# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- HA2 PF04408.23 CDI73657.1 - 3.4e-19 69.1 0.0 3.4e-19 69.1 0.0 3.4 2 1 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDI73657.1 - 8.2e-17 61.3 0.0 1.6e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDI73657.1 - 8.9e-13 48.6 0.0 2.2e-12 47.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDI73657.1 - 0.00027 20.8 0.0 0.00071 19.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 CDI73657.1 - 0.0015 18.8 0.7 0.0051 17.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CDI73657.1 - 0.0024 17.0 1.8 0.0054 15.8 1.8 1.5 1 1 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 CDI73657.1 - 0.0029 17.9 0.1 0.0029 17.9 0.1 3.6 3 2 1 4 4 4 1 AAA domain cobW PF02492.19 CDI73657.1 - 0.07 12.7 0.1 1.7 8.2 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 CDI73657.1 - 0.15 12.4 0.1 0.15 12.4 0.1 4.3 1 1 1 2 2 1 0 AAA ATPase domain ABC_tran PF00005.27 CDI73657.1 - 2 9.0 3.8 2.6 8.6 0.0 2.9 2 1 0 2 2 2 0 ABC transporter AAA_23 PF13476.6 CDI73657.1 - 3.8 8.0 0.0 3.8 8.0 0.0 3.3 2 1 0 2 2 1 0 AAA domain Serpin PF00079.20 CDI73658.1 - 3.2e-77 260.4 0.0 3.7e-77 260.1 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) CHD5 PF04420.14 CDI73659.1 - 5.8e-07 29.5 2.0 8.5e-07 29.0 2.0 1.3 1 0 0 1 1 1 1 CHD5-like protein Enterotoxin_HS1 PF08090.11 CDI73659.1 - 0.2 11.6 0.3 0.2 11.6 0.3 2.0 2 0 0 2 2 2 0 Heat stable E.coli enterotoxin 1 CENP-H PF05837.12 CDI73659.1 - 0.67 10.4 9.8 0.99 9.8 9.8 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) dsDNA_bind PF01984.20 CDI73660.1 - 7.7e-21 74.5 11.5 9.6e-21 74.1 11.5 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Lipase_chap PF03280.14 CDI73660.1 - 0.0026 17.8 7.1 0.0033 17.4 7.1 1.3 1 0 0 1 1 1 1 Proteobacterial lipase chaperone protein DUF4953 PF16313.5 CDI73660.1 - 0.076 12.2 1.4 0.096 11.9 1.4 1.1 1 0 0 1 1 1 0 Met-zincin RRP14 PF15459.6 CDI73660.1 - 0.19 12.4 4.6 4.5 8.0 3.6 2.3 2 1 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 DUF1682 PF07946.14 CDI73660.1 - 0.36 10.0 4.8 0.44 9.7 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF3886 PF13025.6 CDI73660.1 - 1.2 9.4 12.9 1.2 9.4 11.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3886) Serpin PF00079.20 CDI73661.1 - 1.2e-76 258.4 0.0 1.5e-76 258.2 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Cpn60_TCP1 PF00118.24 CDI73662.1 - 4.1e-90 302.8 16.9 8.7e-90 301.7 16.9 1.5 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Fis1_TPR_C PF14853.6 CDI73663.1 - 5.1e-16 58.5 0.2 9.5e-16 57.6 0.2 1.5 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 CDI73663.1 - 6e-06 25.8 0.0 1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 CDI73663.1 - 0.00043 20.2 0.3 0.0019 18.1 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDI73663.1 - 0.0053 17.4 0.2 0.028 15.0 0.5 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDI73663.1 - 0.029 14.9 0.1 0.054 14.0 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDI73663.1 - 0.045 14.0 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDI73663.1 - 0.082 13.8 0.5 1.2 10.2 0.1 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDI73663.1 - 0.088 13.5 0.5 0.28 11.9 0.1 2.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3223 PF11523.8 CDI73664.1 - 0.055 14.3 0.0 0.079 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3223) NPH3 PF03000.14 CDI73665.1 - 0.01 15.5 1.9 0.049 13.3 1.9 2.2 1 0 0 1 1 1 0 NPH3 family DNA_pol_E_B PF04042.16 CDI73666.1 - 1.8e-19 70.0 1.3 1.8e-19 70.0 1.3 2.2 3 0 0 3 3 3 1 DNA polymerase alpha/epsilon subunit B DUF2722 PF10846.8 CDI73666.1 - 0.0012 17.9 1.3 0.0022 17.0 1.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI73666.1 - 0.12 12.5 19.0 5.4 7.1 0.0 3.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 CCDC53 PF10152.9 CDI73666.1 - 2.9 8.3 9.5 0.93 9.9 3.6 2.6 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Ribosomal_60s PF00428.19 CDI73666.1 - 7.5 7.2 21.8 7.2 7.3 5.6 3.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein C2 PF00168.30 CDI73667.1 - 5.2e-37 126.3 0.0 7.8e-10 39.0 0.0 6.9 7 0 0 7 7 7 6 C2 domain Ferlin_C PF16165.5 CDI73667.1 - 0.067 13.1 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 Ferlin C-terminus FerI PF08151.12 CDI73667.1 - 0.16 12.1 0.0 0.79 9.9 0.0 2.0 2 0 0 2 2 2 0 FerI (NUC094) domain zf-RING_2 PF13639.6 CDI73668.1 - 1.9e-11 44.1 9.8 2.9e-11 43.5 9.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CDI73668.1 - 9e-10 38.1 7.0 2e-09 37.0 7.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 CDI73668.1 - 1.9e-06 27.6 9.1 2.9e-06 27.1 9.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CDI73668.1 - 5.4e-06 26.4 1.7 9.7e-06 25.6 1.7 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 CDI73668.1 - 1.3e-05 24.9 8.9 2.2e-05 24.2 8.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDI73668.1 - 1.4e-05 25.3 9.8 3.4e-05 24.0 9.8 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 CDI73668.1 - 0.00022 21.0 5.1 0.00032 20.5 5.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDI73668.1 - 0.00024 21.0 7.3 0.00054 19.9 7.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDI73668.1 - 0.00032 20.6 7.6 0.00049 20.0 7.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 CDI73668.1 - 0.00057 19.5 6.0 0.00091 18.8 6.0 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-Nse PF11789.8 CDI73668.1 - 0.0017 18.1 3.7 0.0031 17.3 3.7 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.7 CDI73668.1 - 0.049 13.8 7.9 0.097 12.8 7.9 1.5 1 0 0 1 1 1 0 RING-variant domain Prok-RING_4 PF14447.6 CDI73668.1 - 0.1 12.4 7.7 0.17 11.8 7.7 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CDI73668.1 - 0.26 11.5 8.2 0.49 10.6 8.2 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 CDI73668.1 - 0.36 11.2 5.7 0.62 10.4 5.7 1.4 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 CDI73668.1 - 0.68 10.2 8.5 3.3 8.0 8.5 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain Pox_A_type_inc PF04508.12 CDI73669.1 - 1.3 9.0 4.9 3.6 7.6 0.2 3.3 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat FapA PF03961.13 CDI73669.1 - 5.5 5.5 25.1 0.032 12.8 3.3 2.6 1 1 1 2 2 2 0 Flagellar Assembly Protein A Phosphodiest PF01663.22 CDI73670.1 - 0.0012 18.5 0.0 0.002 17.8 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase cNMP_binding PF00027.29 CDI73672.1 - 1.7e-80 265.1 2.9 7.9e-19 67.5 0.0 6.6 6 0 0 6 6 6 6 Cyclic nucleotide-binding domain EF-hand_6 PF13405.6 CDI73672.1 - 0.0042 16.9 0.5 0.25 11.4 0.1 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 CDI73672.1 - 0.0052 16.2 0.7 0.1 12.2 0.1 2.7 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 CDI73672.1 - 0.1 13.1 0.2 4.3 7.9 0.0 3.7 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_8 PF13833.6 CDI73672.1 - 0.23 11.4 0.7 1.1 9.1 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain pair Shugoshin_N PF07558.11 CDI73672.1 - 5.6 6.9 6.5 54 3.8 0.0 4.0 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region RRM_1 PF00076.22 CDI73673.1 - 2.8e-05 23.9 0.0 0.28 11.1 0.0 3.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 CDI73673.1 - 0.068 13.4 0.0 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter PRP21_like_P PF12230.8 CDI73674.1 - 7.5e-43 146.9 2.1 7.5e-43 146.9 2.1 2.1 2 0 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 CDI73674.1 - 1.3e-37 127.5 1.1 1.7e-17 63.1 0.0 3.6 4 0 0 4 4 4 2 Surp module DUF1682 PF07946.14 CDI73674.1 - 0.0012 18.1 2.7 0.0012 18.1 2.7 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1682) Borrelia_orfA PF02414.15 CDI73674.1 - 0.014 15.1 0.0 0.037 13.7 0.0 1.7 2 0 0 2 2 2 0 Borrelia ORF-A EIF_2_alpha PF07541.12 CDI73674.1 - 0.13 12.4 0.9 0.22 11.6 0.1 1.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit DUF2457 PF10446.9 CDI73675.1 - 0.79 8.8 28.7 1.1 8.3 28.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF2722 PF10846.8 CDI73676.1 - 0.00043 19.4 4.8 0.00043 19.4 4.8 16.9 11 4 2 13 13 13 3 Protein of unknown function (DUF2722) Caldesmon PF02029.15 CDI73676.1 - 0.00065 18.6 21.6 0.00065 18.6 21.6 8.5 8 1 0 8 8 8 1 Caldesmon ASH PF15780.5 CDI73676.1 - 0.00096 19.3 0.2 0.062 13.5 0.0 3.5 3 0 0 3 3 3 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin RskA PF10099.9 CDI73676.1 - 0.0022 18.3 13.0 0.0022 18.3 13.0 24.3 10 6 9 20 20 20 4 Anti-sigma-K factor rskA SDA1 PF05285.12 CDI73676.1 - 0.0028 17.1 12.5 0.0028 17.1 12.5 8.6 10 1 0 10 10 10 1 SDA1 PapD-like PF14874.6 CDI73676.1 - 0.0054 16.9 4.3 1.2 9.3 0.1 4.4 5 0 0 5 5 5 1 Flagellar-associated PapD-like HipN PF18253.1 CDI73677.1 - 5.8e-16 57.9 0.0 1.1e-15 57.0 0.0 1.5 1 0 0 1 1 1 1 Hsp70-interacting protein N N-terminal domain STI1 PF17830.1 CDI73677.1 - 9e-05 22.3 0.2 0.00019 21.3 0.2 1.5 1 0 0 1 1 1 1 STI1 domain PMSR PF01625.21 CDI73677.1 - 0.031 14.5 0.7 0.05 13.8 0.7 1.3 1 0 0 1 1 1 0 Peptide methionine sulfoxide reductase Rrn6 PF10214.9 CDI73677.1 - 0.54 8.7 2.4 0.71 8.3 2.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor KCT2 PF17818.1 CDI73677.1 - 1.5 9.0 4.3 2.2 8.4 4.3 1.2 1 0 0 1 1 1 0 Keratinocyte-associated gene product CBP4 PF07960.11 CDI73677.1 - 2.8 7.8 11.9 4.7 7.1 11.9 1.3 1 0 0 1 1 1 0 CBP4 DUF3402 PF11882.8 CDI73677.1 - 5.3 6.0 9.5 10 5.1 9.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3402) FKBP_N PF01346.18 CDI73677.1 - 5.3 8.1 10.6 2.2e+02 2.9 9.1 3.0 3 0 0 3 3 3 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase TMA7 PF09072.10 CDI73677.1 - 8.1 7.4 13.9 6.2 7.7 4.4 2.7 2 0 0 2 2 2 0 Translation machinery associated TMA7 SARAF PF06682.12 CDI73678.1 - 0.00039 20.2 5.6 0.00039 20.2 5.6 1.9 2 0 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis Arm PF00514.23 CDI73678.1 - 0.0011 19.0 3.8 0.86 9.7 0.1 4.3 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat RskA PF10099.9 CDI73678.1 - 0.0048 17.2 21.8 0.0048 17.2 21.8 4.5 2 2 1 3 3 1 1 Anti-sigma-K factor rskA MDM31_MDM32 PF08118.11 CDI73678.1 - 0.0062 15.3 4.2 0.0062 15.3 4.2 1.5 2 0 0 2 2 2 1 Yeast mitochondrial distribution and morphology (MDM) proteins MecA PF05389.12 CDI73678.1 - 0.1 12.2 5.5 0.13 11.8 2.8 2.1 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) AAA_23 PF13476.6 CDI73678.1 - 0.21 12.1 18.0 0.26 11.8 5.7 2.2 2 0 0 2 2 2 0 AAA domain Sporozoite_P67 PF05642.11 CDI73678.1 - 0.27 9.3 2.3 2.5 6.0 0.8 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen PRR18 PF15671.5 CDI73678.1 - 0.74 9.6 16.5 1.6 8.6 0.7 2.2 2 0 0 2 2 2 0 Proline-rich protein family 18 EOS1 PF12326.8 CDI73678.1 - 0.82 9.6 2.9 0.75 9.7 1.1 1.8 2 0 0 2 2 2 0 N-glycosylation protein Band_3_cyto PF07565.13 CDI73678.1 - 0.98 9.2 15.1 0.58 9.9 8.7 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Membralin PF09746.9 CDI73678.1 - 1.3 8.0 7.0 0.28 10.2 2.9 1.7 2 0 0 2 2 2 0 Tumour-associated protein MAT1 PF06391.13 CDI73678.1 - 1.5 8.6 23.7 0.5 10.2 14.2 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 CemA PF03040.14 CDI73678.1 - 2.3 8.1 10.6 3.5 7.5 4.8 2.2 2 0 0 2 2 2 0 CemA family eIF-3_zeta PF05091.12 CDI73678.1 - 3.1 6.7 16.8 0.15 11.0 8.1 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI73678.1 - 3.7 6.2 18.4 0.98 8.1 11.3 2.1 2 0 0 2 2 2 0 Presenilin V_ATPase_I PF01496.19 CDI73678.1 - 3.9 5.3 17.7 1.2 7.0 10.9 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family NopRA1 PF16201.5 CDI73678.1 - 6.5 6.3 9.3 0.37 10.3 2.0 2.5 2 1 0 2 2 2 0 Nucleolar pre-ribosomal-associated protein 1 Connexin PF00029.19 CDI73678.1 - 7.4 6.3 8.2 0.37 10.5 2.0 1.9 2 0 0 2 2 2 0 Connexin GET2 PF08690.10 CDI73678.1 - 7.8 6.1 26.1 0.044 13.5 13.0 2.2 2 0 0 2 2 2 0 GET complex subunit GET2 DUF1644 PF07800.12 CDI73679.1 - 0.017 15.2 1.6 0.017 15.2 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) XRN_M PF17846.1 CDI73679.1 - 0.02 13.8 10.9 0.024 13.6 10.9 1.0 1 0 0 1 1 1 0 Xrn1 helical domain SLC12 PF03522.15 CDI73679.1 - 0.026 13.6 14.7 0.032 13.3 14.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PRP1_N PF06424.12 CDI73679.1 - 0.039 14.3 13.8 1.2 9.5 0.2 2.1 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Presenilin PF01080.17 CDI73679.1 - 0.053 12.3 16.4 0.068 11.9 16.4 1.1 1 0 0 1 1 1 0 Presenilin DUF2828 PF11443.8 CDI73679.1 - 0.24 9.5 10.8 0.33 9.0 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) ATAD4 PF15321.6 CDI73679.1 - 0.48 11.8 10.0 1.3 10.4 2.2 2.2 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 RNase_H2_suC PF08615.11 CDI73679.1 - 0.51 10.5 12.9 2.3 8.4 0.5 2.1 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) RPA43_OB PF17875.1 CDI73679.1 - 0.64 10.6 10.9 1.9 9.1 2.6 2.1 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I EST1 PF10374.9 CDI73679.1 - 0.69 10.5 18.1 1 10.0 18.1 1.2 1 0 0 1 1 1 0 Telomerase activating protein Est1 DUF3391 PF11871.8 CDI73679.1 - 0.71 10.4 18.5 1.3 9.5 8.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) G0-G1_switch_2 PF15103.6 CDI73679.1 - 0.75 10.3 14.4 1.7 9.1 1.6 2.3 2 0 0 2 2 2 0 G0/G1 switch protein 2 YABBY PF04690.13 CDI73679.1 - 0.93 10.0 11.8 0.63 10.6 3.8 2.1 2 0 0 2 2 2 0 YABBY protein TFB6 PF17110.5 CDI73679.1 - 1 9.1 11.9 1 9.1 3.5 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF1840 PF08895.11 CDI73679.1 - 1.1 9.6 21.0 2.2 8.6 11.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Peptidase_S49_N PF08496.10 CDI73679.1 - 1.3 9.1 17.1 4.4 7.3 1.1 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF3086 PF11285.8 CDI73679.1 - 1.7 7.7 21.4 0.27 10.3 12.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3086) Otopetrin PF03189.13 CDI73679.1 - 1.7 7.4 8.6 2.3 6.9 8.6 1.1 1 0 0 1 1 1 0 Otopetrin Orf78 PF06024.12 CDI73679.1 - 1.7 9.0 11.0 6.9 7.0 0.2 2.2 2 0 0 2 2 2 0 Orf78 (ac78) AIF_C PF14721.6 CDI73679.1 - 2.3 8.6 14.7 6.3 7.2 6.0 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Exonuc_VII_L PF02601.15 CDI73679.1 - 3 7.3 22.0 3.8 7.0 22.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit eIF_4EBP PF05456.11 CDI73679.1 - 3.6 7.6 16.3 3.2 7.7 1.7 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) DUF4407 PF14362.6 CDI73679.1 - 4.6 6.5 26.4 6.6 6.0 26.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF775 PF05603.12 CDI73679.1 - 5.4 6.5 24.4 0.81 9.2 10.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF775) Sec62 PF03839.16 CDI73679.1 - 6.1 6.3 16.5 2.5 7.5 8.0 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 Hid1 PF12722.7 CDI73679.1 - 8.8 4.3 16.1 12 3.8 16.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CobT PF06213.12 CDI73679.1 - 9.4 5.5 31.7 3.1 7.1 14.3 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Muted PF14942.6 CDI73679.1 - 9.7 6.5 29.3 1.6 9.1 16.4 2.1 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein HC2 PF07382.11 CDI73680.1 - 2.3e-14 53.9 177.0 1.1e-09 38.7 85.5 3.4 1 1 3 4 4 4 3 Histone H1-like nucleoprotein HC2 TPR_8 PF13181.6 CDI73681.1 - 6.5e-11 41.6 5.6 4.2e-05 23.4 0.1 5.7 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDI73681.1 - 7e-10 38.3 6.6 8e-05 22.5 0.1 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDI73681.1 - 2e-09 36.8 4.8 0.00032 20.4 0.0 6.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI73681.1 - 5.8e-09 36.0 13.4 0.004 17.9 0.1 6.4 4 2 3 7 7 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 CDI73681.1 - 2.5e-07 30.6 0.7 0.049 14.0 0.0 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDI73681.1 - 2.7e-07 30.2 1.2 0.22 11.3 0.1 5.0 6 0 0 6 6 6 2 TPR repeat TPR_19 PF14559.6 CDI73681.1 - 4e-06 27.2 1.0 8.8e-05 22.9 0.1 5.9 4 2 2 6 6 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDI73681.1 - 3.4e-05 23.9 0.3 1.3 9.2 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDI73681.1 - 4.4e-05 23.2 5.9 2.5 8.4 0.0 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDI73681.1 - 0.00025 21.3 11.0 0.055 13.8 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat Dehydrin PF00257.19 CDI73681.1 - 0.012 16.2 12.3 0.013 16.0 7.6 2.3 2 0 0 2 2 2 0 Dehydrin TPR_6 PF13174.6 CDI73681.1 - 0.028 15.1 4.0 0.44 11.3 0.0 4.3 4 1 0 4 4 4 0 Tetratricopeptide repeat PPR PF01535.20 CDI73681.1 - 0.089 13.1 2.5 16 6.0 0.1 3.8 3 0 0 3 3 3 0 PPR repeat RskA PF10099.9 CDI73681.1 - 1.8 8.8 9.2 1.9 8.8 2.8 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA TPR_16 PF13432.6 CDI73681.1 - 3.3 8.4 16.3 3.6 8.3 0.0 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat Spt20 PF12090.8 CDI73682.1 - 0.00018 21.2 14.0 0.00018 21.2 14.0 4.8 3 2 1 4 4 4 1 Spt20 family SR-25 PF10500.9 CDI73682.1 - 0.00035 20.3 6.7 0.00035 20.3 6.7 4.6 4 2 0 4 4 4 1 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 CDI73682.1 - 0.0014 16.9 9.4 0.0014 16.9 9.4 2.7 2 1 0 2 2 2 1 AF-4 proto-oncoprotein DUF1635 PF07795.11 CDI73682.1 - 0.0086 16.0 6.2 0.0086 16.0 6.2 3.6 3 1 0 3 3 3 1 Protein of unknown function (DUF1635) Cellulose_synt PF03552.14 CDI73682.1 - 0.46 8.9 1.9 0.73 8.3 1.9 1.3 1 0 0 1 1 1 0 Cellulose synthase 7TM_GPCR_Sru PF10322.9 CDI73682.1 - 0.57 9.4 0.8 0.92 8.8 0.8 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sru s48_45 PF07422.13 CDI73683.1 - 0.015 15.9 0.4 0.019 15.5 0.4 1.3 1 0 0 1 1 1 0 Sexual stage antigen s48/45 domain AAA_6 PF12774.7 CDI73683.1 - 0.015 14.3 8.6 0.02 13.9 8.6 1.1 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region eIF3_subunit PF08597.10 CDI73683.1 - 0.017 15.0 10.4 0.017 15.0 10.4 2.1 1 1 1 2 2 2 0 Translation initiation factor eIF3 subunit SUIM_assoc PF16619.5 CDI73683.1 - 0.25 11.5 0.0 0.25 11.5 0.0 3.7 2 1 1 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI73683.1 - 2.9 7.8 28.2 4 7.3 28.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 CDI73683.1 - 4.3 6.3 16.5 4.9 6.1 16.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Zn_ribbon_17 PF17120.5 CDI73684.1 - 0.073 12.7 1.0 0.49 10.1 0.1 2.3 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Galactosyl_T PF01762.21 CDI73685.1 - 2.8e-47 161.1 0.0 3.6e-47 160.7 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 CDI73685.1 - 0.034 13.6 0.0 0.054 12.9 0.0 1.3 1 0 0 1 1 1 0 Fringe-like Galactosyl_T PF01762.21 CDI73686.1 - 2e-43 148.5 0.0 2.4e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 CDI73686.1 - 0.0018 17.7 0.0 0.0024 17.4 0.0 1.1 1 0 0 1 1 1 1 Fringe-like DEAD PF00270.29 CDI73690.1 - 1.5e-43 148.6 0.0 5.9e-43 146.7 0.0 2.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI73690.1 - 1.7e-30 105.6 0.0 9.5e-30 103.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI73690.1 - 2.8e-06 27.5 0.0 1.7e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 CDI73690.1 - 0.00091 18.6 0.1 0.002 17.5 0.1 1.5 1 0 0 1 1 1 1 SecA DEAD-like domain zf-CCHC PF00098.23 CDI73690.1 - 4.7 7.5 8.6 0.36 11.0 3.6 1.8 2 0 0 2 2 2 0 Zinc knuckle AAA PF00004.29 CDI73691.1 - 3.6e-29 101.9 0.0 6.4e-29 101.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDI73691.1 - 1.6e-05 25.2 0.2 0.0029 17.9 0.0 2.6 2 1 1 3 3 2 1 AAA domain AAA_16 PF13191.6 CDI73691.1 - 0.00086 19.7 0.3 0.0028 18.0 0.3 1.7 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 CDI73691.1 - 0.0013 18.5 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CDI73691.1 - 0.0033 16.8 0.2 0.0064 15.9 0.2 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDI73691.1 - 0.0038 17.2 0.0 0.012 15.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 CDI73691.1 - 0.011 15.5 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 CDI73691.1 - 0.019 14.6 0.4 0.24 10.9 0.1 2.4 2 1 0 3 3 3 0 AAA domain NACHT PF05729.12 CDI73691.1 - 0.05 13.5 0.1 1 9.3 0.0 2.5 2 1 1 3 3 3 0 NACHT domain AAA_28 PF13521.6 CDI73691.1 - 0.058 13.6 0.1 0.14 12.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.14 CDI73691.1 - 0.067 13.3 0.0 0.32 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CDI73691.1 - 0.072 13.2 0.2 0.18 11.9 0.1 1.8 2 1 0 2 2 2 0 AAA domain TIP49 PF06068.13 CDI73691.1 - 0.087 12.0 0.0 0.51 9.5 0.0 1.9 1 1 1 2 2 2 0 TIP49 P-loop domain AFG1_ATPase PF03969.16 CDI73691.1 - 0.09 11.6 0.1 0.36 9.7 0.1 1.8 1 1 1 2 2 2 0 AFG1-like ATPase AAA_24 PF13479.6 CDI73691.1 - 0.12 12.1 0.4 0.26 11.0 0.1 1.8 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CDI73691.1 - 0.13 12.7 0.0 0.88 10.0 0.0 2.3 3 0 0 3 3 2 0 RNA helicase AAA_18 PF13238.6 CDI73691.1 - 0.14 12.7 0.0 0.25 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 CDI73691.1 - 0.16 11.0 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 CDI73691.1 - 0.16 11.5 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region BTB PF00651.31 CDI73692.1 - 1.4e-15 57.4 0.0 9.1e-15 54.9 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain CFAP91 PF14738.6 CDI73694.1 - 3.6e-26 92.0 1.9 3.6e-26 92.0 1.9 2.6 2 1 0 2 2 2 1 Cilia- and flagella-associated protein 91 DHO_dh PF01180.21 CDI73694.1 - 0.2 10.8 0.1 0.34 10.1 0.1 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase SRC-1 PF08832.10 CDI73696.1 - 0.026 15.6 3.4 0.6 11.2 0.0 2.2 2 0 0 2 2 2 0 Steroid receptor coactivator DUF755 PF05501.11 CDI73696.1 - 0.029 14.6 9.1 0.061 13.6 9.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF755) SPX PF03105.19 CDI73696.1 - 0.069 13.1 2.1 0.084 12.8 2.1 1.1 1 0 0 1 1 1 0 SPX domain DUF3446 PF11928.8 CDI73696.1 - 1.6 9.1 14.3 1.5 9.2 8.2 2.2 2 0 0 2 2 2 0 Early growth response N-terminal domain SR-25 PF10500.9 CDI73696.1 - 7.2 6.2 18.6 10 5.6 18.6 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Glycos_transf_1 PF00534.20 CDI73699.1 - 0.0006 19.4 0.0 0.011 15.3 0.0 3.0 2 1 1 3 3 3 1 Glycosyl transferases group 1 Presenilin PF01080.17 CDI73699.1 - 0.0045 15.8 13.5 0.0045 15.8 13.5 5.3 4 1 1 5 5 5 3 Presenilin DUF3464 PF11947.8 CDI73700.1 - 0.0026 17.5 12.0 0.0026 17.5 12.0 2.8 3 0 0 3 3 3 1 Photosynthesis affected mutant 68 Spt20 PF12090.8 CDI73700.1 - 0.12 11.9 76.7 0.019 14.6 45.3 2.8 3 0 0 3 3 3 0 Spt20 family CNDH2_C PF16858.5 CDI73700.1 - 0.19 11.6 22.2 0.32 10.8 22.2 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CDC45 PF02724.14 CDI73700.1 - 0.61 8.3 17.8 0.91 7.7 17.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 CDI73700.1 - 0.86 9.9 24.1 2.2 8.6 24.1 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PA26 PF04636.13 CDI73700.1 - 1.5 7.6 16.9 2.7 6.8 16.9 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF572 PF04502.13 CDI73700.1 - 2.7 7.5 24.2 0.24 11.0 18.8 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF572) V_ATPase_I PF01496.19 CDI73700.1 - 3.2 5.6 23.4 5 4.9 23.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ALMT PF11744.8 CDI73700.1 - 5 5.9 17.6 9.5 4.9 17.6 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 CDI73700.1 - 6.5 5.7 26.5 10 5.0 26.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Peptidase_C48 PF02902.19 CDI73701.1 - 0.015 15.1 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Ulp1 protease family, C-terminal catalytic domain SR-25 PF10500.9 CDI73701.1 - 0.02 14.5 12.3 0.032 13.8 12.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Menin PF05053.13 CDI73701.1 - 0.036 12.4 4.0 0.046 12.1 4.0 1.2 1 0 0 1 1 1 0 Menin IMUP PF15761.5 CDI73701.1 - 0.05 14.3 8.9 0.1 13.3 8.9 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein JUPITER PF17054.5 CDI73701.1 - 0.08 12.4 8.2 0.12 11.9 8.2 1.2 1 0 0 1 1 1 0 Microtubule-Associated protein Jupiter Dehydrin PF00257.19 CDI73701.1 - 0.09 13.3 6.5 0.15 12.6 6.5 1.4 1 0 0 1 1 1 0 Dehydrin Secretin_N_2 PF07655.13 CDI73701.1 - 0.94 10.1 14.9 1.4 9.5 14.9 1.2 1 0 0 1 1 1 0 Secretin N-terminal domain BAF1_ABF1 PF04684.13 CDI73701.1 - 2.5 7.0 7.0 3.5 6.6 7.0 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor AF-4 PF05110.13 CDI73701.1 - 4.6 5.2 11.3 5.8 4.9 11.3 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Syntaphilin PF15290.6 CDI73701.1 - 8.8 5.9 8.3 16 5.0 8.3 1.4 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp Hamartin PF04388.12 CDI73702.1 - 0.042 12.5 29.2 0.044 12.4 29.2 1.0 1 0 0 1 1 1 0 Hamartin protein SLC12 PF03522.15 CDI73702.1 - 0.28 10.1 30.2 0.29 10.1 30.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 CDI73702.1 - 0.43 9.3 36.9 0.51 9.0 36.9 1.2 1 0 0 1 1 1 0 Presenilin LAP1C PF05609.12 CDI73702.1 - 0.74 8.8 29.5 0.78 8.8 29.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) HI0933_like PF03486.14 CDI73702.1 - 0.91 8.2 17.5 1.1 7.8 17.5 1.1 1 0 0 1 1 1 0 HI0933-like protein NPR3 PF03666.13 CDI73702.1 - 1.1 8.0 27.8 1.5 7.5 27.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF966 PF06136.13 CDI73702.1 - 1.6 8.3 24.1 1.8 8.2 24.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) V_ATPase_I PF01496.19 CDI73702.1 - 1.7 6.5 32.0 2.5 5.9 32.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Caldesmon PF02029.15 CDI73702.1 - 2.8 6.6 38.0 3.5 6.3 38.0 1.2 1 0 0 1 1 1 0 Caldesmon PAT1 PF09770.9 CDI73702.1 - 4.8 5.3 54.1 5.4 5.1 54.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Nop53 PF07767.11 CDI73702.1 - 8.5 5.6 43.6 14 5.0 43.6 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RSB_motif PF16294.5 CDI73703.1 - 0.022 15.0 0.3 0.022 15.0 0.3 3.0 3 0 0 3 3 3 0 RNSP1-SAP18 binding (RSB) motif Spt20 PF12090.8 CDI73703.1 - 5.6 6.5 60.0 2 8.0 16.7 3.5 3 0 0 3 3 3 0 Spt20 family Pal1 PF08316.11 CDI73703.1 - 8.8 7.1 11.8 1.8 9.3 0.8 3.1 3 0 0 3 3 3 0 Pal1 cell morphology protein EPL1 PF10513.9 CDI73703.1 - 9.5 6.6 22.5 8.6 6.7 5.0 3.2 3 0 0 3 3 3 0 Enhancer of polycomb-like WD40 PF00400.32 CDI73704.1 - 1.2e-05 26.0 0.0 0.087 13.7 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat Androgen_recep PF02166.16 CDI73704.1 - 0.0011 17.9 4.5 0.0011 17.9 4.5 2.8 2 1 0 2 2 2 1 Androgen receptor NST1 PF13945.6 CDI73704.1 - 0.0024 18.0 4.8 0.0024 18.0 4.8 2.2 2 0 0 2 2 2 1 Salt tolerance down-regulator Nup160 PF11715.8 CDI73704.1 - 0.0049 15.6 0.3 0.0049 15.6 0.3 2.1 1 1 0 2 2 1 1 Nucleoporin Nup120/160 AP3D1 PF06375.11 CDI73704.1 - 0.0069 16.6 16.1 0.02 15.1 3.1 2.3 2 0 0 2 2 2 1 AP-3 complex subunit delta-1 ANAPC_CDC26 PF10471.9 CDI73704.1 - 0.0089 16.8 9.5 0.0089 16.8 9.5 3.3 2 1 1 3 3 3 1 Anaphase-promoting complex APC subunit CDC26 DUF2722 PF10846.8 CDI73704.1 - 0.01 14.9 25.7 0.015 14.2 11.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF1635 PF07795.11 CDI73704.1 - 0.019 14.8 18.3 0.32 10.8 3.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Coilin_N PF15862.5 CDI73704.1 - 0.03 14.1 22.6 0.55 10.0 8.6 2.3 2 0 0 2 2 2 0 Coilin N-terminus SR-25 PF10500.9 CDI73704.1 - 0.031 13.9 35.1 0.15 11.7 23.9 2.5 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 CDI73704.1 - 0.031 12.9 16.7 0.039 12.5 16.7 1.2 1 0 0 1 1 1 0 Macoilin family DUF702 PF05142.12 CDI73704.1 - 0.041 14.4 11.3 0.22 12.0 3.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF702) ANAPC4_WD40 PF12894.7 CDI73704.1 - 0.046 14.0 0.1 0.19 12.1 0.1 2.1 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 4 WD40 domain DUF3807 PF12720.7 CDI73704.1 - 0.068 13.4 20.5 0.22 11.8 5.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Spt20 PF12090.8 CDI73704.1 - 0.14 11.7 33.1 0.027 14.1 17.7 2.2 2 0 0 2 2 2 0 Spt20 family AIF_C PF14721.6 CDI73704.1 - 0.17 12.3 12.1 1.7 9.0 3.0 2.5 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term BRF1 PF07741.13 CDI73704.1 - 0.17 12.3 10.9 0.24 11.8 3.7 2.6 2 0 0 2 2 2 0 Brf1-like TBP-binding domain rRNA_processing PF08524.11 CDI73704.1 - 0.24 11.4 21.1 0.026 14.6 5.4 2.2 2 0 0 2 2 2 0 rRNA processing TERB2 PF15101.6 CDI73704.1 - 0.35 10.9 18.5 0.036 14.1 4.7 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 PPL5 PF18168.1 CDI73704.1 - 0.39 10.0 13.9 0.39 10.0 1.6 2.2 2 0 0 2 2 2 0 Prim-pol family 5 DUF1764 PF08576.10 CDI73704.1 - 0.51 11.3 17.2 1.6 9.6 4.6 2.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) TCP PF03634.13 CDI73704.1 - 0.62 10.6 20.8 0.69 10.5 3.2 2.3 2 0 0 2 2 2 0 TCP family transcription factor MecA PF05389.12 CDI73704.1 - 0.63 9.6 10.2 1.9 8.1 1.9 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) CNDH2_M PF16869.5 CDI73704.1 - 0.71 10.6 19.9 0.66 10.7 2.1 2.4 2 0 0 2 2 2 0 PF16858 BNIP3 PF06553.12 CDI73704.1 - 0.74 9.5 16.7 0.042 13.5 9.7 2.0 2 0 0 2 2 2 0 BNIP3 DUF5327 PF17261.2 CDI73704.1 - 0.95 10.2 22.3 0.5 11.1 5.6 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5327) Suf PF05843.14 CDI73704.1 - 0.96 9.4 11.1 0.74 9.7 2.3 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) CFIA_Pcf11 PF11526.8 CDI73704.1 - 0.97 10.0 17.3 1.5 9.3 2.4 2.6 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 DAG_kinase_N PF14513.6 CDI73704.1 - 1.1 9.4 15.9 3.4 7.8 2.1 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Otopetrin PF03189.13 CDI73704.1 - 1.1 8.0 10.9 1.7 7.4 2.2 2.1 2 0 0 2 2 2 0 Otopetrin Med3 PF11593.8 CDI73704.1 - 1.1 8.3 19.2 1.9 7.6 13.2 2.4 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal GEMIN8 PF15348.6 CDI73704.1 - 1.2 9.4 19.6 1.3 9.3 6.9 2.2 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 DUF3446 PF11928.8 CDI73704.1 - 1.3 9.4 16.6 0.56 10.6 11.6 2.6 2 0 0 2 2 2 0 Early growth response N-terminal domain Dsh_C PF12316.8 CDI73704.1 - 2.2 8.7 20.1 0.53 10.6 8.0 2.2 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal FAM60A PF15396.6 CDI73704.1 - 2.6 8.0 15.1 2.5 8.1 1.3 2.3 2 0 0 2 2 2 0 Protein Family FAM60A DUF4834 PF16118.5 CDI73704.1 - 2.9 8.9 20.9 1.7 9.6 7.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF5349 PF17298.2 CDI73704.1 - 3.2 7.4 21.2 2.7 7.7 7.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5349) Bul1_N PF04425.12 CDI73704.1 - 3.4 6.3 15.2 0.36 9.5 5.2 2.1 2 0 0 2 2 2 0 Bul1 N terminus Baculo_PP31 PF05311.11 CDI73704.1 - 3.9 6.9 15.8 4.9 6.6 3.6 2.2 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) YABBY PF04690.13 CDI73704.1 - 4.1 8.0 12.8 7.1 7.2 2.1 2.3 2 0 0 2 2 2 0 YABBY protein NPR3 PF03666.13 CDI73704.1 - 4.2 6.1 17.0 0.89 8.3 6.0 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 CCDC106 PF15794.5 CDI73704.1 - 4.4 6.9 23.1 0.95 9.1 10.6 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 PGA2 PF07543.12 CDI73704.1 - 4.8 7.1 14.8 1.8 8.5 3.9 2.7 2 0 0 2 2 2 0 Protein trafficking PGA2 MPM1 PF17234.2 CDI73704.1 - 5.5 7.2 16.8 3.8 7.7 4.7 2.3 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Bud13 PF09736.9 CDI73704.1 - 6.9 7.1 19.3 2.4 8.6 7.0 2.3 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex CENP-L PF13092.6 CDI73704.1 - 7.4 6.8 9.0 0.43 10.8 2.0 2.1 2 0 0 2 2 2 0 Kinetochore complex Sim4 subunit Fta1 CCDC53 PF10152.9 CDI73704.1 - 9.4 6.6 15.8 4.5 7.7 2.5 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex MAP17 PF15807.5 CDI73704.1 - 9.7 6.4 15.5 10 6.3 2.3 2.5 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 CLN3 PF02487.17 CDI73706.1 - 0.0031 16.6 9.0 0.0031 16.6 9.0 1.8 1 1 1 2 2 2 1 CLN3 protein Connexin PF00029.19 CDI73706.1 - 0.005 16.6 10.1 0.005 16.6 10.1 2.2 2 0 0 2 2 2 2 Connexin NicO PF03824.16 CDI73706.1 - 0.022 14.1 6.4 0.032 13.6 6.4 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein DUF4834 PF16118.5 CDI73706.1 - 0.041 14.8 8.1 0.041 14.8 8.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) AGTRAP PF06396.11 CDI73706.1 - 0.099 12.4 2.4 0.088 12.6 0.5 1.8 2 0 0 2 2 2 0 Angiotensin II, type I receptor-associated protein (AGTRAP) SID-1_RNA_chan PF13965.6 CDI73706.1 - 1.9 6.8 7.0 1.1 7.6 5.2 1.4 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 BAF1_ABF1 PF04684.13 CDI73709.1 - 0.41 9.7 30.1 0.46 9.5 30.1 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor TFIIA PF03153.13 CDI73711.1 - 0.002 18.2 42.7 0.0024 18.0 42.7 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI73711.1 - 0.0028 18.0 5.3 0.0028 18.0 5.3 2.7 2 1 0 2 2 1 1 Anti-sigma-K factor rskA Trp_oprn_chp PF09534.10 CDI73711.1 - 0.0034 17.2 0.1 0.0034 17.2 0.1 2.2 2 0 0 2 2 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Nrap_D5 PF17406.2 CDI73711.1 - 0.0058 16.4 0.2 0.0058 16.4 0.2 1.8 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 YfhO PF09586.10 CDI73711.1 - 0.011 14.1 3.4 0.016 13.4 3.4 1.3 1 0 0 1 1 1 0 Bacterial membrane protein YfhO CD20 PF04103.15 CDI73711.1 - 0.14 12.2 1.9 0.17 12.0 0.0 1.9 2 0 0 2 2 2 0 CD20-like family Dpy19 PF10034.9 CDI73711.1 - 0.29 9.3 1.1 0.4 8.8 1.1 1.3 1 0 0 1 1 1 0 Q-cell neuroblast polarisation Herpes_DNAp_acc PF04929.12 CDI73711.1 - 1.3 8.0 16.5 2 7.3 16.5 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor SLC12 PF03522.15 CDI73711.1 - 1.5 7.8 24.4 2.2 7.2 24.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Peptidase_S49_N PF08496.10 CDI73711.1 - 2.9 7.9 32.3 8.4e+03 -3.3 32.3 2.3 1 1 0 1 1 1 0 Peptidase family S49 N-terminal UPF0524 PF15823.5 CDI73711.1 - 4 6.8 11.5 1.2 8.4 8.7 1.5 1 1 1 2 2 2 0 UPF0524 of C3orf70 7tm_7 PF08395.12 CDI73711.1 - 6.9 5.8 13.3 0.019 14.2 4.0 1.4 2 0 0 2 2 1 0 7tm Chemosensory receptor Coilin_N PF15862.5 CDI73711.1 - 9.1 6.1 32.4 0.87 9.4 10.8 2.6 2 0 0 2 2 2 0 Coilin N-terminus Gpi16 PF04113.14 CDI73713.1 - 2.3 6.5 11.0 2.4 6.5 11.0 1.0 1 0 0 1 1 1 0 Gpi16 subunit, GPI transamidase component Fumerase_C PF05683.12 CDI73713.1 - 2.8 7.2 6.3 3 7.1 6.3 1.0 1 0 0 1 1 1 0 Fumarase C-terminus Apt1 PF10351.9 CDI73714.1 - 0.43 9.4 27.6 0.51 9.1 27.6 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Anticodon_1 PF08264.13 CDI73715.1 - 7.2e-11 42.3 0.1 1.3e-10 41.4 0.1 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Spt20 PF12090.8 CDI73715.1 - 0.007 16.0 2.1 0.0094 15.6 2.1 1.2 1 0 0 1 1 1 1 Spt20 family SUIM_assoc PF16619.5 CDI73715.1 - 0.17 11.9 9.9 0.46 10.6 9.9 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF2849 PF11011.8 CDI73715.1 - 3.2 8.5 8.1 0.37 11.5 2.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2849) Exo5 PF09810.9 CDI73716.1 - 0.095 12.2 0.6 0.15 11.5 0.6 1.4 1 0 0 1 1 1 0 Exonuclease V - a 5' deoxyribonuclease DUF3246 PF11596.8 CDI73716.1 - 0.12 11.8 0.2 0.12 11.8 0.2 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3246) XK-related PF09815.9 CDI73716.1 - 0.38 9.8 1.2 0.67 8.9 1.2 1.3 1 0 0 1 1 1 0 XK-related protein Activator_LAG-3 PF11498.8 CDI73717.1 - 0.00024 20.2 102.7 0.0062 15.6 34.1 3.7 3 0 0 3 3 3 3 Transcriptional activator LAG-3 DUF4207 PF13904.6 CDI73717.1 - 0.0011 18.7 31.4 0.0011 18.7 31.4 5.3 5 1 0 5 5 5 1 Domain of unknown function (DUF4207) DUF1180 PF06679.12 CDI73719.1 - 0.0052 17.2 3.7 0.0061 17.0 3.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) TMEM51 PF15345.6 CDI73719.1 - 0.039 13.8 6.5 0.045 13.6 6.5 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 Baculo_11_kDa PF06143.11 CDI73719.1 - 0.047 13.3 0.5 0.047 13.3 0.5 2.0 1 1 1 2 2 2 0 Baculovirus 11 kDa family MSC PF09402.10 CDI73719.1 - 0.054 12.9 3.4 0.058 12.8 3.4 1.0 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain LRRC37AB_C PF14914.6 CDI73719.1 - 0.091 12.7 6.8 0.1 12.5 6.8 1.0 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Peroxin-13_N PF04088.13 CDI73719.1 - 0.1 12.9 2.7 0.11 12.7 2.7 1.0 1 0 0 1 1 1 0 Peroxin 13, N-terminal region OATP PF03137.20 CDI73719.1 - 0.1 10.8 2.1 0.11 10.7 2.1 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CobT PF06213.12 CDI73719.1 - 0.11 11.9 7.0 0.11 11.9 7.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Ctr PF04145.15 CDI73719.1 - 0.16 12.5 1.6 0.17 12.5 1.6 1.0 1 0 0 1 1 1 0 Ctr copper transporter family Mem_trans PF03547.18 CDI73719.1 - 0.35 9.2 1.8 0.36 9.2 1.8 1.0 1 0 0 1 1 1 0 Membrane transport protein Connexin PF00029.19 CDI73719.1 - 0.39 10.5 3.0 0.43 10.3 3.0 1.1 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 CDI73719.1 - 0.49 8.2 6.8 0.54 8.1 6.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pex14_N PF04695.13 CDI73719.1 - 0.51 11.0 12.2 0.53 10.9 12.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CLN3 PF02487.17 CDI73719.1 - 0.64 9.0 3.3 0.67 8.9 3.3 1.0 1 0 0 1 1 1 0 CLN3 protein ABC2_membrane_2 PF12679.7 CDI73719.1 - 0.79 9.0 3.5 0.87 8.8 3.5 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein EphA2_TM PF14575.6 CDI73719.1 - 0.88 10.5 8.9 2.6 9.0 8.9 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain UPF0560 PF10577.9 CDI73719.1 - 0.95 7.9 15.6 0.96 7.9 15.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Conotoxin PF02950.17 CDI73719.1 - 1 10.4 11.8 7.4 7.7 11.8 1.9 1 1 0 1 1 1 0 Conotoxin GRP PF07172.11 CDI73719.1 - 1.1 9.9 6.9 3.7 8.3 6.9 1.7 1 1 0 1 1 1 0 Glycine rich protein family DUF2232 PF09991.9 CDI73719.1 - 1.3 8.1 5.2 1.6 7.8 5.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Neur_chan_memb PF02932.16 CDI73719.1 - 1.6 8.7 5.2 1.8 8.6 5.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM150 PF15129.6 CDI73719.1 - 1.8 8.8 8.5 2.2 8.5 8.5 1.1 1 0 0 1 1 1 0 FAM150 family DUF4175 PF13779.6 CDI73719.1 - 3.9 5.3 19.1 4.1 5.2 19.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SUIM_assoc PF16619.5 CDI73720.1 - 0.0068 16.5 2.0 0.0068 16.5 2.0 5.4 4 1 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 Shadoo PF14999.6 CDI73720.1 - 0.012 15.7 6.0 0.012 15.7 6.0 3.3 1 1 2 3 3 3 0 Shadow of prion protein, neuroprotective Sporozoite_P67 PF05642.11 CDI73720.1 - 0.93 7.5 6.3 1.5 6.8 6.3 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pep1_7 PF17232.2 CDI73721.1 - 1 9.9 6.8 4.7 7.7 0.7 2.9 2 0 0 2 2 2 0 Elicitor peptide 1-7 Nop53 PF07767.11 CDI73722.1 - 0.00058 19.4 17.7 0.00065 19.2 17.7 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Spt5_N PF11942.8 CDI73722.1 - 0.012 16.6 20.1 0.023 15.7 20.1 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal DUF2052 PF09747.9 CDI73722.1 - 0.012 15.7 18.5 0.014 15.6 18.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4175 PF13779.6 CDI73722.1 - 0.022 12.7 28.7 0.021 12.8 28.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) RR_TM4-6 PF06459.12 CDI73722.1 - 0.05 13.4 19.1 0.057 13.2 19.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobT PF06213.12 CDI73722.1 - 0.14 11.5 25.1 0.16 11.4 25.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 CDI73722.1 - 0.18 10.0 16.8 0.21 9.8 16.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Peptidase_U57 PF05582.12 CDI73722.1 - 0.26 10.5 9.6 0.31 10.3 9.6 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Isy1 PF06246.12 CDI73722.1 - 0.27 10.7 17.6 0.31 10.6 17.6 1.1 1 0 0 1 1 1 0 Isy1-like splicing family CLN3 PF02487.17 CDI73722.1 - 0.37 9.8 11.4 0.39 9.7 11.4 1.2 1 0 0 1 1 1 0 CLN3 protein SprA-related PF12118.8 CDI73722.1 - 0.73 8.9 31.3 0.85 8.7 31.3 1.1 1 0 0 1 1 1 0 SprA-related family CCSAP PF15748.5 CDI73722.1 - 1.1 9.4 21.4 1.4 9.1 21.4 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Serinc PF03348.15 CDI73722.1 - 1.4 7.7 12.8 1.7 7.5 12.8 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Radical_SAM_N PF08497.10 CDI73722.1 - 1.6 7.9 6.9 1.6 7.9 6.9 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal Silic_transp PF03842.13 CDI73722.1 - 2.2 6.5 7.5 2.5 6.3 7.5 1.1 1 0 0 1 1 1 0 Silicon transporter Neur_chan_memb PF02932.16 CDI73722.1 - 3 7.8 13.4 3.6 7.6 13.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Bestrophin PF01062.21 CDI73722.1 - 3.9 6.8 6.8 4.7 6.5 6.8 1.0 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel Paramyxo_ncap PF00973.19 CDI73722.1 - 4.6 6.0 11.4 4.9 5.9 11.4 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Zip PF02535.22 CDI73722.1 - 5.4 6.1 14.0 7 5.8 14.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter TCP PF03634.13 CDI73722.1 - 5.4 7.6 20.8 7.4 7.1 20.8 1.3 1 0 0 1 1 1 0 TCP family transcription factor Suf PF05843.14 CDI73722.1 - 6 6.7 22.0 7 6.5 22.0 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) AAA_23 PF13476.6 CDI73722.1 - 7 7.1 25.7 9.4 6.7 25.7 1.1 1 0 0 1 1 1 0 AAA domain SDA1 PF05285.12 CDI73723.1 - 3.7 6.9 14.2 4.2 6.7 14.2 1.0 1 0 0 1 1 1 0 SDA1 Rcd1 PF04078.13 CDI73724.1 - 8.1e-14 51.5 0.1 8.1e-14 51.5 0.1 2.0 2 0 0 2 2 2 1 Cell differentiation family, Rcd1-like Shadoo PF14999.6 CDI73724.1 - 0.0076 16.4 4.2 0.011 15.8 4.2 1.2 1 0 0 1 1 1 1 Shadow of prion protein, neuroprotective SR-25 PF10500.9 CDI73726.1 - 3.7e-05 23.4 34.9 0.00029 20.5 16.1 7.2 4 1 2 6 6 6 3 Nuclear RNA-splicing-associated protein SR-25 PF10500.9 CDI73727.1 - 0.0017 18.0 2.7 0.0017 18.0 2.7 5.5 4 1 0 5 5 5 3 Nuclear RNA-splicing-associated protein CDK2AP PF09806.9 CDI73727.1 - 0.0018 18.4 4.3 0.0018 18.4 4.3 6.2 4 1 0 4 4 4 1 Cyclin-dependent kinase 2-associated protein MFS_Mycoplasma PF07672.13 CDI73727.1 - 0.19 11.0 1.0 0.48 9.7 1.0 1.6 1 0 0 1 1 1 0 Mycoplasma MFS transporter SR-25 PF10500.9 CDI73728.1 - 0.0025 17.5 7.3 0.0025 17.5 7.3 8.5 6 3 3 9 9 9 2 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI73728.1 - 0.0066 16.1 8.0 0.0066 16.1 8.0 8.7 6 2 0 7 7 7 2 Spt20 family Spt20 PF12090.8 CDI73729.1 - 0.59 9.7 18.4 1.5 8.4 18.4 1.6 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 CDI73729.1 - 3.4 6.7 11.0 5.1 6.1 11.0 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Presenilin PF01080.17 CDI73729.1 - 7.8 5.1 6.3 8.9 5.0 6.3 1.2 1 0 0 1 1 1 0 Presenilin SHR-BD PF06650.12 CDI73730.1 - 3.4e-06 26.7 0.0 1.3e-05 24.8 0.0 1.9 2 0 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.11 CDI73730.1 - 7.1e-05 23.1 3.3 9.2e-05 22.7 0.0 3.0 3 0 0 3 3 3 1 Autophagy-related protein C terminal domain SUIM_assoc PF16619.5 CDI73730.1 - 0.0041 17.1 0.3 0.0041 17.1 0.3 11.1 11 3 0 11 11 11 1 Unstructured region C-term to UIM in Ataxin3 VPS13_C PF16909.5 CDI73730.1 - 0.027 14.3 4.7 13 5.5 0.1 3.5 2 1 1 3 3 3 0 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 CDI73731.1 - 2.2e-29 101.9 0.1 2.2e-29 101.9 0.1 2.8 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 CDI73731.1 - 1.8e-09 37.8 2.4 7.8e-06 25.9 0.0 3.7 3 0 0 3 3 3 2 Vacuolar sorting-associated protein 13, N-terminal DUF4667 PF15700.5 CDI73731.1 - 0.0035 17.5 4.3 0.0035 17.5 4.3 3.7 3 1 0 3 3 3 1 Domain of unknown function (DUF4667) Apt1 PF10351.9 CDI73731.1 - 3.4 6.4 16.6 0.036 12.9 5.3 2.9 3 0 0 3 3 3 0 Golgi-body localisation protein domain Abhydrolase_3 PF07859.13 CDI73733.1 - 2.5e-09 37.3 0.0 4.3e-09 36.5 0.0 1.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold COesterase PF00135.28 CDI73733.1 - 9.5e-05 21.5 0.1 0.00013 21.0 0.1 1.1 1 0 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 CDI73733.1 - 0.018 14.5 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 CDI73733.1 - 0.066 12.1 0.0 0.092 11.6 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase ACP_syn_III_C PF08541.10 CDI73734.1 - 3.7e-34 116.7 0.0 1.5e-33 114.8 0.0 1.9 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 CDI73734.1 - 9.4e-24 83.1 0.3 3.1e-23 81.4 0.3 2.0 1 1 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Chal_sti_synt_C PF02797.15 CDI73734.1 - 5e-05 23.3 0.0 8.4e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Pex14_N PF04695.13 CDI73734.1 - 0.0013 19.5 0.1 0.0025 18.5 0.1 1.5 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2722 PF10846.8 CDI73734.1 - 0.0037 16.3 0.1 0.0038 16.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) SAPIS-gp6 PF16722.5 CDI73734.1 - 0.035 14.5 2.0 0.088 13.2 2.0 1.6 1 0 0 1 1 1 0 Pathogenicity island protein gp6 in Staphylococcus Spt20 PF12090.8 CDI73734.1 - 0.048 13.3 8.0 0.082 12.5 8.0 1.3 1 0 0 1 1 1 0 Spt20 family SUIM_assoc PF16619.5 CDI73734.1 - 0.062 13.4 8.9 0.14 12.2 8.9 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Med3 PF11593.8 CDI73734.1 - 0.99 8.5 8.8 1.5 7.9 8.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Cupin_4 PF08007.12 CDI73735.1 - 1.2e-17 64.4 0.0 1.2e-17 64.4 0.0 2.3 2 0 0 2 2 2 1 Cupin superfamily protein Presenilin PF01080.17 CDI73735.1 - 4.1e-05 22.5 20.6 4.1e-05 22.5 20.6 1.7 2 0 0 2 2 2 1 Presenilin Cupin_8 PF13621.6 CDI73735.1 - 0.0011 18.7 0.0 0.0011 18.7 0.0 2.4 1 1 0 2 2 2 1 Cupin-like domain Auxin_canalis PF05703.11 CDI73735.1 - 0.0091 16.0 3.4 0.0091 16.0 3.4 2.1 2 0 0 2 2 2 1 Auxin canalisation Cupin_2 PF07883.11 CDI73735.1 - 0.019 14.6 0.0 0.046 13.4 0.0 1.6 1 0 0 1 1 1 0 Cupin domain Zip PF02535.22 CDI73735.1 - 0.025 13.8 7.4 0.034 13.4 7.4 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter SAGA-Tad1 PF12767.7 CDI73735.1 - 0.91 9.2 24.1 0.39 10.4 20.6 1.9 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit Ribosomal_60s PF00428.19 CDI73735.1 - 3.5 8.3 15.3 0.14 12.7 8.3 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein WD40 PF00400.32 CDI73736.1 - 2.4e-42 142.1 25.9 1.7e-09 38.1 0.1 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI73736.1 - 1.6e-08 34.8 1.5 0.18 12.1 0.0 4.5 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDI73736.1 - 1.7e-05 24.3 0.0 2.7 7.3 0.0 3.6 3 1 1 4 4 4 4 WD40-like domain PQQ_3 PF13570.6 CDI73736.1 - 0.0004 20.8 0.3 0.061 13.8 0.0 3.6 3 1 0 3 3 3 1 PQQ-like domain Nup160 PF11715.8 CDI73736.1 - 0.054 12.1 15.2 0.078 11.6 0.4 4.2 2 1 3 5 5 5 0 Nucleoporin Nup120/160 Adeno_terminal PF02459.15 CDI73736.1 - 0.083 11.3 0.1 0.12 10.8 0.1 1.2 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Citrate_synt PF00285.21 CDI73737.1 - 8.9e-77 258.6 0.0 9.3e-41 140.1 0.0 2.0 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain TFIIA PF03153.13 CDI73738.1 - 0.09 12.8 36.2 0.11 12.5 36.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Mitofilin PF09731.9 CDI73738.1 - 0.16 10.8 32.2 0.19 10.5 32.2 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein BAF1_ABF1 PF04684.13 CDI73738.1 - 0.26 10.3 18.8 0.31 10.1 18.8 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CCSAP PF15748.5 CDI73738.1 - 2.6 8.2 30.4 3.5 7.7 30.4 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated UPF0560 PF10577.9 CDI73738.1 - 3.2 6.2 19.5 3.7 5.9 19.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TPP_enzyme_C PF02775.21 CDI73738.1 - 3.4 7.4 8.0 0.46 10.2 3.5 1.8 1 1 1 2 2 2 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain SRP-alpha_N PF04086.13 CDI73738.1 - 3.6 7.4 36.6 4 7.3 36.6 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF1631 PF07793.11 CDI73738.1 - 6.9 5.0 31.8 8.3 4.7 31.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) SR-25 PF10500.9 CDI73739.1 - 0.00072 19.2 11.0 0.00072 19.2 11.0 6.6 6 0 0 6 6 6 3 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI73739.1 - 0.0052 16.4 5.5 0.0052 16.4 5.5 13.1 6 5 4 10 10 10 1 Spt20 family Auxin_canalis PF05703.11 CDI73740.1 - 0.21 11.5 18.9 0.33 10.8 18.9 1.3 1 0 0 1 1 1 0 Auxin canalisation FAM76 PF16046.5 CDI73740.1 - 2.2 7.6 20.0 2.6 7.3 20.0 1.1 1 0 0 1 1 1 0 FAM76 protein DUF2870 PF11069.8 CDI73740.1 - 2.8 8.4 17.4 2 8.8 10.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) Tub PF01167.18 CDI73741.1 - 0.014 15.2 0.3 0.014 15.2 0.3 1.1 1 0 0 1 1 1 0 Tub family RskA PF10099.9 CDI73741.1 - 0.018 15.4 19.9 0.018 15.4 19.9 2.3 1 1 1 2 2 2 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI73741.1 - 0.04 13.9 34.1 0.051 13.6 34.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI73741.1 - 0.07 12.7 17.7 0.097 12.3 17.7 1.4 1 0 0 1 1 1 0 Spt20 family PAT1 PF09770.9 CDI73741.1 - 0.72 8.0 14.3 0.75 8.0 14.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MAJIN PF15077.6 CDI73741.1 - 2.2 8.0 6.3 3.2 7.5 6.3 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein GvpL_GvpF PF06386.11 CDI73741.1 - 4.3 7.2 14.4 0.36 10.7 9.6 1.6 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Presenilin PF01080.17 CDI73741.1 - 8.9 5.0 7.7 9.2 4.9 7.7 1.2 1 0 0 1 1 1 0 Presenilin Presenilin PF01080.17 CDI73742.1 - 0.00023 20.0 10.4 0.00023 20.0 10.4 8.3 4 2 1 5 5 5 1 Presenilin RskA PF10099.9 CDI73742.1 - 0.00082 19.7 15.4 0.00082 19.7 15.4 15.2 4 4 6 11 11 11 5 Anti-sigma-K factor rskA N6_N4_Mtase PF01555.18 CDI73742.1 - 0.003 17.3 0.0 13 5.4 0.0 5.0 4 2 0 4 4 4 1 DNA methylase Spt20 PF12090.8 CDI73742.1 - 0.0054 16.4 13.5 0.0054 16.4 13.5 11.7 7 4 2 9 9 9 2 Spt20 family DUF1645 PF07816.11 CDI73742.1 - 0.011 16.3 2.2 0.011 16.3 2.2 10.6 6 5 1 7 7 7 0 Protein of unknown function (DUF1645) DUF3157 PF11355.8 CDI73743.1 - 0.032 13.8 0.4 0.032 13.8 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3157) SUIM_assoc PF16619.5 CDI73743.1 - 0.05 13.7 0.0 0.05 13.7 0.0 3.7 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF3801 PF12687.7 CDI73743.1 - 0.13 12.3 6.4 0.34 11.0 6.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3801) IMUP PF15761.5 CDI73743.1 - 0.96 10.2 10.6 4.1 8.1 0.8 2.8 2 0 0 2 2 2 0 Immortalisation up-regulated protein PrgI PF12666.7 CDI73743.1 - 3.8 8.3 4.9 8.9 7.1 4.9 1.6 1 0 0 1 1 1 0 PrgI family protein TRAP_alpha PF03896.16 CDI73744.1 - 0.038 13.2 9.8 0.06 12.6 9.8 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Presenilin PF01080.17 CDI73744.1 - 0.12 11.2 37.0 0.14 10.9 37.0 1.0 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 CDI73744.1 - 0.14 10.9 26.9 0.17 10.7 26.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2828 PF11443.8 CDI73744.1 - 0.22 9.6 28.7 0.26 9.4 28.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CLN3 PF02487.17 CDI73744.1 - 0.26 10.3 22.2 0.4 9.7 22.2 1.3 1 0 0 1 1 1 0 CLN3 protein Neur_chan_memb PF02932.16 CDI73744.1 - 0.33 11.0 26.1 0.4 10.7 26.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI73744.1 - 0.6 8.9 26.5 0.7 8.6 26.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Rtf2 PF04641.12 CDI73744.1 - 0.88 8.9 24.4 1.1 8.5 24.4 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Gti1_Pac2 PF09729.9 CDI73744.1 - 0.97 9.5 27.0 1.5 8.9 27.0 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family SLC12 PF03522.15 CDI73744.1 - 1.2 8.1 34.1 1.4 7.8 34.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SID-1_RNA_chan PF13965.6 CDI73744.1 - 1.2 7.4 18.1 1.5 7.2 18.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Velvet PF11754.8 CDI73744.1 - 1.5 8.7 31.1 1.9 8.4 31.1 1.1 1 0 0 1 1 1 0 Velvet factor DUF2052 PF09747.9 CDI73744.1 - 1.7 8.7 30.1 2 8.5 30.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF3295 PF11702.8 CDI73744.1 - 1.9 7.7 29.0 2.3 7.5 29.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Otopetrin PF03189.13 CDI73744.1 - 2.4 6.9 22.1 3 6.6 22.2 1.1 1 0 0 1 1 1 0 Otopetrin ExbD PF02472.16 CDI73744.1 - 3.2 7.9 13.9 4.2 7.5 13.9 1.3 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR CDC45 PF02724.14 CDI73744.1 - 3.9 5.6 30.2 4.2 5.5 30.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Endostatin PF06482.11 CDI73744.1 - 4.1 6.8 32.7 5.3 6.4 32.7 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF4569 PF15133.6 CDI73744.1 - 4.3 7.0 34.5 5.8 6.5 34.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) RR_TM4-6 PF06459.12 CDI73744.1 - 5.2 6.8 35.3 6.4 6.5 35.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DREPP PF05558.12 CDI73744.1 - 5.7 6.8 5.8 7.7 6.3 5.8 1.2 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Peptidase_S64 PF08192.11 CDI73744.1 - 6 5.2 29.3 6.7 5.1 29.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 XRN_M PF17846.1 CDI73744.1 - 9.8 5.0 25.7 12 4.7 25.7 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Surface_antigen PF11054.8 CDI73745.1 - 7.3e-24 84.8 5.9 1.2e-22 80.8 6.9 2.1 2 0 0 2 2 2 1 Sporozoite TA4 surface antigen DUF908 PF06012.12 CDI73745.1 - 0.44 9.9 6.4 0.52 9.7 6.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Dicty_REP PF05086.12 CDI73745.1 - 5.9 4.7 9.9 7.8 4.3 9.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RskA PF10099.9 CDI73746.1 - 0.00096 19.5 5.0 0.00096 19.5 5.0 28.9 3 2 18 21 21 21 1 Anti-sigma-K factor rskA AAA_23 PF13476.6 CDI73747.1 - 0.0014 19.2 10.2 0.0016 19.0 10.2 1.2 1 0 0 1 1 1 1 AAA domain RskA PF10099.9 CDI73747.1 - 0.003 17.9 2.4 0.003 17.9 2.4 2.1 1 1 1 2 2 2 1 Anti-sigma-K factor rskA LAP1C PF05609.12 CDI73747.1 - 0.068 12.3 23.8 0.082 12.0 23.8 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Lin-8 PF03353.15 CDI73747.1 - 0.15 11.6 22.8 0.12 11.9 10.7 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Cwf_Cwc_15 PF04889.12 CDI73747.1 - 0.15 11.8 20.3 0.65 9.7 9.2 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Jiraiya PF15038.6 CDI73747.1 - 0.28 10.6 1.7 0.65 9.4 1.7 1.6 1 0 0 1 1 1 0 Jiraiya Peptidase_S64 PF08192.11 CDI73747.1 - 0.61 8.5 24.0 0.72 8.3 24.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 CobT PF06213.12 CDI73747.1 - 0.77 9.1 25.2 0.97 8.8 4.4 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF2076 PF09849.9 CDI73747.1 - 1.2 9.2 31.1 0.044 13.8 7.5 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) MPM1 PF17234.2 CDI73747.1 - 1.9 8.7 21.9 4.4 7.5 8.9 2.3 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 SOG2 PF10428.9 CDI73747.1 - 2.2 7.4 29.5 2.8 7.1 29.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF572 PF04502.13 CDI73747.1 - 6.3 6.3 29.1 6.9 6.2 19.7 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF572) Na_trans_assoc PF06512.13 CDI73747.1 - 6.6 7.0 18.1 8.8 6.6 10.2 2.1 2 0 0 2 2 2 0 Sodium ion transport-associated EMC3_TMCO1 PF01956.16 CDI73747.1 - 9.2 6.0 12.6 8.4 6.1 2.2 2.1 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Pex14_N PF04695.13 CDI73748.1 - 0.065 13.9 20.0 0.066 13.9 20.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Coilin_N PF15862.5 CDI73748.1 - 0.11 12.2 13.5 0.14 11.9 13.5 1.3 1 0 0 1 1 1 0 Coilin N-terminus Baculo_PP31 PF05311.11 CDI73748.1 - 0.2 11.1 11.3 0.2 11.1 11.3 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) RR_TM4-6 PF06459.12 CDI73748.1 - 0.39 10.5 13.3 0.4 10.5 13.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 CDI73748.1 - 0.5 10.5 12.1 0.55 10.4 12.1 1.1 1 0 0 1 1 1 0 DDHD domain eIF-3_zeta PF05091.12 CDI73748.1 - 0.72 8.8 21.1 0.7 8.8 21.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CCDC53 PF10152.9 CDI73748.1 - 0.75 10.2 15.3 0.85 10.0 15.3 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex CobT PF06213.12 CDI73748.1 - 0.8 9.0 20.7 0.81 9.0 20.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MecA PF05389.12 CDI73748.1 - 0.87 9.2 10.4 0.99 9.0 10.4 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) TFIIA PF03153.13 CDI73748.1 - 1.1 9.2 35.6 1.1 9.1 35.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2828 PF11443.8 CDI73748.1 - 1.2 7.2 13.7 1.3 7.0 13.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Paf1 PF03985.13 CDI73748.1 - 1.2 8.1 18.1 1.3 7.9 18.1 1.0 1 0 0 1 1 1 0 Paf1 Neur_chan_memb PF02932.16 CDI73748.1 - 1.2 9.1 9.0 1.2 9.2 9.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_U57 PF05582.12 CDI73748.1 - 1.2 8.3 9.5 1.4 8.2 9.5 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Presenilin PF01080.17 CDI73748.1 - 1.3 7.7 17.1 1.3 7.7 17.1 1.0 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CDI73748.1 - 1.5 8.7 18.1 1.7 8.6 18.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CPSF100_C PF13299.6 CDI73748.1 - 1.6 8.9 11.7 1.7 8.8 11.7 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF1980 PF09323.10 CDI73748.1 - 1.6 8.6 9.3 1.6 8.6 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) EOS1 PF12326.8 CDI73748.1 - 1.6 8.6 7.5 1.6 8.6 7.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein Peptidase_S49_N PF08496.10 CDI73748.1 - 1.7 8.7 11.7 2 8.5 11.7 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FAM60A PF15396.6 CDI73748.1 - 1.9 8.5 10.5 1.9 8.4 10.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SpoIIP PF07454.11 CDI73748.1 - 2 7.8 16.9 2.1 7.7 16.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) AIF_C PF14721.6 CDI73748.1 - 2.7 8.4 10.7 3 8.2 10.7 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Connexin PF00029.19 CDI73748.1 - 2.7 7.7 11.0 2.6 7.7 11.0 1.1 1 0 0 1 1 1 0 Connexin DUF913 PF06025.12 CDI73748.1 - 3.1 6.7 8.3 3.1 6.7 8.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Membralin PF09746.9 CDI73748.1 - 3.2 6.7 7.4 3 6.8 7.4 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF1682 PF07946.14 CDI73748.1 - 3.2 6.9 13.1 3.1 6.9 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) MMR1 PF08505.10 CDI73748.1 - 3.3 7.9 17.6 3.4 7.9 17.6 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein EIIBC-GUT_N PF03612.14 CDI73748.1 - 3.5 7.3 13.9 4.4 7.0 13.9 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Band_3_cyto PF07565.13 CDI73748.1 - 3.6 7.3 15.0 4.1 7.1 15.0 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MDM10 PF12519.8 CDI73748.1 - 3.8 6.3 10.8 3.5 6.4 10.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 RICTOR_N PF14664.6 CDI73748.1 - 3.9 6.3 7.5 4.3 6.2 7.5 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term TERB2 PF15101.6 CDI73748.1 - 4.2 7.4 21.0 4.8 7.2 21.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Ctr PF04145.15 CDI73748.1 - 4.3 8.0 7.9 4.1 8.0 7.9 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Peroxin-13_N PF04088.13 CDI73748.1 - 5.1 7.4 9.2 5.3 7.3 9.2 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF4175 PF13779.6 CDI73748.1 - 5.3 4.8 34.5 5.2 4.9 34.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ALMT PF11744.8 CDI73748.1 - 5.7 5.7 10.0 5.1 5.8 10.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3408 PF11888.8 CDI73748.1 - 6.7 6.9 16.0 8.1 6.6 16.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) SID-1_RNA_chan PF13965.6 CDI73748.1 - 7.2 4.9 6.4 6.7 5.0 6.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI73748.1 - 7.6 4.3 15.0 7.7 4.3 15.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Hid1 PF12722.7 CDI73748.1 - 9.1 4.3 14.2 9.7 4.2 14.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Spt20 PF12090.8 CDI73749.1 - 0.0003 20.5 8.7 0.0003 20.5 8.7 5.9 5 1 0 5 5 5 3 Spt20 family DUF2722 PF10846.8 CDI73749.1 - 0.00091 18.3 4.7 0.00091 18.3 4.7 6.3 4 2 1 5 5 5 1 Protein of unknown function (DUF2722) DUF1644 PF07800.12 CDI73749.1 - 0.022 14.8 1.8 0.022 14.8 1.8 5.3 5 1 0 5 5 5 0 Protein of unknown function (DUF1644) Dala_Dala_lig_N PF01820.21 CDI73749.1 - 0.046 14.2 8.2 17 6.0 0.1 4.7 3 2 0 3 3 3 0 D-ala D-ala ligase N-terminus DUF4770 PF15994.5 CDI73749.1 - 0.063 13.5 0.6 0.063 13.5 0.6 5.4 5 0 0 5 5 5 0 Domain of unknown function (DUF4770) DUF3314 PF11771.8 CDI73749.1 - 9.4 6.3 11.7 7.6 6.6 2.2 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF3314) Spt20 PF12090.8 CDI73751.1 - 9.2e-05 22.2 27.2 0.0016 18.1 11.0 2.2 2 0 0 2 2 2 2 Spt20 family Androgen_recep PF02166.16 CDI73751.1 - 0.00054 18.9 6.3 0.00054 18.9 6.3 4.2 3 1 1 4 4 4 2 Androgen receptor Med15 PF09606.10 CDI73751.1 - 0.0065 15.2 21.1 0.027 13.2 8.3 2.2 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal ANAPC_CDC26 PF10471.9 CDI73751.1 - 0.011 16.5 3.8 0.011 16.5 3.8 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 DUF4834 PF16118.5 CDI73751.1 - 0.91 10.5 12.2 2 9.4 2.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) WBP-1 PF11669.8 CDI73751.1 - 2.4 8.8 7.1 5.2 7.8 0.5 2.7 2 0 0 2 2 2 0 WW domain-binding protein 1 CNDH2_M PF16869.5 CDI73751.1 - 8.2 7.1 9.1 17 6.1 3.4 2.9 2 1 0 2 2 2 0 PF16858 TraG_N PF07916.11 CDI73752.1 - 0.014 14.2 0.1 0.014 14.2 0.1 1.4 2 0 0 2 2 2 0 TraG-like protein, N-terminal region TFIIA PF03153.13 CDI73752.1 - 0.56 10.2 15.5 0.12 12.4 3.2 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit CDK2AP PF09806.9 CDI73752.1 - 0.81 9.7 10.0 0.88 9.6 2.8 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Tic110 PF16940.5 CDI73752.1 - 0.84 8.1 6.3 1.1 7.6 6.3 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter Med3 PF11593.8 CDI73752.1 - 2.5 7.2 24.2 1.3 8.1 7.1 2.1 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal RskA PF10099.9 CDI73752.1 - 3.9 7.7 18.2 11 6.3 12.9 2.4 2 0 0 2 2 2 0 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI73752.1 - 6.2 7.0 18.8 0.057 13.5 8.1 2.9 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 CTU2 PF10288.9 CDI73753.1 - 0.029 14.6 11.0 0.034 14.4 11.0 1.1 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 tRNA-synt_1c PF00749.21 CDI73753.1 - 0.11 11.4 5.6 0.12 11.3 5.6 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain Eapp_C PF10238.9 CDI73753.1 - 0.13 12.4 11.6 0.13 12.3 11.6 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein Pal1 PF08316.11 CDI73753.1 - 0.13 13.0 4.4 0.16 12.7 4.4 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein Orf78 PF06024.12 CDI73753.1 - 0.21 11.9 6.2 0.24 11.7 6.2 1.1 1 0 0 1 1 1 0 Orf78 (ac78) Presenilin PF01080.17 CDI73753.1 - 0.28 9.9 14.9 0.3 9.8 14.9 1.0 1 0 0 1 1 1 0 Presenilin Rxt3 PF08642.10 CDI73753.1 - 0.31 11.8 5.8 0.31 11.8 5.8 1.1 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 MDM31_MDM32 PF08118.11 CDI73753.1 - 0.36 9.4 7.4 0.38 9.4 7.4 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins TFB6 PF17110.5 CDI73753.1 - 0.41 10.4 6.0 0.42 10.3 6.0 1.0 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH FAM176 PF14851.6 CDI73753.1 - 0.42 10.3 6.1 0.46 10.1 6.1 1.1 1 0 0 1 1 1 0 FAM176 family REC114-like PF15165.6 CDI73753.1 - 0.48 10.2 17.8 0.55 10.0 17.8 1.1 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like AIF_C PF14721.6 CDI73753.1 - 0.53 10.6 9.7 0.59 10.5 9.7 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF2126 PF09899.9 CDI73753.1 - 0.54 8.3 11.7 0.55 8.2 11.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Connexin PF00029.19 CDI73753.1 - 0.59 9.9 9.0 0.56 9.9 9.0 1.0 1 0 0 1 1 1 0 Connexin DUF2370 PF10176.9 CDI73753.1 - 0.6 9.7 6.7 0.65 9.6 6.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) CPSF100_C PF13299.6 CDI73753.1 - 0.61 10.2 10.0 0.64 10.2 10.0 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal EIIBC-GUT_N PF03612.14 CDI73753.1 - 0.73 9.6 11.8 0.76 9.5 11.8 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus FAM60A PF15396.6 CDI73753.1 - 0.79 9.7 8.5 0.82 9.6 8.5 1.0 1 0 0 1 1 1 0 Protein Family FAM60A MMU163 PF17119.5 CDI73753.1 - 0.81 8.8 5.8 0.89 8.7 5.8 1.0 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis RR_TM4-6 PF06459.12 CDI73753.1 - 0.91 9.3 12.4 0.94 9.2 12.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TERB2 PF15101.6 CDI73753.1 - 0.94 9.5 18.3 0.98 9.4 18.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Gti1_Pac2 PF09729.9 CDI73753.1 - 0.98 9.5 9.4 0.99 9.5 9.4 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family DUF3464 PF11947.8 CDI73753.1 - 1 9.1 15.4 1.1 9.0 15.4 1.0 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 OATP PF03137.20 CDI73753.1 - 1.1 7.4 10.3 1.2 7.3 10.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family PIP5K PF01504.18 CDI73753.1 - 1.2 8.3 10.2 1.1 8.4 10.2 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase SpoIIP PF07454.11 CDI73753.1 - 1.2 8.6 15.9 1.2 8.5 15.9 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) BRF1 PF07741.13 CDI73753.1 - 1.3 9.4 11.9 1.4 9.3 11.9 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Peroxin-13_N PF04088.13 CDI73753.1 - 1.3 9.3 7.0 1.4 9.2 7.0 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Folate_carrier PF01770.18 CDI73753.1 - 1.3 7.7 8.0 1.4 7.6 8.0 1.0 1 0 0 1 1 1 0 Reduced folate carrier WASH-7_C PF14746.6 CDI73753.1 - 1.5 8.5 12.3 1.7 8.3 12.3 1.2 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal Kei1 PF08552.11 CDI73753.1 - 1.6 8.6 7.5 1.6 8.6 7.5 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF3408 PF11888.8 CDI73753.1 - 1.7 8.8 14.3 1.8 8.7 14.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF4834 PF16118.5 CDI73753.1 - 1.8 9.6 17.0 2.6 9.1 17.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) RPA43_OB PF17875.1 CDI73753.1 - 1.8 9.2 9.6 2 9.0 9.6 1.1 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Tim54 PF11711.8 CDI73753.1 - 1.8 7.2 13.0 2 7.1 13.0 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CRF1 PF10380.9 CDI73753.1 - 1.9 8.9 7.0 2.3 8.6 7.0 1.2 1 0 0 1 1 1 0 Transcription factor CRF1 CSG2 PF16965.5 CDI73753.1 - 1.9 7.4 6.8 1.8 7.4 6.8 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 CDI73753.1 - 1.9 7.4 10.5 1.9 7.5 10.5 1.0 1 0 0 1 1 1 0 CLN3 protein DDHD PF02862.17 CDI73753.1 - 2 8.5 12.5 2.1 8.5 12.5 1.0 1 0 0 1 1 1 0 DDHD domain ORC_WH_C PF18137.1 CDI73753.1 - 2.1 8.4 11.8 2.3 8.3 11.8 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal DUF5308 PF17233.2 CDI73753.1 - 2.1 8.5 14.5 2.3 8.4 14.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Renin_r PF07850.14 CDI73753.1 - 2.1 9.0 4.9 2.5 8.7 4.9 1.2 1 0 0 1 1 1 0 Renin receptor-like protein Sec62 PF03839.16 CDI73753.1 - 2.2 7.8 8.5 2.2 7.7 8.5 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 Spt20 PF12090.8 CDI73753.1 - 2.2 7.8 44.8 2.7 7.5 44.8 1.2 1 0 0 1 1 1 0 Spt20 family EOS1 PF12326.8 CDI73753.1 - 2.7 7.9 7.5 2.8 7.8 7.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein DUF2828 PF11443.8 CDI73753.1 - 2.7 6.0 12.6 2.8 5.9 12.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) FlaG PF03646.15 CDI73753.1 - 2.7 8.2 21.0 3.8 7.7 21.0 1.3 1 0 0 1 1 1 0 FlaG protein Paf1 PF03985.13 CDI73753.1 - 2.8 6.8 15.8 3 6.8 15.8 1.0 1 0 0 1 1 1 0 Paf1 Baculo_PP31 PF05311.11 CDI73753.1 - 2.8 7.3 14.8 3 7.2 14.8 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Suf PF05843.14 CDI73753.1 - 2.8 7.8 21.3 2.8 7.8 21.3 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CobT PF06213.12 CDI73753.1 - 2.9 7.2 22.2 3.2 7.1 22.2 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pex26 PF07163.12 CDI73753.1 - 2.9 7.1 14.1 2.9 7.1 14.1 1.0 1 0 0 1 1 1 0 Pex26 protein DUF4770 PF15994.5 CDI73753.1 - 3.4 7.9 17.0 3.9 7.7 17.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Neur_chan_memb PF02932.16 CDI73753.1 - 3.4 7.7 11.4 3.3 7.7 11.4 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ureide_permease PF07168.11 CDI73753.1 - 3.6 6.3 6.2 3.7 6.2 6.2 1.0 1 0 0 1 1 1 0 Ureide permease ALMT PF11744.8 CDI73753.1 - 3.8 6.2 8.8 3.8 6.2 8.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CCDC53 PF10152.9 CDI73753.1 - 3.8 7.9 16.5 4.2 7.8 16.5 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF1943 PF09172.11 CDI73753.1 - 3.8 6.6 10.2 4.3 6.5 10.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Zip PF02535.22 CDI73753.1 - 3.9 6.6 6.1 3.5 6.7 6.1 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter eIF-3_zeta PF05091.12 CDI73753.1 - 3.9 6.3 20.5 3.9 6.4 20.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) V_ATPase_I PF01496.19 CDI73753.1 - 4.1 5.2 14.3 4.3 5.1 14.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MTP18 PF10558.9 CDI73753.1 - 4.2 7.3 5.2 4.2 7.3 5.2 1.1 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) G0-G1_switch_2 PF15103.6 CDI73753.1 - 4.3 7.8 11.0 5 7.6 11.0 1.1 1 0 0 1 1 1 0 G0/G1 switch protein 2 BORG_CEP PF14957.6 CDI73753.1 - 4.4 8.5 10.5 4.6 8.4 10.5 1.1 1 0 0 1 1 1 0 Cdc42 effector Coilin_N PF15862.5 CDI73753.1 - 4.4 7.1 17.0 5.2 6.9 17.0 1.1 1 0 0 1 1 1 0 Coilin N-terminus DUF4457 PF14652.6 CDI73753.1 - 4.8 6.3 10.2 4.8 6.3 10.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) EPL1 PF10513.9 CDI73753.1 - 4.8 7.6 16.0 5.4 7.4 16.0 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF775 PF05603.12 CDI73753.1 - 4.9 6.6 17.0 5.8 6.4 17.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) PAT1 PF09770.9 CDI73753.1 - 5.1 5.2 26.9 5.2 5.2 26.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ctr PF04145.15 CDI73753.1 - 5.5 7.6 8.1 5.9 7.5 8.1 1.1 1 0 0 1 1 1 0 Ctr copper transporter family FHIPEP PF00771.20 CDI73753.1 - 5.6 5.3 10.7 6.1 5.2 10.7 1.0 1 0 0 1 1 1 0 FHIPEP family Band_3_cyto PF07565.13 CDI73753.1 - 6.4 6.5 14.0 6.5 6.5 14.0 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Pex14_N PF04695.13 CDI73753.1 - 6.5 7.4 26.4 7.3 7.2 26.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2076 PF09849.9 CDI73753.1 - 7.9 6.4 30.4 8.7 6.3 30.4 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Peptidase_S49_N PF08496.10 CDI73753.1 - 9.2 6.3 12.8 9.4 6.3 12.8 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal POM121 PF15229.6 CDI73754.1 - 0.026 14.2 4.5 0.027 14.1 4.5 1.0 1 0 0 1 1 1 0 POM121 family FAM76 PF16046.5 CDI73755.1 - 5.4e-05 22.7 7.0 6.8e-05 22.4 7.0 1.1 1 0 0 1 1 1 1 FAM76 protein DDHD PF02862.17 CDI73755.1 - 0.00023 21.4 1.8 0.00023 21.4 1.8 1.1 1 0 0 1 1 1 1 DDHD domain Presenilin PF01080.17 CDI73755.1 - 0.0003 19.7 4.8 0.00043 19.2 4.8 1.3 1 0 0 1 1 1 1 Presenilin Eapp_C PF10238.9 CDI73755.1 - 0.0011 19.0 4.7 0.0016 18.5 4.7 1.2 1 0 0 1 1 1 1 E2F-associated phosphoprotein Es2 PF09751.9 CDI73755.1 - 0.0025 17.6 5.3 0.0031 17.3 5.3 1.1 1 0 0 1 1 1 1 Nuclear protein Es2 SpoIIP PF07454.11 CDI73755.1 - 0.0027 17.2 6.6 0.0037 16.7 6.6 1.3 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Trp_oprn_chp PF09534.10 CDI73755.1 - 0.0045 16.8 4.8 0.0045 16.8 4.8 3.1 1 1 1 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4746 PF15928.5 CDI73755.1 - 0.006 16.1 1.7 0.006 16.0 1.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) DUF4770 PF15994.5 CDI73755.1 - 0.0073 16.6 6.5 0.0089 16.3 6.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4770) EPL1 PF10513.9 CDI73755.1 - 0.0073 16.7 6.4 0.0097 16.3 6.4 1.2 1 0 0 1 1 1 1 Enhancer of polycomb-like DUF4471 PF14740.6 CDI73755.1 - 0.0077 15.5 2.2 0.0084 15.4 2.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4471) RNA12 PF10443.9 CDI73755.1 - 0.0096 14.7 3.8 0.011 14.5 3.8 1.1 1 0 0 1 1 1 1 RNA12 protein Otopetrin PF03189.13 CDI73755.1 - 0.012 14.4 0.2 0.012 14.4 0.2 1.1 1 0 0 1 1 1 0 Otopetrin Gti1_Pac2 PF09729.9 CDI73755.1 - 0.013 15.7 4.3 0.015 15.4 4.3 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Pex14_N PF04695.13 CDI73755.1 - 0.013 16.2 15.5 0.013 16.2 15.5 1.7 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region OATP PF03137.20 CDI73755.1 - 0.016 13.5 0.4 0.018 13.3 0.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family ALMT PF11744.8 CDI73755.1 - 0.017 14.0 2.7 0.019 13.9 2.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 CDI73755.1 - 0.018 15.1 4.0 0.024 14.7 4.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CPSF100_C PF13299.6 CDI73755.1 - 0.022 14.9 6.6 0.041 14.1 6.6 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Peroxin-13_N PF04088.13 CDI73755.1 - 0.027 14.7 4.6 0.05 13.9 4.6 1.4 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Peptidase_U57 PF05582.12 CDI73755.1 - 0.037 13.3 2.6 0.042 13.1 2.6 1.1 1 0 0 1 1 1 0 YabG peptidase U57 SLC12 PF03522.15 CDI73755.1 - 0.039 13.0 7.6 0.048 12.7 7.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF2370 PF10176.9 CDI73755.1 - 0.05 13.2 0.9 0.065 12.9 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) FAM176 PF14851.6 CDI73755.1 - 0.058 13.1 6.0 0.098 12.3 6.0 1.3 1 0 0 1 1 1 0 FAM176 family Connexin PF00029.19 CDI73755.1 - 0.071 12.9 7.0 0.099 12.4 7.0 1.2 1 0 0 1 1 1 0 Connexin Zip PF02535.22 CDI73755.1 - 0.098 11.9 5.8 0.14 11.3 5.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 CDI73755.1 - 0.12 10.6 6.7 0.16 10.3 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Sec62 PF03839.16 CDI73755.1 - 0.14 11.7 4.5 0.19 11.2 4.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 CobT PF06213.12 CDI73755.1 - 0.18 11.2 19.3 0.31 10.4 19.3 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TFIIA PF03153.13 CDI73755.1 - 0.2 11.6 33.1 0.31 11.0 33.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MDM10 PF12519.8 CDI73755.1 - 0.23 10.3 6.6 0.28 10.0 6.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Suf PF05843.14 CDI73755.1 - 0.3 11.0 12.4 0.42 10.5 12.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF913 PF06025.12 CDI73755.1 - 0.5 9.3 6.9 0.7 8.8 6.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2126 PF09899.9 CDI73755.1 - 0.52 8.3 7.7 0.65 8.0 7.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Ctr PF04145.15 CDI73755.1 - 0.57 10.8 7.3 0.97 10.0 7.3 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Ndc1_Nup PF09531.10 CDI73755.1 - 0.68 8.5 6.8 0.078 11.7 2.9 1.5 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup EIIBC-GUT_N PF03612.14 CDI73755.1 - 0.83 9.4 10.6 1.3 8.7 10.6 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus MMR1 PF08505.10 CDI73755.1 - 0.9 9.8 16.8 1.2 9.3 16.8 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Med15 PF09606.10 CDI73755.1 - 1 8.0 29.2 1.8 7.2 29.2 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Serinc PF03348.15 CDI73755.1 - 1.1 8.2 8.9 1.7 7.5 8.9 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) CLN3 PF02487.17 CDI73755.1 - 1.1 8.2 9.5 1.5 7.8 9.5 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4834 PF16118.5 CDI73755.1 - 1.2 10.2 15.6 2.8 9.0 15.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4638 PF15472.6 CDI73755.1 - 1.3 8.7 9.7 1.8 8.2 9.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) FHIPEP PF00771.20 CDI73755.1 - 1.3 7.4 7.3 1.8 6.9 7.3 1.2 1 0 0 1 1 1 0 FHIPEP family Tim54 PF11711.8 CDI73755.1 - 1.5 7.5 10.9 2.1 7.0 10.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 CDI73755.1 - 1.8 8.4 13.0 2.5 7.8 13.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ureide_permease PF07168.11 CDI73755.1 - 2 7.1 4.6 3.1 6.4 4.6 1.3 1 0 0 1 1 1 0 Ureide permease MCU PF04678.13 CDI73755.1 - 2.4 8.2 9.8 4.3 7.4 9.8 1.4 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Pannexin_like PF12534.8 CDI73755.1 - 2.7 7.0 10.5 3.7 6.5 10.5 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 V_ATPase_I PF01496.19 CDI73755.1 - 2.7 5.8 16.4 3.4 5.5 16.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S64 PF08192.11 CDI73755.1 - 2.8 6.3 10.0 3.5 6.0 10.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 Kei1 PF08552.11 CDI73755.1 - 3 7.7 11.9 2.3 8.0 9.7 1.7 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 eIF3_subunit PF08597.10 CDI73755.1 - 3.2 7.6 15.9 0.038 13.9 8.4 1.5 2 0 0 2 2 1 0 Translation initiation factor eIF3 subunit CSG2 PF16965.5 CDI73755.1 - 4.1 6.3 8.5 5.8 5.8 8.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator TFB6 PF17110.5 CDI73755.1 - 4.9 6.9 10.2 7.4 6.3 10.2 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH AIF_C PF14721.6 CDI73755.1 - 5.1 7.5 11.0 7.6 6.9 11.0 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term SID-1_RNA_chan PF13965.6 CDI73755.1 - 6.5 5.0 6.9 8.7 4.6 6.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ORC_WH_C PF18137.1 CDI73755.1 - 8.5 6.4 14.3 13 5.8 14.3 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Folliculin PF11704.8 CDI73755.1 - 8.6 6.2 12.5 13 5.6 12.5 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Orf78 PF06024.12 CDI73755.1 - 8.8 6.7 7.7 17 5.8 7.7 1.5 1 0 0 1 1 1 0 Orf78 (ac78) FAM60A PF15396.6 CDI73755.1 - 8.9 6.2 11.6 15 5.5 11.6 1.3 1 0 0 1 1 1 0 Protein Family FAM60A PAT1 PF09770.9 CDI73755.1 - 9.2 4.4 25.4 12 4.0 25.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2828 PF11443.8 CDI73755.1 - 9.8 4.1 15.1 13 3.8 15.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Macoilin PF09726.9 CDI73756.1 - 0.0077 14.8 35.6 0.012 14.2 35.6 1.2 1 0 0 1 1 1 1 Macoilin family Ribosomal_60s PF00428.19 CDI73756.1 - 0.013 16.0 1.2 0.029 15.0 1.2 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF1980 PF09323.10 CDI73756.1 - 0.06 13.3 0.3 0.06 13.3 0.3 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF1980) Caldesmon PF02029.15 CDI73756.1 - 4.9 5.8 47.5 6.5 5.4 47.5 1.1 1 0 0 1 1 1 0 Caldesmon Tim54 PF11711.8 CDI73757.1 - 0.0022 16.9 6.8 0.0022 16.9 6.8 7.0 6 2 1 7 7 7 1 Inner membrane protein import complex subunit Tim54 NAM-associated PF14303.6 CDI73757.1 - 0.021 15.6 0.0 0.021 15.6 0.0 14.1 9 4 2 11 11 11 0 No apical meristem-associated C-terminal domain FAM104 PF15434.6 CDI73757.1 - 2 9.0 0.0 2 9.0 0.0 15.0 11 4 2 14 14 14 0 Family 104 SR-25 PF10500.9 CDI73758.1 - 6.3e-06 26.0 23.0 6.3e-06 26.0 23.0 3.2 2 1 1 3 3 2 1 Nuclear RNA-splicing-associated protein MID_MedPIWI PF18296.1 CDI73758.1 - 0.00025 20.9 11.1 0.00025 20.9 11.1 2.7 2 1 0 2 2 1 1 MID domain of medPIWI Pex14_N PF04695.13 CDI73758.1 - 0.00034 21.3 17.6 0.00034 21.3 17.6 3.5 2 1 1 3 3 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Nop53 PF07767.11 CDI73758.1 - 0.00094 18.7 9.1 0.00094 18.7 9.1 2.4 2 1 0 2 2 1 1 Nop53 (60S ribosomal biogenesis) CCSAP PF15748.5 CDI73758.1 - 0.0016 18.6 16.1 0.0016 18.6 16.1 2.2 2 0 0 2 2 2 1 Centriole, cilia and spindle-associated SDA1 PF05285.12 CDI73758.1 - 0.0047 16.4 33.8 0.0055 16.2 9.8 2.3 2 0 0 2 2 2 2 SDA1 Zip PF02535.22 CDI73758.1 - 0.0066 15.7 5.9 0.0066 15.7 5.9 2.3 2 0 0 2 2 2 1 ZIP Zinc transporter RskA PF10099.9 CDI73758.1 - 0.007 16.7 14.9 0.007 16.7 14.9 4.6 1 1 3 4 4 1 1 Anti-sigma-K factor rskA Suf PF05843.14 CDI73758.1 - 0.01 15.8 13.0 0.01 15.8 13.0 2.8 2 1 0 2 2 1 0 Suppressor of forked protein (Suf) CNDH2_C PF16858.5 CDI73758.1 - 0.029 14.3 35.5 0.16 11.9 4.5 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Apt1 PF10351.9 CDI73758.1 - 0.045 12.6 37.6 0.17 10.7 11.3 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain DUF4614 PF15391.6 CDI73758.1 - 0.23 11.5 51.2 0.022 14.8 19.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Presenilin PF01080.17 CDI73758.1 - 0.63 8.8 61.1 0.03 13.1 16.5 2.1 2 0 0 2 2 2 0 Presenilin DUF4045 PF13254.6 CDI73758.1 - 0.81 9.3 52.8 0.11 12.1 15.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) SOBP PF15279.6 CDI73758.1 - 0.82 10.2 53.0 0.11 13.1 16.6 2.1 2 0 0 2 2 2 0 Sine oculis-binding protein TT_ORF1 PF02956.14 CDI73758.1 - 1 7.9 27.6 1.1 7.8 12.7 2.2 2 0 0 2 2 2 0 TT viral orf 1 NPR3 PF03666.13 CDI73758.1 - 1.1 8.0 45.4 1 8.1 18.1 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF5427 PF10310.9 CDI73758.1 - 1.5 7.7 56.3 0.19 10.7 16.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5427) LAP1C PF05609.12 CDI73758.1 - 2.5 7.1 51.4 0.2 10.7 17.0 2.0 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Hid1 PF12722.7 CDI73758.1 - 2.9 5.9 52.6 0.063 11.4 15.1 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Endostatin PF06482.11 CDI73758.1 - 3.4 7.0 45.8 0.08 12.4 10.5 2.3 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Tyrosinase PF00264.20 CDI73758.1 - 3.5 7.8 27.2 0.25 11.6 3.1 2.2 2 0 0 2 2 2 0 Common central domain of tyrosinase DUF92 PF01940.16 CDI73758.1 - 5 6.5 10.6 4.8 6.5 0.7 2.4 2 0 0 2 2 2 0 Integral membrane protein DUF92 DUF4207 PF13904.6 CDI73758.1 - 8.7 5.9 87.2 0.33 10.6 24.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) SMYLE_N PF18615.1 CDI73758.1 - 9 5.7 38.7 0.25 10.8 11.4 2.3 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain LRR_9 PF14580.6 CDI73759.1 - 2.8e-28 98.6 11.4 6.1e-13 48.6 0.1 5.4 4 1 1 5 5 5 5 Leucine-rich repeat LRR_8 PF13855.6 CDI73759.1 - 1.8e-24 85.3 37.8 6.4e-05 22.6 0.0 8.3 8 0 0 8 8 8 6 Leucine rich repeat LRR_4 PF12799.7 CDI73759.1 - 6.5e-21 74.1 47.6 2.4e-05 24.6 0.5 9.9 6 3 7 13 13 13 10 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDI73759.1 - 0.042 13.9 16.6 11 6.4 0.1 7.7 8 0 0 8 8 8 0 Leucine Rich repeat LRR_1 PF00560.33 CDI73759.1 - 8.5 7.4 34.3 12 6.9 0.2 9.7 8 1 1 9 9 9 0 Leucine Rich Repeat LRR_4 PF12799.7 CDI73760.1 - 2.5e-09 37.3 13.5 0.00048 20.5 0.6 4.2 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI73760.1 - 6.2e-08 32.3 11.9 0.0002 21.1 6.3 2.6 2 0 0 2 2 2 2 Leucine rich repeat DUF2379 PF09543.10 CDI73760.1 - 0.074 13.2 0.2 0.16 12.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2379) LRR_9 PF14580.6 CDI73760.1 - 0.23 11.0 1.3 1.7 8.1 0.4 2.1 2 0 0 2 2 2 0 Leucine-rich repeat Dynein_C PF18199.1 CDI73763.1 - 8.5e-80 268.2 0.0 2.3e-79 266.8 0.0 1.7 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 CDI73763.1 - 6.7e-77 257.5 5.1 7e-73 244.4 0.2 3.0 2 1 1 3 3 3 2 ATP-binding dynein motor region AAA_lid_11 PF18198.1 CDI73763.1 - 2.6e-43 147.7 0.0 1.3e-41 142.2 0.0 2.4 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 CDI73763.1 - 9.4e-37 125.7 0.0 2.4e-35 121.2 0.0 3.1 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 CDI73763.1 - 4.4e-14 52.3 0.1 8.3e-14 51.4 0.1 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor GARP PF16731.5 CDI73763.1 - 0.1 12.2 4.4 0.75 9.5 0.1 2.9 3 0 0 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma Phage_Gp23 PF10669.9 CDI73764.1 - 0.052 13.9 0.8 0.092 13.1 0.8 1.4 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) PBP_N PF17093.5 CDI73765.1 - 0.93 9.7 4.2 0.29 11.4 0.3 2.2 2 1 0 2 2 2 0 Penicillin-binding protein N-terminus EF-hand_1 PF00036.32 CDI73766.1 - 1.8e-30 102.2 2.2 3.8e-07 29.2 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 CDI73766.1 - 1.7e-28 96.8 4.4 1.3e-07 30.8 0.0 5.1 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 CDI73766.1 - 2.8e-24 82.9 2.5 2.9e-05 23.6 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 CDI73766.1 - 1.2e-23 83.3 0.5 2.5e-11 43.9 0.2 3.1 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CDI73766.1 - 8.4e-18 64.0 1.9 7.6e-06 25.7 0.0 4.3 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDI73766.1 - 1.3e-08 35.1 0.3 0.00092 19.5 0.0 3.0 2 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Pkinase PF00069.25 CDI73766.1 - 1.4e-08 34.4 0.0 2.3e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain EF-hand_4 PF12763.7 CDI73766.1 - 3.8e-08 33.2 0.7 0.0031 17.5 0.1 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Excalibur PF05901.11 CDI73766.1 - 0.0072 16.9 0.4 20 5.9 0.0 3.5 3 0 0 3 3 3 0 Excalibur calcium-binding domain Med24_N PF11277.8 CDI73766.1 - 0.032 12.3 1.1 0.14 10.2 0.1 1.9 1 1 0 2 2 2 0 Mediator complex subunit 24 N-terminal EF-hand_10 PF14788.6 CDI73766.1 - 0.054 13.4 0.0 3.3 7.6 0.0 3.0 3 0 0 3 3 3 0 EF hand DUF892 PF05974.12 CDI73766.1 - 0.15 12.1 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF892) Dockerin_1 PF00404.18 CDI73766.1 - 0.87 9.8 3.5 83 3.5 0.6 3.6 3 1 1 4 4 4 0 Dockerin type I domain RskA PF10099.9 CDI73767.1 - 0.00015 22.1 1.1 0.00015 22.1 1.1 5.2 1 1 4 5 5 5 3 Anti-sigma-K factor rskA DUF4231 PF14015.6 CDI73767.1 - 0.69 10.4 13.3 1.7 9.2 0.4 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF4231) CD20 PF04103.15 CDI73768.1 - 0.2 11.8 0.1 0.2 11.8 0.1 3.6 2 1 1 3 3 3 0 CD20-like family NAD_kinase PF01513.21 CDI73769.1 - 0.034 13.4 0.1 0.041 13.1 0.1 1.1 1 0 0 1 1 1 0 ATP-NAD kinase RLL PF10036.9 CDI73769.1 - 0.041 13.7 12.2 0.051 13.4 12.2 1.1 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein BAF1_ABF1 PF04684.13 CDI73769.1 - 0.25 10.4 14.5 0.3 10.1 14.5 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Ribosomal_60s PF00428.19 CDI73769.1 - 0.37 11.4 8.7 0.61 10.7 8.7 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein PCM1_C PF15717.5 CDI73769.1 - 1.8 7.1 14.1 2.1 6.9 14.1 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus DUF3292 PF11696.8 CDI73769.1 - 2.4 6.4 13.0 2.9 6.1 13.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF5427 PF10310.9 CDI73769.1 - 2.7 6.9 19.5 3.3 6.5 19.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Suf PF05843.14 CDI73769.1 - 3 7.7 23.6 4.2 7.3 23.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) GPCR_chapero_1 PF11904.8 CDI73769.1 - 3.2 7.1 9.0 3.8 6.9 9.0 1.0 1 0 0 1 1 1 0 GPCR-chaperone ABC2_membrane_2 PF12679.7 CDI73769.1 - 4.5 6.5 5.2 5.5 6.2 5.2 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Presenilin PF01080.17 CDI73769.1 - 9.4 4.9 19.6 12 4.5 19.6 1.1 1 0 0 1 1 1 0 Presenilin BAF1_ABF1 PF04684.13 CDI73770.1 - 0.026 13.6 11.3 0.035 13.2 11.3 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF819 PF05684.12 CDI73770.1 - 0.033 13.2 3.1 0.05 12.6 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF819) TAF4 PF05236.14 CDI73770.1 - 0.046 13.5 23.6 0.099 12.4 23.6 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Ferlin_C PF16165.5 CDI73770.1 - 0.082 12.8 3.6 0.14 12.1 3.6 1.5 1 0 0 1 1 1 0 Ferlin C-terminus L6_membrane PF05805.12 CDI73770.1 - 0.099 12.2 0.7 0.15 11.7 0.4 1.4 1 1 0 1 1 1 0 L6 membrane protein DUF3295 PF11702.8 CDI73770.1 - 0.23 10.8 16.6 0.24 10.7 16.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) FAM60A PF15396.6 CDI73770.1 - 0.31 11.0 11.9 0.44 10.5 11.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SLC12 PF03522.15 CDI73770.1 - 0.59 9.1 19.7 0.76 8.7 19.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 TT_ORF1 PF02956.14 CDI73770.1 - 0.6 8.7 11.5 0.81 8.3 11.5 1.1 1 0 0 1 1 1 0 TT viral orf 1 DUF543 PF04418.12 CDI73770.1 - 0.7 9.9 2.4 2.9 7.9 2.4 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF543) DUF2207 PF09972.9 CDI73770.1 - 0.81 8.4 1.8 1.3 7.7 1.8 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) GREB1 PF15782.5 CDI73770.1 - 2.9 4.9 20.7 3.6 4.6 20.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_S64 PF08192.11 CDI73770.1 - 3.3 6.1 15.2 3.6 6.0 15.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 MMU163 PF17119.5 CDI73770.1 - 3.4 6.8 12.7 3.1 6.9 12.0 1.3 1 1 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DUF2052 PF09747.9 CDI73770.1 - 4.5 7.3 20.7 7.1 6.7 20.7 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) GPCR_chapero_1 PF11904.8 CDI73770.1 - 4.8 6.5 11.7 6.1 6.2 11.7 1.1 1 0 0 1 1 1 0 GPCR-chaperone Tox-WTIP PF15654.6 CDI73770.1 - 5.2 7.6 4.7 13 6.3 4.7 1.7 1 0 0 1 1 1 0 Toxin with a conserved tryptophan and TIP tripeptide motif DUF3112 PF11309.8 CDI73770.1 - 5.4 6.4 6.8 8.9 5.7 6.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) ALMT PF11744.8 CDI73770.1 - 9.3 4.9 17.2 12 4.5 17.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SID-1_RNA_chan PF13965.6 CDI73771.1 - 0.0044 15.5 0.0 0.0044 15.5 0.0 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 VIR_N PF15912.5 CDI73771.1 - 0.073 12.7 7.0 0.081 12.5 7.0 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DUF5308 PF17233.2 CDI73771.1 - 0.093 13.0 9.3 0.12 12.6 9.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5308) CPSF100_C PF13299.6 CDI73771.1 - 0.096 12.9 13.0 0.11 12.7 13.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 CDI73771.1 - 0.16 10.7 20.2 0.18 10.5 20.2 1.0 1 0 0 1 1 1 0 Presenilin RNA_pol_Rpc4 PF05132.14 CDI73771.1 - 0.16 12.4 15.7 0.19 12.1 15.7 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF913 PF06025.12 CDI73771.1 - 0.37 9.7 9.7 0.42 9.5 9.7 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4746 PF15928.5 CDI73771.1 - 0.56 9.6 12.0 0.65 9.4 12.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Gti1_Pac2 PF09729.9 CDI73771.1 - 0.58 10.2 15.5 0.66 10.0 15.5 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family SpoIIP PF07454.11 CDI73771.1 - 0.64 9.4 20.8 0.72 9.3 20.8 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Endostatin PF06482.11 CDI73771.1 - 1 8.8 15.3 1.1 8.6 15.3 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin RR_TM4-6 PF06459.12 CDI73771.1 - 1 9.1 22.0 1.2 8.9 22.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BORG_CEP PF14957.6 CDI73771.1 - 1.1 10.4 11.2 1.4 10.1 11.2 1.1 1 0 0 1 1 1 0 Cdc42 effector Peptidase_U57 PF05582.12 CDI73771.1 - 1.2 8.4 13.3 1.3 8.2 13.3 1.0 1 0 0 1 1 1 0 YabG peptidase U57 Connexin PF00029.19 CDI73771.1 - 1.2 8.8 17.2 1.4 8.7 17.2 1.0 1 0 0 1 1 1 0 Connexin Pex14_N PF04695.13 CDI73771.1 - 1.6 9.4 25.4 2 9.0 25.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region eIF-3_zeta PF05091.12 CDI73771.1 - 1.8 7.5 25.3 1.9 7.3 25.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM176 PF14851.6 CDI73771.1 - 2.4 7.8 12.5 2.9 7.6 12.5 1.1 1 0 0 1 1 1 0 FAM176 family V_ATPase_I PF01496.19 CDI73771.1 - 2.6 5.9 21.1 3.1 5.6 21.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family XRCC4 PF06632.12 CDI73771.1 - 3.5 6.4 21.3 4.4 6.1 21.3 1.0 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF3408 PF11888.8 CDI73771.1 - 5.7 7.1 21.3 7.5 6.7 21.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) CCDC53 PF10152.9 CDI73771.1 - 5.7 7.3 20.2 6.8 7.1 20.2 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF3292 PF11696.8 CDI73771.1 - 6.2 5.1 13.2 6.5 5.0 13.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DDHD PF02862.17 CDI73771.1 - 9.4 6.3 18.8 11 6.1 18.8 1.1 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 CDI73771.1 - 9.9 6.1 15.3 12 5.8 15.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RAB3GAP2_N PF14655.6 CDI73772.1 - 0.28 10.4 5.1 0.39 9.9 5.1 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF1682 PF07946.14 CDI73773.1 - 0.086 12.0 10.1 0.096 11.9 10.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CCSAP PF15748.5 CDI73773.1 - 1.2 9.3 29.4 0.56 10.3 27.8 1.3 1 1 0 1 1 1 0 Centriole, cilia and spindle-associated Folate_carrier PF01770.18 CDI73773.1 - 1.6 7.4 8.7 1.6 7.4 8.7 1.3 1 0 0 1 1 1 0 Reduced folate carrier Serinc PF03348.15 CDI73773.1 - 1.9 7.3 10.3 2 7.3 10.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Caldesmon PF02029.15 CDI73774.1 - 6.1 5.5 71.4 0.72 8.5 18.6 2.4 2 0 0 2 2 2 0 Caldesmon AF-4 PF05110.13 CDI73775.1 - 0.0011 17.2 43.0 0.0013 17.0 43.0 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Afi1 PF07792.12 CDI73775.1 - 0.0041 17.6 22.6 0.0041 17.6 22.6 2.2 1 1 1 2 2 2 1 Docking domain of Afi1 for Arf3 in vesicle trafficking PPDFL PF15060.6 CDI73775.1 - 0.0059 17.1 11.8 0.0059 17.1 11.8 3.2 1 1 2 3 3 3 1 Differentiation and proliferation regulator AMP-binding PF00501.28 CDI73775.1 - 6.8 5.2 11.8 0.42 9.1 7.0 1.4 2 0 0 2 2 2 0 AMP-binding enzyme BAF1_ABF1 PF04684.13 CDI73776.1 - 0.92 8.5 23.0 1.2 8.1 23.0 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Peroxin-3 PF04882.12 CDI73776.1 - 1.7 7.5 30.1 2.1 7.2 30.1 1.0 1 0 0 1 1 1 0 Peroxin-3 Endomucin PF07010.12 CDI73777.1 - 2.6 8.0 29.7 3.4 7.6 29.7 1.1 1 0 0 1 1 1 0 Endomucin Hamartin PF04388.12 CDI73777.1 - 2.7 6.6 10.4 2.9 6.5 10.4 1.0 1 0 0 1 1 1 0 Hamartin protein DUF4569 PF15133.6 CDI73777.1 - 2.7 7.6 5.6 3.3 7.3 5.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) GREB1 PF15782.5 CDI73777.1 - 3.2 4.7 19.7 3.6 4.6 19.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF812 PF05667.11 CDI73777.1 - 3.6 6.4 16.0 4.3 6.1 16.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF4045 PF13254.6 CDI73777.1 - 5.8 6.4 19.4 7.3 6.1 19.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) NAM-associated PF14303.6 CDI73779.1 - 0.6 10.8 0.0 0.6 10.8 0.0 5.9 1 1 2 4 4 4 0 No apical meristem-associated C-terminal domain tRNA_bind PF01588.20 CDI73780.1 - 9.7e-24 83.3 0.0 2.1e-23 82.2 0.0 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain DUF2722 PF10846.8 CDI73780.1 - 0.0002 20.5 4.0 0.00025 20.1 4.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI73780.1 - 0.00039 20.1 8.7 0.00054 19.7 8.7 1.2 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 CDI73780.1 - 0.001 19.2 6.1 0.0012 19.0 6.1 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit GST_C_3 PF14497.6 CDI73780.1 - 0.01 16.0 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CDI73780.1 - 0.019 15.1 0.1 0.049 13.9 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain FTZ PF03867.14 CDI73780.1 - 0.028 14.0 1.9 0.046 13.3 1.9 1.3 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region GST_C_2 PF13410.6 CDI73780.1 - 0.063 13.3 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Topoisom_I_N PF02919.15 CDI73780.1 - 0.075 12.5 0.9 0.11 11.9 0.9 1.2 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment EphA2_TM PF14575.6 CDI73780.1 - 0.22 12.4 0.7 0.45 11.4 0.7 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Activator_LAG-3 PF11498.8 CDI73780.1 - 0.87 8.5 22.1 1.2 8.0 22.1 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DivIC PF04977.15 CDI73780.1 - 6.2 6.7 9.6 13 5.7 9.6 1.4 1 0 0 1 1 1 0 Septum formation initiator Med3 PF11593.8 CDI73780.1 - 6.3 5.9 24.4 0.037 13.2 15.1 1.8 1 1 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4604 PF15377.6 CDI73781.1 - 0.56 10.6 33.5 0.71 10.3 33.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) YL1 PF05764.13 CDI73781.1 - 0.6 10.2 40.3 0.68 10.0 40.3 1.0 1 0 0 1 1 1 0 YL1 nuclear protein BUD22 PF09073.10 CDI73781.1 - 1.2 8.4 29.5 1.2 8.4 29.5 1.1 1 0 0 1 1 1 0 BUD22 CCDC106 PF15794.5 CDI73781.1 - 1.2 8.8 21.0 1.2 8.8 21.0 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Nop53 PF07767.11 CDI73781.1 - 2.2 7.6 36.3 2.3 7.5 36.3 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) GEN1_C PF18380.1 CDI73781.1 - 4.4 8.3 23.9 5.2 8.0 23.9 1.2 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain Drc1-Sld2 PF11719.8 CDI73781.1 - 5.5 6.4 29.7 5.6 6.4 29.7 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein eIF3_subunit PF08597.10 CDI73781.1 - 6 6.7 40.6 6.2 6.7 40.6 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit CDC45 PF02724.14 CDI73781.1 - 6 5.0 32.7 6 5.0 32.7 1.0 1 0 0 1 1 1 0 CDC45-like protein PGA2 PF07543.12 CDI73781.1 - 7.7 6.5 25.5 10 6.1 25.5 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 Herpes_US9 PF06072.11 CDI73782.1 - 0.75 9.7 2.7 0.42 10.5 0.1 2.1 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 Tmemb_cc2 PF10267.9 CDI73784.1 - 0.12 11.5 0.1 0.14 11.2 0.1 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF4834 PF16118.5 CDI73786.1 - 0.044 14.7 1.2 0.044 14.7 1.2 4.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) EF-hand_4 PF12763.7 CDI73789.1 - 0.023 14.7 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Spt20 PF12090.8 CDI73789.1 - 0.051 13.2 3.6 0.063 12.9 3.6 1.1 1 0 0 1 1 1 0 Spt20 family Afi1 PF07792.12 CDI73790.1 - 0.0019 18.7 18.6 0.03 14.8 1.5 2.4 2 1 0 2 2 2 2 Docking domain of Afi1 for Arf3 in vesicle trafficking Ldh_1_N PF00056.23 CDI73790.1 - 0.93 9.6 5.2 0.9 9.6 0.3 2.2 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain DUF572 PF04502.13 CDI73790.1 - 0.97 9.0 19.6 1.3 8.6 19.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) LAP1C PF05609.12 CDI73790.1 - 1.8 7.5 25.0 2.6 7.0 25.0 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF4366 PF14283.6 CDI73790.1 - 5.1 7.1 17.2 0.16 12.0 1.6 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) zf-A20 PF01754.16 CDI73791.1 - 1.5e-23 82.3 22.7 1.5e-11 44.0 7.3 2.5 2 0 0 2 2 2 2 A20-like zinc finger DUF5402 PF17393.2 CDI73791.1 - 0.05 13.5 0.9 12 5.9 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5402) NMD3 PF04981.13 CDI73791.1 - 0.057 12.9 2.1 5.4 6.4 0.2 2.2 2 0 0 2 2 2 0 NMD3 family ORC5_C PF14630.6 CDI73791.1 - 0.91 9.0 16.2 0.46 9.9 1.3 2.6 3 0 0 3 3 3 0 Origin recognition complex (ORC) subunit 5 C-terminus Com_YlbF PF06133.11 CDI73791.1 - 1.1 9.9 9.0 6.1 7.5 1.8 2.3 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA PUB PF09409.10 CDI73793.1 - 8.9e-25 86.4 0.0 1.7e-24 85.5 0.0 1.5 1 0 0 1 1 1 1 PUB domain MCM3AP_GANP PF16769.5 CDI73793.1 - 0.037 12.3 8.2 0.039 12.2 8.2 1.2 1 0 0 1 1 1 0 MCM3AP domain of GANP DUF5401 PF17380.2 CDI73793.1 - 0.13 10.3 22.6 0.17 10.0 22.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) MAJIN PF15077.6 CDI73793.1 - 0.29 10.9 7.6 0.42 10.4 7.6 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein Exonuc_VII_L PF02601.15 CDI73793.1 - 1 8.8 8.7 1.2 8.6 8.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Erp_C PF06780.11 CDI73793.1 - 1.1 9.3 6.7 1.1 9.2 5.7 1.5 1 1 0 1 1 1 0 Erp protein C-terminus V_ATPase_I PF01496.19 CDI73793.1 - 1.5 6.6 7.4 1.6 6.5 7.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 CDI73793.1 - 5.9 6.1 10.4 8 5.7 10.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2785 PF10978.8 CDI73793.1 - 6.4 6.5 8.5 13 5.5 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2785) Nha1_C PF08619.10 CDI73794.1 - 0.14 11.3 2.8 0.2 10.8 2.8 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus SRRM_C PF15230.6 CDI73794.1 - 0.35 11.5 7.6 1 10.0 7.6 1.7 1 0 0 1 1 1 0 Serine/arginine repetitive matrix protein C-terminus APG6_N PF17675.1 CDI73795.1 - 2.6e-09 37.7 2.9 2.6e-09 37.7 2.9 1.8 2 1 0 2 2 2 1 Apg6 coiled-coil region Lectin_N PF03954.14 CDI73795.1 - 0.081 12.7 0.2 0.23 11.2 0.2 1.7 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF724 PF05266.14 CDI73795.1 - 0.084 12.7 2.3 0.22 11.3 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Methyltransf_32 PF13679.6 CDI73795.1 - 0.16 12.0 0.5 0.36 10.8 0.4 1.6 2 0 0 2 2 2 0 Methyltransferase domain tRNA_bind_2 PF13725.6 CDI73795.1 - 0.48 10.1 5.8 0.1 12.3 2.6 1.4 2 0 0 2 2 2 0 Possible tRNA binding domain Siah-Interact_N PF09032.11 CDI73795.1 - 0.55 10.6 4.4 0.35 11.2 1.8 2.1 2 0 0 2 2 2 0 Siah interacting protein, N terminal Macoilin PF09726.9 CDI73795.1 - 0.62 8.5 7.5 1.1 7.8 7.5 1.3 1 0 0 1 1 1 0 Macoilin family APG6 PF04111.12 CDI73796.1 - 1.3e-14 54.6 0.0 1.4e-14 54.5 0.0 1.0 1 0 0 1 1 1 1 Apg6 BARA domain SUIM_assoc PF16619.5 CDI73797.1 - 0.059 13.4 6.4 0.19 11.8 0.0 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Metallophos PF00149.28 CDI73798.1 - 3.5e-06 27.7 0.3 8.2e-05 23.2 0.0 2.5 3 0 0 3 3 3 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDI73798.1 - 0.0013 19.0 0.3 1.7 8.8 0.0 3.1 3 0 0 3 3 3 2 Calcineurin-like phosphoesterase superfamily domain 2TM PF13239.6 CDI73799.1 - 0.25 11.7 0.1 0.25 11.7 0.1 3.9 3 2 1 4 4 4 0 2TM domain RILP PF11461.8 CDI73800.1 - 1.4e-05 25.2 4.1 0.16 12.2 0.1 3.6 3 0 0 3 3 3 2 Rab interacting lysosomal protein KASH_CCD PF14662.6 CDI73800.1 - 0.008 16.0 10.8 0.008 16.0 10.8 5.2 4 2 1 5 5 5 2 Coiled-coil region of CCDC155 or KASH Uds1 PF15456.6 CDI73800.1 - 0.051 13.7 0.3 0.051 13.7 0.3 5.2 4 1 0 5 5 5 0 Up-regulated During Septation NPV_P10 PF05531.12 CDI73800.1 - 0.23 11.9 7.0 8.7 6.9 0.1 4.8 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein TSC22 PF01166.18 CDI73800.1 - 4.4 7.7 19.6 27 5.2 0.2 5.9 6 0 0 6 6 6 0 TSC-22/dip/bun family HALZ PF02183.18 CDI73800.1 - 6.2 7.1 31.4 2.5 8.4 3.1 6.1 5 1 1 6 6 6 0 Homeobox associated leucine zipper RPW8 PF05659.11 CDI73800.1 - 6.5 6.5 10.5 0.39 10.4 0.6 3.5 3 1 1 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 FapA PF03961.13 CDI73800.1 - 8.1 4.9 28.0 0.43 9.1 2.2 3.5 1 1 1 3 3 3 0 Flagellar Assembly Protein A RskA PF10099.9 CDI73802.1 - 0.015 15.6 19.3 0.015 15.6 19.3 8.1 2 2 4 6 6 6 0 Anti-sigma-K factor rskA N6_N4_Mtase PF01555.18 CDI73802.1 - 0.034 13.8 0.1 6.7 6.4 0.0 3.1 2 2 1 3 3 3 0 DNA methylase DUF4131 PF13567.6 CDI73804.1 - 0.1 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) SR-25 PF10500.9 CDI73805.1 - 3.4e-05 23.6 15.1 3.4e-05 23.6 15.1 2.3 1 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein DUF2207 PF09972.9 CDI73805.1 - 0.0043 15.9 3.1 0.055 12.2 0.0 2.1 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) DUF4366 PF14283.6 CDI73805.1 - 0.0065 16.5 2.0 0.0065 16.5 2.0 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4366) DUF4131 PF13567.6 CDI73805.1 - 0.023 14.4 1.2 0.023 14.4 1.2 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) N6_N4_Mtase PF01555.18 CDI73805.1 - 0.041 13.6 0.0 0.11 12.1 0.0 1.8 1 1 0 1 1 1 0 DNA methylase Utp14 PF04615.13 CDI73805.1 - 0.054 12.1 23.2 0.062 11.9 23.2 1.1 1 0 0 1 1 1 0 Utp14 protein SARAF PF06682.12 CDI73805.1 - 0.072 12.7 22.2 2.7 7.5 18.7 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Peptidase_S64 PF08192.11 CDI73805.1 - 0.097 11.2 22.3 0.13 10.7 22.3 1.2 1 0 0 1 1 1 0 Peptidase family S64 RskA PF10099.9 CDI73805.1 - 0.11 12.7 36.5 0.69 10.2 13.1 3.7 1 1 3 4 4 4 0 Anti-sigma-K factor rskA Cwf_Cwc_15 PF04889.12 CDI73805.1 - 0.14 11.9 29.0 0.18 11.5 29.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF4271 PF14093.6 CDI73805.1 - 0.17 11.8 1.6 0.2 11.6 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) GREB1 PF15782.5 CDI73805.1 - 0.28 8.3 30.3 0.35 7.9 30.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF1345 PF07077.11 CDI73805.1 - 0.48 10.1 8.7 1.1 9.0 0.1 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1345) DUF92 PF01940.16 CDI73805.1 - 0.53 9.7 3.6 11 5.4 0.9 2.2 1 1 0 2 2 2 0 Integral membrane protein DUF92 KASH PF10541.9 CDI73805.1 - 1.2 9.4 8.4 2.2 8.6 1.7 3.3 3 0 0 3 3 3 0 Nuclear envelope localisation domain PIG-S PF10510.9 CDI73805.1 - 1.4 7.7 28.8 1.6 7.4 28.8 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein CitMHS_2 PF16980.5 CDI73805.1 - 2.1 6.9 3.3 16 4.0 0.1 2.1 2 0 0 2 2 2 0 Putative citrate transport DUF979 PF06166.12 CDI73805.1 - 2.1 7.4 6.9 8.3 5.5 1.4 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF979) DUF2339 PF10101.9 CDI73805.1 - 2.3 6.7 8.8 4.5 5.7 8.8 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2339) Plant_vir_prot PF01307.17 CDI73805.1 - 2.9 8.2 7.0 20 5.5 0.5 3.3 2 1 1 3 3 3 0 Plant viral movement protein DUF819 PF05684.12 CDI73805.1 - 3.4 6.6 9.0 3.9 6.4 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF819) RAP1 PF07218.11 CDI73805.1 - 3.8 5.7 5.3 4.6 5.4 5.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DcuA_DcuB PF03605.14 CDI73805.1 - 3.9 6.3 11.7 1.8 7.4 0.6 2.2 1 1 1 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter TAF1D PF15333.6 CDI73805.1 - 5.5 6.7 20.7 3.6 7.2 7.7 2.2 2 0 0 2 2 2 0 TATA box-binding protein-associated factor 1D Velvet PF11754.8 CDI73805.1 - 8.3 6.3 40.5 0.41 10.5 14.5 2.0 1 1 1 2 2 2 0 Velvet factor CrgA PF06781.12 CDI73805.1 - 9 6.4 11.9 15 5.7 1.3 3.4 2 1 0 2 2 2 0 Cell division protein CrgA PIG-U PF06728.13 CDI73805.1 - 9.7 5.1 12.6 1.1e+02 1.6 11.4 2.3 1 1 0 1 1 1 0 GPI transamidase subunit PIG-U p25-alpha PF05517.12 CDI73807.1 - 1.2e-36 126.3 3.4 1.3e-36 126.1 3.4 1.0 1 0 0 1 1 1 1 p25-alpha Toprim_C_rpt PF13368.6 CDI73807.1 - 0.092 12.8 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Topoisomerase C-terminal repeat SET PF00856.28 CDI73808.1 - 6.4e-11 42.9 0.0 1.7e-09 38.3 0.0 2.5 1 1 0 1 1 1 1 SET domain RskA PF10099.9 CDI73808.1 - 4.1 7.7 18.4 1.1 9.5 0.3 3.5 3 0 0 3 3 3 0 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI73809.1 - 0.00054 19.6 7.5 0.00054 19.6 7.5 9.7 5 3 3 8 8 8 1 Nuclear RNA-splicing-associated protein CPSF73-100_C PF11718.8 CDI73809.1 - 0.0011 18.6 13.4 0.0011 18.6 13.4 7.7 5 3 1 6 6 6 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term RskA PF10099.9 CDI73809.1 - 0.0012 19.2 0.1 0.0012 19.2 0.1 8.7 2 2 4 6 6 6 1 Anti-sigma-K factor rskA NAM-associated PF14303.6 CDI73809.1 - 0.014 16.1 7.0 0.014 16.1 7.0 7.5 4 2 2 6 6 6 0 No apical meristem-associated C-terminal domain Caldesmon PF02029.15 CDI73810.1 - 0.012 14.4 60.6 0.0096 14.7 14.5 3.0 3 0 0 3 3 3 0 Caldesmon Mak16 PF04874.14 CDI73811.1 - 0.0021 18.6 3.8 0.0021 18.6 3.8 3.1 3 1 0 3 3 3 1 Mak16 protein C-terminal region CobT PF06213.12 CDI73811.1 - 0.004 16.6 11.0 0.004 16.6 11.0 3.2 2 1 0 2 2 1 1 Cobalamin biosynthesis protein CobT CLN3 PF02487.17 CDI73811.1 - 0.0065 15.6 6.4 0.0065 15.6 6.4 2.5 2 1 0 2 2 1 1 CLN3 protein Apt1 PF10351.9 CDI73811.1 - 0.0084 15.0 26.9 0.0073 15.2 16.1 2.1 2 0 0 2 2 2 2 Golgi-body localisation protein domain UPF0239 PF06783.11 CDI73811.1 - 0.05 13.8 1.1 0.05 13.8 1.1 3.2 2 1 0 3 3 3 0 Uncharacterised protein family (UPF0239) SDA1 PF05285.12 CDI73811.1 - 0.85 9.0 29.8 0.011 15.1 9.6 2.1 2 0 0 2 2 2 0 SDA1 SPX PF03105.19 CDI73811.1 - 1.4 8.7 36.9 1.1 9.2 24.3 2.1 2 0 0 2 2 2 0 SPX domain DUF2052 PF09747.9 CDI73811.1 - 1.5 8.9 28.4 0.23 11.6 6.9 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Pkinase_fungal PF17667.1 CDI73811.1 - 3.9 6.1 16.0 3.2 6.4 6.3 2.2 2 0 0 2 2 2 0 Fungal protein kinase SOG2 PF10428.9 CDI73811.1 - 7.2 5.7 34.3 0.029 13.6 17.9 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein SURF6 PF04935.12 CDI73811.1 - 8.4 6.1 46.1 0.17 11.6 16.4 2.2 2 0 0 2 2 2 0 Surfeit locus protein 6 DUF2052 PF09747.9 CDI73813.1 - 0.49 10.5 33.7 0.56 10.3 33.7 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Ribosomal_60s PF00428.19 CDI73813.1 - 0.68 10.6 6.4 1.1 9.9 6.4 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein RR_TM4-6 PF06459.12 CDI73813.1 - 0.83 9.4 33.8 0.91 9.3 33.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nop14 PF04147.12 CDI73813.1 - 0.97 7.6 26.3 1 7.5 26.3 1.0 1 0 0 1 1 1 0 Nop14-like family MCM_bind PF09739.9 CDI73813.1 - 7.9 4.8 26.7 8.6 4.7 26.7 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Endostatin PF06482.11 CDI73813.1 - 9.9 5.5 26.3 11 5.4 26.3 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF3458_C PF17432.2 CDI73815.1 - 1.1e-91 307.6 1.7 1.5e-91 307.1 1.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 CDI73815.1 - 2.3e-46 158.1 0.1 4.7e-46 157.1 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3458 PF11940.8 CDI73815.1 - 3e-18 66.0 0.0 7.1e-18 64.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1_N PF17900.1 CDI73815.1 - 1.8e-10 41.3 0.0 3.2e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M61 PF05299.12 CDI73815.1 - 0.00059 20.2 1.2 0.012 15.9 1.2 2.5 1 1 0 1 1 1 1 M61 glycyl aminopeptidase CDC48_2 PF02933.17 CDI73816.1 - 0.065 13.0 0.2 3 7.7 0.1 2.3 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 FAM176 PF14851.6 CDI73816.1 - 8.2 6.1 6.9 5.8 6.6 1.8 2.1 2 0 0 2 2 2 0 FAM176 family Methyltr_RsmB-F PF01189.17 CDI73817.1 - 2.3e-27 96.0 0.0 1.3e-25 90.2 0.0 3.2 2 1 0 2 2 2 1 16S rRNA methyltransferase RsmB/F SNF2_N PF00176.23 CDI73818.1 - 1.9e-40 138.6 0.1 3.5e-40 137.8 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDI73818.1 - 1.4e-12 48.0 0.0 4.2e-12 46.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI73818.1 - 5.5e-05 23.2 0.0 0.00014 21.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_14 PF13173.6 CDI73818.1 - 0.0044 17.1 0.0 0.013 15.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain SET PF00856.28 CDI73820.1 - 2.7e-12 47.4 3.0 1e-10 42.3 0.0 3.6 3 0 0 3 3 3 1 SET domain RapA_C PF12137.8 CDI73820.1 - 0.062 12.3 8.6 0.12 11.4 8.6 1.3 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal Arm PF00514.23 CDI73821.1 - 1.6e-08 34.3 5.0 0.053 13.6 0.0 5.6 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat V-ATPase_H_C PF11698.8 CDI73821.1 - 5.3e-06 26.5 0.0 5e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 V-ATPase subunit H HEAT_2 PF13646.6 CDI73821.1 - 6.3e-05 23.3 0.1 0.02 15.3 0.0 3.7 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.22 CDI73821.1 - 0.049 13.9 6.2 30 5.2 0.0 5.2 5 0 0 5 5 5 0 HEAT repeat Tim17 PF02466.19 CDI73823.1 - 5.8e-23 81.4 7.0 8.8e-23 80.8 7.0 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family UPF0060 PF02694.15 CDI73823.1 - 0.1 12.8 0.8 0.15 12.3 0.1 1.6 2 0 0 2 2 2 0 Uncharacterised BCR, YnfA/UPF0060 family DUF3128 PF11326.8 CDI73825.1 - 0.056 13.8 1.0 0.13 12.6 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3128) RALF PF05498.11 CDI73825.1 - 0.068 14.2 0.1 0.15 13.0 0.1 1.5 1 0 0 1 1 1 0 Rapid ALkalinization Factor (RALF) DUF3295 PF11702.8 CDI73827.1 - 0.45 9.8 25.6 0.6 9.4 25.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) SAPS PF04499.15 CDI73827.1 - 0.47 9.2 24.6 0.55 9.0 24.6 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NPR3 PF03666.13 CDI73827.1 - 0.9 8.3 29.5 1.1 8.0 29.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ALMT PF11744.8 CDI73827.1 - 2.1 7.1 30.3 2.6 6.8 30.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2052 PF09747.9 CDI73827.1 - 2.3 8.3 31.8 3 7.9 31.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) AF-4 PF05110.13 CDI73827.1 - 3.1 5.8 42.9 4.1 5.4 42.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Macoilin PF09726.9 CDI73827.1 - 3.5 6.1 30.5 5.2 5.5 30.5 1.2 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 CDI73827.1 - 3.6 6.2 41.8 4.4 6.0 41.8 1.0 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI73827.1 - 3.9 6.4 36.6 4.6 6.1 36.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 MCM_bind PF09739.9 CDI73827.1 - 5.7 5.3 29.5 6.6 5.1 29.5 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor RR_TM4-6 PF06459.12 CDI73827.1 - 6.7 6.5 34.5 8.3 6.1 34.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4569 PF15133.6 CDI73827.1 - 8.6 6.0 34.2 11 5.6 34.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) RskA PF10099.9 CDI73828.1 - 6.7e-06 26.5 0.3 6.7e-06 26.5 0.3 11.3 4 3 6 10 10 10 2 Anti-sigma-K factor rskA Apt1 PF10351.9 CDI73828.1 - 1.8e-05 23.8 0.0 1.8e-05 23.8 0.0 6.7 2 2 1 4 4 4 1 Golgi-body localisation protein domain AAA PF00004.29 CDI73828.1 - 0.029 14.8 0.9 0.66 10.4 0.0 3.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDI73828.1 - 0.044 13.8 0.0 0.14 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF3408 PF11888.8 CDI73830.1 - 0.27 11.4 19.2 0.3 11.2 19.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF5327 PF17261.2 CDI73830.1 - 0.27 12.0 23.6 0.34 11.7 23.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5327) DDRGK PF09756.9 CDI73830.1 - 0.39 10.3 23.1 0.41 10.2 23.1 1.1 1 0 0 1 1 1 0 DDRGK domain CobT PF06213.12 CDI73830.1 - 0.63 9.4 26.4 0.68 9.3 26.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3381 PF11861.8 CDI73830.1 - 0.63 9.8 18.1 0.74 9.6 18.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF1764 PF08576.10 CDI73830.1 - 0.63 11.0 14.6 0.67 10.9 14.6 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) HA2 PF04408.23 CDI73830.1 - 0.66 10.3 9.5 0.85 9.9 9.5 1.2 1 0 0 1 1 1 0 Helicase associated domain (HA2) MID_MedPIWI PF18296.1 CDI73830.1 - 0.71 9.6 16.5 0.79 9.5 16.5 1.0 1 0 0 1 1 1 0 MID domain of medPIWI Pex14_N PF04695.13 CDI73830.1 - 0.74 10.5 31.8 0.92 10.1 31.8 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Peptidase_U57 PF05582.12 CDI73830.1 - 0.79 8.9 13.7 0.85 8.8 13.7 1.0 1 0 0 1 1 1 0 YabG peptidase U57 F-protein PF00469.20 CDI73830.1 - 0.88 9.1 17.8 0.97 9.0 17.8 1.0 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef TFIIA PF03153.13 CDI73830.1 - 0.88 9.5 46.3 0.92 9.4 46.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Afi1 PF07792.12 CDI73830.1 - 1.2 9.6 15.7 1.3 9.5 15.7 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking AIF_C PF14721.6 CDI73830.1 - 1.2 9.4 14.6 1.4 9.3 14.6 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4746 PF15928.5 CDI73830.1 - 1.6 8.1 15.2 1.6 8.1 15.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SpoIIP PF07454.11 CDI73830.1 - 1.6 8.1 21.1 1.7 8.0 21.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FYDLN_acid PF09538.10 CDI73830.1 - 1.7 9.4 12.4 2.1 9.1 12.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Eapp_C PF10238.9 CDI73830.1 - 2 8.5 18.8 2.4 8.2 18.8 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein Paf1 PF03985.13 CDI73830.1 - 2.2 7.2 21.7 2.3 7.1 21.7 1.0 1 0 0 1 1 1 0 Paf1 DUF4770 PF15994.5 CDI73830.1 - 2.4 8.3 19.3 3 8.0 19.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) XRN_M PF17846.1 CDI73830.1 - 2.5 6.9 13.3 2.6 6.9 13.3 1.0 1 0 0 1 1 1 0 Xrn1 helical domain FAM176 PF14851.6 CDI73830.1 - 2.6 7.7 11.9 3 7.5 11.9 1.2 1 0 0 1 1 1 0 FAM176 family GNAT_acetyltr_2 PF13718.6 CDI73830.1 - 2.6 7.4 12.0 2.9 7.2 12.0 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 FAM60A PF15396.6 CDI73830.1 - 2.7 7.9 15.7 3.2 7.7 15.7 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Tim54 PF11711.8 CDI73830.1 - 2.9 6.6 18.0 3.1 6.5 18.0 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CPSF100_C PF13299.6 CDI73830.1 - 2.9 8.0 16.8 3.3 7.9 16.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal TERB2 PF15101.6 CDI73830.1 - 3.1 7.8 25.8 3.3 7.7 25.8 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Connexin PF00029.19 CDI73830.1 - 3.3 7.4 15.5 3.3 7.4 15.5 1.1 1 0 0 1 1 1 0 Connexin DUF3464 PF11947.8 CDI73830.1 - 3.4 7.4 19.9 4 7.2 19.9 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 PIP5K PF01504.18 CDI73830.1 - 3.6 6.7 16.3 4 6.6 16.3 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Presenilin PF01080.17 CDI73830.1 - 4.1 6.1 24.8 4.6 5.9 24.8 1.0 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI73830.1 - 4.2 6.3 18.5 4.3 6.2 18.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DDHD PF02862.17 CDI73830.1 - 4.2 7.5 18.7 4.6 7.3 18.7 1.1 1 0 0 1 1 1 0 DDHD domain DUF4228 PF14009.6 CDI73830.1 - 4.2 7.7 13.2 4.6 7.6 13.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) V_ATPase_I PF01496.19 CDI73830.1 - 4.5 5.1 21.0 4.9 5.0 21.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-3_zeta PF05091.12 CDI73830.1 - 4.5 6.1 27.2 5 6.0 27.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rxt3 PF08642.10 CDI73830.1 - 4.6 8.0 10.5 6.2 7.6 10.5 1.4 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Peroxin-13_N PF04088.13 CDI73830.1 - 5 7.4 10.9 5.5 7.2 10.9 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Serinc PF03348.15 CDI73830.1 - 5 5.9 15.9 5.2 5.9 15.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Band_3_cyto PF07565.13 CDI73830.1 - 5 6.8 20.4 5.5 6.7 20.4 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Endostatin PF06482.11 CDI73830.1 - 5.2 6.4 19.6 6.2 6.2 19.6 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Baculo_PP31 PF05311.11 CDI73830.1 - 5.2 6.5 18.7 5.5 6.4 18.7 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) CSG2 PF16965.5 CDI73830.1 - 5.6 5.8 12.0 6.1 5.7 12.0 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator RR_TM4-6 PF06459.12 CDI73830.1 - 5.7 6.7 20.6 6.2 6.6 20.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.8 CDI73830.1 - 5.7 5.7 20.8 6.2 5.6 20.8 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Gti1_Pac2 PF09729.9 CDI73830.1 - 5.8 7.0 16.3 6.4 6.8 16.3 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF3371 PF11851.8 CDI73830.1 - 6 8.0 20.5 8.8 7.4 20.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) DUF4638 PF15472.6 CDI73830.1 - 6.5 6.4 15.4 6.2 6.5 15.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) G0-G1_switch_2 PF15103.6 CDI73830.1 - 6.9 7.2 14.7 9.1 6.8 14.7 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 PPL5 PF18168.1 CDI73830.1 - 7.3 5.8 15.5 7.8 5.7 15.5 1.0 1 0 0 1 1 1 0 Prim-pol family 5 PEX11 PF05648.14 CDI73830.1 - 7.3 6.0 11.0 8.5 5.8 11.0 1.1 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Cellulose_synt PF03552.14 CDI73830.1 - 7.5 4.9 8.5 7.8 4.9 8.5 1.0 1 0 0 1 1 1 0 Cellulose synthase MecA PF05389.12 CDI73830.1 - 7.6 6.1 16.2 8.8 5.9 16.2 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) TFB6 PF17110.5 CDI73830.1 - 7.6 6.2 13.0 8.6 6.1 13.0 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Pal1 PF08316.11 CDI73830.1 - 8.3 7.2 10.3 9.6 7.0 10.3 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein DUF2828 PF11443.8 CDI73830.1 - 8.9 4.3 19.6 9.9 4.1 19.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Velvet PF11754.8 CDI73830.1 - 8.9 6.2 21.1 9.5 6.1 21.1 1.0 1 0 0 1 1 1 0 Velvet factor CDC45 PF02724.14 CDI73830.1 - 9.1 4.4 17.1 9.4 4.4 17.1 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4175 PF13779.6 CDI73830.1 - 9.7 3.9 40.2 9.6 4.0 40.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) YABBY PF04690.13 CDI73830.1 - 9.8 6.7 16.4 11 6.5 16.4 1.1 1 0 0 1 1 1 0 YABBY protein ALMT PF11744.8 CDI73830.1 - 9.9 4.9 14.9 9.8 4.9 14.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter OATP PF03137.20 CDI73830.1 - 10 4.3 12.2 11 4.1 12.2 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family FAM199X PF15814.5 CDI73831.1 - 0.028 13.5 17.5 0.032 13.3 17.5 1.0 1 0 0 1 1 1 0 Protein family FAM199X Trp_oprn_chp PF09534.10 CDI73831.1 - 0.08 12.7 24.6 0.095 12.5 24.6 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF726 PF05277.12 CDI73831.1 - 0.37 9.7 11.3 0.41 9.5 11.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Tic110 PF16940.5 CDI73831.1 - 0.45 9.0 15.4 0.51 8.8 15.4 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter Peptidase_M56 PF05569.11 CDI73831.1 - 0.47 9.6 7.4 0.52 9.5 7.4 1.0 1 0 0 1 1 1 0 BlaR1 peptidase M56 SR-25 PF10500.9 CDI73831.1 - 0.57 9.8 11.8 1.2 8.7 11.8 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med3 PF11593.8 CDI73831.1 - 4.4 6.4 40.5 5.2 6.1 40.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Hamartin PF04388.12 CDI73831.1 - 5.1 5.6 12.3 5.6 5.5 12.3 1.0 1 0 0 1 1 1 0 Hamartin protein TFIIA PF03153.13 CDI73831.1 - 5.6 6.9 23.1 6.4 6.7 23.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SDA1 PF05285.12 CDI73832.1 - 0.14 11.6 50.5 0.17 11.3 50.5 1.1 1 0 0 1 1 1 0 SDA1 Macoilin PF09726.9 CDI73832.1 - 1.8 7.0 50.5 2.1 6.8 50.5 1.0 1 0 0 1 1 1 0 Macoilin family AAA_15 PF13175.6 CDI73832.1 - 5 6.7 32.9 5.7 6.5 32.9 1.0 1 0 0 1 1 1 0 AAA ATPase domain Trypan_PARP PF05887.11 CDI73832.1 - 6.6 6.7 16.2 9.4 6.2 16.2 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CCDC53 PF10152.9 CDI73833.1 - 0.063 13.7 25.3 0.076 13.4 25.3 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex SpoIIP PF07454.11 CDI73833.1 - 0.099 12.1 29.0 0.11 11.9 29.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) MID_MedPIWI PF18296.1 CDI73833.1 - 0.17 11.7 17.3 0.19 11.5 17.3 1.0 1 0 0 1 1 1 0 MID domain of medPIWI Pex14_N PF04695.13 CDI73833.1 - 0.37 11.5 25.7 0.45 11.2 25.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CobT PF06213.12 CDI73833.1 - 0.54 9.6 32.4 0.65 9.3 32.4 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT eIF-3_zeta PF05091.12 CDI73833.1 - 0.64 8.9 31.3 0.7 8.8 31.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PRP1_N PF06424.12 CDI73833.1 - 0.68 10.3 25.4 0.8 10.1 25.4 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal RNA_pol_Rpc4 PF05132.14 CDI73833.1 - 0.69 10.3 22.9 0.97 9.9 22.9 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Band_3_cyto PF07565.13 CDI73833.1 - 0.77 9.5 19.3 0.88 9.3 19.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2072 PF09845.9 CDI73833.1 - 0.85 9.9 19.2 1.1 9.6 19.2 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein TFIIA PF03153.13 CDI73833.1 - 1.1 9.1 44.3 1.2 9.1 44.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Myc_N PF01056.18 CDI73833.1 - 1.1 9.1 17.5 1.3 8.9 17.5 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Vfa1 PF08432.10 CDI73833.1 - 1.2 9.4 31.2 1.4 9.2 31.2 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF5308 PF17233.2 CDI73833.1 - 1.2 9.3 17.4 1.6 9.0 17.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Baculo_PP31 PF05311.11 CDI73833.1 - 1.3 8.4 22.5 1.7 8.0 22.5 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Connexin PF00029.19 CDI73833.1 - 1.4 8.6 21.4 1.6 8.4 21.4 1.2 1 0 0 1 1 1 0 Connexin Peptidase_U57 PF05582.12 CDI73833.1 - 2.3 7.4 17.1 2.6 7.2 17.1 1.2 1 0 0 1 1 1 0 YabG peptidase U57 TCRP1 PF14944.6 CDI73833.1 - 2.4 8.1 5.4 2.8 7.9 5.4 1.0 1 0 0 1 1 1 0 Tongue Cancer Chemotherapy Resistant Protein 1 DDHD PF02862.17 CDI73833.1 - 2.7 8.1 21.7 3.3 7.8 21.7 1.2 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 CDI73833.1 - 2.9 7.6 31.3 3.3 7.5 31.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 CDI73833.1 - 3 6.7 17.3 3.4 6.5 17.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Rtf2 PF04641.12 CDI73833.1 - 3.1 7.1 27.2 3.3 7.0 27.2 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Gti1_Pac2 PF09729.9 CDI73833.1 - 3.3 7.8 22.2 3.9 7.5 22.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF2828 PF11443.8 CDI73833.1 - 3.5 5.6 26.0 3.8 5.5 26.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4746 PF15928.5 CDI73833.1 - 3.5 6.9 25.4 3.8 6.8 25.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Velvet PF11754.8 CDI73833.1 - 3.9 7.3 18.3 4.2 7.2 18.3 1.1 1 0 0 1 1 1 0 Velvet factor PPL5 PF18168.1 CDI73833.1 - 4 6.6 20.8 4.7 6.4 20.8 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Sec62 PF03839.16 CDI73833.1 - 4.8 6.6 24.9 5.5 6.4 24.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 BORG_CEP PF14957.6 CDI73833.1 - 4.9 8.3 18.2 6.1 8.0 18.2 1.2 1 0 0 1 1 1 0 Cdc42 effector Endostatin PF06482.11 CDI73833.1 - 5.1 6.5 21.0 5 6.5 21.0 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF3807 PF12720.7 CDI73833.1 - 5.3 7.3 37.4 5.9 7.1 37.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Membralin PF09746.9 CDI73833.1 - 5.4 5.9 16.8 5.5 5.9 16.8 1.0 1 0 0 1 1 1 0 Tumour-associated protein TraV PF09676.10 CDI73833.1 - 5.6 8.0 22.1 7.6 7.5 22.1 1.2 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) NARP1 PF12569.8 CDI73833.1 - 5.9 5.7 31.6 6.1 5.6 31.6 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 PAT1 PF09770.9 CDI73833.1 - 6.4 4.9 35.1 7.3 4.7 35.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 F-protein PF00469.20 CDI73833.1 - 6.6 6.3 20.3 7.5 6.1 20.3 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Tim54 PF11711.8 CDI73833.1 - 6.8 5.4 25.3 7.6 5.2 25.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Neur_chan_memb PF02932.16 CDI73833.1 - 7 6.6 22.6 7.5 6.5 22.6 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CAC1F_C PF16885.5 CDI73833.1 - 7.1 6.2 20.0 7.9 6.0 20.0 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Afi1 PF07792.12 CDI73833.1 - 7.1 7.1 25.2 9.6 6.7 25.2 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF966 PF06136.13 CDI73833.1 - 8 6.1 23.4 8.5 6.0 23.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) AAR2 PF05282.11 CDI73833.1 - 8.4 5.7 18.2 8.9 5.6 18.2 1.1 1 0 0 1 1 1 0 AAR2 protein Peptidase_S64 PF08192.11 CDI73833.1 - 8.7 4.7 21.7 8.9 4.7 21.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 ASC PF00858.24 CDI73833.1 - 9.1 5.1 13.1 9.4 5.1 13.1 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel SLC12 PF03522.15 CDI73833.1 - 9.2 5.2 28.3 9.9 5.1 28.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 CDI73833.1 - 9.8 4.8 33.5 10 4.8 33.5 1.0 1 0 0 1 1 1 0 Presenilin DREPP PF05558.12 CDI73834.1 - 3.9 7.3 12.1 4.2 7.2 12.1 1.0 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide DUF3499 PF12005.8 CDI73834.1 - 5.5 7.6 10.2 7.4 7.2 10.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3499) RskA PF10099.9 CDI73836.1 - 7.2e-05 23.2 8.0 0.00016 22.0 8.0 1.8 1 1 0 1 1 1 1 Anti-sigma-K factor rskA DUF4179 PF13786.6 CDI73836.1 - 0.033 14.7 0.1 0.072 13.6 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) PAD_M PF08527.10 CDI73836.1 - 0.11 12.2 6.7 0.14 11.8 6.7 1.3 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain CSG2 PF16965.5 CDI73836.1 - 0.12 11.3 2.1 0.12 11.3 2.1 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator LMBR1 PF04791.16 CDI73836.1 - 0.19 10.6 4.7 0.24 10.2 4.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Ctr PF04145.15 CDI73836.1 - 0.52 10.9 7.9 0.85 10.2 7.9 1.5 1 1 0 1 1 1 0 Ctr copper transporter family DUF4446 PF14584.6 CDI73836.1 - 0.88 9.6 9.1 0.77 9.7 2.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF1512 PF07431.12 CDI73836.1 - 1.1 8.2 10.2 0.058 12.4 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1512) DUF778 PF05608.12 CDI73836.1 - 1.1 9.5 9.4 1.5 9.2 9.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF778) DUF775 PF05603.12 CDI73836.1 - 1.5 8.3 13.2 0.052 13.1 6.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF775) DUF2722 PF10846.8 CDI73836.1 - 2.6 6.9 29.6 0.034 13.1 17.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF4140 PF13600.6 CDI73836.1 - 3.1 8.3 18.2 0.59 10.6 12.1 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) R_equi_Vir PF05526.11 CDI73836.1 - 4.4 7.1 8.5 0.62 9.9 4.5 1.6 2 0 0 2 2 2 0 Rhodococcus equi virulence-associated protein DUF4199 PF13858.6 CDI73836.1 - 6.8 7.1 6.8 0.37 11.2 1.7 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF4199) Spt20 PF12090.8 CDI73836.1 - 9.4 5.8 41.4 1.3 8.6 29.1 2.1 2 0 0 2 2 2 0 Spt20 family Androgen_recep PF02166.16 CDI73837.1 - 0.0026 16.7 6.5 0.0027 16.6 6.5 1.0 1 0 0 1 1 1 1 Androgen receptor DUF5421 PF17458.2 CDI73837.1 - 0.029 13.8 5.9 0.033 13.6 5.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5421) Spt20 PF12090.8 CDI73837.1 - 0.26 10.9 13.3 0.27 10.8 13.3 1.1 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 CDI73837.1 - 0.57 9.2 8.9 0.56 9.2 8.9 1.0 1 0 0 1 1 1 0 Drosophila roughex protein DUF3682 PF12446.8 CDI73837.1 - 2.3 8.7 19.2 2.9 8.4 19.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) UPF0560 PF10577.9 CDI73837.1 - 2.3 6.6 7.9 2.2 6.7 7.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 FAST_1 PF06743.15 CDI73838.1 - 0.3 11.1 2.7 2.7 8.0 0.4 2.7 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 Serinc PF03348.15 CDI73838.1 - 0.42 9.5 2.5 2.7 6.8 2.2 2.3 2 0 0 2 2 2 0 Serine incorporator (Serinc) Folate_carrier PF01770.18 CDI73838.1 - 1.2 7.8 5.7 7.5 5.2 1.8 2.5 2 0 0 2 2 2 0 Reduced folate carrier Connexin PF00029.19 CDI73838.1 - 6.3 6.5 6.1 1.5 8.5 2.3 1.9 2 0 0 2 2 2 0 Connexin IMUP PF15761.5 CDI73838.1 - 6.3 7.5 23.6 12 6.6 9.3 3.0 2 0 0 2 2 2 0 Immortalisation up-regulated protein Shadoo PF14999.6 CDI73839.1 - 0.37 10.9 13.1 0.4 10.8 11.8 1.9 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective TFIIA PF03153.13 CDI73839.1 - 1.4 8.9 19.5 1.9 8.4 19.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MDM10 PF12519.8 CDI73840.1 - 1.1 8.1 37.3 1.3 7.8 37.3 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Presenilin PF01080.17 CDI73840.1 - 4.2 6.0 51.2 5.6 5.6 51.2 1.1 1 0 0 1 1 1 0 Presenilin NAP PF00956.18 CDI73842.1 - 2e-16 60.0 3.9 1.1e-08 34.6 0.0 3.4 2 2 1 3 3 2 2 Nucleosome assembly protein (NAP) Cwf_Cwc_15 PF04889.12 CDI73842.1 - 0.003 17.3 5.5 0.003 17.3 5.5 2.2 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 CDI73842.1 - 0.017 13.5 12.9 0.023 13.0 12.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI73842.1 - 0.054 12.3 8.3 0.073 11.8 8.3 1.2 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 CDI73842.1 - 0.073 12.0 11.5 0.099 11.6 11.5 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EOS1 PF12326.8 CDI73842.1 - 0.25 11.3 0.6 0.26 11.2 0.6 1.3 1 0 0 1 1 1 0 N-glycosylation protein FAD-SLDH PF12318.8 CDI73842.1 - 0.28 11.2 7.8 1 9.4 6.8 2.2 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase Sigma70_ner PF04546.13 CDI73842.1 - 0.63 9.9 17.5 0.041 13.8 11.3 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region Hid1 PF12722.7 CDI73842.1 - 0.91 7.6 10.1 1.1 7.3 10.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM176 PF14851.6 CDI73842.1 - 3 7.5 13.5 3.2 7.4 3.0 2.5 2 0 0 2 2 2 0 FAM176 family GREB1 PF15782.5 CDI73842.1 - 3.8 4.5 12.6 5.1 4.1 12.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PigN PF04987.14 CDI73842.1 - 7.6 5.3 4.7 11 4.8 4.7 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Med15 PF09606.10 CDI73842.1 - 7.8 5.0 27.9 11 4.6 27.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RR_TM4-6 PF06459.12 CDI73843.1 - 0.0023 17.8 16.2 0.0028 17.5 16.2 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Pex14_N PF04695.13 CDI73843.1 - 0.0086 16.7 31.0 0.016 15.9 31.0 1.4 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Tim54 PF11711.8 CDI73843.1 - 0.0098 14.7 18.0 0.014 14.2 18.0 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 DUF913 PF06025.12 CDI73843.1 - 0.01 14.8 10.3 0.013 14.5 10.3 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DDHD PF02862.17 CDI73843.1 - 0.017 15.3 14.9 0.02 15.0 14.9 1.1 1 0 0 1 1 1 0 DDHD domain Endostatin PF06482.11 CDI73843.1 - 0.017 14.6 15.1 0.018 14.5 15.1 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin AIF_C PF14721.6 CDI73843.1 - 0.017 15.5 11.6 0.028 14.8 11.6 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Baculo_PP31 PF05311.11 CDI73843.1 - 0.02 14.4 13.3 0.023 14.2 13.3 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) TCP PF03634.13 CDI73843.1 - 0.033 14.8 16.5 0.039 14.5 16.5 1.1 1 0 0 1 1 1 0 TCP family transcription factor CPSF100_C PF13299.6 CDI73843.1 - 0.043 14.0 14.5 0.062 13.5 14.5 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal PAT1 PF09770.9 CDI73843.1 - 0.053 11.8 33.5 0.063 11.6 33.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AUX_IAA PF02309.16 CDI73843.1 - 0.063 13.1 7.2 0.078 12.8 7.2 1.2 1 0 0 1 1 1 0 AUX/IAA family DUF4746 PF15928.5 CDI73843.1 - 0.068 12.6 16.1 0.089 12.2 16.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SpoIIP PF07454.11 CDI73843.1 - 0.075 12.5 22.4 0.097 12.1 22.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Neur_chan_memb PF02932.16 CDI73843.1 - 0.1 12.6 13.0 0.12 12.4 13.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TFIIA PF03153.13 CDI73843.1 - 0.13 12.2 53.8 0.18 11.7 53.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Velvet PF11754.8 CDI73843.1 - 0.14 12.1 17.6 0.16 11.9 17.6 1.1 1 0 0 1 1 1 0 Velvet factor SID-1_RNA_chan PF13965.6 CDI73843.1 - 0.27 9.6 8.4 0.29 9.5 8.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Band_3_cyto PF07565.13 CDI73843.1 - 0.36 10.6 19.5 0.46 10.2 19.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RP-C_C PF11800.8 CDI73843.1 - 0.51 10.4 19.6 0.69 10.0 19.6 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region MCD PF05292.11 CDI73843.1 - 0.52 9.8 9.7 0.63 9.6 9.7 1.1 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain Connexin PF00029.19 CDI73843.1 - 0.53 10.0 16.9 0.63 9.7 16.9 1.1 1 0 0 1 1 1 0 Connexin CSG2 PF16965.5 CDI73843.1 - 0.63 8.9 11.6 0.74 8.7 11.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Zip PF02535.22 CDI73843.1 - 0.7 9.0 7.7 0.86 8.8 7.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Ureide_permease PF07168.11 CDI73843.1 - 0.86 8.3 8.2 1.1 7.9 8.2 1.1 1 0 0 1 1 1 0 Ureide permease FAM60A PF15396.6 CDI73843.1 - 0.99 9.4 16.7 1.2 9.1 16.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A ALMT PF11744.8 CDI73843.1 - 1.2 7.9 16.6 1.5 7.6 16.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter RPN2_C PF18004.1 CDI73843.1 - 1.2 9.0 21.5 1.7 8.5 21.5 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Serinc PF03348.15 CDI73843.1 - 1.2 8.0 13.2 1.5 7.7 13.2 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) FAM176 PF14851.6 CDI73843.1 - 1.3 8.7 13.5 1.9 8.1 13.5 1.2 1 0 0 1 1 1 0 FAM176 family BORG_CEP PF14957.6 CDI73843.1 - 1.6 9.9 14.3 2.6 9.2 14.3 1.3 1 0 0 1 1 1 0 Cdc42 effector Tam41_Mmp37 PF09139.11 CDI73843.1 - 1.6 8.1 16.8 2.1 7.7 16.8 1.1 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial DUF5308 PF17233.2 CDI73843.1 - 2.5 8.3 19.4 3.9 7.7 19.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5308) CobT PF06213.12 CDI73843.1 - 2.6 7.3 37.8 3.7 6.9 37.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Folate_carrier PF01770.18 CDI73843.1 - 2.9 6.5 11.7 3.8 6.1 11.7 1.1 1 0 0 1 1 1 0 Reduced folate carrier CBP_BcsG PF11658.8 CDI73843.1 - 3.3 6.0 18.6 3.8 5.8 18.6 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG UPF0565 PF10561.9 CDI73843.1 - 4.1 6.5 12.7 5 6.2 12.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 eIF-3_zeta PF05091.12 CDI73843.1 - 4.5 6.1 32.3 6 5.7 32.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Folliculin PF11704.8 CDI73843.1 - 5.4 6.9 20.7 7.1 6.5 20.7 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport YABBY PF04690.13 CDI73843.1 - 5.4 7.5 18.7 7.3 7.1 18.7 1.1 1 0 0 1 1 1 0 YABBY protein Hydin_ADK PF17213.3 CDI73843.1 - 5.9 7.1 16.5 9.8 6.4 16.5 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain V_ATPase_I PF01496.19 CDI73843.1 - 7.5 4.3 28.7 9 4.1 28.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S49_N PF08496.10 CDI73843.1 - 8 6.5 20.2 14 5.7 20.2 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MDM31_MDM32 PF08118.11 CDI73843.1 - 8.4 4.9 15.8 11 4.5 15.8 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins CCDC53 PF10152.9 CDI73843.1 - 8.6 6.8 29.1 20 5.6 29.1 1.5 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF2828 PF11443.8 CDI73843.1 - 9.4 4.2 24.9 11 3.9 24.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Roughex PF06020.11 CDI73844.1 - 0.02 14.0 8.9 0.02 14.0 8.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Band_3_cyto PF07565.13 CDI73844.1 - 0.028 14.2 10.1 0.031 14.1 10.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TT_ORF1 PF02956.14 CDI73844.1 - 0.051 12.3 6.0 0.054 12.2 6.0 1.1 1 0 0 1 1 1 0 TT viral orf 1 FAM176 PF14851.6 CDI73844.1 - 0.11 12.2 3.1 0.15 11.7 3.1 1.3 1 0 0 1 1 1 0 FAM176 family SLC12 PF03522.15 CDI73844.1 - 0.17 10.9 10.4 0.18 10.8 10.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Mcm10 PF09332.11 CDI73844.1 - 0.25 10.7 17.7 0.33 10.3 17.7 1.1 1 0 0 1 1 1 0 Mcm10 replication factor Eaf7 PF07904.13 CDI73844.1 - 0.28 11.6 9.2 0.48 10.8 9.2 1.3 1 0 0 1 1 1 0 Chromatin modification-related protein EAF7 BAF1_ABF1 PF04684.13 CDI73844.1 - 0.32 10.0 12.6 0.44 9.5 12.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Neur_chan_memb PF02932.16 CDI73844.1 - 0.36 10.8 7.9 0.41 10.7 7.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Membralin PF09746.9 CDI73844.1 - 0.46 9.5 4.9 0.44 9.5 4.9 1.1 1 0 0 1 1 1 0 Tumour-associated protein FAM60A PF15396.6 CDI73844.1 - 0.51 10.3 6.6 0.59 10.1 6.6 1.2 1 0 0 1 1 1 0 Protein Family FAM60A UPF0560 PF10577.9 CDI73844.1 - 0.97 7.9 20.7 1.2 7.6 20.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TFIIA PF03153.13 CDI73844.1 - 1.1 9.2 40.0 1.6 8.7 40.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AIF-MLS PF14962.6 CDI73844.1 - 1.3 8.9 12.2 1.7 8.6 12.2 1.0 1 0 0 1 1 1 0 Mitochondria Localisation Sequence ALMT PF11744.8 CDI73844.1 - 1.4 7.7 8.4 1.3 7.7 8.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 CDI73844.1 - 1.4 7.6 13.8 1.5 7.6 13.8 1.2 1 0 0 1 1 1 0 Presenilin PepSY_TM_like_2 PF16357.5 CDI73844.1 - 1.5 8.7 11.5 1.9 8.4 11.5 1.2 1 0 0 1 1 1 0 Putative PepSY_TM-like CCSAP PF15748.5 CDI73844.1 - 2.1 8.4 16.3 2.9 8.0 16.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF3984 PF13136.6 CDI73844.1 - 2.1 7.6 12.0 3.9 6.8 12.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) GREB1 PF15782.5 CDI73844.1 - 2.4 5.2 12.6 2.5 5.1 12.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2126 PF09899.9 CDI73844.1 - 2.5 6.1 10.5 2.9 5.8 10.5 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) MDM10 PF12519.8 CDI73844.1 - 3 6.6 9.3 2.9 6.6 9.3 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Connexin PF00029.19 CDI73844.1 - 3.3 7.4 8.7 4.7 6.9 8.7 1.2 1 0 0 1 1 1 0 Connexin Calici_coat_C PF08435.11 CDI73844.1 - 5.2 6.5 14.6 5.1 6.5 14.4 1.2 1 1 0 1 1 1 0 Calicivirus coat protein C-terminal CSG2 PF16965.5 CDI73844.1 - 6.2 5.7 7.5 8.3 5.2 7.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Serinc PF03348.15 CDI73844.1 - 7 5.5 7.9 9.6 5.0 7.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) PIP5K PF01504.18 CDI73844.1 - 7.7 5.7 12.5 11 5.1 12.5 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase SID-1_RNA_chan PF13965.6 CDI73844.1 - 7.8 4.8 6.5 10 4.4 6.5 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI73844.1 - 7.8 4.3 15.8 11 3.8 15.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S49_N PF08496.10 CDI73844.1 - 7.9 6.5 15.1 2.5 8.2 12.0 1.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal EOS1 PF12326.8 CDI73844.1 - 8.8 6.2 8.0 3.4 7.6 5.9 1.4 2 0 0 2 2 1 0 N-glycosylation protein DUF572 PF04502.13 CDI73844.1 - 9.4 5.7 21.2 10 5.6 21.2 1.2 1 1 0 1 1 1 0 Family of unknown function (DUF572) DUF4366 PF14283.6 CDI73845.1 - 0.00031 20.8 0.8 0.00031 20.8 0.8 2.9 2 1 1 3 3 3 1 Domain of unknown function (DUF4366) GREB1 PF15782.5 CDI73845.1 - 0.63 7.1 39.8 0.78 6.8 39.8 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MOZ_SAS PF01853.18 CDI73846.1 - 2.8e-74 248.7 0.0 3.7e-74 248.3 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CDI73846.1 - 1.9e-17 62.6 0.1 3.9e-17 61.6 0.1 1.5 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 CDI73846.1 - 5e-08 32.7 0.0 1e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 CDI73846.1 - 0.0028 18.0 0.0 0.0058 17.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PP2C PF00481.21 CDI73847.1 - 6.6e-37 127.5 0.0 3.3e-36 125.2 0.0 1.9 2 0 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 CDI73847.1 - 0.00093 19.2 0.0 0.052 13.5 0.0 2.8 3 0 0 3 3 3 1 Stage II sporulation protein E (SpoIIE) GAS PF13851.6 CDI73849.1 - 0.026 13.9 26.2 0.021 14.2 13.1 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Helo_like_N PF17111.5 CDI73849.1 - 0.31 10.4 13.5 0.021 14.2 7.1 2.1 1 1 0 2 2 2 0 Fungal N-terminal domain of STAND proteins GNT-I PF03071.15 CDI73849.1 - 0.68 8.6 5.2 0.32 9.7 2.5 1.8 1 1 1 2 2 2 0 GNT-I family Syntaxin-6_N PF09177.11 CDI73849.1 - 1.2 9.8 15.4 1.5e+03 -0.2 15.4 2.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal BLOC1_2 PF10046.9 CDI73849.1 - 1.6 9.1 12.6 1.2 9.5 1.3 3.1 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SOGA PF11365.8 CDI73849.1 - 1.7 9.9 22.7 17 6.6 18.3 3.2 1 1 2 3 3 3 0 Protein SOGA DUF4140 PF13600.6 CDI73849.1 - 3.3 8.2 14.0 2.6 8.5 0.3 3.5 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) FlaC_arch PF05377.11 CDI73849.1 - 4 7.9 11.4 53 4.3 2.2 4.8 2 1 4 6 6 6 0 Flagella accessory protein C (FlaC) Prefoldin PF02996.17 CDI73849.1 - 9.8 6.1 17.5 3.7 7.5 1.2 3.6 2 2 0 3 3 3 0 Prefoldin subunit E1-E2_ATPase PF00122.20 CDI73850.1 - 2e-46 157.8 0.2 2e-46 157.8 0.2 2.3 1 1 1 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CDI73850.1 - 3.1e-34 118.3 1.2 3.1e-33 115.0 0.0 2.7 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 CDI73850.1 - 4.5e-19 67.9 0.0 1.1e-18 66.7 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 CDI73850.1 - 3e-18 66.9 2.4 2.5e-16 60.6 2.4 3.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDI73850.1 - 6.2e-08 32.6 0.0 2.4e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CDI73850.1 - 0.0021 17.8 0.6 0.0039 16.9 0.3 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDI73850.1 - 0.0046 17.4 0.0 0.012 16.1 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF1685 PF07939.11 CDI73850.1 - 0.028 14.2 0.9 0.068 12.9 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1685) SpoIIM PF01944.17 CDI73850.1 - 1.1 9.3 0.0 1.1 9.3 0.0 4.0 4 0 0 4 4 4 0 Stage II sporulation protein M SART-1 PF03343.13 CDI73852.1 - 0.00019 20.2 9.9 0.00019 20.2 9.9 8.9 6 3 2 8 8 8 1 SART-1 family RskA PF10099.9 CDI73852.1 - 0.0053 17.1 3.6 0.0053 17.1 3.6 24.4 4 3 12 19 19 19 7 Anti-sigma-K factor rskA GREB1 PF15782.5 CDI73853.1 - 0.014 12.6 18.9 0.018 12.2 18.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer BAF1_ABF1 PF04684.13 CDI73853.1 - 0.94 8.5 25.9 1.9 7.4 12.4 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Connexin PF00029.19 CDI73853.1 - 4.9 6.8 20.8 2.3 7.9 0.5 2.1 2 0 0 2 2 2 0 Connexin RIFIN PF02009.16 CDI73853.1 - 5.1 6.9 18.9 7.3 6.4 18.9 1.1 1 0 0 1 1 1 0 Rifin SLC12 PF03522.15 CDI73853.1 - 8.9 5.2 28.9 12 4.7 28.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PIG-U PF06728.13 CDI73854.1 - 0.033 13.3 3.2 1.4 7.9 0.1 2.2 2 0 0 2 2 2 0 GPI transamidase subunit PIG-U DDHD PF02862.17 CDI73854.1 - 0.062 13.5 5.8 0.79 9.8 1.9 2.2 2 0 0 2 2 2 0 DDHD domain Gti1_Pac2 PF09729.9 CDI73854.1 - 0.13 12.3 7.7 0.68 10.0 1.8 2.3 2 0 0 2 2 2 0 Gti1/Pac2 family Spt20 PF12090.8 CDI73854.1 - 0.19 11.3 37.7 0.28 10.8 16.2 2.3 2 0 0 2 2 2 0 Spt20 family EPL1 PF10513.9 CDI73854.1 - 1.1 9.7 11.2 1.1 9.6 0.6 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Ctr PF04145.15 CDI73854.1 - 5.4 7.6 8.9 2.4 8.8 1.5 2.3 2 0 0 2 2 2 0 Ctr copper transporter family Presenilin PF01080.17 CDI73854.1 - 7.4 5.2 14.9 3.7 6.2 5.2 2.1 2 0 0 2 2 2 0 Presenilin SR-25 PF10500.9 CDI73855.1 - 0.0005 19.7 12.0 0.0005 19.7 12.0 19.3 20 2 0 20 20 20 7 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI73855.1 - 0.0015 17.5 4.3 0.0015 17.5 4.3 14.3 13 3 1 14 14 14 6 Protein of unknown function (DUF2722) RskA PF10099.9 CDI73856.1 - 5.5e-05 23.5 1.8 5.5e-05 23.5 1.8 2.1 2 0 0 2 2 2 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI73856.1 - 0.00068 19.3 18.8 0.00068 19.3 18.8 2.1 2 0 0 2 2 2 1 Spt20 family Trp_oprn_chp PF09534.10 CDI73856.1 - 0.0013 18.6 0.4 0.32 10.8 0.0 2.1 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) TFIIA PF03153.13 CDI73856.1 - 0.0014 18.7 11.5 0.0014 18.7 11.5 2.0 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 CDI73856.1 - 0.0065 15.6 8.2 0.0093 15.0 8.2 1.2 1 0 0 1 1 1 1 Solute carrier family 12 DUF2828 PF11443.8 CDI73856.1 - 0.013 13.7 4.9 0.02 13.0 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PRC2_HTH_1 PF18118.1 CDI73856.1 - 0.091 13.6 0.4 0.091 13.6 0.4 2.3 2 1 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain MPM1 PF17234.2 CDI73856.1 - 0.1 12.9 17.8 1.1 9.5 3.8 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 SPX PF03105.19 CDI73856.1 - 0.12 12.3 10.2 0.17 11.8 10.2 1.2 1 0 0 1 1 1 0 SPX domain DUF2722 PF10846.8 CDI73856.1 - 0.16 10.9 47.2 0.11 11.4 19.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) FHIPEP PF00771.20 CDI73856.1 - 0.22 9.9 7.1 0.54 8.7 0.2 2.0 2 0 0 2 2 2 0 FHIPEP family CLN3 PF02487.17 CDI73856.1 - 0.28 10.2 7.7 0.79 8.7 0.6 2.0 2 0 0 2 2 2 0 CLN3 protein Hid1 PF12722.7 CDI73856.1 - 0.42 8.7 11.7 0.49 8.5 11.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein OSTbeta PF15048.6 CDI73856.1 - 0.44 10.7 2.7 3 8.0 0.6 2.2 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein BRF1 PF07741.13 CDI73856.1 - 0.61 10.5 11.4 3.3 8.1 2.5 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF755 PF05501.11 CDI73856.1 - 0.77 10.0 39.5 0.063 13.5 19.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Peptidase_S49_N PF08496.10 CDI73856.1 - 0.77 9.8 9.7 3.6 7.6 2.8 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Thg1C PF14413.6 CDI73856.1 - 1.5 9.0 13.8 0.41 10.8 1.9 2.4 3 0 0 3 3 3 0 Thg1 C terminal domain UPF0524 PF15823.5 CDI73856.1 - 2 7.7 17.3 0.53 9.6 1.6 2.2 2 0 0 2 2 2 0 UPF0524 of C3orf70 HemX PF04375.14 CDI73856.1 - 2.1 7.5 27.3 0.35 10.1 7.5 2.0 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase G0-G1_switch_2 PF15103.6 CDI73856.1 - 2.2 8.8 11.2 8.1 6.9 2.3 2.3 2 0 0 2 2 2 0 G0/G1 switch protein 2 DUF1645 PF07816.11 CDI73856.1 - 2.8 8.5 19.0 11 6.6 19.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1645) V_ATPase_I PF01496.19 CDI73856.1 - 3.8 5.3 14.3 2.3 6.0 3.2 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family RAP1 PF07218.11 CDI73856.1 - 4.6 5.4 4.7 5.3 5.2 4.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PGA2 PF07543.12 CDI73856.1 - 6 6.8 14.6 0.16 11.9 1.3 2.1 2 0 0 2 2 2 0 Protein trafficking PGA2 DUF3506 PF12014.8 CDI73856.1 - 6.1 6.8 9.4 13 5.8 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3506) DUF1180 PF06679.12 CDI73856.1 - 6.5 7.1 8.5 2.7 8.4 3.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Lin-8 PF03353.15 CDI73856.1 - 7.6 6.0 22.9 0.36 10.4 8.0 2.0 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Roughex PF06020.11 CDI73856.1 - 8.2 5.4 25.4 0.067 12.3 6.3 2.1 2 0 0 2 2 2 0 Drosophila roughex protein ALMT PF11744.8 CDI73856.1 - 8.5 5.1 13.3 4.3 6.1 2.1 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter SARAF PF06682.12 CDI73857.1 - 3.9e-05 23.5 4.6 4.7e-05 23.2 4.6 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis EphA2_TM PF14575.6 CDI73857.1 - 4.1e-05 24.4 2.2 0.26 12.2 0.1 2.1 2 0 0 2 2 2 2 Ephrin type-A receptor 2 transmembrane domain CcmH PF03918.14 CDI73857.1 - 0.00014 21.2 4.3 0.054 12.8 0.3 2.0 2 0 0 2 2 2 2 Cytochrome C biogenesis protein DUF2615 PF11027.8 CDI73857.1 - 0.00014 21.9 0.8 0.35 11.0 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2615) DUF5385 PF17359.2 CDI73857.1 - 0.00017 21.3 0.6 0.26 10.8 0.1 2.1 2 0 0 2 2 2 2 Family of unknown function (DUF5385) Conotoxin PF02950.17 CDI73857.1 - 0.00032 21.6 9.9 0.11 13.5 0.8 2.2 2 0 0 2 2 2 2 Conotoxin FGF-BP1 PF06473.12 CDI73857.1 - 0.0007 19.5 15.2 0.011 15.6 2.7 2.1 2 0 0 2 2 2 2 FGF binding protein 1 (FGF-BP1) FSAP_sig_propep PF03032.15 CDI73857.1 - 0.0012 18.8 4.3 0.39 10.8 0.4 2.3 2 0 0 2 2 2 2 Frog skin active peptide family signal and propeptide OppC_N PF12911.7 CDI73857.1 - 0.0012 18.7 0.5 0.87 9.6 0.1 2.2 2 0 0 2 2 2 1 N-terminal TM domain of oligopeptide transport permease C Enkurin PF13864.6 CDI73857.1 - 0.0014 19.1 13.0 0.073 13.5 1.5 2.1 2 0 0 2 2 2 2 Calmodulin-binding T2SSC PF11356.8 CDI73857.1 - 0.002 18.0 10.3 0.092 12.6 1.7 2.0 2 0 0 2 2 2 2 Type II secretion system protein C Ac76 PF05814.11 CDI73857.1 - 0.0021 18.0 0.6 1.5 8.9 0.1 2.1 2 0 0 2 2 2 1 Orf76 (Ac76) Tmemb_9 PF05434.11 CDI73857.1 - 0.0024 17.8 7.6 0.2 11.6 1.8 2.1 2 0 0 2 2 2 2 TMEM9 DUF4199 PF13858.6 CDI73857.1 - 0.0026 18.2 5.1 0.6 10.5 0.5 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF4199) GRP PF07172.11 CDI73857.1 - 0.0026 18.4 3.7 0.7 10.6 0.1 2.1 2 0 0 2 2 2 1 Glycine rich protein family DUF5531 PF17671.1 CDI73857.1 - 0.0028 17.6 3.5 0.61 10.0 0.2 2.1 2 0 0 2 2 2 2 Family of unknown function (DUF5531) NicO PF03824.16 CDI73857.1 - 0.0045 16.4 5.7 0.48 9.7 1.1 2.0 1 1 1 2 2 2 2 High-affinity nickel-transport protein RskA PF10099.9 CDI73857.1 - 0.0065 16.8 10.7 0.15 12.3 2.1 2.1 1 1 1 2 2 2 2 Anti-sigma-K factor rskA OAD_gamma PF04277.13 CDI73857.1 - 0.0071 16.9 0.0 3.1 8.4 0.0 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF2946 PF11162.8 CDI73857.1 - 0.0072 17.0 4.3 1.3 9.7 0.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2946) Presenilin PF01080.17 CDI73857.1 - 0.0076 15.1 5.3 0.009 14.8 5.3 1.1 1 0 0 1 1 1 1 Presenilin Virul_fac_BrkB PF03631.15 CDI73857.1 - 0.01 15.5 2.0 1.9 8.0 0.7 2.0 2 0 0 2 2 2 0 Virulence factor BrkB DUF3357 PF11837.8 CDI73857.1 - 0.01 16.3 2.3 2.8 8.4 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) DUF2149 PF09919.9 CDI73857.1 - 0.012 15.9 3.5 2.4 8.5 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2149) Pex24p PF06398.11 CDI73857.1 - 0.013 14.5 1.8 1.8 7.5 0.1 2.0 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin ETRAMP PF09716.10 CDI73857.1 - 0.013 15.5 0.2 6.9 6.8 0.0 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Rer1 PF03248.13 CDI73857.1 - 0.013 15.2 6.1 0.81 9.4 0.5 2.1 2 0 0 2 2 2 0 Rer1 family DUF2877 PF11392.8 CDI73857.1 - 0.014 16.1 2.6 3.4 8.4 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2877) DUF3394 PF11874.8 CDI73857.1 - 0.015 15.0 5.8 0.22 11.2 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3394) SIT PF15330.6 CDI73857.1 - 0.017 15.6 5.9 0.017 15.6 5.9 2.1 1 1 1 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT ABC2_membrane_2 PF12679.7 CDI73857.1 - 0.028 13.7 8.5 0.71 9.1 1.2 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein Rpp20 PF12328.8 CDI73857.1 - 0.03 14.3 5.7 1.1 9.2 0.1 2.1 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P TMEM208_SND2 PF05620.11 CDI73857.1 - 0.035 13.9 7.9 0.83 9.4 1.1 2.2 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Zip PF02535.22 CDI73857.1 - 0.037 13.2 1.3 0.088 12.0 1.3 1.6 1 1 0 1 1 1 0 ZIP Zinc transporter DUF1430 PF07242.11 CDI73857.1 - 0.04 14.2 0.6 8.9 6.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) DUF2973 PF11189.8 CDI73857.1 - 0.041 14.0 8.3 1 9.5 1.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2973) TMEM52 PF14979.6 CDI73857.1 - 0.05 13.5 4.7 3 7.8 0.4 2.2 2 0 0 2 2 2 0 Transmembrane 52 GspL_C PF12693.7 CDI73857.1 - 0.05 13.4 37.6 0.14 11.9 14.8 2.2 1 1 1 2 2 2 0 GspL periplasmic domain ORC_WH_C PF18137.1 CDI73857.1 - 0.053 13.6 4.9 0.076 13.1 4.9 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Peptidase_M56 PF05569.11 CDI73857.1 - 0.055 12.7 2.0 0.068 12.4 2.0 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 HemY_N PF07219.13 CDI73857.1 - 0.063 13.5 1.9 4.8 7.4 0.1 2.1 2 0 0 2 2 2 0 HemY protein N-terminus ABC_membrane PF00664.23 CDI73857.1 - 0.068 12.8 0.3 9.1 5.8 0.0 2.1 2 0 0 2 2 2 0 ABC transporter transmembrane region EOS1 PF12326.8 CDI73857.1 - 0.075 13.0 0.3 0.095 12.6 0.3 1.2 1 0 0 1 1 1 0 N-glycosylation protein NPH3 PF03000.14 CDI73857.1 - 0.092 12.4 8.3 1.3 8.6 1.5 2.1 2 0 0 2 2 2 0 NPH3 family PDDEXK_6 PF04720.12 CDI73857.1 - 0.1 12.5 5.7 2.2 8.2 0.2 2.0 2 0 0 2 2 2 0 PDDEXK-like family of unknown function CNDH2_N PF06278.11 CDI73857.1 - 0.12 12.6 11.3 1.3 9.2 1.5 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal DUF4064 PF13273.6 CDI73857.1 - 0.12 12.7 5.1 4.4 7.6 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) XK-related PF09815.9 CDI73857.1 - 0.13 11.3 3.6 0.15 11.1 3.6 1.1 1 0 0 1 1 1 0 XK-related protein UPF0542 PF15086.6 CDI73857.1 - 0.13 12.2 2.7 4.2 7.4 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 TIMELESS PF04821.14 CDI73857.1 - 0.13 11.5 16.9 0.28 10.4 4.9 2.0 1 1 0 2 2 2 0 Timeless protein MTABC_N PF16185.5 CDI73857.1 - 0.14 11.7 6.1 2.2 7.7 0.8 2.0 2 0 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region DBC1 PF14443.6 CDI73857.1 - 0.16 12.0 4.7 5.5 7.0 0.5 2.1 2 0 0 2 2 2 0 DBC1 TMEM154 PF15102.6 CDI73857.1 - 0.17 11.8 2.4 9.2 6.2 0.2 2.1 1 1 0 2 2 2 0 TMEM154 protein family MFS_Mycoplasma PF07672.13 CDI73857.1 - 0.17 11.2 6.3 2.6 7.2 0.7 2.0 2 0 0 2 2 2 0 Mycoplasma MFS transporter ABC_export PF16962.5 CDI73857.1 - 0.17 10.3 1.2 5.2 5.4 0.1 2.0 2 0 0 2 2 2 0 Putative ABC exporter DUF4492 PF14899.6 CDI73857.1 - 0.17 11.8 4.9 3.5 7.6 0.3 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4492) OPA3 PF07047.12 CDI73857.1 - 0.2 11.4 7.5 1.7 8.4 1.3 2.1 2 0 0 2 2 2 0 Optic atrophy 3 protein (OPA3) Scs3p PF10261.9 CDI73857.1 - 0.2 11.1 9.1 1.8 8.0 0.8 2.0 1 1 1 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF3671 PF12420.8 CDI73857.1 - 0.21 11.6 0.0 26 4.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF2214 PF09980.9 CDI73857.1 - 0.24 11.2 4.0 5.5 6.8 0.5 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2214) Herpes_glycop PF01528.16 CDI73857.1 - 0.24 10.2 0.3 7.4 5.3 0.2 2.0 2 0 0 2 2 2 0 Herpesvirus glycoprotein M O-antigen_lig PF13425.6 CDI73857.1 - 0.25 10.1 2.0 0.53 9.0 2.0 1.5 1 1 0 1 1 1 0 O-antigen ligase like membrane protein Ly49 PF08391.10 CDI73857.1 - 0.32 11.4 17.7 1.8 9.0 3.7 2.2 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region DUF3169 PF11368.8 CDI73857.1 - 0.33 10.4 0.8 16 4.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) DUF2227 PF09988.9 CDI73857.1 - 0.34 10.8 5.7 5.3 6.9 0.9 2.0 2 0 0 2 2 2 0 Uncharacterized metal-binding protein (DUF2227) TMEM51 PF15345.6 CDI73857.1 - 0.59 9.9 15.2 1.2 9.0 1.9 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 m04gp34like PF12216.8 CDI73857.1 - 0.72 9.4 2.7 15 5.0 0.1 2.0 1 1 1 2 2 2 0 Immune evasion protein Stig1 PF04885.13 CDI73857.1 - 0.81 10.2 4.9 11 6.5 0.9 2.0 2 0 0 2 2 2 0 Stigma-specific protein, Stig1 DUF4643 PF15485.6 CDI73857.1 - 0.84 9.4 11.7 2.4 7.9 2.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4643) GWT1 PF06423.12 CDI73857.1 - 0.96 9.6 2.7 17 5.5 0.3 2.1 2 0 0 2 2 2 0 GWT1 DUF4834 PF16118.5 CDI73857.1 - 1.2 10.1 21.4 1.2 10.1 4.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) DUF2681 PF10883.8 CDI73857.1 - 1.4 9.3 23.4 4.2 7.8 7.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) 7TM_GPCR_Srv PF10323.9 CDI73857.1 - 1.6 8.0 3.9 16 4.7 0.5 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv DUF4611 PF15387.6 CDI73857.1 - 2 8.7 10.7 6 7.2 2.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DUF3290 PF11694.8 CDI73857.1 - 2 8.4 15.7 4.5 7.2 3.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) SID-1_RNA_chan PF13965.6 CDI73857.1 - 2.1 6.6 4.0 12 4.2 4.0 1.9 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Mit_ribos_Mrp51 PF11709.8 CDI73857.1 - 2.3 7.8 16.7 13 5.3 16.4 1.8 1 1 0 1 1 1 0 Mitochondrial ribosomal protein subunit DUF1180 PF06679.12 CDI73857.1 - 2.3 8.6 14.6 3 8.2 3.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1180) EIIBC-GUT_N PF03612.14 CDI73857.1 - 2.4 7.9 7.8 7.6 6.2 0.4 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus RAB3GAP2_N PF14655.6 CDI73857.1 - 2.6 7.2 21.2 0.27 10.4 4.5 2.0 1 1 1 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus ANAPC_CDC26 PF10471.9 CDI73857.1 - 2.6 9.0 37.9 1.8 9.4 13.6 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Dpy19 PF10034.9 CDI73857.1 - 2.6 6.1 10.8 2.9 6.0 1.3 2.0 1 1 1 2 2 2 0 Q-cell neuroblast polarisation DivIC PF04977.15 CDI73857.1 - 2.7 7.8 30.9 3.6 7.4 11.9 2.1 2 0 0 2 2 2 0 Septum formation initiator CcdA PF07362.12 CDI73857.1 - 2.7 8.5 8.2 6.7 7.2 1.3 2.2 2 0 0 2 2 2 0 Post-segregation antitoxin CcdA WBP-1 PF11669.8 CDI73857.1 - 2.8 8.6 10.8 6.6 7.4 1.1 2.1 1 1 1 2 2 2 0 WW domain-binding protein 1 DUF2844 PF11005.8 CDI73857.1 - 3.4 7.7 14.5 5.8 6.9 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2844) Zn_peptidase PF04228.13 CDI73857.1 - 3.5 7.0 14.2 4.3 6.7 2.5 2.0 1 1 1 2 2 2 0 Putative neutral zinc metallopeptidase BRF1 PF07741.13 CDI73857.1 - 4 7.8 9.8 6.1 7.2 0.8 2.1 2 0 0 2 2 2 0 Brf1-like TBP-binding domain GTA_holin_3TM PF11351.8 CDI73857.1 - 4.1 8.0 15.5 3.6 8.1 2.1 2.1 2 0 0 2 2 2 0 Holin of 3TMs, for gene-transfer release EMC3_TMCO1 PF01956.16 CDI73857.1 - 4.3 7.0 14.2 5 6.8 3.6 2.0 1 1 1 2 2 2 0 Integral membrane protein EMC3/TMCO1-like LptF_LptG PF03739.14 CDI73857.1 - 4.4 6.1 7.3 3.3 6.5 0.6 2.0 1 1 1 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG KASH PF10541.9 CDI73857.1 - 4.9 7.5 14.5 4.4 7.6 1.2 2.4 2 1 0 2 2 2 0 Nuclear envelope localisation domain OATP PF03137.20 CDI73857.1 - 5.4 5.2 8.9 60 1.7 8.9 1.9 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family TrbI_Ftype PF09677.10 CDI73857.1 - 5.5 7.4 11.8 2.2 8.7 3.5 2.1 2 0 0 2 2 2 0 Type-F conjugative transfer system protein (TrbI_Ftype) V_ATPase_I PF01496.19 CDI73857.1 - 5.7 4.7 15.6 11 3.8 15.6 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family WRNPLPNID PF15017.6 CDI73857.1 - 7.5 7.5 12.8 3.9 8.4 0.4 2.4 2 1 0 2 2 2 0 Putative WW-binding domain and destruction box DUF1892 PF08987.10 CDI73859.1 - 3.9 7.7 10.9 6.7 6.9 0.5 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1892) DUF2353 PF09789.9 CDI73860.1 - 0.003 17.0 15.0 0.0036 16.7 15.0 1.0 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) FH2 PF02181.23 CDI73860.1 - 0.0042 16.3 12.2 0.005 16.0 12.2 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain MbeD_MobD PF04899.12 CDI73860.1 - 0.0096 16.0 10.9 0.058 13.5 0.4 2.2 1 1 1 2 2 2 1 MbeD/MobD like DUF1664 PF07889.12 CDI73860.1 - 0.011 15.8 7.0 0.25 11.4 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HemX PF04375.14 CDI73860.1 - 0.014 14.7 14.0 0.015 14.6 14.0 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Golgin_A5 PF09787.9 CDI73860.1 - 0.022 14.2 18.4 0.026 14.0 18.4 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 NPV_P10 PF05531.12 CDI73860.1 - 0.043 14.3 2.3 0.055 13.9 2.3 1.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein ComGG PF14173.6 CDI73860.1 - 0.14 12.6 9.2 0.068 13.6 2.5 2.1 1 1 1 2 2 2 0 ComG operon protein 7 ATG16 PF08614.11 CDI73860.1 - 0.17 12.1 24.4 0.22 11.7 24.4 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Laminin_II PF06009.12 CDI73860.1 - 0.18 11.8 10.6 0.21 11.6 9.7 1.6 1 1 1 2 2 2 0 Laminin Domain II FUSC PF04632.12 CDI73860.1 - 0.41 9.1 8.6 0.42 9.1 8.6 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family KASH_CCD PF14662.6 CDI73860.1 - 0.51 10.1 23.4 4.3 7.1 4.3 1.9 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF1501 PF07394.12 CDI73860.1 - 0.59 9.1 5.7 0.66 9.0 5.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Spc7 PF08317.11 CDI73860.1 - 0.71 8.7 19.6 0.87 8.4 19.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein ParE_toxin PF05016.15 CDI73860.1 - 0.72 10.5 3.2 1.4 9.6 3.2 1.6 1 1 0 1 1 1 0 ParE toxin of type II toxin-antitoxin system, parDE UDPGT PF00201.18 CDI73860.1 - 0.74 8.5 2.9 0.85 8.3 2.9 1.0 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase Phage_GPO PF05929.11 CDI73860.1 - 1.1 8.8 11.5 1.4 8.5 11.5 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Caps_synth_GfcC PF06251.11 CDI73860.1 - 1.4 8.5 6.4 1.6 8.3 6.4 1.2 1 0 0 1 1 1 0 Capsule biosynthesis GfcC PCRF PF03462.18 CDI73860.1 - 2.1 8.2 12.2 2.5 7.9 12.2 1.2 1 0 0 1 1 1 0 PCRF domain TMF_TATA_bd PF12325.8 CDI73860.1 - 2.3 8.5 23.0 17 5.7 23.0 1.9 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding FemAB PF02388.16 CDI73860.1 - 2.5 6.9 8.9 2.6 6.8 8.9 1.2 1 0 0 1 1 1 0 FemAB family MCU PF04678.13 CDI73860.1 - 2.6 8.1 11.7 3.2 7.8 11.3 1.3 1 1 0 1 1 1 0 Mitochondrial calcium uniporter Nup88 PF10168.9 CDI73860.1 - 3.4 5.4 12.8 3.6 5.3 12.8 1.1 1 0 0 1 1 1 0 Nuclear pore component DUF4446 PF14584.6 CDI73860.1 - 3.6 7.6 8.7 7.9 6.4 2.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) YabA PF06156.13 CDI73860.1 - 3.6 8.3 13.1 7.4 7.3 2.0 2.2 1 1 1 2 2 2 0 Initiation control protein YabA DUF724 PF05266.14 CDI73860.1 - 4.2 7.2 17.0 0.84 9.4 4.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) 5_nucleotid PF05761.14 CDI73860.1 - 4.6 6.0 7.9 5 5.9 7.9 1.1 1 0 0 1 1 1 0 5' nucleotidase family UPF0242 PF06785.11 CDI73860.1 - 4.7 7.3 17.5 6.2 6.9 17.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FapA PF03961.13 CDI73860.1 - 5.3 5.5 11.9 5.8 5.4 11.9 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A V_ATPase_I PF01496.19 CDI73860.1 - 6.2 4.6 10.7 5.9 4.7 10.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ERM PF00769.19 CDI73860.1 - 6.6 6.5 28.8 8.1 6.2 28.8 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family CENP-H PF05837.12 CDI73860.1 - 8.8 6.8 19.8 15 6.1 10.2 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) FlaC_arch PF05377.11 CDI73860.1 - 9.2 6.7 12.5 31 5.1 3.9 3.1 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) IF-2 PF11987.8 CDI73862.1 - 1.6e-10 41.1 0.1 6.5e-06 26.2 0.0 2.5 2 0 0 2 2 2 2 Translation-initiation factor 2 IMUP PF15761.5 CDI73862.1 - 0.038 14.7 5.1 0.038 14.7 5.1 1.8 2 0 0 2 2 2 0 Immortalisation up-regulated protein DUF2057 PF09829.9 CDI73862.1 - 9 6.4 10.4 0.37 10.9 3.3 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) RR_TM4-6 PF06459.12 CDI73863.1 - 0.73 9.6 30.0 0.94 9.3 30.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nop53 PF07767.11 CDI73863.1 - 1.8 7.9 36.0 2.1 7.6 36.0 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF3381 PF11861.8 CDI73863.1 - 4.7 7.0 29.4 6.2 6.6 29.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) AAA_23 PF13476.6 CDI73863.1 - 6.8 7.1 33.9 8.3 6.9 33.9 1.1 1 0 0 1 1 1 0 AAA domain Endostatin PF06482.11 CDI73863.1 - 8 5.8 31.2 9 5.7 31.2 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF2052 PF09747.9 CDI73863.1 - 8.3 6.5 30.4 9.1 6.4 30.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SDA1 PF05285.12 CDI73863.1 - 9.3 5.6 31.9 11 5.3 31.9 1.0 1 0 0 1 1 1 0 SDA1 Binary_toxB_3 PF17476.2 CDI73864.1 - 0.099 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Clostridial binary toxin B/anthrax toxin PA domain 3 Neur_chan_memb PF02932.16 CDI73866.1 - 4.7 7.2 11.1 1 9.3 1.3 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Roughex PF06020.11 CDI73866.1 - 6.1 5.8 10.4 11 5.0 10.4 1.6 1 0 0 1 1 1 0 Drosophila roughex protein Suf PF05843.14 CDI73866.1 - 7.8 6.4 19.9 1 9.3 10.1 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) HEAT PF02985.22 CDI73867.1 - 8e-05 22.6 9.6 0.91 10.0 0.0 5.2 5 0 0 5 5 5 3 HEAT repeat RskA PF10099.9 CDI73867.1 - 0.0013 19.0 20.4 0.0013 19.0 20.4 9.5 2 2 3 6 6 6 2 Anti-sigma-K factor rskA RIC3 PF15361.6 CDI73867.1 - 0.0088 16.4 3.2 0.0088 16.4 3.2 6.8 8 0 0 8 8 8 3 Resistance to inhibitors of cholinesterase homologue 3 HEAT_EZ PF13513.6 CDI73867.1 - 0.034 14.7 0.9 0.034 14.7 0.9 9.9 10 2 1 11 11 11 0 HEAT-like repeat Afi1 PF07792.12 CDI73867.1 - 1.1 9.7 60.8 0.96 9.9 1.7 6.6 6 0 0 6 6 6 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CompInhib_SCIN PF11546.8 CDI73868.1 - 0.23 11.5 5.4 0.25 11.4 5.4 1.1 1 0 0 1 1 1 0 Staphylococcal complement inhibitor SCIN Spore_II_R PF09551.10 CDI73868.1 - 6 7.3 13.3 7 7.1 13.3 1.0 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) DcuA_DcuB PF03605.14 CDI73869.1 - 1 8.2 6.8 1.6 7.6 6.8 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Scs3p PF10261.9 CDI73869.1 - 1.6 8.2 6.3 5 6.6 6.3 1.9 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF4179 PF13786.6 CDI73869.1 - 4 8.0 6.2 79 3.8 5.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) DUF4446 PF14584.6 CDI73869.1 - 6.7 6.7 8.8 16 5.4 8.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF2722 PF10846.8 CDI73871.1 - 0.0021 17.1 6.0 0.0021 17.1 6.0 8.1 6 2 1 8 8 8 2 Protein of unknown function (DUF2722) TPR_11 PF13414.6 CDI73873.1 - 3.1e-05 23.6 0.2 9.5e-05 22.0 0.2 1.8 1 0 0 1 1 1 1 TPR repeat TPR_17 PF13431.6 CDI73873.1 - 0.00039 20.6 0.1 0.0089 16.3 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDI73873.1 - 0.00098 19.6 1.9 0.00098 19.6 1.9 4.1 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI73873.1 - 0.0022 18.7 1.5 0.0022 18.7 1.5 5.4 6 1 0 6 6 6 2 Tetratricopeptide repeat RNA_pol_Rpc4 PF05132.14 CDI73873.1 - 0.0034 17.8 3.6 2 8.8 0.0 2.4 2 0 0 2 2 2 2 RNA polymerase III RPC4 TPR_2 PF07719.17 CDI73873.1 - 0.022 14.9 0.4 0.022 14.9 0.4 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDI73873.1 - 0.12 12.2 6.7 0.45 10.4 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat UPF0239 PF06783.11 CDI73873.1 - 0.33 11.1 4.3 1.1 9.5 4.3 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) CPSF100_C PF13299.6 CDI73873.1 - 3.5 7.8 8.3 1 9.5 1.0 3.0 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Crl PF07417.12 CDI73876.1 - 0.11 12.6 0.3 0.19 11.8 0.3 1.3 1 0 0 1 1 1 0 Sigma factor-binding transcriptional regulator Crl Plexin_cytopl PF08337.12 CDI73882.1 - 0.0058 15.4 4.6 0.0058 15.4 4.6 1.5 2 0 0 2 2 2 1 Plexin cytoplasmic RasGAP domain Velvet PF11754.8 CDI73882.1 - 0.045 13.7 12.2 0.062 13.2 12.2 1.2 1 0 0 1 1 1 0 Velvet factor SpoIIP PF07454.11 CDI73882.1 - 0.051 13.0 14.7 0.011 15.2 8.1 2.0 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Sin_N PF04801.13 CDI73882.1 - 0.089 12.0 27.9 0.12 11.6 27.9 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region HABP4_PAI-RBP1 PF04774.15 CDI73882.1 - 0.1 13.5 11.5 0.17 12.7 7.7 2.0 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family Kei1 PF08552.11 CDI73882.1 - 0.19 11.6 9.5 0.089 12.7 5.5 1.9 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 FYDLN_acid PF09538.10 CDI73882.1 - 0.35 11.6 10.4 0.18 12.5 5.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) SLC12 PF03522.15 CDI73882.1 - 0.38 9.7 16.2 0.5 9.3 16.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Rxt3 PF08642.10 CDI73882.1 - 0.9 10.3 11.0 1.2 9.9 6.4 2.2 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 TERB2 PF15101.6 CDI73882.1 - 1 9.4 25.3 0.07 13.2 13.6 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 V_ATPase_I PF01496.19 CDI73882.1 - 1.2 6.9 19.7 0.069 11.1 12.7 1.9 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Membralin PF09746.9 CDI73882.1 - 1.3 8.0 8.7 0.28 10.2 5.3 1.5 2 0 0 2 2 2 0 Tumour-associated protein HCO3_cotransp PF00955.21 CDI73882.1 - 1.3 7.7 2.5 1.8 7.3 2.5 1.2 1 0 0 1 1 1 0 HCO3- transporter family Baculo_PP31 PF05311.11 CDI73882.1 - 1.3 8.4 17.4 0.059 12.8 9.0 2.0 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) DUF4578 PF15147.6 CDI73882.1 - 1.5 9.7 25.9 2.2 9.1 15.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) VIR_N PF15912.5 CDI73882.1 - 1.6 8.3 13.1 0.19 11.3 6.8 1.9 2 0 0 2 2 2 0 Virilizer, N-terminal CAML PF14963.6 CDI73882.1 - 2.3 8.3 5.2 0.42 10.7 1.2 1.7 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand Hid1 PF12722.7 CDI73882.1 - 2.3 6.2 13.8 3.1 5.8 13.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1764 PF08576.10 CDI73882.1 - 2.6 9.0 15.8 1.3 10.0 8.7 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) PIP5K PF01504.18 CDI73882.1 - 3.2 6.9 15.8 0.29 10.3 9.4 1.9 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF3984 PF13136.6 CDI73882.1 - 3.3 7.0 14.8 1.6 8.1 10.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3984) O-antigen_lig PF13425.6 CDI73882.1 - 5 5.8 11.8 0.043 12.6 4.2 1.4 2 0 0 2 2 2 0 O-antigen ligase like membrane protein ATP-synt_E PF05680.12 CDI73882.1 - 5.9 7.3 18.8 0.2 12.0 7.9 2.2 2 0 0 2 2 2 0 ATP synthase E chain CDC45 PF02724.14 CDI73882.1 - 6.1 5.0 13.2 8.2 4.6 13.2 1.1 1 0 0 1 1 1 0 CDC45-like protein ALMT PF11744.8 CDI73882.1 - 6.5 5.5 13.1 0.43 9.4 7.6 1.7 2 0 0 2 2 2 0 Aluminium activated malate transporter DUF1980 PF09323.10 CDI73882.1 - 7 6.5 12.7 2.6 7.9 7.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) YABBY PF04690.13 CDI73882.1 - 7.1 7.2 14.3 1.3 9.5 8.1 2.0 2 0 0 2 2 2 0 YABBY protein MDFI PF15316.6 CDI73882.1 - 7.4 6.6 10.9 1.4 9.0 5.8 1.9 2 0 0 2 2 2 0 MyoD family inhibitor F-protein PF00469.20 CDI73882.1 - 8.7 5.9 15.8 0.67 9.5 9.5 1.9 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef Pro-rich PF15240.6 CDI73883.1 - 9.1 6.5 31.4 19 5.5 31.4 1.5 1 0 0 1 1 1 0 Proline-rich MID_MedPIWI PF18296.1 CDI73885.1 - 0.079 12.7 1.3 0.11 12.3 1.3 1.1 1 0 0 1 1 1 0 MID domain of medPIWI Presenilin PF01080.17 CDI73885.1 - 0.52 9.0 4.8 0.69 8.6 4.8 1.1 1 0 0 1 1 1 0 Presenilin CCSAP PF15748.5 CDI73885.1 - 0.52 10.4 7.1 0.66 10.1 7.1 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Herpes_pp85 PF04637.12 CDI73885.1 - 0.55 8.6 1.5 0.78 8.1 1.5 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Spore_coat_CotO PF14153.6 CDI73885.1 - 0.7 9.8 4.9 1 9.3 4.9 1.1 1 0 0 1 1 1 0 Spore coat protein CotO IMUP PF15761.5 CDI73885.1 - 1 10.1 8.5 2.4 8.9 8.5 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF4746 PF15928.5 CDI73885.1 - 2.7 7.3 6.4 3.4 7.0 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SelP_N PF04592.14 CDI73886.1 - 0.072 12.5 42.7 0.081 12.3 42.7 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SARAF PF06682.12 CDI73886.1 - 0.89 9.1 21.9 1 9.0 21.9 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Rtf2 PF04641.12 CDI73886.1 - 0.94 8.8 19.6 1.1 8.6 19.6 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger FAM76 PF16046.5 CDI73886.1 - 1 8.6 29.2 1.2 8.4 29.2 1.1 1 0 0 1 1 1 0 FAM76 protein Presenilin PF01080.17 CDI73886.1 - 1.9 7.2 27.7 2.1 7.0 27.7 1.0 1 0 0 1 1 1 0 Presenilin Gti1_Pac2 PF09729.9 CDI73886.1 - 4.1 7.5 21.1 5.4 7.1 21.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family FAM60A PF15396.6 CDI73886.1 - 4.6 7.2 22.0 5.2 7.0 22.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Sec62 PF03839.16 CDI73886.1 - 4.6 6.7 23.8 5.4 6.5 23.8 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 MAT1 PF06391.13 CDI73886.1 - 5.2 6.8 29.4 7.2 6.4 29.4 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 NicO PF03824.16 CDI73886.1 - 5.4 6.3 18.8 6 6.1 18.8 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein PNISR PF15996.5 CDI73886.1 - 6 7.1 27.0 7.2 6.8 27.0 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR V_ATPase_I PF01496.19 CDI73886.1 - 6.6 4.5 27.3 8.2 4.2 27.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI73886.1 - 8.9 5.2 18.3 10 5.1 18.3 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4569 PF15133.6 CDI73886.1 - 9.7 5.8 28.3 12 5.5 28.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) DUF2722 PF10846.8 CDI73887.1 - 0.00031 19.8 15.0 0.00037 19.6 15.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) VID27_N PF17748.1 CDI73887.1 - 0.0024 17.8 1.7 0.0033 17.3 1.7 1.2 1 0 0 1 1 1 1 VID27 N-terminal region SpoIIP PF07454.11 CDI73887.1 - 0.0054 16.2 1.7 0.0058 16.1 1.7 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) DUF1644 PF07800.12 CDI73887.1 - 0.0058 16.7 0.3 0.0089 16.1 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1644) MAT1 PF06391.13 CDI73887.1 - 0.0059 16.5 8.8 0.0076 16.1 8.8 1.2 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 eIF-3_zeta PF05091.12 CDI73887.1 - 0.0089 15.1 6.0 0.0095 15.0 6.0 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) WBP-1 PF11669.8 CDI73887.1 - 0.01 16.4 4.0 0.017 15.7 4.0 1.3 1 0 0 1 1 1 0 WW domain-binding protein 1 Helicase_C PF00271.31 CDI73887.1 - 0.016 15.5 2.3 0.2 12.0 2.3 2.1 1 1 0 1 1 1 0 Helicase conserved C-terminal domain SLC12 PF03522.15 CDI73887.1 - 0.028 13.5 4.6 0.031 13.3 4.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4834 PF16118.5 CDI73887.1 - 0.057 14.4 7.6 0.1 13.6 7.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) MAP65_ASE1 PF03999.12 CDI73887.1 - 0.064 11.9 9.1 0.073 11.8 9.1 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) UPF0560 PF10577.9 CDI73887.1 - 0.072 11.6 9.2 0.075 11.5 9.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Presenilin PF01080.17 CDI73887.1 - 0.073 11.8 8.4 0.093 11.5 8.4 1.1 1 0 0 1 1 1 0 Presenilin DUF4770 PF15994.5 CDI73887.1 - 0.098 12.9 9.3 0.13 12.5 9.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) V_ATPase_I PF01496.19 CDI73887.1 - 0.11 10.4 3.3 0.14 10.1 3.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PigN PF04987.14 CDI73887.1 - 0.11 11.3 3.3 0.15 10.8 3.3 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) RLL PF10036.9 CDI73887.1 - 0.12 12.2 11.5 0.14 11.9 11.5 1.2 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein Draxin PF15550.6 CDI73887.1 - 0.17 11.7 7.5 0.22 11.3 7.5 1.1 1 0 0 1 1 1 0 Draxin EarP PF10093.9 CDI73887.1 - 0.2 10.7 9.6 0.25 10.4 9.6 1.1 1 0 0 1 1 1 0 Elongation-Factor P (EF-P) rhamnosyltransferase EarP FHIPEP PF00771.20 CDI73887.1 - 0.24 9.8 9.1 0.042 12.3 5.6 1.5 1 1 0 1 1 1 0 FHIPEP family CLN3 PF02487.17 CDI73887.1 - 0.25 10.3 1.6 0.26 10.3 1.6 1.2 1 0 0 1 1 1 0 CLN3 protein MMR1 PF08505.10 CDI73887.1 - 0.27 11.5 9.7 0.35 11.1 9.7 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Peptidase_S49_N PF08496.10 CDI73887.1 - 0.29 11.2 7.7 0.47 10.5 7.7 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal OATP PF03137.20 CDI73887.1 - 0.39 8.9 2.9 0.46 8.7 2.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family VKG_Carbox PF05090.14 CDI73887.1 - 0.5 9.1 3.7 0.69 8.7 3.7 1.1 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase Rpp20 PF12328.8 CDI73887.1 - 0.69 9.9 12.1 1.5 8.8 12.1 1.5 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P ALMT PF11744.8 CDI73887.1 - 0.88 8.3 5.0 0.98 8.2 5.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Tam41_Mmp37 PF09139.11 CDI73887.1 - 0.99 8.8 9.1 1.2 8.5 9.1 1.1 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial AAA_23 PF13476.6 CDI73887.1 - 1.3 9.5 11.6 1.5 9.3 11.6 1.1 1 0 0 1 1 1 0 AAA domain G0-G1_switch_2 PF15103.6 CDI73887.1 - 1.5 9.3 7.5 0.46 10.9 3.9 1.8 2 0 0 2 2 2 0 G0/G1 switch protein 2 Coilin_N PF15862.5 CDI73887.1 - 1.9 8.3 11.8 3.2 7.5 11.8 1.4 1 0 0 1 1 1 0 Coilin N-terminus DUF3347 PF11827.8 CDI73887.1 - 1.9 8.7 12.2 2.6 8.2 12.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) DUF3731 PF12531.8 CDI73887.1 - 2 8.2 14.2 1 9.1 12.3 1.5 1 1 0 1 1 1 0 DNA-K related protein EIIBC-GUT_N PF03612.14 CDI73887.1 - 3.4 7.4 9.8 0.36 10.5 5.0 1.8 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus AUX_IAA PF02309.16 CDI73887.1 - 3.5 7.4 7.5 4.3 7.1 7.5 1.2 1 0 0 1 1 1 0 AUX/IAA family DUF2203 PF09969.9 CDI73887.1 - 8 7.2 10.9 2.7 8.7 5.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) SR-25 PF10500.9 CDI73888.1 - 4e-05 23.3 19.9 4e-05 23.3 19.9 13.7 7 4 6 14 14 14 4 Nuclear RNA-splicing-associated protein DUF4834 PF16118.5 CDI73888.1 - 0.00021 22.2 7.0 0.00021 22.2 7.0 15.7 10 4 4 14 14 14 2 Domain of unknown function (DUF4834) DUF3499 PF12005.8 CDI73889.1 - 0.012 16.2 6.9 0.012 16.2 6.9 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF3499) WDCP PF15390.6 CDI73889.1 - 0.029 12.8 13.4 0.041 12.3 13.4 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Anp1 PF03452.14 CDI73889.1 - 1.5 8.2 7.7 2.2 7.6 7.7 1.1 1 0 0 1 1 1 0 Anp1 SOBP PF15279.6 CDI73889.1 - 3.7 8.1 17.4 5.9 7.4 17.4 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein LMF1 PF06762.14 CDI73890.1 - 3.1e-13 49.7 3.3 3.8e-12 46.1 3.3 2.0 1 1 0 1 1 1 1 Lipase maturation factor DUF1635 PF07795.11 CDI73890.1 - 0.76 9.6 17.9 0.27 11.1 3.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Secretin_N_2 PF07655.13 CDI73890.1 - 1 9.9 16.6 2.3 8.8 16.6 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain SPX PF03105.19 CDI73890.1 - 2.8 7.8 17.3 0.85 9.5 0.7 2.1 2 0 0 2 2 2 0 SPX domain Corona_nucleoca PF00937.18 CDI73890.1 - 2.8 6.9 9.5 4.8 6.1 9.5 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein RskA PF10099.9 CDI73891.1 - 7.1e-05 23.2 8.4 8.3e-05 23.0 8.4 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA FAM199X PF15814.5 CDI73891.1 - 0.0069 15.5 19.0 0.0083 15.2 19.0 1.1 1 0 0 1 1 1 1 Protein family FAM199X AF-4 PF05110.13 CDI73891.1 - 0.068 11.3 28.0 0.1 10.7 28.0 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SprA-related PF12118.8 CDI73891.1 - 0.079 12.1 32.9 0.096 11.8 32.9 1.0 1 0 0 1 1 1 0 SprA-related family Ribosomal_60s PF00428.19 CDI73891.1 - 0.27 11.9 10.2 0.44 11.2 10.2 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein TFIIA PF03153.13 CDI73891.1 - 0.31 11.0 30.7 0.36 10.8 30.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3824 PF12868.7 CDI73891.1 - 0.31 11.7 15.0 0.54 10.9 15.0 1.4 1 1 0 1 1 1 0 Domain of unknwon function (DUF3824) Roughex PF06020.11 CDI73891.1 - 0.35 9.9 15.2 0.4 9.7 15.2 1.2 1 0 0 1 1 1 0 Drosophila roughex protein BAF1_ABF1 PF04684.13 CDI73891.1 - 1.1 8.2 20.8 1.4 7.9 20.8 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor MYT1 PF08474.11 CDI73891.1 - 1.4 8.8 17.4 1.6 8.6 17.4 1.0 1 0 0 1 1 1 0 Myelin transcription factor 1 Serinc PF03348.15 CDI73891.1 - 2.6 6.9 11.2 3 6.7 11.2 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Suf PF05843.14 CDI73891.1 - 4.7 7.1 19.9 5.8 6.8 19.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) eIF-3_zeta PF05091.12 CDI73891.1 - 5.4 5.9 16.1 6.3 5.7 16.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CCSAP PF15748.5 CDI73891.1 - 8 6.5 26.4 9.3 6.3 26.4 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DivIC PF04977.15 CDI73891.1 - 8.6 6.2 14.3 13 5.7 14.3 1.3 1 0 0 1 1 1 0 Septum formation initiator NUFIP1 PF10453.9 CDI73892.1 - 0.04 13.8 2.3 0.04 13.8 2.3 3.3 4 0 0 4 4 4 0 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) Hamartin PF04388.12 CDI73892.1 - 0.11 11.2 18.5 0.12 11.0 18.5 1.0 1 0 0 1 1 1 0 Hamartin protein OATP PF03137.20 CDI73892.1 - 0.13 10.5 6.0 0.17 10.1 6.0 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DcuA_DcuB PF03605.14 CDI73892.1 - 0.18 10.7 9.4 0.26 10.1 9.4 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter AMP-binding PF00501.28 CDI73892.1 - 0.21 10.1 4.2 0.24 9.9 4.2 1.1 1 0 0 1 1 1 0 AMP-binding enzyme TCP PF03634.13 CDI73892.1 - 0.47 11.0 20.7 0.68 10.5 20.7 1.2 1 0 0 1 1 1 0 TCP family transcription factor DUF3523 PF12037.8 CDI73892.1 - 0.91 8.8 25.6 1.1 8.5 25.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) Shadoo PF14999.6 CDI73892.1 - 0.97 9.5 7.7 1.7 8.8 7.7 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective FAM60A PF15396.6 CDI73892.1 - 0.99 9.4 15.7 1.1 9.2 15.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SID-1_RNA_chan PF13965.6 CDI73892.1 - 1.3 7.3 6.0 1.3 7.3 6.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RR_TM4-6 PF06459.12 CDI73892.1 - 1.8 8.3 17.9 2.5 7.9 17.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LRIF1 PF15741.5 CDI73892.1 - 2.1 6.8 22.1 2.3 6.7 22.1 1.0 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 O-antigen_lig PF13425.6 CDI73892.1 - 2.1 7.0 5.3 2.2 7.0 5.3 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF2464 PF10240.9 CDI73892.1 - 3.4 7.2 11.4 4.5 6.8 11.4 1.3 1 0 0 1 1 1 0 Multivesicular body subunit 12 Exonuc_VII_L PF02601.15 CDI73892.1 - 3.6 7.1 25.3 4.7 6.7 25.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3474 PF11960.8 CDI73892.1 - 4.4 7.5 6.9 7.1 6.8 6.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3474) Myc_N PF01056.18 CDI73892.1 - 4.5 7.1 15.2 5.7 6.7 15.2 1.1 1 0 0 1 1 1 0 Myc amino-terminal region eIF-3_zeta PF05091.12 CDI73892.1 - 5.9 5.7 20.3 8.7 5.2 20.3 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Croc_4 PF17691.1 CDI73892.1 - 6.2 6.9 9.9 4.6 7.3 8.4 1.6 1 1 0 1 1 1 0 Contingent replication of cDNA 4 CLN3 PF02487.17 CDI73892.1 - 6.7 5.6 9.9 7.8 5.4 9.9 1.3 1 0 0 1 1 1 0 CLN3 protein CSG2 PF16965.5 CDI73892.1 - 7.7 5.3 7.9 9.3 5.1 7.9 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator SLC12 PF03522.15 CDI73892.1 - 7.8 5.4 19.2 9.3 5.1 19.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RIFIN PF02009.16 CDI73892.1 - 9.7 6.0 18.6 12 5.7 18.6 1.0 1 0 0 1 1 1 0 Rifin Spt20 PF12090.8 CDI73893.1 - 8e-06 25.6 33.1 8e-06 25.6 33.1 4.5 2 1 0 2 2 2 1 Spt20 family eIF-3_zeta PF05091.12 CDI73893.1 - 0.0022 17.0 8.3 0.0022 17.0 8.3 3.8 2 1 1 3 3 3 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SPX PF03105.19 CDI73893.1 - 0.012 15.6 12.2 0.012 15.6 12.2 3.4 2 1 0 2 2 2 0 SPX domain Inj_translocase PF16928.5 CDI73894.1 - 0.021 14.3 1.5 0.021 14.3 1.5 5.7 3 2 1 5 5 5 0 DNA/protein translocase of phage P22 injectosome Orthopox_C10L PF07020.11 CDI73894.1 - 0.032 15.0 1.3 0.032 15.0 1.3 2.0 2 0 0 2 2 2 0 Orthopoxvirus C10L protein N6_N4_Mtase PF01555.18 CDI73894.1 - 0.18 11.5 0.7 2.1 8.0 0.7 2.3 1 1 0 1 1 1 0 DNA methylase LCE6A PF15858.5 CDI73895.1 - 0.0088 16.8 0.3 0.012 16.3 0.3 1.4 1 0 0 1 1 1 1 Late cornified envelope protein 6A family RskA PF10099.9 CDI73895.1 - 0.01 16.1 9.6 0.012 15.9 9.6 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI73895.1 - 0.14 11.8 10.5 0.2 11.3 10.5 1.2 1 0 0 1 1 1 0 Spt20 family FHIPEP PF00771.20 CDI73895.1 - 0.23 9.9 3.2 0.34 9.3 3.2 1.3 1 0 0 1 1 1 0 FHIPEP family Nop14 PF04147.12 CDI73895.1 - 0.26 9.4 24.5 0.29 9.3 24.5 1.1 1 0 0 1 1 1 0 Nop14-like family INSIG PF07281.12 CDI73895.1 - 0.26 10.9 0.6 0.31 10.7 0.6 1.2 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) Cwf_Cwc_15 PF04889.12 CDI73895.1 - 0.61 9.8 21.6 0.73 9.5 21.6 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ADP_ribosyl_GH PF03747.14 CDI73895.1 - 1.1 8.9 8.9 1.2 8.8 8.9 1.0 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase PPP4R2 PF09184.11 CDI73895.1 - 1.2 8.7 26.9 1.3 8.5 26.9 1.0 1 0 0 1 1 1 0 PPP4R2 AAA_23 PF13476.6 CDI73895.1 - 1.2 9.6 13.0 1.6 9.2 13.0 1.2 1 0 0 1 1 1 0 AAA domain DUF5523 PF17661.1 CDI73895.1 - 1.4 8.6 22.7 1.8 8.2 22.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) CDC27 PF09507.10 CDI73895.1 - 1.7 7.9 23.7 2.1 7.6 23.7 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SID-1_RNA_chan PF13965.6 CDI73895.1 - 1.9 6.8 2.9 2.2 6.6 2.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF3138 PF11336.8 CDI73895.1 - 2 6.9 8.4 2.1 6.9 8.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) HNF-1_N PF04814.13 CDI73895.1 - 2 9.0 11.9 2.1 8.9 11.9 1.0 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Sporozoite_P67 PF05642.11 CDI73895.1 - 2.1 6.4 14.8 2.3 6.2 14.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TAP42 PF04177.12 CDI73895.1 - 2.1 7.4 19.1 2.6 7.1 19.1 1.1 1 0 0 1 1 1 0 TAP42-like family DUF4207 PF13904.6 CDI73895.1 - 2.4 7.8 19.5 3.1 7.4 19.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) BAT2_N PF07001.11 CDI73895.1 - 2.7 8.4 10.5 3 8.2 10.5 1.1 1 0 0 1 1 1 0 BAT2 N-terminus BUD22 PF09073.10 CDI73895.1 - 2.9 7.1 22.9 3.4 6.9 22.9 1.1 1 0 0 1 1 1 0 BUD22 V_ATPase_I PF01496.19 CDI73895.1 - 3.2 5.5 13.3 3.7 5.3 13.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MID_MedPIWI PF18296.1 CDI73895.1 - 4.6 7.0 7.4 5.1 6.8 7.4 1.1 1 0 0 1 1 1 0 MID domain of medPIWI Serinc PF03348.15 CDI73895.1 - 4.8 6.0 7.7 5.5 5.8 7.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DNA_pol_phi PF04931.13 CDI73895.1 - 7.7 4.5 30.6 12 3.9 30.