 18.3 1.7 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Fer4_7 PF12838.7 EPA04875.1 - 0.0001 22.8 11.6 0.00033 21.2 11.9 1.7 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EPA04875.1 - 0.0014 19.5 10.8 0.0043 18.0 1.6 2.6 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 EPA04875.1 - 0.0032 17.6 1.9 0.0032 17.6 1.9 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain RsgA_GTPase PF03193.16 EPA04875.1 - 0.0041 17.0 0.0 0.0089 15.9 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase Fer4_4 PF12800.7 EPA04875.1 - 0.012 16.0 2.6 0.012 16.0 2.6 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_3 PF12798.7 EPA04875.1 - 0.021 15.7 15.4 0.045 14.7 5.0 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain RE_XcyI PF09571.10 EPA04875.1 - 0.027 13.7 0.1 0.041 13.1 0.1 1.2 1 0 0 1 1 1 0 XcyI restriction endonuclease Rad17 PF03215.15 EPA04875.1 - 0.036 14.0 0.0 0.083 12.8 0.0 1.6 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_16 PF13191.6 EPA04875.1 - 0.054 13.9 0.0 0.1 12.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Fer4_17 PF13534.6 EPA04875.1 - 0.078 13.5 1.2 0.078 13.5 1.2 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain AAA_29 PF13555.6 EPA04875.1 - 0.084 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 EPA04875.1 - 0.086 12.6 4.0 1.6 8.5 1.3 2.4 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EPA04875.1 - 0.092 12.8 1.5 0.22 11.6 1.5 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase MeaB PF03308.16 EPA04875.1 - 0.16 10.9 0.0 0.34 9.9 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_8 PF13183.6 EPA04875.1 - 0.88 10.1 8.9 0.28 11.6 1.7 1.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_15 PF13459.6 EPA04875.1 - 7.6 7.3 11.6 1.9 9.3 3.7 2.8 1 1 0 1 1 1 0 4Fe-4S single cluster domain DUF5638 PF18688.1 EPA04876.1 - 0.073 13.4 0.0 0.079 13.3 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5638) DUF5615 PF18480.1 EPA04877.1 - 2.8e-07 30.2 0.1 4.1e-07 29.7 0.1 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF5615) Mut7-C PF01927.16 EPA04877.1 - 0.0072 16.4 0.0 0.0074 16.4 0.0 1.1 1 0 0 1 1 1 1 Mut7-C RNAse domain Penicillinase_R PF03965.16 EPA04879.1 - 0.00096 19.5 0.2 0.0017 18.7 0.1 1.5 2 0 0 2 2 2 1 Penicillinase repressor AAA_assoc_C PF09821.9 EPA04879.1 - 0.045 14.3 0.1 0.15 12.6 0.0 1.8 1 1 1 2 2 2 0 C-terminal AAA-associated domain MitMem_reg PF13012.6 EPA04883.1 - 0.0091 16.4 0.9 0.02 15.3 0.8 1.5 1 1 0 1 1 1 1 Maintenance of mitochondrial structure and function SepSecS PF05889.13 EPA04883.1 - 0.11 11.1 2.7 0.22 10.2 0.8 2.1 1 1 1 2 2 2 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Mt_ATP-synt_D PF05873.12 EPA04883.1 - 0.25 11.2 2.8 0.35 10.7 2.7 1.4 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Ycf66_N PF07444.11 EPA04884.1 - 9.1e-06 25.7 0.3 0.0036 17.4 0.0 2.1 2 0 0 2 2 2 2 Ycf66 protein N-terminus Oxidored_q3 PF00499.20 EPA04884.1 - 0.0019 18.0 0.8 0.0021 17.8 0.8 1.0 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Cytochrom_B561 PF03188.16 EPA04884.1 - 0.042 14.0 0.7 0.055 13.6 0.7 1.3 1 0 0 1 1 1 0 Eukaryotic cytochrome b561 FixQ PF05545.11 EPA04884.1 - 0.046 13.7 0.0 0.046 13.7 0.0 2.1 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ RPA_interact_C PF14768.6 EPA04886.1 - 0.026 15.1 0.7 4.1 8.0 0.0 2.1 2 0 0 2 2 2 0 Replication protein A interacting C-terminal TF_Zn_Ribbon PF08271.12 EPA04886.1 - 0.12 11.9 2.0 0.18 11.4 2.0 1.4 1 1 0 1 1 1 0 TFIIB zinc-binding SWIB PF02201.18 EPA04887.1 - 0.018 14.9 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 SWIB/MDM2 domain ADH_zinc_N PF00107.26 EPA04888.1 - 7.2e-28 97.2 0.1 1.3e-27 96.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EPA04888.1 - 1.5e-21 76.3 0.0 2.6e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EPA04888.1 - 1e-17 65.5 0.1 1.7e-17 64.7 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ACP_syn_III_C PF08541.10 EPA04888.1 - 0.099 12.8 0.1 0.34 11.1 0.1 1.9 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Glyco_hydro_35 PF01301.19 EPA04889.1 - 0.0067 16.1 0.1 0.033 13.8 0.1 2.1 3 0 0 3 3 3 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 EPA04889.1 - 0.023 14.1 0.1 0.059 12.7 0.0 1.7 2 0 0 2 2 2 0 Beta-galactosidase Suv3_C_1 PF18147.1 EPA04889.1 - 0.22 11.4 0.0 0.35 10.8 0.0 1.3 1 0 0 1 1 1 0 Suv3 C-terminal domain 1 Amidohydro_1 PF01979.20 EPA04891.1 - 7.5e-42 143.9 0.7 8.8e-42 143.6 0.7 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EPA04891.1 - 1.2e-15 58.0 0.0 1.8e-09 37.6 0.0 2.3 2 1 1 3 3 3 2 Amidohydrolase family TPR_1 PF00515.28 EPA04892.1 - 6.5e-24 82.7 7.6 2e-07 30.6 0.1 5.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EPA04892.1 - 2.3e-17 61.6 1.0 0.00054 19.9 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EPA04892.1 - 5e-17 62.0 0.6 7.1e-06 26.2 0.1 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EPA04892.1 - 1.4e-14 52.9 9.2 6.2e-05 22.9 0.1 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 EPA04892.1 - 5.5e-11 41.7 0.3 0.01 15.8 0.0 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 EPA04892.1 - 8.9e-10 38.1 0.1 0.01 15.7 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EPA04892.1 - 3.2e-08 33.7 0.0 1.9 9.5 0.0 5.5 1 1 4 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 EPA04892.1 - 6.5e-08 33.0 0.3 0.0076 16.7 0.1 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EPA04892.1 - 1e-07 32.1 7.5 0.00044 20.4 0.7 2.4 2 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EPA04892.1 - 5e-07 29.9 0.2 4.4 8.1 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EPA04892.1 - 7.2e-07 29.7 0.0 0.0065 17.1 0.0 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EPA04892.1 - 1e-06 28.8 0.0 0.16 12.1 0.0 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EPA04892.1 - 1e-06 28.7 4.5 0.13 12.7 0.2 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EPA04892.1 - 7.8e-06 25.5 2.0 0.0029 17.3 0.5 3.9 3 1 1 4 4 4 1 TPR repeat SRP_TPR_like PF17004.5 EPA04892.1 - 1e-05 25.5 7.4 0.0031 17.5 0.4 3.2 1 1 2 3 3 3 3 Putative TPR-like repeat Fis1_TPR_C PF14853.6 EPA04892.1 - 4.8e-05 23.4 4.8 4.9 7.3 0.1 4.5 5 0 0 5 5 5 3 Fis1 C-terminal tetratricopeptide repeat Phage_Treg PF04761.12 EPA04892.1 - 0.00019 21.4 0.1 0.26 11.4 0.0 3.0 3 0 0 3 3 3 1 Lactococcus bacteriophage putative transcription regulator NARP1 PF12569.8 EPA04892.1 - 0.00055 19.0 1.5 0.0016 17.4 0.3 2.0 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 DUF3856 PF12968.7 EPA04892.1 - 0.0017 18.5 0.1 3.6 7.7 0.0 4.1 1 1 3 4 4 4 1 Domain of Unknown Function (DUF3856) Alkyl_sulf_dimr PF14863.6 EPA04892.1 - 0.0024 18.3 0.5 1.7 9.1 0.1 2.6 2 1 1 3 3 3 1 Alkyl sulfatase dimerisation MIT PF04212.18 EPA04892.1 - 0.0044 17.1 3.5 0.014 15.4 0.5 3.0 4 0 0 4 4 3 1 MIT (microtubule interacting and transport) domain TPR_15 PF13429.6 EPA04892.1 - 0.0065 15.7 0.1 0.11 11.7 0.3 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat DUF4919 PF16266.5 EPA04892.1 - 0.0073 16.3 2.1 0.065 13.2 0.1 2.5 1 1 2 3 3 3 1 Domain of unknown function (DUF4919) UvsY PF11056.8 EPA04892.1 - 0.69 10.3 6.2 3.1 8.1 0.1 3.2 2 2 0 3 3 3 0 Recombination, repair and ssDNA binding protein UvsY VEG PF06257.11 EPA04893.1 - 0.059 13.4 0.3 0.094 12.8 0.2 1.4 1 1 0 1 1 1 0 Biofilm formation stimulator VEG RibD_C PF01872.17 EPA04894.1 - 7.3e-18 65.1 0.0 7.9e-18 65.0 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain dsDNA_bind PF01984.20 EPA04895.1 - 1.7e-23 83.0 2.2 1.8e-23 82.9 2.2 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain DMRL_synthase PF00885.19 EPA04896.1 - 3e-26 92.0 0.2 3.4e-26 91.7 0.2 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Metallophos_3 PF14582.6 EPA04896.1 - 0.075 12.3 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily Sua5_yciO_yrdC PF01300.18 EPA04897.1 - 1.7e-59 200.3 0.0 2.8e-59 199.6 0.0 1.3 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EPA04897.1 - 4.9e-29 101.6 0.0 7.5e-29 101.0 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding IL2 PF00715.17 EPA04897.1 - 0.1 12.5 0.6 0.22 11.5 0.2 1.7 2 0 0 2 2 2 0 Interleukin 2 Oxidored_q6 PF01058.22 EPA04897.1 - 0.16 11.8 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase, 20 Kd subunit EF-hand_1 PF00036.32 EPA04897.1 - 0.24 11.0 2.1 0.62 9.7 0.0 2.8 4 0 0 4 4 4 0 EF hand RibD_C PF01872.17 EPA04898.1 - 4.2e-22 78.9 0.0 4.6e-22 78.8 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain Rpr2 PF04032.16 EPA04899.1 - 1.7e-14 53.8 1.6 2.5e-14 53.3 1.6 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-Sec23_Sec24 PF04810.15 EPA04899.1 - 0.023 14.7 2.4 0.085 12.9 2.4 1.9 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger DUF3268 PF11672.8 EPA04899.1 - 0.043 14.2 0.1 0.059 13.7 0.1 1.2 1 0 0 1 1 1 0 zinc-finger-containing domain Pyr_redox_2 PF07992.14 EPA04900.1 - 6.2e-34 117.6 0.0 7.1e-34 117.4 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EPA04900.1 - 9.2e-08 32.5 0.9 0.0023 18.5 1.2 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EPA04900.1 - 2.1e-05 23.9 0.0 0.046 12.9 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EPA04900.1 - 0.0039 17.2 0.1 0.62 10.0 0.0 3.1 3 0 0 3 3 3 1 FAD-NAD(P)-binding Actin_micro PF17003.5 EPA04900.1 - 0.0077 15.5 5.1 0.016 14.4 5.1 1.8 1 1 0 1 1 1 1 Putative actin-like family zf-C2H2_4 PF13894.6 EPA04900.1 - 0.21 12.5 0.8 0.48 11.4 0.8 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger DHBP_synthase PF00926.19 EPA04901.1 - 3.5e-60 202.8 0.0 4e-60 202.7 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase PAF-AH_p_II PF03403.13 EPA04901.1 - 0.06 11.8 0.0 0.083 11.4 0.0 1.3 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Hemerythrin PF01814.23 EPA04902.1 - 3e-13 50.5 0.5 2e-12 47.9 0.1 2.3 2 1 0 2 2 2 1 Hemerythrin HHE cation binding domain Prominin PF05478.11 EPA04902.1 - 0.0021 16.1 0.9 0.0032 15.5 0.9 1.2 1 0 0 1 1 1 1 Prominin UPF0113_N PF17833.1 EPA04902.1 - 0.015 15.9 0.2 0.035 14.7 0.2 1.6 1 0 0 1 1 1 0 UPF0113 Pre-PUA domain DUF1043 PF06295.12 EPA04902.1 - 0.016 15.2 2.3 0.065 13.2 1.5 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1043) EDR1 PF14381.6 EPA04902.1 - 0.018 14.8 0.2 0.025 14.3 0.2 1.3 1 0 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 IZUMO PF15005.6 EPA04902.1 - 0.025 15.1 2.3 0.03 14.8 1.1 1.7 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Spore_YtfJ PF09579.10 EPA04902.1 - 0.042 14.0 0.0 0.1 12.8 0.0 1.6 2 0 0 2 2 2 0 Sporulation protein YtfJ (Spore_YtfJ) Methyltransf_4 PF02390.17 EPA04902.1 - 0.11 11.9 0.9 0.21 11.1 0.9 1.5 1 0 0 1 1 1 0 Putative methyltransferase EMG1 PF03587.14 EPA04903.1 - 2.2e-39 135.1 0.5 2.5e-39 135.0 0.5 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Glyco_transf_4 PF13439.6 EPA04903.1 - 0.14 12.1 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Response_reg PF00072.24 EPA04904.1 - 8.6e-21 74.2 0.1 9.6e-21 74.1 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain Lum_binding PF00677.17 EPA04905.1 - 4.2e-45 151.6 4.8 1.1e-23 83.0 0.1 2.0 2 0 0 2 2 2 2 Lumazine binding domain Aldedh PF00171.22 EPA04906.1 - 3.2e-122 408.3 0.4 3.8e-122 408.1 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ribosomal_S19e PF01090.19 EPA04908.1 - 5.8e-48 162.1 0.0 6.5e-48 161.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e RuvB_C PF05491.13 EPA04908.1 - 0.12 12.2 0.0 3.3 7.6 0.0 2.3 2 0 0 2 2 2 0 RuvB C-terminal winged helix domain DUF2007 PF09413.10 EPA04908.1 - 0.12 12.5 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein ArsC PF03960.15 EPA04908.1 - 0.14 12.2 0.0 0.32 11.1 0.0 1.9 1 1 0 1 1 1 0 ArsC family GCH_III PF05165.12 EPA04909.1 - 3.6e-51 173.8 0.0 5e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase III mCpol PF18182.1 EPA04909.1 - 1.8e-07 31.4 1.6 0.00092 19.5 0.2 2.2 2 0 0 2 2 2 2 minimal CRISPR polymerase domain Guanylate_cyc PF00211.20 EPA04909.1 - 0.0003 20.5 0.2 0.00072 19.2 0.1 1.8 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain GGDEF_2 PF17853.1 EPA04909.1 - 0.0021 18.3 0.0 1 9.6 0.0 2.1 2 0 0 2 2 2 2 GGDEF-like domain NOG1 PF06858.14 EPA04909.1 - 0.024 14.4 0.6 0.17 11.7 0.1 2.5 3 0 0 3 3 3 0 Nucleolar GTP-binding protein 1 (NOG1) DUF3908 PF13048.6 EPA04909.1 - 0.043 14.1 2.2 0.24 11.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3908) F420H2_quin_red PF04075.14 EPA04909.1 - 0.068 13.3 0.0 0.87 9.7 0.0 2.1 2 0 0 2 2 2 0 F420H(2)-dependent quinone reductase HpcH_HpaI PF03328.14 EPA04910.1 - 3.2e-44 150.7 0.0 3.6e-44 150.5 0.0 1.0 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EPA04910.1 - 8.4e-13 48.2 0.0 4.4e-07 29.4 0.0 2.1 1 1 1 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold PK PF00224.21 EPA04910.1 - 0.032 13.1 0.1 0.042 12.7 0.1 1.1 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain RDD PF06271.12 EPA04912.1 - 4e-19 69.2 1.4 4.9e-19 68.9 1.4 1.1 1 0 0 1 1 1 1 RDD family TctB PF07331.11 EPA04912.1 - 0.049 13.9 0.3 0.065 13.5 0.3 1.2 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Calycin_like PF13944.6 EPA04913.1 - 0.01 16.2 1.8 0.021 15.1 1.8 1.6 1 1 0 1 1 1 0 Calycin-like beta-barrel domain PepSY_TM_like_2 PF16357.5 EPA04914.1 - 0.13 12.2 0.0 0.15 12.1 0.0 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like Methyltransf_11 PF08241.12 EPA04915.1 - 1.3e-10 41.8 0.0 2.2e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA04915.1 - 4.3e-05 24.1 0.0 6.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA04915.1 - 0.0003 20.6 0.0 0.0005 19.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA04915.1 - 0.0035 18.0 0.0 0.006 17.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EPA04915.1 - 0.0045 16.9 0.0 0.0099 15.7 0.0 1.7 1 1 0 1 1 1 1 Hypothetical methyltransferase SAICAR_synt PF01259.18 EPA04916.1 - 3.9e-71 239.6 0.2 4.7e-71 239.3 0.2 1.1 1 0 0 1 1 1 1 SAICAR synthetase DUF2299 PF10061.9 EPA04917.1 - 2.3e-19 69.5 0.5 2.8e-19 69.2 0.5 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2299) HAD_SAK_2 PF18143.1 EPA04917.1 - 0.031 14.6 0.1 0.048 14.0 0.1 1.3 1 0 0 1 1 1 0 HAD domain in Swiss Army Knife RNA repair proteins Ribosomal_S14 PF00253.21 EPA04919.1 - 2.5e-08 33.6 2.7 3.3e-08 33.2 2.7 1.2 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e zf-FPG_IleRS PF06827.14 EPA04919.1 - 0.058 13.3 3.1 0.12 12.2 3.0 1.7 1 1 1 2 2 2 0 Zinc finger found in FPG and IleRS HTH_20 PF12840.7 EPA04920.1 - 1.9e-08 34.2 0.0 3.6e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 EPA04920.1 - 3.1e-07 30.2 0.4 2.4e-06 27.3 0.4 2.2 1 1 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_12 PF08461.10 EPA04920.1 - 1.6e-06 27.9 0.3 3.5e-06 26.9 0.3 1.6 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain FUR PF01475.19 EPA04920.1 - 0.00012 22.2 0.3 0.00027 21.0 0.3 1.7 1 1 0 1 1 1 1 Ferric uptake regulator family HU-DNA_bdg PF14848.6 EPA04920.1 - 0.0073 16.3 1.0 0.023 14.7 0.4 1.9 1 1 1 2 2 2 1 DNA-binding domain Replic_Relax PF13814.6 EPA04920.1 - 0.014 15.4 0.1 0.035 14.2 0.0 1.7 2 0 0 2 2 2 0 Replication-relaxation Type2_restr_D3 PF16902.5 EPA04920.1 - 0.026 14.5 0.3 0.059 13.3 0.3 1.6 1 0 0 1 1 1 0 Type-2 restriction enzyme D3 domain HTH_11 PF08279.12 EPA04920.1 - 0.028 14.4 0.8 0.35 10.9 0.8 2.3 1 1 0 1 1 1 0 HTH domain Polyketide_cyc2 PF10604.9 EPA04921.1 - 2.1e-06 28.0 0.0 2.3e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 EPA04921.1 - 0.0022 18.2 0.0 0.0027 17.9 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF4352 PF11611.8 EPA04923.1 - 3.6e-10 40.2 1.9 4.6e-10 39.9 1.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4352) Aegerolysin PF06355.13 EPA04923.1 - 0.014 15.4 0.9 0.052 13.6 0.1 2.1 3 0 0 3 3 3 0 Aegerolysin DUF5305 PF17231.2 EPA04923.1 - 4.3 6.7 7.6 0.52 9.7 2.9 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5305) Putative_PNPOx PF01243.20 EPA04924.1 - 9.1e-16 57.8 0.0 1.3e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 EPA04924.1 - 0.053 13.5 0.0 0.084 12.9 0.0 1.3 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase RcnB PF11776.8 EPA04924.1 - 0.09 12.8 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Nickel/cobalt transporter regulator PurS PF02700.14 EPA04925.1 - 4.8e-18 65.1 0.8 5.3e-18 65.0 0.8 1.0 1 0 0 1 1 1 1 Phosphoribosylformylglycinamidine (FGAM) synthase AIRS_C PF02769.22 EPA04926.1 - 1.2e-49 168.4 0.2 5.7e-29 101.3 0.3 2.2 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.24 EPA04926.1 - 6.4e-38 129.3 0.0 2.6e-19 69.7 0.2 2.7 2 0 0 2 2 2 2 AIR synthase related protein, N-terminal domain FGAR-AT_linker PF18072.1 EPA04926.1 - 5.6e-11 42.8 0.1 1.6e-10 41.3 0.1 1.9 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain T_Ag_DNA_bind PF02217.16 EPA04926.1 - 0.036 14.7 2.1 0.04 14.5 0.2 2.0 2 0 0 2 2 2 0 Origin of replication binding protein DUF5300 PF17224.3 EPA04927.1 - 0.00077 19.7 0.0 0.0011 19.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5300) TatC PF00902.18 EPA04928.1 - 1.2e-50 172.3 15.9 1.4e-50 172.0 15.9 1.1 1 0 0 1 1 1 1 Sec-independent protein translocase protein (TatC) Ribosomal_L6 PF00347.23 EPA04929.1 - 6.2e-09 36.4 4.8 0.00046 20.8 0.2 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 BON PF04972.17 EPA04929.1 - 0.057 13.7 3.8 13 6.1 0.1 3.5 4 1 0 4 4 4 0 BON domain RL10P_insert PF17777.1 EPA04929.1 - 0.11 12.5 0.3 0.47 10.5 0.3 2.1 1 1 0 1 1 1 0 Insertion domain in 60S ribosomal protein L10P Gram_pos_anchor PF00746.21 EPA04930.1 - 0.057 13.4 0.1 0.066 13.2 0.1 1.2 1 0 0 1 1 1 0 LPXTG cell wall anchor motif GATase_6 PF13522.6 EPA04931.1 - 3.4e-13 49.9 0.0 8.4e-13 48.7 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EPA04931.1 - 1.4e-12 47.6 0.0 2.4e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EPA04931.1 - 6.8e-10 38.7 0.0 1.2e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EPA04931.1 - 1.2e-05 24.3 0.0 2.5e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.21 EPA04931.1 - 0.00012 21.0 0.0 0.14 10.9 0.0 3.0 3 0 0 3 3 3 2 Glutamine amidotransferases class-II DUF3919 PF13057.6 EPA04931.1 - 0.07 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) Pribosyltran_N PF13793.6 EPA04931.1 - 0.097 12.6 0.1 0.25 11.3 0.1 1.7 1 0 0 1 1 1 0 N-terminal domain of ribose phosphate pyrophosphokinase Dip PF17679.1 EPA04931.1 - 0.11 12.1 0.1 0.37 10.4 0.0 1.8 3 0 0 3 3 3 0 gp37/Dip protein RQC PF09382.10 EPA04931.1 - 0.14 11.9 0.0 0.51 10.1 0.0 1.9 2 0 0 2 2 2 0 RQC domain NTP_transf_9 PF04248.12 EPA04932.1 - 5.3e-32 109.6 0.6 5.9e-32 109.4 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF427) DUF1246 PF06849.12 EPA04933.1 - 1.4e-20 73.5 0.0 1.8e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1246) DUF4860 PF16152.5 EPA04933.1 - 0.08 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4860) SIMPL PF04402.14 EPA04934.1 - 1.4e-43 149.7 1.3 1.7e-43 149.4 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) GATase_5 PF13507.6 EPA04935.1 - 1.5e-05 24.2 0.0 1.6e-05 24.2 0.0 1.0 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Molybdopterin_N PF18364.1 EPA04935.1 - 0.12 12.4 0.1 1.3 9.1 0.0 2.0 1 1 1 2 2 2 0 Molybdopterin oxidoreductase N-terminal domain GATase_5 PF13507.6 EPA04937.1 - 9.1e-26 90.5 0.0 1.2e-25 90.1 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase_3 PF07685.14 EPA04937.1 - 1.8e-08 34.2 0.0 3.1e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 EPA04937.1 - 2.8e-08 33.8 0.0 3.4e-08 33.5 0.0 1.3 1 1 0 1 1 1 1 Glutamine amidotransferase class-I DJ-1_PfpI PF01965.24 EPA04937.1 - 4.3e-08 33.1 0.0 6e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family Peptidase_C26 PF07722.13 EPA04937.1 - 0.00093 19.0 0.2 0.002 18.0 0.2 1.6 1 1 0 1 1 1 1 Peptidase C26 SNO PF01174.19 EPA04937.1 - 0.066 13.0 0.0 0.098 12.5 0.0 1.2 1 0 0 1 1 1 0 SNO glutamine amidotransferase family Ribosomal_S8 PF00410.19 EPA04938.1 - 6.6e-21 74.6 0.0 7.7e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 DUF1297 PF06973.12 EPA04939.1 - 5.3e-47 159.8 0.0 5.7e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) Ribosomal_L5_C PF00673.21 EPA04941.1 - 5e-21 74.7 0.0 7.9e-21 74.1 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EPA04941.1 - 1.1e-11 44.9 0.1 1.8e-11 44.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 MttA_Hcf106 PF02416.16 EPA04942.1 - 2.6e-11 42.7 1.5 3.3e-11 42.3 1.5 1.2 1 0 0 1 1 1 1 mttA/Hcf106 family Pentapeptide PF00805.22 EPA04945.1 - 1.3e-33 114.2 9.8 7.3e-11 41.5 0.1 4.4 1 1 2 4 4 4 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EPA04945.1 - 1.6e-15 57.0 0.0 2.1e-08 34.2 0.0 2.5 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EPA04945.1 - 6.2e-13 48.7 0.7 0.00011 22.3 0.3 4.1 1 1 3 4 4 4 3 Pentapeptide repeats (9 copies) Baculo_11_kDa PF06143.11 EPA04946.1 - 0.00084 18.9 0.6 0.00088 18.8 0.6 1.1 1 0 0 1 1 1 1 Baculovirus 11 kDa family DUF4870 PF09685.10 EPA04946.1 - 0.0045 17.1 0.6 0.0045 17.1 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4870) OSTMP1 PF09777.9 EPA04946.1 - 0.0085 15.5 0.3 0.0085 15.5 0.3 1.0 1 0 0 1 1 1 1 Osteopetrosis-associated transmembrane protein 1 precursor TMEM171 PF15471.6 EPA04946.1 - 0.018 14.0 0.2 0.018 14.0 0.2 1.0 1 0 0 1 1 1 0 Transmembrane protein family 171 Arteri_Gl PF00951.18 EPA04946.1 - 0.035 13.9 0.2 0.039 13.8 0.2 1.0 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein DUF2367 PF10164.9 EPA04946.1 - 0.12 12.9 0.6 0.13 12.7 0.6 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) Flavoprotein PF02441.19 EPA04947.1 - 3.8e-30 104.7 0.3 4.6e-30 104.5 0.3 1.0 1 0 0 1 1 1 1 Flavoprotein 5TM-5TMR_LYT PF07694.12 EPA04949.1 - 0.0031 17.1 0.1 0.0035 16.9 0.1 1.1 1 0 0 1 1 1 1 5TMR of 5TMR-LYT RseC_MucC PF04246.12 EPA04949.1 - 0.017 15.1 0.1 0.02 14.9 0.1 1.1 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC DUF1129 PF06570.11 EPA04949.1 - 0.026 14.0 0.1 0.027 14.0 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Cyt_bd_oxida_I PF01654.17 EPA04949.1 - 0.072 11.7 0.1 0.079 11.6 0.1 1.0 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit I DUF2407_C PF13373.6 EPA04949.1 - 0.17 12.1 0.2 0.22 11.7 0.2 1.2 1 0 0 1 1 1 0 DUF2407 C-terminal domain Vps39_1 PF10366.9 EPA04950.1 - 0.054 13.8 0.1 0.054 13.8 0.1 1.0 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 AsnC_trans_reg PF01037.21 EPA04951.1 - 4.7e-09 36.1 0.5 5.2e-09 36.0 0.5 1.1 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain PRANC PF09372.10 EPA04951.1 - 0.0019 18.5 0.1 0.0021 18.3 0.1 1.0 1 0 0 1 1 1 1 PRANC domain Terminase_2 PF03592.16 EPA04951.1 - 0.044 14.2 1.1 0.05 14.1 1.1 1.1 1 0 0 1 1 1 0 Terminase small subunit HTH_5 PF01022.20 EPA04952.1 - 1.5e-09 37.5 0.0 4.2e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 EPA04952.1 - 2.7e-08 33.2 0.0 5.6e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 EPA04952.1 - 2.7e-07 30.6 0.0 4.6e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_11 PF08279.12 EPA04952.1 - 0.0014 18.5 0.2 0.0036 17.2 0.2 1.6 1 0 0 1 1 1 1 HTH domain MarR_2 PF12802.7 EPA04952.1 - 0.0042 16.9 0.0 0.0072 16.2 0.0 1.4 1 0 0 1 1 1 1 MarR family RepL PF05732.11 EPA04952.1 - 0.0062 16.0 0.1 0.013 15.0 0.1 1.5 1 0 0 1 1 1 1 Firmicute plasmid replication protein (RepL) HTH_40 PF14493.6 EPA04952.1 - 0.0077 16.7 0.1 0.023 15.1 0.1 1.9 1 1 0 1 1 1 1 Helix-turn-helix domain TFIIE_alpha PF02002.17 EPA04952.1 - 0.022 14.6 0.2 0.041 13.8 0.2 1.4 1 0 0 1 1 1 0 TFIIE alpha subunit Rrf2 PF02082.20 EPA04952.1 - 0.033 14.5 0.1 0.082 13.3 0.1 1.7 1 0 0 1 1 1 0 Transcriptional regulator TrmB PF01978.19 EPA04952.1 - 0.039 13.8 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_CodY PF08222.11 EPA04952.1 - 0.074 12.6 0.0 0.26 10.9 0.0 1.9 2 0 0 2 2 2 0 CodY helix-turn-helix domain GrpE PF01025.19 EPA04954.1 - 5.7e-36 123.7 3.7 6.4e-36 123.5 3.7 1.0 1 0 0 1 1 1 1 GrpE EST1_DNA_bind PF10373.9 EPA04954.1 - 0.0068 15.9 0.5 0.0077 15.7 0.5 1.1 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain DUF3437 PF11919.8 EPA04954.1 - 0.18 11.7 0.2 0.45 10.5 0.2 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF3437) DUF334 PF03904.13 EPA04954.1 - 0.4 10.2 4.9 0.6 9.6 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF334) HSP70 PF00012.20 EPA04955.1 - 2.8e-21 75.4 0.1 3e-21 75.3 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein Aminotran_5 PF00266.19 EPA04956.1 - 5.3e-151 502.8 0.7 6.1e-151 502.6 0.7 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EPA04956.1 - 5.4e-07 29.1 0.2 4.6e-06 26.0 0.1 2.0 2 0 0 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EPA04956.1 - 0.0001 21.0 0.0 0.00025 19.7 0.0 1.6 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EPA04956.1 - 0.00015 21.2 0.1 0.00042 19.7 0.1 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.19 EPA04956.1 - 0.039 12.7 0.0 0.065 11.9 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain Phage_Gp15 PF06854.11 EPA04957.1 - 0.033 14.2 0.1 0.037 14.0 0.1 1.0 1 0 0 1 1 1 0 Bacteriophage Gp15 protein TPR_1 PF00515.28 EPA04958.1 - 1.3e-16 59.6 1.0 4e-07 29.6 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EPA04958.1 - 5e-15 54.4 1.0 4e-08 32.8 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EPA04958.1 - 5.9e-15 54.1 0.4 7.2e-07 28.9 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EPA04958.1 - 6.3e-11 42.6 0.1 1.3e-07 32.0 0.0 2.1 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EPA04958.1 - 2.9e-10 39.8 0.3 0.0051 17.1 0.1 3.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EPA04958.1 - 7.4e-09 35.7 0.0 0.0084 16.9 0.0 2.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EPA04958.1 - 2.4e-08 33.4 0.0 0.013 15.5 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EPA04958.1 - 1.5e-07 31.6 0.1 2.6e-07 30.8 0.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EPA04958.1 - 1.9e-07 30.6 0.2 0.016 14.9 0.0 3.1 3 0 0 3 3 3 2 TPR repeat TPR_12 PF13424.6 EPA04958.1 - 7.3e-06 26.2 0.0 0.00015 21.9 0.0 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EPA04958.1 - 5.3e-05 23.6 0.1 0.6 10.9 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EPA04958.1 - 7.6e-05 22.7 1.7 0.029 14.5 0.1 3.2 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 EPA04958.1 - 0.00011 21.5 0.0 0.00017 20.9 0.0 1.3 1 1 0 1 1 1 1 Tetratricopeptide repeat ChAPs PF09295.10 EPA04958.1 - 0.00019 20.5 0.1 0.00023 20.3 0.1 1.0 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) NARP1 PF12569.8 EPA04958.1 - 0.0069 15.3 0.4 0.13 11.2 0.0 1.9 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 TPR_16 PF13432.6 EPA04958.1 - 0.012 16.3 0.0 0.17 12.5 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4919 PF16266.5 EPA04958.1 - 0.018 15.0 0.5 0.072 13.0 0.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4919) TPR_9 PF13371.6 EPA04958.1 - 0.14 12.4 0.0 7.2 6.8 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat Porphobil_deam PF01379.20 EPA04959.1 - 7.1e-34 117.1 0.0 1.1e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EPA04959.1 - 2.5e-11 43.8 0.0 4.4e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Big_9 PF17963.1 EPA04960.1 - 4.7e-14 52.9 53.9 2.7e-09 37.6 2.4 7.6 7 0 0 7 7 7 5 Bacterial Ig domain Cadherin_5 PF17892.1 EPA04960.1 - 5e-06 26.4 22.0 0.022 14.7 0.3 5.6 5 0 0 5 5 5 3 Cadherin-like domain PKD PF00801.20 EPA04960.1 - 3.8e-05 23.5 25.8 2.1 8.3 0.3 8.6 8 2 0 8 8 8 4 PKD domain Cadherin_4 PF17803.1 EPA04960.1 - 0.00045 20.8 5.4 0.00045 20.8 5.4 7.3 6 2 1 7 7 7 3 Bacterial cadherin-like domain Ig_2 PF13895.6 EPA04960.1 - 0.0012 19.1 4.3 0.13 12.6 0.1 4.3 5 0 0 5 5 5 1 Immunoglobulin domain DUF824 PF05688.11 EPA04960.1 - 0.0018 18.1 2.1 1.1 9.1 0.2 4.1 3 0 0 3 3 3 2 Salmonella repeat of unknown function (DUF824) Waikav_capsid_1 PF12264.8 EPA04960.1 - 0.053 13.0 0.6 0.22 11.0 0.6 2.1 1 0 0 1 1 1 0 Waikavirus capsid protein 1 TIG PF01833.24 EPA04960.1 - 4.9 7.3 16.1 1.7 8.8 0.2 5.7 6 2 0 6 6 6 0 IPT/TIG domain TP_methylase PF00590.20 EPA04961.1 - 4.4e-50 170.6 0.0 5e-50 170.4 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases TatC PF00902.18 EPA04962.1 - 0.039 13.8 4.2 0.043 13.6 4.2 1.1 1 0 0 1 1 1 0 Sec-independent protein translocase protein (TatC) TMEM43 PF07787.12 EPA04962.1 - 0.38 10.1 2.1 0.44 9.9 2.1 1.0 1 0 0 1 1 1 0 Transmembrane protein 43 CrgA PF06781.12 EPA04962.1 - 2 8.5 5.5 12 6.0 5.5 1.9 1 1 0 1 1 1 0 Cell division protein CrgA TMEM238 PF15125.6 EPA04962.1 - 2.8 8.2 8.6 6.6 7.0 2.6 2.1 2 0 0 2 2 2 0 TMEM238 protein family DUF2721 PF11026.8 EPA04962.1 - 4.3 7.2 7.3 11 5.9 1.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) HTH_Tnp_Tc5 PF03221.16 EPA04964.1 - 0.011 15.7 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain HEM4 PF02602.15 EPA04965.1 - 2.7e-45 154.5 0.0 3e-45 154.4 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD CTP_transf_like PF01467.26 EPA04965.1 - 0.027 14.7 0.0 0.077 13.2 0.0 1.6 1 1 0 1 1 1 0 Cytidylyltransferase-like PGM_PMM_II PF02879.16 EPA04965.1 - 0.16 12.6 0.0 0.38 11.4 0.0 1.7 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II ABC2_membrane PF01061.24 EPA04967.1 - 6.7e-34 117.1 18.0 6.7e-34 117.1 18.0 1.9 1 1 1 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 EPA04967.1 - 1.1e-14 54.3 28.4 1.3e-14 54.1 28.4 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 EPA04967.1 - 2.3e-05 23.8 20.5 2.3e-05 23.8 20.5 2.1 1 1 0 2 2 2 1 ABC-2 family transporter protein PGK PF00162.19 EPA04968.1 - 3.2e-98 329.2 0.0 3.6e-98 329.0 0.0 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Baculo_E66 PF04850.12 EPA04969.1 - 0.13 11.0 1.1 0.21 10.3 1.1 1.2 1 0 0 1 1 1 0 Baculovirus E66 occlusion-derived virus envelope protein MFS_1 PF07690.16 EPA04970.1 - 1.9e-14 53.4 22.0 8.8e-08 31.4 17.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EPA04970.1 - 0.0009 17.8 6.4 0.0011 17.4 6.4 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector MFS_1_like PF12832.7 EPA04970.1 - 0.0084 15.0 8.8 0.0095 14.8 8.8 1.2 1 0 0 1 1 1 1 MFS_1 like family CrgA PF06781.12 EPA04970.1 - 0.17 12.0 1.7 0.34 11.0 0.0 2.3 3 0 0 3 3 3 0 Cell division protein CrgA PrgI PF12666.7 EPA04970.1 - 9.3 7.0 14.6 1.8 9.3 4.8 3.2 3 1 1 4 4 4 0 PrgI family protein PRC PF05239.16 EPA04971.1 - 0.00025 21.1 0.2 0.00034 20.6 0.2 1.3 1 1 0 1 1 1 1 PRC-barrel domain DUF2171 PF09939.9 EPA04971.1 - 0.0015 18.8 1.4 0.0057 16.9 2.3 1.5 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2171) Metallothio PF00131.20 EPA04972.1 - 0.069 13.3 21.1 0.43 10.7 21.1 1.9 1 1 0 1 1 1 0 Metallothionein Aminotran_3 PF00202.21 EPA04973.1 - 2.8e-73 246.9 0.0 3.5e-73 246.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EPA04973.1 - 2.7e-06 26.8 0.0 3.6e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II RasGAP_C PF03836.15 EPA04973.1 - 0.031 14.4 0.5 0.084 13.0 0.3 1.8 2 0 0 2 2 2 0 RasGAP C-terminus UPF0051 PF01458.17 EPA04974.1 - 3.9e-63 213.0 0.9 4.9e-63 212.7 0.9 1.1 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) DUF2152 PF10222.9 EPA04974.1 - 0.04 12.3 0.0 0.064 11.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2152) TRAF6_Z2 PF18048.1 EPA04977.1 - 0.047 13.8 0.8 0.15 12.2 0.3 2.1 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 CARD_2 PF16739.5 EPA04977.1 - 0.09 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Caspase recruitment domain DUF1059 PF06348.11 EPA04978.1 - 3.7e-17 62.3 0.9 4.1e-17 62.1 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) Sina PF03145.16 EPA04978.1 - 0.021 14.7 0.1 0.023 14.7 0.1 1.1 1 0 0 1 1 1 0 Seven in absentia protein family Tnp_22_trimer PF17489.2 EPA04978.1 - 0.051 13.6 0.4 0.072 13.1 0.4 1.2 1 0 0 1 1 1 0 L1 transposable element trimerization domain RNase_J_C PF17770.1 EPA04978.1 - 0.053 14.6 0.2 0.063 14.3 0.2 1.1 1 0 0 1 1 1 0 Ribonuclease J C-terminal domain ABC_tran PF00005.27 EPA04979.1 - 7.5e-31 107.5 0.0 1.8e-30 106.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EPA04979.1 - 2.2e-11 44.1 2.7 6.1e-07 29.5 0.1 2.4 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 EPA04979.1 - 1.1e-07 32.5 0.8 2.7e-07 31.2 0.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_15 PF13175.6 EPA04979.1 - 8.5e-05 22.4 4.2 0.013 15.3 0.0 2.9 2 1 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 EPA04979.1 - 0.0014 18.4 0.3 0.0033 17.1 0.3 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EPA04979.1 - 0.0025 18.3 9.4 0.092 13.2 8.0 2.9 1 1 1 2 2 2 1 AAA domain Rad17 PF03215.15 EPA04979.1 - 0.0037 17.2 0.0 0.008 16.1 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain SMC_N PF02463.19 EPA04979.1 - 0.0041 16.6 1.1 0.056 12.9 0.6 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_7 PF12775.7 EPA04979.1 - 0.0088 15.6 0.1 0.015 14.8 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region SRP54 PF00448.22 EPA04979.1 - 0.032 13.8 0.3 0.073 12.7 0.0 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_30 PF13604.6 EPA04979.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EPA04979.1 - 0.2 11.7 1.8 2.2 8.4 1.8 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase F420H2_quin_red PF04075.14 EPA04980.1 - 0.0036 17.4 0.1 0.0041 17.2 0.1 1.1 1 0 0 1 1 1 1 F420H(2)-dependent quinone reductase PRC PF05239.16 EPA04981.1 - 0.00038 20.5 0.0 0.00048 20.1 0.0 1.1 1 0 0 1 1 1 1 PRC-barrel domain nlz1 PF12402.8 EPA04982.1 - 0.059 13.8 0.0 0.081 13.4 0.0 1.2 1 0 0 1 1 1 0 NocA-like zinc-finger protein 1 E1-E2_ATPase PF00122.20 EPA04982.1 - 0.19 11.3 2.2 0.2 11.1 2.2 1.0 1 0 0 1 1 1 0 E1-E2 ATPase PsbX PF06596.11 EPA04982.1 - 0.3 11.1 0.5 0.3 11.1 0.5 1.8 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) MIP PF00230.20 EPA04985.1 - 6e-39 134.1 19.9 7.3e-39 133.8 19.9 1.0 1 0 0 1 1 1 1 Major intrinsic protein Rieske PF00355.26 EPA04986.1 - 2.1e-18 66.0 0.0 2.4e-18 65.8 0.0 1.0 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 EPA04986.1 - 3.7e-13 49.3 0.0 4.2e-13 49.1 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain PAP2 PF01569.21 EPA04987.1 - 0.037 13.8 0.3 0.24 11.2 0.0 2.3 1 1 2 3 3 3 0 PAP2 superfamily LHC PF00556.20 EPA04987.1 - 0.11 12.7 0.8 0.11 12.7 0.8 2.3 2 0 0 2 2 2 0 Antenna complex alpha/beta subunit NifU_N PF01592.16 EPA04988.1 - 2.3e-29 102.1 0.0 2.7e-29 101.9 0.0 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain TSCPD PF12637.7 EPA04988.1 - 0.057 13.7 0.4 0.09 13.0 0.4 1.3 1 0 0 1 1 1 0 TSCPD domain SufE PF02657.15 EPA04988.1 - 0.11 12.4 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Fe-S metabolism associated domain UPF0051 PF01458.17 EPA04990.1 - 1.6e-72 243.8 0.1 2.1e-72 243.4 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) HEAT_2 PF13646.6 EPA04992.1 - 1.3e-07 31.9 0.0 2.1e-06 28.0 0.0 2.5 2 1 0 2 2 2 1 HEAT repeats Cnd1 PF12717.7 EPA04992.1 - 0.011 15.7 0.0 0.023 14.7 0.0 1.6 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EPA04992.1 - 0.042 14.1 0.0 12 6.5 0.0 3.2 3 0 0 3 3 3 0 HEAT repeat CLASP_N PF12348.8 EPA04992.1 - 0.051 13.1 0.0 0.14 11.7 0.0 1.7 1 1 0 1 1 1 0 CLASP N terminal TrmB PF01978.19 EPA04993.1 - 0.012 15.4 0.0 0.044 13.7 0.0 1.9 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Redoxin PF08534.10 EPA04994.1 - 8.6e-07 28.8 0.1 0.00022 21.0 0.0 2.2 1 1 0 2 2 2 2 Redoxin AhpC-TSA PF00578.21 EPA04994.1 - 1.4e-06 28.2 0.1 2.2e-05 24.3 0.0 2.3 2 2 0 2 2 2 1 AhpC/TSA family Thioredoxin_8 PF13905.6 EPA04994.1 - 0.0046 17.3 0.1 4.2 7.8 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_4 PF13462.6 EPA04994.1 - 0.01 16.0 0.0 0.073 13.2 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EPA04994.1 - 0.021 15.2 0.3 0.17 12.3 0.1 2.1 2 0 0 2 2 2 0 Thioredoxin-like domain GSHPx PF00255.19 EPA04994.1 - 0.091 12.3 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione peroxidase Neur_chan_memb PF02932.16 EPA04995.1 - 1.6e-05 25.1 3.0 3.6e-05 23.9 2.7 1.7 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region Cu-binding_MopE PF11617.8 EPA04996.1 - 5.6e-22 77.6 25.6 4.1e-11 42.9 5.6 2.6 2 0 0 2 2 2 2 Putative metal-binding motif SNase PF00565.17 EPA04997.1 - 1e-07 32.4 0.0 1.4e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue SesA PF17107.5 EPA04997.1 - 0.022 14.9 0.0 0.031 14.5 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases CC PF04942.14 EPA04997.1 - 0.086 13.0 0.0 0.23 11.7 0.0 1.7 1 0 0 1 1 1 0 CC domain ABC_tran PF00005.27 EPA04998.1 - 3.4e-19 69.7 0.5 8.4e-19 68.4 0.5 1.6 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EPA04998.1 - 0.00062 19.7 0.5 0.27 11.0 0.0 2.8 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EPA04998.1 - 0.0021 17.5 1.6 0.0047 16.4 1.6 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Met_10 PF02475.16 EPA04999.1 - 1e-46 159.3 0.1 1.1e-46 159.1 0.1 1.0 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.13 EPA04999.1 - 0.00012 21.6 0.1 0.00021 20.8 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EPA04999.1 - 0.0037 16.8 0.0 0.0048 16.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain ADH_zinc_N PF00107.26 EPA04999.1 - 0.037 14.0 0.0 0.26 11.3 0.0 2.1 2 1 0 2 2 2 0 Zinc-binding dehydrogenase DNA_methylase PF00145.17 EPA04999.1 - 0.054 12.8 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Methyltransf_15 PF09445.10 EPA04999.1 - 0.07 12.7 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase FtsJ PF01728.19 EPA04999.1 - 0.13 12.4 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 EPA04999.1 - 0.18 12.5 0.0 0.35 11.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain T2SSE PF00437.20 EPA05001.1 - 1.3e-49 168.7 0.0 2.2e-49 168.0 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 EPA05001.1 - 0.0052 16.2 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family Zeta_toxin PF06414.12 EPA05001.1 - 0.0073 15.6 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_29 PF13555.6 EPA05001.1 - 0.0074 16.0 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EPA05001.1 - 0.012 16.1 0.1 0.099 13.2 0.0 2.2 2 0 0 2 2 2 0 ABC transporter DEAD PF00270.29 EPA05001.1 - 0.07 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_16 PF13191.6 EPA05001.1 - 0.16 12.3 0.1 0.41 11.0 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain GalP_UDP_transf PF01087.22 EPA05002.1 - 3.9e-10 40.5 0.0 1e-09 39.1 0.0 1.7 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain DUF4921 PF16268.5 EPA05002.1 - 0.00035 19.5 0.0 0.00076 18.4 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4921) HIT PF01230.23 EPA05002.1 - 0.00036 21.2 0.0 0.06 14.1 0.0 2.3 2 0 0 2 2 2 1 HIT domain GalP_UDP_tr_C PF02744.17 EPA05002.1 - 0.0018 18.0 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain NTP_transferase PF00483.23 EPA05003.1 - 1e-39 136.6 0.0 1.1e-39 136.5 0.0 1.0 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EPA05003.1 - 2.8e-09 37.5 0.0 3.3e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 EPA05003.1 - 0.07 12.8 0.0 0.15 11.8 0.0 1.5 2 0 0 2 2 2 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Ribosomal_S24e PF01282.19 EPA05004.1 - 3.6e-07 30.0 0.2 5.2e-07 29.5 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S24e GXGXG PF01493.19 EPA05004.1 - 0.063 12.9 0.0 0.092 12.3 0.0 1.2 1 0 0 1 1 1 0 GXGXG motif DUF309 PF03745.14 EPA05005.1 - 2.7e-16 59.0 0.1 4.2e-16 58.4 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF309) DUF5355 PF17306.2 EPA05005.1 - 0.0062 15.6 0.0 0.011 14.8 0.0 1.5 1 1 0 1 1 1 1 Family of unknown function (DUF5355) SprT-like PF10263.9 EPA05006.1 - 0.0087 15.9 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 SprT-like family Ribosomal_S27 PF01599.19 EPA05008.1 - 1.4e-19 70.0 6.2 1.7e-19 69.7 6.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S27a DUF1451 PF07295.11 EPA05008.1 - 0.00028 20.9 0.8 0.00028 20.9 0.8 1.1 1 0 0 1 1 1 1 Zinc-ribbon containing domain Ribosomal_L37e PF01907.19 EPA05008.1 - 0.0084 16.2 2.5 0.014 15.6 2.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e Ephrin_rec_like PF07699.13 EPA05008.1 - 0.011 15.5 1.3 0.014 15.1 1.3 1.3 1 0 0 1 1 1 0 Putative ephrin-receptor like zinc_ribbon_11 PF11682.8 EPA05008.1 - 0.04 13.9 0.8 0.042 13.9 0.1 1.5 1 1 1 2 2 2 0 Probable zinc-ribbon GFA PF04828.14 EPA05008.1 - 0.063 13.6 2.8 0.15 12.5 1.0 1.9 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Nudix_N_2 PF14803.6 EPA05008.1 - 0.33 10.9 5.5 1.7 8.6 3.9 2.2 1 1 1 2 2 2 0 Nudix N-terminal zf-ribbon_3 PF13248.6 EPA05008.1 - 0.45 10.0 6.6 3.2 7.3 0.5 2.2 1 1 1 2 2 2 0 zinc-ribbon domain zf_UBZ PF18439.1 EPA05008.1 - 3.4 7.3 4.9 2.9 7.6 0.3 2.2 1 1 1 2 2 2 0 Ubiquitin-Binding Zinc Finger Acetyltransf_1 PF00583.25 EPA05010.1 - 4.6e-19 68.8 0.0 5.4e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EPA05010.1 - 1.1e-14 54.5 0.0 1.3e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EPA05010.1 - 1.5e-12 47.7 0.1 2.4e-12 47.1 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EPA05010.1 - 3.6e-06 27.1 0.0 4.5e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EPA05010.1 - 0.0022 18.0 0.0 0.096 12.7 0.0 2.4 2 1 0 2 2 2 1 FR47-like protein Acetyltransf_4 PF13420.7 EPA05010.1 - 0.0032 17.6 0.0 0.004 17.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EPA05010.1 - 0.0051 16.9 0.0 0.0079 16.3 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase CdiA_C PF18451.1 EPA05010.1 - 0.17 12.1 2.8 0.53 10.5 0.1 2.4 2 1 0 2 2 2 0 Contact-dependent growth inhibition CdiA C-terminal domain PhosphMutase PF10143.9 EPA05011.1 - 3.9e-44 150.5 0.0 7.8e-44 149.5 0.0 1.5 2 0 0 2 2 2 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Metalloenzyme PF01676.18 EPA05011.1 - 2.3e-30 105.8 0.9 3.2e-30 105.3 0.9 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.22 EPA05011.1 - 0.00077 19.1 0.0 0.023 14.3 0.0 2.1 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase MFS_1 PF07690.16 EPA05012.1 - 2.8e-05 23.2 8.7 3.9e-05 22.7 8.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF202 PF02656.15 EPA05012.1 - 0.2 12.2 3.4 13 6.3 4.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DUF2207 PF09972.9 EPA05012.1 - 9.3 4.9 9.5 2.7 6.7 4.3 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) GNVR PF13807.6 EPA05013.1 - 0.016 15.1 0.1 0.016 15.1 0.1 1.0 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase CbtB PF09489.10 EPA05013.1 - 0.048 13.8 0.1 0.049 13.8 0.1 1.1 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) UCR_Fe-S_N PF10399.9 EPA05013.1 - 0.86 9.0 3.4 1.1 8.6 3.4 1.2 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Pyridox_ox_2 PF12900.7 EPA05014.1 - 5.2e-07 29.8 0.0 6e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 EPA05014.1 - 4.9e-06 26.6 0.0 7.5e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 EPA05014.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.6 1 1 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase like DUF1722 PF08349.11 EPA05015.1 - 3.1e-35 121.0 2.5 5.1e-35 120.3 2.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1722) DNA_photolyase PF00875.18 EPA05016.1 - 1.5e-25 90.1 0.0 1.7e-25 90.0 0.0 1.0 1 0 0 1 1 1 1 DNA photolyase Cdc13_OB4_dimer PF18233.1 EPA05016.1 - 0.046 13.9 0.3 0.064 13.4 0.3 1.4 1 0 0 1 1 1 0 Cdc13 OB4 dimerization domain SPASM PF13186.6 EPA05016.1 - 0.066 13.7 0.1 17 6.0 0.0 2.4 2 1 0 2 2 2 0 Iron-sulfur cluster-binding domain FAD_binding_7 PF03441.14 EPA05017.1 - 5.2e-79 264.4 3.0 7.3e-79 264.0 3.0 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase OprF PF05736.11 EPA05017.1 - 0.0056 16.4 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 OprF membrane domain HD PF01966.22 EPA05019.1 - 7.8e-17 61.6 0.1 1.1e-16 61.1 0.1 1.3 1 0 0 1 1 1 1 HD domain VP9 PF09625.10 EPA05019.1 - 0.051 13.8 0.2 0.13 12.5 0.0 1.7 2 0 0 2 2 2 0 VP9 protein DUF4917 PF16263.5 EPA05019.1 - 0.063 12.6 0.6 0.12 11.7 0.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4917) ClpS PF02617.17 EPA05019.1 - 0.12 12.2 0.1 0.31 10.8 0.1 1.7 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS Amino_oxidase PF01593.24 EPA05020.1 - 9.4e-26 91.1 0.0 1.1e-25 90.8 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EPA05020.1 - 5.5e-11 42.5 0.0 9.8e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EPA05020.1 - 1.7e-05 24.6 0.1 0.017 14.8 0.2 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EPA05020.1 - 7.5e-05 22.1 0.5 0.011 14.9 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EPA05020.1 - 0.0002 21.9 1.3 0.041 14.4 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EPA05020.1 - 0.00021 20.5 0.4 0.018 14.1 0.7 2.1 2 0 0 2 2 2 1 FAD binding domain GDI PF00996.18 EPA05020.1 - 0.0012 17.5 1.2 0.054 12.0 0.1 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor FAD_oxidored PF12831.7 EPA05020.1 - 0.0019 17.7 0.0 0.055 12.8 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EPA05020.1 - 0.0021 17.4 0.7 0.11 11.7 0.1 2.6 3 0 0 3 3 3 1 Thi4 family FAD_binding_3 PF01494.19 EPA05020.1 - 0.0027 17.0 0.1 0.0042 16.4 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EPA05020.1 - 0.0052 15.5 0.2 1.1 7.9 0.2 2.2 2 0 0 2 2 2 2 HI0933-like protein UDPG_MGDP_dh_N PF03721.14 EPA05020.1 - 0.024 14.2 1.1 0.05 13.2 0.2 2.0 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain MCRA PF06100.11 EPA05020.1 - 0.029 13.2 0.0 1.6 7.4 0.0 2.1 2 0 0 2 2 2 0 MCRA family GIDA PF01134.22 EPA05020.1 - 0.066 12.3 1.1 2.8 6.9 0.1 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A zf-FCS PF06467.14 EPA05023.1 - 0.019 14.9 2.5 1.7 8.6 0.1 2.2 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif TF_Zn_Ribbon PF08271.12 EPA05024.1 - 2.1e-05 24.0 0.3 4e-05 23.0 0.3 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding DUF1610 PF07754.11 EPA05024.1 - 0.012 15.5 1.8 0.19 11.7 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) Ribosomal_S27e PF01667.17 EPA05024.1 - 0.35 10.6 3.2 0.48 10.2 0.8 2.0 2 0 0 2 2 2 0 Ribosomal protein S27 TFIIB PF00382.19 EPA05025.1 - 4.1e-23 81.2 2.9 6.9e-12 45.2 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Rrf2 PF02082.20 EPA05025.1 - 0.00027 21.2 0.7 0.42 11.0 0.0 2.8 2 1 1 3 3 3 2 Transcriptional regulator Cyclin_C PF02984.19 EPA05025.1 - 0.024 14.7 0.0 0.07 13.2 0.0 1.7 2 0 0 2 2 2 0 Cyclin, C-terminal domain NAD_binding_10 PF13460.6 EPA05026.1 - 2e-16 60.4 0.0 3.3e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EPA05026.1 - 3e-12 46.5 0.0 3.9e-11 42.9 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EPA05026.1 - 8.8e-11 41.8 0.0 1.3e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 EPA05026.1 - 6.3e-09 35.2 0.0 1.5e-08 34.0 0.0 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EPA05026.1 - 0.00012 21.7 0.0 0.00019 21.0 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EPA05026.1 - 0.0022 17.1 0.0 0.0036 16.5 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EPA05026.1 - 0.018 14.2 0.1 0.056 12.6 0.0 1.9 2 0 0 2 2 2 0 Male sterility protein Polysacc_synt_2 PF02719.15 EPA05026.1 - 0.045 12.9 0.8 0.33 10.0 0.8 2.1 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short PF00106.25 EPA05026.1 - 0.077 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase zf-Dof PF02701.15 EPA05027.1 - 0.47 10.6 6.7 0.87 9.8 6.7 1.5 1 1 0 1 1 1 0 Dof domain, zinc finger B12-binding PF02310.19 EPA05028.1 - 1.6e-13 50.7 0.0 2.7e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 B12 binding domain B12-binding_2 PF02607.17 EPA05028.1 - 2.6e-09 37.4 0.0 4.7e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 B12 binding domain IPPT PF01715.17 EPA05028.1 - 0.065 13.0 0.1 0.93 9.3 0.0 2.1 2 0 0 2 2 2 0 IPP transferase DUF2334 PF10096.9 EPA05029.1 - 5.5e-06 26.2 1.0 1.2e-05 25.1 0.7 1.9 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Polysacc_deac_1 PF01522.21 EPA05029.1 - 0.0012 18.7 0.0 0.0023 17.8 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Ribosomal_L7Ae PF01248.26 EPA05030.1 - 4.3e-12 45.6 0.5 5.3e-12 45.3 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF1694 PF07997.11 EPA05030.1 - 0.033 14.3 1.5 0.033 14.3 1.5 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1694) Ribosomal_S7 PF00177.21 EPA05031.1 - 4.5e-36 123.7 1.1 6.5e-36 123.2 1.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Ribosom_S12_S23 PF00164.25 EPA05032.1 - 2.4e-46 156.0 0.3 3.1e-46 155.7 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 TPR_1 PF00515.28 EPA05033.1 - 2e-20 71.7 0.7 9.3e-08 31.6 0.2 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EPA05033.1 - 1.5e-17 62.2 0.0 1.3e-05 24.9 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 EPA05033.1 - 1e-13 50.6 2.6 0.0011 19.2 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EPA05033.1 - 1e-11 44.3 2.0 1.7e-05 24.4 0.6 3.3 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 EPA05033.1 - 1.2e-11 43.8 2.0 7.8e-05 22.6 0.0 3.0 3 1 0 3 3 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EPA05033.1 - 1.7e-09 37.0 0.0 0.00097 19.0 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EPA05033.1 - 1.4e-07 31.7 0.0 0.04 14.2 0.0 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EPA05033.1 - 4.5e-07 30.2 0.0 0.24 12.3 0.0 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EPA05033.1 - 1.1e-06 29.1 0.0 0.027 15.1 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EPA05033.1 - 1.1e-05 25.9 0.0 0.011 16.2 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EPA05033.1 - 2e-05 24.5 0.1 1.2 9.3 0.0 3.3 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EPA05033.1 - 2.3e-05 24.1 0.2 0.0066 16.3 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat NARP1 PF12569.8 EPA05033.1 - 0.0014 17.6 0.0 0.082 11.8 0.0 2.1 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 EPA05033.1 - 0.0092 16.6 0.2 0.55 11.0 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EPA05033.1 - 0.019 15.1 0.0 0.99 9.6 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 EPA05033.1 - 0.046 13.8 0.0 2.5 8.2 0.0 2.7 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) KH_2 PF07650.17 EPA05034.1 - 1.5e-18 66.3 2.7 2.5e-12 46.4 0.2 2.1 1 1 1 2 2 2 2 KH domain KH_4 PF13083.6 EPA05034.1 - 8.7e-11 41.6 0.5 0.00017 21.4 0.1 2.2 2 0 0 2 2 2 2 KH domain KH_5 PF13184.6 EPA05034.1 - 5.5e-08 32.8 3.1 2.1e-07 30.9 0.3 2.1 2 0 0 2 2 2 1 NusA-like KH domain KH_1 PF00013.29 EPA05034.1 - 0.0005 19.8 0.5 0.043 13.6 0.1 2.3 2 0 0 2 2 2 2 KH domain tRNA-synt_2c PF01411.19 EPA05036.1 - 3.6e-83 280.0 0.0 3.6e-83 280.0 0.0 2.1 2 1 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EPA05036.1 - 5.6e-15 55.2 0.9 1.7e-14 53.6 0.9 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EPA05036.1 - 2.1e-07 31.4 17.0 3e-07 30.9 14.0 2.6 2 1 0 2 2 2 1 DHHA1 domain Slu7 PF11708.8 EPA05036.1 - 0.0097 15.7 1.0 0.019 14.7 1.0 1.4 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor PVL_ORF50 PF07768.11 EPA05036.1 - 0.54 10.6 5.8 1.7 9.0 5.3 2.1 2 0 0 2 2 2 0 PVL ORF-50-like family ATP-synt_E PF05680.12 EPA05036.1 - 4.6 7.7 9.1 2.1 8.7 6.3 1.9 2 0 0 2 2 2 0 ATP synthase E chain Peripla_BP_5 PF13433.6 EPA05038.1 - 2.7e-154 513.5 0.0 3.3e-154 513.3 0.0 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_6 PF13458.6 EPA05038.1 - 2.8e-70 237.7 0.0 3.2e-70 237.5 0.0 1.0 1 0 0 1 1 1 1 Periplasmic binding protein ANF_receptor PF01094.28 EPA05038.1 - 1.4e-08 34.3 0.0 2.9e-08 33.2 0.0 1.4 1 1 0 1 1 1 1 Receptor family ligand binding region HATPase_c PF02518.26 EPA05040.1 - 4e-17 62.7 2.3 4.7e-17 62.5 0.8 2.0 2 0 0 2 2 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 EPA05040.1 - 2.8e-15 56.4 0.3 1.7e-14 53.9 0.0 2.5 2 0 0 2 2 2 1 PAS domain PAS_3 PF08447.12 EPA05040.1 - 3.5e-12 46.4 0.2 1.2e-11 44.7 0.1 2.0 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 EPA05040.1 - 2.2e-10 40.5 0.0 4.8e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 PAS fold dCache_1 PF02743.18 EPA05040.1 - 1.3e-09 38.2 2.3 1.3e-09 38.2 2.3 2.3 3 0 0 3 3 3 1 Cache domain HATPase_c_5 PF14501.6 EPA05040.1 - 1e-08 35.0 1.1 2.6e-08 33.7 0.2 2.2 2 0 0 2 2 2 1 GHKL domain HisKA PF00512.25 EPA05040.1 - 1.2e-08 34.9 2.0 1.5e-08 34.5 0.4 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 EPA05040.1 - 2.5e-07 30.9 0.0 5.3e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 HAMP domain PAS_4 PF08448.10 EPA05040.1 - 4.2e-05 23.7 0.0 8.9e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EPA05040.1 - 0.003 17.6 0.0 0.013 15.5 0.0 2.0 2 0 0 2 2 2 1 PAS domain HATPase_c_3 PF13589.6 EPA05040.1 - 0.011 15.6 0.4 0.095 12.5 0.1 2.6 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EPA05040.1 - 0.05 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain tRNA-synt_1g PF09334.11 EPA05041.1 - 5.6e-14 51.7 0.0 5.6e-14 51.7 0.0 1.3 2 0 0 2 2 2 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EPA05041.1 - 4.9e-08 31.7 0.1 5.4e-08 31.5 0.1 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EPA05041.1 - 0.00056 19.4 0.0 0.00062 19.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.19 EPA05041.1 - 0.0096 14.9 0.0 0.0096 14.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) Rac1 PF09632.10 EPA05042.1 - 0.018 14.2 0.4 0.02 14.1 0.4 1.1 1 0 0 1 1 1 0 Rac1-binding domain RimK PF08443.11 EPA05043.1 - 6e-31 107.5 0.0 8.1e-31 107.1 0.0 1.2 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 EPA05043.1 - 2.2e-11 43.4 0.0 2.9e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATPgrasp_ST PF14397.6 EPA05043.1 - 3e-09 36.5 0.0 3.1e-05 23.4 0.0 2.7 3 0 0 3 3 3 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 EPA05043.1 - 4.8e-08 33.2 0.1 2.9e-07 30.7 0.1 2.0 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_YheCD PF14398.6 EPA05043.1 - 2e-07 30.5 0.0 0.017 14.4 0.0 2.1 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATP-grasp PF02222.22 EPA05043.1 - 7.5e-07 28.9 0.0 1e-05 25.2 0.0 2.3 2 1 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 EPA05043.1 - 0.00019 21.3 0.0 0.00031 20.6 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain CPSase_L_D2 PF02786.17 EPA05043.1 - 0.00035 20.2 0.0 0.0017 17.9 0.0 2.0 3 0 0 3 3 3 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 EPA05043.1 - 0.001 18.6 0.0 0.16 11.5 0.0 2.4 2 1 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp_4 PF13535.6 EPA05043.1 - 0.028 14.0 0.0 0.053 13.1 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_5 PF13549.6 EPA05043.1 - 0.079 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_2 PF08442.10 EPA05043.1 - 0.084 12.4 0.0 0.22 11.0 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain S-methyl_trans PF02574.16 EPA05044.1 - 1.2e-62 212.2 0.0 1.3e-62 212.0 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase ECH_1 PF00378.20 EPA05045.1 - 4.2e-69 232.6 1.0 4.8e-69 232.5 1.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EPA05045.1 - 2.5e-38 132.4 0.9 8e-35 120.9 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase DUF4362 PF14275.6 EPA05045.1 - 0.074 13.3 0.1 0.14 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4362) CTP_transf_like PF01467.26 EPA05047.1 - 1.5e-12 47.9 0.0 2.5e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like Period_C PF12114.8 EPA05047.1 - 0.081 12.5 0.5 0.15 11.6 0.1 1.6 2 0 0 2 2 2 0 Period protein 2/3C-terminal region FAD_syn PF06574.12 EPA05047.1 - 0.085 12.7 0.3 0.56 10.1 0.1 2.1 1 1 1 2 2 2 0 FAD synthetase Arginosuc_synth PF00764.19 EPA05048.1 - 6.7e-153 509.6 0.4 7.7e-153 509.4 0.4 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase HMGL-like PF00682.19 EPA05049.1 - 3.2e-66 223.6 0.0 4.2e-66 223.2 0.0 1.1 1 0 0 1 1 1 1 HMGL-like Radical_SAM PF04055.21 EPA05049.1 - 0.045 14.1 0.4 0.17 12.2 0.1 2.2 3 1 0 3 3 3 0 Radical SAM superfamily TP_methylase PF00590.20 EPA05050.1 - 9.4e-20 71.5 0.0 3.4e-19 69.6 0.0 1.8 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF357 PF04010.13 EPA05050.1 - 3.1e-13 49.6 0.2 9.9e-13 48.0 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF357) Ala_racemase_C PF00842.21 EPA05050.1 - 0.077 12.8 0.0 0.25 11.1 0.0 1.8 2 0 0 2 2 2 0 Alanine racemase, C-terminal domain NMT1_2 PF13379.6 EPA05051.1 - 1.9e-24 86.7 0.0 2.6e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.11 EPA05051.1 - 1.9e-18 67.2 0.0 3.2e-18 66.5 0.0 1.3 1 1 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 EPA05051.1 - 2.4e-08 33.9 0.0 3.6e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 EPA05051.1 - 6e-05 22.6 0.0 0.0045 16.4 0.0 2.2 1 1 1 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 OpuAC PF04069.12 EPA05051.1 - 6.8e-05 22.6 0.0 9.5e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Substrate binding domain of ABC-type glycine betaine transport system NMT1_3 PF16868.5 EPA05051.1 - 0.0078 15.7 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 NMT1-like family ERCC4 PF02732.15 EPA05051.1 - 0.031 14.5 0.0 0.044 14.0 0.0 1.2 1 0 0 1 1 1 0 ERCC4 domain Toprim_4 PF13662.6 EPA05052.1 - 1.1e-07 32.2 0.4 2.5e-07 31.0 0.4 1.6 1 0 0 1 1 1 1 Toprim domain Toprim_2 PF13155.6 EPA05052.1 - 2.8e-05 24.4 0.0 6.2e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Toprim-like Toprim PF01751.22 EPA05052.1 - 0.048 13.9 0.3 0.14 12.4 0.3 1.9 1 1 0 1 1 1 0 Toprim domain zinc_ribbon_4 PF13717.6 EPA05053.1 - 1.3e-06 28.3 3.7 0.0013 18.6 1.3 2.1 1 1 1 2 2 2 2 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 EPA05053.1 - 5.2e-05 23.1 7.1 0.0021 18.0 4.0 2.0 1 1 1 2 2 2 2 PhnA Zinc-Ribbon zf-RING_7 PF02591.15 EPA05053.1 - 0.00011 22.3 0.8 0.0029 17.7 0.1 2.2 2 0 0 2 2 2 1 C4-type zinc ribbon domain zf_UBZ PF18439.1 EPA05053.1 - 0.00035 20.1 2.7 0.32 10.6 0.1 2.3 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger Prok-RING_1 PF14446.6 EPA05053.1 - 0.00071 19.5 2.9 0.0011 18.8 2.9 1.4 1 1 0 1 1 1 1 Prokaryotic RING finger family 1 Zn-ribbon_8 PF09723.10 EPA05053.1 - 0.00089 19.3 2.1 0.0013 18.8 2.1 1.2 1 0 0 1 1 1 1 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 EPA05053.1 - 0.0013 18.2 1.0 0.0016 17.9 1.0 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding zinc_ribbon_5 PF13719.6 EPA05053.1 - 0.0016 18.2 0.4 0.073 12.8 0.0 2.1 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_9 PF14369.6 EPA05053.1 - 0.0019 18.4 0.9 0.0027 17.9 0.9 1.2 1 0 0 1 1 1 1 zinc-ribbon zf-C4_Topoisom PF01396.19 EPA05053.1 - 0.0021 17.8 0.9 0.19 11.5 0.0 2.1 2 0 0 2 2 2 1 Topoisomerase DNA binding C4 zinc finger HypA PF01155.19 EPA05053.1 - 0.0022 18.0 0.5 0.0025 17.8 0.5 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-HYPF PF07503.12 EPA05053.1 - 0.0046 16.7 2.2 0.034 13.9 2.2 1.9 1 1 0 1 1 1 1 HypF finger zf-ribbon_3 PF13248.6 EPA05053.1 - 0.0052 16.2 0.6 0.092 12.2 0.1 2.2 2 0 0 2 2 2 1 zinc-ribbon domain DNA_RNApol_7kD PF03604.13 EPA05053.1 - 0.016 14.9 2.9 0.049 13.3 2.9 1.8 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.7 EPA05053.1 - 0.017 15.1 0.7 0.024 14.6 0.7 1.3 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 EPA05053.1 - 0.019 14.7 1.4 0.97 9.2 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain BssC_TutF PF08201.11 EPA05053.1 - 0.02 14.9 3.0 0.045 13.7 0.4 2.0 1 1 1 2 2 2 0 BssC/TutF protein ADK_lid PF05191.14 EPA05053.1 - 0.041 13.9 0.3 0.23 11.4 0.0 2.0 2 0 0 2 2 2 0 Adenylate kinase, active site lid zinc-ribbons_6 PF07191.12 EPA05053.1 - 0.053 13.5 1.0 0.12 12.4 1.0 1.6 1 1 0 1 1 1 0 zinc-ribbons UPF0547 PF10571.9 EPA05053.1 - 0.072 13.2 5.3 1.5 8.9 0.2 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 A2L_zn_ribbon PF08792.10 EPA05053.1 - 0.078 12.7 3.2 0.59 9.9 3.2 2.0 1 1 0 1 1 1 0 A2L zinc ribbon domain DUF1451 PF07295.11 EPA05053.1 - 0.099 12.7 1.1 0.12 12.5 1.1 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain CpXC PF14353.6 EPA05053.1 - 0.11 12.5 1.7 1 9.4 0.2 2.0 1 1 1 2 2 2 0 CpXC protein RNA_POL_M_15KD PF02150.16 EPA05053.1 - 0.12 12.2 2.2 0.82 9.6 2.2 2.0 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit XPA_N PF01286.18 EPA05053.1 - 0.18 11.9 2.2 12 6.1 0.1 2.1 2 0 0 2 2 2 0 XPA protein N-terminal zf-C2H2 PF00096.26 EPA05053.1 - 0.23 12.0 0.5 3.9 8.1 0.0 2.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-ACC PF17848.1 EPA05053.1 - 0.27 11.3 5.3 6.1 7.0 0.4 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain PADR1 PF08063.12 EPA05053.1 - 0.38 10.6 3.5 1.1 9.0 0.1 2.1 1 1 1 2 2 2 0 PADR1 (NUC008) domain zf-H2C2_2 PF13465.6 EPA05053.1 - 0.73 10.4 2.7 1.6 9.3 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 EPA05053.1 - 0.85 9.7 0.2 0.85 9.7 0.2 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-dskA_traR PF01258.17 EPA05053.1 - 1.2 9.1 6.7 4.8 7.2 6.8 1.8 1 1 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger HTH_5 PF01022.20 EPA05054.1 - 5.3e-10 39.0 0.5 9.8e-10 38.2 0.5 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 EPA05054.1 - 0.0038 17.3 0.1 0.0058 16.7 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 EPA05054.1 - 0.029 14.3 0.1 0.049 13.5 0.1 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 EPA05054.1 - 0.058 13.4 0.2 0.12 12.4 0.2 1.5 1 0 0 1 1 1 0 HTH domain HTH_24 PF13412.6 EPA05054.1 - 0.059 12.9 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_29 PF13551.6 EPA05054.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix BPD_transp_1 PF00528.22 EPA05055.1 - 2e-21 76.6 17.1 2e-21 76.6 17.1 1.5 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF3043 PF11241.8 EPA05055.1 - 0.2 11.7 0.2 0.5 10.4 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) B12-binding PF02310.19 EPA05056.1 - 2.1e-19 69.7 0.0 3.4e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 B12 binding domain B12-binding_2 PF02607.17 EPA05056.1 - 3.3e-19 69.1 0.0 5.6e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 B12 binding domain adh_short PF00106.25 EPA05056.1 - 0.0018 17.8 0.1 0.0065 15.9 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase HTH_AsnC-type PF13404.6 EPA05057.1 - 1.2e-13 50.7 0.0 2.2e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 EPA05057.1 - 1e-12 47.4 0.2 1.7e-12 46.7 0.2 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.21 EPA05057.1 - 3.4e-11 42.9 0.2 5.3e-11 42.3 0.2 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_11 PF08279.12 EPA05057.1 - 0.0015 18.4 0.4 0.0042 17.0 0.1 1.9 2 0 0 2 2 2 1 HTH domain NapD PF03927.13 EPA05057.1 - 0.0024 17.9 1.6 0.0056 16.7 1.0 1.8 1 1 0 1 1 1 1 NapD protein MarR_2 PF12802.7 EPA05057.1 - 0.0027 17.5 0.0 0.0048 16.8 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_5 PF01022.20 EPA05057.1 - 0.0036 17.1 0.0 0.013 15.4 0.0 1.9 2 1 0 2 2 2 1 Bacterial regulatory protein, arsR family ACT_4 PF13291.6 EPA05057.1 - 0.0049 17.4 1.1 2.7 8.6 0.2 2.4 2 0 0 2 2 2 2 ACT domain DUF2774 PF11242.8 EPA05057.1 - 0.0092 16.2 0.3 0.17 12.1 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2774) DDRGK PF09756.9 EPA05057.1 - 0.0092 15.6 2.8 0.035 13.7 0.2 2.1 2 0 0 2 2 2 1 DDRGK domain MarR PF01047.22 EPA05057.1 - 0.011 15.6 0.3 0.027 14.4 0.1 1.7 2 0 0 2 2 2 0 MarR family Sigma70_r4 PF04545.16 EPA05057.1 - 0.012 15.1 0.0 0.032 13.7 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 SCO1-SenC PF02630.14 EPA05057.1 - 0.026 14.4 0.1 0.033 14.1 0.1 1.2 1 0 0 1 1 1 0 SCO1/SenC TrmB PF01978.19 EPA05057.1 - 0.028 14.3 1.2 0.45 10.4 0.1 2.2 1 1 1 2 2 2 0 Sugar-specific transcriptional regulator TrmB Stk19 PF10494.9 EPA05057.1 - 0.044 13.5 0.3 0.047 13.4 0.3 1.3 1 0 0 1 1 1 0 Serine-threonine protein kinase 19 HTH_IclR PF09339.10 EPA05057.1 - 0.045 13.5 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_DeoR PF08220.12 EPA05057.1 - 0.048 13.4 0.4 0.19 11.5 0.1 2.0 2 1 1 3 3 3 0 DeoR-like helix-turn-helix domain Mga PF05043.13 EPA05057.1 - 0.05 14.2 0.1 0.1 13.2 0.1 1.5 1 0 0 1 1 1 0 Mga helix-turn-helix domain HTH_9 PF08221.11 EPA05057.1 - 0.054 13.6 0.1 0.26 11.4 0.0 1.9 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain RTP PF02334.16 EPA05057.1 - 0.068 13.8 0.1 0.1 13.2 0.1 1.3 1 0 0 1 1 1 0 Replication terminator protein ELFV_dehydrog PF00208.21 EPA05058.1 - 2e-67 227.5 1.9 2.7e-67 227.0 1.9 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EPA05058.1 - 9.6e-49 164.6 0.0 1.6e-48 163.8 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Proteasome PF00227.26 EPA05059.1 - 6.2e-48 162.8 2.1 7.9e-48 162.5 2.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EPA05059.1 - 1.6e-12 46.8 1.7 1.3e-10 40.8 0.2 2.7 2 0 0 2 2 2 2 Proteasome subunit A N-terminal signature CTP-dep_RFKase PF01982.16 EPA05060.1 - 3.7e-41 140.0 0.1 5.5e-41 139.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF120 Phage_rep_O PF04492.13 EPA05060.1 - 0.029 15.0 1.7 1.6 9.4 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage replication protein O HicB PF05534.12 EPA05060.1 - 0.11 12.4 0.0 0.52 10.2 0.0 2.0 2 0 0 2 2 2 0 HicB family Aminotran_3 PF00202.21 EPA05061.1 - 5.3e-116 387.6 0.0 6.7e-116 387.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EPA05061.1 - 0.0011 18.2 0.0 0.0023 17.1 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II DUF2931 PF11153.8 EPA05061.1 - 0.062 13.0 0.0 0.098 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2931) GATase PF00117.28 EPA05062.1 - 8.7e-23 81.1 0.0 1.3e-22 80.6 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EPA05062.1 - 1.6e-06 28.1 0.2 1.9e-05 24.5 0.0 2.4 2 1 0 2 2 2 1 Peptidase C26 HTS PF04204.16 EPA05062.1 - 5.4e-06 25.5 0.0 1e-05 24.7 0.0 1.4 2 0 0 2 2 2 1 Homoserine O-succinyltransferase GATase_3 PF07685.14 EPA05062.1 - 0.019 14.6 0.4 0.027 14.1 0.0 1.5 2 0 0 2 2 2 0 CobB/CobQ-like glutamine amidotransferase domain INTS5_N PF14837.6 EPA05062.1 - 0.12 11.9 0.2 0.18 11.4 0.2 1.2 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus DJ-1_PfpI PF01965.24 EPA05062.1 - 0.16 11.7 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family Pterin_bind PF00809.22 EPA05063.1 - 2.4e-31 109.3 0.0 2.8e-31 109.0 0.0 1.0 1 0 0 1 1 1 1 Pterin binding enzyme CdhD PF03599.16 EPA05063.1 - 3e-05 22.9 0.0 3.7e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit N6_N4_Mtase PF01555.18 EPA05064.1 - 4.6e-36 124.7 4.9 5.6e-36 124.4 4.9 1.1 1 0 0 1 1 1 1 DNA methylase UPF0020 PF01170.18 EPA05064.1 - 0.00012 21.8 0.0 0.049 13.3 0.0 2.4 3 0 0 3 3 3 2 Putative RNA methylase family UPF0020 N6-adenineMlase PF10237.9 EPA05064.1 - 0.003 17.4 0.1 0.0058 16.4 0.1 1.7 2 0 0 2 2 2 1 Probable N6-adenine methyltransferase MTS PF05175.14 EPA05064.1 - 0.11 12.0 0.0 0.55 9.8 0.1 2.0 2 0 0 2 2 2 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EPA05065.1 - 2.1e-17 63.3 0.0 2.5e-17 63.0 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EPA05065.1 - 6.5e-12 45.9 0.0 9.2e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA05065.1 - 1.3e-11 45.0 0.0 1.9e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EPA05065.1 - 3.8e-07 30.1 0.0 4.5e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA05065.1 - 5.4e-07 29.5 0.0 9.8e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA05065.1 - 2.6e-05 24.9 0.0 4.5e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EPA05065.1 - 0.08 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase P-II PF00543.22 EPA05066.1 - 1.2e-18 67.6 1.4 3.9e-18 65.9 1.4 1.7 1 1 0 1 1 1 1 Nitrogen regulatory protein P-II DUF2179 PF10035.9 EPA05066.1 - 0.074 12.8 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2179) CaM-KIIN PF15170.6 EPA05066.1 - 0.13 12.4 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Calcium/calmodulin-dependent protein kinase II inhibitor Fe-S_biosyn PF01521.20 EPA05067.1 - 7.5e-22 77.6 0.0 8.4e-22 77.5 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis RimK PF08443.11 EPA05068.1 - 1.9e-30 105.9 0.0 2.4e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 EPA05068.1 - 1.4e-08 34.3 0.0 1.9e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.14 EPA05068.1 - 2.9e-07 30.7 0.0 4.7e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 EPA05068.1 - 0.00028 20.2 0.1 0.27 10.4 0.0 2.5 1 1 0 2 2 2 2 Sugar-transfer associated ATP-grasp CPSase_L_D2 PF02786.17 EPA05068.1 - 0.0068 15.9 0.0 0.013 15.0 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_5 PF13549.6 EPA05068.1 - 0.053 13.0 0.0 0.091 12.2 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp PF02222.22 EPA05068.1 - 0.059 12.9 0.0 0.11 12.0 0.0 1.6 1 1 0 1 1 1 0 ATP-grasp domain ATPgrasp_YheCD PF14398.6 EPA05068.1 - 0.065 12.5 0.0 7.8 5.7 0.0 2.3 1 1 1 2 2 2 0 YheC/D like ATP-grasp MFS_1 PF07690.16 EPA05069.1 - 1.5e-25 89.9 37.6 9.3e-23 80.7 22.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EPA05069.1 - 2.3e-06 26.7 23.7 7.1e-06 25.1 22.2 2.2 1 1 0 1 1 1 1 MFS_1 like family Sugar_tr PF00083.24 EPA05069.1 - 5.2e-06 25.6 8.9 5.2e-06 25.6 8.9 3.0 2 1 1 3 3 3 2 Sugar (and other) transporter DUF4094 PF13334.6 EPA05069.1 - 0.047 14.1 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) MFS_1 PF07690.16 EPA05071.1 - 4.7e-42 144.2 70.6 4.9e-31 107.9 36.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EPA05071.1 - 1.1e-12 47.9 16.8 1.4e-12 47.7 16.8 1.0 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 EPA05071.1 - 0.0018 16.7 13.6 0.0074 14.7 13.6 1.9 1 1 0 1 1 1 1 Transmembrane secretion effector PUCC PF03209.15 EPA05071.1 - 0.0039 16.3 14.6 0.0044 16.1 8.0 2.2 2 0 0 2 2 2 2 PUCC protein MASE2 PF05230.11 EPA05071.1 - 0.0052 16.8 3.0 0.0067 16.5 0.3 2.6 2 1 0 2 2 2 1 MASE2 domain Phage_holin_8 PF16931.5 EPA05071.1 - 0.016 15.1 0.1 0.016 15.1 0.1 2.7 3 0 0 3 3 3 0 Putative phage holin OATP PF03137.20 EPA05071.1 - 0.07 11.4 17.2 0.06 11.6 2.5 3.7 1 1 2 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family DUF5553 PF17707.1 EPA05071.1 - 0.1 12.1 0.3 0.21 11.0 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5553) MttA_Hcf106 PF02416.16 EPA05072.1 - 4e-07 29.2 0.1 5e-07 29.0 0.1 1.2 1 1 0 1 1 1 1 mttA/Hcf106 family DLP_helical PF18709.1 EPA05072.1 - 0.00048 19.4 0.4 0.00055 19.2 0.4 1.0 1 0 0 1 1 1 1 Dynamin-like helical domain Phage_Mu_Gam PF07352.12 EPA05072.1 - 0.0006 19.7 0.1 0.00068 19.6 0.1 1.1 1 0 0 1 1 1 1 Bacteriophage Mu Gam like protein COG2 PF06148.11 EPA05072.1 - 0.035 14.2 0.1 0.044 13.9 0.1 1.2 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3852 PF12963.7 EPA05072.1 - 0.072 13.4 0.1 0.2 12.0 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3852) Peptidase_M20 PF01546.28 EPA05073.1 - 2.1e-28 99.4 0.5 3.9e-28 98.6 0.5 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EPA05073.1 - 2.1e-11 43.7 0.0 4.4e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M42 PF05343.14 EPA05073.1 - 8.1e-05 21.8 0.9 0.17 10.9 0.1 2.6 2 1 1 3 3 3 2 M42 glutamyl aminopeptidase Peptidase_M28 PF04389.17 EPA05073.1 - 0.002 17.8 0.0 0.0032 17.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Toprim PF01751.22 EPA05074.1 - 0.00028 21.0 0.1 0.0026 18.0 0.1 2.1 1 1 0 1 1 1 1 Toprim domain Toprim_4 PF13662.6 EPA05074.1 - 0.00064 20.1 0.0 0.0064 16.9 0.0 2.1 1 1 0 1 1 1 1 Toprim domain Toprim_2 PF13155.6 EPA05074.1 - 0.0046 17.4 0.0 0.0081 16.6 0.0 1.5 1 1 0 1 1 1 1 Toprim-like Semialdhyde_dh PF01118.24 EPA05075.1 - 2e-35 121.9 0.0 3.3e-35 121.2 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 EPA05075.1 - 4.8e-19 69.2 0.0 8e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Sacchrp_dh_NADP PF03435.18 EPA05075.1 - 9.6e-05 22.6 0.0 0.00016 21.9 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain GFO_IDH_MocA PF01408.22 EPA05075.1 - 0.00049 20.9 0.0 0.00096 20.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DapB_N PF01113.20 EPA05075.1 - 0.0006 19.9 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.17 EPA05075.1 - 0.1 13.2 0.0 0.2 12.3 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ATP-grasp_5 PF13549.6 EPA05076.1 - 3.6e-67 226.1 0.7 5.5e-67 225.5 0.7 1.3 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 EPA05076.1 - 1e-48 164.6 0.2 2.5e-48 163.4 0.2 1.7 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EPA05076.1 - 6.8e-24 84.6 0.1 2.3e-23 82.9 0.0 2.0 2 0 0 2 2 2 1 CoA binding domain ATP-grasp_2 PF08442.10 EPA05076.1 - 5.4e-08 32.6 0.8 1.1e-07 31.6 0.8 1.5 1 0 0 1 1 1 1 ATP-grasp domain CoA_binding PF02629.19 EPA05076.1 - 1.1e-07 32.4 1.7 5.3e-07 30.2 0.2 3.0 3 0 0 3 3 3 1 CoA binding domain ATP-grasp PF02222.22 EPA05076.1 - 0.015 14.9 0.0 0.034 13.7 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain AA_kinase PF00696.28 EPA05077.1 - 1.6e-38 132.7 3.3 1.8e-38 132.5 3.3 1.0 1 0 0 1 1 1 1 Amino acid kinase family DUF5603 PF18231.1 EPA05077.1 - 0.094 13.0 2.0 0.28 11.5 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5603) DUF4947 PF16305.5 EPA05077.1 - 0.11 12.5 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4947) zinc_ribbon_4 PF13717.6 EPA05078.1 - 0.0002 21.2 0.6 0.14 12.1 0.1 2.1 2 0 0 2 2 2 2 zinc-ribbon domain zinc_ribbon_5 PF13719.6 EPA05078.1 - 0.0017 18.0 0.6 0.11 12.3 0.1 2.2 2 0 0 2 2 2 1 zinc-ribbon domain RNA_POL_M_15KD PF02150.16 EPA05078.1 - 0.003 17.4 0.2 0.0046 16.8 0.2 1.3 1 0 0 1 1 1 1 RNA polymerases M/15 Kd subunit TF_Zn_Ribbon PF08271.12 EPA05078.1 - 0.0034 16.9 0.7 0.0052 16.3 0.5 1.4 2 0 0 2 2 2 1 TFIIB zinc-binding zf_UBZ PF18439.1 EPA05078.1 - 0.038 13.6 1.6 2.8 7.6 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zinc-ribbons_6 PF07191.12 EPA05078.1 - 0.047 13.7 0.5 0.073 13.1 0.5 1.3 1 1 0 1 1 1 0 zinc-ribbons DNA_RNApol_7kD PF03604.13 EPA05078.1 - 0.066 12.9 4.0 1 9.1 0.4 2.5 1 1 1 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.19 EPA05078.1 - 0.068 13.2 0.6 0.076 13.0 0.6 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 EPA05078.1 - 0.079 13.1 2.7 0.8 9.9 0.1 2.0 1 1 1 2 2 2 0 Zinc ribbon domain zf-HYPF PF07503.12 EPA05078.1 - 0.12 12.2 1.4 0.51 10.1 0.0 2.0 2 0 0 2 2 2 0 HypF finger Lar_restr_allev PF14354.6 EPA05078.1 - 0.13 12.7 1.4 0.47 10.9 1.4 1.9 1 1 0 1 1 1 0 Restriction alleviation protein Lar SR1P PF13790.6 EPA05078.1 - 0.18 12.0 2.4 1.9 8.7 0.1 2.1 1 1 1 2 2 2 0 SR1 protein ABC_tran PF00005.27 EPA05079.1 - 3.1e-31 108.7 0.0 5.2e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EPA05079.1 - 1.3e-08 35.1 0.0 0.0043 16.9 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EPA05079.1 - 0.00089 19.2 0.1 0.0019 18.1 0.0 1.6 2 0 0 2 2 2 1 RsgA GTPase AAA PF00004.29 EPA05079.1 - 0.0014 19.1 0.3 0.014 15.8 0.3 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 EPA05079.1 - 0.0045 16.7 0.0 0.1 12.3 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 EPA05079.1 - 0.0056 16.6 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_29 PF13555.6 EPA05079.1 - 0.0061 16.3 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 EPA05079.1 - 0.012 15.0 0.2 1.8 7.9 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EPA05079.1 - 0.02 15.3 0.0 0.032 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EPA05079.1 - 0.02 15.2 0.1 0.055 13.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EPA05079.1 - 0.021 14.9 0.0 0.039 14.0 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_5 PF07728.14 EPA05079.1 - 0.025 14.6 0.0 0.066 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EPA05079.1 - 0.028 14.1 0.0 0.4 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EPA05079.1 - 0.029 14.9 0.0 0.056 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EPA05079.1 - 0.031 14.0 0.1 0.17 11.6 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.6 EPA05079.1 - 0.038 13.5 0.0 0.079 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EPA05079.1 - 0.05 14.0 0.0 0.19 12.1 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_33 PF13671.6 EPA05079.1 - 0.052 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EPA05079.1 - 0.061 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 EPA05079.1 - 0.15 12.6 0.0 0.25 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain zf-RRN7 PF11781.8 EPA05080.1 - 0.0015 18.1 2.6 0.0035 17.0 2.6 1.6 1 1 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Fe_dep_repr_C PF02742.15 EPA05081.1 - 1.3e-18 66.8 0.2 1.6e-18 66.6 0.2 1.1 1 0 0 1 1 1 1 Iron dependent repressor, metal binding and dimerisation domain UPF0047 PF01894.17 EPA05082.1 - 7e-08 32.6 0.0 7.3e-08 32.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 Radical_SAM PF04055.21 EPA05083.1 - 8.6e-15 55.5 0.0 1.2e-14 55.0 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily DUF905 PF06006.12 EPA05083.1 - 0.17 11.9 0.0 0.58 10.2 0.0 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF905) DUF2748 PF10871.8 EPA05084.1 - 0.05 12.2 0.2 0.056 12.1 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2748) UbiD PF01977.16 EPA05086.1 - 1.9e-152 507.9 0.0 2.2e-152 507.7 0.0 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Aminotran_3 PF00202.21 EPA05087.1 - 3e-56 190.8 0.0 3.7e-56 190.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III VIT1 PF01988.19 EPA05089.1 - 2e-24 86.6 0.1 2.5e-24 86.4 0.1 1.1 1 0 0 1 1 1 1 VIT family MG2 PF01835.19 EPA05090.1 - 0.0001 22.7 0.1 0.28 11.7 0.0 2.3 2 0 0 2 2 2 2 MG2 domain FlgD_ig PF13860.6 EPA05090.1 - 0.0014 18.5 0.9 0.045 13.6 0.1 2.5 2 0 0 2 2 2 1 FlgD Ig-like domain PsbH PF00737.20 EPA05090.1 - 0.018 14.8 0.2 0.043 13.6 0.2 1.6 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein TrmB PF01978.19 EPA05091.1 - 3.7e-15 55.6 0.0 2.1e-14 53.1 0.0 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 EPA05091.1 - 0.00032 20.6 0.0 0.0012 18.8 0.0 1.9 2 0 0 2 2 2 1 MarR family MarR_2 PF12802.7 EPA05091.1 - 0.00047 20.0 0.0 0.0008 19.3 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_11 PF08279.12 EPA05091.1 - 0.0015 18.4 0.1 0.0044 16.9 0.0 1.9 2 0 0 2 2 2 1 HTH domain Fe_dep_repress PF01325.19 EPA05091.1 - 0.0017 18.5 0.0 0.0082 16.3 0.0 2.1 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain HTH_24 PF13412.6 EPA05091.1 - 0.0039 16.7 0.0 0.0077 15.8 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding FtsK_gamma PF09397.10 EPA05091.1 - 0.019 14.7 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 Ftsk gamma domain HTH_IclR PF09339.10 EPA05091.1 - 0.066 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain Pedibin PF08182.11 EPA05091.1 - 0.13 12.1 1.3 0.26 11.1 1.3 1.5 1 0 0 1 1 1 0 Pedibin/Hym-346 family RimK PF08443.11 EPA05092.1 - 0.023 14.3 0.2 0.024 14.2 0.2 1.1 1 0 0 1 1 1 0 RimK-like ATP-grasp domain VIT1 PF01988.19 EPA05093.1 - 4.1e-05 23.6 3.3 4.4e-05 23.5 3.3 1.0 1 0 0 1 1 1 1 VIT family MFS_1 PF07690.16 EPA05094.1 - 2.1e-27 96.0 65.9 4.1e-21 75.3 33.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EPA05094.1 - 2e-06 26.9 31.4 3.8e-06 26.0 31.4 1.4 1 1 0 1 1 1 1 MFS_1 like family MFS_2 PF13347.6 EPA05094.1 - 0.0022 16.6 5.2 0.0022 16.6 5.2 3.8 2 2 1 3 3 3 1 MFS/sugar transport protein MFS_3 PF05977.13 EPA05094.1 - 0.021 13.3 7.4 0.22 9.8 1.8 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector TM_helix PF05552.12 EPA05095.1 - 1.4e-11 44.1 12.1 7.9e-07 29.0 0.2 3.1 3 0 0 3 3 3 2 Conserved TM helix MS_channel PF00924.18 EPA05095.1 - 5.4e-07 29.4 8.0 5.4e-07 29.4 8.0 3.2 3 1 0 3 3 3 1 Mechanosensitive ion channel HalOD2 PF18547.1 EPA05096.1 - 0.074 13.0 0.8 0.13 12.2 0.1 1.7 2 0 0 2 2 2 0 Halobacterial output domain 2 DUF4428 PF14471.6 EPA05096.1 - 0.11 12.5 3.1 0.75 9.8 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4428) Gemini_V2 PF01524.17 EPA05096.1 - 0.14 12.4 0.0 0.16 12.2 0.0 1.1 1 0 0 1 1 1 0 Geminivirus V2 protein Phos_pyr_kin PF08543.12 EPA05097.1 - 4.3e-73 245.7 0.9 4.3e-73 245.7 0.9 1.4 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase ThiP_synth PF10120.9 EPA05097.1 - 2e-29 102.4 0.0 3.9e-29 101.4 0.0 1.5 1 0 0 1 1 1 1 Thiamine-phosphate synthase PfkB PF00294.24 EPA05097.1 - 2.9e-10 39.9 0.0 4.6e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Carb_kinase PF01256.17 EPA05097.1 - 0.00067 19.2 0.1 0.0013 18.3 0.1 1.5 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 EPA05097.1 - 0.027 13.9 0.4 0.11 11.9 0.4 1.9 1 1 0 1 1 1 0 Hydroxyethylthiazole kinase family Baculo_PEP_C PF04513.12 EPA05098.1 - 0.0043 17.1 3.7 0.0099 15.9 3.7 1.6 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Y_Y_Y PF07495.13 EPA05098.1 - 0.012 15.6 0.3 7.5 6.6 0.0 2.5 2 0 0 2 2 2 0 Y_Y_Y domain DUF1664 PF07889.12 EPA05098.1 - 0.039 14.0 0.3 0.1 12.7 0.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Filamin PF00630.19 EPA05098.1 - 0.052 14.4 0.0 0.16 12.8 0.0 1.8 2 1 0 2 2 2 0 Filamin/ABP280 repeat BLOC1_2 PF10046.9 EPA05098.1 - 0.071 13.4 0.2 0.15 12.4 0.2 1.5 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.12 EPA05098.1 - 0.093 12.8 0.3 0.15 12.1 0.3 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein FlaC_arch PF05377.11 EPA05098.1 - 0.35 11.3 4.4 0.52 10.7 2.2 2.5 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Ran-binding PF05508.11 EPA05098.1 - 0.46 9.4 3.3 0.18 10.7 0.8 1.5 2 0 0 2 2 2 0 RanGTP-binding protein CarboxypepD_reg PF13620.6 EPA05099.1 - 5.4e-06 26.6 0.0 1e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EPA05099.1 - 0.0027 17.7 0.0 0.0089 16.0 0.0 1.9 1 0 0 1 1 1 1 CarboxypepD_reg-like domain Big_1 PF02369.16 EPA05099.1 - 0.064 13.3 0.1 0.16 12.0 0.1 1.6 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) GSDH PF07995.11 EPA05100.1 - 8.1e-32 110.8 0.0 3.6e-31 108.7 0.0 1.8 1 1 0 1 1 1 1 Glucose / Sorbosone dehydrogenase HALZ PF02183.18 EPA05102.1 - 0.022 15.0 4.1 0.033 14.4 4.1 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper Herpes_BLRF2 PF05812.12 EPA05102.1 - 0.036 14.2 2.4 0.045 13.9 2.4 1.2 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein NRBF2 PF08961.10 EPA05102.1 - 0.051 13.2 4.0 0.058 13.0 4.0 1.0 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator DivIC PF04977.15 EPA05102.1 - 0.077 12.8 2.1 0.084 12.7 1.9 1.3 1 1 0 1 1 1 0 Septum formation initiator DUF5595 PF18077.1 EPA05102.1 - 0.08 13.0 3.9 0.098 12.7 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) ZapB PF06005.12 EPA05102.1 - 0.12 12.8 7.6 0.06 13.8 5.2 1.7 1 1 1 2 2 2 0 Cell division protein ZapB YabA PF06156.13 EPA05102.1 - 0.46 11.1 3.5 0.46 11.2 3.5 1.1 1 0 0 1 1 1 0 Initiation control protein YabA fn3 PF00041.21 EPA05103.1 - 5e-32 110.1 18.8 8.6e-13 48.5 3.0 3.2 3 0 0 3 3 3 3 Fibronectin type III domain PilX PF13681.6 EPA05103.1 - 0.028 14.8 4.9 0.13 12.7 1.3 2.5 1 1 1 2 2 2 0 Type IV pilus assembly protein PilX C-term SPESP1 PF15754.5 EPA05103.1 - 0.037 13.2 7.4 0.031 13.4 2.2 2.2 2 0 0 2 2 2 0 Sperm equatorial segment protein 1 Fimbrillin_C PF15495.6 EPA05103.1 - 0.045 14.2 3.8 0.66 10.4 0.8 2.6 2 1 0 2 2 2 0 Major fimbrial subunit protein type IV, Fimbrillin, C-terminal Collagen_bind_2 PF12904.7 EPA05103.1 - 0.1 12.6 0.4 6.3 6.9 0.0 2.8 3 1 0 3 3 3 0 Putative collagen-binding domain of a collagenase DUF4249 PF14054.6 EPA05103.1 - 0.12 12.0 17.4 0.064 12.9 13.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4249) MG2 PF01835.19 EPA05104.1 - 0.0095 16.4 0.0 0.012 16.0 0.0 1.2 1 0 0 1 1 1 1 MG2 domain MG2 PF01835.19 EPA05105.1 - 1.6e-12 47.7 0.1 2e-05 25.0 0.0 4.3 5 0 0 5 5 5 3 MG2 domain Arrestin_C PF02752.22 EPA05105.1 - 0.032 14.7 0.8 0.59 10.6 0.1 3.1 2 1 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain Glyco_hydro_66 PF13199.6 EPA05105.1 - 0.11 11.1 0.0 1.5 7.4 0.0 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 66 GvpO PF05800.11 EPA05105.1 - 0.15 12.1 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpO He_PIG PF05345.12 EPA05105.1 - 0.72 10.1 4.0 15 5.9 0.3 3.3 3 0 0 3 3 3 0 Putative Ig domain UPF0047 PF01894.17 EPA05107.1 - 1.8e-21 76.5 0.1 2.3e-21 76.1 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 eRF1_1 PF03463.15 EPA05108.1 - 3.7e-20 72.2 0.3 4.8e-20 71.9 0.3 1.1 1 0 0 1 1 1 1 eRF1 domain 1 TruB_N PF01509.18 EPA05110.1 - 2.2e-25 89.8 0.2 3.2e-15 56.8 0.0 3.3 1 1 1 2 2 2 2 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EPA05110.1 - 1.1e-19 70.3 0.0 5.6e-19 68.0 0.0 2.2 2 0 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 EPA05110.1 - 1.2e-19 70.0 0.1 2.1e-19 69.3 0.1 1.4 1 0 0 1 1 1 1 PUA domain DKCLD PF08068.12 EPA05110.1 - 4.4e-12 45.9 0.0 1.3e-11 44.3 0.0 1.8 2 0 0 2 2 2 1 DKCLD (NUC011) domain UPF0113 PF03657.13 EPA05110.1 - 0.13 12.5 0.0 1 9.7 0.0 2.4 2 0 0 2 2 2 0 UPF0113 PUA domain TIR-like PF10137.9 EPA05111.1 - 0.05 13.6 0.0 0.096 12.6 0.0 1.4 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain DUF473 PF04322.12 EPA05111.1 - 0.08 12.8 0.2 0.12 12.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF473) Ribosomal_S5 PF00333.20 EPA05112.1 - 4.3e-22 77.9 0.8 7.9e-22 77.0 0.8 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EPA05112.1 - 3.6e-16 58.4 0.3 8.4e-16 57.2 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain RhlB PF12300.8 EPA05112.1 - 1.4 9.0 11.6 2.1 8.4 11.6 1.3 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB DAO PF01266.24 EPA05113.1 - 1.1e-41 143.7 0.0 1.4e-41 143.3 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Mqo PF06039.15 EPA05113.1 - 2.2e-16 59.5 0.0 1.1e-09 37.4 0.0 2.1 2 0 0 2 2 2 2 Malate:quinone oxidoreductase (Mqo) NAD_binding_8 PF13450.6 EPA05113.1 - 0.0016 18.7 0.0 0.0039 17.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EPA05113.1 - 0.0024 18.4 3.3 1.4 9.5 0.0 3.6 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EPA05113.1 - 0.0026 17.0 0.7 1.4 8.1 0.1 2.3 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase PepSY_like PF11396.8 EPA05113.1 - 0.13 12.9 4.3 0.33 11.5 0.2 3.2 2 1 1 3 3 3 0 Putative beta-lactamase-inhibitor-like, PepSY-like Ribosomal_L30 PF00327.20 EPA05115.1 - 3.3e-12 46.1 0.0 5.4e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e FeS PF04060.13 EPA05115.1 - 0.13 11.9 0.6 0.74 9.5 0.0 2.3 3 0 0 3 3 3 0 Putative Fe-S cluster SHOCT PF09851.9 EPA05117.1 - 1.2e-06 28.0 6.7 2.3e-06 27.2 6.7 1.4 1 0 0 1 1 1 1 Short C-terminal domain GvpG PF05120.12 EPA05117.1 - 0.023 14.7 0.0 0.047 13.7 0.0 1.5 1 0 0 1 1 1 0 Gas vesicle protein G TSP_NTD PF17804.1 EPA05117.1 - 1.2 9.4 10.9 1.4 9.1 10.9 1.3 1 1 0 1 1 1 0 Tail specific protease N-terminal domain FlgD_ig PF13860.6 EPA05118.1 - 0.12 12.3 0.0 0.43 10.5 0.0 2.0 1 1 0 1 1 1 0 FlgD Ig-like domain zf-ribbon_3 PF13248.6 EPA05119.1 - 0.002 17.4 7.5 0.0032 16.8 7.5 1.4 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_2 PF13240.6 EPA05119.1 - 0.026 14.2 8.8 0.052 13.3 8.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain AAA_17 PF13207.6 EPA05120.1 - 1.9e-32 112.5 0.0 2.7e-32 112.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EPA05120.1 - 1.1e-06 29.2 0.0 1.8e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EPA05120.1 - 7.2e-05 22.4 0.3 0.0001 21.9 0.3 1.3 1 1 0 1 1 1 1 Chromatin associated protein KTI12 Roc PF08477.13 EPA05120.1 - 7.8e-05 22.9 0.1 0.00014 22.1 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 EPA05120.1 - 8e-05 22.6 2.4 0.0012 18.8 0.4 2.2 1 1 0 2 2 2 1 NTPase AAA_28 PF13521.6 EPA05120.1 - 0.00015 22.1 0.0 0.00022 21.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EPA05120.1 - 0.00024 20.9 0.0 0.00037 20.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EPA05120.1 - 0.00036 20.5 0.0 0.00049 20.1 0.0 1.3 1 0 0 1 1 1 1 NACHT domain SRP54 PF00448.22 EPA05120.1 - 0.00039 20.1 0.3 0.00077 19.1 0.2 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA PF00004.29 EPA05120.1 - 0.00041 20.8 0.1 0.0008 19.8 0.1 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EPA05120.1 - 0.00059 20.4 1.2 0.00071 20.1 1.2 1.5 1 1 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 EPA05120.1 - 0.00065 20.0 0.0 0.00089 19.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EPA05120.1 - 0.00073 19.5 0.1 0.0013 18.7 0.1 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EPA05120.1 - 0.00074 19.9 0.2 0.001 19.4 0.2 1.6 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 EPA05120.1 - 0.00077 19.1 0.1 0.0014 18.2 0.1 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 EPA05120.1 - 0.0015 18.6 0.5 0.0022 18.1 0.5 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 EPA05120.1 - 0.0019 18.4 0.0 0.0029 17.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EPA05120.1 - 0.0024 18.3 0.0 0.0029 18.0 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EPA05120.1 - 0.0027 17.4 0.0 0.0047 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain MobB PF03205.14 EPA05120.1 - 0.0032 17.3 0.2 0.0061 16.5 0.2 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Mg_chelatase PF01078.21 EPA05120.1 - 0.0075 15.7 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATP_bind_1 PF03029.17 EPA05120.1 - 0.0076 16.1 0.3 0.017 14.9 0.1 1.7 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EPA05120.1 - 0.011 15.7 0.5 0.026 14.4 0.2 1.7 2 0 0 2 2 2 0 RsgA GTPase CLP1_P PF16575.5 EPA05120.1 - 0.011 15.5 0.2 0.19 11.5 0.0 2.6 2 1 1 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_5 PF07728.14 EPA05120.1 - 0.012 15.6 0.1 0.026 14.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EPA05120.1 - 0.014 15.0 0.1 0.02 14.4 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region MeaB PF03308.16 EPA05120.1 - 0.015 14.3 0.2 0.026 13.5 0.2 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Viral_helicase1 PF01443.18 EPA05120.1 - 0.018 14.8 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Ras PF00071.22 EPA05120.1 - 0.022 14.3 0.5 0.044 13.4 0.3 1.6 2 0 0 2 2 1 0 Ras family DnaB_C PF03796.15 EPA05120.1 - 0.023 14.1 0.0 0.041 13.2 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_14 PF13173.6 EPA05120.1 - 0.027 14.5 0.6 0.059 13.4 0.1 1.8 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EPA05120.1 - 0.038 13.2 0.0 0.063 12.5 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Thymidylate_kin PF02223.17 EPA05120.1 - 0.048 13.3 0.3 0.15 11.8 0.3 2.1 1 1 0 1 1 1 0 Thymidylate kinase POR_N PF01855.19 EPA05122.1 - 7e-56 189.6 0.0 1e-55 189.0 0.0 1.2 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg POR PF01558.18 EPA05122.1 - 1.8e-26 93.3 0.0 3.7e-26 92.3 0.0 1.5 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase PFOR_II PF17147.4 EPA05122.1 - 7.9e-12 45.4 0.0 1.6e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Transketolase_C PF02780.20 EPA05122.1 - 6.6e-06 26.0 0.0 1.4e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain TBP PF00352.21 EPA05123.1 - 3.1e-53 177.7 0.0 1.8e-26 91.9 0.0 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EPA05123.1 - 1.1e-07 31.8 0.0 0.0025 17.9 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) FlgH PF02107.16 EPA05123.1 - 0.0053 16.4 0.3 0.009 15.6 0.3 1.4 1 0 0 1 1 1 1 Flagellar L-ring protein SecY PF00344.20 EPA05124.1 - 2.7e-61 207.5 17.1 3.5e-61 207.1 17.1 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EPA05124.1 - 1.7e-11 43.8 0.7 6.2e-11 41.9 0.7 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p TPP_enzyme_C PF02775.21 EPA05125.1 - 6.8e-29 100.6 0.2 1.1e-28 99.9 0.2 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PFO_beta_C PF12367.8 EPA05125.1 - 4.8e-15 55.5 0.6 1.2e-13 51.0 0.6 2.4 1 1 0 1 1 1 1 Pyruvate ferredoxin oxidoreductase beta subunit C terminal Ribosomal_L27A PF00828.19 EPA05126.1 - 3.1e-15 57.0 0.1 4.5e-15 56.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ribosomal_L18 PF17135.4 EPA05126.1 - 0.068 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein 60S L18 and 50S L18e OTCace PF00185.24 EPA05127.1 - 1.2e-51 174.9 0.0 1.7e-51 174.4 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 EPA05127.1 - 1.6e-49 167.7 0.0 2.2e-49 167.3 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain TFIIB PF00382.19 EPA05128.1 - 3.4e-32 110.3 5.1 4.2e-16 58.7 0.2 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EPA05128.1 - 1.2e-10 40.8 1.2 1.9e-10 40.0 1.2 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_11 PF08279.12 EPA05128.1 - 0.0003 20.7 2.2 0.16 12.0 0.0 3.3 3 0 0 3 3 3 1 HTH domain Cyclin_C PF02984.19 EPA05128.1 - 0.0044 17.1 0.0 3.6 7.7 0.0 2.4 2 0 0 2 2 2 2 Cyclin, C-terminal domain HTH_AsnC-type PF13404.6 EPA05128.1 - 0.0053 16.6 0.1 0.28 11.1 0.1 2.5 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain Phage_terminase PF10668.9 EPA05128.1 - 0.01 15.8 0.2 4.5 7.4 0.0 3.3 3 0 0 3 3 3 0 Phage terminase small subunit HTH_23 PF13384.6 EPA05128.1 - 0.011 15.6 0.2 3.9 7.4 0.0 2.9 3 0 0 3 3 3 0 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EPA05128.1 - 0.011 15.3 2.6 0.99 9.1 0.1 2.9 3 0 0 3 3 3 0 Sigma-70, region 4 Sigma70_r4 PF04545.16 EPA05128.1 - 0.013 15.1 0.1 0.54 9.8 0.0 3.0 3 0 0 3 3 3 0 Sigma-70, region 4 Cyclin_N PF00134.23 EPA05128.1 - 0.018 14.8 0.2 0.27 11.0 0.1 2.1 2 0 0 2 2 2 0 Cyclin, N-terminal domain DZR PF12773.7 EPA05128.1 - 0.022 14.7 0.3 0.049 13.6 0.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon DUF294_C PF10335.9 EPA05128.1 - 0.027 14.3 0.4 5.1 6.9 0.0 2.3 2 0 0 2 2 2 0 Putative nucleotidyltransferase substrate binding domain RB_B PF01857.20 EPA05128.1 - 0.033 14.2 0.1 0.12 12.5 0.0 1.8 1 1 1 2 2 2 0 Retinoblastoma-associated protein B domain MarR PF01047.22 EPA05128.1 - 0.057 13.4 0.1 0.4 10.7 0.0 2.4 3 0 0 3 3 2 0 MarR family TPR_5 PF12688.7 EPA05128.1 - 0.067 13.4 0.2 0.17 12.1 0.1 1.7 1 1 0 1 1 1 0 Tetratrico peptide repeat HTH_24 PF13412.6 EPA05128.1 - 0.08 12.5 0.1 18 5.0 0.0 2.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HypA PF01155.19 EPA05128.1 - 0.15 12.1 0.7 0.36 10.9 0.1 1.9 2 0 0 2 2 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_2 PF13240.6 EPA05128.1 - 0.15 11.8 0.3 0.15 11.8 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain A2L_zn_ribbon PF08792.10 EPA05128.1 - 0.2 11.4 2.2 0.39 10.5 2.2 1.4 1 0 0 1 1 1 0 A2L zinc ribbon domain HemS PF05171.12 EPA05129.1 - 3e-07 30.4 0.1 3.5e-07 30.2 0.1 1.1 1 0 0 1 1 1 1 Haemin-degrading HemS.ChuX domain ChuX_HutX PF06228.13 EPA05129.1 - 6.7e-07 29.2 0.0 8.6e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Haem utilisation ChuX/HutX F420_ligase PF01996.16 EPA05130.1 - 3e-07 30.0 0.0 3.7e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase Ribosomal_L5e PF17144.4 EPA05131.1 - 1.8e-14 54.0 2.8 1.9e-11 44.2 1.0 2.7 1 1 1 2 2 2 2 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18p PF00861.22 EPA05131.1 - 0.012 16.0 0.2 0.016 15.5 0.2 1.2 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast 2-Hacid_dh_C PF02826.19 EPA05133.1 - 1.4e-60 203.7 0.1 2e-60 203.2 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EPA05133.1 - 3.6e-32 110.8 0.0 4.1e-32 110.6 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain IlvN PF07991.12 EPA05133.1 - 7.5e-07 28.9 0.6 1.4e-06 28.0 0.2 1.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 EPA05133.1 - 1.2e-06 28.7 0.3 2.7e-06 27.6 0.2 1.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EPA05133.1 - 0.00085 19.9 0.1 0.0035 17.9 0.1 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 EPA05133.1 - 0.057 13.5 0.3 0.1 12.7 0.3 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain EMC3_TMCO1 PF01956.16 EPA05134.1 - 7.6e-16 58.3 14.5 4.1e-15 55.9 14.5 1.8 1 1 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like DUF2208 PF09973.9 EPA05134.1 - 0.62 9.6 9.1 0.3 10.7 3.6 2.6 2 1 1 3 3 3 0 Predicted membrane protein (DUF2208) DUF4199 PF13858.6 EPA05134.1 - 6.2 7.2 9.4 7 7.0 7.1 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF4199) AAA_18 PF13238.6 EPA05135.1 - 3.6e-12 46.9 0.0 5.1e-12 46.5 0.0 1.2 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 EPA05135.1 - 1.4e-11 44.9 0.3 3.2e-10 40.4 0.3 2.1 1 1 0 1 1 1 1 Cytidylate kinase-like family AAA_17 PF13207.6 EPA05135.1 - 2.1e-09 37.9 0.0 3.8e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EPA05135.1 - 1.2e-07 31.7 0.2 8.2e-05 22.4 0.0 2.1 1 1 1 2 2 2 2 Cytidylate kinase ADK PF00406.22 EPA05135.1 - 2e-05 24.7 0.3 6.5e-05 23.1 0.0 1.9 2 1 0 2 2 2 1 Adenylate kinase SKI PF01202.22 EPA05135.1 - 3e-05 24.2 0.3 0.00076 19.6 0.3 2.2 1 1 0 1 1 1 1 Shikimate kinase AAA PF00004.29 EPA05135.1 - 6.5e-05 23.4 0.0 0.00011 22.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EPA05135.1 - 0.00031 20.7 0.0 0.0005 20.0 0.0 1.4 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_28 PF13521.6 EPA05135.1 - 0.00052 20.3 0.0 0.00094 19.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EPA05135.1 - 0.00067 19.8 0.1 0.0011 19.2 0.1 1.6 1 1 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 EPA05135.1 - 0.0019 18.5 0.1 0.0045 17.3 0.0 1.6 2 0 0 2 2 2 1 Hydin Adenylate kinase-like domain KTI12 PF08433.10 EPA05135.1 - 0.0032 17.0 0.1 0.011 15.2 0.1 1.8 1 1 0 1 1 1 1 Chromatin associated protein KTI12 dNK PF01712.19 EPA05135.1 - 0.0033 17.3 0.5 0.092 12.6 0.1 2.2 2 0 0 2 2 2 1 Deoxynucleoside kinase DUF3616 PF12275.8 EPA05135.1 - 0.0038 16.7 0.3 0.0061 16.0 0.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3616) RNA_helicase PF00910.22 EPA05135.1 - 0.005 17.2 0.0 0.01 16.2 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 EPA05135.1 - 0.0075 16.3 0.2 0.055 13.5 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EPA05135.1 - 0.0078 15.9 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF4960 PF16324.5 EPA05135.1 - 0.0091 15.6 0.7 0.011 15.3 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4960) RTX_C PF08339.10 EPA05135.1 - 0.016 15.3 0.6 0.02 15.0 0.6 1.2 1 0 0 1 1 1 0 RTX C-terminal domain RuvB_N PF05496.12 EPA05135.1 - 0.016 14.9 0.1 0.024 14.4 0.1 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EPA05135.1 - 0.019 15.4 0.0 0.019 15.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EPA05135.1 - 0.03 14.6 0.0 0.065 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EPA05135.1 - 0.08 12.8 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 NTPase Nif11 PF07862.11 EPA05135.1 - 0.092 13.1 1.1 0.32 11.3 0.0 2.4 3 0 0 3 3 2 0 Nif11 domain Guanylate_kin PF00625.21 EPA05135.1 - 0.12 12.1 1.3 2.7 7.6 0.0 2.4 2 1 0 2 2 2 0 Guanylate kinase Ribosomal_60s PF00428.19 EPA05136.1 - 1.8 9.2 10.6 0.21 12.2 2.1 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Aft1_HRR PF11787.8 EPA05136.1 - 3.8 8.7 6.8 4.3 8.6 1.8 2.3 2 0 0 2 2 2 0 Aft1 HRR domain SKG6 PF08693.10 EPA05137.1 - 0.094 12.1 0.3 0.094 12.1 0.3 2.4 2 1 0 2 2 2 0 Transmembrane alpha-helix domain Tubulin PF00091.25 EPA05138.1 - 0.02 15.1 0.1 0.052 13.7 0.0 1.8 2 0 0 2 2 2 0 Tubulin/FtsZ family, GTPase domain DUF3782 PF12644.7 EPA05138.1 - 0.28 11.4 1.3 14 5.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3782) DASH_Dam1 PF08653.10 EPA05139.1 - 0.045 13.5 1.0 6.2 6.7 0.2 2.2 2 0 0 2 2 2 0 DASH complex subunit Dam1 DUF5082 PF16888.5 EPA05139.1 - 0.053 13.8 0.8 0.25 11.6 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) TRPM_tetra PF16519.5 EPA05139.1 - 0.065 13.3 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 Tetramerisation domain of TRPM ILVD_EDD PF00920.21 EPA05142.1 - 3.7e-41 141.3 0.0 4.1e-41 141.2 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family eRF1_1 PF03463.15 EPA05145.1 - 2.9e-20 72.6 0.3 3.8e-20 72.2 0.3 1.1 1 0 0 1 1 1 1 eRF1 domain 1 UPF0047 PF01894.17 EPA05146.1 - 1.3e-21 76.9 0.1 1.6e-21 76.6 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 Peptidase_M50 PF02163.22 EPA05148.1 - 2.5e-19 69.5 0.6 2.6e-17 62.9 0.6 2.3 1 1 0 1 1 1 1 Peptidase family M50 PDZ_2 PF13180.6 EPA05148.1 - 3.6e-09 36.8 0.0 6.3e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EPA05148.1 - 1e-07 31.7 0.0 1.7e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EPA05148.1 - 0.0029 17.9 0.1 0.0056 17.0 0.1 1.4 1 0 0 1 1 1 1 PDZ domain ATP_bind_3 PF01171.20 EPA05149.1 - 4.3e-17 62.4 0.0 6.6e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.16 EPA05149.1 - 1.2e-05 24.3 0.0 1.6e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.13 EPA05149.1 - 0.0065 16.0 0.2 0.015 14.8 0.2 1.8 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 EPA05149.1 - 0.064 13.3 0.0 0.076 13.