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi TMEM174 PF15029.6 CDI73895.1 - 8.1 6.1 6.6 9.8 5.8 6.6 1.1 1 0 0 1 1 1 0 Transmembrane protein 174 EIF4E-T PF10477.9 CDI73897.1 - 0.07 12.0 10.9 0.11 11.3 10.9 1.3 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF1980 PF09323.10 CDI73897.1 - 0.32 10.9 4.4 0.6 10.0 4.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Mlh1_C PF16413.5 CDI73897.1 - 0.46 9.8 7.5 0.8 9.0 7.5 1.3 1 0 0 1 1 1 0 DNA mismatch repair protein Mlh1 C-terminus Connexin PF00029.19 CDI73897.1 - 0.97 9.1 4.2 1.4 8.6 4.2 1.2 1 0 0 1 1 1 0 Connexin Peptidase_S49_N PF08496.10 CDI73897.1 - 0.97 9.5 6.5 2 8.4 6.5 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal eIF-3_zeta PF05091.12 CDI73897.1 - 1 8.3 12.8 1.6 7.6 12.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SpoIIP PF07454.11 CDI73897.1 - 1.4 8.3 10.2 2.3 7.6 10.2 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) OATP PF03137.20 CDI73897.1 - 1.8 6.7 6.1 2.9 6.1 6.1 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family FAM60A PF15396.6 CDI73897.1 - 2 8.4 7.0 0.29 11.1 3.0 1.7 2 0 0 2 2 2 0 Protein Family FAM60A DUF3408 PF11888.8 CDI73897.1 - 2.4 8.3 10.5 8.9 6.4 10.5 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Spt20 PF12090.8 CDI73897.1 - 2.4 7.7 39.3 0.1 12.2 33.0 1.8 2 0 0 2 2 2 0 Spt20 family RR_TM4-6 PF06459.12 CDI73897.1 - 2.4 7.9 16.0 0.12 12.1 9.2 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF4834 PF16118.5 CDI73897.1 - 2.5 9.1 12.9 6.8 7.7 12.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) ATAD4 PF15321.6 CDI73897.1 - 2.6 9.5 6.6 2.3 9.6 4.4 2.1 2 0 0 2 2 1 0 ATPase family AAA domain containing 4 UPF0560 PF10577.9 CDI73897.1 - 3.7 5.9 16.9 6 5.2 16.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PIP5K PF01504.18 CDI73897.1 - 6 6.0 7.9 11 5.1 7.9 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase EPL1 PF10513.9 CDI73897.1 - 6.3 7.2 12.8 3.9 7.8 9.5 2.1 2 1 0 2 2 2 0 Enhancer of polycomb-like V_ATPase_I PF01496.19 CDI73897.1 - 8.6 4.1 9.3 12 3.7 9.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MCM_bind PF09739.9 CDI73898.1 - 0.67 8.3 12.6 0.74 8.2 12.6 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Nuc_deoxyri_tr2 PF15891.5 CDI73898.1 - 1.6 9.1 6.0 2.3 8.6 6.0 1.4 1 1 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase like Presenilin PF01080.17 CDI73898.1 - 5.3 5.7 11.8 5.8 5.6 11.8 1.0 1 0 0 1 1 1 0 Presenilin LMBR1 PF04791.16 CDI73898.1 - 9.6 5.0 7.6 11 4.8 7.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Pex14_N PF04695.13 CDI73899.1 - 0.35 11.5 9.4 0.48 11.1 9.4 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RR_TM4-6 PF06459.12 CDI73899.1 - 0.37 10.6 7.3 0.37 10.6 7.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Borrelia_P83 PF05262.11 CDI73899.1 - 0.48 8.9 8.0 0.54 8.7 8.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Presenilin PF01080.17 CDI73899.1 - 0.82 8.4 8.2 0.82 8.4 8.2 1.1 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 CDI73899.1 - 0.89 8.6 9.7 1.1 8.2 9.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF3682 PF12446.8 CDI73899.1 - 1 9.9 13.8 1.7 9.2 13.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) DUF3930 PF13067.6 CDI73899.1 - 1.6 9.0 3.4 3 8.2 3.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3930) DUF2967 PF11179.8 CDI73899.1 - 1.7 6.7 12.7 2 6.4 12.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) DUF2058 PF09831.9 CDI73899.1 - 2.6 8.2 16.2 3.9 7.6 16.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) Neur_chan_memb PF02932.16 CDI73899.1 - 3.1 7.8 5.5 3.3 7.7 5.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.10 CDI73899.1 - 3.5 6.2 7.0 3.5 6.2 7.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Band_3_cyto PF07565.13 CDI73899.1 - 4 7.1 8.7 5.3 6.8 8.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF5349 PF17298.2 CDI73899.1 - 4.9 6.8 9.0 6.6 6.4 9.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5349) V_ATPase_I PF01496.19 CDI73899.1 - 5.1 4.9 7.8 6.1 4.6 7.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3464 PF11947.8 CDI73899.1 - 6.4 6.5 10.8 13 5.6 10.8 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF3408 PF11888.8 CDI73899.1 - 7.5 6.7 14.2 14 5.8 14.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) RskA PF10099.9 CDI73901.1 - 0.00088 19.6 9.4 0.00088 19.6 9.4 7.5 1 1 5 6 6 6 2 Anti-sigma-K factor rskA DUF755 PF05501.11 CDI73901.1 - 0.0061 16.8 23.9 0.0061 16.8 23.9 8.7 6 3 1 7 7 7 2 Domain of unknown function (DUF755) SR-25 PF10500.9 CDI73901.1 - 0.078 12.6 112.8 0.018 14.7 21.3 5.6 4 1 1 5 5 5 0 Nuclear RNA-splicing-associated protein DUF3040 PF11239.8 CDI73901.1 - 0.43 10.9 3.0 0.81 10.0 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Plug_translocon PF10559.9 CDI73903.1 - 2.1e-18 65.8 0.0 3.6e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Plug domain of Sec61p SecY PF00344.20 CDI73903.1 - 5.8e-12 45.5 0.9 7.9e-12 45.0 0.9 1.2 1 0 0 1 1 1 1 SecY translocase RRM_1 PF00076.22 CDI73904.1 - 2e-30 104.4 0.0 3.4e-11 42.8 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CDI73904.1 - 0.0021 18.1 0.0 4.9 7.3 0.0 3.1 3 0 0 3 3 3 2 Limkain b1 RRM_3 PF08777.11 CDI73904.1 - 0.0083 16.1 0.0 3.7 7.7 0.0 3.2 3 0 0 3 3 3 1 RNA binding motif DUF3343 PF11823.8 CDI73904.1 - 0.19 11.2 0.0 4.6 6.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3343) Guanylate_cyc PF00211.20 CDI73907.1 - 5.1e-18 65.3 0.1 3.2e-10 39.9 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain SnoaL_4 PF13577.6 CDI73907.1 - 0.18 11.9 5.3 6.5 6.9 0.0 3.6 3 0 0 3 3 3 0 SnoaL-like domain DUF2722 PF10846.8 CDI73908.1 - 0.00016 20.8 0.8 0.00016 20.8 0.8 16.0 11 3 3 15 15 15 7 Protein of unknown function (DUF2722) SR-25 PF10500.9 CDI73908.1 - 0.001 18.8 22.8 0.001 18.8 22.8 14.2 11 2 2 14 14 14 4 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI73908.1 - 0.0026 17.8 2.4 0.0026 17.8 2.4 20.7 15 4 1 16 16 16 6 Unstructured region C-term to UIM in Ataxin3 C2 PF00168.30 CDI73909.1 - 2.1e-19 69.7 0.1 6.2e-12 45.7 0.0 4.0 4 0 0 4 4 4 3 C2 domain ABC_tran_CTD PF16326.5 CDI73909.1 - 0.51 10.6 5.4 17 5.8 0.4 3.1 3 0 0 3 3 3 0 ABC transporter C-terminal domain PCI PF01399.27 CDI73910.1 - 4.7e-12 46.3 0.2 8.8e-12 45.5 0.2 1.4 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 CDI73910.1 - 0.018 15.1 0.1 0.51 10.6 0.0 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF3774 PF12609.8 CDI73911.1 - 0.59 11.2 4.3 8.8 7.4 1.2 2.9 3 0 0 3 3 3 0 Wound-induced protein Nucleoporin_FG PF13634.6 CDI73912.1 - 4.8e-10 40.2 77.1 1.7e-06 28.8 40.0 12.8 6 3 3 10 10 10 5 Nucleoporin FG repeat region Nucleoporin2 PF04096.14 CDI73912.1 - 0.0023 18.1 0.0 0.0023 18.1 0.0 4.1 4 1 0 4 4 4 1 Nucleoporin autopeptidase DUF1712 PF08217.11 CDI73913.1 - 0.24 9.8 19.3 0.0086 14.6 12.7 1.8 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1712) LCD1 PF09798.9 CDI73913.1 - 0.32 9.5 0.0 0.32 9.5 0.0 2.5 2 2 0 2 2 2 0 DNA damage checkpoint protein Shadoo PF14999.6 CDI73913.1 - 0.36 10.9 23.9 0.029 14.5 6.2 3.1 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective SARAF PF06682.12 CDI73913.1 - 2.1 7.9 37.3 1.6 8.3 25.8 2.5 2 1 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis RAP1 PF07218.11 CDI73913.1 - 2.1 6.5 10.2 2.6 6.2 10.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Pinin_SDK_memA PF04696.13 CDI73913.1 - 2.6 8.1 37.4 0.61 10.2 12.3 3.4 3 0 0 3 3 3 0 pinin/SDK/memA/ protein conserved region GT87 PF09594.10 CDI73913.1 - 5.4 6.6 15.7 5 6.8 1.3 2.7 2 1 0 2 2 2 0 Glycosyltransferase family 87 BAF1_ABF1 PF04684.13 CDI73913.1 - 8.4 5.3 46.5 0.15 11.1 26.5 2.8 2 1 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Spt20 PF12090.8 CDI73914.1 - 0.00031 20.4 42.0 0.00048 19.8 10.4 8.1 6 1 1 7 7 7 3 Spt20 family RskA PF10099.9 CDI73914.1 - 0.0018 18.6 0.3 0.0018 18.6 0.3 9.5 4 3 4 8 8 8 3 Anti-sigma-K factor rskA Pap_E4 PF02711.14 CDI73914.1 - 0.05 14.6 0.9 0.05 14.6 0.9 8.4 8 2 2 10 10 10 0 E4 protein ESM4 PF15952.5 CDI73914.1 - 0.4 11.1 0.0 0.4 11.1 0.0 7.0 5 1 1 6 6 6 0 Enhancer of split M4 family DUF4746 PF15928.5 CDI73915.1 - 0.0038 16.7 3.2 0.0038 16.7 3.2 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4746) DUF2052 PF09747.9 CDI73915.1 - 0.05 13.7 37.7 0.23 11.6 22.2 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) GerE PF00196.19 CDI73915.1 - 0.057 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family Tim54 PF11711.8 CDI73915.1 - 0.06 12.1 25.2 0.022 13.6 9.4 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF3807 PF12720.7 CDI73915.1 - 0.14 12.4 42.6 0.74 10.1 22.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Cwf_Cwc_15 PF04889.12 CDI73915.1 - 0.15 11.8 30.9 0.23 11.2 16.0 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Gti1_Pac2 PF09729.9 CDI73915.1 - 0.17 12.0 27.5 0.46 10.6 13.9 2.3 2 0 0 2 2 2 0 Gti1/Pac2 family Rrf2 PF02082.20 CDI73915.1 - 0.2 12.1 0.1 0.2 12.1 0.1 2.3 3 0 0 3 3 2 0 Transcriptional regulator CLN3 PF02487.17 CDI73915.1 - 0.2 10.6 26.6 0.039 13.0 11.2 2.1 2 0 0 2 2 2 0 CLN3 protein HTH_23 PF13384.6 CDI73915.1 - 0.29 11.0 0.1 0.29 11.0 0.1 2.7 3 0 0 3 3 2 0 Homeodomain-like domain DUF966 PF06136.13 CDI73915.1 - 0.31 10.7 31.9 0.37 10.5 31.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Vfa1 PF08432.10 CDI73915.1 - 0.33 11.3 31.3 1.5 9.2 17.4 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Slu7 PF11708.8 CDI73915.1 - 0.36 10.5 34.0 0.6 9.8 17.7 2.1 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor NPR3 PF03666.13 CDI73915.1 - 0.4 9.4 28.9 0.17 10.7 14.0 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Afi1 PF07792.12 CDI73915.1 - 0.42 11.1 30.4 1.4 9.4 15.3 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking eIF-3_zeta PF05091.12 CDI73915.1 - 0.53 9.2 43.7 0.42 9.5 19.9 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PTPRCAP PF15713.5 CDI73915.1 - 0.69 10.2 36.4 0.27 11.5 17.9 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Lin-8 PF03353.15 CDI73915.1 - 0.7 9.4 45.5 0.17 11.4 26.8 2.0 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist TRAP_alpha PF03896.16 CDI73915.1 - 0.73 9.0 18.4 0.52 9.5 8.4 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit V_ATPase_I PF01496.19 CDI73915.1 - 0.81 7.5 35.6 0.29 9.0 18.4 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Cyclin_N2 PF16500.5 CDI73915.1 - 0.99 10.2 31.6 0.062 14.0 16.3 2.2 2 0 0 2 2 2 0 N-terminal region of cyclin_N Band_3_cyto PF07565.13 CDI73915.1 - 1.2 8.8 32.3 1.7 8.4 16.2 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain RR_TM4-6 PF06459.12 CDI73915.1 - 1.4 8.7 37.4 1.4 8.6 21.0 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Ferlin_C PF16165.5 CDI73915.1 - 2.4 8.1 14.3 4.8 7.1 5.9 2.3 2 0 0 2 2 2 0 Ferlin C-terminus Rtf2 PF04641.12 CDI73915.1 - 3.3 7.0 29.9 4.4 6.6 16.7 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger eIF3_subunit PF08597.10 CDI73915.1 - 3.4 7.5 34.9 2 8.2 5.7 2.2 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit DUF3381 PF11861.8 CDI73915.1 - 4.7 7.0 42.7 2.1 8.1 9.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) ASC PF00858.24 CDI73915.1 - 4.9 6.0 17.5 2.6 6.9 8.4 2.1 2 0 0 2 2 2 0 Amiloride-sensitive sodium channel CDC45 PF02724.14 CDI73915.1 - 5.2 5.2 35.9 2.2 6.5 6.3 2.0 2 0 0 2 2 2 0 CDC45-like protein DREPP PF05558.12 CDI73915.1 - 6.6 6.6 9.7 0.46 10.3 1.5 2.1 2 0 0 2 2 2 0 DREPP plasma membrane polypeptide Kei1 PF08552.11 CDI73915.1 - 7.2 6.4 23.9 4.1 7.2 3.2 2.3 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4050 PF13259.6 CDI73915.1 - 8.1 6.7 34.4 1.6 9.0 4.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4050) SPX PF03105.19 CDI73915.1 - 8.2 6.2 34.3 2.2 8.1 19.8 2.0 2 0 0 2 2 2 0 SPX domain PPL5 PF18168.1 CDI73915.1 - 8.4 5.6 25.8 5.8 6.1 4.0 2.1 2 0 0 2 2 2 0 Prim-pol family 5 Spore_coat_CotO PF14153.6 CDI73915.1 - 9.1 6.2 46.2 7 6.5 11.9 2.3 2 0 0 2 2 2 0 Spore coat protein CotO LTV PF04180.14 CDI73915.1 - 9.7 5.8 32.3 5.5 6.6 17.6 2.1 2 0 0 2 2 2 0 Low temperature viability protein BAF1_ABF1 PF04684.13 CDI73916.1 - 0.013 14.6 24.1 0.015 14.4 24.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Ureide_permease PF07168.11 CDI73916.1 - 0.015 14.1 10.9 0.017 13.9 10.9 1.1 1 0 0 1 1 1 0 Ureide permease SID-1_RNA_chan PF13965.6 CDI73916.1 - 0.019 13.4 9.3 0.02 13.3 9.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ArsP_2 PF11449.8 CDI73916.1 - 0.034 13.3 5.6 0.047 12.9 5.6 1.3 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter Peptidase_S49_N PF08496.10 CDI73916.1 - 0.39 10.8 21.2 0.47 10.5 21.2 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ctr PF04145.15 CDI73916.1 - 0.44 11.2 12.8 0.5 11.0 12.8 1.1 1 0 0 1 1 1 0 Ctr copper transporter family FAM60A PF15396.6 CDI73916.1 - 0.75 9.8 18.8 0.75 9.8 18.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 CDI73916.1 - 0.77 8.5 30.7 0.82 8.4 30.7 1.1 1 0 0 1 1 1 0 Presenilin SARAF PF06682.12 CDI73916.1 - 0.8 9.3 22.0 0.84 9.2 22.0 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis O-antigen_lig PF13425.6 CDI73916.1 - 0.88 8.3 13.2 0.96 8.2 13.2 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Peptidase_S15 PF02129.18 CDI73916.1 - 0.9 9.1 21.2 1 8.9 21.2 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) eIF-3_zeta PF05091.12 CDI73916.1 - 1.1 8.2 33.2 1.1 8.2 33.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RR_TM4-6 PF06459.12 CDI73916.1 - 1.2 8.9 25.7 1.2 8.9 25.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4446 PF14584.6 CDI73916.1 - 1.3 9.0 11.0 1.5 8.8 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) CPSF100_C PF13299.6 CDI73916.1 - 1.5 9.0 22.1 1.7 8.8 22.1 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Serinc PF03348.15 CDI73916.1 - 1.6 7.6 16.3 1.6 7.6 16.3 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) FAM176 PF14851.6 CDI73916.1 - 1.6 8.4 14.8 2.4 7.8 14.8 1.4 1 0 0 1 1 1 0 FAM176 family DUF4746 PF15928.5 CDI73916.1 - 1.9 7.8 17.4 1.8 7.9 17.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DDHD PF02862.17 CDI73916.1 - 1.9 8.6 22.4 2.2 8.4 22.4 1.2 1 0 0 1 1 1 0 DDHD domain HemX PF04375.14 CDI73916.1 - 2 7.6 52.4 2.3 7.4 52.4 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase G6B PF15096.6 CDI73916.1 - 2.1 8.1 5.2 2.4 7.9 5.2 1.1 1 0 0 1 1 1 0 G6B family SpoIIP PF07454.11 CDI73916.1 - 2.4 7.5 27.5 2.7 7.4 27.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PMSI1 PF15322.6 CDI73916.1 - 2.4 7.5 19.1 2.7 7.4 19.1 1.0 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative SLC12 PF03522.15 CDI73916.1 - 2.5 7.0 24.4 2.5 7.0 24.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Nop53 PF07767.11 CDI73916.1 - 2.8 7.3 33.3 2.6 7.3 33.3 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PA26 PF04636.13 CDI73916.1 - 3.2 6.6 17.4 3.3 6.5 17.4 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Pal1 PF08316.11 CDI73916.1 - 3.3 8.5 15.5 3.5 8.4 15.5 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein CLN3 PF02487.17 CDI73916.1 - 3.4 6.6 19.2 3.5 6.6 19.2 1.1 1 0 0 1 1 1 0 CLN3 protein Endostatin PF06482.11 CDI73916.1 - 3.5 7.0 23.1 3.4 7.1 23.1 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Miga PF10265.9 CDI73916.1 - 3.6 6.4 16.4 4 6.3 16.4 1.0 1 0 0 1 1 1 0 Mitoguardin Herpes_glycop PF01528.16 CDI73916.1 - 3.7 6.3 6.3 4.3 6.1 6.3 1.2 1 0 0 1 1 1 0 Herpesvirus glycoprotein M GNAT_acetyltr_2 PF13718.6 CDI73916.1 - 3.7 6.9 15.1 4.5 6.6 15.1 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Connexin PF00029.19 CDI73916.1 - 4.1 7.1 20.8 4.7 6.9 20.8 1.1 1 0 0 1 1 1 0 Connexin Neur_chan_memb PF02932.16 CDI73916.1 - 4.3 7.3 19.4 4.3 7.3 19.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Exonuc_VII_L PF02601.15 CDI73916.1 - 4.4 6.8 30.7 5.3 6.5 30.7 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_U57 PF05582.12 CDI73916.1 - 4.8 6.4 16.8 4.9 6.3 16.8 1.1 1 0 0 1 1 1 0 YabG peptidase U57 V_ATPase_I PF01496.19 CDI73916.1 - 4.8 5.0 27.7 4.9 5.0 27.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 CDI73916.1 - 5.2 5.2 22.5 5.8 5.1 22.5 1.1 1 0 0 1 1 1 0 CDC45-like protein BORG_CEP PF14957.6 CDI73916.1 - 5.3 8.2 16.6 5.6 8.1 16.6 1.1 1 0 0 1 1 1 0 Cdc42 effector PPL5 PF18168.1 CDI73916.1 - 5.9 6.1 18.3 6 6.1 18.3 1.1 1 0 0 1 1 1 0 Prim-pol family 5 RPOL_N PF14700.6 CDI73916.1 - 6.1 6.1 31.5 6.9 6.0 31.5 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal PvlArgDC PF01862.16 CDI73916.1 - 7.1 6.4 9.2 8.7 6.1 9.2 1.1 1 0 0 1 1 1 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) VIR_N PF15912.5 CDI73916.1 - 7.5 6.1 15.9 7.4 6.1 15.9 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal NPR3 PF03666.13 CDI73916.1 - 7.5 5.2 26.8 8.4 5.1 26.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Paf1 PF03985.13 CDI73916.1 - 7.7 5.4 29.6 8.2 5.3 29.6 1.0 1 0 0 1 1 1 0 Paf1 Velvet PF11754.8 CDI73916.1 - 7.7 6.4 25.0 7.9 6.3 25.0 1.1 1 0 0 1 1 1 0 Velvet factor DUF913 PF06025.12 CDI73916.1 - 7.9 5.3 19.5 8.2 5.3 19.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NARP1 PF12569.8 CDI73916.1 - 8 5.2 25.2 8.3 5.2 25.2 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Folate_carrier PF01770.18 CDI73916.1 - 8.1 5.1 13.3 10 4.8 13.3 1.3 1 0 0 1 1 1 0 Reduced folate carrier NEMP PF10225.9 CDI73916.1 - 9.3 5.8 11.3 11 5.6 11.3 1.1 1 0 0 1 1 1 0 NEMP family YABBY PF04690.13 CDI73916.1 - 9.9 6.7 19.5 11 6.6 19.5 1.2 1 0 0 1 1 1 0 YABBY protein Kelch_1 PF01344.25 CDI73917.1 - 2.2e-18 65.5 0.0 2.2e-09 36.8 0.0 3.0 2 0 0 2 2 2 2 Kelch motif BTB PF00651.31 CDI73917.1 - 1.8e-13 50.7 0.0 3.7e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.15 CDI73917.1 - 3.2e-13 49.1 0.1 4.4e-07 29.6 0.1 3.0 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 CDI73917.1 - 2.3e-11 43.7 9.2 2.2e-06 27.8 0.0 4.8 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI73917.1 - 4.3e-11 42.6 0.0 0.00011 22.1 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 CDI73917.1 - 5.4e-11 42.4 0.1 0.00023 21.3 0.0 2.9 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 CDI73917.1 - 4.9e-10 39.3 0.1 0.00029 20.8 0.0 2.8 2 0 0 2 2 2 2 Galactose oxidase, central domain SPX PF03105.19 CDI73917.1 - 6.9 6.5 29.1 5 6.9 2.7 2.2 2 0 0 2 2 2 0 SPX domain Cript PF10235.9 CDI73918.1 - 3.9e-15 56.2 7.0 3.9e-15 56.2 7.0 1.7 1 1 1 2 2 2 1 Microtubule-associated protein CRIPT DZR PF12773.7 CDI73918.1 - 0.01 15.8 6.9 0.07 13.2 3.5 2.3 1 1 1 2 2 2 0 Double zinc ribbon zinc_ribbon_15 PF17032.5 CDI73918.1 - 0.053 14.3 8.1 0.073 13.8 4.2 2.5 2 1 0 2 2 2 0 zinc-ribbon family zf-FCS PF06467.14 CDI73918.1 - 0.37 10.8 0.3 0.37 10.8 0.3 2.9 2 1 1 3 3 3 0 MYM-type Zinc finger with FCS sequence motif C6_DPF PF10170.9 CDI73918.1 - 0.51 10.8 6.6 1.4 9.4 6.6 2.0 1 1 0 1 1 1 0 Cysteine-rich domain Sar8_2 PF03058.14 CDI73918.1 - 2 9.0 13.1 29 5.3 13.1 2.2 1 1 0 1 1 1 0 Sar8.2 family DiS_P_DiS PF06750.13 CDI73918.1 - 2.4 8.3 9.5 1.5 9.0 5.1 2.5 2 1 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain PAT1 PF09770.9 CDI73920.1 - 0.26 9.5 57.3 0.0026 16.2 47.7 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 adh_short PF00106.25 CDI73924.1 - 6.8e-31 107.2 2.9 2.3e-19 69.6 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CDI73924.1 - 1.1e-14 54.6 1.0 7.3e-09 35.5 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDI73924.1 - 1.7e-10 41.1 1.1 5.8e-08 32.8 1.1 2.2 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 CDI73924.1 - 0.0083 15.5 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CDI73924.1 - 0.014 14.9 0.2 0.22 11.0 0.1 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DFP PF04127.15 CDI73924.1 - 0.021 14.7 1.2 0.29 11.0 0.6 2.5 2 2 1 3 3 3 0 DNA / pantothenate metabolism flavoprotein DUF4607 PF15380.6 CDI73924.1 - 0.031 13.8 0.0 0.042 13.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4607) Polysacc_synt_2 PF02719.15 CDI73924.1 - 0.07 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ExoD PF06055.12 CDI73924.1 - 0.088 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Exopolysaccharide synthesis, ExoD LRR_8 PF13855.6 CDI73925.1 - 1.2e-08 34.6 3.2 0.00013 21.7 0.0 3.4 4 0 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 CDI73925.1 - 3.1e-07 30.6 1.7 0.18 12.3 0.0 5.4 5 2 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDI73925.1 - 2.3e-05 24.1 2.1 3.7 7.8 0.0 6.4 8 0 0 8 8 8 2 Leucine Rich repeat ATP-synt_E PF05680.12 CDI73925.1 - 0.074 13.4 0.1 0.15 12.4 0.1 1.4 1 0 0 1 1 1 0 ATP synthase E chain Na_K-ATPase PF00287.18 CDI73925.1 - 0.72 9.0 3.2 1 8.5 3.2 1.1 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain Mcl1_mid PF12341.8 CDI73926.1 - 2e-18 66.8 0.0 4.2e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region Acid_PPase PF12689.7 CDI73927.1 - 0.071 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Acid Phosphatase Kri1_C PF12936.7 CDI73927.1 - 0.087 13.0 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 KRI1-like family C-terminal SART-1 PF03343.13 CDI73928.1 - 0.0023 16.6 0.4 0.0023 16.6 0.4 2.3 1 1 1 2 2 2 1 SART-1 family SUIM_assoc PF16619.5 CDI73928.1 - 0.022 14.8 6.3 0.022 14.8 6.3 5.6 5 1 0 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 Sin_N PF04801.13 CDI73928.1 - 0.51 9.5 24.1 0.61 9.2 8.1 2.3 2 0 0 2 2 2 0 Sin-like protein conserved region RskA PF10099.9 CDI73929.1 - 0.01 16.1 8.1 0.013 15.8 8.1 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI73929.1 - 0.031 13.2 26.7 0.042 12.8 26.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI73929.1 - 0.032 14.2 33.1 0.036 14.1 33.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ALG3 PF05208.13 CDI73929.1 - 0.083 12.3 4.5 0.099 12.0 4.5 1.1 1 0 0 1 1 1 0 ALG3 protein ABC2_membrane_2 PF12679.7 CDI73929.1 - 0.1 11.9 4.3 0.11 11.7 4.3 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF3506 PF12014.8 CDI73929.1 - 0.14 12.2 4.8 0.2 11.6 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3506) OAD_gamma PF04277.13 CDI73929.1 - 0.18 12.4 1.6 0.32 11.6 0.1 1.9 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain YfhO PF09586.10 CDI73929.1 - 0.19 9.9 9.6 0.19 9.9 9.6 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Dpy19 PF10034.9 CDI73929.1 - 0.2 9.8 5.8 0.24 9.5 5.8 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation DUF979 PF06166.12 CDI73929.1 - 0.22 10.7 0.2 0.31 10.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF979) O-antigen_lig PF13425.6 CDI73929.1 - 0.23 10.2 2.2 0.25 10.1 2.2 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein MPM1 PF17234.2 CDI73929.1 - 0.26 11.5 17.4 0.36 11.1 17.4 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Mem_trans PF03547.18 CDI73929.1 - 0.26 9.6 5.5 0.28 9.5 5.5 1.0 1 0 0 1 1 1 0 Membrane transport protein V_ATPase_I PF01496.19 CDI73929.1 - 0.29 9.0 12.8 0.31 8.9 12.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Arv1 PF04161.13 CDI73929.1 - 0.35 11.0 4.5 0.38 10.9 4.5 1.2 1 0 0 1 1 1 0 Arv1-like family PepSY_TM PF03929.16 CDI73929.1 - 0.35 10.5 5.2 0.36 10.4 5.2 1.2 1 0 0 1 1 1 0 PepSY-associated TM region SID-1_RNA_chan PF13965.6 CDI73929.1 - 0.38 9.1 3.0 0.38 9.1 3.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Scs3p PF10261.9 CDI73929.1 - 0.41 10.1 3.6 0.58 9.6 3.6 1.4 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM PIG-U PF06728.13 CDI73929.1 - 0.42 9.6 3.0 0.52 9.3 3.0 1.2 1 0 0 1 1 1 0 GPI transamidase subunit PIG-U SLC12 PF03522.15 CDI73929.1 - 0.45 9.5 15.8 0.49 9.4 15.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 OATP PF03137.20 CDI73929.1 - 0.5 8.6 4.2 0.59 8.4 4.2 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family eIF-3_zeta PF05091.12 CDI73929.1 - 0.5 9.3 16.1 0.62 9.0 16.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Neur_chan_memb PF02932.16 CDI73929.1 - 0.55 10.3 6.5 0.63 10.0 6.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2828 PF11443.8 CDI73929.1 - 0.55 8.3 12.8 0.55 8.2 12.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Serinc PF03348.15 CDI73929.1 - 0.65 8.9 3.3 0.71 8.7 3.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF3332 PF11810.8 CDI73929.1 - 0.65 9.6 4.9 0.72 9.5 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) GRP PF07172.11 CDI73929.1 - 0.67 10.7 6.0 0.26 12.0 2.9 1.8 1 1 1 2 2 2 0 Glycine rich protein family PigN PF04987.14 CDI73929.1 - 0.74 8.6 8.1 1.1 8.1 8.1 1.3 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) CSG2 PF16965.5 CDI73929.1 - 0.78 8.6 4.5 0.81 8.6 4.5 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator MAT1 PF06391.13 CDI73929.1 - 1.3 8.8 28.6 1.9 8.2 28.6 1.3 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 FliP PF00813.20 CDI73929.1 - 1.4 8.8 6.5 1.6 8.6 6.5 1.1 1 0 0 1 1 1 0 FliP family Med15 PF09606.10 CDI73929.1 - 1.5 7.5 30.9 1.7 7.3 30.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Presenilin PF01080.17 CDI73929.1 - 2.3 6.9 17.6 2.7 6.7 17.6 1.1 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 CDI73929.1 - 2.3 7.9 12.8 3.6 7.2 12.8 1.3 1 1 0 1 1 1 0 FAM176 family UPF0560 PF10577.9 CDI73929.1 - 3.4 6.1 18.3 3.9 5.9 18.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 FAM150 PF15129.6 CDI73929.1 - 3.5 7.8 17.8 1.2 9.3 14.9 1.7 1 1 1 2 2 2 0 FAM150 family ALMT PF11744.8 CDI73929.1 - 3.8 6.2 13.2 3.8 6.2 13.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter YABBY PF04690.13 CDI73929.1 - 4 8.0 12.5 4.9 7.7 12.5 1.3 1 0 0 1 1 1 0 YABBY protein Herpes_DNAp_acc PF04929.12 CDI73929.1 - 4.5 6.2 12.6 6.8 5.5 12.6 1.4 1 1 0 1 1 1 0 Herpes DNA replication accessory factor O-antigen_lig PF13425.6 CDI73930.1 - 0.048 12.4 0.7 0.06 12.1 0.7 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein TFIIA PF03153.13 CDI73930.1 - 0.36 10.8 45.2 0.52 10.2 45.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI73930.1 - 0.46 10.4 21.3 0.56 10.1 21.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) GREB1 PF15782.5 CDI73930.1 - 2.8 4.9 26.6 3.3 4.7 26.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer VIR_N PF15912.5 CDI73930.1 - 6.3 6.3 11.0 7.9 6.0 11.0 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal Abhydrolase_9_N PF15420.6 CDI73930.1 - 8.3 6.4 14.1 11 5.9 14.1 1.2 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus Caldesmon PF02029.15 CDI73931.1 - 0.0012 17.7 22.9 0.0015 17.4 22.9 1.2 1 0 0 1 1 1 1 Caldesmon CDC45 PF02724.14 CDI73931.1 - 0.25 9.6 24.9 0.5 8.6 24.9 1.4 1 0 0 1 1 1 0 CDC45-like protein XAP5 PF04921.14 CDI73931.1 - 1.5 8.6 28.4 0.55 10.0 17.6 2.4 2 0 0 2 2 2 0 XAP5, circadian clock regulator Otopetrin PF03189.13 CDI73931.1 - 2.2 7.0 16.5 3.3 6.4 16.5 1.4 1 0 0 1 1 1 0 Otopetrin MCM3AP_GANP PF16769.5 CDI73931.1 - 9.4 4.3 36.1 13 3.8 36.1 1.1 1 0 0 1 1 1 0 MCM3AP domain of GANP HCO3_cotransp PF00955.21 CDI73932.1 - 0.00062 18.7 2.3 0.00067 18.6 2.3 1.1 1 0 0 1 1 1 1 HCO3- transporter family Presenilin PF01080.17 CDI73932.1 - 0.0016 17.3 19.3 0.0018 17.1 19.3 1.1 1 0 0 1 1 1 1 Presenilin Peroxin-3 PF04882.12 CDI73932.1 - 0.0018 17.4 10.1 0.0019 17.3 10.1 1.1 1 0 0 1 1 1 1 Peroxin-3 DUF740 PF05340.12 CDI73932.1 - 0.082 11.6 6.2 0.1 11.3 6.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF740) V_ATPase_I PF01496.19 CDI73932.1 - 0.13 10.1 18.7 0.16 9.8 18.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Neur_chan_memb PF02932.16 CDI73932.1 - 0.17 11.9 12.2 0.23 11.5 12.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ECM1 PF05782.11 CDI73932.1 - 0.31 9.9 21.1 0.36 9.7 21.1 1.0 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) ALMT PF11744.8 CDI73932.1 - 0.32 9.8 11.0 0.39 9.5 11.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SID-1_RNA_chan PF13965.6 CDI73932.1 - 0.34 9.3 5.2 0.37 9.1 5.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 LAP1C PF05609.12 CDI73932.1 - 0.42 9.7 17.7 0.51 9.4 17.7 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) TFIIA PF03153.13 CDI73932.1 - 0.43 10.5 47.0 0.57 10.1 47.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Raftlin PF15250.6 CDI73932.1 - 0.69 8.6 15.2 0.81 8.4 15.2 1.0 1 0 0 1 1 1 0 Raftlin SLC12 PF03522.15 CDI73932.1 - 0.85 8.6 19.2 0.99 8.4 19.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Membralin PF09746.9 CDI73932.1 - 1.3 8.0 10.0 1.4 7.9 10.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein Orf78 PF06024.12 CDI73932.1 - 1.5 9.2 17.1 36 4.7 17.1 2.6 1 1 0 1 1 1 0 Orf78 (ac78) Hamartin PF04388.12 CDI73932.1 - 1.6 7.3 17.3 1.9 7.1 17.3 1.0 1 0 0 1 1 1 0 Hamartin protein CDC45 PF02724.14 CDI73932.1 - 1.9 6.7 14.8 2.4 6.3 14.8 1.2 1 0 0 1 1 1 0 CDC45-like protein VIT1 PF01988.19 CDI73932.1 - 2.2 8.1 10.0 3.3 7.5 10.0 1.2 1 0 0 1 1 1 0 VIT family CSG2 PF16965.5 CDI73932.1 - 2.6 6.9 12.0 3.7 6.4 12.0 1.4 1 1 0 1 1 1 0 Ceramide synthase regulator Zip PF02535.22 CDI73932.1 - 2.8 7.1 16.8 3.6 6.7 16.7 1.3 1 1 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 CDI73932.1 - 3.4 6.3 18.7 4.3 6.0 18.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RIFIN PF02009.16 CDI73932.1 - 3.4 7.5 15.3 4.3 7.1 15.3 1.2 1 0 0 1 1 1 0 Rifin Ribosomal_60s PF00428.19 CDI73932.1 - 3.8 8.2 16.3 7.4 7.2 16.3 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein MAJIN PF15077.6 CDI73932.1 - 4.4 7.0 16.3 5.3 6.8 16.3 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein Dsh_C PF12316.8 CDI73932.1 - 4.8 7.5 15.5 5.5 7.3 15.5 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Kei1 PF08552.11 CDI73932.1 - 4.8 7.0 20.8 0.019 14.9 6.4 2.0 1 1 1 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 PBP1_TM PF14812.6 CDI73932.1 - 4.8 7.6 9.6 0.16 12.4 2.5 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal eIF-3_zeta PF05091.12 CDI73932.1 - 5.6 5.8 28.5 7 5.5 28.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM150 PF15129.6 CDI73932.1 - 5.9 7.1 17.2 40 4.4 15.5 2.2 2 0 0 2 2 2 0 FAM150 family LMBR1 PF04791.16 CDI73932.1 - 6.8 5.5 9.2 7.3 5.4 9.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Velvet PF11754.8 CDI73932.1 - 7.7 6.4 18.9 11 5.9 18.9 1.3 1 0 0 1 1 1 0 Velvet factor FPN1 PF06963.12 CDI73932.1 - 9.1 4.7 12.3 1.1 7.7 7.9 1.6 1 1 1 2 2 2 0 Ferroportin1 (FPN1) PAT1 PF09770.9 CDI73932.1 - 9.5 4.3 37.8 11 4.2 37.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 CDI73933.1 - 0.00044 20.4 1.2 0.00064 19.9 1.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region FAM60A PF15396.6 CDI73933.1 - 0.046 13.7 2.8 0.054 13.5 2.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A TAFII55_N PF04658.13 CDI73933.1 - 0.05 13.3 4.6 0.065 13.0 1.7 2.0 2 0 0 2 2 2 0 TAFII55 protein conserved region CDC45 PF02724.14 CDI73933.1 - 0.074 11.3 2.0 0.088 11.1 2.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI73933.1 - 0.11 11.2 8.1 0.13 11.0 8.1 1.3 1 0 0 1 1 1 0 Presenilin Gti1_Pac2 PF09729.9 CDI73933.1 - 0.13 12.4 3.4 0.16 12.1 3.4 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family Folliculin PF11704.8 CDI73933.1 - 0.17 11.7 4.1 0.27 11.1 4.1 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport GET2 PF08690.10 CDI73933.1 - 0.31 10.7 10.8 0.43 10.2 10.8 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 SLC12 PF03522.15 CDI73933.1 - 0.33 9.9 5.8 0.37 9.7 5.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Kei1 PF08552.11 CDI73933.1 - 0.46 10.4 3.7 0.38 10.6 2.7 1.4 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4551 PF15087.6 CDI73933.1 - 0.53 9.0 10.8 0.56 9.0 10.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CLN3 PF02487.17 CDI73933.1 - 0.55 9.2 4.2 0.72 8.8 4.2 1.1 1 0 0 1 1 1 0 CLN3 protein Lin-8 PF03353.15 CDI73933.1 - 0.61 9.6 12.2 0.73 9.3 12.2 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist ALMT PF11744.8 CDI73933.1 - 0.71 8.6 3.0 0.88 8.3 3.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Hid1 PF12722.7 CDI73933.1 - 2.6 6.0 11.1 3 5.9 11.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ndc1_Nup PF09531.10 CDI73933.1 - 5 5.7 16.1 6 5.4 16.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 CDI73933.1 - 8.2 4.6 21.6 8.6 4.5 21.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MPM1 PF17234.2 CDI73933.1 - 9.6 6.4 12.5 1.7 8.9 2.5 2.2 3 0 0 3 3 2 0 Mitochondrial peculiar membrane protein 1 UBM PF14377.6 CDI73935.1 - 1.1e-14 53.3 9.2 9e-10 37.7 1.8 11.9 13 5 1 14 14 14 3 Ubiquitin binding region DUF4746 PF15928.5 CDI73936.1 - 5.6 6.3 16.1 7.3 5.9 16.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) NDK PF00334.19 CDI73937.1 - 2.3e-17 63.3 0.0 1.6e-10 41.1 0.0 3.5 2 1 1 3 3 3 3 Nucleoside diphosphate kinase Glyco_tran_WecB PF03808.13 CDI73938.1 - 0.11 12.5 1.1 1.4 8.8 0.2 2.3 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family TFIIA PF03153.13 CDI73938.1 - 0.29 11.1 5.5 0.11 12.5 3.1 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 CDI73939.1 - 7.1 5.4 4.9 8.1 5.2 4.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain CobT PF06213.12 CDI73940.1 - 0.0045 16.4 16.2 0.0045 16.4 16.2 3.2 3 0 0 3 3 3 1 Cobalamin biosynthesis protein CobT Velvet PF11754.8 CDI73940.1 - 0.17 11.8 22.6 0.68 9.8 11.5 2.1 2 0 0 2 2 2 0 Velvet factor Spt20 PF12090.8 CDI73940.1 - 0.21 11.2 79.2 0.021 14.5 5.2 3.3 3 0 0 3 3 3 0 Spt20 family Anoctamin PF04547.12 CDI73940.1 - 0.81 8.5 5.1 1.1 8.1 5.1 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel Peroxin-3 PF04882.12 CDI73940.1 - 0.83 8.6 29.5 0.036 13.1 14.1 2.0 2 0 0 2 2 2 0 Peroxin-3 THOC2_N PF16134.5 CDI73940.1 - 1 7.9 22.7 0.93 8.0 9.6 2.1 2 0 0 2 2 2 0 THO complex subunit 2 N-terminus MID_MedPIWI PF18296.1 CDI73940.1 - 2.5 7.8 23.7 5 6.8 14.4 2.2 2 0 0 2 2 2 0 MID domain of medPIWI Pinin_SDK_memA PF04696.13 CDI73940.1 - 2.8 8.0 44.4 3.6 7.6 3.5 3.2 3 0 0 3 3 3 0 pinin/SDK/memA/ protein conserved region DUF4834 PF16118.5 CDI73940.1 - 3.1 8.8 33.8 4.1 8.4 19.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF1980 PF09323.10 CDI73940.1 - 3.2 7.6 16.1 0.29 11.0 8.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1980) PIP5K PF01504.18 CDI73940.1 - 4.4 6.5 18.2 8.4 5.5 12.6 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase U1snRNP70_N PF12220.8 CDI73940.1 - 4.4 8.0 24.2 1.1 9.9 11.2 3.2 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF5327 PF17261.2 CDI73940.1 - 9.3 7.1 39.6 2.5 8.9 18.9 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5327) GTP_EFTU PF00009.27 CDI73941.1 - 2.4e-08 33.7 0.1 7.5e-07 28.9 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDI73941.1 - 0.007 16.4 0.0 0.01 15.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase YdjO PF14169.6 CDI73941.1 - 0.12 12.1 0.3 0.21 11.3 0.3 1.4 1 0 0 1 1 1 0 Cold-inducible protein YdjO FACT-Spt16_Nlob PF14826.6 CDI73942.1 - 0.0019 18.0 0.0 0.004 17.0 0.0 1.5 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain TFIIA PF03153.13 CDI73942.1 - 1 9.3 27.2 1.5 8.7 27.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Transketolase_N PF00456.21 CDI73945.1 - 2.2e-140 467.3 0.0 3.6e-140 466.7 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CDI73945.1 - 1e-33 116.5 0.0 1.8e-33 115.7 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDI73945.1 - 6e-05 22.9 0.0 0.00016 21.6 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 CDI73945.1 - 0.00089 18.5 0.0 0.0018 17.6 0.0 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 CDI73945.1 - 0.014 14.4 0.0 0.029 13.3 0.0 1.5 1 0 0 1 1 1 0 Dehydrogenase E1 component HTH_3 PF01381.22 CDI73946.1 - 1.1e-14 54.3 0.1 1.6e-14 53.7 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix MBF1 PF08523.10 CDI73946.1 - 1.7e-14 54.0 7.2 6.3e-14 52.2 0.7 2.7 3 0 0 3 3 3 1 Multiprotein bridging factor 1 HTH_31 PF13560.6 CDI73946.1 - 2.8e-07 30.8 0.0 4.7e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CDI73946.1 - 6.3e-07 29.3 0.0 1.8e-06 27.8 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_26 PF13443.6 CDI73946.1 - 0.00034 21.0 0.0 0.0006 20.2 0.0 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_38 PF13936.6 CDI73946.1 - 0.0093 15.7 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 CDI73946.1 - 0.024 14.6 0.1 0.045 13.7 0.1 1.5 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_25 PF13413.6 CDI73946.1 - 0.047 13.5 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Dynein_light PF01221.18 CDI73948.1 - 9.7e-37 125.2 0.6 1.1e-36 125.0 0.6 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 SAWADEE PF16719.5 CDI73950.1 - 0.011 15.8 0.2 0.062 13.3 0.0 2.3 3 1 1 4 4 4 0 SAWADEE domain XRN_M PF17846.1 CDI73950.1 - 0.03 13.3 6.0 0.026 13.5 1.2 2.1 2 0 0 2 2 2 0 Xrn1 helical domain Rib_recp_KP_reg PF05104.12 CDI73950.1 - 0.17 12.9 29.7 1 10.4 19.1 2.3 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region DDHD PF02862.17 CDI73950.1 - 0.89 9.7 8.9 1.5 8.9 2.6 2.2 2 0 0 2 2 2 0 DDHD domain Velvet PF11754.8 CDI73950.1 - 4.6 7.1 10.0 3.9 7.3 5.3 2.0 2 0 0 2 2 2 0 Velvet factor Pkinase PF00069.25 CDI73951.1 - 8.9e-22 77.7 0.0 1.4e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI73951.1 - 5e-12 45.7 0.0 9.2e-12 44.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI73951.1 - 2.4e-07 29.9 0.0 3.4e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDI73951.1 - 4.1e-05 23.6 10.2 0.0042 17.0 0.1 3.8 4 0 0 4 4 4 2 Phosphotransferase enzyme family Kdo PF06293.14 CDI73951.1 - 0.0061 15.9 0.1 0.018 14.4 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PepSY_2 PF13670.6 CDI73951.1 - 4.1 7.5 8.4 28 4.8 8.4 2.3 1 1 0 1 1 1 0 Peptidase propeptide and YPEB domain TPR_1 PF00515.28 CDI73952.1 - 3.7e-32 108.8 15.7 4.9e-09 35.6 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 CDI73952.1 - 5.6e-26 88.5 13.0 1e-06 28.4 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat STI1 PF17830.1 CDI73952.1 - 1.1e-14 54.1 4.5 2.8e-14 52.8 4.0 2.1 2 0 0 2 2 1 1 STI1 domain TPR_11 PF13414.6 CDI73952.1 - 1.6e-14 53.3 2.7 5.6e-05 22.7 0.2 4.5 3 1 1 4 4 4 3 TPR repeat TPR_12 PF13424.6 CDI73952.1 - 1.6e-14 53.9 2.4 9.7e-09 35.4 0.2 3.9 4 1 0 4 4 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDI73952.1 - 3.3e-12 45.6 12.9 0.0023 18.0 1.3 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDI73952.1 - 1.1e-10 42.0 0.2 0.0012 19.5 0.0 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 CDI73952.1 - 6.7e-10 38.7 6.3 0.0098 16.2 0.3 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDI73952.1 - 1e-09 37.7 1.7 6.5e-05 22.7 0.2 4.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI73952.1 - 1.2e-08 35.0 0.8 1.1 10.2 0.1 5.1 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 CDI73952.1 - 1.6e-07 31.3 0.1 0.033 14.3 0.0 4.1 1 1 2 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDI73952.1 - 1.6e-06 28.5 2.3 0.47 11.0 0.0 3.8 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 CDI73952.1 - 3e-05 23.8 6.4 0.067 13.1 0.1 3.9 6 0 0 6 6 5 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDI73952.1 - 0.00034 20.6 6.4 0.71 10.0 0.0 4.6 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 CDI73952.1 - 0.0027 18.2 5.7 0.24 12.1 0.5 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat DnaI_N PF07319.11 CDI73952.1 - 0.0061 17.2 3.1 0.077 13.7 0.8 2.8 2 1 0 2 2 2 1 Primosomal protein DnaI N-terminus ANAPC3 PF12895.7 CDI73952.1 - 0.022 15.0 7.1 0.69 10.2 2.0 3.1 2 2 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DNA_pol_A_exo1 PF01612.20 CDI73952.1 - 0.04 13.6 0.0 0.074 12.8 0.0 1.5 1 0 0 1 1 1 0 3'-5' exonuclease PPR PF01535.20 CDI73952.1 - 0.2 12.0 0.9 0.58 10.5 0.2 2.3 2 0 0 2 2 1 0 PPR repeat MIT PF04212.18 CDI73952.1 - 0.41 10.8 8.0 5.9 7.1 0.8 4.1 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain SUIM_assoc PF16619.5 CDI73954.1 - 0.00073 19.5 1.3 0.00073 19.5 1.3 13.5 5 3 1 6 6 6 1 Unstructured region C-term to UIM in Ataxin3 eIF3_subunit PF08597.10 CDI73956.1 - 0.027 14.4 0.9 0.035 14.0 0.9 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Glyco_hydro_9 PF00759.19 CDI73956.1 - 2.3 7.6 8.9 2.9 7.2 8.9 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 DEAD PF00270.29 CDI73957.1 - 5.3e-15 55.6 0.0 2.3e-14 53.5 0.0 3.3 4 0 0 4 4 4 2 DEAD/DEAH box helicase Hamartin PF04388.12 CDI73957.1 - 1.7 7.2 43.6 2.8 6.5 43.6 1.3 1 0 0 1 1 1 0 Hamartin protein PAT1 PF09770.9 CDI73957.1 - 4.9 5.3 44.0 7.2 4.8 44.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ORC6 PF05460.13 CDI73957.1 - 6.9 5.8 45.0 14 4.8 45.0 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Peptidase_M28 PF04389.17 CDI73958.1 - 9.2e-16 58.1 0.6 4.8e-14 52.5 0.6 3.1 1 1 0 1 1 1 1 Peptidase family M28 Spt20 PF12090.8 CDI73958.1 - 0.0028 17.3 9.7 0.0028 17.3 9.7 3.4 3 0 0 3 3 3 2 Spt20 family DUF2371 PF10177.9 CDI73958.1 - 0.24 11.5 1.1 5.9 7.1 0.0 2.8 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) RAB3GAP2_N PF14655.6 CDI73958.1 - 2.2 7.4 10.3 1.5 8.0 2.9 2.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF2126 PF09899.9 CDI73958.1 - 4.4 5.3 8.4 0.37 8.8 3.1 1.6 1 1 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) DUF2722 PF10846.8 CDI73958.1 - 6 5.7 30.3 0.0056 15.7 7.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Activator_LAG-3 PF11498.8 CDI73961.1 - 0.00045 19.3 28.4 0.00045 19.3 28.4 15.3 6 2 9 16 16 16 3 Transcriptional activator LAG-3 RskA PF10099.9 CDI73961.1 - 0.0075 16.6 26.9 0.0075 16.6 26.9 20.8 2 2 13 15 15 15 3 Anti-sigma-K factor rskA PAM2 PF07145.15 CDI73961.1 - 0.11 12.3 0.6 0.21 11.4 0.6 1.5 1 0 0 1 1 1 0 Ataxin-2 C-terminal region N6_N4_Mtase PF01555.18 CDI73961.1 - 3.6 7.2 13.1 21 4.7 1.0 6.5 5 2 0 5 5 5 0 DNA methylase Nop14 PF04147.12 CDI73962.1 - 1.6e-05 23.4 27.9 1.6e-05 23.4 27.9 2.0 2 0 0 2 2 2 2 Nop14-like family FAM60A PF15396.6 CDI73962.1 - 0.67 9.9 36.6 0.17 11.9 6.0 2.5 2 0 0 2 2 2 0 Protein Family FAM60A SLC12 PF03522.15 CDI73962.1 - 1.7 7.6 47.7 0.11 11.5 23.5 2.1 2 0 0 2 2 2 0 Solute carrier family 12 MDM10 PF12519.8 CDI73962.1 - 4.4 6.1 32.3 3 6.6 17.7 2.4 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 NPR3 PF03666.13 CDI73962.1 - 7.6 5.2 44.4 0.17 10.6 16.6 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2151 PF10221.9 CDI73962.1 - 9 4.7 32.0 0.47 9.0 8.2 2.1 2 0 0 2 2 2 0 Cell cycle and development regulator Mpp10 PF04006.12 CDI73962.1 - 9.1 4.6 71.7 0.26 9.7 38.0 2.1 2 0 0 2 2 2 0 Mpp10 protein Brix PF04427.18 CDI73964.1 - 5.4e-28 98.4 0.1 1.1e-27 97.4 0.1 1.5 1 0 0 1 1 1 1 Brix domain Asp-B-Hydro_N PF05279.11 CDI73964.1 - 2.1 8.4 7.8 2.9 7.9 7.8 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4554 PF15091.6 CDI73964.1 - 2.7 6.8 5.3 3.7 6.3 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) SET PF00856.28 CDI73965.1 - 2.7e-08 34.4 0.0 2.7e-08 34.4 0.0 4.4 3 3 0 3 3 3 1 SET domain Mon1 PF03164.14 CDI73966.1 - 1.9e-53 182.0 0.0 5.7e-32 111.3 0.0 2.8 2 1 0 2 2 2 2 Trafficking protein Mon1 Ribosomal_60s PF00428.19 CDI73967.1 - 0.012 16.2 2.4 0.012 16.2 2.4 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein NYN_YacP PF05991.11 CDI73968.1 - 0.014 15.3 1.3 0.044 13.7 1.3 1.9 1 0 0 1 1 1 0 YacP-like NYN domain UPF0239 PF06783.11 CDI73968.1 - 0.1 12.8 5.2 0.3 11.3 5.2 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) DUF728 PF05304.12 CDI73968.1 - 0.19 11.6 1.7 0.59 10.0 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF728) Presenilin PF01080.17 CDI73968.1 - 0.21 10.3 1.7 0.4 9.4 1.7 1.5 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CDI73968.1 - 0.33 11.9 3.6 0.88 10.6 3.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Peptidase_S49_N PF08496.10 CDI73968.1 - 2.8 8.0 14.9 16 5.5 0.4 2.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal MadM PF03818.13 CDI73972.1 - 0.23 11.4 0.2 0.4 10.6 0.2 1.3 1 0 0 1 1 1 0 Malonate/sodium symporter MadM subunit DUF2439 PF10382.9 CDI73977.1 - 4.6e-05 23.7 0.0 0.00011 22.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) Dehydrin PF00257.19 CDI73978.1 - 0.01 16.4 10.0 0.01 16.4 10.0 14.7 8 5 4 13 13 13 0 Dehydrin TrmE_N PF10396.9 CDI73980.1 - 4.9e-05 23.6 0.0 4.9e-05 23.6 0.0 3.2 1 1 2 3 3 3 1 GTP-binding protein TrmE N-terminus RskA PF10099.9 CDI73980.1 - 0.022 15.1 47.8 1e+03 -0.2 0.2 3.2 2 1 0 2 2 2 0 Anti-sigma-K factor rskA CDC13_N PF16853.5 CDI73980.1 - 0.034 13.7 0.4 0.034 13.7 0.4 1.5 2 0 0 2 2 2 0 Cell division control protein 13 N-terminus DUF413 PF04219.12 CDI73980.1 - 0.077 13.0 0.4 4.2 7.5 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function, DUF Activator_LAG-3 PF11498.8 CDI73980.1 - 0.22 10.4 23.3 0.058 12.4 12.1 2.3 2 0 0 2 2 2 0 Transcriptional activator LAG-3 MlaC PF05494.12 CDI73980.1 - 0.37 10.5 8.3 0.11 12.2 4.4 2.0 2 0 0 2 2 2 0 MlaC protein DUF2232 PF09991.9 CDI73980.1 - 1 8.5 2.4 1.5 7.9 2.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) OmpH PF03938.14 CDI73980.1 - 2.7 8.3 27.8 0.48 10.8 18.0 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) TFIIA PF03153.13 CDI73980.1 - 2.9 7.8 36.8 0.61 10.0 8.0 2.0 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit Arg_decarbox_C PF17944.1 CDI73981.1 - 0.21 12.2 0.5 3.9 8.1 0.1 2.6 2 0 0 2 2 2 0 Arginine decarboxylase C-terminal helical extension Phage_TAC_7 PF10109.9 CDI73983.1 - 0.17 12.0 0.0 0.17 12.0 0.0 3.3 4 0 0 4 4 4 0 Phage tail assembly chaperone proteins, E, or 41 or 14 Cyt_bd_oxida_II PF02322.15 CDI73983.1 - 0.21 10.9 0.0 0.21 10.9 0.0 3.0 3 1 1 4 4 4 0 Cytochrome bd terminal oxidase subunit II CHDCT2 PF08074.11 CDI73983.1 - 0.23 11.6 0.0 0.23 11.6 0.0 4.8 5 1 2 7 7 7 0 CHDCT2 (NUC038) domain SUIM_assoc PF16619.5 CDI73983.1 - 0.37 10.9 0.1 0.37 10.9 0.1 7.2 4 2 1 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 SLIDE PF09111.10 CDI73983.1 - 1.6 8.7 0.0 1.6 8.7 0.0 3.3 3 0 0 3 3 3 0 SLIDE DUF3246 PF11596.8 CDI73983.1 - 3 7.2 13.4 0.036 13.5 4.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) RYDR_ITPR PF01365.21 CDI73984.1 - 0.015 14.7 1.2 0.016 14.6 1.2 1.1 1 0 0 1 1 1 0 RIH domain Spt20 PF12090.8 CDI73984.1 - 0.14 11.8 9.9 0.16 11.6 9.9 1.1 1 0 0 1 1 1 0 Spt20 family PRP38_assoc PF12871.7 CDI73985.1 - 5.4 7.7 88.0 15 6.2 76.5 2.9 1 1 1 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Sporozoite_P67 PF05642.11 CDI73987.1 - 0.72 7.9 6.2 0.73 7.9 6.2 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Herpes_capsid PF06112.11 CDI73987.1 - 2.9 7.9 15.7 3.3 7.8 15.7 1.1 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein DUF726 PF05277.12 CDI73988.1 - 0.27 10.1 6.3 0.34 9.8 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) FHA PF00498.26 CDI73989.1 - 1.3e-10 41.5 0.0 2.4e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CDI73989.1 - 1.5e-07 31.6 0.0 2.6e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain MU2_FHA PF18221.1 CDI73989.1 - 0.061 13.4 0.0 0.13 12.3 0.0 1.5 2 0 0 2 2 2 0 Mutator 2 Fork head associated domain DUF4366 PF14283.6 CDI73990.1 - 0.002 18.2 3.3 0.002 18.2 3.3 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4366) Oxidored_q3 PF00499.20 CDI73990.1 - 0.0025 17.6 1.3 0.0051 16.5 1.3 1.6 1 1 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 CAC1F_C PF16885.5 CDI73990.1 - 3.9 7.1 16.2 4.5 6.8 16.2 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term RNA_polI_A34 PF08208.11 CDI73990.1 - 6.3 6.8 29.0 0.4 10.7 17.8 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4834 PF16118.5 CDI73991.1 - 0.00021 22.2 27.1 0.0022 18.9 2.5 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) CLN3 PF02487.17 CDI73991.1 - 0.00023 20.3 2.7 0.00023 20.3 2.7 2.1 1 1 1 2 2 1 1 CLN3 protein SR-25 PF10500.9 CDI73991.1 - 0.00079 19.1 18.8 0.00079 19.1 18.8 2.3 2 0 0 2 2 1 1 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 CDI73991.1 - 0.00088 17.7 16.6 0.021 13.1 7.2 2.1 2 0 0 2 2 2 2 CDC45-like protein CTU2 PF10288.9 CDI73991.1 - 0.0011 19.2 20.1 0.011 16.0 3.7 2.5 2 0 0 2 2 2 2 Cytoplasmic tRNA 2-thiolation protein 2 TCP PF03634.13 CDI73991.1 - 0.0023 18.5 25.1 0.14 12.7 3.2 2.3 2 0 0 2 2 2 2 TCP family transcription factor SID-1_RNA_chan PF13965.6 CDI73991.1 - 0.0038 15.7 1.7 0.0038 15.7 1.7 2.1 2 0 0 2 2 2 1 dsRNA-gated channel SID-1 Shisa PF13908.6 CDI73991.1 - 0.0079 16.5 3.5 0.0079 16.5 3.5 2.6 2 1 0 2 2 1 1 Wnt and FGF inhibitory regulator Connexin PF00029.19 CDI73991.1 - 0.019 14.7 19.7 0.12 12.1 5.5 2.2 2 0 0 2 2 2 0 Connexin MecA PF05389.12 CDI73991.1 - 0.029 14.0 20.0 0.27 10.8 2.1 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) Tmemb_9 PF05434.11 CDI73991.1 - 0.036 13.9 0.6 0.036 13.9 0.6 2.8 2 1 0 2 2 1 0 TMEM9 Sporozoite_P67 PF05642.11 CDI73991.1 - 0.037 12.1 11.2 0.067 11.3 11.2 1.4 1 1 0 1 1 1 0 Sporozoite P67 surface antigen Spt20 PF12090.8 CDI73991.1 - 0.05 13.2 66.2 0.25 10.9 32.0 2.1 2 0 0 2 2 2 0 Spt20 family PA26 PF04636.13 CDI73991.1 - 0.078 11.9 24.3 0.038 12.9 2.6 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) OATP PF03137.20 CDI73991.1 - 0.082 11.2 14.7 0.23 9.7 4.8 2.2 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Neur_chan_memb PF02932.16 CDI73991.1 - 0.11 12.5 21.8 0.79 9.7 1.0 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF4820 PF16091.5 CDI73991.1 - 0.19 11.0 23.8 1.1 8.6 12.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) MID_MedPIWI PF18296.1 CDI73991.1 - 0.35 10.6 21.8 0.37 10.6 0.2 2.1 2 0 0 2 2 2 0 MID domain of medPIWI DUF4471 PF14740.6 CDI73991.1 - 0.39 9.9 14.7 0.18 11.0 1.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) PIG-P PF08510.12 CDI73991.1 - 0.68 9.9 1.9 1.1 9.2 0.0 2.0 2 0 0 2 2 2 0 PIG-P MLANA PF14991.6 CDI73991.1 - 0.8 10.0 11.9 0.82 10.0 1.0 2.4 2 0 0 2 2 2 0 Protein melan-A FAM176 PF14851.6 CDI73991.1 - 0.88 9.2 27.2 0.019 14.6 3.6 2.5 2 1 0 2 2 2 0 FAM176 family TT_ORF1 PF02956.14 CDI73991.1 - 0.92 8.1 14.3 0.53 8.9 2.2 2.0 2 0 0 2 2 2 0 TT viral orf 1 DAG_kinase_N PF14513.6 CDI73991.1 - 1.1 9.5 24.4 0.36 11.0 1.3 2.3 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus SLC12 PF03522.15 CDI73991.1 - 1.1 8.2 26.4 0.1 11.6 2.3 2.0 2 0 0 2 2 2 0 Solute carrier family 12 Comm PF15957.5 CDI73991.1 - 1.1 9.6 8.9 0.41 11.0 0.6 2.3 2 0 0 2 2 2 0 Commissureless ALMT PF11744.8 CDI73991.1 - 1.3 7.7 19.8 1.8 7.3 2.4 2.2 2 0 0 2 2 2 0 Aluminium activated malate transporter DUF1980 PF09323.10 CDI73991.1 - 1.7 8.5 19.2 0.37 10.7 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) TRAP_alpha PF03896.16 CDI73991.1 - 1.9 7.6 16.5 2.4 7.3 3.4 2.3 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF2722 PF10846.8 CDI73991.1 - 2 7.3 56.1 0.015 14.2 21.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) EOS1 PF12326.8 CDI73991.1 - 2.1 8.2 18.3 0.38 10.7 0.2 2.3 2 0 0 2 2 2 0 N-glycosylation protein Endostatin PF06482.11 CDI73991.1 - 2.5 7.5 23.9 1.5 8.2 11.0 2.1 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin CSG2 PF16965.5 CDI73991.1 - 2.8 6.8 17.7 0.59 9.0 0.6 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator MMU163 PF17119.5 CDI73991.1 - 2.9 7.0 16.5 2.5 7.2 0.9 2.2 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis Pkinase_fungal PF17667.1 CDI73991.1 - 3 6.5 13.5 0.78 8.5 4.9 2.0 2 0 0 2 2 2 0 Fungal protein kinase GAGA_bind PF06217.12 CDI73991.1 - 3.1 8.0 21.9 0.2 11.9 3.6 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family PEX11 PF05648.14 CDI73991.1 - 3.4 7.1 14.5 0.41 10.1 1.9 2.5 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) DUF913 PF06025.12 CDI73991.1 - 3.7 6.4 23.1 1.1 8.2 3.1 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) MMM1 PF10296.9 CDI73991.1 - 3.7 6.5 21.6 0.62 9.1 4.1 2.1 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 AAR2 PF05282.11 CDI73991.1 - 4.4 6.6 17.8 2.5 7.4 0.6 2.1 2 0 0 2 2 2 0 AAR2 protein RuvC_III PF18541.1 CDI73991.1 - 5.2 7.0 19.1 7.8 6.4 6.4 2.4 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 Band_3_cyto PF07565.13 CDI73991.1 - 5.2 6.8 29.7 0.31 10.8 11.7 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain U1snRNP70_N PF12220.8 CDI73991.1 - 8 7.2 29.4 1.1 9.9 6.3 2.7 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RICTOR_N PF14664.6 CDI73991.1 - 8.3 5.3 17.6 0.73 8.8 2.1 2.1 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term FAM91_C PF14648.6 CDI73991.1 - 8.8 5.0 14.1 5 5.9 4.2 2.1 2 0 0 2 2 2 0 FAM91 C-terminus DUF1645 PF07816.11 CDI73992.1 - 6.1e-06 27.0 1.5 6.1e-06 27.0 1.5 6.7 3 2 1 4 4 4 2 Protein of unknown function (DUF1645) Spt20 PF12090.8 CDI73992.1 - 0.00022 20.9 1.3 0.00022 20.9 1.3 5.8 5 2 0 5 5 5 1 Spt20 family SR-25 PF10500.9 CDI73992.1 - 0.00042 20.0 5.4 0.00042 20.0 5.4 7.3 6 1 0 7 7 7 1 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI73992.1 - 0.00072 19.9 5.0 0.012 15.9 0.4 5.4 3 2 3 6 6 6 2 Anti-sigma-K factor rskA Utp14 PF04615.13 CDI73992.1 - 0.0014 17.4 3.5 0.0014 17.4 3.5 3.5 2 1 0 2 2 2 1 Utp14 protein DUF2722 PF10846.8 CDI73992.1 - 0.0046 16.0 3.6 0.0046 16.0 3.6 6.9 4 3 1 6 6 6 1 Protein of unknown function (DUF2722) DUF4667 PF15700.5 CDI73992.1 - 0.015 15.4 3.5 0.015 15.4 3.5 6.0 5 1 0 5 5 5 0 Domain of unknown function (DUF4667) DNMT1-RFD PF12047.8 CDI73994.1 - 1.1e-06 28.7 0.0 4.6e-06 26.7 0.0 2.1 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain RskA PF10099.9 CDI73994.1 - 0.0019 18.5 0.0 0.0019 18.5 0.0 27.0 5 5 12 17 17 17 2 Anti-sigma-K factor rskA PBP1_TM PF14812.6 CDI73995.1 - 0.032 14.6 3.1 0.032 14.6 3.1 3.1 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4689 PF15755.5 CDI73996.1 - 0.031 13.9 2.6 0.039 13.6 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4689) ATG2_CAD PF13329.6 CDI73996.1 - 0.052 13.3 0.6 0.063 13.0 0.6 1.1 1 0 0 1 1 1 0 Autophagy-related protein 2 CAD motif Pex14_N PF04695.13 CDI73996.1 - 0.5 11.0 14.3 0.62 10.7 14.3 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MAJIN PF15077.6 CDI73996.1 - 0.78 9.5 5.7 0.87 9.3 5.7 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein TFIIA PF03153.13 CDI73996.1 - 1.1 9.2 24.3 1.2 9.0 24.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 CDI73996.1 - 2.9 6.8 12.6 3.5 6.5 12.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AIF_C PF14721.6 CDI73996.1 - 4.7 7.6 8.3 5.4 7.4 7.6 1.4 1 1 1 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Presenilin PF01080.17 CDI73996.1 - 7.3 5.2 8.7 7.5 5.2 8.7 1.0 1 0 0 1 1 1 0 Presenilin PP2C PF00481.21 CDI73997.1 - 0.0099 15.5 0.0 0.012 15.3 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C DUF3138 PF11336.8 CDI73997.1 - 0.041 12.5 4.1 0.064 11.9 4.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) 5_nucleotid_C PF02872.18 CDI73998.1 - 1.6e-37 129.1 0.0 4.8e-37 127.6 0.0 1.8 2 0 0 2 2 2 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CDI73998.1 - 8.3e-06 26.4 0.9 9.6e-05 23.0 0.9 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase F-box-like PF12937.7 CDI73999.1 - 0.01 15.7 0.9 0.01 15.7 0.9 2.6 3 0 0 3 3 3 0 F-box-like F-box PF00646.33 CDI73999.1 - 0.041 13.8 1.6 0.15 11.9 1.6 2.0 1 0 0 1 1 1 0 F-box domain FapA PF03961.13 CDI73999.1 - 0.055 12.1 1.5 0.094 11.3 1.5 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Cbl_N PF02262.16 CDI73999.1 - 0.2 11.7 2.0 3.9 7.5 1.6 2.7 2 0 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 SUIM_assoc PF16619.5 CDI73999.1 - 0.34 11.0 9.6 5.3 7.2 1.8 4.4 4 1 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 DUF2203 PF09969.9 CDI73999.1 - 3 8.6 6.8 3 8.6 1.5 3.4 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) Not3 PF04065.15 CDI73999.1 - 4 6.8 9.7 8.3 5.8 9.7 1.4 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component FA_desaturase PF00487.24 CDI74000.1 - 1.9e-09 37.7 16.0 1.9e-09 37.7 16.0 3.6 3 2 1 4 4 4 2 Fatty acid desaturase DUF569 PF04601.13 CDI74000.1 - 0.11 12.2 0.2 0.19 11.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF569) OST3_OST6 PF04756.13 CDI74001.1 - 2.3e-15 56.7 0.0 1.9e-10 40.6 0.0 2.2 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Fcf1 PF04900.12 CDI74002.1 - 3.3e-33 114.0 2.0 3.3e-33 114.0 2.0 1.9 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 CDI74002.1 - 4.2e-14 52.8 0.7 7.8e-14 52.0 0.1 1.8 2 0 0 2 2 2 1 PIN like domain SID-1_RNA_chan PF13965.6 CDI74002.1 - 0.072 11.5 0.0 0.13 10.7 0.0 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PKcGMP_CC PF16808.5 CDI74003.1 - 0.23 11.4 6.9 8.7 6.3 0.1 3.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FAM76 PF16046.5 CDI74003.1 - 0.76 9.1 15.7 2.3 7.5 1.4 2.2 2 0 0 2 2 2 0 FAM76 protein ATG16 PF08614.11 CDI74003.1 - 1.5 9.0 29.7 2.1 8.5 2.5 2.6 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF4201 PF13870.6 CDI74003.1 - 2.3 7.9 24.8 3.9 7.2 1.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) Spc7 PF08317.11 CDI74003.1 - 3.6 6.4 22.0 4.9 5.9 1.1 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein UPF0242 PF06785.11 CDI74003.1 - 4.6 7.3 24.4 20 5.2 18.6 2.8 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 CDI74003.1 - 7.2 5.6 16.1 3.2 6.8 0.2 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF745 PF05335.13 CDI74003.1 - 7.3 6.3 22.1 0.47 10.1 7.8 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF745) DUF3972 PF13118.6 CDI74003.1 - 9.1 6.7 14.1 1.4 9.3 4.8 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3972) Nop53 PF07767.11 CDI74004.1 - 0.11 11.8 45.7 0.14 11.6 45.7 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF572 PF04502.13 CDI74004.1 - 4.8 6.7 38.5 6.4 6.3 38.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) LAP1C PF05609.12 CDI74004.1 - 6.9 5.6 50.5 8.3 5.4 50.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Hamartin PF04388.12 CDI74004.1 - 8.3 4.9 48.5 9.7 4.7 48.5 1.1 1 0 0 1 1 1 0 Hamartin protein PRAS PF15798.5 CDI74005.1 - 0.047 14.3 0.1 0.047 14.3 0.1 3.0 3 0 0 3 3 3 0 Proline-rich AKT1 substrate 1 Fungal_lectin_2 PF18647.1 CDI74005.1 - 0.43 11.1 7.5 0.77 10.2 1.0 3.0 3 0 0 3 3 3 0 Alpha-galactosyl-binding fungal lectin DUF4058 PF13267.6 CDI74005.1 - 1.8 7.9 6.8 0.17 11.3 1.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4058) Lin-8 PF03353.15 CDI74005.1 - 5.1 6.6 19.8 0.11 12.0 12.2 1.9 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Neur_chan_memb PF02932.16 CDI74005.1 - 5.6 6.9 12.7 0.79 9.7 7.1 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DEAD PF00270.29 CDI74006.1 - 4.5e-16 59.1 4.4 3.3e-10 40.0 3.8 6.4 6 1 0 6 6 6 2 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI74006.1 - 0.00022 21.6 0.0 0.00022 21.6 0.0 5.9 6 1 0 6 6 6 1 Helicase conserved C-terminal domain RskA PF10099.9 CDI74006.1 - 0.00035 20.9 1.6 0.00035 20.9 1.6 13.8 3 2 9 12 12 12 4 Anti-sigma-K factor rskA SDA1 PF05285.12 CDI74006.1 - 0.0011 18.5 12.1 0.0011 18.5 12.1 7.4 4 3 3 7 7 7 2 SDA1 Spt20 PF12090.8 CDI74006.1 - 0.0016 18.1 15.8 0.0016 18.1 15.8 12.8 9 2 2 11 11 11 4 Spt20 family K_channel_TID PF07941.11 CDI74008.1 - 0.0056 17.1 16.3 0.0056 17.1 16.3 8.7 6 3 1 7 7 7 1 Potassium channel Kv1.4 tandem inactivation domain RskA PF10099.9 CDI74008.1 - 0.017 15.4 13.3 0.017 15.4 13.3 6.0 3 2 1 4 4 4 0 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI74010.1 - 1.3 8.6 28.7 0.35 10.5 4.1 3.3 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein MPM1 PF17234.2 CDI74010.1 - 6.7 6.9 10.2 8.2 6.7 2.6 2.4 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 CSG2 PF16965.5 CDI74011.1 - 0.058 12.3 8.4 0.49 9.3 0.5 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator Presenilin PF01080.17 CDI74011.1 - 0.18 10.5 12.5 0.028 13.2 3.5 2.2 2 0 0 2 2 2 0 Presenilin Connexin PF00029.19 CDI74011.1 - 0.31 10.8 2.9 0.52 10.0 0.9 2.0 2 0 0 2 2 2 0 Connexin RIFIN PF02009.16 CDI74011.1 - 0.83 9.5 14.1 0.1 12.5 4.7 2.2 2 0 0 2 2 2 0 Rifin eIF-3_zeta PF05091.12 CDI74011.1 - 0.92 8.4 11.1 0.039 12.9 4.7 1.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Neur_chan_memb PF02932.16 CDI74011.1 - 1.9 8.5 12.1 1.3 9.0 2.5 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region BORG_CEP PF14957.6 CDI74011.1 - 2.5 9.3 12.3 2.1 9.5 1.8 2.5 2 0 0 2 2 2 0 Cdc42 effector Lin-8 PF03353.15 CDI74011.1 - 3.1 7.3 23.6 0.077 12.5 4.2 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist EphA2_TM PF14575.6 CDI74011.1 - 3.7 8.5 7.2 50 4.9 4.2 2.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain MecA PF05389.12 CDI74011.1 - 6.2 6.4 10.8 0.21 11.2 1.7 2.2 2 1 0 2 2 2 0 Negative regulator of genetic competence (MecA) Dehydrin PF00257.19 CDI74012.1 - 0.0011 19.5 1.8 0.0011 19.5 1.8 13.9 8 5 2 10 10 10 1 Dehydrin Methyltransf_5 PF01795.19 CDI74013.1 - 2.3e-30 106.2 0.3 3.3e-17 63.0 0.7 2.6 2 0 0 2 2 2 2 MraW methylase family DDHD PF02862.17 CDI74013.1 - 3.3e-05 24.2 6.6 0.00049 20.3 0.8 2.3 2 0 0 2 2 2 1 DDHD domain Gti1_Pac2 PF09729.9 CDI74013.1 - 0.0019 18.3 0.8 0.0019 18.3 0.8 2.4 2 1 0 2 2 1 1 Gti1/Pac2 family GramPos_pilinD1 PF16555.5 CDI74013.1 - 0.003 17.7 4.0 0.46 10.6 4.2 2.3 2 0 0 2 2 2 1 Gram-positive pilin subunit D1, N-terminal domain TERB2 PF15101.6 CDI74013.1 - 0.0055 16.8 23.7 0.0073 16.4 12.5 2.3 2 0 0 2 2 2 1 Telomere-associated protein TERB2 SpoIIP PF07454.11 CDI74013.1 - 0.0079 15.7 10.1 0.0079 15.7 10.1 2.1 2 0 0 2 2 2 1 Stage II sporulation protein P (SpoIIP) CCSAP PF15748.5 CDI74013.1 - 0.01 16.0 24.0 0.052 13.7 1.1 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated AF-4 PF05110.13 CDI74013.1 - 0.03 12.4 28.0 0.086 10.9 8.2 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein DUF3347 PF11827.8 CDI74013.1 - 0.032 14.4 15.4 0.77 9.9 12.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) DUF913 PF06025.12 CDI74013.1 - 0.045 12.7 10.9 0.12 11.3 6.3 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Eapp_C PF10238.9 CDI74013.1 - 0.046 13.8 23.4 0.062 13.4 15.3 2.6 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF4638 PF15472.6 CDI74013.1 - 0.076 12.7 12.1 0.13 11.9 6.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) PRP1_N PF06424.12 CDI74013.1 - 0.087 13.2 14.7 0.26 11.7 8.8 2.2 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Velvet PF11754.8 CDI74013.1 - 0.09 12.7 16.8 1.4 8.8 0.7 2.2 2 0 0 2 2 2 0 Velvet factor eIF-3_zeta PF05091.12 CDI74013.1 - 0.1 11.6 23.1 0.26 10.2 14.8 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rxt3 PF08642.10 CDI74013.1 - 0.1 13.4 8.8 0.54 11.0 2.8 2.4 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 AFT PF08731.11 CDI74013.1 - 0.11 12.9 10.6 0.41 11.1 7.5 2.3 2 0 0 2 2 2 0 Transcription factor AFT PTPRCAP PF15713.5 CDI74013.1 - 0.11 12.8 21.7 0.044 14.1 13.6 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Peroxin-13_N PF04088.13 CDI74013.1 - 0.14 12.4 11.4 0.81 9.9 5.8 2.4 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Connexin PF00029.19 CDI74013.1 - 0.18 11.6 18.9 0.33 10.7 12.5 2.1 2 0 0 2 2 2 0 Connexin DUF2052 PF09747.9 CDI74013.1 - 0.21 11.7 19.4 0.2 11.8 11.9 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) CPSF100_C PF13299.6 CDI74013.1 - 0.25 11.5 17.5 0.39 10.9 11.4 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4050 PF13259.6 CDI74013.1 - 0.3 11.4 16.2 2.5 8.4 9.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) DUF4834 PF16118.5 CDI74013.1 - 0.31 12.0 28.3 1.8 9.6 1.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF1764 PF08576.10 CDI74013.1 - 0.31 12.0 18.4 2.4 9.1 12.2 2.4 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) DUF572 PF04502.13 CDI74013.1 - 0.35 10.5 16.0 1.9 8.0 10.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) Thg1C PF14413.6 CDI74013.1 - 0.42 10.8 13.6 4 7.6 8.4 2.5 2 0 0 2 2 2 0 Thg1 C terminal domain MAS20 PF02064.15 CDI74013.1 - 0.53 10.4 25.0 0.95 9.6 2.2 2.6 2 0 0 2 2 2 0 MAS20 protein import receptor PH_4 PF15404.6 CDI74013.1 - 0.6 9.9 11.1 1.5 8.6 4.7 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain MecA PF05389.12 CDI74013.1 - 0.6 9.7 16.9 3.3 7.3 0.4 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF4471 PF14740.6 CDI74013.1 - 0.61 9.3 11.6 0.85 8.8 7.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) Isy1 PF06246.12 CDI74013.1 - 0.62 9.6 20.3 1.1 8.8 12.4 2.1 2 0 0 2 2 2 0 Isy1-like splicing family RNA_pol_Rpc4 PF05132.14 CDI74013.1 - 0.7 10.3 14.9 1.2 9.5 10.2 2.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 Adaptin_binding PF10199.9 CDI74013.1 - 0.9 10.2 17.2 1.8 9.2 10.2 2.3 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 MDM10 PF12519.8 CDI74013.1 - 0.97 8.2 14.4 0.81 8.5 9.9 2.1 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 Tim54 PF11711.8 CDI74013.1 - 1.7 7.4 19.4 5 5.8 15.5 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Cellulose_synt PF03552.14 CDI74013.1 - 1.9 6.9 5.3 0.55 8.7 1.8 1.6 2 0 0 2 2 2 0 Cellulose synthase FYDLN_acid PF09538.10 CDI74013.1 - 2.2 9.0 14.6 1.4 9.6 7.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) TCP PF03634.13 CDI74013.1 - 2.3 8.8 26.1 0.67 10.5 2.8 2.3 2 0 0 2 2 2 0 TCP family transcription factor Presenilin PF01080.17 CDI74013.1 - 2.3 6.9 26.1 1.5 7.5 16.7 2.2 2 0 0 2 2 2 0 Presenilin NPR3 PF03666.13 CDI74013.1 - 2.6 6.7 19.2 1.6 7.5 11.7 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Band_3_cyto PF07565.13 CDI74013.1 - 2.9 7.6 20.1 9.2 6.0 13.6 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain CDC45 PF02724.14 CDI74013.1 - 3.4 5.8 15.9 1.2 7.3 11.2 1.9 2 0 0 2 2 2 0 CDC45-like protein Apc15p PF05841.11 CDI74013.1 - 3.5 8.4 28.5 0.046 14.5 11.8 2.8 4 0 0 4 4 2 0 Apc15p protein DUF3408 PF11888.8 CDI74013.1 - 3.5 7.7 23.0 2.9 8.0 15.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) BRF1 PF07741.13 CDI74013.1 - 3.6 8.0 17.9 5.7 7.3 10.5 2.5 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Spt20 PF12090.8 CDI74013.1 - 4.2 6.9 63.9 0.58 9.7 12.0 2.3 2 0 0 2 2 2 0 Spt20 family Mgr1 PF08602.10 CDI74013.1 - 4.3 6.1 6.8 4.7 5.9 1.0 2.2 2 0 0 2 2 2 0 Mgr1-like, i-AAA protease complex subunit DUF719 PF05334.13 CDI74013.1 - 4.4 7.5 21.3 5.2 7.2 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF719) PPL5 PF18168.1 CDI74013.1 - 4.9 6.3 17.8 8.5 5.6 0.9 2.2 2 0 0 2 2 2 0 Prim-pol family 5 Rrn6 PF10214.9 CDI74013.1 - 5.4 5.4 28.7 1.6 7.2 14.4 2.3 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor CNDH2_C PF16858.5 CDI74013.1 - 5.4 6.8 23.6 8.9 6.1 0.4 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Peptidase_S64 PF08192.11 CDI74013.1 - 5.8 5.3 18.6 0.85 8.0 8.0 2.1 2 0 0 2 2 2 0 Peptidase family S64 Afi1 PF07792.12 CDI74013.1 - 6 7.4 21.2 4.6 7.7 14.3 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Baculo_PP31 PF05311.11 CDI74013.1 - 6.8 6.1 18.6 3 7.2 10.9 2.2 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) RR_TM4-6 PF06459.12 CDI74013.1 - 7.9 6.2 24.4 6.5 6.5 17.9 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF2126 PF09899.9 CDI74013.1 - 8.4 4.3 14.7 2.3 6.2 8.0 2.0 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) FAM91_C PF14648.6 CDI74013.1 - 9 5.0 11.6 3.1 6.5 6.3 2.1 2 0 0 2 2 2 0 FAM91 C-terminus UPF0560 PF10577.9 CDI74013.1 - 9.3 4.6 34.0 3.6 6.0 19.8 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 Membralin PF09746.9 CDI74013.1 - 9.3 5.2 12.6 3.8 6.5 7.4 2.0 2 0 0 2 2 2 0 Tumour-associated protein DUF966 PF06136.13 CDI74015.1 - 0.016 15.0 22.8 0.022 14.5 22.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) VIR_N PF15912.5 CDI74015.1 - 0.03 13.9 13.5 0.044 13.4 13.5 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Plant_all_beta PF10532.9 CDI74015.1 - 0.046 14.0 0.3 0.046 14.0 0.3 2.4 1 1 1 2 2 2 0 Plant specific N-all beta domain PAT1 PF09770.9 CDI74015.1 - 2.8 6.1 48.2 3.7 5.7 48.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4551 PF15087.6 CDI74015.1 - 6.2 5.5 24.7 9.4 4.9 24.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Hamartin PF04388.12 CDI74015.1 - 7.3 5.1 29.6 8.9 4.8 29.6 1.1 1 0 0 1 1 1 0 Hamartin protein CDK5_activator PF03261.15 CDI74015.1 - 8.7 5.8 23.0 10 5.6 23.0 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Sin_N PF04801.13 CDI74015.1 - 9.8 5.3 42.9 19 4.3 42.9 1.4 1 0 0 1 1 1 0 Sin-like protein conserved region cNMP_binding PF00027.29 CDI74016.1 - 1.8e-07 31.2 0.1 2.9e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain RAP1 PF07218.11 CDI74016.1 - 0.0017 16.7 19.5 0.0021 16.4 19.5 1.2 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) Caldesmon PF02029.15 CDI74016.1 - 0.034 12.9 41.3 0.042 12.6 41.3 1.1 1 0 0 1 1 1 0 Caldesmon SOBP PF15279.6 CDI74016.1 - 0.048 14.3 43.7 0.071 13.7 43.7 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein CDC27 PF09507.10 CDI74016.1 - 0.42 9.9 43.3 0.62 9.4 43.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Utp14 PF04615.13 CDI74016.1 - 0.53 8.8 43.8 0.57 8.7 43.8 1.1 1 0 0 1 1 1 0 Utp14 protein DUF966 PF06136.13 CDI74016.1 - 0.64 9.7 42.7 0.82 9.3 42.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) CAC1F_C PF16885.5 CDI74016.1 - 1.1 8.9 32.3 1.5 8.4 32.3 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term BAF1_ABF1 PF04684.13 CDI74016.1 - 1.1 8.2 38.6 1.6 7.7 38.6 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Virul_fac_BrkB PF03631.15 CDI74016.1 - 4.4 6.8 13.2 0.014 15.0 3.9 1.5 1 1 1 2 2 2 0 Virulence factor BrkB DUF3523 PF12037.8 CDI74016.1 - 4.5 6.6 50.0 0.48 9.7 43.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3523) Asp-B-Hydro_N PF05279.11 CDI74016.1 - 5.3 7.0 23.7 6.3 6.8 23.7 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4551 PF15087.6 CDI74016.1 - 7.8 5.2 37.2 9.6 4.9 37.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SOG2 PF10428.9 CDI74016.1 - 8.3 5.5 50.1 9.9 5.2 50.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein RskA PF10099.9 CDI74017.1 - 9.8e-05 22.7 2.2 9.8e-05 22.7 2.2 10.3 2 2 2 5 5 5 2 Anti-sigma-K factor rskA Exonuc_VII_L PF02601.15 CDI74017.1 - 0.00085 19.0 22.9 0.00085 19.0 22.9 6.0 3 2 2 5 5 5 1 Exonuclease VII, large subunit Spt20 PF12090.8 CDI74017.1 - 0.0065 16.1 22.1 0.0065 16.1 22.1 12.0 4 2 4 8 8 8 1 Spt20 family PPP4R2 PF09184.11 CDI74018.1 - 7.8 6.0 27.9 13 5.3 27.9 1.3 1 0 0 1 1 1 0 PPP4R2 SAPS PF04499.15 CDI74018.1 - 8 5.1 42.5 21 3.8 42.5 1.6 1 1 0 1 1 1 0 SIT4 phosphatase-associated protein Androgen_recep PF02166.16 CDI74019.1 - 0.0026 16.7 14.6 0.0026 16.7 14.6 4.8 2 1 2 4 4 4 1 Androgen receptor RskA PF10099.9 CDI74019.1 - 7 6.9 32.3 13 6.0 16.0 3.3 1 1 1 2 2 2 0 Anti-sigma-K factor rskA tRNA-synt_1 PF00133.22 CDI74020.1 - 2.1e-08 32.9 24.1 9.6e-07 27.4 8.3 10.3 7 3 4 11 11 11 5 tRNA synthetases class I (I, L, M and V) CNDH2_C PF16858.5 CDI74020.1 - 0.00051 20.0 16.4 0.00051 20.0 16.4 12.0 6 3 5 11 11 11 3 Condensin II complex subunit CAP-H2 or CNDH2, C-term RskA PF10099.9 CDI74020.1 - 0.0087 16.4 15.4 0.0087 16.4 15.4 17.8 2 2 8 12 12 12 3 Anti-sigma-K factor rskA RskA PF10099.9 CDI74021.1 - 0.0002 21.7 2.4 0.0002 21.7 2.4 8.1 2 2 2 4 4 4 1 Anti-sigma-K factor rskA Ribosomal_60s PF00428.19 CDI74021.1 - 0.0065 17.0 4.0 0.0065 17.0 4.0 10.0 4 2 4 8 8 8 1 60s Acidic ribosomal protein Caldesmon PF02029.15 CDI74021.1 - 2.7 6.7 88.1 0.41 9.4 8.5 2.5 2 1 0 2 2 2 0 Caldesmon CDC27 PF09507.10 CDI74022.1 - 0.028 13.8 34.4 0.035 13.5 34.4 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CDK5_activator PF03261.15 CDI74022.1 - 0.52 9.8 37.2 0.68 9.4 37.2 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF4131 PF13567.6 CDI74022.1 - 0.7 9.5 20.5 2.2 7.9 20.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) DUF4045 PF13254.6 CDI74022.1 - 0.73 9.4 36.5 0.85 9.2 36.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PA26 PF04636.13 CDI74022.1 - 0.93 8.3 30.4 1.4 7.8 30.4 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Dapper PF15268.6 CDI74022.1 - 1.5 7.5 50.3 1.7 7.4 50.3 1.1 1 0 0 1 1 1 0 Dapper Nha1_C PF08619.10 CDI74022.1 - 8.8 5.4 42.4 11 5.1 42.4 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Sec23_trunk PF04811.15 CDI74023.1 - 6.8e-21 74.9 0.0 6.8e-21 74.9 0.0 2.7 4 0 0 4 4 4 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 CDI74023.1 - 3.9e-16 58.7 0.5 3.9e-16 58.7 0.5 2.8 3 1 0 3 3 3 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CDI74023.1 - 7.2e-09 35.5 6.0 1.5e-08 34.6 6.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 CDI74023.1 - 1.5e-08 35.3 0.0 2.2e-07 31.5 0.0 2.9 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Peptidase_M18 PF02127.15 CDI74024.1 - 4.6e-133 444.2 0.0 6.7e-98 328.3 0.0 2.0 2 0 0 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 CDI74024.1 - 2.3e-06 26.9 0.0 4.3e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase Actin PF00022.19 CDI74026.1 - 1.7e-24 86.2 0.0 1.9e-21 76.1 0.0 2.8 2 1 0 2 2 2 2 Actin PPR_2 PF13041.6 CDI74027.1 - 8.4e-49 163.6 3.7 3.3e-15 56.0 0.0 6.3 2 1 4 6 6 6 6 PPR repeat family PPR_3 PF13812.6 CDI74027.1 - 2.8e-34 117.0 0.3 6.5e-14 51.8 0.0 4.4 4 0 0 4 4 4 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 CDI74027.1 - 4.3e-30 103.1 6.6 2e-08 33.8 0.0 7.2 7 0 0 7 7 7 6 PPR repeat PPR PF01535.20 CDI74027.1 - 1.2e-27 94.1 12.3 5.6e-06 26.3 0.0 9.1 8 2 0 8 8 8 4 PPR repeat PPR_long PF17177.4 CDI74027.1 - 3.3e-19 69.1 0.2 4.5e-11 42.5 0.0 2.9 1 1 2 3 3 3 2 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 CDI74027.1 - 0.005 16.7 0.0 6.5 6.6 0.0 3.1 2 1 1 3 3 3 2 Mitochondrial ATPase expression ATG16 PF08614.11 CDI74028.1 - 0.0013 19.0 10.3 0.0013 19.0 10.3 9.7 4 3 2 7 7 7 2 Autophagy protein 16 (ATG16) Cluap1 PF10234.9 CDI74028.1 - 0.004 16.6 10.1 0.004 16.6 10.1 6.2 6 2 0 6 6 6 1 Clusterin-associated protein-1 HALZ PF02183.18 CDI74028.1 - 0.0041 17.3 96.6 0.035 14.3 1.5 13.4 10 4 1 11 11 11 4 Homeobox associated leucine zipper KASH_CCD PF14662.6 CDI74028.1 - 1.4 8.7 114.5 0.21 11.4 12.4 7.1 6 1 0 6 6 6 0 Coiled-coil region of CCDC155 or KASH PK PF00224.21 CDI74029.1 - 1e-50 172.6 0.1 2.4e-32 112.2 0.1 3.2 3 0 0 3 3 3 3 Pyruvate kinase, barrel domain Gly-zipper_YMGG PF13441.6 CDI74029.1 - 1.1e-05 25.0 0.1 1.1e-05 25.0 0.1 2.6 2 0 0 2 2 1 1 YMGG-like Gly-zipper Gly-zipper_OmpA PF13436.6 CDI74029.1 - 0.00091 19.0 4.8 0.00091 19.0 4.8 2.7 2 0 0 2 2 1 1 Glycine-zipper domain PK_C PF02887.16 CDI74029.1 - 0.0028 17.9 0.1 0.13 12.5 0.2 2.7 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain N-SET PF11764.8 CDI74029.1 - 0.0058 16.8 0.3 0.0058 16.8 0.3 3.5 3 1 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component N HpcH_HpaI PF03328.14 CDI74029.1 - 0.01 15.0 3.4 1.1 8.3 0.1 2.6 2 1 0 2 2 2 0 HpcH/HpaI aldolase/citrate lyase family ESM4 PF15952.5 CDI74029.1 - 0.03 14.8 39.4 0.094 13.1 19.2 3.2 3 0 0 3 3 3 0 Enhancer of split M4 family Spt20 PF12090.8 CDI74029.1 - 0.034 13.8 69.6 0.37 10.4 32.6 3.3 3 0 0 3 3 3 0 Spt20 family PPP4R2 PF09184.11 CDI74029.1 - 0.052 13.1 19.0 0.2 11.2 15.7 2.4 2 0 0 2 2 2 0 PPP4R2 AAA_23 PF13476.6 CDI74029.1 - 0.34 11.4 21.9 3 8.3 0.5 3.3 3 0 0 3 3 3 0 AAA domain DUF3740 PF12548.8 CDI74029.1 - 0.35 11.3 0.1 0.35 11.3 0.1 3.7 3 1 0 3 3 3 0 Sulfatase protein DUF1645 PF07816.11 CDI74029.1 - 0.42 11.2 37.6 0.29 11.7 25.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1645) Spore_YhcN_YlaJ PF09580.10 CDI74029.1 - 0.55 10.3 0.0 0.55 10.3 0.0 3.1 3 0 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Presenilin PF01080.17 CDI74029.1 - 0.66 8.7 34.0 0.77 8.5 19.9 3.0 3 0 0 3 3 3 0 Presenilin FAM176 PF14851.6 CDI74029.1 - 1.2 8.8 24.3 0.17 11.5 0.2 3.6 3 0 0 3 3 3 0 FAM176 family Usp PF00582.26 CDI74029.1 - 2.1 8.9 8.9 11 6.5 0.3 3.2 3 0 0 3 3 3 0 Universal stress protein family CPSF100_C PF13299.6 CDI74029.1 - 3.4 7.8 26.2 0.15 12.3 0.7 3.3 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Pinin_SDK_memA PF04696.13 CDI74029.1 - 3.5 7.7 40.0 0.51 10.4 6.3 3.2 3 0 0 3 3 3 0 pinin/SDK/memA/ protein conserved region MMR1 PF08505.10 CDI74029.1 - 5.7 7.2 46.4 6.2 7.0 1.5 3.1 3 0 0 3 3 3 0 Mitochondrial Myo2 receptor-related protein Nha1_C PF08619.10 CDI74029.1 - 6.2 5.9 34.1 4.2 6.5 0.5 3.2 3 0 0 3 3 3 0 Alkali metal cation/H+ antiporter Nha1 C terminus DUF2052 PF09747.9 CDI74029.1 - 6.2 6.9 31.6 0.91 9.6 1.2 3.2 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Neur_chan_memb PF02932.16 CDI74029.1 - 7.5 6.5 26.1 3.9 7.4 0.6 3.1 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region DnaJ-X PF14308.6 CDI74029.1 - 9.2 5.6 18.2 0.5 9.8 0.5 3.2 3 0 0 3 3 3 0 X-domain of DnaJ-containing SR-25 PF10500.9 CDI74030.1 - 8.3e-06 25.6 20.6 8.3e-06 25.6 20.6 3.9 4 0 0 4 4 4 2 Nuclear RNA-splicing-associated protein Pex14_N PF04695.13 CDI74030.1 - 0.00015 22.5 69.7 0.039 14.6 4.9 4.2 4 0 0 4 4 4 2 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2722 PF10846.8 CDI74030.1 - 0.0046 16.0 8.4 0.0046 16.0 8.4 5.1 4 1 1 5 5 3 1 Protein of unknown function (DUF2722) SelP_N PF04592.14 CDI74030.1 - 0.0052 16.2 8.7 0.0052 16.2 8.7 3.7 4 0 0 4 4 4 1 Selenoprotein P, N terminal region Spt20 PF12090.8 CDI74030.1 - 0.006 16.2 13.7 0.006 16.2 13.7 4.7 4 1 0 4 4 3 2 Spt20 family SOBP PF15279.6 CDI74030.1 - 0.011 16.4 40.3 0.068 13.8 21.1 2.2 2 0 0 2 2 2 0 Sine oculis-binding protein RskA PF10099.9 CDI74030.1 - 0.17 12.2 86.6 0.042 14.1 15.9 4.6 2 2 1 4 4 4 0 Anti-sigma-K factor rskA RPA43_OB PF17875.1 CDI74030.1 - 1.4 9.6 28.0 1.5 9.5 1.0 4.1 4 0 0 4 4 4 0 RPA43 OB domain in RNA Pol I FAM76 PF16046.5 CDI74030.1 - 3.4 6.9 34.0 0.54 9.6 13.2 4.0 4 0 0 4 4 4 0 FAM76 protein EPL1 PF10513.9 CDI74030.1 - 3.8 7.9 43.5 0.99 9.8 16.5 4.2 4 0 0 4 4 4 0 Enhancer of polycomb-like DUF4746 PF15928.5 CDI74030.1 - 6.8 6.0 24.1 0.063 12.7 8.7 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4746) DUF4179 PF13786.6 CDI74030.1 - 8.6 6.9 13.2 6.9 7.2 4.1 3.5 4 1 0 4 4 3 0 Domain of unknown function (DUF4179) Eapp_C PF10238.9 CDI74030.1 - 8.8 6.4 40.1 0.84 9.7 13.8 4.2 4 0 0 4 4 4 0 E2F-associated phosphoprotein TFIIF_alpha PF05793.12 CDI74033.1 - 0.0039 15.8 19.7 0.0042 15.7 19.7 1.0 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Apt1 PF10351.9 CDI74033.1 - 0.027 13.3 26.1 0.029 13.3 26.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain PI3K_1B_p101 PF10486.9 CDI74033.1 - 0.11 10.2 19.9 0.13 10.1 19.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit GREB1 PF15782.5 CDI74033.1 - 0.13 9.3 25.6 0.17 9.0 25.6 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AF-4 PF05110.13 CDI74033.1 - 0.15 10.1 33.7 0.19 9.7 33.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein BSP_II PF05432.11 CDI74033.1 - 0.26 10.9 19.0 0.3 10.7 19.0 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Lin-8 PF03353.15 CDI74033.1 - 0.27 10.7 26.8 0.33 10.5 26.8 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist ALMT PF11744.8 CDI74033.1 - 0.35 9.6 20.4 0.44 9.3 20.4 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter MPM1 PF17234.2 CDI74033.1 - 0.47 10.7 23.7 0.73 10.1 23.7 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 DUF908 PF06012.12 CDI74033.1 - 0.69 9.3 23.6 0.92 8.9 23.6 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SPX PF03105.19 CDI74033.1 - 0.75 9.6 29.6 0.93 9.3 29.6 1.2 1 0 0 1 1 1 0 SPX domain DUF1387 PF07139.11 CDI74033.1 - 0.78 9.4 26.7 1.1 8.9 26.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Mem_trans PF03547.18 CDI74033.1 - 0.81 8.0 10.3 0.86 7.9 10.3 1.2 1 0 0 1 1 1 0 Membrane transport protein Miga PF10265.9 CDI74033.1 - 1.2 8.0 24.6 1.5 7.8 24.6 1.1 1 0 0 1 1 1 0 Mitoguardin Draxin PF15550.6 CDI74033.1 - 1.3 8.8 21.3 1.7 8.4 21.3 1.3 1 0 0 1 1 1 0 Draxin CDC45 PF02724.14 CDI74033.1 - 1.5 7.1 22.4 1.8 6.7 22.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Spt20 PF12090.8 CDI74033.1 - 1.5 8.4 57.7 3.1 7.4 57.6 1.7 1 1 0 1 1 1 0 Spt20 family UPF0524 PF15823.5 CDI74033.1 - 1.7 8.0 12.3 2.8 7.3 12.3 1.5 1 0 0 1 1 1 0 UPF0524 of C3orf70 DUF4647 PF15504.6 CDI74033.1 - 2.2 7.3 26.0 2.7 7.0 26.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DUF4813 PF16072.5 CDI74033.1 - 2.6 7.6 27.1 3.4 7.3 27.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Plasmodium_Vir PF05795.11 CDI74033.1 - 2.9 7.2 19.6 3.5 6.9 19.6 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SLC12 PF03522.15 CDI74033.1 - 4.2 6.3 28.3 5 6.0 28.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Membralin PF09746.9 CDI74033.1 - 5.2 6.0 15.7 5.7 5.9 15.7 1.2 1 0 0 1 1 1 0 Tumour-associated protein Ndc1_Nup PF09531.10 CDI74033.1 - 5.4 5.6 29.1 6.1 5.4 29.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Peptidase_S64 PF08192.11 CDI74033.1 - 6.2 5.2 33.7 7.2 5.0 33.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 Mcm10 PF09332.11 CDI74033.1 - 7.2 5.9 33.2 8.8 5.6 33.2 1.1 1 0 0 1 1 1 0 Mcm10 replication factor Nop53 PF07767.11 CDI74033.1 - 7.6 5.8 34.4 9.5 5.5 34.4 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF966 PF06136.13 CDI74033.1 - 8 6.1 32.0 12 5.5 32.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) CAML PF14963.6 CDI74033.1 - 9 6.3 17.7 11 6.1 17.7 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Sin_N PF04801.13 CDI74035.1 - 0.0011 18.3 7.3 0.0011 18.3 7.3 4.3 2 1 2 4 4 4 1 Sin-like protein conserved region DUF2722 PF10846.8 CDI74036.1 - 0.0016 17.5 4.9 0.0016 17.5 4.9 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF2722) eIF3_subunit PF08597.10 CDI74037.1 - 0.0012 18.8 14.5 0.0012 18.8 14.5 1.7 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit PAT1 PF09770.9 CDI74037.1 - 0.0019 16.6 40.3 0.0019 16.6 40.3 1.4 2 0 0 2 2 2 1 Topoisomerase II-associated protein PAT1 Lactamase_B_6 PF16661.5 CDI74037.1 - 0.017 14.5 0.0 0.017 14.5 0.0 2.3 3 1 1 4 4 4 0 Metallo-beta-lactamase superfamily domain Utp14 PF04615.13 CDI74037.1 - 1.2 7.6 36.8 0.0049 15.5 26.2 2.1 2 0 0 2 2 2 0 Utp14 protein CNDH2_C PF16858.5 CDI74037.1 - 4.6 7.0 34.0 8.2 6.2 34.0 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term NUC PF18510.1 CDI74037.1 - 8.6 6.8 14.7 17 5.8 14.7 1.5 1 0 0 1 1 1 0 Nuclease domain DUF2722 PF10846.8 CDI74039.1 - 7.8e-06 25.1 6.4 7.8e-06 25.1 6.4 3.5 3 1 0 3 3 3 1 Protein of unknown function (DUF2722) Glt_symporter PF03616.14 CDI74039.1 - 0.017 13.8 0.5 0.017 13.8 0.5 2.7 2 0 0 2 2 2 0 Sodium/glutamate symporter MPM1 PF17234.2 CDI74039.1 - 0.03 14.6 1.0 0.03 14.6 1.0 3.1 3 0 0 3 3 3 0 Mitochondrial peculiar membrane protein 1 SID-1_RNA_chan PF13965.6 CDI74039.1 - 0.36 9.2 3.6 2.5 6.4 1.1 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 MecA PF05389.12 CDI74039.1 - 0.81 9.3 18.5 0.14 11.7 0.4 2.7 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) AAR2 PF05282.11 CDI74039.1 - 0.84 9.0 9.2 9.6 5.5 5.0 2.4 2 0 0 2 2 2 0 AAR2 protein EOS1 PF12326.8 CDI74039.1 - 2.5 8.0 14.8 1.6 8.6 0.3 2.8 3 0 0 3 3 3 0 N-glycosylation protein Mlh1_C PF16413.5 CDI74039.1 - 3.6 6.9 16.3 0.52 9.6 0.8 2.6 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus RNase_H2_suC PF08615.11 CDI74039.1 - 5.3 7.2 12.1 2.2 8.4 0.0 2.7 3 0 0 3 3 3 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) PH_12 PF16457.5 CDI74040.1 - 0.15 12.6 2.4 0.49 10.9 2.4 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain SUIM_assoc PF16619.5 CDI74040.1 - 0.65 10.1 29.6 0.88 9.7 11.3 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Rota_VP2 PF05087.12 CDI74041.1 - 0.039 12.1 2.2 0.051 11.7 2.2 1.0 1 0 0 1 1 1 0 Rotavirus VP2 protein DUF755 PF05501.11 CDI74043.1 - 0.0014 18.8 27.8 0.0014 18.8 27.8 5.2 4 1 1 5 5 5 1 Domain of unknown function (DUF755) UPF0139 PF03669.13 CDI74044.1 - 2e-06 27.5 0.0 2.4e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) Mito_carr PF00153.27 CDI74045.1 - 4.1e-36 122.8 11.6 8.8e-14 51.2 1.2 5.4 4 2 0 4 4 4 4 Mitochondrial carrier protein RskA PF10099.9 CDI74045.1 - 0.072 13.4 14.9 1.2 9.4 10.4 2.6 2 0 0 2 2 2 0 Anti-sigma-K factor rskA V_ATPase_I PF01496.19 CDI74045.1 - 0.29 9.0 7.7 0.47 8.3 7.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FHIPEP PF00771.20 CDI74045.1 - 0.74 8.2 6.1 1.1 7.7 6.1 1.2 1 0 0 1 1 1 0 FHIPEP family DUF4407 PF14362.6 CDI74045.1 - 0.78 9.0 13.5 1.5 8.1 13.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DNApol_Exo PF18136.1 CDI74045.1 - 1.6 7.8 6.9 0.14 11.3 1.6 2.0 2 0 0 2 2 2 0 DNA mitochondrial polymerase exonuclease domain RED_N PF07808.13 CDI74045.1 - 1.8 8.1 16.4 0.82 9.2 9.5 2.5 2 0 0 2 2 2 0 RED-like protein N-terminal region Med15 PF09606.10 CDI74045.1 - 2 7.0 37.9 3 6.4 37.9 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal BRF1 PF07741.13 CDI74045.1 - 4.4 7.7 10.4 6.7 7.1 6.2 2.7 3 0 0 3 3 3 0 Brf1-like TBP-binding domain zf-CCCH PF00642.24 CDI74048.1 - 3.4e-08 33.2 18.7 8e-05 22.5 0.8 3.5 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 CDI74048.1 - 4.3e-06 26.9 8.5 0.0029 17.8 2.7 2.3 1 1 1 2 2 2 2 Zinc-finger containing family Torus PF16131.5 CDI74048.1 - 0.0011 19.7 16.1 0.52 11.0 4.3 3.4 1 1 2 3 3 3 3 Torus domain zf-C3H1 PF10650.9 CDI74048.1 - 0.0015 18.2 2.8 0.088 12.5 1.7 2.8 2 0 0 2 2 2 1 Putative zinc-finger domain RskA PF10099.9 CDI74048.1 - 0.0018 18.6 14.3 0.1 12.9 2.5 2.2 2 0 0 2 2 2 2 Anti-sigma-K factor rskA zf-CCCH_4 PF18044.1 CDI74048.1 - 0.0048 16.7 23.6 0.034 14.0 5.7 4.0 3 1 0 3 3 3 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 CDI74048.1 - 0.016 15.6 0.9 0.016 15.6 0.9 3.6 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 CDI74048.1 - 0.15 12.1 27.0 0.52 10.4 3.8 4.1 3 1 0 3 3 3 0 Zinc finger domain PsbQ PF05757.11 CDI74049.1 - 0.014 15.2 4.6 0.019 14.7 4.6 1.1 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) TFIIA PF03153.13 CDI74049.1 - 0.063 13.3 9.0 0.075 13.0 9.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI74049.1 - 1.9 8.7 23.9 1.6e+02 2.5 23.9 2.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA YebO PF13974.6 CDI74049.1 - 2.1 8.5 7.9 4.7 7.4 7.9 1.5 1 0 0 1 1 1 0 YebO-like protein DUF588 PF04535.12 CDI74049.1 - 4.8 7.0 11.0 7.3 6.4 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF588) Jnk-SapK_ap_N PF09744.9 CDI74050.1 - 0.003 17.8 6.7 0.003 17.8 6.7 10.3 2 2 9 12 12 12 4 JNK_SAPK-associated protein-1 RskA PF10099.9 CDI74052.1 - 0.0018 18.6 3.7 0.0018 18.6 3.7 5.1 2 2 2 4 4 4 2 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI74053.1 - 0.67 9.5 34.0 0.74 9.4 34.0 1.1 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI74053.1 - 4.8 7.1 25.1 4.8 7.1 25.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Androgen_recep PF02166.16 CDI74053.1 - 8.2 5.1 16.4 7.3 5.3 16.4 1.1 1 0 0 1 1 1 0 Androgen receptor DUF1168 PF06658.12 CDI74053.1 - 9.4 6.1 30.9 11 5.9 30.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Caldesmon PF02029.15 CDI74055.1 - 9.9e-06 24.6 1.6 9.9e-06 24.6 1.6 3.2 2 1 0 2 2 1 1 Caldesmon Tetraspanin PF00335.20 CDI74055.1 - 1.9e-05 24.5 1.8 0.071 12.8 0.0 3.1 2 1 1 3 3 2 1 Tetraspanin family Spt20 PF12090.8 CDI74055.1 - 0.00039 20.1 34.4 0.0009 18.9 10.6 6.8 5 2 1 7 7 4 2 Spt20 family RskA PF10099.9 CDI74055.1 - 0.00039 20.8 5.4 0.00039 20.8 5.4 9.4 3 1 2 5 5 4 1 Anti-sigma-K factor rskA Nha1_C PF08619.10 CDI74055.1 - 0.00056 19.3 3.3 0.00056 19.3 3.3 5.2 4 1 1 5 5 4 2 Alkali metal cation/H+ antiporter Nha1 C terminus YfhO PF09586.10 CDI74055.1 - 0.00082 17.7 4.2 0.00082 17.7 4.2 3.9 2 1 1 3 3 1 1 Bacterial membrane protein YfhO DUF4834 PF16118.5 CDI74055.1 - 0.0019 19.1 0.2 0.0019 19.1 0.2 7.4 6 2 1 7 7 6 1 Domain of unknown function (DUF4834) DUF1980 PF09323.10 CDI74055.1 - 0.0027 17.6 2.3 0.0027 17.6 2.3 6.1 4 2 0 4 4 2 2 Domain of unknown function (DUF1980) Mem_trans PF03547.18 CDI74055.1 - 0.0037 15.7 0.4 0.0037 15.7 0.4 5.1 4 1 0 5 5 4 1 Membrane transport protein SR-25 PF10500.9 CDI74055.1 - 0.0095 15.6 13.3 0.0095 15.6 13.3 7.1 5 3 3 8 8 5 2 Nuclear RNA-splicing-associated protein NEMP PF10225.9 CDI74055.1 - 0.012 15.3 0.8 0.012 15.3 0.8 5.0 5 1 1 6 6 5 0 NEMP family FA_desaturase PF00487.24 CDI74055.1 - 0.085 12.7 0.0 0.33 10.8 0.0 2.0 1 0 0 1 1 1 0 Fatty acid desaturase DUF3801 PF12687.7 CDI74055.1 - 0.11 12.5 0.0 0.11 12.5 0.0 5.9 2 2 1 3 3 1 0 Protein of unknown function (DUF3801) RCR PF12273.8 CDI74055.1 - 0.26 12.0 0.0 0.26 12.0 0.0 6.3 3 2 1 4 4 1 0 Chitin synthesis regulation, resistance to Congo red V_ATPase_I PF01496.19 CDI74055.1 - 2.2 6.1 65.6 0.059 11.3 9.4 4.2 4 0 0 4 4 4 0 V-type ATPase 116kDa subunit family SID-1_RNA_chan PF13965.6 CDI74055.1 - 8 4.7 34.6 0.16 10.4 3.8 4.2 3 1 1 4 4 4 0 dsRNA-gated channel SID-1 TFIIA PF03153.13 CDI74056.1 - 0.0023 18.0 19.7 0.0023 18.0 19.7 3.8 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit CCSAP PF15748.5 CDI74058.1 - 2.8e-05 24.4 22.5 2.8e-05 24.4 22.5 2.0 2 0 0 2 2 2 1 Centriole, cilia and spindle-associated DUF572 PF04502.13 CDI74058.1 - 0.00015 21.5 9.8 0.00015 21.5 9.8 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF572) NPR3 PF03666.13 CDI74058.1 - 0.00018 20.4 12.3 0.00035 19.5 12.3 1.5 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.12 CDI74058.1 - 0.00054 19.9 18.2 0.00054 19.9 18.2 1.8 2 0 0 2 2 2 1 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 CDI74058.1 - 0.00058 18.9 7.1 0.00058 18.9 7.1 1.8 2 0 0 2 2 2 1 Domain of Unknown Function (DUF913) STAC2_u1 PF16664.5 CDI74058.1 - 0.00087 19.8 15.3 0.0013 19.2 13.1 2.4 2 0 0 2 2 2 1 Unstructured on SH3 and cysteine-rich domain-containing protein 2 LMBR1 PF04791.16 CDI74058.1 - 0.0011 17.9 9.9 0.0017 17.3 9.9 1.3 1 0 0 1 1 1 1 LMBR1-like membrane protein RtcB PF01139.17 CDI74058.1 - 0.0011 18.2 1.4 0.0013 18.1 1.4 1.2 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Connexin PF00029.19 CDI74058.1 - 0.0015 18.4 13.1 0.0015 18.4 13.1 1.9 3 0 0 3 3 1 1 Connexin Presenilin PF01080.17 CDI74058.1 - 0.0016 17.3 22.3 0.0016 17.3 22.3 1.9 2 0 0 2 2 2 1 Presenilin Hid1 PF12722.7 CDI74058.1 - 0.0016 16.7 16.5 0.0025 16.0 16.5 1.4 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein DDHD PF02862.17 CDI74058.1 - 0.0022 18.2 14.8 0.0022 18.2 14.8 2.3 2 1 0 2 2 2 1 DDHD domain SID-1_RNA_chan PF13965.6 CDI74058.1 - 0.0024 16.4 3.3 0.0024 16.4 3.3 1.6 2 0 0 2 2 2 1 dsRNA-gated channel SID-1 CSG2 PF16965.5 CDI74058.1 - 0.0027 16.7 7.6 0.0052 15.8 7.6 1.5 1 0 0 1 1 1 1 Ceramide synthase regulator SpoIIP PF07454.11 CDI74058.1 - 0.003 17.1 17.0 0.003 17.1 17.0 1.7 2 0 0 2 2 2 1 Stage II sporulation protein P (SpoIIP) AAA_11 PF13086.6 CDI74058.1 - 0.0031 17.3 16.7 0.0031 17.3 16.7 1.7 2 0 0 2 2 1 1 AAA domain DUF4045 PF13254.6 CDI74058.1 - 0.0036 17.0 13.9 0.0036 17.0 13.9 1.5 2 0 0 2 2 1 1 Domain of unknown function (DUF4045) PBP1_TM PF14812.6 CDI74058.1 - 0.0091 16.3 7.9 0.023 15.0 7.9 1.6 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2370 PF10176.9 CDI74058.1 - 0.019 14.6 8.1 0.044 13.4 8.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Orf78 PF06024.12 CDI74058.1 - 0.023 15.0 6.6 0.023 15.0 6.6 3.7 2 2 1 3 3 2 0 Orf78 (ac78) CDC45 PF02724.14 CDI74058.1 - 0.11 10.8 19.2 0.0061 14.9 14.0 1.5 2 0 0 2 2 2 0 CDC45-like protein Neuregulin PF02158.15 CDI74058.1 - 0.13 11.5 0.1 0.13 11.5 0.1 3.0 2 1 0 2 2 1 0 Neuregulin intracellular region V_ATPase_I PF01496.19 CDI74058.1 - 0.14 10.1 24.1 0.036 12.0 21.1 1.5 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family AF-4 PF05110.13 CDI74058.1 - 0.15 10.2 29.3 0.27 9.3 29.3 1.4 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TRAP_alpha PF03896.16 CDI74058.1 - 0.16 11.1 9.2 0.31 10.2 9.2 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit HCO3_cotransp PF00955.21 CDI74058.1 - 0.18 10.6 11.2 0.36 9.6 11.2 1.4 1 0 0 1 1 1 0 HCO3- transporter family Sin_N PF04801.13 CDI74058.1 - 0.2 10.8 42.2 0.92 8.6 39.2 2.3 2 0 0 2 2 2 0 Sin-like protein conserved region Neur_chan_memb PF02932.16 CDI74058.1 - 0.2 11.7 22.3 0.49 10.4 21.8 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Sec62 PF03839.16 CDI74058.1 - 0.26 10.8 16.7 0.058 12.9 13.2 1.7 2 0 0 2 2 1 0 Translocation protein Sec62 Endostatin PF06482.11 CDI74058.1 - 0.27 10.6 25.3 0.21 11.1 23.3 1.7 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Otopetrin PF03189.13 CDI74058.1 - 0.62 8.8 12.8 0.4 9.4 10.6 1.8 2 0 0 2 2 2 0 Otopetrin DAG_kinase_N PF14513.6 CDI74058.1 - 0.63 10.2 26.4 2 8.6 25.6 2.1 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Peptidase_S64 PF08192.11 CDI74058.1 - 0.64 8.4 18.7 0.14 10.6 15.6 1.5 2 0 0 2 2 1 0 Peptidase family S64 CLN3 PF02487.17 CDI74058.1 - 0.78 8.7 21.5 0.36 9.8 17.4 2.1 2 0 0 2 2 2 0 CLN3 protein Nha1_C PF08619.10 CDI74058.1 - 0.82 8.8 29.4 0.55 9.4 27.1 1.7 2 0 0 2 2 2 0 Alkali metal cation/H+ antiporter Nha1 C terminus LptF_LptG PF03739.14 CDI74058.1 - 1 8.1 7.4 1.8 7.3 7.4 1.4 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG SLC12 PF03522.15 CDI74058.1 - 1.1 8.3 26.9 0.063 12.3 21.9 1.4 2 0 0 2 2 1 0 Solute carrier family 12 Band_3_cyto PF07565.13 CDI74058.1 - 1.2 8.9 24.1 0.21 11.3 19.8 2.0 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Scs3p PF10261.9 CDI74058.1 - 1.2 8.6 10.9 0.37 10.3 7.4 1.9 2 0 0 2 2 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Anoctamin PF04547.12 CDI74058.1 - 1.3 7.8 14.0 0.3 9.9 10.8 1.5 2 0 0 2 2 2 0 Calcium-activated chloride channel Radical_SAM_N PF08497.10 CDI74058.1 - 1.5 8.0 8.7 2.8 7.1 8.7 1.5 1 0 0 1 1 1 0 Radical SAM N-terminal PAT1 PF09770.9 CDI74058.1 - 1.5 7.0 48.8 0.54 8.5 45.1 1.8 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 PPL5 PF18168.1 CDI74058.1 - 1.5 8.0 17.1 3.5 6.8 17.1 1.6 1 0 0 1 1 1 0 Prim-pol family 5 Hamartin PF04388.12 CDI74058.1 - 1.8 7.1 30.0 0.13 10.9 24.7 1.7 2 0 0 2 2 2 0 Hamartin protein Ndc1_Nup PF09531.10 CDI74058.1 - 1.9 7.1 23.1 1 8.0 20.7 1.7 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup DUF2347 PF09804.9 CDI74058.1 - 2 7.9 12.3 3.6 7.1 12.3 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) TCP PF03634.13 CDI74058.1 - 2.2 8.8 33.8 4.4 7.8 30.9 2.5 2 0 0 2 2 2 0 TCP family transcription factor 7tm_1 PF00001.21 CDI74058.1 - 2.5 7.4 0.0 2.5 7.4 0.0 2.9 2 2 0 2 2 1 0 7 transmembrane receptor (rhodopsin family) Caldesmon PF02029.15 CDI74058.1 - 2.7 6.6 28.0 0.2 10.4 22.1 1.8 2 0 0 2 2 2 0 Caldesmon MDM31_MDM32 PF08118.11 CDI74058.1 - 3.2 6.3 16.6 6.9 5.2 16.6 1.5 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Cellulose_synt PF03552.14 CDI74058.1 - 3.7 5.9 7.7 5.8 5.3 7.7 1.2 1 0 0 1 1 1 0 Cellulose synthase CPSF100_C PF13299.6 CDI74058.1 - 4.9 7.3 22.0 6.1 7.0 18.9 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Nucleoside_tran PF01733.18 CDI74058.1 - 5.2 6.3 10.6 1.7 8.0 7.2 1.9 2 0 0 2 2 2 0 Nucleoside transporter Rgp1 PF08737.10 CDI74058.1 - 5.4 6.1 24.1 9.7 5.2 24.1 1.3 1 0 0 1 1 1 0 Rgp1 GREB1 PF15782.5 CDI74058.1 - 5.9 3.9 28.7 8.9 3.3 28.7 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LAP1C PF05609.12 CDI74058.1 - 8.2 5.4 36.7 1.1 8.3 32.5 1.6 2 0 0 2 2 1 0 Lamina-associated polypeptide 1C (LAP1C) Dicty_REP PF05086.12 CDI74058.1 - 9 4.1 13.0 11 3.8 13.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Plasmodium_Vir PF05795.11 CDI74058.1 - 9.3 5.6 11.2 15 4.9 11.2 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Trypan_PARP PF05887.11 CDI74059.1 - 0.021 14.8 22.1 0.068 13.2 21.7 1.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF4407 PF14362.6 CDI74059.1 - 0.031 13.6 12.7 0.04 13.3 12.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SAPS PF04499.15 CDI74059.1 - 0.19 10.5 16.2 0.27 10.0 16.2 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Peptidase_S64 PF08192.11 CDI74059.1 - 2.7 6.4 18.7 3.6 6.0 18.7 1.2 1 0 0 1 1 1 0 Peptidase family S64 DNA_pol_phi PF04931.13 CDI74059.1 - 7.9 4.4 27.0 13 3.8 27.0 1.4 1 0 0 1 1 1 0 DNA polymerase phi DUF2828 PF11443.8 CDI74060.1 - 0.88 7.6 22.2 0.92 7.5 22.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF2052 PF09747.9 CDI74060.1 - 2.8 8.0 27.6 3.2 7.8 27.6 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PCNP PF15473.6 CDI74060.1 - 4.3 8.1 16.2 5.2 7.8 16.2 1.2 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family AUX_IAA PF02309.16 CDI74060.1 - 4.3 7.1 18.5 5 6.9 18.5 1.0 1 0 0 1 1 1 0 AUX/IAA family FAM60A PF15396.6 CDI74060.1 - 6.6 6.7 22.5 7.9 6.4 22.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF913 PF06025.12 CDI74060.1 - 8 5.3 14.8 10 5.0 14.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2722 PF10846.8 CDI74062.1 - 0.002 17.1 6.0 0.002 17.1 6.0 11.1 5 4 4 10 10 10 1 Protein of unknown function (DUF2722) APG6_N PF17675.1 CDI74063.1 - 2.2 8.8 64.0 0.095 13.2 9.1 3.8 2 1 1 3 3 3 0 Apg6 coiled-coil region Scaffolding_pro PF11418.8 CDI74063.1 - 4.9 7.8 15.0 25 5.5 8.4 3.1 2 1 1 3 3 3 0 Phi29 scaffolding protein Fez1 PF06818.15 CDI74063.1 - 6.4 7.2 46.3 3.5 8.0 5.1 2.2 2 0 0 2 2 2 0 Fez1 MFS_1 PF07690.16 CDI74064.1 - 1.4e-33 116.3 33.1 1.1e-29 103.6 21.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDI74064.1 - 1.1e-06 27.8 8.3 1.1e-06 27.8 8.3 2.5 2 1 1 3 3 3 2 Sugar (and other) transporter MFS_1_like PF12832.7 CDI74064.1 - 0.036 12.9 8.6 0.091 11.6 8.6 1.7 1 1 0 1 1 1 0 MFS_1 like family DnaJ PF00226.31 CDI74065.1 - 1e-25 89.6 0.5 1.6e-25 89.0 0.5 1.3 1 0 0 1 1 1 1 DnaJ domain Caldesmon PF02029.15 CDI74067.1 - 0.28 9.9 65.6 0.23 10.2 14.6 2.3 2 0 0 2 2 2 0 Caldesmon BPD_transp_2 PF02653.16 CDI74068.1 - 0.006 15.8 0.2 0.0096 15.1 0.2 1.3 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component Dapper PF15268.6 CDI74068.1 - 3.4 6.4 57.9 4.4 6.0 57.9 1.3 1 0 0 1 1 1 0 Dapper CDC27 PF09507.10 CDI74068.1 - 5.2 6.3 57.6 7.9 5.7 57.6 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Activator_LAG-3 PF11498.8 CDI74069.1 - 2.6e-06 26.7 23.3 2.6e-06 26.7 23.3 13.5 11 3 2 14 14 14 1 Transcriptional activator LAG-3 SR-25 PF10500.9 CDI74069.1 - 0.00031 20.4 46.0 0.00056 19.6 16.8 17.9 10 4 10 20 20 20 5 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI74070.1 - 0.0068 16.0 27.1 0.0068 16.0 27.1 15.6 4 2 6 10 10 10 2 Spt20 family RAP PF08373.10 CDI74071.1 - 2.3e-08 34.0 0.0 3.4e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 RAP domain BRCC36_C PF18110.1 CDI74072.1 - 0.0045 17.1 1.1 0.048 13.8 0.9 2.9 2 0 0 2 2 2 1 BRCC36 C-terminal helical domain Kinesin PF00225.23 CDI74073.1 - 1.9e-97 326.2 2.7 1.6e-65 221.2 0.3 2.1 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 CDI74073.1 - 7.9e-21 74.6 0.2 2.1e-17 63.4 0.0 2.6 1 1 1 2 2 2 2 Microtubule binding RE_Bsp6I PF09504.10 CDI74073.1 - 0.0011 18.6 0.1 1.3 8.6 0.0 2.4 2 0 0 2 2 2 2 Bsp6I restriction endonuclease LIM_bind PF01803.16 CDI74073.1 - 0.021 14.4 1.3 2.8 7.4 0.1 3.0 2 1 0 2 2 2 0 LIM-domain binding protein CaM-KIIN PF15170.6 CDI74073.1 - 0.037 14.2 0.0 8.3 6.6 0.0 2.7 2 0 0 2 2 2 0 Calcium/calmodulin-dependent protein kinase II inhibitor AAA_22 PF13401.6 CDI74073.1 - 0.04 14.2 0.1 1.8 8.8 0.0 3.1 3 0 0 3 3 3 0 AAA domain DUF2722 PF10846.8 CDI74074.1 - 0.0002 20.5 12.8 0.00025 20.2 12.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI74074.1 - 0.00062 19.4 16.4 0.00081 19.1 16.4 1.2 1 0 0 1 1 1 1 Spt20 family Bindin PF02084.15 CDI74074.1 - 0.0036 17.6 10.2 0.0044 17.3 10.2 1.1 1 0 0 1 1 1 1 Bindin TFIIA PF03153.13 CDI74074.1 - 0.0079 16.2 17.0 0.009 16.1 17.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CDI74074.1 - 0.021 14.4 6.5 0.026 14.1 6.5 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Plasmodium_Vir PF05795.11 CDI74074.1 - 0.26 10.7 4.8 0.28 10.5 4.8 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SARAF PF06682.12 CDI74074.1 - 0.53 9.9 11.7 0.67 9.5 11.7 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Presenilin PF01080.17 CDI74074.1 - 1.1 8.0 8.9 1.3 7.7 8.9 1.1 1 0 0 1 1 1 0 Presenilin MRI PF15325.6 CDI74074.1 - 1.3 10.1 6.0 2.3 9.4 0.4 2.2 2 0 0 2 2 2 0 Modulator of retrovirus infection GRP PF07172.11 CDI74074.1 - 3 8.6 8.7 4.9 7.9 8.7 1.3 1 0 0 1 1 1 0 Glycine rich protein family GREB1 PF15782.5 CDI74074.1 - 4.9 4.2 11.0 5.4 4.0 11.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DivIC PF04977.15 CDI74074.1 - 5.7 6.8 15.0 11 5.8 15.0 1.5 1 0 0 1 1 1 0 Septum formation initiator FCP1_C PF09309.10 CDI74074.1 - 6.3 6.6 15.5 10 5.9 15.5 1.3 1 1 0 1 1 1 0 FCP1, C-terminal DUF1980 PF09323.10 CDI74074.1 - 7.2 6.5 6.7 5.4 6.9 4.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Cir_N PF10197.9 CDI74075.1 - 1.3e-11 44.5 10.8 1.3e-11 44.5 10.8 4.2 3 1 1 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR DEAD PF00270.29 CDI74076.1 - 3.7e-28 98.5 0.0 3.9e-27 95.1 0.0 2.5 2 1 1 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI74076.1 - 4.7e-16 59.1 0.0 1.4e-15 57.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HTH_53 PF18606.1 CDI74076.1 - 0.061 13.0 0.0 0.23 11.1 0.0 2.0 1 0 0 1 1 1 0 Zap helix turn helix N-terminal domain CSRNP_N PF16019.5 CDI74076.1 - 9.7 6.0 7.6 20 5.0 7.6 1.4 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus EF-hand_6 PF13405.6 CDI74077.1 - 6.9e-11 41.2 0.0 0.00016 21.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 CDI74077.1 - 7.7e-11 42.3 0.1 0.00012 22.5 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDI74077.1 - 1.8e-09 36.5 0.0 0.0026 17.2 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 CDI74077.1 - 2.1e-06 27.9 0.2 0.1 13.0 0.0 3.3 3 1 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 CDI74077.1 - 1.1e-05 25.2 0.0 0.012 15.5 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 CDI74077.1 - 0.0033 16.8 0.0 1.6 8.4 0.0 2.5 2 0 0 2 2 2 2 EF hand BRCT_2 PF16589.5 CDI74078.1 - 0.0097 16.3 0.0 0.02 15.3 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain EFG_II PF14492.6 CDI74082.1 - 0.0044 17.1 0.0 0.0081 16.2 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 CDI74082.1 - 0.036 14.5 0.0 0.48 10.9 0.0 2.4 1 1 0 1 1 1 0 Elongation factor Tu domain 2 EFG_C PF00679.24 CDI74082.1 - 0.078 13.0 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Elongation factor G C-terminus RCDG1 PF15725.5 CDI74082.1 - 0.11 12.9 9.5 0.14 12.6 1.2 2.8 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein Trypan_PARP PF05887.11 CDI74083.1 - 0.3 11.1 88.3 45 4.0 30.0 3.3 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF3682 PF12446.8 CDI74084.1 - 0.044 14.3 4.1 0.044 14.3 4.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) Metallophos PF00149.28 CDI74085.1 - 1.4e-31 110.6 0.1 2.1e-31 110.0 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 CDI74085.1 - 4.7e-16 58.9 0.0 1.3e-15 57.4 0.0 1.8 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_2 PF07719.17 CDI74085.1 - 1e-14 53.3 4.1 0.00082 19.3 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDI74085.1 - 1.8e-11 43.3 3.8 0.011 15.6 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDI74085.1 - 1.5e-05 25.1 1.5 0.0038 17.5 0.4 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDI74085.1 - 3.1e-05 23.6 1.0 0.015 15.0 0.3 3.0 2 1 0 2 2 2 2 TPR repeat TPR_8 PF13181.6 CDI74085.1 - 0.00018 21.5 0.6 0.12 12.7 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDI74085.1 - 0.00034 20.7 0.0 0.00082 19.5 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI74085.1 - 0.0006 20.4 1.4 3.9 8.5 0.0 4.0 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDI74085.1 - 0.045 14.2 0.5 0.21 12.0 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDI74085.1 - 0.054 14.0 2.2 31 5.2 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat bPH_4 PF06713.11 CDI74085.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial PH domain TPR_16 PF13432.6 CDI74085.1 - 0.16 12.6 3.7 3.9 8.2 0.0 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat SelP_N PF04592.14 CDI74086.1 - 0.87 8.9 13.8 1.7 8.0 13.8 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF3984 PF13136.6 CDI74086.1 - 0.93 8.8 17.4 0.12 11.8 12.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3984) Spt20 PF12090.8 CDI74087.1 - 2.6e-08 33.8 28.9 5.9e-05 22.8 7.9 2.3 2 0 0 2 2 2 2 Spt20 family RskA PF10099.9 CDI74087.1 - 4.8e-05 23.7 53.1 0.0023 18.3 11.5 3.1 2 1 0 2 2 2 1 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI74087.1 - 0.00014 21.0 3.1 0.00014 21.0 3.1 2.5 2 1 0 2 2 1 1 Protein of unknown function (DUF2722) tRNA-synt_2 PF00152.20 CDI74087.1 - 0.00026 20.2 0.1 0.00035 19.7 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) SUIM_assoc PF16619.5 CDI74087.1 - 0.0019 18.2 0.9 0.0019 18.2 0.9 4.2 3 1 0 3 3 1 1 Unstructured region C-term to UIM in Ataxin3 DUF1645 PF07816.11 CDI74087.1 - 0.0022 18.6 5.5 0.0022 18.6 5.5 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF1645) BORG_CEP PF14957.6 CDI74087.1 - 0.03 15.5 11.3 0.13 13.5 6.1 2.3 2 0 0 2 2 2 0 Cdc42 effector DUF4570 PF15134.6 CDI74087.1 - 0.12 12.4 17.2 1.5 8.9 7.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) Slu7 PF11708.8 CDI74087.1 - 0.62 9.8 16.6 0.14 11.9 3.2 2.3 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor SPOUT_MTase PF02590.17 CDI74087.1 - 0.84 9.6 7.6 0.19 11.7 1.4 2.2 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase Macoilin PF09726.9 CDI74087.1 - 1.2 7.6 23.2 0.35 9.4 13.8 2.3 2 0 0 2 2 2 0 Macoilin family Pet20 PF08692.10 CDI74087.1 - 1.3 9.8 7.3 7.8 7.2 1.4 2.3 2 0 0 2 2 2 0 Mitochondrial protein Pet20 FAM60A PF15396.6 CDI74087.1 - 2.8 7.9 13.3 1.9 8.4 0.7 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Diacid_rec PF05651.13 CDI74087.1 - 2.9 7.6 7.9 4.7 6.9 1.1 2.5 2 0 0 2 2 2 0 Putative sugar diacid recognition MPM1 PF17234.2 CDI74087.1 - 3.4 7.9 22.0 1.2 9.4 3.3 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 eIF-3_zeta PF05091.12 CDI74087.1 - 3.6 6.5 17.1 0.12 11.3 5.4 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI74087.1 - 4.3 7.2 52.1 3.8 7.4 23.9 2.1 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF1635 PF07795.11 CDI74087.1 - 5.7 6.7 25.9 3.5 7.4 16.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) MDM1 PF15501.6 CDI74087.1 - 6.5 5.8 25.1 0.69 9.0 13.3 2.2 2 0 0 2 2 2 0 Nuclear protein MDM1 MscS_TM PF12794.7 CDI74087.1 - 7.2 5.4 16.2 0.24 10.2 2.1 2.6 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 BUD22 PF09073.10 CDI74087.1 - 7.3 5.8 25.8 6.2e+02 -0.5 20.3 2.1 1 1 0 1 1 1 0 BUD22 DUF4667 PF15700.5 CDI74087.1 - 9.7 6.2 25.0 9.4 6.2 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) Band_3_cyto PF07565.13 CDI74087.1 - 9.7 5.9 14.8 2.9 7.6 1.0 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain PPL5 PF18168.1 CDI74088.1 - 0.7 9.1 18.8 0.94 8.7 18.8 1.3 1 0 0 1 1 1 0 Prim-pol family 5 NARP1 PF12569.8 CDI74088.1 - 2.4 7.0 30.3 2.8 6.7 30.3 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Phage_GPO PF05929.11 CDI74088.1 - 3.3 7.3 33.4 3.6 7.1 33.4 1.0 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase V_ATPase_I PF01496.19 CDI74088.1 - 4.7 5.0 32.5 6.5 4.5 32.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI74088.1 - 5.4 5.9 26.7 6.8 5.6 26.7 1.1 1 0 0 1 1 1 0 CLN3 protein FAM60A PF15396.6 CDI74088.1 - 5.8 6.9 29.0 6 6.8 29.0 1.0 1 0 0 1 1 1 0 Protein Family FAM60A PPP4R2 PF09184.11 CDI74088.1 - 5.9 6.4 19.8 6.7 6.2 19.8 1.0 1 0 0 1 1 1 0 PPP4R2 Presenilin PF01080.17 CDI74088.1 - 7.8 5.2 42.4 8.2 5.1 42.4 1.0 1 0 0 1 1 1 0 Presenilin TCP PF03634.13 CDI74088.1 - 9.2 6.8 31.9 12 6.4 31.9 1.2 1 0 0 1 1 1 0 TCP family transcription factor HATPase_c_5 PF14501.6 CDI74089.1 - 0.055 13.4 0.0 0.055 13.4 0.0 2.2 2 0 0 2 2 2 0 GHKL domain Clathrin_lg_ch PF01086.17 CDI74090.1 - 2.2e-05 24.7 45.2 4.9e-05 23.5 45.2 1.7 1 1 0 1 1 1 1 Clathrin light chain PAT1 PF09770.9 CDI74090.1 - 0.89 7.7 35.7 1.1 7.4 35.7 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI74090.1 - 4.2 4.4 30.4 6.2 3.8 30.4 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FYVE PF01363.21 CDI74091.1 - 1.9e-16 59.9 11.1 1.9e-16 59.9 11.1 3.2 3 0 0 3 3 3 1 FYVE zinc finger Spt20 PF12090.8 CDI74091.1 - 2.4e-06 27.3 106.0 7.8e-05 22.4 18.1 6.2 6 0 0 6 6 6 4 Spt20 family DUF2722 PF10846.8 CDI74091.1 - 1.5 7.7 90.6 0.07 12.1 1.7 5.9 5 0 0 5 5 5 0 Protein of unknown function (DUF2722) Utp14 PF04615.13 CDI74091.1 - 3.9 5.9 0.0 3.9 5.9 0.0 5.3 4 2 0 4 4 4 0 Utp14 protein Utp14 PF04615.13 CDI74092.1 - 6.6e-07 28.3 4.1 6.6e-07 28.3 4.1 9.0 4 3 2 7 7 7 1 Utp14 protein DUF2339 PF10101.9 CDI74092.1 - 1.6e-05 23.7 8.2 1.6e-05 23.7 8.2 7.0 2 2 3 5 5 5 1 Predicted membrane protein (DUF2339) BUD22 PF09073.10 CDI74092.1 - 0.00011 21.7 0.2 0.00011 21.7 0.2 10.6 6 3 1 9 9 9 2 BUD22 DUF2722 PF10846.8 CDI74092.1 - 0.00028 20.0 7.5 0.00028 20.0 7.5 20.8 17 5 3 20 20 20 8 Protein of unknown function (DUF2722) RskA PF10099.9 CDI74092.1 - 0.00047 20.5 0.4 0.00047 20.5 0.4 27.9 4 4 11 19 19 19 5 Anti-sigma-K factor rskA RskA PF10099.9 CDI74093.1 - 0.012 15.9 0.4 0.015 15.6 0.4 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF4175 PF13779.6 CDI74093.1 - 0.015 13.2 15.3 0.019 12.9 15.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SHR3_chaperone PF08229.11 CDI74093.1 - 0.41 9.6 4.7 0.67 8.9 4.7 1.3 1 0 0 1 1 1 0 ER membrane protein SH3 TMEM208_SND2 PF05620.11 CDI74093.1 - 3.2 7.5 7.8 10 5.9 7.8 1.9 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 Apt1 PF10351.9 CDI74094.1 - 0.065 12.1 0.0 0.076 11.9 0.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain 2OG-FeII_Oxy_3 PF13640.6 CDI74095.1 - 8.8e-06 26.5 0.0 0.00024 21.9 0.0 2.3 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Penaeidin PF05927.11 CDI74095.1 - 2.4 9.0 5.8 41 5.0 0.1 3.2 3 0 0 3 3 3 0 Penaeidin Arf PF00025.21 CDI74097.1 - 2.9e-30 105.0 0.0 3.6e-30 104.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 CDI74097.1 - 0.00012 21.7 0.0 0.00015 21.4 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 CDI74097.1 - 0.00059 19.3 0.0 0.0063 16.0 0.0 2.0 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CDI74097.1 - 0.018 15.3 0.0 0.029 14.6 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 CDI74097.1 - 0.17 11.6 0.0 0.41 10.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain Band_7 PF01145.25 CDI74098.1 - 7.2e-28 97.8 1.3 8.5e-28 97.6 0.0 1.7 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 CDI74098.1 - 3.1e-20 72.0 0.1 8e-20 70.7 0.1 1.8 1 0 0 1 1 1 1 C-terminal region of band_7 Band_7_1 PF13421.6 CDI74098.1 - 0.012 15.4 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family RskA PF10099.9 CDI74099.1 - 0.004 17.5 10.9 0.004 17.5 10.9 15.1 2 2 6 9 9 9 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI74101.1 - 0.00075 19.2 8.2 0.00075 19.2 8.2 17.8 11 5 6 19 19 19 4 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI74101.1 - 0.0068 16.7 14.3 0.0068 16.7 14.3 25.7 2 2 15 18 18 18 4 Anti-sigma-K factor rskA ERCC4 PF02732.15 CDI74102.1 - 0.002 18.4 18.6 0.002 18.4 18.6 5.2 3 2 0 3 3 3 1 ERCC4 domain Apt1 PF10351.9 CDI74102.1 - 0.0031 16.4 10.4 0.0031 16.4 10.4 5.4 3 1 1 5 5 5 1 Golgi-body localisation protein domain SR-25 PF10500.9 CDI74103.1 - 0.14 11.8 29.2 0.54 9.8 1.2 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Tic110 PF16940.5 CDI74103.1 - 0.39 9.2 7.3 0.44 9.0 7.3 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter Ribosomal_60s PF00428.19 CDI74103.1 - 0.79 10.3 13.6 1.7 9.2 13.6 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Spc7 PF08317.11 CDI74104.1 - 0.0096 14.8 58.5 0.012 14.5 58.5 1.0 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF3552 PF12072.8 CDI74104.1 - 0.15 11.4 73.6 0.056 12.9 37.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Exonuc_VII_L PF02601.15 CDI74104.1 - 0.53 9.8 60.1 0.72 9.4 60.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit YabA PF06156.13 CDI74104.1 - 5.8 7.6 50.2 4.8 7.9 23.7 2.0 1 1 1 2 2 2 0 Initiation control protein YabA V_ATPase_I PF01496.19 CDI74104.1 - 6.1 4.6 47.5 7 4.4 47.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ERM PF00769.19 CDI74104.1 - 7.7 6.2 65.7 14 5.4 65.7 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family SDA1 PF05285.12 CDI74106.1 - 5.2 6.4 40.4 6.7 6.0 40.4 1.1 1 0 0 1 1 1 0 SDA1 RPN2_C PF18004.1 CDI74108.1 - 0.058 13.3 11.1 0.061 13.2 11.1 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF5523 PF17661.1 CDI74108.1 - 0.066 12.9 18.5 0.067 12.9 18.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) CPSF100_C PF13299.6 CDI74108.1 - 0.11 12.7 7.8 0.12 12.6 7.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal EIIBC-GUT_N PF03612.14 CDI74108.1 - 0.27 10.9 3.2 0.31 10.8 3.2 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF2722 PF10846.8 CDI74108.1 - 0.3 10.0 9.9 0.32 9.9 9.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Connexin PF00029.19 CDI74108.1 - 0.31 10.8 5.0 0.33 10.7 5.0 1.1 1 0 0 1 1 1 0 Connexin GNAT_acetyltr_2 PF13718.6 CDI74108.1 - 0.47 9.8 4.7 0.53 9.7 4.7 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 RPA43_OB PF17875.1 CDI74108.1 - 0.48 11.1 8.1 0.63 10.7 8.1 1.3 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I DUF4637 PF15470.6 CDI74108.1 - 0.53 10.0 23.6 0.64 9.7 23.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) PI3K_1B_p101 PF10486.9 CDI74108.1 - 0.54 8.0 12.2 0.58 7.9 12.2 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF719 PF05334.13 CDI74108.1 - 0.57 10.3 8.1 0.69 10.1 8.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF719) DUF2052 PF09747.9 CDI74108.1 - 0.71 10.0 22.5 0.94 9.6 22.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF3306 PF11748.8 CDI74108.1 - 0.74 10.7 9.8 0.77 10.6 9.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) FYDLN_acid PF09538.10 CDI74108.1 - 0.76 10.5 20.0 0.91 10.2 20.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Mpp10 PF04006.12 CDI74108.1 - 0.84 8.0 25.4 0.84 8.0 25.4 1.0 1 0 0 1 1 1 0 Mpp10 protein TRAP_alpha PF03896.16 CDI74108.1 - 0.89 8.7 15.7 0.95 8.6 15.7 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4471 PF14740.6 CDI74108.1 - 1 8.5 5.6 1 8.5 5.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) CKAP2_C PF15297.6 CDI74108.1 - 1 8.3 10.6 1.1 8.2 10.6 1.0 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus ORC_WH_C PF18137.1 CDI74108.1 - 1.1 9.4 10.6 1.2 9.2 10.6 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal SDA1 PF05285.12 CDI74108.1 - 1.1 8.6 27.6 1.2 8.5 27.6 1.0 1 0 0 1 1 1 0 SDA1 Paf1 PF03985.13 CDI74108.1 - 1.2 8.1 28.7 1.3 8.0 28.7 1.0 1 0 0 1 1 1 0 Paf1 PAF PF15715.5 CDI74108.1 - 1.2 9.8 11.5 1.3 9.6 11.5 1.1 1 0 0 1 1 1 0 PCNA-associated factor histone like domain RR_TM4-6 PF06459.12 CDI74108.1 - 1.2 8.9 14.9 1.2 8.9 14.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Prothymosin PF03247.14 CDI74108.1 - 1.2 9.7 38.4 1.8 9.0 38.4 1.3 1 0 0 1 1 1 0 Prothymosin/parathymosin family Zip PF02535.22 CDI74108.1 - 1.2 8.2 7.5 1.3 8.2 7.5 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Pox_Ag35 PF03286.14 CDI74108.1 - 1.3 8.8 19.6 1.5 8.6 19.6 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF2457 PF10446.9 CDI74108.1 - 1.3 8.1 32.9 1.5 7.8 32.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TFB6 PF17110.5 CDI74108.1 - 1.4 8.7 12.7 1.5 8.5 12.7 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Afi1 PF07792.12 CDI74108.1 - 1.4 9.4 10.3 1.6 9.3 10.3 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Trypan_PARP PF05887.11 CDI74108.1 - 1.6 8.7 19.9 1.8 8.6 19.9 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Vfa1 PF08432.10 CDI74108.1 - 1.6 9.0 12.2 1.7 9.0 12.2 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DNA_pol_phi PF04931.13 CDI74108.1 - 1.8 6.5 34.8 1.8 6.5 34.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi BUD22 PF09073.10 CDI74108.1 - 2 7.7 22.8 2.1 7.6 22.8 1.0 1 0 0 1 1 1 0 BUD22 SpoIIP PF07454.11 CDI74108.1 - 2.1 7.7 11.8 2.2 7.7 11.8 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RNA_pol_Rpc4 PF05132.14 CDI74108.1 - 2.1 8.7 9.3 2.4 8.6 9.3 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 XAP5 PF04921.14 CDI74108.1 - 2.1 8.1 11.5 2.3 8.0 11.5 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator Eapp_C PF10238.9 CDI74108.1 - 2.8 8.0 8.0 3.1 7.9 8.0 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein CobT PF06213.12 CDI74108.1 - 2.9 7.2 27.5 3.2 7.1 27.5 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 CDI74108.1 - 3.3 5.9 22.4 3.4 5.9 22.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Fmp27 PF10344.9 CDI74108.1 - 3.3 5.7 9.6 3.3 5.7 9.6 1.0 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 Sigma70_ner PF04546.13 CDI74108.1 - 3.4 7.5 23.1 4.4 7.1 23.1 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF913 PF06025.12 CDI74108.1 - 3.6 6.5 9.2 3.7 6.4 9.2 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Tim54 PF11711.8 CDI74108.1 - 3.9 6.2 12.5 4.1 6.1 12.5 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Nop14 PF04147.12 CDI74108.1 - 3.9 5.5 30.2 4.4 5.4 30.2 1.0 1 0 0 1 1 1 0 Nop14-like family PPL5 PF18168.1 CDI74108.1 - 4.2 6.6 7.9 4.4 6.5 7.9 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Nop53 PF07767.11 CDI74108.1 - 4.4 6.6 25.2 4.6 6.5 25.2 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) MCM_bind PF09739.9 CDI74108.1 - 4.8 5.5 8.4 4.8 5.5 8.4 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Presenilin PF01080.17 CDI74108.1 - 5.5 5.6 9.7 6 5.5 9.7 1.0 1 0 0 1 1 1 0 Presenilin PDDEXK_6 PF04720.12 CDI74108.1 - 8.9 6.2 11.1 9.6 6.1 11.1 1.1 1 0 0 1 1 1 0 PDDEXK-like family of unknown function eIF-3c_N PF05470.12 CDI74108.1 - 8.9 4.5 11.9 9.7 4.4 11.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus NOA36 PF06524.12 CDI74108.1 - 9.1 5.5 25.9 12 5.1 25.9 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4746 PF15928.5 CDI74108.1 - 9.7 5.5 20.7 11 5.3 20.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Orbi_VP6 PF01516.16 CDI74108.1 - 9.9 5.6 13.6 11 5.4 13.6 1.0 1 0 0 1 1 1 0 Orbivirus helicase VP6 Wbp11 PF09429.10 CDI74110.1 - 1.2e-17 64.0 10.3 2e-17 63.3 10.3 1.2 1 0 0 1 1 1 1 WW domain binding protein 11 Alpha-2-MRAP_C PF06401.11 CDI74110.1 - 0.0062 16.5 1.9 0.009 16.0 1.9 1.2 1 0 0 1 1 1 1 Alpha-2-macroglobulin RAP, C-terminal domain NAM-associated PF14303.6 CDI74111.1 - 0.00044 21.0 0.6 0.00044 21.0 0.6 12.6 5 3 5 10 10 10 1 No apical meristem-associated C-terminal domain RskA PF10099.9 CDI74112.1 - 0.0006 20.2 4.5 0.0006 20.2 4.5 12.8 2 2 6 9 9 9 2 Anti-sigma-K factor rskA K_channel_TID PF07941.11 CDI74112.1 - 0.0042 17.5 12.5 0.0042 17.5 12.5 20.9 17 8 0 17 17 17 3 Potassium channel Kv1.4 tandem inactivation domain Suf PF05843.14 CDI74113.1 - 0.19 11.7 19.3 0.2 11.6 19.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) eIF-3_zeta PF05091.12 CDI74113.1 - 0.7 8.8 20.0 0.83 8.6 20.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RR_TM4-6 PF06459.12 CDI74113.1 - 1.3 8.8 20.8 1.6 8.5 20.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI74113.1 - 1.7 7.5 14.5 1.9 7.4 14.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF913 PF06025.12 CDI74113.1 - 3.1 6.7 8.2 3.2 6.6 8.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 CDI74113.1 - 3.1 6.5 23.1 3.4 6.3 23.1 1.0 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI74113.1 - 5.2 7.1 11.5 5.4 7.0 11.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Pex14_N PF04695.13 CDI74113.1 - 8.3 7.0 22.7 11 6.6 22.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region IBN_N PF03810.19 CDI74114.1 - 4.9e-11 42.4 0.0 9.8e-11 41.4 0.0 1.5 1 0 0 1 1 1 1 Importin-beta N-terminal domain TBCC PF07986.12 CDI74115.1 - 1.4e-14 53.9 0.6 1.4e-14 53.9 0.6 2.2 3 0 0 3 3 3 1 Tubulin binding cofactor C RskA PF10099.9 CDI74115.1 - 0.00054 20.3 7.6 0.00054 20.3 7.6 6.2 4 2 1 6 6 6 4 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI74115.1 - 0.0031 17.1 8.8 0.0031 17.1 8.8 5.2 5 0 0 5 5 5 1 Nuclear RNA-splicing-associated protein Lig_chan PF00060.26 CDI74115.1 - 0.13 12.1 1.6 53 3.6 0.0 3.6 3 1 0 3 3 3 0 Ligand-gated ion channel EOS1 PF12326.8 CDI74115.1 - 0.89 9.5 0.0 0.89 9.5 0.0 4.1 3 1 0 3 3 3 0 N-glycosylation protein Folate_carrier PF01770.18 CDI74115.1 - 1.1 7.9 5.5 20 3.8 0.0 3.3 3 0 0 3 3 3 0 Reduced folate carrier 7tm_1 PF00001.21 CDI74115.1 - 2.7 7.3 4.8 5 6.4 0.2 3.0 3 0 0 3 3 3 0 7 transmembrane receptor (rhodopsin family) MRNIP PF15749.5 CDI74115.1 - 4.5 8.0 36.9 2.2 9.0 0.2 5.0 5 0 0 5 5 5 0 MRN-interacting protein Cas1_AcylT PF07779.12 CDI74115.1 - 8 5.2 5.9 77 2.0 0.2 3.2 3 0 0 3 3 3 0 10 TM Acyl Transferase domain found in Cas1p GWT1 PF06423.12 CDI74115.1 - 9.3 6.4 8.4 16 5.6 0.4 3.7 4 0 0 4 4 4 0 GWT1 RT_RNaseH_2 PF17919.1 CDI74117.1 - 3.3e-13 49.5 1.7 4.2e-13 49.2 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI74117.1 - 7.2e-13 48.7 1.8 7.2e-13 48.7 1.8 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase TFIIA PF03153.13 CDI74117.1 - 4.3e-05 23.7 23.1 4.8e-05 23.5 23.1 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 CDI74117.1 - 0.25 11.1 14.0 0.39 10.5 14.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Menin PF05053.13 CDI74117.1 - 0.87 7.9 14.6 1.1 7.6 14.6 1.1 1 0 0 1 1 1 0 Menin Macoilin PF09726.9 CDI74117.1 - 1.9 6.9 26.0 2.3 6.7 26.0 1.1 1 0 0 1 1 1 0 Macoilin family DUF4407 PF14362.6 CDI74117.1 - 3.5 6.9 9.7 4.8 6.4 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Suf PF05843.14 CDI74117.1 - 3.9 7.4 16.6 6.1 6.7 16.6 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) GREB1 PF15782.5 CDI74117.1 - 4.4 4.3 27.8 5 4.1 27.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 CDI74117.1 - 5.3 5.9 18.4 6.7 5.6 18.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 CDI74117.1 - 7.5 5.2 22.8 12 4.6 22.8 1.4 1 0 0 1 1 1 0 Presenilin Pkinase PF00069.25 CDI74118.1 - 1.4e-32 113.1 7.1 6.5e-13 48.7 0.0 4.0 3 1 1 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI74118.1 - 4.4e-15 55.7 4.5 1.2e-06 28.0 3.9 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase SART-1 PF03343.13 CDI74118.1 - 0.2 10.2 31.7 0.055 12.0 28.1 1.7 2 0 0 2 2 2 0 SART-1 family CDC24_OB1 PF17246.2 CDI74119.1 - 0.016 15.3 5.0 0.025 14.7 5.0 1.2 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 1 DUF775 PF05603.12 CDI74119.1 - 0.49 9.9 15.4 0.55 9.7 15.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) PRC2_HTH_1 PF18118.1 CDI74119.1 - 0.78 10.6 8.5 0.9 10.4 8.5 1.2 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain UPF0524 PF15823.5 CDI74119.1 - 0.96 8.8 9.3 1 8.7 9.3 1.1 1 0 0 1 1 1 0 UPF0524 of C3orf70 TMEM237 PF15383.6 CDI74119.1 - 1.4 8.0 7.1 1.5 7.9 7.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 237 Rxt3 PF08642.10 CDI74119.1 - 2.5 8.9 8.3 2.6 8.9 8.3 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 PA26 PF04636.13 CDI74119.1 - 2.6 6.9 13.2 2.7 6.8 13.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PEX11 PF05648.14 CDI74119.1 - 2.9 7.3 7.8 3.2 7.2 7.8 1.1 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) DUF4710 PF15828.5 CDI74119.1 - 6.4 7.0 12.2 2.6 8.3 10.0 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4710) Het-C PF07217.11 CDI74119.1 - 7.8 4.9 11.5 8.4 4.8 11.5 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C EOS1 PF12326.8 CDI74119.1 - 9.3 6.1 6.6 8.8 6.2 6.6 1.2 1 0 0 1 1 1 0 N-glycosylation protein DUF2722 PF10846.8 CDI74120.1 - 0.00094 18.2 13.0 0.00098 18.2 13.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI74120.1 - 0.0027 17.4 16.6 0.0027 17.4 16.6 1.1 1 0 0 1 1 1 1 Spt20 family DUF908 PF06012.12 CDI74120.1 - 0.0094 15.4 5.1 0.011 15.2 5.1 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) TFIIA PF03153.13 CDI74120.1 - 0.018 15.0 14.3 0.018 15.0 14.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SRRM_C PF15230.6 CDI74120.1 - 0.024 15.2 2.0 0.037 14.6 2.0 1.4 1 0 0 1 1 1 0 Serine/arginine repetitive matrix protein C-terminus MMR1 PF08505.10 CDI74120.1 - 0.034 14.4 6.5 0.038 14.3 6.5 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Peptidase_S49_N PF08496.10 CDI74120.1 - 0.051 13.6 5.6 0.063 13.3 5.6 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal eIF-3_zeta PF05091.12 CDI74120.1 - 0.052 12.5 5.5 0.05 12.6 5.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4834 PF16118.5 CDI74120.1 - 0.093 13.7 7.2 0.13 13.3 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Androgen_recep PF02166.16 CDI74120.1 - 0.12 11.2 13.7 0.13 11.0 13.7 1.2 1 0 0 1 1 1 0 Androgen receptor Roughex PF06020.11 CDI74120.1 - 0.13 11.4 8.6 0.12 11.4 8.6 1.1 1 0 0 1 1 1 0 Drosophila roughex protein DUF1764 PF08576.10 CDI74120.1 - 0.14 13.1 5.4 0.2 12.6 5.4 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Presenilin PF01080.17 CDI74120.1 - 0.15 10.8 3.4 0.14 10.9 3.4 1.0 1 0 0 1 1 1 0 Presenilin DUF3408 PF11888.8 CDI74120.1 - 0.15 12.2 8.3 0.2 11.8 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) BT1 PF03092.16 CDI74120.1 - 0.26 9.5 1.3 0.27 9.4 1.3 1.0 1 0 0 1 1 1 0 BT1 family Suf PF05843.14 CDI74120.1 - 0.34 10.8 9.0 0.38 10.7 9.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TERB2 PF15101.6 CDI74120.1 - 0.4 10.7 7.3 0.46 10.5 7.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 GTA_holin_3TM PF11351.8 CDI74120.1 - 0.43 11.1 7.5 0.57 10.7 7.5 1.3 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release Activator_LAG-3 PF11498.8 CDI74120.1 - 0.97 8.3 23.3 1.2 8.0 23.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF4175 PF13779.6 CDI74120.1 - 1.1 7.1 16.9 1.2 6.9 16.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Ndc1_Nup PF09531.10 CDI74120.1 - 1.4 7.6 7.1 1.4 7.5 7.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PepSY_TM PF03929.16 CDI74120.1 - 1.6 8.4 4.5 1.8 8.2 4.5 1.1 1 0 0 1 1 1 0 PepSY-associated TM region DUF3464 PF11947.8 CDI74120.1 - 3.8 7.3 7.3 5 6.9 7.3 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 XRN_M PF17846.1 CDI74120.1 - 4.8 6.0 8.3 7.2 5.4 8.1 1.3 1 1 0 1 1 1 0 Xrn1 helical domain E_Pc_C PF06752.12 CDI74120.1 - 5 7.2 17.4 6.3 6.8 17.4 1.3 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus UPF0560 PF10577.9 CDI74120.1 - 6.8 5.1 11.6 7.6 4.9 11.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 AI-2E_transport PF01594.16 CDI74121.1 - 0.077 12.1 0.9 0.1 11.8 0.9 1.1 1 0 0 1 1 1 0 AI-2E family transporter Spt20 PF12090.8 CDI74121.1 - 0.97 9.0 13.1 1.2 8.7 13.1 1.1 1 0 0 1 1 1 0 Spt20 family DUF945 PF06097.11 CDI74121.1 - 9.6 5.2 18.6 3.4 6.7 13.8 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF945) AP2 PF00847.20 CDI74122.1 - 1.1e-07 32.0 4.1 1.7e-05 24.9 0.2 6.5 6 0 0 6 6 6 2 AP2 domain Spt20 PF12090.8 CDI74122.1 - 0.00029 20.5 4.5 0.00029 20.5 4.5 9.5 5 3 3 8 8 8 2 Spt20 family Activator_LAG-3 PF11498.8 CDI74122.1 - 0.0035 16.4 45.0 0.0035 16.4 45.0 8.7 7 2 0 8 8 8 3 Transcriptional activator LAG-3 RR_TM4-6 PF06459.12 CDI74123.1 - 7 6.4 42.4 8.6 6.1 42.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.13 CDI74125.1 - 0.00022 21.4 55.6 0.0003 20.9 55.6 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Auxin_canalis PF05703.11 CDI74125.1 - 0.0011 19.0 26.3 0.0014 18.6 26.3 1.2 1 0 0 1 1 1 1 Auxin canalisation WDCP PF15390.6 CDI74125.1 - 3.1 6.1 26.7 4.2 5.6 26.7 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family PAT1 PF09770.9 CDI74125.1 - 5.1 5.2 44.8 6.6 4.9 44.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SARAF PF06682.12 CDI74127.1 - 0.00035 20.3 1.2 0.00035 20.3 1.2 2.0 2 1 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis DUF2722 PF10846.8 CDI74127.1 - 0.00093 18.2 11.9 0.0014 17.7 11.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI74127.1 - 0.00094 19.3 11.0 0.0013 18.8 11.0 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI74127.1 - 0.0028 17.3 14.8 0.0045 16.6 14.8 1.2 1 0 0 1 1 1 1 Spt20 family Velvet PF11754.8 CDI74127.1 - 0.003 17.5 0.5 0.0054 16.7 0.5 1.4 1 0 0 1 1 1 1 Velvet factor CBP_BcsG PF11658.8 CDI74127.1 - 0.0083 14.6 4.7 0.014 13.8 4.7 1.3 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG Coilin_N PF15862.5 CDI74127.1 - 0.0083 15.9 0.3 0.022 14.6 0.1 1.7 2 0 0 2 2 2 1 Coilin N-terminus RCC1_2 PF13540.6 CDI74127.1 - 0.02 14.7 11.4 0.77 9.6 0.1 5.2 4 1 1 5 5 5 0 Regulator of chromosome condensation (RCC1) repeat Roughex PF06020.11 CDI74127.1 - 0.075 12.1 1.7 0.12 11.5 1.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein TMEM51 PF15345.6 CDI74127.1 - 0.12 12.2 4.9 0.085 12.7 1.2 2.4 2 0 0 2 2 2 0 Transmembrane protein 51 RskA PF10099.9 CDI74127.1 - 0.15 12.4 10.5 0.069 13.4 2.5 3.0 3 0 0 3 3 3 0 Anti-sigma-K factor rskA YfhO PF09586.10 CDI74127.1 - 0.15 10.3 14.3 0.21 9.8 14.3 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO CitMHS PF03600.16 CDI74127.1 - 0.26 10.5 11.5 0.45 9.7 11.5 1.9 1 1 0 1 1 1 0 Citrate transporter Pex14_N PF04695.13 CDI74127.1 - 0.42 11.2 12.8 1.2 9.8 12.8 1.8 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region BNIP3 PF06553.12 CDI74127.1 - 0.86 9.2 8.5 2 8.0 8.5 1.6 1 0 0 1 1 1 0 BNIP3 Activator_LAG-3 PF11498.8 CDI74127.1 - 2 7.3 21.1 2.9 6.7 21.1 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Suf PF05843.14 CDI74127.1 - 5.5 6.9 8.0 8.5 6.3 8.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) UPF0182 PF03699.13 CDI74127.1 - 9.1 4.3 7.5 15 3.5 7.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) DUF4460 PF14687.6 CDI74128.1 - 6e-11 42.4 11.1 1.3e-09 38.1 11.1 2.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4460) DUF2722 PF10846.8 CDI74128.1 - 0.0025 16.8 24.0 0.0052 15.8 6.4 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) ASD2 PF08687.11 CDI74128.1 - 0.0033 17.0 12.7 0.0041 16.7 12.7 1.2 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 tRNA_lig_CPD PF08302.11 CDI74128.1 - 0.045 13.2 9.4 0.15 11.4 1.8 2.2 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain DUF4449 PF14613.6 CDI74128.1 - 0.047 13.8 8.5 0.57 10.3 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4449) Neur_chan_memb PF02932.16 CDI74128.1 - 0.17 11.9 5.2 0.22 11.6 5.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CLN3 PF02487.17 CDI74128.1 - 0.19 10.8 5.4 0.24 10.4 5.4 1.2 1 0 0 1 1 1 0 CLN3 protein MPM1 PF17234.2 CDI74128.1 - 0.31 11.3 11.4 1.8 8.8 1.8 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 GET2 PF08690.10 CDI74128.1 - 0.6 9.7 14.2 0.91 9.1 14.2 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 V_ATPase_I PF01496.19 CDI74128.1 - 0.63 7.9 11.6 0.7 7.7 11.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_lid_9 PF17871.1 CDI74128.1 - 0.78 9.7 9.0 0.78 9.7 0.8 2.4 2 0 0 2 2 2 0 AAA lid domain CT_C_D PF02682.16 CDI74128.1 - 0.9 9.2 4.7 1.2 8.9 4.7 1.3 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D DUF4660 PF15559.6 CDI74128.1 - 1.2 9.5 6.5 3.1 8.2 1.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4660) ALMT PF11744.8 CDI74128.1 - 1.3 7.8 8.9 1.5 7.5 8.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2489 PF10675.9 CDI74128.1 - 1.5 8.8 24.3 4.1 7.3 6.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) Exonuc_VII_L PF02601.15 CDI74128.1 - 1.5 8.3 13.5 1.9 7.9 13.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit FAM150 PF15129.6 CDI74128.1 - 3.4 7.8 11.1 4.5 7.5 2.4 2.3 2 0 0 2 2 2 0 FAM150 family CAF20 PF17052.5 CDI74128.1 - 3.9 7.6 11.2 4.3 7.5 2.1 2.3 2 0 0 2 2 2 0 Cap associated factor RRP14 PF15459.6 CDI74128.1 - 4.2 8.0 13.8 6 7.5 4.4 2.5 2 0 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 FlaG PF03646.15 CDI74128.1 - 4.4 7.5 19.7 5.1 7.3 3.0 2.4 2 0 0 2 2 2 0 FlaG protein SARAF PF06682.12 CDI74128.1 - 4.7 6.8 9.6 6.5 6.3 9.6 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Ndc1_Nup PF09531.10 CDI74128.1 - 5.4 5.6 12.7 6.5 5.3 12.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CNDH2_N PF06278.11 CDI74128.1 - 6 7.1 13.9 11 6.3 4.4 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Dicty_REP PF05086.12 CDI74128.1 - 8.2 4.3 11.1 11 3.8 11.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TMEM51 PF15345.6 CDI74128.1 - 9.5 6.0 13.4 6.5 6.5 4.0 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 Rpp20 PF12328.8 CDI74128.1 - 9.8 6.1 18.9 1.3e+03 -0.8 19.0 2.2 1 1 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P CSRNP_N PF16019.5 CDI74129.1 - 0.021 14.7 6.3 0.028 14.4 6.3 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus SR-25 PF10500.9 CDI74129.1 - 0.031 13.9 10.1 0.043 13.4 10.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Hydin_ADK PF17213.3 CDI74129.1 - 0.15 12.3 17.8 0.18 12.0 17.8 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Tau95_N PF17682.1 CDI74129.1 - 0.15 12.2 8.7 0.29 11.3 8.7 1.5 1 1 0 1 1 1 0 Tau95 Triple barrel domain RskA PF10099.9 CDI74129.1 - 0.18 12.1 16.4 0.27 11.5 16.4 1.3 1 1 0 1 1 1 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI74129.1 - 0.23 11.4 33.9 0.24 11.4 33.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CbiD PF01888.17 CDI74129.1 - 0.31 10.3 3.1 0.35 10.1 3.1 1.2 1 0 0 1 1 1 0 CbiD FKS1_dom1 PF14288.6 CDI74129.1 - 0.53 10.6 5.0 0.68 10.3 5.0 1.1 1 0 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 Presenilin PF01080.17 CDI74129.1 - 1.2 7.8 13.5 1.4 7.7 13.5 1.1 1 0 0 1 1 1 0 Presenilin DUF4569 PF15133.6 CDI74129.1 - 1.7 8.3 15.5 1.8 8.2 15.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) DUF572 PF04502.13 CDI74129.1 - 1.9 8.0 11.8 2 8.0 11.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) PA26 PF04636.13 CDI74129.1 - 2.7 6.8 11.3 3.1 6.6 11.3 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF3881 PF12997.7 CDI74129.1 - 2.8 7.1 6.9 3.7 6.7 6.9 1.3 1 1 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3881) F-protein PF00469.20 CDI74129.1 - 3 7.4 7.9 3.6 7.1 7.9 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef RR_TM4-6 PF06459.12 CDI74129.1 - 4.3 7.1 11.4 5.2 6.8 11.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TMEM154 PF15102.6 CDI74129.1 - 4.3 7.2 6.6 13 5.7 6.6 1.8 1 1 0 1 1 1 0 TMEM154 protein family Ndc1_Nup PF09531.10 CDI74129.1 - 4.8 5.7 16.0 5.2 5.6 16.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Usp PF00582.26 CDI74129.1 - 5.3 7.5 7.2 2.8 8.4 5.7 1.3 1 1 0 1 1 1 0 Universal stress protein family DUF3752 PF12572.8 CDI74129.1 - 5.7 7.4 14.7 7.4 7.1 14.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) Zip PF02535.22 CDI74129.1 - 6.4 5.9 5.6 6.8 5.8 5.6 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter PAT1 PF09770.9 CDI74129.1 - 9.9 4.3 21.7 11 4.1 21.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 zf-RING_4 PF14570.6 CDI74130.1 - 2.8e-20 71.8 10.6 4.6e-20 71.1 10.6 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 CDI74130.1 - 1.1e-06 28.3 11.9 1.5e-06 28.0 10.0 2.0 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDI74130.1 - 0.0014 18.9 11.4 0.0024 18.2 11.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDI74130.1 - 0.0054 16.6 10.5 0.0098 15.8 10.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDI74130.1 - 0.024 14.5 11.0 0.67 9.9 4.9 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Rad50_zn_hook PF04423.14 CDI74130.1 - 0.06 13.2 5.0 1.2 9.0 1.7 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-UDP PF14569.6 CDI74130.1 - 0.13 12.4 3.0 0.3 11.2 3.0 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger Baculo_IE-1 PF05290.11 CDI74130.1 - 0.13 12.2 4.9 0.21 11.5 4.9 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) RRM_1 PF00076.22 CDI74130.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DZR PF12773.7 CDI74130.1 - 0.93 9.6 9.9 3.9 7.6 9.9 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_2 PF13923.6 CDI74130.1 - 3.4 7.6 11.9 6.6 6.7 11.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI74130.1 - 4.2 7.4 10.7 5.2 7.1 9.7 1.7 1 1 0 1 1 1 0 zinc-RING finger domain MPM1 PF17234.2 CDI74131.1 - 0.18 12.0 4.1 0.21 11.8 4.1 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 TFIIA PF03153.13 CDI74131.1 - 0.36 10.8 16.8 0.37 10.7 16.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF702 PF05142.12 CDI74131.1 - 1.4 9.4 5.3 1.7 9.1 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Activator_LAG-3 PF11498.8 CDI74131.1 - 7.5 5.4 33.5 8.5 5.2 33.5 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TERB2 PF15101.6 CDI74131.1 - 8.4 6.4 10.2 9.9 6.2 10.2 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Spt20 PF12090.8 CDI74131.1 - 8.5 5.9 19.2 11 5.6 19.2 1.2 1 0 0 1 1 1 0 Spt20 family Cation_ATPase PF13246.6 CDI74133.1 - 1.2e-10 41.3 0.1 2.7e-08 33.8 0.0 5.3 6 0 0 6 6 6 2 Cation transport ATPase (P-type) DUF2722 PF10846.8 CDI74133.1 - 0.001 18.1 10.6 0.001 18.1 10.6 12.5 7 2 4 11 11 11 3 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI74134.1 - 0.0051 16.5 11.1 0.0051 16.5 11.1 4.0 2 1 0 3 3 3 1 Spt20 family DUF2367 PF10164.9 CDI74134.1 - 0.021 15.3 3.0 0.021 15.3 3.0 3.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2367) DUF2407_C PF13373.6 CDI74134.1 - 0.76 10.0 0.0 0.76 10.0 0.0 3.2 3 1 0 3 3 3 0 DUF2407 C-terminal domain PIP5K PF01504.18 CDI74134.1 - 1.2 8.3 9.7 0.19 10.9 2.7 2.2 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2722 PF10846.8 CDI74135.1 - 0.00098 18.2 16.5 0.00098 18.2 16.5 9.1 5 2 2 8 8 8 3 Protein of unknown function (DUF2722) SDA1 PF05285.12 CDI74135.1 - 0.0012 18.4 3.3 0.0012 18.4 3.3 4.2 3 2 1 4 4 4 1 SDA1 PBP1_TM PF14812.6 CDI74135.1 - 0.0037 17.6 4.8 0.0037 17.6 4.8 4.5 4 0 0 4 4 4 1 Transmembrane domain of transglycosylase PBP1 at N-terminal LAP1C PF05609.12 CDI74135.1 - 0.0053 15.9 19.2 0.0053 15.9 19.2 4.7 3 1 1 4 4 4 1 Lamina-associated polypeptide 1C (LAP1C) Consortin_C PF15281.6 CDI74135.1 - 0.018 15.0 1.4 0.018 15.0 1.4 5.7 6 1 0 6 6 6 0 Consortin C-terminus DUF5589 PF17672.1 CDI74135.1 - 1.4 8.9 6.5 0.34 10.8 0.4 3.2 2 0 0 2 2 2 0 Family of unknown function (DUF5589) RAP1 PF07218.11 CDI74135.1 - 2.1 6.5 4.2 5.9 5.0 4.2 1.7 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Utp14 PF04615.13 CDI74135.1 - 5.9 5.3 68.9 0.18 10.4 9.7 3.4 3 0 0 3 3 3 0 Utp14 protein Peptidase_M13 PF01431.21 CDI74136.1 - 0.097 12.3 10.4 0.18 11.4 10.4 1.5 1 0 0 1 1 1 0 Peptidase family M13 DUF1980 PF09323.10 CDI74137.1 - 0.14 12.1 0.5 5.7 6.8 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Spt20 PF12090.8 CDI74137.1 - 0.68 9.5 11.2 1.5 8.4 11.2 1.6 1 0 0 1 1 1 0 Spt20 family XRN_N PF03159.18 CDI74137.1 - 0.81 9.1 7.0 28 4.0 0.0 2.4 2 0 0 2 2 2 0 XRN 5'-3' exonuclease N-terminus Adaptin_binding PF10199.9 CDI74137.1 - 0.83 10.3 19.5 0.065 13.8 4.6 3.6 3 1 0 3 3 3 0 Alpha and gamma adaptin binding protein p34 FAM176 PF14851.6 CDI74137.1 - 1 9.0 9.2 0.57 9.8 4.0 2.5 2 0 0 2 2 2 0 FAM176 family DUF2201_N PF13203.6 CDI74137.1 - 1.2 8.6 17.7 1.3 8.6 7.1 2.9 2 1 0 2 2 2 0 Putative metallopeptidase domain DUF4834 PF16118.5 CDI74137.1 - 2.5 9.1 8.1 0.4 11.7 2.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RACo_linker PF17650.1 CDI74137.1 - 3.7 7.5 8.0 1.9 8.4 0.1 3.8 4 1 0 4 4 4 0 RACo linker region Rx_N PF18052.1 CDI74137.1 - 3.8 7.9 19.3 0.46 10.8 1.1 4.4 3 1 0 3 3 3 0 Rx N-terminal domain DUF948 PF06103.11 CDI74137.1 - 3.9 7.8 7.9 6.1 7.2 0.4 4.1 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) NPR3 PF03666.13 CDI74137.1 - 5.9 5.6 10.9 0.19 10.5 3.7 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Glycos_transf_3 PF00591.21 CDI74138.1 - 0.014 15.0 1.2 0.027 14.1 1.2 1.5 1 0 0 1 1 1 0 Glycosyl transferase family, a/b domain Tau95 PF09734.9 CDI74139.1 - 2.2 9.1 9.8 3.4 8.5 0.4 3.5 4 1 0 4 4 4 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain WSD PF15613.6 CDI74139.1 - 2.8 8.5 5.8 11 6.5 0.1 3.4 2 1 1 3 3 3 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif UCR_Fe-S_N PF10399.9 CDI74139.1 - 3.4 7.1 5.6 5.9 6.3 1.0 2.8 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DUF2229 PF09989.9 CDI74139.1 - 3.8 7.1 7.3 13 5.4 0.0 3.4 2 1 2 4 4 4 0 CoA enzyme activase uncharacterised domain (DUF2229) PLU-1 PF08429.11 CDI74140.1 - 6.8e-18 64.9 5.1 1.7e-14 53.8 0.0 9.3 8 1 1 9 9 9 5 PLU-1-like protein CCDC53 PF10152.9 CDI74140.1 - 0.00065 20.1 4.0 0.00065 20.1 4.0 22.0 17 5 1 20 20 20 2 Subunit CCDC53 of WASH complex DUF572 PF04502.13 CDI74141.1 - 0.25 10.9 28.8 0.31 10.6 28.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Presenilin PF01080.17 CDI74141.1 - 0.76 8.5 39.5 0.89 8.3 39.5 1.0 1 0 0 1 1 1 0 Presenilin DUF4484 PF14831.6 CDI74141.1 - 0.76 9.8 23.5 0.94 9.5 23.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) Glyco_hydro_4C PF11975.8 CDI74141.1 - 0.87 9.6 11.3 1.1 9.3 11.3 1.1 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase C-terminal domain ALMT PF11744.8 CDI74141.1 - 1.6 7.5 27.4 2 7.2 27.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter MAT1 PF06391.13 CDI74141.1 - 2.8 7.7 44.6 3.9 7.3 44.6 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 SLC12 PF03522.15 CDI74141.1 - 2.8 6.9 36.9 3.3 6.6 36.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 CDI74141.1 - 2.8 7.9 26.4 4.3 7.3 26.4 1.3 1 0 0 1 1 1 0 Protein Family FAM60A AUX_IAA PF02309.16 CDI74141.1 - 6.3 6.6 25.6 9.1 6.1 25.6 1.2 1 0 0 1 1 1 0 AUX/IAA family CDC45 PF02724.14 CDI74141.1 - 6.4 4.9 28.0 7.4 4.7 28.0 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.6 CDI74141.1 - 7.3 6.1 30.8 8.9 5.8 30.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) cwf18 PF08315.12 CDI74141.1 - 7.9 7.1 32.0 10 6.8 32.0 1.1 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor CAML PF14963.6 CDI74141.1 - 8.9 6.3 15.2 9.3 6.3 15.2 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand CCSAP PF15748.5 CDI74141.1 - 9.3 6.3 37.5 11 6.0 37.5 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated RskA PF10099.9 CDI74142.1 - 0.011 16.0 24.8 0.011 16.0 24.8 10.9 2 2 2 6 6 6 0 Anti-sigma-K factor rskA Abhydro_lipase PF04083.16 CDI74142.1 - 0.016 14.8 0.7 14 5.4 0.0 3.8 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Pkinase PF00069.25 CDI74143.1 - 7.2e-08 32.1 0.0 7.2e-08 32.1 0.0 3.1 3 1 0 3 3 3 1 Protein kinase domain Ribosomal_60s PF00428.19 CDI74143.1 - 0.016 15.8 12.9 0.016 15.8 12.9 9.7 4 3 3 7 7 7 0 60s Acidic ribosomal protein TFIIB_C_1 PF18542.1 CDI74143.1 - 2.7 8.1 7.4 0.92 9.6 3.4 2.3 1 1 0 1 1 1 0 Transcription factor IIB C-terminal module 1 RskA PF10099.9 CDI74144.1 - 0.29 11.4 15.1 0.38 11.0 15.1 1.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Utp14 PF04615.13 CDI74144.1 - 0.74 8.3 15.4 0.68 8.4 15.4 1.1 1 0 0 1 1 1 0 Utp14 protein RIFIN PF02009.16 CDI74144.1 - 1.8 8.4 20.9 2.4 8.0 20.9 1.2 1 0 0 1 1 1 0 Rifin LRR_8 PF13855.6 CDI74145.1 - 0.0013 18.4 12.5 0.028 14.2 1.8 2.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CDI74145.1 - 0.022 15.2 19.8 4.1 8.0 6.9 3.1 2 1 0 3 3 3 0 Leucine Rich repeats (2 copies) CbiD PF01888.17 CDI74146.1 - 0.011 15.0 3.5 0.011 15.0 3.5 2.5 3 0 0 3 3 3 0 CbiD Trypan_PARP PF05887.11 CDI74146.1 - 0.15 12.0 27.1 0.11 12.5 9.6 2.8 2 1 1 3 3 3 0 Procyclic acidic repetitive protein (PARP) OTU PF02338.19 CDI74147.1 - 1.5e-14 54.5 0.0 1.5e-14 54.5 0.0 2.7 3 0 0 3 3 3 1 OTU-like cysteine protease RskA PF10099.9 CDI74147.1 - 0.012 16.0 9.6 0.012 16.0 9.6 3.4 2 1 0 2 2 2 0 Anti-sigma-K factor rskA DUF3275 PF11679.8 CDI74147.1 - 5.3 7.0 20.1 0.44 10.5 11.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) Vps53_N PF04100.12 CDI74149.1 - 1.6e-17 63.6 18.7 1.6e-17 63.6 18.7 4.8 3 2 0 3 3 3 1 Vps53-like, N-terminal BUD22 PF09073.10 CDI74149.1 - 1.2e-05 24.8 3.6 1.2e-05 24.8 3.6 3.8 1 1 2 3 3 3 1 BUD22 SR-25 PF10500.9 CDI74149.1 - 0.0018 17.9 8.7 0.0018 17.9 8.7 5.9 6 0 0 6 6 6 2 Nuclear RNA-splicing-associated protein Med15 PF09606.10 CDI74149.1 - 0.004 15.9 11.9 0.004 15.9 11.9 4.4 4 0 0 4 4 4 2 ARC105 or Med15 subunit of Mediator complex non-fungal DUF1840 PF08895.11 CDI74149.1 - 0.023 15.0 5.8 0.023 15.0 5.8 7.0 6 1 1 7 7 7 0 Domain of unknown function (DUF1840) Utp14 PF04615.13 CDI74149.1 - 0.038 12.6 55.1 0.0033 16.1 38.6 2.7 2 1 0 2 2 2 0 Utp14 protein eIF-3_zeta PF05091.12 CDI74149.1 - 1.3 7.9 70.8 0.03 13.3 3.7 4.2 4 0 0 4 4 4 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SR-25 PF10500.9 CDI74150.1 - 0.0047 16.6 18.1 0.0047 16.6 18.1 7.2 4 3 3 7 7 7 3 Nuclear RNA-splicing-associated protein MFAP1 PF06991.11 CDI74150.1 - 0.012 15.4 6.5 0.012 15.4 6.5 4.7 4 1 0 5 5 5 0 Microfibril-associated/Pre-mRNA processing PAT1 PF09770.9 CDI74151.1 - 0.23 9.7 55.0 0.27 9.4 55.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SOG2 PF10428.9 CDI74151.1 - 0.38 9.9 19.8 0.42 9.8 19.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein CDC45 PF02724.14 CDI74151.1 - 0.42 8.8 26.5 0.5 8.6 26.5 1.2 1 0 0 1 1 1 0 CDC45-like protein PNISR PF15996.5 CDI74151.1 - 0.8 9.9 40.1 1 9.6 40.1 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR GREB1 PF15782.5 CDI74151.1 - 0.9 6.6 29.1 1 6.4 29.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4045 PF13254.6 CDI74151.1 - 1.3 8.6 37.1 1.6 8.3 37.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SRP-alpha_N PF04086.13 CDI74151.1 - 1.4 8.8 33.7 2 8.2 33.7 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Lin-8 PF03353.15 CDI74151.1 - 2.7 7.5 43.6 3.4 7.2 43.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Apt1 PF10351.9 CDI74151.1 - 5.9 5.6 22.0 6.9 5.4 22.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF966 PF06136.13 CDI74151.1 - 6.2 6.4 25.6 7.3 6.2 25.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Raftlin PF15250.6 CDI74151.1 - 7.8 5.1 24.8 11 4.7 24.8 1.3 1 0 0 1 1 1 0 Raftlin FRB_dom PF08771.11 CDI74152.1 - 8.8e-05 22.8 0.2 8.8e-05 22.8 0.2 6.5 5 2 2 7 7 7 1 FKBP12-rapamycin binding domain eIF-5a PF01287.20 CDI74154.1 - 0.065 13.3 0.6 0.63 10.2 0.1 2.4 3 0 0 3 3 3 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold CAP PF00188.26 CDI74155.1 - 0.00014 22.7 0.2 0.00019 22.3 0.2 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CAP PF00188.26 CDI74156.1 - 7.3e-09 36.5 0.5 0.0018 19.1 0.1 2.4 2 0 0 2 2 2 2 Cysteine-rich secretory protein family Cofilin_ADF PF00241.20 CDI74157.1 - 5.1e-27 94.1 0.0 6.4e-27 93.8 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Glyco_transf_92 PF01697.27 CDI74157.1 - 0.038 13.7 0.0 0.044 13.4 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 92 HRG PF16954.5 CDI74158.1 - 0.055 13.9 1.2 0.055 13.9 1.2 2.6 2 1 0 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene Rtf2 PF04641.12 CDI74159.1 - 1.5e-48 165.4 1.7 3.9e-48 164.1 1.7 1.6 1 1 0 1 1 1 1 Rtf2 RING-finger Striatin PF08232.12 CDI74159.1 - 0.12 12.9 8.9 0.26 11.9 8.9 1.5 1 0 0 1 1 1 0 Striatin family MRI PF15325.6 CDI74159.1 - 0.38 11.9 7.6 1 10.5 7.6 1.7 1 0 0 1 1 1 0 Modulator of retrovirus infection DUF1180 PF06679.12 CDI74159.1 - 2 8.8 6.9 3.6 8.0 6.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Aconitase PF00330.20 CDI74160.1 - 5.4e-178 592.7 0.0 6.8e-178 592.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CDI74160.1 - 2.5e-41 141.1 0.0 4e-41 140.4 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain zf-RING_11 PF17123.5 CDI74161.1 - 5e-08 32.5 2.5 6.2e-08 32.2 0.9 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_2 PF13639.6 CDI74161.1 - 7.2e-06 26.2 0.9 1.6e-05 25.1 0.5 1.8 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 CDI74161.1 - 0.00033 20.6 0.2 0.00068 19.6 0.2 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDI74161.1 - 0.0024 17.8 0.4 0.005 16.8 0.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDI74161.1 - 0.068 13.0 1.0 0.15 11.9 1.0 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDI74161.1 - 0.071 13.0 0.4 0.13 12.2 0.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ribosomal_60s PF00428.19 CDI74162.1 - 2.7 8.6 17.9 1.1 9.8 0.4 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein GREB1 PF15782.5 CDI74162.1 - 3.9 4.5 57.8 4.6 4.2 57.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF1645 PF07816.11 CDI74163.1 - 0.024 15.2 17.6 0.024 15.2 17.6 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1645) FHIPEP PF00771.20 CDI74163.1 - 0.91 7.9 20.3 0.066 11.7 7.7 2.2 2 0 0 2 2 2 0 FHIPEP family V_ATPase_I PF01496.19 CDI74163.1 - 1.6 6.5 26.9 0.96 7.3 12.4 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family RskA PF10099.9 CDI74164.1 - 0.018 15.3 27.6 18 5.6 26.4 2.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA BNR_3 PF13859.6 CDI74164.1 - 0.024 14.0 3.3 0.029 13.7 3.3 1.1 1 0 0 1 1 1 0 BNR repeat-like domain SAGA-Tad1 PF12767.7 CDI74164.1 - 0.053 13.3 10.7 0.059 13.1 10.7 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF4407 PF14362.6 CDI74164.1 - 0.19 11.1 18.1 0.24 10.7 18.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TERB2 PF15101.6 CDI74164.1 - 0.31 11.1 17.2 0.82 9.7 2.6 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 SLC12 PF03522.15 CDI74164.1 - 0.33 9.9 10.4 0.39 9.7 10.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF5385 PF17359.2 CDI74164.1 - 0.46 10.0 10.1 1 8.9 2.7 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5385) DUF533 PF04391.12 CDI74164.1 - 0.62 9.6 24.8 0.28 10.7 11.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF533) CD20 PF04103.15 CDI74164.1 - 0.65 10.1 2.7 2.1 8.4 0.4 2.0 2 0 0 2 2 2 0 CD20-like family Activator_LAG-3 PF11498.8 CDI74164.1 - 1.3 7.9 55.1 1.7 7.5 55.1 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF2681 PF10883.8 CDI74164.1 - 1.3 9.5 31.8 5 7.6 11.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) MCU PF04678.13 CDI74164.1 - 1.9 8.5 12.8 1 9.4 4.2 2.2 2 0 0 2 2 2 0 Mitochondrial calcium uniporter TCP PF03634.13 CDI74164.1 - 4.2 7.9 17.2 3 8.4 2.1 2.2 2 0 0 2 2 2 0 TCP family transcription factor HemX PF04375.14 CDI74164.1 - 4.2 6.5 34.3 2.8 7.1 8.1 2.1 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Ribosomal_60s PF00428.19 CDI74164.1 - 4.6 7.9 11.2 9 7.0 11.2 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Peptidase_S64 PF08192.11 CDI74164.1 - 5 5.5 13.2 5.4 5.4 13.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 Band_3_cyto PF07565.13 CDI74164.1 - 5.4 6.7 13.3 1.6 8.5 0.6 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain GPHR_N PF12537.8 CDI74164.1 - 6 7.0 7.1 3.9 7.6 0.4 2.3 2 0 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal Ndc1_Nup PF09531.10 CDI74164.1 - 7.8 5.0 19.5 8.5 4.9 19.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DTHCT PF08070.11 CDI74165.1 - 0.49 11.1 19.3 0.14 12.9 15.8 1.7 1 1 1 2 2 2 0 DTHCT (NUC029) region IMUP PF15761.5 CDI74165.1 - 0.65 10.7 23.4 0.51 11.0 10.5 2.1 1 1 1 2 2 2 0 Immortalisation up-regulated protein SR-25 PF10500.9 CDI74165.1 - 6.6 6.3 36.7 35 3.9 36.7 1.8 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein zf-XS PF03470.14 CDI74165.1 - 7.9 6.8 8.9 2.7 8.3 2.6 2.5 1 1 1 2 2 2 0 XS zinc finger domain Sulf_transp PF04143.14 CDI74166.1 - 0.89 9.1 2.1 0.39 10.2 0.1 1.5 2 0 0 2 2 2 0 Sulphur transport Leu_Phe_trans PF03588.14 CDI74167.1 - 0.00048 19.7 0.2 0.0041 16.7 0.0 2.2 3 0 0 3 3 3 1 Leucyl/phenylalanyl-tRNA protein transferase DUF3169 PF11368.8 CDI74168.1 - 0.16 11.5 0.0 13 5.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) LMF1 PF06762.14 CDI74169.1 - 0.11 11.5 2.2 0.16 11.0 2.2 1.4 1 0 0 1 1 1 0 Lipase maturation factor Cyt_bd_oxida_II PF02322.15 CDI74169.1 - 0.24 10.7 16.9 0.02 14.3 10.4 1.9 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II 14-3-3 PF00244.20 CDI74170.1 - 0.0011 18.6 0.1 0.0011 18.6 0.1 3.0 4 0 0 4 4 4 1 14-3-3 protein LAP1C PF05609.12 CDI74170.1 - 0.12 11.4 29.9 0.27 10.3 19.6 2.2 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Hamartin PF04388.12 CDI74170.1 - 0.36 9.4 26.4 0.088 11.5 17.8 2.0 2 0 0 2 2 2 0 Hamartin protein GREB1 PF15782.5 CDI74170.1 - 0.47 7.5 30.7 0.036 11.2 22.9 2.0 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer CDC45 PF02724.14 CDI74170.1 - 0.48 8.6 24.9 1.2 7.3 15.3 2.2 2 0 0 2 2 2 0 CDC45-like protein PNISR PF15996.5 CDI74170.1 - 0.7 10.1 33.4 0.26 11.5 18.7 2.5 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR SDA1 PF05285.12 CDI74170.1 - 3.2 7.1 31.0 0.12 11.8 18.2 2.1 2 0 0 2 2 2 0 SDA1 SAPS PF04499.15 CDI74170.1 - 6.4 5.4 26.7 0.76 8.5 17.6 2.2 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Nop14 PF04147.12 CDI74170.1 - 8.5 4.4 30.4 0.12 10.6 18.0 2.1 2 0 0 2 2 2 0 Nop14-like family Myc_N PF01056.18 CDI74170.1 - 8.7 6.1 25.6 7.3 6.4 19.2 2.1 2 0 0 2 2 2 0 Myc amino-terminal region SLC12 PF03522.15 CDI74170.1 - 8.8 5.2 25.9 1.3 8.0 15.4 2.3 2 0 0 2 2 2 0 Solute carrier family 12 SecY PF00344.20 CDI74171.1 - 1.6e-55 188.5 10.0 2e-55 188.2 10.0 1.0 1 0 0 1 1 1 1 SecY translocase QCR10 PF09796.9 CDI74171.1 - 0.56 10.3 2.7 4.8 7.3 0.1 3.2 3 1 0 3 3 3 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Sporozoite_P67 PF05642.11 CDI74172.1 - 5.1e-05 21.6 0.0 5.1e-05 21.6 0.0 8.6 4 3 1 8 8 8 2 Sporozoite P67 surface antigen RskA PF10099.9 CDI74172.1 - 0.00029 21.2 9.1 0.00029 21.2 9.1 15.0 4 2 6 10 10 10 3 Anti-sigma-K factor rskA SPRY PF00622.28 CDI74172.1 - 0.0043 17.2 0.0 0.0043 17.2 0.0 4.6 5 1 1 6 6 6 1 SPRY domain Pex14_N PF04695.13 CDI74173.1 - 0.008 16.9 13.9 0.011 16.4 13.9 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 CDI74173.1 - 0.022 14.8 16.3 0.027 14.5 16.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI74173.1 - 0.59 8.8 5.8 0.63 8.8 5.8 1.2 1 0 0 1 1 1 0 Presenilin GET2 PF08690.10 CDI74173.1 - 1.5 8.4 8.2 2.5 7.7 8.2 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 Spt20 PF12090.8 CDI74173.1 - 1.8 8.1 20.6 1.9 8.0 20.6 1.3 1 1 0 1 1 1 0 Spt20 family SR-25 PF10500.9 CDI74174.1 - 0.54 9.8 74.3 0.13 11.8 9.6 5.1 4 1 1 5 5 5 0 Nuclear RNA-splicing-associated protein Neur_chan_memb PF02932.16 CDI74174.1 - 6.6 6.7 22.2 2.4 8.2 7.4 2.8 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region TMEM51 PF15345.6 CDI74175.1 - 0.0019 18.1 1.9 0.0019 18.1 1.9 8.8 9 1 0 10 10 10 1 Transmembrane protein 51 DUF2722 PF10846.8 CDI74175.1 - 0.002 17.2 12.9 0.002 17.2 12.9 9.5 7 1 0 7 7 7 3 Protein of unknown function (DUF2722) DUF755 PF05501.11 CDI74175.1 - 0.0033 17.7 7.9 0.0033 17.7 7.9 17.1 14 3 3 17 17 17 2 Domain of unknown function (DUF755) NopRA1 PF16201.5 CDI74176.1 - 8e-07 28.8 0.6 8e-07 28.8 0.6 3.0 3 0 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 Pex16 PF08610.10 CDI74176.1 - 0.22 10.7 3.5 0.92 8.6 0.0 3.2 3 0 0 3 3 3 0 Peroxisomal membrane protein (Pex16) HHH_8 PF14716.6 CDI74177.1 - 0.079 13.3 0.1 0.71 10.3 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix domain Baculo_PEP_C PF04513.12 CDI74180.1 - 6.8 6.7 12.7 11 6.0 2.5 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Retrotrans_gag PF03732.17 CDI74181.1 - 0.099 12.9 0.2 1.1 9.6 0.0 2.3 2 0 0 2 2 2 0 Retrotransposon gag protein DUF1666 PF07891.12 CDI74181.1 - 1.4 8.5 3.4 2.5 7.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1666) FPL PF09758.9 CDI74182.1 - 1.3e-51 174.5 3.8 2.9e-51 173.4 3.8 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein BTB PF00651.31 CDI74183.1 - 3.9e-06 27.1 0.0 9.4e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Mannosyl_trans PF05007.13 CDI74184.1 - 4e-47 161.3 27.5 1.2e-28 100.7 8.8 3.5 2 1 1 3 3 3 2 Mannosyltransferase (PIG-M) PIG-U PF06728.13 CDI74184.1 - 3.1e-15 56.1 0.1 1.6e-14 53.8 0.0 2.0 1 1 1 2 2 2 1 GPI transamidase subunit PIG-U GT87 PF09594.10 CDI74184.1 - 0.00043 20.1 5.1 0.00043 20.1 5.1 3.7 2 1 1 3 3 3 1 Glycosyltransferase family 87 Androgen_recep PF02166.16 CDI74184.1 - 0.016 14.1 0.3 0.022 13.6 0.3 1.1 1 0 0 1 1 1 0 Androgen receptor DUF4094 PF13334.6 CDI74184.1 - 5.5 7.5 5.8 0.41 11.1 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) Myosin_head PF00063.21 CDI74185.1 - 3.7e-30 104.8 0.0 1.4e-21 76.5 0.0 3.1 2 1 0 2 2 2 2 Myosin head (motor domain) RCC1 PF00415.18 CDI74185.1 - 5e-26 91.1 11.0 7.9e-09 36.0 0.1 5.7 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDI74185.1 - 4.7e-09 35.8 0.4 4.7e-09 35.8 0.4 5.5 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat IQ PF00612.27 CDI74185.1 - 2.1e-06 27.0 32.2 0.00012 21.6 1.5 6.1 6 0 0 6 6 6 3 IQ calmodulin-binding motif Kin17_mid PF10357.9 CDI74187.1 - 4.7e-43 146.1 2.6 4.7e-43 146.1 2.6 1.8 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein KN17_SH3 PF18131.1 CDI74187.1 - 1.4e-18 66.7 0.9 2.5e-18 65.9 0.9 1.5 1 0 0 1 1 1 1 KN17 SH3-like C-terminal domain zf-met PF12874.7 CDI74187.1 - 0.0073 16.7 4.0 0.018 15.4 4.0 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type NdhS PF11623.8 CDI74187.1 - 0.0078 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H dehydrogenase subunit S zf-C2H2_jaz PF12171.8 CDI74187.1 - 0.35 11.2 7.3 0.13 12.6 4.2 2.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF4148 PF13663.6 CDI74188.1 - 0.0038 17.4 3.5 0.0038 17.4 3.5 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF4148) DUF4525 PF15027.6 CDI74189.1 - 0.072 12.8 4.1 0.13 12.0 1.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4525) NAD_binding_9 PF13454.6 CDI74190.1 - 0.23 11.4 2.2 0.39 10.7 2.0 1.5 1 1 0 1 1 1 0 FAD-NAD(P)-binding AAA_6 PF12774.7 CDI74192.1 - 1.8e-120 401.9 2.2 3.8e-119 397.5 0.0 3.2 2 1 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDI74192.1 - 2.7e-82 277.0 2.3 2.7e-82 277.0 2.3 3.0 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 MT PF12777.7 CDI74192.1 - 1.7e-55 188.4 4.2 3.7e-55 187.3 4.2 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.7 CDI74192.1 - 7.8e-50 169.0 0.0 7.8e-50 169.0 0.0 3.0 4 0 0 4 4 3 1 ATP-binding dynein motor region AAA_8 PF12780.7 CDI74192.1 - 1e-34 120.1 0.1 3.9e-27 95.2 0.0 3.3 3 0 0 3 3 3 2 P-loop containing dynein motor region D4 Dynein_heavy PF03028.15 CDI74192.1 - 1.6e-34 118.6 0.0 6.5e-33 113.4 0.0 3.5 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain AAA_7 PF12775.7 CDI74192.1 - 1.8e-28 99.3 0.0 2.9e-15 56.3 0.0 4.7 4 0 0 4 4 4 3 P-loop containing dynein motor region AAA_lid_11 PF18198.1 CDI74192.1 - 4.4e-17 62.4 0.0 1.5e-16 60.6 0.0 2.0 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_AAA_lid PF17852.1 CDI74192.1 - 1.1e-16 61.1 0.2 5.4e-16 58.8 0.0 2.4 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 CDI74192.1 - 1.7e-07 31.3 3.3 0.22 11.5 0.0 5.7 5 1 0 5 5 5 2 AAA domain (dynein-related subfamily) Dynein_C PF18199.1 CDI74192.1 - 5.7e-07 29.0 0.4 5.7e-07 29.0 0.4 2.8 4 0 0 4 4 4 1 Dynein heavy chain C-terminal domain DUF4407 PF14362.6 CDI74192.1 - 0.00012 21.6 5.6 0.00012 21.6 5.6 3.5 4 0 0 4 4 2 1 Domain of unknown function (DUF4407) AAA PF00004.29 CDI74192.1 - 0.00029 21.3 0.6 0.32 11.4 0.0 4.3 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDI74192.1 - 0.0012 19.2 2.5 25 5.1 0.0 5.3 4 0 0 4 4 4 0 AAA domain Mg_chelatase PF01078.21 CDI74192.1 - 0.023 14.1 4.1 2.5 7.4 0.2 3.5 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_lid_1 PF17857.1 CDI74192.1 - 0.024 14.9 0.0 0.076 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA+ lid domain RNA_helicase PF00910.22 CDI74192.1 - 0.035 14.5 0.2 20 5.6 0.0 3.4 3 0 0 3 3 3 0 RNA helicase DUF812 PF05667.11 CDI74192.1 - 0.11 11.3 17.0 0.23 10.3 8.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF812) MPS2 PF17060.5 CDI74192.1 - 0.18 11.0 0.8 0.49 9.6 0.8 1.7 1 0 0 1 1 1 0 Monopolar spindle protein 2 Synaptonemal_3 PF15191.6 CDI74192.1 - 1.6 8.6 4.9 15 5.4 3.3 2.7 2 0 0 2 2 2 0 Synaptonemal complex central element protein 3 V_ATPase_I PF01496.19 CDI74192.1 - 6.9 4.4 9.6 8.3 4.2 3.2 2.5 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family HD_2 PF12917.7 CDI74193.1 - 0.13 12.0 3.0 0.36 10.6 3.0 1.7 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme DUF2722 PF10846.8 CDI74194.1 - 3.8e-05 22.8 10.1 4.7e-05 22.5 10.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) ABC2_membrane_2 PF12679.7 CDI74194.1 - 0.14 11.4 0.7 0.17 11.2 0.7 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein Presenilin PF01080.17 CDI74194.1 - 0.16 10.7 7.4 0.2 10.4 7.4 1.2 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 CDI74194.1 - 0.42 10.3 2.6 1.4 8.6 2.4 1.7 2 0 0 2 2 2 0 Connexin Glt_symporter PF03616.14 CDI74194.1 - 0.66 8.6 1.4 0.88 8.2 1.4 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter Peptidase_S49_N PF08496.10 CDI74194.1 - 0.87 9.6 7.6 0.22 11.6 4.5 1.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF3464 PF11947.8 CDI74194.1 - 1.2 8.9 8.8 0.52 10.1 4.5 2.0 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DUF775 PF05603.12 CDI74194.1 - 3.1 7.3 10.3 0.14 11.7 4.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF775) Suf PF05843.14 CDI74194.1 - 5.4 6.9 19.8 1.5 8.7 16.8 1.5 1 1 1 2 2 2 0 Suppressor of forked protein (Suf) Ndc1_Nup PF09531.10 CDI74194.1 - 6.2 5.4 13.2 7.1 5.2 13.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 CDI74194.1 - 7.1 4.8 19.4 7.6 4.7 19.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ribosomal_60s PF00428.19 CDI74194.1 - 7.8 7.2 29.3 1.3 9.6 22.1 2.5 2 1 0 2 2 2 0 60s Acidic ribosomal protein EIIBC-GUT_N PF03612.14 CDI74194.1 - 9.8 5.9 10.8 3.1 7.5 6.2 1.9 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus TRAUB PF08164.12 CDI74195.1 - 5.4e-13 49.3 0.0 5.4e-13 49.3 0.0 3.6 3 1 0 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 CDI74195.1 - 0.00077 20.2 9.2 0.00077 20.2 9.2 2.5 1 1 1 2 2 2 1 Apoptosis antagonizing transcription factor O-antigen_lig PF13425.6 CDI74195.1 - 5.4 5.7 8.6 7.1 5.3 8.6 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SprA-related PF12118.8 CDI74199.1 - 0.00044 19.5 18.7 0.00051 19.3 18.7 1.0 1 0 0 1 1 1 1 SprA-related family Myc_N PF01056.18 CDI74199.1 - 0.0017 18.3 7.6 0.0019 18.2 7.6 1.1 1 0 0 1 1 1 1 Myc amino-terminal region NTP_transf_8 PF12281.8 CDI74199.1 - 0.0031 17.5 3.0 0.0038 17.3 3.0 1.1 1 0 0 1 1 1 1 Nucleotidyltransferase CDK5_activator PF03261.15 CDI74199.1 - 0.0079 15.8 3.4 0.0087 15.6 3.4 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase 5 activator protein Ribosomal_60s PF00428.19 CDI74199.1 - 0.022 15.4 12.0 0.18 12.4 4.9 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein PBP_sp32 PF07222.12 CDI74199.1 - 0.035 13.6 12.4 0.041 13.3 12.4 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 TFIIA PF03153.13 CDI74199.1 - 0.067 13.2 23.5 0.072 13.1 23.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI74199.1 - 0.33 10.5 31.3 0.42 10.2 31.3 1.1 1 0 0 1 1 1 0 Spt20 family Serinc PF03348.15 CDI74199.1 - 0.57 9.1 3.9 0.59 9.0 3.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) eIF-3_zeta PF05091.12 CDI74199.1 - 0.57 9.1 16.3 0.62 9.0 16.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4175 PF13779.6 CDI74199.1 - 0.69 7.7 31.3 0.79 7.6 31.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) RR_TM4-6 PF06459.12 CDI74199.1 - 0.99 9.2 12.5 1.1 9.0 12.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 CDI74199.1 - 1.2 9.3 11.5 1.3 9.1 11.5 1.2 1 0 0 1 1 1 0 DDHD domain Nop25 PF09805.9 CDI74199.1 - 1.5 9.3 20.4 1.9 8.9 20.4 1.0 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Neur_chan_memb PF02932.16 CDI74199.1 - 1.6 8.7 7.4 1.8 8.5 7.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.10 CDI74199.1 - 1.7 7.2 11.7 2.2 6.9 11.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAM60A PF15396.6 CDI74199.1 - 1.8 8.5 9.2 2.1 8.3 9.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A ALMT PF11744.8 CDI74199.1 - 2.2 7.0 8.2 2.3 7.0 8.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Suf PF05843.14 CDI74199.1 - 3 7.7 16.5 3.5 7.5 16.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RXLR PF16810.5 CDI74199.1 - 3.3 8.2 9.9 5.8 7.3 9.9 1.5 1 1 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity SpoIIP PF07454.11 CDI74199.1 - 3.4 7.0 14.1 4.2 6.8 14.1 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TERB2 PF15101.6 CDI74199.1 - 3.9 7.5 16.2 4.6 7.2 16.2 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF5524 PF17662.1 CDI74199.1 - 4 6.7 11.4 4.5 6.5 11.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5524) V_ATPase_I PF01496.19 CDI74199.1 - 5.4 4.8 13.3 6.1 4.6 13.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Band_3_cyto PF07565.13 CDI74199.1 - 8.1 6.2 11.8 9.6 5.9 11.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Connexin PF00029.19 CDI74199.1 - 8.1 6.1 8.7 10 5.8 8.7 1.3 1 0 0 1 1 1 0 Connexin DUF4746 PF15928.5 CDI74199.1 - 8.9 5.6 13.9 11 5.3 13.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Shadoo PF14999.6 CDI74200.1 - 0.0016 18.6 0.3 0.0026 17.9 0.3 1.3 1 0 0 1 1 1 1 Shadow of prion protein, neuroprotective Activator_LAG-3 PF11498.8 CDI74200.1 - 0.0023 17.0 27.9 0.0023 17.0 27.9 4.2 2 1 0 2 2 2 1 Transcriptional activator LAG-3 RskA PF10099.9 CDI74201.1 - 0.069 13.4 0.0 0.069 13.4 0.0 10.3 3 2 4 7 7 7 0 Anti-sigma-K factor rskA Cohesin_HEAT PF12765.7 CDI74201.1 - 0.66 10.3 4.0 22 5.5 0.1 2.9 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion DnaJ_C PF01556.18 CDI74202.1 - 7.3e-16 58.6 0.1 1.2e-15 57.8 0.1 1.4 2 0 0 2 2 2 1 DnaJ C terminal domain DUF2722 PF10846.8 CDI74203.1 - 0.00011 21.3 6.1 0.00014 21.0 6.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI74203.1 - 0.00062 19.4 13.4 0.0014 18.2 13.4 1.6 1 0 0 1 1 1 1 Spt20 family DUF4834 PF16118.5 CDI74203.1 - 0.00086 20.2 0.0 0.00086 20.2 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) Pex24p PF06398.11 CDI74203.1 - 0.061 12.3 1.9 0.086 11.8 1.9 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin TMEM51 PF15345.6 CDI74203.1 - 0.63 9.8 5.7 1.2 8.9 5.7 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 Suf PF05843.14 CDI74203.1 - 2.5 8.0 10.2 4.7 7.1 10.2 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Roughex PF06020.11 CDI74203.1 - 3.3 6.7 4.5 4.3 6.3 4.5 1.2 1 0 0 1 1 1 0 Drosophila roughex protein CAP_N PF01213.19 CDI74203.1 - 3.3 7.1 20.9 0.66 9.4 14.8 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Thioredoxin PF00085.20 CDI74204.1 - 3.8e-07 30.0 0.0 5.9e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 CDI74204.1 - 0.012 15.5 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain DUF4904 PF16247.5 CDI74204.1 - 0.058 13.2 0.0 0.096 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4904) Amidohydro_1 PF01979.20 CDI74205.1 - 0.65 9.2 9.0 0.88 8.8 9.0 1.1 1 0 0 1 1 1 0 Amidohydrolase family Presenilin PF01080.17 CDI74205.1 - 1.1 7.9 15.5 0.019 13.7 0.6 2.0 1 1 1 2 2 2 0 Presenilin PAT1 PF09770.9 CDI74205.1 - 2.4 6.3 10.6 2.7 6.1 10.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RskA PF10099.9 CDI74206.1 - 4.9e-06 26.9 4.4 4.9e-06 26.9 4.4 4.4 2 2 1 3 3 3 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI74206.1 - 0.014 15.1 14.9 0.014 15.1 14.9 5.1 3 1 2 5 5 5 0 Spt20 family Rpp20 PF12328.8 CDI74206.1 - 0.18 11.8 0.1 0.18 11.8 0.1 4.7 3 1 1 4 4 4 0 Rpp20 subunit of nuclear RNase MRP and P Caldesmon PF02029.15 CDI74206.1 - 4.3 6.0 72.2 1.3 7.7 22.1 2.1 2 0 0 2 2 2 0 Caldesmon 14-3-3 PF00244.20 CDI74208.1 - 1.1e-98 329.2 7.3 1.3e-98 329.0 7.3 1.0 1 0 0 1 1 1 1 14-3-3 protein Peptidase_C98 PF15499.6 CDI74208.1 - 0.034 13.6 0.0 0.066 12.7 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase MKT1_N PF12247.8 CDI74208.1 - 0.2 12.1 1.1 0.51 10.7 0.1 2.3 2 1 0 2 2 2 0 Temperature dependent protein affecting M2 dsRNA replication EGF_CA PF07645.15 CDI74209.1 - 3.5e-26 91.1 70.4 1e-10 41.6 7.6 5.3 5 0 0 5 5 5 5 Calcium-binding EGF domain EGF_3 PF12947.7 CDI74209.1 - 2.9e-13 49.8 63.6 2.7e-06 27.4 9.7 6.1 5 1 1 6 6 6 5 EGF domain cEGF PF12662.7 CDI74209.1 - 3.4e-11 42.8 35.4 1.1e-05 25.2 0.8 6.4 6 0 0 6 6 6 4 Complement Clr-like EGF-like EGF PF00008.27 CDI74209.1 - 3.7e-05 23.9 58.0 0.00063 20.0 7.7 6.5 6 1 1 7 7 7 4 EGF-like domain EGF_MSP1_1 PF12946.7 CDI74209.1 - 0.0012 18.8 6.7 0.0012 18.8 6.7 4.7 3 1 0 4 4 4 2 MSP1 EGF domain 1 hEGF PF12661.7 CDI74209.1 - 0.0037 17.8 5.5 0.0037 17.8 5.5 7.6 7 2 0 7 7 7 1 Human growth factor-like EGF FXa_inhibition PF14670.6 CDI74209.1 - 0.012 15.9 8.3 0.012 15.9 8.3 6.1 6 0 0 6 6 6 0 Coagulation Factor Xa inhibitory site ORC3_N PF07034.11 CDI74210.1 - 5.4e-09 35.6 0.2 5.4e-09 35.6 0.2 6.2 6 1 0 6 6 6 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 CDI74210.1 - 0.0027 17.8 6.0 0.0027 17.8 6.0 8.1 6 2 1 7 7 7 1 Origin recognition complex winged helix C-terminal Spt20 PF12090.8 CDI74210.1 - 0.019 14.6 0.5 0.019 14.6 0.5 8.8 9 1 0 9 9 9 0 Spt20 family RLL PF10036.9 CDI74210.1 - 0.027 14.3 0.1 0.027 14.3 0.1 7.1 6 2 0 6 6 6 0 RNA transcription, translation and transport factor protein DIE2_ALG10 PF04922.12 CDI74210.1 - 7.6 5.7 11.9 0.79 8.9 5.8 2.4 2 0 0 2 2 2 0 DIE2/ALG10 family DUF726 PF05277.12 CDI74211.1 - 0.57 9.1 7.9 0.75 8.7 5.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF726) R_equi_Vir PF05526.11 CDI74213.1 - 0.052 13.4 4.7 0.067 13.1 4.7 1.2 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein CT47 PF15623.6 CDI74213.1 - 0.087 12.7 15.1 0.11 12.4 15.1 1.1 1 0 0 1 1 1 0 Cancer/testis gene family 47 TFIIA PF03153.13 CDI74213.1 - 0.096 12.7 15.3 0.11 12.5 15.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI74213.1 - 0.53 9.0 2.6 0.59 8.8 2.6 1.0 1 0 0 1 1 1 0 Presenilin DUF5529 PF17669.1 CDI74213.1 - 4.7 7.2 6.6 0.56 10.2 1.8 1.6 1 1 1 2 2 2 0 Family of unknown function (DUF5529) Spt20 PF12090.8 CDI74213.1 - 9.8 5.7 17.5 13 5.3 17.5 1.1 1 0 0 1 1 1 0 Spt20 family SR-25 PF10500.9 CDI74216.1 - 0.0047 16.6 19.0 0.0047 16.6 19.0 3.9 2 2 1 3 3 3 1 Nuclear RNA-splicing-associated protein SDA1 PF05285.12 CDI74216.1 - 9.9 5.5 60.6 1.1 8.6 21.4 2.1 2 0 0 2 2 2 0 SDA1 DUF737 PF05300.11 CDI74217.1 - 0.00089 19.7 29.5 0.00089 19.7 29.5 6.4 3 2 1 5 5 5 1 Protein of unknown function (DUF737) SMRP1 PF15181.6 CDI74217.1 - 0.066 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Spermatid-specific manchette-related protein 1 DUF4179 PF13786.6 CDI74218.1 - 0.84 10.1 6.5 3.3 8.2 5.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) HpaB_N PF11794.8 CDI74219.1 - 0.07 12.8 1.2 0.12 12.0 1.2 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal DUF732 PF05305.14 CDI74219.1 - 0.087 13.2 16.8 0.096 13.1 14.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF732) VIT1 PF01988.19 CDI74219.1 - 0.34 10.7 8.6 0.046 13.6 4.6 1.5 1 1 1 2 2 2 0 VIT family Ribosomal_60s PF00428.19 CDI74219.1 - 0.54 10.9 15.2 0.088 13.4 10.4 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein PC_rep PF01851.22 CDI74220.1 - 0.0066 16.8 0.5 0.046 14.2 0.1 2.7 2 0 0 2 2 2 1 Proteasome/cyclosome repeat SPT16 PF08644.11 CDI74220.1 - 0.25 11.5 8.2 0.024 14.8 2.3 2.1 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) TFIIA PF03153.13 CDI74220.1 - 0.88 9.5 73.0 3.1 7.7 21.1 3.1 1 1 2 3 3 3 0 Transcription factor IIA, alpha/beta subunit Pro_isomerase PF00160.21 CDI74221.1 - 1.4e-11 44.9 0.0 7.3e-07 29.6 0.0 2.0 1 1 1 2 2 2 2 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Spt20 PF12090.8 CDI74222.1 - 2.3 7.8 10.5 3.2 7.3 10.5 1.2 1 0 0 1 1 1 0 Spt20 family Bromodomain PF00439.25 CDI74223.1 - 1.7e-17 63.3 0.1 2.6e-17 62.6 0.1 1.3 1 0 0 1 1 1 1 Bromodomain 3HBOH PF10605.9 CDI74223.1 - 0.0011 17.3 1.5 0.0016 16.8 1.5 1.1 1 0 0 1 1 1 1 3HB-oligomer hydrolase (3HBOH) DUF1697 PF08002.11 CDI74223.1 - 0.024 15.1 1.7 0.051 14.0 0.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1697) DUF3583 PF12126.8 CDI74223.1 - 0.056 12.9 0.3 0.11 12.0 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) DUF2195 PF09961.9 CDI74223.1 - 0.097 12.6 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2195) MAP17 PF15807.5 CDI74226.1 - 8e-05 22.9 1.8 8e-05 22.9 1.8 3.1 2 1 0 2 2 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 OATP PF03137.20 CDI74226.1 - 0.0017 16.8 2.2 0.0017 16.8 2.2 2.6 2 1 0 2 2 1 1 Organic Anion Transporter Polypeptide (OATP) family NicO PF03824.16 CDI74226.1 - 0.0024 17.2 0.4 0.0024 17.2 0.4 2.4 2 1 0 2 2 1 1 High-affinity nickel-transport protein V_ATPase_I PF01496.19 CDI74226.1 - 0.0027 15.7 11.3 0.0027 15.7 11.3 2.1 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family SR-25 PF10500.9 CDI74226.1 - 0.0058 16.3 14.3 0.0058 16.3 14.3 2.7 2 1 1 3 3 3 2 Nuclear RNA-splicing-associated protein CcmD PF04995.14 CDI74226.1 - 0.0077 16.3 5.0 0.0077 16.3 5.0 4.6 4 1 0 4 4 2 1 Heme exporter protein D (CcmD) LapA_dom PF06305.11 CDI74226.1 - 0.016 15.0 3.4 0.016 15.0 3.4 4.2 4 0 0 4 4 2 0 Lipopolysaccharide assembly protein A domain Baculo_11_kDa PF06143.11 CDI74226.1 - 0.019 14.5 0.3 0.019 14.5 0.3 4.4 4 2 0 4 4 2 0 Baculovirus 11 kDa family Conotoxin PF02950.17 CDI74226.1 - 0.02 15.9 2.8 0.02 15.9 2.8 4.2 2 2 2 4 4 4 0 Conotoxin OPA3 PF07047.12 CDI74226.1 - 0.081 12.7 0.2 0.081 12.7 0.2 4.1 4 0 0 4 4 4 0 Optic atrophy 3 protein (OPA3) L_HMGIC_fpl PF10242.9 CDI74226.1 - 0.11 12.7 0.3 0.26 11.5 0.3 1.7 1 0 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein CCDC106 PF15794.5 CDI74226.1 - 0.14 11.9 48.0 0.25 11.0 20.6 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 7TM_GPCR_Srv PF10323.9 CDI74226.1 - 0.2 11.0 0.1 0.2 11.0 0.1 3.6 4 0 0 4 4 3 0 Serpentine type 7TM GPCR chemoreceptor Srv TRAP_alpha PF03896.16 CDI74226.1 - 0.28 10.3 24.0 0.021 14.1 3.4 2.5 2 1 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF2052 PF09747.9 CDI74226.1 - 1.8 8.6 40.2 1.7 8.7 14.4 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Peptidase_S64 PF08192.11 CDI74226.1 - 2.2 6.7 50.6 0.2 10.1 21.7 2.0 2 0 0 2 2 2 0 Peptidase family S64 Suf PF05843.14 CDI74226.1 - 2.6 7.9 57.6 0.27 11.2 23.5 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) SLC12 PF03522.15 CDI74226.1 - 5.2 6.0 49.1 0.22 10.5 14.6 2.0 2 0 0 2 2 2 0 Solute carrier family 12 ASD2 PF08687.11 CDI74226.1 - 9.6 5.7 53.3 1.1 8.7 19.1 2.1 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 UPF0564 PF10595.9 CDI74227.1 - 1.3e-05 24.4 11.0 1.3e-05 24.4 11.0 5.2 5 0 0 5 5 5 1 Uncharacterised protein family UPF0564 Spt20 PF12090.8 CDI74227.1 - 2.2e-05 24.2 2.4 2.2e-05 24.2 2.4 7.4 6 2 1 7 7 7 3 Spt20 family RskA PF10099.9 CDI74227.1 - 0.0018 18.6 0.0 0.0018 18.6 0.0 10.7 1 1 3 5 5 5 1 Anti-sigma-K factor rskA UPF0258 PF06789.12 CDI74227.1 - 0.14 12.3 0.1 0.14 12.3 0.1 3.4 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0258) SR-25 PF10500.9 CDI74228.1 - 7.6e-05 22.4 9.6 7.6e-05 22.4 9.6 5.8 5 1 0 5 5 5 3 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI74228.1 - 0.0028 16.7 7.6 0.0028 16.7 7.6 8.0 6 3 0 7 7 7 1 Protein of unknown function (DUF2722) AXIN1_TNKS_BD PF16646.5 CDI74228.1 - 0.16 12.9 0.1 0.16 12.9 0.1 7.4 7 0 0 7 7 7 0 Axin-1 tankyrase binding domain CAF1 PF04857.20 CDI74228.1 - 1.5 7.9 0.0 1.5 7.9 0.0 3.9 3 3 0 3 3 3 0 CAF1 family ribonuclease IMUP PF15761.5 CDI74228.1 - 3.4 8.4 50.9 1.1 10.0 4.6 4.8 3 1 0 3 3 3 0 Immortalisation up-regulated protein HA2 PF04408.23 CDI74229.1 - 2.5e-10 40.6 0.0 2.5e-10 40.6 0.0 5.7 4 2 0 4 4 4 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CDI74229.1 - 6.4e-10 39.4 1.8 3.3e-09 37.0 0.0 3.1 4 0 0 4 4 4 1 Helicase conserved C-terminal domain TPP_enzyme_N PF02776.18 CDI74229.1 - 0.0053 16.4 1.1 0.0053 16.4 1.1 3.4 4 1 0 4 4 4 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PAT1 PF09770.9 CDI74230.1 - 0.014 13.8 32.6 0.016 13.5 32.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Exonuc_VII_L PF02601.15 CDI74230.1 - 0.28 10.7 27.6 0.5 9.9 27.4 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Hamartin PF04388.12 CDI74230.1 - 0.88 8.2 24.4 1.3 7.6 24.4 1.3 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 CDI74230.1 - 9.7 3.1 26.8 14 2.7 26.8 1.4 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Otopetrin PF03189.13 CDI74231.1 - 2.3e-08 33.3 0.0 2.3e-08 33.3 0.0 5.9 4 3 0 4 4 4 1 Otopetrin Spt20 PF12090.8 CDI74231.1 - 0.001 18.7 13.7 0.001 18.7 13.7 12.2 7 4 1 9 9 9 1 Spt20 family DUF2722 PF10846.8 CDI74231.1 - 0.0022 17.0 4.3 0.0022 17.0 4.3 12.3 6 2 2 9 9 9 1 Protein of unknown function (DUF2722) DUF826 PF05696.11 CDI74231.1 - 5.4 7.2 6.9 1.8 8.7 0.7 3.8 2 0 0 2 2 2 0 Protein of unknown function (DUF826) RabGAP-TBC PF00566.18 CDI74232.1 - 1.1e-06 28.5 0.8 1.6e-06 27.9 0.1 1.6 1 1 1 2 2 2 1 Rab-GTPase-TBC domain Apt1 PF10351.9 CDI74232.1 - 0.0018 17.2 31.5 0.0031 16.4 31.5 1.3 1 0 0 1 1 1 1 Golgi-body localisation protein domain DUF572 PF04502.13 CDI74232.1 - 0.13 11.9 17.3 0.019 14.6 13.1 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF572) SLC12 PF03522.15 CDI74232.1 - 0.21 10.6 5.5 0.3 10.0 5.5 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Zip PF02535.22 CDI74232.1 - 0.3 10.3 9.2 0.49 9.6 9.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 CDI74232.1 - 0.55 8.9 16.4 1.1 8.0 16.4 1.4 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI74232.1 - 0.77 9.5 9.3 0.81 9.5 4.3 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 CDI74232.1 - 2.7 6.0 17.9 4.2 5.4 17.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PPP4R2 PF09184.11 CDI74232.1 - 3.9 7.0 17.8 6.9 6.2 17.8 1.4 1 0 0 1 1 1 0 PPP4R2 PNISR PF15996.5 CDI74232.1 - 7 6.9 12.9 0.66 10.2 7.4 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Band_3_cyto PF07565.13 CDI74232.1 - 7.2 6.3 8.7 13 5.5 8.7 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Spt20 PF12090.8 CDI74233.1 - 0.0017 18.0 7.4 0.0017 18.0 7.4 4.2 4 0 0 4 4 4 3 Spt20 family V_ATPase_I PF01496.19 CDI74233.1 - 4.3 5.1 9.9 6.8 4.5 9.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2407 PF10302.9 CDI74233.1 - 7 7.3 10.6 5.2 7.7 7.4 2.4 2 1 0 2 2 2 0 DUF2407 ubiquitin-like domain Importin_rep_2 PF18786.1 CDI74234.1 - 0.029 14.2 0.0 10 6.1 0.0 2.3 2 0 0 2 2 2 0 Importin 13 repeat Herpes_gI PF01688.17 CDI74234.1 - 0.15 12.0 0.1 15 5.5 0.0 2.0 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein I Zip PF02535.22 CDI74235.1 - 0.0011 18.3 3.8 0.0013 18.0 3.8 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Otopetrin PF03189.13 CDI74235.1 - 0.0019 17.1 3.1 0.002 17.0 3.1 1.1 1 0 0 1 1 1 1 Otopetrin SAPS PF04499.15 CDI74235.1 - 0.0023 16.8 8.7 0.0028 16.5 8.7 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein TFIIA PF03153.13 CDI74235.1 - 0.0083 16.2 42.8 0.014 15.4 42.8 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Raftlin PF15250.6 CDI74235.1 - 0.012 14.4 12.3 0.016 14.0 12.3 1.1 1 0 0 1 1 1 0 Raftlin Tim54 PF11711.8 CDI74235.1 - 0.014 14.2 14.7 0.025 13.4 14.7 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 CDI74235.1 - 0.015 15.1 22.9 0.021 14.7 22.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NPR3 PF03666.13 CDI74235.1 - 0.025 13.4 22.6 0.043 12.6 22.6 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 CDI74235.1 - 0.025 13.3 27.3 0.034 12.9 27.3 1.1 1 0 0 1 1 1 0 Presenilin DUF3807 PF12720.7 CDI74235.1 - 0.047 14.0 29.4 0.075 13.3 29.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF4045 PF13254.6 CDI74235.1 - 0.06 13.0 18.0 0.087 12.5 18.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Band_3_cyto PF07565.13 CDI74235.1 - 0.06 13.1 13.8 0.11 12.3 13.8 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PA26 PF04636.13 CDI74235.1 - 0.085 11.8 11.7 0.11 11.4 11.7 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Ndc1_Nup PF09531.10 CDI74235.1 - 0.12 11.0 13.4 0.16 10.6 13.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAM60A PF15396.6 CDI74235.1 - 0.12 12.3 19.5 0.18 11.8 19.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF913 PF06025.12 CDI74235.1 - 0.14 11.1 11.9 0.2 10.6 11.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2370 PF10176.9 CDI74235.1 - 0.17 11.5 9.0 0.26 10.9 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) CLN3 PF02487.17 CDI74235.1 - 0.17 10.9 13.1 0.25 10.3 13.1 1.2 1 0 0 1 1 1 0 CLN3 protein Mem_trans PF03547.18 CDI74235.1 - 0.17 10.2 1.5 0.19 10.1 1.5 1.1 1 0 0 1 1 1 0 Membrane transport protein SARAF PF06682.12 CDI74235.1 - 0.2 11.3 19.3 0.27 10.8 19.3 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis eIF-3_zeta PF05091.12 CDI74235.1 - 0.21 10.6 27.0 0.29 10.1 27.