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family HHH_5 PF14520.6 EPA05151.1 - 5e-13 49.4 0.8 7.6e-13 48.9 0.8 1.2 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 EPA05151.1 - 1.2e-07 31.4 0.0 3.8e-07 29.8 0.0 1.7 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_2 PF12826.7 EPA05151.1 - 1.9e-06 27.9 0.1 7.1e-06 26.0 0.0 1.9 1 1 1 2 2 2 1 Helix-hairpin-helix motif DUF4332 PF14229.6 EPA05151.1 - 0.0014 18.8 0.0 0.0028 17.9 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4332) HHH_8 PF14716.6 EPA05151.1 - 0.0015 18.8 0.2 0.096 13.1 0.3 2.3 1 1 1 2 2 2 2 Helix-hairpin-helix domain RNA_pol_A_CTD PF03118.15 EPA05151.1 - 0.0028 17.4 1.3 0.0062 16.3 0.1 2.1 3 0 0 3 3 3 1 Bacterial RNA polymerase, alpha chain C terminal domain HHH PF00633.23 EPA05151.1 - 0.0034 17.2 0.1 0.077 12.9 0.0 3.0 3 0 0 3 3 3 1 Helix-hairpin-helix motif Cdd1 PF11731.8 EPA05151.1 - 0.038 14.2 0.1 0.24 11.6 0.0 2.0 1 1 1 2 2 2 0 Pathogenicity locus TfoX_C PF04994.13 EPA05151.1 - 0.12 12.5 0.1 0.34 11.0 0.1 2.0 1 1 0 1 1 1 0 TfoX C-terminal domain DsbD PF02683.15 EPA05152.1 - 5.4e-07 29.7 8.8 5.4e-07 29.7 8.8 1.9 1 1 1 2 2 2 1 Cytochrome C biogenesis protein transmembrane region EamA PF00892.20 EPA05152.1 - 0.51 10.5 18.7 1.1 9.4 6.5 2.5 2 1 0 2 2 2 0 EamA-like transporter family UNC-50 PF05216.13 EPA05152.1 - 1 8.9 7.1 1.4 8.4 7.1 1.2 1 0 0 1 1 1 0 UNC-50 family Ninjurin PF04923.12 EPA05152.1 - 1.1 9.3 5.7 3.3 7.7 2.3 2.3 2 0 0 2 2 2 0 Ninjurin Phage_holin_3_6 PF07332.11 EPA05152.1 - 3.2 7.8 16.8 0.17 12.0 4.4 2.4 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III HTH_17 PF12728.7 EPA05153.1 - 0.00056 20.0 1.4 0.046 13.9 0.0 3.2 4 0 0 4 4 4 1 Helix-turn-helix domain HTH_11 PF08279.12 EPA05153.1 - 0.00068 19.5 0.0 0.0016 18.4 0.0 1.6 1 0 0 1 1 1 1 HTH domain zf-Di19 PF05605.12 EPA05153.1 - 0.0012 19.0 0.5 0.058 13.7 0.0 2.7 3 0 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding HTH_36 PF13730.6 EPA05153.1 - 0.022 14.7 0.3 0.056 13.4 0.3 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain DUF3449 PF11931.8 EPA05153.1 - 0.053 13.3 0.6 0.18 11.6 0.3 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF3449) FUR PF01475.19 EPA05153.1 - 0.068 13.3 2.2 4.2 7.5 0.1 2.7 2 2 1 3 3 3 0 Ferric uptake regulator family Sgf11 PF08209.11 EPA05153.1 - 0.09 12.4 1.6 0.13 11.8 0.0 2.1 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) HTH_22 PF13309.6 EPA05153.1 - 0.13 12.3 0.2 0.29 11.2 0.2 1.6 1 0 0 1 1 1 0 HTH domain zf-BED PF02892.15 EPA05153.1 - 2.4 8.3 4.7 4.8 7.3 1.1 3.0 3 1 0 3 3 3 0 BED zinc finger Pterin_bind PF00809.22 EPA05154.1 - 2e-37 129.2 0.1 4.5e-37 128.0 0.1 1.5 1 1 0 1 1 1 1 Pterin binding enzyme Spermine_synth PF01564.17 EPA05154.1 - 0.076 12.4 0.1 0.12 11.7 0.1 1.5 1 0 0 1 1 1 0 Spermine/spermidine synthase domain Pterin_bind PF00809.22 EPA05155.1 - 8.5e-39 133.7 0.1 1.8e-38 132.6 0.1 1.5 1 1 0 1 1 1 1 Pterin binding enzyme Spermine_synth PF01564.17 EPA05155.1 - 0.065 12.6 0.1 0.1 12.0 0.1 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase domain Radical_SAM PF04055.21 EPA05156.1 - 3.3e-15 56.9 0.2 3.3e-15 56.9 0.2 2.5 3 0 0 3 3 3 1 Radical SAM superfamily Fer4_12 PF13353.6 EPA05156.1 - 1.1e-06 29.0 0.0 3.2e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EPA05156.1 - 1.7e-06 28.1 0.0 1.7e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain Asn_synthase PF00733.21 EPA05157.1 - 2.8e-28 99.6 0.0 3.8e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.17 EPA05157.1 - 6e-07 28.8 0.0 9.5e-07 28.2 0.0 1.3 1 0 0 1 1 1 1 NAD synthase QueC PF06508.13 EPA05157.1 - 0.00048 19.7 0.0 0.0008 19.0 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EPA05157.1 - 0.00098 18.0 0.0 0.0015 17.4 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase ATP_bind_3 PF01171.20 EPA05157.1 - 0.0031 17.3 0.2 0.0073 16.1 0.0 1.7 2 0 0 2 2 2 1 PP-loop family UDPG_MGDP_dh_N PF03721.14 EPA05158.1 - 6.1e-38 130.3 0.0 1.5e-37 129.0 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 EPA05158.1 - 1.9e-22 79.2 0.1 4.5e-22 78.1 0.1 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 EPA05158.1 - 6e-22 78.0 0.0 2.1e-21 76.3 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 2-Hacid_dh_C PF02826.19 EPA05158.1 - 9e-06 25.2 0.0 0.83 9.0 0.0 3.4 3 0 0 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EPA05158.1 - 1.3e-05 25.4 0.0 9.6e-05 22.6 0.0 2.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase DpaA_N PF16924.5 EPA05158.1 - 4.1e-05 23.6 0.7 1.2 9.3 0.0 3.6 4 0 0 4 4 4 2 Dipicolinate synthase subunit A N-terminal domain NAD_Gly3P_dh_N PF01210.23 EPA05158.1 - 0.0094 15.9 0.0 0.26 11.2 0.0 2.6 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 EPA05158.1 - 0.044 13.7 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_11 PF14833.6 EPA05158.1 - 0.069 13.4 0.2 0.16 12.2 0.2 1.6 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase ThiF PF00899.21 EPA05158.1 - 0.085 12.2 0.1 0.17 11.2 0.1 1.5 1 1 0 1 1 1 0 ThiF family PA28_beta PF02252.18 EPA05158.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit F420_oxidored PF03807.17 EPA05158.1 - 0.16 12.6 1.1 28 5.4 0.0 3.2 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent TrmB PF01978.19 EPA05159.1 - 4.4e-21 74.5 0.0 1.4e-20 72.9 0.0 1.9 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 EPA05159.1 - 1.2e-07 31.1 0.0 1.5e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB HTH_IclR PF09339.10 EPA05159.1 - 3.8e-05 23.4 0.0 0.0002 21.1 0.0 2.1 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR PF01047.22 EPA05159.1 - 0.0012 18.7 0.0 0.0042 17.0 0.0 1.9 1 1 1 2 2 2 1 MarR family HTH_24 PF13412.6 EPA05159.1 - 0.0063 16.0 0.0 0.016 14.7 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Penicillinase_R PF03965.16 EPA05159.1 - 0.0076 16.6 0.1 0.042 14.2 0.0 2.0 2 0 0 2 2 2 1 Penicillinase repressor HTH_27 PF13463.6 EPA05159.1 - 0.0089 16.5 0.0 0.022 15.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix DNA-binding domain Rrf2 PF02082.20 EPA05159.1 - 0.053 13.9 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 Transcriptional regulator PLDc_2 PF13091.6 EPA05159.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 PLD-like domain PadR PF03551.14 EPA05159.1 - 0.13 12.3 0.0 0.31 11.0 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family MarR_2 PF12802.7 EPA05159.1 - 0.18 11.7 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 MarR family Fe_dep_repress PF01325.19 EPA05160.1 - 1.8e-11 44.1 0.1 2.3e-11 43.7 0.1 1.1 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain MarR PF01047.22 EPA05160.1 - 0.0054 16.6 0.0 0.0066 16.3 0.0 1.1 1 0 0 1 1 1 1 MarR family NLPC_P60 PF00877.19 EPA05160.1 - 0.025 14.6 0.0 0.028 14.5 0.0 1.1 1 0 0 1 1 1 0 NlpC/P60 family HTH_37 PF13744.6 EPA05160.1 - 0.031 14.2 0.0 0.038 14.0 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_27 PF13463.6 EPA05160.1 - 0.048 14.2 0.0 0.063 13.8 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain MarR_2 PF12802.7 EPA05160.1 - 0.051 13.5 0.0 0.063 13.2 0.0 1.2 1 0 0 1 1 1 0 MarR family Methyltransf_21 PF05050.12 EPA05162.1 - 5.1e-21 75.4 0.7 7.1e-21 75.0 0.7 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Met_10 PF02475.16 EPA05162.1 - 8.9e-10 38.6 0.5 1.9e-09 37.5 0.3 1.5 1 1 0 1 1 1 1 Met-10+ like-protein V_cholerae_RfbT PF05575.11 EPA05162.1 - 6e-07 29.0 3.6 8.1e-07 28.6 3.6 1.2 1 0 0 1 1 1 1 Vibrio cholerae RfbT protein PCMT PF01135.19 EPA05162.1 - 2.1e-05 24.4 0.0 3.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EPA05162.1 - 6.2e-05 22.8 0.2 9.1e-05 22.3 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EPA05162.1 - 0.00046 20.1 0.6 0.13 12.2 0.1 2.4 1 1 1 2 2 2 2 Methyltransferase domain MTS PF05175.14 EPA05162.1 - 0.0051 16.4 0.0 0.0083 15.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 EPA05162.1 - 0.0057 16.8 0.0 0.0077 16.4 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 EPA05162.1 - 0.0068 17.1 0.0 0.02 15.6 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain PrmA PF06325.13 EPA05162.1 - 0.0098 15.3 0.3 0.015 14.7 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltr_RsmB-F PF01189.17 EPA05162.1 - 0.057 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Epimerase PF01370.21 EPA05164.1 - 5.7e-44 150.4 0.0 6.2e-44 150.3 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EPA05164.1 - 7.5e-38 130.8 0.1 8.2e-38 130.6 0.1 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EPA05164.1 - 2.6e-26 92.3 0.2 3.4e-26 91.9 0.2 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EPA05164.1 - 5.2e-22 78.3 0.0 6.1e-22 78.0 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EPA05164.1 - 1.2e-16 60.8 0.1 8.7e-16 57.9 0.1 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EPA05164.1 - 2e-15 56.7 0.2 2.8e-10 39.8 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 EPA05164.1 - 2.3e-08 34.1 0.0 2.8e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EPA05164.1 - 5.6e-08 32.9 0.1 1.6e-07 31.4 0.1 1.6 1 1 0 1 1 1 1 KR domain NmrA PF05368.13 EPA05164.1 - 2.3e-06 27.3 0.1 3.1e-06 26.9 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EPA05164.1 - 0.00021 20.8 0.1 0.00052 19.5 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase Shikimate_DH PF01488.20 EPA05164.1 - 0.00039 20.5 0.0 0.00082 19.5 0.0 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EPA05164.1 - 0.00083 19.6 0.0 0.0015 18.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EPA05164.1 - 0.025 14.8 0.0 0.045 14.0 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain AbiGi PF10899.8 EPA05164.1 - 0.031 14.1 0.3 0.039 13.8 0.3 1.1 1 0 0 1 1 1 0 Putative abortive phage resistance protein AbiGi, antitoxin Glyco_transf_4 PF13439.6 EPA05165.1 - 1.5e-09 38.1 0.1 4.2e-08 33.4 0.1 2.1 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_2 PF13477.6 EPA05165.1 - 1.1e-06 28.8 0.4 0.00012 22.1 0.5 2.4 1 1 1 2 2 2 1 Glycosyl transferase 4-like Glyco_trans_4_4 PF13579.6 EPA05165.1 - 0.00011 22.6 0.0 0.00025 21.5 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain PIGA PF08288.12 EPA05165.1 - 0.0007 20.1 0.5 0.007 16.9 0.1 2.2 1 1 1 2 2 2 1 PIGA (GPI anchor biosynthesis) Helicase_IV_N PF12462.8 EPA05165.1 - 0.01 15.8 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 DNA helicase IV / RNA helicase N terminal Glycos_transf_1 PF00534.20 EPA05165.1 - 0.026 14.0 0.2 5.9 6.4 0.0 2.5 2 1 1 3 3 3 0 Glycosyl transferases group 1 S-AdoMet_synt_C PF02773.16 EPA05166.1 - 7.7e-70 233.2 0.1 7.8e-69 230.0 0.0 1.9 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EPA05166.1 - 5.3e-34 117.1 0.4 9.4e-34 116.2 0.4 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain Mt_ATP-synt_B PF05405.14 EPA05166.1 - 0.064 12.9 0.3 0.098 12.3 0.3 1.2 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Epimerase PF01370.21 EPA05167.1 - 8e-14 51.7 0.0 7.6e-13 48.5 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EPA05167.1 - 1.6e-11 44.4 0.0 2.3e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EPA05167.1 - 5.2e-10 38.8 1.4 6.1e-07 28.7 0.3 2.4 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EPA05167.1 - 3.7e-06 26.3 0.0 0.07 12.2 0.0 2.3 2 1 0 2 2 2 2 RmlD substrate binding domain NAD_binding_4 PF07993.12 EPA05167.1 - 6.6e-05 22.2 0.2 0.047 12.9 0.1 2.8 1 1 1 3 3 3 2 Male sterility protein Shikimate_DH PF01488.20 EPA05167.1 - 0.014 15.5 0.2 0.029 14.4 0.2 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase PAC2 PF09754.9 EPA05167.1 - 0.06 13.3 0.0 0.08 12.9 0.0 1.3 1 0 0 1 1 1 0 PAC2 family Phage_spike_2 PF18781.1 EPA05167.1 - 0.11 12.6 1.0 0.93 9.6 0.0 2.9 3 1 0 3 3 3 0 Phage spike trimer CbiD PF01888.17 EPA05168.1 - 5.2e-77 258.5 1.2 5.9e-77 258.4 1.2 1.0 1 0 0 1 1 1 1 CbiD DUF3042 PF11240.8 EPA05168.1 - 0.017 15.2 0.7 0.047 13.7 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) TAL_FSA PF00923.19 EPA05169.1 - 1.3e-09 37.8 0.0 1.5e-09 37.7 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Transketolase_C PF02780.20 EPA05170.1 - 5.5e-31 107.0 0.0 7.4e-31 106.6 0.0 1.2 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 EPA05170.1 - 1.2e-13 51.1 0.0 1.8e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain PFOR_II PF17147.4 EPA05170.1 - 0.0023 18.2 0.0 0.0042 17.4 0.0 1.4 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II PRA-CH PF01502.18 EPA05171.1 - 4.4e-33 112.9 0.1 5.4e-33 112.6 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase His_biosynth PF00977.21 EPA05172.1 - 2.6e-59 200.5 0.7 3.2e-59 200.2 0.7 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Dus PF01207.17 EPA05172.1 - 5.6e-09 35.5 0.3 0.0006 19.0 0.1 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) NMO PF03060.15 EPA05172.1 - 2.3e-05 23.9 0.3 0.097 12.0 0.0 2.1 2 0 0 2 2 2 2 Nitronate monooxygenase TMP-TENI PF02581.17 EPA05172.1 - 6.6e-05 22.3 0.1 0.013 14.9 0.0 2.2 2 0 0 2 2 2 2 Thiamine monophosphate synthase DHO_dh PF01180.21 EPA05172.1 - 0.00015 21.1 0.1 0.012 14.8 0.0 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase ThiG PF05690.14 EPA05172.1 - 0.00016 21.1 0.4 0.1 11.9 0.1 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 EPA05172.1 - 0.0043 16.5 0.1 0.53 9.7 0.1 2.3 2 0 0 2 2 2 1 Glycerol-3-phosphate responsive antiterminator Trp_syntA PF00290.20 EPA05172.1 - 0.026 13.4 0.3 0.045 12.6 0.1 1.5 2 0 0 2 2 2 0 Tryptophan synthase alpha chain PcrB PF01884.17 EPA05172.1 - 0.058 12.8 0.8 0.17 11.3 0.1 2.0 2 1 0 2 2 2 0 PcrB family PALP PF00291.25 EPA05175.1 - 4.5e-49 167.4 0.6 5.1e-49 167.3 0.6 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACP_syn_III_C PF08541.10 EPA05175.1 - 0.028 14.6 0.0 0.087 13.0 0.0 1.9 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Peptidase_C14 PF00656.22 EPA05175.1 - 0.076 13.0 0.0 0.29 11.0 0.0 1.8 2 0 0 2 2 2 0 Caspase domain ThiF PF00899.21 EPA05176.1 - 2.7e-64 216.9 0.4 3.7e-64 216.4 0.4 1.1 1 0 0 1 1 1 1 ThiF family ThiS PF02597.20 EPA05176.1 - 2.2e-08 34.6 0.0 7.3e-08 32.9 0.0 1.9 1 0 0 1 1 1 1 ThiS family Sacchrp_dh_NADP PF03435.18 EPA05176.1 - 0.00034 20.9 2.6 0.0016 18.7 2.2 2.2 1 1 1 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EPA05176.1 - 0.019 15.0 0.1 0.048 13.7 0.1 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EPA05176.1 - 0.053 12.9 0.0 0.092 12.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain C1_2 PF03107.16 EPA05177.1 - 0.014 15.7 1.9 0.019 15.2 1.9 1.2 1 0 0 1 1 1 0 C1 domain zf-C2H2_11 PF16622.5 EPA05177.1 - 0.27 11.0 0.4 0.27 11.0 0.4 1.5 2 0 0 2 2 2 0 zinc-finger C2H2-type bact-PGI_C PF10432.9 EPA05179.1 - 1.2e-32 113.0 0.1 1.8e-32 112.5 0.1 1.3 1 0 0 1 1 1 1 Bacterial phospho-glucose isomerase C-terminal SIS domain SIS PF01380.22 EPA05179.1 - 0.00026 20.9 0.1 0.00051 19.9 0.1 1.5 1 0 0 1 1 1 1 SIS domain UbiA PF01040.18 EPA05180.1 - 0.1 11.9 0.0 0.11 11.7 0.0 1.0 1 0 0 1 1 1 0 UbiA prenyltransferase family AIPR PF10592.9 EPA05182.1 - 7.5e-63 212.9 6.1 7.5e-63 212.9 6.1 1.3 1 1 0 1 1 1 1 AIPR protein RGS PF00615.19 EPA05182.1 - 0.05 13.9 0.6 0.21 11.9 0.1 2.3 2 1 0 2 2 2 0 Regulator of G protein signaling domain HTH_45 PF14947.6 EPA05183.1 - 3.4e-15 55.8 0.4 3.9e-15 55.6 0.4 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 EPA05183.1 - 0.00024 20.9 0.2 0.00024 20.9 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) PadR PF03551.14 EPA05183.1 - 0.0026 17.7 0.1 0.0034 17.3 0.1 1.2 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_34 PF13601.6 EPA05183.1 - 0.0029 17.8 0.3 0.0037 17.4 0.3 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain RNA_pol_Rpc34 PF05158.12 EPA05183.1 - 0.0041 16.5 0.0 0.0049 16.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit DUF505 PF04458.12 EPA05183.1 - 0.016 13.6 0.1 0.016 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF505) Rrf2 PF02082.20 EPA05183.1 - 0.026 14.9 0.1 0.05 13.9 0.1 1.5 2 0 0 2 2 2 0 Transcriptional regulator PilN PF05137.13 EPA05183.1 - 0.062 13.4 0.1 0.084 13.0 0.1 1.5 1 1 0 1 1 1 0 Fimbrial assembly protein (PilN) TrmB PF01978.19 EPA05183.1 - 0.071 13.0 0.0 0.094 12.6 0.0 1.4 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Mrr_N PF14338.6 EPA05183.1 - 0.072 13.2 0.0 0.092 12.9 0.0 1.4 1 1 0 1 1 1 0 Mrr N-terminal domain MarR PF01047.22 EPA05183.1 - 0.12 12.4 0.1 0.21 11.5 0.1 1.4 2 0 0 2 2 2 0 MarR family Mannosyl_trans2 PF04188.13 EPA05183.1 - 0.13 11.5 0.0 0.14 11.5 0.0 1.0 1 0 0 1 1 1 0 Mannosyltransferase (PIG-V) FAM221 PF14753.6 EPA05184.1 - 0.0006 19.4 1.2 0.00077 19.1 1.2 1.2 1 0 0 1 1 1 1 Protein FAM221A/B RNaseH_like PF04308.12 EPA05184.1 - 0.088 12.7 0.0 0.16 11.9 0.0 1.4 1 1 0 1 1 1 0 Ribonuclease H-like DUF4428 PF14471.6 EPA05185.1 - 0.0066 16.3 2.9 0.014 15.3 2.9 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4428) zf-RRN7 PF11781.8 EPA05185.1 - 0.016 14.8 0.3 4.2 7.1 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Vps36-NZF-N PF16988.5 EPA05185.1 - 0.064 12.7 1.3 0.087 12.2 1.3 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain PDH PF02153.17 EPA05186.1 - 1.8e-24 86.2 0.3 2.1e-24 86.0 0.3 1.1 1 0 0 1 1 1 1 Prephenate dehydrogenase 2-Hacid_dh_C PF02826.19 EPA05186.1 - 4.8e-06 26.0 0.1 9.2e-06 25.1 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EPA05186.1 - 1.6e-05 25.1 0.2 6e-05 23.3 0.0 1.9 2 1 1 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EPA05186.1 - 0.0001 22.8 0.9 0.0012 19.3 0.0 3.1 3 2 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 EPA05186.1 - 0.00034 20.6 0.3 0.0011 18.9 0.0 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EPA05186.1 - 0.01 15.8 0.8 9 6.2 0.0 3.1 2 1 1 3 3 3 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NmrA PF05368.13 EPA05186.1 - 0.03 13.9 0.8 1.2 8.6 0.1 2.6 3 0 0 3 3 3 0 NmrA-like family DpaA_N PF16924.5 EPA05186.1 - 0.037 14.1 0.1 0.17 11.9 0.0 2.2 2 2 0 2 2 2 0 Dipicolinate synthase subunit A N-terminal domain DUF1392 PF07154.11 EPA05186.1 - 0.057 13.5 0.1 0.16 12.1 0.0 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1392) Semialdhyde_dh PF01118.24 EPA05186.1 - 0.059 13.8 0.0 4.8 7.6 0.0 2.9 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain IlvN PF07991.12 EPA05186.1 - 0.063 12.9 0.1 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Epimerase PF01370.21 EPA05186.1 - 0.13 11.7 0.0 0.35 10.3 0.0 1.8 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family ThiC_Rad_SAM PF01964.18 EPA05187.1 - 5.5e-172 572.3 0.4 6.3e-172 572.1 0.4 1.0 1 0 0 1 1 1 1 Radical SAM ThiC family NUDIX PF00293.28 EPA05188.1 - 3.4e-12 46.5 0.0 3.7e-12 46.4 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 EPA05188.1 - 0.00014 21.8 0.0 0.00019 21.4 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Protamine_like PF06382.11 EPA05188.1 - 0.025 14.8 0.1 0.033 14.4 0.1 1.2 1 0 0 1 1 1 0 Protamine and protamine like Aminotran_1_2 PF00155.21 EPA05189.1 - 5e-62 210.2 0.0 7.2e-62 209.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II CM_2 PF01817.21 EPA05189.1 - 5.7e-11 42.6 1.0 1.8e-10 41.0 1.0 1.9 1 0 0 1 1 1 1 Chorismate mutase type II Aminotran_5 PF00266.19 EPA05189.1 - 2.7e-06 26.6 0.0 4.8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EPA05189.1 - 4.7e-05 22.1 0.0 7.3e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EPA05189.1 - 0.00019 20.9 0.0 0.00028 20.3 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Alliinase_C PF04864.13 EPA05189.1 - 0.00039 19.4 0.8 0.0062 15.5 0.1 2.7 3 0 0 3 3 3 1 Allinase LppX_LprAFG PF07161.13 EPA05189.1 - 0.011 15.6 0.1 0.045 13.6 0.0 1.9 2 0 0 2 2 2 0 LppX_LprAFG lipoprotein SPATA1_C PF15743.5 EPA05189.1 - 0.037 14.1 1.2 0.12 12.5 1.2 1.9 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus Chorismate_synt PF01264.21 EPA05190.1 - 1.5e-64 217.8 0.3 1.7e-64 217.6 0.3 1.0 1 0 0 1 1 1 1 Chorismate synthase TMEM214 PF10151.9 EPA05191.1 - 0.016 13.7 0.1 0.017 13.6 0.1 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Type_ISP_C PF18135.1 EPA05191.1 - 0.052 12.6 0.3 0.056 12.4 0.3 1.0 1 0 0 1 1 1 0 Type ISP C-terminal specificity domain TusA PF01206.17 EPA05193.1 - 4.7e-22 77.6 0.0 5.2e-22 77.4 0.0 1.0 1 0 0 1 1 1 1 Sulfurtransferase TusA PALP PF00291.25 EPA05194.1 - 2e-64 217.8 0.0 2.9e-64 217.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Trypsin_2 PF13365.6 EPA05195.1 - 1.7e-33 116.6 0.3 2.9e-33 115.9 0.3 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 EPA05195.1 - 1.1e-14 54.5 0.2 1.1e-14 54.5 0.2 2.0 2 1 1 3 3 3 1 PDZ domain Trypsin PF00089.26 EPA05195.1 - 1.6e-14 54.3 0.3 3e-14 53.3 0.3 1.5 1 1 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 EPA05195.1 - 2.6e-05 24.0 1.5 0.023 14.5 0.1 3.2 3 0 0 3 3 3 2 PDZ domain PDZ PF00595.24 EPA05195.1 - 0.0013 19.0 2.6 3.1 8.2 1.6 3.7 2 1 0 2 2 2 1 PDZ domain Peptidase_S29 PF02907.15 EPA05195.1 - 0.0091 15.7 0.0 0.028 14.2 0.0 1.9 1 0 0 1 1 1 1 Hepatitis C virus NS3 protease Peptidase_S46 PF10459.9 EPA05195.1 - 0.079 11.6 0.8 0.14 10.8 0.8 1.3 1 0 0 1 1 1 0 Peptidase S46 CbiA PF01656.23 EPA05196.1 - 5.7e-19 68.4 0.0 7.6e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.6 EPA05196.1 - 1.4e-13 51.2 0.5 3.6e-07 30.2 0.0 2.1 1 1 1 2 2 2 2 AAA domain CTP_synth_N PF06418.14 EPA05196.1 - 0.0063 15.9 0.2 0.015 14.6 0.0 1.6 2 0 0 2 2 2 1 CTP synthase N-terminus ParA PF10609.9 EPA05196.1 - 0.047 13.1 0.3 0.26 10.7 0.0 1.9 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 EPA05196.1 - 0.11 12.0 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsQ Roc PF08477.13 EPA05196.1 - 0.11 12.7 0.0 32 4.8 0.0 2.6 1 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 EPA05196.1 - 0.13 12.0 0.2 0.54 10.0 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein STT3 PF02516.14 EPA05197.1 - 5.2e-35 121.3 30.5 8.2e-35 120.7 30.5 1.4 1 0 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit Dpy19 PF10034.9 EPA05197.1 - 0.00083 17.7 0.3 0.00083 17.7 0.3 2.5 2 1 0 2 2 2 1 Q-cell neuroblast polarisation EIF_2_alpha PF07541.12 EPA05198.1 - 1.1e-18 67.3 0.6 1.1e-18 67.3 0.6 1.9 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EPA05198.1 - 1.6e-12 47.6 0.2 8.3e-12 45.3 0.1 2.2 2 0 0 2 2 2 1 S1 RNA binding domain EXOSC1 PF10447.9 EPA05198.1 - 0.023 15.3 0.2 0.079 13.6 0.1 2.1 2 1 0 2 2 2 0 Exosome component EXOSC1/CSL4 CobA_CobO_BtuR PF02572.15 EPA05199.1 - 2.8e-60 203.5 0.4 3.1e-60 203.3 0.4 1.0 1 0 0 1 1 1 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP AAA_14 PF13173.6 EPA05199.1 - 0.0077 16.3 0.4 0.012 15.6 0.1 1.5 2 0 0 2 2 2 1 AAA domain ETRAMP PF09716.10 EPA05203.1 - 0.16 12.1 0.2 0.16 12.1 0.2 2.5 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) TrkH PF02386.16 EPA05204.1 - 2.7e-15 55.8 30.4 5.7e-09 35.0 10.2 3.2 1 1 1 2 2 2 2 Cation transport protein DUF2723 PF11028.8 EPA05204.1 - 0.01 15.8 4.6 0.012 15.6 2.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2723) PIRT PF15099.6 EPA05204.1 - 8 6.0 8.8 3.6 7.2 1.9 2.8 1 1 1 2 2 2 0 Phosphoinositide-interacting protein family Copper-bind PF00127.20 EPA05206.1 - 2.9e-10 40.5 0.1 4.5e-10 39.8 0.1 1.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 EPA05206.1 - 3.3e-06 27.2 1.1 0.00025 21.1 0.3 2.2 1 1 1 2 2 2 2 Cupredoxin-like domain SoxE PF06525.11 EPA05206.1 - 8.5e-05 22.1 0.1 0.00013 21.5 0.1 1.3 1 1 0 1 1 1 1 Sulfocyanin (SoxE) domain PP-binding PF00550.25 EPA05207.1 - 1.3e-05 25.5 0.0 2.3e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 Phosphopantetheine attachment site Acid_PPase PF12689.7 EPA05208.1 - 1.6e-06 28.0 0.3 0.0013 18.7 0.1 2.5 2 0 0 2 2 2 2 Acid Phosphatase NIF PF03031.18 EPA05208.1 - 3.7e-05 23.5 0.0 0.0001 22.1 0.0 1.8 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Methyltransf_3 PF01596.17 EPA05208.1 - 0.036 13.2 0.0 0.22 10.6 0.1 2.1 2 0 0 2 2 2 0 O-methyltransferase Polysacc_synt_3 PF13440.6 EPA05209.1 - 0.00033 20.0 30.7 0.035 13.3 18.1 3.2 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein Polysacc_synt PF01943.17 EPA05209.1 - 0.003 17.0 48.7 0.072 12.5 32.6 3.4 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.6 EPA05209.1 - 4 7.5 47.7 0.23 11.5 6.8 3.8 2 1 2 4 4 4 0 Polysaccharide biosynthesis C-terminal domain Glyco_trans_1_2 PF13524.6 EPA05210.1 - 0.00021 21.6 0.0 0.00041 20.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 HTH_11 PF08279.12 EPA05211.1 - 0.0002 21.3 0.1 0.00062 19.7 0.1 1.8 1 0 0 1 1 1 1 HTH domain HTH_30 PF13556.6 EPA05211.1 - 0.025 14.4 0.0 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 PucR C-terminal helix-turn-helix domain bact-PGI_C PF10432.9 EPA05212.1 - 1.2e-36 126.1 0.0 2.5e-36 125.0 0.0 1.5 2 0 0 2 2 2 1 Bacterial phospho-glucose isomerase C-terminal SIS domain SIS PF01380.22 EPA05212.1 - 2.1e-09 37.3 0.3 5.3e-09 36.0 0.1 1.8 2 0 0 2 2 2 1 SIS domain CTP_transf_3 PF02348.19 EPA05213.1 - 1.6e-31 109.9 2.3 2e-31 109.6 2.3 1.0 1 0 0 1 1 1 1 Cytidylyltransferase B3 PF02362.21 EPA05214.1 - 0.012 15.5 0.1 0.034 14.0 0.0 1.7 1 1 0 1 1 1 0 B3 DNA binding domain Pox_TAA1 PF03295.14 EPA05214.1 - 0.21 11.5 0.8 4.7 7.2 0.0 3.0 3 0 0 3 3 3 0 Poxvirus trans-activator protein A1 C-terminal Epimerase PF01370.21 EPA05215.1 - 3.1e-52 177.5 0.0 3.7e-52 177.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EPA05215.1 - 2.3e-51 175.2 0.0 3.4e-51 174.6 0.0 1.2 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EPA05215.1 - 1e-21 77.4 0.1 8.5e-21 74.3 0.1 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EPA05215.1 - 5.6e-20 71.5 0.1 7.6e-20 71.0 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EPA05215.1 - 1.4e-17 63.8 0.0 1.8e-17 63.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EPA05215.1 - 2.4e-08 33.4 0.0 3.6e-06 26.3 0.0 2.6 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.25 EPA05215.1 - 5.8e-06 25.9 0.0 0.00087 18.8 0.0 2.4 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 EPA05215.1 - 6.4e-06 26.2 0.0 1.8e-05 24.7 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EPA05215.1 - 4.4e-05 23.2 0.1 9e-05 22.1 0.0 1.5 2 0 0 2 2 2 1 NmrA-like family KR PF08659.10 EPA05215.1 - 0.00034 20.6 0.0 0.00075 19.5 0.0 1.6 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EPA05215.1 - 0.076 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GMP_synt_C PF00958.22 EPA05216.1 - 2.6e-35 120.4 0.0 5.7e-35 119.3 0.0 1.6 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 EPA05216.1 - 3.5e-15 56.3 0.0 6e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 EPA05216.1 - 3.8e-12 45.8 0.1 4.8e-06 25.9 0.0 2.2 2 0 0 2 2 2 2 NAD synthase ThiI PF02568.14 EPA05216.1 - 2.6e-06 27.1 0.0 0.00029 20.5 0.0 2.3 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 EPA05216.1 - 0.0001 21.2 0.0 0.0035 16.2 0.0 2.2 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.13 EPA05216.1 - 0.0057 16.2 0.0 0.38 10.2 0.0 2.2 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC Peptidase_C26 PF07722.13 EPA05216.1 - 0.018 14.8 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 Peptidase C26 ATP_bind_3 PF01171.20 EPA05216.1 - 0.11 12.2 0.1 0.24 11.1 0.0 1.5 2 0 0 2 2 2 0 PP-loop family CmcI PF04989.12 EPA05217.1 - 9.9e-85 283.4 0.3 1.2e-84 283.1 0.3 1.0 1 0 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_24 PF13578.6 EPA05217.1 - 4e-09 37.4 0.0 5.8e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA05217.1 - 0.018 14.9 0.1 0.025 14.3 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain Mur_ligase_C PF02875.21 EPA05217.1 - 0.018 15.3 0.0 0.038 14.2 0.0 1.5 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain TylF PF05711.11 EPA05217.1 - 0.025 13.9 0.1 0.044 13.1 0.1 1.5 1 1 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) DUF1269 PF06897.12 EPA05217.1 - 0.068 13.5 0.5 0.13 12.5 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) RST PF12174.8 EPA05217.1 - 0.11 12.4 3.5 0.21 11.6 1.2 2.4 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain Glycos_transf_2 PF00535.26 EPA05219.1 - 1.9e-26 92.9 0.0 3.1e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EPA05219.1 - 2.9e-19 69.9 0.0 4.3e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EPA05219.1 - 6.2e-07 29.5 0.0 9.8e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_4 PF13704.6 EPA05219.1 - 0.0038 17.7 0.0 0.0076 16.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EPA05219.1 - 0.061 12.8 0.0 0.12 11.8 0.0 1.4 1 1 0 1 1 1 0 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EPA05220.1 - 8e-24 84.3 0.1 1.1e-23 83.9 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EPA05220.1 - 8e-05 22.6 0.0 0.00011 22.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 PGM_PMM_II PF02879.16 EPA05220.1 - 0.013 16.2 0.1 0.04 14.5 0.1 1.9 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II TTRAP PF14203.6 EPA05220.1 - 0.016 15.2 0.0 0.47 10.5 0.0 2.9 3 0 0 3 3 3 0 Putative tranposon-transfer assisting protein CTP_transf_3 PF02348.19 EPA05220.1 - 0.02 14.8 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 Cytidylyltransferase Glyco_tranf_2_4 PF13704.6 EPA05220.1 - 0.12 12.9 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 TMEM100 PF16311.5 EPA05220.1 - 0.13 11.9 2.6 0.24 11.0 2.6 1.4 1 0 0 1 1 1 0 Transmembrane protein 100 DUF2207 PF09972.9 EPA05220.1 - 0.29 9.9 5.2 0.37 9.5 5.2 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Glycos_transf_1 PF00534.20 EPA05221.1 - 9.7e-27 93.6 0.0 1.6e-26 92.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EPA05221.1 - 4.2e-21 75.8 0.0 6e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EPA05221.1 - 1.3e-11 44.8 0.0 2.8e-10 40.5 0.0 2.2 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EPA05221.1 - 0.043 14.2 0.0 0.083 13.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 NUMOD4 PF07463.11 EPA05221.1 - 0.15 12.3 0.2 0.51 10.6 0.0 2.0 2 0 0 2 2 2 0 NUMOD4 motif Epimerase PF01370.21 EPA05222.1 - 6.8e-09 35.5 0.0 6.8e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EPA05222.1 - 8.1e-08 32.0 0.0 8.6e-08 31.9 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EPA05222.1 - 9.5e-05 21.9 0.0 9.5e-05 21.9 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 EPA05222.1 - 0.00015 21.0 0.0 0.00015 21.0 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EPA05222.1 - 0.00031 20.7 0.0 0.00035 20.5 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EPA05222.1 - 0.00039 20.0 0.0 0.00041 20.0 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 EPA05222.1 - 0.0018 17.5 0.0 0.0018 17.5 0.0 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EPA05222.1 - 0.0031 16.5 0.0 0.0031 16.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EPA05222.1 - 0.0074 15.5 0.0 0.0079 15.4 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein DapB_N PF01113.20 EPA05222.1 - 0.042 14.0 0.0 0.045 13.9 0.0 1.1 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Ldh_1_N PF00056.23 EPA05222.1 - 0.097 12.8 0.0 0.097 12.8 0.0 1.1 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 EPA05223.1 - 7.8e-35 120.8 0.0 2.4e-34 119.3 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EPA05223.1 - 2.4e-31 109.0 0.0 3.7e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EPA05223.1 - 1e-14 54.4 0.0 6.3e-14 51.8 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EPA05223.1 - 2.6e-09 36.5 0.0 3.4e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EPA05223.1 - 2.1e-07 30.3 0.0 2.8e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EPA05223.1 - 1.6e-05 24.2 0.0 6.9e-05 22.1 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein DMP12 PF16779.5 EPA05223.1 - 1.1 9.3 5.5 9.9 6.2 0.2 2.9 3 0 0 3 3 3 0 DNA-mimic protein PMT_2 PF13231.6 EPA05224.1 - 8.8e-09 35.8 13.2 8.8e-09 35.8 13.2 2.9 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Sec20 PF03908.13 EPA05224.1 - 2.1 8.3 4.1 20 5.2 1.9 2.8 2 0 0 2 2 2 0 Sec20 Methyltransf_14 PF08484.11 EPA05225.1 - 2.7e-65 219.1 0.0 4.7e-65 218.3 0.0 1.4 1 0 0 1 1 1 1 C-methyltransferase C-terminal domain Methyltransf_13 PF08421.11 EPA05225.1 - 2.9e-19 69.1 1.0 5.1e-19 68.3 1.0 1.4 1 0 0 1 1 1 1 Putative zinc binding domain Methyltransf_23 PF13489.6 EPA05225.1 - 4e-14 52.8 0.0 7.4e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA05225.1 - 1.1e-08 35.7 0.0 3.3e-08 34.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA05225.1 - 1.7e-08 34.4 0.1 3.7e-08 33.3 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA05225.1 - 4.8e-07 30.3 0.0 1.3e-06 28.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA05225.1 - 8.5e-05 23.2 0.0 0.00027 21.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MetW PF07021.12 EPA05225.1 - 0.066 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_21 PF05050.12 EPA05226.1 - 6.4e-17 62.1 1.8 2e-16 60.5 1.8 1.7 1 1 0 1 1 1 1 Methyltransferase FkbM domain V_cholerae_RfbT PF05575.11 EPA05226.1 - 3.7e-08 33.0 2.3 4.4e-08 32.7 2.3 1.2 1 0 0 1 1 1 1 Vibrio cholerae RfbT protein Met_10 PF02475.16 EPA05226.1 - 1.3e-06 28.3 0.1 2.5e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methylase_S PF01420.19 EPA05226.1 - 0.014 15.6 0.5 0.014 15.6 0.5 2.0 2 0 0 2 2 2 0 Type I restriction modification DNA specificity domain DUF5009 PF16401.5 EPA05226.1 - 0.15 11.5 0.1 0.21 11.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5009) SL4P PF17618.2 EPA05226.1 - 0.27 11.3 4.9 1.1 9.3 1.0 2.8 3 0 0 3 3 3 0 Uncharacterized Strongylid L4 protein Methyltransf_11 PF08241.12 EPA05228.1 - 1.1e-14 54.9 0.0 2.1e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA05228.1 - 1.3e-13 51.4 0.0 2.8e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA05228.1 - 1e-10 41.6 0.0 1.7e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EPA05228.1 - 3.5e-09 36.7 0.0 5.4e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA05228.1 - 4.2e-07 30.6 0.0 7.8e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EPA05228.1 - 0.0013 18.2 0.0 0.0026 17.2 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 EPA05228.1 - 0.0034 16.4 0.0 0.0053 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MetW PF07021.12 EPA05228.1 - 0.012 15.2 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Zn_ribbon_recom PF13408.6 EPA05228.1 - 0.057 13.9 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Glucokinase PF02685.16 EPA05228.1 - 0.22 10.5 0.0 0.35 9.8 0.0 1.2 1 0 0 1 1 1 0 Glucokinase NeuB PF03102.14 EPA05229.1 - 1.4e-81 273.5 0.0 1.7e-81 273.2 0.0 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.12 EPA05229.1 - 0.013 16.1 0.0 0.035 14.7 0.0 1.7 1 0 0 1 1 1 0 SAF domain COMM_domain PF07258.14 EPA05229.1 - 0.09 12.9 0.0 0.31 11.2 0.0 1.9 2 0 0 2 2 2 0 COMM domain RmlD_sub_bind PF04321.17 EPA05230.1 - 6.6e-21 74.7 0.0 7.7e-21 74.4 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EPA05230.1 - 2.2e-15 56.8 0.1 2.6e-15 56.6 0.1 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EPA05230.1 - 6.8e-09 35.3 2.5 1.7e-07 30.7 0.3 2.0 1 1 1 2 2 2 2 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EPA05230.1 - 2.2e-08 33.5 3.0 7.6e-08 31.7 3.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EPA05230.1 - 1.1e-07 31.5 1.1 1.1e-06 28.3 1.1 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EPA05230.1 - 7.6e-06 25.3 0.5 2.1e-05 23.9 0.1 1.7 1 1 0 2 2 2 1 Male sterility protein Semialdhyde_dh PF01118.24 EPA05230.1 - 0.0051 17.2 0.0 0.0057 17.1 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Phage_head_fibr PF11133.8 EPA05230.1 - 0.012 15.1 0.8 0.018 14.4 0.8 1.3 1 1 0 1 1 1 0 Head fiber protein DapB_N PF01113.20 EPA05230.1 - 0.064 13.4 0.1 0.099 12.8 0.1 1.6 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NTP_transferase PF00483.23 EPA05231.1 - 1.5e-54 185.2 0.0 1.9e-54 184.9 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EPA05231.1 - 1.6e-10 40.3 14.0 2.8e-06 26.8 0.8 3.3 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EPA05231.1 - 1.7e-10 41.5 0.0 2.3e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EPA05231.1 - 1.6e-05 24.5 8.6 0.00018 21.2 6.0 2.9 1 1 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase STN PF07660.14 EPA05231.1 - 0.098 12.5 0.1 0.26 11.1 0.0 1.8 2 0 0 2 2 2 0 Secretin and TonB N terminus short domain Fucokinase PF07959.12 EPA05231.1 - 0.17 10.8 3.7 0.38 9.6 3.7 1.6 1 1 0 1 1 1 0 L-fucokinase DegT_DnrJ_EryC1 PF01041.17 EPA05232.1 - 2.5e-71 240.9 0.0 3e-71 240.6 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Glyco_transf_4 PF13439.6 EPA05233.1 - 6.7e-06 26.2 0.2 3.2e-05 24.0 0.2 1.8 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EPA05233.1 - 0.0054 17.2 0.0 0.012 16.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Epimerase_2 PF02350.19 EPA05233.1 - 0.015 14.2 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase Glyco_trans_1_3 PF13528.6 EPA05233.1 - 0.098 11.9 0.0 0.19 11.0 0.0 1.4 1 1 0 1 1 1 0 Glycosyl transferase family 1 Methyltransf_23 PF13489.6 EPA05234.1 - 5.1e-17 62.2 0.0 6.8e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA05234.1 - 1.5e-11 44.8 0.0 2.4e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA05234.1 - 1e-10 42.2 0.0 2e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA05234.1 - 7e-09 36.3 0.0 1.4e-08 35.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA05234.1 - 1e-06 28.6 0.0 1.5e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 EPA05234.1 - 3.4e-05 23.5 0.0 4.7e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase TehB PF03848.14 EPA05234.1 - 0.00081 18.8 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB MetW PF07021.12 EPA05234.1 - 0.0042 16.7 0.0 0.022 14.4 0.0 1.9 1 1 1 2 2 2 1 Methionine biosynthesis protein MetW TPMT PF05724.11 EPA05234.1 - 0.079 12.6 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Formyl_trans_N PF00551.19 EPA05235.1 - 1.2e-09 38.2 0.0 1.4e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase KMP11 PF03037.16 EPA05236.1 - 0.05 14.4 4.3 0.17 12.7 4.3 1.9 1 1 0 1 1 1 0 Kinetoplastid membrane protein 11 NTP_transferase PF00483.23 EPA05237.1 - 5e-20 72.1 0.0 8.7e-20 71.3 0.0 1.4 1 1 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EPA05237.1 - 3.8e-09 37.1 0.0 6e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 EPA05237.1 - 0.033 13.9 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Hexapep PF00132.24 EPA05239.1 - 8.4e-08 31.6 14.4 0.00011 21.7 4.0 3.8 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EPA05239.1 - 8.1e-05 22.3 13.3 0.56 10.0 0.2 4.4 2 2 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase TylF PF05711.11 EPA05240.1 - 2.2e-23 82.9 0.0 3e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 EPA05240.1 - 3.2e-09 37.8 0.0 4.5e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Polysacc_synt_2 PF02719.15 EPA05241.1 - 1.6e-96 322.9 0.3 2e-96 322.6 0.3 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EPA05241.1 - 1.2e-29 103.4 0.1 1.1e-28 100.4 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EPA05241.1 - 5.4e-22 78.1 0.2 1.2e-20 73.7 0.1 2.1 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EPA05241.1 - 6.6e-21 75.0 0.0 7.5e-19 68.3 0.0 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EPA05241.1 - 6.5e-16 58.3 0.0 7.7e-14 51.5 0.0 2.5 1 1 1 2 2 2 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EPA05241.1 - 2.7e-11 43.7 0.0 4.8e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EPA05241.1 - 5.2e-11 42.2 2.4 9e-08 31.6 2.2 3.0 1 1 1 2 2 2 2 Male sterility protein NmrA PF05368.13 EPA05241.1 - 1.7e-07 31.1 0.1 2.7e-07 30.4 0.1 1.5 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EPA05241.1 - 1.8e-07 30.8 0.0 3.3e-07 29.9 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EPA05241.1 - 2.3e-05 24.4 0.0 4e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EPA05241.1 - 0.0048 17.0 0.3 0.025 14.6 0.0 2.3 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EPA05241.1 - 0.013 16.0 0.0 0.063 13.9 0.0 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 EPA05241.1 - 0.045 14.2 0.0 0.63 10.5 0.0 2.5 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EPA05241.1 - 0.13 12.3 0.0 0.33 10.9 0.0 1.8 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF2526 PF10735.9 EPA05242.1 - 0.072 13.3 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2526) RmlD_sub_bind PF04321.17 EPA05243.1 - 1.9e-10 40.4 0.0 2.2e-10 40.1 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EPA05244.1 - 9e-74 248.8 0.0 1.1e-73 248.6 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EPA05244.1 - 2e-55 187.9 0.0 2.5e-55 187.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EPA05244.1 - 1.1e-20 73.8 0.1 1.4e-20 73.4 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EPA05244.1 - 5e-14 52.1 0.0 3.8e-13 49.2 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EPA05244.1 - 6.3e-14 51.7 0.0 7.5e-14 51.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EPA05244.1 - 2e-11 43.6 0.7 3.5e-10 39.5 0.7 2.4 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EPA05245.1 - 1.9e-39 136.0 0.0 3e-39 135.3 0.0 1.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EPA05245.1 - 1.3e-35 123.0 0.0 1.5e-35 122.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EPA05245.1 - 1.3e-08 34.3 0.0 1.7e-08 33.9 0.0 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EPA05245.1 - 0.0021 17.2 0.0 0.014 14.5 0.0 2.1 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EPA05245.1 - 0.0033 16.6 0.0 0.0048 16.1 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein FdtA PF05523.11 EPA05246.1 - 1.3e-22 80.0 0.4 1.5e-22 79.7 0.4 1.0 1 0 0 1 1 1 1 WxcM-like, C-terminal Cupin_2 PF07883.11 EPA05246.1 - 3.3e-05 23.5 0.1 0.0003 20.4 0.1 2.1 1 1 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EPA05246.1 - 0.00062 19.4 0.0 0.00073 19.2 0.0 1.2 1 0 0 1 1 1 1 Cupin ARD PF03079.14 EPA05246.1 - 0.067 13.4 0.1 0.087 13.0 0.1 1.3 1 1 0 1 1 1 0 ARD/ARD' family dTDP_sugar_isom PF00908.17 EPA05247.1 - 6.2e-63 211.5 0.0 6.9e-63 211.3 0.0 1.0 1 0 0 1 1 1 1 dTDP-4-dehydrorhamnose 3,5-epimerase FdtA PF05523.11 EPA05247.1 - 0.0026 17.5 0.0 0.0041 16.9 0.0 1.3 1 0 0 1 1 1 1 WxcM-like, C-terminal Strep_pep PF14404.6 EPA05248.1 - 0.082 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Streptomyces species DUF3473 PF11959.8 EPA05249.1 - 2.9e-33 114.6 0.1 5.2e-33 113.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3473) Polysacc_deac_1 PF01522.21 EPA05249.1 - 5.3e-22 78.0 0.0 8.4e-22 77.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EPA05249.1 - 9.7e-06 25.4 0.0 2.2e-05 24.2 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Glyoxalase_4 PF13669.6 EPA05250.1 - 1.3e-15 57.6 0.0 1.7e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 EPA05250.1 - 0.007 16.6 0.0 0.01 16.0 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PTE PF02126.18 EPA05250.1 - 0.039 13.4 0.0 0.041 13.3 0.0 1.1 1 0 0 1 1 1 0 Phosphotriesterase family CbiX PF01903.17 EPA05250.1 - 0.14 12.5 0.0 0.58 10.5 0.0 1.9 1 1 1 2 2 2 0 CbiX Glyoxalase_3 PF13468.6 EPA05250.1 - 0.18 11.9 0.0 0.4 10.8 0.0 1.5 2 0 0 2 2 2 0 Glyoxalase-like domain ACPS PF01648.20 EPA05251.1 - 5.8e-14 52.2 0.5 6.7e-14 52.0 0.5 1.1 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily DUF5001 PF16392.5 EPA05251.1 - 0.017 15.0 4.0 0.086 12.7 0.6 2.1 1 1 1 2 2 2 0 Ig-like domain Ta0938 PF11494.8 EPA05251.1 - 0.064 13.5 1.7 0.33 11.2 0.0 2.0 1 1 0 2 2 2 0 Ta0938 Glyphos_transf PF04464.14 EPA05252.1 - 0.00017 20.7 1.8 0.0015 17.6 1.8 2.1 1 1 0 1 1 1 1 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase Epimerase_2 PF02350.19 EPA05252.1 - 0.0002 20.4 0.1 0.00043 19.2 0.1 1.6 2 0 0 2 2 2 1 UDP-N-acetylglucosamine 2-epimerase Glycos_transf_1 PF00534.20 EPA05253.1 - 1.5e-19 70.2 0.0 2e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EPA05253.1 - 3.8e-19 69.5 0.0 4.7e-19 69.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EPA05253.1 - 1.6e-09 38.0 0.0 2.2e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 RTT107_BRCT_6 PF16771.5 EPA05254.1 - 0.019 15.1 0.2 0.028 14.6 0.2 1.2 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain Guanylate_cyc PF00211.20 EPA05255.1 - 1.6e-16 60.5 0.1 2.1e-16 60.1 0.1 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Aldo_ket_red PF00248.21 EPA05256.1 - 5e-25 88.3 0.2 1.5e-19 70.3 0.2 2.5 1 1 1 2 2 2 2 Aldo/keto reductase family Arc_PepC PF06819.11 EPA05256.1 - 0.054 13.6 0.8 0.12 12.5 0.1 1.9 2 0 0 2 2 2 0 Archaeal Peptidase A24 C-terminal Domain DUF321 PF03778.13 EPA05256.1 - 0.29 10.8 3.2 0.22 11.2 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF321) RNA_pol_Rpb6 PF01192.22 EPA05258.1 - 2.1e-11 43.5 0.4 4.4e-11 42.5 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb6 Med9 PF07544.13 EPA05258.1 - 0.011 15.8 0.7 0.024 14.7 0.7 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF5344 PF17279.2 EPA05258.1 - 0.013 16.0 1.0 0.023 15.2 1.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5344) Unstab_antitox PF09720.10 EPA05258.1 - 0.37 10.9 4.6 0.23 11.5 1.1 2.5 3 0 0 3 3 3 0 Putative addiction module component DS PF01916.17 EPA05259.1 - 1.1e-77 261.2 0.1 1.4e-77 260.9 0.1 1.1 1 0 0 1 1 1 1 Deoxyhypusine synthase Asn_synthase PF00733.21 EPA05260.1 - 4.3e-37 128.6 0.0 5.5e-21 75.6 0.0 2.0 1 1 0 2 2 2 2 Asparagine synthase NAD_synthase PF02540.17 EPA05260.1 - 1.4e-05 24.4 0.1 2.7e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 NAD synthase QueC PF06508.13 EPA05260.1 - 6.3e-05 22.6 1.5 0.00015 21.3 0.1 2.4 2 1 0 2 2 2 1 Queuosine biosynthesis protein QueC ATP_bind_3 PF01171.20 EPA05260.1 - 0.00014 21.6 0.0 0.00031 20.5 0.0 1.6 1 0 0 1 1 1 1 PP-loop family ThiI PF02568.14 EPA05260.1 - 0.0013 18.3 0.0 0.0027 17.3 0.0 1.5 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 EPA05260.1 - 0.0038 16.1 0.0 0.012 14.5 0.0 1.8 2 1 0 2 2 2 1 tRNA methyl transferase DZR PF12773.7 EPA05260.1 - 0.19 11.8 2.4 0.73 9.9 0.6 2.3 2 0 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 EPA05260.1 - 1.3 8.5 3.6 0.48 9.9 0.4 1.9 2 0 0 2 2 2 0 zinc-ribbon domain RecR PF02132.15 EPA05260.1 - 1.4 8.5 7.3 0.14 11.8 1.6 2.3 2 0 0 2 2 2 0 RecR protein zinc_ribbon_2 PF13240.6 EPA05260.1 - 2.1 8.1 5.3 88 3.0 6.1 2.6 1 1 1 2 2 2 0 zinc-ribbon domain Auto_anti-p27 PF06677.12 EPA05260.1 - 2.2 8.5 5.4 7 6.9 0.1 2.6 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Alba PF01918.21 EPA05262.1 - 2e-09 37.1 0.4 2.9e-09 36.6 0.4 1.3 1 0 0 1 1 1 1 Alba Ribosomal_L2 PF00181.23 EPA05262.1 - 0.048 13.6 0.1 0.13 12.2 0.1 1.7 2 0 0 2 2 2 0 Ribosomal Proteins L2, RNA binding domain Cyclophil_like PF04126.13 EPA05265.1 - 4.7e-09 36.1 0.0 6.7e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin-like Cyclophil_like2 PF18050.1 EPA05265.1 - 4.6e-08 33.0 0.0 7.5e-08 32.3 0.0 1.3 1 1 0 1 1 1 1 Cyclophilin-like family DUF3830 PF12903.7 EPA05265.1 - 0.012 15.3 0.0 0.038 13.7 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3830) Ribosomal_S25 PF03297.15 EPA05268.1 - 3.4e-10 40.0 4.7 4.4e-10 39.7 4.7 1.1 1 0 0 1 1 1 1 S25 ribosomal protein DDRGK PF09756.9 EPA05268.1 - 0.0086 15.7 2.8 0.024 14.2 2.8 1.6 1 1 0 1 1 1 1 DDRGK domain DUF977 PF06163.11 EPA05268.1 - 0.0098 15.8 0.1 0.012 15.5 0.1 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF977) TrmB PF01978.19 EPA05268.1 - 0.024 14.5 0.1 0.031 14.1 0.1 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 EPA05268.1 - 0.045 13.3 0.0 0.061 12.9 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 EPA05268.1 - 0.06 13.2 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 MarR family UbiA PF01040.18 EPA05269.1 - 7.8e-26 90.9 13.4 7.8e-26 90.9 13.4 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family T4SS_CagC PF16943.5 EPA05269.1 - 0.038 14.1 1.5 0.15 12.3 0.2 2.4 2 1 0 2 2 2 0 Cag pathogenicity island, type IV secretory system Tom6 PF17112.5 EPA05269.1 - 0.35 10.4 3.8 0.41 10.2 0.3 2.8 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom6, fungal DUF3488 PF11992.8 EPA05269.1 - 2.1 7.3 9.6 0.035 13.0 2.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3488) Big_1 PF02369.16 EPA05270.1 - 1.7e-05 24.7 3.3 1.7e-05 24.7 3.3 3.7 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 1) Invasin_D3 PF09134.10 EPA05270.1 - 0.00027 21.2 21.2 0.01 16.2 1.5 5.7 5 0 0 5 5 5 2 Invasin, domain 3 CarboxypepD_reg PF13620.6 EPA05270.1 - 0.0094 16.2 2.7 0.019 15.3 0.4 2.7 4 0 0 4 4 4 1 Carboxypeptidase regulatory-like domain Rhabdo_glycop PF00974.18 EPA05270.1 - 0.02 13.4 0.0 0.03 12.8 0.0 1.2 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein Big_3 PF07523.12 EPA05270.1 - 0.084 13.2 1.9 0.18 12.2 0.2 2.5 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) Spore_YhaL PF14147.6 EPA05270.1 - 0.21 11.3 0.6 0.52 10.1 0.6 1.7 1 0 0 1 1 1 0 Sporulation protein YhaL NPCBM_assoc PF10633.9 EPA05272.1 - 0.0021 18.3 0.6 0.03 14.6 0.8 2.4 2 0 0 2 2 2 1 NPCBM-associated, NEW3 domain of alpha-galactosidase YHS PF04945.13 EPA05273.1 - 1.6e-11 44.1 0.1 2e-11 43.8 0.1 1.1 1 0 0 1 1 1 1 YHS domain ATPase-cat_bd PF12156.8 EPA05273.1 - 5.5e-05 23.8 0.5 6.9e-05 23.5 0.5 1.1 1 0 0 1 1 1 1 Putative metal-binding domain of cation transport ATPase Ta0938 PF11494.8 EPA05273.1 - 0.00069 19.9 0.2 0.00069 19.9 0.2 1.1 1 0 0 1 1 1 1 Ta0938 Arc_trans_TRASH PF08394.10 EPA05273.1 - 0.0056 17.0 1.1 0.0076 16.6 1.1 1.2 1 0 0 1 1 1 1 Archaeal TRASH domain Prok-JAB PF14464.6 EPA05274.1 - 1.4e-10 41.0 0.0 1.6e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain HTH_3 PF01381.22 EPA05275.1 - 7.3e-05 22.7 0.0 0.00017 21.5 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix HTH_23 PF13384.6 EPA05275.1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain HTH_11 PF08279.12 EPA05275.1 - 0.081 12.9 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 HTH domain YdaS_antitoxin PF15943.5 EPA05275.1 - 0.17 11.8 0.0 0.57 10.1 0.0 2.0 1 1 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Rpr2 PF04032.16 EPA05275.1 - 0.17 12.2 0.9 0.34 11.2 0.9 1.9 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Pilin_N PF07790.11 EPA05276.1 - 0.01 16.7 3.2 0.01 16.7 3.2 1.9 2 1 0 2 2 2 0 Archaeal Type IV pilin, N-terminal CbiD PF01888.17 EPA05278.1 - 4.8e-78 261.9 0.8 5.4e-78 261.8 0.8 1.0 1 0 0 1 1 1 1 CbiD DUF3042 PF11240.8 EPA05278.1 - 0.031 14.3 0.2 0.1 12.6 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) LapA_dom PF06305.11 EPA05279.1 - 0.0079 16.0 0.0 0.021 14.7 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain adh_short_C2 PF13561.6 EPA05280.1 - 7.3e-55 186.1 0.0 9.2e-55 185.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EPA05280.1 - 7.2e-52 175.7 0.1 9.1e-52 175.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EPA05280.1 - 5.7e-10 39.4 0.0 3e-09 37.0 0.0 1.9 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EPA05280.1 - 6.7e-08 32.3 0.0 2e-07 30.8 0.0 1.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family P3A PF08727.11 EPA05280.1 - 0.051 13.0 0.3 0.15 11.4 0.3 1.8 1 0 0 1 1 1 0 Poliovirus 3A protein like THF_DHG_CYH_C PF02882.19 EPA05280.1 - 0.058 12.7 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF840 PF05801.11 EPA05280.1 - 0.3 11.2 2.8 0.36 10.9 1.1 1.9 2 0 0 2 2 2 0 Lagovirus protein of unknown function (DUF840) Epimerase PF01370.21 EPA05281.1 - 1.4e-11 44.4 0.0 1e-10 41.5 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EPA05281.1 - 4.5e-10 39.7 0.0 6.5e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EPA05281.1 - 1.6e-07 31.1 1.4 5.3e-07 29.4 1.4 1.7 1 1 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 EPA05281.1 - 2e-07 30.3 0.2 0.00014 20.9 0.3 2.3 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EPA05281.1 - 2.1e-05 23.8 0.4 0.22 10.7 0.0 2.8 2 1 1 3 3 3 2 Male sterility protein RmlD_sub_bind PF04321.17 EPA05281.1 - 0.00032 19.9 0.0 0.017 14.3 0.0 2.2 2 1 0 2 2 2 1 RmlD substrate binding domain AP_endonuc_2 PF01261.24 EPA05281.1 - 0.035 13.5 0.0 0.055 12.9 0.0 1.2 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Polysacc_synt_2 PF02719.15 EPA05281.1 - 0.041 13.0 0.2 0.62 9.1 0.2 2.2 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EPA05281.1 - 0.5 10.4 2.4 0.57 10.2 0.2 2.2 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase S-AdoMet_synt_C PF02773.16 EPA05282.1 - 6.4e-70 233.5 0.1 7.8e-69 230.0 0.0 2.0 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EPA05282.1 - 4.7e-34 117.2 0.4 8.3e-34 116.4 0.4 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain adh_short_C2 PF13561.6 EPA05283.1 - 8.5e-54 182.6 0.1 1e-52 179.1 0.1 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EPA05283.1 - 1.9e-44 151.5 3.6 8.3e-40 136.3 0.3 2.1 1 1 1 2 2 2 2 short chain dehydrogenase Epimerase PF01370.21 EPA05283.1 - 0.00034 20.2 0.3 0.0013 18.2 0.3 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EPA05283.1 - 0.0084 16.0 0.0 0.016 15.1 0.0 1.4 1 1 1 2 2 2 1 KR domain RmlD_sub_bind PF04321.17 EPA05283.1 - 0.021 13.9 0.0 0.03 13.4 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain NAD_binding_3 PF03447.16 EPA05283.1 - 0.13 12.9 0.4 0.49 11.1 0.0 2.1 2 1 1 3 3 3 0 Homoserine dehydrogenase, NAD binding domain Glycos_transf_2 PF00535.26 EPA05284.1 - 2.6e-19 69.6 0.4 4e-19 69.1 0.4 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EPA05284.1 - 4.2e-06 26.8 0.0 5.3e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EPA05284.1 - 4.7e-05 23.0 0.4 4.7e-05 23.0 0.4 1.8 2 1 0 2 2 2 1 Glycosyltransferase like family 2 PRD PF00874.20 EPA05285.1 - 0.1 12.9 2.2 1.8 8.9 0.2 2.1 1 1 1 2 2 2 0 PRD domain Epimerase PF01370.21 EPA05286.1 - 3.7e-11 43.0 0.0 4.8e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EPA05286.1 - 6.5e-10 38.5 0.0 9.7e-10 37.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EPA05286.1 - 4.7e-07 29.2 0.1 0.00091 18.4 0.0 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EPA05286.1 - 0.00013 21.2 0.0 0.00071 18.8 0.0 1.9 1 1 1 2 2 2 1 Male sterility protein Pyr_redox PF00070.27 EPA05286.1 - 0.031 14.9 0.0 0.085 13.4 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Semialdhyde_dh PF01118.24 EPA05286.1 - 0.04 14.4 0.0 0.099 13.1 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EPA05286.1 - 0.058 12.6 0.0 0.13 11.5 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EPA05286.1 - 0.097 11.9 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 EPA05286.1 - 0.12 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EPA05286.1 - 0.13 12.5 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain SIS_2 PF13580.6 EPA05287.1 - 6.3e-28 97.5 0.3 9.1e-28 97.0 0.3 1.2 1 0 0 1 1 1 1 SIS domain SIS PF01380.22 EPA05287.1 - 8e-06 25.7 0.5 0.00033 20.5 0.0 2.5 1 1 0 2 2 2 1 SIS domain Vps54_N PF10475.9 EPA05287.1 - 0.032 13.5 0.5 0.056 12.7 0.5 1.4 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex Tex_YqgF PF16921.5 EPA05287.1 - 0.074 13.5 0.4 0.45 11.0 0.2 2.1 2 0 0 2 2 2 0 Tex protein YqgF-like domain Epimerase PF01370.21 EPA05288.1 - 0.00093 18.7 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EPA05288.1 - 0.11 11.9 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Hydrolase_3 PF08282.12 EPA05290.1 - 1.9e-12 47.5 0.0 2.2e-12 47.2 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EPA05290.1 - 0.0019 18.5 0.0 0.0025 18.1 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EPA05290.1 - 0.0097 16.0 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Gamma-thionin PF00304.20 EPA05290.1 - 0.046 14.0 4.0 0.89 9.9 0.6 2.1 2 0 0 2 2 2 0 Gamma-thionin family Toxin_3 PF00537.18 EPA05290.1 - 0.12 12.6 5.7 2 8.7 0.8 2.2 2 0 0 2 2 2 0 Scorpion toxin-like domain TrmB PF01978.19 EPA05291.1 - 4.3e-21 74.6 0.0 1.4e-20 72.9 0.0 1.9 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 EPA05291.1 - 1e-07 31.4 0.0 1.3e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB HTH_IclR PF09339.10 EPA05291.1 - 3.8e-05 23.4 0.0 0.0002 21.1 0.0 2.1 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR PF01047.22 EPA05291.1 - 0.0012 18.7 0.0 0.0042 17.0 0.0 1.9 1 1 1 2 2 2 1 MarR family HTH_24 PF13412.6 EPA05291.1 - 0.0063 16.0 0.0 0.016 14.7 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Penicillinase_R PF03965.16 EPA05291.1 - 0.0067 16.8 0.1 0.042 14.2 0.0 2.1 2 0 0 2 2 2 1 Penicillinase repressor HTH_27 PF13463.6 EPA05291.1 - 0.0082 16.6 0.0 0.022 15.2 0.0 1.7 1 0 0 1 1 1 1 Winged helix DNA-binding domain Rrf2 PF02082.20 EPA05291.1 - 0.056 13.8 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 Transcriptional regulator PLDc_2 PF13091.6 EPA05291.1 - 0.089 12.7 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 PLD-like domain PadR PF03551.14 EPA05291.1 - 0.13 12.3 0.0 0.31 11.0 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family MarR_2 PF12802.7 EPA05291.1 - 0.17 11.8 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 MarR family DUF1494 PF07379.11 EPA05292.1 - 0.11 12.4 1.7 4.6 7.0 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1494) AP_endonuc_2 PF01261.24 EPA05293.1 - 2.4e-15 56.6 0.0 3.2e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF1463 PF07316.11 EPA05293.1 - 0.019 14.8 0.5 0.033 14.0 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1463) TSC22 PF01166.18 EPA05293.1 - 0.073 13.4 0.0 0.28 11.5 0.0 2.0 1 0 0 1 1 1 0 TSC-22/dip/bun family HAD_2 PF13419.6 EPA05294.1 - 2.4e-11 44.0 4.9 1.9e-09 37.9 4.9 2.1 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EPA05294.1 - 6.7e-11 42.1 0.0 9.9e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like PNK3P PF08645.11 EPA05294.1 - 1.2e-10 41.3 1.0 1.5e-10 41.0 1.0 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase HAD PF12710.7 EPA05294.1 - 2.2e-05 24.9 0.0 2.7e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EPA05294.1 - 0.00016 22.0 0.0 0.00026 21.4 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 EPA05294.1 - 0.00064 19.4 0.2 0.00095 18.8 0.2 1.2 1 0 0 1 1 1 1 HAD superfamily, subfamily IIIB (Acid phosphatase) HAD_SAK_2 PF18143.1 EPA05294.1 - 0.0097 16.2 0.1 0.0099 16.2 0.1 1.3 1 1 0 1 1 1 1 HAD domain in Swiss Army Knife RNA repair proteins Hydrolase_6 PF13344.6 EPA05294.1 - 0.012 15.8 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase AP_endonuc_2 PF01261.24 EPA05295.1 - 8.8e-10 38.4 0.0 1.3e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF692 PF05114.13 EPA05295.1 - 0.011 15.0 0.2 0.015 14.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF692) Epimerase PF01370.21 EPA05296.1 - 2.5e-23 82.8 0.0 2.9e-23 82.6 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EPA05296.1 - 9.6e-22 77.8 0.0 1.1e-21 77.6 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EPA05296.1 - 2.1e-15 56.6 0.0 2.5e-15 56.4 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EPA05296.1 - 9.1e-14 51.1 0.0 1.1e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EPA05296.1 - 2.5e-13 49.8 0.0 2.2e-12 46.7 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EPA05296.1 - 1.9e-05 23.9 0.5 0.0048 16.1 0.5 2.8 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EPA05296.1 - 0.00046 20.1 0.0 0.00051 20.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EPA05296.1 - 0.00047 19.7 0.0 0.0007 19.1 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 EPA05296.1 - 0.0005 19.7 0.0 0.00067 19.3 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family TrkA_N PF02254.18 EPA05296.1 - 0.0019 18.5 0.0 0.0026 18.0 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 EPA05296.1 - 0.0024 18.1 0.0 0.0039 17.5 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 EPA05296.1 - 0.051 13.5 0.1 0.079 12.9 0.1 1.4 1 1 0 1 1 1 0 KR domain Pyr_redox PF00070.27 EPA05296.1 - 0.11 13.1 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EPA05296.1 - 0.18 11.0 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Polysacc_synt_C PF14667.6 EPA05298.1 - 7.2e-07 29.4 1.5 7.2e-07 29.4 1.5 4.4 3 2 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Polysacc_synt_3 PF13440.6 EPA05298.1 - 0.00072 18.9 25.2 0.017 14.4 3.0 3.2 1 1 0 3 3 3 3 Polysaccharide biosynthesis protein DUF4538 PF15061.6 EPA05298.1 - 0.28 11.0 1.7 1.1 9.0 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) Polysacc_synt PF01943.17 EPA05298.1 - 1.9 7.8 40.5 0.12 11.7 24.9 3.5 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein adh_short_C2 PF13561.6 EPA05299.1 - 7.7e-33 114.0 0.0 1e-32 113.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EPA05299.1 - 6.4e-16 58.4 0.0 8.8e-15 54.7 0.0 2.1 1 1 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 EPA05299.1 - 4.2e-07 29.4 0.0 6.5e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EPA05299.1 - 1.5e-06 27.8 0.0 4.7e-06 26.2 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF3473 PF11959.8 EPA05300.1 - 4.5e-29 101.1 0.0 8.4e-29 100.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3473) Polysacc_deac_1 PF01522.21 EPA05300.1 - 2.1e-14 53.5 0.0 3.7e-13 49.5 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide deacetylase DUF2334 PF10096.9 EPA05300.1 - 0.052 13.2 0.1 0.11 12.2 0.1 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) Asn_synthase PF00733.21 EPA05301.1 - 4.2e-26 92.5 0.0 5.5e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase GFO_IDH_MocA PF01408.22 EPA05302.1 - 9e-21 74.9 0.0 1.3e-20 74.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Rad60-SLD PF11976.8 EPA05302.1 - 0.18 11.7 0.8 1.1 9.1 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like NeuB PF03102.14 EPA05303.1 - 4.1e-51 173.8 0.0 4.9e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.12 EPA05303.1 - 0.069 13.8 0.0 0.16 12.6 0.0 1.7 2 0 0 2 2 2 0 SAF domain CTP_transf_3 PF02348.19 EPA05304.1 - 1.5e-10 41.4 0.0 1.6e-10 41.3 0.0 1.0 1 0 0 1 1 1 1 Cytidylyltransferase NeuB PF03102.14 EPA05305.1 - 1e-67 228.1 0.1 1.2e-67 227.9 0.1 1.0 1 0 0 1 1 1 1 NeuB family Fe_dep_repress PF01325.19 EPA05306.1 - 1.6e-11 44.2 0.1 2.3e-11 43.7 0.1 1.2 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain MarR PF01047.22 EPA05306.1 - 0.0054 16.6 0.0 0.0066 16.3 0.0 1.1 1 0 0 1 1 1 1 MarR family NLPC_P60 PF00877.19 EPA05306.1 - 0.025 14.6 0.0 0.028 14.5 0.0 1.1 1 0 0 1 1 1 0 NlpC/P60 family HTH_37 PF13744.6 EPA05306.1 - 0.031 14.2 0.0 0.038 14.0 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_27 PF13463.6 EPA05306.1 - 0.047 14.2 0.0 0.063 13.8 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain MarR_2 PF12802.7 EPA05306.1 - 0.051 13.5 0.0 0.063 13.2 0.0 1.2 1 0 0 1 1 1 0 MarR family Radical_SAM PF04055.21 EPA05307.1 - 6.8e-15 55.8 0.0 1.3e-13 51.7 0.0 2.3 2 0 0 2 2 2 1 Radical SAM superfamily B12-binding PF02310.19 EPA05307.1 - 1.6e-14 54.0 0.0 3.2e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 B12 binding domain Plasmo_rep PF12135.8 EPA05307.1 - 0.55 9.8 3.7 1.8 8.1 1.5 3.0 4 0 0 4 4 4 0 Plasmodium repeat family Glycos_transf_2 PF00535.26 EPA05308.1 - 9.5e-23 80.8 0.0 1.4e-22 80.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EPA05308.1 - 3.9e-16 59.6 0.0 6.8e-16 58.8 0.0 1.2 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EPA05308.1 - 0.00036 20.1 1.4 0.0016 17.9 0.1 2.2 3 0 0 3 3 3 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EPA05308.1 - 0.022 14.2 0.0 0.041 13.4 0.0 1.4 1 1 0 1 1 1 0 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 EPA05308.1 - 0.053 14.0 0.1 0.36 11.4 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 2 zf-TRM13_CCCH PF11722.8 EPA05308.1 - 0.091 12.5 1.8 0.12 12.1 0.2 2.1 2 0 0 2 2 2 0 CCCH zinc finger in TRM13 protein Phage_endo_I PF05367.11 EPA05309.1 - 0.0011 18.6 0.4 0.0013 18.4 0.4 1.1 1 0 0 1 1 1 1 Phage endonuclease I Helicase_IV_N PF12462.8 EPA05309.1 - 0.028 14.4 0.0 0.031 14.2 0.0 1.0 1 0 0 1 1 1 0 DNA helicase IV / RNA helicase N terminal Glycos_transf_1 PF00534.20 EPA05310.1 - 2.4e-34 118.3 1.1 5e-34 117.3 1.1 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EPA05310.1 - 2.3e-25 89.6 0.0 4.3e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EPA05310.1 - 3.1e-05 24.0 0.0 7.7e-05 22.8 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EPA05310.1 - 0.0065 16.8 0.0 0.022 15.2 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferases group 1 TylF PF05711.11 EPA05311.1 - 1.2e-23 83.7 0.3 1.4e-23 83.5 0.3 1.0 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 EPA05311.1 - 6e-13 49.7 0.0 8.1e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 EPA05311.1 - 0.0003 20.6 0.0 0.0023 17.6 0.0 2.1 3 0 0 3 3 3 1 Cephalosporin hydroxylase Methyltransf_3 PF01596.17 EPA05311.1 - 0.061 12.5 0.7 0.54 9.4 0.6 2.0 2 0 0 2 2 2 0 O-methyltransferase Epimerase_2 PF02350.19 EPA05312.1 - 4.3e-07 29.1 0.1 8.4e-07 28.2 0.1 1.5 1 1 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase Glyphos_transf PF04464.14 EPA05312.1 - 1.7e-05 24.0 1.8 0.00017 20.7 1.7 2.2 1 1 0 1 1 1 1 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase tRNA_NucTransf2 PF09249.11 EPA05312.1 - 0.018 15.3 0.0 0.055 13.7 0.0 1.8 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain ChiW_Ig_like PF18683.1 EPA05312.1 - 0.034 14.4 0.0 0.075 13.3 0.0 1.5 1 0 0 1 1 1 0 Chitinase W immunoglobulin-like domain Capsule_synth PF05159.14 EPA05312.1 - 0.075 12.5 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 Capsule polysaccharide biosynthesis protein Radical_SAM PF04055.21 EPA05313.1 - 3.3e-15 56.9 0.2 3.3e-15 56.9 0.2 2.5 3 0 0 3 3 3 1 Radical SAM superfamily Fer4_12 PF13353.6 EPA05313.1 - 1.1e-06 29.0 0.0 3.2e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EPA05313.1 - 1.7e-06 28.1 0.0 1.7e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain Methyltransf_21 PF05050.12 EPA05314.1 - 1.1e-11 45.1 0.3 1.9e-11 44.3 0.3 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain Met_10 PF02475.16 EPA05314.1 - 6.7e-06 26.0 0.0 1.1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein PCMT PF01135.19 EPA05314.1 - 0.00023 21.0 0.0 0.00029 20.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 EPA05314.1 - 0.011 15.2 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EPA05314.1 - 0.064 13.1 0.2 0.091 12.6 0.2 1.3 1 0 0 1 1 1 0 Methyltransferase domain GMP_synt_C PF00958.22 EPA05315.1 - 2.3e-35 120.5 0.1 5.1e-35 119.4 0.1 1.6 1 0 0 1 1 1 1 GMP synthase C terminal domain NAD_synthase PF02540.17 EPA05315.1 - 0.00039 19.6 0.0 0.00078 18.6 0.0 1.4 1 0 0 1 1 1 1 NAD synthase SPASM PF13186.6 EPA05316.1 - 1.1e-13 51.4 4.7 3.8e-13 49.8 3.9 2.4 2 0 0 2 2 2 1 Iron-sulfur cluster-binding domain Radical_SAM PF04055.21 EPA05316.1 - 1.2e-07 32.3 0.0 2.1e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Methyltransf_23 PF13489.6 EPA05317.1 - 8.7e-19 68.0 0.0 1.3e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA05317.1 - 4.2e-10 39.6 0.0 7.7e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA05317.1 - 6.9e-10 39.6 0.0 1.5e-09 38.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA05317.1 - 7e-09 36.2 0.0 1.4e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EPA05317.1 - 8.7e-08 32.0 0.2 1.5e-07 31.2 0.2 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_25 PF13649.6 EPA05317.1 - 3.6e-07 30.8 0.0 1e-06 29.4 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 EPA05317.1 - 7.3e-05 21.8 0.1 0.00011 21.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) DREV PF05219.12 EPA05317.1 - 0.0029 16.8 0.1 0.0048 16.0 0.1 1.3 1 0 0 1 1 1 1 DREV methyltransferase Sep15_SelM PF08806.11 EPA05317.1 - 0.0086 16.2 0.3 0.02 15.0 0.3 1.6 1 0 0 1 1 1 1 Sep15/SelM redox domain Methyltransf_32 PF13679.6 EPA05317.1 - 0.023 14.7 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain WBP-1 PF11669.8 EPA05318.1 - 0.014 16.0 0.1 0.025 15.2 0.1 1.5 1 0 0 1 1 1 0 WW domain-binding protein 1 Fig1 PF12351.8 EPA05318.1 - 0.041 13.8 2.0 0.055 13.4 2.0 1.2 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 DUF3810 PF12725.7 EPA05318.1 - 0.31 10.4 1.9 0.37 10.1 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Glyco_trans_1_4 PF13692.6 EPA05319.1 - 1.3e-12 48.3 0.0 2.5e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 EPA05319.1 - 0.00029 20.4 0.1 0.0012 18.4 0.0 2.1 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EPA05319.1 - 0.0017 18.7 0.0 0.014 15.8 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EPA05319.1 - 0.031 14.3 0.0 0.054 13.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 DUF3654 PF12376.8 EPA05319.1 - 0.032 14.4 0.3 0.093 12.9 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3654) Hydrolase_6 PF13344.6 EPA05321.1 - 0.0034 17.5 0.2 0.0095 16.0 0.2 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EPA05321.1 - 0.034 14.4 0.3 1.4 9.1 0.2 2.0 1 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase GHMP_kinases_N PF00288.26 EPA05322.1 - 8.5e-12 45.1 0.4 1.6e-11 44.2 0.4 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EPA05322.1 - 1.7e-05 25.1 1.7 1.8e-05 25.0 0.0 1.8 2 0 0 2 2 2 1 GHMP kinases C terminal UDPG_MGDP_dh_N PF03721.14 EPA05323.1 - 2.6e-40 138.0 0.3 5.4e-40 137.0 0.3 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 EPA05323.1 - 2.9e-21 75.5 0.0 5.4e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 EPA05323.1 - 3.3e-21 75.7 0.0 1.3e-20 73.8 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_Gly3P_dh_N PF01210.23 EPA05323.1 - 1.1e-06 28.7 0.1 0.00051 20.0 0.0 2.5 2 0 0 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 EPA05323.1 - 6.1e-06 25.7 2.2 0.029 13.7 0.0 3.3 2 2 1 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EPA05323.1 - 0.00014 21.8 0.0 0.00027 20.9 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EPA05323.1 - 0.0025 18.3 0.5 4.1 8.0 0.0 2.9 2 1 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent ThiF PF00899.21 EPA05323.1 - 0.0026 17.2 0.0 0.0051 16.2 0.0 1.5 1 0 0 1 1 1 1 ThiF family NAD_binding_2 PF03446.15 EPA05323.1 - 0.0057 16.8 0.0 0.092 12.9 0.0 2.5 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EPA05323.1 - 0.022 15.0 0.1 0.045 14.0 0.1 1.5 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase ApbA PF02558.16 EPA05323.1 - 0.12 12.0 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA SRR1 PF07985.12 EPA05323.1 - 0.15 12.1 0.0 0.39 10.8 0.0 1.6 1 0 0 1 1 1 0 SRR1 dTDP_sugar_isom PF00908.17 EPA05324.1 - 3e-70 235.3 0.0 3.4e-70 235.1 0.0 1.0 1 0 0 1 1 1 1 dTDP-4-dehydrorhamnose 3,5-epimerase NTP_transferase PF00483.23 EPA05326.1 - 9.8e-55 185.8 0.0 1.2e-54 185.5 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EPA05326.1 - 3.4e-08 34.0 0.0 4.4e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 EPA05326.1 - 3.8e-07 29.6 14.2 2.1e-05 24.1 3.7 3.6 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EPA05326.1 - 0.00021 20.4 2.5 0.00031 19.8 2.5 1.2 1 0 0 1 1 1 1 L-fucokinase Hexapep_2 PF14602.6 EPA05326.1 - 0.0067 16.1 5.1 0.0067 16.1 5.1 3.7 2 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase CTP_transf_3 PF02348.19 EPA05326.1 - 0.055 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase Methyltransf_21 PF05050.12 EPA05327.1 - 5.1e-23 82.0 0.6 7.7e-23 81.4 0.6 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain Met_10 PF02475.16 EPA05327.1 - 0.0015 18.3 0.8 0.0053 16.5 0.6 1.9 1 1 1 2 2 2 1 Met-10+ like-protein PCMT PF01135.19 EPA05327.1 - 0.0019 18.0 0.0 0.0031 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EPA05327.1 - 0.015 15.2 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.17 EPA05327.1 - 0.018 14.2 0.0 0.044 12.9 0.0 1.6 1 1 0 1 1 1 0 O-methyltransferase GATase PF00117.28 EPA05328.1 - 2.1e-15 57.0 0.0 2.9e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 EPA05328.1 - 4.4e-06 26.0 0.0 6.2e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 NAD synthase ThiI PF02568.14 EPA05328.1 - 0.00013 21.6 0.0 0.00019 21.1 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 EPA05328.1 - 0.00086 18.2 0.0 0.0011 17.8 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase Peptidase_C26 PF07722.13 EPA05328.1 - 0.0089 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 Proteasome PF00227.26 EPA05328.1 - 0.052 13.0 0.0 0.096 12.2 0.0 1.4 1 0 0 1 1 1 0 Proteasome subunit ATP_bind_3 PF01171.20 EPA05328.1 - 0.097 12.4 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 PP-loop family PAPS_reduct PF01507.19 EPA05328.1 - 0.12 12.4 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Hexapep PF00132.24 EPA05329.1 - 1.5e-11 43.5 11.2 3.1e-06 26.7 2.0 3.7 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EPA05329.1 - 3.9e-08 32.9 7.6 0.0017 18.0 4.2 3.7 3 1 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase Capsule_synth PF05159.14 EPA05332.1 - 2.7e-10 40.2 0.0 3e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Capsule polysaccharide biosynthesis protein SF3a60_bindingd PF12108.8 EPA05332.1 - 0.084 12.8 2.7 1.7 8.6 0.5 2.9 2 0 0 2 2 2 0 Splicing factor SF3a60 binding domain Methyltransf_23 PF13489.6 EPA05334.1 - 3.9e-16 59.3 0.0 6.5e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA05334.1 - 1.3e-12 48.3 0.0 2.5e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA05334.1 - 1.7e-08 35.0 0.0 2.5e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA05334.1 - 3.3e-08 33.5 0.0 4.8e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA05334.1 - 4.8e-07 30.4 0.0 9.5e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EPA05334.1 - 0.00051 19.7 0.0 0.00064 19.4 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CheR PF01739.18 EPA05334.1 - 0.0022 17.5 0.1 0.0055 16.2 0.0 1.6 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain CMAS PF02353.20 EPA05334.1 - 0.015 14.6 0.5 0.11 11.8 0.5 2.1 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.14 EPA05334.1 - 0.021 14.4 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_9 PF08003.11 EPA05334.1 - 0.028 13.4 0.1 0.12 11.3 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) Elf1 PF05129.13 EPA05334.1 - 0.047 13.8 0.8 0.12 12.5 0.8 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like DREV PF05219.12 EPA05334.1 - 0.053 12.6 0.0 0.21 10.6 0.0 1.7 1 1 0 2 2 2 0 DREV methyltransferase TackOD1 PF18551.1 EPA05334.1 - 0.079 12.6 1.2 0.16 11.7 1.2 1.5 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 Methyltransf_32 PF13679.6 EPA05334.1 - 0.08 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Zn_Tnp_IS1595 PF12760.7 EPA05334.1 - 0.2 11.7 0.9 0.38 10.8 0.9 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zinc_ribbon_5 PF13719.6 EPA05334.1 - 0.24 11.2 3.0 0.46 10.3 1.7 2.2 2 1 0 2 2 2 0 zinc-ribbon domain GDP_Man_Dehyd PF16363.5 EPA05335.1 - 1.4e-75 254.7 0.0 1.7e-75 254.5 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EPA05335.1 - 2.2e-56 191.0 0.0 2.8e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EPA05335.1 - 1.3e-18 67.0 0.3 1.6e-18 66.7 0.3 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EPA05335.1 - 6.7e-15 54.9 0.0 8.7e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EPA05335.1 - 3e-13 49.6 0.0 1.6e-12 47.2 0.0 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EPA05335.1 - 5.5e-11 42.1 0.1 8e-10 38.3 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein DUF4868 PF16162.5 EPA05335.1 - 0.048 13.6 0.3 0.048 13.6 0.3 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4868) Acetyltransf_1 PF00583.25 EPA05336.1 - 1.4e-13 51.1 0.1 1.9e-13 50.7 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 EPA05336.1 - 3.8e-10 40.6 0.1 4.7e-10 40.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EPA05336.1 - 4.3e-08 33.4 2.8 5.7e-08 33.0 2.8 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EPA05336.1 - 6.3e-07 29.7 0.4 9.3e-07 29.2 0.4 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EPA05336.1 - 7.8e-07 29.1 0.1 1.1e-06 28.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EPA05336.1 - 1.2e-06 28.4 0.0 2.6e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein GNAT_acetyltran PF12746.7 EPA05336.1 - 0.00018 21.2 1.0 0.0044 16.6 0.1 2.1 1 1 1 2 2 2 1 GNAT acetyltransferase Acetyltransf_8 PF13523.6 EPA05336.1 - 0.0062 16.2 0.0 0.0082 15.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Epimerase PF01370.21 EPA05337.1 - 4.6e-54 183.4 0.3 5.5e-54 183.2 0.3 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EPA05337.1 - 3.7e-50 171.2 2.4 1.5e-49 169.2 2.4 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EPA05337.1 - 7.1e-26 90.8 4.5 9.8e-26 90.4 4.5 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EPA05337.1 - 1e-18 67.5 5.0 5.2e-18 65.2 5.0 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EPA05337.1 - 3.2e-18 65.8 0.0 3.7e-18 65.6 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EPA05337.1 - 2.9e-12 46.3 0.8 4.2e-07 29.4 0.1 2.7 1 1 1 2 2 2 2 Male sterility protein KR PF08659.10 EPA05337.1 - 2.7e-08 33.9 0.0 6.8e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EPA05337.1 - 7e-08 32.6 0.0 1e-07 32.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EPA05337.1 - 1.1e-06 28.2 0.1 2e-06 27.4 0.1 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 EPA05337.1 - 0.00025 21.3 0.1 0.00056 20.2 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 EPA05337.1 - 0.00093 18.8 0.8 0.0023 17.5 0.2 1.9 2 0 0 2 2 2 1 NmrA-like family Shikimate_DH PF01488.20 EPA05337.1 - 0.0062 16.6 0.3 0.018 15.1 0.3 1.9 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EPA05337.1 - 0.015 15.6 1.5 0.029 14.6 0.5 2.2 2 1 0 2 2 2 0 TrkA-N domain adh_short_C2 PF13561.6 EPA05337.1 - 0.042 13.4 0.1 0.074 12.6 0.1 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase DapB_N PF01113.20 EPA05337.1 - 0.095 12.8 0.9 0.23 11.6 0.9 1.7 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus UDPGT PF00201.18 EPA05337.1 - 0.13 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase Pyr_redox PF00070.27 EPA05337.1 - 0.13 12.8 1.1 0.42 11.2 0.1 2.4 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase ACPS PF01648.20 EPA05338.1 - 4.5e-15 55.8 0.4 5.2e-15 55.6 0.4 1.0 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 EPA05338.1 - 0.13 12.4 0.0 0.4 10.8 0.0 1.7 1 1 0 1 1 1 0 4'-phosphopantetheinyl transferase N-terminal domain PMT_2 PF13231.6 EPA05339.1 - 1.7e-10 41.4 15.9 1.7e-10 41.4 15.9 2.9 3 1 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF2079 PF09852.9 EPA05339.1 - 0.00045 19.2 22.8 0.00045 19.2 22.8 1.6 1 1 0 1 1 1 1 Predicted membrane protein (DUF2079) PMT PF02366.18 EPA05339.1 - 0.0016 18.1 16.8 0.0058 16.3 16.8 2.0 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Phage_holin_5_2 PF16079.5 EPA05339.1 - 0.08 13.3 8.1 0.11 12.8 1.1 3.3 1 1 1 2 2 2 0 Phage holin family Hol44, in holin superfamily V NeuB PF03102.14 EPA05341.1 - 9.1e-19 67.9 0.3 1.1e-18 67.5 0.3 1.1 1 0 0 1 1 1 1 NeuB family DUF4839 PF16127.5 EPA05341.1 - 0.062 13.4 0.0 0.11 12.6 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4839) adh_short PF00106.25 EPA05342.1 - 2.1e-18 66.5 0.0 2.6e-18 66.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EPA05342.1 - 1.4e-15 57.5 0.0 2.3e-15 56.8 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Chorismate_bind PF00425.18 EPA05342.1 - 0.095 12.2 0.0 0.1 12.1 0.0 1.0 1 0 0 1 1 1 0 chorismate binding enzyme Glycos_transf_1 PF00534.20 EPA05343.1 - 1.3e-18 67.1 0.0 1.5e-18 66.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EPA05343.1 - 1.3e-12 48.3 0.0 1.6e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EPA05343.1 - 2e-06 28.1 0.0 2.5e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Acid_PPase PF12689.7 EPA05344.1 - 0.00017 21.4 4.6 0.0031 17.4 3.4 2.8 1 1 0 1 1 1 1 Acid Phosphatase Acetyltransf_4 PF13420.7 EPA05344.1 - 0.00094 19.3 0.5 0.0061 16.7 0.1 2.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain NIF PF03031.18 EPA05344.1 - 0.0026 17.5 0.1 0.0082 15.9 0.1 2.0 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Ribosomal_L22e PF01776.17 EPA05344.1 - 0.19 12.1 4.2 15 6.0 0.1 3.4 3 0 0 3 3 3 0 Ribosomal L22e protein family Glycos_transf_2 PF00535.26 EPA05345.1 - 1.2e-17 64.3 0.0 1.5e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_4 PF13704.6 EPA05345.1 - 0.015 15.8 0.0 0.03 14.8 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EPA05345.1 - 0.018 14.9 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 PP-binding PF00550.25 EPA05346.1 - 0.16 12.4 0.0 0.23 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphopantetheine attachment site RmlD_sub_bind PF04321.17 EPA05347.1 - 1.9e-71 240.5 0.0 2.2e-71 240.3 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EPA05347.1 - 7.5e-20 71.4 0.0 1.1e-19 70.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EPA05347.1 - 3e-11 43.3 0.1 2.9e-10 40.1 0.1 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EPA05347.1 - 9.9e-08 31.3 0.0 5.6e-07 28.8 0.0 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EPA05347.1 - 2.4e-07 30.2 0.2 8.5e-06 25.1 0.1 2.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EPA05347.1 - 5.1e-07 29.1 0.1 5.2e-05 22.5 0.0 2.7 1 1 0 2 2 2 1 Male sterility protein CTP_transf_3 PF02348.19 EPA05348.1 - 1.5e-20 74.1 0.1 2.1e-20 73.6 0.1 1.2 1 1 0 1 1 1 1 Cytidylyltransferase DUF2023 PF09633.10 EPA05348.1 - 0.0011 19.0 0.1 0.017 15.3 0.1 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF2023) NTP_transf_3 PF12804.7 EPA05348.1 - 0.0018 18.7 0.0 0.0021 18.4 0.0 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain KH_5 PF13184.6 EPA05348.1 - 0.0053 16.8 0.1 0.014 15.4 0.1 1.7 1 0 0 1 1 1 1 NusA-like KH domain Fungal_KA1 PF16797.5 EPA05349.1 - 0.095 12.4 0.0 0.095 12.4 0.0 1.0 1 0 0 1 1 1 0 Fungal kinase associated-1 domain MAF_flag10 PF01973.18 EPA05350.1 - 3.8e-19 69.0 0.1 7.9e-19 68.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF115 Asn_synthase PF00733.21 EPA05351.1 - 1.2e-06 28.5 0.0 1.4e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.16 EPA05351.1 - 0.01 14.7 0.0 0.013 14.3 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase ATP_bind_3 PF01171.20 EPA05351.1 - 0.029 14.1 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 PP-loop family CTP_transf_3 PF02348.19 EPA05352.1 - 1.3e-29 103.7 1.1 1.6e-29 103.4 1.1 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 EPA05352.1 - 0.00077 19.9 0.0 0.0012 19.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain PriA_3primeBD PF17764.1 EPA05352.1 - 0.32 10.9 2.4 1.2 9.0 0.1 2.6 3 0 0 3 3 3 0 3′ DNA-binding domain (3′BD) DegT_DnrJ_EryC1 PF01041.17 EPA05354.1 - 3.5e-87 293.0 0.0 4e-87 292.9 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EPA05354.1 - 7.6e-05 21.8 0.0 0.00014 21.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EPA05354.1 - 0.00081 18.7 0.0 0.0013 17.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II DUF1439 PF07273.12 EPA05354.1 - 0.066 13.0 0.2 0.21 11.4 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1439) MaoC_dehydratas PF01575.19 EPA05355.1 - 3.1e-21 75.2 0.0 3.8e-21 74.9 0.0 1.1 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EPA05355.1 - 5.1e-10 39.6 0.0 1.1e-09 38.5 0.0 1.5 1 1 0 1 1 1 1 N-terminal half of MaoC dehydratase 4HBT PF03061.22 EPA05355.1 - 0.056 13.8 0.0 0.084 13.2 0.0 1.3 1 0 0 1 1 1 0 Thioesterase superfamily Sipho_Gp37 PF14594.6 EPA05355.1 - 0.063 12.3 0.0 0.094 11.7 0.0 1.2 1 0 0 1 1 1 0 Siphovirus ReqiPepy6 Gp37-like protein AAA PF00004.29 EPA05356.1 - 4.6e-60 201.8 0.0 2.1e-43 147.9 0.0 2.2 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EPA05356.1 - 7.9e-13 48.0 0.0 1.8e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EPA05356.1 - 5e-08 33.5 0.1 2.8e-05 24.6 0.1 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EPA05356.1 - 2.2e-06 27.9 0.0 5.2e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EPA05356.1 - 7.3e-05 22.8 0.2 0.0031 17.5 0.1 3.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EPA05356.1 - 9.5e-05 22.7 0.1 0.0014 18.9 0.1 2.3 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 EPA05356.1 - 0.00013 21.3 0.0 0.00024 20.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EPA05356.1 - 0.00027 21.1 0.0 0.00052 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EPA05356.1 - 0.001 18.8 0.0 0.0034 17.1 0.0 1.9 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 EPA05356.1 - 0.0023 17.7 0.1 0.013 15.2 0.0 2.1 3 0 0 3 3 2 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 EPA05356.1 - 0.0075 16.0 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 EPA05356.1 - 0.0089 16.1 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 EPA05356.1 - 0.01 15.9 0.3 0.029 14.4 0.1 1.7 1 1 1 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EPA05356.1 - 0.018 14.9 0.1 0.28 11.1 0.2 2.2 1 1 0 2 2 2 0 NACHT domain PhoH PF02562.16 EPA05356.1 - 0.043 13.3 0.1 0.086 12.3 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein RNA_helicase PF00910.22 EPA05356.1 - 0.046 14.1 0.0 0.09 13.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 EPA05356.1 - 0.046 13.2 0.0 0.12 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region Bac_DnaA PF00308.18 EPA05356.1 - 0.047 13.5 0.1 1.3 8.9 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein Mg_chelatase PF01078.21 EPA05356.1 - 0.063 12.7 0.5 0.16 11.3 0.1 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EPA05356.1 - 0.092 12.1 0.0 0.41 9.9 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_28 PF13521.6 EPA05356.1 - 0.11 12.8 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EPA05356.1 - 0.11 13.0 0.2 0.39 11.3 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EPA05356.1 - 0.13 11.8 1.0 1.3 8.6 0.9 2.3 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EPA05356.1 - 0.13 12.7 0.0 0.27 11.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter CPT PF07931.12 EPA05356.1 - 0.14 12.0 0.0 0.37 10.6 0.0 1.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Cytidylate_kin PF02224.18 EPA05356.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase AAA_24 PF13479.6 EPA05356.1 - 0.17 11.6 0.0 0.37 10.5 0.0 1.6 2 0 0 2 2 1 0 AAA domain NB-ARC PF00931.22 EPA05356.1 - 0.18 11.0 0.1 0.48 9.6 0.1 1.7 2 0 0 2 2 2 0 NB-ARC domain DnaJ_C PF01556.18 EPA05358.1 - 1.3e-33 116.2 1.7 1.9e-33 115.6 1.7 1.2 1 1 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EPA05358.1 - 1.8e-13 50.7 19.6 3.6e-13 49.7 19.6 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EPA05358.1 - 0.39 10.7 20.6 2.3 8.3 6.0 3.2 1 1 3 4 4 4 0 Tryptophan RNA-binding attenuator protein inhibitory protein GatB_N PF02934.15 EPA05359.1 - 3.2e-61 207.1 0.1 5.8e-61 206.3 0.1 1.4 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EPA05359.1 - 4.9e-18 65.4 9.2 4.9e-18 65.4 9.2 2.0 2 0 0 2 2 2 1 GatB domain GAD PF02938.14 EPA05359.1 - 4.4e-09 36.5 1.3 7.3e-09 35.7 0.1 2.1 2 0 0 2 2 2 1 GAD domain RFC1 PF08519.12 EPA05359.1 - 0.1 12.8 1.8 0.34 11.1 1.2 2.3 1 1 1 2 2 2 0 Replication factor RFC1 C terminal domain p25-alpha PF05517.12 EPA05359.1 - 0.17 12.0 10.2 0.029 14.5 3.3 2.5 2 0 0 2 2 2 0 p25-alpha AAA_lid_3 PF17862.1 EPA05360.1 - 2.9e-10 39.8 0.2 6.6e-10 38.6 0.2 1.6 1 1 0 1 1 1 1 AAA+ lid domain NT5C PF06941.12 EPA05361.1 - 1.9e-13 50.7 1.7 2.4e-13 50.4 1.7 1.1 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Asparaginase PF00710.20 EPA05362.1 - 1.4e-53 181.3 0.1 2.2e-53 180.7 0.1 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EPA05362.1 - 1.5e-29 102.5 0.0 2.9e-29 101.6 0.0 1.5 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain GatD_N PF18195.1 EPA05362.1 - 5.8e-17 60.8 3.0 5.8e-17 60.8 3.0 2.2 3 0 0 3 3 3 1 GatD N-terminal domain KASH_CCD PF14662.6 EPA05363.1 - 0.011 15.6 0.3 0.012 15.4 0.3 1.0 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Retrotrans_gag PF03732.17 EPA05363.1 - 0.035 14.4 0.9 0.3 11.4 0.4 1.9 1 1 1 2 2 2 0 Retrotransposon gag protein Swi5 PF07061.11 EPA05363.1 - 0.046 13.8 1.4 0.07 13.2 1.4 1.3 1 0 0 1 1 1 0 Swi5 DUF1059 PF06348.11 EPA05364.1 - 6.3e-14 51.9 0.1 8.5e-14 51.5 0.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1059) DUF2653 PF10850.8 EPA05364.1 - 0.13 12.5 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2653) Pyr_redox_2 PF07992.14 EPA05365.1 - 1.9e-52 178.4 0.8 2.2e-52 178.2 0.8 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EPA05365.1 - 8.9e-26 90.8 3.5 1.2e-22 80.6 0.4 2.1 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EPA05365.1 - 1.9e-18 66.8 3.4 3.1e-17 62.9 0.2 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EPA05365.1 - 7.7e-07 28.5 2.1 0.0095 15.1 0.1 3.4 3 1 0 3 3 3 2 Glucose inhibited division protein A K_oxygenase PF13434.6 EPA05365.1 - 3e-05 23.3 0.1 0.16 11.1 0.0 3.2 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EPA05365.1 - 9.5e-05 22.1 2.3 0.033 13.8 0.0 2.9 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EPA05365.1 - 0.00015 21.2 1.0 0.12 11.6 0.1 2.7 2 1 1 3 3 3 2 FAD binding domain FAD_oxidored PF12831.7 EPA05365.1 - 0.00046 19.7 0.1 0.0012 18.3 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EPA05365.1 - 0.00051 19.4 0.0 0.0058 15.9 0.0 2.2 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 EPA05365.1 - 0.0006 19.0 3.8 0.0096 15.0 0.1 3.4 2 1 2 4 4 4 1 FAD binding domain NAD_binding_9 PF13454.6 EPA05365.1 - 0.0053 16.8 4.2 1.2 9.1 0.0 3.3 3 1 0 3 3 3 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EPA05365.1 - 0.0082 14.9 2.7 0.17 10.6 0.1 3.0 3 1 1 4 4 4 1 HI0933-like protein NAD_binding_7 PF13241.6 EPA05365.1 - 0.012 16.1 0.3 0.049 14.1 0.1 2.0 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_8 PF13450.6 EPA05365.1 - 0.012 15.9 0.4 0.044 14.0 0.1 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain MAF_flag10 PF01973.18 EPA05365.1 - 0.027 14.2 0.0 6.3 6.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function DUF115 NERD PF08378.11 EPA05366.1 - 0.12 12.9 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Nuclease-related domain zf-C2HC_2 PF13913.6 EPA05367.1 - 0.0095 15.8 0.2 0.0095 15.8 0.2 1.9 2 0 0 2 2 2 1 zinc-finger of a C2HC-type zf-C2H2_3 PF13878.6 EPA05367.1 - 0.023 14.5 1.0 0.55 10.1 0.1 2.2 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO ECM11 PF15463.6 EPA05367.1 - 0.032 14.8 0.1 0.034 14.7 0.1 1.1 1 0 0 1 1 1 0 Extracellular mutant protein 11 zf-RING_5 PF14634.6 EPA05367.1 - 0.041 13.8 2.8 2.2 8.3 0.3 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 EPA05367.1 - 0.054 13.5 1.2 2.3 8.3 0.1 2.2 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EPA05367.1 - 0.057 13.3 2.5 4.2 7.3 0.3 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Response_reg PF00072.24 EPA05369.1 - 1.3e-13 51.1 0.2 1.5e-13 50.9 0.2 1.1 1 0 0 1 1 1 1 Response regulator receiver domain DUF2584 PF10763.9 EPA05369.1 - 0.021 15.0 0.1 0.032 14.4 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2584) CNDH2_M PF16869.5 EPA05369.1 - 0.14 12.9 0.0 0.18 12.5 0.0 1.2 1 0 0 1 1 1 0 PF16858 MCPsignal PF00015.21 EPA05370.1 - 1.9e-08 34.3 3.2 3e-08 33.6 3.2 1.4 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain T3SS_needle_F PF09392.10 EPA05371.1 - 0.031 14.5 0.7 0.13 12.5 0.1 2.0 2 0 0 2 2 2 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF HTH_56 PF18662.1 EPA05373.1 - 0.013 15.5 2.9 0.016 15.3 2.9 1.1 1 0 0 1 1 1 0 Cch helix turn helix domain DUF1325 PF07039.11 EPA05373.1 - 0.019 15.0 1.2 0.022 14.9 1.2 1.1 1 0 0 1 1 1 0 SGF29 tudor-like domain Aurora-A_bind PF09041.10 EPA05373.1 - 0.12 12.5 1.2 0.48 10.5 0.2 2.1 2 0 0 2 2 2 0 Aurora-A binding HD_3 PF13023.6 EPA05374.1 - 1.5e-36 125.8 0.1 1.8e-36 125.6 0.1 1.0 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EPA05374.1 - 3e-16 59.7 0.7 5.7e-16 58.8 0.7 1.4 1 1 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 EPA05374.1 - 0.0046 17.2 0.0 0.01 16.1 0.0 1.6 1 1 0 1 1 1 1 HD domain BTG PF07742.12 EPA05374.1 - 0.057 13.3 0.1 0.087 12.7 0.1 1.4 1 0 0 1 1 1 0 BTG family DUF4130 PF13566.6 EPA05374.1 - 0.068 13.2 0.0 0.089 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4130 Cob_adeno_trans PF01923.18 EPA05375.1 - 1e-53 181.9 0.0 1.1e-53 181.7 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase ILVD_EDD PF00920.21 EPA05377.1 - 7.4e-40 137.0 0.0 8.1e-40 136.9 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family DUF4423 PF14394.6 EPA05380.1 - 4.6e-05 23.2 0.4 6.7e-05 22.7 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) HTH_45 PF14947.6 EPA05380.1 - 0.0016 18.3 0.2 0.0036 17.3 0.2 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix Rio2_N PF09202.11 EPA05380.1 - 0.0039 17.4 0.3 0.025 14.8 0.1 2.2 2 1 0 2 2 2 1 Rio2, N-terminal TFIIE_alpha PF02002.17 EPA05380.1 - 0.01 15.7 0.9 0.016 15.0 0.9 1.4 1 0 0 1 1 1 0 TFIIE alpha subunit TrmB PF01978.19 EPA05380.1 - 0.011 15.6 0.1 0.017 15.0 0.1 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.6 EPA05380.1 - 0.017 15.3 0.3 0.032 14.4 0.3 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain MarR_2 PF12802.7 EPA05380.1 - 0.091 12.7 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 MarR family DUF1676 PF07898.13 EPA05380.1 - 0.16 12.0 3.6 0.2 11.7 3.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1676) Abi_2 PF07751.11 EPA05380.1 - 0.18 12.0 0.5 0.25 11.6 0.5 1.2 1 0 0 1 1 1 0 Abi-like protein DUF3135 PF11333.8 EPA05380.1 - 0.19 12.0 0.3 0.19 12.0 0.3 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3135) Rieske PF00355.26 EPA05381.1 - 1.4e-14 53.7 0.0 1.6e-14 53.6 0.0 1.0 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 EPA05381.1 - 4.4e-13 49.1 0.0 5.1e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain AATF-Che1 PF13339.6 EPA05382.1 - 0.00098 19.8 3.3 0.0013 19.5 3.3 1.1 1 0 0 1 1 1 1 Apoptosis antagonizing transcription factor ALIX_LYPXL_bnd PF13949.6 EPA05382.1 - 0.013 14.9 2.1 0.016 14.6 2.1 1.0 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV CREPT PF16566.5 EPA05382.1 - 0.024 14.8 1.9 0.049 13.8 1.5 1.6 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Syntaxin-6_N PF09177.11 EPA05382.1 - 0.03 14.9 2.3 0.31 11.6 0.7 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal PH_4 PF15404.6 EPA05382.1 - 0.049 13.4 0.5 0.059 13.2 0.5 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain Snapin_Pallidin PF14712.6 EPA05382.1 - 0.059 13.8 1.5 0.12 12.8 1.1 1.8 1 1 0 1 1 1 0 Snapin/Pallidin DUF948 PF06103.11 EPA05382.1 - 0.062 13.6 0.1 1.9 8.8 0.1 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Epimerase PF01370.21 EPA05383.1 - 6e-23 81.5 0.0 7.8e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EPA05383.1 - 2e-18 66.9 0.0 4.9e-18 65.6 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EPA05383.1 - 2e-12 46.8 0.0 5.1e-06 25.8 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 EPA05383.1 - 4.9e-12 45.4 0.4 1.7e-11 43.7 0.4 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EPA05383.1 - 8.1e-08 31.7 0.0 4.5e-07 29.3 0.0 1.8 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EPA05383.1 - 2e-06 27.2 0.5 0.00024 20.4 0.5 2.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EPA05383.1 - 9.2e-06 25.7 0.0 1.5e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EPA05383.1 - 0.00021 20.9 0.1 0.00078 19.1 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family DUF1731 PF08338.11 EPA05383.1 - 0.019 14.8 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1731) PRTP PF01366.18 EPA05383.1 - 0.019 13.0 0.0 0.025 12.7 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Sarcolipin PF05366.11 EPA05383.1 - 0.043 13.5 0.1 0.084 12.6 0.1 1.4 1 0 0 1 1 1 0 Sarcolipin DUF3798 PF12683.7 EPA05383.1 - 0.11 11.9 0.0 0.27 10.6 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3798) adh_short PF00106.25 EPA05383.1 - 0.12 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase NAD_synthase PF02540.17 EPA05384.1 - 1.3e-76 256.9 1.4 1.6e-76 256.7 1.4 1.0 1 0 0 1 1 1 1 NAD synthase tRNA_Me_trans PF03054.16 EPA05384.1 - 0.00044 19.1 0.0 0.028 13.2 0.0 2.4 2 1 0 2 2 2 1 tRNA methyl transferase SpoIIID PF12116.8 EPA05384.1 - 0.0034 17.4 0.6 7.1 6.8 0.0 3.3 2 1 1 3 3 3 1 Stage III sporulation protein D QueC PF06508.13 EPA05384.1 - 0.0051 16.3 0.0 0.012 15.1 0.0 1.7 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC HTH_23 PF13384.6 EPA05384.1 - 0.006 16.3 0.0 5.3 7.0 0.0 2.6 2 0 0 2 2 2 2 Homeodomain-like domain ThiI PF02568.14 EPA05384.1 - 0.0076 15.9 0.1 0.061 12.9 0.0 2.2 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) Asn_synthase PF00733.21 EPA05384.1 - 0.0089 15.7 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Asparagine synthase RuvB_C PF05491.13 EPA05384.1 - 0.0092 15.8 3.8 6.5 6.7 0.0 3.4 2 1 1 3 3 3 1 RuvB C-terminal winged helix domain DNA_pol_B_exo2 PF10108.9 EPA05384.1 - 0.025 14.3 1.5 0.027 14.1 0.3 1.6 2 0 0 2 2 2 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB ATP_bind_3 PF01171.20 EPA05384.1 - 0.041 13.6 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 PP-loop family Peptidase_C25 PF01364.18 EPA05384.1 - 0.12 11.5 0.1 0.13 11.4 0.1 1.2 1 0 0 1 1 1 0 Peptidase family C25 Phage_terminase PF10668.9 EPA05384.1 - 0.27 11.3 1.3 1.3 9.1 0.2 2.5 2 2 1 3 3 3 0 Phage terminase small subunit AlphaC_C PF17480.2 EPA05384.1 - 1.1 9.3 5.9 0.52 10.4 0.4 2.6 2 0 0 2 2 2 0 AlphaC C-terminal TackOD1 PF18551.1 EPA05385.1 - 3.3e-31 108.4 13.4 5.5e-31 107.7 13.4 1.3 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 zinc-ribbons_6 PF07191.12 EPA05385.1 - 0.0004 20.3 19.0 0.07 13.1 2.7 3.8 3 1 1 4 4 4 3 zinc-ribbons DZR PF12773.7 EPA05385.1 - 0.00056 19.9 17.6 0.15 12.1 8.7 3.2 1 1 2 3 3 3 3 Double zinc ribbon Response_reg PF00072.24 EPA05385.1 - 0.0017 18.5 0.1 0.02 15.1 0.1 2.4 1 1 0 1 1 1 1 Response regulator receiver domain zf_UBZ PF18439.1 EPA05385.1 - 0.0073 15.9 19.2 0.5 10.0 0.4 4.8 4 1 1 5 5 5 2 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 EPA05385.1 - 0.0074 16.6 3.7 0.0074 16.6 3.7 2.6 1 1 1 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding DUF1610 PF07754.11 EPA05385.1 - 0.015 15.3 2.2 0.015 15.3 2.2 3.2 3 0 0 3 3 2 0 Domain of unknown function (DUF1610) HypA PF01155.19 EPA05385.1 - 0.035 14.1 17.0 0.21 11.6 1.8 3.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C3HC4_3 PF13920.6 EPA05385.1 - 0.049 13.5 13.2 2.2 8.2 1.0 3.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) FYVE_2 PF02318.16 EPA05385.1 - 0.066 13.4 14.1 0.23 11.7 5.2 2.3 1 1 1 2 2 2 0 FYVE-type zinc finger Terminase_2 PF03592.16 EPA05385.1 - 0.089 13.3 0.5 0.18 12.3 0.1 1.8 2 0 0 2 2 2 0 Terminase small subunit zf-CHY PF05495.12 EPA05385.1 - 0.099 13.2 16.8 4.2 7.9 11.5 3.3 1 1 1 2 2 2 0 CHY zinc finger zinc_ribbon_15 PF17032.5 EPA05385.1 - 0.12 13.1 15.7 0.62 10.8 0.2 3.4 2 1 1 3 3 3 0 zinc-ribbon family Spt4 PF06093.13 EPA05385.1 - 0.2 11.8 0.2 0.2 11.8 0.2 3.4 1 1 3 4 4 4 0 Spt4/RpoE2 zinc finger PhnA_Zn_Ribbon PF08274.12 EPA05385.1 - 0.49 10.4 18.0 1.5 8.8 0.4 4.6 4 1 0 4 4 4 0 PhnA Zinc-Ribbon zinc_ribbon_4 PF13717.6 EPA05385.1 - 1.6 8.7 20.7 0.31 11.0 0.3 5.1 5 0 0 5 5 5 0 zinc-ribbon domain zf-RING_4 PF14570.6 EPA05385.1 - 1.8 8.5 17.0 3.9 7.4 0.3 3.4 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-C2H2 PF00096.26 EPA05385.1 - 1.8 9.2 12.6 33 5.2 0.2 4.5 4 0 0 4 4 4 0 Zinc finger, C2H2 type Zn_Tnp_IS1595 PF12760.7 EPA05385.1 - 3.7 7.6 13.9 0.51 10.4 0.4 3.6 3 1 0 3 3 3 0 Transposase zinc-ribbon domain zf-C2H2_4 PF13894.6 EPA05385.1 - 5.3 8.1 16.6 27 6.0 0.2 4.8 5 0 0 5 5 5 0 C2H2-type zinc finger Prok-RING_1 PF14446.6 EPA05385.1 - 5.5 7.0 14.3 6.7 6.7 0.5 3.6 3 1 1 4 4 4 0 Prokaryotic RING finger family 1 Zn_ribbon_SprT PF17283.2 EPA05385.1 - 6.2 6.8 10.5 29 4.7 0.0 3.9 3 1 0 3 3 3 0 SprT-like zinc ribbon domain zf-RING_2 PF13639.6 EPA05385.1 - 6.6 7.2 15.1 10 6.6 0.1 3.3 3 0 0 3 3 3 0 Ring finger domain Response_reg PF00072.24 EPA05386.1 - 1.2e-18 67.3 0.5 1.3e-18 67.2 0.5 1.0 1 0 0 1 1 1 1 Response regulator receiver domain PrpR_N PF06506.11 EPA05386.1 - 0.0097 15.5 0.3 0.72 9.4 0.1 2.0 1 1 1 2 2 2 2 Propionate catabolism activator Phage_tail_U PF06141.11 EPA05386.1 - 0.088 13.2 0.1 4.5 7.6 0.0 2.2 2 0 0 2 2 2 0 Phage minor tail protein U AdoHcyase_NAD PF00670.21 EPA05387.1 - 4.5e-52 176.4 3.9 5.2e-52 176.2 0.8 2.2 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.17 EPA05387.1 - 9.8e-51 172.7 0.0 1.1e-24 87.1 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase 2-Hacid_dh_C PF02826.19 EPA05387.1 - 1.7e-09 37.3 0.1 4.3e-09 36.0 0.1 1.7 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EPA05387.1 - 2.1e-06 27.4 0.0 4.2e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EPA05387.1 - 0.0019 18.5 0.0 0.0068 16.7 0.0 1.9 2 0 0 2 2 2 1 TrkA-N domain Shikimate_DH PF01488.20 EPA05387.1 - 0.0036 17.4 0.7 0.086 12.9 0.1 2.7 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 EPA05387.1 - 0.0082 15.5 2.1 0.044 13.1 2.1 2.1 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 EPA05387.1 - 0.015 15.2 1.6 0.036 13.9 0.3 2.3 2 1 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 EPA05387.1 - 0.022 14.1 0.2 0.26 10.6 0.5 2.4 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain UDPG_MGDP_dh_N PF03721.14 EPA05387.1 - 0.068 12.7 0.2 0.15 11.6 0.2 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF364 PF04016.12 EPA05387.1 - 0.074 12.6 0.0 0.21 11.2 0.0 1.7 1 0 0 1 1 1 0 Putative heavy-metal chelation FUSC-like PF12805.7 EPA05388.1 - 0.058 12.5 0.1 0.065 12.3 0.1 1.2 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS CoA_binding_2 PF13380.6 EPA05389.1 - 1.9e-37 128.3 0.0 2.2e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.19 EPA05389.1 - 4.6e-07 30.4 0.0 8.2e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 CoA binding domain Glyco_hydro_57 PF03065.15 EPA05389.1 - 0.04 13.1 0.0 0.1 11.8 0.0 1.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 57 PAS_9 PF13426.7 EPA05391.1 - 1.1e-35 122.0 0.1 6.7e-17 61.7 0.0 3.0 2 0 0 2 2 2 2 PAS domain HATPase_c PF02518.26 EPA05391.1 - 2.9e-31 108.3 4.1 3.8e-31 107.9 0.9 2.8 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 EPA05391.1 - 1.4e-25 89.3 1.5 1e-12 48.2 0.1 2.8 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 EPA05391.1 - 6.1e-23 81.0 0.0 8.4e-11 41.9 0.0 2.8 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 EPA05391.1 - 7.1e-20 71.3 0.0 1.8e-09 37.8 0.0 2.5 2 0 0 2 2 2 2 PAS fold HisKA PF00512.25 EPA05391.1 - 1.3e-11 44.3 1.7 5.4e-11 42.4 0.0 2.7 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain dCache_1 PF02743.18 EPA05391.1 - 5e-10 39.6 22.9 2.8e-09 37.1 10.7 4.4 3 1 0 3 3 3 2 Cache domain PAS_8 PF13188.7 EPA05391.1 - 6.5e-09 35.6 0.0 0.00074 19.5 0.0 2.5 2 0 0 2 2 2 2 PAS domain HAMP PF00672.25 EPA05391.1 - 6.5e-08 32.8 0.3 2.5e-07 31.0 0.1 2.1 2 0 0 2 2 2 1 HAMP domain DUF2096 PF09869.9 EPA05391.1 - 0.0003 20.9 0.3 0.0015 18.7 0.3 2.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2096) HATPase_c_3 PF13589.6 EPA05391.1 - 0.00037 20.3 2.2 0.00055 19.8 0.2 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1397 PF07165.11 EPA05391.1 - 0.006 16.0 0.4 0.012 15.0 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1397) PAS_7 PF12860.7 EPA05391.1 - 0.16 12.1 2.0 32 4.7 0.0 4.0 3 1 0 3 3 3 0 PAS fold MMR_HSR1_C PF08438.10 EPA05392.1 - 4.8e-32 110.9 0.1 1.3e-31 109.5 0.0 1.7 2 0 0 2 2 2 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EPA05392.1 - 6.3e-19 68.1 0.0 6.4e-18 64.9 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 EPA05392.1 - 2.5e-07 30.7 0.0 4.9e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EPA05392.1 - 5.5e-05 22.7 0.1 0.0025 17.4 0.1 2.7 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EPA05392.1 - 0.00071 19.7 0.1 0.086 12.9 0.0 2.8 2 1 0 3 3 3 1 Dynamin family GTP_EFTU PF00009.27 EPA05392.1 - 0.028 14.0 0.8 9.8 5.7 0.0 2.9 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain BPL_LplA_LipB PF03099.19 EPA05393.1 - 8.3e-18 64.6 0.1 6.2e-17 61.7 0.0 2.0 2 0 0 2 2 2 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EPA05393.1 - 5.2e-08 32.7 0.9 1e-07 31.7 0.9 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain Sec15 PF04091.12 EPA05393.1 - 0.0067 15.9 0.1 0.0092 15.4 0.1 1.2 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like HTH_11 PF08279.12 EPA05393.1 - 0.038 13.9 0.6 0.14 12.1 0.6 2.0 1 0 0 1 1 1 0 HTH domain tRNA-synt_1g PF09334.11 EPA05394.1 - 7e-92 308.2 0.8 7.8e-92 308.0 0.8 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EPA05394.1 - 8.7e-15 54.0 0.9 8.3e-08 30.9 0.1 3.0 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EPA05394.1 - 4.1e-06 26.3 0.1 8.2e-06 25.4 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EPA05394.1 - 0.014 14.3 0.1 0.093 11.6 0.1 2.0 2 0 0 2 2 2 0 tRNA synthetases class I (K) PolC_DP2 PF03833.13 EPA05394.1 - 0.061 11.2 0.3 0.077 10.8 0.3 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-Di19 PF05605.12 EPA05394.1 - 0.12 12.7 2.3 0.27 11.5 2.3 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-CHY PF05495.12 EPA05394.1 - 0.33 11.5 3.7 0.67 10.5 3.7 1.6 1 0 0 1 1 1 0 CHY zinc finger zf-ribbon_3 PF13248.6 EPA05394.1 - 0.38 10.2 9.2 3.2 7.3 3.0 2.5 1 1 2 3 3 3 0 zinc-ribbon domain DZR PF12773.7 EPA05394.1 - 0.73 9.9 7.3 3.6 7.7 7.3 2.1 1 1 0 1 1 1 0 Double zinc ribbon HypA PF01155.19 EPA05394.1 - 3.6 7.7 4.4 47 4.0 0.0 2.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 EPA05394.1 - 8.1 6.7 8.5 0.85 9.8 1.9 2.3 1 1 1 2 2 2 0 Zinc ribbon domain DUF2975 PF11188.8 EPA05395.1 - 0.049 13.5 0.8 0.075 12.9 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) TPR_2 PF07719.17 EPA05396.1 - 2.7e-07 30.2 0.0 0.04 14.0 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EPA05396.1 - 3.6e-06 26.5 0.2 0.54 10.2 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat Coatomer_E PF04733.14 EPA05396.1 - 0.0023 17.4 0.1 0.0036 16.8 0.1 1.2 1 0 0 1 1 1 1 Coatomer epsilon subunit Porin_OmpG_1_2 PF16946.5 EPA05396.1 - 0.0026 17.1 0.2 0.0054 16.1 0.2 1.5 1 0 0 1 1 1 1 OMPG-porin 1 family DUF4919 PF16266.5 EPA05396.1 - 0.015 15.2 0.1 0.096 12.6 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4919) TPR_19 PF14559.6 EPA05396.1 - 0.015 15.8 0.0 0.21 12.1 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EPA05396.1 - 0.017 15.7 0.9 1.1 10.1 0.0 3.9 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EPA05396.1 - 0.04 14.7 0.0 7.3 7.7 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EPA05396.1 - 0.049 13.7 0.0 28 4.9 0.0 3.2 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EPA05396.1 - 0.1 13.1 0.0 0.24 11.8 0.0 1.6 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_8 PF13181.6 EPA05396.1 - 5.6 7.4 5.3 25 5.4 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Response_reg PF00072.24 EPA05397.1 - 2.1e-25 89.0 0.4 2.5e-25 88.8 0.4 1.1 1 0 0 1 1 1 1 Response regulator receiver domain Tafi-CsgC PF10610.9 EPA05397.1 - 0.097 12.9 0.0 6.8 7.0 0.0 2.2 1 1 1 2 2 2 0 Thin aggregative fimbriae synthesis protein AAA_14 PF13173.6 EPA05397.1 - 1.4 8.9 4.3 2.2 8.3 1.2 2.3 2 1 0 2 2 2 0 AAA domain tRNA-synt_1e PF01406.19 EPA05398.1 - 1.2e-125 418.8 1.3 1.2e-125 418.8 1.3 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EPA05398.1 - 1.6e-13 50.2 3.0 1.8e-08 33.6 1.2 2.6 2 1 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EPA05398.1 - 2.5e-08 32.7 0.1 7.7e-06 24.4 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) DALR_2 PF09190.11 EPA05398.1 - 9.9e-08 32.4 0.1 9.9e-08 32.4 0.1 2.1 2 0 0 2 2 2 1 DALR domain tRNA-synt_1f PF01921.18 EPA05398.1 - 7.4e-07 28.4 4.0 0.0014 17.6 0.0 2.6 3 1 0 3 3 3 2 tRNA synthetases class I (K) tRNA-synt_1c PF00749.21 EPA05398.1 - 3.6 6.4 10.1 0.77 8.6 3.1 3.0 3 1 0 3 3 3 0 tRNA synthetases class I (E and Q), catalytic domain TF_Zn_Ribbon PF08271.12 EPA05399.1 - 0.0013 18.2 0.6 0.0017 17.8 0.6 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding zinc_ribbon_10 PF10058.9 EPA05399.1 - 0.0014 18.3 1.1 0.0022 17.7 1.1 1.4 1 1 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein DpnI PF06044.12 EPA05399.1 - 0.006 16.2 0.9 0.0064 16.2 0.9 1.1 1 0 0 1 1 1 1 Dam-replacing family zf-4CXXC_R1 PF10497.9 EPA05399.1 - 0.0074 16.5 0.9 0.0079 16.4 0.9 1.1 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 C1_1 PF00130.22 EPA05399.1 - 0.015 15.1 1.3 0.022 14.6 1.3 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HNH_5 PF14279.6 EPA05399.1 - 0.017 14.9 3.9 0.18 11.7 0.4 2.1 1 1 1 2 2 2 0 HNH endonuclease DZR PF12773.7 EPA05399.1 - 0.018 15.1 0.9 0.027 14.5 0.9 1.4 1 1 0 1 1 1 0 Double zinc ribbon Enterotoxin_ST PF02048.16 EPA05399.1 - 0.022 15.2 1.4 0.03 14.8 1.4 1.2 1 0 0 1 1 1 0 Heat-stable enterotoxin ST zf_UBZ PF18439.1 EPA05399.1 - 0.041 13.5 1.0 3.9 7.2 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger GATA PF00320.27 EPA05399.1 - 0.047 13.3 5.7 0.061 12.9 5.7 1.2 1 0 0 1 1 1 0 GATA zinc finger zf-B_box PF00643.24 EPA05399.1 - 0.059 13.5 1.3 3.2 8.0 0.1 2.1 2 0 0 2 2 2 0 B-box zinc finger DUF3268 PF11672.8 EPA05399.1 - 0.079 13.3 1.1 0.94 9.8 0.1 2.0 1 1 0 2 2 2 0 zinc-finger-containing domain zf-UBP PF02148.19 EPA05399.1 - 0.11 12.9 3.2 0.17 12.2 3.3 1.3 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein PHD PF00628.29 EPA05399.1 - 0.2 11.6 6.1 4.4 7.3 6.1 2.1 1 1 0 1 1 1 0 PHD-finger Prim_Zn_Ribbon PF08273.12 EPA05399.1 - 0.21 11.9 4.6 0.49 10.7 0.4 2.1 1 1 1 2 2 2 0 Zinc-binding domain of primase-helicase PHD_2 PF13831.6 EPA05399.1 - 0.21 11.2 5.3 1.6 8.3 1.5 2.2 2 0 0 2 2 2 0 PHD-finger RNA_POL_M_15KD PF02150.16 EPA05399.1 - 0.41 10.6 5.5 0.94 9.4 5.1 1.7 1 1 1 2 2 2 0 RNA polymerases M/15 Kd subunit Fer4 PF00037.27 EPA05400.1 - 5.2e-08 32.4 16.0 0.00016 21.4 3.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 EPA05400.1 - 1.5e-05 25.1 3.9 2.6e-05 24.3 3.9 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EPA05400.1 - 1.7e-05 25.3 4.9 7.8e-05 23.2 5.6 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EPA05400.1 - 5.2e-05 23.3 6.1 0.00012 22.2 6.1 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 EPA05400.1 - 0.00026 21.1 3.7 0.00043 20.3 3.7 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain ETF_QO PF05187.13 EPA05400.1 - 0.00078 19.5 0.6 0.0015 18.7 0.6 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_6 PF12837.7 EPA05400.1 - 0.0033 17.4 13.1 0.0048 16.9 1.6 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain Tenui_PVC2 PF06656.11 EPA05400.1 - 0.0063 14.5 0.1 0.0088 14.0 0.1 1.1 1 0 0 1 1 1 1 Tenuivirus PVC2 protein Fer4_17 PF13534.6 EPA05400.1 - 0.018 15.6 1.6 9.2 6.9 0.9 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain Me-amine-dh_L PF02975.14 EPA05400.1 - 0.088 13.3 2.1 0.16 12.5 2.1 1.3 1 0 0 1 1 1 0 Methylamine dehydrogenase, L chain Fer4_16 PF13484.6 EPA05400.1 - 0.18 12.7 8.1 2.7 9.0 2.6 2.7 1 1 1 2 2 2 0 4Fe-4S double cluster binding domain Fer4_8 PF13183.6 EPA05400.1 - 0.19 12.2 5.1 4.6 7.8 6.1 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 EPA05400.1 - 1.1 9.5 3.7 5.1 7.3 0.3 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 EPA05400.1 - 2.3 8.5 9.4 4.7 7.5 0.4 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_13 PF13370.6 EPA05400.1 - 2.6 8.7 9.5 0.53 10.9 0.6 2.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 EPA05400.1 - 2.6 9.2 14.2 11 7.3 5.3 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain DUF1664 PF07889.12 EPA05401.1 - 1.6e-05 24.9 39.6 0.0064 16.5 1.9 5.9 1 1 4 5 5 5 4 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 EPA05401.1 - 2.6e-05 24.6 39.9 0.3 11.6 1.0 6.5 1 1 2 5 5 5 3 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 EPA05401.1 - 0.00028 21.1 2.3 0.00028 21.1 2.3 5.0 1 1 3 5 5 5 1 Fibrinogen alpha/beta chain family DUF948 PF06103.11 EPA05401.1 - 0.00047 20.4 32.4 0.17 12.1 0.8 6.2 1 1 2 4 4 4 2 Bacterial protein of unknown function (DUF948) Snapin_Pallidin PF14712.6 EPA05401.1 - 0.00087 19.7 35.9 0.52 10.8 2.0 6.3 3 2 3 6 6 6 2 Snapin/Pallidin BLOC1_2 PF10046.9 EPA05401.1 - 0.001 19.3 45.1 0.067 13.5 1.6 7.2 1 1 6 7 7 7 3 Biogenesis of lysosome-related organelles complex-1 subunit 2 DHR10 PF18595.1 EPA05401.1 - 0.0032 17.5 1.3 0.0032 17.5 1.3 5.0 2 2 3 5 5 5 1 Designed helical repeat protein 10 domain ATG16 PF08614.11 EPA05401.1 - 0.028 14.7 28.3 0.5 10.6 7.7 4.3 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) HSBP1 PF06825.12 EPA05401.1 - 0.037 13.9 19.9 0.48 10.3 0.0 6.1 5 1 1 6 6 5 0 Heat shock factor binding protein 1 kleA_kleC PF17383.2 EPA05401.1 - 0.079 13.3 1.4 18 5.7 0.1 4.1 3 1 0 4 4 4 0 Uncharacterized KorC regulated protein A Serine_rich PF08824.10 EPA05401.1 - 0.11 12.5 23.0 0.08 12.9 2.4 4.9 2 2 2 4 4 4 0 Serine rich protein interaction domain Laminin_I PF06008.14 EPA05401.1 - 0.13 12.0 34.1 0.27 10.9 2.5 4.1 1 1 3 4 4 4 0 Laminin Domain I DUF3540 PF12059.8 EPA05401.1 - 0.18 11.6 5.7 1.1 9.1 0.3 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3540) DUF3450 PF11932.8 EPA05401.1 - 0.2 11.0 35.3 0.31 10.3 9.8 4.6 2 2 2 4 4 4 0 Protein of unknown function (DUF3450) Sec34 PF04136.15 EPA05401.1 - 0.22 11.4 32.4 0.22 11.4 2.7 6.2 1 1 4 6 6 6 0 Sec34-like family Cauli_AT PF03233.13 EPA05401.1 - 0.25 11.2 39.8 0.39 10.6 0.4 5.2 2 2 3 5 5 5 0 Aphid transmission protein DUF4088 PF13317.6 EPA05401.1 - 0.42 10.1 3.5 0.51 9.9 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4088) GIT1_C PF12205.8 EPA05401.1 - 0.44 10.7 25.3 0.29 11.2 2.8 4.6 3 1 1 4 4 3 0 G protein-coupled receptor kinase-interacting protein 1 C term MCPsignal PF00015.21 EPA05401.1 - 0.51 10.1 38.5 0.73 9.6 3.4 5.3 1 1 4 5 5 5 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Laminin_II PF06009.12 EPA05401.1 - 0.52 10.3 43.0 0.04 13.9 10.2 4.9 1 1 3 4 4 4 0 Laminin Domain II TolA_bind_tri PF16331.5 EPA05401.1 - 0.64 10.1 19.6 1.3 9.1 0.5 5.8 4 2 2 6 6 5 0 TolA binding protein trimerisation FlaC_arch PF05377.11 EPA05401.1 - 0.86 10.1 34.5 0.4 11.1 0.4 7.8 4 2 5 9 9 8 0 Flagella accessory protein C (FlaC) HD_4 PF13328.6 EPA05401.1 - 1 9.1 6.2 0.53 10.0 0.9 2.9 2 1 1 3 3 3 0 HD domain HrpB7 PF09486.10 EPA05401.1 - 1.3 9.4 5.2 9.4 6.6 1.4 3.8 2 1 3 5 5 5 0 Bacterial type III secretion protein (HrpB7) Cas_Cmr5 PF09701.10 EPA05401.1 - 1.3 9.3 6.2 0.59 10.4 1.0 3.1 2 1 0 2 2 2 0 CRISPR-associated protein (Cas_Cmr5) Occludin_ELL PF07303.13 EPA05401.1 - 2 9.2 22.6 1.5 9.6 0.1 5.2 2 2 3 5 5 5 0 Occludin homology domain CCDC-167 PF15188.6 EPA05401.1 - 2.1 8.7 25.2 0.19 12.1 0.4 5.7 4 2 2 6 6 6 0 Coiled-coil domain-containing protein 167 SesA PF17107.5 EPA05401.1 - 2.4 8.4 26.8 6.1 7.1 2.1 4.8 2 1 2 4 4 4 0 N-terminal domain on NACHT_NTPase and P-loop NTPases RPW8 PF05659.11 EPA05401.1 - 2.8 7.6 26.9 4.7 6.9 1.5 6.0 1 1 4 6 6 6 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF745 PF05335.13 EPA05401.1 - 4.6 6.9 24.5 0.35 10.6 1.7 4.2 1 1 3 4 4 4 0 Protein of unknown function (DUF745) eIF3_N PF09440.10 EPA05401.1 - 5.5 7.4 28.3 1.2 9.6 4.4 5.1 2 2 2 4 4 3 0 eIF3 subunit 6 N terminal domain DUF3365 PF11845.8 EPA05401.1 - 6.1 7.1 7.1 0.97 9.7 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3365) DUF2730 PF10805.8 EPA05401.1 - 6.5 6.9 22.7 5.8 7.1 1.2 5.5 2 2 4 6 6 6 0 Protein of unknown function (DUF2730) FliT PF05400.13 EPA05401.1 - 8.2 7.3 14.9 1.4 9.7 3.2 4.8 2 2 2 5 5 5 0 Flagellar protein FliT Fez1 PF06818.15 EPA05401.1 - 8.6 6.8 33.7 6 7.3 8.8 3.7 1 1 2 3 3 3 0 Fez1 Osmo_CC PF08946.10 EPA05401.1 - 8.9 6.7 10.3 35 4.7 0.1 5.2 4 1 1 5 5 5 0 Osmosensory transporter coiled coil ERCC4 PF02732.15 EPA05402.1 - 4.2e-23 82.3 0.0 6.9e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain HHH_5 PF14520.6 EPA05402.1 - 1.8e-09 38.0 0.0 1.9e-08 34.8 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH PF00633.23 EPA05402.1 - 6.1e-07 29.0 0.0 0.0093 15.8 0.0 2.5 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_2 PF12826.7 EPA05402.1 - 4e-05 23.6 0.0 0.00011 22.2 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_3 PF12836.7 EPA05402.1 - 8.3e-05 22.8 0.0 0.015 15.6 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif 5_3_exonuc PF01367.20 EPA05402.1 - 0.0041 17.7 0.1 0.011 16.3 0.1 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_8 PF14716.6 EPA05402.1 - 0.01 16.2 0.1 1.4 9.4 0.0 2.4 1 1 1 2 2 2 0 Helix-hairpin-helix domain DUF4284 PF14112.6 EPA05403.1 - 0.15 13.0 0.9 0.22 12.5 0.1 1.6 2 0 0 2 2 2 0 Immunity protein 22 Pcc1 PF09341.10 EPA05404.1 - 3.3e-06 27.2 0.0 3.4e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 tRNA_int_endo PF01974.17 EPA05405.1 - 1.7e-19 69.7 0.3 3.2e-19 68.8 0.1 1.6 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EPA05405.1 - 3.1e-13 49.2 4.5 1.1e-12 47.4 1.1 2.3 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain Spore_YabQ PF09578.10 EPA05406.1 - 0.00022 21.4 1.7 0.00023 21.3 0.8 1.5 2 0 0 2 2 2 1 Spore cortex protein YabQ (Spore_YabQ) Spore-coat_CotZ PF10612.9 EPA05407.1 - 0.048 13.8 0.0 0.05 13.8 0.0 1.1 1 0 0 1 1 1 0 Spore coat protein Z Ribosomal_L16 PF00252.18 EPA05408.1 - 1.9e-24 86.1 0.3 2.3e-24 85.9 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e RNA_pol_A_bac PF01000.26 EPA05409.1 - 7.4e-25 87.5 0.0 1.4e-24 86.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EPA05409.1 - 1.8e-14 52.9 0.0 2.2e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF2401 PF10287.9 EPA05409.1 - 0.042 13.4 0.2 0.063 12.9 0.2 1.2 1 0 0 1 1 1 0 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF1492 PF07374.11 EPA05410.1 - 0.26 11.5 2.7 0.28 11.3 1.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1492) NAD_kinase PF01513.21 EPA05411.1 - 5.1e-35 121.1 0.4 7e-35 120.6 0.4 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EPA05411.1 - 2.7e-06 27.0 0.0 5.1e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain CoA_binding_2 PF13380.6 EPA05411.1 - 0.0019 18.7 0.0 0.0036 17.8 0.0 1.6 1 0 0 1 1 1 1 CoA binding domain RNase_PH PF01138.21 EPA05412.1 - 1.2e-20 74.4 0.0 2.2e-20 73.5 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EPA05412.1 - 1.5e-14 53.7 1.9 1.7e-14 53.6 0.1 2.1 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 SBBP PF06739.11 EPA05412.1 - 9.9 6.3 11.3 8.4 6.5 0.9 3.2 3 0 0 3 3 3 0 Beta-propeller repeat Na_H_Exchanger PF00999.21 EPA05413.1 - 1.1e-38 133.0 43.6 1.4e-38 132.7 43.6 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family RecR PF02132.15 EPA05414.1 - 0.0019 17.7 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 RecR protein DNA_ligase_ZBD PF03119.16 EPA05414.1 - 0.006 16.6 1.6 0.13 12.3 0.1 2.2 2 0 0 2 2 2 1 NAD-dependent DNA ligase C4 zinc finger domain DZR PF12773.7 EPA05414.1 - 0.0065 16.5 2.3 0.014 15.4 2.3 1.4 1 1 0 1 1 1 1 Double zinc ribbon zf-C3HC4_3 PF13920.6 EPA05414.1 - 0.0069 16.2 1.1 0.0091 15.8 1.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) tRNA-synt_1g PF09334.11 EPA05414.1 - 0.0082 14.9 0.2 0.0082 14.9 0.2 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (M) zf-TFIIB PF13453.6 EPA05414.1 - 0.013 14.8 2.1 2.3 7.6 0.3 2.2 2 0 0 2 2 2 0 Transcription factor zinc-finger zinc-ribbons_6 PF07191.12 EPA05414.1 - 0.015 15.3 0.2 0.017 15.1 0.2 1.1 1 0 0 1 1 1 0 zinc-ribbons NOB1_Zn_bind PF08772.11 EPA05414.1 - 0.015 15.4 0.4 0.017 15.3 0.4 1.2 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Auto_anti-p27 PF06677.12 EPA05414.1 - 0.033 14.4 5.5 0.17 12.1 1.9 2.4 2 1 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Nudix_N_2 PF14803.6 EPA05414.1 - 0.039 13.9 0.1 0.039 13.9 0.1 2.4 2 1 0 2 2 2 0 Nudix N-terminal zinc_ribbon_2 PF13240.6 EPA05414.1 - 0.065 13.0 5.5 0.31 10.8 0.4 2.2 2 0 0 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 EPA05414.1 - 0.07 13.1 2.0 0.16 11.9 0.8 1.8 1 1 1 2 2 2 0 Putative transposase DNA-binding domain UPF0547 PF10571.9 EPA05414.1 - 0.15 12.2 4.0 2 8.6 0.4 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Zn_ribbon_SprT PF17283.2 EPA05414.1 - 0.17 11.8 5.9 1.7 8.6 5.9 2.0 1 1 0 1 1 1 0 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 EPA05414.1 - 0.23 11.6 5.0 1.4 9.1 0.4 2.1 1 1 1 2 2 2 0 Zinc ribbon domain Rad50_zn_hook PF04423.14 EPA05414.1 - 0.31 10.9 0.3 0.31 10.9 0.3 1.7 1 1 1 2 2 2 0 Rad50 zinc hook motif DUF2752 PF10825.8 EPA05414.1 - 4.8 7.3 10.2 3.9 7.6 4.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2752) SBDS PF01172.18 EPA05415.1 - 7.8e-23 80.4 0.1 2e-22 79.1 0.1 1.7 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 EPA05415.1 - 2.2e-18 66.4 0.3 7.3e-18 64.7 0.1 1.8 2 0 0 2 2 2 1 SBDS protein C-terminal domain EFG_C PF00679.24 EPA05415.1 - 0.031 14.3 0.0 0.056 13.5 0.0 1.4 1 0 0 1 1 1 0 Elongation factor G C-terminus PIN_6 PF17146.4 EPA05416.1 - 0.048 14.2 0.0 0.058 13.9 0.0 1.1 1 0 0 1 1 1 0 PIN domain of ribonuclease Glyco_tranf_2_3 PF13641.6 EPA05417.1 - 6.1e-23 81.9 0.0 9.9e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EPA05417.1 - 5.2e-19 68.9 0.6 9.3e-19 68.1 0.6 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EPA05417.1 - 8.7e-18 64.7 0.0 1.5e-17 63.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EPA05417.1 - 1.7e-11 43.9 0.1 3e-11 43.1 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 EPA05417.1 - 0.1 13.1 0.0 0.73 10.4 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 2 Rhodanese PF00581.20 EPA05418.1 - 1.3e-15 57.8 0.0 6.7e-15 55.5 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain DUF412 PF04217.13 EPA05418.1 - 0.051 13.5 0.0 0.086 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF412 Aconitase_C PF00694.19 EPA05419.1 - 1.1e-20 74.4 0.2 6.8e-20 71.7 0.0 2.2 2 1 0 2 2 2 1 Aconitase C-terminal domain Aconitase_2_N PF06434.13 EPA05419.1 - 0.002 17.8 0.2 0.0085 15.7 0.2 1.9 1 1 0 1 1 1 1 Aconitate hydratase 2 N-terminus Aconitase PF00330.20 EPA05420.1 - 6.3e-36 124.4 0.8 1.1e-33 117.0 0.8 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) DUF521 PF04412.13 EPA05420.1 - 0.06 12.0 0.0 0.083 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) RNase_PH PF01138.21 EPA05421.1 - 2.1e-34 118.9 0.0 2.8e-34 118.4 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EPA05421.1 - 4.4e-12 45.9 0.1 1e-11 44.7 0.1 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 AIM24 PF01987.17 EPA05422.1 - 2e-53 181.2 0.2 2.3e-53 181.0 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 KH_6 PF15985.5 EPA05423.1 - 2e-07 31.2 0.0 3.3e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 KH domain KH_1 PF00013.29 EPA05423.1 - 2.9e-07 30.2 0.2 6e-07 29.2 0.2 1.5 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 EPA05423.1 - 0.00021 21.0 0.1 0.00042 20.1 0.1 1.5 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 EPA05423.1 - 0.02 14.8 0.1 0.074 12.9 0.0 2.0 1 1 1 2 2 2 0 KH domain TAF PF02969.17 EPA05423.1 - 0.065 13.4 0.3 2.3 8.5 0.0 2.3 2 0 0 2 2 2 0 TATA box binding protein associated factor (TAF) Ribosomal_L13 PF00572.18 EPA05424.1 - 2.7e-12 47.0 0.4 3.1e-10 40.4 0.3 2.2 1 1 0 1 1 1 1 Ribosomal protein L13 Rhodanese PF00581.20 EPA05425.1 - 2.4e-35 121.3 0.4 4.6e-18 65.7 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain Ribosomal_S9 PF00380.19 EPA05427.1 - 4.6e-34 117.5 0.2 5.3e-34 117.4 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 NFACT-R_1 PF05670.13 EPA05427.1 - 0.024 15.3 0.0 0.034 14.8 0.0 1.2 1 0 0 1 1 1 0 NFACT protein RNA binding domain Prefoldin_2 PF01920.20 EPA05428.1 - 1.5e-21 76.3 20.6 1.8e-21 76.1 20.6 1.0 1 0 0 1 1 1 1 Prefoldin subunit FapA PF03961.13 EPA05428.1 - 3.7 6.1 11.3 5 5.6 11.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Vir_act_alpha_C PF10400.9 EPA05428.1 - 6.8 7.5 10.4 0.41 11.4 1.8 2.3 1 1 1 2 2 2 0 Virulence activator alpha C-term Macoilin PF09726.9 EPA05428.1 - 7.6 5.0 11.9 9.4 4.6 11.9 1.0 1 0 0 1 1 1 0 Macoilin family Aconitase PF00330.20 EPA05429.1 - 4.6e-54 184.1 0.1 5.9e-54 183.8 0.1 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Ribosomal_L18 PF17135.4 EPA05431.1 - 1.8e-07 30.8 0.0 1.9e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EPA05431.1 - 0.00053 20.7 0.1 0.00073 20.2 0.1 1.4 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A NTP_transferase PF00483.23 EPA05432.1 - 9.1e-19 68.0 0.1 1.1e-18 67.7 0.1 1.0 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EPA05432.1 - 3.1e-10 40.6 0.0 3.6e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 EPA05432.1 - 0.084 12.6 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Vps36-NZF-N PF16988.5 EPA05433.1 - 0.011 15.1 1.8 0.027 13.9 1.9 1.6 1 1 1 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-C4pol PF14260.6 EPA05433.1 - 0.014 15.8 0.5 0.016 15.7 0.5 1.1 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta LIM PF00412.22 EPA05433.1 - 0.054 13.7 0.2 0.061 13.6 0.2 1.1 1 0 0 1 1 1 0 LIM domain Ribosomal_L37ae PF01780.19 EPA05434.1 - 4.2e-19 68.4 1.9 4.6e-19 68.3 1.9 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 EPA05434.1 - 0.00023 21.1 5.1 0.00028 20.8 3.1 1.9 2 0 0 2 2 2 1 Transposase zinc-ribbon domain C1_1 PF00130.22 EPA05434.1 - 0.014 15.3 2.3 0.018 14.9 2.3 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) OrfB_Zn_ribbon PF07282.11 EPA05434.1 - 0.019 14.9 3.3 0.034 14.1 3.3 1.7 1 1 0 1 1 1 0 Putative transposase DNA-binding domain TF_Zn_Ribbon PF08271.12 EPA05434.1 - 0.044 13.3 1.6 0.075 12.6 1.6 1.4 1 1 0 1 1 1 0 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 EPA05434.1 - 0.059 13.5 0.3 0.059 13.5 0.3 2.0 1 1 1 2 2 2 0 Zinc ribbon domain DUF1451 PF07295.11 EPA05434.1 - 0.74 9.8 4.1 0.55 10.3 0.8 1.9 1 1 1 2 2 2 0 Zinc-ribbon containing domain Aconitase PF00330.20 EPA05435.1 - 2.6e-153 511.3 0.0 3e-153 511.1 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EPA05438.1 - 4.7e-37 127.3 0.0 8.2e-37 126.5 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase_2_N PF06434.13 EPA05438.1 - 0.00013 21.6 0.2 0.0053 16.4 0.2 2.1 1 1 0 1 1 1 1 Aconitate hydratase 2 N-terminus SBP_bac_5 PF00496.22 EPA05439.1 - 1.1e-08 34.5 3.2 2.2e-05 23.6 0.0 3.1 3 0 0 3 3 3 3 Bacterial extracellular solute-binding proteins, family 5 Middle PBP PF01161.20 EPA05440.1 - 2.9e-38 131.2 0.0 3.3e-38 131.0 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PIN_9 PF18477.1 EPA05442.1 - 2.6e-10 40.6 0.0 2.9e-10 40.4 0.0 1.0 1 0 0 1 1 1 1 PIN like domain Fcf1 PF04900.12 EPA05442.1 - 1.6e-05 25.2 0.0 2e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Fcf1 BRCT PF00533.26 EPA05442.1 - 0.02 15.3 0.4 0.064 13.6 0.1 2.0 1 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain eIF2_C PF09173.11 EPA05443.1 - 1.6e-25 89.2 0.2 1.3e-24 86.3 0.1 2.2 2 0 0 2 2 2 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.25 EPA05443.1 - 1.4e-06 28.5 0.9 2.7e-06 27.7 0.3 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1_Xtn PF16897.5 EPA05443.1 - 0.0035 17.3 0.0 0.01 15.8 0.0 1.8 1 1 1 2 2 2 1 C-terminal region of MMR_HSR1 domain GTP_EFTU PF00009.27 EPA05443.1 - 0.0044 16.6 0.0 0.0063 16.1 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain ProQ_C PF17516.2 EPA05443.1 - 0.052 13.0 0.0 0.16 11.4 0.0 1.8 2 0 0 2 2 2 0 ProQ C-terminal domain Usp PF00582.26 EPA05444.1 - 4.1e-18 66.2 0.0 4.9e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family Zf_RING PF16744.5 EPA05446.1 - 0.066 13.3 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 KIAA1045 RING finger HEPN_RiboL-PSP PF18735.1 EPA05446.1 - 1.8 8.5 12.2 3.1 7.7 11.4 1.8 1 1 0 1 1 1 0 RiboL-PSP-HEPN Response_reg PF00072.24 EPA05447.1 - 7.1e-16 58.4 0.2 1e-15 57.9 0.2 1.2 1 0 0 1 1 1 1 Response regulator receiver domain TIR-like PF10137.9 EPA05447.1 - 0.023 14.7 0.6 0.16 12.0 0.0 2.1 2 1 0 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain RNA_binding PF01877.17 EPA05447.1 - 0.038 14.3 0.1 0.093 13.0 0.0 1.7 1 1 0 1 1 1 0 RNA binding PPP1R35_C PF15503.6 EPA05447.1 - 0.062 13.1 0.1 0.089 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 35 C-terminus ATPase PF06745.13 EPA05448.1 - 1.5e-18 67.0 0.7 1.8e-18 66.7 0.7 1.0 1 0 0 1 1 1 1 KaiC Rad51 PF08423.11 EPA05448.1 - 1.5e-06 27.6 0.0 2.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Rad51 DUF835 PF05763.12 EPA05448.1 - 0.00022 20.9 2.9 0.00049 19.9 2.9 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF835) PAXNEB PF05625.11 EPA05448.1 - 0.0011 18.2 1.9 0.71 8.9 0.0 2.1 1 1 0 2 2 2 2 PAXNEB protein NACHT PF05729.12 EPA05448.1 - 0.0011 18.9 0.1 0.0077 16.2 0.1 2.0 1 1 0 1 1 1 1 NACHT domain DUF2075 PF09848.9 EPA05448.1 - 0.0019 17.5 0.0 0.0024 17.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 EPA05448.1 - 0.0029 17.5 0.8 0.0041 17.1 0.8 1.1 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Elong_Iki1 PF10483.9 EPA05448.1 - 0.0036 16.9 0.6 0.0045 16.5 0.6 1.3 1 0 0 1 1 1 1 Elongator subunit Iki1 AAA_16 PF13191.6 EPA05448.1 - 0.0036 17.7 0.0 0.0049 17.3 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 EPA05448.1 - 0.0054 16.5 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_22 PF13401.6 EPA05448.1 - 0.0056 17.0 0.0 0.0084 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EPA05448.1 - 0.0084 15.5 0.0 0.012 15.0 0.0 1.4 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_14 PF13173.6 EPA05448.1 - 0.012 15.6 2.1 0.41 10.7 2.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EPA05448.1 - 0.016 14.8 0.0 0.12 11.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EPA05448.1 - 0.02 15.5 0.2 0.31 11.6 0.2 2.2 1 1 0 1 1 1 0 AAA domain AF2331-like PF14556.6 EPA05448.1 - 0.041 14.5 0.1 0.11 13.1 0.1 1.7 1 0 0 1 1 1 0 AF2331-like ResIII PF04851.15 EPA05448.1 - 0.042 13.9 2.6 0.072 13.1 2.6 1.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit NTPase_1 PF03266.15 EPA05448.1 - 0.05 13.5 1.0 0.48 10.3 1.0 2.1 1 1 0 1 1 1 0 NTPase Roc PF08477.13 EPA05448.1 - 0.05 13.8 2.0 0.42 10.8 0.2 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 EPA05448.1 - 0.057 12.8 0.2 0.12 11.7 0.1 1.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family NB-ARC PF00931.22 EPA05448.1 - 0.08 12.1 0.5 0.13 11.4 0.5 1.6 1 1 0 1 1 1 0 NB-ARC domain AAA PF00004.29 EPA05448.1 - 0.15 12.5 1.3 0.3 11.5 1.3 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) EMG1 PF03587.14 EPA05448.1 - 0.32 10.6 3.8 2.1 7.9 3.8 2.0 1 1 0 1 1 1 0 EMG1/NEP1 methyltransferase Response_reg PF00072.24 EPA05449.1 - 1e-24 86.8 0.2 1.2e-24 86.6 0.2 1.1 1 0 0 1 1 1 1 Response regulator receiver domain MCPsignal PF00015.21 EPA05451.1 - 3.2e-39 134.5 43.3 1e-37 129.6 24.0 3.6 1 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain PAS PF00989.25 EPA05451.1 - 1.3e-09 38.0 0.3 8.5e-09 35.4 0.0 2.3 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EPA05451.1 - 6.6e-09 36.0 0.4 2.9e-08 33.9 0.1 2.3 2 0 0 2 2 2 1 PAS domain PAS_3 PF08447.12 EPA05451.1 - 3.4e-08 33.6 0.1 1.1e-07 32.1 0.1 1.8 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EPA05451.1 - 0.0005 20.3 0.0 0.002 18.3 0.0 2.0 2 0 0 2 2 2 1 PAS fold Spc7 PF08317.11 EPA05451.1 - 0.033 13.1 25.3 0.031 13.2 3.9 3.2 1 1 1 3 3 3 0 Spc7 kinetochore protein Stanniocalcin PF03298.13 EPA05451.1 - 0.048 13.0 1.0 1.1 8.5 0.1 2.4 2 0 0 2 2 2 0 Stanniocalcin family HisKA PF00512.25 EPA05451.1 - 0.076 13.1 0.9 22 5.2 0.0 3.2 2 1 0 2 2 2 0 His Kinase A (phospho-acceptor) domain DUF745 PF05335.13 EPA05451.1 - 0.25 11.0 26.7 1 9.1 12.3 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF745) COG2 PF06148.11 EPA05451.1 - 0.26 11.4 20.5 2.1 8.4 1.3 4.6 2 2 3 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 Fib_alpha PF08702.10 EPA05451.1 - 0.67 10.1 28.0 0.25 11.5 6.6 3.6 2 2 2 4 4 4 0 Fibrinogen alpha/beta chain family APG17 PF04108.12 EPA05451.1 - 0.79 8.8 21.3 12 4.8 21.0 2.6 1 1 0 1 1 1 0 Autophagy protein Apg17 DUF812 PF05667.11 EPA05451.1 - 2.5 6.9 29.5 9.5 5.0 11.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Sec34 PF04136.15 EPA05451.1 - 3.1 7.7 20.9 0.061 13.2 3.9 3.7 2 2 2 4 4 4 0 Sec34-like family COG5 PF10392.9 EPA05451.1 - 4.3 7.5 15.7 0.17 12.1 4.1 3.1 2 2 0 2 2 2 0 Golgi transport complex subunit 5 DUF948 PF06103.11 EPA05451.1 - 4.8 7.5 32.6 1 9.7 3.1 4.6 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) T7SS_ESX_EspC PF10824.8 EPA05451.1 - 8.6 6.9 14.1 4.3 7.9 0.0 4.2 1 1 5 6 6 6 0 Excreted virulence factor EspC, type VII ESX diderm CHDCT2 PF08074.11 EPA05451.1 - 8.9 6.5 15.2 3.6 7.7 4.7 2.9 2 1 1 3 3 3 0 CHDCT2 (NUC038) domain Laminin_II PF06009.12 EPA05451.1 - 9.4 6.3 31.8 0.45 10.5 2.8 4.1 2 2 1 3 3 3 0 Laminin Domain II BLOC1_2 PF10046.9 EPA05451.1 - 9.9 6.5 27.3 6 7.2 1.5 4.8 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HATPase_c PF02518.26 EPA05452.1 - 3e-16 59.9 1.0 6.3e-16 58.9 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EPA05452.1 - 2.1e-07 30.8 0.0 6.8e-07 29.2 0.0 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EPA05452.1 - 0.0069 16.3 0.1 0.0069 16.3 0.1 2.9 3 0 0 3 3 3 1 GHKL domain LapA_dom PF06305.11 EPA05452.1 - 0.037 13.9 0.2 0.037 13.9 0.2 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain AFP_2 PF18815.1 EPA05452.1 - 4.9 7.5 13.0 0.73 10.1 1.1 3.9 3 0 0 3 3 3 0 Bacterial antifreeze protein repeat CheC PF04509.12 EPA05453.1 - 4.3e-12 45.7 0.0 8.8e-12 44.7 0.0 1.6 1 0 0 1 1 1 1 CheC-like family CheX PF13690.6 EPA05453.1 - 1.7e-07 31.3 0.0 3.1e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Chemotaxis phosphatase CheX HATPase_c PF02518.26 EPA05455.1 - 4.2e-17 62.6 2.0 5.5e-17 62.3 0.3 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EPA05455.1 - 4.9e-10 39.3 2.3 2.2e-08 34.0 0.0 3.2 2 1 0 3 3 3 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EPA05455.1 - 1.2e-07 31.5 0.1 4e-07 29.9 0.0 2.0 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 EPA05455.1 - 0.01 15.6 0.0 0.051 13.4 0.0 2.2 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EPA05455.1 - 0.012 15.5 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain PI3K_P85_iSH2 PF16454.5 EPA05455.1 - 0.61 9.7 15.9 0.11 12.1 12.2 1.6 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ER PF01133.17 EPA05456.1 - 0.038 14.0 0.3 0.042 13.9 0.3 1.2 1 0 0 1 1 1 0 Enhancer of rudimentary Arch_flagellin PF01917.16 EPA05457.1 - 2.1e-10 41.0 6.9 2.7e-10 40.7 6.9 1.0 1 0 0 1 1 1 1 Archaebacterial flagellin Big_5 PF13205.6 EPA05457.1 - 0.038 14.7 1.1 0.053 14.2 0.4 1.6 1 1 1 2 2 2 0 Bacterial Ig-like domain DUF973 PF06157.11 EPA05457.1 - 0.67 9.0 10.7 7 5.6 10.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF973) T2SSE PF00437.20 EPA05458.1 - 1.3e-43 149.0 0.0 1.8e-43 148.6 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein Response_reg PF00072.24 EPA05459.1 - 3.4e-28 98.1 0.7 3.8e-28 97.9 0.7 1.0 1 0 0 1 1 1 1 Response regulator receiver domain Response_reg PF00072.24 EPA05460.1 - 4.2e-14 52.6 0.3 5.2e-14 52.4 0.3 1.1 1 0 0 1 1 1 1 Response regulator receiver domain Toprim_2 PF13155.6 EPA05460.1 - 0.054 13.9 0.3 0.32 11.5 0.1 1.9 1 1 1 2 2 2 0 Toprim-like ETRAMP PF09716.10 EPA05462.1 - 1.2 9.3 5.1 18 5.5 0.0 2.9 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) zf-C2H2 PF00096.26 EPA05463.1 - 0.012 16.1 0.8 0.019 15.4 0.8 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EPA05463.1 - 0.014 16.2 0.7 0.02 15.7 0.7 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EPA05463.1 - 0.026 14.8 0.7 0.026 14.8 0.7 1.0 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) HNH_5 PF14279.6 EPA05463.1 - 0.038 13.9 0.1 0.043 13.7 0.1 1.1 1 0 0 1 1 1 0 HNH endonuclease zf-C2H2_3 PF13878.6 EPA05463.1 - 0.041 13.7 0.4 0.047 13.5 0.1 1.4 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO NHL PF01436.21 EPA05464.1 - 2e-11 43.3 8.0 0.061 13.4 0.1 7.3 7 1 1 8 8 8 3 NHL repeat Lactonase PF10282.9 EPA05464.1 - 1.7e-08 34.1 1.5 0.043 13.1 0.0 4.6 1 1 4 5 5 5 3 Lactonase, 7-bladed beta-propeller Cytochrom_D1 PF02239.16 EPA05464.1 - 0.00014 20.6 3.8 0.1 11.1 0.3 2.6 1 1 0 2 2 2 2 Cytochrome D1 heme domain Arylesterase PF01731.20 EPA05464.1 - 0.00033 20.8 14.3 4.3 7.6 0.1 5.9 4 1 2 6 6 6 2 Arylesterase Glu_cyclase_2 PF05096.12 EPA05464.1 - 0.0042 16.6 4.7 0.19 11.1 1.6 2.6 1 1 1 3 3 3 2 Glutamine cyclotransferase ANAPC4_WD40 PF12894.7 EPA05464.1 - 0.028 14.7 1.3 6.1 7.2 0.0 3.3 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain GDPD PF03009.17 EPA05464.1 - 0.032 14.0 0.0 0.098 12.4 0.0 1.7 1 1 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family SdiA-regulated PF06977.11 EPA05464.1 - 0.04 13.1 0.4 13 4.9 0.0 3.2 2 1 0 2 2 2 0 SdiA-regulated FHA PF00498.26 EPA05464.1 - 2.1 8.7 5.0 18 5.8 1.1 3.6 2 1 1 3 3 3 0 FHA domain CheW PF01584.19 EPA05465.1 - 2.8e-33 114.5 0.2 3.4e-33 114.2 0.2 1.1 1 0 0 1 1 1 1 CheW-like domain Peptidase_C31 PF05410.13 EPA05466.1 - 0.15 12.1 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Porcine arterivirus-type cysteine proteinase alpha CheD PF03975.13 EPA05468.1 - 3e-15 56.2 0.0 4.3e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 CheD chemotactic sensory transduction Cu-oxidase_4 PF02578.15 EPA05468.1 - 0.2 11.2 0.0 0.3 10.7 0.0 1.2 1 0 0 1 1 1 0 Multi-copper polyphenol oxidoreductase laccase Response_reg PF00072.24 EPA05469.1 - 4.4e-24 84.8 0.1 5.5e-24 84.5 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain THF_DHG_CYH PF00763.23 EPA05469.1 - 0.052 13.8 0.1 0.091 13.0 0.1 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain EcoEI_R_C PF08463.10 EPA05469.1 - 0.067 13.3 0.2 0.12 12.5 0.2 1.3 1 0 0 1 1 1 0 EcoEI R protein C-terminal CheB_methylest PF01339.17 EPA05470.1 - 1e-58 197.8 0.0 3.8e-58 196.0 0.0 1.8 2 0 0 2 2 2 1 CheB methylesterase Response_reg PF00072.24 EPA05470.1 - 8e-21 74.3 1.2 1.7e-20 73.2 1.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain DUF3362 PF11842.8 EPA05471.1 - 0.0055 17.0 0.0 0.0062 16.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3362) RNA_pol_Rpc82 PF05645.13 EPA05471.1 - 0.029 14.1 3.6 0.036 13.8 3.6 1.1 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 O-antigen_lig PF13425.6 EPA05471.1 - 0.036 12.9 1.4 0.036 12.9 1.4 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PRP1_N PF06424.12 EPA05471.1 - 0.042 14.3 3.5 0.06 13.7 3.5 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF1514 PF07438.11 EPA05471.1 - 0.11 12.4 2.0 0.11 12.4 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1514) Nucleoside_tran PF01733.18 EPA05471.1 - 0.19 11.1 0.2 0.21 10.9 0.2 1.1 1 0 0 1 1 1 0 Nucleoside transporter Secretin_N_2 PF07655.13 EPA05471.1 - 0.22 12.1 4.1 0.3 11.6 4.1 1.1 1 0 0 1 1 1 0 Secretin N-terminal domain CheW PF01584.19 EPA05472.1 - 1.3e-19 70.2 0.1 2.2e-19 69.4 0.1 1.4 1 0 0 1 1 1 1 CheW-like domain Hpt PF01627.23 EPA05472.1 - 1.4e-14 54.1 0.0 2.6e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 Hpt domain HATPase_c PF02518.26 EPA05472.1 - 1.4e-14 54.6 6.7 2.8e-14 53.6 3.6 2.5 1 1 1 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase H-kinase_dim PF02895.14 EPA05472.1 - 4.8e-09 36.5 0.5 1.7e-08 34.7 0.5 2.0 1 0 0 1 1 1 1 Signal transducing histidine kinase, homodimeric domain HATPase_c_3 PF13589.6 EPA05472.1 - 0.00066 19.5 1.3 0.0011 18.8 0.5 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EPA05472.1 - 0.011 15.7 0.0 0.023 14.7 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain CheR PF01739.18 EPA05473.1 - 2.3e-51 174.1 0.2 3e-51 173.7 0.2 1.1 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain CheR_N PF03705.15 EPA05473.1 - 1.1e-08 34.6 0.1 3.2e-08 33.2 0.1 1.7 1 0 0 1 1 1 1 CheR methyltransferase, all-alpha domain Methyltransf_12 PF08242.12 EPA05473.1 - 5.7e-07 30.2 0.1 3.3e-05 24.6 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA05473.1 - 8.1e-07 29.0 1.3 1.8e-05 24.6 0.5 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA05473.1 - 7.4e-06 26.6 0.0 0.0016 19.1 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA05473.1 - 1.3e-05 25.8 0.0 0.00012 22.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EPA05473.1 - 0.00041 20.2 0.0 0.00059 19.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FUR PF01475.19 EPA05474.1 - 0.071 13.3 0.7 0.18 11.9 0.0 2.0 2 1 0 2 2 2 0 Ferric uptake regulator family Pyr_redox_2 PF07992.14 EPA05475.1 - 7e-44 150.2 0.0 8.6e-44 149.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EPA05475.1 - 1.3e-09 38.4 0.4 3.3e-07 30.8 0.3 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thioredoxin_8 PF13905.6 EPA05475.1 - 0.053 13.9 0.2 0.88 9.9 0.0 2.7 2 0 0 2 2 2 0 Thioredoxin-like DUF835 PF05763.12 EPA05475.1 - 0.072 12.8 1.0 0.22 11.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF835) Sacchrp_dh_NADP PF03435.18 EPA05475.1 - 0.19 12.0 0.9 0.32 11.3 0.0 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain GATase PF00117.28 EPA05476.1 - 4.7e-23 81.9 0.0 5.2e-23 81.8 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EPA05476.1 - 0.00049 19.9 0.1 0.00081 19.2 0.1 1.7 1 1 0 1 1 1 1 Peptidase C26 Sod_Fe_C PF02777.18 EPA05478.1 - 1.2e-38 131.4 0.1 2e-38 130.6 0.1 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EPA05478.1 - 1.9e-29 102.0 1.4 3.3e-29 101.2 1.4 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Fer4_13 PF13370.6 EPA05478.1 - 0.047 14.2 0.1 0.098 13.2 0.1 1.5 1 0 0 1 1 1 0 4Fe-4S single cluster domain of Ferredoxin I SRP54 PF00448.22 EPA05479.1 - 3.2e-70 235.8 0.6 4.5e-70 235.3 0.6 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 EPA05479.1 - 1.4e-09 38.1 4.4 1.4e-09 38.1 4.4 2.0 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain AAA_30 PF13604.6 EPA05479.1 - 1.8e-07 31.0 0.1 4.1e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EPA05479.1 - 7.5e-06 25.4 0.1 1.2e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.6 EPA05479.1 - 5.5e-05 23.4 0.1 0.00014 22.1 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EPA05479.1 - 0.00026 21.4 0.0 0.00061 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 EPA05479.1 - 0.00052 19.7 0.9 0.0047 16.5 0.9 2.1 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 EPA05479.1 - 0.00062 20.2 0.1 0.002 18.5 0.1 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EPA05479.1 - 0.0013 18.9 0.0 0.002 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EPA05479.1 - 0.0021 17.3 0.1 0.0035 16.6 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EPA05479.1 - 0.0031 17.9 0.2 0.0051 17.2 0.2 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EPA05479.1 - 0.0042 17.5 0.0 0.0076 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 EPA05479.1 - 0.0057 16.7 0.1 0.028 14.5 0.0 2.1 1 1 1 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain APS_kinase PF01583.20 EPA05479.1 - 0.0059 16.5 0.1 0.025 14.5 0.0 2.0 2 0 0 2 2 2 1 Adenylylsulphate kinase Thymidylate_kin PF02223.17 EPA05479.1 - 0.007 16.1 0.0 0.023 14.3 0.0 1.9 2 0 0 2 2 2 1 Thymidylate kinase PIF1 PF05970.14 EPA05479.1 - 0.0089 15.2 0.1 0.014 14.6 0.1 1.2 1 0 0 1 1 1 1 PIF1-like helicase TPP_enzyme_M PF00205.22 EPA05479.1 - 0.0093 15.7 0.2 0.15 11.8 0.1 2.6 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain TK PF00265.18 EPA05479.1 - 0.0096 15.8 0.1 0.019 14.9 0.1 1.4 1 0 0 1 1 1 1 Thymidine kinase NTPase_1 PF03266.15 EPA05479.1 - 0.011 15.7 0.5 0.91 9.4 0.1 2.4 1 1 0 2 2 2 0 NTPase AAA_14 PF13173.6 EPA05479.1 - 0.014 15.5 0.6 0.036 14.1 0.0 2.0 2 1 0 2 2 2 0 AAA domain KdpD PF02702.17 EPA05479.1 - 0.019 14.5 0.1 0.036 13.5 0.1 1.4 1 0 0 1 1 1 0 Osmosensitive K+ channel His kinase sensor domain ABC_tran PF00005.27 EPA05479.1 - 0.019 15.5 0.1 0.043 14.3 0.1 1.7 1 1 0 1 1 1 0 ABC transporter DAP3 PF10236.9 EPA05479.1 - 0.022 14.0 0.1 0.038 13.2 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_7 PF12775.7 EPA05479.1 - 0.032 13.7 0.0 0.062 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EPA05479.1 - 0.035 13.8 0.0 0.073 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 EPA05479.1 - 0.036 13.0 0.1 0.13 11.2 0.1 1.9 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB KTI12 PF08433.10 EPA05479.1 - 0.038 13.4 0.2 0.083 12.3 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 CLP1_P PF16575.5 EPA05479.1 - 0.045 13.5 0.1 0.11 12.3 0.0 1.6 1 1 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SPOUT_MTase PF02590.17 EPA05479.1 - 0.054 13.5 0.1 0.26 11.2 0.0 1.9 1 1 1 2 2 2 0 Predicted SPOUT methyltransferase AAA_5 PF07728.14 EPA05479.1 - 0.055 13.5 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) B12-binding PF02310.19 EPA05479.1 - 0.062 13.3 0.1 0.21 11.6 0.1 1.9 1 1 0 1 1 1 0 B12 binding domain AAA_28 PF13521.6 EPA05479.1 - 0.066 13.4 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 EPA05479.1 - 0.089 12.7 0.3 0.32 10.9 0.1 1.9 1 1 1 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ResIII PF04851.15 EPA05479.1 - 0.095 12.7 1.5 0.31 11.0 1.3 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit MMR_HSR1 PF01926.23 EPA05479.1 - 0.1 12.7 2.3 0.39 10.8 0.3 2.6 1 1 2 3 3 3 0 50S ribosome-binding GTPase PPK2 PF03976.14 EPA05479.1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) Lip_prot_lig_C PF10437.9 EPA05479.1 - 0.46 10.5 3.2 1.4 9.0 0.1 3.1 2 1 1 3 3 3 0 Bacterial lipoate protein ligase C-terminus Prefoldin PF02996.17 EPA05480.1 - 6.8e-16 58.3 7.7 2.6e-15 56.4 7.7 1.8 1 1 0 1 1 1 1 Prefoldin subunit LMP PF04778.12 EPA05480.1 - 0.00079 19.4 0.6 0.0012 18.8 0.1 1.5 2 0 0 2 2 2 1 LMP repeated region Ribosomal_L5 PF00281.19 EPA05480.1 - 0.038 14.3 0.8 0.15 12.4 0.1 2.4 3 0 0 3 3 3 0 Ribosomal protein L5 DUF3848 PF12959.7 EPA05480.1 - 0.21 11.7 2.6 0.27 11.3 0.2 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3848) TMF_TATA_bd PF12325.8 EPA05480.1 - 0.21 11.8 8.8 0.64 10.3 0.9 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Prefoldin_2 PF01920.20 EPA05480.1 - 0.24 11.4 10.5 0.058 13.4 1.3 2.3 2 1 0 2 2 2 0 Prefoldin subunit OmpH PF03938.14 EPA05480.1 - 0.32 11.3 13.6 0.55 10.6 2.6 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Paralemmin PF03285.15 EPA05480.1 - 0.61 9.6 5.7 3.4 7.2 1.1 2.0 2 0 0 2 2 2 0 Paralemmin Tho2 PF11262.8 EPA05480.1 - 1.4 8.0 4.2 0.28 10.3 0.7 1.5 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 ABC_tran_CTD PF16326.5 EPA05480.1 - 1.4 9.2 10.8 0.12 12.7 2.8 2.3 2 1 0 2 2 2 0 ABC transporter C-terminal domain TSNAXIP1_N PF15739.5 EPA05480.1 - 1.7 9.1 10.2 0.11 12.9 2.2 2.1 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus CLZ PF16526.5 EPA05480.1 - 2.9 8.3 7.8 6.5 7.2 1.6 2.3 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF3947 PF13135.6 EPA05480.1 - 3.7 7.8 6.9 5.8 7.2 1.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3947) Copper-bind PF00127.20 EPA05482.1 - 9.8e-15 54.8 0.4 2.2e-07 31.2 0.0 2.6 2 1 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cu-oxidase_3 PF07732.15 EPA05482.1 - 6.9e-11 42.2 0.8 3e-05 24.0 0.1 3.1 2 2 0 2 2 2 2 Multicopper oxidase Cupredoxin_1 PF13473.6 EPA05482.1 - 3.3e-09 36.8 0.0 0.00037 20.6 0.0 2.6 2 0 0 2 2 2 2 Cupredoxin-like domain SoxE PF06525.11 EPA05482.1 - 2.2e-08 33.7 0.5 0.0079 15.7 0.0 2.7 2 1 0 2 2 2 2 Sulfocyanin (SoxE) domain Cu_bind_like PF02298.17 EPA05482.1 - 1.3e-06 28.4 0.0 0.037 14.0 0.0 2.9 2 1 0 2 2 2 2 Plastocyanin-like domain Cu-oxidase_2 PF07731.14 EPA05482.1 - 2.5e-06 27.3 0.0 0.0043 16.8 0.0 2.7 2 2 0 2 2 2 2 Multicopper oxidase DUF2475 PF10629.9 EPA05482.1 - 0.0057 16.8 0.0 5.5 7.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2475) CHU_C PF13585.6 EPA05482.1 - 0.0064 16.5 0.1 1.8 8.7 0.0 2.5 2 0 0 2 2 2 1 C-terminal domain of CHU protein family PGBA_N PF15436.6 EPA05482.1 - 0.012 15.3 0.0 1.8 8.1 0.0 2.1 2 0 0 2 2 2 0 Plasminogen-binding protein pgbA N-terminal PPC PF04151.15 EPA05482.1 - 0.5 11.5 4.5 0.56 11.4 0.3 2.6 2 1 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain HisKA PF00512.25 EPA05484.1 - 0.028 14.5 0.1 0.031 14.3 0.1 1.2 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain Wbp11 PF09429.10 EPA05484.1 - 0.089 13.2 0.2 0.11 12.9 0.2 1.2 1 0 0 1 1 1 0 WW domain binding protein 11 AA_kinase PF00696.28 EPA05486.1 - 2.2e-25 89.7 0.4 4e-25 88.8 0.4 1.5 1 0 0 1 1 1 1 Amino acid kinase family Putative_PNPOx PF01243.20 EPA05487.1 - 9e-16 57.8 0.0 2.1e-15 56.7 0.0 1.6 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 EPA05487.1 - 8.9e-10 38.7 0.0 1.3e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase YmdB PF13277.6 EPA05487.1 - 0.00052 19.4 0.0 0.00063 19.2 0.0 1.2 1 0 0 1 1 1 1 YmdB-like protein Pyrid_ox_like PF16242.5 EPA05487.1 - 0.0091 15.6 0.1 0.0093 15.6 0.1 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like DUF2228 PF10228.9 EPA05487.1 - 0.019 14.7 0.4 0.02 14.6 0.4 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) Aminotran_4 PF01063.19 EPA05488.1 - 1.1e-48 166.0 0.0 1.4e-48 165.7 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV BRCT PF00533.26 EPA05488.1 - 0.088 13.2 0.1 0.43 11.0 0.0 2.1 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain COX15-CtaA PF02628.15 EPA05489.1 - 2.2e-18 66.4 15.2 3.2e-14 52.8 8.1 2.0 1 1 1 2 2 2 2 Cytochrome oxidase assembly protein SLATT_fungal PF18142.1 EPA05489.1 - 0.41 10.6 2.6 0.36 10.8 0.6 1.9 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain DUF2614 PF11023.8 EPA05489.1 - 1.1 9.4 6.6 1.7 8.8 2.2 2.1 2 0 0 2 2 2 0 Zinc-ribbon containing domain COX1 PF00115.20 EPA05490.1 - 3.8e-132 441.2 61.7 4.8e-132 440.9 61.7 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I WRC PF08879.10 EPA05491.1 - 0.093 12.4 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 WRC adh_short_C2 PF13561.6 EPA05492.1 - 9.8e-19 67.8 0.0 1.2e-17 64.3 0.0 1.9 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EPA05492.1 - 1.4e-17 63.9 0.1 1.1e-12 47.8 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase RmlD_sub_bind PF04321.17 EPA05492.1 - 0.015 14.4 0.0 0.03 13.4 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain UPF0193 PF05250.11 EPA05492.1 - 0.039 13.8 0.0 0.056 13.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0193) Polyketide_cyc2 PF10604.9 EPA05493.1 - 6.9e-08 32.9 0.0 8.8e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AHSA1 PF08327.11 EPA05493.1 - 1.7e-07 31.5 0.0 2.7e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc PF03364.20 EPA05493.1 - 1.1e-06 28.9 0.0 1.6e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport CbiA PF01656.23 EPA05495.1 - 2.3e-16 60.0 0.0 3.8e-16 59.3 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.6 EPA05495.1 - 2e-15 57.2 0.1 1.6e-14 54.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain MobB PF03205.14 EPA05495.1 - 7.1e-05 22.7 0.0 0.0015 18.4 0.0 2.2 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.22 EPA05495.1 - 0.00037 20.2 0.4 0.39 10.3 0.1 2.2 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 EPA05495.1 - 0.0067 16.3 0.0 0.06 13.3 0.0 2.0 2 0 0 2 2 2 1 NTPase AAA_23 PF13476.6 EPA05495.1 - 0.014 15.9 0.1 0.02 15.4 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EPA05495.1 - 0.015 15.7 0.0 0.016 15.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain CBP_BcsQ PF06564.12 EPA05495.1 - 0.019 14.5 0.0 0.16 11.5 0.0 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ AAA_31 PF13614.6 EPA05495.1 - 0.034 14.1 1.3 0.14 12.0 0.7 2.1 1 1 0 1 1 1 0 AAA domain DUF1533 PF07550.11 EPA05495.1 - 0.042 13.7 0.5 0.042 13.7 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1533) SelA PF03841.13 EPA05495.1 - 0.049 12.6 0.1 0.061 12.3 0.1 1.1 1 0 0 1 1 1 0 L-seryl-tRNA selenium transferase APS_kinase PF01583.20 EPA05495.1 - 0.065 13.1 0.0 0.089 12.7 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase cobW PF02492.19 EPA05495.1 - 0.07 12.7 0.1 0.81 9.2 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PRK PF00485.18 EPA05495.1 - 0.095 12.4 0.2 0.12 12.1 0.2 1.5 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family VirC1 PF07015.11 EPA05495.1 - 0.14 11.4 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 VirC1 protein AAA_30 PF13604.6 EPA05495.1 - 0.17 11.6 0.0 0.19 11.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain Glyco_tran_28_C PF04101.16 EPA05498.1 - 1.8e-11 44.3 0.1 9.2e-11 42.0 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.6 EPA05498.1 - 3.3e-07 29.9 0.0 0.00038 19.8 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 1 Glyco_trans_1_4 PF13692.6 EPA05498.1 - 0.012 16.0 0.0 0.08 13.4 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferases group 1 CCDC117 PF15810.5 EPA05498.1 - 0.051 13.9 0.4 0.08 13.2 0.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 117 PKD PF00801.20 EPA05499.1 - 0.059 13.2 0.0 4.5 7.2 0.0 2.4 1 1 1 2 2 2 0 PKD domain IF-2B PF01008.17 EPA05501.1 - 2.2e-86 289.6 1.3 3e-86 289.1 0.8 1.4 1 1 1 2 2 2 1 Initiation factor 2 subunit family PAC4 PF16093.5 EPA05502.1 - 4.4e-08 33.2 0.1 6.1e-08 32.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Chlam_vir PF05475.11 EPA05502.1 - 0.029 14.1 0.1 0.039 13.7 0.1 1.3 1 1 0 1 1 1 0 Pgp3 C-terminal domain UbiA PF01040.18 EPA05503.1 - 6.9e-41 140.2 21.5 9e-41 139.8 21.5 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Response_reg PF00072.24 EPA05504.1 - 1.6e-24 86.2 1.1 1.9e-24 86.0 1.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain HydF_dimer PF18128.1 EPA05504.1 - 0.0061 16.6 0.1 0.21 11.7 0.0 2.3 1 1 0 2 2 2 1 Hydrogen maturase F dimerization domain Ribosomal_S27e PF01667.17 EPA05505.1 - 6.5e-18 64.2 1.2 7.8e-18 63.9 1.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S27 zf-ribbon_3 PF13248.6 EPA05505.1 - 0.00033 20.0 2.3 0.24 10.9 0.2 2.2 2 0 0 2 2 2 2 zinc-ribbon domain Zn_Tnp_IS91 PF14319.6 EPA05505.1 - 0.0014 18.6 0.5 0.0016 18.4 0.5 1.1 1 0 0 1 1 1 1 Transposase zinc-binding domain TF_Zn_Ribbon PF08271.12 EPA05505.1 - 0.0047 16.4 0.9 0.0058 16.1 0.9 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding zinc_ribbon_6 PF14599.6 EPA05505.1 - 0.0076 16.2 2.7 0.04 13.9 2.9 1.9 1 1 0 1 1 1 1 Zinc-ribbon C1_1 PF00130.22 EPA05505.1 - 0.0099 15.7 0.6 0.014 15.3 0.6 1.2 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) YhfH PF14149.6 EPA05505.1 - 0.015 15.2 0.9 1.3 9.1 0.0 2.2 2 0 0 2 2 2 0 YhfH-like protein zf-dskA_traR PF01258.17 EPA05505.1 - 0.023 14.7 0.3 6.6 6.8 0.0 2.2 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger zf-BED PF02892.15 EPA05505.1 - 0.03 14.3 4.9 0.29 11.2 0.5 2.3 1 1 1 2 2 2 0 BED zinc finger Zn-ribbon_8 PF09723.10 EPA05505.1 - 0.035 14.2 1.1 0.063 13.4 1.1 1.5 1 1 0 1 1 1 0 Zinc ribbon domain HypA PF01155.19 EPA05505.1 - 0.038 14.0 0.5 0.044 13.8 0.5 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2318 PF10080.9 EPA05505.1 - 0.044 13.9 2.4 0.056 13.6 2.4 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2318) ZZ PF00569.17 EPA05505.1 - 0.13 12.1 5.7 0.87 9.4 0.4 2.2 1 1 1 2 2 2 0 Zinc finger, ZZ type Rubredoxin_2 PF18073.1 EPA05505.1 - 0.22 11.2 3.1 6.3 6.6 0.2 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain Sgf11 PF08209.11 EPA05505.1 - 0.4 10.3 4.2 1.5 8.5 0.2 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zinc_ribbon_12 PF11331.8 EPA05505.1 - 0.6 10.0 3.6 4.1 7.3 0.3 2.1 1 1 0 2 2 2 0 Probable zinc-ribbon domain TFIIS_C PF01096.18 EPA05505.1 - 0.66 9.9 3.5 38 4.2 3.5 2.1 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS) zf_C2H2_13 PF18508.1 EPA05505.1 - 1.7 8.3 6.3 1.6 8.4 0.6 2.4 1 1 1 2 2 2 0 Zinc finger domain zf-C2H2_3 PF13878.6 EPA05505.1 - 2.9 7.8 5.4 2.4 8.1 0.8 2.2 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO AsnC_trans_reg PF01037.21 EPA05506.1 - 9.6e-13 47.9 0.1 1.7e-12 47.1 0.1 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain B-block_TFIIIC PF04182.12 EPA05506.1 - 0.014 15.5 0.1 0.029 14.5 0.1 1.6 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC MarR PF01047.22 EPA05506.1 - 0.031 14.2 0.1 0.068 13.1 0.1 1.5 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 EPA05506.1 - 0.06 12.9 0.3 0.17 11.5 0.1 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding SAM_LFY PF01698.16 EPA05506.1 - 0.12 12.3 0.8 3 7.9 0.2 2.2 1 1 1 2 2 2 0 Floricaula / Leafy protein SAM domain His_Phos_1 PF00300.22 EPA05507.1 - 1.5e-50 171.6 0.0 1.7e-50 171.4 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) CRM1_C PF08767.11 EPA05507.1 - 0.061 12.5 0.3 0.14 11.3 0.1 1.7 2 1 0 2 2 2 0 CRM1 C terminal CobS PF02654.15 EPA05508.1 - 2.3e-06 27.9 0.2 2.4e-06 27.9 0.2 1.0 1 0 0 1 1 1 1 Cobalamin-5-phosphate synthase F420_oxidored PF03807.17 EPA05509.1 - 7.7e-17 61.7 0.1 1.2e-16 61.1 0.1 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 EPA05509.1 - 0.002 18.6 0.0 0.0031 17.9 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EPA05509.1 - 0.007 16.6 0.0 0.0099 16.1 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 EPA05509.1 - 0.023 14.4 0.0 0.04 13.5 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DapB_N PF01113.20 EPA05509.1 - 0.026 14.6 0.1 0.045 13.9 0.1 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus PDH PF02153.17 EPA05509.1 - 0.029 13.4 0.0 0.04 12.9 0.0 1.3 1 0 0 1 1 1 0 Prephenate dehydrogenase NAD_Gly3P_dh_N PF01210.23 EPA05509.1 - 0.054 13.5 0.0 0.099 12.6 0.0 1.6 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus adh_short PF00106.25 EPA05509.1 - 0.077 12.4 0.1 0.13 11.7 0.1 1.2 1 0 0 1 1 1 0 short chain dehydrogenase Adenine_deam_C PF13382.6 EPA05510.1 - 1.8e-46 157.6 0.1 4.1e-46 156.4 0.0 1.6 2 0 0 2 2 2 1 Adenine deaminase C-terminal domain Amidohydro_1 PF01979.20 EPA05510.1 - 1.9e-16 60.3 0.0 2.3e-15 56.8 0.0 2.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EPA05510.1 - 4.9e-08 32.9 0.0 0.0012 18.4 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family DUF2099 PF09872.9 EPA05510.1 - 0.069 12.3 0.1 0.28 10.3 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2099) NMT PF01233.19 EPA05510.1 - 0.12 12.2 0.0 0.46 10.3 0.0 1.8 1 1 0 2 2 2 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NTP_transf_3 PF12804.7 EPA05512.1 - 3.9e-13 50.1 0.0 4.9e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 EPA05512.1 - 9.9e-08 32.0 0.0 1.3e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NTP_transferase PF00483.23 EPA05512.1 - 0.00075 19.1 0.0 0.00097 18.8 0.0 1.4 1 1 0 1 1 1 1 Nucleotidyl transferase NIF PF03031.18 EPA05512.1 - 0.017 14.9 1.3 0.4 10.4 0.3 2.3 2 1 0 2 2 2 0 NLI interacting factor-like phosphatase YfzA PF14118.6 EPA05514.1 - 0.016 15.6 0.8 0.021 15.2 0.8 1.3 1 1 0 1 1 1 0 YfzA-like protein L6_membrane PF05805.12 EPA05514.1 - 0.021 14.4 0.3 0.025 14.1 0.3 1.0 1 0 0 1 1 1 0 L6 membrane protein Gram_pos_anchor PF00746.21 EPA05514.1 - 0.023 14.6 1.7 0.76 9.8 0.1 2.1 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DUF202 PF02656.15 EPA05514.1 - 0.024 15.1 1.5 0.058 13.8 1.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF202) DUF334 PF03904.13 EPA05514.1 - 0.13 11.8 0.2 0.13 11.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF334) Ribosomal_L44 PF00935.19 EPA05515.1 - 5.1e-24 84.5 9.0 5.1e-24 84.5 9.0 1.4 1 1 1 2 2 2 1 Ribosomal protein L44 Ribosomal_L33 PF00471.20 EPA05515.1 - 0.0055 17.1 4.1 0.25 11.8 1.1 2.6 2 0 0 2 2 2 2 Ribosomal protein L33 CPDase PF07823.11 EPA05516.1 - 3.9e-09 36.5 2.6 2.1e-08 34.1 2.6 2.0 1 1 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 EPA05516.1 - 2e-07 31.0 0.0 2.8e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 EPA05516.1 - 0.01 16.0 0.1 4.3 7.6 0.0 2.2 2 0 0 2 2 2 0 LigT like Phosphoesterase HVSL PF09749.9 EPA05516.1 - 0.019 14.4 1.9 0.063 12.7 1.9 1.9 1 1 0 1 1 1 0 Uncharacterised conserved protein KaiA PF07688.12 EPA05516.1 - 1.2 9.3 7.9 5 7.3 4.6 2.8 1 1 1 2 2 2 0 KaiA C-terminal domain EMP24_GP25L PF01105.24 EPA05517.1 - 0.01 15.8 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Invasin_D3 PF09134.10 EPA05517.1 - 0.011 16.0 0.1 0.019 15.3 0.1 1.3 1 0 0 1 1 1 0 Invasin, domain 3 Big_3 PF07523.12 EPA05517.1 - 0.063 13.6 0.1 0.26 11.6 0.2 1.9 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) SdrD_B PF17210.3 EPA05517.1 - 0.1 12.8 0.7 0.19 11.9 0.6 1.4 1 1 0 1 1 1 0 SdrD B-like domain Spore_YhaL PF14147.6 EPA05517.1 - 0.23 11.2 0.1 0.23 11.2 0.1 2.0 2 0 0 2 2 2 0 Sporulation protein YhaL ROK PF00480.20 EPA05518.1 - 2.3e-70 237.4 0.2 2.6e-70 237.2 0.2 1.0 1 0 0 1 1 1 1 ROK family BcrAD_BadFG PF01869.20 EPA05518.1 - 0.0012 18.5 0.2 0.0055 16.2 0.1 2.1 2 1 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family Hydant_A_N PF05378.13 EPA05518.1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase N-terminal region FGGY_N PF00370.21 EPA05518.1 - 0.05 13.2 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain CobD_Cbib PF03186.13 EPA05519.1 - 8.9e-85 284.2 0.0 1.1e-84 283.9 0.0 1.2 1 0 0 1 1 1 1 CobD/Cbib protein AAA_9 PF12781.7 EPA05519.1 - 0.1 11.7 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 ATP-binding dynein motor region E1-E2_ATPase PF00122.20 EPA05519.1 - 1.3 8.5 6.0 0.18 11.3 1.2 1.9 2 0 0 2 2 2 0 E1-E2 ATPase Putative_PNPOx PF01243.20 EPA05520.1 - 1.3e-13 51.0 0.0 3.7e-13 49.5 0.0 1.6 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase GatB_Yqey PF02637.18 EPA05520.1 - 0.012 15.5 1.3 0.012 15.5 1.3 1.5 2 0 0 2 2 2 0 GatB domain UbiD PF01977.16 EPA05521.1 - 1e-92 311.1 0.1 1.2e-92 311.0 0.1 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase PGP_phosphatase PF09419.10 EPA05521.1 - 0.029 14.0 0.6 0.59 9.7 0.1 2.3 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase Cpn60_TCP1 PF00118.24 EPA05522.1 - 1.2e-177 591.5 19.3 1.4e-177 591.3 19.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Semialdhyde_dhC PF02774.18 EPA05523.1 - 5.5e-36 124.4 0.0 8.2e-36 123.8 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EPA05523.1 - 1.1e-28 100.1 0.0 2e-28 99.2 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Paramyxo_PNT PF14320.6 EPA05523.1 - 0.011 14.9 0.1 0.017 14.3 0.1 1.3 1 0 0 1 1 1 0 Phosphoprotein P region PNT disordered Gp_dh_C PF02800.20 EPA05523.1 - 0.047 13.3 0.6 0.88 9.2 0.2 2.5 2 1 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain PilN PF05137.13 EPA05523.1 - 0.18 12.0 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 Fimbrial assembly protein (PilN) HATPase_c PF02518.26 EPA05524.1 - 7.6e-22 77.9 0.1 1.4e-21 77.1 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EPA05524.1 - 8.5e-12 44.9 0.5 1.7e-11 44.0 0.1 1.7 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EPA05524.1 - 1.5e-05 24.8 0.0 3.7e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 EPA05524.1 - 0.0033 17.3 0.1 0.0092 15.8 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MAPKK1_Int PF08923.10 EPA05524.1 - 0.022 14.6 0.0 0.052 13.4 0.0 1.6 1 0 0 1 1 1 0 Mitogen-activated protein kinase kinase 1 interacting HATPase_c_2 PF13581.6 EPA05524.1 - 0.041 13.9 0.0 0.069 13.1 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain CobD_Cbib PF03186.13 EPA05524.1 - 0.1 11.8 0.0 0.22 10.7 0.0 1.5 1 0 0 1 1 1 0 CobD/Cbib protein ASC PF00858.24 EPA05524.1 - 8.7 5.2 8.5 6.8 5.5 1.1 2.8 3 0 0 3 3 3 0 Amiloride-sensitive sodium channel COX2 PF00116.20 EPA05525.1 - 3e-14 52.9 1.2 5.3e-10 39.2 0.0 2.1 1 1 1 2 2 2 2 Cytochrome C oxidase subunit II, periplasmic domain Cupredoxin_1 PF13473.6 EPA05525.1 - 6e-05 23.1 0.0 7.4e-05 22.8 0.0 1.3 1 1 0 1 1 1 1 Cupredoxin-like domain FeS_assembly_P PF01883.19 EPA05526.1 - 1.3e-17 63.7 0.1 2.4e-17 62.8 0.1 1.5 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein PqqD PF05402.12 EPA05526.1 - 1.5e-10 41.2 0.1 2.6e-10 40.5 0.1 1.3 1 0 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) HemN_C PF06969.16 EPA05526.1 - 0.013 15.5 0.5 0.025 14.6 0.5 1.4 1 0 0 1 1 1 0 HemN C-terminal domain DUF4777 PF16007.5 EPA05526.1 - 0.096 13.0 0.2 0.21 11.9 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4777) HTH_46 PF15977.5 EPA05526.1 - 0.17 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA binding Aminotran_1_2 PF00155.21 EPA05527.1 - 2e-51 175.3 0.0 2.4e-51 175.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EPA05527.1 - 0.0066 15.5 0.0 0.017 14.1 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EPA05527.1 - 0.047 12.2 0.0 0.073 11.6 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EPA05528.1 - 2.1e-56 191.7 0.0 2.4e-56 191.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EPA05528.1 - 3.2e-07 30.0 0.0 5.1e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EPA05528.1 - 6.5e-06 25.3 0.0 1.3e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EPA05528.1 - 0.00031 19.4 0.0 0.00041 19.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EPA05528.1 - 0.12 11.6 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase 4HBT PF03061.22 EPA05529.1 - 1.6e-14 54.0 0.1 2.5e-14 53.4 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily MaoC_dehydratas PF01575.19 EPA05529.1 - 0.0002 20.9 0.2 0.00032 20.2 0.2 1.3 1 0 0 1 1 1 1 MaoC like domain OspE PF02471.17 EPA05529.1 - 0.025 14.8 0.1 0.039 14.2 0.1 1.3 1 0 0 1 1 1 0 Borrelia outer surface protein E CobS PF02654.15 EPA05530.1 - 3.7e-33 115.4 8.1 4.3e-33 115.2 8.1 1.0 1 0 0 1 1 1 1 Cobalamin-5-phosphate synthase RseC_MucC PF04246.12 EPA05530.1 - 0.021 14.8 1.5 0.021 14.8 1.5 2.1 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC TMEM208_SND2 PF05620.11 EPA05530.1 - 0.51 10.1 3.5 0.22 11.3 0.5 1.7 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Spore_III_AB PF09548.10 EPA05531.1 - 0.00028 21.1 6.5 0.00041 20.5 6.5 1.4 1 1 0 1 1 1 1 Stage III sporulation protein AB (spore_III_AB) HBM PF16591.5 EPA05531.1 - 0.005 16.3 0.9 0.042 13.3 0.0 2.0 1 1 1 2 2 2 1 Helical bimodular sensor domain Sec5 PF15469.6 EPA05531.1 - 0.0062 16.4 1.7 0.0062 16.4 1.7 2.1 1 1 1 2 2 2 1 Exocyst complex component Sec5 RRF PF01765.19 EPA05531.1 - 0.013 15.5 1.5 0.07 13.1 0.8 2.0 1 1 1 2 2 2 0 Ribosome recycling factor DDE_Tnp_ISL3 PF01610.17 EPA05531.1 - 0.038 13.7 11.1 0.14 11.9 0.3 2.1 1 1 1 2 2 2 0 Transposase Dak2 PF02734.17 EPA05531.1 - 0.062 13.2 0.0 0.21 11.5 0.0 1.8 1 1 1 2 2 2 0 DAK2 domain HNOB PF07700.15 EPA05531.1 - 0.11 12.5 2.1 0.19 11.6 1.9 1.6 1 1 0 1 1 1 0 Haem-NO-binding DUF1722 PF08349.11 EPA05531.1 - 0.16 12.3 2.0 0.92 9.8 0.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1722) OmpH PF03938.14 EPA05531.1 - 0.22 11.9 8.5 0.33 11.3 4.3 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) HU-CCDC81_bac_2 PF18175.1 EPA05531.1 - 0.24 11.3 3.4 31 4.5 0.1 3.5 2 1 2 4 4 4 0 CCDC81-like prokaryotic HU domain 2 DASH_Dad2 PF08654.10 EPA05531.1 - 0.26 11.7 9.7 4.5 7.7 0.2 2.8 1 1 2 3 3 3 0 DASH complex subunit Dad2 Sec34 PF04136.15 EPA05531.1 - 0.34 10.8 3.2 0.51 10.2 0.9 2.1 1 1 1 2 2 2 0 Sec34-like family Ribonuc_2-5A PF06479.12 EPA05531.1 - 0.48 10.6 5.3 1.2 9.3 3.9 2.2 1 1 0 1 1 1 0 Ribonuclease 2-5A DUF745 PF05335.13 EPA05531.1 - 0.5 10.1 5.2 0.36 10.5 1.6 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF745) FCH PF00611.23 EPA05531.1 - 0.53 10.6 5.4 4.6 7.6 3.4 2.9 1 1 1 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain YtxH PF12732.7 EPA05531.1 - 0.55 10.8 2.7 4.6 7.8 2.7 2.3 1 1 0 1 1 1 0 YtxH-like protein DUF2884 PF11101.8 EPA05531.1 - 1.5 8.3 11.0 2.6 7.5 11.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2884) BrnA_antitoxin PF14384.6 EPA05531.1 - 1.5 9.4 5.9 23 5.6 0.7 3.4 3 1 0 3 3 3 0 BrnA antitoxin of type II toxin-antitoxin system JHBP PF06585.11 EPA05531.1 - 3.8 6.6 8.3 43 3.2 1.1 2.5 1 1 2 3 3 3 0 Haemolymph juvenile hormone binding protein (JHBP) Methyltransf_25 PF13649.6 EPA05532.1 - 2.2e-16 60.3 0.0 4.2e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA05532.1 - 1.1e-14 54.8 0.0 1.9e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA05532.1 - 4.6e-12 46.0 0.1 6.3e-12 45.5 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EPA05532.1 - 3.8e-08 33.3 0.0 5.3e-08 32.9 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA05532.1 - 4.5e-07 30.5 0.0 7.9e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EPA05532.1 - 5.8e-05 22.5 0.1 7.6e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 EPA05532.1 - 0.00054 19.6 0.0 0.00089 18.9 0.0 1.3 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.13 EPA05532.1 - 0.0013 18.2 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TPMT PF05724.11 EPA05532.1 - 0.0033 17.1 0.0 0.0073 16.0 0.0 1.7 2 0 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) Ribosomal_L18_c PF14204.6 EPA05532.1 - 0.01 16.7 4.3 0.36 11.8 0.4 2.3 2 0 0 2 2 2 0 Ribosomal L18 C-terminal region MTS PF05175.14 EPA05532.1 - 0.064 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain TPR_11 PF13414.6 EPA05533.1 - 0.0097 15.6 0.5 6.6 6.5 0.1 3.2 3 0 0 3 3 3 1 TPR repeat YozE_SAM_like PF06855.12 EPA05533.1 - 0.049 13.8 0.9 38 4.6 0.0 3.4 3 0 0 3 3 3 0 YozE SAM-like fold DUF3080 PF11279.8 EPA05533.1 - 0.099 11.8 7.8 2.4 7.3 7.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3080) UPF0061 PF02696.14 EPA05533.1 - 0.11 11.2 5.0 0.13 11.0 5.0 1.2 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family DDE_Tnp_ISL3 PF01610.17 EPA05533.1 - 1.6 8.4 8.9 1.9 8.1 4.6 2.0 1 1 1 2 2 2 0 Transposase Muted PF14942.6 EPA05533.1 - 1.8 8.9 6.0 0.55 10.6 2.1 1.9 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein CTK3_C PF12350.8 EPA05533.1 - 4.4 7.5 8.5 1.1e+03 -0.1 8.5 2.8 1 1 0 1 1 1 0 CTD kinase subunit gamma CTK3 C-terminus RPAP3_C PF13877.6 EPA05533.1 - 5.4 7.6 6.9 1.8e+02 2.7 6.9 3.0 1 1 0 1 1 1 0 Potential Monad-binding region of RPAP3 DUF2024 PF09630.10 EPA05534.1 - 1.1e-34 118.2 2.8 1.2e-34 118.1 2.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2024) Ribonuc_red_sm PF00268.21 EPA05534.1 - 0.0072 15.8 0.1 0.0073 15.8 0.1 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Plant_NMP1 PF06694.11 EPA05534.1 - 0.094 11.8 0.2 0.1 11.7 0.2 1.1 1 0 0 1 1 1 0 Plant nuclear matrix protein 1 (NMP1) HSP70 PF00012.20 EPA05535.1 - 2.3e-196 653.6 12.9 3e-196 653.2 12.9 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EPA05535.1 - 1.8e-16 59.9 2.4 1.8e-16 59.9 2.4 1.9 2 1 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EPA05535.1 - 0.00043 20.1 0.0 0.00082 19.1 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Raco_middle PF17651.1 EPA05535.1 - 0.013 15.2 0.0 0.059 13.0 0.0 2.2 1 0 0 1 1 1 0 RACo middle region Peptidase_M22 PF00814.25 EPA05535.1 - 0.077 12.7 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Glycoprotease family DUF1885 PF08968.10 EPA05535.1 - 0.14 12.2 1.5 0.25 11.5 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1885) DUF1664 PF07889.12 EPA05535.1 - 1.2 9.2 5.0 0.48 10.5 0.9 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) TetR_C_19 PF17924.1 EPA05535.1 - 3.4 8.3 12.6 0.14 12.7 5.6 2.2 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain RP-C_C PF11800.8 EPA05535.1 - 10 6.2 10.1 0.59 10.2 3.7 2.0 2 0 0 2 2 2 0 Replication protein C C-terminal region DnaJ PF00226.31 EPA05536.1 - 8.5e-22 77.1 0.1 9.4e-22 76.9 0.1 1.0 1 0 0 1 1 1 1 DnaJ domain PUA PF01472.20 EPA05537.1 - 2.4e-09 37.0 0.0 5.8e-09 35.8 0.0 1.6 2 0 0 2 2 2 1 PUA domain TGT_C2 PF14810.6 EPA05537.1 - 1.2e-07 31.7 0.0 2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Patch-forming domain C2 of tRNA-guanine transglycosylase DUF460 PF04312.13 EPA05538.1 - 0.0019 17.9 0.0 0.0031 17.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF460) RuvX PF03652.15 EPA05538.1 - 0.055 13.9 0.0 0.28 11.6 0.0 2.0 2 0 0 2 2 2 0 Holliday junction resolvase NAC PF01849.18 EPA05539.1 - 1.5e-14 53.7 1.7 1.5e-14 53.7 1.7 1.6 2 0 0 2 2 2 1 NAC domain UBA_4 PF14555.6 EPA05539.1 - 0.011 15.6 0.1 0.015 15.1 0.1 1.2 1 0 0 1 1 1 0 UBA-like domain PhoU PF01895.19 EPA05540.1 - 1.7e-24 86.1 16.2 4.7e-17 62.2 2.6 2.4 2 0 0 2 2 2 2 PhoU domain MazE_antitoxin PF04014.18 EPA05540.1 - 1.1e-07 31.6 0.1 7.5e-07 28.9 0.0 2.5 2 0 0 2 2 2 1 Antidote-toxin recognition MazE, bacterial antitoxin WAC_Acf1_DNA_bd PF10537.9 EPA05540.1 - 0.042 14.4 0.1 0.084 13.4 0.1 1.6 1 0 0 1 1 1 0 ATP-utilising chromatin assembly and remodelling N-terminal DivIVA PF05103.13 EPA05542.1 - 0.00018 21.6 6.4 0.00023 21.3 6.4 1.1 1 0 0 1 1 1 1 DivIVA protein V-ATPase_G PF03179.15 EPA05542.1 - 0.0039 17.7 3.4 0.005 17.3 3.4 1.3 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit V-ATPase_G_2 PF16999.5 EPA05542.1 - 0.0087 16.5 6.2 0.27 11.7 0.4 2.3 1 1 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Apolipoprotein PF01442.18 EPA05542.1 - 0.015 15.2 2.4 0.02 14.7 2.4 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain COG6 PF06419.11 EPA05542.1 - 0.042 12.1 5.3 0.13 10.4 4.9 1.7 1 1 0 1 1 1 0 Conserved oligomeric complex COG6 CsoSCA PF08936.10 EPA05542.1 - 0.043 12.5 0.8 0.048 12.3 0.8 1.1 1 0 0 1 1 1 0 Carboxysome Shell Carbonic Anhydrase DUF948 PF06103.11 EPA05542.1 - 0.046 14.0 3.7 0.58 10.5 3.7 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 EPA05542.1 - 0.051 14.0 4.6 1.2 9.6 4.6 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein YabA PF06156.13 EPA05542.1 - 0.057 14.1 4.3 0.18 12.5 4.3 1.7 1 1 0 1 1 1 0 Initiation control protein YabA TFIIA_gamma_N PF02268.16 EPA05542.1 - 0.14 12.2 0.5 1 9.4 0.2 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIA, gamma subunit, helical domain YtxH PF12732.7 EPA05542.1 - 1.1 9.8 8.8 62 4.2 8.8 2.1 1 1 0 1 1 1 0 YtxH-like protein ARL2_Bind_BART PF11527.8 EPA05543.1 - 0.049 13.7 1.3 0.073 13.2 1.3 1.2 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART DUF3785 PF12653.7 EPA05546.1 - 0.069 13.3 0.0 0.082 13.0 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3785) zf-LSD1 PF06943.12 EPA05546.1 - 0.081 12.8 1.4 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 LSD1 zinc finger XPA_N PF01286.18 EPA05546.1 - 0.13 12.3 1.6 1 9.4 0.2 2.1 2 0 0 2 2 2 0 XPA protein N-terminal DUF2685 PF10886.8 EPA05546.1 - 0.21 11.8 2.2 0.37 11.0 2.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2685) zf_UBZ PF18439.1 EPA05546.1 - 0.57 9.8 2.6 7.2 6.3 0.4 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Acetyltransf_1 PF00583.25 EPA05547.1 - 6.4e-18 65.1 0.0 7.6e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EPA05547.1 - 1e-14 54.7 0.1 1.4e-14 54.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EPA05547.1 - 6.6e-14 51.9 0.0 8.9e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EPA05547.1 - 4.2e-07 30.2 0.2 5.2e-07 29.9 0.2 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EPA05547.1 - 0.00023 21.0 0.0 0.00036 20.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein PanZ PF12568.8 EPA05547.1 - 0.00073 19.3 0.0 0.00088 19.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_9 PF13527.7 EPA05547.1 - 0.00074 19.6 0.0 0.0013 18.8 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EPA05547.1 - 0.0017 18.4 0.0 0.0026 17.9 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 EPA05547.1 - 0.018 14.5 1.0 0.078 12.4 1.0 2.0 1 1 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_8 PF13523.6 EPA05547.1 - 0.059 13.1 0.0 0.094 12.4 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Peptidase_S8 PF00082.22 EPA05548.1 - 9.7e-21 74.3 7.7 2.1e-14 53.5 0.5 3.1 2 1 0 2 2 2 2 Subtilase family DZR PF12773.7 EPA05549.1 - 0.017 15.2 0.9 0.022 14.8 0.9 1.1 1 0 0 1 1 1 0 Double zinc ribbon PolC_DP2 PF03833.13 EPA05549.1 - 0.018 12.9 0.0 0.018 12.9 0.0 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 HypA PF01155.19 EPA05549.1 - 0.031 14.3 0.1 0.032 14.2 0.1 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C3HC4_3 PF13920.6 EPA05549.1 - 0.064 13.1 1.2 0.089 12.7 1.2 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FHIPEP PF00771.20 EPA05549.1 - 0.081 11.4 0.0 0.081 11.4 0.0 1.0 1 0 0 1 1 1 0 FHIPEP family zinc_ribbon_2 PF13240.6 EPA05549.1 - 0.17 11.6 2.6 6.7 6.6 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain FAM60A PF15396.6 EPA05550.1 - 2 8.4 14.3 2.6 8.0 14.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A SLC12 PF03522.15 EPA05550.1 - 2.6 7.0 17.2 2.8 6.9 17.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 ASD2 PF08687.11 EPA05550.1 - 3.8 7.0 10.1 4.7 6.7 10.1 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 SID-1_RNA_chan PF13965.6 EPA05550.1 - 4.3 5.6 13.1 4.7 5.5 13.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SPX PF03105.19 EPA05550.1 - 4.4 7.1 29.9 4.6 7.1 29.9 1.0 1 0 0 1 1 1 0 SPX domain CSG2 PF16965.5 EPA05550.1 - 6.9 5.5 10.0 8.8 5.1 10.0 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator Apt1 PF10351.9 EPA05550.1 - 7.8 5.2 27.8 9 5.0 27.8 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 EPA05550.1 - 9.1 4.9 22.7 9.5 4.9 22.7 1.1 1 0 0 1 1 1 0 Presenilin FAM76 PF16046.5 EPA05550.1 - 9.1 5.5 15.2 10 5.4 15.2 1.2 1 0 0 1 1 1 0 FAM76 protein NPR3 PF03666.13 EPA05550.1 - 9.2 4.9 19.0 11 4.6 19.0 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PNISR PF15996.5 EPA05550.1 - 9.4 6.4 14.8 12 6.2 14.8 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Oxidored_q2 PF00420.24 EPA05552.1 - 4.1e-22 77.8 6.1 5.4e-22 77.4 6.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L VPDSG-CTERM PF18205.1 EPA05552.1 - 1.6 8.6 5.6 16 5.4 0.0 2.8 3 0 0 3 3 3 0 VPDSG-CTERM motif NADHdh PF00146.21 EPA05553.1 - 5.7e-65 219.6 13.6 6.4e-65 219.4 13.6 1.0 1 0 0 1 1 1 1 NADH dehydrogenase Proton_antipo_M PF00361.20 EPA05554.1 - 5.4e-59 199.8 31.0 1.2e-54 185.5 30.5 3.0 3 0 0 3 3 3 2 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 EPA05554.1 - 2.1e-13 50.1 2.0 2.1e-13 50.1 2.0 2.6 2 0 0 2 2 2 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Proton_antipo_C PF01010.19 EPA05554.1 - 0.0075 15.9 0.1 0.014 15.1 0.1 1.4 1 0 0 1 1 1 1 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus Oxidored_q2 PF00420.24 EPA05554.1 - 0.055 13.1 0.3 0.055 13.1 0.3 4.7 4 2 0 4 4 4 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L PsbW PF07123.12 EPA05554.1 - 3.9 7.5 6.2 2.6 8.1 1.3 2.6 1 1 1 2 2 2 0 Photosystem II reaction centre W protein (PsbW) Proton_antipo_M PF00361.20 EPA05555.1 - 6.5e-61 206.1 24.6 6.5e-61 206.1 24.6 1.9 1 1 1 2 2 2 1 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 EPA05555.1 - 1.6e-05 24.9 0.3 0.00029 20.8 0.0 3.0 2 0 0 2 2 2 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus DUF1515 PF07439.11 EPA05555.1 - 0.15 12.1 1.3 1.2 9.2 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Oxidored_q3 PF00499.20 EPA05556.1 - 2.7e-22 79.0 14.2 4.1e-22 78.4 14.2 1.3 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 MIG-14_Wnt-bd PF06664.12 EPA05556.1 - 0.067 12.4 4.8 0.083 12.1 4.1 1.5 1 1 0 1 1 1 0 Wnt-binding factor required for Wnt secretion Fer4 PF00037.27 EPA05557.1 - 7.6e-12 44.5 10.8 3.2e-09 36.2 2.1 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 EPA05557.1 - 4.4e-09 36.3 16.8 3e-05 24.0 11.1 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 EPA05557.1 - 1e-08 35.6 9.4 1.6e-08 35.0 9.4 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 EPA05557.1 - 2e-08 34.2 20.1 4.2e-06 26.8 10.6 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EPA05557.1 - 1.3e-07 31.6 6.2 2.3e-07 30.9 6.2 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 EPA05557.1 - 9.1e-06 25.5 9.8 0.0014 18.6 1.6 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 EPA05557.1 - 1.9e-05 24.5 11.8 4.3e-05 23.4 1.7 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_4 PF12800.7 EPA05557.1 - 0.0001 22.6 8.1 0.012 16.0 0.9 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.6 EPA05557.1 - 0.00022 21.6 9.5 0.012 16.0 1.1 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 EPA05557.1 - 0.00098 20.0 9.7 0.0047 17.8 0.2 2.4 1 1 2 3 3 3 2 4Fe-4S double cluster binding domain Fer4_17 PF13534.6 EPA05557.1 - 0.0012 19.4 10.2 0.028 14.9 0.8 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_15 PF13459.6 EPA05557.1 - 0.0022 18.7 5.0 0.26 12.1 0.4 2.4 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_13 PF13370.6 EPA05557.1 - 0.0041 17.6 4.2 0.21 12.2 0.1 2.4 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 EPA05557.1 - 0.011 16.6 4.1 0.011 16.6 4.1 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 EPA05557.1 - 0.21 11.8 9.4 0.18 12.0 1.2 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_22 PF17179.4 EPA05557.1 - 1.7 9.5 10.9 0.58 11.0 0.8 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain SQAPI PF16845.5 EPA05558.1 - 0.044 14.1 0.1 14 6.1 0.0 2.3 1 1 1 2 2 2 0 Aspartic acid proteinase inhibitor EMP24_GP25L PF01105.24 EPA05558.1 - 0.056 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF4366 PF14283.6 EPA05558.1 - 0.2 11.7 0.6 1.5 8.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) NUDIX PF00293.28 EPA05559.1 - 8.2e-18 64.7 0.0 1.1e-17 64.3 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain AA_kinase PF00696.28 EPA05561.1 - 1.3e-30 106.8 0.0 1.5e-30 106.6 0.0 1.0 1 0 0 1 1 1 1 Amino acid kinase family RsgA_GTPase PF03193.16 EPA05561.1 - 0.035 14.0 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase DUF1967 PF09269.11 EPA05561.1 - 0.071 13.1 0.0 1.3 9.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1967) HHV-5_US34A PF17087.5 EPA05562.1 - 3.7 7.8 5.8 3.9 7.7 5.1 1.6 1 1 0 1 1 1 0 Herpesvirus US34A protein family Ribosomal_S2 PF00318.20 EPA05563.1 - 3.9e-20 72.0 0.4 8.2e-11 41.5 0.6 2.1 2 0 0 2 2 2 2 Ribosomal protein S2 Trypan_PARP PF05887.11 EPA05564.1 - 5.8e-05 23.1 2.5 5.8e-05 23.1 2.5 1.9 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) EB PF01683.18 EPA05564.1 - 0.0019 18.4 4.1 4.7 7.6 0.3 4.6 3 1 0 3 3 3 1 EB module MG2 PF01835.19 EPA05564.1 - 0.021 15.3 0.0 0.036 14.5 0.0 1.4 1 0 0 1 1 1 0 MG2 domain SPESP1 PF15754.5 EPA05564.1 - 0.041 13.1 0.2 0.067 12.4 0.2 1.3 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 Big_3_5 PF16640.5 EPA05564.1 - 0.061 13.5 1.9 0.15 12.2 1.9 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) CarboxypepD_reg PF13620.6 EPA05564.1 - 0.063 13.6 0.3 0.14 12.4 0.3 1.6 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain Neocarzinostat PF00960.18 EPA05564.1 - 0.071 13.1 1.7 0.15 12.1 0.6 2.1 1 1 1 2 2 2 0 Neocarzinostatin family HTH_55 PF18622.1 EPA05564.1 - 0.11 12.8 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 RctB helix turn helix domain Translin PF01997.16 EPA05565.1 - 7.3e-11 42.4 0.3 5.6e-09 36.3 0.1 2.3 1 1 1 2 2 2 2 Translin family ZT_dimer PF16916.5 EPA05566.1 - 6.4e-49 164.0 20.0 4.4e-19 68.4 0.2 3.2 3 0 0 3 3 3 3 Dimerisation domain of Zinc Transporter Cation_efflux PF01545.21 EPA05566.1 - 3.2e-40 138.0 17.8 4.2e-40 137.6 17.8 1.1 1 0 0 1 1 1 1 Cation efflux family Fe_dep_repr_C PF02742.15 EPA05566.1 - 0.16 12.1 5.8 8.8 6.5 0.4 3.9 4 0 0 4 4 4 0 Iron dependent repressor, metal binding and dimerisation domain AMP-binding_C_2 PF14535.6 EPA05566.1 - 1 9.7 9.4 1.9 8.9 1.5 3.1 2 1 1 3 3 3 0 AMP-binding enzyme C-terminal domain AIRC PF00731.20 EPA05567.1 - 4.3e-15 55.6 4.1 8.4e-15 54.6 4.1 1.5 1 0 0 1 1 1 1 AIR carboxylase NAD_kinase PF01513.21 EPA05567.1 - 0.0059 15.8 0.0 0.013 14.7 0.0 1.6 1 1 0 1 1 1 1 ATP-NAD kinase PrpR_N PF06506.11 EPA05567.1 - 0.015 14.9 1.6 0.18 11.4 0.2 2.4 2 0 0 2 2 2 0 Propionate catabolism activator HSCB_C PF07743.13 EPA05567.1 - 0.65 10.5 2.4 14 6.3 2.4 2.3 1 1 0 1 1 1 0 HSCB C-terminal oligomerisation domain Ribosomal_L38e PF01781.18 EPA05567.1 - 0.81 9.8 5.1 2 8.6 5.1 1.7 1 0 0 1 1 1 0 Ribosomal L38e protein family RNA_pol_N PF01194.17 EPA05568.1 - 1e-28 99.4 0.3 1.4e-28 98.9 0.3 1.2 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit tRNA-synt_2 PF00152.20 EPA05568.1 - 0.065 12.3 0.0 0.074 12.1 0.0 1.0 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) Cu-oxidase_3 PF07732.15 EPA05569.1 - 1.1e-22 80.2 6.5 8.6e-20 70.9 0.9 2.5 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EPA05569.1 - 2.4e-21 75.9 10.1 5.2e-11 42.4 0.4 3.2 2 1 0 2 2 2 2 Multicopper oxidase TSP_3 PF02412.18 EPA05570.1 - 3.2e-05 23.5 4.4 3.2e-05 23.5 4.4 2.1 2 0 0 2 2 2 2 Thrombospondin type 3 repeat TerY_C PF15616.6 EPA05571.1 - 0.019 15.1 0.1 0.023 14.8 0.1 1.2 1 0 0 1 1 1 0 TerY-C metal binding domain Lactamase_B PF00753.27 EPA05572.1 - 8.3e-22 78.2 3.7 9e-20 71.5 3.7 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EPA05572.1 - 2.1e-05 24.2 0.1 3.2e-05 23.5 0.1 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain COR PF16095.5 EPA05572.1 - 0.011 15.5 0.3 0.017 14.9 0.3 1.3 1 0 0 1 1 1 0 C-terminal of Roc, COR, domain DUF1776 PF08643.10 EPA05572.1 - 0.055 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) S4 PF01479.25 EPA05573.1 - 2e-10 40.2 0.1 8.2e-10 38.3 0.0 2.0 2 0 0 2 2 2 1 S4 domain DUF111 PF01969.17 EPA05574.1 - 2e-100 336.5 0.6 2.2e-100 336.3 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF111 Scaffolding_pro PF11418.8 EPA05574.1 - 0.049 14.2 0.1 0.15 12.7 0.1 1.8 1 0 0 1 1 1 0 Phi29 scaffolding protein Ribosomal_S13 PF00416.22 EPA05576.1 - 5.9e-38 130.1 0.0 7e-38 129.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 HHH_6 PF14579.6 EPA05576.1 - 0.048 13.9 0.0 0.078 13.2 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF4238 PF14022.6 EPA05576.1 - 0.093 12.2 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4238) DBI_PRT PF02277.17 EPA05578.1 - 1.1e-13 51.2 0.1 1.6e-13 50.6 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyltransferase QueC PF06508.13 EPA05579.1 - 6.8e-09 35.5 0.4 4.1e-08 33.0 0.2 2.2 2 1 1 3 3 3 1 Queuosine biosynthesis protein QueC ATP_bind_3 PF01171.20 EPA05579.1 - 4.1e-08 33.2 0.1 3e-07 30.4 0.1 2.0 1 1 0 1 1 1 1 PP-loop family NAD_synthase PF02540.17 EPA05579.1 - 6.9e-08 31.9 0.0 1.1e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 NAD synthase tRNA_Me_trans PF03054.16 EPA05579.1 - 1.5e-07 30.5 0.3 2.5e-06 26.5 0.2 2.2 2 0 0 2 2 2 1 tRNA methyl transferase Asn_synthase PF00733.21 EPA05579.1 - 2.9e-07 30.5 0.0 9.1e-07 28.8 0.0 1.7 2 0 0 2 2 2 1 Asparagine synthase ThiI PF02568.14 EPA05579.1 - 9.3e-05 22.1 0.1 0.00017 21.2 0.1 1.5 1 1 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.19 EPA05579.1 - 0.034 13.4 0.3 0.067 12.5 0.1 1.5 2 0 0 2 2 2 0 Arginosuccinate synthase Ldh_1_N PF00056.23 EPA05580.1 - 4.4e-36 124.1 0.5 8.4e-36 123.2 0.5 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EPA05580.1 - 2.9e-28 98.9 0.1 5e-28 98.1 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Zip PF02535.22 EPA05581.1 - 8.6e-06 25.2 19.0 8.6e-06 25.2 19.0 2.5 1 1 1 2 2 2 1 ZIP Zinc transporter DUF2070 PF09843.9 EPA05581.1 - 0.91 7.7 21.4 0.08 11.2 6.0 2.5 2 1 1 3 3 3 0 Predicted membrane protein (DUF2070) MG2 PF01835.19 EPA05583.1 - 0.00042 20.7 0.0 0.0056 17.1 0.0 2.9 3 0 0 3 3 3 1 MG2 domain STI1 PF17830.1 EPA05583.1 - 0.11 12.5 0.3 0.52 10.3 0.2 2.1 2 0 0 2 2 2 0 STI1 domain HTH_10 PF04967.12 EPA05583.1 - 0.16 11.8 0.1 16 5.4 0.0 2.5 2 0 0 2 2 2 0 HTH DNA binding domain Tachystatin_B PF11478.8 EPA05583.1 - 0.21 11.6 0.3 0.42 10.6 0.3 1.4 1 0 0 1 1 1 0 Antimicrobial chitin binding protein tachystatin B Enolase_C PF00113.22 EPA05585.1 - 1.3e-57 195.3 0.1 1.8e-57 194.9 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EPA05585.1 - 3.2e-21 75.9 0.0 8.9e-21 74.4 0.0 1.8 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EPA05585.1 - 8.3e-05 22.3 0.0 0.00025 20.7 0.0 1.7 1 1 1 2 2 2 1 Enolase C-terminal domain-like DUF155 PF02582.14 EPA05585.1 - 0.09 12.9 0.0 0.24 11.5 0.0 1.6 1 1 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 GHMP_kinases_N PF00288.26 EPA05586.1 - 2e-17 63.2 0.2 3.3e-17 62.5 0.2 1.4 1 0 0 1 1 1 1 GHMP kinases N terminal domain GalKase_gal_bdg PF10509.9 EPA05586.1 - 0.003 17.1 0.0 0.0076 15.8 0.0 1.7 1 0 0 1 1 1 1 Galactokinase galactose-binding signature SIS PF01380.22 EPA05587.1 - 4.3e-50 168.9 3.6 3.2e-25 88.5 2.6 2.6 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EPA05587.1 - 1e-21 77.6 0.0 5.2e-21 75.2 0.0 2.1 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EPA05587.1 - 4.8e-16 58.8 0.4 2.2e-15 56.7 0.0 2.3 3 0 0 3 3 3 1 Glutamine amidotransferase domain SIS_2 PF13580.6 EPA05587.1 - 1.1e-06 28.7 3.3 0.00039 20.4 0.6 3.6 2 1 1 3 3 3 2 SIS domain GATase_4 PF13230.6 EPA05587.1 - 8.1e-05 21.7 0.0 0.00013 21.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Memo PF01875.17 EPA05588.1 - 3.6e-82 275.5 0.0 4.1e-82 275.4 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein LigB PF02900.18 EPA05588.1 - 0.0034 16.5 0.0 0.0044 16.1 0.0 1.2 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Radical_SAM PF04055.21 EPA05589.1 - 8.1e-09 36.1 0.0 1.8e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily B12-binding PF02310.19 EPA05589.1 - 0.056 13.5 0.1 0.17 11.9 0.0 1.8 1 1 0 1 1 1 0 B12 binding domain polyprenyl_synt PF00348.17 EPA05590.1 - 1.4e-70 237.3 0.1 1.7e-70 237.0 0.1 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Terpene_synth_C PF03936.16 EPA05590.1 - 0.00092 18.6 0.0 0.0017 17.8 0.0 1.4 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain GHMP_kinases_C PF08544.13 EPA05591.1 - 1.9e-14 53.8 0.1 2.3e-14 53.5 0.1 1.1 1 0 0 1 1 1 1 GHMP kinases C terminal Aminotran_5 PF00266.19 EPA05592.1 - 6.7e-91 305.0 0.1 7.9e-91 304.8 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EPA05592.1 - 2.1e-07 30.5 0.0 3.4e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EPA05592.1 - 0.00016 21.1 0.0 0.00029 20.2 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 EPA05592.1 - 0.0027 16.3 0.0 0.004 15.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Pyridoxal_deC PF00282.19 EPA05592.1 - 0.054 12.2 0.0 0.12 11.0 0.0 1.6 2 0 0 2 2 2 0 Pyridoxal-dependent decarboxylase conserved domain YjeF_N PF03853.15 EPA05593.1 - 1.4e-46 158.5 0.0 1.6e-46 158.3 0.0 1.0 1 0 0 1 1 1 1 YjeF-related protein N-terminus CxxCxxCC PF03692.15 EPA05594.1 - 7.9e-09 36.1 0.4 1.5e-08 35.2 0.4 1.4 1 0 0 1 1 1 1 Putative zinc- or iron-chelating domain TMEM51 PF15345.6 EPA05597.1 - 4.9e-06 26.6 0.1 5.4e-06 26.4 0.1 1.0 1 0 0 1 1 1 1 Transmembrane protein 51 Oxidored_q3 PF00499.20 EPA05597.1 - 0.0021 17.8 0.1 0.0027 17.4 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Tetraspanin PF00335.20 EPA05597.1 - 0.0028 17.4 0.3 0.0034 17.1 0.3 1.0 1 0 0 1 1 1 1 Tetraspanin family MnhB PF04039.13 EPA05597.1 - 0.0065 16.8 0.1 0.12 12.7 0.0 2.0 2 0 0 2 2 2 1 Domain related to MnhB subunit of Na+/H+ antiporter COX2_TM PF02790.15 EPA05597.1 - 0.032 14.4 0.1 1.3 9.3 0.0 2.0 1 1 1 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain SfLAP PF11139.8 EPA05597.1 - 0.067 12.6 0.0 0.084 12.3 0.0 1.2 1 0 0 1 1 1 0 Sap, sulfolipid-1-addressing protein 7tm_3 PF00003.22 EPA05597.1 - 0.095 12.4 0.0 0.11 12.2 0.0 1.0 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR OSTbeta PF15048.6 EPA05597.1 - 0.095 12.8 0.3 0.2 11.8 0.0 1.7 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein DUF2207 PF09972.9 EPA05597.1 - 0.16 10.7 0.0 0.21 10.3 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF202 PF02656.15 EPA05597.1 - 0.17 12.4 0.7 0.36 11.3 0.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Gram_pos_anchor PF00746.21 EPA05597.1 - 0.49 10.4 7.0 0.64 10.0 0.4 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif ATP1G1_PLM_MAT8 PF02038.16 EPA05597.1 - 0.59 9.6 0.0 0.59 9.6 0.0 2.1 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family DUF3899 PF13038.6 EPA05597.1 - 1 9.9 4.0 18 5.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) DUF872 PF05915.12 EPA05597.1 - 1.7 8.8 4.8 12 6.1 0.1 2.1 1 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) DUF4064 PF13273.6 EPA05597.1 - 3.2 8.1 9.3 49 4.3 9.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) HTH_24 PF13412.6 EPA05598.1 - 2.2e-12 46.3 2.3 2.2e-12 46.3 2.3 2.0 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 EPA05598.1 - 3e-12 46.2 1.3 4.6e-12 45.6 1.3 1.3 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.21 EPA05598.1 - 1.5e-11 44.1 0.1 2.4e-11 43.4 0.1 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_11 PF08279.12 EPA05598.1 - 4.1e-05 23.4 0.4 4.1e-05 23.4 0.4 1.8 2 0 0 2 2 2 1 HTH domain HTH_Crp_2 PF13545.6 EPA05598.1 - 0.00074 19.5 0.2 0.0014 18.5 0.2 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_50 PF18024.1 EPA05598.1 - 0.0013 18.3 0.1 0.0048 16.5 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_20 PF12840.7 EPA05598.1 - 0.011 15.8 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_10 PF04967.12 EPA05598.1 - 0.014 15.2 1.1 0.02 14.7 0.3 1.7 2 0 0 2 2 2 0 HTH DNA binding domain NUMOD1 PF07453.13 EPA05598.1 - 0.017 15.3 0.1 2.4 8.5 0.0 2.5 2 0 0 2 2 2 0 NUMOD1 domain DDRGK PF09756.9 EPA05598.1 - 0.021 14.4 0.7 0.049 13.2 0.2 1.7 1 1 1 2 2 2 0 DDRGK domain MarR_2 PF12802.7 EPA05598.1 - 0.021 14.7 0.1 0.035 14.0 0.1 1.3 1 0 0 1 1 1 0 MarR family GntR PF00392.21 EPA05598.1 - 0.048 13.3 0.2 0.078 12.6 0.2 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family MarR PF01047.22 EPA05598.1 - 0.052 13.5 0.2 0.1 12.5 0.2 1.5 1 0 0 1 1 1 0 MarR family HTH_3 PF01381.22 EPA05598.1 - 0.19 11.8 1.9 0.73 9.9 0.1 2.7 3 1 0 3 3 3 0 Helix-turn-helix Sec3_C_2 PF15278.6 EPA05599.1 - 0.014 15.7 0.4 0.014 15.7 0.4 1.0 1 0 0 1 1 1 0 Sec3 exocyst complex subunit TcdB_N PF12918.7 EPA05599.1 - 0.032 14.5 2.4 0.038 14.3 2.4 1.1 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain DpnI_C PF17726.1 EPA05599.1 - 0.059 13.5 0.5 0.064 13.4 0.5 1.1 1 0 0 1 1 1 0 Dam-replacing HTH domain Zincin_1 PF06262.11 EPA05601.1 - 0.037 14.1 0.4 0.82 9.8 0.0 2.6 2 1 0 2 2 2 0 Zincin-like metallopeptidase Transglut_C PF00927.22 EPA05604.1 - 0.021 15.0 0.0 0.032 14.4 0.0 1.2 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain ASH PF15780.5 EPA05604.1 - 0.065 13.5 0.2 0.1 12.8 0.2 1.3 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Sec2p PF06428.11 EPA05605.1 - 0.0098 15.8 2.2 0.017 15.1 2.2 1.4 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p ATP-synt_E_2 PF08112.11 EPA05605.1 - 0.052 13.8 6.2 0.079 13.3 6.2 1.3 1 0 0 1 1 1 0 ATP synthase epsilon subunit VitK2_biosynth PF02621.14 EPA05606.1 - 6.8e-80 268.4 0.0 7.6e-80 268.2 0.0 1.0 1 0 0 1 1 1 1 Menaquinone biosynthesis Imm26 PF15428.6 EPA05606.1 - 0.043 14.1 0.0 0.085 13.1 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 26 SCAB_CC PF16712.5 EPA05606.1 - 0.062 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Coiled-coil regions of plant-specific actin-binding protein HD PF01966.22 EPA05607.1 - 0.0072 16.5 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 HD domain PDEase_I PF00233.19 EPA05607.1 - 0.022 14.5 1.3 0.046 13.5 0.4 1.9 2 0 0 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase HD_2 PF12917.7 EPA05607.1 - 0.042 13.6 0.2 0.78 9.5 0.0 2.3 2 0 0 2 2 2 0 HD containing hydrolase-like enzyme DUF1091 PF06477.13 EPA05607.1 - 0.052 14.0 0.1 0.14 12.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) YliH PF10799.8 EPA05609.1 - 0.032 14.1 1.2 0.035 14.1 1.2 1.0 1 0 0 1 1 1 0 Biofilm formation protein (YliH/bssR) COG2 PF06148.11 EPA05609.1 - 0.051 13.7 5.3 0.05 13.7 5.3 1.1 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Nas2_N PF18265.1 EPA05609.1 - 0.38 10.7 6.0 0.57 10.1 5.4 1.6 1 1 1 2 2 2 0 Nas2 N_terminal domain Tli4_N PF18443.1 EPA05609.1 - 0.96 9.8 8.0 0.97 9.8 8.0 1.0 1 0 0 1 1 1 0 Tle cognate immunity protein 4 N-terminal domain DUF4407 PF14362.6 EPA05609.1 - 1.1 8.5 6.6 1.2 8.5 6.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Nup88 PF10168.9 EPA05609.1 - 2.4 5.9 13.1 2.3 5.9 13.1 1.0 1 0 0 1 1 1 0 Nuclear pore component YfhO PF09586.10 EPA05609.1 - 2.8 6.0 5.9 3.3 5.8 5.9 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO eIF-4B PF06273.11 EPA05609.1 - 3.6 6.5 12.8 3.8 6.4 12.8 1.0 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B MscS_TM PF12794.7 EPA05609.1 - 3.7 6.3 4.4 3.7 6.3 4.4 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 MSV199 PF10553.9 EPA05609.1 - 5.1 7.3 14.6 5.4 7.3 14.6 1.0 1 0 0 1 1 1 0 MSV199 domain Atg14 PF10186.9 EPA05609.1 - 6.6 5.7 17.8 6.7 5.7 17.8 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 zf-ribbon_3 PF13248.6 EPA05610.1 - 0.013 14.9 2.6 3.3 7.3 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-UDP PF14569.6 EPA05610.1 - 0.017 15.2 1.0 0.025 14.7 1.0 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-ISL3 PF14690.6 EPA05610.1 - 0.021 15.5 0.6 2.6 8.8 0.0 2.3 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 C1_1 PF00130.22 EPA05610.1 - 0.14 12.0 4.6 0.24 11.3 4.6 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_4 PF14570.6 EPA05610.1 - 0.15 11.9 8.6 0.79 9.6 8.9 1.8 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain PI3K_P85_iSH2 PF16454.5 EPA05611.1 - 0.0013 18.3 4.7 0.0016 18.0 4.7 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4472 PF14739.6 EPA05611.1 - 0.0018 19.0 3.5 0.0021 18.8 3.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4472) Flagellar_rod PF05149.12 EPA05611.1 - 0.0024 17.4 4.5 0.0027 17.2 4.5 1.0 1 0 0 1 1 1 1 Paraflagellar rod protein CLZ PF16526.5 EPA05611.1 - 0.0028 18.0 5.1 0.022 15.1 1.4 2.1 1 1 1 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels COG6 PF06419.11 EPA05611.1 - 0.0036 15.6 3.0 0.0042 15.4 3.0 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 ABC_tran_CTD PF16326.5 EPA05611.1 - 0.0045 17.2 3.3 0.07 13.4 3.3 2.0 1 1 0 1 1 1 1 ABC transporter C-terminal domain DUF724 PF05266.14 EPA05611.1 - 0.0082 16.0 4.4 0.0084 15.9 4.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF724) GAS PF13851.6 EPA05611.1 - 0.011 15.0 5.6 0.016 14.5 5.6 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding TMPIT PF07851.13 EPA05611.1 - 0.019 14.3 2.8 0.02 14.1 2.8 1.0 1 0 0 1 1 1 0 TMPIT-like protein ADIP PF11559.8 EPA05611.1 - 0.026 14.6 4.6 0.029 14.5 4.6 1.0 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 EPA05611.1 - 0.03 14.8 5.1 0.033 14.7 5.1 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region GLTP PF08718.11 EPA05611.1 - 0.034 14.4 1.4 0.034 14.4 1.4 1.1 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) CCDC-167 PF15188.6 EPA05611.1 - 0.037 14.4 4.6 0.048 14.0 4.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 BLOC1_2 PF10046.9 EPA05611.1 - 0.053 13.8 3.5 0.17 12.2 0.4 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 EPA05611.1 - 0.054 13.5 3.1 0.058 13.4 3.1 1.1 1 0 0 1 1 1 0 Laminin Domain II DUF1664 PF07889.12 EPA05611.1 - 0.069 13.2 3.1 0.12 12.4 3.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) SlyX PF04102.12 EPA05611.1 - 0.074 13.7 3.9 1.1 9.9 3.9 2.0 1 1 0 1 1 1 0 SlyX Vac_Fusion PF02346.16 EPA05611.1 - 0.092 12.4 5.9 2.6 7.7 4.9 2.1 1 1 1 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 Nup88 PF10168.9 EPA05611.1 - 0.11 10.3 6.0 0.13 10.1 6.0 1.0 1 0 0 1 1 1 0 Nuclear pore component Exog_C PF18026.1 EPA05611.1 - 0.11 12.5 2.7 0.71 10.0 0.4 2.3 2 1 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain EMP24_GP25L PF01105.24 EPA05611.1 - 0.12 12.4 2.9 0.2 11.6 2.9 1.5 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Allexi_40kDa PF05549.11 EPA05611.1 - 0.17 11.3 2.4 0.22 11.0 2.4 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein ACCA PF03255.14 EPA05611.1 - 0.18 11.7 2.6 0.22 11.4 2.6 1.2 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Inositol_P PF00459.25 EPA05611.1 - 0.2 11.2 0.6 0.19 11.2 0.6 1.0 1 0 0 1 1 1 0 Inositol monophosphatase family DivIC PF04977.15 EPA05611.1 - 0.22 11.3 6.8 29 4.5 6.8 2.1 1 1 0 1 1 1 0 Septum formation initiator FlaC_arch PF05377.11 EPA05611.1 - 0.42 11.0 5.3 1.7 9.1 3.4 2.1 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) XhlA PF10779.9 EPA05611.1 - 1.7 8.9 9.4 6.1 7.1 7.6 2.0 1 1 1 2 2 2 0 Haemolysin XhlA BRI3BP PF14965.6 EPA05611.1 - 2 7.9 4.5 1.7 8.1 1.3 1.9 1 1 1 2 2 2 0 Negative regulator of p53/TP53 TrkH PF02386.16 EPA05612.1 - 6.8e-24 84.2 23.7 1.4e-17 63.3 6.6 2.3 1 1 1 2 2 2 2 Cation transport protein CBS PF00571.28 EPA05612.1 - 1e-17 64.3 3.0 1.8e-10 41.1 0.2 2.5 2 0 0 2 2 2 2 CBS domain GTP_EFTU PF00009.27 EPA05615.1 - 4e-60 202.7 0.6 6.4e-60 202.0 0.6 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EPA05615.1 - 2.8e-21 75.3 0.0 9.2e-21 73.7 0.0 2.0 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 EPA05615.1 - 1.2e-20 73.5 0.0 6.1e-20 71.2 0.0 2.2 1 1 1 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.6 EPA05615.1 - 1.2e-20 73.4 0.7 3.2e-20 72.0 0.7 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EPA05615.1 - 2.1e-12 47.2 0.1 8.7e-12 45.3 0.1 2.2 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EPA05615.1 - 0.027 14.6 0.0 0.061 13.4 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase RF3_C PF16658.5 EPA05615.1 - 0.041 13.7 0.0 0.091 12.6 0.0 1.6 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain DUF4393 PF14337.6 EPA05615.1 - 0.057 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4393) TPR_1 PF00515.28 EPA05616.1 - 3.3e-23 80.5 8.3 2.1e-06 27.3 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EPA05616.1 - 3.2e-21 73.7 4.2 5.4e-05 23.0 0.1 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 EPA05616.1 - 2.3e-14 52.3 4.3 0.00029 20.8 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EPA05616.1 - 1.4e-13 50.3 4.0 0.0016 18.1 0.0 4.1 1 1 3 4 4 4 3 TPR repeat TPR_14 PF13428.6 EPA05616.1 - 1.3e-10 41.2 0.0 0.094 13.6 0.0 4.1 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EPA05616.1 - 2.1e-10 40.3 2.5 0.08 13.4 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EPA05616.1 - 3.1e-10 40.2 1.5 4.4e-05 23.7 0.2 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EPA05616.1 - 3.8e-09 36.5 0.0 0.00029 20.9 0.0 2.3 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EPA05616.1 - 6.9e-09 35.1 0.4 0.015 15.3 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EPA05616.1 - 8.3e-09 36.0 0.0 0.0029 18.2 0.0 2.5 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EPA05616.1 - 8.9e-08 32.5 0.5 0.0019 18.7 0.1 3.0 2 1 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EPA05616.1 - 2.7e-07 30.7 0.6 4.3e-05 23.6 0.1 2.2 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 EPA05616.1 - 5.2e-07 29.6 0.4 0.58 10.3 0.0 4.1 4 0 0 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EPA05616.1 - 1.4e-06 28.0 0.0 0.64 10.0 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_3 PF07720.12 EPA05616.1 - 2e-06 27.7 2.9 3.6e-05 23.7 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EPA05616.1 - 0.00012 22.4 0.6 1.4 9.7 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF3856 PF12968.7 EPA05616.1 - 0.0002 21.4 0.0 4.7 7.3 0.0 3.3 1 1 2 3 3 3 2 Domain of Unknown Function (DUF3856) MIT PF04212.18 EPA05616.1 - 0.00023 21.1 1.3 0.68 10.0 0.1 4.0 4 1 0 4 4 4 1 MIT (microtubule interacting and transport) domain CODH_A_N PF18537.1 EPA05616.1 - 0.084 12.9 0.0 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain DUF531 PF04407.12 EPA05616.1 - 0.12 12.5 0.0 0.14 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF531) PPR PF01535.20 EPA05616.1 - 0.12 12.6 0.1 8.4 6.9 0.1 3.0 3 0 0 3 3 2 0 PPR repeat SIS PF01380.22 EPA05617.1 - 3e-10 40.0 3.0 3.6e-08 33.3 0.0 3.0 2 1 0 2 2 2 2 SIS domain OTT_1508_deam PF14441.6 EPA05618.1 - 0.0011 18.9 0.3 0.0014 18.6 0.3 1.2 1 0 0 1 1 1 1 OTT_1508-like deaminase zf-C2H2_jaz PF12171.8 EPA05618.1 - 0.026 14.8 0.6 0.026 14.8 0.6 2.0 1 1 1 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EPA05618.1 - 0.093 13.2 2.6 0.1 13.1 1.3 1.