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) LAP1C PF05609.12 CDI74235.1 - 0.26 10.4 20.1 0.34 10.0 20.1 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Pox_Ag35 PF03286.14 CDI74235.1 - 0.39 10.5 14.2 0.65 9.8 14.2 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein V_ATPase_I PF01496.19 CDI74235.1 - 0.41 8.5 23.7 0.61 7.9 23.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Smg8_Smg9 PF10220.9 CDI74235.1 - 0.44 8.8 18.4 0.57 8.4 18.4 1.0 1 0 0 1 1 1 0 Smg8_Smg9 DUF5352 PF17303.2 CDI74235.1 - 0.45 10.3 5.9 0.86 9.4 5.9 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5352) PAT1 PF09770.9 CDI74235.1 - 0.46 8.7 36.4 0.63 8.2 36.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 CDI74235.1 - 0.53 10.3 19.1 0.86 9.6 19.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 CDI74235.1 - 0.7 8.1 22.7 0.92 7.7 22.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI74235.1 - 1.1 8.3 25.1 1.5 7.8 25.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PPL5 PF18168.1 CDI74235.1 - 1.2 8.4 12.8 2.3 7.4 12.8 1.4 1 0 0 1 1 1 0 Prim-pol family 5 DUF2052 PF09747.9 CDI74235.1 - 1.3 9.1 27.3 0.49 10.5 24.8 1.5 2 0 0 2 2 1 0 Coiled-coil domain containing protein (DUF2052) GREB1 PF15782.5 CDI74235.1 - 1.4 6.0 21.1 1.7 5.7 21.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AAA_11 PF13086.6 CDI74235.1 - 1.4 8.7 21.3 2.1 8.0 21.3 1.2 1 0 0 1 1 1 0 AAA domain DUF5427 PF10310.9 CDI74235.1 - 1.6 7.6 29.3 2.3 7.1 29.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF2828 PF11443.8 CDI74235.1 - 1.6 6.7 20.9 2.2 6.2 20.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Lin-8 PF03353.15 CDI74235.1 - 2 7.9 29.5 3 7.3 29.5 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Endostatin PF06482.11 CDI74235.1 - 2.1 7.8 21.3 3.1 7.2 21.3 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin GPCR_chapero_1 PF11904.8 CDI74235.1 - 2.1 7.7 15.5 3.1 7.2 15.5 1.2 1 0 0 1 1 1 0 GPCR-chaperone DUF2151 PF10221.9 CDI74235.1 - 2.3 6.7 13.8 3.2 6.2 13.8 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Paramyxo_ncap PF00973.19 CDI74235.1 - 2.5 6.9 17.2 3.4 6.5 17.2 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Pex14_N PF04695.13 CDI74235.1 - 2.7 8.7 36.2 5.5 7.6 36.2 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HemX PF04375.14 CDI74235.1 - 2.7 7.2 38.1 4.1 6.6 38.1 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Sin_N PF04801.13 CDI74235.1 - 3.1 6.9 34.2 5.5 6.1 34.2 1.4 1 0 0 1 1 1 0 Sin-like protein conserved region Hamartin PF04388.12 CDI74235.1 - 3.4 6.2 20.9 4.5 5.8 20.9 1.1 1 0 0 1 1 1 0 Hamartin protein Hid1 PF12722.7 CDI74235.1 - 3.8 5.5 23.4 5.2 5.1 23.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FliP PF00813.20 CDI74235.1 - 3.9 7.3 5.3 6.4 6.6 5.3 1.4 1 0 0 1 1 1 0 FliP family MCM_bind PF09739.9 CDI74235.1 - 4.5 5.6 23.5 6.3 5.1 23.5 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Nop53 PF07767.11 CDI74235.1 - 5.7 6.2 35.3 8.9 5.6 35.3 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) FapA PF03961.13 CDI74235.1 - 6 5.3 14.7 8.4 4.9 14.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A MDM10 PF12519.8 CDI74235.1 - 6.2 5.6 21.7 8.5 5.1 21.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 BORG_CEP PF14957.6 CDI74235.1 - 6.6 7.9 19.3 10 7.3 17.4 2.0 2 0 0 2 2 2 0 Cdc42 effector Spore_coat_CotO PF14153.6 CDI74235.1 - 8.5 6.3 38.0 14 5.5 38.0 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Mucin PF01456.17 CDI74236.1 - 0.0012 18.9 3.7 0.0012 18.9 3.7 2.2 1 1 0 2 2 2 1 Mucin-like glycoprotein SR-25 PF10500.9 CDI74236.1 - 0.003 17.2 11.1 0.003 17.2 11.1 3.1 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein DUF979 PF06166.12 CDI74236.1 - 0.018 14.2 1.4 0.024 13.8 0.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF979) Dehydrin PF00257.19 CDI74236.1 - 0.022 15.3 9.9 0.022 15.3 9.9 3.1 3 0 0 3 3 3 0 Dehydrin PA26 PF04636.13 CDI74236.1 - 0.027 13.4 7.9 0.037 12.9 7.9 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) EphA2_TM PF14575.6 CDI74236.1 - 0.051 14.5 0.5 0.051 14.5 0.5 2.6 2 1 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain EIF4E-T PF10477.9 CDI74236.1 - 0.11 11.3 27.6 0.15 10.8 27.6 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF4834 PF16118.5 CDI74236.1 - 0.15 13.0 12.9 0.44 11.5 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TERB2 PF15101.6 CDI74236.1 - 0.22 11.6 21.0 0.16 12.0 9.3 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Endomucin PF07010.12 CDI74236.1 - 0.23 11.4 25.3 0.33 10.9 25.3 1.3 1 0 0 1 1 1 0 Endomucin GREB1 PF15782.5 CDI74236.1 - 0.37 7.9 22.7 0.42 7.7 22.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF45 PF01863.17 CDI74236.1 - 0.51 10.4 8.7 0.096 12.7 2.3 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF45 Afi1 PF07792.12 CDI74236.1 - 0.53 10.8 10.8 4.6 7.7 0.1 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2232 PF09991.9 CDI74236.1 - 0.63 9.2 12.1 0.8 8.8 3.9 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) GRP PF07172.11 CDI74236.1 - 0.77 10.5 0.1 0.77 10.5 0.1 2.5 1 1 0 2 2 2 0 Glycine rich protein family MPM1 PF17234.2 CDI74236.1 - 1 9.6 16.8 3 8.1 7.8 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF4770 PF15994.5 CDI74236.1 - 1.7 8.9 12.2 4.3 7.6 4.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Tic110 PF16940.5 CDI74236.1 - 2.4 6.6 15.5 0.16 10.4 1.0 2.1 2 0 0 2 2 2 0 Chloroplast envelope transporter DUF572 PF04502.13 CDI74236.1 - 3.6 7.1 18.3 5.4 6.5 18.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4131 PF13567.6 CDI74236.1 - 3.9 7.1 8.4 0.27 10.9 0.4 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) SARAF PF06682.12 CDI74236.1 - 4.2 6.9 15.6 6 6.4 14.2 2.0 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis WBP-1 PF11669.8 CDI74236.1 - 4.7 7.9 18.2 1.1 10.0 5.9 2.7 1 1 2 3 3 3 0 WW domain-binding protein 1 PCNP PF15473.6 CDI74236.1 - 5.5 7.7 24.3 0.047 14.4 12.3 2.2 2 1 0 2 2 2 0 PEST, proteolytic signal-containing nuclear protein family Mem_trans PF03547.18 CDI74236.1 - 6.2 5.1 8.2 0.98 7.7 3.8 1.8 2 0 0 2 2 2 0 Membrane transport protein UPF0542 PF15086.6 CDI74236.1 - 6.4 6.8 6.0 2.8 7.9 0.2 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 Ku_PK_bind PF08785.11 CDI74238.1 - 1.3e-12 47.9 10.0 4.1e-06 26.9 1.2 4.3 3 1 1 4 4 4 3 Ku C terminal domain like RskA PF10099.9 CDI74238.1 - 5.2e-05 23.6 12.9 5.2e-05 23.6 12.9 3.0 2 1 1 3 3 2 2 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI74238.1 - 0.092 11.7 21.3 0.37 9.7 10.6 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM60A PF15396.6 CDI74238.1 - 0.096 12.7 11.3 0.63 10.0 3.5 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Lin-8 PF03353.15 CDI74238.1 - 0.21 11.1 22.4 0.1 12.1 9.7 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist GET2 PF08690.10 CDI74238.1 - 0.64 9.6 22.4 1.8 8.2 12.3 2.2 2 0 0 2 2 2 0 GET complex subunit GET2 Rgp1 PF08737.10 CDI74238.1 - 0.64 9.1 15.0 0.52 9.4 4.9 2.1 2 0 0 2 2 2 0 Rgp1 MMR1 PF08505.10 CDI74238.1 - 1.3 9.2 24.2 0.15 12.3 8.6 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein DUF4813 PF16072.5 CDI74238.1 - 1.8 8.1 15.5 0.48 10.0 4.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4813) Pex14_N PF04695.13 CDI74238.1 - 4 8.1 43.2 3.8 8.1 7.1 2.9 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Porin_4 PF13609.6 CDI74238.1 - 5.4 6.7 16.9 1.8 8.3 2.3 2.3 2 0 0 2 2 2 0 Gram-negative porin RR_TM4-6 PF06459.12 CDI74238.1 - 7.1 6.4 21.3 4 7.2 1.8 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 CDI74238.1 - 8.3 5.5 8.6 7.6 5.7 1.4 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter Exonuc_VII_L PF02601.15 CDI74240.1 - 0.056 13.0 43.5 0.068 12.7 43.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Caldesmon PF02029.15 CDI74240.1 - 8.5 5.0 42.1 11 4.6 42.1 1.2 1 0 0 1 1 1 0 Caldesmon N6_N4_Mtase PF01555.18 CDI74241.1 - 4.4 6.9 9.4 59 3.3 0.0 3.9 3 2 0 3 3 3 0 DNA methylase REPA_OB_2 PF16900.5 CDI74242.1 - 2.2e-29 101.3 0.0 2.9e-14 52.8 0.0 2.3 1 1 1 2 2 2 2 Replication protein A OB domain DUF2857 PF11198.8 CDI74242.1 - 0.057 13.2 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2857) DUF3306 PF11748.8 CDI74242.1 - 4.6 8.1 7.7 2.7 8.9 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) IMP2_N PF18590.1 CDI74243.1 - 1.6e-14 54.2 0.0 1.6e-14 54.2 0.0 1.8 2 0 0 2 2 2 1 Immune Mapped Protein 2 (IMP2) N-terminal domain WTX PF09422.10 CDI74243.1 - 0.18 10.9 13.7 0.23 10.5 13.7 1.1 1 0 0 1 1 1 0 WTX protein Presenilin PF01080.17 CDI74243.1 - 0.21 10.3 7.0 0.23 10.2 7.0 1.1 1 0 0 1 1 1 0 Presenilin Prothymosin PF03247.14 CDI74243.1 - 2.9 8.4 27.8 5 7.6 27.8 1.4 1 0 0 1 1 1 0 Prothymosin/parathymosin family FAM60A PF15396.6 CDI74243.1 - 2.9 7.9 8.9 3.9 7.4 8.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Ferlin_C PF16165.5 CDI74243.1 - 3.1 7.7 9.8 6.2 6.7 9.8 1.6 1 0 0 1 1 1 0 Ferlin C-terminus Raftlin PF15250.6 CDI74243.1 - 3.3 6.3 11.9 4.6 5.9 11.9 1.2 1 0 0 1 1 1 0 Raftlin IMUP PF15761.5 CDI74244.1 - 0.0033 18.1 18.9 0.0033 18.1 18.9 6.5 4 3 1 5 5 5 1 Immortalisation up-regulated protein RskA PF10099.9 CDI74244.1 - 0.0053 17.1 10.9 0.0053 17.1 10.9 7.5 2 2 1 3 3 3 1 Anti-sigma-K factor rskA HemX PF04375.14 CDI74245.1 - 0.0029 17.0 9.2 0.0035 16.7 9.2 1.0 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase PTPRCAP PF15713.5 CDI74245.1 - 0.011 16.0 7.5 0.012 15.9 7.5 1.0 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF2722 PF10846.8 CDI74245.1 - 0.024 13.6 5.2 0.023 13.6 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF5349 PF17298.2 CDI74245.1 - 0.031 14.0 2.8 0.036 13.8 2.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5349) Spt20 PF12090.8 CDI74245.1 - 0.04 13.5 10.2 0.045 13.3 10.2 1.1 1 0 0 1 1 1 0 Spt20 family Big_4 PF07532.11 CDI74245.1 - 0.046 13.5 0.0 0.063 13.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 4) FTZ PF03867.14 CDI74245.1 - 0.071 12.6 5.9 0.085 12.4 5.9 1.0 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region TFIIA PF03153.13 CDI74245.1 - 0.2 11.6 10.1 0.22 11.5 10.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI74245.1 - 0.4 9.2 9.5 0.48 8.9 9.5 1.0 1 0 0 1 1 1 0 Macoilin family GET2 PF08690.10 CDI74245.1 - 0.47 10.1 5.2 0.55 9.8 5.2 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 PepSY_TM PF03929.16 CDI74245.1 - 0.47 10.1 1.1 0.55 9.8 1.1 1.1 1 0 0 1 1 1 0 PepSY-associated TM region DUF4407 PF14362.6 CDI74245.1 - 1.1 8.5 8.9 1.3 8.3 8.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pup PF05639.11 CDI74245.1 - 1.4 9.9 11.3 0.34 11.8 7.6 1.9 1 1 1 2 2 2 0 Pup-like protein BAF1_ABF1 PF04684.13 CDI74245.1 - 1.5 7.8 9.0 1.7 7.6 9.0 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor K_channel_TID PF07941.11 CDI74245.1 - 2.5 8.6 19.1 1.1 9.7 6.2 2.3 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Presenilin PF01080.17 CDI74245.1 - 6.5 5.4 6.1 7.6 5.2 6.1 1.1 1 0 0 1 1 1 0 Presenilin rve PF00665.26 CDI74246.1 - 6.3e-11 42.5 0.0 8.4e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.6 CDI74247.1 - 1.3e-06 29.0 0.0 2.6e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI74247.1 - 2.7e-06 27.9 0.0 5.1e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 CDI74247.1 - 0.00093 19.0 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.20 CDI74247.1 - 0.073 13.4 0.0 0.4 11.0 0.0 2.1 3 0 0 3 3 3 0 Retroviral aspartyl protease DUF1758 PF05585.12 CDI74247.1 - 0.2 11.4 0.0 0.32 10.7 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase (DUF1758) RT_RNaseH_2 PF17919.1 CDI74248.1 - 5.4e-23 80.9 0.1 8.8e-23 80.2 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI74248.1 - 1.7e-21 76.5 0.0 2.7e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDI74248.1 - 3.2e-10 39.9 0.1 5.8e-10 39.1 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2722 PF10846.8 CDI74253.1 - 0.00082 18.4 13.4 0.0011 18.0 13.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Activator_LAG-3 PF11498.8 CDI74253.1 - 0.0032 16.5 19.2 0.0044 16.1 19.2 1.2 1 0 0 1 1 1 1 Transcriptional activator LAG-3 DDHD PF02862.17 CDI74253.1 - 0.006 16.8 6.0 0.0067 16.6 6.0 1.2 1 0 0 1 1 1 1 DDHD domain TraT PF05818.12 CDI74253.1 - 0.013 15.2 9.5 0.019 14.6 9.5 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Macoilin PF09726.9 CDI74253.1 - 0.05 12.2 7.2 0.063 11.8 7.2 1.2 1 0 0 1 1 1 0 Macoilin family PAT1 PF09770.9 CDI74253.1 - 0.31 9.3 17.4 0.35 9.1 17.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4746 PF15928.5 CDI74253.1 - 0.51 9.7 11.7 0.077 12.4 8.1 1.4 2 0 0 2 2 1 0 Domain of unknown function (DUF4746) eIF-3_zeta PF05091.12 CDI74253.1 - 0.52 9.2 14.6 0.69 8.8 14.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ArsP_2 PF11449.8 CDI74253.1 - 0.61 9.2 4.3 0.84 8.8 4.3 1.1 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter SID-1_RNA_chan PF13965.6 CDI74253.1 - 0.86 7.9 2.8 1.1 7.6 2.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NARP1 PF12569.8 CDI74253.1 - 0.9 8.4 13.6 1.2 8.0 13.6 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DcuA_DcuB PF03605.14 CDI74253.1 - 1.3 7.9 5.6 1.8 7.4 5.6 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Zip PF02535.22 CDI74253.1 - 2 7.5 4.3 2.3 7.4 4.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 CDI74253.1 - 2.4 6.9 15.8 3 6.5 15.8 1.1 1 0 0 1 1 1 0 Presenilin UPF0560 PF10577.9 CDI74253.1 - 2.5 6.5 16.6 3.5 6.0 16.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Neur_chan_memb PF02932.16 CDI74253.1 - 3 7.8 8.3 4.4 7.3 8.3 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_S49_N PF08496.10 CDI74253.1 - 3.1 7.8 13.8 4.6 7.3 13.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal ALMT PF11744.8 CDI74253.1 - 3.3 6.5 9.6 4.1 6.1 9.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Hydin_ADK PF17213.3 CDI74253.1 - 3.6 7.8 17.9 7.6 6.8 17.9 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain PBP_sp32 PF07222.12 CDI74253.1 - 4.9 6.5 16.8 8.2 5.8 16.8 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Band_3_cyto PF07565.13 CDI74253.1 - 5 6.9 9.6 6.4 6.5 9.6 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Usp PF00582.26 CDI74253.1 - 6.7 7.2 10.3 12 6.4 10.3 1.5 1 0 0 1 1 1 0 Universal stress protein family GREB1 PF15782.5 CDI74253.1 - 6.7 3.7 18.1 8.6 3.3 18.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Latrophilin PF02354.16 CDI74253.1 - 7.3 5.5 11.4 12 4.8 11.4 1.3 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region Connexin PF00029.19 CDI74253.1 - 7.5 6.2 9.5 10 5.8 9.5 1.2 1 0 0 1 1 1 0 Connexin MMR1 PF08505.10 CDI74253.1 - 8.9 6.5 18.3 13 6.0 18.3 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein R_equi_Vir PF05526.11 CDI74253.1 - 9.8 6.0 11.2 15 5.4 11.2 1.2 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein BOP1NT PF08145.12 CDI74255.1 - 5.3e-07 29.8 1.8 1.6e-06 28.2 0.1 2.3 2 1 0 2 2 2 1 BOP1NT (NUC169) domain SR-25 PF10500.9 CDI74255.1 - 9.2e-07 28.7 7.6 9.2e-07 28.7 7.6 2.7 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein DUF4207 PF13904.6 CDI74255.1 - 0.11 12.2 26.3 0.055 13.2 10.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) AAA_23 PF13476.6 CDI74255.1 - 0.19 12.2 10.7 0.3 11.5 1.6 2.2 2 0 0 2 2 2 0 AAA domain BP28CT PF08146.12 CDI74255.1 - 0.46 10.3 4.7 0.55 10.1 0.8 2.3 2 0 0 2 2 2 0 BP28CT (NUC211) domain PigN PF04987.14 CDI74255.1 - 1.7 7.4 5.1 1.5 7.6 2.0 2.1 2 0 0 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) Suf PF05843.14 CDI74255.1 - 1.8 8.5 22.7 1.6 8.6 1.4 2.9 2 1 2 4 4 4 0 Suppressor of forked protein (Suf) Neuraminidase PF18413.1 CDI74255.1 - 2 8.0 9.3 1.3 8.7 4.6 2.2 2 0 0 2 2 2 0 Neuraminidase-like domain DUF2489 PF10675.9 CDI74255.1 - 2.3 8.1 23.0 0.65 9.9 5.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) Syntaxin-18_N PF10496.9 CDI74255.1 - 2.9 8.2 11.8 5.5 7.3 0.2 3.3 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus WASH-7_C PF14746.6 CDI74255.1 - 3.3 7.4 12.8 5.3 6.7 4.8 2.4 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal NTP_transf_3 PF12804.7 CDI74255.1 - 6.8 7.0 16.0 1.7 9.0 8.8 2.3 1 1 1 2 2 2 0 MobA-like NTP transferase domain DUF2722 PF10846.8 CDI74255.1 - 8 5.3 32.5 0.14 11.1 4.5 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2722) WBP-1 PF11669.8 CDI74255.1 - 8 7.2 5.8 45 4.7 0.6 2.5 2 0 0 2 2 2 0 WW domain-binding protein 1 SARAF PF06682.12 CDI74256.1 - 2.3e-06 27.5 10.2 2.9e-06 27.2 10.2 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Zip PF02535.22 CDI74256.1 - 4e-06 26.3 4.4 5.3e-06 25.9 4.4 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF5427 PF10310.9 CDI74256.1 - 7.2e-06 25.2 13.6 7.9e-06 25.1 13.6 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5427) RR_TM4-6 PF06459.12 CDI74256.1 - 2.4e-05 24.3 16.9 3e-05 24.0 16.9 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 CSG2 PF16965.5 CDI74256.1 - 4.7e-05 22.5 0.9 5.7e-05 22.2 0.9 1.1 1 0 0 1 1 1 1 Ceramide synthase regulator DUF913 PF06025.12 CDI74256.1 - 0.00037 19.6 4.3 0.00045 19.3 4.3 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) SID-1_RNA_chan PF13965.6 CDI74256.1 - 0.00054 18.5 1.7 0.00059 18.4 1.7 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 SART-1 PF03343.13 CDI74256.1 - 0.0028 16.3 17.7 0.003 16.2 17.7 1.0 1 0 0 1 1 1 1 SART-1 family DREPP PF05558.12 CDI74256.1 - 0.0065 16.4 2.3 0.0085 16.0 2.3 1.1 1 0 0 1 1 1 1 DREPP plasma membrane polypeptide DUF2370 PF10176.9 CDI74256.1 - 0.0066 16.1 5.1 0.0098 15.6 5.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) FAM60A PF15396.6 CDI74256.1 - 0.0066 16.5 13.3 0.0083 16.1 13.3 1.1 1 0 0 1 1 1 1 Protein Family FAM60A RskA PF10099.9 CDI74256.1 - 0.0072 16.6 20.1 1.6 9.0 20.1 2.2 1 1 0 1 1 1 1 Anti-sigma-K factor rskA Ndc1_Nup PF09531.10 CDI74256.1 - 0.0082 14.9 18.8 0.012 14.4 18.8 1.2 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Neur_chan_memb PF02932.16 CDI74256.1 - 0.013 15.5 13.8 0.022 14.8 13.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TRAP_alpha PF03896.16 CDI74256.1 - 0.017 14.4 5.9 0.026 13.7 5.9 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BORG_CEP PF14957.6 CDI74256.1 - 0.018 16.2 10.4 0.021 16.0 10.4 1.2 1 0 0 1 1 1 0 Cdc42 effector Velvet PF11754.8 CDI74256.1 - 0.022 14.7 16.0 0.028 14.4 16.0 1.2 1 0 0 1 1 1 0 Velvet factor DUF2828 PF11443.8 CDI74256.1 - 0.027 12.6 14.9 0.032 12.4 14.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) LAP1C PF05609.12 CDI74256.1 - 0.031 13.4 19.4 0.04 13.0 19.4 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) V_ATPase_I PF01496.19 CDI74256.1 - 0.042 11.8 20.6 0.053 11.4 20.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family O-antigen_lig PF13425.6 CDI74256.1 - 0.047 12.5 7.7 0.063 12.1 7.7 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein TCP PF03634.13 CDI74256.1 - 0.065 13.8 19.8 0.079 13.5 19.8 1.2 1 0 0 1 1 1 0 TCP family transcription factor Peroxin-3 PF04882.12 CDI74256.1 - 0.08 11.9 20.2 0.1 11.6 20.2 1.1 1 0 0 1 1 1 0 Peroxin-3 DUF2126 PF09899.9 CDI74256.1 - 0.15 10.1 10.0 0.19 9.7 10.0 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Sec62 PF03839.16 CDI74256.1 - 0.16 11.5 16.5 0.21 11.1 16.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 NicO PF03824.16 CDI74256.1 - 0.17 11.2 1.5 0.33 10.2 1.5 1.4 1 1 0 1 1 1 0 High-affinity nickel-transport protein Otopetrin PF03189.13 CDI74256.1 - 0.22 10.3 8.6 0.32 9.8 8.6 1.4 1 0 0 1 1 1 0 Otopetrin Kei1 PF08552.11 CDI74256.1 - 0.24 11.3 12.8 0.78 9.6 12.9 1.9 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 ALMT PF11744.8 CDI74256.1 - 0.31 9.8 17.3 0.39 9.5 17.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM222A PF15258.6 CDI74256.1 - 0.44 9.6 35.6 0.5 9.4 35.6 1.1 1 0 0 1 1 1 0 Protein family of FAM222A Endostatin PF06482.11 CDI74256.1 - 0.45 9.9 20.9 0.59 9.5 20.9 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CLN3 PF02487.17 CDI74256.1 - 0.49 9.4 18.3 1.1 8.2 18.4 1.5 1 1 0 1 1 1 0 CLN3 protein CBP_BcsG PF11658.8 CDI74256.1 - 0.53 8.6 14.4 0.62 8.4 14.4 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DUF2407_C PF13373.6 CDI74256.1 - 0.63 10.2 9.5 0.91 9.7 9.5 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain GREB1 PF15782.5 CDI74256.1 - 0.67 7.0 21.0 0.74 6.9 21.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 CDI74256.1 - 0.71 8.8 24.8 0.92 8.5 24.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 HCO3_cotransp PF00955.21 CDI74256.1 - 0.87 8.3 7.8 1.1 8.0 7.8 1.1 1 0 0 1 1 1 0 HCO3- transporter family CDC45 PF02724.14 CDI74256.1 - 1.2 7.3 21.8 1.6 6.9 21.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2052 PF09747.9 CDI74256.1 - 1.5 8.9 27.8 2 8.5 27.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Gti1_Pac2 PF09729.9 CDI74256.1 - 1.6 8.8 19.8 2.3 8.2 19.8 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Cellulose_synt PF03552.14 CDI74256.1 - 1.7 7.0 7.2 2.1 6.7 7.2 1.2 1 0 0 1 1 1 0 Cellulose synthase Exonuc_VII_L PF02601.15 CDI74256.1 - 2.1 7.9 22.3 2.6 7.5 22.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Dapper PF15268.6 CDI74256.1 - 2.1 7.1 27.0 2.5 6.8 27.0 1.0 1 0 0 1 1 1 0 Dapper CDK5_activator PF03261.15 CDI74256.1 - 2.5 7.6 18.0 3.1 7.3 18.0 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein LMBR1 PF04791.16 CDI74256.1 - 2.6 6.9 10.5 3.3 6.5 10.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein PA26 PF04636.13 CDI74256.1 - 3 6.7 17.5 3.8 6.3 17.5 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF3295 PF11702.8 CDI74256.1 - 3.1 7.1 23.5 3.9 6.7 23.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DcuA_DcuB PF03605.14 CDI74256.1 - 3.3 6.5 11.6 0.2 10.5 1.1 2.1 1 1 1 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Hamartin PF04388.12 CDI74256.1 - 4.3 5.9 22.0 5.2 5.6 22.0 1.0 1 0 0 1 1 1 0 Hamartin protein CemA PF03040.14 CDI74256.1 - 4.3 7.2 8.4 5.1 7.0 8.4 1.1 1 0 0 1 1 1 0 CemA family DNA_pack_N PF02500.15 CDI74256.1 - 5.5 6.7 12.7 7.5 6.3 12.7 1.1 1 0 0 1 1 1 0 Probable DNA packing protein, N-terminus XRN_M PF17846.1 CDI74256.1 - 5.9 5.7 19.2 7.5 5.4 19.2 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Raftlin PF15250.6 CDI74256.1 - 7 5.3 22.6 9.1 4.9 22.6 1.0 1 0 0 1 1 1 0 Raftlin Orf78 PF06024.12 CDI74256.1 - 7.5 6.9 18.5 0.09 13.1 2.5 2.3 1 1 1 2 2 1 0 Orf78 (ac78) SAPS PF04499.15 CDI74256.1 - 8 5.1 19.8 10 4.8 19.8 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2347 PF09804.9 CDI74256.1 - 8.4 5.9 15.5 16 5.0 15.5 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF4045 PF13254.6 CDI74256.1 - 10 5.7 24.1 13 5.3 24.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Syja_N PF02383.18 CDI74257.1 - 3.3e-16 59.5 3.6 3.3e-16 59.5 3.6 3.5 3 1 0 3 3 3 1 SacI homology domain RskA PF10099.9 CDI74257.1 - 6.4e-07 29.8 24.9 1.9e-06 28.3 10.0 9.4 2 2 6 8 8 8 3 Anti-sigma-K factor rskA SARAF PF06682.12 CDI74257.1 - 0.00036 20.3 1.5 0.00036 20.3 1.5 5.1 3 1 1 4 4 4 1 SOCE-associated regulatory factor of calcium homoeostasis RskA PF10099.9 CDI74258.1 - 0.0038 17.5 22.4 0.0038 17.5 22.4 9.6 3 2 4 7 7 7 2 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI74259.1 - 4.2 7.3 128.2 1.3 8.9 23.1 3.1 1 1 2 3 3 3 0 Transcription factor IIA, alpha/beta subunit Pentapeptide_4 PF13599.6 CDI74260.1 - 7.6e-12 45.2 0.1 0.00096 19.3 0.1 3.7 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 CDI74260.1 - 0.015 14.9 0.0 5.3 6.8 0.0 4.2 1 1 0 1 1 1 0 Pentapeptide repeats (8 copies) RskA PF10099.9 CDI74261.1 - 0.0035 17.7 9.0 0.0035 17.7 9.0 2.1 1 1 1 2 2 2 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI74261.1 - 0.009 16.1 42.6 0.01 15.9 42.6 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Pap_E4 PF02711.14 CDI74261.1 - 0.038 14.9 3.3 0.038 14.9 3.3 2.9 2 1 0 2 2 1 0 E4 protein MRP-S31 PF15433.6 CDI74261.1 - 0.14 11.8 22.9 0.17 11.5 22.9 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 DUF3357 PF11837.8 CDI74261.1 - 0.27 11.7 14.1 0.073 13.5 4.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) Peptidase_S49_N PF08496.10 CDI74261.1 - 0.58 10.2 10.7 0.98 9.5 10.7 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CCDC24 PF15669.5 CDI74261.1 - 0.75 9.6 27.5 2 8.2 17.0 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family eIF-3_zeta PF05091.12 CDI74261.1 - 1.6 7.6 20.6 2.2 7.2 20.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SYF2 PF08231.12 CDI74261.1 - 2.1 8.7 18.4 1.2 9.5 16.6 1.5 1 1 0 1 1 1 0 SYF2 splicing factor DUF4407 PF14362.6 CDI74261.1 - 2.9 7.1 14.5 3.9 6.8 14.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) O-antigen_lig PF13425.6 CDI74261.1 - 5.9 5.6 7.1 7.3 5.2 7.1 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Zn_peptidase PF04228.13 CDI74261.1 - 6 6.2 19.8 18 4.7 16.7 2.0 1 1 1 2 2 2 0 Putative neutral zinc metallopeptidase DUF979 PF06166.12 CDI74261.1 - 6.4 5.9 5.6 14 4.7 5.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF979) EphA2_TM PF14575.6 CDI74261.1 - 7.9 7.4 20.3 3.3 8.6 1.6 3.3 1 1 2 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain AF-4 PF05110.13 CDI74261.1 - 9.5 4.2 53.4 1.1 7.3 29.6 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Serinc PF03348.15 CDI74261.1 - 9.7 5.0 15.9 14 4.5 15.9 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) RskA PF10099.9 CDI74262.1 - 4.8e-05 23.7 0.0 4.8e-05 23.7 0.0 9.0 3 3 2 5 5 5 2 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI74262.1 - 0.0023 16.9 5.0 0.0023 16.9 5.0 6.2 4 3 1 5 5 5 1 Protein of unknown function (DUF2722) N6_N4_Mtase PF01555.18 CDI74262.1 - 0.12 12.0 0.0 1.2e+02 2.3 0.0 3.3 3 1 0 3 3 3 0 DNA methylase Utp14 PF04615.13 CDI74262.1 - 4.4 5.8 62.0 1.5 7.3 10.6 3.3 3 0 0 3 3 3 0 Utp14 protein PNTB PF02233.16 CDI74263.1 - 3e-133 445.1 27.0 6.3e-87 292.4 3.1 3.2 3 1 1 4 4 4 2 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 CDI74263.1 - 6.5e-67 224.9 0.4 2.7e-66 222.9 0.2 2.0 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CDI74263.1 - 7.4e-20 71.6 0.0 1.4e-19 70.8 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain 2-Hacid_dh_C PF02826.19 CDI74263.1 - 2.2e-07 30.4 0.0 4.5e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PNTB_4TM PF12769.7 CDI74263.1 - 0.0021 18.5 8.2 0.0021 18.5 8.2 5.1 3 2 1 4 4 4 1 4TM region of pyridine nucleotide transhydrogenase, mitoch TPP_enzyme_M PF00205.22 CDI74263.1 - 0.0027 17.4 0.3 0.071 12.8 0.1 3.2 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain NAD_binding_2 PF03446.15 CDI74263.1 - 0.016 15.4 0.1 0.1 12.8 0.0 2.1 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Methyltransf_11 PF08241.12 CDI74263.1 - 0.024 15.3 0.1 0.091 13.4 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain DUF2325 PF10087.9 CDI74263.1 - 0.034 14.3 0.1 0.11 12.6 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2325) SNF2_N PF00176.23 CDI74265.1 - 1.8e-22 79.6 3.8 9e-13 47.7 3.9 3.3 2 1 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 CDI74265.1 - 5.6e-12 46.0 0.0 5.6e-12 46.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain TFIIA PF03153.13 CDI74265.1 - 2.4e-05 24.6 20.0 2.4e-05 24.6 20.0 2.3 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI74265.1 - 0.42 8.8 14.8 0.67 8.2 14.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Serinc PF03348.15 CDI74265.1 - 0.48 9.3 1.3 0.84 8.5 1.3 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) SID-1_RNA_chan PF13965.6 CDI74265.1 - 0.5 8.7 0.9 0.74 8.2 0.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 CDI74265.1 - 1.6 7.6 12.3 4.5 6.2 12.3 1.7 1 0 0 1 1 1 0 Solute carrier family 12 CIAPIN1 PF05093.13 CDI74265.1 - 2.5 8.7 11.9 9.1 6.9 11.9 2.0 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis ALMT PF11744.8 CDI74265.1 - 3.6 6.3 9.7 24 3.6 10.8 1.7 2 0 0 2 2 2 0 Aluminium activated malate transporter V_ATPase_I PF01496.19 CDI74265.1 - 3.8 5.3 10.7 5.9 4.7 10.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2052 PF09747.9 CDI74265.1 - 7.2 6.7 18.6 17 5.5 14.9 2.6 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) eIF-3_zeta PF05091.12 CDI74265.1 - 9.6 5.0 17.4 17 4.2 17.4 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Melibiase_2 PF16499.5 CDI74266.1 - 1.1e-05 24.8 0.0 3.5e-05 23.1 0.0 1.9 1 1 0 1 1 1 1 Alpha galactosidase A Macoilin PF09726.9 CDI74266.1 - 1.7 7.1 20.2 2.7 6.4 20.2 1.2 1 0 0 1 1 1 0 Macoilin family Miga PF10265.9 CDI74266.1 - 2.2 7.1 6.6 11 4.8 7.8 1.5 2 0 0 2 2 2 0 Mitoguardin Shadoo PF14999.6 CDI74267.1 - 0.011 15.9 0.6 0.014 15.5 0.6 1.2 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective PAT1 PF09770.9 CDI74267.1 - 1.1 7.5 48.2 1.4 7.1 48.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Nop53 PF07767.11 CDI74267.1 - 3.5 6.9 39.7 4.6 6.5 39.7 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Exonuc_VII_L PF02601.15 CDI74267.1 - 5.3 6.5 32.2 7.4 6.0 32.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit SID-1_RNA_chan PF13965.6 CDI74267.1 - 6.9 4.9 9.8 10 4.4 9.8 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GREB1 PF15782.5 CDI74267.1 - 9.1 3.2 31.3 11 3.0 31.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIA PF03153.13 CDI74268.1 - 0.63 10.0 41.1 0.77 9.7 41.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NMT PF01233.19 CDI74270.1 - 2e-05 24.5 0.0 2.7e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain TFIIA PF03153.13 CDI74272.1 - 1.1e-05 25.7 58.3 1.4e-05 25.3 58.3 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CDC27 PF09507.10 CDI74272.1 - 0.00037 20.0 36.2 0.00041 19.9 36.2 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 Dapper PF15268.6 CDI74272.1 - 1.5 7.6 49.5 1.7 7.4 49.5 1.0 1 0 0 1 1 1 0 Dapper SWI-SNF_Ssr4 PF08549.10 CDI74272.1 - 1.7 7.2 37.0 2.4 6.7 37.0 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Nucleo_P87 PF07267.11 CDI74272.1 - 4.5 6.0 47.4 5.6 5.7 47.4 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF2076 PF09849.9 CDI74273.1 - 0.0037 17.3 18.5 0.0037 17.3 18.5 2.4 4 0 0 4 4 4 1 Uncharacterized protein conserved in bacteria (DUF2076) DUF1645 PF07816.11 CDI74273.1 - 0.0058 17.2 15.1 0.22 12.1 1.6 3.6 4 0 0 4 4 4 2 Protein of unknown function (DUF1645) Secretin_N_2 PF07655.13 CDI74273.1 - 0.35 11.4 26.3 0.65 10.6 6.5 3.3 3 0 0 3 3 3 0 Secretin N-terminal domain Acyl-CoA_dh_2 PF08028.11 CDI74273.1 - 1.2 9.5 11.3 16 5.8 4.5 3.2 3 0 0 3 3 3 0 Acyl-CoA dehydrogenase, C-terminal domain DUF2681 PF10883.8 CDI74273.1 - 1.3 9.5 18.5 0.91 10.0 3.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DivIC PF04977.15 CDI74273.1 - 1.7 8.5 12.8 0.93 9.3 1.7 2.2 2 0 0 2 2 2 0 Septum formation initiator RAB3GAP2_N PF14655.6 CDI74273.1 - 5.2 6.2 9.8 0.58 9.4 0.8 2.4 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus RskA PF10099.9 CDI74273.1 - 5.7 7.2 30.6 0.037 14.3 1.9 3.1 2 1 1 3 3 3 0 Anti-sigma-K factor rskA Hid1 PF12722.7 CDI74274.1 - 0.39 8.8 26.1 0.44 8.6 26.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GAGA_bind PF06217.12 CDI74274.1 - 3.2 8.0 23.1 4.9 7.3 23.1 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family BUD22 PF09073.10 CDI74276.1 - 0.00015 21.3 14.1 0.00021 20.8 14.1 1.1 1 0 0 1 1 1 1 BUD22 SR-25 PF10500.9 CDI74276.1 - 0.001 18.8 24.1 0.0031 17.2 11.7 2.2 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein Roughex PF06020.11 CDI74276.1 - 0.0015 17.7 13.5 0.0027 16.9 13.5 1.3 1 0 0 1 1 1 1 Drosophila roughex protein Plasmodium_Vir PF05795.11 CDI74276.1 - 0.0081 15.6 6.4 0.011 15.2 6.4 1.2 1 0 0 1 1 1 1 Plasmodium vivax Vir protein XAP5 PF04921.14 CDI74276.1 - 0.025 14.4 15.2 0.39 10.5 0.4 2.1 2 0 0 2 2 2 0 XAP5, circadian clock regulator SPX PF03105.19 CDI74276.1 - 0.04 13.8 16.3 0.055 13.4 16.3 1.1 1 0 0 1 1 1 0 SPX domain DDRGK PF09756.9 CDI74276.1 - 0.11 12.0 13.1 0.18 11.4 13.1 1.3 1 0 0 1 1 1 0 DDRGK domain eIF3_subunit PF08597.10 CDI74276.1 - 0.17 11.7 16.7 0.38 10.6 16.7 1.6 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit SpoIIP PF07454.11 CDI74276.1 - 0.19 11.1 13.5 0.045 13.2 8.6 1.9 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DcuA_DcuB PF03605.14 CDI74276.1 - 0.41 9.5 1.4 0.65 8.8 1.4 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Presenilin PF01080.17 CDI74276.1 - 0.49 9.1 21.1 0.094 11.5 10.5 2.0 2 0 0 2 2 2 0 Presenilin CBP_BcsG PF11658.8 CDI74276.1 - 0.57 8.5 7.1 1.1 7.6 7.1 1.4 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DUF719 PF05334.13 CDI74276.1 - 0.7 10.1 18.9 0.54 10.4 10.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF719) CCSAP PF15748.5 CDI74276.1 - 0.83 9.8 24.2 0.073 13.2 8.9 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Eapp_C PF10238.9 CDI74276.1 - 0.98 9.5 15.5 0.089 12.9 9.2 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein RskA PF10099.9 CDI74276.1 - 1 9.7 20.9 2.6 8.3 10.0 2.5 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Connexin PF00029.19 CDI74276.1 - 1.5 8.6 8.9 0.16 11.7 4.3 1.7 2 0 0 2 2 2 0 Connexin FemAB PF02388.16 CDI74276.1 - 1.6 7.5 12.1 2.6 6.8 12.1 1.3 1 0 0 1 1 1 0 FemAB family IHABP4_N PF16174.5 CDI74276.1 - 1.6 9.3 18.8 0.42 11.2 12.0 2.2 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal RR_TM4-6 PF06459.12 CDI74276.1 - 2 8.2 17.1 0.25 11.1 11.3 1.9 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.8 CDI74276.1 - 2 7.1 15.3 0.31 9.8 9.2 2.0 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF4637 PF15470.6 CDI74276.1 - 2.6 7.8 16.6 0.089 12.5 9.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) FHIPEP PF00771.20 CDI74276.1 - 2.6 6.4 8.7 0.66 8.4 5.8 1.4 2 0 0 2 2 2 0 FHIPEP family Gti1_Pac2 PF09729.9 CDI74276.1 - 2.7 8.1 16.3 1.8 8.6 5.8 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family Asp-B-Hydro_N PF05279.11 CDI74276.1 - 3.3 7.7 13.7 6.1 6.8 13.7 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region EOS1 PF12326.8 CDI74276.1 - 3.8 7.4 10.2 2.4 8.1 4.3 2.2 2 0 0 2 2 2 0 N-glycosylation protein CPSF100_C PF13299.6 CDI74276.1 - 4.4 7.5 19.9 0.85 9.8 11.7 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal CobT PF06213.12 CDI74276.1 - 4.7 6.5 23.4 0.29 10.5 16.8 2.0 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT TFB6 PF17110.5 CDI74276.1 - 5.6 6.7 8.4 11 5.7 8.4 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Secretin_N_2 PF07655.13 CDI74276.1 - 5.9 7.5 19.9 4.1 8.0 12.5 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain DUF5523 PF17661.1 CDI74276.1 - 6 6.5 17.5 0.82 9.3 12.6 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5523) DUF4674 PF15719.5 CDI74276.1 - 7.4 6.6 19.1 3.2 7.7 7.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4674) Ureide_permease PF07168.11 CDI74276.1 - 7.5 5.2 9.0 1.5 7.5 2.9 2.0 2 0 0 2 2 2 0 Ureide permease TRAP_alpha PF03896.16 CDI74276.1 - 7.8 5.6 10.6 14 4.8 10.6 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit MDM31_MDM32 PF08118.11 CDI74276.1 - 8.1 5.0 7.5 14 4.2 7.5 1.4 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Maf1 PF09174.10 CDI74276.1 - 8.4 6.5 12.9 5.3 7.2 3.2 2.2 2 0 0 2 2 2 0 Maf1 regulator Orf78 PF06024.12 CDI74276.1 - 8.6 6.7 10.8 4.2 7.7 5.3 2.3 2 0 0 2 2 2 0 Orf78 (ac78) BBP1_N PF15271.6 CDI74276.1 - 9.1 7.1 13.2 3.8 8.3 5.1 2.2 2 0 0 2 2 2 0 Spindle pole body component BBP1, Mps2-binding protein Methyltransf_32 PF13679.6 CDI74276.1 - 9.2 6.2 16.4 4.3 7.3 9.3 2.2 2 0 0 2 2 2 0 Methyltransferase domain TSP_1 PF00090.19 CDI74277.1 - 0.0023 18.1 12.8 0.036 14.3 0.2 4.5 3 0 0 3 3 3 3 Thrombospondin type 1 domain RskA PF10099.9 CDI74278.1 - 3.1e-05 24.3 2.2 3.1e-05 24.3 2.2 10.4 2 2 8 10 10 10 2 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI74278.1 - 0.39 10.3 0.0 0.15 11.7 13.5 7.1 5 3 2 7 7 7 0 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI74279.1 - 3.8 7.8 0.0 3 8.1 0.0 8.0 2 2 4 6 6 6 0 Anti-sigma-K factor rskA Macoilin PF09726.9 CDI74280.1 - 0.0016 17.1 39.0 0.0016 17.1 39.0 4.1 3 1 1 4 4 4 2 Macoilin family SART-1 PF03343.13 CDI74281.1 - 0.0061 15.2 12.8 0.0061 15.2 12.8 1.1 1 0 0 1 1 1 1 SART-1 family TFIIA PF03153.13 CDI74281.1 - 0.0083 16.2 34.3 0.01 15.9 34.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 CDI74281.1 - 0.079 12.8 14.2 0.092 12.6 14.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Otopetrin PF03189.13 CDI74281.1 - 0.21 10.4 1.7 0.17 10.6 1.7 1.2 1 0 0 1 1 1 0 Otopetrin MMR1 PF08505.10 CDI74281.1 - 0.38 11.0 21.0 0.59 10.4 21.0 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein PAT1 PF09770.9 CDI74281.1 - 0.46 8.7 18.5 0.46 8.7 18.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI74281.1 - 0.47 7.5 17.0 0.43 7.6 17.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TERB2 PF15101.6 CDI74281.1 - 0.57 10.2 14.2 0.82 9.7 14.2 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 eIF-3_zeta PF05091.12 CDI74281.1 - 0.69 8.8 12.6 0.79 8.6 12.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2052 PF09747.9 CDI74281.1 - 1.7 8.7 18.7 2.7 8.1 18.7 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Serinc PF03348.15 CDI74281.1 - 1.9 7.3 5.2 2.1 7.2 5.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Spore_coat_CotO PF14153.6 CDI74281.1 - 2.6 8.0 18.7 4.2 7.3 18.7 1.5 1 0 0 1 1 1 0 Spore coat protein CotO CLN3 PF02487.17 CDI74281.1 - 2.9 6.8 6.1 3.6 6.5 6.1 1.3 1 0 0 1 1 1 0 CLN3 protein PA26 PF04636.13 CDI74281.1 - 3.1 6.6 11.6 3.9 6.3 11.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Peptidase_S64 PF08192.11 CDI74281.1 - 3.1 6.2 11.5 3.7 5.9 11.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 NEMP PF10225.9 CDI74281.1 - 3.3 7.3 4.6 4.6 6.8 4.6 1.2 1 0 0 1 1 1 0 NEMP family NCOA_u2 PF16665.5 CDI74281.1 - 3.5 7.9 11.9 0.17 12.2 4.7 2.2 1 1 1 2 2 2 0 Unstructured region on nuclear receptor coactivator protein DUF1980 PF09323.10 CDI74281.1 - 8.6 6.2 6.4 18 5.2 6.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) HTH_15 PF12324.8 CDI74282.1 - 0.045 13.7 3.3 0.11 12.5 1.9 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase RVT_1 PF00078.27 CDI74283.1 - 8.8e-05 22.1 0.0 0.00018 21.1 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3563 PF12086.8 CDI74283.1 - 0.058 13.1 0.2 1.5 8.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3563) DUF2076 PF09849.9 CDI74284.1 - 0.004 17.2 8.0 0.004 17.2 8.0 3.6 2 1 2 4 4 4 1 Uncharacterized protein conserved in bacteria (DUF2076) CcmF_C PF16327.5 CDI74284.1 - 0.84 8.9 3.1 1.1 8.5 3.1 1.1 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal Tmp39 PF10271.9 CDI74284.1 - 1.1 8.2 4.8 1.7 7.5 4.8 1.4 1 0 0 1 1 1 0 Putative transmembrane protein N6_N4_Mtase PF01555.18 CDI74285.1 - 2.3e-05 24.2 0.0 4.7 6.9 0.0 7.7 9 2 0 9 9 9 1 DNA methylase RskA PF10099.9 CDI74285.1 - 0.0028 18.0 15.2 0.0028 18.0 15.2 35.1 9 7 14 27 27 27 6 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI74285.1 - 0.01 15.9 0.7 0.01 15.9 0.7 46.7 32 13 6 38 38 38 0 Unstructured region C-term to UIM in Ataxin3 PspB PF06667.12 CDI74286.1 - 0.022 14.8 3.0 0.022 14.8 3.0 2.5 3 0 0 3 3 3 0 Phage shock protein B AKAP95 PF04988.12 CDI74286.1 - 0.22 11.7 5.8 0.43 10.8 5.8 1.4 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) Chromo PF00385.24 CDI74287.1 - 5.1e-13 48.7 0.0 9e-13 47.9 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AUX_IAA PF02309.16 CDI74287.1 - 0.043 13.7 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 AUX/IAA family Cyclin PF08613.11 CDI74288.1 - 1.6e-17 64.4 0.1 1.6e-17 64.4 0.1 3.8 5 1 0 5 5 5 1 Cyclin ADP_PFK_GK PF04587.15 CDI74288.1 - 0.13 10.8 0.4 0.32 9.5 0.4 1.6 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region DUF4604 PF15377.6 CDI74290.1 - 0.0025 18.3 4.1 0.0029 18.0 4.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) IMUP PF15761.5 CDI74290.1 - 0.039 14.6 7.5 0.068 13.9 7.5 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 CDI74290.1 - 0.045 13.4 4.9 0.054 13.1 4.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Nop14 PF04147.12 CDI74290.1 - 0.12 10.6 8.0 0.12 10.5 8.0 1.0 1 0 0 1 1 1 0 Nop14-like family SpoIIIAH PF12685.7 CDI74290.1 - 0.15 11.9 5.5 0.18 11.6 5.5 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF2052 PF09747.9 CDI74290.1 - 0.23 11.6 10.2 0.3 11.2 10.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Zip PF02535.22 CDI74290.1 - 0.32 10.2 0.6 0.34 10.1 0.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PI3K_1B_p101 PF10486.9 CDI74290.1 - 1.9 6.2 5.3 2.2 6.0 5.3 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Presenilin PF01080.17 CDI74290.1 - 2.2 7.0 5.3 2.5 6.8 5.3 1.0 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 CDI74290.1 - 2.6 6.2 10.5 3.1 6.0 10.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 CDI74290.1 - 3.3 5.7 7.1 3.9 5.4 7.1 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Roughex PF06020.11 CDI74290.1 - 5.3 6.0 10.1 6.3 5.8 10.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein NrsF PF06532.11 CDI74291.1 - 0.93 9.2 6.5 1.2 8.8 6.5 1.1 1 0 0 1 1 1 0 Negative regulator of sigma F Presenilin PF01080.17 CDI74293.1 - 0.21 10.3 0.3 0.26 10.0 0.3 1.2 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CDI74293.1 - 1.1 9.2 6.5 1.9 8.4 6.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RAB3GAP2_N PF14655.6 CDI74293.1 - 3.9 6.6 6.9 5.1 6.2 6.9 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus SARAF PF06682.12 CDI74294.1 - 7 6.2 23.2 8.3 6.0 23.2 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Cytochrom_B558a PF05038.13 CDI74294.1 - 9.2 5.8 6.7 10 5.7 6.7 1.2 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit Spt20 PF12090.8 CDI74295.1 - 8.2e-06 25.6 21.4 8.2e-06 25.6 21.4 5.5 6 0 0 6 6 6 4 Spt20 family DUF2407_C PF13373.6 CDI74295.1 - 0.14 12.4 0.2 0.14 12.4 0.2 3.8 4 1 0 4 4 4 0 DUF2407 C-terminal domain TFB6 PF17110.5 CDI74295.1 - 0.29 10.9 18.8 0.24 11.1 0.4 3.9 3 1 1 4 4 4 0 Subunit 11 of the general transcription factor TFIIH RskA PF10099.9 CDI74295.1 - 1.2 9.4 66.0 1.6 9.0 0.3 6.1 3 1 2 5 5 5 0 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI74296.1 - 0.00051 19.7 19.2 0.00051 19.7 19.2 4.0 3 2 1 4 4 4 1 Spt20 family T2SSM PF04612.12 CDI74296.1 - 0.0088 16.1 4.2 0.0088 16.1 4.2 7.9 6 1 1 7 7 7 1 Type II secretion system (T2SS), protein M EphA2_TM PF14575.6 CDI74296.1 - 0.9 10.5 7.3 2.4 9.1 0.0 3.5 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain V_ATPase_I PF01496.19 CDI74296.1 - 1.5 6.6 15.5 0.13 10.1 3.9 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family GPCR_chapero_1 PF11904.8 CDI74296.1 - 1.7 8.0 10.2 0.44 9.9 2.2 2.5 2 0 0 2 2 2 0 GPCR-chaperone PX PF00787.24 CDI74298.1 - 2.7e-15 56.3 0.0 8.3e-15 54.8 0.0 1.8 2 0 0 2 2 2 1 PX domain RskA PF10099.9 CDI74298.1 - 0.0013 19.1 14.5 0.0013 19.1 14.5 5.6 3 2 2 5 5 5 4 Anti-sigma-K factor rskA Syja_N PF02383.18 CDI74299.1 - 8.2e-10 38.5 22.3 2.5e-09 36.9 14.8 3.8 2 1 0 2 2 2 1 SacI homology domain Connexin PF00029.19 CDI74299.1 - 3e-05 23.9 18.6 0.012 15.4 1.2 3.1 3 0 0 3 3 3 2 Connexin DUF2722 PF10846.8 CDI74299.1 - 9.6e-05 21.5 32.3 0.00062 18.8 7.4 3.8 4 1 0 4 4 2 2 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI74299.1 - 0.0014 18.7 38.0 0.0014 18.7 38.0 3.1 2 1 1 3 3 2 1 Transcription factor IIA, alpha/beta subunit SpoIIP PF07454.11 CDI74299.1 - 0.002 17.6 24.8 0.2 11.1 1.4 3.2 3 0 0 3 3 3 3 Stage II sporulation protein P (SpoIIP) MecA PF05389.12 CDI74299.1 - 0.0027 17.4 20.8 0.11 12.1 0.8 3.2 3 0 0 3 3 3 2 Negative regulator of genetic competence (MecA) Suf PF05843.14 CDI74299.1 - 0.0035 17.4 6.6 0.0035 17.4 6.6 3.9 4 0 0 4 4 4 2 Suppressor of forked protein (Suf) FHIPEP PF00771.20 CDI74299.1 - 0.0054 15.3 22.2 0.22 9.9 3.7 3.2 3 0 0 3 3 3 3 FHIPEP family Presenilin PF01080.17 CDI74299.1 - 0.009 14.8 32.6 0.05 12.4 14.2 2.8 2 1 1 3 3 3 2 Presenilin RskA PF10099.9 CDI74299.1 - 0.014 15.7 26.4 0.014 15.7 26.4 6.2 2 1 2 4 4 2 0 Anti-sigma-K factor rskA CNDH2_C PF16858.5 CDI74299.1 - 0.015 15.2 26.7 0.24 11.2 2.5 3.1 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF2052 PF09747.9 CDI74299.1 - 0.027 14.6 22.9 0.78 9.8 4.7 3.3 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) DUF4770 PF15994.5 CDI74299.1 - 0.068 13.4 39.6 0.69 10.1 5.9 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4770) SART-1 PF03343.13 CDI74299.1 - 0.092 11.3 34.7 0.36 9.4 2.3 2.3 2 0 0 2 2 2 0 SART-1 family HNOBA PF07701.14 CDI74299.1 - 0.11 11.9 20.7 0.7 9.3 1.7 3.2 3 0 0 3 3 3 0 Heme NO binding associated DUF4471 PF14740.6 CDI74299.1 - 0.12 11.6 19.7 0.25 10.5 1.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4471) OATP PF03137.20 CDI74299.1 - 0.12 10.6 14.2 1.6 7.0 0.8 3.1 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Spt20 PF12090.8 CDI74299.1 - 0.21 11.2 99.4 1.3 8.6 25.4 3.6 3 0 0 3 3 3 0 Spt20 family EPL1 PF10513.9 CDI74299.1 - 0.28 11.5 31.2 1.7 9.0 7.0 3.4 3 0 0 3 3 3 0 Enhancer of polycomb-like eIF-3_zeta PF05091.12 CDI74299.1 - 0.34 9.8 44.7 0.36 9.8 10.6 3.1 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EOS1 PF12326.8 CDI74299.1 - 0.35 10.8 17.3 2.1 8.2 1.7 3.3 3 0 0 3 3 3 0 N-glycosylation protein Band_3_cyto PF07565.13 CDI74299.1 - 0.47 10.2 30.7 0.43 10.4 2.0 3.2 3 0 0 3 3 3 0 Band 3 cytoplasmic domain Serinc PF03348.15 CDI74299.1 - 0.82 8.5 17.9 2.4 7.0 3.3 3.2 3 0 0 3 3 3 0 Serine incorporator (Serinc) PRP1_N PF06424.12 CDI74299.1 - 0.85 10.0 26.3 3.2 8.2 4.2 3.5 3 0 0 3 3 3 0 PRP1 splicing factor, N-terminal RPA43_OB PF17875.1 CDI74299.1 - 0.88 10.2 23.4 6.7 7.4 0.7 3.6 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I FAM176 PF14851.6 CDI74299.1 - 0.99 9.1 20.7 3.2 7.4 4.3 3.4 3 0 0 3 3 3 0 FAM176 family CLN3 PF02487.17 CDI74299.1 - 0.99 8.4 20.7 1.4 7.9 0.9 3.2 3 0 0 3 3 3 0 CLN3 protein SID-1_RNA_chan PF13965.6 CDI74299.1 - 1.2 7.4 7.8 7.9 4.8 0.3 3.0 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 Folate_carrier PF01770.18 CDI74299.1 - 1.3 7.7 18.6 1.8 7.2 0.4 3.2 3 0 0 3 3 3 0 Reduced folate carrier BORG_CEP PF14957.6 CDI74299.1 - 1.4 10.1 21.2 1.8 9.8 2.5 3.7 4 0 0 4 4 3 0 Cdc42 effector ART-PolyVal PF18760.1 CDI74299.1 - 2.2 9.3 14.9 4.7 8.2 3.2 3.3 3 0 0 3 3 3 0 ADP-Ribosyltransferase in polyvalent proteins SKA1 PF07160.12 CDI74299.1 - 2.4 8.0 29.2 3.9 7.3 3.7 3.3 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 U1snRNP70_N PF12220.8 CDI74299.1 - 2.8 8.7 30.1 2.8 8.6 5.0 3.4 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal WASH-7_C PF14746.6 CDI74299.1 - 3.4 7.3 36.5 0.092 12.4 5.6 3.2 3 0 0 3 3 3 0 WASH complex subunit 7, C-terminal FAM60A PF15396.6 CDI74299.1 - 4.9 7.1 24.1 7.7 6.5 1.3 3.3 3 0 0 3 3 3 0 Protein Family FAM60A CSG2 PF16965.5 CDI74299.1 - 5 6.0 14.2 3.9 6.3 0.3 3.1 3 0 0 3 3 3 0 Ceramide synthase regulator Spore_YhcN_YlaJ PF09580.10 CDI74299.1 - 5.1 7.2 24.0 0.99 9.5 0.1 3.2 3 0 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Eapp_C PF10238.9 CDI74299.1 - 5.3 7.1 37.2 0.33 11.0 1.2 3.6 3 1 0 3 3 3 0 E2F-associated phosphoprotein ATAD4 PF15321.6 CDI74299.1 - 6 8.3 22.3 18 6.7 3.8 3.7 3 0 0 3 3 3 0 ATPase family AAA domain containing 4 EIIBC-GUT_N PF03612.14 CDI74299.1 - 8.5 6.1 31.5 3 7.6 6.7 3.5 3 0 0 3 3 3 0 Sorbitol phosphotransferase enzyme II N-terminus PIP5K PF01504.18 CDI74299.1 - 8.6 5.5 26.2 1.9 7.6 2.1 3.1 3 0 0 3 3 3 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF5523 PF17661.1 CDI74299.1 - 8.7 6.0 33.4 0.14 11.8 3.5 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5523) CTU2 PF10288.9 CDI74299.1 - 9 6.6 34.3 4 7.7 5.8 3.9 3 0 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 TMEM89 PF15098.6 CDI74300.1 - 0.025 14.8 1.6 0.028 14.6 1.6 1.2 1 0 0 1 1 1 0 TMEM89 protein family Flagellin_N PF00669.20 CDI74300.1 - 0.031 14.4 10.2 0.035 14.2 10.2 1.1 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region SUIM_assoc PF16619.5 CDI74300.1 - 0.05 13.7 6.2 0.068 13.2 6.2 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 SUIM_assoc PF16619.5 CDI74301.1 - 0.025 14.6 0.5 0.025 14.6 0.5 7.3 5 2 0 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 Herpes_UL52 PF03121.15 CDI74302.1 - 0.00034 20.5 0.0 0.00045 20.1 0.0 1.2 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase Nop14 PF04147.12 CDI74302.1 - 2.2 6.4 4.8 2.3 6.3 4.8 1.1 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.11 CDI74302.1 - 8.4 5.9 5.5 14 5.2 5.5 1.3 1 0 0 1 1 1 0 PPP4R2 Apt1 PF10351.9 CDI74303.1 - 0.00051 19.0 11.1 0.00051 19.0 11.1 3.2 3 0 0 3 3 3 3 Golgi-body localisation protein domain SDA1 PF05285.12 CDI74303.1 - 0.013 14.9 0.4 0.013 14.9 0.4 3.8 3 1 0 4 4 4 0 SDA1 BtrH_N PF14399.6 CDI74303.1 - 0.05 13.9 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 Butirosin biosynthesis protein H, N-terminal eIF-3_zeta PF05091.12 CDI74304.1 - 0.031 13.2 28.4 0.033 13.2 28.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PNISR PF15996.5 CDI74304.1 - 0.036 14.3 27.4 0.048 13.9 27.4 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Presenilin PF01080.17 CDI74304.1 - 0.045 12.5 27.8 0.044 12.5 27.8 1.1 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 CDI74304.1 - 0.057 12.9 24.6 0.068 12.6 24.6 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Band_3_cyto PF07565.13 CDI74304.1 - 0.059 13.2 21.7 0.073 12.9 21.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain NPR3 PF03666.13 CDI74304.1 - 0.12 11.2 23.0 0.14 10.9 23.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Spem1 PF15670.5 CDI74304.1 - 0.12 12.0 18.9 0.14 11.7 18.9 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 CDC45 PF02724.14 CDI74304.1 - 0.14 10.4 21.7 0.15 10.3 21.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Pox_Ag35 PF03286.14 CDI74304.1 - 0.15 11.8 15.9 0.19 11.5 15.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF4746 PF15928.5 CDI74304.1 - 0.17 11.3 16.6 0.19 11.1 16.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Connexin PF00029.19 CDI74304.1 - 0.19 11.4 17.3 0.22 11.2 17.3 1.3 1 0 0 1 1 1 0 Connexin Tim54 PF11711.8 CDI74304.1 - 0.23 10.2 20.3 0.27 10.0 20.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CLN3 PF02487.17 CDI74304.1 - 0.27 10.2 18.2 0.31 10.0 18.2 1.2 1 0 0 1 1 1 0 CLN3 protein DUF2828 PF11443.8 CDI74304.1 - 0.31 9.1 24.2 0.32 9.0 24.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Sin_N PF04801.13 CDI74304.1 - 0.36 10.0 41.0 0.43 9.7 41.0 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region DUF913 PF06025.12 CDI74304.1 - 0.49 9.3 15.1 0.52 9.2 15.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF789 PF05623.12 CDI74304.1 - 0.52 9.9 20.2 0.62 9.7 20.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF789) Apt1 PF10351.9 CDI74304.1 - 0.54 9.1 17.5 0.63 8.8 17.5 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4175 PF13779.6 CDI74304.1 - 0.55 8.1 57.1 0.7 7.7 57.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) FAM76 PF16046.5 CDI74304.1 - 0.58 9.5 28.2 0.81 9.0 28.2 1.2 1 0 0 1 1 1 0 FAM76 protein Velvet PF11754.8 CDI74304.1 - 0.66 9.9 21.4 0.75 9.7 21.4 1.3 1 0 0 1 1 1 0 Velvet factor FTZ PF03867.14 CDI74304.1 - 0.79 9.2 23.3 1 8.9 23.3 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region SpoIIIAH PF12685.7 CDI74304.1 - 0.9 9.3 32.9 1.2 8.9 32.9 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein SMN PF06003.12 CDI74304.1 - 1 8.6 9.4 1.2 8.3 9.4 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DUF2126 PF09899.9 CDI74304.1 - 1 7.3 16.4 1.1 7.3 16.4 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF4045 PF13254.6 CDI74304.1 - 1.1 8.9 26.5 1.2 8.7 26.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) MMM1 PF10296.9 CDI74304.1 - 1.2 8.2 13.6 1.3 7.9 13.6 1.3 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 SLC12 PF03522.15 CDI74304.1 - 1.3 8.0 28.9 1.4 7.9 28.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF908 PF06012.12 CDI74304.1 - 1.3 8.4 21.2 1.5 8.1 21.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SAPS PF04499.15 CDI74304.1 - 1.4 7.6 19.2 1.6 7.4 19.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Otopetrin PF03189.13 CDI74304.1 - 1.4 7.6 14.8 1.4 7.7 14.8 1.1 1 0 0 1 1 1 0 Otopetrin DUF1764 PF08576.10 CDI74304.1 - 1.5 9.8 26.3 0.27 12.2 22.3 1.8 2 0 0 2 2 1 0 Eukaryotic protein of unknown function (DUF1764) TT_ORF1 PF02956.14 CDI74304.1 - 1.8 7.1 20.8 1.8 7.2 20.8 1.1 1 0 0 1 1 1 0 TT viral orf 1 Neur_chan_memb PF02932.16 CDI74304.1 - 1.8 8.5 22.7 2.2 8.3 22.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1387 PF07139.11 CDI74304.1 - 2 8.1 25.5 2.4 7.8 25.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Membralin PF09746.9 CDI74304.1 - 2.1 7.3 20.0 2.2 7.2 20.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein SOBP PF15279.6 CDI74304.1 - 2.5 8.7 27.0 2.7 8.5 27.0 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Lin-8 PF03353.15 CDI74304.1 - 3 7.3 31.1 3.4 7.1 31.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2151 PF10221.9 CDI74304.1 - 3 6.3 17.0 3 6.3 17.0 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator MDM10 PF12519.8 CDI74304.1 - 3.1 6.6 23.7 3.3 6.5 23.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SARAF PF06682.12 CDI74304.1 - 3.1 7.4 20.8 3.8 7.1 20.8 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2370 PF10176.9 CDI74304.1 - 3.1 7.4 13.2 3.4 7.3 13.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) SRP-alpha_N PF04086.13 CDI74304.1 - 3.3 7.5 26.7 4.1 7.3 26.7 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal WTX PF09422.10 CDI74304.1 - 4 6.4 21.3 4.7 6.2 21.3 1.1 1 0 0 1 1 1 0 WTX protein Hid1 PF12722.7 CDI74304.1 - 4.7 5.2 25.8 5 5.1 25.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Hamartin PF04388.12 CDI74304.1 - 5 5.7 24.9 5.1 5.6 24.9 1.1 1 0 0 1 1 1 0 Hamartin protein Zip PF02535.22 CDI74304.1 - 5.4 6.1 18.2 6.2 5.9 18.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SID-1_RNA_chan PF13965.6 CDI74304.1 - 5.9 5.2 13.7 6 5.1 13.7 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Paramyxo_ncap PF00973.19 CDI74304.1 - 6 5.7 19.2 6.1 5.6 19.2 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Plasmodium_Vir PF05795.11 CDI74304.1 - 6.1 6.2 14.7 6.6 6.0 14.7 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein GREB1 PF15782.5 CDI74304.1 - 6.2 3.8 25.9 6.3 3.8 25.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Afi1 PF07792.12 CDI74304.1 - 6.4 7.3 26.3 11 6.5 26.3 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking BAF1_ABF1 PF04684.13 CDI74304.1 - 6.6 5.7 29.4 7.6 5.5 29.4 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Cellulose_synt PF03552.14 CDI74304.1 - 6.6 5.1 12.0 7 5.0 12.0 1.1 1 0 0 1 1 1 0 Cellulose synthase Rrn6 PF10214.9 CDI74304.1 - 7.2 5.0 29.8 7 5.0 29.8 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Glyco_transf_41 PF13844.6 CDI74304.1 - 7.9 4.8 13.6 8.4 4.7 13.6 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 41 TORC_M PF12885.7 CDI74304.1 - 8.4 6.3 16.4 10 6.0 16.4 1.3 1 0 0 1 1 1 0 Transducer of regulated CREB activity middle domain PIG-S PF10510.9 CDI74304.1 - 9.8 4.9 27.2 12 4.5 27.2 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Ureide_permease PF07168.11 CDI74304.1 - 9.8 4.8 14.3 15 4.2 14.3 1.3 1 0 0 1 1 1 0 Ureide permease DUF966 PF06136.13 CDI74304.1 - 9.9 5.8 21.7 12 5.5 21.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) SMC_N PF02463.19 CDI74305.1 - 1.2e-24 87.0 0.0 1.2e-24 87.0 0.0 2.6 3 2 0 3 3 3 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CDI74305.1 - 1.9e-16 60.4 0.0 8.6e-16 58.3 0.0 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 CDI74305.1 - 6.6e-07 29.4 2.2 6.6e-07 29.4 2.2 3.9 2 2 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 CDI74305.1 - 0.00066 20.2 36.2 0.00066 20.2 36.2 6.5 2 2 1 3 3 3 1 AAA domain AAA_21 PF13304.6 CDI74305.1 - 0.0014 18.5 1.9 0.0025 17.7 0.1 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDI74305.1 - 0.0017 18.0 0.2 0.0054 16.5 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain APG6_N PF17675.1 CDI74305.1 - 0.0078 16.7 18.9 0.0078 16.7 18.9 8.5 2 2 6 8 8 8 1 Apg6 coiled-coil region DUF4602 PF15375.6 CDI74307.1 - 0.0011 19.2 6.6 0.0011 19.2 6.6 4.4 4 1 1 5 5 5 1 Domain of unknown function (DUF4602) Sec1 PF00995.23 CDI74307.1 - 0.54 9.4 2.7 1.2 8.3 2.7 1.5 1 0 0 1 1 1 0 Sec1 family EAP30 PF04157.16 CDI74308.1 - 0.013 14.8 5.5 0.13 11.5 0.2 2.9 2 0 0 2 2 2 0 EAP30/Vps36 family PRA-PH PF01503.17 CDI74308.1 - 0.3 11.5 1.3 1.8 9.1 0.0 2.9 4 0 0 4 4 4 0 Phosphoribosyl-ATP pyrophosphohydrolase DUF29 PF01724.16 CDI74308.1 - 1.3 9.2 4.8 14 5.9 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF29 TALPID3 PF15324.6 CDI74308.1 - 4.1 5.0 10.0 8.8 3.8 10.0 1.5 1 0 0 1 1 1 0 Hedgehog signalling target C2 PF00168.30 CDI74310.1 - 1.7e-13 50.7 0.0 4.4e-13 49.4 0.0 1.7 2 0 0 2 2 2 1 C2 domain Ferlin_C PF16165.5 CDI74310.1 - 0.0013 18.7 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 Ferlin C-terminus SF3b1 PF08920.10 CDI74311.1 - 6.6e-18 65.3 3.4 2.4e-17 63.5 3.4 1.9 1 1 0 1 1 1 1 Splicing factor 3B subunit 1 HEAT PF02985.22 CDI74311.1 - 1.7e-09 37.1 6.5 0.91 10.0 0.1 8.4 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 CDI74311.1 - 2.3e-08 34.3 6.0 0.13 12.7 0.1 6.7 4 2 4 8 8 8 4 HEAT repeats UME PF08064.13 CDI74311.1 - 3e-06 27.1 0.8 7 6.6 0.0 5.6 5 1 1 6 6 6 2 UME (NUC010) domain HEAT_EZ PF13513.6 CDI74311.1 - 5.2e-06 26.8 10.0 0.2 12.2 0.0 6.6 7 1 0 7 7 7 2 HEAT-like repeat Adaptin_N PF01602.20 CDI74311.1 - 3.2e-05 22.7 3.3 0.13 10.8 0.0 4.0 4 1 1 5 5 5 3 Adaptin N terminal region NUC173 PF08161.12 CDI74311.1 - 0.0025 17.5 0.0 2.3 7.8 0.0 4.4 3 1 1 4 4 4 1 NUC173 domain CLASP_N PF12348.8 CDI74311.1 - 0.0093 15.6 0.1 0.73 9.4 0.0 2.8 2 0 0 2 2 2 1 CLASP N terminal Arm PF00514.23 CDI74311.1 - 0.12 12.4 6.4 50 4.1 0.0 5.2 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat RskA PF10099.9 CDI74312.1 - 0.00016 22.0 4.6 0.00016 22.0 4.6 6.5 2 1 3 5 5 5 1 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI74312.1 - 0.0046 16.0 13.4 0.0046 16.0 13.4 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) DUF2681 PF10883.8 CDI74312.1 - 0.97 9.9 15.6 0.35 11.3 6.9 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) EF-hand_1 PF00036.32 CDI74314.1 - 1.9e-29 99.0 3.7 2.7e-07 29.6 0.3 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDI74314.1 - 1e-28 99.5 1.1 1e-15 57.9 0.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI74314.1 - 1.9e-25 86.6 3.4 8.1e-08 31.6 0.0 4.5 4 1 1 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 CDI74314.1 - 9.4e-24 83.0 5.9 3e-11 43.0 0.1 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 CDI74314.1 - 7.9e-14 51.7 0.0 1.7e-07 31.5 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 CDI74314.1 - 1.2e-09 37.3 11.1 4.2e-05 22.9 0.4 4.8 4 1 1 5 5 5 3 EF hand EF-hand_4 PF12763.7 CDI74314.1 - 3.3e-05 23.8 0.5 0.012 15.5 0.1 2.7 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 CDI74314.1 - 0.00036 20.8 0.1 1.3 9.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain TerB PF05099.13 CDI74314.1 - 0.0054 16.7 0.1 1.3 8.9 0.0 2.9 2 1 0 2 2 2 1 Tellurite resistance protein TerB DUF3008 PF11450.8 CDI74314.1 - 0.013 15.6 2.1 0.015 15.4 0.4 1.9 2 0 0 2 2 2 0 Protein of unknwon function (DUF3008) SPARC_Ca_bdg PF10591.9 CDI74314.1 - 0.013 15.8 0.0 1.4 9.2 0.0 2.2 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 CDI74314.1 - 0.038 13.9 0.0 20 5.1 0.0 2.8 2 1 1 3 3 3 0 Caleosin related protein B5 PF03484.15 CDI74314.1 - 0.11 12.8 0.7 11 6.4 0.0 2.8 3 1 0 3 3 3 0 tRNA synthetase B5 domain Clathrin PF00637.20 CDI74315.1 - 1.2e-06 28.4 4.4 1e-05 25.4 0.5 3.4 2 1 0 2 2 2 1 Region in Clathrin and VPS Pex14_N PF04695.13 CDI74315.1 - 1.1e-05 26.2 27.8 1.1e-05 26.2 27.8 5.1 4 1 1 5 5 4 1 Peroxisomal membrane anchor protein (Pex14p) conserved region CDC45 PF02724.14 CDI74315.1 - 2.3e-05 22.9 8.8 2.3e-05 22.9 8.8 1.8 2 0 0 2 2 2 1 CDC45-like protein Band_3_cyto PF07565.13 CDI74315.1 - 2.6e-05 24.2 11.1 2.6e-05 24.2 11.1 3.5 2 1 1 3 3 3 1 Band 3 cytoplasmic domain LAP1C PF05609.12 CDI74315.1 - 0.0035 16.5 22.3 0.0035 16.5 22.3 3.4 4 0 0 4 4 4 1 Lamina-associated polypeptide 1C (LAP1C) eIF-3_zeta PF05091.12 CDI74315.1 - 0.0055 15.7 35.4 0.0055 15.7 35.4 2.3 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Herpes_UL74 PF07982.12 CDI74315.1 - 0.11 11.4 0.5 0.25 10.3 0.5 1.5 1 0 0 1 1 1 0 Herpes UL74 glycoproteins Suf PF05843.14 CDI74315.1 - 0.13 12.3 51.6 0.13 12.2 32.3 3.2 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) Pkinase_fungal PF17667.1 CDI74315.1 - 0.18 10.6 17.8 0.03 13.1 9.1 2.7 3 0 0 3 3 3 0 Fungal protein kinase Mem_trans PF03547.18 CDI74315.1 - 0.31 9.4 3.9 0.6 8.4 3.9 1.4 1 0 0 1 1 1 0 Membrane transport protein RR_TM4-6 PF06459.12 CDI74315.1 - 0.7 9.7 42.3 0.099 12.5 35.3 2.8 2 1 1 3 3 3 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI74315.1 - 1.1 7.5 67.3 0.012 13.9 50.3 2.3 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Claudin_2 PF13903.6 CDI74315.1 - 3.1 7.5 11.3 21 4.8 11.3 2.6 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF1905 PF08922.11 CDI74316.1 - 0.12 12.5 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1905) RIFIN PF02009.16 CDI74318.1 - 9.7 6.0 6.3 0.66 9.8 0.9 1.7 2 0 0 2 2 2 0 Rifin ThiD2 PF17792.1 CDI74319.1 - 0.11 13.0 0.0 0.12 12.9 0.0 1.2 1 0 0 1 1 1 0 ThiD2 family ADH_zinc_N PF00107.26 CDI74320.1 - 9.3e-25 87.1 0.1 1.4e-24 86.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDI74320.1 - 3.2e-14 52.7 3.0 3.2e-14 52.7 3.0 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 CDI74320.1 - 7.7e-05 22.3 0.1 0.00019 21.0 0.1 1.6 1 1 1 2 2 2 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CDI74320.1 - 0.001 18.4 0.5 0.0015 17.9 0.5 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 CDI74320.1 - 0.0017 18.0 0.2 0.0026 17.4 0.2 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 CDI74320.1 - 0.18 11.1 0.7 0.43 9.9 0.1 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PuR_N PF09182.10 CDI74321.1 - 0.12 12.3 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal Pkinase PF00069.25 CDI74324.1 - 8e-69 231.9 0.0 9.6e-69 231.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI74324.1 - 1.9e-34 119.2 0.0 2.3e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI74324.1 - 3.5e-06 26.5 0.0 1.8e-05 24.2 0.0 2.0 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 CDI74324.1 - 7e-06 25.5 0.1 1.3e-05 24.6 0.1 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDI74324.1 - 0.00051 20.0 0.0 0.55 10.1 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Cytokin-bind PF09265.10 CDI74324.1 - 0.064 12.6 0.0 0.2 11.0 0.0 1.8 3 0 0 3 3 3 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding RRM_1 PF00076.22 CDI74325.1 - 2.1e-18 65.9 0.1 3.3e-18 65.2 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDI74325.1 - 0.01 15.8 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif FlxA PF14282.6 CDI74327.1 - 0.0048 16.9 33.8 0.0048 16.9 33.8 10.6 8 1 2 10 10 10 1 FlxA-like protein PAT1 PF09770.9 CDI74328.1 - 0.026 12.8 35.9 0.028 12.7 35.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Gti1_Pac2 PF09729.9 CDI74328.1 - 1.9 8.5 15.0 3.8 7.5 15.0 1.6 1 0 0 1 1 1 0 Gti1/Pac2 family eIF-3_zeta PF05091.12 CDI74328.1 - 5.1 6.0 26.6 6.3 5.6 26.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SRRM_C PF15230.6 CDI74330.1 - 0.0031 18.1 4.2 0.0031 18.1 4.2 2.4 2 0 0 2 2 2 1 Serine/arginine repetitive matrix protein C-terminus RskA PF10099.9 CDI74330.1 - 1.5 9.1 27.9 4.5 7.5 27.9 1.7 1 1 0 1 1 1 0 Anti-sigma-K factor rskA PIP5K PF01504.18 CDI74330.1 - 2.3 7.4 8.2 3.4 6.8 8.2 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase STAC2_u1 PF16664.5 CDI74330.1 - 5.9 7.4 15.3 0.85 10.1 6.5 2.1 1 1 1 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 BAT2_N PF07001.11 CDI74330.1 - 7.9 6.9 24.7 11 6.4 24.7 1.2 1 0 0 1 1 1 0 BAT2 N-terminus Phage_integrase PF00589.22 CDI74331.1 - 1.3e-17 64.2 0.0 1.9e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 Phage integrase family DZR PF12773.7 CDI74331.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Double zinc ribbon DHC_N2 PF08393.13 CDI74335.1 - 1.2e-15 57.6 2.6 2e-15 56.8 0.1 2.2 2 1 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 Baculo_PEP_C PF04513.12 CDI74335.1 - 0.0015 18.6 1.8 0.014 15.5 0.1 3.0 2 1 0 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus COG2 PF06148.11 CDI74335.1 - 0.011 15.9 1.6 0.27 11.3 0.4 3.0 1 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Nup54_57_C PF18570.1 CDI74335.1 - 0.028 14.0 1.2 0.11 12.2 1.2 2.0 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain ORF11CD3 PF10549.9 CDI74335.1 - 0.029 14.5 0.9 0.1 12.7 0.2 2.3 2 0 0 2 2 2 0 ORF11CD3 domain DUF4200 PF13863.6 CDI74335.1 - 0.074 13.4 3.6 0.56 10.6 1.6 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) RecR PF02132.15 CDI74335.1 - 0.11 12.1 0.1 0.36 10.4 0.1 1.9 1 0 0 1 1 1 0 RecR protein HisKA_3 PF07730.13 CDI74335.1 - 0.2 12.2 1.2 1.9 9.1 0.1 3.1 3 1 0 3 3 3 0 Histidine kinase Laminin_II PF06009.12 CDI74335.1 - 0.25 11.4 1.7 8.1 6.5 0.1 3.2 2 1 2 4 4 4 0 Laminin Domain II NPV_P10 PF05531.12 CDI74335.1 - 1.4 9.5 6.7 0.53 10.8 0.6 3.2 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FAM60A PF15396.6 CDI74336.1 - 0.18 11.8 17.3 0.52 10.3 13.0 2.1 2 0 0 2 2 2 0 Protein Family FAM60A SAPS PF04499.15 CDI74336.1 - 0.45 9.2 14.3 0.68 8.7 14.3 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MMR1 PF08505.10 CDI74336.1 - 0.47 10.7 32.9 1.3 9.2 22.8 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Herpes_UL74 PF07982.12 CDI74336.1 - 1.6 7.6 3.2 3.2 6.6 3.2 1.5 1 0 0 1 1 1 0 Herpes UL74 glycoproteins Lactonase PF10282.9 CDI74336.1 - 7.6 5.7 17.3 2.3 7.4 14.7 1.4 1 1 0 1 1 1 0 Lactonase, 7-bladed beta-propeller DUF3109 PF11307.8 CDI74336.1 - 8.7 6.1 11.2 0.46 10.3 5.3 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3109) RskA PF10099.9 CDI74337.1 - 4.2e-05 23.9 8.5 0.004 17.5 0.0 2.1 1 1 1 2 2 2 1 Anti-sigma-K factor rskA DUF4435 PF14491.6 CDI74337.1 - 0.003 17.5 1.2 0.0045 16.9 1.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4435) Folate_carrier PF01770.18 CDI74337.1 - 0.0062 15.3 4.7 0.075 11.8 1.1 2.1 2 0 0 2 2 2 2 Reduced folate carrier GramPos_pilinD1 PF16555.5 CDI74337.1 - 0.016 15.3 6.2 0.48 10.6 1.1 2.3 2 1 0 2 2 2 0 Gram-positive pilin subunit D1, N-terminal domain DcuC PF03606.15 CDI74337.1 - 0.031 12.8 0.7 3.5 6.0 0.2 2.2 2 0 0 2 2 2 0 C4-dicarboxylate anaerobic carrier G0-G1_switch_2 PF15103.6 CDI74337.1 - 0.044 14.2 0.5 0.044 14.2 0.5 2.3 2 1 1 3 3 3 0 G0/G1 switch protein 2 Succ_CoA_lig PF13607.6 CDI74337.1 - 0.045 13.5 3.1 0.81 9.5 0.0 2.3 2 0 0 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain CemA PF03040.14 CDI74337.1 - 0.05 13.5 4.6 0.58 10.0 1.8 2.2 2 0 0 2 2 2 0 CemA family CLN3 PF02487.17 CDI74337.1 - 0.051 12.6 5.6 0.038 13.0 1.8 2.0 1 1 0 2 2 2 0 CLN3 protein OAD_gamma PF04277.13 CDI74337.1 - 0.055 14.1 9.2 0.065 13.8 0.2 2.8 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain DUF4149 PF13664.6 CDI74337.1 - 0.058 13.7 2.4 0.071 13.4 0.6 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4149) DUF4179 PF13786.6 CDI74337.1 - 0.078 13.5 5.3 4.7 7.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) DUF3899 PF13038.6 CDI74337.1 - 0.097 13.2 0.2 0.45 11.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) PigN PF04987.14 CDI74337.1 - 0.13 11.0 3.0 2.1 7.1 1.0 2.0 2 0 0 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) Gaa1 PF04114.14 CDI74337.1 - 0.31 10.0 6.6 3 6.8 0.2 2.1 1 1 1 2 2 2 0 Gaa1-like, GPI transamidase component COX16 PF14138.6 CDI74337.1 - 0.42 11.2 5.3 1.4 9.5 2.1 2.5 3 0 0 3 3 2 0 Cytochrome c oxidase assembly protein COX16 FAM176 PF14851.6 CDI74337.1 - 0.59 9.8 4.8 0.44 10.2 2.2 2.0 1 1 1 2 2 2 0 FAM176 family TMEM51 PF15345.6 CDI74337.1 - 0.71 9.7 9.3 1.2 8.9 6.6 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 DUF2232 PF09991.9 CDI74337.1 - 0.83 8.8 5.0 0.29 10.3 1.8 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) MFS_Mycoplasma PF07672.13 CDI74337.1 - 2 7.7 5.0 5.1 6.3 0.0 2.1 1 1 1 2 2 2 0 Mycoplasma MFS transporter DUF1682 PF07946.14 CDI74337.1 - 3.2 6.9 13.8 6.2 5.9 13.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF4179 PF13786.6 CDI74338.1 - 0.63 10.5 0.0 0.63 10.5 0.0 6.0 3 2 0 3 3 3 0 Domain of unknown function (DUF4179) Spt20 PF12090.8 CDI74338.1 - 2.4 7.7 9.2 0.07 12.7 2.3 1.9 2 0 0 2 2 2 0 Spt20 family Ni_hydr_CYTB PF01292.20 CDI74339.1 - 2.8 7.5 7.0 3.1 7.3 0.3 3.2 2 1 1 3 3 3 0 Prokaryotic cytochrome b561 SMYLE_N PF18615.1 CDI74339.1 - 4.5 6.7 62.3 4.9 6.6 29.8 2.3 1 1 1 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain RAP1 PF07218.11 CDI74340.1 - 0.019 13.3 23.7 0.024 13.0 23.7 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) TFIIA PF03153.13 CDI74340.1 - 0.52 10.3 76.1 0.72 9.8 76.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LAP1C PF05609.12 CDI74340.1 - 1.1 8.3 47.9 1.4 7.9 47.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Peptidase_S64 PF08192.11 CDI74340.1 - 1.6 7.1 47.9 1.9 6.8 47.9 1.0 1 0 0 1 1 1 0 Peptidase family S64 CDC27 PF09507.10 CDI74340.1 - 2.2 7.5 48.0 2.9 7.2 48.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 MAP70 PF07058.11 CDI74340.1 - 4.9 5.8 30.5 7 5.3 30.5 1.2 1 0 0 1 1 1 0 Microtubule-associated protein 70 DUF572 PF04502.13 CDI74340.1 - 8.7 5.9 44.9 13 5.3 44.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Peptidase_S49_N PF08496.10 CDI74342.1 - 0.0018 18.3 6.9 0.0019 18.3 6.9 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal DcuA_DcuB PF03605.14 CDI74342.1 - 0.0033 16.4 3.4 0.0037 16.2 3.4 1.0 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter Connexin PF00029.19 CDI74342.1 - 0.0044 16.8 0.7 0.0044 16.8 0.7 1.2 1 0 0 1 1 1 1 Connexin MSP1a PF11670.8 CDI74342.1 - 0.0047 16.3 3.4 0.0054 16.1 3.4 1.0 1 0 0 1 1 1 1 Major surface protein 1a (MSP1a) Bac_export_2 PF01312.19 CDI74342.1 - 0.011 15.0 7.9 0.013 14.8 7.9 1.0 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family FAM176 PF14851.6 CDI74342.1 - 0.013 15.1 1.3 0.013 15.1 1.3 1.2 1 0 0 1 1 1 0 FAM176 family DUF1980 PF09323.10 CDI74342.1 - 0.014 15.3 1.9 0.015 15.2 1.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) CLN3 PF02487.17 CDI74342.1 - 0.014 14.4 2.4 0.015 14.4 2.4 1.1 1 0 0 1 1 1 0 CLN3 protein PA26 PF04636.13 CDI74342.1 - 0.016 14.2 5.4 0.015 14.3 5.4 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) STAG PF08514.11 CDI74342.1 - 0.019 14.9 8.7 0.026 14.4 8.7 1.2 1 0 0 1 1 1 0 STAG domain Presenilin PF01080.17 CDI74342.1 - 0.02 13.7 6.1 0.02 13.7 6.1 1.2 1 0 0 1 1 1 0 Presenilin PEX11 PF05648.14 CDI74342.1 - 0.023 14.2 4.6 0.024 14.1 4.6 1.2 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) DUF2235 PF09994.9 CDI74342.1 - 0.026 13.9 2.8 0.031 13.6 2.8 1.1 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) SID-1_RNA_chan PF13965.6 CDI74342.1 - 0.03 12.8 0.7 0.028 12.8 0.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EOS1 PF12326.8 CDI74342.1 - 0.032 14.2 0.7 0.035 14.1 0.7 1.2 1 0 0 1 1 1 0 N-glycosylation protein Kei1 PF08552.11 CDI74342.1 - 0.033 14.1 5.5 0.043 13.7 5.5 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Eapp_C PF10238.9 CDI74342.1 - 0.033 14.3 7.6 0.039 14.0 7.6 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein CNDH2_N PF06278.11 CDI74342.1 - 0.033 14.4 8.2 0.042 14.1 8.2 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal eIF-3_zeta PF05091.12 CDI74342.1 - 0.038 13.0 10.5 0.037 13.0 10.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TMEM51 PF15345.6 CDI74342.1 - 0.053 13.4 7.8 0.052 13.4 7.8 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Ufd2P_core PF10408.9 CDI74342.1 - 0.074 11.7 13.6 0.081 11.5 13.6 1.0 1 0 0 1 1 1 0 Ubiquitin elongating factor core Serinc PF03348.15 CDI74342.1 - 0.083 11.8 2.5 0.091 11.7 2.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DcuC PF03606.15 CDI74342.1 - 0.085 11.3 1.9 0.1 11.0 1.9 1.0 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier SpoIIP PF07454.11 CDI74342.1 - 0.088 12.3 9.1 0.1 12.0 9.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Het-C PF07217.11 CDI74342.1 - 0.089 11.3 3.7 0.088 11.3 3.7 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DDHD PF02862.17 CDI74342.1 - 0.091 12.9 8.4 0.1 12.8 8.4 1.1 1 0 0 1 1 1 0 DDHD domain YABBY PF04690.13 CDI74342.1 - 0.092 13.3 3.0 0.092 13.3 3.0 1.2 1 0 0 1 1 1 0 YABBY protein Neur_chan_memb PF02932.16 CDI74342.1 - 0.11 12.6 3.0 0.11 12.6 3.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI74342.1 - 0.12 11.2 9.1 0.13 11.0 9.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter O-antigen_lig PF13425.6 CDI74342.1 - 0.12 11.1 0.2 0.12 11.1 0.2 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Peroxin-13_N PF04088.13 CDI74342.1 - 0.13 12.5 5.4 0.17 12.1 5.4 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region CSG2 PF16965.5 CDI74342.1 - 0.15 11.0 3.8 0.16 10.9 3.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator 7tm_7 PF08395.12 CDI74342.1 - 0.15 11.2 6.2 0.17 11.1 6.2 1.1 1 0 0 1 1 1 0 7tm Chemosensory receptor Baculo_PP31 PF05311.11 CDI74342.1 - 0.21 11.1 8.5 0.23 10.9 8.5 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Peptidase_S15 PF02129.18 CDI74342.1 - 0.21 11.2 11.3 0.25 10.9 11.3 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF4457 PF14652.6 CDI74342.1 - 0.29 10.4 6.2 0.3 10.3 6.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) PIP5K PF01504.18 CDI74342.1 - 0.29 10.3 6.8 0.35 10.0 6.8 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Orf78 PF06024.12 CDI74342.1 - 0.32 11.3 5.3 0.57 10.5 5.3 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Peptidase_U57 PF05582.12 CDI74342.1 - 0.35 10.1 6.0 0.34 10.1 6.0 1.1 1 0 0 1 1 1 0 YabG peptidase U57 TFIIA PF03153.13 CDI74342.1 - 0.46 10.4 29.6 0.53 10.2 29.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NEMP PF10225.9 CDI74342.1 - 0.5 10.0 4.1 0.61 9.7 4.1 1.2 1 0 0 1 1 1 0 NEMP family UPF0524 PF15823.5 CDI74342.1 - 0.61 9.4 6.2 0.77 9.1 6.2 1.1 1 0 0 1 1 1 0 UPF0524 of C3orf70 FapA PF03961.13 CDI74342.1 - 0.74 8.3 8.3 0.78 8.3 8.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A OATP PF03137.20 CDI74342.1 - 0.92 7.7 5.8 1.2 7.4 5.8 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Folliculin PF11704.8 CDI74342.1 - 1.1 9.1 9.0 1.3 8.9 9.0 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport EIIBC-GUT_N PF03612.14 CDI74342.1 - 1.1 8.9 11.8 1.5 8.5 11.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus RskA PF10099.9 CDI74342.1 - 1.3 9.2 21.2 5.7 7.2 21.2 1.8 1 1 0 1 1 1 0 Anti-sigma-K factor rskA TERB2 PF15101.6 CDI74342.1 - 1.4 8.9 15.8 1.8 8.6 15.8 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 WRNPLPNID PF15017.6 CDI74342.1 - 2 9.4 7.9 2.9 8.8 7.9 1.3 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box AIF_C PF14721.6 CDI74342.1 - 3.1 8.1 8.1 4.9 7.5 8.1 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Nucleoside_tran PF01733.18 CDI74342.1 - 3.2 7.1 6.2 2.9 7.2 5.8 1.3 1 1 0 1 1 1 0 Nucleoside transporter RED_N PF07808.13 CDI74342.1 - 4.2 6.9 17.3 5.5 6.5 17.3 1.2 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF2232 PF09991.9 CDI74342.1 - 4.3 6.4 9.8 6.6 5.8 9.8 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2232) FAM150 PF15129.6 CDI74342.1 - 4.8 7.4 12.9 6.4 7.0 12.9 1.1 1 0 0 1 1 1 0 FAM150 family Suf PF05843.14 CDI74342.1 - 5.1 7.0 15.4 6.3 6.7 15.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) ORC_WH_C PF18137.1 CDI74342.1 - 5.2 7.1 13.0 7.6 6.6 13.0 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Chromo PF00385.24 CDI74345.1 - 6.5e-11 42.0 0.0 1.2e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain fn3 PF00041.21 CDI74345.1 - 0.0047 17.2 0.0 0.0067 16.8 0.0 1.2 1 0 0 1 1 1 1 Fibronectin type III domain RskA PF10099.9 CDI74347.1 - 0.45 10.8 111.0 0.24 11.7 17.2 7.5 2 2 4 6 6 6 0 Anti-sigma-K factor rskA Coilin_N PF15862.5 CDI74347.1 - 9.4 6.0 0.0 9.4 6.0 0.0 6.3 4 2 1 5 5 5 0 Coilin N-terminus Peptidase_S49_N PF08496.10 CDI74348.1 - 0.0015 18.6 8.8 0.0018 18.3 8.8 1.3 1 1 0 1 1 1 1 Peptidase family S49 N-terminal DUF2722 PF10846.8 CDI74348.1 - 0.0046 16.0 10.2 0.0054 15.7 10.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Med15 PF09606.10 CDI74348.1 - 0.0058 15.4 14.3 0.0069 15.1 14.3 1.2 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4446 PF14584.6 CDI74348.1 - 0.0069 16.4 1.9 0.0097 15.9 1.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4446) SID-1_RNA_chan PF13965.6 CDI74348.1 - 0.008 14.7 2.5 0.0097 14.4 2.5 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Spt20 PF12090.8 CDI74348.1 - 0.01 15.4 17.7 0.012 15.2 17.7 1.1 1 0 0 1 1 1 0 Spt20 family DUF1980 PF09323.10 CDI74348.1 - 0.015 15.2 0.5 0.02 14.8 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) MMM1 PF10296.9 CDI74348.1 - 0.017 14.2 0.6 0.021 13.9 0.6 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 TFIIA PF03153.13 CDI74348.1 - 0.048 13.7 22.3 0.057 13.4 22.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EMC3_TMCO1 PF01956.16 CDI74348.1 - 0.06 13.1 0.9 0.084 12.6 0.9 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like V_ATPase_I PF01496.19 CDI74348.1 - 0.069 11.1 2.8 0.083 10.8 2.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PIG-S PF10510.9 CDI74348.1 - 0.077 11.8 8.2 0.093 11.5 8.2 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein IgaA PF07095.11 CDI74348.1 - 0.13 10.2 3.3 0.15 10.0 3.3 1.0 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA NEMP PF10225.9 CDI74348.1 - 0.14 11.8 0.7 0.19 11.4 0.7 1.2 1 0 0 1 1 1 0 NEMP family Rpp20 PF12328.8 CDI74348.1 - 0.14 12.1 6.9 0.21 11.5 6.9 1.4 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P Roughex PF06020.11 CDI74348.1 - 0.16 11.0 10.4 0.18 10.9 10.4 1.1 1 0 0 1 1 1 0 Drosophila roughex protein RAB3GAP2_N PF14655.6 CDI74348.1 - 0.2 10.9 7.4 0.23 10.7 7.4 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Serinc PF03348.15 CDI74348.1 - 0.3 10.0 4.7 0.34 9.8 4.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ctr PF04145.15 CDI74348.1 - 0.33 11.6 5.4 0.43 11.2 5.4 1.3 1 1 0 1 1 1 0 Ctr copper transporter family DUF4834 PF16118.5 CDI74348.1 - 0.45 11.5 9.9 0.96 10.5 9.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Mcm10 PF09332.11 CDI74348.1 - 0.46 9.8 11.1 0.54 9.6 11.1 1.1 1 0 0 1 1 1 0 Mcm10 replication factor CPSF100_C PF13299.6 CDI74348.1 - 0.5 10.5 9.0 0.65 10.2 9.0 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 CDI74348.1 - 0.72 8.8 6.0 0.84 8.5 6.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) EPL1 PF10513.9 CDI74348.1 - 0.99 9.8 6.9 1.2 9.5 6.9 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like TRAP_alpha PF03896.16 CDI74348.1 - 1.1 8.4 6.7 1.6 7.9 6.3 1.4 1 1 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Macoilin PF09726.9 CDI74348.1 - 1.5 7.3 8.5 1.6 7.2 8.5 1.2 1 0 0 1 1 1 0 Macoilin family DUF2052 PF09747.9 CDI74348.1 - 2.4 8.2 10.2 2.9 8.0 10.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Calc_CGRP_IAPP PF00214.19 CDI74348.1 - 2.5 8.5 7.8 4.1 7.8 7.6 1.7 1 1 0 1 1 1 0 Calcitonin / CGRP / IAPP family RR_TM4-6 PF06459.12 CDI74348.1 - 2.9 7.6 11.6 3.5 7.4 11.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GREB1 PF15782.5 CDI74348.1 - 4.2 4.4 9.2 4.2 4.3 9.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FUN14 PF04930.15 CDI74348.1 - 5 7.6 7.7 6.7 7.2 7.3 1.7 1 1 0 1 1 1 0 FUN14 family DUF5383 PF17355.2 CDI74348.1 - 6.1 7.2 9.8 1.5 9.2 2.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5383) SP_C-Propep PF08999.10 CDI74348.1 - 8.4 6.3 9.7 0.7 9.7 5.0 1.7 2 0 0 2 2 1 0 Surfactant protein C, N terminal propeptide Baculo_11_kDa PF06143.11 CDI74348.1 - 8.5 6.0 8.8 0.46 10.1 0.3 2.4 2 0 0 2 2 2 0 Baculovirus 11 kDa family TFIIA PF03153.13 CDI74349.1 - 0.011 15.8 188.7 0.035 14.1 40.2 3.6 2 1 1 3 3 3 0 Transcription factor IIA, alpha/beta subunit AAA PF00004.29 CDI74350.1 - 4.6e-52 175.9 0.1 3.5e-24 85.7 0.0 6.7 5 1 0 5 5 5 4 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI74350.1 - 8.3e-11 41.5 5.9 1.1e-06 28.3 0.2 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_5 PF07728.14 CDI74350.1 - 4.1e-09 36.6 1.7 0.005 16.8 0.0 4.1 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 CDI74350.1 - 9.3e-08 32.0 2.0 0.01 15.6 0.0 3.3 3 0 0 3 3 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 CDI74350.1 - 1.8e-07 31.5 0.1 0.042 14.2 0.0 3.1 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 CDI74350.1 - 1.1e-05 25.0 0.2 0.016 14.6 0.1 3.2 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 CDI74350.1 - 2.5e-05 24.0 2.0 0.0099 15.6 0.0 3.4 4 0 0 4 4 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 CDI74350.1 - 3.4e-05 23.9 0.8 0.5 10.4 0.0 4.4 3 2 0 3 3 3 1 AAA domain TIP49 PF06068.13 CDI74350.1 - 0.00011 21.5 5.0 0.11 11.7 0.0 3.0 3 0 0 3 3 2 2 TIP49 P-loop domain AAA_33 PF13671.6 CDI74350.1 - 0.00024 21.3 0.4 0.011 15.9 0.1 6.8 5 2 0 5 5 4 2 AAA domain AAA_22 PF13401.6 CDI74350.1 - 0.00024 21.4 0.0 0.019 15.2 0.0 4.9 4 1 0 4 4 3 2 AAA domain AAA_18 PF13238.6 CDI74350.1 - 0.00039 21.0 11.3 0.039 14.5 0.3 5.0 3 1 1 4 4 4 2 AAA domain AAA_16 PF13191.6 CDI74350.1 - 0.00051 20.5 1.2 0.00051 20.5 1.2 7.5 3 2 1 4 4 3 1 AAA ATPase domain TsaE PF02367.17 CDI74350.1 - 0.00071 19.6 0.0 0.87 9.6 0.0 3.4 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 CDI74350.1 - 0.0011 19.0 7.4 0.0034 17.3 0.0 3.2 3 0 0 3 3 2 1 Rad17 P-loop domain DUF755 PF05501.11 CDI74350.1 - 0.0025 18.1 17.6 0.0025 18.1 17.6 13.0 8 4 2 10 10 3 2 Domain of unknown function (DUF755) RskA PF10099.9 CDI74350.1 - 0.0053 17.1 16.4 0.0053 17.1 16.4 10.0 3 3 4 7 7 4 1 Anti-sigma-K factor rskA MPM1 PF17234.2 CDI74350.1 - 0.0089 16.3 12.1 0.0089 16.3 12.1 9.2 7 1 2 9 9 7 1 Mitochondrial peculiar membrane protein 1 AAA_7 PF12775.7 CDI74350.1 - 0.053 13.0 7.6 0.39 10.2 0.0 3.0 3 0 0 3 3 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 CDI74350.1 - 0.11 12.7 0.0 0.11 12.7 0.0 7.1 7 1 1 8 8 3 0 AAA domain AAA_24 PF13479.6 CDI74350.1 - 0.46 10.2 0.0 0.46 10.2 0.0 4.3 4 0 0 4 4 3 0 AAA domain AAA_17 PF13207.6 CDI74350.1 - 2.5 8.5 0.0 2.5 8.5 0.0 5.2 5 1 0 5 5 3 0 AAA domain Cytochrom_C_2 PF01322.20 CDI74351.1 - 2.6e-05 25.1 0.1 0.41 11.5 0.0 2.4 2 0 0 2 2 2 2 Cytochrome C' N6_N4_Mtase PF01555.18 CDI74353.1 - 0.066 12.9 0.0 0.066 12.9 0.0 4.3 3 2 0 3 3 3 0 DNA methylase EF-hand_1 PF00036.32 CDI74354.1 - 2.7e-06 26.5 1.4 3.1e-05 23.2 0.2 2.6 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.6 CDI74354.1 - 4e-06 26.1 1.3 1.6e-05 24.2 0.2 2.3 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 CDI74354.1 - 2.1e-05 24.1 1.2 0.00032 20.4 0.2 2.5 1 1 1 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 CDI74354.1 - 5.9e-05 23.4 0.2 9.1e-05 22.8 0.2 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 CDI74354.1 - 0.024 14.5 0.9 0.21 11.5 0.2 2.3 1 1 1 2 2 2 0 EF-hand domain pair E1-E2_ATPase PF00122.20 CDI74355.1 - 2.6e-05 23.8 0.0 2.6e-05 23.8 0.0 3.1 3 1 1 4 4 4 1 E1-E2 ATPase TFIIA PF03153.13 CDI74355.1 - 9.7e-05 22.5 6.9 9.7e-05 22.5 6.9 2.5 3 0 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI74355.1 - 0.0012 18.5 11.5 0.0012 18.5 11.5 1.8 2 0 0 2 2 2 1 Spt20 family Med3 PF11593.8 CDI74355.1 - 0.0014 17.9 12.3 0.0014 17.9 12.3 3.2 4 0 0 4 4 1 1 Mediator complex subunit 3 fungal Pex14_N PF04695.13 CDI74355.1 - 0.0022 18.7 9.1 0.0022 18.7 9.1 3.3 3 1 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DivIC PF04977.15 CDI74355.1 - 0.0041 16.8 7.3 0.012 15.4 7.3 1.8 1 0 0 1 1 1 1 Septum formation initiator DUF2722 PF10846.8 CDI74355.1 - 0.019 13.9 11.6 0.041 12.8 11.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2722) DUF2339 PF10101.9 CDI74355.1 - 0.024 13.3 36.4 0.036 12.7 36.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) Med15 PF09606.10 CDI74355.1 - 0.036 12.8 12.3 0.083 11.6 12.3 1.5 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.14 CDI74355.1 - 0.069 13.1 4.4 0.16 11.9 4.4 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RAB3GAP2_N PF14655.6 CDI74355.1 - 0.076 12.3 0.5 0.12 11.6 0.5 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DDHD PF02862.17 CDI74355.1 - 0.079 13.1 1.0 0.37 10.9 0.1 2.2 2 0 0 2 2 2 0 DDHD domain Presenilin PF01080.17 CDI74355.1 - 0.16 10.7 0.1 0.36 9.5 0.0 1.7 2 0 0 2 2 2 0 Presenilin eIF-3_zeta PF05091.12 CDI74355.1 - 0.21 10.5 2.4 0.3 10.0 2.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CPSF100_C PF13299.6 CDI74355.1 - 3.6 7.7 7.9 0.12 12.5 0.2 2.3 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Hydrolase PF00702.26 CDI74357.1 - 1.7e-05 25.2 0.5 0.00012 22.4 0.2 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase PIN_4 PF13638.6 CDI74357.1 - 0.012 15.9 0.6 0.012 15.9 0.6 2.5 2 0 0 2 2 2 0 PIN domain CAF1 PF04857.20 CDI74357.1 - 0.23 10.6 13.5 1.1 8.3 0.7 2.5 2 0 0 2 2 2 0 CAF1 family ribonuclease DUF2347 PF09804.9 CDI74357.1 - 5.5 6.5 10.6 54 3.2 0.1 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2347) ApbA PF02558.16 CDI74358.1 - 0.0018 17.9 0.0 0.0046 16.6 0.0 1.7 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA DUF508 PF04370.12 CDI74358.1 - 0.24 11.1 0.0 0.24 11.1 0.0 4.3 3 2 1 4 4 4 0 Domain of unknown function (DUF508) SAS-6_N PF16531.5 CDI74359.1 - 9.7e-13 48.5 0.0 9.7e-13 48.5 0.0 5.1 4 2 0 4 4 4 1 Centriolar protein SAS N-terminal Mito_carr PF00153.27 CDI74359.1 - 6.2 6.8 7.4 1.8 8.6 0.0 4.1 3 0 0 3 3 3 0 Mitochondrial carrier protein CDK2AP PF09806.9 CDI74360.1 - 0.0082 16.2 7.2 0.0082 16.2 7.2 11.3 5 3 8 13 13 13 2 Cyclin-dependent kinase 2-associated protein ABC_tran PF00005.27 CDI74362.1 - 1.1e-30 106.9 9.1 1.5e-28 100.0 5.9 2.9 2 1 0 2 2 1 1 ABC transporter ABC_membrane PF00664.23 CDI74362.1 - 8.1e-13 48.6 0.4 1.4e-12 47.9 0.4 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDI74362.1 - 2.5e-09 36.9 1.0 3.5e-07 29.9 1.7 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDI74362.1 - 4.4e-05 23.8 3.7 0.014 15.6 0.2 3.0 2 1 1 3 3 2 2 AAA domain G-alpha PF00503.20 CDI74362.1 - 0.00012 21.3 0.3 0.00019 20.7 0.3 1.3 1 0 0 1 1 1 1 G-protein alpha subunit EPL1 PF10513.9 CDI74362.1 - 0.0018 18.6 16.8 0.0076 16.6 10.8 2.2 2 0 0 2 2 2 1 Enhancer of polycomb-like AAA PF00004.29 CDI74362.1 - 0.0024 18.3 1.0 2.3 8.6 0.6 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CDI74362.1 - 0.0033 17.1 0.0 0.0078 15.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CDI74362.1 - 0.0035 17.0 0.2 0.9 9.1 0.1 2.6 2 0 0 2 2 2 1 AAA domain TFIIA PF03153.13 CDI74362.1 - 0.0035 17.4 59.7 0.0073 16.4 41.5 2.2 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Velvet PF11754.8 CDI74362.1 - 0.0039 17.2 8.9 0.0039 17.2 8.9 2.2 2 0 0 2 2 2 1 Velvet factor Pex14_N PF04695.13 CDI74362.1 - 0.0075 16.9 25.1 0.0075 16.9 25.1 3.3 2 1 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region SUIM_assoc PF16619.5 CDI74362.1 - 0.0099 15.9 3.0 0.0099 15.9 3.0 5.4 3 1 0 3 3 1 1 Unstructured region C-term to UIM in Ataxin3 AAA_21 PF13304.6 CDI74362.1 - 0.015 15.2 0.0 0.45 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF702 PF05142.12 CDI74362.1 - 0.02 15.3 14.9 0.02 15.3 14.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF702) AAA_5 PF07728.14 CDI74362.1 - 0.022 14.7 0.0 0.066 13.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) Suf PF05843.14 CDI74362.1 - 0.033 14.2 25.5 0.087 12.8 17.7 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) SpoIIP PF07454.11 CDI74362.1 - 0.083 12.3 20.1 0.025 14.0 15.4 2.0 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) RsgA_GTPase PF03193.16 CDI74362.1 - 0.093 12.6 0.0 0.093 12.6 0.0 2.5 2 0 0 2 2 1 0 RsgA GTPase AAA_14 PF13173.6 CDI74362.1 - 0.11 12.5 1.3 0.96 9.5 0.0 2.7 3 0 0 3 3 2 0 AAA domain Zip PF02535.22 CDI74362.1 - 0.12 11.6 4.4 0.035 13.3 1.5 1.6 2 0 0 2 2 2 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 CDI74362.1 - 0.24 11.4 16.3 0.32 11.0 11.7 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SAGA-Tad1 PF12767.7 CDI74362.1 - 0.26 11.0 15.6 0.38 10.5 10.6 2.2 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit TCP PF03634.13 CDI74362.1 - 0.29 11.7 21.3 1.4 9.5 14.7 2.4 2 0 0 2 2 2 0 TCP family transcription factor DUF572 PF04502.13 CDI74362.1 - 0.42 10.2 18.8 0.25 10.9 10.5 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) DUF4045 PF13254.6 CDI74362.1 - 0.43 10.2 24.4 0.12 12.0 12.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) Cellulose_synt PF03552.14 CDI74362.1 - 0.52 8.7 2.8 0.96 7.9 2.8 1.3 1 0 0 1 1 1 0 Cellulose synthase Band_3_cyto PF07565.13 CDI74362.1 - 0.71 9.6 19.9 0.31 10.8 13.9 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Pet20 PF08692.10 CDI74362.1 - 0.9 10.3 9.4 0.74 10.5 6.2 2.1 2 0 0 2 2 2 0 Mitochondrial protein Pet20 AAA_23 PF13476.6 CDI74362.1 - 1.1 9.7 30.1 2.2 8.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain ALMT PF11744.8 CDI74362.1 - 1.2 7.9 17.0 0.062 12.1 10.1 1.9 2 0 0 2 2 2 0 Aluminium activated malate transporter GREB1 PF15782.5 CDI74362.1 - 1.4 5.9 26.0 0.04 11.1 12.5 2.0 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer RIFIN PF02009.16 CDI74362.1 - 1.4 8.7 22.6 1.9 8.3 7.2 2.4 2 0 0 2 2 2 0 Rifin AAA_24 PF13479.6 CDI74362.1 - 1.5 8.5 0.0 1.5 8.5 0.0 3.3 3 1 1 4 4 2 0 AAA domain SLC12 PF03522.15 CDI74362.1 - 1.8 7.5 20.4 0.97 8.4 16.4 1.9 2 0 0 2 2 2 0 Solute carrier family 12 DUF3464 PF11947.8 CDI74362.1 - 1.9 8.2 19.2 0.71 9.6 13.7 2.5 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Tim54 PF11711.8 CDI74362.1 - 2.8 6.6 23.6 0.12 11.2 15.9 2.0 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF2072 PF09845.9 CDI74362.1 - 3 8.1 18.9 6.1 7.1 14.6 2.2 2 0 0 2 2 2 0 Zn-ribbon containing protein DUF4770 PF15994.5 CDI74362.1 - 3.1 8.0 23.7 0.53 10.5 17.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Hamartin PF04388.12 CDI74362.1 - 3.1 6.3 28.8 3 6.4 14.3 2.1 2 0 0 2 2 2 0 Hamartin protein CPSF100_C PF13299.6 CDI74362.1 - 3.2 7.9 24.5 0.25 11.5 12.4 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal CDC45 PF02724.14 CDI74362.1 - 3.3 5.9 17.5 0.93 7.7 14.2 1.6 2 0 0 2 2 2 0 CDC45-like protein Endostatin PF06482.11 CDI74362.1 - 3.4 7.1 23.4 0.73 9.2 16.2 2.1 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Gti1_Pac2 PF09729.9 CDI74362.1 - 3.5 7.7 18.9 1.1 9.3 14.1 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family Pkinase_fungal PF17667.1 CDI74362.1 - 3.5 6.3 10.2 0.2 10.4 3.1 2.0 2 0 0 2 2 2 0 Fungal protein kinase Med15 PF09606.10 CDI74362.1 - 3.6 6.2 53.8 0.49 9.0 37.2 3.0 3 0 0 3 3 3 0 ARC105 or Med15 subunit of Mediator complex non-fungal PTPRCAP PF15713.5 CDI74362.1 - 3.7 7.8 25.7 0.43 10.9 17.3 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DUF4820 PF16091.5 CDI74362.1 - 3.7 6.9 18.4 1.5 8.1 11.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) API5 PF05918.11 CDI74362.1 - 4 6.1 19.4 0.11 11.3 12.5 1.7 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) Presenilin PF01080.17 CDI74362.1 - 4 6.1 29.6 0.43 9.3 22.2 2.0 2 0 0 2 2 2 0 Presenilin DUF3807 PF12720.7 CDI74362.1 - 4.2 7.6 31.1 1.7 8.9 24.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) BORG_CEP PF14957.6 CDI74362.1 - 4.4 8.5 16.8 3.2 8.9 13.3 2.2 2 0 0 2 2 2 0 Cdc42 effector SAPS PF04499.15 CDI74362.1 - 4.6 5.9 15.3 0.54 9.0 10.5 1.7 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein eIF-3_zeta PF05091.12 CDI74362.1 - 5.1 5.9 31.7 1 8.2 26.4 1.9 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) LMBR1 PF04791.16 CDI74362.1 - 5.5 5.8 7.9 9.5 5.0 7.9 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein RR_TM4-6 PF06459.12 CDI74362.1 - 5.5 6.7 26.0 0.25 11.1 17.4 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 CDI74362.1 - 6.5 5.6 18.2 0.47 9.4 10.7 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) UPF0565 PF10561.9 CDI74362.1 - 6.9 5.8 9.3 0.18 10.9 1.5 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 T3SS_ATPase_C PF18269.1 CDI74364.1 - 0.074 12.9 0.3 0.16 11.8 0.3 1.5 1 0 0 1 1 1 0 T3SS EscN ATPase C-terminal domain GRIM-19 PF06212.12 CDI74364.1 - 0.11 12.5 2.9 0.13 12.2 2.9 1.3 1 0 0 1 1 1 0 GRIM-19 protein EMC3_TMCO1 PF01956.16 CDI74364.1 - 0.18 11.5 1.4 0.2 11.4 1.4 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Anillin_N PF16018.5 CDI74365.1 - 0.4 11.3 2.5 0.72 10.5 2.5 1.4 1 0 0 1 1 1 0 Anillin N-terminus SR-25 PF10500.9 CDI74373.1 - 0.001 18.7 25.3 0.0015 18.2 25.3 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein SPX PF03105.19 CDI74373.1 - 2 8.3 21.5 3.2 7.6 21.5 1.4 1 0 0 1 1 1 0 SPX domain SAGA-Tad1 PF12767.7 CDI74373.1 - 2.7 7.7 17.2 4.5 6.9 17.2 1.3 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit CDC45 PF02724.14 CDI74374.1 - 0.77 8.0 38.4 1.1 7.5 38.4 1.2 1 0 0 1 1 1 0 CDC45-like protein GET2 PF08690.10 CDI74375.1 - 8e-05 22.5 1.7 8e-05 22.5 1.7 3.7 3 1 0 3 3 3 1 GET complex subunit GET2 RskA PF10099.9 CDI74376.1 - 3.3e-05 24.2 40.6 0.025 14.9 12.2 4.2 2 1 2 4 4 4 3 Anti-sigma-K factor rskA WD40 PF00400.32 CDI74376.1 - 0.0021 18.8 0.7 0.83 10.6 0.0 3.1 2 1 0 2 2 2 1 WD domain, G-beta repeat Utp14 PF04615.13 CDI74376.1 - 0.013 14.1 32.9 0.032 12.8 33.0 1.6 1 1 0 1 1 1 0 Utp14 protein DUF4611 PF15387.6 CDI74376.1 - 0.016 15.4 5.7 0.15 12.3 0.4 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) U1snRNP70_N PF12220.8 CDI74376.1 - 0.037 14.7 9.8 1.6 9.4 1.5 2.7 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal eIF3_subunit PF08597.10 CDI74376.1 - 3.2 7.6 18.3 6.6 6.6 6.2 2.6 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Rpp20 PF12328.8 CDI74376.1 - 5.6 6.9 16.6 9.1 6.2 7.6 3.0 2 1 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Lin-8 PF03353.15 CDI74377.1 - 0.0015 18.2 35.0 0.0043 16.6 27.5 2.1 2 0 0 2 2 2 2 Ras-mediated vulval-induction antagonist PAT1 PF09770.9 CDI74377.1 - 0.012 14.0 41.2 0.014 13.7 41.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S49_N PF08496.10 CDI74377.1 - 0.074 13.1 13.1 0.18 11.9 13.1 1.7 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Hid1 PF12722.7 CDI74377.1 - 0.22 9.6 24.5 0.37 8.9 24.5 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Utp14 PF04615.13 CDI74377.1 - 0.44 9.1 30.0 0.61 8.6 30.0 1.1 1 0 0 1 1 1 0 Utp14 protein eIF-3_zeta PF05091.12 CDI74377.1 - 0.47 9.4 26.9 0.74 8.7 26.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) VIR_N PF15912.5 CDI74377.1 - 0.57 9.7 10.8 0.85 9.2 10.8 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Asp-B-Hydro_N PF05279.11 CDI74377.1 - 0.66 10.0 12.7 0.87 9.6 12.7 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DDRGK PF09756.9 CDI74377.1 - 2.3 7.8 27.8 3.9 7.0 27.8 1.3 1 0 0 1 1 1 0 DDRGK domain Nucleoside_tran PF01733.18 CDI74377.1 - 7.8 5.8 7.8 2.3 7.5 4.8 1.7 2 0 0 2 2 2 0 Nucleoside transporter Dicty_REP PF05086.12 CDI74377.1 - 9.6 4.0 16.7 14 3.5 16.7 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TFIIA PF03153.13 CDI74378.1 - 1 9.2 6.8 1.3 9.0 6.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4936 PF16290.5 CDI74378.1 - 6.1 7.6 8.6 1.8 9.3 5.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4936) WD40 PF00400.32 CDI74379.1 - 1.5e-22 79.4 8.3 0.0013 19.5 0.0 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI74379.1 - 4e-06 27.1 0.5 0.68 10.3 0.0 4.4 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain SUIM_assoc PF16619.5 CDI74379.1 - 0.006 16.6 3.7 0.006 16.6 3.7 12.5 4 2 4 8 8 8 1 Unstructured region C-term to UIM in Ataxin3 Trypan_PARP PF05887.11 CDI74380.1 - 0.038 14.0 15.4 0.046 13.7 15.4 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) GNAT_acetyltr_2 PF13718.6 CDI74380.1 - 3.1 7.1 6.6 3.4 7.0 6.6 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 U1snRNP70_N PF12220.8 CDI74380.1 - 3.5 8.3 12.3 4.7 7.9 12.3 1.4 1 1 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RR_TM4-6 PF06459.12 CDI74380.1 - 7.4 6.3 14.6 7.5 6.3 14.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MIF4G_like_2 PF09090.11 CDI74381.1 - 0.0048 16.4 1.3 0.0099 15.4 0.2 1.9 2 0 0 2 2 2 1 MIF4G like End3 PF12761.7 CDI74381.1 - 0.006 16.8 1.0 0.011 15.9 1.0 1.4 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 SR-25 PF10500.9 CDI74381.1 - 0.017 14.8 6.2 0.03 14.0 6.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MORN PF02493.20 CDI74384.1 - 8e-51 167.0 52.9 1.9e-06 27.4 2.8 10.2 10 0 0 10 10 10 10 MORN repeat Tudor_2 PF18104.1 CDI74384.1 - 0.03 14.0 1.2 63 3.4 0.0 5.0 6 0 0 6 6 6 0 Jumonji domain-containing protein 2A Tudor domain DUF3048_C PF17479.2 CDI74384.1 - 3.4 8.1 7.9 14 6.1 0.3 3.7 1 1 1 3 3 3 0 Protein of unknown function (DUF3048) C-terminal domain Ras PF00071.22 CDI74385.1 - 1.3e-56 190.7 0.0 1.6e-56 190.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI74385.1 - 9.1e-34 116.3 0.0 1.5e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI74385.1 - 1.4e-13 50.7 0.0 1.8e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDI74385.1 - 2.3e-07 30.4 0.0 2.8e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDI74385.1 - 0.00016 21.7 0.0 0.00033 20.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDI74385.1 - 0.0015 18.1 0.1 0.0045 16.6 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 CDI74385.1 - 0.0088 15.9 0.0 0.016 15.0 0.0 1.4 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein DUF2280 PF10045.9 CDI74385.1 - 0.015 15.6 0.1 0.024 14.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2280) RsgA_GTPase PF03193.16 CDI74385.1 - 0.057 13.3 0.1 2.7 7.9 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 CDI74385.1 - 0.069 13.5 0.0 0.099 13.0 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Pkinase_Tyr PF07714.17 CDI74386.1 - 7.3e-36 123.8 0.0 4.5e-14 52.3 0.0 4.6 3 2 0 4 4 4 3 Protein tyrosine kinase Pkinase PF00069.25 CDI74386.1 - 7.5e-34 117.3 1.0 6.5e-24 84.7 0.0 4.2 4 1 0 4 4 4 2 Protein kinase domain AAA PF00004.29 CDI74387.1 - 2.9e-17 63.3 0.7 1.1e-16 61.5 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CDI74387.1 - 4.5e-13 49.3 0.0 2.5e-11 43.6 0.0 2.4 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 CDI74387.1 - 5e-11 42.9 0.0 4.1e-10 39.9 0.0 2.4 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA_22 PF13401.6 CDI74387.1 - 3e-06 27.6 1.1 1.5e-05 25.3 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CDI74387.1 - 5.3e-06 26.4 1.1 7.1e-05 22.7 0.1 2.6 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDI74387.1 - 2.3e-05 24.9 2.4 0.00015 22.2 0.2 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 CDI74387.1 - 3e-05 24.1 0.0 6.4e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDI74387.1 - 5.1e-05 23.1 1.6 6.4e-05 22.8 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_assoc_2 PF16193.5 CDI74387.1 - 7.5e-05 23.0 0.0 0.00021 21.6 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain Rad17 PF03215.15 CDI74387.1 - 0.00016 21.7 0.1 0.00077 19.4 0.0 2.1 2 1 0 2 2 2 1 Rad17 P-loop domain RuvB_N PF05496.12 CDI74387.1 - 0.0008 19.2 0.0 0.003 17.3 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain ResIII PF04851.15 CDI74387.1 - 0.0016 18.5 0.0 0.018 15.0 0.0 2.2 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_5 PF07728.14 CDI74387.1 - 0.0031 17.5 0.2 0.022 14.7 0.1 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CDI74387.1 - 0.004 16.9 0.0 0.0093 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CDI74387.1 - 0.0075 15.7 0.1 0.18 11.2 0.1 2.8 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 CDI74387.1 - 0.0088 16.4 0.1 0.033 14.5 0.1 1.9 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 CDI74387.1 - 0.016 15.0 0.1 0.22 11.3 0.0 2.4 1 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_28 PF13521.6 CDI74387.1 - 0.02 15.2 0.4 1.1 9.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CDI74387.1 - 0.033 13.4 0.0 0.058 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_3 PF07726.11 CDI74387.1 - 0.054 13.4 0.1 0.31 10.9 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDI74387.1 - 0.055 13.0 0.0 0.14 11.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2075 PF09848.9 CDI74387.1 - 0.085 12.1 1.0 0.35 10.1 0.0 2.3 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 CDI74387.1 - 0.13 12.8 0.5 1.9 8.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CDI74387.1 - 0.16 12.5 0.1 3.3 8.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 CDI74387.1 - 0.55 10.4 3.4 0.26 11.5 0.1 2.2 2 1 0 2 2 2 0 AAA domain Not3 PF04065.15 CDI74389.1 - 0.00047 19.7 4.4 0.0006 19.3 4.4 1.3 1 1 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component TetR PF13972.6 CDI74389.1 - 0.024 14.3 0.6 0.041 13.6 0.3 1.5 1 1 0 1 1 1 0 Bacterial transcriptional repressor Filament PF00038.21 CDI74389.1 - 0.034 13.7 9.5 0.066 12.8 9.5 1.5 1 1 0 1 1 1 0 Intermediate filament protein Tautomerase_2 PF14552.6 CDI74389.1 - 0.042 13.9 0.1 0.062 13.4 0.1 1.3 1 0 0 1 1 1 0 Tautomerase enzyme CLZ PF16526.5 CDI74389.1 - 0.044 14.1 1.0 0.044 14.1 1.0 2.6 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Syntaxin-6_N PF09177.11 CDI74389.1 - 0.077 13.6 4.2 0.12 13.0 4.2 1.4 1 1 0 1 1 1 0 Syntaxin 6, N-terminal HU-CCDC81_bac_2 PF18175.1 CDI74389.1 - 0.086 12.7 3.4 0.48 10.3 0.3 2.7 2 1 1 3 3 3 0 CCDC81-like prokaryotic HU domain 2 GAS PF13851.6 CDI74389.1 - 0.17 11.2 12.9 0.052 12.9 9.1 1.8 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Cob_adeno_trans PF01923.18 CDI74389.1 - 0.23 11.6 3.2 0.25 11.5 2.7 1.3 1 1 0 1 1 1 0 Cobalamin adenosyltransferase Cnn_1N PF07989.11 CDI74389.1 - 0.25 11.5 7.3 0.33 11.1 2.2 2.5 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 DUF1664 PF07889.12 CDI74389.1 - 0.27 11.3 3.8 1 9.4 3.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) NBD_C PF17042.5 CDI74389.1 - 0.35 11.4 4.4 0.42 11.1 4.4 1.2 1 0 0 1 1 1 0 Nucleotide-binding C-terminal domain ADIP PF11559.8 CDI74389.1 - 0.5 10.5 11.9 0.22 11.6 9.0 1.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Tropomyosin_1 PF12718.7 CDI74389.1 - 0.7 10.0 14.3 0.34 11.1 9.6 2.5 1 1 0 1 1 1 0 Tropomyosin like Spc7 PF08317.11 CDI74389.1 - 1 8.1 11.5 1.4 7.7 11.5 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein CC2-LZ PF16516.5 CDI74389.1 - 1.2 9.5 12.4 0.64 10.4 1.8 2.8 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FliJ PF02050.16 CDI74389.1 - 1.7 8.9 14.6 19 5.5 1.0 2.2 1 1 1 2 2 2 0 Flagellar FliJ protein UPF0242 PF06785.11 CDI74389.1 - 3.5 7.7 12.9 6 6.9 12.9 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 CDI74389.1 - 5.4 6.0 9.1 2.4 7.2 6.5 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.14 CDI74389.1 - 5.8 7.2 14.9 4.4 7.7 6.2 1.9 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Cation_efflux PF01545.21 CDI74390.1 - 3e-36 125.0 14.2 4.7e-35 121.1 14.2 2.0 1 1 0 1 1 1 1 Cation efflux family DUF4834 PF16118.5 CDI74390.1 - 0.48 11.4 0.0 0.48 11.4 0.0 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) DUF4050 PF13259.6 CDI74391.1 - 0.00065 20.1 0.5 0.0012 19.2 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4050) CwsA PF10814.8 CDI74391.1 - 0.019 15.1 2.6 0.059 13.5 2.6 1.9 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA DNA_pol_A_exo1 PF01612.20 CDI74392.1 - 3.6e-35 121.3 0.0 6.9e-35 120.3 0.0 1.5 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 CDI74392.1 - 6.1e-12 45.4 0.0 1.3e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 HRDC domain PMC2NT PF08066.12 CDI74392.1 - 0.57 10.9 6.1 0.16 12.7 0.2 3.1 3 1 0 3 3 3 0 PMC2NT (NUC016) domain RNase_T PF00929.24 CDI74393.1 - 2.4e-29 103.0 0.0 9.3e-16 58.8 0.0 2.1 1 1 1 2 2 2 2 Exonuclease PGAP1 PF07819.13 CDI74393.1 - 0.019 14.7 0.1 0.03 14.0 0.1 1.3 1 0 0 1 1 1 0 PGAP1-like protein GYF PF02213.16 CDI74394.1 - 1.8e-16 59.5 0.0 1.8e-16 59.5 0.0 1.9 2 0 0 2 2 2 1 GYF domain eIF2A PF08662.11 CDI74395.1 - 1.8e-40 138.9 0.0 9.7e-35 120.2 0.0 3.3 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A TRAM_LAG1_CLN8 PF03798.16 CDI74396.1 - 4.9e-18 65.6 7.6 8.1e-18 64.9 7.6 1.3 1 0 0 1 1 1 1 TLC domain HemY_N PF07219.13 CDI74396.1 - 0.049 13.8 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 HemY protein N-terminus GP24_25 PF17388.2 CDI74397.1 - 0.034 14.1 0.0 0.069 13.1 0.0 1.5 1 0 0 1 1 1 0 Tail assembly gene products 24 & 25 DUF4079 PF13301.6 CDI74398.1 - 0.073 13.2 0.1 0.24 11.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) DUF2722 PF10846.8 CDI74398.1 - 1.6 7.6 13.8 0.014 14.4 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Ribosomal_60s PF00428.19 CDI74398.1 - 5.2 7.7 19.2 0.51 11.0 9.4 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Arf PF00025.21 CDI74399.1 - 2.3e-21 76.0 0.0 5.4e-19 68.3 0.1 2.1 1 1 1 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.20 CDI74399.1 - 5.5e-05 22.5 0.0 7.4e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Roc PF08477.13 CDI74399.1 - 0.045 14.0 0.0 0.07 13.4 0.0 1.2 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ribosomal_60s PF00428.19 CDI74399.1 - 0.22 12.2 10.9 0.37 11.4 10.9 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein RRM_1 PF00076.22 CDI74401.1 - 5.8e-07 29.2 0.0 1.7e-06 27.7 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDI74401.1 - 0.08 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif SR-25 PF10500.9 CDI74401.1 - 0.15 11.6 19.7 0.25 10.9 7.0 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4523 PF15023.6 CDI74401.1 - 0.65 9.8 7.8 0.029 14.2 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) PAT1 PF09770.9 CDI74401.1 - 6.8 4.8 28.2 9.1 4.4 28.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Helicase_C PF00271.31 CDI74402.1 - 4.4e-13 49.5 0.0 4.4e-13 49.5 0.0 5.0 6 2 1 7 7 7 1 Helicase conserved C-terminal domain CD20 PF04103.15 CDI74402.1 - 0.029 14.4 0.2 0.029 14.4 0.2 7.1 6 2 1 7 7 7 0 CD20-like family K_channel_TID PF07941.11 CDI74404.1 - 0.33 11.4 10.7 1.5 9.3 10.7 2.1 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Utp14 PF04615.13 CDI74404.1 - 1.3 7.5 84.6 1.5 7.3 84.6 1.0 1 0 0 1 1 1 0 Utp14 protein RskA PF10099.9 CDI74404.1 - 8.5 6.6 28.8 0.18 12.0 19.7 2.6 2 2 0 2 2 2 0 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI74405.1 - 0.0001 21.4 4.6 0.0002 20.4 4.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI74405.1 - 0.00036 20.6 27.1 0.00044 20.4 27.1 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI74405.1 - 0.00089 18.9 10.5 0.00089 18.9 10.5 1.7 2 0 0 2 2 2 1 Spt20 family Med15 PF09606.10 CDI74405.1 - 0.42 9.2 23.4 0.59 8.7 23.4 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Hamartin PF04388.12 CDI74405.1 - 1.6 7.3 9.1 1.8 7.1 9.1 1.1 1 0 0 1 1 1 0 Hamartin protein Presenilin PF01080.17 CDI74406.1 - 0.074 11.8 42.6 0.028 13.2 20.5 2.3 2 0 0 2 2 2 0 Presenilin Apt1 PF10351.9 CDI74406.1 - 5.9 5.6 45.5 4.1 6.2 11.7 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain CDC27 PF09507.10 CDI74406.1 - 5.9 6.2 44.1 1.1 8.6 10.4 2.1 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 SUIM_assoc PF16619.5 CDI74408.1 - 0.002 18.1 0.2 0.002 18.1 0.2 8.8 8 2 0 8 8 8 3 Unstructured region C-term to UIM in Ataxin3 ESM4 PF15952.5 CDI74408.1 - 0.0086 16.5 45.2 0.035 14.5 13.4 3.6 3 0 0 3 3 3 2 Enhancer of split M4 family Sec62 PF03839.16 CDI74408.1 - 0.025 14.1 0.4 0.025 14.1 0.4 2.9 2 0 0 2 2 2 0 Translocation protein Sec62 RR_TM4-6 PF06459.12 CDI74408.1 - 0.54 10.0 33.8 2.6 7.8 15.6 2.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 MFS_Mycoplasma PF07672.13 CDI74408.1 - 0.86 8.8 0.0 0.86 8.8 0.0 3.3 5 0 0 5 5 5 0 Mycoplasma MFS transporter SAGA-Tad1 PF12767.7 CDI74408.1 - 2.3 7.9 35.1 0.12 12.1 12.9 3.0 3 1 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit Cwf_Cwc_15 PF04889.12 CDI74408.1 - 2.7 7.7 37.9 2.7 7.7 14.1 2.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SART-1 PF03343.13 CDI74408.1 - 3.9 5.9 41.5 2.8 6.4 18.9 2.3 2 0 0 2 2 2 0 SART-1 family GAGA_bind PF06217.12 CDI74408.1 - 4.3 7.5 35.0 1.3 9.2 8.5 3.2 3 0 0 3 3 3 0 GAGA binding protein-like family RNase_PH PF01138.21 CDI74410.1 - 4.8e-14 53.0 0.1 3.3e-13 50.3 0.1 2.0 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 Presenilin PF01080.17 CDI74411.1 - 3.4 6.3 44.1 4 6.1 44.1 1.0 1 0 0 1 1 1 0 Presenilin DUF2052 PF09747.9 CDI74411.1 - 4 7.5 34.6 4.4 7.4 34.6 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4746 PF15928.5 CDI74411.1 - 4.4 6.6 27.7 4.7 6.5 27.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FAM60A PF15396.6 CDI74411.1 - 5 7.1 29.1 6 6.8 29.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A RR_TM4-6 PF06459.12 CDI74411.1 - 6.6 6.5 40.3 7.8 6.2 40.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Gti1_Pac2 PF09729.9 CDI74411.1 - 9.7 6.2 30.4 12 5.9 30.4 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Pkinase PF00069.25 CDI74412.1 - 5.6e-53 180.0 0.0 5.6e-53 180.0 0.0 2.7 3 1 1 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI74412.1 - 2.5e-20 72.9 0.1 7e-20 71.4 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase AP3D1 PF06375.11 CDI74415.1 - 0.26 11.5 10.7 0.029 14.6 2.1 3.4 4 0 0 4 4 4 0 AP-3 complex subunit delta-1 DUF1908 PF08926.11 CDI74415.1 - 1.5 7.8 7.3 0.59 9.2 3.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1908) Velvet PF11754.8 CDI74417.1 - 9.3e-05 22.5 22.1 9.3e-05 22.5 22.1 2.1 2 0 0 2 2 2 1 Velvet factor V_ATPase_I PF01496.19 CDI74417.1 - 0.00081 17.5 20.8 0.00081 17.5 20.8 2.2 2 0 0 2 2 2 2 V-type ATPase 116kDa subunit family DUF572 PF04502.13 CDI74417.1 - 0.0023 17.6 32.2 0.026 14.2 20.0 2.1 2 0 0 2 2 2 2 Family of unknown function (DUF572) Zip PF02535.22 CDI74417.1 - 0.0028 16.9 11.1 0.0028 16.9 11.1 2.1 2 0 0 2 2 2 1 ZIP Zinc transporter DUF2722 PF10846.8 CDI74417.1 - 0.0066 15.5 10.2 0.0066 15.5 10.2 4.1 2 1 2 4 4 1 1 Protein of unknown function (DUF2722) RIFIN PF02009.16 CDI74417.1 - 0.31 10.9 24.8 0.95 9.3 1.4 2.1 2 0 0 2 2 2 0 Rifin TerC PF03741.16 CDI74417.1 - 0.41 10.3 0.0 0.41 10.3 0.0 2.5 3 0 0 3 3 2 0 Integral membrane protein TerC family MMR1 PF08505.10 CDI74417.1 - 0.54 10.5 55.3 2.1 8.6 39.1 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein SAPS PF04499.15 CDI74417.1 - 0.56 8.9 29.0 2.8 6.6 0.3 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein MscL PF01741.18 CDI74417.1 - 0.79 10.0 0.0 0.79 10.0 0.0 3.4 3 1 0 3 3 2 0 Large-conductance mechanosensitive channel, MscL DREPP PF05558.12 CDI74417.1 - 2.2 8.1 5.7 3.1 7.6 3.2 2.2 2 0 0 2 2 2 0 DREPP plasma membrane polypeptide Endostatin PF06482.11 CDI74417.1 - 2.4 7.6 39.5 0.7 9.3 25.1 2.2 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Isy1 PF06246.12 CDI74417.1 - 2.6 7.6 42.6 0.9 9.0 4.7 2.1 2 0 0 2 2 2 0 Isy1-like splicing family DUF4407 PF14362.6 CDI74417.1 - 3.2 7.0 47.6 3 7.1 30.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Neur_chan_memb PF02932.16 CDI74417.1 - 4.3 7.3 36.6 1.3 9.1 21.6 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PA26 PF04636.13 CDI74417.1 - 5.1 5.9 32.3 0.3 10.0 17.9 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Suf PF05843.14 CDI74417.1 - 7.4 6.5 60.1 1.3 9.0 11.0 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) SLC12 PF03522.15 CDI74417.1 - 8 5.4 46.5 1.2 8.1 30.6 2.1 2 0 0 2 2 2 0 Solute carrier family 12 DUF4569 PF15133.6 CDI74417.1 - 8 6.1 48.5 1.3 8.7 8.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4569) SAGA-Tad1 PF12767.7 CDI74417.1 - 9.2 5.9 37.7 7.8 6.2 23.7 2.3 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit Spt20 PF12090.8 CDI74418.1 - 0.001 18.8 20.3 0.001 18.8 20.3 23.4 12 8 4 16 16 16 4 Spt20 family TFIIA PF03153.13 CDI74419.1 - 3.1 7.7 30.6 4.2 7.3 30.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI74419.1 - 3.5 7.6 6.7 3.7 7.5 6.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AAA_23 PF13476.6 CDI74419.1 - 9.3 6.7 14.2 13 6.2 14.2 1.3 1 0 0 1 1 1 0 AAA domain Sperm_Ag_HE2 PF05324.13 CDI74420.1 - 0.071 13.6 0.0 0.35 11.4 0.0 2.3 1 0 0 1 1 1 0 Sperm antigen HE2 RskA PF10099.9 CDI74421.1 - 0.025 14.9 12.6 0.025 14.9 12.6 6.5 1 1 2 4 4 4 0 Anti-sigma-K factor rskA DUF4179 PF13786.6 CDI74421.1 - 6.6 7.3 14.8 2.3 8.8 0.6 4.2 3 3 0 3 3 3 0 Domain of unknown function (DUF4179) PIP5K PF01504.18 CDI74422.1 - 2.2 7.4 21.8 2.2 7.4 21.8 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase MAP17 PF15807.5 CDI74422.1 - 2.2 8.5 18.8 2.3 8.5 18.8 1.0 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Tim54 PF11711.8 CDI74422.1 - 2.4 6.9 24.4 2.5 6.8 24.4 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 KASH PF10541.9 CDI74424.1 - 0.1 12.8 1.0 0.37 11.1 0.6 2.1 2 0 0 2 2 2 0 Nuclear envelope localisation domain TFIID_NTD2 PF04494.15 CDI74424.1 - 1.1 9.5 7.6 4.4 7.5 0.1 3.8 3 1 0 3 3 3 0 WD40 associated region in TFIID subunit, NTD2 domain Drc1-Sld2 PF11719.8 CDI74425.1 - 1.8 8.0 12.9 0.16 11.4 1.0 2.8 2 1 1 3 3 3 0 DNA replication and checkpoint protein DUF4366 PF14283.6 CDI74426.1 - 0.11 12.6 15.1 0.05 13.7 1.5 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) DUF2052 PF09747.9 CDI74426.1 - 0.18 11.9 21.1 0.79 9.8 15.0 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) FAM60A PF15396.6 CDI74426.1 - 0.18 11.8 14.0 0.15 12.1 10.1 2.1 2 0 0 2 2 2 0 Protein Family FAM60A DUF4050 PF13259.6 CDI74426.1 - 0.39 11.0 15.8 0.16 12.3 9.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) Afi1 PF07792.12 CDI74426.1 - 0.53 10.8 17.7 1.6 9.2 16.2 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Gti1_Pac2 PF09729.9 CDI74426.1 - 0.69 10.0 15.3 0.46 10.5 11.4 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family DUF572 PF04502.13 CDI74426.1 - 0.78 9.3 16.8 0.72 9.4 11.5 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) LMBR1 PF04791.16 CDI74426.1 - 0.83 8.5 11.3 1.2 8.0 11.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein HCO3_cotransp PF00955.21 CDI74426.1 - 1.1 8.0 9.0 1.7 7.3 9.0 1.3 1 0 0 1 1 1 0 HCO3- transporter family CCDC53 PF10152.9 CDI74426.1 - 1.6 9.2 28.9 1.7 9.1 15.3 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex TYW3 PF02676.14 CDI74426.1 - 1.7 8.0 9.1 0.69 9.2 5.9 2.0 2 0 0 2 2 2 0 Methyltransferase TYW3 Rtf2 PF04641.12 CDI74426.1 - 1.9 7.8 20.1 0.49 9.7 11.6 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger SARAF PF06682.12 CDI74426.1 - 2.2 7.9 21.5 20 4.7 0.0 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis MDM10 PF12519.8 CDI74426.1 - 2.2 7.0 14.0 0.9 8.3 10.9 1.7 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 Endostatin PF06482.11 CDI74426.1 - 2.3 7.6 24.6 5.3 6.4 16.8 2.1 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin RR_TM4-6 PF06459.12 CDI74426.1 - 2.9 7.6 24.4 1.1 9.1 18.9 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DDRGK PF09756.9 CDI74427.1 - 0.092 12.3 19.9 0.2 11.2 19.9 1.5 1 0 0 1 1 1 0 DDRGK domain Asp-B-Hydro_N PF05279.11 CDI74427.1 - 0.69 9.9 10.9 0.9 9.6 10.9 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Mitofilin PF09731.9 CDI74427.1 - 8 5.2 28.1 9.6 4.9 28.1 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Secretin_N_2 PF07655.13 CDI74428.1 - 0.17 12.4 12.2 3.8 8.1 11.7 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain Ctr PF04145.15 CDI74428.1 - 0.18 12.4 2.5 0.91 10.1 2.5 2.5 1 1 0 1 1 1 0 Ctr copper transporter family Apt1 PF10351.9 CDI74428.1 - 1 8.1 4.9 1.6 7.5 4.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_S64 PF08192.11 CDI74428.1 - 9.8 4.5 7.7 15 3.9 7.7 1.2 1 0 0 1 1 1 0 Peptidase family S64 DEAD PF00270.29 CDI74429.1 - 0.00045 20.0 29.7 0.0071 16.1 0.0 4.0 3 2 1 4 4 4 3 DEAD/DEAH box helicase DUF3155 PF11352.8 CDI74429.1 - 0.065 13.7 0.2 0.065 13.7 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3155) RskA PF10099.9 CDI74429.1 - 0.11 12.8 39.8 1.8e+04 -7.3 39.8 3.2 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF4604 PF15377.6 CDI74429.1 - 4.6 7.6 58.2 0.94 9.9 13.6 3.4 2 1 0 3 3 3 0 Domain of unknown function (DUF4604) TFIIA PF03153.13 CDI74429.1 - 8.7 6.2 108.3 0.12 12.3 59.9 2.2 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI74430.1 - 0.0001 22.0 5.2 0.0001 22.0 5.2 10.2 9 1 1 10 10 10 4 Spt20 family TFIIA PF03153.13 CDI74430.1 - 0.001 19.2 38.4 0.001 19.2 38.4 7.3 5 3 2 7 7 7 2 Transcription factor IIA, alpha/beta subunit PRP1_N PF06424.12 CDI74430.1 - 0.0062 16.9 3.4 0.0062 16.9 3.4 6.7 7 0 0 7 7 7 1 PRP1 splicing factor, N-terminal DUF4667 PF15700.5 CDI74430.1 - 0.43 10.7 0.0 0.43 10.7 0.0 9.0 6 2 1 8 8 8 0 Domain of unknown function (DUF4667) RskA PF10099.9 CDI74431.1 - 0.3 11.4 13.0 0.35 11.1 13.0 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Helicase_C PF00271.31 CDI74432.1 - 3.2e-15 56.4 0.0 6.4e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HSP9_HSP12 PF04119.12 CDI74432.1 - 0.018 15.4 1.2 0.056 13.8 1.2 1.9 1 0 0 1 1 1 0 Heat shock protein 9/12 TBCC_N PF16752.5 CDI74432.1 - 0.031 14.7 2.1 0.1 13.0 2.1 1.8 1 1 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain NPR1_interact PF15699.5 CDI74434.1 - 0.036 14.7 18.6 0.049 14.3 18.6 1.1 1 0 0 1 1 1 0 NPR1 interacting eIF3_subunit PF08597.10 CDI74434.1 - 0.15 12.0 20.6 0.22 11.4 20.6 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF4604 PF15377.6 CDI74434.1 - 0.16 12.4 23.4 0.14 12.6 9.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) DUF5523 PF17661.1 CDI74434.1 - 0.43 10.2 19.2 0.51 10.0 19.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) SMYLE_N PF18615.1 CDI74434.1 - 0.53 9.8 10.5 0.61 9.6 10.5 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain AUX_IAA PF02309.16 CDI74434.1 - 0.65 9.8 8.5 0.8 9.5 8.5 1.1 1 0 0 1 1 1 0 AUX/IAA family FAM60A PF15396.6 CDI74434.1 - 0.69 9.9 15.7 0.8 9.7 15.7 1.0 1 0 0 1 1 1 0 Protein Family FAM60A ALMT PF11744.8 CDI74434.1 - 0.89 8.3 10.7 1 8.1 10.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF5427 PF10310.9 CDI74434.1 - 1.2 8.0 17.6 1.4 7.8 17.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF3602 PF12223.8 CDI74434.1 - 1.3 9.6 8.1 0.15 12.6 2.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3602) U1snRNP70_N PF12220.8 CDI74434.1 - 1.4 9.7 20.6 2.3 8.9 4.1 2.1 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal MAJIN PF15077.6 CDI74434.1 - 1.4 8.7 12.2 1.6 8.5 12.2 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein THOC2_N PF16134.5 CDI74434.1 - 1.5 7.4 13.4 1.7 7.2 13.4 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus GN3L_Grn1 PF08701.11 CDI74434.1 - 2.1 8.5 29.4 6.4 6.9 29.4 1.8 1 1 0 1 1 1 0 GNL3L/Grn1 putative GTPase Spore_coat_CotO PF14153.6 CDI74434.1 - 2.2 8.2 21.2 3 7.7 21.2 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DUF2828 PF11443.8 CDI74434.1 - 2.6 6.1 14.7 3 5.8 14.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) XRN_M PF17846.1 CDI74434.1 - 2.6 6.9 13.9 3.1 6.7 13.9 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Conotoxin PF02950.17 CDI74434.1 - 2.9 9.0 12.0 5 8.2 4.5 2.1 2 0 0 2 2 2 0 Conotoxin Presenilin PF01080.17 CDI74434.1 - 3 6.5 17.5 3.3 6.4 17.5 1.0 1 0 0 1 1 1 0 Presenilin E7 PF00527.18 CDI74434.1 - 3.1 8.1 13.1 1.4 9.1 7.5 2.0 2 0 0 2 2 2 0 E7 protein, Early protein O-antigen_lig PF13425.6 CDI74434.1 - 3.3 6.4 6.4 4.2 6.0 6.4 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Gti1_Pac2 PF09729.9 CDI74434.1 - 3.8 7.5 12.6 5.3 7.1 12.6 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family PA26 PF04636.13 CDI74434.1 - 4 6.3 12.0 4.6 6.1 12.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PBP_sp32 PF07222.12 CDI74434.1 - 4.9 6.5 19.2 7.2 6.0 19.2 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF3959 PF13105.6 CDI74434.1 - 5.1 6.5 13.1 6.4 6.2 13.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) Neur_chan_memb PF02932.16 CDI74434.1 - 6.1 6.8 12.8 6.7 6.7 12.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 CDI74434.1 - 7.1 5.7 12.5 9.3 5.4 12.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter ERK-JNK_inhib PF15002.6 CDI74434.1 - 7.3 6.2 20.5 2.1 8.0 7.1 2.1 2 0 0 2 2 2 0 ERK and JNK pathways, inhibitor SLC12 PF03522.15 CDI74434.1 - 7.6 5.4 16.4 9 5.2 16.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 TMEM214 PF10151.9 CDI74434.1 - 7.6 4.9 16.2 9.2 4.6 16.2 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Androgen_recep PF02166.16 CDI74434.1 - 7.7 5.2 18.6 9.7 4.9 18.6 1.2 1 0 0 1 1 1 0 Androgen receptor DUF4834 PF16118.5 CDI74434.1 - 8.2 7.5 17.8 1.8 9.6 7.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF4395 PF14340.6 CDI74435.1 - 0.45 10.9 12.7 0.23 11.8 5.3 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4395) PAT1 PF09770.9 CDI74436.1 - 0.075 11.3 33.0 0.087 11.1 33.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FapA PF03961.13 CDI74436.1 - 0.092 11.3 11.2 0.11 11.0 11.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF2652 PF10851.8 CDI74436.1 - 4.7 7.4 9.7 1.7 8.8 1.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2652) AI-2E_transport PF01594.16 CDI74436.1 - 8.7 5.4 5.1 17 4.4 5.1 1.4 1 0 0 1 1 1 0 AI-2E family transporter ANAPC4_WD40 PF12894.7 CDI74437.1 - 7.2e-12 45.4 0.1 0.00072 19.8 0.0 4.7 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDI74437.1 - 3.2e-09 37.2 4.2 0.027 15.3 0.1 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 CDI74437.1 - 9.5e-05 21.5 0.3 0.00097 18.2 0.0 2.4 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein SGL PF08450.12 CDI74437.1 - 0.03 13.9 0.0 3.5 7.1 0.0 3.0 3 0 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Mob1_phocein PF03637.17 CDI74438.1 - 6.2e-12 45.9 0.0 1.2e-09 38.5 0.0 2.2 2 0 0 2 2 2 2 Mob1/phocein family EIF_2_alpha PF07541.12 CDI74439.1 - 6.8e-23 81.0 0.0 1.1e-22 80.3 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 CDI74439.1 - 1.4e-10 41.4 1.2 2.3e-10 40.6 0.2 2.0 2 0 0 2 2 2 1 S1 RNA binding domain Phage_1_1 PF08200.11 CDI74439.1 - 0.15 12.5 0.1 0.4 11.1 0.1 1.7 1 0 0 1 1 1 0 Bacteriophage 1.1 Protein V_ATPase_I PF01496.19 CDI74440.1 - 0.014 13.3 7.4 0.016 13.2 7.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1180 PF06679.12 CDI74440.1 - 0.025 15.0 3.3 0.033 14.6 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Conotoxin PF02950.17 CDI74440.1 - 0.047 14.7 0.4 0.047 14.7 0.4 2.3 1 1 1 2 2 1 0 Conotoxin CLN3 PF02487.17 CDI74440.1 - 0.053 12.6 4.1 0.06 12.4 4.1 1.1 1 0 0 1 1 1 0 CLN3 protein SID-1_RNA_chan PF13965.6 CDI74440.1 - 0.055 11.9 0.7 0.061 11.7 0.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2828 PF11443.8 CDI74440.1 - 0.094 10.8 7.8 0.11 10.5 7.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Serinc PF03348.15 CDI74440.1 - 0.15 10.9 0.7 0.16 10.8 0.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Zip PF02535.22 CDI74440.1 - 0.17 11.1 0.7 0.18 11.0 0.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter GET2 PF08690.10 CDI74440.1 - 0.18 11.5 9.5 0.23 11.1 9.5 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 FAM176 PF14851.6 CDI74440.1 - 0.19 11.4 6.2 1.7 8.3 2.6 2.0 2 0 0 2 2 2 0 FAM176 family DUF4407 PF14362.6 CDI74440.1 - 0.33 10.3 13.4 0.42 9.9 13.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GRP PF07172.11 CDI74440.1 - 0.35 11.6 0.0 0.35 11.6 0.0 2.2 1 1 0 2 2 2 0 Glycine rich protein family CSG2 PF16965.5 CDI74440.1 - 0.54 9.2 1.5 0.58 9.0 1.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator MAJIN PF15077.6 CDI74440.1 - 0.56 9.9 9.4 0.65 9.8 9.4 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Neur_chan_memb PF02932.16 CDI74440.1 - 0.68 9.9 7.4 0.83 9.7 7.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.10 CDI74440.1 - 0.87 8.2 8.6 1 8.0 8.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4446 PF14584.6 CDI74440.1 - 1.5 8.8 6.3 20 5.2 5.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Pex14_N PF04695.13 CDI74440.1 - 1.6 9.4 16.0 2.4 8.8 16.0 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ALMT PF11744.8 CDI74440.1 - 2 7.2 8.2 2.3 6.9 8.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter RR_TM4-6 PF06459.12 CDI74440.1 - 3.5 7.4 12.6 4.7 7.0 12.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Suf PF05843.14 CDI74440.1 - 5.3 6.9 17.6 6.8 6.6 17.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 CDI74440.1 - 5.5 5.6 16.3 6.9 5.3 16.3 1.1 1 0 0 1 1 1 0 Presenilin DUF3959 PF13105.6 CDI74440.1 - 5.7 6.4 10.7 6.5 6.2 10.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) Band_3_cyto PF07565.13 CDI74440.1 - 7.2 6.3 13.1 9 6.0 13.1 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain HemX PF04375.14 CDI74440.1 - 8.1 5.6 25.8 11 5.2 25.8 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Fe_hyd_lg_C PF02906.14 CDI74441.1 - 1.6 8.3 6.6 2.7 7.6 6.6 1.4 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain RIFIN PF02009.16 CDI74442.1 - 0.0045 16.9 14.8 0.0057 16.6 14.8 1.0 1 0 0 1 1 1 1 Rifin DUF913 PF06025.12 CDI74442.1 - 0.0062 15.6 10.7 0.0073 15.3 10.7 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) SARG PF15385.6 CDI74442.1 - 0.016 14.4 21.8 0.019 14.2 21.8 1.1 1 0 0 1 1 1 0 Specifically androgen-regulated gene protein TFIIA PF03153.13 CDI74442.1 - 0.034 14.2 46.7 0.053 13.5 46.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 CDI74442.1 - 0.035 13.9 25.3 0.041 13.7 25.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 CDI74442.1 - 0.041 13.9 19.1 0.05 13.7 19.1 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MID_MedPIWI PF18296.1 CDI74442.1 - 0.048 13.5 17.2 0.056 13.2 17.2 1.1 1 0 0 1 1 1 0 MID domain of medPIWI Presenilin PF01080.17 CDI74442.1 - 0.051 12.3 26.7 0.063 12.0 26.7 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI74442.1 - 0.06 12.4 23.7 0.068 12.2 23.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Afi1 PF07792.12 CDI74442.1 - 0.062 13.8 18.6 0.092 13.2 18.6 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF3112 PF11309.8 CDI74442.1 - 0.065 12.7 2.1 0.087 12.3 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Zip PF02535.22 CDI74442.1 - 0.065 12.4 8.7 0.069 12.4 8.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SID-1_RNA_chan PF13965.6 CDI74442.1 - 0.076 11.4 8.3 0.089 11.2 8.3 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PAT1 PF09770.9 CDI74442.1 - 0.079 11.2 34.0 0.082 11.2 34.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 V_ATPase_I PF01496.19 CDI74442.1 - 0.16 9.9 21.5 0.19 9.6 21.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rrn6 PF10214.9 CDI74442.1 - 0.19 10.2 22.4 0.2 10.1 22.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor XRN_M PF17846.1 CDI74442.1 - 0.2 10.6 15.1 0.22 10.4 15.1 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Endostatin PF06482.11 CDI74442.1 - 0.2 11.1 19.6 0.24 10.8 19.6 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin GAGA_bind PF06217.12 CDI74442.1 - 0.21 11.9 19.4 0.23 11.7 19.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family AAA_11 PF13086.6 CDI74442.1 - 0.24 11.2 21.3 0.27 11.0 21.3 1.1 1 0 0 1 1 1 0 AAA domain DUF2052 PF09747.9 CDI74442.1 - 0.25 11.5 25.2 0.32 11.1 25.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4045 PF13254.6 CDI74442.1 - 0.32 10.6 21.4 0.38 10.3 21.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF4050 PF13259.6 CDI74442.1 - 0.42 10.9 20.7 0.56 10.5 20.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Nha1_C PF08619.10 CDI74442.1 - 0.44 9.7 28.8 0.55 9.4 28.8 1.0 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus DUF4746 PF15928.5 CDI74442.1 - 0.74 9.2 19.9 0.93 8.9 19.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TCP PF03634.13 CDI74442.1 - 0.78 10.3 22.5 1.1 9.8 22.5 1.3 1 0 0 1 1 1 0 TCP family transcription factor Exonuc_VII_L PF02601.15 CDI74442.1 - 0.82 9.2 21.5 0.86 9.1 21.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Band_3_cyto PF07565.13 CDI74442.1 - 0.87 9.3 19.0 1.3 8.8 19.0 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain ALMT PF11744.8 CDI74442.1 - 1.2 7.9 19.6 1.4 7.6 19.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter NPR3 PF03666.13 CDI74442.1 - 1.2 7.8 22.2 1.5 7.5 22.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 CDI74442.1 - 1.3 7.2 22.1 1.6 6.9 22.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Membralin PF09746.9 CDI74442.1 - 1.6 7.7 15.2 1.8 7.5 15.2 1.1 1 0 0 1 1 1 0 Tumour-associated protein HemX PF04375.14 CDI74442.1 - 1.6 7.9 41.0 2.2 7.5 41.0 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase CCSAP PF15748.5 CDI74442.1 - 1.6 8.8 30.2 2.1 8.5 30.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Peptidase_S49_N PF08496.10 CDI74442.1 - 1.9 8.5 29.7 1.1e+02 2.8 29.7 2.1 1 1 0 1 1 1 0 Peptidase family S49 N-terminal DUF4175 PF13779.6 CDI74442.1 - 2 6.2 47.2 2.2 6.1 47.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) NARP1 PF12569.8 CDI74442.1 - 2.1 7.1 25.4 2.6 6.8 25.4 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF2828 PF11443.8 CDI74442.1 - 2.3 6.2 22.2 2.8 5.9 22.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Mem_trans PF03547.18 CDI74442.1 - 3.1 6.1 8.0 3.9 5.8 8.0 1.1 1 0 0 1 1 1 0 Membrane transport protein PTPRCAP PF15713.5 CDI74442.1 - 3.4 7.9 24.3 6 7.1 24.3 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated PA26 PF04636.13 CDI74442.1 - 3.4 6.5 19.0 4.1 6.2 19.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Hid1 PF12722.7 CDI74442.1 - 3.5 5.6 23.8 4.2 5.4 23.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein O-antigen_lig PF13425.6 CDI74442.1 - 3.8 6.2 12.2 4.6 5.9 12.2 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein TT_ORF1 PF02956.14 CDI74442.1 - 3.9 6.0 20.5 4.9 5.7 20.5 1.1 1 0 0 1 1 1 0 TT viral orf 1 Dapper PF15268.6 CDI74442.1 - 4.1 6.2 30.4 4.9 5.9 30.4 1.0 1 0 0 1 1 1 0 Dapper VIR_N PF15912.5 CDI74442.1 - 4.1 6.9 18.7 5.2 6.6 18.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal RP-C_C PF11800.8 CDI74442.1 - 4.4 7.3 21.5 5.7 7.0 21.5 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region DDRGK PF09756.9 CDI74442.1 - 4.9 6.7 38.1 7.5 6.1 38.1 1.2 1 0 0 1 1 1 0 DDRGK domain BORG_CEP PF14957.6 CDI74442.1 - 4.9 8.3 18.3 6.9 7.9 18.3 1.2 1 0 0 1 1 1 0 Cdc42 effector Phage_GPO PF05929.11 CDI74442.1 - 5.2 6.6 24.6 6.1 6.4 24.6 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase CLN3 PF02487.17 CDI74442.1 - 5.4 5.9 22.9 29 3.6 22.9 1.8 1 1 0 1 1 1 0 CLN3 protein DUF2370 PF10176.9 CDI74442.1 - 6.8 6.3 13.8 9.7 5.8 13.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) FemAB PF02388.16 CDI74442.1 - 7.7 5.3 25.2 9.8 4.9 25.2 1.1 1 0 0 1 1 1 0 FemAB family Rtf2 PF04641.12 CDI74442.1 - 7.8 5.8 28.1 10 5.4 28.1 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2126 PF09899.9 CDI74442.1 - 8.9 4.2 17.2 12 3.8 17.2 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) PPL5 PF18168.1 CDI74442.1 - 9.2 5.5 19.6 13 5.0 19.6 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Plasmodium_Vir PF05795.11 CDI74444.1 - 0.0066 15.9 12.1 0.0072 15.8 12.1 1.0 1 0 0 1 1 1 1 Plasmodium vivax Vir protein V_ATPase_I PF01496.19 CDI74444.1 - 0.014 13.3 14.6 0.015 13.3 14.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RIFIN PF02009.16 CDI74444.1 - 0.019 14.8 13.6 0.02 14.8 13.6 1.0 1 0 0 1 1 1 0 Rifin Consortin_C PF15281.6 CDI74444.1 - 0.077 13.0 6.9 0.97 9.4 4.0 2.0 1 1 1 2 2 2 0 Consortin C-terminus DUF4366 PF14283.6 CDI74444.1 - 0.096 12.7 11.4 0.2 11.7 11.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) MAP65_ASE1 PF03999.12 CDI74444.1 - 0.12 11.0 25.3 0.14 10.8 25.3 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Endomucin PF07010.12 CDI74444.1 - 0.13 12.3 21.6 0.14 12.1 21.6 1.0 1 0 0 1 1 1 0 Endomucin INO80_Ies4 PF08193.11 CDI74444.1 - 0.13 12.2 11.1 0.2 11.6 11.1 1.3 1 0 0 1 1 1 0 INO80 complex subunit Ies4 DUF3295 PF11702.8 CDI74444.1 - 0.16 11.3 23.5 0.18 11.1 23.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Presenilin PF01080.17 CDI74444.1 - 0.16 10.7 25.6 0.17 10.6 25.6 1.0 1 0 0 1 1 1 0 Presenilin DUF1645 PF07816.11 CDI74444.1 - 0.21 12.1 11.5 0.25 11.9 11.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) ASD2 PF08687.11 CDI74444.1 - 0.21 11.1 19.3 0.23 11.0 19.3 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 CLN3 PF02487.17 CDI74444.1 - 0.22 10.5 12.4 0.22 10.5 12.4 1.1 1 0 0 1 1 1 0 CLN3 protein SKA1 PF07160.12 CDI74444.1 - 0.23 11.3 19.9 0.26 11.1 19.9 1.0 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF2052 PF09747.9 CDI74444.1 - 0.23 11.5 16.6 0.28 11.3 16.6 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4746 PF15928.5 CDI74444.1 - 0.24 10.8 9.2 0.3 10.5 9.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RR_TM4-6 PF06459.12 CDI74444.1 - 0.24 11.2 17.9 0.29 10.9 17.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Dicty_REP PF05086.12 CDI74444.1 - 0.27 9.2 20.6 0.32 8.9 20.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF913 PF06025.12 CDI74444.1 - 0.3 10.0 11.5 0.33 9.9 11.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TFIIA PF03153.13 CDI74444.1 - 0.43 10.5 40.3 0.51 10.3 40.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4698 PF15769.5 CDI74444.1 - 0.43 9.6 15.8 0.53 9.3 15.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) FAM76 PF16046.5 CDI74444.1 - 0.44 9.9 19.4 0.52 9.6 19.4 1.1 1 0 0 1 1 1 0 FAM76 protein YABBY PF04690.13 CDI74444.1 - 0.45 11.1 18.0 0.54 10.8 18.0 1.1 1 0 0 1 1 1 0 YABBY protein Zip PF02535.22 CDI74444.1 - 0.52 9.5 13.4 0.56 9.4 13.4 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter SR-25 PF10500.9 CDI74444.1 - 0.65 9.6 18.9 0.8 9.3 18.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Paramyxo_ncap PF00973.19 CDI74444.1 - 0.8 8.5 17.2 0.91 8.4 17.2 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PIP5K PF01504.18 CDI74444.1 - 0.81 8.9 13.1 1.2 8.3 13.1 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF853 PF05872.12 CDI74444.1 - 0.82 8.2 11.3 0.89 8.1 11.3 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) SLC12 PF03522.15 CDI74444.1 - 0.9 8.5 22.8 1 8.3 22.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 BORG_CEP PF14957.6 CDI74444.1 - 1 10.6 15.5 1.3 10.2 15.5 1.1 1 0 0 1 1 1 0 Cdc42 effector SMYLE_N PF18615.1 CDI74444.1 - 1 8.8 14.7 1.2 8.6 14.7 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain PAP1 PF08601.10 CDI74444.1 - 1.1 9.0 25.0 1.2 8.8 25.0 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 Pap_E4 PF02711.14 CDI74444.1 - 1.1 10.3 25.0 0.27 12.2 18.9 1.9 1 1 1 2 2 2 0 E4 protein MMR1 PF08505.10 CDI74444.1 - 1.2 9.4 29.5 1.4 9.1 29.5 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF1387 PF07139.11 CDI74444.1 - 1.2 8.8 22.5 1.6 8.4 22.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) HCO3_cotransp PF00955.21 CDI74444.1 - 1.5 7.6 12.4 1.6 7.5 12.4 1.0 1 0 0 1 1 1 0 HCO3- transporter family NST1 PF13945.6 CDI74444.1 - 1.5 8.9 32.6 2.4 8.2 32.6 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF4776 PF16003.5 CDI74444.1 - 1.9 7.4 16.9 2.1 7.3 16.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) MID_MedPIWI PF18296.1 CDI74444.1 - 2.1 8.1 20.5 3.2 7.5 20.5 1.3 1 0 0 1 1 1 0 MID domain of medPIWI FCP1_C PF09309.10 CDI74444.1 - 2.2 8.1 18.8 2.8 7.8 18.8 1.0 1 0 0 1 1 1 0 FCP1, C-terminal Endostatin PF06482.11 CDI74444.1 - 2.5 7.5 18.7 2.9 7.3 18.7 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin RED_N PF07808.13 CDI74444.1 - 2.8 7.5 21.7 3.5 7.1 21.7 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region Sin_N PF04801.13 CDI74444.1 - 3.4 6.8 29.7 4.1 6.5 29.7 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region Kinesin_assoc PF16183.5 CDI74444.1 - 3.4 7.8 7.8 3.9 7.6 7.8 1.1 1 0 0 1 1 1 0 Kinesin-associated ALMT PF11744.8 CDI74444.1 - 3.8 6.2 18.8 4.3 6.1 18.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Tim54 PF11711.8 CDI74444.1 - 4.3 6.0 16.6 5.9 5.6 16.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF5427 PF10310.9 CDI74444.1 - 4.5 6.1 24.1 5.1 5.9 24.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF2126 PF09899.9 CDI74444.1 - 4.9 5.1 11.9 5.4 5.0 11.9 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Macoilin PF09726.9 CDI74444.1 - 5.5 5.4 22.9 6.6 5.2 22.9 1.0 1 0 0 1 1 1 0 Macoilin family DAG_kinase_N PF14513.6 CDI74444.1 - 6 7.1 19.9 7.7 6.7 19.9 1.1 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Rtf2 PF04641.12 CDI74444.1 - 6.2 6.1 18.6 7.3 5.9 18.6 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger PAT1 PF09770.9 CDI74444.1 - 6.2 5.0 29.9 6.9 4.8 29.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDC45 PF02724.14 CDI74444.1 - 6.5 4.9 16.7 7.7 4.7 16.7 1.0 1 0 0 1 1 1 0 CDC45-like protein PepSY_TM PF03929.16 CDI74444.1 - 6.5 6.3 9.6 8.6 5.9 9.6 1.2 1 0 0 1 1 1 0 PepSY-associated TM region XAP5 PF04921.14 CDI74444.1 - 6.7 6.5 15.3 9.2 6.0 15.3 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator MDFI PF15316.6 CDI74444.1 - 7.3 6.6 21.8 8.7 6.4 21.8 1.0 1 0 0 1 1 1 0 MyoD family inhibitor SID-1_RNA_chan PF13965.6 CDI74444.1 - 7.4 4.8 13.0 7.6 4.8 13.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Neur_chan_memb PF02932.16 CDI74444.1 - 8.7 6.3 16.6 11 6.0 16.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sec62 PF03839.16 CDI74444.1 - 9.2 5.7 15.5 11 5.5 15.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4638 PF15472.6 CDI74444.1 - 9.7 5.8 13.7 12 5.5 13.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Afi1 PF07792.12 CDI74445.1 - 0.14 12.7 7.0 0.14 12.7 7.0 1.0 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Connexin PF00029.19 CDI74445.1 - 0.2 11.4 5.7 0.19 11.4 5.7 1.0 1 0 0 1 1 1 0 Connexin CPSF100_C PF13299.6 CDI74445.1 - 0.2 11.8 7.2 0.22 11.7 7.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FYDLN_acid PF09538.10 CDI74445.1 - 0.22 12.2 16.2 0.25 12.0 16.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Eapp_C PF10238.9 CDI74445.1 - 0.24 11.5 6.4 0.26 11.4 6.4 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF913 PF06025.12 CDI74445.1 - 0.25 10.3 6.0 0.27 10.2 6.0 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CobT PF06213.12 CDI74445.1 - 0.3 10.4 23.0 0.32 10.3 23.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 CDI74445.1 - 0.4 8.7 31.9 0.46 8.5 31.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi RXT2_N PF08595.11 CDI74445.1 - 0.45 10.5 12.3 0.58 10.2 12.3 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal EIIBC-GUT_N PF03612.14 CDI74445.1 - 0.53 10.0 5.7 0.58 9.9 5.7 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF5523 PF17661.1 CDI74445.1 - 0.58 9.8 20.5 0.62 9.7 20.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) RAB3GAP2_C PF14656.6 CDI74445.1 - 0.67 8.1 8.9 0.74 8.0 8.9 1.0 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus Nop53 PF07767.11 CDI74445.1 - 0.69 9.2 21.8 0.74 9.1 21.8 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF719 PF05334.13 CDI74445.1 - 0.72 10.0 9.2 0.73 10.0 9.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF719) DUF4820 PF16091.5 CDI74445.1 - 0.73 9.2 11.8 0.82 9.0 11.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) ORC_WH_C PF18137.1 CDI74445.1 - 0.95 9.5 11.1 1.1 9.4 11.1 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal TRAP_alpha PF03896.16 CDI74445.1 - 0.98 8.6 16.2 1 8.5 16.2 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PPL5 PF18168.1 CDI74445.1 - 1 8.6 5.4 1.1 8.5 5.4 1.0 1 0 0 1 1 1 0 Prim-pol family 5 V_ATPase_I PF01496.19 CDI74445.1 - 1.1 7.1 8.5 0.98 7.2 8.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPR3 PF03666.13 CDI74445.1 - 1.1 7.9 6.1 1.2 7.8 6.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2052 PF09747.9 CDI74445.1 - 1.2 9.2 22.4 1.8 8.7 22.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) dsRBD2 PF17842.1 CDI74445.1 - 1.3 9.2 4.5 1.3 9.2 4.5 1.1 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 ATP-synt_E PF05680.12 CDI74445.1 - 1.5 9.2 11.7 1.8 9.0 11.7 1.1 1 0 0 1 1 1 0 ATP synthase E chain DUF3464 PF11947.8 CDI74445.1 - 1.6 8.5 4.6 1.7 8.3 4.6 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 SpoIIP PF07454.11 CDI74445.1 - 1.6 8.1 11.8 1.6 8.1 11.8 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Prothymosin PF03247.14 CDI74445.1 - 1.6 9.2 39.3 2.2 8.8 39.3 1.2 1 0 0 1 1 1 0 Prothymosin/parathymosin family CTU2 PF10288.9 CDI74445.1 - 1.8 8.8 7.4 2.2 8.5 7.4 1.1 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 GNAT_acetyltr_2 PF13718.6 CDI74445.1 - 1.8 7.9 5.3 1.8 7.9 5.3 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 TMEM51 PF15345.6 CDI74445.1 - 2 8.2 5.3 2.1 8.1 5.3 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Folate_carrier PF01770.18 CDI74445.1 - 2.2 6.9 3.0 2.1 7.0 3.0 1.0 1 0 0 1 1 1 0 Reduced folate carrier RPN2_C PF18004.1 CDI74445.1 - 2.4 8.0 17.2 2.7 7.9 17.2 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Vfa1 PF08432.10 CDI74445.1 - 2.4 8.4 12.4 2.6 8.3 12.4 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Zip PF02535.22 CDI74445.1 - 2.6 7.2 7.9 2.9 7.0 7.9 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter SspB PF04386.13 CDI74445.1 - 2.7 7.8 12.2 3 7.7 12.2 1.0 1 0 0 1 1 1 0 Stringent starvation protein B Mpp10 PF04006.12 CDI74445.1 - 2.8 6.3 26.2 3.1 6.1 26.2 1.0 1 0 0 1 1 1 0 Mpp10 protein Paf1 PF03985.13 CDI74445.1 - 2.9 6.8 27.3 3 6.7 27.3 1.0 1 0 0 1 1 1 0 Paf1 Nop14 PF04147.12 CDI74445.1 - 2.9 6.0 27.6 3.1 5.9 27.6 1.0 1 0 0 1 1 1 0 Nop14-like family TFB6 PF17110.5 CDI74445.1 - 3 7.6 12.6 3.3 7.4 12.6 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH MRNIP PF15749.5 CDI74445.1 - 3.1 8.5 10.8 3.9 8.3 10.8 1.1 1 0 0 1 1 1 0 MRN-interacting protein XAP5 PF04921.14 CDI74445.1 - 3.2 7.5 13.5 3.6 7.3 13.5 1.0 1 0 0 1 1 1 0 XAP5, circadian clock regulator DUF4471 PF14740.6 CDI74445.1 - 3.4 6.8 7.3 3.3 6.8 7.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) Sec62 PF03839.16 CDI74445.1 - 3.5 7.1 4.9 3.9 6.9 4.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DDHD PF02862.17 CDI74445.1 - 3.6 7.7 5.0 3.5 7.7 5.0 1.0 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 CDI74445.1 - 3.8 6.2 8.8 3.9 6.1 8.8 1.0 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI74445.1 - 3.9 7.2 16.5 4.2 7.1 16.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2457 PF10446.9 CDI74445.1 - 4.1 6.4 31.5 4.4 6.3 31.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RNA_pol_Rpc4 PF05132.14 CDI74445.1 - 4.4 7.7 9.5 5 7.6 9.5 1.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 Usp PF00582.26 CDI74445.1 - 4.9 7.7 10.3 5.4 7.5 10.3 1.1 1 0 0 1 1 1 0 Universal stress protein family DUF2428 PF10350.9 CDI74445.1 - 5.2 6.2 7.6 5.1 6.3 7.6 1.0 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) DARPP-32 PF05395.12 CDI74445.1 - 5.3 7.2 21.6 5.9 7.1 21.6 1.0 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 AIF_C PF14721.6 CDI74445.1 - 5.5 7.4 7.1 6 7.2 7.1 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Sigma70_ner PF04546.13 CDI74445.1 - 5.7 6.8 21.7 6.5 6.6 21.7 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region CLN3 PF02487.17 CDI74445.1 - 7 5.6 4.5 7.4 5.5 4.5 1.0 1 0 0 1 1 1 0 CLN3 protein Tim54 PF11711.8 CDI74445.1 - 7.1 5.3 14.6 8.2 5.1 14.6 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NOA36 PF06524.12 CDI74445.1 - 7.2 5.8 23.5 8.4 5.6 23.5 1.1 1 0 0 1 1 1 0 NOA36 protein DUF4746 PF15928.5 CDI74445.1 - 7.6 5.9 22.7 11 5.4 22.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Ureide_permease PF07168.11 CDI74445.1 - 7.7 5.2 4.6 8.1 5.1 4.6 1.0 1 0 0 1 1 1 0 Ureide permease DUF3306 PF11748.8 CDI74445.1 - 8.8 7.2 12.5 10 7.0 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) CDC45 PF02724.14 CDI74446.1 - 9.6 4.4 20.0 12 4.0 20.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Rtf2 PF04641.12 CDI74447.1 - 0.26 10.6 21.8 0.28 10.5 21.8 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2052 PF09747.9 CDI74447.1 - 1.7 8.8 24.9 1.8 8.7 24.9 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4746 PF15928.5 CDI74447.1 - 2.4 7.5 19.2 2.6 7.4 19.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RR_TM4-6 PF06459.12 CDI74447.1 - 4 7.2 28.1 4.5 7.0 28.1 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM76 PF16046.5 CDI74447.1 - 6.2 6.1 30.8 8.5 5.6 30.8 1.3 1 0 0 1 1 1 0 FAM76 protein RRP36 PF06102.12 CDI74447.1 - 7.3 6.5 28.5 12 5.8 28.5 1.4 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 CDC45 PF02724.14 CDI74447.1 - 7.6 4.7 22.8 8.4 4.5 22.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI74447.1 - 8.8 5.0 33.8 10 4.8 33.8 1.0 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 CDI74447.1 - 9 5.0 25.1 10 4.7 25.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Tim54 PF11711.8 CDI74447.1 - 9.8 4.8 22.3 12 4.6 22.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SprA-related PF12118.8 CDI74448.1 - 0.092 11.9 21.0 0.13 11.4 21.0 1.2 1 0 0 1 1 1 0 SprA-related family RskA PF10099.9 CDI74448.1 - 0.12 12.6 21.7 0.23 11.7 21.7 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA CD20 PF04103.15 CDI74448.1 - 0.16 12.1 3.7 0.35 10.9 0.3 2.1 2 0 0 2 2 2 0 CD20-like family TFIIA PF03153.13 CDI74448.1 - 0.42 10.6 24.1 0.49 10.3 24.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF5585 PF17823.1 CDI74448.1 - 0.62 8.9 23.0 0.8 8.6 23.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Miga PF10265.9 CDI74448.1 - 1.4 7.8 11.4 1.6 7.6 11.4 1.0 1 0 0 1 1 1 0 Mitoguardin Presenilin PF01080.17 CDI74448.1 - 3.8 6.2 10.6 4.5 5.9 10.6 1.1 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 CDI74448.1 - 4 6.4 8.4 5 6.1 8.4 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Dala_Dala_lig_N PF01820.21 CDI74450.1 - 4.1 7.9 12.3 2.9e+02 2.0 10.8 2.7 1 1 1 2 2 2 0 D-ala D-ala ligase N-terminus RskA PF10099.9 CDI74450.1 - 8.2 6.7 52.0 0.049 13.9 13.8 3.2 1 1 2 3 3 3 0 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI74450.1 - 9.7 7.2 39.6 0.89 10.6 8.1 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) N6_N4_Mtase PF01555.18 CDI74451.1 - 0.0019 18.0 0.0 0.14 11.9 0.0 2.8 1 1 0 1 1 1 1 DNA methylase Patatin PF01734.22 CDI74451.1 - 0.0053 17.0 0.4 26 4.9 0.0 2.5 2 1 0 2 2 2 0 Patatin-like phospholipase Vfa1 PF08432.10 CDI74451.1 - 0.02 15.2 46.3 0.81 10.0 37.7 3.2 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 TctB PF07331.11 CDI74451.1 - 0.024 14.9 2.7 22 5.3 7.9 2.7 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter TctB family Lin-8 PF03353.15 CDI74451.1 - 0.033 13.8 54.8 0.15 11.6 39.8 2.5 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist CCSAP PF15748.5 CDI74451.1 - 0.06 13.5 60.7 0.38 10.9 8.8 2.4 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated AAA_11 PF13086.6 CDI74451.1 - 0.12 12.1 40.2 0.18 11.6 30.6 2.3 2 0 0 2 2 2 0 AAA domain RIFIN PF02009.16 CDI74451.1 - 6.4 6.6 41.5 0.41 10.5 9.2 2.4 2 0 0 2 2 2 0 Rifin DUF2722 PF10846.8 CDI74453.1 - 0.001 18.1 3.9 0.001 18.1 3.9 7.3 5 2 1 6 6 6 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI74453.1 - 0.0021 18.3 3.5 0.0021 18.3 3.5 11.5 3 3 7 10 10 10 1 Anti-sigma-K factor rskA DUF4366 PF14283.6 CDI74454.1 - 0.47 10.5 13.7 0.15 12.1 1.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) DUF4228 PF14009.6 CDI74454.1 - 2 8.8 12.9 0.64 10.4 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) STE3 PF02076.15 CDI74454.1 - 2.4 7.3 5.7 3.6 6.7 5.7 1.3 1 0 0 1 1 1 0 Pheromone A receptor Rtf2 PF04641.12 CDI74454.1 - 4.7 6.5 22.0 2.4 7.4 6.8 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger FHIPEP PF00771.20 CDI74454.1 - 7.3 4.9 23.2 0.22 9.9 9.7 2.1 2 0 0 2 2 2 0 FHIPEP family DUF4407 PF14362.6 CDI74454.1 - 8.5 5.6 34.5 15 4.8 34.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FATC PF02260.20 CDI74455.1 - 3.9e-11 42.6 0.0 1.2e-10 41.0 0.0 1.9 1 0 0 1 1 1 1 FATC domain DUF4964 PF16334.5 CDI74455.1 - 0.014 14.9 0.4 0.15 11.6 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4964) SARAF PF06682.12 CDI74455.1 - 0.19 11.3 65.4 0.42 10.2 5.4 6.6 5 1 0 5 5 5 0 SOCE-associated regulatory factor of calcium homoeostasis FBPase PF00316.20 CDI74457.1 - 3.3e-47 160.4 1.9 3.3e-41 140.9 0.4 2.1 1 1 1 2 2 2 2 Fructose-1-6-bisphosphatase, N-terminal domain zf-CCHC PF00098.23 CDI74458.1 - 1.1e-07 31.6 8.2 0.0022 18.0 0.5 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 CDI74458.1 - 0.00039 20.2 4.1 0.031 14.1 0.2 3.0 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 CDI74458.1 - 0.0055 16.4 3.7 0.71 9.7 0.5 2.6 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 CDI74458.1 - 0.66 9.9 6.1 8.2 6.4 1.3 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 CDI74458.1 - 1.3 9.1 10.3 3 7.9 0.4 3.7 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_5 PF14787.6 CDI74458.1 - 1.7 8.4 6.4 2.5 7.9 1.3 2.7 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger OrfB_Zn_ribbon PF07282.11 CDI74458.1 - 4.1 7.4 5.2 5.1 7.1 1.1 3.0 2 1 1 3 3 3 0 Putative transposase DNA-binding domain BAF1_ABF1 PF04684.13 CDI74460.1 - 0.00074 18.7 20.8 0.00076 18.7 20.8 1.0 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor FAM76 PF16046.5 CDI74460.1 - 0.091 12.1 26.3 0.1 12.0 26.3 1.1 1 0 0 1 1 1 0 FAM76 protein Presenilin PF01080.17 CDI74460.1 - 0.096 11.4 35.1 0.1 11.4 35.1 1.0 1 0 0 1 1 1 0 Presenilin DUF3807 PF12720.7 CDI74460.1 - 0.1 12.9 35.2 0.12 12.6 35.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) NST1 PF13945.6 CDI74460.1 - 0.1 12.7 37.7 0.13 12.4 37.7 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Mcm10 PF09332.11 CDI74460.1 - 0.18 11.2 33.5 0.24 10.8 33.5 1.1 1 0 0 1 1 1 0 Mcm10 replication factor Slu7 PF11708.8 CDI74460.1 - 0.24 11.1 26.3 0.35 10.6 26.3 1.3 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor SLC12 PF03522.15 CDI74460.1 - 0.28 10.2 29.4 0.29 10.1 29.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF2052 PF09747.9 CDI74460.1 - 0.36 10.9 28.2 0.4 10.8 28.2 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) AAA_11 PF13086.6 CDI74460.1 - 0.41 10.4 26.0 0.42 10.3 26.0 1.0 1 0 0 1 1 1 0 AAA domain CDC45 PF02724.14 CDI74460.1 - 0.61 8.3 25.7 0.63 8.3 25.7 1.0 1 0 0 1 1 1 0 CDC45-like protein MDM10 PF12519.8 CDI74460.1 - 0.62 8.9 23.4 0.61 8.9 23.4 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SRP-alpha_N PF04086.13 CDI74460.1 - 0.67 9.8 27.5 0.7 9.8 27.5 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal PPL5 PF18168.1 CDI74460.1 - 0.77 9.0 19.9 0.92 8.7 19.9 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF2151 PF10221.9 CDI74460.1 - 0.9 8.1 15.3 0.93 8.0 15.3 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Spem1 PF15670.5 CDI74460.1 - 0.92 9.0 23.4 1.3 8.6 23.4 1.3 1 0 0 1 1 1 0 Spermatid maturation protein 1 DUF4045 PF13254.6 CDI74460.1 - 1 8.9 27.2 1.2 8.7 27.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Gti1_Pac2 PF09729.9 CDI74460.1 - 1.1 9.4 25.7 1.3 9.1 25.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family AF-4 PF05110.13 CDI74460.1 - 1.1 7.3 32.6 1.2 7.1 32.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Apt1 PF10351.9 CDI74460.1 - 1.3 7.8 18.8 1.3 7.8 18.8 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Tim54 PF11711.8 CDI74460.1 - 1.3 7.8 26.5 1.5 7.5 26.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NPR3 PF03666.13 CDI74460.1 - 1.3 7.7 28.0 1.5 7.5 28.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TAF4 PF05236.14 CDI74460.1 - 1.4 8.6 30.9 1.6 8.4 30.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DUF2126 PF09899.9 CDI74460.1 - 1.4 6.9 22.1 1.6 6.7 22.1 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF4569 PF15133.6 CDI74460.1 - 1.6 8.4 29.4 1.7 8.3 29.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Neur_chan_memb PF02932.16 CDI74460.1 - 1.6 8.7 25.2 1.9 8.5 25.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MCM_bind PF09739.9 CDI74460.1 - 1.6 7.1 28.2 1.9 6.9 28.2 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Bul1_N PF04425.12 CDI74460.1 - 1.7 7.3 21.6 1.7 7.3 21.6 1.0 1 0 0 1 1 1 0 Bul1 N terminus GREB1 PF15782.5 CDI74460.1 - 1.7 5.7 31.1 1.8 5.6 31.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Cellulose_synt PF03552.14 CDI74460.1 - 1.7 7.0 11.8 1.7 7.1 11.8 1.0 1 0 0 1 1 1 0 Cellulose synthase Endostatin PF06482.11 CDI74460.1 - 2.1 7.7 27.9 2.4 7.6 27.9 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF4366 PF14283.6 CDI74460.1 - 2.2 8.3 16.0 3.2 7.8 16.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) CCSAP PF15748.5 CDI74460.1 - 2.5 8.2 34.9 2.8 8.1 34.9 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Band_3_cyto PF07565.13 CDI74460.1 - 2.5 7.9 26.5 3.8 7.3 26.5 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain eIF-3_zeta PF05091.12 CDI74460.1 - 2.6 6.9 38.3 3.6 6.5 38.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Vac7 PF12751.7 CDI74460.1 - 2.7 7.3 16.5 3.3 7.0 16.5 1.0 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 CAF1 PF04857.20 CDI74460.1 - 3.1 6.9 21.3 3.2 6.9 21.3 1.0 1 0 0 1 1 1 0 CAF1 family ribonuclease CobT PF06213.12 CDI74460.1 - 3.2 7.1 42.8 4.7 6.5 42.8 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF1387 PF07139.11 CDI74460.1 - 3.3 7.4 28.3 3.7 7.2 28.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) PAT1 PF09770.9 CDI74460.1 - 3.3 5.9 50.1 3.6 5.8 50.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TRAP_alpha PF03896.16 CDI74460.1 - 3.3 6.8 15.0 4 6.6 15.0 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit HGTP_anticodon2 PF12745.7 CDI74460.1 - 3.4 7.1 28.4 3.9 6.9 28.4 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Lin-8 PF03353.15 CDI74460.1 - 3.4 7.1 35.5 3.9 6.9 35.5 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4638 PF15472.6 CDI74460.1 - 3.4 7.3 25.2 3.9 7.1 25.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) ALMT PF11744.8 CDI74460.1 - 3.6 6.3 25.7 4.2 6.1 25.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3295 PF11702.8 CDI74460.1 - 3.8 6.8 29.6 4.2 6.6 29.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DUF4746 PF15928.5 CDI74460.1 - 3.8 6.9 23.0 5 6.5 23.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) NARP1 PF12569.8 CDI74460.1 - 4.1 6.2 28.3 5 5.9 28.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 PDDEXK_6 PF04720.12 CDI74460.1 - 4.7 7.1 19.4 5.6 6.8 19.4 1.1 1 0 0 1 1 1 0 PDDEXK-like family of unknown function DUF4207 PF13904.6 CDI74460.1 - 4.7 6.8 52.5 5.8 6.5 52.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) DUF4776 PF16003.5 CDI74460.1 - 5.7 5.8 27.0 6 5.7 27.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Raftlin PF15250.6 CDI74460.1 - 6.2 5.4 23.2 6.8 5.3 23.2 1.0 1 0 0 1 1 1 0 Raftlin SAPS PF04499.15 CDI74460.1 - 6.3 5.5 24.2 6.9 5.3 24.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein hDGE_amylase PF14701.6 CDI74460.1 - 6.3 5.8 16.4 6.6 5.7 16.4 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Membralin PF09746.9 CDI74460.1 - 6.7 5.6 21.5 7.8 5.4 21.5 1.0 1 0 0 1 1 1 0 Tumour-associated protein PA26 PF04636.13 CDI74460.1 - 6.9 5.5 24.2 7.8 5.3 24.2 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Hid1 PF12722.7 CDI74460.1 - 7 4.6 30.1 7.1 4.6 30.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein eIF3_subunit PF08597.10 CDI74460.1 - 7.7 6.3 31.8 9.6 6.0 31.8 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit UPF0565 PF10561.9 CDI74460.1 - 7.7 5.6 17.0 11 5.2 17.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Afi1 PF07792.12 CDI74460.1 - 9.1 6.8 27.5 14 6.2 27.5 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CLN3 PF02487.17 CDI74460.1 - 9.4 5.2 25.6 10 5.0 25.6 1.1 1 0 0 1 1 1 0 CLN3 protein PNISR PF15996.5 CDI74460.1 - 9.6 6.4 36.1 12 6.1 36.1 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Orf78 PF06024.12 CDI74461.1 - 0.015 15.6 2.8 0.017 15.4 2.8 1.1 1 0 0 1 1 1 0 Orf78 (ac78) SelP_N PF04592.14 CDI74461.1 - 0.047 13.1 28.4 0.048 13.1 28.4 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region eIF3_subunit PF08597.10 CDI74461.1 - 0.25 11.2 6.1 0.27 11.1 6.1 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF3405 PF11885.8 CDI74461.1 - 0.56 8.8 12.2 0.56 8.7 12.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) FAM176 PF14851.6 CDI74461.1 - 0.63 9.7 5.5 0.7 9.6 5.5 1.2 1 0 0 1 1 1 0 FAM176 family DUF3347 PF11827.8 CDI74461.1 - 0.63 10.2 13.8 0.76 9.9 13.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) TFB6 PF17110.5 CDI74461.1 - 0.75 9.5 5.5 0.78 9.5 5.5 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Peptidase_S49_N PF08496.10 CDI74461.1 - 0.81 9.7 8.8 0.86 9.7 8.8 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MDFI PF15316.6 CDI74461.1 - 0.93 9.6 9.5 0.95 9.5 9.5 1.0 1 0 0 1 1 1 0 MyoD family inhibitor Connexin PF00029.19 CDI74461.1 - 1.1 9.0 11.2 1.2 8.8 11.2 1.1 1 0 0 1 1 1 0 Connexin TMEM51 PF15345.6 CDI74461.1 - 1.1 9.1 12.6 1.3 8.8 12.6 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Rpp20 PF12328.8 CDI74461.1 - 1.1 9.2 6.5 1.3 8.9 6.5 1.2 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P CPSF100_C PF13299.6 CDI74461.1 - 1.2 9.3 7.5 1.3 9.2 7.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 CDI74461.1 - 1.3 7.7 12.6 1.4 7.6 12.6 1.0 1 0 0 1 1 1 0 Presenilin EIIBC-GUT_N PF03612.14 CDI74461.1 - 1.5 8.5 9.6 1.5 8.5 9.6 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus MDM31_MDM32 PF08118.11 CDI74461.1 - 1.5 7.4 9.5 1.6 7.3 9.5 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins EOS1 PF12326.8 CDI74461.1 - 1.6 8.6 6.2 1.6 8.6 6.2 1.1 1 0 0 1 1 1 0 N-glycosylation protein DUF3464 PF11947.8 CDI74461.1 - 1.6 8.4 8.2 2 8.2 8.2 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Pex14_N PF04695.13 CDI74461.1 - 1.7 9.3 17.6 1.7 9.3 17.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region V_ATPase_I PF01496.19 CDI74461.1 - 2.1 6.2 14.7 2 6.3 14.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CobT PF06213.12 CDI74461.1 - 2.1 7.7 14.3 2.2 7.6 14.3 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Kei1 PF08552.11 CDI74461.1 - 2.6 7.9 6.0 2.4 8.0 6.0 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Folate_carrier PF01770.18 CDI74461.1 - 3.1 6.4 6.5 3.3 6.3 6.5 1.0 1 0 0 1 1 1 0 Reduced folate carrier Neur_chan_memb PF02932.16 CDI74461.1 - 3.7 7.5 9.7 3.6 7.6 9.7 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region eIF-3_zeta PF05091.12 CDI74461.1 - 4.2 6.2 14.1 4.4 6.2 14.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MDM10 PF12519.8 CDI74461.1 - 4.2 6.1 9.0 4.2 6.1 9.0 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Ctr PF04145.15 CDI74461.1 - 4.3 7.9 6.7 4.6 7.9 6.7 1.1 1 0 0 1 1 1 0 Ctr copper transporter family ALMT PF11744.8 CDI74461.1 - 5 5.8 10.4 5.5 5.7 10.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CLN3 PF02487.17 CDI74461.1 - 5.1 6.0 9.2 5.7 5.9 9.2 1.0 1 0 0 1 1 1 0 CLN3 protein CSG2 PF16965.5 CDI74461.1 - 6.1 5.7 5.9 5.5 5.8 5.9 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator MMR1 PF08505.10 CDI74461.1 - 6.3 7.0 16.7 6.5 7.0 16.7 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein AF-4 PF05110.13 CDI74461.1 - 8.6 4.3 19.0 8.7 4.3 19.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF2367 PF10164.9 CDI74461.1 - 8.8 6.9 7.8 12 6.5 7.8 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) Spt20 PF12090.8 CDI74462.1 - 0.0057 16.3 35.7 0.0073 15.9 35.7 1.1 1 0 0 1 1 1 1 Spt20 family MDM1 PF15501.6 CDI74462.1 - 0.012 14.9 19.1 0.014 14.6 19.1 1.0 1 0 0 1 1 1 0 Nuclear protein MDM1 ALMT PF11744.8 CDI74462.1 - 0.014 14.2 11.8 0.015 14.2 11.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter EPL1 PF10513.9 CDI74462.1 - 0.017 15.5 17.6 0.02 15.3 17.6 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF4820 PF16091.5 CDI74462.1 - 0.021 14.2 15.3 0.031 13.7 15.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Tim54 PF11711.8 CDI74462.1 - 0.038 12.8 15.9 0.041 12.7 15.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TMEM51 PF15345.6 CDI74462.1 - 0.043 13.7 17.8 0.054 13.3 17.8 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 DUF3807 PF12720.7 CDI74462.1 - 0.044 14.1 23.3 0.047 14.0 23.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Pex14_N PF04695.13 CDI74462.1 - 0.056 14.1 16.4 0.075 13.7 16.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region BAF1_ABF1 PF04684.13 CDI74462.1 - 0.067 12.3 23.0 0.08 12.0 23.0 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor MMR1 PF08505.10 CDI74462.1 - 0.071 13.4 19.2 0.076 13.3 19.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein TFIIA PF03153.13 CDI74462.1 - 0.085 12.8 29.9 0.096 12.7 29.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2052 PF09747.9 CDI74462.1 - 0.086 13.0 23.4 0.1 12.7 23.4 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Asparaginase_2 PF01112.18 CDI74462.1 - 0.099 11.6 9.6 0.12 11.4 9.6 1.2 1 0 0 1 1 1 0 Asparaginase FAM220 PF15487.6 CDI74462.1 - 0.1 12.2 9.4 0.11 12.1 9.4 1.0 1 0 0 1 1 1 0 FAM220 family NST1 PF13945.6 CDI74462.1 - 0.11 12.6 24.5 0.14 12.3 24.5 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Sporozoite_P67 PF05642.11 CDI74462.1 - 0.13 10.3 10.0 0.15 10.1 10.0 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SpoIIP PF07454.11 CDI74462.1 - 0.13 11.7 18.7 0.15 11.5 18.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) ESM4 PF15952.5 CDI74462.1 - 0.14 12.6 22.2 0.17 12.3 22.2 1.2 1 0 0 1 1 1 0 Enhancer of split M4 family DUF702 PF05142.12 CDI74462.1 - 0.14 12.6 15.7 0.18 12.3 15.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF702) TERB2 PF15101.6 CDI74462.1 - 0.14 12.2 16.8 0.16 12.0 16.8 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SLC12 PF03522.15 CDI74462.1 - 0.22 10.5 18.7 0.24 10.4 18.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 VIT1 PF01988.19 CDI74462.1 - 0.22 11.3 10.0 0.27 11.1 10.0 1.1 1 0 0 1 1 1 0 VIT family DUF4647 PF15504.6 CDI74462.1 - 0.28 10.2 18.1 0.3 10.1 18.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) SET PF00856.28 CDI74462.1 - 0.29 11.5 5.2 0.35 11.2 5.2 1.2 1 0 0 1 1 1 0 SET domain DUF4471 PF14740.6 CDI74462.1 - 0.29 10.3 11.5 0.31 10.2 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) DUF3523 PF12037.8 CDI74462.1 - 0.31 10.4 25.1 0.35 10.2 25.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) Ndc1_Nup PF09531.10 CDI74462.1 - 0.34 9.6 14.7 0.36 9.5 14.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PTPRCAP PF15713.5 CDI74462.1 - 0.36 11.1 19.1 0.5 10.6 19.1 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CCSAP PF15748.5 CDI74462.1 - 0.37 10.9 22.4 0.44 10.7 22.4 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated ABC2_membrane_2 PF12679.7 CDI74462.1 - 0.38 10.0 2.3 0.49 9.6 2.3 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Bud13 PF09736.9 CDI74462.1 - 0.39 11.1 20.5 0.48 10.8 20.5 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex DDHD PF02862.17 CDI74462.1 - 0.39 10.8 14.3 0.46 10.6 14.3 1.2 1 0 0 1 1 1 0 DDHD domain CNDH2_M PF16869.5 CDI74462.1 - 0.4 11.4 13.3 0.51 11.0 13.3 1.1 1 0 0 1 1 1 0 PF16858 DUF3340 PF11818.8 CDI74462.1 - 0.63 10.2 22.4 0.78 9.9 22.4 1.1 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) DUF4746 PF15928.5 CDI74462.1 - 0.64 9.4 16.7 0.71 9.2 16.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Band_3_cyto PF07565.13 CDI74462.1 - 0.72 9.6 15.7 0.86 9.4 15.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain D123 PF07065.14 CDI74462.1 - 0.77 8.9 11.6 0.89 8.7 11.6 1.1 1 0 0 1 1 1 0 D123 Otopetrin PF03189.13 CDI74462.1 - 0.81 8.4 7.9 0.82 8.4 7.9 1.1 1 0 0 1 1 1 0 Otopetrin HNOBA PF07701.14 CDI74462.1 - 0.82 9.1 11.3 0.95 8.9 11.3 1.3 1 0 0 1 1 1 0 Heme NO binding associated UPF0560 PF10577.9 CDI74462.1 - 0.89 8.0 15.4 0.97 7.9 15.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Vfa1 PF08432.10 CDI74462.1 - 0.91 9.8 21.7 1.1 9.5 21.7 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Es2 PF09751.9 CDI74462.1 - 0.99 9.1 22.4 1.2 8.8 22.4 1.0 1 0 0 1 1 1 0 Nuclear protein Es2 DUF2126 PF09899.9 CDI74462.1 - 1 7.4 11.9 1.2 7.2 11.9 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) ETAA1 PF15350.6 CDI74462.1 - 1.1 7.5 24.8 1.3 7.2 24.8 1.1 1 0 0 1 1 1 0 Ewing's tumour-associated antigen 1 homologue CPSF100_C PF13299.6 CDI74462.1 - 1.2 9.3 17.8 1.7 8.8 17.8 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Dapper PF15268.6 CDI74462.1 - 1.3 7.8 18.8 1.4 7.6 18.8 1.0 1 0 0 1 1 1 0 Dapper DDRGK PF09756.9 CDI74462.1 - 1.4 8.5 28.7 1.6 8.2 28.7 1.1 1 0 0 1 1 1 0 DDRGK domain Paf1 PF03985.13 CDI74462.1 - 1.4 7.8 21.5 1.5 7.7 21.5 1.1 1 0 0 1 1 1 0 Paf1 DUF913 PF06025.12 CDI74462.1 - 1.4 7.8 14.1 1.6 7.6 14.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) GREB1 PF15782.5 CDI74462.1 - 1.4 5.9 14.9 1.6 5.7 14.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer YABBY PF04690.13 CDI74462.1 - 1.4 9.4 13.0 1.7 9.2 13.0 1.2 1 0 0 1 1 1 0 YABBY protein SAPS PF04499.15 CDI74462.1 - 1.5 7.5 15.5 1.6 7.4 15.5 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 CDI74462.1 - 1.5 7.0 17.4 1.6 6.9 17.4 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.6 CDI74462.1 - 1.6 8.6 14.1 2.1 8.3 14.1 1.2 1 0 0 1 1 1 0 Protein Family FAM60A PIEZO PF15917.5 CDI74462.1 - 1.7 8.1 17.8 2.1 7.8 17.8 1.3 1 0 0 1 1 1 0 Piezo Baculo_PP31 PF05311.11 CDI74462.1 - 1.7 8.1 18.7 2 7.9 18.7 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) PPL5 PF18168.1 CDI74462.1 - 1.9 7.7 15.0 2.2 7.5 15.0 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Folate_carrier PF01770.18 CDI74462.1 - 2.3 6.9 9.1 2.5 6.7 9.1 1.2 1 0 0 1 1 1 0 Reduced folate carrier PA26 PF04636.13 CDI74462.1 - 2.3 7.1 11.7 2.6 6.9 11.7 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Pet20 PF08692.10 CDI74462.1 - 2.8 8.7 10.0 3.6 8.3 10.0 1.2 1 0 0 1 1 1 0 Mitochondrial protein Pet20 Membralin PF09746.9 CDI74462.1 - 2.8 6.9 13.1 3.2 6.7 13.1 1.0 1 0 0 1 1 1 0 Tumour-associated protein TRAP_alpha PF03896.16 CDI74462.1 - 2.9 7.0 12.6 3.6 6.7 12.6 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit MCM_bind PF09739.9 CDI74462.1 - 3.2 6.1 17.4 3.7 5.9 17.4 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF1523 PF07509.11 CDI74462.1 - 3.6 6.9 4.7 4.6 6.6 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) Endostatin PF06482.11 CDI74462.1 - 3.6 6.9 14.2 4.1 6.8 14.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin RR_TM4-6 PF06459.12 CDI74462.1 - 3.7 7.3 23.9 4.3 7.1 23.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CSRNP_N PF16019.5 CDI74462.1 - 3.9 7.3 16.1 4.9 7.0 16.1 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Peptidase_S64 PF08192.11 CDI74462.1 - 4 5.8 14.4 4 5.8 14.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 Hid1 PF12722.7 CDI74462.1 - 4 5.4 17.3 4.5 5.3 17.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PAT1 PF09770.9 CDI74462.1 - 4.1 5.5 24.7 4.7 5.4 24.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Sec62 PF03839.16 CDI74462.1 - 4.3 6.8 18.0 5.1 6.5 18.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 NPR3 PF03666.13 CDI74462.1 - 4.5 6.0 20.4 5.2 5.7 20.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2828 PF11443.8 CDI74462.1 - 4.5 5.2 19.9 5.5 5.0 19.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Connexin PF00029.19 CDI74462.1 - 4.6 6.9 15.5 5.4 6.7 15.5 1.2 1 0 0 1 1 1 0 Connexin Atg14 PF10186.9 CDI74462.1 - 4.8 6.2 19.6 5.2 6.1 19.6 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Presenilin PF01080.17 CDI74462.1 - 4.8 5.8 23.4 5.5 5.7 23.4 1.0 1 0 0 1 1 1 0 Presenilin DUF2151 PF10221.9 CDI74462.1 - 5.3 5.5 15.6 5.9 5.4 15.6 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Neur_chan_memb PF02932.16 CDI74462.1 - 5.3 7.0 16.0 5.8 6.9 16.0 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Gti1_Pac2 PF09729.9 CDI74462.1 - 5.3 7.1 16.6 6.4 6.8 16.6 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Folliculin PF11704.8 CDI74462.1 - 6 6.7 11.9 7.3 6.4 11.9 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Scs3p PF10261.9 CDI74462.1 - 6.3 6.2 5.6 7.3 6.0 5.6 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM SprA-related PF12118.8 CDI74462.1 - 6.5 5.8 31.4 8.5 5.4 31.4 1.1 1 0 0 1 1 1 0 SprA-related family eIF-3_zeta PF05091.12 CDI74462.1 - 7.4 5.4 23.4 8.8 5.2 23.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF1980 PF09323.10 CDI74462.1 - 7.6 6.4 13.1 8.9 6.2 13.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Afi1 PF07792.12 CDI74462.1 - 7.6 7.0 19.7 10 6.6 19.7 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CLN3 PF02487.17 CDI74462.1 - 8.1 5.4 15.6 9.5 5.1 15.6 1.1 1 0 0 1 1 1 0 CLN3 protein Rtf2 PF04641.12 CDI74462.1 - 8.1 5.7 21.0 11 5.2 21.0 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger FAM150 PF15129.6 CDI74462.1 - 8.8 6.5 14.5 12 6.1 14.5 1.3 1 0 0 1 1 1 0 FAM150 family Med19 PF10278.9 CDI74462.1 - 8.8 6.2 19.5 10 6.0 19.5 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 V_ATPase_I PF01496.19 CDI74462.1 - 8.9 4.1 21.7 11 3.8 21.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PFK PF00365.20 CDI74463.1 - 3.3e-55 187.4 0.0 1.6e-33 116.3 0.0 3.5 2 1 0 2 2 2 2 Phosphofructokinase GYF PF02213.16 CDI74463.1 - 2.9e-10 39.6 6.7 3.9e-10 39.2 5.1 2.1 2 0 0 2 2 2 1 GYF domain Hydrolase_3 PF08282.12 CDI74464.1 - 3.2e-43 148.3 0.0 4e-43 148.0 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDI74464.1 - 5.4e-06 26.1 0.0 0.00016 21.3 0.0 2.1 2 0 0 2 2 2 1 Sucrose-6F-phosphate phosphohydrolase HAD_2 PF13419.6 CDI74464.1 - 0.2 11.7 0.0 1.9 8.6 0.0 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Oberon_cc PF16312.5 CDI74466.1 - 0.9 9.5 6.9 1.9 8.4 1.0 2.4 2 0 0 2 2 2 0 Coiled-coil region of Oberon Spt20 PF12090.8 CDI74468.1 - 0.0013 18.4 16.3 0.0015 18.2 16.3 1.2 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI74468.1 - 0.0057 15.7 12.5 0.0065 15.5 12.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DivIC PF04977.15 CDI74468.1 - 0.012 15.4 8.9 0.022 14.5 8.9 1.5 1 0 0 1 1 1 0 Septum formation initiator TFIIA PF03153.13 CDI74468.1 - 0.082 12.9 17.2 0.096 12.7 17.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Auts2 PF15336.6 CDI74468.1 - 0.085 13.0 2.2 0.097 12.8 2.2 1.1 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein PP_kinase_N PF13089.6 CDI74468.1 - 0.1 12.9 0.0 0.1 12.9 0.0 2.1 1 1 1 2 2 2 0 Polyphosphate kinase N-terminal domain LCD1 PF09798.9 CDI74468.1 - 0.14 10.7 6.0 0.13 10.7 6.0 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein BAF1_ABF1 PF04684.13 CDI74468.1 - 0.22 10.6 8.5 0.25 10.3 8.5 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4710 PF15828.5 CDI74468.1 - 0.3 11.3 3.0 0.65 10.2 3.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) MMR1 PF08505.10 CDI74468.1 - 0.48 10.7 9.0 0.57 10.4 9.0 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Ribosomal_60s PF00428.19 CDI74468.1 - 0.63 10.7 15.1 0.81 10.3 14.7 1.4 1 1 0 1 1 1 0 60s Acidic ribosomal protein CDK2AP PF09806.9 CDI74468.1 - 1.2 9.1 16.9 1.5 8.8 16.9 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Presenilin PF01080.17 CDI74468.1 - 2.5 6.8 7.1 2.9 6.6 7.1 1.1 1 0 0 1 1 1 0 Presenilin Senescence_reg PF04520.13 CDI74468.1 - 5 7.9 8.1 6.1 7.6 8.1 1.1 1 0 0 1 1 1 0 Senescence regulator Ndc1_Nup PF09531.10 CDI74468.1 - 7.2 5.2 9.2 7.5 5.1 9.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup UPF0016 PF01169.19 CDI74469.1 - 2.1e-18 66.4 2.4 2.5e-18 66.2 2.4 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0016 B12-binding PF02310.19 CDI74469.1 - 0.02 14.9 0.0 0.023 14.8 0.0 1.0 1 0 0 1 1 1 0 B12 binding domain RNase_H2_suC PF08615.11 CDI74470.1 - 1.6e-09 38.1 0.0 3.4e-09 37.0 0.0 1.5 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Peptidase_S24 PF00717.23 CDI74472.1 - 8.8e-08 32.0 0.0 1.3e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like OAD_gamma PF04277.13 CDI74473.1 - 0.56 10.8 0.0 0.56 10.8 0.0 2.7 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Rpp20 PF12328.8 CDI74477.1 - 0.0071 16.3 7.3 0.0071 16.3 7.3 4.7 3 1 0 3 3 3 2 Rpp20 subunit of nuclear RNase MRP and P Mucin PF01456.17 CDI74478.1 - 0.00035 20.6 4.2 0.00035 20.6 4.2 2.7 1 1 1 2 2 2 1 Mucin-like glycoprotein Herpes_UL74 PF07982.12 CDI74478.1 - 0.029 13.3 0.0 0.055 12.4 0.0 1.4 1 0 0 1 1 1 0 Herpes UL74 glycoproteins RskA PF10099.9 CDI74478.1 - 0.087 13.1 45.6 0.23 11.8 10.8 3.2 1 1 2 3 3 3 0 Anti-sigma-K factor rskA CD20 PF04103.15 CDI74478.1 - 0.31 11.1 0.0 0.31 11.1 0.0 2.7 2 1 1 3 3 3 0 CD20-like family DUF4834 PF16118.5 CDI74478.1 - 1.3 10.0 43.2 0.26 12.3 0.3 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI74478.1 - 4.4 6.9 96.6 0.19 11.3 16.5 3.1 3 0 0 3 3 3 0 Spt20 family Adeno_PIX PF03955.14 CDI74478.1 - 5.2 7.3 12.1 0.11 12.6 4.5 1.9 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) DUF755 PF05501.11 CDI74479.1 - 0.015 15.6 10.6 0.015 15.6 10.6 8.5 5 4 3 8 8 8 0 Domain of unknown function (DUF755) RskA PF10099.9 CDI74480.1 - 0.011 16.1 4.6 0.012 15.9 4.6 1.0 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI74481.1 - 5.7e-06 26.1 37.5 0.0053 16.4 15.9 3.4 3 0 0 3 3 3 2 Spt20 family RIFIN PF02009.16 CDI74481.1 - 0.0077 16.2 2.1 0.0077 16.2 2.1 5.3 3 2 2 5 5 5 1 Rifin RAB3GAP2_N PF14655.6 CDI74481.1 - 0.049 12.9 7.3 0.5 9.6 1.0 2.5 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus eIF-3_zeta PF05091.12 CDI74481.1 - 0.057 12.4 5.1 0.96 8.3 0.8 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF572 PF04502.13 CDI74481.1 - 0.057 13.0 5.9 0.13 11.9 0.5 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF572) DUF2722 PF10846.8 CDI74481.1 - 1.2 8.1 37.7 0.11 11.5 6.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) SARAF PF06682.12 CDI74481.1 - 1.4 8.4 19.4 0.79 9.3 7.5 3.1 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis LCD1 PF09798.9 CDI74481.1 - 2 6.8 4.6 9.2 4.6 0.1 2.1 2 0 0 2 2 2 0 DNA damage checkpoint protein SLC12 PF03522.15 CDI74481.1 - 2.8 6.9 6.1 16 4.4 4.6 2.2 2 0 0 2 2 2 0 Solute carrier family 12 Smg8_Smg9 PF10220.9 CDI74481.1 - 5.6 5.1 10.0 9.5 4.4 0.1 2.2 2 0 0 2 2 2 0 Smg8_Smg9 Spore_coat_CotO PF14153.6 CDI74483.1 - 0.088 12.7 38.4 0.12 12.3 38.4 1.3 1 0 0 1 1 1 0 Spore coat protein CotO DUF4366 PF14283.6 CDI74483.1 - 0.32 11.0 10.8 0.65 10.0 10.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) AAA_11 PF13086.6 CDI74483.1 - 0.63 9.8 25.8 0.71 9.6 25.8 1.1 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 CDI74483.1 - 1.3 7.7 33.0 1.4 7.6 33.0 1.2 1 0 0 1 1 1 0 Presenilin DUF5427 PF10310.9 CDI74483.1 - 1.7 7.5 30.8 1.9 7.3 30.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Cellulose_synt PF03552.14 CDI74483.1 - 1.8 6.9 11.7 2 6.8 11.7 1.0 1 0 0 1 1 1 0 Cellulose synthase CDC45 PF02724.14 CDI74483.1 - 3 6.0 25.3 3.4 5.9 25.3 1.0 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 CDI74483.1 - 3.1 6.5 26.1 3.2 6.4 26.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MCM_bind PF09739.9 CDI74483.1 - 4.1 5.7 25.8 4.5 5.6 25.8 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Peptidase_S64 PF08192.11 CDI74483.1 - 5 5.5 30.4 6.1 5.2 30.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 DDRGK PF09756.9 CDI74483.1 - 5.1 6.7 33.2 5.9 6.4 33.2 1.2 1 0 0 1 1 1 0 DDRGK domain ALMT PF11744.8 CDI74483.1 - 5.2 5.8 25.2 6 5.6 25.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CSG2 PF16965.5 CDI74483.1 - 5.7 5.8 12.4 7.1 5.5 12.4 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator eIF3_subunit PF08597.10 CDI74483.1 - 6.6 6.6 23.2 7.8 6.3 23.2 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Zip PF02535.22 CDI74483.1 - 7.4 5.7 27.5 8.2 5.5 27.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Velvet PF11754.8 CDI74483.1 - 7.5 6.4 27.7 9.4 6.1 27.7 1.3 1 0 0 1 1 1 0 Velvet factor Nucleoside_tran PF01733.18 CDI74483.1 - 8.2 5.7 7.5 13 5.1 7.5 1.4 1 0 0 1 1 1 0 Nucleoside transporter HCO3_cotransp PF00955.21 CDI74483.1 - 9 5.0 13.5 10 4.8 13.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family Lin-8 PF03353.15 CDI74483.1 - 9.3 5.7 39.7 11 5.5 39.7 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CCSAP PF15748.5 CDI74483.1 - 10 6.2 35.2 11 6.1 35.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SNF2_N PF00176.23 CDI74484.1 - 1.5e-64 217.9 1.0 1.5e-64 217.9 1.0 3.9 4 0 0 4 4 4 1 SNF2 family N-terminal domain AAA_25 PF13481.6 CDI74484.1 - 0.0054 16.3 0.7 0.2 11.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain Chromo PF00385.24 CDI74485.1 - 1.7e-10 40.7 0.0 2.4e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-CCHC PF00098.23 CDI74486.1 - 2.9e-06 27.1 7.5 0.0094 16.0 0.9 2.2 2 0 0 2 2 2 2 Zinc knuckle DnaJ_CXXCXGXG PF00684.19 CDI74486.1 - 0.016 15.6 1.6 0.027 14.8 1.6 1.3 1 0 0 1 1 1 0 DnaJ central domain zf-CCHC_6 PF15288.6 CDI74486.1 - 0.18 11.6 2.8 8.3 6.3 0.3 2.6 2 0 0 2 2 2 0 Zinc knuckle Sin_N PF04801.13 CDI74487.1 - 0.0046 16.2 0.1 0.0046 16.2 0.1 6.0 4 2 2 6 6 6 1 Sin-like protein conserved region mRNA_triPase PF02940.15 CDI74490.1 - 3.9e-05 23.5 1.7 0.002 17.9 0.0 2.8 3 0 0 3 3 3 1 mRNA capping enzyme, beta chain EPL1 PF10513.9 CDI74490.1 - 0.00035 21.0 1.0 0.00036 20.9 1.0 1.2 1 0 0 1 1 1 1 Enhancer of polycomb-like DDHD PF02862.17 CDI74490.1 - 0.00089 19.5 0.3 0.00089 19.5 0.3 1.1 1 0 0 1 1 1 1 DDHD domain Presenilin PF01080.17 CDI74490.1 - 0.0022 16.9 3.9 0.0024 16.7 3.9 1.1 1 0 0 1 1 1 1 Presenilin Gti1_Pac2 PF09729.9 CDI74490.1 - 0.0041 17.2 0.1 0.0041 17.2 0.1 1.2 1 0 0 1 1 1 1 Gti1/Pac2 family MDM10 PF12519.8 CDI74490.1 - 0.0094 14.9 0.7 0.0094 14.9 0.7 1.1 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 SpoIIP PF07454.11 CDI74490.1 - 0.02 14.3 7.9 0.029 13.8 7.9 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Ctr PF04145.15 CDI74490.1 - 0.072 13.7 0.1 0.072 13.7 0.1 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Otopetrin PF03189.13 CDI74490.1 - 0.098 11.5 0.5 0.11 11.3 0.5 1.1 1 0 0 1 1 1 0 Otopetrin Zip PF02535.22 CDI74490.1 - 0.17 11.1 0.2 0.15 11.3 0.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PepSY_TM PF03929.16 CDI74490.1 - 0.2 11.3 1.5 0.22 11.1 1.5 1.1 1 0 0 1 1 1 0 PepSY-associated TM region ABC2_membrane_2 PF12679.7 CDI74490.1 - 0.25 10.6 0.1 0.23 10.7 0.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein CPSF100_C PF13299.6 CDI74490.1 - 0.52 10.5 9.5 0.77 9.9 9.5 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal EOS1 PF12326.8 CDI74490.1 - 0.76 9.7 5.0 1.1 9.1 5.0 1.1 1 0 0 1 1 1 0 N-glycosylation protein TFIIA PF03153.13 CDI74490.1 - 0.83 9.6 32.8 1.2 9.1 32.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Isy1 PF06246.12 CDI74490.1 - 0.91 9.0 13.3 1.3 8.5 13.3 1.1 1 0 0 1 1 1 0 Isy1-like splicing family Eapp_C PF10238.9 CDI74490.1 - 1.3 9.1 14.5 2 8.5 14.5 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF3506 PF12014.8 CDI74490.1 - 1.5 8.8 6.0 2.4 8.2 6.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3506) RRP36 PF06102.12 CDI74490.1 - 1.6 8.7 16.9 2.5 8.1 16.9 1.2 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 Rxt3 PF08642.10 CDI74490.1 - 2 9.2 6.1 3.2 8.5 6.1 1.3 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 DUF4175 PF13779.6 CDI74490.1 - 2.6 5.8 29.1 3.3 5.5 29.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Pex14_N PF04695.13 CDI74490.1 - 3 8.5 21.7 4.4 7.9 21.