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type CagY_M PF07337.11 EPA05619.1 - 2.7 7.7 5.9 7.1 6.3 0.1 3.2 3 0 0 3 3 3 0 DC-EC Repeat Usp PF00582.26 EPA05620.1 - 1.1e-26 94.0 0.0 1.4e-26 93.7 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family GARS_N PF02844.15 EPA05620.1 - 0.0011 19.6 0.1 0.0021 18.8 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain Peptidase_M15_4 PF13539.6 EPA05620.1 - 0.14 12.7 0.1 0.32 11.5 0.1 1.6 1 1 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase TFIIB PF00382.19 EPA05621.1 - 9.2e-31 105.7 6.1 4.4e-16 58.7 0.4 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EPA05621.1 - 3.8e-10 39.1 1.1 6.2e-10 38.4 1.1 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 EPA05621.1 - 0.0022 18.1 0.0 2.7 8.1 0.0 2.3 2 0 0 2 2 2 2 Cyclin, C-terminal domain Sigma70_r4 PF04545.16 EPA05621.1 - 0.0045 16.5 0.0 0.45 10.1 0.0 3.5 3 1 1 4 4 4 1 Sigma-70, region 4 RPW8 PF05659.11 EPA05621.1 - 0.0064 16.2 0.1 0.012 15.2 0.1 1.4 1 0 0 1 1 1 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 Cyclin_N PF00134.23 EPA05621.1 - 0.0066 16.2 0.8 0.061 13.1 0.2 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain HTH_11 PF08279.12 EPA05621.1 - 0.0084 16.0 1.1 0.092 12.7 0.0 2.7 3 0 0 3 3 3 1 HTH domain HTH_AsnC-type PF13404.6 EPA05621.1 - 0.0093 15.8 0.0 0.24 11.3 0.0 2.8 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain RB_B PF01857.20 EPA05621.1 - 0.011 15.8 0.1 0.02 14.9 0.1 1.5 1 1 0 1 1 1 0 Retinoblastoma-associated protein B domain zf-ribbon_3 PF13248.6 EPA05621.1 - 0.043 13.3 2.7 0.22 11.0 2.7 2.1 1 1 0 1 1 1 0 zinc-ribbon domain Sigma70_r4_2 PF08281.12 EPA05621.1 - 0.19 11.4 1.5 5.4 6.8 0.0 3.2 3 0 0 3 3 3 0 Sigma-70, region 4 zf-NADH-PPase PF09297.11 EPA05621.1 - 0.25 11.1 1.5 1.4 8.6 0.2 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.6 EPA05621.1 - 1.2 9.0 4.1 0.7 9.7 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Radical_SAM PF04055.21 EPA05622.1 - 1.3e-17 64.6 0.0 3e-17 63.5 0.0 1.6 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 EPA05622.1 - 0.0061 16.7 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Zn_ribbon_SprT PF17283.2 EPA05623.1 - 0.022 14.6 1.5 1.7 8.6 0.1 2.1 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Auto_anti-p27 PF06677.12 EPA05623.1 - 0.054 13.7 1.6 0.52 10.5 0.0 2.2 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) VP_N-CPKC PF11475.8 EPA05623.1 - 0.11 12.5 0.2 0.51 10.3 0.0 1.9 2 0 0 2 2 2 0 Virion protein N terminal domain DnaJ PF00226.31 EPA05624.1 - 2.7e-21 75.4 7.4 2.7e-21 75.4 7.4 2.0 2 1 0 2 2 2 1 DnaJ domain HSP9_HSP12 PF04119.12 EPA05624.1 - 0.025 15.0 1.8 0.038 14.4 0.6 1.9 1 1 0 1 1 1 0 Heat shock protein 9/12 CD20 PF04103.15 EPA05624.1 - 0.035 14.2 0.0 0.07 13.2 0.0 1.6 1 1 0 1 1 1 0 CD20-like family SUIM_assoc PF16619.5 EPA05624.1 - 0.061 13.4 0.2 0.17 12.0 0.2 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 TPR_1 PF00515.28 EPA05625.1 - 6.5e-16 57.4 0.1 3.4e-09 36.1 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EPA05625.1 - 1.7e-14 52.7 0.0 9.8e-08 31.6 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EPA05625.1 - 5.8e-12 44.8 0.0 3.7e-08 32.9 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EPA05625.1 - 7.6e-11 41.5 0.0 0.00012 21.6 0.0 2.1 1 1 1 2 2 2 2 TPR repeat TPR_16 PF13432.6 EPA05625.1 - 7.1e-10 39.4 0.0 8e-10 39.2 0.0 1.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 EPA05625.1 - 6.1e-09 35.3 0.0 0.00012 21.8 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EPA05625.1 - 4.1e-08 33.2 0.1 4.9e-08 33.0 0.1 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 EPA05625.1 - 1.7e-07 31.7 0.0 1.8e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 EPA05625.1 - 5.9e-07 29.7 0.2 0.00053 20.2 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EPA05625.1 - 2e-06 27.7 0.1 7.7e-06 25.9 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EPA05625.1 - 3.8e-06 27.3 0.1 0.011 16.5 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EPA05625.1 - 0.00031 20.9 0.0 0.00033 20.8 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EPA05625.1 - 0.0011 18.7 0.0 0.28 11.1 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat NRBF2_MIT PF17169.4 EPA05625.1 - 0.015 15.5 0.0 0.56 10.5 0.0 2.1 1 1 1 2 2 2 0 MIT domain of nuclear receptor-binding factor 2 MIT PF04212.18 EPA05625.1 - 0.02 15.0 0.0 1.3 9.1 0.0 2.1 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain NARP1 PF12569.8 EPA05625.1 - 0.032 13.2 0.0 0.035 13.0 0.0 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 EPA05625.1 - 0.034 14.8 0.0 0.97 10.2 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 EPA05625.1 - 0.041 14.0 0.0 0.047 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) Fis1_TPR_C PF14853.6 EPA05625.1 - 0.066 13.3 0.1 0.37 10.9 0.0 2.0 1 1 2 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Coatomer_E PF04733.14 EPA05625.1 - 0.069 12.6 0.0 0.13 11.6 0.0 1.4 1 1 0 1 1 1 0 Coatomer epsilon subunit PPR PF01535.20 EPA05625.1 - 0.14 12.4 0.2 1.8 9.0 0.0 2.2 2 0 0 2 2 2 0 PPR repeat GATase PF00117.28 EPA05628.1 - 1.5e-25 90.1 0.0 1.8e-25 89.8 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EPA05628.1 - 1.2e-05 25.2 0.0 0.0004 20.2 0.0 2.7 1 1 0 1 1 1 1 Peptidase C26 SNO PF01174.19 EPA05628.1 - 0.00032 20.6 0.0 0.0033 17.3 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 EPA05628.1 - 0.0012 18.5 0.0 0.0022 17.6 0.0 1.4 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain His_biosynth PF00977.21 EPA05629.1 - 8.2e-41 139.9 0.2 9e-41 139.8 0.2 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.14 EPA05629.1 - 0.11 11.7 0.1 3.6 6.8 0.0 1.9 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG IGPD PF00475.18 EPA05630.1 - 1.9e-26 93.1 0.0 2.1e-26 92.9 0.0 1.0 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase ANF_receptor PF01094.28 EPA05630.1 - 0.051 12.7 0.0 0.059 12.5 0.0 1.1 1 0 0 1 1 1 0 Receptor family ligand binding region DNase-RNase PF02577.14 EPA05631.1 - 4e-12 45.9 0.0 4.6e-12 45.7 0.0 1.0 1 0 0 1 1 1 1 Bifunctional nuclease HTH_19 PF12844.7 EPA05631.1 - 0.11 12.6 0.2 0.63 10.1 0.0 2.1 2 1 1 3 3 3 0 Helix-turn-helix domain Ribosomal_L7Ae PF01248.26 EPA05631.1 - 0.16 11.7 0.5 0.29 10.9 0.3 1.5 2 0 0 2 2 2 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CBS PF00571.28 EPA05633.1 - 2.4e-37 127.2 1.6 8.2e-10 39.0 0.0 4.1 4 0 0 4 4 4 4 CBS domain DUF5521 PF17659.1 EPA05633.1 - 0.058 11.2 0.0 0.07 11.0 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5521) RMMBL PF07521.12 EPA05634.1 - 0.0056 16.6 0.0 0.016 15.1 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Response_reg PF00072.24 EPA05635.1 - 1.3e-16 60.7 0.1 1.5e-16 60.6 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain DUF1188 PF06690.11 EPA05635.1 - 0.059 12.9 0.0 0.062 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) AsnC_trans_reg PF01037.21 EPA05636.1 - 6.4e-11 42.1 0.1 7.2e-11 41.9 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain RimK PF08443.11 EPA05636.1 - 0.019 14.5 0.2 0.02 14.5 0.2 1.1 1 0 0 1 1 1 0 RimK-like ATP-grasp domain ACT_5 PF13710.6 EPA05636.1 - 0.09 12.6 0.7 5.9 6.8 0.0 2.1 2 0 0 2 2 2 0 ACT domain GCV_T PF01571.21 EPA05636.1 - 0.12 11.8 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain CARDB PF07705.11 EPA05637.1 - 0.026 14.8 0.1 0.06 13.6 0.1 1.6 1 0 0 1 1 1 0 CARDB Big_4 PF07532.11 EPA05637.1 - 0.046 13.5 0.2 0.11 12.3 0.2 1.7 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 4) APS_kinase PF01583.20 EPA05638.1 - 1.5e-50 171.2 0.0 1.8e-50 170.9 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 EPA05638.1 - 1.5e-06 28.4 0.0 2.2e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EPA05638.1 - 7.9e-05 23.2 0.0 0.00017 22.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EPA05638.1 - 0.00011 21.6 0.0 0.00036 19.9 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin AAA_17 PF13207.6 EPA05638.1 - 0.00081 19.8 0.0 0.0016 18.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EPA05638.1 - 0.001 18.6 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_28 PF13521.6 EPA05638.1 - 0.013 15.8 0.0 0.023 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain CPT PF07931.12 EPA05638.1 - 0.049 13.5 0.1 6.3 6.6 0.0 2.3 1 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Arf PF00025.21 EPA05638.1 - 0.12 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family Ammonium_transp PF00909.21 EPA05641.1 - 2.2e-113 378.9 29.1 2.5e-113 378.8 29.1 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3188 PF11384.8 EPA05641.1 - 0.079 12.7 0.1 0.079 12.7 0.1 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF3188) Fer4_12 PF13353.6 EPA05642.1 - 2.8e-13 50.3 0.7 1.3e-12 48.2 0.1 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EPA05642.1 - 7.3e-13 48.7 1.2 1.5e-12 47.7 0.3 2.0 1 1 1 2 2 2 1 4Fe-4S single cluster domain Radical_SAM PF04055.21 EPA05642.1 - 1.8e-08 35.0 0.0 2.5e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Usp PF00582.26 EPA05643.1 - 5.2e-28 98.3 0.0 6.5e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family DnaB_2 PF07261.11 EPA05643.1 - 0.06 13.1 0.2 0.11 12.3 0.2 1.3 1 0 0 1 1 1 0 Replication initiation and membrane attachment HSP20 PF00011.21 EPA05644.1 - 1.6e-06 28.2 4.4 3.1e-05 24.0 4.4 2.1 1 1 0 1 1 1 1 Hsp20/alpha crystallin family PIH1_CS PF18201.1 EPA05644.1 - 0.00013 22.3 0.2 0.00018 21.8 0.2 1.2 1 0 0 1 1 1 1 PIH1 CS-like domain ArsA_HSP20 PF17886.1 EPA05644.1 - 0.0013 18.3 0.1 0.0021 17.6 0.1 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Usp PF00582.26 EPA05646.1 - 6.3e-20 72.1 0.0 7e-20 72.0 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family ATP_bind_1 PF03029.17 EPA05647.1 - 4e-56 190.5 0.0 4.4e-56 190.4 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 EPA05647.1 - 0.0031 17.9 0.0 0.0045 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain MeaB PF03308.16 EPA05647.1 - 0.0039 16.2 0.0 0.0072 15.3 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2075 PF09848.9 EPA05647.1 - 0.0046 16.2 0.0 0.0094 15.2 0.0 1.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 EPA05647.1 - 0.0077 16.8 0.0 0.012 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain CLP1_P PF16575.5 EPA05647.1 - 0.0097 15.7 0.1 0.29 10.9 0.1 2.1 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CbiA PF01656.23 EPA05647.1 - 0.015 15.3 0.1 0.023 14.7 0.1 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain GTP_EFTU PF00009.27 EPA05647.1 - 0.017 14.7 0.2 1.3 8.6 0.2 3.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain SRP54 PF00448.22 EPA05647.1 - 0.025 14.2 0.1 1.5 8.4 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 EPA05647.1 - 0.065 13.3 0.1 0.89 9.7 0.1 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase NTPase_1 PF03266.15 EPA05647.1 - 0.079 12.9 0.1 1 9.3 0.0 2.2 2 0 0 2 2 2 0 NTPase AAA_24 PF13479.6 EPA05647.1 - 0.095 12.4 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EPA05647.1 - 0.095 13.0 0.1 0.16 12.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain Usp PF00582.26 EPA05648.1 - 7.6e-28 97.8 0.0 9.4e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family Phage_holin_2_1 PF04971.12 EPA05649.1 - 0.059 13.4 0.4 0.059 13.4 0.4 1.6 2 0 0 2 2 2 0 Bacteriophage P21 holin S ACT_7 PF13840.6 EPA05650.1 - 9.3e-07 28.6 0.1 1.8e-06 27.6 0.1 1.5 1 0 0 1 1 1 1 ACT domain SecD-TM1 PF13721.6 EPA05650.1 - 0.014 15.9 0.1 0.03 14.8 0.0 1.6 2 0 0 2 2 2 0 SecD export protein N-terminal TM region Pox_A3L PF05288.11 EPA05650.1 - 0.034 14.1 0.0 0.16 12.0 0.0 2.1 1 0 0 1 1 1 0 Poxvirus A3L Protein CBS PF00571.28 EPA05651.1 - 2.7e-25 88.6 3.9 1.1e-12 48.2 0.1 2.2 2 0 0 2 2 2 2 CBS domain CBS PF00571.28 EPA05652.1 - 3.1e-47 158.9 13.2 5.5e-14 52.4 0.6 4.1 4 0 0 4 4 4 4 CBS domain PhnJ PF06007.11 EPA05652.1 - 0.066 12.2 0.5 0.86 8.6 0.1 2.1 2 0 0 2 2 2 0 Phosphonate metabolism protein PhnJ TFIIB PF00382.19 EPA05653.1 - 1.4e-32 111.5 3.0 2.2e-15 56.4 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EPA05653.1 - 3.6e-06 26.4 0.2 7.8e-06 25.3 0.2 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_11 PF08279.12 EPA05653.1 - 1.5e-05 24.8 1.4 0.0069 16.3 0.1 2.6 2 0 0 2 2 2 2 HTH domain Cyclin_N PF00134.23 EPA05653.1 - 0.0016 18.2 0.2 0.67 9.7 0.0 2.2 1 1 1 2 2 2 2 Cyclin, N-terminal domain Herpes_UL51 PF04540.13 EPA05653.1 - 0.067 12.9 0.2 0.34 10.6 0.0 2.0 2 0 0 2 2 2 0 Herpesvirus UL51 protein DUF2543 PF10820.8 EPA05653.1 - 0.069 13.3 0.3 0.57 10.4 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2543) P-II PF00543.22 EPA05654.1 - 2.5e-12 47.3 0.5 3.2e-12 47.0 0.5 1.1 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DUF1059 PF06348.11 EPA05655.1 - 5.1e-08 33.0 0.1 7.7e-08 32.4 0.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1059) AAA_lid_9 PF17871.1 EPA05655.1 - 0.017 15.0 0.1 0.021 14.8 0.1 1.1 1 0 0 1 1 1 0 AAA lid domain adh_short_C2 PF13561.6 EPA05656.1 - 1.1e-72 244.4 0.0 1.3e-72 244.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EPA05656.1 - 4.3e-61 205.8 0.5 5e-61 205.6 0.5 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EPA05656.1 - 7e-08 32.6 0.0 1.1e-07 32.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EPA05656.1 - 0.014 14.8 0.4 0.019 14.4 0.0 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family ATP-synt_ab PF00006.25 EPA05656.1 - 0.028 14.1 0.0 0.056 13.1 0.0 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain 3HCDH_N PF02737.18 EPA05656.1 - 0.028 14.3 0.2 0.045 13.6 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 EPA05656.1 - 0.059 12.7 0.1 0.1 11.9 0.1 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain adh_short PF00106.25 EPA05657.1 - 8.2e-57 191.8 0.3 9.3e-57 191.6 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EPA05657.1 - 2.8e-39 135.1 0.0 3.3e-39 134.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EPA05657.1 - 4.5e-16 59.3 0.2 5.3e-16 59.0 0.2 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EPA05657.1 - 0.00051 19.5 0.0 0.0014 18.0 0.0 1.7 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 EPA05657.1 - 0.0014 17.8 0.1 0.0016 17.6 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EPA05657.1 - 0.0022 17.5 0.0 0.0029 17.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EPA05657.1 - 0.02 14.8 0.0 0.025 14.5 0.0 1.4 1 1 0 1 1 1 0 NAD(P)H-binding DFP PF04127.15 EPA05657.1 - 0.027 14.3 0.0 0.068 13.0 0.0 1.6 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein F420H2_quin_red PF04075.14 EPA05657.1 - 0.15 12.2 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 F420H(2)-dependent quinone reductase HMMR_N PF15905.5 EPA05658.1 - 3.6e-05 23.4 10.9 3.6e-05 23.4 10.9 1.4 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal Tropomyosin_1 PF12718.7 EPA05658.1 - 0.0002 21.5 16.2 0.00082 19.6 14.7 2.0 1 1 1 2 2 2 1 Tropomyosin like Spc7 PF08317.11 EPA05658.1 - 0.00047 19.1 10.5 0.00061 18.8 10.5 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF1664 PF07889.12 EPA05658.1 - 0.00082 19.4 6.5 0.00088 19.3 5.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1664) CREPT PF16566.5 EPA05658.1 - 0.002 18.3 3.1 0.0024 18.0 3.1 1.3 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour DUF3450 PF11932.8 EPA05658.1 - 0.0038 16.6 2.7 0.0059 15.9 2.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Laminin_II PF06009.12 EPA05658.1 - 0.0045 17.0 7.0 0.0065 16.5 7.0 1.3 1 0 0 1 1 1 1 Laminin Domain II Taxilin PF09728.9 EPA05658.1 - 0.0056 15.9 8.6 0.0056 15.9 8.6 1.5 1 1 1 2 2 2 1 Myosin-like coiled-coil protein AAA_13 PF13166.6 EPA05658.1 - 0.023 13.4 5.2 0.023 13.4 5.2 1.1 1 0 0 1 1 1 0 AAA domain Baculo_PEP_C PF04513.12 EPA05658.1 - 0.029 14.4 0.2 0.042 13.9 0.2 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF724 PF05266.14 EPA05658.1 - 0.039 13.8 7.8 0.06 13.2 7.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) THOC7 PF05615.13 EPA05658.1 - 0.059 13.7 5.6 0.46 10.8 5.6 2.0 1 1 1 2 2 2 0 Tho complex subunit 7 Fmp27_WPPW PF10359.9 EPA05658.1 - 0.059 12.2 5.0 0.072 11.9 4.5 1.3 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain FemAB PF02388.16 EPA05658.1 - 0.066 12.1 1.4 0.086 11.7 1.4 1.1 1 0 0 1 1 1 0 FemAB family GldM_N PF12081.8 EPA05658.1 - 0.069 13.2 5.4 0.048 13.8 3.1 1.8 1 1 1 2 2 2 0 GldM N-terminal domain Prefoldin PF02996.17 EPA05658.1 - 0.073 13.0 7.6 0.15 12.0 1.8 2.5 1 1 2 3 3 3 0 Prefoldin subunit Baculo_F PF12259.8 EPA05658.1 - 0.075 11.5 2.7 0.083 11.4 2.7 1.0 1 0 0 1 1 1 0 Baculovirus F protein DUF16 PF01519.16 EPA05658.1 - 0.099 13.1 10.7 0.29 11.6 4.7 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 Rx_N PF18052.1 EPA05658.1 - 0.12 12.7 3.5 0.19 12.0 3.5 1.5 1 0 0 1 1 1 0 Rx N-terminal domain NPV_P10 PF05531.12 EPA05658.1 - 0.14 12.7 6.8 0.76 10.3 1.6 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Prominin PF05478.11 EPA05658.1 - 0.15 10.0 3.0 0.17 9.8 3.0 1.0 1 0 0 1 1 1 0 Prominin Fib_alpha PF08702.10 EPA05658.1 - 0.22 11.7 7.1 0.6 10.3 6.9 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TMPIT PF07851.13 EPA05658.1 - 0.42 9.8 3.3 0.54 9.4 3.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein YabA PF06156.13 EPA05658.1 - 0.44 11.2 6.6 1.5 9.5 6.4 1.9 1 1 1 2 2 2 0 Initiation control protein YabA Spectrin PF00435.21 EPA05658.1 - 0.44 11.1 6.7 1.9 9.0 5.2 2.3 1 1 1 2 2 2 0 Spectrin repeat Syntaxin_2 PF14523.6 EPA05658.1 - 0.48 10.8 7.4 26 5.3 7.4 2.5 1 1 0 1 1 1 0 Syntaxin-like protein Atg14 PF10186.9 EPA05658.1 - 0.49 9.4 7.1 0.59 9.2 7.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Mei5 PF10376.9 EPA05658.1 - 0.49 10.2 12.3 3.8 7.3 12.3 2.0 1 1 0 1 1 1 0 Double-strand recombination repair protein DUF948 PF06103.11 EPA05658.1 - 0.84 9.9 2.5 7.2 6.9 2.5 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) UPF0242 PF06785.11 EPA05658.1 - 0.94 9.6 9.6 1.3 9.0 9.6 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FlaC_arch PF05377.11 EPA05658.1 - 0.94 9.9 12.2 1.5 9.2 4.0 2.9 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) FAM76 PF16046.5 EPA05658.1 - 1.3 8.3 7.6 1.5 8.1 7.6 1.1 1 0 0 1 1 1 0 FAM76 protein zf-C4H2 PF10146.9 EPA05658.1 - 3.5 7.9 8.2 5.5 7.2 8.2 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein Nas2_N PF18265.1 EPA05658.1 - 5.2 7.1 8.4 5.6 7.0 0.2 3.4 1 1 1 3 3 3 0 Nas2 N_terminal domain XhlA PF10779.9 EPA05658.1 - 9.4 6.5 12.8 4.7 7.5 4.7 2.6 1 1 2 3 3 3 0 Haemolysin XhlA PAC2 PF09754.9 EPA05659.1 - 5.8e-32 111.4 0.0 6.6e-32 111.3 0.0 1.0 1 0 0 1 1 1 1 PAC2 family CRPA PF05745.11 EPA05660.1 - 0.053 13.5 2.7 0.059 13.4 2.7 1.1 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Saf_2TM PF18303.1 EPA05660.1 - 7.2 6.2 8.4 1e+02 2.4 8.4 2.0 1 1 0 1 1 1 0 SAVED-fused 2TM effector domain Holin_BlyA PF05102.12 EPA05660.1 - 7.9 6.5 11.7 3.4 7.7 2.0 2.1 1 1 1 2 2 2 0 holin, BlyA family LPG_synthase_TM PF03706.13 EPA05661.1 - 7.8e-23 81.5 15.5 1e-22 81.0 15.5 1.2 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region SIS PF01380.22 EPA05661.1 - 0.038 13.8 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 SIS domain Inositol_P PF00459.25 EPA05662.1 - 3.4e-48 164.5 0.1 3.8e-48 164.3 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.20 EPA05662.1 - 0.0096 15.4 0.1 0.017 14.6 0.1 1.4 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain MTBP_N PF14918.6 EPA05662.1 - 0.05 13.1 0.0 0.17 11.3 0.0 1.8 2 0 0 2 2 2 0 MDM2-binding GTP_cyclohydroI PF01227.22 EPA05663.1 - 1.4e-64 216.9 0.1 1.6e-64 216.7 0.1 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EPA05663.1 - 0.013 15.7 0.0 0.025 14.7 0.0 1.5 1 0 0 1 1 1 0 QueF-like protein OST-HTH PF12872.7 EPA05663.1 - 0.035 13.9 0.1 1.5 8.7 0.0 2.3 2 0 0 2 2 2 0 OST-HTH/LOTUS domain Pyr_redox_2 PF07992.14 EPA05664.1 - 1.5e-49 168.8 0.0 1.9e-49 168.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EPA05664.1 - 6.7e-17 61.8 2.0 4.9e-11 43.0 0.7 3.5 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EPA05664.1 - 2.7e-08 33.8 0.2 1.5 8.3 0.0 4.1 4 0 0 4 4 4 4 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EPA05664.1 - 0.003 16.9 0.0 0.1 11.8 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EPA05664.1 - 0.0046 16.1 0.1 1.8 7.6 0.0 2.5 2 0 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EPA05664.1 - 0.032 14.2 0.1 8.4 6.4 0.1 3.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 EPA05664.1 - 0.043 13.0 0.0 0.55 9.3 0.0 2.6 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 EPA05664.1 - 0.063 12.1 0.0 1.4 7.7 0.0 2.4 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_8 PF13450.6 EPA05664.1 - 0.11 12.8 0.1 13 6.1 0.0 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain T4-gp15_tss PF16724.5 EPA05664.1 - 0.11 12.3 0.1 0.29 10.8 0.0 1.7 2 0 0 2 2 2 0 T4-like virus Myoviridae tail sheath stabiliser Usp PF00582.26 EPA05665.1 - 8.3e-31 107.4 0.0 1e-30 107.1 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family PRORP PF16953.5 EPA05665.1 - 0.019 14.5 0.0 0.021 14.3 0.0 1.1 1 0 0 1 1 1 0 Protein-only RNase P DLIC PF05783.11 EPA05665.1 - 0.054 12.3 0.5 0.069 12.0 0.1 1.3 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) P-II PF00543.22 EPA05667.1 - 1.9e-08 34.8 0.9 3.5e-08 34.0 0.9 1.4 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II HTH_45 PF14947.6 EPA05668.1 - 1.5e-07 31.3 0.0 1.8e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix MarR_2 PF12802.7 EPA05668.1 - 8.6e-06 25.6 0.0 1.2e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 EPA05668.1 - 0.0002 21.8 0.0 0.00027 21.4 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain DUF4364 PF14277.6 EPA05668.1 - 0.0029 17.4 0.0 0.0036 17.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) Mrr_N PF14338.6 EPA05668.1 - 0.0057 16.7 0.0 0.027 14.6 0.0 1.9 1 1 1 2 2 2 1 Mrr N-terminal domain HTH_20 PF12840.7 EPA05668.1 - 0.0098 15.9 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain DUF1495 PF07381.11 EPA05668.1 - 0.019 14.7 0.0 0.035 13.9 0.0 1.5 1 1 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) RNA_pol_Rpc34 PF05158.12 EPA05668.1 - 0.024 14.0 0.0 0.03 13.7 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit TrmB PF01978.19 EPA05668.1 - 0.03 14.2 0.1 0.051 13.5 0.1 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF2250 PF10007.9 EPA05668.1 - 0.06 13.5 0.0 0.077 13.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) DDRGK PF09756.9 EPA05668.1 - 0.067 12.8 0.1 0.075 12.6 0.1 1.0 1 0 0 1 1 1 0 DDRGK domain Rrf2 PF02082.20 EPA05668.1 - 0.13 12.6 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator AAA PF00004.29 EPA05669.1 - 7.1e-100 330.6 0.0 9.3e-51 171.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EPA05669.1 - 2.1e-27 94.6 0.9 9.3e-13 47.8 0.2 2.7 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EPA05669.1 - 2e-23 82.3 0.0 5.4e-23 81.0 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 EPA05669.1 - 3.1e-16 60.0 0.1 3.8e-07 30.4 0.0 2.9 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EPA05669.1 - 2.3e-14 53.4 0.0 1.3e-07 31.5 0.0 2.9 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EPA05669.1 - 3.5e-14 53.5 0.0 6e-06 26.7 0.0 3.4 2 1 0 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 EPA05669.1 - 5.1e-12 46.0 2.5 0.00026 21.0 0.0 4.0 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EPA05669.1 - 2.8e-10 40.6 1.9 0.0051 17.1 0.0 4.3 2 2 2 4 4 4 2 AAA domain TIP49 PF06068.13 EPA05669.1 - 3.2e-10 39.7 0.3 0.00079 18.7 0.0 2.8 3 0 0 3 3 2 2 TIP49 P-loop domain AAA_33 PF13671.6 EPA05669.1 - 6.2e-10 39.4 0.0 0.00018 21.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EPA05669.1 - 8.1e-10 38.8 0.0 0.00041 20.4 0.0 3.4 3 0 0 3 3 3 2 AAA domain CDC48_2 PF02933.17 EPA05669.1 - 1.2e-09 37.8 0.6 3.2e-09 36.4 0.6 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 Mg_chelatase PF01078.21 EPA05669.1 - 1.5e-08 34.3 0.3 0.0018 17.7 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EPA05669.1 - 6.8e-08 32.4 0.1 0.014 15.2 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 EPA05669.1 - 1.5e-07 32.0 0.1 0.0082 16.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EPA05669.1 - 5.7e-07 29.4 0.0 0.01 15.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EPA05669.1 - 6e-07 29.2 1.2 0.11 12.0 0.0 3.5 2 1 0 3 3 3 2 AAA domain Sigma54_activat PF00158.26 EPA05669.1 - 1.2e-06 28.3 0.3 0.19 11.4 0.0 4.1 2 2 0 2 2 2 2 Sigma-54 interaction domain RNA_helicase PF00910.22 EPA05669.1 - 1.5e-06 28.6 0.0 0.068 13.6 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Zeta_toxin PF06414.12 EPA05669.1 - 1.7e-06 27.5 0.2 0.012 14.9 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_7 PF12775.7 EPA05669.1 - 2e-06 27.4 0.1 0.058 12.9 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_28 PF13521.6 EPA05669.1 - 2.9e-06 27.6 0.1 0.099 12.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 EPA05669.1 - 6.1e-06 26.8 0.1 0.21 12.1 0.0 3.0 2 0 0 2 2 2 2 ABC transporter AAA_3 PF07726.11 EPA05669.1 - 1.2e-05 25.1 0.0 0.034 14.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EPA05669.1 - 3.3e-05 23.8 0.0 0.085 12.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.13 EPA05669.1 - 4.2e-05 22.8 0.0 0.27 10.4 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF815) TsaE PF02367.17 EPA05669.1 - 5.3e-05 23.2 0.2 0.49 10.4 0.1 2.7 2 1 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 EPA05669.1 - 6.7e-05 22.1 0.2 0.16 11.1 0.1 2.4 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_30 PF13604.6 EPA05669.1 - 8.3e-05 22.4 0.3 0.17 11.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EPA05669.1 - 0.00011 22.2 1.1 0.6 10.0 0.1 3.7 4 0 0 4 4 3 2 NACHT domain PhoH PF02562.16 EPA05669.1 - 0.00015 21.3 0.4 0.48 9.8 0.1 2.7 2 0 0 2 2 2 2 PhoH-like protein DUF2075 PF09848.9 EPA05669.1 - 0.00046 19.5 0.0 0.48 9.6 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EPA05669.1 - 0.0011 19.3 2.9 1.4 9.3 0.0 3.7 4 0 0 4 4 3 1 AAA domain Sigma54_activ_2 PF14532.6 EPA05669.1 - 0.0014 18.7 0.0 2.2 8.4 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain TniB PF05621.11 EPA05669.1 - 0.0017 17.8 0.0 0.65 9.4 0.0 3.1 3 0 0 3 3 3 1 Bacterial TniB protein Guanylate_kin PF00625.21 EPA05669.1 - 0.0017 18.1 0.5 5.6 6.6 0.0 4.2 3 1 1 4 4 4 0 Guanylate kinase UFD1 PF03152.14 EPA05669.1 - 0.0018 17.8 0.1 0.0034 16.9 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 AFG1_ATPase PF03969.16 EPA05669.1 - 0.0023 16.9 0.0 0.78 8.6 0.0 2.4 2 0 0 2 2 2 1 AFG1-like ATPase ResIII PF04851.15 EPA05669.1 - 0.0039 17.2 0.1 0.75 9.8 0.0 2.9 3 0 0 3 3 2 1 Type III restriction enzyme, res subunit CPT PF07931.12 EPA05669.1 - 0.0043 16.9 0.1 0.15 11.9 0.0 2.6 2 1 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.6 EPA05669.1 - 0.0049 17.3 0.0 3.5 8.1 0.0 2.9 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 EPA05669.1 - 0.0059 16.5 0.0 0.44 10.4 0.0 2.7 2 1 0 2 2 2 1 Bacterial dnaA protein NB-ARC PF00931.22 EPA05669.1 - 0.0096 15.1 0.2 4.1 6.5 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.15 EPA05669.1 - 0.01 15.7 2.8 4.9 7.0 0.0 4.1 3 1 1 4 4 3 0 NTPase T2SSE PF00437.20 EPA05669.1 - 0.019 14.1 0.0 2.2 7.3 0.0 2.7 2 0 0 2 2 2 0 Type II/IV secretion system protein Cytidylate_kin PF02224.18 EPA05669.1 - 0.02 14.6 1.6 5.3 6.7 0.0 3.1 3 0 0 3 3 3 0 Cytidylate kinase Viral_helicase1 PF01443.18 EPA05669.1 - 0.025 14.3 0.0 0.26 11.0 0.0 2.5 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.6 EPA05669.1 - 0.028 14.1 0.0 7.4 6.4 0.0 2.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain IPT PF01745.16 EPA05669.1 - 0.033 13.6 0.5 2 7.7 0.1 2.5 2 0 0 2 2 2 0 Isopentenyl transferase PIF1 PF05970.14 EPA05669.1 - 0.042 13.0 0.0 4.7 6.3 0.0 2.9 2 0 0 2 2 2 0 PIF1-like helicase ATPase PF06745.13 EPA05669.1 - 0.055 12.8 10.7 0.54 9.6 0.1 4.2 4 1 0 5 5 4 0 KaiC ATPase_2 PF01637.18 EPA05669.1 - 0.065 13.1 2.6 0.67 9.8 0.1 3.3 3 2 1 4 4 3 0 ATPase domain predominantly from Archaea Torsin PF06309.11 EPA05669.1 - 0.066 13.3 0.1 2.5 8.2 0.0 2.6 2 0 0 2 2 2 0 Torsin Rad17 PF03215.15 EPA05669.1 - 0.075 13.0 0.3 11 5.9 0.0 2.9 2 2 1 3 3 3 0 Rad17 P-loop domain Vps4_C PF09336.10 EPA05669.1 - 0.082 12.9 4.5 0.76 9.8 0.1 3.3 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain Hydin_ADK PF17213.3 EPA05669.1 - 0.24 11.7 1.2 1 9.6 0.1 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain AAA_23 PF13476.6 EPA05669.1 - 2.8 8.4 7.4 2.6 8.5 0.2 3.6 2 2 0 2 2 2 0 AAA domain CopG_antitoxin PF12441.8 EPA05670.1 - 0.00029 21.3 0.6 0.0014 19.1 0.2 2.2 2 0 0 2 2 2 1 CopG antitoxin of type II toxin-antitoxin system DUF4363 PF14276.6 EPA05671.1 - 0.034 14.3 0.3 0.038 14.1 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) Arm-DNA-bind_2 PF12167.8 EPA05671.1 - 0.039 13.9 0.1 0.05 13.5 0.1 1.2 1 0 0 1 1 1 0 Arm DNA-binding domain GLE1 PF07817.13 EPA05671.1 - 0.16 11.1 1.4 0.17 11.1 1.4 1.0 1 0 0 1 1 1 0 GLE1-like protein Snf7 PF03357.21 EPA05672.1 - 3.1e-06 26.9 4.9 5.2e-06 26.2 4.9 1.4 1 1 0 1 1 1 1 Snf7 TMF_DNA_bd PF12329.8 EPA05672.1 - 0.033 14.2 0.9 0.033 14.2 0.9 2.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding RHSP PF07999.11 EPA05672.1 - 0.038 12.8 0.1 0.044 12.6 0.1 1.1 1 0 0 1 1 1 0 Retrotransposon hot spot protein RVT_N PF13655.6 EPA05672.1 - 0.057 13.7 1.2 0.39 11.0 0.2 2.5 1 1 1 2 2 2 0 N-terminal domain of reverse transcriptase Baculo_PEP_C PF04513.12 EPA05672.1 - 0.067 13.2 4.6 0.87 9.6 4.6 2.2 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus BRE1 PF08647.11 EPA05672.1 - 0.15 12.1 0.5 0.15 12.1 0.5 2.5 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase V-ATPase_H_C PF11698.8 EPA05672.1 - 0.18 11.9 1.4 2.6 8.2 1.4 2.2 1 1 0 1 1 1 0 V-ATPase subunit H GPS2_interact PF15784.5 EPA05672.1 - 0.19 12.2 2.1 2.9 8.4 1.8 2.3 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain GlcNAc_2-epim PF07221.11 EPA05673.1 - 0.019 14.2 4.0 0.026 13.8 0.8 2.0 2 0 0 2 2 2 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) DUF1957 PF09210.11 EPA05673.1 - 0.042 14.2 3.5 3.8 8.0 0.3 3.0 2 2 1 3 3 3 0 Domain of unknown function (DUF1957) DDE_Tnp_IS66 PF03050.14 EPA05673.1 - 0.32 10.4 11.6 0.42 10.0 2.1 2.3 2 0 0 2 2 2 0 Transposase IS66 family ERp29 PF07749.12 EPA05673.1 - 0.97 10.4 10.9 1.8 9.5 1.9 3.0 2 2 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain DUF4695 PF15766.5 EPA05673.1 - 1.4 9.2 6.5 2 8.7 0.2 2.6 2 2 0 2 2 2 0 Domain of unknown function (DUF4695) YtxH PF12732.7 EPA05673.1 - 5.4 7.6 10.6 2.4 8.8 0.6 3.6 1 1 1 2 2 2 0 YtxH-like protein Prp18 PF02840.15 EPA05673.1 - 7.9 6.5 13.9 1.4 9.0 1.5 2.7 1 1 2 3 3 3 0 Prp18 domain Wbp11 PF09429.10 EPA05673.1 - 7.9 7.0 18.7 0.72 10.3 0.2 3.9 2 2 2 4 4 4 0 WW domain binding protein 11 QueC PF06508.13 EPA05675.1 - 1.1e-47 162.3 0.0 1.2e-47 162.1 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Arginosuc_synth PF00764.19 EPA05675.1 - 0.00015 21.2 0.0 0.00018 20.9 0.0 1.1 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.21 EPA05675.1 - 0.00044 20.0 0.0 0.0006 19.6 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.17 EPA05675.1 - 0.0071 15.5 0.0 0.0092 15.1 0.0 1.2 1 0 0 1 1 1 1 NAD synthase ATP_bind_3 PF01171.20 EPA05675.1 - 0.05 13.4 0.0 0.082 12.7 0.0 1.4 1 0 0 1 1 1 0 PP-loop family TFIIB PF00382.19 EPA05677.1 - 7e-33 112.5 6.2 8.5e-16 57.8 0.4 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EPA05677.1 - 8.1e-10 38.1 0.4 1.4e-09 37.3 0.4 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 EPA05677.1 - 0.0067 16.2 0.3 0.075 12.8 0.1 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Sigma70_r4 PF04545.16 EPA05677.1 - 0.0083 15.6 0.0 0.024 14.2 0.0 1.8 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_11 PF08279.12 EPA05677.1 - 0.0086 16.0 0.2 0.33 10.9 0.0 2.8 3 0 0 3 3 3 1 HTH domain RPA_interact_C PF14768.6 EPA05677.1 - 0.016 15.8 0.0 0.046 14.3 0.0 1.9 1 0 0 1 1 1 0 Replication protein A interacting C-terminal HTH_AsnC-type PF13404.6 EPA05677.1 - 0.016 15.0 0.0 0.19 11.6 0.0 2.3 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain Sigma70_r4_2 PF08281.12 EPA05677.1 - 0.021 14.5 0.2 0.28 10.9 0.0 2.4 2 0 0 2 2 2 0 Sigma-70, region 4 zinc_ribbon_2 PF13240.6 EPA05677.1 - 0.026 14.2 1.9 0.068 12.9 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-FPG_IleRS PF06827.14 EPA05677.1 - 0.032 14.1 0.3 0.5 10.3 0.1 2.5 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Phage_terminase PF10668.9 EPA05677.1 - 0.055 13.5 0.2 1.4 9.0 0.0 2.8 3 0 0 3 3 3 0 Phage terminase small subunit Baculo_ME53 PF06061.11 EPA05677.1 - 0.1 11.8 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 Baculoviridae ME53 RB_B PF01857.20 EPA05677.1 - 0.11 12.6 0.1 0.21 11.6 0.1 1.5 1 1 0 1 1 1 0 Retinoblastoma-associated protein B domain zf-piccolo PF05715.13 EPA05677.1 - 0.17 12.0 1.4 0.49 10.6 1.4 1.8 1 1 0 1 1 1 0 Piccolo Zn-finger Cyclin_C PF02984.19 EPA05677.1 - 0.2 11.8 0.3 8.2 6.5 0.0 2.3 1 1 0 2 2 2 0 Cyclin, C-terminal domain HTH_23 PF13384.6 EPA05677.1 - 0.22 11.4 1.8 0.54 10.1 0.0 2.5 3 0 0 3 3 2 0 Homeodomain-like domain Auto_anti-p27 PF06677.12 EPA05677.1 - 0.24 11.6 1.4 0.44 10.7 1.4 1.4 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) A2L_zn_ribbon PF08792.10 EPA05677.1 - 0.26 11.0 1.1 0.55 10.0 1.1 1.5 1 0 0 1 1 1 0 A2L zinc ribbon domain zf-ribbon_3 PF13248.6 EPA05677.1 - 0.27 10.7 1.4 1.4 8.5 1.4 2.1 1 1 0 1 1 1 0 zinc-ribbon domain zf-CCHC_5 PF14787.6 EPA05677.1 - 1.7 8.4 5.5 0.76 9.5 0.3 2.6 3 0 0 3 3 2 0 GAG-polyprotein viral zinc-finger GHMP_kinases_N PF00288.26 EPA05678.1 - 1.6e-13 50.7 1.5 3.6e-13 49.5 1.5 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EPA05678.1 - 2.5e-08 34.2 0.0 5.2e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal IL5 PF02025.15 EPA05680.1 - 0.0019 18.5 0.1 0.0022 18.2 0.1 1.1 1 0 0 1 1 1 1 Interleukin 5 Alginate_exp PF13372.6 EPA05680.1 - 0.0072 15.1 0.0 0.0083 14.9 0.0 1.0 1 0 0 1 1 1 1 Alginate export RE_Alw26IDE PF09665.10 EPA05680.1 - 0.016 14.4 0.0 0.017 14.3 0.0 1.0 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) Pneumovirus_M2 PF06436.11 EPA05680.1 - 0.018 14.5 0.8 0.026 14.0 0.8 1.2 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) S_100 PF01023.19 EPA05680.1 - 0.019 14.7 1.8 2.9 7.7 0.2 2.3 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain HTH_micro PF17007.5 EPA05682.1 - 0.00046 19.1 0.2 0.00064 18.7 0.2 1.2 1 0 0 1 1 1 1 HTH-like HTH_24 PF13412.6 EPA05682.1 - 0.0056 16.2 0.0 0.032 13.8 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding CRCB PF02537.15 EPA05683.1 - 3.4e-19 69.0 4.5 4e-19 68.7 4.5 1.1 1 0 0 1 1 1 1 CrcB-like protein, Camphor Resistance (CrcB) DUF2104 PF09877.9 EPA05683.1 - 0.0032 17.7 1.4 0.0045 17.2 0.9 1.5 1 1 0 1 1 1 1 Predicted membrane protein (DUF2104) CBS PF00571.28 EPA05684.1 - 2e-26 92.2 1.9 7.6e-13 48.7 0.1 2.1 2 0 0 2 2 2 2 CBS domain HSP20 PF00011.21 EPA05685.1 - 1.9e-13 50.4 0.0 2.7e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EPA05685.1 - 7.3e-10 38.3 0.0 9.6e-10 37.9 0.0 1.2 1 0 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 EPA05685.1 - 0.00066 20.6 0.9 0.00066 20.6 0.9 1.5 2 0 0 2 2 2 1 CS domain PIH1_CS PF18201.1 EPA05685.1 - 0.028 14.8 0.0 0.058 13.8 0.0 1.6 1 1 0 1 1 1 0 PIH1 CS-like domain Ceramidase PF05875.12 EPA05686.1 - 0.042 13.3 0.0 0.05 13.0 0.0 1.0 1 0 0 1 1 1 0 Ceramidase SKG6 PF08693.10 EPA05686.1 - 0.045 13.2 0.7 0.045 13.2 0.7 2.0 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Phage_holin_2_4 PF16082.5 EPA05686.1 - 1.5 8.6 6.6 1.3 8.8 1.0 2.0 1 1 1 2 2 2 0 Bacteriophage holin family, superfamily II-like Saf_2TM PF18303.1 EPA05686.1 - 7 6.2 7.0 12 5.5 0.8 2.0 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain TFIIB PF00382.19 EPA05687.1 - 3.4e-33 113.5 1.6 8.8e-16 57.7 0.4 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EPA05687.1 - 1.1e-07 31.3 0.8 2e-07 30.4 0.8 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Sigma70_r4 PF04545.16 EPA05687.1 - 0.00048 19.6 0.0 0.048 13.2 0.0 2.5 2 0 0 2 2 2 1 Sigma-70, region 4 Cyclin_N PF00134.23 EPA05687.1 - 0.0013 18.4 0.0 0.019 14.7 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain A2L_zn_ribbon PF08792.10 EPA05687.1 - 0.0022 17.6 0.6 0.0042 16.8 0.6 1.5 1 0 0 1 1 1 1 A2L zinc ribbon domain Cyclin_C PF02984.19 EPA05687.1 - 0.0045 17.1 0.0 3.6 7.7 0.0 2.3 2 0 0 2 2 2 2 Cyclin, C-terminal domain NOB1_Zn_bind PF08772.11 EPA05687.1 - 0.047 13.8 0.5 0.12 12.5 0.5 1.6 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Sigma70_r4_2 PF08281.12 EPA05687.1 - 0.074 12.7 0.0 0.18 11.5 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 Ribosomal_L37e PF01907.19 EPA05687.1 - 0.077 13.2 0.3 0.2 11.8 0.3 1.8 1 0 0 1 1 1 0 Ribosomal protein L37e HTH_11 PF08279.12 EPA05687.1 - 0.082 12.9 1.5 1.5 8.8 0.0 2.8 3 0 0 3 3 3 0 HTH domain Evr1_Alr PF04777.13 EPA05689.1 - 0.012 16.1 0.1 0.013 15.9 0.1 1.1 1 0 0 1 1 1 0 Erv1 / Alr family dCMP_cyt_deam_1 PF00383.23 EPA05689.1 - 0.069 13.0 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region Pox_vIL-18BP PF05566.12 EPA05689.1 - 0.14 12.4 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 Orthopoxvirus interleukin 18 binding protein CBS PF00571.28 EPA05690.1 - 4.3e-25 87.9 2.1 1.6e-07 31.6 0.1 4.4 4 0 0 4 4 4 4 CBS domain NLE PF08154.12 EPA05690.1 - 0.015 15.8 0.8 5.2 7.7 0.0 3.1 3 0 0 3 3 3 0 NLE (NUC135) domain zinc_ribbon_13 PF09855.9 EPA05691.1 - 0.011 15.9 1.6 0.027 14.6 1.6 1.6 1 1 0 1 1 1 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Lar_restr_allev PF14354.6 EPA05691.1 - 0.02 15.3 0.1 0.023 15.1 0.1 1.2 1 0 0 1 1 1 0 Restriction alleviation protein Lar DUF2225 PF09986.9 EPA05691.1 - 0.023 14.4 1.3 0.054 13.2 1.3 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) TF_Zn_Ribbon PF08271.12 EPA05691.1 - 0.063 12.8 0.3 7.5 6.2 0.0 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding HypA PF01155.19 EPA05691.1 - 0.14 12.2 1.1 1.8 8.6 0.2 2.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA P3A PF08727.11 EPA05692.1 - 0.019 14.3 0.4 0.047 13.1 0.2 1.8 1 1 1 2 2 2 0 Poliovirus 3A protein like ILVD_EDD PF00920.21 EPA05693.1 - 7.4e-160 533.0 2.8 8.4e-160 532.8 2.8 1.0 1 0 0 1 1 1 1 Dehydratase family Ribosomal_S24e PF01282.19 EPA05693.1 - 0.014 15.4 0.4 8.3 6.4 0.1 2.8 3 0 0 3 3 3 0 Ribosomal protein S24e T2SSF PF00482.23 EPA05694.1 - 0.0057 16.6 0.6 0.0057 16.6 0.6 1.9 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein F Putative_PNPOx PF01243.20 EPA05695.1 - 6.9e-12 45.4 0.0 8.6e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 EPA05695.1 - 6e-07 29.5 0.0 7.3e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF447 PF04289.12 EPA05695.1 - 0.028 14.2 0.0 0.028 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF447) Rotamase_3 PF13616.6 EPA05697.1 - 8.9e-26 90.7 0.2 1.5e-25 90.0 0.2 1.3 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 EPA05697.1 - 5.2e-23 81.8 0.1 6.2e-23 81.6 0.1 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 EPA05697.1 - 1.7e-07 32.1 0.0 2e-07 31.8 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain NTPase_I-T PF01931.18 EPA05697.1 - 0.0041 16.9 0.0 0.0054 16.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF84 PapD_C PF02753.17 EPA05697.1 - 0.036 14.4 0.0 0.048 14.0 0.0 1.2 1 0 0 1 1 1 0 Pili assembly chaperone PapD, C-terminal domain DUF2407_C PF13373.6 EPA05698.1 - 0.029 14.5 0.0 0.031 14.4 0.0 1.1 1 0 0 1 1 1 0 DUF2407 C-terminal domain TrmB PF01978.19 EPA05699.1 - 3.8e-14 52.3 0.1 7.9e-14 51.3 0.1 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 EPA05699.1 - 2.8e-05 23.9 0.0 5.4e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 EPA05699.1 - 0.0013 18.8 0.0 0.0028 17.7 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 EPA05699.1 - 0.0029 17.5 0.0 0.0072 16.2 0.0 1.7 1 0 0 1 1 1 1 MarR family RisS_PPD PF16524.5 EPA05699.1 - 0.016 15.5 0.0 0.033 14.4 0.0 1.6 1 0 0 1 1 1 0 Periplasmic domain of Sensor histidine kinase RisS HTH_11 PF08279.12 EPA05699.1 - 0.069 13.1 0.6 0.37 10.8 0.1 2.4 2 0 0 2 2 2 0 HTH domain T2SSF PF00482.23 EPA05700.1 - 5.3e-18 65.2 0.3 1.6e-17 63.7 0.3 1.9 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein F MtrG PF04210.13 EPA05700.1 - 0.0074 16.1 2.1 0.03 14.2 0.3 2.7 3 0 0 3 3 3 1 Tetrahydromethanopterin S-methyltransferase, subunit G Spore_III_AB PF09548.10 EPA05700.1 - 0.023 14.8 1.5 0.064 13.4 0.0 2.1 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Rab5ip PF07019.12 EPA05700.1 - 6.8 7.4 11.5 33 5.2 0.1 3.5 3 0 0 3 3 3 0 Rab5-interacting protein (Rab5ip) DUF2203 PF09969.9 EPA05701.1 - 9.4e-36 123.2 0.1 1.1e-35 123.1 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2203) GCR1_C PF12550.8 EPA05701.1 - 0.088 13.1 1.1 0.13 12.6 0.1 1.8 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes Helicase_C PF00271.31 EPA05702.1 - 6.8e-24 84.4 0.1 2e-23 82.9 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EPA05702.1 - 8.9e-20 71.4 0.0 2.7e-19 69.8 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EPA05702.1 - 5.9e-18 65.2 0.1 3.3e-17 62.8 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Flavi_DEAD PF07652.14 EPA05702.1 - 0.0034 17.4 0.0 0.0078 16.2 0.0 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain Helicase_C_2 PF13307.6 EPA05702.1 - 0.03 14.5 0.0 0.7 10.0 0.0 2.4 2 0 0 2 2 2 0 Helicase C-terminal domain DUF3638 PF12340.8 EPA05702.1 - 0.067 12.5 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) DUF2007 PF09413.10 EPA05702.1 - 0.12 12.5 0.0 1.1 9.4 0.0 2.5 2 0 0 2 2 2 0 Putative prokaryotic signal transducing protein MG2 PF01835.19 EPA05703.1 - 0.021 15.3 0.0 0.095 13.2 0.0 2.2 1 0 0 1 1 1 0 MG2 domain BNR PF02012.20 EPA05703.1 - 3.3 8.1 11.5 3.1 8.2 0.4 4.4 4 0 0 4 4 4 0 BNR/Asp-box repeat Laminin_G_3 PF13385.6 EPA05704.1 - 2.4e-11 44.0 0.4 1e-09 38.7 0.4 2.6 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF2802 PF10975.8 EPA05704.1 - 0.11 12.6 2.4 15 5.8 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2802) DUF2099 PF09872.9 EPA05704.1 - 0.12 11.6 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2099) Tn7_TnsC_Int PF11426.8 EPA05704.1 - 0.2 11.9 5.2 10 6.4 0.3 3.5 4 0 0 4 4 4 0 Tn7 transposition regulator TnsC CBS PF00571.28 EPA05705.1 - 1.3e-16 60.7 0.4 2.8e-07 30.9 0.0 2.1 2 0 0 2 2 2 2 CBS domain NPR1_like_C PF12313.8 EPA05705.1 - 0.021 14.4 0.1 0.034 13.7 0.1 1.4 1 1 0 1 1 1 0 NPR1/NIM1 like defence protein C terminal FKBP_N PF01346.18 EPA05705.1 - 0.095 13.7 0.2 0.78 10.7 0.2 2.0 1 1 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Nup188_C PF18378.1 EPA05706.1 - 0.047 12.5 0.0 0.047 12.5 0.0 1.0 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain TFB6 PF17110.5 EPA05706.1 - 0.077 12.7 0.0 0.09 12.5 0.0 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DNase-RNase PF02577.14 EPA05708.1 - 1.5e-07 31.1 0.0 1.5e-07 31.1 0.0 1.0 1 0 0 1 1 1 1 Bifunctional nuclease CbtB PF09489.10 EPA05709.1 - 6e-13 48.7 2.3 8.6e-13 48.2 2.3 1.3 1 0 0 1 1 1 1 Probable cobalt transporter subunit (CbtB) HIT PF01230.23 EPA05710.1 - 2.5e-23 82.7 1.7 3.2e-23 82.3 1.7 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EPA05710.1 - 4.3e-11 43.3 0.6 5.4e-11 43.0 0.6 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EPA05710.1 - 0.07 13.0 1.0 0.11 12.4 1.0 1.3 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 SMC_hinge PF06470.13 EPA05710.1 - 0.11 12.8 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain MarB PF13999.6 EPA05710.1 - 0.13 12.1 0.5 0.31 10.9 0.1 1.8 2 1 0 2 2 2 0 MarB protein eRF1_3 PF03465.15 EPA05711.1 - 1.6e-18 67.2 0.1 2.8e-18 66.5 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 EPA05711.1 - 2.4e-11 44.1 0.0 1.2e-10 41.8 0.0 2.2 3 0 0 3 3 3 1 eRF1 domain 2 eRF1_1 PF03463.15 EPA05712.1 - 4.8e-10 39.5 0.0 6.7e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 eRF1 domain 1 RNA_pol_Rpb1_6 PF04992.14 EPA05712.1 - 0.16 11.8 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 6 Thioredoxin_4 PF13462.6 EPA05713.1 - 1.3e-32 113.3 0.0 1.6e-32 113.0 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 EPA05713.1 - 8.8e-16 58.3 0.0 9.3e-15 54.9 0.0 1.9 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 EPA05713.1 - 1.8e-09 38.0 0.1 3e-09 37.3 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_5 PF13743.6 EPA05713.1 - 2.2e-05 24.2 0.0 2.8e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin PF00085.20 EPA05713.1 - 0.087 12.8 0.1 0.34 10.9 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin HTH_20 PF12840.7 EPA05714.1 - 5e-07 29.7 0.0 7.3e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 EPA05714.1 - 1.4e-06 28.1 0.6 2.6e-06 27.2 0.4 1.6 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB TFIIE_alpha PF02002.17 EPA05714.1 - 2.1e-05 24.3 0.7 2.5e-05 24.1 0.7 1.1 1 0 0 1 1 1 1 TFIIE alpha subunit HTH_5 PF01022.20 EPA05714.1 - 0.00022 21.0 0.8 0.00045 20.0 0.5 1.7 2 1 0 2 2 2 1 Bacterial regulatory protein, arsR family DUF742 PF05331.11 EPA05714.1 - 0.0015 18.3 0.0 0.0019 18.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF742) HTH_IclR PF09339.10 EPA05714.1 - 0.0025 17.6 0.0 0.0039 17.0 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_11 PF08279.12 EPA05714.1 - 0.0036 17.2 0.9 0.0067 16.3 0.9 1.5 1 0 0 1 1 1 1 HTH domain Mga PF05043.13 EPA05714.1 - 0.013 16.0 2.2 0.12 13.0 0.5 2.1 1 1 1 2 2 2 0 Mga helix-turn-helix domain SdiA-regulated PF06977.11 EPA05714.1 - 0.016 14.4 0.0 0.018 14.3 0.0 1.0 1 0 0 1 1 1 0 SdiA-regulated DUF2250 PF10007.9 EPA05714.1 - 0.025 14.7 0.5 0.035 14.2 0.4 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) MarR_2 PF12802.7 EPA05714.1 - 0.035 14.0 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 EPA05714.1 - 0.037 13.6 1.0 0.076 12.6 0.3 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding YycC PF14174.6 EPA05714.1 - 0.039 13.8 0.1 0.082 12.7 0.1 1.6 1 0 0 1 1 1 0 YycC-like protein PadR PF03551.14 EPA05714.1 - 0.047 13.7 0.1 0.088 12.8 0.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family CbtA PF09490.10 EPA05715.1 - 7.6e-50 169.9 1.1 9.4e-50 169.6 1.1 1.0 1 0 0 1 1 1 1 Probable cobalt transporter subunit (CbtA) Romo1 PF10247.9 EPA05715.1 - 0.18 12.2 3.8 0.48 10.8 0.2 2.9 3 0 0 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 EMP70 PF02990.16 EPA05715.1 - 3.4 6.2 8.5 2.4 6.7 6.9 1.5 1 1 1 2 2 2 0 Endomembrane protein 70 DUF4443 PF14544.6 EPA05716.1 - 5.7e-05 23.3 0.0 8.5e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4443) HTH_45 PF14947.6 EPA05716.1 - 0.01 15.8 0.1 0.024 14.6 0.1 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix Ribosomal_S19e PF01090.19 EPA05716.1 - 0.17 11.6 0.1 0.47 10.2 0.1 1.8 1 1 0 1 1 1 0 Ribosomal protein S19e TMEMspv1-c74-12 PF11044.8 EPA05719.1 - 0.76 9.8 7.9 0.41 10.7 1.0 2.5 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Na_H_Exchanger PF00999.21 EPA05720.1 - 6.9e-35 120.5 46.8 9.4e-35 120.1 46.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family RNA_binding PF01877.17 EPA05722.1 - 2e-12 47.4 0.2 8.7e-12 45.4 0.2 1.8 1 1 0 1 1 1 1 RNA binding tRNA-synt_1g PF09334.11 EPA05722.1 - 0.0014 17.5 0.0 0.0015 17.3 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (M) SAF PF08666.12 EPA05724.1 - 0.00051 20.6 0.0 0.00052 20.6 0.0 1.0 1 0 0 1 1 1 1 SAF domain DUF3284 PF11687.8 EPA05724.1 - 0.0084 16.0 0.0 0.0084 16.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3284) Glycos_transf_1 PF00534.20 EPA05725.1 - 1.1e-33 116.3 0.2 1.6e-33 115.7 0.2 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EPA05725.1 - 2.4e-27 96.0 0.0 4.1e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EPA05725.1 - 4.3e-12 46.2 0.0 8.3e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Peptidase_S51 PF03575.17 EPA05725.1 - 0.015 15.0 0.0 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 Peptidase family S51 Glyco_transf_4 PF13439.6 EPA05725.1 - 0.02 14.9 0.0 0.089 12.8 0.0 2.0 3 0 0 3 3 3 0 Glycosyltransferase Family 4 DUF3880 PF12996.7 EPA05725.1 - 0.061 13.4 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 DUF based on E. rectale Gene description (DUF3880) Glyco_transf_4 PF13439.6 EPA05726.1 - 1.5e-06 28.3 0.0 1.6e-06 28.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EPA05726.1 - 0.0003 21.3 0.0 0.00031 21.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.11 EPA05726.1 - 0.0004 20.2 0.0 0.00041 20.1 0.0 1.0 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_2 PF13477.6 EPA05726.1 - 0.0072 16.4 0.0 0.0073 16.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl transferase 4-like EFP PF01132.20 EPA05726.1 - 0.12 12.4 0.0 0.14 12.3 0.0 1.1 1 0 0 1 1 1 0 Elongation factor P (EF-P) OB domain Epimerase_2 PF02350.19 EPA05727.1 - 3.4e-71 239.9 1.1 3.9e-71 239.7 1.1 1.0 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase MGDG_synth PF06925.11 EPA05727.1 - 0.00026 21.1 2.4 0.039 14.1 0.0 3.1 4 0 0 4 4 4 2 Monogalactosyldiacylglycerol (MGDG) synthase Ribonuclease_T2 PF00445.18 EPA05727.1 - 0.19 11.9 0.9 4.8 7.4 0.0 2.2 2 0 0 2 2 2 0 Ribonuclease T2 family NeuB PF03102.14 EPA05728.1 - 6.6e-68 228.7 0.1 8.2e-68 228.4 0.1 1.0 1 0 0 1 1 1 1 NeuB family Band_7_C PF16200.5 EPA05728.1 - 0.065 13.3 0.2 0.23 11.5 0.0 2.0 3 0 0 3 3 3 0 C-terminal region of band_7 Polysacc_synt_2 PF02719.15 EPA05729.1 - 3e-18 66.0 0.0 3.6e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RNase_Zc3h12a_2 PF14626.6 EPA05729.1 - 0.03 14.6 0.0 0.037 14.3 0.0 1.1 1 0 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain NeuB PF03102.14 EPA05730.1 - 2.6e-06 27.1 0.0 2.9e-06 26.9 0.0 1.0 1 0 0 1 1 1 1 NeuB family Epimerase PF01370.21 EPA05732.1 - 2.3e-39 135.3 0.0 2.9e-39 135.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EPA05732.1 - 3.9e-35 121.8 0.5 2.1e-33 116.1 0.0 2.2 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EPA05732.1 - 3.9e-18 65.4 1.2 1.9e-15 56.6 0.0 2.3 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EPA05732.1 - 6.5e-18 64.8 0.1 9.4e-16 57.8 0.0 2.8 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 EPA05732.1 - 8.7e-18 64.5 0.4 1.5e-15 57.1 0.0 2.7 1 1 1 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EPA05732.1 - 2.7e-15 56.2 0.0 3.5e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EPA05732.1 - 3.3e-06 27.1 0.0 7.8e-06 25.9 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding tRNA-synt_1 PF00133.22 EPA05733.1 - 7.9e-16 57.4 0.2 2.5e-15 55.8 0.2 1.6 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EPA05733.1 - 2.4e-10 39.8 0.0 3.8e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EPA05733.1 - 8.9e-07 28.5 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain CHB_HEX_C PF03174.13 EPA05733.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain LMWPc PF01451.21 EPA05734.1 - 3.1e-23 82.7 0.2 6.6e-23 81.7 0.2 1.5 1 1 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Response_reg PF00072.24 EPA05735.1 - 3e-24 85.3 0.9 3.5e-24 85.1 0.9 1.0 1 0 0 1 1 1 1 Response regulator receiver domain ADH_N PF08240.12 EPA05736.1 - 0.00045 20.1 0.0 0.00063 19.6 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ATG19_autophagy PF12744.7 EPA05737.1 - 0.015 14.5 1.9 0.018 14.2 1.7 1.3 1 1 0 1 1 1 0 Autophagy protein Atg19, Atg8-binding DUF3958 PF13125.6 EPA05737.1 - 0.054 13.7 0.2 0.064 13.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3958) DM13 PF10517.9 EPA05738.1 - 4.8e-16 59.2 0.0 6.6e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Electron transfer DM13 ThiC-associated PF13667.6 EPA05738.1 - 0.17 11.7 0.0 6.7 6.6 0.0 2.1 1 1 1 2 2 2 0 ThiC-associated domain DUF3644 PF12358.8 EPA05741.1 - 0.0097 16.4 0.5 0.13 12.8 0.2 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3644) Pribosyltran PF00156.27 EPA05742.1 - 2.6e-14 53.0 0.0 3.2e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EPA05742.1 - 0.0079 15.7 0.0 0.0098 15.3 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase MRF_C2 PF13888.6 EPA05743.1 - 0.0067 16.3 0.0 0.0082 16.0 0.0 1.2 1 0 0 1 1 1 1 Myelin gene regulatory factor C-terminal domain 2 MG2 PF01835.19 EPA05744.1 - 4.6e-11 43.0 0.0 4.5e-06 27.0 0.0 2.5 2 1 0 2 2 2 2 MG2 domain FlgD_ig PF13860.6 EPA05744.1 - 2.6e-06 27.2 0.2 0.012 15.5 0.1 2.7 2 1 0 2 2 2 2 FlgD Ig-like domain DUF4625 PF15418.6 EPA05744.1 - 0.018 15.3 0.0 1.4 9.2 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4625) DUF4882 PF16223.5 EPA05745.1 - 0.063 12.5 0.0 0.067 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4882) AAA_15 PF13175.6 EPA05746.1 - 6.3e-25 88.7 4.3 6.3e-25 88.7 4.3 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EPA05746.1 - 6.6e-13 49.1 12.8 1.2e-11 45.0 5.4 3.6 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF2813 PF11398.8 EPA05746.1 - 0.0019 17.6 0.1 1.8 7.8 0.0 3.4 4 0 0 4 4 4 2 Protein of unknown function (DUF2813) ABC_tran PF00005.27 EPA05746.1 - 0.0022 18.5 1.1 0.0073 16.8 0.1 2.4 2 1 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 EPA05746.1 - 0.0058 16.3 0.1 0.039 13.7 0.0 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_27 PF13514.6 EPA05746.1 - 0.0058 16.2 0.1 0.032 13.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain Glyco_hydro_42C PF08533.10 EPA05746.1 - 0.14 11.9 0.1 0.82 9.4 0.0 2.1 2 0 0 2 2 2 0 Beta-galactosidase C-terminal domain SMC_N PF02463.19 EPA05746.1 - 0.16 11.4 0.1 1.3 8.5 0.1 2.3 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EPA05746.1 - 3.6 8.0 24.4 0.14 12.6 14.1 3.4 2 1 0 2 2 2 0 AAA domain MG2 PF01835.19 EPA05748.1 - 3.9e-07 30.4 0.2 0.18 12.3 0.0 4.0 4 0 0 4 4 4 2 MG2 domain Big_6 PF17936.1 EPA05748.1 - 0.0019 18.4 8.9 0.016 15.5 0.2 3.5 4 1 0 4 4 4 2 Bacterial Ig domain FlgD_ig PF13860.6 EPA05748.1 - 0.0047 16.8 2.7 0.62 10.0 0.1 3.9 3 1 0 3 3 3 1 FlgD Ig-like domain FixH PF05751.11 EPA05748.1 - 0.0086 16.1 0.1 0.89 9.6 0.0 3.3 4 0 0 4 4 4 1 FixH bMG3 PF11974.8 EPA05748.1 - 0.021 14.9 0.4 1.5 8.9 0.1 3.0 3 0 0 3 3 3 0 Bacterial alpha-2-macroglobulin MG3 domain YtkA PF13115.6 EPA05748.1 - 0.062 13.9 0.1 0.62 10.7 0.0 2.8 2 0 0 2 2 2 0 YtkA-like Invasin_D3 PF09134.10 EPA05748.1 - 0.096 13.0 14.8 0.45 10.9 2.9 3.9 4 0 0 4 4 4 0 Invasin, domain 3 TIG PF01833.24 EPA05748.1 - 0.11 12.6 2.3 0.33 11.0 1.2 2.6 2 1 0 2 2 2 0 IPT/TIG domain CE2_N PF17996.1 EPA05748.1 - 0.2 11.7 0.9 4.2 7.4 0.1 3.3 3 0 0 3 3 3 0 Carbohydrate esterase 2 N-terminal CarboxypepD_reg PF13620.6 EPA05748.1 - 0.87 9.9 12.9 0.22 11.8 1.1 4.3 4 3 0 4 4 4 0 Carboxypeptidase regulatory-like domain PNP_UDP_1 PF01048.20 EPA05749.1 - 3.6e-42 144.2 0.0 4e-42 144.1 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily zinc_ribbon_2 PF13240.6 EPA05750.1 - 0.0002 21.0 10.1 0.009 15.7 1.3 2.3 1 1 2 3 3 3 3 zinc-ribbon domain zf-C4_Topoisom PF01396.19 EPA05750.1 - 0.005 16.6 7.5 0.4 10.5 0.5 2.3 2 0 0 2 2 2 2 Topoisomerase DNA binding C4 zinc finger zf-ribbon_3 PF13248.6 EPA05750.1 - 0.0062 15.9 10.3 0.064 12.7 1.8 2.2 1 1 1 2 2 2 2 zinc-ribbon domain RPA_interact_C PF14768.6 EPA05750.1 - 0.0081 16.7 4.9 0.0086 16.6 4.9 1.0 1 0 0 1 1 1 1 Replication protein A interacting C-terminal zf-ACC PF17848.1 EPA05750.1 - 0.01 15.9 2.9 1 9.5 0.4 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain FYDLN_acid PF09538.10 EPA05750.1 - 0.011 16.5 2.9 0.012 16.3 2.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) zinc-ribbons_6 PF07191.12 EPA05750.1 - 0.013 15.5 7.0 0.023 14.7 6.9 1.5 1 1 0 1 1 1 0 zinc-ribbons DZR PF12773.7 EPA05750.1 - 0.016 15.2 6.9 0.07 13.2 7.2 1.4 1 1 0 1 1 1 0 Double zinc ribbon zf-RRPl_C4 PF17026.5 EPA05750.1 - 0.02 15.0 2.4 0.02 15.0 2.4 1.0 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type A2L_zn_ribbon PF08792.10 EPA05750.1 - 0.023 14.4 5.0 0.063 13.0 5.0 1.7 1 1 0 1 1 1 0 A2L zinc ribbon domain zf-TFIIB PF13453.6 EPA05750.1 - 0.029 13.7 7.2 0.36 10.2 1.6 2.1 2 0 0 2 2 2 0 Transcription factor zinc-finger zf_UBZ PF18439.1 EPA05750.1 - 0.032 13.8 8.2 0.49 10.0 2.0 2.2 1 1 1 2 2 2 0 Ubiquitin-Binding Zinc Finger TF_Zn_Ribbon PF08271.12 EPA05750.1 - 0.075 12.6 6.3 0.13 11.9 6.3 1.5 1 1 0 1 1 1 0 TFIIB zinc-binding DUF1936 PF09151.10 EPA05750.1 - 0.088 12.7 4.0 4.1 7.4 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) DUF555 PF04475.12 EPA05750.1 - 0.094 13.0 0.9 0.43 10.9 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF555) OrfB_Zn_ribbon PF07282.11 EPA05750.1 - 0.098 12.6 5.2 0.12 12.4 5.2 1.1 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-Mss51 PF13824.6 EPA05750.1 - 0.1 12.7 6.4 0.13 12.4 6.4 1.1 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Ogr_Delta PF04606.12 EPA05750.1 - 0.14 12.2 4.9 4.5 7.3 0.7 2.2 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Zn_Tnp_IS91 PF14319.6 EPA05750.1 - 0.16 12.0 5.9 0.17 11.9 5.9 1.1 1 0 0 1 1 1 0 Transposase zinc-binding domain Ribosomal_S27e PF01667.17 EPA05750.1 - 0.17 11.6 5.2 0.27 11.0 5.2 1.4 1 1 0 1 1 1 0 Ribosomal protein S27 HypA PF01155.19 EPA05750.1 - 0.19 11.8 5.5 0.22 11.6 5.5 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2H2_10 PF18414.1 EPA05750.1 - 0.19 11.3 8.5 1.1 8.9 0.4 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger zf-FPG_IleRS PF06827.14 EPA05750.1 - 0.24 11.3 8.1 1.5 8.8 8.2 2.0 1 1 1 2 2 2 0 Zinc finger found in FPG and IleRS zf-NADH-PPase PF09297.11 EPA05750.1 - 0.26 11.0 6.9 0.35 10.6 2.5 2.2 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain NOB1_Zn_bind PF08772.11 EPA05750.1 - 0.28 11.4 6.6 0.8 9.9 6.6 1.7 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Cys_rich_KTR PF14205.6 EPA05750.1 - 0.29 10.9 8.2 9.4 6.1 8.2 2.1 1 1 0 1 1 1 0 Cysteine-rich KTR zf-ISL3 PF14690.6 EPA05750.1 - 0.53 11.0 7.7 2.8 8.7 0.5 2.2 1 1 1 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Mu-like_Com PF10122.9 EPA05750.1 - 0.75 9.3 9.4 0.48 9.9 1.3 2.1 1 1 1 2 2 2 0 Mu-like prophage protein Com Zn_ribbon_recom PF13408.6 EPA05750.1 - 0.75 10.4 6.1 64 4.2 6.1 2.1 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain RNA_POL_M_15KD PF02150.16 EPA05750.1 - 0.81 9.6 9.8 0.21 11.5 1.5 2.3 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit UPF0547 PF10571.9 EPA05750.1 - 1.1 9.4 11.8 32 4.7 11.9 2.6 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-HIT PF04438.16 EPA05750.1 - 1.2 9.1 9.1 3 7.8 0.6 2.3 2 1 0 2 2 2 0 HIT zinc finger DUF3797 PF12677.7 EPA05750.1 - 2.5 8.1 8.1 2.2 8.2 1.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) Rep_fac-A_C PF08646.10 EPA05750.1 - 2.5 7.8 6.6 2.7 7.7 6.6 1.0 1 0 0 1 1 1 0 Replication factor-A C terminal domain zinc_ribbon_4 PF13717.6 EPA05751.1 - 0.0005 19.9 3.4 0.0032 17.4 3.4 2.0 1 1 0 1 1 1 1 zinc-ribbon domain IBR PF01485.21 EPA05751.1 - 0.0014 18.8 1.0 0.0024 18.1 1.0 1.3 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain OrfB_Zn_ribbon PF07282.11 EPA05751.1 - 0.0042 17.0 0.4 0.0053 16.7 0.4 1.2 1 0 0 1 1 1 1 Putative transposase DNA-binding domain CpXC PF14353.6 EPA05751.1 - 0.0055 16.7 2.6 0.03 14.3 0.0 2.0 1 1 1 2 2 2 1 CpXC protein YacG PF03884.14 EPA05751.1 - 0.017 14.8 0.3 3.2 7.6 0.0 2.2 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG zf_C2H2_10 PF18414.1 EPA05751.1 - 0.021 14.4 1.7 1.4 8.5 0.2 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger Zn_Tnp_IS1595 PF12760.7 EPA05751.1 - 0.024 14.6 0.3 3.3 7.7 0.0 2.1 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Zn_Tnp_IS91 PF14319.6 EPA05751.1 - 0.037 14.1 0.1 0.04 14.0 0.1 1.1 1 0 0 1 1 1 0 Transposase zinc-binding domain HypA PF01155.19 EPA05751.1 - 0.053 13.6 0.2 0.054 13.5 0.2 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ogr_Delta PF04606.12 EPA05751.1 - 0.064 13.3 0.4 9.8 6.2 0.0 2.2 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger zf-H2C2_5 PF13909.6 EPA05751.1 - 0.065 13.0 0.4 0.065 13.0 0.4 1.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Ribosomal_S27e PF01667.17 EPA05751.1 - 0.086 12.6 3.3 0.25 11.1 3.3 1.7 1 1 0 1 1 1 0 Ribosomal protein S27 Prok-RING_1 PF14446.6 EPA05751.1 - 0.12 12.4 2.9 0.15 12.0 2.9 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-BED PF02892.15 EPA05751.1 - 0.16 12.0 1.6 0.8 9.8 0.1 2.1 1 1 1 2 2 2 0 BED zinc finger zf-Di19 PF05605.12 EPA05751.1 - 0.27 11.5 3.8 0.95 9.8 0.4 2.1 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-ribbon_3 PF13248.6 EPA05751.1 - 0.3 10.6 7.4 5 6.7 7.4 2.2 1 1 0 1 1 1 0 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 EPA05751.1 - 0.53 10.3 4.7 1.3 9.0 0.1 2.2 2 0 0 2 2 2 0 PhnA Zinc-Ribbon zinc_ribbon_9 PF14369.6 EPA05751.1 - 1.5 9.2 6.2 27 5.1 6.6 2.1 1 1 1 2 2 2 0 zinc-ribbon zinc_ribbon_5 PF13719.6 EPA05751.1 - 1.7 8.5 5.2 5.3 6.9 5.2 1.7 1 1 0 1 1 1 0 zinc-ribbon domain Ribosomal_S6e PF01092.19 EPA05752.1 - 5.8e-25 87.7 0.1 6.8e-25 87.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S6e GTP_EFTU PF00009.27 EPA05753.1 - 8.5e-08 32.0 1.0 3.4e-07 30.0 1.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EPA05753.1 - 0.0033 17.5 0.0 0.0036 17.4 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EPA05753.1 - 0.11 12.1 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Ferrous iron transport protein B SIMPL PF04402.14 EPA05755.1 - 4.6e-42 144.8 5.2 5.5e-42 144.5 5.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) DUF1657 PF07870.11 EPA05755.1 - 0.064 13.2 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1657) MFS_1 PF07690.16 EPA05756.1 - 1.6e-49 168.7 75.7 1.9e-45 155.3 45.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EPA05756.1 - 7.4e-09 35.0 12.3 7.4e-09 35.0 12.3 3.5 1 1 1 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EPA05756.1 - 0.0017 16.9 12.6 0.0017 16.9 12.6 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF1523 PF07509.11 EPA05756.1 - 0.11 11.8 0.2 0.11 11.8 0.2 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1523) DUF2631 PF10939.8 EPA05756.1 - 0.45 10.4 2.7 13 5.8 0.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2631) MFS_2 PF13347.6 EPA05756.1 - 2.9 6.4 45.1 0.47 8.9 4.3 4.5 1 1 2 4 4 4 0 MFS/sugar transport protein STT3 PF02516.14 EPA05757.1 - 1.4e-27 96.8 20.9 1.4e-27 96.8 20.9 2.0 1 1 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit STT3 PF02516.14 EPA05758.1 - 1.1e-06 27.8 0.1 1.4e-06 27.5 0.1 1.2 1 0 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit Dpy19 PF10034.9 EPA05758.1 - 0.036 12.3 0.1 0.062 11.5 0.1 1.3 2 0 0 2 2 2 0 Q-cell neuroblast polarisation TSP_3 PF02412.18 EPA05760.1 - 7.6e-05 22.3 1.8 0.00016 21.3 1.8 1.5 1 0 0 1 1 1 1 Thrombospondin type 3 repeat Cupredoxin_1 PF13473.6 EPA05760.1 - 0.0034 17.5 0.0 0.0057 16.7 0.0 1.6 1 1 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 EPA05760.1 - 0.057 13.9 0.0 0.12 12.9 0.0 1.6 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family DNA_binding_1 PF01035.20 EPA05761.1 - 2.6e-29 101.2 0.0 3.1e-29 100.9 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain SecE PF00584.20 EPA05762.1 - 4.5e-07 29.7 0.0 5.3e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Frag1 PF10277.9 EPA05762.1 - 0.026 14.1 0.0 0.028 13.9 0.0 1.0 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family Ribosomal_L32e PF01655.18 EPA05763.1 - 3.2e-31 108.0 0.0 3.8e-31 107.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Mnd1 PF03962.15 EPA05763.1 - 0.11 12.9 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 Mnd1 HTH domain Spt5-NGN PF03439.13 EPA05764.1 - 2.6e-20 72.1 0.0 4.1e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 EPA05764.1 - 1.7e-05 24.6 0.3 3.3e-05 23.7 0.3 1.5 1 0 0 1 1 1 1 KOW motif Ribosomal_L11_N PF03946.14 EPA05765.1 - 9.6e-23 79.8 1.3 1.7e-22 79.0 0.7 1.8 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EPA05765.1 - 1e-19 70.8 1.2 2e-19 69.9 1.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Hom_end PF05204.14 EPA05765.1 - 0.11 12.7 0.3 0.17 12.1 0.3 1.3 1 0 0 1 1 1 0 Homing endonuclease PEPCK_ATP PF01293.20 EPA05766.1 - 3.5e-215 715.0 0.0 4e-215 714.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase tRNA_deacylase PF04414.12 EPA05767.1 - 4.1e-59 199.5 0.0 5.1e-59 199.3 0.0 1.1 1 0 0 1 1 1 1 D-aminoacyl-tRNA deacylase Peptidase_S8 PF00082.22 EPA05768.1 - 4.1e-29 101.8 0.0 6e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 Subtilase family PA PF02225.22 EPA05768.1 - 1.8e-11 43.9 0.6 5.7e-11 42.3 0.0 2.2 2 0 0 2 2 2 1 PA domain Ribosomal_L19e PF01280.20 EPA05769.1 - 9.8e-39 132.7 8.4 1.2e-38 132.5 8.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L19e SpoIIM PF01944.17 EPA05770.1 - 6.1e-06 26.3 13.5 7.1e-06 26.1 13.5 1.1 1 0 0 1 1 1 1 Stage II sporulation protein M NIR_SIR_ferr PF03460.17 EPA05771.1 - 7.2e-17 61.0 0.0 1.1e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain DUF1910 PF08928.10 EPA05772.1 - 0.41 10.7 4.1 0.42 10.6 0.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1910) Thi4 PF01946.17 EPA05774.1 - 5.8e-64 215.5 0.1 7.2e-64 215.2 0.1 1.1 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 EPA05774.1 - 4.7e-15 55.6 0.2 9.7e-07 28.2 0.0 3.0 2 1 1 3 3 3 2 FAD binding domain FAD_oxidored PF12831.7 EPA05774.1 - 9.6e-11 41.7 0.0 2.2e-10 40.5 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EPA05774.1 - 5.8e-08 32.3 0.0 7.6e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EPA05774.1 - 2e-07 31.1 0.0 4.2e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EPA05774.1 - 1e-06 28.6 0.2 0.00028 20.6 0.1 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EPA05774.1 - 1.9e-06 27.3 0.0 3.3e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EPA05774.1 - 2.8e-06 26.3 0.0 4.1e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 EPA05774.1 - 4.9e-05 22.5 0.3 0.0019 17.3 0.0 2.3 2 1 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EPA05774.1 - 9.9e-05 21.7 0.0 0.00015 21.1 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EPA05774.1 - 0.00029 20.0 0.1 0.0005 19.3 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 EPA05774.1 - 0.004 16.1 0.0 1.3 7.8 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase AlaDh_PNT_C PF01262.21 EPA05774.1 - 0.0067 15.7 0.1 0.025 13.9 0.1 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 EPA05774.1 - 0.01 15.2 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EPA05774.1 - 0.011 16.3 0.1 0.064 13.8 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 EPA05774.1 - 0.046 12.2 0.0 0.1 11.1 0.0 1.5 2 0 0 2 2 2 0 GDP dissociation inhibitor NAD_binding_9 PF13454.6 EPA05774.1 - 0.064 13.2 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding TrkA_N PF02254.18 EPA05774.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain SH3BP5 PF05276.14 EPA05776.1 - 0.035 13.9 0.5 0.035 13.9 0.5 1.8 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) CC2-LZ PF16516.5 EPA05776.1 - 0.039 14.3 4.4 1.4 9.3 1.0 2.4 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Polysacc_synt_2 PF02719.15 EPA05776.1 - 0.044 12.9 0.0 0.96 8.5 0.0 2.5 2 1 0 2 2 2 0 Polysaccharide biosynthesis protein Atg14 PF10186.9 EPA05776.1 - 0.12 11.5 10.8 0.06 12.4 4.3 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlxA PF14282.6 EPA05776.1 - 0.15 12.1 20.3 0.17 11.9 8.6 3.0 2 1 1 3 3 3 0 FlxA-like protein Snapin_Pallidin PF14712.6 EPA05776.1 - 0.3 11.5 10.0 0.097 13.1 3.9 2.5 2 0 0 2 2 2 0 Snapin/Pallidin I_LWEQ PF01608.17 EPA05776.1 - 0.3 11.3 3.6 6.9 6.9 0.1 2.5 2 0 0 2 2 2 0 I/LWEQ domain LidA_Long_CC PF18641.1 EPA05776.1 - 0.63 10.1 7.4 0.087 12.9 2.8 1.9 2 0 0 2 2 2 0 LidA long coiled-coil domain Pilin PF00114.19 EPA05776.1 - 0.75 10.7 4.3 4.9 8.1 0.8 2.6 2 0 0 2 2 2 0 Pilin (bacterial filament) Seryl_tRNA_N PF02403.22 EPA05776.1 - 0.85 9.9 6.9 1.1 9.5 2.0 2.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain OmpH PF03938.14 EPA05776.1 - 0.98 9.8 6.6 4.5 7.6 0.2 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF724 PF05266.14 EPA05776.1 - 2.2 8.1 6.1 13 5.5 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF724) ABC_tran_CTD PF16326.5 EPA05776.1 - 3.1 8.1 8.1 4.5 7.6 0.5 2.9 2 1 0 2 2 2 0 ABC transporter C-terminal domain BST2 PF16716.5 EPA05776.1 - 7.7 7.2 8.2 32 5.2 0.1 2.6 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 TolA_bind_tri PF16331.5 EPA05776.1 - 8.4 6.6 12.4 1.3e+02 2.7 8.4 3.3 3 1 0 3 3 3 0 TolA binding protein trimerisation CBS PF00571.28 EPA05777.1 - 2.1e-26 92.1 3.8 1.4e-14 54.2 1.0 2.1 2 0 0 2 2 2 2 CBS domain HSBP1 PF06825.12 EPA05778.1 - 0.00033 20.4 3.8 0.058 13.3 0.3 3.2 2 1 1 3 3 3 1 Heat shock factor binding protein 1 DUF4140 PF13600.6 EPA05778.1 - 0.00046 20.6 9.6 0.044 14.2 0.9 4.0 3 1 0 3 3 3 1 N-terminal domain of unknown function (DUF4140) ATG16 PF08614.11 EPA05778.1 - 0.00065 20.0 6.3 0.28 11.4 0.8 2.4 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) TcpS PF17456.2 EPA05778.1 - 0.00067 19.7 8.2 0.055 13.5 2.8 2.6 2 0 0 2 2 2 2 Toxin-coregulated pilus protein S Med9 PF07544.13 EPA05778.1 - 0.00094 19.2 10.6 0.019 15.1 0.8 3.0 2 2 0 2 2 2 2 RNA polymerase II transcription mediator complex subunit 9 ADIP PF11559.8 EPA05778.1 - 0.00098 19.2 8.6 0.12 12.4 0.9 2.3 2 0 0 2 2 2 2 Afadin- and alpha -actinin-Binding Prefoldin_2 PF01920.20 EPA05778.1 - 0.0027 17.6 9.7 0.18 11.8 0.4 4.1 3 1 1 4 4 4 1 Prefoldin subunit NleF_casp_inhib PF16809.5 EPA05778.1 - 0.0039 17.1 10.6 0.84 9.5 0.5 3.4 2 1 1 3 3 3 2 NleF caspase inhibitor DUF848 PF05852.11 EPA05778.1 - 0.0063 16.6 5.3 0.56 10.3 1.2 2.4 2 0 0 2 2 2 1 Gammaherpesvirus protein of unknown function (DUF848) Snapin_Pallidin PF14712.6 EPA05778.1 - 0.0066 16.8 7.2 0.17 12.3 0.5 2.6 2 0 0 2 2 2 1 Snapin/Pallidin Spectrin PF00435.21 EPA05778.1 - 0.011 16.3 1.1 1 9.9 0.1 2.6 2 0 0 2 2 2 0 Spectrin repeat ABC_tran_CTD PF16326.5 EPA05778.1 - 0.015 15.6 6.2 0.2 11.9 0.1 3.1 2 1 0 2 2 2 0 ABC transporter C-terminal domain LPP PF04728.13 EPA05778.1 - 0.017 15.5 3.9 11 6.5 0.3 4.2 3 1 0 3 3 3 0 Lipoprotein leucine-zipper Shugoshin_N PF07558.11 EPA05778.1 - 0.022 14.6 11.8 0.027 14.4 0.3 4.0 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region TraF_2 PF13729.6 EPA05778.1 - 0.023 14.1 0.7 0.83 9.0 0.1 2.2 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein PI3K_P85_iSH2 PF16454.5 EPA05778.1 - 0.042 13.5 8.5 2.7 7.6 0.2 3.2 2 2 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF1664 PF07889.12 EPA05778.1 - 0.049 13.7 12.0 0.41 10.7 1.5 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Sacchrp_dh_NADP PF03435.18 EPA05778.1 - 0.064 13.5 0.6 0.6 10.4 0.1 2.3 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Fez1 PF06818.15 EPA05778.1 - 0.07 13.6 7.8 2 8.9 1.1 2.3 2 0 0 2 2 2 0 Fez1 FlaC_arch PF05377.11 EPA05778.1 - 0.072 13.5 11.7 0.37 11.2 1.4 3.5 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Filament PF00038.21 EPA05778.1 - 0.073 12.6 6.7 0.88 9.1 0.7 2.3 2 0 0 2 2 2 0 Intermediate filament protein DUF1137 PF06587.11 EPA05778.1 - 0.073 13.1 0.2 5.3 7.1 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1137) ApoO PF09769.9 EPA05778.1 - 0.08 12.9 1.5 0.3 11.1 0.2 2.2 2 1 0 2 2 2 0 Apolipoprotein O Spc7 PF08317.11 EPA05778.1 - 0.11 11.4 7.3 0.27 10.1 0.8 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein ACCA PF03255.14 EPA05778.1 - 0.13 12.1 7.1 2 8.3 0.5 2.7 2 1 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Leu_zip PF15294.6 EPA05778.1 - 0.14 11.6 9.8 0.32 10.5 1.5 2.2 2 0 0 2 2 2 0 Leucine zipper USP8_interact PF08941.10 EPA05778.1 - 0.17 11.7 1.6 8 6.2 0.3 2.4 2 0 0 2 2 2 0 USP8 interacting DUF148 PF02520.17 EPA05778.1 - 0.22 11.6 6.3 0.32 11.1 2.3 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF148 Laminin_II PF06009.12 EPA05778.1 - 0.23 11.5 14.4 0.63 10.1 2.2 2.7 2 2 0 2 2 2 0 Laminin Domain II FliJ PF02050.16 EPA05778.1 - 0.23 11.7 2.0 6.6 7.0 0.0 2.7 2 1 0 2 2 2 0 Flagellar FliJ protein THOC7 PF05615.13 EPA05778.1 - 0.24 11.7 9.7 3.8 7.8 1.4 3.2 2 1 0 2 2 2 0 Tho complex subunit 7 DUF4094 PF13334.6 EPA05778.1 - 0.29 11.6 12.1 0.6 10.6 0.4 3.5 4 0 0 4 4 3 0 Domain of unknown function (DUF4094) Cnn_1N PF07989.11 EPA05778.1 - 0.39 10.9 9.1 10 6.3 0.3 3.2 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 NPV_P10 PF05531.12 EPA05778.1 - 0.55 10.7 11.2 1.2 9.6 0.6 3.4 3 1 0 3 3 2 0 Nucleopolyhedrovirus P10 protein Ax_dynein_light PF10211.9 EPA05778.1 - 0.72 9.8 9.0 2.7 7.9 1.8 2.4 2 0 0 2 2 2 0 Axonemal dynein light chain FlxA PF14282.6 EPA05778.1 - 0.72 9.9 13.5 1 9.4 2.5 3.3 2 2 0 2 2 2 0 FlxA-like protein DUF724 PF05266.14 EPA05778.1 - 0.9 9.3 8.9 5.7 6.7 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Syntaxin_2 PF14523.6 EPA05778.1 - 0.94 9.9 13.0 2.8 8.3 2.2 2.5 2 0 0 2 2 2 0 Syntaxin-like protein BST2 PF16716.5 EPA05778.1 - 1.2 9.7 14.6 1.7 9.3 0.5 4.1 3 1 1 4 4 4 0 Bone marrow stromal antigen 2 Tropomyosin_1 PF12718.7 EPA05778.1 - 1.3 9.1 11.0 1.5 9.0 0.5 2.7 2 2 0 2 2 2 0 Tropomyosin like LUC7 PF03194.15 EPA05778.1 - 1.4 8.6 6.7 1.1 8.8 1.2 2.3 2 0 0 2 2 2 0 LUC7 N_terminus DUF1192 PF06698.11 EPA05778.1 - 1.5 8.9 6.8 25 5.0 0.5 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1192) DUF1515 PF07439.11 EPA05778.1 - 1.5 8.9 4.0 2.5 8.2 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1515) Baculo_PEP_C PF04513.12 EPA05778.1 - 1.5 8.9 12.8 4.7 7.2 4.0 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus HIP1_clath_bdg PF16515.5 EPA05778.1 - 1.6 9.4 7.0 20 5.9 1.6 3.1 2 2 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Uso1_p115_C PF04871.13 EPA05778.1 - 1.8 8.9 9.8 1.9 8.9 1.3 3.1 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Seryl_tRNA_N PF02403.22 EPA05778.1 - 2.1 8.6 11.5 9.7 6.5 3.0 3.2 2 2 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF5001 PF16392.5 EPA05778.1 - 2.1 8.3 7.6 0.48 10.4 0.2 3.1 3 1 0 3 3 2 0 Ig-like domain Prefoldin PF02996.17 EPA05778.1 - 2.3 8.2 11.4 4.7 7.2 0.7 4.1 3 1 1 4 4 4 0 Prefoldin subunit FAM76 PF16046.5 EPA05778.1 - 3.3 7.0 9.0 1.2 8.5 1.1 2.3 2 0 0 2 2 2 0 FAM76 protein Lebercilin PF15619.6 EPA05778.1 - 3.6 7.2 10.5 3.5 7.3 0.5 2.6 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease T4SS PF07996.11 EPA05778.1 - 3.8 7.9 9.6 1.1 9.7 1.8 2.9 2 1 1 3 3 3 0 Type IV secretion system proteins MIP-T3_C PF17749.1 EPA05778.1 - 3.9 7.4 12.2 9.6 6.2 1.3 3.3 2 1 1 3 3 3 0 Microtubule-binding protein MIP-T3 C-terminal region TssO PF17561.2 EPA05778.1 - 4.1 7.5 12.0 0.37 10.9 1.1 2.7 2 1 0 2 2 2 0 Type VI secretion system, TssO Lectin_N PF03954.14 EPA05778.1 - 5.1 6.8 8.9 1.5 8.5 0.3 2.9 2 2 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF4200 PF13863.6 EPA05778.1 - 6.8 7.1 15.6 1.3 9.4 0.3 4.0 2 2 2 4 4 4 0 Domain of unknown function (DUF4200) YabA PF06156.13 EPA05778.1 - 9.6 6.9 9.3 19 5.9 2.6 3.2 2 2 0 2 2 2 0 Initiation control protein YabA STI1 PF17830.1 EPA05780.1 - 0.00014 21.7 44.5 0.0011 18.8 16.3 3.6 1 1 2 3 3 3 3 STI1 domain Bep_C_terminal PF17841.1 EPA05780.1 - 0.0033 17.6 5.0 0.3 11.3 0.0 2.5 1 1 1 2 2 2 2 BID domain of Bartonella effector protein (Bep) GerD PF17898.1 EPA05780.1 - 0.0042 17.0 37.8 0.0053 16.7 16.2 2.9 1 1 2 3 3 3 1 Spore germination GerD central core domain Sulfotransfer_3 PF13469.6 EPA05780.1 - 0.02 15.3 3.4 0.02 15.3 3.4 1.6 1 1 1 2 2 2 0 Sulfotransferase family DUF3172 PF11371.8 EPA05780.1 - 0.035 13.8 0.1 0.058 13.1 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3172) PutA_N PF18083.1 EPA05780.1 - 0.061 13.4 11.1 0.53 10.3 2.8 2.6 1 1 0 2 2 2 0 Proline utilization A N-terminal domain DUF1221 PF06760.11 EPA05780.1 - 0.11 12.0 2.8 0.13 11.8 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1221) Cupin_4 PF08007.12 EPA05780.1 - 0.33 10.4 8.0 0.55 9.6 8.0 1.5 1 1 0 1 1 1 0 Cupin superfamily protein XPC-binding PF09280.11 EPA05780.1 - 3 7.7 19.2 6.3 6.6 7.3 3.6 2 1 0 3 3 3 0 XPC-binding domain DUF2065 PF09838.9 EPA05780.1 - 8.2 6.5 8.3 44 4.2 0.6 3.7 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2065) Spore_YhaL PF14147.6 EPA05780.1 - 10 5.9 6.8 37 4.1 2.0 2.6 2 0 0 2 2 2 0 Sporulation protein YhaL GSDH PF07995.11 EPA05781.1 - 5e-72 243.0 0.1 5.8e-72 242.8 0.1 1.0 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Proteasome_A_N PF10584.9 EPA05781.1 - 0.0025 17.4 1.1 0.12 12.1 0.1 2.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF5122 PF17164.4 EPA05781.1 - 0.03 14.6 2.1 0.49 10.7 2.3 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller SGL PF08450.12 EPA05781.1 - 0.085 12.4 0.0 13 5.3 0.0 2.3 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region PriA_CRR PF18319.1 EPA05782.1 - 0.024 14.6 0.4 0.024 14.6 0.4 1.9 3 0 0 3 3 3 0 PriA DNA helicase Cys-rich region (CRR) domain Cytochrom_NNT PF03264.14 EPA05782.1 - 0.035 13.8 1.2 0.038 13.7 1.2 1.0 1 0 0 1 1 1 0 NapC/NirT cytochrome c family, N-terminal region OrfB_Zn_ribbon PF07282.11 EPA05782.1 - 0.77 9.7 8.2 0.21 11.5 5.2 1.6 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zf-RanBP PF00641.18 EPA05782.1 - 1.1 8.6 10.0 0.077 12.3 3.8 2.2 2 1 0 2 2 2 0 Zn-finger in Ran binding protein and others Rep_fac-A_C PF08646.10 EPA05782.1 - 3.2 7.5 7.7 4.2 7.1 7.7 1.3 1 1 0 1 1 1 0 Replication factor-A C terminal domain Response_reg PF00072.24 EPA05783.1 - 5.5e-24 84.5 1.1 6.3e-24 84.3 1.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain LMWPc PF01451.21 EPA05784.1 - 4.4e-24 85.5 0.2 9.2e-24 84.4 0.2 1.5 1 1 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase ADH_N PF08240.12 EPA05785.1 - 0.00074 19.4 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AAA_PrkA PF08298.11 EPA05785.1 - 0.011 14.6 0.1 0.013 14.5 0.1 1.0 1 0 0 1 1 1 0 PrkA AAA domain ABC_tran PF00005.27 EPA05786.1 - 4.8e-17 62.8 0.1 6.3e-10 39.7 0.0 3.2 2 1 0 2 2 2 2 ABC transporter UvrA_DNA-bind PF17755.1 EPA05786.1 - 8e-16 58.4 0.1 1.5e-13 51.1 0.0 3.6 4 0 0 4 4 4 1 UvrA DNA-binding domain AAA_21 PF13304.6 EPA05786.1 - 1.2e-08 35.1 0.6 0.077 12.8 0.0 3.3 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EPA05786.1 - 1.4e-08 34.5 0.3 0.067 12.6 0.0 3.1 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EPA05786.1 - 1.5e-05 24.9 1.8 0.051 13.3 0.2 3.2 2 1 0 3 3 3 1 AAA ATPase domain DnaJ_CXXCXGXG PF00684.19 EPA05786.1 - 0.00022 21.5 1.7 0.013 15.8 0.4 2.4 2 0 0 2 2 2 1 DnaJ central domain RsgA_GTPase PF03193.16 EPA05786.1 - 0.00033 20.6 0.3 0.00098 19.1 0.3 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EPA05786.1 - 0.00066 20.1 0.0 0.014 15.8 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain NB-ARC PF00931.22 EPA05786.1 - 0.0034 16.6 0.0 0.037 13.2 0.0 2.5 3 0 0 3 3 3 1 NB-ARC domain AAA_29 PF13555.6 EPA05786.1 - 0.0067 16.2 0.1 0.016 14.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EPA05786.1 - 0.01 15.9 0.1 0.06 13.4 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase Viral_helicase1 PF01443.18 EPA05786.1 - 0.01 15.6 0.1 0.029 14.1 0.1 1.8 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EPA05786.1 - 0.016 15.5 0.3 0.33 11.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain RACo_linker PF17650.1 EPA05786.1 - 0.016 15.0 0.1 5.4 7.0 0.0 2.9 3 0 0 3 3 3 0 RACo linker region AAA_14 PF13173.6 EPA05786.1 - 0.063 13.3 0.0 1.3 9.1 0.0 2.9 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 EPA05786.1 - 0.065 12.8 0.2 0.22 11.1 0.1 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EPA05786.1 - 0.068 12.7 0.1 0.36 10.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF2972 PF11186.8 EPA05786.1 - 0.08 12.8 0.2 0.26 11.2 0.0 1.9 2 0 0 2 2 1 0 Protein of unknown function (DUF2972) ATPase_2 PF01637.18 EPA05786.1 - 0.083 12.8 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea T4_Rnl2_C PF18043.1 EPA05786.1 - 0.091 12.9 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 T4 RNA ligase 2 C-terminal MeaB PF03308.16 EPA05786.1 - 0.13 11.2 0.2 0.39 9.7 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EPA05786.1 - 0.29 10.8 1.7 17 5.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain UvrA_DNA-bind PF17755.1 EPA05787.1 - 0.056 13.8 0.0 0.067 13.5 0.0 1.1 1 0 0 1 1 1 0 UvrA DNA-binding domain GIY-YIG PF01541.24 EPA05788.1 - 1.7e-12 47.5 0.7 2.2e-12 47.1 0.7 1.1 1 0 0 1 1 1 1 GIY-YIG catalytic domain Codanin-1_C PF15296.6 EPA05788.1 - 0.084 13.0 0.2 0.18 11.9 0.1 1.4 1 1 0 1 1 1 0 Codanin-1 C-terminus HemolysinCabind PF00353.19 EPA05789.1 - 7.9e-38 128.0 79.2 5e-10 39.2 10.3 4.5 1 1 0 4 4 4 4 RTX calcium-binding nonapeptide repeat (4 copies) HGTP_anticodon PF03129.20 EPA05790.1 - 7.2e-17 61.3 0.3 2.1e-16 59.8 0.1 1.8 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EPA05790.1 - 2.9e-12 46.9 0.5 5.9e-11 42.7 0.5 2.4 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) zf-TFIIB PF13453.6 EPA05790.1 - 0.13 11.6 0.7 8.3 5.8 0.1 2.6 2 0 0 2 2 2 0 Transcription factor zinc-finger zinc_ribbon_15 PF17032.5 EPA05790.1 - 0.26 12.1 2.2 0.5 11.1 0.8 2.2 2 1 1 3 3 3 0 zinc-ribbon family zinc_ribbon_4 PF13717.6 EPA05790.1 - 0.48 10.4 4.2 9.7 6.2 0.5 2.8 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.6 EPA05790.1 - 1.1 9.1 7.4 2.9 7.7 1.4 3.0 3 0 0 3 3 3 0 zinc-ribbon domain AP_endonuc_2 PF01261.24 EPA05792.1 - 1.2e-34 119.6 0.0 2.5e-34 118.6 0.0 1.5 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel DUF3445 PF11927.8 EPA05792.1 - 0.12 12.0 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3445) CbiD PF01888.17 EPA05796.1 - 4.8e-08 32.6 0.2 8e-08 31.9 0.2 1.4 1 0 0 1 1 1 1 CbiD DUF917 PF06032.12 EPA05796.1 - 0.11 11.4 0.1 0.12 11.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF917) DUF3473 PF11959.8 EPA05797.1 - 3.5e-35 120.9 0.0 4e-35 120.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3473) HAD_2 PF13419.6 EPA05798.1 - 1.7e-05 25.0 0.1 2.8e-05 24.3 0.1 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EPA05798.1 - 0.00015 22.1 0.0 0.00021 21.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hypoth_Ymh PF09509.10 EPA05798.1 - 0.092 12.6 0.0 0.19 11.6 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (Hypoth_ymh) IGPD PF00475.18 EPA05799.1 - 1.7e-13 51.1 1.3 3.8e-13 50.0 1.2 1.5 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase DUF948 PF06103.11 EPA05800.1 - 0.044 14.1 0.4 6.5 7.1 0.0 2.4 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DASH_Duo1 PF08651.10 EPA05800.1 - 0.084 12.7 0.6 0.2 11.5 0.1 1.9 3 0 0 3 3 3 0 DASH complex subunit Duo1 Snf7 PF03357.21 EPA05800.1 - 0.091 12.3 2.5 0.2 11.2 2.5 1.6 1 1 0 1 1 1 0 Snf7 DUF1189 PF06691.11 EPA05801.1 - 0.027 14.0 6.4 0.067 12.7 6.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) SpoIIIAH PF12685.7 EPA05801.1 - 0.27 11.0 1.3 0.48 10.2 1.3 1.4 1 1 0 1 1 1 0 SpoIIIAH-like protein TP_methylase PF00590.20 EPA05804.1 - 3.1e-46 158.0 0.0 3.7e-46 157.8 0.0 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases UvrA_inter PF17760.1 EPA05804.1 - 0.004 17.2 0.1 0.09 12.9 0.0 2.4 2 0 0 2 2 2 1 UvrA interaction domain Radical_SAM PF04055.21 EPA05804.1 - 0.0098 16.3 0.1 0.017 15.5 0.1 1.5 1 1 0 1 1 1 1 Radical SAM superfamily Aldolase PF01081.19 EPA05804.1 - 0.014 14.8 0.1 0.03 13.7 0.1 1.5 1 0 0 1 1 1 0 KDPG and KHG aldolase TP_methylase PF00590.20 EPA05806.1 - 2.9e-56 190.8 0.0 3.2e-56 190.6 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases 4HB_MCP_1 PF12729.7 EPA05807.1 - 0.032 13.8 0.8 0.041 13.4 0.8 1.1 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction GATase_3 PF07685.14 EPA05808.1 - 3.5e-41 141.0 0.2 4.1e-41 140.8 0.2 1.0 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 EPA05808.1 - 2.7e-05 24.1 0.0 2.7e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 SNO glutamine amidotransferase family DUF1836 PF08876.11 EPA05808.1 - 0.032 14.3 0.7 0.057 13.5 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1836) Peptidase_S51 PF03575.17 EPA05808.1 - 0.037 13.7 0.0 0.047 13.3 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S51 CbiC PF02570.15 EPA05809.1 - 2.8e-16 59.7 0.2 3.1e-16 59.6 0.2 1.0 1 0 0 1 1 1 1 Precorrin-8X methylmutase CbiX PF01903.17 EPA05810.1 - 4e-36 123.6 0.0 3.4e-17 62.7 0.0 2.1 2 0 0 2 2 2 2 CbiX CbiK PF06180.11 EPA05810.1 - 1e-09 38.1 1.5 1.2e-09 37.9 1.5 1.1 1 0 0 1 1 1 1 Cobalt chelatase (CbiK) Ferrochelatase PF00762.19 EPA05810.1 - 2.5e-07 30.1 0.1 0.00069 18.8 0.0 2.0 1 1 1 2 2 2 2 Ferrochelatase CbiG_N PF11760.8 EPA05811.1 - 9.5e-34 115.3 0.2 1.5e-33 114.6 0.2 1.3 1 0 0 1 1 1 1 Cobalamin synthesis G N-terminal CbiG_C PF01890.16 EPA05811.1 - 6.3e-27 94.4 0.4 1.3e-26 93.5 0.2 1.6 2 0 0 2 2 2 1 Cobalamin synthesis G C-terminus CbiG_mid PF11761.8 EPA05811.1 - 5.8e-15 55.2 0.0 1.9e-14 53.5 0.0 1.9 2 0 0 2 2 2 1 Cobalamin biosynthesis central region SpoU_sub_bind PF08032.12 EPA05811.1 - 0.12 12.7 0.0 0.49 10.7 0.0 2.0 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding CbiC PF02570.15 EPA05812.1 - 1.4e-38 132.5 0.6 1.6e-38 132.4 0.6 1.0 1 0 0 1 1 1 1 Precorrin-8X methylmutase DUF4958 PF16319.5 EPA05812.1 - 0.01 13.9 0.0 0.011 13.8 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4958) DNA_primase_S PF01896.19 EPA05813.1 - 0.0032 17.5 0.0 0.0044 17.1 0.0 1.2 1 0 0 1 1 1 1 DNA primase small subunit AAA_lid_3 PF17862.1 EPA05815.1 - 6.9e-10 38.6 0.4 1.7e-09 37.3 0.4 1.7 1 1 0 1 1 1 1 AAA+ lid domain GatD_N PF18195.1 EPA05816.1 - 7.2e-17 60.5 0.2 9.3e-17 60.1 0.2 1.2 1 0 0 1 1 1 1 GatD N-terminal domain Cu_bind_CorA PF18252.1 EPA05817.1 - 0.093 12.3 0.1 1.6 8.3 0.0 2.0 2 0 0 2 2 2 0 Copper(I)-binding protein CorA PAP2 PF01569.21 EPA05818.1 - 2e-17 63.2 0.9 2.3e-17 63.1 0.9 1.0 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EPA05818.1 - 7.3e-10 38.8 1.5 8.8e-10 38.6 1.5 1.1 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 EPA05818.1 - 4.8e-06 27.0 0.2 6.4e-06 26.6 0.2 1.1 1 0 0 1 1 1 1 PAP2 superfamily C-terminal DUF212 PF02681.14 EPA05818.1 - 0.042 14.0 0.7 2 8.5 0.1 2.1 1 1 1 2 2 2 0 Divergent PAP2 family Spc7 PF08317.11 EPA05819.1 - 0.0025 16.7 23.0 0.0025 16.7 23.0 3.0 1 1 2 3 3 3 2 Spc7 kinetochore protein MscS_porin PF12795.7 EPA05819.1 - 0.13 11.8 42.0 0.028 14.0 22.8 2.2 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain TMPIT PF07851.13 EPA05819.1 - 0.32 10.2 32.1 0.93 8.7 18.5 2.2 2 0 0 2 2 2 0 TMPIT-like protein ERM PF00769.19 EPA05819.1 - 0.7 9.7 48.8 0.58 9.9 30.7 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family MtrG PF04210.13 EPA05819.1 - 0.98 9.3 2.4 2 8.3 0.8 2.4 2 1 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G AAA_13 PF13166.6 EPA05819.1 - 1.3 7.6 40.1 0.067 11.8 31.7 2.2 1 1 1 2 2 2 0 AAA domain DUF745 PF05335.13 EPA05819.1 - 4.5 7.0 37.1 1.2 8.8 11.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF745) FPP PF05911.11 EPA05819.1 - 4.6 5.3 43.5 32 2.5 43.5 1.9 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil DUF4404 PF14357.6 EPA05819.1 - 9.7 6.9 33.6 2.8 8.7 5.0 4.4 1 1 3 5 5 5 0 Domain of unknown function (DUF4404) MAD PF05557.13 EPA05819.1 - 9.7 4.4 45.8 69 1.6 45.9 1.8 1 1 0 1 1 1 0 Mitotic checkpoint protein CTP_synth_N PF06418.14 EPA05820.1 - 3.4e-117 390.4 0.3 4.8e-117 390.0 0.3 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EPA05820.1 - 1.1e-54 185.1 0.0 1.9e-54 184.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EPA05820.1 - 1.3e-12 47.9 0.0 3.9e-11 43.1 0.0 2.3 1 1 1 2 2 2 1 Peptidase C26 CbiA PF01656.23 EPA05820.1 - 0.014 15.4 0.0 0.04 14.0 0.0 1.8 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain DJ-1_PfpI PF01965.24 EPA05820.1 - 0.041 13.7 0.0 0.094 12.5 0.0 1.6 1 0 0 1 1 1 0 DJ-1/PfpI family AAA_31 PF13614.6 EPA05820.1 - 0.093 12.6 0.1 0.46 10.4 0.0 2.2 3 0 0 3 3 3 0 AAA domain zf-C2H2_4 PF13894.6 EPA05822.1 - 0.00072 20.2 11.8 0.047 14.5 1.2 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EPA05822.1 - 0.0017 18.7 13.9 0.1 13.1 3.7 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zinc_ribbon_9 PF14369.6 EPA05822.1 - 0.0048 17.1 2.6 0.03 14.6 0.2 2.2 2 0 0 2 2 2 1 zinc-ribbon Prok-RING_1 PF14446.6 EPA05822.1 - 0.0057 16.6 4.9 1 9.3 0.2 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 1 zf-C2H2_3rep PF18868.1 EPA05822.1 - 0.0073 17.0 6.3 0.012 16.3 6.3 1.4 1 1 0 1 1 1 1 Zinc finger C2H2-type, 3 repeats zf-H2C2_2 PF13465.6 EPA05822.1 - 0.008 16.6 5.3 0.008 16.6 5.3 2.8 3 0 0 3 3 2 1 Zinc-finger double domain zf-C2H2_2 PF12756.7 EPA05822.1 - 0.014 15.7 5.0 0.014 15.7 5.0 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.5 EPA05822.1 - 0.019 15.7 2.6 0.023 15.4 2.6 1.4 1 0 0 1 1 1 0 zinc-ribbon family zf-C2H2_jaz PF12171.8 EPA05822.1 - 0.022 15.0 16.5 0.34 11.3 4.9 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-CHCC PF10276.9 EPA05822.1 - 0.047 13.7 0.9 2 8.5 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger domain DUF629 PF04780.12 EPA05822.1 - 0.05 12.1 16.7 0.1 11.1 4.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-CSL PF05207.13 EPA05822.1 - 0.082 12.7 1.8 0.15 11.8 1.2 1.6 1 1 1 2 2 2 0 CSL zinc finger zf-HYPF PF07503.12 EPA05822.1 - 0.1 12.4 5.3 0.24 11.2 1.1 2.3 2 0 0 2 2 2 0 HypF finger zf-BED PF02892.15 EPA05822.1 - 0.15 12.1 8.8 8.5 6.5 1.4 2.4 1 1 1 2 2 2 0 BED zinc finger Ribosomal_S27e PF01667.17 EPA05822.1 - 0.16 11.7 3.8 0.42 10.4 3.8 1.8 1 1 0 1 1 1 0 Ribosomal protein S27 zinc_ribbon_4 PF13717.6 EPA05822.1 - 0.38 10.7 4.7 5.4 7.0 4.7 2.1 1 1 0 1 1 1 0 zinc-ribbon domain PyrI_C PF02748.15 EPA05822.1 - 0.44 10.5 6.1 0.12 12.3 1.3 2.0 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain LIM PF00412.22 EPA05822.1 - 0.5 10.6 10.2 0.53 10.6 9.2 1.5 1 1 1 2 2 2 0 LIM domain XPA_N PF01286.18 EPA05822.1 - 0.58 10.3 5.6 1.9 8.6 0.4 2.2 2 0 0 2 2 2 0 XPA protein N-terminal zinc_ribbon_5 PF13719.6 EPA05822.1 - 1 9.2 6.1 4.5 7.1 6.1 1.9 1 1 0 1 1 1 0 zinc-ribbon domain DNA_RNApol_7kD PF03604.13 EPA05822.1 - 2 8.2 6.3 0.98 9.2 0.8 2.2 1 1 2 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit FOXP-CC PF16159.5 EPA05822.1 - 2.2 9.0 12.5 13 6.5 8.5 2.3 1 1 1 2 2 2 0 FOXP coiled-coil domain Ribosomal_L37e PF01907.19 EPA05822.1 - 2.4 8.4 9.0 7.5 6.8 4.8 2.3 2 0 0 2 2 2 0 Ribosomal protein L37e Zn-ribbon_8 PF09723.10 EPA05822.1 - 2.7 8.2 5.8 3.6 7.8 1.0 2.0 1 1 1 2 2 2 0 Zinc ribbon domain FYVE PF01363.21 EPA05822.1 - 4.8 7.4 10.8 87 3.4 10.8 2.1 1 1 0 1 1 1 0 FYVE zinc finger YdjO PF14169.6 EPA05825.1 - 0.018 14.8 0.1 0.023 14.4 0.1 1.2 1 0 0 1 1 1 0 Cold-inducible protein YdjO Chorismate_bind PF00425.18 EPA05826.1 - 4.8e-92 308.2 0.0 2.2e-91 306.0 0.0 2.0 2 1 1 3 3 3 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 EPA05826.1 - 7.6e-22 78.1 0.4 6.8e-19 68.5 0.1 3.0 2 1 1 3 3 3 2 Anthranilate synthase component I, N terminal region FlbD PF06289.11 EPA05826.1 - 0.084 12.5 0.0 0.38 10.4 0.0 2.1 2 0 0 2 2 2 0 Flagellar and Swarming motility proteins NAD_kinase PF01513.21 EPA05828.1 - 1.2e-30 106.7 0.3 2.2e-30 105.9 0.3 1.4 2 0 0 2 2 2 1 ATP-NAD kinase HTH_24 PF13412.6 EPA05828.1 - 4.2e-05 23.0 0.6 0.0002 20.9 0.0 2.4 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 EPA05828.1 - 0.00013 21.7 0.8 0.013 15.4 0.1 2.8 2 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 EPA05828.1 - 0.0017 18.3 0.9 0.0054 16.6 0.1 2.2 3 0 0 3 3 3 1 MarR family RNA_pol_Rpc34 PF05158.12 EPA05828.1 - 0.01 15.2 0.2 0.016 14.6 0.2 1.2 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit TPALS PF18178.1 EPA05828.1 - 0.013 15.0 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 TIR- and PNP-associating SLOG family MarR_2 PF12802.7 EPA05828.1 - 0.014 15.2 0.0 0.048 13.6 0.0 1.9 2 0 0 2 2 2 0 MarR family B-block_TFIIIC PF04182.12 EPA05828.1 - 3.4 7.9 4.7 7.5 6.8 0.1 2.9 3 1 1 4 4 4 0 B-block binding subunit of TFIIIC Hint PF01079.20 EPA05830.1 - 0.02 14.4 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Hint module DUF4956 PF16316.5 EPA05830.1 - 0.085 12.5 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4956) Trp_syntA PF00290.20 EPA05831.1 - 8.4e-83 277.2 1.4 9.3e-83 277.0 1.4 1.0 1 0 0 1 1 1 1 Tryptophan synthase alpha chain His_biosynth PF00977.21 EPA05831.1 - 4.5e-08 32.8 0.3 1.7e-07 31.0 0.1 1.9 2 0 0 2 2 2 1 Histidine biosynthesis protein DHO_dh PF01180.21 EPA05831.1 - 3.5e-07 29.7 1.1 4.8e-07 29.3 1.1 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 EPA05831.1 - 4.1e-05 22.8 0.1 0.0003 19.9 0.0 2.3 1 1 1 3 3 3 1 FMN-dependent dehydrogenase NanE PF04131.14 EPA05831.1 - 4.1e-05 22.9 0.5 0.00058 19.1 0.1 2.7 3 0 0 3 3 3 1 Putative N-acetylmannosamine-6-phosphate epimerase PcrB PF01884.17 EPA05831.1 - 6.6e-05 22.5 2.4 0.00052 19.5 2.4 2.2 1 1 0 1 1 1 1 PcrB family IMPDH PF00478.25 EPA05831.1 - 0.00024 20.2 0.6 0.001 18.1 0.2 2.1 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 EPA05831.1 - 0.0016 17.8 0.1 0.0034 16.7 0.0 1.6 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG IGPS PF00218.21 EPA05831.1 - 0.0032 16.7 0.0 0.024 13.8 0.0 2.0 1 1 1 2 2 2 1 Indole-3-glycerol phosphate synthase Dus PF01207.17 EPA05831.1 - 0.0066 15.6 0.0 0.04 13.0 0.0 2.0 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) NMO PF03060.15 EPA05831.1 - 0.0093 15.4 0.0 0.018 14.5 0.0 1.5 1 0 0 1 1 1 1 Nitronate monooxygenase TMP-TENI PF02581.17 EPA05831.1 - 0.012 14.9 0.6 0.04 13.2 0.6 2.0 1 1 0 1 1 1 0 Thiamine monophosphate synthase BtpA PF03437.15 EPA05831.1 - 0.015 14.7 1.7 0.12 11.8 0.6 2.3 1 1 2 3 3 3 0 BtpA family TGT PF01702.18 EPA05831.1 - 0.038 13.1 0.0 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 Queuine tRNA-ribosyltransferase Ribul_P_3_epim PF00834.19 EPA05831.1 - 0.057 12.8 0.3 0.088 12.2 0.3 1.5 1 1 0 1 1 1 0 Ribulose-phosphate 3 epimerase family PALP PF00291.25 EPA05832.1 - 6.4e-45 153.8 0.8 7.6e-45 153.6 0.8 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Succ_CoA_lig PF13607.6 EPA05832.1 - 0.063 13.1 0.1 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain PAC2 PF09754.9 EPA05833.1 - 2.4e-26 93.1 0.0 2.6e-26 92.9 0.0 1.0 1 0 0 1 1 1 1 PAC2 family LpxI_N PF17930.1 EPA05833.1 - 0.047 13.6 0.0 0.083 12.8 0.0 1.5 1 0 0 1 1 1 0 LpxI N-terminal domain PDDEXK_1 PF12705.7 EPA05834.1 - 4.9e-07 29.9 0.0 1.1e-06 28.7 0.0 1.4 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily DUF2800 PF10926.8 EPA05834.1 - 0.013 14.8 0.3 1.2 8.3 0.2 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2800) Cas_Cas4 PF01930.17 EPA05834.1 - 0.028 14.6 0.0 0.044 13.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF83 PMT_2 PF13231.6 EPA05836.1 - 2.4e-08 34.4 19.1 2.4e-08 34.4 19.1 3.4 3 1 1 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase SLATT_fungal PF18142.1 EPA05836.1 - 0.22 11.5 0.5 0.48 10.4 0.5 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain DUF3681 PF12442.8 EPA05836.1 - 3.8 8.0 8.8 0.62 10.6 0.7 3.3 2 1 2 4 4 4 0 Protein of unknown function (DUF3681) RecR PF02132.15 EPA05838.1 - 0.052 13.1 0.0 0.059 12.9 0.0 1.2 1 0 0 1 1 1 0 RecR protein GATase PF00117.28 EPA05839.1 - 9.4e-53 178.8 0.0 1.1e-52 178.6 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EPA05839.1 - 3.8e-09 36.6 0.9 1.9e-08 34.3 0.9 1.9 1 1 0 1 1 1 1 Peptidase C26 SNO PF01174.19 EPA05839.1 - 5.3e-05 23.1 0.1 0.00019 21.3 0.0 1.8 2 0 0 2 2 2 1 SNO glutamine amidotransferase family zf-met2 PF12907.7 EPA05841.1 - 0.0017 18.4 0.8 0.0031 17.6 0.8 1.7 1 1 0 1 1 1 1 Zinc-binding zf-C2H2_4 PF13894.6 EPA05841.1 - 0.038 14.8 4.3 0.14 13.1 4.3 1.9 1 1 0 1 1 1 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.5 EPA05842.1 - 0.0058 17.4 0.2 0.0075 17.0 0.2 1.2 1 0 0 1 1 1 1 zinc-ribbon family zf-LITAF-like PF10601.9 EPA05842.1 - 0.0068 16.6 0.5 0.65 10.3 0.0 2.2 2 0 0 2 2 2 2 LITAF-like zinc ribbon domain TF_Zn_Ribbon PF08271.12 EPA05842.1 - 0.041 13.4 4.0 0.52 9.9 4.0 2.2 1 1 0 1 1 1 0 TFIIB zinc-binding Glycos_transf_2 PF00535.26 EPA05843.1 - 3.8e-34 117.9 0.0 8.7e-34 116.8 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 GtrA PF04138.14 EPA05843.1 - 2.8e-24 85.6 11.4 4.6e-23 81.7 12.3 2.2 1 1 0 1 1 1 1 GtrA-like protein Glyco_tranf_2_3 PF13641.6 EPA05843.1 - 2.1e-10 40.9 0.0 3.1e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EPA05843.1 - 0.0065 16.0 0.0 0.013 15.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 NTP_transf_3 PF12804.7 EPA05843.1 - 0.032 14.6 0.0 0.048 14.0 0.0 1.2 1 0 0 1 1 1 0 MobA-like NTP transferase domain Glyco_tranf_2_2 PF10111.9 EPA05843.1 - 0.038 13.5 0.0 0.06 12.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 RecR PF02132.15 EPA05846.1 - 0.0096 15.5 3.0 0.012 15.2 3.0 1.2 1 0 0 1 1 1 1 RecR protein C1_2 PF03107.16 EPA05846.1 - 0.041 14.2 2.6 0.067 13.5 2.6 1.4 1 1 0 1 1 1 0 C1 domain FeoB_associated PF12669.7 EPA05846.1 - 0.09 13.2 7.3 0.16 12.4 7.3 1.4 1 1 0 1 1 1 0 FeoB-associated Cys-rich membrane protein YyzF PF14116.6 EPA05846.1 - 0.97 9.5 3.9 22 5.2 3.9 2.1 1 1 0 1 1 1 0 YyzF-like protein DUF4292 PF14125.6 EPA05847.1 - 0.019 14.7 0.1 0.02 14.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4292) PfkB PF00294.24 EPA05848.1 - 6.3e-12 45.4 0.1 7.8e-11 41.8 0.1 2.0 1 1 0 1 1 1 1 pfkB family carbohydrate kinase HMA PF00403.26 EPA05848.1 - 0.13 12.7 0.2 0.33 11.4 0.1 1.7 2 0 0 2 2 2 0 Heavy-metal-associated domain Glycos_transf_3 PF00591.21 EPA05849.1 - 3.8e-78 262.6 1.1 5.4e-78 262.1 1.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 EPA05849.1 - 5.5e-09 35.8 0.0 1.2e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Nitroreductase PF00881.24 EPA05850.1 - 4.7e-24 85.4 0.2 1.3e-12 48.1 0.0 2.2 1 1 1 2 2 2 2 Nitroreductase family TM1586_NiRdase PF14512.6 EPA05850.1 - 3.4e-10 39.8 0.7 9e-05 22.1 0.0 3.1 2 1 1 3 3 3 3 Putative TM nitroreductase DUF1157 PF06636.11 EPA05850.1 - 0.065 12.0 0.0 0.099 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1157) Aldo_ket_red PF00248.21 EPA05852.1 - 5.9e-56 189.8 0.0 6.7e-56 189.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family IGPS PF00218.21 EPA05853.1 - 1.8e-70 237.0 0.8 2.1e-70 236.8 0.8 1.0 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase QRPTase_C PF01729.19 EPA05853.1 - 5e-06 26.4 0.0 1.1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain NanE PF04131.14 EPA05853.1 - 0.00033 19.9 0.1 0.00084 18.6 0.1 1.8 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase FMN_dh PF01070.18 EPA05853.1 - 0.00069 18.7 0.0 0.012 14.6 0.0 2.0 2 0 0 2 2 2 1 FMN-dependent dehydrogenase DHO_dh PF01180.21 EPA05853.1 - 0.0048 16.1 0.4 0.17 11.0 0.0 2.3 2 1 1 3 3 3 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 EPA05853.1 - 0.0087 15.5 0.0 0.018 14.5 0.0 1.6 1 0 0 1 1 1 1 Histidine biosynthesis protein Cellulase PF00150.18 EPA05853.1 - 0.016 14.7 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) ThiG PF05690.14 EPA05853.1 - 0.063 12.6 0.0 0.15 11.3 0.0 1.6 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG AP_endonuc_2 PF01261.24 EPA05853.1 - 0.078 12.4 0.0 0.2 11.1 0.0 1.6 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel Rad50_zn_hook PF04423.14 EPA05854.1 - 0.11 12.4 0.5 0.16 11.8 0.5 1.3 1 0 0 1 1 1 0 Rad50 zinc hook motif Kazal_1 PF00050.21 EPA05855.1 - 2e-11 43.7 0.3 4.2e-11 42.7 0.3 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EPA05855.1 - 3.6e-07 30.2 0.3 6.5e-07 29.4 0.3 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain HEAT_2 PF13646.6 EPA05856.1 - 0.0016 18.7 0.0 0.0016 18.7 0.0 1.1 1 0 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.6 EPA05856.1 - 0.0055 17.2 0.0 0.0069 16.9 0.0 1.2 1 0 0 1 1 1 1 HEAT-like repeat HEAT PF02985.22 EPA05856.1 - 0.0076 16.4 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 HEAT repeat Cnd1 PF12717.7 EPA05856.1 - 0.012 15.6 0.0 0.012 15.6 0.0 1.0 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 CBS PF00571.28 EPA05857.1 - 2.6e-42 143.1 4.1 4.3e-11 43.1 0.0 4.2 4 0 0 4 4 4 4 CBS domain PduV-EutP PF10662.9 EPA05857.1 - 8.4 6.1 8.8 6.3 6.5 0.1 3.7 3 1 1 4 4 4 0 Ethanolamine utilisation - propanediol utilisation EamA PF00892.20 EPA05858.1 - 3.4e-15 56.4 10.9 3.9e-15 56.2 10.9 1.0 1 0 0 1 1 1 1 EamA-like transporter family DUF1097 PF06496.11 EPA05858.1 - 0.013 15.7 10.9 0.022 14.9 10.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1097) DMT_6 PF04342.12 EPA05858.1 - 0.065 13.4 6.1 0.15 12.3 1.6 2.2 1 1 1 2 2 2 0 Putative member of DMT superfamily (DUF486) CRT-like PF08627.10 EPA05858.1 - 0.098 11.6 6.5 0.11 11.4 6.5 1.2 1 0 0 1 1 1 0 CRT-like, chloroquine-resistance transporter-like PAPS_reduct PF01507.19 EPA05860.1 - 0.075 13.1 0.1 0.075 13.1 0.1 1.0 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family HTH_AsnC-type PF13404.6 EPA05861.1 - 0.00017 21.4 3.7 0.00053 19.8 3.7 1.8 1 1 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 EPA05861.1 - 0.00035 20.1 3.1 0.059 12.9 0.6 2.4 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding Ribosomal_L37e PF01907.19 EPA05863.1 - 0.03 14.5 0.1 0.47 10.6 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L37e tRNA_synthFbeta PF17759.1 EPA05865.1 - 3.6e-39 134.4 0.0 1.3e-38 132.6 0.0 1.7 2 0 0 2 2 2 1 Phenylalanyl tRNA synthetase beta chain CLM domain B5 PF03484.15 EPA05865.1 - 3.1e-18 65.8 0.0 1.6e-11 44.3 0.0 3.3 3 0 0 3 3 3 2 tRNA synthetase B5 domain B3_4 PF03483.17 EPA05865.1 - 2.7e-12 46.7 0.3 4.8e-12 45.9 0.3 1.3 1 0 0 1 1 1 1 B3/4 domain DUF3215 PF11503.8 EPA05865.1 - 0.079 12.8 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3215) EVE PF01878.18 EPA05867.1 - 3.8e-40 137.2 0.4 4.3e-40 137.1 0.4 1.0 1 0 0 1 1 1 1 EVE domain SOR_SNZ PF01680.17 EPA05868.1 - 1.6e-98 328.6 3.2 2.1e-98 328.2 3.2 1.2 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EPA05868.1 - 3.3e-07 29.9 1.4 1.3e-05 24.6 0.1 2.3 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 EPA05868.1 - 5.6e-05 22.7 0.4 0.013 15.0 0.0 3.1 2 1 0 2 2 2 1 Histidine biosynthesis protein Dus PF01207.17 EPA05868.1 - 0.0012 18.0 0.3 1.2 8.1 0.0 2.2 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) IGPS PF00218.21 EPA05868.1 - 0.0024 17.1 0.0 0.05 12.8 0.0 2.3 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase NMO PF03060.15 EPA05868.1 - 0.0024 17.3 5.3 0.15 11.4 0.1 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase OMPdecase PF00215.24 EPA05868.1 - 0.0086 15.7 0.4 1.1 8.9 0.1 2.5 2 1 0 2 2 2 1 Orotidine 5'-phosphate decarboxylase / HUMPS family NanE PF04131.14 EPA05868.1 - 0.018 14.2 3.0 0.7 9.0 0.0 3.3 2 2 1 3 3 3 0 Putative N-acetylmannosamine-6-phosphate epimerase F-box-like_2 PF13013.6 EPA05869.1 - 0.039 13.9 0.1 0.48 10.4 0.1 2.1 1 1 0 1 1 1 0 F-box-like domain tRNA-synt_2d PF01409.20 EPA05870.1 - 1.2e-82 277.1 0.0 2e-82 276.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA_synthFbeta PF17759.1 EPA05870.1 - 3.6e-06 26.6 0.0 0.00049 19.6 0.0 2.3 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain PheRS_DBD3 PF18553.1 EPA05870.1 - 0.0067 16.7 0.0 0.02 15.2 0.0 1.8 1 0 0 1 1 1 1 PheRS DNA binding domain 3 tRNA-synt_2 PF00152.20 EPA05870.1 - 0.0082 15.3 0.1 0.029 13.5 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 EPA05870.1 - 0.013 15.4 0.0 0.039 13.9 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) HTH_9 PF08221.11 EPA05870.1 - 0.18 11.9 0.0 0.48 10.6 0.0 1.8 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain AsnC_trans_reg PF01037.21 EPA05871.1 - 5.3e-11 42.3 0.0 6.1e-11 42.1 0.0 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 EPA05871.1 - 0.0019 18.2 0.0 0.0022 18.0 0.0 1.1 1 0 0 1 1 1 1 NapD protein Aconitase PF00330.20 EPA05872.1 - 2.9e-146 488.1 0.0 5.5e-146 487.2 0.0 1.4 2 0 0 2 2 2 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EPA05872.1 - 4.3e-35 120.9 0.1 1.6e-34 119.1 0.0 2.0 2 0 0 2 2 2 1 Aconitase C-terminal domain DUF521 PF04412.13 EPA05872.1 - 0.032 13.0 0.0 0.052 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) tRNA-synt_1b PF00579.25 EPA05873.1 - 5.4e-29 101.4 0.0 8.7e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1f PF01921.18 EPA05873.1 - 0.051 12.5 0.2 0.46 9.3 0.0 2.1 1 1 1 2 2 2 0 tRNA synthetases class I (K) SNO PF01174.19 EPA05875.1 - 7.1e-50 169.5 0.1 8.1e-50 169.3 0.1 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 EPA05875.1 - 1.8e-12 47.3 0.0 2.5e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 EPA05875.1 - 2.1e-11 43.9 0.0 2.7e-10 40.3 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EPA05875.1 - 6.1e-07 29.4 0.0 1.8e-05 24.6 0.0 2.6 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 EPA05875.1 - 1.8e-06 27.8 0.0 3.1e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family Peptidase_S51 PF03575.17 EPA05875.1 - 3e-06 27.0 0.1 4.2e-06 26.6 0.1 1.2 1 0 0 1 1 1 1 Peptidase family S51 DUF2315 PF10231.9 EPA05876.1 - 0.0017 18.5 0.2 0.0018 18.4 0.2 1.1 1 0 0 1 1 1 1 Apoptogenic protein 1 Baculo_PEP_C PF04513.12 EPA05877.1 - 0.014 15.5 1.5 0.032 14.3 1.5 1.6 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 EPA05877.1 - 0.041 13.9 0.1 0.086 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 EPA05877.1 - 0.071 13.4 0.4 0.17 12.2 0.4 1.6 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Filamin PF00630.19 EPA05877.1 - 0.085 13.7 0.0 0.26 12.1 0.0 1.8 2 1 0 2 2 2 0 Filamin/ABP280 repeat NPV_P10 PF05531.12 EPA05877.1 - 0.35 11.4 2.2 25 5.4 0.2 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 EPA05877.1 - 1.3 9.5 4.6 3.5 8.1 2.0 2.7 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Hydrolase PF00702.26 EPA05879.1 - 7.3e-10 39.5 0.5 1.6e-09 38.4 0.2 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EPA05879.1 - 0.00042 20.1 0.3 0.00052 19.8 0.3 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Usp PF00582.26 EPA05880.1 - 3.2e-30 105.5 0.0 3.5e-30 105.3 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family AA_permease_2 PF13520.6 EPA05881.1 - 3.6e-54 184.2 54.3 4.4e-54 183.9 54.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EPA05881.1 - 2.7e-35 121.9 48.5 3.5e-35 121.5 48.5 1.1 1 0 0 1 1 1 1 Amino acid permease Spore_permease PF03845.13 EPA05881.1 - 0.0011 17.9 25.6 0.0011 17.9 25.6 2.4 2 1 0 2 2 2 2 Spore germination protein MOFRL PF05161.13 EPA05882.1 - 7.6e-06 26.1 0.0 7.6e-06 26.1 0.0 1.0 1 0 0 1 1 1 1 MOFRL family DUF4940 PF16298.5 EPA05882.1 - 0.021 14.5 0.3 0.021 14.5 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4940) FlxA PF14282.6 EPA05883.1 - 0.075 13.0 0.8 2.1 8.4 0.2 2.1 2 0 0 2 2 2 0 FlxA-like protein NPV_P10 PF05531.12 EPA05883.1 - 0.2 12.2 2.1 2.8 8.4 0.1 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein GATase_3 PF07685.14 EPA05884.1 - 0.0003 20.4 0.0 0.00033 20.3 0.0 1.1 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain CbiC PF02570.15 EPA05885.1 - 2e-34 119.0 0.4 2.2e-34 118.9 0.4 1.0 1 0 0 1 1 1 1 Precorrin-8X methylmutase DUF4958 PF16319.5 EPA05885.1 - 0.045 11.7 0.0 0.047 11.7 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4958) CbiC PF02570.15 EPA05886.1 - 2.7e-13 50.0 0.5 2.9e-13 49.9 0.5 1.0 1 0 0 1 1 1 1 Precorrin-8X methylmutase CbiX PF01903.17 EPA05887.1 - 4.7e-17 62.3 0.0 6.1e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 CbiX CbiK PF06180.11 EPA05887.1 - 1.6e-06 27.7 0.2 1.8e-06 27.5 0.2 1.0 1 0 0 1 1 1 1 Cobalt chelatase (CbiK) Ferrochelatase PF00762.19 EPA05887.1 - 0.036 13.1 0.1 0.14 11.2 0.1 1.7 1 1 1 2 2 2 0 Ferrochelatase GATase_3 PF07685.14 EPA05888.1 - 2e-17 63.5 0.2 2.1e-17 63.4 0.2 1.0 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DUF1836 PF08876.11 EPA05888.1 - 0.01 15.9 0.6 0.014 15.4 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1836) CAP_assoc_N PF14504.6 EPA05890.1 - 0.06 13.1 0.0 0.06 13.1 0.0 1.0 1 0 0 1 1 1 0 CAP-associated N-terminal tRNA_anti-codon PF01336.25 EPA05891.1 - 1.3e-05 25.1 0.0 0.2 11.7 0.0 2.4 2 0 0 2 2 2 2 OB-fold nucleic acid binding domain POT1PC PF16686.5 EPA05891.1 - 0.021 14.7 0.0 0.47 10.3 0.0 2.2 2 0 0 2 2 2 0 ssDNA-binding domain of telomere protection protein RNA_pol_Rpb1_1 PF04997.12 EPA05891.1 - 0.086 12.2 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 DUF354 PF04007.12 EPA05892.1 - 6.9e-46 156.9 3.3 8e-46 156.6 3.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF354) LpxB PF02684.15 EPA05892.1 - 0.00054 18.9 0.1 0.00076 18.4 0.1 1.3 1 0 0 1 1 1 1 Lipid-A-disaccharide synthetase AAA_12 PF13087.6 EPA05892.1 - 0.046 13.4 0.7 0.066 12.8 0.7 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EPA05893.1 - 5.6e-29 101.4 0.0 9.8e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EPA05893.1 - 2.2e-13 50.7 0.1 5.8e-07 29.6 0.0 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 EPA05893.1 - 5.1e-06 27.1 1.4 1.7e-05 25.5 1.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) AAA_15 PF13175.6 EPA05893.1 - 7.1e-06 26.0 0.1 0.00036 20.4 0.1 3.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EPA05893.1 - 0.006 16.3 0.3 0.012 15.4 0.3 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Mg_chelatase PF01078.21 EPA05893.1 - 0.042 13.2 0.0 0.067 12.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_23 PF13476.6 EPA05893.1 - 0.061 13.8 8.0 0.24 11.9 8.0 2.2 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 EPA05893.1 - 0.078 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 EPA05893.1 - 0.094 12.1 1.0 11 5.4 0.0 2.5 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 EPA05893.1 - 0.15 11.7 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 EPA05893.1 - 1.1 9.3 5.9 7.4 6.6 0.3 2.5 2 1 0 2 2 2 0 Helicase HerA, central domain CDC24_OB3 PF17244.2 EPA05894.1 - 9.1e-06 25.5 0.1 1.8e-05 24.5 0.0 1.5 2 0 0 2 2 2 1 Cell division control protein 24, OB domain 3 tRNA_anti-codon PF01336.25 EPA05894.1 - 1.8e-05 24.6 0.2 0.00082 19.3 0.0 2.6 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain UDPG_MGDP_dh_N PF03721.14 EPA05895.1 - 5.1e-07 29.5 0.5 0.0061 16.1 0.0 2.3 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 EPA05895.1 - 6.4e-06 26.4 0.0 1.3e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain UDPG_MGDP_dh PF00984.19 EPA05895.1 - 0.001 19.2 0.0 0.0024 18.0 0.0 1.7 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_binding_2 PF03446.15 EPA05895.1 - 0.026 14.7 0.0 0.2 11.8 0.0 2.3 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase OKR_DC_1 PF01276.20 EPA05895.1 - 0.034 12.9 0.0 0.048 12.4 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain GDP_Man_Dehyd PF16363.5 EPA05895.1 - 0.056 12.8 0.0 0.098 12.0 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF166 PF02593.14 EPA05895.1 - 0.06 12.9 0.0 0.092 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DEAD PF00270.29 EPA05896.1 - 2.5e-28 99.0 0.1 4.3e-28 98.3 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EPA05896.1 - 1.3e-11 44.8 0.0 1.9e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EPA05896.1 - 2.2e-06 28.0 0.1 0.0027 18.0 0.0 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain SNF2_N PF00176.23 EPA05896.1 - 0.00057 18.7 0.0 0.00079 18.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain SWI2_SNF2 PF18766.1 EPA05896.1 - 0.044 13.5 0.0 0.066 12.9 0.0 1.2 1 0 0 1 1 1 0 SWI2/SNF2 ATPase AAA_19 PF13245.6 EPA05896.1 - 0.068 13.5 0.1 0.16 12.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain OKR_DC_1_N PF03709.15 EPA05896.1 - 0.12 12.7 0.1 0.98 9.7 0.0 2.4 2 1 0 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain DUF3783 PF12646.7 EPA05897.1 - 0.042 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3783) ABC2_membrane PF01061.24 EPA05898.1 - 7.8e-21 74.5 21.2 7.8e-21 74.5 21.2 1.4 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 EPA05898.1 - 4.4e-14 52.3 35.7 1.2e-13 50.9 25.4 2.0 1 1 1 2 2 2 2 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 EPA05898.1 - 0.0036 16.6 19.2 0.0057 16.0 19.2 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein Phage_holin_4_1 PF05105.12 EPA05898.1 - 0.2 11.8 7.4 0.073 13.2 3.5 2.3 1 1 1 2 2 2 0 Bacteriophage holin family ABC2_membrane_4 PF12730.7 EPA05898.1 - 0.38 10.7 17.7 0.02 14.8 10.8 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein DEAD_assoc PF08494.11 EPA05899.1 - 1.9e-26 93.1 0.0 3.9e-26 92.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/H associated Helicase_C PF00271.31 EPA05899.1 - 0.00011 22.5 0.1 0.00042 20.6 0.1 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Secretin_N_2 PF07655.13 EPA05899.1 - 0.34 11.5 3.6 0.62 10.6 3.6 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Ribosomal_L39 PF00832.20 EPA05900.1 - 1.4e-16 59.9 7.7 1.6e-16 59.7 7.7 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein REV PF00424.18 EPA05900.1 - 0.094 12.7 2.6 0.1 12.6 2.6 1.1 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) NUDIX PF00293.28 EPA05901.1 - 2.3e-11 43.8 0.0 2.7e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Ribosomal_L31e PF01198.19 EPA05902.1 - 8.8e-19 67.5 0.3 1.3e-18 67.0 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L31e Rhodanese PF00581.20 EPA05903.1 - 1.1e-30 106.3 0.0 2.9e-18 66.4 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain TPR_2 PF07719.17 EPA05904.1 - 5.1e-21 73.0 3.9 6.7e-07 29.0 0.1 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 EPA05904.1 - 9.6e-20 69.5 5.2 6.4e-07 28.9 0.1 4.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 EPA05904.1 - 4.6e-14 52.7 1.5 1.3e-08 35.2 0.1 2.7 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EPA05904.1 - 1.6e-13 50.0 0.2 0.0014 18.8 0.0 3.8 3 1 1 4 4 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 EPA05904.1 - 5.8e-13 49.2 0.0 0.00049 20.7 0.0 3.0 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EPA05904.1 - 6.3e-13 47.8 6.0 0.00074 19.5 0.1 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EPA05904.1 - 1.8e-12 46.7 6.6 0.00035 20.2 0.2 4.8 3 1 2 5 5 4 3 TPR repeat TPR_14 PF13428.6 EPA05904.1 - 2.3e-11 43.5 0.9 0.0033 18.1 0.0 4.9 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EPA05904.1 - 5.2e-09 36.3 3.6 3.9e-06 27.0 0.2 4.7 2 2 3 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EPA05904.1 - 6.1e-09 36.0 0.2 1.5e-08 34.7 0.2 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 EPA05904.1 - 9.5e-07 28.8 0.2 0.071 13.2 0.0 3.8 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 EPA05904.1 - 1.2e-06 28.5 0.0 0.00051 20.1 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 EPA05904.1 - 5.2e-06 26.8 3.1 5.3 7.9 0.0 4.8 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EPA05904.1 - 5.4e-05 22.9 1.5 5.9 6.9 0.0 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EPA05904.1 - 0.00024 20.9 0.6 22 5.4 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat HTH_27 PF13463.6 EPA05904.1 - 0.00037 20.9 0.3 0.0015 18.9 0.2 2.1 2 0 0 2 2 1 1 Winged helix DNA-binding domain SRP_TPR_like PF17004.5 EPA05904.1 - 0.0004 20.4 1.2 0.00074 19.5 0.5 1.9 2 0 0 2 2 2 1 Putative TPR-like repeat Coatomer_E PF04733.14 EPA05904.1 - 0.0028 17.1 1.1 0.049 13.1 0.2 2.5 1 1 2 3 3 3 1 Coatomer epsilon subunit NARP1 PF12569.8 EPA05904.1 - 0.0073 15.3 3.0 0.14 11.0 0.0 2.5 1 1 2 3 3 3 1 NMDA receptor-regulated protein 1 TPR_20 PF14561.6 EPA05904.1 - 0.012 15.9 0.5 1.6 9.1 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 EPA05904.1 - 0.019 14.9 2.6 7.5 6.7 0.3 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TrmB PF01978.19 EPA05904.1 - 0.032 14.1 0.0 4.6 7.2 0.0 3.0 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB NIR_SIR PF01077.22 EPA05906.1 - 4.4e-42 143.3 0.0 4.1e-32 110.9 0.0 2.2 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 EPA05906.1 - 3.8e-12 45.9 0.0 6.7e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain DUF2666 PF10869.8 EPA05908.1 - 0.0022 18.2 1.3 0.0025 18.0 1.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2666) Vps4_C PF09336.10 EPA05908.1 - 0.039 13.9 0.1 0.064 13.3 0.1 1.4 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain NMD3 PF04981.13 EPA05908.1 - 0.099 12.1 0.4 0.18 11.3 0.4 1.4 1 1 0 1 1 1 0 NMD3 family PHP_C PF13263.6 EPA05909.1 - 1.8e-09 37.2 0.0 5.1e-09 35.7 0.0 1.8 1 0 0 1 1 1 1 PHP-associated PHP PF02811.19 EPA05909.1 - 0.013 15.8 1.3 0.016 15.5 1.3 1.3 1 1 0 1 1 1 0 PHP domain CNPase PF05881.12 EPA05909.1 - 0.027 14.0 0.0 0.064 12.8 0.0 1.6 2 0 0 2 2 2 0 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) Glyco_tranf_2_4 PF13704.6 EPA05909.1 - 0.1 13.1 0.2 0.72 10.4 0.1 2.3 2 1 0 2 2 2 0 Glycosyl transferase family 2 Methyltransf_33 PF10017.9 EPA05910.1 - 4.8e-101 338.0 0.8 5.4e-101 337.8 0.8 1.0 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Methyltransf_23 PF13489.6 EPA05910.1 - 0.01 15.6 0.0 0.13 12.1 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain F420_ligase PF01996.16 EPA05911.1 - 3.9e-56 190.1 1.4 4.8e-56 189.8 1.4 1.0 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase HAD PF12710.7 EPA05912.1 - 5.6e-10 39.9 0.0 6.9e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EPA05912.1 - 9.1e-10 39.2 0.0 1.2e-08 35.5 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EPA05912.1 - 8.5e-05 22.4 0.7 0.00079 19.2 0.5 2.2 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase DS PF01916.17 EPA05913.1 - 1.6e-53 181.8 0.1 1.9e-53 181.6 0.1 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase ABC_tran PF00005.27 EPA05914.1 - 1.1e-33 116.7 0.1 1.5e-33 116.2 0.1 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 EPA05914.1 - 2.3e-17 63.3 0.3 5.4e-17 62.1 0.1 1.7 2 0 0 2 2 1 1 Oligopeptide/dipeptide transporter, C-terminal region SMC_N PF02463.19 EPA05914.1 - 3.1e-05 23.5 0.7 5.4e-05 22.7 0.7 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EPA05914.1 - 8e-05 23.1 0.0 0.00013 22.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EPA05914.1 - 0.00018 21.8 0.7 0.0031 17.8 0.7 2.2 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EPA05914.1 - 0.00034 20.5 0.2 0.00065 19.6 0.2 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA PF00004.29 EPA05914.1 - 0.00066 20.1 0.4 0.012 16.0 0.4 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 EPA05914.1 - 0.001 18.9 0.4 1 9.1 0.1 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EPA05914.1 - 0.0012 18.6 0.1 0.0027 17.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EPA05914.1 - 0.0016 17.8 0.0 0.0027 17.0 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_15 PF13175.6 EPA05914.1 - 0.0019 18.0 0.0 0.0038 17.0 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 EPA05914.1 - 0.0026 16.9 0.0 0.0038 16.3 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein G-alpha PF00503.20 EPA05914.1 - 0.0072 15.5 0.2 0.0095 15.1 0.2 1.2 1 0 0 1 1 1 1 G-protein alpha subunit RNA_helicase PF00910.22 EPA05914.1 - 0.013 15.9 0.0 0.027 14.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 EPA05914.1 - 0.013 15.0 0.1 0.033 13.7 0.1 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region DnaB_C PF03796.15 EPA05914.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Sigma54_activat PF00158.26 EPA05914.1 - 0.014 15.1 0.1 0.032 13.9 0.1 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_18 PF13238.6 EPA05914.1 - 0.017 15.7 0.0 0.032 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EPA05914.1 - 0.018 14.4 0.4 0.11 11.8 0.1 2.1 2 0 0 2 2 2 0 KaiC Phage_TAC_13 PF16459.5 EPA05914.1 - 0.036 14.5 0.1 0.094 13.2 0.1 1.7 1 0 0 1 1 1 0 Phage tail assembly chaperone, TAC DUF87 PF01935.17 EPA05914.1 - 0.039 14.0 1.8 0.054 13.6 0.3 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain Membralin PF09746.9 EPA05914.1 - 0.047 12.7 0.1 0.063 12.3 0.1 1.1 1 0 0 1 1 1 0 Tumour-associated protein IstB_IS21 PF01695.17 EPA05914.1 - 0.05 13.3 0.1 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein ATP-synt_ab PF00006.25 EPA05914.1 - 0.055 13.1 0.0 0.082 12.6 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_5 PF07728.14 EPA05914.1 - 0.085 12.9 0.0 0.28 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 EPA05914.1 - 0.094 12.7 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE APS_kinase PF01583.20 EPA05914.1 - 0.097 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_30 PF13604.6 EPA05914.1 - 0.11 12.2 0.0 0.26 11.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EPA05914.1 - 0.12 11.7 0.2 0.24 10.7 0.0 1.5 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EPA05914.1 - 0.13 12.4 0.0 0.52 10.5 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EPA05914.1 - 0.29 11.6 5.7 2.9 8.3 5.7 2.3 1 1 0 1 1 1 0 AAA domain tRNA-synt_2b PF00587.25 EPA05917.1 - 1.9e-18 67.1 0.0 3.1e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EPA05917.1 - 1.4e-16 60.4 0.2 1.4e-16 60.4 0.2 2.1 2 0 0 2 2 2 1 Anticodon binding domain DUF4462 PF14692.6 EPA05918.1 - 0.39 10.2 0.4 0.39 10.2 0.4 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4462) LysE PF01810.18 EPA05919.1 - 3.5e-31 108.2 15.5 4.5e-31 107.8 15.5 1.0 1 0 0 1 1 1 1 LysE type translocator TNFR_16_TM PF18422.1 EPA05919.1 - 0.075 13.0 0.5 0.23 11.4 0.5 1.8 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain GWT1 PF06423.12 EPA05919.1 - 1.4 9.1 6.7 5.2 7.2 6.7 1.9 1 1 0 1 1 1 0 GWT1 Inos-1-P_synth PF01658.17 EPA05920.1 - 6.7e-30 103.5 0.4 2.2e-28 98.6 0.0 2.2 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase RexA PF15969.5 EPA05920.1 - 0.041 13.4 0.1 0.85 9.1 0.0 2.2 2 0 0 2 2 2 0 Intracellular sensor of Lambda phage, Abi component CobU PF02283.16 EPA05920.1 - 0.057 13.0 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Raco_middle PF17651.1 EPA05920.1 - 0.17 11.6 0.1 9.3 5.9 0.0 2.7 2 1 1 3 3 3 0 RACo middle region PAC2 PF09754.9 EPA05921.1 - 3.5e-22 79.5 0.0 4.4e-22 79.1 0.0 1.0 1 0 0 1 1 1 1 PAC2 family VGLL4 PF15245.6 EPA05923.1 - 0.24 11.5 4.6 0.24 11.4 4.6 1.0 1 0 0 1 1 1 0 Transcription cofactor vestigial-like protein 4 SMC_N PF02463.19 EPA05924.1 - 1.6e-55 187.9 33.6 1.1e-32 113.3 0.1 3.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EPA05924.1 - 2.3e-18 66.6 0.0 1e-17 64.5 0.0 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EPA05924.1 - 3e-09 37.1 25.0 9.6e-06 25.6 4.2 4.7 2 2 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EPA05924.1 - 3.9e-07 30.1 25.8 3.9e-07 30.1 25.8 4.4 2 2 1 3 3 2 1 AAA ATPase domain AAA_23 PF13476.6 EPA05924.1 - 4.2e-06 27.4 120.4 0.0002 21.9 63.2 7.3 2 2 0 3 3 2 1 AAA domain AAA_29 PF13555.6 EPA05924.1 - 4.4e-06 26.3 0.0 1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Tubulin_3 PF14881.6 EPA05924.1 - 0.0016 18.2 0.1 0.0097 15.6 0.1 2.4 1 0 0 1 1 1 1 Tubulin domain ATG16 PF08614.11 EPA05924.1 - 0.0064 16.7 7.7 0.0064 16.7 7.7 6.8 2 2 4 6 6 6 3 Autophagy protein 16 (ATG16) SbcCD_C PF13558.6 EPA05924.1 - 0.051 13.8 0.2 0.35 11.1 0.0 2.6 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit APG6_N PF17675.1 EPA05924.1 - 0.73 10.4 113.5 0.08 13.5 11.5 9.0 3 2 6 9 9 9 0 Apg6 coiled-coil region CT_C_D PF02682.16 EPA05924.1 - 1.9 8.2 4.0 9.3 5.9 0.0 3.3 3 0 0 3 3 3 0 Carboxyltransferase domain, subdomain C and D DS PF01916.17 EPA05925.1 - 1.5e-07 31.0 0.0 1.6e-07 30.9 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Alba PF01918.21 EPA05926.1 - 5.9e-13 48.4 1.3 7.7e-13 48.1 1.3 1.2 1 0 0 1 1 1 1 Alba Methyltrn_RNA_3 PF02598.17 EPA05926.1 - 0.019 14.5 0.6 0.02 14.4 0.6 1.0 1 0 0 1 1 1 0 Putative RNA methyltransferase FGE-sulfatase PF03781.16 EPA05927.1 - 2.7e-41 141.9 5.3 4.7e-41 141.1 5.3 1.3 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 EPA05927.1 - 3.9e-08 33.8 0.0 1.7e-07 31.8 0.0 2.1 2 1 0 2 2 2 1 DinB superfamily DinB PF05163.12 EPA05927.1 - 0.088 12.7 0.2 0.27 11.1 0.2 1.9 1 1 0 1 1 1 0 DinB family E3_UbLigase_R4 PF13764.6 EPA05927.1 - 0.26 9.4 1.0 0.42 8.7 1.0 1.2 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 Prok-JAB PF14464.6 EPA05928.1 - 5.9e-20 71.2 0.0 6.7e-20 71.0 0.0 1.0 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain JAB PF01398.21 EPA05928.1 - 5.8e-07 29.5 0.0 7.5e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RadC PF04002.15 EPA05928.1 - 0.00012 22.0 0.2 0.00024 21.1 0.2 1.4 1 1 0 1 1 1 1 RadC-like JAB domain Toxin-JAB1 PF15659.6 EPA05928.1 - 0.0024 18.2 0.3 0.035 14.4 0.1 2.1 1 1 1 2 2 2 1 JAB-like toxin 1 TylF PF05711.11 EPA05928.1 - 0.052 12.8 0.0 0.087 12.1 0.0 1.4 1 1 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) Sda PF08970.10 EPA05928.1 - 0.06 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Sporulation inhibitor A UbiA PF01040.18 EPA05929.1 - 2e-50 171.5 22.5 2.6e-50 171.1 22.5 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF1129 PF06570.11 EPA05929.1 - 1.5 8.3 9.2 2.8 7.4 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) DUF2024 PF09630.10 EPA05930.1 - 2.9e-37 126.4 1.7 3.2e-37 126.3 1.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2024) Haem_bd PF14376.6 EPA05930.1 - 0.036 14.0 0.1 0.04 13.9 0.1 1.1 1 0 0 1 1 1 0 Haem-binding domain DUF108 PF01958.18 EPA05932.1 - 1.4e-32 111.9 1.1 2.3e-32 111.2 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF108 NAD_binding_3 PF03447.16 EPA05932.1 - 1.8e-08 35.1 0.1 3.7e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DUF1610 PF07754.11 EPA05933.1 - 5.3e-05 23.1 9.5 5.3e-05 23.1 9.5 3.0 4 0 0 4 4 4 2 Domain of unknown function (DUF1610) zf-CHY PF05495.12 EPA05933.1 - 0.037 14.5 17.1 0.042 14.3 17.1 1.2 1 0 0 1 1 1 0 CHY zinc finger zf-ribbon_3 PF13248.6 EPA05933.1 - 0.058 12.8 0.2 0.058 12.8 0.2 3.7 4 1 0 4 4 4 0 zinc-ribbon domain NadA PF02445.16 EPA05934.1 - 5.7e-113 377.0 1.8 6.5e-113 376.8 1.8 1.0 1 0 0 1 1 1 1 Quinolinate synthetase A protein Methyltransf_3 PF01596.17 EPA05935.1 - 7.3e-37 126.6 0.8 1.6e-36 125.5 0.8 1.6 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EPA05935.1 - 2e-13 51.3 0.0 3.6e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EPA05935.1 - 8.4e-08 32.2 0.1 3.7e-07 30.1 0.1 1.9 2 1 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EPA05935.1 - 4.5e-06 26.5 0.1 7.1e-06 25.9 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 EPA05935.1 - 2.8e-05 23.9 0.0 3.7e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_25 PF13649.6 EPA05935.1 - 5.3e-05 23.8 0.0 0.00016 22.3 0.0 1.8 3 0 0 3 3 2 1 Methyltransferase domain CMAS PF02353.20 EPA05935.1 - 0.00015 21.1 0.1 0.00019 20.9 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Cons_hypoth95 PF03602.15 EPA05935.1 - 0.00031 20.4 0.0 0.00048 19.8 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 EPA05935.1 - 0.00065 19.3 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltr_RsmB-F PF01189.17 EPA05935.1 - 0.0023 17.6 0.0 0.004 16.8 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F GCD14 PF08704.10 EPA05935.1 - 0.038 13.7 0.0 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit UPF0020 PF01170.18 EPA05935.1 - 0.038 13.7 0.0 0.064 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 TRM PF02005.16 EPA05935.1 - 0.05 12.8 0.0 0.069 12.3 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_23 PF13489.6 EPA05935.1 - 0.052 13.4 0.0 0.067 13.0 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain PTH2 PF01981.16 EPA05936.1 - 4.1e-40 136.7 0.0 4.6e-40 136.6 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Pro_dh PF01619.18 EPA05937.1 - 7.6e-25 88.1 0.0 1.1e-24 87.5 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase Peptidase_M15_2 PF05951.13 EPA05937.1 - 0.068 12.8 0.4 0.22 11.2 0.1 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF882) Telomere_reg-2 PF10193.9 EPA05937.1 - 0.15 12.5 0.0 0.64 10.5 0.0 1.9 2 0 0 2 2 2 0 Telomere length regulation protein NAD_binding_8 PF13450.6 EPA05938.1 - 0.0021 18.3 0.1 0.0044 17.2 0.1 1.6 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EPA05938.1 - 0.0034 16.2 0.8 0.011 14.5 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 EPA05938.1 - 0.013 14.7 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EPA05938.1 - 0.014 14.7 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 EPA05938.1 - 0.015 14.4 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Amino_oxidase PF01593.24 EPA05938.1 - 0.023 14.0 0.0 0.039 13.2 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 EPA05938.1 - 0.027 13.8 0.3 0.042 13.2 0.2 1.3 1 1 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EPA05938.1 - 0.19 10.7 0.0 0.21 10.6 0.0 1.0 1 0 0 1 1 1 0 Lycopene cyclase protein SprT-like PF10263.9 EPA05939.1 - 0.0015 18.4 0.2 0.0024 17.7 0.2 1.4 1 1 0 1 1 1 1 SprT-like family DUF45 PF01863.17 EPA05939.1 - 0.011 15.8 0.0 0.025 14.6 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function DUF45 Peptidase_M76 PF09768.9 EPA05939.1 - 0.032 14.0 0.0 0.035 13.9 0.0 1.1 1 0 0 1 1 1 0 Peptidase M76 family H_PPase PF03030.16 EPA05940.1 - 1.3e-221 737.7 50.8 1.5e-221 737.6 50.8 1.0 1 0 0 1 1 1 1 Inorganic H+ pyrophosphatase Cu-oxidase_3 PF07732.15 EPA05942.1 - 2.7e-43 146.8 1.1 1.7e-34 118.3 0.0 2.3 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EPA05942.1 - 5.1e-33 113.7 1.1 6.9e-24 84.1 0.7 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EPA05942.1 - 7.8e-17 61.8 0.0 3.5e-16 59.7 0.0 1.9 2 1 0 2 2 2 1 Multicopper oxidase Cupredoxin_1 PF13473.6 EPA05942.1 - 2.9e-16 59.4 0.8 2.1e-10 40.6 0.1 4.0 3 2 0 3 3 3 3 Cupredoxin-like domain Copper-bind PF00127.20 EPA05942.1 - 4.7e-08 33.4 0.3 0.0019 18.6 0.1 3.5 3 1 0 3 3 3 2 Copper binding proteins, plastocyanin/azurin family SoxE PF06525.11 EPA05942.1 - 3.2e-05 23.4 0.1 0.0014 18.1 0.0 2.7 2 1 0 2 2 2 1 Sulfocyanin (SoxE) domain DUF2310 PF10071.9 EPA05942.1 - 0.21 10.8 0.0 0.43 9.8 0.0 1.4 1 0 0 1 1 1 0 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) RPAP1_N PF08621.10 EPA05942.1 - 3.9 7.3 5.3 0.32 10.8 0.4 1.6 2 0 0 2 2 2 0 RPAP1-like, N-terminal DUF359 PF04019.12 EPA05943.1 - 5.2e-34 116.6 0.0 8.4e-34 115.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF359) TruD PF01142.18 EPA05944.1 - 2.4e-24 85.9 0.4 2.6e-24 85.8 0.4 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) QRPTase_C PF01729.19 EPA05946.1 - 8e-56 188.4 1.1 8.9e-56 188.3 1.1 1.0 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain Ribul_P_3_epim PF00834.19 EPA05946.1 - 0.0077 15.6 0.2 0.015 14.7 0.1 1.5 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family Glu_synthase PF01645.17 EPA05946.1 - 0.018 14.2 0.1 0.12 11.5 0.0 2.0 2 0 0 2 2 2 0 Conserved region in glutamate synthase AAA_5 PF07728.14 EPA05946.1 - 0.041 13.9 0.1 0.093 12.7 0.1 1.6 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) Ssl1 PF04056.14 EPA05946.1 - 0.087 12.6 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Ssl1-like Spt4 PF06093.13 EPA05947.1 - 1.5e-13 50.7 0.5 1.8e-13 50.4 0.5 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger RecR PF02132.15 EPA05947.1 - 0.0029 17.2 0.7 0.0035 16.9 0.7 1.1 1 0 0 1 1 1 1 RecR protein SGL PF08450.12 EPA05948.1 - 1.2e-09 38.2 0.9 0.16 11.5 0.0 4.2 2 2 2 4 4 4 4 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EPA05948.1 - 8.6e-06 25.5 0.0 0.00053 19.9 0.0 2.9 2 0 0 2 2 2 1 NHL repeat DUF5074 PF16819.5 EPA05948.1 - 2.6e-05 24.2 0.7 2.1 8.4 0.1 3.7 3 1 0 3 3 3 2 Domain of unknown function (DUF5074) Reg_prop PF07494.11 EPA05948.1 - 0.0054 16.8 3.9 18 6.0 0.0 4.6 4 0 0 4 4 4 1 Two component regulator propeller Str_synth PF03088.16 EPA05948.1 - 0.0059 16.7 0.0 12 6.1 0.0 4.0 3 1 1 4 4 4 1 Strictosidine synthase Phytase-like PF13449.6 EPA05948.1 - 0.0063 16.5 0.1 1 9.2 0.0 2.4 1 1 0 2 2 2 1 Esterase-like activity of phytase Biotin_lipoyl_2 PF13533.6 EPA05948.1 - 0.23 11.3 0.0 1.5 8.7 0.0 2.3 2 0 0 2 2 2 0 Biotin-lipoyl like Copper-bind PF00127.20 EPA05949.1 - 8.1e-16 58.3 0.6 8.8e-08 32.5 0.1 2.7 2 1 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 EPA05949.1 - 1.2e-12 47.9 0.1 1.3e-06 28.5 0.0 2.4 2 0 0 2 2 2 2 Cupredoxin-like domain TPR_1 PF00515.28 EPA05950.1 - 2.7e-13 49.1 1.1 4.6e-05 23.1 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EPA05950.1 - 9.1e-12 44.1 0.0 0.00021 21.2 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EPA05950.1 - 1.3e-10 40.6 1.6 0.00011 22.1 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EPA05950.1 - 2.5e-10 40.7 0.0 5.8e-08 33.1 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EPA05950.1 - 9.5e-09 35.4 0.1 1.2e-08 35.0 0.1 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EPA05950.1 - 3.3e-06 27.3 0.0 0.0047 17.2 0.0 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EPA05950.1 - 4.1e-05 23.3 0.0 0.05 13.6 0.0 2.5 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EPA05950.1 - 4.4e-05 24.0 0.0 6.7e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 EPA05950.1 - 0.00013 22.1 0.2 0.05 14.0 0.0 3.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EPA05950.1 - 0.00034 21.1 0.0 0.22 12.2 0.0 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EPA05950.1 - 0.0012 18.9 0.7 1.1 9.4 0.0 3.1 1 1 2 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat DUF4919 PF16266.5 EPA05950.1 - 0.0015 18.5 1.3 0.033 14.1 0.6 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4919) SRP_TPR_like PF17004.5 EPA05950.1 - 0.022 14.8 0.8 0.089 12.8 0.4 1.8 1 1 1 2 2 2 0 Putative TPR-like repeat TPR_3 PF07720.12 EPA05950.1 - 0.023 14.7 4.8 0.046 13.7 0.3 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EPA05950.1 - 0.026 15.3 0.0 18 6.5 0.0 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat ChAPs PF09295.10 EPA05950.1 - 0.029 13.4 0.1 0.032 13.3 0.1 1.1 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) DUF4284 PF14112.6 EPA05950.1 - 0.044 14.7 0.7 0.17 12.8 0.2 2.0 1 1 1 2 2 2 0 Immunity protein 22 DXP_reductoisom PF02670.16 EPA05950.1 - 0.057 14.1 0.0 0.1 13.3 0.0 1.4 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Rapsyn_N PF10579.9 EPA05950.1 - 0.072 13.2 0.5 1.6 8.8 0.2 2.1 1 1 1 2 2 2 0 Rapsyn N-terminal myristoylation and linker region FIVAR PF07554.13 EPA05950.1 - 0.32 11.8 4.8 0.74 10.6 0.4 2.9 3 0 0 3 3 3 0 FIVAR domain TPR_11 PF13414.6 EPA05950.1 - 0.46 10.2 2.5 3.1 7.5 0.4 2.8 2 1 1 3 3 3 0 TPR repeat alpha-hel2 PF14456.6 EPA05951.1 - 0.012 14.9 0.0 0.017 14.5 0.0 1.1 1 0 0 1 1 1 0 Alpha-helical domain 2 EF1_GNE PF00736.19 EPA05952.1 - 8.1e-19 67.6 0.2 9.1e-19 67.4 0.2 1.0 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain BofC_C PF08955.10 EPA05952.1 - 0.1 12.6 0.1 0.27 11.3 0.1 1.6 2 0 0 2 2 2 0 BofC C-terminal domain Cyclophil_like PF04126.13 EPA05953.1 - 1.2e-37 128.4 0.0 1.5e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin-like Cyclophil_like2 PF18050.1 EPA05953.1 - 8.3e-08 32.2 0.0 1e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin-like family NSP2_assoc PF14758.6 EPA05953.1 - 0.18 12.1 0.0 0.23 11.8 0.0 1.1 1 0 0 1 1 1 0 Non-essential region of nsp2 of arterivirus polyprotein ParA PF10609.9 EPA05954.1 - 2.1e-99 331.9 0.2 2.8e-99 331.5 0.2 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase FeS_assembly_P PF01883.19 EPA05954.1 - 5.4e-18 64.9 0.1 1.9e-17 63.2 0.1 2.0 2 0 0 2 2 2 1 Iron-sulfur cluster assembly protein CbiA PF01656.23 EPA05954.1 - 1.2e-13 51.2 0.0 5.5e-13 49.1 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EPA05954.1 - 1.1e-09 38.5 1.5 9.2e-08 32.2 0.8 2.3 1 1 1 2 2 2 1 AAA domain MipZ PF09140.11 EPA05954.1 - 8e-08 31.9 0.0 1.3e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ AAA_26 PF13500.6 EPA05954.1 - 7.9e-07 29.1 0.8 0.0073 16.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain ArsA_ATPase PF02374.15 EPA05954.1 - 6.7e-06 25.5 0.8 3.1e-05 23.3 0.7 2.0 2 0 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 EPA05954.1 - 9.4e-06 25.3 0.2 0.00047 19.7 0.1 2.3 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family VirC1 PF07015.11 EPA05954.1 - 0.0024 17.2 0.0 0.0062 15.9 0.0 1.7 1 0 0 1 1 1 1 VirC1 protein CLP1_P PF16575.5 EPA05954.1 - 0.0035 17.1 0.0 0.0078 16.0 0.0 1.6 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CBP_BcsQ PF06564.12 EPA05954.1 - 0.0038 16.7 0.1 0.017 14.6 0.1 1.9 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ MeaB PF03308.16 EPA05954.1 - 0.018 14.1 0.4 0.028 13.4 0.4 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 EPA05954.1 - 0.026 14.1 0.7 0.053 13.1 0.7 1.4 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 EPA05954.1 - 0.087 12.7 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase QRPTase_N PF02749.16 EPA05955.1 - 8.5e-19 67.4 0.1 1.1e-18 67.1 0.1 1.0 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain Ufm1 PF03671.14 EPA05955.1 - 0.0004 20.4 0.1 0.00047 20.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein Ppx-GppA PF02541.16 EPA05955.1 - 0.085 12.3 0.0 0.085 12.3 0.0 1.1 1 0 0 1 1 1 0 Ppx/GppA phosphatase family AAA PF00004.29 EPA05956.1 - 1.9e-91 303.4 0.1 5e-48 162.9 0.0 3.1 4 0 0 4 4 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EPA05956.1 - 4.9e-32 109.5 3.6 3.5e-15 55.5 0.1 2.6 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EPA05956.1 - 1.6e-27 95.5 0.8 6.2e-27 93.6 0.8 2.1 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 EPA05956.1 - 1.2e-15 57.6 1.3 1.1e-08 35.0 0.0 3.5 3 1 2 5 5 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EPA05956.1 - 3.6e-13 50.0 0.0 1.4e-07 31.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EPA05956.1 - 1.2e-12 48.5 0.2 0.0032 17.9 0.0 4.8 2 2 2 4 4 4 2 AAA ATPase domain AAA_14 PF13173.6 EPA05956.1 - 1e-11 45.0 0.0 3.7e-06 27.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EPA05956.1 - 1.2e-10 41.6 0.4 0.00038 20.5 0.0 4.5 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EPA05956.1 - 1.9e-10 41.1 0.1 0.03 14.6 0.0 4.4 3 1 1 4 4 4 2 AAA domain RNA_helicase PF00910.22 EPA05956.1 - 1.7e-09 38.0 0.0 0.0017 18.7 0.0 3.0 3 0 0 3 3 2 2 RNA helicase CDC48_2 PF02933.17 EPA05956.1 - 2.6e-09 36.7 0.2 1.1e-08 34.8 0.1 2.0 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 ATPase_2 PF01637.18 EPA05956.1 - 9.5e-09 35.5 0.0 0.0041 17.1 0.0 3.5 2 1 1 3 3 3 2 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EPA05956.1 - 1.2e-08 34.7 1.0 0.22 11.0 0.0 4.8 5 1 1 6 6 5 2 AAA domain ABC_tran PF00005.27 EPA05956.1 - 2e-08 34.9 0.1 0.011 16.3 0.0 3.5 2 1 0 2 2 2 2 ABC transporter AAA_33 PF13671.6 EPA05956.1 - 2.3e-08 34.3 0.0 0.0041 17.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EPA05956.1 - 2.5e-08 34.5 0.0 0.0042 17.6 0.0 3.0 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 EPA05956.1 - 1.1e-07 32.0 0.4 0.03 14.3 0.0 3.3 2 2 0 2 2 2 2 Rad17 P-loop domain AAA_24 PF13479.6 EPA05956.1 - 7.2e-07 29.1 0.1 0.11 12.2 0.0 3.7 3 1 0 3 3 3 2 AAA domain Mg_chelatase PF01078.21 EPA05956.1 - 8e-07 28.6 0.4 0.018 14.4 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EPA05956.1 - 8.3e-07 29.4 0.0 0.077 13.2 0.0 2.7 3 0 0 3 3 2 2 AAA domain Sigma54_activ_2 PF14532.6 EPA05956.1 - 1.5e-06 28.3 0.0 0.11 12.7 0.0 3.2 2 1 0 2 2 2 2 Sigma-54 interaction domain IstB_IS21 PF01695.17 EPA05956.1 - 2.9e-06 27.1 0.0 0.13 12.0 0.0 2.8 3 0 0 3 3 2 2 IstB-like ATP binding protein TIP49 PF06068.13 EPA05956.1 - 5.9e-06 25.7 0.0 0.02 14.1 0.0 2.6 2 0 0 2 2 2 2 TIP49 P-loop domain Sigma54_activat PF00158.26 EPA05956.1 - 1.1e-05 25.2 0.0 1.1 9.0 0.0 3.9 3 1 0 3 3 3 2 Sigma-54 interaction domain AAA_7 PF12775.7 EPA05956.1 - 4.8e-05 23.0 0.2 0.15 11.6 0.0 3.2 3 1 0 3 3 3 2 P-loop containing dynein motor region ATPase PF06745.13 EPA05956.1 - 5.8e-05 22.5 0.6 0.49 9.7 0.0 3.6 2 1 1 3 3 3 2 KaiC Zeta_toxin PF06414.12 EPA05956.1 - 6.6e-05 22.3 0.0 0.15 11.3 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin NACHT PF05729.12 EPA05956.1 - 8.2e-05 22.6 0.3 2.1 8.3 0.0 3.4 3 0 0 3 3 3 2 NACHT domain AAA_11 PF13086.6 EPA05956.1 - 0.00024 21.0 0.0 0.12 12.1 0.0 2.7 2 1 0 2 2 2 1 AAA domain TsaE PF02367.17 EPA05956.1 - 0.00025 21.0 0.0 0.34 10.9 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2075 PF09848.9 EPA05956.1 - 0.00039 19.8 0.0 0.61 9.3 0.0 2.6 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 EPA05956.1 - 0.00039 20.2 0.0 0.17 11.6 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 EPA05956.1 - 0.00052 19.5 0.5 2.2 7.7 0.1 3.7 3 0 0 3 3 3 1 PhoH-like protein AAA_17 PF13207.6 EPA05956.1 - 0.0008 19.8 0.0 2.3 8.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain ATP-synt_ab PF00006.25 EPA05956.1 - 0.0013 18.5 0.1 1.7 8.2 0.0 3.2 2 1 1 3 3 3 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_3 PF07726.11 EPA05956.1 - 0.0015 18.3 0.0 3.7 7.4 0.0 3.2 4 1 0 4 4 2 0 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.10 EPA05956.1 - 0.0016 17.9 0.0 2.3 7.6 0.0 3.3 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit Parvo_NS1 PF01057.17 EPA05956.1 - 0.0022 17.1 0.1 1.8 7.6 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 NB-ARC PF00931.22 EPA05956.1 - 0.0034 16.6 0.3 2.7 7.1 0.0 3.2 3 0 0 3 3 3 1 NB-ARC domain DUF815 PF05673.13 EPA05956.1 - 0.0067 15.6 0.0 5.8 6.0 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF815) UFD1 PF03152.14 EPA05956.1 - 0.013 14.9 0.1 0.028 13.9 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 Vps4_C PF09336.10 EPA05956.1 - 0.022 14.7 0.2 7.1 6.7 0.0 2.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain SKI PF01202.22 EPA05956.1 - 0.032 14.3 0.1 8.5 6.5 0.0 2.7 3 0 0 3 3 2 0 Shikimate kinase KAP_NTPase PF07693.14 EPA05956.1 - 0.038 13.2 0.3 5.2 6.2 0.0 3.0 2 2 1 3 3 3 0 KAP family P-loop domain AAA_19 PF13245.6 EPA05956.1 - 0.043 14.2 1.1 13 6.2 0.0 2.8 3 0 0 3 3 2 0 AAA domain Cytidylate_kin PF02224.18 EPA05956.1 - 0.049 13.4 1.5 14 5.3 0.0 3.2 3 0 0 3 3 3 0 Cytidylate kinase IPT PF01745.16 EPA05956.1 - 0.059 12.8 0.1 0.62 9.4 0.1 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Hydin_ADK PF17213.3 EPA05956.1 - 0.061 13.6 2.1 13 6.0 0.0 3.7 5 0 0 5 5 3 0 Hydin Adenylate kinase-like domain Adeno_IVa2 PF02456.15 EPA05956.1 - 0.065 12.0 0.1 5.7 5.6 0.0 2.3 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_30 PF13604.6 EPA05956.1 - 0.068 12.9 0.2 24 4.5 0.0 3.0 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EPA05956.1 - 0.087 13.3 0.1 4.3 7.8 0.1 2.6 2 0 0 2 2 2 0 AAA domain Cytidylate_kin2 PF13189.6 EPA05956.1 - 0.11 12.7 0.0 9.6 6.3 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase-like family Aldedh PF00171.22 EPA05957.1 - 2.8e-138 461.3 0.0 3.5e-138 461.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF4806 PF16064.5 EPA05957.1 - 0.11 12.8 0.1 6.4 7.1 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4806) FAD_binding_3 PF01494.19 EPA05958.1 - 0.0056 16.0 0.0 0.0078 15.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Peptidase_C6 PF00851.18 EPA05958.1 - 0.05 12.5 0.2 0.068 12.1 0.2 1.1 1 0 0 1 1 1 0 Helper component proteinase Lycopene_cycl PF05834.12 EPA05958.1 - 0.18 10.8 0.0 2.3 7.2 0.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein SHS2_Rpb7-N PF03876.17 EPA05959.1 - 2.4e-15 56.6 0.0 5.7e-15 55.4 0.0 1.6 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EPA05959.1 - 4.5e-14 52.6 0.0 7.6e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 S1 RNA binding domain S1_2 PF13509.6 EPA05959.1 - 0.012 15.7 0.0 0.024 14.7 0.0 1.6 1 1 0 1 1 1 0 S1 domain BPL_C PF02237.17 EPA05959.1 - 0.03 14.2 0.0 0.069 13.1 0.0 1.6 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Arginase PF00491.21 EPA05960.1 - 1.3e-59 202.0 0.0 1.6e-59 201.7 0.0 1.0 1 0 0 1 1 1 1 Arginase family UbiA PF01040.18 EPA05961.1 - 2.3e-05 23.8 8.6 5.7e-05 22.5 8.5 1.6 1 1 0 1 1 1 1 UbiA prenyltransferase family PrgI PF12666.7 EPA05961.1 - 8.2 7.2 14.7 0.086 13.6 0.6 3.5 2 1 1 3 3 3 0 PrgI family protein Usp PF00582.26 EPA05962.1 - 8e-07 29.7 0.0 9e-07 29.5 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family MAD PF05557.13 EPA05962.1 - 0.0092 14.4 1.0 0.011 14.2 1.0 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein DUF711 PF05167.12 EPA05962.1 - 0.049 12.5 0.1 0.058 12.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised ACR (DUF711) Selenoprotein_S PF06936.11 EPA05962.1 - 0.068 13.0 1.2 0.088 12.6 1.2 1.2 1 0 0 1 1 1 0 Selenoprotein S (SelS) ARD PF03079.14 EPA05963.1 - 0.012 15.8 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family Cupin_2 PF07883.11 EPA05963.1 - 0.089 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Cupin domain DUF389 PF04087.14 EPA05964.1 - 2.5e-30 105.4 17.0 2.5e-30 105.4 17.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF389) TssN PF17555.2 EPA05964.1 - 0.2 11.0 11.3 0.34 10.2 2.3 2.2 2 0 0 2 2 2 0 Type VI secretion system, TssN PDT PF00800.18 EPA05965.1 - 9.1e-59 198.3 0.1 1.1e-58 198.0 0.1 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 EPA05965.1 - 0.0019 17.9 0.0 0.0034 17.1 0.0 1.4 1 0 0 1 1 1 1 ACT domain Ribosomal_L37e PF01907.19 EPA05966.1 - 0.013 15.6 0.3 0.016 15.3 0.3 1.1 1 0 0 1 1 1 0 Ribosomal protein L37e Prok-RING_1 PF14446.6 EPA05966.1 - 0.014 15.3 0.5 0.017 15.1 0.5 1.1 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DNA_RNApol_7kD PF03604.13 EPA05966.1 - 0.19 11.4 8.0 2.9 7.6 8.0 2.1 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit zf-ACC PF17848.1 EPA05966.1 - 0.31 11.1 4.7 4.6 7.4 0.5 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain ResB PF05140.14 EPA05968.1 - 0.016 14.0 0.5 0.12 11.1 0.5 1.9 1 1 0 1 1 1 0 ResB-like family ChapFlgA_N PF17656.1 EPA05968.1 - 0.086 13.0 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 FlgA N-terminal domain DNA_primase_lrg PF04104.14 EPA05969.1 - 8.3e-27 94.2 0.0 2e-26 93.0 0.0 1.7 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Med5 PF08689.10 EPA05969.1 - 0.0014 16.6 0.1 0.0017 16.3 0.1 1.1 1 0 0 1 1 1 1 Mediator complex subunit Med5 DNA_primase_S PF01896.19 EPA05970.1 - 4.4e-11 43.1 1.4 5e-09 36.4 1.4 2.4 1 1 0 1 1 1 1 DNA primase small subunit PolC_DP2 PF03833.13 EPA05970.1 - 0.018 13.0 4.2 0.022 12.6 4.2 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 HypA PF01155.19 EPA05970.1 - 0.21 11.6 9.4 2.3 8.3 9.3 2.4 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DNA_primase_S PF01896.19 EPA05971.1 - 4e-11 43.3 0.9 6.3e-09 36.1 0.9 2.4 1 1 0 1 1 1 1 DNA primase small subunit PolC_DP2 PF03833.13 EPA05971.1 - 0.017 13.0 5.4 0.022 12.7 5.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DUF3624 PF12292.8 EPA05971.1 - 0.26 11.7 2.3 0.53 10.7 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3624) HypA PF01155.19 EPA05971.1 - 8.3 6.5 12.1 30 4.7 12.1 2.1 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DNA_primase_lrg PF04104.14 EPA05973.1 - 2.1e-24 86.3 0.1 3.3e-24 85.7 0.1 1.3 1 1 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit HATPase_c PF02518.26 EPA05974.1 - 5.3e-17 62.3 0.0 1.5e-16 60.8 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EPA05974.1 - 8e-09 35.4 0.3 8e-09 35.4 0.3 2.3 2 1 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EPA05974.1 - 8.2e-07 28.9 2.4 1.1e-06 28.5 0.0 2.4 2 1 0 2 2 2 1 GHKL domain HATPase_c_2 PF13581.6 EPA05974.1 - 0.0023 17.9 0.0 0.0057 16.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain GlcNAc-1_reg PF18440.1 EPA05974.1 - 1 9.7 7.6 0.09 13.0 1.0 2.6 3 0 0 3 3 3 0 Putative GlcNAc-1 phosphotransferase regulatory domain STI1 PF17830.1 EPA05975.1 - 1.5e-05 24.8 37.4 0.0044 16.9 8.8 3.8 2 2 1 3 3 3 3 STI1 domain GerD PF17898.1 EPA05975.1 - 5e-05 23.2 24.0 0.00026 20.9 11.3 2.1 1 1 1 2 2 2 2 Spore germination GerD central core domain PutA_N PF18083.1 EPA05975.1 - 0.0093 16.0 9.4 0.3 11.1 0.4 2.9 1 1 2 3 3 3 2 Proline utilization A N-terminal domain Bep_C_terminal PF17841.1 EPA05975.1 - 0.014 15.6 1.8 0.21 11.8 0.1 2.2 1 1 1 2 2 2 0 BID domain of Bartonella effector protein (Bep) Sulfotransfer_3 PF13469.6 EPA05975.1 - 0.015 15.7 1.3 0.021 15.2 0.8 1.4 1 1 0 1 1 1 0 Sulfotransferase family XPC-binding PF09280.11 EPA05975.1 - 0.043 13.6 11.3 1 9.2 0.2 3.3 1 1 0 2 2 2 0 XPC-binding domain DUF4934 PF16288.5 EPA05975.1 - 0.12 12.3 0.0 2.2 8.2 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4934) Cupin_4 PF08007.12 EPA05975.1 - 0.15 11.5 3.6 0.18 11.2 3.0 1.4 1 1 0 1 1 1 0 Cupin superfamily protein EF-hand_3 PF09069.11 EPA05975.1 - 0.27 11.7 5.0 38 4.8 4.8 2.8 1 1 0 1 1 1 0 EF-hand HmuY PF14064.6 EPA05975.1 - 4.3 7.5 8.5 5.9 7.1 8.5 1.5 1 1 0 1 1 1 0 HmuY protein NitrOD1 PF18549.1 EPA05976.1 - 2.2e-38 130.1 2.9 2.3e-38 129.9 2.9 1.0 1 0 0 1 1 1 1 Nitrosopumilus output domain 1 Topoisom_I_N PF02919.15 EPA05977.1 - 1.6e-42 145.5 5.2 1.7e-42 145.3 5.2 1.0 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, DNA binding fragment DUF1947 PF09183.10 EPA05977.1 - 0.16 12.3 5.2 6.9 7.1 0.3 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF1947) AzlD PF05437.12 EPA05978.1 - 0.0061 16.7 0.3 4.3 7.6 0.0 2.1 2 0 0 2 2 2 2 Branched-chain amino acid transport protein (AzlD) DsbD PF02683.15 EPA05978.1 - 0.0098 15.8 2.2 0.0098 15.8 2.2 1.4 2 0 0 2 2 2 1 Cytochrome C biogenesis protein transmembrane region DUF3188 PF11384.8 EPA05978.1 - 0.021 14.5 1.3 5.9 6.7 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3188) DUF2304 PF10066.9 EPA05978.1 - 0.041 14.1 0.6 0.11 12.7 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) DUF2892 PF11127.8 EPA05978.1 - 0.047 13.7 2.1 0.086 12.9 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2892) YpmT PF17431.2 EPA05979.1 - 0.029 14.4 0.0 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized YmpT-like Insulin_TMD PF17870.1 EPA05979.1 - 1.5 8.9 5.7 8.5 6.5 2.2 2.3 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Myb_DNA-bind_4 PF13837.6 EPA05980.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF1059 PF06348.11 EPA05981.1 - 1.6e-06 28.2 0.0 1.7e-06 28.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) MAP PF03642.13 EPA05981.1 - 0.053 13.8 0.1 0.056 13.8 0.1 1.1 1 0 0 1 1 1 0 MAP domain Thioredoxin_3 PF13192.6 EPA05982.1 - 2.8e-16 59.3 0.2 3.2e-16 59.1 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin domain Glutaredoxin PF00462.24 EPA05982.1 - 1.7e-10 41.0 0.0 2.3e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 EPA05982.1 - 0.00021 21.6 0.0 0.00022 21.6 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) GST_N_3 PF13417.6 EPA05982.1 - 0.00035 20.9 0.0 0.00045 20.6 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain KaiB PF07689.12 EPA05982.1 - 0.0059 16.3 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 KaiB domain DUF1223 PF06764.11 EPA05982.1 - 0.02 14.9 0.1 0.98 9.4 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1223) GST_N PF02798.20 EPA05982.1 - 0.074 13.4 0.0 0.091 13.1 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain SlyX PF04102.12 EPA05983.1 - 0.002 18.7 0.2 0.0071 16.9 0.2 2.0 1 0 0 1 1 1 1 SlyX CLZ PF16526.5 EPA05983.1 - 0.023 15.0 1.6 0.023 15.0 1.6 2.6 3 1 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Arm-DNA-bind_5 PF17293.2 EPA05983.1 - 0.11 12.9 0.2 0.11 12.9 0.2 2.2 2 1 0 2 2 2 0 Arm DNA-binding domain RIC3 PF15361.6 EPA05983.1 - 0.15 12.5 0.3 0.15 12.5 0.3 2.3 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 Trypan_PARP PF05887.11 EPA05983.1 - 0.22 11.5 17.9 0.42 10.6 17.9 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Methyltransf_14 PF08484.11 EPA05983.1 - 0.22 11.3 0.8 0.53 10.1 0.8 1.6 1 0 0 1 1 1 0 C-methyltransferase C-terminal domain Laminin_II PF06009.12 EPA05983.1 - 6.9 6.7 11.5 0.039 14.0 2.4 1.9 2 1 0 2 2 2 0 Laminin Domain II BUD22 PF09073.10 EPA05983.1 - 9.2 5.5 29.3 12 5.0 29.3 1.1 1 0 0 1 1 1 0 BUD22 YHS PF04945.13 EPA05986.1 - 1.1e-17 63.9 0.6 1.1e-17 63.8 0.6 1.0 1 0 0 1 1 1 1 YHS domain zf-FCS PF06467.14 EPA05986.1 - 7.7e-05 22.6 0.4 9.5e-05 22.3 0.4 1.2 1 0 0 1 1 1 1 MYM-type Zinc finger with FCS sequence motif zf-FLZ PF04570.14 EPA05986.1 - 0.016 14.6 0.1 0.02 14.4 0.1 1.2 1 0 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 FAP206 PF12018.8 EPA05986.1 - 0.046 13.2 0.1 0.05 13.1 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function DUF2116 PF09889.9 EPA05986.1 - 0.1 12.6 1.3 0.77 9.8 1.3 1.9 1 1 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DEAD PF00270.29 EPA05987.1 - 1.7e-33 115.8 0.1 4.9e-33 114.3 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EPA05987.1 - 1.3e-17 64.1 2.3 2.3e-13 50.5 0.5 3.5 4 0 0 4 4 4 2 Helicase conserved C-terminal domain DUF1998 PF09369.10 EPA05987.1 - 1.7e-09 38.3 0.1 5.3e-09 36.7 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) SNF2_N PF00176.23 EPA05987.1 - 0.019 13.7 0.0 0.03 13.0 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain RNA_POL_M_15KD PF02150.16 EPA05987.1 - 0.12 12.2 2.4 0.31 10.9 2.4 1.7 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit zinc_ribbon_4 PF13717.6 EPA05987.1 - 1.3 9.0 13.1 0.29 11.1 4.7 2.9 2 1 0 2 2 2 0 zinc-ribbon domain Response_reg PF00072.24 EPA05988.1 - 1.5e-25 89.6 0.7 3.8e-25 88.2 0.7 1.6 2 0 0 2 2 2 1 Response regulator receiver domain DUF5475 PF17569.2 EPA05988.1 - 0.02 15.2 0.0 0.053 13.8 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5475) adh_short PF00106.25 EPA05989.1 - 2.5e-50 170.7 0.1 3.5e-50 170.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EPA05989.1 - 6.2e-37 127.4 0.0 8.3e-37 127.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EPA05989.1 - 5.3e-09 36.2 0.0 7.7e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EPA05989.1 - 4.9e-08 32.7 0.1 5.4e-07 29.3 0.1 2.1 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) NmrA PF05368.13 EPA05989.1 - 0.0044 16.6 0.1 0.016 14.7 0.1 1.8 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EPA05989.1 - 0.043 13.7 0.1 0.088 12.7 0.1 1.7 1 1 0 1 1 1 0 NAD(P)H-binding Response_reg PF00072.24 EPA05990.1 - 1.3e-24 86.5 0.1 1.6e-24 86.2 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain TP_methylase PF00590.20 EPA05993.1 - 1.6e-56 191.6 0.0 1.8e-56 191.4 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases TP_methylase PF00590.20 EPA05998.1 - 9.8e-47 159.6 0.1 1.2e-46 159.4 0.1 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Radical_SAM PF04055.21 EPA05998.1 - 0.024 15.0 0.0 0.042 14.2 0.0 1.5 1 1 0 1 1 1 0 Radical SAM superfamily Aldolase PF01081.19 EPA05998.1 - 0.033 13.6 0.1 0.073 12.5 0.1 1.5 1 0 0 1 1 1 0 KDPG and KHG aldolase V-ATPase_H_N PF03224.14 EPA05998.1 - 0.042 13.1 0.5 0.12 11.6 0.0 1.9 3 0 0 3 3 3 0 V-ATPase subunit H UvrA_inter PF17760.1 EPA05998.1 - 0.059 13.5 0.0 1 9.5 0.0 2.4 2 0 0 2 2 2 0 UvrA interaction domain ESAG1 PF03238.13 EPA05998.1 - 0.1 12.0 0.1 0.41 10.1 0.1 1.7 2 0 0 2 2 2 0 ESAG protein PPR_1 PF12854.7 EPA05998.1 - 0.19 11.4 0.1 0.35 10.6 0.1 1.5 1 0 0 1 1 1 0 PPR repeat CitMHS PF03600.16 EPA05999.1 - 2e-38 132.3 41.7 3.2e-38 131.6 36.5 2.2 1 1 1 2 2 2 2 Citrate transporter ArsB PF02040.15 EPA05999.1 - 9.4e-07 28.5 32.9 1.7e-06 27.6 32.9 1.4 1 1 0 1 1 1 1 Arsenical pump membrane protein DUF3767 PF12597.8 EPA05999.1 - 7.8 6.4 5.2 17 5.3 0.9 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3767) HGTP_anticodon PF03129.20 EPA06000.1 - 2.7e-10 40.3 0.3 3.9e-10 39.7 0.3 1.2 1 0 0 1 1 1 1 Anticodon binding domain RcpB PF16971.5 EPA06000.1 - 0.032 14.1 1.0 0.047 13.6 0.5 1.4 1 1 0 1 1 1 0 Rough colony protein B, tight adherence - tad - subunit tRNA-synt_His PF13393.6 EPA06000.1 - 0.1 11.9 0.6 0.2 10.9 0.6 1.5 1 0 0 1 1 1 0 Histidyl-tRNA synthetase Fer4 PF00037.27 EPA06001.1 - 8.7e-10 38.0 11.9 6.4e-06 25.8 1.3 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EPA06001.1 - 1.2e-09 38.6 2.7 7.9e-05 23.2 0.8 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 EPA06001.1 - 5.3e-08 33.7 3.9 0.00034 21.5 0.9 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 EPA06001.1 - 6.9e-08 32.5 15.3 4.2e-07 30.0 5.1 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EPA06001.1 - 2.9e-07 30.5 6.4 1.6e-06 28.2 6.8 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 EPA06001.1 - 4.5e-07 29.9 4.6 0.0009 19.3 0.7 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 EPA06001.1 - 7.8e-07 29.5 0.7 0.017 15.6 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EPA06001.1 - 6e-06 26.1 12.5 0.01 15.9 3.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 EPA06001.1 - 0.00024 21.7 4.0 0.027 15.2 0.3 2.6 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_4 PF12800.7 EPA06001.1 - 0.00045 20.5 6.0 0.036 14.6 1.2 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_18 PF13746.6 EPA06001.1 - 0.00049 20.3 5.9 0.00056 20.1 4.0 1.9 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 EPA06001.1 - 0.00078 19.4 11.6 0.055 13.6 3.6 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EPA06001.1 - 0.0014 19.2 5.7 0.11 13.0 7.9 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 EPA06001.1 - 0.01 16.3 13.8 0.18 12.4 2.6 2.6 2 1 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_22 PF17179.4 EPA06001.1 - 0.012 16.5 0.7 6.1 7.8 0.1 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 EPA06001.1 - 0.078 14.0 14.9 1.8 9.7 6.4 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain eIF-6 PF01912.18 EPA06002.1 - 1e-62 211.0 1.2 1.2e-62 210.8 1.2 1.1 1 0 0 1 1 1 1 eIF-6 family RIO1 PF01163.22 EPA06003.1 - 3.3e-52 176.8 0.0 4.2e-52 176.5 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 EPA06003.1 - 0.0092 14.8 0.0 0.013 14.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EPA06003.1 - 0.01 15.8 0.0 3.9 7.3 0.0 2.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family BBS2_Mid PF14783.6 EPA06003.1 - 0.026 14.6 0.0 0.052 13.6 0.0 1.4 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region Kdo PF06293.14 EPA06003.1 - 0.094 12.1 0.0 2.7 7.3 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family TP6A_N PF04406.14 EPA06004.1 - 4.6e-15 55.3 0.1 7.6e-15 54.6 0.1 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase Toprim PF01751.22 EPA06004.1 - 0.048 13.9 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Toprim domain Cupredoxin_1 PF13473.6 EPA06006.1 - 1.7e-10 41.0 0.0 2e-10 40.7 0.0 1.3 1 1 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 EPA06006.1 - 5.8e-09 36.3 0.0 1.1e-08 35.4 0.0 1.5 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Prenyltransf PF01255.19 EPA06007.1 - 9.9e-63 211.7 0.0 1.1e-62 211.5 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase zinc_ribbon_2 PF13240.6 EPA06008.1 - 0.0021 17.7 1.5 0.13 12.0 0.2 2.3 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 EPA06008.1 - 0.0037 17.2 0.8 0.0053 16.8 0.8 1.2 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 EPA06008.1 - 0.019 15.0 0.7 0.021 14.8 0.7 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.5 EPA06008.1 - 0.027 15.2 0.8 0.032 15.0 0.8 1.1 1 0 0 1 1 1 0 zinc-ribbon family zf-ribbon_3 PF13248.6 EPA06008.1 - 0.056 12.9 2.6 0.26 10.7 0.3 2.1 2 0 0 2 2 2 0 zinc-ribbon domain Zn_ribbon_SprT PF17283.2 EPA06008.1 - 0.074 13.0 2.2 6.3 6.8 0.1 2.1 2 0 0 2 2 2 0 SprT-like zinc ribbon domain GFA PF04828.14 EPA06008.1 - 0.1 13.0 2.3 0.3 11.5 2.3 1.7 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme Zn-ribbon_8 PF09723.10 EPA06008.1 - 0.16 12.1 3.3 0.47 10.6 3.3 1.7 1 1 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_4 PF13717.6 EPA06008.1 - 0.16 11.9 6.9 0.77 9.7 6.9 1.9 1 1 0 1 1 1 0 zinc-ribbon domain Auto_anti-p27 PF06677.12 EPA06008.1 - 0.18 12.0 4.2 1.1 9.5 0.1 2.2 2 1 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) CBFD_NFYB_HMF PF00808.23 EPA06009.1 - 1e-13 51.3 0.5 1.2e-13 51.1 0.5 1.0 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EPA06009.1 - 4.9e-05 23.6 0.0 5.7e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 EPA06009.1 - 6.3e-05 23.3 0.2 7.4e-05 23.1 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EPA06009.1 - 0.00013 22.0 0.1 0.00015 21.8 0.1 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 EPA06009.1 - 0.00074 19.5 0.0 0.00087 19.3 0.0 1.1 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 EPA06009.1 - 0.00092 19.3 0.0 0.0011 19.0 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit TFIID_20kDa PF03847.13 EPA06009.1 - 0.0014 19.1 0.0 0.0017 18.8 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TAF PF02969.17 EPA06009.1 - 0.0067 16.6 0.5 0.0078 16.4 0.5 1.1 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) DUF1931 PF09123.11 EPA06009.1 - 0.0069 16.5 0.2 0.0077 16.3 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1931) DUF2120 PF09893.9 EPA06009.1 - 0.017 15.3 0.2 0.021 14.9 0.2 1.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) TFIID-18kDa PF02269.16 EPA06009.1 - 0.029 14.4 0.0 0.031 14.3 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit TFIIB PF00382.19 EPA06009.1 - 0.065 13.3 0.1 0.094 12.8 0.1 1.3 1 0 0 1 1 1 0 Transcription factor TFIIB repeat MR_MLE_N PF02746.16 EPA06009.1 - 0.089 13.0 0.1 0.099 12.9 0.1 1.1 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain TrmB PF01978.19 EPA06010.1 - 0.00022 21.1 0.0 0.00027 20.8 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Sigma70_r4 PF04545.16 EPA06010.1 - 0.13 11.8 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 DUF424 PF04242.13 EPA06011.1 - 1.5e-22 79.7 0.5 1.7e-22 79.5 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF424) Adenylsucc_synt PF00709.21 EPA06012.1 - 2.8e-83 280.2 1.1 3.9e-40 138.1 0.0 3.0 1 1 2 3 3 3 3 Adenylosuccinate synthetase zinc_ribbon_6 PF14599.6 EPA06013.1 - 0.017 15.1 1.4 0.023 14.7 1.4 1.2 1 0 0 1 1 1 0 Zinc-ribbon zf-TFIIB PF13453.6 EPA06013.1 - 0.023 14.0 0.8 0.15 11.4 1.8 1.8 2 0 0 2 2 2 0 Transcription factor zinc-finger Ribosomal_S27e PF01667.17 EPA06013.1 - 0.043 13.5 4.0 0.079 12.7 4.0 1.4 1 1 0 1 1 1 0 Ribosomal protein S27 HypA PF01155.19 EPA06013.1 - 0.081 13.0 0.4 0.092 12.8 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA YacG PF03884.14 EPA06013.1 - 0.18 11.6 2.7 1.3 8.8 2.8 2.0 1 1 1 2 2 2 0 DNA gyrase inhibitor YacG zinc_ribbon_4 PF13717.6 EPA06013.1 - 0.18 11.7 6.8 2.4 8.2 6.8 2.1 1 1 0 1 1 1 0 zinc-ribbon domain zf-ACC PF17848.1 EPA06013.1 - 5.3 7.2 8.3 8.6 6.5 2.7 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain eIF-5_eIF-2B PF01873.17 EPA06014.1 - 1.4e-29 102.3 0.0 1.7e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Elf1 PF05129.13 EPA06014.1 - 0.068 13.2 0.2 0.13 12.3 0.2 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Lar_restr_allev PF14354.6 EPA06014.1 - 0.096 13.1 0.3 0.15 12.5 0.3 1.3 1 0 0 1 1 1 0 Restriction alleviation protein Lar PDCD2_C PF04194.13 EPA06014.1 - 0.11 12.6 0.1 0.13 12.3 0.1 1.3 1 1 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain GATA PF00320.27 EPA06014.1 - 0.13 11.9 0.7 0.3 10.7 0.7 1.6 1 0 0 1 1 1 0 GATA zinc finger DUF373 PF04123.13 EPA06015.1 - 3.9e-89 299.4 15.4 4.7e-89 299.1 15.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF373) SPC12 PF06645.13 EPA06015.1 - 7 6.8 7.2 0.5 10.5 0.5 2.5 2 1 2 4 4 4 0 Microsomal signal peptidase 12 kDa subunit (SPC12) KH_1 PF00013.29 EPA06016.1 - 9.1e-10 38.2 10.1 8.8e-05 22.3 1.2 2.7 2 1 1 3 3 3 2 KH domain GP57 PF17594.2 EPA06016.1 - 0.0082 15.9 0.1 0.026 14.2 0.0 1.8 2 0 0 2 2 2 1 Phage Tail fiber assembly helper gene product 57 KH_2 PF07650.17 EPA06016.1 - 0.03 14.1 5.6 2.8 7.9 0.2 2.9 2 1 0 2 2 2 0 KH domain DUF4335 PF14233.6 EPA06016.1 - 0.16 11.8 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4335) THUMP PF02926.17 EPA06017.1 - 2.6e-13 50.3 1.7 3.2e-13 50.0 1.7 1.1 1 0 0 1 1 1 1 THUMP domain MAT1 PF06391.13 EPA06018.1 - 0.98 9.2 7.3 0.86 9.4 2.6 2.1 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 OMPdecase PF00215.24 EPA06019.1 - 3.3e-26 92.3 0.0 3.8e-26 92.1 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Ribosomal_S17e PF00833.18 EPA06020.1 - 1.5e-18 66.8 4.5 2.2e-18 66.3 4.5 1.3 1 1 0 1 1 1 1 Ribosomal S17 DUF4201 PF13870.6 EPA06020.1 - 0.016 15.0 3.8 0.019 14.7 3.5 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) NUDIX_5 PF16705.5 EPA06020.1 - 0.018 14.8 1.6 0.15 11.8 0.2 2.0 1 1 1 2 2 2 0 NUDIX, or N-terminal NPxY motif-rich, region of KRIT Annexin PF00191.20 EPA06022.1 - 0.0015 18.6 0.1 0.0028 17.7 0.1 1.4 1 0 0 1 1 1 1 Annexin Catalase-rel PF06628.12 EPA06022.1 - 0.0062 16.7 0.1 30 4.9 0.0 3.2 3 0 0 3 3 3 2 Catalase-related immune-responsive Topo-VIb_trans PF09239.11 EPA06023.1 - 9.1e-55 184.8 0.0 1.4e-54 184.2 0.0 1.3 1 0 0 1 1 1 1 Topoisomerase VI B subunit, transducer HATPase_c PF02518.26 EPA06023.1 - 2.9e-06 27.7 0.0 6e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EPA06023.1 - 0.00033 20.5 0.0 0.00071 19.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HTH_45 PF14947.6 EPA06024.1 - 1.9e-11 43.7 0.2 2.5e-11 43.4 0.2 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix MarR_2 PF12802.7 EPA06024.1 - 2.9e-07 30.3 0.0 3.9e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_IclR PF09339.10 EPA06024.1 - 5.7e-05 22.8 0.0 7.4e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 IclR helix-turn-helix domain RP-C PF03428.13 EPA06024.1 - 0.00028 20.6 0.1 0.00033 20.4 0.1 1.1 1 0 0 1 1 1 1 Replication protein C N-terminal domain DUF4364 PF14277.6 EPA06024.1 - 0.00033 20.4 0.0 0.00044 20.0 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4364) MarR PF01047.22 EPA06024.1 - 0.00042 20.2 0.0 0.0006 19.7 0.0 1.2 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 EPA06024.1 - 0.00048 20.0 0.0 0.00066 19.5 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 EPA06024.1 - 0.0007 19.1 0.4 0.0014 18.1 0.1 1.6 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding RQC PF09382.10 EPA06024.1 - 0.0033 17.2 0.0 0.0045 16.8 0.0 1.2 1 0 0 1 1 1 1 RQC domain HTH_27 PF13463.6 EPA06024.1 - 0.0036 17.7 0.0 0.0044 17.5 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain Dimerisation2 PF16864.5 EPA06024.1 - 0.004 17.1 0.0 0.005 16.8 0.0 1.2 1 0 0 1 1 1 1 Dimerisation domain Linker_histone PF00538.19 EPA06024.1 - 0.006 16.9 0.1 0.014 15.7 0.1 1.7 1 1 0 1 1 1 1 linker histone H1 and H5 family FtsK_gamma PF09397.10 EPA06024.1 - 0.0089 15.8 0.1 0.011 15.5 0.1 1.2 1 0 0 1 1 1 1 Ftsk gamma domain RPA_C PF08784.11 EPA06024.1 - 0.0094 16.6 0.0 0.013 16.1 0.0 1.2 1 0 0 1 1 1 1 Replication protein A C terminal Mrr_N PF14338.6 EPA06024.1 - 0.013 15.6 0.0 0.018 15.1 0.0 1.4 1 1 0 1 1 1 0 Mrr N-terminal domain Rrf2 PF02082.20 EPA06024.1 - 0.015 15.6 0.1 0.019 15.3 0.1 1.2 1 0 0 1 1 1 0 Transcriptional regulator HTH_5 PF01022.20 EPA06024.1 - 0.019 14.8 0.1 0.034 14.0 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family DUF1495 PF07381.11 EPA06024.1 - 0.021 14.6 0.0 0.028 14.2 0.0 1.5 1 1 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) HTH_36 PF13730.6 EPA06024.1 - 0.025 14.6 0.2 0.04 13.9 0.1 1.5 2 0 0 2 2 1 0 Helix-turn-helix domain Ribosomal_S25 PF03297.15 EPA06024.1 - 0.025 14.7 0.1 0.031 14.5 0.1 1.2 1 0 0 1 1 1 0 S25 ribosomal protein RNA_pol_Rpc34 PF05158.12 EPA06024.1 - 0.028 13.8 0.1 0.032 13.6 0.1 1.0 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit DUF4194 PF13835.6 EPA06024.1 - 0.03 14.1 0.1 0.036 13.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4194) PadR PF03551.14 EPA06024.1 - 0.036 14.0 0.0 0.046 13.7 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family DUF2250 PF10007.9 EPA06024.1 - 0.051 13.7 0.1 0.093 12.9 0.1 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) Cdc6_C PF09079.11 EPA06024.1 - 0.055 13.5 0.1 0.083 12.9 0.1 1.3 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain HTH_20 PF12840.7 EPA06024.1 - 0.064 13.3 0.0 0.091 12.8 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain B-block_TFIIIC PF04182.12 EPA06024.1 - 0.084 13.0 0.3 0.12 12.6 0.3 1.1 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC HTH_46 PF15977.5 EPA06024.1 - 0.11 12.6 0.9 0.16 12.0 0.6 1.5 1 1 0 1 1 1 0 Winged helix-turn-helix DNA binding Replic_Relax PF13814.6 EPA06024.1 - 0.11 12.5 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 Replication-relaxation NUDIX PF00293.28 EPA06025.1 - 9.5e-21 74.2 0.4 1.1e-20 74.0 0.4 1.0 1 0 0 1 1 1 1 NUDIX domain PhosphMutase PF10143.9 EPA06025.1 - 0.04 13.8 0.2 0.055 13.4 0.2 1.1 1 0 0 1 1 1 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase TatD_DNase PF01026.21 EPA06027.1 - 1.5e-45 155.6 0.0 1.7e-45 155.4 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase BP28CT PF08146.12 EPA06027.1 - 0.05 13.4 0.1 0.079 12.8 0.1 1.3 1 0 0 1 1 1 0 BP28CT (NUC211) domain FAD_binding_7 PF03441.14 EPA06027.1 - 0.18 11.3 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain of DNA photolyase Iron_traffic PF04362.14 EPA06028.1 - 1.9e-07 30.7 0.0 2.2e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial Fe(2+) trafficking XPA_N PF01286.18 EPA06028.1 - 0.067 13.2 2.1 8.2 6.6 0.1 2.2 2 0 0 2 2 2 0 XPA protein N-terminal zf_C2H2_13 PF18508.1 EPA06028.1 - 0.91 9.2 4.1 3 7.5 0.2 2.4 1 1 1 2 2 2 0 Zinc finger domain DUF2207 PF09972.9 EPA06029.1 - 0.029 13.1 1.1 0.038 12.8 1.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) LptF_LptG PF03739.14 EPA06029.1 - 0.052 12.4 0.8 0.066 12.0 0.8 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG DUF4870 PF09685.10 EPA06029.1 - 0.059 13.5 1.7 0.085 13.0 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4870) Shisa PF13908.6 EPA06029.1 - 0.13 12.5 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator VEGFR-2_TMD PF17988.1 EPA06029.1 - 0.17 11.4 2.3 0.35 10.4 2.3 1.5 1 0 0 1 1 1 0 VEGFR-2 Transmembrane domain RseC_MucC PF04246.12 EPA06029.1 - 0.19 11.6 0.3 0.28 11.1 0.3 1.2 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC ABC2_membrane_3 PF12698.7 EPA06029.1 - 3.7 6.6 8.9 11 5.0 8.6 1.7 1 1 1 2 2 2 0 ABC-2 family transporter protein BaxI_1 PF12811.7 EPA06031.1 - 0.0021 17.7 2.2 0.0021 17.6 2.2 1.0 1 0 0 1 1 1 1 Bax inhibitor 1 like ThiS PF02597.20 EPA06032.1 - 4e-07 30.6 0.1 1.1e-06 29.1 0.0 1.8 2 0 0 2 2 2 1 ThiS family CGI-121 PF08617.10 EPA06032.1 - 0.0004 20.5 3.9 0.00076 19.6 3.5 1.7 2 0 0 2 2 2 1 Kinase binding protein CGI-121 Urm1 PF09138.11 EPA06032.1 - 0.0058 17.0 2.1 0.011 16.1 0.4 2.5 2 2 1 3 3 3 1 Urm1 (Ubiquitin related modifier) Staphostatin_A PF09022.10 EPA06032.1 - 1.5 8.8 8.6 1.6 8.7 1.8 3.0 1 1 1 3 3 3 0 Staphostatin A Cdc6_C PF09079.11 EPA06033.1 - 0.00022 21.1 0.2 0.00025 20.9 0.2 1.1 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain DUF512 PF04459.12 EPA06033.1 - 0.0047 16.2 0.1 0.0052 16.1 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF512) DNA_pol_E_B PF04042.16 EPA06034.1 - 1.3e-05 24.6 0.0 2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Metallophos_2 PF12850.7 EPA06034.1 - 0.00095 19.4 0.0 0.0011 19.2 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DNA_pol_E_B PF04042.16 EPA06035.1 - 1.3e-05 24.6 0.0 2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Metallophos_2 PF12850.7 EPA06035.1 - 0.00095 19.4 0.0 0.0011 19.2 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Cdc6_C PF09079.11 EPA06036.1 - 4.8e-08 32.9 0.5 5.5e-08 32.7 0.5 1.1 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain DUF512 PF04459.12 EPA06036.1 - 0.0014 18.0 0.1 0.0016 17.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF512) CPBP PF02517.16 EPA06037.1 - 0.0059 17.0 3.0 0.0059 17.0 3.0 3.0 2 1 0 3 3 3 1 CPBP intramembrane metalloprotease NADH_oxidored PF08040.11 EPA06037.1 - 0.27 11.0 0.2 0.27 11.0 0.2 2.0 2 0 0 2 2 2 0 MNLL subunit Thioredoxin_4 PF13462.6 EPA06038.1 - 2e-40 138.7 0.1 4e-40 137.7 0.0 1.5 2 0 0 2 2 2 1 Thioredoxin DSBA PF01323.20 EPA06038.1 - 6e-20 71.8 0.4 6.1e-18 65.3 0.4 2.2 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 EPA06038.1 - 2e-11 44.3 0.1 5.8e-11 42.8 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_5 PF13743.6 EPA06038.1 - 0.038 13.7 0.0 0.068 12.8 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin TackOD1 PF18551.1 EPA06039.1 - 6e-27 94.5 15.0 9e-27 94.0 15.0 1.2 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 Response_reg PF00072.24 EPA06039.1 - 5.4e-11 42.6 0.0 8.9e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain zinc-ribbons_6 PF07191.12 EPA06039.1 - 0.0074 16.3 15.8 0.25 11.3 2.5 3.0 1 1 1 3 3 3 3 zinc-ribbons Sgf11 PF08209.11 EPA06039.1 - 0.014 14.9 7.6 0.34 10.5 0.2 3.6 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) zf-FPG_IleRS PF06827.14 EPA06039.1 - 0.041 13.7 3.8 0.31 10.9 0.1 3.0 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS Zn_Tnp_IS1595 PF12760.7 EPA06039.1 - 0.1 12.6 0.6 0.1 12.6 0.6 3.3 3 1 0 3 3 3 0 Transposase zinc-ribbon domain zf_UBZ PF18439.1 EPA06039.1 - 0.15 11.6 14.5 0.73 9.5 0.1 4.4 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger DZR PF12773.7 EPA06039.1 - 0.36 10.9 17.2 4.7 7.3 2.0 3.1 1 1 2 3 3 3 0 Double zinc ribbon Thioredoxin_4 PF13462.6 EPA06039.1 - 0.62 10.2 6.6 29 4.8 0.2 3.3 2 1 1 3 3 3 0 Thioredoxin zf-C3HC4_3 PF13920.6 EPA06039.1 - 1.1 9.1 14.0 7.6 6.5 0.2 3.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Rubredoxin_2 PF18073.1 EPA06039.1 - 1.4 8.7 12.3 0.63 9.8 0.4 3.7 3 1 0 3 3 3 0 Rubredoxin metal binding domain HNH_5 PF14279.6 EPA06039.1 - 1.4 8.8 11.3 0.97 9.3 1.6 3.5 2 1 1 3 3 3 0 HNH endonuclease Spt4 PF06093.13 EPA06039.1 - 1.4 9.1 14.4 0.26 11.4 1.0 3.3 3 0 0 3 3 3 0 Spt4/RpoE2 zinc finger HypA PF01155.19 EPA06039.1 - 1.5 8.9 18.9 2.8 8.0 1.2 3.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_1 PF00130.22 EPA06039.1 - 2.5 8.1 13.5 0.84 9.6 1.4 3.3 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Evr1_Alr PF04777.13 EPA06039.1 - 2.6 8.6 5.9 2.3 8.7 0.5 2.6 2 0 0 2 2 2 0 Erv1 / Alr family Radical_SAM PF04055.21 EPA06043.1 - 5.7e-05 23.6 0.1 0.00019 21.8 0.1 2.1 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EPA06043.1 - 0.00093 19.5 0.1 0.0022 18.3 0.1 1.7 1 1 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EPA06043.1 - 0.0011 19.1 0.0 0.0045 17.1 0.0 2.0 1 1 1 2 2 2 1 4Fe-4S single cluster domain Flg_hook PF02120.16 EPA06043.1 - 0.29 11.1 1.1 0.44 10.5 0.1 1.8 2 0 0 2 2 2 0 Flagellar hook-length control protein FliK Peptidase_S8 PF00082.22 EPA06045.1 - 1.4e-48 165.7 15.1 2.2e-48 165.1 15.1 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EPA06045.1 - 6.8e-08 33.1 0.0 1.6e-07 31.9 0.0 1.6 1 1 0 1 1 1 1 Peptidase inhibitor I9 TPP_enzyme_N PF02776.18 EPA06046.1 - 3.6e-55 186.2 0.0 1.3e-53 181.1 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EPA06046.1 - 3.8e-39 133.9 0.0 1.1e-38 132.4 0.0 1.8 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EPA06046.1 - 1.4e-31 109.0 0.2 4.1e-31 107.5 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain CO_dh PF02552.16 EPA06046.1 - 0.014 15.2 0.1 0.035 13.9 0.1 1.7 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit AAA-ATPase_like PF09820.9 EPA06046.1 - 0.18 11.2 1.7 3.7 6.9 0.5 2.2 2 0 0 2 2 2 0 Predicted AAA-ATPase PvlArgDC PF01862.16 EPA06049.1 - 1e-56 191.2 0.0 1.2e-56 191.0 0.0 1.0 1 0 0 1 1 1 1 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) KIP1 PF07765.12 EPA06050.1 - 0.43 10.7 7.9 0.08 13.1 2.9 2.1 1 1 1 2 2 2 0 KIP1-like protein DUF5514 PF17633.2 EPA06050.1 - 1.3 9.3 8.4 3.1 8.0 8.6 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5514) Shugoshin_N PF07558.11 EPA06050.1 - 2.2 8.2 14.1 0.24 11.3 6.4 2.8 2 2 0 2 2 2 0 Shugoshin N-terminal coiled-coil region AsnC_trans_reg PF01037.21 EPA06051.1 - 2.3e-08 33.9 0.1 2.4e-08 33.8 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain GYD PF08734.11 EPA06051.1 - 7e-05 22.7 0.1 7.7e-05 22.6 0.1 1.1 1 0 0 1 1 1 1 GYD domain RecO_N_2 PF13114.6 EPA06051.1 - 0.0023 17.6 0.1 0.0028 17.3 0.1 1.1 1 0 0 1 1 1 1 RecO N terminal Pyrophosphatase PF00719.19 EPA06052.1 - 7.6e-56 188.3 0.1 8.9e-56 188.1 0.1 1.0 1 0 0 1 1 1 1 Inorganic pyrophosphatase Response_reg PF00072.24 EPA06053.1 - 1.3e-12 47.9 0.0 1.5e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain YnfE PF17452.2 EPA06053.1 - 0.001 19.3 0.0 0.056 13.7 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized YnfE-like BRCT_3 PF18428.1 EPA06053.1 - 0.12 12.4 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Coiled-coil_56 PF09813.9 EPA06054.1 - 0.061 13.4 0.1 0.21 11.7 0.0 1.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 56 CBS PF00571.28 EPA06055.1 - 3.8e-36 123.3 10.8 2e-09 37.7 0.0 4.3 4 0 0 4 4 4 4 CBS domain Usp PF00582.26 EPA06056.1 - 2.1e-12 47.8 0.0 2.3e-12 47.6 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family Amidohydro_2 PF04909.14 EPA06057.1 - 5.2e-34 118.4 0.0 5.9e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase Trp_syntA PF00290.20 EPA06057.1 - 0.048 12.5 0.0 0.11 11.3 0.0 1.6 2 0 0 2 2 2 0 Tryptophan synthase alpha chain DEAD PF00270.29 EPA06058.1 - 2.1e-50 170.9 0.1 1.2e-49 168.5 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EPA06058.1 - 7.5e-31 106.7 0.0 1.7e-29 102.4 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EPA06058.1 - 1.2e-05 24.7 0.2 1.8e-05 24.1 0.2 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EPA06058.1 - 0.00046 20.2 0.0 0.00078 19.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EPA06058.1 - 0.0012 18.6 0.1 0.0026 17.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.6 EPA06058.1 - 0.0099 15.2 0.1 0.036 13.4 0.1 1.9 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Flavi_DEAD PF07652.14 EPA06058.1 - 0.12 12.4 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain Helicase_RecD PF05127.14 EPA06058.1 - 0.16 11.8 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 Helicase FSAP_sig_propep PF03032.15 EPA06059.1 - 4.6 7.3 5.1 0.87 9.7 1.4 1.6 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide SHOCT PF09851.9 EPA06060.1 - 7.9e-08 31.8 4.3 1.8e-07 30.7 4.3 1.7 1 0 0 1 1 1 1 Short C-terminal domain Peptidase_M3 PF01432.20 EPA06062.1 - 8.5e-46 157.2 0.7 5.2e-45 154.5 0.7 2.1 1 1 0 1 1 1 1 Peptidase family M3 Peptidase_M3_N PF08439.10 EPA06062.1 - 1.4e-05 25.2 5.5 2.9e-05 24.2 0.2 4.0 4 1 0 4 4 4 1 Oligopeptidase F Peptidase_M78 PF06114.13 EPA06062.1 - 0.0031 17.4 0.1 0.0087 16.0 0.1 1.8 1 1 0 1 1 1 1 IrrE N-terminal-like domain Colicin PF01024.19 EPA06062.1 - 0.096 12.6 2.7 0.58 10.0 0.3 2.5 2 0 0 2 2 2 0 Colicin pore forming domain FG-GAP_2 PF14312.6 EPA06062.1 - 0.14 12.4 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 FG-GAP repeat DUF3198 PF11433.8 EPA06062.1 - 0.29 11.0 4.2 7.8 6.5 0.4 3.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3198) Acyl_transf_3 PF01757.22 EPA06063.1 - 0.14 11.2 24.7 0.19 10.8 14.8 2.1 1 1 1 2 2 2 0 Acyltransferase family YhfC PF10086.9 EPA06063.1 - 4.9 6.4 7.5 2.1 7.7 1.4 2.2 2 0 0 2 2 2 0 YhfC intramembrane metalloprotease DUF1059 PF06348.11 EPA06065.1 - 3.4e-07 30.4 0.1 3.8e-07 30.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) FliG_N PF14842.6 EPA06065.1 - 0.056 14.0 0.1 0.061 13.9 0.1 1.1 1 0 0 1 1 1 0 FliG N-terminal domain AAA_lid_9 PF17871.1 EPA06065.1 - 0.076 12.9 0.1 0.087 12.8 0.1 1.1 1 0 0 1 1 1 0 AAA lid domain MS_channel PF00924.18 EPA06066.1 - 4.3e-28 98.3 0.0 9.8e-28 97.1 0.0 1.6 1 0 0 1 1 1 1 Mechanosensitive ion channel DUF1774 PF08611.10 EPA06066.1 - 0.028 14.7 0.6 0.087 13.1 0.6 1.8 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1774) LMF1 PF06762.14 EPA06066.1 - 0.1 11.7 0.6 0.16 11.1 0.6 1.2 1 0 0 1 1 1 0 Lipase maturation factor Ninjurin PF04923.12 EPA06066.1 - 0.24 11.3 1.7 1.8 8.6 1.8 2.1 2 0 0 2 2 2 0 Ninjurin LIM PF00412.22 EPA06067.1 - 0.022 15.0 3.0 0.03 14.5 3.0 1.2 1 0 0 1 1 1 0 LIM domain XPA_N PF01286.18 EPA06067.1 - 0.033 14.2 4.6 0.19 11.8 5.0 1.8 1 1 1 2 2 2 0 XPA protein N-terminal zinc_ribbon_6 PF14599.6 EPA06068.1 - 0.0056 16.7 1.9 0.015 15.3 2.0 1.7 1 1 1 2 2 2 1 Zinc-ribbon OrfB_Zn_ribbon PF07282.11 EPA06068.1 - 0.27 11.2 3.1 0.35 10.8 3.1 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Glyco_hydro_44 PF12891.7 EPA06069.1 - 0.023 14.6 0.7 0.036 14.0 0.7 1.4 1 1 0 1 1 1 0 Glycoside hydrolase family 44 Acetyltransf_9 PF13527.7 EPA06070.1 - 1.3e-07 31.7 0.0 0.0011 19.1 0.0 2.2 1 1 1 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EPA06070.1 - 1.5e-07 31.7 0.0 2.1e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EPA06070.1 - 0.0016 18.9 0.0 0.0051 17.2 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Phage_integr_3 PF16795.5 EPA06071.1 - 2.6e-06 27.5 0.1 5.2e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 Archaeal phage integrase DUF1444 PF07285.11 EPA06072.1 - 0.06 12.9 0.4 1.1 8.8 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1444) DUF4488 PF14869.6 EPA06072.1 - 0.076 12.9 0.5 0.13 12.2 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4488) ZapA PF05164.13 EPA06072.1 - 0.13 12.7 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 Cell division protein ZapA BSMAP PF12280.8 EPA06073.1 - 6.5 6.9 9.3 16 5.6 4.1 2.6 1 1 1 2 2 2 0 Brain specific membrane anchored protein Rax2 PF12768.7 EPA06074.1 - 0.0011 18.5 4.2 0.0033 16.9 4.2 1.9 1 1 0 1 1 1 1 Cortical protein marker for cell polarity MuF_C PF18819.1 EPA06074.1 - 0.085 12.8 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 Phage MuF-C-terminal domain DUF919 PF06034.11 EPA06074.1 - 0.18 11.7 1.4 0.25 11.2 0.4 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) MotCF PF09158.10 EPA06074.1 - 2.8 8.0 6.5 15 5.7 0.7 2.7 1 1 1 2 2 2 0 Bacteriophage T4 MotA, C-terminal TrbI PF03743.14 EPA06077.1 - 0.081 12.8 11.8 0.089 12.6 11.8 1.1 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein SOXp PF12336.8 EPA06077.1 - 0.63 11.1 7.3 0.77 10.9 7.3 1.1 1 0 0 1 1 1 0 SOX transcription factor Response_reg PF00072.24 EPA06078.1 - 5.5e-25 87.7 1.8 1.9e-24 86.0 1.8 2.0 1 0 0 1 1 1 1 Response regulator receiver domain TrmB PF01978.19 EPA06078.1 - 5.1e-14 51.9 0.1 1.6e-13 50.3 0.0 1.9 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 EPA06078.1 - 1.5e-05 24.3 1.4 2e-05 23.9 0.6 1.6 2 0 0 2 2 2 1 Archaeal transcriptional regulator TrmB DisA-linker PF10635.9 EPA06078.1 - 0.3 10.9 6.9 2.3 8.0 0.4 3.2 4 0 0 4 4 4 0 DisA bacterial checkpoint controller linker region HATPase_c PF02518.26 EPA06079.1 - 1.9e-19 70.2 0.0 4.3e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 EPA06079.1 - 4.5e-10 39.3 0.1 1e-08 35.0 0.0 2.8 2 1 0 2 2 2 1 GHKL domain HisKA PF00512.25 EPA06079.1 - 3.4e-09 36.6 0.2 1.3e-08 34.7 0.2 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 EPA06079.1 - 5.6e-09 36.2 0.0 1.6e-08 34.7 0.0 1.9 1 0 0 1 1 1 1 HAMP domain 4HB_MCP_1 PF12729.7 EPA06079.1 - 5.4e-05 22.8 8.7 5.4e-05 22.8 8.7 3.4 2 2 0 2 2 2 1 Four helix bundle sensory module for signal transduction Sigma_reg_N PF13800.6 EPA06079.1 - 0.15 12.3 0.2 0.15 12.3 0.2 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal HisG PF01634.18 EPA06083.1 - 3.4e-44 150.6 0.0 4.3e-44 150.3 0.0 1.1 1 0 0 1 1 1 1 ATP phosphoribosyltransferase Histidinol_dh PF00815.20 EPA06084.1 - 3.3e-113 378.8 0.1 3.7e-113 378.6 0.0 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase ssDNA_DBD PF18333.1 EPA06084.1 - 0.023 14.8 0.0 0.038 14.1 0.0 1.4 1 0 0 1 1 1 0 Non-canonical single-stranded DNA-binding domain CelTOS PF18659.1 EPA06084.1 - 0.15 12.5 0.2 0.15 12.5 0.2 2.0 2 0 0 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites Hydrolase PF00702.26 EPA06085.1 - 4.1e-05 24.0 0.0 0.33 11.2 0.0 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EPA06085.1 - 0.00075 19.6 3.6 0.16 12.1 3.6 2.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Histidinol_dh PF00815.20 EPA06086.1 - 5e-10 38.9 0.9 5.7e-10 38.8 0.9 1.1 1 0 0 1 1 1 1 Histidinol dehydrogenase Aminotran_1_2 PF00155.21 EPA06088.1 - 8.3e-45 153.5 0.0 9.9e-45 153.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EPA06088.1 - 0.0016 17.4 0.0 0.15 11.0 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V LYTB PF02401.18 EPA06088.1 - 0.05 12.9 0.0 0.1 11.8 0.0 1.5 1 0 0 1 1 1 0 LytB protein HTH_22 PF13309.6 EPA06088.1 - 0.12 12.5 0.1 0.51 10.5 0.1 2.1 2 0 0 2 2 2 0 HTH domain HD_4 PF13328.6 EPA06089.1 - 6.8e-17 61.6 0.0 8.6e-17 61.3 0.0 1.1 1 0 0 1 1 1 1 HD domain AalphaY_MDB PF04611.12 EPA06089.1 - 0.064 13.3 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Mating type protein A alpha Y mating type dependent binding region Y_Y_Y PF07495.13 EPA06091.1 - 0.089 12.8 0.1 0.13 12.2 0.1 1.7 1 1 0 1 1 1 0 Y_Y_Y domain Spc29 PF17082.5 EPA06092.1 - 0.049 13.5 0.5 0.049 13.5 0.5 1.0 1 0 0 1 1 1 0 Spindle Pole Component 29 Vir_act_alpha_C PF10400.9 EPA06092.1 - 0.055 14.1 0.4 0.055 14.1 0.4 1.1 1 0 0 1 1 1 0 Virulence activator alpha C-term MAF_flag10 PF01973.18 EPA06093.1 - 1.8e-25 89.6 0.3 2.4e-25 89.2 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF115 Anticodon_1 PF08264.13 EPA06094.1 - 9.5e-18 64.6 0.2 1.6e-17 63.9 0.2 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA RibD_C PF01872.17 EPA06095.1 - 5.6e-18 65.5 0.4 1.6e-15 57.4 0.4 2.1 1 1 0 1 1 1 1 RibD C-terminal domain DHFR_1 PF00186.19 EPA06095.1 - 7.3e-08 32.3 0.0 8.2e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase CAP PF00188.26 EPA06096.1 - 4.1e-19 69.7 1.9 6.7e-19 69.0 0.9 1.9 2 1 0 2 2 2 1 Cysteine-rich secretory protein family ArfGap PF01412.18 EPA06096.1 - 0.11 12.6 0.7 0.43 10.7 0.0 2.2 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Ephrin_rec_like PF07699.13 EPA06096.1 - 0.12 12.2 0.9 0.23 11.3 0.9 1.5 1 0 0 1 1 1 0 Putative ephrin-receptor like Chlorosome_CsmC PF11098.8 EPA06096.1 - 0.12 12.3 0.9 0.25 11.3 0.9 1.5 1 0 0 1 1 1 0 Chlorosome envelope protein C Prominin PF05478.11 EPA06096.1 - 0.26 9.2 2.0 0.65 7.9 1.2 1.6 1 1 0 1 1 1 0 Prominin DUF45 PF01863.17 EPA06097.1 - 1.4e-36 126.5 5.3 1.5e-36 126.4 5.3 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF45 WLM PF08325.10 EPA06097.1 - 1.2e-05 25.4 4.1 1.8e-05 24.9 3.5 1.5 1 1 0 1 1 1 1 WLM domain SprT-like PF10263.9 EPA06097.1 - 0.0048 16.7 0.7 0.008 16.0 0.6 1.5 1 1 0 1 1 1 1 SprT-like family WavE PF07507.11 EPA06097.1 - 0.0073 15.5 2.6 0.0081 15.4 2.6 1.1 1 0 0 1 1 1 1 WavE lipopolysaccharide synthesis Peptidase_M64 PF09471.10 EPA06097.1 - 0.014 14.9 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 IgA Peptidase M64 HTH_6 PF01418.17 EPA06097.1 - 0.036 14.1 0.4 0.89 9.6 0.0 2.4 2 1 0 2 2 2 0 Helix-turn-helix domain, rpiR family Zincin_2 PF10103.9 EPA06097.1 - 0.091 12.0 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Zincin-like metallopeptidase DUF4208 PF13907.6 EPA06097.1 - 0.11 12.9 3.6 0.12 12.8 1.8 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4208) Peptidase_M57 PF12388.8 EPA06098.1 - 0.00053 19.7 0.4 0.0013 18.4 0.4 1.6 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Reprolysin_5 PF13688.6 EPA06098.1 - 0.0088 16.2 0.4 0.019 15.1 0.4 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Pex14_N PF04695.13 EPA06099.1 - 0.26 11.9 4.6 0.37 11.4 4.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Trypan_PARP PF05887.11 EPA06099.1 - 0.56 10.2 13.7 0.86 9.6 13.7 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Phage_Gp15 PF06854.11 EPA06100.1 - 0.024 14.6 0.2 0.024 14.6 0.2 1.0 1 0 0 1 1 1 0 Bacteriophage Gp15 protein DUF72 PF01904.18 EPA06101.1 - 2.1e-45 155.5 0.0 2.6e-45 155.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF72 HSDR_N_2 PF13588.6 EPA06102.1 - 0.0012 18.8 0.2 0.0026 17.7 0.1 1.6 1 1 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) DUF234 PF03008.14 EPA06102.1 - 0.016 15.7 1.4 0.019 15.4 0.5 1.7 2 0 0 2 2 2 0 Archaea bacterial proteins of unknown function DUF5625 PF18539.1 EPA06102.1 - 0.016 15.5 2.8 0.026 14.8 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5625) TPR_8 PF13181.6 EPA06103.1 - 0.00089 19.3 0.1 0.018 15.2 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EPA06103.1 - 0.0027 18.0 0.1 0.022 15.1 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EPA06103.1 - 0.0097 16.5 0.1 6 7.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat G8 PF10162.9 EPA06103.1 - 0.013 15.6 0.0 0.022 14.8 0.0 1.4 1 0 0 1 1 1 0 G8 domain TPR_2 PF07719.17 EPA06103.1 - 0.015 15.3 0.2 0.2 11.8 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EPA06103.1 - 0.035 14.4 0.0 0.062 13.6 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3808 PF10300.9 EPA06103.1 - 0.082 11.6 0.1 0.11 11.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) 2_5_RNA_ligase2 PF13563.6 EPA06104.1 - 6.3e-16 58.6 0.0 9.8e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily Ribosomal_L35p PF01632.19 EPA06104.1 - 0.06 13.9 0.2 0.12 12.9 0.2 1.5 1 0 0 1 1 1 0 Ribosomal protein L35 IMPDH PF00478.25 EPA06105.1 - 8e-97 324.3 9.7 8.9e-97 324.2 9.7 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EPA06105.1 - 2.5e-07 30.4 1.1 0.0036 16.8 0.1 2.3 1 1 1 2 2 2 2 Histidine biosynthesis protein FMN_dh PF01070.18 EPA06105.1 - 2.7e-07 29.9 4.0 3e-07 29.8 3.1 1.5 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 EPA06105.1 - 4.6e-05 23.0 7.0 8.8e-05 22.0 7.0 1.4 1 1 0 1 1 1 1 Nitronate monooxygenase DHO_dh PF01180.21 EPA06105.1 - 0.00016 21.0 5.1 0.00036 19.9 1.3 2.1 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase NanE PF04131.14 EPA06105.1 - 0.00032 20.0 1.8 0.00062 19.0 1.8 1.5 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase PEP_mutase PF13714.6 EPA06105.1 - 0.0064 16.0 0.5 0.02 14.3 0.1 1.8 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase PK PF00224.21 EPA06105.1 - 0.0067 15.4 0.0 0.0083 15.0 0.0 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain BATS PF06968.13 EPA06105.1 - 0.017 15.2 0.1 6.9 6.9 0.1 2.6 2 1 0 2 2 2 0 Biotin and Thiamin Synthesis associated domain Aldolase PF01081.19 EPA06105.1 - 0.022 14.2 0.9 0.054 12.9 0.4 1.8 1 1 1 2 2 2 0 KDPG and KHG aldolase ThiG PF05690.14 EPA06105.1 - 0.022 14.1 2.1 0.027 13.8 0.5 1.8 1 1 0 2 2 2 0 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 EPA06105.1 - 0.029 13.5 3.5 0.042 13.0 3.5 1.3 1 0 0 1 1 1 0 Conserved region in glutamate synthase G3P_antiterm PF04309.12 EPA06105.1 - 0.041 13.3 1.1 1.7 8.0 0.1 2.3 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator QRPTase_C PF01729.19 EPA06105.1 - 0.045 13.5 0.2 0.27 11.0 0.1 2.1 2 1 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain B12-binding PF02310.19 EPA06105.1 - 0.062 13.3 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 B12 binding domain Radical_SAM PF04055.21 EPA06105.1 - 0.18 12.2 0.0 16 5.8 0.0 2.3 1 1 1 2 2 2 0 Radical SAM superfamily ATP-sulfurylase PF01747.17 EPA06106.1 - 1.5e-26 93.2 0.0 1.7e-26 93.0 0.0 1.0 1 0 0 1 1 1 1 ATP-sulfurylase DUF3493 PF11998.8 EPA06110.1 - 0.098 12.8 0.1 0.14 12.4 0.1 1.3 1 1 0 1 1 1 0 Low psii accumulation1 / Rep27 DZR PF12773.7 EPA06111.1 - 0.041 13.9 9.0 0.097 12.7 9.0 1.5 1 1 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 EPA06111.1 - 0.12 12.3 11.3 0.74 9.8 8.7 2.0 1 1 1 2 2 2 0 zinc-ribbons PolC_DP2 PF03833.13 EPA06111.1 - 0.59 7.9 8.4 0.63 7.8 8.4 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 C1_2 PF03107.16 EPA06111.1 - 1.4 9.3 13.2 1.2 9.5 9.7 2.1 1 1 1 2 2 2 0 C1 domain SelR PF01641.18 EPA06112.1 - 3.5e-55 185.3 0.3 3.9e-55 185.1 0.3 1.0 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.14 EPA06112.1 - 0.005 17.0 3.0 0.015 15.5 2.2 2.0 1 1 1 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HECT_2 PF09814.9 EPA06112.1 - 0.0071 15.2 1.2 0.7 8.7 0.1 2.0 1 1 1 2 2 2 2 HECT-like Ubiquitin-conjugating enzyme (E2)-binding ADK_lid PF05191.14 EPA06112.1 - 0.22 11.5 4.3 1.4 9.0 0.7 2.5 2 0 0 2 2 2 0 Adenylate kinase, active site lid DUF983 PF06170.12 EPA06112.1 - 0.24 11.9 2.5 5 7.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Ephrin_rec_like PF07699.13 EPA06113.1 - 0.0036 17.0 3.0 0.0047 16.7 3.0 1.4 1 1 0 1 1 1 1 Putative ephrin-receptor like GCD14 PF08704.10 EPA06115.1 - 1.6e-35 123.0 0.1 3.7e-35 121.8 0.1 1.5 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 EPA06115.1 - 2.8e-09 37.0 0.1 3.9e-09 36.6 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EPA06115.1 - 1.3e-08 34.8 0.0 1.9e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EPA06115.1 - 1.1e-06 28.2 0.1 1.8e-06 27.5 0.1 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EPA06115.1 - 3.3e-06 27.7 0.0 6.2e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 EPA06115.1 - 7.9e-05 23.6 0.0 0.00019 22.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EPA06115.1 - 0.00015 21.3 0.0 0.00019 20.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 EPA06115.1 - 0.00025 20.8 0.0 0.00045 20.0 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_12 PF08242.12 EPA06115.1 - 0.0003 21.5 0.0 0.00094 19.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Fibrillarin PF01269.17 EPA06115.1 - 0.00039 19.6 0.0 0.0006 19.0 0.0 1.4 1 0 0 1 1 1 1 Fibrillarin Methyltransf_3 PF01596.17 EPA06115.1 - 0.00039 19.7 0.1 0.00058 19.1 0.1 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_11 PF08241.12 EPA06115.1 - 0.0004 21.0 0.0 0.00083 20.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 EPA06115.1 - 0.00046 19.3 0.0 0.00078 18.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltr_RsmB-F PF01189.17 EPA06115.1 - 0.0005 19.8 0.0 0.00079 19.1 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F MTS PF05175.14 EPA06115.1 - 0.002 17.7 0.0 0.0046 16.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain GCD14_N PF14801.6 EPA06115.1 - 0.0074 16.1 0.7 0.021 14.7 0.0 2.0 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_18 PF12847.7 EPA06115.1 - 0.019 14.9 0.0 0.034 14.1 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EPA06115.1 - 0.023 14.0 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DUF938 PF06080.12 EPA06115.1 - 0.023 14.4 0.0 0.035 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) UPF0020 PF01170.18 EPA06115.1 - 0.1 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_23 PF13489.6 EPA06115.1 - 0.17 11.7 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PQQ_3 PF13570.6 EPA06116.1 - 0.24 12.0 0.1 0.24 12.0 0.1 3.8 3 1 0 3 3 3 0 PQQ-like domain Carb_kinase PF01256.17 EPA06117.1 - 1.3e-47 162.3 0.5 1.5e-47 162.1 0.5 1.0 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 EPA06117.1 - 1.3e-09 37.8 0.1 2.3e-09 37.0 0.1 1.3 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.12 EPA06117.1 - 1.2e-05 24.9 0.1 1.6e-05 24.4 0.1 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Cation_ATPase PF13246.6 EPA06117.1 - 0.17 12.0 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Cation transport ATPase (P-type) AMP-binding PF00501.28 EPA06119.1 - 1.2e-95 320.6 0.0 1.5e-95 320.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EPA06119.1 - 6.6e-25 87.9 0.3 2.4e-24 86.1 0.1 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EPA06119.1 - 8.3e-15 54.4 6.4 2.4e-14 53.0 6.4 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Peptidase_M20 PF01546.28 EPA06121.1 - 2.4e-32 112.3 0.0 3.3e-32 111.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EPA06121.1 - 1.7e-14 53.6 0.0 3.6e-14 52.6 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Ribosomal_S21 PF01165.20 EPA06121.1 - 0.094 12.5 0.0 6.1 6.6 0.1 2.4 2 0 0 2 2 2 0 Ribosomal protein S21 DUF5368 PF17336.2 EPA06122.1 - 0.012 15.8 2.1 0.013 15.7 2.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5368) SfLAP PF11139.8 EPA06122.1 - 0.028 13.9 0.7 0.03 13.8 0.7 1.0 1 0 0 1 1 1 0 Sap, sulfolipid-1-addressing protein VIT1 PF01988.19 EPA06122.1 - 0.096 12.5 1.3 0.12 12.3 1.3 1.0 1 0 0 1 1 1 0 VIT family Tetraspanin PF00335.20 EPA06122.1 - 0.7 9.6 5.9 0.82 9.3 5.9 1.0 1 0 0 1 1 1 0 Tetraspanin family DUF3040 PF11239.8 EPA06122.1 - 9.7 6.5 6.7 2.2e+02 2.2 6.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3040) SWIRM-assoc_1 PF16495.5 EPA06123.1 - 0.037 14.0 0.5 0.051 13.5 0.5 1.2 1 0 0 1 1 1 0 SWIRM-associated region 1 FB_lectin PF07367.11 EPA06123.1 - 0.093 12.7 1.4 0.11 12.5 1.4 1.1 1 0 0 1 1 1 0 Fungal fruit body lectin DUF3008 PF11450.8 EPA06123.1 - 0.1 12.8 0.8 0.16 12.2 0.1 1.6 2 0 0 2 2 2 0 Protein of unknwon function (DUF3008) SWIRM PF04433.17 EPA06123.1 - 0.13 12.7 2.8 2.1 8.7 0.4 2.2 1 1 1 2 2 2 0 SWIRM domain Mst1_SARAH PF11629.8 EPA06123.1 - 0.15 12.2 4.0 0.21 11.7 1.9 2.2 2 1 1 3 3 3 0 C terminal SARAH domain of Mst1 DUF4817 PF16087.5 EPA06123.1 - 0.34 10.8 3.8 11 5.9 1.1 2.6 1 1 1 2 2 2 0 Helix-turn-helix domain (DUF4817) Hydrolase_3 PF08282.12 EPA06124.1 - 2.2e-30 106.3 2.7 1.8e-21 77.1 0.2 2.0 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EPA06124.1 - 1.3e-07 31.4 0.1 0.00051 19.6 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Trehalose_PPase PF02358.16 EPA06124.1 - 2.3e-07 30.2 0.1 0.00011 21.5 0.1 2.3 1 1 0 1 1 1 1 Trehalose-phosphatase Hydrolase PF00702.26 EPA06124.1 - 4.1e-05 24.0 0.6 0.019 15.3 0.0 2.6 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EPA06124.1 - 0.015 15.7 0.3 0.17 12.3 0.0 2.3 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EPA06124.1 - 0.029 14.5 0.5 0.1 12.6 0.0 2.2 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase MJ1316 PF04457.12 EPA06126.1 - 0.00018 22.2 0.1 0.00024 21.8 0.1 1.1 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain HicB-like_2 PF15970.5 EPA06126.1 - 0.049 13.8 0.0 0.057 13.6 0.0 1.3 1 0 0 1 1 1 0 HicB_like antitoxin of bacterial toxin-antitoxin system YvbH_ext PF11724.8 EPA06127.1 - 0.022 15.1 0.2 0.053 13.8 0.2 1.8 1 0 0 1 1 1 0 YvbH-like oligomerisation region PUA PF01472.20 EPA06128.1 - 2.6e-16 59.4 0.6 3.6e-16 58.9 0.6 1.2 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EPA06128.1 - 0.031 14.5 0.1 0.052 13.8 0.1 1.4 1 0 0 1 1 1 0 UPF0113 PUA domain XPG_I PF00867.18 EPA06129.1 - 6.2e-24 84.2 0.0 1.5e-23 83.0 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EPA06129.1 - 2.1e-21 76.3 0.0 8.4e-21 74.4 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EPA06129.1 - 0.00057 20.4 0.0 0.0019 18.7 0.0 1.9 1 1 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold DUF4878 PF12870.7 EPA06129.1 - 0.31 11.3 2.4 0.27 11.5 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4878) DoxX PF07681.12 EPA06130.1 - 2.5e-14 53.6 6.4 2.5e-14 53.6 6.4 1.7 2 0 0 2 2 2 1 DoxX DoxD PF04173.13 EPA06130.1 - 2.9e-06 27.3 6.7 6.8e-06 26.1 6.4 1.6 1 1 1 2 2 2 1 TQO small subunit DoxD DoxX_2 PF13564.6 EPA06130.1 - 1.1e-05 25.5 7.5 1.9e-05 24.7 7.5 1.5 1 1 0 1 1 1 1 DoxX-like family Band_7 PF01145.25 EPA06131.1 - 1.4e-23 83.9 6.5 2.2e-23 83.1 6.5 1.4 1 1 0 1 1 1 1 SPFH domain / Band 7 family CdiA_C PF18451.1 EPA06131.1 - 0.082 13.1 0.5 0.17 12.1 0.5 1.5 1 0 0 1 1 1 0 Contact-dependent growth inhibition CdiA C-terminal domain Fer4_21 PF14697.6 EPA06132.1 - 0.022 14.9 2.1 0.026 14.6 2.1 1.1 1 0 0 1 1 1 0 4Fe-4S dicluster domain TrmB PF01978.19 EPA06133.1 - 0.00043 20.1 0.0 0.0006 19.7 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HxlR PF01638.17 EPA06133.1 - 0.0017 18.2 0.0 0.0022 17.8 0.0 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix TFIIE_alpha PF02002.17 EPA06133.1 - 0.015 15.2 0.1 0.019 14.8 0.1 1.1 1 0 0 1 1 1 0 TFIIE alpha subunit GntR PF00392.21 EPA06133.1 - 0.098 12.3 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family Homoserine_dh PF00742.19 EPA06135.1 - 1.4e-54 184.7 0.2 2.2e-54 184.0 0.2 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 EPA06135.1 - 3e-07 31.1 0.0 6.5e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 EPA06135.1 - 3.6e-07 30.1 0.2 9.7e-07 28.8 0.2 1.6 1 1 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase PAS_9 PF13426.7 EPA06136.1 - 6.9e-10 39.1 0.0 1.1e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EPA06136.1 - 6.4e-09 35.8 0.0 8.2e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 EPA06136.1 - 1.3e-05 25.4 0.0 2.1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EPA06136.1 - 0.00033 20.9 0.0 0.00041 20.6 0.0 1.1 1 0 0 1 1 1 1 PAS fold PheRS_DBD2 PF18554.1 EPA06136.1 - 0.66 10.0 4.4 0.19 11.8 0.9 2.0 2 0 0 2 2 2 0 PheRS DNA binding domain 2 TerC PF03741.16 EPA06138.1 - 1e-49 168.7 13.8 1e-49 168.7 13.8 2.4 3 0 0 3 3 3 2 Integral membrane protein TerC family MMR_HSR1_Xtn PF16897.5 EPA06139.1 - 4.9e-29 100.5 3.9 9.6e-29 99.5 3.9 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EPA06139.1 - 1.9e-22 79.5 0.3 4.8e-22 78.2 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 EPA06139.1 - 4.5e-21 74.7 0.1 1.3e-20 73.2 0.0 1.9 2 0 0 2 2 2 1 TGS domain FeoB_N PF02421.18 EPA06139.1 - 7e-15 54.9 2.0 9.9e-13 47.9 0.0 2.4 2 1 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EPA06139.1 - 6.4e-06 26.2 1.5 0.0091 15.9 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 EPA06139.1 - 0.00041 20.4 1.5 0.54 10.3 0.1 2.9 2 1 1 3 3 3 2 Dynamin family MnmE_helical PF12631.7 EPA06139.1 - 0.00052 20.2 0.1 0.00067 19.9 0.1 1.1 1 0 0 1 1 1 1 MnmE helical domain AIG1 PF04548.16 EPA06139.1 - 0.0013 18.1 0.0 0.0025 17.2 0.0 1.4 1 0 0 1 1 1 1 AIG1 family cobW PF02492.19 EPA06139.1 - 0.0019 17.8 1.0 0.096 12.3 0.1 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Arf PF00025.21 EPA06139.1 - 0.0031 17.0 1.6 0.038 13.4 0.0 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 EPA06139.1 - 0.0057 16.1 0.9 0.008 15.6 0.1 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EPA06139.1 - 0.023 14.9 0.1 0.13 12.5 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EPA06139.1 - 0.025 14.8 0.1 0.051 13.