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ATP-synt_E PF05680.12 CDI74490.1 - 3.3 8.1 13.0 6.5 7.2 13.0 1.5 1 0 0 1 1 1 0 ATP synthase E chain Ndc1_Nup PF09531.10 CDI74490.1 - 3.6 6.2 9.0 4.5 5.8 9.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Tim54 PF11711.8 CDI74490.1 - 4.9 5.8 11.5 6.8 5.4 11.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Peroxin-13_N PF04088.13 CDI74490.1 - 5.1 7.4 9.0 7.1 6.9 9.0 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Band_3_cyto PF07565.13 CDI74490.1 - 5.6 6.7 12.9 8.3 6.1 12.9 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SLC12 PF03522.15 CDI74490.1 - 6.4 5.7 12.3 9 5.2 12.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF3464 PF11947.8 CDI74490.1 - 7.5 6.3 13.7 11 5.8 13.7 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 PAT1 PF09770.9 CDI74490.1 - 7.7 4.6 22.4 10 4.3 22.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FAM176 PF14851.6 CDI74490.1 - 8.6 6.0 7.7 15 5.2 7.7 1.4 1 0 0 1 1 1 0 FAM176 family Peptidase_M22 PF00814.25 CDI74491.1 - 8.2e-22 78.2 7.2 1.2e-15 58.0 0.0 3.4 4 0 0 4 4 3 2 Glycoprotease family Hydin_ADK PF17213.3 CDI74491.1 - 1.3e-05 25.6 15.6 0.013 15.8 5.7 3.1 3 0 0 3 3 3 2 Hydin Adenylate kinase-like domain DUF2722 PF10846.8 CDI74491.1 - 0.00039 19.5 31.1 0.002 17.2 2.4 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF2722) DUF3464 PF11947.8 CDI74491.1 - 0.0041 16.9 0.4 0.0041 16.9 0.4 2.9 3 0 0 3 3 3 1 Photosynthesis affected mutant 68 DUF4834 PF16118.5 CDI74491.1 - 0.0056 17.6 18.1 0.3 12.1 2.5 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF4834) DUF3801 PF12687.7 CDI74491.1 - 0.0065 16.6 6.0 0.22 11.6 0.2 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3801) EPL1 PF10513.9 CDI74491.1 - 0.016 15.6 13.2 0.81 10.1 1.2 3.0 3 0 0 3 3 3 0 Enhancer of polycomb-like Neur_chan_memb PF02932.16 CDI74491.1 - 0.017 15.2 5.3 0.38 10.8 0.6 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF2828 PF11443.8 CDI74491.1 - 0.019 13.0 3.9 0.94 7.5 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Ctr PF04145.15 CDI74491.1 - 0.1 13.2 3.3 11 6.6 0.2 3.0 3 0 0 3 3 3 0 Ctr copper transporter family Peroxin-13_N PF04088.13 CDI74491.1 - 0.11 12.7 7.5 1.2 9.4 0.1 3.0 3 0 0 3 3 3 0 Peroxin 13, N-terminal region MCU PF04678.13 CDI74491.1 - 0.11 12.5 15.2 1.4 9.0 4.7 3.2 3 0 0 3 3 3 0 Mitochondrial calcium uniporter FHIPEP PF00771.20 CDI74491.1 - 0.15 10.5 13.1 0.057 11.9 2.7 2.7 3 0 0 3 3 3 0 FHIPEP family DUF4770 PF15994.5 CDI74491.1 - 0.15 12.3 16.5 1.3 9.2 4.6 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4770) TMEM51 PF15345.6 CDI74491.1 - 0.18 11.6 14.5 0.85 9.4 1.4 3.1 3 0 0 3 3 3 0 Transmembrane protein 51 Mlh1_C PF16413.5 CDI74491.1 - 0.21 10.9 11.7 1.7 8.0 1.8 3.0 3 0 0 3 3 3 0 DNA mismatch repair protein Mlh1 C-terminus CLN3 PF02487.17 CDI74491.1 - 0.25 10.4 5.2 2.9 6.8 0.3 2.7 3 0 0 3 3 3 0 CLN3 protein DUF4578 PF15147.6 CDI74491.1 - 0.29 12.0 20.4 2.2 9.1 4.2 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4578) Spt20 PF12090.8 CDI74491.1 - 0.39 10.3 51.6 1.4 8.5 15.8 3.1 3 0 0 3 3 3 0 Spt20 family EOS1 PF12326.8 CDI74491.1 - 0.47 10.4 5.9 3.2 7.6 6.0 2.1 1 1 0 1 1 1 0 N-glycosylation protein DUF1644 PF07800.12 CDI74491.1 - 0.55 10.3 9.7 1.6 8.8 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1644) DUF719 PF05334.13 CDI74491.1 - 0.7 10.1 13.3 1.4 9.1 0.5 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF719) Pet20 PF08692.10 CDI74491.1 - 1 10.1 4.7 24 5.7 0.4 3.0 3 0 0 3 3 3 0 Mitochondrial protein Pet20 Slu7 PF11708.8 CDI74491.1 - 1.6 8.4 13.7 1.3 8.7 0.4 2.9 3 0 0 3 3 3 0 Pre-mRNA splicing Prp18-interacting factor Connexin PF00029.19 CDI74491.1 - 1.6 8.4 8.1 5.8 6.6 1.2 2.6 3 0 0 3 3 3 0 Connexin DUF2371 PF10177.9 CDI74491.1 - 1.7 8.8 3.2 13 6.0 0.0 2.6 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2371) ANAPC_CDC26 PF10471.9 CDI74491.1 - 1.9 9.3 46.6 4.2 8.3 12.7 3.6 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 Rxt3 PF08642.10 CDI74491.1 - 2.3 9.0 7.9 6.3 7.6 0.5 2.8 3 0 0 3 3 2 0 Histone deacetylation protein Rxt3 NPR1_interact PF15699.5 CDI74491.1 - 2.3 8.9 17.3 2.9 8.6 4.7 3.0 3 0 0 3 3 3 0 NPR1 interacting DUF4820 PF16091.5 CDI74491.1 - 3 7.2 11.7 5.3 6.3 0.8 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4820) PH_4 PF15404.6 CDI74491.1 - 3.6 7.3 13.0 4.5 7.0 1.3 3.1 4 0 0 4 4 4 0 Pleckstrin homology domain MFAP1 PF06991.11 CDI74491.1 - 3.8 7.3 19.6 0.065 13.1 1.1 3.0 3 0 0 3 3 3 0 Microfibril-associated/Pre-mRNA processing Sin_N PF04801.13 CDI74491.1 - 4.1 6.5 21.6 1.1 8.4 1.7 3.0 3 0 0 3 3 3 0 Sin-like protein conserved region TERB2 PF15101.6 CDI74491.1 - 4.1 7.4 23.8 1 9.4 3.0 3.1 3 0 0 3 3 3 0 Telomere-associated protein TERB2 eIF-3_zeta PF05091.12 CDI74491.1 - 4.2 6.2 16.4 0.58 9.1 1.6 2.5 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PEX11 PF05648.14 CDI74491.1 - 4.3 6.7 12.8 0.58 9.6 0.1 3.0 3 0 0 3 3 3 0 Peroxisomal biogenesis factor 11 (PEX11) RAB3GAP2_N PF14655.6 CDI74491.1 - 6.2 6.0 18.5 4.1 6.6 2.3 3.1 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Maf1 PF09174.10 CDI74491.1 - 6.3 6.9 9.7 5.2 7.2 0.2 2.8 3 0 0 3 3 3 0 Maf1 regulator Glt_symporter PF03616.14 CDI74491.1 - 6.4 5.4 9.5 1.9 7.1 3.4 2.1 2 0 0 2 2 2 0 Sodium/glutamate symporter Rsc14 PF08586.10 CDI74491.1 - 6.9 7.5 12.8 8.2 7.3 0.6 3.1 3 0 0 3 3 3 0 RSC complex, Rsc14/Ldb7 subunit RPA43_OB PF17875.1 CDI74491.1 - 8.5 7.0 10.2 12 6.5 0.1 2.8 3 0 0 3 3 2 0 RPA43 OB domain in RNA Pol I DUF4643 PF15485.6 CDI74491.1 - 9.3 6.0 25.7 0.025 14.4 3.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4643) RskA PF10099.9 CDI74492.1 - 7.5e-06 26.4 3.5 7.5e-06 26.4 3.5 14.8 1 1 6 9 9 9 3 Anti-sigma-K factor rskA PIG-U PF06728.13 CDI74493.1 - 3.1e-16 59.4 4.9 2.6e-13 49.8 0.1 2.9 3 1 0 3 3 2 2 GPI transamidase subunit PIG-U SprA-related PF12118.8 CDI74493.1 - 5.1e-05 22.6 12.4 5.1e-05 22.6 12.4 4.3 3 2 1 4 4 1 1 SprA-related family Roughex PF06020.11 CDI74493.1 - 0.007 15.5 3.1 0.007 15.5 3.1 4.8 3 1 1 4 4 2 1 Drosophila roughex protein FmiP_Thoc5 PF09766.9 CDI74493.1 - 0.0088 15.4 4.1 0.0088 15.4 4.1 3.8 3 1 1 4 4 2 1 Fms-interacting protein/Thoc5 TMEM51 PF15345.6 CDI74493.1 - 0.015 15.2 7.4 0.015 15.2 7.4 4.2 3 1 1 4 4 2 0 Transmembrane protein 51 LMBR1 PF04791.16 CDI74493.1 - 0.016 14.2 19.5 0.041 12.8 19.1 1.8 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF4271 PF14093.6 CDI74493.1 - 0.017 15.0 5.0 0.32 10.9 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4271) 7tm_3 PF00003.22 CDI74493.1 - 0.022 14.5 2.1 5.7 6.6 0.2 3.0 3 0 0 3 3 3 0 7 transmembrane sweet-taste receptor of 3 GCPR DUF1218 PF06749.12 CDI74493.1 - 0.023 15.2 9.8 0.031 14.8 1.4 3.7 3 2 0 3 3 3 0 Protein of unknown function (DUF1218) BAF1_ABF1 PF04684.13 CDI74493.1 - 0.085 11.9 39.9 0.02 14.0 3.0 3.0 3 0 0 3 3 3 0 BAF1 / ABF1 chromatin reorganising factor Spore_YhcN_YlaJ PF09580.10 CDI74493.1 - 0.12 12.5 0.0 0.12 12.5 0.0 3.2 2 1 0 2 2 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Utp14 PF04615.13 CDI74493.1 - 0.31 9.6 37.7 0.043 12.4 33.3 1.7 2 0 0 2 2 2 0 Utp14 protein Sec62 PF03839.16 CDI74493.1 - 0.68 9.4 35.4 0.26 10.8 17.8 3.3 3 0 0 3 3 3 0 Translocation protein Sec62 Connexin PF00029.19 CDI74493.1 - 1.2 8.8 42.8 0.38 10.5 6.2 3.9 2 1 1 3 3 3 0 Connexin CSG2 PF16965.5 CDI74493.1 - 1.5 7.7 37.5 0.52 9.2 14.3 3.5 2 1 1 3 3 3 0 Ceramide synthase regulator Plant_vir_prot PF01307.17 CDI74493.1 - 1.5 9.1 6.1 8.4 6.7 0.7 2.9 2 0 0 2 2 2 0 Plant viral movement protein SpoIIIAH PF12685.7 CDI74493.1 - 1.9 8.3 47.3 0.97 9.2 24.1 3.4 2 1 0 2 2 2 0 SpoIIIAH-like protein SKA1 PF07160.12 CDI74493.1 - 2.4 8.0 47.7 0.6 9.9 5.4 2.9 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 Cytochrom_B_N_2 PF13631.6 CDI74493.1 - 4.7 7.2 8.5 10 6.1 0.2 3.7 3 1 1 4 4 4 0 Cytochrome b(N-terminal)/b6/petB BatD PF13584.6 CDI74493.1 - 5 5.8 34.5 0.21 10.3 5.6 3.8 3 1 1 4 4 4 0 Oxygen tolerance CDC45 PF02724.14 CDI74493.1 - 5.5 5.1 41.2 0.39 8.9 21.8 3.0 3 1 1 4 4 4 0 CDC45-like protein NPR3 PF03666.13 CDI74493.1 - 8.6 5.0 48.3 0.087 11.6 25.1 3.2 3 0 0 3 3 3 0 Nitrogen Permease regulator of amino acid transport activity 3 TMEM247 PF15444.6 CDI74494.1 - 0.0022 18.1 7.1 0.0028 17.8 7.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 247 TFIIA PF03153.13 CDI74494.1 - 0.0035 17.4 38.4 0.0039 17.2 38.4 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI74494.1 - 0.048 13.9 29.5 0.07 13.4 29.5 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA JUPITER PF17054.5 CDI74494.1 - 0.072 12.6 7.8 0.087 12.3 7.8 1.1 1 0 0 1 1 1 0 Microtubule-Associated protein Jupiter Vfa1 PF08432.10 CDI74494.1 - 0.2 11.9 13.2 0.26 11.6 13.2 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CCSAP PF15748.5 CDI74494.1 - 0.39 10.9 22.0 0.49 10.5 22.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated RAP1 PF07218.11 CDI74494.1 - 0.63 8.3 7.2 0.74 8.0 7.2 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PAT1 PF09770.9 CDI74494.1 - 1.6 6.9 23.9 1.8 6.7 23.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SUIM_assoc PF16619.5 CDI74495.1 - 1.4 9.0 0.0 1.4 9.0 0.0 20.2 12 7 3 16 16 16 0 Unstructured region C-term to UIM in Ataxin3 Pex14_N PF04695.13 CDI74496.1 - 0.17 12.6 33.0 0.19 12.4 33.0 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Gti1_Pac2 PF09729.9 CDI74496.1 - 0.21 11.7 17.7 0.25 11.4 17.7 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family SpoIIP PF07454.11 CDI74496.1 - 0.34 10.3 21.6 0.39 10.1 21.6 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF2464 PF10240.9 CDI74496.1 - 0.47 10.0 12.6 0.59 9.7 12.6 1.2 1 0 0 1 1 1 0 Multivesicular body subunit 12 Med19 PF10278.9 CDI74496.1 - 0.57 10.1 14.5 0.6 10.0 14.5 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 SelP_N PF04592.14 CDI74496.1 - 0.92 8.9 25.4 1 8.7 25.4 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF4569 PF15133.6 CDI74496.1 - 1.1 9.0 27.1 1.3 8.7 27.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Endostatin PF06482.11 CDI74496.1 - 1.2 8.5 21.4 1.3 8.4 21.4 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin PIEZO PF15917.5 CDI74496.1 - 1.3 8.4 28.1 1.5 8.2 28.1 1.1 1 0 0 1 1 1 0 Piezo CobT PF06213.12 CDI74496.1 - 1.3 8.3 36.1 1.4 8.2 36.1 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RSRP PF17069.5 CDI74496.1 - 1.7 8.1 7.0 2.1 7.9 7.0 1.0 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Velvet PF11754.8 CDI74496.1 - 2 8.3 21.4 2.3 8.1 21.4 1.1 1 0 0 1 1 1 0 Velvet factor Presenilin PF01080.17 CDI74496.1 - 2.2 7.0 29.9 2.3 6.9 29.9 1.0 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 CDI74496.1 - 2.5 7.2 14.5 2.8 7.1 14.5 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter PTPRCAP PF15713.5 CDI74496.1 - 3 8.1 25.1 3.7 7.8 25.1 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SLC12 PF03522.15 CDI74496.1 - 3.2 6.7 25.6 3.3 6.6 25.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DDHD PF02862.17 CDI74496.1 - 3.2 7.8 21.9 3.8 7.6 21.9 1.1 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.14 CDI74496.1 - 3.4 5.8 20.9 4 5.6 20.9 1.0 1 0 0 1 1 1 0 CDC45-like protein eIF-3_zeta PF05091.12 CDI74496.1 - 4 6.3 29.0 4.4 6.2 29.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Lin-8 PF03353.15 CDI74496.1 - 5.4 6.5 30.1 5.8 6.4 30.1 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Neur_chan_memb PF02932.16 CDI74496.1 - 5.7 6.9 22.7 6.2 6.8 22.7 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Folliculin PF11704.8 CDI74496.1 - 6.7 6.5 18.4 8.5 6.2 18.4 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF913 PF06025.12 CDI74496.1 - 7.3 5.5 17.9 8.6 5.2 17.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4228 PF14009.6 CDI74496.1 - 7.6 6.9 12.7 9.6 6.6 12.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) DUF5308 PF17233.2 CDI74496.1 - 8.9 6.5 19.4 12 6.0 19.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF3408 PF11888.8 CDI74496.1 - 9.1 6.4 26.6 12 6.1 26.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Shadoo PF14999.6 CDI74497.1 - 3.9 7.6 7.8 0.22 11.6 2.7 1.5 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective RskA PF10099.9 CDI74500.1 - 0.01 16.2 12.8 0.013 15.8 12.8 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI74500.1 - 0.078 13.0 13.0 0.09 12.8 13.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI74500.1 - 0.079 12.6 6.9 0.086 12.4 6.9 1.2 1 0 0 1 1 1 0 Spt20 family FAM199X PF15814.5 CDI74500.1 - 6.7 5.7 12.6 8.9 5.3 12.6 1.2 1 0 0 1 1 1 0 Protein family FAM199X RNA_pol_Rpb2_6 PF00562.28 CDI74501.1 - 4.9e-18 65.4 2.1 2e-15 56.8 2.0 2.1 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RskA PF10099.9 CDI74501.1 - 5e-05 23.7 0.2 7.4e-05 23.1 0.2 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA RAP1 PF07218.11 CDI74501.1 - 0.0026 16.2 9.7 0.0026 16.1 9.7 1.1 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) SprA-related PF12118.8 CDI74501.1 - 0.013 14.7 22.8 0.019 14.2 22.8 1.2 1 0 0 1 1 1 0 SprA-related family DUF572 PF04502.13 CDI74501.1 - 0.036 13.7 8.4 0.044 13.4 8.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DivIC PF04977.15 CDI74501.1 - 0.35 10.7 10.9 0.4 10.5 10.1 1.5 2 0 0 2 2 2 0 Septum formation initiator TERB2 PF15101.6 CDI74501.1 - 0.7 9.9 11.7 0.4 10.7 6.1 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Spt20 PF12090.8 CDI74501.1 - 0.86 9.2 29.7 0.053 13.1 23.1 1.9 2 0 0 2 2 2 0 Spt20 family DUF4175 PF13779.6 CDI74501.1 - 2 6.2 15.0 2.6 5.8 15.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Serinc PF03348.15 CDI74501.1 - 2.1 7.2 5.8 2.7 6.8 5.8 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) SSP160 PF06933.11 CDI74501.1 - 2.9 6.0 16.3 3.4 5.8 16.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF4551 PF15087.6 CDI74501.1 - 4.3 6.0 12.4 5.3 5.7 12.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF1759 PF03564.15 CDI74502.1 - 0.091 12.7 1.4 0.14 12.0 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) Spt20 PF12090.8 CDI74503.1 - 0.0081 15.8 18.1 0.011 15.4 18.1 1.2 1 0 0 1 1 1 1 Spt20 family TERB2 PF15101.6 CDI74503.1 - 0.021 14.9 8.8 0.03 14.4 8.8 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 MDM10 PF12519.8 CDI74503.1 - 0.045 12.6 2.3 0.059 12.2 2.3 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 MMR1 PF08505.10 CDI74503.1 - 0.05 13.9 6.3 0.071 13.4 6.3 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SelP_N PF04592.14 CDI74503.1 - 0.052 12.9 13.8 0.077 12.4 13.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region AF-4 PF05110.13 CDI74503.1 - 0.12 10.4 8.3 0.15 10.1 8.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Miff PF05644.11 CDI74503.1 - 0.12 11.9 5.2 0.17 11.5 5.2 1.2 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff V_ATPase_I PF01496.19 CDI74503.1 - 0.15 9.9 4.2 0.19 9.6 4.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EIF4E-T PF10477.9 CDI74503.1 - 0.27 10.0 12.0 0.34 9.7 12.0 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Neur_chan_memb PF02932.16 CDI74503.1 - 0.29 11.1 5.3 0.42 10.6 5.3 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4834 PF16118.5 CDI74503.1 - 0.62 11.1 5.9 1.2 10.1 5.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) UPF0560 PF10577.9 CDI74503.1 - 0.71 8.3 14.2 0.95 7.9 14.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF3464 PF11947.8 CDI74503.1 - 1.7 8.4 11.6 0.27 11.0 7.1 2.0 1 1 1 2 2 2 0 Photosynthesis affected mutant 68 TMEM51 PF15345.6 CDI74503.1 - 2.1 8.1 9.9 4.4 7.1 9.9 1.6 1 0 0 1 1 1 0 Transmembrane protein 51 Roughex PF06020.11 CDI74503.1 - 2.3 7.2 8.4 4.8 6.2 8.4 1.6 1 0 0 1 1 1 0 Drosophila roughex protein Ribosomal_60s PF00428.19 CDI74504.1 - 8.7 7.0 16.9 9.4 6.9 15.2 1.9 1 1 1 2 2 2 0 60s Acidic ribosomal protein Suf PF05843.14 CDI74505.1 - 1.4 8.8 10.3 1.9 8.4 10.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DivIC PF04977.15 CDI74505.1 - 1.6 8.5 13.5 3 7.7 13.5 1.4 1 0 0 1 1 1 0 Septum formation initiator Spt20 PF12090.8 CDI74505.1 - 5 6.7 25.9 6.9 6.2 25.9 1.1 1 0 0 1 1 1 0 Spt20 family O-antigen_lig PF13425.6 CDI74506.1 - 6.5 5.4 8.9 9.6 4.9 8.9 1.4 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Sporozoite_P67 PF05642.11 CDI74507.1 - 5e-06 24.9 4.1 5e-06 24.9 4.1 1.8 1 1 1 2 2 2 1 Sporozoite P67 surface antigen SUIM_assoc PF16619.5 CDI74507.1 - 1.1 9.4 0.0 1.1 9.4 0.0 11.4 3 3 5 8 8 8 0 Unstructured region C-term to UIM in Ataxin3 Presenilin PF01080.17 CDI74508.1 - 0.00014 20.8 26.4 0.00014 20.8 26.4 1.6 1 1 0 1 1 1 1 Presenilin SPX PF03105.19 CDI74508.1 - 0.00061 19.8 11.3 0.00062 19.8 11.3 1.1 1 0 0 1 1 1 1 SPX domain DUF3043 PF11241.8 CDI74508.1 - 0.002 18.2 12.1 0.002 18.2 12.1 3.2 1 1 1 2 2 2 1 Protein of unknown function (DUF3043) Lin-8 PF03353.15 CDI74508.1 - 0.011 15.3 22.3 0.013 15.0 22.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist LMBR1 PF04791.16 CDI74508.1 - 0.021 13.7 6.5 0.028 13.3 6.5 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein CRT10 PF08728.10 CDI74508.1 - 0.11 10.6 9.9 0.12 10.5 9.9 1.0 1 0 0 1 1 1 0 CRT10 Raftlin PF15250.6 CDI74508.1 - 0.39 9.4 19.1 0.49 9.1 19.1 1.1 1 0 0 1 1 1 0 Raftlin Plasmodium_Vir PF05795.11 CDI74508.1 - 0.63 9.4 10.0 0.99 8.8 10.0 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SOG2 PF10428.9 CDI74508.1 - 1.6 7.8 24.2 1.9 7.6 24.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Cellulose_synt PF03552.14 CDI74508.1 - 1.6 7.1 4.9 2 6.8 4.9 1.3 1 0 0 1 1 1 0 Cellulose synthase Membralin PF09746.9 CDI74508.1 - 4.4 6.2 16.8 5.5 5.9 16.8 1.2 1 0 0 1 1 1 0 Tumour-associated protein Suf PF05843.14 CDI74508.1 - 8.4 6.3 28.2 14 5.5 28.2 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Dmrt1 PF12374.8 CDI74510.1 - 0.061 13.8 2.9 0.22 12.0 2.9 2.0 1 0 0 1 1 1 0 Double-sex mab3 related transcription factor 1 Hamartin PF04388.12 CDI74512.1 - 0.035 12.8 36.3 0.04 12.6 36.3 1.0 1 0 0 1 1 1 0 Hamartin protein PA26 PF04636.13 CDI74512.1 - 0.6 9.0 28.1 0.72 8.7 28.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Caldesmon PF02029.15 CDI74512.1 - 1.2 7.8 40.0 1.4 7.6 40.0 1.1 1 0 0 1 1 1 0 Caldesmon RIFIN PF02009.16 CDI74512.1 - 1.6 8.5 36.1 1.9 8.3 36.1 1.1 1 0 0 1 1 1 0 Rifin Draxin PF15550.6 CDI74512.1 - 2.1 8.1 30.9 2.9 7.7 30.9 1.2 1 0 0 1 1 1 0 Draxin Exonuc_VII_L PF02601.15 CDI74512.1 - 4.5 6.8 47.7 7 6.1 47.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4045 PF13254.6 CDI74512.1 - 5.7 6.5 41.7 8.5 5.9 41.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CDC27 PF09507.10 CDI74512.1 - 6.1 6.1 46.0 7.6 5.8 46.0 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CDC45 PF02724.14 CDI74512.1 - 6.4 4.9 35.4 7.8 4.7 35.4 1.1 1 0 0 1 1 1 0 CDC45-like protein SMYLE_N PF18615.1 CDI74512.1 - 7.4 6.0 30.4 10 5.6 30.4 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain SpoIIP PF07454.11 CDI74513.1 - 0.42 10.0 13.4 0.45 9.9 13.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Afi1 PF07792.12 CDI74513.1 - 0.95 9.9 15.3 1.2 9.7 15.3 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CagX PF03524.15 CDI74513.1 - 1.4 8.6 11.0 1.6 8.4 11.0 1.1 1 0 0 1 1 1 0 Conjugal transfer protein AGO_N PF18236.1 CDI74513.1 - 1.5 9.1 11.8 0.25 11.6 7.5 1.7 1 1 1 2 2 2 0 Argonaute N domain Presenilin PF01080.17 CDI74513.1 - 1.5 7.5 14.9 1.6 7.4 14.9 1.0 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 CDI74513.1 - 2 7.3 17.5 1.9 7.3 17.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TT_ORF1 PF02956.14 CDI74513.1 - 2.1 6.9 14.2 2.5 6.7 14.2 1.0 1 0 0 1 1 1 0 TT viral orf 1 Kei1 PF08552.11 CDI74513.1 - 2.3 8.0 7.6 2.7 7.8 7.6 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 PIG-S PF10510.9 CDI74513.1 - 2.6 6.8 18.7 2.7 6.7 18.7 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Sec62 PF03839.16 CDI74513.1 - 3.4 7.1 13.0 4 6.9 13.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 HCO3_cotransp PF00955.21 CDI74513.1 - 3.7 6.2 7.9 4.2 6.1 7.9 1.0 1 0 0 1 1 1 0 HCO3- transporter family YABBY PF04690.13 CDI74513.1 - 4 8.0 11.8 4.3 7.9 11.8 1.1 1 0 0 1 1 1 0 YABBY protein TERB2 PF15101.6 CDI74513.1 - 4.3 7.4 20.6 5.3 7.0 20.6 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Gti1_Pac2 PF09729.9 CDI74513.1 - 4.3 7.4 13.2 4.9 7.2 13.2 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Membralin PF09746.9 CDI74513.1 - 4.4 6.2 11.1 4.8 6.1 11.1 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF2828 PF11443.8 CDI74513.1 - 4.6 5.2 15.8 5 5.1 15.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DDHD PF02862.17 CDI74513.1 - 4.6 7.3 12.4 4.8 7.3 12.4 1.1 1 0 0 1 1 1 0 DDHD domain Band_3_cyto PF07565.13 CDI74513.1 - 4.6 7.0 14.7 5.9 6.6 14.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Pex14_N PF04695.13 CDI74513.1 - 4.9 7.8 21.7 6.3 7.4 21.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CSG2 PF16965.5 CDI74513.1 - 5.1 5.9 9.3 5.3 5.9 9.3 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Connexin PF00029.19 CDI74513.1 - 5.1 6.8 11.6 6 6.6 11.6 1.1 1 0 0 1 1 1 0 Connexin Hydin_ADK PF17213.3 CDI74513.1 - 5.6 7.2 12.0 6.4 7.0 12.0 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Scs3p PF10261.9 CDI74513.1 - 6.6 6.2 6.9 8 5.9 6.9 1.0 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM FAM60A PF15396.6 CDI74513.1 - 7.6 6.5 10.7 8.6 6.3 10.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A MAJIN PF15077.6 CDI74513.1 - 8.4 6.1 10.9 9.6 5.9 10.9 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein ALMT PF11744.8 CDI74513.1 - 8.5 5.1 12.1 9.4 4.9 12.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CLN3 PF02487.17 CDI74513.1 - 9.1 5.2 12.7 10 5.0 12.7 1.0 1 0 0 1 1 1 0 CLN3 protein Neur_chan_memb PF02932.16 CDI74513.1 - 9.2 6.2 11.6 9.8 6.1 11.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hist_deacetyl PF00850.19 CDI74514.1 - 1.3e-14 54.4 1.0 2.3e-14 53.6 0.1 1.9 2 0 0 2 2 2 1 Histone deacetylase domain Ank_2 PF12796.7 CDI74514.1 - 2.2e-09 37.7 0.1 4.3e-06 27.2 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDI74514.1 - 8.3e-08 32.4 4.8 1.7e-06 28.2 0.3 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDI74514.1 - 5.9e-07 29.9 6.9 0.00093 19.7 0.5 5.4 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI74514.1 - 3.6e-06 26.9 5.3 0.18 12.5 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeat MID_MedPIWI PF18296.1 CDI74514.1 - 2.7e-05 24.1 13.7 0.0013 18.5 0.4 3.9 4 0 0 4 4 4 2 MID domain of medPIWI Ank PF00023.30 CDI74514.1 - 4.2e-05 23.8 14.2 0.0012 19.2 0.9 4.7 4 0 0 4 4 4 2 Ankyrin repeat DUF4667 PF15700.5 CDI74514.1 - 0.00033 20.8 26.2 0.021 14.9 1.1 4.0 4 0 0 4 4 4 3 Domain of unknown function (DUF4667) SPX PF03105.19 CDI74514.1 - 0.006 16.5 13.6 0.029 14.3 3.6 2.4 2 0 0 2 2 2 2 SPX domain DUF1645 PF07816.11 CDI74514.1 - 2.3 8.7 42.6 0.37 11.3 2.9 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1645) RskA PF10099.9 CDI74514.1 - 9.9 6.4 39.3 0.78 10.0 0.5 3.7 4 0 0 4 4 4 0 Anti-sigma-K factor rskA DUF4145 PF13643.6 CDI74515.1 - 0.065 13.4 0.3 0.065 13.4 0.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4145) DUF445 PF04286.12 CDI74515.1 - 0.95 9.2 20.7 1.2 8.8 20.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DUF4805 PF16063.5 CDI74518.1 - 0.08 12.3 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) AP2 PF00847.20 CDI74519.1 - 3.2e-05 24.1 2.5 5.9e-05 23.2 2.5 1.4 1 0 0 1 1 1 1 AP2 domain TFIIA PF03153.13 CDI74519.1 - 0.24 11.4 7.8 0.49 10.3 7.8 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glyco_hydro_26 PF02156.15 CDI74520.1 - 0.056 12.9 0.2 0.45 9.9 0.0 2.3 2 0 0 2 2 2 0 Glycosyl hydrolase family 26 DUF4275 PF14101.6 CDI74520.1 - 0.088 13.0 0.4 0.18 11.9 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4275) Methyltransf_29 PF03141.16 CDI74520.1 - 0.51 8.8 4.7 0.94 7.9 4.7 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase V_ATPase_I PF01496.19 CDI74520.1 - 1.4 6.7 10.9 2.3 6.1 10.9 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SPX PF03105.19 CDI74520.1 - 2.7 7.8 17.0 0.027 14.4 7.6 2.0 2 1 0 2 2 2 0 SPX domain TFIIA PF03153.13 CDI74520.1 - 3.7 7.4 41.3 10 6.0 41.3 1.7 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spore_III_AB PF09548.10 CDI74520.1 - 4.3 7.4 21.4 26 4.9 21.4 2.2 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DUF3461 PF11944.8 CDI74520.1 - 7.3 6.7 11.6 0.22 11.7 2.4 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3461) Membralin PF09746.9 CDI74522.1 - 0.0064 15.6 0.2 0.0064 15.6 0.2 4.3 3 1 0 3 3 3 1 Tumour-associated protein Pex14_N PF04695.13 CDI74522.1 - 0.0097 16.6 12.7 0.0097 16.6 12.7 8.9 5 1 3 8 8 8 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Nha1_C PF08619.10 CDI74522.1 - 7.8 5.6 0.0 0.06 12.6 4.4 5.5 3 1 3 6 6 6 0 Alkali metal cation/H+ antiporter Nha1 C terminus RR_TM4-6 PF06459.12 CDI74523.1 - 0.0048 16.8 17.9 0.0054 16.6 17.9 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Peptidase_S49_N PF08496.10 CDI74523.1 - 0.031 14.3 14.6 0.048 13.7 14.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RPN2_C PF18004.1 CDI74523.1 - 0.037 13.9 14.9 0.045 13.7 14.9 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain MecA PF05389.12 CDI74523.1 - 0.09 12.4 11.8 0.12 12.0 11.8 1.3 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) PCEMA1 PF07418.11 CDI74523.1 - 0.097 12.2 9.9 0.12 11.9 9.9 1.0 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 TRAP_alpha PF03896.16 CDI74523.1 - 0.11 11.7 6.3 0.15 11.2 6.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit ALMT PF11744.8 CDI74523.1 - 0.18 10.6 16.5 0.22 10.3 16.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Serinc PF03348.15 CDI74523.1 - 0.21 10.5 11.2 0.23 10.3 11.2 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) HMG14_17 PF01101.18 CDI74523.1 - 0.22 12.5 12.0 0.37 11.8 12.0 1.4 1 1 0 1 1 1 0 HMG14 and HMG17 DUF4337 PF14235.6 CDI74523.1 - 0.28 11.3 13.7 0.31 11.1 13.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) PNISR PF15996.5 CDI74523.1 - 0.31 11.3 21.2 0.47 10.7 21.2 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR CCSAP PF15748.5 CDI74523.1 - 0.31 11.2 25.9 0.38 10.9 25.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CSG2 PF16965.5 CDI74523.1 - 0.33 9.8 9.4 0.41 9.5 9.4 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator Med13_C PF06333.12 CDI74523.1 - 0.34 10.1 16.5 0.39 9.9 16.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain CDK5_activator PF03261.15 CDI74523.1 - 0.44 10.1 20.3 0.5 9.8 20.3 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein MAP70 PF07058.11 CDI74523.1 - 0.51 9.0 14.1 0.59 8.8 14.1 1.0 1 0 0 1 1 1 0 Microtubule-associated protein 70 V_ATPase_I PF01496.19 CDI74523.1 - 0.53 8.1 22.2 0.65 7.8 22.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2126 PF09899.9 CDI74523.1 - 0.57 8.2 11.4 0.62 8.1 11.4 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) HCO3_cotransp PF00955.21 CDI74523.1 - 0.62 8.8 8.5 0.7 8.6 8.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family SID-1_RNA_chan PF13965.6 CDI74523.1 - 0.62 8.4 10.5 0.69 8.2 10.5 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PPP4R2 PF09184.11 CDI74523.1 - 0.63 9.6 19.0 0.8 9.2 19.0 1.0 1 0 0 1 1 1 0 PPP4R2 Asp-B-Hydro_N PF05279.11 CDI74523.1 - 0.64 10.0 11.0 0.66 10.0 11.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Presenilin PF01080.17 CDI74523.1 - 0.65 8.7 25.9 0.86 8.3 25.9 1.2 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI74523.1 - 0.89 9.5 41.3 1.2 9.0 41.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Endostatin PF06482.11 CDI74523.1 - 0.9 8.9 22.5 1.1 8.7 22.5 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF2828 PF11443.8 CDI74523.1 - 0.91 7.5 17.4 1 7.4 17.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Spore_coat_CotO PF14153.6 CDI74523.1 - 0.93 9.4 24.3 1.1 9.2 24.3 1.2 1 0 0 1 1 1 0 Spore coat protein CotO MCU PF04678.13 CDI74523.1 - 0.97 9.5 11.4 1.2 9.2 11.4 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter CLN3 PF02487.17 CDI74523.1 - 1 8.3 15.5 1.1 8.2 15.5 1.2 1 0 0 1 1 1 0 CLN3 protein DUF4407 PF14362.6 CDI74523.1 - 1.1 8.5 16.7 1.4 8.2 16.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2370 PF10176.9 CDI74523.1 - 1.2 8.7 8.5 1.5 8.4 8.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) CBP_BcsG PF11658.8 CDI74523.1 - 1.2 7.4 13.1 1.6 7.0 13.1 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG eIF-3_zeta PF05091.12 CDI74523.1 - 1.4 7.9 23.3 1.7 7.6 23.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) O-antigen_lig PF13425.6 CDI74523.1 - 1.4 7.6 10.3 1.6 7.5 10.3 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4746 PF15928.5 CDI74523.1 - 1.5 8.1 13.9 1.8 7.9 13.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Nucleoside_tran PF01733.18 CDI74523.1 - 1.9 7.8 5.6 2.1 7.6 5.6 1.2 1 0 0 1 1 1 0 Nucleoside transporter DDHD PF02862.17 CDI74523.1 - 2.2 8.4 19.9 3 7.9 19.9 1.2 1 0 0 1 1 1 0 DDHD domain Ureide_permease PF07168.11 CDI74523.1 - 2.4 6.8 6.8 2.6 6.7 6.8 1.3 1 0 0 1 1 1 0 Ureide permease MAM33 PF02330.16 CDI74523.1 - 2.7 7.9 20.8 3.7 7.4 9.5 2.1 1 1 1 2 2 2 0 Mitochondrial glycoprotein TCP PF03634.13 CDI74523.1 - 3.1 8.3 25.3 4.2 7.9 25.3 1.2 1 0 0 1 1 1 0 TCP family transcription factor PAT1 PF09770.9 CDI74523.1 - 3.1 5.9 33.8 3.5 5.8 33.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LAP1C PF05609.12 CDI74523.1 - 3.2 6.8 23.8 3.7 6.5 23.8 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Neur_chan_memb PF02932.16 CDI74523.1 - 3.4 7.7 17.6 4.7 7.2 17.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Membralin PF09746.9 CDI74523.1 - 3.8 6.4 14.3 4.4 6.3 14.3 1.2 1 0 0 1 1 1 0 Tumour-associated protein Paf1 PF03985.13 CDI74523.1 - 4.3 6.2 25.5 5.1 6.0 25.5 1.1 1 0 0 1 1 1 0 Paf1 MTBP_C PF14920.6 CDI74523.1 - 5 6.8 25.5 7.9 6.2 25.5 1.3 1 0 0 1 1 1 0 MDM2-binding CAC1F_C PF16885.5 CDI74523.1 - 5.2 6.6 18.6 6.2 6.4 18.6 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term SOBP PF15279.6 CDI74523.1 - 5.5 7.5 25.2 6.6 7.2 25.2 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein SelP_N PF04592.14 CDI74523.1 - 5.6 6.3 28.6 7.2 5.9 28.6 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Connexin PF00029.19 CDI74523.1 - 5.7 6.6 21.1 4.4 7.0 20.0 1.4 1 1 0 1 1 1 0 Connexin PepSY_TM PF03929.16 CDI74523.1 - 6.5 6.3 7.7 7.7 6.1 7.7 1.3 1 0 0 1 1 1 0 PepSY-associated TM region DUF4175 PF13779.6 CDI74523.1 - 7.4 4.3 37.1 8 4.2 37.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) LptF_LptG PF03739.14 CDI74523.1 - 8 5.2 7.8 8.6 5.1 7.8 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG CKAP2_C PF15297.6 CDI74523.1 - 9.5 5.2 20.3 3.4 6.7 17.7 1.5 1 1 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus SLC12 PF03522.15 CDI74523.1 - 9.8 5.1 23.4 12 4.8 23.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4366 PF14283.6 CDI74524.1 - 0.0017 18.4 3.9 0.0022 18.0 3.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) PIP5K PF01504.18 CDI74524.1 - 0.0038 16.5 8.8 0.0044 16.3 8.8 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Serinc PF03348.15 CDI74524.1 - 0.0041 16.1 5.1 0.0045 16.0 5.1 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF5427 PF10310.9 CDI74524.1 - 0.0066 15.5 15.4 0.01 14.8 15.4 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5427) DUF913 PF06025.12 CDI74524.1 - 0.0074 15.3 4.0 0.0084 15.1 4.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Trp_oprn_chp PF09534.10 CDI74524.1 - 0.011 15.5 5.2 0.011 15.5 5.2 2.0 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Presenilin PF01080.17 CDI74524.1 - 0.011 14.5 12.5 0.013 14.3 12.5 1.1 1 0 0 1 1 1 0 Presenilin RRN9 PF10680.9 CDI74524.1 - 0.012 15.9 9.0 0.02 15.2 1.5 2.1 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor WTX PF09422.10 CDI74524.1 - 0.014 14.5 3.7 0.015 14.4 3.7 1.0 1 0 0 1 1 1 0 WTX protein Pex14_N PF04695.13 CDI74524.1 - 0.016 15.9 35.4 0.072 13.7 35.4 1.7 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SARAF PF06682.12 CDI74524.1 - 0.018 14.7 9.1 0.022 14.4 9.1 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis SLC12 PF03522.15 CDI74524.1 - 0.02 14.0 9.6 0.021 13.9 9.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PA26 PF04636.13 CDI74524.1 - 0.02 13.8 8.9 0.023 13.6 8.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Tim54 PF11711.8 CDI74524.1 - 0.021 13.6 6.9 0.024 13.4 6.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 WBP-1 PF11669.8 CDI74524.1 - 0.023 15.3 8.5 0.023 15.3 8.5 2.1 1 1 1 2 2 2 0 WW domain-binding protein 1 Velvet PF11754.8 CDI74524.1 - 0.025 14.6 10.7 0.027 14.4 10.7 1.1 1 0 0 1 1 1 0 Velvet factor Sin_N PF04801.13 CDI74524.1 - 0.029 13.6 20.5 0.032 13.4 20.5 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region AUX_IAA PF02309.16 CDI74524.1 - 0.031 14.1 6.5 0.038 13.8 6.5 1.1 1 0 0 1 1 1 0 AUX/IAA family Sec62 PF03839.16 CDI74524.1 - 0.043 13.3 7.2 0.05 13.1 7.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 PAT1 PF09770.9 CDI74524.1 - 0.044 12.1 26.3 0.045 12.0 26.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TRAP_alpha PF03896.16 CDI74524.1 - 0.046 12.9 3.5 0.058 12.6 3.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CLN3 PF02487.17 CDI74524.1 - 0.05 12.7 7.6 0.054 12.6 7.6 1.1 1 0 0 1 1 1 0 CLN3 protein Folliculin PF11704.8 CDI74524.1 - 0.065 13.1 7.5 0.079 12.8 7.5 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Mgr1 PF08602.10 CDI74524.1 - 0.07 12.0 0.1 0.07 12.0 0.1 1.9 1 1 1 2 2 2 0 Mgr1-like, i-AAA protease complex subunit CSG2 PF16965.5 CDI74524.1 - 0.087 11.8 3.8 0.098 11.6 3.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator PIG-U PF06728.13 CDI74524.1 - 0.095 11.7 1.4 0.15 11.1 1.4 1.4 1 1 0 1 1 1 0 GPI transamidase subunit PIG-U ALMT PF11744.8 CDI74524.1 - 0.13 11.0 8.4 0.13 11.1 8.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Dicty_REP PF05086.12 CDI74524.1 - 0.14 10.2 8.4 0.15 10.0 8.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FAM163 PF15069.6 CDI74524.1 - 0.14 12.6 11.0 0.17 12.3 11.0 1.1 1 0 0 1 1 1 0 FAM163 family Bap31 PF05529.12 CDI74524.1 - 0.16 11.8 8.5 0.32 10.9 8.5 1.4 1 1 0 1 1 1 0 Bap31/Bap29 transmembrane region DUF4050 PF13259.6 CDI74524.1 - 0.17 12.2 10.1 0.2 12.0 10.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) MDM10 PF12519.8 CDI74524.1 - 0.18 10.6 7.6 0.21 10.4 7.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 INSIG PF07281.12 CDI74524.1 - 0.21 11.2 3.8 0.26 10.9 3.8 1.3 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) DUF2828 PF11443.8 CDI74524.1 - 0.24 9.5 12.4 0.29 9.2 12.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) V_ATPase_I PF01496.19 CDI74524.1 - 0.4 8.5 16.4 0.5 8.2 16.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4064 PF13273.6 CDI74524.1 - 0.4 11.0 6.7 1.8 8.9 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) Neur_chan_memb PF02932.16 CDI74524.1 - 0.42 10.6 11.2 0.46 10.5 11.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2464 PF10240.9 CDI74524.1 - 0.45 10.0 8.7 0.57 9.7 8.7 1.0 1 0 0 1 1 1 0 Multivesicular body subunit 12 Lin-8 PF03353.15 CDI74524.1 - 0.46 10.0 17.2 0.54 9.8 17.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist dsDNA_bind PF01984.20 CDI74524.1 - 0.48 10.7 36.8 0.53 10.6 13.0 2.1 2 0 0 2 2 2 0 Double-stranded DNA-binding domain DUF2722 PF10846.8 CDI74524.1 - 0.53 9.2 47.6 0.024 13.6 16.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) EphA2_TM PF14575.6 CDI74524.1 - 0.65 10.9 20.5 1.4 9.8 5.8 2.2 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF1345 PF07077.11 CDI74524.1 - 0.74 9.5 4.8 5 6.8 4.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1345) RR_TM4-6 PF06459.12 CDI74524.1 - 0.89 9.3 12.8 1.3 8.8 12.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 tRNA_synt_1c_R2 PF04557.15 CDI74524.1 - 0.94 10.4 10.1 2.8 8.9 1.6 2.2 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DUF4207 PF13904.6 CDI74524.1 - 1.2 8.8 33.2 0.53 9.9 11.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) DUF2126 PF09899.9 CDI74524.1 - 1.4 6.9 9.4 1.7 6.6 9.4 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CitMHS_2 PF16980.5 CDI74524.1 - 1.4 7.5 3.5 1.7 7.2 0.7 1.8 1 1 1 2 2 2 0 Putative citrate transport NPR1_interact PF15699.5 CDI74524.1 - 2.3 8.9 16.7 4 8.1 1.9 2.1 2 0 0 2 2 2 0 NPR1 interacting GRP PF07172.11 CDI74524.1 - 2.4 8.9 7.4 3.6 8.3 1.1 2.2 1 1 1 2 2 2 0 Glycine rich protein family Conotoxin PF02950.17 CDI74524.1 - 2.5 9.2 18.2 1.9 9.6 4.9 2.2 1 1 1 2 2 2 0 Conotoxin Gaa1 PF04114.14 CDI74524.1 - 2.5 7.0 10.7 1.3 7.9 1.7 2.0 1 1 1 2 2 2 0 Gaa1-like, GPI transamidase component Peptidase_U57 PF05582.12 CDI74524.1 - 2.8 7.1 9.8 4.1 6.6 9.8 1.3 1 0 0 1 1 1 0 YabG peptidase U57 Hid1 PF12722.7 CDI74524.1 - 3.7 5.6 13.6 4.5 5.3 13.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PH_10 PF15411.6 CDI74524.1 - 3.8 7.8 15.1 1.8 8.8 1.5 2.0 1 1 1 2 2 2 0 Pleckstrin homology domain Radical_SAM_N PF08497.10 CDI74524.1 - 3.8 6.7 8.9 4.4 6.5 8.9 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal TORC_M PF12885.7 CDI74524.1 - 4.5 7.2 10.0 5.1 7.0 10.0 1.1 1 0 0 1 1 1 0 Transducer of regulated CREB activity middle domain 7tm_2 PF00002.24 CDI74524.1 - 6.2 6.0 7.1 6.4 6.0 1.9 2.0 1 1 1 2 2 2 0 7 transmembrane receptor (Secretin family) STAC2_u1 PF16664.5 CDI74524.1 - 6.6 7.2 12.4 9.5 6.7 12.4 1.3 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 DUF4660 PF15559.6 CDI74524.1 - 6.9 7.0 12.5 5.5 7.4 3.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4660) O-antigen_lig PF13425.6 CDI74524.1 - 8.2 5.1 8.0 11 4.7 8.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein VIT1 PF01988.19 CDI74524.1 - 9.4 6.0 10.9 13 5.6 10.9 1.2 1 0 0 1 1 1 0 VIT family AAA_23 PF13476.6 CDI74525.1 - 0.71 10.3 25.0 0.87 10.1 25.0 1.0 1 0 0 1 1 1 0 AAA domain Fasciclin PF02469.22 CDI74526.1 - 8.1e-07 29.3 10.1 5.7e-05 23.3 8.2 2.5 2 1 0 2 2 2 1 Fasciclin domain TFIIA PF03153.13 CDI74526.1 - 0.00012 22.3 44.9 0.00019 21.6 44.9 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit AAA_23 PF13476.6 CDI74526.1 - 0.013 16.0 22.5 0.013 16.0 22.5 1.9 2 0 0 2 2 2 0 AAA domain RE_NgoFVII PF09565.10 CDI74526.1 - 0.02 14.2 7.0 0.03 13.6 7.0 1.2 1 0 0 1 1 1 0 NgoFVII restriction endonuclease FapA PF03961.13 CDI74526.1 - 0.093 11.3 7.4 0.072 11.7 6.0 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A NAD_binding_1 PF00175.21 CDI74526.1 - 0.15 12.7 13.0 0.97 10.1 11.7 2.1 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain DDHD PF02862.17 CDI74526.1 - 0.4 10.8 9.3 0.68 10.0 9.3 1.4 1 0 0 1 1 1 0 DDHD domain V_ATPase_I PF01496.19 CDI74526.1 - 0.5 8.2 12.7 0.74 7.7 12.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PAT1 PF09770.9 CDI74526.1 - 0.94 7.7 28.6 1.6 6.9 28.6 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 CDI74526.1 - 1.4 7.6 14.5 2.3 6.9 14.5 1.2 1 0 0 1 1 1 0 Presenilin Band_3_cyto PF07565.13 CDI74526.1 - 1.8 8.3 11.7 3.3 7.5 11.7 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2347 PF09804.9 CDI74526.1 - 2.6 7.5 9.8 4.4 6.8 9.8 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Cwf_Cwc_15 PF04889.12 CDI74526.1 - 3 7.5 15.3 5.3 6.7 15.3 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CCSAP PF15748.5 CDI74526.1 - 4 7.5 13.8 6.5 6.9 13.8 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Zip PF02535.22 CDI74526.1 - 4.3 6.5 6.0 6.2 5.9 6.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CLN3 PF02487.17 CDI74526.1 - 5.9 5.8 9.6 10 5.0 9.6 1.3 1 0 0 1 1 1 0 CLN3 protein eIF-3_zeta PF05091.12 CDI74526.1 - 6.3 5.7 18.1 8.7 5.2 18.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EOS1 PF12326.8 CDI74526.1 - 9.3 6.1 11.0 32 4.4 11.0 1.7 1 1 0 1 1 1 0 N-glycosylation protein RCC1 PF00415.18 CDI74527.1 - 7.7e-10 39.2 7.7 2.4e-08 34.5 0.2 4.4 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDI74527.1 - 1.6e-06 27.7 16.5 0.0015 18.3 0.3 4.1 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat zf-RanBP PF00641.18 CDI74527.1 - 1.7e-05 24.0 5.4 4.1e-05 22.8 5.4 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 CDI74527.1 - 0.015 14.6 0.8 0.22 11.0 0.8 3.2 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Suf PF05843.14 CDI74529.1 - 1.3 9.0 7.4 1.4 8.8 7.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Spc7_N PF15402.6 CDI74529.1 - 4.7 5.3 16.7 5.3 5.2 16.7 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 CDC27 PF09507.10 CDI74529.1 - 6.1 6.1 15.7 9 5.6 15.7 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nucleo_P87 PF07267.11 CDI74529.1 - 9.2 5.0 9.4 9.6 4.9 9.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TFIIA PF03153.13 CDI74529.1 - 9.3 6.1 22.2 11 5.8 22.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Myc_N PF01056.18 CDI74529.1 - 9.4 6.0 9.5 12 5.7 9.5 1.0 1 0 0 1 1 1 0 Myc amino-terminal region Hamartin PF04388.12 CDI74529.1 - 9.4 4.8 13.8 11 4.6 13.8 1.1 1 0 0 1 1 1 0 Hamartin protein Spt20 PF12090.8 CDI74531.1 - 0.0014 18.3 14.3 0.0016 18.1 14.3 1.2 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI74531.1 - 0.0014 17.6 8.5 0.0015 17.5 8.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TMEM51 PF15345.6 CDI74531.1 - 0.003 17.5 7.9 0.0033 17.3 7.9 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 Ribosomal_60s PF00428.19 CDI74531.1 - 0.015 15.9 12.9 0.028 15.0 12.9 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein BBS2_N PF14781.6 CDI74531.1 - 0.015 15.2 0.5 0.026 14.4 0.5 1.4 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, N-terminal TFIIA PF03153.13 CDI74531.1 - 0.084 12.8 18.4 0.11 12.5 18.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Protamine_P2 PF00841.19 CDI74531.1 - 0.17 12.3 6.6 0.29 11.6 6.6 1.4 1 0 0 1 1 1 0 Sperm histone P2 CWC25 PF12542.8 CDI74531.1 - 0.37 11.7 12.0 0.43 11.5 6.2 2.3 2 0 0 2 2 2 0 Pre-mRNA splicing factor ANAPC_CDC26 PF10471.9 CDI74531.1 - 0.77 10.6 20.1 4.2 8.3 14.9 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 RskA PF10099.9 CDI74531.1 - 0.86 9.9 19.0 0.14 12.5 0.8 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA TERB2 PF15101.6 CDI74531.1 - 6.6 6.7 10.5 7.3 6.6 10.3 1.3 1 1 0 1 1 1 0 Telomere-associated protein TERB2 TFIIA PF03153.13 CDI74532.1 - 0.01 15.9 35.6 0.013 15.5 35.6 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Hamartin PF04388.12 CDI74532.1 - 6.1 5.4 24.2 8.9 4.8 24.2 1.2 1 0 0 1 1 1 0 Hamartin protein V_ATPase_I PF01496.19 CDI74533.1 - 0.0016 16.5 19.5 0.0016 16.5 19.5 2.0 1 1 1 2 2 1 1 V-type ATPase 116kDa subunit family Wzy_C PF04932.15 CDI74533.1 - 0.049 13.3 0.1 0.15 11.7 0.0 1.9 1 1 1 2 2 2 0 O-Antigen ligase DUF4834 PF16118.5 CDI74533.1 - 0.067 14.2 53.9 1.8e+04 -13.7 53.9 3.0 1 1 0 1 1 0 0 Domain of unknown function (DUF4834) CitMHS PF03600.16 CDI74533.1 - 0.19 10.9 0.0 0.2 10.8 0.0 1.0 1 0 0 1 1 1 0 Citrate transporter PA26 PF04636.13 CDI74533.1 - 0.49 9.2 30.5 0.63 8.9 30.5 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Pex24p PF06398.11 CDI74533.1 - 3.2 6.7 21.4 46 2.8 21.4 2.2 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin CCSAP PF15748.5 CDI74533.1 - 5.1 7.2 54.1 5.7 7.0 54.1 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SDA1 PF05285.12 CDI74533.1 - 7.2 5.9 39.9 9.5 5.5 39.9 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 CDI74533.1 - 7.4 4.6 42.2 8.8 4.4 42.2 1.0 1 0 0 1 1 1 0 Nop14-like family WTX PF09422.10 CDI74533.1 - 7.9 5.4 30.0 9.5 5.2 30.0 1.1 1 0 0 1 1 1 0 WTX protein Dsh_C PF12316.8 CDI74533.1 - 8.3 6.8 23.1 12 6.2 23.1 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal SLC12 PF03522.15 CDI74533.1 - 8.8 5.2 46.4 11 5.0 46.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SLC12 PF03522.15 CDI74534.1 - 0.68 8.9 19.7 0.84 8.6 19.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF908 PF06012.12 CDI74534.1 - 1.1 8.6 14.0 1.5 8.1 14.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) FAM195 PF14799.6 CDI74534.1 - 1.2 9.6 24.7 0.34 11.3 12.6 2.2 2 0 0 2 2 2 0 FAM195 family Presenilin PF01080.17 CDI74534.1 - 1.5 7.5 22.9 2.1 7.0 22.9 1.2 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 CDI74534.1 - 2.2 6.9 21.1 2.6 6.6 21.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RBM39linker PF15519.6 CDI74534.1 - 3.1 8.9 17.8 2.8 9.1 2.2 2.2 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein PRC2_HTH_1 PF18118.1 CDI74534.1 - 3.6 8.5 15.0 9.3 7.1 5.8 2.1 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain LMBR1 PF04791.16 CDI74534.1 - 4.2 6.2 15.5 4.6 6.0 15.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3408 PF11888.8 CDI74534.1 - 5.7 7.1 23.2 1.8 8.7 4.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) OmpH PF03938.14 CDI74534.1 - 6 7.2 47.9 0.75 10.1 21.0 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF5327 PF17261.2 CDI74534.1 - 7.3 7.4 27.3 4.9 8.0 8.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5327) Caudo_TAP PF02413.17 CDI74534.1 - 8.8 6.5 21.8 1.4 9.1 6.0 2.3 2 0 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK AIF_C PF14721.6 CDI74534.1 - 8.9 6.7 15.3 7.8 6.9 2.9 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term UCH PF00443.29 CDI74535.1 - 1.1e-23 84.1 0.0 1.1e-23 84.1 0.0 3.0 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase RskA PF10099.9 CDI74535.1 - 0.0029 17.9 0.0 0.0029 17.9 0.0 10.6 7 4 1 9 9 9 1 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI74535.1 - 0.0064 16.5 4.4 0.0064 16.5 4.4 15.7 13 2 0 13 13 13 4 Unstructured region C-term to UIM in Ataxin3 GDP_Man_Dehyd PF16363.5 CDI74537.1 - 2e-98 329.8 0.3 6.7e-82 275.5 0.1 2.0 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDI74537.1 - 1.2e-61 208.2 0.0 1.4e-61 208.0 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CDI74537.1 - 2.9e-08 33.2 0.0 3.9e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CDI74537.1 - 0.0014 17.9 0.0 0.0026 17.0 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 CDI74537.1 - 0.0014 18.3 0.0 0.0025 17.4 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family TFIIA PF03153.13 CDI74538.1 - 0.00018 21.7 19.7 0.00023 21.3 19.7 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI74538.1 - 0.00098 18.8 11.1 0.0017 18.0 11.1 1.5 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein UPF0524 PF15823.5 CDI74538.1 - 0.024 14.1 1.8 0.024 14.1 1.8 2.4 2 1 0 2 2 2 0 UPF0524 of C3orf70 DUF5327 PF17261.2 CDI74538.1 - 0.046 14.5 4.1 0.046 14.5 4.1 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5327) MMgT PF10270.9 CDI74538.1 - 0.073 13.4 0.1 0.12 12.7 0.1 1.4 1 0 0 1 1 1 0 Membrane magnesium transporter PPP4R2 PF09184.11 CDI74538.1 - 0.13 11.8 9.5 0.16 11.5 9.5 1.1 1 0 0 1 1 1 0 PPP4R2 Bowman-Birk_leg PF00228.20 CDI74538.1 - 0.14 12.6 1.0 0.28 11.6 1.0 1.5 1 0 0 1 1 1 0 Bowman-Birk serine protease inhibitor family Presenilin PF01080.17 CDI74538.1 - 0.32 9.7 14.6 0.46 9.2 14.6 1.2 1 0 0 1 1 1 0 Presenilin MscS_TM PF12794.7 CDI74538.1 - 0.85 8.4 4.9 8.3 5.2 4.4 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 PA26 PF04636.13 CDI74538.1 - 0.86 8.5 6.6 1.1 8.1 6.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Spt20 PF12090.8 CDI74538.1 - 1.4 8.5 28.8 0.12 11.9 16.7 2.1 2 0 0 2 2 2 0 Spt20 family MRF_C2 PF13888.6 CDI74538.1 - 1.5 8.7 11.0 2.9 7.8 10.8 1.6 1 1 0 1 1 1 0 Myelin gene regulatory factor C-terminal domain 2 DUF3464 PF11947.8 CDI74538.1 - 1.9 8.2 10.5 8.9 6.1 0.2 2.4 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 TMEM51 PF15345.6 CDI74538.1 - 3.1 7.6 17.1 5.3 6.8 15.7 2.1 1 1 0 1 1 1 0 Transmembrane protein 51 FAM176 PF14851.6 CDI74538.1 - 3.5 7.3 10.8 1.7 8.3 4.5 2.2 2 0 0 2 2 2 0 FAM176 family DUF4834 PF16118.5 CDI74538.1 - 5.3 8.1 16.8 0.74 10.8 6.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RskA PF10099.9 CDI74540.1 - 6.2e-06 26.6 31.6 7.6e-05 23.1 14.1 10.2 3 3 4 7 7 7 4 Anti-sigma-K factor rskA K_channel_TID PF07941.11 CDI74540.1 - 0.0011 19.4 16.8 0.0011 19.4 16.8 18.5 10 6 4 14 14 14 3 Potassium channel Kv1.4 tandem inactivation domain SRP-alpha_N PF04086.13 CDI74540.1 - 0.55 10.1 0.0 0.55 10.1 0.0 4.9 2 1 2 5 5 5 0 Signal recognition particle, alpha subunit, N-terminal SseC PF04888.12 CDI74541.1 - 0.00011 21.9 13.7 0.00011 21.9 13.7 14.4 11 4 3 15 15 15 2 Secretion system effector C (SseC) like family DUF2722 PF10846.8 CDI74541.1 - 0.0002 20.5 14.8 0.0002 20.5 14.8 12.8 7 4 4 12 12 12 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI74541.1 - 0.00067 20.0 2.5 0.00067 20.0 2.5 17.0 3 3 9 13 13 13 5 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI74541.1 - 0.00074 19.2 23.9 0.00074 19.2 23.9 12.0 5 3 1 7 7 7 1 Spt20 family Caldesmon PF02029.15 CDI74542.1 - 0.008 15.0 40.6 0.0085 14.9 40.6 1.1 1 0 0 1 1 1 1 Caldesmon Exonuc_VII_L PF02601.15 CDI74542.1 - 0.011 15.3 50.0 0.013 15.0 50.0 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit PAT1 PF09770.9 CDI74542.1 - 0.025 12.9 73.3 0.029 12.7 73.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PNISR PF15996.5 CDI74542.1 - 0.14 12.4 53.6 0.2 11.9 53.6 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR CDC45 PF02724.14 CDI74542.1 - 0.17 10.2 42.9 0.21 9.8 42.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.6 CDI74542.1 - 0.43 10.2 45.2 0.58 9.7 45.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Membralin PF09746.9 CDI74542.1 - 0.5 9.3 29.1 0.66 9.0 29.1 1.2 1 0 0 1 1 1 0 Tumour-associated protein PA26 PF04636.13 CDI74542.1 - 0.88 8.4 31.9 1.1 8.0 31.9 1.4 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Macoilin PF09726.9 CDI74542.1 - 0.98 7.9 48.0 1.2 7.6 48.0 1.1 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 CDI74542.1 - 1.7 5.6 56.3 2 5.5 56.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 CDI74542.1 - 1.9 7.4 49.6 2.2 7.2 49.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 SAGA-Tad1 PF12767.7 CDI74542.1 - 1.9 8.2 40.3 2.7 7.7 40.3 1.3 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit LAP1C PF05609.12 CDI74542.1 - 2.2 7.3 47.3 2.7 7.0 47.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Raftlin PF15250.6 CDI74542.1 - 4 6.1 38.1 4.5 5.9 38.1 1.2 1 0 0 1 1 1 0 Raftlin RIFIN PF02009.16 CDI74542.1 - 4.1 7.2 35.0 5.1 6.9 35.0 1.1 1 0 0 1 1 1 0 Rifin DUF2151 PF10221.9 CDI74542.1 - 6.8 5.2 29.2 8.2 4.9 29.2 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Draxin PF15550.6 CDI74542.1 - 6.9 6.5 36.1 8.7 6.1 36.1 1.1 1 0 0 1 1 1 0 Draxin SAPS PF04499.15 CDI74542.1 - 9.3 4.9 35.6 13 4.4 35.6 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TFIIA PF03153.13 CDI74543.1 - 0.029 14.4 37.4 0.042 13.9 37.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SWI-SNF_Ssr4 PF08549.10 CDI74543.1 - 0.034 12.8 28.3 0.044 12.4 28.3 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) SOBP PF15279.6 CDI74543.1 - 0.038 14.6 21.6 0.047 14.3 21.6 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Sin_N PF04801.13 CDI74543.1 - 0.05 12.8 26.1 0.061 12.5 26.1 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region Activator_LAG-3 PF11498.8 CDI74543.1 - 0.056 12.4 39.9 0.079 11.9 39.9 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Mcm10 PF09332.11 CDI74543.1 - 0.11 11.9 19.6 0.14 11.6 19.6 1.3 1 0 0 1 1 1 0 Mcm10 replication factor GREB1 PF15782.5 CDI74543.1 - 0.16 9.0 27.0 0.2 8.8 27.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hamartin PF04388.12 CDI74543.1 - 0.27 9.9 22.2 0.31 9.7 22.2 1.0 1 0 0 1 1 1 0 Hamartin protein AF-4 PF05110.13 CDI74543.1 - 0.45 8.5 34.4 0.64 8.0 34.4 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF966 PF06136.13 CDI74543.1 - 0.47 10.1 23.1 0.6 9.8 23.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Asp-B-Hydro_N PF05279.11 CDI74543.1 - 0.89 9.6 17.3 1.1 9.3 17.3 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region PAT1 PF09770.9 CDI74543.1 - 1 7.6 28.2 1.1 7.4 28.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 CDI74543.1 - 1.2 8.1 20.6 1.5 7.8 20.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Mitofilin PF09731.9 CDI74543.1 - 1.4 7.6 31.7 1.7 7.4 31.7 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Utp14 PF04615.13 CDI74543.1 - 2.3 6.7 27.5 2.9 6.4 27.5 1.0 1 0 0 1 1 1 0 Utp14 protein AAA_23 PF13476.6 CDI74543.1 - 3.5 8.1 20.0 4.8 7.6 20.0 1.2 1 0 0 1 1 1 0 AAA domain Glyco_transf_41 PF13844.6 CDI74543.1 - 3.5 6.0 8.9 3.9 5.8 8.9 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 SR-25 PF10500.9 CDI74543.1 - 5.9 6.4 37.0 1.1 8.9 31.0 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein CDK5_activator PF03261.15 CDI74543.1 - 7.5 6.0 20.1 9.2 5.7 20.1 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF3584 PF12128.8 CDI74543.1 - 8 3.8 30.5 8.8 3.7 30.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Nrap PF03813.14 CDI74544.1 - 5.5e-11 42.7 0.5 8.6e-11 42.1 0.5 1.5 1 1 0 1 1 1 1 Nrap protein domain 1 MTBP_C PF14920.6 CDI74545.1 - 0.018 14.8 1.2 0.026 14.3 1.2 1.2 1 0 0 1 1 1 0 MDM2-binding Ydr279_N PF17745.1 CDI74545.1 - 0.045 14.0 0.0 0.083 13.2 0.0 1.5 1 0 0 1 1 1 0 Ydr279p protein triple barrel domain Apt1 PF10351.9 CDI74546.1 - 0.0056 15.6 16.1 0.0056 15.6 16.1 2.0 2 0 0 2 2 2 1 Golgi-body localisation protein domain Pex14_N PF04695.13 CDI74546.1 - 0.006 17.3 30.5 0.006 17.3 30.5 3.2 2 1 0 2 2 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF755 PF05501.11 CDI74546.1 - 0.012 15.9 18.1 0.012 15.9 18.1 4.1 2 2 1 3 3 1 0 Domain of unknown function (DUF755) Presenilin PF01080.17 CDI74546.1 - 0.061 12.1 48.3 0.076 11.8 4.9 2.1 2 0 0 2 2 2 0 Presenilin PTPRCAP PF15713.5 CDI74546.1 - 0.074 13.3 33.8 0.071 13.4 23.7 2.4 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated BUD22 PF09073.10 CDI74546.1 - 0.095 12.0 36.3 0.17 11.2 36.3 1.3 1 1 0 1 1 1 0 BUD22 SWI-SNF_Ssr4 PF08549.10 CDI74546.1 - 0.17 10.5 27.9 0.3 9.7 17.9 2.0 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) Plasmodium_Vir PF05795.11 CDI74546.1 - 0.17 11.3 29.3 0.44 9.9 14.4 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Vfa1 PF08432.10 CDI74546.1 - 0.43 10.9 38.2 1.6 9.0 0.8 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF3807 PF12720.7 CDI74546.1 - 0.54 10.5 49.4 0.26 11.5 35.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) SpoIIP PF07454.11 CDI74546.1 - 0.79 9.1 35.7 0.36 10.2 25.3 2.5 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF2052 PF09747.9 CDI74546.1 - 1.1 9.3 38.0 2.2 8.4 1.0 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) ASD2 PF08687.11 CDI74546.1 - 1.6 8.3 41.4 1.9 8.0 6.1 2.1 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 HABP4_PAI-RBP1 PF04774.15 CDI74546.1 - 1.6 9.6 29.4 0.31 11.9 22.0 2.4 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family RR_TM4-6 PF06459.12 CDI74546.1 - 1.7 8.4 39.2 0.96 9.2 31.0 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Miga PF10265.9 CDI74546.1 - 1.8 7.5 37.7 0.062 12.3 10.8 2.1 2 0 0 2 2 2 0 Mitoguardin Endostatin PF06482.11 CDI74546.1 - 2.2 7.7 32.5 0.68 9.4 23.3 2.2 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin DDRGK PF09756.9 CDI74546.1 - 3 7.4 45.0 3.7 7.1 40.3 2.1 2 0 0 2 2 2 0 DDRGK domain SURF6 PF04935.12 CDI74546.1 - 3.8 7.3 48.0 2 8.1 32.8 2.2 2 0 0 2 2 2 0 Surfeit locus protein 6 DUF3292 PF11696.8 CDI74546.1 - 3.9 5.7 24.5 1.2 7.4 19.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) Gti1_Pac2 PF09729.9 CDI74546.1 - 4.1 7.4 40.6 5.7 7.0 25.1 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family CDC45 PF02724.14 CDI74546.1 - 6 5.0 36.7 2.3 6.4 1.6 2.0 2 0 0 2 2 2 0 CDC45-like protein PNISR PF15996.5 CDI74546.1 - 6.2 7.0 49.7 0.94 9.7 29.4 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR MMM1 PF10296.9 CDI74546.1 - 6.8 5.6 29.0 3.7 6.5 2.8 2.3 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 DUF5427 PF10310.9 CDI74546.1 - 6.9 5.5 44.5 3.4 6.5 29.5 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5427) CobT PF06213.12 CDI74547.1 - 0.12 11.7 36.5 0.13 11.7 36.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SpoIIP PF07454.11 CDI74547.1 - 0.43 10.0 27.4 0.57 9.6 27.4 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RR_TM4-6 PF06459.12 CDI74547.1 - 0.57 10.0 29.1 0.59 9.9 29.1 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI74547.1 - 0.69 8.6 34.9 0.72 8.5 34.9 1.0 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 CDI74547.1 - 0.7 9.1 13.8 0.72 9.0 13.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2828 PF11443.8 CDI74547.1 - 0.95 7.5 25.2 0.94 7.5 25.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF5427 PF10310.9 CDI74547.1 - 1.3 7.9 30.4 1.4 7.8 30.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) HCO3_cotransp PF00955.21 CDI74547.1 - 1.3 7.7 12.4 1.4 7.7 12.4 1.0 1 0 0 1 1 1 0 HCO3- transporter family Baculo_PP31 PF05311.11 CDI74547.1 - 1.5 8.3 22.9 1.7 8.1 22.9 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) PTPRCAP PF15713.5 CDI74547.1 - 1.5 9.1 27.0 1.6 9.0 27.0 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated PPP4R2 PF09184.11 CDI74547.1 - 1.5 8.3 17.6 1.5 8.3 17.6 1.0 1 0 0 1 1 1 0 PPP4R2 Pox_Ag35 PF03286.14 CDI74547.1 - 1.5 8.5 20.7 1.7 8.4 20.7 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TCP PF03634.13 CDI74547.1 - 1.6 9.3 28.7 1.8 9.1 28.7 1.1 1 0 0 1 1 1 0 TCP family transcription factor CDC45 PF02724.14 CDI74547.1 - 1.9 6.7 24.2 1.8 6.7 24.2 1.1 1 0 0 1 1 1 0 CDC45-like protein STAC2_u1 PF16664.5 CDI74547.1 - 2 8.9 20.7 2.6 8.5 20.7 1.2 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 PA26 PF04636.13 CDI74547.1 - 2.4 7.0 22.7 2.6 6.8 22.7 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Endostatin PF06482.11 CDI74547.1 - 2.4 7.5 26.8 2.6 7.4 26.8 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin YABBY PF04690.13 CDI74547.1 - 2.6 8.6 22.9 2.9 8.4 22.9 1.1 1 0 0 1 1 1 0 YABBY protein Serinc PF03348.15 CDI74547.1 - 2.9 6.7 16.7 3.6 6.4 16.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF913 PF06025.12 CDI74547.1 - 3.7 6.4 19.4 3.6 6.5 19.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SID-1_RNA_chan PF13965.6 CDI74547.1 - 4.1 5.7 14.2 4.1 5.7 14.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PIP5K PF01504.18 CDI74547.1 - 4.3 6.5 21.9 5.2 6.2 21.9 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2052 PF09747.9 CDI74547.1 - 5.5 7.1 29.7 6.1 6.9 29.7 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CCSAP PF15748.5 CDI74547.1 - 6 7.0 35.5 6.5 6.8 35.5 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 CDI74547.1 - 6.3 5.7 30.1 6.3 5.7 30.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI74547.1 - 7.5 4.7 47.5 7.9 4.6 47.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1168 PF06658.12 CDI74547.1 - 8.8 6.2 34.0 10 5.9 34.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) DUF2370 PF10176.9 CDI74547.1 - 8.9 5.9 15.0 9 5.9 15.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF2126 PF09899.9 CDI74547.1 - 9.2 4.2 22.7 10 4.0 22.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) NPR3 PF03666.13 CDI74547.1 - 9.3 4.9 30.0 10 4.8 30.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FAM60A PF15396.6 CDI74547.1 - 9.9 6.1 24.0 11 5.9 24.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SR-25 PF10500.9 CDI74548.1 - 0.002 17.8 12.1 0.002 17.8 12.1 3.5 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI74548.1 - 0.004 17.2 12.2 0.004 17.2 12.2 3.3 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI74548.1 - 0.0096 15.6 12.1 0.0096 15.6 12.1 3.7 2 1 1 3 3 3 1 Spt20 family HEAT PF02985.22 CDI74548.1 - 0.011 15.9 2.4 0.1 12.9 0.1 3.9 4 0 0 4 4 4 0 HEAT repeat SOBP PF15279.6 CDI74548.1 - 0.35 11.4 35.8 1.3 9.6 20.0 2.4 2 0 0 2 2 2 0 Sine oculis-binding protein Apt1 PF10351.9 CDI74548.1 - 0.75 8.6 28.6 0.74 8.6 1.6 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain Peptidase_S64 PF08192.11 CDI74548.1 - 1.5 7.2 33.4 0.36 9.2 0.9 2.1 2 0 0 2 2 2 0 Peptidase family S64 Conotoxin PF02950.17 CDI74549.1 - 0.0013 19.7 6.2 0.0013 19.7 6.2 2.2 1 1 1 2 2 2 1 Conotoxin DUF1180 PF06679.12 CDI74549.1 - 0.0013 19.2 10.2 0.0016 18.9 10.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) V_ATPase_I PF01496.19 CDI74549.1 - 0.0074 14.3 15.5 0.0079 14.2 15.5 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family O-antigen_lig PF13425.6 CDI74549.1 - 0.011 14.6 10.8 0.011 14.5 10.8 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein TRAP_alpha PF03896.16 CDI74549.1 - 0.024 13.9 7.0 0.027 13.7 7.0 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CobT PF06213.12 CDI74549.1 - 0.062 12.7 23.3 0.073 12.4 23.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CRA PF06589.11 CDI74549.1 - 0.064 13.4 1.9 0.1 12.7 1.9 1.4 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) DUF4692 PF15763.5 CDI74549.1 - 0.1 13.1 11.0 0.11 13.0 11.0 1.0 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Phage_Gp23 PF10669.9 CDI74549.1 - 0.12 12.7 7.5 0.13 12.6 7.5 1.1 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Scs3p PF10261.9 CDI74549.1 - 0.14 11.6 6.1 0.18 11.3 6.1 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM ETRAMP PF09716.10 CDI74549.1 - 0.14 12.2 0.2 0.28 11.3 0.0 1.5 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) stn_TNFRSF12A PF12191.8 CDI74549.1 - 0.22 11.8 0.4 0.34 11.1 0.2 1.4 1 1 1 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain NicO PF03824.16 CDI74549.1 - 0.36 10.1 0.9 0.37 10.1 0.9 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein CLN3 PF02487.17 CDI74549.1 - 0.47 9.4 14.5 0.49 9.4 14.5 1.1 1 0 0 1 1 1 0 CLN3 protein RED_N PF07808.13 CDI74549.1 - 0.49 9.9 21.0 0.57 9.7 21.0 1.2 1 0 0 1 1 1 0 RED-like protein N-terminal region SID-1_RNA_chan PF13965.6 CDI74549.1 - 0.55 8.6 10.9 0.56 8.5 10.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CCDC53 PF10152.9 CDI74549.1 - 0.67 10.4 20.3 0.91 9.9 20.3 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex FAM209 PF15206.6 CDI74549.1 - 0.68 9.7 8.7 0.1 12.4 3.8 1.8 1 1 1 2 2 2 0 FAM209 family Mucin PF01456.17 CDI74549.1 - 0.81 9.7 8.3 1.4 8.9 8.3 1.4 1 1 0 1 1 1 0 Mucin-like glycoprotein FAM176 PF14851.6 CDI74549.1 - 0.82 9.3 15.3 1.6 8.4 15.3 1.5 1 1 0 1 1 1 0 FAM176 family DUF3357 PF11837.8 CDI74549.1 - 0.87 10.1 7.8 15 6.1 7.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) Zip PF02535.22 CDI74549.1 - 1.2 8.3 10.6 1.2 8.3 10.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Endonuc_Holl PF10107.9 CDI74549.1 - 1.2 9.0 14.2 1.4 8.8 14.2 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase OAD_gamma PF04277.13 CDI74549.1 - 1.6 9.4 7.2 24 5.6 7.2 2.2 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain BORG_CEP PF14957.6 CDI74549.1 - 1.7 9.8 16.9 1.9 9.7 16.9 1.1 1 0 0 1 1 1 0 Cdc42 effector GRP PF07172.11 CDI74549.1 - 1.7 9.4 10.5 25 5.6 10.5 2.1 1 1 0 1 1 1 0 Glycine rich protein family Presenilin PF01080.17 CDI74549.1 - 1.7 7.3 29.6 1.9 7.1 29.6 1.0 1 0 0 1 1 1 0 Presenilin Serinc PF03348.15 CDI74549.1 - 1.8 7.4 11.2 2.2 7.1 11.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2828 PF11443.8 CDI74549.1 - 2 6.4 19.9 2.2 6.3 19.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CBP_BcsG PF11658.8 CDI74549.1 - 2 6.7 15.0 2.4 6.4 15.0 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG K_trans PF02705.16 CDI74549.1 - 2.3 6.6 4.1 2.3 6.6 4.1 1.0 1 0 0 1 1 1 0 K+ potassium transporter DUF2370 PF10176.9 CDI74549.1 - 2.5 7.7 10.3 2.7 7.6 10.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) MSP1a PF11670.8 CDI74549.1 - 3 7.1 7.0 0.66 9.2 3.7 1.5 1 1 1 2 2 2 0 Major surface protein 1a (MSP1a) CSG2 PF16965.5 CDI74549.1 - 3.1 6.6 11.9 3.5 6.5 11.9 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator PepSY_2 PF13670.6 CDI74549.1 - 4.8 7.3 10.0 1.2e+02 2.8 10.0 2.3 1 1 0 1 1 1 0 Peptidase propeptide and YPEB domain YABBY PF04690.13 CDI74549.1 - 5.2 7.6 17.1 6.7 7.3 17.1 1.2 1 0 0 1 1 1 0 YABBY protein PepSY_TM PF03929.16 CDI74549.1 - 5.6 6.6 8.8 7.2 6.2 8.8 1.3 1 0 0 1 1 1 0 PepSY-associated TM region DUF2464 PF10240.9 CDI74549.1 - 6.5 6.2 15.6 7.9 6.0 15.6 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 Tmemb_161AB PF10268.9 CDI74549.1 - 6.6 5.2 8.5 12 4.5 8.5 1.6 1 1 0 1 1 1 0 Predicted transmembrane protein 161AB Tmp39 PF10271.9 CDI74549.1 - 6.7 5.6 5.8 6.6 5.6 5.8 1.0 1 0 0 1 1 1 0 Putative transmembrane protein Mem_trans PF03547.18 CDI74549.1 - 7.2 4.9 10.5 7.2 4.9 10.5 1.0 1 0 0 1 1 1 0 Membrane transport protein XPG_N PF00752.17 CDI74550.1 - 6.7e-08 32.9 3.4 5.2e-07 30.1 3.4 2.3 1 1 0 1 1 1 1 XPG N-terminal domain DUF5523 PF17661.1 CDI74550.1 - 0.0029 17.3 0.6 0.0035 17.1 0.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5523) RskA PF10099.9 CDI74550.1 - 0.0042 17.4 9.0 0.005 17.2 9.0 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Methyltransf_32 PF13679.6 CDI74550.1 - 0.0055 16.7 4.0 0.0065 16.5 4.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain CPSF100_C PF13299.6 CDI74550.1 - 0.0068 16.6 3.8 0.008 16.4 3.8 1.0 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal CD20 PF04103.15 CDI74550.1 - 0.007 16.5 0.5 0.0097 16.0 0.5 1.2 1 0 0 1 1 1 1 CD20-like family Pex14_N PF04695.13 CDI74550.1 - 0.013 16.2 6.8 0.013 16.1 6.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SurA_N_2 PF13623.6 CDI74550.1 - 0.014 15.3 10.1 0.017 15.0 10.1 1.1 1 0 0 1 1 1 0 SurA N-terminal domain TFIIA PF03153.13 CDI74550.1 - 0.014 15.4 17.1 0.015 15.4 17.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MTP18 PF10558.9 CDI74550.1 - 0.026 14.5 1.2 0.028 14.4 1.2 1.1 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) EIIBC-GUT_N PF03612.14 CDI74550.1 - 0.026 14.3 3.4 0.03 14.1 3.4 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4834 PF16118.5 CDI74550.1 - 0.029 15.3 3.1 0.036 15.0 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) AIF_C PF14721.6 CDI74550.1 - 0.041 14.2 3.4 0.049 14.0 3.4 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF3824 PF12868.7 CDI74550.1 - 0.062 14.0 6.3 0.08 13.6 6.3 1.1 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Orf78 PF06024.12 CDI74550.1 - 0.063 13.6 2.6 0.082 13.2 2.6 1.2 1 0 0 1 1 1 0 Orf78 (ac78) MTABC_N PF16185.5 CDI74550.1 - 0.068 12.7 0.6 0.084 12.4 0.6 1.2 1 0 0 1 1 1 0 Mitochondrial ABC-transporter N-terminal five TM region DUF2512 PF10710.9 CDI74550.1 - 0.1 12.2 0.7 0.13 11.9 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2512) Connexin PF00029.19 CDI74550.1 - 0.12 12.2 2.6 0.13 12.0 2.6 1.1 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 CDI74550.1 - 0.16 10.7 3.8 0.18 10.5 3.8 1.1 1 0 0 1 1 1 0 Presenilin OmpH PF03938.14 CDI74550.1 - 0.16 12.3 18.3 0.21 11.9 18.3 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Serinc PF03348.15 CDI74550.1 - 0.16 10.8 2.7 0.19 10.7 2.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF3915 PF13054.6 CDI74550.1 - 0.17 11.9 0.5 0.26 11.3 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Suf PF05843.14 CDI74550.1 - 0.18 11.8 7.5 0.2 11.6 7.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF5421 PF17458.2 CDI74550.1 - 0.32 10.3 8.7 0.38 10.1 8.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5421) Gastrin PF00918.17 CDI74550.1 - 0.34 11.9 6.6 0.4 11.7 6.6 1.2 1 0 0 1 1 1 0 Gastrin/cholecystokinin family Glt_symporter PF03616.14 CDI74550.1 - 0.41 9.3 2.4 0.5 9.0 2.4 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter R_equi_Vir PF05526.11 CDI74550.1 - 0.5 10.2 5.1 0.63 9.9 5.1 1.2 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Spt20 PF12090.8 CDI74550.1 - 0.73 9.4 23.0 0.88 9.1 23.0 1.1 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 CDI74550.1 - 0.75 8.7 17.9 0.85 8.5 17.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Kei1 PF08552.11 CDI74550.1 - 9.3 6.1 10.2 9 6.1 9.4 1.4 1 1 1 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Sin_N PF04801.13 CDI74551.1 - 1.5e-48 166.1 24.4 1.5e-48 166.1 24.4 3.0 1 1 1 2 2 2 1 Sin-like protein conserved region Afi1 PF07792.12 CDI74551.1 - 0.01 16.3 18.5 1.2 9.6 4.2 3.7 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MAT1 PF06391.13 CDI74551.1 - 0.2 11.5 32.6 0.02 14.8 7.9 3.4 3 0 0 3 3 3 0 CDK-activating kinase assembly factor MAT1 DUF913 PF06025.12 CDI74551.1 - 0.35 9.8 23.4 0.081 11.9 10.9 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) RRN3 PF05327.11 CDI74551.1 - 2.1 6.8 17.6 0.11 11.0 9.0 2.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 TFB6 PF17110.5 CDI74551.1 - 3 7.6 14.9 1.7 8.4 7.0 2.6 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH GOLD_2 PF13897.6 CDI74551.1 - 9 6.8 12.6 3.1 8.3 6.5 2.9 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking Ni_hydr_CYTB PF01292.20 CDI74552.1 - 0.2 11.2 1.3 8.8 5.9 0.1 3.4 2 1 1 3 3 3 0 Prokaryotic cytochrome b561 Orf78 PF06024.12 CDI74552.1 - 0.38 11.1 0.0 0.38 11.1 0.0 5.3 4 2 0 4 4 4 0 Orf78 (ac78) Papilloma_E5 PF03025.14 CDI74552.1 - 1.8 8.8 8.8 13 6.1 3.2 2.3 2 0 0 2 2 2 0 Papillomavirus E5 Bystin PF05291.11 CDI74553.1 - 1.8e-112 375.4 1.1 2.6e-112 374.9 1.1 1.2 1 0 0 1 1 1 1 Bystin Ribosomal_L36e PF01158.18 CDI74554.1 - 5e-37 126.0 4.4 6.6e-37 125.7 4.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L36e RSS_P20 PF11757.8 CDI74555.1 - 3.3 8.2 5.7 8.8 6.8 5.7 1.7 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like N-terminal domain Golgin_A5 PF09787.9 CDI74556.1 - 0.0029 17.1 23.3 0.0029 17.1 23.3 3.5 2 1 1 3 3 3 2 Golgin subfamily A member 5 Sugarporin_N PF11471.8 CDI74556.1 - 0.01 15.8 4.2 0.01 15.8 4.2 5.5 6 0 0 6 6 6 0 Maltoporin periplasmic N-terminal extension SOGA PF11365.8 CDI74556.1 - 0.041 15.0 2.6 0.041 15.0 2.6 5.4 3 1 1 5 5 5 0 Protein SOGA TFIIA PF03153.13 CDI74556.1 - 0.19 11.7 39.4 0.36 10.8 15.5 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF5527 PF17665.1 CDI74556.1 - 0.51 9.9 4.2 12 5.5 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5527) GAS PF13851.6 CDI74556.1 - 4.2 6.7 64.2 0.1 12.0 21.4 3.7 2 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding FbpA PF05833.11 CDI74557.1 - 0.019 13.8 11.2 0.019 13.8 11.2 1.0 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) DUF3813 PF12758.7 CDI74557.1 - 0.044 14.1 9.6 0.044 14.1 9.6 3.3 1 1 1 2 2 1 0 Protein of unknown function (DUF3813) DUF935 PF06074.12 CDI74557.1 - 0.075 11.8 7.3 0.083 11.6 7.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF935) MAT1 PF06391.13 CDI74557.1 - 0.075 12.9 14.4 0.087 12.6 14.4 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 OrsD PF12013.8 CDI74557.1 - 0.32 11.5 11.6 0.39 11.2 11.6 1.1 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D Cauli_AT PF03233.13 CDI74557.1 - 0.35 10.8 3.5 0.38 10.7 3.5 1.0 1 0 0 1 1 1 0 Aphid transmission protein TUDOR PF00567.24 CDI74557.1 - 0.36 10.9 8.9 1.8 8.6 4.5 2.0 1 1 1 2 2 2 0 Tudor domain 7tm_7 PF08395.12 CDI74557.1 - 0.44 9.7 15.6 0.51 9.5 15.6 1.0 1 0 0 1 1 1 0 7tm Chemosensory receptor YabA PF06156.13 CDI74557.1 - 0.55 10.9 13.7 0.66 10.7 13.7 1.1 1 0 0 1 1 1 0 Initiation control protein YabA Mod_r PF07200.13 CDI74557.1 - 0.87 9.7 26.6 1.1 9.3 26.6 1.0 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein RRP36 PF06102.12 CDI74557.1 - 1.3 9.0 14.7 1.5 8.8 14.7 1.0 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 DUF4407 PF14362.6 CDI74557.1 - 1.4 8.2 13.6 1.5 8.1 13.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3589 PF12141.8 CDI74557.1 - 1.5 7.3 10.6 1.7 7.1 10.6 1.0 1 0 0 1 1 1 0 Beta-mannosyltransferases CENP-O PF09496.10 CDI74557.1 - 1.9 8.4 10.8 2.1 8.3 10.8 1.0 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component LON_substr_bdg PF02190.16 CDI74557.1 - 2 8.2 8.4 2.4 8.0 8.4 1.2 1 0 0 1 1 1 0 ATP-dependent protease La (LON) substrate-binding domain DUF4446 PF14584.6 CDI74557.1 - 2.2 8.2 9.4 2.7 8.0 9.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF2367 PF10164.9 CDI74557.1 - 2.5 8.7 7.9 4.2 7.9 7.9 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) Exonuc_VII_L PF02601.15 CDI74557.1 - 2.5 7.6 17.1 2.9 7.4 17.1 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Plk4_PB2 PF18409.1 CDI74557.1 - 2.7 8.7 8.8 3.3 8.5 8.8 1.1 1 0 0 1 1 1 0 Polo-like Kinase 4 Polo Box 2 GvpL_GvpF PF06386.11 CDI74557.1 - 2.8 7.8 11.8 3.3 7.6 11.8 1.0 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF YueH PF14166.6 CDI74557.1 - 2.9 7.8 8.6 16 5.4 8.6 1.9 1 1 0 1 1 1 0 YueH-like protein DUF4301 PF14134.6 CDI74557.1 - 3.1 6.5 11.7 3.6 6.3 11.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4301) DUF702 PF05142.12 CDI74557.1 - 3.2 8.2 7.8 4.9 7.6 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) FliP PF00813.20 CDI74557.1 - 4.6 7.1 8.6 5.5 6.8 8.6 1.1 1 0 0 1 1 1 0 FliP family TFIIA PF03153.13 CDI74557.1 - 4.9 7.0 32.1 5.4 6.9 32.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MCU PF04678.13 CDI74557.1 - 5.5 7.1 11.6 6.8 6.8 11.6 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter BBS1 PF14779.6 CDI74557.1 - 6.4 6.1 10.0 6.7 6.1 10.0 1.0 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 FUSC PF04632.12 CDI74557.1 - 6.5 5.2 12.0 7.1 5.0 12.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family PRKCSH-like PF12999.7 CDI74557.1 - 8.6 6.1 8.6 10 5.9 8.6 1.0 1 0 0 1 1 1 0 Glucosidase II beta subunit-like AAA_23 PF13476.6 CDI74557.1 - 10 6.6 21.0 12 6.3 21.0 1.2 1 0 0 1 1 1 0 AAA domain Spt20 PF12090.8 CDI74558.1 - 0.0023 17.6 60.7 0.015 14.9 19.2 2.6 2 0 0 2 2 2 2 Spt20 family EIF4E-T PF10477.9 CDI74558.1 - 0.04 12.8 27.6 0.054 12.3 27.6 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E SR-25 PF10500.9 CDI74558.1 - 0.12 12.0 28.4 0.41 10.2 0.1 3.1 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein PAP_RNA-bind PF04926.15 CDI74558.1 - 0.27 10.8 14.2 0.11 12.1 0.6 2.3 2 0 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain Eapp_C PF10238.9 CDI74558.1 - 1.3 9.1 21.5 0.92 9.6 2.3 2.4 2 0 0 2 2 2 0 E2F-associated phosphoprotein EOS1 PF12326.8 CDI74558.1 - 2 8.3 11.7 2.8 7.9 1.4 2.2 2 0 0 2 2 2 0 N-glycosylation protein Peptidase_S49_N PF08496.10 CDI74558.1 - 2.4 8.2 20.3 5.7 7.0 10.7 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal G0-G1_switch_2 PF15103.6 CDI74558.1 - 2.9 8.4 14.3 3.5 8.1 1.3 2.7 2 0 0 2 2 2 0 G0/G1 switch protein 2 DUF2072 PF09845.9 CDI74558.1 - 3 8.1 12.3 2.9 8.1 5.1 2.3 2 0 0 2 2 2 0 Zn-ribbon containing protein Pet20 PF08692.10 CDI74558.1 - 4.6 8.0 13.6 4.1 8.1 1.3 2.3 2 0 0 2 2 2 0 Mitochondrial protein Pet20 NPR1_interact PF15699.5 CDI74558.1 - 5.6 7.6 19.7 1.2 9.7 0.9 2.6 2 0 0 2 2 2 0 NPR1 interacting Stig1 PF04885.13 CDI74558.1 - 6.1 7.3 14.3 1.7 9.1 1.8 2.5 2 0 0 2 2 2 0 Stigma-specific protein, Stig1 Connexin PF00029.19 CDI74558.1 - 7.3 6.3 16.7 5.8 6.6 1.0 2.1 2 0 0 2 2 2 0 Connexin MIF4G_like_2 PF09090.11 CDI74559.1 - 3e-08 33.5 0.0 3e-08 33.5 0.0 3.0 3 0 0 3 3 3 2 MIF4G like SUIM_assoc PF16619.5 CDI74561.1 - 0.00086 19.3 0.0 0.0014 18.6 0.0 1.4 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Rubis-subs-bind PF09273.11 CDI74561.1 - 0.0012 19.5 3.1 0.0028 18.4 3.1 1.7 1 1 0 1 1 1 1 Rubisco LSMT substrate-binding SR-25 PF10500.9 CDI74563.1 - 6.1e-07 29.3 39.8 6.5e-05 22.7 17.6 2.1 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein Utp14 PF04615.13 CDI74563.1 - 0.0013 17.4 17.5 0.0016 17.1 17.5 1.1 1 0 0 1 1 1 1 Utp14 protein CDK2AP PF09806.9 CDI74563.1 - 0.016 15.3 34.6 0.21 11.7 3.1 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein CCDC106 PF15794.5 CDI74563.1 - 0.13 11.9 33.6 0.036 13.8 19.1 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 SURF2 PF05477.11 CDI74563.1 - 1.1 8.8 19.9 1.5 8.5 15.7 2.1 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) SID-1_RNA_chan PF13965.6 CDI74563.1 - 1.3 7.3 7.9 1.8 6.8 7.9 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CCSAP PF15748.5 CDI74563.1 - 3 8.0 37.2 6.7 6.8 14.8 2.2 1 1 1 2 2 2 0 Centriole, cilia and spindle-associated Gti1_Pac2 PF09729.9 CDI74563.1 - 3.7 7.6 22.9 1.8 8.6 15.4 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family MIF4G_like_2 PF09090.11 CDI74564.1 - 0.0079 15.7 14.5 0.0094 15.5 14.5 1.0 1 0 0 1 1 1 1 MIF4G like CDC45 PF02724.14 CDI74564.1 - 0.014 13.7 17.8 0.014 13.7 17.8 1.0 1 0 0 1 1 1 0 CDC45-like protein LAP1C PF05609.12 CDI74564.1 - 0.14 11.3 27.8 0.14 11.2 27.8 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CCSAP PF15748.5 CDI74564.1 - 0.16 12.1 29.5 0.21 11.8 29.5 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated RR_TM4-6 PF06459.12 CDI74564.1 - 0.22 11.3 23.6 0.29 10.9 23.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI74564.1 - 0.4 9.4 29.4 0.5 9.1 29.4 1.2 1 0 0 1 1 1 0 Presenilin BORG_CEP PF14957.6 CDI74564.1 - 0.41 11.8 16.2 0.55 11.4 16.2 1.3 1 0 0 1 1 1 0 Cdc42 effector XAP5 PF04921.14 CDI74564.1 - 0.48 10.2 18.1 0.62 9.8 18.1 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator Endostatin PF06482.11 CDI74564.1 - 0.62 9.5 20.5 0.78 9.2 20.5 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin UPF0564 PF10595.9 CDI74564.1 - 0.83 8.6 33.4 0.98 8.4 33.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 DUF572 PF04502.13 CDI74564.1 - 0.91 9.1 21.5 1.1 8.8 21.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Spc7_N PF15402.6 CDI74564.1 - 1.1 7.5 24.8 1.1 7.4 24.8 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Apt1 PF10351.9 CDI74564.1 - 1.4 7.7 17.7 1.6 7.5 17.7 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain ALMT PF11744.8 CDI74564.1 - 1.4 7.6 16.8 1.6 7.5 16.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PA26 PF04636.13 CDI74564.1 - 1.5 7.7 18.4 1.7 7.5 18.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF2828 PF11443.8 CDI74564.1 - 1.6 6.7 20.0 2 6.4 20.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SLC12 PF03522.15 CDI74564.1 - 1.7 7.6 24.9 1.9 7.4 24.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Sec62 PF03839.16 CDI74564.1 - 1.8 8.0 16.9 2.2 7.8 16.9 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Plasmodium_Vir PF05795.11 CDI74564.1 - 2.5 7.4 13.7 3 7.2 13.7 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PAT1 PF09770.9 CDI74564.1 - 2.5 6.3 43.9 2.9 6.1 43.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PPP4R2 PF09184.11 CDI74564.1 - 2.5 7.6 14.5 3.4 7.2 14.5 1.2 1 0 0 1 1 1 0 PPP4R2 DUF3357 PF11837.8 CDI74564.1 - 3.1 8.3 12.5 11 6.5 3.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) Hamartin PF04388.12 CDI74564.1 - 3.2 6.3 23.5 3.8 6.1 23.5 1.0 1 0 0 1 1 1 0 Hamartin protein Lin-8 PF03353.15 CDI74564.1 - 3.7 7.0 27.4 4.5 6.7 27.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Activator_LAG-3 PF11498.8 CDI74564.1 - 3.9 6.4 70.8 4.3 6.2 70.8 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Membralin PF09746.9 CDI74564.1 - 3.9 6.4 14.7 4.3 6.3 14.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein RskA PF10099.9 CDI74564.1 - 4 7.7 39.4 0.64 10.3 19.6 2.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA XRN_M PF17846.1 CDI74564.1 - 4.8 6.0 16.2 5.6 5.8 16.2 1.3 1 0 0 1 1 1 0 Xrn1 helical domain GET2 PF08690.10 CDI74564.1 - 5.6 6.5 33.9 6.9 6.3 33.9 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 DUF5427 PF10310.9 CDI74564.1 - 7.3 5.4 34.1 11 4.9 34.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SAGA-Tad1 PF12767.7 CDI74564.1 - 7.4 6.2 22.6 9.1 5.9 22.6 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Spt20 PF12090.8 CDI74565.1 - 0.0059 16.3 31.3 0.0066 16.1 31.3 1.0 1 0 0 1 1 1 1 Spt20 family Pex14_N PF04695.13 CDI74565.1 - 0.058 14.0 14.2 0.065 13.9 14.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Hist_deacetyl PF00850.19 CDI74565.1 - 0.18 11.3 3.6 0.21 11.0 3.6 1.0 1 0 0 1 1 1 0 Histone deacetylase domain DUF2722 PF10846.8 CDI74565.1 - 0.22 10.4 25.9 0.24 10.3 25.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TERB2 PF15101.6 CDI74565.1 - 0.22 11.5 16.0 0.21 11.6 16.0 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TAF4 PF05236.14 CDI74565.1 - 0.26 11.0 15.5 0.3 10.8 15.5 1.0 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family CIAPIN1 PF05093.13 CDI74565.1 - 0.47 11.0 5.4 0.52 10.9 5.4 1.1 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis ABC2_membrane_2 PF12679.7 CDI74565.1 - 0.69 9.1 5.9 0.74 9.0 5.9 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein RIFIN PF02009.16 CDI74565.1 - 1 9.2 10.9 0.97 9.3 10.9 1.0 1 0 0 1 1 1 0 Rifin Med15 PF09606.10 CDI74565.1 - 1.1 7.9 27.1 1.1 7.8 27.1 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI74565.1 - 1.2 9.1 30.6 1.2 9.0 30.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Activator_LAG-3 PF11498.8 CDI74565.1 - 1.4 7.8 39.8 1.5 7.7 39.8 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 MPM1 PF17234.2 CDI74565.1 - 1.4 9.1 10.6 1.5 9.0 10.6 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 DUF702 PF05142.12 CDI74565.1 - 1.5 9.3 13.2 1.6 9.2 13.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Kinesin_assoc PF16183.5 CDI74565.1 - 1.6 8.8 4.3 1.6 8.8 4.3 1.0 1 0 0 1 1 1 0 Kinesin-associated BAT2_N PF07001.11 CDI74565.1 - 1.6 9.1 17.9 1.8 9.0 17.9 1.0 1 0 0 1 1 1 0 BAT2 N-terminus MCU PF04678.13 CDI74565.1 - 1.9 8.5 12.2 2.2 8.3 12.2 1.0 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Band_3_cyto PF07565.13 CDI74565.1 - 2.1 8.1 9.9 2.2 8.0 9.9 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Sec62 PF03839.16 CDI74565.1 - 2.4 7.6 7.3 2.5 7.6 7.3 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 TMEM51 PF15345.6 CDI74565.1 - 2.5 7.9 12.0 2.8 7.7 12.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 DUF2232 PF09991.9 CDI74565.1 - 2.6 7.2 4.8 2.9 7.0 4.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Membralin PF09746.9 CDI74565.1 - 2.8 6.9 6.1 3 6.8 6.1 1.0 1 0 0 1 1 1 0 Tumour-associated protein EPL1 PF10513.9 CDI74565.1 - 3.2 8.1 13.0 3.6 8.0 13.0 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like BRF1 PF07741.13 CDI74565.1 - 3.2 8.1 12.5 3.8 7.9 12.5 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain XRCC4 PF06632.12 CDI74565.1 - 3.5 6.4 12.2 3.7 6.3 12.2 1.0 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF2368 PF10166.9 CDI74565.1 - 3.8 7.1 15.2 4.5 6.9 15.2 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) Connexin PF00029.19 CDI74565.1 - 3.9 7.2 6.8 4.1 7.1 6.8 1.0 1 0 0 1 1 1 0 Connexin Rpp20 PF12328.8 CDI74565.1 - 4 7.4 11.1 4.8 7.2 11.1 1.1 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P V_ATPase_I PF01496.19 CDI74565.1 - 4.2 5.2 10.4 4.2 5.2 10.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-3_zeta PF05091.12 CDI74565.1 - 4.3 6.2 15.2 4.6 6.1 15.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CLN3 PF02487.17 CDI74565.1 - 4.4 6.3 8.9 4.3 6.3 8.9 1.0 1 0 0 1 1 1 0 CLN3 protein ALMT PF11744.8 CDI74565.1 - 4.4 6.0 8.2 4.5 6.0 8.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter UPF0560 PF10577.9 CDI74565.1 - 4.7 5.6 17.3 4.8 5.6 17.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DDHD PF02862.17 CDI74565.1 - 4.9 7.2 11.0 5.1 7.2 11.0 1.1 1 0 0 1 1 1 0 DDHD domain CPSF100_C PF13299.6 CDI74565.1 - 5.2 7.2 12.0 5.3 7.2 12.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Baculo_PP31 PF05311.11 CDI74565.1 - 5.3 6.5 10.0 5.3 6.4 10.0 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) EIIBC-GUT_N PF03612.14 CDI74565.1 - 5.3 6.7 10.5 5.7 6.6 10.5 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Suf PF05843.14 CDI74565.1 - 5.4 6.9 15.1 5.5 6.9 15.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 CDI74565.1 - 5.7 6.9 8.3 6 6.9 8.3 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GREB1 PF15782.5 CDI74565.1 - 7.2 3.6 12.4 7.3 3.6 12.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ctr PF04145.15 CDI74565.1 - 8.7 6.9 7.3 9.3 6.9 7.3 1.1 1 0 0 1 1 1 0 Ctr copper transporter family FTZ PF03867.14 CDI74565.1 - 9.3 5.7 14.2 12 5.4 14.2 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region CSG2 PF16965.5 CDI74565.1 - 9.5 5.1 6.1 9.7 5.0 6.1 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator SR-25 PF10500.9 CDI74566.1 - 0.0051 16.5 14.5 0.0051 16.5 14.5 4.1 1 1 3 4 4 4 1 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI74566.1 - 4.9 7.4 44.9 0.096 13.0 3.2 4.5 1 1 3 4 4 4 0 Anti-sigma-K factor rskA SPX PF03105.19 CDI74567.1 - 0.0013 18.7 14.6 0.0013 18.7 14.6 3.1 2 1 1 3 3 3 1 SPX domain SR-25 PF10500.9 CDI74567.1 - 0.014 15.0 20.1 0.014 15.0 20.1 3.7 3 1 1 4 4 4 0 Nuclear RNA-splicing-associated protein DUF4179 PF13786.6 CDI74567.1 - 0.02 15.3 0.0 0.02 15.3 0.0 5.1 3 2 0 4 4 4 0 Domain of unknown function (DUF4179) DUF2722 PF10846.8 CDI74567.1 - 0.063 12.2 0.0 0.063 12.2 0.0 5.1 1 1 3 4 4 4 0 Protein of unknown function (DUF2722) RAP1 PF07218.11 CDI74567.1 - 1.4 7.1 15.4 2 6.6 15.4 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Kinesin PF00225.23 CDI74568.1 - 1.2e-10 40.9 0.0 1.2e-10 40.9 0.0 2.6 2 1 1 3 3 3 1 Kinesin motor domain Nha1_C PF08619.10 CDI74568.1 - 0.0061 15.8 3.2 0.0061 15.8 3.2 2.7 2 1 1 3 3 3 1 Alkali metal cation/H+ antiporter Nha1 C terminus Microtub_bd PF16796.5 CDI74568.1 - 0.0083 16.1 2.3 0.012 15.5 0.0 2.2 2 0 0 2 2 2 1 Microtubule binding EPL1 PF10513.9 CDI74568.1 - 0.0085 16.5 3.0 0.0085 16.5 3.0 3.0 2 1 0 2 2 2 1 Enhancer of polycomb-like BAT2_N PF07001.11 CDI74568.1 - 0.11 13.0 41.4 0.037 14.5 15.6 3.3 3 0 0 3 3 3 0 BAT2 N-terminus DUF913 PF06025.12 CDI74568.1 - 0.57 9.1 14.8 0.5 9.3 5.2 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF3740 PF12548.8 CDI74568.1 - 0.88 10.0 11.4 1.1 9.7 3.8 2.7 2 1 1 3 3 3 0 Sulfatase protein DUF3408 PF11888.8 CDI74568.1 - 1.7 8.8 17.2 1.5 9.0 7.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3408) Spt5_N PF11942.8 CDI74568.1 - 3.8 8.5 16.0 11 7.1 7.8 2.6 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal Lin-8 PF03353.15 CDI74568.1 - 5.7 6.4 27.6 0.16 11.5 11.4 3.0 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist TFIIA PF03153.13 CDI74569.1 - 7.2e-07 29.6 46.6 8.1e-07 29.4 46.6 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit MAP7 PF05672.11 CDI74569.1 - 0.0037 17.0 34.8 0.0062 16.2 34.8 1.4 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family Exonuc_VII_L PF02601.15 CDI74569.1 - 0.017 14.7 21.1 0.021 14.4 21.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Hamartin PF04388.12 CDI74569.1 - 0.059 12.0 33.9 0.068 11.8 33.9 1.1 1 0 0 1 1 1 0 Hamartin protein PAT1 PF09770.9 CDI74569.1 - 0.073 11.3 41.5 0.085 11.1 41.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SOG2 PF10428.9 CDI74569.1 - 0.14 11.3 46.0 0.2 10.8 46.0 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein GREB1 PF15782.5 CDI74569.1 - 0.41 7.7 49.3 0.5 7.4 49.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer eIF-3_zeta PF05091.12 CDI74569.1 - 0.83 8.6 33.4 1.1 8.1 33.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_S49_N PF08496.10 CDI74569.1 - 2.1 8.4 17.3 4 7.5 17.3 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DDRGK PF09756.9 CDI74569.1 - 3.7 7.1 29.9 7.8 6.0 29.9 1.5 1 0 0 1 1 1 0 DDRGK domain Dicty_REP PF05086.12 CDI74569.1 - 5 5.0 35.8 6.5 4.6 35.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Asp-B-Hydro_N PF05279.11 CDI74569.1 - 6.5 6.7 21.5 1.2 9.2 17.9 1.7 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region SOBP PF15279.6 CDI74569.1 - 6.7 7.2 40.2 11 6.5 40.2 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein HemX PF04375.14 CDI74569.1 - 8 5.6 43.3 12 5.0 43.3 1.3 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase LAP1C PF05609.12 CDI74569.1 - 8.2 5.4 41.1 11 4.9 41.1 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDK5_activator PF03261.15 CDI74569.1 - 8.3 5.8 37.1 11 5.4 37.1 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein V_ATPase_I PF01496.19 CDI74570.1 - 0.00075 17.6 14.9 0.00075 17.6 14.9 5.9 5 1 1 6 6 6 2 V-type ATPase 116kDa subunit family ABC2_membrane_2 PF12679.7 CDI74570.1 - 0.13 11.5 0.0 0.13 11.5 0.0 7.8 5 3 1 6 6 6 0 ABC-2 family transporter protein Yae1_N PF09811.9 CDI74571.1 - 0.12 12.1 0.7 14 5.5 0.7 3.2 1 1 0 1 1 1 0 Essential protein Yae1, N terminal SR-25 PF10500.9 CDI74572.1 - 6.5e-07 29.2 55.4 0.00092 18.9 14.9 2.3 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein PAP1 PF08601.10 CDI74572.1 - 0.0035 17.1 13.2 0.0035 17.1 13.2 2.1 2 0 0 2 2 2 1 Transcription factor PAP1 Ecl1 PF12855.7 CDI74572.1 - 0.0049 18.0 28.8 0.091 13.9 14.7 2.2 2 0 0 2 2 2 2 ECL1/2/3 zinc binding proteins Ribosomal_60s PF00428.19 CDI74572.1 - 0.07 13.7 11.8 0.056 14.0 9.7 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF4813 PF16072.5 CDI74572.1 - 0.14 11.8 10.2 0.22 11.2 10.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Kinesin_assoc PF16183.5 CDI74572.1 - 0.19 11.9 20.0 0.025 14.7 4.5 2.5 1 1 1 2 2 2 0 Kinesin-associated PIG-S PF10510.9 CDI74572.1 - 0.41 9.4 21.2 0.65 8.8 0.5 2.2 2 0 0 2 2 2 0 Phosphatidylinositol-glycan biosynthesis class S protein DUF4692 PF15763.5 CDI74572.1 - 1.6 9.2 31.4 3.6 8.0 5.0 2.4 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) DUF4050 PF13259.6 CDI74572.1 - 2.6 8.3 28.7 3.2 8.0 19.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) Presenilin PF01080.17 CDI74573.1 - 0.12 11.1 46.1 0.13 11.0 46.1 1.0 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI74573.1 - 4.8 6.1 41.5 5.3 5.9 41.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Hydrolase_3 PF08282.12 CDI74576.1 - 1e-42 146.7 0.0 2.2e-23 83.3 0.0 2.0 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDI74576.1 - 8.1e-13 48.5 0.0 3.3e-07 30.1 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CDI74576.1 - 2.3e-05 24.8 0.1 0.08 13.2 0.0 2.9 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 CDI74576.1 - 0.0003 20.0 0.0 0.00053 19.2 0.0 1.4 1 1 0 1 1 1 1 Trehalose-phosphatase HAD PF12710.7 CDI74576.1 - 0.002 18.6 0.1 1.7 9.0 0.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDI74576.1 - 0.15 12.2 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase TFIIA PF03153.13 CDI74577.1 - 0.0017 18.5 31.2 0.0021 18.2 31.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI74577.1 - 0.0045 15.6 28.0 0.0061 15.2 28.0 1.2 1 0 0 1 1 1 1 Macoilin family PI3K_1B_p101 PF10486.9 CDI74577.1 - 0.0097 13.8 18.8 0.011 13.5 18.8 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit MAP65_ASE1 PF03999.12 CDI74577.1 - 0.034 12.9 23.3 0.04 12.6 23.3 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) BAF1_ABF1 PF04684.13 CDI74577.1 - 0.066 12.3 25.0 0.081 12.0 25.0 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor PNISR PF15996.5 CDI74577.1 - 0.17 12.1 24.6 0.23 11.7 24.6 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Miga PF10265.9 CDI74577.1 - 0.18 10.7 22.3 0.21 10.5 22.3 1.0 1 0 0 1 1 1 0 Mitoguardin SRP-alpha_N PF04086.13 CDI74577.1 - 0.19 11.6 22.8 0.23 11.3 22.8 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SURF6 PF04935.12 CDI74577.1 - 0.22 11.3 19.5 0.27 11.0 19.5 1.1 1 0 0 1 1 1 0 Surfeit locus protein 6 SLC12 PF03522.15 CDI74577.1 - 0.34 9.9 21.4 0.37 9.8 21.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Peptidase_S64 PF08192.11 CDI74577.1 - 0.43 9.0 25.6 0.47 8.9 25.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 CCDC24 PF15669.5 CDI74577.1 - 0.44 10.4 15.8 0.62 9.9 15.8 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Ndc1_Nup PF09531.10 CDI74577.1 - 0.57 8.8 25.2 0.65 8.6 25.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF1387 PF07139.11 CDI74577.1 - 0.65 9.7 22.3 0.79 9.4 22.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) SPX PF03105.19 CDI74577.1 - 0.89 9.4 24.1 1 9.2 24.1 1.0 1 0 0 1 1 1 0 SPX domain Lin-8 PF03353.15 CDI74577.1 - 1.2 8.7 25.3 1.4 8.4 25.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Apt1 PF10351.9 CDI74577.1 - 1.5 7.6 24.0 1.7 7.4 24.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain RAP1 PF07218.11 CDI74577.1 - 1.7 6.9 17.8 1.9 6.7 17.8 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CDC27 PF09507.10 CDI74577.1 - 2.2 7.6 27.0 2.7 7.3 27.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PAT1 PF09770.9 CDI74577.1 - 2.3 6.4 23.1 2.3 6.4 23.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF966 PF06136.13 CDI74577.1 - 2.4 7.8 23.6 3.6 7.2 23.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) ALMT PF11744.8 CDI74577.1 - 2.4 6.9 18.3 3 6.5 18.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 CDI74577.1 - 2.4 6.8 25.3 3.6 6.3 25.3 1.3 1 0 0 1 1 1 0 Presenilin DUF2681 PF10883.8 CDI74577.1 - 2.8 8.4 20.9 1.5 9.3 15.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) NST1 PF13945.6 CDI74577.1 - 3.1 7.9 30.9 3.9 7.5 30.9 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator SOG2 PF10428.9 CDI74577.1 - 3.7 6.6 27.6 4.2 6.4 27.6 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Peroxin-3 PF04882.12 CDI74577.1 - 5.2 6.0 26.9 6.5 5.6 26.9 1.1 1 0 0 1 1 1 0 Peroxin-3 GREB1 PF15782.5 CDI74577.1 - 5.3 4.0 24.2 6.1 3.8 24.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Cwf_Cwc_15 PF04889.12 CDI74577.1 - 6.1 6.5 23.4 11 5.7 23.4 1.4 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TMEM51 PF15345.6 CDI74577.1 - 8.3 6.2 21.6 13 5.6 21.6 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 Mem_trans PF03547.18 CDI74577.1 - 9.9 4.4 12.2 13 4.1 12.2 1.3 1 0 0 1 1 1 0 Membrane transport protein EIF4E-T PF10477.9 CDI74578.1 - 0.00011 21.2 24.2 0.00015 20.8 24.2 1.2 1 0 0 1 1 1 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E U1snRNP70_N PF12220.8 CDI74578.1 - 0.16 12.7 11.6 1.2 9.8 2.8 2.4 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4330 PF14221.6 CDI74578.1 - 0.56 10.4 2.2 13 6.0 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4330) Trp_oprn_chp PF09534.10 CDI74578.1 - 2.4 7.9 27.7 8.8 6.1 24.6 2.2 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Nse4_C PF08743.10 CDI74578.1 - 3.3 8.0 10.4 2.3 8.5 0.8 2.6 2 0 0 2 2 2 0 Nse4 C-terminal ARF7EP_C PF14949.6 CDI74578.1 - 4.1 8.0 12.9 7.8 7.2 5.9 2.4 2 0 0 2 2 2 0 ARF7 effector protein C-terminus DUF2785 PF10978.8 CDI74578.1 - 4.3 7.1 10.8 1.1 9.0 3.8 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2785) GPHR_N PF12537.8 CDI74578.1 - 4.8 7.3 6.8 1 9.5 0.1 2.8 2 1 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal DUF4307 PF14155.6 CDI74578.1 - 5.9 6.8 9.8 0.42 10.5 3.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) Pkinase PF00069.25 CDI74581.1 - 1.8e-29 102.9 0.4 2.4e-22 79.6 0.2 5.1 4 1 1 5 5 5 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI74581.1 - 7.9e-17 61.4 1.0 7.9e-17 61.4 1.0 3.7 2 1 2 4 4 4 2 Protein tyrosine kinase Dapper PF15268.6 CDI74581.1 - 2e-07 30.3 9.3 2e-07 30.3 9.3 2.5 2 1 0 2 2 2 1 Dapper Pkinase_fungal PF17667.1 CDI74581.1 - 4.4e-05 22.4 5.7 4.4e-05 22.4 5.7 3.1 1 1 1 3 3 3 1 Fungal protein kinase SR-25 PF10500.9 CDI74581.1 - 0.0024 17.5 5.3 0.0024 17.5 5.3 4.3 4 0 0 4 4 4 1 Nuclear RNA-splicing-associated protein SAPS PF04499.15 CDI74581.1 - 0.58 8.9 35.6 0.32 9.7 19.8 2.4 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein SLC12 PF03522.15 CDI74581.1 - 0.76 8.7 57.7 1.9 7.4 14.3 2.3 2 0 0 2 2 2 0 Solute carrier family 12 Exonuc_VII_L PF02601.15 CDI74581.1 - 1.5 8.3 65.0 0.6 9.6 16.5 2.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit RR_TM4-6 PF06459.12 CDI74581.1 - 2 8.2 57.2 0.25 11.1 28.9 3.2 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.10 CDI74582.1 - 0.61 10.4 20.8 0.76 10.1 20.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 V_ATPase_I PF01496.19 CDI74582.1 - 0.92 7.3 21.8 1.1 7.1 21.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3866 PF12982.7 CDI74582.1 - 1.4 7.9 8.2 1.6 7.8 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3866) 2OG-FeII_Oxy_5 PF13759.6 CDI74582.1 - 2.6 8.5 10.0 5.1 7.6 10.0 1.6 1 1 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase FapA PF03961.13 CDI74582.1 - 2.8 6.4 24.2 3.3 6.2 24.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Peptidase_S64 PF08192.11 CDI74582.1 - 3 6.2 22.0 3.7 5.9 22.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF4228 PF14009.6 CDI74582.1 - 3.2 8.1 9.9 3.8 7.9 9.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) ORC_WH_C PF18137.1 CDI74582.1 - 3.9 7.5 15.2 5.5 7.1 15.2 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Neur_chan_memb PF02932.16 CDI74582.1 - 4.1 7.4 16.9 5.2 7.1 16.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 CDI74582.1 - 4.7 5.2 20.5 5.4 5.0 20.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Connexin PF00029.19 CDI74582.1 - 5 6.8 14.0 7.2 6.3 14.0 1.3 1 0 0 1 1 1 0 Connexin Phage_GPO PF05929.11 CDI74582.1 - 5.1 6.6 23.4 6.6 6.3 23.4 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase AAA_11 PF13086.6 CDI74582.1 - 5.1 6.8 25.1 6 6.6 25.1 1.0 1 0 0 1 1 1 0 AAA domain Golgin_A5 PF09787.9 CDI74582.1 - 5.6 6.3 40.0 7.2 6.0 40.0 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 GSCFA PF08885.11 CDI74582.1 - 5.8 6.5 12.1 7.1 6.2 12.1 1.1 1 0 0 1 1 1 0 GSCFA family SLC12 PF03522.15 CDI74582.1 - 5.9 5.8 21.4 6.5 5.7 21.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 GNAT_acetyltr_2 PF13718.6 CDI74582.1 - 7.5 5.9 17.9 9.5 5.5 17.9 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Endostatin PF06482.11 CDI74582.1 - 7.7 5.9 20.8 8.3 5.8 20.8 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin 5_nucleotid PF05761.14 CDI74582.1 - 7.7 5.3 18.2 8.8 5.1 18.2 1.1 1 0 0 1 1 1 0 5' nucleotidase family O-antigen_lig PF13425.6 CDI74582.1 - 8 5.1 12.7 9.6 4.9 12.7 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF740 PF05340.12 CDI74582.1 - 8.9 4.9 10.9 11 4.7 10.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF740) DDHD PF02862.17 CDI74582.1 - 9.2 6.4 17.2 11 6.1 17.2 1.1 1 0 0 1 1 1 0 DDHD domain AIP3 PF03915.13 CDI74582.1 - 9.9 5.1 29.7 11 4.9 29.7 1.0 1 0 0 1 1 1 0 Actin interacting protein 3 DUF2722 PF10846.8 CDI74583.1 - 0.0014 17.7 5.6 0.0014 17.7 5.6 11.4 7 2 1 9 9 9 3 Protein of unknown function (DUF2722) Thioredoxin PF00085.20 CDI74584.1 - 2.1e-55 185.1 0.5 1.5e-31 108.4 0.3 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_3 PF13192.6 CDI74584.1 - 4.7e-09 36.2 0.0 0.0033 17.4 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin domain OST3_OST6 PF04756.13 CDI74584.1 - 6.1e-07 29.1 3.6 0.0004 19.8 0.0 2.9 3 0 0 3 3 2 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 CDI74584.1 - 6.2e-07 29.5 0.1 0.071 13.3 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_6 PF13848.6 CDI74584.1 - 1.2e-06 28.5 0.0 0.019 14.9 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CDI74584.1 - 1.9e-06 28.1 0.0 0.5 10.7 0.0 4.0 2 2 1 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 CDI74584.1 - 3.6e-05 23.7 0.2 0.055 13.4 0.0 2.7 2 0 0 2 2 2 2 AhpC/TSA family BUD22 PF09073.10 CDI74584.1 - 0.00069 19.1 0.9 0.00069 19.1 0.9 3.2 2 1 1 3 3 2 1 BUD22 Thioredoxin_2 PF13098.6 CDI74584.1 - 0.00095 19.6 7.2 1.8 9.1 0.3 4.4 3 2 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_9 PF14595.6 CDI74584.1 - 0.0091 15.8 10.4 0.41 10.4 0.0 3.5 4 0 0 4 4 3 2 Thioredoxin HyaE PF07449.11 CDI74584.1 - 0.048 13.6 0.0 3.6 7.6 0.0 2.5 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE TFIIA PF03153.13 CDI74584.1 - 0.051 13.6 50.3 0.22 11.5 50.4 1.8 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1840 PF08895.11 CDI74584.1 - 0.13 12.6 10.4 0.27 11.6 0.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Peptidase_S49_N PF08496.10 CDI74584.1 - 0.74 9.9 7.7 2.7 8.0 1.0 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal FKBP_N PF01346.18 CDI74584.1 - 1 10.3 13.7 7.6 7.6 1.3 2.6 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Med3 PF11593.8 CDI74584.1 - 6.6 5.8 42.4 17 4.5 42.4 1.6 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF853 PF05872.12 CDI74584.1 - 9.7 4.6 11.0 5.7 5.4 0.5 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) RskA PF10099.9 CDI74585.1 - 0.00036 20.9 10.3 0.00036 20.9 10.3 3.3 2 1 1 3 3 3 1 Anti-sigma-K factor rskA GNAT_acetyltr_2 PF13718.6 CDI74585.1 - 0.0014 18.1 1.7 0.0014 18.1 1.7 3.6 1 1 2 3 3 3 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 CDI74585.1 - 0.12 12.1 0.0 0.12 12.1 0.0 5.0 2 1 3 5 5 5 0 Possible tRNA binding domain Pex2_Pex12 PF04757.14 CDI74586.1 - 1.5e-05 24.7 0.1 1.5e-05 24.7 0.1 2.0 2 0 0 2 2 2 1 Pex2 / Pex12 amino terminal region Suf PF05843.14 CDI74586.1 - 0.0016 18.5 5.9 0.0016 18.5 5.9 2.5 2 1 0 2 2 1 1 Suppressor of forked protein (Suf) Pex14_N PF04695.13 CDI74586.1 - 0.0026 18.5 16.5 0.0026 18.5 16.5 3.6 3 1 1 4 4 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 CDI74586.1 - 0.0036 17.0 23.5 0.0036 17.0 23.5 2.7 2 1 0 2 2 1 1 Spt20 family Apt1 PF10351.9 CDI74586.1 - 0.01 14.7 8.5 1.4 7.7 8.5 2.1 1 1 0 1 1 1 0 Golgi-body localisation protein domain Connexin PF00029.19 CDI74586.1 - 0.012 15.4 2.9 0.021 14.6 2.9 1.3 1 0 0 1 1 1 0 Connexin EPL1 PF10513.9 CDI74586.1 - 0.014 15.8 1.4 0.014 15.8 1.4 2.8 2 1 0 2 2 1 0 Enhancer of polycomb-like SR-25 PF10500.9 CDI74586.1 - 0.034 13.8 33.1 0.74 9.4 4.5 3.3 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein SpoIIP PF07454.11 CDI74586.1 - 0.093 12.2 6.0 0.18 11.3 6.0 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF572 PF04502.13 CDI74586.1 - 0.11 12.1 8.6 0.15 11.6 2.9 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) RR_TM4-6 PF06459.12 CDI74586.1 - 0.13 12.1 11.1 0.025 14.4 7.5 1.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 SAPS PF04499.15 CDI74586.1 - 0.17 10.6 5.6 0.2 10.4 3.1 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF966 PF06136.13 CDI74586.1 - 0.26 11.0 14.2 0.43 10.2 3.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF966) DUF508 PF04370.12 CDI74586.1 - 0.26 11.0 11.5 3 7.6 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF508) Roughex PF06020.11 CDI74586.1 - 0.59 9.2 13.1 1.1 8.3 13.1 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Serinc PF03348.15 CDI74586.1 - 0.73 8.7 3.5 1.5 7.6 3.5 1.5 1 0 0 1 1 1 0 Serine incorporator (Serinc) AAA_23 PF13476.6 CDI74586.1 - 0.79 10.2 8.8 1.6 9.1 8.8 1.5 1 0 0 1 1 1 0 AAA domain FancD2 PF14631.6 CDI74586.1 - 0.83 7.0 5.2 1.2 6.4 5.2 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease CDC45 PF02724.14 CDI74586.1 - 1.1 7.5 12.1 0.065 11.5 4.8 2.0 2 0 0 2 2 2 0 CDC45-like protein SH2_2 PF14633.6 CDI74586.1 - 1.9 7.8 8.1 3.3 7.1 8.1 1.3 1 0 0 1 1 1 0 SH2 domain REC114-like PF15165.6 CDI74586.1 - 2.1 8.0 17.7 0.12 12.1 9.6 2.7 3 0 0 3 3 3 0 Meiotic recombination protein REC114-like DUF3408 PF11888.8 CDI74586.1 - 2.9 8.0 10.5 6.4 6.9 10.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) FTZ PF03867.14 CDI74586.1 - 3.1 7.3 18.1 1.1 8.7 7.5 2.6 2 0 0 2 2 2 0 Fushi tarazu (FTZ), N-terminal region UPF0565 PF10561.9 CDI74586.1 - 3.5 6.8 6.3 4.5 6.4 0.3 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 eIF-3_zeta PF05091.12 CDI74586.1 - 3.5 6.5 15.5 5.4 5.9 15.5 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Neur_chan_memb PF02932.16 CDI74586.1 - 4.8 7.2 12.3 0.13 12.3 2.0 2.5 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Sec62 PF03839.16 CDI74586.1 - 8.6 5.8 6.8 17 4.9 6.8 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Tim54 PF11711.8 CDI74586.1 - 9.2 4.9 11.2 17 4.0 11.2 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SR-25 PF10500.9 CDI74587.1 - 0.00015 21.5 7.4 0.00015 21.5 7.4 9.5 7 2 1 8 8 8 3 Nuclear RNA-splicing-associated protein GMC_oxred_C PF05199.13 CDI74588.1 - 2.4e-20 73.5 0.0 2.1e-15 57.5 0.0 2.4 2 0 0 2 2 2 2 GMC oxidoreductase GMC_oxred_N PF00732.19 CDI74588.1 - 6.6e-08 32.3 0.4 9.7e-07 28.4 0.1 2.2 2 0 0 2 2 2 1 GMC oxidoreductase SIR2 PF02146.17 CDI74590.1 - 2.8e-45 154.4 0.0 3.6e-45 154.0 0.0 1.1 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 CDI74590.1 - 3e-05 23.8 0.0 0.0019 18.0 0.0 2.2 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Med16 PF11635.8 CDI74590.1 - 0.24 9.3 0.0 0.29 9.0 0.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 16 Ras PF00071.22 CDI74591.1 - 8.5e-57 191.3 0.3 9.7e-57 191.1 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI74591.1 - 7.8e-33 113.3 0.0 1.4e-32 112.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI74591.1 - 5e-13 48.9 0.0 6.3e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDI74591.1 - 3.7e-08 33.5 0.0 5.6e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDI74591.1 - 6.2e-06 25.9 0.0 0.00029 20.5 0.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CDI74591.1 - 6.9e-06 25.6 0.1 9.4e-06 25.1 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CDI74591.1 - 0.001 18.5 0.0 0.0015 18.0 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 CDI74591.1 - 0.0067 16.4 0.1 0.12 12.2 0.1 2.4 1 1 2 3 3 3 1 RsgA GTPase Septin PF00735.18 CDI74591.1 - 0.011 15.1 0.1 0.019 14.3 0.1 1.4 1 0 0 1 1 1 0 Septin ATPase_2 PF01637.18 CDI74591.1 - 0.014 15.3 0.3 0.16 11.9 0.0 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TniB PF05621.11 CDI74591.1 - 0.017 14.5 0.0 0.025 14.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein FeoB_N PF02421.18 CDI74591.1 - 0.032 13.8 0.1 0.31 10.6 0.1 2.3 2 1 1 3 3 3 0 Ferrous iron transport protein B G-alpha PF00503.20 CDI74591.1 - 0.076 12.2 1.5 0.2 10.8 0.3 1.9 1 1 1 2 2 2 0 G-protein alpha subunit PduV-EutP PF10662.9 CDI74591.1 - 0.097 12.4 0.3 0.24 11.1 0.1 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 CDI74591.1 - 0.18 12.2 0.0 0.22 11.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain MPS2 PF17060.5 CDI74592.1 - 6.2 6.0 13.2 9.8 5.3 5.7 2.4 2 0 0 2 2 2 0 Monopolar spindle protein 2 DUF2722 PF10846.8 CDI74594.1 - 0.00023 20.3 4.6 0.00023 20.3 4.6 6.0 5 1 1 6 6 6 3 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI74594.1 - 0.0029 17.2 98.0 0.061 12.9 2.9 5.5 6 0 0 6 6 6 5 Spt20 family PQQ PF01011.21 CDI74594.1 - 0.0034 17.2 0.2 2.4 8.2 0.1 3.6 4 0 0 4 4 4 1 PQQ enzyme repeat EOS1 PF12326.8 CDI74594.1 - 0.035 14.1 0.2 0.035 14.1 0.2 4.4 3 2 1 4 4 4 0 N-glycosylation protein PDDEXK_6 PF04720.12 CDI74595.1 - 2.6 7.9 7.2 3.8 7.4 7.2 1.4 1 1 0 1 1 1 0 PDDEXK-like family of unknown function Lin-8 PF03353.15 CDI74595.1 - 3.5 7.1 5.0 2.2 7.8 4.0 1.3 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF755 PF05501.11 CDI74595.1 - 4.5 7.6 18.9 0.36 11.1 9.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF755) DUF3159 PF11361.8 CDI74595.1 - 7.4 6.3 10.4 2.5 7.8 7.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3159) Apt1 PF10351.9 CDI74595.1 - 8.1 5.2 8.5 8.5 5.1 8.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain TAF4 PF05236.14 CDI74595.1 - 8.2 6.1 24.9 1.3 8.7 13.3 2.1 1 1 1 2 2 2 0 Transcription initiation factor TFIID component TAF4 family RskA PF10099.9 CDI74595.1 - 8.9 6.6 33.3 4.5 7.5 6.6 2.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI74596.1 - 0.0071 16.4 23.8 0.0088 16.1 23.8 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Med8 PF10232.9 CDI74596.1 - 0.065 12.8 12.3 0.092 12.3 12.3 1.2 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 Mit_KHE1 PF10173.9 CDI74596.1 - 0.21 11.7 3.2 0.29 11.2 3.2 1.2 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related DDHD PF02862.17 CDI74596.1 - 0.52 10.4 6.8 0.7 10.0 6.8 1.3 1 0 0 1 1 1 0 DDHD domain FAM60A PF15396.6 CDI74596.1 - 0.64 10.0 4.4 0.79 9.7 4.4 1.3 1 0 0 1 1 1 0 Protein Family FAM60A SLC12 PF03522.15 CDI74596.1 - 1.4 7.9 11.3 1.6 7.7 11.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI74596.1 - 1.5 8.8 5.2 1.8 8.6 5.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.10 CDI74596.1 - 2 7.0 5.9 2.3 6.8 5.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Dicty_REP PF05086.12 CDI74596.1 - 2.2 6.2 7.0 2.5 5.9 7.0 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Aminopep PF10023.9 CDI74596.1 - 2.9 7.1 15.6 5 6.4 15.6 1.3 1 0 0 1 1 1 0 Putative aminopeptidase Presenilin PF01080.17 CDI74596.1 - 3 6.5 15.0 3.5 6.3 15.0 1.1 1 0 0 1 1 1 0 Presenilin TERB2 PF15101.6 CDI74596.1 - 3.1 7.8 14.7 4.6 7.2 14.7 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Lin-8 PF03353.15 CDI74596.1 - 5.3 6.5 21.3 6.3 6.3 21.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MDM10 PF12519.8 CDI74596.1 - 6.6 5.5 10.4 9.1 5.0 10.4 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 V_ATPase_I PF01496.19 CDI74596.1 - 7.2 4.4 11.2 7.2 4.4 11.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Hydin_ADK PF17213.3 CDI74596.1 - 7.7 6.7 11.4 12 6.2 11.4 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Band_3_cyto PF07565.13 CDI74596.1 - 8.6 6.1 12.1 12 5.6 12.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Spt20 PF12090.8 CDI74597.1 - 0.011 15.4 27.0 0.011 15.4 27.0 1.1 1 0 0 1 1 1 0 Spt20 family Pex14_N PF04695.13 CDI74597.1 - 0.029 15.0 19.2 0.031 14.9 19.2 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Med15 PF09606.10 CDI74597.1 - 0.16 10.6 22.8 0.17 10.5 22.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4820 PF16091.5 CDI74597.1 - 0.39 10.0 8.9 0.53 9.6 8.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TFIIA PF03153.13 CDI74597.1 - 0.41 10.6 29.4 0.42 10.6 29.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4770 PF15994.5 CDI74597.1 - 0.57 10.4 10.7 0.61 10.3 10.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) PEHE PF15275.6 CDI74597.1 - 0.6 10.7 9.2 0.62 10.7 9.2 1.1 1 0 0 1 1 1 0 PEHE domain EPL1 PF10513.9 CDI74597.1 - 0.66 10.4 9.7 0.69 10.3 9.7 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like OATP PF03137.20 CDI74597.1 - 0.93 7.7 4.3 0.97 7.6 4.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Connexin PF00029.19 CDI74597.1 - 1.3 8.7 4.8 1.2 8.8 4.8 1.1 1 0 0 1 1 1 0 Connexin eIF-3_zeta PF05091.12 CDI74597.1 - 1.4 7.8 12.2 1.4 7.8 12.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) WBP-1 PF11669.8 CDI74597.1 - 1.6 9.4 6.0 1.9 9.2 6.0 1.2 1 0 0 1 1 1 0 WW domain-binding protein 1 UPF0560 PF10577.9 CDI74597.1 - 2.7 6.4 13.8 2.5 6.5 13.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Band_3_cyto PF07565.13 CDI74597.1 - 3.2 7.5 8.4 3.1 7.5 8.4 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain XRN_N PF03159.18 CDI74597.1 - 3.3 7.1 10.3 3.2 7.1 10.3 1.1 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus FTZ PF03867.14 CDI74597.1 - 5.9 6.3 20.1 8.9 5.8 20.1 1.3 1 1 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region SLC12 PF03522.15 CDI74597.1 - 5.9 5.8 10.3 5.8 5.8 10.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 RNA_pol_Rbc25 PF08292.12 CDI74597.1 - 6.1 7.1 10.5 1.9 8.7 8.0 1.4 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 Presenilin PF01080.17 CDI74597.1 - 7.9 5.1 14.1 8.1 5.1 14.1 1.0 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI74597.1 - 8.9 6.3 9.3 9.2 6.2 9.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CLN3 PF02487.17 CDI74597.1 - 9.3 5.2 7.4 8.5 5.3 7.4 1.1 1 0 0 1 1 1 0 CLN3 protein ALMT PF11744.8 CDI74597.1 - 9.8 4.9 8.9 9.9 4.9 8.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Utp14 PF04615.13 CDI74598.1 - 0.051 12.1 40.8 0.062 11.9 40.8 1.0 1 0 0 1 1 1 0 Utp14 protein RskA PF10099.9 CDI74598.1 - 0.7 10.2 51.8 0.13 12.5 3.2 3.5 1 1 2 3 3 3 0 Anti-sigma-K factor rskA Helicase_C PF00271.31 CDI74599.1 - 9.5e-19 67.8 0.0 9.5e-19 67.8 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDI74599.1 - 1e-10 41.6 16.6 2.1e-08 34.1 16.6 2.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.6 CDI74599.1 - 1.6e-07 31.4 0.1 3.7e-07 30.3 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) TAF4 PF05236.14 CDI74599.1 - 0.00035 20.4 1.3 0.00035 20.4 1.3 6.0 2 2 2 5 5 5 1 Transcription initiation factor TFIID component TAF4 family CobT PF06213.12 CDI74599.1 - 0.0044 16.5 12.5 0.0044 16.5 12.5 7.2 6 1 0 6 6 6 2 Cobalamin biosynthesis protein CobT SseC PF04888.12 CDI74599.1 - 0.006 16.2 15.3 0.006 16.2 15.3 5.9 4 2 1 6 6 6 1 Secretion system effector C (SseC) like family BUD22 PF09073.10 CDI74600.1 - 0.067 12.5 40.7 0.079 12.3 40.7 1.2 1 0 0 1 1 1 0 BUD22 Nha1_C PF08619.10 CDI74600.1 - 0.22 10.7 32.0 0.28 10.3 32.0 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus V_ATPase_I PF01496.19 CDI74600.1 - 1.4 6.7 19.0 1.9 6.3 19.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Gti1_Pac2 PF09729.9 CDI74600.1 - 1.4 8.9 21.3 2 8.5 21.3 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family Zip PF02535.22 CDI74600.1 - 1.6 7.8 17.4 1.8 7.7 17.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 CDI74600.1 - 3.8 6.2 28.6 4 6.1 28.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PCM1_C PF15717.5 CDI74600.1 - 4.2 5.9 27.1 5.1 5.7 27.1 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus DUF5427 PF10310.9 CDI74600.1 - 6 5.7 26.1 6.7 5.5 26.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Spore_coat_CotO PF14153.6 CDI74600.1 - 7.1 6.5 35.9 8.1 6.3 35.9 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Nop14 PF04147.12 CDI74600.1 - 7.8 4.6 40.8 9.6 4.3 40.8 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 CDI74600.1 - 8.1 5.1 24.8 8.5 5.0 24.8 1.1 1 0 0 1 1 1 0 Presenilin XPC-binding PF09280.11 CDI74602.1 - 7.6e-14 51.2 10.7 7.6e-14 51.2 10.7 3.5 2 1 1 3 3 3 1 XPC-binding domain Hamartin PF04388.12 CDI74602.1 - 0.017 13.8 41.1 0.025 13.3 41.1 1.3 1 0 0 1 1 1 0 Hamartin protein DUF2722 PF10846.8 CDI74602.1 - 0.11 11.4 81.6 0.01 14.8 11.7 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2722) DUF4834 PF16118.5 CDI74602.1 - 9.6 7.2 54.5 3.5 8.6 5.9 4.6 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) SR-25 PF10500.9 CDI74603.1 - 9.7e-06 25.4 16.2 9.7e-06 25.4 16.2 3.2 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI74603.1 - 0.0022 17.7 34.1 0.0022 17.7 34.1 2.4 2 0 0 2 2 2 1 Spt20 family YL1 PF05764.13 CDI74603.1 - 0.022 14.9 28.8 0.038 14.1 28.8 1.3 1 0 0 1 1 1 0 YL1 nuclear protein SAPS PF04499.15 CDI74603.1 - 0.32 9.7 17.8 0.056 12.2 4.3 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein EOS1 PF12326.8 CDI74603.1 - 0.37 10.7 16.9 0.045 13.7 1.1 2.2 2 0 0 2 2 2 0 N-glycosylation protein ASD2 PF08687.11 CDI74603.1 - 0.67 9.5 29.4 0.89 9.1 9.4 2.3 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 MCU PF04678.13 CDI74603.1 - 1.8 8.6 15.0 0.3 11.2 1.4 2.3 2 0 0 2 2 2 0 Mitochondrial calcium uniporter RR_TM4-6 PF06459.12 CDI74603.1 - 1.9 8.3 27.8 2.7 7.8 12.5 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF3807 PF12720.7 CDI74603.1 - 2.8 8.2 38.4 0.56 10.5 16.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) PRP1_N PF06424.12 CDI74603.1 - 4.1 7.8 24.8 0.43 11.0 8.5 2.4 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal SID-1_RNA_chan PF13965.6 CDI74603.1 - 4.4 5.6 12.6 0.41 9.0 0.3 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Peptidase_S64 PF08192.11 CDI74603.1 - 9 4.6 30.8 15 3.9 30.8 1.3 1 0 0 1 1 1 0 Peptidase family S64 Pro_isomerase PF00160.21 CDI74604.1 - 6.2e-18 65.6 0.0 7e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD AsnA PF03590.15 CDI74605.1 - 1.1e-85 287.1 0.0 1.3e-85 286.8 0.0 1.0 1 0 0 1 1 1 1 Aspartate-ammonia ligase Clathrin PF00637.20 CDI74606.1 - 6.7e-06 26.0 0.2 3.4e-05 23.7 0.1 2.3 3 0 0 3 3 3 1 Region in Clathrin and VPS VPS11_C PF12451.8 CDI74606.1 - 9.2e-06 25.8 0.1 2.3e-05 24.5 0.1 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 CDI74606.1 - 0.0036 17.3 4.2 0.01 15.9 4.2 1.8 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 CDI74606.1 - 0.0054 16.5 1.1 0.0054 16.5 1.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 CDI74606.1 - 0.01 15.7 2.3 0.035 14.0 2.3 2.0 1 0 0 1 1 1 0 PHD-finger Vps39_2 PF10367.9 CDI74606.1 - 0.01 16.3 0.2 0.03 14.8 0.2 1.7 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.6 CDI74606.1 - 0.082 12.9 7.4 0.25 11.3 7.4 1.9 1 0 0 1 1 1 0 zinc-RING finger domain Bacillus_HBL PF05791.11 CDI74606.1 - 0.082 12.7 0.3 0.16 11.8 0.3 1.4 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) zf-C3HC4 PF00097.25 CDI74606.1 - 0.083 12.8 5.3 0.29 11.0 5.4 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-TFIIIC PF12660.7 CDI74606.1 - 0.11 12.5 2.9 0.64 10.0 1.3 2.5 2 0 0 2 2 2 0 Putative zinc-finger of transcription factor IIIC complex zf-rbx1 PF12678.7 CDI74606.1 - 0.83 10.0 10.5 0.19 12.1 0.5 3.4 3 0 0 3 3 3 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CDI74606.1 - 1.8 8.9 9.0 15 6.0 9.2 2.4 1 1 1 2 2 2 0 Ring finger domain zf-RING_UBOX PF13445.6 CDI74606.1 - 5.9 7.0 7.2 1.2 9.3 3.1 1.9 2 0 0 2 2 2 0 RING-type zinc-finger IMCp PF12314.8 CDI74607.1 - 2.5e-25 88.6 53.9 4.2e-25 87.9 19.2 3.8 2 1 2 4 4 4 3 Inner membrane complex protein ubiquitin PF00240.23 CDI74608.1 - 3.3e-12 46.0 0.1 3.9e-07 29.7 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 CDI74608.1 - 0.00037 20.3 0.7 0.00092 19.0 0.3 1.8 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 CDI74608.1 - 0.0011 19.6 0.1 0.0029 18.2 0.0 1.7 2 0 0 2 2 2 1 WXG100 protein secretion system (Wss), protein YukD Ubiquitin_4 PF18036.1 CDI74608.1 - 0.0013 18.8 0.1 1.4 9.1 0.1 3.4 2 1 0 2 2 2 1 Ubiquitin-like domain UN_NPL4 PF11543.8 CDI74608.1 - 0.0049 17.3 0.0 0.017 15.6 0.0 1.9 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 ANAPC15 PF15243.6 CDI74609.1 - 0.051 14.0 10.0 0.12 12.8 10.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Mog1 PF04603.12 CDI74610.1 - 7.9e-29 100.8 0.0 1e-28 100.4 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein Notch PF00066.17 CDI74612.1 - 2.9e-38 130.0 119.7 3.1e-08 33.9 13.5 6.7 7 0 0 7 7 7 6 LNR domain DUF4949 PF16307.5 CDI74612.1 - 0.067 13.3 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4949) Fasciclin PF02469.22 CDI74614.1 - 1.1e-06 28.9 0.0 3.1e-06 27.4 0.0 1.7 1 1 0 1 1 1 1 Fasciclin domain Myb_DNA-binding PF00249.31 CDI74615.1 - 1.2e-10 41.4 1.0 3.7e-10 39.8 0.5 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDI74615.1 - 1.6e-06 28.3 0.8 6.3e-06 26.3 0.8 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain EF-hand_7 PF13499.6 CDI74618.1 - 2.8e-13 50.1 0.1 9.7e-12 45.2 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 CDI74618.1 - 4.2e-13 47.8 0.3 6.5e-06 25.3 0.1 3.5 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 CDI74618.1 - 6.4e-11 41.3 0.6 7.7e-06 25.4 0.2 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 CDI74618.1 - 1.8e-08 34.1 1.3 3.3e-05 23.6 0.0 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 CDI74618.1 - 2e-07 30.2 0.5 3e-05 23.3 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.11 CDI74618.1 - 3.9e-06 27.7 0.0 8.5e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 CDI74618.1 - 0.0022 18.3 0.0 0.0039 17.5 0.0 1.4 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 CDI74618.1 - 0.0054 17.0 0.1 0.01 16.2 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain DUF5580 PF17743.1 CDI74618.1 - 0.013 14.0 0.0 0.016 13.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) Myb_DNA-binding PF00249.31 CDI74619.1 - 0.0035 17.5 0.0 0.032 14.4 0.0 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain PikAIV_N PF18605.1 CDI74620.1 - 0.014 15.0 3.6 0.014 15.0 3.6 4.0 3 1 1 4 4 4 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Leu_zip PF15294.6 CDI74620.1 - 0.045 13.3 11.1 0.18 11.3 6.3 2.2 2 0 0 2 2 2 0 Leucine zipper GIT_CC PF16559.5 CDI74620.1 - 0.88 9.5 12.0 0.83 9.6 0.1 3.8 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF1018 PF06252.12 CDI74620.1 - 1.4 9.9 8.2 0.85 10.6 5.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1018) CCDC92 PF14916.6 CDI74620.1 - 1.9 8.3 6.9 1.7 8.5 0.2 3.1 3 0 0 3 3 3 0 Coiled-coil domain of unknown function CS PF04969.16 CDI74621.1 - 1.1e-14 55.2 0.0 2e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 CS domain Nudc_N PF14050.6 CDI74621.1 - 1.3e-11 44.3 0.4 2.6e-11 43.3 0.4 1.5 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. Plasmodium_Vir PF05795.11 CDI74621.1 - 1.1 8.6 6.1 0.2 11.0 2.1 1.6 2 0 0 2 2 2 0 Plasmodium vivax Vir protein WASH-7_C PF14746.6 CDI74621.1 - 7.4 6.2 10.5 0.27 10.9 4.2 1.7 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal Borrelia_P83 PF05262.11 CDI74622.1 - 1.2 7.6 5.3 1.4 7.3 5.3 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein HEAT PF02985.22 CDI74623.1 - 0.59 10.5 4.4 28 5.3 0.0 4.8 4 0 0 4 4 4 0 HEAT repeat Coatomer_WDAD PF04053.14 CDI74624.1 - 0.00014 21.1 0.8 0.0022 17.1 0.1 2.2 2 0 0 2 2 2 2 Coatomer WD associated region TPR_7 PF13176.6 CDI74624.1 - 0.0093 15.9 1.0 1.5 9.0 0.0 4.9 6 1 1 7 7 7 1 Tetratricopeptide repeat TPH PF13868.6 CDI74627.1 - 5.9e-10 38.2 147.5 5.9e-10 38.2 147.5 2.2 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain CLASP_N PF12348.8 CDI74628.1 - 0.00048 19.8 0.6 6 6.4 0.0 4.3 3 1 1 4 4 4 2 CLASP N terminal ScsC_N PF18312.1 CDI74628.1 - 0.052 13.4 0.5 0.44 10.4 1.2 2.2 2 0 0 2 2 2 0 Copper resistance protein ScsC N-terminal domain HEAT_EZ PF13513.6 CDI74628.1 - 0.053 14.0 21.4 6.2 7.4 0.2 6.4 5 0 0 5 5 5 0 HEAT-like repeat Cnd1 PF12717.7 CDI74628.1 - 0.17 11.9 8.8 0.051 13.6 0.4 4.1 4 2 2 6 6 6 0 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDI74628.1 - 2.6 8.5 22.2 0.54 10.7 4.3 5.4 5 1 0 5 5 5 0 HEAT repeats WD40 PF00400.32 CDI74629.1 - 4.8e-06 27.2 7.8 2 9.4 0.0 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI74629.1 - 0.069 13.5 0.0 1.4 9.2 0.0 3.0 2 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF2722 PF10846.8 CDI74630.1 - 0.0038 16.2 0.6 0.0038 16.2 0.6 7.0 4 2 2 6 6 6 1 Protein of unknown function (DUF2722) FAM176 PF14851.6 CDI74631.1 - 0.0019 17.9 3.7 0.002 17.8 3.7 1.1 1 0 0 1 1 1 1 FAM176 family CLN3 PF02487.17 CDI74631.1 - 0.0024 17.0 8.6 0.0026 16.9 8.6 1.0 1 0 0 1 1 1 1 CLN3 protein V_ATPase_I PF01496.19 CDI74631.1 - 0.003 15.6 13.6 0.0031 15.5 13.6 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family SpoIIP PF07454.11 CDI74631.1 - 0.0074 15.8 9.7 0.0074 15.8 9.7 1.0 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) TRAP_alpha PF03896.16 CDI74631.1 - 0.0081 15.4 5.7 0.0093 15.2 5.7 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit DUF4834 PF16118.5 CDI74631.1 - 0.012 16.5 15.6 0.018 16.0 15.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 CDI74631.1 - 0.013 14.3 10.0 0.013 14.3 10.0 1.2 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 CDI74631.1 - 0.013 15.3 6.8 0.014 15.2 6.8 1.1 1 0 0 1 1 1 0 Connexin EMC3_TMCO1 PF01956.16 CDI74631.1 - 0.014 15.1 14.0 0.015 15.0 14.0 1.0 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like SID-1_RNA_chan PF13965.6 CDI74631.1 - 0.022 13.2 2.8 0.021 13.2 2.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 FHIPEP PF00771.20 CDI74631.1 - 0.055 11.9 7.1 0.057 11.9 7.1 1.1 1 0 0 1 1 1 0 FHIPEP family Ctr PF04145.15 CDI74631.1 - 0.09 13.4 4.9 0.1 13.2 4.9 1.1 1 0 0 1 1 1 0 Ctr copper transporter family DDHD PF02862.17 CDI74631.1 - 0.094 12.9 8.2 0.093 12.9 8.2 1.1 1 0 0 1 1 1 0 DDHD domain CbiQ PF02361.16 CDI74631.1 - 0.098 12.3 0.9 0.097 12.3 0.9 1.1 1 0 0 1 1 1 0 Cobalt transport protein O-antigen_lig PF13425.6 CDI74631.1 - 0.17 10.7 2.9 0.18 10.6 2.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CSG2 PF16965.5 CDI74631.1 - 0.18 10.7 5.6 0.17 10.8 5.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4746 PF15928.5 CDI74631.1 - 0.18 11.2 7.3 0.18 11.2 7.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) OATP PF03137.20 CDI74631.1 - 0.2 9.9 5.6 0.21 9.9 5.6 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Folate_carrier PF01770.18 CDI74631.1 - 0.21 10.3 5.7 0.2 10.4 5.7 1.0 1 0 0 1 1 1 0 Reduced folate carrier Serinc PF03348.15 CDI74631.1 - 0.23 10.4 5.3 0.23 10.4 5.3 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4446 PF14584.6 CDI74631.1 - 0.26 11.2 6.3 0.27 11.2 6.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF2149 PF09919.9 CDI74631.1 - 0.27 11.5 8.4 0.31 11.3 8.4 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) Peroxin-13_N PF04088.13 CDI74631.1 - 0.28 11.5 6.3 0.31 11.3 6.3 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DcuA_DcuB PF03605.14 CDI74631.1 - 0.29 10.0 3.1 0.3 9.9 3.1 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter CobT PF06213.12 CDI74631.1 - 0.33 10.3 22.1 0.36 10.2 22.1 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT K_trans PF02705.16 CDI74631.1 - 0.41 9.1 1.7 0.44 9.0 1.7 1.0 1 0 0 1 1 1 0 K+ potassium transporter DUF2828 PF11443.8 CDI74631.1 - 0.42 8.6 12.2 0.44 8.6 12.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) GRP PF07172.11 CDI74631.1 - 0.43 11.3 5.4 0.69 10.6 5.4 1.4 1 1 0 1 1 1 0 Glycine rich protein family PIP5K PF01504.18 CDI74631.1 - 0.45 9.7 10.5 0.45 9.7 10.5 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Scs3p PF10261.9 CDI74631.1 - 0.46 10.0 6.3 0.5 9.8 6.3 1.0 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Dpy19 PF10034.9 CDI74631.1 - 0.76 7.9 5.5 0.88 7.7 5.5 1.2 1 0 0 1 1 1 0 Q-cell neuroblast polarisation Nucleoside_tran PF01733.18 CDI74631.1 - 0.79 9.0 3.8 0.84 9.0 3.8 1.0 1 0 0 1 1 1 0 Nucleoside transporter EOS1 PF12326.8 CDI74631.1 - 0.8 9.6 4.8 0.86 9.5 4.8 1.2 1 0 0 1 1 1 0 N-glycosylation protein Pet20 PF08692.10 CDI74631.1 - 0.9 10.3 6.3 1 10.1 6.3 1.1 1 0 0 1 1 1 0 Mitochondrial protein Pet20 Cytochrom_B_N_2 PF13631.6 CDI74631.1 - 1 9.3 5.7 2 8.4 5.7 1.6 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB DUF1180 PF06679.12 CDI74631.1 - 1.1 9.6 6.7 1.3 9.4 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) PigN PF04987.14 CDI74631.1 - 1.4 7.7 6.1 1.6 7.5 6.1 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) RBP_receptor PF14752.6 CDI74631.1 - 1.4 7.4 9.4 1.5 7.3 9.4 1.1 1 0 0 1 1 1 0 Retinol binding protein receptor ABC2_membrane_2 PF12679.7 CDI74631.1 - 1.4 8.1 7.2 1.6 7.9 7.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein FPN1 PF06963.12 CDI74631.1 - 1.6 7.2 4.2 1.6 7.2 4.2 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) PepSY_TM PF03929.16 CDI74631.1 - 1.8 8.2 6.7 1.8 8.1 6.7 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Neur_chan_memb PF02932.16 CDI74631.1 - 2.1 8.3 10.6 2.3 8.2 10.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region 7tm_1 PF00001.21 CDI74631.1 - 2.9 7.1 5.3 4 6.7 5.3 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF2126 PF09899.9 CDI74631.1 - 3.3 5.7 10.1 3.4 5.6 10.1 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CPSF100_C PF13299.6 CDI74631.1 - 3.4 7.8 12.5 3.7 7.7 12.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal NEMP PF10225.9 CDI74631.1 - 3.4 7.3 6.8 3.5 7.2 6.8 1.0 1 0 0 1 1 1 0 NEMP family Mem_trans PF03547.18 CDI74631.1 - 4.3 5.6 5.8 4.6 5.5 5.8 1.0 1 0 0 1 1 1 0 Membrane transport protein CNDH2_M PF16869.5 CDI74631.1 - 4.5 8.0 14.6 5.2 7.8 14.6 1.1 1 0 0 1 1 1 0 PF16858 Kei1 PF08552.11 CDI74631.1 - 4.6 7.1 8.8 4.9 7.0 8.8 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DEAD PF00270.29 CDI74632.1 - 5.6e-17 62.1 21.6 5.6e-17 62.1 21.6 3.4 2 1 0 2 2 1 1 DEAD/DEAH box helicase Endostatin PF06482.11 CDI74632.1 - 0.00034 20.2 26.9 0.0017 17.9 17.3 2.1 2 0 0 2 2 2 2 Collagenase NC10 and Endostatin Zip PF02535.22 CDI74632.1 - 0.00045 19.5 14.5 0.0011 18.3 4.2 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter SpoIIIAH PF12685.7 CDI74632.1 - 0.00057 19.8 26.8 0.0014 18.5 8.6 2.3 2 0 0 2 2 2 1 SpoIIIAH-like protein Sin_N PF04801.13 CDI74632.1 - 0.0029 16.9 32.0 0.0029 16.9 32.0 2.1 2 0 0 2 2 2 1 Sin-like protein conserved region RNA_pol_Rpc4 PF05132.14 CDI74632.1 - 0.0032 17.9 11.7 0.0032 17.9 11.7 2.5 2 0 0 2 2 2 1 RNA polymerase III RPC4 AAR2 PF05282.11 CDI74632.1 - 0.0061 16.0 14.7 0.04 13.3 5.5 2.2 2 0 0 2 2 2 2 AAR2 protein PTPRCAP PF15713.5 CDI74632.1 - 0.0076 16.5 38.6 0.17 12.1 21.8 2.3 2 0 0 2 2 2 2 Protein tyrosine phosphatase receptor type C-associated TCP PF03634.13 CDI74632.1 - 0.021 15.4 33.3 0.031 14.8 18.5 2.4 2 0 0 2 2 2 0 TCP family transcription factor CCDC53 PF10152.9 CDI74632.1 - 0.021 15.3 39.8 0.11 12.9 24.6 2.6 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex DUF4045 PF13254.6 CDI74632.1 - 0.046 13.4 29.4 0.041 13.5 15.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) SAGA-Tad1 PF12767.7 CDI74632.1 - 0.049 13.4 26.0 0.092 12.5 15.8 2.1 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit RR_TM4-6 PF06459.12 CDI74632.1 - 0.057 13.2 40.9 0.46 10.3 27.7 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI74632.1 - 0.067 12.2 34.9 0.039 13.0 21.3 2.1 2 0 0 2 2 2 0 Solute carrier family 12 CAF1 PF04857.20 CDI74632.1 - 0.074 12.2 16.3 0.06 12.5 9.7 2.1 2 0 0 2 2 2 0 CAF1 family ribonuclease Lin-8 PF03353.15 CDI74632.1 - 0.085 12.4 39.8 0.61 9.6 25.0 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Otopetrin PF03189.13 CDI74632.1 - 0.15 10.9 18.2 0.22 10.3 11.3 2.1 2 0 0 2 2 2 0 Otopetrin DUF913 PF06025.12 CDI74632.1 - 0.17 10.8 25.1 0.31 10.0 13.5 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 CDI74632.1 - 0.21 10.3 47.2 0.22 10.3 30.4 2.2 2 0 0 2 2 2 0 Presenilin Apt1 PF10351.9 CDI74632.1 - 0.23 10.3 24.5 0.058 12.3 9.6 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain DUF2052 PF09747.9 CDI74632.1 - 0.24 11.5 40.4 0.32 11.1 24.3 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SpoIIP PF07454.11 CDI74632.1 - 0.24 10.8 40.0 0.38 10.2 24.0 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) CCSAP PF15748.5 CDI74632.1 - 0.25 11.5 42.4 0.6 10.2 27.4 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Pannexin_like PF12534.8 CDI74632.1 - 0.43 9.6 27.2 0.41 9.7 14.6 2.1 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 CDC45 PF02724.14 CDI74632.1 - 0.43 8.8 40.3 0.051 11.9 5.4 2.1 2 0 0 2 2 2 0 CDC45-like protein SMYLE_N PF18615.1 CDI74632.1 - 0.59 9.6 25.3 0.18 11.3 12.3 2.4 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Pkinase_fungal PF17667.1 CDI74632.1 - 0.67 8.7 17.6 0.15 10.8 9.3 2.1 2 0 0 2 2 2 0 Fungal protein kinase DUF5427 PF10310.9 CDI74632.1 - 0.77 8.7 46.0 0.38 9.7 26.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5427) Dsh_C PF12316.8 CDI74632.1 - 0.99 9.8 21.8 2.3 8.6 1.8 2.2 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal DUF4569 PF15133.6 CDI74632.1 - 1 9.0 37.2 4.8 6.8 25.7 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4569) NARP1 PF12569.8 CDI74632.1 - 1.3 7.9 34.1 0.22 10.4 19.9 2.2 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 FAM60A PF15396.6 CDI74632.1 - 1.3 8.9 35.0 0.28 11.2 18.8 2.2 2 0 0 2 2 2 0 Protein Family FAM60A DUF1387 PF07139.11 CDI74632.1 - 1.5 8.5 36.4 2.9 7.5 23.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) AbLIM_anchor PF16182.5 CDI74632.1 - 1.5 8.6 22.4 2.1 8.1 2.4 2.1 2 0 0 2 2 2 0 Putative adherens-junction anchoring region of AbLIM Raftlin PF15250.6 CDI74632.1 - 1.6 7.4 29.2 0.52 9.0 15.9 2.1 2 0 0 2 2 2 0 Raftlin DUF2151 PF10221.9 CDI74632.1 - 1.6 7.2 21.7 0.71 8.4 11.6 2.1 2 0 0 2 2 2 0 Cell cycle and development regulator Neur_chan_memb PF02932.16 CDI74632.1 - 1.7 8.6 33.2 4.6 7.2 3.7 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region eIF-3_zeta PF05091.12 CDI74632.1 - 2.5 7.0 49.1 1.8 7.4 33.5 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CNDH2_C PF16858.5 CDI74632.1 - 2.7 7.8 36.3 0.69 9.7 20.6 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term MMR1 PF08505.10 CDI74632.1 - 3.4 7.9 46.5 2.4 8.4 29.8 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein SUFU_C PF12470.8 CDI74632.1 - 3.9 7.5 20.6 12 5.9 0.5 2.4 2 0 0 2 2 2 0 Suppressor of Fused Gli/Ci N terminal binding domain DUF4746 PF15928.5 CDI74632.1 - 3.9 6.8 29.5 0.88 8.9 16.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) SDA1 PF05285.12 CDI74632.1 - 4.3 6.7 39.4 1.2 8.5 11.2 2.1 2 0 0 2 2 2 0 SDA1 MMU163 PF17119.5 CDI74632.1 - 5.1 6.2 22.0 2.7 7.1 9.9 2.4 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis Tim54 PF11711.8 CDI74632.1 - 5.2 5.7 35.6 3.4 6.4 5.3 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 SOBP PF15279.6 CDI74632.1 - 5.7 7.5 31.8 4.2 7.9 21.7 2.1 2 0 0 2 2 2 0 Sine oculis-binding protein PIP5K PF01504.18 CDI74632.1 - 5.9 6.0 31.6 0.21 10.8 15.4 2.3 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF4776 PF16003.5 CDI74632.1 - 6 5.7 30.6 0.5 9.3 19.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) EBP50_C PF09007.11 CDI74632.1 - 6.9 7.7 32.1 3.4 8.7 18.3 2.3 2 0 0 2 2 2 0 EBP50, C-terminal CRT10 PF08728.10 CDI74632.1 - 7 4.7 15.4 0.56 8.3 5.7 2.0 2 0 0 2 2 2 0 CRT10 DUF3807 PF12720.7 CDI74632.1 - 7 6.9 58.8 5.5 7.2 13.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) LMBR1 PF04791.16 CDI74632.1 - 7.3 5.4 18.2 11 4.8 18.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Shadoo PF14999.6 CDI74632.1 - 7.9 6.6 19.3 0.18 11.9 6.1 2.4 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Gti1_Pac2 PF09729.9 CDI74632.1 - 8.3 6.5 37.0 5 7.2 22.9 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family NPR3 PF03666.13 CDI74632.1 - 8.5 5.0 44.0 3 6.5 27.3 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 K_channel_TID PF07941.11 CDI74633.1 - 0.03 14.8 6.4 0.03 14.8 6.4 9.2 7 4 2 9 9 9 0 Potassium channel Kv1.4 tandem inactivation domain DUF2158 PF09926.9 CDI74633.1 - 0.03 14.0 0.2 6 6.7 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized small protein (DUF2158) Exonuc_VII_L PF02601.15 CDI74633.1 - 0.11 12.1 0.1 0.11 12.1 0.1 2.7 2 1 0 2 2 2 0 Exonuclease VII, large subunit AUX_IAA PF02309.16 CDI74633.1 - 10 5.9 18.1 13 5.5 5.7 2.8 2 1 0 2 2 2 0 AUX/IAA family RabGAP-TBC PF00566.18 CDI74635.1 - 6.7e-31 107.6 2.1 3.1e-16 59.7 0.2 3.1 2 1 0 2 2 2 2 Rab-GTPase-TBC domain SlyX PF04102.12 CDI74635.1 - 0.18 12.4 2.5 24 5.6 1.1 2.8 2 0 0 2 2 2 0 SlyX Toxin_11 PF07473.11 CDI74635.1 - 0.29 11.2 2.2 22 5.3 0.2 2.5 2 0 0 2 2 2 0 Spasmodic peptide gm9a; conotoxin from Conus species SR-25 PF10500.9 CDI74636.1 - 0.0047 16.6 10.0 0.0047 16.6 10.0 8.9 8 1 0 8 8 8 3 Nuclear RNA-splicing-associated protein Herpes_UL7 PF01677.16 CDI74636.1 - 0.08 12.6 2.6 0.19 11.4 2.6 1.6 1 0 0 1 1 1 0 Herpesvirus UL7 like RVP_2 PF08284.11 CDI74637.1 - 0.025 14.3 0.0 0.05 13.4 0.0 1.5 1 1 0 1 1 1 0 Retroviral aspartyl protease DUF572 PF04502.13 CDI74639.1 - 0.0092 15.6 29.9 0.019 14.6 17.3 2.3 2 0 0 2 2 2 2 Family of unknown function (DUF572) Presenilin PF01080.17 CDI74639.1 - 1.2 7.8 40.8 2.2 7.0 22.8 2.4 2 0 0 2 2 2 0 Presenilin Caldesmon PF02029.15 CDI74639.1 - 7.1 5.3 33.8 0.59 8.8 19.3 2.2 2 0 0 2 2 2 0 Caldesmon Tic110 PF16940.5 CDI74640.1 - 0.21 10.0 2.6 0.25 9.8 2.6 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF572 PF04502.13 CDI74640.1 - 0.31 10.6 19.1 0.32 10.6 19.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) RIFIN PF02009.16 CDI74640.1 - 0.55 10.1 5.8 0.71 9.7 5.8 1.1 1 0 0 1 1 1 0 Rifin Hid1 PF12722.7 CDI74640.1 - 6.2 4.8 18.4 6.7 4.7 18.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SR-25 PF10500.9 CDI74641.1 - 0.001 18.7 7.2 0.001 18.7 7.2 2.1 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein GREB1 PF15782.5 CDI74641.1 - 0.0054 13.9 13.6 0.006 13.8 13.6 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer TFIIA PF03153.13 CDI74641.1 - 0.017 15.2 17.9 0.023 14.7 17.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 CDI74641.1 - 0.027 13.4 11.6 0.033 13.1 11.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Hydin_ADK PF17213.3 CDI74641.1 - 0.034 14.4 7.9 0.05 13.9 7.9 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Kelch_1 PF01344.25 CDI74641.1 - 0.05 13.2 6.4 3.4 7.3 6.4 2.6 1 1 0 1 1 1 0 Kelch motif CagX PF03524.15 CDI74641.1 - 0.053 13.2 2.4 0.061 13.0 2.4 1.1 1 0 0 1 1 1 0 Conjugal transfer protein Kelch_4 PF13418.6 CDI74641.1 - 0.1 12.6 0.1 4.8 7.3 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain Apc15p PF05841.11 CDI74641.1 - 0.14 13.0 13.4 0.8 10.5 10.9 2.1 2 0 0 2 2 2 0 Apc15p protein TCP PF03634.13 CDI74641.1 - 0.18 12.4 13.4 1.6 9.3 10.0 2.1 2 0 0 2 2 2 0 TCP family transcription factor Roughex PF06020.11 CDI74641.1 - 0.3 10.1 7.6 0.35 9.9 7.6 1.1 1 0 0 1 1 1 0 Drosophila roughex protein SUZ PF12752.7 CDI74641.1 - 0.4 11.5 0.1 0.4 11.5 0.1 3.1 2 1 0 2 2 1 0 SUZ domain Kelch_2 PF07646.15 CDI74641.1 - 0.5 10.4 7.2 22 5.3 7.2 2.7 1 1 0 1 1 1 0 Kelch motif Plasmodium_Vir PF05795.11 CDI74641.1 - 0.75 9.2 8.2 0.98 8.8 8.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PRC2_HTH_1 PF18118.1 CDI74641.1 - 0.77 10.6 7.4 0.36 11.7 4.3 1.9 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Lin-8 PF03353.15 CDI74641.1 - 1.4 8.4 17.7 2.4 7.7 17.7 1.3 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist Kelch_6 PF13964.6 CDI74641.1 - 2 8.9 8.4 8.1 6.9 4.4 2.9 3 1 0 3 3 1 0 Kelch motif DUF572 PF04502.13 CDI74641.1 - 2.2 7.8 12.6 2.9 7.4 12.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Miga PF10265.9 CDI74641.1 - 2.7 6.9 11.7 3.5 6.5 11.7 1.2 1 0 0 1 1 1 0 Mitoguardin GTA_holin_3TM PF11351.8 CDI74641.1 - 3.7 8.1 6.2 7.3 7.2 6.2 1.5 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release DUF5336 PF17270.2 CDI74641.1 - 4.2 7.0 8.3 3.6 7.2 5.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5336) SPX PF03105.19 CDI74641.1 - 5.1 6.9 15.8 7.7 6.3 15.8 1.2 1 0 0 1 1 1 0 SPX domain Clr2 PF10383.9 CDI74641.1 - 5.7 7.7 8.7 1 10.1 3.7 1.9 1 1 1 2 2 2 0 Transcription-silencing protein Clr2 Peptidase_S64 PF08192.11 CDI74641.1 - 8.2 4.8 17.7 11 4.4 17.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 Surface_antigen PF11054.8 CDI74642.1 - 2.6e-20 73.1 15.4 3.1e-07 30.3 0.3 6.5 2 2 1 3 3 3 3 Sporozoite TA4 surface antigen LZ3wCH PF18517.1 CDI74642.1 - 0.056 13.5 0.0 18 5.5 0.0 3.4 3 0 0 3 3 3 0 Leucine zipper with capping helix domain DBR1 PF05011.13 CDI74643.1 - 0.18 12.3 0.0 0.42 11.0 0.0 1.6 2 0 0 2 2 2 0 Lariat debranching enzyme, C-terminal domain Surface_antigen PF11054.8 CDI74644.1 - 2.6e-16 60.1 13.3 1.9e-05 24.5 3.0 5.1 1 1 2 3 3 3 3 Sporozoite TA4 surface antigen MT PF12777.7 CDI74644.1 - 0.067 12.2 0.1 0.13 11.3 0.1 1.4 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor SUIM_assoc PF16619.5 CDI74645.1 - 4.8e-06 26.5 0.3 4.8e-06 26.5 0.3 9.6 6 3 3 9 9 9 1 Unstructured region C-term to UIM in Ataxin3 N6_N4_Mtase PF01555.18 CDI74647.1 - 0.0007 19.4 0.0 91 2.6 0.2 4.4 4 1 0 4 4 4 0 DNA methylase Spt46 PF17734.1 CDI74647.1 - 0.18 11.6 6.9 0.39 10.5 0.1 3.5 2 1 1 3 3 3 0 Spermatogenesis-associated protein 46 WSS_VP PF12175.8 CDI74648.1 - 0.069 12.6 4.2 1.8 8.0 0.7 2.2 1 1 0 2 2 2 0 White spot syndrome virus structural envelope protein VP Plasmodium_Vir PF05795.11 CDI74649.1 - 0.061 12.7 10.5 0.034 13.6 2.9 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein FAM60A PF15396.6 CDI74649.1 - 0.067 13.2 8.6 0.091 12.8 2.3 2.5 2 0 0 2 2 2 0 Protein Family FAM60A Apt1 PF10351.9 CDI74649.1 - 0.22 10.3 24.1 0.03 13.2 4.9 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain Ecl1 PF12855.7 CDI74649.1 - 7.5 7.7 35.1 7.8 7.6 10.2 2.8 3 0 0 3 3 3 0 ECL1/2/3 zinc binding proteins A2M_recep PF07677.14 CDI74650.1 - 1.6 9.5 8.1 2.5e+02 2.4 8.1 2.6 1 1 0 1 1 1 0 A-macroglobulin receptor binding domain DUF560 PF04575.13 CDI74650.1 - 2 7.8 6.0 3.1 7.2 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF560) PulA_N1 PF17999.1 CDI74650.1 - 2.7 8.8 6.4 10 7.0 1.5 2.4 1 1 1 2 2 2 0 Pullulanase N1-terminal domain PRP38_assoc PF12871.7 CDI74651.1 - 0.011 16.4 69.9 0.027 15.1 24.7 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Presenilin PF01080.17 CDI74651.1 - 6 5.5 17.2 9 4.9 17.2 1.2 1 0 0 1 1 1 0 Presenilin TonB_N PF16031.5 CDI74652.1 - 0.00076 20.0 21.8 0.00076 20.0 21.8 2.1 3 0 0 3 3 3 1 TonB polyproline region Spt20 PF12090.8 CDI74652.1 - 0.0037 16.9 18.9 0.008 15.8 18.9 1.6 1 0 0 1 1 1 1 Spt20 family Trypan_PARP PF05887.11 CDI74652.1 - 0.0038 17.2 32.1 0.0038 17.2 32.1 2.7 2 1 0 2 2 2 2 Procyclic acidic repetitive protein (PARP) DUF2052 PF09747.9 CDI74652.1 - 0.47 10.6 28.1 0.13 12.4 23.2 2.0 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) PA26 PF04636.13 CDI74652.1 - 1.6 7.5 9.3 2.8 6.8 9.3 1.4 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4484 PF14831.6 CDI74652.1 - 2.7 8.0 14.7 4.1 7.4 14.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) SLC12 PF03522.15 CDI74652.1 - 8.5 5.3 17.3 12 4.7 17.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF2722 PF10846.8 CDI74653.1 - 0.0002 20.4 9.2 0.00025 20.1 9.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI74653.1 - 0.0012 19.2 2.0 0.002 18.5 2.0 1.4 1 1 0 1 1 1 1 Anti-sigma-K factor rskA MAP65_ASE1 PF03999.12 CDI74653.1 - 0.016 14.0 6.7 0.017 13.8 6.7 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) TFIIA PF03153.13 CDI74653.1 - 0.016 15.2 13.1 0.018 15.0 13.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI74653.1 - 0.045 12.5 13.5 0.043 12.5 13.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Apt1 PF10351.9 CDI74653.1 - 0.09 11.6 5.2 0.096 11.5 5.2 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Band_3_cyto PF07565.13 CDI74653.1 - 0.13 12.0 2.5 0.16 11.7 2.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Lin-8 PF03353.15 CDI74653.1 - 0.17 11.4 7.4 0.2 11.2 7.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF1645 PF07816.11 CDI74653.1 - 0.17 12.4 8.9 0.24 12.0 8.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) DUF3292 PF11696.8 CDI74653.1 - 0.23 9.8 2.0 0.28 9.5 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) AF-4 PF05110.13 CDI74653.1 - 0.67 8.0 15.9 0.91 7.5 15.9 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Presenilin PF01080.17 CDI74653.1 - 0.87 8.3 5.9 1 8.1 5.9 1.1 1 0 0 1 1 1 0 Presenilin Ufd2P_core PF10408.9 CDI74653.1 - 1.2 7.7 7.4 1.4 7.4 7.4 1.1 1 0 0 1 1 1 0 Ubiquitin elongating factor core LNP1 PF15419.6 CDI74653.1 - 1.5 9.0 13.6 1.8 8.8 13.6 1.1 1 0 0 1 1 1 0 Leukemia NUP98 fusion partner 1 DUF4175 PF13779.6 CDI74653.1 - 2 6.2 13.0 2.2 6.1 13.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SbcCD_C PF13558.6 CDI74653.1 - 2.2 8.6 6.0 0.12 12.7 0.9 1.6 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit CCDC24 PF15669.5 CDI74653.1 - 2.5 7.9 9.8 3.2 7.6 9.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family DUF4407 PF14362.6 CDI74653.1 - 2.7 7.2 8.6 3.6 6.8 8.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Herpes_pp85 PF04637.12 CDI74653.1 - 3.3 6.0 9.7 3.3 6.0 9.7 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) USP8_interact PF08941.10 CDI74653.1 - 8.2 6.2 9.8 11 5.8 9.8 1.2 1 0 0 1 1 1 0 USP8 interacting Peptidase_U57 PF05582.12 CDI74655.1 - 5.7 6.1 18.7 6.2 6.0 18.7 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Pex14_N PF04695.13 CDI74655.1 - 9.3 6.9 34.7 11 6.7 34.7 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SR-25 PF10500.9 CDI74656.1 - 0.28 10.7 33.6 2.6 7.6 33.6 1.9 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF5427 PF10310.9 CDI74656.1 - 0.79 8.6 33.1 0.9 8.4 33.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SURF2 PF05477.11 CDI74656.1 - 0.88 9.2 24.3 1.1 8.9 24.3 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) RskA PF10099.9 CDI74656.1 - 2.5 8.3 21.0 19 5.5 21.0 2.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA rRNA_processing PF08524.11 CDI74656.1 - 3.4 7.7 37.6 0.17 11.9 17.7 2.0 2 0 0 2 2 2 0 rRNA processing K_channel_TID PF07941.11 CDI74659.1 - 0.09 13.3 30.4 1.3 9.6 6.8 3.4 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain PAT1 PF09770.9 CDI74660.1 - 0.27 9.4 36.5 0.35 9.1 36.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MRP-S31 PF15433.6 CDI74660.1 - 2.5 7.7 16.2 19 4.8 14.1 2.1 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 PA26 PF04636.13 CDI74660.1 - 2.8 6.8 8.1 4.6 6.0 8.1 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SLC12 PF03522.15 CDI74660.1 - 3.4 6.6 11.4 5.1 6.0 11.4 1.3 1 0 0 1 1 1 0 Solute carrier family 12 SART-1 PF03343.13 CDI74660.1 - 6.2 5.2 18.8 10 4.5 18.8 1.3 1 0 0 1 1 1 0 SART-1 family DUF2232 PF09991.9 CDI74662.1 - 0.00029 20.1 4.1 0.00036 19.8 4.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2232) Connexin PF00029.19 CDI74662.1 - 0.00058 19.7 6.0 0.00071 19.4 6.0 1.1 1 0 0 1 1 1 1 Connexin FAM176 PF14851.6 CDI74662.1 - 0.00079 19.1 3.0 0.001 18.8 3.0 1.2 1 0 0 1 1 1 1 FAM176 family OATP PF03137.20 CDI74662.1 - 0.00087 17.7 3.1 0.0011 17.4 3.1 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family FAM60A PF15396.6 CDI74662.1 - 0.00092 19.3 6.6 0.00099 19.2 6.6 1.1 1 0 0 1 1 1 1 Protein Family FAM60A RR_TM4-6 PF06459.12 CDI74662.1 - 0.0012 18.8 10.2 0.0013 18.6 10.2 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 SID-1_RNA_chan PF13965.6 CDI74662.1 - 0.0017 16.8 4.6 0.002 16.6 4.6 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DcuA_DcuB PF03605.14 CDI74662.1 - 0.0018 17.3 5.9 0.0023 16.9 5.9 1.1 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter SpoIIP PF07454.11 CDI74662.1 - 0.0019 17.7 9.4 0.002 17.7 9.4 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) DUF719 PF05334.13 CDI74662.1 - 0.002 18.4 10.7 0.0022 18.2 10.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF719) HCO3_cotransp PF00955.21 CDI74662.1 - 0.0022 16.9 4.4 0.0023 16.9 4.4 1.0 1 0 0 1 1 1 1 HCO3- transporter family TFIIA PF03153.13 CDI74662.1 - 0.0028 17.7 39.2 0.0033 17.5 39.2 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI74662.1 - 0.003 17.6 15.6 0.0034 17.4 15.6 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) OrfB_IS605 PF01385.19 CDI74662.1 - 0.0035 17.6 1.4 0.0039 17.4 1.4 1.1 1 0 0 1 1 1 1 Probable transposase DDHD PF02862.17 CDI74662.1 - 0.0041 17.3 7.9 0.0042 17.3 7.9 1.1 1 0 0 1 1 1 1 DDHD domain CBP_BcsG PF11658.8 CDI74662.1 - 0.0044 15.5 11.6 0.0051 15.3 11.6 1.0 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG DUF913 PF06025.12 CDI74662.1 - 0.0045 16.0 5.8 0.0049 15.9 5.8 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Serinc PF03348.15 CDI74662.1 - 0.0047 15.9 6.6 0.0058 15.6 6.6 1.2 1 0 0 1 1 1 1 Serine incorporator (Serinc) CLN3 PF02487.17 CDI74662.1 - 0.0058 15.7 6.4 0.0067 15.5 6.4 1.1 1 0 0 1 1 1 1 CLN3 protein Velvet PF11754.8 CDI74662.1 - 0.006 16.6 11.6 0.0066 16.4 11.6 1.1 1 0 0 1 1 1 1 Velvet factor Bac_luciferase PF00296.20 CDI74662.1 - 0.0071 15.8 5.6 0.0086 15.5 5.6 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase EMC3_TMCO1 PF01956.16 CDI74662.1 - 0.0075 16.0 8.8 0.0091 15.7 8.8 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like GET2 PF08690.10 CDI74662.1 - 0.0084 15.8 9.4 0.011 15.4 9.4 1.2 1 0 0 1 1 1 1 GET complex subunit GET2 MecA PF05389.12 CDI74662.1 - 0.0084 15.8 5.2 0.0088 15.7 5.2 1.1 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) RP-C_C PF11800.8 CDI74662.1 - 0.0091 16.1 10.4 0.011 15.9 10.4 1.1 1 0 0 1 1 1 1 Replication protein C C-terminal region DUF2370 PF10176.9 CDI74662.1 - 0.0095 15.6 4.1 0.011 15.4 4.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) Peptidase_S49_N PF08496.10 CDI74662.1 - 0.0098 16.0 9.0 0.012 15.7 9.0 1.2 1 0 0 1 1 1 1 Peptidase family S49 N-terminal V_ATPase_I PF01496.19 CDI74662.1 - 0.01 13.8 10.0 0.011 13.7 10.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5523 PF17661.1 CDI74662.1 - 0.011 15.5 9.6 0.012 15.3 9.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) OPT PF03169.15 CDI74662.1 - 0.011 14.4 0.1 0.013 14.1 0.1 1.2 1 0 0 1 1 1 0 OPT oligopeptide transporter protein AIF_C PF14721.6 CDI74662.1 - 0.011 16.1 7.9 0.014 15.7 7.9 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TERB2 PF15101.6 CDI74662.1 - 0.012 15.7 16.7 0.014 15.4 16.7 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF1980 PF09323.10 CDI74662.1 - 0.012 15.5 6.3 0.015 15.2 6.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) PalH PF08733.10 CDI74662.1 - 0.013 14.5 1.2 0.018 14.0 1.2 1.2 1 0 0 1 1 1 0 PalH/RIM21 CobT PF06213.12 CDI74662.1 - 0.014 14.8 18.4 0.017 14.6 18.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT ArsP_2 PF11449.8 CDI74662.1 - 0.014 14.6 3.6 0.021 14.0 3.6 1.3 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter RIC3 PF15361.6 CDI74662.1 - 0.017 15.5 5.7 0.019 15.4 5.7 1.2 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 EOS1 PF12326.8 CDI74662.1 - 0.018 15.0 4.9 0.023 14.6 4.9 1.2 1 0 0 1 1 1 0 N-glycosylation protein SLC12 PF03522.15 CDI74662.1 - 0.02 13.9 9.0 0.021 13.9 9.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 CDI74662.1 - 0.02 13.2 6.4 0.022 13.0 6.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Orf78 PF06024.12 CDI74662.1 - 0.021 15.1 10.5 0.052 13.8 10.5 1.8 1 1 0 1 1 1 0 Orf78 (ac78) Peptidase_M56 PF05569.11 CDI74662.1 - 0.022 14.0 4.5 0.025 13.8 4.5 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 CCDC53 PF10152.9 CDI74662.1 - 0.022 15.2 14.2 0.03 14.8 14.2 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex AF-4 PF05110.13 CDI74662.1 - 0.023 12.8 13.7 0.025 12.7 13.7 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CSG2 PF16965.5 CDI74662.1 - 0.024 13.6 6.1 0.028 13.4 6.1 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Peroxin-13_N PF04088.13 CDI74662.1 - 0.026 14.8 3.7 0.036 14.4 3.7 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region LAP1C PF05609.12 CDI74662.1 - 0.03 13.4 13.5 0.034 13.2 13.5 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) FemAB PF02388.16 CDI74662.1 - 0.031 13.2 10.6 0.037 12.9 10.6 1.1 1 0 0 1 1 1 0 FemAB family Peptidase_S15 PF02129.18 CDI74662.1 - 0.032 13.8 11.2 0.04 13.5 11.2 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Ctr PF04145.15 CDI74662.1 - 0.033 14.8 5.3 0.042 14.5 5.3 1.2 1 0 0 1 1 1 0 Ctr copper transporter family AI-2E_transport PF01594.16 CDI74662.1 - 0.034 13.3 0.3 0.043 13.0 0.3 1.1 1 0 0 1 1 1 0 AI-2E family transporter UPF0139 PF03669.13 CDI74662.1 - 0.035 14.0 1.9 0.035 14.0 1.9 1.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0139) BAF1_ABF1 PF04684.13 CDI74662.1 - 0.035 13.2 17.4 0.045 12.8 17.4 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor WTX PF09422.10 CDI74662.1 - 0.037 13.1 7.2 0.044 12.9 7.2 1.0 1 0 0 1 1 1 0 WTX protein Band_3_cyto PF07565.13 CDI74662.1 - 0.037 13.8 9.3 0.041 13.7 9.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Eapp_C PF10238.9 CDI74662.1 - 0.038 14.1 14.3 0.055 13.5 14.3 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein CPSF100_C PF13299.6 CDI74662.1 - 0.038 14.2 10.8 0.047 13.9 10.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Consortin_C PF15281.6 CDI74662.1 - 0.04 13.9 1.7 0.051 13.6 1.7 1.3 1 0 0 1 1 1 0 Consortin C-terminus DUF2828 PF11443.8 CDI74662.1 - 0.042 11.9 11.6 0.047 11.8 11.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PPL5 PF18168.1 CDI74662.1 - 0.045 13.1 5.8 0.049 12.9 5.8 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Endostatin PF06482.11 CDI74662.1 - 0.05 13.1 11.8 0.054 13.0 11.8 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin EPL1 PF10513.9 CDI74662.1 - 0.054 13.9 12.1 0.068 13.6 12.1 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like LMBR1 PF04791.16 CDI74662.1 - 0.061 12.2 3.8 0.072 12.0 3.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4471 PF14740.6 CDI74662.1 - 0.067 12.4 6.1 0.074 12.3 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) Pox_P35 PF03213.14 CDI74662.1 - 0.07 12.3 3.2 0.083 12.1 3.2 1.0 1 0 0 1 1 1 0 Poxvirus P35 protein LIM_bind PF01803.16 CDI74662.1 - 0.076 12.5 10.8 0.08 12.5 10.8 1.1 1 0 0 1 1 1 0 LIM-domain binding protein NARP1 PF12569.8 CDI74662.1 - 0.087 11.7 12.6 0.1 11.5 12.6 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 ADP_ribosyl_GH PF03747.14 CDI74662.1 - 0.089 12.5 4.9 0.13 12.0 4.9 1.2 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase Gti1_Pac2 PF09729.9 CDI74662.1 - 0.094 12.8 8.7 0.11 12.6 8.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Kei1 PF08552.11 CDI74662.1 - 0.096 12.6 14.3 0.14 12.0 14.3 1.3 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Neur_chan_memb PF02932.16 CDI74662.1 - 0.1 12.6 7.9 0.12 12.4 7.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PAT1 PF09770.9 CDI74662.1 - 0.11 10.8 26.6 0.12 10.7 26.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_U57 PF05582.12 CDI74662.1 - 0.11 11.7 8.4 0.13 11.5 8.4 1.1 1 0 0 1 1 1 0 YabG peptidase U57 NPR3 PF03666.13 CDI74662.1 - 0.11 11.3 11.1 0.13 11.0 11.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2126 PF09899.9 CDI74662.1 - 0.12 10.4 9.7 0.13 10.3 9.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) MMR1 PF08505.10 CDI74662.1 - 0.14 12.5 16.2 0.15 12.3 16.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF4045 PF13254.6 CDI74662.1 - 0.14 11.8 12.9 0.15 11.7 12.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Rtf2 PF04641.12 CDI74662.1 - 0.14 11.5 11.8 0.18 11.2 11.8 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Ndc1_Nup PF09531.10 CDI74662.1 - 0.15 10.7 9.7 0.16 10.6 9.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup O-antigen_lig PF13425.6 CDI74662.1 - 0.16 10.7 3.3 0.18 10.5 3.3 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein eIF-3_zeta PF05091.12 CDI74662.1 - 0.16 10.9 19.4 0.18 10.7 19.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ALMT PF11744.8 CDI74662.1 - 0.17 10.7 7.1 0.18 10.6 7.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PcfK PF14058.6 CDI74662.1 - 0.17 12.2 15.9 0.22 11.8 15.9 1.2 1 0 0 1 1 1 0 PcfK-like protein DUF4228 PF14009.6 CDI74662.1 - 0.17 12.3 6.1 0.23 11.9 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Lin-8 PF03353.15 CDI74662.1 - 0.18 11.3 16.3 0.21 11.1 16.3 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SelP_N PF04592.14 CDI74662.1 - 0.2 11.1 14.7 0.24 10.7 14.7 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PIP5K PF01504.18 CDI74662.1 - 0.22 10.7 9.9 0.25 10.5 9.9 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF4770 PF15994.5 CDI74662.1 - 0.23 11.7 12.1 0.27 11.5 12.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Trp_oprn_chp PF09534.10 CDI74662.1 - 0.25 11.1 19.0 2.1 8.1 19.0 1.9 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Pex14_N PF04695.13 CDI74662.1 - 0.25 12.0 36.2 0.59 10.8 36.2 1.5 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RICTOR_N PF14664.6 CDI74662.1 - 0.26 10.2 4.0 0.32 10.0 4.0 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term SARAF PF06682.12 CDI74662.1 - 0.27 10.8 14.3 0.35 10.5 14.3 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Paramyxo_ncap PF00973.19 CDI74662.1 - 0.27 10.1 8.9 0.31 9.9 8.9 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Peptidase_S64 PF08192.11 CDI74662.1 - 0.28 9.6 9.8 0.32 9.4 9.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 2HCT PF03390.15 CDI74662.1 - 0.29 9.7 9.2 3.4 6.2 9.2 1.9 1 1 0 1 1 1 0 2-hydroxycarboxylate transporter family BORG_CEP PF14957.6 CDI74662.1 - 0.29 12.3 8.0 0.35 12.1 8.0 1.1 1 0 0 1 1 1 0 Cdc42 effector Ureide_permease PF07168.11 CDI74662.1 - 0.3 9.8 6.0 0.38 9.5 6.0 1.2 1 0 0 1 1 1 0 Ureide permease Scs3p PF10261.9 CDI74662.1 - 0.32 10.5 3.4 0.36 10.3 3.4 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM MMU163 PF17119.5 CDI74662.1 - 0.33 10.1 5.2 0.37 9.9 5.2 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis MRI PF15325.6 CDI74662.1 - 0.35 12.0 4.9 0.49 11.5 4.9 1.2 1 0 0 1 1 1 0 Modulator of retrovirus infection Sec62 PF03839.16 CDI74662.1 - 0.37 10.3 9.2 0.46 10.0 9.2 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 EIF4E-T PF10477.9 CDI74662.1 - 0.41 9.4 21.8 0.45 9.3 21.8 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Med15 PF09606.10 CDI74662.1 - 0.41 9.3 34.7 0.6 8.7 34.7 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Renin_r PF07850.14 CDI74662.1 - 0.42 11.2 8.0 0.91 10.2 8.0 1.6 1 1 0 1 1 1 0 Renin receptor-like protein DUF2464 PF10240.9 CDI74662.1 - 0.45 10.1 11.7 0.55 9.7 11.7 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 Claudin_2 PF13903.6 CDI74662.1 - 0.49 10.1 7.8 0.098 12.4 1.1 2.0 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction PGA_cap PF09587.10 CDI74662.1 - 0.51 9.7 7.5 0.65 9.4 7.5 1.2 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap AAT PF03417.16 CDI74662.1 - 0.54 9.9 7.9 0.64 9.7 7.9 1.1 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Glt_symporter PF03616.14 CDI74662.1 - 0.59 8.7 10.9 1.4 7.5 10.9 1.6 1 1 0 1 1 1 0 Sodium/glutamate symporter CCDC117 PF15810.5 CDI74662.1 - 0.66 10.3 12.7 0.83 10.0 12.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 117 MAJIN PF15077.6 CDI74662.1 - 0.68 9.7 7.3 0.74 9.6 7.3 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF3295 PF11702.8 CDI74662.1 - 0.69 9.2 17.0 0.77 9.0 17.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Paf1 PF03985.13 CDI74662.1 - 0.74 8.7 15.8 0.87 8.5 15.8 1.0 1 0 0 1 1 1 0 Paf1 BNR_3 PF13859.6 CDI74662.1 - 0.77 9.0 9.1 0.94 8.7 9.1 1.1 1 0 0 1 1 1 0 BNR repeat-like domain Tim54 PF11711.8 CDI74662.1 - 0.8 8.4 14.8 0.98 8.1 14.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TMEM223 PF14640.6 CDI74662.1 - 0.81 9.8 6.5 12 6.0 6.5 2.1 1 1 0 1 1 1 0 Transmembrane protein 223 DUF5427 PF10310.9 CDI74662.1 - 0.86 8.5 18.2 0.95 8.3 18.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) CrgA PF06781.12 CDI74662.1 - 0.88 9.7 9.1 12 6.1 8.4 2.3 1 1 0 1 1 1 0 Cell division protein CrgA 7tm_1 PF00001.21 CDI74662.1 - 0.91 8.8 6.9 2 7.7 6.9 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Dicty_REP PF05086.12 CDI74662.1 - 0.94 7.4 15.7 1.1 7.2 15.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Baculo_PP31 PF05311.11 CDI74662.1 - 1 8.8 15.4 1.2 8.6 15.4 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF4746 PF15928.5 CDI74662.1 - 1.1 8.6 9.8 1.3 8.3 9.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) NapE PF06796.11 CDI74662.1 - 1.2 8.7 3.8 8.4 6.0 3.8 2.3 1 1 0 1 1 1 0 Periplasmic nitrate reductase protein NapE F-protein PF00469.20 CDI74662.1 - 1.3 8.5 10.3 1.6 8.3 10.3 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef GREB1 PF15782.5 CDI74662.1 - 1.3 6.0 15.9 1.4 5.9 15.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4457 PF14652.6 CDI74662.1 - 1.4 8.1 8.2 1.9 7.7 8.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) Spc7_N PF15402.6 CDI74662.1 - 1.5 7.0 14.4 1.7 6.8 14.4 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 CD20 PF04103.15 CDI74662.1 - 1.5 8.9 10.4 24 5.0 10.4 2.0 1 1 0 1 1 1 0 CD20-like family Nucleoside_tran PF01733.18 CDI74662.1 - 1.6 8.1 10.0 4 6.7 10.1 1.6 1 1 1 2 2 2 0 Nucleoside transporter DUF4192 PF13830.6 CDI74662.1 - 1.6 8.7 17.0 2.1 8.3 17.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) MCU PF04678.13 CDI74662.1 - 1.9 8.5 14.1 2.4 8.2 14.1 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF3357 PF11837.8 CDI74662.1 - 2.2 8.8 11.4 4.1 7.9 8.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) MDM31_MDM32 PF08118.11 CDI74662.1 - 2.2 6.9 9.7 2.6 6.6 9.7 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins FAM222A PF15258.6 CDI74662.1 - 2.3 7.2 29.4 2.9 6.9 29.4 1.0 1 0 0 1 1 1 0 Protein family of FAM222A TMEM154 PF15102.6 CDI74662.1 - 2.5 8.0 9.0 6.5 6.6 9.0 1.6 1 1 0 1 1 1 0 TMEM154 protein family TFB6 PF17110.5 CDI74662.1 - 2.7 7.7 8.2 3.5 7.3 8.2 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF1387 PF07139.11 CDI74662.1 - 2.8 7.6 16.1 3.4 7.3 16.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) REC114-like PF15165.6 CDI74662.1 - 3 7.6 19.8 3.7 7.3 19.8 1.3 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like DUF3408 PF11888.8 CDI74662.1 - 3 8.0 18.4 4.5 7.4 18.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Spore_coat_CotO PF14153.6 CDI74662.1 - 3.1 7.7 26.7 4 7.3 26.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO INSIG PF07281.12 CDI74662.1 - 3.2 7.3 9.1 8.8 5.9 9.1 1.7 1 1 0 1 1 1 0 Insulin-induced protein (INSIG) DUF4446 PF14584.6 CDI74662.1 - 3.2 7.7 7.3 2.1 8.3 6.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) DUF4079 PF13301.6 CDI74662.1 - 3.5 7.8 6.9 82 3.3 6.9 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) eIF3_subunit PF08597.10 CDI74662.1 - 3.7 7.4 20.9 4.6 7.1 20.9 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF4366 PF14283.6 CDI74662.1 - 4.4 7.3 16.3 16 5.5 16.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) UPF0560 PF10577.9 CDI74662.1 - 4.4 5.7 23.4 5.1 5.5 23.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Hid1 PF12722.7 CDI74662.1 - 4.6 5.2 16.3 5.3 5.0 16.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein YjbH PF06082.11 CDI74662.1 - 4.7 5.9 12.9 5.4 5.7 12.9 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH DUF1180 PF06679.12 CDI74662.1 - 5.5 7.4 9.6 8.4 6.8 9.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF4638 PF15472.6 CDI74662.1 - 5.6 6.6 12.3 6.6 6.4 12.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) HemX PF04375.14 CDI74662.1 - 5.9 6.1 36.9 7.5 5.7 36.9 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase ORC_WH_C PF18137.1 CDI74662.1 - 6.7 6.8 14.6 9.2 6.3 14.6 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Helicase_RecD PF05127.14 CDI74662.1 - 7.4 6.4 12.8 9.6 6.0 12.8 1.1 1 0 0 1 1 1 0 Helicase HEV_ORF1 PF02444.16 CDI74662.1 - 7.9 7.1 9.1 0.65 10.6 1.7 2.0 2 0 0 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) DUF4386 PF14329.6 CDI74662.1 - 9.1 6.1 13.5 3.7e+02 0.8 13.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4386) Hydin_ADK PF17213.3 CDI74663.1 - 2.8 8.2 22.8 6.6 7.0 0.9 4.3 4 0 0 4 4 4 0 Hydin Adenylate kinase-like domain M20_dimer PF07687.14 CDI74665.1 - 0.0044 16.9 4.3 0.89 9.5 0.0 3.9 2 1 1 3 3 3 2 Peptidase dimerisation domain Adenyl_cycl_N PF12633.7 CDI74666.1 - 2.9 7.8 19.1 2.8 7.8 0.0 4.8 5 0 0 5 5 5 0 Adenylate cyclase NT domain PAT1 PF09770.9 CDI74666.1 - 6 5.0 31.7 1 7.5 21.3 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Gastrin PF00918.17 CDI74667.1 - 1.3 10.0 4.5 7.7 7.5 2.3 2.7 2 0 0 2 2 2 0 Gastrin/cholecystokinin family zf-CCCH PF00642.24 CDI74669.1 - 1e-10 41.2 13.7 2.1e-05 24.3 1.9 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CDI74669.1 - 4.4e-05 24.1 1.1 0.12 13.1 0.1 2.5 2 0 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 CDI74669.1 - 4.5e-05 23.3 15.9 0.011 15.7 5.7 2.6 2 0 0 2 2 2 2 Zinc finger domain RRM_1 PF00076.22 CDI74669.1 - 7.4e-05 22.5 0.0 0.00014 21.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_3 PF15663.5 CDI74669.1 - 0.032 14.4 2.3 3.9 7.7 0.3 2.4 2 0 0 2 2 2 0 Zinc-finger containing family zf-CCCH_4 PF18044.1 CDI74669.1 - 1.4 8.8 16.2 3.1 7.7 6.6 2.4 2 0 0 2 2 2 0 CCCH-type zinc finger Rhodanese PF00581.20 CDI74670.1 - 0.001 19.5 0.0 2.1 8.9 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Pkinase PF00069.25 CDI74671.1 - 2.8e-14 53.1 0.0 6.5e-08 32.3 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI74671.1 - 5.8e-07 29.1 0.0 1.3e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI74671.1 - 0.0093 15.3 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DUF4228 PF14009.6 CDI74673.1 - 0.003 18.0 4.8 0.0035 17.8 4.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4228) TraG-D_C PF12696.7 CDI74673.1 - 0.0095 15.9 5.9 0.0095 15.9 5.9 1.7 2 0 0 2 2 2 1 TraM recognition site of TraD and TraG T4SS-DNA_transf PF02534.14 CDI74673.1 - 0.014 14.2 5.6 0.015 14.1 5.6 1.1 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer Dehydrin PF00257.19 CDI74673.1 - 0.018 15.6 5.8 0.018 15.6 5.8 1.8 2 0 0 2 2 2 0 Dehydrin FHIPEP PF00771.20 CDI74673.1 - 0.2 10.1 7.5 0.25 9.8 7.5 1.1 1 0 0 1 1 1 0 FHIPEP family NINJA_B PF16136.5 CDI74673.1 - 0.23 11.9 14.6 0.18 12.2 7.4 2.1 2 0 0 2 2 2 0 Putative nuclear localisation signal Plexin_cytopl PF08337.12 CDI74673.1 - 0.34 9.5 9.1 0.4 9.3 9.1 1.0 1 0 0 1 1 1 0 Plexin cytoplasmic RasGAP domain DUF4551 PF15087.6 CDI74673.1 - 0.86 8.4 14.9 1 8.1 14.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) IHABP4_N PF16174.5 CDI74673.1 - 0.98 10.0 20.0 1.3 9.6 20.0 1.1 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Presenilin PF01080.17 CDI74673.1 - 1.5 7.5 19.8 1.8 7.2 19.8 1.0 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 CDI74673.1 - 1.9 6.7 11.3 2.2 6.5 11.3 1.0 1 0 0 1 1 1 0 CDC45-like protein SVIP PF15811.5 CDI74673.1 - 2.5 8.6 20.8 2.3 8.7 10.7 2.2 2 0 0 2 2 2 0 Small VCP/p97-interacting protein SMYLE_N PF18615.1 CDI74673.1 - 2.7 7.4 11.5 3.2 7.2 11.5 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain FAM60A PF15396.6 CDI74673.1 - 3 7.8 10.6 4.4 7.3 10.6 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF5521 PF17659.1 CDI74673.1 - 3.4 5.4 13.6 3.8 5.2 13.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5521) ALMT PF11744.8 CDI74673.1 - 4.4 6.0 11.5 5.5 5.7 11.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter UPF0524 PF15823.5 CDI74673.1 - 4.5 6.6 13.7 0.42 10.0 0.2 2.1 1 1 1 2 2 2 0 UPF0524 of C3orf70 Zip PF02535.22 CDI74673.1 - 4.6 6.4 6.9 5.9 6.0 6.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 CDI74673.1 - 5.3 6.8 15.2 7.6 6.3 15.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PA26 PF04636.13 CDI74673.1 - 5.8 5.7 10.3 7.1 5.4 10.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) FKBP_N PF01346.18 CDI74673.1 - 6.1 7.9 20.0 0.9 10.5 9.4 2.1 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase MIIP PF15734.5 CDI74673.1 - 6.2 6.2 16.1 7.8 5.9 16.1 1.0 1 0 0 1 1 1 0 Migration and invasion-inhibitory AIM3 PF17096.5 CDI74673.1 - 6.3 7.8 13.4 2.8 8.9 11.0 1.6 1 1 1 2 2 2 0 Altered inheritance of mitochondria protein 3 Presenilin PF01080.17 CDI74675.1 - 0.0021 16.9 10.4 0.0021 16.9 10.4 1.5 2 0 0 2 2 2 1 Presenilin Connexin PF00029.19 CDI74675.1 - 0.29 10.9 0.0 0.29 10.9 0.0 2.1 1 1 1 2 2 2 0 Connexin EOS1 PF12326.8 CDI74675.1 - 1.6 8.6 11.4 0.077 12.9 1.0 2.3 2 0 0 2 2 2 0 N-glycosylation protein Orf78 PF06024.12 CDI74675.1 - 2.2 8.6 7.2 1.9 8.8 0.1 2.8 2 0 0 2 2 2 0 Orf78 (ac78) EPL1 PF10513.9 CDI74675.1 - 7.5 6.9 14.1 3.4 8.0 0.7 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like Gti1_Pac2 PF09729.9 CDI74676.1 - 0.00034 20.7 8.2 0.00034 20.7 8.2 4.3 2 1 0 2 2 2 1 Gti1/Pac2 family Activator_LAG-3 PF11498.8 CDI74676.1 - 0.0088 15.1 17.1 0.0088 15.1 17.1 3.1 3 0 0 3 3 3 2 Transcriptional activator LAG-3 RskA PF10099.9 CDI74676.1 - 0.031 14.6 0.0 0.031 14.6 0.0 4.2 2 2 1 4 4 4 0 Anti-sigma-K factor rskA FHIPEP PF00771.20 CDI74676.1 - 0.061 11.8 7.4 0.071 11.6 0.5 2.3 2 0 0 2 2 2 0 FHIPEP family WBP-1 PF11669.8 CDI74676.1 - 0.54 10.9 8.2 0.45 11.2 0.2 3.0 2 0 0 2 2 2 0 WW domain-binding protein 1 NEMP PF10225.9 CDI74676.1 - 1.5 8.5 15.2 0.54 9.9 6.2 2.9 2 0 0 2 2 2 0 NEMP family Scs3p PF10261.9 CDI74676.1 - 2.7 7.4 7.2 1.2 8.5 0.9 2.5 2 0 0 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM Spt20 PF12090.8 CDI74676.1 - 7.3 6.1 88.2 0.018 14.7 31.0 3.6 4 0 0 4 4 4 0 Spt20 family EKR PF10371.9 CDI74677.1 - 0.34 10.7 2.8 7.9 6.4 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function SUIM_assoc PF16619.5 CDI74678.1 - 0.023 14.8 0.0 0.023 14.8 0.0 6.8 3 2 1 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 RPN2_C PF18004.1 CDI74679.1 - 0.016 15.1 11.2 0.018 15.0 11.2 1.0 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain LRRC37AB_C PF14914.6 CDI74679.1 - 0.038 13.9 11.7 0.042 13.8 11.7 1.0 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain CobT PF06213.12 CDI74679.1 - 0.085 12.2 17.5 0.09 12.1 17.5 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CLN3 PF02487.17 CDI74679.1 - 0.093 11.8 6.7 0.09 11.8 6.7 1.0 1 0 0 1 1 1 0 CLN3 protein HA2 PF04408.23 CDI74679.1 - 0.1 12.9 3.1 0.14 12.5 3.1 1.3 1 0 0 1 1 1 0 Helicase associated domain (HA2) DDHD PF02862.17 CDI74679.1 - 0.13 12.4 10.0 0.12 12.5 10.0 1.0 1 0 0 1 1 1 0 DDHD domain NARP1 PF12569.8 CDI74679.1 - 0.17 10.7 15.2 0.18 10.7 15.2 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF913 PF06025.12 CDI74679.1 - 0.21 10.5 6.9 0.21 10.6 6.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Eapp_C PF10238.9 CDI74679.1 - 0.27 11.3 14.5 0.32 11.1 14.5 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF3408 PF11888.8 CDI74679.1 - 0.28 11.3 14.8 0.3 11.2 14.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) TFB6 PF17110.5 CDI74679.1 - 0.28 10.9 7.5 0.33 10.7 7.5 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RR_TM4-6 PF06459.12 CDI74679.1 - 0.31 10.8 13.7 0.3 10.9 13.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM176 PF14851.6 CDI74679.1 - 0.31 10.7 7.8 0.34 10.6 7.8 1.1 1 0 0 1 1 1 0 FAM176 family SpoIIP PF07454.11 CDI74679.1 - 0.37 10.2 14.6 0.38 10.2 14.6 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4746 PF15928.5 CDI74679.1 - 0.48 9.8 11.8 0.5 9.7 11.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) OATP PF03137.20 CDI74679.1 - 0.63 8.2 6.7 0.67 8.2 6.7 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Endostatin PF06482.11 CDI74679.1 - 0.76 9.2 13.6 0.75 9.2 13.6 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin eIF-3_zeta PF05091.12 CDI74679.1 - 0.94 8.4 18.7 0.91 8.4 18.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CPSF100_C PF13299.6 CDI74679.1 - 1.1 9.5 10.9 1.1 9.4 10.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Peroxin-13_N PF04088.13 CDI74679.1 - 1.1 9.5 9.1 1.4 9.2 9.1 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region BORG_CEP PF14957.6 CDI74679.1 - 1.2 10.3 9.9 1.3 10.2 9.9 1.1 1 0 0 1 1 1 0 Cdc42 effector AIF_C PF14721.6 CDI74679.1 - 1.4 9.3 10.4 1.6 9.1 10.4 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FHIPEP PF00771.20 CDI74679.1 - 1.4 7.3 5.9 1.4 7.3 5.9 1.1 1 0 0 1 1 1 0 FHIPEP family DUF1764 PF08576.10 CDI74679.1 - 1.7 9.6 13.6 2.1 9.3 13.6 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Serinc PF03348.15 CDI74679.1 - 1.7 7.5 7.8 1.7 7.5 7.8 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Baculo_PP31 PF05311.11 CDI74679.1 - 1.8 8.0 13.4 1.8 8.0 13.4 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Peptidase_U57 PF05582.12 CDI74679.1 - 1.9 7.6 10.0 2.1 7.5 10.0 1.0 1 0 0 1 1 1 0 YabG peptidase U57 eIF_4EBP PF05456.11 CDI74679.1 - 2.2 8.2 15.7 4.7 7.2 15.7 1.6 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Tim54 PF11711.8 CDI74679.1 - 2.6 6.7 16.1 2.7 6.7 16.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Presenilin PF01080.17 CDI74679.1 - 2.8 6.6 17.3 2.8 6.6 17.3 1.0 1 0 0 1 1 1 0 Presenilin TERB2 PF15101.6 CDI74679.1 - 3 7.8 19.6 3 7.9 19.6 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Orf78 PF06024.12 CDI74679.1 - 3.4 8.0 6.6 4.4 7.6 6.6 1.3 1 0 0 1 1 1 0 Orf78 (ac78) G0-G1_switch_2 PF15103.6 CDI74679.1 - 3.8 8.0 10.5 4.7 7.7 10.5 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 DUF2828 PF11443.8 CDI74679.1 - 4.1 5.4 14.6 4.1 5.4 14.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Ureide_permease PF07168.11 CDI74679.1 - 4.4 6.0 6.1 4.5 5.9 6.1 1.0 1 0 0 1 1 1 0 Ureide permease NEMP PF10225.9 CDI74679.1 - 4.6 6.8 6.0 5.1 6.7 6.0 1.1 1 0 0 1 1 1 0 NEMP family SID-1_RNA_chan PF13965.6 CDI74679.1 - 4.8 5.5 6.4 5 5.4 6.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 LMBR1 PF04791.16 CDI74679.1 - 5 5.9 10.2 5.3 5.8 10.2 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 CDI74679.1 - 5.5 6.3 15.4 5.5 6.3 15.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EOS1 PF12326.8 CDI74679.1 - 5.7 6.8 7.6 6.6 6.6 7.6 1.1 1 0 0 1 1 1 0 N-glycosylation protein CSG2 PF16965.5 CDI74679.1 - 6.2 5.7 7.6 6.7 5.5 7.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator V_ATPase_I PF01496.19 CDI74679.1 - 6.3 4.6 17.6 6.6 4.5 17.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 CDI74679.1 - 6.5 6.4 13.5 6.8 6.4 13.5 1.1 1 0 0 1 1 1 0 Connexin Ctr PF04145.15 CDI74679.1 - 7 7.3 10.1 7.1 7.2 10.1 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Band_3_cyto PF07565.13 CDI74679.1 - 8.1 6.2 13.9 8 6.2 13.9 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Folate_carrier PF01770.18 CDI74679.1 - 8.4 5.0 8.4 8.7 5.0 8.4 1.0 1 0 0 1 1 1 0 Reduced folate carrier DDRGK PF09756.9 CDI74679.1 - 9.5 5.8 24.8 12 5.5 24.8 1.0 1 0 0 1 1 1 0 DDRGK domain Dsh_C PF12316.8 CDI74680.1 - 0.0094 16.4 15.6 0.016 15.6 15.6 1.3 1 0 0 1 1 1 1 Segment polarity protein dishevelled (Dsh) C terminal SPT6_acidic PF14632.6 CDI74680.1 - 0.083 13.5 6.5 0.084 13.5 5.3 1.6 1 1 0 1 1 1 0 Acidic N-terminal SPT6 Vfa1 PF08432.10 CDI74680.1 - 0.095 13.0 22.3 0.12 12.7 22.3 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Apt1 PF10351.9 CDI74680.1 - 0.6 8.9 12.2 0.67 8.7 12.2 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain GAGA_bind PF06217.12 CDI74680.1 - 1.4 9.2 17.9 1.6 8.9 17.9 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family PAT1 PF09770.9 CDI74680.1 - 1.7 6.8 39.9 1.9 6.6 39.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Afi1 PF07792.12 CDI74680.1 - 2.1 8.8 23.1 0.66 10.5 12.5 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MCM3AP_GANP PF16769.5 CDI74680.1 - 3.3 5.9 22.1 3.6 5.7 22.1 1.0 1 0 0 1 1 1 0 MCM3AP domain of GANP CDC45 PF02724.14 CDI74680.1 - 4 5.6 16.9 5.8 5.1 16.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI74680.1 - 4.3 6.0 28.2 6.1 5.5 28.2 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI74680.1 - 5.3 6.0 24.0 6.7 5.6 24.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CCSAP PF15748.5 CDI74680.1 - 6.2 6.9 25.9 9.2 6.4 25.9 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Endostatin PF06482.11 CDI74680.1 - 7.6 5.9 20.9 12 5.2 20.9 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Hid1 PF12722.7 CDI74680.1 - 7.7 4.5 22.4 9.5 4.2 22.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Hamartin PF04388.12 CDI74680.1 - 8.2 5.0 22.2 10 4.6 22.2 1.1 1 0 0 1 1 1 0 Hamartin protein Sporozoite_P67 PF05642.11 CDI74681.1 - 0.056 11.5 2.2 0.06 11.4 2.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ICA69 PF04629.14 CDI74681.1 - 0.34 11.2 12.3 0.37 11.1 12.3 1.1 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain Pex14_N PF04695.13 CDI74681.1 - 0.37 11.4 21.0 0.47 11.1 21.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ESM4 PF15952.5 CDI74681.1 - 0.48 10.8 17.7 0.55 10.6 17.7 1.2 1 0 0 1 1 1 0 Enhancer of split M4 family Hist_deacetyl PF00850.19 CDI74681.1 - 1.7 8.0 6.4 1.8 8.0 6.4 1.0 1 0 0 1 1 1 0 Histone deacetylase domain NST1 PF13945.6 CDI74681.1 - 3.2 7.8 19.9 3.9 7.6 19.9 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Shadoo PF14999.6 CDI74682.1 - 0.096 12.8 16.8 0.091 12.9 6.1 2.2 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Caldesmon PF02029.15 CDI74682.1 - 0.19 10.4 57.5 0.23 10.2 57.5 1.1 1 0 0 1 1 1 0 Caldesmon GREB1 PF15782.5 CDI74682.1 - 1.1 6.3 61.7 1.5 5.9 61.7 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Asp-B-Hydro_N PF05279.11 CDI74682.1 - 1.6 8.8 45.1 1.9 8.5 45.1 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region HEV_ORF1 PF02444.16 CDI74682.1 - 2.6 8.6 9.9 8.3 7.0 1.5 2.2 2 0 0 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) Hid1 PF12722.7 CDI74682.1 - 3.4 5.7 57.1 4.5 5.3 57.1 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Utp14 PF04615.13 CDI74682.1 - 7.3 5.0 62.7 8.9 4.7 62.7 1.1 1 0 0 1 1 1 0 Utp14 protein RskA PF10099.9 CDI74683.1 - 5.5e-07 30.1 35.1 0.0023 18.2 18.4 4.2 2 2 1 4 4 4 2 Anti-sigma-K factor rskA PAP1 PF08601.10 CDI74683.1 - 0.00075 19.3 3.0 0.00075 19.3 3.0 2.9 2 1 1 3 3 3 1 Transcription factor PAP1 BPD_transp_2 PF02653.16 CDI74683.1 - 0.007 15.6 0.3 2.6 7.2 1.2 2.3 2 0 0 2 2 2 2 Branched-chain amino acid transport system / permease component FlxA PF14282.6 CDI74683.1 - 0.0076 16.2 20.9 0.0076 16.2 20.9 7.7 6 1 1 7 7 7 1 FlxA-like protein SpoIIE PF07228.12 CDI74683.1 - 0.033 14.1 0.1 0.033 14.1 0.1 1.9 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Oxidored_q3 PF00499.20 CDI74683.1 - 0.37 10.5 4.4 0.44 10.3 1.8 2.4 2 1 1 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Sulf_transp PF04143.14 CDI74683.1 - 0.42 10.1 2.7 3.5 7.1 0.3 2.3 2 0 0 2 2 2 0 Sulphur transport WBP-1 PF11669.8 CDI74684.1 - 0.17 12.5 0.2 0.17 12.5 0.2 4.3 1 1 1 2 2 2 0 WW domain-binding protein 1 MarC PF01914.17 CDI74684.1 - 0.24 10.8 0.1 0.24 10.8 0.1 3.2 1 1 1 2 2 2 0 MarC family integral membrane protein Choline_transpo PF04515.12 CDI74684.1 - 1.8 7.7 3.5 0.57 9.3 1.1 1.4 1 1 0 1 1 1 0 Plasma-membrane choline transporter ECM1 PF05782.11 CDI74684.1 - 3.4 6.5 53.0 4.2 6.2 53.0 1.0 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) SOBP PF15279.6 CDI74684.1 - 6.8 7.2 55.0 8.1 7.0 55.0 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4131 PF13567.6 CDI74687.1 - 0.028 14.1 5.3 1.1 8.9 0.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) IF3_N PF05198.16 CDI74687.1 - 0.035 14.4 1.9 7.2 7.0 0.2 2.6 1 1 1 2 2 2 0 Translation initiation factor IF-3, N-terminal domain Xrn1_D3 PF18194.1 CDI74687.1 - 0.22 11.6 0.1 19 5.4 0.0 2.4 1 1 1 2 2 2 0 Exoribonuclease 1 Domain-3 Prefoldin PF02996.17 CDI74688.1 - 5e-17 61.9 6.6 7.5e-17 61.4 6.6 1.3 1 0 0 1 1 1 1 Prefoldin subunit eIF-4B PF06273.11 CDI74688.1 - 0.0019 17.4 0.3 0.0028 16.8 0.3 1.3 1 0 0 1 1 1 1 Plant specific eukaryotic initiation factor 4B TMPIT PF07851.13 CDI74688.1 - 0.62 9.3 7.3 0.47 9.7 0.3 2.0 2 0 0 2 2 2 0 TMPIT-like protein V-SNARE PF05008.15 CDI74688.1 - 2.5 8.5 11.7 3 8.3 2.3 2.4 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF2722 PF10846.8 CDI74690.1 - 2.3e-05 23.6 11.7 2.3e-05 23.6 11.7 3.3 2 1 1 3 3 1 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI74690.1 - 8e-05 23.0 17.5 8e-05 23.0 17.5 6.4 2 1 2 4 4 1 1 Anti-sigma-K factor rskA Otopetrin PF03189.13 CDI74690.1 - 0.00033 19.6 4.7 0.0006 18.8 4.7 1.4 1 0 0 1 1 1 1 Otopetrin PAT1 PF09770.9 CDI74690.1 - 0.0004 18.8 37.1 0.00091 17.6 11.0 2.2 2 0 0 2 2 2 2 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 CDI74690.1 - 0.0029 16.7 17.7 0.042 12.9 6.6 2.1 2 0 0 2 2 2 2 Solute carrier family 12 Dynamin_N PF00350.23 CDI74690.1 - 0.0033 17.5 8.2 0.12 12.4 1.5 2.2 2 0 0 2 2 2 2 Dynamin family PPL5 PF18168.1 CDI74690.1 - 0.0033 16.8 12.1 0.26 10.5 0.6 2.2 2 0 0 2 2 2 2 Prim-pol family 5 Presenilin PF01080.17 CDI74690.1 - 0.0045 15.8 22.3 0.056 12.2 4.4 2.3 2 0 0 2 2 2 2 Presenilin TCP PF03634.13 CDI74690.1 - 0.0048 17.5 20.2 0.055 14.0 5.1 2.6 2 0 0 2 2 2 2 TCP family transcription factor ASD2 PF08687.11 CDI74690.1 - 0.012 15.2 29.4 0.24 11.0 15.9 2.5 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Neur_chan_memb PF02932.16 CDI74690.1 - 0.018 15.1 19.0 0.13 12.3 4.5 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF1943 PF09172.11 CDI74690.1 - 0.047 12.9 14.2 0.18 11.0 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) eIF-3_zeta PF05091.12 CDI74690.1 - 0.049 12.6 26.1 0.063 12.2 4.2 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EIF4E-T PF10477.9 CDI74690.1 - 0.054 12.3 32.7 0.062 12.1 5.0 2.1 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Connexin PF00029.19 CDI74690.1 - 0.12 12.1 20.2 0.065 13.0 2.7 2.2 2 0 0 2 2 2 0 Connexin Suf PF05843.14 CDI74690.1 - 0.17 11.8 31.6 0.099 12.6 9.5 2.6 3 0 0 3 3 2 0 Suppressor of forked protein (Suf) Gti1_Pac2 PF09729.9 CDI74690.1 - 0.17 11.9 18.1 0.078 13.1 0.9 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family UBA_e1_thiolCys PF10585.9 CDI74690.1 - 0.18 11.7 17.5 0.49 10.3 7.0 2.3 2 0 0 2 2 2 0 Ubiquitin-activating enzyme active site OATP PF03137.20 CDI74690.1 - 0.19 10.0 11.3 0.26 9.5 1.2 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family CAF1 PF04857.20 CDI74690.1 - 0.21 10.7 10.8 1.3 8.1 0.2 2.2 2 0 0 2 2 2 0 CAF1 family ribonuclease Lin-8 PF03353.15 CDI74690.1 - 0.26 10.8 29.4 0.29 10.6 3.8 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Peptidase_S49_N PF08496.10 CDI74690.1 - 0.26 11.3 19.9 0.24 11.5 7.4 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal RR_TM4-6 PF06459.12 CDI74690.1 - 0.27 11.0 23.1 0.42 10.4 3.9 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF4746 PF15928.5 CDI74690.1 - 0.28 10.6 16.8 0.45 9.9 2.