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EPA06139.1 - 0.029 14.8 0.4 0.18 12.2 0.1 2.3 1 1 0 2 2 2 0 AAA ATPase domain Ras PF00071.22 EPA06139.1 - 0.068 12.8 1.2 4.8 6.8 0.0 2.3 2 0 0 2 2 2 0 Ras family AAA_33 PF13671.6 EPA06139.1 - 0.097 12.8 0.1 0.22 11.7 0.1 1.6 1 0 0 1 1 1 0 AAA domain SAC3 PF12209.8 EPA06141.1 - 0.0083 16.3 0.0 0.059 13.6 0.1 2.1 2 0 0 2 2 2 1 Leucine permease transcriptional regulator helical domain YodL PF14191.6 EPA06141.1 - 0.024 15.5 0.8 0.03 15.2 0.8 1.1 1 0 0 1 1 1 0 YodL-like CENP-B_N PF04218.13 EPA06141.1 - 0.14 11.8 0.7 3.6 7.3 0.0 2.7 3 0 0 3 3 3 0 CENP-B N-terminal DNA-binding domain DALR_1 PF05746.15 EPA06143.1 - 6.8e-28 97.2 0.1 3.8e-27 94.8 0.0 2.3 3 0 0 3 3 3 1 DALR anticodon binding domain tRNA-synt_1d PF00750.19 EPA06143.1 - 1e-25 90.4 6.2 5.2e-21 75.0 0.4 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (R) Arg_tRNA_synt_N PF03485.16 EPA06143.1 - 3.7e-16 59.5 0.1 1e-15 58.1 0.1 1.8 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 EPA06143.1 - 0.0017 17.8 0.2 0.0017 17.8 0.2 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EPA06143.1 - 0.0052 15.6 0.1 0.012 14.4 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1f PF01921.18 EPA06143.1 - 0.039 12.9 0.4 0.13 11.2 0.1 2.0 2 0 0 2 2 2 0 tRNA synthetases class I (K) PNPase PF03726.14 EPA06143.1 - 2.3 8.8 5.8 16 6.1 0.4 3.3 3 0 0 3 3 3 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain CdvA PF18822.1 EPA06144.1 - 8.5e-35 119.3 10.3 1.4e-34 118.6 10.3 1.3 1 0 0 1 1 1 1 CdvA-like coiled-coil domain Fes1 PF08609.10 EPA06144.1 - 0.014 16.2 3.5 0.021 15.7 0.6 2.3 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 AAA_13 PF13166.6 EPA06144.1 - 0.029 13.0 10.6 0.039 12.6 10.6 1.1 1 0 0 1 1 1 0 AAA domain FliT PF05400.13 EPA06144.1 - 0.045 14.6 8.7 0.7 10.7 0.1 2.7 2 1 0 2 2 2 0 Flagellar protein FliT CBFD_NFYB_HMF PF00808.23 EPA06144.1 - 0.055 13.8 0.2 0.13 12.6 0.2 1.6 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Baculo_PEP_C PF04513.12 EPA06144.1 - 0.082 12.9 0.7 0.18 11.9 0.7 1.6 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus MutS_III PF05192.18 EPA06144.1 - 1.1 9.5 4.6 1.7 8.8 4.6 1.3 1 0 0 1 1 1 0 MutS domain III DUF4407 PF14362.6 EPA06144.1 - 1.8 7.8 6.1 3.4 6.9 6.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) MerR-DNA-bind PF09278.11 EPA06144.1 - 6.1 7.4 8.0 10 6.8 1.6 3.0 2 1 1 3 3 3 0 MerR, DNA binding HTH_20 PF12840.7 EPA06145.1 - 6.7e-07 29.3 0.2 2.8e-06 27.3 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.7 EPA06145.1 - 3.4e-06 26.8 0.0 0.00071 19.4 0.0 2.3 2 0 0 2 2 2 1 MarR family DUF4423 PF14394.6 EPA06145.1 - 5.1e-05 23.0 0.2 0.00019 21.2 0.0 2.0 2 1 1 3 3 3 1 Domain of unknown function (DUF4423) HTH_Crp_2 PF13545.6 EPA06145.1 - 0.0026 17.7 0.1 0.015 15.3 0.0 2.1 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain MarR PF01047.22 EPA06145.1 - 0.0027 17.6 0.5 3.5 7.6 0.0 3.1 3 0 0 3 3 3 2 MarR family HTH_5 PF01022.20 EPA06145.1 - 0.0042 16.9 0.1 0.015 15.2 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family DUF2250 PF10007.9 EPA06145.1 - 0.0055 16.8 0.3 0.37 10.9 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2250) HTH_45 PF14947.6 EPA06145.1 - 0.014 15.3 1.0 0.12 12.4 0.0 2.5 3 0 0 3 3 3 0 Winged helix-turn-helix DUF3449 PF11931.8 EPA06145.1 - 0.015 15.1 1.1 0.033 14.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) DUF505 PF04458.12 EPA06145.1 - 0.016 13.6 0.0 0.019 13.4 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF505) DUF1724 PF08350.10 EPA06145.1 - 0.024 14.8 0.4 0.05 13.8 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1724) HTH_24 PF13412.6 EPA06145.1 - 0.029 13.9 0.2 0.29 10.7 0.0 2.4 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding TrmB PF01978.19 EPA06145.1 - 0.059 13.3 0.0 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Thy1 PF02511.15 EPA06146.1 - 1.9e-34 119.1 1.8 1.7e-18 67.1 2.3 2.3 2 0 0 2 2 2 2 Thymidylate synthase complementing protein DUF4817 PF16087.5 EPA06146.1 - 0.047 13.5 0.1 0.16 11.8 0.1 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain (DUF4817) Uteroglobin PF01099.17 EPA06146.1 - 2.7 8.4 4.7 20 5.6 0.0 3.6 4 0 0 4 4 4 0 Uteroglobin family FadA PF09403.10 EPA06146.1 - 3.6 8.1 10.4 11 6.6 1.5 3.7 3 0 0 3 3 3 0 Adhesion protein FadA Proteasome PF00227.26 EPA06147.1 - 2.6e-46 157.5 0.0 3.2e-46 157.2 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit PHO4 PF01384.20 EPA06148.1 - 7.8e-91 304.6 39.9 3.6e-90 302.4 39.9 1.8 1 1 0 1 1 1 1 Phosphate transporter family HTH_IclR PF09339.10 EPA06148.1 - 0.078 12.8 0.3 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 IclR helix-turn-helix domain DUF1656 PF07869.12 EPA06148.1 - 0.097 12.7 0.1 0.097 12.7 0.1 4.1 5 0 0 5 5 5 0 Protein of unknown function (DUF1656) DUF726 PF05277.12 EPA06149.1 - 3.1e-10 39.5 0.0 4.5e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) DUF900 PF05990.12 EPA06149.1 - 7.3e-10 38.8 0.0 9.7e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) DUF676 PF05057.14 EPA06149.1 - 9.1e-05 22.1 0.2 0.00017 21.2 0.2 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) LCAT PF02450.15 EPA06149.1 - 0.0011 18.2 0.3 0.0019 17.4 0.0 1.5 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase DUF1749 PF08538.10 EPA06149.1 - 0.0011 18.1 0.0 0.0016 17.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.8 EPA06149.1 - 0.0015 17.9 0.0 0.0031 16.8 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Cutinase PF01083.22 EPA06149.1 - 0.0016 18.4 0.0 0.0022 18.0 0.0 1.2 1 0 0 1 1 1 1 Cutinase LIDHydrolase PF10230.9 EPA06149.1 - 0.0018 17.9 0.2 0.0058 16.2 0.2 1.7 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 EPA06149.1 - 0.0076 16.1 0.0 0.012 15.5 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Say1_Mug180 PF10340.9 EPA06149.1 - 0.054 12.3 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 Steryl acetyl hydrolase PhoU_div PF01865.16 EPA06151.1 - 2.9e-23 82.4 10.8 3.2e-23 82.2 10.8 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF47 ArAE_1_C PF11728.8 EPA06151.1 - 0.15 12.1 4.1 0.29 11.1 2.5 2.1 2 1 0 2 2 2 0 Putative aromatic acid exporter C-terminal domain Med4 PF10018.9 EPA06151.1 - 0.37 10.4 3.0 0.5 10.0 1.3 1.9 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 tRNA-synt_1g PF09334.11 EPA06153.1 - 2.7e-14 52.7 0.2 4.2e-14 52.1 0.2 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EPA06153.1 - 1.1e-07 31.9 0.0 1.4e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA zinc_ribbon_4 PF13717.6 EPA06154.1 - 0.011 15.6 0.5 0.24 11.3 0.2 2.1 2 0 0 2 2 2 0 zinc-ribbon domain NurA PF09376.10 EPA06157.1 - 1.5e-17 64.1 0.1 2.2e-17 63.6 0.1 1.3 1 0 0 1 1 1 1 NurA domain OpuAC PF04069.12 EPA06157.1 - 0.084 12.4 0.0 0.14 11.7 0.0 1.3 1 1 0 1 1 1 0 Substrate binding domain of ABC-type glycine betaine transport system SMC_N PF02463.19 EPA06159.1 - 6.5e-17 61.7 23.2 4.9e-10 39.2 1.3 2.6 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EPA06159.1 - 9e-16 59.0 34.8 9e-16 59.0 34.8 4.2 1 1 1 3 3 1 1 AAA domain AAA_21 PF13304.6 EPA06159.1 - 9e-12 45.4 11.4 2.3e-06 27.6 0.4 3.2 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EPA06159.1 - 1.2e-10 41.7 55.4 1.3e-06 28.4 26.2 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EPA06159.1 - 8.4e-09 35.0 0.2 1.7e-08 34.0 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_27 PF13514.6 EPA06159.1 - 1.1e-06 28.4 0.4 1.1e-06 28.4 0.4 2.7 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.6 EPA06159.1 - 1.1e-05 25.5 0.1 2.3e-05 24.6 0.1 1.5 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 EPA06159.1 - 0.0002 21.9 23.2 0.012 16.2 0.1 5.1 2 1 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 EPA06159.1 - 0.009 15.9 0.1 0.009 15.9 0.1 3.7 3 1 1 4 4 4 1 RsgA GTPase DNA_ligase_ZBD PF03119.16 EPA06159.1 - 0.076 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Pim PF16765.5 EPA06159.1 - 0.15 12.2 2.4 2.6 8.3 0.3 2.7 2 0 0 2 2 2 0 Pesticin immunity protein MukB PF04310.12 EPA06159.1 - 0.28 11.0 0.0 0.28 11.0 0.0 3.4 4 1 0 4 4 4 0 MukB N-terminal MMR_HSR1 PF01926.23 EPA06159.1 - 0.79 9.8 6.3 0.74 9.9 0.1 3.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase Radical_SAM_N PF08497.10 EPA06159.1 - 9.6 5.3 7.8 1.4 8.1 0.3 2.6 2 1 0 2 2 2 0 Radical SAM N-terminal DUF87 PF01935.17 EPA06162.1 - 2.8e-37 129.0 3.3 2.8e-37 129.0 3.3 1.7 2 0 0 2 2 2 1 Helicase HerA, central domain DUF853 PF05872.12 EPA06162.1 - 0.00014 20.6 0.1 0.0097 14.5 0.0 2.1 2 0 0 2 2 2 2 Bacterial protein of unknown function (DUF853) TrwB_AAD_bind PF10412.9 EPA06162.1 - 0.023 13.6 0.2 0.068 12.1 0.0 1.9 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain HAS-barrel PF09378.10 EPA06162.1 - 0.034 14.3 0.0 0.1 12.7 0.0 1.9 1 0 0 1 1 1 0 HAS barrel domain DUF4709 PF15821.5 EPA06162.1 - 0.04 14.2 1.1 0.11 12.8 1.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4709) AAA_16 PF13191.6 EPA06162.1 - 0.082 13.3 0.0 0.33 11.3 0.0 2.0 1 1 1 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 EPA06162.1 - 0.083 13.4 1.6 0.18 12.3 1.6 1.6 1 1 0 1 1 1 0 ABC transporter Metallophos_2 PF12850.7 EPA06163.1 - 4.6e-09 36.7 0.2 7e-09 36.1 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EPA06163.1 - 8.4e-08 32.9 3.8 1.5e-07 32.1 3.8 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CENP-C_C PF11699.8 EPA06163.1 - 0.011 15.9 0.0 0.024 14.9 0.0 1.5 1 0 0 1 1 1 0 Mif2/CENP-C like RST PF12174.8 EPA06163.1 - 0.072 13.0 0.1 0.25 11.3 0.1 1.9 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain DUF211 PF02680.14 EPA06163.1 - 0.19 11.9 3.1 18 5.5 1.3 3.5 2 1 1 3 3 3 0 Uncharacterized ArCR, COG1888 AAA_16 PF13191.6 EPA06164.1 - 0.093 13.1 0.0 0.98 9.8 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain N6_N4_Mtase PF01555.18 EPA06167.1 - 3.5e-45 154.5 0.0 6.1e-45 153.7 0.0 1.4 1 0 0 1 1 1 1 DNA methylase UPF0020 PF01170.18 EPA06167.1 - 1.3e-07 31.6 0.2 0.012 15.3 0.3 2.9 2 1 0 2 2 2 2 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 EPA06167.1 - 7.8e-07 29.0 0.0 2.3e-05 24.2 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA06167.1 - 1.3e-05 25.8 0.0 0.051 14.2 0.0 3.2 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_25 PF13649.6 EPA06167.1 - 4.7e-05 24.0 0.0 0.00055 20.6 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.10 EPA06167.1 - 0.058 13.0 0.0 1.3 8.5 0.0 2.3 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase Methyltransf_23 PF13489.6 EPA06167.1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EPA06167.1 - 0.13 13.0 0.0 5 7.9 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain Adenine_glyco PF03352.13 EPA06168.1 - 2.1e-73 245.9 0.5 2.8e-73 245.4 0.5 1.1 1 0 0 1 1 1 1 Methyladenine glycosylase DUF5615 PF18480.1 EPA06169.1 - 8.4e-06 25.4 0.0 2.2e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF5615) PIN_10 PF18478.1 EPA06169.1 - 0.00051 20.2 0.0 0.00068 19.8 0.0 1.2 1 0 0 1 1 1 1 PIN like domain Mut7-C PF01927.16 EPA06169.1 - 0.0062 16.6 0.0 0.0069 16.5 0.0 1.1 1 0 0 1 1 1 1 Mut7-C RNAse domain Phage_integrase PF00589.22 EPA06170.1 - 2.6e-07 30.6 0.1 1.3e-06 28.3 0.0 2.2 2 0 0 2 2 2 1 Phage integrase family Phage_int_SAM_4 PF13495.6 EPA06170.1 - 0.0016 18.9 2.5 0.14 12.6 1.5 3.6 2 1 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Tup_N PF08581.10 EPA06170.1 - 1.2 9.5 6.1 1.1 9.6 1.4 2.8 2 0 0 2 2 2 0 Tup N-terminal EVE PF01878.18 EPA06172.1 - 1.2e-08 35.1 0.2 1.5e-08 34.8 0.2 1.1 1 0 0 1 1 1 1 EVE domain Peptidase_S78_2 PF14550.6 EPA06172.1 - 0.09 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Putative phage serine protease XkdF PrlF_antitoxin PF15937.5 EPA06173.1 - 1.5e-06 28.5 0.1 1.7e-06 28.3 0.1 1.0 1 0 0 1 1 1 1 prlF antitoxin for toxin YhaV_toxin MazE_antitoxin PF04014.18 EPA06173.1 - 2.6e-06 27.2 0.1 2.7e-06 27.2 0.1 1.1 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin Thump_like PF18096.1 EPA06173.1 - 0.00072 19.4 0.1 0.00078 19.3 0.1 1.1 1 0 0 1 1 1 1 THUMP domain-like eIF-1a PF01176.19 EPA06173.1 - 0.058 13.2 0.1 0.089 12.6 0.1 1.4 1 1 0 1 1 1 0 Translation initiation factor 1A / IF-1 RHH_5 PF07878.11 EPA06173.1 - 0.063 13.2 0.2 0.14 12.1 0.1 1.7 2 0 0 2 2 2 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 PD40 PF07676.12 EPA06173.1 - 0.16 11.9 0.1 4.5 7.3 0.0 2.1 1 1 1 2 2 2 0 WD40-like Beta Propeller Repeat HTH_24 PF13412.6 EPA06174.1 - 0.0023 17.4 0.1 0.0055 16.2 0.1 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 EPA06174.1 - 0.0034 17.3 0.5 0.021 14.7 0.2 2.3 2 0 0 2 2 2 1 MarR family EAP30 PF04157.16 EPA06174.1 - 0.0091 15.3 0.0 0.026 13.8 0.0 1.8 1 1 0 1 1 1 1 EAP30/Vps36 family MarR_2 PF12802.7 EPA06174.1 - 0.0098 15.8 0.0 0.2 11.6 0.0 2.2 2 0 0 2 2 2 1 MarR family TrmB PF01978.19 EPA06174.1 - 0.06 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB RPA_C PF08784.11 EPA06174.1 - 0.085 13.5 0.3 0.22 12.2 0.3 1.7 1 0 0 1 1 1 0 Replication protein A C terminal Rio2_N PF09202.11 EPA06174.1 - 0.15 12.3 0.0 0.46 10.8 0.0 1.8 1 0 0 1 1 1 0 Rio2, N-terminal HATPase_c_3 PF13589.6 EPA06176.1 - 1.5e-07 31.3 0.3 3.2e-07 30.3 0.3 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EPA06176.1 - 0.00016 22.1 0.3 0.00016 22.1 0.3 2.1 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_S8 PF00410.19 EPA06176.1 - 0.071 13.1 0.1 0.41 10.6 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein S8 ThaI PF15514.6 EPA06176.1 - 0.075 12.7 1.8 0.28 10.8 0.6 2.3 2 0 0 2 2 2 0 Restriction endonuclease ThaI MciZ PF13072.6 EPA06177.1 - 0.28 11.0 0.1 0.28 11.0 0.1 2.2 3 0 0 3 3 3 0 Mother cell inhibitor of FtsZ DUF1837 PF08878.11 EPA06178.1 - 1.5e-10 41.3 6.5 1.8e-10 41.0 6.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF1837) CREPT PF16566.5 EPA06179.1 - 0.0066 16.6 1.6 0.013 15.7 0.1 1.9 2 0 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour HeLo PF14479.6 EPA06179.1 - 0.033 14.0 1.3 0.16 11.8 0.1 2.2 2 0 0 2 2 2 0 Prion-inhibition and propagation CdvA PF18822.1 EPA06179.1 - 0.067 13.0 5.8 0.091 12.6 0.9 2.8 2 2 1 3 3 3 0 CdvA-like coiled-coil domain Ribosomal_L13e PF01294.18 EPA06180.1 - 0.016 15.1 0.1 0.016 15.1 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein L13e DUF4351 PF14261.6 EPA06180.1 - 0.043 13.9 0.4 0.13 12.4 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4351) SH3_1 PF00018.28 EPA06181.1 - 0.16 11.6 0.1 0.21 11.2 0.1 1.2 1 0 0 1 1 1 0 SH3 domain DNA_methylase PF00145.17 EPA06184.1 - 2.4e-55 188.2 0.1 4.7e-55 187.3 0.1 1.4 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase HhH-GPD PF00730.25 EPA06185.1 - 2.2e-14 53.8 0.0 3.8e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EPA06185.1 - 1.7e-10 40.2 0.0 3.5e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 EPA06185.1 - 1.3e-06 28.5 6.1 2.3e-06 27.8 6.1 1.4 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III HRDC PF00570.23 EPA06185.1 - 0.053 13.5 0.0 1.1 9.3 0.0 2.8 2 0 0 2 2 2 0 HRDC domain DUF763 PF05559.11 EPA06185.1 - 0.12 11.5 0.0 0.23 10.6 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF763) HHH_5 PF14520.6 EPA06185.1 - 0.14 12.8 0.0 0.51 11.0 0.0 2.0 2 0 0 2 2 2 0 Helix-hairpin-helix domain WSN PF02206.18 EPA06185.1 - 0.41 10.6 2.9 0.59 10.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function DEAD PF00270.29 EPA06187.1 - 4.3e-24 85.2 0.0 1.1e-23 83.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EPA06187.1 - 1.7e-11 44.4 0.1 5.3e-10 39.6 0.1 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EPA06187.1 - 1.9e-11 44.3 0.0 6.7e-11 42.5 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HIRAN PF08797.11 EPA06187.1 - 2.2e-10 40.3 0.0 5.3e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain Lactamase_B_2 PF12706.7 EPA06188.1 - 1.5e-12 47.5 1.3 2.6e-12 46.7 0.1 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EPA06188.1 - 7.8e-07 29.3 0.4 0.00093 19.3 0.2 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily RMMBL PF07521.12 EPA06188.1 - 0.00014 21.7 0.5 0.0039 17.1 0.0 2.5 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_3 PF13483.6 EPA06188.1 - 0.00016 21.6 0.0 0.00052 19.9 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain SIS PF01380.22 EPA06188.1 - 0.032 14.1 0.0 4.5 7.1 0.0 2.3 2 0 0 2 2 2 0 SIS domain Ephrin_lbd PF01404.19 EPA06189.1 - 0.049 13.7 0.1 0.083 12.9 0.1 1.3 1 0 0 1 1 1 0 Ephrin receptor ligand binding domain Ribonuc_red_lgC PF02867.15 EPA06190.1 - 3.6e-183 609.9 0.0 8.5e-183 608.6 0.0 1.6 2 0 0 2 2 2 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EPA06190.1 - 2.4e-31 107.6 0.0 5.1e-31 106.5 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EPA06190.1 - 2.1e-21 76.3 1.7 5.6e-21 74.9 0.9 2.2 2 0 0 2 2 2 1 ATP cone domain HEPN_RES_NTD1 PF18870.1 EPA06190.1 - 0.13 12.5 0.3 9.8 6.4 0.0 3.4 3 0 0 3 3 3 0 HEPN/RES N-terminal domain 1 Peptidase_S8 PF00082.22 EPA06193.1 - 1e-21 77.5 7.2 5.5e-14 52.1 0.4 3.0 2 1 0 2 2 2 2 Subtilase family Peripla_BP_4 PF13407.6 EPA06193.1 - 0.0093 15.6 2.7 1.9 8.0 0.0 2.9 3 0 0 3 3 3 2 Periplasmic binding protein domain PrlF_antitoxin PF15937.5 EPA06193.1 - 0.41 11.1 2.7 0.33 11.4 0.3 2.1 2 0 0 2 2 2 0 prlF antitoxin for toxin YhaV_toxin CENP-H PF05837.12 EPA06193.1 - 0.83 10.1 7.7 0.1 13.0 2.7 2.0 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DZR PF12773.7 EPA06194.1 - 0.024 14.6 0.9 0.031 14.3 0.9 1.1 1 0 0 1 1 1 0 Double zinc ribbon PolC_DP2 PF03833.13 EPA06194.1 - 0.032 12.1 0.0 0.032 12.1 0.0 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-C3HC4_3 PF13920.6 EPA06194.1 - 0.06 13.2 1.1 0.083 12.8 1.1 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HypA PF01155.19 EPA06194.1 - 0.062 13.3 0.1 0.064 13.3 0.1 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FHIPEP PF00771.20 EPA06194.1 - 0.092 11.2 0.0 0.092 11.2 0.0 1.0 1 0 0 1 1 1 0 FHIPEP family TF_Zn_Ribbon PF08271.12 EPA06194.1 - 0.87 9.2 6.8 4.4 6.9 0.4 2.2 1 1 1 2 2 2 0 TFIIB zinc-binding Spc7 PF08317.11 EPA06195.1 - 0.0037 16.2 21.4 0.0037 16.2 21.4 3.0 1 1 2 3 3 3 2 Spc7 kinetochore protein TMPIT PF07851.13 EPA06195.1 - 0.21 10.8 28.4 1.1 8.4 4.0 2.2 2 0 0 2 2 2 0 TMPIT-like protein MAD PF05557.13 EPA06195.1 - 0.58 8.5 41.6 0.17 10.2 27.9 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF745 PF05335.13 EPA06195.1 - 2.6 7.7 31.9 0.44 10.2 7.7 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF745) DUF4404 PF14357.6 EPA06195.1 - 8 7.2 26.8 1.3 9.7 3.1 4.1 1 1 3 4 4 4 0 Domain of unknown function (DUF4404) PAP2 PF01569.21 EPA06196.1 - 7.3e-17 61.4 0.9 8.4e-17 61.2 0.9 1.0 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EPA06196.1 - 9.5e-10 38.5 1.7 1.1e-09 38.2 1.7 1.1 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 EPA06196.1 - 4.9e-06 27.0 0.1 6.4e-06 26.6 0.1 1.1 1 0 0 1 1 1 1 PAP2 superfamily C-terminal DUF212 PF02681.14 EPA06196.1 - 0.034 14.3 0.6 0.33 11.1 0.6 2.0 1 1 0 1 1 1 0 Divergent PAP2 family Ribosomal_S28e PF01200.18 EPA06198.1 - 2.8e-27 94.5 4.4 3e-27 94.4 4.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e tRNA-synt_His PF13393.6 EPA06199.1 - 1.9e-26 93.1 0.0 2.1e-26 93.0 0.0 1.0 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 EPA06199.1 - 2.9e-12 46.9 0.1 4.3e-12 46.4 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.20 EPA06199.1 - 0.00045 19.8 0.0 0.00056 19.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) YHS PF04945.13 EPA06200.1 - 3e-17 62.5 1.2 3.2e-17 62.4 1.2 1.0 1 0 0 1 1 1 1 YHS domain Arc_trans_TRASH PF08394.10 EPA06200.1 - 0.00065 20.0 0.7 0.00082 19.7 0.7 1.2 1 0 0 1 1 1 1 Archaeal TRASH domain zf-FCS PF06467.14 EPA06200.1 - 0.012 15.5 1.1 0.014 15.3 1.1 1.1 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif FAP206 PF12018.8 EPA06200.1 - 0.034 13.7 0.1 0.038 13.5 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function Radical_SAM PF04055.21 EPA06201.1 - 3.9e-15 56.6 0.1 8.3e-15 55.6 0.0 1.6 2 0 0 2 2 2 1 Radical SAM superfamily zinc_ribbon_2 PF13240.6 EPA06203.1 - 1.8e-08 33.8 4.4 3.4e-08 32.9 4.4 1.4 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.6 EPA06203.1 - 1.9e-06 27.0 2.1 3.1e-06 26.4 2.1 1.3 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 EPA06203.1 - 5.5e-06 26.3 1.6 9.7e-06 25.5 1.6 1.4 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_15 PF17032.5 EPA06203.1 - 8.3e-05 23.3 0.2 0.00011 22.9 0.2 1.2 1 0 0 1 1 1 1 zinc-ribbon family UPF0547 PF10571.9 EPA06203.1 - 0.00021 21.3 4.0 0.00052 20.0 3.9 1.7 1 1 0 1 1 1 1 Uncharacterised protein family UPF0547 Nudix_N_2 PF14803.6 EPA06203.1 - 0.0056 16.6 8.8 0.11 12.4 0.3 2.6 3 0 0 3 3 2 2 Nudix N-terminal RNA_POL_M_15KD PF02150.16 EPA06203.1 - 0.035 14.0 3.6 2.9 7.9 0.5 2.4 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit A2L_zn_ribbon PF08792.10 EPA06203.1 - 0.041 13.6 1.7 2.1 8.2 0.2 2.3 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-NADH-PPase PF09297.11 EPA06203.1 - 0.062 13.0 5.6 20 4.9 5.6 2.2 1 1 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain HypA PF01155.19 EPA06203.1 - 0.065 13.2 0.7 0.091 12.8 0.7 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Prok-RING_1 PF14446.6 EPA06203.1 - 0.082 12.8 2.0 0.13 12.2 2.0 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 NRDD PF13597.6 EPA06203.1 - 0.085 11.6 0.4 0.1 11.4 0.4 1.1 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase zf_UBZ PF18439.1 EPA06203.1 - 0.13 11.9 3.7 1.5 8.5 0.1 2.3 1 1 1 2 2 2 0 Ubiquitin-Binding Zinc Finger ADK_lid PF05191.14 EPA06203.1 - 0.34 10.9 2.9 12 6.0 2.9 2.2 1 1 0 1 1 1 0 Adenylate kinase, active site lid NOB1_Zn_bind PF08772.11 EPA06203.1 - 0.36 11.0 6.5 3.8 7.8 6.8 2.2 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like GFA PF04828.14 EPA06203.1 - 0.58 10.5 4.0 25 5.3 4.0 2.3 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme RecR PF02132.15 EPA06203.1 - 0.75 9.4 2.9 20 4.8 2.9 2.1 1 1 0 1 1 1 0 RecR protein YhfH PF14149.6 EPA06203.1 - 0.77 9.8 4.9 11 6.0 0.3 2.3 1 1 1 2 2 2 0 YhfH-like protein zf-tcix PF14952.6 EPA06203.1 - 1.2 8.8 5.9 3.9 7.2 0.8 2.2 1 1 1 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding LisH_2 PF16045.5 EPA06203.1 - 3.4 6.8 8.1 5.3 6.2 0.7 2.9 3 0 0 3 3 3 0 LisH DZR PF12773.7 EPA06204.1 - 2.7e-06 27.3 9.5 0.00031 20.7 3.3 2.5 2 1 0 2 2 2 2 Double zinc ribbon PRC PF05239.16 EPA06204.1 - 5.5e-06 26.4 0.5 1e-05 25.5 0.5 1.4 1 0 0 1 1 1 1 PRC-barrel domain zinc_ribbon_2 PF13240.6 EPA06204.1 - 1.6e-05 24.4 7.0 1.6e-05 24.4 7.0 2.3 3 0 0 3 3 3 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 EPA06204.1 - 5.7e-05 23.8 3.6 0.058 14.2 0.2 2.3 2 0 0 2 2 2 2 zinc-ribbon family GFA PF04828.14 EPA06204.1 - 0.00018 21.8 1.0 6 7.3 0.0 3.4 3 0 0 3 3 3 1 Glutathione-dependent formaldehyde-activating enzyme zf-B_box PF00643.24 EPA06204.1 - 0.043 14.0 10.7 2.1 8.6 0.8 3.2 3 0 0 3 3 3 0 B-box zinc finger zinc-ribbons_6 PF07191.12 EPA06204.1 - 0.094 12.7 12.0 0.99 9.4 1.8 3.1 2 1 1 3 3 3 0 zinc-ribbons Prim_Zn_Ribbon PF08273.12 EPA06204.1 - 0.12 12.7 9.4 11 6.3 0.0 3.8 3 1 0 3 3 3 0 Zinc-binding domain of primase-helicase A2L_zn_ribbon PF08792.10 EPA06204.1 - 0.39 10.5 0.1 0.39 10.5 0.1 4.3 3 1 0 3 3 3 0 A2L zinc ribbon domain HypA PF01155.19 EPA06204.1 - 0.54 10.3 7.4 3 7.9 0.5 2.5 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DNA_RNApol_7kD PF03604.13 EPA06204.1 - 1.3 8.8 10.2 3.5 7.4 0.1 4.1 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit zf-AD PF07776.15 EPA06204.1 - 1.4 9.2 5.9 1.9 8.8 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) PHD PF00628.29 EPA06204.1 - 1.7 8.6 8.8 14 5.6 0.1 3.3 3 0 0 3 3 3 0 PHD-finger zf-CHY PF05495.12 EPA06204.1 - 2.3 8.8 10.2 5.2 7.6 2.1 2.6 2 1 0 2 2 2 0 CHY zinc finger Tnp_zf-ribbon_2 PF13842.6 EPA06204.1 - 2.8 8.8 0.0 2.8 8.8 0.0 3.4 3 1 0 3 3 3 0 DDE_Tnp_1-like zinc-ribbon zf_UBZ PF18439.1 EPA06204.1 - 3.9 7.2 12.9 19 5.0 0.2 4.1 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger DUF2197 PF09963.9 EPA06204.1 - 5.4 7.3 7.8 15 5.9 0.2 2.8 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2197) Thioredoxin PF00085.20 EPA06205.1 - 5.3e-29 100.2 0.1 7.6e-29 99.7 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EPA06205.1 - 4.2e-07 30.4 0.1 1.5e-06 28.6 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 EPA06205.1 - 4.7e-07 29.6 0.4 7.4e-07 29.0 0.4 1.4 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EPA06205.1 - 1.3e-06 28.6 0.2 5.8e-06 26.5 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 EPA06205.1 - 4.4e-06 26.3 0.7 8.4e-06 25.3 0.7 1.5 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Phosducin PF02114.16 EPA06205.1 - 6e-05 22.1 0.0 6.6e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Phosducin Redoxin PF08534.10 EPA06205.1 - 0.00096 18.9 0.0 0.0012 18.6 0.0 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.6 EPA06205.1 - 0.0014 18.7 0.1 0.0025 17.9 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like HyaE PF07449.11 EPA06205.1 - 0.007 16.3 0.0 0.2 11.7 0.0 2.0 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE TraF PF13728.6 EPA06205.1 - 0.0071 16.2 0.1 0.0094 15.8 0.1 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein AhpC-TSA PF00578.21 EPA06205.1 - 0.008 16.1 0.0 0.01 15.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Glutaredoxin PF00462.24 EPA06205.1 - 0.079 13.2 0.1 0.2 11.9 0.0 1.7 2 0 0 2 2 2 0 Glutaredoxin TF_Zn_Ribbon PF08271.12 EPA06206.1 - 0.006 16.1 0.9 1.8 8.1 0.1 2.2 2 0 0 2 2 2 2 TFIIB zinc-binding zf-C3HC4_5 PF17121.5 EPA06206.1 - 0.012 15.5 0.2 0.022 14.6 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C2HC5 PF06221.13 EPA06206.1 - 0.027 14.5 0.2 0.03 14.3 0.2 1.1 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type RecR PF02132.15 EPA06206.1 - 0.033 13.8 2.6 0.06 12.9 2.6 1.5 1 1 0 1 1 1 0 RecR protein zf-C2H2 PF00096.26 EPA06206.1 - 0.092 13.2 0.7 2 9.0 0.0 2.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EPA06206.1 - 0.099 13.5 0.7 20 6.3 0.0 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_3 PF13878.6 EPA06206.1 - 0.11 12.4 1.1 0.39 10.6 0.0 2.0 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO LSM PF01423.22 EPA06208.1 - 1.2e-23 82.5 0.6 1.4e-23 82.4 0.6 1.0 1 0 0 1 1 1 1 LSM domain Cupredoxin_1 PF13473.6 EPA06209.1 - 3.7e-08 33.4 0.0 5.4e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Cupredoxin-like domain NicO PF03824.16 EPA06211.1 - 4e-06 26.4 16.2 5.9e-06 25.8 16.2 1.2 1 0 0 1 1 1 1 High-affinity nickel-transport protein Archease PF01951.16 EPA06212.1 - 3.4e-30 105.1 1.4 3.7e-30 105.0 1.4 1.0 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) YbjQ_1 PF01906.17 EPA06212.1 - 0.03 15.0 0.0 0.049 14.3 0.0 1.3 1 0 0 1 1 1 0 Putative heavy-metal-binding RdgC PF04381.12 EPA06212.1 - 0.035 13.4 0.3 0.043 13.1 0.3 1.1 1 0 0 1 1 1 0 Putative exonuclease, RdgC Ribosomal_L7Ae PF01248.26 EPA06213.1 - 7.2e-26 89.8 0.1 8.8e-26 89.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EPA06213.1 - 0.0013 18.6 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain Creatininase PF02633.14 EPA06214.1 - 9.8e-50 169.3 0.0 1.3e-49 168.8 0.0 1.0 1 0 0 1 1 1 1 Creatinine amidohydrolase HflK_N PF12221.8 EPA06214.1 - 0.17 11.9 0.1 0.65 10.1 0.0 2.0 2 0 0 2 2 2 0 Bacterial membrane protein N terminal Peptidase_S24 PF00717.23 EPA06216.1 - 3.2e-07 30.2 0.5 3.2e-07 30.2 0.5 2.3 2 0 0 2 2 2 1 Peptidase S24-like MscL PF01741.18 EPA06216.1 - 0.054 13.8 2.3 0.1 12.9 0.0 2.2 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL TrbC PF04956.13 EPA06216.1 - 1.2 9.4 5.2 4.8 7.5 1.1 2.2 2 0 0 2 2 2 0 TrbC/VIRB2 family Vpu PF00558.19 EPA06216.1 - 1.3 8.8 8.0 0.29 10.9 0.5 2.4 2 0 0 2 2 2 0 Vpu protein Amidohydro_1 PF01979.20 EPA06217.1 - 3.9e-21 75.7 0.3 1.4e-20 74.0 0.3 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EPA06217.1 - 2.5e-14 53.6 0.1 1.3e-08 34.7 0.0 3.3 2 1 1 3 3 3 3 Amidohydrolase family TatD_DNase PF01026.21 EPA06217.1 - 0.00068 19.1 0.1 0.0013 18.2 0.0 1.6 2 1 0 2 2 2 1 TatD related DNase Hom_end PF05204.14 EPA06217.1 - 0.16 12.1 0.0 3.2 8.0 0.0 2.4 2 0 0 2 2 2 0 Homing endonuclease DsbD PF02683.15 EPA06218.1 - 1.6e-15 57.6 16.9 1.6e-15 57.6 16.9 1.5 2 0 0 2 2 2 1 Cytochrome C biogenesis protein transmembrane region DsbD_2 PF13386.6 EPA06218.1 - 4.7e-05 23.4 25.7 5.5e-05 23.2 8.6 2.7 2 1 1 3 3 3 2 Cytochrome C biogenesis protein transmembrane region Formyl_trans_N PF00551.19 EPA06219.1 - 8.1e-45 152.8 0.1 1.1e-44 152.3 0.1 1.2 1 0 0 1 1 1 1 Formyl transferase ACT_6 PF13740.6 EPA06219.1 - 9.8e-07 28.7 0.0 2.2e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 ACT domain ACT PF01842.25 EPA06219.1 - 0.005 16.6 0.2 0.029 14.2 0.1 2.4 2 1 0 2 2 2 1 ACT domain ACT_4 PF13291.6 EPA06219.1 - 0.025 15.2 0.2 0.093 13.3 0.1 2.1 1 1 1 2 2 2 0 ACT domain HpaB_N PF11794.8 EPA06221.1 - 2.6e-95 319.2 0.0 4.4e-95 318.5 0.0 1.3 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal HpaB PF03241.13 EPA06221.1 - 3.2e-71 238.6 0.3 4.4e-71 238.1 0.3 1.2 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase C terminal Acyl-CoA_dh_M PF02770.19 EPA06221.1 - 0.092 13.0 0.0 0.42 10.8 0.0 2.1 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, middle domain Bt_P21 PF05560.11 EPA06221.1 - 0.094 12.3 0.2 15 5.1 0.0 2.3 2 0 0 2 2 2 0 Bacillus thuringiensis P21 molecular chaperone protein Thioredoxin PF00085.20 EPA06222.1 - 7.2e-31 106.2 0.1 8.2e-31 106.1 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EPA06222.1 - 3.7e-11 43.2 0.2 1.1e-06 28.8 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EPA06222.1 - 2e-08 34.6 0.1 8.1e-08 32.7 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EPA06222.1 - 3.2e-06 27.2 0.1 5.1e-06 26.6 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_3 PF13192.6 EPA06222.1 - 4e-06 26.8 0.1 4.6e-06 26.6 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_9 PF14595.6 EPA06222.1 - 4.8e-06 26.4 0.1 5.7e-06 26.1 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 EPA06222.1 - 5.3e-05 23.1 0.0 6.1e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family TraF PF13728.6 EPA06222.1 - 0.00021 21.2 0.0 0.00025 21.0 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein OST3_OST6 PF04756.13 EPA06222.1 - 0.00034 20.1 0.0 0.00034 20.1 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Redoxin PF08534.10 EPA06222.1 - 0.00036 20.2 0.2 0.00075 19.2 0.2 1.5 1 1 0 1 1 1 1 Redoxin HyaE PF07449.11 EPA06222.1 - 0.001 19.0 0.0 0.0013 18.7 0.0 1.2 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE DUF953 PF06110.11 EPA06222.1 - 0.004 16.8 0.2 0.01 15.4 0.2 1.8 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_6 PF13848.6 EPA06222.1 - 0.0061 16.5 0.0 0.018 14.9 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_4 PF13462.6 EPA06222.1 - 0.01 16.0 0.1 0.64 10.2 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin Glutaredoxin PF00462.24 EPA06222.1 - 0.029 14.6 0.0 0.05 13.8 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin DSBA PF01323.20 EPA06222.1 - 0.092 12.5 0.1 1.1 9.0 0.0 2.0 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DUF836 PF05768.14 EPA06222.1 - 0.13 12.7 0.0 0.18 12.3 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) zinc_ribbon_2 PF13240.6 EPA06223.1 - 6.7e-07 28.8 4.9 9.9e-07 28.3 4.9 1.3 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 EPA06223.1 - 9.5e-05 22.3 1.4 0.00014 21.9 1.4 1.2 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_15 PF17032.5 EPA06223.1 - 0.00072 20.3 0.2 0.0017 19.0 0.2 1.6 2 0 0 2 2 2 1 zinc-ribbon family zf-ribbon_3 PF13248.6 EPA06223.1 - 0.003 16.9 4.0 0.005 16.2 4.0 1.4 1 0 0 1 1 1 1 zinc-ribbon domain UPF0547 PF10571.9 EPA06223.1 - 0.078 13.1 1.4 0.12 12.5 1.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 YkyA PF10368.9 EPA06223.1 - 0.16 11.7 0.7 0.2 11.3 0.7 1.1 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein DUF35_N PF12172.8 EPA06223.1 - 0.19 11.7 2.1 0.31 11.0 2.1 1.3 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Nudix_N_2 PF14803.6 EPA06223.1 - 2.5 8.1 7.1 2.1 8.3 1.4 2.2 2 0 0 2 2 2 0 Nudix N-terminal Thioredoxin_3 PF13192.6 EPA06224.1 - 1.8e-10 40.7 0.0 1.9e-10 40.7 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin domain Glutaredoxin PF00462.24 EPA06224.1 - 0.00092 19.4 0.0 0.0013 18.9 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin KaiB PF07689.12 EPA06224.1 - 0.0026 17.5 0.0 0.0034 17.1 0.0 1.1 1 0 0 1 1 1 1 KaiB domain HTH_5 PF01022.20 EPA06225.1 - 1.2e-09 37.9 0.5 4.3e-09 36.1 0.1 1.8 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 EPA06225.1 - 2.8e-05 24.1 0.0 7.4e-05 22.7 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_24 PF13412.6 EPA06225.1 - 7.7e-05 22.2 0.4 0.00015 21.3 0.4 1.5 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 EPA06225.1 - 0.00011 22.1 0.1 0.00024 20.9 0.0 1.5 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 EPA06225.1 - 0.00058 19.7 0.2 0.001 18.9 0.2 1.4 1 0 0 1 1 1 1 HTH domain HTH_45 PF14947.6 EPA06225.1 - 0.0013 18.7 2.3 0.0019 18.1 2.3 1.4 1 1 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 EPA06225.1 - 0.0021 18.0 0.2 0.004 17.0 0.2 1.5 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 EPA06225.1 - 0.0072 16.2 0.0 0.016 15.1 0.0 1.6 1 1 1 2 2 2 1 MarR family B-block_TFIIIC PF04182.12 EPA06225.1 - 0.01 16.0 0.1 0.015 15.5 0.1 1.3 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC MSV199 PF10553.9 EPA06225.1 - 0.014 15.7 1.8 0.016 15.4 1.8 1.1 1 0 0 1 1 1 0 MSV199 domain HTH_29 PF13551.6 EPA06225.1 - 0.023 14.7 0.0 0.034 14.2 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix Phage_rep_O PF04492.13 EPA06225.1 - 0.025 15.1 0.1 0.035 14.7 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage replication protein O DUF4423 PF14394.6 EPA06225.1 - 0.03 14.0 0.9 0.13 12.0 0.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4423) DprA_WH PF17782.1 EPA06225.1 - 0.035 14.2 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 DprA winged helix domain HTH_12 PF08461.10 EPA06225.1 - 0.053 13.5 0.1 0.093 12.7 0.1 1.4 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain HTH_1 PF00126.27 EPA06225.1 - 0.063 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family DUF3781 PF12636.7 EPA06225.1 - 0.073 13.0 1.4 0.09 12.7 1.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3781) HTH_41 PF14502.6 EPA06225.1 - 0.096 12.4 0.1 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_10 PF04967.12 EPA06225.1 - 0.11 12.4 0.1 0.32 10.8 0.0 1.7 2 0 0 2 2 2 0 HTH DNA binding domain Rib_5-P_isom_A PF06026.14 EPA06226.1 - 1.2e-53 181.2 0.1 1.4e-53 181.0 0.1 1.0 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 EPA06226.1 - 0.0046 16.9 0.1 0.23 11.4 0.0 2.2 2 0 0 2 2 2 2 DeoR C terminal sensor domain Ribosomal_L24e PF01246.20 EPA06227.1 - 1.3e-18 67.0 1.0 1.3e-18 67.0 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L24e zf-FLZ PF04570.14 EPA06227.1 - 0.014 14.9 0.2 0.023 14.2 0.2 1.4 1 1 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 DUF2256 PF10013.9 EPA06227.1 - 0.065 13.4 6.0 5.6 7.2 0.1 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) RVT_3 PF13456.6 EPA06228.1 - 7.3e-12 45.2 0.0 8.6e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase-like RNase_H PF00075.24 EPA06228.1 - 2.2e-11 44.1 0.0 2.5e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 RNase H Dynactin_p22 PF07426.11 EPA06228.1 - 0.06 13.2 0.1 0.075 12.9 0.1 1.1 1 0 0 1 1 1 0 Dynactin subunit p22 YflT PF11181.8 EPA06228.1 - 0.1 13.1 0.1 0.12 12.9 0.1 1.1 1 0 0 1 1 1 0 Heat induced stress protein YflT MTS_N PF08468.11 EPA06229.1 - 0.006 16.7 0.1 0.012 15.6 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain N-terminal Flagellin_C PF00700.21 EPA06229.1 - 0.034 14.5 0.3 0.33 11.3 0.2 2.6 1 1 1 2 2 2 0 Bacterial flagellin C-terminal helical region PGM_PMM_I PF02878.16 EPA06230.1 - 1.9e-36 124.8 0.0 3.4e-36 124.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EPA06230.1 - 5.9e-25 87.9 0.0 1.2e-24 86.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EPA06230.1 - 2.6e-23 82.4 0.0 4.5e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EPA06230.1 - 1.5e-08 34.7 0.0 3.4e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain ATP-grasp_5 PF13549.6 EPA06231.1 - 1.7e-79 266.4 1.0 3e-79 265.6 1.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 EPA06231.1 - 5e-52 175.4 2.3 5.3e-52 175.3 0.8 1.9 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EPA06231.1 - 5e-21 75.4 0.7 1.8e-20 73.5 0.1 2.2 2 1 1 3 3 3 1 CoA binding domain CoA_binding PF02629.19 EPA06231.1 - 2.7e-07 31.2 1.0 2.7e-07 31.2 1.0 2.5 2 0 0 2 2 2 1 CoA binding domain ATP-grasp_2 PF08442.10 EPA06231.1 - 5.8e-05 22.7 2.0 0.00012 21.7 2.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Dak1_2 PF13684.6 EPA06231.1 - 0.0032 16.6 0.3 0.0086 15.2 0.3 1.7 1 1 0 1 1 1 1 Dihydroxyacetone kinase family CPSase_L_D2 PF02786.17 EPA06231.1 - 0.0055 16.2 0.2 0.01 15.3 0.2 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.22 EPA06231.1 - 0.11 12.0 0.2 0.41 10.2 0.2 1.9 1 1 0 1 1 1 0 ATP-grasp domain HTH_AsnC-type PF13404.6 EPA06233.1 - 6.4e-13 48.3 0.1 9.4e-13 47.8 0.1 1.3 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 EPA06233.1 - 8.1e-11 41.3 0.1 1.3e-10 40.7 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Arc_trans_TRASH PF08394.10 EPA06233.1 - 2.1e-05 24.7 4.3 3.9e-05 23.9 4.3 1.5 1 0 0 1 1 1 1 Archaeal TRASH domain TrmB PF01978.19 EPA06233.1 - 8.9e-05 22.3 0.0 0.00017 21.4 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_Tnp_ISL3 PF13542.6 EPA06233.1 - 0.00041 19.7 0.0 0.00061 19.1 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_5 PF01022.20 EPA06233.1 - 0.00079 19.2 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family DUF2250 PF10007.9 EPA06233.1 - 0.0043 17.1 1.5 0.28 11.3 1.5 2.2 1 1 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2250) HTH_9 PF08221.11 EPA06233.1 - 0.0058 16.7 0.0 0.0096 16.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_38 PF13936.6 EPA06233.1 - 0.0059 16.3 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 EPA06233.1 - 0.012 15.4 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 MarR family HTH_23 PF13384.6 EPA06233.1 - 0.022 14.5 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain zf-FCS PF06467.14 EPA06233.1 - 0.03 14.2 3.6 0.066 13.2 3.6 1.5 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif ATPase-cat_bd PF12156.8 EPA06233.1 - 0.049 14.4 0.7 0.049 14.4 0.7 1.8 3 0 0 3 3 1 0 Putative metal-binding domain of cation transport ATPase DUF4423 PF14394.6 EPA06233.1 - 0.051 13.3 0.0 0.084 12.6 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4423) Fe_dep_repress PF01325.19 EPA06233.1 - 0.087 13.0 0.2 0.24 11.6 0.0 1.7 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain Sigma70_r4_2 PF08281.12 EPA06233.1 - 0.088 12.5 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 NDK PF00334.19 EPA06234.1 - 1.3e-49 167.6 0.0 1.5e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase DsrH PF04077.12 EPA06234.1 - 0.17 12.0 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 DsrH like protein He_PIG PF05345.12 EPA06235.1 - 6.4e-09 35.9 0.3 2e-08 34.3 0.3 1.9 1 0 0 1 1 1 1 Putative Ig domain Occludin_ELL PF07303.13 EPA06235.1 - 0.042 14.6 1.4 13 6.6 0.1 2.5 2 0 0 2 2 2 0 Occludin homology domain Trypan_PARP PF05887.11 EPA06235.1 - 0.16 12.0 6.0 0.34 10.9 6.0 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) GTP_EFTU PF00009.27 EPA06236.1 - 2.9e-32 111.8 0.0 7.2e-32 110.5 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D4 PF14578.6 EPA06236.1 - 3.2e-22 78.2 0.2 1.2e-21 76.4 0.2 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 IF-2 PF11987.8 EPA06236.1 - 1e-21 77.0 0.6 3e-21 75.5 0.6 1.9 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EPA06236.1 - 6.9e-09 35.8 0.6 1.8e-07 31.2 0.0 2.8 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 EPA06236.1 - 3.3e-05 24.1 0.0 0.00011 22.4 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU_D2 PF03144.25 EPA06236.1 - 9.2e-05 22.8 0.7 0.00059 20.2 0.0 2.7 3 0 0 3 3 3 1 Elongation factor Tu domain 2 ATP_bind_1 PF03029.17 EPA06236.1 - 0.00011 22.0 0.0 0.00047 20.0 0.0 1.9 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EPA06236.1 - 0.00074 19.6 0.5 0.059 13.4 0.1 2.8 1 1 0 2 2 2 1 Dynamin family Ras PF00071.22 EPA06236.1 - 0.0018 17.9 0.1 0.033 13.8 0.0 2.7 2 1 0 2 2 2 1 Ras family cobW PF02492.19 EPA06236.1 - 0.0079 15.8 1.6 0.71 9.4 0.3 2.8 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.10 EPA06236.1 - 0.023 14.2 0.1 0.1 12.1 0.0 2.2 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EPA06236.1 - 0.11 12.3 0.3 1.6 8.4 0.0 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DUF4473 PF14747.6 EPA06236.1 - 0.18 12.4 0.6 17 6.0 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) DUF475 PF04332.15 EPA06237.1 - 0.0037 17.1 4.5 0.0045 16.8 4.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF475) E1-N PF14463.6 EPA06237.1 - 0.18 11.6 0.1 0.34 10.7 0.1 1.4 1 0 0 1 1 1 0 E1 N-terminal domain Ndc1_Nup PF09531.10 EPA06237.1 - 1 7.9 4.8 1.3 7.6 4.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3106 PF11304.8 EPA06238.1 - 0.00016 22.1 15.8 0.62 10.6 0.0 6.1 2 2 2 5 5 5 3 Protein of unknown function (DUF3106) FGAR-AT_N PF18076.1 EPA06238.1 - 0.63 10.1 8.6 6.7 6.7 0.1 3.8 2 2 1 3 3 3 0 Formylglycinamide ribonucleotide amidotransferase N-terminal Fibrillarin PF01269.17 EPA06239.1 - 1.7e-88 295.6 0.2 2e-88 295.3 0.2 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EPA06239.1 - 4.7e-05 23.2 0.0 6.8e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 EPA06239.1 - 0.0019 18.0 0.0 0.0032 17.2 0.0 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF4651 PF15513.6 EPA06239.1 - 0.019 14.8 0.0 0.047 13.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4651) FtsJ PF01728.19 EPA06240.1 - 1.1e-48 165.7 0.0 1.2e-48 165.5 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 EPA06240.1 - 6.6e-05 22.7 0.0 8.5e-05 22.4 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA06240.1 - 7.1e-05 23.4 0.1 0.00025 21.7 0.1 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 EPA06240.1 - 0.0043 16.7 0.0 0.0072 16.0 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 EPA06240.1 - 0.0083 15.9 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EPA06240.1 - 0.0095 15.8 0.0 0.015 15.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain RNA_pol_Rpc34 PF05158.12 EPA06241.1 - 0.00013 21.4 0.5 0.00023 20.6 0.3 1.6 1 1 0 1 1 1 1 RNA polymerase Rpc34 subunit MarR PF01047.22 EPA06241.1 - 0.018 15.0 0.1 0.035 14.0 0.1 1.4 1 0 0 1 1 1 0 MarR family PI3_PI4_kinase PF00454.27 EPA06241.1 - 0.041 13.7 0.1 0.065 13.0 0.1 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase DUF3194 PF11419.8 EPA06241.1 - 0.073 13.4 4.0 0.13 12.7 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3194) z-alpha PF02295.17 EPA06241.1 - 0.12 12.4 0.1 0.12 12.4 0.1 2.1 3 0 0 3 3 3 0 Adenosine deaminase z-alpha domain RPA_C PF08784.11 EPA06241.1 - 0.14 12.8 0.0 0.2 12.4 0.0 1.2 1 0 0 1 1 1 0 Replication protein A C terminal DUF4956 PF16316.5 EPA06241.1 - 0.31 10.7 0.6 0.45 10.2 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4956) RNase_HII PF01351.18 EPA06242.1 - 6.8e-45 153.4 0.2 7.7e-45 153.2 0.2 1.0 1 0 0 1 1 1 1 Ribonuclease HII TRM PF02005.16 EPA06243.1 - 2.6e-83 280.3 0.0 3e-83 280.1 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_31 PF13847.6 EPA06243.1 - 0.013 15.3 0.0 0.23 11.2 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Met_10 PF02475.16 EPA06243.1 - 0.014 15.2 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Rrf2 PF02082.20 EPA06243.1 - 0.023 15.0 0.0 0.048 14.0 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator MarR PF01047.22 EPA06243.1 - 0.03 14.2 0.0 0.099 12.6 0.0 1.9 2 0 0 2 2 2 0 MarR family HTH_24 PF13412.6 EPA06243.1 - 0.051 13.1 0.0 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_Mga PF08280.11 EPA06243.1 - 0.096 12.7 0.0 6.7 6.8 0.0 2.5 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain MTS PF05175.14 EPA06243.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 EPA06243.1 - 0.19 12.4 0.0 0.39 11.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain He_PIG PF05345.12 EPA06245.1 - 8.2e-05 22.7 1.2 8.2e-05 22.7 1.2 3.6 3 2 0 3 3 3 1 Putative Ig domain Trypan_PARP PF05887.11 EPA06245.1 - 9.5e-05 22.4 7.9 0.00015 21.8 7.9 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) TonB_N PF16031.5 EPA06245.1 - 0.0035 17.9 12.1 0.0066 17.0 12.1 1.4 1 0 0 1 1 1 1 TonB polyproline region fn3 PF00041.21 EPA06245.1 - 0.011 16.0 5.7 0.27 11.6 0.9 2.5 2 1 0 2 2 2 0 Fibronectin type III domain DUF1910 PF08928.10 EPA06246.1 - 0.2 11.7 3.5 0.19 11.7 0.3 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1910) SpoIIM PF01944.17 EPA06247.1 - 1.9e-05 24.8 17.9 2.8e-05 24.2 17.9 1.2 1 0 0 1 1 1 1 Stage II sporulation protein M NIR_SIR_ferr PF03460.17 EPA06248.1 - 7.1e-17 61.0 0.0 1.1e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Thi4 PF01946.17 EPA06250.1 - 1e-64 218.0 0.1 1.3e-64 217.7 0.1 1.1 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 EPA06250.1 - 1.6e-13 50.5 0.3 1e-06 28.1 0.0 3.0 2 1 1 3 3 3 2 FAD binding domain FAD_oxidored PF12831.7 EPA06250.1 - 1.3e-09 38.0 0.0 2.7e-09 36.9 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EPA06250.1 - 3.9e-08 32.9 0.0 5.2e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EPA06250.1 - 1.9e-07 31.2 0.0 4.2e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EPA06250.1 - 2e-06 27.3 0.0 3.3e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EPA06250.1 - 2.3e-06 27.5 0.2 0.00028 20.6 0.1 2.3 1 1 1 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EPA06250.1 - 2.9e-06 26.3 0.0 4.1e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 EPA06250.1 - 0.0001 21.7 0.0 0.00015 21.1 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EPA06250.1 - 0.00015 20.9 0.4 0.0019 17.3 0.0 2.3 2 1 1 3 3 3 1 Lycopene cyclase protein GIDA PF01134.22 EPA06250.1 - 0.0003 20.0 0.1 0.0005 19.3 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 EPA06250.1 - 0.0062 15.4 0.0 1.3 7.8 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase Amino_oxidase PF01593.24 EPA06250.1 - 0.01 15.2 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase AlaDh_PNT_C PF01262.21 EPA06250.1 - 0.01 15.1 0.0 0.025 13.9 0.1 1.5 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EPA06250.1 - 0.017 15.7 0.1 0.064 13.8 0.0 2.1 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 EPA06250.1 - 0.054 12.0 0.0 0.1 11.1 0.0 1.4 1 0 0 1 1 1 0 GDP dissociation inhibitor NAD_binding_9 PF13454.6 EPA06250.1 - 0.071 13.1 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding TrkA_N PF02254.18 EPA06250.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Usp PF00582.26 EPA06251.1 - 1.9e-29 103.0 0.0 2.1e-29 102.8 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family Hydrolase PF00702.26 EPA06252.1 - 8.5e-10 39.3 0.5 1.6e-09 38.4 0.2 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EPA06252.1 - 0.00064 19.5 0.3 0.00079 19.2 0.3 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF5423 PF17461.2 EPA06252.1 - 0.6 8.9 4.2 0.72 8.6 4.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5423) MOFRL PF05161.13 EPA06253.1 - 8.3e-06 26.0 0.1 8.3e-06 26.0 0.1 1.0 1 0 0 1 1 1 1 MOFRL family DUF4940 PF16298.5 EPA06253.1 - 0.018 14.7 0.2 0.018 14.7 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4940) DUF521 PF04412.13 EPA06254.1 - 8.1e-64 215.8 0.1 1.2e-63 215.3 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF521) HATPase_c PF02518.26 EPA06257.1 - 3.1e-22 79.2 0.1 6.5e-22 78.2 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EPA06257.1 - 1.4e-09 37.8 0.0 5.9e-09 35.8 0.0 2.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EPA06257.1 - 1.6e-09 37.6 0.8 1.2e-08 34.8 0.0 2.6 2 1 1 3 3 3 1 GHKL domain HAMP PF00672.25 EPA06257.1 - 4.1e-09 36.7 0.0 1.8e-08 34.6 0.0 2.2 2 0 0 2 2 2 1 HAMP domain 4HB_MCP_1 PF12729.7 EPA06257.1 - 0.0036 16.9 7.8 0.0036 16.9 7.8 2.8 3 1 0 3 3 3 1 Four helix bundle sensory module for signal transduction HATPase_c_3 PF13589.6 EPA06257.1 - 0.043 13.6 0.1 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GRA6 PF05084.13 EPA06258.1 - 0.02 14.9 5.7 0.021 14.8 5.7 1.0 1 0 0 1 1 1 0 Granule antigen protein (GRA6) Response_reg PF00072.24 EPA06259.1 - 7e-24 84.2 1.0 1.8e-23 82.9 1.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain TrmB PF01978.19 EPA06259.1 - 6.8e-14 51.5 0.0 1.8e-13 50.1 0.0 1.8 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 EPA06259.1 - 3.9e-05 23.0 1.3 5.2e-05 22.5 0.4 1.6 2 0 0 2 2 2 1 Archaeal transcriptional regulator TrmB Adenine_glyco PF03352.13 EPA06259.1 - 0.11 12.2 1.5 10 5.9 0.1 2.5 2 0 0 2 2 2 0 Methyladenine glycosylase DisA-linker PF10635.9 EPA06259.1 - 0.6 9.9 6.3 5 6.9 0.8 2.9 3 0 0 3 3 3 0 DisA bacterial checkpoint controller linker region Pirin PF02678.16 EPA06261.1 - 1.5e-36 124.6 0.3 2.7e-36 123.8 0.3 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EPA06261.1 - 4.1e-32 110.6 0.1 1.6e-30 105.5 0.0 2.5 3 0 0 3 3 3 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EPA06261.1 - 0.0019 17.9 2.0 0.55 10.0 0.4 3.0 3 0 0 3 3 3 2 Cupin domain Cas9_b_hairpin PF17893.1 EPA06261.1 - 0.15 11.8 0.0 0.34 10.7 0.0 1.6 1 0 0 1 1 1 0 CRISPR-associated endonuclease Cas9 beta-hairpin domain VWA PF00092.28 EPA06262.1 - 5.2e-24 85.4 0.8 1.1e-23 84.4 0.8 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EPA06262.1 - 2.1e-16 60.5 0.1 6.9e-16 58.8 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 EPA06262.1 - 0.0077 16.4 0.0 0.019 15.1 0.0 1.6 1 1 0 1 1 1 1 vWA found in TerF C terminus VWA_3 PF13768.6 EPA06262.1 - 0.041 13.8 0.0 0.12 12.3 0.0 1.9 2 1 0 2 2 2 0 von Willebrand factor type A domain DUF1194 PF06707.11 EPA06262.1 - 0.099 11.8 0.2 1.4 8.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1194) Big_9 PF17963.1 EPA06264.1 - 7.6e-21 74.7 25.8 5.3e-18 65.5 8.2 3.1 3 1 0 3 3 3 2 Bacterial Ig domain Cadherin_4 PF17803.1 EPA06264.1 - 4.9e-18 65.5 17.5 1.1e-14 54.8 6.5 3.6 4 1 0 4 4 4 2 Bacterial cadherin-like domain Cadherin_5 PF17892.1 EPA06264.1 - 9.4e-16 57.6 5.6 9.4e-16 57.6 5.6 2.0 3 0 0 3 3 3 1 Cadherin-like domain Mtf2_C PF14061.6 EPA06264.1 - 0.12 12.5 0.0 0.82 9.9 0.0 2.0 2 0 0 2 2 2 0 Polycomb-like MTF2 factor 2 FMN_red PF03358.15 EPA06265.1 - 1.6e-39 135.1 0.0 2e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EPA06265.1 - 8.4e-09 35.4 0.0 1.1e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Pyr_redox PF00070.27 EPA06265.1 - 0.11 13.1 0.0 0.28 11.8 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HxlR PF01638.17 EPA06266.1 - 1.1e-24 86.1 1.4 1.3e-24 85.9 1.4 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_34 PF13601.6 EPA06266.1 - 0.0046 17.1 0.1 0.0065 16.6 0.1 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain DUF5389 PF17364.2 EPA06269.1 - 0.006 16.6 0.1 0.0068 16.4 0.1 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5389) Inhibitor_I71 PF12628.7 EPA06271.1 - 9.8e-05 22.3 0.2 0.00011 22.0 0.2 1.1 1 0 0 1 1 1 1 Falstatin, cysteine peptidase inhibitor UvrA_inter PF17760.1 EPA06272.1 - 1.1e-36 125.2 0.6 1.5e-36 124.7 0.6 1.2 1 0 0 1 1 1 1 UvrA interaction domain Calmodulin_bind PF07887.11 EPA06272.1 - 0.085 12.1 0.1 0.12 11.7 0.1 1.2 1 0 0 1 1 1 0 Calmodulin binding protein-like zf-ribbon_3 PF13248.6 EPA06272.1 - 0.13 11.8 0.1 0.13 11.8 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 EPA06272.1 - 0.22 11.3 4.4 6.3 6.6 0.4 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Sgf11 PF08209.11 EPA06272.1 - 0.52 9.9 2.5 1.4 8.5 0.3 2.1 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) UvrA_inter PF17760.1 EPA06273.1 - 1.3e-05 25.2 0.1 2e-05 24.6 0.1 1.3 1 0 0 1 1 1 1 UvrA interaction domain BsuBI_PstI_RE_N PF17728.1 EPA06273.1 - 0.12 12.2 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease HTH domain UvrA_inter PF17760.1 EPA06274.1 - 2.3e-14 53.4 0.1 2.6e-14 53.2 0.1 1.1 1 0 0 1 1 1 1 UvrA interaction domain zf-ribbon_3 PF13248.6 EPA06274.1 - 0.019 14.3 0.1 0.032 13.7 0.1 1.4 1 0 0 1 1 1 0 zinc-ribbon domain UvrC_HhH_N PF08459.11 EPA06275.1 - 1.1e-45 155.3 0.3 1.9e-45 154.5 0.0 1.6 2 0 0 2 2 2 1 UvrC Helix-hairpin-helix N-terminal UVR PF02151.19 EPA06275.1 - 1.2e-08 34.4 0.4 2.3e-08 33.5 0.4 1.5 1 0 0 1 1 1 1 UvrB/uvrC motif PcrB PF01884.17 EPA06276.1 - 2.9e-25 89.1 0.0 3.3e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 PcrB family Gln-synt_C PF00120.24 EPA06277.1 - 3.3e-115 384.8 0.0 3.8e-115 384.6 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain DUF3792 PF12670.7 EPA06278.1 - 0.026 14.7 10.2 0.031 14.5 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) SHMT PF00464.19 EPA06279.1 - 2.5e-77 260.1 0.0 3.6e-77 259.6 0.0 1.2 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 EPA06279.1 - 1.6e-07 30.9 0.0 1e-06 28.2 0.0 2.2 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EPA06279.1 - 2.9e-05 23.5 0.0 9e-05 21.9 0.0 1.8 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EPA06279.1 - 0.0017 17.4 0.0 0.0033 16.4 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-V SelA PF03841.13 EPA06279.1 - 0.006 15.6 0.0 0.0097 14.9 0.0 1.3 1 0 0 1 1 1 1 L-seryl-tRNA selenium transferase HetR_C PF18460.1 EPA06280.1 - 0.021 14.7 0.6 0.043 13.7 0.3 1.6 2 0 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain FliH PF02108.16 EPA06280.1 - 0.038 14.0 0.3 0.088 12.9 0.0 1.7 2 1 0 2 2 2 0 Flagellar assembly protein FliH AAA_22 PF13401.6 EPA06281.1 - 1e-11 45.2 0.0 2.1e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EPA06281.1 - 1.3e-11 45.0 1.4 5.9e-11 42.9 0.5 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EPA06281.1 - 2.6e-08 34.5 0.0 4.7e-07 30.3 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 EPA06281.1 - 5.5e-07 29.2 0.1 8.7e-07 28.5 0.1 1.3 1 0 0 1 1 1 1 Bacterial TniB protein NACHT PF05729.12 EPA06281.1 - 7.4e-07 29.2 0.0 1.1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 EPA06281.1 - 7.7e-06 26.0 3.9 1.4e-05 25.1 2.2 2.2 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea DUF2075 PF09848.9 EPA06281.1 - 5.2e-05 22.6 0.0 7.2e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.14 EPA06281.1 - 0.0002 20.6 0.1 0.0005 19.3 0.0 1.6 2 0 0 2 2 2 1 PIF1-like helicase KAP_NTPase PF07693.14 EPA06281.1 - 0.00021 20.7 0.2 0.36 10.0 0.0 2.4 2 0 0 2 2 2 2 KAP family P-loop domain AAA_5 PF07728.14 EPA06281.1 - 0.00029 20.9 0.1 0.00092 19.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EPA06281.1 - 0.00048 19.4 0.0 0.0012 18.1 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.6 EPA06281.1 - 0.00056 20.3 0.1 0.0014 18.9 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EPA06281.1 - 0.0008 19.0 0.0 0.0023 17.5 0.0 1.8 2 0 0 2 2 1 1 P-loop containing dynein motor region AAA_32 PF13654.6 EPA06281.1 - 0.00096 18.1 0.4 0.16 10.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 EPA06281.1 - 0.0016 17.9 0.5 0.36 10.1 0.0 2.5 2 1 0 2 2 2 1 KaiC RNA_helicase PF00910.22 EPA06281.1 - 0.0029 18.0 0.0 0.0077 16.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase NB-ARC PF00931.22 EPA06281.1 - 0.0035 16.6 0.0 0.0068 15.6 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain NTPase_1 PF03266.15 EPA06281.1 - 0.0055 16.6 0.3 0.13 12.1 0.1 2.4 2 0 0 2 2 2 1 NTPase AAA_11 PF13086.6 EPA06281.1 - 0.01 15.6 0.0 0.01 15.6 0.0 1.9 2 1 0 2 2 2 0 AAA domain TIP49_C PF17856.1 EPA06281.1 - 0.017 15.3 0.0 0.043 14.0 0.0 1.8 1 0 0 1 1 1 0 TIP49 AAA-lid domain ResIII PF04851.15 EPA06281.1 - 0.017 15.2 0.2 0.35 10.8 0.0 2.3 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_assoc_2 PF16193.5 EPA06281.1 - 0.019 15.3 0.1 0.052 13.9 0.1 1.7 1 0 0 1 1 1 0 AAA C-terminal domain AAA_24 PF13479.6 EPA06281.1 - 0.029 14.1 0.1 0.1 12.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EPA06281.1 - 0.031 13.7 0.0 0.066 12.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EPA06281.1 - 0.05 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain TrwB_AAD_bind PF10412.9 EPA06281.1 - 0.052 12.5 0.0 0.12 11.2 0.0 1.6 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain TsaE PF02367.17 EPA06281.1 - 0.067 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 EPA06281.1 - 0.077 12.0 0.0 0.18 10.8 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Tfb5 PF06331.12 EPA06281.1 - 0.081 12.9 5.0 8 6.5 0.1 3.2 3 0 0 3 3 3 0 Transcription factor TFIIH complex subunit Tfb5 AAA_30 PF13604.6 EPA06281.1 - 0.084 12.6 0.2 0.44 10.2 0.0 2.1 2 1 0 2 2 2 0 AAA domain HTH_27 PF13463.6 EPA06282.1 - 3.7e-06 27.3 0.1 6.4e-06 26.6 0.1 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.19 EPA06282.1 - 0.00018 21.4 0.1 0.00042 20.1 0.1 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB DUF4364 PF14277.6 EPA06282.1 - 0.0025 17.6 1.8 0.005 16.6 0.1 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF4364) HTH_34 PF13601.6 EPA06282.1 - 0.0038 17.4 1.3 0.0058 16.8 0.3 1.7 2 0 0 2 2 2 1 Winged helix DNA-binding domain DUF3116 PF11313.8 EPA06282.1 - 0.0072 16.2 3.7 0.012 15.5 1.2 2.6 1 1 0 2 2 2 1 Protein of unknown function (DUF3116) Replic_Relax PF13814.6 EPA06282.1 - 0.009 16.1 0.1 0.015 15.3 0.1 1.3 1 0 0 1 1 1 1 Replication-relaxation MarR PF01047.22 EPA06282.1 - 0.011 15.7 0.1 0.026 14.5 0.1 1.6 1 0 0 1 1 1 0 MarR family HTH_45 PF14947.6 EPA06282.1 - 0.022 14.7 3.0 0.041 13.9 0.8 2.4 2 1 1 3 3 3 0 Winged helix-turn-helix MBG PF17883.1 EPA06282.1 - 0.038 14.6 1.0 0.071 13.7 1.0 1.5 1 1 0 1 1 1 0 MBG domain DUF5376 PF17346.2 EPA06282.1 - 0.055 13.8 2.7 0.59 10.5 0.4 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5376) HTH_Crp_2 PF13545.6 EPA06282.1 - 0.084 12.9 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain PolC_DP2 PF03833.13 EPA06283.1 - 2.3e-138 462.5 0.2 2.9e-138 462.2 0.2 1.0 1 0 0 1 1 1 1 DNA polymerase II large subunit DP2 PolC_DP2 PF03833.13 EPA06284.1 - 7.4e-170 566.7 0.0 9.5e-170 566.4 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase II large subunit DP2 Acetyltransf_19 PF18015.1 EPA06284.1 - 0.031 14.5 0.1 0.12 12.6 0.1 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain zinc-ribbons_6 PF07191.12 EPA06284.1 - 0.19 11.7 16.2 9.4 6.3 0.1 2.9 2 1 0 2 2 2 0 zinc-ribbons PcrB PF01884.17 EPA06285.1 - 4.4e-05 23.1 0.0 4.7e-05 22.9 0.0 1.0 1 0 0 1 1 1 1 PcrB family His_biosynth PF00977.21 EPA06285.1 - 0.0015 18.0 0.0 0.0016 17.9 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Penicillinase_R PF03965.16 EPA06286.1 - 0.0027 18.0 0.0 0.0042 17.4 0.0 1.3 1 0 0 1 1 1 1 Penicillinase repressor MazE_antitoxin PF04014.18 EPA06287.1 - 2.9e-07 30.3 0.1 3.5e-07 30.0 0.1 1.1 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin Rubredoxin_C PF18267.1 EPA06287.1 - 0.0056 16.6 0.1 0.0075 16.2 0.1 1.1 1 0 0 1 1 1 1 Rubredoxin NAD+ reductase C-terminal domain eIF-1a PF01176.19 EPA06287.1 - 0.078 12.8 0.0 0.13 12.1 0.0 1.6 1 1 0 1 1 1 0 Translation initiation factor 1A / IF-1 Cpn60_TCP1 PF00118.24 EPA06288.1 - 2.7e-184 613.4 21.4 3.1e-184 613.2 21.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Dak2 PF02734.17 EPA06288.1 - 0.00014 21.8 3.0 0.0033 17.3 2.0 2.4 2 0 0 2 2 2 1 DAK2 domain ADK PF00406.22 EPA06288.1 - 0.045 13.8 0.9 1.8 8.7 0.2 2.5 1 1 0 2 2 2 0 Adenylate kinase Ustilago_mating PF05722.12 EPA06288.1 - 0.048 13.2 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Ustilago B locus mating-type protein DUF2853 PF11015.8 EPA06288.1 - 0.54 11.0 3.9 0.49 11.1 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2853) LSM PF01423.22 EPA06289.1 - 1.6e-11 43.7 0.4 1.7e-11 43.7 0.4 1.0 1 0 0 1 1 1 1 LSM domain S-AdoMet_synt_N PF00438.20 EPA06290.1 - 2.3e-41 140.5 0.2 2.8e-41 140.2 0.2 1.1 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 EPA06290.1 - 5.9e-09 36.2 1.5 4.3e-07 30.2 0.2 2.2 2 0 0 2 2 2 2 S-adenosylmethionine synthetase, central domain AdoMet_Synthase PF01941.19 EPA06290.1 - 0.0025 16.7 0.4 0.093 11.5 0.2 2.0 1 1 1 2 2 2 2 S-adenosylmethionine synthetase (AdoMet synthetase) Rad51 PF08423.11 EPA06291.1 - 1.1e-10 41.2 0.2 1.1e-10 41.2 0.2 1.0 1 0 0 1 1 1 1 Rad51 ATPase PF06745.13 EPA06291.1 - 1.4e-08 34.4 0.7 1.5e-08 34.3 0.7 1.0 1 0 0 1 1 1 1 KaiC RecA PF00154.21 EPA06291.1 - 3.8e-06 26.6 0.1 3.8e-06 26.6 0.1 1.0 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ABC_tran PF00005.27 EPA06291.1 - 0.00064 20.3 0.1 0.00068 20.2 0.1 1.0 1 0 0 1 1 1 1 ABC transporter AAA_25 PF13481.6 EPA06291.1 - 0.0016 18.0 0.0 0.0017 17.9 0.0 1.0 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EPA06291.1 - 0.0035 17.3 0.0 0.0035 17.3 0.0 1.0 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EPA06291.1 - 0.0047 16.7 0.0 0.0047 16.7 0.0 1.1 1 0 0 1 1 1 1 IstB-like ATP binding protein DnaB_C PF03796.15 EPA06291.1 - 0.035 13.5 0.0 0.041 13.2 0.0 1.0 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_16 PF13191.6 EPA06291.1 - 0.039 14.3 0.0 0.039 14.3 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EPA06291.1 - 0.071 12.8 0.1 0.075 12.7 0.1 1.1 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EPA06291.1 - 0.075 12.2 0.1 0.078 12.1 0.1 1.0 1 0 0 1 1 1 0 NB-ARC domain UvrD-helicase PF00580.21 EPA06291.1 - 0.075 12.5 0.0 0.081 12.4 0.0 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain PhoH PF02562.16 EPA06291.1 - 0.082 12.4 0.0 0.084 12.3 0.0 1.1 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.9 EPA06291.1 - 0.18 11.0 0.1 0.2 10.9 0.1 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Rad51 PF08423.11 EPA06293.1 - 1.4e-10 40.9 0.5 1.6e-10 40.7 0.5 1.1 1 0 0 1 1 1 1 Rad51 Rad51 PF08423.11 EPA06295.1 - 6.4e-12 45.3 0.3 7.6e-12 45.0 0.3 1.1 1 0 0 1 1 1 1 Rad51 RepA_C PF04796.12 EPA06295.1 - 0.14 12.2 0.6 0.18 11.8 0.6 1.2 1 0 0 1 1 1 0 Plasmid encoded RepA protein SBP_bac_5 PF00496.22 EPA06299.1 - 5.2e-16 58.6 0.0 6.5e-16 58.3 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle DUF4355 PF14265.6 EPA06300.1 - 0.039 14.2 0.7 0.039 14.2 0.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) SBP_bac_5 PF00496.22 EPA06301.1 - 5.5e-16 58.5 0.0 6.7e-16 58.2 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle NAD_binding_2 PF03446.15 EPA06302.1 - 4.4e-05 23.7 0.0 4.4e-05 23.7 0.0 1.0 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 EPA06302.1 - 7e-05 22.5 0.0 7.6e-05 22.4 0.0 1.0 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 EPA06302.1 - 0.0019 17.6 0.0 0.0019 17.6 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 EPA06302.1 - 0.0095 16.2 0.0 0.01 16.1 0.0 1.0 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.21 EPA06302.1 - 0.014 14.9 0.0 0.014 14.9 0.0 1.0 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 EPA06302.1 - 0.017 15.7 0.0 0.017 15.7 0.0 1.0 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox_2 PF07992.14 EPA06302.1 - 0.023 13.9 0.0 0.023 13.9 0.0 1.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 EPA06302.1 - 0.056 13.0 0.0 0.059 13.0 0.0 1.0 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 EPA06302.1 - 0.095 12.6 0.0 0.095 12.6 0.0 1.0 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EPA06302.1 - 0.11 12.7 0.0 0.13 12.5 0.0 1.1 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_Gly3P_dh_N PF01210.23 EPA06302.1 - 0.12 12.4 0.0 0.12 12.3 0.0 1.0 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AlaDh_PNT_C PF01262.21 EPA06302.1 - 0.17 11.2 0.0 0.17 11.2 0.0 1.0 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Nitroreductase PF00881.24 EPA06303.1 - 5e-33 114.5 0.0 6.5e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 EPA06303.1 - 1.3e-10 41.2 0.3 6.4e-05 22.6 0.4 2.8 2 1 0 2 2 2 2 Putative TM nitroreductase DUF1951 PF09188.10 EPA06303.1 - 0.018 15.0 0.1 0.025 14.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1951) Zeta_toxin PF06414.12 EPA06303.1 - 0.16 11.2 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DZR PF12773.7 EPA06304.1 - 0.024 14.7 7.9 0.096 12.7 7.9 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-dskA_traR PF01258.17 EPA06304.1 - 0.065 13.2 3.6 1.7 8.6 0.3 2.3 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger GDH_N PF12466.8 EPA06304.1 - 0.23 11.7 0.0 0.3 11.3 0.0 1.2 1 0 0 1 1 1 0 Glutamate dehydrogenase N terminal DUF983 PF06170.12 EPA06304.1 - 0.32 11.4 3.5 0.74 10.3 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF983) zinc_ribbon_2 PF13240.6 EPA06304.1 - 0.51 10.1 7.3 2.4 8.0 0.8 2.6 3 0 0 3 3 3 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 EPA06304.1 - 1.2 9.1 5.2 1.3 9.0 0.4 2.1 1 1 1 2 2 2 0 Putative transposase DNA-binding domain RNA_POL_M_15KD PF02150.16 EPA06304.1 - 2.3 8.2 8.5 0.55 10.2 3.8 2.3 2 1 0 2 2 2 0 RNA polymerases M/15 Kd subunit Methyltransf_25 PF13649.6 EPA06305.1 - 2.8e-16 60.0 0.0 4.2e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA06305.1 - 3.5e-15 56.1 0.2 4.7e-15 55.7 0.2 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA06305.1 - 1.2e-14 54.7 0.0 1.5e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EPA06305.1 - 1.5e-13 50.7 0.0 1.5e-13 50.6 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EPA06305.1 - 1.4e-11 45.0 0.1 2.2e-11 44.3 0.0 1.4 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EPA06305.1 - 6e-08 32.7 0.0 8.7e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EPA06305.1 - 8e-08 32.0 0.0 2.2e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EPA06305.1 - 2.2e-07 30.6 0.1 2.9e-07 30.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.14 EPA06305.1 - 1.1e-06 28.2 0.1 1.3e-06 28.0 0.1 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB NodS PF05401.11 EPA06305.1 - 2.6e-06 27.2 0.0 3.1e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_9 PF08003.11 EPA06305.1 - 0.00024 20.1 0.0 0.00027 20.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 EPA06305.1 - 0.0017 17.7 0.0 0.0023 17.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.6 EPA06305.1 - 0.015 16.3 0.0 0.021 15.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 EPA06305.1 - 0.017 14.6 0.0 0.03 13.8 0.0 1.4 2 0 0 2 2 2 0 Putative methyltransferase GidB PF02527.15 EPA06305.1 - 0.026 13.9 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_32 PF13679.6 EPA06305.1 - 0.04 13.9 0.0 0.052 13.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 EPA06305.1 - 0.056 12.5 0.0 0.066 12.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase ADH_zinc_N PF00107.26 EPA06305.1 - 0.081 12.9 0.0 0.24 11.4 0.0 1.9 2 1 0 2 2 2 0 Zinc-binding dehydrogenase MetW PF07021.12 EPA06305.1 - 0.14 11.7 0.0 0.19 11.3 0.0 1.1 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PCMT PF01135.19 EPA06305.1 - 0.18 11.5 0.1 0.31 10.8 0.1 1.5 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CPSase_L_D2 PF02786.17 EPA06306.1 - 1.6e-27 96.4 0.0 2.3e-27 95.9 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EPA06306.1 - 8.1e-23 81.1 0.0 1.9e-22 79.9 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain MGS PF02142.22 EPA06306.1 - 1.3e-14 54.1 0.5 2.8e-13 49.9 0.0 2.7 2 0 0 2 2 2 1 MGS-like domain ATP-grasp PF02222.22 EPA06306.1 - 8.3e-10 38.5 0.0 1.4e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 EPA06306.1 - 5.4e-09 35.9 0.0 1.4e-08 34.6 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.13 EPA06306.1 - 9.7e-09 35.1 0.0 1.8e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus GARS_A PF01071.19 EPA06306.1 - 3.1e-05 23.9 0.0 0.00011 22.1 0.0 1.9 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain TrkA_N PF02254.18 EPA06306.1 - 0.0015 18.8 0.0 0.0058 16.9 0.0 2.0 2 0 0 2 2 2 1 TrkA-N domain ATP-grasp_4 PF13535.6 EPA06306.1 - 0.0032 17.1 0.1 0.013 15.1 0.2 2.0 2 1 0 2 2 2 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EPA06306.1 - 0.0055 16.8 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain DUF327 PF03885.13 EPA06307.1 - 0.038 14.0 1.8 0.04 13.9 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF327) DUF2407_C PF13373.6 EPA06308.1 - 0.056 13.6 0.0 0.082 13.1 0.0 1.2 1 0 0 1 1 1 0 DUF2407 C-terminal domain YjgF_endoribonc PF14588.6 EPA06309.1 - 7e-33 113.9 0.0 7.6e-33 113.7 0.0 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.21 EPA06309.1 - 1.8e-21 76.4 0.0 2.2e-21 76.1 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP BON PF04972.17 EPA06309.1 - 0.063 13.6 0.6 0.58 10.5 0.1 2.5 1 1 0 2 2 2 0 BON domain MOEP19 PF16005.5 EPA06309.1 - 0.17 11.9 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 KH-like RNA-binding domain DUF5382 PF17354.2 EPA06309.1 - 0.22 10.3 0.0 0.3 9.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5382) TrmB PF01978.19 EPA06310.1 - 5.8e-17 61.3 0.3 1e-15 57.3 0.2 2.4 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB DUF327 PF03885.13 EPA06310.1 - 0.041 13.9 0.4 0.041 13.9 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF327) HTH_IclR PF09339.10 EPA06310.1 - 0.18 11.6 0.0 0.56 10.1 0.0 1.8 1 0 0 1 1 1 0 IclR helix-turn-helix domain ATP-synt_F PF01990.17 EPA06311.1 - 8.2e-14 51.7 0.0 9.2e-14 51.5 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit Trp_syntA PF00290.20 EPA06311.1 - 0.00046 19.1 0.0 0.00048 19.1 0.0 1.0 1 0 0 1 1 1 1 Tryptophan synthase alpha chain LUD_dom PF02589.15 EPA06311.1 - 0.056 13.2 0.0 0.056 13.2 0.0 1.1 1 0 0 1 1 1 0 LUD domain UBA_3 PF09288.10 EPA06312.1 - 0.015 15.1 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Herpes_U55 PF06501.11 EPA06312.1 - 0.038 12.8 0.0 0.039 12.8 0.0 1.0 1 0 0 1 1 1 0 Human herpesvirus U55 protein CPSase_L_D2 PF02786.17 EPA06314.1 - 6.1e-72 241.5 0.2 7.9e-72 241.2 0.2 1.1 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EPA06314.1 - 2.1e-07 31.3 0.0 5.2e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 EPA06314.1 - 1e-06 28.4 0.2 1.5e-06 27.9 0.2 1.2 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EPA06314.1 - 3.7e-06 26.6 0.2 6.6e-06 25.8 0.2 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EPA06314.1 - 0.0042 16.8 0.0 0.0078 16.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon GARS_A PF01071.19 EPA06314.1 - 0.0084 15.9 0.1 0.014 15.1 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_2 PF08442.10 EPA06314.1 - 0.03 13.9 0.4 0.083 12.4 0.1 1.9 3 0 0 3 3 3 0 ATP-grasp domain ATP-grasp_5 PF13549.6 EPA06314.1 - 0.1 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain ADH_N PF08240.12 EPA06315.1 - 6e-24 84.0 2.2 9.7e-24 83.4 1.9 1.5 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 EPA06315.1 - 0.03 13.8 0.0 0.047 13.2 0.0 1.2 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus CPSase_sm_chain PF00988.22 EPA06316.1 - 2.6e-43 146.9 0.0 1.2e-42 144.7 0.0 2.0 2 1 0 2 2 2 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EPA06316.1 - 7e-43 146.6 0.1 1e-42 146.1 0.1 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EPA06316.1 - 7.7e-08 32.3 0.3 5.4e-06 26.3 0.3 2.3 1 1 0 1 1 1 1 Peptidase C26 Thump_like PF18096.1 EPA06316.1 - 0.18 11.7 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 THUMP domain-like DHHA1 PF02272.19 EPA06318.1 - 4.3e-16 59.6 0.4 4.3e-16 59.6 0.4 2.2 3 0 0 3 3 3 1 DHHA1 domain DHH PF01368.20 EPA06318.1 - 0.00024 21.3 1.8 0.00048 20.3 1.4 1.7 2 0 0 2 2 2 1 DHH family HD_3 PF13023.6 EPA06318.1 - 0.074 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 HD domain DeoC PF01791.9 EPA06319.1 - 1.2e-06 28.3 0.0 1.5e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase ThiG PF05690.14 EPA06319.1 - 0.0084 15.4 0.1 0.0097 15.2 0.1 1.0 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG DUF561 PF04481.12 EPA06319.1 - 0.054 12.7 0.0 0.06 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF561) Citrate_synt PF00285.21 EPA06320.1 - 1.1e-130 435.9 0.0 1.3e-130 435.7 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DUF1940 PF09155.10 EPA06320.1 - 0.11 12.6 0.0 0.55 10.3 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1940) FrhB_FdhB_N PF04422.13 EPA06320.1 - 0.17 12.1 0.2 0.39 10.9 0.2 1.7 1 1 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term Metallophos PF00149.28 EPA06322.1 - 1.3e-08 35.6 0.2 5.7e-08 33.5 0.2 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EPA06322.1 - 1.3e-06 28.7 0.1 2e-06 28.1 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Epimerase_2 PF02350.19 EPA06322.1 - 0.016 14.1 0.0 0.032 13.1 0.0 1.5 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase Metallophos_3 PF14582.6 EPA06322.1 - 0.03 13.6 0.1 0.71 9.1 0.1 2.1 1 1 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily DNA_pol_E_B PF04042.16 EPA06322.1 - 0.054 12.8 0.1 0.3 10.4 0.0 2.2 2 1 0 2 2 2 0 DNA polymerase alpha/epsilon subunit B ADH_zinc_N PF00107.26 EPA06324.1 - 9.6e-15 54.7 0.0 1.3e-14 54.3 0.0 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EPA06324.1 - 1.5e-07 32.5 0.0 1.9e-07 32.2 0.0 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EPA06324.1 - 2.2e-06 27.3 0.2 2.7e-06 27.0 0.2 1.1 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus DASH_Spc19 PF08287.11 EPA06325.1 - 0.0069 16.3 0.9 0.0069 16.3 0.9 1.6 2 0 0 2 2 2 1 Spc19 Syntaxin_2 PF14523.6 EPA06325.1 - 1.6 9.1 9.0 0.12 12.7 1.9 2.5 1 1 1 2 2 2 0 Syntaxin-like protein SWIM PF04434.17 EPA06326.1 - 0.071 12.8 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 SWIM zinc finger DeoC PF01791.9 EPA06327.1 - 3.2e-11 43.3 0.0 3.9e-11 43.0 0.0 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase AAA PF00004.29 EPA06329.1 - 1.5e-37 129.0 0.0 3.3e-37 127.9 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.18 EPA06329.1 - 1.8e-07 31.1 0.1 3.5e-07 30.2 0.1 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_2 PF07724.14 EPA06329.1 - 2.4e-07 31.0 0.0 4.9e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Vps4_C PF09336.10 EPA06329.1 - 3.8e-07 30.0 0.1 7.8e-06 25.8 0.0 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EPA06329.1 - 3.1e-05 23.7 0.0 9.2e-05 22.2 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EPA06329.1 - 4.5e-05 23.9 0.0 0.0077 16.6 0.0 2.6 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EPA06329.1 - 4.9e-05 23.1 0.0 0.00012 21.8 0.0 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EPA06329.1 - 7.4e-05 23.0 0.0 0.004 17.4 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EPA06329.1 - 0.00076 19.3 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EPA06329.1 - 0.0013 18.3 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 EPA06329.1 - 0.0022 18.0 0.0 0.016 15.2 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EPA06329.1 - 0.0041 17.2 0.0 0.067 13.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EPA06329.1 - 0.005 16.8 0.3 2.2 8.1 0.0 2.8 2 1 1 3 3 2 1 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 EPA06329.1 - 0.0052 16.2 0.1 0.012 15.1 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EPA06329.1 - 0.008 16.3 0.0 0.034 14.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EPA06329.1 - 0.0084 15.4 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_25 PF13481.6 EPA06329.1 - 0.012 15.2 0.0 0.033 13.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EPA06329.1 - 0.017 14.9 0.0 0.032 14.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 EPA06329.1 - 0.023 14.0 0.0 0.067 12.5 0.0 1.8 1 1 0 1 1 1 0 Zeta toxin AAA_11 PF13086.6 EPA06329.1 - 0.047 13.5 0.0 0.13 12.0 0.0 1.7 1 1 1 2 2 2 0 AAA domain ATPase PF06745.13 EPA06329.1 - 0.047 13.0 0.1 1.8 7.8 0.1 2.3 1 1 1 2 2 2 0 KaiC KAP_NTPase PF07693.14 EPA06329.1 - 0.071 12.3 0.0 1.1 8.4 0.0 2.1 1 1 1 2 2 2 0 KAP family P-loop domain Parvo_NS1 PF01057.17 EPA06329.1 - 0.11 11.6 0.0 0.26 10.4 0.0 1.7 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 RNA_helicase PF00910.22 EPA06329.1 - 0.12 12.8 0.0 0.41 11.1 0.0 2.0 1 0 0 1 1 1 0 RNA helicase PhoH PF02562.16 EPA06329.1 - 0.17 11.4 0.6 0.36 10.2 0.3 1.7 2 0 0 2 2 1 0 PhoH-like protein TruD PF01142.18 EPA06330.1 - 3.1e-45 154.7 0.1 3.6e-45 154.5 0.1 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) Response_reg PF00072.24 EPA06331.1 - 1.4e-16 60.7 0.0 2.5e-16 59.9 0.0 1.4 1 1 0 1 1 1 1 Response regulator receiver domain ERCC3_RAD25_C PF16203.5 EPA06331.1 - 0.063 12.5 0.1 0.08 12.1 0.1 1.4 1 1 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Arch_flagellin PF01917.16 EPA06332.1 - 5.6e-23 81.9 5.4 7.8e-23 81.5 5.4 1.2 1 0 0 1 1 1 1 Archaebacterial flagellin DUF5325 PF17259.2 EPA06332.1 - 0.26 11.2 3.4 0.72 9.8 3.4 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5325) Peptidase_M10 PF00413.24 EPA06333.1 - 7.9e-10 38.8 0.0 2.3e-09 37.3 0.0 1.2 1 1 0 1 1 1 1 Matrixin Peptidase_M57 PF12388.8 EPA06333.1 - 9.1e-05 22.2 0.1 0.00015 21.5 0.1 1.3 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Peptidase_M66 PF10462.9 EPA06333.1 - 0.013 14.4 0.0 0.025 13.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_3 PF13582.6 EPA06333.1 - 0.064 13.8 0.0 0.099 13.2 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EPA06333.1 - 0.21 11.2 1.1 0.61 9.7 1.1 1.7 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Arch_flagellin PF01917.16 EPA06334.1 - 1.3e-21 77.5 4.8 1.5e-21 77.3 4.8 1.1 1 0 0 1 1 1 1 Archaebacterial flagellin DUF5325 PF17259.2 EPA06334.1 - 0.098 12.6 2.2 0.23 11.3 2.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5325) HATPase_c PF02518.26 EPA06335.1 - 2.4e-16 60.2 0.8 4.9e-16 59.2 0.1 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 EPA06335.1 - 5.4e-09 35.9 0.3 5.4e-09 35.9 0.3 1.8 2 0 0 2 2 2 1 GHKL domain HisKA PF00512.25 EPA06335.1 - 3.9e-08 33.2 0.7 8.6e-08 32.1 0.7 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 EPA06335.1 - 0.0011 18.7 0.7 0.0025 17.6 0.0 1.9 2 1 1 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EPA06335.1 - 0.021 14.8 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain GAS PF13851.6 EPA06336.1 - 0.014 14.8 0.2 0.014 14.8 0.2 2.6 1 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.11 EPA06336.1 - 0.022 15.1 0.3 0.022 15.1 0.3 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Tropomyosin PF00261.20 EPA06336.1 - 0.041 13.2 4.3 0.57 9.5 0.5 2.3 2 0 0 2 2 2 0 Tropomyosin DUF2388 PF09498.10 EPA06336.1 - 0.063 13.3 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) Tup_N PF08581.10 EPA06336.1 - 0.3 11.4 4.6 0.12 12.7 0.8 2.3 2 1 0 2 2 2 0 Tup N-terminal Tmemb_cc2 PF10267.9 EPA06336.1 - 0.31 10.1 10.9 0.39 9.8 10.9 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF4322 PF14210.6 EPA06336.1 - 0.32 10.9 2.1 0.48 10.3 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4322) Prefoldin_3 PF13758.6 EPA06336.1 - 0.37 10.9 0.1 0.37 10.9 0.1 2.7 2 1 0 2 2 2 0 Prefoldin subunit DivIC PF04977.15 EPA06336.1 - 0.4 10.5 1.9 4.7 7.1 0.3 2.5 3 0 0 3 3 3 0 Septum formation initiator HIP1_clath_bdg PF16515.5 EPA06336.1 - 0.42 11.2 0.2 0.42 11.2 0.2 2.9 1 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cupredoxin_1 PF13473.6 EPA06337.1 - 3.7e-06 27.0 0.0 1e-05 25.6 0.0 1.8 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 EPA06337.1 - 7.8e-06 26.3 0.0 1.9e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Borealin PF10512.9 EPA06338.1 - 0.031 14.2 0.4 0.038 14.0 0.4 1.1 1 0 0 1 1 1 0 Cell division cycle-associated protein 8 Fmp27_WPPW PF10359.9 EPA06338.1 - 0.045 12.6 4.9 0.05 12.4 4.9 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain GIT_CC PF16559.5 EPA06338.1 - 0.046 13.6 4.5 0.074 12.9 1.6 2.1 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Arch_flagellin PF01917.16 EPA06340.1 - 8.1e-22 78.2 11.0 1.1e-21 77.8 11.0 1.2 1 0 0 1 1 1 1 Archaebacterial flagellin DUF2393 PF09624.10 EPA06340.1 - 0.11 12.5 0.5 0.19 11.7 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) DUF5325 PF17259.2 EPA06340.1 - 0.61 10.0 4.5 0.51 10.3 2.8 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5325) TrmB PF01978.19 EPA06343.1 - 5.1e-15 55.1 0.0 1.3e-14 53.8 0.0 1.7 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 EPA06343.1 - 2e-06 27.2 0.2 2.8e-06 26.7 0.2 1.2 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB HTH_5 PF01022.20 EPA06343.1 - 0.0041 16.9 0.0 0.0094 15.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_11 PF08279.12 EPA06343.1 - 0.018 15.0 0.0 0.061 13.3 0.0 1.9 1 0 0 1 1 1 0 HTH domain DUF1386 PF07138.11 EPA06343.1 - 0.03 13.6 0.2 0.083 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1386) Bacillus_HBL PF05791.11 EPA06343.1 - 0.038 13.8 0.3 0.076 12.8 0.3 1.5 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) PNK3P PF08645.11 EPA06343.1 - 0.04 13.6 1.5 0.047 13.4 0.1 1.8 2 1 0 2 2 2 0 Polynucleotide kinase 3 phosphatase Cep57_MT_bd PF06657.13 EPA06343.1 - 0.044 14.2 0.1 0.11 13.0 0.1 1.7 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Pup PF05639.11 EPA06343.1 - 0.19 12.7 0.1 0.41 11.6 0.1 1.6 1 0 0 1 1 1 0 Pup-like protein DUF1059 PF06348.11 EPA06344.1 - 1.4e-06 28.4 0.3 1.4e-06 28.4 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) PAS_9 PF13426.7 EPA06345.1 - 2.5e-18 66.2 2.0 5.4e-18 65.2 0.2 2.4 2 1 0 2 2 2 1 PAS domain HATPase_c PF02518.26 EPA06345.1 - 1.3e-16 61.1 0.3 3e-16 59.9 0.3 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EPA06345.1 - 4.8e-13 48.9 0.3 1.2e-12 47.6 0.3 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 EPA06345.1 - 1.4e-12 47.7 0.2 3.2e-12 46.6 0.2 1.6 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 EPA06345.1 - 5.5e-10 39.3 0.0 2e-09 37.4 0.0 1.9 2 0 0 2 2 2 1 PAS fold HATPase_c_5 PF14501.6 EPA06345.1 - 1.4e-08 34.5 0.5 4.2e-08 33.0 0.5 1.8 1 0 0 1 1 1 1 GHKL domain PAS_4 PF08448.10 EPA06345.1 - 2.2e-08 34.3 0.0 3.3e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.6 EPA06345.1 - 0.00012 22.0 0.2 0.00028 20.7 0.2 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MAPKK1_Int PF08923.10 EPA06345.1 - 0.0031 17.3 0.3 0.018 14.9 0.1 2.2 2 0 0 2 2 2 1 Mitogen-activated protein kinase kinase 1 interacting PAS_8 PF13188.7 EPA06345.1 - 0.034 14.2 0.0 0.094 12.8 0.0 1.7 1 0 0 1 1 1 0 PAS domain HATPase_c_2 PF13581.6 EPA06345.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain DuffyBP_N PF12377.8 EPA06345.1 - 0.15 12.4 0.0 0.4 11.1 0.0 1.7 1 0 0 1 1 1 0 Duffy binding protein N terminal Big_1 PF02369.16 EPA06346.1 - 1.1e-05 25.3 12.3 5.8e-05 23.0 0.3 4.9 5 0 0 5 5 5 2 Bacterial Ig-like domain (group 1) Invasin_D3 PF09134.10 EPA06346.1 - 0.00015 22.0 14.8 0.084 13.2 1.4 4.8 5 1 0 5 5 5 3 Invasin, domain 3 Synapsin PF02078.16 EPA06347.1 - 0.14 12.5 0.1 1.4 9.3 0.1 2.1 2 0 0 2 2 2 0 Synapsin, N-terminal domain TPR_1 PF00515.28 EPA06348.1 - 7.5e-48 158.5 28.6 5.9e-08 32.2 1.3 12.7 13 0 0 13 13 12 9 Tetratricopeptide repeat TPR_2 PF07719.17 EPA06348.1 - 2e-47 155.5 11.2 7.4e-05 22.6 0.4 14.2 15 0 0 15 15 14 8 Tetratricopeptide repeat TPR_19 PF14559.6 EPA06348.1 - 1.2e-37 128.3 0.7 4.5e-06 27.1 0.0 9.0 5 3 5 10 10 10 7 Tetratricopeptide repeat TPR_8 PF13181.6 EPA06348.1 - 6.4e-33 110.2 36.8 0.00027 20.9 0.0 14.7 15 0 0 15 15 15 8 Tetratricopeptide repeat TPR_16 PF13432.6 EPA06348.1 - 3.1e-31 107.7 0.0 4.9e-07 30.3 0.0 7.1 6 1 0 7 7 7 6 Tetratricopeptide repeat TPR_14 PF13428.6 EPA06348.1 - 4e-30 101.9 0.0 0.12 13.2 0.0 12.1 5 4 8 13 13 13 6 Tetratricopeptide repeat TPR_11 PF13414.6 EPA06348.1 - 4.1e-28 96.8 19.0 0.00027 20.6 0.0 11.1 7 3 5 12 12 11 8 TPR repeat TPR_6 PF13174.6 EPA06348.1 - 8.7e-25 85.7 0.2 0.77 10.5 0.0 12.9 13 1 0 13 13 13 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EPA06348.1 - 1.4e-24 86.1 20.9 3.5e-07 30.4 0.0 6.8 2 2 8 10 10 10 9 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EPA06348.1 - 5.6e-23 79.2 5.0 0.056 13.5 0.0 10.3 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_17 PF13431.6 EPA06348.1 - 6.5e-23 79.4 18.6 0.0076 16.6 0.6 11.0 12 0 0 12 12 10 6 Tetratricopeptide repeat TPR_12 PF13424.6 EPA06348.1 - 1.7e-19 69.8 12.3 0.00085 19.6 0.0 9.8 4 3 3 9 9 9 4 Tetratricopeptide repeat TPR_9 PF13371.6 EPA06348.1 - 1.4e-15 57.2 0.0 0.039 14.1 0.0 6.5 2 1 6 8 8 8 5 Tetratricopeptide repeat TPR_10 PF13374.6 EPA06348.1 - 5.5e-11 42.0 0.1 1.2 9.1 0.0 8.7 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_20 PF14561.6 EPA06348.1 - 1.4e-09 38.1 3.0 0.33 11.3 0.0 7.0 5 2 4 9 9 9 2 Tetratricopeptide repeat NARP1 PF12569.8 EPA06348.1 - 2.8e-07 29.9 20.7 0.013 14.5 1.3 6.8 2 2 4 6 6 6 3 NMDA receptor-regulated protein 1 Fis1_TPR_C PF14853.6 EPA06348.1 - 1.3e-06 28.4 17.7 0.99 9.5 0.1 8.2 8 2 2 10 10 9 3 Fis1 C-terminal tetratricopeptide repeat Coatomer_E PF04733.14 EPA06348.1 - 1.1e-05 25.0 13.1 0.18 11.2 1.7 4.5 3 1 1 4 4 4 3 Coatomer epsilon subunit HrpB1_HrpK PF09613.10 EPA06348.1 - 1.9e-05 24.3 0.0 1.5 8.5 0.0 5.2 2 1 3 5 5 5 1 Bacterial type III secretion protein (HrpB1_HrpK) Rapsyn_N PF10579.9 EPA06348.1 - 4.7e-05 23.4 0.0 18 5.5 0.0 5.8 6 0 0 6 6 6 0 Rapsyn N-terminal myristoylation and linker region DUF5588 PF17826.1 EPA06348.1 - 9.3e-05 21.5 3.9 0.012 14.6 0.3 3.6 3 1 1 4 4 4 1 Family of unknown function (DUF5588) TOM20_plant PF06552.12 EPA06348.1 - 0.00057 19.7 2.4 2.1 8.1 0.1 4.3 3 1 1 4 4 4 1 Plant specific mitochondrial import receptor subunit TOM20 BTAD PF03704.17 EPA06348.1 - 0.0024 18.3 0.0 1.8 9.0 0.0 4.2 3 3 4 7 7 7 1 Bacterial transcriptional activator domain ChAPs PF09295.10 EPA06348.1 - 0.0029 16.7 9.9 0.11 11.4 0.6 3.8 1 1 1 4 4 4 2 ChAPs (Chs5p-Arf1p-binding proteins) DUF4919 PF16266.5 EPA06348.1 - 0.0041 17.1 7.2 0.67 9.9 0.6 4.4 3 2 2 5 5 5 1 Domain of unknown function (DUF4919) PknG_TPR PF16918.5 EPA06348.1 - 0.16 10.7 0.0 5.8 5.5 0.0 3.0 2 2 1 3 3 3 0 Protein kinase G tetratricopeptide repeat MIT PF04212.18 EPA06348.1 - 1.1 9.3 14.9 2.6 8.2 0.1 6.6 6 1 1 7 7 7 0 MIT (microtubule interacting and transport) domain DUF5099 PF17025.5 EPA06348.1 - 7.8 7.0 10.1 2 8.9 0.3 3.8 4 1 0 4 4 3 0 Domain of unknown function (DUF5099) Arch_flagellin PF01917.16 EPA06349.1 - 4e-24 85.6 11.8 6.6e-24 84.9 11.8 1.3 1 1 0 1 1 1 1 Archaebacterial flagellin Glutaminase PF04960.15 EPA06349.1 - 0.042 13.0 1.6 0.054 12.7 1.2 1.4 1 1 0 1 1 1 0 Glutaminase DUF4148 PF13663.6 EPA06349.1 - 0.32 11.2 2.9 19 5.6 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) Pilin_N PF07790.11 EPA06349.1 - 3.5 8.6 10.5 8.2 7.4 7.3 2.6 1 1 2 3 3 3 0 Archaeal Type IV pilin, N-terminal DUF4106 PF13388.6 EPA06350.1 - 0.081 12.1 4.5 0.11 11.7 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) CT47 PF15623.6 EPA06350.1 - 1.1 9.0 8.8 1.5 8.6 8.8 1.1 1 0 0 1 1 1 0 Cancer/testis gene family 47 Nucleo_P87 PF07267.11 EPA06350.1 - 1.3 7.8 3.7 1.7 7.4 3.7 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Cu-oxidase_3 PF07732.15 EPA06352.1 - 6.5e-11 42.3 2.2 1.7e-09 37.7 0.5 2.5 2 0 0 2 2 2 2 Multicopper oxidase DUF4420 PF14390.6 EPA06352.1 - 0.13 11.5 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Putative PD-(D/E)XK family member, (DUF4420) DUF5612 PF18462.1 EPA06353.1 - 0.14 12.0 0.0 0.38 10.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5612) Tubulin PF00091.25 EPA06355.1 - 4.8e-16 59.5 2.7 1.2e-14 54.9 0.1 2.6 2 1 1 3 3 3 2 Tubulin/FtsZ family, GTPase domain PS_Dcarbxylase PF02666.15 EPA06355.1 - 0.053 13.1 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylserine decarboxylase Tubulin_2 PF13809.6 EPA06355.1 - 0.054 12.7 0.2 2.5 7.2 0.0 2.2 1 1 1 2 2 2 0 Tubulin like Lyase_1 PF00206.20 EPA06357.1 - 9.5e-88 294.6 1.4 1.2e-87 294.3 1.4 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EPA06357.1 - 1.3e-13 51.2 0.0 3.3e-13 49.8 0.0 1.8 1 0 0 1 1 1 1 Fumarase C C-terminus Ribosomal_L15e PF00827.17 EPA06358.1 - 1.2e-44 152.3 4.9 1.5e-44 152.0 4.9 1.0 1 0 0 1 1 1 1 Ribosomal L15 Radical_SAM PF04055.21 EPA06359.1 - 3.3e-20 73.1 0.1 4.7e-20 72.6 0.1 1.2 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.20 EPA06359.1 - 2e-15 56.6 0.1 2e-15 56.6 0.1 1.8 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 TRAM_2 PF18693.1 EPA06359.1 - 0.0092 16.1 0.2 0.05 13.8 0.2 2.3 1 1 0 1 1 1 1 TRAM domain zf-PARP PF00645.18 EPA06359.1 - 0.032 15.1 0.3 0.12 13.2 0.3 2.0 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region TRAM PF01938.20 EPA06359.1 - 0.053 13.5 0.1 0.2 11.6 0.1 2.1 1 0 0 1 1 1 0 TRAM domain 2-Hacid_dh_C PF02826.19 EPA06360.1 - 1.3e-63 213.6 0.4 2.2e-63 212.8 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EPA06360.1 - 1.2e-29 102.7 0.2 1.3e-29 102.6 0.2 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EPA06360.1 - 0.0031 17.7 0.7 0.01 16.0 0.0 2.0 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase LXG PF04740.12 EPA06360.1 - 0.024 14.4 0.0 0.042 13.5 0.0 1.4 1 0 0 1 1 1 0 LXG domain of WXG superfamily MG2 PF01835.19 EPA06364.1 - 4.6e-06 27.0 0.0 0.00013 22.3 0.0 2.6 2 0 0 2 2 2 1 MG2 domain YtkA PF13115.6 EPA06364.1 - 0.0023 18.5 0.0 3.4 8.3 0.1 2.7 2 0 0 2 2 2 2 YtkA-like DUF812 PF05667.11 EPA06364.1 - 0.0072 15.3 8.1 0.009 14.9 8.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Filamin PF00630.19 EPA06364.1 - 0.013 16.3 1.5 0.25 12.2 0.0 2.6 1 1 0 2 2 2 0 Filamin/ABP280 repeat DUF3450 PF11932.8 EPA06364.1 - 0.034 13.5 5.8 0.06 12.6 5.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 EPA06364.1 - 0.053 12.4 14.7 0.11 11.4 14.7 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3437 PF11919.8 EPA06364.1 - 0.059 13.3 0.4 0.16 11.9 0.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) Golgin_A5 PF09787.9 EPA06364.1 - 0.062 12.8 8.3 0.11 11.9 8.3 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 KELK PF15796.5 EPA06364.1 - 0.15 12.5 11.6 0.35 11.3 11.6 1.6 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase LMBR1 PF04791.16 EPA06364.1 - 0.15 10.9 3.4 0.24 10.2 3.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Mod_r PF07200.13 EPA06364.1 - 0.25 11.4 13.1 0.019 15.1 7.8 1.8 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein CALCOCO1 PF07888.11 EPA06364.1 - 0.26 10.1 9.8 0.51 9.2 9.8 1.4 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Atg14 PF10186.9 EPA06364.1 - 0.67 9.0 11.2 1.1 8.3 11.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4140 PF13600.6 EPA06364.1 - 4 7.9 6.4 0.4 11.2 1.2 2.1 2 0 0 2 2 1 0 N-terminal domain of unknown function (DUF4140) APG6_N PF17675.1 EPA06364.1 - 7.8 7.0 14.6 24 5.5 14.6 1.8 1 0 0 1 1 1 0 Apg6 coiled-coil region TMPIT PF07851.13 EPA06364.1 - 7.9 5.6 11.1 13 4.9 11.1 1.3 1 0 0 1 1 1 0 TMPIT-like protein DivIC PF04977.15 EPA06364.1 - 9.3 6.1 13.9 0.54 10.1 5.4 2.5 1 1 1 2 2 2 0 Septum formation initiator ZapB PF06005.12 EPA06364.1 - 9.9 6.7 14.5 24 5.5 9.3 2.6 1 1 1 2 2 2 0 Cell division protein ZapB NRDD PF13597.6 EPA06365.1 - 2.7e-27 95.8 0.0 4.9e-20 71.8 0.0 2.3 2 0 0 2 2 2 2 Anaerobic ribonucleoside-triphosphate reductase HTH_20 PF12840.7 EPA06365.1 - 4.4e-10 39.5 0.0 1.2e-09 38.0 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain ATP-cone PF03477.16 EPA06365.1 - 1.4e-06 28.7 1.8 1.2e-05 25.8 0.0 3.4 3 2 2 5 5 5 1 ATP cone domain Lig_C PF18330.1 EPA06365.1 - 0.0066 16.4 0.9 0.65 10.0 0.0 3.3 3 0 0 3 3 3 1 Ligase Pab1020 C-terminal region TackOD1 PF18551.1 EPA06365.1 - 0.085 12.5 1.8 0.094 12.4 0.2 1.9 2 0 0 2 2 2 0 Thaumarchaeal output domain 1 Histidinol_dh PF00815.20 EPA06366.1 - 0.0026 16.8 0.0 0.0027 16.8 0.0 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase HisG PF01634.18 EPA06367.1 - 8.1e-44 149.4 0.0 1.1e-43 149.0 0.0 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 EPA06367.1 - 6.6e-15 55.0 0.0 1.6e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 HisG, C-terminal domain Histidinol_dh PF00815.20 EPA06368.1 - 1.3e-126 423.0 0.0 1.6e-126 422.6 0.0 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase ssDNA_DBD PF18333.1 EPA06368.1 - 0.016 15.3 0.1 0.034 14.2 0.1 1.5 1 0 0 1 1 1 0 Non-canonical single-stranded DNA-binding domain Tubulin_C PF03953.17 EPA06368.1 - 0.078 13.2 0.0 0.23 11.6 0.0 1.8 1 0 0 1 1 1 0 Tubulin C-terminal domain DUF643 PF04867.12 EPA06368.1 - 4.3 8.0 10.6 0.082 13.5 1.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF643) CBM32 PF18344.1 EPA06370.1 - 0.093 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate binding module family 32 Aminotran_1_2 PF00155.21 EPA06371.1 - 2.2e-38 132.4 0.0 2.5e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 EPA06371.1 - 1.3e-05 24.3 0.0 1.6e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Allinase Aminotran_5 PF00266.19 EPA06371.1 - 0.029 13.3 0.0 0.097 11.6 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class-V LTD PF00932.19 EPA06372.1 - 8.1e-17 61.6 4.0 5.5e-16 58.9 0.7 2.8 3 0 0 3 3 3 1 Lamin Tail Domain MG2 PF01835.19 EPA06372.1 - 6.3e-08 33.0 0.2 0.0014 19.0 0.0 4.4 5 1 0 5 5 5 2 MG2 domain Big_8 PF17961.1 EPA06372.1 - 0.26 11.4 4.7 0.55 10.4 0.1 3.1 3 0 0 3 3 3 0 Bacterial Ig domain HMG-CoA_red PF00368.18 EPA06374.1 - 6.2e-64 216.3 3.6 7.4e-64 216.0 3.6 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase GatB_Yqey PF02637.18 EPA06374.1 - 0.057 13.3 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 GatB domain AsnC_trans_reg PF01037.21 EPA06376.1 - 5.4e-10 39.1 0.1 5.7e-10 39.0 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain Zn_ribbon_SprT PF17283.2 EPA06378.1 - 3.5e-05 23.6 8.6 0.035 14.0 0.7 2.3 2 0 0 2 2 2 2 SprT-like zinc ribbon domain Molybdop_Fe4S4 PF04879.16 EPA06378.1 - 0.0019 18.1 6.9 0.23 11.5 0.5 2.3 2 0 0 2 2 2 2 Molybdopterin oxidoreductase Fe4S4 domain DNA_RNApol_7kD PF03604.13 EPA06378.1 - 0.0087 15.7 15.8 0.44 10.3 4.0 2.7 2 0 0 2 2 2 2 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_6 PF14599.6 EPA06378.1 - 0.031 14.3 10.8 0.45 10.6 1.7 2.9 2 2 1 3 3 3 0 Zinc-ribbon DUF866 PF05907.13 EPA06378.1 - 0.18 11.7 0.8 11 5.9 0.1 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF866) DUF1059 PF06348.11 EPA06378.1 - 0.76 10.1 4.5 15 5.9 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1059) LIM PF00412.22 EPA06378.1 - 3 8.1 12.8 7.3 6.9 2.5 2.3 2 0 0 2 2 2 0 LIM domain SCIFF PF13165.6 EPA06378.1 - 4.2 7.4 10.8 7.6 6.6 0.3 3.3 4 0 0 4 4 4 0 Six-cysteine peptide SCIFF Elf1 PF05129.13 EPA06378.1 - 6.5 6.9 11.1 3.8 7.6 0.1 3.0 2 2 1 3 3 3 0 Transcription elongation factor Elf1 like TRAM1 PF08390.11 EPA06380.1 - 0.056 13.1 0.7 0.1 12.3 0.7 1.4 1 0 0 1 1 1 0 TRAM1-like protein ADH_zinc_N PF00107.26 EPA06381.1 - 1.1e-05 25.4 0.1 1.4e-05 25.1 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EPA06381.1 - 0.00052 21.1 0.0 0.00053 21.1 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CoA_binding PF02629.19 EPA06381.1 - 0.0026 18.4 1.5 0.045 14.4 0.1 2.1 1 1 1 2 2 2 1 CoA binding domain DUF4443 PF14544.6 EPA06381.1 - 0.012 15.8 0.1 0.014 15.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4443) TssC PF17541.2 EPA06381.1 - 0.074 11.9 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB TruD PF01142.18 EPA06384.1 - 6.7e-15 54.8 0.0 7.1e-15 54.7 0.0 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) AAA_33 PF13671.6 EPA06386.1 - 8e-15 55.3 0.0 9.5e-15 55.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EPA06386.1 - 9e-05 23.0 0.0 0.00014 22.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF3791 PF12668.7 EPA06386.1 - 0.00034 20.6 0.3 0.0011 19.0 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3791) UDPG_MGDP_dh PF00984.19 EPA06386.1 - 0.0029 17.8 0.0 0.25 11.6 0.0 2.1 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain AAA_17 PF13207.6 EPA06386.1 - 0.0034 17.8 0.1 0.0056 17.1 0.1 1.4 1 1 0 1 1 1 1 AAA domain ARL2_Bind_BART PF11527.8 EPA06386.1 - 0.017 15.2 0.8 0.03 14.4 0.2 1.6 2 0 0 2 2 2 0 The ARF-like 2 binding protein BART DUF5621 PF18532.1 EPA06386.1 - 0.055 13.4 0.6 0.14 12.0 0.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5621) SRP54 PF00448.22 EPA06386.1 - 0.16 11.6 0.6 1.5 8.4 0.5 2.1 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ATP_bind_1 PF03029.17 EPA06386.1 - 0.2 11.4 0.7 0.5 10.1 0.2 1.8 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Lar_restr_allev PF14354.6 EPA06387.1 - 0.00019 21.7 3.2 0.00022 21.5 1.4 2.0 2 0 0 2 2 2 1 Restriction alleviation protein Lar zinc_ribbon_5 PF13719.6 EPA06387.1 - 0.0077 16.0 1.5 0.016 14.9 1.5 1.5 1 0 0 1 1 1 1 zinc-ribbon domain Tmemb_55A PF09788.9 EPA06387.1 - 0.026 13.6 5.2 0.026 13.6 4.5 1.3 1 1 0 1 1 1 0 Transmembrane protein 55A Elf1 PF05129.13 EPA06387.1 - 0.048 13.7 1.7 0.048 13.7 1.7 1.8 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like OrfB_Zn_ribbon PF07282.11 EPA06387.1 - 0.056 13.4 2.2 0.14 12.1 2.2 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-RING_7 PF02591.15 EPA06387.1 - 0.069 13.3 2.3 3.6 7.8 0.1 2.4 2 0 0 2 2 2 0 C4-type zinc ribbon domain TF_Zn_Ribbon PF08271.12 EPA06387.1 - 0.083 12.4 5.3 0.2 11.2 5.3 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding ADD_ATRX PF17981.1 EPA06387.1 - 0.42 10.5 3.1 5.5 6.9 0.1 2.3 1 1 1 2 2 2 0 Cysteine Rich ADD domain Prok-RING_1 PF14446.6 EPA06387.1 - 0.97 9.4 6.2 0.57 10.1 2.9 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 DNA_RNApol_7kD PF03604.13 EPA06387.1 - 1.2 8.8 10.1 1.4 8.7 7.0 2.5 2 1 1 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit DUF2196 PF09962.9 EPA06389.1 - 8.9e-29 99.3 1.3 9.4e-29 99.2 1.3 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2196) ADH_N PF08240.12 EPA06390.1 - 8.5e-24 83.5 0.1 1.4e-23 82.8 0.1 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EPA06390.1 - 6.2e-07 29.4 0.2 1.2e-06 28.5 0.2 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EPA06390.1 - 0.00024 20.5 0.3 0.00034 20.0 0.3 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EPA06390.1 - 0.023 14.0 0.2 0.03 13.6 0.2 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MA3 PF02847.17 EPA06390.1 - 0.14 12.2 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 MA3 domain Met_synt_B12 PF02965.17 EPA06391.1 - 1.2e-05 25.0 0.1 1.2e-05 24.9 0.1 1.0 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain MTHFR PF02219.17 EPA06392.1 - 2.2e-07 30.5 0.1 0.005 16.2 0.0 2.1 2 0 0 2 2 2 2 Methylenetetrahydrofolate reductase Beta_protein PF14350.6 EPA06392.1 - 0.14 11.6 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Beta protein WhiA_N PF10298.9 EPA06394.1 - 0.0098 15.9 0.2 0.67 10.0 0.0 3.0 3 0 0 3 3 3 2 WhiA N-terminal LAGLIDADG-like domain Rpr2 PF04032.16 EPA06395.1 - 0.0062 16.8 0.6 0.01 16.1 0.1 1.5 1 1 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain TF_Zn_Ribbon PF08271.12 EPA06395.1 - 0.01 15.3 0.1 0.3 10.6 0.0 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding Lar_restr_allev PF14354.6 EPA06395.1 - 0.017 15.5 0.1 0.023 15.1 0.1 1.3 1 0 0 1 1 1 0 Restriction alleviation protein Lar Ribosomal_L32p PF01783.23 EPA06395.1 - 0.034 14.4 0.4 0.22 11.8 0.0 2.2 2 0 0 2 2 2 0 Ribosomal L32p protein family Vps36-NZF-N PF16988.5 EPA06395.1 - 0.084 12.3 0.2 0.28 10.6 0.0 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain OrfB_Zn_ribbon PF07282.11 EPA06395.1 - 0.086 12.8 0.5 3.3 7.7 0.0 2.2 2 0 0 2 2 2 0 Putative transposase DNA-binding domain PUA_2 PF14306.6 EPA06396.1 - 3.2e-09 36.7 0.0 7e-09 35.5 0.0 1.5 1 1 0 1 1 1 1 PUA-like domain PAPS_reduct PF01507.19 EPA06397.1 - 1.6e-43 148.8 0.0 2e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family YtxH PF12732.7 EPA06398.1 - 0.012 16.2 0.5 0.012 16.1 0.5 1.1 1 0 0 1 1 1 0 YtxH-like protein PUA_2 PF14306.6 EPA06399.1 - 7.5e-27 94.0 0.1 8.4e-27 93.8 0.1 1.0 1 0 0 1 1 1 1 PUA-like domain Npa1 PF11707.8 EPA06399.1 - 0.12 11.7 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Ribosome 60S biogenesis N-terminal GATase PF00117.28 EPA06400.1 - 2.2e-19 70.0 0.0 2.6e-19 69.7 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EPA06400.1 - 9.7e-09 35.3 0.0 3e-07 30.4 0.0 2.1 1 1 0 1 1 1 1 Peptidase C26 SNO PF01174.19 EPA06400.1 - 0.0064 16.4 0.0 0.39 10.5 0.0 2.2 2 0 0 2 2 2 2 SNO glutamine amidotransferase family TPR_1 PF00515.28 EPA06401.1 - 8.2e-15 53.9 17.0 2.4e-08 33.5 1.4 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 EPA06401.1 - 2e-12 46.2 11.6 1.7e-06 27.7 0.5 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EPA06401.1 - 1.3e-11 44.0 13.6 0.00032 20.9 1.4 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EPA06401.1 - 2.1e-08 33.7 20.3 2.4e-05 24.2 0.9 5.1 5 1 0 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EPA06401.1 - 4e-07 29.6 13.6 0.00013 21.6 0.2 3.9 3 1 1 4 4 3 3 TPR repeat TPR_12 PF13424.6 EPA06401.1 - 1.3e-06 28.6 0.9 0.0013 19.0 0.1 3.4 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EPA06401.1 - 2.3e-06 27.9 0.0 0.45 11.5 0.0 4.0 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EPA06401.1 - 2.4e-06 27.9 2.4 0.024 15.1 0.1 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EPA06401.1 - 8.5e-05 23.1 0.0 3.2 8.5 0.0 3.1 2 1 2 4 4 4 3 Tetratricopeptide repeat Peptidase_C39_2 PF13529.6 EPA06401.1 - 0.00012 22.7 0.0 0.00036 21.1 0.0 1.8 1 0 0 1 1 1 1 Peptidase_C39 like family TPR_6 PF13174.6 EPA06401.1 - 0.00014 22.3 3.4 0.37 11.5 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat Peptidase_C39 PF03412.15 EPA06401.1 - 0.00031 20.5 0.0 0.0097 15.7 0.0 2.5 2 2 0 2 2 2 1 Peptidase C39 family TPR_9 PF13371.6 EPA06401.1 - 0.0066 16.6 0.0 0.024 14.8 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EPA06401.1 - 0.071 13.2 1.1 10 6.4 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Peptidase_C70 PF12385.8 EPA06401.1 - 0.11 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Papain-like cysteine protease AvrRpt2 UPF0182 PF03699.13 EPA06402.1 - 3e-36 124.9 6.4 3.8e-35 121.3 6.4 2.3 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0182) DUF2897 PF11446.8 EPA06402.1 - 1.4 8.9 2.9 3.2 7.7 2.