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) SID-1_RNA_chan PF13965.6 CDI74690.1 - 0.32 9.4 12.3 1.4 7.3 3.7 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 SpoIIP PF07454.11 CDI74690.1 - 0.38 10.2 26.0 0.47 9.9 5.4 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) EPL1 PF10513.9 CDI74690.1 - 0.45 10.9 25.6 0.7 10.3 6.6 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like Fapy_DNA_glyco PF01149.24 CDI74690.1 - 0.66 10.6 3.4 1.9 9.1 3.2 1.8 1 1 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase N-terminal domain AAA_11 PF13086.6 CDI74690.1 - 1.1 9.0 26.4 0.67 9.7 1.8 2.4 2 1 0 2 2 2 0 AAA domain Tim54 PF11711.8 CDI74690.1 - 1.1 8.0 19.2 0.49 9.1 2.0 2.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Hid1 PF12722.7 CDI74690.1 - 1.1 7.3 18.6 0.24 9.5 4.6 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein TssO PF17561.2 CDI74690.1 - 1.2 9.2 27.2 2.7 8.1 14.8 2.2 2 0 0 2 2 2 0 Type VI secretion system, TssO Hamartin PF04388.12 CDI74690.1 - 1.3 7.6 28.6 0.14 10.8 8.8 2.1 2 0 0 2 2 2 0 Hamartin protein PA26 PF04636.13 CDI74690.1 - 1.3 7.8 18.5 2.5 7.0 1.8 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) CLN3 PF02487.17 CDI74690.1 - 1.5 7.8 22.0 1.6 7.7 3.9 2.2 2 0 0 2 2 2 0 CLN3 protein Plasmodium_Vir PF05795.11 CDI74690.1 - 1.5 8.1 8.9 3.4 7.0 1.1 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Folliculin PF11704.8 CDI74690.1 - 1.7 8.5 16.8 4.9 7.0 2.3 2.6 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport GPCR_chapero_1 PF11904.8 CDI74690.1 - 1.9 7.9 11.8 2.3 7.6 0.2 2.2 2 0 0 2 2 2 0 GPCR-chaperone Afi1 PF07792.12 CDI74690.1 - 2.2 8.8 23.3 3.7 8.0 6.6 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FAM60A PF15396.6 CDI74690.1 - 2.3 8.2 18.7 0.51 10.3 1.0 2.3 2 0 0 2 2 2 0 Protein Family FAM60A Pet20 PF08692.10 CDI74690.1 - 2.4 8.9 12.1 2.5 8.8 1.1 2.5 2 0 0 2 2 2 0 Mitochondrial protein Pet20 Serinc PF03348.15 CDI74690.1 - 2.5 6.9 14.1 1.7 7.5 2.6 2.2 2 0 0 2 2 2 0 Serine incorporator (Serinc) ALMT PF11744.8 CDI74690.1 - 2.5 6.8 20.5 3 6.6 8.0 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter EOS1 PF12326.8 CDI74690.1 - 2.6 8.0 13.3 3.2 7.7 1.2 2.3 2 0 0 2 2 2 0 N-glycosylation protein MDM10 PF12519.8 CDI74690.1 - 3.1 6.6 20.9 0.15 10.9 0.8 2.1 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 PIP5K PF01504.18 CDI74690.1 - 3.3 6.9 19.0 4.9 6.3 6.4 2.3 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase RLL PF10036.9 CDI74690.1 - 3.4 7.5 38.5 0.27 11.1 7.9 3.5 2 1 0 2 2 2 0 RNA transcription, translation and transport factor protein FAM176 PF14851.6 CDI74690.1 - 3.9 7.1 17.1 1.7 8.3 3.3 2.6 2 0 0 2 2 2 0 FAM176 family BORG_CEP PF14957.6 CDI74690.1 - 4 8.6 18.3 1.6 9.9 1.4 2.6 2 0 0 2 2 2 0 Cdc42 effector Band_3_cyto PF07565.13 CDI74690.1 - 4 7.2 28.9 3.1 7.5 8.0 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain MCU PF04678.13 CDI74690.1 - 4.3 7.4 26.5 2.3 8.3 2.4 3.0 3 0 0 3 3 3 0 Mitochondrial calcium uniporter HAUS6_N PF14661.6 CDI74690.1 - 4.6 6.8 36.1 4.7 6.7 19.9 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus CSRNP_N PF16019.5 CDI74690.1 - 5.2 6.9 27.9 0.67 9.8 4.8 2.2 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus DUF1512 PF07431.12 CDI74690.1 - 5.3 5.9 6.0 0.93 8.4 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1512) DUF1917 PF08939.10 CDI74690.1 - 5.5 6.8 18.3 0.61 9.9 3.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1917) V_ATPase_I PF01496.19 CDI74690.1 - 5.7 4.7 29.0 2.2 6.1 7.2 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family RRP36 PF06102.12 CDI74690.1 - 5.9 6.8 36.1 2.8 7.9 5.8 2.3 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 LIM_bind PF01803.16 CDI74690.1 - 6.5 6.2 22.4 0.68 9.4 4.0 2.4 2 0 0 2 2 2 0 LIM-domain binding protein TERB2 PF15101.6 CDI74690.1 - 7.8 6.5 37.0 3.3 7.7 11.2 2.6 2 0 0 2 2 2 0 Telomere-associated protein TERB2 CR6_interact PF10147.9 CDI74690.1 - 8.1 6.1 32.3 0.46 10.2 17.3 2.3 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 PepSY_TM_like_2 PF16357.5 CDI74690.1 - 8.2 6.3 19.4 2.3 8.2 1.8 2.6 2 0 0 2 2 2 0 Putative PepSY_TM-like Rtf2 PF04641.12 CDI74690.1 - 9.4 5.5 21.5 6.2 6.1 4.0 2.6 2 0 0 2 2 2 0 Rtf2 RING-finger DUF2828 PF11443.8 CDI74690.1 - 9.5 4.2 25.1 2 6.4 3.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Mucin PF01456.17 CDI74691.1 - 9.5e-06 25.7 8.1 9.5e-06 25.7 8.1 2.3 2 0 0 2 2 2 1 Mucin-like glycoprotein NMDAR2_C PF10565.9 CDI74691.1 - 1.5e-05 24.1 3.9 2.2e-05 23.6 3.9 1.2 1 0 0 1 1 1 1 N-methyl D-aspartate receptor 2B3 C-terminus XRCC4 PF06632.12 CDI74691.1 - 0.0011 17.9 4.0 0.0028 16.6 4.0 1.6 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 Cohesin_HEAT PF12765.7 CDI74691.1 - 0.004 17.4 1.1 0.14 12.5 1.5 2.4 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion MPM1 PF17234.2 CDI74691.1 - 0.066 13.5 3.4 0.13 12.5 3.4 1.5 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 HEAT PF02985.22 CDI74691.1 - 0.66 10.4 4.8 11 6.6 0.4 3.9 3 0 0 3 3 3 0 HEAT repeat Neur_chan_memb PF02932.16 CDI74691.1 - 3.7 7.5 10.5 0.54 10.3 5.7 1.8 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Mcm10 PF09332.11 CDI74691.1 - 5.9 6.2 19.9 6 6.2 2.3 2.2 2 0 0 2 2 2 0 Mcm10 replication factor Spt20 PF12090.8 CDI74692.1 - 0.00058 19.6 12.7 0.00061 19.5 12.7 1.1 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI74692.1 - 0.002 17.1 10.8 0.0023 17.0 10.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Lin-8 PF03353.15 CDI74692.1 - 0.0046 16.6 6.1 0.0048 16.5 6.1 1.0 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist AF-4 PF05110.13 CDI74692.1 - 0.013 13.6 13.9 0.019 13.1 13.9 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Med15 PF09606.10 CDI74692.1 - 0.021 13.6 11.9 0.019 13.7 11.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CIAPIN1 PF05093.13 CDI74692.1 - 0.026 15.0 0.6 0.03 14.8 0.6 1.1 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis TFIIA PF03153.13 CDI74692.1 - 0.065 13.2 13.9 0.069 13.1 13.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit 7tm_2 PF00002.24 CDI74692.1 - 0.093 12.0 0.7 0.1 11.9 0.7 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) RskA PF10099.9 CDI74692.1 - 0.13 12.6 3.5 0.13 12.5 3.5 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA UPF0239 PF06783.11 CDI74692.1 - 0.32 11.2 3.8 0.29 11.3 0.6 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) Ni_hydr_CYTB PF01292.20 CDI74693.1 - 0.0079 15.8 1.0 0.012 15.2 0.2 1.6 1 1 1 2 2 2 1 Prokaryotic cytochrome b561 Scs3p PF10261.9 CDI74693.1 - 0.2 11.2 13.8 0.032 13.7 9.1 2.1 1 1 1 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF3619 PF12279.8 CDI74693.1 - 0.45 10.8 2.8 0.62 10.4 1.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3619) MAPEG PF01124.18 CDI74693.1 - 5.7 6.9 5.7 6.8 6.6 0.0 2.6 2 1 0 2 2 2 0 MAPEG family Cyt_bd_oxida_II PF02322.15 CDI74694.1 - 0.0094 15.4 0.3 0.049 13.0 0.3 2.2 1 1 0 1 1 1 1 Cytochrome bd terminal oxidase subunit II Hamartin PF04388.12 CDI74694.1 - 2.7 6.5 58.7 0.28 9.8 43.2 2.2 2 0 0 2 2 2 0 Hamartin protein Tetraspanin PF00335.20 CDI74694.1 - 2.8 7.6 6.3 45 3.6 6.8 2.5 2 1 0 2 2 2 0 Tetraspanin family Adaptin_binding PF10199.9 CDI74696.1 - 0.0017 19.0 1.8 0.0017 19.0 1.8 5.6 2 2 2 4 4 4 1 Alpha and gamma adaptin binding protein p34 Caldesmon PF02029.15 CDI74696.1 - 0.0083 14.9 114.4 0.0057 15.5 64.8 2.4 2 0 0 2 2 2 2 Caldesmon DUF2722 PF10846.8 CDI74697.1 - 5.4e-06 25.6 6.1 5.4e-06 25.6 6.1 2.7 3 0 0 3 3 3 2 Protein of unknown function (DUF2722) Velvet PF11754.8 CDI74697.1 - 0.55 10.1 10.4 3.6 7.5 8.2 2.2 2 0 0 2 2 2 0 Velvet factor Ndc1_Nup PF09531.10 CDI74697.1 - 1.4 7.5 6.9 3.8 6.1 6.5 1.9 3 0 0 3 3 3 0 Nucleoporin protein Ndc1-Nup DUF719 PF05334.13 CDI74697.1 - 4.1 7.6 10.3 2.4 8.3 7.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF719) MecA PF05389.12 CDI74697.1 - 6.4 6.3 7.2 11 5.6 4.8 2.0 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF2721 PF11026.8 CDI74700.1 - 0.0024 17.7 1.5 0.0027 17.6 0.9 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2721) NUDE_C PF04880.13 CDI74700.1 - 0.023 15.2 6.0 0.029 14.9 6.0 1.1 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Med3 PF11593.8 CDI74700.1 - 0.34 10.0 22.9 0.45 9.6 22.9 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF677 PF05055.12 CDI74700.1 - 0.35 9.7 4.6 0.42 9.4 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF677) CCDC53 PF10152.9 CDI74700.1 - 4.6 7.6 7.5 6.7 7.1 7.5 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex FAM199X PF15814.5 CDI74700.1 - 5.1 6.1 8.3 5.7 5.9 8.3 1.2 1 0 0 1 1 1 0 Protein family FAM199X RskA PF10099.9 CDI74701.1 - 6.5e-05 23.3 18.2 6.5e-05 23.3 18.2 5.5 2 1 2 4 4 2 1 Anti-sigma-K factor rskA Otopetrin PF03189.13 CDI74701.1 - 6.6e-05 21.9 0.0 0.00018 20.5 0.0 1.6 1 1 0 1 1 1 1 Otopetrin DUF2076 PF09849.9 CDI74701.1 - 0.0021 18.2 23.9 0.0021 18.2 23.9 4.3 4 2 0 4 4 2 1 Uncharacterized protein conserved in bacteria (DUF2076) CCDC106 PF15794.5 CDI74701.1 - 0.016 15.0 1.9 0.016 15.0 1.9 3.1 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 106 EOS1 PF12326.8 CDI74701.1 - 0.039 13.9 8.0 0.09 12.7 0.4 3.1 3 0 0 3 3 3 0 N-glycosylation protein MecA PF05389.12 CDI74701.1 - 0.15 11.7 12.4 0.02 14.6 3.3 2.7 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) DUF3807 PF12720.7 CDI74701.1 - 0.19 12.0 23.9 0.055 13.7 9.8 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) TCP PF03634.13 CDI74701.1 - 0.26 11.9 26.0 2 9.0 9.7 3.3 3 0 0 3 3 3 0 TCP family transcription factor Nha1_C PF08619.10 CDI74701.1 - 0.37 9.9 24.0 0.91 8.7 6.4 3.2 3 0 0 3 3 3 0 Alkali metal cation/H+ antiporter Nha1 C terminus Lin-8 PF03353.15 CDI74701.1 - 0.6 9.6 33.4 0.37 10.3 11.1 3.2 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist Tau95_N PF17682.1 CDI74701.1 - 0.68 10.1 9.0 0.37 11.0 4.4 2.6 2 0 0 2 2 2 0 Tau95 Triple barrel domain Thg1C PF14413.6 CDI74701.1 - 0.69 10.1 11.8 4.9 7.3 8.0 2.9 2 0 0 2 2 2 0 Thg1 C terminal domain EPL1 PF10513.9 CDI74701.1 - 0.87 10.0 22.3 0.29 11.5 8.7 3.3 3 0 0 3 3 3 0 Enhancer of polycomb-like Consortin_C PF15281.6 CDI74701.1 - 1.2 9.2 8.6 0.74 9.8 2.6 2.6 2 1 0 2 2 2 0 Consortin C-terminus PcfK PF14058.6 CDI74701.1 - 1.2 9.4 20.7 0.2 12.0 13.8 2.4 2 0 0 2 2 2 0 PcfK-like protein Peroxin-13_N PF04088.13 CDI74701.1 - 1.3 9.3 12.4 0.19 12.0 3.4 3.1 3 0 0 3 3 3 0 Peroxin 13, N-terminal region eIF-3_zeta PF05091.12 CDI74701.1 - 2.6 6.9 23.9 1.6 7.6 16.5 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2052 PF09747.9 CDI74701.1 - 3.9 7.6 18.8 0.15 12.2 6.2 3.2 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) EBP50_C PF09007.11 CDI74701.1 - 4.2 8.4 25.8 0.68 10.9 4.1 3.6 3 0 0 3 3 3 0 EBP50, C-terminal Connexin PF00029.19 CDI74701.1 - 4.6 6.9 16.5 0.15 11.8 7.2 2.7 3 0 0 3 3 3 0 Connexin Orf78 PF06024.12 CDI74701.1 - 5.5 7.3 15.0 1.3 9.4 5.4 3.3 3 0 0 3 3 3 0 Orf78 (ac78) BUD22 PF09073.10 CDI74701.1 - 5.6 6.2 25.1 0.52 9.6 5.7 2.8 3 0 0 3 3 3 0 BUD22 TFB6 PF17110.5 CDI74701.1 - 5.7 6.7 9.2 2.1 8.1 4.5 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Sporozoite_P67 PF05642.11 CDI74701.1 - 6 4.8 9.8 0.22 9.6 0.8 2.3 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Afi1 PF07792.12 CDI74701.1 - 9.9 6.6 19.6 1.2 9.6 8.3 3.2 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking GRA6 PF05084.13 CDI74702.1 - 0.0091 16.0 3.9 0.01 15.8 3.9 1.0 1 0 0 1 1 1 1 Granule antigen protein (GRA6) DcuA_DcuB PF03605.14 CDI74702.1 - 0.04 12.8 7.1 0.049 12.5 7.1 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Neur_chan_memb PF02932.16 CDI74702.1 - 0.082 13.0 5.7 0.086 12.9 5.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region V_ATPase_I PF01496.19 CDI74702.1 - 0.091 10.7 3.8 0.081 10.8 3.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RskA PF10099.9 CDI74702.1 - 0.092 13.0 28.1 0.14 12.5 28.1 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF4820 PF16091.5 CDI74702.1 - 0.098 12.0 7.3 0.12 11.7 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Presenilin PF01080.17 CDI74702.1 - 0.13 11.1 11.6 0.14 10.9 11.6 1.1 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 CDI74702.1 - 0.17 10.2 0.6 0.19 10.1 0.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI74702.1 - 0.26 10.2 3.8 0.32 9.9 3.8 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) eIF-3_zeta PF05091.12 CDI74702.1 - 0.35 9.8 13.5 0.38 9.7 13.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SpoIIP PF07454.11 CDI74702.1 - 0.37 10.2 9.1 0.4 10.1 9.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Peptidase_C58 PF03543.14 CDI74702.1 - 0.45 10.2 15.6 0.52 10.0 15.6 1.1 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen EOS1 PF12326.8 CDI74702.1 - 0.48 10.3 1.9 0.59 10.0 1.9 1.2 1 0 0 1 1 1 0 N-glycosylation protein DUF4175 PF13779.6 CDI74702.1 - 0.56 8.1 30.8 0.71 7.7 30.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TFIIA PF03153.13 CDI74702.1 - 0.66 9.9 38.3 0.74 9.7 38.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 CDI74702.1 - 0.94 8.5 14.0 1.3 8.1 14.0 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF4045 PF13254.6 CDI74702.1 - 0.97 9.0 13.3 1.2 8.8 13.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) FAM60A PF15396.6 CDI74702.1 - 1.3 9.0 8.0 1.5 8.8 8.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DDHD PF02862.17 CDI74702.1 - 1.4 9.0 9.9 1.8 8.7 9.9 1.2 1 0 0 1 1 1 0 DDHD domain PAT1 PF09770.9 CDI74702.1 - 2.1 6.5 24.6 2.5 6.3 24.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RR_TM4-6 PF06459.12 CDI74702.1 - 2.1 8.1 11.4 2.6 7.8 11.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Suf PF05843.14 CDI74702.1 - 2.2 8.2 18.3 2.6 8.0 18.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FAM199X PF15814.5 CDI74702.1 - 2.2 7.2 9.2 2.7 6.9 9.2 1.1 1 0 0 1 1 1 0 Protein family FAM199X Conotoxin PF02950.17 CDI74702.1 - 3.5 8.7 14.3 1.2 10.2 0.3 2.4 2 0 0 2 2 2 0 Conotoxin Pannexin_like PF12534.8 CDI74702.1 - 5.3 6.0 9.1 4.1 6.4 7.7 1.3 1 1 0 1 1 1 0 Pannexin-like TM region of LRRC8 Trp_oprn_chp PF09534.10 CDI74702.1 - 6.3 6.6 21.5 13 5.6 21.5 1.5 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Atrophin-1 PF03154.15 CDI74702.1 - 8 4.6 20.1 9.5 4.4 20.1 1.0 1 0 0 1 1 1 0 Atrophin-1 family PI3K_1B_p101 PF10486.9 CDI74703.1 - 0.006 14.4 22.3 0.0071 14.2 22.3 1.1 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Hid1 PF12722.7 CDI74703.1 - 0.014 13.5 23.1 0.016 13.4 23.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SART-1 PF03343.13 CDI74703.1 - 0.24 9.9 19.9 0.38 9.3 19.9 1.3 1 0 0 1 1 1 0 SART-1 family GREB1 PF15782.5 CDI74703.1 - 0.46 7.6 30.8 0.55 7.3 30.8 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Utp14 PF04615.13 CDI74703.1 - 0.51 8.8 25.2 0.64 8.5 25.2 1.1 1 0 0 1 1 1 0 Utp14 protein PPP4R2 PF09184.11 CDI74703.1 - 0.61 9.6 26.0 0.77 9.3 26.0 1.1 1 0 0 1 1 1 0 PPP4R2 SRP-alpha_N PF04086.13 CDI74703.1 - 1.6 8.6 26.4 2.5 8.0 26.4 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal MAP70 PF07058.11 CDI74703.1 - 1.7 7.3 30.7 2.7 6.6 30.7 1.3 1 0 0 1 1 1 0 Microtubule-associated protein 70 LAP1C PF05609.12 CDI74703.1 - 6.2 5.8 34.6 8.5 5.3 34.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) LMBR1 PF04791.16 CDI74703.1 - 6.8 5.5 13.6 7.3 5.4 13.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Cwf_Cwc_15 PF04889.12 CDI74703.1 - 9.5 5.9 26.0 21 4.8 26.0 1.6 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SPX PF03105.19 CDI74704.1 - 0.0004 20.4 9.2 0.03 14.3 9.2 2.2 1 1 0 1 1 1 1 SPX domain Apt1 PF10351.9 CDI74704.1 - 0.023 13.5 12.7 0.62 8.9 6.3 2.6 2 1 1 3 3 3 0 Golgi-body localisation protein domain Presenilin PF01080.17 CDI74704.1 - 0.032 13.0 12.7 0.054 12.3 4.6 2.4 2 0 0 2 2 2 0 Presenilin SUIM_assoc PF16619.5 CDI74704.1 - 0.047 13.8 0.4 0.047 13.8 0.4 3.3 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF4834 PF16118.5 CDI74704.1 - 0.12 13.3 15.7 4.1 8.4 0.6 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) Velvet PF11754.8 CDI74704.1 - 4 7.3 20.3 4.8 7.1 5.3 2.9 2 2 0 2 2 2 0 Velvet factor CNOT1_CAF1_bind PF16415.5 CDI74706.1 - 1.4e-20 73.7 11.1 3.4e-13 49.5 0.2 2.9 3 0 0 3 3 3 2 CCR4-NOT transcription complex subunit 1 CAF1-binding domain AAA_11 PF13086.6 CDI74706.1 - 0.00031 20.6 18.7 0.0024 17.7 13.8 2.2 2 0 0 2 2 2 1 AAA domain Band_3_cyto PF07565.13 CDI74706.1 - 0.0012 18.7 20.8 0.057 13.2 0.2 2.4 2 0 0 2 2 2 2 Band 3 cytoplasmic domain Activator_LAG-3 PF11498.8 CDI74706.1 - 0.0032 16.5 16.5 0.0032 16.5 16.5 3.2 2 1 1 3 3 1 1 Transcriptional activator LAG-3 DUF913 PF06025.12 CDI74706.1 - 0.0068 15.4 7.2 0.0068 15.4 7.2 2.2 2 0 0 2 2 2 1 Domain of Unknown Function (DUF913) BORG_CEP PF14957.6 CDI74706.1 - 0.0089 17.2 23.9 0.31 12.2 12.3 2.4 2 0 0 2 2 2 2 Cdc42 effector DUF755 PF05501.11 CDI74706.1 - 0.0098 16.2 21.1 0.0098 16.2 21.1 3.3 2 1 1 3 3 1 1 Domain of unknown function (DUF755) CCSAP PF15748.5 CDI74706.1 - 0.016 15.4 16.2 0.016 15.4 16.2 3.4 3 1 1 4 4 1 0 Centriole, cilia and spindle-associated SAGA-Tad1 PF12767.7 CDI74706.1 - 0.02 14.7 19.7 0.48 10.1 0.3 2.2 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit Afi1 PF07792.12 CDI74706.1 - 0.02 15.4 14.5 0.02 15.4 14.5 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Pex14_N PF04695.13 CDI74706.1 - 0.023 15.3 27.6 0.023 15.3 27.6 4.0 3 1 0 3 3 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Macoilin PF09726.9 CDI74706.1 - 0.029 13.0 28.9 0.056 12.0 28.9 1.4 1 0 0 1 1 1 0 Macoilin family V_ATPase_I PF01496.19 CDI74706.1 - 0.04 11.9 27.6 0.014 13.4 19.0 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Neur_chan_memb PF02932.16 CDI74706.1 - 0.049 13.7 27.5 0.038 14.0 14.9 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region GAGA_bind PF06217.12 CDI74706.1 - 0.079 13.2 16.3 0.03 14.6 8.9 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family DUF2052 PF09747.9 CDI74706.1 - 0.083 13.0 31.4 0.28 11.3 21.2 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) CNDH2_C PF16858.5 CDI74706.1 - 0.13 12.1 24.4 0.41 10.5 15.0 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term FAM76 PF16046.5 CDI74706.1 - 0.16 11.3 24.5 0.014 14.8 10.1 2.2 2 0 0 2 2 2 0 FAM76 protein XRCC4 PF06632.12 CDI74706.1 - 0.17 10.7 21.5 0.27 10.1 12.6 2.3 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Lin-8 PF03353.15 CDI74706.1 - 0.23 11.0 42.2 1.1 8.7 22.1 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist CLN3 PF02487.17 CDI74706.1 - 0.29 10.1 22.0 0.18 10.8 14.8 2.4 3 0 0 3 3 2 0 CLN3 protein SRP-alpha_N PF04086.13 CDI74706.1 - 0.3 11.0 38.6 0.072 13.0 5.6 2.8 3 0 0 3 3 3 0 Signal recognition particle, alpha subunit, N-terminal DUF572 PF04502.13 CDI74706.1 - 0.32 10.6 24.5 0.043 13.4 11.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) Tim54 PF11711.8 CDI74706.1 - 0.32 9.7 22.0 0.056 12.2 12.7 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Endostatin PF06482.11 CDI74706.1 - 0.42 10.0 27.2 0.13 11.7 15.3 2.2 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin DUF2370 PF10176.9 CDI74706.1 - 0.43 10.2 11.7 0.064 12.9 5.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) Apt1 PF10351.9 CDI74706.1 - 0.49 9.2 25.0 0.8 8.5 10.2 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain XRN_M PF17846.1 CDI74706.1 - 0.73 8.7 16.6 1.5 7.7 12.1 2.1 2 0 0 2 2 2 0 Xrn1 helical domain Sin_N PF04801.13 CDI74706.1 - 0.77 8.9 42.0 0.24 10.6 0.4 2.3 2 0 0 2 2 2 0 Sin-like protein conserved region CSG2 PF16965.5 CDI74706.1 - 0.78 8.6 13.5 0.035 13.1 6.8 1.8 2 0 0 2 2 2 0 Ceramide synthase regulator AF-4 PF05110.13 CDI74706.1 - 0.78 7.8 49.9 0.61 8.1 19.9 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Isy1 PF06246.12 CDI74706.1 - 0.84 9.2 24.2 1.3 8.5 16.7 2.3 2 0 0 2 2 2 0 Isy1-like splicing family Connexin PF00029.19 CDI74706.1 - 1.1 9.0 18.8 0.5 10.1 12.0 2.2 2 0 0 2 2 2 0 Connexin DUF2828 PF11443.8 CDI74706.1 - 1.1 7.2 22.2 0.14 10.2 14.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) DUF4746 PF15928.5 CDI74706.1 - 1.6 8.1 19.5 0.73 9.2 11.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Serinc PF03348.15 CDI74706.1 - 1.8 7.4 11.9 0.34 9.8 6.5 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) GREB1 PF15782.5 CDI74706.1 - 1.9 5.5 34.8 0.57 7.2 16.1 2.2 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer DUF2151 PF10221.9 CDI74706.1 - 2.1 6.8 19.4 0.028 13.0 9.4 1.9 2 0 0 2 2 2 0 Cell cycle and development regulator TRAP_alpha PF03896.16 CDI74706.1 - 2.3 7.4 14.0 0.31 10.2 8.7 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit PAT1 PF09770.9 CDI74706.1 - 3.7 5.7 55.0 0.1 10.8 32.8 2.3 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 DUF3807 PF12720.7 CDI74706.1 - 3.8 7.7 40.5 0.72 10.1 26.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) FAM60A PF15396.6 CDI74706.1 - 4.2 7.3 27.2 1.8 8.5 17.5 2.2 2 0 0 2 2 2 0 Protein Family FAM60A PIP5K PF01504.18 CDI74706.1 - 4.3 6.5 21.2 0.28 10.4 12.1 2.3 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Ctr PF04145.15 CDI74706.1 - 4.7 7.8 21.0 12 6.5 13.5 2.7 2 0 0 2 2 2 0 Ctr copper transporter family HCO3_cotransp PF00955.21 CDI74706.1 - 4.9 5.9 11.3 0.83 8.4 6.2 1.9 2 0 0 2 2 2 0 HCO3- transporter family Presenilin PF01080.17 CDI74706.1 - 5 5.8 40.9 0.22 10.2 23.8 2.2 2 0 0 2 2 2 0 Presenilin SID-1_RNA_chan PF13965.6 CDI74706.1 - 5 5.4 11.5 0.33 9.3 6.2 1.6 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 CDC45 PF02724.14 CDI74706.1 - 5 5.3 25.6 0.17 10.2 16.2 2.1 2 0 0 2 2 2 0 CDC45-like protein Slu7 PF11708.8 CDI74706.1 - 5.4 6.7 32.3 3.1 7.5 1.5 2.4 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor ERO1 PF04137.15 CDI74706.1 - 5.4 6.1 20.3 0.053 12.7 9.3 2.1 2 0 0 2 2 2 0 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) SLC12 PF03522.15 CDI74706.1 - 5.9 5.8 31.8 0.46 9.4 18.7 2.1 2 0 0 2 2 2 0 Solute carrier family 12 RR_TM4-6 PF06459.12 CDI74706.1 - 6.7 6.4 33.1 0.96 9.2 22.1 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CAF1 PF04857.20 CDI74706.1 - 7.5 5.6 16.9 34 3.5 15.1 2.1 2 0 0 2 2 2 0 CAF1 family ribonuclease DUF3295 PF11702.8 CDI74706.1 - 7.6 5.8 38.5 7.9 5.7 19.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) Hid1 PF12722.7 CDI74706.1 - 7.9 4.5 31.6 0.036 12.2 12.6 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein NARP1 PF12569.8 CDI74706.1 - 9.8 5.0 25.4 0.52 9.2 15.9 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 RVP_2 PF08284.11 CDI74708.1 - 0.023 14.4 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 Retroviral aspartyl protease FpoO PF10621.9 CDI74708.1 - 0.18 12.2 0.2 0.58 10.5 0.1 1.8 2 0 0 2 2 2 0 F420H2 dehydrogenase subunit FpoO DUF775 PF05603.12 CDI74708.1 - 0.19 11.2 0.0 0.26 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) AUX_IAA PF02309.16 CDI74710.1 - 0.035 14.0 0.1 0.041 13.7 0.1 1.1 1 0 0 1 1 1 0 AUX/IAA family fn3 PF00041.21 CDI74710.1 - 0.061 13.7 0.0 0.081 13.3 0.0 1.2 1 0 0 1 1 1 0 Fibronectin type III domain Dynamin_M PF01031.20 CDI74711.1 - 7.6e-71 238.6 1.0 1.2e-69 234.7 0.0 2.8 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 CDI74711.1 - 5.4e-37 127.4 0.0 1.5e-36 126.0 0.0 1.8 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 CDI74711.1 - 2.4e-22 78.9 0.1 8.3e-22 77.2 0.1 2.0 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CDI74711.1 - 0.0021 18.1 0.0 0.0071 16.4 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF4726 PF15855.5 CDI74711.1 - 0.015 15.5 1.3 0.015 15.5 1.3 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4726) MPM1 PF17234.2 CDI74711.1 - 0.035 14.4 0.4 0.076 13.3 0.4 1.5 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 SipA PF09052.10 CDI74711.1 - 0.038 13.6 0.3 1.3 8.6 0.0 2.6 2 0 0 2 2 2 0 SipA N-terminal domain PSY3 PF16836.5 CDI74712.1 - 0.16 11.4 2.1 0.44 10.0 2.1 1.7 1 0 0 1 1 1 0 Shu complex component Psy3, DNA-binding description EF_TS PF00889.19 CDI74713.1 - 2.3e-29 102.5 0.2 2e-28 99.4 0.1 2.1 1 1 1 2 2 2 1 Elongation factor TS SMAP PF15477.6 CDI74713.1 - 0.022 15.7 0.1 0.11 13.5 0.1 2.1 2 0 0 2 2 2 0 Small acidic protein family PS_Dcarbxylase PF02666.15 CDI74714.1 - 1.5e-06 27.9 0.0 2.7e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase RskA PF10099.9 CDI74715.1 - 0.00019 21.8 2.9 0.00019 21.8 2.9 7.0 2 2 3 5 5 5 1 Anti-sigma-K factor rskA SID-1_RNA_chan PF13965.6 CDI74715.1 - 0.14 10.5 9.3 0.37 9.2 3.6 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 EPL1 PF10513.9 CDI74715.1 - 1.6 9.1 43.2 0.26 11.7 9.2 4.0 4 0 0 4 4 4 0 Enhancer of polycomb-like SpoIIP PF07454.11 CDI74715.1 - 2.3 7.6 35.6 0.017 14.6 11.8 3.0 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) ubiquitin PF00240.23 CDI74716.1 - 6.9e-13 48.2 0.2 6.9e-13 48.2 0.2 1.9 1 1 1 2 2 1 1 Ubiquitin family DUF2407 PF10302.9 CDI74716.1 - 0.00015 22.3 5.0 0.00015 22.3 5.0 1.4 2 0 0 2 2 1 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 CDI74716.1 - 0.00023 20.9 0.1 0.00023 20.9 0.1 1.9 1 1 1 2 2 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF1645 PF07816.11 CDI74716.1 - 0.00077 20.1 9.2 0.00091 19.9 9.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1645) DUF2722 PF10846.8 CDI74716.1 - 0.0012 17.9 19.9 0.0017 17.4 19.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Lin-8 PF03353.15 CDI74716.1 - 0.0087 15.7 11.4 0.0095 15.5 11.4 1.1 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist Ubiquitin_2 PF14560.6 CDI74716.1 - 0.0089 16.5 1.6 0.025 15.0 1.6 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Med15 PF09606.10 CDI74716.1 - 0.011 14.5 21.0 0.012 14.4 21.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CIAPIN1 PF05093.13 CDI74716.1 - 0.015 15.8 4.4 0.027 15.0 4.4 1.6 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis TFIIA PF03153.13 CDI74716.1 - 0.018 15.0 24.6 0.021 14.8 24.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CDI74716.1 - 0.02 12.1 11.8 0.02 12.1 11.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 CDI74716.1 - 0.025 13.2 10.1 0.03 12.9 10.1 1.1 1 0 0 1 1 1 0 Macoilin family AF-4 PF05110.13 CDI74716.1 - 0.03 12.4 15.8 0.041 12.0 15.8 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein MAP65_ASE1 PF03999.12 CDI74716.1 - 0.033 12.9 9.6 0.036 12.8 9.6 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) BORG_CEP PF14957.6 CDI74716.1 - 0.051 14.7 7.5 0.063 14.4 7.5 1.2 1 0 0 1 1 1 0 Cdc42 effector Roughex PF06020.11 CDI74716.1 - 0.053 12.6 10.2 0.063 12.4 10.2 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF3801 PF12687.7 CDI74716.1 - 0.064 13.3 7.9 0.078 13.0 7.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) BAT2_N PF07001.11 CDI74716.1 - 0.087 13.3 15.0 0.11 12.9 15.0 1.2 1 0 0 1 1 1 0 BAT2 N-terminus SPX PF03105.19 CDI74716.1 - 0.1 12.5 12.9 0.13 12.2 12.9 1.0 1 0 0 1 1 1 0 SPX domain eIF-3_zeta PF05091.12 CDI74716.1 - 0.11 11.5 8.3 0.11 11.5 8.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EPL1 PF10513.9 CDI74716.1 - 0.12 12.7 9.1 0.19 12.1 9.1 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like Plasmodium_Vir PF05795.11 CDI74716.1 - 0.14 11.5 5.0 0.15 11.4 5.0 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein EIIBC-GUT_N PF03612.14 CDI74716.1 - 0.19 11.5 4.4 0.3 10.8 4.4 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Apt1 PF10351.9 CDI74716.1 - 0.21 10.4 11.5 0.23 10.3 11.5 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4407 PF14362.6 CDI74716.1 - 0.26 10.6 6.9 0.32 10.3 6.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDK2AP PF09806.9 CDI74716.1 - 0.39 10.7 14.0 0.58 10.2 14.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Peptidase_S64 PF08192.11 CDI74716.1 - 0.46 8.9 11.3 0.51 8.8 11.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF3807 PF12720.7 CDI74716.1 - 0.5 10.6 14.1 0.62 10.3 14.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Presenilin PF01080.17 CDI74716.1 - 0.55 8.9 12.0 0.64 8.7 12.0 1.1 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 CDI74716.1 - 0.66 8.6 10.4 0.77 8.4 10.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup V_ATPase_I PF01496.19 CDI74716.1 - 0.8 7.6 5.9 0.76 7.6 5.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SLC12 PF03522.15 CDI74716.1 - 0.82 8.6 8.4 0.86 8.6 8.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI74716.1 - 0.97 7.6 14.7 0.95 7.7 14.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ALMT PF11744.8 CDI74716.1 - 1.1 8.0 5.9 1.2 7.9 5.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter RAP1 PF07218.11 CDI74716.1 - 4.1 5.5 8.3 5 5.3 8.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF3408 PF11888.8 CDI74716.1 - 4.4 7.4 11.6 0.33 11.1 7.1 1.4 2 0 0 2 2 1 0 Protein of unknown function (DUF3408) BRF1 PF07741.13 CDI74716.1 - 8.1 6.9 10.8 9.9 6.6 10.6 1.4 1 1 0 1 1 1 0 Brf1-like TBP-binding domain CPSF100_C PF13299.6 CDI74716.1 - 9.6 6.4 13.1 16 5.7 13.1 1.6 1 1 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Caskin1-CID PF16600.5 CDI74717.1 - 0.085 13.4 0.3 0.085 13.4 0.3 2.8 2 0 0 2 2 2 0 Caskin1 CASK-interaction domain Spt20 PF12090.8 CDI74717.1 - 0.49 10.0 9.7 0.97 9.0 9.7 1.5 1 0 0 1 1 1 0 Spt20 family ATAD4 PF15321.6 CDI74718.1 - 0.11 13.8 3.5 0.27 12.6 3.5 1.6 1 1 0 1 1 1 0 ATPase family AAA domain containing 4 DUF4799 PF16056.5 CDI74718.1 - 0.15 11.2 12.8 0.19 10.8 12.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4799) PGA2 PF07543.12 CDI74718.1 - 0.5 10.3 12.9 0.8 9.7 12.7 1.4 1 1 0 1 1 1 0 Protein trafficking PGA2 Presenilin PF01080.17 CDI74718.1 - 1.5 7.5 9.8 1.6 7.4 9.8 1.1 1 0 0 1 1 1 0 Presenilin DUF5349 PF17298.2 CDI74718.1 - 1.7 8.4 9.8 0.17 11.6 3.9 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5349) Band_3_cyto PF07565.13 CDI74718.1 - 3.7 7.3 10.6 10 5.8 10.6 1.7 1 1 0 1 1 1 0 Band 3 cytoplasmic domain Baculo_PP31 PF05311.11 CDI74718.1 - 4.5 6.7 7.4 1.9 7.9 1.5 2.0 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Pex26 PF07163.12 CDI74718.1 - 7.3 5.8 8.4 1 8.6 3.0 1.9 2 0 0 2 2 2 0 Pex26 protein Pkinase PF00069.25 CDI74719.1 - 5.3e-05 22.7 0.0 0.00018 21.0 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain DUF1365 PF07103.11 CDI74719.1 - 0.1 12.2 0.7 3.5 7.2 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1365) ABC1 PF03109.16 CDI74720.1 - 5.6e-05 23.3 2.7 8.8e-05 22.7 2.7 1.4 1 1 0 1 1 1 1 ABC1 family RskA PF10099.9 CDI74720.1 - 0.0001 22.6 9.9 0.00015 22.1 9.9 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI74720.1 - 0.00041 20.5 23.9 0.00042 20.4 23.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RLL PF10036.9 CDI74720.1 - 0.0011 18.8 10.7 0.0016 18.3 10.7 1.2 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein DDHD PF02862.17 CDI74720.1 - 0.0021 18.3 5.7 0.0022 18.2 5.7 1.1 1 0 0 1 1 1 1 DDHD domain Coilin_N PF15862.5 CDI74720.1 - 0.0024 17.7 12.6 0.0035 17.1 12.6 1.2 1 0 0 1 1 1 1 Coilin N-terminus BAF1_ABF1 PF04684.13 CDI74720.1 - 0.0026 16.9 5.2 0.0026 16.9 5.2 1.0 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor CTU2 PF10288.9 CDI74720.1 - 0.004 17.4 11.2 0.0045 17.2 11.2 1.2 1 0 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 V_ATPase_I PF01496.19 CDI74720.1 - 0.0048 14.9 4.7 0.0045 15.0 4.7 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family TRAP_alpha PF03896.16 CDI74720.1 - 0.0076 15.5 2.4 0.0096 15.2 2.4 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Med15 PF09606.10 CDI74720.1 - 0.0081 14.9 22.2 0.0085 14.8 22.2 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal SpoIIP PF07454.11 CDI74720.1 - 0.0088 15.5 8.5 0.0095 15.4 8.5 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Suf PF05843.14 CDI74720.1 - 0.01 15.8 11.9 0.012 15.6 11.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF5308 PF17233.2 CDI74720.1 - 0.013 15.8 6.8 0.014 15.6 6.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5308) CPSF100_C PF13299.6 CDI74720.1 - 0.014 15.6 7.2 0.016 15.4 7.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SelP_N PF04592.14 CDI74720.1 - 0.017 14.5 11.1 0.024 14.0 11.1 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region FAM101 PF15068.6 CDI74720.1 - 0.018 15.0 1.5 0.023 14.7 1.5 1.1 1 0 0 1 1 1 0 FAM101 family Velvet PF11754.8 CDI74720.1 - 0.019 14.9 6.8 0.02 14.9 6.8 1.1 1 0 0 1 1 1 0 Velvet factor eIF_4EBP PF05456.11 CDI74720.1 - 0.023 14.6 6.0 0.033 14.1 6.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) LPP20 PF02169.16 CDI74720.1 - 0.024 15.0 12.6 0.033 14.5 12.6 1.2 1 0 0 1 1 1 0 LPP20 lipoprotein DUF2828 PF11443.8 CDI74720.1 - 0.026 12.6 6.4 0.027 12.6 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MecA PF05389.12 CDI74720.1 - 0.029 14.0 4.8 0.029 14.0 4.8 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Connexin PF00029.19 CDI74720.1 - 0.03 14.1 4.8 0.034 13.9 4.8 1.1 1 0 0 1 1 1 0 Connexin FAM60A PF15396.6 CDI74720.1 - 0.03 14.3 7.9 0.037 14.0 7.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A CLN3 PF02487.17 CDI74720.1 - 0.03 13.4 3.7 0.034 13.2 3.7 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4820 PF16091.5 CDI74720.1 - 0.031 13.6 9.7 0.036 13.4 9.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) OATP PF03137.20 CDI74720.1 - 0.032 12.5 2.1 0.036 12.3 2.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Peroxin-13_N PF04088.13 CDI74720.1 - 0.033 14.5 2.2 0.041 14.2 2.2 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Mlh1_C PF16413.5 CDI74720.1 - 0.033 13.6 7.2 0.037 13.4 7.2 1.1 1 0 0 1 1 1 0 DNA mismatch repair protein Mlh1 C-terminus Orf78 PF06024.12 CDI74720.1 - 0.036 14.4 2.8 0.05 13.9 2.8 1.3 1 0 0 1 1 1 0 Orf78 (ac78) FYDLN_acid PF09538.10 CDI74720.1 - 0.036 14.7 7.6 0.036 14.7 7.6 1.5 2 0 0 2 2 1 0 Protein of unknown function (FYDLN_acid) CbiD PF01888.17 CDI74720.1 - 0.038 13.3 2.1 0.054 12.8 2.1 1.3 1 0 0 1 1 1 0 CbiD EOS1 PF12326.8 CDI74720.1 - 0.039 13.9 2.2 0.041 13.8 2.2 1.1 1 0 0 1 1 1 0 N-glycosylation protein PAT1 PF09770.9 CDI74720.1 - 0.043 12.1 16.2 0.044 12.1 16.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RR_TM4-6 PF06459.12 CDI74720.1 - 0.046 13.6 9.7 0.05 13.4 9.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TERB2 PF15101.6 CDI74720.1 - 0.054 13.5 13.4 0.062 13.4 13.4 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 FAM199X PF15814.5 CDI74720.1 - 0.062 12.3 4.9 0.071 12.2 4.9 1.1 1 0 0 1 1 1 0 Protein family FAM199X DUF913 PF06025.12 CDI74720.1 - 0.066 12.2 6.6 0.075 12.0 6.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) GNT-I PF03071.15 CDI74720.1 - 0.083 11.6 5.1 0.096 11.4 5.1 1.1 1 0 0 1 1 1 0 GNT-I family DUF2072 PF09845.9 CDI74720.1 - 0.083 13.1 8.0 0.14 12.4 8.0 1.4 1 0 0 1 1 1 0 Zn-ribbon containing protein Serinc PF03348.15 CDI74720.1 - 0.087 11.7 5.5 0.099 11.5 5.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) AAA_23 PF13476.6 CDI74720.1 - 0.088 13.3 11.7 0.097 13.2 11.7 1.1 1 0 0 1 1 1 0 AAA domain DUF935 PF06074.12 CDI74720.1 - 0.092 11.5 10.3 0.098 11.4 10.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF935) GvpL_GvpF PF06386.11 CDI74720.1 - 0.095 12.6 9.0 0.11 12.4 9.0 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Spem1 PF15670.5 CDI74720.1 - 0.096 12.3 10.7 0.11 12.0 10.7 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 DUF2722 PF10846.8 CDI74720.1 - 0.099 11.6 28.0 0.13 11.2 28.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CobT PF06213.12 CDI74720.1 - 0.1 12.0 16.8 0.13 11.6 16.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 CDI74720.1 - 0.1 11.3 12.4 0.11 11.3 12.4 1.1 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 CDI74720.1 - 0.11 11.5 13.2 0.12 11.4 13.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SprA-related PF12118.8 CDI74720.1 - 0.12 11.5 25.3 0.13 11.3 25.3 1.1 1 0 0 1 1 1 0 SprA-related family Ndc1_Nup PF09531.10 CDI74720.1 - 0.13 10.9 6.8 0.14 10.9 6.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FHIPEP PF00771.20 CDI74720.1 - 0.14 10.6 7.5 0.18 10.2 7.5 1.1 1 0 0 1 1 1 0 FHIPEP family MMR1 PF08505.10 CDI74720.1 - 0.16 12.3 10.9 0.16 12.2 10.9 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SLC12 PF03522.15 CDI74720.1 - 0.17 10.9 8.0 0.16 11.0 8.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 NPR3 PF03666.13 CDI74720.1 - 0.17 10.7 7.7 0.2 10.4 7.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PIP5K PF01504.18 CDI74720.1 - 0.17 11.1 5.8 0.18 11.0 5.8 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2126 PF09899.9 CDI74720.1 - 0.18 9.9 5.5 0.17 9.9 5.5 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Band_3_cyto PF07565.13 CDI74720.1 - 0.18 11.6 10.2 0.22 11.3 10.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4407 PF14362.6 CDI74720.1 - 0.18 11.1 16.4 0.2 11.0 16.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HNOBA PF07701.14 CDI74720.1 - 0.19 11.2 7.2 0.24 10.8 7.2 1.2 1 0 0 1 1 1 0 Heme NO binding associated Baculo_PP31 PF05311.11 CDI74720.1 - 0.23 10.9 10.1 0.26 10.7 10.1 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Sec62 PF03839.16 CDI74720.1 - 0.25 10.8 5.2 0.29 10.6 5.2 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Paf1 PF03985.13 CDI74720.1 - 0.26 10.3 14.2 0.28 10.1 14.2 1.1 1 0 0 1 1 1 0 Paf1 DUF4834 PF16118.5 CDI74720.1 - 0.26 12.2 11.9 0.44 11.5 11.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 CDI74720.1 - 0.27 10.9 5.6 0.38 10.4 5.6 1.3 1 0 0 1 1 1 0 FAM176 family Rxt3 PF08642.10 CDI74720.1 - 0.28 12.0 3.6 0.4 11.5 3.6 1.4 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 ALMT PF11744.8 CDI74720.1 - 0.3 9.9 5.1 0.29 9.9 5.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF5349 PF17298.2 CDI74720.1 - 0.31 10.8 12.0 0.35 10.6 12.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5349) EIIBC-GUT_N PF03612.14 CDI74720.1 - 0.33 10.7 10.7 0.43 10.3 10.7 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus PepSY_TM PF03929.16 CDI74720.1 - 0.34 10.5 4.6 0.46 10.1 4.6 1.2 1 0 0 1 1 1 0 PepSY-associated TM region THOC2_N PF16134.5 CDI74720.1 - 0.34 9.5 8.9 0.41 9.2 8.9 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Ctr PF04145.15 CDI74720.1 - 0.35 11.5 3.5 0.39 11.3 3.5 1.2 1 0 0 1 1 1 0 Ctr copper transporter family R_equi_Vir PF05526.11 CDI74720.1 - 0.36 10.7 4.3 0.43 10.4 4.3 1.2 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein HA2 PF04408.23 CDI74720.1 - 0.39 11.0 6.3 0.58 10.5 6.3 1.3 1 0 0 1 1 1 0 Helicase associated domain (HA2) EPL1 PF10513.9 CDI74720.1 - 0.4 11.0 10.9 0.54 10.6 10.9 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Neur_chan_memb PF02932.16 CDI74720.1 - 0.41 10.7 8.8 0.47 10.5 8.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Tuberin PF03542.16 CDI74720.1 - 0.46 9.5 4.9 0.53 9.3 4.9 1.1 1 0 0 1 1 1 0 Tuberin Gti1_Pac2 PF09729.9 CDI74720.1 - 0.46 10.5 7.5 0.56 10.3 7.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Folate_carrier PF01770.18 CDI74720.1 - 0.57 8.8 5.1 0.61 8.8 5.1 1.1 1 0 0 1 1 1 0 Reduced folate carrier SPT16 PF08644.11 CDI74720.1 - 0.58 10.3 7.6 0.8 9.9 7.6 1.2 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) MAJIN PF15077.6 CDI74720.1 - 0.63 9.8 6.5 0.69 9.7 6.5 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Ureide_permease PF07168.11 CDI74720.1 - 0.66 8.7 3.8 0.78 8.4 3.8 1.1 1 0 0 1 1 1 0 Ureide permease DUF1980 PF09323.10 CDI74720.1 - 0.66 9.9 7.7 0.83 9.5 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Tim54 PF11711.8 CDI74720.1 - 0.73 8.6 10.7 0.94 8.2 10.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CSG2 PF16965.5 CDI74720.1 - 0.75 8.7 4.6 0.86 8.5 4.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator ArAE_2_N PF10337.9 CDI74720.1 - 0.84 8.6 12.0 1.1 8.2 12.0 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal ABC2_membrane_2 PF12679.7 CDI74720.1 - 0.89 8.8 3.6 0.95 8.7 3.6 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Kei1 PF08552.11 CDI74720.1 - 1.1 9.1 9.2 1.5 8.7 9.2 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 5_nucleotid PF05761.14 CDI74720.1 - 1.1 8.1 7.0 1.4 7.8 7.0 1.1 1 0 0 1 1 1 0 5' nucleotidase family Zip PF02535.22 CDI74720.1 - 1.2 8.3 5.8 1.3 8.2 5.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3408 PF11888.8 CDI74720.1 - 1.2 9.3 13.1 1.9 8.7 13.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Cas1_AcylT PF07779.12 CDI74720.1 - 1.3 7.9 8.0 1.5 7.7 8.0 1.1 1 0 0 1 1 1 0 10 TM Acyl Transferase domain found in Cas1p AIF_C PF14721.6 CDI74720.1 - 1.4 9.3 12.4 2 8.8 12.4 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term PPL5 PF18168.1 CDI74720.1 - 1.4 8.1 8.8 1.9 7.7 8.8 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DcuA_DcuB PF03605.14 CDI74720.1 - 1.7 7.5 3.5 2 7.2 3.5 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter HemX PF04375.14 CDI74720.1 - 1.9 7.7 24.8 2.4 7.4 24.8 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase ATAD4 PF15321.6 CDI74720.1 - 1.9 9.9 8.3 3.4 9.1 8.3 1.4 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 Renin_r PF07850.14 CDI74720.1 - 1.9 9.1 3.4 3.3 8.4 3.4 1.4 1 0 0 1 1 1 0 Renin receptor-like protein Hid1 PF12722.7 CDI74720.1 - 2 6.4 10.8 2 6.4 10.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RICTOR_N PF14664.6 CDI74720.1 - 2 7.3 4.7 2.5 7.0 4.7 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term MDM31_MDM32 PF08118.11 CDI74720.1 - 2.1 6.9 7.9 2.5 6.7 7.9 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins GREB1 PF15782.5 CDI74720.1 - 2.4 5.2 13.6 2.5 5.1 13.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFB6 PF17110.5 CDI74720.1 - 2.5 7.8 9.3 3.6 7.3 9.3 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH ORC_WH_C PF18137.1 CDI74720.1 - 2.9 8.0 12.0 4.6 7.3 12.0 1.4 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal MDM10 PF12519.8 CDI74720.1 - 3.1 6.6 9.0 3.9 6.2 9.0 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Glt_symporter PF03616.14 CDI74720.1 - 3.2 6.4 4.5 4.1 6.0 4.5 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter DUF3464 PF11947.8 CDI74720.1 - 3.5 7.4 12.3 5 6.9 12.3 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 TMEM51 PF15345.6 CDI74720.1 - 3.5 7.4 12.4 5.1 6.9 12.4 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4770 PF15994.5 CDI74720.1 - 3.6 7.8 14.2 2 8.6 12.5 1.4 2 0 0 2 2 1 0 Domain of unknown function (DUF4770) HCO3_cotransp PF00955.21 CDI74720.1 - 5 5.8 5.6 5.2 5.8 5.6 1.0 1 0 0 1 1 1 0 HCO3- transporter family DUF4175 PF13779.6 CDI74720.1 - 5.1 4.9 29.8 6.3 4.6 29.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PigN PF04987.14 CDI74720.1 - 5.2 5.8 6.2 6.1 5.6 6.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Spt20 PF12090.8 CDI74720.1 - 5.4 6.5 40.2 7.9 6.0 40.2 1.2 1 0 0 1 1 1 0 Spt20 family Cellulose_synt PF03552.14 CDI74720.1 - 5.5 5.4 6.3 6.1 5.2 6.3 1.1 1 0 0 1 1 1 0 Cellulose synthase EMC3_TMCO1 PF01956.16 CDI74720.1 - 5.9 6.6 10.3 7.7 6.2 10.3 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like G0-G1_switch_2 PF15103.6 CDI74720.1 - 7 7.1 11.4 13 6.3 11.4 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 DUF3537 PF12056.8 CDI74720.1 - 7 5.4 8.7 8.7 5.0 8.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) Borrelia_P83 PF05262.11 CDI74720.1 - 7.3 5.0 14.1 7.3 5.0 14.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Androgen_recep PF02166.16 CDI74720.1 - 7.7 5.2 34.9 11 4.8 34.9 1.2 1 0 0 1 1 1 0 Androgen receptor Plasmodium_Vir PF05795.11 CDI74720.1 - 8.9 5.6 12.2 12 5.2 12.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein V-ATPase_H_N PF03224.14 CDI74722.1 - 0.1 11.9 0.3 0.53 9.5 0.1 1.9 2 0 0 2 2 2 0 V-ATPase subunit H RskA PF10099.9 CDI74723.1 - 2.4e-05 24.7 7.0 2.4e-05 24.7 7.0 2.2 1 1 1 2 2 2 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI74723.1 - 0.42 10.2 32.4 0.3 10.6 22.3 2.0 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein CNDH2_C PF16858.5 CDI74724.1 - 2.5e-08 34.1 4.2 2.5e-08 34.1 4.2 5.5 3 1 1 4 4 4 2 Condensin II complex subunit CAP-H2 or CNDH2, C-term SUIM_assoc PF16619.5 CDI74724.1 - 0.0012 18.9 1.6 0.0012 18.9 1.6 12.6 6 3 1 7 7 7 2 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI74724.1 - 0.0037 16.9 7.5 0.0037 16.9 7.5 8.2 4 2 3 7 7 7 2 Spt20 family DUF1645 PF07816.11 CDI74724.1 - 0.0086 16.7 2.8 0.0086 16.7 2.8 8.5 5 2 2 7 7 7 3 Protein of unknown function (DUF1645) FAM104 PF15434.6 CDI74724.1 - 0.02 15.4 0.1 0.02 15.4 0.1 8.6 5 2 2 8 8 8 0 Family 104 Spt20 PF12090.8 CDI74725.1 - 0.0076 15.9 9.6 0.0096 15.6 9.6 1.1 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI74725.1 - 0.21 10.5 9.3 0.27 10.1 9.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DSPc PF00782.20 CDI74726.1 - 0.00071 19.4 0.1 0.00071 19.4 0.1 2.7 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain RskA PF10099.9 CDI74726.1 - 0.0013 19.0 8.6 0.0013 19.0 8.6 5.0 1 1 2 3 3 3 1 Anti-sigma-K factor rskA Y_phosphatase3 PF13350.6 CDI74726.1 - 0.002 18.1 0.9 0.002 18.1 0.9 2.9 2 2 0 2 2 2 1 Tyrosine phosphatase family CNDH2_C PF16858.5 CDI74726.1 - 2 8.2 39.5 0.37 10.6 20.3 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term K_channel_TID PF07941.11 CDI74728.1 - 0.036 14.5 9.4 0.036 14.5 9.4 9.2 6 2 2 8 8 8 0 Potassium channel Kv1.4 tandem inactivation domain SUIM_assoc PF16619.5 CDI74729.1 - 0.024 14.7 4.4 0.024 14.7 4.4 5.5 5 1 0 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 Utp14 PF04615.13 CDI74729.1 - 0.17 10.4 19.1 0.23 10.0 19.1 1.1 1 0 0 1 1 1 0 Utp14 protein RskA PF10099.9 CDI74729.1 - 0.5 10.6 14.8 0.58 10.4 8.8 2.5 1 1 1 2 2 2 0 Anti-sigma-K factor rskA AF-4 PF05110.13 CDI74729.1 - 8.2 4.4 46.5 13 3.7 46.5 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Hamartin PF04388.12 CDI74729.1 - 9.4 4.8 33.6 11 4.5 33.6 1.2 1 0 0 1 1 1 0 Hamartin protein DUF4401 PF14351.6 CDI74730.1 - 0.0074 15.6 1.4 0.0074 15.6 1.4 2.9 3 0 0 3 3 3 2 Domain of unknown function (DUF4401) DUF4179 PF13786.6 CDI74730.1 - 0.075 13.5 0.5 0.075 13.5 0.5 5.6 5 2 1 6 6 6 0 Domain of unknown function (DUF4179) Utp14 PF04615.13 CDI74731.1 - 4.7 5.7 61.0 6.8 5.1 61.0 1.2 1 0 0 1 1 1 0 Utp14 protein SARAF PF06682.12 CDI74732.1 - 0.00027 20.7 0.3 0.00027 20.7 0.3 2.1 2 1 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis DivIC PF04977.15 CDI74732.1 - 0.00042 20.0 1.5 0.00042 20.0 1.5 2.7 3 0 0 3 3 3 1 Septum formation initiator SLX9 PF15341.6 CDI74732.1 - 0.0093 16.4 9.2 0.013 15.9 9.2 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 Rtf2 PF04641.12 CDI74732.1 - 0.22 10.9 8.2 0.29 10.5 8.2 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Spt20 PF12090.8 CDI74732.1 - 0.24 11.0 14.2 0.3 10.6 14.2 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI74732.1 - 0.43 10.5 16.9 0.48 10.4 16.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Atg14 PF10186.9 CDI74732.1 - 0.43 9.6 13.4 0.66 9.0 13.4 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.14 CDI74732.1 - 0.49 10.7 17.8 0.69 10.3 17.8 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3810 PF12725.7 CDI74732.1 - 3.1 7.0 20.5 10 5.4 20.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) YabA PF06156.13 CDI74732.1 - 5.3 7.7 12.0 10 6.8 12.0 1.4 1 1 0 1 1 1 0 Initiation control protein YabA PAP2 PF01569.21 CDI74734.1 - 0.083 12.7 2.5 0.12 12.2 1.9 1.7 1 1 0 1 1 1 0 PAP2 superfamily Pex14_N PF04695.13 CDI74734.1 - 5.8 7.6 18.3 39 4.9 0.1 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 CDI74735.1 - 0.0004 20.1 9.4 0.0004 20.1 9.4 1.2 1 0 0 1 1 1 1 Spt20 family DUF775 PF05603.12 CDI74736.1 - 0.011 15.2 11.4 0.012 15.2 11.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) PH_4 PF15404.6 CDI74736.1 - 0.026 14.3 6.6 0.027 14.3 6.6 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain PhoLip_ATPase_N PF16209.5 CDI74736.1 - 0.037 13.7 0.1 0.098 12.4 0.1 1.8 1 1 0 1 1 1 0 Phospholipid-translocating ATPase N-terminal TFIIA PF03153.13 CDI74736.1 - 0.071 13.1 23.8 0.071 13.1 23.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GNT-I PF03071.15 CDI74736.1 - 0.074 11.8 4.2 0.08 11.7 4.2 1.0 1 0 0 1 1 1 0 GNT-I family PRKCSH-like PF12999.7 CDI74736.1 - 0.16 11.8 8.8 0.19 11.5 8.8 1.1 1 0 0 1 1 1 0 Glucosidase II beta subunit-like TCP PF03634.13 CDI74736.1 - 0.17 12.4 15.4 0.21 12.1 15.4 1.2 1 0 0 1 1 1 0 TCP family transcription factor RR_TM4-6 PF06459.12 CDI74736.1 - 0.25 11.2 10.0 0.25 11.1 10.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SprA-related PF12118.8 CDI74736.1 - 0.3 10.2 25.2 0.38 9.9 25.2 1.1 1 0 0 1 1 1 0 SprA-related family Velvet PF11754.8 CDI74736.1 - 0.3 11.0 17.4 0.33 10.8 17.4 1.0 1 0 0 1 1 1 0 Velvet factor Roughex PF06020.11 CDI74736.1 - 0.42 9.7 8.5 0.45 9.6 8.5 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Pex14_N PF04695.13 CDI74736.1 - 0.5 11.0 19.6 0.55 10.9 19.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ASD2 PF08687.11 CDI74736.1 - 0.54 9.8 15.4 0.6 9.6 15.4 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Macoilin PF09726.9 CDI74736.1 - 0.66 8.5 15.8 0.91 8.0 15.8 1.2 1 0 0 1 1 1 0 Macoilin family DUF4407 PF14362.6 CDI74736.1 - 0.68 9.2 7.4 0.67 9.3 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Zip PF02535.22 CDI74736.1 - 0.69 9.1 9.6 0.79 8.9 9.6 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter PA26 PF04636.13 CDI74736.1 - 0.76 8.6 11.0 0.8 8.6 11.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Presenilin PF01080.17 CDI74736.1 - 1.9 7.1 17.0 2 7.1 17.0 1.0 1 0 0 1 1 1 0 Presenilin FAM199X PF15814.5 CDI74736.1 - 2 7.4 19.3 2.5 7.1 19.3 1.0 1 0 0 1 1 1 0 Protein family FAM199X SSP160 PF06933.11 CDI74736.1 - 2.1 6.5 14.7 2.4 6.3 14.7 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.12 CDI74736.1 - 2.5 5.9 13.9 2.6 5.9 13.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Med3 PF11593.8 CDI74736.1 - 2.6 7.1 23.1 3.3 6.8 23.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Suf PF05843.14 CDI74736.1 - 2.8 7.9 16.7 2.8 7.8 16.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MAJIN PF15077.6 CDI74736.1 - 2.9 7.6 9.8 2.9 7.6 9.8 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein DDHD PF02862.17 CDI74736.1 - 3.4 7.8 14.9 3.6 7.7 14.9 1.1 1 0 0 1 1 1 0 DDHD domain Band_3_cyto PF07565.13 CDI74736.1 - 3.5 7.4 11.2 3.7 7.3 11.2 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Ndc1_Nup PF09531.10 CDI74736.1 - 3.9 6.0 15.5 4.3 5.9 15.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hid1 PF12722.7 CDI74736.1 - 5.4 5.0 17.0 6 4.9 17.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 CDI74736.1 - 8 6.4 11.6 10 6.1 11.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 CDI74737.1 - 0.016 13.6 13.5 0.016 13.6 13.5 1.0 1 0 0 1 1 1 0 CDC45-like protein FAP PF07174.11 CDI74737.1 - 0.055 12.9 43.6 0.076 12.5 43.6 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) SAPS PF04499.15 CDI74737.1 - 0.092 11.5 12.3 0.076 11.8 12.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Apt1 PF10351.9 CDI74737.1 - 0.16 10.8 10.8 0.14 11.0 10.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain TFIIF_alpha PF05793.12 CDI74737.1 - 0.2 10.2 14.6 0.23 10.0 14.6 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NPR3 PF03666.13 CDI74737.1 - 0.3 9.8 18.5 0.31 9.8 18.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SpoIIP PF07454.11 CDI74737.1 - 0.35 10.3 19.8 0.44 10.0 19.8 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Otopetrin PF03189.13 CDI74737.1 - 0.54 9.0 9.1 0.48 9.2 9.1 1.1 1 0 0 1 1 1 0 Otopetrin FAM76 PF16046.5 CDI74737.1 - 0.69 9.2 20.9 0.81 9.0 20.9 1.1 1 0 0 1 1 1 0 FAM76 protein DUF2151 PF10221.9 CDI74737.1 - 0.72 8.4 10.5 0.7 8.4 10.5 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Peptidase_S64 PF08192.11 CDI74737.1 - 0.77 8.2 17.0 0.8 8.1 17.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 Cellulose_synt PF03552.14 CDI74737.1 - 1.5 7.3 4.9 1.5 7.2 4.9 1.0 1 0 0 1 1 1 0 Cellulose synthase Hid1 PF12722.7 CDI74737.1 - 1.7 6.6 19.8 1.6 6.8 19.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MDM10 PF12519.8 CDI74737.1 - 2.5 6.8 17.9 2.7 6.7 17.9 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SMN PF06003.12 CDI74737.1 - 2.8 7.1 14.0 3.4 6.8 14.0 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) AF-4 PF05110.13 CDI74737.1 - 3 5.8 31.8 3.4 5.6 31.8 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SLC12 PF03522.15 CDI74737.1 - 3.9 6.4 23.0 4.5 6.2 23.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Utp14 PF04615.13 CDI74737.1 - 6 5.3 27.0 7 5.1 27.0 1.0 1 0 0 1 1 1 0 Utp14 protein SOBP PF15279.6 CDI74737.1 - 9.5 6.7 36.5 11 6.5 36.5 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Rsc14 PF08586.10 CDI74739.1 - 0.012 16.4 3.4 0.012 16.4 3.4 7.9 4 2 3 8 8 8 0 RSC complex, Rsc14/Ldb7 subunit SPX PF03105.19 CDI74740.1 - 0.0013 18.8 15.5 0.0013 18.8 15.5 7.2 4 2 0 4 4 4 1 SPX domain ETRAMP PF09716.10 CDI74740.1 - 3.2 7.9 0.0 3.2 7.9 0.0 4.5 6 0 0 6 6 6 0 Malarial early transcribed membrane protein (ETRAMP) TRAPPC9-Trs120 PF08626.11 CDI74742.1 - 1.1e-08 33.0 0.0 1.1e-08 33.0 0.0 4.6 3 2 2 5 5 5 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Zip PF02535.22 CDI74742.1 - 0.82 8.8 6.7 0.41 9.8 0.8 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter Tim54 PF11711.8 CDI74742.1 - 1 8.1 4.5 6.6 5.4 0.0 3.3 3 1 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 ABC2_membrane_2 PF12679.7 CDI74743.1 - 0.67 9.2 0.0 0.67 9.2 0.0 3.3 4 0 0 4 4 4 0 ABC-2 family transporter protein Herpes_UL74 PF07982.12 CDI74743.1 - 5.7 5.8 7.4 0.46 9.4 1.3 2.2 2 0 0 2 2 2 0 Herpes UL74 glycoproteins DUF2339 PF10101.9 CDI74743.1 - 9.5 4.7 20.8 25 3.3 20.9 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2339) Ribosomal_S19e PF01090.19 CDI74744.1 - 0.062 13.0 0.0 2.9 7.6 0.0 2.0 1 1 1 2 2 2 0 Ribosomal protein S19e Caps_synth_GfcC PF06251.11 CDI74744.1 - 0.075 12.6 1.0 0.093 12.3 1.0 1.0 1 0 0 1 1 1 0 Capsule biosynthesis GfcC Sdh5 PF03937.16 CDI74744.1 - 0.099 12.6 1.2 0.15 12.0 1.2 1.3 1 0 0 1 1 1 0 Flavinator of succinate dehydrogenase DUF5523 PF17661.1 CDI74745.1 - 0.021 14.5 16.2 0.024 14.3 16.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Tir_receptor_N PF07490.11 CDI74745.1 - 0.031 14.1 0.8 0.043 13.6 0.8 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) N-terminus SpoIIP PF07454.11 CDI74745.1 - 0.043 13.3 15.9 0.05 13.1 15.9 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF1980 PF09323.10 CDI74745.1 - 0.049 13.5 13.3 0.072 13.0 13.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Ribosomal_60s PF00428.19 CDI74745.1 - 0.067 13.8 23.6 0.081 13.5 6.1 2.6 2 1 1 3 3 2 0 60s Acidic ribosomal protein FAM60A PF15396.6 CDI74745.1 - 0.068 13.2 15.7 0.082 12.9 15.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SOBP PF15279.6 CDI74745.1 - 0.097 13.3 15.2 0.1 13.2 15.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Lin-8 PF03353.15 CDI74745.1 - 0.12 12.0 21.4 0.12 11.9 21.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CDK5_activator PF03261.15 CDI74745.1 - 0.16 11.5 13.3 0.17 11.4 13.3 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein RRT14 PF17075.5 CDI74745.1 - 0.19 11.8 23.4 0.27 11.4 23.4 1.1 1 0 0 1 1 1 0 Regular of rDNA transcription protein 14 eIF-3_zeta PF05091.12 CDI74745.1 - 0.2 10.6 27.2 0.25 10.3 27.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) LptF_LptG PF03739.14 CDI74745.1 - 0.22 10.3 7.5 0.29 10.0 7.5 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG SLC12 PF03522.15 CDI74745.1 - 0.24 10.4 19.2 0.25 10.3 19.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 BORG_CEP PF14957.6 CDI74745.1 - 0.24 12.5 11.1 0.3 12.3 11.1 1.3 1 0 0 1 1 1 0 Cdc42 effector Presenilin PF01080.17 CDI74745.1 - 0.25 10.1 22.8 0.26 10.0 22.8 1.1 1 0 0 1 1 1 0 Presenilin Band_3_cyto PF07565.13 CDI74745.1 - 0.29 10.9 14.7 0.35 10.6 14.7 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CDC45 PF02724.14 CDI74745.1 - 0.31 9.3 15.6 0.31 9.3 15.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 CDI74745.1 - 0.34 10.9 15.1 0.33 11.0 15.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Dsh_C PF12316.8 CDI74745.1 - 0.39 11.1 14.1 0.47 10.8 14.1 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DDHD PF02862.17 CDI74745.1 - 0.4 10.8 17.0 0.46 10.6 17.0 1.2 1 0 0 1 1 1 0 DDHD domain NPR3 PF03666.13 CDI74745.1 - 0.48 9.2 16.1 0.52 9.0 16.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Connexin PF00029.19 CDI74745.1 - 0.52 10.0 13.0 0.66 9.7 13.0 1.3 1 0 0 1 1 1 0 Connexin Velvet PF11754.8 CDI74745.1 - 0.52 10.2 15.0 0.56 10.1 15.0 1.2 1 0 0 1 1 1 0 Velvet factor Gti1_Pac2 PF09729.9 CDI74745.1 - 0.56 10.3 15.2 0.7 10.0 15.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Pex14_N PF04695.13 CDI74745.1 - 0.57 10.8 33.6 1.1 9.9 33.6 1.5 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MMR1 PF08505.10 CDI74745.1 - 0.69 10.2 22.0 0.79 10.0 22.0 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein RR_TM4-6 PF06459.12 CDI74745.1 - 0.83 9.4 22.0 0.98 9.2 22.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4569 PF15133.6 CDI74745.1 - 0.84 9.3 20.9 0.94 9.1 20.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Membralin PF09746.9 CDI74745.1 - 0.86 8.6 12.9 0.96 8.4 12.9 1.0 1 0 0 1 1 1 0 Tumour-associated protein SID-1_RNA_chan PF13965.6 CDI74745.1 - 0.9 7.9 11.1 0.96 7.8 11.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Radical_SAM_N PF08497.10 CDI74745.1 - 0.95 8.6 11.6 1 8.5 11.6 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal ALMT PF11744.8 CDI74745.1 - 1.1 8.0 16.6 1.3 7.8 16.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter TFIIA PF03153.13 CDI74745.1 - 1.2 9.1 49.5 1.5 8.7 49.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF913 PF06025.12 CDI74745.1 - 1.3 8.0 10.5 1.3 7.9 10.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Cellulose_synt PF03552.14 CDI74745.1 - 1.4 7.3 8.5 1.6 7.2 8.5 1.0 1 0 0 1 1 1 0 Cellulose synthase Sec62 PF03839.16 CDI74745.1 - 1.5 8.3 18.5 1.8 8.0 18.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Endostatin PF06482.11 CDI74745.1 - 1.6 8.1 19.6 1.8 7.9 19.6 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Tim54 PF11711.8 CDI74745.1 - 1.6 7.4 18.3 1.9 7.2 18.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4638 PF15472.6 CDI74745.1 - 1.6 8.4 16.6 1.9 8.1 16.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Saw1 PF11561.8 CDI74745.1 - 1.7 8.2 14.9 2.2 7.7 14.9 1.3 1 0 0 1 1 1 0 Single strand annealing-weakened 1 DUF2828 PF11443.8 CDI74745.1 - 1.9 6.5 20.2 2.1 6.3 20.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Hid1 PF12722.7 CDI74745.1 - 2.5 6.1 18.8 2.6 6.1 18.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PIG-S PF10510.9 CDI74745.1 - 2.8 6.7 18.4 3.1 6.5 18.4 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein XRN_M PF17846.1 CDI74745.1 - 3.1 6.7 15.6 3.4 6.5 15.6 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Folliculin PF11704.8 CDI74745.1 - 3.1 7.6 13.6 4.2 7.2 13.6 1.4 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport MMM1 PF10296.9 CDI74745.1 - 3.2 6.7 12.7 3.9 6.4 12.7 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 DUF4746 PF15928.5 CDI74745.1 - 3.5 7.0 18.7 4.2 6.7 18.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PRP1_N PF06424.12 CDI74745.1 - 3.6 8.0 22.8 17 5.8 22.8 1.9 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal PAT1 PF09770.9 CDI74745.1 - 3.8 5.7 34.7 3.8 5.7 34.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 F-protein PF00469.20 CDI74745.1 - 3.9 7.0 17.3 5 6.7 17.3 1.3 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Draxin PF15550.6 CDI74745.1 - 4 7.2 17.5 4 7.2 17.5 1.0 1 0 0 1 1 1 0 Draxin Plasmodium_Vir PF05795.11 CDI74745.1 - 4.3 6.7 11.7 4.4 6.6 11.7 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Zip PF02535.22 CDI74745.1 - 4.9 6.3 12.6 5.4 6.1 12.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Asp-B-Hydro_N PF05279.11 CDI74745.1 - 5.4 7.0 19.5 5.7 6.9 19.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region MDM10 PF12519.8 CDI74745.1 - 5.6 5.7 17.5 6.1 5.6 17.5 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 TFB6 PF17110.5 CDI74745.1 - 5.7 6.6 13.3 8.1 6.2 13.3 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CSG2 PF16965.5 CDI74745.1 - 5.9 5.7 12.8 6.9 5.5 12.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Paramyxo_ncap PF00973.19 CDI74745.1 - 6.4 5.6 16.3 6.6 5.5 16.3 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein FAM176 PF14851.6 CDI74745.1 - 6.8 6.3 13.1 10 5.8 13.1 1.4 1 0 0 1 1 1 0 FAM176 family Glyco_transf_41 PF13844.6 CDI74745.1 - 7 5.0 12.3 7.3 4.9 12.3 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 MAJIN PF15077.6 CDI74745.1 - 7.1 6.3 16.4 8.9 6.0 16.4 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Hamartin PF04388.12 CDI74745.1 - 7.2 5.1 21.5 7.9 5.0 21.5 1.0 1 0 0 1 1 1 0 Hamartin protein Conotoxin PF02950.17 CDI74747.1 - 0.02 15.9 1.2 0.02 15.9 1.2 4.2 3 0 0 3 3 3 0 Conotoxin WBP-1 PF11669.8 CDI74747.1 - 2.4 8.8 9.6 0.23 12.1 0.4 3.1 3 0 0 3 3 3 0 WW domain-binding protein 1 EphA2_TM PF14575.6 CDI74747.1 - 9.2 7.2 7.2 7.5 7.5 0.2 3.5 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain SelP_N PF04592.14 CDI74748.1 - 0.061 12.7 35.4 0.073 12.5 35.4 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Myc_N PF01056.18 CDI74748.1 - 0.23 11.3 12.6 0.29 11.0 12.6 1.0 1 0 0 1 1 1 0 Myc amino-terminal region DUF688 PF05097.12 CDI74748.1 - 2 7.5 19.3 2.2 7.4 19.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF688) FAM60A PF15396.6 CDI74748.1 - 2.4 8.1 19.2 2.7 7.9 19.2 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Macoilin PF09726.9 CDI74748.1 - 3.1 6.2 21.9 3.8 5.9 21.9 1.1 1 0 0 1 1 1 0 Macoilin family V_ATPase_I PF01496.19 CDI74748.1 - 3.7 5.3 28.0 4 5.2 28.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Gti1_Pac2 PF09729.9 CDI74748.1 - 4.1 7.5 20.8 4.5 7.3 20.8 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family VIT1 PF01988.19 CDI74748.1 - 4.9 7.0 16.5 5.9 6.7 16.5 1.1 1 0 0 1 1 1 0 VIT family DUF3295 PF11702.8 CDI74748.1 - 8 5.7 24.3 9.1 5.5 24.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DUF1764 PF08576.10 CDI74748.1 - 9.9 7.1 20.9 16 6.5 20.9 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF2464 PF10240.9 CDI74748.1 - 9.9 5.6 17.2 12 5.4 17.2 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 LsmAD PF06741.13 CDI74750.1 - 0.00015 22.2 4.8 0.00015 22.2 4.8 6.8 6 1 1 7 7 7 1 LsmAD domain DUF2722 PF10846.8 CDI74750.1 - 0.0028 16.7 15.9 0.0028 16.7 15.9 11.3 4 2 2 8 8 8 1 Protein of unknown function (DUF2722) DUF755 PF05501.11 CDI74750.1 - 0.012 15.9 27.5 0.012 15.9 27.5 11.8 6 2 4 10 10 10 0 Domain of unknown function (DUF755) Dsh_C PF12316.8 CDI74751.1 - 0.0067 16.9 2.4 0.0067 16.9 2.4 2.8 2 1 0 2 2 2 1 Segment polarity protein dishevelled (Dsh) C terminal Suf PF05843.14 CDI74751.1 - 1.5 8.7 26.8 3.1 7.7 9.0 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) PTPRCAP PF15713.5 CDI74751.1 - 4.9 7.4 35.0 1.7 8.9 12.7 3.1 3 0 0 3 3 3 0 Protein tyrosine phosphatase receptor type C-associated Pkinase PF00069.25 CDI74752.1 - 1.4e-17 63.9 0.1 4.6e-14 52.4 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI74752.1 - 1.6e-10 40.7 0.0 2e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI74752.1 - 0.0035 16.7 0.0 0.0055 16.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDI74752.1 - 0.13 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Chromo PF00385.24 CDI74753.1 - 9e-07 28.7 0.0 1.4e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF2201_N PF13203.6 CDI74753.1 - 0.028 14.0 0.9 0.027 14.1 0.9 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain LCAT PF02450.15 CDI74754.1 - 1.1e-23 84.1 0.0 1.7e-21 76.8 0.0 2.6 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase zf-RING_2 PF13639.6 CDI74755.1 - 2.5e-05 24.5 10.1 2.5e-05 24.5 10.1 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 CDI74755.1 - 0.00018 21.4 7.8 0.00059 19.7 7.8 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CDI74755.1 - 0.00034 20.6 7.7 0.00085 19.3 7.0 2.1 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 CDI74755.1 - 0.0011 18.7 4.9 0.0028 17.4 4.9 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDI74755.1 - 0.0023 17.8 10.8 0.0056 16.5 10.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 CDI74755.1 - 0.0033 17.4 8.3 0.0082 16.2 8.3 1.7 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4 PF00097.25 CDI74755.1 - 0.029 14.2 6.9 0.097 12.6 6.9 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CDI74755.1 - 0.033 13.8 8.2 0.13 11.9 8.3 2.0 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type YPEB PF14620.6 CDI74755.1 - 0.04 13.3 1.5 0.051 12.9 0.2 1.7 1 1 1 2 2 2 0 YpeB sporulation Cnn_1N PF07989.11 CDI74755.1 - 0.15 12.2 5.1 0.16 12.1 0.8 2.2 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 DUF745 PF05335.13 CDI74755.1 - 1.1 9.0 6.2 1.7 8.4 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Prok-RING_1 PF14446.6 CDI74755.1 - 2.7 8.0 12.2 28 4.7 12.2 2.3 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 PI3K_1B_p101 PF10486.9 CDI74756.1 - 0.47 8.2 11.3 0.76 7.5 11.3 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Macoilin PF09726.9 CDI74757.1 - 1 7.9 28.0 0.0031 16.2 15.5 2.1 2 0 0 2 2 2 0 Macoilin family Med15 PF09606.10 CDI74757.1 - 2 7.0 83.3 0.23 10.1 17.7 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal SMYLE_N PF18615.1 CDI74757.1 - 6.8 6.1 34.0 15 5.0 28.0 2.2 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain RskA PF10099.9 CDI74758.1 - 3.7e-06 27.4 115.1 0.091 13.1 38.7 6.7 1 1 2 4 4 4 3 Anti-sigma-K factor rskA AAA_23 PF13476.6 CDI74758.1 - 0.0061 17.1 3.6 0.0061 17.1 3.6 5.4 2 1 1 3 3 3 1 AAA domain WhiA_N PF10298.9 CDI74758.1 - 0.0063 16.5 1.4 0.019 15.0 1.4 1.8 1 0 0 1 1 1 1 WhiA N-terminal LAGLIDADG-like domain AgrB PF04647.15 CDI74759.1 - 0.11 11.8 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Accessory gene regulator B DUF2207 PF09972.9 CDI74759.1 - 0.26 10.0 0.2 0.74 8.5 0.0 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Kri1 PF05178.12 CDI74759.1 - 6.3 7.4 0.0 6.3 7.4 0.0 4.9 4 1 1 5 5 5 0 KRI1-like family Pkinase PF00069.25 CDI74760.1 - 1.5e-31 109.7 0.9 1.7e-28 99.7 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI74760.1 - 8e-10 38.4 1.4 5.9e-07 29.0 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 CDI74760.1 - 0.00014 21.9 19.9 0.00019 21.4 19.9 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family Presenilin PF01080.17 CDI74760.1 - 0.00024 20.0 2.5 0.00025 19.9 2.5 1.1 1 0 0 1 1 1 1 Presenilin Suf PF05843.14 CDI74760.1 - 0.00039 20.5 8.3 0.00054 20.0 8.3 1.3 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Pkinase_fungal PF17667.1 CDI74760.1 - 0.00048 19.0 7.1 0.00091 18.1 7.1 1.4 1 1 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDI74760.1 - 0.0025 17.2 1.2 0.0047 16.3 1.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SAGA-Tad1 PF12767.7 CDI74760.1 - 0.0034 17.2 2.3 0.0037 17.0 2.3 1.1 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit DUF913 PF06025.12 CDI74760.1 - 0.0058 15.6 2.3 0.0077 15.2 2.3 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Choline_kinase PF01633.20 CDI74760.1 - 0.0061 16.2 0.2 0.0061 16.2 0.2 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase CDK2AP PF09806.9 CDI74760.1 - 0.0064 16.6 18.1 0.01 15.9 18.1 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase 2-associated protein Tim54 PF11711.8 CDI74760.1 - 0.0086 14.9 3.4 0.012 14.4 3.4 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 PIP5K PF01504.18 CDI74760.1 - 0.0094 15.2 2.4 0.012 14.8 2.4 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF2828 PF11443.8 CDI74760.1 - 0.016 13.3 6.7 0.022 12.9 6.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Ndc1_Nup PF09531.10 CDI74760.1 - 0.02 13.6 10.5 0.023 13.4 10.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ASD2 PF08687.11 CDI74760.1 - 0.02 14.4 10.9 0.028 14.0 10.9 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 SMYLE_N PF18615.1 CDI74760.1 - 0.022 14.3 3.3 0.029 14.0 3.3 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Sin_N PF04801.13 CDI74760.1 - 0.022 14.0 14.8 0.028 13.7 14.8 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region RR_TM4-6 PF06459.12 CDI74760.1 - 0.028 14.3 9.9 0.036 13.9 9.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4551 PF15087.6 CDI74760.1 - 0.036 12.9 5.0 0.043 12.6 5.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Trp_oprn_chp PF09534.10 CDI74760.1 - 0.082 12.7 6.5 0.17 11.7 6.5 1.5 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) CLN3 PF02487.17 CDI74760.1 - 0.088 11.8 4.5 0.12 11.4 4.5 1.1 1 0 0 1 1 1 0 CLN3 protein PAT1 PF09770.9 CDI74760.1 - 0.18 10.0 18.9 0.25 9.6 18.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BAT2_N PF07001.11 CDI74760.1 - 0.19 12.2 17.9 0.36 11.3 17.9 1.4 1 0 0 1 1 1 0 BAT2 N-terminus DUF2052 PF09747.9 CDI74760.1 - 0.28 11.3 9.4 0.48 10.5 9.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4484 PF14831.6 CDI74760.1 - 0.4 10.7 7.7 0.68 9.9 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) SLC12 PF03522.15 CDI74760.1 - 0.41 9.6 7.9 0.52 9.3 7.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Zip PF02535.22 CDI74760.1 - 0.44 9.7 2.0 0.51 9.5 2.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Gti1_Pac2 PF09729.9 CDI74760.1 - 0.46 10.6 6.8 0.69 10.0 6.8 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family IHABP4_N PF16174.5 CDI74760.1 - 0.5 10.9 17.6 1 9.9 17.6 1.5 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal FAM60A PF15396.6 CDI74760.1 - 0.6 10.1 8.1 0.88 9.5 8.1 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Hid1 PF12722.7 CDI74760.1 - 0.67 8.0 9.1 0.81 7.7 9.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SARAF PF06682.12 CDI74760.1 - 0.7 9.5 11.3 0.94 9.1 11.3 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis FTA2 PF13095.6 CDI74760.1 - 0.76 9.4 11.0 4.3 6.9 11.0 2.0 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 WTX PF09422.10 CDI74760.1 - 0.87 8.6 11.5 1.2 8.2 11.5 1.0 1 0 0 1 1 1 0 WTX protein DUF4647 PF15504.6 CDI74760.1 - 0.89 8.6 11.6 1.2 8.1 11.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Folliculin PF11704.8 CDI74760.1 - 1 9.2 8.6 1.6 8.6 8.6 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Rsc14 PF08586.10 CDI74760.1 - 1.2 9.9 4.9 4.1 8.3 0.7 2.2 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit BAF1_ABF1 PF04684.13 CDI74760.1 - 1.3 8.0 13.2 1.6 7.7 13.2 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4569 PF15133.6 CDI74760.1 - 1.3 8.6 11.9 2.1 8.0 11.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) ALMT PF11744.8 CDI74760.1 - 1.6 7.5 7.7 2.1 7.1 7.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4400 PF14348.6 CDI74760.1 - 1.8 8.1 5.0 2.6 7.5 5.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) DUF908 PF06012.12 CDI74760.1 - 2.2 7.6 11.0 3 7.2 11.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Lin-8 PF03353.15 CDI74760.1 - 2.6 7.5 13.3 3.9 7.0 13.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Rtf2 PF04641.12 CDI74760.1 - 3.7 6.8 10.9 5.1 6.4 10.9 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger USP8_interact PF08941.10 CDI74760.1 - 4.5 7.0 10.6 0.68 9.7 1.7 2.2 2 0 0 2 2 2 0 USP8 interacting GET2 PF08690.10 CDI74760.1 - 6.3 6.4 14.0 8.8 5.9 14.0 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 V_ATPase_I PF01496.19 CDI74760.1 - 6.8 4.5 9.9 9.1 4.1 9.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FAM70 PF14967.6 CDI74760.1 - 7.7 5.9 7.3 10 5.5 7.3 1.3 1 0 0 1 1 1 0 FAM70 protein DivIC PF04977.15 CDI74760.1 - 8.7 6.2 21.5 4.6 7.1 7.3 2.3 2 0 0 2 2 2 0 Septum formation initiator MGC-24 PF05283.11 CDI74760.1 - 8.9 6.8 8.4 14 6.1 8.4 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin RskA PF10099.9 CDI74760.1 - 9 6.5 32.3 18 5.5 32.3 1.5 1 1 0 1 1 1 0 Anti-sigma-K factor rskA PIF3 PF05006.12 CDI74761.1 - 0.37 10.9 4.9 0.6 10.2 4.9 1.3 1 0 0 1 1 1 0 Per os infectivity factor 3 SPX PF03105.19 CDI74761.1 - 0.4 10.6 11.0 0.46 10.4 11.0 1.1 1 0 0 1 1 1 0 SPX domain Mitofilin PF09731.9 CDI74761.1 - 3.2 6.5 14.1 3.5 6.4 14.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Mucin PF01456.17 CDI74762.1 - 0.26 11.2 16.1 0.031 14.3 6.0 2.2 1 1 1 2 2 2 0 Mucin-like glycoprotein DUF3246 PF11596.8 CDI74762.1 - 2 7.8 12.4 6 6.2 12.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3246) SpoIIIAH PF12685.7 CDI74764.1 - 0.11 12.3 12.2 0.12 12.2 12.2 1.0 1 0 0 1 1 1 0 SpoIIIAH-like protein MGC-24 PF05283.11 CDI74764.1 - 2 8.9 9.0 2.4 8.6 9.0 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin TraV PF09676.10 CDI74764.1 - 2.5 9.1 10.4 2.7 9.0 10.4 1.1 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) DUF3824 PF12868.7 CDI74765.1 - 0.0031 18.2 4.3 0.0031 18.2 4.3 7.9 6 1 1 7 7 7 1 Domain of unknwon function (DUF3824) XRN_M PF17846.1 CDI74766.1 - 1.6e-12 47.1 0.1 1.6e-12 47.1 0.1 5.6 2 1 3 6 6 3 1 Xrn1 helical domain DUF4834 PF16118.5 CDI74766.1 - 3.4e-07 31.1 3.1 3.4e-07 31.1 3.1 5.8 3 1 2 5 5 3 2 Domain of unknown function (DUF4834) RskA PF10099.9 CDI74766.1 - 9.7e-07 29.2 9.4 9.7e-07 29.2 9.4 6.6 2 2 3 5 5 3 2 Anti-sigma-K factor rskA V_ATPase_I PF01496.19 CDI74766.1 - 0.00054 18.0 10.7 0.00054 18.0 10.7 4.2 3 1 0 4 4 2 2 V-type ATPase 116kDa subunit family T2SSM PF04612.12 CDI74766.1 - 0.001 19.2 13.7 0.001 19.2 13.7 7.9 4 2 4 8 8 1 1 Type II secretion system (T2SS), protein M CBP_BcsG PF11658.8 CDI74766.1 - 0.0012 17.4 2.4 0.0012 17.4 2.4 5.1 4 1 1 5 5 3 1 Cellulose biosynthesis protein BcsG DUF4131 PF13567.6 CDI74766.1 - 0.0021 17.7 3.7 0.0021 17.7 3.7 2.9 2 1 0 2 2 1 1 Domain of unknown function (DUF4131) SID-1_RNA_chan PF13965.6 CDI74766.1 - 0.0026 16.3 0.3 0.0026 16.3 0.3 3.6 3 1 0 3 3 2 2 dsRNA-gated channel SID-1 Connexin PF00029.19 CDI74766.1 - 0.0028 17.4 1.4 0.0028 17.4 1.4 5.2 3 1 0 3 3 2 2 Connexin YfhO PF09586.10 CDI74766.1 - 0.0045 15.3 5.0 0.0045 15.3 5.0 3.1 3 0 0 3 3 2 1 Bacterial membrane protein YfhO CLN3 PF02487.17 CDI74766.1 - 0.0053 15.8 3.3 0.0053 15.8 3.3 4.5 3 1 0 3 3 2 1 CLN3 protein Eapp_C PF10238.9 CDI74766.1 - 0.006 16.7 0.7 0.006 16.7 0.7 5.8 3 1 1 5 5 4 1 E2F-associated phosphoprotein Tmemb_9 PF05434.11 CDI74766.1 - 0.0067 16.3 3.6 0.0067 16.3 3.6 5.4 3 1 2 5 5 2 1 TMEM9 eIF-3_zeta PF05091.12 CDI74766.1 - 0.0071 15.4 2.9 0.0071 15.4 2.9 4.5 3 1 1 4 4 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TCP PF03634.13 CDI74766.1 - 0.0086 16.6 0.1 0.0086 16.6 0.1 5.6 2 1 0 3 3 1 1 TCP family transcription factor FAM176 PF14851.6 CDI74766.1 - 0.0088 15.7 2.1 0.0088 15.7 2.1 5.4 3 1 0 4 4 3 2 FAM176 family TRAP_alpha PF03896.16 CDI74766.1 - 0.014 14.6 1.5 0.014 14.6 1.5 5.3 3 1 1 5 5 4 0 Translocon-associated protein (TRAP), alpha subunit HemY_N PF07219.13 CDI74766.1 - 0.017 15.3 1.5 0.017 15.3 1.5 7.6 5 3 1 7 7 1 0 HemY protein N-terminus Wzy_C PF04932.15 CDI74766.1 - 0.023 14.3 0.0 0.095 12.3 0.0 2.0 2 0 0 2 2 2 0 O-Antigen ligase Pex24p PF06398.11 CDI74766.1 - 0.027 13.5 0.5 0.027 13.5 0.5 3.0 3 1 0 3 3 2 0 Integral peroxisomal membrane peroxin BSMAP PF12280.8 CDI74766.1 - 0.027 14.7 0.3 0.027 14.7 0.3 5.2 3 1 1 4 4 3 0 Brain specific membrane anchored protein SARAF PF06682.12 CDI74766.1 - 0.039 13.6 0.6 0.039 13.6 0.6 3.7 2 1 0 3 3 2 0 SOCE-associated regulatory factor of calcium homoeostasis DAG_kinase_N PF14513.6 CDI74766.1 - 0.05 13.8 0.3 0.05 13.8 0.3 4.8 2 1 2 4 4 3 0 Diacylglycerol kinase N-terminus SpoIIIAH PF12685.7 CDI74766.1 - 0.053 13.4 0.2 0.053 13.4 0.2 5.4 2 1 0 2 2 1 0 SpoIIIAH-like protein Ion_trans PF00520.31 CDI74766.1 - 0.068 12.4 0.1 0.1 11.8 0.1 1.2 1 0 0 1 1 1 0 Ion transport protein Lipase_GDSL PF00657.22 CDI74766.1 - 0.078 12.9 0.1 0.078 12.9 0.1 5.2 4 1 0 4 4 3 0 GDSL-like Lipase/Acylhydrolase Dpy19 PF10034.9 CDI74766.1 - 0.1 10.8 0.0 0.1 10.8 0.0 4.4 3 2 2 5 5 4 0 Q-cell neuroblast polarisation Kei1 PF08552.11 CDI74766.1 - 0.4 10.5 0.0 0.4 10.5 0.0 6.5 4 1 0 4 4 3 0 Inositolphosphorylceramide synthase subunit Kei1 Shisa PF13908.6 CDI74766.1 - 0.5 10.6 0.0 0.5 10.6 0.0 5.5 3 1 1 5 5 2 0 Wnt and FGF inhibitory regulator DUF4389 PF14333.6 CDI74766.1 - 0.84 9.6 7.1 1.6 8.7 7.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) TMEM51 PF15345.6 CDI74766.1 - 2.5 7.9 88.6 0.028 14.3 2.3 5.9 4 1 1 5 5 4 0 Transmembrane protein 51 TFIIA PF03153.13 CDI74768.1 - 0.0013 18.8 5.5 0.0014 18.7 5.5 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI74768.1 - 0.0021 17.7 2.7 0.0027 17.4 2.7 1.3 1 0 0 1 1 1 1 Spt20 family SUIM_assoc PF16619.5 CDI74768.1 - 0.0037 17.3 5.0 0.0067 16.5 5.0 1.5 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Tyrosinase PF00264.20 CDI74768.1 - 0.041 14.2 0.3 0.05 13.9 0.3 1.1 1 0 0 1 1 1 0 Common central domain of tyrosinase DUF2722 PF10846.8 CDI74768.1 - 0.24 10.3 7.9 0.03 13.3 1.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) RskA PF10099.9 CDI74770.1 - 7.4e-06 26.4 8.0 7.4e-06 26.4 8.0 2.3 1 1 1 2 2 1 1 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI74770.1 - 0.063 12.0 37.3 0.063 12.0 37.3 1.2 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI74770.1 - 0.16 11.8 33.1 0.17 11.7 33.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI74770.1 - 0.34 9.1 53.9 0.33 9.2 53.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CCSAP PF15748.5 CDI74770.1 - 0.44 10.7 37.5 0.48 10.5 37.5 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated LicD PF04991.13 CDI74770.1 - 0.69 10.0 13.8 0.79 9.8 13.8 1.0 1 0 0 1 1 1 0 LicD family CDC45 PF02724.14 CDI74770.1 - 1.3 7.2 30.3 1.4 7.1 30.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Endostatin PF06482.11 CDI74770.1 - 1.8 7.9 31.7 2.3 7.6 31.7 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin NPR3 PF03666.13 CDI74770.1 - 2.1 7.0 35.0 2.5 6.8 35.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SID-1_RNA_chan PF13965.6 CDI74770.1 - 3.2 6.1 15.5 4.1 5.7 15.5 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ALMT PF11744.8 CDI74770.1 - 3.8 6.2 26.9 3.9 6.2 26.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4045 PF13254.6 CDI74770.1 - 3.8 7.0 30.3 4.2 6.9 30.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) VIR_N PF15912.5 CDI74770.1 - 4 6.9 23.0 4.8 6.7 23.0 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal XRN_M PF17846.1 CDI74770.1 - 4.8 6.0 24.9 4.7 6.1 24.9 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Asp-B-Hydro_N PF05279.11 CDI74770.1 - 5 7.1 24.2 4.9 7.1 24.2 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Nop53 PF07767.11 CDI74770.1 - 5.6 6.2 42.9 6.4 6.1 42.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF2052 PF09747.9 CDI74770.1 - 6 7.0 33.8 7 6.7 33.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF1180 PF06679.12 CDI74771.1 - 0.0013 19.1 3.9 0.0022 18.5 3.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) MID_MedPIWI PF18296.1 CDI74771.1 - 0.0091 15.8 5.9 0.011 15.5 5.9 1.1 1 0 0 1 1 1 1 MID domain of medPIWI DUF4834 PF16118.5 CDI74771.1 - 0.012 16.6 1.1 0.012 16.6 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ctr PF04145.15 CDI74771.1 - 0.012 16.2 2.9 0.017 15.8 2.8 1.3 1 1 0 1 1 1 0 Ctr copper transporter family V_ATPase_I PF01496.19 CDI74771.1 - 0.013 13.5 1.0 0.013 13.4 1.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1635 PF07795.11 CDI74771.1 - 0.024 14.5 9.8 0.031 14.1 9.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) RIFIN PF02009.16 CDI74771.1 - 0.038 13.9 5.8 0.048 13.6 5.8 1.1 1 0 0 1 1 1 0 Rifin MRI PF15325.6 CDI74771.1 - 0.045 14.8 0.8 0.077 14.1 0.8 1.3 1 0 0 1 1 1 0 Modulator of retrovirus infection Pkinase_fungal PF17667.1 CDI74771.1 - 0.32 9.7 4.0 0.38 9.5 4.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Corazonin PF17308.2 CDI74771.1 - 0.59 10.5 9.1 0.78 10.1 9.1 1.1 1 0 0 1 1 1 0 Pro-corazonin ANAPC_CDC26 PF10471.9 CDI74771.1 - 1 10.2 10.6 1.4 9.8 10.6 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 DUF898 PF05987.13 CDI74771.1 - 1.7 7.6 3.9 1.1 8.3 1.1 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Conotoxin PF02950.17 CDI74771.1 - 1.9 9.6 7.4 4.7 8.3 7.4 1.8 1 1 0 1 1 1 0 Conotoxin Macoilin PF09726.9 CDI74771.1 - 7.4 5.0 11.6 9 4.7 11.6 1.0 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI74772.1 - 0.13 12.3 27.4 0.16 11.9 27.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Antistasin PF02822.14 CDI74773.1 - 0.059 14.0 5.4 0.091 13.4 5.4 1.3 1 0 0 1 1 1 0 Antistasin family BAF1_ABF1 PF04684.13 CDI74773.1 - 0.46 9.5 27.7 0.56 9.2 27.7 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor LAP1C PF05609.12 CDI74773.1 - 3.5 6.6 24.5 4.3 6.3 24.5 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) EMG1 PF03587.14 CDI74774.1 - 4.6e-44 150.4 0.1 5.4e-35 120.8 0.1 2.1 1 1 1 2 2 2 2 EMG1/NEP1 methyltransferase Radial_spoke_3 PF06098.11 CDI74775.1 - 3.6e-09 36.3 12.0 3.6e-09 36.3 12.0 2.4 2 0 0 2 2 2 1 Radial spoke protein 3 TRM13 PF05206.14 CDI74776.1 - 2.4e-16 60.1 0.3 3.4e-07 30.0 0.0 4.6 4 1 1 5 5 5 3 Methyltransferase TRM13 zf-U11-48K PF05253.12 CDI74776.1 - 0.0032 17.3 0.1 0.0074 16.2 0.1 1.7 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger Vac14_Fig4_bd PF11916.8 CDI74777.1 - 1.2e-38 132.5 0.0 2.7e-38 131.4 0.0 1.6 1 1 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Shikimate_dh_N PF08501.11 CDI74778.1 - 1e-06 28.9 0.1 4.3e-05 23.7 0.0 3.2 2 0 0 2 2 2 1 Shikimate dehydrogenase substrate binding domain DUF2722 PF10846.8 CDI74778.1 - 0.00055 19.0 4.6 0.00055 19.0 4.6 13.8 9 3 5 14 14 14 3 Protein of unknown function (DUF2722) ASD2 PF08687.11 CDI74778.1 - 0.0033 17.0 24.5 0.0033 17.0 24.5 6.9 5 1 2 7 7 7 1 Apx/Shroom domain ASD2 RskA PF10099.9 CDI74778.1 - 0.0084 16.4 8.2 0.0084 16.4 8.2 16.8 5 3 10 16 16 16 2 Anti-sigma-K factor rskA EphA2_TM PF14575.6 CDI74779.1 - 0.0035 18.2 2.2 0.0035 18.2 2.2 7.0 3 2 0 3 3 3 1 Ephrin type-A receptor 2 transmembrane domain SR-25 PF10500.9 CDI74779.1 - 0.0063 16.1 15.6 0.0063 16.1 15.6 4.4 3 1 2 5 5 5 1 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI74779.1 - 0.012 15.9 0.0 0.012 15.9 0.0 8.6 1 1 6 7 7 7 0 Anti-sigma-K factor rskA DUF2207 PF09972.9 CDI74779.1 - 0.047 12.5 0.0 1.1 7.9 0.0 2.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Oxidored_q3 PF00499.20 CDI74779.1 - 0.062 13.0 0.1 4.1 7.1 0.0 2.8 3 0 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Coiled PF05710.12 CDI74779.1 - 0.43 11.4 13.2 1.9 9.4 13.2 2.1 1 0 0 1 1 1 0 Coiled coil RskA PF10099.9 CDI74781.1 - 0.014 15.7 10.2 0.016 15.5 10.2 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA FUSC PF04632.12 CDI74781.1 - 0.39 9.2 10.0 0.47 8.9 10.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Androgen_recep PF02166.16 CDI74781.1 - 0.55 9.0 10.0 0.67 8.7 10.0 1.1 1 0 0 1 1 1 0 Androgen receptor UBA PF00627.31 CDI74782.1 - 3.8e-11 42.6 0.2 1e-10 41.3 0.2 1.8 1 0 0 1 1 1 1 UBA/TS-N domain SDA1 PF05285.12 CDI74782.1 - 0.0015 18.1 0.2 0.0015 18.1 0.2 9.3 6 2 1 7 7 7 2 SDA1 RskA PF10099.9 CDI74782.1 - 0.065 13.5 0.1 0.065 13.5 0.1 18.4 3 3 7 10 10 10 0 Anti-sigma-K factor rskA Biotin_lipoyl PF00364.22 CDI74783.1 - 3.1e-12 46.1 0.0 5.5e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme DUF2722 PF10846.8 CDI74783.1 - 1.1e-05 24.5 4.4 1.1e-05 24.5 4.4 8.3 5 2 3 8 8 8 2 Protein of unknown function (DUF2722) RskA PF10099.9 CDI74783.1 - 0.002 18.5 23.5 0.0039 17.5 4.4 9.8 2 1 4 6 6 6 3 Anti-sigma-K factor rskA DUF3801 PF12687.7 CDI74783.1 - 0.0095 16.0 4.3 0.0095 16.0 4.3 5.6 3 1 1 4 4 4 2 Protein of unknown function (DUF3801) Promethin PF16015.5 CDI74783.1 - 0.15 12.0 0.1 0.15 12.0 0.1 3.2 2 0 0 2 2 2 0 Promethin SR-25 PF10500.9 CDI74783.1 - 2.6 7.6 65.6 0.31 10.6 12.9 4.7 5 0 0 5 5 5 0 Nuclear RNA-splicing-associated protein SR-25 PF10500.9 CDI74784.1 - 0.0006 19.5 22.9 0.0006 19.5 22.9 2.1 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein U1snRNP70_N PF12220.8 CDI74784.1 - 0.12 13.1 15.7 2.7 8.7 10.5 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal JUPITER PF17054.5 CDI74784.1 - 0.72 9.3 14.1 1 8.8 14.1 1.2 1 0 0 1 1 1 0 Microtubule-Associated protein Jupiter PAT1 PF09770.9 CDI74784.1 - 1.5 7.0 38.6 1.7 6.8 38.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AAA_23 PF13476.6 CDI74784.1 - 1.6 9.2 20.6 2.3 8.7 20.6 1.2 1 0 0 1 1 1 0 AAA domain DUF4834 PF16118.5 CDI74784.1 - 4 8.4 37.4 0.1 13.6 16.6 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) LAP1C PF05609.12 CDI74784.1 - 4.7 6.2 35.6 5.8 5.9 35.6 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SART-1 PF03343.13 CDI74784.1 - 8.4 4.8 28.8 12 4.3 28.8 1.1 1 0 0 1 1 1 0 SART-1 family RAP1 PF07218.11 CDI74784.1 - 9.5 4.4 13.6 19 3.4 13.6 1.5 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Usp PF00582.26 CDI74784.1 - 9.9 6.7 6.4 72 3.9 3.5 2.2 2 0 0 2 2 2 0 Universal stress protein family BAF1_ABF1 PF04684.13 CDI74785.1 - 0.033 13.3 22.9 0.037 13.1 22.9 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FCP1_C PF09309.10 CDI74785.1 - 0.47 10.3 25.7 0.56 10.0 25.7 1.1 1 0 0 1 1 1 0 FCP1, C-terminal DUF572 PF04502.13 CDI74785.1 - 1.3 8.6 25.6 1.8 8.1 25.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SMYLE_N PF18615.1 CDI74785.1 - 1.4 8.4 21.5 1.7 8.1 21.5 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain RR_TM4-6 PF06459.12 CDI74785.1 - 1.7 8.4 32.6 2.1 8.1 32.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Cwf_Cwc_15 PF04889.12 CDI74785.1 - 1.8 8.2 28.1 2.2 7.9 28.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NPR3 PF03666.13 CDI74785.1 - 2.2 7.0 25.6 2.6 6.7 25.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2828 PF11443.8 CDI74785.1 - 2.5 6.1 23.5 3.1 5.8 23.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PA26 PF04636.13 CDI74785.1 - 2.6 6.9 26.5 3 6.7 26.5 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4569 PF15133.6 CDI74785.1 - 2.9 7.5 29.4 3.2 7.4 29.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Presenilin PF01080.17 CDI74785.1 - 3.1 6.5 33.2 3.6 6.3 33.2 1.0 1 0 0 1 1 1 0 Presenilin CAF-1_p150 PF11600.8 CDI74785.1 - 3.1 7.5 30.7 3.8 7.2 30.7 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF4746 PF15928.5 CDI74785.1 - 3.4 7.0 27.2 4 6.8 27.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) ALMT PF11744.8 CDI74785.1 - 3.7 6.3 24.0 4.5 6.0 24.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Draxin PF15550.6 CDI74785.1 - 3.7 7.3 16.5 4.6 7.0 16.5 1.1 1 0 0 1 1 1 0 Draxin Menin PF05053.13 CDI74785.1 - 6.6 5.0 20.0 7.3 4.8 20.0 1.0 1 0 0 1 1 1 0 Menin NOA36 PF06524.12 CDI74785.1 - 7.1 5.9 18.9 10 5.4 18.9 1.2 1 0 0 1 1 1 0 NOA36 protein SLC12 PF03522.15 CDI74785.1 - 7.8 5.4 30.4 9.1 5.2 30.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Raftlin PF15250.6 CDI74785.1 - 8.1 5.1 24.1 9.3 4.9 24.1 1.0 1 0 0 1 1 1 0 Raftlin AAA_11 PF13086.6 CDI74786.1 - 0.0086 15.9 15.1 0.0086 15.9 15.1 2.6 2 1 0 2 2 2 1 AAA domain RskA PF10099.9 CDI74786.1 - 0.012 15.9 18.6 0.012 15.9 18.6 5.1 1 1 3 4 4 4 0 Anti-sigma-K factor rskA CAF1 PF04857.20 CDI74787.1 - 0.038 13.1 11.5 0.54 9.4 0.0 2.7 2 0 0 2 2 2 0 CAF1 family ribonuclease DUF2722 PF10846.8 CDI74787.1 - 0.14 11.1 59.0 0.067 12.1 0.8 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF2722) OATP PF03137.20 CDI74787.1 - 7.1 4.8 9.5 2.9 6.1 0.3 3.4 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF2722 PF10846.8 CDI74788.1 - 0.00026 20.1 18.2 0.00031 19.8 18.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Pet20 PF08692.10 CDI74788.1 - 0.0078 16.9 4.8 0.0098 16.6 4.8 1.2 1 0 0 1 1 1 1 Mitochondrial protein Pet20 Auxin_canalis PF05703.11 CDI74788.1 - 0.014 15.3 9.2 0.019 14.9 9.2 1.1 1 0 0 1 1 1 0 Auxin canalisation TFIIF_alpha PF05793.12 CDI74788.1 - 0.015 13.9 12.3 0.018 13.7 12.3 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SpoIIP PF07454.11 CDI74788.1 - 0.029 13.8 11.1 0.035 13.6 11.1 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FAM91_C PF14648.6 CDI74788.1 - 0.051 12.4 2.7 0.053 12.3 2.7 1.2 1 0 0 1 1 1 0 FAM91 C-terminus Bud13 PF09736.9 CDI74788.1 - 0.066 13.6 19.5 0.085 13.2 19.5 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Plasmodium_Vir PF05795.11 CDI74788.1 - 0.13 11.6 8.4 0.16 11.4 8.4 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein ABC2_membrane_2 PF12679.7 CDI74788.1 - 0.14 11.4 1.0 0.17 11.2 1.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein BT1 PF03092.16 CDI74788.1 - 0.18 10.0 2.3 0.2 9.9 2.3 1.1 1 0 0 1 1 1 0 BT1 family MMR1 PF08505.10 CDI74788.1 - 0.2 11.9 14.1 0.23 11.8 14.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SLC12 PF03522.15 CDI74788.1 - 0.38 9.7 12.4 0.41 9.6 12.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 CDI74788.1 - 0.39 8.9 12.9 0.45 8.8 12.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI74788.1 - 0.41 9.4 16.2 0.45 9.2 16.2 1.2 1 0 0 1 1 1 0 Presenilin XRN_M PF17846.1 CDI74788.1 - 0.41 9.5 8.6 0.48 9.3 8.6 1.1 1 0 0 1 1 1 0 Xrn1 helical domain MDM10 PF12519.8 CDI74788.1 - 0.46 9.3 9.4 0.47 9.2 9.4 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 eIF-3_zeta PF05091.12 CDI74788.1 - 0.51 9.2 16.5 0.58 9.1 16.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3123 PF11321.8 CDI74788.1 - 0.62 10.7 6.1 1 10.1 2.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) Otopetrin PF03189.13 CDI74788.1 - 0.91 8.3 3.0 0.91 8.3 3.0 1.1 1 0 0 1 1 1 0 Otopetrin ART-PolyVal PF18760.1 CDI74788.1 - 1.2 10.2 14.2 1.7 9.7 10.8 1.9 1 1 1 2 2 2 0 ADP-Ribosyltransferase in polyvalent proteins ALMT PF11744.8 CDI74788.1 - 1.3 7.8 9.2 1.4 7.7 9.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Mem_trans PF03547.18 CDI74788.1 - 1.3 7.3 4.5 1.6 7.0 4.5 1.1 1 0 0 1 1 1 0 Membrane transport protein Zip PF02535.22 CDI74788.1 - 1.5 8.0 6.9 1.6 7.8 6.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PAT1 PF09770.9 CDI74788.1 - 1.5 7.0 26.5 1.7 6.8 26.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Folate_carrier PF01770.18 CDI74788.1 - 2.2 6.9 5.6 2.7 6.6 5.6 1.1 1 0 0 1 1 1 0 Reduced folate carrier NPR3 PF03666.13 CDI74788.1 - 2.3 6.9 14.3 2.8 6.6 14.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ureide_permease PF07168.11 CDI74788.1 - 2.3 6.9 4.7 2.6 6.7 4.7 1.3 1 0 0 1 1 1 0 Ureide permease HCO3_cotransp PF00955.21 CDI74788.1 - 2.3 6.9 3.3 2.8 6.7 3.3 1.1 1 0 0 1 1 1 0 HCO3- transporter family Sporozoite_P67 PF05642.11 CDI74788.1 - 2.4 6.2 10.5 3.1 5.8 10.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SID-1_RNA_chan PF13965.6 CDI74788.1 - 3.1 6.1 6.3 3.5 5.9 6.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI74788.1 - 3.3 5.5 13.6 3.9 5.3 13.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CSG2 PF16965.5 CDI74788.1 - 3.9 6.3 5.3 4.9 6.0 5.3 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator DUF3597 PF12200.8 CDI74788.1 - 4.7 7.8 16.9 3.7 8.1 2.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) Anoctamin PF04547.12 CDI74788.1 - 4.7 5.9 5.4 5.2 5.8 5.4 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel Orf78 PF06024.12 CDI74788.1 - 5.6 7.3 8.2 6.6 7.1 6.5 1.9 2 0 0 2 2 2 0 Orf78 (ac78) Hid1 PF12722.7 CDI74788.1 - 6 4.9 17.8 6.9 4.7 17.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FHIPEP PF00771.20 CDI74788.1 - 8 4.8 8.2 12 4.3 8.2 1.3 1 0 0 1 1 1 0 FHIPEP family OATP PF03137.20 CDI74788.1 - 8 4.6 7.2 8.7 4.5 7.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Membralin PF09746.9 CDI74788.1 - 8.1 5.4 8.0 9.6 5.1 8.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein Peroxin-13_N PF04088.13 CDI74788.1 - 9.5 6.5 9.1 5 7.4 6.9 1.6 2 0 0 2 2 2 0 Peroxin 13, N-terminal region EIF4E-T PF10477.9 CDI74789.1 - 9.7e-06 24.7 9.6 9.7e-06 24.7 9.6 2.4 2 0 0 2 2 2 2 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E ABC_tran PF00005.27 CDI74790.1 - 1.1e-19 71.4 37.7 6.3e-11 42.9 34.5 6.5 5 2 0 5 5 3 2 ABC transporter AAA_21 PF13304.6 CDI74790.1 - 4.1e-16 59.7 0.0 0.00013 21.9 0.0 3.2 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDI74790.1 - 6.7e-11 42.0 18.4 1.3e-07 31.3 9.8 3.2 3 0 0 3 3 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDI74790.1 - 7.3e-09 35.2 0.0 0.0036 17.0 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain cobW PF02492.19 CDI74790.1 - 2.7e-06 27.1 0.1 0.052 13.1 0.0 3.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 CDI74790.1 - 1.2e-05 25.0 0.1 0.0059 16.2 0.4 3.2 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CDI74790.1 - 1.5e-05 25.0 0.0 0.073 13.2 0.0 3.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase RNA_helicase PF00910.22 CDI74790.1 - 2.2e-05 24.8 0.5 0.076 13.4 0.0 3.3 2 0 0 2 2 2 2 RNA helicase IstB_IS21 PF01695.17 CDI74790.1 - 0.0001 22.1 5.9 0.0022 17.8 1.2 4.4 5 0 0 5 5 3 2 IstB-like ATP binding protein AAA_7 PF12775.7 CDI74790.1 - 0.00011 21.7 8.8 0.016 14.7 0.9 3.3 3 0 0 3 3 3 2 P-loop containing dynein motor region NTPase_1 PF03266.15 CDI74790.1 - 0.0002 21.3 0.3 0.45 10.4 0.2 2.8 2 0 0 2 2 2 2 NTPase AAA_19 PF13245.6 CDI74790.1 - 0.00029 21.2 10.6 0.013 15.8 0.0 4.2 3 0 0 3 3 3 2 AAA domain SR-25 PF10500.9 CDI74790.1 - 0.00041 20.0 13.0 0.00041 20.0 13.0 6.6 6 2 1 7 7 5 1 Nuclear RNA-splicing-associated protein AAA_23 PF13476.6 CDI74790.1 - 0.0005 20.6 5.6 0.0074 16.8 0.2 8.8 7 2 2 9 9 6 3 AAA domain TsaE PF02367.17 CDI74790.1 - 0.00077 19.5 1.9 0.8 9.7 0.2 2.7 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 CDI74790.1 - 0.00092 19.0 3.7 0.16 11.7 0.1 2.9 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.14 CDI74790.1 - 0.001 19.1 8.7 0.54 10.3 0.0 4.1 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) T2SSE PF00437.20 CDI74790.1 - 0.0011 18.1 2.8 0.0011 18.1 2.8 3.9 3 1 1 4 4 3 2 Type II/IV secretion system protein Pox_A32 PF04665.12 CDI74790.1 - 0.0018 17.8 0.0 1.9 7.9 0.0 2.8 2 0 0 2 2 2 2 Poxvirus A32 protein RsgA_GTPase PF03193.16 CDI74790.1 - 0.0021 18.0 1.6 0.0021 18.0 1.6 4.7 5 1 0 5 5 4 2 RsgA GTPase ATPase_2 PF01637.18 CDI74790.1 - 0.0043 17.0 4.8 0.57 10.1 0.0 3.0 3 0 0 3 3 3 2 ATPase domain predominantly from Archaea Septin PF00735.18 CDI74790.1 - 0.0048 16.2 0.5 0.0048 16.2 0.5 5.2 4 1 1 5 5 4 2 Septin AAA_14 PF13173.6 CDI74790.1 - 0.0051 16.8 8.2 1.1 9.3 0.0 4.5 3 1 2 5 5 5 2 AAA domain AAA_22 PF13401.6 CDI74790.1 - 0.0078 16.5 0.0 0.0078 16.5 0.0 5.7 6 2 1 7 7 4 1 AAA domain AAA PF00004.29 CDI74790.1 - 0.0096 16.3 14.7 0.15 12.5 0.0 4.4 4 1 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CDI74790.1 - 0.0097 15.8 0.2 0.0097 15.8 0.2 5.6 4 1 0 4 4 4 2 NACHT domain Roc PF08477.13 CDI74790.1 - 0.03 14.6 0.2 0.03 14.6 0.2 5.5 6 0 0 6 6 4 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 CDI74790.1 - 0.061 13.9 0.3 0.061 13.9 0.3 4.9 5 2 0 5 5 3 0 AAA domain AAA_24 PF13479.6 CDI74790.1 - 0.098 12.4 0.2 0.098 12.4 0.2 5.0 4 1 1 5 5 3 0 AAA domain AAA_15 PF13175.6 CDI74790.1 - 0.11 12.2 0.1 0.11 12.2 0.1 5.6 3 2 0 4 4 1 0 AAA ATPase domain GTP_EFTU PF00009.27 CDI74790.1 - 0.21 11.1 0.0 0.073 12.6 2.2 5.0 4 2 1 5 5 3 0 Elongation factor Tu GTP binding domain PRK PF00485.18 CDI74790.1 - 0.26 11.0 11.4 1.2 8.8 1.7 3.1 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family MobB PF03205.14 CDI74790.1 - 0.64 9.9 11.5 1.7 8.6 0.1 4.1 3 2 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF3275 PF11679.8 CDI74792.1 - 0.05 13.6 2.9 0.065 13.2 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) DUF3381 PF11861.8 CDI74792.1 - 0.2 11.4 1.5 0.24 11.2 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF1180 PF06679.12 CDI74792.1 - 0.51 10.7 4.1 0.67 10.3 4.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) PAT1 PF09770.9 CDI74794.1 - 0.42 8.8 128.1 0.42 8.8 59.0 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Exonuc_VII_L PF02601.15 CDI74794.1 - 7.7 6.0 78.4 6.7 6.2 37.0 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit WD40 PF00400.32 CDI74795.1 - 6.6e-13 48.9 0.1 3.5e-08 34.0 0.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI74795.1 - 0.0055 17.0 0.0 0.054 13.8 0.0 2.2 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Lipase_3 PF01764.25 CDI74796.1 - 2.6e-18 66.3 0.0 5.2e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CDI74796.1 - 0.00024 21.8 1.3 0.00079 20.1 0.4 2.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDI74796.1 - 0.0078 15.5 0.2 0.036 13.3 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CDI74796.1 - 0.046 13.8 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 Thioesterase domain DUF676 PF05057.14 CDI74796.1 - 0.046 13.2 0.0 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 Putative serine esterase (DUF676) PGAP1 PF07819.13 CDI74796.1 - 0.17 11.5 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Pkinase PF00069.25 CDI74797.1 - 4.9e-40 137.6 0.0 6.7e-12 45.3 0.0 4.4 4 0 0 4 4 4 4 Protein kinase domain Pkinase_Tyr PF07714.17 CDI74797.1 - 8.3e-20 71.1 0.0 1.5e-12 47.4 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase EF-hand_1 PF00036.32 CDI74797.1 - 3.1e-08 32.6 0.0 0.0072 15.8 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 CDI74797.1 - 2.4e-07 31.1 0.0 0.063 13.7 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI74797.1 - 2.4e-06 27.0 0.2 0.13 12.2 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 CDI74797.1 - 3.7e-05 23.0 0.1 0.18 11.4 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDI74797.1 - 0.0023 17.8 0.1 0.15 11.9 0.1 3.0 3 0 0 3 3 3 1 EF-hand domain pair HIT PF01230.23 CDI74798.1 - 1.3e-14 54.7 2.1 4.2e-06 27.4 1.6 2.2 1 1 1 2 2 2 2 HIT domain DcpS_C PF11969.8 CDI74798.1 - 4.3e-06 27.2 1.4 0.0022 18.4 0.0 2.1 1 1 1 2 2 2 2 Scavenger mRNA decapping enzyme C-term binding AAA PF00004.29 CDI74800.1 - 2.3e-88 293.4 0.0 1.5e-46 158.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI74800.1 - 1.5e-25 88.7 8.1 1.3e-13 50.5 0.6 3.7 4 0 0 4 4 3 2 AAA+ lid domain CDC48_N PF02359.18 CDI74800.1 - 2.3e-21 75.8 0.8 5.2e-21 74.6 0.8 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain CDC48_2 PF02933.17 CDI74800.1 - 1.4e-09 37.6 0.0 3.4e-09 36.3 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_2 PF07724.14 CDI74800.1 - 3.9e-09 36.8 0.0 2.1e-06 27.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CDI74800.1 - 6.2e-09 35.8 0.0 5.2e-06 26.3 0.0 3.0 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDI74800.1 - 2.1e-07 31.5 0.4 0.00055 20.4 0.0 4.0 2 2 1 3 3 3 1 AAA ATPase domain AAA_33 PF13671.6 CDI74800.1 - 4.9e-07 30.0 0.0 5.7e-05 23.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain Vps4_C PF09336.10 CDI74800.1 - 1.1e-06 28.5 0.1 0.00056 19.9 0.0 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.14 CDI74800.1 - 1.8e-06 28.0 0.1 3.7e-05 23.7 0.0 3.0 2 2 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 CDI74800.1 - 2.2e-06 27.8 0.0 0.0019 18.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CDI74800.1 - 4.7e-06 26.9 0.2 0.075 13.3 0.0 3.8 2 2 2 4 4 4 1 AAA domain TIP49 PF06068.13 CDI74800.1 - 9.8e-05 21.7 0.1 0.00077 18.8 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_18 PF13238.6 CDI74800.1 - 0.00022 21.8 0.0 0.031 14.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain Cytidylate_kin2 PF13189.6 CDI74800.1 - 0.0016 18.6 0.0 2.4 8.3 0.0 2.6 2 0 0 2 2 2 2 Cytidylate kinase-like family AAA_25 PF13481.6 CDI74800.1 - 0.0031 17.1 2.0 1.4 8.5 0.1 3.3 3 1 1 4 4 4 1 AAA domain RNA_helicase PF00910.22 CDI74800.1 - 0.0037 17.6 0.0 0.38 11.2 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Viral_helicase1 PF01443.18 CDI74800.1 - 0.0057 16.4 0.0 0.61 9.8 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 CDI74800.1 - 0.0072 15.7 0.1 0.051 13.0 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 CDI74800.1 - 0.011 15.7 0.0 1.5 8.8 0.0 2.8 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 CDI74800.1 - 0.012 15.5 0.2 3.3 7.6 0.0 3.3 2 1 0 3 3 3 0 NACHT domain AAA_17 PF13207.6 CDI74800.1 - 0.031 14.7 0.0 0.18 12.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDI74800.1 - 0.033 14.4 0.0 0.47 10.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CDI74800.1 - 0.038 13.3 0.0 0.82 8.9 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin ATPase_2 PF01637.18 CDI74800.1 - 0.04 13.8 0.1 0.67 9.8 0.1 2.7 3 1 0 3 3 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 CDI74800.1 - 0.042 13.6 0.0 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_24 PF13479.6 CDI74800.1 - 0.044 13.5 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDI74800.1 - 0.048 13.0 1.1 3.5 6.9 0.1 2.6 3 0 0 3 3 2 0 KaiC KAP_NTPase PF07693.14 CDI74800.1 - 0.05 12.8 0.0 3.4 6.8 0.0 2.9 2 1 1 3 3 3 0 KAP family P-loop domain ABC_tran PF00005.27 CDI74800.1 - 0.057 13.9 0.0 1.7 9.2 0.0 2.8 2 1 0 2 2 2 0 ABC transporter Sigma54_activ_2 PF14532.6 CDI74800.1 - 0.072 13.2 0.0 0.62 10.2 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 CDI74800.1 - 0.079 12.7 0.0 1.4 8.6 0.0 2.9 2 1 0 2 2 2 0 Sigma-54 interaction domain ResIII PF04851.15 CDI74800.1 - 0.086 12.8 0.0 0.32 11.0 0.0 1.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SKI PF01202.22 CDI74800.1 - 0.095 12.8 0.3 23 5.1 0.0 2.9 3 0 0 3 3 3 0 Shikimate kinase UFD1 PF03152.14 CDI74800.1 - 0.13 11.7 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 AAA_7 PF12775.7 CDI74800.1 - 0.14 11.7 0.1 0.51 9.8 0.0 2.0 2 1 0 2 2 2 0 P-loop containing dynein motor region NB-ARC PF00931.22 CDI74800.1 - 0.14 11.3 0.1 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain Bac_DnaA PF00308.18 CDI74800.1 - 0.16 11.8 0.0 0.9 9.3 0.0 2.1 2 0 0 2 2 2 0 Bacterial dnaA protein PhoH PF02562.16 CDI74800.1 - 0.18 11.2 0.1 4.6 6.7 0.1 2.3 2 0 0 2 2 2 0 PhoH-like protein PGM_PMM_III PF02880.16 CDI74801.1 - 1.6e-26 92.7 0.0 4.3e-26 91.4 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_I PF02878.16 CDI74801.1 - 2.2e-26 92.2 0.0 3.9e-26 91.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 CDI74801.1 - 7.6e-10 39.3 0.0 3.6e-09 37.2 0.0 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CDI74801.1 - 0.00032 20.8 0.0 0.0014 18.8 0.0 2.1 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Striatin PF08232.12 CDI74802.1 - 0.11 13.1 8.5 0.13 12.9 8.5 1.2 1 0 0 1 1 1 0 Striatin family CobT PF06213.12 CDI74802.1 - 0.23 10.8 7.3 0.3 10.5 7.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RIFIN PF02009.16 CDI74802.1 - 0.67 9.8 5.9 0.83 9.5 5.9 1.1 1 0 0 1 1 1 0 Rifin FAM60A PF15396.6 CDI74802.1 - 0.84 9.6 10.4 0.98 9.4 10.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A AF-4 PF05110.13 CDI74802.1 - 0.98 7.4 32.9 1.1 7.3 32.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF1635 PF07795.11 CDI74802.1 - 1.1 9.1 17.1 1.9 8.3 17.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) SPX PF03105.19 CDI74802.1 - 1.3 8.9 25.5 1.5 8.7 25.5 1.0 1 0 0 1 1 1 0 SPX domain Lin-8 PF03353.15 CDI74802.1 - 1.3 8.5 14.4 1.5 8.3 14.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MAT1 PF06391.13 CDI74802.1 - 1.3 8.8 6.5 1.4 8.7 6.5 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Apt1 PF10351.9 CDI74802.1 - 2.2 7.0 21.9 2.5 6.9 21.9 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Miga PF10265.9 CDI74802.1 - 3.2 6.6 17.3 3.7 6.4 17.3 1.0 1 0 0 1 1 1 0 Mitoguardin TFIIA PF03153.13 CDI74802.1 - 3.3 7.6 16.3 4 7.3 16.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GEMIN8 PF15348.6 CDI74802.1 - 3.4 7.9 13.3 3.8 7.7 13.3 1.1 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 NPR3 PF03666.13 CDI74802.1 - 4.1 6.1 16.4 4.8 5.9 16.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Band_3_cyto PF07565.13 CDI74802.1 - 4.1 7.1 8.1 4.8 6.9 8.1 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SARAF PF06682.12 CDI74802.1 - 4.2 6.9 15.6 4.8 6.7 15.6 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis SKA1 PF07160.12 CDI74802.1 - 4.2 7.2 8.7 4.9 6.9 8.7 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 ASD2 PF08687.11 CDI74802.1 - 4.4 6.8 9.2 5.1 6.6 9.2 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 SLC12 PF03522.15 CDI74802.1 - 4.5 6.2 11.6 4.9 6.1 11.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 HSD3 PF15244.6 CDI74802.1 - 4.6 6.6 19.2 5.2 6.5 19.2 1.0 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 FAM76 PF16046.5 CDI74802.1 - 4.7 6.5 13.5 5.7 6.2 13.5 1.1 1 0 0 1 1 1 0 FAM76 protein DUF4179 PF13786.6 CDI74802.1 - 4.9 7.7 9.1 11 6.6 9.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) Hid1 PF12722.7 CDI74802.1 - 5.5 5.0 13.0 5.9 4.9 13.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2464 PF10240.9 CDI74802.1 - 5.6 6.5 10.4 7.4 6.1 10.4 1.3 1 0 0 1 1 1 0 Multivesicular body subunit 12 Menin PF05053.13 CDI74802.1 - 5.6 5.2 19.1 7.7 4.7 19.1 1.2 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 CDI74802.1 - 7 5.3 18.1 8 5.1 18.1 1.1 1 0 0 1 1 1 0 Presenilin PNISR PF15996.5 CDI74802.1 - 8.8 6.6 11.4 11 6.3 11.4 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR ALMT PF11744.8 CDI74802.1 - 8.9 5.0 11.1 9.7 4.9 11.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter AAA_23 PF13476.6 CDI74803.1 - 0.022 15.3 19.0 0.015 15.8 14.0 2.1 2 0 0 2 2 2 0 AAA domain FA_hydroxylase PF04116.13 CDI74803.1 - 0.77 10.1 6.2 0.12 12.7 1.2 2.0 1 1 1 2 2 2 0 Fatty acid hydroxylase superfamily Macoilin PF09726.9 CDI74804.1 - 0.0077 14.8 10.7 0.011 14.4 10.7 1.1 1 0 0 1 1 1 1 Macoilin family Na_trans_assoc PF06512.13 CDI74804.1 - 0.021 15.1 10.4 0.037 14.3 10.4 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated PIP5K PF01504.18 CDI74804.1 - 0.11 11.6 9.5 10 5.2 12.2 2.0 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase SLC12 PF03522.15 CDI74804.1 - 0.24 10.4 18.0 0.33 9.9 18.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF3402 PF11882.8 CDI74804.1 - 0.95 8.5 17.5 0.27 10.3 12.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3402) Connexin PF00029.19 CDI74804.1 - 1 9.1 13.4 0.07 12.9 7.4 1.8 2 0 0 2 2 2 0 Connexin SPX PF03105.19 CDI74804.1 - 1.5 8.7 16.3 2.3 8.1 16.3 1.2 1 0 0 1 1 1 0 SPX domain CCDC53 PF10152.9 CDI74804.1 - 2.1 8.7 20.0 0.22 11.9 11.5 2.5 3 0 0 3 3 2 0 Subunit CCDC53 of WASH complex FAM76 PF16046.5 CDI74804.1 - 2.2 7.6 23.1 3.3 7.0 23.1 1.1 1 0 0 1 1 1 0 FAM76 protein Hid1 PF12722.7 CDI74804.1 - 2.3 6.2 13.9 3.4 5.7 13.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Folate_carrier PF01770.18 CDI74804.1 - 2.6 6.7 10.9 0.038 12.7 3.9 1.5 2 0 0 2 2 2 0 Reduced folate carrier SID-1_RNA_chan PF13965.6 CDI74804.1 - 3 6.2 8.2 0.11 10.9 2.6 1.3 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Peptidase_S49_N PF08496.10 CDI74804.1 - 3.7 7.6 16.7 1.1 9.4 9.5 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal CLN3 PF02487.17 CDI74804.1 - 3.7 6.5 14.4 0.11 11.5 7.4 1.8 2 0 0 2 2 2 0 CLN3 protein FAM176 PF14851.6 CDI74804.1 - 5.5 6.6 8.5 0.72 9.5 3.3 2.0 2 0 0 2 2 2 0 FAM176 family VAD1-2 PF15310.6 CDI74804.1 - 6.1 6.6 27.0 9.9 5.9 27.0 1.2 1 0 0 1 1 1 0 Vitamin A-deficiency (VAD) rat model signalling RIFIN PF02009.16 CDI74805.1 - 0.0018 18.2 6.4 0.0018 18.2 6.4 8.0 5 2 2 7 7 7 2 Rifin MACPF PF01823.19 CDI74805.1 - 0.0098 16.0 0.1 0.0098 16.0 0.1 9.4 6 1 6 12 12 12 1 MAC/Perforin domain SUIM_assoc PF16619.5 CDI74805.1 - 0.081 13.0 0.0 0.081 13.0 0.0 12.0 8 3 3 11 11 11 0 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI74806.1 - 0.0031 17.8 3.2 0.0031 17.8 3.2 13.3 2 2 9 11 11 11 3 Anti-sigma-K factor rskA TMEM144 PF07857.12 CDI74806.1 - 0.53 9.2 1.6 2.2 7.2 1.6 2.1 1 0 0 1 1 1 0 Transmembrane family, TMEM144 of transporters Peptidase_S49_N PF08496.10 CDI74807.1 - 0.00066 19.8 2.5 0.00077 19.6 2.5 1.0 1 0 0 1 1 1 1 Peptidase family S49 N-terminal DEC-1_N PF04625.13 CDI74807.1 - 0.0069 15.5 10.2 0.0085 15.2 10.2 1.1 1 0 0 1 1 1 1 DEC-1 protein, N-terminal region Ctr PF04145.15 CDI74807.1 - 0.014 16.1 1.0 0.016 15.8 1.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family R_equi_Vir PF05526.11 CDI74807.1 - 0.19 11.5 7.0 0.25 11.2 7.0 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein TFIIA PF03153.13 CDI74807.1 - 0.2 11.6 18.3 0.2 11.6 18.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI74807.1 - 0.37 10.4 21.8 0.4 10.3 21.8 1.1 1 0 0 1 1 1 0 Spt20 family Serinc PF03348.15 CDI74807.1 - 0.38 9.6 2.9 0.39 9.6 2.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) RskA PF10099.9 CDI74807.1 - 1.1 9.5 25.1 31 4.8 25.1 2.0 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI74807.1 - 3.5 8.7 10.8 4.7 8.3 10.8 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) RskA PF10099.9 CDI74808.1 - 0.0055 17.0 0.1 0.0055 17.0 0.1 2.4 1 1 1 2 2 2 1 Anti-sigma-K factor rskA PPP4R2 PF09184.11 CDI74808.1 - 0.61 9.6 14.5 0.73 9.4 14.5 1.2 1 0 0 1 1 1 0 PPP4R2 DUF572 PF04502.13 CDI74808.1 - 1.3 8.5 16.1 1.8 8.1 16.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) SOBP PF15279.6 CDI74808.1 - 3.4 8.2 20.1 4.3 7.8 20.1 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Sporozoite_P67 PF05642.11 CDI74809.1 - 0.42 8.6 5.1 0.62 8.1 5.1 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pkinase PF00069.25 CDI74810.1 - 4.7e-06 26.2 4.7 4.8e-06 26.1 0.0 2.8 3 0 0 3 3 3 1 Protein kinase domain RskA PF10099.9 CDI74810.1 - 1.7e-05 25.2 19.6 1.7e-05 25.2 19.6 4.9 2 2 0 3 3 3 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI74810.1 - 0.0015 18.2 16.9 0.0015 18.2 16.9 3.6 2 1 0 2 2 2 1 Spt20 family Apt1 PF10351.9 CDI74810.1 - 0.11 11.4 34.8 0.36 9.6 18.8 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain eIF-3_zeta PF05091.12 CDI74810.1 - 1.4 7.8 29.0 0.6 9.0 6.6 2.7 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_S64 PF08192.11 CDI74810.1 - 5.8 5.3 38.1 1.8 6.9 20.8 2.2 2 0 0 2 2 2 0 Peptidase family S64 DUF4179 PF13786.6 CDI74810.1 - 7.6 7.1 0.0 7.1 7.2 0.0 4.6 4 1 1 5 5 5 0 Domain of unknown function (DUF4179) Utp14 PF04615.13 CDI74811.1 - 1.1e-06 27.6 6.2 1.1e-06 27.6 6.2 6.2 4 1 1 6 6 6 3 Utp14 protein RskA PF10099.9 CDI74811.1 - 1.7e-05 25.2 20.0 0.00049 20.4 10.1 13.7 4 3 5 10 10 10 5 Anti-sigma-K factor rskA Transposase_21 PF02992.14 CDI74811.1 - 0.1 11.8 1.9 0.24 10.6 1.9 1.6 1 0 0 1 1 1 0 Transposase family tnp2 RskA PF10099.9 CDI74812.1 - 3.7e-06 27.4 20.2 0.0001 22.7 0.0 2.7 2 1 0 2 2 2 2 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI74812.1 - 8.1e-06 25.6 10.4 8.1e-06 25.6 10.4 4.2 3 1 0 4 4 4 1 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI74812.1 - 0.005 15.9 12.6 0.005 15.9 12.6 3.4 3 1 0 3 3 3 2 Protein of unknown function (DUF2722) MecA PF05389.12 CDI74812.1 - 1.5 8.4 9.8 0.74 9.4 0.9 2.4 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) Sec62 PF03839.16 CDI74812.1 - 9.5 5.7 7.3 11 5.5 0.6 2.4 2 0 0 2 2 2 0 Translocation protein Sec62 DUF4407 PF14362.6 CDI74813.1 - 0.028 13.8 11.8 0.033 13.6 11.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SpoIIP PF07454.11 CDI74813.1 - 0.039 13.4 8.4 0.037 13.5 8.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PRC2_HTH_1 PF18118.1 CDI74813.1 - 0.044 14.6 5.7 0.062 14.1 5.7 1.3 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain DUF4746 PF15928.5 CDI74813.1 - 0.049 13.0 2.6 0.044 13.2 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF2722 PF10846.8 CDI74813.1 - 0.055 12.4 26.7 0.057 12.4 26.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DDHD PF02862.17 CDI74813.1 - 0.063 13.4 6.4 0.068 13.3 6.4 1.1 1 0 0 1 1 1 0 DDHD domain Connexin PF00029.19 CDI74813.1 - 0.071 12.9 5.7 0.086 12.6 5.7 1.1 1 0 0 1 1 1 0 Connexin MecA PF05389.12 CDI74813.1 - 0.13 11.9 7.4 0.13 11.8 7.4 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF2347 PF09804.9 CDI74813.1 - 0.14 11.7 6.7 0.19 11.3 6.7 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Zip PF02535.22 CDI74813.1 - 0.15 11.2 2.0 0.16 11.1 2.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Suf PF05843.14 CDI74813.1 - 0.17 11.8 14.7 0.17 11.9 14.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Maf1 PF09174.10 CDI74813.1 - 0.17 12.0 4.7 0.21 11.8 4.7 1.1 1 0 0 1 1 1 0 Maf1 regulator Gti1_Pac2 PF09729.9 CDI74813.1 - 0.21 11.7 5.7 0.22 11.6 5.7 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Tim54 PF11711.8 CDI74813.1 - 0.28 9.9 8.1 0.3 9.8 8.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF5523 PF17661.1 CDI74813.1 - 0.28 10.8 13.3 0.41 10.3 13.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Scs3p PF10261.9 CDI74813.1 - 0.29 10.6 2.4 0.33 10.4 2.4 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Cyclin PF08613.11 CDI74813.1 - 0.33 11.3 2.2 0.35 11.2 2.2 1.1 1 0 0 1 1 1 0 Cyclin DUF2126 PF09899.9 CDI74813.1 - 0.37 8.8 6.5 0.36 8.8 6.5 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) EPL1 PF10513.9 CDI74813.1 - 0.39 11.1 10.8 0.44 10.9 10.8 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF4824 PF16106.5 CDI74813.1 - 0.42 9.8 11.8 0.44 9.8 11.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4824) OATP PF03137.20 CDI74813.1 - 0.43 8.8 4.6 0.5 8.6 4.6 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Ndc1_Nup PF09531.10 CDI74813.1 - 0.7 8.5 9.3 0.73 8.5 9.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DNApol_Exo PF18136.1 CDI74813.1 - 0.71 9.0 8.7 0.75 8.9 8.7 1.2 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain MDM10 PF12519.8 CDI74813.1 - 0.88 8.4 7.0 0.85 8.4 7.0 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Dynactin_p62 PF05502.13 CDI74813.1 - 1.1 8.0 12.1 1.4 7.7 12.1 1.1 1 0 0 1 1 1 0 Dynactin p62 family SID-1_RNA_chan PF13965.6 CDI74813.1 - 1.2 7.5 4.8 1.1 7.6 4.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TFIIA PF03153.13 CDI74813.1 - 1.5 8.7 36.7 1.7 8.5 36.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FHIPEP PF00771.20 CDI74813.1 - 1.6 7.1 11.5 2.2 6.7 11.5 1.2 1 0 0 1 1 1 0 FHIPEP family ALMT PF11744.8 CDI74813.1 - 1.6 7.4 6.7 1.4 7.6 6.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CSG2 PF16965.5 CDI74813.1 - 1.7 7.5 4.8 1.9 7.3 4.8 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator CPSF100_C PF13299.6 CDI74813.1 - 1.7 8.8 10.1 2.2 8.4 10.1 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal PepSY_TM PF03929.16 CDI74813.1 - 2.1 8.0 6.3 2.1 8.0 6.3 1.1 1 0 0 1 1 1 0 PepSY-associated TM region CLN3 PF02487.17 CDI74813.1 - 2.1 7.3 8.5 2 7.4 8.5 1.1 1 0 0 1 1 1 0 CLN3 protein RR_TM4-6 PF06459.12 CDI74813.1 - 2.1 8.1 10.8 2.5 7.8 10.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobT PF06213.12 CDI74813.1 - 3.5 6.9 17.3 4.5 6.6 17.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT EOS1 PF12326.8 CDI74813.1 - 4.5 7.2 5.7 6.6 6.6 5.7 1.4 1 0 0 1 1 1 0 N-glycosylation protein Paramyxo_ncap PF00973.19 CDI74813.1 - 5.6 5.8 6.8 4.9 6.0 6.8 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein TERB2 PF15101.6 CDI74813.1 - 5.8 6.9 19.2 7.7 6.5 19.2 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 eIF-3_zeta PF05091.12 CDI74813.1 - 7.8 5.4 17.6 8 5.3 17.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3464 PF11947.8 CDI74813.1 - 9.4 6.0 14.0 12 5.6 14.0 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 TFIIA PF03153.13 CDI74814.1 - 0.015 15.4 35.4 0.017 15.2 35.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MAP65_ASE1 PF03999.12 CDI74814.1 - 0.12 11.1 26.8 0.14 10.9 26.8 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) ATP11 PF06644.11 CDI74814.1 - 0.13 12.1 18.6 0.2 11.4 18.6 1.3 1 0 0 1 1 1 0 ATP11 protein MDM1 PF15501.6 CDI74814.1 - 0.24 10.5 29.6 0.29 10.3 29.6 1.0 1 0 0 1 1 1 0 Nuclear protein MDM1 GREB1 PF15782.5 CDI74814.1 - 0.38 7.8 25.8 0.38 7.8 25.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer BAT2_N PF07001.11 CDI74814.1 - 0.42 11.0 27.7 0.55 10.7 27.7 1.3 1 0 0 1 1 1 0 BAT2 N-terminus DUF4647 PF15504.6 CDI74814.1 - 0.54 9.3 20.0 0.61 9.1 20.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Macoilin PF09726.9 CDI74814.1 - 0.67 8.5 27.5 0.7 8.4 27.5 1.0 1 0 0 1 1 1 0 Macoilin family TAF4 PF05236.14 CDI74814.1 - 0.68 9.6 20.7 0.82 9.4 20.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DUF4746 PF15928.5 CDI74814.1 - 0.7 9.3 9.2 0.8 9.1 9.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4638 PF15472.6 CDI74814.1 - 0.96 9.1 15.4 1.1 8.9 15.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Peptidase_S64 PF08192.11 CDI74814.1 - 1.2 7.5 26.3 1.2 7.5 26.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 CCSAP PF15748.5 CDI74814.1 - 1.4 9.0 27.3 1.6 8.8 27.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PepSY_TM PF03929.16 CDI74814.1 - 1.7 8.3 6.8 1.8 8.2 6.8 1.2 1 0 0 1 1 1 0 PepSY-associated TM region SPX PF03105.19 CDI74814.1 - 2.1 8.2 27.9 2.2 8.1 27.9 1.0 1 0 0 1 1 1 0 SPX domain Presenilin PF01080.17 CDI74814.1 - 2.4 6.9 27.2 2.5 6.8 27.2 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI74814.1 - 2.4 7.1 22.3 2.5 7.0 22.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Draxin PF15550.6 CDI74814.1 - 2.5 7.9 16.1 2.6 7.8 16.1 1.0 1 0 0 1 1 1 0 Draxin eIF-3_zeta PF05091.12 CDI74814.1 - 2.6 6.9 22.2 2.9 6.8 22.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4175 PF13779.6 CDI74814.1 - 2.8 5.8 25.2 2.8 5.7 25.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PAT1 PF09770.9 CDI74814.1 - 3.1 6.0 28.8 3.1 6.0 28.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Plasmodium_Vir PF05795.11 CDI74814.1 - 3.2 7.1 20.1 3.8 6.8 20.1 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Kinesin_assoc PF16183.5 CDI74814.1 - 3.8 7.6 9.5 5 7.2 9.5 1.2 1 0 0 1 1 1 0 Kinesin-associated Apt1 PF10351.9 CDI74814.1 - 4.7 6.0 26.3 5.1 5.8 26.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 CDI74814.1 - 4.8 6.7 29.5 5.5 6.5 29.5 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Membralin PF09746.9 CDI74814.1 - 5.2 6.0 13.8 6 5.8 13.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein Borrelia_P83 PF05262.11 CDI74814.1 - 6.1 5.2 19.4 6.4 5.1 19.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein PNISR PF15996.5 CDI74814.1 - 6.3 7.0 25.7 8 6.7 25.7 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF4551 PF15087.6 CDI74814.1 - 6.4 5.5 22.4 6.6 5.4 22.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SRP-alpha_N PF04086.13 CDI74814.1 - 7 6.5 24.7 7.7 6.3 24.7 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF4407 PF14362.6 CDI74814.1 - 7.5 5.8 16.1 8.1 5.7 16.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FAM60A PF15396.6 CDI74814.1 - 8.9 6.3 20.1 12 5.8 20.1 1.2 1 0 0 1 1 1 0 Protein Family FAM60A TssO PF17561.2 CDI74815.1 - 0.0069 16.5 8.0 0.012 15.7 8.0 1.4 1 0 0 1 1 1 1 Type VI secretion system, TssO DUF4834 PF16118.5 CDI74815.1 - 0.019 15.9 4.7 0.019 15.9 4.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 CDI74815.1 - 0.023 13.5 7.9 0.033 13.0 7.9 1.2 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 CDI74815.1 - 0.084 11.9 0.1 0.084 11.9 0.1 1.4 2 0 0 2 2 2 0 CLN3 protein FHIPEP PF00771.20 CDI74815.1 - 0.15 10.5 1.4 0.2 10.1 1.4 1.1 1 0 0 1 1 1 0 FHIPEP family Connexin PF00029.19 CDI74815.1 - 0.19 11.4 2.4 0.33 10.7 2.4 1.3 1 0 0 1 1 1 0 Connexin ALG3 PF05208.13 CDI74815.1 - 0.23 10.8 1.0 0.28 10.5 1.0 1.1 1 0 0 1 1 1 0 ALG3 protein Hid1 PF12722.7 CDI74815.1 - 0.29 9.2 7.9 0.37 8.9 7.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Folate_carrier PF01770.18 CDI74815.1 - 0.33 9.7 3.3 0.45 9.2 3.3 1.2 1 0 0 1 1 1 0 Reduced folate carrier TMEM208_SND2 PF05620.11 CDI74815.1 - 0.64 9.8 5.8 1.1 9.0 5.8 1.3 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 MAP17 PF15807.5 CDI74815.1 - 1.1 9.5 7.2 0.089 13.0 1.5 1.8 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SID-1_RNA_chan PF13965.6 CDI74815.1 - 1.2 7.5 3.8 0.37 9.1 0.7 1.6 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 EphA2_TM PF14575.6 CDI74815.1 - 2.8 8.9 4.9 2.6 9.0 1.6 2.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SHR3_chaperone PF08229.11 CDI74815.1 - 4 6.4 7.9 5.6 5.9 7.9 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 Transglut_core PF01841.19 CDI74817.1 - 0.00096 19.6 0.1 0.00096 19.6 0.1 5.1 5 1 1 6 6 6 1 Transglutaminase-like superfamily SUIM_assoc PF16619.5 CDI74817.1 - 0.0036 17.3 2.9 0.0036 17.3 2.9 16.0 12 4 2 14 14 14 2 Unstructured region C-term to UIM in Ataxin3 Rad4 PF03835.15 CDI74817.1 - 0.006 16.3 9.3 0.006 16.3 9.3 7.2 7 2 0 7 7 7 2 Rad4 transglutaminase-like domain Ribosomal_60s PF00428.19 CDI74817.1 - 0.0069 17.0 6.0 0.0069 17.0 6.0 21.6 13 7 5 19 19 19 2 60s Acidic ribosomal protein Spt20 PF12090.8 CDI74818.1 - 1.6e-06 27.9 40.1 0.0001 22.0 9.8 12.3 8 3 2 10 10 10 3 Spt20 family RAP PF08373.10 CDI74818.1 - 1e-05 25.6 0.0 2.2e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 RAP domain DUF2722 PF10846.8 CDI74818.1 - 0.0021 17.1 5.1 0.0021 17.1 5.1 13.1 10 3 2 12 12 12 4 Protein of unknown function (DUF2722) DUF3381 PF11861.8 CDI74818.1 - 0.018 14.9 0.4 0.018 14.9 0.4 9.8 6 2 0 6 6 6 0 Domain of unknown function (DUF3381) RPAP1_C PF08620.10 CDI74819.1 - 2e-16 59.8 0.0 9.3e-16 57.7 0.0 2.3 1 1 0 1 1 1 1 RPAP1-like, C-terminal DUF2722 PF10846.8 CDI74819.1 - 0.00048 19.2 10.0 0.00048 19.2 10.0 15.9 12 4 3 15 15 15 6 Protein of unknown function (DUF2722) TMEM51 PF15345.6 CDI74820.1 - 0.0045 16.9 5.9 0.0049 16.7 5.9 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 Tau95_N PF17682.1 CDI74820.1 - 0.033 14.4 2.2 0.035 14.3 2.2 1.1 1 0 0 1 1 1 0 Tau95 Triple barrel domain 2HCT PF03390.15 CDI74820.1 - 0.039 12.6 1.8 0.041 12.5 1.8 1.0 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family DUF4820 PF16091.5 CDI74820.1 - 0.069 12.5 6.0 0.069 12.5 6.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Pex14_N PF04695.13 CDI74820.1 - 0.1 13.3 13.1 0.11 13.2 13.1 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Connexin PF00029.19 CDI74820.1 - 0.12 12.2 3.2 0.12 12.1 3.2 1.0 1 0 0 1 1 1 0 Connexin DUF4834 PF16118.5 CDI74820.1 - 0.12 13.4 7.3 0.13 13.2 7.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) API5 PF05918.11 CDI74820.1 - 0.12 11.2 9.3 0.13 11.1 9.3 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) eIF-3_zeta PF05091.12 CDI74820.1 - 0.22 10.5 9.3 0.22 10.5 9.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spt20 PF12090.8 CDI74820.1 - 0.23 11.1 24.2 0.25 10.9 24.2 1.0 1 0 0 1 1 1 0 Spt20 family Orf78 PF06024.12 CDI74820.1 - 0.24 11.7 3.5 0.28 11.5 3.5 1.1 1 0 0 1 1 1 0 Orf78 (ac78) PA26 PF04636.13 CDI74820.1 - 0.27 10.1 6.4 0.27 10.1 6.4 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF702 PF05142.12 CDI74820.1 - 0.29 11.6 11.9 0.36 11.3 11.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Coilin_N PF15862.5 CDI74820.1 - 0.3 10.9 8.7 0.36 10.6 8.7 1.2 1 0 0 1 1 1 0 Coilin N-terminus Peptidase_S49_N PF08496.10 CDI74820.1 - 0.3 11.1 6.9 0.36 10.9 6.9 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal OsmC PF02566.19 CDI74820.1 - 0.31 11.6 3.0 0.46 11.0 3.0 1.3 1 1 0 1 1 1 0 OsmC-like protein Folate_carrier PF01770.18 CDI74820.1 - 0.31 9.7 3.6 0.33 9.6 3.6 1.0 1 0 0 1 1 1 0 Reduced folate carrier RskA PF10099.9 CDI74820.1 - 0.34 11.2 17.2 5.4 7.3 17.6 1.9 1 1 0 1 1 1 0 Anti-sigma-K factor rskA EIIBC-GUT_N PF03612.14 CDI74820.1 - 0.43 10.3 5.9 0.45 10.2 5.9 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TERB2 PF15101.6 CDI74820.1 - 0.46 10.5 11.2 0.49 10.4 11.2 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 NEMP PF10225.9 CDI74820.1 - 0.47 10.1 3.1 0.53 9.9 3.1 1.0 1 0 0 1 1 1 0 NEMP family Neur_chan_memb PF02932.16 CDI74820.1 - 0.47 10.5 5.1 0.48 10.5 5.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SID-1_RNA_chan PF13965.6 CDI74820.1 - 0.48 8.8 2.6 0.52 8.7 2.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CLN3 PF02487.17 CDI74820.1 - 0.57 9.2 5.9 0.64 9.0 5.9 1.0 1 0 0 1 1 1 0 CLN3 protein TFIIA PF03153.13 CDI74820.1 - 0.65 9.9 22.4 0.68 9.9 22.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Serinc PF03348.15 CDI74820.1 - 0.66 8.8 5.5 0.67 8.8 5.5 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF719 PF05334.13 CDI74820.1 - 0.82 9.8 10.7 0.94 9.6 10.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF719) Agouti PF05039.12 CDI74820.1 - 0.82 10.4 6.5 0.97 10.2 6.5 1.1 1 0 0 1 1 1 0 Agouti protein Ureide_permease PF07168.11 CDI74820.1 - 0.88 8.3 4.6 0.92 8.2 4.6 1.1 1 0 0 1 1 1 0 Ureide permease DUF2722 PF10846.8 CDI74820.1 - 1 8.3 19.8 1.1 8.1 19.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) EPL1 PF10513.9 CDI74820.1 - 1.1 9.6 9.9 1.3 9.4 9.9 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like CPSF100_C PF13299.6 CDI74820.1 - 1.4 9.1 8.9 1.5 8.9 8.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Roughex PF06020.11 CDI74820.1 - 1.5 7.8 9.8 1.6 7.7 9.8 1.1 1 0 0 1 1 1 0 Drosophila roughex protein AIF_C PF14721.6 CDI74820.1 - 1.6 9.1 7.4 1.9 8.8 7.4 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Presenilin PF01080.17 CDI74820.1 - 2 7.1 10.9 2.1 7.0 10.9 1.1 1 0 0 1 1 1 0 Presenilin CSG2 PF16965.5 CDI74820.1 - 2.1 7.2 4.4 2.1 7.2 4.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator UPF0560 PF10577.9 CDI74820.1 - 2.2 6.7 12.2 2.2 6.7 12.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Ctr PF04145.15 CDI74820.1 - 3.4 8.3 5.0 3.4 8.3 5.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family DDHD PF02862.17 CDI74820.1 - 3.4 7.8 10.5 3.6 7.7 10.5 1.0 1 0 0 1 1 1 0 DDHD domain FAM199X PF15814.5 CDI74820.1 - 6.8 5.7 9.9 7.4 5.5 9.9 1.1 1 0 0 1 1 1 0 Protein family FAM199X DivIC PF04977.15 CDI74820.1 - 7.4 6.4 14.8 10 6.0 14.8 1.2 1 0 0 1 1 1 0 Septum formation initiator Activator_LAG-3 PF11498.8 CDI74820.1 - 9.4 5.1 26.2 10 5.0 26.2 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF5383 PF17355.2 CDI74821.1 - 0.0041 17.5 3.3 0.005 17.2 3.3 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5383) DcuA_DcuB PF03605.14 CDI74821.1 - 0.005 15.8 0.9 0.0057 15.6 0.9 1.0 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter DUF4366 PF14283.6 CDI74821.1 - 0.0057 16.7 0.3 0.0059 16.7 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) ORC5_C PF14630.6 CDI74821.1 - 0.015 14.8 6.4 0.017 14.6 6.4 1.0 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus Peroxin-13_N PF04088.13 CDI74821.1 - 0.021 15.1 1.9 0.025 14.8 1.9 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Consortin_C PF15281.6 CDI74821.1 - 0.024 14.6 1.3 0.031 14.3 1.3 1.2 1 0 0 1 1 1 0 Consortin C-terminus PIP5K PF01504.18 CDI74821.1 - 0.03 13.6 4.1 0.031 13.5 4.1 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF3506 PF12014.8 CDI74821.1 - 0.031 14.3 1.3 0.036 14.1 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3506) DUF3464 PF11947.8 CDI74821.1 - 0.037 13.8 3.9 0.043 13.6 3.9 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF2031 PF09592.10 CDI74821.1 - 0.039 13.5 3.1 0.043 13.3 3.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) Orf78 PF06024.12 CDI74821.1 - 0.039 14.2 4.5 0.078 13.3 4.5 1.5 1 1 0 1 1 1 0 Orf78 (ac78) Presenilin PF01080.17 CDI74821.1 - 0.044 12.5 5.5 0.046 12.5 5.5 1.2 1 0 0 1 1 1 0 Presenilin RP-C_C PF11800.8 CDI74821.1 - 0.063 13.4 6.2 0.067 13.3 6.2 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region DDHD PF02862.17 CDI74821.1 - 0.075 13.2 4.3 0.073 13.2 4.3 1.1 1 0 0 1 1 1 0 DDHD domain Renin_r PF07850.14 CDI74821.1 - 0.091 13.4 0.2 0.12 13.0 0.2 1.3 1 0 0 1 1 1 0 Renin receptor-like protein Connexin PF00029.19 CDI74821.1 - 0.098 12.4 5.7 0.11 12.2 5.7 1.1 1 0 0 1 1 1 0 Connexin Ctr PF04145.15 CDI74821.1 - 0.14 12.8 6.4 0.14 12.8 6.4 1.0 1 0 0 1 1 1 0 Ctr copper transporter family CPSF100_C PF13299.6 CDI74821.1 - 0.14 12.3 6.3 0.17 12.1 6.3 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal HCO3_cotransp PF00955.21 CDI74821.1 - 0.15 10.9 3.4 0.15 10.8 3.4 1.0 1 0 0 1 1 1 0 HCO3- transporter family Pex14_N PF04695.13 CDI74821.1 - 0.18 12.5 12.8 0.2 12.3 12.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3292 PF11696.8 CDI74821.1 - 0.19 10.1 4.6 0.19 10.1 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF5305 PF17231.2 CDI74821.1 - 0.2 11.0 0.0 0.22 10.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF2207 PF09972.9 CDI74821.1 - 0.2 10.3 0.1 0.22 10.3 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) CD20 PF04103.15 CDI74821.1 - 0.27 11.3 1.5 0.31 11.1 1.5 1.1 1 0 0 1 1 1 0 CD20-like family Serinc PF03348.15 CDI74821.1 - 0.27 10.1 2.3 0.27 10.1 2.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) CLN3 PF02487.17 CDI74821.1 - 0.28 10.2 7.8 0.3 10.1 7.8 1.0 1 0 0 1 1 1 0 CLN3 protein DUF2232 PF09991.9 CDI74821.1 - 0.4 9.8 4.3 0.46 9.6 4.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DUF3984 PF13136.6 CDI74821.1 - 0.49 9.8 11.0 0.51 9.7 11.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) DUF4407 PF14362.6 CDI74821.1 - 0.61 9.4 10.8 0.73 9.1 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TraG_N PF07916.11 CDI74821.1 - 0.82 8.5 5.4 0.87 8.4 5.4 1.0 1 0 0 1 1 1 0 TraG-like protein, N-terminal region CSG2 PF16965.5 CDI74821.1 - 0.89 8.4 4.8 0.91 8.4 4.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Hydin_ADK PF17213.3 CDI74821.1 - 0.97 9.7 7.3 1.1 9.5 7.3 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain EIIBC-GUT_N PF03612.14 CDI74821.1 - 1 9.1 5.8 1.2 8.9 5.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Neur_chan_memb PF02932.16 CDI74821.1 - 1.1 9.3 6.0 1.2 9.1 6.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region OATP PF03137.20 CDI74821.1 - 1.2 7.3 4.0 1.3 7.2 4.0 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family ALMT PF11744.8 CDI74821.1 - 1.6 7.5 6.6 1.6 7.5 6.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4175 PF13779.6 CDI74821.1 - 2.3 6.0 24.3 2.3 6.0 24.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Paramyxo_ncap PF00973.19 CDI74821.1 - 2.3 7.1 5.6 2.4 7.0 5.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PigN PF04987.14 CDI74821.1 - 2.6 6.8 6.5 3 6.6 6.5 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Zip PF02535.22 CDI74821.1 - 2.6 7.2 6.3 2.8 7.1 6.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter LMBR1 PF04791.16 CDI74821.1 - 4 6.2 6.5 4.5 6.1 6.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Sec16 PF12932.7 CDI74821.1 - 4 8.0 7.6 9.2 6.9 7.6 1.7 1 1 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region TFIIA PF03153.13 CDI74821.1 - 4.2 7.3 31.0 4.2 7.3 31.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit 60KD_IMP PF02096.20 CDI74821.1 - 4.9 7.0 19.7 7.8 6.4 19.7 1.4 1 1 0 1 1 1 0 60Kd inner membrane protein BatA PF07584.11 CDI74821.1 - 5.4 7.4 8.2 14 6.1 8.2 1.9 1 1 0 1 1 1 0 Aerotolerance regulator N-terminal PAT1 PF09770.9 CDI74821.1 - 7.6 4.7 20.5 7.9 4.6 20.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 IPK PF03770.16 CDI74822.1 - 5.5e-10 39.4 0.0 5.5e-10 39.4 0.0 2.5 2 1 0 2 2 2 1 Inositol polyphosphate kinase MDM1 PF15501.6 CDI74822.1 - 0.76 8.9 22.5 0.54 9.4 4.3 2.1 2 0 0 2 2 2 0 Nuclear protein MDM1 Ureide_permease PF07168.11 CDI74822.1 - 0.76 8.5 7.2 0.96 8.1 5.9 1.7 2 0 0 2 2 2 0 Ureide permease NPAT_C PF15712.5 CDI74822.1 - 4 6.0 11.7 5.6 5.5 11.7 1.2 1 0 0 1 1 1 0 NPAT C terminus TraT PF05818.12 CDI74822.1 - 4.6 6.9 9.3 12 5.5 6.0 2.3 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein O-antigen_lig PF13425.6 CDI74822.1 - 5.7 5.6 6.5 9.6 4.9 6.5 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Presenilin PF01080.17 CDI74822.1 - 7.6 5.2 24.0 0.31 9.8 10.0 2.1 2 0 0 2 2 2 0 Presenilin PA26 PF04636.13 CDI74822.1 - 8.9 5.1 9.5 12 4.7 9.5 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) RskA PF10099.9 CDI74823.1 - 0.00077 19.8 10.0 0.00077 19.8 10.0 4.6 2 1 1 3 3 3 1 Anti-sigma-K factor rskA Med3 PF11593.8 CDI74823.1 - 0.0022 17.3 12.7 0.0022 17.3 12.7 5.3 3 1 0 3 3 3 1 Mediator complex subunit 3 fungal TMEM247 PF15444.6 CDI74823.1 - 0.014 15.5 8.1 0.014 15.5 8.1 4.3 2 1 1 5 5 5 0 Transmembrane protein 247 Spt20 PF12090.8 CDI74823.1 - 0.016 14.8 28.3 0.016 14.8 28.3 4.8 2 1 2 4 4 4 0 Spt20 family AAA_23 PF13476.6 CDI74824.1 - 0.0018 18.8 5.3 0.0018 18.8 5.3 1.2 1 0 0 1 1 1 1 AAA domain eIF-3_zeta PF05091.12 CDI74824.1 - 0.086 11.8 11.1 0.091 11.7 11.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Auts2 PF15336.6 CDI74824.1 - 0.35 10.9 12.5 0.47 10.5 12.5 1.2 1 1 0 1 1 1 0 Autism susceptibility gene 2 protein TFIIA PF03153.13 CDI74824.1 - 0.74 9.7 50.2 0.94 9.4 50.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Connexin PF00029.19 CDI74824.1 - 1 9.1 5.7 1.3 8.7 5.7 1.4 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 CDI74824.1 - 5.9 4.7 11.1 6.9 4.4 11.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SpoIIP PF07454.11 CDI74824.1 - 6.7 6.1 14.9 0.87 9.0 11.3 1.5 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) RskA PF10099.9 CDI74825.1 - 3.6e-05 24.1 1.2 3.6e-05 24.1 1.2 5.5 1 1 3 4 4 3 1 Anti-sigma-K factor rskA Sporozoite_P67 PF05642.11 CDI74825.1 - 0.00057 18.1 1.0 0.00057 18.1 1.0 2.1 1 1 1 2 2 2 1 Sporozoite P67 surface antigen SID-1_RNA_chan PF13965.6 CDI74825.1 - 0.077 11.4 7.4 0.11 10.8 7.4 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CDC45 PF02724.14 CDI74825.1 - 0.56 8.4 23.6 0.071 11.4 6.5 2.4 3 0 0 3 3 3 0 CDC45-like protein BRF1 PF07741.13 CDI74825.1 - 0.97 9.8 24.4 0.63 10.4 9.4 3.5 3 0 0 3 3 3 0 Brf1-like TBP-binding domain Proton_antipo_C PF01010.19 CDI74825.1 - 2.3 7.8 6.9 4.4 6.8 6.9 1.5 1 0 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus DUF3807 PF12720.7 CDI74825.1 - 2.5 8.4 38.5 6.1 7.1 17.8 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) Spt5_N PF11942.8 CDI74825.1 - 4.8 8.2 27.4 1.6 9.8 8.9 3.2 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal DUF3371 PF11851.8 CDI74825.1 - 4.9 8.3 29.0 8.3 7.5 5.3 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3371) UPF0565 PF10561.9 CDI74825.1 - 6 6.0 11.9 1.3 8.2 4.6 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 Radial_spoke_3 PF06098.11 CDI74825.1 - 6.2 6.0 30.9 0.12 11.7 5.2 3.2 3 0 0 3 3 3 0 Radial spoke protein 3 PNISR PF15996.5 CDI74825.1 - 6.9 6.9 37.9 1.7 8.9 6.0 3.1 3 0 0 3 3 3 0 Arginine/serine-rich protein PNISR FAM60A PF15396.6 CDI74825.1 - 7.8 6.4 24.7 7.4 6.5 1.6 2.8 3 0 0 3 3 3 0 Protein Family FAM60A CPSF100_C PF13299.6 CDI74825.1 - 8 6.6 32.3 0.78 9.9 4.1 3.4 4 0 0 4 4 4 0 Cleavage and polyadenylation factor 2 C-terminal SR-25 PF10500.9 CDI74826.1 - 0.0046 16.6 20.1 0.0053 16.4 20.1 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein MPM1 PF17234.2 CDI74826.1 - 0.025 14.9 13.1 0.029 14.6 13.1 1.0 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 DUF4666 PF15697.5 CDI74826.1 - 0.16 12.7 7.3 0.2 12.4 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4666) eIF3_subunit PF08597.10 CDI74826.1 - 0.37 10.7 20.8 0.44 10.4 20.8 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit RNA_polI_A34 PF08208.11 CDI74826.1 - 0.52 10.4 22.4 0.6 10.2 22.4 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RcpC PF16976.5 CDI74826.1 - 0.56 10.3 6.7 0.79 9.8 6.7 1.3 1 0 0 1 1 1 0 Flp pilus assembly protein RcpC/CpaB GNT-I PF03071.15 CDI74826.1 - 0.61 8.8 7.4 0.69 8.6 7.4 1.0 1 0 0 1 1 1 0 GNT-I family TORC_M PF12885.7 CDI74826.1 - 1.1 9.1 6.2 1.3 9.0 6.2 1.1 1 0 0 1 1 1 0 Transducer of regulated CREB activity middle domain Rxt3 PF08642.10 CDI74826.1 - 1.6 9.5 6.5 1.9 9.3 6.5 1.3 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 YqfQ PF14181.6 CDI74826.1 - 2.9 8.1 14.5 3.2 7.9 14.5 1.1 1 0 0 1 1 1 0 YqfQ-like protein Protocadherin PF08374.11 CDI74826.1 - 3 7.8 12.3 3.4 7.6 12.3 1.1 1 0 0 1 1 1 0 Protocadherin IHABP4_N PF16174.5 CDI74826.1 - 3 8.4 21.1 3.2 8.3 20.5 1.3 1 1 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Rtf2 PF04641.12 CDI74826.1 - 3 7.1 17.9 3.4 6.9 17.9 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Sec62 PF03839.16 CDI74826.1 - 3.1 7.3 14.5 3.6 7.0 14.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 LYRIC PF15686.5 CDI74826.1 - 3.1 7.2 21.8 3.7 7.0 21.8 1.0 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Rrn6 PF10214.9 CDI74826.1 - 3.3 6.1 13.5 3.8 5.9 13.5 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor PcfK PF14058.6 CDI74826.1 - 4.7 7.5 20.0 6.4 7.1 20.0 1.3 1 0 0 1 1 1 0 PcfK-like protein GAGA_bind PF06217.12 CDI74826.1 - 5.5 7.2 17.0 6.2 7.0 17.0 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family Ferlin_C PF16165.5 CDI74826.1 - 5.8 6.9 12.2 6.9 6.6 12.2 1.4 1 0 0 1 1 1 0 Ferlin C-terminus DUF1764 PF08576.10 CDI74826.1 - 5.8 7.9 17.7 8.5 7.3 17.7 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF4887 PF16228.5 CDI74826.1 - 7.4 6.7 34.7 7 6.8 34.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4887) MAP17 PF15807.5 CDI74826.1 - 8.6 6.6 12.9 11 6.2 12.9 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF1168 PF06658.12 CDI74826.1 - 9.6 6.0 24.7 11 5.8 24.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Trp_oprn_chp PF09534.10 CDI74827.1 - 0.0046 16.8 11.5 0.0046 16.8 11.5 8.3 5 2 2 7 7 7 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) RskA PF10099.9 CDI74827.1 - 0.007 16.7 10.9 0.007 16.7 10.9 10.8 5 2 5 11 11 11 5 Anti-sigma-K factor rskA Trp_oprn_chp PF09534.10 CDI74828.1 - 0.0051 16.6 2.1 3.1 7.6 0.0 2.3 2 0 0 2 2 2 2 Tryptophan-associated transmembrane protein (Trp_oprn_chp) RskA PF10099.9 CDI74828.1 - 0.008 16.5 15.6 0.9 9.8 0.1 2.1 1 1 1 2 2 2 2 Anti-sigma-K factor rskA DUF3824 PF12868.7 CDI74828.1 - 0.0085 16.8 3.9 0.0085 16.8 3.9 1.8 1 1 0 1 1 1 1 Domain of unknwon function (DUF3824) Apt1 PF10351.9 CDI74828.1 - 0.018 13.9 14.6 0.02 13.7 14.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain TFIIA PF03153.13 CDI74828.1 - 0.018 15.0 14.9 0.027 14.5 14.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EssA PF10661.9 CDI74828.1 - 0.032 14.1 1.9 0.043 13.7 0.1 1.9 1 1 1 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA Cwf_Cwc_15 PF04889.12 CDI74828.1 - 0.048 13.4 9.4 0.069 12.9 9.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Macoilin PF09726.9 CDI74828.1 - 0.11 11.1 23.2 0.14 10.7 23.2 1.1 1 0 0 1 1 1 0 Macoilin family Utp14 PF04615.13 CDI74828.1 - 1.1 7.8 13.3 1.3 7.5 13.3 1.0 1 0 0 1 1 1 0 Utp14 protein CD20 PF04103.15 CDI74828.1 - 1.2 9.3 11.5 1.3 9.1 6.9 2.2 1 1 1 2 2 2 0 CD20-like family SPX PF03105.19 CDI74828.1 - 1.2 9.0 23.7 1.5 8.7 23.7 1.1 1 0 0 1 1 1 0 SPX domain SLC12 PF03522.15 CDI74828.1 - 2.7 6.9 10.8 3.3 6.6 10.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI74828.1 - 3 6.0 11.9 3.6 5.7 11.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Dynein_attach_N PF15867.5 CDI74828.1 - 4.9 7.2 6.8 61 3.7 4.5 2.6 3 0 0 3 3 3 0 Dynein attachment factor N-terminus RIFIN PF02009.16 CDI74828.1 - 5.4 6.8 7.3 7.2 6.4 7.3 1.1 1 0 0 1 1 1 0 Rifin TPPK_C PF12555.8 CDI74828.1 - 10 6.3 12.2 0.46 10.6 0.6 2.6 3 0 0 3 3 2 0 Thiamine pyrophosphokinase C terminal Dus PF01207.17 CDI74829.1 - 6.5e-12 45.2 18.2 4.3e-10 39.2 17.8 2.7 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Prim-Pol PF09250.11 CDI74829.1 - 0.21 11.9 0.8 0.44 10.9 0.3 1.8 2 0 0 2 2 2 0 Bifunctional DNA primase/polymerase, N-terminal DUF572 PF04502.13 CDI74829.1 - 5.5 6.5 13.3 4.5 6.8 0.5 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) DUF5588 PF17826.1 CDI74830.1 - 4.3e-05 22.6 10.2 5.2e-05 22.3 10.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5588) SseC PF04888.12 CDI74830.1 - 8.9e-05 22.2 7.4 8.9e-05 22.2 7.4 2.0 2 1 1 3 3 2 1 Secretion system effector C (SseC) like family CCSAP PF15748.5 CDI74830.1 - 0.0005 20.3 14.3 0.00077 19.7 14.3 1.3 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated DUF4207 PF13904.6 CDI74830.1 - 0.0011 18.7 15.9 0.0011 18.7 15.9 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4207) FAM199X PF15814.5 CDI74830.1 - 0.0012 18.0 15.4 0.0017 17.5 15.4 1.2 1 0 0 1 1 1 1 Protein family FAM199X APG9 PF04109.16 CDI74830.1 - 0.0045 16.1 0.3 0.0055 15.8 0.3 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 TCP PF03634.13 CDI74830.1 - 0.0048 17.5 10.0 0.0048 17.5 10.0 1.8 2 0 0 2 2 2 1 TCP family transcription factor ATP-synt_E PF05680.12 CDI74830.1 - 0.015 15.7 4.4 0.015 15.7 4.4 2.2 2 0 0 2 2 2 0 ATP synthase E chain Velvet PF11754.8 CDI74830.1 - 0.023 14.7 11.3 0.03 14.3 11.3 1.2 1 0 0 1 1 1 0 Velvet factor DUF2207 PF09972.9 CDI74830.1 - 0.034 12.9 0.0 0.04 12.7 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Nuc_sug_transp PF04142.15 CDI74830.1 - 0.058 12.6 0.7 0.083 12.0 0.7 1.3 1 0 0 1 1 1 0 Nucleotide-sugar transporter NapE PF06796.11 CDI74830.1 - 0.063 12.8 0.2 0.23 11.0 0.2 2.0 1 1 0 1 1 1 0 Periplasmic nitrate reductase protein NapE SOBP PF15279.6 CDI74830.1 - 0.091 13.4 16.7 0.11 13.1 16.7 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Neur_chan_memb PF02932.16 CDI74830.1 - 0.16 12.0 8.3 0.2 11.7 8.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Rgp1 PF08737.10 CDI74830.1 - 0.27 10.4 12.9 0.3 10.2 12.9 1.1 1 0 0 1 1 1 0 Rgp1 Neuraminidase PF18413.1 CDI74830.1 - 2 8.0 13.2 3 7.5 13.2 1.5 1 1 0 1 1 1 0 Neuraminidase-like domain Hid1 PF12722.7 CDI74830.1 - 2.8 6.0 13.2 3.3 5.7 13.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4407 PF14362.6 CDI74830.1 - 4.1 6.7 18.0 5.2 6.3 18.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4484 PF14831.6 CDI74830.1 - 4.7 7.2 16.3 8.3 6.4 16.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4484) O-antigen_lig PF13425.6 CDI74830.1 - 8.1 5.1 4.7 8.9 5.0 4.7 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Comm PF15957.5 CDI74830.1 - 9.8 6.6 7.6 15 5.9 7.6 1.5 1 1 0 1 1 1 0 Commissureless Sporozoite_P67 PF05642.11 CDI74831.1 - 0.068 11.2 13.5 0.12 10.5 13.5 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Presenilin PF01080.17 CDI74831.1 - 0.1 11.4 32.1 0.012 14.4 25.1 2.2 2 0 0 2 2 2 0 Presenilin SMYLE_N PF18615.1 CDI74831.1 - 9.8 5.6 29.1 2.5 7.6 1.4 2.3 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Golgin_A5 PF09787.9 CDI74832.1 - 0.036 13.5 19.6 0.035 13.6 19.6 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF4164 PF13747.6 CDI74832.1 - 0.051 13.8 10.0 0.063 13.6 9.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) HAUS6_N PF14661.6 CDI74832.1 - 0.067 12.8 18.3 0.084 12.4 18.3 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Allexi_40kDa PF05549.11 CDI74832.1 - 0.17 11.4 6.7 0.18 11.3 6.7 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein BioW PF03744.13 CDI74832.1 - 0.32 10.5 5.1 0.37 10.3 5.1 1.1 1 0 0 1 1 1 0 6-carboxyhexanoate--CoA ligase Jnk-SapK_ap_N PF09744.9 CDI74832.1 - 0.42 10.8 24.7 0.68 10.1 24.7 1.3 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 PRKCSH-like PF12999.7 CDI74832.1 - 0.5 10.1 7.6 0.59 9.9 7.6 1.1 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Atg14 PF10186.9 CDI74832.1 - 0.51 9.4 19.8 0.52 9.3 19.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FapA PF03961.13 CDI74832.1 - 0.6 8.7 9.9 0.61 8.6 9.9 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4446 PF14584.6 CDI74832.1 - 0.78 9.7 5.2 0.85 9.6 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Peptidase_S49_N PF08496.10 CDI74832.1 - 0.88 9.6 11.7 1 9.4 11.7 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal APG17 PF04108.12 CDI74832.1 - 0.89 8.6 21.9 1 8.4 21.9 1.0 1 0 0 1 1 1 0 Autophagy protein Apg17 AAA_lid_9 PF17871.1 CDI74832.1 - 1.1 9.2 16.1 0.087 12.8 4.6 2.1 1 1 1 2 2 2 0 AAA lid domain 5_nucleotid PF05761.14 CDI74832.1 - 1.3 7.9 12.0 1.5 7.7 12.0 1.1 1 0 0 1 1 1 0 5' nucleotidase family TMPIT PF07851.13 CDI74832.1 - 1.5 8.0 12.4 1.4 8.1 12.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein AAA_23 PF13476.6 CDI74832.1 - 1.5 9.3 20.4 1.5 9.2 20.4 1.1 1 0 0 1 1 1 0 AAA domain MCU PF04678.13 CDI74832.1 - 1.6 8.8 12.7 2.2 8.4 12.7 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter MAJIN PF15077.6 CDI74832.1 - 2 8.2 8.5 2.1 8.1 8.5 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF3810 PF12725.7 CDI74832.1 - 2.5 7.4 5.4 2.3 7.5 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) CemA PF03040.14 CDI74832.1 - 2.6 7.9 7.9 2.6 7.9 7.9 1.1 1 0 0 1 1 1 0 CemA family eIF-3_zeta PF05091.12 CDI74832.1 - 3.2 6.6 14.3 3.3 6.6 14.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NEMP PF10225.9 CDI74832.1 - 5.2 6.7 5.7 5.5 6.6 5.7 1.1 1 0 0 1 1 1 0 NEMP family Cob_adeno_trans PF01923.18 CDI74832.1 - 5.8 7.0 8.8 6.5 6.9 8.8 1.2 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Presenilin PF01080.17 CDI74832.1 - 6.7 5.4 11.7 6.1 5.5 11.7 1.0 1 0 0 1 1 1 0 Presenilin Serinc PF03348.15 CDI74832.1 - 7.6 5.3 5.7 7.9 5.3 5.7 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) IFT57 PF10498.9 CDI74832.1 - 8.1 5.3 22.4 11 4.9 22.4 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Nitroreductase PF00881.24 CDI74832.1 - 8.4 6.4 10.9 16 5.5 10.9 1.4 1 1 0 1 1 1 0 Nitroreductase family CLN3 PF02487.17 CDI74832.1 - 9.2 5.2 7.3 9.3 5.2 7.3 1.1 1 0 0 1 1 1 0 CLN3 protein Spt20 PF12090.8 CDI74833.1 - 0.00033 20.3 21.5 0.00033 20.3 21.5 11.1 5 3 5 10 10 10 2 Spt20 family RskA PF10099.9 CDI74833.1 - 0.0081 16.5 17.8 0.0081 16.5 17.8 15.8 2 2 9 11 11 11 2 Anti-sigma-K factor rskA Alpha-mann_mid PF09261.11 CDI74835.1 - 0.019 15.1 9.2 0.019 15.1 9.2 2.7 1 1 1 2 2 2 0 Alpha mannosidase middle domain Med15 PF09606.10 CDI74835.1 - 0.44 9.2 41.9 0.51 9.0 41.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Activator_LAG-3 PF11498.8 CDI74836.1 - 0.14 11.1 17.1 0.17 10.9 17.1 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 RRM_1 PF00076.22 CDI74837.1 - 2.2e-15 56.2 0.0 4.7e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) cwf21 PF08312.12 CDI74837.1 - 9.7e-13 48.0 5.0 9.7e-13 48.0 5.0 2.4 3 0 0 3 3 3 1 cwf21 domain Surp PF01805.20 CDI74837.1 - 3.1e-05 23.9 0.0 7.4e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Surp module CTK3 PF12243.8 CDI74837.1 - 0.00016 21.7 0.0 0.00031 20.7 0.0 1.4 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 Ku_C PF03730.14 CDI74837.1 - 1.2 9.9 9.1 0.092 13.5 2.8 2.6 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm Tubulin PF00091.25 CDI74838.1 - 6.4e-33 114.6 0.0 5.1e-25 88.8 0.0 2.4 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 CDI74838.1 - 0.0027 17.0 0.1 0.005 16.1 0.1 1.4 1 0 0 1 1 1 1 Tubulin like E1-E2_ATPase PF00122.20 CDI74839.1 - 9.6e-40 136.0 0.2 9.6e-40 136.0 0.2 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CDI74839.1 - 1.7e-18 67.7 0.1 3.4e-18 66.7 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CDI74839.1 - 4.7e-11 42.2 0.0 1.1e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CDI74839.1 - 0.00033 20.7 0.0 0.00069 19.7 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CDI74839.1 - 0.0027 17.5 0.1 0.0048 16.7 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4856 PF16148.5 CDI74840.1 - 0.016 14.3 0.4 0.42 9.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4856) UPF0139 PF03669.13 CDI74840.1 - 0.02 14.8 0.0 0.044 13.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) EF-hand_7 PF13499.6 CDI74841.1 - 4.4e-31 107.2 0.0 4.2e-10 39.9 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.32 CDI74841.1 - 2.8e-24 82.8 0.1 2.9e-05 23.3 0.0 6.1 6 0 0 6 6 6 4 EF hand EF-hand_6 PF13405.6 CDI74841.1 - 4.2e-23 79.2 0.3 0.00051 19.7 0.0 6.8 6 0 0 6 6 6 5 EF-hand domain EF-hand_8 PF13833.6 CDI74841.1 - 2.3e-22 78.6 0.0 1.3e-08 34.5 0.0 4.5 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 CDI74841.1 - 5.8e-17 60.3 1.8 5e-05 22.6 0.0 4.7 4 0 0 4 4 4 3 EF hand HAP2-GCS1 PF10699.9 CDI74841.1 - 3.4e-08 33.3 0.2 9.4e-08 31.9 0.2 1.9 1 0 0 1 1 1 1 Male gamete fusion factor SPARC_Ca_bdg PF10591.9 CDI74841.1 - 9.3e-05 22.7 0.5 0.0066 16.8 0.0 3.0 3 0 0 3 3 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 CDI74841.1 - 0.029 14.2 0.0 0.69 9.8 0.0 2.7 2 0 0 2 2 2 0 EF hand Dockerin_1 PF00404.18 CDI74841.1 - 0.077 13.2 0.8 12 6.2 0.0 3.5 2 1 1 3 3 3 0 Dockerin type I domain DUF1682 PF07946.14 CDI74841.1 - 0.17 11.1 3.3 0.28 10.4 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) MAS20 PF02064.15 CDI74841.1 - 3.2 7.9 8.2 6.6 6.8 8.2 1.4 1 0 0 1 1 1 0 MAS20 protein import receptor MSC PF09402.10 CDI74842.1 - 9.6e-15 54.9 0.8 1.2e-14 54.6 0.8 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain LRR_4 PF12799.7 CDI74843.1 - 1.2e-15 57.3 15.8 3.5e-06 27.3 0.5 5.3 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI74843.1 - 1.8e-14 53.2 12.8 2.6e-05 23.9 0.2 5.3 4 1 1 5 5 5 4 Leucine rich repeat LRR_9 PF14580.6 CDI74843.1 - 7e-07 28.9 1.5 0.00071 19.1 0.4 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 CDI74843.1 - 1.6e-05 24.6 6.2 0.87 9.8 0.0 6.6 8 0 0 8 8 8 2 Leucine Rich repeat LRR_1 PF00560.33 CDI74843.1 - 0.068 13.8 13.3 9.1 7.3 0.0 6.6 7 1 0 7 7 7 0 Leucine Rich Repeat zf-MYST PF17772.1 CDI74845.1 - 0.026 14.1 0.1 0.039 13.6 0.1 1.2 1 0 0 1 1 1 0 MYST family zinc finger domain HCBP_related PF06594.11 CDI74845.1 - 0.096 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Haemolysin-type calcium binding protein related domain RT_RNaseH_2 PF17919.1 CDI74846.1 - 1.4e-26 92.5 0.0 2.7e-26 91.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI74846.1 - 2.8e-16 59.7 0.0 6.8e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDI74846.1 - 7.4e-15 55.2 0.0 2.1e-14 53.7 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDI74846.1 - 1.3e-12 47.6 0.3 2.7e-12 46.6 0.3 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDI74846.1 - 5.3e-12 45.4 0.0 1e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RVT_1 PF00078.27 CDI74846.1 - 1.8e-09 37.4 0.0 3.4e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 CDI74846.1 - 0.03 14.5 0.3 0.15 12.3 0.2 2.1 2 0 0 2 2 2 0 H2C2 zinc finger rve_3 PF13683.6 CDI74846.1 - 0.1 12.4 0.2 0.29 10.9 0.2 1.7 1 0 0 1 1 1 0 Integrase core domain SecM PF06558.12 CDI74846.1 - 0.12 12.5 0.0 0.41 10.7 0.0 1.9 1 0 0 1 1 1 0 Secretion monitor precursor protein (SecM) PKS_DE PF18369.1 CDI74846.1 - 3.7 8.2 6.5 46 4.7 2.4 3.2 3 0 0 3 3 3 0 Polyketide synthase dimerisation element domain RVP_2 PF08284.11 CDI74847.1 - 1.5e-10 40.9 0.0 2.5e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CDI74847.1 - 5.5e-08 33.3 0.0 1.2e-07 32.3 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI74847.1 - 1.2e-07 32.2 0.0 3.4e-07 30.7 0.0 1.9 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 CDI74847.1 - 0.0013 18.5 0.0 0.0024 17.7 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 CDI74847.1 - 0.015 15.6 0.0 0.044 14.1 0.0 1.8 1 1 0 1 1 1 0 Retroviral aspartyl protease Surface_antigen PF11054.8 CDI74848.1 - 7.2e-38 130.6 0.5 1.9e-37 129.2 0.5 1.6 1 1 0 1 1 1 1 Sporozoite TA4 surface antigen BSP_II PF05432.11 CDI74848.1 - 0.051 13.3 1.8 0.095 12.4 1.8 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Roughex PF06020.11 CDI74848.1 - 2.4 7.2 4.4 4.1 6.4 4.4 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Surface_antigen PF11054.8 CDI74849.1 - 9.7e-35 120.4 3.0 1.2e-34 120.1 3.0 1.1 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen Surface_antigen PF11054.8 CDI74850.1 - 6.2e-34 117.8 3.7 8e-34 117.4 3.7 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen Surface_antigen PF11054.8 CDI74851.1 - 1.9e-34 119.5 9.1 2.3e-34 119.2 9.1 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen Surface_antigen PF11054.8 CDI74852.1 - 4.3e-33 115.0 8.0 5.3e-33 114.7 8.0 1.1 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen Asp_protease PF09668.10 CDI74853.1 - 8.7e-50 167.7 0.0 1.7e-49 166.7 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI74853.1 - 5.5e-19 68.5 0.0 1.1e-18 67.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease ubiquitin PF00240.23 CDI74853.1 - 3.1e-09 36.5 0.0 6.5e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Asp_protease_2 PF13650.6 CDI74853.1 - 1.9e-08 34.9 0.0 3.8e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 CDI74853.1 - 1.2e-05 25.0 0.0 5.9e-05 22.9 0.0 2.0 2 1 0 2 2 2 1 Retroviral aspartyl protease VirionAssem_T7 PF11653.8 CDI74853.1 - 0.017 15.7 0.7 0.017 15.7 0.7 2.6 3 0 0 3 3 3 0 Bacteriophage T7 virion assembly protein RVP PF00077.20 CDI74853.1 - 0.023 15.0 0.0 0.087 13.1 0.0 2.0 1 1 0 1 1 1 0 Retroviral aspartyl protease DUF2052 PF09747.9 CDI74856.1 - 0.00078 19.6 7.4 0.00078 19.6 7.4 1.0 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) SpoIIP PF07454.11 CDI74856.1 - 0.0057 16.2 8.4 0.0057 16.2 8.4 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) RPN2_C PF18004.1 CDI74856.1 - 0.0069 16.3 7.2 0.0078 16.1 7.2 1.1 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain FAM176 PF14851.6 CDI74856.1 - 0.0085 15.8 2.0 0.01 15.5 2.0 1.2 1 0 0 1 1 1 1 FAM176 family Pex14_N PF04695.13 CDI74856.1 - 0.0098 16.6 21.5 0.013 16.1 21.5 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DDHD PF02862.17 CDI74856.1 - 0.012 15.7 7.9 0.011 15.9 7.9 1.1 1 0 0 1 1 1 0 DDHD domain TFIIA PF03153.13 CDI74856.1 - 0.013 15.5 37.8 0.014 15.4 37.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Folate_carrier PF01770.18 CDI74856.1 - 0.015 14.0 4.7 0.019 13.7 4.7 1.0 1 0 0 1 1 1 0 Reduced folate carrier CCSAP PF15748.5 CDI74856.1 - 0.018 15.2 11.6 0.019 15.1 11.6 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated MecA PF05389.12 CDI74856.1 - 0.019 14.6 5.2 0.019 14.6 5.2 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Presenilin PF01080.17 CDI74856.1 - 0.021 13.6 13.6 0.022 13.6 13.6 1.0 1 0 0 1 1 1 0 Presenilin DUF4471 PF14740.6 CDI74856.1 - 0.027 13.7 6.5 0.025 13.8 6.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) CPSF100_C PF13299.6 CDI74856.1 - 0.049 13.8 8.2 0.056 13.6 8.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal MDM10 PF12519.8 CDI74856.1 - 0.05 12.5 5.3 0.046 12.6 5.3 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 OATP PF03137.20 CDI74856.1 - 0.053 11.8 3.9 0.056 11.7 3.9 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3306 PF11748.8 CDI74856.1 - 0.054 14.4 9.0 0.067 14.1 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Senescence_reg PF04520.13 CDI74856.1 - 0.07 14.0 7.1 0.069 14.0 7.1 1.1 1 0 0 1 1 1 0 Senescence regulator EIF4E-T PF10477.9 CDI74856.1 - 0.074 11.9 25.4 0.092 11.6 25.4 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Velvet PF11754.8 CDI74856.1 - 0.086 12.8 11.5 0.084 12.8 11.5 1.1 1 0 0 1 1 1 0 Velvet factor Tim54 PF11711.8 CDI74856.1 - 0.11 11.3 8.1 0.11 11.2 8.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SLC12 PF03522.15 CDI74856.1 - 0.11 11.5 11.3 0.12 11.4 11.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Lin-8 PF03353.15 CDI74856.1 - 0.11 12.0 15.2 0.11 12.0 15.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF3402 PF11882.8 CDI74856.1 - 0.11 11.6 13.5 0.12 11.4 13.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) PIG-S PF10510.9 CDI74856.1 - 0.11 11.3 12.2 0.11 11.3 12.2 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein ABC2_membrane_2 PF12679.7 CDI74856.1 - 0.12 11.7 3.2 0.12 11.6 3.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Connexin PF00029.19 CDI74856.1 - 0.12 12.1 9.2 0.13 12.0 9.2 1.1 1 0 0 1 1 1 0 Connexin Dpy19 PF10034.9 CDI74856.1 - 0.12 10.6 1.8 0.11 10.6 1.8 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation DUF572 PF04502.13 CDI74856.1 - 0.17 11.5 10.3 0.2 11.3 10.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Band_3_cyto PF07565.13 CDI74856.1 - 0.22 11.3 13.0 0.24 11.1 13.0 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CCDC53 PF10152.9 CDI74856.1 - 0.23 11.9 13.7 0.28 11.6 13.7 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Hydin_ADK PF17213.3 CDI74856.1 - 0.26 11.5 8.9 0.36 11.1 8.9 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain PIP5K PF01504.18 CDI74856.1 - 0.27 10.4 10.2 0.32 10.2 10.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase PAT1 PF09770.9 CDI74856.1 - 0.3 9.3 26.9 0.29 9.4 26.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ctr PF04145.15 CDI74856.1 - 0.34 11.5 5.8 0.38 11.4 5.8 1.2 1 0 0 1 1 1 0 Ctr copper transporter family O-antigen_lig PF13425.6 CDI74856.1 - 0.35 9.6 3.2 0.37 9.5 3.2 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CNDH2_M PF16869.5 CDI74856.1 - 0.47 11.1 7.8 0.61 10.8 7.8 1.3 1 0 0 1 1 1 0 PF16858 Pal1 PF08316.11 CDI74856.1 - 0.48 11.2 4.3 0.59 10.9 4.3 1.2 1 0 0 1 1 1 0 Pal1 cell morphology protein CLN3 PF02487.17 CDI74856.1 - 0.49 9.4 9.8 0.59 9.1 9.8 1.1 1 0 0 1 1 1 0 CLN3 protein Scs3p PF10261.9 CDI74856.1 - 0.54 9.7 3.0 0.65 9.5 3.0 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Gti1_Pac2 PF09729.9 CDI74856.1 - 0.58 10.2 8.7 0.74 9.9 8.7 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family DUF1180 PF06679.12 CDI74856.1 - 0.58 10.6 4.9 0.7 10.3 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) SLD3 PF08639.10 CDI74856.1 - 0.62 8.7 15.8 0.65 8.7 15.8 1.0 1 0 0 1 1 1 0 DNA replication regulator SLD3 Peptidase_S49_N PF08496.10 CDI74856.1 - 0.76 9.8 15.7 0.93 9.5 15.7 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal R_equi_Vir PF05526.11 CDI74856.1 - 0.8 9.5 5.1 0.96 9.3 5.1 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF2149 PF09919.9 CDI74856.1 - 0.87 9.9 7.3 1.2 9.4 7.3 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) GREB1 PF15782.5 CDI74856.1 - 1.1 6.3 13.4 0.98 6.5 13.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 CDI74856.1 - 1.1 9.3 11.6 1.1 9.2 11.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PepSY_TM PF03929.16 CDI74856.1 - 1.1 8.8 7.3 1.2 8.8 7.3 1.2 1 0 0 1 1 1 0 PepSY-associated TM region Mcm10 PF09332.11 CDI74856.1 - 1.2 8.5 16.7 1.4 8.3 16.7 1.1 1 0 0 1 1 1 0 Mcm10 replication factor MscS_TM PF12794.7 CDI74856.1 - 1.2 7.9 9.6 1.4 7.7 9.6 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 YABBY PF04690.13 CDI74856.1 - 1.2 9.7 10.6 1.5 9.4 10.6 1.2 1 0 0 1 1 1 0 YABBY protein Ureide_permease PF07168.11 CDI74856.1 - 1.2 7.8 4.7 1.5 7.5 4.7 1.1 1 0 0 1 1 1 0 Ureide permease RR_TM4-6 PF06459.12 CDI74856.1 - 1.5 8.6 14.1 1.9 8.2 14.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PTPRCAP PF15713.5 CDI74856.1 - 1.6 9.0 16.7 2.1 8.7 16.7 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated MMR1 PF08505.10 CDI74856.1 - 1.7 8.9 18.4 1.9 8.7 18.4 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Nucleoside_tran PF01733.18 CDI74856.1 - 1.8 7.9 4.6 2.2 7.6 4.6 1.1 1 0 0 1 1 1 0 Nucleoside transporter ATAD4 PF15321.6 CDI74856.1 - 1.8 10.0 11.1 2.6 9.5 11.1 1.2 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 PIEZO PF15917.5 CDI74856.1 - 1.9 7.9 20.3 2.3 7.6 20.3 1.1 1 0 0 1 1 1 0 Piezo Peroxin-13_N PF04088.13 CDI74856.1 - 2.1 8.6 9.7 2.9 8.2 9.7 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Ndc1_Nup PF09531.10 CDI74856.1 - 2.3 6.8 10.8 2 7.0 10.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Glyco_transf_41 PF13844.6 CDI74856.1 - 2.5 6.5 7.6 2.6 6.4 7.6 1.0 1 0 0 1 1 1 0 Glycosyl transferase family 41 F-protein PF00469.20 CDI74856.1 - 2.5 7.6 12.7 2.8 7.5 12.7 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef DUF4638 PF15472.6 CDI74856.1 - 2.6 7.7 12.5 3 7.5 12.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Plasmodium_Vir PF05795.11 CDI74856.1 - 3 7.2 5.3 2.7 7.3 5.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein MAJIN PF15077.6 CDI74856.1 - 3.6 7.3 8.7 4.2 7.1 8.7 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Med15 PF09606.10 CDI74856.1 - 3.7 6.1 39.3 4.7 5.8 39.3 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal V_ATPase_I PF01496.19 CDI74856.1 - 3.9 5.3 17.9 4.3 5.1 17.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Het-C PF07217.11 CDI74856.1 - 3.9 5.9 12.7 4.3 5.8 12.7 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Asparaginase_2 PF01112.18 CDI74856.1 - 4 6.4 6.4 4.3 6.3 6.4 1.1 1 0 0 1 1 1 0 Asparaginase CobT PF06213.12 CDI74856.1 - 4.2 6.7 23.7 5.6 6.3 23.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Ketoacyl-synt_2 PF13723.6 CDI74856.1 - 4.7 6.8 18.0 6.2 6.4 18.0 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain SID-1_RNA_chan PF13965.6 CDI74856.1 - 5.5 5.3 7.8 6.7 5.0 7.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 eIF-3_zeta PF05091.12 CDI74856.1 - 5.8 5.8 24.9 7.2 5.5 24.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4199 PF13858.6 CDI74856.1 - 5.8 7.3 6.3 7.5 6.9 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) CBP_BcsG PF11658.8 CDI74856.1 - 5.9 5.2 15.5 7.7 4.8 15.5 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Zip PF02535.22 CDI74856.1 - 6.3 5.9 7.3 7.7 5.6 7.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Herpes_DNAp_acc PF04929.12 CDI74856.1 - 6.5 5.6 10.5 6.9 5.5 10.5 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Serinc PF03348.15 CDI74856.1 - 6.7 5.5 11.5 7.5 5.4 11.5 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) ALMT PF11744.8 CDI74856.1 - 6.7 5.4 11.8 7.7 5.2 11.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter FHIPEP PF00771.20 CDI74856.1 - 6.9 5.0 10.8 8.4 4.7 10.8 1.1 1 0 0 1 1 1 0 FHIPEP family Kei1 PF08552.11 CDI74856.1 - 7 6.5 10.4 10 6.0 10.4 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Rrn6 PF10214.9 CDI74856.1 - 7.6 4.9 21.5 7.6 4.9 21.5 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DcuA_DcuB PF03605.14 CDI74856.1 - 7.6 5.3 6.2 9.4 5.0 6.2 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter AUX_IAA PF02309.16 CDI74856.1 - 8.5 6.2 12.6 10 5.9 12.6 1.1 1 0 0 1 1 1 0 AUX/IAA family Membralin PF09746.9 CDI74856.1 - 8.6 5.3 10.6 10 5.1 10.6 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF4746 PF15928.5 CDI74856.1 - 9 5.6 11.6 11 5.3 11.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF1980 PF09323.10 CDI74857.1 - 1.4 8.8 7.3 2 8.3 7.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) TFIIA PF03153.13 CDI74857.1 - 2.1 8.3 48.1 2.9 7.8 48.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI74857.1 - 4.8 5.3 28.7 5.4 5.2 28.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SR-25 PF10500.9 CDI74858.1 - 0.00042 20.0 27.4 0.00042 20.0 27.4 10.7 6 4 4 10 10 10 1 Nuclear RNA-splicing-associated protein PAP1 PF08601.10 CDI74858.1 - 0.00097 19.0 6.1 0.00097 19.0 6.1 8.0 3 3 3 6 6 6 1 Transcription factor PAP1 DUF2722 PF10846.8 CDI74859.1 - 0.0024 16.9 5.0 0.0024 16.9 5.0 1.9 3 0 0 3 3 3 1 Protein of unknown function (DUF2722) Pep3_Vps18 PF05131.14 CDI74859.1 - 0.02 14.7 1.0 0.45 10.3 0.0 2.5 2 0 0 2 2 2 0 Pep3/Vps18/deep orange family LCD1 PF09798.9 CDI74859.1 - 0.033 12.7 1.3 0.12 10.9 1.1 1.9 2 0 0 2 2 2 0 DNA damage checkpoint protein DUF3523 PF12037.8 CDI74859.1 - 0.077 12.4 20.1 0.21 11.0 20.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3523) Spt20 PF12090.8 CDI74859.1 - 0.99 9.0 18.8 0.029 14.0 12.4 1.7 2 0 0 2 2 2 0 Spt20 family Presenilin PF01080.17 CDI74859.1 - 1.4 7.6 4.9 2.1 7.0 4.9 1.2 1 0 0 1 1 1 0 Presenilin AAA_23 PF13476.6 CDI74859.1 - 10 6.6 12.3 14 6.1 8.8 2.3 2 0 0 2 2 2 0 AAA domain BAF1_ABF1 PF04684.13 CDI74860.1 - 0.033 13.3 0.3 0.045 12.8 0.3 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor PHM7_cyt PF14703.6 CDI74860.1 - 0.2 11.9 2.9 12 6.1 0.0 2.9 2 1 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Glyco_hydro_9 PF00759.19 CDI74860.1 - 0.37 10.2 8.6 1.4 8.3 3.8 2.2 2 0 0 2 2 2 0 Glycosyl hydrolase family 9 DUF4179 PF13786.6 CDI74860.1 - 1.6 9.2 0.0 1.6 9.2 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) DUF3123 PF11321.8 CDI74860.1 - 1.9 9.2 6.8 1.6 9.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) Spt20 PF12090.8 CDI74861.1 - 0.0021 17.7 32.7 0.003 17.2 32.7 1.3 1 0 0 1 1 1 1 Spt20 family SpoIIP PF07454.11 CDI74861.1 - 0.0064 16.0 11.5 0.0065 16.0 11.5 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Pal1 PF08316.11 CDI74861.1 - 0.0082 16.9 3.7 0.013 16.3 3.7 1.3 1 0 0 1 1 1 1 Pal1 cell morphology protein PI3K_1B_p101 PF10486.9 CDI74861.1 - 0.0087 13.9 9.7 0.01 13.6 9.7 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF4770 PF15994.5 CDI74861.1 - 0.0088 16.3 6.7 0.01 16.1 6.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4770) T4SS-DNA_transf PF02534.14 CDI74861.1 - 0.011 14.6 4.0 0.013 14.4 4.0 1.0 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer TERB2 PF15101.6 CDI74861.1 - 0.012 15.7 15.4 0.014 15.4 15.4 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 MPM1 PF17234.2 CDI74861.1 - 0.013 15.8 14.5 0.017 15.4 14.5 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 MMR1 PF08505.10 CDI74861.1 - 0.013 15.8 14.8 0.014 15.7 14.8 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein UPF0524 PF15823.5 CDI74861.1 - 0.014 14.8 2.3 0.015 14.7 2.3 1.3 1 0 0 1 1 1 0 UPF0524 of C3orf70 DDRGK PF09756.9 CDI74861.1 - 0.014 15.0 21.0 0.022 14.3 21.0 1.2 1 0 0 1 1 1 0 DDRGK domain Mitofilin PF09731.9 CDI74861.1 - 0.018 13.9 25.7 0.02 13.8 25.7 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein CLN3 PF02487.17 CDI74861.1 - 0.018 14.1 7.4 0.021 13.9 7.4 1.2 1 0 0 1 1 1 0 CLN3 protein CNDH2_C PF16858.5 CDI74861.1 - 0.019 14.8 14.0 0.02 14.8 14.0 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF913 PF06025.12 CDI74861.1 - 0.02 13.9 6.8 0.021 13.8 6.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3506 PF12014.8 CDI74861.1 - 0.02 14.9 2.1 0.026 14.5 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3506) Presenilin PF01080.17 CDI74861.1 - 0.02 13.7 15.4 0.02 13.7 15.4 1.1 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 CDI74861.1 - 0.02 13.7 11.1 0.024 13.5 11.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Band_3_cyto PF07565.13 CDI74861.1 - 0.021 14.7 11.9 0.024 14.4 11.9 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Membralin PF09746.9 CDI74861.1 - 0.022 13.8 4.8 0.022 13.8 4.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein CSG2 PF16965.5 CDI74861.1 - 0.03 13.3 4.3 0.034 13.1 4.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Hid1 PF12722.7 CDI74861.1 - 0.031 12.4 13.1 0.034 12.3 13.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4638 PF15472.6 CDI74861.1 - 0.037 13.7 6.5 0.038 13.7 6.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF2052 PF09747.9 CDI74861.1 - 0.038 14.1 18.2 0.05 13.7 18.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Velvet PF11754.8 CDI74861.1 - 0.041 13.8 9.1 0.046 13.7 9.1 1.2 1 0 0 1 1 1 0 Velvet factor TFIIA PF03153.13 CDI74861.1 - 0.042 13.9 37.1 0.052 13.5 37.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ALMT PF11744.8 CDI74861.1 - 0.046 12.6 12.5 0.05 12.4 12.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 CDI74861.1 - 0.046 13.8 9.0 0.053 13.6 9.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PIP5K PF01504.18 CDI74861.1 - 0.051 12.8 8.5 0.064 12.5 8.5 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase SID-1_RNA_chan PF13965.6 CDI74861.1 - 0.061 11.7 3.8 0.067 11.6 3.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Connexin PF00029.19 CDI74861.1 - 0.064 13.0 8.2 0.075 12.8 8.2 1.2 1 0 0 1 1 1 0 Connexin Draxin PF15550.6 CDI74861.1 - 0.071 13.0 9.3 0.084 12.7 9.3 1.0 1 0 0 1 1 1 0 Draxin CSRNP_N PF16019.5 CDI74861.1 - 0.074 13.0 10.5 0.086 12.7 10.5 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus EOS1 PF12326.8 CDI74861.1 - 0.078 12.9 3.2 0.095 12.6 3.2 1.2 1 0 0 1 1 1 0 N-glycosylation protein NPR3 PF03666.13 CDI74861.1 - 0.087 11.6 10.3 0.088 11.6 10.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF5523 PF17661.1 CDI74861.1 - 0.13 11.9 16.3 0.19 11.4 16.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) RLL PF10036.9 CDI74861.1 - 0.15 11.9 17.6 0.2 11.5 17.6 1.3 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein Gti1_Pac2 PF09729.9 CDI74861.1 - 0.15 12.1 10.2 0.18 11.9 10.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Med15 PF09606.10 CDI74861.1 - 0.17 10.5 31.9 0.2 10.3 31.9 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Lin-8 PF03353.15 CDI74861.1 - 0.22 11.0 18.6 0.24 10.9 18.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist FAM60A PF15396.6 CDI74861.1 - 0.22 11.5 7.1 0.22 11.5 7.1 1.3 1 0 0 1 1 1 0 Protein Family FAM60A UPF0560 PF10577.9 CDI74861.1 - 0.23 9.9 21.5 0.27 9.7 21.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 SLC12 PF03522.15 CDI74861.1 - 0.24 10.4 15.2 0.26 10.3 15.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Otopetrin PF03189.13 CDI74861.1 - 0.26 10.1 5.1 0.26 10.1 5.1 1.1 1 0 0 1 1 1 0 Otopetrin DUF3292 PF11696.8 CDI74861.1 - 0.29 9.4 14.4 0.36 9.2 14.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) XRN_M PF17846.1 CDI74861.1 - 0.32 9.9 10.5 0.38 9.7 10.5 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Miga PF10265.9 CDI74861.1 - 0.33 9.9 11.3 0.37 9.7 11.3 1.0 1 0 0 1 1 1 0 Mitoguardin LRRC37AB_C PF14914.6 CDI74861.1 - 0.4 10.6 15.1 0.51 10.3 15.1 1.2 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain O-antigen_lig PF13425.6 CDI74861.1 - 0.44 9.3 3.3 0.48 9.1 3.3 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein V_ATPase_I PF01496.19 CDI74861.1 - 0.47 8.3 15.9 0.55 8.1 15.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Glt_symporter PF03616.14 CDI74861.1 - 0.47 9.1 2.1 0.68 8.6 2.1 1.3 1 0 0 1 1 1 0 Sodium/glutamate symporter eIF-3_zeta PF05091.12 CDI74861.1 - 0.51 9.2 18.0 0.59 9.0 18.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MAT1 PF06391.13 CDI74861.1 - 0.55 10.0 21.6 0.74 9.6 21.6 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF1980 PF09323.10 CDI74861.1 - 0.55 10.1 9.0 0.74 9.7 9.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) EMC3_TMCO1 PF01956.16 CDI74861.1 - 0.6 9.8 10.8 0.71 9.6 10.8 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Mem_trans PF03547.18 CDI74861.1 - 0.61 8.4 2.8 0.7 8.2 2.8 1.2 1 0 0 1 1 1 0 Membrane transport protein Plasmodium_Vir PF05795.11 CDI74861.1 - 0.69 9.3 10.2 0.81 9.0 10.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Coilin_N PF15862.5 CDI74861.1 - 0.7 9.7 14.3 1.2 8.9 14.3 1.5 1 0 0 1 1 1 0 Coilin N-terminus OATP PF03137.20 CDI74861.1 - 0.83 7.9 6.4 0.95 7.7 6.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family PPL5 PF18168.1 CDI74861.1 - 0.86 8.8 12.0 1 8.6 12.0 1.1 1 0 0 1 1 1 0 Prim-pol family 5 GREB1 PF15782.5 CDI74861.1 - 0.88 6.6 15.6 0.9 6.6 15.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Dynactin_p62 PF05502.13 CDI74861.1 - 0.95 8.2 11.8 1.1 7.9 11.8 1.1 1 0 0 1 1 1 0 Dynactin p62 family PAT1 PF09770.9 CDI74861.1 - 1 7.6 25.6 1.1 7.4 25.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S64 PF08192.11 CDI74861.1 - 1.1 7.7 12.0 1.2 7.6 12.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF3381 PF11861.8 CDI74861.1 - 1.1 9.0 19.2 1.9 8.3 19.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF2126 PF09899.9 CDI74861.1 - 1.2 7.2 9.2 1.2 7.1 9.2 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Cellulose_synt PF03552.14 CDI74861.1 - 1.4 7.3 4.7 1.5 7.2 4.7 1.0 1 0 0 1 1 1 0 Cellulose synthase BAF1_ABF1 PF04684.13 CDI74861.1 - 1.4 7.9 24.4 1.8 7.5 24.4 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor MDM31_MDM32 PF08118.11 CDI74861.1 - 1.4 7.5 8.1 1.8 7.2 8.1 1.3 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins MAJIN PF15077.6 CDI74861.1 - 1.5 8.6 7.5 1.7 8.4 7.5 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Mcm10 PF09332.11 CDI74861.1 - 1.7 8.0 21.2 2.1 7.7 21.2 1.1 1 0 0 1 1 1 0 Mcm10 replication factor NEMP PF10225.9 CDI74861.1 - 1.7 8.3 5.0 2.4 7.8 5.0 1.3 1 0 0 1 1 1 0 NEMP family Sec62 PF03839.16 CDI74861.1 - 2 7.9 10.6 2.7 7.5 10.6 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Saw1 PF11561.8 CDI74861.1 - 2 7.9 11.6 2.5 7.6 11.6 1.2 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Sporozoite_P67 PF05642.11 CDI74861.1 - 2 6.4 10.0 2.1 6.3 10.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen XAP5 PF04921.14 CDI74861.1 - 2.1 8.1 12.5 3.1 7.6 12.5 1.4 1 0 0 1 1 1 0 XAP5, circadian clock regulator ABC2_membrane_2 PF12679.7 CDI74861.1 - 2.2 7.5 8.8 2.8 7.1 8.4 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein Baculo_PP31 PF05311.11 CDI74861.1 - 2.4 7.6 12.5 3.2 7.2 12.5 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF966 PF06136.13 CDI74861.1 - 2.4 7.8 15.1 2.9 7.5 15.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) HCO3_cotransp PF00955.21 CDI74861.1 - 2.5 6.8 4.4 2.7 6.7 4.4 1.2 1 0 0 1 1 1 0 HCO3- transporter family FliP PF00813.20 CDI74861.1 - 4.4 7.1 5.9 5 7.0 5.9 1.3 1 0 0 1 1 1 0 FliP family Paf1 PF03985.13 CDI74861.1 - 5.2 6.0 23.5 7.4 5.5 23.5 1.2 1 0 0 1 1 1 0 Paf1 Rrn6 PF10214.9 CDI74861.1 - 5.6 5.3 18.4 6 5.2 18.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor AUX_IAA PF02309.16 CDI74861.1 - 6.9 6.5 11.9 9 6.1 11.9 1.3 1 0 0 1 1 1 0 AUX/IAA family PigN PF04987.14 CDI74861.1 - 8.9 5.1 6.3 11 4.8 6.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Bac_DnaA PF00308.18 CDI74862.1 - 0.0049 16.7 0.2 0.018 14.9 0.2 2.0 1 0 0 1 1 1 1 Bacterial dnaA protein Chromo PF00385.24 CDI74862.1 - 0.0072 16.2 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Wzy_C PF04932.15 CDI74862.1 - 0.013 15.1 0.2 0.19 11.3 0.0 2.7 2 0 0 2 2 2 0 O-Antigen ligase SR-25 PF10500.9 CDI74863.1 - 0.0034 17.0 2.6 0.0034 17.0 2.6 5.6 5 1 1 6 6 6 1 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI74863.1 - 0.0047 17.2 10.3 0.0047 17.2 10.3 8.4 2 2 4 6 6 6 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI74863.1 - 0.0085 15.7 2.5 0.0085 15.7 2.5 7.2 4 2 1 6 6 6 2 Spt20 family PAP1 PF08601.10 CDI74863.1 - 3.8 7.1 0.0 1.5 8.4 0.0 5.0 3 2 2 5 5 5 0 Transcription factor PAP1 SR-25 PF10500.9 CDI74865.1 - 1.1 8.8 36.1 0.55 9.8 2.2 4.6 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein Ribosomal_L12 PF00542.19 CDI74866.1 - 0.29 11.5 9.9 25 5.3 0.1 5.1 5 0 0 5 5 5 0 Ribosomal protein L7/L12 C-terminal domain BCA_ABC_TP_C PF12399.8 CDI74866.1 - 1 9.3 7.4 25 4.9 0.2 6.2 6 0 0 6 6 6 0 Branched-chain amino acid ATP-binding cassette transporter DUF2126 PF09899.9 CDI74867.1 - 0.0013 16.9 8.0 0.002 16.3 8.0 1.2 1 0 0 1 1 1 1 Putative amidoligase enzyme (DUF2126) PIP5K PF01504.18 CDI74867.1 - 0.038 13.2 7.2 0.055 12.7 7.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase EOS1 PF12326.8 CDI74867.1 - 0.058 13.3 0.4 0.099 12.6 0.4 1.5 1 0 0 1 1 1 0 N-glycosylation protein DDHD PF02862.17 CDI74867.1 - 0.061 13.5 7.8 0.17 12.0 6.7 2.1 2 0 0 2 2 2 0 DDHD domain Suf PF05843.14 CDI74867.1 - 0.065 13.2 16.6 0.14 12.1 16.6 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) V_ATPase_I PF01496.19 CDI74867.1 - 0.18 9.7 9.2 0.24 9.2 9.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SpoIIP PF07454.11 CDI74867.1 - 0.22 11.0 11.4 0.36 10.2 11.4 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FAM60A PF15396.6 CDI74867.1 - 0.57 10.2 6.0 1 9.3 6.0 1.5 1 0 0 1 1 1 0 Protein Family FAM60A CSG2 PF16965.5 CDI74867.1 - 0.62 8.9 4.7 1 8.2 4.7 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator Connexin PF00029.19 CDI74867.1 - 0.73 9.6 8.3 1.3 8.7 8.3 1.3 1 0 0 1 1 1 0 Connexin Neur_chan_memb PF02932.16 CDI74867.1 - 1 9.3 9.1 2 8.4 9.1 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4228 PF14009.6 CDI74867.1 - 1.3 9.4 9.2 8.4 6.7 4.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) DUF4770 PF15994.5 CDI74867.1 - 2.4 8.4 26.9 2.2 8.5 19.2 2.7 3 1 1 4 4 2 0 Domain of unknown function (DUF4770) DUF2722 PF10846.8 CDI74867.1 - 3.4 6.5 32.0 7.2 5.4 32.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Presenilin PF01080.17 CDI74867.1 - 3.4 6.3 16.4 0.31 9.7 11.9 1.6 2 0 0 2 2 2 0 Presenilin Serinc PF03348.15 CDI74867.1 - 4.6 6.1 4.9 7.7 5.3 4.9 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Band_3_cyto PF07565.13 CDI74867.1 - 5.6 6.7 12.6 9.1 6.0 12.6 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain AIF_C PF14721.6 CDI74867.1 - 6.9 7.0 16.6 0.24 11.7 9.0 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Spt20 PF12090.8 CDI74867.1 - 8 6.0 43.6 1.8 8.1 39.4 2.0 2 0 0 2 2 2 0 Spt20 family Coilin_N PF15862.5 CDI74867.1 - 9.5 6.0 17.0 0.23 11.2 10.5 1.6 2 0 0 2 2 1 0 Coilin N-terminus Baculo_PP31 PF05311.11 CDI74867.1 - 10 5.5 13.1 8 5.9 11.7 1.5 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Raftlin PF15250.6 CDI74868.1 - 0.062 12.0 0.1 0.11 11.2 0.1 1.3 1 0 0 1 1 1 0 Raftlin RR_TM4-6 PF06459.12 CDI74869.1 - 0.038 13.8 30.9 0.04 13.7 30.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2052 PF09747.9 CDI74869.1 - 0.13 12.4 31.6 0.14 12.3 31.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) eIF3_subunit PF08597.10 CDI74869.1 - 0.34 10.8 24.7 0.39 10.6 24.7 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Rtf2 PF04641.12 CDI74869.1 - 0.37 10.1 23.7 0.41 10.0 23.7 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger CCSAP PF15748.5 CDI74869.1 - 1.2 9.3 36.8 1.3 9.1 36.8 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Lin-8 PF03353.15 CDI74869.1 - 1.8 8.0 40.0 2.2 7.8 40.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 CDI74869.1 - 1.9 6.7 31.2 2.1 6.6 31.2 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.6 CDI74869.1 - 2.5 7.7 29.1 2.7 7.5 29.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) AAA_11 PF13086.6 CDI74869.1 - 3.4 7.4 29.5 3.8 7.2 29.5 1.1 1 0 0 1 1 1 0 AAA domain TFIIA PF03153.13 CDI74869.1 - 3.6 7.5 66.4 5.4 6.9 66.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GAGA_bind PF06217.12 CDI74869.1 - 4 7.6 27.5 4.4 7.5 27.5 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family DUF1387 PF07139.11 CDI74869.1 - 4.4 7.0 31.4 5.1 6.7 31.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) SLC12 PF03522.15 CDI74869.1 - 4.5 6.2 34.8 5.2 6.0 34.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 GREB1 PF15782.5 CDI74869.1 - 5.3 4.0 33.4 6 3.8 33.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FAM60A PF15396.6 CDI74869.1 - 5.3 7.0 25.8 6.7 6.6 25.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Spore_coat_CotO PF14153.6 CDI74869.1 - 5.7 6.8 41.4 8.2 6.3 41.4 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Velvet PF11754.8 CDI74869.1 - 6 6.7 29.8 8.4 6.2 29.8 1.3 1 0 0 1 1 1 0 Velvet factor DUF2347 PF09804.9 CDI74869.1 - 7 6.1 15.1 8.3 5.9 15.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Endostatin PF06482.11 CDI74869.1 - 8.2 5.8 29.3 9.6 5.6 29.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Nop53 PF07767.11 CDI74869.1 - 8.5 5.6 38.6 9.5 5.5 38.6 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF5427 PF10310.9 CDI74869.1 - 8.9 5.1 33.9 11 4.9 33.