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) GSDH PF07995.11 EPA06403.1 - 2.3e-09 37.0 0.0 2.3e-09 37.0 0.0 1.0 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase HMG-CoA_red PF00368.18 EPA06404.1 - 1e-24 87.3 0.0 1.1e-24 87.1 0.0 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase GSDH PF07995.11 EPA06405.1 - 5e-53 180.5 0.0 6.1e-53 180.3 0.0 1.0 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase tRNA_anti_2 PF13742.6 EPA06406.1 - 0.084 13.1 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Diphthami_syn_2 PF01902.17 EPA06407.1 - 1e-56 191.9 0.1 1.2e-56 191.7 0.1 1.0 1 0 0 1 1 1 1 Diphthamide synthase QueC PF06508.13 EPA06407.1 - 0.021 14.3 0.0 0.071 12.6 0.0 1.9 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EPA06407.1 - 0.1 11.4 0.0 0.25 10.1 0.0 1.6 2 0 0 2 2 2 0 tRNA methyl transferase DAP3 PF10236.9 EPA06408.1 - 0.049 12.8 0.0 0.054 12.7 0.0 1.0 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 SRP54 PF00448.22 EPA06409.1 - 3.8e-31 108.2 0.3 1.1e-30 106.8 0.0 1.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 EPA06409.1 - 1.2e-17 63.8 1.6 2e-17 63.2 1.6 1.3 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain CbiA PF01656.23 EPA06409.1 - 1.1e-05 25.5 0.1 2.4e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 EPA06409.1 - 3e-05 23.6 0.5 4.9e-05 22.9 0.3 1.5 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase MobB PF03205.14 EPA06409.1 - 0.00017 21.5 0.3 0.00041 20.3 0.3 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B APS_kinase PF01583.20 EPA06409.1 - 0.00035 20.5 0.7 0.00089 19.2 0.1 1.9 2 0 0 2 2 2 1 Adenylylsulphate kinase 6PF2K PF01591.18 EPA06409.1 - 0.00038 19.8 0.0 0.00072 18.9 0.0 1.4 1 0 0 1 1 1 1 6-phosphofructo-2-kinase MeaB PF03308.16 EPA06409.1 - 0.00056 19.0 0.1 0.0021 17.1 0.0 1.9 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB KTI12 PF08433.10 EPA06409.1 - 0.00057 19.4 0.4 0.0011 18.5 0.0 1.6 2 0 0 2 2 2 1 Chromatin associated protein KTI12 Arf PF00025.21 EPA06409.1 - 0.0018 17.7 0.1 0.004 16.6 0.1 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Zeta_toxin PF06414.12 EPA06409.1 - 0.0021 17.4 0.0 0.0031 16.8 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Thymidylate_kin PF02223.17 EPA06409.1 - 0.0035 17.0 0.8 0.0082 15.8 0.4 1.7 2 0 0 2 2 2 1 Thymidylate kinase AAA_33 PF13671.6 EPA06409.1 - 0.0037 17.4 0.0 0.0071 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EPA06409.1 - 0.0039 17.5 0.1 0.018 15.3 0.0 2.0 2 1 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 EPA06409.1 - 0.0056 16.5 0.1 0.011 15.5 0.1 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein LpxK PF02606.14 EPA06409.1 - 0.0062 15.7 0.1 0.0094 15.1 0.1 1.3 1 0 0 1 1 1 1 Tetraacyldisaccharide-1-P 4'-kinase AAA_7 PF12775.7 EPA06409.1 - 0.0063 16.1 0.1 0.0098 15.4 0.1 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 EPA06409.1 - 0.0065 17.0 0.3 0.016 15.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 EPA06409.1 - 0.0099 15.1 0.3 0.017 14.3 0.1 1.5 1 1 0 1 1 1 1 G-protein alpha subunit AAA_30 PF13604.6 EPA06409.1 - 0.011 15.5 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EPA06409.1 - 0.011 15.7 0.3 0.011 15.7 0.3 2.0 3 0 0 3 3 2 0 NTPase AAA_31 PF13614.6 EPA06409.1 - 0.012 15.6 0.4 0.012 15.6 0.4 2.3 2 1 1 3 3 3 0 AAA domain MipZ PF09140.11 EPA06409.1 - 0.012 15.0 0.6 0.68 9.2 0.2 2.2 1 1 1 2 2 2 0 ATPase MipZ ResIII PF04851.15 EPA06409.1 - 0.015 15.3 1.7 0.057 13.4 0.6 1.9 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit cobW PF02492.19 EPA06409.1 - 0.025 14.2 0.3 0.064 12.8 0.3 1.8 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EPA06409.1 - 0.031 14.8 0.2 0.058 13.9 0.0 1.6 2 0 0 2 2 1 0 ABC transporter SRPRB PF09439.10 EPA06409.1 - 0.037 13.5 0.1 0.086 12.3 0.1 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_5 PF07728.14 EPA06409.1 - 0.042 13.8 0.2 0.081 12.9 0.2 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SpoVIF PF14069.6 EPA06409.1 - 0.043 13.6 2.4 0.11 12.3 1.6 2.1 1 1 1 2 2 2 0 Stage VI sporulation protein F AAA_28 PF13521.6 EPA06409.1 - 0.054 13.7 0.2 0.092 13.0 0.2 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EPA06409.1 - 0.063 13.7 0.4 0.17 12.2 0.1 1.8 1 1 1 2 2 2 0 AAA ATPase domain IstB_IS21 PF01695.17 EPA06409.1 - 0.09 12.5 0.0 0.22 11.2 0.0 1.6 2 0 0 2 2 1 0 IstB-like ATP binding protein DLP_helical PF18709.1 EPA06409.1 - 0.092 11.9 1.5 0.1 11.8 0.4 1.6 2 0 0 2 2 2 0 Dynamin-like helical domain AAA_24 PF13479.6 EPA06409.1 - 0.1 12.3 0.5 0.2 11.4 0.5 1.6 1 1 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 EPA06409.1 - 0.14 11.0 0.1 0.23 10.4 0.1 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_17 PF13207.6 EPA06409.1 - 0.15 12.4 3.5 0.16 12.4 0.6 2.2 2 1 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EPA06409.1 - 0.16 11.7 1.1 0.3 10.8 0.3 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ArsA_ATPase PF02374.15 EPA06409.1 - 0.19 10.8 2.1 0.6 9.2 0.5 2.3 3 0 0 3 3 3 0 Anion-transporting ATPase Big_9 PF17963.1 EPA06410.1 - 6.4e-14 52.5 5.1 6.4e-14 52.5 5.1 2.1 2 0 0 2 2 2 1 Bacterial Ig domain Cadherin_5 PF17892.1 EPA06410.1 - 3.9e-12 46.0 3.6 8.4e-12 44.9 3.6 1.5 1 0 0 1 1 1 1 Cadherin-like domain Cadherin_4 PF17803.1 EPA06410.1 - 7.8e-07 29.6 2.2 7.8e-07 29.6 2.2 2.2 2 0 0 2 2 2 1 Bacterial cadherin-like domain DUF4398 PF14346.6 EPA06410.1 - 0.00024 21.7 9.5 0.0004 20.9 9.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4398) PilJ PF13675.6 EPA06410.1 - 0.051 13.6 4.6 0.48 10.5 1.8 2.3 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Big_11 PF18200.1 EPA06410.1 - 0.087 12.8 0.1 3.7 7.5 0.0 2.4 2 0 0 2 2 2 0 Bacterial Ig-like domain KIP1 PF07765.12 EPA06410.1 - 0.096 12.8 5.2 0.36 11.0 1.0 2.9 2 0 0 2 2 2 0 KIP1-like protein TPR_1 PF00515.28 EPA06410.1 - 0.15 12.0 0.5 4.7 7.2 0.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat RPAP3_C PF13877.6 EPA06410.1 - 0.16 12.5 2.3 0.23 12.0 0.6 2.0 2 0 0 2 2 2 0 Potential Monad-binding region of RPAP3 DUF1771 PF08590.10 EPA06410.1 - 0.19 12.1 5.5 0.26 11.7 5.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1771) DUF445 PF04286.12 EPA06410.1 - 0.55 10.0 9.0 0.77 9.5 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) TPR_2 PF07719.17 EPA06410.1 - 0.89 9.8 3.5 32 5.0 0.2 3.8 2 1 2 4 4 4 0 Tetratricopeptide repeat Cytochrom_B562 PF07361.11 EPA06410.1 - 1.4 9.6 14.2 0.5 11.1 4.2 3.2 1 1 2 3 3 3 0 Cytochrome b562 GvpG PF05120.12 EPA06410.1 - 1.7 8.7 6.6 7.2 6.7 1.9 3.1 2 1 1 3 3 3 0 Gas vesicle protein G DUF2524 PF10732.9 EPA06410.1 - 3.2 8.1 7.6 25 5.3 3.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2524) CorA PF01544.18 EPA06410.1 - 6.7 5.9 8.6 22 4.2 8.4 1.8 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein SHOCT PF09851.9 EPA06411.1 - 1.1e-07 31.4 0.6 1.3e-07 31.2 0.6 1.1 1 0 0 1 1 1 1 Short C-terminal domain Zn-ribbon_8 PF09723.10 EPA06413.1 - 0.0014 18.7 0.4 0.0018 18.3 0.4 1.3 1 0 0 1 1 1 1 Zinc ribbon domain Tnp_zf-ribbon_2 PF13842.6 EPA06413.1 - 0.0018 19.0 4.0 0.0022 18.7 4.0 1.2 1 0 0 1 1 1 1 DDE_Tnp_1-like zinc-ribbon ADK_lid PF05191.14 EPA06413.1 - 0.0072 16.3 1.0 0.0093 15.9 1.0 1.2 1 0 0 1 1 1 1 Adenylate kinase, active site lid DUF4379 PF14311.6 EPA06413.1 - 0.013 15.9 1.0 0.025 14.9 1.0 1.4 1 0 0 1 1 1 0 Probable Zinc-ribbon domain zf-C2HC5 PF06221.13 EPA06413.1 - 0.016 15.2 0.9 0.016 15.2 0.9 1.1 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type zf-RING_7 PF02591.15 EPA06413.1 - 0.019 15.1 0.4 4.1 7.7 0.0 2.2 2 0 0 2 2 2 0 C4-type zinc ribbon domain Rubredoxin_2 PF18073.1 EPA06413.1 - 0.021 14.6 6.2 1.1 9.0 1.5 2.1 2 0 0 2 2 2 0 Rubredoxin metal binding domain Tmemb_55A PF09788.9 EPA06413.1 - 0.021 13.9 0.7 0.023 13.8 0.7 1.0 1 0 0 1 1 1 0 Transmembrane protein 55A PhnA_Zn_Ribbon PF08274.12 EPA06413.1 - 0.032 14.2 1.0 3.8 7.5 0.1 2.2 2 0 0 2 2 2 0 PhnA Zinc-Ribbon Ribosomal_L32p PF01783.23 EPA06413.1 - 0.065 13.5 2.8 1.1 9.6 0.3 2.0 1 1 1 2 2 2 0 Ribosomal L32p protein family RecR PF02132.15 EPA06413.1 - 0.077 12.6 3.9 2.9 7.5 4.5 2.0 1 1 1 2 2 2 0 RecR protein zf-ribbon_3 PF13248.6 EPA06413.1 - 0.088 12.2 3.3 2.3 7.8 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 EPA06413.1 - 0.11 12.0 3.9 0.21 11.1 0.2 2.1 1 1 1 2 2 2 0 TFIIB zinc-binding zf-trcl PF13451.6 EPA06413.1 - 0.14 12.0 4.4 0.21 11.5 0.3 2.0 1 1 1 2 2 2 0 Probable zinc-ribbon domain zf-C2H2 PF00096.26 EPA06414.1 - 3.5e-06 27.2 7.7 0.00061 20.1 0.5 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 EPA06414.1 - 2.9e-05 23.7 3.3 0.075 12.8 0.5 2.2 1 1 1 2 2 2 2 zinc-finger C2H2-type zf-C2H2_4 PF13894.6 EPA06414.1 - 3e-05 24.5 10.2 0.017 15.9 0.6 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zinc_ribbon_4 PF13717.6 EPA06414.1 - 0.00048 20.0 4.0 0.03 14.3 0.3 2.4 2 0 0 2 2 2 1 zinc-ribbon domain zf-C2H2_3rep PF18868.1 EPA06414.1 - 0.0012 19.5 2.1 0.23 12.2 0.2 2.0 1 1 1 2 2 2 1 Zinc finger C2H2-type, 3 repeats Zn-ribbon_8 PF09723.10 EPA06414.1 - 0.0025 17.9 5.2 0.0025 17.9 5.2 1.7 1 1 1 2 2 2 2 Zinc ribbon domain RNA_POL_M_15KD PF02150.16 EPA06414.1 - 0.0031 17.3 3.0 0.27 11.2 0.3 2.3 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit zf-trcl PF13451.6 EPA06414.1 - 0.0063 16.4 4.2 0.9 9.5 0.1 2.4 2 1 0 2 2 2 2 Probable zinc-ribbon domain DNA_RNApol_7kD PF03604.13 EPA06414.1 - 0.01 15.5 4.9 0.11 12.2 0.7 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-DNA_Pol PF08996.10 EPA06414.1 - 0.013 15.3 2.9 0.014 15.1 2.9 1.1 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger DUF678 PF05077.12 EPA06414.1 - 0.015 15.4 2.1 0.94 9.7 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF678) CpXC PF14353.6 EPA06414.1 - 0.016 15.3 2.3 0.65 10.1 0.1 2.0 1 1 1 2 2 2 0 CpXC protein XPA_N PF01286.18 EPA06414.1 - 0.016 15.3 5.2 1.8 8.7 0.3 2.4 2 0 0 2 2 2 0 XPA protein N-terminal Prok-RING_1 PF14446.6 EPA06414.1 - 0.016 15.1 3.2 0.42 10.6 0.3 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zinc_ribbon_15 PF17032.5 EPA06414.1 - 0.018 15.8 6.6 0.023 15.4 6.6 1.3 1 1 0 1 1 1 0 zinc-ribbon family DUF35_N PF12172.8 EPA06414.1 - 0.02 14.8 0.9 4.1 7.4 0.1 2.2 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Ephrin_rec_like PF07699.13 EPA06414.1 - 0.03 14.1 4.1 1.5 8.6 0.1 2.1 1 1 1 2 2 2 0 Putative ephrin-receptor like FYVE PF01363.21 EPA06414.1 - 0.035 14.2 10.2 0.27 11.4 3.7 2.0 1 1 1 2 2 2 0 FYVE zinc finger zf-C2H2_2 PF12756.7 EPA06414.1 - 0.041 14.2 7.5 1.8 8.9 2.8 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) PhnA_Zn_Ribbon PF08274.12 EPA06414.1 - 0.045 13.7 2.1 2.1 8.4 0.1 2.3 2 0 0 2 2 2 0 PhnA Zinc-Ribbon ADK_lid PF05191.14 EPA06414.1 - 0.053 13.5 3.2 0.054 13.5 1.4 1.8 1 1 1 2 2 2 0 Adenylate kinase, active site lid zf-HYPF PF07503.12 EPA06414.1 - 0.059 13.2 3.7 5 7.0 0.1 2.4 2 0 0 2 2 2 0 HypF finger DZR PF12773.7 EPA06414.1 - 0.062 13.3 6.1 0.093 12.8 6.1 1.4 1 1 0 1 1 1 0 Double zinc ribbon zf-C2H2_6 PF13912.6 EPA06414.1 - 0.072 13.1 14.8 0.14 12.1 4.6 2.3 2 1 0 2 2 2 0 C2H2-type zinc finger zf_UBZ PF18439.1 EPA06414.1 - 0.074 12.7 3.4 0.86 9.3 0.2 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger TFIIS_C PF01096.18 EPA06414.1 - 0.082 12.8 3.3 0.73 9.7 0.2 2.4 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) DUF983 PF06170.12 EPA06414.1 - 0.12 12.8 2.3 2.6 8.5 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF983) zf-H2C2_2 PF13465.6 EPA06414.1 - 0.12 12.8 13.6 0.97 10.0 0.9 3.1 3 0 0 3 3 3 0 Zinc-finger double domain HypA PF01155.19 EPA06414.1 - 0.13 12.3 6.7 0.15 12.1 4.0 1.9 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Fibrillin_U_N PF18193.1 EPA06414.1 - 0.19 11.9 1.6 6.8 6.9 0.2 2.3 2 0 0 2 2 2 0 Fibrillin 1 unique N-terminal domain zf-CSL PF05207.13 EPA06414.1 - 0.23 11.2 4.2 5.2 6.9 0.3 2.1 1 1 1 2 2 2 0 CSL zinc finger TF_Zn_Ribbon PF08271.12 EPA06414.1 - 0.25 10.9 5.3 1.5 8.4 0.1 2.5 3 0 0 3 3 3 0 TFIIB zinc-binding Rubredoxin_2 PF18073.1 EPA06414.1 - 0.35 10.6 5.0 3.7 7.3 0.6 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain Zn_ribbon_recom PF13408.6 EPA06414.1 - 0.38 11.3 7.8 3.9 8.1 7.8 2.1 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain zf-C2HC_2 PF13913.6 EPA06414.1 - 1.2 9.1 16.8 3 7.8 7.2 2.6 1 1 1 2 2 2 0 zinc-finger of a C2HC-type zinc_ribbon_5 PF13719.6 EPA06414.1 - 1.4 8.7 10.6 1.8 8.4 7.6 2.2 1 1 2 3 3 3 0 zinc-ribbon domain zf-BED PF02892.15 EPA06414.1 - 4.2 7.5 12.1 2.7 8.1 4.6 2.3 1 1 1 2 2 2 0 BED zinc finger ARS2 PF04959.13 EPA06414.1 - 6.7 7.0 11.8 3.6 7.9 3.2 2.0 1 1 1 2 2 2 0 Arsenite-resistance protein 2 OrfB_Zn_ribbon PF07282.11 EPA06415.1 - 0.0012 18.7 1.2 0.0014 18.5 1.2 1.1 1 0 0 1 1 1 1 Putative transposase DNA-binding domain SAUGI PF06106.11 EPA06415.1 - 0.033 14.7 0.1 0.033 14.7 0.1 1.1 1 0 0 1 1 1 0 S. aureus uracil DNA glycosylase inhibitor Desulfoferrod_N PF06397.12 EPA06415.1 - 0.036 13.7 1.2 0.4 10.3 0.0 2.1 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain Ima1_N PF09779.9 EPA06415.1 - 0.053 14.4 2.6 0.06 14.2 2.6 1.1 1 0 0 1 1 1 0 Ima1 N-terminal domain zf-LITAF-like PF10601.9 EPA06415.1 - 0.2 11.9 3.1 6.3 7.1 3.3 2.0 1 1 0 1 1 1 0 LITAF-like zinc ribbon domain zf-C2H2_6 PF13912.6 EPA06415.1 - 0.34 11.0 5.0 2.5 8.2 0.9 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-RanBP PF00641.18 EPA06415.1 - 0.52 9.7 8.5 0.39 10.1 1.0 2.2 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others C1_2 PF03107.16 EPA06415.1 - 1.1 9.7 4.7 1.6 9.1 0.3 1.9 1 1 0 1 1 1 0 C1 domain zinc-ribbons_6 PF07191.12 EPA06417.1 - 0.017 15.1 8.6 0.022 14.8 8.6 1.3 1 0 0 1 1 1 0 zinc-ribbons DZR PF12773.7 EPA06417.1 - 0.17 11.9 10.4 0.17 11.9 9.2 1.6 1 1 0 1 1 1 0 Double zinc ribbon PolC_DP2 PF03833.13 EPA06417.1 - 0.19 9.5 5.0 0.18 9.6 5.0 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Tnp_zf-ribbon_2 PF13842.6 EPA06417.1 - 2.5 9.0 12.6 1.3e+02 3.5 12.6 2.9 1 1 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon SLATT_5 PF18160.1 EPA06418.1 - 0.0055 16.1 0.8 0.0055 16.1 0.8 1.7 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain family 5 Guanylate_cyc PF00211.20 EPA06419.1 - 2.3e-09 37.2 0.0 2.7e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PDT PF00800.18 EPA06422.1 - 4.3e-39 134.2 0.0 4.7e-39 134.1 0.0 1.0 1 0 0 1 1 1 1 Prephenate dehydratase Ribosomal_L37e PF01907.19 EPA06423.1 - 0.013 15.6 0.3 0.016 15.3 0.3 1.1 1 0 0 1 1 1 0 Ribosomal protein L37e Prok-RING_1 PF14446.6 EPA06423.1 - 0.014 15.3 0.5 0.017 15.1 0.5 1.1 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DNA_RNApol_7kD PF03604.13 EPA06423.1 - 0.19 11.4 8.0 2.9 7.6 8.0 2.1 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit zf-ACC PF17848.1 EPA06423.1 - 0.31 11.1 4.7 4.6 7.4 0.5 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain PhoU_div PF01865.16 EPA06425.1 - 2e-19 69.8 10.2 2.4e-19 69.5 10.2 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF47 PhoU PF01895.19 EPA06425.1 - 0.00063 20.2 11.6 0.0097 16.4 1.9 2.9 2 1 1 3 3 3 2 PhoU domain HATPase_c_5 PF14501.6 EPA06425.1 - 0.066 13.1 0.7 0.066 13.1 0.7 2.1 2 0 0 2 2 2 0 GHKL domain WD40_alt PF14077.6 EPA06425.1 - 0.2 11.6 0.3 0.2 11.6 0.3 2.4 3 0 0 3 3 3 0 Alternative WD40 repeat motif Lzipper-MIP1 PF14389.6 EPA06425.1 - 0.56 10.6 6.5 0.33 11.3 1.2 2.7 2 2 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 MCPsignal PF00015.21 EPA06425.1 - 0.6 9.9 11.2 12 5.6 9.3 3.1 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF2203 PF09969.9 EPA06425.1 - 2.4 8.9 6.7 5.9 7.6 1.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) S6OS1 PF15676.5 EPA06425.1 - 9.1 4.6 9.2 0.68 8.3 3.0 2.0 2 1 0 2 2 2 0 Six6 opposite strand transcript 1 family tRNA-synt_2 PF00152.20 EPA06426.1 - 3e-88 295.9 0.0 3.6e-88 295.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EPA06426.1 - 1.4e-11 44.2 1.0 2.6e-11 43.3 1.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EPA06426.1 - 0.014 14.9 0.1 0.17 11.3 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) bacHORMA_2 PF18173.1 EPA06426.1 - 0.16 11.8 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial HORMA domain 2 Memo PF01875.17 EPA06427.1 - 0.027 13.6 0.5 0.042 13.0 0.2 1.4 1 1 0 1 1 1 0 Memo-like protein Prp18 PF02840.15 EPA06427.1 - 0.089 12.8 2.6 0.17 12.0 2.6 1.5 1 1 0 1 1 1 0 Prp18 domain zinc_ribbon_10 PF10058.9 EPA06428.1 - 0.0007 19.3 1.1 0.00083 19.0 1.1 1.1 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein DNA_ligase_ZBD PF03119.16 EPA06428.1 - 0.0018 18.3 0.0 0.0026 17.7 0.0 1.3 1 1 0 1 1 1 1 NAD-dependent DNA ligase C4 zinc finger domain Auto_anti-p27 PF06677.12 EPA06428.1 - 0.0055 16.8 0.5 0.0069 16.5 0.5 1.2 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) IBR PF01485.21 EPA06428.1 - 0.025 14.8 1.0 0.027 14.7 1.0 1.0 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain DUF4379 PF14311.6 EPA06428.1 - 0.04 14.3 0.9 0.51 10.7 0.0 2.0 2 0 0 2 2 2 0 Probable Zinc-ribbon domain zf-TFIIB PF13453.6 EPA06428.1 - 0.044 13.1 2.2 0.89 8.9 0.1 2.1 2 0 0 2 2 2 0 Transcription factor zinc-finger zf-H2C2_2 PF13465.6 EPA06428.1 - 0.055 13.9 2.3 0.53 10.8 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger double domain Rubredoxin_2 PF18073.1 EPA06428.1 - 0.072 12.8 4.0 3.5 7.5 0.2 2.1 2 0 0 2 2 2 0 Rubredoxin metal binding domain PhnA_Zn_Ribbon PF08274.12 EPA06428.1 - 0.094 12.7 1.9 6.9 6.7 0.1 2.1 2 0 0 2 2 2 0 PhnA Zinc-Ribbon zinc_ribbon_9 PF14369.6 EPA06428.1 - 0.13 12.6 3.0 2.2 8.6 0.1 2.0 1 1 1 2 2 2 0 zinc-ribbon zf_UBZ PF18439.1 EPA06428.1 - 0.26 10.9 1.6 1.8 8.2 0.2 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf_C2H2_10 PF18414.1 EPA06428.1 - 0.3 10.6 3.6 2 8.0 0.3 2.1 2 0 0 2 2 2 0 C2H2 type zinc-finger zf-C2H2 PF00096.26 EPA06428.1 - 0.51 10.9 3.5 3.5 8.3 0.5 2.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type ABC_tran PF00005.27 EPA06430.1 - 4.7e-26 91.9 0.0 6.5e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 EPA06430.1 - 1.4e-17 64.0 0.1 2.3e-17 63.2 0.1 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 EPA06430.1 - 5.4e-06 26.4 0.5 3e-05 24.0 0.1 2.1 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EPA06430.1 - 0.0044 16.5 0.6 0.0084 15.6 0.6 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain PRK PF00485.18 EPA06430.1 - 0.089 12.5 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_29 PF13555.6 EPA06430.1 - 0.18 11.6 0.1 0.37 10.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_pol_Rbc25 PF08292.12 EPA06431.1 - 0.036 14.3 0.4 0.14 12.4 0.4 1.9 1 1 0 1 1 1 0 RNA polymerase III subunit Rpc25 Gal4_dimer PF03902.13 EPA06431.1 - 0.042 14.0 0.0 0.12 12.5 0.0 1.8 1 1 1 2 2 2 0 Gal4-like dimerisation domain Sbt_1 PF05982.12 EPA06434.1 - 9.6e-101 337.1 21.9 1.1e-100 336.9 21.9 1.0 1 0 0 1 1 1 1 Na+-dependent bicarbonate transporter superfamily DUF1772 PF08592.11 EPA06434.1 - 0.048 14.0 6.3 0.44 10.9 2.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) SHR3_chaperone PF08229.11 EPA06434.1 - 0.061 12.3 0.4 0.24 10.3 0.0 2.2 2 0 0 2 2 2 0 ER membrane protein SH3 EF1_GNE PF00736.19 EPA06435.1 - 0.022 14.9 0.1 0.032 14.4 0.1 1.3 1 0 0 1 1 1 0 EF-1 guanine nucleotide exchange domain DUF1454 PF07305.12 EPA06435.1 - 0.14 11.6 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1454) DNA_ligase_A_M PF01068.21 EPA06436.1 - 3.7e-61 206.3 0.5 8.1e-61 205.2 0.5 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EPA06436.1 - 1.9e-36 126.0 3.0 2.1e-36 125.9 1.6 1.8 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EPA06436.1 - 4.6e-22 78.5 0.0 1.2e-21 77.2 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EPA06436.1 - 2.2e-07 31.3 0.3 4.1e-07 30.5 0.3 1.5 1 0 0 1 1 1 1 RNA ligase T2SSE PF00437.20 EPA06437.1 - 3.6e-12 45.9 0.0 6.6e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein KH_2 PF07650.17 EPA06437.1 - 2.1e-07 30.7 2.6 3.1e-07 30.1 0.4 2.4 2 0 0 2 2 2 1 KH domain KH_1 PF00013.29 EPA06437.1 - 2.6e-07 30.4 0.3 2e-06 27.5 0.1 2.5 2 0 0 2 2 2 1 KH domain AAA_16 PF13191.6 EPA06437.1 - 5e-05 23.7 0.0 0.00013 22.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EPA06437.1 - 6.9e-05 22.9 0.0 0.00061 19.8 0.0 2.5 2 1 1 3 3 3 1 AAA domain AAA_25 PF13481.6 EPA06437.1 - 8.9e-05 22.1 0.0 0.00018 21.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain KH_5 PF13184.6 EPA06437.1 - 9.1e-05 22.5 1.1 0.00069 19.6 0.2 2.8 2 0 0 2 2 2 1 NusA-like KH domain AAA_18 PF13238.6 EPA06437.1 - 0.00016 22.3 0.0 0.002 18.7 0.0 2.8 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EPA06437.1 - 0.00027 20.7 0.0 0.00055 19.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein PIN_4 PF13638.6 EPA06437.1 - 0.0006 20.1 0.2 0.003 17.9 0.2 2.2 1 1 0 1 1 1 1 PIN domain AAA_22 PF13401.6 EPA06437.1 - 0.00091 19.5 0.1 0.026 14.8 0.0 2.9 3 0 0 3 3 3 1 AAA domain KH_4 PF13083.6 EPA06437.1 - 0.0031 17.3 0.1 0.01 15.7 0.1 1.8 1 0 0 1 1 1 1 KH domain ABC_tran PF00005.27 EPA06437.1 - 0.0042 17.6 0.0 0.019 15.5 0.0 2.1 2 0 0 2 2 1 1 ABC transporter AAA PF00004.29 EPA06437.1 - 0.0072 16.7 0.1 0.094 13.1 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 EPA06437.1 - 0.0074 15.3 0.0 0.025 13.6 0.0 1.8 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 EPA06437.1 - 0.011 16.0 0.0 0.023 15.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EPA06437.1 - 0.013 15.4 0.0 0.062 13.2 0.0 2.2 2 0 0 2 2 1 0 NTPase AAA_29 PF13555.6 EPA06437.1 - 0.018 14.8 0.1 0.057 13.2 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 EPA06437.1 - 0.02 14.9 0.0 0.049 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EPA06437.1 - 0.024 14.8 0.0 0.076 13.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain NACHT PF05729.12 EPA06437.1 - 0.038 13.9 0.0 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 EPA06437.1 - 0.042 13.6 0.0 0.13 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EPA06437.1 - 0.053 13.9 0.0 0.14 12.5 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.12 EPA06437.1 - 0.075 12.3 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Flt3_lig PF02947.14 EPA06437.1 - 0.087 13.0 0.1 0.28 11.4 0.0 1.8 2 0 0 2 2 1 0 flt3 ligand PIN_9 PF18477.1 EPA06437.1 - 0.098 13.0 0.3 0.63 10.4 0.3 2.5 1 1 0 1 1 1 0 PIN like domain ATP_bind_1 PF03029.17 EPA06437.1 - 0.11 12.2 0.1 0.23 11.2 0.1 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Mg_chelatase PF01078.21 EPA06437.1 - 0.13 11.7 0.0 0.34 10.3 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.18 EPA06437.1 - 0.15 11.8 0.0 0.33 10.6 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.6 EPA06437.1 - 0.16 12.4 1.0 0.53 10.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain M157 PF11624.8 EPA06438.1 - 0.13 11.5 0.1 0.14 11.4 0.1 1.1 1 0 0 1 1 1 0 MHC class I-like protein M157 Pur_DNA_glyco PF02245.16 EPA06441.1 - 1.3e-62 210.4 0.0 1.4e-62 210.2 0.0 1.0 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) adh_short PF00106.25 EPA06442.1 - 1.1e-39 136.0 0.1 2.9e-32 111.7 0.0 2.8 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EPA06442.1 - 1.3e-32 113.2 0.0 8.7e-24 84.4 0.0 3.5 4 0 0 4 4 4 3 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EPA06442.1 - 5.1e-13 49.3 0.0 1.1e-09 38.5 0.0 2.4 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EPA06442.1 - 1e-06 28.4 0.1 3.9e-06 26.5 0.0 2.0 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EPA06442.1 - 0.011 14.9 0.1 0.023 13.9 0.1 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ApoLp-III PF07464.11 EPA06442.1 - 0.015 15.4 2.6 0.36 10.9 0.5 2.5 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) F420_oxidored PF03807.17 EPA06442.1 - 0.037 14.6 0.3 0.18 12.4 0.1 2.4 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent SNARE_assoc PF09335.11 EPA06443.1 - 2e-16 60.6 0.8 2e-16 60.6 0.8 1.9 2 1 0 2 2 2 1 SNARE associated Golgi protein DUF1418 PF07214.12 EPA06443.1 - 0.0014 18.5 2.3 0.042 13.7 0.4 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1418) DUF697 PF05128.12 EPA06443.1 - 0.055 13.2 0.0 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF697) Glycophorin_A PF01102.18 EPA06443.1 - 0.055 13.7 0.6 7.9 6.8 0.0 2.3 2 0 0 2 2 2 0 Glycophorin A TauE PF01925.19 EPA06444.1 - 1.1e-52 179.1 33.9 1.3e-52 178.8 33.9 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE PMP22_Claudin PF00822.20 EPA06444.1 - 0.35 10.7 5.2 0.086 12.7 1.4 2.0 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family MFS_1 PF07690.16 EPA06446.1 - 8.4e-34 117.0 35.3 8.4e-34 117.0 35.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EPA06446.1 - 8.6e-31 107.3 32.5 4.2e-23 81.9 10.1 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.6 EPA06446.1 - 0.00045 18.9 10.6 0.00045 18.9 10.6 2.3 1 1 0 2 2 2 1 MFS/sugar transport protein Peptidase_M10 PF00413.24 EPA06448.1 - 0.0004 20.2 1.8 0.0075 16.1 1.8 2.6 1 1 0 1 1 1 1 Matrixin Peptidase_M66 PF10462.9 EPA06448.1 - 0.00093 18.2 0.0 0.0018 17.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase M66 Peptidase_M43 PF05572.13 EPA06448.1 - 0.0012 18.8 0.0 0.0024 17.8 0.0 1.5 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_4 PF13583.6 EPA06448.1 - 0.0012 18.5 0.3 0.0019 17.9 0.3 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 EPA06448.1 - 0.0016 19.0 0.4 0.005 17.4 0.0 2.1 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 EPA06448.1 - 0.0018 17.6 0.1 0.0031 16.8 0.1 1.3 1 0 0 1 1 1 1 Met-zincin Reprolysin_5 PF13688.6 EPA06448.1 - 0.0057 16.8 0.1 0.011 15.9 0.1 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M54 PF07998.11 EPA06448.1 - 0.014 15.4 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M54 Reprolysin_2 PF13574.6 EPA06448.1 - 0.033 14.1 0.0 0.058 13.3 0.0 1.5 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 EPA06448.1 - 0.043 13.4 0.8 0.086 12.5 0.8 1.6 1 1 0 1 1 1 0 Astacin (Peptidase family M12A) RuvB_C PF05491.13 EPA06448.1 - 0.058 13.3 1.4 0.19 11.6 0.3 2.4 3 0 0 3 3 3 0 RuvB C-terminal winged helix domain Peptidase_M57 PF12388.8 EPA06448.1 - 0.11 12.2 3.8 0.36 10.4 0.9 2.1 1 1 1 2 2 2 0 Dual-action HEIGH metallo-peptidase Zincin_1 PF06262.11 EPA06448.1 - 0.17 12.0 0.0 0.41 10.8 0.0 1.6 1 0 0 1 1 1 0 Zincin-like metallopeptidase NitrOD1 PF18549.1 EPA06449.1 - 2.4e-43 146.0 3.3 2.6e-43 145.8 3.3 1.0 1 0 0 1 1 1 1 Nitrosopumilus output domain 1 YolD PF08863.10 EPA06449.1 - 0.099 12.7 1.8 4.5 7.4 0.2 2.1 1 1 1 2 2 2 0 YolD-like protein DUF192 PF02643.15 EPA06450.1 - 3e-29 101.0 0.0 3.9e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, COG1430 Fe_dep_repress PF01325.19 EPA06451.1 - 3.6e-18 65.5 2.3 5.6e-18 64.9 2.3 1.3 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain Fe_dep_repr_C PF02742.15 EPA06451.1 - 4.2e-17 62.0 0.1 8.4e-17 61.0 0.1 1.5 1 0 0 1 1 1 1 Iron dependent repressor, metal binding and dimerisation domain DUF4423 PF14394.6 EPA06451.1 - 2.4e-07 30.6 0.4 5.6e-06 26.2 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4423) MarR_2 PF12802.7 EPA06451.1 - 0.00017 21.4 0.0 0.00027 20.7 0.0 1.3 1 0 0 1 1 1 1 MarR family MarR PF01047.22 EPA06451.1 - 0.00046 20.1 0.1 0.0014 18.5 0.0 1.8 2 0 0 2 2 2 1 MarR family HTH_Crp_2 PF13545.6 EPA06451.1 - 0.00048 20.1 0.0 0.0011 18.9 0.0 1.6 2 0 0 2 2 1 1 Crp-like helix-turn-helix domain HTH_45 PF14947.6 EPA06451.1 - 0.0011 19.0 1.1 0.0031 17.4 0.9 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix DUF2250 PF10007.9 EPA06451.1 - 0.0012 18.9 1.2 0.0019 18.3 0.5 1.7 2 1 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2250) TrmB PF01978.19 EPA06451.1 - 0.0014 18.5 0.2 0.0028 17.5 0.2 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB RexA PF15969.5 EPA06451.1 - 0.0026 17.4 0.1 0.0049 16.5 0.0 1.4 1 1 0 1 1 1 1 Intracellular sensor of Lambda phage, Abi component HTH_12 PF08461.10 EPA06451.1 - 0.0031 17.4 0.1 0.0066 16.4 0.1 1.6 1 1 0 1 1 1 1 Ribonuclease R winged-helix domain HipN PF18253.1 EPA06451.1 - 0.0053 16.4 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 Hsp70-interacting protein N N-terminal domain HTH_27 PF13463.6 EPA06451.1 - 0.0072 16.8 0.1 0.033 14.7 0.1 2.1 2 1 0 2 2 2 1 Winged helix DNA-binding domain HTH_24 PF13412.6 EPA06451.1 - 0.011 15.3 0.1 0.019 14.5 0.1 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding WYL_3 PF18488.1 EPA06451.1 - 0.012 16.0 0.2 0.074 13.4 0.1 2.1 2 0 0 2 2 2 0 WYL domain LexA_DNA_bind PF01726.16 EPA06451.1 - 0.014 15.2 0.0 0.036 13.8 0.0 1.7 2 0 0 2 2 2 0 LexA DNA binding domain HTH_IclR PF09339.10 EPA06451.1 - 0.033 14.0 0.0 0.055 13.3 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain NUMOD1 PF07453.13 EPA06451.1 - 0.038 14.2 0.0 11 6.4 0.0 3.3 3 0 0 3 3 3 0 NUMOD1 domain TFIIE_alpha PF02002.17 EPA06451.1 - 0.043 13.7 0.4 0.2 11.5 0.1 2.0 1 1 1 2 2 2 0 TFIIE alpha subunit Ribosomal_S19e PF01090.19 EPA06451.1 - 0.051 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S19e Rio2_N PF09202.11 EPA06451.1 - 0.056 13.7 0.1 0.12 12.6 0.1 1.6 1 1 0 1 1 1 0 Rio2, N-terminal HTH_1 PF00126.27 EPA06451.1 - 0.057 13.4 0.0 0.16 12.0 0.0 1.8 1 1 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family Rrf2 PF02082.20 EPA06451.1 - 0.066 13.6 0.1 0.13 12.6 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator GntR PF00392.21 EPA06451.1 - 0.077 12.7 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family DUF2624 PF11116.8 EPA06451.1 - 0.098 13.6 0.4 0.32 11.9 0.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2624) DUF190 PF02641.15 EPA06452.1 - 0.00076 19.8 0.1 0.0012 19.1 0.1 1.4 1 1 0 1 1 1 1 Uncharacterized ACR, COG1993 P-II PF00543.22 EPA06452.1 - 0.00083 19.9 0.0 0.0012 19.4 0.0 1.3 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II Nit_Regul_Hom PF10126.9 EPA06452.1 - 0.025 14.6 0.5 0.079 13.0 0.5 1.8 1 1 0 1 1 1 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII MetallophosC PF16370.5 EPA06452.1 - 0.09 13.0 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 C terminal of Calcineurin-like phosphoesterase DUF3240 PF11582.8 EPA06452.1 - 0.11 12.7 0.0 0.3 11.3 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3240) Claudin_2 PF13903.6 EPA06453.1 - 0.0012 18.6 2.8 0.0014 18.4 2.8 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.6 EPA06453.1 - 0.0041 17.4 6.5 0.0041 17.4 6.5 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF4064) PEMT PF04191.13 EPA06453.1 - 0.04 14.3 0.3 0.04 14.3 0.3 1.8 1 1 1 2 2 2 0 Phospholipid methyltransferase DUF2721 PF11026.8 EPA06453.1 - 0.2 11.6 6.4 0.31 10.9 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF2678 PF10856.8 EPA06453.1 - 0.22 11.5 4.0 0.29 11.1 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2678) DUF4747 PF15931.5 EPA06455.1 - 0.12 12.0 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4747) UDG PF03167.19 EPA06457.1 - 5.7e-39 133.6 0.0 7.3e-39 133.2 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Epimerase_2 PF02350.19 EPA06457.1 - 0.05 12.5 0.0 0.059 12.2 0.0 1.3 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase HATPase_c PF02518.26 EPA06460.1 - 1.5e-26 93.1 0.1 3.9e-26 91.8 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EPA06460.1 - 2.8e-15 56.1 1.5 7e-15 54.8 0.2 2.4 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 EPA06460.1 - 7.9e-08 32.6 0.0 3e-07 30.7 0.0 2.1 2 0 0 2 2 2 1 HAMP domain HATPase_c_3 PF13589.6 EPA06460.1 - 5e-05 23.1 0.1 0.00021 21.1 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PilJ PF13675.6 EPA06460.1 - 0.00033 20.7 0.0 0.038 14.0 0.0 2.8 2 0 0 2 2 2 1 Type IV pili methyl-accepting chemotaxis transducer N-term HATPase_c_2 PF13581.6 EPA06460.1 - 0.045 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain AtuA PF07287.11 EPA06460.1 - 0.045 12.5 0.2 0.076 11.7 0.2 1.2 1 0 0 1 1 1 0 Acyclic terpene utilisation family protein AtuA Myb_DNA-bind_3 PF12776.7 EPA06460.1 - 1.5 9.9 4.8 7.1 7.7 0.5 3.2 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain KH_5 PF13184.6 EPA06462.1 - 0.029 14.4 0.1 0.064 13.4 0.1 1.8 1 1 0 1 1 1 0 NusA-like KH domain Hpt PF01627.23 EPA06463.1 - 5.7e-05 23.3 0.0 7.3e-05 22.9 0.0 1.3 1 1 0 1 1 1 1 Hpt domain KRAP_IP3R_bind PF14722.6 EPA06463.1 - 0.014 15.1 0.1 0.022 14.5 0.1 1.3 1 0 0 1 1 1 0 Ki-ras-induced actin-interacting protein-IP3R-interacting domain KxDL PF10241.9 EPA06463.1 - 0.019 15.2 1.1 0.96 9.8 0.2 2.6 1 1 1 2 2 2 0 Uncharacterized conserved protein Syntaxin-6_N PF09177.11 EPA06463.1 - 0.022 15.3 0.5 0.096 13.2 0.3 2.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Seryl_tRNA_N PF02403.22 EPA06463.1 - 0.023 14.9 1.9 0.03 14.6 0.3 1.8 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Tweety PF04906.13 EPA06463.1 - 0.031 13.0 0.6 0.034 12.8 0.6 1.1 1 0 0 1 1 1 0 Tweety Vps51 PF08700.11 EPA06463.1 - 0.037 14.1 1.8 0.098 12.8 0.3 2.3 2 1 0 2 2 2 0 Vps51/Vps67 SesA PF17107.5 EPA06463.1 - 0.04 14.1 0.7 0.12 12.6 0.6 1.7 1 1 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases RPAP3_C PF13877.6 EPA06463.1 - 0.045 14.3 0.1 0.077 13.5 0.1 1.5 1 1 0 1 1 1 0 Potential Monad-binding region of RPAP3 DUF4559 PF15112.6 EPA06463.1 - 0.053 13.2 1.4 0.059 13.0 1.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Baculo_PEP_C PF04513.12 EPA06463.1 - 0.1 12.7 1.7 0.22 11.5 1.7 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.12 EPA06463.1 - 0.17 12.3 3.1 3.5 8.2 0.4 2.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 EPA06463.1 - 0.2 11.7 3.2 0.34 11.0 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 EPA06463.1 - 0.22 11.8 1.5 2 8.7 1.5 2.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) MCPsignal PF00015.21 EPA06463.1 - 0.77 9.6 5.7 8.1 6.2 5.7 2.1 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain FlaC_arch PF05377.11 EPA06463.1 - 1.1 9.7 7.2 3.7 8.0 2.0 3.2 2 2 0 2 2 2 0 Flagella accessory protein C (FlaC) MASE3 PF17159.4 EPA06464.1 - 0.022 14.4 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 Membrane-associated sensor domain DUF5447 PF17525.2 EPA06464.1 - 0.026 15.0 0.0 0.036 14.5 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5447) tRNA_int_endo PF01974.17 EPA06465.1 - 9.6e-27 92.9 0.0 1.6e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EPA06465.1 - 1.9e-17 62.7 0.0 3.6e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain Response_reg PF00072.24 EPA06466.1 - 3.8e-27 94.7 0.8 4.2e-27 94.5 0.8 1.0 1 0 0 1 1 1 1 Response regulator receiver domain Sulfotransfer_4 PF17784.1 EPA06466.1 - 0.077 12.8 0.0 0.086 12.7 0.0 1.1 1 0 0 1 1 1 0 Sulfotransferase domain PLDc_2 PF13091.6 EPA06467.1 - 0.0022 17.9 0.9 0.049 13.5 0.9 2.4 1 1 0 1 1 1 1 PLD-like domain Regulator_TrmB PF11495.8 EPA06467.1 - 0.0025 17.0 0.7 0.016 14.4 0.7 1.9 1 1 0 1 1 1 1 Archaeal transcriptional regulator TrmB RAMA PF18755.1 EPA06467.1 - 0.0037 17.6 0.0 3.3 8.2 0.0 2.2 2 0 0 2 2 2 2 Restriction Enzyme Adenine Methylase Associated PhdYeFM_antitox PF02604.19 EPA06467.1 - 0.09 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system Hydrolase_4 PF12146.8 EPA06468.1 - 4.2e-38 131.0 0.0 5.5e-38 130.6 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EPA06468.1 - 7.1e-19 68.5 0.1 9.5e-15 54.9 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EPA06468.1 - 1.8e-12 48.3 0.0 2.4e-12 47.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 EPA06468.1 - 0.00024 20.8 0.1 0.00066 19.3 0.1 1.8 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase DUF1749 PF08538.10 EPA06468.1 - 0.0005 19.2 0.0 0.0009 18.4 0.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1749) Peptidase_S9 PF00326.21 EPA06468.1 - 0.00054 19.5 0.0 0.004 16.6 0.0 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family Ser_hydrolase PF06821.13 EPA06468.1 - 0.00074 19.4 0.0 0.0017 18.3 0.0 1.6 1 0 0 1 1 1 1 Serine hydrolase Tannase PF07519.11 EPA06468.1 - 0.0016 17.5 0.0 0.024 13.6 0.1 2.0 1 1 1 2 2 2 1 Tannase and feruloyl esterase FSH1 PF03959.13 EPA06468.1 - 0.002 17.8 0.1 0.036 13.7 0.0 2.3 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Peptidase_S15 PF02129.18 EPA06468.1 - 0.0023 17.6 0.0 0.99 8.9 0.0 2.1 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 EPA06468.1 - 0.01 15.4 0.0 0.63 9.6 0.1 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Chlorophyllase2 PF12740.7 EPA06468.1 - 0.024 13.6 0.0 0.12 11.2 0.0 2.1 2 1 0 2 2 2 0 Chlorophyllase enzyme DUF1057 PF06342.12 EPA06468.1 - 0.031 13.3 0.0 0.048 12.7 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_5 PF12695.7 EPA06468.1 - 0.066 13.0 0.0 1.5 8.6 0.0 2.6 3 0 0 3 3 3 0 Alpha/beta hydrolase family DUF1350 PF07082.11 EPA06468.1 - 0.067 12.5 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1350) Methyltransf_31 PF13847.6 EPA06470.1 - 1.2e-16 60.9 0.0 1.7e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA06470.1 - 1.3e-13 51.5 0.0 2.3e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EPA06470.1 - 1.8e-13 50.7 0.0 2.7e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA06470.1 - 5.3e-12 46.2 0.0 8.2e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EPA06470.1 - 3.8e-08 32.9 0.0 5.5e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EPA06470.1 - 1.3e-07 32.3 0.0 3.5e-07 30.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EPA06470.1 - 5.8e-07 29.5 0.0 1e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EPA06470.1 - 4.3e-05 23.1 0.2 9e-05 22.1 0.1 1.7 2 1 0 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EPA06470.1 - 4.7e-05 22.8 0.2 8.3e-05 22.0 0.1 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EPA06470.1 - 0.00024 21.2 0.1 0.0014 18.8 0.1 2.0 1 1 1 2 2 2 1 FtsJ-like methyltransferase TehB PF03848.14 EPA06470.1 - 0.00062 19.2 0.3 0.00094 18.6 0.3 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB CheR PF01739.18 EPA06470.1 - 0.002 17.6 0.9 0.02 14.4 0.4 2.2 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain PrmA PF06325.13 EPA06470.1 - 0.0093 15.4 0.1 0.014 14.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) N6_N4_Mtase PF01555.18 EPA06470.1 - 0.01 15.6 0.1 0.2 11.4 0.0 2.2 2 0 0 2 2 2 1 DNA methylase Methyltransf_32 PF13679.6 EPA06470.1 - 0.01 15.8 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 EPA06470.1 - 0.031 13.9 0.1 0.068 12.7 0.1 1.6 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.11 EPA06470.1 - 0.039 12.9 0.0 0.068 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) DREV PF05219.12 EPA06470.1 - 0.043 12.9 0.1 0.082 12.0 0.1 1.4 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_4 PF02390.17 EPA06470.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase TrmB PF01978.19 EPA06471.1 - 0.028 14.3 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF1129 PF06570.11 EPA06472.1 - 0.00022 20.8 0.0 0.00022 20.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) PrgI PF12666.7 EPA06472.1 - 0.017 15.8 0.3 0.02 15.6 0.3 1.1 1 0 0 1 1 1 0 PrgI family protein DUF2178 PF09946.9 EPA06472.1 - 0.023 14.8 0.0 0.029 14.5 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2178) DUF2207 PF09972.9 EPA06472.1 - 0.091 11.5 0.0 0.098 11.4 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EMP70 PF02990.16 EPA06472.1 - 0.13 10.9 1.8 0.14 10.8 1.8 1.0 1 0 0 1 1 1 0 Endomembrane protein 70 UbiA PF01040.18 EPA06473.1 - 7.4e-28 97.5 14.7 1e-27 97.0 14.7 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family NAD_binding_10 PF13460.6 EPA06474.1 - 7.7e-15 55.3 0.0 1.2e-14 54.6 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EPA06474.1 - 2.2e-11 43.7 0.1 1.1e-10 41.4 0.1 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EPA06474.1 - 2.6e-11 43.5 0.0 3.7e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 EPA06474.1 - 1.3e-10 40.7 0.0 2e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EPA06474.1 - 4.7e-06 26.2 0.1 7.7e-06 25.5 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EPA06474.1 - 0.00065 19.2 0.1 0.0037 16.8 0.1 2.2 2 1 0 2 2 2 1 short chain dehydrogenase NAD_binding_4 PF07993.12 EPA06474.1 - 0.002 17.4 0.1 0.0054 15.9 0.0 1.8 3 0 0 3 3 3 1 Male sterility protein RmlD_sub_bind PF04321.17 EPA06474.1 - 0.0025 16.9 0.0 0.0042 16.2 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EPA06474.1 - 0.0056 15.9 1.2 0.1 11.7 1.2 2.2 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EPA06474.1 - 0.016 15.1 0.4 0.09 12.7 0.4 2.0 1 1 0 1 1 1 0 KR domain NAD_binding_2 PF03446.15 EPA06474.1 - 0.15 12.2 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ATPase_gene1 PF09527.10 EPA06476.1 - 0.097 12.9 1.5 0.14 12.3 1.5 1.4 1 1 0 1 1 1 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Diphthamide_syn PF01866.17 EPA06477.1 - 5.7e-34 117.9 0.0 6.3e-34 117.8 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein TPR_1 PF00515.28 EPA06478.1 - 2.3e-10 39.8 2.2 0.0001 22.0 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EPA06478.1 - 7.1e-08 32.0 0.1 0.054 13.6 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EPA06478.1 - 6e-06 26.7 0.0 0.00022 21.6 0.0 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EPA06478.1 - 0.00042 20.3 0.2 0.051 13.7 0.1 2.9 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat SRP_TPR_like PF17004.5 EPA06478.1 - 0.00056 19.9 0.1 0.013 15.5 0.1 2.0 1 1 0 1 1 1 1 Putative TPR-like repeat TPR_14 PF13428.6 EPA06478.1 - 0.002 18.8 0.0 5.1 8.2 0.0 3.5 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EPA06478.1 - 0.0032 17.5 2.2 7.1 7.1 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EPA06478.1 - 0.0082 16.4 0.0 3.8 7.9 0.0 2.4 2 1 1 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EPA06478.1 - 0.015 15.5 0.7 0.54 10.5 0.3 2.1 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EPA06478.1 - 0.018 14.7 0.1 17 5.2 0.1 3.5 3 0 0 3 3 3 0 TPR repeat TPR_6 PF13174.6 EPA06478.1 - 0.029 15.0 0.0 6 7.7 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EPA06478.1 - 0.066 13.6 0.5 65 4.2 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ATP13 PF12921.7 EPA06478.1 - 0.089 12.7 0.0 1.3 8.9 0.0 2.1 1 1 1 2 2 2 0 Mitochondrial ATPase expression TPR_16 PF13432.6 EPA06478.1 - 0.14 12.8 0.0 0.31 11.7 0.0 1.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Diphthamide_syn PF01866.17 EPA06479.1 - 2e-34 119.4 0.0 2.2e-34 119.3 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein TPR_1 PF00515.28 EPA06480.1 - 2.4e-10 39.8 3.1 9.9e-05 22.0 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EPA06480.1 - 2e-08 33.7 0.4 0.028 14.5 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EPA06480.1 - 1.7e-05 25.2 0.0 0.00014 22.3 0.0 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EPA06480.1 - 8.7e-05 22.5 0.2 0.052 13.6 0.1 3.2 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 EPA06480.1 - 0.00048 19.8 0.3 3.3 7.5 0.0 4.2 4 0 0 4 4 4 1 TPR repeat TPR_14 PF13428.6 EPA06480.1 - 0.00073 20.2 0.0 5.1 8.2 0.0 3.6 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EPA06480.1 - 0.015 15.6 0.0 2.6 8.4 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EPA06480.1 - 0.022 14.9 4.2 5.9 7.4 0.1 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EPA06480.1 - 0.028 15.0 0.0 8.2 7.3 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EPA06480.1 - 0.037 14.2 1.4 0.42 10.9 1.1 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 ATP13 PF12921.7 EPA06480.1 - 0.041 13.7 0.0 1.1 9.2 0.0 2.3 1 1 1 2 2 2 0 Mitochondrial ATPase expression DMP12 PF16779.5 EPA06480.1 - 0.059 13.4 0.1 0.21 11.6 0.1 1.9 1 1 1 2 2 2 0 DNA-mimic protein TPR_17 PF13431.6 EPA06480.1 - 0.16 12.4 1.8 64 4.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EPA06480.1 - 0.2 12.3 0.0 2 9.1 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat MscL PF01741.18 EPA06482.1 - 5.3e-21 75.2 7.5 5.8e-21 75.0 7.5 1.0 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL Reticulon PF02453.17 EPA06482.1 - 0.0015 18.5 0.6 0.0018 18.2 0.6 1.1 1 0 0 1 1 1 1 Reticulon FtsX PF02687.21 EPA06482.1 - 0.023 15.1 5.9 0.035 14.6 5.9 1.3 1 0 0 1 1 1 0 FtsX-like permease family DUF1449 PF07290.11 EPA06482.1 - 0.042 13.5 0.6 0.042 13.5 0.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1449) DUF3951 PF13131.6 EPA06482.1 - 5.9 7.2 9.7 1.9 8.7 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3951) Polyketide_cyc2 PF10604.9 EPA06484.1 - 5.5e-14 52.6 0.0 6.2e-14 52.5 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 EPA06484.1 - 0.028 14.6 0.0 0.032 14.4 0.0 1.1 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport GAS PF13851.6 EPA06485.1 - 0.00042 19.7 29.7 0.0039 16.6 5.5 2.9 2 1 0 2 2 2 2 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 EPA06485.1 - 0.00046 19.2 31.2 0.014 14.3 6.9 3.1 2 1 0 2 2 2 2 Spc7 kinetochore protein AAA_13 PF13166.6 EPA06485.1 - 0.00085 18.1 35.3 0.0026 16.5 14.0 2.2 1 1 1 2 2 2 2 AAA domain Baculo_PEP_C PF04513.12 EPA06485.1 - 0.00096 19.2 1.7 0.00096 19.2 1.7 5.1 1 1 4 5 5 5 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 EPA06485.1 - 0.0022 18.2 23.1 0.4 11.0 1.0 5.6 4 2 1 5 5 5 2 Bacterial protein of unknown function (DUF948) CENP-F_leu_zip PF10473.9 EPA06485.1 - 0.0024 17.9 5.6 0.0024 17.9 5.6 3.8 3 2 1 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 EPA06485.1 - 0.0025 18.3 27.5 0.016 15.7 4.4 2.9 2 1 1 3 3 3 2 Apg6 coiled-coil region Snapin_Pallidin PF14712.6 EPA06485.1 - 0.0045 17.4 4.9 0.0045 17.4 4.9 4.9 2 1 2 5 5 5 1 Snapin/Pallidin BEN PF10523.9 EPA06485.1 - 0.02 15.1 1.8 0.053 13.8 0.2 2.6 3 0 0 3 3 2 0 BEN domain Imm30 PF15565.6 EPA06485.1 - 0.026 14.6 0.4 0.026 14.6 0.4 3.3 2 2 0 2 2 2 0 Immunity protein 30 XhlA PF10779.9 EPA06485.1 - 0.033 14.4 2.4 0.033 14.4 2.4 5.1 3 2 2 5 5 4 0 Haemolysin XhlA HOOK PF05622.12 EPA06485.1 - 0.04 12.1 33.8 0.3 9.2 17.0 2.3 1 1 0 2 2 2 0 HOOK protein HemX PF04375.14 EPA06485.1 - 0.04 13.2 16.1 0.29 10.4 6.5 2.9 2 1 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Pullulanase_Ins PF18494.1 EPA06485.1 - 0.13 12.7 3.2 0.5 10.9 0.3 2.9 2 0 0 2 2 2 0 Pullulanase Ins domain DUF4349 PF14257.6 EPA06485.1 - 0.2 11.1 6.8 3.2 7.1 0.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4349) DUF4351 PF14261.6 EPA06485.1 - 0.21 11.7 10.8 10 6.2 0.1 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4351) Cep57_CLD_2 PF14197.6 EPA06485.1 - 0.23 11.6 5.9 0.72 10.0 0.1 2.9 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 DHR10 PF18595.1 EPA06485.1 - 0.3 11.2 27.1 0.26 11.4 8.7 3.5 2 2 0 2 2 2 0 Designed helical repeat protein 10 domain Vac_Fusion PF02346.16 EPA06485.1 - 0.3 10.7 4.7 12 5.6 0.1 3.7 3 1 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Tropomyosin_1 PF12718.7 EPA06485.1 - 0.31 11.2 22.8 0.22 11.7 8.0 3.1 2 1 0 2 2 2 0 Tropomyosin like CLZ PF16526.5 EPA06485.1 - 0.39 11.1 22.3 0.27 11.6 2.9 4.9 2 2 2 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels BLOC1_2 PF10046.9 EPA06485.1 - 0.47 10.8 34.5 0.069 13.5 7.3 5.2 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Phage_GPO PF05929.11 EPA06485.1 - 0.54 9.8 16.6 0.53 9.8 5.7 2.6 1 1 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF3450 PF11932.8 EPA06485.1 - 0.57 9.4 25.9 2 7.6 3.0 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) Rx_N PF18052.1 EPA06485.1 - 0.65 10.3 16.6 0.06 13.6 1.2 3.9 3 2 0 3 3 3 0 Rx N-terminal domain FapA PF03961.13 EPA06485.1 - 1.3 7.5 35.6 0.11 11.1 11.9 3.1 1 1 1 3 3 3 0 Flagellar Assembly Protein A Alpha-E PF04168.12 EPA06485.1 - 1.3 8.7 8.2 7.8 6.2 1.8 2.9 2 1 0 2 2 2 0 A predicted alpha-helical domain with a conserved ER motif. DUF4407 PF14362.6 EPA06485.1 - 2.6 7.3 13.1 0.35 10.2 5.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.12 EPA06485.1 - 3.1 8.3 39.3 0.13 12.7 1.9 6.6 3 3 3 6 6 6 0 Nucleopolyhedrovirus P10 protein TPR_MLP1_2 PF07926.12 EPA06485.1 - 7.8 6.6 26.4 6 6.9 6.1 4.0 2 2 2 4 4 4 0 TPR/MLP1/MLP2-like protein AsnC_trans_reg PF01037.21 EPA06486.1 - 1.5e-09 37.7 0.1 1.8e-09 37.4 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain DUF4795 PF16043.5 EPA06486.1 - 0.022 14.4 1.0 0.023 14.3 1.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Flu_M1_C PF08289.11 EPA06486.1 - 0.032 14.4 0.2 2.8 8.2 0.0 2.0 1 1 1 2 2 2 0 Influenza Matrix protein (M1) C-terminal domain NEXCaM_BD PF16644.5 EPA06486.1 - 0.059 13.6 0.3 0.078 13.2 0.2 1.3 1 1 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin GLTP PF08718.11 EPA06486.1 - 0.061 13.6 0.3 0.066 13.5 0.3 1.0 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) Guanylate_cyc PF00211.20 EPA06491.1 - 0.031 13.9 0.1 0.048 13.3 0.1 1.3 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Prok-JAB PF14464.6 EPA06493.1 - 3e-12 46.3 0.0 4.6e-12 45.8 0.0 1.3 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain AHSA1 PF08327.11 EPA06494.1 - 6.4e-21 74.9 0.3 7.2e-21 74.7 0.3 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 EPA06494.1 - 0.033 14.4 0.1 0.042 14.1 0.1 1.5 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport DUF960 PF06124.11 EPA06494.1 - 0.04 14.5 0.1 0.061 14.0 0.1 1.4 1 0 0 1 1 1 0 Staphylococcal protein of unknown function (DUF960) S_locus_glycop PF00954.20 EPA06494.1 - 0.042 14.4 0.3 0.068 13.7 0.3 1.3 1 0 0 1 1 1 0 S-locus glycoprotein domain DUF4064 PF13273.6 EPA06495.1 - 0.0019 18.5 1.2 0.0026 18.0 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) DUF2207 PF09972.9 EPA06495.1 - 0.077 11.7 0.1 0.095 11.4 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3185 PF11381.8 EPA06495.1 - 0.27 11.3 5.9 2.1 8.4 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) DUF2628 PF10947.8 EPA06496.1 - 0.58 10.6 6.3 5.9 7.3 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2628) Sensor_TM1 PF13755.6 EPA06496.1 - 0.63 9.8 4.6 8.4 6.2 0.7 2.4 2 0 0 2 2 2 0 Sensor N-terminal transmembrane domain Phage_holin_1 PF04531.13 EPA06496.1 - 0.95 10.0 7.8 0.19 12.3 1.0 2.5 1 1 2 3 3 3 0 Bacteriophage holin malic PF00390.19 EPA06504.1 - 8.8e-26 90.8 7.2 3.1e-23 82.5 0.4 3.6 2 2 0 2 2 2 1 Malic enzyme, N-terminal domain Malic_M PF03949.15 EPA06504.1 - 1.7e-25 89.8 5.2 1.1e-24 87.1 5.2 2.2 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain AdoHcyase_NAD PF00670.21 EPA06504.1 - 0.00012 22.2 2.3 0.0015 18.6 1.3 2.9 2 1 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Shikimate_DH PF01488.20 EPA06504.1 - 0.00093 19.3 0.1 0.0021 18.1 0.1 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 EPA06504.1 - 0.003 16.9 0.8 0.0058 16.0 0.8 1.4 1 0 0 1 1 1 1 ThiF family FAD_binding_3 PF01494.19 EPA06504.1 - 0.0064 15.8 0.0 0.0094 15.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain ELFV_dehydrog PF00208.21 EPA06504.1 - 0.021 14.6 0.8 0.049 13.3 0.3 1.8 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase THF_DHG_CYH_C PF02882.19 EPA06504.1 - 0.19 11.0 2.8 2.8 7.2 0.2 3.6 4 1 0 4 4 4 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Phage_int_SAM_3 PF14659.6 EPA06504.1 - 2.9 8.2 9.6 7.2 7.0 0.1 4.2 5 0 0 5 5 5 0 Phage integrase, N-terminal SAM-like domain DUF3892 PF13031.6 EPA06506.1 - 0.056 14.1 0.5 0.096 13.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3892) SlyX PF04102.12 EPA06506.1 - 0.056 14.1 1.6 0.075 13.7 0.6 1.8 2 0 0 2 2 2 0 SlyX Prefoldin_2 PF01920.20 EPA06506.1 - 0.28 11.1 7.9 1.4 8.9 4.9 2.3 2 0 0 2 2 2 0 Prefoldin subunit DUF2680 PF10925.8 EPA06506.1 - 0.42 10.7 2.8 1.7 8.7 3.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) Seryl_tRNA_N PF02403.22 EPA06506.1 - 1.5 9.1 6.9 0.6 10.4 2.4 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Glyc_hyd_38C_2 PF18230.1 EPA06507.1 - 0.18 11.9 0.1 1.9 8.6 0.0 2.1 2 0 0 2 2 2 0 Glycosyl hydrolases family 38 C-terminal sub-domain tRNA-synt_1 PF00133.22 EPA06508.1 - 7.7e-16 57.5 0.2 3e-15 55.5 0.2 1.7 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EPA06508.1 - 1.6e-10 40.3 0.0 2.6e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EPA06508.1 - 9e-07 28.5 0.0 1.3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain CHB_HEX_C PF03174.13 EPA06508.1 - 0.15 12.1 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain Calci_bind_CcbP PF11535.8 EPA06513.1 - 0.1 13.1 2.7 4.2 7.9 0.0 2.5 2 1 0 2 2 2 0 Calcium binding DUF87 PF01935.17 EPA06514.1 - 2.6e-17 63.7 0.9 2e-16 60.8 0.4 2.4 1 1 1 2 2 2 1 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 EPA06514.1 - 0.00032 20.1 0.0 0.006 16.0 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family FliH PF02108.16 EPA06514.1 - 0.0039 17.3 0.6 0.011 15.8 0.2 1.9 2 0 0 2 2 2 1 Flagellar assembly protein FliH TrwB_AAD_bind PF10412.9 EPA06514.1 - 0.0078 15.2 0.0 0.022 13.7 0.0 1.7 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain MMR_HSR1 PF01926.23 EPA06514.1 - 0.053 13.6 0.1 0.16 12.1 0.1 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA PF00004.29 EPA06514.1 - 0.074 13.5 1.3 7 7.1 0.0 3.5 2 2 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) HisK_N PF09385.10 EPA06515.1 - 0.036 14.0 0.1 0.5 10.3 0.0 2.6 2 0 0 2 2 2 0 Histidine kinase N terminal H2O2_YaaD PF03883.14 EPA06516.1 - 5.2e-05 22.9 0.9 0.00012 21.7 0.9 1.6 1 0 0 1 1 1 1 Peroxide stress protein YaaA DUF5591 PF17884.1 EPA06516.1 - 0.0089 15.9 0.9 6.7 6.5 0.0 3.1 3 1 1 4 4 4 2 Domain of unknown function (DUF5591) TGT PF01702.18 EPA06516.1 - 0.061 12.5 0.0 0.36 9.9 0.0 2.1 2 0 0 2 2 2 0 Queuine tRNA-ribosyltransferase QueC PF06508.13 EPA06517.1 - 7.4e-66 221.6 0.0 8.3e-66 221.5 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC ATP_bind_3 PF01171.20 EPA06517.1 - 0.0066 16.2 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 PP-loop family Diphthami_syn_2 PF01902.17 EPA06517.1 - 0.011 15.2 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 Diphthamide synthase NAD_synthase PF02540.17 EPA06517.1 - 0.019 14.1 0.0 0.11 11.6 0.0 1.9 2 0 0 2 2 2 0 NAD synthase tRNA_Me_trans PF03054.16 EPA06517.1 - 0.048 12.4 0.0 0.073 11.8 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase Asn_synthase PF00733.21 EPA06517.1 - 0.057 13.1 0.0 0.082 12.6 0.0 1.1 1 0 0 1 1 1 0 Asparagine synthase ThiI PF02568.14 EPA06517.1 - 0.07 12.7 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Q_salvage PF10343.9 EPA06518.1 - 6.8e-11 42.3 0.7 6.3e-09 35.8 0.7 2.2 1 1 0 1 1 1 1 Potential Queuosine, Q, salvage protein family EF-hand_1 PF00036.32 EPA06518.1 - 0.066 12.8 0.5 0.18 11.4 0.5 1.8 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 EPA06518.1 - 3 8.0 4.6 0.68 10.0 0.5 2.1 2 0 0 2 2 2 0 EF-hand domain Cor1 PF04803.12 EPA06520.1 - 0.01 16.0 1.3 0.013 15.8 1.3 1.0 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region SAPS PF04499.15 EPA06520.1 - 0.016 14.0 0.0 0.017 14.0 0.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Lip_prot_lig_C PF10437.9 EPA06520.1 - 0.05 13.6 0.6 0.91 9.6 0.0 2.0 1 1 1 2 2 2 0 Bacterial lipoate protein ligase C-terminus DUF4187 PF13821.6 EPA06521.1 - 0.033 14.0 0.1 0.033 14.0 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4187) Transp_Tc5_C PF04236.15 EPA06521.1 - 0.067 13.6 9.1 0.11 12.9 9.1 1.3 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain RHH_3 PF12651.7 EPA06521.1 - 0.19 11.7 1.4 0.46 10.5 1.4 1.7 1 1 0 1 1 1 0 Ribbon-helix-helix domain PTPS PF01242.19 EPA06522.1 - 3.2e-25 88.5 0.0 3.6e-25 88.3 0.0 1.0 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase DUF2326 PF10088.9 EPA06522.1 - 0.065 13.0 0.3 0.094 12.5 0.3 1.4 1 1 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2326) IMPDH PF00478.25 EPA06523.1 - 4.2e-79 266.1 8.9 4.9e-79 265.8 8.9 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EPA06523.1 - 1.7e-06 27.3 4.5 1.8e-06 27.2 3.5 1.5 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 EPA06523.1 - 3.5e-06 26.6 4.0 5.3e-06 26.0 4.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase DHO_dh PF01180.21 EPA06523.1 - 0.0003 20.1 1.3 0.0003 20.1 1.3 1.8 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 EPA06523.1 - 0.001 18.5 0.6 0.0029 17.1 0.1 1.9 1 1 1 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 EPA06523.1 - 0.013 14.9 0.9 0.024 13.9 0.4 1.5 1 1 0 1 1 1 0 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 EPA06523.1 - 0.028 13.6 3.4 0.041 13.0 3.4 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase NanE PF04131.14 EPA06523.1 - 0.062 12.5 2.5 0.53 9.4 0.1 2.1 1 1 1 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase Fil_haemagg PF05594.14 EPA06525.1 - 0.011 16.2 5.9 0.011 16.2 5.9 3.1 1 1 2 3 3 3 0 Haemagluttinin repeat Diphthamide_syn PF01866.17 EPA06529.1 - 1.2e-09 38.0 0.0 1.4e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein TFIIE_alpha PF02002.17 EPA06530.1 - 1.9e-15 56.6 0.8 1.9e-15 56.6 0.8 1.5 2 0 0 2 2 2 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.12 EPA06530.1 - 0.0049 16.4 0.8 0.011 15.3 0.8 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding IBR PF01485.21 EPA06530.1 - 0.051 13.8 0.8 0.081 13.2 0.8 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain TrmB PF01978.19 EPA06530.1 - 0.071 13.0 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Sigma70_r3 PF04539.16 EPA06530.1 - 0.075 13.1 0.4 0.2 11.7 0.0 1.9 2 0 0 2 2 2 0 Sigma-70 region 3 zf-ACC PF17848.1 EPA06530.1 - 0.076 13.1 0.7 0.29 11.2 0.2 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain DUF3834 PF12916.7 EPA06530.1 - 0.08 12.2 0.1 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) zf-ribbon_3 PF13248.6 EPA06530.1 - 0.16 11.4 0.1 0.16 11.4 0.1 1.9 2 0 0 2 2 2 0 zinc-ribbon domain Zn_ribbon_recom PF13408.6 EPA06530.1 - 0.18 12.3 0.1 0.18 12.3 0.1 2.3 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain Methyltransf_11 PF08241.12 EPA06531.1 - 8.6e-08 32.7 0.0 1.2e-07 32.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA06531.1 - 1.8e-06 28.6 0.0 2.9e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 EPA06531.1 - 5.5e-06 26.2 0.0 6.1e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_12 PF08242.12 EPA06531.1 - 5.7e-06 27.0 0.0 1.4e-05 25.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA06531.1 - 3.1e-05 23.8 0.1 3.4e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EPA06531.1 - 0.0016 18.3 0.0 0.0019 18.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EPA06531.1 - 0.0023 17.3 0.1 0.0029 17.0 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EPA06531.1 - 0.059 12.7 0.0 0.069 12.5 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Trm56 PF01994.16 EPA06532.1 - 4.8e-49 165.2 0.6 6.4e-49 164.8 0.3 1.3 2 0 0 2 2 2 1 tRNA ribose 2'-O-methyltransferase, aTrm56 SPOUT_MTase_2 PF14419.6 EPA06532.1 - 0.00056 19.3 0.0 0.00074 18.9 0.0 1.3 1 0 0 1 1 1 1 AF2226-like SPOUT RNA Methylase fused to THUMP SSB PF00436.25 EPA06532.1 - 0.039 14.0 0.2 0.46 10.6 0.1 2.2 2 0 0 2 2 2 0 Single-strand binding protein family HMG_box_2 PF09011.10 EPA06532.1 - 0.046 14.3 0.2 0.098 13.3 0.2 1.5 1 0 0 1 1 1 0 HMG-box domain Methyltransf_23 PF13489.6 EPA06532.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltrn_RNA_4 PF09936.9 EPA06532.1 - 0.13 12.1 0.1 4.5 7.1 0.0 2.2 1 1 1 2 2 2 0 SAM-dependent RNA methyltransferase DUF3085 PF11284.8 EPA06532.1 - 0.15 12.4 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3085) GTP-bdg_N PF13167.6 EPA06533.1 - 7.4e-19 68.2 0.5 3e-18 66.3 0.1 2.3 3 0 0 3 3 2 1 GTP-binding GTPase N-terminal MMR_HSR1 PF01926.23 EPA06533.1 - 6.7e-18 64.8 0.3 3.9e-17 62.4 0.1 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP-bdg_M PF16360.5 EPA06533.1 - 9.8e-16 58.1 3.2 2.3e-15 57.0 3.2 1.7 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region FeoB_N PF02421.18 EPA06533.1 - 2.1e-09 37.1 0.2 4.2e-09 36.1 0.2 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EPA06533.1 - 3.8e-06 26.9 5.2 0.0034 17.3 0.2 2.5 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EPA06533.1 - 0.00013 21.6 2.7 0.012 15.1 0.4 2.5 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EPA06533.1 - 0.0041 16.6 2.0 0.0083 15.6 2.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit cobW PF02492.19 EPA06533.1 - 0.0087 15.7 4.3 0.8 9.3 0.2 2.4 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain Arf PF00025.21 EPA06533.1 - 0.01 15.3 4.7 0.056 12.9 4.0 2.4 1 1 0 1 1 1 0 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 EPA06533.1 - 0.012 15.6 1.0 0.04 13.9 0.3 2.2 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain T2SSE PF00437.20 EPA06533.1 - 0.017 14.2 0.1 0.034 13.2 0.1 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Roc PF08477.13 EPA06533.1 - 0.019 15.2 0.3 0.91 9.8 0.1 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 EPA06533.1 - 0.024 15.2 0.2 0.076 13.5 0.2 2.0 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 EPA06533.1 - 0.031 14.0 6.2 0.49 10.1 4.9 3.1 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 EPA06533.1 - 0.033 14.2 1.8 0.58 10.2 0.4 2.9 2 1 1 3 3 3 0 Dynamin family DUF1192 PF06698.11 EPA06533.1 - 0.066 13.3 1.9 1.1 9.4 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) MobB PF03205.14 EPA06533.1 - 0.12 12.3 1.0 0.4 10.6 0.1 2.3 2 1 1 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B Remorin_C PF03763.13 EPA06533.1 - 0.14 12.0 0.1 0.14 12.0 0.1 2.6 3 0 0 3 3 3 0 Remorin, C-terminal region Phage_integrase PF00589.22 EPA06534.1 - 2.3e-06 27.5 0.1 0.0074 16.1 0.1 2.5 2 0 0 2 2 2 2 Phage integrase family GatB_N PF02934.15 EPA06537.1 - 1.3e-70 238.0 0.0 1.5e-70 237.7 0.0 1.0 1 0 0 1 1 1 1 GatB/GatE catalytic domain Sulfolobus_pRN PF05584.11 EPA06538.1 - 0.1 12.6 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Sulfolobus plasmid regulatory protein tRNA-synt_2 PF00152.20 EPA06539.1 - 2.6e-22 79.3 0.0 2.8e-22 79.2 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 EPA06539.1 - 0.0089 15.5 0.0 0.0089 15.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2e PF02091.15 EPA06539.1 - 0.061 12.6 0.0 0.071 12.4 0.0 1.1 1 0 0 1 1 1 0 Glycyl-tRNA synthetase alpha subunit IF2_N PF04760.15 EPA06541.1 - 0.051 13.4 0.1 0.083 12.7 0.1 1.3 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region DUF1246 PF06849.12 EPA06542.1 - 2.5e-22 79.1 0.0 2.8e-22 78.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1246) Saccharop_dh_N PF04455.12 EPA06543.1 - 6.1e-35 119.6 0.2 1.5e-34 118.4 0.2 1.7 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region TPP_enzyme_M PF00205.22 EPA06543.1 - 0.00055 19.7 1.0 0.019 14.7 0.1 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain DS PF01916.17 EPA06543.1 - 0.014 14.7 1.3 0.18 11.0 0.2 2.6 1 1 1 3 3 3 0 Deoxyhypusine synthase Citrate_bind PF16114.5 EPA06543.1 - 0.067 12.7 0.2 0.27 10.7 0.0 2.0 2 1 1 3 3 3 0 ATP citrate lyase citrate-binding Pyr_redox PF00070.27 EPA06545.1 - 0.022 15.3 0.1 0.025 15.1 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF1297 PF06973.12 EPA06546.1 - 1.5e-74 249.6 0.1 1.9e-74 249.3 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) DUF1246 PF06849.12 EPA06546.1 - 5e-14 52.3 0.0 9.8e-14 51.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1246) Arc_PepC_II PF06847.11 EPA06547.1 - 1.8e-09 38.0 0.2 1.8e-09 38.0 0.2 2.3 2 1 0 2 2 2 1 Archaeal Peptidase A24 C-terminus Type II Peptidase_A24 PF01478.18 EPA06547.1 - 7.1e-06 26.4 7.9 1.3e-05 25.5 7.9 1.5 1 0 0 1 1 1 1 Type IV leader peptidase family TrmB PF01978.19 EPA06548.1 - 4.5e-05 23.3 0.1 7.5e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 EPA06548.1 - 0.0001 22.1 0.2 0.00018 21.4 0.2 1.5 1 0 0 1 1 1 1 HTH domain HTH_20 PF12840.7 EPA06548.1 - 0.00032 20.7 0.0 0.00047 20.2 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 EPA06548.1 - 0.00043 20.1 0.1 0.00083 19.2 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_7 PF02796.15 EPA06548.1 - 0.0008 19.4 0.1 0.0017 18.4 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_IclR PF09339.10 EPA06548.1 - 0.0011 18.7 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_23 PF13384.6 EPA06548.1 - 0.0012 18.5 0.0 0.0023 17.7 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_40 PF14493.6 EPA06548.1 - 0.0018 18.7 0.1 0.0026 18.2 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Mga PF05043.13 EPA06548.1 - 0.0025 18.4 1.8 0.0072 16.9 0.4 2.0 1 1 1 2 2 2 1 Mga helix-turn-helix domain FUR PF01475.19 EPA06548.1 - 0.0042 17.2 0.0 0.0049 17.0 0.0 1.4 1 0 0 1 1 1 1 Ferric uptake regulator family DUF4423 PF14394.6 EPA06548.1 - 0.0042 16.8 0.1 0.0049 16.6 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) MarR_2 PF12802.7 EPA06548.1 - 0.0077 16.1 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 MarR family DUF1492 PF07374.11 EPA06548.1 - 0.013 15.7 0.2 0.018 15.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) Fe_dep_repress PF01325.19 EPA06548.1 - 0.019 15.1 0.1 0.031 14.5 0.1 1.4 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_24 PF13412.6 EPA06548.1 - 0.019 14.5 0.0 0.039 13.5 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_22 PF13309.6 EPA06548.1 - 0.022 14.8 0.0 0.041 14.0 0.0 1.5 1 0 0 1 1 1 0 HTH domain Sigma70_r4_2 PF08281.12 EPA06548.1 - 0.027 14.2 0.1 0.048 13.3 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_Crp_2 PF13545.6 EPA06548.1 - 0.047 13.7 0.1 0.1 12.6 0.1 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain TnsD PF15978.5 EPA06548.1 - 0.058 12.4 0.2 0.062 12.3 0.2 1.2 1 0 0 1 1 1 0 Tn7-like transposition protein D ATPase PF06745.13 EPA06549.1 - 2e-59 200.7 0.2 2.5e-59 200.4 0.2 1.0 1 0 0 1 1 1 1 KaiC GvpD PF07088.11 EPA06549.1 - 4.7e-12 45.3 0.0 6.2e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 GvpD gas vesicle protein DnaB_C PF03796.15 EPA06549.1 - 1.6e-05 24.4 0.1 7.5e-05 22.2 0.0 2.1 3 0 0 3 3 3 1 DnaB-like helicase C terminal domain AAA_25 PF13481.6 EPA06549.1 - 2.7e-05 23.9 0.0 8e-05 22.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EPA06549.1 - 0.00076 19.3 0.3 0.002 17.9 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EPA06549.1 - 0.0024 18.4 0.7 0.019 15.5 0.4 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EPA06549.1 - 0.0032 17.9 0.0 0.0045 17.4 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain RecA PF00154.21 EPA06549.1 - 0.0042 16.6 0.0 0.0087 15.5 0.0 1.5 1 0 0 1 1 1 1 recA bacterial DNA recombination protein T2SSE PF00437.20 EPA06549.1 - 0.0045 16.1 0.0 0.0084 15.2 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_11 PF13086.6 EPA06549.1 - 0.0065 16.3 0.0 0.019 14.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EPA06549.1 - 0.0069 16.7 0.1 0.017 15.4 0.0 1.9 1 1 1 2 2 2 1 AAA domain ATPase_2 PF01637.18 EPA06549.1 - 0.0079 16.1 0.0 0.016 15.2 0.0 1.4 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EPA06549.1 - 0.011 15.7 0.0 0.056 13.5 0.0 2.1 2 1 1 3 3 3 0 AAA domain IstB_IS21 PF01695.17 EPA06549.1 - 0.019 14.7 0.0 0.15 11.8 0.0 2.2 2 1 1 3 3 3 0 IstB-like ATP binding protein NACHT PF05729.12 EPA06549.1 - 0.021 14.7 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 EPA06549.1 - 0.022 14.5 0.0 0.49 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EPA06549.1 - 0.045 14.1 0.0 0.37 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EPA06549.1 - 0.051 12.8 0.0 0.08 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DAP3 PF10236.9 EPA06549.1 - 0.052 12.7 0.0 0.13 11.4 0.0 1.6 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Terminase_6 PF03237.15 EPA06549.1 - 0.052 13.2 0.0 0.12 12.0 0.0 1.9 1 1 1 2 2 2 0 Terminase-like family PPV_E1_C PF00519.17 EPA06549.1 - 0.06 12.2 0.1 5.5 5.7 0.0 2.2 2 0 0 2 2 2 0 Papillomavirus helicase AAA_33 PF13671.6 EPA06549.1 - 0.061 13.5 0.1 0.15 12.2 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EPA06549.1 - 0.097 12.2 0.0 0.28 10.7 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region Rad17 PF03215.15 EPA06549.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_5 PF07728.14 EPA06549.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) cobW PF02492.19 EPA06549.1 - 0.11 12.1 0.0 0.24 10.9 0.0 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.18 EPA06549.1 - 0.13 12.0 0.0 0.37 10.5 0.0 1.8 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase Roc PF08477.13 EPA06549.1 - 0.15 12.3 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 EPA06549.1 - 0.21 11.8 0.0 0.39 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain ACAS_N PF16177.5 EPA06550.1 - 3.1e-11 43.0 1.9 6e-11 42.1 1.9 1.5 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding PF00501.28 EPA06550.1 - 0.076 11.6 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 AMP-binding enzyme TrmB PF01978.19 EPA06551.1 - 6.4e-13 48.4 0.3 9.2e-13 47.9 0.3 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Rrf2 PF02082.20 EPA06551.1 - 0.0016 18.7 0.2 0.0062 16.9 0.1 1.8 2 0 0 2 2 2 1 Transcriptional regulator HTH_24 PF13412.6 EPA06551.1 - 0.0031 17.0 2.2 0.05 13.2 2.2 2.2 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 EPA06551.1 - 0.0062 16.6 0.0 0.0089 16.1 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_9 PF08221.11 EPA06551.1 - 0.0065 16.5 0.1 0.014 15.5 0.1 1.6 1 1 0 1 1 1 1 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_46 PF15977.5 EPA06551.1 - 0.032 14.2 1.8 0.11 12.6 0.2 2.1 1 1 1 2 2 2 0 Winged helix-turn-helix DNA binding RNA_pol_Rpb5_C PF01191.19 EPA06551.1 - 0.053 13.4 0.2 0.15 12.0 0.1 1.7 2 0 0 2 2 2 0 RNA polymerase Rpb5, C-terminal domain PadR PF03551.14 EPA06551.1 - 0.075 13.0 0.1 0.15 12.0 0.1 1.5 1 1 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_27 PF13463.6 EPA06551.1 - 0.13 12.8 0.0 0.19 12.3 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain GatB_Yqey PF02637.18 EPA06552.1 - 1.2e-29 103.1 4.1 1.4e-29 102.9 4.1 1.0 1 0 0 1 1 1 1 GatB domain ApbA_C PF08546.11 EPA06552.1 - 0.085 13.1 0.0 0.11 12.6 0.0 1.3 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal Hen1_Lam_C PF18441.1 EPA06553.1 - 0.051 13.4 0.6 2.2 8.2 0.1 2.2 1 1 0 2 2 2 0 Hen1 La-motif C-terminal domain Phi-29_GP4 PF05464.11 EPA06553.1 - 0.099 12.9 0.0 0.23 11.8 0.0 1.5 1 1 0 1 1 1 0 Phi-29-like late genes activator (early protein GP4) Hydantoinase_A PF01968.18 EPA06554.1 - 1.4e-36 126.3 1.3 2.4e-36 125.5 1.3 1.4 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase tRNA-synt_2 PF00152.20 EPA06555.1 - 1.6e-43 149.0 0.2 2e-43 148.7 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EPA06555.1 - 1.2e-11 44.5 0.0 2.1e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain TrmB PF01978.19 EPA06556.1 - 2.4e-11 43.3 0.0 4.8e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 EPA06556.1 - 0.0058 16.4 0.0 0.0099 15.7 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_9 PF08221.11 EPA06556.1 - 0.021 14.9 0.0 0.045 13.8 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain BOP1NT PF08145.12 EPA06556.1 - 0.048 13.6 0.6 0.079 12.9 0.1 1.6 2 0 0 2 2 2 0 BOP1NT (NUC169) domain TnpB_IS66 PF05717.13 EPA06556.1 - 0.078 12.9 0.2 21 5.1 0.0 2.9 3 1 1 4 4 4 0 IS66 Orf2 like protein HSBP1 PF06825.12 EPA06556.1 - 0.72 9.7 3.5 0.72 9.7 1.0 2.2 2 0 0 2 2 2 0 Heat shock factor binding protein 1 AMP-binding PF00501.28 EPA06557.1 - 5.8e-60 203.1 0.0 6.9e-60 202.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EPA06557.1 - 9.8e-17 61.7 0.0 1.7e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AFP_2 PF18815.1 EPA06557.1 - 0.53 10.6 2.1 0.58 10.4 0.1 2.1 2 0 0 2 2 2 0 Bacterial antifreeze protein repeat FTR1 PF03239.14 EPA06558.1 - 1.2e-20 73.9 20.3 3.3e-14 52.8 4.8 2.5 1 1 1 2 2 2 2 Iron permease FTR1 family DUF2228 PF10228.9 EPA06558.1 - 0.034 13.9 0.9 0.073 12.8 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) HemY_N PF07219.13 EPA06558.1 - 9.1 6.5 0.0 9.1 6.5 0.0 5.2 5 1 1 6 6 6 0 HemY protein N-terminus Amidase PF01425.21 EPA06559.1 - 4.2e-136 454.5 0.0 4.8e-136 454.3 0.0 1.0 1 0 0 1 1 1 1 Amidase Hydant_A_N PF05378.13 EPA06560.1 - 2.2e-20 73.1 6.9 5.1e-20 71.9 6.9 1.6 1 1 0 1 1 1 1 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 EPA06560.1 - 1.8e-10 40.6 0.8 2.6e-09 36.8 0.0 2.4 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase MutL PF13941.6 EPA06560.1 - 1e-05 24.4 0.7 1.3e-05 24.0 0.7 1.2 1 0 0 1 1 1 1 MutL protein FGGY_N PF00370.21 EPA06560.1 - 2.3e-05 24.1 1.3 7.8e-05 22.4 1.2 1.9 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EPA06560.1 - 3.8e-05 23.3 2.4 3.9e-05 23.3 1.3 1.4 1 1 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family ACT_6 PF13740.6 EPA06560.1 - 0.0066 16.4 0.1 0.013 15.4 0.1 1.5 1 0 0 1 1 1 1 ACT domain HisG_C PF08029.11 EPA06560.1 - 0.032 14.4 0.0 0.077 13.1 0.0 1.6 1 0 0 1 1 1 0 HisG, C-terminal domain DEDD_Tnp_IS110 PF01548.17 EPA06560.1 - 0.04 13.8 0.6 0.16 11.8 0.1 2.0 1 1 1 2 2 2 0 Transposase PUB PF09409.10 EPA06562.1 - 0.065 13.2 0.0 0.081 12.9 0.0 1.2 1 0 0 1 1 1 0 PUB domain DUF655 PF04919.12 EPA06564.1 - 6.9e-50 169.5 0.1 7.7e-50 169.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF655) HHH_6 PF14579.6 EPA06564.1 - 5.9e-05 23.3 0.0 0.00011 22.4 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_3 PF12836.7 EPA06564.1 - 0.0047 17.2 0.0 0.012 15.9 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_24 PF13412.6 EPA06565.1 - 1.6e-06 27.6 0.0 1.7e-06 27.4 0.0 1.0 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 EPA06565.1 - 7.5e-06 25.7 0.0 8.6e-06 25.5 0.0 1.0 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain Ribosomal_60s PF00428.19 EPA06566.1 - 6.4e-12 45.9 15.2 7.4e-12 45.7 15.2 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein PepSY_2 PF13670.6 EPA06566.1 - 0.066 13.2 6.2 0.24 11.4 3.1 2.1 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Oxidored_q6 PF01058.22 EPA06567.1 - 0.077 12.8 0.1 0.17 11.7 0.1 1.3 1 1 0 1 1 1 0 NADH ubiquinone oxidoreductase, 20 Kd subunit DUF2897 PF11446.8 EPA06567.1 - 2.5 8.0 4.3 5.4 7.0 4.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) Metallophos PF00149.28 EPA06568.1 - 4.1e-19 69.9 0.4 6e-19 69.4 0.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EPA06568.1 - 2e-15 57.4 0.0 2.8e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EPA06568.1 - 7e-07 28.8 0.1 0.00055 19.3 0.1 2.2 1 1 0 2 2 2 2 Metallophosphoesterase, calcineurin superfamily DUF2124 PF09897.9 EPA06568.1 - 0.005 16.7 0.0 0.0081 16.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2124) DUF1102 PF06510.11 EPA06570.1 - 0.017 15.3 1.1 0.041 14.0 1.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1102) Glyco_hydro2_C5 PF18565.1 EPA06570.1 - 0.14 12.0 0.1 0.24 11.3 0.1 1.3 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 RNA_pol_Rpb4 PF03874.16 EPA06571.1 - 7.9e-08 32.7 0.9 1.5e-07 31.8 0.9 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb4 Integrase_Zn PF02022.19 EPA06571.1 - 0.0077 16.2 0.0 2.9 7.9 0.0 2.4 2 0 0 2 2 2 2 Integrase Zinc binding domain DUF4844 PF16133.5 EPA06571.1 - 0.027 15.0 0.3 0.049 14.2 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4844) Nop PF01798.18 EPA06572.1 - 2.5e-65 220.2 0.1 3.5e-65 219.7 0.1 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Rad51 PF08423.11 EPA06573.1 - 1.2e-89 299.9 0.0 1.9e-89 299.3 0.0 1.3 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EPA06573.1 - 4.7e-11 42.7 0.1 7.8e-11 41.9 0.1 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 EPA06573.1 - 8.5e-10 39.1 0.1 3.4e-09 37.2 0.1 2.1 1 0 0 1 1 1 1 Helix-hairpin-helix domain AAA_25 PF13481.6 EPA06573.1 - 7.7e-09 35.4 0.0 1.3e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EPA06573.1 - 2.3e-07 30.4 0.1 2.3e-07 30.4 0.1 1.9 2 1 0 2 2 2 1 KaiC AAA_24 PF13479.6 EPA06573.1 - 0.0005 19.8 0.1 0.0015 18.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain DNA_pol_lambd_f PF10391.9 EPA06573.1 - 0.051 13.4 0.0 1.2 9.0 0.0 2.7 2 1 0 2 2 2 0 Fingers domain of DNA polymerase lambda NACHT PF05729.12 EPA06573.1 - 0.15 12.0 0.0 0.37 10.7 0.0 1.6 2 0 0 2 2 2 0 NACHT domain NARP1 PF12569.8 EPA06573.1 - 1.8 7.4 8.6 2.8 6.8 8.6 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 IZUMO PF15005.6 EPA06574.1 - 0.085 13.4 0.1 0.16 12.4 0.1 1.4 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Ribosomal_S30 PF04758.14 EPA06575.1 - 9.6e-11 41.7 3.2 1.5e-10 41.1 3.2 1.4 1 1 0 1 1 1 1 Ribosomal protein S30 NAD_binding_1 PF00175.21 EPA06576.1 - 2.6e-09 37.7 0.1 6.5e-09 36.4 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain DHODB_Fe-S_bind PF10418.9 EPA06576.1 - 1.7e-07 30.9 8.8 3.8e-07 29.8 8.8 1.6 1 0 0 1 1 1 1 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B FAD_binding_6 PF00970.24 EPA06576.1 - 0.002 18.4 0.0 0.0048 17.2 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EPA06576.1 - 0.6 10.2 2.9 19 5.3 0.0 2.8 3 0 0 3 3 3 0 Ferric reductase NAD binding domain HATPase_c PF02518.26 EPA06577.1 - 2.7e-17 63.3 0.2 6.1e-17 62.1 0.2 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 EPA06577.1 - 1.4e-14 54.5 11.9 1.4e-14 54.5 11.9 2.2 2 0 0 2 2 2 1 Cache domain HisKA PF00512.25 EPA06577.1 - 7.1e-11 42.0 0.0 1.6e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EPA06577.1 - 1.3e-06 28.2 1.9 2.6e-06 27.3 0.1 2.6 2 0 0 2 2 2 1 GHKL domain HAMP PF00672.25 EPA06577.1 - 0.00086 19.6 0.0 0.0025 18.2 0.0 1.9 1 0 0 1 1 1 1 HAMP domain Lip_prot_lig_C PF10437.9 EPA06577.1 - 0.02 14.9 2.0 7.1 6.7 0.1 2.9 2 0 0 2 2 2 0 Bacterial lipoate protein ligase C-terminus LMSTEN PF07988.12 EPA06577.1 - 0.09 12.3 0.0 0.26 10.8 0.0 1.8 1 0 0 1 1 1 0 LMSTEN motif UPF0126 PF03458.13 EPA06578.1 - 5.2e-38 128.8 24.9 1.4e-20 72.9 5.5 2.4 3 0 0 3 3 3 2 UPF0126 domain Ribosomal_L21e PF01157.18 EPA06579.1 - 6.3e-19 67.7 1.8 7.9e-19 67.4 1.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L21e Radical_SAM PF04055.21 EPA06580.1 - 1.2e-08 35.5 0.0 2.9e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily RL10P_insert PF17777.1 EPA06581.1 - 2e-20 72.6 0.1 4.6e-20 71.4 0.1 1.7 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EPA06581.1 - 9.1e-19 67.5 0.6 9.1e-19 67.5 0.6 2.1 2 1 0 2 2 2 1 Ribosomal protein L10 HPHLAWLY PF14925.6 EPA06581.1 - 0.1 11.2 0.7 0.17 10.5 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function DHO_dh PF01180.21 EPA06582.1 - 7e-55 186.3 1.0 8e-55 186.1 1.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Dus PF01207.17 EPA06582.1 - 3.9e-07 29.5 0.5 0.00026 20.2 0.2 2.0 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 EPA06582.1 - 1.9e-05 24.3 0.2 0.047 13.1 0.0 2.6 3 0 0 3 3 3 2 Histidine biosynthesis protein NMO PF03060.15 EPA06582.1 - 0.00015 21.3 0.4 0.0012 18.3 0.4 2.0 1 1 0 1 1 1 1 Nitronate monooxygenase DUF561 PF04481.12 EPA06582.1 - 0.00017 20.8 8.4 0.00046 19.4 0.1 3.6 3 1 0 4 4 4 1 Protein of unknown function (DUF561) G3P_antiterm PF04309.12 EPA06582.1 - 0.0011 18.4 2.5 0.82 9.1 0.2 2.7 4 0 0 4 4 4 2 Glycerol-3-phosphate responsive antiterminator ThiG PF05690.14 EPA06582.1 - 0.0013 18.1 2.4 0.2 10.9 0.7 2.7 2 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 EPA06582.1 - 0.0028 16.7 0.5 0.012 14.7 0.0 1.9 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain Antimicrobial_8 PF08103.11 EPA06582.1 - 0.082 13.1 0.0 0.27 11.4 0.0 2.0 1 0 0 1 1 1 0 Uperin family Methyltransf_31 PF13847.6 EPA06583.1 - 5.5e-09 36.0 0.3 2e-08 34.2 0.3 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA06583.1 - 3.1e-07 30.9 0.0 6e-07 30.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EPA06583.1 - 3.9e-06 26.5 0.0 1.1e-05 25.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 EPA06583.1 - 8.9e-06 25.6 0.0 3.9e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA06583.1 - 4.7e-05 24.0 0.2 0.00012 22.7 0.2 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA06583.1 - 5.2e-05 23.9 0.1 0.00013 22.6 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EPA06583.1 - 0.00038 20.3 0.0 0.001 18.8 0.0 1.7 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EPA06583.1 - 0.002 17.5 0.1 0.0028 17.0 0.1 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EPA06583.1 - 0.0033 17.4 0.0 0.0051 16.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 EPA06583.1 - 0.036 13.1 0.0 0.21 10.6 0.0 1.9 1 1 0 1 1 1 0 Ribosomal RNA adenine dimethylase PrmA PF06325.13 EPA06583.1 - 0.086 12.2 0.1 0.19 11.1 0.1 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 EPA06583.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain FMP23 PF17315.2 EPA06586.1 - 0.019 15.1 2.1 0.023 14.9 1.4 1.5 1 1 0 1 1 1 0 Found in mitochondrial proteome EIF_2_alpha PF07541.12 EPA06586.1 - 0.04 14.0 1.2 0.063 13.4 0.7 1.6 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit DivIC PF04977.15 EPA06587.1 - 0.0033 17.2 1.6 0.0046 16.7 1.6 1.4 1 1 0 1 1 1 1 Septum formation initiator CCD48 PF15799.5 EPA06587.1 - 0.035 12.4 0.1 0.035 12.4 0.1 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 NUDE_C PF04880.13 EPA06587.1 - 0.046 14.2 0.5 0.051 14.1 0.5 1.0 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region DUF1192 PF06698.11 EPA06587.1 - 0.08 13.0 2.9 0.13 12.3 2.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1192) Radical_SAM PF04055.21 EPA06588.1 - 1.9e-19 70.6 0.0 3.1e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 EPA06588.1 - 0.00032 20.8 0.0 0.00058 20.0 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 EPA06588.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S single cluster domain Iso_dh PF00180.20 EPA06590.1 - 1.6e-83 280.8 0.6 1.8e-83 280.6 0.6 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Response_reg PF00072.24 EPA06591.1 - 4.4e-24 84.8 1.2 5e-24 84.6 1.2 1.0 1 0 0 1 1 1 1 Response regulator receiver domain RrnaAD PF00398.20 EPA06592.1 - 6.2e-40 136.9 1.1 8.4e-40 136.5 1.1 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PCMT PF01135.19 EPA06592.1 - 7.7e-05 22.5 0.0 0.00015 21.6 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 EPA06592.1 - 0.0011 19.6 0.0 0.0028 18.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA06592.1 - 0.019 15.7 0.0 0.067 13.9 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain SAM_3 PF18016.1 EPA06592.1 - 0.053 13.3 0.2 7.7 6.4 0.1 2.7 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Methyltransf_32 PF13679.6 EPA06592.1 - 0.059 13.4 0.0 0.09 12.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EPA06592.1 - 0.099 12.5 0.0 0.17 11.7 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EPA06592.1 - 0.12 13.0 0.0 0.25 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Transglut_core2 PF13369.6 EPA06593.1 - 1.2e-40 138.6 0.0 1.6e-40 138.2 0.0 1.1 1 0 0 1 1 1 1 Transglutaminase-like superfamily TPR_9 PF13371.6 EPA06593.1 - 3.8e-15 55.8 0.0 5.8e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EPA06593.1 - 0.00022 21.2 0.1 0.58 10.3 0.0 2.8 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 EPA06593.1 - 0.0006 19.5 0.1 1.4 8.9 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EPA06593.1 - 0.13 12.4 0.0 26 5.3 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EPA06593.1 - 0.14 13.1 0.0 3.6 8.7 0.0 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat Methyltransf_25 PF13649.6 EPA06594.1 - 5.8e-09 36.5 0.0 9.6e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA06594.1 - 1.4e-08 34.7 0.0 2.6e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA06594.1 - 1.6e-08 35.0 0.0 2.9e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EPA06594.1 - 3.6e-08 33.4 0.0 4.9e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA06594.1 - 7.5e-08 33.0 0.0 1.8e-07 31.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 EPA06594.1 - 9.3e-07 28.2 1.2 1.4e-06 27.6 0.4 1.4 1 1 1 2 2 2 1 DREV methyltransferase Trm112p PF03966.16 EPA06594.1 - 0.00033 21.1 0.8 0.003 18.1 0.5 2.7 3 1 0 3 3 3 1 Trm112p-like protein TehB PF03848.14 EPA06594.1 - 0.0015 18.0 0.2 0.0023 17.3 0.2 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB NodS PF05401.11 EPA06594.1 - 0.0015 18.2 0.0 0.0042 16.7 0.0 1.6 1 1 1 2 2 2 1 Nodulation protein S (NodS) MTS PF05175.14 EPA06594.1 - 0.002 17.7 0.0 0.0058 16.2 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase small domain zf-CSL PF05207.13 EPA06594.1 - 0.0074 16.0 0.9 0.017 14.9 0.9 1.6 1 0 0 1 1 1 1 CSL zinc finger Ribosomal_L1 PF00687.21 EPA06596.1 - 4.2e-38 131.1 1.8 5.4e-38 130.8 1.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family PhnA_Zn_Ribbon PF08274.12 EPA06599.1 - 0.039 13.9 1.1 1.9 8.5 0.1 2.1 2 0 0 2 2 2 0 PhnA Zinc-Ribbon OrfB_Zn_ribbon PF07282.11 EPA06599.1 - 0.04 13.8 0.3 0.043 13.8 0.3 1.1 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-RING_4 PF14570.6 EPA06599.1 - 0.067 13.0 3.4 3.8 7.4 0.1 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DUF4451 PF14616.6 EPA06599.1 - 0.14 12.4 0.8 0.3 11.3 0.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4451) AMMECR1 PF01871.17 EPA06600.1 - 7.6e-20 71.2 0.0 8.3e-20 71.1 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 DUF126 PF01989.16 EPA06601.1 - 0.0038 17.0 0.1 0.0054 16.5 0.1 1.3 1 0 0 1 1 1 1 Aconitase X swivel domain DUF126 PF01989.16 EPA06602.1 - 8.8e-06 25.4 0.0 1.5e-05 24.7 0.0 1.4 2 0 0 2 2 2 1 Aconitase X swivel domain E1-E2_ATPase PF00122.20 EPA06603.1 - 2.3e-48 164.1 0.8 3e-48 163.7 0.8 1.2 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EPA06603.1 - 3.1e-06 27.6 0.0 6.5e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase ABC_membrane PF00664.23 EPA06603.1 - 0.03 14.0 0.6 0.049 13.3 0.6 1.3 1 0 0 1 1 1 0 ABC transporter transmembrane region DUF1402 PF07182.11 EPA06603.1 - 0.084 11.9 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1402) E1-E2_ATPase PF00122.20 EPA06604.1 - 2.3e-48 164.1 0.8 3e-48 163.7 0.8 1.2 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EPA06604.1 - 2.2e-06 28.1 0.0 4.7e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase ABC_membrane PF00664.23 EPA06604.1 - 0.03 14.0 0.6 0.049 13.3 0.6 1.3 1 0 0 1 1 1 0 ABC transporter transmembrane region DUF1402 PF07182.11 EPA06604.1 - 0.084 11.9 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1402) C5-epim_C PF06662.13 EPA06605.1 - 4e-10 39.5 2.3 0.059 12.9 0.0 3.8 4 0 0 4 4 4 3 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_88 PF07470.13 EPA06605.1 - 8.6e-08 31.6 0.1 0.29 10.2 0.0 3.8 2 2 2 4 4 4 3 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 EPA06605.1 - 3.3e-05 22.6 0.4 0.15 10.6 0.0 3.2 2 1 1 3 3 3 2 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_76 PF03663.14 EPA06605.1 - 8.9e-05 22.2 0.0 0.43 10.0 0.0 3.3 2 1 1 3 3 3 2 Glycosyl hydrolase family 76 GlcNAc_2-epim PF07221.11 EPA06605.1 - 0.00037 19.9 0.1 3.7 6.7 0.0 3.7 2 1 2 4 4 4 2 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) LANC_like PF05147.13 EPA06605.1 - 0.0079 14.8 0.4 5.6 5.4 0.1 3.6 3 1 1 4 4 4 2 Lanthionine synthetase C-like protein Pec_lyase PF09492.10 EPA06605.1 - 0.027 13.8 0.3 7.8 5.7 0.1 2.7 3 0 0 3 3 3 0 Pectic acid lyase Pox_RNA_Pol_22 PF05273.13 EPA06606.1 - 0.14 11.9 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Poxvirus RNA polymerase 22 kDa subunit Na_H_Exchanger PF00999.21 EPA06607.1 - 7e-51 173.2 54.8 8.7e-51 172.9 54.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family CBS PF00571.28 EPA06607.1 - 1.1e-12 48.2 1.0 5.7e-06 26.7 0.1 2.7 2 0 0 2 2 2 2 CBS domain PP_kinase_N PF13089.6 EPA06609.1 - 0.001 19.4 0.5 0.0011 19.3 0.5 1.0 1 0 0 1 1 1 1 Polyphosphate kinase N-terminal domain LPD25 PF18840.1 EPA06609.1 - 0.028 15.0 0.3 0.031 14.8 0.3 1.1 1 0 0 1 1 1 0 Large polyvalent protein associated domain 25 Phage_HK97_TLTM PF06120.11 EPA06611.1 - 0.00015 21.1 0.8 0.00018 20.8 0.8 1.1 1 0 0 1 1 1 1 Tail length tape measure protein WXG100 PF06013.12 EPA06611.1 - 0.0011 19.2 0.7 0.002 18.3 0.7 1.4 1 0 0 1 1 1 1 Proteins of 100 residues with WXG MAS20 PF02064.15 EPA06611.1 - 0.019 15.1 0.1 0.035 14.2 0.1 1.4 1 0 0 1 1 1 0 MAS20 protein import receptor WEMBL PF05701.11 EPA06611.1 - 0.027 13.2 2.9 0.034 12.8 2.9 1.0 1 0 0 1 1 1 0 Weak chloroplast movement under blue light SLATT_6 PF18169.1 EPA06611.1 - 0.04 13.5 0.6 0.049 13.2 0.6 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 ETRAMP PF09716.10 EPA06611.1 - 0.091 12.8 0.9 0.091 12.8 0.9 1.8 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) PRKG1_interact PF15898.5 EPA06611.1 - 0.48 11.4 4.1 0.92 10.4 3.8 1.8 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain EamA PF00892.20 EPA06612.1 - 0.00086 19.5 0.9 0.00086 19.5 0.9 1.0 1 0 0 1 1 1 1 EamA-like transporter family Arcadin_1 PF18653.1 EPA06613.1 - 0.003 17.6 0.9 0.0039 17.2 0.9 1.2 1 0 0 1 1 1 1 Arcadin 1 Usp PF00582.26 EPA06614.1 - 4.8e-08 33.6 0.0 5e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family DUF1400 PF07176.11 EPA06614.1 - 0.039 14.2 0.0 0.044 14.1 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1400) Thioredox_DsbH PF03190.15 EPA06615.1 - 3.1e-77 258.1 0.1 3.6e-77 257.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 EPA06615.1 - 2.5e-11 43.6 0.3 4.5e-11 42.8 0.1 1.6 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EPA06615.1 - 0.0064 16.9 0.2 0.012 16.1 0.0 1.5 2 0 0 2 2 2 1 Thioredoxin-like domain DUF2193 PF09959.9 EPA06615.1 - 0.11 10.9 0.0 0.18 10.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2193) TruD PF01142.18 EPA06616.1 - 7.3e-45 153.5 0.1 8.3e-45 153.3 0.1 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) DnaJ_CXXCXGXG PF00684.19 EPA06617.1 - 0.014 15.7 2.3 0.017 15.5 2.3 1.2 1 0 0 1 1 1 0 DnaJ central domain PADR1 PF08063.12 EPA06617.1 - 0.014 15.1 0.4 0.014 15.1 0.4 1.8 1 1 1 2 2 2 0 PADR1 (NUC008) domain DUF5351 PF17302.2 EPA06617.1 - 0.66 10.2 5.0 3.9 7.7 5.0 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5351) Helicase_C_2 PF13307.6 EPA06620.1 - 7.1e-20 71.9 0.1 2.4e-19 70.2 0.0 1.9 2 1 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EPA06620.1 - 7.2e-06 25.7 0.5 2.1e-05 24.2 0.2 1.9 2 0 0 2 2 2 1 DEAD_2 GIY-YIG PF01541.24 EPA06622.1 - 7.9e-06 26.1 0.2 1e-05 25.7 0.2 1.3 1 1 0 1 1 1 1 GIY-YIG catalytic domain PP_kinase_C PF13090.6 EPA06622.1 - 0.027 13.9 0.0 0.031 13.8 0.0 1.1 1 0 0 1 1 1 0 Polyphosphate kinase C-terminal domain 2 Endonuc-HincII PF09226.11 EPA06622.1 - 0.054 12.8 0.1 0.061 12.6 0.1 1.0 1 0 0 1 1 1 0 Restriction endonuclease HincII Tubulin PF00091.25 EPA06623.1 - 1.3e-09 38.5 0.0 1.6e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Whirly PF08536.11 EPA06623.1 - 0.091 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Whirly transcription factor MtN3_slv PF03083.16 EPA06624.1 - 5e-08 32.9 3.3 5.7e-08 32.7 3.3 1.1 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange PQ-loop PF04193.14 EPA06624.1 - 0.00012 21.8 4.1 0.00012 21.8 4.1 1.5 2 0 0 2 2 2 1 PQ loop repeat DUF4389 PF14333.6 EPA06624.1 - 0.0084 16.0 3.1 0.88 9.5 0.9 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4389) DUF3784 PF12650.7 EPA06624.1 - 0.012 15.8 13.9 0.15 12.3 13.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3784) LAB_N PF07578.11 EPA06624.1 - 0.075 13.1 2.9 0.1 12.7 2.9 1.3 1 0 0 1 1 1 0 Lipid A Biosynthesis N-terminal domain Imp-YgjV PF10688.9 EPA06624.1 - 0.56 10.0 9.4 1 9.2 9.4 1.6 1 1 0 1 1 1 0 Bacterial inner membrane protein dCMP_cyt_deam_1 PF00383.23 EPA06625.1 - 2.8e-26 91.3 1.3 3.9e-26 90.9 1.3 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EPA06625.1 - 3.1e-14 52.9 0.2 4.2e-14 52.5 0.2 1.1 1 0 0 1 1 1 1 MafB19-like deaminase PEP-utilizers_C PF02896.18 EPA06626.1 - 1.6e-84 283.5 0.6 2.7e-84 282.8 0.6 1.4 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.19 EPA06626.1 - 9.1e-58 196.1 0.1 1e-42 146.6 0.0 3.7 2 1 1 3 3 3 2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers PF00391.23 EPA06626.1 - 2.4e-26 91.3 0.2 5.6e-26 90.1 0.2 1.7 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain Snf7 PF03357.21 EPA06627.1 - 1.8e-06 27.7 0.0 2.4e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Snf7 Proteasom_PSMB PF10508.9 EPA06627.1 - 7.2e-05 21.5 1.2 0.0001 21.0 1.2 1.2 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit DASH_Dam1 PF08653.10 EPA06627.1 - 0.0021 17.8 1.8 7.9 6.4 0.2 3.9 2 1 2 4 4 4 2 DASH complex subunit Dam1 Phage_int_SAM_2 PF12834.7 EPA06627.1 - 0.096 13.4 1.1 1.1 10.0 0.4 2.3 1 1 1 2 2 2 0 Phage integrase, N-terminal Abhydrolase_4 PF08386.10 EPA06628.1 - 0.18 11.9 0.0 0.23 11.6 0.0 1.2 1 0 0 1 1 1 0 TAP-like protein zf-CDGSH PF09360.10 EPA06629.1 - 3.3e-11 43.2 1.2 4.3e-11 42.9 1.2 1.2 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type DNA_pol_B PF00136.21 EPA06630.1 - 7.7e-45 153.4 1.8 1.5e-44 152.5 1.8 1.4 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EPA06630.1 - 2.1e-37 129.0 3.0 3.4e-37 128.3 3.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain RNase_H_2 PF13482.6 EPA06630.1 - 1.3e-06 28.5 4.0 1.7e-06 28.2 2.0 2.1 2 1 0 2 2 2 1 RNase_H superfamily DNA_pol_B_exo2 PF10108.9 EPA06630.1 - 1.7e-05 24.6 1.7 0.00011 22.0 1.7 2.2 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB SpoVIF PF14069.6 EPA06630.1 - 0.033 14.0 0.5 0.15 11.8 0.0 2.3 2 0 0 2 2 2 0 Stage VI sporulation protein F CNP1 PF08750.11 EPA06630.1 - 0.11 12.5 0.3 0.28 11.1 0.0 1.8 2 0 0 2 2 2 0 CNP1-like family zf-C2H2_4 PF13894.6 EPA06631.1 - 0.00021 21.8 0.3 0.00041 21.0 0.3 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger DUF2688 PF10892.8 EPA06631.1 - 0.0022 17.4 0.1 0.0025 17.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2688) zf-C2H2 PF00096.26 EPA06631.1 - 0.0025 18.2 0.5 0.0043 17.4 0.5 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 EPA06631.1 - 0.0048 16.6 0.2 0.0097 15.6 0.2 1.5 1 0 0 1 1 1 1 zinc-finger C2H2-type zf-BED PF02892.15 EPA06631.1 - 0.0091 16.0 0.1 0.012 15.6 0.1 1.3 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_3 PF13878.6 EPA06631.1 - 0.01 15.6 0.5 0.014 15.2 0.0 1.5 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO zf-C2H2_2 PF12756.7 EPA06631.1 - 0.017 15.5 1.8 0.018 15.4 1.8 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.6 EPA06631.1 - 0.029 14.8 4.8 0.36 11.3 0.7 2.2 2 0 0 2 2 2 0 Zinc-finger double domain DUF629 PF04780.12 EPA06631.1 - 0.041 12.4 1.1 0.038 12.5 1.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) Actin_micro PF17003.5 EPA06631.1 - 0.082 12.1 2.4 0.078 12.1 2.4 1.0 1 0 0 1 1 1 0 Putative actin-like family YolD PF08863.10 EPA06632.1 - 0.049 13.7 3.6 5.9 7.0 1.0 2.5 2 1 0 2 2 2 0 YolD-like protein Glyoxalase PF00903.25 EPA06633.1 - 1.8e-07 31.4 0.0 2.9e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EPA06633.1 - 2.1e-05 25.3 0.0 3.3e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain TIM PF00121.18 EPA06635.1 - 5.1e-10 39.1 4.6 1.4e-09 37.7 0.4 2.0 1 1 1 2 2 2 1 Triosephosphate isomerase ThiG PF05690.14 EPA06635.1 - 2.2e-05 23.9 0.1 3.5e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG FMN_dh PF01070.18 EPA06635.1 - 0.00014 21.0 0.0 0.00025 20.2 0.0 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IGPS PF00218.21 EPA06635.1 - 0.0072 15.5 0.1 0.016 14.3 0.1 1.6 1 1 0 1 1 1 1 Indole-3-glycerol phosphate synthase NMO PF03060.15 EPA06635.1 - 0.029 13.8 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase POC1 PF10450.9 EPA06635.1 - 0.034 13.1 0.2 0.082 11.9 0.1 1.6 1 1 0 1 1 1 0 POC1 chaperone Glu_synthase PF01645.17 EPA06635.1 - 0.064 12.4 2.2 0.47 9.5 2.2 2.1 1 1 0 1 1 1 0 Conserved region in glutamate synthase GARS_A PF01071.19 EPA06636.1 - 8e-79 263.9 0.2 1.1e-78 263.5 0.2 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 EPA06636.1 - 5.8e-33 113.5 0.0 1.4e-32 112.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 EPA06636.1 - 3.8e-28 97.6 0.0 7.9e-28 96.6 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp PF02222.22 EPA06636.1 - 1.1e-07 31.5 0.0 1.9e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_2 PF08442.10 EPA06636.1 - 5.7e-07 29.3 0.1 9.7e-07 28.5 0.1 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EPA06636.1 - 5.3e-06 26.6 0.0 1.1e-05 25.5 0.0 1.6 1 1 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EPA06636.1 - 6.2e-05 22.6 0.1 0.00027 20.5 0.1 2.1 2 1 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 EPA06636.1 - 0.00031 20.3 0.0 0.00046 19.8 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus RimK PF08443.11 EPA06636.1 - 0.00036 20.2 0.0 0.0011 18.5 0.0 1.8 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATPgrasp_ST PF14397.6 EPA06636.1 - 0.0016 17.7 0.1 0.022 14.0 0.1 2.3 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp ATP-grasp_4 PF13535.6 EPA06636.1 - 0.0058 16.2 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Phage_TAC_9 PF10876.8 EPA06636.1 - 0.028 14.5 0.2 0.068 13.3 0.1 1.7 2 0 0 2 2 1 0 Phage tail assemb.y chaperone protein, TAC ATP-grasp_5 PF13549.6 EPA06636.1 - 0.031 13.7 0.0 0.061 12.8 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain SR1P PF13790.6 EPA06636.1 - 0.078 13.1 0.1 0.19 11.9 0.1 1.7 1 0 0 1 1 1 0 SR1 protein ATP-grasp_2 PF08442.10 EPA06637.1 - 7.9e-46 156.2 1.0 1.4e-45 155.3 1.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 EPA06637.1 - 2e-15 56.9 1.5 2.5e-15 56.6 0.3 1.8 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.6 EPA06637.1 - 1.3e-13 50.9 0.1 4.4e-13 49.2 0.1 1.8 1 1 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EPA06637.1 - 1.6e-05 24.5 0.0 2.8e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.22 EPA06637.1 - 0.03 13.9 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain DUF4152 PF13680.6 EPA06637.1 - 0.087 12.2 1.2 0.94 8.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4152) ABM PF03992.16 EPA06638.1 - 2e-06 27.8 0.0 2.9e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF1330 PF07045.11 EPA06638.1 - 0.021 15.2 0.0 0.03 14.7 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1330) THF_DHG_CYH_C PF02882.19 EPA06640.1 - 1.1e-58 197.1 1.0 1.7e-58 196.5 1.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EPA06640.1 - 8.9e-39 132.4 0.7 8.9e-39 132.4 0.7 1.6 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AlaDh_PNT_C PF01262.21 EPA06640.1 - 0.0016 17.8 1.1 0.0018 17.6 0.1 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Hydrolase PF00702.26 EPA06640.1 - 0.0059 16.9 0.1 0.011 16.0 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF1884 PF08967.10 EPA06640.1 - 0.084 13.1 0.1 0.28 11.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1884) Semialdhyde_dh PF01118.24 EPA06640.1 - 0.13 12.7 0.0 0.25 11.8 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EPA06640.1 - 0.18 12.1 2.0 0.32 11.2 0.1 2.3 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain PH_18 PF18469.1 EPA06641.1 - 0.0018 18.2 0.5 0.0064 16.5 0.5 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain DeoC PF01791.9 EPA06641.1 - 0.035 13.7 0.0 0.04 13.5 0.0 1.0 1 0 0 1 1 1 0 DeoC/LacD family aldolase tRNA_bind PF01588.20 EPA06641.1 - 0.05 13.7 0.0 0.063 13.4 0.0 1.2 1 0 0 1 1 1 0 Putative tRNA binding domain 5-FTHF_cyc-lig PF01812.20 EPA06643.1 - 1.9e-39 135.5 0.0 2.1e-39 135.3 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Ferritin PF00210.24 EPA06644.1 - 2.7e-21 76.0 0.0 3.8e-21 75.5 0.0 1.2 1 0 0 1 1 1 1 Ferritin-like domain Cupin_2 PF07883.11 EPA06645.1 - 4.7e-09 35.8 0.0 5e-09 35.7 0.0 1.0 1 0 0 1 1 1 1 Cupin domain CENP-C_C PF11699.8 EPA06645.1 - 9.6e-06 25.7 0.0 1e-05 25.6 0.0 1.0 1 0 0 1 1 1 1 Mif2/CENP-C like AraC_binding PF02311.19 EPA06645.1 - 0.001 19.0 0.0 0.0011 18.9 0.0 1.1 1 0 0 1 1 1 1 AraC-like ligand binding domain 3-HAO PF06052.12 EPA06645.1 - 0.014 15.1 0.1 0.019 14.6 0.1 1.3 1 1 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase Ectoine_synth PF06339.12 EPA06645.1 - 0.026 14.7 0.0 0.03 14.5 0.0 1.1 1 0 0 1 1 1 0 Ectoine synthase Pirin_C PF05726.13 EPA06645.1 - 0.037 14.4 0.0 0.045 14.1 0.0 1.0 1 0 0 1 1 1 0 Pirin C-terminal cupin domain Auxin_BP PF02041.16 EPA06645.1 - 0.094 12.4 0.0 0.098 12.3 0.0 1.2 1 0 0 1 1 1 0 Auxin binding protein tRNA-synt_1 PF00133.22 EPA06646.1 - 1.6e-137 459.3 0.2 2.4e-137 458.8 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EPA06646.1 - 8e-32 110.3 1.0 2.1e-31 109.0 1.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EPA06646.1 - 8.9e-25 87.3 0.1 1.4e-10 40.5 0.0 3.7 4 0 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EPA06646.1 - 4.4e-06 26.3 0.0 0.00013 21.4 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EPA06646.1 - 0.00087 18.3 0.4 0.0044 16.0 0.0 2.4 3 0 0 3 3 3 1 tRNA synthetases class I (K) POTRA PF07244.15 EPA06646.1 - 0.068 13.8 1.1 0.91 10.1 0.1 3.0 2 0 0 2 2 2 0 Surface antigen variable number repeat DUF4438 PF14505.6 EPA06646.1 - 0.21 10.5 0.0 0.4 9.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4438) UL11 PF11094.8 EPA06646.1 - 2.6 8.0 4.6 1.1 9.2 1.1 2.3 2 0 0 2 2 2 0 Membrane-associated tegument protein CoA_binding PF02629.19 EPA06647.1 - 2.8e-22 79.2 2.4 5.1e-22 78.4 1.3 2.0 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EPA06647.1 - 1.2e-08 34.9 0.2 2.1e-08 34.1 0.2 1.4 1 0 0 1 1 1 1 CoA-ligase CoA_binding_2 PF13380.6 EPA06647.1 - 1.2e-05 25.7 0.0 2.1e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 CoA binding domain Succ_CoA_lig PF13607.6 EPA06647.1 - 7.3e-05 22.6 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain GFO_IDH_MocA PF01408.22 EPA06647.1 - 0.013 16.3 0.1 0.023 15.5 0.1 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Ribul_P_3_epim PF00834.19 EPA06647.1 - 0.045 13.1 0.1 0.075 12.4 0.1 1.3 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Formyl_trans_N PF00551.19 EPA06648.1 - 9.8e-53 178.6 0.0 1.1e-52 178.4 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase DUF521 PF04412.13 EPA06649.1 - 3.4e-65 220.3 0.0 3.9e-65 220.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF521) DNA_RNApol_7kD PF03604.13 EPA06650.1 - 0.0024 17.5 2.2 0.0057 16.3 2.2 1.6 1 1 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit GTP_EFTU PF00009.27 EPA06651.1 - 7.6e-46 156.1 0.1 9.8e-46 155.7 0.1 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EPA06651.1 - 2.6e-37 127.5 0.2 6.2e-37 126.3 0.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EPA06651.1 - 8.6e-16 58.1 1.2 3e-15 56.3 1.2 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EPA06651.1 - 1e-05 25.4 1.1 2.3e-05 24.2 1.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 NIF3 PF01784.18 EPA06651.1 - 0.084 12.5 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 NIF3 (NGG1p interacting factor 3) FBPase_3 PF01950.16 EPA06652.1 - 1.2e-144 482.0 0.1 1.3e-144 481.8 0.1 1.0 1 0 0 1 1 1 1 Fructose-1,6-bisphosphatase Ribosomal_S10 PF00338.22 EPA06653.1 - 6.1e-23 80.9 0.0 6.8e-23 80.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e CTX_RstB PF07459.11 EPA06653.1 - 0.032 14.4 0.0 0.045 14.0 0.0 1.2 1 0 0 1 1 1 0 CTX phage RstB protein MAF_flag10 PF01973.18 EPA06654.1 - 4.5e-25 88.3 0.4 6.1e-25 87.9 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF115 TPK_catalytic PF04263.16 EPA06654.1 - 0.057 13.5 0.1 0.1 12.7 0.1 1.6 1 1 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain HATPase_c PF02518.26 EPA06656.1 - 1.9e-19 70.3 0.4 1.9e-19 70.3 0.4 2.4 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EPA06656.1 - 8.6e-08 32.1 0.0 2.9e-07 30.4 0.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EPA06656.1 - 2.7e-05 24.0 0.2 2.7e-05 24.0 0.2 2.7 2 1 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 EPA06656.1 - 2.8e-05 23.9 0.9 8.3e-05 22.4 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_L3 PF00297.22 EPA06656.1 - 0.035 13.1 3.3 0.057 12.4 3.3 1.3 1 0 0 1 1 1 0 Ribosomal protein L3 BSD PF03909.17 EPA06656.1 - 0.045 13.8 0.3 0.16 12.0 0.3 2.1 1 1 0 1 1 1 0 BSD domain Uteroglobin PF01099.17 EPA06656.1 - 0.083 13.2 0.7 0.38 11.1 0.6 2.2 1 1 0 1 1 1 0 Uteroglobin family HATPase_c_2 PF13581.6 EPA06656.1 - 0.09 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Scm3 PF10384.9 EPA06656.1 - 0.13 12.0 1.6 0.66 9.8 0.1 2.7 2 1 0 2 2 2 0 Centromere protein Scm3 Atg14 PF10186.9 EPA06656.1 - 0.18 10.9 15.2 0.26 10.3 15.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2252 PF10009.9 EPA06656.1 - 0.84 8.6 4.4 1.9 7.4 4.4 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) Iron_permease PF04120.12 EPA06657.1 - 0.00041 20.1 1.3 0.00044 20.0 1.3 1.0 1 0 0 1 1 1 1 Low affinity iron permease Spc7 PF08317.11 EPA06657.1 - 0.021 13.7 1.1 0.022 13.7 1.1 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein DASH_Dad4 PF08650.10 EPA06657.1 - 0.026 14.5 0.4 0.029 14.3 0.4 1.1 1 0 0 1 1 1 0 DASH complex subunit Dad4 PspB PF06667.12 EPA06657.1 - 0.036 14.1 0.5 0.054 13.6 0.4 1.4 1 1 0 1 1 1 0 Phage shock protein B OmpH PF03938.14 EPA06657.1 - 0.039 14.3 0.9 0.043 14.1 0.9 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HHH_2 PF12826.7 EPA06657.1 - 0.1 12.7 0.2 0.35 11.0 0.2 1.8 1 1 0 1 1 1 0 Helix-hairpin-helix motif DUF3378 PF11858.8 EPA06657.1 - 0.1 12.7 0.5 0.13 12.4 0.1 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3378) HATPase_c PF02518.26 EPA06658.1 - 2.3e-21 76.4 0.3 4.9e-21 75.3 0.3 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EPA06658.1 - 1.6e-11 44.1 0.0 3.7e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EPA06658.1 - 8.8e-07 28.8 1.8 1.4e-06 28.1 0.3 2.1 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 EPA06658.1 - 0.00027 20.8 0.0 0.00095 19.0 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EPA06658.1 - 0.021 14.8 0.0 0.044 13.7 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain CHASE3 PF05227.13 EPA06658.1 - 0.041 13.8 0.1 0.068 13.1 0.1 1.3 1 0 0 1 1 1 0 CHASE3 domain bPH_5 PF10882.8 EPA06658.1 - 0.046 13.8 0.4 1.3 9.1 0.1 2.7 2 1 0 2 2 2 0 Bacterial PH domain DUF4064 PF13273.6 EPA06658.1 - 0.33 11.3 4.7 1.1 9.6 4.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) Kinesin_assoc PF16183.5 EPA06659.1 - 0.0091 16.2 0.5 0.0091 16.2 0.5 2.0 2 0 0 2 2 2 1 Kinesin-associated DUF4070 PF13282.6 EPA06659.1 - 0.031 14.4 0.3 0.065 13.4 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4070) F420_ligase PF01996.16 EPA06660.1 - 2.6e-13 49.9 0.2 3.1e-13 49.7 0.2 1.0 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase DUF3906 PF13046.6 EPA06660.1 - 0.036 14.1 0.3 0.098 12.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3906) SelB-wing_2 PF09106.11 EPA06660.1 - 0.16 12.2 0.1 0.27 11.5 0.1 1.3 1 0 0 1 1 1 0 Elongation factor SelB, winged helix Cyclase PF04199.13 EPA06660.1 - 0.18 12.1 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative cyclase AAA_23 PF13476.6 EPA06661.1 - 0.01 16.4 0.1 0.011 16.3 0.1 1.0 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EPA06661.1 - 0.01 16.3 0.1 0.012 16.1 0.1 1.1 1 0 0 1 1 1 0 ABC transporter UvrB_inter PF17757.1 EPA06662.1 - 1.6e-28 98.7 1.2 7.3e-28 96.6 0.6 2.4 2 0 0 2 2 2 1 UvrB interaction domain UvrB PF12344.8 EPA06662.1 - 9.8e-23 79.7 4.1 2.8e-22 78.3 4.1 1.9 1 0 0 1 1 1 1 Ultra-violet resistance protein B Helicase_C PF00271.31 EPA06662.1 - 8e-19 68.0 1.1 2.3e-18 66.6 0.2 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain UVR PF02151.19 EPA06662.1 - 1.1e-09 37.8 4.5 1.1e-09 37.8 4.5 2.7 2 0 0 2 2 2 1 UvrB/uvrC motif ResIII PF04851.15 EPA06662.1 - 1.6e-07 31.5 0.0 1.6e-07 31.5 0.0 3.0 3 1 1 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EPA06662.1 - 3.5e-07 30.2 0.2 0.00029 20.7 0.1 3.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_30 PF13604.6 EPA06662.1 - 0.00067 19.4 0.0 0.037 13.8 0.0 2.8 3 0 0 3 3 3 1 AAA domain Met_synt_B12 PF02965.17 EPA06662.1 - 0.025 14.1 0.3 0.11 12.0 0.2 2.0 2 0 0 2 2 2 0 Vitamin B12 dependent methionine synthase, activation domain Rhomboid_N PF12122.8 EPA06662.1 - 0.036 14.2 0.0 8.5 6.6 0.0 2.6 2 0 0 2 2 2 0 Cytoplasmic N-terminal domain of rhomboid serine protease AAA_22 PF13401.6 EPA06662.1 - 0.045 14.0 0.9 0.95 9.7 0.0 3.1 3 1 0 3 3 3 0 AAA domain MEDS PF14417.6 EPA06662.1 - 0.19 11.6 0.6 1.2 9.0 0.1 2.5 2 0 0 2 2 2 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain AAA_19 PF13245.6 EPA06662.1 - 0.56 10.5 5.1 14 6.0 0.3 2.9 3 1 0 3 3 2 0 AAA domain Tup_N PF08581.10 EPA06662.1 - 0.63 10.4 11.3 3.4 8.0 0.0 4.0 3 0 0 3 3 3 0 Tup N-terminal ABC_tran PF00005.27 EPA06662.1 - 0.87 10.1 3.8 5.1 7.6 0.0 2.8 3 0 0 3 3 2 0 ABC transporter TPR_1 PF00515.28 EPA06663.1 - 9.4e-06 25.2 1.2 0.0037 17.0 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EPA06663.1 - 1.1e-05 25.0 0.2 1.5e-05 24.6 0.2 1.1 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.17 EPA06663.1 - 7.8e-05 22.5 0.1 0.0019 18.1 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EPA06663.1 - 0.00021 21.9 0.0 0.00026 21.6 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 EPA06663.1 - 0.00074 20.0 0.0 0.001 19.5 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 EPA06663.1 - 0.00075 19.7 1.9 0.0023 18.2 0.2 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EPA06663.1 - 0.0026 18.3 0.1 0.044 14.4 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EPA06663.1 - 0.0035 18.0 0.0 0.0041 17.7 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EPA06663.1 - 0.0053 16.9 0.0 0.0056 16.9 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EPA06663.1 - 0.0056 16.8 0.4 0.35 11.2 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat HATPase_c PF02518.26 EPA06665.1 - 8.1e-18 65.0 0.0 1.7e-17 64.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF PF01590.26 EPA06665.1 - 7.2e-08 33.1 0.0 1.2e-07 32.4 0.0 1.4 1 0 0 1 1 1 1 GAF domain HisKA PF00512.25 EPA06665.1 - 1.3e-06 28.3 1.4 2.5e-06 27.4 0.1 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 EPA06665.1 - 4.6e-05 23.7 0.0 8.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 GAF domain HATPase_c_5 PF14501.6 EPA06665.1 - 0.00044 20.1 0.2 0.0031 17.4 0.0 2.2 2 0 0 2 2 2 1 GHKL domain GAF_3 PF13492.6 EPA06665.1 - 0.0045 17.3 0.0 0.0098 16.2 0.0 1.6 1 0 0 1 1 1 1 GAF domain HATPase_c_3 PF13589.6 EPA06665.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAS PF13851.6 EPA06665.1 - 0.15 11.4 14.0 0.16 11.3 0.1 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF2703 PF10865.8 EPA06665.1 - 0.79 9.9 2.9 1.3 9.2 1.5 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF2703) TFIIB PF00382.19 EPA06666.1 - 1.7e-12 47.2 0.0 5.3e-12 45.6 0.0 1.7 2 0 0 2 2 2 1 Transcription factor TFIIB repeat RB_B PF01857.20 EPA06666.1 - 0.038 14.0 0.1 0.051 13.6 0.1 1.2 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain TF_Zn_Ribbon PF08271.12 EPA06667.1 - 7e-05 22.3 0.5 8.6e-05 22.0 0.5 1.1 1 0 0 1 1 1 1 TFIIB zinc-binding Ribosomal_S27e PF01667.17 EPA06667.1 - 0.017 14.8 0.1 0.02 14.6 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein S27 zf-ISL3 PF14690.6 EPA06667.1 - 0.087 13.5 0.0 0.14 12.9 0.0 1.3 1 0 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 MAP PF03642.13 EPA06669.1 - 0.0062 16.8 1.5 0.04 14.2 1.5 2.1 1 1 0 1 1 1 1 MAP domain Auxin_BP PF02041.16 EPA06669.1 - 0.0081 15.8 0.0 0.0092 15.7 0.0 1.2 1 0 0 1 1 1 1 Auxin binding protein Cupin_2 PF07883.11 EPA06669.1 - 0.022 14.4 0.1 0.035 13.8 0.1 1.3 1 0 0 1 1 1 0 Cupin domain TPR_2 PF07719.17 EPA06670.1 - 1.1e-27 93.8 7.8 0.00016 21.5 0.0 6.1 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 EPA06670.1 - 7.9e-26 88.8 15.1 2.5e-06 27.0 0.0 6.1 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 EPA06670.1 - 3.1e-20 71.6 4.3 0.0013 18.4 0.0 5.8 2 1 4 6 6 6 4 TPR repeat TPR_17 PF13431.6 EPA06670.1 - 1.5e-18 65.8 7.5 5.8e-05 23.2 0.2 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 EPA06670.1 - 2.8e-16 59.6 0.5 9.1e-06 25.9 0.0 3.9 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EPA06670.1 - 3e-16 58.2 11.8 3.7e-05 23.6 0.0 6.1 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 EPA06670.1 - 2.9e-15 55.8 0.1 0.064 13.9 0.0 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 EPA06670.1 - 3.7e-15 56.2 0.3 0.00047 20.6 0.0 3.5 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.6 EPA06670.1 - 2.2e-14 53.8 0.0 5e-05 23.9 0.0 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EPA06670.1 - 8.2e-14 51.1 0.0 0.25 12.3 0.0 6.1 1 1 5 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EPA06670.1 - 1.1e-11 44.7 3.7 1.5e-06 28.3 0.8 2.6 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EPA06670.1 - 1.1e-10 41.0 3.1 0.06 13.2 0.8 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 EPA06670.1 - 1.9e-08 34.3 0.0 0.0033 17.5 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EPA06670.1 - 9.3e-08 31.6 0.0 0.11 12.6 0.0 5.2 5 1 1 6 6 6 1 Tetratricopeptide repeat MIT PF04212.18 EPA06670.1 - 1.9e-05 24.7 6.7 1.1 9.4 0.1 4.9 4 2 2 6 6 6 1 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 EPA06670.1 - 1.9e-05 24.7 5.8 0.19 11.9 0.0 5.2 3 1 3 6 6 6 2 Fis1 C-terminal tetratricopeptide repeat NARP1 PF12569.8 EPA06670.1 - 0.00088 18.3 3.2 0.62 8.9 0.9 2.8 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 ChAPs PF09295.10 EPA06670.1 - 0.0018 17.3 0.1 0.0031 16.6 0.1 1.3 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TOM20_plant PF06552.12 EPA06670.1 - 0.0028 17.4 1.2 4.1 7.1 0.0 3.7 2 2 1 3 3 3 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_20 PF14561.6 EPA06670.1 - 0.0084 16.4 1.6 0.15 12.4 0.2 3.2 1 1 3 4 4 4 1 Tetratricopeptide repeat MerR_1 PF13411.6 EPA06670.1 - 0.055 13.6 0.1 0.11 12.6 0.1 1.6 1 0 0 1 1 1 0 MerR HTH family regulatory protein PPR PF01535.20 EPA06670.1 - 0.057 13.7 1.5 25 5.4 0.0 4.0 4 0 0 4 4 3 0 PPR repeat HrpB1_HrpK PF09613.10 EPA06670.1 - 0.082 12.5 0.0 0.2 11.3 0.0 1.6 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) s48_45 PF07422.13 EPA06670.1 - 0.13 12.8 1.8 0.65 10.6 1.8 2.3 1 1 0 1 1 1 0 Sexual stage antigen s48/45 domain PknG_TPR PF16918.5 EPA06670.1 - 0.19 10.5 0.0 0.58 8.8 0.0 1.6 1 1 1 2 2 2 0 Protein kinase G tetratricopeptide repeat DUF627 PF04781.12 EPA06670.1 - 0.86 9.6 4.4 6.5 6.8 0.4 3.4 2 2 3 5 5 5 0 Protein of unknown function (DUF627) Arginase PF00491.21 EPA06671.1 - 1.1e-26 94.0 0.0 1.1e-26 94.0 0.0 1.0 1 0 0 1 1 1 1 Arginase family Rhodanese PF00581.20 EPA06673.1 - 2.8e-09 37.5 0.2 5.7e-09 36.5 0.2 1.4 1 1 0 1 1 1 1 Rhodanese-like domain DUF4389 PF14333.6 EPA06674.1 - 0.054 13.4 1.0 0.073 13.0 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) Ribosomal_S26e PF01283.19 EPA06675.1 - 7.1e-23 81.1 0.7 8.6e-23 80.8 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S26e CxC5 PF18718.1 EPA06675.1 - 0.0059 16.7 0.5 0.0071 16.4 0.5 1.1 1 0 0 1 1 1 1 CxC5 like cysteine cluster associated with KDZ transposases zinc_ribbon_11 PF11682.8 EPA06675.1 - 0.018 15.1 3.3 1.8 8.6 0.1 2.1 1 1 1 2 2 2 0 Probable zinc-ribbon zf-dskA_traR PF01258.17 EPA06675.1 - 0.047 13.6 1.0 1.1 9.3 0.1 2.3 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger TrkH PF02386.16 EPA06676.1 - 8.1e-25 87.2 28.4 8.9e-17 60.7 15.7 2.7 1 1 1 2 2 2 2 Cation transport protein CBS PF00571.28 EPA06676.1 - 1.1e-15 57.8 4.9 2.1e-07 31.3 0.4 2.6 2 0 0 2 2 2 2 CBS domain DUF4083 PF13314.6 EPA06677.1 - 0.94 9.5 6.7 3.2 7.8 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) zf-C2H2 PF00096.26 EPA06678.1 - 0.0007 19.9 0.5 0.0011 19.3 0.5 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EPA06678.1 - 0.0027 18.4 0.3 0.0044 17.7 0.3 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EPA06678.1 - 0.0036 17.6 1.3 0.0037 17.6 1.3 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 EPA06678.1 - 0.004 17.0 0.9 0.0045 16.8 0.9 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (1 copy) Actin_micro PF17003.5 EPA06678.1 - 0.006 15.8 2.5 0.006 15.8 2.5 1.0 1 0 0 1 1 1 1 Putative actin-like family CTU2 PF10288.9 EPA06678.1 - 0.024 14.9 0.2 0.024 14.9 0.2 1.0 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 DUF629 PF04780.12 EPA06678.1 - 0.031 12.8 0.9 0.029 12.9 0.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) Arginase PF00491.21 EPA06679.1 - 1.7e-36 126.2 0.0 2.3e-36 125.8 0.0 1.0 1 0 0 1 1 1 1 Arginase family CDP-OH_P_transf PF01066.21 EPA06681.1 - 3.9e-11 43.5 0.5 3.9e-11 43.5 0.5 2.4 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase tRNA-Thr_ED PF08915.11 EPA06682.1 - 1.8e-45 154.4 0.2 2e-45 154.2 0.2 1.0 1 0 0 1 1 1 1 Archaea-specific editing domain of threonyl-tRNA synthetase HGTP_anticodon PF03129.20 EPA06683.1 - 9e-24 83.5 0.3 1.7e-23 82.5 0.3 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EPA06683.1 - 1.3e-15 57.9 0.2 2.5e-15 56.9 0.2 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HTH_45 PF14947.6 EPA06684.1 - 2.9e-06 27.2 0.5 4.9e-06 26.4 0.5 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 EPA06684.1 - 2.1e-05 24.4 0.0 3.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.6 EPA06684.1 - 0.024 14.8 0.0 0.036 14.3 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain PadR PF03551.14 EPA06684.1 - 0.067 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_24 PF13412.6 EPA06684.1 - 0.078 12.6 0.1 0.15 11.6 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding CBS PF00571.28 EPA06685.1 - 6.1e-15 55.4 0.2 2.9e-10 40.5 0.0 2.2 2 0 0 2 2 2 2 CBS domain HTH_3 PF01381.22 EPA06685.1 - 1.6e-13 50.5 0.3 2.9e-13 49.6 0.3 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 EPA06685.1 - 1.9e-08 34.2 0.1 3.5e-08 33.4 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 EPA06685.1 - 2.1e-06 28.0 0.0 3.2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 EPA06685.1 - 0.0086 15.9 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MqsA_antitoxin PF15731.5 EPA06685.1 - 0.022 14.9 0.0 0.044 13.9 0.0 1.4 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA HTH_Crp_2 PF13545.6 EPA06685.1 - 0.087 12.8 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Sigma70_r4 PF04545.16 EPA06685.1 - 0.13 11.8 0.1 0.26 10.9 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 YdaS_antitoxin PF15943.5 EPA06685.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Hemerythrin PF01814.23 EPA06686.1 - 8.1e-12 45.9 0.4 1.2e-11 45.3 0.1 1.5 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain Nuf2 PF03800.14 EPA06686.1 - 0.026 14.6 0.3 0.34 11.0 0.0 2.0 2 0 0 2 2 2 0 Nuf2 family APC1_C PF18122.1 EPA06686.1 - 0.064 13.2 0.0 0.072 13.0 0.0 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex sub unit 1 C-terminal domain TryThrA_C PF12319.8 EPA06687.1 - 0.0072 15.8 0.9 0.0072 15.8 0.9 1.0 1 0 0 1 1 1 1 Tryptophan-Threonine-rich plasmodium antigen C terminal Fibin PF15819.5 EPA06687.1 - 0.047 13.4 0.1 0.047 13.4 0.1 1.0 1 0 0 1 1 1 0 Fin bud initiation factor homologue NAD_binding_9 PF13454.6 EPA06687.1 - 0.23 11.4 0.0 0.24 11.4 0.0 1.0 1 0 0 1 1 1 0 FAD-NAD(P)-binding Glyoxalase_4 PF13669.6 EPA06688.1 - 1.3e-22 80.1 0.0 1.5e-22 79.9 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 EPA06688.1 - 9.8e-12 45.2 0.0 1e-11 45.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EPA06688.1 - 1.6e-10 41.4 0.0 1.8e-10 41.2 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 EPA06688.1 - 0.004 17.9 0.0 0.005 17.6 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain TPR_10 PF13374.6 EPA06688.1 - 0.025 14.5 0.1 0.042 13.7 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat CTP_transf_like PF01467.26 EPA06690.1 - 7.9e-15 55.3 0.0 1.4e-14 54.5 0.0 1.6 1 1 0 1 1 1 1 Cytidylyltransferase-like HIGH_NTase1 PF05636.11 EPA06690.1 - 5e-05 22.7 0.1 0.0016 17.7 0.0 2.1 2 0 0 2 2 2 1 HIGH Nucleotidyl Transferase Citrate_ly_lig PF08218.11 EPA06690.1 - 0.0072 16.0 0.0 0.075 12.7 0.0 2.1 1 1 1 2 2 2 1 Citrate lyase ligase C-terminal domain MazG PF03819.17 EPA06690.1 - 0.064 13.4 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain Pantoate_ligase PF02569.15 EPA06690.1 - 0.087 12.0 0.0 0.14 11.3 0.0 1.4 1 1 0 1 1 1 0 Pantoate-beta-alanine ligase Peptidase_M1 PF01433.20 EPA06691.1 - 4.7e-89 297.7 1.4 9.2e-89 296.7 1.4 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EPA06691.1 - 2.5e-63 214.5 0.4 9.2e-63 212.7 0.1 1.9 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EPA06691.1 - 1.1e-54 185.5 4.1 2.3e-54 184.4 4.1 1.6 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Aminopep PF10023.9 EPA06691.1 - 0.0049 16.3 0.1 0.016 14.6 0.1 1.8 1 0 0 1 1 1 1 Putative aminopeptidase DUF3013 PF11217.8 EPA06691.1 - 0.055 13.3 0.9 0.29 11.0 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3013) MeaB PF03308.16 EPA06693.1 - 1.9e-66 223.8 2.8 2.5e-66 223.4 2.8 1.1 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 EPA06693.1 - 2.4e-06 27.3 0.1 5.3e-06 26.1 0.1 1.6 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 EPA06693.1 - 1.2e-05 25.2 0.3 0.0051 16.6 0.1 2.2 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EPA06693.1 - 3.6e-05 23.7 0.9 0.0098 15.8 0.1 2.5 2 1 0 2 2 2 1 RsgA GTPase KAP_NTPase PF07693.14 EPA06693.1 - 0.00071 18.9 0.3 0.00072 18.9 0.3 1.3 1 1 0 1 1 1 1 KAP family P-loop domain AAA_16 PF13191.6 EPA06693.1 - 0.0043 17.4 0.1 0.0057 17.0 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 EPA06693.1 - 0.0045 17.1 1.0 0.014 15.4 1.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EPA06693.1 - 0.012 16.2 0.1 0.023 15.2 0.1 1.7 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 EPA06693.1 - 0.012 15.8 0.0 0.035 14.4 0.1 1.7 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EPA06693.1 - 0.014 15.4 0.2 0.035 14.0 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EPA06693.1 - 0.017 14.8 0.4 0.026 14.2 0.4 1.4 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 EPA06693.1 - 0.018 14.8 0.2 0.039 13.7 0.2 1.6 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family NTPase_1 PF03266.15 EPA06693.1 - 0.033 14.1 0.2 0.09 12.7 0.2 1.7 1 0 0 1 1 1 0 NTPase AAA_10 PF12846.7 EPA06693.1 - 0.046 12.6 0.2 0.094 11.6 0.1 1.5 2 0 0 2 2 2 0 AAA-like domain AAA_29 PF13555.6 EPA06693.1 - 0.056 13.2 0.3 0.12 12.1 0.3 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 EPA06693.1 - 0.06 12.5 0.1 0.1 11.8 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain MnmE_helical PF12631.7 EPA06693.1 - 0.074 13.2 0.0 0.08 13.1 0.0 1.4 1 1 0 1 1 1 0 MnmE helical domain AAA_35 PF14516.6 EPA06693.1 - 0.093 11.5 0.1 0.14 10.9 0.1 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_23 PF13476.6 EPA06693.1 - 0.11 13.0 5.7 1.7 9.1 5.6 2.1 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EPA06693.1 - 0.13 12.6 0.4 0.16 12.3 0.4 1.5 1 1 0 1 1 1 0 AAA domain IlvN PF07991.12 EPA06694.1 - 1.2e-66 223.4 0.5 1.6e-66 222.9 0.5 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 EPA06694.1 - 1.9e-57 193.6 1.9 2.8e-57 193.1 1.9 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain 2-Hacid_dh_C PF02826.19 EPA06694.1 - 6.7e-06 25.6 0.1 1.2e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EPA06694.1 - 1.3e-05 25.5 0.3 0.00013 22.2 0.1 2.5 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EPA06694.1 - 0.00019 22.0 0.1 0.00062 20.3 0.1 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 EPA06694.1 - 0.016 15.3 0.2 0.038 14.0 0.2 1.6 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain MM_CoA_mutase PF01642.22 EPA06695.1 - 3.9e-212 705.3 0.2 4.5e-212 705.2 0.2 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase HigB_toxin PF09907.9 EPA06695.1 - 0.049 13.9 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system GTP_EFTU_D2 PF03144.25 EPA06696.1 - 2.1e-10 40.8 0.2 4.6e-10 39.7 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EPA06696.1 - 0.077 12.9 0.5 0.15 11.9 0.5 1.5 1 0 0 1 1 1 0 Elongation factor Tu domain 4 DUF4503 PF14951.6 EPA06697.1 - 0.00058 18.4 0.6 0.00059 18.4 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4503) zinc_ribbon_4 PF13717.6 EPA06697.1 - 0.0015 18.4 4.5 0.013 15.4 4.5 2.0 1 1 0 1 1 1 1 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EPA06697.1 - 0.033 14.3 3.4 0.11 12.7 1.0 2.2 2 1 0 2 2 2 0 Zinc ribbon domain zf-RRN7 PF11781.8 EPA06697.1 - 0.043 13.5 1.2 0.076 12.7 1.2 1.5 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DUF35_N PF12172.8 EPA06697.1 - 0.061 13.2 3.7 0.22 11.4 1.0 2.2 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Zn_Tnp_IS1595 PF12760.7 EPA06697.1 - 0.086 12.8 5.5 0.13 12.3 5.5 1.4 1 1 0 1 1 1 0 Transposase zinc-ribbon domain DUF1451 PF07295.11 EPA06697.1 - 0.28 11.2 2.6 0.28 11.2 0.5 1.8 2 0 0 2 2 2 0 Zinc-ribbon containing domain TF_Zn_Ribbon PF08271.12 EPA06697.1 - 0.32 10.6 5.4 0.86 9.2 5.3 1.9 1 1 0 1 1 1 0 TFIIB zinc-binding Sgf11 PF08209.11 EPA06697.1 - 1.2 8.8 7.0 1.9 8.1 0.2 2.3 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Prim_Zn_Ribbon PF08273.12 EPA06697.1 - 1.6 9.0 7.8 3.7 7.9 7.8 1.7 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase B12-binding PF02310.19 EPA06698.1 - 2e-21 76.2 0.1 2.3e-21 76.1 0.1 1.0 1 0 0 1 1 1 1 B12 binding domain IMPDH PF00478.25 EPA06698.1 - 0.017 14.2 0.0 0.021 13.8 0.0 1.1 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain Isochorismatase PF00857.20 EPA06698.1 - 0.043 14.0 0.1 25 5.0 0.1 2.9 1 1 1 3 3 3 0 Isochorismatase family Peptidase_M22 PF00814.25 EPA06698.1 - 0.15 11.7 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 Glycoprotease family CBS PF00571.28 EPA06699.1 - 4.8e-20 71.8 0.8 2.8e-10 40.5 0.0 2.2 2 0 0 2 2 2 2 CBS domain AAA PF00004.29 EPA06700.1 - 3.5e-64 215.2 0.0 1.2e-47 161.6 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EPA06700.1 - 6.2e-24 83.5 0.8 2.8e-12 46.2 0.0 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EPA06700.1 - 1.1e-07 32.3 0.1 6.7e-06 26.6 0.1 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.14 EPA06700.1 - 3.5e-06 27.2 0.0 9.3e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EPA06700.1 - 5.6e-05 22.5 0.2 0.00038 19.8 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 EPA06700.1 - 0.00019 21.7 0.1 0.0015 18.8 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EPA06700.1 - 0.00021 21.3 0.2 0.0052 16.8 0.1 3.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EPA06700.1 - 0.00038 20.6 0.0 0.00083 19.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EPA06700.1 - 0.0018 18.0 0.0 0.0059 16.4 0.0 1.9 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 EPA06700.1 - 0.0041 16.8 0.0 0.02 14.6 0.0 2.0 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 EPA06700.1 - 0.01 15.9 0.0 0.027 14.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EPA06700.1 - 0.011 15.5 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein TsaE PF02367.17 EPA06700.1 - 0.016 15.2 0.2 0.044 13.8 0.1 1.7 1 1 1 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Vps4_C PF09336.10 EPA06700.1 - 0.034 14.2 1.0 8.3 6.5 0.1 2.5 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain NACHT PF05729.12 EPA06700.1 - 0.038 13.9 0.1 0.39 10.6 0.1 2.2 1 1 1 2 2 2 0 NACHT domain Bac_DnaA PF00308.18 EPA06700.1 - 0.046 13.6 0.1 1.7 8.4 0.0 2.7 3 0 0 3 3 3 0 Bacterial dnaA protein PhoH PF02562.16 EPA06700.1 - 0.061 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_7 PF12775.7 EPA06700.1 - 0.065 12.7 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EPA06700.1 - 0.068 13.6 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase ATPase PF06745.13 EPA06700.1 - 0.1 12.0 0.3 0.62 9.4 0.0 2.4 3 0 0 3 3 3 0 KaiC Mg_chelatase PF01078.21 EPA06700.1 - 0.1 11.9 0.5 0.24 10.7 0.1 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EPA06700.1 - 0.11 13.0 0.2 0.72 10.4 0.0 2.4 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EPA06700.1 - 0.15 12.5 0.0 0.44 11.1 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 EPA06700.1 - 0.17 12.1 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain GatD_N PF18195.1 EPA06701.1 - 2.8e-17 61.8 0.4 3.8e-17 61.3 0.4 1.2 1 0 0 1 1 1 1 GatD N-terminal domain MG2 PF01835.19 EPA06702.1 - 0.0044 17.4 0.1 0.0082 16.6 0.1 1.5 1 0 0 1 1 1 1 MG2 domain DUF4458 PF14660.6 EPA06702.1 - 0.13 12.5 0.5 0.28 11.4 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4458) DUF2187 PF09953.9 EPA06702.1 - 0.17 11.9 1.5 1.1 9.3 0.1 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2187) RNA_pol_Rpb2_6 PF00562.28 EPA06703.1 - 5.1e-125 417.6 0.0 7.6e-125 417.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EPA06703.1 - 2.5e-48 164.3 0.0 3.8e-48 163.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EPA06703.1 - 3.5e-32 110.6 0.1 7.5e-32 109.6 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EPA06703.1 - 1.2e-27 95.8 0.1 2.9e-27 94.6 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 EPA06703.1 - 1.5e-23 83.5 0.0 3.4e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 EPA06703.1 - 4.9e-19 68.4 0.1 1.1e-18 67.2 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 EPA06703.1 - 7.5e-09 36.0 0.0 1.9e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 FYVE_2 PF02318.16 EPA06703.1 - 0.1 12.8 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger OrfB_Zn_ribbon PF07282.11 EPA06703.1 - 0.27 11.2 2.3 0.59 10.1 1.5 2.0 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Ribosomal_L37e PF01907.19 EPA06703.1 - 0.37 11.0 0.9 0.83 9.9 0.9 1.5 1 0 0 1 1 1 0 Ribosomal protein L37e RecR PF02132.15 EPA06703.1 - 0.56 9.8 2.1 1.9 8.1 0.6 2.3 2 0 0 2 2 2 0 RecR protein MG2 PF01835.19 EPA06704.1 - 5.3e-05 23.6 0.2 0.0098 16.3 0.1 2.5 2 1 0 2 2 2 2 MG2 domain P_proprotein PF01483.20 EPA06704.1 - 0.0066 16.4 0.0 0.049 13.6 0.0 2.2 2 0 0 2 2 2 1 Proprotein convertase P-domain Trp_ring PF18669.1 EPA06704.1 - 1.2 9.4 4.3 3.7 7.8 0.3 2.8 3 0 0 3 3 3 0 Trimeric autotransporter adhesin Trp ring domain DUF1425 PF07233.12 EPA06705.1 - 0.2 11.6 0.9 1.5 8.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1425) HCBP_related PF06594.11 EPA06705.1 - 1.5 8.8 5.9 5.3 7.1 0.1 4.4 3 1 1 4 4 4 0 Haemolysin-type calcium binding protein related domain LSM PF01423.22 EPA06706.1 - 5.7e-17 61.2 2.3 6.4e-17 61.0 2.3 1.0 1 0 0 1 1 1 1 LSM domain Big_3_5 PF16640.5 EPA06707.1 - 0.0032 17.6 1.0 0.0054 16.9 1.0 1.5 1 1 0 1 1 1 1 Bacterial Ig-like domain (group 3) MG2 PF01835.19 EPA06708.1 - 0.0024 18.3 0.1 0.0051 17.2 0.1 1.6 1 0 0 1 1 1 1 MG2 domain CBM60 PF16841.5 EPA06708.1 - 0.065 13.7 0.2 0.31 11.5 0.0 2.1 2 0 0 2 2 2 0 Ca-dependent carbohydrate-binding module xylan-binding RNA_pol_Rpb1_1 PF04997.12 EPA06709.1 - 3.3e-93 312.5 0.0 1.5e-92 310.3 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EPA06709.1 - 7.5e-84 281.3 1.7 1.7e-83 280.1 1.7 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EPA06709.1 - 3.5e-73 245.3 0.0 5.8e-73 244.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EPA06709.1 - 6.8e-35 120.3 0.0 2e-34 118.8 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EPA06709.1 - 8e-24 83.7 0.2 1.4e-22 79.6 0.1 2.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 Peptidase_C34 PF05413.11 EPA06709.1 - 0.075 13.3 0.0 13 6.1 0.0 2.8 2 0 0 2 2 2 0 Putative closterovirus papain-like endopeptidase RNA_pol_Rpb5_C PF01191.19 EPA06710.1 - 6.7e-27 93.2 0.1 7.9e-27 92.9 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain PD40 PF07676.12 EPA06711.1 - 5e-19 67.7 16.3 4.4e-05 23.3 0.5 5.4 5 0 0 5 5 5 4 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 EPA06711.1 - 8.3e-06 24.8 0.5 0.045 12.5 0.2 3.2 1 1 1 2 2 2 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5050 PF16472.5 EPA06711.1 - 2.2e-05 23.9 0.2 0.00075 18.8 0.2 2.8 1 1 1 2 2 2 2 Domain of unknown function (DUF5050) Pectate_lyase22 PF14583.6 EPA06711.1 - 0.0052 15.5 0.1 0.28 9.8 0.0 2.2 2 0 0 2 2 2 2 Oligogalacturonate lyase Tachylectin PF14517.6 EPA06711.1 - 0.019 14.5 0.5 0.033 13.7 0.5 1.4 1 0 0 1 1 1 0 Tachylectin Big_11 PF18200.1 EPA06711.1 - 0.42 10.6 2.5 7.6 6.5 0.2 3.0 2 1 1 3 3 3 0 Bacterial Ig-like domain Lactonase PF10282.9 EPA06712.1 - 6.1e-10 38.9 3.6 0.0022 17.3 0.0 3.8 1 1 2 4 4 4 4 Lactonase, 7-bladed beta-propeller NHL PF01436.21 EPA06712.1 - 1.5e-07 31.1 7.7 0.055 13.5 0.1 4.6 4 0 0 4 4 4 3 NHL repeat PD40 PF07676.12 EPA06712.1 - 1.7e-06 27.8 0.5 5.6e-06 26.2 0.5 2.0 1 0 0 1 1 1 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 EPA06712.1 - 4e-06 25.6 0.6 0.0096 14.5 0.1 2.6 1 1 2 3 3 3 2 Cytochrome D1 heme domain Arylesterase PF01731.20 EPA06712.1 - 1.4e-05 25.2 14.6 1.1 9.5 0.1 6.1 3 2 3 6 6 6 3 Arylesterase SGL PF08450.12 EPA06712.1 - 0.0028 17.3 3.1 0.13 11.8 0.1 3.2 2 2 1 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region DUF4221 PF13970.6 EPA06712.1 - 0.015 14.9 3.1 0.43 10.1 0.1 3.2 2 2 1 3 3 3 0 Domain of unknown function (DUF4221) ANAPC4_WD40 PF12894.7 EPA06712.1 - 0.015 15.6 0.0 12 6.3 0.0 2.8 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain FlaG PF03646.15 EPA06712.1 - 1.8 8.8 5.8 2.1 8.6 0.2 3.2 4 0 0 4 4 4 0 FlaG protein DUF4878 PF12870.7 EPA06713.1 - 0.0034 17.7 0.3 0.0085 16.4 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4878) Cas_Cas4 PF01930.17 EPA06714.1 - 8.6e-05 22.7 0.3 0.00013 22.1 0.2 1.5 1 1 0 1 1 1 1 Domain of unknown function DUF83 DDE_Tnp_1_6 PF13751.6 EPA06714.1 - 0.038 14.2 0.3 0.075 13.3 0.3 1.4 1 0 0 1 1 1 0 Transposase DDE domain PDDEXK_1 PF12705.7 EPA06714.1 - 0.19 11.6 1.8 3.5 7.5 1.8 2.0 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily AA_kinase PF00696.28 EPA06716.1 - 1.3e-26 93.7 0.2 4.3e-26 92.0 0.0 1.8 2 0 0 2 2 2 1 Amino acid kinase family ACT PF01842.25 EPA06716.1 - 3.9e-21 74.5 0.8 2.7e-09 36.6 0.1 2.3 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 EPA06716.1 - 5.2e-19 67.8 4.5 4e-12 45.7 0.3 2.4 2 0 0 2 2 2 2 ACT domain ACT_6 PF13740.6 EPA06716.1 - 0.0084 16.1 1.7 0.51 10.4 0.1 3.0 3 0 0 3 3 3 1 ACT domain Mfa_like_1 PF13149.6 EPA06716.1 - 0.032 14.3 0.6 0.05 13.7 0.6 1.3 1 0 0 1 1 1 0 Fimbrillin-like Thiolase_N PF00108.23 EPA06717.1 - 2.4e-21 76.3 0.0 1e-20 74.2 0.0 2.0 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EPA06717.1 - 4e-12 45.9 0.5 4.2e-10 39.4 0.0 3.0 2 1 1 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EPA06717.1 - 9e-05 22.2 0.2 0.04 13.5 0.1 2.8 3 0 0 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EPA06717.1 - 0.041 13.9 0.8 3.5 7.7 0.0 3.2 3 0 0 3 3 3 0 Beta-ketoacyl synthase, C-terminal domain Methyltransf_25 PF13649.6 EPA06718.1 - 3.1e-13 50.3 0.0 3.8e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA06718.1 - 2.1e-12 47.1 0.3 2.5e-12 46.9 0.3 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EPA06718.1 - 2.1e-11 43.6 0.0 2.2e-11 43.5 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EPA06718.1 - 1.4e-09 38.5 0.0 1.8e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EPA06718.1 - 1.9e-06 27.5 0.0 2.3e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EPA06718.1 - 4.5e-06 27.3 0.0 6e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EPA06718.1 - 6.2e-06 26.1 0.0 7.4e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EPA06718.1 - 0.00012 21.9 0.0 0.00014 21.7 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 EPA06718.1 - 0.00018 20.7 0.0 0.00021 20.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PrmA PF06325.13 EPA06718.1 - 0.00046 19.7 0.2 0.00058 19.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 EPA06718.1 - 0.0016 18.1 0.0 0.0019 17.9 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) MetW PF07021.12 EPA06718.1 - 0.0041 16.8 0.0 0.005 16.5 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW FtsJ PF01728.19 EPA06718.1 - 0.0059 16.7 0.0 0.0065 16.6 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase CMAS PF02353.20 EPA06718.1 - 0.038 13.3 0.0 0.038 13.3 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltr_RsmB-F PF01189.17 EPA06718.1 - 0.041 13.5 0.0 0.05 13.2 0.0 1.1 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Fibrillarin PF01269.17 EPA06718.1 - 0.096 11.8 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Fibrillarin CheR PF01739.18 EPA06718.1 - 0.76 9.2 3.7 1.4 8.3 1.0 2.1 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain zf-C4_Topoisom PF01396.19 EPA06719.1 - 1.5e-07 31.1 7.9 3e-06 26.9 1.0 2.7 2 0 0 2 2 2 2 Topoisomerase DNA binding C4 zinc finger Ogr_Delta PF04606.12 EPA06719.1 - 0.008 16.1 9.7 0.58 10.2 1.6 3.2 2 2 0 2 2 2 2 Ogr/Delta-like zinc finger Phage_HK97_TLTM PF06120.11 EPA06719.1 - 0.098 11.8 0.2 0.18 10.9 0.1 1.4 1 1 1 2 2 2 0 Tail length tape measure protein Zn_ribbon_recom PF13408.6 EPA06719.1 - 0.53 10.9 7.9 1.3 9.6 0.8 2.4 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain DUF1129 PF06570.11 EPA06720.1 - 0.073 12.6 0.0 0.076 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DZR PF12773.7 EPA06721.1 - 7.7e-05 22.6 0.4 9.9e-05 22.3 0.4 1.1 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 EPA06721.1 - 0.00013 21.3 3.2 0.08 12.4 0.4 2.2 2 0 0 2 2 2 2 zinc-ribbon domain zinc_ribbon_2 PF13240.6 EPA06721.1 - 0.00052 19.6 3.6 0.13 12.1 0.3 2.2 2 0 0 2 2 2 2 zinc-ribbon domain zf_UBZ PF18439.1 EPA06721.1 - 0.0011 18.5 0.7 1.2 8.8 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger TF_Zn_Ribbon PF08271.12 EPA06721.1 - 0.0025 17.3 0.8 0.48 10.0 0.1 2.2 2 0 0 2 2 2 1 TFIIB zinc-binding zf-LITAF-like PF10601.9 EPA06721.1 - 0.0026 18.0 0.4 0.77 10.1 0.0 2.2 2 0 0 2 2 2 1 LITAF-like zinc ribbon domain zf-C4_Topoisom PF01396.19 EPA06721.1 - 0.0061 16.3 2.9 0.25 11.2 0.3 2.2 2 0 0 2 2 2 1 Topoisomerase DNA binding C4 zinc finger Chordopox_RPO7 PF05864.12 EPA06721.1 - 0.0069 16.6 0.4 0.044 14.0 0.4 2.1 1 1 0 1 1 1 1 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) zf-TFIIB PF13453.6 EPA06721.1 - 0.0079 15.5 1.0 0.03 13.6 0.2 2.0 2 0 0 2 2 2 1 Transcription factor zinc-finger zf-ACC PF17848.1 EPA06721.1 - 0.01 15.9 2.9 0.24 11.5 0.2 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain FANCL_C PF11793.8 EPA06721.1 - 0.011 15.9 1.3 0.041 14.1 1.2 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain HypA PF01155.19 EPA06721.1 - 0.012 15.7 0.2 0.013 15.5 0.2 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Sgf11 PF08209.11 EPA06721.1 - 0.015 14.8 0.6 2.1 8.0 0.1 2.1 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) YhfH PF14149.6 EPA06721.1 - 0.016 15.2 4.3 2 8.4 0.1 2.2 2 0 0 2 2 2 0 YhfH-like protein DUF4428 PF14471.6 EPA06721.1 - 0.028 14.3 3.8 2.2 8.3 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) zf-dskA_traR PF01258.17 EPA06721.1 - 0.029 14.3 0.3 2.5 8.1 0.0 2.1 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger DiS_P_DiS PF06750.13 EPA06721.1 - 0.034 14.3 0.6 0.11 12.6 0.6 1.7 1 1 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain zinc_ribbon_4 PF13717.6 EPA06721.1 - 0.036 14.0 2.0 2.6 8.1 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain LIM PF00412.22 EPA06721.1 - 0.036 14.3 0.2 0.083 13.1 0.2 1.6 1 1 0 1 1 1 0 LIM domain zf-ISL3 PF14690.6 EPA06721.1 - 0.044 14.4 0.4 6.2 7.6 0.1 2.1 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Zn-ribbon_8 PF09723.10 EPA06721.1 - 0.045 13.9 2.4 0.21 11.8 2.4 1.9 1 1 0 1 1 1 0 Zinc ribbon domain UPF0547 PF10571.9 EPA06721.1 - 0.053 13.6 1.5 0.31 11.1 0.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zinc-ribbons_6 PF07191.12 EPA06721.1 - 0.054 13.5 1.0 0.67 10.0 1.0 2.0 1 1 0 1 1 1 0 zinc-ribbons zf-C2HC5 PF06221.13 EPA06721.1 - 0.054 13.5 2.4 0.14 12.1 2.4 1.7 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type zf-Di19 PF05605.12 EPA06721.1 - 0.056 13.8 0.2 0.22 11.8 0.2 1.8 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding TFIIS_C PF01096.18 EPA06721.1 - 0.081 12.8 1.8 6.9 6.6 0.1 2.1 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Zn_ribbon_SprT PF17283.2 EPA06721.1 - 0.082 12.8 1.5 1.6 8.7 0.1 2.1 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Ogr_Delta PF04606.12 EPA06721.1 - 0.084 12.9 0.3 3.2 7.8 0.1 2.1 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger zf-C3HC4_3 PF13920.6 EPA06721.1 - 0.09 12.7 1.5 0.46 10.4 1.5 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C2H2 PF00096.26 EPA06721.1 - 0.12 12.8 1.5 11 6.7 0.0 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF983 PF06170.12 EPA06721.1 - 0.15 12.5 0.2 5.9 7.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Cript PF10235.9 EPA06721.1 - 0.16 12.6 3.8 0.44 11.1 3.8 1.6 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT zf-NADH-PPase PF09297.11 EPA06721.1 - 0.32 10.7 4.4 5 6.9 0.3 2.1 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Fer2_BFD PF04324.15 EPA06721.1 - 0.41 11.0 3.4 10 6.6 0.6 2.2 1 1 1 2 2 2 0 BFD-like [2Fe-2S] binding domain zf_C2H2_10 PF18414.1 EPA06721.1 - 0.41 10.2 2.2 6.4 6.4 0.1 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger CpXC PF14353.6 EPA06721.1 - 0.45 10.6 2.9 23 5.0 3.0 2.1 1 1 0 1 1 1 0 CpXC protein Rubredoxin_2 PF18073.1 EPA06721.1 - 0.47 10.2 5.5 0.45 10.3 0.9 2.1 2 0 0 2 2 2 0 Rubredoxin metal binding domain OrfB_Zn_ribbon PF07282.11 EPA06721.1 - 0.65 10.0 3.2 4.1 7.4 0.3 2.0 1 1 1 2 2 2 0 Putative transposase DNA-binding domain ADK_lid PF05191.14 EPA06721.1 - 1.4 9.0 5.5 8.4 6.5 5.4 2.0 1 1 0 1 1 1 0 Adenylate kinase, active site lid PPS_PS PF02006.16 EPA06722.1 - 4e-20 72.1 0.2 5.8e-20 71.6 0.2 1.2 1 0 0 1 1 1 1 Phosphopantothenate/pantothenate synthetase DUF3035 PF11233.8 EPA06722.1 - 0.048 13.9 0.1 0.063 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3035) TPP_enzyme_M PF00205.22 EPA06722.1 - 0.054 13.2 0.6 0.082 12.6 0.6 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain Aminotran_5 PF00266.19 EPA06723.1 - 3.1e-37 128.4 0.0 4.1e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EPA06723.1 - 9.4e-05 21.1 0.9 0.00014 20.5 0.9 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Lipoprotein_9 PF03180.14 EPA06723.1 - 0.057 12.5 0.0 0.093 11.8 0.0 1.2 1 0 0 1 1 1 0 NLPA lipoprotein HD PF01966.22 EPA06724.1 - 2e-17 63.5 0.2 4.5e-17 62.4 0.2 1.6 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 EPA06724.1 - 0.023 14.2 0.0 0.043 13.3 0.0 1.4 1 0 0 1 1 1 0 HDOD domain Glyco_trans_1_2 PF13524.6 EPA06725.1 - 0.049 14.0 0.0 0.077 13.4 0.0 1.4 1 1 0 1 1 1 0 Glycosyl transferases group 1 DUF3081 PF11280.8 EPA06725.1 - 0.18 11.7 0.0 15 5.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3081) OB_aCoA_assoc PF01796.17 EPA06727.1 - 8.4e-09 35.3 0.2 1.1e-08 34.9 0.2 1.2 1 0 0 1 1 1 1 DUF35 OB-fold domain, acyl-CoA-associated DUF35_N PF12172.8 EPA06727.1 - 1.2e-06 28.2 0.3 1.8e-06 27.7 0.3 1.2 1 0 0 1 1 1 1 Rubredoxin-like zinc ribbon domain (DUF35_N) zinc_ribbon_2 PF13240.6 EPA06727.1 - 0.00014 21.5 3.2 0.00023 20.8 3.2 1.4 1 0 0 1 1 1 1 zinc-ribbon domain TackOD1 PF18551.1 EPA06727.1 - 0.0018 18.0 0.3 0.0022 17.7 0.3 1.1 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 PHF5 PF03660.14 EPA06727.1 - 0.0048 17.1 0.2 0.0073 16.5 0.2 1.3 1 0 0 1 1 1 1 PHF5-like protein DZR PF12773.7 EPA06727.1 - 0.0089 16.0 0.3 0.014 15.4 0.3 1.3 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_10 PF10058.9 EPA06727.1 - 0.08 12.7 0.7 10 5.9 0.1 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein TFIIS_C PF01096.18 EPA06727.1 - 0.17 11.8 2.3 4.2 7.3 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) PfkB PF00294.24 EPA06728.1 - 1.8e-24 86.6 0.1 3.1e-24 85.8 0.1 1.3 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EPA06728.1 - 3.6e-05 23.3 0.0 6.7e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Carb_kinase PF01256.17 EPA06728.1 - 0.0021 17.6 0.4 0.81 9.1 0.1 2.5 2 1 1 3 3 3 2 Carbohydrate kinase OstA_2 PF13100.6 EPA06728.1 - 0.081 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 OstA-like protein MacB_PCD PF12704.7 EPA06729.1 - 8.8e-19 68.6 2.0 1.5e-18 67.9 2.0 1.3 1 0 0 1 1 1 1 MacB-like periplasmic core domain FtsX PF02687.21 EPA06729.1 - 3.2e-14 53.2 1.8 3.2e-14 53.2 1.8 2.2 2 0 0 2 2 2 1 FtsX-like permease family NikR_C PF08753.11 EPA06730.1 - 1.6e-11 44.2 2.3 2.5e-11 43.5 2.3 1.4 1 0 0 1 1 1 1 NikR C terminal nickel binding domain RHH_1 PF01402.21 EPA06730.1 - 1.6e-06 27.8 0.1 2.7e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family VapB_antitoxin PF09957.9 EPA06730.1 - 0.0039 17.1 0.0 0.0067 16.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial antitoxin of type II TA system, VapB DUF1327 PF07041.11 EPA06730.1 - 0.056 13.5 0.1 0.077 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1327) FeoC PF09012.10 EPA06731.1 - 0.0056 16.7 0.0 0.0085 16.1 0.0 1.3 1 0 0 1 1 1 1 FeoC like transcriptional regulator IPPT PF01715.17 EPA06731.1 - 0.0079 16.0 0.5 0.0096 15.8 0.5 1.0 1 0 0 1 1 1 1 IPP transferase HTH_45 PF14947.6 EPA06731.1 - 0.039 13.9 3.6 0.12 12.3 3.5 2.0 1 1 0 1 1 1 0 Winged helix-turn-helix Rio2_N PF09202.11 EPA06731.1 - 0.088 13.0 0.8 0.65 10.3 0.1 2.0 1 1 1 2 2 2 0 Rio2, N-terminal MarR PF01047.22 EPA06731.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 MarR family CN_hydrolase PF00795.22 EPA06735.1 - 2.6e-50 171.2 0.0 3.2e-50 170.9 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase zf-C2H2 PF00096.26 EPA06736.1 - 1.1e-06 28.7 4.1 0.0056 17.1 0.4 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EPA06736.1 - 4e-06 27.2 6.2 0.031 15.1 0.3 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger TF_Zn_Ribbon PF08271.12 EPA06736.1 - 0.0004 19.8 0.5 0.12 11.9 0.0 2.2 2 0 0 2 2 2 2 TFIIB zinc-binding zf-ribbon_3 PF13248.6 EPA06736.1 - 0.0033 16.8 0.9 0.35 10.3 0.1 2.3 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 EPA06736.1 - 0.0072 17.0 5.0 0.0079 16.9 5.0 1.1 1 0 0 1 1 1 1 zinc-ribbon family zf-C2H2_11 PF16622.5 EPA06736.1 - 0.017 14.9 2.1 1 9.2 0.1 2.3 1 1 1 2 2 2 0 zinc-finger C2H2-type zinc_ribbon_4 PF13717.6 EPA06736.1 - 0.03 14.3 4.1 1.2 9.1 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.7 EPA06736.1 - 0.032 14.2 5.4 0.048 13.7 5.4 1.4 1 1 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 EPA06736.1 - 0.037 14.1 4.4 0.037 14.1 4.4 2.1 1 1 1 2 2 2 0 Zinc ribbon domain DUF2688 PF10892.8 EPA06736.1 - 0.037 13.5 3.0 0.29 10.6 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2688) XPA_N PF01286.18 EPA06736.1 - 0.055 13.5 4.9 0.38 10.8 0.6 2.3 2 0 0 2 2 2 0 XPA protein N-terminal DUF35_N PF12172.8 EPA06736.1 - 0.059 13.3 2.8 1.5 8.7 0.2 2.2 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) RNA_POL_M_15KD PF02150.16 EPA06736.1 - 0.061 13.2 5.5 1.9 8.4 5.5 2.2 1 1 1 2 2 2 0 RNA polymerases M/15 Kd subunit ADK_lid PF05191.14 EPA06736.1 - 0.11 12.5 3.2 0.7 9.9 3.1 2.1 1 1 0 1 1 1 0 Adenylate kinase, active site lid FYVE PF01363.21 EPA06736.1 - 0.11 12.6 6.4 0.39 10.9 1.7 2.1 1 1 1 2 2 2 0 FYVE zinc finger DUF983 PF06170.12 EPA06736.1 - 0.15 12.5 1.9 4.3 7.8 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF983) zf_UBZ PF18439.1 EPA06736.1 - 0.17 11.5 4.4 4.2 7.0 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Ephrin_rec_like PF07699.13 EPA06736.1 - 0.26 11.1 7.1 0.41 10.4 1.4 2.1 1 1 1 2 2 2 0 Putative ephrin-receptor like zf-ACC PF17848.1 EPA06736.1 - 0.54 10.4 0.4 0.54 10.4 0.4 3.1 4 0 0 4 4 4 0 Acetyl-coA carboxylase zinc finger domain Fer4 PF00037.27 EPA06736.1 - 0.96 9.4 4.7 12 5.9 0.4 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Tautomerase PF01361.21 EPA06738.1 - 3.3e-12 46.2 0.0 3.3e-12 46.1 0.0 1.0 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_2 PF14552.6 EPA06738.1 - 3.5e-05 23.8 0.0 3.5e-05 23.8 0.0 1.0 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_3 PF14832.6 EPA06738.1 - 0.095 12.9 0.0 0.11 12.8 0.0 1.0 1 0 0 1 1 1 0 Putative oxalocrotonate tautomerase enzyme GHMP_kinases_N PF00288.26 EPA06740.1 - 9.6e-11 41.8 0.1 2e-10 40.8 0.1 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain Telomere_Sde2_2 PF13297.6 EPA06740.1 - 0.018 14.6 0.2 0.086 12.5 0.1 2.1 2 0 0 2 2 2 0 Telomere stability C-terminal AnfO_nitrog PF09582.10 EPA06740.1 - 0.052 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) Thymidylate_kin PF02223.17 EPA06741.1 - 2.1e-38 131.9 0.2 2.4e-38 131.7 0.2 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 EPA06741.1 - 0.0024 18.2 0.0 0.0031 17.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 EPA06741.1 - 0.0025 17.7 2.5 0.034 14.0 2.5 2.1 1 1 0 1 1 1 1 Deoxynucleoside kinase RNase_J_C PF17770.1 EPA06741.1 - 0.69 11.0 3.5 6.5 7.9 1.1 2.4 2 0 0 2 2 2 0 Ribonuclease J C-terminal domain vATP-synt_E PF01991.18 EPA06742.1 - 5.4e-19 68.4 5.0 5.4e-19 68.4 5.0 1.8 1 1 1 2 2 2 1 ATP synthase (E/31 kDa) subunit FliH PF02108.16 EPA06742.1 - 0.0074 16.3 0.8 0.025 14.7 0.8 2.0 1 1 0 1 1 1 1 Flagellar assembly protein FliH DUF4407 PF14362.6 EPA06742.1 - 0.021 14.2 0.6 0.032 13.6 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hamartin PF04388.12 EPA06742.1 - 0.083 11.5 0.6 0.088 11.5 0.6 1.0 1 0 0 1 1 1 0 Hamartin protein Imm30 PF15565.6 EPA06742.1 - 0.18 11.9 0.7 11 6.2 0.1 2.6 2 0 0 2 2 2 0 Immunity protein 30 YkyA PF10368.9 EPA06742.1 - 0.38 10.4 5.9 1.5 8.5 4.9 2.0 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein NUDIX PF00293.28 EPA06744.1 - 1.3e-17 64.0 0.0 1.7e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain TetR_C_10 PF16295.5 EPA06744.1 - 0.092 13.0 0.1 0.16 12.3 0.1 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Rhodanese PF00581.20 EPA06745.1 - 2.8e-42 143.6 0.2 2e-21 76.5 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain DUF334 PF03904.13 EPA06746.1 - 0.0097 15.5 2.2 0.014 14.9 2.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF334) SAM_2 PF07647.17 EPA06746.1 - 0.071 13.2 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) ABC_tran PF00005.27 EPA06747.1 - 1.8e-36 125.7 0.1 1.6e-35 122.6 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EPA06747.1 - 1.1e-13 51.7 0.8 5.5e-07 29.7 0.3 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EPA06747.1 - 6.4e-06 25.8 2.0 0.00027 20.4 2.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EPA06747.1 - 7.9e-05 23.2 3.2 0.00019 22.0 3.2 1.7 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EPA06747.1 - 0.00021 21.0 0.1 0.00038 20.1 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain IstB_IS21 PF01695.17 EPA06747.1 - 0.00076 19.3 0.2 0.89 9.3 0.0 2.7 2 1 1 3 3 3 2 IstB-like ATP binding protein AAA_27 PF13514.6 EPA06747.1 - 0.0011 18.6 0.0 0.0022 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EPA06747.1 - 0.0077 16.1 0.1 0.043 13.7 0.0 2.1 3 0 0 3 3 3 1 RsgA GTPase MMR_HSR1 PF01926.23 EPA06747.1 - 0.0091 16.1 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA PF00004.29 EPA06747.1 - 0.018 15.5 1.3 0.13 12.7 1.3 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EPA06747.1 - 0.02 14.1 0.0 0.046 12.9 0.0 1.6 1 1 0 1 1 1 0 NB-ARC domain AAA_22 PF13401.6 EPA06747.1 - 0.02 15.2 0.1 0.068 13.4 0.1 1.9 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 EPA06747.1 - 0.022 15.0 0.0 1.1 9.6 0.0 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.6 EPA06747.1 - 0.033 14.2 0.6 1.9 8.5 0.0 2.4 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.6 EPA06747.1 - 0.08 13.3 0.0 0.25 11.7 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_15 PF13175.6 EPA06747.1 - 0.1 12.3 6.4 0.24 11.1 6.4 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EPA06747.1 - 0.2 11.8 0.1 0.88 9.7 0.1 2.1 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.17 EPA06747.1 - 2.6 8.1 5.8 18 5.3 1.5 2.3 1 1 1 2 2 2 0 Helicase HerA, central domain DegT_DnrJ_EryC1 PF01041.17 EPA06748.1 - 7.2e-114 380.8 0.0 8.8e-114 380.6 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EPA06748.1 - 7.8e-09 35.0 0.1 1.2e-08 34.3 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EPA06748.1 - 8.2e-09 35.1 0.1 1.2e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EPA06748.1 - 3.3e-08 32.5 0.2 5.5e-08 31.8 0.2 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EPA06748.1 - 1.6e-05 24.4 0.0 4.9e-05 22.8 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase ComK PF06338.11 EPA06748.1 - 0.00034 20.3 0.0 0.00081 19.1 0.0 1.5 1 0 0 1 1 1 1 ComK protein NFACT-R_2 PF18297.1 EPA06749.1 - 3.2e-22 78.7 0.1 5.9e-22 77.8 0.1 1.5 1 0 0 1 1 1 1 NFACT protein RNA binding domain ThiI PF02568.14 EPA06749.1 - 1.4e-12 47.6 0.0 2.4e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 EPA06749.1 - 1.9e-08 33.5 0.1 3.6e-08 32.6 0.0 1.4 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.13 EPA06749.1 - 0.0034 16.9 0.2 0.011 15.3 0.1 1.8 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC NFACT-R_1 PF05670.13 EPA06749.1 - 0.027 15.1 0.0 0.076 13.7 0.0 1.8 1 1 0 1 1 1 0 NFACT protein RNA binding domain Asn_synthase PF00733.21 EPA06749.1 - 0.089 12.4 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase V_ATPase_I PF01496.19 EPA06750.1 - 1e-25 89.9 9.8 3.2e-19 68.4 0.0 3.1 3 0 0 3 3 3 3 V-type ATPase 116kDa subunit family Molybdopterin_N PF18364.1 EPA06750.1 - 0.37 10.8 1.6 13 5.9 0.1 2.9 3 0 0 3 3 3 0 Molybdopterin oxidoreductase N-terminal domain ATP-synt_C PF00137.21 EPA06752.1 - 6.3e-16 58.5 16.9 6.3e-16 58.5 16.9 2.0 2 0 0 2 2 2 1 ATP synthase subunit C Flavoprotein PF02441.19 EPA06753.1 - 1.2e-33 116.1 0.7 1.5e-33 115.8 0.7 1.0 1 0 0 1 1 1 1 Flavoprotein BRCT PF00533.26 EPA06753.1 - 0.051 14.0 0.0 0.096 13.1 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain NAD_binding_7 PF13241.6 EPA06753.1 - 0.07 13.6 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding YjeF_N PF03853.15 EPA06753.1 - 0.08 12.8 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 YjeF-related protein N-terminus SGL PF08450.12 EPA06754.1 - 7.5e-14 51.9 0.1 0.0024 17.5 0.0 5.2 1 1 4 5 5 5 5 SMP-30/Gluconolactonase/LRE-like region CopD PF05425.13 EPA06754.1 - 1.3e-13 51.2 2.6 1.3e-13 51.2 2.6 2.9 3 0 0 3 3 3 1 Copper resistance protein D CopC PF04234.12 EPA06754.1 - 1.5e-09 38.8 0.1 3.4e-09 37.6 0.1 1.7 1 0 0 1 1 1 1 CopC domain Reg_prop PF07494.11 EPA06754.1 - 6.4e-08 31.9 10.5 9.1 6.9 0.3 8.2 8 0 0 8 8 8 2 Two component regulator propeller YtkA PF13115.6 EPA06754.1 - 0.0039 17.8 0.2 0.015 15.9 0.0 2.1 2 1 0 2 2 2 1 YtkA-like PPC PF04151.15 EPA06754.1 - 0.17 13.0 0.6 0.88 10.7 0.6 2.2 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain DUF4149 PF13664.6 EPA06754.1 - 6.7 7.1 12.4 0.6 10.5 2.2 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4149) dUTPase_2 PF08761.11 EPA06755.1 - 2.1e-18 67.1 5.1 2.8e-13 50.4 0.2 2.0 1 1 1 2 2 2 2 dUTPase PRA-PH PF01503.17 EPA06755.1 - 0.00057 20.3 0.0 0.00072 20.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase Yuri_gagarin PF15934.5 EPA06756.1 - 0.00098 19.0 3.6 0.0011 18.9 3.6 1.1 1 0 0 1 1 1 1 Yuri gagarin DUF2730 PF10805.8 EPA06756.1 - 0.0043 17.1 1.9 0.0043 17.1 1.9 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF2730) Kei1 PF08552.11 EPA06756.1 - 0.0074 16.2 0.3 0.0087 16.0 0.3 1.2 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 MLANA PF14991.6 EPA06756.1 - 0.036 14.3 0.3 0.063 13.6 0.0 1.5 2 0 0 2 2 2 0 Protein melan-A Vps53_N PF04100.12 EPA06756.1 - 0.11 11.4 7.9 0.13 11.2 7.9 1.1 1 0 0 1 1 1 0 Vps53-like, N-terminal Allexi_40kDa PF05549.11 EPA06756.1 - 0.2 11.2 7.1 0.23 10.9 7.1 1.0 1 0 0 1 1 1 0 Allexivirus 40kDa protein Seryl_tRNA_N PF02403.22 EPA06756.1 - 0.24 11.6 7.9 0.16 12.2 5.9 1.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FAM76 PF16046.5 EPA06756.1 - 0.3 10.4 8.4 0.43 9.9 8.4 1.2 1 0 0 1 1 1 0 FAM76 protein CheY-binding PF09078.11 EPA06756.1 - 0.33 11.1 3.4 4.6 7.4 0.2 2.8 1 1 2 3 3 3 0 CheY binding DUF4763 PF15960.5 EPA06756.1 - 0.36 10.1 10.1 0.098 11.9 4.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) FlaC_arch PF05377.11 EPA06756.1 - 2.1 8.8 10.5 1.7 9.1 0.3 2.6 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF1931 PF09123.11 EPA06757.1 - 0.01 15.9 0.1 0.013 15.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1931) Ub-Mut7C PF14451.6 EPA06757.1 - 0.11 12.4 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Mut7-C ubiquitin CopD PF05425.13 EPA06758.1 - 3.3e-15 56.4 1.9 3.6e-15 56.2 0.2 1.7 2 0 0 2 2 2 1 Copper resistance protein D SieB PF14163.6 EPA06758.1 - 0.0035 16.9 3.1 0.0035 16.9 3.1 2.2 2 1 0 2 2 2 1 Super-infection exclusion protein B UPF0093 PF03653.13 EPA06758.1 - 0.0043 17.3 8.5 0.013 15.7 8.5 1.6 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0093) 7TM_GPCR_Srv PF10323.9 EPA06758.1 - 0.0075 15.7 1.9 0.011 15.1 1.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv PEMT PF04191.13 EPA06758.1 - 0.063 13.7 0.2 0.063 13.7 0.2 2.2 3 1 0 3 3 3 0 Phospholipid methyltransferase DUF4149 PF13664.6 EPA06758.1 - 0.082 13.2 6.3 0.38 11.1 6.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4149) Flavi_M PF01004.19 EPA06758.1 - 0.096 12.5 2.9 0.48 10.2 0.2 2.5 1 1 1 2 2 2 0 Flavivirus envelope glycoprotein M DUF3278 PF11683.8 EPA06758.1 - 1.3 9.1 10.5 0.21 11.7 6.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3278) DHHC PF01529.20 EPA06758.1 - 1.9 8.6 5.1 0.85 9.7 0.9 2.0 2 0 0 2 2 2 0 DHHC palmitoyltransferase Brr6_like_C_C PF10104.9 EPA06758.1 - 3.2 7.5 7.3 0.18 11.6 1.7 1.8 2 1 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain Arch_flagellin PF01917.16 EPA06759.1 - 0.0037 17.5 0.7 0.0043 17.3 0.7 1.2 1 0 0 1 1 1 1 Archaebacterial flagellin CTP_transf_like PF01467.26 EPA06760.1 - 4.6e-12 46.3 0.0 1.2e-11 45.0 0.0 1.7 1 1 0 1 1 1 1 Cytidylyltransferase-like Homeobox_KN PF05920.11 EPA06760.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Homeobox KN domain ZnuA PF01297.17 EPA06763.1 - 6e-69 232.3 0.3 6.9e-69 232.1 0.3 1.0 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic Wzt_C PF14524.6 EPA06764.1 - 8.2e-07 29.2 1.5 0.00018 21.6 0.2 2.4 2 0 0 2 2 2 2 Wzt C-terminal domain ApoM PF11032.8 EPA06764.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 ApoM domain DUF4927 PF16279.5 EPA06764.1 - 0.023 15.7 0.0 0.051 14.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4927) Peptidase_M24 PF00557.24 EPA06765.1 - 1.4e-55 188.2 0.0 1.6e-55 188.1 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 FKBP26_C PF18046.1 EPA06767.1 - 2.1e-12 46.9 0.9 6.5e-12 45.4 0.9 1.8 1 0 0 1 1 1 1 FKBP26_C-terminal FKBP_C PF00254.28 EPA06767.1 - 3.6e-11 43.2 0.2 2e-10 40.8 0.1 2.2 1 1 1 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase CAP_GLY PF01302.25 EPA06767.1 - 0.0023 17.9 0.0 0.0043 17.1 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain DUF5399 PF17377.2 EPA06767.1 - 0.18 11.6 0.2 0.18 11.6 0.2 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5399) NPCBM_assoc PF10633.9 EPA06768.1 - 0.00052 20.2 1.3 0.63 10.3 0.0 3.8 3 2 1 4 4 4 2 NPCBM-associated, NEW3 domain of alpha-galactosidase DUF11 PF01345.18 EPA06768.1 - 0.002 18.4 3.7 0.78 10.1 1.8 2.4 2 0 0 2 2 2 2 Domain of unknown function DUF11 DUF5385 PF17359.2 EPA06768.1 - 0.03 13.9 1.2 0.046 13.3 1.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5385) DUF4832 PF16116.5 EPA06768.1 - 0.066 13.1 0.3 0.11 12.3 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4832) Fe-ADH_2 PF13685.6 EPA06769.1 - 1.8e-72 244.1 1.2 1.8e-72 244.1 1.2 1.3 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 EPA06769.1 - 1.4e-22 80.1 0.5 8.3e-22 77.5 0.5 1.8 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 EPA06769.1 - 3.7e-05 23.0 0.4 0.0021 17.3 0.4 2.7 1 1 0 1 1 1 1 3-dehydroquinate synthase AIRC PF00731.20 EPA06769.1 - 0.0018 17.9 3.7 0.003 17.1 0.8 2.3 2 0 0 2 2 2 1 AIR carboxylase MtrA PF04208.14 EPA06770.1 - 7.1e-23 81.1 0.2 8.4e-23 80.9 0.2 1.0 1 0 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase, subunit A AA_kinase PF00696.28 EPA06772.1 - 1.2e-29 103.7 1.0 1.7e-29 103.1 1.0 1.2 1 0 0 1 1 1 1 Amino acid kinase family DFP PF04127.15 EPA06773.1 - 2e-57 194.0 1.8 2.5e-57 193.7 1.8 1.1 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein ABC_tran PF00005.27 EPA06774.1 - 2.1e-29 102.8 0.1 3e-29 102.3 0.1 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EPA06774.1 - 5.1e-06 26.1 4.3 5.5e-05 22.7 4.3 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EPA06774.1 - 0.00012 22.1 2.2 0.069 13.0 1.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EPA06774.1 - 0.0011 18.7 0.5 0.0064 16.2 0.4 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EPA06774.1 - 0.0026 17.7 1.1 0.011 15.6 0.2 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_13 PF13166.6 EPA06774.1 - 0.0047 15.7 2.0 0.034 12.8 0.2 2.0 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 EPA06774.1 - 0.012 14.8 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_15 PF13175.6 EPA06774.1 - 0.013 15.2 1.4 0.16 11.6 0.2 2.1 1 1 0 2 2 2 0 AAA ATPase domain AAA_16 PF13191.6 EPA06774.1 - 0.019 15.4 0.0 0.03 14.7 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain NYN PF01936.18 EPA06774.1 - 0.021 15.3 0.4 0.07 13.6 0.4 1.7 1 1 0 1 1 1 0 NYN domain AAA_22 PF13401.6 EPA06774.1 - 0.031 14.6 0.3 0.065 13.5 0.3 1.9 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 EPA06774.1 - 0.056 13.5 1.0 0.56 10.2 0.1 2.2 2 0 0 2 2 2 0 Dynamin family AAA_23 PF13476.6 EPA06774.1 - 0.07 13.6 1.5 0.13 12.7 1.6 1.6 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 EPA06774.1 - 0.11 12.1 1.2 0.44 10.1 0.2 2.2 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 EPA06774.1 - 0.12 12.0 1.3 0.15 11.7 0.2 1.7 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EPA06774.1 - 0.17 11.2 1.7 0.39 10.0 0.6 2.1 3 0 0 3 3 3 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 EPA06774.1 - 0.19 11.8 2.4 0.32 11.1 2.4 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 EPA06774.1 - 0.33 11.1 1.2 0.45 10.7 1.2 1.7 1 1 0 1 1 1 0 AAA domain Beta-Casp PF10996.8 EPA06775.1 - 3e-23 82.2 0.0 5.7e-23 81.3 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain KH_7 PF17214.3 EPA06775.1 - 2.3e-21 75.5 1.6 1e-20 73.4 0.8 2.5 3 0 0 3 3 3 1 KH domain RMMBL PF07521.12 EPA06775.1 - 6.7e-16 58.0 0.0 1.4e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 EPA06775.1 - 5.1e-14 52.2 0.0 9.5e-14 51.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EPA06775.1 - 4.5e-12 46.4 0.7 5.1e-11 42.9 0.2 2.5 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EPA06775.1 - 8.3e-09 35.2 0.0 2.3e-08 33.8 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EPA06775.1 - 0.011 15.6 0.0 0.035 14.0 0.0 1.9 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Copper-bind PF00127.20 EPA06776.1 - 0.014 15.8 0.7 0.097 13.1 0.0 2.4 2 0 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 EPA06776.1 - 0.04 14.0 0.0 0.14 12.3 0.0 2.0 1 1 0 1 1 1 0 Cupredoxin-like domain IF3_C PF00707.22 EPA06776.1 - 0.043 13.8 0.0 0.96 9.5 0.1 2.5 2 1 1 3 3 3 0 Translation initiation factor IF-3, C-terminal domain Creatinase_N PF01321.18 EPA06777.1 - 9.4e-14 52.2 0.0 1.1e-13 52.0 0.0 1.0 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain PGBA_N PF15436.6 EPA06777.1 - 0.013 15.2 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA N-terminal Pro_isomerase PF00160.21 EPA06778.1 - 2.2e-51 174.3 0.1 2.5e-51 174.1 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Allantoicase PF03561.15 EPA06779.1 - 0.00086 19.3 0.0 0.0021 18.1 0.0 1.5 1 0 0 1 1 1 1 Allantoicase repeat DUF5305 PF17231.2 EPA06779.1 - 0.0039 16.6 0.9 0.0084 15.5 0.2 1.9 2 0 0 2 2 2 1 Family of unknown function (DUF5305) Podoplanin PF05808.11 EPA06779.1 - 0.0062 16.7 1.0 0.0096 16.0 0.2 1.7 2 0 0 2 2 2 1 Podoplanin Glucos_trans_II PF14264.6 EPA06779.1 - 0.014 14.8 0.4 0.049 13.0 0.0 1.8 2 0 0 2 2 2 0 Glucosyl transferase GtrII DUF4064 PF13273.6 EPA06779.1 - 0.014 15.6 1.9 0.053 13.8 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) HSP20 PF00011.21 EPA06781.1 - 2.7e-13 49.9 0.2 3.4e-13 49.6 0.2 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EPA06781.1 - 1.8e-08 33.8 0.1 1.4e-07 30.9 0.1 2.4 2 1 1 3 3 3 1 HSP20-like domain found in ArsA TubC_N PF18563.1 EPA06781.1 - 0.015 15.3 0.2 0.051 13.6 0.0 1.8 2 0 0 2 2 2 0 TubC N-terminal docking domain DHQ_synthase PF01761.20 EPA06782.1 - 0.014 14.6 0.1 0.017 14.3 0.1 1.0 1 0 0 1 1 1 0 3-dehydroquinate synthase RTC PF01137.21 EPA06783.1 - 4.2e-76 255.0 0.1 4.9e-76 254.8 0.1 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase B-block_TFIIIC PF04182.12 EPA06783.1 - 0.062 13.5 0.1 0.19 11.9 0.1 1.8 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC HTH_23 PF13384.6 EPA06784.1 - 0.0063 16.3 0.0 0.01 15.6 0.0 1.5 1 1 0 1 1 1 1 Homeodomain-like domain HTH_IclR PF09339.10 EPA06784.1 - 0.046 13.5 0.0 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 IclR helix-turn-helix domain DUF5388 PF17363.2 EPA06784.1 - 0.055 13.7 0.1 0.092 13.0 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5388) CC190 PF15768.5 EPA06784.1 - 0.061 13.4 0.1 0.07 13.2 0.1 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 190 GntR PF00392.21 EPA06784.1 - 0.084 12.5 0.1 0.14 11.8 0.1 1.5 1 1 0 1 1 1 0 Bacterial regulatory proteins, gntR family LGT PF01790.18 EPA06785.1 - 0.033 13.4 0.7 0.033 13.4 0.7 1.0 1 0 0 1 1 1 0 Prolipoprotein diacylglyceryl transferase DnaJ_CXXCXGXG PF00684.19 EPA06786.1 - 0.002 18.5 7.8 0.0038 17.6 7.8 1.6 1 1 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EPA06786.1 - 0.039 13.9 6.4 0.26 11.3 1.5 3.0 2 1 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF5351 PF17302.2 EPA06786.1 - 0.4 10.9 9.2 0.76 10.0 4.1 2.9 2 1 0 2 2 2 0 Family of unknown function (DUF5351) zf-nanos PF05741.13 EPA06786.1 - 1.1 9.5 11.1 3.7 7.9 7.3 2.7 2 1 0 2 2 2 0 Nanos RNA binding domain LEA_2 PF03168.13 EPA06787.1 - 0.14 12.7 0.1 0.42 11.2 0.1 1.8 1 1 0 1 1 1 0 Late embryogenesis abundant protein PhoU PF01895.19 EPA06789.1 - 7.1e-09 36.0 4.1 3.9e-06 27.2 1.7 2.8 2 0 0 2 2 2 2 PhoU domain MazE_antitoxin PF04014.18 EPA06789.1 - 0.0018 18.2 0.0 0.0041 17.0 0.0 1.7 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin TP_methylase PF00590.20 EPA06790.1 - 3.6e-39 134.9 0.0 4.3e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Proteasome PF00227.26 EPA06792.1 - 3.4e-52 176.7 0.1 3.9e-52 176.5 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit Lipoprotein_15 PF03640.15 EPA06794.1 - 0.077 12.6 0.6 15 5.2 0.1 2.6 2 0 0 2 2 2 0 Secreted repeat of unknown function ATP-synt_D PF01813.17 EPA06795.1 - 2.6e-48 164.5 7.6 2.9e-48 164.3 7.6 1.0 1 0 0 1 1 1 1 ATP synthase subunit D CLU PF13236.6 EPA06795.1 - 0.053 13.3 0.0 0.081 12.8 0.0 1.3 1 0 0 1 1 1 0 Clustered mitochondria RNA_binding PF01877.17 EPA06795.1 - 0.097 13.0 6.2 1.8 8.8 0.9 2.2 2 0 0 2 2 2 0 RNA binding Nitroreductase PF00881.24 EPA06796.1 - 4.1e-24 85.5 0.0 7.2e-24 84.7 0.0 1.4 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 EPA06796.1 - 0.015 14.9 1.0 0.27 10.7 0.1 2.6 2 1 1 3 3 3 0 Putative TM nitroreductase ABC-3 PF00950.17 EPA06798.1 - 9.3e-65 218.7 37.5 1e-64 218.5 37.5 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.18 EPA06798.1 - 8.8e-07 28.2 39.3 3.8e-06 26.1 39.2 1.8 1 1 0 1 1 1 1 FecCD transport family Ammonium_transp PF00909.21 EPA06799.1 - 3.5e-108 361.9 33.8 9.7e-108 360.4 33.8 1.7 1 1 0 1 1 1 1 Ammonium Transporter Family IncF PF17626.2 EPA06799.1 - 0.032 14.6 1.0 0.1 13.0 1.0 1.9 1 0 0 1 1 1 0 Inclusion membrane protein F OTCace_N PF02729.21 EPA06801.1 - 9.2e-41 139.3 0.0 1.4e-40 138.7 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 EPA06801.1 - 4.2e-30 104.9 0.0 6e-30 104.4 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain FMN_red PF03358.15 EPA06802.1 - 1.2e-24 86.8 0.0 1.5e-24 86.5 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EPA06802.1 - 8.6e-09 35.4 0.0 1.1e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Rhomboid PF01694.22 EPA06803.1 - 8.4e-32 110.2 17.1 8.4e-32 110.2 17.1 1.5 2 0 0 2 2 2 1 Rhomboid family PyrI PF01948.18 EPA06804.1 - 1.3e-31 108.7 2.9 2e-31 108.1 2.9 1.3 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, allosteric domain PyrI_C PF02748.15 EPA06804.1 - 1.6e-14 53.5 1.5 3.2e-14 52.6 1.5 1.5 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain SUa-2TM PF18179.1 EPA06804.1 - 0.018 14.4 0.2 0.023 14.0 0.2 1.2 1 0 0 1 1 1 0 SMODS- and Ubiquitin system-associated 2TM effector domain DUF1936 PF09151.10 EPA06804.1 - 0.048 13.6 0.4 0.1 12.5 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1936) SepF PF04472.12 EPA06805.1 - 3.1e-11 43.4 0.5 3.5e-11 43.2 0.5 1.0 1 0 0 1 1 1 1 Cell division protein SepF SporV_AA PF12164.8 EPA06805.1 - 0.023 15.0 0.7 0.034 14.5 0.7 1.2 1 0 0 1 1 1 0 Stage V sporulation protein AA Herpes_IE68 PF02479.16 EPA06805.1 - 0.024 14.2 0.0 0.027 14.1 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus immediate early protein H_kinase_N PF12282.8 EPA06805.1 - 0.036 14.0 0.0 0.055 13.4 0.0 1.2 1 0 0 1 1 1 0 Signal transduction histidine kinase ATP-synt_ab PF00006.25 EPA06807.1 - 1.4e-70 237.3 0.0 1.9e-70 236.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EPA06807.1 - 6.5e-12 45.8 2.5 1.5e-11 44.6 2.5 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 EPA06807.1 - 0.00031 20.8 0.5 0.0016 18.5 0.4 2.3 2 0 0 2 2 2 1 HAS barrel domain HTH_24 PF13412.6 EPA06808.1 - 1.8e-18 65.8 9.6 1.2e-10 40.7 1.6 2.6 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 EPA06808.1 - 5.2e-18 64.6 0.5 7.1e-12 45.0 0.1 2.4 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain MarR PF01047.22 EPA06808.1 - 1.2e-06 28.3 2.0 0.00082 19.2 0.4 2.5 2 0 0 2 2 2 2 MarR family TrmB PF01978.19 EPA06808.1 - 1.9e-06 27.7 0.1 0.05 13.5 0.0 2.3 2 0 0 2 2 2 2 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 EPA06808.1 - 9.9e-05 22.2 3.0 0.062 13.3 0.3 2.8 2 0 0 2 2 2 2 HTH domain MarR_2 PF12802.7 EPA06808.1 - 0.00041 20.2 0.0 0.43 10.5 0.0 2.3 2 0 0 2 2 2 2 MarR family Mga PF05043.13 EPA06808.1 - 0.0011 19.5 0.2 0.16 12.6 0.1 2.7 2 0 0 2 2 2 1 Mga helix-turn-helix domain Trp_repressor PF01371.19 EPA06808.1 - 0.0062 16.6 1.3 0.066 13.3 0.1 2.7 3 0 0 3 3 3 1 Trp repressor protein HTH_5 PF01022.20 EPA06808.1 - 0.0073 16.1 1.1 0.039 13.8 0.2 2.4 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_23 PF13384.6 EPA06808.1 - 0.012 15.3 0.0 0.99 9.3 0.0 2.6 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Mga PF08280.11 EPA06808.1 - 0.02 14.9 3.7 0.02 14.9 3.7 3.4 3 0 0 3 3 3 0 M protein trans-acting positive regulator (MGA) HTH domain DUF1366 PF07104.11 EPA06808.1 - 0.04 13.6 0.4 0.04 13.6 0.4 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF1366) DUF4423 PF14394.6 EPA06808.1 - 0.042 13.5 0.3 8.4 6.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4423) HTH_34 PF13601.6 EPA06808.1 - 0.045 13.9 0.0 14 6.0 0.0 2.4 2 0 0 2 2 2 0 Winged helix DNA-binding domain TFIIE_alpha PF02002.17 EPA06808.1 - 0.061 13.2 1.7 3.1 7.7 0.2 2.5 2 0 0 2 2 2 0 TFIIE alpha subunit GerE PF00196.19 EPA06808.1 - 0.063 12.8 4.3 5.5 6.6 0.3 3.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, luxR family GAIN_A PF18619.1 EPA06808.1 - 0.19 12.0 1.5 4.2 7.6 0.2 2.4 2 0 0 2 2 2 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A LON_substr_bdg PF02190.16 EPA06809.1 - 4.3e-20 72.5 0.1 5e-20 72.3 0.1 1.1 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain Pantoate_transf PF02548.15 EPA06810.1 - 3.8e-108 360.8 2.2 4.3e-108 360.6 2.2 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 EPA06810.1 - 0.008 15.7 0.3 0.026 14.0 0.2 1.9 1 1 1 2 2 2 1 Phosphoenolpyruvate phosphomutase vATP-synt_AC39 PF01992.16 EPA06811.1 - 3.3e-52 178.0 6.4 4.4e-52 177.7 6.4 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Fibritin_C PF07921.12 EPA06811.1 - 0.035 14.2 0.1 0.17 12.0 0.0 2.1 2 0 0 2 2 2 0 Fibritin C-terminal region ATP-synt_ab PF00006.25 EPA06812.1 - 8.1e-93 309.9 0.0 1.1e-92 309.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EPA06812.1 - 1.9e-38 131.0 0.0 3.3e-38 130.3 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EPA06812.1 - 5.9e-14 52.3 0.6 1.4e-13 51.1 0.6 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_22 PF13401.6 EPA06812.1 - 0.048 13.9 0.3 0.12 12.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF853 PF05872.12 EPA06812.1 - 0.11 11.0 0.2 0.18 10.4 0.2 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) tRNA-synt_1b PF00579.25 EPA06813.1 - 2.1e-42 145.5 0.1 2.6e-42 145.2 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Not3 PF04065.15 EPA06813.1 - 0.062 12.7 0.9 0.086 12.3 0.9 1.2 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component DUF4092 PF13322.6 EPA06813.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4092) Multi_Drug_Res PF00893.19 EPA06814.1 - 0.0069 17.0 1.4 0.0073 17.0 1.4 1.1 1 0 0 1 1 1 1 Small Multidrug Resistance protein ABC1 PF03109.16 EPA06815.1 - 2.8e-23 82.3 0.0 1.1e-22 80.4 0.0 1.9 2 0 0 2 2 2 1 ABC1 family APH PF01636.23 EPA06815.1 - 0.029 14.3 0.0 0.058 13.3 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EPA06815.1 - 0.064 12.6 0.4 0.12 11.7 0.4 1.5 1 0 0 1 1 1 0 Protein kinase domain CesT PF05932.13 EPA06815.1 - 0.1 12.7 0.0 0.28 11.3 0.0 1.7 2 0 0 2 2 2 0 Tir chaperone protein (CesT) family CBS PF00571.28 EPA06816.1 - 2.1e-43 146.5 7.3 2.8e-11 43.7 0.1 4.1 4 0 0 4 4 4 4 CBS domain Sigma54_DBD PF04552.13 EPA06816.1 - 0.025 14.3 0.0 0.055 13.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-54, DNA binding domain SIR2 PF02146.17 EPA06817.1 - 3.6e-53 180.1 0.0 4.4e-53 179.8 0.0 1.1 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 EPA06817.1 - 0.056 13.2 0.0 6.8 6.4 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Ldh_1_N PF00056.23 EPA06818.1 - 1.5e-23 83.5 1.3 2.7e-23 82.6 1.3 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EPA06818.1 - 1.7e-21 76.9 0.4 4.2e-21 75.6 0.1 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 EPA06818.1 - 2.4e-06 27.2 0.3 1.2e-05 25.0 0.1 2.1 1 1 1 2 2 2 1 Family 4 glycosyl hydrolase Shikimate_DH PF01488.20 EPA06818.1 - 0.0033 17.5 1.5 0.0051 16.9 0.4 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.23 EPA06818.1 - 0.0035 17.3 0.2 0.011 15.7 0.2 2.0 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 EPA06818.1 - 0.011 16.3 0.3 0.04 14.5 0.2 2.1 1 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent LPD3 PF18798.1 EPA06818.1 - 0.034 14.4 0.8 0.9 9.8 0.2 2.5 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 3 Sacchrp_dh_NADP PF03435.18 EPA06818.1 - 0.079 13.2 0.1 0.25 11.6 0.1 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain AA_permease_2 PF13520.6 EPA06820.1 - 9.7e-50 169.6 61.1 2e-49 168.6 61.5 1.3 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EPA06820.1 - 5.3e-42 144.0 53.9 8.5e-42 143.3 53.9 1.3 1 1 0 1 1 1 1 Amino acid permease Spore_permease PF03845.13 EPA06820.1 - 6.7e-06 25.1 23.9 6.7e-06 25.1 23.9 2.7 1 1 1 2 2 2 1 Spore germination protein TMEM223 PF14640.6 EPA06820.1 - 0.55 10.4 5.6 0.12 12.5 0.6 2.3 2 0 0 2 2 2 0 Transmembrane protein 223 AsnC_trans_reg PF01037.21 EPA06821.1 - 5.1e-08 32.8 0.1 5.3e-08 32.7 0.1 1.1 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain UPF0020 PF01170.18 EPA06823.1 - 1.5e-19 70.5 0.2 1.3e-18 67.4 0.2 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 EPA06823.1 - 2.4e-11 43.8 0.0 1.3e-09 38.1 0.1 2.1 2 0 0 2 2 2 1 DNA methylase Methyltransf_31 PF13847.6 EPA06823.1 - 5.4e-10 39.3 0.0 5.8e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EPA06823.1 - 4.8e-09 36.8 0.0 5.6e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EPA06823.1 - 2.3e-06 27.4 0.0 2.7e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 EPA06823.1 - 8.9e-06 26.3 0.0 1e-05 26.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.16 EPA06823.1 - 5.4e-05 22.6 0.0 7e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase AviRa PF11599.8 EPA06823.1 - 0.00011 21.8 0.0 0.015 14.7 0.0 2.1 1 1 1 2 2 2 2 RRNA methyltransferase AviRa Methyltransf_5 PF01795.19 EPA06823.1 - 0.00013 21.6 0.0 0.00013 21.5 0.0 1.2 1 0 0 1 1 1 1 MraW methylase family Methyltransf_15 PF09445.10 EPA06823.1 - 0.00028 20.5 0.0 0.00034 20.2 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 EPA06823.1 - 0.00068 19.1 0.0 0.00088 18.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.16 EPA06823.1 - 0.0011 18.8 0.0 0.0011 18.7 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 EPA06823.1 - 0.0011 18.5 0.0 0.0011 18.5 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EPA06823.1 - 0.0027 17.1 0.0 0.0027 17.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MethyltransfD12 PF02086.15 EPA06823.1 - 0.01 15.6 0.0 0.011 15.4 0.0 1.3 1 1 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Ubie_methyltran PF01209.18 EPA06823.1 - 0.014 14.8 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EPA06823.1 - 0.042 14.6 0.0 0.051 14.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Lactamase_B_2 PF12706.7 EPA06824.1 - 1.7e-15 57.1 0.0 1.2e-06 28.2 0.0 2.1 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EPA06824.1 - 8.6e-08 32.4 0.0 5.2e-07 29.9 0.0 2.2 3 0 0 3 3 3 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 EPA06824.1 - 0.00034 20.2 0.0 0.00073 19.2 0.0 1.5 1 0 0 1 1 1 1 tRNase Z endonuclease DnaJ PF00226.31 EPA06825.1 - 9.8e-12 44.8 0.1 1.1e-10 41.4 0.0 2.4 2 0 0 2 2 2 1 DnaJ domain P-II PF00543.22 EPA06826.1 - 4.6e-19 68.9 4.4 5.4e-19 68.7 4.4 1.1 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DSPc PF00782.20 EPA06828.1 - 1.2e-16 60.7 0.0 1.5e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EPA06828.1 - 1.7e-08 34.3 0.3 6.2e-08 32.5 0.0 1.7 1 1 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EPA06828.1 - 5e-07 30.0 0.0 7.5e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate CDKN3 PF05706.12 EPA06828.1 - 0.0016 18.1 0.0 0.0023 17.6 0.0 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 EPA06828.1 - 0.0069 16.4 0.0 0.0087 16.0 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family UDPG_MGDP_dh_N PF03721.14 EPA06828.1 - 0.028 14.0 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GDH_N PF12466.8 EPA06828.1 - 0.045 13.9 0.0 0.071 13.3 0.0 1.3 1 0 0 1 1 1 0 Glutamate dehydrogenase N terminal Rhodanese PF00581.20 EPA06828.1 - 0.08 13.5 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 Rhodanese-like domain Y_phosphatase2 PF03162.13 EPA06828.1 - 0.099 12.2 0.0 0.17 11.4 0.0 1.4 1 1 0 1 1 1 0 Tyrosine phosphatase family THUMP PF02926.17 EPA06830.1 - 0.00057 20.0 0.1 0.0011 19.0 0.1 1.7 1 1 0 1 1 1 1 THUMP domain HTH_IclR PF09339.10 EPA06831.1 - 3.8e-05 23.4 0.0 6.1e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_20 PF12840.7 EPA06831.1 - 0.00052 20.0 0.0 0.00073 19.5 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 EPA06831.1 - 0.00064 19.6 0.0 0.00087 19.1 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB DUF742 PF05331.11 EPA06831.1 - 0.0082 15.9 0.0 0.01 15.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF742) Hpr_kinase_N PF02603.16 EPA06831.1 - 0.024 14.7 0.1 0.032 14.2 0.1 1.2 1 0 0 1 1 1 0 HPr Serine kinase N terminus FUR PF01475.19 EPA06831.1 - 0.027 14.6 0.0 0.029 14.5 0.0 1.3 1 0 0 1 1 1 0 Ferric uptake regulator family HTH_5 PF01022.20 EPA06831.1 - 0.03 14.2 0.0 0.049 13.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family DND1_DSRM PF14709.7 EPA06831.1 - 0.063 13.5 0.1 0.19 12.0 0.0 1.7 2 0 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 HTH_24 PF13412.6 EPA06831.1 - 0.077 12.6 0.0 0.18 11.4 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF2857 PF11198.8 EPA06831.1 - 0.084 12.7 0.0 0.1 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2857) Radical_SAM PF04055.21 EPA06833.1 - 4.5e-13 49.9 0.4 1.8e-12 48.0 0.0 2.1 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 EPA06833.1 - 0.0061 16.8 0.9 0.017 15.4 0.0 2.1 2 0 0 2 2 2 1 4Fe-4S single cluster domain DUF3419 PF11899.8 EPA06833.1 - 0.017 14.3 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3419) zf-ribbon_3 PF13248.6 EPA06833.1 - 3.6 7.1 15.1 0.83 9.2 0.2 3.7 4 0 0 4 4 4 0 zinc-ribbon domain zf-piccolo PF05715.13 EPA06833.1 - 5.5 7.2 9.9 16 5.7 0.9 3.5 3 1 1 4 4 4 0 Piccolo Zn-finger PCNA_N PF00705.18 EPA06834.1 - 7.6e-20 70.9 0.1 1.4e-19 70.1 0.1 1.3 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EPA06834.1 - 2.7e-18 66.4 0.6 1.1e-16 61.2 0.0 2.7 2 1 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 EPA06834.1 - 5e-07 29.0 0.1 0.012 14.6 0.0 2.2 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 EPA06834.1 - 0.0051 16.3 0.0 0.0062 16.0 0.0 1.1 1 0 0 1 1 1 1 Rad9 Receptor_2B4 PF11465.8 EPA06834.1 - 0.06 13.5 0.1 0.14 12.4 0.1 1.7 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 CBS PF00571.28 EPA06835.1 - 4.5e-43 145.5 8.9 3.3e-12 46.7 0.2 4.1 4 0 0 4 4 4 4 CBS domain LAMTOR5 PF16672.5 EPA06835.1 - 0.012 15.5 0.4 0.62 10.0 0.0 2.9 3 0 0 3 3 3 0 Ragulator complex protein LAMTOR5 IF3_N PF05198.16 EPA06835.1 - 0.04 14.2 1.3 11 6.4 0.0 3.5 3 0 0 3 3 3 0 Translation initiation factor IF-3, N-terminal domain Peptidase_S7 PF00949.21 EPA06835.1 - 0.15 11.9 2.5 3.2 7.6 0.2 2.7 2 0 0 2 2 2 0 Peptidase S7, Flavivirus NS3 serine protease UPF0113 PF03657.13 EPA06835.1 - 0.28 11.5 6.3 24 5.3 0.0 4.2 3 2 0 3 3 3 0 UPF0113 PUA domain Fer4 PF00037.27 EPA06836.1 - 2e-11 43.2 10.6 5.1e-07 29.3 0.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EPA06836.1 - 6.9e-09 36.2 3.7 9.8e-09 35.7 3.7 1.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EPA06836.1 - 3.5e-08 33.2 8.1 0.0013 18.7 0.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 EPA06836.1 - 4.5e-08 33.1 1.8 6.4e-08 32.6 1.8 1.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 EPA06836.1 - 4.4e-06 26.8 4.1 1.8e-05 24.8 4.2 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 EPA06836.1 - 1.5e-05 24.8 7.8 0.018 15.1 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 EPA06836.1 - 7.9e-05 23.1 4.2 0.12 12.9 0.5 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_10 PF13237.6 EPA06836.1 - 0.00014 21.9 8.3 0.0054 16.8 9.2 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 EPA06836.1 - 0.00025 21.3 6.9 0.081 13.5 2.0 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 EPA06836.1 - 0.00027 21.8 5.4 0.075 14.0 0.1 2.1 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_3 PF12798.7 EPA06836.1 - 0.0013 19.5 11.2 0.097 13.7 3.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_22 PF17179.4 EPA06836.1 - 0.0019 19.0 3.8 0.3 12.0 0.9 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 EPA06836.1 - 0.0052 17.2 5.8 0.048 14.1 5.8 2.0 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 EPA06836.1 - 0.031 14.8 6.7 1 9.9 6.8 2.1 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_15 PF13459.6 EPA06836.1 - 0.08 13.7 10.7 0.51 11.1 2.1 2.8 1 1 1 2 2 2 0 4Fe-4S single cluster domain Fer4_18 PF13746.6 EPA06836.1 - 0.7 10.1 10.3 1.8 8.8 3.1 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain Pribosyltran_N PF13793.6 EPA06837.1 - 6.9e-29 100.1 0.3 2e-28 98.7 0.1 1.8 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EPA06837.1 - 1.7e-19 69.9 2.2 2e-19 69.7 0.5 1.9 2 1 0 2 2 2 1 Phosphoribosyl transferase domain Pribosyl_synth PF14572.6 EPA06837.1 - 1.7e-14 54.3 1.6 1e-12 48.5 0.5 2.9 2 1 1 3 3 3 1 Phosphoribosyl synthetase-associated domain UPRTase PF14681.6 EPA06837.1 - 0.00013 21.5 0.1 0.0003 20.3 0.0 1.6 2 0 0 2 2 2 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 EPA06837.1 - 0.0035 16.9 0.1 0.0072 15.9 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase Asp_Glu_race PF01177.22 EPA06837.1 - 0.007 16.2 0.0 0.042 13.7 0.0 2.0 2 0 0 2 2 2 1 Asp/Glu/Hydantoin racemase Cu PF17563.2 EPA06837.1 - 2.8 8.2 6.2 2.8 8.2 3.5 2.4 2 0 0 2 2 2 0 Cupiennin TFIIS_C PF01096.18 EPA06838.1 - 1.1e-19 70.0 5.9 1.1e-19 70.0 5.9 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) DZR PF12773.7 EPA06838.1 - 0.0004 20.3 9.4 0.014 15.4 1.7 2.5 2 1 0 2 2 2 2 Double zinc ribbon RNA_POL_M_15KD PF02150.16 EPA06838.1 - 0.00058 19.7 15.8 0.21 11.5 5.9 3.6 2 2 1 3 3 3 2 RNA polymerases M/15 Kd subunit zinc_ribbon_4 PF13717.6 EPA06838.1 - 0.0072 16.2 15.0 0.65 10.0 0.4 4.1 3 1 0 3 3 3 1 zinc-ribbon domain Prok-RING_1 PF14446.6 EPA06838.1 - 0.025 14.5 1.3 0.025 14.5 1.3 2.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Zn_Tnp_IS1595 PF12760.7 EPA06838.1 - 0.08 12.9 15.3 0.076 13.0 3.2 3.4 2 2 1 3 3 3 0 Transposase zinc-ribbon domain zf-RRPl_C4 PF17026.5 EPA06838.1 - 0.099 12.7 7.4 0.15 12.2 7.4 1.3 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-NADH-PPase PF09297.11 EPA06838.1 - 0.14 11.9 10.1 0.11 12.2 2.2 3.7 3 1 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain Baculo_LEF5_C PF11792.8 EPA06838.1 - 0.17 11.6 0.0 0.17 11.6 0.0 2.9 3 0 0 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain zf-H2C2_2 PF13465.6 EPA06838.1 - 0.25 11.9 15.5 2.3 8.8 0.6 4.0 3 1 1 4 4 4 0 Zinc-finger double domain C1_1 PF00130.22 EPA06838.1 - 0.25 11.3 9.5 0.79 9.7 1.2 2.7 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) A2L_zn_ribbon PF08792.10 EPA06838.1 - 0.3 10.8 12.9 0.91 9.3 0.2 3.9 3 1 0 4 4 4 0 A2L zinc ribbon domain zinc-ribbons_6 PF07191.12 EPA06838.1 - 0.35 10.9 11.7 1.5e+02 2.4 11.7 2.8 1 1 0 1 1 1 0 zinc-ribbons C1_2 PF03107.16 EPA06838.1 - 0.37 11.2 14.0 4.1 7.8 1.4 2.9 2 1 0 2 2 2 0 C1 domain zinc_ribbon_2 PF13240.6 EPA06838.1 - 0.58 9.9 15.9 13 5.6 0.1 4.0 3 1 0 3 3 3 0 zinc-ribbon domain Ribosomal_L44 PF00935.19 EPA06838.1 - 0.79 10.2 7.6 19 5.8 0.8 3.1 3 0 0 3 3 3 0 Ribosomal protein L44 DUF3795 PF12675.7 EPA06838.1 - 0.99 9.9 10.9 0.18 12.2 6.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3795) C1_4 PF07975.12 EPA06838.1 - 1.1 9.6 12.4 4.3 7.7 0.6 3.5 2 2 0 3 3 3 0 TFIIH C1-like domain IBR PF01485.21 EPA06838.1 - 1.3 9.3 12.9 4.8 7.5 2.8 3.0 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Zn_Tnp_IS1 PF03811.13 EPA06838.1 - 1.7 8.4 12.1 13 5.7 3.4 3.9 3 1 0 3 3 3 0 InsA N-terminal domain HypA PF01155.19 EPA06838.1 - 2.3 8.3 12.1 3.6 7.6 2.5 2.6 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA OrfB_Zn_ribbon PF07282.11 EPA06838.1 - 2.5 8.1 12.6 0.84 9.6 1.4 3.0 1 1 0 2 2 2 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.6 EPA06838.1 - 6 6.4 17.5 33 4.1 5.9 4.1 3 1 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_15 PF17032.5 EPA06838.1 - 7.8 7.3 16.9 7.8e+02 0.9 16.9 2.8 1 1 0 1 1 1 0 zinc-ribbon family Zn-ribbon_8 PF09723.10 EPA06838.1 - 7.9 6.7 15.1 8.5 6.6 0.0 4.2 3 1 1 4 4 4 0 Zinc ribbon domain DnaJ_CXXCXGXG PF00684.19 EPA06838.1 - 8 6.9 11.3 1.6e+02 2.7 11.3 2.4 1 1 0 1 1 1 0 DnaJ central domain zf-TFIIB PF13453.6 EPA06838.1 - 8.3 5.8 15.0 5.5 6.4 3.4 3.6 2 2 1 3 3 3 0 Transcription factor zinc-finger Elong_Iki1 PF10483.9 EPA06840.1 - 0.0094 15.5 0.1 0.012 15.1 0.1 1.1 1 0 0 1 1 1 1 Elongator subunit Iki1 Alpha_L_fucos PF01120.17 EPA06840.1 - 0.055 12.9 0.0 0.069 12.6 0.0 1.1 1 0 0 1 1 1 0 Alpha-L-fucosidase HAMP PF00672.25 EPA06841.1 - 8.3e-14 51.7 0.0 1.4e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 HAMP domain dCache_1 PF02743.18 EPA06841.1 - 2e-12 47.4 0.2 4.1e-12 46.4 0.2 1.5 1 0 0 1 1 1 1 Cache domain Guanylate_cyc PF00211.20 EPA06841.1 - 1.1e-09 38.2 0.1 3e-09 36.8 0.0 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Aminotran_5 PF00266.19 EPA06842.1 - 2.8e-68 230.6 0.0 3.3e-68 230.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EPA06842.1 - 3.2e-07 29.8 0.0 4.8e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II YgbB PF02542.16 EPA06842.1 - 0.07 13.4 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 YgbB family EF-hand_1 PF00036.32 EPA06842.1 - 0.12 12.0 0.6 0.31 10.7 0.6 1.7 1 0 0 1 1 1 0 EF hand Beta_elim_lyase PF01212.21 EPA06842.1 - 0.24 10.7 0.0 1.1 8.5 0.0 1.8 1 1 0 1 1 1 0 Beta-eliminating lyase Usp PF00582.26 EPA06843.1 - 8.7e-28 97.6 0.3 1e-27 97.4 0.3 1.1 1 0 0 1 1 1 1 Universal stress protein family Na_Ca_ex PF01699.24 EPA06844.1 - 2.6e-45 154.1 40.5 5.1e-27 94.7 16.9 2.0 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Flavi_M PF01004.19 EPA06844.1 - 0.14 11.9 1.6 15 5.5 0.1 3.3 2 0 0 2 2 2 0 Flavivirus envelope glycoprotein M FixQ PF05545.11 EPA06844.1 - 0.15 12.0 0.1 0.15 12.0 0.1 3.8 4 0 0 4 4 4 0 Cbb3-type cytochrome oxidase component FixQ Usp PF00582.26 EPA06845.1 - 3.5e-30 105.4 0.0 4.2e-30 105.1 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family DUF3880 PF12996.7 EPA06845.1 - 0.023 14.8 0.0 0.031 14.4 0.0 1.3 1 0 0 1 1 1 0 DUF based on E. rectale Gene description (DUF3880) Cyclase PF04199.13 EPA06846.1 - 9.4e-32 110.1 0.0 1.2e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 Putative cyclase Copper-bind PF00127.20 EPA06847.1 - 1.7e-07 31.6 0.0 3.9e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 EPA06847.1 - 0.013 15.6 0.1 0.22 11.7 0.0 3.1 4 1 0 4 4 4 0 Cupredoxin-like domain DUF4064 PF13273.6 EPA06847.1 - 0.026 14.8 0.3 0.08 13.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Phage_integr_3 PF16795.5 EPA06849.1 - 1.3e-10 41.4 0.5 2e-10 40.8 0.5 1.3 1 0 0 1 1 1 1 Archaeal phage integrase HYR PF02494.16 EPA06850.1 - 7.1e-11 42.3 0.6 7.1e-11 42.3 0.6 2.4 3 0 0 3 3 3 1 HYR domain Copper-bind PF00127.20 EPA06850.1 - 2.2e-07 31.3 0.0 1.1e-06 28.9 0.0 2.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 EPA06850.1 - 7.6e-05 22.8 0.1 0.00035 20.7 0.0 2.2 2 0 0 2 2 2 1 Cupredoxin-like domain DUF5643 PF18705.1 EPA06850.1 - 9.9e-05 22.3 4.2 0.0024 17.8 0.5 3.6 3 0 0 3 3 3 1 Family of unknown function (DUF5643) DUF4352 PF11611.8 EPA06850.1 - 0.00049 20.4 0.6 0.0038 17.5 0.0 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF4352) DUF5067 PF16729.5 EPA06850.1 - 0.083 12.8 0.1 0.083 12.8 0.1 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF5067) ATG16 PF08614.11 EPA06851.1 - 0.017 15.3 0.1 0.021 15.1 0.1 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Asp_Glu_race PF01177.22 EPA06853.1 - 9.5e-12 45.2 0.0 1.4e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase Redoxin PF08534.10 EPA06853.1 - 0.028 14.1 0.0 0.062 13.0 0.0 1.5 1 0 0 1 1 1 0 Redoxin LAX PF15681.5 EPA06853.1 - 0.17 10.7 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 Lymphocyte activation family X DUF2072 PF09845.9 EPA06855.1 - 0.048 13.9 0.1 0.053 13.8 0.1 1.0 1 0 0 1 1 1 0 Zn-ribbon containing protein HNH PF01844.23 EPA06856.1 - 0.0071 16.5 6.3 11 6.2 0.2 4.2 4 0 0 4 4 4 3 HNH endonuclease HemolysinCabind PF00353.19 EPA06857.1 - 5.5e-31 106.1 97.8 4e-10 39.5 12.3 5.9 2 1 4 6 6 6 5 RTX calcium-binding nonapeptide repeat (4 copies) Big_9 PF17963.1 EPA06857.1 - 1.4e-07 32.1 2.0 1.4e-07 32.1 2.0 2.4 2 0 0 2 2 2 1 Bacterial Ig domain Cu-binding_MopE PF11617.8 EPA06857.1 - 2.5e-06 27.5 7.3 2.4e-05 24.4 7.3 2.9 1 0 0 1 1 1 1 Putative metal-binding motif Cadherin_5 PF17892.1 EPA06857.1 - 6.7e-06 26.0 0.2 6.7e-06 26.0 0.2 2.0 3 0 0 3 3 3 1 Cadherin-like domain Collagen PF01391.18 EPA06857.1 - 0.026 14.3 13.8 1.7 8.5 6.6 2.6 1 1 1 2 2 2 0 Collagen triple helix repeat (20 copies) HGTP_anticodon PF03129.20 EPA06858.1 - 1e-17 64.1 0.2 2.5e-17 62.8 0.2 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EPA06858.1 - 4.2e-12 46.4 0.8 5.7e-11 42.7 0.5 2.4 2 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) zf-RRPl_C4 PF17026.5 EPA06858.1 - 0.14 12.2 0.7 0.66 10.1 0.2 2.3 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-TFIIB PF13453.6 EPA06858.1 - 0.18 11.2 0.8 6 6.3 0.1 2.6 2 0 0 2 2 2 0 Transcription factor zinc-finger zinc_ribbon_15 PF17032.5 EPA06858.1 - 0.25 12.1 2.5 0.54 11.0 1.0 2.2 2 1 1 3 3 3 0 zinc-ribbon family zinc_ribbon_5 PF13719.6 EPA06858.1 - 0.54 10.1 6.9 1.5 8.7 1.0 3.0 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_4 PF13717.6 EPA06858.1 - 0.71 9.8 3.9 16 5.5 0.4 2.8 2 0 0 2 2 2 0 zinc-ribbon domain DUF3172 PF11371.8 EPA06859.1 - 0.046 13.4 0.2 0.096 12.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3172) DUF1769 PF08588.10 EPA06859.1 - 0.067 13.4 0.0 0.32 11.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1769) PD40 PF07676.12 EPA06859.1 - 0.27 11.2 1.0 14 5.7 0.1 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Tetraspanin PF00335.20 EPA06861.1 - 0.74 9.5 4.0 5.2 6.7 0.1 2.3 1 1 1 2 2 2 0 Tetraspanin family TrmB PF01978.19 EPA06862.1 - 2e-06 27.6 0.2 2.8e-06 27.1 0.2 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 EPA06862.1 - 5.4e-05 22.7 1.1 0.00017 21.1 1.1 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 EPA06862.1 - 7.9e-05 22.6 0.0 0.00012 22.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_IclR PF09339.10 EPA06862.1 - 0.00072 19.3 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_5 PF01022.20 EPA06862.1 - 0.0016 18.2 0.5 0.0024 17.7 0.5 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family DUF1492 PF07374.11 EPA06862.1 - 0.0016 18.5 0.3 0.0035 17.5 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1492) HTH_11 PF08279.12 EPA06862.1 - 0.0032 17.4 0.9 0.0054 16.6 0.9 1.5 1 1 0 1 1 1 1 HTH domain HTH_23 PF13384.6 EPA06862.1 - 0.0033 17.2 0.0 0.014 15.2 0.0 1.9 1 1 1 2 2 2 1 Homeodomain-like domain MarR_2 PF12802.7 EPA06862.1 - 0.0084 16.0 0.0 0.012 15.5 0.0 1.2 1 0 0 1 1 1 1 MarR family PriX PF18689.1 EPA06862.1 - 0.0095 16.3 2.2 0.019 15.3 1.4 1.7 1 1 0 1 1 1 1 Primase X Mga PF05043.13 EPA06862.1 - 0.018 15.6 0.2 0.031 14.8 0.2 1.4 1 1 0 1 1 1 0 Mga helix-turn-helix domain Sigma70_r4 PF04545.16 EPA06862.1 - 0.03 13.8 0.0 0.055 13.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 FUR PF01475.19 EPA06862.1 - 0.043 14.0 0.1 0.06 13.5 0.1 1.4 1 0 0 1 1 1 0 Ferric uptake regulator family HTH_8 PF02954.19 EPA06862.1 - 0.076 12.8 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_Crp_2 PF13545.6 EPA06862.1 - 0.12 12.4 0.3 0.17 11.9 0.3 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Peptidase_S8 PF00082.22 EPA06863.1 - 6.4e-18 65.0 0.1 1.2e-17 64.2 0.1 1.3 1 0 0 1 1 1 1 Subtilase family SH3_3 PF08239.11 EPA06865.1 - 0.00053 20.2 0.0 0.0017 18.6 0.0 1.9 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_9 PF14604.6 EPA06865.1 - 0.0049 16.7 0.2 0.01 15.6 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain UPF0102 PF02021.17 EPA06865.1 - 0.021 15.1 0.0 0.054 13.7 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0102 RE_Bpu10I PF09549.10 EPA06865.1 - 0.055 13.1 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Bpu10I restriction endonuclease FACT-Spt16_Nlob PF14826.6 EPA06865.1 - 0.073 12.9 7.6 0.015 15.1 2.7 2.1 2 0 0 2 2 2 0 FACT complex subunit SPT16 N-terminal lobe domain GvpG PF05120.12 EPA06867.1 - 0.02 14.9 1.7 4.3 7.4 0.3 3.0 2 0 0 2 2 2 0 Gas vesicle protein G Trypan_PARP PF05887.11 EPA06867.1 - 0.02 14.9 1.9 0.038 14.0 1.9 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DEC-1_N PF04625.13 EPA06867.1 - 0.061 12.3 1.0 0.16 10.9 1.0 1.7 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region UBA_3 PF09288.10 EPA06868.1 - 0.0043 16.8 0.1 0.011 15.6 0.1 1.7 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Endopep_inhib PF16800.5 EPA06868.1 - 0.35 10.8 5.8 0.15 12.0 2.4 1.9 1 1 1 2 2 2 0 IseA DL-endopeptidase inhibitor DUF5615 PF18480.1 EPA06869.1 - 0.0042 16.8 0.0 0.0056 16.4 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF5615) Phage_integrase PF00589.22 EPA06870.1 - 8.9e-05 22.3 0.1 0.0075 16.1 0.0 3.3 2 1 0 2 2 2 1 Phage integrase family MUG113 PF13455.6 EPA06871.1 - 2.2e-08 34.7 0.0 4e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 EPA06871.1 - 5.2e-07 30.2 0.0 1.1e-06 29.2 0.0 1.5 1 0 0 1 1 1 1 T5orf172 domain MmcB-like PF06319.12 EPA06872.1 - 0.0011 18.6 0.1 0.0014 18.3 0.1 1.2 1 0 0 1 1 1 1 DNA repair protein MmcB-like Hjc PF01870.18 EPA06872.1 - 0.013 15.5 0.0 0.029 14.4 0.0 1.7 2 0 0 2 2 2 0 Archaeal holliday junction resolvase (hjc) UPF0102 PF02021.17 EPA06872.1 - 0.016 15.4 0.0 0.096 12.9 0.0 2.1 1 1 1 2 2 2 0 Uncharacterised protein family UPF0102 AHJR-like PF18743.1 EPA06872.1 - 0.026 14.1 0.6 0.074 12.6 0.1 2.0 2 1 0 2 2 2 0 REase_AHJR-like NERD PF08378.11 EPA06872.1 - 0.058 13.9 0.3 0.1 13.1 0.1 1.8 1 1 0 1 1 1 0 Nuclease-related domain VRR_NUC PF08774.11 EPA06872.1 - 0.062 13.4 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 VRR-NUC domain Methyltransf_25 PF13649.6 EPA06873.1 - 1.1e-09 38.9 0.1 1.6e-09 38.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EPA06873.1 - 4.4e-09 37.0 0.2 6.6e-09 36.4 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EPA06873.1 - 4.2e-08 33.1 0.3 5.8e-08 32.7 0.3 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EPA06873.1 - 5.6e-08 33.3 0.0 9e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 EPA06873.1 - 6.1e-08 32.4 1.4 0.0076 15.7 0.0 2.6 2 1 1 3 3 3 2 CheR methyltransferase, SAM binding domain Methyltransf_23 PF13489.6 EPA06873.1 - 0.00014 21.7 0.0 0.00018 21.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EPA06873.1 - 0.00092 19.2 0.5 0.0015 18.4 0.5 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EPA06873.1 - 0.0012 18.3 0.3 0.01 15.3 0.2 2.3 3 0 0 3 3 3 1 Putative methyltransferase RnlB_antitoxin PF15933.5 EPA06873.1 - 0.0045 17.3 1.1 0.032 14.5 0.8 2.3 3 0 0 3 3 3 1 Antitoxin to bacterial toxin RNase LS or RnlA Methyltransf_32 PF13679.6 EPA06873.1 - 0.011 15.7 0.1 0.021 14.8 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 EPA06873.1 - 0.043 13.9 0.2 0.078 13.1 0.2 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 EPA06873.1 - 0.085 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Topoisom_I PF01028.20 EPA06874.1 - 2.9e-70 236.1 11.2 2.9e-70 236.1 11.2 2.1 1 1 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 EPA06874.1 - 7.1e-22 77.1 1.5 7.1e-22 77.1 1.5 3.5 3 2 2 5 5 5 1 C-terminal topoisomerase domain Topoisom_I_N PF02919.15 EPA06874.1 - 4.3e-17 62.3 0.4 4.3e-17 62.3 0.4 3.2 2 1 1 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment MS_channel PF00924.18 EPA06874.1 - 0.12 11.9 4.9 0.1 12.1 1.2 2.3 2 0 0 2 2 2 0 Mechanosensitive ion channel DUF3135 PF11333.8 EPA06874.1 - 0.28 11.4 3.1 0.47 10.7 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3135) PhoU PF01895.19 EPA06874.1 - 2.7 8.5 8.0 2.8 8.5 0.1 3.4 3 1 1 4 4 4 0 PhoU domain Filament PF00038.21 EPA06876.1 - 0.0087 15.7 1.0 0.0093 15.6 1.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Archaea/Thaumarchaeota/Candidatus_Nitrosoarchaeum_limnia_BG20-ASM24114v2/GCA_000241145.2_ASM24114v2_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Archaea/Thaumarchaeota/Candidatus_Nitrosoarchaeum_limnia_BG20-ASM24114v2/GCA_000241145.2_ASM24114v2_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Archaea/Thaumarchaeota/Candidatus_Nitrosoarchaeum_limnia_BG20-ASM24114v2/GCA_000241145.2_ASM24114v2_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Archaea/Thaumarchaeota/Candidatus_Nitrosoarchaeum_limnia_BG20-ASM24114v2/GCA_000241145.2_ASM24114v2_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 16:23:40 2019 # [ok]