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Presenilin PF01080.17 CDI74869.1 - 9 4.9 42.0 11 4.7 42.0 1.0 1 0 0 1 1 1 0 Presenilin zf-CCHH PF10283.9 CDI74871.1 - 0.24 11.4 2.1 0.61 10.1 1.6 2.0 2 0 0 2 2 2 0 PBZ domain Topoisom_I PF01028.20 CDI74871.1 - 0.3 10.3 1.8 0.47 9.7 1.8 1.2 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, catalytic core CTP_transf_like PF01467.26 CDI74872.1 - 0.013 15.7 0.0 0.035 14.3 0.0 1.7 2 0 0 2 2 2 0 Cytidylyltransferase-like NTP_transf_3 PF12804.7 CDI74873.1 - 2e-13 51.0 0.0 5.7e-13 49.5 0.0 1.8 1 1 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 CDI74873.1 - 6.4e-12 45.6 0.0 1.6e-11 44.3 0.0 1.6 1 1 0 1 1 1 1 Nucleotidyl transferase Fucokinase PF07959.12 CDI74873.1 - 9.5e-05 21.5 1.0 0.0025 16.8 0.2 1.7 1 1 1 2 2 2 2 L-fucokinase Hexapep PF00132.24 CDI74873.1 - 0.00015 21.3 0.1 0.63 9.9 0.0 2.7 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) CTP_transf_3 PF02348.19 CDI74873.1 - 0.14 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase DUF4954 PF16314.5 CDI74873.1 - 0.21 9.7 0.1 0.31 9.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) PepSY_TM PF03929.16 CDI74875.1 - 0.1 12.2 0.7 0.92 9.1 0.0 1.8 1 1 1 2 2 2 0 PepSY-associated TM region TPR_2 PF07719.17 CDI74876.1 - 0.00043 20.2 2.8 0.36 11.1 0.3 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDI74876.1 - 0.0026 17.5 1.0 0.99 9.3 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI74876.1 - 0.014 16.2 1.0 0.014 16.2 1.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat EphA2_TM PF14575.6 CDI74877.1 - 3.2e-06 27.9 6.9 1.3 10.0 0.1 5.4 5 0 0 5 5 5 2 Ephrin type-A receptor 2 transmembrane domain SARAF PF06682.12 CDI74877.1 - 0.0044 16.7 7.1 0.0044 16.7 7.1 3.9 2 2 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis RskA PF10099.9 CDI74877.1 - 0.0084 16.4 0.3 0.0084 16.4 0.3 7.5 2 2 2 4 4 4 1 Anti-sigma-K factor rskA DUF1043 PF06295.12 CDI74877.1 - 0.015 15.3 1.2 0.015 15.3 1.2 4.6 5 0 0 5 5 5 0 Protein of unknown function (DUF1043) LapA_dom PF06305.11 CDI74877.1 - 0.094 12.5 0.2 0.094 12.5 0.2 4.4 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain A_deaminase_N PF08451.11 CDI74877.1 - 1.3 9.4 4.7 6.1 7.2 0.2 2.9 2 0 0 2 2 2 0 Adenosine/AMP deaminase N-terminal V_ATPase_I PF01496.19 CDI74877.1 - 6.4 4.6 13.4 0.37 8.6 1.9 2.9 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family SR-25 PF10500.9 CDI74878.1 - 1.9e-05 24.4 18.9 2.3e-05 24.1 18.9 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Menin PF05053.13 CDI74878.1 - 0.25 9.6 17.4 0.28 9.5 17.4 1.0 1 0 0 1 1 1 0 Menin Macoilin PF09726.9 CDI74878.1 - 0.51 8.8 23.0 0.67 8.4 23.0 1.2 1 0 0 1 1 1 0 Macoilin family Neur_chan_memb PF02932.16 CDI74878.1 - 0.61 10.1 21.2 0.75 9.8 21.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PA26 PF04636.13 CDI74878.1 - 0.73 8.7 18.8 1 8.2 18.8 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF5523 PF17661.1 CDI74878.1 - 0.73 9.5 20.7 1 9.0 20.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Cwf_Cwc_15 PF04889.12 CDI74878.1 - 0.77 9.5 21.0 1 9.0 21.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 CDI74878.1 - 0.78 8.0 17.6 0.9 7.8 17.6 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF1387 PF07139.11 CDI74878.1 - 1.2 8.8 25.2 1.7 8.3 25.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) LAP1C PF05609.12 CDI74878.1 - 1.4 7.9 25.2 1.6 7.8 25.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Nop53 PF07767.11 CDI74878.1 - 1.7 7.9 25.7 2.5 7.4 25.7 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) ASD2 PF08687.11 CDI74878.1 - 2.8 7.4 26.5 3.7 7.0 26.5 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 PPP4R2 PF09184.11 CDI74878.1 - 3 7.3 20.8 3.8 7.0 20.8 1.1 1 0 0 1 1 1 0 PPP4R2 CrgA PF06781.12 CDI74878.1 - 3.5 7.8 6.5 1.2 9.2 0.5 2.3 2 0 0 2 2 2 0 Cell division protein CrgA DUF4551 PF15087.6 CDI74878.1 - 4 6.1 24.9 4.8 5.9 24.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) MID_MedPIWI PF18296.1 CDI74878.1 - 4.5 7.0 27.6 6 6.6 27.6 1.1 1 0 0 1 1 1 0 MID domain of medPIWI Caldesmon PF02029.15 CDI74878.1 - 5 5.8 26.6 6.2 5.5 26.6 1.1 1 0 0 1 1 1 0 Caldesmon IMUP PF15761.5 CDI74878.1 - 5.2 7.8 16.0 14 6.4 16.0 1.7 1 1 0 1 1 1 0 Immortalisation up-regulated protein Presenilin PF01080.17 CDI74878.1 - 7.1 5.3 32.3 8.3 5.1 32.3 1.1 1 0 0 1 1 1 0 Presenilin SWIB PF02201.18 CDI74881.1 - 8.8e-23 80.0 0.1 1.3e-22 79.4 0.1 1.3 1 0 0 1 1 1 1 SWIB/MDM2 domain TFIIA PF03153.13 CDI74881.1 - 0.24 11.4 18.3 0.34 10.8 18.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI74881.1 - 0.34 10.5 17.6 0.7 9.5 14.4 2.1 2 0 0 2 2 2 0 Spt20 family SR-25 PF10500.9 CDI74881.1 - 0.41 10.2 22.3 0.022 14.4 13.3 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF3123 PF11321.8 CDI74881.1 - 6.3 7.5 21.9 0.42 11.3 4.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) Isy1 PF06246.12 CDI74883.1 - 8.4 5.9 29.8 1.4 8.5 3.4 3.2 3 0 0 3 3 3 0 Isy1-like splicing family RAP1 PF07218.11 CDI74884.1 - 1.7 6.8 6.8 2.1 6.5 6.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Slu7 PF11708.8 CDI74884.1 - 1.8 8.3 37.5 2.1 8.0 12.6 2.2 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor DUF2722 PF10846.8 CDI74885.1 - 4.6e-05 22.6 14.2 5.8e-05 22.2 14.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) NST1 PF13945.6 CDI74885.1 - 0.00036 20.7 10.7 0.00047 20.3 10.7 1.1 1 0 0 1 1 1 1 Salt tolerance down-regulator Ephrin_rec_like PF07699.13 CDI74885.1 - 0.0021 17.8 2.4 0.0069 16.1 2.4 2.0 1 0 0 1 1 1 1 Putative ephrin-receptor like SpoIIP PF07454.11 CDI74885.1 - 0.0026 17.2 5.6 0.0029 17.1 5.6 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) EPL1 PF10513.9 CDI74885.1 - 0.0028 18.0 4.8 0.003 17.9 4.8 1.2 1 0 0 1 1 1 1 Enhancer of polycomb-like CDC45 PF02724.14 CDI74885.1 - 0.0036 15.7 0.5 0.0036 15.7 0.5 1.0 1 0 0 1 1 1 1 CDC45-like protein RR_TM4-6 PF06459.12 CDI74885.1 - 0.0047 16.8 5.5 0.0051 16.7 5.5 1.2 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI74885.1 - 0.0059 15.4 7.3 0.0059 15.4 7.3 1.1 1 0 0 1 1 1 1 Presenilin MMR1 PF08505.10 CDI74885.1 - 0.0071 16.7 7.7 0.0073 16.6 7.7 1.2 1 0 0 1 1 1 1 Mitochondrial Myo2 receptor-related protein Peroxin-13_N PF04088.13 CDI74885.1 - 0.0075 16.5 3.8 0.013 15.8 3.8 1.3 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SLC12 PF03522.15 CDI74885.1 - 0.0094 15.0 3.5 0.0088 15.1 3.5 1.1 1 0 0 1 1 1 1 Solute carrier family 12 RLL PF10036.9 CDI74885.1 - 0.0094 15.8 14.5 0.011 15.6 14.5 1.1 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein Band_3_cyto PF07565.13 CDI74885.1 - 0.012 15.5 5.2 0.013 15.4 5.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4366 PF14283.6 CDI74885.1 - 0.013 15.6 4.6 0.013 15.6 4.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) DUF4770 PF15994.5 CDI74885.1 - 0.015 15.6 7.2 0.016 15.5 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Orf78 PF06024.12 CDI74885.1 - 0.016 15.5 4.7 0.028 14.7 4.7 1.4 1 0 0 1 1 1 0 Orf78 (ac78) PBP1_TM PF14812.6 CDI74885.1 - 0.016 15.5 1.3 0.026 14.9 1.3 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Gti1_Pac2 PF09729.9 CDI74885.1 - 0.019 15.1 2.0 0.02 15.0 2.0 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Lin-8 PF03353.15 CDI74885.1 - 0.021 14.4 8.4 0.023 14.3 8.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CSG2 PF16965.5 CDI74885.1 - 0.024 13.6 1.4 0.031 13.2 1.4 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Connexin PF00029.19 CDI74885.1 - 0.026 14.3 5.2 0.031 14.1 5.2 1.1 1 0 0 1 1 1 0 Connexin DUF2828 PF11443.8 CDI74885.1 - 0.03 12.4 5.3 0.032 12.3 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4834 PF16118.5 CDI74885.1 - 0.043 14.8 9.3 0.076 14.0 9.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Consortin_C PF15281.6 CDI74885.1 - 0.045 13.7 2.1 0.068 13.2 2.1 1.2 1 0 0 1 1 1 0 Consortin C-terminus MDM10 PF12519.8 CDI74885.1 - 0.069 12.0 4.2 0.076 11.9 4.2 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Neur_chan_memb PF02932.16 CDI74885.1 - 0.083 12.9 4.2 0.09 12.8 4.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI74885.1 - 0.086 11.7 3.8 0.09 11.6 3.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM176 PF14851.6 CDI74885.1 - 0.086 12.5 1.0 0.11 12.1 1.0 1.3 1 0 0 1 1 1 0 FAM176 family Otopetrin PF03189.13 CDI74885.1 - 0.089 11.6 0.6 0.093 11.5 0.6 1.1 1 0 0 1 1 1 0 Otopetrin Zip PF02535.22 CDI74885.1 - 0.097 11.9 0.8 0.1 11.8 0.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter BatD PF13584.6 CDI74885.1 - 0.097 11.5 10.4 0.11 11.2 10.4 1.1 1 0 0 1 1 1 0 Oxygen tolerance Hid1 PF12722.7 CDI74885.1 - 0.12 10.5 4.6 0.12 10.5 4.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PAT1 PF09770.9 CDI74885.1 - 0.14 10.4 18.9 0.16 10.2 18.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ni_hydr_CYTB PF01292.20 CDI74885.1 - 0.15 11.7 0.4 0.17 11.4 0.4 1.2 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 CD20 PF04103.15 CDI74885.1 - 0.17 12.0 0.2 0.17 12.0 0.2 1.6 2 0 0 2 2 1 0 CD20-like family OATP PF03137.20 CDI74885.1 - 0.22 9.8 4.1 0.26 9.5 4.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Plasmodium_Vir PF05795.11 CDI74885.1 - 0.24 10.8 3.6 0.25 10.7 3.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RICTOR_N PF14664.6 CDI74885.1 - 0.26 10.3 4.8 0.32 9.9 4.8 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term DUF4045 PF13254.6 CDI74885.1 - 0.28 10.8 11.9 0.34 10.5 11.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) HGTP_anticodon2 PF12745.7 CDI74885.1 - 0.29 10.6 9.9 0.47 9.9 9.9 1.2 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs EOS1 PF12326.8 CDI74885.1 - 0.31 11.0 2.6 0.41 10.5 2.6 1.2 1 0 0 1 1 1 0 N-glycosylation protein HCO3_cotransp PF00955.21 CDI74885.1 - 0.31 9.8 1.9 0.38 9.5 1.9 1.1 1 0 0 1 1 1 0 HCO3- transporter family EIIBC-GUT_N PF03612.14 CDI74885.1 - 0.33 10.7 10.3 0.57 9.9 10.3 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus FAM91_C PF14648.6 CDI74885.1 - 0.41 9.4 5.3 0.54 9.0 5.3 1.1 1 0 0 1 1 1 0 FAM91 C-terminus RBP_receptor PF14752.6 CDI74885.1 - 0.41 9.1 9.5 0.53 8.8 9.5 1.1 1 0 0 1 1 1 0 Retinol binding protein receptor CLN3 PF02487.17 CDI74885.1 - 0.49 9.4 6.2 0.64 9.0 6.2 1.1 1 0 0 1 1 1 0 CLN3 protein Paramyxo_ncap PF00973.19 CDI74885.1 - 0.5 9.2 4.3 0.55 9.1 4.3 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein THOC2_N PF16134.5 CDI74885.1 - 0.51 8.9 11.3 0.76 8.3 11.3 1.2 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus ABC2_membrane_3 PF12698.7 CDI74885.1 - 0.6 9.1 1.8 0.79 8.8 1.8 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein MDM31_MDM32 PF08118.11 CDI74885.1 - 0.76 8.4 6.4 0.99 8.0 6.4 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Peptidase_S49_N PF08496.10 CDI74885.1 - 0.83 9.7 10.2 1.2 9.2 10.2 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4199 PF13858.6 CDI74885.1 - 0.96 9.8 2.9 1.4 9.3 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) SWI-SNF_Ssr4 PF08549.10 CDI74885.1 - 1 8.0 14.8 1.5 7.4 14.8 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) GNAT_acetyltr_2 PF13718.6 CDI74885.1 - 1.1 8.6 7.9 1.6 8.1 7.9 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Serinc PF03348.15 CDI74885.1 - 1.2 8.0 5.2 1.5 7.7 5.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) MCU PF04678.13 CDI74885.1 - 1.3 9.1 7.5 1.9 8.6 7.5 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter GET2 PF08690.10 CDI74885.1 - 1.4 8.6 15.0 0.89 9.2 13.8 1.4 1 1 0 1 1 1 0 GET complex subunit GET2 Glt_symporter PF03616.14 CDI74885.1 - 1.5 7.4 3.8 2.3 6.8 3.8 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter PIP5K PF01504.18 CDI74885.1 - 1.7 7.8 10.8 2.3 7.4 10.8 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Folate_carrier PF01770.18 CDI74885.1 - 1.9 7.1 5.9 2.7 6.7 5.9 1.1 1 0 0 1 1 1 0 Reduced folate carrier UPF0560 PF10577.9 CDI74885.1 - 3.2 6.1 16.6 3.9 5.9 16.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Sec62 PF03839.16 CDI74885.1 - 3.4 7.1 8.9 4.8 6.6 8.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 V_ATPase_I PF01496.19 CDI74885.1 - 3.6 5.4 13.0 4.7 5.0 13.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family G0-G1_switch_2 PF15103.6 CDI74885.1 - 3.6 8.1 9.9 6.5 7.2 9.9 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 DUF2347 PF09804.9 CDI74885.1 - 3.6 7.1 6.9 4.8 6.7 6.9 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) ABC2_membrane_2 PF12679.7 CDI74885.1 - 3.6 6.8 10.2 5.1 6.3 10.2 1.3 1 1 0 1 1 1 0 ABC-2 family transporter protein PigN PF04987.14 CDI74885.1 - 3.6 6.3 7.9 4.7 6.0 7.9 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) DUF3405 PF11885.8 CDI74885.1 - 3.7 6.0 9.5 5 5.6 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) Ndc1_Nup PF09531.10 CDI74885.1 - 4.1 6.0 17.6 5.1 5.7 17.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AUX_IAA PF02309.16 CDI74885.1 - 5.1 6.9 8.8 6.5 6.5 8.8 1.1 1 0 0 1 1 1 0 AUX/IAA family GREB1 PF15782.5 CDI74885.1 - 5.9 3.9 13.2 6.5 3.7 13.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ORC_WH_C PF18137.1 CDI74885.1 - 6.1 6.9 12.8 12 5.9 12.8 1.4 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Rxt3 PF08642.10 CDI74885.1 - 6.9 7.5 12.4 6.8 7.5 11.4 1.5 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 HNOBA PF07701.14 CDI74885.1 - 8.4 5.8 13.8 12 5.2 13.8 1.1 1 0 0 1 1 1 0 Heme NO binding associated Membralin PF09746.9 CDI74885.1 - 9.4 5.2 8.0 12 4.8 8.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein CobT PF06213.12 CDI74886.1 - 0.019 14.4 40.8 0.022 14.2 40.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 CDI74886.1 - 0.17 10.6 38.0 0.18 10.5 38.0 1.1 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 CDI74886.1 - 0.22 9.9 12.9 0.25 9.7 12.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 AMP-binding PF00501.28 CDI74886.1 - 0.38 9.3 10.3 0.42 9.1 10.3 1.0 1 0 0 1 1 1 0 AMP-binding enzyme Endostatin PF06482.11 CDI74886.1 - 0.41 10.1 25.5 0.45 9.9 25.5 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin RR_TM4-6 PF06459.12 CDI74886.1 - 0.49 10.2 33.8 0.54 10.0 33.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 CDI74886.1 - 0.81 8.6 20.4 0.84 8.5 20.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) V_ATPase_I PF01496.19 CDI74886.1 - 0.94 7.3 28.5 0.91 7.4 28.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SelP_N PF04592.14 CDI74886.1 - 1 8.7 26.8 1.1 8.6 26.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Miga PF10265.9 CDI74886.1 - 1.8 7.4 21.3 2.1 7.3 21.3 1.1 1 0 0 1 1 1 0 Mitoguardin SAPS PF04499.15 CDI74886.1 - 4 6.1 23.4 4.2 6.1 23.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein GAGA_bind PF06217.12 CDI74886.1 - 4 7.6 26.1 4.2 7.6 26.1 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family ADP_ribosyl_GH PF03747.14 CDI74886.1 - 4.8 6.8 14.6 5.7 6.6 14.6 1.1 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase Neur_chan_memb PF02932.16 CDI74886.1 - 6.3 6.8 28.4 6.9 6.7 28.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4746 PF15928.5 CDI74886.1 - 6.4 6.1 23.0 7.3 5.9 23.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF2828 PF11443.8 CDI74886.1 - 6.5 4.7 28.5 6.8 4.7 28.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) ALMT PF11744.8 CDI74886.1 - 6.6 5.4 25.6 6.6 5.4 25.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter VIR_N PF15912.5 CDI74886.1 - 6.7 6.2 18.7 7 6.2 18.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DUF2052 PF09747.9 CDI74886.1 - 7.4 6.6 33.8 8.4 6.5 33.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CCSAP PF15748.5 CDI74886.1 - 8.3 6.5 39.3 9.9 6.3 39.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 CDI74886.1 - 8.6 5.3 34.1 8.9 5.2 34.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 BORG_CEP PF14957.6 CDI74886.1 - 8.9 7.5 22.4 11 7.2 22.4 1.2 1 0 0 1 1 1 0 Cdc42 effector O-antigen_lig PF13425.6 CDI74886.1 - 9.1 4.9 15.5 9.5 4.9 15.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RskA PF10099.9 CDI74888.1 - 0.0025 18.2 1.0 0.0025 18.2 1.0 2.7 1 1 1 2 2 2 1 Anti-sigma-K factor rskA DUF853 PF05872.12 CDI74888.1 - 1.3 7.5 10.9 2.2 6.8 10.9 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) AAA_21 PF13304.6 CDI74888.1 - 2.9 7.6 13.0 3.7 7.3 13.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF4834 PF16118.5 CDI74889.1 - 0.00019 22.4 14.9 0.00019 22.4 14.9 2.8 1 1 1 2 2 1 1 Domain of unknown function (DUF4834) DUF1980 PF09323.10 CDI74889.1 - 0.00039 20.4 10.6 0.00039 20.4 10.6 2.0 1 1 1 2 2 1 1 Domain of unknown function (DUF1980) Zip PF02535.22 CDI74889.1 - 0.00049 19.4 15.0 0.0006 19.1 15.0 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter SpoIIIAH PF12685.7 CDI74889.1 - 0.00063 19.6 29.7 0.00088 19.2 29.7 1.1 1 0 0 1 1 1 1 SpoIIIAH-like protein LYRIC PF15686.5 CDI74889.1 - 0.00073 19.2 20.0 0.00083 19.0 20.0 1.0 1 0 0 1 1 1 1 Lysine-rich CEACAM1 co-isolated protein family DUF3332 PF11810.8 CDI74889.1 - 0.0021 17.8 8.9 0.0023 17.6 8.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3332) Neur_chan_memb PF02932.16 CDI74889.1 - 0.0087 16.2 21.5 0.011 15.8 21.5 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI74889.1 - 0.021 13.6 46.3 0.025 13.3 46.3 1.1 1 0 0 1 1 1 0 Presenilin O-antigen_lig PF13425.6 CDI74889.1 - 0.071 11.9 16.5 0.1 11.4 16.5 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SLC12 PF03522.15 CDI74889.1 - 0.6 9.1 38.6 0.65 9.0 38.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SelP_N PF04592.14 CDI74889.1 - 0.65 9.3 28.1 0.97 8.8 28.1 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region KASH PF10541.9 CDI74889.1 - 1.2 9.4 6.5 1.8 8.9 6.5 1.3 1 0 0 1 1 1 0 Nuclear envelope localisation domain SID-1_RNA_chan PF13965.6 CDI74889.1 - 3.2 6.0 26.1 11 4.3 26.1 1.7 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 CCSAP PF15748.5 CDI74889.1 - 3.6 7.7 48.4 4.6 7.3 48.4 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Hid1 PF12722.7 CDI74889.1 - 3.9 5.5 38.5 4.2 5.4 38.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PA26 PF04636.13 CDI74889.1 - 4.6 6.1 27.9 5.5 5.8 27.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Membralin PF09746.9 CDI74889.1 - 6.8 5.6 25.8 8.7 5.3 25.8 1.2 1 0 0 1 1 1 0 Tumour-associated protein BatA PF07584.11 CDI74890.1 - 0.047 14.0 7.9 0.65 10.4 1.4 2.3 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal DUF418 PF04235.12 CDI74890.1 - 0.82 9.6 5.6 3.5 7.5 5.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF418) DUF1180 PF06679.12 CDI74890.1 - 4.4 7.7 15.6 2.5 8.5 6.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1180) DUF3100 PF11299.8 CDI74890.1 - 4.5 6.6 10.2 4 6.8 7.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3100) SR-25 PF10500.9 CDI74891.1 - 0.0015 18.2 20.5 0.0015 18.2 20.5 5.3 4 1 2 6 6 6 4 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI74892.1 - 0.1 12.6 30.7 0.13 12.2 30.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hamartin PF04388.12 CDI74892.1 - 1.4 7.4 33.4 1.8 7.1 33.4 1.0 1 0 0 1 1 1 0 Hamartin protein Utp14 PF04615.13 CDI74892.1 - 7.7 5.0 33.9 9.3 4.7 33.9 1.0 1 0 0 1 1 1 0 Utp14 protein DUF2722 PF10846.8 CDI74893.1 - 0.0092 15.0 23.5 0.0091 15.0 23.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI74893.1 - 0.023 15.4 11.4 0.02 15.5 11.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Methyltransf_32 PF13679.6 CDI74893.1 - 0.033 14.2 8.3 0.038 14.0 8.3 1.1 1 0 0 1 1 1 0 Methyltransferase domain Rol_Rep_N PF18106.1 CDI74893.1 - 0.067 13.5 3.4 0.076 13.3 3.4 1.1 1 0 0 1 1 1 0 Rolling Circle replication initiation protein N-terminal domain Spt20 PF12090.8 CDI74893.1 - 0.068 12.8 29.7 0.07 12.7 29.7 1.1 1 0 0 1 1 1 0 Spt20 family MIT_LIKE_ACTX PF17556.2 CDI74893.1 - 0.08 13.6 4.9 0.8 10.3 4.9 2.0 1 1 0 1 1 1 0 MIT-like atracotoxin family Orf78 PF06024.12 CDI74893.1 - 0.18 12.1 5.8 0.23 11.8 5.8 1.1 1 0 0 1 1 1 0 Orf78 (ac78) CobT PF06213.12 CDI74893.1 - 0.18 11.1 12.5 0.18 11.1 12.5 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TFIIA PF03153.13 CDI74893.1 - 0.25 11.3 24.8 0.23 11.4 24.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Asparaginase_2 PF01112.18 CDI74893.1 - 0.27 10.2 3.6 0.29 10.1 3.6 1.0 1 0 0 1 1 1 0 Asparaginase FAM176 PF14851.6 CDI74893.1 - 0.3 10.7 6.4 0.33 10.6 6.4 1.1 1 0 0 1 1 1 0 FAM176 family Peptidase_S49_N PF08496.10 CDI74893.1 - 0.36 10.9 6.4 0.42 10.7 6.4 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Tim54 PF11711.8 CDI74893.1 - 0.44 9.3 6.7 0.41 9.4 6.7 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PIP5K PF01504.18 CDI74893.1 - 0.47 9.6 6.6 0.49 9.6 6.6 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF4834 PF16118.5 CDI74893.1 - 0.48 11.4 11.9 0.53 11.3 11.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) PEX11 PF05648.14 CDI74893.1 - 0.5 9.8 5.2 0.53 9.7 5.2 1.1 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) WASH-7_C PF14746.6 CDI74893.1 - 0.5 10.0 10.0 0.57 9.9 10.0 1.0 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal Suf PF05843.14 CDI74893.1 - 0.51 10.3 14.2 0.51 10.3 14.2 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SpoIIP PF07454.11 CDI74893.1 - 0.53 9.7 9.9 0.53 9.7 9.9 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) NEMP PF10225.9 CDI74893.1 - 0.56 9.8 7.3 0.59 9.8 7.3 1.0 1 0 0 1 1 1 0 NEMP family DUF2126 PF09899.9 CDI74893.1 - 0.6 8.1 6.7 0.63 8.0 6.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) TMEM51 PF15345.6 CDI74893.1 - 0.63 9.8 12.0 0.65 9.8 12.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 RR_TM4-6 PF06459.12 CDI74893.1 - 0.63 9.8 8.0 0.61 9.9 8.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Roughex PF06020.11 CDI74893.1 - 0.64 9.1 11.7 0.67 9.0 11.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF3371 PF11851.8 CDI74893.1 - 0.65 11.1 11.5 0.69 11.0 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) G0-G1_switch_2 PF15103.6 CDI74893.1 - 0.68 10.4 6.5 0.78 10.2 6.5 1.1 1 0 0 1 1 1 0 G0/G1 switch protein 2 Med15 PF09606.10 CDI74893.1 - 0.77 8.4 24.9 0.72 8.5 24.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CPSF100_C PF13299.6 CDI74893.1 - 0.85 9.8 7.9 0.91 9.7 7.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal eIF-3_zeta PF05091.12 CDI74893.1 - 0.86 8.5 12.8 0.82 8.6 12.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Sec62 PF03839.16 CDI74893.1 - 0.87 9.1 6.0 0.88 9.0 6.0 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 FHIPEP PF00771.20 CDI74893.1 - 0.97 7.8 6.5 0.99 7.8 6.5 1.0 1 0 0 1 1 1 0 FHIPEP family AIF_C PF14721.6 CDI74893.1 - 0.99 9.8 7.2 1.1 9.7 7.2 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Connexin PF00029.19 CDI74893.1 - 1 9.1 6.5 1.1 9.0 6.5 1.1 1 0 0 1 1 1 0 Connexin EIIBC-GUT_N PF03612.14 CDI74893.1 - 1.1 8.9 9.8 1.4 8.7 9.8 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 CDI74893.1 - 1.2 7.8 11.3 1.2 7.8 11.3 1.0 1 0 0 1 1 1 0 Presenilin TERB2 PF15101.6 CDI74893.1 - 1.3 9.1 14.4 1.4 9.0 14.4 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 FlaG PF03646.15 CDI74893.1 - 1.3 9.2 15.3 1.5 9.0 15.3 1.2 1 0 0 1 1 1 0 FlaG protein DUF3464 PF11947.8 CDI74893.1 - 1.4 8.7 10.0 1.7 8.4 10.0 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Ureide_permease PF07168.11 CDI74893.1 - 1.5 7.5 3.7 1.3 7.7 3.7 1.0 1 0 0 1 1 1 0 Ureide permease Folate_carrier PF01770.18 CDI74893.1 - 1.5 7.5 6.6 1.5 7.4 6.6 1.0 1 0 0 1 1 1 0 Reduced folate carrier DUF3043 PF11241.8 CDI74893.1 - 1.8 8.6 6.2 2 8.4 6.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF4407 PF14362.6 CDI74893.1 - 1.8 7.8 9.8 1.8 7.8 9.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DDHD PF02862.17 CDI74893.1 - 2 8.5 9.2 1.9 8.6 9.2 1.1 1 0 0 1 1 1 0 DDHD domain EPL1 PF10513.9 CDI74893.1 - 2 8.8 12.4 2.1 8.7 12.4 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like CLN3 PF02487.17 CDI74893.1 - 2.3 7.2 6.7 2.2 7.2 6.7 1.0 1 0 0 1 1 1 0 CLN3 protein VIT1 PF01988.19 CDI74893.1 - 2.4 8.0 4.1 2.4 7.9 4.1 1.1 1 0 0 1 1 1 0 VIT family Band_3_cyto PF07565.13 CDI74893.1 - 2.6 7.8 10.1 2.7 7.7 10.1 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SprA-related PF12118.8 CDI74893.1 - 2.7 7.1 21.6 2.6 7.1 21.6 1.1 1 0 0 1 1 1 0 SprA-related family DUF4770 PF15994.5 CDI74893.1 - 2.7 8.2 11.6 3 8.1 11.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) CSG2 PF16965.5 CDI74893.1 - 3.5 6.5 5.4 3.5 6.5 5.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Zip PF02535.22 CDI74893.1 - 3.6 6.7 6.1 3.7 6.7 6.1 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter EOS1 PF12326.8 CDI74893.1 - 3.6 7.5 6.0 3.6 7.5 6.0 1.1 1 0 0 1 1 1 0 N-glycosylation protein UPF0560 PF10577.9 CDI74893.1 - 3.9 5.8 16.1 3.9 5.9 16.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Androgen_recep PF02166.16 CDI74893.1 - 4.3 6.1 25.5 4.3 6.1 25.5 1.1 1 0 0 1 1 1 0 Androgen receptor Kei1 PF08552.11 CDI74893.1 - 4.7 7.1 6.2 4.6 7.1 6.2 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Ketoacyl-synt_2 PF13723.6 CDI74893.1 - 5 6.7 13.7 5.6 6.5 13.7 1.0 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain ALMT PF11744.8 CDI74893.1 - 5.4 5.7 7.8 5.6 5.7 7.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Glt_symporter PF03616.14 CDI74893.1 - 6 5.4 5.0 6.1 5.4 5.0 1.0 1 0 0 1 1 1 0 Sodium/glutamate symporter Pex26 PF07163.12 CDI74893.1 - 6.3 6.0 11.8 6.4 6.0 11.8 1.1 1 0 0 1 1 1 0 Pex26 protein Neur_chan_memb PF02932.16 CDI74893.1 - 6.8 6.7 9.6 6.6 6.7 9.6 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1980 PF09323.10 CDI74893.1 - 7.1 6.5 7.6 7.6 6.4 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Coilin_N PF15862.5 CDI74893.1 - 8 6.3 17.1 10 5.9 17.1 1.2 1 0 0 1 1 1 0 Coilin N-terminus DUF4199 PF13858.6 CDI74893.1 - 8.1 6.8 5.1 8.2 6.8 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF1682 PF07946.14 CDI74893.1 - 9.4 5.3 11.6 11 5.1 11.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DivIC PF04977.15 CDI74893.1 - 9.9 6.0 18.2 13 5.6 18.2 1.2 1 0 0 1 1 1 0 Septum formation initiator PB1 PF00564.24 CDI74894.1 - 0.094 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 PB1 domain DUF1772 PF08592.11 CDI74895.1 - 0.018 15.3 5.9 2 8.7 1.8 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) Macoilin PF09726.9 CDI74896.1 - 0.04 12.5 37.5 0.045 12.3 37.5 1.0 1 0 0 1 1 1 0 Macoilin family Asp-B-Hydro_N PF05279.11 CDI74896.1 - 3.5 7.6 16.6 3.9 7.5 16.6 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Cwf_Cwc_15 PF04889.12 CDI74896.1 - 6.1 6.5 31.4 7.6 6.2 31.4 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SRP-alpha_N PF04086.13 CDI74896.1 - 8 6.3 28.9 11 5.8 28.9 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Dicty_REP PF05086.12 CDI74896.1 - 8.9 4.2 24.4 11 3.8 24.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SR-25 PF10500.9 CDI74897.1 - 0.011 15.4 5.6 0.011 15.4 5.6 1.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein P_C10 PF14974.6 CDI74897.1 - 0.074 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein C10 Syntaphilin PF15290.6 CDI74897.1 - 3.8 7.1 8.0 6.4 6.3 8.0 1.3 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp SUZ PF12752.7 CDI74897.1 - 7.7 7.4 7.8 0.4 11.5 0.9 2.0 2 0 0 2 2 2 0 SUZ domain SUIM_assoc PF16619.5 CDI74898.1 - 0.00098 19.1 4.1 0.00098 19.1 4.1 9.3 5 2 2 7 7 7 2 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI74898.1 - 0.0035 17.7 1.2 0.0035 17.7 1.2 5.7 2 1 2 4 4 4 1 Anti-sigma-K factor rskA AAA PF00004.29 CDI74900.1 - 9.6e-15 55.2 0.0 1.9e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CDI74900.1 - 2.9e-14 53.2 0.0 1.4e-12 47.7 0.0 2.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 CDI74900.1 - 1.7e-05 25.1 0.0 0.00027 21.2 0.0 2.4 1 1 0 1 1 1 1 AAA domain Rep_fac_C PF08542.11 CDI74900.1 - 1.8e-05 25.1 0.5 6.1e-05 23.3 0.3 1.9 1 1 0 1 1 1 1 Replication factor C C-terminal domain AAA_assoc_2 PF16193.5 CDI74900.1 - 0.0001 22.6 1.0 0.00043 20.6 0.5 2.3 2 1 0 2 2 2 1 AAA C-terminal domain AAA_30 PF13604.6 CDI74900.1 - 0.0001 22.1 0.0 0.00027 20.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 CDI74900.1 - 0.00019 21.4 0.0 0.0004 20.4 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_19 PF13245.6 CDI74900.1 - 0.00022 21.6 0.2 0.0068 16.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 CDI74900.1 - 0.00052 19.8 0.3 0.0021 17.9 0.0 2.1 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CDI74900.1 - 0.00061 19.2 0.2 0.0031 16.9 0.0 2.3 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI KTI12 PF08433.10 CDI74900.1 - 0.00079 18.9 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 DUF2075 PF09848.9 CDI74900.1 - 0.0008 18.7 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.6 CDI74900.1 - 0.00081 19.4 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDI74900.1 - 0.00083 19.8 0.7 0.0072 16.7 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 CDI74900.1 - 0.00085 19.3 0.1 0.0047 16.9 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CDI74900.1 - 0.002 17.4 0.0 0.0039 16.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain DEAD PF00270.29 CDI74900.1 - 0.0052 16.6 0.0 0.85 9.4 0.0 2.5 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_18 PF13238.6 CDI74900.1 - 0.0067 17.0 0.0 0.013 16.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 CDI74900.1 - 0.0084 15.1 3.3 0.36 9.8 0.0 3.1 2 1 1 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_11 PF13086.6 CDI74900.1 - 0.016 15.0 0.0 0.043 13.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CDI74900.1 - 0.016 15.1 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 CDI74900.1 - 0.024 14.4 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDI74900.1 - 0.027 14.7 0.0 0.094 13.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CDI74900.1 - 0.03 14.5 0.1 0.066 13.4 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.14 CDI74900.1 - 0.039 14.1 0.0 0.13 12.4 0.0 1.8 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) ResIII PF04851.15 CDI74900.1 - 0.088 12.8 0.0 0.32 11.0 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit ATR13 PF16829.5 CDI74900.1 - 0.092 13.1 0.3 5.8 7.3 0.1 2.6 1 1 2 3 3 3 0 Avirulence protein ATR13, RxLR effector AAA_7 PF12775.7 CDI74900.1 - 0.11 12.0 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Spore_YhcN_YlaJ PF09580.10 CDI74901.1 - 0.46 10.6 0.0 0.46 10.6 0.0 7.0 4 3 1 5 5 5 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) RskA PF10099.9 CDI74903.1 - 7e-08 33.0 0.1 7e-08 33.0 0.1 4.8 1 1 1 3 3 3 1 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI74903.1 - 0.0014 17.7 30.2 0.0014 17.7 30.2 2.1 2 0 0 2 2 2 1 Transcriptional activator LAG-3 V_ATPase_I PF01496.19 CDI74904.1 - 5.3 4.8 20.2 7.5 4.3 20.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ECH_2 PF16113.5 CDI74905.1 - 7.9e-44 150.5 8.9 2.2e-22 80.0 0.0 4.0 2 1 2 4 4 4 3 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CDI74905.1 - 1.2e-11 44.4 15.6 1.6e-11 44.0 0.0 3.3 4 0 0 4 4 4 2 Enoyl-CoA hydratase/isomerase TFIIA PF03153.13 CDI74905.1 - 8e-06 26.1 41.1 0.0041 17.2 13.4 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI74905.1 - 0.00029 20.9 2.9 0.00029 20.9 2.9 4.5 2 2 0 2 2 1 1 Unstructured region C-term to UIM in Ataxin3 Apt1 PF10351.9 CDI74905.1 - 0.0033 16.3 11.2 0.0033 16.3 11.2 2.1 2 0 0 2 2 2 1 Golgi-body localisation protein domain Ndc1_Nup PF09531.10 CDI74905.1 - 0.043 12.5 21.9 0.14 10.8 8.8 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Spt20 PF12090.8 CDI74905.1 - 0.073 12.7 51.4 0.24 11.0 13.5 2.4 2 0 0 2 2 2 0 Spt20 family Med15 PF09606.10 CDI74905.1 - 0.32 9.6 39.4 0.46 9.1 13.8 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Macoilin PF09726.9 CDI74905.1 - 0.5 8.9 34.0 0.29 9.6 22.6 2.2 2 0 0 2 2 2 0 Macoilin family Pol_alpha_B_N PF08418.10 CDI74905.1 - 0.7 9.8 20.1 0.66 9.9 11.2 2.2 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal DUF4667 PF15700.5 CDI74905.1 - 2.8 8.0 37.4 4.6 7.3 26.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) PNISR PF15996.5 CDI74905.1 - 8.5 6.6 27.5 0.53 10.5 8.2 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR SPX PF03105.19 CDI74905.1 - 8.9 6.1 32.2 1.7 8.4 21.5 2.1 2 0 0 2 2 2 0 SPX domain Plasmodium_Vir PF05795.11 CDI74905.1 - 9.6 5.5 19.3 5.8 6.2 11.9 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein WD40 PF00400.32 CDI74906.1 - 0.00073 20.3 0.6 0.0049 17.7 0.1 2.6 2 0 0 2 2 2 1 WD domain, G-beta repeat PDGF_N PF04692.13 CDI74906.1 - 0.0037 18.0 5.0 0.0037 18.0 5.0 3.6 3 1 1 4 4 4 1 Platelet-derived growth factor, N terminal region TFIIA PF03153.13 CDI74906.1 - 1.4 8.8 24.7 1.9 8.4 24.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Utp14 PF04615.13 CDI74906.1 - 3 6.3 28.3 4 5.9 28.3 1.2 1 0 0 1 1 1 0 Utp14 protein GREB1 PF15782.5 CDI74906.1 - 4.2 4.4 26.3 4.9 4.1 26.3 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SUIM_assoc PF16619.5 CDI74908.1 - 0.014 15.4 3.9 0.014 15.4 3.9 12.0 5 3 3 8 8 8 0 Unstructured region C-term to UIM in Ataxin3 PI3K_1B_p101 PF10486.9 CDI74910.1 - 1 7.0 22.4 1.2 6.8 22.4 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF1645 PF07816.11 CDI74910.1 - 1.1 9.8 28.9 10 6.7 28.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1645) SR-25 PF10500.9 CDI74910.1 - 2.2 7.8 35.0 8.6 5.9 35.0 1.8 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein SLC12 PF03522.15 CDI74910.1 - 4.1 6.3 24.8 4.9 6.1 24.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Ndc1_Nup PF09531.10 CDI74910.1 - 5.7 5.5 28.5 6.6 5.3 28.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RAP1 PF07218.11 CDI74910.1 - 8.7 4.5 7.9 8.2 4.6 7.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Nucleoporin_FG PF13634.6 CDI74911.1 - 2.4e-05 25.1 34.5 2.4e-05 25.1 34.5 15.5 4 2 8 12 12 12 3 Nucleoporin FG repeat region PH_BEACH PF14844.6 CDI74911.1 - 0.048 13.8 2.8 0.28 11.3 2.8 2.4 1 0 0 1 1 1 0 PH domain associated with Beige/BEACH GET2 PF08690.10 CDI74914.1 - 0.83 9.3 4.9 5.9 6.5 5.7 1.8 2 0 0 2 2 2 0 GET complex subunit GET2 Pex14_N PF04695.13 CDI74914.1 - 0.97 10.1 10.1 0.054 14.2 4.8 1.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Vac7 PF12751.7 CDI74914.1 - 1 8.8 7.4 0.57 9.6 4.5 1.8 2 0 0 2 2 2 0 Vacuolar segregation subunit 7 Zip PF02535.22 CDI74914.1 - 1.2 8.3 2.6 1.7 7.8 2.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Suf PF05843.14 CDI74914.1 - 5.7 6.8 6.6 0.78 9.7 2.6 1.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Vfa1 PF08432.10 CDI74915.1 - 0.12 12.7 16.1 0.12 12.7 16.1 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 EMC3_TMCO1 PF01956.16 CDI74915.1 - 0.12 12.1 7.6 0.17 11.6 7.6 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Draxin PF15550.6 CDI74915.1 - 0.23 11.3 15.0 0.29 11.0 15.0 1.1 1 0 0 1 1 1 0 Draxin DUF2057 PF09829.9 CDI74915.1 - 3 8.0 13.2 3.6 7.7 13.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) Sec62 PF03839.16 CDI74915.1 - 3.3 7.2 11.6 3.7 7.0 11.6 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 AAA_13 PF13166.6 CDI74915.1 - 7.3 5.1 16.1 8.2 4.9 16.1 1.0 1 0 0 1 1 1 0 AAA domain CDC45 PF02724.14 CDI74915.1 - 7.9 4.6 10.8 8.2 4.6 10.8 1.0 1 0 0 1 1 1 0 CDC45-like protein SR-25 PF10500.9 CDI74917.1 - 0.033 13.8 35.8 0.49 10.0 11.0 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI74917.1 - 0.14 12.5 36.1 0.032 14.5 21.9 2.7 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Hamartin PF04388.12 CDI74917.1 - 0.36 9.4 26.7 0.38 9.4 26.7 1.1 1 0 0 1 1 1 0 Hamartin protein Macoilin PF09726.9 CDI74917.1 - 0.74 8.3 29.2 0.99 7.9 29.2 1.2 1 0 0 1 1 1 0 Macoilin family NICE-1 PF15845.5 CDI74917.1 - 0.78 10.6 10.6 0.31 11.8 3.5 2.4 2 0 0 2 2 2 0 Cysteine-rich C-terminal 1 family PAT1 PF09770.9 CDI74917.1 - 2.3 6.4 44.7 2.5 6.3 44.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LAP1C PF05609.12 CDI74917.1 - 3.4 6.6 33.5 3.7 6.5 33.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Dynactin_p62 PF05502.13 CDI74917.1 - 6.6 5.4 27.4 8.6 5.0 27.4 1.1 1 0 0 1 1 1 0 Dynactin p62 family STAC2_u1 PF16664.5 CDI74917.1 - 8.1 6.9 34.0 0.89 10.0 15.7 2.5 1 1 1 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 NAR2 PF16974.5 CDI74918.1 - 0.074 12.4 2.7 0.096 12.1 2.7 1.2 1 0 0 1 1 1 0 High-affinity nitrate transporter accessory CLN3 PF02487.17 CDI74918.1 - 0.11 11.5 6.0 0.14 11.2 6.0 1.1 1 0 0 1 1 1 0 CLN3 protein Neuregulin PF02158.15 CDI74918.1 - 0.13 11.6 15.7 0.14 11.4 15.7 1.1 1 0 0 1 1 1 0 Neuregulin intracellular region RR_TM4-6 PF06459.12 CDI74918.1 - 0.55 10.0 11.4 0.59 9.9 11.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 CDI74918.1 - 1.1 9.2 12.2 1.3 9.1 12.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region 2OG-FeII_Oxy_5 PF13759.6 CDI74918.1 - 1.7 9.1 8.6 0.35 11.3 4.0 1.8 1 1 1 2 2 2 0 Putative 2OG-Fe(II) oxygenase YfhO PF09586.10 CDI74918.1 - 2.3 6.4 10.4 2.2 6.4 10.4 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO ALMT PF11744.8 CDI74918.1 - 4.1 6.1 11.1 4.7 5.9 11.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM60A PF15396.6 CDI74918.1 - 7 6.6 12.5 8.7 6.3 12.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Rer1 PF03248.13 CDI74918.1 - 8.2 6.1 8.3 0.72 9.6 0.6 2.1 2 0 0 2 2 2 0 Rer1 family GAGA_bind PF06217.12 CDI74919.1 - 0.00041 20.7 8.3 0.00046 20.6 8.3 1.1 1 0 0 1 1 1 1 GAGA binding protein-like family CENP-N PF05238.13 CDI74919.1 - 0.0015 17.9 1.6 0.0015 17.9 1.6 1.2 1 0 0 1 1 1 1 Kinetochore protein CHL4 like Serinc PF03348.15 CDI74919.1 - 0.0025 16.8 3.2 0.003 16.5 3.2 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF3807 PF12720.7 CDI74919.1 - 0.003 17.9 12.0 0.0038 17.5 12.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3807) Vfa1 PF08432.10 CDI74919.1 - 0.0068 16.7 21.3 0.0094 16.3 21.3 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 DDHD PF02862.17 CDI74919.1 - 0.0096 16.1 2.6 0.011 15.9 2.6 1.2 1 0 0 1 1 1 1 DDHD domain EOS1 PF12326.8 CDI74919.1 - 0.021 14.8 0.4 0.024 14.6 0.4 1.3 1 0 0 1 1 1 0 N-glycosylation protein Connexin PF00029.19 CDI74919.1 - 0.022 14.5 13.7 0.029 14.1 13.7 1.1 1 0 0 1 1 1 0 Connexin RPOL_N PF14700.6 CDI74919.1 - 0.034 13.6 12.9 0.046 13.1 12.9 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal SID-1_RNA_chan PF13965.6 CDI74919.1 - 0.036 12.5 0.1 0.041 12.3 0.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PBP_sp32 PF07222.12 CDI74919.1 - 0.055 12.9 7.0 0.08 12.4 7.0 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF913 PF06025.12 CDI74919.1 - 0.088 11.8 2.7 0.1 11.5 2.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM176 PF14851.6 CDI74919.1 - 0.088 12.5 5.3 0.15 11.7 5.3 1.3 1 0 0 1 1 1 0 FAM176 family Neur_chan_memb PF02932.16 CDI74919.1 - 0.1 12.6 1.0 0.12 12.5 1.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RPA43_OB PF17875.1 CDI74919.1 - 0.11 13.1 6.1 0.17 12.5 6.1 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I OATP PF03137.20 CDI74919.1 - 0.12 10.7 7.3 0.21 9.8 7.3 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family EIIBC-GUT_N PF03612.14 CDI74919.1 - 0.14 11.9 8.7 0.21 11.3 8.7 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Paramyxo_ncap PF00973.19 CDI74919.1 - 0.15 11.0 4.8 0.18 10.7 4.8 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Misat_Tub_SegII PF10644.9 CDI74919.1 - 0.15 12.3 6.0 0.24 11.7 6.0 1.2 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain Peptidase_S49_N PF08496.10 CDI74919.1 - 0.18 11.8 29.8 0.46 10.5 29.8 1.8 1 1 0 1 1 1 0 Peptidase family S49 N-terminal RR_TM4-6 PF06459.12 CDI74919.1 - 0.19 11.6 16.2 0.24 11.2 16.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4471 PF14740.6 CDI74919.1 - 0.2 10.9 9.6 0.28 10.4 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) Band_3_cyto PF07565.13 CDI74919.1 - 0.21 11.4 4.6 0.3 10.9 4.6 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SpoIIP PF07454.11 CDI74919.1 - 0.22 10.9 13.6 0.3 10.5 13.6 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) HSNSD PF12062.8 CDI74919.1 - 0.27 9.9 4.7 0.34 9.6 4.7 1.1 1 0 0 1 1 1 0 heparan sulfate-N-deacetylase DUF2828 PF11443.8 CDI74919.1 - 0.29 9.2 14.2 0.44 8.6 14.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) V_ATPase_I PF01496.19 CDI74919.1 - 0.31 8.9 9.9 0.4 8.5 9.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TFB6 PF17110.5 CDI74919.1 - 0.37 10.5 6.3 0.51 10.1 6.3 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Pex24p PF06398.11 CDI74919.1 - 0.38 9.7 4.8 0.51 9.3 4.8 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DDRGK PF09756.9 CDI74919.1 - 0.51 9.9 27.4 0.64 9.6 27.4 1.1 1 0 0 1 1 1 0 DDRGK domain PcfK PF14058.6 CDI74919.1 - 0.55 10.5 23.1 0.8 10.0 23.1 1.2 1 0 0 1 1 1 0 PcfK-like protein AIF_C PF14721.6 CDI74919.1 - 0.57 10.5 8.8 1 9.7 8.8 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term LicD PF04991.13 CDI74919.1 - 0.58 10.3 12.6 0.75 9.9 12.6 1.1 1 0 0 1 1 1 0 LicD family P5-ATPase PF12409.8 CDI74919.1 - 0.68 10.1 5.0 1.1 9.4 5.0 1.3 1 0 0 1 1 1 0 P5-type ATPase cation transporter DUF3405 PF11885.8 CDI74919.1 - 0.91 8.0 8.7 1.2 7.7 8.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) MDM10 PF12519.8 CDI74919.1 - 0.93 8.3 7.7 1.4 7.7 7.7 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 ORC_WH_C PF18137.1 CDI74919.1 - 1.2 9.2 13.7 2 8.5 13.7 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Rtf2 PF04641.12 CDI74919.1 - 1.3 8.4 22.2 2.1 7.6 22.2 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Peroxin-13_N PF04088.13 CDI74919.1 - 1.3 9.3 9.5 2.5 8.4 9.5 1.4 1 0 0 1 1 1 0 Peroxin 13, N-terminal region GNAT_acetyltr_2 PF13718.6 CDI74919.1 - 1.3 8.3 7.8 1.8 7.9 7.8 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 CSG2 PF16965.5 CDI74919.1 - 1.5 7.7 3.7 2.1 7.2 3.7 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Afi1 PF07792.12 CDI74919.1 - 1.8 9.0 11.3 2.7 8.5 11.3 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PDCD2_C PF04194.13 CDI74919.1 - 1.9 8.5 11.8 2.7 8.1 11.8 1.1 1 0 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain MAS20 PF02064.15 CDI74919.1 - 2.1 8.4 17.3 7 6.8 17.3 2.0 1 0 0 1 1 1 0 MAS20 protein import receptor MDM31_MDM32 PF08118.11 CDI74919.1 - 2.5 6.7 7.3 3.2 6.3 7.3 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF4770 PF15994.5 CDI74919.1 - 2.6 8.3 14.9 4.5 7.5 14.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) PPL5 PF18168.1 CDI74919.1 - 2.8 7.2 13.4 4.4 6.5 13.4 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF2228 PF10228.9 CDI74919.1 - 3 7.5 13.6 4 7.1 13.6 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) NPR3 PF03666.13 CDI74919.1 - 4.3 6.0 17.0 6 5.5 17.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Tim54 PF11711.8 CDI74919.1 - 4.4 6.0 18.3 6.2 5.5 18.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 MCM_bind PF09739.9 CDI74919.1 - 7.1 4.9 11.9 9.6 4.5 11.9 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor FancD2 PF14631.6 CDI74919.1 - 7.1 3.9 13.0 8.4 3.6 13.0 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Cellulose_synt PF03552.14 CDI74919.1 - 7.9 4.8 8.8 10 4.4 8.8 1.1 1 0 0 1 1 1 0 Cellulose synthase Eapp_C PF10238.9 CDI74919.1 - 9.3 6.3 17.4 15 5.7 17.4 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein Sec62 PF03839.16 CDI74919.1 - 9.6 5.6 21.6 16 4.9 21.6 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DAGK_prokar PF01219.19 CDI74920.1 - 0.056 13.3 0.0 0.056 13.3 0.0 2.1 1 1 1 2 2 2 0 Prokaryotic diacylglycerol kinase ThiJ_like PF17124.5 CDI74920.1 - 0.073 12.8 0.2 0.092 12.4 0.2 1.3 1 0 0 1 1 1 0 ThiJ/PfpI family-like Adeno_PV PF03910.13 CDI74920.1 - 0.16 10.7 3.8 0.15 10.8 3.8 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV DUF3138 PF11336.8 CDI74920.1 - 1.1 7.8 7.7 1.2 7.6 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) RuvC_III PF18541.1 CDI74921.1 - 0.059 13.3 7.9 0.086 12.8 7.9 1.2 1 0 0 1 1 1 0 RuvC endonuclease subdomain 3 Roughex PF06020.11 CDI74921.1 - 0.18 10.9 9.2 0.2 10.7 9.2 1.1 1 0 0 1 1 1 0 Drosophila roughex protein CPSF100_C PF13299.6 CDI74921.1 - 0.19 11.9 9.9 0.26 11.5 9.9 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 CDI74921.1 - 0.21 10.3 11.4 0.25 10.0 11.3 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 CDI74921.1 - 0.28 10.1 6.7 0.34 9.8 6.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Pex14_N PF04695.13 CDI74921.1 - 0.3 11.7 11.4 0.39 11.4 11.4 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Folliculin PF11704.8 CDI74921.1 - 0.33 10.8 7.6 0.42 10.5 7.6 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DDHD PF02862.17 CDI74921.1 - 0.34 11.0 8.0 0.4 10.8 8.0 1.1 1 0 0 1 1 1 0 DDHD domain SpoIIP PF07454.11 CDI74921.1 - 0.36 10.2 11.0 0.46 9.9 11.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RR_TM4-6 PF06459.12 CDI74921.1 - 0.41 10.4 13.7 0.48 10.2 13.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PBP1_TM PF14812.6 CDI74921.1 - 0.44 10.9 7.8 1 9.8 7.8 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 CDI74921.1 - 0.61 9.7 8.7 0.86 9.3 8.7 1.2 1 0 0 1 1 1 0 FAM176 family Bro-N PF02498.17 CDI74921.1 - 0.67 10.7 4.7 1.3 9.8 4.7 1.5 1 1 0 1 1 1 0 BRO family, N-terminal domain ALMT PF11744.8 CDI74921.1 - 0.98 8.2 11.0 1.3 7.8 11.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 CDI74921.1 - 1.2 7.3 13.6 1.4 7.1 13.6 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.6 CDI74921.1 - 1.4 8.9 8.7 1.8 8.6 8.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Zip PF02535.22 CDI74921.1 - 1.6 7.9 5.8 1.9 7.7 5.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter TERB2 PF15101.6 CDI74921.1 - 1.7 8.6 11.8 2.3 8.2 11.8 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Coilin_N PF15862.5 CDI74921.1 - 1.9 8.3 13.5 2.8 7.7 13.5 1.3 1 0 0 1 1 1 0 Coilin N-terminus DUF1980 PF09323.10 CDI74921.1 - 1.9 8.4 5.1 2.3 8.1 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF2058 PF09831.9 CDI74921.1 - 2.3 8.3 20.9 3.1 7.9 20.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) CobT PF06213.12 CDI74921.1 - 3 7.2 18.4 3.8 6.8 18.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Connexin PF00029.19 CDI74921.1 - 3.6 7.3 8.8 4.8 6.9 8.8 1.1 1 0 0 1 1 1 0 Connexin CSG2 PF16965.5 CDI74921.1 - 4.1 6.3 5.7 5 6.0 5.7 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator V_ATPase_I PF01496.19 CDI74921.1 - 5.2 4.9 10.3 5.7 4.7 10.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Neur_chan_memb PF02932.16 CDI74921.1 - 5.4 7.0 11.8 7 6.6 11.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ctr PF04145.15 CDI74921.1 - 6.7 7.3 4.9 8.7 6.9 4.9 1.2 1 0 0 1 1 1 0 Ctr copper transporter family CLN3 PF02487.17 CDI74921.1 - 7.5 5.5 7.1 9.4 5.2 7.1 1.1 1 0 0 1 1 1 0 CLN3 protein Ndc1_Nup PF09531.10 CDI74921.1 - 8.3 5.0 9.5 10 4.7 9.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hid1 PF12722.7 CDI74921.1 - 8.7 4.3 11.2 9.9 4.1 11.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Folate_carrier PF01770.18 CDI74921.1 - 9.6 4.8 5.7 12 4.5 5.7 1.1 1 0 0 1 1 1 0 Reduced folate carrier EOS1 PF12326.8 CDI74921.1 - 9.9 6.1 5.5 13 5.7 5.5 1.2 1 0 0 1 1 1 0 N-glycosylation protein SpoIIIAH PF12685.7 CDI74922.1 - 0.44 10.3 5.1 0.57 10.0 5.1 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein NARP1 PF12569.8 CDI74922.1 - 0.48 9.3 4.3 0.64 8.9 4.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Apt1 PF10351.9 CDI74922.1 - 1 8.1 8.6 1.2 7.9 8.6 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Coilin_N PF15862.5 CDI74922.1 - 1.2 8.9 7.3 0.89 9.4 3.9 2.1 2 0 0 2 2 2 0 Coilin N-terminus Sec62 PF03839.16 CDI74922.1 - 1.7 8.1 3.5 2.3 7.6 3.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Tim54 PF11711.8 CDI74922.1 - 2.3 6.9 6.1 3.5 6.3 6.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AAA_11 PF13086.6 CDI74923.1 - 2.3 7.9 44.2 2.9 7.6 44.2 1.1 1 0 0 1 1 1 0 AAA domain DUF572 PF04502.13 CDI74923.1 - 4.1 6.9 42.3 5.6 6.5 42.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) XPG_I PF00867.18 CDI74925.1 - 0.027 14.8 0.1 0.056 13.8 0.1 1.5 1 0 0 1 1 1 0 XPG I-region LAP1C PF05609.12 CDI74925.1 - 0.031 13.4 15.5 0.035 13.2 15.5 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) MCD PF05292.11 CDI74925.1 - 0.056 13.0 0.7 0.1 12.2 0.7 1.3 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain TFIIA PF03153.13 CDI74925.1 - 0.14 12.1 27.1 0.21 11.6 27.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SOG2 PF10428.9 CDI74925.1 - 1.8 7.7 27.3 2.3 7.3 27.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Peptidase_S64 PF08192.11 CDI74925.1 - 2 6.8 22.4 2.5 6.5 22.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 RR_TM4-6 PF06459.12 CDI74925.1 - 2.1 8.1 8.2 2.3 8.0 1.8 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Apt1 PF10351.9 CDI74926.1 - 0.0031 16.4 3.1 0.0033 16.3 3.1 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain SPX PF03105.19 CDI74926.1 - 0.0076 16.2 5.8 0.0078 16.2 5.8 1.1 1 0 0 1 1 1 1 SPX domain TFIIA PF03153.13 CDI74926.1 - 0.056 13.4 15.6 0.072 13.1 15.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1645 PF07816.11 CDI74926.1 - 0.064 13.8 9.7 0.093 13.3 9.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Spt20 PF12090.8 CDI74926.1 - 0.072 12.7 17.5 0.11 12.1 17.5 1.3 1 0 0 1 1 1 0 Spt20 family Inj_translocase PF16928.5 CDI74926.1 - 0.09 12.2 9.4 0.13 11.7 9.4 1.2 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome DUF3446 PF11928.8 CDI74926.1 - 0.095 13.0 9.7 0.27 11.5 9.7 1.8 1 0 0 1 1 1 0 Early growth response N-terminal domain Presenilin PF01080.17 CDI74926.1 - 0.13 11.0 8.4 0.19 10.5 8.4 1.2 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 CDI74926.1 - 0.19 10.2 6.9 0.25 9.9 6.9 1.0 1 0 0 1 1 1 0 Macoilin family Lin-8 PF03353.15 CDI74926.1 - 0.2 11.2 9.5 0.27 10.8 9.5 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist ST7 PF04184.12 CDI74926.1 - 0.28 9.6 0.8 0.36 9.2 0.8 1.1 1 0 0 1 1 1 0 ST7 protein MDFI PF15316.6 CDI74926.1 - 0.62 10.1 9.4 0.88 9.6 9.4 1.1 1 0 0 1 1 1 0 MyoD family inhibitor Ndc1_Nup PF09531.10 CDI74926.1 - 0.71 8.5 10.4 0.9 8.2 10.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SR-25 PF10500.9 CDI74926.1 - 0.96 9.0 19.4 1.4 8.4 19.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GREB1 PF15782.5 CDI74926.1 - 3.3 4.7 11.7 4.3 4.3 11.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer 2HCT PF03390.15 CDI74929.1 - 1.6e-05 23.8 7.0 2.4e-05 23.1 7.0 1.2 1 0 0 1 1 1 1 2-hydroxycarboxylate transporter family EMC3_TMCO1 PF01956.16 CDI74929.1 - 5.1e-05 23.1 1.7 7.5e-05 22.5 1.7 1.4 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like DDHD PF02862.17 CDI74929.1 - 0.00064 20.0 0.6 0.00064 20.0 0.6 1.1 1 0 0 1 1 1 1 DDHD domain DUF3464 PF11947.8 CDI74929.1 - 0.00087 19.1 5.5 0.00087 19.1 5.5 1.7 1 1 1 2 2 2 1 Photosynthesis affected mutant 68 Connexin PF00029.19 CDI74929.1 - 0.0027 17.5 3.2 0.0048 16.7 3.2 1.3 1 0 0 1 1 1 1 Connexin AIF_C PF14721.6 CDI74929.1 - 0.003 17.9 0.5 0.0052 17.1 0.5 1.5 1 0 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term LMBR1 PF04791.16 CDI74929.1 - 0.0036 16.3 3.4 0.0054 15.7 3.4 1.4 1 0 0 1 1 1 1 LMBR1-like membrane protein Fig1 PF12351.8 CDI74929.1 - 0.0055 16.7 8.9 0.012 15.5 8.8 1.7 1 1 0 1 1 1 1 Ca2+ regulator and membrane fusion protein Fig1 Kei1 PF08552.11 CDI74929.1 - 0.0061 16.5 3.7 0.015 15.1 3.7 1.7 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 Pex26 PF07163.12 CDI74929.1 - 0.0062 15.9 9.0 0.0095 15.3 9.0 1.3 1 0 0 1 1 1 1 Pex26 protein SUR7 PF06687.12 CDI74929.1 - 0.008 15.8 1.3 0.013 15.1 1.3 1.4 1 0 0 1 1 1 1 SUR7/PalI family Med15 PF09606.10 CDI74929.1 - 0.0091 14.7 23.4 0.012 14.4 23.4 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Scs3p PF10261.9 CDI74929.1 - 0.011 15.3 1.1 0.016 14.7 1.1 1.3 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM RR_TM4-6 PF06459.12 CDI74929.1 - 0.012 15.4 4.1 0.015 15.1 4.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LAP1C PF05609.12 CDI74929.1 - 0.015 14.4 8.5 0.02 14.0 8.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Ctr PF04145.15 CDI74929.1 - 0.016 15.9 4.5 0.016 15.9 4.5 1.7 2 0 0 2 2 1 0 Ctr copper transporter family Folliculin PF11704.8 CDI74929.1 - 0.026 14.4 5.1 0.036 14.0 5.1 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF2417 PF10329.9 CDI74929.1 - 0.031 13.7 0.1 0.064 12.7 0.1 1.6 1 0 0 1 1 1 0 Region of unknown function (DUF2417) ALMT PF11744.8 CDI74929.1 - 0.031 13.1 7.1 0.042 12.7 7.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter EIIBC-GUT_N PF03612.14 CDI74929.1 - 0.042 13.6 10.0 0.092 12.5 10.0 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus FliP PF00813.20 CDI74929.1 - 0.045 13.6 4.6 0.092 12.6 4.6 1.5 1 0 0 1 1 1 0 FliP family Calcyon PF06387.11 CDI74929.1 - 0.045 13.7 5.7 0.11 12.4 5.8 1.6 1 1 1 2 2 2 0 D1 dopamine receptor-interacting protein (calcyon) DUF3043 PF11241.8 CDI74929.1 - 0.062 13.3 12.5 0.19 11.8 12.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3043) CSG2 PF16965.5 CDI74929.1 - 0.063 12.2 2.2 0.099 11.6 2.2 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator CPSF100_C PF13299.6 CDI74929.1 - 0.11 12.7 7.4 0.17 12.1 7.4 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Suf PF05843.14 CDI74929.1 - 0.13 12.3 8.5 0.16 11.9 8.5 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Claudin_2 PF13903.6 CDI74929.1 - 0.13 12.0 12.4 0.05 13.4 9.6 1.9 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction SpoIIP PF07454.11 CDI74929.1 - 0.13 11.7 8.4 0.16 11.4 8.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) MCU PF04678.13 CDI74929.1 - 0.13 12.3 7.5 0.34 11.0 7.5 1.7 1 0 0 1 1 1 0 Mitochondrial calcium uniporter EPL1 PF10513.9 CDI74929.1 - 0.3 11.5 9.1 0.4 11.1 9.1 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like FAM60A PF15396.6 CDI74929.1 - 0.34 10.9 4.9 0.42 10.6 4.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DIE2_ALG10 PF04922.12 CDI74929.1 - 0.35 10.1 6.0 0.78 9.0 6.0 1.6 1 1 0 1 1 1 0 DIE2/ALG10 family Otopetrin PF03189.13 CDI74929.1 - 0.39 9.5 8.6 0.23 10.3 6.7 1.3 1 1 0 1 1 1 0 Otopetrin DUF1764 PF08576.10 CDI74929.1 - 0.5 11.3 7.7 0.76 10.7 7.7 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) FAM150 PF15129.6 CDI74929.1 - 0.75 10.0 7.6 1.2 9.3 7.6 1.4 1 0 0 1 1 1 0 FAM150 family TERB2 PF15101.6 CDI74929.1 - 0.94 9.5 16.5 1.5 8.9 16.5 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 UPF0524 PF15823.5 CDI74929.1 - 1.3 8.4 4.9 2 7.7 4.9 1.2 1 0 0 1 1 1 0 UPF0524 of C3orf70 Peptidase_U57 PF05582.12 CDI74929.1 - 1.3 8.2 9.5 2 7.6 9.5 1.2 1 0 0 1 1 1 0 YabG peptidase U57 eIF-3_zeta PF05091.12 CDI74929.1 - 3 6.7 15.5 3.6 6.4 15.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Band_3_cyto PF07565.13 CDI74929.1 - 3.3 7.4 10.8 4.5 7.0 10.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain EMP24_GP25L PF01105.24 CDI74929.1 - 3.7 7.5 12.4 3.2 7.6 11.2 1.6 1 1 1 2 2 1 0 emp24/gp25L/p24 family/GOLD MDM10 PF12519.8 CDI74929.1 - 5.2 5.8 8.0 6.6 5.5 8.0 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Paf1 PF03985.13 CDI74929.1 - 5.4 5.9 15.3 6.7 5.6 15.3 1.1 1 0 0 1 1 1 0 Paf1 UPF0560 PF10577.9 CDI74929.1 - 5.9 5.3 22.0 8.1 4.8 22.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 EIF4E-T PF10477.9 CDI74929.1 - 7.3 5.3 20.9 9.2 5.0 20.9 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E TMEM247 PF15444.6 CDI74929.1 - 9.7 6.2 14.5 18 5.3 14.5 1.4 1 0 0 1 1 1 0 Transmembrane protein 247 SR-25 PF10500.9 CDI74930.1 - 0.01 15.5 28.3 0.011 15.3 28.3 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SMYLE_N PF18615.1 CDI74930.1 - 1.9 8.0 27.1 2.3 7.7 27.1 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain FAM60A PF15396.6 CDI74930.1 - 2.4 8.1 30.0 3.4 7.6 30.0 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Suf PF05843.14 CDI74930.1 - 6.3 6.7 47.9 7.6 6.4 47.9 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4366 PF14283.6 CDI74932.1 - 0.0015 18.6 3.2 0.003 17.6 1.6 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4366) N6_N4_Mtase PF01555.18 CDI74932.1 - 0.061 13.0 0.0 0.13 11.9 0.0 1.6 1 1 0 1 1 1 0 DNA methylase Pol_alpha_B_N PF08418.10 CDI74932.1 - 0.082 12.9 14.4 0.11 12.4 14.4 1.3 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DUF4207 PF13904.6 CDI74932.1 - 0.14 11.8 33.6 1.2 8.8 12.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4207) Rgp1 PF08737.10 CDI74932.1 - 0.16 11.1 11.9 0.2 10.8 11.9 1.2 1 0 0 1 1 1 0 Rgp1 PA26 PF04636.13 CDI74932.1 - 0.34 9.8 8.3 0.52 9.2 8.3 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Otopetrin PF03189.13 CDI74932.1 - 0.63 8.8 3.8 0.82 8.4 3.8 1.3 1 0 0 1 1 1 0 Otopetrin DUF2828 PF11443.8 CDI74932.1 - 0.85 7.6 10.5 1.2 7.1 10.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Thg1C PF14413.6 CDI74932.1 - 0.86 9.8 11.2 0.44 10.7 1.3 2.7 3 0 0 3 3 3 0 Thg1 C terminal domain DUF966 PF06136.13 CDI74932.1 - 0.9 9.2 15.1 1.2 8.8 15.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Hid1 PF12722.7 CDI74932.1 - 1.1 7.3 15.4 1.2 7.1 15.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3474 PF11960.8 CDI74932.1 - 1.2 9.3 3.9 2.7 8.2 3.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3474) STAG PF08514.11 CDI74932.1 - 1.5 8.8 10.9 0.79 9.7 1.4 2.5 2 0 0 2 2 2 0 STAG domain DUF4175 PF13779.6 CDI74932.1 - 1.8 6.4 42.2 2 6.2 42.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Rpp20 PF12328.8 CDI74932.1 - 2 8.4 14.7 0.46 10.4 3.3 2.8 3 0 0 3 3 3 0 Rpp20 subunit of nuclear RNase MRP and P DUF45 PF01863.17 CDI74932.1 - 5.3 7.0 11.6 10 6.1 11.6 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF45 DUF3337 PF11816.8 CDI74932.1 - 6.5 6.6 10.9 0.77 9.6 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3337) ALMT PF11744.8 CDI74932.1 - 8.1 5.2 12.7 12 4.6 12.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter GREB1 PF15782.5 CDI74932.1 - 9.2 3.2 19.9 10 3.1 19.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer eIF_4EBP PF05456.11 CDI74932.1 - 9.5 6.2 19.8 0.37 10.7 7.3 2.8 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) DUF2722 PF10846.8 CDI74933.1 - 0.00065 18.8 0.6 0.00065 18.8 0.6 10.1 4 3 3 7 7 7 2 Protein of unknown function (DUF2722) MMR1 PF08505.10 CDI74933.1 - 0.0059 16.9 8.0 0.0059 16.9 8.0 6.5 4 2 2 6 6 6 1 Mitochondrial Myo2 receptor-related protein DUF1764 PF08576.10 CDI74933.1 - 0.028 15.3 0.0 0.028 15.3 0.0 7.2 4 2 1 5 5 5 0 Eukaryotic protein of unknown function (DUF1764) DUF4079 PF13301.6 CDI74933.1 - 1.9 8.6 5.0 11 6.2 0.6 4.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4079) Secretin_N_2 PF07655.13 CDI74934.1 - 0.016 15.7 9.5 0.016 15.7 9.5 3.3 3 0 0 3 3 3 0 Secretin N-terminal domain Pap_E4 PF02711.14 CDI74934.1 - 0.12 13.3 0.6 0.12 13.3 0.6 3.2 2 1 1 3 3 3 0 E4 protein SPX PF03105.19 CDI74934.1 - 0.41 10.5 20.4 0.62 9.9 20.4 1.3 1 0 0 1 1 1 0 SPX domain Myc_N PF01056.18 CDI74934.1 - 3 7.7 18.5 1.5 8.7 7.7 2.2 2 0 0 2 2 2 0 Myc amino-terminal region BPD_transp_2 PF02653.16 CDI74935.1 - 0.009 15.2 0.9 0.009 15.2 0.9 1.4 1 1 1 2 2 2 1 Branched-chain amino acid transport system / permease component CobT PF06213.12 CDI74935.1 - 0.01 15.3 29.4 0.013 14.9 29.4 1.2 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT MMU163 PF17119.5 CDI74935.1 - 0.019 14.1 9.8 0.021 14.0 9.8 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Presenilin PF01080.17 CDI74935.1 - 0.027 13.2 28.5 0.036 12.8 28.5 1.1 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 CDI74935.1 - 0.03 12.7 6.5 0.038 12.4 6.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 IHABP4_N PF16174.5 CDI74935.1 - 0.035 14.7 28.5 0.045 14.4 28.5 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal CLN3 PF02487.17 CDI74935.1 - 0.043 12.9 14.2 0.052 12.6 14.2 1.1 1 0 0 1 1 1 0 CLN3 protein DUF2828 PF11443.8 CDI74935.1 - 0.062 11.4 16.2 0.064 11.3 16.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Velvet PF11754.8 CDI74935.1 - 0.067 13.1 20.0 0.077 12.9 20.0 1.2 1 0 0 1 1 1 0 Velvet factor DUF913 PF06025.12 CDI74935.1 - 0.078 11.9 11.7 0.088 11.8 11.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 CDI74935.1 - 0.092 12.6 21.4 0.11 12.4 21.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF572 PF04502.13 CDI74935.1 - 0.11 12.1 18.4 0.12 12.0 18.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Mem_trans PF03547.18 CDI74935.1 - 0.12 10.7 8.0 0.15 10.5 8.0 1.2 1 0 0 1 1 1 0 Membrane transport protein CCSAP PF15748.5 CDI74935.1 - 0.13 12.5 24.0 0.13 12.4 24.0 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF2464 PF10240.9 CDI74935.1 - 0.15 11.7 12.2 0.17 11.4 12.2 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 Dapper PF15268.6 CDI74935.1 - 0.21 10.4 28.8 0.22 10.3 28.8 1.1 1 0 0 1 1 1 0 Dapper V_ATPase_I PF01496.19 CDI74935.1 - 0.21 9.5 23.9 0.25 9.2 23.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RIFIN PF02009.16 CDI74935.1 - 0.22 11.4 19.6 0.25 11.2 19.6 1.0 1 0 0 1 1 1 0 Rifin GAGA_bind PF06217.12 CDI74935.1 - 0.24 11.6 18.8 0.27 11.5 18.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family O-antigen_lig PF13425.6 CDI74935.1 - 0.25 10.1 5.9 0.27 10.0 5.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PA26 PF04636.13 CDI74935.1 - 0.26 10.2 14.6 0.27 10.1 14.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SARAF PF06682.12 CDI74935.1 - 0.26 10.9 19.1 0.31 10.7 19.1 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Endostatin PF06482.11 CDI74935.1 - 0.28 10.6 21.1 0.31 10.5 21.1 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Bul1_N PF04425.12 CDI74935.1 - 0.29 9.9 19.5 0.33 9.6 19.5 1.0 1 0 0 1 1 1 0 Bul1 N terminus AMP-binding PF00501.28 CDI74935.1 - 0.31 9.6 10.5 0.39 9.3 10.5 1.0 1 0 0 1 1 1 0 AMP-binding enzyme ALMT PF11744.8 CDI74935.1 - 0.36 9.6 17.7 0.4 9.5 17.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF1387 PF07139.11 CDI74935.1 - 0.36 10.5 20.7 0.47 10.2 20.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) FAM60A PF15396.6 CDI74935.1 - 0.43 10.5 15.3 0.5 10.3 15.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF3295 PF11702.8 CDI74935.1 - 0.44 9.9 22.1 0.53 9.6 22.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) HCO3_cotransp PF00955.21 CDI74935.1 - 0.44 9.3 7.1 0.48 9.2 7.1 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF4746 PF15928.5 CDI74935.1 - 0.44 9.9 12.8 0.59 9.5 12.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF2052 PF09747.9 CDI74935.1 - 0.45 10.6 21.3 0.52 10.4 21.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Tmp39 PF10271.9 CDI74935.1 - 0.56 9.1 4.4 0.6 9.1 4.4 1.1 1 0 0 1 1 1 0 Putative transmembrane protein PAT1 PF09770.9 CDI74935.1 - 0.59 8.3 47.6 0.66 8.2 47.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Paramyxo_ncap PF00973.19 CDI74935.1 - 0.63 8.9 19.6 0.74 8.7 19.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein SART-1 PF03343.13 CDI74935.1 - 0.7 8.4 27.0 0.77 8.2 27.0 1.1 1 0 0 1 1 1 0 SART-1 family SLC12 PF03522.15 CDI74935.1 - 0.7 8.8 24.1 0.8 8.7 24.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 MRP-S26 PF14943.6 CDI74935.1 - 0.71 9.8 22.2 0.91 9.4 22.2 1.1 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Gti1_Pac2 PF09729.9 CDI74935.1 - 0.71 9.9 16.6 0.99 9.5 16.6 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF2126 PF09899.9 CDI74935.1 - 1.2 7.1 14.2 1.3 7.0 14.2 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CSG2 PF16965.5 CDI74935.1 - 1.2 8.0 11.8 1.5 7.7 11.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator AUX_IAA PF02309.16 CDI74935.1 - 1.2 8.9 13.8 1.5 8.6 13.8 1.3 1 0 0 1 1 1 0 AUX/IAA family CBP_BcsG PF11658.8 CDI74935.1 - 1.5 7.2 20.4 1.9 6.8 20.4 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Ribosomal_60s PF00428.19 CDI74935.1 - 1.5 9.5 14.3 3.9 8.1 14.3 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein BORG_CEP PF14957.6 CDI74935.1 - 2 9.6 16.6 2.4 9.3 16.6 1.2 1 0 0 1 1 1 0 Cdc42 effector Hid1 PF12722.7 CDI74935.1 - 2 6.5 21.1 2 6.4 21.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PPL5 PF18168.1 CDI74935.1 - 2.1 7.6 12.3 3.2 7.0 12.3 1.4 1 0 0 1 1 1 0 Prim-pol family 5 Med19 PF10278.9 CDI74935.1 - 2.7 7.9 12.5 3.5 7.5 12.5 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Hydin_ADK PF17213.3 CDI74935.1 - 2.9 8.1 23.3 4.4 7.6 23.3 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain PTPRCAP PF15713.5 CDI74935.1 - 3.1 8.1 24.4 5.4 7.3 24.4 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF3807 PF12720.7 CDI74935.1 - 3.8 7.7 32.6 5.4 7.2 32.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) SWI-SNF_Ssr4 PF08549.10 CDI74935.1 - 4.9 5.7 29.3 5.8 5.4 29.3 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) XRN_M PF17846.1 CDI74935.1 - 5.5 5.8 16.7 6 5.7 16.7 1.1 1 0 0 1 1 1 0 Xrn1 helical domain DUF2079 PF09852.9 CDI74935.1 - 7.4 5.3 14.0 8.9 5.0 14.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) DREPP PF05558.12 CDI74935.1 - 8.9 6.1 13.1 4.5 7.1 10.3 1.7 1 1 1 2 2 2 0 DREPP plasma membrane polypeptide Exonuc_VII_L PF02601.15 CDI74935.1 - 9.6 5.7 30.4 9.9 5.6 30.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2722 PF10846.8 CDI74936.1 - 0.0003 19.9 45.5 0.0027 16.7 18.4 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) Presenilin PF01080.17 CDI74936.1 - 0.00038 19.3 20.5 0.00046 19.1 20.5 1.1 1 0 0 1 1 1 1 Presenilin DUF4484 PF14831.6 CDI74936.1 - 0.026 14.6 14.9 0.037 14.1 14.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) PAXIP1_C PF15364.6 CDI74936.1 - 0.028 14.7 14.3 0.15 12.4 3.0 2.1 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein SLD3 PF08639.10 CDI74936.1 - 0.046 12.5 19.2 0.057 12.2 19.2 1.0 1 0 0 1 1 1 0 DNA replication regulator SLD3 SLC12 PF03522.15 CDI74936.1 - 0.072 12.1 21.1 0.089 11.8 21.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 EPL1 PF10513.9 CDI74936.1 - 0.073 13.4 23.0 0.39 11.1 6.6 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like Rgp1 PF08737.10 CDI74936.1 - 0.096 11.8 15.5 0.13 11.5 15.5 1.2 1 0 0 1 1 1 0 Rgp1 DUF4628 PF15429.6 CDI74936.1 - 0.1 12.3 17.8 0.18 11.4 4.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4628) ALMT PF11744.8 CDI74936.1 - 0.11 11.3 15.6 0.15 10.9 15.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Ribosomal_60s PF00428.19 CDI74936.1 - 0.11 13.1 22.7 0.18 12.4 0.8 3.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF702 PF05142.12 CDI74936.1 - 0.2 12.2 22.8 0.096 13.2 5.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF702) DUF3464 PF11947.8 CDI74936.1 - 0.3 10.8 22.2 0.74 9.6 6.9 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 CDC27 PF09507.10 CDI74936.1 - 0.35 10.2 22.2 0.43 9.9 22.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Peptidase_M56 PF05569.11 CDI74936.1 - 0.39 9.8 6.3 0.53 9.4 6.3 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 Ndc1_Nup PF09531.10 CDI74936.1 - 0.41 9.3 22.5 0.47 9.1 22.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3347 PF11827.8 CDI74936.1 - 0.52 10.5 24.3 0.8 9.9 10.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) Mak16 PF04874.14 CDI74936.1 - 0.54 10.9 22.2 0.2 12.3 4.8 2.3 2 0 0 2 2 2 0 Mak16 protein C-terminal region DUF3381 PF11861.8 CDI74936.1 - 0.6 9.9 31.5 1.3 8.8 13.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) CFIA_Pcf11 PF11526.8 CDI74936.1 - 0.73 10.4 23.7 0.68 10.5 7.1 2.2 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 TERB2 PF15101.6 CDI74936.1 - 0.85 9.6 34.2 0.98 9.4 11.0 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 HABP4_PAI-RBP1 PF04774.15 CDI74936.1 - 1.4 9.8 23.6 2.8 8.8 4.5 2.2 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family CRT10 PF08728.10 CDI74936.1 - 1.4 7.0 9.1 1.6 6.8 9.1 1.0 1 0 0 1 1 1 0 CRT10 MDM10 PF12519.8 CDI74936.1 - 1.6 7.5 18.6 2.2 7.1 18.6 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Porph_ging PF09697.10 CDI74936.1 - 1.6 9.3 14.5 4.4 7.9 3.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) DUF966 PF06136.13 CDI74936.1 - 1.8 8.2 17.6 2.2 7.9 17.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Sin_N PF04801.13 CDI74936.1 - 2.1 7.5 35.6 3.2 6.9 35.6 1.3 1 0 0 1 1 1 0 Sin-like protein conserved region Hid1 PF12722.7 CDI74936.1 - 2.1 6.4 25.8 2.6 6.1 25.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Spore_III_AF PF09581.10 CDI74936.1 - 2.2 8.3 22.1 0.54 10.3 6.9 2.2 2 0 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) Prothymosin PF03247.14 CDI74936.1 - 2.3 8.7 23.0 3.8 8.0 9.9 2.1 2 0 0 2 2 2 0 Prothymosin/parathymosin family XRN_M PF17846.1 CDI74936.1 - 3.2 6.6 16.7 4 6.3 16.7 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Mlh1_C PF16413.5 CDI74936.1 - 3.4 7.0 20.4 4.1 6.7 6.5 2.1 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus GD_AH_C PF04295.13 CDI74936.1 - 3.8 6.2 11.3 4.8 5.9 11.3 1.2 1 0 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus YhfC PF10086.9 CDI74936.1 - 4.1 6.7 14.1 5.5 6.3 3.3 2.2 2 0 0 2 2 2 0 YhfC intramembrane metalloprotease PBP1_TM PF14812.6 CDI74936.1 - 4.1 7.8 11.3 6.9 7.1 3.7 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Tmemb_9 PF05434.11 CDI74936.1 - 4.1 7.3 15.5 0.88 9.5 3.7 2.2 2 0 0 2 2 2 0 TMEM9 AIM3 PF17096.5 CDI74936.1 - 4.3 8.3 18.8 10 7.1 3.7 2.4 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 DcuA_DcuB PF03605.14 CDI74936.1 - 4.3 6.1 12.5 0.34 9.8 1.0 2.1 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter HA2 PF04408.23 CDI74936.1 - 4.4 7.6 18.2 2 8.7 5.7 2.3 2 0 0 2 2 2 0 Helicase associated domain (HA2) Bud13 PF09736.9 CDI74936.1 - 4.4 7.7 36.5 4.3 7.7 10.0 2.1 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex PRP1_N PF06424.12 CDI74936.1 - 6.6 7.1 23.1 8.9 6.7 6.5 2.2 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal TraV PF09676.10 CDI74936.1 - 6.9 7.7 25.9 7.5 7.5 12.9 2.2 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) DUF4064 PF13273.6 CDI74936.1 - 7.2 6.9 11.9 5.3 7.4 2.9 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) NPR3 PF03666.13 CDI74936.1 - 7.4 5.2 20.3 1.6 7.5 2.9 2.0 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Paf1 PF03985.13 CDI74936.1 - 8.2 5.3 30.7 5.3 5.9 8.9 2.1 2 0 0 2 2 2 0 Paf1 Fungal_trans_2 PF11951.8 CDI74936.1 - 8.7 5.0 12.6 0.36 9.6 5.5 1.8 1 1 1 2 2 2 0 Fungal specific transcription factor domain PEX11 PF05648.14 CDI74936.1 - 9.3 5.6 23.1 5.8 6.3 7.9 2.1 1 1 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) Sox_N PF12444.8 CDI74936.1 - 9.5 7.4 13.4 15 6.8 1.6 2.3 2 0 0 2 2 2 0 Sox developmental protein N terminal ARF7EP_C PF14949.6 CDI74936.1 - 9.7 6.9 17.2 12 6.5 4.8 2.2 2 0 0 2 2 2 0 ARF7 effector protein C-terminus WRNPLPNID PF15017.6 CDI74936.1 - 9.9 7.1 21.8 3 8.8 5.8 2.4 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box E1-E2_ATPase PF00122.20 CDI74937.1 - 1.3e-08 34.6 0.0 5.7e-08 32.5 0.0 2.2 1 1 0 1 1 1 1 E1-E2 ATPase RskA PF10099.9 CDI74937.1 - 1.7e-05 25.2 7.1 1.7e-05 25.2 7.1 14.5 7 3 4 11 11 11 3 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI74937.1 - 0.00017 21.3 11.3 0.00017 21.3 11.3 9.0 6 4 1 7 7 7 2 Spt20 family SR-25 PF10500.9 CDI74937.1 - 0.0018 17.9 11.8 0.0018 17.9 11.8 7.9 7 1 2 9 9 9 1 Nuclear RNA-splicing-associated protein SARAF PF06682.12 CDI74938.1 - 0.00044 20.0 21.8 0.00044 20.0 21.8 1.8 2 0 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis Lin-8 PF03353.15 CDI74938.1 - 0.00069 19.3 20.8 0.00069 19.3 20.8 2.3 2 0 0 2 2 2 1 Ras-mediated vulval-induction antagonist Pex14_N PF04695.13 CDI74938.1 - 0.0014 19.3 29.7 0.0014 19.3 29.7 4.4 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region SID-1_RNA_chan PF13965.6 CDI74938.1 - 0.13 10.7 12.3 0.19 10.1 12.3 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Cellulose_synt PF03552.14 CDI74938.1 - 0.35 9.3 7.6 0.7 8.3 7.6 1.5 1 0 0 1 1 1 0 Cellulose synthase Utp14 PF04615.13 CDI74938.1 - 0.67 8.5 31.9 1 7.9 31.9 1.2 1 0 0 1 1 1 0 Utp14 protein PBP1_TM PF14812.6 CDI74938.1 - 3 8.3 8.5 9.1 6.7 8.5 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Vfa1 PF08432.10 CDI74938.1 - 3.4 7.9 36.9 2.4 8.4 24.5 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF2126 PF09899.9 CDI74938.1 - 8.1 4.4 20.4 12 3.8 20.4 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) KH_1 PF00013.29 CDI74939.1 - 1e-21 76.5 2.2 7e-07 29.0 0.0 6.5 7 0 0 7 7 7 5 KH domain BMC PF00936.19 CDI74939.1 - 0.059 13.4 2.1 1.9 8.5 0.0 4.1 5 0 0 5 5 5 0 BMC domain KH_2 PF07650.17 CDI74939.1 - 0.11 12.4 10.4 1.7 8.5 0.0 4.3 4 1 1 5 5 5 0 KH domain CTP_transf_like PF01467.26 CDI74940.1 - 3.3e-31 108.4 0.2 1.2e-30 106.5 0.2 2.1 1 0 0 1 1 1 1 Cytidylyltransferase-like ATG16 PF08614.11 CDI74940.1 - 0.00026 21.3 34.5 0.46 10.7 9.9 3.8 3 0 0 3 3 3 3 Autophagy protein 16 (ATG16) DUF4424 PF14415.6 CDI74940.1 - 0.49 9.6 4.0 1.3 8.2 4.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4424) Syntaxin_2 PF14523.6 CDI74940.1 - 2 8.8 14.0 2.5 8.5 2.8 4.0 4 0 0 4 4 4 0 Syntaxin-like protein UPF0242 PF06785.11 CDI74940.1 - 2.1 8.4 28.5 0.14 12.2 2.5 3.4 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Filament PF00038.21 CDI74940.1 - 4.2 6.9 30.1 1.2 8.6 11.5 3.4 3 0 0 3 3 3 0 Intermediate filament protein GAS PF13851.6 CDI74940.1 - 8.8 5.6 38.5 0.81 9.0 9.5 3.1 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Pribosyltran PF00156.27 CDI74941.1 - 2e-22 79.4 0.0 2.5e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Phage_endo_I PF05367.11 CDI74941.1 - 0.049 13.2 0.0 0.078 12.6 0.0 1.3 1 0 0 1 1 1 0 Phage endonuclease I RskA PF10099.9 CDI74942.1 - 2.6e-06 27.8 4.7 2.6e-06 27.8 4.7 3.5 1 1 2 3 3 3 1 Anti-sigma-K factor rskA Spem1 PF15670.5 CDI74942.1 - 1.3 8.6 14.4 2.2 7.8 14.4 1.3 1 0 0 1 1 1 0 Spermatid maturation protein 1 Cellulose_synt PF03552.14 CDI74942.1 - 5.4 5.4 6.0 7.3 4.9 6.0 1.1 1 0 0 1 1 1 0 Cellulose synthase RskA PF10099.9 CDI74943.1 - 0.0063 16.8 14.9 0.0063 16.8 14.9 13.8 3 3 5 8 8 8 1 Anti-sigma-K factor rskA PBP1_TM PF14812.6 CDI74945.1 - 0.0021 18.4 1.0 0.0021 18.4 1.0 4.0 3 0 0 3 3 3 1 Transmembrane domain of transglycosylase PBP1 at N-terminal GET2 PF08690.10 CDI74945.1 - 0.0024 17.6 3.1 0.0024 17.6 3.1 8.3 2 1 1 7 7 7 1 GET complex subunit GET2 NST1 PF13945.6 CDI74945.1 - 0.0051 16.9 1.7 0.0051 16.9 1.7 7.9 5 3 2 7 7 7 1 Salt tolerance down-regulator Orf78 PF06024.12 CDI74945.1 - 0.0055 17.0 0.9 0.0055 17.0 0.9 8.2 9 1 0 9 9 9 1 Orf78 (ac78) MMR1 PF08505.10 CDI74945.1 - 0.0079 16.5 2.5 0.0079 16.5 2.5 7.1 2 1 3 7 7 7 1 Mitochondrial Myo2 receptor-related protein DUF2207 PF09972.9 CDI74945.1 - 0.064 12.0 0.1 0.064 12.0 0.1 2.8 4 0 0 4 4 4 0 Predicted membrane protein (DUF2207) BatA PF07584.11 CDI74945.1 - 0.14 12.5 3.6 1.6 9.2 3.6 3.0 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal Pkinase PF00069.25 CDI74946.1 - 1.5e-30 106.5 0.0 2.2e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI74946.1 - 3.5e-12 46.2 0.0 9.4e-12 44.8 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase EF-hand_6 PF13405.6 CDI74946.1 - 6.3e-11 41.3 0.4 0.0015 18.3 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 CDI74946.1 - 3.6e-10 40.1 0.2 8e-05 23.0 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDI74946.1 - 7.7e-10 37.6 1.1 0.001 18.4 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 CDI74946.1 - 2.8e-07 29.7 5.6 0.003 17.0 0.5 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 CDI74946.1 - 5.3e-06 26.2 0.1 0.058 13.3 0.0 3.4 3 0 0 3 3 3 1 EF-hand domain pair Kinase-like PF14531.6 CDI74946.1 - 1.3e-05 24.7 0.0 4.5e-05 22.9 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Dockerin_1 PF00404.18 CDI74946.1 - 0.053 13.7 0.8 0.6 10.3 0.4 2.3 1 1 1 2 2 2 0 Dockerin type I domain EF-hand_4 PF12763.7 CDI74946.1 - 0.2 11.6 1.2 1.7 8.7 0.1 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Spt20 PF12090.8 CDI74947.1 - 1.7e-05 24.6 13.0 1.7e-05 24.6 13.0 1.1 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 CDI74947.1 - 0.0031 17.6 11.0 0.0031 17.6 11.0 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit OrgA_MxiK PF09482.10 CDI74947.1 - 0.0059 16.5 0.2 0.0072 16.2 0.2 1.1 1 0 0 1 1 1 1 Bacterial type III secretion apparatus protein (OrgA_MxiK) DUF4834 PF16118.5 CDI74947.1 - 0.0063 17.5 5.6 0.0073 17.2 5.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Med15 PF09606.10 CDI74947.1 - 0.012 14.4 11.8 0.011 14.4 11.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CLN3 PF02487.17 CDI74947.1 - 0.035 13.2 1.0 0.038 13.1 1.0 1.0 1 0 0 1 1 1 0 CLN3 protein FAM91_C PF14648.6 CDI74947.1 - 0.054 12.3 1.8 0.054 12.3 1.8 1.0 1 0 0 1 1 1 0 FAM91 C-terminus GRP PF07172.11 CDI74947.1 - 0.058 14.1 0.2 0.078 13.7 0.2 1.2 1 0 0 1 1 1 0 Glycine rich protein family Presenilin PF01080.17 CDI74947.1 - 0.066 12.0 3.5 0.062 12.1 3.5 1.0 1 0 0 1 1 1 0 Presenilin DivIC PF04977.15 CDI74947.1 - 0.067 13.0 11.3 0.086 12.6 11.3 1.2 1 0 0 1 1 1 0 Septum formation initiator Connexin PF00029.19 CDI74947.1 - 0.1 12.4 2.8 0.11 12.2 2.8 1.1 1 0 0 1 1 1 0 Connexin TMEM51 PF15345.6 CDI74947.1 - 0.1 12.4 6.4 0.12 12.2 6.4 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 eIF-3_zeta PF05091.12 CDI74947.1 - 0.1 11.5 8.5 0.092 11.7 8.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RPA43_OB PF17875.1 CDI74947.1 - 0.11 13.1 4.8 0.13 12.9 4.8 1.1 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I FHIPEP PF00771.20 CDI74947.1 - 0.11 11.0 1.6 0.11 10.9 1.6 1.0 1 0 0 1 1 1 0 FHIPEP family Folate_carrier PF01770.18 CDI74947.1 - 0.11 11.2 2.8 0.13 10.9 2.8 1.0 1 0 0 1 1 1 0 Reduced folate carrier TMEM220 PF15071.6 CDI74947.1 - 0.13 13.1 0.0 0.16 12.8 0.0 1.1 1 0 0 1 1 1 0 Transmembrane family 220, helix TMEM208_SND2 PF05620.11 CDI74947.1 - 0.19 11.5 6.8 0.24 11.2 6.8 1.2 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 OATP PF03137.20 CDI74947.1 - 0.22 9.8 1.6 0.22 9.8 1.6 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4175 PF13779.6 CDI74947.1 - 0.23 9.3 14.1 0.22 9.4 14.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) EIIBC-GUT_N PF03612.14 CDI74947.1 - 0.24 11.1 4.4 0.27 11.0 4.4 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Serinc PF03348.15 CDI74947.1 - 0.27 10.1 1.6 0.26 10.2 1.6 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) EphA2_TM PF14575.6 CDI74947.1 - 0.27 12.2 1.8 0.36 11.7 1.8 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Conotoxin PF02950.17 CDI74947.1 - 0.29 12.2 4.2 0.11 13.5 1.9 1.6 2 0 0 2 2 1 0 Conotoxin DUF3464 PF11947.8 CDI74947.1 - 0.37 10.5 5.8 0.4 10.4 5.8 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 UPF0560 PF10577.9 CDI74947.1 - 0.63 8.5 9.4 0.67 8.4 9.4 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF2722 PF10846.8 CDI74947.1 - 0.96 8.3 22.0 1.2 8.0 22.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) RED_N PF07808.13 CDI74947.1 - 1.1 8.7 12.6 1.3 8.6 12.6 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF2967 PF11179.8 CDI74947.1 - 1.6 6.7 10.2 1.7 6.6 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) SelK_SelG PF10961.8 CDI74947.1 - 2.1 9.0 5.9 6.8 7.4 5.9 1.7 1 1 0 1 1 1 0 Selenoprotein SelK_SelG Med3 PF11593.8 CDI74947.1 - 8.8 5.4 17.3 11 5.1 17.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Coilin_N PF15862.5 CDI74948.1 - 0.00031 20.5 5.1 0.00031 20.5 5.1 4.3 2 1 2 4 4 4 2 Coilin N-terminus RAP1 PF07218.11 CDI74948.1 - 4.2 5.5 24.4 6.7 4.9 24.4 1.4 1 1 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Conotoxin PF02950.17 CDI74949.1 - 0.00033 21.6 13.6 0.078 14.0 0.6 2.1 2 0 0 2 2 2 2 Conotoxin DUF2828 PF11443.8 CDI74949.1 - 0.0015 16.8 13.5 0.0015 16.7 13.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) V_ATPase_I PF01496.19 CDI74949.1 - 0.0072 14.3 14.8 0.0078 14.2 14.8 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI74949.1 - 0.022 13.8 11.9 0.025 13.6 11.9 1.1 1 0 0 1 1 1 0 CLN3 protein Tim54 PF11711.8 CDI74949.1 - 0.096 11.4 12.5 0.11 11.2 12.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF1117 PF06547.12 CDI74949.1 - 0.1 13.1 0.6 0.13 12.8 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1117) DUF4336 PF14234.6 CDI74949.1 - 0.1 11.7 8.0 0.12 11.5 8.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4336) Kei1 PF08552.11 CDI74949.1 - 0.19 11.6 11.7 0.22 11.4 11.7 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Serinc PF03348.15 CDI74949.1 - 0.22 10.4 9.0 0.25 10.2 9.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) PIP5K PF01504.18 CDI74949.1 - 0.29 10.3 14.4 0.35 10.1 14.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Rgp1 PF08737.10 CDI74949.1 - 0.49 9.5 13.7 0.51 9.5 13.7 1.0 1 0 0 1 1 1 0 Rgp1 Folliculin PF11704.8 CDI74949.1 - 0.78 9.6 12.8 1 9.3 12.8 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Presenilin PF01080.17 CDI74949.1 - 1.1 8.0 22.3 1.2 7.8 22.3 1.1 1 0 0 1 1 1 0 Presenilin TMEM220 PF15071.6 CDI74949.1 - 1.7 9.4 3.2 25 5.7 0.6 2.0 1 1 1 2 2 2 0 Transmembrane family 220, helix ALMT PF11744.8 CDI74949.1 - 1.7 7.4 14.5 1.9 7.2 14.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter YABBY PF04690.13 CDI74949.1 - 1.8 9.1 14.2 2.6 8.6 14.2 1.2 1 0 0 1 1 1 0 YABBY protein Peptidase_U57 PF05582.12 CDI74949.1 - 1.9 7.7 10.9 2.4 7.3 10.9 1.1 1 0 0 1 1 1 0 YabG peptidase U57 GRP PF07172.11 CDI74949.1 - 2.4 8.9 10.9 2 9.2 1.0 2.1 1 1 1 2 2 2 0 Glycine rich protein family Sec62 PF03839.16 CDI74949.1 - 2.4 7.6 14.8 3.1 7.2 14.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 BORG_CEP PF14957.6 CDI74949.1 - 2.4 9.3 11.1 3.3 8.9 11.1 1.3 1 0 0 1 1 1 0 Cdc42 effector DUF4050 PF13259.6 CDI74949.1 - 2.8 8.2 15.3 3.2 8.0 15.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) PAT1 PF09770.9 CDI74949.1 - 3.2 5.9 31.6 3.7 5.7 31.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CSG2 PF16965.5 CDI74949.1 - 3.5 6.5 8.5 4.9 6.0 8.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator SLC12 PF03522.15 CDI74949.1 - 3.7 6.5 18.4 4.2 6.3 18.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI74949.1 - 3.8 7.5 13.5 5.1 7.1 13.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region eIF_4EBP PF05456.11 CDI74949.1 - 4.2 7.4 17.0 0.42 10.6 0.8 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) DUF2126 PF09899.9 CDI74949.1 - 4.3 5.3 12.8 4.9 5.1 12.8 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) RR_TM4-6 PF06459.12 CDI74949.1 - 4.9 6.9 20.4 6.1 6.6 20.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Gti1_Pac2 PF09729.9 CDI74949.1 - 7.5 6.6 16.3 9.6 6.3 16.3 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Ndc1_Nup PF09531.10 CDI74949.1 - 8.1 5.0 14.8 9.4 4.8 14.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3742 PF12553.8 CDI74949.1 - 8.3 6.6 7.7 1.1 9.4 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3742) FAM60A PF15396.6 CDI74949.1 - 8.6 6.3 14.0 12 5.9 14.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF2722 PF10846.8 CDI74951.1 - 0.0013 17.8 8.0 0.0034 16.4 1.7 4.5 4 1 0 4 4 4 2 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI74951.1 - 0.0025 17.9 6.1 0.0025 17.9 6.1 3.3 3 1 0 3 3 3 2 Transcription factor IIA, alpha/beta subunit Methyltransf_23 PF13489.6 CDI74951.1 - 0.95 9.3 4.0 14 5.5 0.1 3.1 3 0 0 3 3 3 0 Methyltransferase domain Spt20 PF12090.8 CDI74951.1 - 1.5 8.4 72.7 0.027 14.1 2.1 4.3 4 1 0 4 4 4 0 Spt20 family CIAPIN1 PF05093.13 CDI74951.1 - 9.1 6.9 9.9 67 4.1 0.2 3.9 3 0 0 3 3 3 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis RED_N PF07808.13 CDI74954.1 - 0.0093 15.6 3.7 0.0093 15.6 3.7 4.4 2 1 1 4 4 4 1 RED-like protein N-terminal region DUF2339 PF10101.9 CDI74955.1 - 0.027 13.1 11.7 0.035 12.7 11.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) FHIPEP PF00771.20 CDI74955.1 - 1.5 7.2 11.6 2.2 6.7 11.6 1.2 1 0 0 1 1 1 0 FHIPEP family TAF4 PF05236.14 CDI74955.1 - 3.7 7.2 35.2 6.4 6.4 5.7 2.7 1 1 1 2 2 2 0 Transcription initiation factor TFIID component TAF4 family SPT16 PF08644.11 CDI74955.1 - 6.8 6.9 11.6 13 5.9 4.9 2.3 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) BUD22 PF09073.10 CDI74957.1 - 2e-06 27.5 14.3 2e-06 27.5 14.3 4.5 3 1 2 5 5 3 2 BUD22 SUIM_assoc PF16619.5 CDI74957.1 - 0.00047 20.2 1.8 0.00047 20.2 1.8 8.3 5 2 2 7 7 2 2 Unstructured region C-term to UIM in Ataxin3 AAA_18 PF13238.6 CDI74957.1 - 0.00054 20.5 0.2 0.00054 20.5 0.2 3.6 4 1 0 4 4 3 1 AAA domain cobW PF02492.19 CDI74957.1 - 0.0014 18.3 0.0 0.0048 16.5 0.0 2.0 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 CDI74957.1 - 0.0014 18.3 0.0 0.0035 17.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Spt20 PF12090.8 CDI74957.1 - 0.0026 17.4 11.8 0.0026 17.4 11.8 6.8 4 1 0 4 4 3 2 Spt20 family T2SSE PF00437.20 CDI74957.1 - 0.0028 16.7 0.5 0.0078 15.3 0.0 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.6 CDI74957.1 - 0.0037 17.5 0.4 0.014 15.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain Plasmodium_Vir PF05795.11 CDI74957.1 - 0.0038 16.7 1.4 0.0038 16.7 1.4 4.6 4 1 0 4 4 3 1 Plasmodium vivax Vir protein AAA PF00004.29 CDI74957.1 - 0.011 16.2 0.0 0.047 14.1 0.0 2.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) YqfQ PF14181.6 CDI74957.1 - 0.014 15.7 0.5 0.014 15.7 0.5 8.3 8 2 1 9 9 6 0 YqfQ-like protein ABC_membrane PF00664.23 CDI74957.1 - 0.026 14.2 0.2 0.026 14.2 0.2 1.7 2 0 0 2 2 2 0 ABC transporter transmembrane region AAA_33 PF13671.6 CDI74957.1 - 0.084 13.0 0.0 0.084 13.0 0.0 4.1 4 0 0 4 4 3 0 AAA domain AAA_24 PF13479.6 CDI74957.1 - 0.24 11.1 0.0 0.24 11.1 0.0 4.5 5 1 0 5 5 4 0 AAA domain Integrase_H2C2 PF17921.1 CDI74958.1 - 2e-22 79.0 3.7 6.3e-13 48.6 0.3 2.9 2 1 1 3 3 3 2 Integrase zinc binding domain RT_RNaseH PF17917.1 CDI74958.1 - 9.9e-17 61.1 0.5 4.2e-16 59.1 0.2 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDI74958.1 - 8.6e-16 58.2 1.2 1.5e-13 51.0 0.0 4.1 5 0 0 5 5 5 1 Integrase core domain RT_RNaseH_2 PF17919.1 CDI74958.1 - 1.1e-05 25.4 0.0 6.1e-05 23.0 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 CDI74958.1 - 7e-05 22.5 1.0 11 5.9 0.0 4.6 3 1 1 4 4 4 2 Integrase core domain zf-H2C2 PF09337.10 CDI74958.1 - 0.00043 20.4 0.0 1.2 9.5 0.0 2.6 2 0 0 2 2 2 2 H2C2 zinc finger DUF3742 PF12553.8 CDI74958.1 - 0.028 14.5 0.5 2.6 8.2 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3742) Chromadorea_ALT PF05535.12 CDI74958.1 - 0.14 12.4 0.1 17 5.7 0.0 2.4 1 1 1 2 2 2 0 Chromadorea ALT protein DUF4558 PF15104.6 CDI74958.1 - 6.9 6.8 6.5 53 4.0 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4558) Chromo PF00385.24 CDI74959.1 - 3.2e-09 36.6 0.0 4.9e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Gpi1 PF05024.15 CDI74960.1 - 3e-09 37.2 3.0 3.3e-09 37.1 0.2 2.2 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) DUF3208 PF11482.8 CDI74961.1 - 0.0052 17.1 0.1 0.011 16.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3208) DEAD PF00270.29 CDI74964.1 - 4.1e-07 29.9 0.0 7.2e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 CDI74964.1 - 0.012 15.3 1.3 0.027 14.2 1.3 1.6 1 0 0 1 1 1 0 AAA domain SseC PF04888.12 CDI74965.1 - 0.0062 16.2 12.5 0.0062 16.2 12.5 7.3 6 1 0 6 6 6 1 Secretion system effector C (SseC) like family FTZ PF03867.14 CDI74966.1 - 3 7.3 14.4 4.6 6.7 14.4 1.3 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region TRM13 PF05206.14 CDI74967.1 - 0.021 14.3 10.8 0.023 14.3 10.8 1.0 1 0 0 1 1 1 0 Methyltransferase TRM13 Glyco_transf_8 PF01501.20 CDI74967.1 - 0.45 10.0 6.1 0.55 9.7 6.1 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 8 SMYLE_N PF18615.1 CDI74967.1 - 0.89 9.0 17.9 0.97 8.9 17.9 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Activator_LAG-3 PF11498.8 CDI74967.1 - 1.1 8.2 59.8 1.3 7.9 59.8 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 eIF-3_zeta PF05091.12 CDI74967.1 - 1.6 7.7 23.9 1.6 7.6 23.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Baculo_PP31 PF05311.11 CDI74967.1 - 2.1 7.7 18.2 2.3 7.7 18.2 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) O-antigen_lig PF13425.6 CDI74967.1 - 2.5 6.8 9.7 2.7 6.7 9.7 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CDC45 PF02724.14 CDI74967.1 - 2.6 6.2 17.0 2.9 6.1 17.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 CDI74967.1 - 2.7 7.7 12.8 3 7.5 12.8 1.3 1 0 0 1 1 1 0 Connexin Peptidase_S49_N PF08496.10 CDI74967.1 - 2.9 7.9 17.7 4.1 7.4 17.7 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Band_3_cyto PF07565.13 CDI74967.1 - 3.5 7.3 18.5 3.9 7.2 18.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Velvet PF11754.8 CDI74967.1 - 3.6 7.4 19.0 3.8 7.4 19.0 1.1 1 0 0 1 1 1 0 Velvet factor RR_TM4-6 PF06459.12 CDI74967.1 - 4.4 7.1 23.2 4.6 7.0 23.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 V_ATPase_I PF01496.19 CDI74967.1 - 4.5 5.1 20.7 4.6 5.0 20.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EOS1 PF12326.8 CDI74967.1 - 4.5 7.2 11.3 5.9 6.8 11.3 1.3 1 0 0 1 1 1 0 N-glycosylation protein 2OG-FeII_Oxy_5 PF13759.6 CDI74967.1 - 4.6 7.7 10.9 6.5 7.2 10.7 1.3 1 1 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase FAM60A PF15396.6 CDI74967.1 - 5.2 7.0 17.2 5.5 6.9 17.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A MRP-S31 PF15433.6 CDI74967.1 - 5.3 6.6 24.0 6 6.5 24.0 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 CLN3 PF02487.17 CDI74967.1 - 7.1 5.6 15.3 7.1 5.6 15.3 1.1 1 0 0 1 1 1 0 CLN3 protein SID-1_RNA_chan PF13965.6 CDI74967.1 - 7.2 4.9 9.3 7.2 4.9 9.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Peptidase_S15 PF02129.18 CDI74967.1 - 8.9 5.8 18.2 11 5.5 18.2 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Neur_chan_memb PF02932.16 CDI74967.1 - 9 6.3 16.4 9.2 6.2 16.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Paf1 PF03985.13 CDI74967.1 - 9 5.2 22.7 10 5.0 22.7 1.1 1 0 0 1 1 1 0 Paf1 Gti1_Pac2 PF09729.9 CDI74967.1 - 9.9 6.2 16.3 11 6.1 16.3 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Ribosomal_60s PF00428.19 CDI74968.1 - 4.2 8.0 8.7 1.9 9.1 6.0 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein Orf78 PF06024.12 CDI74970.1 - 0.0034 17.7 5.5 0.0052 17.1 5.5 1.3 1 0 0 1 1 1 1 Orf78 (ac78) Afi1 PF07792.12 CDI74970.1 - 0.0085 16.6 8.8 0.0093 16.5 8.8 1.1 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF913 PF06025.12 CDI74970.1 - 0.01 14.8 5.3 0.012 14.6 5.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Pex14_N PF04695.13 CDI74970.1 - 0.013 16.2 15.2 0.015 16.0 15.2 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region eIF-3_zeta PF05091.12 CDI74970.1 - 0.014 14.4 13.8 0.014 14.4 13.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI74970.1 - 0.015 15.4 34.1 0.016 15.2 34.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EIIBC-GUT_N PF03612.14 CDI74970.1 - 0.017 14.9 8.3 0.02 14.6 8.3 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CobT PF06213.12 CDI74970.1 - 0.019 14.3 16.7 0.022 14.1 16.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Suf PF05843.14 CDI74970.1 - 0.026 14.5 15.0 0.035 14.1 15.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CPSF100_C PF13299.6 CDI74970.1 - 0.037 14.2 6.8 0.042 14.0 6.8 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RskA PF10099.9 CDI74970.1 - 0.042 14.1 8.4 0.11 12.8 8.4 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI74970.1 - 0.05 12.4 11.7 0.049 12.4 11.7 1.1 1 0 0 1 1 1 0 Presenilin DUF4471 PF14740.6 CDI74970.1 - 0.063 12.5 8.6 0.07 12.3 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) RR_TM4-6 PF06459.12 CDI74970.1 - 0.063 13.1 12.3 0.071 12.9 12.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF853 PF05872.12 CDI74970.1 - 0.066 11.8 10.3 0.073 11.7 10.3 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) EOS1 PF12326.8 CDI74970.1 - 0.074 13.0 4.2 0.086 12.8 4.2 1.2 1 0 0 1 1 1 0 N-glycosylation protein TERB2 PF15101.6 CDI74970.1 - 0.085 12.9 17.7 0.1 12.6 17.7 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF433 PF04255.14 CDI74970.1 - 0.086 12.7 0.2 0.14 12.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF433) V_ATPase_I PF01496.19 CDI74970.1 - 0.088 10.7 12.0 0.1 10.5 12.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SpoIIP PF07454.11 CDI74970.1 - 0.09 12.2 11.4 0.097 12.1 11.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FAM60A PF15396.6 CDI74970.1 - 0.096 12.7 7.3 0.11 12.5 7.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DDHD PF02862.17 CDI74970.1 - 0.11 12.6 9.5 0.11 12.6 9.5 1.1 1 0 0 1 1 1 0 DDHD domain Connexin PF00029.19 CDI74970.1 - 0.12 12.1 10.6 0.15 11.8 10.6 1.1 1 0 0 1 1 1 0 Connexin Neur_chan_memb PF02932.16 CDI74970.1 - 0.15 12.1 7.3 0.15 12.1 7.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HCO3_cotransp PF00955.21 CDI74970.1 - 0.18 10.6 2.7 0.19 10.5 2.7 1.0 1 0 0 1 1 1 0 HCO3- transporter family Baculo_PP31 PF05311.11 CDI74970.1 - 0.19 11.2 13.3 0.23 10.9 13.3 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) PAT1 PF09770.9 CDI74970.1 - 0.22 9.8 22.5 0.25 9.6 22.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CLN3 PF02487.17 CDI74970.1 - 0.23 10.5 9.5 0.26 10.3 9.5 1.1 1 0 0 1 1 1 0 CLN3 protein Peroxin-13_N PF04088.13 CDI74970.1 - 0.25 11.6 6.2 0.31 11.3 6.2 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region PPL5 PF18168.1 CDI74970.1 - 0.3 10.3 8.3 0.36 10.1 8.3 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF2828 PF11443.8 CDI74970.1 - 0.3 9.1 13.8 0.34 8.9 13.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) AIF_C PF14721.6 CDI74970.1 - 0.31 11.4 6.1 0.36 11.2 6.1 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF3347 PF11827.8 CDI74970.1 - 0.36 11.0 14.2 0.49 10.5 14.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Peptidase_S49_N PF08496.10 CDI74970.1 - 0.37 10.8 13.9 0.46 10.5 13.9 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal BRF1 PF07741.13 CDI74970.1 - 0.38 11.1 11.3 0.66 10.3 11.3 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DUF2347 PF09804.9 CDI74970.1 - 0.43 10.1 9.1 0.49 9.9 9.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) SID-1_RNA_chan PF13965.6 CDI74970.1 - 0.46 8.8 4.5 0.45 8.9 4.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GREB1 PF15782.5 CDI74970.1 - 0.52 7.4 15.1 0.52 7.4 15.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Band_3_cyto PF07565.13 CDI74970.1 - 0.58 9.9 12.6 0.65 9.7 12.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4746 PF15928.5 CDI74970.1 - 0.6 9.5 6.7 0.65 9.4 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Serinc PF03348.15 CDI74970.1 - 0.66 8.8 5.1 0.61 8.9 5.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Peptidase_S15 PF02129.18 CDI74970.1 - 0.83 9.2 8.6 0.96 9.0 8.6 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Ureide_permease PF07168.11 CDI74970.1 - 0.86 8.3 5.2 0.98 8.1 5.2 1.1 1 0 0 1 1 1 0 Ureide permease Sec62 PF03839.16 CDI74970.1 - 0.94 8.9 9.0 1.1 8.7 9.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Peptidase_U57 PF05582.12 CDI74970.1 - 0.95 8.7 9.0 1 8.5 9.0 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Ctr PF04145.15 CDI74970.1 - 0.96 10.1 8.8 1.2 9.8 8.8 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Zip PF02535.22 CDI74970.1 - 0.98 8.6 4.7 1.1 8.4 4.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Kei1 PF08552.11 CDI74970.1 - 1 9.2 5.4 1.4 8.7 5.4 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 CSG2 PF16965.5 CDI74970.1 - 1.2 8.0 8.4 1.4 7.8 8.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator GNAT_acetyltr_2 PF13718.6 CDI74970.1 - 1.6 8.1 11.9 2.1 7.7 11.9 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Nucleoside_tran PF01733.18 CDI74970.1 - 1.7 7.9 6.8 2.1 7.6 6.8 1.1 1 0 0 1 1 1 0 Nucleoside transporter NEMP PF10225.9 CDI74970.1 - 1.9 8.1 5.6 2.2 7.9 5.6 1.3 1 0 0 1 1 1 0 NEMP family Membralin PF09746.9 CDI74970.1 - 2.1 7.3 10.5 2.4 7.1 10.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein ALMT PF11744.8 CDI74970.1 - 2.6 6.8 12.3 2.7 6.7 12.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4407 PF14362.6 CDI74970.1 - 2.8 7.2 17.2 3.3 7.0 17.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Scs3p PF10261.9 CDI74970.1 - 3.6 7.0 6.1 4.6 6.7 6.1 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM PepSY_TM PF03929.16 CDI74970.1 - 3.8 7.1 5.4 4.1 7.0 5.4 1.2 1 0 0 1 1 1 0 PepSY-associated TM region OATP PF03137.20 CDI74970.1 - 4.7 5.4 9.6 5.4 5.2 9.6 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CRF1 PF10380.9 CDI74970.1 - 5.5 7.4 7.6 8.2 6.8 7.6 1.3 1 0 0 1 1 1 0 Transcription factor CRF1 SprA-related PF12118.8 CDI74970.1 - 6.9 5.7 25.4 8.3 5.4 25.4 1.2 1 0 0 1 1 1 0 SprA-related family DUF3464 PF11947.8 CDI74970.1 - 8.7 6.1 15.7 12 5.6 15.7 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 YABBY PF04690.13 CDI74970.1 - 9.1 6.8 11.7 12 6.4 11.7 1.2 1 0 0 1 1 1 0 YABBY protein Glt_symporter PF03616.14 CDI74970.1 - 9.6 4.8 5.7 13 4.4 5.7 1.3 1 0 0 1 1 1 0 Sodium/glutamate symporter Macoilin PF09726.9 CDI74971.1 - 6.1e-05 21.8 48.7 6.1e-05 21.8 48.7 5.0 4 1 0 4 4 4 2 Macoilin family zf-CCHC_2 PF13696.6 CDI74972.1 - 1e-08 34.8 3.7 1.5e-08 34.3 3.7 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 CDI74972.1 - 0.007 16.4 5.0 0.014 15.4 5.0 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 CDI74972.1 - 0.051 13.3 0.6 0.084 12.6 0.6 1.3 1 0 0 1 1 1 0 Zinc knuckle Med15 PF09606.10 CDI74972.1 - 0.22 10.2 32.0 0.06 12.0 7.3 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal CrgA PF06781.12 CDI74972.1 - 3 8.0 6.0 3.5 7.8 0.3 2.6 2 0 0 2 2 2 0 Cell division protein CrgA RskA PF10099.9 CDI74972.1 - 3.4 7.9 44.9 0.32 11.3 6.5 3.3 2 1 1 3 3 3 0 Anti-sigma-K factor rskA DUF3408 PF11888.8 CDI74972.1 - 4.5 7.4 9.7 11 6.2 1.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) SID-1_RNA_chan PF13965.6 CDI74973.1 - 0.041 12.3 7.7 0.04 12.3 7.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PAT1 PF09770.9 CDI74973.1 - 0.5 8.6 47.0 0.57 8.4 47.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Lin-8 PF03353.15 CDI74973.1 - 1.3 8.5 27.2 1.6 8.2 27.2 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Utp14 PF04615.13 CDI74973.1 - 2.7 6.5 32.0 3 6.3 32.0 1.1 1 0 0 1 1 1 0 Utp14 protein CDC27 PF09507.10 CDI74973.1 - 2.9 7.2 35.0 3.4 6.9 35.0 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Band_3_cyto PF07565.13 CDI74973.1 - 3.7 7.3 32.7 5.9 6.6 32.7 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SLC12 PF03522.15 CDI74973.1 - 3.8 6.4 26.9 4.2 6.3 26.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 V_ATPase_I PF01496.19 CDI74973.1 - 3.9 5.3 28.8 4.6 5.0 28.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GAGA_bind PF06217.12 CDI74973.1 - 4.9 7.4 23.3 5.6 7.2 23.3 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family eIF3_subunit PF08597.10 CDI74976.1 - 2 8.3 10.3 3 7.7 10.3 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit TFIIA PF03153.13 CDI74976.1 - 4.1 7.3 12.0 5 7.0 12.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DcuA_DcuB PF03605.14 CDI74977.1 - 0.00066 18.7 1.3 0.00066 18.7 1.3 6.7 5 2 2 7 7 7 2 Anaerobic c4-dicarboxylate membrane transporter Med15 PF09606.10 CDI74977.1 - 0.0037 16.0 8.9 0.0037 16.0 8.9 7.8 3 2 5 8 8 8 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2722 PF10846.8 CDI74978.1 - 0.0063 15.5 8.7 0.0063 15.5 8.7 6.0 2 1 2 4 4 4 1 Protein of unknown function (DUF2722) Ion_trans PF00520.31 CDI74979.1 - 0.00019 20.8 9.5 0.00026 20.3 9.5 1.1 1 0 0 1 1 1 1 Ion transport protein TFIIA PF03153.13 CDI74980.1 - 0.00032 20.8 26.8 0.00044 20.4 26.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2076 PF09849.9 CDI74980.1 - 0.0061 16.6 21.1 0.0093 16.0 21.1 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Pex14_N PF04695.13 CDI74980.1 - 0.015 16.0 10.4 0.015 16.0 10.4 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 CDI74980.1 - 0.094 12.3 33.1 0.075 12.6 26.4 2.1 2 0 0 2 2 2 0 Spt20 family Mif2_N PF15624.6 CDI74980.1 - 0.63 10.7 15.4 0.14 12.9 0.8 2.5 3 0 0 3 3 2 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal TagA PF12561.8 CDI74980.1 - 0.82 10.1 5.9 0.28 11.6 1.4 2.2 2 0 0 2 2 2 0 ToxR activated gene A lipoprotein domain DUF4175 PF13779.6 CDI74980.1 - 0.88 7.4 23.7 1.5 6.6 23.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Afi1 PF07792.12 CDI74980.1 - 0.96 9.9 12.6 0.96 9.9 6.5 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Bul1_N PF04425.12 CDI74980.1 - 1.1 7.9 14.1 0.52 9.0 6.6 2.1 2 0 0 2 2 2 0 Bul1 N terminus FAM176 PF14851.6 CDI74980.1 - 1.2 8.8 10.2 5.3 6.7 5.8 2.3 2 0 0 2 2 2 0 FAM176 family FAM60A PF15396.6 CDI74980.1 - 1.7 8.6 14.9 1.6 8.6 1.1 2.2 2 0 0 2 2 2 0 Protein Family FAM60A VIT1 PF01988.19 CDI74980.1 - 2 8.2 8.6 0.38 10.6 4.2 1.9 2 0 0 2 2 2 0 VIT family PEX11 PF05648.14 CDI74980.1 - 2.5 7.5 8.6 1.3 8.4 4.5 2.0 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) RPN2_C PF18004.1 CDI74980.1 - 2.6 7.9 12.3 1.6 8.6 8.1 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4407 PF14362.6 CDI74980.1 - 2.9 7.1 14.1 3.8 6.8 14.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SR-25 PF10500.9 CDI74980.1 - 4.2 6.9 36.0 1.8 8.1 19.8 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF572 PF04502.13 CDI74980.1 - 4.9 6.7 16.7 7.4 6.1 16.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4598 PF15370.6 CDI74980.1 - 6.8 7.2 13.2 5.8 7.4 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4598) DUF3138 PF11336.8 CDI74980.1 - 7.4 5.1 12.5 12 4.4 12.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Rxt3 PF08642.10 CDI74980.1 - 8.5 7.2 9.5 18 6.1 4.9 2.2 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 DUF1117 PF06547.12 CDI74980.1 - 8.7 6.9 11.0 8.4 7.0 3.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) RNA_pol_Rbc25 PF08292.12 CDI74980.1 - 8.7 6.6 8.8 2.7 8.2 3.1 2.2 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 Band_3_cyto PF07565.13 CDI74980.1 - 9.1 6.0 19.4 8.7 6.1 9.5 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF1980 PF09323.10 CDI74980.1 - 10 6.0 7.7 9 6.2 2.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Spt20 PF12090.8 CDI74981.1 - 0.002 17.8 11.5 0.002 17.8 11.5 2.8 3 0 0 3 3 3 1 Spt20 family TFIIA PF03153.13 CDI74982.1 - 0.007 16.4 74.2 0.012 15.7 74.2 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI74982.1 - 0.032 12.5 48.4 0.042 12.1 48.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AIF_C PF14721.6 CDI74982.1 - 0.51 10.7 0.0 0.51 10.7 0.0 3.2 1 1 2 3 3 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term GREB1 PF15782.5 CDI74982.1 - 0.52 7.4 33.4 0.69 7.0 33.4 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Med15 PF09606.10 CDI74982.1 - 0.69 8.5 64.8 1.1 7.8 64.8 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Smg8_Smg9 PF10220.9 CDI74982.1 - 1.1 7.4 27.8 1.7 6.8 27.8 1.4 1 0 0 1 1 1 0 Smg8_Smg9 Sin_N PF04801.13 CDI74982.1 - 1.2 8.3 46.0 2 7.6 46.0 1.4 1 0 0 1 1 1 0 Sin-like protein conserved region Hid1 PF12722.7 CDI74982.1 - 3 5.8 38.1 3.9 5.5 38.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AAA_11 PF13086.6 CDI74982.1 - 3 7.5 34.9 4.6 6.9 34.9 1.3 1 0 0 1 1 1 0 AAA domain CDK5_activator PF03261.15 CDI74982.1 - 4.9 6.6 28.0 6.3 6.2 28.0 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Nucleo_P87 PF07267.11 CDI74982.1 - 6.2 5.5 27.4 8.5 5.1 27.4 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Exonuc_VII_L PF02601.15 CDI74982.1 - 6.3 6.3 36.0 14 5.2 36.0 1.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit LMBR1 PF04791.16 CDI74982.1 - 6.5 5.5 13.5 9.1 5.0 13.5 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Zip PF02535.22 CDI74983.1 - 1.9 7.6 12.7 3.5 6.7 12.7 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Pkinase PF00069.25 CDI74984.1 - 6.5e-21 74.9 0.9 4.7e-15 55.7 0.4 2.9 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI74984.1 - 6.4e-10 38.7 0.4 3.7e-07 29.7 0.2 3.0 2 1 1 3 3 3 2 Protein tyrosine kinase NCA2 PF08637.10 CDI74985.1 - 0.047 12.8 3.3 0.069 12.3 3.3 1.1 1 0 0 1 1 1 0 ATP synthase regulation protein NCA2 DUF1772 PF08592.11 CDI74986.1 - 3.1 8.1 17.0 5.5 7.3 3.7 5.0 5 0 0 5 5 5 0 Domain of unknown function (DUF1772) RPN1_RPN2_N PF17781.1 CDI74987.1 - 1e-112 376.5 1.9 1.5e-112 376.0 1.9 1.3 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 CDI74987.1 - 8.5e-27 93.0 0.1 1.7e-26 92.0 0.1 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 CDI74987.1 - 6.7e-13 48.4 36.8 0.00027 21.2 0.2 8.8 9 0 0 9 9 9 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CDI74987.1 - 0.041 14.3 9.9 0.12 12.8 0.1 5.2 5 1 0 5 5 5 0 HEAT repeats PI3_PI4_kinase PF00454.27 CDI74989.1 - 2.7e-33 115.8 0.0 4.3e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF4770 PF15994.5 CDI74990.1 - 0.00018 21.8 7.4 0.00035 20.9 4.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4770) DUF1980 PF09323.10 CDI74990.1 - 0.00031 20.7 0.3 0.00063 19.7 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1980) DUF4834 PF16118.5 CDI74990.1 - 0.0025 18.7 0.7 0.0025 18.7 0.7 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) GT87 PF09594.10 CDI74990.1 - 0.0064 16.2 3.6 0.0064 16.2 3.6 3.5 2 1 0 2 2 1 1 Glycosyltransferase family 87 Mlh1_C PF16413.5 CDI74990.1 - 0.0084 15.5 0.7 0.018 14.4 0.7 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DUF3452 PF11934.8 CDI74990.1 - 0.009 15.6 1.1 0.017 14.6 1.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3452) Pex26 PF07163.12 CDI74990.1 - 0.012 14.9 12.8 0.031 13.6 5.7 2.4 2 0 0 2 2 2 0 Pex26 protein ANAPC_CDC26 PF10471.9 CDI74990.1 - 0.021 15.6 16.9 0.021 15.6 16.9 3.3 2 1 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Band_3_cyto PF07565.13 CDI74990.1 - 0.14 11.9 2.8 0.22 11.3 0.4 2.0 2 0 0 2 2 2 0 Band 3 cytoplasmic domain CPSF100_C PF13299.6 CDI74990.1 - 0.14 12.3 6.3 0.43 10.7 0.1 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 CDI74990.1 - 0.21 10.3 7.1 0.06 12.1 0.2 2.1 2 0 0 2 2 2 0 Presenilin MPM1 PF17234.2 CDI74990.1 - 0.21 11.8 9.7 0.037 14.3 4.6 1.9 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 BRF1 PF07741.13 CDI74990.1 - 0.24 11.8 0.1 0.24 11.8 0.1 2.5 2 1 0 2 2 2 0 Brf1-like TBP-binding domain PigN PF04987.14 CDI74990.1 - 0.59 8.9 1.2 0.95 8.2 1.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) CLN3 PF02487.17 CDI74990.1 - 0.96 8.4 4.2 0.22 10.5 0.4 1.7 2 0 0 2 2 2 0 CLN3 protein Insulin PF00049.18 CDI74990.1 - 1.5 9.9 8.6 1.4 10.0 5.0 2.4 2 0 0 2 2 2 0 Insulin/IGF/Relaxin family PAPA-1 PF04795.12 CDI74990.1 - 4.8 8.0 13.0 1.9 9.4 2.4 3.0 2 1 0 2 2 2 0 PAPA-1-like conserved region Conotoxin PF02950.17 CDI74990.1 - 5.2 8.2 8.8 1.4 10.0 3.7 2.5 2 0 0 2 2 2 0 Conotoxin DUF4834 PF16118.5 CDI74992.1 - 0.0065 17.4 3.6 0.011 16.7 3.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) RR_TM4-6 PF06459.12 CDI74992.1 - 0.039 13.8 5.1 0.049 13.5 5.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spt20 PF12090.8 CDI74992.1 - 0.1 12.2 16.8 0.16 11.6 16.8 1.3 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI74992.1 - 0.34 10.8 22.3 0.4 10.6 22.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1980 PF09323.10 CDI74992.1 - 0.79 9.6 2.2 1.1 9.1 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Activator_LAG-3 PF11498.8 CDI74992.1 - 1.2 8.1 20.3 1.9 7.4 20.3 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Myc_N PF01056.18 CDI74992.1 - 1.3 8.8 9.9 1.6 8.6 9.9 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Presenilin PF01080.17 CDI74992.1 - 2.6 6.7 6.1 2.6 6.7 6.1 1.2 1 0 0 1 1 1 0 Presenilin UPF0560 PF10577.9 CDI74992.1 - 4.1 5.8 8.2 5.7 5.3 8.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF5349 PF17298.2 CDI74992.1 - 4.5 6.9 12.7 0.28 10.9 1.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5349) DUF2722 PF10846.8 CDI74992.1 - 5.1 5.9 16.0 7.9 5.3 16.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Roughex PF06020.11 CDI74992.1 - 5.4 6.0 15.1 11 5.0 15.1 1.5 1 1 0 1 1 1 0 Drosophila roughex protein Med15 PF09606.10 CDI74992.1 - 7.1 5.2 24.3 9.2 4.8 24.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SR-25 PF10500.9 CDI74993.1 - 0.0091 15.6 7.5 0.0091 15.6 7.5 1.4 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Ion_trans PF00520.31 CDI74994.1 - 3e-41 141.3 57.2 6.5e-16 58.3 7.3 4.2 4 0 0 4 4 4 4 Ion transport protein Sarcoglycan_1 PF04790.13 CDI74994.1 - 0.12 11.7 0.4 0.27 10.5 0.4 1.6 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein DUF2484 PF10658.9 CDI74994.1 - 6.2 7.2 11.8 0.14 12.5 1.8 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2484) Activator_LAG-3 PF11498.8 CDI74995.1 - 0.001 18.1 11.7 0.001 18.1 11.7 4.1 4 0 0 4 4 4 1 Transcriptional activator LAG-3 Utp14 PF04615.13 CDI74996.1 - 3.2 6.2 54.3 4.6 5.7 54.3 1.1 1 0 0 1 1 1 0 Utp14 protein TFIIA PF03153.13 CDI74997.1 - 0.059 13.4 47.9 0.076 13.0 47.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1387 PF07139.11 CDI74997.1 - 0.19 11.4 17.8 0.2 11.3 17.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Band_3_cyto PF07565.13 CDI74997.1 - 0.23 11.2 14.2 0.25 11.1 14.2 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PRCH PF03967.13 CDI74997.1 - 0.39 10.9 8.7 0.45 10.8 8.2 1.3 1 1 0 1 1 1 0 Photosynthetic reaction centre, H-chain N-terminal region Lin-8 PF03353.15 CDI74997.1 - 0.39 10.2 21.4 0.42 10.1 21.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DDRGK PF09756.9 CDI74997.1 - 0.43 10.2 21.0 0.48 10.0 21.0 1.3 1 0 0 1 1 1 0 DDRGK domain V_ATPase_I PF01496.19 CDI74997.1 - 0.51 8.2 16.4 0.49 8.2 16.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4638 PF15472.6 CDI74997.1 - 1.3 8.7 16.0 1.5 8.5 16.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Membralin PF09746.9 CDI74997.1 - 2.1 7.3 11.5 2.3 7.2 11.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein ALMT PF11744.8 CDI74997.1 - 2.9 6.6 15.2 3.2 6.5 15.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 CDI74997.1 - 3 7.8 19.0 3.5 7.6 19.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF45 PF01863.17 CDI74997.1 - 3.3 7.7 13.6 4 7.4 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF45 SLC12 PF03522.15 CDI74997.1 - 3.4 6.6 20.8 3.8 6.4 20.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 GPCR_chapero_1 PF11904.8 CDI74997.1 - 3.7 6.9 11.5 4 6.8 11.5 1.2 1 0 0 1 1 1 0 GPCR-chaperone Miga PF10265.9 CDI74997.1 - 3.9 6.3 15.1 4.7 6.1 15.1 1.0 1 0 0 1 1 1 0 Mitoguardin PepSY_TM_like_2 PF16357.5 CDI74997.1 - 4.3 7.3 13.6 5.3 7.0 13.6 1.3 1 0 0 1 1 1 0 Putative PepSY_TM-like Mem_trans PF03547.18 CDI74997.1 - 4.7 5.5 7.2 5.6 5.3 7.2 1.1 1 0 0 1 1 1 0 Membrane transport protein UPF0560 PF10577.9 CDI74997.1 - 5 5.5 26.6 5.5 5.4 26.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Connexin PF00029.19 CDI74997.1 - 5.5 6.7 11.9 6.9 6.3 11.9 1.3 1 0 0 1 1 1 0 Connexin NPR3 PF03666.13 CDI74997.1 - 6.2 5.5 16.7 7.6 5.2 16.7 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Draxin PF15550.6 CDI74997.1 - 6.8 6.5 15.2 9.8 5.9 15.2 1.2 1 0 0 1 1 1 0 Draxin Pannexin_like PF12534.8 CDI74997.1 - 7.3 5.6 12.1 8 5.4 12.1 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 PA26 PF04636.13 CDI74997.1 - 9.2 5.1 14.8 10 4.9 14.8 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Endonuc_Holl PF10107.9 CDI74997.1 - 9.3 6.1 12.5 15 5.4 12.5 1.4 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase DUF2722 PF10846.8 CDI74999.1 - 0.008 15.2 1.4 0.008 15.2 1.4 4.3 3 1 1 4 4 4 1 Protein of unknown function (DUF2722) DUF4207 PF13904.6 CDI74999.1 - 0.048 13.4 0.4 0.048 13.4 0.4 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4207) CPSF100_C PF13299.6 CDI74999.1 - 0.092 12.9 23.8 1.4 9.1 9.8 4.1 4 0 0 4 4 4 0 Cleavage and polyadenylation factor 2 C-terminal Serinc PF03348.15 CDI74999.1 - 0.26 10.2 14.3 0.26 10.2 0.2 2.9 3 0 0 3 3 3 0 Serine incorporator (Serinc) XRN1_D2_D3 PF18334.1 CDI74999.1 - 0.51 10.6 0.0 0.51 10.6 0.0 3.3 2 1 1 3 3 3 0 Exoribonuclease Xrn1 D2/D3 domain Mit_KHE1 PF10173.9 CDI74999.1 - 3.8 7.5 10.8 10 6.1 5.5 2.7 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related Gaa1 PF04114.14 CDI74999.1 - 7.4 5.5 11.8 0.8 8.6 0.1 3.1 3 0 0 3 3 3 0 Gaa1-like, GPI transamidase component PAXIP1_C PF15364.6 CDI75001.1 - 0.0037 17.6 0.2 1.5 9.1 0.0 2.1 2 0 0 2 2 2 1 PAXIP1-associated-protein-1 C term PTIP binding protein Presenilin PF01080.17 CDI75001.1 - 0.0043 15.9 4.7 0.0061 15.4 4.7 1.2 1 0 0 1 1 1 1 Presenilin DUF4834 PF16118.5 CDI75001.1 - 0.0077 17.2 6.5 0.82 10.7 2.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) DUF2828 PF11443.8 CDI75001.1 - 0.013 13.7 2.5 0.016 13.4 2.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Ndc1_Nup PF09531.10 CDI75001.1 - 0.014 14.1 15.8 0.016 13.9 15.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PIP5K PF01504.18 CDI75001.1 - 0.021 14.0 0.3 0.026 13.7 0.3 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Pex14_N PF04695.13 CDI75001.1 - 0.028 15.1 33.0 0.13 13.0 5.0 2.1 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region dsDNA_bind PF01984.20 CDI75001.1 - 0.055 13.8 17.8 0.53 10.6 2.0 2.3 2 0 0 2 2 2 0 Double-stranded DNA-binding domain DUF4366 PF14283.6 CDI75001.1 - 0.058 13.4 9.3 0.68 10.0 5.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) MMU163 PF17119.5 CDI75001.1 - 0.1 11.7 0.4 0.88 8.7 0.1 2.0 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis AUX_IAA PF02309.16 CDI75001.1 - 0.17 11.7 5.8 0.23 11.3 5.8 1.2 1 0 0 1 1 1 0 AUX/IAA family Shisa PF13908.6 CDI75001.1 - 0.21 11.8 0.1 0.21 11.8 0.1 2.8 1 1 1 3 3 3 0 Wnt and FGF inhibitory regulator SpoIIP PF07454.11 CDI75001.1 - 0.24 10.8 5.1 0.54 9.7 0.7 2.0 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) FAM199X PF15814.5 CDI75001.1 - 0.47 9.5 12.0 0.032 13.3 7.2 1.4 1 1 0 1 1 1 0 Protein family FAM199X DUF1980 PF09323.10 CDI75001.1 - 0.62 10.0 6.1 0.44 10.4 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) tRNA_lig_CPD PF08302.11 CDI75001.1 - 0.67 9.4 7.1 5.9 6.3 0.1 2.1 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain Orf78 PF06024.12 CDI75001.1 - 0.97 9.8 4.0 4.4 7.7 1.1 2.3 2 1 0 2 2 2 0 Orf78 (ac78) DUF4569 PF15133.6 CDI75001.1 - 1.3 8.7 9.5 0.98 9.1 2.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4569) Rpp20 PF12328.8 CDI75001.1 - 1.4 8.9 7.0 1.3 9.0 0.9 2.1 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P COX4 PF02936.14 CDI75001.1 - 1.4 9.0 7.5 2.1 8.4 0.5 2.5 2 1 1 3 3 3 0 Cytochrome c oxidase subunit IV DUF4064 PF13273.6 CDI75001.1 - 2.6 8.4 6.5 2.8 8.3 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) SRP-alpha_N PF04086.13 CDI75001.1 - 4.2 7.2 13.4 5.6 6.8 13.4 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RNA_pol_Rbc25 PF08292.12 CDI75001.1 - 4.7 7.5 8.3 16 5.7 0.3 2.2 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 CrgA PF06781.12 CDI75001.1 - 4.7 7.3 4.7 52 4.0 0.0 2.5 2 1 1 3 3 3 0 Cell division protein CrgA Methyltransf_23 PF13489.6 CDI75001.1 - 5 6.9 5.7 13 5.6 0.3 2.1 2 0 0 2 2 2 0 Methyltransferase domain TERB2 PF15101.6 CDI75001.1 - 7.2 6.6 14.4 4.6 7.2 4.3 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 MSP1_C PF07462.11 CDI75001.1 - 7.4 5.1 7.1 8.8 4.9 7.1 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus AF-4 PF05110.13 CDI75003.1 - 0.00086 17.5 13.0 0.0011 17.2 13.0 1.1 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Mito_fiss_reg PF05308.11 CDI75003.1 - 0.003 17.7 10.0 0.0035 17.5 10.0 1.1 1 0 0 1 1 1 1 Mitochondrial fission regulator Syntaphilin PF15290.6 CDI75003.1 - 0.021 14.5 8.8 0.028 14.1 8.8 1.2 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp SR-25 PF10500.9 CDI75003.1 - 0.021 14.4 14.1 0.021 14.4 14.1 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein PRIMA1 PF16101.5 CDI75003.1 - 0.033 14.2 6.5 0.033 14.2 6.5 1.7 1 1 0 2 2 2 0 Proline-rich membrane anchor 1 DUF5423 PF17461.2 CDI75003.1 - 0.049 12.5 4.0 0.057 12.3 4.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5423) SARAF PF06682.12 CDI75003.1 - 0.057 13.1 8.5 0.24 11.0 8.5 1.7 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis CCSAP PF15748.5 CDI75003.1 - 0.064 13.4 5.6 0.08 13.1 5.6 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4834 PF16118.5 CDI75003.1 - 0.1 13.6 4.6 3.4 8.7 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) IMUP PF15761.5 CDI75003.1 - 0.11 13.2 12.0 0.27 11.9 12.0 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein TFIIA PF03153.13 CDI75003.1 - 0.13 12.2 13.5 0.16 11.9 13.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Activator_LAG-3 PF11498.8 CDI75003.1 - 0.15 11.0 16.7 0.21 10.5 16.7 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SelK_SelG PF10961.8 CDI75003.1 - 0.55 10.9 4.7 0.86 10.3 1.0 2.0 2 0 0 2 2 2 0 Selenoprotein SelK_SelG Conotoxin PF02950.17 CDI75003.1 - 2.1 9.4 4.6 19 6.4 2.8 2.1 2 0 0 2 2 2 0 Conotoxin Ndc1_Nup PF09531.10 CDI75003.1 - 4 6.0 12.6 4.9 5.7 12.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup EphA2_TM PF14575.6 CDI75003.1 - 5 8.1 4.9 5.4 8.0 0.7 2.2 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain YqzL PF14006.6 CDI75003.1 - 5.5 7.4 5.3 14 6.1 5.3 1.6 1 0 0 1 1 1 0 YqzL-like protein CAP_N PF01213.19 CDI75003.1 - 9.9 5.5 16.1 21 4.5 16.1 1.6 1 1 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Syntaxin-18_N PF10496.9 CDI75004.1 - 0.043 14.1 0.4 0.043 14.1 0.4 2.5 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus HNOBA PF07701.14 CDI75005.1 - 0.15 11.5 6.5 0.58 9.5 0.3 2.3 2 0 0 2 2 2 0 Heme NO binding associated Tim54 PF11711.8 CDI75005.1 - 0.16 10.7 7.6 0.46 9.2 1.7 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Spt20 PF12090.8 CDI75005.1 - 0.25 10.9 50.8 0.48 10.0 16.8 2.4 2 0 0 2 2 2 0 Spt20 family CPSF100_C PF13299.6 CDI75005.1 - 0.26 11.5 14.7 0.28 11.4 2.5 2.7 3 0 0 3 3 2 0 Cleavage and polyadenylation factor 2 C-terminal PAT1 PF09770.9 CDI75005.1 - 0.41 8.9 30.1 0.77 7.9 14.7 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.10 CDI75005.1 - 0.5 9.0 44.6 0.1 11.3 20.4 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal EPL1 PF10513.9 CDI75005.1 - 0.6 10.5 17.9 0.26 11.6 2.5 2.5 3 0 0 3 3 2 0 Enhancer of polycomb-like DUF4787 PF16029.5 CDI75005.1 - 0.73 10.0 5.5 0.16 12.1 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4787) Sec62 PF03839.16 CDI75005.1 - 1.7 8.1 12.3 0.58 9.6 1.0 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 DUF3381 PF11861.8 CDI75005.1 - 1.7 8.4 19.4 0.94 9.3 2.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) SLC12 PF03522.15 CDI75005.1 - 1.7 7.5 15.2 1.5 7.8 2.8 2.1 2 0 0 2 2 2 0 Solute carrier family 12 DUF702 PF05142.12 CDI75005.1 - 2 8.9 24.3 1.3 9.4 7.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Suf PF05843.14 CDI75005.1 - 2.6 7.9 22.9 0.79 9.7 2.5 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) RR_TM4-6 PF06459.12 CDI75005.1 - 4.4 7.1 15.9 3 7.6 4.1 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 SPX PF03105.19 CDI75005.1 - 5 6.9 21.8 1.7 8.5 8.4 2.1 2 0 0 2 2 2 0 SPX domain PIP5K PF01504.18 CDI75005.1 - 5.5 6.1 15.4 2.9 7.0 2.3 2.3 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase ALMT PF11744.8 CDI75005.1 - 6.7 5.4 13.2 5.7 5.7 1.9 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter DUF4638 PF15472.6 CDI75005.1 - 7.7 6.2 16.0 3.3 7.4 1.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) 3HCDH_N PF02737.18 CDI75005.1 - 9.1 6.1 12.0 0.31 10.9 3.6 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain CybS PF05328.12 CDI75006.1 - 1.5 8.5 4.6 0.53 10.0 1.4 1.9 1 1 0 1 1 1 0 CybS, succinate dehydrogenase cytochrome B small subunit DUF3533 PF12051.8 CDI75006.1 - 2.5 6.9 27.6 3.1 6.6 27.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) BAF1_ABF1 PF04684.13 CDI75006.1 - 3.4 6.6 39.2 2.3 7.2 37.3 1.6 1 1 1 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor DDOST_48kD PF03345.14 CDI75009.1 - 4.4e-32 111.4 0.0 1.2e-30 106.7 0.0 2.4 2 1 0 2 2 2 1 Oligosaccharyltransferase 48 kDa subunit beta RskA PF10099.9 CDI75010.1 - 0.00083 19.7 15.7 0.00083 19.7 15.7 5.1 3 2 2 5 5 5 2 Anti-sigma-K factor rskA Suf PF05843.14 CDI75010.1 - 2.1 8.3 7.3 2.3 8.1 3.4 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) SR-25 PF10500.9 CDI75010.1 - 5.7 6.5 15.7 0.34 10.5 4.5 2.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI75015.1 - 2.6e-05 24.6 13.0 2.6e-05 24.6 13.0 13.6 3 3 2 5 5 5 2 Anti-sigma-K factor rskA LRR_8 PF13855.6 CDI75015.1 - 0.009 15.8 1.3 0.024 14.4 1.3 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 CDI75015.1 - 0.036 14.5 1.5 0.098 13.1 1.5 1.7 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) EVI2A PF05399.11 CDI75016.1 - 0.00099 18.8 4.4 0.0017 18.0 4.4 1.3 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) OAD_gamma PF04277.13 CDI75016.1 - 0.011 16.3 0.2 0.011 16.3 0.2 5.1 5 1 1 6 6 3 0 Oxaloacetate decarboxylase, gamma chain Orf78 PF06024.12 CDI75016.1 - 0.016 15.5 0.2 0.016 15.5 0.2 3.1 3 1 0 3 3 3 0 Orf78 (ac78) CDC45 PF02724.14 CDI75016.1 - 0.017 13.4 0.1 0.017 13.4 0.1 1.5 2 0 0 2 2 2 0 CDC45-like protein Apt1 PF10351.9 CDI75016.1 - 0.031 13.1 1.2 0.034 13.0 1.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain BatD PF13584.6 CDI75016.1 - 0.044 12.6 0.5 0.21 10.4 0.1 2.1 2 0 0 2 2 2 0 Oxygen tolerance DUF2207 PF09972.9 CDI75016.1 - 0.21 10.3 0.0 0.3 9.8 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Mem_trans PF03547.18 CDI75016.1 - 0.78 8.1 3.1 3 6.1 3.8 1.4 1 1 0 1 1 1 0 Membrane transport protein PI3K_1B_p101 PF10486.9 CDI75016.1 - 1 7.1 8.0 1.3 6.8 8.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RRN3 PF05327.11 CDI75016.1 - 1.8 7.0 5.5 2.6 6.5 5.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Secretin_N_2 PF07655.13 CDI75016.1 - 9.6 6.8 12.2 18 6.0 12.2 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain DnaJ PF00226.31 CDI75017.1 - 7e-12 45.3 0.0 2.5e-11 43.5 0.0 2.0 1 0 0 1 1 1 1 DnaJ domain RskA PF10099.9 CDI75017.1 - 0.0032 17.8 10.4 0.0032 17.8 10.4 6.1 1 1 3 4 4 4 1 Anti-sigma-K factor rskA Utp14 PF04615.13 CDI75017.1 - 2.9 6.4 57.8 0.89 8.1 28.0 2.2 2 0 0 2 2 2 0 Utp14 protein RAP1 PF07218.11 CDI75017.1 - 2.9 6.1 31.2 0.04 12.2 8.1 2.2 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) DUF4131 PF13567.6 CDI75018.1 - 0.00014 21.6 0.3 0.00031 20.4 0.2 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4131) Spt20 PF12090.8 CDI75018.1 - 0.00014 21.5 34.8 0.00076 19.2 25.8 2.1 2 0 0 2 2 2 2 Spt20 family YfhO PF09586.10 CDI75018.1 - 0.0011 17.3 0.3 0.0011 17.3 0.3 1.3 1 0 0 1 1 1 1 Bacterial membrane protein YfhO HemX PF04375.14 CDI75018.1 - 0.0045 16.3 15.2 0.0045 16.3 15.2 2.0 2 0 0 2 2 2 1 HemX, putative uroporphyrinogen-III C-methyltransferase Phage_holin_3_6 PF07332.11 CDI75018.1 - 0.0048 16.9 0.9 0.0081 16.2 0.9 1.4 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III O-antigen_lig PF13425.6 CDI75018.1 - 0.0069 15.2 10.2 0.0094 14.8 9.1 1.8 1 1 0 1 1 1 1 O-antigen ligase like membrane protein RskA PF10099.9 CDI75018.1 - 0.0071 16.7 10.7 0.0071 16.7 10.7 2.2 1 1 1 2 2 2 1 Anti-sigma-K factor rskA Med19 PF10278.9 CDI75018.1 - 0.0074 16.2 3.8 0.0074 16.2 3.8 1.8 2 0 0 2 2 2 1 Mediator of RNA pol II transcription subunit 19 Cas1_AcylT PF07779.12 CDI75018.1 - 0.072 12.0 1.5 0.14 11.0 0.1 2.0 2 0 0 2 2 2 0 10 TM Acyl Transferase domain found in Cas1p SARAF PF06682.12 CDI75018.1 - 0.11 12.1 10.6 0.17 11.5 10.6 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis CLN3 PF02487.17 CDI75018.1 - 0.15 11.1 14.3 3.4 6.6 12.6 2.4 1 1 1 2 2 2 0 CLN3 protein BAT2_N PF07001.11 CDI75018.1 - 0.77 10.2 15.8 0.09 13.2 4.3 2.1 2 0 0 2 2 2 0 BAT2 N-terminus tRNA_anti-like PF12869.7 CDI75018.1 - 0.9 9.1 13.6 0.36 10.4 1.5 2.6 2 1 1 3 3 3 0 tRNA_anti-like Pex24p PF06398.11 CDI75018.1 - 0.93 8.4 7.4 1.4 7.8 0.1 2.1 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin SMYLE_N PF18615.1 CDI75018.1 - 1.5 8.3 16.8 1.9 7.9 16.8 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain PPP4R2 PF09184.11 CDI75018.1 - 1.6 8.2 18.9 0.61 9.6 14.8 1.9 2 0 0 2 2 2 0 PPP4R2 ABC2_membrane_2 PF12679.7 CDI75018.1 - 1.9 7.7 7.0 1.9 7.7 4.4 2.1 1 1 1 2 2 2 0 ABC-2 family transporter protein SID-1_RNA_chan PF13965.6 CDI75018.1 - 2.4 6.5 8.7 30 2.8 8.7 2.0 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 FCP1_C PF09309.10 CDI75018.1 - 2.6 7.8 20.9 0.21 11.4 14.1 2.1 2 0 0 2 2 2 0 FCP1, C-terminal eIF_4EBP PF05456.11 CDI75018.1 - 3.9 7.4 14.9 1.7 8.6 2.3 3.1 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) CBP_BcsG PF11658.8 CDI75018.1 - 4.5 5.6 13.8 0.09 11.2 5.5 2.1 1 1 2 3 3 3 0 Cellulose biosynthesis protein BcsG CSG2 PF16965.5 CDI75018.1 - 9.4 5.1 13.1 0.48 9.3 1.2 2.3 1 1 1 2 2 2 0 Ceramide synthase regulator TFIIA PF03153.13 CDI75019.1 - 0.013 15.6 24.7 0.013 15.6 24.7 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit FHIPEP PF00771.20 CDI75019.1 - 0.81 8.1 7.3 1.2 7.5 7.3 1.2 1 0 0 1 1 1 0 FHIPEP family FAM60A PF15396.6 CDI75019.1 - 1.7 8.6 6.2 3 7.8 6.2 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Coilin_N PF15862.5 CDI75019.1 - 2.5 7.9 12.0 4.4 7.1 12.0 1.3 1 0 0 1 1 1 0 Coilin N-terminus Neur_chan_memb PF02932.16 CDI75019.1 - 2.9 7.9 5.2 0.6 10.1 1.9 1.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region RskA PF10099.9 CDI75019.1 - 3.1 8.0 59.0 0.21 11.8 31.9 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI75019.1 - 3.4 6.5 11.9 4.6 6.1 11.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2722 PF10846.8 CDI75019.1 - 4.1 6.2 25.3 6.9 5.5 25.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) SpoIIP PF07454.11 CDI75019.1 - 4.9 6.5 9.6 8.7 5.7 9.6 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 CDI75019.1 - 5.7 6.6 4.8 8 6.1 4.8 1.1 1 0 0 1 1 1 0 Connexin Dehydrin PF00257.19 CDI75019.1 - 7.7 7.0 21.7 0.074 13.6 6.9 2.3 2 0 0 2 2 2 0 Dehydrin UPF0560 PF10577.9 CDI75019.1 - 9.5 4.6 14.1 14 4.0 14.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Endonuclease_NS PF01223.23 CDI75020.1 - 2.8e-06 27.3 0.0 3.4e-05 23.8 0.0 2.4 1 1 0 1 1 1 1 DNA/RNA non-specific endonuclease SNase PF00565.17 CDI75022.1 - 4.8e-10 39.9 2.0 4.3e-05 24.0 0.0 3.2 3 2 0 3 3 2 2 Staphylococcal nuclease homologue SPX PF03105.19 CDI75022.1 - 3.8e-05 23.8 15.5 3.8e-05 23.8 15.5 2.7 2 1 0 2 2 1 1 SPX domain LptF_LptG PF03739.14 CDI75022.1 - 0.044 12.6 1.8 0.094 11.6 1.8 1.4 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG DUF2207 PF09972.9 CDI75022.1 - 0.082 11.7 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Gemini_mov PF01708.16 CDI75022.1 - 0.13 12.0 0.2 0.52 10.1 0.2 2.0 1 0 0 1 1 1 0 Geminivirus putative movement protein DDHD PF02862.17 CDI75022.1 - 0.16 12.1 16.6 2.7 8.1 0.3 3.4 3 0 0 3 3 3 0 DDHD domain EPL1 PF10513.9 CDI75022.1 - 0.17 12.2 18.3 0.61 10.4 6.4 3.5 3 0 0 3 3 3 0 Enhancer of polycomb-like BSMAP PF12280.8 CDI75022.1 - 0.35 11.1 8.7 0.18 12.0 4.9 2.3 2 0 0 2 2 2 0 Brain specific membrane anchored protein SID-1_RNA_chan PF13965.6 CDI75022.1 - 0.41 9.0 3.0 1.6 7.0 2.6 2.2 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 DUF3675 PF12428.8 CDI75022.1 - 0.42 11.2 1.5 1.1 9.8 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3675) Velvet PF11754.8 CDI75022.1 - 0.8 9.6 24.0 1.3 8.9 0.9 3.3 3 0 0 3 3 3 0 Velvet factor NPR3 PF03666.13 CDI75022.1 - 1.4 7.6 25.0 0.19 10.5 1.1 3.1 3 0 0 3 3 3 0 Nitrogen Permease regulator of amino acid transport activity 3 RAMP4 PF06624.12 CDI75022.1 - 1.7 8.7 6.7 0.71 10.0 0.1 3.3 2 1 1 3 3 3 0 Ribosome associated membrane protein RAMP4 CSG2 PF16965.5 CDI75022.1 - 2.1 7.2 9.6 0.81 8.6 3.2 2.3 2 0 0 2 2 2 0 Ceramide synthase regulator Band_3_cyto PF07565.13 CDI75022.1 - 3 7.6 14.8 4.7 6.9 5.9 3.1 3 0 0 3 3 3 0 Band 3 cytoplasmic domain Otopetrin PF03189.13 CDI75022.1 - 6.5 5.4 9.2 0.33 9.7 0.2 2.4 3 0 0 3 3 3 0 Otopetrin RskA PF10099.9 CDI75024.1 - 0.0099 16.2 6.2 0.0099 16.2 6.2 6.4 2 2 1 3 3 3 1 Anti-sigma-K factor rskA Macoilin PF09726.9 CDI75026.1 - 0.36 9.3 3.5 0.57 8.7 3.5 1.4 1 0 0 1 1 1 0 Macoilin family SR-25 PF10500.9 CDI75026.1 - 4.1 6.9 20.9 7.7 6.1 20.9 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SARAF PF06682.12 CDI75027.1 - 0.0046 16.6 9.7 0.0046 16.6 9.7 3.7 1 1 3 4 4 4 2 SOCE-associated regulatory factor of calcium homoeostasis NVEALA PF14055.6 CDI75027.1 - 3.2 7.8 5.8 31 4.7 0.5 4.3 2 1 0 2 2 2 0 NVEALA protein RskA PF10099.9 CDI75028.1 - 0.00066 20.0 11.5 0.00066 20.0 11.5 5.8 4 1 1 5 5 5 3 Anti-sigma-K factor rskA UCH PF00443.29 CDI75029.1 - 1.2e-30 106.9 0.7 1e-29 103.8 0.0 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDI75029.1 - 0.00074 19.2 10.0 0.00074 19.2 10.0 4.5 4 1 0 4 4 4 2 Ubiquitin carboxyl-terminal hydrolase DUF4746 PF15928.5 CDI75031.1 - 0.022 14.2 13.2 0.025 14.0 13.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MCM_bind PF09739.9 CDI75031.1 - 0.031 12.7 19.4 0.036 12.5 19.4 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF2828 PF11443.8 CDI75031.1 - 0.15 10.1 18.8 0.17 9.9 18.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Rtf2 PF04641.12 CDI75031.1 - 0.18 11.2 17.1 0.2 11.0 17.1 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger AP-5_subunit_s1 PF15001.6 CDI75031.1 - 0.2 11.6 20.6 0.25 11.3 20.6 1.1 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 Presenilin PF01080.17 CDI75031.1 - 0.43 9.3 26.1 0.48 9.1 26.1 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI75031.1 - 0.48 10.2 21.9 0.54 10.0 21.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 CDI75031.1 - 0.5 8.4 18.7 0.53 8.3 18.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Band_3_cyto PF07565.13 CDI75031.1 - 0.7 9.7 19.0 0.89 9.3 19.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Serinc PF03348.15 CDI75031.1 - 0.76 8.6 10.6 1 8.2 10.6 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) SLC12 PF03522.15 CDI75031.1 - 0.76 8.7 24.0 0.89 8.5 24.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Tim54 PF11711.8 CDI75031.1 - 1 8.1 20.7 1.2 7.8 20.7 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF3292 PF11696.8 CDI75031.1 - 1.1 7.6 16.3 1.2 7.4 16.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Endostatin PF06482.11 CDI75031.1 - 1.1 8.7 22.3 1.2 8.5 22.3 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CLN3 PF02487.17 CDI75031.1 - 1.1 8.2 18.4 1.3 8.0 18.4 1.1 1 0 0 1 1 1 0 CLN3 protein BORG_CEP PF14957.6 CDI75031.1 - 1.4 10.1 15.7 1.8 9.7 15.7 1.1 1 0 0 1 1 1 0 Cdc42 effector PA26 PF04636.13 CDI75031.1 - 1.9 7.3 18.6 2.2 7.1 18.6 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Myc_N PF01056.18 CDI75031.1 - 1.9 8.3 15.8 2.3 8.0 15.8 1.1 1 0 0 1 1 1 0 Myc amino-terminal region TCP PF03634.13 CDI75031.1 - 2.1 8.9 22.0 2.7 8.6 22.0 1.1 1 0 0 1 1 1 0 TCP family transcription factor WTX PF09422.10 CDI75031.1 - 2.1 7.3 14.8 2.6 7.0 14.8 1.0 1 0 0 1 1 1 0 WTX protein Mem_trans PF03547.18 CDI75031.1 - 2.2 6.6 9.5 2.4 6.5 9.5 1.0 1 0 0 1 1 1 0 Membrane transport protein ALMT PF11744.8 CDI75031.1 - 2.3 7.0 20.1 2.6 6.8 20.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CobT PF06213.12 CDI75031.1 - 2.4 7.5 28.9 3.1 7.1 28.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM60A PF15396.6 CDI75031.1 - 2.4 8.1 17.7 2.9 7.8 17.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Atg14 PF10186.9 CDI75031.1 - 2.6 7.0 26.8 2.9 6.9 26.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Velvet PF11754.8 CDI75031.1 - 2.7 7.9 20.8 3.3 7.6 20.8 1.1 1 0 0 1 1 1 0 Velvet factor CSG2 PF16965.5 CDI75031.1 - 2.8 6.8 11.4 3.7 6.4 11.4 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator SID-1_RNA_chan PF13965.6 CDI75031.1 - 2.9 6.2 12.0 3.2 6.0 12.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GBP_C PF02841.14 CDI75031.1 - 3 7.2 35.2 3.5 6.9 35.2 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain FapA PF03961.13 CDI75031.1 - 3.2 6.2 22.0 3.7 6.1 22.0 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A GREB1 PF15782.5 CDI75031.1 - 3.3 4.7 22.3 3.3 4.7 22.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer eIF-3_zeta PF05091.12 CDI75031.1 - 3.5 6.5 28.0 4.4 6.2 28.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) XRN_M PF17846.1 CDI75031.1 - 3.6 6.4 15.8 4 6.3 15.8 1.0 1 0 0 1 1 1 0 Xrn1 helical domain DUF4080 PF13311.6 CDI75031.1 - 4.6 7.4 18.1 2.9 8.1 16.2 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4080) Mgr1 PF08602.10 CDI75031.1 - 5 5.8 13.9 5.6 5.7 13.9 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit CDC45 PF02724.14 CDI75031.1 - 5.1 5.3 21.0 5.8 5.1 21.0 1.0 1 0 0 1 1 1 0 CDC45-like protein HCO3_cotransp PF00955.21 CDI75031.1 - 5.4 5.7 11.1 5.8 5.6 11.1 1.0 1 0 0 1 1 1 0 HCO3- transporter family CCSAP PF15748.5 CDI75031.1 - 6.2 6.9 29.1 7 6.7 29.1 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Radical_SAM_N PF08497.10 CDI75031.1 - 6.5 5.9 14.1 7.6 5.7 14.1 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal Lys-AminoMut_A PF09043.11 CDI75031.1 - 6.6 5.1 11.5 7.3 4.9 11.5 1.0 1 0 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit DUF3295 PF11702.8 CDI75031.1 - 7 5.9 25.1 8.2 5.7 25.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Zip PF02535.22 CDI75031.1 - 7.1 5.7 13.9 8.3 5.5 13.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Dapper PF15268.6 CDI75031.1 - 7.5 5.3 28.9 8.2 5.1 28.9 1.0 1 0 0 1 1 1 0 Dapper ABC2_membrane_2 PF12679.7 CDI75031.1 - 7.7 5.7 13.3 2.9e+02 0.5 13.3 2.0 1 1 0 1 1 1 0 ABC-2 family transporter protein PAT1 PF09770.9 CDI75031.1 - 7.7 4.6 45.7 9 4.4 45.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MMR1 PF08505.10 CDI75031.1 - 7.9 6.7 31.1 10 6.3 31.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein YjbH PF06082.11 CDI75031.1 - 8.4 5.1 17.1 9.6 4.9 17.1 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH O-antigen_lig PF13425.6 CDI75031.1 - 8.4 5.1 13.2 9.3 4.9 13.2 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF572 PF04502.13 CDI75031.1 - 8.7 5.9 22.7 10 5.6 22.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) PPL5 PF18168.1 CDI75031.1 - 8.8 5.5 14.1 11 5.2 14.1 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Peptidase_S64 PF08192.11 CDI75031.1 - 9 4.7 20.1 9.9 4.5 20.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Nop53 PF07767.11 CDI75031.1 - 9.3 5.5 31.9 11 5.3 31.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF2347 PF09804.9 CDI75031.1 - 9.9 5.6 14.1 12 5.4 14.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Pkinase PF00069.25 CDI75034.1 - 0.0014 18.1 0.0 0.2 11.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI75034.1 - 0.0087 15.4 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.6 CDI75034.1 - 0.018 15.4 3.1 0.047 14.1 0.4 2.7 2 0 0 2 2 2 0 HEAT repeats V-SNARE_C PF12352.8 CDI75035.1 - 2.5e-12 46.9 0.4 8.8e-12 45.1 0.2 2.0 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 CDI75035.1 - 0.00085 19.2 0.1 0.0025 17.7 0.0 1.8 2 0 0 2 2 2 1 Sec20 AA_permease_2 PF13520.6 CDI75035.1 - 0.037 12.9 0.4 0.048 12.5 0.4 1.1 1 0 0 1 1 1 0 Amino acid permease PriC PF07445.12 CDI75035.1 - 0.23 11.3 2.8 0.42 10.5 2.8 1.3 1 0 0 1 1 1 0 Primosomal replication protein priC Peptidase_S8 PF00082.22 CDI75036.1 - 1.4e-42 146.0 0.0 2.7e-42 145.0 0.0 1.4 1 0 0 1 1 1 1 Subtilase family Peptidase_C50 PF03568.17 CDI75036.1 - 0.00066 18.9 0.0 0.0014 17.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C50 EGF_3 PF12947.7 CDI75036.1 - 0.014 15.6 17.4 0.15 12.3 4.7 2.6 2 0 0 2 2 2 0 EGF domain Cu-binding_MopE PF11617.8 CDI75036.1 - 0.53 10.5 3.1 1.2 9.4 3.1 1.6 1 0 0 1 1 1 0 Putative metal-binding motif SF-assemblin PF06705.11 CDI75037.1 - 3.4e-29 101.9 16.4 4.2e-29 101.6 16.4 1.1 1 0 0 1 1 1 1 SF-assemblin/beta giardin Ribosomal_L17 PF01196.19 CDI75037.1 - 5.7e-12 46.4 0.9 5.7e-12 46.4 0.9 2.4 2 1 0 2 2 2 1 Ribosomal protein L17 Rab_bind PF16704.5 CDI75037.1 - 0.5 10.4 3.7 1.4 9.0 1.3 2.8 1 1 2 3 3 3 0 Rab binding domain Baculo_PEP_C PF04513.12 CDI75037.1 - 0.53 10.3 10.5 0.12 12.4 0.5 3.4 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus FBPase PF00316.20 CDI75039.1 - 7.8e-30 103.7 0.0 1.3e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Peptidase_M24 PF00557.24 CDI75040.1 - 9.9e-54 182.2 0.0 1.4e-53 181.7 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 CDI75040.1 - 1.1e-14 54.3 0.0 1.9e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain DUF3793 PF12672.7 CDI75040.1 - 0.052 13.6 0.0 0.099 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) Ank_2 PF12796.7 CDI75041.1 - 2.5e-06 28.0 0.1 3.6e-06 27.5 0.1 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI75041.1 - 0.00071 20.1 0.0 0.022 15.3 0.0 1.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI75041.1 - 0.0017 18.6 0.0 0.22 12.2 0.0 2.6 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 CDI75041.1 - 0.0071 16.8 0.0 6.2 7.5 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 CDI75041.1 - 0.03 14.6 0.0 0.086 13.2 0.0 1.8 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Peptidase_C48 PF02902.19 CDI75043.1 - 2.6e-19 69.9 0.0 6.1e-19 68.7 0.0 1.6 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain SNF2_N PF00176.23 CDI75044.1 - 3.8e-30 104.8 0.0 3.7e-28 98.3 0.0 2.2 1 1 1 2 2 2 2 SNF2 family N-terminal domain zf-RING_5 PF14634.6 CDI75044.1 - 3.1e-06 27.0 7.3 9.8e-06 25.4 7.3 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CDI75044.1 - 3.3e-05 23.7 9.5 0.0001 22.1 9.5 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDI75044.1 - 0.00017 21.3 8.4 0.00037 20.3 8.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Helicase_C PF00271.31 CDI75044.1 - 0.0004 20.7 0.0 0.025 14.9 0.0 3.0 2 1 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 CDI75044.1 - 0.0024 18.2 10.0 0.0078 16.5 10.0 2.0 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDI75044.1 - 0.0087 15.9 10.9 0.0087 15.9 10.9 2.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) UBA_4 PF14555.6 CDI75044.1 - 0.014 15.2 0.0 0.036 13.9 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain Rtf2 PF04641.12 CDI75044.1 - 0.046 13.1 0.3 0.093 12.1 0.3 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger zf-RING_UBOX PF13445.6 CDI75044.1 - 0.095 12.7 11.5 0.055 13.5 8.2 2.5 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CDI75044.1 - 0.42 10.8 12.0 1.2 9.3 12.0 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-MIZ PF02891.20 CDI75044.1 - 0.46 10.3 9.0 5.2 6.9 7.9 2.6 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Prok-RING_4 PF14447.6 CDI75044.1 - 0.57 10.1 11.1 1.6 8.6 11.1 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 CDI75044.1 - 5.3 7.0 10.0 0.37 10.7 4.2 2.2 2 0 0 2 2 1 0 zf-RING of BARD1-type protein HEAT PF02985.22 CDI75045.1 - 5.5e-07 29.3 9.6 0.011 16.0 0.1 5.2 4 0 0 4 4 4 3 HEAT repeat HEAT_2 PF13646.6 CDI75045.1 - 0.033 14.6 1.4 2.9 8.3 0.0 3.5 3 1 0 3 3 3 0 HEAT repeats HEAT_EZ PF13513.6 CDI75045.1 - 0.038 14.5 8.0 0.62 10.6 0.6 4.2 4 0 0 4 4 4 0 HEAT-like repeat V-ATPase_H_C PF11698.8 CDI75045.1 - 0.044 13.9 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 V-ATPase subunit H Histone_H2A_C PF16211.5 CDI75046.1 - 5.2e-11 42.1 0.1 9e-11 41.3 0.1 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CDI75046.1 - 2.1e-10 41.1 0.0 3.2e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 XAP5 PF04921.14 CDI75047.1 - 0.3 10.9 1.8 0.47 10.2 0.0 1.9 2 0 0 2 2 2 0 XAP5, circadian clock regulator Cullin PF00888.22 CDI75048.1 - 4.8e-119 398.7 5.9 9.6e-119 397.7 5.9 1.4 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CDI75048.1 - 3.4e-22 78.2 0.7 1.2e-21 76.5 0.4 2.2 2 0 0 2 2 2 1 Cullin protein neddylation domain DUF262 PF03235.14 CDI75049.1 - 1 9.5 7.9 0.11 12.6 1.3 2.1 1 1 0 2 2 2 0 Protein of unknown function DUF262 TFIIA PF03153.13 CDI75050.1 - 0.023 14.7 47.7 0.033 14.2 47.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI75050.1 - 0.046 12.0 32.2 0.058 11.7 32.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Macoilin PF09726.9 CDI75050.1 - 0.077 11.6 24.0 0.11 11.0 24.0 1.3 1 0 0 1 1 1 0 Macoilin family Paf1 PF03985.13 CDI75050.1 - 0.08 11.9 33.0 0.12 11.4 33.0 1.1 1 0 0 1 1 1 0 Paf1 DUF2828 PF11443.8 CDI75050.1 - 0.29 9.2 17.9 0.4 8.7 17.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) WTX PF09422.10 CDI75050.1 - 1.9 7.5 20.4 2.9 6.9 20.4 1.2 1 0 0 1 1 1 0 WTX protein Hid1 PF12722.7 CDI75050.1 - 2.3 6.3 27.9 3.2 5.8 27.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Lin-8 PF03353.15 CDI75050.1 - 8.8 5.8 34.8 14 5.2 34.8 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2722 PF10846.8 CDI75051.1 - 0.0043 16.1 23.3 0.0043 16.1 23.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Nrap_D5 PF17406.2 CDI75051.1 - 0.0061 16.3 0.7 0.0061 16.3 0.7 1.1 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 BRF1 PF07741.13 CDI75051.1 - 0.0097 16.2 2.7 0.0097 16.2 2.7 1.1 1 0 0 1 1 1 1 Brf1-like TBP-binding domain MPM1 PF17234.2 CDI75051.1 - 0.014 15.7 5.6 0.014 15.7 5.6 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 TRAP_alpha PF03896.16 CDI75051.1 - 0.017 14.3 2.5 0.021 14.1 2.5 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit ECH_1 PF00378.20 CDI75051.1 - 0.019 14.3 2.9 0.02 14.2 2.9 1.1 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase MetallophosC PF16370.5 CDI75051.1 - 0.02 15.1 0.2 0.024 14.9 0.2 1.0 1 0 0 1 1 1 0 C terminal of Calcineurin-like phosphoesterase SpoIIP PF07454.11 CDI75051.1 - 0.023 14.2 5.0 0.019 14.4 5.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF2076 PF09849.9 CDI75051.1 - 0.029 14.4 20.3 0.033 14.2 20.3 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) TFIIA PF03153.13 CDI75051.1 - 0.047 13.7 25.2 0.042 13.8 25.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EIIBC-GUT_N PF03612.14 CDI75051.1 - 0.053 13.3 7.0 0.057 13.2 7.0 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Flavodoxin_NdrI PF07972.11 CDI75051.1 - 0.055 13.6 2.2 0.069 13.3 2.2 1.2 1 0 0 1 1 1 0 NrdI Flavodoxin like Hydin_ADK PF17213.3 CDI75051.1 - 0.093 13.0 7.1 0.11 12.8 7.1 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain TMEM51 PF15345.6 CDI75051.1 - 0.093 12.6 9.8 0.089 12.6 9.8 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 DUF775 PF05603.12 CDI75051.1 - 0.11 12.1 9.5 0.11 12.0 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) RNA_pol_Rbc25 PF08292.12 CDI75051.1 - 0.11 12.8 8.0 0.13 12.5 8.0 1.1 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 DDHD PF02862.17 CDI75051.1 - 0.11 12.6 4.3 0.1 12.7 4.3 1.0 1 0 0 1 1 1 0 DDHD domain V_ATPase_I PF01496.19 CDI75051.1 - 0.11 10.4 5.6 0.098 10.6 5.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Suf PF05843.14 CDI75051.1 - 0.13 12.2 12.6 0.13 12.3 12.6 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) UPF0524 PF15823.5 CDI75051.1 - 0.14 11.5 4.2 0.13 11.7 4.2 1.1 1 0 0 1 1 1 0 UPF0524 of C3orf70 EPL1 PF10513.9 CDI75051.1 - 0.15 12.4 7.8 0.15 12.5 7.8 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like Peptidase_S49_N PF08496.10 CDI75051.1 - 0.18 11.9 9.2 0.23 11.5 9.2 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Band_3_cyto PF07565.13 CDI75051.1 - 0.19 11.5 5.1 0.16 11.7 5.1 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CLN3 PF02487.17 CDI75051.1 - 0.3 10.1 2.9 0.25 10.3 2.9 1.1 1 0 0 1 1 1 0 CLN3 protein Mss4 PF04421.13 CDI75051.1 - 0.3 11.2 3.1 0.36 11.0 3.1 1.1 1 0 0 1 1 1 0 Mss4 protein ALMT PF11744.8 CDI75051.1 - 0.33 9.8 2.3 0.28 10.0 2.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter OATP PF03137.20 CDI75051.1 - 0.39 8.9 3.0 0.34 9.1 3.0 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family FHIPEP PF00771.20 CDI75051.1 - 0.47 8.8 5.1 0.43 9.0 5.1 1.0 1 0 0 1 1 1 0 FHIPEP family USP8_interact PF08941.10 CDI75051.1 - 0.57 10.0 9.2 0.5 10.2 9.2 1.1 1 0 0 1 1 1 0 USP8 interacting Neur_chan_memb PF02932.16 CDI75051.1 - 0.58 10.2 3.6 0.5 10.4 3.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.10 CDI75051.1 - 0.59 8.7 6.0 0.54 8.9 6.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Med15 PF09606.10 CDI75051.1 - 0.67 8.6 27.5 0.61 8.7 27.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal UPF0560 PF10577.9 CDI75051.1 - 0.88 8.0 14.6 0.77 8.2 14.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PepSY_TM PF03929.16 CDI75051.1 - 0.9 9.1 5.8 0.88 9.2 5.8 1.0 1 0 0 1 1 1 0 PepSY-associated TM region Presenilin PF01080.17 CDI75051.1 - 0.98 8.1 9.9 1.1 7.9 9.9 1.0 1 0 0 1 1 1 0 Presenilin DUF4199 PF13858.6 CDI75051.1 - 1.7 9.0 4.7 1.6 9.1 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Connexin PF00029.19 CDI75051.1 - 3 7.5 7.1 3.2 7.4 7.1 1.1 1 0 0 1 1 1 0 Connexin DUF4834 PF16118.5 CDI75051.1 - 3.4 8.7 15.1 4.2 8.4 15.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Sec62 PF03839.16 CDI75051.1 - 5.6 6.4 7.4 6.1 6.3 7.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DUF3464 PF11947.8 CDI75051.1 - 5.9 6.6 11.8 7.5 6.3 11.8 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Orf78 PF06024.12 CDI75051.1 - 6.6 7.1 8.7 8 6.8 8.7 1.1 1 0 0 1 1 1 0 Orf78 (ac78) MecA PF05389.12 CDI75051.1 - 6.7 6.3 11.3 7.5 6.1 11.3 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) HA2 PF04408.23 CDI75051.1 - 7 7.0 6.8 7.8 6.8 6.8 1.1 1 0 0 1 1 1 0 Helicase associated domain (HA2) EphA2_TM PF14575.6 CDI75051.1 - 7.2 7.6 7.6 11 6.9 7.6 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CobT PF06213.12 CDI75051.1 - 7.3 5.9 17.6 8.4 5.7 17.6 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3499 PF12005.8 CDI75051.1 - 8 7.1 8.2 11 6.7 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3499) Spt20 PF12090.8 CDI75051.1 - 8.5 5.9 40.7 9.2 5.8 40.7 1.1 1 0 0 1 1 1 0 Spt20 family SARAF PF06682.12 CDI75052.1 - 0.0028 17.4 1.2 0.0043 16.7 1.2 1.3 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis eIF-3_zeta PF05091.12 CDI75052.1 - 0.0038 16.3 4.7 0.0036 16.4 4.7 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM209 PF15206.6 CDI75052.1 - 0.014 15.2 2.3 0.02 14.7 2.3 1.4 1 0 0 1 1 1 0 FAM209 family Presenilin PF01080.17 CDI75052.1 - 0.014 14.2 2.0 0.015 14.1 2.0 1.3 1 0 0 1 1 1 0 Presenilin Cadherin_C_2 PF16492.5 CDI75052.1 - 0.021 15.6 0.5 0.021 15.6 0.5 1.7 2 0 0 2 2 1 0 Cadherin cytoplasmic C-terminal GRP PF07172.11 CDI75052.1 - 0.036 14.7 2.3 0.036 14.7 2.3 2.1 1 1 1 2 2 2 0 Glycine rich protein family EphA2_TM PF14575.6 CDI75052.1 - 0.038 14.9 5.5 0.038 14.9 5.5 2.4 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain FAM176 PF14851.6 CDI75052.1 - 0.052 13.2 1.1 0.12 12.1 1.1 1.5 1 0 0 1 1 1 0 FAM176 family Conotoxin PF02950.17 CDI75052.1 - 0.063 14.3 6.1 0.063 14.3 6.1 2.8 1 1 1 2 2 2 0 Conotoxin O-antigen_lig PF13425.6 CDI75052.1 - 0.085 11.6 0.4 0.11 11.2 0.4 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Neur_chan_memb PF02932.16 CDI75052.1 - 0.11 12.5 3.3 0.14 12.2 3.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MscL PF01741.18 CDI75052.1 - 0.14 12.5 0.5 0.19 12.0 0.5 1.3 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL DUF572 PF04502.13 CDI75052.1 - 0.14 11.7 6.4 0.17 11.4 6.4 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF572) Tau95_N PF17682.1 CDI75052.1 - 0.17 12.1 4.2 0.49 10.6 4.3 1.5 1 1 0 1 1 1 0 Tau95 Triple barrel domain OATP PF03137.20 CDI75052.1 - 0.44 8.8 1.6 0.68 8.1 1.6 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4407 PF14362.6 CDI75052.1 - 0.58 9.4 17.7 0.77 9.0 17.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Dpy19 PF10034.9 CDI75052.1 - 0.61 8.2 8.0 0.81 7.8 8.0 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation V_ATPase_I PF01496.19 CDI75052.1 - 0.74 7.7 12.1 0.87 7.4 12.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PigN PF04987.14 CDI75052.1 - 1.2 7.9 9.5 0.066 12.1 4.6 1.4 2 0 0 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) OPA3 PF07047.12 CDI75052.1 - 1.4 8.8 8.2 0.55 10.0 5.0 1.9 1 1 1 2 2 2 0 Optic atrophy 3 protein (OPA3) DUF5531 PF17671.1 CDI75052.1 - 1.4 8.8 6.4 0.28 11.1 1.9 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5531) Med15 PF09606.10 CDI75052.1 - 2.5 6.7 39.2 3.2 6.3 39.2 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal WBP-1 PF11669.8 CDI75052.1 - 4.6 7.9 8.8 2.8 8.6 6.2 1.8 1 1 1 2 2 2 0 WW domain-binding protein 1 NPL PF17800.1 CDI75052.1 - 5.4 7.6 7.4 0.55 10.8 0.1 2.1 2 0 0 2 2 2 0 Nucleoplasmin-like domain DUF1180 PF06679.12 CDI75052.1 - 6 7.2 19.1 1.1 9.6 3.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1180) DUF3464 PF11947.8 CDI75052.1 - 6.1 6.6 8.9 0.55 10.0 4.4 1.6 2 0 0 2 2 1 0 Photosynthesis affected mutant 68 Ctr PF04145.15 CDI75052.1 - 7.4 7.2 6.3 11 6.7 6.3 1.6 1 1 0 1 1 1 0 Ctr copper transporter family FGF-BP1 PF06473.12 CDI75052.1 - 7.8 6.3 17.1 0.46 10.3 10.8 1.9 1 1 1 2 2 2 0 FGF binding protein 1 (FGF-BP1) Spt20 PF12090.8 CDI75053.1 - 0.012 15.2 30.0 0.015 14.9 30.0 1.3 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI75053.1 - 0.044 13.8 29.7 0.049 13.6 29.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 CDI75053.1 - 0.23 10.5 9.4 0.26 10.3 9.4 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Androgen_recep PF02166.16 CDI75053.1 - 0.42 9.4 19.0 0.54 9.1 19.0 1.2 1 0 0 1 1 1 0 Androgen receptor UPF0524 PF15823.5 CDI75053.1 - 3.8 6.9 17.7 1.7 8.0 15.7 1.5 1 1 0 1 1 1 0 UPF0524 of C3orf70 PAT1 PF09770.9 CDI75053.1 - 4.3 5.5 23.5 5.1 5.2 23.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4407 PF14362.6 CDI75053.1 - 4.9 6.4 8.4 5.7 6.2 8.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mem_trans PF03547.18 CDI75053.1 - 5.3 5.3 16.1 6.9 4.9 16.1 1.2 1 0 0 1 1 1 0 Membrane transport protein MAT1 PF06391.13 CDI75053.1 - 6.1 6.6 16.1 7.8 6.3 16.1 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Spt20 PF12090.8 CDI75055.1 - 0.0047 16.6 21.0 0.0047 16.6 21.0 7.1 7 1 1 8 8 8 5 Spt20 family RskA PF10099.9 CDI75055.1 - 0.0082 16.5 15.2 0.0082 16.5 15.2 8.9 2 2 2 4 4 4 2 Anti-sigma-K factor rskA DUF755 PF05501.11 CDI75055.1 - 0.0086 16.3 27.7 0.0086 16.3 27.7 8.4 7 2 1 9 9 9 3 Domain of unknown function (DUF755) AP3D1 PF06375.11 CDI75055.1 - 0.029 14.6 0.6 0.029 14.6 0.6 7.5 5 1 2 8 8 8 0 AP-3 complex subunit delta-1 Sin_N PF04801.13 CDI75056.1 - 0.0071 15.6 16.2 0.0079 15.5 16.2 1.1 1 0 0 1 1 1 1 Sin-like protein conserved region Lin-8 PF03353.15 CDI75056.1 - 0.082 12.5 13.6 0.1 12.1 13.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MAT1 PF06391.13 CDI75056.1 - 0.24 11.2 17.4 0.34 10.7 17.4 1.3 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 TFIIA PF03153.13 CDI75056.1 - 0.6 10.0 29.3 0.77 9.7 29.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_S64 PF08192.11 CDI75056.1 - 0.69 8.3 15.9 0.8 8.1 15.9 1.0 1 0 0 1 1 1 0 Peptidase family S64 GREB1 PF15782.5 CDI75056.1 - 1.3 6.1 18.1 1.5 5.8 18.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Borrelia_P83 PF05262.11 CDI75056.1 - 2.3 6.6 15.2 2.5 6.5 15.2 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein V_ATPase_I PF01496.19 CDI75056.1 - 3.4 5.5 11.6 3.6 5.4 11.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1645 PF07816.11 CDI75056.1 - 3.7 8.1 18.7 15 6.1 18.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1645) Endonuc_Holl PF10107.9 CDI75056.1 - 5.1 6.9 9.6 6.4 6.6 9.6 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Membralin PF09746.9 CDI75056.1 - 8.4 5.3 9.0 9.3 5.2 9.0 1.2 1 0 0 1 1 1 0 Tumour-associated protein DUF3391 PF11871.8 CDI75058.1 - 0.0042 17.6 4.4 0.0042 17.6 4.4 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3391) PH PF00169.29 CDI75058.1 - 0.038 14.5 0.0 0.071 13.6 0.0 1.4 1 0 0 1 1 1 0 PH domain RraA-like PF03737.15 CDI75058.1 - 0.1 12.7 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Aldolase/RraA PH_9 PF15410.6 CDI75058.1 - 0.11 12.9 0.0 0.11 12.9 0.0 2.6 3 0 0 3 3 3 0 Pleckstrin homology domain Presenilin PF01080.17 CDI75058.1 - 1.1 7.9 16.3 0.17 10.6 11.9 1.7 2 0 0 2 2 2 0 Presenilin Neur_chan_memb PF02932.16 CDI75058.1 - 1.4 8.9 10.7 3.1 7.8 10.7 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF5327 PF17261.2 CDI75058.1 - 6.8 7.5 26.9 0.39 11.5 15.3 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5327) CRT10 PF08728.10 CDI75058.1 - 8.2 4.5 6.9 11 4.0 6.9 1.1 1 0 0 1 1 1 0 CRT10 Eapp_C PF10238.9 CDI75059.1 - 0.0035 17.4 1.9 0.0035 17.4 1.9 3.6 2 1 0 2 2 2 1 E2F-associated phosphoprotein DUF4770 PF15994.5 CDI75059.1 - 0.017 15.4 3.5 0.017 15.4 3.5 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4770) Orf78 PF06024.12 CDI75059.1 - 0.097 13.0 0.5 0.097 13.0 0.5 4.0 3 2 0 3 3 3 0 Orf78 (ac78) Yos1 PF08571.10 CDI75059.1 - 0.88 9.9 0.0 0.88 9.9 0.0 2.5 2 1 0 2 2 2 0 Yos1-like CrgA PF06781.12 CDI75059.1 - 1.3 9.1 0.0 1.3 9.1 0.0 4.0 3 2 0 3 3 3 0 Cell division protein CrgA TT_ORF1 PF02956.14 CDI75059.1 - 1.3 7.6 17.5 1.6 7.3 1.3 2.1 2 0 0 2 2 2 0 TT viral orf 1 EIF4E-T PF10477.9 CDI75059.1 - 1.6 7.4 32.9 0.053 12.4 4.0 2.2 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E eIF-3_zeta PF05091.12 CDI75059.1 - 5.1 5.9 43.0 0.12 11.3 8.9 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI75061.1 - 5.7 5.6 29.6 7.4 5.2 29.6 1.1 1 0 0 1 1 1 0 Presenilin zf-C2H2_3rep PF18868.1 CDI75061.1 - 8.6 7.0 16.7 1.2 9.8 2.0 2.1 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats RskA PF10099.9 CDI75062.1 - 0.0028 18.0 8.2 0.0028 18.0 8.2 19.0 4 4 9 14 14 14 4 Anti-sigma-K factor rskA NAD_binding_8 PF13450.6 CDI75064.1 - 1.5e-08 34.7 3.1 2.8e-07 30.7 3.1 3.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CDI75064.1 - 0.00035 21.1 2.5 0.00076 20.0 2.5 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DUF2828 PF11443.8 CDI75064.1 - 0.00042 18.6 5.9 0.00042 18.6 5.9 5.7 4 1 1 5 5 5 1 Domain of unknown function (DUF2828) UPF0564 PF10595.9 CDI75064.1 - 0.0012 18.0 15.4 0.0012 18.0 15.4 7.2 6 2 0 6 6 6 2 Uncharacterised protein family UPF0564 Thi4 PF01946.17 CDI75064.1 - 0.19 10.9 2.3 0.44 9.7 2.3 1.5 1 0 0 1 1 1 0 Thi4 family hDGE_amylase PF14701.6 CDI75065.1 - 3.9e-12 46.0 0.0 3e-11 43.1 0.0 2.2 2 1 0 2 2 2 1 Glycogen debranching enzyme, glucanotransferase domain DUF2722 PF10846.8 CDI75065.1 - 0.00099 18.2 2.2 0.00099 18.2 2.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI75065.1 - 0.0035 17.4 2.8 0.0038 17.3 2.8 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI75065.1 - 0.32 10.6 12.4 0.44 10.1 12.4 1.2 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 CDI75065.1 - 0.54 9.3 3.6 0.82 8.7 3.6 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Sin_N PF04801.13 CDI75065.1 - 0.93 8.6 7.4 1.5 8.0 7.4 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region Androgen_recep PF02166.16 CDI75065.1 - 4.3 6.1 24.6 1.3 7.8 10.8 2.2 2 0 0 2 2 2 0 Androgen receptor Connexin PF00029.19 CDI75066.1 - 0.011 15.5 10.0 0.012 15.4 10.0 1.1 1 0 0 1 1 1 0 Connexin ATP11 PF06644.11 CDI75066.1 - 0.012 15.5 17.4 0.013 15.3 17.4 1.0 1 0 0 1 1 1 0 ATP11 protein Pex14_N PF04695.13 CDI75066.1 - 0.016 15.9 22.7 0.019 15.7 22.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MecA PF05389.12 CDI75066.1 - 0.019 14.6 13.0 0.021 14.5 13.0 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) FAM60A PF15396.6 CDI75066.1 - 0.024 14.7 14.0 0.028 14.4 14.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A FAM176 PF14851.6 CDI75066.1 - 0.033 13.8 8.6 0.039 13.6 8.6 1.2 1 0 0 1 1 1 0 FAM176 family RR_TM4-6 PF06459.12 CDI75066.1 - 0.04 13.7 16.1 0.046 13.6 16.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Mgr1 PF08602.10 CDI75066.1 - 0.041 12.7 4.7 0.043 12.7 4.7 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit CobT PF06213.12 CDI75066.1 - 0.052 12.9 26.1 0.06 12.7 26.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3408 PF11888.8 CDI75066.1 - 0.054 13.6 16.8 0.066 13.3 16.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) CPSF100_C PF13299.6 CDI75066.1 - 0.071 13.3 12.3 0.084 13.1 12.3 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal ADP_ribosyl_GH PF03747.14 CDI75066.1 - 0.095 12.4 1.0 0.11 12.2 1.0 1.0 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase CDC45 PF02724.14 CDI75066.1 - 0.099 10.9 11.7 0.11 10.8 11.7 1.0 1 0 0 1 1 1 0 CDC45-like protein RPN2_C PF18004.1 CDI75066.1 - 0.14 12.1 14.8 0.17 11.8 14.8 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF913 PF06025.12 CDI75066.1 - 0.14 11.1 10.6 0.16 11.0 10.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) HA2 PF04408.23 CDI75066.1 - 0.16 12.3 10.5 0.2 12.0 10.5 1.2 1 0 0 1 1 1 0 Helicase associated domain (HA2) DUF572 PF04502.13 CDI75066.1 - 0.19 11.3 15.5 0.2 11.2 15.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) SPG4 PF17325.2 CDI75066.1 - 0.24 12.5 10.9 0.32 12.1 10.9 1.3 1 0 0 1 1 1 0 Stationary phase protein 4 Dynactin_p62 PF05502.13 CDI75066.1 - 0.26 10.0 15.0 0.3 9.8 15.0 1.0 1 0 0 1 1 1 0 Dynactin p62 family Ctr PF04145.15 CDI75066.1 - 0.31 11.6 10.1 0.35 11.5 10.1 1.1 1 0 0 1 1 1 0 Ctr copper transporter family SUFU_C PF12470.8 CDI75066.1 - 0.36 10.9 12.5 0.55 10.2 12.5 1.3 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain ALMT PF11744.8 CDI75066.1 - 0.36 9.6 17.7 0.42 9.4 17.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter eIF-3_zeta PF05091.12 CDI75066.1 - 0.37 9.7 21.5 0.42 9.5 21.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Serinc PF03348.15 CDI75066.1 - 0.42 9.5 10.6 0.45 9.4 10.6 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Zip PF02535.22 CDI75066.1 - 0.48 9.6 8.0 0.47 9.6 8.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Cytochrom_NNT PF03264.14 CDI75066.1 - 0.49 10.1 12.8 0.67 9.6 12.8 1.1 1 0 0 1 1 1 0 NapC/NirT cytochrome c family, N-terminal region FHIPEP PF00771.20 CDI75066.1 - 0.51 8.7 9.8 0.61 8.5 9.8 1.2 1 0 0 1 1 1 0 FHIPEP family DDRGK PF09756.9 CDI75066.1 - 0.53 9.8 25.1 0.65 9.6 25.1 1.1 1 0 0 1 1 1 0 DDRGK domain Folate_carrier PF01770.18 CDI75066.1 - 0.56 8.9 10.6 0.64 8.7 10.6 1.1 1 0 0 1 1 1 0 Reduced folate carrier DUF2370 PF10176.9 CDI75066.1 - 0.6 9.7 8.0 0.72 9.5 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) CLN3 PF02487.17 CDI75066.1 - 0.6 9.1 13.2 0.6 9.1 13.2 1.1 1 0 0 1 1 1 0 CLN3 protein Usp PF00582.26 CDI75066.1 - 0.61 10.6 4.9 0.76 10.3 4.9 1.1 1 0 0 1 1 1 0 Universal stress protein family FAM91_C PF14648.6 CDI75066.1 - 0.61 8.8 11.8 0.69 8.7 11.8 1.0 1 0 0 1 1 1 0 FAM91 C-terminus Rtf2 PF04641.12 CDI75066.1 - 0.62 9.4 16.2 0.68 9.3 16.2 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger SAE2 PF08573.10 CDI75066.1 - 0.63 11.2 18.6 0.81 10.8 18.6 1.1 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus TFB6 PF17110.5 CDI75066.1 - 0.63 9.8 10.5 0.72 9.6 10.5 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Tim54 PF11711.8 CDI75066.1 - 0.65 8.7 15.0 0.72 8.6 15.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FPN1 PF06963.12 CDI75066.1 - 0.66 8.5 9.2 0.76 8.3 9.2 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) MMU163 PF17119.5 CDI75066.1 - 0.69 9.0 7.4 0.74 8.9 7.4 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Ureide_permease PF07168.11 CDI75066.1 - 0.72 8.5 8.7 0.82 8.4 8.7 1.1 1 0 0 1 1 1 0 Ureide permease TMEM144 PF07857.12 CDI75066.1 - 0.78 8.6 2.1 0.77 8.7 2.1 1.1 1 0 0 1 1 1 0 Transmembrane family, TMEM144 of transporters PA26 PF04636.13 CDI75066.1 - 0.82 8.5 16.0 0.94 8.3 16.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Presenilin PF01080.17 CDI75066.1 - 0.83 8.4 22.2 0.91 8.2 22.2 1.0 1 0 0 1 1 1 0 Presenilin CCDC53 PF10152.9 CDI75066.1 - 0.83 10.1 18.8 1.1 9.7 18.8 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex CSG2 PF16965.5 CDI75066.1 - 0.86 8.5 11.4 0.9 8.4 11.4 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator PPL5 PF18168.1 CDI75066.1 - 0.87 8.8 12.2 0.94 8.7 12.2 1.1 1 0 0 1 1 1 0 Prim-pol family 5 U1snRNP70_N PF12220.8 CDI75066.1 - 0.88 10.2 18.8 1.2 9.8 18.8 1.2 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Peptidase_S49_N PF08496.10 CDI75066.1 - 0.91 9.6 17.1 1.1 9.3 17.1 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal TFIIA PF03153.13 CDI75066.1 - 0.94 9.4 46.8 0.97 9.4 46.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 CDI75066.1 - 0.98 7.3 19.8 1.1 7.0 19.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Lin-8 PF03353.15 CDI75066.1 - 0.99 8.9 23.1 1.1 8.7 23.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist EOS1 PF12326.8 CDI75066.1 - 1 9.3 9.9 1.2 9.1 9.9 1.1 1 0 0 1 1 1 0 N-glycosylation protein PIP5K PF01504.18 CDI75066.1 - 1.1 8.5 13.3 1.2 8.3 13.3 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase TERB2 PF15101.6 CDI75066.1 - 1.1 9.3 24.1 1.3 9.0 24.1 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SelP_N PF04592.14 CDI75066.1 - 1.1 8.6 17.0 1.4 8.3 17.0 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF1764 PF08576.10 CDI75066.1 - 1.2 10.1 16.8 1.8 9.5 16.8 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF2828 PF11443.8 CDI75066.1 - 1.2 7.1 17.0 1.4 7.0 17.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) KAsynt_C_assoc PF16197.5 CDI75066.1 - 1.2 9.6 9.0 2.2 8.7 9.0 1.5 1 1 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension DUF5327 PF17261.2 CDI75066.1 - 1.2 9.9 28.0 1.5 9.6 28.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5327) SID-1_RNA_chan PF13965.6 CDI75066.1 - 1.3 7.4 9.1 1.4 7.3 9.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 MCU PF04678.13 CDI75066.1 - 1.5 8.9 13.3 1.6 8.8 13.3 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF868 PF05910.12 CDI75066.1 - 1.6 8.3 11.5 1.9 8.0 11.5 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF868) CCSAP PF15748.5 CDI75066.1 - 1.6 8.9 21.1 1.8 8.7 21.1 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Cellulose_synt PF03552.14 CDI75066.1 - 1.6 7.1 9.3 1.7 7.0 9.3 1.0 1 0 0 1 1 1 0 Cellulose synthase DUF1980 PF09323.10 CDI75066.1 - 1.6 8.6 12.5 2 8.3 12.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) PigN PF04987.14 CDI75066.1 - 1.7 7.4 8.7 1.8 7.3 8.7 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) MDM31_MDM32 PF08118.11 CDI75066.1 - 1.7 7.2 14.2 1.8 7.2 14.2 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF2347 PF09804.9 CDI75066.1 - 1.9 8.0 11.6 2 7.9 11.6 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) PGA_cap PF09587.10 CDI75066.1 - 2 7.8 6.8 2.4 7.6 6.8 1.1 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap NEMP PF10225.9 CDI75066.1 - 2.1 7.9 9.8 2.4 7.8 9.8 1.1 1 0 0 1 1 1 0 NEMP family DUF2072 PF09845.9 CDI75066.1 - 2.2 8.5 13.1 3.3 8.0 13.1 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein DDHD PF02862.17 CDI75066.1 - 2.3 8.3 20.0 2.6 8.1 20.0 1.1 1 0 0 1 1 1 0 DDHD domain Mcm10 PF09332.11 CDI75066.1 - 2.3 7.5 23.3 2.6 7.4 23.3 1.0 1 0 0 1 1 1 0 Mcm10 replication factor MMR1 PF08505.10 CDI75066.1 - 2.4 8.4 24.2 2.9 8.1 24.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Pal1 PF08316.11 CDI75066.1 - 2.4 8.9 10.0 2.8 8.7 10.0 1.2 1 0 0 1 1 1 0 Pal1 cell morphology protein SpoIIP PF07454.11 CDI75066.1 - 2.4 7.5 22.6 2.9 7.3 22.6 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4192 PF13830.6 CDI75066.1 - 2.8 7.9 7.3 3.4 7.7 7.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) TCP PF03634.13 CDI75066.1 - 2.8 8.5 20.1 3.3 8.2 20.1 1.1 1 0 0 1 1 1 0 TCP family transcription factor EPL1 PF10513.9 CDI75066.1 - 2.8 8.3 19.6 3.9 7.9 19.6 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like BORG_CEP PF14957.6 CDI75066.1 - 2.9 9.1 13.0 3.4 8.9 13.0 1.2 1 0 0 1 1 1 0 Cdc42 effector SLC12 PF03522.15 CDI75066.1 - 3 6.7 19.7 3.3 6.6 19.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Baculo_PP31 PF05311.11 CDI75066.1 - 3.1 7.2 16.5 3.6 7.0 16.5 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF3112 PF11309.8 CDI75066.1 - 3.3 7.1 4.9 3.7 6.9 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Afi1 PF07792.12 CDI75066.1 - 3.3 8.2 18.5 4.1 7.9 18.5 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking HCO3_cotransp PF00955.21 CDI75066.1 - 3.3 6.4 10.8 3.6 6.3 10.8 1.0 1 0 0 1 1 1 0 HCO3- transporter family TMEM174 PF15029.6 CDI75066.1 - 3.4 7.3 10.3 3.9 7.1 10.3 1.1 1 0 0 1 1 1 0 Transmembrane protein 174 RPA43_OB PF17875.1 CDI75066.1 - 3.7 8.2 12.6 5 7.8 12.6 1.3 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I eIF3_subunit PF08597.10 CDI75066.1 - 3.9 7.3 21.9 5.4 6.8 21.9 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit FixO PF02433.15 CDI75066.1 - 4.1 6.8 11.5 4.6 6.6 11.5 1.1 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO Scs3p PF10261.9 CDI75066.1 - 4.1 6.8 7.1 4.4 6.7 7.1 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF2126 PF09899.9 CDI75066.1 - 4.4 5.3 13.1 4.7 5.2 13.1 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) PAT1 PF09770.9 CDI75066.1 - 5.1 5.2 31.6 5.5 5.1 31.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Velvet PF11754.8 CDI75066.1 - 5.1 7.0 18.7 5.8 6.8 18.7 1.0 1 0 0 1 1 1 0 Velvet factor Membralin PF09746.9 CDI75066.1 - 5.3 6.0 13.4 5.5 5.9 13.4 1.0 1 0 0 1 1 1 0 Tumour-associated protein Neur_chan_memb PF02932.16 CDI75066.1 - 5.4 7.0 15.2 6.2 6.8 15.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.10 CDI75066.1 - 5.8 5.5 16.7 6.3 5.4 16.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GNAT_acetyltr_2 PF13718.6 CDI75066.1 - 6 6.2 13.9 7.3 5.9 13.9 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Peptidase_S15 PF02129.18 CDI75066.1 - 6.2 6.3 12.3 7.1 6.1 12.3 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Band_3_cyto PF07565.13 CDI75066.1 - 6.3 6.5 19.2 7 6.4 19.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Folliculin PF11704.8 CDI75066.1 - 6.5 6.6 16.1 7.6 6.4 16.1 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport MDM10 PF12519.8 CDI75066.1 - 6.5 5.5 15.6 7.1 5.4 15.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DNApol_Exo PF18136.1 CDI75066.1 - 6.5 5.8 15.6 7.3 5.6 15.6 1.2 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain Peptidase_U57 PF05582.12 CDI75066.1 - 6.8 5.9 13.7 8 5.6 13.7 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Paf1 PF03985.13 CDI75066.1 - 7 5.5 24.6 8 5.3 24.6 1.0 1 0 0 1 1 1 0 Paf1 CAF1 PF04857.20 CDI75066.1 - 7 5.7 13.7 7.7 5.6 13.7 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease Hid1 PF12722.7 CDI75066.1 - 7 4.6 18.9 7.2 4.6 18.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein YABBY PF04690.13 CDI75066.1 - 7.2 7.2 17.1 9.1 6.8 17.1 1.1 1 0 0 1 1 1 0 YABBY protein AIF_C PF14721.6 CDI75066.1 - 7.5 6.9 18.7 9.7 6.6 18.7 1.4 1 1 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term HemX PF04375.14 CDI75066.1 - 9.7 5.4 42.0 12 5.1 42.0 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase RhoGEF PF00621.20 CDI75067.1 - 0.03 14.5 1.0 0.086 13.1 1.0 1.7 1 0 0 1 1 1 0 RhoGEF domain Mucin-like PF16058.5 CDI75068.1 - 0.25 11.5 53.9 2.9 8.0 20.8 2.3 1 1 1 2 2 2 0 Mucin-like ATP-synt_B PF00430.18 CDI75068.1 - 2.5 8.2 11.7 1.1 9.4 8.2 2.0 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) SR-25 PF10500.9 CDI75069.1 - 4.1e-05 23.3 28.9 0.0002 21.1 6.8 10.5 10 1 1 11 11 11 6 Nuclear RNA-splicing-associated protein BUD22 PF09073.10 CDI75069.1 - 0.00011 21.8 10.1 0.00011 21.8 10.1 6.1 2 2 2 4 4 4 3 BUD22 HupF_HypC PF01455.18 CDI75069.1 - 0.048 13.8 0.0 0.17 12.0 0.0 2.0 1 0 0 1 1 1 0 HupF/HypC family DUF2048 PF09752.9 CDI75070.1 - 3.9 6.5 14.3 0.068 12.3 1.9 2.5 2 0 0 2 2 2 0 Abhydrolase domain containing 18 RskA PF10099.9 CDI75071.1 - 0.018 15.3 11.4 0.018 15.3 11.4 8.5 3 2 4 8 8 8 0 Anti-sigma-K factor rskA Mucin PF01456.17 CDI75071.1 - 0.02 14.9 0.6 0.02 14.9 0.6 6.8 6 2 1 7 7 7 0 Mucin-like glycoprotein FAM176 PF14851.6 CDI75072.1 - 0.00025 20.7 3.6 0.00029 20.5 3.6 1.1 1 0 0 1 1 1 1 FAM176 family DivIC PF04977.15 CDI75072.1 - 0.0023 17.6 12.6 0.0038 17.0 12.6 1.3 1 0 0 1 1 1 1 Septum formation initiator HemX PF04375.14 CDI75072.1 - 0.004 16.5 7.7 0.004 16.5 7.7 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase TRAP_alpha PF03896.16 CDI75072.1 - 0.006 15.8 2.6 0.0068 15.7 2.6 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Nucleoside_tran PF01733.18 CDI75072.1 - 0.0082 15.6 3.2 0.008 15.6 3.2 1.0 1 0 0 1 1 1 1 Nucleoside transporter RskA PF10099.9 CDI75072.1 - 0.013 15.8 1.3 0.014 15.7 1.3 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI75072.1 - 0.013 16.4 3.9 0.018 16.0 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Connexin PF00029.19 CDI75072.1 - 0.019 14.7 3.0 0.02 14.7 3.0 1.1 1 0 0 1 1 1 0 Connexin Androgen_recep PF02166.16 CDI75072.1 - 0.02 13.8 11.3 0.024 13.5 11.3 1.0 1 0 0 1 1 1 0 Androgen receptor SLC12 PF03522.15 CDI75072.1 - 0.027 13.5 4.3 0.027 13.5 4.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4079 PF13301.6 CDI75072.1 - 0.03 14.5 0.1 0.032 14.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) CBP_BcsG PF11658.8 CDI75072.1 - 0.031 12.7 2.3 0.033 12.6 2.3 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Presenilin PF01080.17 CDI75072.1 - 0.034 12.9 2.1 0.036 12.9 2.1 1.2 1 0 0 1 1 1 0 Presenilin FHIPEP PF00771.20 CDI75072.1 - 0.049 12.1 1.8 0.046 12.2 1.8 1.0 1 0 0 1 1 1 0 FHIPEP family EphA2_TM PF14575.6 CDI75072.1 - 0.053 14.4 2.8 0.079 13.8 2.8 1.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Protocadherin PF08374.11 CDI75072.1 - 0.066 13.2 2.2 0.068 13.1 2.2 1.0 1 0 0 1 1 1 0 Protocadherin G0-G1_switch_2 PF15103.6 CDI75072.1 - 0.093 13.2 6.1 0.12 12.9 6.1 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 ExbD PF02472.16 CDI75072.1 - 0.1 12.8 3.2 0.14 12.4 3.2 1.3 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR TMEM51 PF15345.6 CDI75072.1 - 0.1 12.4 6.2 0.12 12.2 6.2 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Ctr PF04145.15 CDI75072.1 - 0.11 13.1 1.1 0.11 13.1 1.1 1.1 1 0 0 1 1 1 0 Ctr copper transporter family DcuA_DcuB PF03605.14 CDI75072.1 - 0.12 11.3 0.9 0.11 11.4 0.9 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF3357 PF11837.8 CDI75072.1 - 0.12 12.8 1.2 0.18 12.2 0.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) Conotoxin PF02950.17 CDI75072.1 - 0.13 13.3 8.3 0.83 10.7 8.3 2.2 1 1 0 1 1 1 0 Conotoxin Sec62 PF03839.16 CDI75072.1 - 0.13 11.7 2.8 0.14 11.6 2.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 CLN3 PF02487.17 CDI75072.1 - 0.2 10.6 3.1 0.2 10.6 3.1 1.1 1 0 0 1 1 1 0 CLN3 protein DUF3169 PF11368.8 CDI75072.1 - 0.23 10.9 2.5 0.31 10.5 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) DUF4637 PF15470.6 CDI75072.1 - 0.27 10.9 8.7 0.35 10.6 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) SID-1_RNA_chan PF13965.6 CDI75072.1 - 0.28 9.5 3.0 0.27 9.6 3.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Sporozoite_P67 PF05642.11 CDI75072.1 - 0.28 9.2 2.5 0.33 9.0 2.5 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF1676 PF07898.13 CDI75072.1 - 0.31 11.1 2.4 0.37 10.8 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) O-antigen_lig PF13425.6 CDI75072.1 - 0.34 9.6 2.6 0.34 9.7 2.6 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PigN PF04987.14 CDI75072.1 - 0.35 9.7 1.5 0.33 9.8 1.5 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Acatn PF13000.7 CDI75072.1 - 0.36 9.3 1.3 0.4 9.1 1.3 1.0 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 DUF4006 PF13179.6 CDI75072.1 - 0.41 10.6 4.3 0.32 11.0 2.9 1.6 2 0 0 2 2 1 0 Family of unknown function (DUF4006) FPN1 PF06963.12 CDI75072.1 - 0.43 9.1 1.8 0.41 9.2 1.8 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Ureide_permease PF07168.11 CDI75072.1 - 0.48 9.1 1.2 0.5 9.1 1.2 1.1 1 0 0 1 1 1 0 Ureide permease Dynamin_N PF00350.23 CDI75072.1 - 0.55 10.3 4.1 0.61 10.1 4.1 1.1 1 0 0 1 1 1 0 Dynamin family DUF4956 PF16316.5 CDI75072.1 - 0.58 9.8 1.9 0.66 9.6 1.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4956) K_trans PF02705.16 CDI75072.1 - 0.6 8.5 1.3 0.6 8.6 1.3 1.0 1 0 0 1 1 1 0 K+ potassium transporter EIIBC-GUT_N PF03612.14 CDI75072.1 - 0.64 9.7 5.2 0.79 9.4 5.2 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Pep1_7 PF17232.2 CDI75072.1 - 0.65 10.5 7.4 0.92 10.0 7.4 1.2 1 0 0 1 1 1 0 Elicitor peptide 1-7 DUF2722 PF10846.8 CDI75072.1 - 0.7 8.8 12.7 0.79 8.6 12.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TERB2 PF15101.6 CDI75072.1 - 0.82 9.7 8.7 0.87 9.6 8.7 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4199 PF13858.6 CDI75072.1 - 0.97 9.8 2.2 1.1 9.6 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF2681 PF10883.8 CDI75072.1 - 1 9.8 15.9 0.081 13.3 11.4 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF2681) GTA_holin_3TM PF11351.8 CDI75072.1 - 1.5 9.4 6.1 1.8 9.1 6.1 1.2 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release SHR3_chaperone PF08229.11 CDI75072.1 - 1.6 7.7 9.3 2 7.4 9.3 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 Mem_trans PF03547.18 CDI75072.1 - 1.7 7.0 3.1 1.8 6.9 3.1 1.0 1 0 0 1 1 1 0 Membrane transport protein MscL PF01741.18 CDI75072.1 - 2.3 8.6 4.2 2.4 8.5 3.7 1.3 1 1 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL GRP PF07172.11 CDI75072.1 - 2.9 8.6 4.8 3.9 8.2 4.5 1.4 1 1 0 1 1 1 0 Glycine rich protein family Baculo_11_kDa PF06143.11 CDI75072.1 - 7.5 6.2 7.3 0.88 9.2 2.3 2.0 1 1 1 2 2 2 0 Baculovirus 11 kDa family Activator_LAG-3 PF11498.8 CDI75072.1 - 9.6 5.0 22.6 11 4.9 22.6 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 RskA PF10099.9 CDI75074.1 - 0.0015 18.9 8.9 0.0015 18.9 8.9 10.2 3 2 3 7 7 7 1 Anti-sigma-K factor rskA PAP2 PF01569.21 CDI75074.1 - 0.019 14.7 0.1 0.17 11.7 0.1 2.7 1 0 0 1 1 1 0 PAP2 superfamily Macoilin PF09726.9 CDI75075.1 - 0.76 8.3 56.2 0.87 8.1 56.2 1.0 1 0 0 1 1 1 0 Macoilin family RskA PF10099.9 CDI75075.1 - 7.4 6.8 23.0 0.048 14.0 14.0 2.0 2 1 0 2 2 2 0 Anti-sigma-K factor rskA Ribosomal_60s PF00428.19 CDI75076.1 - 0.012 16.2 7.5 0.012 16.2 7.5 5.7 3 3 1 4 4 4 0 60s Acidic ribosomal protein DUF2368 PF10166.9 CDI75076.1 - 1.5 8.5 9.5 3.1 7.4 9.5 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) DDRGK PF09756.9 CDI75076.1 - 7.4 6.1 29.2 1.7 8.2 18.0 2.2 2 0 0 2 2 2 0 DDRGK domain DUF812 PF05667.11 CDI75077.1 - 0.00099 18.1 20.2 0.00099 18.1 20.2 3.1 2 1 0 3 3 3 2 Protein of unknown function (DUF812) Spt20 PF12090.8 CDI75078.1 - 0.46 10.1 34.0 0.48 10.0 34.0 1.1 1 0 0 1 1 1 0 Spt20 family MMM1 PF10296.9 CDI75078.1 - 3.4 6.6 11.0 3.5 6.6 11.0 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 SYF2 PF08231.12 CDI75081.1 - 0.012 16.1 1.6 0.015 15.7 1.6 1.1 1 0 0 1 1 1 0 SYF2 splicing factor DUF4179 PF13786.6 CDI75081.1 - 0.013 16.0 1.7 0.013 16.0 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) TFIIA PF03153.13 CDI75081.1 - 0.12 12.3 20.9 0.14 12.1 20.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1499 PF07386.11 CDI75081.1 - 1.1 9.8 7.3 2.2 8.8 7.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1499) TPP_enzyme_N PF02776.18 CDI75081.1 - 2.4 7.7 18.4 0.11 12.1 10.4 2.0 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Spt20 PF12090.8 CDI75081.1 - 7.8 6.0 19.1 11 5.5 19.1 1.3 1 0 0 1 1 1 0 Spt20 family PT PF04886.12 CDI75082.1 - 5e-12 45.2 18.9 2.4e-05 23.8 1.0 4.1 1 1 2 3 3 3 3 PT repeat UbiA PF01040.18 CDI75082.1 - 1.4e-11 44.2 1.2 5.2e-11 42.3 0.0 2.0 2 0 0 2 2 2 1 UbiA prenyltransferase family SR-25 PF10500.9 CDI75082.1 - 9.4e-07 28.7 21.2 9.4e-07 28.7 21.2 2.8 2 1 1 3 3 2 1 Nuclear RNA-splicing-associated protein SDA1 PF05285.12 CDI75082.1 - 0.0019 17.7 27.0 0.003 17.0 27.0 1.3 1 0 0 1 1 1 1 SDA1 Pex14_N PF04695.13 CDI75082.1 - 0.0035 18.0 15.9 0.0035 18.0 15.9 3.4 2 1 1 3 3 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region AUX_IAA PF02309.16 CDI75082.1 - 0.0081 16.0 1.0 0.0081 16.0 1.0 2.2 2 0 0 2 2 2 1 AUX/IAA family FAM60A PF15396.6 CDI75082.1 - 0.077 13.0 35.4 0.17 11.9 7.7 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Velvet PF11754.8 CDI75082.1 - 0.8 9.6 42.9 0.086 12.8 16.8 2.3 2 0 0 2 2 2 0 Velvet factor CDC45 PF02724.14 CDI75082.1 - 1.2 7.3 37.5 0.0083 14.5 10.8 2.1 2 0 0 2 2 2 0 CDC45-like protein NPR3 PF03666.13 CDI75082.1 - 3.5 6.3 42.9 0.055 12.3 14.4 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 PA26 PF04636.13 CDI75082.1 - 5.7 5.7 37.2 0.69 8.8 8.6 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Dus PF01207.17 CDI75083.1 - 1.9e-58 198.0 0.0 2.7e-51 174.5 0.0 2.0 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) BTB PF00651.31 CDI75084.1 - 5.7e-07 29.8 0.1 1.5e-06 28.4 0.1 1.7 1 1 0 1 1 1 1 BTB/POZ domain CLTH PF10607.9 CDI75085.1 - 2.8e-13 50.0 0.0 4.8e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Marek_A PF02124.15 CDI75087.1 - 0.17 11.7 0.0 2.9 7.7 0.0 2.1 2 0 0 2 2 2 0 Marek's disease glycoprotein A Otopetrin PF03189.13 CDI75091.1 - 0.0017 17.2 11.4 0.0083 15.0 11.4 2.0 1 1 0 1 1 1 1 Otopetrin MecA PF05389.12 CDI75091.1 - 0.0054 16.4 1.7 0.0054 16.4 1.7 2.5 2 0 0 2 2 2 1 Negative regulator of genetic competence (MecA) RPOL_N PF14700.6 CDI75091.1 - 0.023 14.1 32.3 0.25 10.7 11.6 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal SpoIIP PF07454.11 CDI75091.1 - 0.053 13.0 35.3 0.28 10.6 14.4 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) EIF4E-T PF10477.9 CDI75091.1 - 0.054 12.3 37.7 0.013 14.3 11.3 2.1 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Eapp_C PF10238.9 CDI75091.1 - 0.14 12.2 33.2 0.38 10.8 11.5 2.5 2 0 0 2 2 2 0 E2F-associated phosphoprotein PNISR PF15996.5 CDI75091.1 - 0.19 12.0 37.5 1.2 9.4 16.9 2.4 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR HNOBA PF07701.14 CDI75091.1 - 0.19 11.1 19.4 0.1 12.0 2.9 2.2 2 0 0 2 2 2 0 Heme NO binding associated CDC45 PF02724.14 CDI75091.1 - 0.27 9.5 25.6 0.1 10.8 4.3 2.1 2 0 0 2 2 2 0 CDC45-like protein FAM76 PF16046.5 CDI75091.1 - 0.48 9.7 33.7 0.79 9.0 14.5 2.1 2 0 0 2 2 2 0 FAM76 protein Band_3_cyto PF07565.13 CDI75091.1 - 0.69 9.7 29.1 0.95 9.2 10.2 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain CNDH2_C PF16858.5 CDI75091.1 - 0.99 9.2 32.4 2.7 7.8 14.4 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term eIF-3_zeta PF05091.12 CDI75091.1 - 1.2 8.0 46.4 0.029 13.4 11.4 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Dpy19 PF10034.9 CDI75091.1 - 1.2 7.2 5.8 3.2 5.8 0.2 2.1 2 0 0 2 2 2 0 Q-cell neuroblast polarisation DUF5523 PF17661.1 CDI75091.1 - 1.5 8.5 37.9 0.14 11.8 9.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) MAT1 PF06391.13 CDI75091.1 - 1.5 8.6 38.6 0.71 9.7 14.7 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 DUF4746 PF15928.5 CDI75091.1 - 1.8 7.9 28.6 0.21 11.0 10.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF2052 PF09747.9 CDI75091.1 - 1.9 8.6 34.0 3.8 7.6 9.9 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SLC12 PF03522.15 CDI75091.1 - 1.9 7.4 35.1 1.3 8.0 9.9 2.2 2 0 0 2 2 2 0 Solute carrier family 12 ALMT PF11744.8 CDI75091.1 - 2.6 6.8 26.6 0.22 10.3 3.1 2.2 2 0 0 2 2 2 0 Aluminium activated malate transporter MPM1 PF17234.2 CDI75091.1 - 3.4 7.9 37.6 0.68 10.2 12.9 2.3 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 EOS1 PF12326.8 CDI75091.1 - 4.5 7.2 22.3 0.11 12.4 1.3 2.4 2 0 0 2 2 2 0 N-glycosylation protein PTPRCAP PF15713.5 CDI75091.1 - 5.1 7.4 42.5 1.8 8.9 12.3 2.5 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DUF1764 PF08576.10 CDI75091.1 - 6.4 7.7 33.7 6 7.8 13.6 2.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) SID-1_RNA_chan PF13965.6 CDI75091.1 - 6.9 4.9 19.2 0.12 10.7 0.3 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Dynamin_N PF00350.23 CDI75091.1 - 7.1 6.7 16.3 3.4 7.7 3.4 2.3 2 0 0 2 2 2 0 Dynamin family Peroxin-13_N PF04088.13 CDI75091.1 - 8.9 6.6 22.1 2.4 8.4 5.3 2.7 2 0 0 2 2 2 0 Peroxin 13, N-terminal region RskA PF10099.9 CDI75092.1 - 0.0012 19.2 0.0 0.0012 19.2 0.0 10.7 4 3 2 7 7 7 3 Anti-sigma-K factor rskA Trypsin_2 PF13365.6 CDI75093.1 - 1.1e-16 62.1 0.2 4e-16 60.3 0.2 2.0 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 CDI75093.1 - 9.3e-06 25.6 3.4 1.5e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 Trypsin DUF4667 PF15700.5 CDI75094.1 - 0.0025 17.9 33.4 0.0057 16.8 11.6 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF4667) Spt20 PF12090.8 CDI75094.1 - 0.0048 16.5 18.2 0.0048 16.5 18.2 4.1 3 1 0 3 3 3 2 Spt20 family RskA PF10099.9 CDI75094.1 - 0.066 13.5 100.5 0.27 11.5 22.5 4.7 2 1 2 4 4 4 0 Anti-sigma-K factor rskA Rxt3 PF08642.10 CDI75094.1 - 0.14 12.9 22.6 1.9 9.3 0.7 4.3 4 0 0 4 4 4 0 Histone deacetylation protein Rxt3 DUF4834 PF16118.5 CDI75094.1 - 2.2 9.3 49.9 0.63 11.0 7.5 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) rRNA_processing PF08524.11 CDI75094.1 - 4.2 7.4 45.6 0.34 10.9 4.7 4.1 4 0 0 4 4 4 0 rRNA processing DUF4207 PF13904.6 CDI75094.1 - 7.1 6.3 62.0 0.066 12.9 6.5 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4207) DUF2722 PF10846.8 CDI75095.1 - 0.0019 17.2 8.9 0.0019 17.2 8.9 4.5 4 0 0 4 4 4 3 Protein of unknown function (DUF2722) DUF4667 PF15700.5 CDI75096.1 - 0.0013 18.9 3.9 0.0017 18.5 3.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4667) FAM176 PF14851.6 CDI75096.1 - 0.0044 16.7 0.7 0.0044 16.7 0.7 1.5 2 0 0 2 2 2 1 FAM176 family zf-B_box PF00643.24 CDI75096.1 - 0.0066 16.6 0.8 0.011 15.8 0.8 1.3 1 0 0 1 1 1 1 B-box zinc finger DUF719 PF05334.13 CDI75096.1 - 0.008 16.4 2.5 0.008 16.4 2.5 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF719) DUF4179 PF13786.6 CDI75096.1 - 0.019 15.4 0.0 0.072 13.6 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4179) eIF-3_zeta PF05091.12 CDI75096.1 - 0.027 13.5 7.0 0.031 13.3 7.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NLRC4_HD PF17889.1 CDI75096.1 - 0.027 14.8 0.5 0.027 14.8 0.5 1.6 2 0 0 2 2 1 0 NLRC4 helical domain RskA PF10099.9 CDI75096.1 - 0.034 14.5 30.5 0.85 9.9 30.5 2.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA SDF PF00375.18 CDI75096.1 - 0.052 12.6 0.7 0.061 12.3 0.0 1.4 2 0 0 2 2 2 0 Sodium:dicarboxylate symporter family PA26 PF04636.13 CDI75096.1 - 0.12 11.2 5.6 0.048 12.6 3.0 1.4 1 1 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF2227 PF09988.9 CDI75096.1 - 0.13 12.1 0.8 0.23 11.4 0.1 1.6 2 0 0 2 2 2 0 Uncharacterized metal-binding protein (DUF2227) TERB2 PF15101.6 CDI75096.1 - 0.15 12.1 14.7 0.09 12.8 8.0 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF4834 PF16118.5 CDI75096.1 - 0.15 13.0 9.3 0.068 14.1 5.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) OSTbeta PF15048.6 CDI75096.1 - 0.16 12.1 3.1 0.17 12.0 0.5 2.0 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein THOC2_N PF16134.5 CDI75096.1 - 0.16 10.6 5.8 0.22 10.1 5.8 1.2 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Presenilin PF01080.17 CDI75096.1 - 0.17 10.7 8.5 0.22 10.2 8.5 1.2 1 0 0 1 1 1 0 Presenilin DUF4865 PF16157.5 CDI75096.1 - 0.18 11.7 8.6 0.37 10.7 1.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4865) Folate_carrier PF01770.18 CDI75096.1 - 0.24 10.1 0.7 0.39 9.4 0.7 1.3 1 0 0 1 1 1 0 Reduced folate carrier CSG2 PF16965.5 CDI75096.1 - 0.26 10.2 0.5 0.4 9.6 0.5 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator INSIG PF07281.12 CDI75096.1 - 0.36 10.4 1.8 0.34 10.5 0.3 1.6 2 0 0 2 2 2 0 Insulin-induced protein (INSIG) DUF4199 PF13858.6 CDI75096.1 - 0.5 10.7 4.9 0.44 10.9 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) PAPA-1 PF04795.12 CDI75096.1 - 0.59 11.0 14.6 0.36 11.6 4.8 2.5 2 1 0 2 2 2 0 PAPA-1-like conserved region CLN3 PF02487.17 CDI75096.1 - 1.3 8.0 5.2 0.34 9.9 1.9 1.6 2 0 0 2 2 2 0 CLN3 protein DUF3824 PF12868.7 CDI75096.1 - 1.6 9.4 13.3 0.46 11.1 1.0 2.6 3 0 0 3 3 2 0 Domain of unknwon function (DUF3824) Connexin PF00029.19 CDI75096.1 - 1.6 8.4 5.6 0.2 11.4 1.9 1.5 2 0 0 2 2 2 0 Connexin TMEM208_SND2 PF05620.11 CDI75096.1 - 1.7 8.4 7.1 0.16 11.7 2.4 1.7 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Chorion_2 PF03964.15 CDI75096.1 - 1.7 9.5 12.0 0.13 13.1 3.5 2.4 2 0 0 2 2 2 0 Chorion family 2 APG5 PF04106.12 CDI75096.1 - 1.9 8.0 11.4 6.4 6.3 11.4 1.8 1 1 0 1 1 1 0 Autophagy protein Apg5 EIIBC-GUT_N PF03612.14 CDI75096.1 - 4.8 6.9 12.4 2.3 7.9 7.4 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus AIF_C PF14721.6 CDI75096.1 - 5.4 7.4 9.5 1.5 9.2 3.7 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term G0-G1_switch_2 PF15103.6 CDI75096.1 - 7.6 7.0 9.1 1 9.8 2.9 2.2 2 0 0 2 2 2 0 G0/G1 switch protein 2 WASH-7_C PF14746.6 CDI75096.1 - 7.7 6.2 10.2 0.46 10.2 4.7 1.7 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal TetR_C_1 PF02909.17 CDI75096.1 - 9.4 6.0 10.1 0.17 11.7 2.6 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain GON PF08685.11 CDI75097.1 - 0.03 14.2 0.2 0.051 13.5 0.2 1.4 1 0 0 1 1 1 0 GON domain Phage_int_SAM_1 PF02899.17 CDI75097.1 - 0.13 12.6 0.2 0.13 12.6 0.2 2.5 3 1 0 3 3 3 0 Phage integrase, N-terminal SAM-like domain DUF87 PF01935.17 CDI75097.1 - 0.25 11.4 9.6 0.21 11.7 2.6 2.1 1 1 1 2 2 2 0 Helicase HerA, central domain PBP_sp32 PF07222.12 CDI75097.1 - 0.31 10.5 6.4 0.56 9.6 6.4 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Chalcone_2 PF16035.5 CDI75097.1 - 0.32 10.7 4.4 1.9 8.2 0.2 2.2 2 0 0 2 2 2 0 Chalcone isomerase like Spt20 PF12090.8 CDI75097.1 - 0.38 10.3 11.7 0.62 9.6 11.7 1.3 1 0 0 1 1 1 0 Spt20 family DUF4799 PF16056.5 CDI75097.1 - 0.67 9.0 6.6 1.1 8.3 6.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4799) DASH_Dam1 PF08653.10 CDI75097.1 - 0.77 9.6 6.2 5.5 6.9 0.3 3.5 4 0 0 4 4 4 0 DASH complex subunit Dam1 Occludin_ELL PF07303.13 CDI75097.1 - 0.9 10.3 14.3 1.9 9.3 0.8 3.1 2 1 1 3 3 3 0 Occludin homology domain DUF4207 PF13904.6 CDI75097.1 - 3.2 7.4 17.1 1.8 8.2 7.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) AAA_22 PF13401.6 CDI75097.1 - 3.6 7.9 11.1 0.73 10.1 1.2 2.9 1 1 1 2 2 2 0 AAA domain DUF2722 PF10846.8 CDI75098.1 - 0.0069 15.4 2.9 0.0069 15.4 2.9 5.0 5 1 0 5 5 5 2 Protein of unknown function (DUF2722) Med15 PF09606.10 CDI75098.1 - 0.052 12.2 39.5 0.074 11.7 5.5 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Trp_oprn_chp PF09534.10 CDI75098.1 - 0.28 11.0 12.8 0.62 9.8 0.2 4.1 3 1 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Presenilin PF01080.17 CDI75098.1 - 0.69 8.6 29.7 0.87 8.3 4.0 3.2 3 0 0 3 3 3 0 Presenilin BAF1_ABF1 PF04684.13 CDI75098.1 - 0.81 8.7 24.3 0.63 9.0 6.4 3.2 3 0 0 3 3 3 0 BAF1 / ABF1 chromatin reorganising factor FKBP_N PF01346.18 CDI75098.1 - 0.95 10.5 21.0 4 8.5 4.4 3.9 4 0 0 4 4 4 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase RskA PF10099.9 CDI75098.1 - 5.2 7.3 40.6 0.026 14.8 9.8 3.3 1 1 1 3 3 3 0 Anti-sigma-K factor rskA FAM220 PF15487.6 CDI75099.1 - 1.9 8.0 8.0 3.3 7.3 8.0 1.3 1 0 0 1 1 1 0 FAM220 family DUF2520 PF10728.9 CDI75100.1 - 0.043 13.6 0.1 0.11 12.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2520) DS PF01916.17 CDI75101.1 - 5.4e-06 25.9 1.4 8.1e-06 25.3 1.4 1.2 1 0 0 1 1 1 1 Deoxyhypusine synthase rRNA_processing PF08524.11 CDI75101.1 - 0.00082 19.4 13.6 0.001 19.1 13.6 1.0 1 0 0 1 1 1 1 rRNA processing TMEM51 PF15345.6 CDI75101.1 - 0.002 18.0 12.1 0.0024 17.7 12.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 PAP_PilO PF06864.12 CDI75101.1 - 0.0071 15.2 5.6 0.0078 15.1 5.6 1.0 1 0 0 1 1 1 1 Pilin accessory protein (PilO) SprA-related PF12118.8 CDI75101.1 - 0.034 13.3 24.6 0.038 13.1 24.6 1.0 1 0 0 1 1 1 0 SprA-related family Conotoxin PF02950.17 CDI75101.1 - 0.061 14.3 6.0 0.095 13.7 2.8 2.1 2 0 0 2 2 2 0 Conotoxin CCSAP PF15748.5 CDI75101.1 - 0.072 13.3 16.0 0.086 13.0 16.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated TCP PF03634.13 CDI75101.1 - 0.072 13.6 14.5 0.089 13.4 14.5 1.1 1 0 0 1 1 1 0 TCP family transcription factor ABC2_membrane_2 PF12679.7 CDI75101.1 - 0.074 12.3 0.7 0.077 12.3 0.7 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Serinc PF03348.15 CDI75101.1 - 0.12 11.2 10.1 0.14 11.1 10.1 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Velvet PF11754.8 CDI75101.1 - 0.13 12.1 14.4 0.15 12.0 14.4 1.0 1 0 0 1 1 1 0 Velvet factor Presenilin PF01080.17 CDI75101.1 - 0.14 10.9 15.0 0.16 10.7 15.0 1.1 1 0 0 1 1 1 0 Presenilin DUF572 PF04502.13 CDI75101.1 - 0.2 11.2 13.9 0.22 11.1 13.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) AP3D1 PF06375.11 CDI75101.1 - 0.2 11.9 16.4 0.24 11.6 16.4 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF1980 PF09323.10 CDI75101.1 - 0.21 11.5 8.1 0.28 11.1 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) SCF PF02404.15 CDI75101.1 - 0.22 10.8 4.3 0.27 10.6 4.3 1.1 1 0 0 1 1 1 0 Stem cell factor DcuA_DcuB PF03605.14 CDI75101.1 - 0.37 9.6 1.3 0.37 9.6 1.3 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter FHIPEP PF00771.20 CDI75101.1 - 0.42 9.0 6.0 0.47 8.9 6.0 1.1 1 0 0 1 1 1 0 FHIPEP family O-antigen_lig PF13425.6 CDI75101.1 - 0.44 9.3 1.5 0.52 9.0 1.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein TFIIA PF03153.13 CDI75101.1 - 0.44 10.5 22.6 0.53 10.2 22.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zip PF02535.22 CDI75101.1 - 0.74 9.0 8.7 0.83 8.8 8.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter FAM176 PF14851.6 CDI75101.1 - 0.89 9.2 11.6 0.067 12.9 4.9 1.9 1 1 1 2 2 2 0 FAM176 family Corona_nucleoca PF00937.18 CDI75101.1 - 0.95 8.4 19.7 1 8.3 19.7 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein SR-25 PF10500.9 CDI75101.1 - 0.97 9.0 35.8 1.6 8.3 35.8 1.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAM199X PF15814.5 CDI75101.1 - 0.98 8.4 17.7 1.2 8.2 17.7 1.0 1 0 0 1 1 1 0 Protein family FAM199X Neur_chan_memb PF02932.16 CDI75101.1 - 1.1 9.3 9.8 1.2 9.1 9.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PA26 PF04636.13 CDI75101.1 - 1.6 7.6 11.0 1.7 7.5 11.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) AUX_IAA PF02309.16 CDI75101.1 - 1.8 8.3 11.0 2 8.2 11.0 1.0 1 0 0 1 1 1 0 AUX/IAA family Suf PF05843.14 CDI75101.1 - 2 8.3 18.0 2.4 8.1 18.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Peptidase_S64 PF08192.11 CDI75101.1 - 2.3 6.6 18.6 2.5 6.5 18.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 CSG2 PF16965.5 CDI75101.1 - 2.4 7.0 7.0 2.9 6.7 7.0 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator ALMT PF11744.8 CDI75101.1 - 2.5 6.8 12.1 3.1 6.5 12.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DivIC PF04977.15 CDI75101.1 - 4.7 7.1 16.2 6.7 6.6 16.2 1.2 1 0 0 1 1 1 0 Septum formation initiator WRNPLPNID PF15017.6 CDI75101.1 - 4.7 8.1 11.4 14 6.6 7.8 2.1 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box MscS_TM PF12794.7 CDI75101.1 - 7.1 5.4 8.0 8.7 5.1 8.0 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Hid1 PF12722.7 CDI75101.1 - 7.4 4.6 15.7 8.1 4.4 15.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RRP14 PF15459.6 CDI75101.1 - 8.4 7.1 16.4 3.4 8.4 11.4 2.2 2 0 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 SID-1_RNA_chan PF13965.6 CDI75101.1 - 8.9 4.6 8.3 12 4.2 8.3 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Ndc1_Nup PF09531.10 CDI75101.1 - 9.3 4.8 17.1 12 4.4 17.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TMEM51 PF15345.6 CDI75102.1 - 0.0052 16.7 24.9 0.0052 16.7 24.9 1.8 1 1 1 2 2 2 1 Transmembrane protein 51 Presenilin PF01080.17 CDI75102.1 - 0.019 13.8 30.0 0.022 13.5 30.0 1.2 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 CDI75102.1 - 0.056 12.4 23.4 0.064 12.2 23.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SR-25 PF10500.9 CDI75102.1 - 0.39 10.3 38.4 0.059 13.0 33.0 2.0 1 1 1 2 2 1 0 Nuclear RNA-splicing-associated protein DUF572 PF04502.13 CDI75102.1 - 0.41 10.2 27.5 0.52 9.9 27.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) SHR3_chaperone PF08229.11 CDI75102.1 - 0.42 9.5 15.3 0.65 8.9 15.3 1.4 1 0 0 1 1 1 0 ER membrane protein SH3 Plant_vir_prot PF01307.17 CDI75102.1 - 0.86 9.9 5.1 0.65 10.2 3.0 2.0 2 1 0 2 2 2 0 Plant viral movement protein 7TM_GPCR_Srw PF10324.9 CDI75102.1 - 0.93 8.7 4.9 1.1 8.4 4.9 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw SART-1 PF03343.13 CDI75102.1 - 1 7.9 25.7 1.1 7.7 25.7 1.0 1 0 0 1 1 1 0 SART-1 family GRP PF07172.11 CDI75102.1 - 1.2 9.9 13.4 0.18 12.5 7.7 2.4 1 1 1 2 2 2 0 Glycine rich protein family TAS2R PF05296.13 CDI75102.1 - 1.3 8.1 5.1 1.5 7.8 5.1 1.2 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) PA26 PF04636.13 CDI75102.1 - 1.6 7.6 21.1 1.7 7.5 21.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) ALG3 PF05208.13 CDI75102.1 - 1.8 7.9 6.1 2.4 7.5 6.1 1.1 1 0 0 1 1 1 0 ALG3 protein PAT1 PF09770.9 CDI75102.1 - 2.8 6.1 33.9 3.7 5.7 33.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2227 PF09988.9 CDI75102.1 - 2.9 7.7 5.6 5.4 6.9 5.6 1.5 1 0 0 1 1 1 0 Uncharacterized metal-binding protein (DUF2227) RIFIN PF02009.16 CDI75102.1 - 3.2 7.5 21.7 3.9 7.3 21.7 1.1 1 0 0 1 1 1 0 Rifin Cwf_Cwc_15 PF04889.12 CDI75102.1 - 4.8 6.8 29.4 0.04 13.7 14.9 2.0 1 1 1 2 2 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 CDI75102.1 - 4.9 7.6 10.7 17 5.8 0.0 2.1 1 1 1 2 2 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal XRCC4 PF06632.12 CDI75102.1 - 5.4 5.8 23.3 7.5 5.3 23.3 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Corona_nucleoca PF00937.18 CDI75102.1 - 6.1 5.8 26.8 6.3 5.7 26.8 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Serinc PF03348.15 CDI75102.1 - 6.1 5.6 20.4 5.7 5.7 19.7 1.3 1 1 0 1 1 1 0 Serine incorporator (Serinc) SID-1_RNA_chan PF13965.6 CDI75102.1 - 7.7 4.8 18.0 9.2 4.5 17.5 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 G6B PF15096.6 CDI75102.1 - 8.1 6.2 8.6 3.5 7.4 6.1 1.6 1 1 1 2 2 2 0 G6B family FAM176 PF14851.6 CDI75102.1 - 8.6 6.0 24.1 0.095 12.4 11.5 2.1 1 1 1 2 2 2 0 FAM176 family AAA_23 PF13476.6 CDI75102.1 - 9.2 6.7 26.6 11 6.5 26.6 1.1 1 0 0 1 1 1 0 AAA domain MLANA PF14991.6 CDI75102.1 - 9.7 6.5 9.1 6.9 7.0 7.0 1.8 1 1 1 2 2 2 0 Protein melan-A RskA PF10099.9 CDI75103.1 - 0.00012 22.4 38.3 0.093 13.0 7.2 5.1 4 1 0 4 4 4 3 Anti-sigma-K factor rskA AAA PF00004.29 CDI75103.1 - 0.00082 19.8 0.6 0.00082 19.8 0.6 3.2 4 1 1 5 5 5 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDI75103.1 - 0.0012 19.3 0.0 0.0012 19.3 0.0 3.6 3 1 1 4 4 3 1 AAA ATPase domain AAA_5 PF07728.14 CDI75103.1 - 0.0013 18.7 0.4 0.0042 17.1 0.1 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) SR-25 PF10500.9 CDI75103.1 - 0.0085 15.7 27.8 0.0085 15.7 27.8 4.4 2 2 1 3 3 1 1 Nuclear RNA-splicing-associated protein Mg_chelatase PF01078.21 CDI75103.1 - 0.018 14.4 1.0 0.34 10.2 0.1 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CDI75103.1 - 0.024 14.9 0.1 0.024 14.9 0.1 3.0 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 CDI75103.1 - 0.03 14.1 0.1 0.03 14.1 0.1 2.6 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 CDI75103.1 - 0.033 13.8 1.8 0.11 12.1 1.8 1.8 1 0 0 1 1 1 0 AAA domain DUF2434 PF10361.9 CDI75103.1 - 0.05 12.6 0.5 0.14 11.1 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2434) Bac_DnaA PF00308.18 CDI75103.1 - 0.056 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein ATPase_2 PF01637.18 CDI75103.1 - 0.27 11.1 1.2 13 5.6 0.0 2.8 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 CDI75103.1 - 0.53 10.6 5.3 0.25 11.7 0.3 2.6 3 1 0 3 3 3 0 AAA domain PPP4R2 PF09184.11 CDI75103.1 - 2.2 7.8 29.1 0.92 9.0 14.2 2.5 2 0 0 2 2 2 0 PPP4R2 FHIPEP PF00771.20 CDI75103.1 - 4.6 5.6 18.1 0.29 9.5 2.6 2.3 2 0 0 2 2 2 0 FHIPEP family LAP1C PF05609.12 CDI75103.1 - 6.5 5.7 39.7 5 6.1 13.2 2.3 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Pkinase PF00069.25 CDI75105.1 - 1.8e-10 40.6 0.0 1.8e-10 40.6 0.0 3.6 4 1 1 5 5 3 1 Protein kinase domain EF-hand_1 PF00036.32 CDI75105.1 - 3.8e-08 32.3 0.0 0.076 12.6 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 CDI75105.1 - 1.2e-06 27.7 0.6 1.3 8.7 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 CDI75105.1 - 2.7e-06 26.8 0.1 0.036 14.0 0.0 3.4 3 0 0 3 3 3 1 EF-hand domain DUF2722 PF10846.8 CDI75105.1 - 3.4e-06 26.3 20.6 0.00011 21.3 2.3 5.3 4 1 1 5 5 3 3 Protein of unknown function (DUF2722) EF-hand_7 PF13499.6 CDI75105.1 - 5e-06 26.9 0.0 0.0013 19.1 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 CDI75105.1 - 0.00018 21.3 0.1 0.73 9.7 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain pair TFIIA PF03153.13 CDI75105.1 - 0.00068 19.7 6.4 0.00068 19.7 6.4 4.9 4 1 0 4 4 3 2 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI75105.1 - 0.0017 18.4 51.6 0.03 14.3 3.6 4.5 4 0 0 4 4 4 2 Suppressor of forked protein (Suf) DDHD PF02862.17 CDI75105.1 - 0.011 15.9 0.7 0.011 15.9 0.7 4.8 2 1 0 3 3 2 0 DDHD domain Cytochrom_B558a PF05038.13 CDI75105.1 - 0.067 12.8 0.1 0.067 12.8 0.1 2.2 3 0 0 3 3 3 0 Cytochrome Cytochrome b558 alpha-subunit Connexin PF00029.19 CDI75105.1 - 0.072 12.8 27.5 1.5 8.5 3.6 4.2 4 0 0 4 4 4 0 Connexin BORG_CEP PF14957.6 CDI75105.1 - 0.11 13.7 31.7 5.2 8.3 6.4 4.6 4 0 0 4 4 4 0 Cdc42 effector RPOL_N PF14700.6 CDI75105.1 - 0.19 11.1 37.2 0.027 13.9 4.0 4.2 4 0 0 4 4 4 0 DNA-directed RNA polymerase N-terminal Shadoo PF14999.6 CDI75105.1 - 0.25 11.5 0.0 0.25 11.5 0.0 9.0 5 3 2 8 8 4 0 Shadow of prion protein, neuroprotective TMEM71 PF15121.6 CDI75105.1 - 0.28 10.9 4.6 0.13 12.0 0.8 2.4 2 0 0 2 2 2 0 TMEM71 protein family TOBE_2 PF08402.10 CDI75105.1 - 0.41 10.9 3.1 3 8.1 3.1 2.6 1 0 0 1 1 1 0 TOBE domain SpoIIP PF07454.11 CDI75105.1 - 0.8 9.1 47.7 1.9 7.9 4.3 4.1 4 0 0 4 4 4 0 Stage II sporulation protein P (SpoIIP) FHIPEP PF00771.20 CDI75105.1 - 3.5 6.0 33.5 0.37 9.2 0.5 4.3 4 0 0 4 4 4 0 FHIPEP family FAM76 PF16046.5 CDI75105.1 - 3.9 6.7 34.7 1.2 8.4 0.5 4.3 4 0 0 4 4 4 0 FAM76 protein CDC45 PF02724.14 CDI75105.1 - 9.3 4.4 37.5 0.43 8.8 4.9 4.2 4 0 0 4 4 4 0 CDC45-like protein TP_methylase PF00590.20 CDI75106.1 - 2.6e-09 37.3 0.0 3e-09 37.1 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases UQ_con PF00179.26 CDI75107.1 - 1.5e-47 160.8 0.1 1.7e-47 160.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDI75107.1 - 0.00028 20.6 0.0 0.00031 20.4 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CDI75107.1 - 0.01 16.1 0.0 0.013 15.8 0.0 1.2 1 0 0 1 1 1 0 RWD domain APG5 PF04106.12 CDI75108.1 - 1.4e-45 155.7 0.0 2e-45 155.1 0.0 1.3 1 0 0 1 1 1 1 Autophagy protein Apg5 DUF5327 PF17261.2 CDI75109.1 - 0.66 10.8 23.0 0.77 10.5 23.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5327) BRF1 PF07741.13 CDI75109.1 - 0.75 10.2 16.1 0.9 9.9 16.1 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Eapp_C PF10238.9 CDI75109.1 - 0.86 9.7 17.7 0.98 9.5 17.7 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein EIIBC-GUT_N PF03612.14 CDI75109.1 - 1.2 8.9 16.2 1.3 8.7 16.2 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus FYDLN_acid PF09538.10 CDI75109.1 - 1.2 9.9 11.5 1.2 9.8 11.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) MPM1 PF17234.2 CDI75109.1 - 1.2 9.4 17.7 1.4 9.2 17.7 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 DNA_pol3_a_NII PF11490.8 CDI75109.1 - 1.2 9.0 24.1 1.5 8.7 24.1 1.2 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II DUF4820 PF16091.5 CDI75109.1 - 1.3 8.3 15.5 1.4 8.2 15.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF3464 PF11947.8 CDI75109.1 - 1.5 8.6 18.0 1.6 8.5 18.0 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF3506 PF12014.8 CDI75109.1 - 2.1 8.4 9.2 2.8 7.9 9.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3506) Connexin PF00029.19 CDI75109.1 - 2.4 7.8 13.9 2.4 7.9 13.9 1.0 1 0 0 1 1 1 0 Connexin CobT PF06213.12 CDI75109.1 - 2.6 7.4 27.0 2.6 7.4 27.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TFB6 PF17110.5 CDI75109.1 - 3.2 7.5 12.6 3.6 7.3 12.6 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH FAM176 PF14851.6 CDI75109.1 - 3.2 7.4 13.3 3.7 7.2 13.3 1.1 1 0 0 1 1 1 0 FAM176 family DUF1682 PF07946.14 CDI75109.1 - 3.2 6.9 16.3 3.4 6.8 16.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) YABBY PF04690.13 CDI75109.1 - 3.2 8.3 13.6 3.4 8.2 13.6 1.1 1 0 0 1 1 1 0 YABBY protein V_ATPase_I PF01496.19 CDI75109.1 - 3.3 5.5 19.7 3.2 5.5 19.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2828 PF11443.8 CDI75109.1 - 3.3 5.7 17.5 3.2 5.7 17.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4746 PF15928.5 CDI75109.1 - 3.5 7.0 15.9 3.4 7.0 15.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SpoIIP PF07454.11 CDI75109.1 - 3.5 7.0 21.2 3.4 7.0 21.2 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) eIF3_subunit PF08597.10 CDI75109.1 - 3.6 7.4 19.3 3.7 7.4 19.3 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit AIF_C PF14721.6 CDI75109.1 - 3.6 7.9 14.2 3.6 8.0 14.2 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term GNAT_acetyltr_2 PF13718.6 CDI75109.1 - 3.7 6.9 13.4 3.9 6.8 13.4 1.0 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Afi1 PF07792.12 CDI75109.1 - 3.9 8.0 17.8 4 7.9 17.8 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Peptidase_S49_N PF08496.10 CDI75109.1 - 4.5 7.3 14.5 4.9 7.2 14.5 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal G0-G1_switch_2 PF15103.6 CDI75109.1 - 4.7 7.7 12.1 6 7.3 12.1 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 ATAD4 PF15321.6 CDI75109.1 - 4.7 8.6 13.7 5.3 8.4 13.7 1.2 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 DUF5308 PF17233.2 CDI75109.1 - 5.2 7.3 16.1 5.3 7.3 16.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Rxt3 PF08642.10 CDI75109.1 - 5.6 7.8 10.5 6.7 7.5 10.5 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Tim54 PF11711.8 CDI75109.1 - 5.7 5.6 17.5 5.6 5.6 17.5 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Endonuc_Holl PF10107.9 CDI75109.1 - 6.3 6.6 13.2 6.9 6.5 13.2 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase DUF3043 PF11241.8 CDI75109.1 - 6.5 6.8 13.9 7.4 6.6 13.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) HA2 PF04408.23 CDI75109.1 - 6.6 7.1 8.7 8.5 6.7 8.7 1.3 1 0 0 1 1 1 0 Helicase associated domain (HA2) CemA PF03040.14 CDI75109.1 - 7.1 6.5 8.4 8.6 6.2 8.4 1.1 1 0 0 1 1 1 0 CemA family TERB2 PF15101.6 CDI75109.1 - 7.3 6.6 26.3 7.3 6.6 26.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CCDC53 PF10152.9 CDI75109.1 - 7.5 7.0 21.1 8.8 6.7 21.1 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex eIF-3_zeta PF05091.12 CDI75109.1 - 7.5 5.4 26.2 7.1 5.5 26.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CPSF100_C PF13299.6 CDI75109.1 - 7.9 6.6 16.9 7.7 6.7 16.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CLN3 PF02487.17 CDI75109.1 - 8.2 5.4 15.3 8 5.4 15.3 1.0 1 0 0 1 1 1 0 CLN3 protein MMU163 PF17119.5 CDI75109.1 - 8.3 5.5 10.7 8.8 5.4 10.7 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Paf1 PF03985.13 CDI75109.1 - 8.4 5.3 22.4 7.8 5.4 22.4 1.0 1 0 0 1 1 1 0 Paf1 UPF0239 PF06783.11 CDI75109.1 - 9.3 6.5 11.2 13 6.1 11.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) MDM31_MDM32 PF08118.11 CDI75109.1 - 10 4.7 13.4 10 4.7 13.4 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Spt20 PF12090.8 CDI75110.1 - 0.00016 21.4 32.4 0.00019 21.2 32.4 1.3 1 0 0 1 1 1 1 Spt20 family Pex14_N PF04695.13 CDI75110.1 - 0.0051 17.5 18.8 0.0057 17.3 18.8 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DOCK_N PF16172.5 CDI75110.1 - 0.009 15.0 10.4 0.0095 14.9 10.4 1.0 1 0 0 1 1 1 1 DOCK N-terminus TFIIA PF03153.13 CDI75110.1 - 0.016 15.3 34.4 0.016 15.3 34.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CCDC53 PF10152.9 CDI75110.1 - 0.022 15.2 13.7 0.024 15.0 13.7 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Connexin PF00029.19 CDI75110.1 - 0.056 13.2 10.4 0.067 13.0 10.4 1.1 1 0 0 1 1 1 0 Connexin CobT PF06213.12 CDI75110.1 - 0.059 12.8 22.6 0.06 12.7 22.6 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Med15 PF09606.10 CDI75110.1 - 0.074 11.7 28.8 0.078 11.7 28.8 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SpoIIP PF07454.11 CDI75110.1 - 0.087 12.3 16.0 0.09 12.2 16.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Baculo_PP31 PF05311.11 CDI75110.1 - 0.095 12.2 13.3 0.095 12.2 13.3 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF3292 PF11696.8 CDI75110.1 - 0.12 10.7 10.8 0.14 10.5 10.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) EIIBC-GUT_N PF03612.14 CDI75110.1 - 0.14 11.8 12.4 0.17 11.6 12.4 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus PAXIP1_C PF15364.6 CDI75110.1 - 0.15 12.4 15.0 0.19 12.1 15.0 1.1 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein TERB2 PF15101.6 CDI75110.1 - 0.21 11.6 18.8 0.22 11.6 18.8 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Tim54 PF11711.8 CDI75110.1 - 0.21 10.3 11.7 0.24 10.2 11.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ureide_permease PF07168.11 CDI75110.1 - 0.22 10.2 7.9 0.25 10.1 7.9 1.0 1 0 0 1 1 1 0 Ureide permease DUF3408 PF11888.8 CDI75110.1 - 0.23 11.6 15.9 0.32 11.1 15.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) CPSF100_C PF13299.6 CDI75110.1 - 0.25 11.5 13.3 0.28 11.4 13.3 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Rxt3 PF08642.10 CDI75110.1 - 0.25 12.1 5.9 0.28 12.0 5.9 1.3 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 EPL1 PF10513.9 CDI75110.1 - 0.27 11.6 13.8 0.31 11.4 13.8 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like RPA43_OB PF17875.1 CDI75110.1 - 0.28 11.8 7.5 0.3 11.7 7.5 1.3 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Suf PF05843.14 CDI75110.1 - 0.29 11.1 16.1 0.32 10.9 16.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) ST7 PF04184.12 CDI75110.1 - 0.31 9.5 7.8 0.36 9.3 7.8 1.0 1 0 0 1 1 1 0 ST7 protein DDHD PF02862.17 CDI75110.1 - 0.32 11.1 14.9 0.34 11.0 14.9 1.1 1 0 0 1 1 1 0 DDHD domain Band_3_cyto PF07565.13 CDI75110.1 - 0.33 10.7 14.4 0.39 10.5 14.4 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DREPP PF05558.12 CDI75110.1 - 0.33 10.8 3.5 0.36 10.7 3.5 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Presenilin PF01080.17 CDI75110.1 - 0.36 9.6 18.6 0.37 9.5 18.6 1.0 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 CDI75110.1 - 0.37 9.7 20.3 0.37 9.7 20.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) baeRF_family12 PF18856.1 CDI75110.1 - 0.38 11.3 8.9 0.44 11.1 8.9 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 Scs3p PF10261.9 CDI75110.1 - 0.38 10.2 3.7 0.44 10.0 3.7 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM SID-1_RNA_chan PF13965.6 CDI75110.1 - 0.4 9.0 10.9 0.47 8.8 10.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF913 PF06025.12 CDI75110.1 - 0.42 9.5 9.2 0.45 9.4 9.2 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RBM39linker PF15519.6 CDI75110.1 - 0.43 11.7 14.3 0.7 11.0 14.3 1.4 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein AIF_C PF14721.6 CDI75110.1 - 0.6 10.5 11.8 0.79 10.1 11.8 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF3371 PF11851.8 CDI75110.1 - 0.61 11.2 14.4 0.81 10.8 14.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Peroxin-13_N PF04088.13 CDI75110.1 - 0.62 10.3 9.0 0.81 10.0 9.0 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region PIP5K PF01504.18 CDI75110.1 - 0.75 9.0 11.4 0.84 8.8 11.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase R_equi_Vir PF05526.11 CDI75110.1 - 0.87 9.4 5.3 1 9.2 5.3 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Gti1_Pac2 PF09729.9 CDI75110.1 - 0.87 9.7 13.2 1.1 9.4 13.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family RR_TM4-6 PF06459.12 CDI75110.1 - 0.93 9.3 16.9 0.98 9.2 16.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Coilin_N PF15862.5 CDI75110.1 - 1 9.2 16.5 1.7 8.5 16.5 1.4 1 0 0 1 1 1 0 Coilin N-terminus Folliculin PF11704.8 CDI75110.1 - 1.1 9.2 14.6 1.2 8.9 14.6 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Folate_carrier PF01770.18 CDI75110.1 - 1.1 8.0 8.4 1.1 7.9 8.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier DUF4746 PF15928.5 CDI75110.1 - 1.2 8.5 11.6 1.3 8.4 11.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PepSY_TM PF03929.16 CDI75110.1 - 1.2 8.8 8.4 1.3 8.6 8.4 1.1 1 0 0 1 1 1 0 PepSY-associated TM region CLN3 PF02487.17 CDI75110.1 - 1.2 8.1 12.3 1.3 8.0 12.3 1.0 1 0 0 1 1 1 0 CLN3 protein Bac_luciferase PF00296.20 CDI75110.1 - 1.3 8.4 7.2 1.6 8.1 7.2 1.0 1 0 0 1 1 1 0 Luciferase-like monooxygenase Peptidase_S15 PF02129.18 CDI75110.1 - 1.3 8.5 11.2 1.5 8.4 11.2 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) CSG2 PF16965.5 CDI75110.1 - 1.4 7.8 8.3 1.4 7.7 8.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator V_ATPase_I PF01496.19 CDI75110.1 - 1.5 6.7 17.0 1.4 6.7 17.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2367 PF10164.9 CDI75110.1 - 1.5 9.3 6.4 2.2 8.8 6.4 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) MMU163 PF17119.5 CDI75110.1 - 1.7 7.8 7.5 1.9 7.6 7.5 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis TFB6 PF17110.5 CDI75110.1 - 1.7 8.4 8.6 2 8.1 8.6 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Lin-8 PF03353.15 CDI75110.1 - 1.8 8.1 22.5 2 7.9 22.5 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist FHIPEP PF00771.20 CDI75110.1 - 1.8 6.9 8.5 1.8 6.9 8.5 1.1 1 0 0 1 1 1 0 FHIPEP family SLC12 PF03522.15 CDI75110.1 - 2.1 7.3 16.8 2 7.3 16.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Peptidase_U57 PF05582.12 CDI75110.1 - 2.1 7.5 10.6 2.3 7.4 10.6 1.2 1 0 0 1 1 1 0 YabG peptidase U57 BORG_CEP PF14957.6 CDI75110.1 - 2.2 9.5 10.9 2.6 9.2 10.9 1.2 1 0 0 1 1 1 0 Cdc42 effector DUF4407 PF14362.6 CDI75110.1 - 2.3 7.5 18.4 2.3 7.5 18.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SET PF00856.28 CDI75110.1 - 2.3 8.6 6.0 2.6 8.4 6.0 1.1 1 0 0 1 1 1 0 SET domain PAT1 PF09770.9 CDI75110.1 - 2.3 6.4 29.2 2.3 6.4 29.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4228 PF14009.6 CDI75110.1 - 2.6 8.4 10.8 3 8.2 10.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) EOS1 PF12326.8 CDI75110.1 - 2.8 7.8 8.3 2.9 7.8 8.3 1.2 1 0 0 1 1 1 0 N-glycosylation protein Ctr PF04145.15 CDI75110.1 - 2.9 8.5 10.3 3.3 8.3 10.3 1.2 1 0 0 1 1 1 0 Ctr copper transporter family OATP PF03137.20 CDI75110.1 - 3 6.0 8.1 3.1 6.0 8.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2828 PF11443.8 CDI75110.1 - 3.1 5.8 16.3 3.3 5.7 16.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Hid1 PF12722.7 CDI75110.1 - 3.1 5.8 16.4 3.1 5.8 16.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3464 PF11947.8 CDI75110.1 - 3.1 7.5 15.6 3.9 7.2 15.6 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF1980 PF09323.10 CDI75110.1 - 3.2 7.6 10.8 3.6 7.5 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF2126 PF09899.9 CDI75110.1 - 3.2 5.7 11.3 3.6 5.5 11.3 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Paf1 PF03985.13 CDI75110.1 - 3.4 6.6 23.0 3.9 6.4 23.0 1.1 1 0 0 1 1 1 0 Paf1 DUF4175 PF13779.6 CDI75110.1 - 3.5 5.4 38.7 3.4 5.5 38.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) XAP5 PF04921.14 CDI75110.1 - 3.5 7.4 14.4 4.1 7.1 14.4 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator HCO3_cotransp PF00955.21 CDI75110.1 - 3.7 6.3 6.9 3.8 6.2 6.9 1.0 1 0 0 1 1 1 0 HCO3- transporter family Kei1 PF08552.11 CDI75110.1 - 3.9 7.3 10.2 4.5 7.1 10.2 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Sec62 PF03839.16 CDI75110.1 - 4.1 6.8 12.4 4.3 6.8 12.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF853 PF05872.12 CDI75110.1 - 4.4 5.8 12.6 4.7 5.7 12.6 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) MDM10 PF12519.8 CDI75110.1 - 4.7 6.0 13.7 4.8 5.9 13.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Neur_chan_memb PF02932.16 CDI75110.1 - 4.8 7.2 14.1 5 7.1 14.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Mem_trans PF03547.18 CDI75110.1 - 4.9 5.5 6.1 5.2 5.4 6.1 1.1 1 0 0 1 1 1 0 Membrane transport protein Serinc PF03348.15 CDI75110.1 - 5.1 5.9 10.2 5.5 5.8 10.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) SprA-related PF12118.8 CDI75110.1 - 5.6 6.0 31.3 5.6 6.0 31.3 1.1 1 0 0 1 1 1 0 SprA-related family MMR1 PF08505.10 CDI75110.1 - 5.7 7.2 22.7 6.3 7.0 22.7 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Zip PF02535.22 CDI75110.1 - 5.7 6.1 8.5 6.1 6.0 8.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter ALMT PF11744.8 CDI75110.1 - 6.4 5.5 14.1 6.4 5.5 14.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Glyco_transf_41 PF13844.6 CDI75110.1 - 6.4 5.1 9.5 7 5.0 9.5 1.0 1 0 0 1 1 1 0 Glycosyl transferase family 41 UPF0560 PF10577.9 CDI75110.1 - 6.8 5.1 24.0 7.5 4.9 24.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DcuA_DcuB PF03605.14 CDI75110.1 - 7.1 5.4 4.8 7.4 5.3 4.8 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Nucleoside_tran PF01733.18 CDI75110.1 - 7.3 5.9 6.8 8.5 5.7 6.8 1.1 1 0 0 1 1 1 0 Nucleoside transporter MTP18 PF10558.9 CDI75110.1 - 7.4 6.5 5.6 8.5 6.3 5.6 1.2 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) FTO_NTD PF12933.7 CDI75110.1 - 7.4 5.7 14.8 9.1 5.4 14.8 1.1 1 0 0 1 1 1 0 FTO catalytic domain FAM222A PF15258.6 CDI75110.1 - 7.6 5.5 24.5 7.8 5.5 24.5 1.0 1 0 0 1 1 1 0 Protein family of FAM222A DNA_pol_B_2 PF03175.13 CDI75110.1 - 7.7 5.3 7.5 8.6 5.1 7.5 1.0 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral Het-C PF07217.11 CDI75110.1 - 7.7 4.9 14.4 8.2 4.8 14.4 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C CDC45 PF02724.14 CDI75110.1 - 8.1 4.6 18.2 8.8 4.5 18.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Asparaginase_2 PF01112.18 CDI75110.1 - 8.4 5.3 8.9 9.1 5.2 8.9 1.1 1 0 0 1 1 1 0 Asparaginase DUF775 PF05603.12 CDI75110.1 - 8.8 5.8 16.2 13 5.2 16.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Ndc1_Nup PF09531.10 CDI75110.1 - 9.1 4.8 15.1 10 4.6 15.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Membralin PF09746.9 CDI75110.1 - 9.3 5.2 11.6 9.6 5.1 11.6 1.1 1 0 0 1 1 1 0 Tumour-associated protein Endonuc_Holl PF10107.9 CDI75110.1 - 9.7 6.0 13.4 12 5.7 13.4 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Otopetrin PF03189.13 CDI75110.1 - 9.7 4.9 12.1 11 4.8 12.1 1.0 1 0 0 1 1 1 0 Otopetrin DUF2784 PF10861.8 CDI75111.1 - 0.017 15.1 0.0 2.3 8.3 0.0 2.7 2 0 0 2 2 2 0 Protein of Unknown function (DUF2784) RskA PF10099.9 CDI75112.1 - 4.3e-07 30.4 15.1 3.4e-05 24.2 13.0 8.1 1 1 4 5 5 5 2 Anti-sigma-K factor rskA CNDH2_C PF16858.5 CDI75112.1 - 0.03 14.2 35.7 1 9.1 10.2 3.1 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term eIF-3_zeta PF05091.12 CDI75112.1 - 0.15 11.0 50.8 0.037 13.0 16.0 3.1 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ribosomal_S17e PF00833.18 CDI75113.1 - 2.9e-58 195.1 1.6 2.9e-58 195.1 1.6 3.0 3 0 0 3 3 3 1 Ribosomal S17 RskA PF10099.9 CDI75113.1 - 7e-06 26.4 61.7 0.00042 20.7 2.6 6.3 3 2 2 5 5 5 4 Anti-sigma-K factor rskA Lin-8 PF03353.15 CDI75113.1 - 0.00071 19.2 9.2 0.00071 19.2 9.2 4.0 4 0 0 4 4 4 1 Ras-mediated vulval-induction antagonist SPX PF03105.19 CDI75113.1 - 0.0033 17.4 9.6 0.0033 17.4 9.6 3.5 3 1 0 3 3 3 1 SPX domain UPF0564 PF10595.9 CDI75113.1 - 0.011 14.9 0.2 0.011 14.9 0.2 4.2 4 0 0 4 4 4 0 Uncharacterised protein family UPF0564 MFAP1 PF06991.11 CDI75113.1 - 0.011 15.6 4.6 0.011 15.6 4.6 4.4 5 0 0 5 5 5 0 Microfibril-associated/Pre-mRNA processing MPM1 PF17234.2 CDI75113.1 - 0.018 15.3 2.9 0.018 15.3 2.9 4.5 4 0 0 4 4 4 0 Mitochondrial peculiar membrane protein 1 TFIIA PF03153.13 CDI75113.1 - 0.22 11.5 107.8 0.018 15.1 27.9 4.4 3 1 1 4 4 4 0 Transcription factor IIA, alpha/beta subunit AAA_29 PF13555.6 CDI75114.1 - 0.00025 20.7 0.0 0.00079 19.1 0.0 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDI75114.1 - 0.00031 21.2 0.3 0.00031 21.2 0.3 2.0 1 1 1 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 CDI75114.1 - 0.0011 18.7 0.8 0.0011 18.7 0.8 2.3 1 1 1 2 2 1 1 AAA domain ATP_bind_1 PF03029.17 CDI75114.1 - 0.004 17.0 0.7 0.0066 16.3 0.7 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein NB-ARC PF00931.22 CDI75114.1 - 0.0067 15.7 0.1 0.0097 15.1 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain Zeta_toxin PF06414.12 CDI75114.1 - 0.0072 15.6 0.1 0.0072 15.6 0.1 1.7 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.6 CDI75114.1 - 0.0073 16.9 0.4 0.013 16.1 0.4 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDI75114.1 - 0.012 15.8 4.6 0.041 14.1 0.5 2.2 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 CDI75114.1 - 0.016 15.0 4.4 0.056 13.2 0.2 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 CDI75114.1 - 0.034 14.1 0.2 0.034 14.1 0.2 1.5 2 0 0 2 2 1 0 NACHT domain NTPase_1 PF03266.15 CDI75114.1 - 0.038 13.9 0.2 0.053 13.4 0.2 1.2 1 0 0 1 1 1 0 NTPase cobW PF02492.19 CDI75114.1 - 0.041 13.5 0.3 0.069 12.7 0.3 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 CDI75114.1 - 0.046 14.2 0.8 0.32 11.4 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CDI75114.1 - 0.055 13.7 1.7 0.086 13.1 0.3 1.8 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 CDI75114.1 - 0.056 14.0 0.4 0.056 14.0 0.4 2.1 1 1 1 2 2 2 0 ABC transporter DUF4614 PF15391.6 CDI75114.1 - 0.066 13.2 19.6 0.084 12.9 19.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) CCSAP PF15748.5 CDI75114.1 - 0.073 13.2 11.5 0.084 13.0 11.5 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Pex14_N PF04695.13 CDI75114.1 - 0.12 13.0 14.6 0.19 12.4 14.6 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Macoilin PF09726.9 CDI75114.1 - 0.16 10.5 14.0 0.19 10.3 14.0 1.2 1 0 0 1 1 1 0 Macoilin family PCNP PF15473.6 CDI75114.1 - 0.42 11.3 15.2 0.5 11.1 15.2 1.1 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family MID_MedPIWI PF18296.1 CDI75114.1 - 0.47 10.2 10.4 0.56 10.0 10.4 1.3 1 0 0 1 1 1 0 MID domain of medPIWI Apt1 PF10351.9 CDI75114.1 - 0.64 8.8 14.7 0.62 8.8 14.7 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Apc15p PF05841.11 CDI75114.1 - 0.76 10.6 10.5 0.95 10.3 10.5 1.3 1 0 0 1 1 1 0 Apc15p protein DUF3138 PF11336.8 CDI75114.1 - 1.3 7.6 13.8 1.5 7.4 13.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Ashwin PF15323.6 CDI75114.1 - 1.4 8.9 13.8 1.5 8.8 13.8 1.2 1 0 0 1 1 1 0 Developmental protein DUF966 PF06136.13 CDI75114.1 - 1.4 8.6 15.2 1.5 8.4 15.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) BAF1_ABF1 PF04684.13 CDI75114.1 - 1.5 7.8 14.2 1.6 7.7 14.2 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SOBP PF15279.6 CDI75114.1 - 2.3 8.7 10.4 2.6 8.6 10.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Presenilin PF01080.17 CDI75114.1 - 2.5 6.8 13.0 2.6 6.7 13.0 1.1 1 0 0 1 1 1 0 Presenilin RIFIN PF02009.16 CDI75114.1 - 3.2 7.5 8.4 3.9 7.3 8.4 1.1 1 0 0 1 1 1 0 Rifin AF-4 PF05110.13 CDI75114.1 - 3.3 5.7 25.4 4.1 5.3 25.4 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF1635 PF07795.11 CDI75114.1 - 3.7 7.3 14.6 4.6 7.0 14.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) SRP-alpha_N PF04086.13 CDI75114.1 - 4.3 7.2 13.6 4.7 7.0 13.6 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TFIIA PF03153.13 CDI75114.1 - 4.9 7.0 15.2 5.9 6.8 15.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PRP38_assoc PF12871.7 CDI75115.1 - 0.53 10.9 27.8 1.2 9.8 27.8 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term CDC45 PF02724.14 CDI75115.1 - 0.68 8.1 20.7 1.2 7.3 20.7 1.3 1 0 0 1 1 1 0 CDC45-like protein ANAPC4_WD40 PF12894.7 CDI75116.1 - 0.0047 17.2 0.0 0.11 12.8 0.0 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CDI75116.1 - 0.058 13.9 1.3 4.3 8.0 0.1 3.5 4 0 0 4 4 4 0 PQQ-like domain DUF755 PF05501.11 CDI75117.1 - 0.0016 18.7 28.6 0.0016 18.7 28.6 8.1 7 1 1 8 8 8 1 Domain of unknown function (DUF755) CP12 PF02672.15 CDI75117.1 - 0.0088 16.8 4.5 0.0088 16.8 4.5 7.2 8 1 0 8 8 8 1 CP12 domain RskA PF10099.9 CDI75117.1 - 0.013 15.8 8.6 0.013 15.8 8.6 6.9 4 2 2 6 6 6 0 Anti-sigma-K factor rskA SARAF PF06682.12 CDI75118.1 - 0.038 13.6 4.4 0.045 13.4 4.4 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis TFIIA PF03153.13 CDI75118.1 - 0.056 13.4 13.5 0.058 13.4 13.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3504 PF12012.8 CDI75118.1 - 0.12 12.3 2.6 0.17 11.8 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) Spt20 PF12090.8 CDI75118.1 - 0.2 11.2 16.8 0.24 11.0 16.8 1.2 1 0 0 1 1 1 0 Spt20 family Neur_chan_memb PF02932.16 CDI75118.1 - 0.23 11.5 2.8 0.29 11.2 2.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI75118.1 - 0.64 8.7 4.4 0.65 8.7 4.4 1.1 1 0 0 1 1 1 0 Presenilin SAE2 PF08573.10 CDI75118.1 - 1.5 10.0 9.9 2 9.6 9.9 1.2 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus SUIM_assoc PF16619.5 CDI75118.1 - 3.4 7.8 19.8 6 7.0 19.8 1.5 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 TMEM51 PF15345.6 CDI75119.1 - 0.0089 15.9 12.9 0.011 15.6 12.9 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 NCOA_u2 PF16665.5 CDI75119.1 - 0.043 14.1 4.4 0.057 13.7 4.4 1.2 1 0 0 1 1 1 0 Unstructured region on nuclear receptor coactivator protein THOC2_N PF16134.5 CDI75119.1 - 0.044 12.4 11.7 0.055 12.1 11.7 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus FTO_NTD PF12933.7 CDI75119.1 - 0.064 12.5 12.5 0.07 12.4 12.5 1.0 1 0 0 1 1 1 0 FTO catalytic domain Connexin PF00029.19 CDI75119.1 - 0.22 11.2 8.6 0.34 10.6 8.6 1.3 1 0 0 1 1 1 0 Connexin 2HCT PF03390.15 CDI75119.1 - 0.31 9.6 2.5 0.33 9.5 2.5 1.0 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family UPF0565 PF10561.9 CDI75119.1 - 0.33 10.1 11.2 0.35 10.0 11.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 MRP-S26 PF14943.6 CDI75119.1 - 0.77 9.7 15.8 1 9.3 15.8 1.1 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 EOS1 PF12326.8 CDI75119.1 - 0.82 9.6 8.7 1.2 9.1 8.7 1.2 1 0 0 1 1 1 0 N-glycosylation protein FAM60A PF15396.6 CDI75119.1 - 0.98 9.4 13.4 1.1 9.2 13.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A V_ATPase_I PF01496.19 CDI75119.1 - 1.1 7.0 17.4 1.3 6.8 17.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-3_zeta PF05091.12 CDI75119.1 - 1.3 8.0 20.6 1.8 7.4 20.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF572 PF04502.13 CDI75119.1 - 1.3 8.5 16.0 1.5 8.3 16.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Suf PF05843.14 CDI75119.1 - 1.5 8.8 25.6 1.8 8.5 25.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DDHD PF02862.17 CDI75119.1 - 2 8.6 17.0 2.5 8.2 17.0 1.1 1 0 0 1 1 1 0 DDHD domain SLC12 PF03522.15 CDI75119.1 - 2.1 7.3 18.8 2.4 7.1 18.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 CDI75119.1 - 2.9 6.6 21.7 3.3 6.4 21.7 1.0 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI75119.1 - 3 7.6 16.8 3.7 7.3 16.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2076 PF09849.9 CDI75119.1 - 3.7 7.5 36.5 4.2 7.3 36.5 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) HNOBA PF07701.14 CDI75119.1 - 3.7 6.9 22.4 0.22 10.9 15.0 1.9 1 1 1 2 2 2 0 Heme NO binding associated DUF2828 PF11443.8 CDI75119.1 - 3.7 5.5 14.6 4.4 5.3 14.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) LAP1C PF05609.12 CDI75119.1 - 3.9 6.4 22.2 4.1 6.4 22.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) TFIIA PF03153.13 CDI75119.1 - 4 7.3 50.6 4.7 7.1 50.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI75119.1 - 4.3 7.3 15.3 4.8 7.2 15.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Gti1_Pac2 PF09729.9 CDI75119.1 - 4.7 7.3 13.5 7.1 6.7 13.5 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family CAF1 PF04857.20 CDI75119.1 - 4.8 6.3 12.3 5.6 6.0 12.3 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease DUF2126 PF09899.9 CDI75119.1 - 4.8 5.1 12.6 5.7 4.9 12.6 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CSG2 PF16965.5 CDI75119.1 - 4.8 6.0 8.2 6.7 5.5 8.2 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Spore_coat_CotO PF14153.6 CDI75119.1 - 5.7 6.8 26.0 7.8 6.4 26.0 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Velvet PF11754.8 CDI75119.1 - 6.5 6.6 18.7 8 6.3 18.7 1.1 1 0 0 1 1 1 0 Velvet factor XRN_M PF17846.1 CDI75119.1 - 6.9 5.5 13.6 8.4 5.2 13.6 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Hydin_ADK PF17213.3 CDI75119.1 - 8.6 6.6 17.5 12 6.2 17.5 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain CLN3 PF02487.17 CDI75119.1 - 8.6 5.3 13.3 11 5.0 13.3 1.2 1 0 0 1 1 1 0 CLN3 protein MAJIN PF15077.6 CDI75119.1 - 9.1 6.0 12.1 10 5.8 12.1 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein MMR1 PF08505.10 CDI75119.1 - 9.5 6.4 26.4 12 6.1 26.4 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein O-antigen_lig PF13425.6 CDI75119.1 - 9.6 4.9 9.1 11 4.6 9.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Phostensin_N PF13916.6 CDI75121.1 - 0.0023 18.2 3.7 0.0023 18.2 3.7 4.4 3 1 0 3 3 3 1 PP1-regulatory protein, Phostensin N-terminal DUF1635 PF07795.11 CDI75122.1 - 0.083 12.7 1.1 0.084 12.7 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) SR-25 PF10500.9 CDI75122.1 - 0.71 9.4 17.0 0.96 9.0 17.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDK2AP PF09806.9 CDI75122.1 - 1.7 8.6 10.7 2.1 8.3 10.7 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein AF-4 PF05110.13 CDI75122.1 - 2.8 5.9 15.9 2.9 5.8 15.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TRAP_alpha PF03896.16 CDI75125.1 - 0.011 15.0 6.9 0.011 15.0 6.9 2.3 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit TCP PF03634.13 CDI75125.1 - 0.014 15.9 20.5 0.014 15.9 20.5 2.4 2 0 0 2 2 2 0 TCP family transcription factor DUF3017 PF11222.8 CDI75125.1 - 0.27 11.5 2.1 0.42 10.9 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3017) RR_TM4-6 PF06459.12 CDI75125.1 - 0.91 9.3 43.2 0.42 10.4 21.7 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Lin-8 PF03353.15 CDI75125.1 - 1.6 8.3 44.2 0.14 11.7 12.7 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF2828 PF11443.8 CDI75125.1 - 5 5.1 34.4 0.2 9.7 15.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Ribosomal_60s PF00428.19 CDI75125.1 - 5.9 7.5 25.8 0.28 11.8 10.7 3.5 2 2 1 3 3 3 0 60s Acidic ribosomal protein DUF2126 PF09899.9 CDI75125.1 - 9.4 4.2 22.5 0.72 7.9 8.8 2.2 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) DUF2362 PF10154.9 CDI75127.1 - 0.0003 19.9 0.0 0.0003 19.9 0.0 4.2 2 2 1 3 3 3 1 Uncharacterized conserved protein (DUF2362) Shisa PF13908.6 CDI75127.1 - 0.004 17.4 2.1 0.004 17.4 2.1 3.6 3 0 0 3 3 3 1 Wnt and FGF inhibitory regulator Ank_2 PF12796.7 CDI75128.1 - 8.9e-06 26.2 0.6 3.7e-05 24.2 0.1 2.3 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI75128.1 - 0.017 15.7 2.7 0.017 15.7 0.0 2.4 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI75128.1 - 0.018 15.6 2.7 0.33 11.6 0.0 3.9 5 0 0 5 5 5 0 Ankyrin repeat Methyltransf_25 PF13649.6 CDI75128.1 - 0.026 15.2 0.0 0.23 12.2 0.0 2.5 3 0 0 3 3 3 0 Methyltransferase domain Ank_5 PF13857.6 CDI75128.1 - 0.058 13.7 0.1 0.22 11.9 0.1 2.1 1 0 0 1 1 1 0 Ankyrin repeats (many copies) DENN PF02141.21 CDI75131.1 - 2.8e-19 69.8 7.4 2.8e-19 69.8 7.4 3.5 4 0 0 4 4 4 2 DENN (AEX-3) domain uDENN PF03456.18 CDI75131.1 - 3e-07 31.1 1.2 9.5e-05 23.1 0.0 3.4 2 0 0 2 2 2 2 uDENN domain DUF3450 PF11932.8 CDI75133.1 - 0.021 14.2 9.0 0.028 13.7 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) RskA PF10099.9 CDI75133.1 - 0.085 13.1 9.1 0.13 12.6 9.1 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA BAF1_ABF1 PF04684.13 CDI75133.1 - 0.32 10.0 3.4 0.33 10.0 3.4 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Fusion_gly PF00523.18 CDI75133.1 - 0.68 8.1 8.6 0.76 8.0 8.6 1.0 1 0 0 1 1 1 0 Fusion glycoprotein F0 IHABP4_N PF16174.5 CDI75133.1 - 0.83 10.2 12.0 1 9.9 12.0 1.3 1 1 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Activator_LAG-3 PF11498.8 CDI75134.1 - 0.00019 20.5 42.3 0.00019 20.5 42.3 8.0 5 1 3 8 8 8 3 Transcriptional activator LAG-3 VCBS PF13517.6 CDI75135.1 - 4.1e-23 81.7 7.7 6.9e-06 26.6 0.3 8.9 7 2 3 10 10 9 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CDI75135.1 - 2.7e-11 43.4 30.3 1.5e-05 25.0 0.2 6.8 8 0 0 8 8 6 3 FG-GAP repeat Spt20 PF12090.8 CDI75135.1 - 1.6e-06 27.9 76.8 0.0025 17.4 17.4 3.5 3 0 0 3 3 3 3 Spt20 family RskA PF10099.9 CDI75135.1 - 5.1e-06 26.9 78.3 0.00016 22.1 1.4 4.9 3 1 1 4 4 3 2 Anti-sigma-K factor rskA Med15 PF09606.10 CDI75135.1 - 7.5e-06 24.9 73.3 0.011 14.5 28.1 3.1 3 0 0 3 3 3 3 ARC105 or Med15 subunit of Mediator complex non-fungal AAA_23 PF13476.6 CDI75135.1 - 0.0045 17.5 19.4 0.49 10.9 0.0 3.4 3 0 0 3 3 3 2 AAA domain MecA PF05389.12 CDI75135.1 - 0.0061 16.2 11.8 1.4 8.5 1.6 3.5 3 0 0 3 3 3 2 Negative regulator of genetic competence (MecA) DUF3381 PF11861.8 CDI75135.1 - 0.0072 16.1 1.1 0.0072 16.1 1.1 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3381) Slu7 PF11708.8 CDI75135.1 - 0.012 15.4 22.5 0.43 10.3 0.4 3.4 3 0 0 3 3 3 0 Pre-mRNA splicing Prp18-interacting factor EPL1 PF10513.9 CDI75135.1 - 0.022 15.2 0.9 0.022 15.2 0.9 4.3 3 2 0 3 3 1 0 Enhancer of polycomb-like eIF-3_zeta PF05091.12 CDI75135.1 - 0.033 13.2 25.0 0.66 8.9 1.9 3.2 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MAT1 PF06391.13 CDI75135.1 - 0.05 13.4 34.0 0.31 10.8 1.9 3.5 3 0 0 3 3 3 0 CDK-activating kinase assembly factor MAT1 Rxt3 PF08642.10 CDI75135.1 - 0.071 13.9 21.6 0.065 14.0 1.1 4.3 3 1 1 4 4 4 0 Histone deacetylation protein Rxt3 SpoIIP PF07454.11 CDI75135.1 - 0.081 12.4 19.8 0.16 11.4 2.6 3.4 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) FmiP_Thoc5 PF09766.9 CDI75135.1 - 0.35 10.1 27.0 0.12 11.7 1.3 3.6 4 0 0 4 4 3 0 Fms-interacting protein/Thoc5 Connexin PF00029.19 CDI75135.1 - 0.37 10.5 10.7 3.9 7.2 1.5 3.2 3 0 0 3 3 3 0 Connexin RPA43_OB PF17875.1 CDI75135.1 - 0.49 11.0 14.9 3.8 8.2 1.5 3.9 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I RR_TM4-6 PF06459.12 CDI75135.1 - 0.59 9.9 17.9 1.1 9.0 3.4 3.5 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 EF-hand_1 PF00036.32 CDI75135.1 - 0.83 9.4 12.4 2.5 7.9 0.2 4.5 5 0 0 5 5 5 0 EF hand Peptidase_S49_N PF08496.10 CDI75135.1 - 0.89 9.6 18.0 6.2 6.9 1.5 3.3 3 0 0 3 3 3 0 Peptidase family S49 N-terminal Spore_coat_CotO PF14153.6 CDI75135.1 - 1.2 9.1 38.7 0.21 11.5 0.8 3.4 3 0 0 3 3 3 0 Spore coat protein CotO TATR PF03430.13 CDI75135.1 - 1.5 7.1 6.5 3.1 6.1 6.5 1.4 1 0 0 1 1 1 0 Trans-activating transcriptional regulator Pet20 PF08692.10 CDI75135.1 - 2.2 9.0 11.8 25 5.6 0.5 3.6 3 0 0 3 3 3 0 Mitochondrial protein Pet20 XRN_M PF17846.1 CDI75135.1 - 2.6 6.9 11.6 7.1 5.5 0.7 3.2 3 0 0 3 3 3 0 Xrn1 helical domain EF-hand_5 PF13202.6 CDI75135.1 - 2.8 7.6 10.3 4.2 7.0 0.2 3.7 4 0 0 4 4 3 0 EF hand EF-hand_6 PF13405.6 CDI75135.1 - 3.3 7.9 9.9 26 5.1 0.2 4.0 4 0 0 4 4 3 0 EF-hand domain DUF4179 PF13786.6 CDI75135.1 - 3.6 8.1 0.0 3.6 8.1 0.0 5.5 3 1 1 4 4 3 0 Domain of unknown function (DUF4179) PRP1_N PF06424.12 CDI75135.1 - 3.6 8.0 24.7 1.6 9.2 3.9 3.6 3 0 0 3 3 3 0 PRP1 splicing factor, N-terminal TFIIA PF03153.13 CDI75135.1 - 5.2 7.0 106.3 0.12 12.4 23.1 3.6 1 1 2 3 3 2 0 Transcription factor IIA, alpha/beta subunit Otopetrin PF03189.13 CDI75135.1 - 5.6 5.7 13.6 6.3e+02 -1.1 13.8 2.6 1 1 0 1 1 1 0 Otopetrin Thg1C PF14413.6 CDI75135.1 - 6 7.0 24.4 4.4 7.5 6.0 3.4 3 0 0 3 3 3 0 Thg1 C terminal domain Usp PF00582.26 CDI75135.1 - 8.4 6.9 0.0 1.2 9.6 1.6 4.7 4 1 0 4 4 3 0 Universal stress protein family G0-G1_switch_2 PF15103.6 CDI75135.1 - 8.6 6.8 21.4 7.2 7.1 1.6 3.7 3 0 0 3 3 3 0 G0/G1 switch protein 2 DUF4820 PF16091.5 CDI75136.1 - 0.00012 21.5 9.4 0.082 12.3 5.1 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4820) FAM176 PF14851.6 CDI75136.1 - 0.0021 17.7 7.0 0.01 15.5 1.7 2.5 2 0 0 2 2 2 1 FAM176 family RskA PF10099.9 CDI75136.1 - 0.0073 16.6 21.3 0.0073 16.6 21.3 4.6 1 1 2 3 3 2 1 Anti-sigma-K factor rskA TMEM208_SND2 PF05620.11 CDI75136.1 - 0.094 12.5 2.2 0.19 11.5 0.7 2.2 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 CSG2 PF16965.5 CDI75136.1 - 0.23 10.4 10.1 0.06 12.3 6.8 1.6 1 1 1 2 2 2 0 Ceramide synthase regulator O-antigen_lig PF13425.6 CDI75136.1 - 0.24 10.2 2.3 0.43 9.3 2.3 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein V_ATPase_I PF01496.19 CDI75136.1 - 0.26 9.2 12.5 0.13 10.2 7.2 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family SID-1_RNA_chan PF13965.6 CDI75136.1 - 0.76 8.1 10.0 0.34 9.3 6.2 1.9 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 TRAP_alpha PF03896.16 CDI75136.1 - 0.77 8.9 9.8 0.054 12.7 3.0 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Connexin PF00029.19 CDI75136.1 - 1.2 8.8 12.5 4.3 7.0 7.7 2.2 1 1 0 2 2 2 0 Connexin DUF2232 PF09991.9 CDI75136.1 - 1.3 8.1 3.5 3.2 6.8 2.2 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) DUF572 PF04502.13 CDI75136.1 - 3.7 7.1 17.6 7.7 6.0 17.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF572) Utp14 PF04615.13 CDI75136.1 - 4.3 5.8 26.9 0.15 10.6 21.0 1.5 2 0 0 2 2 2 0 Utp14 protein 60KD_IMP PF02096.20 CDI75136.1 - 6 6.7 9.0 27 4.6 0.0 2.2 2 0 0 2 2 2 0 60Kd inner membrane protein DUF3381 PF11861.8 CDI75136.1 - 7.6 6.3 24.3 4.7 7.0 1.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) DUF4834 PF16118.5 CDI75136.1 - 9.4 7.3 23.0 60 4.7 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) ANAPC_CDC26 PF10471.9 CDI75137.1 - 0.0063 17.3 42.9 0.45 11.4 4.4 3.2 3 0 0 3 3 3 3 Anaphase-promoting complex APC subunit CDC26 CAAD PF14159.6 CDI75137.1 - 0.018 14.9 5.2 0.2 11.5 0.1 2.7 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase LPMO_10 PF03067.15 CDI75137.1 - 0.024 15.3 5.9 0.12 13.0 5.9 1.9 1 1 0 1 1 1 0 Lytic polysaccharide mono-oxygenase, cellulose-degrading Toxin_R_bind_C PF07951.12 CDI75137.1 - 0.14 11.8 1.3 12 5.5 0.1 2.2 1 1 1 2 2 2 0 Clostridium neurotoxin, C-terminal receptor binding GAGA_bind PF06217.12 CDI75137.1 - 1.3 9.3 15.3 1.8 8.8 15.3 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family CDT1_C PF16679.5 CDI75137.1 - 3 8.3 33.3 1.1 9.7 5.2 3.3 3 0 0 3 3 3 0 DNA replication factor Cdt1 C-terminal domain MRP-S31 PF15433.6 CDI75137.1 - 5.9 6.5 19.0 7.4 6.1 19.0 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Band_3_cyto PF07565.13 CDI75137.1 - 9.3 6.0 22.8 0.19 11.5 12.9 2.0 1 1 1 2 2 2 0 Band 3 cytoplasmic domain EF_TS PF00889.19 CDI75138.1 - 1.9e-26 93.0 11.6 3.8e-21 75.7 3.6 3.1 2 1 0 2 2 2 2 Elongation factor TS Spt20 PF12090.8 CDI75138.1 - 0.0016 18.1 10.1 0.0016 18.1 10.1 2.3 2 0 0 2 2 2 1 Spt20 family AP3D1 PF06375.11 CDI75138.1 - 2.1 8.6 12.4 5.5 7.2 12.4 1.7 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF1645 PF07816.11 CDI75138.1 - 3 8.4 19.0 0.14 12.7 11.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) DAG_kinase_N PF14513.6 CDI75138.1 - 3.5 7.8 13.1 0.97 9.6 7.8 2.3 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus CDT1_C PF16679.5 CDI75138.1 - 6.6 7.2 13.8 1.8 9.1 5.3 2.9 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain DUF3446 PF11928.8 CDI75139.1 - 0.0094 16.2 20.8 0.16 12.3 9.2 3.3 3 0 0 3 3 3 2 Early growth response N-terminal domain Apt1 PF10351.9 CDI75139.1 - 0.15 10.9 5.8 0.14 11.0 5.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain RAP1 PF07218.11 CDI75139.1 - 3.8 5.7 11.9 4.7 5.4 11.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Hid1 PF12722.7 CDI75139.1 - 4.7 5.2 8.4 5.5 5.0 8.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Spt20 PF12090.8 CDI75140.1 - 0.0027 17.4 3.8 0.0027 17.4 3.8 10.6 10 0 0 10 10 10 5 Spt20 family SUIM_assoc PF16619.5 CDI75140.1 - 0.0064 16.5 2.1 0.0064 16.5 2.1 17.6 12 7 4 16 16 16 1 Unstructured region C-term to UIM in Ataxin3 SpoIIIAH PF12685.7 CDI75140.1 - 0.031 14.1 87.2 0.16 11.7 3.4 8.4 6 1 0 7 7 7 0 SpoIIIAH-like protein Lin-8 PF03353.15 CDI75140.1 - 0.4 10.2 93.7 0.14 11.7 9.5 7.3 7 0 0 7 7 7 0 Ras-mediated vulval-induction antagonist Tetraspanin PF00335.20 CDI75141.1 - 0.07 12.8 0.0 24 4.5 0.0 4.2 2 2 0 3 3 3 0 Tetraspanin family DUF3446 PF11928.8 CDI75142.1 - 0.037 14.3 10.2 0.22 11.9 10.2 2.4 1 0 0 1 1 1 0 Early growth response N-terminal domain DDRGK PF09756.9 CDI75143.1 - 0.0056 16.3 17.5 0.0056 16.3 17.5 2.1 2 0 0 2 2 2 1 DDRGK domain RskA PF10099.9 CDI75143.1 - 0.0074 16.6 5.2 0.0074 16.6 5.2 2.9 1 1 1 2 2 2 1 Anti-sigma-K factor rskA SSP160 PF06933.11 CDI75143.1 - 0.048 11.9 24.3 0.061 11.5 24.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 SPX PF03105.19 CDI75143.1 - 0.56 10.1 35.8 0.88 9.4 35.8 1.2 1 0 0 1 1 1 0 SPX domain BUD22 PF09073.10 CDI75143.1 - 0.81 9.0 33.3 0.93 8.8 33.3 1.0 1 0 0 1 1 1 0 BUD22 Pinin_SDK_memA PF04696.13 CDI75143.1 - 3 7.9 40.7 2 8.5 30.1 2.3 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Pex14_N PF04695.13 CDI75143.1 - 8.6 7.0 61.5 1.4 9.5 28.9 2.1 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ACDC PF14733.6 CDI75144.1 - 8.8e-25 86.9 0.2 2.4e-24 85.4 0.2 1.8 1 0 0 1 1 1 1 AP2-coincident C-terminal AP2 PF00847.20 CDI75144.1 - 5e-06 26.7 5.0 5e-06 26.7 5.0 2.2 2 0 0 2 2 2 1 AP2 domain SUIM_assoc PF16619.5 CDI75144.1 - 0.003 17.6 3.3 0.003 17.6 3.3 2.8 3 0 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 Euplotes_phero PF05842.11 CDI75144.1 - 0.89 10.1 4.1 34 5.0 0.0 3.8 4 0 0 4 4 4 0 Euplotes octocarinatus mating pheromone protein DUF3408 PF11888.8 CDI75144.1 - 1.6 8.8 4.2 3.4 7.8 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) DUF572 PF04502.13 CDI75146.1 - 0.61 9.6 14.6 0.9 9.1 14.6 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF572) DUF3292 PF11696.8 CDI75146.1 - 0.72 8.2 3.2 1 7.7 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DnaJ PF00226.31 CDI75147.1 - 6.9e-10 38.9 0.0 1.8e-09 37.6 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain PITH PF06201.13 CDI75149.1 - 5.9e-17 62.3 0.0 9.5e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 PITH domain EIIBC-GUT_N PF03612.14 CDI75151.1 - 0.00056 19.7 7.1 1.4 8.6 0.1 3.3 3 0 0 3 3 3 3 Sorbitol phosphotransferase enzyme II N-terminus Trp_oprn_chp PF09534.10 CDI75151.1 - 0.0012 18.7 3.4 1.5 8.6 2.9 3.1 3 0 0 3 3 3 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) YjeF_N PF03853.15 CDI75151.1 - 0.0033 17.4 0.3 2.6 7.9 0.0 2.7 3 0 0 3 3 3 2 YjeF-related protein N-terminus GEN1_C PF18380.1 CDI75151.1 - 0.018 15.9 10.3 1.2 10.0 0.6 3.2 3 0 0 3 3 3 0 Holliday junction resolvase Gen1 C-terminal domain FAM176 PF14851.6 CDI75151.1 - 0.44 10.2 21.0 0.45 10.2 3.0 3.3 3 0 0 3 3 3 0 FAM176 family PepSY_2 PF13670.6 CDI75151.1 - 1.4 9.0 5.1 4.2 7.4 5.1 1.8 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain Tir_receptor_N PF07490.11 CDI75151.1 - 4.8 6.9 15.9 1.8 8.3 3.0 2.3 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) N-terminus Vfa1 PF08432.10 CDI75151.1 - 9.7 6.5 23.6 2.7 8.3 2.2 3.3 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 CDI75152.1 - 0.0011 18.9 25.9 0.0012 18.7 25.9 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 DUF2052 PF09747.9 CDI75152.1 - 0.0052 16.9 18.1 0.0053 16.9 18.1 1.1 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) PAT1 PF09770.9 CDI75152.1 - 0.013 13.8 38.6 0.014 13.7 38.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CCSAP PF15748.5 CDI75152.1 - 0.026 14.7 27.4 0.028 14.6 27.4 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Med15 PF09606.10 CDI75152.1 - 0.027 13.2 45.2 0.033 12.9 45.2 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SID-1_RNA_chan PF13965.6 CDI75152.1 - 0.035 12.5 7.7 0.044 12.2 7.7 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 eIF-3_zeta PF05091.12 CDI75152.1 - 0.11 11.5 30.0 0.13 11.2 30.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SARAF PF06682.12 CDI75152.1 - 0.11 12.2 16.3 0.13 11.9 16.3 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis TCP PF03634.13 CDI75152.1 - 0.12 12.9 26.2 0.15 12.6 26.2 1.3 1 0 0 1 1 1 0 TCP family transcription factor Neur_chan_memb PF02932.16 CDI75152.1 - 0.13 12.3 18.0 0.14 12.2 18.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2828 PF11443.8 CDI75152.1 - 0.14 10.2 23.3 0.16 10.1 23.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) RIFIN PF02009.16 CDI75152.1 - 0.18 11.7 23.4 0.22 11.4 23.4 1.1 1 0 0 1 1 1 0 Rifin SelP_N PF04592.14 CDI75152.1 - 0.24 10.8 34.9 0.3 10.4 34.9 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Velvet PF11754.8 CDI75152.1 - 0.25 11.3 20.3 0.3 11.0 20.3 1.3 1 0 0 1 1 1 0 Velvet factor SAPS PF04499.15 CDI75152.1 - 0.27 9.9 17.8 0.27 10.0 17.8 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 CDI75152.1 - 0.28 9.4 24.5 0.33 9.2 24.5 1.1 1 0 0 1 1 1 0 CDC45-like protein BORG_CEP PF14957.6 CDI75152.1 - 0.34 12.1 15.5 0.47 11.6 15.5 1.3 1 0 0 1 1 1 0 Cdc42 effector Paramyxo_ncap PF00973.19 CDI75152.1 - 0.36 9.7 19.0 0.42 9.5 19.0 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF913 PF06025.12 CDI75152.1 - 0.42 9.5 15.2 0.53 9.2 15.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) O-antigen_lig PF13425.6 CDI75152.1 - 0.48 9.2 9.3 0.52 9.1 9.3 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4045 PF13254.6 CDI75152.1 - 0.51 9.9 24.0 0.56 9.8 24.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF3568 PF12092.8 CDI75152.1 - 0.51 10.4 9.0 0.2 11.7 6.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3568) SLC12 PF03522.15 CDI75152.1 - 0.54 9.2 28.1 0.64 9.0 28.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 CDI75152.1 - 0.56 10.2 25.6 0.73 9.8 25.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Nop53 PF07767.11 CDI75152.1 - 0.63 9.4 40.3 0.72 9.2 40.3 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Otopetrin PF03189.13 CDI75152.1 - 0.75 8.5 14.8 0.91 8.3 14.8 1.2 1 0 0 1 1 1 0 Otopetrin Asp-B-Hydro_N PF05279.11 CDI75152.1 - 1 9.4 20.7 1.1 9.3 20.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region AMP-binding PF00501.28 CDI75152.1 - 1.1 7.8 7.0 1.3 7.5 7.0 1.2 1 0 0 1 1 1 0 AMP-binding enzyme Vac7 PF12751.7 CDI75152.1 - 1.1 8.6 16.8 1.3 8.4 16.8 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 PIEZO PF15917.5 CDI75152.1 - 2 7.9 30.8 2.9 7.3 30.8 1.3 1 0 0 1 1 1 0 Piezo GREB1 PF15782.5 CDI75152.1 - 2.3 5.2 25.8 2.5 5.1 25.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Endostatin PF06482.11 CDI75152.1 - 4.2 6.7 26.8 5.1 6.5 26.8 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Tim54 PF11711.8 CDI75152.1 - 4.3 6.0 25.2 6.3 5.5 25.2 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4569 PF15133.6 CDI75152.1 - 5.6 6.6 30.4 7.3 6.2 30.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) AAA_11 PF13086.6 CDI75152.1 - 6.1 6.5 26.6 7.6 6.2 26.6 1.1 1 0 0 1 1 1 0 AAA domain HCO3_cotransp PF00955.21 CDI75152.1 - 7.4 5.3 12.1 8.3 5.1 12.1 1.1 1 0 0 1 1 1 0 HCO3- transporter family Gti1_Pac2 PF09729.9 CDI75152.1 - 9.4 6.3 27.4 13 5.8 27.4 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Spore_coat_CotO PF14153.6 CDI75152.1 - 9.6 6.1 36.2 13 5.7 36.2 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Lin-8 PF03353.15 CDI75152.1 - 9.8 5.6 31.6 12 5.3 31.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RskA PF10099.9 CDI75153.1 - 4.4e-08 33.6 0.0 4.4e-08 33.6 0.0 8.0 4 3 2 7 7 7 3 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI75153.1 - 0.011 16.7 46.7 0.28 12.2 2.6 6.5 6 0 0 6 6 6 0 Domain of unknown function (DUF4834) SPX PF03105.19 CDI75153.1 - 0.53 10.1 37.6 0.99 9.3 2.5 4.2 4 0 0 4 4 4 0 SPX domain DUF2722 PF10846.8 CDI75154.1 - 0.00052 19.1 13.3 0.00052 19.1 13.3 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF2722) Suf PF05843.14 CDI75154.1 - 0.0016 18.5 8.0 0.0016 18.5 8.0 2.1 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) AAA_23 PF13476.6 CDI75154.1 - 0.0061 17.1 5.6 0.0061 17.1 5.6 2.0 2 0 0 2 2 2 1 AAA domain RskA PF10099.9 CDI75154.1 - 0.012 15.9 20.0 0.012 15.9 20.0 4.0 2 1 2 4 4 4 0 Anti-sigma-K factor rskA CTNNB1_binding PF08347.11 CDI75154.1 - 0.014 15.6 1.1 0.014 15.6 1.1 2.1 2 1 0 2 2 2 0 N-terminal CTNNB1 binding PIP5K PF01504.18 CDI75154.1 - 0.022 14.0 2.6 0.16 11.2 0.2 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase ANAPC_CDC26 PF10471.9 CDI75154.1 - 0.045 14.6 17.3 0.045 14.6 17.3 3.9 3 1 0 3 3 2 0 Anaphase-promoting complex APC subunit CDC26 LMBR1 PF04791.16 CDI75154.1 - 0.059 12.3 0.1 0.062 12.2 0.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein MDM31_MDM32 PF08118.11 CDI75154.1 - 0.091 11.4 3.7 0.21 10.2 3.7 1.6 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins MMR1 PF08505.10 CDI75154.1 - 0.14 12.5 11.6 0.089 13.1 5.8 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Spt20 PF12090.8 CDI75154.1 - 0.26 10.9 34.1 0.093 12.3 25.9 2.5 2 0 0 2 2 2 0 Spt20 family GNAT_acetyltr_2 PF13718.6 CDI75154.1 - 0.46 9.8 5.2 0.29 10.5 2.4 1.9 2 0 0 2 2 2 0 GNAT acetyltransferase 2 DUF1676 PF07898.13 CDI75154.1 - 0.71 9.9 3.3 3.1 7.8 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Peptidase_S66 PF02016.15 CDI75154.1 - 1.2 9.2 4.6 0.65 10.1 1.5 2.2 1 1 1 2 2 2 0 LD-carboxypeptidase N-terminal domain Gti1_Pac2 PF09729.9 CDI75154.1 - 1.5 8.9 7.0 0.49 10.4 0.4 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family Nse4_C PF08743.10 CDI75154.1 - 2 8.7 8.6 1.1 9.6 4.4 2.4 2 0 0 2 2 2 0 Nse4 C-terminal Utp14 PF04615.13 CDI75154.1 - 2.6 6.5 25.4 3.4 6.1 25.4 1.1 1 0 0 1 1 1 0 Utp14 protein Peptidase_S49_N PF08496.10 CDI75154.1 - 3.7 7.6 15.6 0.17 11.9 6.6 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Ctr PF04145.15 CDI75154.1 - 3.9 8.1 5.1 2 9.0 0.9 2.3 2 0 0 2 2 2 0 Ctr copper transporter family DUF702 PF05142.12 CDI75154.1 - 4.1 7.9 11.8 1.2 9.6 4.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF702) TMEM247 PF15444.6 CDI75154.1 - 6.6 6.7 9.8 0.89 9.6 2.8 2.3 2 0 0 2 2 2 0 Transmembrane protein 247 SMYLE_N PF18615.1 CDI75154.1 - 7.5 6.0 12.2 0.53 9.8 4.0 2.1 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain NPF PF16601.5 CDI75156.1 - 0.024 15.1 2.7 0.026 15.0 2.7 1.1 1 0 0 1 1 1 0 Rabosyn-5 repeating NPF sequence-motif Peptidase_U57 PF05582.12 CDI75156.1 - 0.038 13.3 0.4 0.045 13.0 0.4 1.0 1 0 0 1 1 1 0 YabG peptidase U57 DUF2722 PF10846.8 CDI75156.1 - 0.081 11.9 11.0 0.098 11.6 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spore_coat_CotO PF14153.6 CDI75156.1 - 0.22 11.4 7.2 0.26 11.2 7.2 1.0 1 0 0 1 1 1 0 Spore coat protein CotO Kei1 PF08552.11 CDI75156.1 - 0.3 10.9 2.7 0.36 10.7 2.7 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Suf PF05843.14 CDI75156.1 - 0.32 10.9 4.6 0.34 10.9 4.6 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RskA PF10099.9 CDI75156.1 - 0.35 11.1 14.2 0.41 10.9 14.2 1.0 1 0 0 1 1 1 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI75156.1 - 0.47 10.4 15.8 0.53 10.2 15.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI75156.1 - 0.87 9.2 16.7 0.96 9.0 16.7 1.1 1 0 0 1 1 1 0 Spt20 family OmpH PF03938.14 CDI75156.1 - 1.4 9.2 17.1 1.8 8.9 17.1 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Presenilin PF01080.17 CDI75156.1 - 2.1 7.0 4.9 2.2 7.0 4.9 1.1 1 0 0 1 1 1 0 Presenilin Activator_LAG-3 PF11498.8 CDI75156.1 - 2.7 6.9 19.4 3 6.7 19.4 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Androgen_recep PF02166.16 CDI75156.1 - 7.5 5.3 21.9 12 4.6 21.9 1.3 1 1 0 1 1 1 0 Androgen receptor Med3 PF11593.8 CDI75156.1 - 8.9 5.4 18.2 14 4.8 18.2 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DivIC PF04977.15 CDI75156.1 - 9.1 6.1 14.0 42 4.0 11.2 2.2 2 0 0 2 2 2 0 Septum formation initiator SNase PF00565.17 CDI75158.1 - 5.3e-11 42.9 0.2 0.003 18.0 0.0 4.9 4 1 0 4 4 4 3 Staphylococcal nuclease homologue DUF1952 PF09189.10 CDI75158.1 - 0.043 13.7 0.1 0.18 11.7 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1952) Lin-8 PF03353.15 CDI75159.1 - 0.0056 16.3 24.1 0.0072 15.9 24.1 1.2 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist Caldesmon PF02029.15 CDI75159.1 - 0.086 11.6 26.0 0.1 11.3 26.0 1.0 1 0 0 1 1 1 0 Caldesmon Presenilin PF01080.17 CDI75159.1 - 0.2 10.3 29.5 0.25 10.1 29.5 1.1 1 0 0 1 1 1 0 Presenilin DUF4045 PF13254.6 CDI75159.1 - 0.46 10.1 24.8 0.6 9.7 24.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) FAM60A PF15396.6 CDI75159.1 - 0.62 10.0 19.3 0.87 9.5 19.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Pkinase_fungal PF17667.1 CDI75159.1 - 0.65 8.7 14.2 0.91 8.2 14.2 1.2 1 0 0 1 1 1 0 Fungal protein kinase DUF572 PF04502.13 CDI75159.1 - 0.93 9.0 22.9 1.2 8.7 22.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Sin_N PF04801.13 CDI75159.1 - 1.2 8.3 36.5 1.6 7.9 36.5 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region Rgp1 PF08737.10 CDI75159.1 - 1.8 7.6 24.0 2.3 7.3 24.0 1.1 1 0 0 1 1 1 0 Rgp1 DUF4175 PF13779.6 CDI75159.1 - 1.9 6.3 48.7 2.3 6.0 48.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Hydin_ADK PF17213.3 CDI75159.1 - 2.3 8.4 28.7 4 7.7 28.7 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain GREB1 PF15782.5 CDI75159.1 - 4.8 4.2 30.2 5.5 4.0 30.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ALMT PF11744.8 CDI75159.1 - 7 5.3 22.6 9 5.0 22.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Asp-B-Hydro_N PF05279.11 CDI75159.1 - 8.8 6.3 24.4 11 6.0 24.4 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Band_3_cyto PF07565.13 CDI75159.1 - 8.9 6.0 28.5 14 5.3 28.5 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Ank_2 PF12796.7 CDI75160.1 - 1.4e-12 48.0 3.0 2.5e-11 44.0 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Methyltransf_16 PF10294.9 CDI75160.1 - 3.7e-12 46.3 0.0 8.5e-11 41.9 0.0 2.5 1 1 0 1 1 1 1 Lysine methyltransferase Ank_4 PF13637.6 CDI75160.1 - 5.2e-10 39.7 3.9 2.9e-06 27.7 0.1 3.7 2 2 2 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDI75160.1 - 1.4e-09 38.0 3.9 8.2e-08 32.4 0.4 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 CDI75160.1 - 1.5e-09 37.8 0.5 0.00029 21.2 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 CDI75160.1 - 6.1e-09 35.4 0.5 0.00036 20.8 0.1 4.1 3 0 0 3 3 3 2 Ankyrin repeat Methyltransf_23 PF13489.6 CDI75160.1 - 1.3e-05 25.1 0.1 1.3e-05 25.1 0.1 3.1 2 1 1 3 3 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI75160.1 - 0.0074 17.0 0.0 0.0074 17.0 0.0 3.8 3 1 0 3 3 3 1 Methyltransferase domain SR-25 PF10500.9 CDI75160.1 - 0.0075 15.9 11.5 0.0075 15.9 11.5 3.0 4 0 0 4 4 4 1 Nuclear RNA-splicing-associated protein Pex14_N PF04695.13 CDI75160.1 - 0.014 16.1 21.0 0.014 16.1 21.0 4.4 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FGE-sulfatase PF03781.16 CDI75160.1 - 0.1 12.1 0.2 0.1 12.1 0.2 2.5 2 0 0 2 2 2 0 Sulfatase-modifying factor enzyme 1 DUF4350 PF14258.6 CDI75160.1 - 0.11 12.9 2.0 7.1 7.1 0.0 4.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4350) Ureide_permease PF07168.11 CDI75160.1 - 0.2 10.4 9.5 0.021 13.6 4.1 2.1 2 0 0 2 2 2 0 Ureide permease DUF4179 PF13786.6 CDI75160.1 - 0.34 11.4 23.9 0.63 10.6 1.6 5.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4179) Ribosomal_60s PF00428.19 CDI75160.1 - 0.96 10.1 67.6 0.039 14.5 5.7 4.8 4 0 0 4 4 4 0 60s Acidic ribosomal protein Connexin PF00029.19 CDI75160.1 - 2.5 7.8 15.6 0.064 13.0 5.3 2.8 3 0 0 3 3 3 0 Connexin SID-1_RNA_chan PF13965.6 CDI75160.1 - 5.4 5.3 8.2 0.27 9.6 2.3 1.8 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF1765 PF08578.10 CDI75161.1 - 1.3e-14 54.7 0.8 2.7e-14 53.7 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) SARAF PF06682.12 CDI75161.1 - 0.018 14.7 0.4 0.018 14.7 0.4 8.8 6 2 2 9 9 9 0 SOCE-associated regulatory factor of calcium homoeostasis F-box-like PF12937.7 CDI75162.1 - 1.2e-07 31.5 0.0 3.7e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CDI75162.1 - 0.00017 21.4 0.0 0.00096 19.0 0.0 2.2 2 0 0 2 2 2 1 F-box domain Spt20 PF12090.8 CDI75164.1 - 0.0026 17.4 39.1 0.015 15.0 13.5 3.1 3 0 0 3 3 3 2 Spt20 family EIF4E-T PF10477.9 CDI75164.1 - 0.33 9.7 15.0 0.92 8.3 0.4 2.2 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Pkinase_fungal PF17667.1 CDI75164.1 - 2 7.1 6.0 1.9 7.2 1.5 2.2 2 0 0 2 2 2 0 Fungal protein kinase Mit_KHE1 PF10173.9 CDI75164.1 - 4.5 7.3 7.7 8.2 6.5 1.3 2.7 3 0 0 3 3 3 0 Mitochondrial K+-H+ exchange-related ANAPC_CDC26 PF10471.9 CDI75164.1 - 5.4 7.9 43.9 0.87 10.5 10.3 4.5 4 1 0 4 4 4 0 Anaphase-promoting complex APC subunit CDC26 Cwf_Cwc_15 PF04889.12 CDI75165.1 - 0.1 12.3 35.9 0.16 11.7 35.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SR-25 PF10500.9 CDI75165.1 - 0.35 10.5 58.1 1.1 8.8 46.3 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein HSD3 PF15244.6 CDI75165.1 - 0.55 9.7 32.7 0.8 9.1 32.7 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 DUF4813 PF16072.5 CDI75165.1 - 0.93 9.1 18.2 2.4 7.8 4.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4813) GREB1 PF15782.5 CDI75165.1 - 1.3 6.1 33.1 1.8 5.5 33.1 1.4 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SPX PF03105.19 CDI75165.1 - 3.4 7.5 35.5 4.6 7.1 35.5 1.2 1 0 0 1 1 1 0 SPX domain Nucleo_P87 PF07267.11 CDI75165.1 - 7.3 5.3 24.8 9.7 4.9 24.8 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CCSAP PF15748.5 CDI75166.1 - 0.39 10.9 38.2 0.44 10.7 38.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Tim54 PF11711.8 CDI75166.1 - 4.7 5.9 27.7 6.2 5.5 27.7 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2126 PF09899.9 CDI75166.1 - 5.9 4.8 22.5 6.8 4.6 22.5 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) RR_TM4-6 PF06459.12 CDI75166.1 - 7.9 6.2 37.1 9.8 5.9 37.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Kinesin PF00225.23 CDI75167.1 - 1.5e-86 290.3 4.1 1.5e-43 149.1 0.0 3.2 2 1 1 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 CDI75167.1 - 1.4e-20 73.8 0.2 7.8e-20 71.3 0.2 2.4 1 1 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.5 CDI75167.1 - 2.8e-06 27.6 10.0 4.6e-05 23.6 0.2 3.5 2 1 1 3 3 3 2 Kinesin-associated FHA PF00498.26 CDI75167.1 - 0.0043 17.4 0.0 0.012 15.9 0.0 1.8 1 0 0 1 1 1 1 FHA domain DUF2015 PF09435.10 CDI75167.1 - 0.23 11.3 1.2 0.54 10.1 1.2 1.6 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2015) DUF1664 PF07889.12 CDI75167.1 - 0.68 10.0 12.8 0.47 10.5 7.9 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) AAA_13 PF13166.6 CDI75167.1 - 8.2 4.9 24.6 7.3 5.1 15.7 2.4 2 0 0 2 2 2 0 AAA domain RskA PF10099.9 CDI75169.1 - 0.00024 21.4 21.7 0.022 15.1 19.9 2.2 2 0 0 2 2 2 2 Anti-sigma-K factor rskA DUF4179 PF13786.6 CDI75169.1 - 0.0015 19.0 3.4 0.13 12.8 1.7 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4179) AAA_23 PF13476.6 CDI75169.1 - 0.0064 17.0 7.9 0.0082 16.7 7.9 1.1 1 0 0 1 1 1 1 AAA domain Oxysterol_BP PF01237.18 CDI75169.1 - 0.15 10.8 9.5 0.17 10.7 9.5 1.1 1 0 0 1 1 1 0 Oxysterol-binding protein Spt20 PF12090.8 CDI75169.1 - 0.27 10.8 46.5 0.18 11.4 6.3 2.2 2 0 0 2 2 2 0 Spt20 family SpoIIIAH PF12685.7 CDI75169.1 - 1.1 9.1 19.6 1.5 8.6 19.6 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Ribosomal_60s PF00428.19 CDI75169.1 - 2.7 8.7 13.9 7.9 7.1 13.9 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein OmpH PF03938.14 CDI75169.1 - 3.2 8.1 35.9 0.77 10.1 29.9 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Myc_N PF01056.18 CDI75169.1 - 4.2 7.2 19.4 5.9 6.7 18.9 1.5 1 1 0 1 1 1 0 Myc amino-terminal region DUF2232 PF09991.9 CDI75169.1 - 4.6 6.3 9.1 2.9 7.0 4.3 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) DUF4834 PF16118.5 CDI75169.1 - 7.1 7.7 21.3 9.9 7.2 12.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) ADP_ribosyl_GH PF03747.14 CDI75169.1 - 8.5 6.0 14.4 12 5.5 14.2 1.5 1 1 0 1 1 1 0 ADP-ribosylglycohydrolase IMUP PF15761.5 CDI75169.1 - 9.5 7.0 31.7 0.064 13.9 10.1 3.0 3 1 0 3 3 3 0 Immortalisation up-regulated protein Herpes_glycop PF01528.16 CDI75169.1 - 9.7 4.9 7.3 0.68 8.7 2.3 1.5 2 0 0 2 2 2 0 Herpesvirus glycoprotein M NicO PF03824.16 CDI75170.1 - 0.0089 15.4 4.7 0.013 14.9 4.7 1.2 1 0 0 1 1 1 1 High-affinity nickel-transport protein DUF572 PF04502.13 CDI75170.1 - 0.028 14.0 15.8 0.031 13.9 15.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Spt20 PF12090.8 CDI75170.1 - 0.074 12.7 49.9 0.07 12.7 27.0 2.1 2 0 0 2 2 2 0 Spt20 family Rft-1 PF04506.13 CDI75170.1 - 0.55 8.9 1.7 0.67 8.6 1.7 1.1 1 0 0 1 1 1 0 Rft protein Hamartin PF04388.12 CDI75170.1 - 0.64 8.6 15.2 0.75 8.4 15.2 1.3 1 0 0 1 1 1 0 Hamartin protein Draxin PF15550.6 CDI75170.1 - 0.83 9.5 22.2 0.95 9.3 22.2 1.0 1 0 0 1 1 1 0 Draxin Abhydrolase_9_N PF15420.6 CDI75170.1 - 3.4 7.6 16.7 5.6 6.9 16.7 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus SID-1_RNA_chan PF13965.6 CDI75170.1 - 3.5 5.9 11.7 7 4.9 11.7 1.5 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 DDE_Tnp_IS1595 PF12762.7 CDI75170.1 - 4 7.4 12.5 3 7.8 11.1 1.4 1 1 0 1 1 1 0 ISXO2-like transposase domain DUF4834 PF16118.5 CDI75170.1 - 5.1 8.1 23.8 2.4 9.2 9.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) SPX PF03105.19 CDI75170.1 - 5.3 6.9 18.7 6.9 6.5 18.7 1.2 1 0 0 1 1 1 0 SPX domain GREB1 PF15782.5 CDI75170.1 - 8.4 3.4 25.6 9.4 3.2 25.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RPOL_N PF14700.6 CDI75171.1 - 0.00097 18.6 14.0 0.0011 18.5 14.0 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal Zip PF02535.22 CDI75171.1 - 0.0027 17.0 14.4 0.0032 16.8 14.4 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter SprA-related PF12118.8 CDI75171.1 - 0.0045 16.2 30.6 0.0053 16.0 30.6 1.0 1 0 0 1 1 1 1 SprA-related family Peptidase_S49_N PF08496.10 CDI75171.1 - 0.0045 17.1 9.5 0.0056 16.7 9.5 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal VIT1 PF01988.19 CDI75171.1 - 0.0058 16.5 4.4 0.0071 16.2 4.4 1.1 1 0 0 1 1 1 1 VIT family Macoilin PF09726.9 CDI75171.1 - 0.01 14.4 19.8 0.012 14.2 19.8 1.0 1 0 0 1 1 1 0 Macoilin family HCO3_cotransp PF00955.21 CDI75171.1 - 0.011 14.6 6.0 0.014 14.2 6.0 1.3 1 0 0 1 1 1 0 HCO3- transporter family SelP_N PF04592.14 CDI75171.1 - 0.017 14.5 31.4 0.022 14.2 31.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RR_TM4-6 PF06459.12 CDI75171.1 - 0.023 14.5 15.8 0.025 14.4 15.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1387 PF07139.11 CDI75171.1 - 0.035 13.9 16.4 0.04 13.6 16.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DDRGK PF09756.9 CDI75171.1 - 0.036 13.7 18.4 0.044 13.4 18.4 1.1 1 0 0 1 1 1 0 DDRGK domain DDHD PF02862.17 CDI75171.1 - 0.039 14.1 13.4 0.045 13.9 13.4 1.1 1 0 0 1 1 1 0 DDHD domain Activator_LAG-3 PF11498.8 CDI75171.1 - 0.041 12.9 38.9 0.052 12.5 38.9 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 FAM76 PF16046.5 CDI75171.1 - 0.051 12.9 17.0 0.064 12.6 17.0 1.2 1 0 0 1 1 1 0 FAM76 protein SID-1_RNA_chan PF13965.6 CDI75171.1 - 0.064 11.7 4.7 0.067 11.6 4.7 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TFIIA PF03153.13 CDI75171.1 - 0.079 12.9 40.4 0.096 12.7 40.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4820 PF16091.5 CDI75171.1 - 0.081 12.3 11.6 0.11 11.8 11.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) BORG_CEP PF14957.6 CDI75171.1 - 0.085 14.0 7.9 0.099 13.8 7.9 1.2 1 0 0 1 1 1 0 Cdc42 effector IHABP4_N PF16174.5 CDI75171.1 - 0.092 13.4 23.2 0.11 13.0 23.2 1.0 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Suf PF05843.14 CDI75171.1 - 0.1 12.5 17.1 0.14 12.1 17.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Sec62 PF03839.16 CDI75171.1 - 0.11 11.9 11.5 0.13 11.7 11.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Ureide_permease PF07168.11 CDI75171.1 - 0.12 11.1 5.4 0.14 10.9 5.4 1.3 1 0 0 1 1 1 0 Ureide permease Tim54 PF11711.8 CDI75171.1 - 0.12 11.1 11.0 0.14 10.9 11.0 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RIFIN PF02009.16 CDI75171.1 - 0.12 12.2 12.8 0.15 11.9 12.8 1.1 1 0 0 1 1 1 0 Rifin Neur_chan_memb PF02932.16 CDI75171.1 - 0.13 12.3 14.1 0.15 12.1 14.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Gti1_Pac2 PF09729.9 CDI75171.1 - 0.14 12.3 13.4 0.16 12.1 13.4 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family CDC45 PF02724.14 CDI75171.1 - 0.14 10.4 11.1 0.15 10.4 11.1 1.1 1 0 0 1 1 1 0 CDC45-like protein AF-4 PF05110.13 CDI75171.1 - 0.15 10.1 23.8 0.16 10.0 23.8 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein MMR1 PF08505.10 CDI75171.1 - 0.16 12.3 22.6 0.18 12.0 22.6 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SOBP PF15279.6 CDI75171.1 - 0.2 12.2 18.4 0.23 12.0 18.4 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Roughex PF06020.11 CDI75171.1 - 0.24 10.5 8.1 0.31 10.1 8.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Med3 PF11593.8 CDI75171.1 - 0.25 10.5 35.7 0.35 10.0 35.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal CSG2 PF16965.5 CDI75171.1 - 0.26 10.2 6.2 0.29 10.1 6.2 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator CobT PF06213.12 CDI75171.1 - 0.29 10.5 21.5 0.35 10.2 21.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MID_MedPIWI PF18296.1 CDI75171.1 - 0.3 10.8 15.5 0.39 10.5 15.5 1.4 1 0 0 1 1 1 0 MID domain of medPIWI CAC1F_C PF16885.5 CDI75171.1 - 0.31 10.7 14.1 0.35 10.5 14.1 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Dicty_REP PF05086.12 CDI75171.1 - 0.34 8.8 18.8 0.4 8.6 18.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PBP_sp32 PF07222.12 CDI75171.1 - 0.35 10.3 17.5 0.42 10.0 17.5 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 FAM60A PF15396.6 CDI75171.1 - 0.36 10.8 13.6 0.42 10.6 13.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A RP-C_C PF11800.8 CDI75171.1 - 0.36 10.9 17.6 0.45 10.6 17.6 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region eIF-3_zeta PF05091.12 CDI75171.1 - 0.37 9.7 20.9 0.4 9.6 20.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DREPP PF05558.12 CDI75171.1 - 0.42 10.5 4.2 0.58 10.0 4.2 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Raftlin PF15250.6 CDI75171.1 - 0.48 9.1 15.1 0.52 9.0 15.1 1.0 1 0 0 1 1 1 0 Raftlin Med15 PF09606.10 CDI75171.1 - 0.49 9.0 30.9 0.57 8.8 30.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CKAP2_C PF15297.6 CDI75171.1 - 0.5 9.4 13.3 0.57 9.2 13.3 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus SLC12 PF03522.15 CDI75171.1 - 0.52 9.3 18.7 0.56 9.2 18.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 O-antigen_lig PF13425.6 CDI75171.1 - 0.55 9.0 6.0 0.6 8.8 6.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Presenilin PF01080.17 CDI75171.1 - 0.57 8.9 25.9 0.68 8.6 25.9 1.1 1 0 0 1 1 1 0 Presenilin Spore_coat_CotO PF14153.6 CDI75171.1 - 0.58 10.1 19.7 0.72 9.8 19.7 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Endostatin PF06482.11 CDI75171.1 - 0.6 9.5 19.9 0.68 9.3 19.9 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Serinc PF03348.15 CDI75171.1 - 0.6 9.0 10.1 0.74 8.7 10.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Velvet PF11754.8 CDI75171.1 - 0.62 10.0 17.2 0.74 9.7 17.2 1.2 1 0 0 1 1 1 0 Velvet factor Otopetrin PF03189.13 CDI75171.1 - 0.67 8.7 9.8 0.73 8.6 9.8 1.3 1 0 0 1 1 1 0 Otopetrin PAT1 PF09770.9 CDI75171.1 - 0.7 8.1 30.7 0.81 7.9 30.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NPR3 PF03666.13 CDI75171.1 - 0.7 8.6 17.2 0.8 8.4 17.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_S15 PF02129.18 CDI75171.1 - 0.77 9.3 15.3 0.93 9.0 15.3 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) SGIII PF15467.6 CDI75171.1 - 0.79 8.9 12.6 0.92 8.7 12.6 1.0 1 0 0 1 1 1 0 Secretogranin-3 Peptidase_S64 PF08192.11 CDI75171.1 - 0.83 8.1 14.8 0.94 7.9 14.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 NEMP PF10225.9 CDI75171.1 - 0.83 9.3 2.5 1 8.9 2.5 1.3 1 0 0 1 1 1 0 NEMP family ALMT PF11744.8 CDI75171.1 - 0.87 8.3 16.6 0.96 8.2 16.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CLN3 PF02487.17 CDI75171.1 - 1 8.3 12.0 1.2 8.2 12.0 1.2 1 0 0 1 1 1 0 CLN3 protein Spem1 PF15670.5 CDI75171.1 - 1.2 8.6 16.6 1.5 8.4 16.6 1.2 1 0 0 1 1 1 0 Spermatid maturation protein 1 CDK5_activator PF03261.15 CDI75171.1 - 1.3 8.5 16.3 1.4 8.4 16.3 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein XRN_M PF17846.1 CDI75171.1 - 1.4 7.8 11.7 1.6 7.6 11.7 1.2 1 0 0 1 1 1 0 Xrn1 helical domain MDM10 PF12519.8 CDI75171.1 - 1.5 7.6 15.0 1.8 7.4 15.0 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Exonuc_VII_L PF02601.15 CDI75171.1 - 1.5 8.3 24.4 1.8 8.1 24.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.16 CDI75171.1 - 1.5 7.6 9.6 1.6 7.5 9.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF936 PF06075.12 CDI75171.1 - 1.7 7.5 17.8 2 7.2 17.8 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) DUF3984 PF13136.6 CDI75171.1 - 1.7 8.0 20.9 2 7.8 20.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) Membralin PF09746.9 CDI75171.1 - 1.8 7.5 12.0 2 7.3 12.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein TCP PF03634.13 CDI75171.1 - 1.9 9.0 21.7 2.6 8.6 21.7 1.2 1 0 0 1 1 1 0 TCP family transcription factor DUF4045 PF13254.6 CDI75171.1 - 2 7.9 19.8 2.4 7.7 19.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF4746 PF15928.5 CDI75171.1 - 2.1 7.7 11.6 2.5 7.4 11.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) GREB1 PF15782.5 CDI75171.1 - 2.1 5.3 20.2 2.4 5.2 20.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Paramyxo_ncap PF00973.19 CDI75171.1 - 2.6 6.9 15.7 2.9 6.7 15.7 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein BAF1_ABF1 PF04684.13 CDI75171.1 - 3.4 6.6 26.2 4.4 6.2 26.2 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor RskA PF10099.9 CDI75171.1 - 3.9 7.7 17.8 8.7 6.6 17.8 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA MAJIN PF15077.6 CDI75171.1 - 3.9 7.2 15.7 4.6 7.0 15.7 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein HemX PF04375.14 CDI75171.1 - 4.1 6.6 31.4 5 6.3 31.4 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase SMYLE_N PF18615.1 CDI75171.1 - 5.1 6.6 15.1 6.3 6.2 15.1 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain DUF4638 PF15472.6 CDI75171.1 - 6 6.5 14.4 7.7 6.2 14.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Band_3_cyto PF07565.13 CDI75171.1 - 6.2 6.5 17.7 7.6 6.2 17.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Hid1 PF12722.7 CDI75171.1 - 8.5 4.4 19.4 9.4 4.2 19.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein YbgS PF13985.6 CDI75171.1 - 8.8 6.6 20.2 15 5.9 20.3 1.3 1 1 0 1 1 1 0 YbgS-like protein EMC3_TMCO1 PF01956.16 CDI75171.1 - 9.1 6.0 6.5 11 5.7 6.5 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like FliP PF00813.20 CDI75171.1 - 9.3 6.1 6.2 11 5.8 6.2 1.3 1 0 0 1 1 1 0 FliP family SR-25 PF10500.9 CDI75172.1 - 1.9 8.1 44.1 0.028 14.0 23.7 2.6 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein BatA PF07584.11 CDI75173.1 - 0.062 13.7 0.5 0.062 13.7 0.5 3.4 3 2 1 4 4 4 0 Aerotolerance regulator N-terminal DUF1289 PF06945.13 CDI75173.1 - 9.9 6.1 6.7 13 5.7 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) Auxin_canalis PF05703.11 CDI75174.1 - 0.18 11.7 33.4 0.23 11.4 33.4 1.2 1 0 0 1 1 1 0 Auxin canalisation MMR1 PF08505.10 CDI75174.1 - 8.9 6.5 40.5 9.9 6.4 40.5 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SR-25 PF10500.9 CDI75175.1 - 0.00036 20.2 11.5 0.00036 20.2 11.5 7.4 7 0 0 7 7 7 2 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI75175.1 - 0.0007 19.3 9.4 0.0007 19.3 9.4 7.8 5 2 1 6 6 6 2 Spt20 family UPF0564 PF10595.9 CDI75175.1 - 0.0027 16.8 3.7 0.0027 16.8 3.7 5.4 5 1 0 5 5 5 2 Uncharacterised protein family UPF0564 DUF2722 PF10846.8 CDI75175.1 - 0.0037 16.3 9.4 0.0037 16.3 9.4 7.8 5 2 2 7 7 7 2 Protein of unknown function (DUF2722) Trp_oprn_chp PF09534.10 CDI75175.1 - 0.01 15.7 4.2 0.01 15.7 4.2 7.2 4 2 2 6 6 6 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF1645 PF07816.11 CDI75175.1 - 0.012 16.2 4.7 0.012 16.2 4.7 6.1 3 2 2 5 5 5 0 Protein of unknown function (DUF1645) Dehydrin PF00257.19 CDI75175.1 - 0.021 15.4 1.4 0.021 15.4 1.4 10.6 7 3 0 7 7 7 0 Dehydrin SARAF PF06682.12 CDI75176.1 - 1.6 8.3 23.8 2 8.0 23.8 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2828 PF11443.8 CDI75176.1 - 4.1 5.4 16.1 4.6 5.2 16.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Gti1_Pac2 PF09729.9 CDI75176.1 - 4.2 7.4 12.8 5.7 7.0 12.8 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family PIP5K PF01504.18 CDI75176.1 - 4.6 6.4 13.6 5.8 6.0 13.6 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase FAM60A PF15396.6 CDI75176.1 - 5.5 6.9 15.0 7.6 6.5 15.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 CDI75176.1 - 6.3 5.4 21.8 7.7 5.2 21.8 1.0 1 0 0 1 1 1 0 Presenilin Folliculin PF11704.8 CDI75176.1 - 7.3 6.4 15.0 9.6 6.0 15.0 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Sin_N PF04801.13 CDI75176.1 - 8.3 5.5 31.1 12 5.0 31.1 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region DUF1180 PF06679.12 CDI75176.1 - 8.8 6.7 9.3 11 6.4 9.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) GETHR PF05671.11 CDI75178.1 - 5.5e-07 28.9 13.2 5.5e-07 28.9 13.2 7.5 3 2 1 4 4 4 1 GETHR pentapeptide repeat (5 copies) ERGIC_N PF13850.6 CDI75179.1 - 0.0056 17.0 1.6 0.032 14.6 0.6 2.6 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) NGP1NT PF08153.12 CDI75180.1 - 6.3e-35 120.2 0.0 1.5e-34 119.0 0.0 1.6 2 0 0 2 2 2 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 CDI75180.1 - 5.2e-16 58.7 0.0 6.7e-13 48.7 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDI75180.1 - 1.9e-07 31.1 0.0 4.8e-07 29.8 0.0 1.6 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 CDI75180.1 - 7.5e-06 25.6 0.0 0.0022 17.6 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B Arf PF00025.21 CDI75180.1 - 0.00017 21.1 0.1 0.29 10.6 0.1 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDI75180.1 - 0.00018 21.1 0.1 0.0021 17.6 0.1 2.3 1 1 1 3 3 3 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CDI75180.1 - 0.091 12.8 0.2 7.2 6.6 0.0 3.0 2 1 1 3 3 3 0 Dynamin family AAA_16 PF13191.6 CDI75180.1 - 0.15 12.4 0.3 6 7.2 0.0 2.6 1 1 1 2 2 2 0 AAA ATPase domain Beta-Casp PF10996.8 CDI75181.1 - 1.2e-17 64.2 0.0 3.1e-17 62.9 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 CDI75181.1 - 5.1e-16 58.4 0.0 1e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 CDI75181.1 - 2.3e-06 27.8 0.0 5.1e-05 23.4 0.0 3.1 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 CDI75181.1 - 2e-05 24.1 0.0 0.00014 21.4 0.0 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 CDI75181.1 - 0.0014 18.2 0.1 0.089 12.3 0.0 2.9 3 0 0 3 3 3 1 Beta-lactamase superfamily domain Cpn60_TCP1 PF00118.24 CDI75182.1 - 1.1e-79 268.4 0.3 4e-79 266.5 0.3 1.9 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family GP3_package PF16677.5 CDI75182.1 - 0.19 11.9 1.3 4.3 7.5 0.1 2.5 2 0 0 2 2 2 0 DNA-packaging protein gp3 DNA_primase_lrg PF04104.14 CDI75182.1 - 0.42 10.0 3.1 1.6 8.1 0.3 2.2 1 1 1 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit Myco_arth_vir_N PF09610.10 CDI75182.1 - 7.8 6.7 5.5 25 5.1 5.5 1.8 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Aminotran_1_2 PF00155.21 CDI75183.1 - 2.5e-38 132.2 0.0 3.8e-38 131.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II OKR_DC_1 PF01276.20 CDI75183.1 - 0.00024 20.0 0.0 0.00091 18.1 0.0 1.7 1 1 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Cys_Met_Meta_PP PF01053.20 CDI75183.1 - 0.00078 18.1 0.0 0.0014 17.2 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CDI75183.1 - 0.0012 18.3 0.5 0.037 13.3 0.6 2.7 2 1 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CDI75183.1 - 0.087 12.1 0.1 0.17 11.1 0.1 1.4 1 1 0 1 1 1 0 Beta-eliminating lyase ORC6 PF05460.13 CDI75184.1 - 1.6 7.9 8.4 2 7.6 8.4 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) eIF3_subunit PF08597.10 CDI75184.1 - 1.8 8.4 14.4 2.6 7.9 14.4 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Striatin PF08232.12 CDI75184.1 - 2.5 8.7 5.8 3.6 8.2 5.8 1.2 1 0 0 1 1 1 0 Striatin family Spt20 PF12090.8 CDI75185.1 - 0.011 15.4 10.8 0.011 15.4 10.8 2.1 2 0 0 2 2 2 0 Spt20 family SPX PF03105.19 CDI75185.1 - 1.6 8.6 24.2 3.8 7.3 1.1 2.0 2 0 0 2 2 2 0 SPX domain Rrn6 PF10214.9 CDI75186.1 - 0.005 15.4 10.3 0.0054 15.3 10.3 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor VIT1 PF01988.19 CDI75186.1 - 0.15 12.0 6.0 0.22 11.4 6.0 1.2 1 0 0 1 1 1 0 VIT family Spore_coat_CotO PF14153.6 CDI75186.1 - 0.18 11.7 11.4 0.27 11.1 11.4 1.3 1 0 0 1 1 1 0 Spore coat protein CotO DUF4964 PF16334.5 CDI75186.1 - 0.33 10.5 0.1 0.33 10.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4964) DOR PF14839.6 CDI75186.1 - 0.35 10.8 9.4 0.54 10.2 9.4 1.2 1 0 0 1 1 1 0 DOR family UPF0542 PF15086.6 CDI75186.1 - 0.96 9.4 5.1 2.3 8.2 1.7 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 Presenilin PF01080.17 CDI75186.1 - 1.4 7.6 7.9 1.7 7.4 7.9 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI75186.1 - 2.8 7.9 4.4 3.3 7.7 4.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ribosomal_60s PF00428.19 CDI75186.1 - 3.4 8.3 11.2 0.85 10.2 5.7 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein TFIIA PF03153.13 CDI75186.1 - 3.6 7.5 21.7 4.8 7.1 21.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI75187.1 - 0.0002 21.3 0.2 0.0002 21.3 0.2 14.1 6 4 2 8 8 8 3 Unstructured region C-term to UIM in Ataxin3 N6_N4_Mtase PF01555.18 CDI75187.1 - 0.84 9.3 0.0 0.84 9.3 0.0 4.1 3 1 0 3 3 3 0 DNA methylase Connexin PF00029.19 CDI75189.1 - 0.00015 21.6 4.2 0.00016 21.6 4.2 1.2 1 0 0 1 1 1 1 Connexin SID-1_RNA_chan PF13965.6 CDI75189.1 - 0.0016 17.0 4.8 0.0019 16.7 4.8 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 eIF-3_zeta PF05091.12 CDI75189.1 - 0.0028 16.7 19.5 0.0029 16.6 19.5 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Velvet PF11754.8 CDI75189.1 - 0.0037 17.3 15.7 0.0042 17.1 15.7 1.1 1 0 0 1 1 1 1 Velvet factor TFIIA PF03153.13 CDI75189.1 - 0.0038 17.3 50.4 0.0048 17.0 50.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit O-antigen_lig PF13425.6 CDI75189.1 - 0.0054 15.6 3.2 0.0058 15.5 3.2 1.0 1 0 0 1 1 1 1 O-antigen ligase like membrane protein Peptidase_S49_N PF08496.10 CDI75189.1 - 0.012 15.7 12.7 0.016 15.2 12.7 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal LMBR1 PF04791.16 CDI75189.1 - 0.013 14.5 7.4 0.014 14.3 7.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein PAT1 PF09770.9 CDI75189.1 - 0.013 13.8 29.6 0.013 13.8 29.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Serinc PF03348.15 CDI75189.1 - 0.014 14.3 9.0 0.016 14.1 9.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) AF-4 PF05110.13 CDI75189.1 - 0.016 13.3 21.0 0.018 13.1 21.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF1980 PF09323.10 CDI75189.1 - 0.017 15.0 12.2 0.024 14.5 12.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) CCSAP PF15748.5 CDI75189.1 - 0.023 14.9 16.9 0.026 14.7 16.9 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Tim54 PF11711.8 CDI75189.1 - 0.029 13.2 12.8 0.034 12.9 12.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DDHD PF02862.17 CDI75189.1 - 0.029 14.5 14.6 0.033 14.3 14.6 1.2 1 0 0 1 1 1 0 DDHD domain PIEZO PF15917.5 CDI75189.1 - 0.035 13.6 20.1 0.046 13.2 20.1 1.1 1 0 0 1 1 1 0 Piezo SpoIIP PF07454.11 CDI75189.1 - 0.035 13.6 18.0 0.043 13.3 18.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF913 PF06025.12 CDI75189.1 - 0.036 13.1 9.2 0.041 12.9 9.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 CDI75189.1 - 0.037 12.8 22.4 0.046 12.5 22.4 1.1 1 0 0 1 1 1 0 Presenilin SMYLE_N PF18615.1 CDI75189.1 - 0.044 13.3 14.1 0.054 13.0 14.1 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain AI-2E_transport PF01594.16 CDI75189.1 - 0.05 12.7 0.3 0.056 12.6 0.3 1.1 1 0 0 1 1 1 0 AI-2E family transporter Neur_chan_memb PF02932.16 CDI75189.1 - 0.057 13.5 10.8 0.061 13.4 10.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spc7_N PF15402.6 CDI75189.1 - 0.063 11.5 14.2 0.063 11.5 14.2 1.2 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 EOS1 PF12326.8 CDI75189.1 - 0.069 13.1 6.6 0.08 12.9 6.6 1.2 1 0 0 1 1 1 0 N-glycosylation protein Hamartin PF04388.12 CDI75189.1 - 0.073 11.7 15.9 0.08 11.6 15.9 1.0 1 0 0 1 1 1 0 Hamartin protein CSRNP_N PF16019.5 CDI75189.1 - 0.076 12.9 15.5 0.11 12.5 15.5 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF1764 PF08576.10 CDI75189.1 - 0.083 13.8 11.3 0.12 13.3 11.3 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF572 PF04502.13 CDI75189.1 - 0.089 12.4 16.1 0.099 12.3 16.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4471 PF14740.6 CDI75189.1 - 0.1 11.8 9.3 0.12 11.6 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) PA26 PF04636.13 CDI75189.1 - 0.1 11.5 12.2 0.12 11.3 12.2 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Exonuc_VII_L PF02601.15 CDI75189.1 - 0.11 12.1 21.9 0.14 11.7 21.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit MCM_bind PF09739.9 CDI75189.1 - 0.12 10.8 14.9 0.13 10.7 14.9 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CLN3 PF02487.17 CDI75189.1 - 0.14 11.2 15.3 0.15 11.0 14.6 1.2 1 1 0 1 1 1 0 CLN3 protein DUF719 PF05334.13 CDI75189.1 - 0.19 11.9 15.4 0.27 11.4 15.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF719) Ctr PF04145.15 CDI75189.1 - 0.22 12.1 9.1 0.31 11.6 9.1 1.4 1 0 0 1 1 1 0 Ctr copper transporter family MMU163 PF17119.5 CDI75189.1 - 0.23 10.6 5.6 0.29 10.3 5.6 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis RR_TM4-6 PF06459.12 CDI75189.1 - 0.28 11.0 19.6 0.36 10.6 19.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Endostatin PF06482.11 CDI75189.1 - 0.29 10.5 16.2 0.36 10.3 16.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin TERB2 PF15101.6 CDI75189.1 - 0.29 11.1 23.5 0.41 10.7 23.5 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CDC45 PF02724.14 CDI75189.1 - 0.35 9.1 13.9 0.4 8.9 13.9 1.1 1 0 0 1 1 1 0 CDC45-like protein HCO3_cotransp PF00955.21 CDI75189.1 - 0.37 9.6 5.7 0.4 9.5 5.7 1.1 1 0 0 1 1 1 0 HCO3- transporter family EPL1 PF10513.9 CDI75189.1 - 0.38 11.1 17.3 0.56 10.6 17.3 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like NEMP PF10225.9 CDI75189.1 - 0.41 10.3 10.1 0.54 9.9 10.1 1.1 1 0 0 1 1 1 0 NEMP family FAM60A PF15396.6 CDI75189.1 - 0.44 10.5 13.8 0.54 10.2 13.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A HemX PF04375.14 CDI75189.1 - 0.5 9.6 43.8 0.67 9.2 43.8 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4770 PF15994.5 CDI75189.1 - 0.6 10.3 19.7 0.95 9.7 19.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Activator_LAG-3 PF11498.8 CDI75189.1 - 0.64 8.9 54.7 0.96 8.3 54.7 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 YABBY PF04690.13 CDI75189.1 - 0.66 10.5 13.7 0.91 10.1 13.7 1.3 1 0 0 1 1 1 0 YABBY protein GREB1 PF15782.5 CDI75189.1 - 0.69 7.0 21.6 0.73 6.9 21.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer STAC2_u1 PF16664.5 CDI75189.1 - 0.7 10.4 13.6 1 9.8 13.6 1.3 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 SLC12 PF03522.15 CDI75189.1 - 0.73 8.8 18.7 0.84 8.6 18.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CSG2 PF16965.5 CDI75189.1 - 0.77 8.6 11.0 0.87 8.5 11.0 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator PPL5 PF18168.1 CDI75189.1 - 0.79 9.0 14.2 1 8.6 14.2 1.2 1 0 0 1 1 1 0 Prim-pol family 5 SprA-related PF12118.8 CDI75189.1 - 0.81 8.8 42.1 1.2 8.2 42.1 1.2 1 0 0 1 1 1 0 SprA-related family Macoilin PF09726.9 CDI75189.1 - 0.87 8.1 16.5 1.4 7.4 16.5 1.3 1 0 0 1 1 1 0 Macoilin family TFB6 PF17110.5 CDI75189.1 - 0.89 9.3 12.6 1.2 8.8 12.6 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH MCD PF05292.11 CDI75189.1 - 0.91 9.0 9.5 1.2 8.6 9.5 1.3 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain Gti1_Pac2 PF09729.9 CDI75189.1 - 0.94 9.5 15.0 1.2 9.2 15.0 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Dicty_REP PF05086.12 CDI75189.1 - 1 7.3 11.6 1.1 7.1 11.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FAM176 PF14851.6 CDI75189.1 - 1 9.0 12.1 1.5 8.5 12.1 1.3 1 0 0 1 1 1 0 FAM176 family Plasmodium_Vir PF05795.11 CDI75189.1 - 1.1 8.6 8.4 1.1 8.6 8.4 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF3408 PF11888.8 CDI75189.1 - 1.2 9.3 17.1 1.7 8.8 17.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF2828 PF11443.8 CDI75189.1 - 1.2 7.1 19.1 1.5 6.8 19.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) GNAT_acetyltr_2 PF13718.6 CDI75189.1 - 1.3 8.3 11.6 1.7 8.0 11.6 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Radical_SAM_N PF08497.10 CDI75189.1 - 1.4 8.1 9.3 1.6 7.9 9.3 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal DUF2126 PF09899.9 CDI75189.1 - 1.5 6.8 14.7 1.8 6.5 14.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Paf1 PF03985.13 CDI75189.1 - 1.6 7.7 21.8 1.9 7.4 21.8 1.1 1 0 0 1 1 1 0 Paf1 Endonuc_Holl PF10107.9 CDI75189.1 - 1.7 8.5 11.8 2.1 8.2 11.8 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase EMC3_TMCO1 PF01956.16 CDI75189.1 - 1.8 8.3 14.7 2.3 7.9 14.7 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF740 PF05340.12 CDI75189.1 - 1.9 7.2 11.1 2.3 6.9 11.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) Pkinase_fungal PF17667.1 CDI75189.1 - 1.9 7.2 11.1 2.2 7.0 11.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase Smg8_Smg9 PF10220.9 CDI75189.1 - 1.9 6.7 20.4 2.1 6.5 20.4 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Peptidase_S64 PF08192.11 CDI75189.1 - 2 6.8 19.2 2.4 6.5 19.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 BORG_CEP PF14957.6 CDI75189.1 - 2.1 9.5 14.3 2.7 9.2 14.3 1.2 1 0 0 1 1 1 0 Cdc42 effector CDC27 PF09507.10 CDI75189.1 - 2.1 7.6 22.1 2.7 7.3 22.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Het-C PF07217.11 CDI75189.1 - 2.5 6.5 13.5 2.9 6.3 13.5 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Cellulose_synt PF03552.14 CDI75189.1 - 2.7 6.4 7.7 3.1 6.2 7.7 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF1387 PF07139.11 CDI75189.1 - 2.8 7.6 19.9 3.3 7.4 19.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF3108 PF11306.8 CDI75189.1 - 2.8 7.9 10.6 3.3 7.6 10.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3108) NPR3 PF03666.13 CDI75189.1 - 2.8 6.6 18.1 3.4 6.4 18.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Band_3_cyto PF07565.13 CDI75189.1 - 2.9 7.6 20.6 3.7 7.3 20.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain EIF4E-T PF10477.9 CDI75189.1 - 2.9 6.6 26.9 3.5 6.3 26.9 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Paramyxo_ncap PF00973.19 CDI75189.1 - 2.9 6.7 15.5 3.6 6.4 15.5 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Baculo_PP31 PF05311.11 CDI75189.1 - 3.6 7.0 17.2 4.5 6.7 17.2 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Pal1 PF08316.11 CDI75189.1 - 3.6 8.3 11.5 5.6 7.7 11.5 1.3 1 0 0 1 1 1 0 Pal1 cell morphology protein MAJIN PF15077.6 CDI75189.1 - 3.7 7.3 15.5 4.5 7.0 15.5 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Lin-8 PF03353.15 CDI75189.1 - 3.8 7.0 24.3 4.6 6.7 24.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist ALMT PF11744.8 CDI75189.1 - 4 6.1 15.7 4.7 5.9 15.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FapA PF03961.13 CDI75189.1 - 4.3 5.8 11.6 5 5.6 11.6 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Rrn6 PF10214.9 CDI75189.1 - 4.6 5.6 27.8 5.1 5.5 27.8 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Pannexin_like PF12534.8 CDI75189.1 - 4.8 6.2 15.6 6.1 5.8 15.6 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 MMR1 PF08505.10 CDI75189.1 - 4.9 7.4 26.8 6.3 7.0 26.8 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF4746 PF15928.5 CDI75189.1 - 5 6.5 13.7 6.6 6.1 13.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MDM31_MDM32 PF08118.11 CDI75189.1 - 5.4 5.6 12.0 6.1 5.4 12.0 1.2 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins TCP PF03634.13 CDI75189.1 - 5.5 7.5 23.7 8.6 6.9 23.7 1.2 1 0 0 1 1 1 0 TCP family transcription factor Membralin PF09746.9 CDI75189.1 - 6.4 5.7 13.3 7.8 5.4 13.3 1.1 1 0 0 1 1 1 0 Tumour-associated protein Hid1 PF12722.7 CDI75189.1 - 6.7 4.7 20.5 7.6 4.5 20.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PRC2_HTH_1 PF18118.1 CDI75189.1 - 7.1 7.5 14.1 11 6.9 14.1 1.3 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain MPM1 PF17234.2 CDI75189.1 - 7.4 6.8 20.3 12 6.1 20.3 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 V_ATPase_I PF01496.19 CDI75189.1 - 8.3 4.2 21.4 10 3.9 21.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family 5_nucleotid PF05761.14 CDI75189.1 - 8.4 5.2 14.5 10 4.9 14.5 1.1 1 0 0 1 1 1 0 5' nucleotidase family Sec62 PF03839.16 CDI75189.1 - 8.8 5.8 16.0 11 5.4 16.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2722 PF10846.8 CDI75190.1 - 0.0018 17.3 13.7 0.0018 17.3 13.7 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) SAPS PF04499.15 CDI75190.1 - 0.018 13.8 7.7 0.54 9.0 0.3 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein HNOBA PF07701.14 CDI75190.1 - 0.77 9.1 13.7 0.066 12.6 0.1 2.2 2 0 0 2 2 2 0 Heme NO binding associated MecA PF05389.12 CDI75190.1 - 0.91 9.1 20.9 0.69 9.5 3.0 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) SpoIIP PF07454.11 CDI75190.1 - 1.2 8.6 25.6 2.1 7.8 8.8 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Neur_chan_memb PF02932.16 CDI75190.1 - 1.5 8.8 16.9 1.1 9.3 0.7 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.6 CDI75190.1 - 2.1 7.6 37.1 0.03 13.7 7.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) EOS1 PF12326.8 CDI75190.1 - 5.2 7.0 11.6 3.1 7.7 0.0 2.2 2 0 0 2 2 2 0 N-glycosylation protein MPM1 PF17234.2 CDI75190.1 - 5.7 7.2 24.0 2.8 8.2 5.1 2.5 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF913 PF06025.12 CDI75190.1 - 5.9 5.8 12.7 2 7.3 0.6 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) BAF1_ABF1 PF04684.13 CDI75191.1 - 2.3 7.2 19.8 3 6.8 19.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FAM104 PF15434.6 CDI75191.1 - 2.6 8.7 23.9 1.7 9.2 3.9 2.4 2 0 0 2 2 2 0 Family 104 Secretin_N_2 PF07655.13 CDI75191.1 - 3.6 8.2 39.9 3.9 8.1 10.4 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain TFIIA PF03153.13 CDI75192.1 - 8.9 6.2 33.9 11 5.9 33.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_17 PF13207.6 CDI75193.1 - 0.11 12.9 0.9 14 6.1 0.1 2.8 2 1 1 3 3 3 0 AAA domain PRKCSH_1 PF13015.6 CDI75193.1 - 0.11 12.2 0.0 6.9 6.3 0.0 2.3 2 0 0 2 2 2 0 Glucosidase II beta subunit-like protein SNF PF00209.18 CDI75194.1 - 0.00029 19.7 2.8 0.0004 19.2 0.0 2.1 2 1 0 2 2 2 1 Sodium:neurotransmitter symporter family IQ PF00612.27 CDI75195.1 - 3.7 7.6 8.5 39 4.4 0.0 2.5 2 0 0 2 2 2 0 IQ calmodulin-binding motif DUF4407 PF14362.6 CDI75196.1 - 0.0051 16.2 17.1 0.0051 16.2 17.1 6.1 2 1 2 5 5 5 1 Domain of unknown function (DUF4407) SF-assemblin PF06705.11 CDI75197.1 - 6.9e-28 97.6 13.0 2.1e-19 69.8 7.6 2.0 1 1 1 2 2 2 2 SF-assemblin/beta giardin ApoLp-III PF07464.11 CDI75197.1 - 0.0083 16.2 0.7 2.2 8.4 1.0 2.3 2 0 0 2 2 2 1 Apolipophorin-III precursor (apoLp-III) Mer2 PF09074.10 CDI75197.1 - 0.057 13.2 0.8 0.1 12.4 0.8 1.5 1 1 0 1 1 1 0 Mer2 HMMR_N PF15905.5 CDI75197.1 - 0.082 12.4 8.5 0.17 11.3 4.7 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF1664 PF07889.12 CDI75197.1 - 0.41 10.7 3.3 2.3 8.2 0.7 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Pex19 PF04614.12 CDI75197.1 - 0.46 10.2 2.9 0.59 9.9 2.4 1.4 1 1 0 1 1 1 0 Pex19 protein family Apolipoprotein PF01442.18 CDI75197.1 - 1.1 9.1 25.3 0.15 11.9 0.8 2.9 1 1 2 3 3 3 0 Apolipoprotein A1/A4/E domain PIN_8 PF18476.1 CDI75197.1 - 1.5 8.6 7.0 4.6 7.0 1.6 2.1 1 1 1 2 2 2 0 PIN like domain Osmo_CC PF08946.10 CDI75197.1 - 2.8 8.3 6.7 4.5 7.6 0.5 3.3 3 0 0 3 3 3 0 Osmosensory transporter coiled coil DUF507 PF04368.13 CDI75197.1 - 2.9 7.8 11.0 18 5.2 4.3 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF507) Exonuc_VII_L PF02601.15 CDI75197.1 - 3.3 7.2 11.8 15 5.0 11.8 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit zf-C2H2 PF00096.26 CDI75198.1 - 8.1e-06 26.0 0.3 1.5e-05 25.1 0.3 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 CDI75198.1 - 0.00081 20.1 1.9 0.0042 17.8 0.0 2.4 1 1 1 2 2 2 1 Zinc finger C2H2-type, 3 repeats XPA_N PF01286.18 CDI75198.1 - 0.0063 16.5 0.1 0.011 15.7 0.1 1.4 1 0 0 1 1 1 1 XPA protein N-terminal zf-C2H2_4 PF13894.6 CDI75198.1 - 0.02 15.7 0.3 0.043 14.7 0.3 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger Prefoldin_2 PF01920.20 CDI75198.1 - 0.023 14.7 8.3 0.023 14.7 8.3 2.8 2 1 1 3 3 3 0 Prefoldin subunit zf-C2H2_jaz PF12171.8 CDI75198.1 - 0.069 13.5 0.3 0.16 12.3 0.3 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding ARS2 PF04959.13 CDI75198.1 - 0.098 13.0 1.7 0.2 12.0 1.3 1.9 1 1 0 1 1 1 0 Arsenite-resistance protein 2 DUF3533 PF12051.8 CDI75198.1 - 0.51 9.2 5.6 0.73 8.7 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) DUF5320 PF17253.2 CDI75198.1 - 0.61 11.2 3.2 1.6 9.9 3.1 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5320) TFIIA PF03153.13 CDI75198.1 - 2.4 8.1 22.6 3.9 7.4 22.6 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MORN PF02493.20 CDI75200.1 - 4.2e-11 42.0 29.2 1.9e-05 24.3 0.7 6.6 6 1 0 6 6 6 5 MORN repeat Arabino_trans_N PF17689.1 CDI75203.1 - 0.07 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Arabinosyltransferase concanavalin like domain Ephrin_rec_like PF07699.13 CDI75204.1 - 0.0026 17.5 5.3 0.0026 17.5 5.3 28.7 16 8 14 30 30 30 22 Putative ephrin-receptor like tRNA-synt_2 PF00152.20 CDI75205.1 - 2.5e-78 263.3 0.0 3.6e-78 262.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDI75205.1 - 1.5e-10 40.9 0.0 3.1e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDI75205.1 - 1e-07 31.7 0.0 6e-05 22.6 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) GCR1_C PF12550.8 CDI75205.1 - 0.16 12.3 0.5 0.96 9.8 0.0 2.4 3 0 0 3 3 3 0 Transcriptional activator of glycolytic enzymes NARP1 PF12569.8 CDI75205.1 - 0.41 9.5 7.0 0.62 8.9 7.0 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 rve PF00665.26 CDI75206.1 - 0.00055 20.1 0.0 0.00066 19.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Kelch_4 PF13418.6 CDI75211.1 - 5.2e-17 61.6 4.2 7e-08 32.4 0.1 3.6 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI75211.1 - 6.7e-10 38.7 1.7 0.0028 17.6 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 CDI75211.1 - 3.8e-07 30.2 9.4 0.0044 17.3 0.1 3.4 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 CDI75211.1 - 8.4e-06 25.9 4.3 0.11 12.8 0.1 3.5 2 1 1 3 3 3 2 Kelch motif Kelch_1 PF01344.25 CDI75211.1 - 4e-05 23.1 5.2 0.57 9.8 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 CDI75211.1 - 0.0048 16.8 2.5 1.7 8.7 0.1 3.4 3 0 0 3 3 3 1 Kelch motif PUNUT PF16913.5 CDI75211.1 - 0.026 13.8 0.8 0.035 13.3 0.8 1.1 1 0 0 1 1 1 0 Purine nucleobase transmembrane transport PSI_PsaJ PF01701.18 CDI75211.1 - 0.081 13.5 0.7 0.22 12.1 0.7 1.6 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IX / PsaJ EGF_2 PF07974.13 CDI75211.1 - 0.81 10.1 11.0 1.6 9.2 11.0 1.5 1 0 0 1 1 1 0 EGF-like domain CCDC106 PF15794.5 CDI75213.1 - 0.017 14.8 14.9 0.022 14.5 14.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SKA1 PF07160.12 CDI75213.1 - 0.022 14.6 4.6 0.026 14.4 4.6 1.0 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF737 PF05300.11 CDI75213.1 - 0.069 13.5 7.6 0.077 13.3 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF737) PI3K_1B_p101 PF10486.9 CDI75213.1 - 0.17 9.6 19.7 0.2 9.4 19.7 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RSRP PF17069.5 CDI75213.1 - 0.21 11.1 28.4 0.26 10.8 28.4 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 GEMIN8 PF15348.6 CDI75213.1 - 0.21 11.8 8.7 0.24 11.7 8.7 1.0 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 Kinesin_assoc PF16183.5 CDI75213.1 - 0.24 11.5 7.3 0.3 11.2 7.3 1.1 1 0 0 1 1 1 0 Kinesin-associated RAP1 PF07218.11 CDI75213.1 - 0.32 9.2 21.3 0.34 9.1 21.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SPX PF03105.19 CDI75213.1 - 0.36 10.7 16.0 0.41 10.5 16.0 1.1 1 0 0 1 1 1 0 SPX domain ASD2 PF08687.11 CDI75213.1 - 0.41 10.2 7.0 0.46 10.0 7.0 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Macoilin PF09726.9 CDI75213.1 - 0.45 9.0 22.2 0.5 8.9 22.2 1.1 1 0 0 1 1 1 0 Macoilin family TCP PF03634.13 CDI75213.1 - 0.47 11.0 16.7 0.63 10.6 16.7 1.1 1 0 0 1 1 1 0 TCP family transcription factor SR-25 PF10500.9 CDI75213.1 - 0.49 10.0 43.5 0.24 11.0 17.1 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein NPR3 PF03666.13 CDI75213.1 - 0.71 8.6 12.3 0.77 8.5 12.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF515 PF04415.12 CDI75213.1 - 0.73 8.2 23.9 0.84 8.0 23.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Sec3_C PF09763.9 CDI75213.1 - 0.81 8.0 11.2 0.93 7.8 11.2 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec3 DUF4698 PF15769.5 CDI75213.1 - 0.86 8.6 16.5 1 8.4 16.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Apt1 PF10351.9 CDI75213.1 - 0.88 8.4 19.5 0.94 8.3 19.5 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Pannexin_like PF12534.8 CDI75213.1 - 0.88 8.6 6.4 0.95 8.5 6.4 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 HGTP_anticodon2 PF12745.7 CDI75213.1 - 0.9 9.0 11.5 1.1 8.7 11.5 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Tmemb_cc2 PF10267.9 CDI75213.1 - 1 8.4 12.4 1.2 8.2 12.4 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein FAM76 PF16046.5 CDI75213.1 - 1.1 8.5 10.9 1.3 8.3 10.9 1.1 1 0 0 1 1 1 0 FAM76 protein Lin-8 PF03353.15 CDI75213.1 - 1.4 8.4 9.3 1.9 8.0 9.3 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RIC3 PF15361.6 CDI75213.1 - 1.4 9.3 5.3 3.1 8.2 5.1 1.6 1 1 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Presenilin PF01080.17 CDI75213.1 - 1.7 7.3 11.9 1.9 7.2 11.9 1.0 1 0 0 1 1 1 0 Presenilin FAM199X PF15814.5 CDI75213.1 - 1.7 7.6 22.3 1.8 7.6 22.3 1.1 1 0 0 1 1 1 0 Protein family FAM199X ANAPC1 PF12859.7 CDI75213.1 - 1.8 9.1 9.6 2 9.0 9.6 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 AF-4 PF05110.13 CDI75213.1 - 2 6.4 31.5 2.5 6.1 31.5 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SSP160 PF06933.11 CDI75213.1 - 2.3 6.3 29.9 2.7 6.1 29.9 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Smg8_Smg9 PF10220.9 CDI75213.1 - 2.5 6.3 12.4 2.8 6.2 12.4 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Zip PF02535.22 CDI75213.1 - 3.3 6.8 6.8 3.7 6.7 6.8 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Raftlin PF15250.6 CDI75213.1 - 3.3 6.4 9.2 3.7 6.2 9.2 1.0 1 0 0 1 1 1 0 Raftlin Menin PF05053.13 CDI75213.1 - 3.4 5.9 12.3 3.6 5.8 12.3 1.0 1 0 0 1 1 1 0 Menin Period_C PF12114.8 CDI75213.1 - 3.7 7.1 24.1 4.2 6.9 24.1 1.1 1 0 0 1 1 1 0 Period protein 2/3C-terminal region PAP1 PF08601.10 CDI75213.1 - 4.4 6.9 20.5 4.8 6.8 20.5 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Peptidase_S64 PF08192.11 CDI75213.1 - 4.6 5.6 17.6 5.5 5.3 17.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 CytochromB561_N PF09786.9 CDI75213.1 - 5 6.0 16.8 5.6 5.8 16.8 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal Miga PF10265.9 CDI75213.1 - 6.4 5.6 16.1 7.1 5.5 16.1 1.1 1 0 0 1 1 1 0 Mitoguardin CAML PF14963.6 CDI75213.1 - 6.5 6.8 11.6 7.6 6.6 11.6 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand SID-1_RNA_chan PF13965.6 CDI75213.1 - 7.2 4.9 6.9 7.6 4.8 6.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF5423 PF17461.2 CDI75213.1 - 9.5 5.0 19.1 9.8 4.9 19.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5423) YajC PF02699.15 CDI75214.1 - 0.035 14.0 0.6 0.044 13.7 0.6 1.1 1 0 0 1 1 1 0 Preprotein translocase subunit SUIM_assoc PF16619.5 CDI75214.1 - 0.088 12.9 8.3 0.17 12.0 5.2 2.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Pentapeptide PF00805.22 CDI75215.1 - 2.9e-09 36.4 0.0 1.6 8.4 0.0 6.3 1 1 1 5 5 5 4 Pentapeptide repeats (8 copies) CfAFP PF05264.11 CDI75215.1 - 0.013 15.4 0.6 3.4 7.6 0.1 2.6 1 1 1 2 2 2 0 Choristoneura fumiferana antifreeze protein (CfAFP) SDA1 PF05285.12 CDI75216.1 - 0.25 10.7 32.9 0.28 10.6 32.9 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 CDI75216.1 - 0.28 9.4 34.5 0.27 9.4 34.5 1.0 1 0 0 1 1 1 0 Nop14-like family Mpp10 PF04006.12 CDI75216.1 - 0.52 8.7 32.7 0.61 8.5 32.7 1.1 1 0 0 1 1 1 0 Mpp10 protein DUF913 PF06025.12 CDI75216.1 - 0.53 9.2 8.4 0.59 9.1 8.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4337 PF14235.6 CDI75216.1 - 0.57 10.3 3.0 0.63 10.1 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Tim54 PF11711.8 CDI75216.1 - 0.77 8.5 12.7 0.83 8.4 12.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 CDI75216.1 - 0.77 9.5 19.8 0.92 9.3 19.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BUD22 PF09073.10 CDI75216.1 - 1 8.6 29.5 1.1 8.5 29.5 1.0 1 0 0 1 1 1 0 BUD22 CCSAP PF15748.5 CDI75216.1 - 1.3 9.2 13.0 1.4 9.1 13.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SpoIIIAH PF12685.7 CDI75216.1 - 2 8.2 16.5 2.2 8.1 16.5 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Presenilin PF01080.17 CDI75216.1 - 2 7.1 13.8 2.1 7.0 13.8 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 CDI75216.1 - 2.8 7.1 10.6 3.6 6.7 10.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 CDI75216.1 - 4.4 6.0 11.4 4.4 6.0 11.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PTPRCAP PF15713.5 CDI75216.1 - 4.6 7.5 36.0 6.3 7.1 36.0 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated FGF-BP1 PF06473.12 CDI75216.1 - 5.3 6.8 9.6 6.1 6.6 9.6 1.1 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) MDM1 PF15501.6 CDI75216.1 - 6.7 5.7 19.9 7 5.7 19.9 1.0 1 0 0 1 1 1 0 Nuclear protein MDM1 Vfa1 PF08432.10 CDI75216.1 - 8.4 6.7 15.4 11 6.3 15.4 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Glypican PF01153.19 CDI75216.1 - 9.4 4.9 8.1 11 4.7 8.1 1.0 1 0 0 1 1 1 0 Glypican F_actin_cap_B PF01115.17 CDI75217.1 - 9.7e-29 100.7 0.0 1.6e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 F-actin capping protein, beta subunit BCOR PF15808.5 CDI75217.1 - 0.0065 16.7 5.4 0.01 16.0 5.4 1.3 1 0 0 1 1 1 1 BCL-6 co-repressor, non-ankyrin-repeat region RskA PF10099.9 CDI75217.1 - 1.3 9.3 36.1 0.31 11.3 11.1 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI75217.1 - 5.9 6.8 17.8 8.4 6.3 17.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PRCC PF10253.9 CDI75217.1 - 7.1 7.4 16.0 2.1 9.1 9.0 2.1 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting FTZ PF03867.14 CDI75218.1 - 0.0069 16.0 6.6 0.0069 16.0 6.6 2.3 2 0 0 2 2 2 1 Fushi tarazu (FTZ), N-terminal region Spt20 PF12090.8 CDI75218.1 - 0.39 10.3 29.5 1.1 8.8 14.5 2.1 2 0 0 2 2 2 0 Spt20 family DUF4820 PF16091.5 CDI75218.1 - 0.56 9.5 6.2 0.96 8.8 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) AUX_IAA PF02309.16 CDI75218.1 - 3.1 7.6 15.7 77 3.0 15.7 2.1 1 1 0 1 1 1 0 AUX/IAA family BORG_CEP PF14957.6 CDI75218.1 - 3.7 8.7 6.6 13 7.0 1.0 2.2 2 0 0 2 2 2 0 Cdc42 effector EPL1 PF10513.9 CDI75218.1 - 4.8 7.5 14.6 2.1 8.7 0.5 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF4834 PF16118.5 CDI75218.1 - 5.5 8.0 15.6 3.1 8.8 5.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Med15 PF09606.10 CDI75219.1 - 0.0026 16.5 18.9 0.0026 16.5 18.9 4.5 3 1 1 4 4 4 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2722 PF10846.8 CDI75219.1 - 0.0061 15.6 20.1 0.0061 15.6 20.1 7.2 3 1 1 5 5 5 1 Protein of unknown function (DUF2722) LAP1C PF05609.12 CDI75222.1 - 0.00019 20.7 5.8 0.00021 20.5 5.8 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) Raftlin PF15250.6 CDI75222.1 - 0.001 17.9 5.7 0.0011 17.8 5.7 1.0 1 0 0 1 1 1 1 Raftlin Macoilin PF09726.9 CDI75222.1 - 0.0035 16.0 21.6 0.0047 15.6 21.6 1.2 1 0 0 1 1 1 1 Macoilin family Presenilin PF01080.17 CDI75222.1 - 0.2 10.4 10.4 0.31 9.8 10.4 1.3 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 CDI75222.1 - 0.22 10.7 3.7 0.26 10.5 3.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Miga PF10265.9 CDI75222.1 - 0.36 9.8 14.7 0.45 9.4 14.7 1.1 1 0 0 1 1 1 0 Mitoguardin SPX PF03105.19 CDI75222.1 - 0.49 10.2 20.3 0.61 9.9 20.3 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI75222.1 - 0.73 8.6 22.7 0.89 8.3 22.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_S64 PF08192.11 CDI75222.1 - 0.85 8.0 21.2 0.98 7.8 21.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 Tmemb_cc2 PF10267.9 CDI75222.1 - 0.96 8.5 11.6 1.3 8.1 11.6 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein SLC12 PF03522.15 CDI75222.1 - 1.2 8.0 8.8 1.4 7.8 8.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PNISR PF15996.5 CDI75222.1 - 2 8.7 12.7 2.6 8.3 12.7 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Utp14 PF04615.13 CDI75222.1 - 2.4 6.6 11.5 2.8 6.4 11.5 1.0 1 0 0 1 1 1 0 Utp14 protein GREB1 PF15782.5 CDI75222.1 - 2.7 5.0 14.3 2.8 5.0 14.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PPP4R2 PF09184.11 CDI75222.1 - 3.3 7.2 17.9 4.4 6.8 17.9 1.2 1 0 0 1 1 1 0 PPP4R2 DUF4769 PF15992.5 CDI75222.1 - 5.6 6.7 10.2 7.4 6.3 10.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) RNA12 PF10443.9 CDI75222.1 - 8.4 5.0 11.0 95 1.5 11.0 2.0 1 1 0 1 1 1 0 RNA12 protein Hamartin PF04388.12 CDI75222.1 - 9.9 4.7 19.9 13 4.3 19.9 1.0 1 0 0 1 1 1 0 Hamartin protein Hydrolase_3 PF08282.12 CDI75224.1 - 7.4e-37 127.5 0.0 4.8e-22 78.9 0.0 2.0 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDI75224.1 - 5.8e-07 29.3 0.0 0.00022 20.9 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CDI75224.1 - 1.2e-05 25.7 2.2 0.27 11.5 0.7 3.1 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Rsa3 PF14615.6 CDI75225.1 - 0.18 11.4 0.1 0.41 10.3 0.1 1.5 1 0 0 1 1 1 0 Ribosome-assembly protein 3 DUF572 PF04502.13 CDI75226.1 - 1.1 8.8 24.6 1.6 8.3 24.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) ASFV_J13L PF05568.11 CDI75227.1 - 8.4 6.1 8.2 4.1 7.1 4.6 2.1 2 0 0 2 2 2 0 African swine fever virus J13L protein TFIIA PF03153.13 CDI75228.1 - 0.0085 16.1 25.8 0.01 15.9 25.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 CDI75228.1 - 0.096 12.5 1.3 0.12 12.2 1.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Med15 PF09606.10 CDI75228.1 - 0.32 9.6 34.1 0.39 9.3 34.1 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SpoVR PF04293.13 CDI75228.1 - 0.45 9.2 5.4 0.58 8.8 5.4 1.1 1 0 0 1 1 1 0 SpoVR like protein DUF3295 PF11702.8 CDI75228.1 - 1.1 8.6 10.4 1.4 8.2 10.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) TERB2 PF15101.6 CDI75228.1 - 5 7.1 8.6 7.3 6.6 8.6 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 PAT1 PF09770.9 CDI75228.1 - 5.6 5.1 21.6 6.4 4.9 21.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AP2 PF00847.20 CDI75229.1 - 2.1e-10 40.6 0.3 9.3e-10 38.6 0.3 2.2 1 0 0 1 1 1 1 AP2 domain Trypan_PARP PF05887.11 CDI75230.1 - 7.9 6.5 25.6 0.6 10.1 18.5 2.4 1 1 2 3 3 3 0 Procyclic acidic repetitive protein (PARP) Hist_deacetyl PF00850.19 CDI75231.1 - 1.5 8.3 6.0 0.99 8.8 2.1 2.2 2 0 0 2 2 2 0 Histone deacetylase domain Moulting_cycle PF04870.16 CDI75232.1 - 0.028 13.7 9.2 0.034 13.4 9.2 1.1 1 0 0 1 1 1 0 Moulting cycle TFIIA PF03153.13 CDI75232.1 - 0.03 14.3 40.3 0.035 14.1 40.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2115 PF09888.9 CDI75232.1 - 0.59 10.6 7.2 0.78 10.2 7.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) Neur_chan_memb PF02932.16 CDI75232.1 - 1.1 9.3 7.9 1.1 9.2 7.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 CDI75232.1 - 1.2 8.1 11.8 1.3 8.0 11.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 OATP PF03137.20 CDI75232.1 - 1.2 7.3 3.9 1.3 7.2 3.9 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Band_3_cyto PF07565.13 CDI75232.1 - 1.3 8.7 9.7 1.7 8.4 9.7 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Serinc PF03348.15 CDI75232.1 - 2 7.3 5.2 2.2 7.1 5.2 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) PAT1 PF09770.9 CDI75232.1 - 2.3 6.4 28.1 2.3 6.4 28.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 V_ATPase_I PF01496.19 CDI75232.1 - 2.4 6.0 11.6 2.6 5.9 11.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GET2 PF08690.10 CDI75232.1 - 3.3 7.3 19.8 4 7.0 19.8 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 GIDA_assoc PF13932.6 CDI75232.1 - 3.6 7.7 14.1 6 7.0 14.1 1.4 1 0 0 1 1 1 0 GidA associated domain FUSC PF04632.12 CDI75232.1 - 9.2 4.7 24.0 12 4.2 24.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF445 PF04286.12 CDI75233.1 - 0.0068 16.3 9.2 0.0071 16.2 9.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF445) Activator_LAG-3 PF11498.8 CDI75233.1 - 0.016 14.2 30.5 0.017 14.1 30.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SprA-related PF12118.8 CDI75233.1 - 0.13 11.4 28.6 0.15 11.1 28.6 1.1 1 0 0 1 1 1 0 SprA-related family ZIP4_domain PF18292.1 CDI75233.1 - 0.3 11.0 15.7 0.43 10.5 15.7 1.4 1 1 0 1 1 1 0 Zinc transporter ZIP4 domain FliL PF03748.14 CDI75233.1 - 1.4 9.6 13.5 44 4.7 13.5 2.2 1 1 0 1 1 1 0 Flagellar basal body-associated protein FliL GET2 PF08690.10 CDI75233.1 - 7.2 6.2 17.8 12 5.4 17.8 1.4 1 1 0 1 1 1 0 GET complex subunit GET2 SMYLE_N PF18615.1 CDI75233.1 - 7.6 6.0 11.6 8.4 5.8 11.6 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain UCH PF00443.29 CDI75233.1 - 7.9 5.9 7.8 8.6 5.8 7.8 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase RNase_J_C PF17770.1 CDI75234.1 - 0.012 16.6 1.1 0.025 15.6 1.1 1.5 1 0 0 1 1 1 0 Ribonuclease J C-terminal domain Peptidase_C50 PF03568.17 CDI75234.1 - 0.086 11.9 9.2 0.094 11.8 9.2 1.0 1 0 0 1 1 1 0 Peptidase family C50 SurA_N_2 PF13623.6 CDI75234.1 - 0.26 11.2 21.2 0.37 10.7 21.2 1.4 1 0 0 1 1 1 0 SurA N-terminal domain Ofd1_CTDD PF10637.9 CDI75234.1 - 0.29 10.5 5.3 0.31 10.4 5.3 1.2 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term CsoSCA PF08936.10 CDI75234.1 - 0.41 9.3 8.8 0.45 9.1 8.8 1.1 1 0 0 1 1 1 0 Carboxysome Shell Carbonic Anhydrase Tam41_Mmp37 PF09139.11 CDI75234.1 - 0.94 8.9 10.2 0.99 8.8 10.2 1.1 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial ABC_trans_aux PF03886.13 CDI75234.1 - 1.2 8.7 26.3 0.28 10.8 15.3 2.0 1 1 1 2 2 2 0 ABC-type transport auxiliary lipoprotein component DUF5069 PF16798.5 CDI75234.1 - 1.3 9.2 5.6 1.2 9.4 4.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5069) DUF3589 PF12141.8 CDI75234.1 - 2.5 6.6 8.1 2.9 6.4 8.1 1.1 1 0 0 1 1 1 0 Beta-mannosyltransferases DUF2294 PF10057.9 CDI75234.1 - 3.2 7.9 12.5 14 5.8 12.4 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2294) HI0933_like PF03486.14 CDI75234.1 - 3.9 6.1 13.9 3 6.4 13.2 1.3 1 1 0 1 1 1 0 HI0933-like protein UPF0560 PF10577.9 CDI75234.1 - 3.9 5.8 16.0 3.8 5.9 16.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Adeno_PV PF03910.13 CDI75234.1 - 4.5 5.9 8.3 4.3 6.0 8.3 1.2 1 0 0 1 1 1 0 Adenovirus minor core protein PV 2OG-FeII_Oxy_2 PF13532.6 CDI75234.1 - 4.7 7.3 7.6 5 7.3 7.6 1.1 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily MID_MedPIWI PF18296.1 CDI75234.1 - 6.1 6.6 12.0 6.7 6.4 12.0 1.1 1 0 0 1 1 1 0 MID domain of medPIWI Vps39_2 PF10367.9 CDI75234.1 - 6.7 7.2 12.2 9.1 6.8 11.9 1.4 1 1 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 RIFIN PF02009.16 CDI75234.1 - 7.2 6.4 14.4 8.4 6.2 14.4 1.1 1 0 0 1 1 1 0 Rifin CD20 PF04103.15 CDI75235.1 - 0.021 14.9 0.0 0.021 14.9 0.0 2.7 1 1 2 3 3 3 0 CD20-like family TauE PF01925.19 CDI75235.1 - 0.23 11.1 1.1 0.3 10.7 1.1 1.1 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE VIR_N PF15912.5 CDI75235.1 - 3.1 7.3 16.6 3.9 7.0 16.6 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal PAT1 PF09770.9 CDI75235.1 - 8.3 4.5 57.2 9.3 4.4 57.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ribosomal_60s PF00428.19 CDI75236.1 - 3.4 8.3 13.4 13 6.4 13.4 2.0 1 0 0 1 1 1 0 60s Acidic ribosomal protein SSP160 PF06933.11 CDI75237.1 - 0.001 17.4 28.1 0.0011 17.2 28.1 1.0 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 Mlh1_C PF16413.5 CDI75237.1 - 0.064 12.6 0.0 0.077 12.4 0.0 1.0 1 0 0 1 1 1 0 DNA mismatch repair protein Mlh1 C-terminus Apt1 PF10351.9 CDI75237.1 - 0.23 10.3 18.2 0.27 10.0 18.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Rrn6 PF10214.9 CDI75237.1 - 0.58 8.6 16.1 0.62 8.5 16.1 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor GREB1 PF15782.5 CDI75237.1 - 0.62 7.1 7.5 0.7 6.9 7.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LRRFIP PF09738.9 CDI75237.1 - 1.4 8.3 11.2 1.6 8.1 11.2 1.1 1 0 0 1 1 1 0 LRRFIP family SPX PF03105.19 CDI75237.1 - 2.1 8.2 17.8 2.4 8.0 17.8 1.0 1 0 0 1 1 1 0 SPX domain ANAPC1 PF12859.7 CDI75237.1 - 3.8 8.1 14.9 5.4 7.6 14.9 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 Kei1 PF08552.11 CDI75237.1 - 4.2 7.2 7.2 5.6 6.8 7.2 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Hamartin PF04388.12 CDI75237.1 - 5.5 5.5 11.2 6 5.4 11.2 1.1 1 0 0 1 1 1 0 Hamartin protein HSD3 PF15244.6 CDI75237.1 - 7 6.1 19.1 9 5.7 19.1 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 Sec3_C PF09763.9 CDI75237.1 - 7.6 4.8 10.5 8.9 4.6 10.5 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec3 RskA PF10099.9 CDI75238.1 - 0.00034 21.0 20.7 0.00034 21.0 20.7 15.3 4 4 7 11 11 11 3 Anti-sigma-K factor rskA CRF1 PF10380.9 CDI75238.1 - 0.98 9.8 0.0 0.98 9.8 0.0 8.4 7 4 2 9 9 9 0 Transcription factor CRF1 Inj_translocase PF16928.5 CDI75239.1 - 0.00058 19.4 8.2 0.00081 18.9 8.2 1.2 1 0 0 1 1 1 1 DNA/protein translocase of phage P22 injectosome Ribosomal_60s PF00428.19 CDI75239.1 - 0.37 11.4 15.1 0.39 11.3 4.5 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein TFIIA PF03153.13 CDI75239.1 - 0.65 9.9 10.4 0.77 9.7 10.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BAF1_ABF1 PF04684.13 CDI75239.1 - 3.7 6.5 8.4 4.9 6.1 8.4 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Hist_deacetyl PF00850.19 CDI75239.1 - 6 6.2 7.3 24 4.3 7.3 1.8 1 1 0 1 1 1 0 Histone deacetylase domain Prenyltrans PF00432.21 CDI75239.1 - 8.2 6.3 7.2 0.23 11.3 0.7 1.8 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat NST1 PF13945.6 CDI75241.1 - 0.04 14.0 1.4 0.047 13.8 1.4 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator RNA_polI_A34 PF08208.11 CDI75241.1 - 0.081 13.0 8.1 0.091 12.8 8.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 XRCC4 PF06632.12 CDI75241.1 - 0.26 10.1 6.0 0.31 9.9 6.0 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 eIF3_subunit PF08597.10 CDI75241.1 - 0.33 10.8 14.9 0.43 10.4 14.9 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF3807 PF12720.7 CDI75241.1 - 0.59 10.4 5.2 0.66 10.2 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF4604 PF15377.6 CDI75241.1 - 1.4 9.3 14.6 1.9 8.9 14.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) DUF1682 PF07946.14 CDI75241.1 - 2.9 7.0 8.8 4.1 6.5 8.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) SWI-SNF_Ssr4 PF08549.10 CDI75241.1 - 4.9 5.7 9.7 5.5 5.5 9.7 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) BAF1_ABF1 PF04684.13 CDI75241.1 - 6.6 5.7 12.1 9.2 5.2 12.1 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4366 PF14283.6 CDI75241.1 - 8 6.5 10.5 12 5.9 10.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) RskA PF10099.9 CDI75242.1 - 0.00028 21.2 4.6 0.00028 21.2 4.6 15.7 5 4 2 8 8 8 2 Anti-sigma-K factor rskA Chordopox_G3 PF06129.12 CDI75242.1 - 0.089 13.5 2.0 0.52 11.0 0.1 3.4 2 0 0 2 2 2 0 Chordopoxvirus G3 protein Ribosomal_60s PF00428.19 CDI75243.1 - 0.011 16.3 19.2 0.011 16.3 19.2 5.5 4 1 0 4 4 4 0 60s Acidic ribosomal protein OATP PF03137.20 CDI75245.1 - 0.0039 15.5 0.7 0.0039 15.5 0.7 3.6 3 2 0 3 3 1 1 Organic Anion Transporter Polypeptide (OATP) family ApbA PF02558.16 CDI75245.1 - 0.0046 16.6 0.2 0.016 14.9 0.2 1.9 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA PPP4R2 PF09184.11 CDI75245.1 - 0.0064 16.1 3.6 0.0064 16.1 3.6 3.2 2 1 1 3 3 1 1 PPP4R2 RskA PF10099.9 CDI75245.1 - 0.0076 16.6 42.2 0.16 12.3 28.1 4.1 3 1 0 3 3 3 2 Anti-sigma-K factor rskA ThiF PF00899.21 CDI75245.1 - 0.025 13.9 1.8 0.025 13.9 1.8 2.4 2 1 1 3 3 3 0 ThiF family Thionin PF00321.17 CDI75245.1 - 0.038 14.5 1.3 0.038 14.5 1.3 2.4 2 0 0 2 2 2 0 Plant thionin UBA_e1_thiolCys PF10585.9 CDI75245.1 - 0.087 12.7 0.0 0.087 12.7 0.0 4.5 3 1 1 4 4 3 0 Ubiquitin-activating enzyme active site adh_short PF00106.25 CDI75245.1 - 0.12 11.8 5.6 0.21 11.0 4.0 2.2 2 0 0 2 2 2 0 short chain dehydrogenase DUF2126 PF09899.9 CDI75245.1 - 0.13 10.3 20.1 0.015 13.4 7.8 2.3 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) SDA1 PF05285.12 CDI75245.1 - 0.58 9.5 49.1 0.35 10.2 24.5 2.3 2 0 0 2 2 2 0 SDA1 TPP_enzyme_C PF02775.21 CDI75245.1 - 0.63 9.8 13.9 0.062 13.1 3.9 3.4 2 2 1 3 3 3 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TFIIA PF03153.13 CDI75246.1 - 0.14 12.1 18.7 0.2 11.6 18.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SpoIIIAH PF12685.7 CDI75248.1 - 0.00054 19.8 5.6 0.00054 19.8 5.6 2.9 2 1 0 2 2 2 1 SpoIIIAH-like protein PAT1 PF09770.9 CDI75248.1 - 0.0027 16.1 22.2 0.0027 16.1 22.2 2.1 2 0 0 2 2 2 1 Topoisomerase II-associated protein PAT1 O-antigen_lig PF13425.6 CDI75248.1 - 0.0097 14.7 1.5 0.0097 14.7 1.5 2.1 2 0 0 2 2 2 1 O-antigen ligase like membrane protein SUIM_assoc PF16619.5 CDI75248.1 - 0.018 15.1 7.7 0.018 15.1 7.7 8.7 2 2 1 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 MMR1 PF08505.10 CDI75248.1 - 0.041 14.2 42.9 0.14 12.4 20.0 2.5 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein SLC12 PF03522.15 CDI75248.1 - 3.4 6.6 42.7 0.72 8.8 15.8 2.2 2 0 0 2 2 2 0 Solute carrier family 12 YL1 PF05764.13 CDI75248.1 - 4.5 7.3 44.6 0.2 11.8 17.0 2.2 2 0 0 2 2 2 0 YL1 nuclear protein PA26 PF04636.13 CDI75248.1 - 7.3 5.4 28.1 0.57 9.0 9.8 2.2 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) K_channel_TID PF07941.11 CDI75249.1 - 0.0034 17.8 11.6 0.0034 17.8 11.6 18.3 9 3 6 15 15 15 2 Potassium channel Kv1.4 tandem inactivation domain SR-25 PF10500.9 CDI75250.1 - 0.00053 19.7 97.6 0.00086 19.0 33.0 3.9 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.15 CDI75250.1 - 0.027 15.3 0.9 0.027 15.3 0.9 4.7 3 1 1 4 4 4 0 Chorion family 2 CDC27 PF09507.10 CDI75250.1 - 2 7.7 108.7 0.012 15.0 58.9 2.0 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 RskA PF10099.9 CDI75251.1 - 0.0002 21.7 3.4 0.0002 21.7 3.4 11.3 2 2 6 8 8 4 2 Anti-sigma-K factor rskA AA_permease_2 PF13520.6 CDI75251.1 - 0.00029 19.8 0.6 0.0012 17.8 0.4 1.8 1 1 0 2 2 2 1 Amino acid permease DUF3169 PF11368.8 CDI75251.1 - 0.0051 16.4 0.2 0.0051 16.4 0.2 3.8 4 0 0 4 4 3 1 Protein of unknown function (DUF3169) TFIIA PF03153.13 CDI75251.1 - 0.0061 16.6 15.4 0.0061 16.6 15.4 5.7 2 1 3 5 5 3 1 Transcription factor IIA, alpha/beta subunit DUF4064 PF13273.6 CDI75251.1 - 0.0065 16.7 0.3 0.0065 16.7 0.3 6.7 3 1 4 7 7 5 2 Protein of unknown function (DUF4064) DUF3185 PF11381.8 CDI75251.1 - 0.018 15.0 0.8 12 6.0 0.1 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) CCSAP PF15748.5 CDI75251.1 - 0.021 15.0 0.1 0.021 15.0 0.1 6.9 3 2 3 7 7 5 0 Centriole, cilia and spindle-associated Ac76 PF05814.11 CDI75251.1 - 0.057 13.4 1.4 5.9 7.0 0.0 3.2 2 1 1 3 3 3 0 Orf76 (Ac76) PIP5K PF01504.18 CDI75251.1 - 0.095 11.9 0.1 0.095 11.9 0.1 4.9 4 1 0 5 5 4 0 Phosphatidylinositol-4-phosphate 5-Kinase SARAF PF06682.12 CDI75251.1 - 0.1 12.2 0.0 0.1 12.2 0.0 5.7 3 1 1 5 5 3 0 SOCE-associated regulatory factor of calcium homoeostasis SUR7 PF06687.12 CDI75251.1 - 0.18 11.4 2.2 1.5 8.4 0.5 2.3 2 0 0 2 2 2 0 SUR7/PalI family ABC_export PF16962.5 CDI75251.1 - 0.24 9.8 5.2 1.5 7.2 0.4 2.3 2 0 0 2 2 2 0 Putative ABC exporter 7TM_GPCR_Sru PF10322.9 CDI75251.1 - 5.6 6.2 9.2 0.12 11.7 0.2 2.7 3 0 0 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Sru DUF4149 PF13664.6 CDI75251.1 - 8.2 6.8 10.3 12 6.2 1.8 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4149) WD40 PF00400.32 CDI75252.1 - 5.4e-15 55.5 13.0 5.1e-05 24.0 0.0 7.2 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI75252.1 - 1e-07 32.1 0.0 0.097 13.0 0.0 4.8 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.6 CDI75252.1 - 0.0041 16.4 2.4 0.47 9.7 0.0 3.9 4 1 1 5 5 5 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Ge1_WD40 PF16529.5 CDI75252.1 - 0.011 14.8 0.3 0.035 13.1 0.3 1.8 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SUIM_assoc PF16619.5 CDI75252.1 - 0.036 14.1 0.8 0.036 14.1 0.8 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI75252.1 - 0.077 12.6 3.7 0.17 11.5 3.2 1.7 2 0 0 2 2 2 0 Spt20 family SPX PF03105.19 CDI75252.1 - 1.6 8.5 8.8 20 5.0 8.9 2.3 1 1 0 1 1 1 0 SPX domain Roughex PF06020.11 CDI75252.1 - 1.8 7.6 3.5 3.2 6.8 3.5 1.3 1 0 0 1 1 1 0 Drosophila roughex protein DUF4667 PF15700.5 CDI75253.1 - 4e-05 23.9 1.9 4e-05 23.9 1.9 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4667) Spt20 PF12090.8 CDI75253.1 - 9.7e-05 22.1 7.1 0.00019 21.1 7.1 1.5 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 CDI75253.1 - 0.22 11.5 16.1 0.13 12.2 13.7 1.8 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Secretin_N_2 PF07655.13 CDI75253.1 - 1.3 9.6 35.0 0.089 13.3 10.4 2.6 3 0 0 3 3 3 0 Secretin N-terminal domain RIFIN PF02009.16 CDI75253.1 - 8.6 6.1 11.4 6.6 6.5 4.0 2.9 3 0 0 3 3 3 0 Rifin DUF1645 PF07816.11 CDI75253.1 - 8.8 6.9 25.8 0.22 12.1 5.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1645) DUF4614 PF15391.6 CDI75253.1 - 9.1 6.2 30.0 0.058 13.4 1.8 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4614) TMEM171 PF15471.6 CDI75256.1 - 9.5 5.1 6.3 22 3.9 6.3 1.6 1 0 0 1 1 1 0 Transmembrane protein family 171 PIH1 PF08190.12 CDI75257.1 - 5.3e-14 52.0 0.0 3.3e-13 49.4 0.0 2.1 1 1 1 2 2 2 1 PIH1 N-terminal domain RskA PF10099.9 CDI75258.1 - 3e-05 24.4 21.6 5.2e-05 23.6 3.9 2.2 1 1 1 2 2 2 1 Anti-sigma-K factor rskA PAT1 PF09770.9 CDI75258.1 - 0.0012 17.2 20.9 0.0013 17.1 20.9 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 NPR3 PF03666.13 CDI75258.1 - 0.0076 15.1 8.3 0.0087 14.9 8.3 1.0 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 EPL1 PF10513.9 CDI75258.1 - 0.009 16.4 11.6 0.011 16.1 11.6 1.2 1 0 0 1 1 1 1 Enhancer of polycomb-like Presenilin PF01080.17 CDI75258.1 - 0.0096 14.7 11.9 0.0098 14.7 11.9 1.1 1 0 0 1 1 1 1 Presenilin Spt20 PF12090.8 CDI75258.1 - 0.014 15.1 30.9 0.022 14.4 30.9 1.3 1 0 0 1 1 1 0 Spt20 family TYW3 PF02676.14 CDI75258.1 - 0.03 13.7 4.8 0.036 13.4 4.8 1.1 1 0 0 1 1 1 0 Methyltransferase TYW3 Endostatin PF06482.11 CDI75258.1 - 0.033 13.7 8.2 0.034 13.6 8.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin TFIIA PF03153.13 CDI75258.1 - 0.039 13.9 30.4 0.051 13.6 30.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4746 PF15928.5 CDI75258.1 - 0.051 13.0 11.4 0.058 12.8 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Zip PF02535.22 CDI75258.1 - 0.077 12.2 4.1 0.085 12.1 4.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PA26 PF04636.13 CDI75258.1 - 0.095 11.6 9.9 0.11 11.4 9.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SOBP PF15279.6 CDI75258.1 - 0.1 13.2 12.7 0.12 13.0 12.7 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein DDHD PF02862.17 CDI75258.1 - 0.11 12.6 8.0 0.15 12.2 8.0 1.3 1 0 0 1 1 1 0 DDHD domain DUF3752 PF12572.8 CDI75258.1 - 0.12 12.8 15.4 0.17 12.4 15.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) SCAI PF12070.8 CDI75258.1 - 0.16 10.8 9.4 0.2 10.5 9.4 1.0 1 0 0 1 1 1 0 Protein SCAI Cellulose_synt PF03552.14 CDI75258.1 - 0.17 10.3 1.7 0.18 10.2 1.7 1.0 1 0 0 1 1 1 0 Cellulose synthase PIEZO PF15917.5 CDI75258.1 - 0.2 11.1 15.4 0.23 10.9 15.4 1.1 1 0 0 1 1 1 0 Piezo DUF3340 PF11818.8 CDI75258.1 - 0.21 11.7 15.3 0.27 11.4 15.3 1.1 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) DUF1980 PF09323.10 CDI75258.1 - 0.25 11.2 4.8 0.31 10.9 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) WTX PF09422.10 CDI75258.1 - 0.26 10.3 10.3 0.29 10.1 10.3 1.0 1 0 0 1 1 1 0 WTX protein RR_TM4-6 PF06459.12 CDI75258.1 - 0.3 10.9 14.4 0.35 10.7 14.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PNISR PF15996.5 CDI75258.1 - 0.31 11.3 21.1 0.4 10.9 21.1 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Nop53 PF07767.11 CDI75258.1 - 0.31 10.4 23.1 0.36 10.2 23.1 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Dicty_REP PF05086.12 CDI75258.1 - 0.33 8.9 5.8 0.36 8.7 5.8 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein MMR1 PF08505.10 CDI75258.1 - 0.35 11.1 14.5 0.45 10.8 14.5 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein ALMT PF11744.8 CDI75258.1 - 0.37 9.6 10.6 0.42 9.4 10.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM60A PF15396.6 CDI75258.1 - 0.37 10.7 10.6 0.46 10.4 10.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SpoIIP PF07454.11 CDI75258.1 - 0.45 9.9 13.1 0.6 9.5 13.1 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PsaN PF05479.11 CDI75258.1 - 0.47 10.6 5.2 6 7.1 0.3 2.2 2 0 0 2 2 2 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) LptF_LptG PF03739.14 CDI75258.1 - 0.54 9.1 1.8 0.64 8.8 1.8 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG GREB1 PF15782.5 CDI75258.1 - 0.71 6.9 12.2 0.76 6.8 12.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 CDI75258.1 - 0.85 8.6 14.1 1 8.3 14.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Rtf2 PF04641.12 CDI75258.1 - 0.91 8.8 13.7 1.1 8.5 13.7 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger CDC45 PF02724.14 CDI75258.1 - 0.93 7.7 12.4 1.1 7.5 12.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 CDI75258.1 - 1.1 8.2 8.1 1.2 8.0 8.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SID-1_RNA_chan PF13965.6 CDI75258.1 - 1.1 7.6 4.2 1.1 7.5 4.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GHMP_kinases_N PF00288.26 CDI75258.1 - 1.2 9.4 7.9 0.72 10.1 0.7 2.3 2 0 0 2 2 2 0 GHMP kinases N terminal domain YABBY PF04690.13 CDI75258.1 - 1.2 9.6 11.1 1.7 9.2 11.1 1.2 1 0 0 1 1 1 0 YABBY protein DUF2828 PF11443.8 CDI75258.1 - 1.3 7.0 14.3 1.6 6.7 14.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Menin PF05053.13 CDI75258.1 - 1.3 7.3 9.6 1.7 6.9 9.6 1.2 1 0 0 1 1 1 0 Menin DUF3332 PF11810.8 CDI75258.1 - 1.4 8.6 4.7 1.7 8.3 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) DUF4578 PF15147.6 CDI75258.1 - 1.4 9.8 20.6 2.4 9.1 20.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4578) SpoVR PF04293.13 CDI75258.1 - 1.4 7.5 15.1 1.8 7.1 15.1 1.1 1 0 0 1 1 1 0 SpoVR like protein Otopetrin PF03189.13 CDI75258.1 - 1.5 7.5 6.8 1.7 7.4 6.8 1.1 1 0 0 1 1 1 0 Otopetrin NARP1 PF12569.8 CDI75258.1 - 1.5 7.6 14.9 1.8 7.4 14.9 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CSRNP_N PF16019.5 CDI75258.1 - 1.8 8.4 16.1 2.4 8.0 16.1 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Paramyxo_ncap PF00973.19 CDI75258.1 - 2 7.2 8.4 2.3 7.1 8.4 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Ureide_permease PF07168.11 CDI75258.1 - 2.2 7.0 4.3 2.6 6.7 4.3 1.3 1 0 0 1 1 1 0 Ureide permease Neur_chan_memb PF02932.16 CDI75258.1 - 2.4 8.2 11.0 2.9 7.9 11.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 CDI75258.1 - 2.4 6.2 14.4 2.8 6.0 14.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ndc1_Nup PF09531.10 CDI75258.1 - 2.5 6.7 12.3 2.7 6.6 12.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TERB2 PF15101.6 CDI75258.1 - 2.6 8.1 18.5 3.9 7.5 18.5 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 ArAE_2_N PF10337.9 CDI75258.1 - 2.6 7.0 6.8 3.4 6.6 6.8 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Band_3_cyto PF07565.13 CDI75258.1 - 2.8 7.7 13.3 3.6 7.3 13.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain LMBR1 PF04791.16 CDI75258.1 - 2.9 6.7 6.2 3.1 6.6 6.2 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein ADP_ribosyl_GH PF03747.14 CDI75258.1 - 3.3 7.4 7.0 6.1 6.5 7.0 1.4 1 1 0 1 1 1 0 ADP-ribosylglycohydrolase Gti1_Pac2 PF09729.9 CDI75258.1 - 3.4 7.7 13.9 4.3 7.4 13.9 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family eIF-3_zeta PF05091.12 CDI75258.1 - 4.2 6.2 19.4 5.2 5.9 19.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_S64 PF08192.11 CDI75258.1 - 4.6 5.6 13.3 5.5 5.4 13.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF4179 PF13786.6 CDI75258.1 - 4.8 7.7 8.1 4.9 7.7 2.4 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) DUF4366 PF14283.6 CDI75258.1 - 5.1 7.1 8.2 5.3 7.1 7.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) CSG2 PF16965.5 CDI75258.1 - 5.1 5.9 7.9 6 5.7 7.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator MAJIN PF15077.6 CDI75258.1 - 5.2 6.8 10.3 6.7 6.4 10.3 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Bud13 PF09736.9 CDI75258.1 - 5.3 7.4 24.2 7.3 7.0 24.2 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Membralin PF09746.9 CDI75258.1 - 5.6 5.9 11.6 6.9 5.6 11.6 1.0 1 0 0 1 1 1 0 Tumour-associated protein Adeno_PIX PF03955.14 CDI75258.1 - 5.9 7.1 9.6 3.8 7.7 2.0 2.2 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) Radical_SAM_N PF08497.10 CDI75258.1 - 6.1 6.0 7.7 7.5 5.7 7.7 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal O-antigen_lig PF13425.6 CDI75258.1 - 6.5 5.4 6.2 7.5 5.2 6.2 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Connexin PF00029.19 CDI75258.1 - 7.1 6.3 11.6 10 5.8 11.6 1.3 1 0 0 1 1 1 0 Connexin SelP_N PF04592.14 CDI75258.1 - 8.5 5.7 18.6 12 5.3 18.6 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CLN3 PF02487.17 CDI75258.1 - 8.5 5.3 12.3 11 5.0 12.3 1.1 1 0 0 1 1 1 0 CLN3 protein BAF1_ABF1 PF04684.13 CDI75258.1 - 8.6 5.3 19.8 1.7 7.6 16.2 1.4 1 1 1 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor CEP170_C PF15308.6 CDI75259.1 - 0.18 10.3 5.8 0.2 10.2 5.8 1.0 1 0 0 1 1 1 0 CEP170 C-terminus Collagen PF01391.18 CDI75260.1 - 0.00041 20.1 4.5 0.00041 20.1 4.5 2.3 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) Nucleoporin_FG2 PF15967.5 CDI75260.1 - 2.2 6.7 14.1 2.9 6.3 14.1 1.0 1 0 0 1 1 1 0 Nucleoporin FG repeated region Presenilin PF01080.17 CDI75261.1 - 1.9 7.2 48.1 2.5 6.8 48.1 1.3 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI75262.1 - 0.02 14.7 35.8 0.15 11.8 12.1 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 MRI PF15325.6 CDI75262.1 - 0.05 14.7 4.6 0.05 14.7 4.6 2.9 3 0 0 3 3 3 0 Modulator of retrovirus infection FAM60A PF15396.6 CDI75262.1 - 0.12 12.4 28.5 0.36 10.8 9.4 2.3 2 0 0 2 2 2 0 Protein Family FAM60A CCSAP PF15748.5 CDI75262.1 - 0.16 12.1 41.2 0.32 11.1 14.0 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Vfa1 PF08432.10 CDI75262.1 - 0.24 11.7 41.0 0.17 12.2 16.1 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 NPR3 PF03666.13 CDI75262.1 - 0.65 8.7 27.4 0.19 10.5 8.8 2.3 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 SMYLE_N PF18615.1 CDI75262.1 - 0.8 9.2 36.2 1.3 8.5 14.1 2.1 1 1 1 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Hamartin PF04388.12 CDI75262.1 - 1.3 7.6 37.4 2 7.0 37.4 1.2 1 0 0 1 1 1 0 Hamartin protein AUX_IAA PF02309.16 CDI75262.1 - 5.2 6.9 27.5 2.2 8.1 7.2 2.2 2 0 0 2 2 2 0 AUX/IAA family Presenilin PF01080.17 CDI75262.1 - 8.7 5.0 50.7 0.63 8.7 20.3 2.1 2 0 0 2 2 2 0 Presenilin RsgA_GTPase PF03193.16 CDI75264.1 - 9.5e-05 22.4 0.0 0.00013 22.0 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CDI75264.1 - 0.0023 18.3 0.1 0.0023 18.3 0.1 2.0 1 1 1 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 CDI75264.1 - 0.0061 16.5 0.0 0.0085 16.0 0.0 1.1 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 CDI75264.1 - 0.014 15.7 0.0 0.023 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDI75264.1 - 0.017 14.8 0.4 0.017 14.8 0.4 2.2 1 1 1 2 2 1 0 AAA domain NACHT PF05729.12 CDI75264.1 - 0.027 14.4 0.2 0.041 13.8 0.2 1.3 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 CDI75264.1 - 0.08 13.5 0.1 0.12 12.9 0.1 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDI75264.1 - 0.089 13.3 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 ABC transporter NTPase_1 PF03266.15 CDI75264.1 - 0.22 11.4 0.0 0.3 11.0 0.0 1.1 1 0 0 1 1 1 0 NTPase AAA_33 PF13671.6 CDI75264.1 - 0.36 11.0 3.1 0.43 10.7 0.2 2.1 2 0 0 2 2 2 0 AAA domain DUF4813 PF16072.5 CDI75264.1 - 4.1 7.0 39.2 4.9 6.7 39.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Caldesmon PF02029.15 CDI75265.1 - 0.0016 17.3 58.9 0.0021 16.9 58.9 1.2 1 0 0 1 1 1 1 Caldesmon Dapper PF15268.6 CDI75265.1 - 0.027 13.4 66.3 0.038 12.9 66.3 1.3 1 0 0 1 1 1 0 Dapper Gal4_dimer PF03902.13 CDI75266.1 - 0.053 13.7 0.0 8.4 6.6 0.0 2.7 2 0 0 2 2 2 0 Gal4-like dimerisation domain GT87 PF09594.10 CDI75267.1 - 1.6 8.4 13.0 2.8 7.6 1.1 3.2 3 0 0 3 3 3 0 Glycosyltransferase family 87 SR-25 PF10500.9 CDI75269.1 - 0.0019 17.8 19.1 0.0021 17.7 19.1 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CCSAP PF15748.5 CDI75269.1 - 1.9 8.6 24.1 2.1 8.4 24.1 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated EFTUD2 PF16004.5 CDI75269.1 - 1.9 9.0 19.2 2.3 8.8 19.2 1.1 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Spc7_N PF15402.6 CDI75269.1 - 2.4 6.3 22.4 2.4 6.3 22.4 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Pex14_N PF04695.13 CDI75269.1 - 5.3 7.7 30.0 5.6 7.6 30.0 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region STAC2_u1 PF16664.5 CDI75269.1 - 6.6 7.2 17.5 7.8 7.0 17.5 1.1 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 DUF4175 PF13779.6 CDI75269.1 - 6.9 4.4 35.9 7.5 4.3 35.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SelP_N PF04592.14 CDI75269.1 - 7 6.0 21.8 7.3 5.9 21.8 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Gti1_Pac2 PF09729.9 CDI75269.1 - 7.4 6.6 20.4 8 6.5 20.4 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family FAM150 PF15129.6 CDI75269.1 - 8 6.6 16.6 8.7 6.5 16.6 1.2 1 0 0 1 1 1 0 FAM150 family TCP PF03634.13 CDI75269.1 - 8.2 7.0 22.8 8.7 6.9 22.8 1.1 1 0 0 1 1 1 0 TCP family transcription factor DUF4820 PF16091.5 CDI75269.1 - 8.5 5.7 17.4 10 5.4 17.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) NARP1 PF12569.8 CDI75269.1 - 8.8 5.1 20.4 9.1 5.1 20.4 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Eapp_C PF10238.9 CDI75269.1 - 9.2 6.3 20.2 11 6.1 20.2 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein Kinase-like PF14531.6 CDI75270.1 - 0.0019 17.6 0.0 0.017 14.4 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase PF00069.25 CDI75270.1 - 0.06 12.7 0.0 0.09 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Pkinase PF00069.25 CDI75271.1 - 3.1e-12 46.4 0.0 8.7e-11 41.7 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.6 CDI75271.1 - 5.3e-06 26.0 0.0 9.3e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 CDI75271.1 - 1.3e-05 24.6 0.0 5e-05 22.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Solute_trans_a PF03619.16 CDI75272.1 - 1.1e-13 51.3 0.1 2.7e-08 33.7 0.1 2.3 2 0 0 2 2 2 2 Organic solute transporter Ostalpha Rib_recp_KP_reg PF05104.12 CDI75273.1 - 0.0022 19.0 22.3 0.0022 19.0 22.3 6.0 4 2 2 7 7 7 2 Ribosome receptor lysine/proline rich region Pro_isomerase PF00160.21 CDI75274.1 - 3.4e-26 92.4 0.0 1.8e-22 80.3 0.0 2.1 1 1 1 2 2 2 2 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Kinase-like PF14531.6 CDI75275.1 - 3.2e-05 23.4 0.0 6.3e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 CDI75275.1 - 0.00042 19.7 0.0 0.00067 19.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDI75275.1 - 0.0019 17.6 0.0 0.0027 17.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DnaJ PF00226.31 CDI75276.1 - 4e-33 113.3 4.5 3.2e-23 81.6 1.0 2.3 2 0 0 2 2 2 2 DnaJ domain DUF4278 PF14105.6 CDI75276.1 - 0.03 14.8 0.0 0.38 11.2 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4278) Cdc6_C PF09079.11 CDI75276.1 - 0.17 11.9 2.6 29 4.7 0.0 3.6 2 1 2 4 4 4 0 CDC6, C terminal winged helix domain RuvX PF03652.15 CDI75277.1 - 1.4e-07 32.0 3.5 0.00025 21.4 0.0 3.7 3 1 0 3 3 3 2 Holliday junction resolvase BORG_CEP PF14957.6 CDI75277.1 - 2.9 9.0 14.4 3.5 8.8 7.4 2.7 3 0 0 3 3 3 0 Cdc42 effector DUF4179 PF13786.6 CDI75277.1 - 6.3 7.3 19.0 38 4.8 0.0 3.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4179) Hid1 PF12722.7 CDI75277.1 - 8.2 4.4 14.0 13 3.8 14.0 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDK2AP PF09806.9 CDI75278.1 - 0.83 9.7 9.5 0.9 9.6 9.5 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DUF4131 PF13567.6 CDI75279.1 - 0.002 17.8 0.1 0.0023 17.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) DUF3506 PF12014.8 CDI75279.1 - 0.044 13.8 0.9 0.061 13.3 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3506) Nuf2 PF03800.14 CDI75279.1 - 0.11 12.7 2.9 0.11 12.6 2.9 1.2 1 0 0 1 1 1 0 Nuf2 family EphA2_TM PF14575.6 CDI75279.1 - 1 10.3 5.3 23 5.9 5.3 2.0 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain OPA3 PF07047.12 CDI75279.1 - 1.9 8.3 6.3 1.1 9.0 4.6 1.5 2 0 0 2 2 2 0 Optic atrophy 3 protein (OPA3) YajC PF02699.15 CDI75279.1 - 2.2 8.2 12.3 2.1 8.3 4.0 2.3 2 0 0 2 2 2 0 Preprotein translocase subunit Spt20 PF12090.8 CDI75280.1 - 0.0009 18.9 31.9 0.0009 18.9 31.9 4.0 3 2 0 3 3 1 1 Spt20 family Presenilin PF01080.17 CDI75280.1 - 0.013 14.3 19.5 0.036 12.8 12.4 2.7 2 0 0 2 2 2 0 Presenilin TYW3 PF02676.14 CDI75280.1 - 0.032 13.6 8.0 1.5 8.2 4.5 2.6 2 0 0 2 2 2 0 Methyltransferase TYW3 BSP_II PF05432.11 CDI75280.1 - 0.3 10.7 10.4 0.69 9.6 10.4 1.5 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Vfa1 PF08432.10 CDI75280.1 - 0.65 10.3 22.3 2.1 8.7 1.1 2.8 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF4746 PF15928.5 CDI75280.1 - 1.4 8.2 23.5 0.38 10.1 12.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Tim54 PF11711.8 CDI75280.1 - 2.7 6.7 18.1 0.49 9.1 11.0 2.3 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 PPP4R2 PF09184.11 CDI75280.1 - 3 7.4 19.5 18 4.8 17.6 2.4 2 1 0 2 2 2 0 PPP4R2 PA26 PF04636.13 CDI75280.1 - 6 5.7 19.7 2.1 7.2 10.5 2.4 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) RNA_pol_3_Rpc31 PF11705.8 CDI75280.1 - 7 6.8 18.9 0.82 9.9 8.6 2.8 2 1 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 CLN3 PF02487.17 CDI75280.1 - 9.4 5.2 15.9 9.9 5.1 0.4 2.4 2 0 0 2 2 2 0 CLN3 protein SPX PF03105.19 CDI75281.1 - 0.044 13.7 5.6 0.054 13.4 5.6 1.1 1 0 0 1 1 1 0 SPX domain PAP1 PF08601.10 CDI75281.1 - 3.4 7.3 16.5 5.2 6.7 16.5 1.3 1 1 0 1 1 1 0 Transcription factor PAP1 DUF1635 PF07795.11 CDI75281.1 - 5.8 6.7 9.6 8.3 6.2 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Pap_E4 PF02711.14 CDI75281.1 - 6.8 7.7 7.3 39 5.3 7.3 2.2 1 1 0 1 1 1 0 E4 protein TFIIA PF03153.13 CDI75281.1 - 9.8 6.1 15.6 13 5.7 15.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3395 PF11875.8 CDI75282.1 - 3.7e-20 72.4 0.0 6.5e-20 71.6 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3395) SUIM_assoc PF16619.5 CDI75284.1 - 0.00041 20.4 4.7 0.00041 20.4 4.7 10.3 5 4 2 8 8 8 1 Unstructured region C-term to UIM in Ataxin3 SPX PF03105.19 CDI75284.1 - 0.0053 16.7 16.2 0.0053 16.7 16.2 4.1 1 1 2 4 4 4 1 SPX domain DSPc PF00782.20 CDI75286.1 - 1.2e-05 25.2 0.1 1.2e-05 25.2 0.1 3.6 4 1 0 4 4 4 1 Dual specificity phosphatase, catalytic domain Drc1-Sld2 PF11719.8 CDI75286.1 - 0.0011 18.6 16.6 0.0011 18.6 16.6 6.4 5 1 1 6 6 6 2 DNA replication and checkpoint protein DUF2828 PF11443.8 CDI75286.1 - 0.0019 16.4 15.4 0.0019 16.4 15.4 6.0 6 1 0 6 6 6 1 Domain of unknown function (DUF2828) CAC1F_C PF16885.5 CDI75286.1 - 0.0027 17.5 10.5 0.0027 17.5 10.5 6.0 5 1 1 6 6 6 1 Voltage-gated calcium channel subunit alpha, C-term RR_TM4-6 PF06459.12 CDI75286.1 - 0.0047 16.8 13.4 0.0047 16.8 13.4 7.0 6 1 0 6 6 6 4 Ryanodine Receptor TM 4-6 DUF4148 PF13663.6 CDI75286.1 - 0.0048 17.1 37.6 0.063 13.5 0.8 7.8 7 0 0 7 7 7 3 Domain of unknown function (DUF4148) Y_phosphatase3 PF13350.6 CDI75286.1 - 0.0067 16.4 0.0 0.0067 16.4 0.0 4.7 6 1 0 6 6 6 1 Tyrosine phosphatase family Tim54 PF11711.8 CDI75287.1 - 0.001 17.9 3.2 0.001 17.9 3.2 6.6 5 3 0 5 5 5 1 Inner membrane protein import complex subunit Tim54 Pkinase PF00069.25 CDI75288.1 - 5.6e-12 45.6 0.0 5.6e-12 45.6 0.0 2.0 1 1 1 2 2 1 1 Protein kinase domain DDHD PF02862.17 CDI75288.1 - 0.0019 18.4 3.4 0.0019 18.4 3.4 1.1 1 0 0 1 1 1 1 DDHD domain RskA PF10099.9 CDI75288.1 - 0.0099 16.2 11.1 0.016 15.5 11.1 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Folate_carrier PF01770.18 CDI75288.1 - 0.023 13.5 4.2 0.028 13.2 4.2 1.1 1 0 0 1 1 1 0 Reduced folate carrier OATP PF03137.20 CDI75288.1 - 0.024 13.0 3.3 0.034 12.4 3.3 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SelP_N PF04592.14 CDI75288.1 - 0.027 13.9 24.2 0.031 13.7 24.2 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CD20 PF04103.15 CDI75288.1 - 0.038 14.1 0.2 0.049 13.7 0.2 1.2 1 0 0 1 1 1 0 CD20-like family Ndc1_Nup PF09531.10 CDI75288.1 - 0.041 12.6 4.1 0.04 12.6 4.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup EPL1 PF10513.9 CDI75288.1 - 0.046 14.1 7.8 0.054 13.9 7.8 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like Peptidase_S64 PF08192.11 CDI75288.1 - 0.049 12.1 4.8 0.048 12.1 4.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 Phage_GPD PF05954.11 CDI75288.1 - 0.052 12.8 13.9 0.062 12.6 13.9 1.0 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) DUF719 PF05334.13 CDI75288.1 - 0.056 13.6 12.4 0.076 13.2 12.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF719) O-antigen_lig PF13425.6 CDI75288.1 - 0.09 11.6 1.8 0.11 11.3 1.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Pex14_N PF04695.13 CDI75288.1 - 0.12 13.1 23.6 0.14 12.8 23.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Suf PF05843.14 CDI75288.1 - 0.15 12.1 16.2 0.16 11.9 16.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ctr PF04145.15 CDI75288.1 - 0.17 12.5 6.9 0.24 12.0 6.9 1.2 1 0 0 1 1 1 0 Ctr copper transporter family DUF1980 PF09323.10 CDI75288.1 - 0.22 11.4 8.1 0.29 11.0 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Med15 PF09606.10 CDI75288.1 - 0.25 10.0 27.6 0.3 9.7 27.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2956 PF11169.8 CDI75288.1 - 0.3 11.3 20.0 0.38 11.0 20.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) DUF4770 PF15994.5 CDI75288.1 - 0.32 11.2 10.1 0.4 10.9 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) R_equi_Vir PF05526.11 CDI75288.1 - 0.37 10.6 10.7 0.46 10.3 10.7 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein CHGN PF05679.16 CDI75288.1 - 0.39 9.5 13.6 0.45 9.3 13.6 1.0 1 0 0 1 1 1 0 Chondroitin N-acetylgalactosaminyltransferase BORG_CEP PF14957.6 CDI75288.1 - 0.4 11.9 5.4 0.49 11.6 5.4 1.1 1 0 0 1 1 1 0 Cdc42 effector FAM176 PF14851.6 CDI75288.1 - 0.43 10.2 3.9 0.62 9.7 3.9 1.3 1 0 0 1 1 1 0 FAM176 family Connexin PF00029.19 CDI75288.1 - 0.46 10.2 8.5 0.54 10.0 8.5 1.1 1 0 0 1 1 1 0 Connexin DUF2722 PF10846.8 CDI75288.1 - 0.55 9.1 26.4 0.71 8.8 26.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Wzz PF02706.15 CDI75288.1 - 0.64 10.4 5.7 1.1 9.7 5.7 1.4 1 0 0 1 1 1 0 Chain length determinant protein PAT1 PF09770.9 CDI75288.1 - 0.67 8.2 24.9 0.72 8.1 24.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TERB2 PF15101.6 CDI75288.1 - 0.68 10.0 18.6 0.94 9.5 18.6 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Radical_SAM_N PF08497.10 CDI75288.1 - 0.74 9.0 6.4 0.77 8.9 6.4 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal CLN3 PF02487.17 CDI75288.1 - 0.84 8.6 7.1 0.94 8.4 7.1 1.1 1 0 0 1 1 1 0 CLN3 protein Gti1_Pac2 PF09729.9 CDI75288.1 - 0.99 9.5 8.9 1.3 9.1 8.9 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Peptidase_S49_N PF08496.10 CDI75288.1 - 1 9.4 9.2 1.3 9.0 9.2 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SID-1_RNA_chan PF13965.6 CDI75288.1 - 1.1 7.6 4.8 1.3 7.4 4.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 eIF-3_zeta PF05091.12 CDI75288.1 - 1.2 8.1 16.5 1.3 7.9 16.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Sec62 PF03839.16 CDI75288.1 - 1.3 8.5 7.1 1.6 8.2 7.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 AIF_C PF14721.6 CDI75288.1 - 1.6 9.1 9.6 2.4 8.5 9.6 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term IHABP4_N PF16174.5 CDI75288.1 - 1.7 9.2 16.8 2.5 8.7 16.8 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal TFIIA PF03153.13 CDI75288.1 - 1.8 8.5 37.8 2.2 8.2 37.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glt_symporter PF03616.14 CDI75288.1 - 1.9 7.1 4.8 2.8 6.5 4.8 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter DUF2232 PF09991.9 CDI75288.1 - 2.4 7.3 5.6 2.9 7.0 5.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DUF4175 PF13779.6 CDI75288.1 - 2.6 5.8 25.6 3.1 5.6 25.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Coilin_N PF15862.5 CDI75288.1 - 2.9 7.7 13.5 3.9 7.3 13.5 1.3 1 0 0 1 1 1 0 Coilin N-terminus EOS1 PF12326.8 CDI75288.1 - 2.9 7.8 7.7 4 7.3 7.7 1.2 1 0 0 1 1 1 0 N-glycosylation protein Velvet PF11754.8 CDI75288.1 - 3.1 7.6 16.6 3.9 7.3 16.6 1.1 1 0 0 1 1 1 0 Velvet factor DUF2828 PF11443.8 CDI75288.1 - 3.2 5.7 12.2 3.7 5.5 12.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Neur_chan_memb PF02932.16 CDI75288.1 - 3.7 7.5 11.2 4.1 7.4 11.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HA2 PF04408.23 CDI75288.1 - 4 7.8 7.7 2.9 8.2 5.7 1.8 2 0 0 2 2 1 0 Helicase associated domain (HA2) Serinc PF03348.15 CDI75288.1 - 4.2 6.2 10.5 5 5.9 10.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) MDM10 PF12519.8 CDI75288.1 - 4.3 6.1 9.4 4.8 5.9 9.4 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CSG2 PF16965.5 CDI75288.1 - 4.7 6.1 6.6 5.4 5.8 6.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Presenilin PF01080.17 CDI75288.1 - 5 5.8 19.4 5.6 5.6 19.4 1.1 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 CDI75288.1 - 5.1 4.9 13.6 5.6 4.8 13.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SLC12 PF03522.15 CDI75288.1 - 5.3 6.0 13.0 6.2 5.7 13.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Paf1 PF03985.13 CDI75288.1 - 5.3 5.9 14.8 6.2 5.7 14.8 1.0 1 0 0 1 1 1 0 Paf1 CPSF100_C PF13299.6 CDI75288.1 - 6.1 7.0 10.4 8.6 6.5 10.4 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal BAF1_ABF1 PF04684.13 CDI75288.1 - 6.3 5.7 17.9 7.3 5.5 17.9 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor EIF4E-T PF10477.9 CDI75288.1 - 6.3 5.5 26.1 7.9 5.2 26.1 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Zip PF02535.22 CDI75288.1 - 6.6 5.8 11.6 8.2 5.5 11.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Band_3_cyto PF07565.13 CDI75288.1 - 6.6 6.5 12.7 7.9 6.2 12.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FAM60A PF15396.6 CDI75288.1 - 6.8 6.6 11.6 8.4 6.3 11.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Ureide_permease PF07168.11 CDI75288.1 - 7.5 5.2 6.4 9.4 4.9 6.4 1.1 1 0 0 1 1 1 0 Ureide permease Paramyxo_ncap PF00973.19 CDI75288.1 - 7.9 5.3 12.7 9.3 5.0 12.7 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein ALMT PF11744.8 CDI75288.1 - 9.1 5.0 10.4 10 4.8 10.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter EMC3_TMCO1 PF01956.16 CDI75288.1 - 9.5 5.9 8.1 12 5.6 8.1 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like CDC27 PF09507.10 CDI75291.1 - 8.7 5.6 7.3 9.2 5.5 7.3 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SOG2 PF10428.9 CDI75293.1 - 0.029 13.6 25.8 0.038 13.2 25.8 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein DUF4551 PF15087.6 CDI75293.1 - 0.1 11.4 25.6 0.14 11.0 25.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Sporozoite_P67 PF05642.11 CDI75293.1 - 1.6 6.7 27.5 0.66 8.0 24.8 1.6 2 0 0 2 2 2 0 Sporozoite P67 surface antigen MDMPI_N PF11716.8 CDI75294.1 - 0.6 10.8 28.4 0.77 10.4 28.4 1.0 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain DUF2722 PF10846.8 CDI75295.1 - 0.00011 21.3 0.4 0.00011 21.3 0.4 17.5 15 2 0 15 15 15 7 Protein of unknown function (DUF2722) DUF1059 PF06348.11 CDI75295.1 - 0.028 14.6 0.1 0.087 13.1 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1059) RskA PF10099.9 CDI75295.1 - 0.21 11.8 0.0 0.21 11.8 0.0 23.1 7 5 11 19 19 19 0 Anti-sigma-K factor rskA PAP1 PF08601.10 CDI75297.1 - 3.6e-05 23.7 0.4 3.6e-05 23.7 0.4 14.2 10 4 1 12 12 12 1 Transcription factor PAP1 ANAPC1 PF12859.7 CDI75297.1 - 0.00029 21.4 2.8 0.00029 21.4 2.8 16.8 14 5 1 15 15 15 2 Anaphase-promoting complex subunit 1 Shadoo PF14999.6 CDI75297.1 - 0.0016 18.6 4.2 0.0016 18.6 4.2 22.9 20 2 2 22 22 22 1 Shadow of prion protein, neuroprotective DUF4207 PF13904.6 CDI75297.1 - 0.0034 17.1 13.1 0.0034 17.1 13.1 19.0 17 4 1 18 18 18 4 Domain of unknown function (DUF4207) RskA PF10099.9 CDI75302.1 - 0.0005 20.4 15.2 0.00064 20.1 15.2 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Roughex PF06020.11 CDI75302.1 - 0.06 12.4 11.3 0.073 12.2 11.3 1.2 1 0 0 1 1 1 0 Drosophila roughex protein PI3K_1B_p101 PF10486.9 CDI75302.1 - 0.14 9.9 15.6 0.13 10.0 15.6 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Macoilin PF09726.9 CDI75302.1 - 0.2 10.2 30.6 0.23 10.0 30.6 1.0 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI75302.1 - 0.53 10.2 32.0 0.62 10.0 32.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PA26 PF04636.13 CDI75302.1 - 3.7 6.4 14.0 4.2 6.2 14.0 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CRT10 PF08728.10 CDI75302.1 - 5.5 5.0 15.3 5.7 5.0 15.3 1.0 1 0 0 1 1 1 0 CRT10 Menin PF05053.13 CDI75302.1 - 5.6 5.2 25.2 6.9 4.9 25.2 1.1 1 0 0 1 1 1 0 Menin CAML PF14963.6 CDI75302.1 - 5.8 7.0 15.7 6.4 6.8 15.7 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand NEMP PF10225.9 CDI75302.1 - 6.4 6.4 9.1 7.9 6.1 9.1 1.2 1 0 0 1 1 1 0 NEMP family PAP1 PF08601.10 CDI75302.1 - 8.2 6.0 36.9 10 5.8 36.9 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 SR-25 PF10500.9 CDI75303.1 - 2.8e-05 23.9 12.8 3.3e-05 23.6 12.8 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Ski2_N PF17911.1 CDI75303.1 - 0.00017 21.4 5.2 0.0002 21.2 5.2 1.1 1 0 0 1 1 1 1 Ski2 N-terminal region TIP_N PF12457.8 CDI75303.1 - 0.0058 17.0 9.8 0.0072 16.7 9.8 1.0 1 0 0 1 1 1 1 Tuftelin interacting protein N terminal Chorion_2 PF03964.15 CDI75303.1 - 0.0072 17.1 7.9 0.0085 16.9 7.9 1.1 1 0 0 1 1 1 1 Chorion family 2 Myc_N PF01056.18 CDI75303.1 - 0.026 14.4 6.3 0.031 14.2 6.3 1.1 1 0 0 1 1 1 0 Myc amino-terminal region MID_MedPIWI PF18296.1 CDI75303.1 - 0.027 14.3 4.5 0.028 14.2 4.5 1.0 1 0 0 1 1 1 0 MID domain of medPIWI Cwf_Cwc_15 PF04889.12 CDI75303.1 - 0.028 14.2 6.9 0.034 13.9 6.9 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TCP PF03634.13 CDI75303.1 - 0.032 14.8 6.1 0.037 14.6 6.1 1.0 1 0 0 1 1 1 0 TCP family transcription factor Herpes_pp85 PF04637.12 CDI75303.1 - 0.089 11.2 3.2 0.091 11.2 3.2 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Spt20 PF12090.8 CDI75303.1 - 0.1 12.2 12.0 0.11 12.1 12.0 1.1 1 0 0 1 1 1 0 Spt20 family CDK2AP PF09806.9 CDI75303.1 - 0.12 12.4 7.4 0.14 12.2 7.4 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein CCDC106 PF15794.5 CDI75303.1 - 0.18 11.5 6.7 0.23 11.2 6.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 PA26 PF04636.13 CDI75303.1 - 0.2 10.6 3.2 0.2 10.5 3.2 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CCSAP PF15748.5 CDI75303.1 - 0.22 11.7 10.1 0.24 11.5 10.1 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CobT PF06213.12 CDI75303.1 - 0.3 10.4 10.9 0.34 10.3 10.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PPP4R2 PF09184.11 CDI75303.1 - 0.73 9.4 8.7 0.86 9.1 8.7 1.0 1 0 0 1 1 1 0 PPP4R2 Sox_N PF12444.8 CDI75303.1 - 0.78 10.9 13.9 1.3 10.2 13.9 1.4 1 0 0 1 1 1 0 Sox developmental protein N terminal DUF3446 PF11928.8 CDI75303.1 - 1.1 9.6 17.5 1.4 9.2 17.5 1.3 1 1 0 1 1 1 0 Early growth response N-terminal domain Presenilin PF01080.17 CDI75303.1 - 5.4 5.7 10.5 6.5 5.4 10.5 1.0 1 0 0 1 1 1 0 Presenilin DUF4614 PF15391.6 CDI75303.1 - 7.4 6.5 16.4 8.6 6.3 16.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) TFIIA PF03153.13 CDI75304.1 - 0.00062 19.9 57.8 0.00062 19.9 57.8 3.5 3 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI75304.1 - 0.0024 16.6 5.1 0.0024 16.6 5.1 3.8 3 1 1 4 4 4 2 ARC105 or Med15 subunit of Mediator complex non-fungal DUF5349 PF17298.2 CDI75304.1 - 0.009 15.8 2.5 0.009 15.8 2.5 4.4 4 1 0 4 4 4 1 Family of unknown function (DUF5349) RskA PF10099.9 CDI75304.1 - 8 6.7 55.5 0.031 14.6 8.7 5.0 4 1 1 5 5 5 0 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI75305.1 - 0.037 12.8 45.0 0.011 14.5 36.5 2.1 2 0 0 2 2 2 0 Presenilin Peptidase_S64 PF08192.11 CDI75305.1 - 0.061 11.8 24.8 0.071 11.6 24.8 1.3 1 0 0 1 1 1 0 Peptidase family S64 Pkinase_fungal PF17667.1 CDI75305.1 - 0.23 10.2 11.7 0.28 9.9 11.7 1.2 1 0 0 1 1 1 0 Fungal protein kinase ASC PF00858.24 CDI75305.1 - 5.4 5.9 21.0 9 5.1 21.0 1.3 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel CRT10 PF08728.10 CDI75305.1 - 7.5 4.6 14.6 7.2 4.6 14.6 1.1 1 0 0 1 1 1 0 CRT10 DUF4638 PF15472.6 CDI75305.1 - 8 6.1 27.7 17 5.0 27.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Membralin PF09746.9 CDI75305.1 - 9.9 5.1 23.3 1.1 8.2 19.4 1.4 2 0 0 2 2 2 0 Tumour-associated protein RskA PF10099.9 CDI75306.1 - 0.0004 20.7 14.9 0.0004 20.7 14.9 5.0 3 2 1 4 4 4 2 Anti-sigma-K factor rskA DUF913 PF06025.12 CDI75306.1 - 0.0039 16.2 44.9 0.017 14.1 7.2 3.1 3 0 0 3 3 3 2 Domain of Unknown Function (DUF913) eIF-3_zeta PF05091.12 CDI75306.1 - 0.0073 15.3 21.1 0.0073 15.3 21.1 3.3 2 1 0 3 3 3 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Methyltransf_32 PF13679.6 CDI75306.1 - 0.014 15.4 13.7 0.014 15.4 13.7 4.0 2 1 0 2 2 2 0 Methyltransferase domain DUF3824 PF12868.7 CDI75306.1 - 0.027 15.1 6.9 0.027 15.1 6.9 7.4 6 2 0 6 6 6 0 Domain of unknwon function (DUF3824) MotB_plug PF13677.6 CDI75306.1 - 4.8 6.9 5.5 3.9 7.2 0.1 3.6 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB OATP PF03137.20 CDI75306.1 - 8.6 4.5 35.7 0.73 8.0 1.7 3.5 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Drc1-Sld2 PF11719.8 CDI75307.1 - 0.0021 17.7 33.6 0.0023 17.6 33.6 1.0 1 0 0 1 1 1 1 DNA replication and checkpoint protein CDC45 PF02724.14 CDI75307.1 - 0.078 11.3 41.7 0.097 11.0 41.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Apt1 PF10351.9 CDI75307.1 - 0.1 11.4 23.1 0.12 11.2 23.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain BUD22 PF09073.10 CDI75307.1 - 0.18 11.1 38.5 0.21 10.9 38.5 1.1 1 0 0 1 1 1 0 BUD22 Suf PF05843.14 CDI75307.1 - 0.33 10.9 36.8 0.44 10.5 36.8 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4045 PF13254.6 CDI75307.1 - 0.68 9.5 33.8 0.93 9.1 33.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SWI-SNF_Ssr4 PF08549.10 CDI75307.1 - 1.2 7.7 37.9 1.4 7.5 37.9 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) SLC12 PF03522.15 CDI75307.1 - 1.4 7.8 40.2 1.9 7.4 40.2 1.2 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI75307.1 - 1.8 6.7 46.5 2.1 6.5 46.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Dapper PF15268.6 CDI75307.1 - 1.8 7.3 38.7 1.9 7.2 38.7 1.0 1 0 0 1 1 1 0 Dapper LAP1C PF05609.12 CDI75307.1 - 1.9 7.5 39.5 2.3 7.2 39.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GAGA_bind PF06217.12 CDI75307.1 - 2 8.6 28.6 2.7 8.2 28.6 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family CDC27 PF09507.10 CDI75307.1 - 2.3 7.5 44.1 3.2 7.0 44.1 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Cwf_Cwc_15 PF04889.12 CDI75307.1 - 4.4 7.0 48.9 5.5 6.7 48.9 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Ndc1_Nup PF09531.10 CDI75307.1 - 6.1 5.4 26.9 6.9 5.2 26.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Membralin PF09746.9 CDI75307.1 - 7.4 5.5 28.8 12 4.8 28.8 1.3 1 0 0 1 1 1 0 Tumour-associated protein Macoilin PF09726.9 CDI75310.1 - 0.0018 17.0 10.2 0.0028 16.3 10.2 1.2 1 0 0 1 1 1 1 Macoilin family VIT1 PF01988.19 CDI75310.1 - 0.25 11.2 1.5 0.72 9.7 1.5 1.8 1 1 0 1 1 1 0 VIT family DAP10 PF07213.11 CDI75311.1 - 1.2 9.1 3.2 6.5 6.8 0.3 2.5 2 0 0 2 2 2 0 DAP10 membrane protein GAGA_bind PF06217.12 CDI75312.1 - 1 9.6 13.2 1.9 8.7 13.2 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family SUIM_assoc PF16619.5 CDI75313.1 - 0.017 15.2 9.3 0.017 15.2 9.3 5.0 2 1 2 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 Trp_oprn_chp PF09534.10 CDI75315.1 - 0.00045 20.1 5.9 0.00045 20.1 5.9 2.2 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SR-25 PF10500.9 CDI75315.1 - 0.0013 18.4 0.8 0.0013 18.4 0.8 2.2 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein PAT1 PF09770.9 CDI75315.1 - 0.0075 14.6 19.5 0.0074 14.6 19.5 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Macoilin PF09726.9 CDI75315.1 - 0.0082 14.8 15.9 0.011 14.3 15.9 1.1 1 0 0 1 1 1 1 Macoilin family SUIM_assoc PF16619.5 CDI75315.1 - 0.023 14.8 8.3 0.023 14.8 8.3 3.9 3 1 0 3 3 1 0 Unstructured region C-term to UIM in Ataxin3 SYF2 PF08231.12 CDI75315.1 - 0.044 14.2 6.8 0.064 13.6 6.8 1.4 1 0 0 1 1 1 0 SYF2 splicing factor RR_TM4-6 PF06459.12 CDI75315.1 - 0.086 12.7 10.6 0.15 11.9 10.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sulf_transp PF04143.14 CDI75315.1 - 0.12 11.9 8.7 0.042 13.4 4.2 1.9 1 1 1 2 2 2 0 Sulphur transport DUF4667 PF15700.5 CDI75315.1 - 0.14 12.3 25.0 0.84 9.7 10.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) Cytochrom_C_asm PF01578.20 CDI75315.1 - 0.14 11.9 0.9 0.76 9.5 0.1 2.1 2 0 0 2 2 2 0 Cytochrome C assembly protein Tim54 PF11711.8 CDI75315.1 - 0.22 10.3 5.7 0.35 9.6 5.7 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SART-1 PF03343.13 CDI75315.1 - 0.23 10.0 13.4 0.29 9.7 13.4 1.1 1 0 0 1 1 1 0 SART-1 family DUF2434 PF10361.9 CDI75315.1 - 0.24 10.4 4.5 0.36 9.8 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2434) DUF2072 PF09845.9 CDI75315.1 - 0.3 11.4 4.0 0.59 10.4 4.0 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein BORG_CEP PF14957.6 CDI75315.1 - 0.4 11.8 12.3 0.45 11.7 5.5 2.2 2 0 0 2 2 2 0 Cdc42 effector MMADHC PF10229.9 CDI75315.1 - 0.62 9.8 11.2 1.1 9.0 11.2 1.3 1 0 0 1 1 1 0 Methylmalonic aciduria and homocystinuria type D protein CcmF_C PF16327.5 CDI75315.1 - 0.79 8.9 3.7 1.3 8.3 3.7 1.4 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal DUF3337 PF11816.8 CDI75315.1 - 0.83 9.5 7.4 1.5 8.6 7.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) SARAF PF06682.12 CDI75315.1 - 1 9.0 21.2 0.24 11.0 7.5 2.2 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis HCO3_cotransp PF00955.21 CDI75315.1 - 1.4 7.6 4.8 2.2 7.0 4.8 1.2 1 0 0 1 1 1 0 HCO3- transporter family DUF2126 PF09899.9 CDI75315.1 - 1.5 6.8 8.5 2.1 6.3 8.5 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Sin_N PF04801.13 CDI75315.1 - 1.6 7.8 25.1 2.6 7.2 25.1 1.3 1 0 0 1 1 1 0 Sin-like protein conserved region Utp14 PF04615.13 CDI75315.1 - 1.8 7.1 18.1 2.6 6.5 18.1 1.1 1 0 0 1 1 1 0 Utp14 protein V_ATPase_I PF01496.19 CDI75315.1 - 1.8 6.4 13.0 2.9 5.7 13.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RIFIN PF02009.16 CDI75315.1 - 2 8.2 13.8 4 7.3 13.8 1.5 1 0 0 1 1 1 0 Rifin RskA PF10099.9 CDI75315.1 - 2.4 8.4 53.6 0.066 13.5 25.4 2.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA MAT1 PF06391.13 CDI75315.1 - 3.9 7.3 21.6 0.3 10.9 16.8 1.6 2 0 0 2 2 1 0 CDK-activating kinase assembly factor MAT1 DUF2681 PF10883.8 CDI75315.1 - 4.2 7.8 36.1 4.5 7.7 21.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DAG_kinase_N PF14513.6 CDI75315.1 - 4.4 7.5 16.1 2.3 8.4 10.8 2.1 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus CD20 PF04103.15 CDI75315.1 - 5.4 7.1 9.0 0.77 9.8 0.3 2.6 2 1 0 2 2 2 0 CD20-like family CLN3 PF02487.17 CDI75315.1 - 5.8 5.8 9.0 12 4.8 8.8 1.6 2 0 0 2 2 2 0 CLN3 protein CSG2 PF16965.5 CDI75315.1 - 6.1 5.7 7.3 2.4 7.0 4.5 1.6 2 0 0 2 2 2 0 Ceramide synthase regulator MMU163 PF17119.5 CDI75315.1 - 6.3 5.9 10.4 5.9 6.0 4.9 2.2 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis TMEM164 PF14808.6 CDI75315.1 - 6.3 6.0 5.8 10 5.3 5.3 1.5 1 1 0 1 1 1 0 TMEM164 family CAF1 PF04857.20 CDI75315.1 - 6.9 5.7 11.5 0.78 8.9 7.3 1.5 2 0 0 2 2 2 0 CAF1 family ribonuclease EphA2_TM PF14575.6 CDI75315.1 - 9.2 7.2 18.1 0.72 10.8 5.3 3.3 2 1 1 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain SPX PF03105.19 CDI75316.1 - 0.00083 19.4 5.1 0.00083 19.4 5.1 4.2 2 2 1 3 3 3 1 SPX domain DUF4207 PF13904.6 CDI75316.1 - 0.0023 17.7 7.8 0.0023 17.7 7.8 7.7 5 2 2 7 7 7 2 Domain of unknown function (DUF4207) SARAF PF06682.12 CDI75318.1 - 8.8e-06 25.6 15.1 1.4e-05 24.9 0.0 2.5 2 1 0 2 2 1 1 SOCE-associated regulatory factor of calcium homoeostasis RskA PF10099.9 CDI75318.1 - 0.00045 20.6 31.8 0.06 13.6 0.2 3.1 1 1 1 2 2 2 1 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI75318.1 - 0.00091 20.1 1.2 0.00091 20.1 1.2 4.5 4 1 0 4 4 3 2 Domain of unknown function (DUF4834) DUF2828 PF11443.8 CDI75318.1 - 0.0011 17.1 1.7 0.0011 17.1 1.7 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF2828) Peptidase_S49_N PF08496.10 CDI75318.1 - 0.0069 16.5 11.0 0.18 11.9 1.1 3.1 3 0 0 3 3 3 2 Peptidase family S49 N-terminal PAS PF00989.25 CDI75318.1 - 0.01 15.8 4.5 0.052 13.6 0.2 2.2 2 0 0 2 2 2 0 PAS fold MLANA PF14991.6 CDI75318.1 - 0.1 12.9 0.0 0.1 12.9 0.0 3.2 3 0 0 3 3 3 0 Protein melan-A Dpy19 PF10034.9 CDI75318.1 - 0.36 9.0 7.1 1.6 6.8 0.7 2.2 2 0 0 2 2 2 0 Q-cell neuroblast polarisation WBP-1 PF11669.8 CDI75318.1 - 0.55 10.9 12.6 0.3 11.7 1.2 3.1 3 0 0 3 3 3 0 WW domain-binding protein 1 Orf78 PF06024.12 CDI75318.1 - 1.1 9.6 21.4 7.2 7.0 0.2 4.6 4 1 0 4 4 3 0 Orf78 (ac78) Het-C PF07217.11 CDI75318.1 - 1.2 7.6 7.7 4.3 5.8 2.4 2.3 2 0 0 2 2 2 0 Heterokaryon incompatibility protein Het-C ANAPC_CDC26 PF10471.9 CDI75318.1 - 1.3 10.0 56.5 0.11 13.4 12.4 4.5 4 0 0 4 4 4 0 Anaphase-promoting complex APC subunit CDC26 AnfO_nitrog PF09582.10 CDI75318.1 - 1.4 8.2 9.3 0.26 10.6 1.2 2.2 2 0 0 2 2 2 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) DUF4770 PF15994.5 CDI75318.1 - 2.9 8.1 27.1 0.28 11.4 2.1 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4770) Anoctamin PF04547.12 CDI75318.1 - 5.2 5.8 6.9 23 3.6 4.5 2.1 2 0 0 2 2 2 0 Calcium-activated chloride channel FAM176 PF14851.6 CDI75318.1 - 5.9 6.5 16.1 6.1 6.5 0.1 3.6 4 0 0 4 4 4 0 FAM176 family DUF2227 PF09988.9 CDI75318.1 - 8 6.3 8.2 1.6 8.6 0.5 2.4 2 0 0 2 2 2 0 Uncharacterized metal-binding protein (DUF2227) SUIM_assoc PF16619.5 CDI75320.1 - 0.001 19.1 0.3 0.001 19.1 0.3 13.0 7 3 3 10 10 10 2 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI75320.1 - 0.0013 19.1 20.8 0.0013 19.1 20.8 9.1 1 1 4 6 6 6 4 Anti-sigma-K factor rskA IQ PF00612.27 CDI75320.1 - 0.0068 16.1 1.7 0.0068 16.1 1.7 3.5 2 0 0 2 2 2 1 IQ calmodulin-binding motif TFIIA PF03153.13 CDI75320.1 - 0.0077 16.3 32.2 0.0077 16.3 32.2 5.8 2 1 2 4 4 4 1 Transcription factor IIA, alpha/beta subunit UPF0258 PF06789.12 CDI75320.1 - 0.019 15.1 0.6 0.019 15.1 0.6 3.8 5 0 0 5 5 5 0 Uncharacterised protein family (UPF0258) LcrG PF07216.12 CDI75321.1 - 0.78 9.7 14.6 0.44 10.5 0.9 3.4 2 0 0 2 2 2 0 LcrG protein SUIM_assoc PF16619.5 CDI75322.1 - 7.5e-05 22.7 0.2 7.5e-05 22.7 0.2 5.1 1 1 1 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Paf1 PF03985.13 CDI75322.1 - 0.32 10.0 25.0 0.4 9.6 25.0 1.2 1 0 0 1 1 1 0 Paf1 SID-1_RNA_chan PF13965.6 CDI75322.1 - 0.92 7.8 4.0 0.85 8.0 4.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Endostatin PF06482.11 CDI75322.1 - 1.3 8.4 20.2 1.9 7.9 20.2 1.4 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF1387 PF07139.11 CDI75322.1 - 2.6 7.7 23.4 3.7 7.2 23.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) GAGA_bind PF06217.12 CDI75322.1 - 3.6 7.8 25.6 5.5 7.2 25.6 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Band_3_cyto PF07565.13 CDI75322.1 - 8.3 6.1 20.3 12 5.6 20.3 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PAP1 PF08601.10 CDI75324.1 - 2.3 7.9 13.8 2.7 7.6 13.8 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 RskA PF10099.9 CDI75325.1 - 1.4e-05 25.5 3.7 1.4e-05 25.5 3.7 3.8 2 2 1 3 3 3 2 Anti-sigma-K factor rskA LMBR1 PF04791.16 CDI75327.1 - 6.2 5.6 10.0 7.1 5.4 10.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Spt20 PF12090.8 CDI75328.1 - 0.0052 16.4 21.4 0.0052 16.4 21.4 5.5 3 1 2 5 5 5 1 Spt20 family Coilin_N PF15862.5 CDI75328.1 - 0.0099 15.7 5.6 0.0099 15.7 5.6 5.6 2 1 3 5 5 5 1 Coilin N-terminus DEAD PF00270.29 CDI75329.1 - 2.5e-28 99.0 0.0 3e-14 53.2 0.0 2.2 1 1 1 2 2 2 2 DEAD/DEAH box helicase Glyco_transf_90 PF05686.12 CDI75331.1 - 5.4e-68 229.7 0.0 7.5e-68 229.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Thioredoxin PF00085.20 CDI75331.1 - 7.8e-40 135.0 0.0 9.6e-21 73.7 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_2 PF13098.6 CDI75331.1 - 2.7e-09 37.4 0.1 0.0017 18.8 0.0 3.3 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDI75331.1 - 1.2e-07 31.7 0.0 0.013 15.7 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 CDI75331.1 - 3.5e-07 29.9 0.1 0.0012 18.3 0.0 3.2 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.6 CDI75331.1 - 0.001 19.0 0.0 0.09 12.7 0.0 2.7 3 0 0 3 3 3 1 Thioredoxin-like domain Glyco_trans_1_2 PF13524.6 CDI75331.1 - 0.0014 19.0 1.3 0.0018 18.7 0.0 1.8 2 0 0 2 2 1 1 Glycosyl transferases group 1 ERp29_N PF07912.13 CDI75331.1 - 0.0038 17.4 0.0 0.048 13.8 0.0 2.3 2 0 0 2 2 2 1 ERp29, N-terminal domain Glutaredoxin PF00462.24 CDI75331.1 - 0.036 14.3 0.1 5.2 7.4 0.0 2.8 2 0 0 2 2 2 0 Glutaredoxin Thioredoxin_9 PF14595.6 CDI75331.1 - 0.043 13.6 0.1 3.5 7.4 0.0 3.0 3 0 0 3 3 3 0 Thioredoxin Thioredoxin_8 PF13905.6 CDI75331.1 - 0.1 12.9 0.1 36 4.8 0.0 3.2 3 1 1 4 4 4 0 Thioredoxin-like EF-hand_1 PF00036.32 CDI75333.1 - 2.8e-27 92.2 5.1 2e-07 30.1 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 CDI75333.1 - 1.1e-24 84.8 3.4 5.6e-07 28.8 0.3 4.8 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 CDI75333.1 - 1.3e-23 83.2 3.1 2.8e-12 46.9 0.5 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI75333.1 - 1.5e-20 71.3 4.4 0.00095 18.9 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 CDI75333.1 - 1.4e-12 47.2 8.4 3.7e-05 23.5 1.4 4.6 4 1 1 5 5 5 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDI75333.1 - 1.4e-09 38.2 0.0 0.00029 21.1 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 CDI75333.1 - 4.2e-05 23.4 2.3 0.15 12.0 0.4 3.2 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 CDI75333.1 - 0.00022 21.3 4.7 0.0087 16.2 0.1 3.8 2 1 2 4 4 4 3 Dockerin type I domain EF-hand_9 PF14658.6 CDI75333.1 - 0.00066 20.0 0.0 0.049 14.0 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain NOD2_WH PF17779.1 CDI75333.1 - 0.031 14.6 0.1 1.7 9.1 0.0 2.7 3 0 0 3 3 3 0 NOD2 winged helix domain Caleosin PF05042.13 CDI75333.1 - 0.072 13.0 1.6 6 6.8 0.0 3.2 2 1 2 4 4 4 0 Caleosin related protein BDV_P40 PF06407.11 CDI75333.1 - 0.08 12.0 0.0 0.22 10.6 0.0 1.7 2 0 0 2 2 2 0 Borna disease virus P40 protein PUB PF09409.10 CDI75334.1 - 0.01 15.8 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 PUB domain Asp PF00026.23 CDI75334.1 - 0.16 11.3 0.0 0.22 10.9 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic aspartyl protease Mito_carr PF00153.27 CDI75335.1 - 4.2e-39 132.4 0.7 1.3e-16 60.3 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein CcmF_C PF16327.5 CDI75337.1 - 2.8 7.1 4.5 16 4.6 4.5 2.3 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal SPX PF03105.19 CDI75338.1 - 0.0006 19.8 16.2 0.0006 19.8 16.2 2.5 1 1 1 2 2 2 1 SPX domain DUF4667 PF15700.5 CDI75338.1 - 0.00068 19.8 5.9 0.00068 19.8 5.9 3.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4667) DUF4366 PF14283.6 CDI75338.1 - 0.014 15.5 0.2 0.014 15.5 0.2 3.3 5 0 0 5 5 5 0 Domain of unknown function (DUF4366) DUF5446 PF17522.2 CDI75338.1 - 0.27 11.4 2.0 17 5.7 0.2 3.0 2 0 0 2 2 2 0 Family of unknown function (DUF5446) ParA PF10609.9 CDI75339.1 - 1.7e-26 93.2 0.1 2.9e-26 92.4 0.1 1.4 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CDI75339.1 - 9.2e-09 35.4 0.1 2e-08 34.3 0.0 1.6 2 0 0 2 2 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 CDI75339.1 - 1.9e-07 30.6 1.6 2.2e-06 27.1 0.0 2.3 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_31 PF13614.6 CDI75339.1 - 2.2e-05 24.4 0.0 3.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Spt20 PF12090.8 CDI75339.1 - 0.00016 21.3 8.3 0.00019 21.1 8.3 1.1 1 0 0 1 1 1 1 Spt20 family MipZ PF09140.11 CDI75339.1 - 0.00029 20.2 0.1 0.0011 18.3 0.0 1.8 2 0 0 2 2 2 1 ATPase MipZ CBP_BcsQ PF06564.12 CDI75339.1 - 0.00031 20.3 0.9 0.0026 17.3 0.0 2.1 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ TFIIA PF03153.13 CDI75339.1 - 0.00033 20.8 8.1 0.0004 20.5 8.1 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI75339.1 - 0.0016 17.5 6.6 0.0019 17.2 6.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) NB-ARC PF00931.22 CDI75339.1 - 0.0017 17.6 0.1 0.0017 17.6 0.1 1.5 2 0 0 2 2 2 1 NB-ARC domain RsgA_GTPase PF03193.16 CDI75339.1 - 0.0023 17.9 0.5 0.0048 16.8 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase Herpes_DNAp_acc PF04929.12 CDI75339.1 - 0.0025 16.8 3.6 0.0038 16.3 3.6 1.2 1 0 0 1 1 1 1 Herpes DNA replication accessory factor RskA PF10099.9 CDI75339.1 - 0.0026 18.1 22.2 0.0063 16.8 7.1 2.2 2 0 0 2 2 2 1 Anti-sigma-K factor rskA AAA_18 PF13238.6 CDI75339.1 - 0.0028 18.2 0.5 0.0063 17.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CDI75339.1 - 0.0029 17.2 1.5 0.0033 17.0 0.2 1.8 2 1 0 2 2 2 1 AAA domain LapA_dom PF06305.11 CDI75339.1 - 0.0035 17.1 1.2 0.0061 16.3 1.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain APS_kinase PF01583.20 CDI75339.1 - 0.0095 15.8 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase T2SSE PF00437.20 CDI75339.1 - 0.0096 15.0 0.1 0.017 14.2 0.0 1.5 2 0 0 2 2 2 1 Type II/IV secretion system protein MeaB PF03308.16 CDI75339.1 - 0.018 14.0 1.4 0.057 12.4 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Phage_holin_2_4 PF16082.5 CDI75339.1 - 0.026 14.3 0.8 0.026 14.3 0.8 2.1 2 1 0 2 2 1 0 Bacteriophage holin family, superfamily II-like DUF2681 PF10883.8 CDI75339.1 - 0.027 14.9 12.1 0.027 14.9 12.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF908 PF06012.12 CDI75339.1 - 0.028 13.9 0.5 0.041 13.3 0.5 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Rad17 PF03215.15 CDI75339.1 - 0.035 14.0 0.0 0.067 13.1 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_16 PF13191.6 CDI75339.1 - 0.035 14.5 0.2 0.035 14.5 0.2 2.2 1 1 1 2 2 1 0 AAA ATPase domain RAB3GAP2_N PF14655.6 CDI75339.1 - 0.037 13.3 3.1 0.21 10.8 3.6 1.7 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus NTPase_1 PF03266.15 CDI75339.1 - 0.037 13.9 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 NTPase EphA2_TM PF14575.6 CDI75339.1 - 0.039 14.8 0.1 0.074 13.9 0.1 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Fer4_NifH PF00142.18 CDI75339.1 - 0.062 12.7 0.1 0.13 11.7 0.0 1.5 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family KTI12 PF08433.10 CDI75339.1 - 0.066 12.7 1.5 0.18 11.2 0.0 2.0 2 0 0 2 2 2 0 Chromatin associated protein KTI12 FxsA PF04186.13 CDI75339.1 - 0.15 12.2 0.2 0.15 12.2 0.2 1.7 2 0 0 2 2 1 0 FxsA cytoplasmic membrane protein T2SSC PF11356.8 CDI75339.1 - 0.47 10.3 9.3 0.39 10.6 3.7 2.2 2 0 0 2 2 2 0 Type II secretion system protein C Ndc1_Nup PF09531.10 CDI75339.1 - 0.48 9.1 2.3 0.54 8.9 2.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AAA_23 PF13476.6 CDI75339.1 - 0.64 10.5 7.8 3.7 8.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CDI75339.1 - 0.68 9.7 5.1 1.2 8.9 0.1 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF4834 PF16118.5 CDI75339.1 - 0.79 10.7 3.4 1.4 9.9 3.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF533 PF04391.12 CDI75339.1 - 0.8 9.3 17.7 0.073 12.6 8.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF533) Roughex PF06020.11 CDI75339.1 - 0.8 8.7 5.1 0.95 8.5 5.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein AAA_24 PF13479.6 CDI75339.1 - 1 9.1 0.1 1 9.1 0.1 1.9 2 0 0 2 2 2 0 AAA domain DUF5421 PF17458.2 CDI75339.1 - 1.2 8.4 5.7 1.7 8.0 5.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5421) PAP_PilO PF06864.12 CDI75339.1 - 1.3 7.7 12.1 0.22 10.3 8.7 1.4 1 1 0 1 1 1 0 Pilin accessory protein (PilO) DUF3381 PF11861.8 CDI75339.1 - 1.7 8.5 7.4 3 7.6 7.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3381) AAA_22 PF13401.6 CDI75339.1 - 2.1 8.6 4.7 1 9.6 0.4 2.3 1 1 2 3 3 3 0 AAA domain FHIPEP PF00771.20 CDI75339.1 - 2.4 6.5 5.6 1.3 7.4 3.8 1.4 1 1 0 1 1 1 0 FHIPEP family DUF3138 PF11336.8 CDI75339.1 - 5 5.6 15.5 7.1 5.1 15.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Shadoo PF14999.6 CDI75339.1 - 9.2 6.4 22.7 0.53 10.4 0.2 2.6 2 1 0 2 2 2 0 Shadow of prion protein, neuroprotective DNA_pol_alpha_N PF12254.8 CDI75340.1 - 3.8e-12 46.1 6.3 1.5e-11 44.2 6.3 2.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal SUIM_assoc PF16619.5 CDI75340.1 - 0.01 15.9 24.4 0.37 10.9 4.8 4.2 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 K_channel_TID PF07941.11 CDI75340.1 - 0.022 15.2 14.0 0.022 15.2 14.0 8.2 7 2 2 9 9 9 0 Potassium channel Kv1.4 tandem inactivation domain Med24_N PF11277.8 CDI75340.1 - 0.53 8.3 4.9 0.27 9.2 2.9 1.5 1 1 0 1 1 1 0 Mediator complex subunit 24 N-terminal Sulf_transp PF04143.14 CDI75341.1 - 0.24 10.9 3.8 0.32 10.5 3.8 1.2 1 0 0 1 1 1 0 Sulphur transport STE3 PF02076.15 CDI75341.1 - 0.42 9.8 1.1 0.63 9.2 1.1 1.2 1 0 0 1 1 1 0 Pheromone A receptor CcmF_C PF16327.5 CDI75341.1 - 0.59 9.4 3.6 0.79 8.9 3.6 1.3 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal TFIIA PF03153.13 CDI75341.1 - 0.98 9.3 47.5 1.4 8.8 47.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDC27 PF09507.10 CDI75341.1 - 1.2 8.4 53.8 1.7 7.9 53.8 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Abhydrolase_9_N PF15420.6 CDI75341.1 - 8.7 6.3 11.4 29 4.6 11.4 1.8 1 1 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus DUF3295 PF11702.8 CDI75342.1 - 0.53 9.6 4.3 0.33 10.2 2.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3295) TFIIA PF03153.13 CDI75342.1 - 1 9.3 19.1 1.2 9.0 19.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM176 PF14851.6 CDI75343.1 - 0.0011 18.7 5.2 0.0015 18.2 5.2 1.3 1 0 0 1 1 1 1 FAM176 family CLN3 PF02487.17 CDI75343.1 - 0.025 13.7 15.7 0.026 13.6 15.7 1.0 1 0 0 1 1 1 0 CLN3 protein V_ATPase_I PF01496.19 CDI75343.1 - 0.041 11.8 26.2 0.047 11.6 26.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ureide_permease PF07168.11 CDI75343.1 - 0.057 12.2 5.0 0.071 11.8 5.0 1.1 1 0 0 1 1 1 0 Ureide permease CobT PF06213.12 CDI75343.1 - 0.12 11.8 28.2 0.15 11.5 28.2 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF1180 PF06679.12 CDI75343.1 - 0.31 11.4 7.4 0.35 11.2 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Rtf2 PF04641.12 CDI75343.1 - 0.33 10.3 16.2 0.38 10.1 16.2 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger SID-1_RNA_chan PF13965.6 CDI75343.1 - 0.34 9.3 9.9 0.38 9.1 9.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TRAP_alpha PF03896.16 CDI75343.1 - 0.4 9.8 8.6 0.48 9.6 8.6 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4746 PF15928.5 CDI75343.1 - 0.42 10.0 14.8 0.49 9.8 14.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CBP_BcsG PF11658.8 CDI75343.1 - 0.47 8.8 18.3 0.53 8.6 18.3 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Folate_carrier PF01770.18 CDI75343.1 - 0.52 9.0 13.8 0.61 8.7 13.8 1.1 1 0 0 1 1 1 0 Reduced folate carrier NPR3 PF03666.13 CDI75343.1 - 1.1 7.9 22.4 1.2 7.9 22.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 YABBY PF04690.13 CDI75343.1 - 1.4 9.4 18.6 1.7 9.2 18.6 1.2 1 0 0 1 1 1 0 YABBY protein CSG2 PF16965.5 CDI75343.1 - 1.5 7.7 11.5 1.7 7.5 11.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DDHD PF02862.17 CDI75343.1 - 1.8 8.7 18.8 2.8 8.1 18.8 1.3 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 CDI75343.1 - 2.3 8.0 25.2 2.4 7.9 25.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PIP5K PF01504.18 CDI75343.1 - 2.3 7.4 18.7 3.3 6.9 18.7 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase AAA_11 PF13086.6 CDI75343.1 - 2.4 7.8 22.7 2.8 7.7 22.7 1.1 1 0 0 1 1 1 0 AAA domain DUF2828 PF11443.8 CDI75343.1 - 2.6 6.0 24.9 3.1 5.8 24.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Gti1_Pac2 PF09729.9 CDI75343.1 - 2.9 8.0 21.3 3.2 7.8 21.3 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4228 PF14009.6 CDI75343.1 - 2.9 8.3 13.9 3.2 8.1 13.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) PAT1 PF09770.9 CDI75343.1 - 3.1 5.9 41.9 3.1 6.0 41.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FAM76 PF16046.5 CDI75343.1 - 3.3 7.0 28.2 4.6 6.5 28.2 1.3 1 0 0 1 1 1 0 FAM76 protein Velvet PF11754.8 CDI75343.1 - 3.6 7.4 24.3 4 7.3 24.3 1.1 1 0 0 1 1 1 0 Velvet factor Neur_chan_memb PF02932.16 CDI75343.1 - 3.7 7.5 22.3 3.9 7.5 22.3 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region O-antigen_lig PF13425.6 CDI75343.1 - 4.1 6.1 11.2 4.3 6.0 11.2 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein UPF0565 PF10561.9 CDI75343.1 - 4.3 6.5 19.4 4.8 6.3 19.4 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 BORG_CEP PF14957.6 CDI75343.1 - 4.3 8.5 19.2 4.6 8.4 19.2 1.1 1 0 0 1 1 1 0 Cdc42 effector DUF2232 PF09991.9 CDI75343.1 - 4.6 6.3 5.0 5.1 6.2 5.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Serinc PF03348.15 CDI75343.1 - 4.7 6.0 12.3 5.2 5.9 12.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Tim54 PF11711.8 CDI75343.1 - 5.1 5.8 20.2 6 5.5 20.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Mem_trans PF03547.18 CDI75343.1 - 5.2 5.4 9.6 5.5 5.3 9.6 1.0 1 0 0 1 1 1 0 Membrane transport protein Baculo_PP31 PF05311.11 CDI75343.1 - 5.5 6.4 18.9 7.9 5.9 18.9 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF2126 PF09899.9 CDI75343.1 - 5.8 4.9 16.1 6.2 4.8 16.1 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Presenilin PF01080.17 CDI75343.1 - 6 5.5 32.0 6.8 5.3 32.0 1.0 1 0 0 1 1 1 0 Presenilin Membralin PF09746.9 CDI75343.1 - 7.3 5.5 17.4 7.6 5.5 17.4 1.0 1 0 0 1 1 1 0 Tumour-associated protein Pex14_N PF04695.13 CDI75343.1 - 7.6 7.2 36.4 12 6.5 36.4 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Scs3p PF10261.9 CDI75343.1 - 7.9 5.9 10.0 10 5.5 10.0 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM SLC12 PF03522.15 CDI75343.1 - 8.2 5.3 27.1 8.8 5.2 27.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 TFIIA PF03153.13 CDI75344.1 - 0.0013 18.8 25.6 0.0013 18.8 25.6 2.3 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Secretin_N_2 PF07655.13 CDI75345.1 - 0.018 15.6 20.4 0.022 15.3 20.4 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain DUF4614 PF15391.6 CDI75345.1 - 0.17 11.9 18.0 0.2 11.7 18.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) DUF4834 PF16118.5 CDI75345.1 - 1.3 10.0 4.4 1.7 9.6 4.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF1635 PF07795.11 CDI75345.1 - 1.5 8.7 9.7 1.7 8.4 9.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) CCDC106 PF15794.5 CDI75345.1 - 2.4 7.8 12.4 2.8 7.6 12.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Neur_chan_memb PF02932.16 CDI75345.1 - 2.5 8.1 6.0 2.8 7.9 6.0 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RIFIN PF02009.16 CDI75345.1 - 2.5 7.9 10.4 2.8 7.8 10.4 1.0 1 0 0 1 1 1 0 Rifin MMU163 PF17119.5 CDI75345.1 - 2.7 7.1 5.6 2.8 7.0 5.6 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Apc15p PF05841.11 CDI75345.1 - 3.1 8.6 10.4 3.7 8.4 10.4 1.2 1 0 0 1 1 1 0 Apc15p protein DUF966 PF06136.13 CDI75345.1 - 3.7 7.2 16.1 4 7.1 16.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) BAF1_ABF1 PF04684.13 CDI75345.1 - 3.8 6.5 14.4 4 6.4 14.4 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor NPR3 PF03666.13 CDI75345.1 - 4.2 6.0 10.7 4.4 6.0 10.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ANAPC1 PF12859.7 CDI75345.1 - 4.4 7.9 10.1 5 7.7 10.1 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 Presenilin PF01080.17 CDI75345.1 - 5.8 5.6 11.1 6.5 5.4 11.1 1.0 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 CDI75345.1 - 6.2 5.6 16.7 6.3 5.5 16.7 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Med3 PF11593.8 CDI75346.1 - 0.0014 17.9 13.1 0.0019 17.5 13.1 1.2 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal SUIM_assoc PF16619.5 CDI75346.1 - 0.012 15.6 11.3 0.012 15.6 11.3 2.8 2 1 1 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI75346.1 - 2.9 7.8 18.3 3.6 7.5 18.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hid1 PF12722.7 CDI75346.1 - 6.5 4.7 17.6 7 4.6 17.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Raftlin PF15250.6 CDI75346.1 - 7.3 5.2 14.6 9.1 4.9 14.6 1.0 1 0 0 1 1 1 0 Raftlin CDC45 PF02724.14 CDI75346.1 - 9.4 4.4 18.0 12 4.0 18.0 1.0 1 0 0 1 1 1 0 CDC45-like protein SOBP PF15279.6 CDI75346.1 - 9.5 6.7 23.2 13 6.3 23.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein UBA2_C PF16195.5 CDI75347.1 - 0.0009 19.9 2.6 0.0009 19.9 2.6 3.7 5 0 0 5 5 5 1 SUMO-activating enzyme subunit 2 C-terminus DUF1645 PF07816.11 CDI75347.1 - 0.0011 19.6 9.4 0.1 13.2 0.2 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF1645) Secretin_N_2 PF07655.13 CDI75347.1 - 3.2 8.4 16.8 3.9 8.1 5.4 2.7 2 0 0 2 2 2 0 Secretin N-terminal domain SR-25 PF10500.9 CDI75347.1 - 4.1 7.0 28.1 2.7 7.5 6.9 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4637 PF15470.6 CDI75348.1 - 0.00013 21.7 6.7 0.00034 20.4 6.8 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4637) Sin_N PF04801.13 CDI75348.1 - 0.00062 19.1 25.2 0.00084 18.7 25.2 1.1 1 0 0 1 1 1 1 Sin-like protein conserved region V_ATPase_I PF01496.19 CDI75348.1 - 0.00085 17.4 5.4 0.00085 17.4 5.4 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Es2 PF09751.9 CDI75348.1 - 0.0022 17.8 8.6 0.0027 17.5 8.6 1.1 1 0 0 1 1 1 1 Nuclear protein Es2 Plasmodium_Vir PF05795.11 CDI75348.1 - 0.0051 16.3 5.2 0.0076 15.7 3.4 1.8 2 0 0 2 2 2 1 Plasmodium vivax Vir protein SUIM_assoc PF16619.5 CDI75348.1 - 0.0074 16.3 11.3 0.0074 16.3 11.3 5.0 2 1 0 2 2 1 1 Unstructured region C-term to UIM in Ataxin3 DUF4746 PF15928.5 CDI75348.1 - 0.0078 15.7 7.5 0.01 15.3 7.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) EPL1 PF10513.9 CDI75348.1 - 0.017 15.5 9.9 0.026 14.9 9.9 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like TRAP_alpha PF03896.16 CDI75348.1 - 0.029 13.6 5.4 0.042 13.1 5.4 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CAC1F_C PF16885.5 CDI75348.1 - 0.033 13.8 8.6 0.046 13.4 8.6 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term CDC45 PF02724.14 CDI75348.1 - 0.045 12.1 7.7 0.052 11.8 7.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Otopetrin PF03189.13 CDI75348.1 - 0.088 11.6 1.0 0.074 11.9 1.0 1.2 1 0 0 1 1 1 0 Otopetrin ALMT PF11744.8 CDI75348.1 - 0.11 11.3 13.4 0.15 10.8 13.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter AUX_IAA PF02309.16 CDI75348.1 - 0.55 10.1 10.7 0.97 9.2 10.7 1.3 1 0 0 1 1 1 0 AUX/IAA family Hid1 PF12722.7 CDI75348.1 - 0.55 8.3 12.1 0.66 8.0 12.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Borrelia_P83 PF05262.11 CDI75348.1 - 0.56 8.6 14.5 0.53 8.7 14.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein MMR1 PF08505.10 CDI75348.1 - 0.88 9.8 15.4 1.5 9.0 15.4 1.5 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Band_3_cyto PF07565.13 CDI75348.1 - 1.1 9.1 13.3 1.5 8.5 13.3 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PAT1 PF09770.9 CDI75348.1 - 1.1 7.5 27.6 1.3 7.2 27.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ndc1_Nup PF09531.10 CDI75348.1 - 1.1 7.8 12.0 1.2 7.7 12.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Neur_chan_memb PF02932.16 CDI75348.1 - 1.2 9.1 12.2 2 8.4 12.2 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Cellulose_synt PF03552.14 CDI75348.1 - 1.7 7.0 4.2 2.1 6.7 4.2 1.1 1 0 0 1 1 1 0 Cellulose synthase Pex14_N PF04695.13 CDI75348.1 - 1.8 9.2 32.5 0.58 10.8 28.6 2.1 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 CDI75348.1 - 2.3 6.9 19.9 3.9 6.1 19.9 1.3 1 0 0 1 1 1 0 Presenilin DUF2052 PF09747.9 CDI75348.1 - 2.4 8.2 20.1 4.4 7.4 20.1 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CPSF100_C PF13299.6 CDI75348.1 - 2.8 8.1 12.9 7 6.8 12.9 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal OATP PF03137.20 CDI75348.1 - 3 6.0 6.4 4.5 5.4 6.4 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SpoIIP PF07454.11 CDI75348.1 - 3.2 7.1 17.7 4.7 6.6 17.7 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Adeno_PIX PF03955.14 CDI75348.1 - 4 7.7 12.9 5.6 7.2 1.9 2.2 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) Afi1 PF07792.12 CDI75348.1 - 4.4 7.8 18.1 6.8 7.2 18.1 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Rtf2 PF04641.12 CDI75348.1 - 6 6.1 18.8 10 5.4 18.8 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger FAM176 PF14851.6 CDI75348.1 - 6.7 6.4 9.5 17 5.0 9.5 1.7 1 0 0 1 1 1 0 FAM176 family SLC12 PF03522.15 CDI75348.1 - 7.9 5.4 19.4 12 4.8 19.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF4638 PF15472.6 CDI75348.1 - 9 5.9 16.1 14 5.3 16.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) CLN3 PF02487.17 CDI75350.1 - 0.0053 15.9 1.8 0.0053 15.9 1.8 2.5 2 1 1 3 3 3 1 CLN3 protein SUIM_assoc PF16619.5 CDI75350.1 - 0.015 15.4 6.9 0.015 15.4 6.9 4.3 5 0 0 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 MitMem_reg PF13012.6 CDI75350.1 - 0.019 15.4 0.0 0.019 15.4 0.0 2.7 3 1 0 3 3 3 0 Maintenance of mitochondrial structure and function Dala_Dala_lig_N PF01820.21 CDI75350.1 - 0.066 13.7 0.5 1.3 9.5 0.3 2.7 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus TMEM164 PF14808.6 CDI75350.1 - 0.28 10.5 0.8 0.51 9.6 0.8 1.3 1 0 0 1 1 1 0 TMEM164 family DUF2722 PF10846.8 CDI75351.1 - 0.0018 17.3 3.2 0.0018 17.3 3.2 5.3 4 2 0 4 4 4 2 Protein of unknown function (DUF2722) Glyco_hydro_35 PF01301.19 CDI75351.1 - 2.2 7.8 5.3 0.26 10.9 0.2 1.9 2 0 0 2 2 2 0 Glycosyl hydrolases family 35 DUF3138 PF11336.8 CDI75352.1 - 0.08 11.5 4.0 0.1 11.2 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Glyco_hydro_9 PF00759.19 CDI75352.1 - 0.45 9.9 3.9 0.53 9.6 3.9 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 Spt20 PF12090.8 CDI75352.1 - 0.49 10.0 9.0 0.57 9.8 9.0 1.1 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI75352.1 - 1.1 9.1 7.8 1.3 8.9 7.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Bclt PF15318.6 CDI75352.1 - 6 6.7 9.3 29 4.4 5.5 2.1 1 1 1 2 2 2 0 Putative Bcl-2 like protein of testis SR-25 PF10500.9 CDI75354.1 - 0.011 15.4 14.9 0.011 15.3 14.9 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 CDI75356.1 - 0.00085 18.2 8.4 0.00085 18.2 8.4 3.1 2 1 0 2 2 2 1 Presenilin Plasmodium_Vir PF05795.11 CDI75356.1 - 0.0028 17.1 2.9 0.0028 17.1 2.9 2.9 2 1 0 2 2 2 1 Plasmodium vivax Vir protein TFIIA PF03153.13 CDI75356.1 - 0.0029 17.7 25.3 0.0029 17.7 25.3 3.3 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.10 CDI75356.1 - 0.003 17.0 8.8 0.003 17.0 8.8 2.3 2 0 0 2 2 2 1 BUD22 BRF1 PF07741.13 CDI75356.1 - 0.0073 16.6 2.2 0.0073 16.6 2.2 4.0 3 2 0 3 3 3 1 Brf1-like TBP-binding domain SpoIIP PF07454.11 CDI75356.1 - 0.011 15.2 2.0 0.011 15.2 2.0 3.8 3 1 1 4 4 4 0 Stage II sporulation protein P (SpoIIP) BAF1_ABF1 PF04684.13 CDI75356.1 - 0.36 9.8 50.1 0.72 8.8 26.3 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor RPA43_OB PF17875.1 CDI75356.1 - 0.92 10.1 30.3 0.11 13.1 1.0 3.8 4 0 0 4 4 4 0 RPA43 OB domain in RNA Pol I QRPTase_N PF02749.16 CDI75356.1 - 0.96 9.5 3.4 0.29 11.2 0.5 1.6 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain Myosin_head PF00063.21 CDI75357.1 - 2.9e-15 55.6 0.2 2.9e-15 55.6 0.2 2.5 1 1 1 2 2 1 1 Myosin head (motor domain) AAA_16 PF13191.6 CDI75357.1 - 0.0024 18.3 0.4 0.0024 18.3 0.4 2.2 1 1 1 2 2 1 1 AAA ATPase domain TsaE PF02367.17 CDI75357.1 - 0.0044 17.0 0.5 0.0079 16.2 0.1 1.6 1 1 1 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Presenilin PF01080.17 CDI75357.1 - 0.019 13.7 33.0 0.02 13.7 33.0 1.1 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 CDI75357.1 - 0.033 12.7 21.5 0.04 12.5 21.5 1.0 1 0 0 1 1 1 0 Macoilin family AAA_18 PF13238.6 CDI75357.1 - 0.14 12.8 0.1 0.14 12.8 0.1 2.8 2 1 0 2 2 1 0 AAA domain Kinesin PF00225.23 CDI75357.1 - 0.14 11.0 18.7 0.22 10.4 18.7 1.3 1 0 0 1 1 1 0 Kinesin motor domain AAA_24 PF13479.6 CDI75357.1 - 0.18 11.5 0.0 0.18 11.5 0.0 3.0 2 1 1 3 3 1 0 AAA domain Sin_N PF04801.13 CDI75357.1 - 0.22 10.7 40.5 0.23 10.6 40.5 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region Dicty_REP PF05086.12 CDI75357.1 - 0.26 9.2 18.5 0.26 9.2 18.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SAPS PF04499.15 CDI75357.1 - 0.3 9.8 20.0 0.35 9.6 20.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Membralin PF09746.9 CDI75357.1 - 0.35 9.8 16.2 0.39 9.7 16.2 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF4045 PF13254.6 CDI75357.1 - 0.37 10.4 22.9 0.4 10.3 22.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF5427 PF10310.9 CDI75357.1 - 0.41 9.6 28.7 0.46 9.4 28.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) CAC1F_C PF16885.5 CDI75357.1 - 0.43 10.2 18.5 0.46 10.1 18.5 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term NPR3 PF03666.13 CDI75357.1 - 0.58 8.9 28.0 0.65 8.7 28.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3295 PF11702.8 CDI75357.1 - 0.74 9.1 27.3 0.87 8.9 27.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) PNISR PF15996.5 CDI75357.1 - 1.1 9.5 37.7 1.2 9.4 37.7 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF572 PF04502.13 CDI75357.1 - 1.6 8.3 26.2 2 8.0 26.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF2052 PF09747.9 CDI75357.1 - 2.1 8.4 28.8 2.5 8.2 28.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Ndc1_Nup PF09531.10 CDI75357.1 - 2.2 6.8 26.7 2.5 6.7 26.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 CDI75357.1 - 2.4 6.3 49.8 2.8 6.1 49.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4820 PF16091.5 CDI75357.1 - 3.5 6.9 24.4 5.1 6.4 24.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Endostatin PF06482.11 CDI75357.1 - 3.6 7.0 28.3 5 6.5 28.3 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin RsgA_GTPase PF03193.16 CDI75357.1 - 3.6 7.4 14.5 3.9 7.4 12.7 1.8 1 1 1 2 2 2 0 RsgA GTPase Nop25 PF09805.9 CDI75357.1 - 3.7 8.0 36.1 5.2 7.5 36.1 1.4 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Neur_chan_memb PF02932.16 CDI75357.1 - 3.8 7.5 28.1 4.4 7.3 28.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CCSAP PF15748.5 CDI75357.1 - 4.5 7.4 36.4 5.1 7.2 36.4 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Caldesmon PF02029.15 CDI75357.1 - 6.3 5.4 33.8 7.3 5.2 33.8 1.1 1 0 0 1 1 1 0 Caldesmon SLC12 PF03522.15 CDI75357.1 - 6.6 5.6 36.6 7.7 5.4 36.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PIG-S PF10510.9 CDI75357.1 - 6.9 5.4 27.0 8.1 5.1 27.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein DUF4569 PF15133.6 CDI75357.1 - 7 6.3 32.3 11 5.7 32.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Hid1 PF12722.7 CDI75357.1 - 7.5 4.5 31.6 8.8 4.3 31.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Peptidase_S64 PF08192.11 CDI75357.1 - 8 4.8 26.5 9.3 4.6 26.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 MDM10 PF12519.8 CDI75357.1 - 9.5 5.0 26.5 9.9 4.9 26.5 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Vitelline_membr PF10542.9 CDI75358.1 - 0.026 14.4 2.2 0.026 14.4 2.2 3.6 3 0 0 3 3 3 0 Vitelline membrane cysteine-rich region RskA PF10099.9 CDI75359.1 - 4.8e-07 30.2 1.8 4.8e-07 30.2 1.8 5.2 1 1 4 5 5 5 1 Anti-sigma-K factor rskA AP2 PF00847.20 CDI75359.1 - 0.04 14.2 3.4 0.04 14.2 3.4 2.7 2 1 0 2 2 2 0 AP2 domain Hamartin PF04388.12 CDI75359.1 - 0.2 10.3 46.4 0.26 9.9 46.4 1.2 1 0 0 1 1 1 0 Hamartin protein Borrelia_P83 PF05262.11 CDI75359.1 - 2.9 6.3 34.9 4.1 5.8 34.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Macoilin PF09726.9 CDI75359.1 - 6.8 5.1 42.4 12 4.3 42.4 1.4 1 0 0 1 1 1 0 Macoilin family RskA PF10099.9 CDI75360.1 - 0.002 18.5 2.2 0.002 18.5 2.2 6.9 1 1 4 5 5 4 1 Anti-sigma-K factor rskA Tmemb_9 PF05434.11 CDI75360.1 - 0.01 15.7 0.6 0.01 15.7 0.6 4.3 3 1 1 4 4 3 0 TMEM9 SARAF PF06682.12 CDI75360.1 - 0.013 15.1 1.2 0.013 15.1 1.2 4.5 3 2 1 4 4 3 0 SOCE-associated regulatory factor of calcium homoeostasis ETRAMP PF09716.10 CDI75360.1 - 0.015 15.3 0.2 0.015 15.3 0.2 6.0 6 1 1 7 7 6 0 Malarial early transcribed membrane protein (ETRAMP) EBP50_C PF09007.11 CDI75360.1 - 0.018 16.0 1.7 0.018 16.0 1.7 5.7 3 2 1 4 4 2 0 EBP50, C-terminal Oxidored_q3 PF00499.20 CDI75360.1 - 0.058 13.1 1.3 0.17 11.6 0.2 2.4 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 COX2_TM PF02790.15 CDI75360.1 - 0.11 12.6 1.1 20 5.4 0.2 2.7 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain DUF2207 PF09972.9 CDI75360.1 - 0.17 10.6 0.3 1.7 7.3 0.2 2.5 1 1 2 3 3 3 0 Predicted membrane protein (DUF2207) 7TM_GPCR_Str PF10326.9 CDI75360.1 - 0.27 10.5 1.6 0.47 9.8 1.6 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Str Ion_trans PF00520.31 CDI75360.1 - 0.95 8.6 2.7 3.9 6.6 2.7 1.9 1 1 0 1 1 1 0 Ion transport protein DUF3522 PF12036.8 CDI75360.1 - 1.7 8.9 7.2 6.1 7.1 0.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3522) DUF3169 PF11368.8 CDI75360.1 - 2 7.9 4.1 13 5.2 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3169) MFS_1_like PF12832.7 CDI75360.1 - 5.1 5.8 6.6 0.23 10.3 1.1 1.5 2 0 0 2 2 2 0 MFS_1 like family RskA PF10099.9 CDI75361.1 - 0.00029 21.2 8.3 0.00047 20.5 8.3 1.4 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Shadoo PF14999.6 CDI75361.1 - 0.045 13.9 3.2 0.14 12.3 3.2 1.8 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective DUF2232 PF09991.9 CDI75361.1 - 5.7 6.0 5.4 7.8 5.6 5.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Spt20 PF12090.8 CDI75362.1 - 9.6e-07 28.7 20.4 3.6e-05 23.5 7.5 5.6 4 2 1 5 5 5 3 Spt20 family DUF2722 PF10846.8 CDI75362.1 - 0.00014 21.0 5.0 0.00014 21.0 5.0 6.1 4 2 1 5 5 5 2 Protein of unknown function (DUF2722) Inositol_P PF00459.25 CDI75362.1 - 0.011 15.2 0.0 0.011 15.2 0.0 4.3 4 0 0 4 4 4 0 Inositol monophosphatase family DUF3824 PF12868.7 CDI75364.1 - 0.021 15.5 9.4 0.021 15.5 9.4 3.7 2 1 1 3 3 3 0 Domain of unknwon function (DUF3824) SR-25 PF10500.9 CDI75364.1 - 0.059 13.0 119.2 0.014 15.0 74.3 3.0 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein RNA_pol_Rpb1_1 PF04997.12 CDI75365.1 - 0.0012 18.3 6.2 0.0066 15.8 6.1 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RskA PF10099.9 CDI75365.1 - 0.0027 18.1 11.1 0.0027 18.1 11.1 2.2 1 1 1 2 2 2 1 Anti-sigma-K factor rskA PI3K_1B_p101 PF10486.9 CDI75365.1 - 0.016 13.0 13.1 0.025 12.4 13.1 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit OAD_gamma PF04277.13 CDI75365.1 - 0.1 13.2 0.2 0.1 13.2 0.2 3.7 2 1 1 3 3 1 0 Oxaloacetate decarboxylase, gamma chain PIP5K PF01504.18 CDI75365.1 - 0.25 10.5 5.5 0.39 9.9 5.5 1.4 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase SR-25 PF10500.9 CDI75365.1 - 0.3 10.7 24.5 0.15 11.7 15.5 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RAB3GAP2_N PF14655.6 CDI75365.1 - 0.32 10.2 11.5 0.48 9.6 11.5 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Med15 PF09606.10 CDI75365.1 - 0.6 8.7 30.2 0.8 8.3 30.2 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CCSAP PF15748.5 CDI75365.1 - 1.4 9.1 21.9 2.2 8.4 21.9 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CNOT1_HEAT PF16418.5 CDI75365.1 - 5.6 7.0 16.3 2.7 8.0 8.2 2.2 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 HEAT repeat SLC12 PF03522.15 CDI75365.1 - 9 5.2 16.3 12 4.8 16.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 SUIM_assoc PF16619.5 CDI75366.1 - 0.11 12.5 21.0 0.39 10.8 10.6 3.2 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Ribosomal_60s PF00428.19 CDI75367.1 - 0.092 13.3 0.4 0.39 11.3 0.0 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Caldesmon PF02029.15 CDI75367.1 - 2.9 6.5 47.8 4.1 6.1 47.8 1.1 1 0 0 1 1 1 0 Caldesmon Cwf_Cwc_15 PF04889.12 CDI75368.1 - 8 6.1 66.6 4.1 7.1 24.2 3.5 2 1 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Draxin PF15550.6 CDI75368.1 - 8.2 6.2 53.0 0.58 10.0 18.3 2.1 2 0 0 2 2 2 0 Draxin Tti2 PF10521.9 CDI75369.1 - 0.002 17.7 0.0 0.0058 16.2 0.0 1.7 2 0 0 2 2 2 1 Tti2 family AAA_11 PF13086.6 CDI75370.1 - 5.9e-56 190.1 5.3 6.1e-29 101.6 0.8 3.7 2 1 1 3 3 3 2 AAA domain AAA_12 PF13087.6 CDI75370.1 - 4.7e-54 183.0 0.0 9.6e-54 182.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDI75370.1 - 9.9e-11 42.2 0.2 0.00026 21.3 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 CDI75370.1 - 1.6e-09 37.8 5.1 0.0001 22.1 0.2 3.3 4 0 0 4 4 4 2 AAA domain Viral_helicase1 PF01443.18 CDI75370.1 - 0.0012 18.6 0.1 0.052 13.3 0.0 2.7 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 CDI75370.1 - 0.0088 15.6 0.0 3.4 7.1 0.1 3.4 3 1 1 4 4 4 1 UvrD/REP helicase N-terminal domain AAA_29 PF13555.6 CDI75370.1 - 0.053 13.3 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain UvrD_C_2 PF13538.6 CDI75370.1 - 0.092 12.6 0.0 0.34 10.8 0.0 2.1 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 CDI75370.1 - 0.18 12.2 1.7 0.54 10.6 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain RRM_1 PF00076.22 CDI75372.1 - 7.4e-37 125.0 0.2 4.7e-14 52.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDI75372.1 - 1.1e-05 25.2 0.0 0.11 12.4 0.0 3.5 3 0 0 3 3 3 2 Occluded RNA-recognition motif RBM39linker PF15519.6 CDI75372.1 - 1.6e-05 25.9 0.1 1.6e-05 25.9 0.1 3.1 3 0 0 3 3 3 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_3 PF08777.11 CDI75372.1 - 0.016 15.2 0.0 5.4 7.1 0.0 2.9 2 0 0 2 2 2 0 RNA binding motif DUF1866 PF08952.11 CDI75372.1 - 0.033 14.0 0.0 0.098 12.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) DbpA PF03880.15 CDI75372.1 - 0.1 12.6 0.9 18 5.4 0.0 3.6 3 0 0 3 3 3 0 DbpA RNA binding domain FUSC PF04632.12 CDI75372.1 - 1.1 7.7 4.0 1.9 6.9 4.0 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family PIP5K PF01504.18 CDI75373.1 - 8.8e-69 231.8 0.0 1.8e-68 230.7 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase EF-hand_1 PF00036.32 CDI75373.1 - 0.0001 21.6 0.4 0.00042 19.7 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 CDI75373.1 - 0.0028 18.1 1.0 0.012 16.1 0.5 2.4 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CDI75373.1 - 0.0096 15.8 0.1 0.043 13.8 0.1 2.1 1 0 0 1 1 1 1 EF-hand domain SUIM_assoc PF16619.5 CDI75373.1 - 5.4 7.2 6.5 18 5.5 6.5 1.9 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 zf-C3HC4_2 PF13923.6 CDI75374.1 - 1.3e-09 37.7 8.6 3.3e-09 36.4 8.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDI75374.1 - 2.7e-07 30.3 4.9 6.6e-07 29.1 4.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDI75374.1 - 5.4e-07 29.8 7.6 1.4e-06 28.5 7.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CDI75374.1 - 9.2e-07 28.8 8.0 3.8e-06 26.8 8.0 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CDI75374.1 - 9.8e-07 28.5 7.3 2.6e-06 27.2 7.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI75374.1 - 1.6e-06 27.9 5.2 5.4e-06 26.3 5.2 2.0 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDI75374.1 - 1.3e-05 25.0 6.0 3e-05 23.8 6.0 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 CDI75374.1 - 0.0001 22.1 1.4 0.00023 20.9 1.4 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 CDI75374.1 - 0.0012 19.0 10.6 0.0012 19.0 10.6 2.2 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING GYD PF08734.11 CDI75374.1 - 0.0071 16.3 2.2 0.0071 16.3 2.2 3.9 4 0 0 4 4 4 1 GYD domain zf-rbx1 PF12678.7 CDI75374.1 - 0.019 15.2 3.8 0.1 12.9 3.8 2.4 1 0 0 1 1 1 0 RING-H2 zinc finger domain SR-25 PF10500.9 CDI75374.1 - 0.02 14.5 0.7 0.02 14.5 0.7 11.0 9 3 2 11 11 8 0 Nuclear RNA-splicing-associated protein Peptidase_C97 PF05903.14 CDI75374.1 - 0.087 12.6 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 PPPDE putative peptidase domain zf-RING_4 PF14570.6 CDI75374.1 - 0.57 10.0 4.5 1.3 8.9 4.5 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Utp14 PF04615.13 CDI75377.1 - 8.2 4.9 79.3 11 4.5 79.3 1.1 1 0 0 1 1 1 0 Utp14 protein RskA PF10099.9 CDI75379.1 - 3.5e-07 30.7 2.2 3.5e-07 30.7 2.2 5.2 1 1 1 3 3 3 2 Anti-sigma-K factor rskA CpXC PF14353.6 CDI75379.1 - 0.00042 20.3 2.7 0.00042 20.3 2.7 3.1 3 1 0 3 3 3 1 CpXC protein zf-C2H2_4 PF13894.6 CDI75379.1 - 0.0011 19.6 6.3 0.0019 18.9 6.3 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger Cu2_monooxygen PF01082.20 CDI75379.1 - 0.027 14.7 1.6 0.027 14.7 1.6 2.6 2 1 0 2 2 2 0 Copper type II ascorbate-dependent monooxygenase, N-terminal domain zf-C2H2 PF00096.26 CDI75379.1 - 0.027 14.9 8.1 0.045 14.2 8.1 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type Activator_LAG-3 PF11498.8 CDI75379.1 - 0.12 11.3 68.6 0.017 14.1 10.5 2.6 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Rrn6 PF10214.9 CDI75379.1 - 1.6 7.2 34.6 0.76 8.2 28.0 2.1 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor zf-H2C2_2 PF13465.6 CDI75379.1 - 5.3 7.7 7.7 17 6.1 1.4 2.4 2 0 0 2 2 2 0 Zinc-finger double domain DUF2339 PF10101.9 CDI75380.1 - 2.7 6.5 45.7 4.1 5.9 43.7 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2339) BSP_II PF05432.11 CDI75381.1 - 0.059 13.1 9.7 0.073 12.8 9.7 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) RAP1 PF07218.11 CDI75381.1 - 0.078 11.3 7.5 0.079 11.2 7.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) JUPITER PF17054.5 CDI75381.1 - 0.1 12.0 12.3 0.12 11.8 12.3 1.0 1 0 0 1 1 1 0 Microtubule-Associated protein Jupiter Dsh_C PF12316.8 CDI75381.1 - 1.1 9.6 29.7 1.4 9.3 29.7 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal VCX_VCY PF15231.6 CDI75381.1 - 1.5 9.5 17.0 2.1 9.1 17.0 1.1 1 0 0 1 1 1 0 Variable charge X/Y family BAF1_ABF1 PF04684.13 CDI75381.1 - 2.3 7.2 27.3 2.7 6.9 27.3 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CCSAP PF15748.5 CDI75381.1 - 2.7 8.1 36.5 3 7.9 36.5 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated O-antigen_lig PF13425.6 CDI75381.1 - 7.7 5.2 7.5 9 5.0 7.5 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RIFIN PF02009.16 CDI75383.1 - 0.18 11.7 7.5 0.2 11.5 7.5 1.0 1 0 0 1 1 1 0 Rifin MID_MedPIWI PF18296.1 CDI75383.1 - 0.35 10.6 20.5 0.45 10.3 20.5 1.2 1 0 0 1 1 1 0 MID domain of medPIWI MGC-24 PF05283.11 CDI75383.1 - 1.3 9.5 24.2 1.6 9.2 24.2 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF1180 PF06679.12 CDI75383.1 - 2 8.8 20.0 2.8 8.3 20.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Apt1 PF10351.9 CDI75383.1 - 3.2 6.5 34.7 3.3 6.5 34.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Zip PF02535.22 CDI75383.1 - 4.3 6.5 16.4 5.1 6.2 16.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 CDI75383.1 - 5.6 5.6 19.3 6.1 5.5 19.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4366 PF14283.6 CDI75383.1 - 6 6.9 5.7 16 5.5 5.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) Band_3_cyto PF07565.13 CDI75383.1 - 7.4 6.3 12.7 8.1 6.2 12.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Macoilin PF09726.9 CDI75383.1 - 10 4.6 40.4 13 4.2 40.4 1.2 1 0 0 1 1 1 0 Macoilin family Glyco_hydro_9 PF00759.19 CDI75384.1 - 0.0023 17.5 2.2 0.0023 17.5 2.2 9.2 1 1 6 7 7 7 1 Glycosyl hydrolase family 9 DUF3807 PF12720.7 CDI75384.1 - 0.012 16.0 25.2 0.012 16.0 25.2 7.7 6 1 1 7 7 7 0 Protein of unknown function (DUF3807) LRR_6 PF13516.6 CDI75385.1 - 3.5e-05 23.5 1.5 0.53 10.5 0.0 3.6 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.7 CDI75385.1 - 0.049 14.1 0.3 0.35 11.4 0.1 2.3 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) DUF3800 PF12686.7 CDI75385.1 - 0.14 12.8 2.2 38 4.9 3.2 3.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) WD40 PF00400.32 CDI75386.1 - 0.3 12.0 2.3 11 7.1 0.8 2.8 2 1 0 2 2 2 0 WD domain, G-beta repeat RCSD PF05177.12 CDI75386.1 - 0.36 11.8 3.3 12 6.9 0.3 2.2 2 0 0 2 2 2 0 RCSD region AP2 PF00847.20 CDI75387.1 - 0.0033 17.6 0.8 0.0055 16.9 0.8 1.4 1 0 0 1 1 1 1 AP2 domain AP2 PF00847.20 CDI75388.1 - 1.6e-26 92.3 5.6 2.5e-11 43.6 0.2 3.7 3 0 0 3 3 3 3 AP2 domain ACDC PF14733.6 CDI75388.1 - 0.046 14.0 0.0 0.097 13.0 0.0 1.6 1 0 0 1 1 1 0 AP2-coincident C-terminal RT_RNaseH_2 PF17919.1 CDI75389.1 - 2.3e-08 34.0 0.0 3.4e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI75389.1 - 0.019 15.2 0.1 0.03 14.6 0.1 1.3 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Actin PF00022.19 CDI75390.1 - 5.3e-144 479.8 0.0 2.3e-143 477.7 0.0 1.7 1 1 0 1 1 1 1 Actin Pkinase PF00069.25 CDI75391.1 - 1.2e-48 165.7 0.0 1.7e-48 165.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI75391.1 - 3.7e-42 144.4 0.0 5.2e-42 143.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDI75391.1 - 0.017 14.1 0.3 0.029 13.3 0.3 1.3 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 CDI75391.1 - 0.022 14.4 0.0 0.04 13.5 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 CDI75391.1 - 0.06 12.7 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDI75391.1 - 0.067 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDI75391.1 - 0.089 11.6 0.5 4.5 5.9 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase Med21 PF11221.8 CDI75394.1 - 1.6e-11 44.6 0.8 2.1e-11 44.3 0.8 1.1 1 0 0 1 1 1 1 Subunit 21 of Mediator complex GCN5L1 PF06320.13 CDI75394.1 - 0.019 15.1 0.6 0.025 14.7 0.6 1.2 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) Med30 PF11315.8 CDI75394.1 - 0.053 13.7 0.5 0.095 12.9 0.5 1.4 1 1 0 1 1 1 0 Mediator complex subunit 30 UPF0184 PF03670.13 CDI75394.1 - 0.067 13.6 0.2 0.098 13.1 0.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) APG6_N PF17675.1 CDI75394.1 - 0.073 13.6 3.7 0.094 13.2 3.7 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF2291 PF10054.9 CDI75394.1 - 0.13 11.9 0.8 0.22 11.2 0.5 1.5 1 1 0 1 1 1 0 Predicted periplasmic lipoprotein (DUF2291) Usp PF00582.26 CDI75394.1 - 1.2 9.6 6.0 27 5.2 6.0 2.1 1 1 0 1 1 1 0 Universal stress protein family Ubiq_cyt_C_chap PF03981.12 CDI75395.1 - 0.00078 19.5 0.1 0.015 15.4 0.0 2.4 2 1 1 3 3 3 1 Ubiquinol-cytochrome C chaperone DHHC PF01529.20 CDI75396.1 - 0.0098 16.0 1.0 0.54 10.4 0.2 2.1 2 0 0 2 2 2 2 DHHC palmitoyltransferase SID-1_RNA_chan PF13965.6 CDI75396.1 - 0.14 10.5 1.1 0.17 10.3 1.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 IRK_C PF17655.1 CDI75398.1 - 2.6e-06 27.2 0.0 7.3e-06 25.7 0.0 1.6 1 1 1 2 2 2 1 Inward rectifier potassium channel C-terminal domain Dpy-30 PF05186.13 CDI75399.1 - 5.2e-13 48.5 0.7 1.3e-12 47.1 0.7 1.8 1 0 0 1 1 1 1 Dpy-30 motif SAM35 PF10806.8 CDI75399.1 - 0.042 14.1 0.0 0.076 13.3 0.0 1.4 1 0 0 1 1 1 0 SAM35, subunit of SAM coomplex Sporozoite_P67 PF05642.11 CDI75401.1 - 1.8e-06 26.4 7.4 1.8e-06 26.4 7.4 6.5 2 2 1 4 4 4 1 Sporozoite P67 surface antigen Tetraspanin PF00335.20 CDI75401.1 - 0.012 15.4 0.0 0.23 11.1 0.0 3.3 1 1 0 1 1 1 0 Tetraspanin family Zip PF02535.22 CDI75402.1 - 0.068 12.4 1.3 0.33 10.1 1.1 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4138 PF13595.6 CDI75402.1 - 0.23 10.7 5.3 0.13 11.5 2.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4138) ATP-grasp PF02222.22 CDI75402.1 - 0.34 10.5 0.1 0.34 10.5 0.1 3.4 2 1 1 3 3 3 0 ATP-grasp domain CAF1 PF04857.20 CDI75402.1 - 0.54 9.4 7.6 44 3.1 7.8 3.0 1 1 0 1 1 1 0 CAF1 family ribonuclease SID-1_RNA_chan PF13965.6 CDI75402.1 - 1.4 7.3 4.8 5.9 5.2 3.0 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 M_domain PF12938.7 CDI75403.1 - 0.61 9.8 27.7 0.75 9.5 27.7 1.2 1 0 0 1 1 1 0 M domain of GW182 Spt20 PF12090.8 CDI75403.1 - 3 7.4 17.2 3.7 7.1 17.2 1.2 1 0 0 1 1 1 0 Spt20 family SARAF PF06682.12 CDI75404.1 - 0.085 12.5 9.1 0.09 12.4 9.1 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DivIC PF04977.15 CDI75404.1 - 0.22 11.3 25.7 0.19 11.5 8.8 2.1 2 0 0 2 2 2 0 Septum formation initiator DUF4820 PF16091.5 CDI75404.1 - 0.47 9.8 11.3 0.6 9.4 11.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Chordopox_A13L PF05961.11 CDI75404.1 - 0.55 10.5 0.1 0.55 10.5 0.1 2.0 2 0 0 2 2 2 0 Chordopoxvirus A13L protein CLN3 PF02487.17 CDI75404.1 - 2.5 7.1 6.4 2.7 6.9 6.4 1.0 1 0 0 1 1 1 0 CLN3 protein BES1_N PF05687.13 CDI75404.1 - 2.8 8.3 6.5 2.6 8.4 5.9 1.3 1 1 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal Senescence_reg PF04520.13 CDI75404.1 - 3.1 8.6 11.6 3.9 8.3 11.6 1.1 1 0 0 1 1 1 0 Senescence regulator Gti1_Pac2 PF09729.9 CDI75404.1 - 5.5 7.0 9.7 7 6.7 9.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Presenilin PF01080.17 CDI75404.1 - 8.6 5.0 12.3 9.7 4.8 12.3 1.1 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 CDI75405.1 - 0.0023 17.6 13.2 0.0028 17.3 13.2 1.1 1 0 0 1 1 1 1 Spt20 family Ribosomal_60s PF00428.19 CDI75405.1 - 0.13 12.9 20.3 0.94 10.1 6.9 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Sporozoite_P67 PF05642.11 CDI75405.1 - 0.17 9.9 15.1 0.16 10.0 14.6 1.3 1 1 0 1 1 1 0 Sporozoite P67 surface antigen DUF1712 PF08217.11 CDI75405.1 - 1.5 7.2 4.9 1.6 7.1 4.9 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1712) Plasmodium_Vir PF05795.11 CDI75405.1 - 1.6 8.1 6.0 1.9 7.9 6.0 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Lin-8 PF03353.15 CDI75405.1 - 1.6 8.2 10.9 1.7 8.1 10.9 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SOG2 PF10428.9 CDI75405.1 - 1.6 7.8 25.6 1.9 7.6 25.6 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein MAP65_ASE1 PF03999.12 CDI75405.1 - 1.8 7.1 15.1 1.9 7.1 15.1 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Apt1 PF10351.9 CDI75405.1 - 2.1 7.1 10.7 2.3 6.9 10.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peroxin-3 PF04882.12 CDI75405.1 - 2.9 6.8 12.6 2.9 6.8 12.6 1.1 1 0 0 1 1 1 0 Peroxin-3 Presenilin PF01080.17 CDI75405.1 - 3.8 6.2 9.3 4.2 6.0 9.3 1.3 1 0 0 1 1 1 0 Presenilin SR-25 PF10500.9 CDI75405.1 - 4.1 7.0 25.5 0.42 10.2 20.1 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein BAF1_ABF1 PF04684.13 CDI75405.1 - 4.4 6.3 12.7 5.9 5.8 12.7 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Mcm10 PF09332.11 CDI75405.1 - 7.9 5.8 13.1 8.8 5.6 13.1 1.0 1 0 0 1 1 1 0 Mcm10 replication factor Peptidase_S64 PF08192.11 CDI75405.1 - 8.7 4.7 12.1 8.8 4.7 12.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 IFT57 PF10498.9 CDI75406.1 - 8.2e-12 44.8 0.0 1.4e-05 24.3 0.1 2.1 2 0 0 2 2 2 2 Intra-flagellar transport protein 57 Retrotrans_gag PF03732.17 CDI75406.1 - 0.0063 16.8 0.4 0.019 15.3 0.0 2.0 2 0 0 2 2 2 1 Retrotransposon gag protein DUF883 PF05957.13 CDI75406.1 - 0.031 14.9 5.2 0.2 12.3 2.0 2.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Mt_ATP-synt_B PF05405.14 CDI75406.1 - 0.07 12.7 1.7 0.13 11.9 1.7 1.4 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Spc7 PF08317.11 CDI75406.1 - 0.35 9.7 5.7 0.55 9.1 5.7 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4200 PF13863.6 CDI75406.1 - 2 8.9 8.2 1.9 8.9 5.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) CCDC-167 PF15188.6 CDI75406.1 - 2.9 8.3 6.2 2.8 8.4 4.3 2.0 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 Jnk-SapK_ap_N PF09744.9 CDI75406.1 - 6.9 6.9 11.4 14 5.9 6.0 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF445 PF04286.12 CDI75407.1 - 0.0012 18.7 38.5 0.012 15.5 28.9 2.7 1 1 1 2 2 2 2 Protein of unknown function (DUF445) DUF5314 PF17241.2 CDI75407.1 - 0.017 14.8 13.5 0.2 11.3 1.9 3.6 1 1 1 2 2 2 0 Family of unknown function (DUF5314) DUF2939 PF11159.8 CDI75407.1 - 0.12 12.9 4.1 6.7 7.2 0.1 3.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2939) DUF2884 PF11101.8 CDI75407.1 - 0.12 11.8 30.0 1.5 8.2 13.7 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2884) COMPASS-Shg1 PF05205.12 CDI75407.1 - 0.17 12.6 26.3 1.8e+04 -3.9 26.3 3.4 1 1 0 1 1 0 0 COMPASS (Complex proteins associated with Set1p) component shg1 DinB_2 PF12867.7 CDI75407.1 - 0.18 12.3 3.1 29 5.2 3.1 3.4 1 1 0 1 1 1 0 DinB superfamily EcsC PF12787.7 CDI75407.1 - 0.27 10.9 14.8 4.2e+02 0.4 14.8 3.1 1 1 0 1 1 1 0 EcsC protein family SecA_SW PF07516.13 CDI75407.1 - 0.34 10.9 30.3 1.8e+04 -5.5 30.2 2.7 1 1 0 1 1 0 0 SecA Wing and Scaffold domain YpjP PF14005.6 CDI75407.1 - 0.49 10.4 32.3 4.1 7.5 1.7 4.1 1 1 2 3 3 3 0 YpjP-like protein Spo0A_C PF08769.11 CDI75407.1 - 1 9.5 17.9 8.8 6.5 4.4 3.6 1 1 2 3 3 3 0 Sporulation initiation factor Spo0A C terminal DUF3819 PF12842.7 CDI75407.1 - 1.2 9.1 25.1 0.9 9.5 15.9 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3819) ATC_hydrolase PF14196.6 CDI75407.1 - 1.2 9.9 12.3 41 4.9 0.5 3.2 1 1 1 2 2 2 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase CBFD_NFYB_HMF PF00808.23 CDI75407.1 - 1.7 9.0 40.1 40 4.6 2.5 5.9 1 1 1 2 2 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PIN_8 PF18476.1 CDI75407.1 - 1.9 8.3 29.3 7 6.4 12.7 2.4 1 1 1 2 2 2 0 PIN like domain DUF637 PF04830.13 CDI75407.1 - 2.1 8.1 7.8 1.2e+02 2.5 7.8 2.5 1 1 0 1 1 1 0 Possible hemagglutinin (DUF637) CEL_III_C PF18054.1 CDI75407.1 - 2.7 8.1 30.5 8.6 6.4 12.5 2.7 1 1 2 3 3 3 0 CEL-III C-terminal CelTOS PF18659.1 CDI75407.1 - 2.7 8.4 20.1 8e+03 -2.8 20.1 3.4 1 1 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites Cornifin PF02389.15 CDI75407.1 - 4.7 7.4 12.0 9.2 6.5 12.0 1.6 1 1 0 1 1 1 0 Cornifin (SPRR) family Presenilin PF01080.17 CDI75408.1 - 0.00017 20.5 9.6 0.00026 19.9 9.6 1.3 1 0 0 1 1 1 1 Presenilin SpoIIIAH PF12685.7 CDI75408.1 - 0.00051 19.9 3.6 0.00051 19.9 3.6 1.9 2 0 0 2 2 2 1 SpoIIIAH-like protein SID-1_RNA_chan PF13965.6 CDI75408.1 - 0.017 13.6 1.0 0.023 13.1 1.0 1.2 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 PIP5K PF01504.18 CDI75408.1 - 0.032 13.5 3.0 0.033 13.4 3.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase NPR3 PF03666.13 CDI75408.1 - 0.039 12.8 8.6 0.051 12.4 8.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Hamartin PF04388.12 CDI75408.1 - 0.078 11.6 11.9 0.098 11.3 11.9 1.2 1 0 0 1 1 1 0 Hamartin protein SOG2 PF10428.9 CDI75408.1 - 0.097 11.9 12.5 0.13 11.4 12.5 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein SAPS PF04499.15 CDI75408.1 - 0.14 10.9 6.4 0.16 10.7 6.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MDM10 PF12519.8 CDI75408.1 - 0.16 10.8 5.0 0.2 10.5 5.0 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Tim54 PF11711.8 CDI75408.1 - 0.37 9.5 15.6 0.56 8.9 15.6 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SARAF PF06682.12 CDI75408.1 - 0.58 9.7 15.2 1 8.9 15.2 1.5 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Peroxin-3 PF04882.12 CDI75408.1 - 0.63 9.0 12.7 0.81 8.6 12.7 1.3 1 0 0 1 1 1 0 Peroxin-3 DUF4131 PF13567.6 CDI75408.1 - 0.68 9.6 11.8 45 3.6 11.8 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) FAM60A PF15396.6 CDI75408.1 - 0.96 9.4 10.2 1.4 8.8 10.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Vac7 PF12751.7 CDI75408.1 - 1.1 8.6 8.1 2 7.8 8.1 1.5 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 Zip PF02535.22 CDI75408.1 - 1.8 7.7 7.8 4 6.6 7.8 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter PPP4R2 PF09184.11 CDI75408.1 - 2.3 7.7 16.3 2.9 7.4 16.3 1.1 1 0 0 1 1 1 0 PPP4R2 CLN3 PF02487.17 CDI75408.1 - 2.8 6.9 9.6 5.2 6.0 8.6 1.7 2 0 0 2 2 2 0 CLN3 protein SMYLE_N PF18615.1 CDI75408.1 - 2.8 7.4 12.3 4.2 6.8 12.3 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain CCSAP PF15748.5 CDI75408.1 - 3 8.0 21.4 5 7.2 21.4 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated VIR_N PF15912.5 CDI75408.1 - 3.4 7.2 17.9 5.2 6.6 17.9 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal OATP PF03137.20 CDI75408.1 - 3.6 5.8 5.1 6.2 5.0 5.1 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family NOA36 PF06524.12 CDI75408.1 - 4.8 6.4 10.0 6.8 5.9 10.0 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4746 PF15928.5 CDI75408.1 - 6.8 6.0 15.5 10 5.4 15.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Neur_chan_memb PF02932.16 CDI75408.1 - 8.4 6.4 13.4 15 5.6 13.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FHA PF00498.26 CDI75409.1 - 0.0015 18.8 0.0 0.0015 18.8 0.0 2.1 2 0 0 2 2 2 1 FHA domain Caldesmon PF02029.15 CDI75409.1 - 0.003 16.4 9.6 0.003 16.4 9.6 3.1 3 0 0 3 3 3 3 Caldesmon Rtt106 PF08512.12 CDI75411.1 - 1.6e-24 86.2 0.1 5.1e-24 84.5 0.0 1.8 2 0 0 2 2 2 1 Histone chaperone Rttp106-like YL1 PF05764.13 CDI75411.1 - 0.0012 19.1 26.8 0.0012 19.1 26.8 1.4 2 0 0 2 2 2 1 YL1 nuclear protein Nop53 PF07767.11 CDI75411.1 - 0.099 12.0 21.6 0.16 11.3 21.6 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CCDC106 PF15794.5 CDI75411.1 - 0.68 9.6 12.5 1 9.1 12.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Nop14 PF04147.12 CDI75411.1 - 3.3 5.8 23.8 4.1 5.5 23.8 1.1 1 0 0 1 1 1 0 Nop14-like family PGA2 PF07543.12 CDI75411.1 - 5.7 6.9 16.8 10 6.1 16.8 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 RNA_pol_Rpc4 PF05132.14 CDI75413.1 - 3e-23 82.9 0.1 3e-23 82.9 0.1 3.3 3 1 0 3 3 3 1 RNA polymerase III RPC4 Presenilin PF01080.17 CDI75413.1 - 9.1 4.9 9.0 0.38 9.5 0.9 2.1 2 0 0 2 2 2 0 Presenilin AP2 PF00847.20 CDI75415.1 - 6.2e-12 45.6 0.1 1.9e-11 44.0 0.1 1.9 1 0 0 1 1 1 1 AP2 domain DUF4200 PF13863.6 CDI75417.1 - 3.6e-24 85.5 11.6 3.6e-24 85.5 11.6 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4200) Orbi_VP5 PF00901.17 CDI75417.1 - 0.0023 16.4 3.7 0.0023 16.4 3.7 1.8 2 0 0 2 2 2 1 Orbivirus outer capsid protein VP5 Prefoldin_2 PF01920.20 CDI75418.1 - 0.0089 16.0 1.4 0.0089 16.0 1.4 2.0 2 1 0 2 2 2 1 Prefoldin subunit Vir_act_alpha_C PF10400.9 CDI75418.1 - 0.015 16.0 5.7 0.19 12.5 1.5 2.3 2 0 0 2 2 2 0 Virulence activator alpha C-term Caps_synth_GfcC PF06251.11 CDI75418.1 - 0.029 14.0 1.2 0.033 13.8 1.2 1.0 1 0 0 1 1 1 0 Capsule biosynthesis GfcC GrpE PF01025.19 CDI75418.1 - 0.041 13.6 3.8 0.051 13.2 3.8 1.2 1 1 0 1 1 1 0 GrpE DUF16 PF01519.16 CDI75418.1 - 0.044 14.3 2.1 0.11 13.0 2.1 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 Mt_ATP-synt_B PF05405.14 CDI75418.1 - 0.054 13.1 3.2 0.07 12.8 3.2 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Ntox28 PF15605.6 CDI75418.1 - 0.069 13.4 0.7 0.12 12.6 0.3 1.6 2 0 0 2 2 2 0 Bacterial toxin 28 COG2 PF06148.11 CDI75418.1 - 0.11 12.6 2.6 0.23 11.6 2.5 1.7 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3016 PF11454.8 CDI75418.1 - 0.11 12.2 0.3 3.4 7.4 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3016) Spc7 PF08317.11 CDI75418.1 - 0.2 10.5 5.5 0.2 10.5 5.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF724 PF05266.14 CDI75418.1 - 0.2 11.5 4.3 0.16 11.8 3.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF4407 PF14362.6 CDI75418.1 - 0.37 10.1 6.7 0.45 9.8 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 CDI75418.1 - 0.43 11.2 7.8 0.34 11.6 5.4 2.0 2 0 0 2 2 2 0 SlyX ABC_tran_CTD PF16326.5 CDI75418.1 - 2.1 8.7 10.0 3.6 7.9 6.1 2.4 2 1 0 2 2 2 0 ABC transporter C-terminal domain Spc24 PF08286.11 CDI75418.1 - 3 8.1 5.6 2.4 8.4 3.1 1.8 1 1 0 2 2 2 0 Spc24 subunit of Ndc80 PRP38_assoc PF12871.7 CDI75420.1 - 0.13 12.9 92.1 1.7 9.3 54.6 2.6 1 1 1 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Trypan_PARP PF05887.11 CDI75420.1 - 2.5 8.1 20.1 4.3 7.3 9.1 2.0 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) Asp-B-Hydro_N PF05279.11 CDI75421.1 - 1.4 8.9 50.8 0.12 12.4 42.4 2.2 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region tRNA-synt_2b PF00587.25 CDI75422.1 - 5.4e-09 36.3 0.8 5.7e-06 26.4 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) TFIIA PF03153.13 CDI75422.1 - 4.3e-05 23.7 42.2 0.005 16.9 15.5 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit CAF1 PF04857.20 CDI75422.1 - 0.0016 17.6 1.5 0.0021 17.3 1.5 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease Gti1_Pac2 PF09729.9 CDI75422.1 - 0.0024 18.0 3.7 0.41 10.7 0.9 2.1 2 0 0 2 2 2 2 Gti1/Pac2 family CCDC53 PF10152.9 CDI75422.1 - 0.0077 16.7 12.6 0.045 14.2 0.5 2.1 2 0 0 2 2 2 1 Subunit CCDC53 of WASH complex EPL1 PF10513.9 CDI75422.1 - 0.0085 16.5 14.2 0.056 13.8 0.2 2.1 2 0 0 2 2 2 1 Enhancer of polycomb-like Pex14_N PF04695.13 CDI75422.1 - 0.01 16.5 31.3 0.13 12.9 9.1 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Velvet PF11754.8 CDI75422.1 - 0.014 15.3 12.6 0.16 11.9 1.6 2.1 2 0 0 2 2 2 0 Velvet factor SpoIIP PF07454.11 CDI75422.1 - 0.015 14.8 12.5 0.21 11.0 3.4 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Lin-8 PF03353.15 CDI75422.1 - 0.035 13.7 17.8 0.034 13.7 2.5 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF2956 PF11169.8 CDI75422.1 - 0.051 13.8 31.5 0.054 13.7 11.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) FAM176 PF14851.6 CDI75422.1 - 0.054 13.2 6.4 0.075 12.7 0.7 2.1 2 0 0 2 2 2 0 FAM176 family Ctr PF04145.15 CDI75422.1 - 0.071 13.7 7.9 2.4 8.8 2.5 2.1 2 0 0 2 2 2 0 Ctr copper transporter family DUF2722 PF10846.8 CDI75422.1 - 0.13 11.2 43.8 0.4 9.6 13.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) RPA43_OB PF17875.1 CDI75422.1 - 0.14 12.8 6.3 0.36 11.4 0.6 2.3 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Suf PF05843.14 CDI75422.1 - 0.14 12.1 24.3 0.28 11.1 8.8 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) PIP5K PF01504.18 CDI75422.1 - 0.25 10.5 12.4 0.39 9.9 0.4 2.0 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase UPF0560 PF10577.9 CDI75422.1 - 0.27 9.7 26.4 0.31 9.5 8.3 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 Peroxin-13_N PF04088.13 CDI75422.1 - 0.35 11.1 8.2 1.1 9.5 0.6 2.2 2 0 0 2 2 2 0 Peroxin 13, N-terminal region DUF913 PF06025.12 CDI75422.1 - 0.54 9.2 9.0 0.079 11.9 0.5 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Eapp_C PF10238.9 CDI75422.1 - 0.65 10.1 21.4 0.6 10.2 6.2 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein RNA_pol_Rbc25 PF08292.12 CDI75422.1 - 0.75 10.0 11.1 0.15 12.3 1.2 2.3 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 FAM60A PF15396.6 CDI75422.1 - 0.76 9.7 10.7 3 7.8 3.2 2.2 2 0 0 2 2 2 0 Protein Family FAM60A CPSF100_C PF13299.6 CDI75422.1 - 0.78 9.9 13.9 0.45 10.7 1.9 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF2076 PF09849.9 CDI75422.1 - 1.1 9.3 38.8 2.3 8.2 14.6 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF1644 PF07800.12 CDI75422.1 - 1.1 9.3 14.3 0.89 9.6 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) GxGYxYP_C PF14323.6 CDI75422.1 - 1.2 8.9 6.3 1.9 8.3 0.1 2.1 2 0 0 2 2 2 0 GxGYxYP putative glycoside hydrolase C-terminal domain EIIBC-GUT_N PF03612.14 CDI75422.1 - 1.4 8.7 18.0 0.16 11.7 3.7 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus PPL5 PF18168.1 CDI75422.1 - 1.6 7.9 10.5 0.2 10.9 0.6 2.1 2 0 0 2 2 2 0 Prim-pol family 5 Rxt3 PF08642.10 CDI75422.1 - 1.7 9.4 10.4 1.7 9.4 1.9 2.2 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 MMU163 PF17119.5 CDI75422.1 - 1.7 7.7 8.0 0.9 8.6 1.0 2.1 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis Spore_coat_CotO PF14153.6 CDI75422.1 - 1.7 8.5 29.3 2.5 8.0 7.5 2.1 2 0 0 2 2 2 0 Spore coat protein CotO PAT1 PF09770.9 CDI75422.1 - 1.7 6.8 33.2 1.6 6.9 12.3 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Connexin PF00029.19 CDI75422.1 - 1.8 8.2 13.9 1.2 8.8 2.8 2.1 2 0 0 2 2 2 0 Connexin Kei1 PF08552.11 CDI75422.1 - 2 8.2 8.4 4.8 7.0 0.5 2.1 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Renin_r PF07850.14 CDI75422.1 - 2.1 9.0 8.9 6.9 7.3 0.5 2.2 2 0 0 2 2 2 0 Renin receptor-like protein DUF4770 PF15994.5 CDI75422.1 - 2.2 8.5 22.4 0.9 9.7 2.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) GWT1 PF06423.12 CDI75422.1 - 2.3 8.3 3.2 60 3.7 0.2 3.1 3 0 0 3 3 3 0 GWT1 DUF719 PF05334.13 CDI75422.1 - 2.6 8.2 13.8 0.57 10.3 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF719) VIT1 PF01988.19 CDI75422.1 - 2.8 7.7 3.5 16 5.3 0.8 2.1 2 0 0 2 2 2 0 VIT family Plasmodium_Vir PF05795.11 CDI75422.1 - 3.1 7.1 5.7 3.7 6.9 0.8 2.0 2 0 0 2 2 2 0 Plasmodium vivax Vir protein CLN3 PF02487.17 CDI75422.1 - 3.2 6.7 12.0 0.68 8.9 0.9 2.1 2 0 0 2 2 2 0 CLN3 protein Peptidase_S49_N PF08496.10 CDI75422.1 - 3.7 7.6 18.6 3.6 7.6 1.9 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF868 PF05910.12 CDI75422.1 - 3.9 7.0 11.7 1 8.9 2.6 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF868) DUF4834 PF16118.5 CDI75422.1 - 4 8.5 26.4 0.65 11.0 8.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Coilin_N PF15862.5 CDI75422.1 - 4.9 7.0 23.1 1.1 9.0 8.5 3.0 3 0 0 3 3 3 0 Coilin N-terminus Zip PF02535.22 CDI75422.1 - 5 6.2 7.2 7.4 5.7 0.2 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter DUF2828 PF11443.8 CDI75422.1 - 5.3 5.0 14.3 0.28 9.2 2.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) BORG_CEP PF14957.6 CDI75422.1 - 5.5 8.2 13.4 4.8 8.4 1.8 2.2 2 0 0 2 2 2 0 Cdc42 effector Med15 PF09606.10 CDI75422.1 - 5.6 5.5 48.0 0.4 9.3 17.3 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal PepSY_TM PF03929.16 CDI75422.1 - 6.3 6.4 11.4 7.3 6.2 0.8 2.1 2 0 0 2 2 2 0 PepSY-associated TM region OATP PF03137.20 CDI75422.1 - 6.4 4.9 9.6 2.5 6.3 3.0 2.0 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Orf78 PF06024.12 CDI75422.1 - 6.5 7.1 11.7 5.2 7.4 2.4 2.3 2 0 0 2 2 2 0 Orf78 (ac78) DUF3408 PF11888.8 CDI75422.1 - 7.6 6.7 23.2 1.9 8.6 7.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) BRF1 PF07741.13 CDI75422.1 - 7.7 6.9 15.3 16 5.9 7.5 2.3 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Spt20 PF12090.8 CDI75422.1 - 7.8 6.0 67.0 7.6 6.1 30.4 2.2 2 0 0 2 2 2 0 Spt20 family DUF2464 PF10240.9 CDI75422.1 - 8.3 5.9 15.3 0.87 9.1 1.3 2.1 2 0 0 2 2 2 0 Multivesicular body subunit 12 LMBR1 PF04791.16 CDI75424.1 - 0.0017 17.4 4.3 0.0021 17.1 4.3 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein SUIM_assoc PF16619.5 CDI75424.1 - 0.0043 17.1 4.7 0.0043 17.1 4.7 4.4 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 AAA_8 PF12780.7 CDI75425.1 - 2.4e-17 63.1 16.7 4.1e-17 62.4 11.7 3.2 2 1 0 2 2 1 1 P-loop containing dynein motor region D4 Activator_LAG-3 PF11498.8 CDI75425.1 - 2.5e-07 30.1 38.8 2.5e-07 30.1 38.8 1.8 2 0 0 2 2 2 1 Transcriptional activator LAG-3 Macoilin PF09726.9 CDI75425.1 - 0.0011 17.6 31.2 0.0016 17.1 31.2 1.2 1 0 0 1 1 1 1 Macoilin family Serinc PF03348.15 CDI75425.1 - 0.0014 17.7 12.9 0.0014 17.7 12.9 1.6 2 0 0 2 2 2 1 Serine incorporator (Serinc) SR-25 PF10500.9 CDI75425.1 - 0.0015 18.2 10.4 0.0015 18.2 10.4 3.2 2 1 1 3 3 1 1 Nuclear RNA-splicing-associated protein SprA-related PF12118.8 CDI75425.1 - 0.0024 17.1 32.2 0.0024 17.1 32.2 2.7 2 1 0 2 2 1 1 SprA-related family AAA_lid_1 PF17857.1 CDI75425.1 - 0.0033 17.6 0.0 0.0096 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain DDRGK PF09756.9 CDI75425.1 - 0.047 13.3 19.6 0.12 11.9 19.6 1.7 1 0 0 1 1 1 0 DDRGK domain Presenilin PF01080.17 CDI75425.1 - 0.087 11.6 31.6 0.024 13.4 17.5 2.1 2 0 0 2 2 2 0 Presenilin Hamartin PF04388.12 CDI75425.1 - 0.14 10.7 28.1 0.18 10.4 28.1 1.2 1 0 0 1 1 1 0 Hamartin protein PBP_sp32 PF07222.12 CDI75425.1 - 0.3 10.5 22.5 0.67 9.4 22.5 1.6 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF2126 PF09899.9 CDI75425.1 - 0.33 9.0 9.1 0.48 8.4 9.1 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF1682 PF07946.14 CDI75425.1 - 0.33 10.1 13.2 0.66 9.1 13.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) TCP PF03634.13 CDI75425.1 - 0.47 11.0 34.1 0.097 13.2 20.8 2.4 2 0 0 2 2 2 0 TCP family transcription factor DUF2052 PF09747.9 CDI75425.1 - 0.48 10.5 26.2 0.4 10.8 17.6 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) RR_TM4-6 PF06459.12 CDI75425.1 - 0.56 10.0 22.7 0.016 15.0 14.0 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RP-C_C PF11800.8 CDI75425.1 - 0.77 9.8 22.9 0.87 9.6 13.5 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region SOBP PF15279.6 CDI75425.1 - 0.84 10.2 27.8 0.23 12.1 15.4 2.2 2 0 0 2 2 2 0 Sine oculis-binding protein SpoIIP PF07454.11 CDI75425.1 - 1.2 8.5 21.1 0.14 11.6 15.0 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Vfa1 PF08432.10 CDI75425.1 - 1.3 9.3 22.1 0.64 10.3 12.7 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 RAP1 PF07218.11 CDI75425.1 - 1.3 7.2 27.1 1.1 7.5 17.6 2.1 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) LMBR1 PF04791.16 CDI75425.1 - 1.3 7.8 9.4 1.5 7.6 9.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein CSG2 PF16965.5 CDI75425.1 - 1.4 7.8 22.1 0.2 10.5 16.1 2.0 2 0 0 2 2 2 0 Ceramide synthase regulator MetallophosC PF16370.5 CDI75425.1 - 1.5 9.0 9.2 2.8 8.2 5.6 2.2 2 0 0 2 2 2 0 C terminal of Calcineurin-like phosphoesterase Peptidase_S49_N PF08496.10 CDI75425.1 - 1.6 8.8 15.0 0.48 10.5 12.0 1.7 2 0 0 2 2 1 0 Peptidase family S49 N-terminal DUF4746 PF15928.5 CDI75425.1 - 1.6 8.1 11.3 3.4 7.0 11.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Ureide_permease PF07168.11 CDI75425.1 - 1.9 7.2 7.0 4.1 6.1 7.0 1.5 1 0 0 1 1 1 0 Ureide permease PPL5 PF18168.1 CDI75425.1 - 1.9 7.7 18.2 0.11 11.8 11.1 2.1 2 0 0 2 2 2 0 Prim-pol family 5 DUF4407 PF14362.6 CDI75425.1 - 2 7.7 23.0 2.3 7.5 15.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF5523 PF17661.1 CDI75425.1 - 2.5 7.7 22.2 0.46 10.1 14.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) PepSY_TM PF03929.16 CDI75425.1 - 2.5 7.7 10.8 2.8 7.5 7.7 2.0 2 0 0 2 2 2 0 PepSY-associated TM region Nucleoside_tran PF01733.18 CDI75425.1 - 3 7.1 4.6 5.1 6.4 4.6 1.4 1 0 0 1 1 1 0 Nucleoside transporter Peroxin-3 PF04882.12 CDI75425.1 - 3 6.7 40.5 2.3 7.1 8.2 2.1 2 0 0 2 2 2 0 Peroxin-3 PNISR PF15996.5 CDI75425.1 - 3.2 8.0 31.0 1.2 9.4 19.6 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR SID-1_RNA_chan PF13965.6 CDI75425.1 - 4.1 5.7 15.3 0.44 8.9 8.6 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Neur_chan_memb PF02932.16 CDI75425.1 - 4.1 7.4 24.5 4 7.4 16.6 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Spc7_N PF15402.6 CDI75425.1 - 4.4 5.4 42.3 0.28 9.4 19.1 2.0 2 0 0 2 2 2 0 N-terminus of kinetochore NMS complex subunit Spc7 SLC12 PF03522.15 CDI75425.1 - 4.5 6.2 27.3 1.4 7.8 18.9 2.1 2 0 0 2 2 2 0 Solute carrier family 12 SSP160 PF06933.11 CDI75425.1 - 4.6 5.3 26.8 2.9 6.0 2.9 2.1 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 MID_MedPIWI PF18296.1 CDI75425.1 - 5 6.8 30.7 5.3 6.8 3.0 2.3 2 0 0 2 2 2 0 MID domain of medPIWI DUF4471 PF14740.6 CDI75425.1 - 5.6 6.1 15.3 0.51 9.5 10.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) DUF4175 PF13779.6 CDI75425.1 - 6.1 4.6 41.7 0.28 9.0 34.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) Ndc1_Nup PF09531.10 CDI75425.1 - 6.2 5.4 25.1 2.9 6.5 15.2 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Sin_N PF04801.13 CDI75425.1 - 6.2 5.9 34.3 2.7 7.1 24.4 2.1 2 0 0 2 2 2 0 Sin-like protein conserved region FapA PF03961.13 CDI75425.1 - 6.3 5.3 12.1 8.5 4.8 12.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Connexin PF00029.19 CDI75425.1 - 7.1 6.3 15.2 0.86 9.3 10.3 1.8 2 0 0 2 2 2 0 Connexin 7tm_7 PF08395.12 CDI75425.1 - 8 5.6 6.1 13 4.9 6.1 1.3 1 0 0 1 1 1 0 7tm Chemosensory receptor TFIIA PF03153.13 CDI75425.1 - 8 6.3 62.4 23 4.8 62.4 1.6 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI75425.1 - 8.5 4.9 42.2 2 7.0 33.7 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Peptidase_S15 PF02129.18 CDI75425.1 - 8.9 5.8 14.9 2.2 7.8 10.0 2.0 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) OATP PF03137.20 CDI75425.1 - 9 4.4 10.2 1.3 7.2 5.3 1.9 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family GD_AH_C PF04295.13 CDI75425.1 - 9.3 4.9 12.6 1.3 7.7 8.9 1.4 2 0 0 2 2 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus CitMHS PF03600.16 CDI75426.1 - 6.5e-07 28.8 0.0 7.4e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Citrate transporter Macoilin PF09726.9 CDI75426.1 - 0.0043 15.7 36.0 0.0072 14.9 36.0 1.3 1 0 0 1 1 1 1 Macoilin family Caldesmon PF02029.15 CDI75426.1 - 0.029 13.1 42.4 0.037 12.8 42.4 1.1 1 0 0 1 1 1 0 Caldesmon GREB1 PF15782.5 CDI75426.1 - 0.042 11.0 47.4 0.053 10.7 47.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF572 PF04502.13 CDI75426.1 - 0.43 10.2 38.5 0.78 9.3 38.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF5427 PF10310.9 CDI75426.1 - 0.9 8.4 42.3 1.3 7.9 42.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5427) PA26 PF04636.13 CDI75426.1 - 0.97 8.3 28.6 1.3 7.8 28.6 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Asp-B-Hydro_N PF05279.11 CDI75426.1 - 1.2 9.1 30.9 1.8 8.6 30.9 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Plasmodium_Vir PF05795.11 CDI75426.1 - 2.7 7.3 27.9 5.4 6.3 27.9 1.5 1 1 0 1 1 1 0 Plasmodium vivax Vir protein PAT1 PF09770.9 CDI75426.1 - 3.4 5.8 74.8 4.4 5.4 74.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Draxin PF15550.6 CDI75426.1 - 4.6 7.0 29.6 5.9 6.7 29.6 1.1 1 0 0 1 1 1 0 Draxin Ndc1_Nup PF09531.10 CDI75427.1 - 0.12 11.1 1.2 0.15 10.7 1.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RNase_J_C PF17770.1 CDI75427.1 - 2.5 9.2 18.4 8.1 7.6 1.1 3.5 1 1 2 3 3 3 0 Ribonuclease J C-terminal domain Spore_SspJ PF09575.10 CDI75427.1 - 4.5 7.7 4.9 3 8.3 1.0 2.7 1 1 2 3 3 3 0 Small spore protein J (Spore_SspJ) Tam41_Mmp37 PF09139.11 CDI75427.1 - 5 6.5 7.6 19 4.6 7.6 1.8 1 1 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial DUF2722 PF10846.8 CDI75428.1 - 0.00018 20.6 12.9 0.00018 20.6 12.9 11.1 3 2 6 9 9 9 1 Protein of unknown function (DUF2722) Myosin_head PF00063.21 CDI75430.1 - 1.8e-119 399.9 0.1 3.9e-89 299.7 0.0 3.3 3 0 0 3 3 3 3 Myosin head (motor domain) AAA_22 PF13401.6 CDI75430.1 - 0.19 12.0 1.7 1.3 9.3 0.1 3.2 3 0 0 3 3 3 0 AAA domain Myosin_head PF00063.21 CDI75431.1 - 1.6e-134 449.7 0.1 1.4e-92 311.1 0.0 3.2 3 0 0 3 3 3 3 Myosin head (motor domain) AAA_22 PF13401.6 CDI75431.1 - 0.025 14.9 2.0 0.57 10.5 0.1 3.3 3 0 0 3 3 3 0 AAA domain FlaG PF03646.15 CDI75431.1 - 0.13 12.4 0.0 1.8 8.8 0.0 2.9 2 0 0 2 2 2 0 FlaG protein Zeta_toxin PF06414.12 CDI75431.1 - 0.14 11.4 1.4 0.46 9.7 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Fmp27_WPPW PF10359.9 CDI75432.1 - 0.027 13.3 23.5 0.034 13.0 23.5 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Presenilin PF01080.17 CDI75432.1 - 0.045 12.5 26.8 0.052 12.3 26.8 1.0 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI75432.1 - 0.099 12.5 24.4 0.14 12.0 24.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 CDI75432.1 - 0.37 9.7 13.7 0.47 9.4 13.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hydin_ADK PF17213.3 CDI75432.1 - 0.62 10.3 19.7 0.8 9.9 19.7 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF2828 PF11443.8 CDI75432.1 - 0.74 7.8 20.2 0.99 7.4 20.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) FAM60A PF15396.6 CDI75432.1 - 0.77 9.7 18.5 0.96 9.4 18.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A MIIP PF15734.5 CDI75432.1 - 0.85 9.0 18.4 0.98 8.8 18.4 1.1 1 0 0 1 1 1 0 Migration and invasion-inhibitory CDC45 PF02724.14 CDI75432.1 - 1 7.6 23.5 1.2 7.3 23.5 1.1 1 0 0 1 1 1 0 CDC45-like protein CCSAP PF15748.5 CDI75432.1 - 1.4 9.0 28.5 1.8 8.7 28.5 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated AXIN1_TNKS_BD PF16646.5 CDI75432.1 - 1.4 9.9 19.0 0.27 12.2 6.3 2.2 2 0 0 2 2 2 0 Axin-1 tankyrase binding domain Lin-8 PF03353.15 CDI75432.1 - 1.5 8.3 27.0 1.8 8.1 27.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CobT PF06213.12 CDI75432.1 - 1.9 7.8 37.4 0.33 10.3 10.9 2.0 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT PA26 PF04636.13 CDI75432.1 - 2.4 7.0 18.2 2.7 6.8 18.2 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PAT1 PF09770.9 CDI75432.1 - 2.6 6.2 37.5 2.8 6.1 37.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4551 PF15087.6 CDI75432.1 - 2.8 6.6 18.2 3.1 6.5 18.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DRY_EERY PF09750.9 CDI75432.1 - 3.4 7.9 21.1 5.2 7.3 21.1 1.3 1 0 0 1 1 1 0 Alternative splicing regulator SLC12 PF03522.15 CDI75432.1 - 3.9 6.4 26.9 4.5 6.2 26.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI75432.1 - 4.6 5.2 28.1 5.3 5.0 28.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MRC1 PF09444.10 CDI75432.1 - 4.9 7.6 25.0 6.9 7.2 25.0 1.2 1 0 0 1 1 1 0 MRC1-like domain LAP1C PF05609.12 CDI75432.1 - 5.1 6.1 23.5 5.6 5.9 23.5 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF3327 PF11806.8 CDI75432.1 - 6.3 7.5 16.3 1.4 9.7 3.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3327) Hamartin PF04388.12 CDI75432.1 - 7.9 5.0 21.9 8.4 4.9 21.9 1.0 1 0 0 1 1 1 0 Hamartin protein MAJIN PF15077.6 CDI75432.1 - 9.7 5.9 20.6 12 5.7 20.6 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Aminotran_5 PF00266.19 CDI75435.1 - 2.9e-19 69.3 0.1 5e-19 68.5 0.1 1.5 1 0 0 1 1 1 1 Aminotransferase class-V RskA PF10099.9 CDI75435.1 - 0.00091 19.6 26.9 0.01 16.1 11.2 2.9 1 1 1 2 2 2 1 Anti-sigma-K factor rskA RPA43_OB PF17875.1 CDI75435.1 - 0.02 15.5 1.0 12 6.6 2.5 2.5 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Roughex PF06020.11 CDI75435.1 - 0.029 13.5 4.8 0.07 12.2 4.8 1.6 1 0 0 1 1 1 0 Drosophila roughex protein Spt20 PF12090.8 CDI75435.1 - 0.2 11.2 28.4 0.56 9.8 19.3 2.2 2 0 0 2 2 2 0 Spt20 family EIIBC-GUT_N PF03612.14 CDI75435.1 - 1.1 8.9 4.1 2.7 7.7 4.1 1.6 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus MCU PF04678.13 CDI75435.1 - 6.8 6.8 8.4 4.3 7.4 3.9 2.3 2 0 0 2 2 2 0 Mitochondrial calcium uniporter SR-25 PF10500.9 CDI75436.1 - 0.0027 17.4 13.3 0.0032 17.1 13.3 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4048 PF13257.6 CDI75436.1 - 0.08 12.8 18.5 0.09 12.6 18.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4048) Spore_coat_CotO PF14153.6 CDI75436.1 - 0.24 11.3 20.2 0.25 11.2 20.2 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Pex14_N PF04695.13 CDI75436.1 - 0.53 10.9 27.4 0.72 10.5 27.4 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SprA-related PF12118.8 CDI75436.1 - 0.9 8.6 27.8 1.1 8.4 27.8 1.0 1 0 0 1 1 1 0 SprA-related family CCSAP PF15748.5 CDI75436.1 - 1 9.5 20.7 1.2 9.2 20.7 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated STAC2_u1 PF16664.5 CDI75436.1 - 1.2 9.6 15.4 1.4 9.4 15.4 1.1 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 RR_TM4-6 PF06459.12 CDI75436.1 - 1.3 8.8 15.5 1.4 8.6 15.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TCP PF03634.13 CDI75436.1 - 1.4 9.4 18.2 1.6 9.3 18.2 1.1 1 0 0 1 1 1 0 TCP family transcription factor TFIIA PF03153.13 CDI75436.1 - 2.2 8.2 40.2 2.4 8.1 40.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pal1 PF08316.11 CDI75436.1 - 2.3 9.0 9.5 2.8 8.7 9.5 1.2 1 0 0 1 1 1 0 Pal1 cell morphology protein PAT1 PF09770.9 CDI75436.1 - 2.5 6.2 25.0 2.6 6.2 25.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Activator_LAG-3 PF11498.8 CDI75436.1 - 2.6 6.9 47.0 2.7 6.9 47.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Velvet PF11754.8 CDI75436.1 - 3 7.7 21.3 3.3 7.6 21.3 1.0 1 0 0 1 1 1 0 Velvet factor DUF4407 PF14362.6 CDI75436.1 - 3.3 7.0 17.0 3.7 6.8 17.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MCU PF04678.13 CDI75436.1 - 3.6 7.7 10.4 4 7.5 10.4 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter CENP-H PF05837.12 CDI75436.1 - 3.8 8.0 19.7 4.3 7.8 19.7 1.1 1 0 0 1 1 1 0 Centromere protein H (CENP-H) SpoIIP PF07454.11 CDI75436.1 - 4.6 6.6 16.8 6 6.3 16.8 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Peptidase_S64 PF08192.11 CDI75436.1 - 4.9 5.5 16.1 5.3 5.4 16.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 FAM60A PF15396.6 CDI75436.1 - 5.1 7.0 15.1 6.4 6.7 15.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF4471 PF14740.6 CDI75436.1 - 5.3 6.2 13.2 5.8 6.0 13.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) MMR1 PF08505.10 CDI75436.1 - 5.8 7.1 25.8 6.7 6.9 25.8 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Presenilin PF01080.17 CDI75436.1 - 6.1 5.5 24.0 6.9 5.3 24.0 1.0 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 CDI75436.1 - 6.9 5.5 13.1 7 5.5 13.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CobT PF06213.12 CDI75436.1 - 7.8 5.8 21.7 10 5.4 21.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MTBP_C PF14920.6 CDI75436.1 - 8.6 6.0 19.5 9.4 5.9 19.5 1.0 1 0 0 1 1 1 0 MDM2-binding CCDC53 PF10152.9 CDI75436.1 - 9.8 6.6 18.6 13 6.2 18.6 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex PT PF04886.12 CDI75437.1 - 2.6 7.7 28.8 0.76 9.4 8.8 4.6 3 1 1 4 4 4 0 PT repeat Spt20 PF12090.8 CDI75437.1 - 2.8 7.5 21.2 3.6 7.1 21.2 1.0 1 0 0 1 1 1 0 Spt20 family K_channel_TID PF07941.11 CDI75438.1 - 0.0018 18.7 9.9 0.0018 18.7 9.9 15.6 9 6 2 11 11 11 1 Potassium channel Kv1.4 tandem inactivation domain Cwf_Cwc_15 PF04889.12 CDI75438.1 - 0.0098 15.6 9.9 0.0098 15.6 9.9 6.6 3 2 1 6 6 6 2 Cwf15/Cwc15 cell cycle control protein Btz PF09405.10 CDI75440.1 - 1.7e-11 44.5 1.0 1.7e-11 44.5 1.0 1.8 2 0 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding TFIIA PF03153.13 CDI75441.1 - 0.00033 20.8 23.9 0.00058 20.0 23.9 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI75441.1 - 0.63 9.6 43.0 0.03 14.0 27.0 2.4 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein SOBP PF15279.6 CDI75441.1 - 0.86 10.2 20.5 2.8 8.5 13.3 2.1 2 0 0 2 2 2 0 Sine oculis-binding protein RR_TM4-6 PF06459.12 CDI75441.1 - 1.6 8.5 18.4 0.4 10.5 14.1 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 EcsB PF05975.12 CDI75442.1 - 0.00056 18.9 5.5 0.001 18.0 5.5 1.5 1 0 0 1 1 1 1 Bacterial ABC transporter protein EcsB SpoIIIAH PF12685.7 CDI75442.1 - 0.016 15.1 39.5 0.022 14.6 39.5 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein CobD_Cbib PF03186.13 CDI75442.1 - 0.17 11.1 0.4 0.38 9.9 0.4 1.6 1 0 0 1 1 1 0 CobD/Cbib protein CitMHS PF03600.16 CDI75442.1 - 0.2 10.8 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 Citrate transporter Dicty_REP PF05086.12 CDI75442.1 - 0.47 8.4 30.6 0.64 7.9 30.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein LptF_LptG PF03739.14 CDI75442.1 - 1.5 7.6 20.8 1.9 7.3 20.8 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Wzy_C PF04932.15 CDI75442.1 - 4.1 7.0 7.3 11 5.7 7.0 2.1 1 1 0 1 1 1 0 O-Antigen ligase Sarcoglycan_1 PF04790.13 CDI75442.1 - 9.8 5.4 30.5 17 4.7 30.5 1.5 1 1 0 1 1 1 0 Sarcoglycan complex subunit protein RXT2_N PF08595.11 CDI75443.1 - 0.027 14.5 9.1 0.026 14.6 9.1 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 CDI75443.1 - 0.064 12.6 16.4 0.064 12.6 16.4 1.0 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 CDI75443.1 - 0.11 12.3 11.0 0.11 12.3 11.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 CDI75443.1 - 0.11 10.5 21.8 0.13 10.4 21.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi HA2 PF04408.23 CDI75443.1 - 0.13 12.5 1.8 0.14 12.5 1.8 1.1 1 0 0 1 1 1 0 Helicase associated domain (HA2) Paf1 PF03985.13 CDI75443.1 - 0.19 10.7 17.1 0.18 10.7 17.1 1.0 1 0 0 1 1 1 0 Paf1 TRM13 PF05206.14 CDI75443.1 - 0.2 11.1 3.1 0.2 11.1 3.1 1.0 1 0 0 1 1 1 0 Methyltransferase TRM13 SDA1 PF05285.12 CDI75443.1 - 0.24 10.8 16.5 0.23 10.9 16.5 1.0 1 0 0 1 1 1 0 SDA1 Laps PF10169.9 CDI75443.1 - 0.29 11.7 6.7 0.28 11.8 6.7 1.1 1 0 0 1 1 1 0 Learning-associated protein CDC45 PF02724.14 CDI75443.1 - 0.29 9.4 13.9 0.27 9.5 13.9 1.0 1 0 0 1 1 1 0 CDC45-like protein HSP90 PF00183.18 CDI75443.1 - 0.29 10.0 13.9 0.28 10.0 13.9 1.0 1 0 0 1 1 1 0 Hsp90 protein EIIBC-GUT_N PF03612.14 CDI75443.1 - 0.3 10.8 4.2 0.3 10.8 4.2 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Nop14 PF04147.12 CDI75443.1 - 0.31 9.2 17.6 0.3 9.3 17.6 1.0 1 0 0 1 1 1 0 Nop14-like family Usp PF00582.26 CDI75443.1 - 0.32 11.5 5.6 0.33 11.5 5.6 1.1 1 0 0 1 1 1 0 Universal stress protein family RPN2_C PF18004.1 CDI75443.1 - 0.34 10.8 11.0 0.34 10.8 11.0 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Sigma70_ner PF04546.13 CDI75443.1 - 0.36 10.7 16.1 0.41 10.5 16.1 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region CobT PF06213.12 CDI75443.1 - 0.36 10.2 15.3 0.4 10.0 15.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 CDI75443.1 - 0.36 11.0 6.0 0.34 11.1 6.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal TFB6 PF17110.5 CDI75443.1 - 0.46 10.2 8.5 0.44 10.3 8.5 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF3464 PF11947.8 CDI75443.1 - 0.5 10.1 3.5 0.55 10.0 3.5 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 AIF_C PF14721.6 CDI75443.1 - 0.52 10.7 3.4 0.61 10.4 3.4 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Eaf7 PF07904.13 CDI75443.1 - 0.56 10.6 8.1 0.62 10.5 8.1 1.1 1 0 0 1 1 1 0 Chromatin modification-related protein EAF7 RPA43_OB PF17875.1 CDI75443.1 - 0.6 10.7 7.2 0.65 10.6 7.2 1.1 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I DUF4746 PF15928.5 CDI75443.1 - 0.6 9.5 16.7 0.58 9.5 16.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Nop53 PF07767.11 CDI75443.1 - 0.62 9.4 15.9 0.59 9.5 15.9 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Folate_carrier PF01770.18 CDI75443.1 - 0.63 8.7 2.2 0.63 8.7 2.2 1.0 1 0 0 1 1 1 0 Reduced folate carrier RNA_pol_Rpc4 PF05132.14 CDI75443.1 - 0.75 10.2 3.8 0.8 10.1 3.8 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 TRAP_alpha PF03896.16 CDI75443.1 - 0.81 8.8 10.6 0.77 8.9 10.6 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RabGAP-TBC PF00566.18 CDI75443.1 - 0.87 9.2 2.7 1.1 8.9 2.7 1.0 1 0 0 1 1 1 0 Rab-GTPase-TBC domain GNAT_acetyltr_2 PF13718.6 CDI75443.1 - 0.87 8.9 3.8 0.89 8.9 3.8 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 TFIIF_alpha PF05793.12 CDI75443.1 - 0.92 8.0 17.0 0.89 8.1 17.0 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Connexin PF00029.19 CDI75443.1 - 0.94 9.2 5.0 0.9 9.3 5.0 1.1 1 0 0 1 1 1 0 Connexin Radial_spoke PF04712.12 CDI75443.1 - 1.1 8.1 19.5 1.5 7.7 19.5 1.3 1 0 0 1 1 1 0 Radial spokehead-like protein Vfa1 PF08432.10 CDI75443.1 - 1.1 9.5 10.5 1.2 9.5 10.5 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PTPRCAP PF15713.5 CDI75443.1 - 1.1 9.5 16.6 1.2 9.4 16.6 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF4820 PF16091.5 CDI75443.1 - 1.5 8.2 7.9 1.5 8.1 7.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) ORC_WH_C PF18137.1 CDI75443.1 - 1.6 8.8 8.6 1.8 8.6 8.6 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Presenilin PF01080.17 CDI75443.1 - 1.8 7.2 4.6 1.7 7.3 4.6 1.0 1 0 0 1 1 1 0 Presenilin PI3K_1B_p101 PF10486.9 CDI75443.1 - 1.8 6.2 9.3 1.8 6.3 9.3 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF913 PF06025.12 CDI75443.1 - 1.9 7.4 6.1 1.8 7.4 6.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RNA_pol_3_Rpc31 PF11705.8 CDI75443.1 - 1.9 8.7 23.3 2 8.6 23.3 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CAF1A PF12253.8 CDI75443.1 - 2.2 8.5 20.4 2.5 8.3 20.4 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A PPP4R2 PF09184.11 CDI75443.1 - 2.6 7.5 19.7 2.6 7.6 19.7 1.0 1 0 0 1 1 1 0 PPP4R2 MAP17 PF15807.5 CDI75443.1 - 3.7 7.8 7.2 3.8 7.8 7.2 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SspB PF04386.13 CDI75443.1 - 3.7 7.4 8.9 4.3 7.2 8.9 1.1 1 0 0 1 1 1 0 Stringent starvation protein B Auts2 PF15336.6 CDI75443.1 - 4.4 7.4 7.2 4.7 7.3 7.2 1.1 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein RAB3GAP2_C PF14656.6 CDI75443.1 - 4.4 5.4 6.0 4.3 5.4 6.0 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus V_ATPase_I PF01496.19 CDI75443.1 - 5.2 4.8 7.5 5.1 4.9 7.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TFIIA PF03153.13 CDI75443.1 - 6 6.7 13.8 5.8 6.8 13.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4637 PF15470.6 CDI75443.1 - 6.6 6.4 19.6 8 6.2 19.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Pes-10 PF07149.11 CDI75443.1 - 6.6 5.7 16.2 7.1 5.6 16.2 1.0 1 0 0 1 1 1 0 Pes-10 RRN3 PF05327.11 CDI75443.1 - 7.2 5.0 13.6 7.6 4.9 13.6 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Zip PF02535.22 CDI75443.1 - 7.7 5.6 5.0 6.9 5.8 5.0 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Sporozoite_P67 PF05642.11 CDI75443.1 - 8.2 4.4 10.6 8.6 4.3 10.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2457 PF10446.9 CDI75443.1 - 8.2 5.4 23.6 8.9 5.3 23.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-T_N PF16171.5 CDI75443.1 - 8.9 5.1 8.3 9.1 5.1 8.3 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T N-terminus RskA PF10099.9 CDI75448.1 - 0.00019 21.8 15.1 0.011 16.0 14.5 2.8 1 1 0 1 1 1 1 Anti-sigma-K factor rskA Plasmodium_Vir PF05795.11 CDI75448.1 - 0.19 11.1 1.1 0.35 10.3 1.1 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SUIM_assoc PF16619.5 CDI75448.1 - 0.45 10.6 42.3 0.11 12.6 0.4 5.0 5 0 0 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 MAP70 PF07058.11 CDI75448.1 - 2 7.1 5.9 3.6 6.2 5.9 1.3 1 0 0 1 1 1 0 Microtubule-associated protein 70 TFIIA PF03153.13 CDI75448.1 - 2.1 8.2 31.5 39 4.1 31.8 2.2 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.19 CDI75448.1 - 5.3 7.7 10.0 17 6.1 10.0 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein HSP70 PF00012.20 CDI75449.1 - 9.2e-207 687.9 10.2 1e-206 687.7 10.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDI75449.1 - 1.2e-18 67.0 0.4 1.9e-18 66.4 0.4 1.2 1 0 0 1 1 1 1 MreB/Mbl protein Radial_spoke_3 PF06098.11 CDI75449.1 - 0.00057 19.3 0.8 0.0012 18.2 0.8 1.5 1 0 0 1 1 1 1 Radial spoke protein 3 DDR PF08841.10 CDI75449.1 - 0.007 15.4 0.2 1.6 7.7 0.1 2.4 2 0 0 2 2 2 2 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.16 CDI75449.1 - 0.0088 15.8 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Stathmin PF00836.19 CDI75449.1 - 0.026 14.5 1.2 0.066 13.2 1.2 1.6 1 0 0 1 1 1 0 Stathmin family SIKE PF05769.11 CDI75449.1 - 0.1 12.5 0.3 0.1 12.5 0.3 1.8 2 0 0 2 2 2 0 SIKE family DUF883 PF05957.13 CDI75449.1 - 6.6 7.4 7.8 4.7 7.9 2.2 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) AAA_23 PF13476.6 CDI75450.1 - 0.0039 17.7 2.7 0.0039 17.7 2.7 7.8 7 1 0 7 7 7 2 AAA domain Glyco_hydro_9 PF00759.19 CDI75451.1 - 0.24 10.8 9.3 0.24 10.8 9.3 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 PRP38_assoc PF12871.7 CDI75451.1 - 4.7 7.9 116.3 1.1 9.9 33.0 3.7 1 1 1 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term RskA PF10099.9 CDI75452.1 - 2.9 8.1 23.6 4.2 7.6 23.6 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Glyco_hydro_9 PF00759.19 CDI75452.1 - 3.9 6.8 16.3 4.4 6.6 16.3 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 Ribosomal_60s PF00428.19 CDI75453.1 - 0.00027 21.5 9.6 0.00027 21.5 9.6 8.5 4 1 4 8 8 8 1 60s Acidic ribosomal protein RskA PF10099.9 CDI75453.1 - 0.0018 18.6 34.0 0.008 16.5 22.9 5.9 1 1 4 5 5 5 2 Anti-sigma-K factor rskA DUF3824 PF12868.7 CDI75453.1 - 0.011 16.4 4.0 0.011 16.4 4.0 6.7 4 1 2 6 6 6 0 Domain of unknwon function (DUF3824) TFIIF_alpha PF05793.12 CDI75453.1 - 0.43 9.1 29.0 0.076 11.6 21.1 2.3 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) baeRF_family10 PF18854.1 CDI75454.1 - 0.065 13.5 5.5 0.073 13.3 5.5 1.1 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 GARP PF16731.5 CDI75454.1 - 0.15 11.7 19.6 0.18 11.5 19.6 1.0 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma BAF1_ABF1 PF04684.13 CDI75454.1 - 2.3 7.2 13.4 2.3 7.2 13.4 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor ATP11 PF06644.11 CDI75454.1 - 4.5 7.0 9.4 4.6 6.9 9.4 1.0 1 0 0 1 1 1 0 ATP11 protein TraV PF09676.10 CDI75454.1 - 5.7 7.9 9.7 6.9 7.7 9.7 1.1 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) TFIIA PF03153.13 CDI75455.1 - 0.0017 18.5 43.6 0.0017 18.5 43.6 3.5 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit DUF4820 PF16091.5 CDI75455.1 - 0.0037 16.7 0.2 0.0037 16.7 0.2 6.3 2 2 4 6 6 6 1 Domain of unknown function (DUF4820) Ribosomal_60s PF00428.19 CDI75455.1 - 0.0085 16.7 0.3 0.0085 16.7 0.3 6.8 3 2 0 3 3 3 1 60s Acidic ribosomal protein Polysacc_synt_3 PF13440.6 CDI75455.1 - 0.082 12.1 4.1 0.12 11.6 0.6 2.6 3 0 0 3 3 3 0 Polysaccharide biosynthesis protein Citrate_synt PF00285.21 CDI75457.1 - 5.3 6.0 9.2 7.2 5.6 9.2 1.2 1 0 0 1 1 1 0 Citrate synthase, C-terminal domain DUF5363 PF17320.2 CDI75458.1 - 0.013 15.3 0.0 7.3 6.6 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5363) VWA PF00092.28 CDI75458.1 - 0.015 15.6 0.0 26 5.0 0.0 3.3 2 1 1 3 3 3 0 von Willebrand factor type A domain VWA_CoxE PF05762.14 CDI75458.1 - 0.016 14.6 1.1 2.1 7.6 0.5 3.0 1 1 2 3 3 3 0 VWA domain containing CoxE-like protein AAA_5 PF07728.14 CDI75460.1 - 3.7e-13 49.7 0.0 8.4e-06 25.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 CDI75460.1 - 0.00016 21.7 0.0 0.0008 19.5 0.0 2.2 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain DUF815 PF05673.13 CDI75460.1 - 0.0081 15.3 0.3 0.051 12.7 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA PF00004.29 CDI75460.1 - 0.015 15.7 0.0 0.04 14.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.11 CDI75460.1 - 0.06 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AvrPtoB_bdg PF16847.5 CDI75460.1 - 0.1 13.1 0.0 43 4.7 0.0 3.2 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain TsaE PF02367.17 CDI75460.1 - 0.13 12.3 0.1 0.41 10.6 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 CDI75460.1 - 0.18 12.3 3.4 0.19 12.3 0.0 2.6 2 0 0 2 2 2 0 ABC transporter MCD_N PF17408.2 CDI75460.1 - 1.4 9.1 5.7 22 5.3 0.4 3.4 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase N-terminal domain AAA_5 PF07728.14 CDI75461.1 - 1.8e-13 50.6 0.0 1.6e-07 31.4 0.0 2.3 1 1 1 2 2 2 2 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 CDI75461.1 - 0.0048 17.0 0.0 0.66 10.1 0.0 2.3 2 0 0 2 2 2 2 Dynein heavy chain region D6 P-loop domain Exonuc_VII_L PF02601.15 CDI75462.1 - 0.00014 21.5 16.0 0.00014 21.5 16.0 10.4 1 1 4 7 7 7 1 Exonuclease VII, large subunit CDP-OH_P_transf PF01066.21 CDI75463.1 - 1.1e-07 32.5 2.0 1.1e-07 32.5 2.0 2.3 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase SR-25 PF10500.9 CDI75465.1 - 0.00048 19.8 25.0 0.00064 19.4 25.0 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI75465.1 - 0.14 12.2 55.6 0.16 11.9 55.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spem1 PF15670.5 CDI75465.1 - 0.19 11.3 25.9 0.22 11.0 25.9 1.0 1 0 0 1 1 1 0 Spermatid maturation protein 1 CCSAP PF15748.5 CDI75465.1 - 0.28 11.3 37.6 0.31 11.2 37.6 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Spc7_N PF15402.6 CDI75465.1 - 0.54 8.4 25.3 0.62 8.2 25.3 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Velvet PF11754.8 CDI75465.1 - 0.55 10.1 26.6 0.71 9.8 26.6 1.2 1 0 0 1 1 1 0 Velvet factor eIF-3_zeta PF05091.12 CDI75465.1 - 2.2 7.2 31.6 2.6 6.9 31.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Band_3_cyto PF07565.13 CDI75465.1 - 3.6 7.3 27.8 5.8 6.6 27.8 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain N6_N4_Mtase PF01555.18 CDI75465.1 - 4.1 7.0 9.7 4.3 7.0 9.7 1.1 1 0 0 1 1 1 0 DNA methylase DUF4746 PF15928.5 CDI75465.1 - 5.4 6.3 23.5 6.3 6.1 23.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SOBP PF15279.6 CDI75465.1 - 5.5 7.5 26.4 6.3 7.3 26.4 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Hamartin PF04388.12 CDI75465.1 - 6 5.4 29.8 6.6 5.3 29.8 1.0 1 0 0 1 1 1 0 Hamartin protein PPP1R26_N PF15740.5 CDI75465.1 - 6.9 5.2 35.2 8.1 5.0 35.2 1.0 1 0 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 26 N-terminus PPP4R2 PF09184.11 CDI75465.1 - 7.1 6.1 25.5 8.6 5.8 25.5 1.1 1 0 0 1 1 1 0 PPP4R2 NARP1 PF12569.8 CDI75465.1 - 8.2 5.2 26.8 9.4 5.0 26.8 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF308 PF03729.13 CDI75466.1 - 0.00063 20.0 0.5 0.0015 18.8 0.5 1.6 1 0 0 1 1 1 1 Short repeat of unknown function (DUF308) Phage_holin_3_6 PF07332.11 CDI75466.1 - 0.0029 17.6 1.6 0.017 15.1 0.5 2.3 2 0 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III DUF3112 PF11309.8 CDI75466.1 - 0.034 13.6 2.9 0.067 12.6 2.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Auxin_canalis PF05703.11 CDI75466.1 - 0.067 13.1 5.8 0.099 12.6 5.8 1.3 1 0 0 1 1 1 0 Auxin canalisation DUF454 PF04304.13 CDI75466.1 - 0.26 11.3 5.5 0.21 11.6 3.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF454) SART-1 PF03343.13 CDI75466.1 - 0.29 9.6 11.7 0.4 9.2 11.7 1.2 1 0 0 1 1 1 0 SART-1 family DUF1418 PF07214.12 CDI75466.1 - 1.6 8.6 0.0 1.6 8.6 0.0 2.7 3 1 0 3 3 2 0 Protein of unknown function (DUF1418) THAP PF05485.12 CDI75466.1 - 2.7 9.0 9.4 0.28 12.1 2.8 2.4 3 0 0 3 3 2 0 THAP domain CLN3 PF02487.17 CDI75466.1 - 3.4 6.6 6.9 1 8.3 3.6 1.8 2 0 0 2 2 2 0 CLN3 protein PTPRCAP PF15713.5 CDI75466.1 - 6.1 7.1 16.5 3.4 7.9 9.2 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated CD20 PF04103.15 CDI75466.1 - 7.5 6.6 8.8 0.71 10.0 0.2 2.5 2 0 0 2 2 2 0 CD20-like family RR_TM4-6 PF06459.12 CDI75466.1 - 9.3 6.0 12.4 4.8 6.9 9.9 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 STAC2_u1 PF16664.5 CDI75466.1 - 9.5 6.7 11.6 6.1 7.3 9.1 1.9 2 0 0 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 SR-25 PF10500.9 CDI75467.1 - 0.0076 15.9 19.1 0.0076 15.9 19.1 8.0 5 4 1 7 7 7 1 Nuclear RNA-splicing-associated protein Baculo_PP31 PF05311.11 CDI75468.1 - 0.045 13.2 2.2 0.077 12.5 2.2 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) MDM10 PF12519.8 CDI75468.1 - 0.23 10.3 3.3 0.36 9.7 3.3 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF4834 PF16118.5 CDI75468.1 - 0.6 11.1 6.3 0.12 13.3 2.2 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DUF2722 PF10846.8 CDI75468.1 - 0.7 8.8 17.4 1.3 7.8 17.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI75468.1 - 1.6 8.6 34.0 1.9 8.4 34.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EIIBC-GUT_N PF03612.14 CDI75470.1 - 0.01 15.6 1.4 0.01 15.6 1.4 6.5 6 1 0 6 6 6 0 Sorbitol phosphotransferase enzyme II N-terminus RskA PF10099.9 CDI75470.1 - 0.048 13.9 0.0 0.024 15.0 9.1 10.1 3 2 4 7 7 7 0 Anti-sigma-K factor rskA Shadoo PF14999.6 CDI75471.1 - 0.0044 17.1 0.6 0.0044 17.1 0.6 6.0 1 1 5 6 6 6 1 Shadow of prion protein, neuroprotective Parvo_coat PF00740.18 CDI75471.1 - 1.1 7.8 7.7 1.7 7.2 7.7 1.2 1 0 0 1 1 1 0 Parvovirus coat protein VP2 PBP1_TM PF14812.6 CDI75471.1 - 2.2 8.7 7.5 19 5.7 1.8 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UPF0139 PF03669.13 CDI75472.1 - 0.16 11.9 0.9 0.39 10.6 0.9 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0139) RICTOR_N PF14664.6 CDI75472.1 - 0.17 10.8 4.9 0.2 10.6 4.9 1.2 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term Presenilin PF01080.17 CDI75472.1 - 0.24 10.1 11.1 0.26 10.0 11.1 1.1 1 0 0 1 1 1 0 Presenilin SfLAP PF11139.8 CDI75472.1 - 0.26 10.7 0.0 0.31 10.4 0.0 1.1 1 0 0 1 1 1 0 Sap, sulfolipid-1-addressing protein Folliculin PF11704.8 CDI75472.1 - 1 9.2 7.6 1.1 9.1 7.6 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF2828 PF11443.8 CDI75472.1 - 1.1 7.3 9.0 1.2 7.2 9.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) COG4 PF08318.12 CDI75472.1 - 1.1 8.3 11.5 2.2 7.3 11.5 1.5 1 1 0 1 1 1 0 COG4 transport protein NUDIX_2 PF13869.6 CDI75472.1 - 1.2 8.7 6.7 1.3 8.6 6.7 1.0 1 0 0 1 1 1 0 Nucleotide hydrolase DUF3402 PF11882.8 CDI75472.1 - 1.3 8.1 13.3 1.4 8.0 13.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) Ndc1_Nup PF09531.10 CDI75472.1 - 1.3 7.6 9.5 1.5 7.5 9.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CrgA PF06781.12 CDI75472.1 - 1.3 9.1 5.0 0.52 10.4 1.2 1.9 2 0 0 2 2 2 0 Cell division protein CrgA CSG2 PF16965.5 CDI75472.1 - 1.6 7.6 3.6 1.8 7.4 3.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Virul_fac_BrkB PF03631.15 CDI75472.1 - 2.6 7.6 3.9 0.46 10.0 0.3 1.5 1 1 1 2 2 2 0 Virulence factor BrkB MDM10 PF12519.8 CDI75472.1 - 2.8 6.7 7.7 3.1 6.6 7.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CDC14 PF08045.11 CDI75472.1 - 3.6 6.6 13.3 4.9 6.2 13.2 1.3 1 1 0 1 1 1 0 Cell division control protein 14, SIN component Neur_chan_memb PF02932.16 CDI75472.1 - 3.9 7.5 8.4 5.1 7.1 8.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI75472.1 - 4 6.2 7.2 4.5 6.0 7.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter EIIBC-GUT_N PF03612.14 CDI75472.1 - 4.5 7.0 12.0 5 6.8 6.5 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Peptidase_S49_N PF08496.10 CDI75472.1 - 4.6 7.3 11.7 2.2 8.3 6.3 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Orf78 PF06024.12 CDI75472.1 - 4.9 7.5 11.9 0.46 10.8 4.1 2.0 1 1 1 2 2 2 0 Orf78 (ac78) Sin_N PF04801.13 CDI75472.1 - 5.1 6.2 21.0 6.4 5.9 21.0 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region ATAD4 PF15321.6 CDI75472.1 - 5.9 8.3 10.1 34 5.9 0.2 2.0 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 DUF3043 PF11241.8 CDI75472.1 - 6.6 6.7 9.5 8.3 6.4 3.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) FlaG PF03646.15 CDI75472.1 - 7.9 6.7 24.9 2.1 8.6 12.1 2.1 2 0 0 2 2 2 0 FlaG protein dsDNA_bind PF01984.20 CDI75472.1 - 8.1 6.8 36.0 3.5 7.9 7.0 2.1 2 0 0 2 2 2 0 Double-stranded DNA-binding domain EIF4E-T PF10477.9 CDI75472.1 - 8.9 5.0 20.9 11 4.6 20.9 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E CLN3 PF02487.17 CDI75472.1 - 8.9 5.2 8.1 12 4.9 8.1 1.2 1 0 0 1 1 1 0 CLN3 protein O-antigen_lig PF13425.6 CDI75472.1 - 9.9 4.8 7.7 11 4.7 7.7 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Shisa PF13908.6 CDI75473.1 - 9 6.5 7.3 12 6.1 7.3 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator PIH1_CS PF18201.1 CDI75474.1 - 4.2e-07 30.3 0.1 8e-07 29.4 0.1 1.5 1 0 0 1 1 1 1 PIH1 CS-like domain Tmemb_9 PF05434.11 CDI75475.1 - 0.00014 21.7 1.5 0.0013 18.7 0.0 2.3 2 0 0 2 2 2 1 TMEM9 Spt20 PF12090.8 CDI75475.1 - 0.0015 18.2 28.6 0.09 12.4 4.7 2.2 2 0 0 2 2 2 2 Spt20 family Presenilin PF01080.17 CDI75475.1 - 0.16 10.7 8.2 1.5 7.5 4.9 2.2 2 0 0 2 2 2 0 Presenilin DUF4834 PF16118.5 CDI75475.1 - 2.2 9.3 17.7 0.15 13.0 0.7 3.0 2 2 0 2 2 2 0 Domain of unknown function (DUF4834) EPL1 PF10513.9 CDI75475.1 - 2.3 8.6 9.4 8.5 6.7 4.2 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF1230 PF06799.11 CDI75475.1 - 2.3 8.3 5.2 0.98 9.5 2.0 2.2 2 1 0 2 2 2 0 Conserved in the green lineage and diatoms 27 MMR1 PF08505.10 CDI75475.1 - 3.3 7.9 12.0 1.9 8.7 5.7 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein DUF2722 PF10846.8 CDI75476.1 - 0.0019 17.2 1.8 0.0019 17.2 1.8 10.8 7 3 3 10 10 10 2 Protein of unknown function (DUF2722) RRM_1 PF00076.22 CDI75477.1 - 3.5e-22 78.0 0.0 8e-16 57.6 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDI75477.1 - 0.0017 18.2 0.0 18 5.3 0.0 3.7 3 1 0 3 3 3 3 Occluded RNA-recognition motif Mito_fiss_reg PF05308.11 CDI75477.1 - 4.2 7.4 6.7 8.9 6.3 6.7 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator RVT_1 PF00078.27 CDI75479.1 - 1.1e-13 51.2 0.1 1.9e-13 50.5 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Chromo PF00385.24 CDI75479.1 - 2.3e-11 43.4 0.0 4.8e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RT_RNaseH PF17917.1 CDI75479.1 - 8.3e-11 42.1 0.0 1.6e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDI75479.1 - 0.035 14.1 0.0 0.082 13.0 0.0 1.6 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase PRIMA1 PF16101.5 CDI75479.1 - 1.6 8.8 8.0 3.5 7.7 8.0 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Lipl32 PF12103.8 CDI75480.1 - 0.074 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order DUF111 PF01969.17 CDI75481.1 - 0.023 13.8 0.0 0.024 13.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function DUF111 Fungal_trans PF04082.18 CDI75484.1 - 0.0049 15.9 1.5 1.2 8.1 0.0 2.7 3 0 0 3 3 3 2 Fungal specific transcription factor domain DC_STAMP PF07782.13 CDI75484.1 - 0.08 12.8 0.2 0.26 11.1 0.2 1.9 1 0 0 1 1 1 0 DC-STAMP-like protein MMM1 PF10296.9 CDI75484.1 - 0.49 9.4 0.0 0.49 9.4 0.0 3.0 3 1 1 4 4 4 0 Maintenance of mitochondrial morphology protein 1 Spt20 PF12090.8 CDI75484.1 - 5.4 6.6 83.4 0.15 11.7 15.6 4.3 4 0 0 4 4 4 0 Spt20 family HSP70 PF00012.20 CDI75486.1 - 1e-170 568.9 14.6 1.2e-125 420.0 1.8 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 CDI75486.1 - 3e-12 46.0 2.1 2.8e-10 39.6 0.1 2.5 3 0 0 3 3 3 2 MreB/Mbl protein Hydantoinase_A PF01968.18 CDI75486.1 - 0.0025 17.1 0.6 0.0076 15.5 0.6 1.8 1 1 0 1 1 1 1 Hydantoinase/oxoprolinase EcsC PF12787.7 CDI75486.1 - 0.0056 16.4 0.6 0.0099 15.6 0.6 1.3 1 0 0 1 1 1 1 EcsC protein family Hat1_N PF10394.9 CDI75486.1 - 0.013 15.7 0.2 0.035 14.3 0.2 1.7 1 0 0 1 1 1 0 Histone acetyl transferase HAT1 N-terminus Herpes_UL25 PF01499.16 CDI75486.1 - 0.045 12.3 0.2 0.09 11.3 0.2 1.5 1 1 0 1 1 1 0 Herpesvirus UL25 family FtsA PF14450.6 CDI75486.1 - 2.8 8.4 6.7 22 5.5 0.4 3.1 3 1 0 3 3 3 0 Cell division protein FtsA FAM222A PF15258.6 CDI75487.1 - 0.0048 16.1 15.1 0.0048 16.1 15.1 6.1 3 1 2 6 6 6 1 Protein family of FAM222A Conotoxin PF02950.17 CDI75487.1 - 0.013 16.5 1.1 0.013 16.5 1.1 9.3 9 3 1 11 11 11 0 Conotoxin PAP2 PF01569.21 CDI75487.1 - 0.61 9.8 5.7 1.7 8.4 0.0 3.8 5 0 0 5 5 5 0 PAP2 superfamily GRP PF07172.11 CDI75487.1 - 1.9 9.3 0.0 1.9 9.3 0.0 6.4 7 1 0 7 7 7 0 Glycine rich protein family Pro-rich PF15240.6 CDI75489.1 - 0.3 11.3 13.3 0.61 10.3 13.3 1.4 1 0 0 1 1 1 0 Proline-rich Bud13 PF09736.9 CDI75490.1 - 4.6e-39 134.1 6.0 4.6e-39 134.1 6.0 2.7 3 0 0 3 3 3 1 Pre-mRNA-splicing factor of RES complex AAA PF00004.29 CDI75491.1 - 6.7e-38 130.1 0.0 3.2e-36 124.7 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI75491.1 - 5e-08 32.6 0.1 1.1e-07 31.6 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CDI75491.1 - 6.3e-07 29.9 1.5 0.00079 19.9 0.2 3.4 1 1 3 4 4 4 2 AAA ATPase domain AAA_5 PF07728.14 CDI75491.1 - 0.00079 19.4 0.2 0.0047 16.9 0.1 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDI75491.1 - 0.0017 18.6 0.1 0.2 11.9 0.1 3.0 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 CDI75491.1 - 0.0021 18.2 0.0 0.0061 16.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CDI75491.1 - 0.005 16.4 0.0 0.013 15.0 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 CDI75491.1 - 0.013 16.0 0.0 0.32 11.6 0.0 2.5 2 1 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 CDI75491.1 - 0.014 15.1 0.2 0.04 13.6 0.1 1.7 2 0 0 2 2 2 0 Cytidylate kinase Mg_chelatase PF01078.21 CDI75491.1 - 0.036 13.4 0.0 0.092 12.1 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 CDI75491.1 - 0.048 13.4 0.0 0.16 11.7 0.0 1.9 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 CDI75491.1 - 0.052 13.3 0.0 0.098 12.4 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.13 CDI75491.1 - 0.056 12.6 0.0 0.38 9.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PhoH PF02562.16 CDI75491.1 - 0.063 12.7 0.0 0.063 12.7 0.0 1.6 2 0 0 2 2 1 0 PhoH-like protein TIP49 PF06068.13 CDI75491.1 - 0.063 12.5 1.3 0.11 11.7 0.1 1.9 2 1 0 2 2 2 0 TIP49 P-loop domain Sigma54_activat PF00158.26 CDI75491.1 - 0.09 12.5 0.0 0.33 10.7 0.0 1.9 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 CDI75491.1 - 0.12 12.3 0.1 0.49 10.3 0.1 2.1 1 1 1 2 2 2 0 NACHT domain ABC_tran PF00005.27 CDI75491.1 - 0.12 12.9 0.1 0.31 11.5 0.1 1.7 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 CDI75491.1 - 0.34 10.6 0.1 0.34 10.6 0.1 1.9 2 0 0 2 2 1 0 AAA domain RRM_1 PF00076.22 CDI75493.1 - 2.8e-36 123.2 0.1 7.7e-17 60.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDI75493.1 - 7.6e-06 25.8 0.0 0.013 15.5 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 CDI75493.1 - 5.6e-05 22.9 0.0 0.01 15.7 0.0 2.7 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_7 PF16367.5 CDI75493.1 - 0.012 15.8 0.0 0.73 10.0 0.0 3.1 2 1 0 2 2 2 0 RNA recognition motif DUF2207 PF09972.9 CDI75494.1 - 0.0003 19.7 0.0 0.0004 19.3 0.0 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF3450 PF11932.8 CDI75494.1 - 0.031 13.6 8.4 0.043 13.1 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) UPF0242 PF06785.11 CDI75494.1 - 0.047 13.8 9.4 0.077 13.1 9.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PIEZO PF15917.5 CDI75494.1 - 0.053 13.0 6.2 0.1 12.1 6.2 1.5 1 0 0 1 1 1 0 Piezo KAP_NTPase PF07693.14 CDI75494.1 - 0.08 12.2 0.9 0.11 11.7 0.9 1.2 1 0 0 1 1 1 0 KAP family P-loop domain DUF418 PF04235.12 CDI75494.1 - 0.12 12.3 1.3 0.12 12.3 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF418) Spore_III_AF PF09581.10 CDI75494.1 - 0.14 12.2 4.3 0.19 11.7 4.3 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) DUF3169 PF11368.8 CDI75494.1 - 0.25 10.8 0.4 0.74 9.3 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) FixQ PF05545.11 CDI75494.1 - 0.31 11.0 0.1 0.31 11.0 0.1 2.0 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DUF4328 PF14219.6 CDI75494.1 - 0.35 10.4 3.3 0.26 10.8 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4328) DUF1993 PF09351.10 CDI75494.1 - 0.42 10.7 3.9 0.78 9.9 3.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) DUF4404 PF14357.6 CDI75494.1 - 3.8 8.2 8.4 6.8 7.4 8.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) DUF4349 PF14257.6 CDI75494.1 - 5.7 6.3 9.0 12 5.3 9.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) G0-G1_switch_2 PF15103.6 CDI75494.1 - 7.6 7.0 7.7 69 3.9 6.8 2.7 2 1 0 2 2 2 0 G0/G1 switch protein 2 RskA PF10099.9 CDI75497.1 - 0.0048 17.2 8.9 0.0048 17.2 8.9 3.7 1 1 1 3 3 3 1 Anti-sigma-K factor rskA MDM10 PF12519.8 CDI75497.1 - 0.094 11.6 3.6 0.14 11.0 3.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SUIM_assoc PF16619.5 CDI75497.1 - 0.1 12.7 11.3 0.31 11.1 11.3 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 YflT PF11181.8 CDI75497.1 - 0.15 12.5 0.9 0.39 11.2 0.9 1.7 1 0 0 1 1 1 0 Heat induced stress protein YflT Salp15 PF12115.8 CDI75497.1 - 0.38 11.2 1.5 1.2 9.6 1.5 1.8 1 0 0 1 1 1 0 Salivary protein of 15kDa inhibits CD4+ T cell activation CDC13_N PF16853.5 CDI75497.1 - 0.94 9.0 5.2 1.4 8.4 5.2 1.2 1 0 0 1 1 1 0 Cell division control protein 13 N-terminus Ribosomal_60s PF00428.19 CDI75497.1 - 3.6 8.2 86.1 0.26 11.9 17.1 5.3 4 1 1 5 5 5 0 60s Acidic ribosomal protein LRR_9 PF14580.6 CDI75498.1 - 5.2e-05 22.8 0.0 8.3e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Leucine-rich repeat SDA1 PF05285.12 CDI75498.1 - 0.012 15.1 43.4 0.015 14.7 43.4 1.1 1 0 0 1 1 1 0 SDA1 Mpp10 PF04006.12 CDI75498.1 - 0.015 13.8 47.5 0.019 13.4 47.5 1.0 1 0 0 1 1 1 0 Mpp10 protein Suf PF05843.14 CDI75498.1 - 0.96 9.4 13.0 1.1 9.1 13.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4045 PF13254.6 CDI75498.1 - 1.8 8.2 19.8 2.2 7.8 19.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SLC12 PF03522.15 CDI75498.1 - 1.9 7.4 16.4 2.4 7.1 16.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 BUD22 PF09073.10 CDI75498.1 - 1.9 7.7 42.1 2.6 7.3 42.1 1.1 1 0 0 1 1 1 0 BUD22 Lin-8 PF03353.15 CDI75498.1 - 2.9 7.4 30.0 3.6 7.1 30.0 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Nop14 PF04147.12 CDI75498.1 - 6.6 4.8 48.5 10 4.2 48.5 1.2 1 0 0 1 1 1 0 Nop14-like family SseC PF04888.12 CDI75499.1 - 2.1e-05 24.3 19.9 2.4e-05 24.1 19.9 1.0 1 0 0 1 1 1 1 Secretion system effector C (SseC) like family PIP5K PF01504.18 CDI75499.1 - 2.1e-05 23.9 3.1 2.1e-05 23.9 3.1 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF2722 PF10846.8 CDI75499.1 - 3.9e-05 22.8 20.1 3.9e-05 22.8 20.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI75499.1 - 0.0016 18.1 31.7 0.002 17.8 31.7 1.2 1 0 0 1 1 1 1 Spt20 family Pex14_N PF04695.13 CDI75499.1 - 0.0027 18.4 16.4 0.0035 18.0 16.4 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2235 PF09994.9 CDI75499.1 - 0.0031 16.9 2.9 0.0033 16.8 2.9 1.0 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Peptidase_S49_N PF08496.10 CDI75499.1 - 0.012 15.7 8.9 0.014 15.5 8.9 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SpoIIP PF07454.11 CDI75499.1 - 0.012 15.0 6.2 0.01 15.3 6.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TFIIA PF03153.13 CDI75499.1 - 0.02 14.9 28.9 0.022 14.8 28.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sporozoite_P67 PF05642.11 CDI75499.1 - 0.027 12.6 0.8 0.037 12.1 0.8 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ATG2_CAD PF13329.6 CDI75499.1 - 0.1 12.3 2.6 0.13 12.0 2.6 1.2 1 0 0 1 1 1 0 Autophagy-related protein 2 CAD motif HD-ZIP_N PF04618.12 CDI75499.1 - 0.11 13.1 4.0 0.12 12.9 4.0 1.1 1 0 0 1 1 1 0 HD-ZIP protein N terminus DUF3292 PF11696.8 CDI75499.1 - 0.11 10.8 11.5 0.11 10.8 11.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) FAM176 PF14851.6 CDI75499.1 - 0.12 12.1 4.9 0.13 11.9 4.9 1.1 1 0 0 1 1 1 0 FAM176 family RR_TM4-6 PF06459.12 CDI75499.1 - 0.12 12.2 7.0 0.12 12.2 7.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MPM1 PF17234.2 CDI75499.1 - 0.17 12.1 9.7 0.19 12.0 9.7 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Gti1_Pac2 PF09729.9 CDI75499.1 - 0.18 11.8 6.1 0.19 11.8 6.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family EPL1 PF10513.9 CDI75499.1 - 0.21 11.9 11.5 0.25 11.7 11.5 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like MecA PF05389.12 CDI75499.1 - 0.23 11.0 10.1 0.24 11.0 10.1 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) BRF1 PF07741.13 CDI75499.1 - 0.25 11.7 11.7 0.33 11.3 11.7 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Tau95_N PF17682.1 CDI75499.1 - 0.26 11.5 7.0 0.35 11.1 7.0 1.2 1 0 0 1 1 1 0 Tau95 Triple barrel domain V_ATPase_I PF01496.19 CDI75499.1 - 0.27 9.1 9.5 0.25 9.2 9.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 CDI75499.1 - 0.35 10.6 6.4 0.36 10.5 6.4 1.1 1 0 0 1 1 1 0 Connexin Glt_symporter PF03616.14 CDI75499.1 - 0.36 9.5 4.2 0.42 9.3 4.2 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter FAM60A PF15396.6 CDI75499.1 - 0.37 10.8 5.9 0.35 10.8 5.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Suf PF05843.14 CDI75499.1 - 0.38 10.7 15.5 0.36 10.8 15.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 CDI75499.1 - 0.38 10.8 6.9 0.39 10.7 6.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TERB2 PF15101.6 CDI75499.1 - 0.42 10.6 15.9 0.43 10.6 15.9 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SLC12 PF03522.15 CDI75499.1 - 0.44 9.5 9.1 0.41 9.6 9.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 EIIBC-GUT_N PF03612.14 CDI75499.1 - 0.45 10.2 12.1 0.5 10.1 12.1 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF702 PF05142.12 CDI75499.1 - 0.51 10.8 12.3 0.62 10.5 12.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Ndc1_Nup PF09531.10 CDI75499.1 - 0.55 8.9 13.3 0.57 8.8 13.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3371 PF11851.8 CDI75499.1 - 0.56 11.3 13.7 0.61 11.2 13.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) DUF4770 PF15994.5 CDI75499.1 - 0.58 10.4 10.9 0.6 10.3 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Tim54 PF11711.8 CDI75499.1 - 0.58 8.9 8.0 0.56 8.9 8.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Fusion_gly PF00523.18 CDI75499.1 - 0.59 8.3 11.1 0.67 8.1 11.1 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 Band_3_cyto PF07565.13 CDI75499.1 - 0.6 9.9 8.8 0.57 9.9 8.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF3347 PF11827.8 CDI75499.1 - 0.63 10.2 12.6 0.7 10.1 12.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) CPSF100_C PF13299.6 CDI75499.1 - 0.64 10.2 11.5 0.79 9.9 11.5 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal BAT2_N PF07001.11 CDI75499.1 - 0.67 10.4 16.7 0.85 10.0 16.7 1.1 1 0 0 1 1 1 0 BAT2 N-terminus Orf78 PF06024.12 CDI75499.1 - 0.69 10.2 11.0 0.52 10.6 9.8 1.4 1 1 1 2 2 1 0 Orf78 (ac78) OATP PF03137.20 CDI75499.1 - 0.72 8.1 5.1 0.72 8.1 5.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CSG2 PF16965.5 CDI75499.1 - 0.75 8.7 4.5 0.88 8.5 4.5 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator eIF-3_zeta PF05091.12 CDI75499.1 - 0.81 8.6 14.8 0.76 8.7 14.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EOS1 PF12326.8 CDI75499.1 - 0.82 9.6 5.0 0.83 9.6 5.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein Med15 PF09606.10 CDI75499.1 - 0.92 8.1 29.9 0.94 8.1 29.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal ALMT PF11744.8 CDI75499.1 - 0.96 8.2 8.3 0.98 8.2 8.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 CDI75499.1 - 1.1 8.0 13.0 1.1 7.9 13.0 1.1 1 0 0 1 1 1 0 Presenilin DUF4647 PF15504.6 CDI75499.1 - 1.1 8.3 13.1 1.1 8.3 13.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) MDM31_MDM32 PF08118.11 CDI75499.1 - 1.1 7.9 7.5 1 7.9 7.5 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Peptidase_S64 PF08192.11 CDI75499.1 - 1.1 7.7 9.1 1.1 7.7 9.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 UPF0524 PF15823.5 CDI75499.1 - 1.2 8.5 5.7 1.1 8.6 5.7 1.2 1 0 0 1 1 1 0 UPF0524 of C3orf70 DUF4571 PF15137.6 CDI75499.1 - 1.2 8.8 5.5 1.2 8.7 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4571) WASH-7_C PF14746.6 CDI75499.1 - 1.3 8.6 11.4 1.4 8.5 11.4 1.2 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal Sec62 PF03839.16 CDI75499.1 - 1.4 8.3 9.0 1.4 8.3 9.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Ctr PF04145.15 CDI75499.1 - 1.5 9.4 5.4 1.6 9.4 5.4 1.2 1 0 0 1 1 1 0 Ctr copper transporter family UPF0560 PF10577.9 CDI75499.1 - 1.6 7.1 16.6 1.4 7.3 16.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 RIFIN PF02009.16 CDI75499.1 - 1.7 8.5 13.0 1.9 8.3 13.0 1.1 1 0 0 1 1 1 0 Rifin CLN3 PF02487.17 CDI75499.1 - 1.7 7.6 7.9 1.8 7.5 7.9 1.1 1 0 0 1 1 1 0 CLN3 protein WES_acyltransf PF03007.16 CDI75499.1 - 1.8 8.2 9.9 1.9 8.2 9.9 1.0 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain MDM10 PF12519.8 CDI75499.1 - 1.8 7.3 9.0 1.8 7.3 9.0 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 PAT1 PF09770.9 CDI75499.1 - 1.9 6.6 21.0 2 6.6 21.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_C58 PF03543.14 CDI75499.1 - 2 8.1 19.5 2.2 8.0 19.5 1.0 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen MMR1 PF08505.10 CDI75499.1 - 2.1 8.6 14.2 2.1 8.6 14.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein BAF1_ABF1 PF04684.13 CDI75499.1 - 2.4 7.1 14.7 2.8 6.9 14.7 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Plasmodium_Vir PF05795.11 CDI75499.1 - 3 7.2 5.7 3.1 7.1 5.7 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein GREB1 PF15782.5 CDI75499.1 - 3.5 4.6 12.1 3.6 4.6 12.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer USP8_interact PF08941.10 CDI75499.1 - 4 7.2 12.2 4.2 7.1 12.2 1.2 1 0 0 1 1 1 0 USP8 interacting PigN PF04987.14 CDI75499.1 - 5 5.9 7.2 5.6 5.7 7.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Hid1 PF12722.7 CDI75499.1 - 7.7 4.5 10.6 7.3 4.6 10.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein XRN_M PF17846.1 CDI75499.1 - 8.7 5.2 11.2 9.2 5.1 11.2 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Nop53 PF07767.11 CDI75499.1 - 9.6 5.5 20.3 9.7 5.5 20.3 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.14 CDI75500.1 - 0.0045 15.4 26.8 0.0054 15.1 26.8 1.0 1 0 0 1 1 1 1 CDC45-like protein LAP1C PF05609.12 CDI75500.1 - 0.22 10.6 36.5 0.25 10.4 36.5 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SAPS PF04499.15 CDI75500.1 - 0.41 9.4 25.1 0.51 9.1 25.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 CDI75500.1 - 3.9 6.1 48.6 4.6 5.9 48.6 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI75500.1 - 4.2 6.3 42.9 5 6.0 42.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF572 PF04502.13 CDI75500.1 - 5.5 6.5 31.7 6.8 6.2 31.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) RskA PF10099.9 CDI75502.1 - 4.4e-06 27.1 1.7 4.4e-06 27.1 1.7 21.4 4 4 6 12 12 12 2 Anti-sigma-K factor rskA AP2 PF00847.20 CDI75502.1 - 0.0075 16.5 0.8 0.0075 16.5 0.8 3.7 3 0 0 3 3 3 1 AP2 domain DUF3682 PF12446.8 CDI75502.1 - 0.0081 16.6 34.1 0.0081 16.6 34.1 32.0 12 7 15 28 28 28 1 Protein of unknown function (DUF3682) DUF3042 PF11240.8 CDI75504.1 - 0.038 14.0 0.3 0.16 12.0 0.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) DUF3916 PF13079.6 CDI75505.1 - 0.0013 18.6 0.0 0.0026 17.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3916) PEP-utilisers_N PF05524.13 CDI75505.1 - 7 6.8 7.0 5.3 7.2 2.3 2.6 1 1 2 3 3 3 0 PEP-utilising enzyme, N-terminal Glyco_transf_17 PF04724.13 CDI75506.1 - 8.1e-16 58.0 0.3 3e-15 56.1 0.3 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 17 Esterase PF00756.20 CDI75506.1 - 0.024 14.3 0.8 0.049 13.3 0.8 1.4 1 0 0 1 1 1 0 Putative esterase Fer4_24 PF18109.1 CDI75506.1 - 0.16 12.3 3.5 0.44 10.9 3.5 1.7 1 0 0 1 1 1 0 Ferredoxin I 4Fe-4S cluster domain DUF4551 PF15087.6 CDI75506.1 - 0.5 9.1 10.4 0.06 12.2 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4551) Epimerase PF01370.21 CDI75507.1 - 1.6e-43 149.0 0.0 2.2e-43 148.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDI75507.1 - 8.7e-07 28.6 0.0 1.3e-06 28.1 0.0 1.4 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CDI75507.1 - 0.0006 19.0 0.0 0.00092 18.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CDI75507.1 - 0.019 14.1 0.4 0.042 13.0 0.0 1.6 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein FAM76 PF16046.5 CDI75509.1 - 3.7 6.8 13.5 0.21 10.9 5.5 2.4 3 0 0 3 3 3 0 FAM76 protein Bacillus_HBL PF05791.11 CDI75509.1 - 9.3 6.0 15.0 0.081 12.8 4.9 2.4 3 0 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Consortin_C PF15281.6 CDI75510.1 - 8 6.5 9.9 8 6.5 0.6 3.4 3 0 0 3 3 3 0 Consortin C-terminus Activator_LAG-3 PF11498.8 CDI75512.1 - 7.7e-06 25.1 18.3 1.1e-05 24.6 18.3 1.2 1 0 0 1 1 1 1 Transcriptional activator LAG-3 TFIIA PF03153.13 CDI75512.1 - 1.6e-05 25.1 30.3 1.8e-05 24.9 30.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Rrn6 PF10214.9 CDI75512.1 - 0.01 14.4 27.3 0.014 13.9 27.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CobT PF06213.12 CDI75512.1 - 0.013 14.9 29.5 0.0086 15.5 25.0 2.4 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT VAPB_antitox PF02697.14 CDI75512.1 - 0.04 14.7 0.1 4.7 8.1 0.0 3.1 3 0 0 3 3 3 0 Putative antitoxin Asp-B-Hydro_N PF05279.11 CDI75512.1 - 0.62 10.1 17.0 1 9.3 17.0 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4746 PF15928.5 CDI75512.1 - 0.87 9.0 12.8 1.4 8.2 12.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PAT1 PF09770.9 CDI75512.1 - 1.4 7.1 24.3 1.7 6.8 24.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDC45 PF02724.14 CDI75512.1 - 1.5 7.0 24.0 0.41 8.9 18.3 2.0 2 0 0 2 2 2 0 CDC45-like protein ASD2 PF08687.11 CDI75512.1 - 1.8 8.0 21.3 10 5.6 18.8 2.1 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 DUF3492 PF11997.8 CDI75512.1 - 2.1 8.0 6.8 78 2.9 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF3492) Sin_N PF04801.13 CDI75512.1 - 2.5 7.2 23.6 4.1 6.5 23.6 1.3 1 0 0 1 1 1 0 Sin-like protein conserved region NST1 PF13945.6 CDI75512.1 - 4 7.5 25.5 0.54 10.3 18.3 2.3 2 0 0 2 2 2 0 Salt tolerance down-regulator SARAF PF06682.12 CDI75512.1 - 4.2 6.9 18.6 0.89 9.1 9.0 2.1 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3381 PF11861.8 CDI75512.1 - 4.3 7.1 19.0 8.7 6.1 19.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF3807 PF12720.7 CDI75512.1 - 4.8 7.4 28.6 7.4 6.8 25.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Utp14 PF04615.13 CDI75512.1 - 4.9 5.6 28.5 6.7 5.2 28.5 1.1 1 0 0 1 1 1 0 Utp14 protein Hamartin PF04388.12 CDI75512.1 - 6.7 5.2 25.4 9.8 4.7 25.4 1.2 1 0 0 1 1 1 0 Hamartin protein SR-25 PF10500.9 CDI75513.1 - 0.021 14.5 10.4 0.051 13.2 10.4 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Secretin_N_2 PF07655.13 CDI75513.1 - 0.71 10.5 14.3 1.8 9.1 14.3 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain RSRP PF17069.5 CDI75513.1 - 7.3 6.1 13.7 15 5.1 13.7 1.5 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 DUF572 PF04502.13 CDI75514.1 - 0.035 13.7 15.4 0.039 13.6 15.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SUIM_assoc PF16619.5 CDI75514.1 - 0.093 12.8 0.4 0.093 12.8 0.4 5.4 3 2 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Hid1 PF12722.7 CDI75514.1 - 3.5 5.6 21.7 4.1 5.4 21.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UCH PF00443.29 CDI75515.1 - 6.4e-22 78.3 0.0 2.2e-21 76.5 0.0 1.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Spt20 PF12090.8 CDI75515.1 - 7.3e-05 22.5 60.6 0.0037 16.9 19.8 3.4 3 0 0 3 3 3 3 Spt20 family EOS1 PF12326.8 CDI75515.1 - 0.0088 16.0 6.3 2.3 8.1 2.3 3.6 2 1 0 2 2 2 2 N-glycosylation protein TraT PF05818.12 CDI75515.1 - 0.031 14.0 0.2 0.031 14.0 0.2 5.4 5 1 0 5 5 5 0 Enterobacterial TraT complement resistance protein N6_N4_Mtase PF01555.18 CDI75515.1 - 0.15 11.8 2.1 4.8 6.8 0.5 2.3 2 0 0 2 2 2 0 DNA methylase eIF-3_zeta PF05091.12 CDI75515.1 - 1.5 7.7 32.0 0.029 13.4 10.3 2.8 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SR-25 PF10500.9 CDI75516.1 - 0.0016 18.1 27.8 0.0023 17.6 27.8 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein MDM1 PF15501.6 CDI75516.1 - 0.0019 17.4 20.9 0.0023 17.2 20.9 1.0 1 0 0 1 1 1 1 Nuclear protein MDM1 EMC3_TMCO1 PF01956.16 CDI75516.1 - 0.045 13.5 17.8 0.049 13.4 17.8 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like GBP_C PF02841.14 CDI75516.1 - 0.057 12.8 27.7 0.072 12.5 27.7 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Peptidase_C58 PF03543.14 CDI75516.1 - 0.063 13.0 19.3 0.077 12.7 19.3 1.2 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen TFIIA PF03153.13 CDI75516.1 - 0.072 13.1 47.4 0.079 12.9 47.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Miga PF10265.9 CDI75516.1 - 0.081 11.9 25.9 0.091 11.7 25.9 1.0 1 0 0 1 1 1 0 Mitoguardin Lin-8 PF03353.15 CDI75516.1 - 0.1 12.2 27.0 0.12 12.0 27.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist eIF-3_zeta PF05091.12 CDI75516.1 - 0.11 11.5 21.6 0.12 11.4 21.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TCRP1 PF14944.6 CDI75516.1 - 0.18 11.8 7.3 0.21 11.5 7.3 1.1 1 0 0 1 1 1 0 Tongue Cancer Chemotherapy Resistant Protein 1 MID_MedPIWI PF18296.1 CDI75516.1 - 0.25 11.1 21.7 0.28 10.9 21.7 1.1 1 0 0 1 1 1 0 MID domain of medPIWI Asp-B-Hydro_N PF05279.11 CDI75516.1 - 0.35 10.9 12.2 0.37 10.8 12.2 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Peptidase_S15 PF02129.18 CDI75516.1 - 0.44 10.1 10.8 0.51 9.9 10.8 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF4746 PF15928.5 CDI75516.1 - 0.5 9.7 9.8 0.54 9.6 9.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4175 PF13779.6 CDI75516.1 - 0.65 7.8 34.5 0.75 7.6 34.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) BORG_CEP PF14957.6 CDI75516.1 - 0.76 10.9 17.1 1 10.5 17.1 1.3 1 0 0 1 1 1 0 Cdc42 effector DUF4392 PF14336.6 CDI75516.1 - 1.1 8.7 6.9 1.3 8.4 6.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) FliP PF00813.20 CDI75516.1 - 1.2 9.0 8.4 1.3 8.8 8.4 1.3 1 0 0 1 1 1 0 FliP family DUF2052 PF09747.9 CDI75516.1 - 1.4 9.0 19.3 1.6 8.8 19.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CobT PF06213.12 CDI75516.1 - 1.9 7.8 25.9 2.2 7.6 25.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PIG-S PF10510.9 CDI75516.1 - 2 7.2 21.7 2.2 7.0 21.7 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein ABC2_membrane_2 PF12679.7 CDI75516.1 - 2.6 7.2 8.3 3.1 7.0 8.3 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein GREB1 PF15782.5 CDI75516.1 - 2.9 4.9 31.3 3.1 4.8 31.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PepSY_TM_like_2 PF16357.5 CDI75516.1 - 3.2 7.7 9.4 3.4 7.6 9.4 1.3 1 0 0 1 1 1 0 Putative PepSY_TM-like LCIB_C_CA PF18599.1 CDI75516.1 - 3.5 6.9 14.8 4.6 6.5 14.8 1.2 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases Cellulose_synt PF03552.14 CDI75516.1 - 3.6 6.0 13.7 4.1 5.8 13.7 1.0 1 0 0 1 1 1 0 Cellulose synthase Exonuc_VII_L PF02601.15 CDI75516.1 - 4.8 6.7 28.0 4.9 6.6 28.0 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ribosomal_60s PF00428.19 CDI75516.1 - 4.8 7.8 15.1 8.7 7.0 15.1 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein MAT1 PF06391.13 CDI75516.1 - 4.9 6.9 34.9 6.3 6.6 34.9 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Presenilin PF01080.17 CDI75516.1 - 6.5 5.4 27.2 8.3 5.1 27.2 1.2 1 0 0 1 1 1 0 Presenilin DUF3824 PF12868.7 CDI75516.1 - 7 7.3 16.1 13 6.4 15.9 1.5 1 1 0 1 1 1 0 Domain of unknwon function (DUF3824) PAP1 PF08601.10 CDI75516.1 - 8.1 6.1 27.6 9.3 5.9 27.6 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 CemA PF03040.14 CDI75516.1 - 8.3 6.3 11.9 9.5 6.1 11.9 1.2 1 0 0 1 1 1 0 CemA family Membralin PF09746.9 CDI75516.1 - 8.3 5.3 20.2 9.6 5.1 20.2 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF3801 PF12687.7 CDI75516.1 - 8.8 6.4 25.9 13 5.8 25.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) DUF4820 PF16091.5 CDI75518.1 - 0.0075 15.7 19.4 0.0075 15.7 19.4 3.7 3 1 0 3 3 3 1 Domain of unknown function (DUF4820) CD20 PF04103.15 CDI75518.1 - 1 9.4 12.3 0.12 12.5 1.1 3.6 2 1 1 3 3 3 0 CD20-like family Photo_RC PF00124.19 CDI75518.1 - 1.2 8.3 5.1 2.3 7.4 3.5 2.2 1 1 1 2 2 2 0 Photosynthetic reaction centre protein Nas2_N PF18265.1 CDI75520.1 - 2.6e-26 91.3 0.0 3.5e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 Nas2 N_terminal domain SPARC_Ca_bdg PF10591.9 CDI75520.1 - 0.088 13.1 0.2 0.15 12.4 0.2 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region SLBP_RNA_bind PF15247.6 CDI75521.1 - 0.36 11.0 5.5 0.15 12.2 2.0 2.2 2 0 0 2 2 2 0 Histone RNA hairpin-binding protein RNA-binding domain NPV_P10 PF05531.12 CDI75521.1 - 8.7 6.9 17.6 0.8 10.2 2.3 5.2 3 2 1 5 5 5 0 Nucleopolyhedrovirus P10 protein Ribophorin_I PF04597.14 CDI75522.1 - 1.1e-68 232.5 0.0 1.5e-68 232.0 0.0 1.2 1 0 0 1 1 1 1 Ribophorin I SET PF00856.28 CDI75523.1 - 9.5e-07 29.4 0.0 7.5e-06 26.4 0.0 2.2 2 0 0 2 2 2 1 SET domain TamB PF04357.13 CDI75523.1 - 0.15 11.2 0.1 0.25 10.5 0.1 1.2 1 0 0 1 1 1 0 TamB, inner membrane protein subunit of TAM complex RNA_polI_A34 PF08208.11 CDI75524.1 - 5 7.2 11.5 0.96 9.5 0.5 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 AAA_23 PF13476.6 CDI75525.1 - 0.0044 17.5 16.9 0.18 12.3 0.5 2.3 2 0 0 2 2 2 2 AAA domain RskA PF10099.9 CDI75525.1 - 0.0063 16.8 15.3 0.0063 16.8 15.3 5.0 2 1 2 4 4 4 3 Anti-sigma-K factor rskA Pinin_SDK_memA PF04696.13 CDI75525.1 - 0.046 13.8 31.1 0.53 10.3 7.9 2.3 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region SOBP PF15279.6 CDI75525.1 - 0.079 13.6 43.3 0.057 14.0 23.2 2.4 2 0 0 2 2 2 0 Sine oculis-binding protein SART-1 PF03343.13 CDI75525.1 - 0.11 11.0 29.4 0.26 9.8 7.7 2.2 2 0 0 2 2 2 0 SART-1 family Spt20 PF12090.8 CDI75525.1 - 0.28 10.8 81.6 0.062 12.9 28.1 4.1 4 0 0 4 4 4 0 Spt20 family Peptidase_S49_N PF08496.10 CDI75525.1 - 1.4 9.0 14.8 3.2 7.8 2.8 2.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal U1snRNP70_N PF12220.8 CDI75525.1 - 7.5 7.3 16.5 13 6.5 3.2 2.7 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal WBP-1 PF11669.8 CDI75525.1 - 8.5 7.1 13.1 11 6.8 1.9 3.1 2 0 0 2 2 2 0 WW domain-binding protein 1 RskA PF10099.9 CDI75526.1 - 0.00039 20.8 13.2 0.00039 20.8 13.2 2.2 1 1 1 2 2 2 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI75526.1 - 0.02 14.5 10.0 0.023 14.3 10.0 1.1 1 0 0 1 1 1 0 Spt20 family FAD_SOX PF18371.1 CDI75526.1 - 0.034 14.5 0.5 0.056 13.8 0.5 1.3 1 0 0 1 1 1 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase CRISPR_Cas9_WED PF18061.1 CDI75526.1 - 0.12 12.5 0.0 0.16 12.0 0.0 1.1 1 0 0 1 1 1 0 CRISPR-Cas9 WED domain RIFIN PF02009.16 CDI75526.1 - 0.15 11.9 9.4 0.2 11.5 9.4 1.1 1 0 0 1 1 1 0 Rifin TFIIA PF03153.13 CDI75526.1 - 0.26 11.3 12.4 0.33 10.9 12.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI75526.1 - 0.42 9.5 6.0 0.54 9.1 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) E_Pc_C PF06752.12 CDI75526.1 - 0.48 10.5 26.9 0.037 14.1 19.3 2.3 2 0 0 2 2 2 0 Enhancer of Polycomb C-terminus Spt20 PF12090.8 CDI75527.1 - 0.0095 15.6 3.5 0.0095 15.6 3.5 2.3 2 0 0 2 2 2 1 Spt20 family TCP PF03634.13 CDI75527.1 - 0.02 15.4 7.5 0.02 15.4 7.5 2.8 3 0 0 3 3 3 0 TCP family transcription factor PAT1 PF09770.9 CDI75527.1 - 0.037 12.3 15.6 0.01 14.1 11.5 1.8 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Lin-8 PF03353.15 CDI75527.1 - 0.051 13.1 25.0 0.26 10.8 1.6 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist MAP70 PF07058.11 CDI75527.1 - 0.45 9.2 6.5 0.61 8.8 6.5 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 PRP1_N PF06424.12 CDI75527.1 - 0.47 10.8 10.2 0.14 12.6 4.1 2.4 3 0 0 3 3 3 0 PRP1 splicing factor, N-terminal Serinc PF03348.15 CDI75527.1 - 1.2 8.0 5.1 1.8 7.4 5.1 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) YscJ_FliF_C PF08345.11 CDI75527.1 - 1.2 9.4 17.2 1.1 9.6 0.7 2.4 2 0 0 2 2 2 0 Flagellar M-ring protein C-terminal CLN3 PF02487.17 CDI75527.1 - 1.4 7.9 6.1 0.75 8.8 3.5 1.7 2 0 0 2 2 2 0 CLN3 protein Gti1_Pac2 PF09729.9 CDI75527.1 - 2.7 8.0 17.2 10 6.2 0.2 2.3 2 0 0 2 2 2 0 Gti1/Pac2 family RIC3 PF15361.6 CDI75527.1 - 4.3 7.7 9.3 1.8 8.9 5.2 2.3 3 0 0 3 3 3 0 Resistance to inhibitors of cholinesterase homologue 3 NPR3 PF03666.13 CDI75527.1 - 7.3 5.3 14.8 4.4 6.0 9.2 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4407 PF14362.6 CDI75527.1 - 8.1 5.7 8.0 4.4 6.6 4.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Membralin PF09746.9 CDI75527.1 - 8.3 5.3 6.4 15 4.5 6.4 1.3 1 0 0 1 1 1 0 Tumour-associated protein eIF-3_zeta PF05091.12 CDI75527.1 - 9.2 5.1 15.4 1.3 8.0 9.7 1.9 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) WD40 PF00400.32 CDI75528.1 - 6.8e-06 26.7 0.5 0.084 13.8 0.0 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat DUF2722 PF10846.8 CDI75528.1 - 6.2e-05 22.1 0.4 6.2e-05 22.1 0.4 6.2 4 1 1 5 5 5 1 Protein of unknown function (DUF2722) PIP5K PF01504.18 CDI75528.1 - 7.7e-05 22.0 18.2 0.037 13.3 5.9 3.5 2 1 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Androgen_recep PF02166.16 CDI75528.1 - 0.00025 20.0 8.7 0.00025 20.0 8.7 10.0 5 3 4 9 9 9 1 Androgen receptor ANAPC4_WD40 PF12894.7 CDI75528.1 - 0.00037 20.7 0.0 0.49 10.7 0.0 2.8 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain SAGA-Tad1 PF12767.7 CDI75528.1 - 0.071 12.8 36.2 0.063 13.0 16.1 3.3 3 0 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit TBP PF00352.21 CDI75530.1 - 8.5e-34 115.4 0.0 2.3e-22 78.7 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) Utp14 PF04615.13 CDI75532.1 - 0.00038 19.2 19.2 0.00038 19.2 19.2 6.4 3 2 2 5 5 5 2 Utp14 protein Lin-8 PF03353.15 CDI75532.1 - 0.0027 17.3 10.6 0.0027 17.3 10.6 9.8 7 3 0 8 8 8 3 Ras-mediated vulval-induction antagonist DUF1645 PF07816.11 CDI75532.1 - 0.0053 17.4 5.8 0.0053 17.4 5.8 10.9 6 3 4 11 11 11 2 Protein of unknown function (DUF1645) DUF4201 PF13870.6 CDI75533.1 - 2.2e-18 66.6 22.2 2.2e-18 66.6 22.2 3.8 1 1 2 3 3 3 2 Domain of unknown function (DUF4201) Ground-like PF04155.18 CDI75533.1 - 0.9 10.3 4.5 0.89 10.3 0.5 2.8 2 0 0 2 2 2 0 Ground-like domain Ank_2 PF12796.7 CDI75534.1 - 2.1e-25 89.1 4.3 5.3e-10 39.8 1.0 4.6 1 1 4 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDI75534.1 - 3e-24 84.7 10.4 2.9e-11 43.4 0.3 6.0 4 2 1 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 CDI75534.1 - 1.3e-21 76.0 13.3 0.0022 18.4 0.1 7.4 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.6 CDI75534.1 - 1e-19 70.6 2.9 3.1e-07 30.8 0.1 6.0 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI75534.1 - 7.4e-14 50.5 7.4 0.11 13.1 0.0 7.3 7 0 0 7 7 7 3 Ankyrin repeat Sushi PF00084.20 CDI75534.1 - 7.9e-07 29.6 0.1 1.4e-06 28.8 0.1 1.4 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) DnaJ PF00226.31 CDI75535.1 - 7e-20 70.9 0.4 1.5e-19 69.9 0.4 1.6 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 CDI75535.1 - 2.5e-15 56.3 0.0 7.8e-13 48.2 0.0 2.1 1 1 1 2 2 2 2 Sec63 Brl domain Vps55 PF04133.14 CDI75535.1 - 0.14 12.1 0.9 1.3 9.0 0.1 2.6 3 0 0 3 3 3 0 Vacuolar protein sorting 55 FAM104 PF15434.6 CDI75536.1 - 0.016 15.8 1.1 0.016 15.8 1.1 4.2 3 1 0 4 4 4 0 Family 104 TIP49 PF06068.13 CDI75537.1 - 4.5e-57 193.8 7.7 6.6e-30 104.5 2.5 2.6 2 1 1 3 3 2 2 TIP49 P-loop domain AAA PF00004.29 CDI75537.1 - 1.4e-11 44.9 2.5 3.1e-07 30.9 0.1 3.9 3 1 1 4 4 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDI75537.1 - 4.7e-09 36.2 3.7 0.00015 21.6 0.1 3.0 2 1 1 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CDI75537.1 - 1.3e-07 31.7 1.0 0.014 15.4 0.2 2.7 1 1 1 2 2 2 2 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 CDI75537.1 - 6.4e-06 25.9 8.4 0.0095 15.5 0.3 3.4 2 1 1 3 3 3 2 AAA domain Zeta_toxin PF06414.12 CDI75537.1 - 7.3e-06 25.4 4.2 0.0017 17.7 0.7 3.5 2 2 1 3 3 2 2 Zeta toxin APS_kinase PF01583.20 CDI75537.1 - 0.0001 22.3 0.1 0.52 10.2 0.0 2.8 1 1 1 2 2 2 2 Adenylylsulphate kinase RNA_helicase PF00910.22 CDI75537.1 - 0.00014 22.2 0.2 0.85 10.0 0.0 3.0 1 1 1 2 2 2 2 RNA helicase DnaB_C PF03796.15 CDI75537.1 - 0.00018 20.9 0.1 0.00018 20.9 0.1 3.9 3 1 1 4 4 3 2 DnaB-like helicase C terminal domain AAA_17 PF13207.6 CDI75537.1 - 0.00094 19.6 0.1 0.00094 19.6 0.1 3.9 5 0 0 5 5 3 1 AAA domain AAA_18 PF13238.6 CDI75537.1 - 0.0011 19.5 0.5 0.054 14.0 0.0 3.4 4 0 0 4 4 2 2 AAA domain TsaE PF02367.17 CDI75537.1 - 0.0012 18.8 2.7 0.26 11.3 0.4 2.7 1 1 1 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 CDI75537.1 - 0.0014 18.6 2.7 0.043 13.7 0.1 3.8 4 1 1 5 5 2 2 NACHT domain AAA_3 PF07726.11 CDI75537.1 - 0.0017 18.2 0.4 2.1 8.2 0.1 2.8 1 1 1 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 CDI75537.1 - 0.0017 17.7 1.1 0.057 12.6 0.0 4.6 4 1 1 5 5 4 2 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 CDI75537.1 - 0.0031 17.9 0.1 0.0031 17.9 0.1 4.2 2 2 1 3 3 2 2 AAA ATPase domain TFIIA PF03153.13 CDI75537.1 - 0.0032 17.6 4.1 0.0032 17.6 4.1 3.1 2 1 1 3 3 2 2 Transcription factor IIA, alpha/beta subunit OmpH PF03938.14 CDI75537.1 - 0.0059 16.9 7.4 0.0059 16.9 7.4 3.5 3 0 0 3 3 3 1 Outer membrane protein (OmpH-like) AAA_11 PF13086.6 CDI75537.1 - 0.014 15.2 31.2 1.2 8.8 0.1 5.2 3 1 2 5 5 5 0 AAA domain AAA_7 PF12775.7 CDI75537.1 - 0.022 14.3 10.0 0.11 12.0 0.0 3.0 3 1 1 4 4 2 0 P-loop containing dynein motor region ATPase PF06745.13 CDI75537.1 - 0.022 14.1 10.2 0.026 13.9 0.1 3.0 2 1 1 3 3 3 0 KaiC Cytidylate_kin2 PF13189.6 CDI75537.1 - 0.03 14.5 1.2 9.9 6.3 0.1 2.9 1 1 1 2 2 2 0 Cytidylate kinase-like family Pex14_N PF04695.13 CDI75537.1 - 0.031 14.9 0.7 0.031 14.9 0.7 4.0 2 1 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region AAA_29 PF13555.6 CDI75537.1 - 0.046 13.5 1.6 6.3 6.6 0.1 2.7 1 1 1 2 2 2 0 P-loop containing region of AAA domain DUF3807 PF12720.7 CDI75537.1 - 0.052 13.8 31.9 0.88 9.8 12.5 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) CPT PF07931.12 CDI75537.1 - 0.1 12.5 7.0 1.3 8.9 0.1 3.3 2 1 1 3 3 2 0 Chloramphenicol phosphotransferase-like protein GvpD PF07088.11 CDI75537.1 - 0.1 11.2 0.5 7 5.1 0.1 2.1 1 1 1 2 2 2 0 GvpD gas vesicle protein Spore_YhcN_YlaJ PF09580.10 CDI75537.1 - 0.12 12.4 22.0 1.5 8.9 0.1 3.3 3 0 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Tim54 PF11711.8 CDI75537.1 - 0.19 10.5 21.4 0.062 12.1 5.7 3.1 3 0 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 TCP PF03634.13 CDI75537.1 - 0.25 11.9 26.8 2.2 8.8 12.4 3.4 3 0 0 3 3 3 0 TCP family transcription factor NTPase_1 PF03266.15 CDI75537.1 - 0.35 10.8 5.5 4 7.3 0.1 2.8 2 1 1 3 3 2 0 NTPase FAM60A PF15396.6 CDI75537.1 - 0.55 10.2 18.3 3.6 7.5 8.8 3.2 3 0 0 3 3 3 0 Protein Family FAM60A EOS1 PF12326.8 CDI75537.1 - 0.57 10.1 11.6 4.4 7.2 2.3 3.3 3 0 0 3 3 3 0 N-glycosylation protein AAA_22 PF13401.6 CDI75537.1 - 0.63 10.3 0.0 0.63 10.3 0.0 4.7 4 2 2 6 6 4 0 AAA domain DUF2052 PF09747.9 CDI75537.1 - 0.69 10.0 22.8 2.6 8.2 8.1 3.2 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 CDI75537.1 - 0.76 8.0 12.2 0.34 9.2 2.7 2.9 3 0 0 3 3 3 0 CDC45-like protein Endostatin PF06482.11 CDI75537.1 - 2.1 7.8 26.9 3.2 7.1 14.6 3.1 3 0 0 3 3 3 0 Collagenase NC10 and Endostatin SpoIIP PF07454.11 CDI75537.1 - 2.9 7.3 29.7 0.11 11.9 6.4 3.1 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) FAM76 PF16046.5 CDI75537.1 - 3 7.1 30.2 0.53 9.6 13.0 3.1 3 0 0 3 3 3 0 FAM76 protein eIF-3_zeta PF05091.12 CDI75537.1 - 3.3 6.6 38.6 0.25 10.3 10.8 3.1 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) BORG_CEP PF14957.6 CDI75537.1 - 3.5 8.8 17.3 1.9 9.7 6.0 3.3 3 0 0 3 3 3 0 Cdc42 effector SARAF PF06682.12 CDI75537.1 - 3.6 7.2 35.3 0.79 9.3 12.0 3.1 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis Mg_chelatase PF01078.21 CDI75537.1 - 4.2 6.7 22.2 0.15 11.4 0.1 4.0 3 1 1 4 4 3 0 Magnesium chelatase, subunit ChlI EIF4E-T PF10477.9 CDI75537.1 - 9.9 4.8 42.6 0.95 8.2 0.6 3.1 3 0 0 3 3 3 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Hamartin PF04388.12 CDI75538.1 - 6.8 5.2 36.1 9.6 4.7 36.1 1.3 1 0 0 1 1 1 0 Hamartin protein SR-25 PF10500.9 CDI75539.1 - 0.013 15.1 9.5 0.013 15.1 9.5 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein MutS_II PF05188.17 CDI75539.1 - 0.24 11.7 3.8 0.19 12.0 1.2 2.0 1 1 1 2 2 2 0 MutS domain II GREB1 PF15782.5 CDI75539.1 - 1 6.4 14.2 1.2 6.2 14.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Lin-8 PF03353.15 CDI75539.1 - 1.1 8.8 11.1 1.8 8.0 11.1 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist LMBR1 PF04791.16 CDI75539.1 - 3.8 6.3 4.2 4.3 6.1 4.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein SPX PF03105.19 CDI75539.1 - 4.8 7.0 10.5 6.9 6.5 10.5 1.2 1 0 0 1 1 1 0 SPX domain Kinesin_assoc PF16183.5 CDI75539.1 - 7.2 6.7 6.2 16 5.6 6.2 1.8 1 1 0 1 1 1 0 Kinesin-associated Ribosomal_60s PF00428.19 CDI75540.1 - 0.04 14.5 3.5 0.04 14.5 3.5 2.7 3 0 0 3 3 3 0 60s Acidic ribosomal protein GT87 PF09594.10 CDI75541.1 - 0.00012 21.9 23.0 0.002 17.9 4.8 3.3 2 1 1 3 3 3 2 Glycosyltransferase family 87 RskA PF10099.9 CDI75541.1 - 0.0052 17.1 12.3 0.0052 17.1 12.3 5.3 1 1 2 4 4 4 2 Anti-sigma-K factor rskA SARAF PF06682.12 CDI75541.1 - 1.9 8.0 36.2 7.5 6.1 0.3 2.7 2 1 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis NPR3 PF03666.13 CDI75542.1 - 0.013 14.3 7.8 1.5 7.6 5.3 2.3 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Ribosomal_60s PF00428.19 CDI75542.1 - 0.019 15.6 4.6 0.019 15.6 4.6 4.2 2 1 2 4 4 4 0 60s Acidic ribosomal protein PPL5 PF18168.1 CDI75542.1 - 0.12 11.6 4.9 0.25 10.6 4.9 1.5 1 0 0 1 1 1 0 Prim-pol family 5 BT1 PF03092.16 CDI75542.1 - 0.14 10.4 0.4 0.18 10.0 0.4 1.2 1 0 0 1 1 1 0 BT1 family Ureide_permease PF07168.11 CDI75542.1 - 0.31 9.8 1.9 0.47 9.2 1.9 1.3 1 0 0 1 1 1 0 Ureide permease Mito_carr PF00153.27 CDI75542.1 - 0.36 10.8 0.0 0.36 10.8 0.0 2.2 2 0 0 2 2 1 0 Mitochondrial carrier protein Nipped-B_C PF12830.7 CDI75542.1 - 0.64 9.9 7.3 0.068 13.1 2.2 2.0 2 1 0 2 2 2 0 Sister chromatid cohesion C-terminus CCDC53 PF10152.9 CDI75542.1 - 0.72 10.3 19.2 1.1 9.7 8.3 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Connexin PF00029.19 CDI75542.1 - 0.77 9.5 2.9 1.5 8.5 2.9 1.4 1 0 0 1 1 1 0 Connexin Myc_N PF01056.18 CDI75542.1 - 0.91 9.4 15.9 3 7.7 14.7 2.0 1 1 1 2 2 2 0 Myc amino-terminal region DUF913 PF06025.12 CDI75542.1 - 1.1 8.1 12.4 0.081 11.9 6.8 1.7 1 1 1 2 2 2 0 Domain of Unknown Function (DUF913) MRI PF15325.6 CDI75542.1 - 1.5 9.9 11.4 14 6.9 0.3 2.5 2 0 0 2 2 2 0 Modulator of retrovirus infection SAPS PF04499.15 CDI75542.1 - 1.6 7.4 13.9 2.5 6.8 13.9 1.4 1 1 0 1 1 1 0 SIT4 phosphatase-associated protein F-protein PF00469.20 CDI75542.1 - 2 7.9 7.0 4.9 6.7 7.0 1.6 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Phage_int_SAM_1 PF02899.17 CDI75542.1 - 2.5 8.5 9.6 3.4 8.1 0.2 3.0 3 0 0 3 3 2 0 Phage integrase, N-terminal SAM-like domain TFIIA PF03153.13 CDI75542.1 - 2.5 8.0 39.7 4.8 7.1 39.7 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4820 PF16091.5 CDI75542.1 - 3.4 7.0 11.5 0.78 9.1 3.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Maf1 PF09174.10 CDI75542.1 - 3.7 7.7 7.7 0.88 9.7 2.5 2.1 2 0 0 2 2 2 0 Maf1 regulator DUF4746 PF15928.5 CDI75542.1 - 3.9 6.8 10.3 0.32 10.4 5.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Spt20 PF12090.8 CDI75542.1 - 3.9 7.0 35.4 5.8 6.5 23.2 2.2 2 0 0 2 2 2 0 Spt20 family YscJ_FliF_C PF08345.11 CDI75542.1 - 4.4 7.6 15.8 1.8 8.9 8.6 2.2 2 0 0 2 2 2 0 Flagellar M-ring protein C-terminal RR_TM4-6 PF06459.12 CDI75542.1 - 4.7 6.9 18.5 0.43 10.3 14.3 1.4 2 0 0 2 2 1 0 Ryanodine Receptor TM 4-6 HGTP_anticodon2 PF12745.7 CDI75542.1 - 6 6.3 11.7 2.1 7.8 6.0 2.3 2 1 0 2 2 2 0 Anticodon binding domain of tRNAs DUF4770 PF15994.5 CDI75542.1 - 7.1 6.8 15.1 1.3 9.2 10.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) PH_4 PF15404.6 CDI75542.1 - 9.7 5.9 8.0 0.74 9.6 2.8 1.9 2 0 0 2 2 1 0 Pleckstrin homology domain Spore_coat_CotO PF14153.6 CDI75542.1 - 9.9 6.0 24.4 0.82 9.6 12.9 2.2 2 0 0 2 2 2 0 Spore coat protein CotO ETRAMP PF09716.10 CDI75543.1 - 3.1 7.9 4.4 63 3.7 2.3 3.0 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) OTU PF02338.19 CDI75546.1 - 5e-05 23.8 0.0 5e-05 23.8 0.0 2.0 1 1 1 2 2 1 1 OTU-like cysteine protease TFIIA PF03153.13 CDI75546.1 - 0.0074 16.3 29.4 0.0079 16.2 29.4 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit HemX PF04375.14 CDI75546.1 - 0.045 13.0 24.5 0.056 12.7 24.5 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Med15 PF09606.10 CDI75546.1 - 0.071 11.8 28.1 0.084 11.5 28.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4569 PF15133.6 CDI75546.1 - 0.075 12.7 9.1 0.088 12.5 9.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) FAM60A PF15396.6 CDI75546.1 - 0.19 11.7 3.2 0.23 11.4 3.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Sec62 PF03839.16 CDI75546.1 - 0.22 11.0 4.0 0.26 10.8 4.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Zip PF02535.22 CDI75546.1 - 0.22 10.7 1.8 0.25 10.5 1.8 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Rgp1 PF08737.10 CDI75546.1 - 0.24 10.5 8.1 0.3 10.2 8.1 1.0 1 0 0 1 1 1 0 Rgp1 DUF775 PF05603.12 CDI75546.1 - 0.27 10.7 8.0 0.47 9.9 8.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Connexin PF00029.19 CDI75546.1 - 0.31 10.7 3.4 0.44 10.3 3.4 1.2 1 0 0 1 1 1 0 Connexin Cellulose_synt PF03552.14 CDI75546.1 - 0.39 9.2 0.8 0.47 8.9 0.8 1.0 1 0 0 1 1 1 0 Cellulose synthase DUF2828 PF11443.8 CDI75546.1 - 0.48 8.4 5.9 0.57 8.2 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SLM4 PF16818.5 CDI75546.1 - 0.5 10.3 4.4 1.2 9.1 4.4 1.6 1 1 0 1 1 1 0 Protein SLM4 Hydin_ADK PF17213.3 CDI75546.1 - 0.53 10.5 6.9 0.72 10.1 6.9 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Peptidase_S49_N PF08496.10 CDI75546.1 - 0.58 10.2 6.8 0.74 9.9 6.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal GET2 PF08690.10 CDI75546.1 - 0.86 9.2 14.4 1 8.9 14.4 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 V_ATPase_I PF01496.19 CDI75546.1 - 0.92 7.3 10.6 1.1 7.1 10.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI75546.1 - 1 8.3 6.1 1.3 8.0 6.1 1.1 1 0 0 1 1 1 0 CLN3 protein Presenilin PF01080.17 CDI75546.1 - 1.1 8.0 11.1 1.3 7.7 11.1 1.0 1 0 0 1 1 1 0 Presenilin Kei1 PF08552.11 CDI75546.1 - 1.4 8.8 4.8 1.9 8.3 4.8 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 eIF-3_zeta PF05091.12 CDI75546.1 - 1.7 7.5 12.3 2.1 7.2 12.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Neur_chan_memb PF02932.16 CDI75546.1 - 2.2 8.3 6.7 2.5 8.1 6.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CreD PF06123.12 CDI75546.1 - 2.3 6.9 6.2 2.7 6.7 6.2 1.1 1 0 0 1 1 1 0 Inner membrane protein CreD AUX_IAA PF02309.16 CDI75546.1 - 2.4 8.0 6.1 3 7.6 6.1 1.1 1 0 0 1 1 1 0 AUX/IAA family PAT1 PF09770.9 CDI75546.1 - 3.8 5.7 23.2 4.6 5.4 23.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RRP7 PF12923.7 CDI75547.1 - 0.00085 19.4 5.5 0.0012 18.9 5.5 1.2 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain SR-25 PF10500.9 CDI75547.1 - 0.018 14.7 12.6 0.018 14.7 12.6 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 CDI75547.1 - 0.086 13.1 31.0 0.15 12.3 31.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF755) WRNPLPNID PF15017.6 CDI75547.1 - 0.096 13.6 8.2 0.24 12.3 1.0 2.3 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box DUF2512 PF10710.9 CDI75547.1 - 0.12 12.0 1.3 0.21 11.2 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2512) Lin-8 PF03353.15 CDI75547.1 - 0.14 11.7 16.0 0.18 11.3 16.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SpecificRecomb PF10136.9 CDI75547.1 - 0.26 9.5 13.2 0.31 9.3 13.2 1.0 1 0 0 1 1 1 0 Site-specific recombinase Macoilin PF09726.9 CDI75547.1 - 0.43 9.1 15.0 0.55 8.7 15.0 1.0 1 0 0 1 1 1 0 Macoilin family DUF2126 PF09899.9 CDI75547.1 - 0.44 8.6 6.4 0.47 8.5 6.4 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Neur_chan_memb PF02932.16 CDI75547.1 - 0.87 9.6 9.3 0.97 9.4 9.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GET2 PF08690.10 CDI75547.1 - 1.1 8.9 15.0 1.3 8.6 15.0 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Hydin_ADK PF17213.3 CDI75547.1 - 1.7 8.9 14.0 2.1 8.6 14.0 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF1754 PF08555.10 CDI75547.1 - 1.8 9.4 12.5 2.6 8.9 0.6 2.2 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) DUF5349 PF17298.2 CDI75547.1 - 2.3 7.9 21.4 3 7.5 21.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5349) DUF2844 PF11005.8 CDI75547.1 - 2.9 7.9 12.0 4.6 7.3 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2844) Zip PF02535.22 CDI75547.1 - 3.8 6.7 5.0 4.7 6.3 5.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter GREB1 PF15782.5 CDI75547.1 - 4.2 4.3 17.5 4.7 4.2 17.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer STALD PF18185.1 CDI75547.1 - 5.6 6.2 7.5 0.73 9.1 1.2 1.9 1 1 1 2 2 2 0 Sir2- and TIR-associating SLOG family CSG2 PF16965.5 CDI75547.1 - 6.6 5.6 8.3 8.1 5.3 8.3 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Pkinase PF00069.25 CDI75549.1 - 6.1e-80 268.4 0.0 9e-80 267.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI75549.1 - 1.2e-36 126.3 0.0 1.7e-36 125.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 CDI75549.1 - 2.3e-16 58.1 1.0 1.3e-08 33.8 1.5 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CDI75549.1 - 1.5e-12 47.8 0.1 1.9e-11 44.3 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CDI75549.1 - 6.3e-12 44.4 0.7 0.00011 21.9 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 CDI75549.1 - 1.8e-11 43.7 0.3 1.2e-06 28.2 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CDI75549.1 - 2.4e-11 42.6 2.6 0.00019 20.8 1.6 2.5 2 0 0 2 2 2 2 EF hand Pkinase_fungal PF17667.1 CDI75549.1 - 3.2e-06 26.2 0.0 4.9e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDI75549.1 - 8.8e-05 21.9 0.0 0.00016 21.1 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 CDI75549.1 - 0.00031 20.7 0.0 0.00055 19.9 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family EF-hand_9 PF14658.6 CDI75549.1 - 0.019 15.3 0.2 2.3 8.6 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain Kdo PF06293.14 CDI75549.1 - 0.02 14.3 0.0 0.037 13.4 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Dockerin_1 PF00404.18 CDI75549.1 - 0.04 14.1 0.2 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 Dockerin type I domain DUF3775 PF12616.8 CDI75549.1 - 0.073 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) B2 PF11473.8 CDI75550.1 - 0.011 15.5 0.2 4.7 7.1 0.0 2.5 2 0 0 2 2 2 0 RNA binding protein B2 ApoL PF05461.11 CDI75550.1 - 0.2 11.0 5.2 0.04 13.2 1.3 1.8 2 0 0 2 2 2 0 Apolipoprotein L NEMO PF11577.8 CDI75550.1 - 0.77 9.8 5.5 0.12 12.4 0.8 2.1 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO DUF4407 PF14362.6 CDI75550.1 - 2.3 7.5 6.3 11 5.3 6.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TFIIA PF03153.13 CDI75551.1 - 4.1e-05 23.8 15.9 5.9e-05 23.2 15.9 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Fucokinase PF07959.12 CDI75551.1 - 0.00033 19.7 0.8 0.00047 19.2 0.8 1.1 1 0 0 1 1 1 1 L-fucokinase DUF2828 PF11443.8 CDI75551.1 - 0.0099 14.0 1.1 0.015 13.4 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) FAM150 PF15129.6 CDI75551.1 - 1.3 9.2 5.3 0.8 9.9 0.7 2.4 2 0 0 2 2 2 0 FAM150 family DASH_Dad2 PF08654.10 CDI75551.1 - 4.4 7.8 12.8 1.6 9.2 1.5 3.3 3 0 0 3 3 3 0 DASH complex subunit Dad2 SAS-6_N PF16531.5 CDI75552.1 - 4.1e-28 97.8 2.8 6.7e-28 97.1 2.8 1.4 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal TIP49 PF06068.13 CDI75553.1 - 7.1e-158 525.4 0.0 8.8e-158 525.1 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CDI75553.1 - 1.2e-14 54.2 0.0 2.5e-13 49.9 0.0 2.9 1 1 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 CDI75553.1 - 1.7e-12 47.9 0.0 1.6e-08 35.1 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDI75553.1 - 2.9e-10 40.1 0.2 2.8e-07 30.4 0.1 2.3 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDI75553.1 - 2.2e-06 28.0 0.1 0.032 14.5 0.1 2.9 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CDI75553.1 - 1.1e-05 25.4 0.1 0.0016 18.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDI75553.1 - 1.4e-05 25.5 0.0 0.0021 18.5 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.6 CDI75553.1 - 0.00023 21.5 0.1 0.083 13.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CDI75553.1 - 0.00046 19.6 0.3 0.018 14.5 0.1 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CDI75553.1 - 0.00082 19.1 0.1 0.41 10.3 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_25 PF13481.6 CDI75553.1 - 0.00082 19.0 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDI75553.1 - 0.0017 18.9 0.0 0.0046 17.5 0.0 1.7 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.17 CDI75553.1 - 0.0034 17.1 0.0 0.0063 16.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_7 PF12775.7 CDI75553.1 - 0.0039 16.7 0.1 0.024 14.2 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region DnaB_C PF03796.15 CDI75553.1 - 0.0043 16.4 0.0 0.0081 15.5 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_28 PF13521.6 CDI75553.1 - 0.0075 16.5 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDI75553.1 - 0.0081 16.3 0.0 0.039 14.1 0.0 2.1 3 0 0 3 3 2 1 AAA domain ResIII PF04851.15 CDI75553.1 - 0.0082 16.2 0.0 0.18 11.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_14 PF13173.6 CDI75553.1 - 0.012 15.7 0.0 5.4 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CDI75553.1 - 0.012 14.9 0.1 0.03 13.6 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin Parvo_NS1 PF01057.17 CDI75553.1 - 0.021 13.9 0.1 0.04 13.0 0.1 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF2075 PF09848.9 CDI75553.1 - 0.029 13.6 0.0 0.077 12.2 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 CDI75553.1 - 0.029 14.4 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 CDI75553.1 - 0.031 14.0 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 CDI75553.1 - 0.034 13.3 0.0 1.8 7.6 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_30 PF13604.6 CDI75553.1 - 0.035 13.8 0.1 0.46 10.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CDI75553.1 - 0.042 14.3 0.0 0.098 13.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase PhoH PF02562.16 CDI75553.1 - 0.048 13.1 0.1 0.096 12.1 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein NTPase_1 PF03266.15 CDI75553.1 - 0.059 13.3 0.1 0.23 11.3 0.0 2.1 2 0 0 2 2 2 0 NTPase Rad17 PF03215.15 CDI75553.1 - 0.062 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain NACHT PF05729.12 CDI75553.1 - 0.064 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Torsin PF06309.11 CDI75553.1 - 0.077 13.1 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Torsin TniB PF05621.11 CDI75553.1 - 0.087 12.2 0.0 1.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_17 PF13207.6 CDI75553.1 - 0.087 13.2 0.2 0.5 10.8 0.0 2.2 2 1 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 CDI75553.1 - 0.15 12.1 0.0 8.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain G6PD_C PF02781.16 CDI75554.1 - 3e-84 282.7 0.0 8e-42 143.4 0.0 2.2 1 1 1 2 2 2 2 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 CDI75554.1 - 2.4e-47 161.8 0.0 1.7e-46 159.1 0.0 2.3 2 1 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Glucosamine_iso PF01182.20 CDI75554.1 - 2e-36 126.0 0.0 3.4e-36 125.2 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Pantoate_transf PF02548.15 CDI75555.1 - 2.3e-51 174.7 2.1 2.3e-51 174.7 2.1 2.0 2 1 1 3 3 3 1 Ketopantoate hydroxymethyltransferase ApbA_C PF08546.11 CDI75555.1 - 7.4e-24 84.3 0.1 1.5e-23 83.4 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal PEP_mutase PF13714.6 CDI75555.1 - 0.00066 19.2 0.9 0.0014 18.2 0.9 1.5 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ApbA PF02558.16 CDI75555.1 - 0.09 12.4 0.0 9.5 5.9 0.0 2.6 2 1 0 2 2 2 0 Ketopantoate reductase PanE/ApbA DUF1778 PF08681.11 CDI75555.1 - 0.12 12.3 0.1 0.34 10.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1778) DUF4010 PF13194.6 CDI75555.1 - 0.79 9.4 3.8 0.49 10.0 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4010) REPA_OB_2 PF16900.5 CDI75556.1 - 1.6e-14 53.6 0.0 3.1e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Replication protein A OB domain Rep_fac-A_C PF08646.10 CDI75556.1 - 1.4e-10 41.1 5.5 8.4e-08 32.1 5.5 3.1 1 1 0 1 1 1 1 Replication factor-A C terminal domain zinc-ribbons_6 PF07191.12 CDI75556.1 - 0.045 13.7 1.8 0.092 12.7 1.8 1.5 1 0 0 1 1 1 0 zinc-ribbons tRNA_anti-codon PF01336.25 CDI75557.1 - 3.6e-05 23.7 0.1 0.00014 21.8 0.0 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain REPA_OB_2 PF16900.5 CDI75557.1 - 0.11 12.4 0.0 0.3 11.0 0.0 1.7 1 1 0 1 1 1 0 Replication protein A OB domain TFIIA PF03153.13 CDI75558.1 - 0.028 14.4 8.7 0.031 14.3 8.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI75558.1 - 0.65 8.7 3.8 0.79 8.4 3.8 1.1 1 0 0 1 1 1 0 Presenilin CCDC53 PF10152.9 CDI75558.1 - 6.8 7.1 9.0 1.5 9.2 5.6 1.8 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Tim17 PF02466.19 CDI75559.1 - 2.5e-22 79.3 5.1 4e-22 78.7 5.1 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family HA2 PF04408.23 CDI75560.1 - 5.9e-11 42.6 0.1 2.2e-10 40.8 0.1 2.0 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDI75560.1 - 9.9e-10 38.7 0.6 2.4e-09 37.4 0.1 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold SR-25 PF10500.9 CDI75560.1 - 1.6 8.3 20.9 0.0098 15.5 6.9 2.7 2 1 0 3 3 3 0 Nuclear RNA-splicing-associated protein CRAL_TRIO PF00650.20 CDI75561.1 - 1.9e-15 57.0 0.0 3e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Popeye PF04831.13 CDI75563.1 - 1.6e-11 44.5 0.0 2.5e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Popeye protein conserved region cNMP_binding PF00027.29 CDI75563.1 - 0.00082 19.4 0.5 0.035 14.2 0.0 2.6 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain SR-25 PF10500.9 CDI75565.1 - 0.0049 16.5 24.2 0.0049 16.5 24.2 4.4 4 0 0 4 4 4 3 Nuclear RNA-splicing-associated protein ASH PF15780.5 CDI75565.1 - 0.0075 16.4 0.1 0.038 14.2 0.0 2.3 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Serinc PF03348.15 CDI75565.1 - 3.3 6.5 8.2 7.2 5.4 8.2 1.6 1 0 0 1 1 1 0 Serine incorporator (Serinc) Glyco_hydro_9 PF00759.19 CDI75566.1 - 0.032 13.7 0.2 0.032 13.7 0.2 9.2 2 2 4 7 7 7 0 Glycosyl hydrolase family 9 EFG_II PF14492.6 CDI75567.1 - 6.2e-14 51.8 0.0 1.2e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 CDI75567.1 - 0.0042 16.8 0.1 0.014 15.2 0.1 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV Peptidase_C3 PF00548.20 CDI75567.1 - 0.11 12.4 0.1 0.18 11.7 0.1 1.2 1 0 0 1 1 1 0 3C cysteine protease (picornain 3C) Presenilin PF01080.17 CDI75567.1 - 0.41 9.4 10.8 0.65 8.7 10.8 1.2 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 CDI75567.1 - 0.95 8.2 13.7 1.3 7.8 13.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain BAF1_ABF1 PF04684.13 CDI75567.1 - 4.9 6.1 19.7 0.77 8.7 16.2 1.4 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Macoilin PF09726.9 CDI75567.1 - 7.8 4.9 20.9 13 4.2 20.9 1.3 1 0 0 1 1 1 0 Macoilin family Shadoo PF14999.6 CDI75567.1 - 8.2 6.5 15.2 0.74 9.9 9.5 2.0 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective RBFA PF02033.18 CDI75569.1 - 0.00017 22.0 0.2 0.00077 19.9 0.0 2.2 1 1 0 1 1 1 1 Ribosome-binding factor A DUF2722 PF10846.8 CDI75569.1 - 0.0003 19.9 9.8 0.0003 19.9 9.8 4.2 3 1 1 4 4 4 2 Protein of unknown function (DUF2722) RskA PF10099.9 CDI75569.1 - 0.00039 20.8 8.4 0.00039 20.8 8.4 4.7 3 1 1 4 4 4 3 Anti-sigma-K factor rskA Scs3p PF10261.9 CDI75569.1 - 0.0098 15.4 0.2 0.0098 15.4 0.2 3.3 3 0 0 3 3 3 1 Inositol phospholipid synthesis and fat-storage-inducing TM Dehydrin PF00257.19 CDI75569.1 - 0.016 15.8 3.1 0.016 15.8 3.1 5.2 4 1 0 5 5 5 0 Dehydrin Orf78 PF06024.12 CDI75569.1 - 0.16 12.3 0.3 0.16 12.3 0.3 4.5 5 0 0 5 5 5 0 Orf78 (ac78) Tim54 PF11711.8 CDI75570.1 - 0.13 11.0 22.6 0.15 10.8 22.6 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF3818 PF12825.7 CDI75570.1 - 0.13 11.2 0.5 0.27 10.2 0.5 1.5 1 1 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) Dirigent PF03018.14 CDI75570.1 - 0.26 11.1 3.2 0.31 10.8 2.9 1.4 1 1 0 1 1 1 0 Dirigent-like protein Afi1 PF07792.12 CDI75570.1 - 2 8.9 13.9 2.7 8.5 5.0 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PNISR PF15996.5 CDI75570.1 - 2.1 8.6 27.1 2.5 8.3 27.1 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR BUD22 PF09073.10 CDI75570.1 - 3 7.1 29.8 4.1 6.7 29.8 1.2 1 0 0 1 1 1 0 BUD22 Caldesmon PF02029.15 CDI75570.1 - 6.8 5.3 34.3 8.5 5.0 34.3 1.1 1 0 0 1 1 1 0 Caldesmon SAPS PF04499.15 CDI75570.1 - 8.6 5.0 14.4 11 4.7 14.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Surp PF01805.20 CDI75571.1 - 0.036 14.1 0.0 0.082 12.9 0.0 1.6 1 0 0 1 1 1 0 Surp module Scs3p PF10261.9 CDI75571.1 - 0.87 9.0 5.3 1.1 8.7 5.3 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Presenilin PF01080.17 CDI75571.1 - 3.1 6.5 9.6 3.6 6.3 9.6 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI75571.1 - 5.1 7.1 9.3 6.5 6.7 9.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AF-4 PF05110.13 CDI75571.1 - 5.6 4.9 17.7 5.8 4.9 17.7 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PAT1 PF09770.9 CDI75571.1 - 6.2 5.0 26.3 6.7 4.8 26.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FAM199X PF15814.5 CDI75572.1 - 0.0082 15.2 19.0 0.0082 15.2 19.0 2.1 2 0 0 2 2 2 1 Protein family FAM199X CTD_bind PF04818.13 CDI75572.1 - 0.017 15.9 3.8 1.4 9.8 0.2 2.8 1 1 1 2 2 2 0 RNA polymerase II-binding domain. POX PF07526.11 CDI75572.1 - 0.095 13.3 11.8 0.036 14.6 5.1 2.2 2 0 0 2 2 2 0 Associated with HOX MID_MedPIWI PF18296.1 CDI75572.1 - 0.26 11.0 8.8 0.14 11.9 4.2 2.2 2 0 0 2 2 2 0 MID domain of medPIWI Apt1 PF10351.9 CDI75572.1 - 0.29 9.9 20.6 0.024 13.5 8.4 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDI75572.1 - 0.64 8.5 21.1 0.01 14.5 10.4 2.1 2 0 0 2 2 2 0 Macoilin family Pol_alpha_B_N PF08418.10 CDI75572.1 - 0.91 9.4 10.0 6.2 6.7 4.1 2.3 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal CCDC106 PF15794.5 CDI75572.1 - 0.96 9.1 21.9 0.056 13.2 8.9 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 RAP1 PF07218.11 CDI75572.1 - 1 7.5 26.6 0.081 11.2 18.1 2.0 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) Ctr PF04145.15 CDI75572.1 - 1.1 9.9 9.1 2.2 8.9 1.2 2.3 2 0 0 2 2 2 0 Ctr copper transporter family RP-C_C PF11800.8 CDI75572.1 - 2.2 8.3 7.9 4.4 7.3 1.4 2.2 2 0 0 2 2 2 0 Replication protein C C-terminal region CCDC24 PF15669.5 CDI75572.1 - 3.9 7.3 16.4 0.45 10.3 7.8 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family Miga PF10265.9 CDI75572.1 - 4.7 6.1 17.0 0.3 10.0 9.9 1.9 2 0 0 2 2 2 0 Mitoguardin ASD2 PF08687.11 CDI75572.1 - 4.7 6.7 7.8 3.2 7.2 2.5 2.1 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Peroxin-3 PF04882.12 CDI75572.1 - 4.7 6.1 13.5 0.86 8.5 7.2 2.0 2 0 0 2 2 2 0 Peroxin-3 Pannexin_like PF12534.8 CDI75572.1 - 6.3 5.8 9.6 0.085 11.9 1.9 1.6 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 Tmemb_cc2 PF10267.9 CDI75572.1 - 6.8 5.7 12.6 1.2 8.2 6.7 2.1 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein TraV PF09676.10 CDI75572.1 - 8.3 7.4 9.4 1.6 9.8 1.9 2.4 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) DUF4614 PF15391.6 CDI75572.1 - 9.3 6.2 35.3 1.3 9.0 17.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4614) Med3 PF11593.8 CDI75573.1 - 0.0011 18.3 14.6 0.0011 18.3 14.6 7.0 3 1 1 5 5 5 1 Mediator complex subunit 3 fungal ApoO PF09769.9 CDI75573.1 - 0.57 10.1 5.0 2.3 8.2 1.4 2.7 2 0 0 2 2 2 0 Apolipoprotein O BAF1_ABF1 PF04684.13 CDI75574.1 - 0.0049 16.0 26.6 0.0068 15.5 26.6 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor Macoilin PF09726.9 CDI75574.1 - 0.052 12.1 41.4 0.062 11.9 41.4 1.1 1 0 0 1 1 1 0 Macoilin family Plasmodium_Vir PF05795.11 CDI75574.1 - 0.13 11.7 18.3 0.17 11.3 18.3 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF4407 PF14362.6 CDI75574.1 - 2.5 7.4 25.4 3.6 6.9 25.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mucin PF01456.17 CDI75574.1 - 3.3 7.7 13.5 4.7 7.2 13.5 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Spc7_N PF15402.6 CDI75574.1 - 9.5 4.3 38.7 11 4.1 38.7 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 PI3K_1B_p101 PF10486.9 CDI75574.1 - 9.7 3.8 24.2 13 3.4 24.2 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RskA PF10099.9 CDI75575.1 - 9.7e-05 22.7 6.7 9.7e-05 22.7 6.7 4.1 1 1 3 4 4 4 1 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI75577.1 - 0.0051 15.8 50.0 0.0051 15.8 50.0 3.3 2 1 1 3 3 3 1 Transcriptional activator LAG-3 TCP PF03634.13 CDI75577.1 - 0.007 16.9 8.3 0.007 16.9 8.3 2.3 2 0 0 2 2 2 1 TCP family transcription factor RskA PF10099.9 CDI75577.1 - 0.0073 16.6 19.3 0.0073 16.6 19.3 4.9 1 1 2 3 3 3 1 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI75577.1 - 0.18 10.6 56.4 0.13 11.0 15.5 2.1 2 0 0 2 2 2 0 Presenilin DUF572 PF04502.13 CDI75577.1 - 9.5 5.7 43.3 15 5.1 43.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) HMG_box PF00505.19 CDI75578.1 - 8.5e-17 61.3 4.9 2.6e-16 59.8 4.9 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDI75578.1 - 6.8e-06 26.6 6.7 6.8e-06 26.6 6.7 2.0 1 1 0 1 1 1 1 HMG-box domain DUF4407 PF14362.6 CDI75578.1 - 0.61 9.4 13.1 1 8.7 13.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ARGLU PF15346.6 CDI75578.1 - 2.3 8.1 16.5 0.13 12.1 8.0 2.4 2 1 0 2 2 2 0 Arginine and glutamate-rich 1 ubiquitin PF00240.23 CDI75579.1 - 2.4e-61 203.4 5.1 2.1e-34 117.1 0.3 2.6 2 1 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 CDI75579.1 - 6.8e-29 99.5 4.6 2.8e-16 59.1 0.4 2.6 2 1 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CDI75579.1 - 2e-08 34.6 0.3 3.8e-05 24.1 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CDI75579.1 - 7e-07 29.3 0.0 0.025 14.7 0.0 2.5 2 1 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 CDI75579.1 - 2.5e-06 27.8 0.1 0.019 15.3 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 CDI75579.1 - 1.2e-05 25.1 0.1 0.0058 16.5 0.0 2.3 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 CDI75579.1 - 7.1e-05 23.3 0.0 0.12 12.9 0.0 2.2 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 CDI75579.1 - 0.00033 20.7 3.6 8.4 6.5 0.0 3.8 3 1 1 4 4 4 3 Ubiquitin-like domain HATPase_c PF02518.26 CDI75579.1 - 0.00078 19.9 0.7 1.2 9.7 0.1 2.2 1 1 1 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2870 PF11069.8 CDI75579.1 - 0.015 15.7 0.0 10 6.6 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2870) Sde2_N_Ubi PF13019.6 CDI75579.1 - 0.033 14.0 0.1 0.85 9.4 0.0 2.4 1 1 1 2 2 2 0 Silencing defective 2 N-terminal ubiquitin domain UDP-g_GGTase PF06427.11 CDI75579.1 - 0.16 12.1 0.2 1.8 8.7 0.0 2.3 3 0 0 3 3 3 0 UDP-glucose:Glycoprotein Glucosyltransferase FERM_f0 PF16511.5 CDI75579.1 - 0.16 12.3 0.5 30 5.0 0.2 2.9 2 1 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM MS_channel PF00924.18 CDI75580.1 - 1e-18 67.6 1.4 1.5e-18 67.1 1.4 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel EOS1 PF12326.8 CDI75580.1 - 0.0071 16.3 1.9 0.0071 16.3 1.9 3.6 3 1 0 3 3 3 1 N-glycosylation protein DUF2393 PF09624.10 CDI75580.1 - 3.8 7.5 6.5 2 8.4 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) TIM PF00121.18 CDI75581.1 - 4.5e-88 294.7 1.5 5.1e-88 294.5 1.5 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase DUF1802 PF08819.11 CDI75581.1 - 0.067 13.0 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1802) Ribonucleas_3_3 PF14622.6 CDI75581.1 - 0.11 12.6 0.3 0.26 11.5 0.2 1.5 1 1 0 1 1 1 0 Ribonuclease-III-like Kinesin PF00225.23 CDI75582.1 - 1.7e-90 303.3 0.1 2.7e-90 302.7 0.1 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDI75582.1 - 7.3e-23 81.1 0.0 1.8e-22 79.9 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding LMBR1 PF04791.16 CDI75582.1 - 0.65 8.8 3.7 1.2 7.9 3.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein TolA_bind_tri PF16331.5 CDI75582.1 - 4.7 7.3 8.3 6.5 6.9 0.3 3.5 3 0 0 3 3 3 0 TolA binding protein trimerisation PI3K_1B_p101 PF10486.9 CDI75583.1 - 0.0061 14.4 10.8 0.0069 14.2 10.8 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit FAM60A PF15396.6 CDI75583.1 - 0.0092 16.0 14.6 0.012 15.6 14.6 1.1 1 0 0 1 1 1 1 Protein Family FAM60A CD20 PF04103.15 CDI75583.1 - 0.023 14.8 1.8 0.023 14.8 1.8 1.9 1 1 1 2 2 2 0 CD20-like family TMEM223 PF14640.6 CDI75583.1 - 0.025 14.8 3.3 0.24 11.6 0.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 223 SLATT_1 PF18181.1 CDI75583.1 - 0.055 13.4 16.3 0.078 12.9 16.3 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 BAF1_ABF1 PF04684.13 CDI75583.1 - 0.076 12.1 24.8 0.097 11.7 24.8 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Presenilin PF01080.17 CDI75583.1 - 0.097 11.4 22.1 0.12 11.1 22.1 1.1 1 0 0 1 1 1 0 Presenilin RskA PF10099.9 CDI75583.1 - 0.12 12.7 33.3 33 4.7 33.5 2.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI75583.1 - 0.12 11.9 28.5 0.22 11.1 28.5 1.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Smg8_Smg9 PF10220.9 CDI75583.1 - 0.18 10.0 16.8 0.22 9.8 16.9 1.0 1 0 0 1 1 1 0 Smg8_Smg9 CcmF_C PF16327.5 CDI75583.1 - 0.25 10.6 2.5 0.32 10.2 2.5 1.1 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal DUF5523 PF17661.1 CDI75583.1 - 0.35 10.5 13.0 0.51 10.0 13.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) SLC12 PF03522.15 CDI75583.1 - 0.82 8.6 18.4 0.97 8.4 18.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4366 PF14283.6 CDI75583.1 - 0.84 9.7 10.5 2.1 8.4 1.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) LAP1C PF05609.12 CDI75583.1 - 0.96 8.5 21.7 1.1 8.2 21.7 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF5427 PF10310.9 CDI75583.1 - 0.96 8.3 26.1 1.2 8.0 26.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SID-1_RNA_chan PF13965.6 CDI75583.1 - 2.4 6.5 5.5 3 6.1 5.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Apt1 PF10351.9 CDI75583.1 - 2.7 6.8 14.1 2.9 6.6 14.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Pam17 PF08566.10 CDI75583.1 - 2.7 7.8 14.1 2.4 8.0 2.0 2.1 1 1 1 2 2 2 0 Mitochondrial import protein Pam17 Sin_N PF04801.13 CDI75583.1 - 3.2 6.8 29.8 3.7 6.7 29.8 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Ndc1_Nup PF09531.10 CDI75583.1 - 3.7 6.1 25.6 4.2 5.9 25.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4770 PF15994.5 CDI75583.1 - 3.8 7.7 17.4 0.8 9.9 3.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) NPR3 PF03666.13 CDI75583.1 - 3.9 6.2 19.1 5.5 5.7 19.1 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Consortin_C PF15281.6 CDI75583.1 - 4.2 7.4 6.2 15 5.6 1.6 2.1 2 0 0 2 2 2 0 Consortin C-terminus CAML PF14963.6 CDI75583.1 - 5.4 7.1 13.4 6.9 6.7 13.4 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand DUF4179 PF13786.6 CDI75583.1 - 5.9 7.4 8.9 1 9.8 5.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4179) GREB1 PF15782.5 CDI75583.1 - 6.1 3.8 23.3 7.4 3.5 23.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Serinc PF03348.15 CDI75583.1 - 7.5 5.4 15.8 11 4.8 15.7 1.3 1 1 0 1 1 1 0 Serine incorporator (Serinc) Raftlin PF15250.6 CDI75583.1 - 7.8 5.1 17.0 9.6 4.8 17.0 1.1 1 0 0 1 1 1 0 Raftlin DUF2052 PF09747.9 CDI75583.1 - 9.2 6.3 18.1 16 5.6 18.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) ALMT PF11744.8 CDI75583.1 - 9.5 4.9 15.2 14 4.4 15.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2116 PF09889.9 CDI75584.1 - 0.76 9.8 3.3 17 5.5 0.5 2.5 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF3138 PF11336.8 CDI75585.1 - 0.002 16.9 11.2 0.0021 16.8 11.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3138) TMF_DNA_bd PF12329.8 CDI75585.1 - 0.0033 17.4 6.2 0.26 11.3 0.1 2.1 2 0 0 2 2 2 2 TATA element modulatory factor 1 DNA binding BST2 PF16716.5 CDI75585.1 - 0.021 15.4 10.0 0.073 13.7 10.0 1.7 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 Baculo_p24 PF05073.12 CDI75585.1 - 0.039 13.7 0.4 0.29 10.9 0.4 1.9 1 1 0 1 1 1 0 Baculovirus P24 capsid protein AAA_23 PF13476.6 CDI75585.1 - 0.053 14.0 0.6 0.063 13.8 0.6 1.1 1 0 0 1 1 1 0 AAA domain DUF3006 PF11213.8 CDI75585.1 - 0.061 13.6 1.1 6.3 7.1 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3006) PKcGMP_CC PF16808.5 CDI75585.1 - 0.072 13.0 5.2 1.4 8.8 1.4 2.2 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Lzipper-MIP1 PF14389.6 CDI75585.1 - 0.087 13.1 6.4 0.24 11.7 6.4 1.7 1 1 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 Ribosomal_60s PF00428.19 CDI75585.1 - 0.21 12.2 22.0 0.32 11.6 22.0 1.4 1 1 0 1 1 1 0 60s Acidic ribosomal protein PSI_PsaF PF02507.15 CDI75585.1 - 0.22 11.4 3.2 0.26 11.1 3.2 1.2 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III UPF0565 PF10561.9 CDI75585.1 - 0.3 10.2 1.7 0.31 10.2 1.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 FUSC PF04632.12 CDI75585.1 - 0.37 9.3 10.8 0.4 9.1 10.8 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DSBA PF01323.20 CDI75585.1 - 0.61 9.8 5.8 0.66 9.7 5.8 1.0 1 0 0 1 1 1 0 DSBA-like thioredoxin domain DUF3824 PF12868.7 CDI75585.1 - 6.7 7.4 12.6 10 6.7 12.6 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) SMC_N PF02463.19 CDI75586.1 - 4.2e-08 32.9 3.1 4.2e-08 32.9 3.1 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDI75586.1 - 3.2e-05 23.9 0.0 4.3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CDI75586.1 - 6.7e-05 22.8 0.6 0.00045 20.0 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain Presenilin PF01080.17 CDI75586.1 - 0.31 9.8 5.5 0.41 9.3 5.5 1.1 1 0 0 1 1 1 0 Presenilin SR-25 PF10500.9 CDI75586.1 - 0.8 9.3 15.5 0.11 12.1 7.2 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4207 PF13904.6 CDI75586.1 - 1.1 8.9 17.8 0.1 12.3 11.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) SbcCD_C PF13558.6 CDI75586.1 - 3.1 8.1 7.3 0.52 10.6 2.1 2.3 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Plasmodium_Vir PF05795.11 CDI75586.1 - 5.7 6.2 7.4 1.8 7.9 3.2 1.8 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Roughex PF06020.11 CDI75586.1 - 8.4 5.4 9.3 11 4.9 9.3 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Condensin2nSMC PF12422.8 CDI75587.1 - 0.2 11.9 4.6 0.44 10.7 4.6 1.6 1 1 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit FRB_dom PF08771.11 CDI75587.1 - 1.4 9.3 12.5 0.2 12.1 3.1 2.7 2 1 0 2 2 2 0 FKBP12-rapamycin binding domain Ribosomal_S30AE PF02482.19 CDI75587.1 - 1.9 9.3 6.9 5.3 7.9 4.4 2.7 1 1 1 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein AbLIM_anchor PF16182.5 CDI75588.1 - 0.027 14.3 19.6 0.031 14.1 19.6 1.2 1 0 0 1 1 1 0 Putative adherens-junction anchoring region of AbLIM PPP4R2 PF09184.11 CDI75588.1 - 0.75 9.3 16.2 0.88 9.1 16.2 1.2 1 0 0 1 1 1 0 PPP4R2 Peptidase_S64 PF08192.11 CDI75588.1 - 6.9 5.0 26.6 8.2 4.8 26.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 RskA PF10099.9 CDI75590.1 - 0.074 13.3 0.1 0.074 13.3 0.1 12.1 7 4 3 10 10 10 0 Anti-sigma-K factor rskA DUF4667 PF15700.5 CDI75591.1 - 0.00029 21.0 8.1 0.00029 21.0 8.1 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4667) SARAF PF06682.12 CDI75591.1 - 0.0017 18.0 14.8 0.0017 18.0 14.8 3.8 2 1 0 3 3 3 1 SOCE-associated regulatory factor of calcium homoeostasis OmpH PF03938.14 CDI75591.1 - 0.0062 16.9 13.2 0.0062 16.9 13.2 4.1 4 0 0 4 4 4 1 Outer membrane protein (OmpH-like) DivIC PF04977.15 CDI75591.1 - 0.015 15.0 6.1 0.015 15.0 6.1 4.3 4 0 0 4 4 4 0 Septum formation initiator SRP9-21 PF05486.12 CDI75591.1 - 0.027 14.9 0.4 0.027 14.9 0.4 5.2 3 1 2 5 5 5 0 Signal recognition particle 9 kDa protein (SRP9) N6_N4_Mtase PF01555.18 CDI75591.1 - 0.037 13.7 0.0 0.51 10.0 0.0 2.7 2 1 0 2 2 2 0 DNA methylase Hist_deacetyl PF00850.19 CDI75591.1 - 0.3 10.5 10.5 3.3 7.1 5.0 2.6 1 1 0 2 2 2 0 Histone deacetylase domain Cupin_6 PF12852.7 CDI75591.1 - 0.34 10.6 0.0 0.34 10.6 0.0 2.9 2 1 1 3 3 3 0 Cupin SpoIIP PF07454.11 CDI75591.1 - 0.45 9.9 34.2 0.069 12.6 2.6 4.2 4 0 0 4 4 4 0 Stage II sporulation protein P (SpoIIP) TCP PF03634.13 CDI75591.1 - 0.99 10.0 48.7 0.68 10.5 11.0 4.1 4 0 0 4 4 4 0 TCP family transcription factor Cation_ATPase PF13246.6 CDI75591.1 - 1.4 9.0 4.7 0.54 10.4 0.7 2.3 2 0 0 2 2 2 0 Cation transport ATPase (P-type) RuvC_III PF18541.1 CDI75591.1 - 1.6 8.6 34.5 0.073 13.0 2.9 3.7 4 0 0 4 4 4 0 RuvC endonuclease subdomain 3 RskA PF10099.9 CDI75592.1 - 3.6e-10 40.4 28.1 9.4e-07 29.3 6.0 3.1 1 1 1 2 2 2 2 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI75592.1 - 0.037 13.6 65.9 2 8.0 39.0 2.9 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein PBP PF01161.20 CDI75593.1 - 0.00015 22.1 0.0 0.00023 21.5 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Ecm29 PF13001.7 CDI75594.1 - 3.7e-14 52.3 4.0 1.8e-08 33.5 2.0 2.9 2 0 0 2 2 2 2 Proteasome stabiliser Ipi1_N PF12333.8 CDI75594.1 - 0.017 15.7 4.7 0.8 10.3 0.0 5.3 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation HEAT PF02985.22 CDI75594.1 - 0.037 14.3 0.1 0.037 14.3 0.1 5.0 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.6 CDI75594.1 - 0.054 14.0 0.0 0.054 14.0 0.0 6.5 7 0 0 7 7 7 0 HEAT-like repeat Cohesin_HEAT PF12765.7 CDI75594.1 - 0.06 13.7 0.1 0.15 12.4 0.1 1.7 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion YABBY PF04690.13 CDI75595.1 - 0.054 14.1 5.4 0.065 13.8 5.4 1.2 1 0 0 1 1 1 0 YABBY protein zf-HIT PF04438.16 CDI75595.1 - 0.069 13.0 6.2 0.15 12.0 6.2 1.6 1 0 0 1 1 1 0 HIT zinc finger Spt20 PF12090.8 CDI75595.1 - 0.12 12.0 13.1 0.13 11.8 13.1 1.2 1 0 0 1 1 1 0 Spt20 family TERB2 PF15101.6 CDI75595.1 - 0.42 10.6 7.7 0.5 10.4 7.7 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 LAP1C PF05609.12 CDI75595.1 - 1.2 8.1 12.4 1.4 7.9 12.4 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) NPR3 PF03666.13 CDI75595.1 - 2.1 7.0 9.7 2.1 7.0 9.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ALMT PF11744.8 CDI75595.1 - 3.4 6.4 5.4 3.7 6.3 5.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Connexin PF00029.19 CDI75595.1 - 3.8 7.2 8.6 4.4 7.0 8.6 1.3 1 0 0 1 1 1 0 Connexin RR_TM4-6 PF06459.12 CDI75595.1 - 4.5 7.0 13.6 6.2 6.6 13.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI75595.1 - 5.2 6.0 9.3 5.5 5.9 9.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 CDI75595.1 - 5.7 5.6 14.2 6.4 5.4 14.2 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 CDI75595.1 - 7.5 4.7 12.7 8.4 4.5 12.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DTW PF03942.15 CDI75596.1 - 5e-21 75.3 0.6 1.1e-20 74.2 0.6 1.6 1 0 0 1 1 1 1 DTW domain Spt20 PF12090.8 CDI75596.1 - 0.00016 21.3 28.9 0.0035 17.0 7.4 2.3 2 0 0 2 2 2 2 Spt20 family Presenilin PF01080.17 CDI75596.1 - 0.53 9.0 21.1 0.66 8.7 3.0 2.1 2 0 0 2 2 2 0 Presenilin EMC3_TMCO1 PF01956.16 CDI75596.1 - 0.76 9.5 0.0 0.76 9.5 0.0 2.5 3 0 0 3 3 3 0 Integral membrane protein EMC3/TMCO1-like Suf PF05843.14 CDI75596.1 - 2.1 8.3 18.9 2 8.3 8.2 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Zip PF02535.22 CDI75596.1 - 4.2 6.5 9.5 7.9 5.6 0.3 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter TFIIA PF03153.13 CDI75596.1 - 7.2 6.5 39.4 2.6 8.0 13.1 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit TcpE PF12648.7 CDI75597.1 - 0.0064 17.0 1.4 0.013 16.0 1.4 1.5 1 0 0 1 1 1 1 TcpE family EXS PF03124.14 CDI75597.1 - 0.014 14.8 0.9 0.016 14.5 0.9 1.1 1 0 0 1 1 1 0 EXS family DUF92 PF01940.16 CDI75597.1 - 0.026 13.9 2.1 0.038 13.4 2.1 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF92 DUF1700 PF08006.11 CDI75597.1 - 0.075 12.6 0.3 0.11 12.1 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Flavi_NS4A PF01350.17 CDI75597.1 - 0.077 12.9 1.8 0.13 12.2 1.8 1.3 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4A Sdh_cyt PF01127.22 CDI75597.1 - 0.1 12.6 7.6 0.16 12.0 7.6 1.2 1 0 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF677 PF05055.12 CDI75597.1 - 1.7 7.4 4.5 3.8 6.3 4.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF677) TFIIA PF03153.13 CDI75598.1 - 4.4e-05 23.7 21.0 6.5e-05 23.1 21.0 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit ANAPC4_WD40 PF12894.7 CDI75598.1 - 0.0002 21.6 0.1 4.2 7.7 0.0 4.4 5 0 0 5 5 4 1 Anaphase-promoting complex subunit 4 WD40 domain SR-25 PF10500.9 CDI75598.1 - 0.00036 20.2 28.7 0.0089 15.7 17.7 2.3 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI75598.1 - 0.00086 19.6 0.0 0.0022 18.3 0.0 1.6 1 1 0 1 1 1 1 Anti-sigma-K factor rskA WD40_like PF17005.5 CDI75598.1 - 0.0051 16.2 0.0 0.12 11.6 0.0 2.5 1 1 2 3 3 3 1 WD40-like domain Cwf_Cwc_15 PF04889.12 CDI75598.1 - 0.0078 16.0 25.8 0.015 15.1 25.8 1.4 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein IMUP PF15761.5 CDI75598.1 - 0.0089 16.7 24.1 0.065 13.9 8.3 2.6 2 0 0 2 2 2 2 Immortalisation up-regulated protein GREB1 PF15782.5 CDI75598.1 - 0.016 12.4 12.1 0.019 12.1 12.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CNDH2_C PF16858.5 CDI75598.1 - 0.02 14.8 15.2 0.03 14.2 15.2 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Nop25 PF09805.9 CDI75598.1 - 0.025 15.1 20.6 0.046 14.2 20.6 1.4 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) BUD22 PF09073.10 CDI75598.1 - 0.026 13.9 23.2 0.036 13.4 23.2 1.1 1 0 0 1 1 1 0 BUD22 WD40 PF00400.32 CDI75598.1 - 0.054 14.4 5.1 8.7 7.4 0.1 4.7 5 1 1 6 6 4 0 WD domain, G-beta repeat DNA_pol_phi PF04931.13 CDI75598.1 - 0.061 11.4 19.1 0.094 10.8 19.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi MDM1 PF15501.6 CDI75598.1 - 0.14 11.3 23.4 0.19 10.8 23.4 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 Nha1_C PF08619.10 CDI75598.1 - 0.18 11.0 25.6 0.26 10.4 25.6 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Band_3_cyto PF07565.13 CDI75598.1 - 0.24 11.2 13.5 0.36 10.6 13.5 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Exonuc_VII_L PF02601.15 CDI75598.1 - 0.35 10.4 11.2 0.52 9.8 11.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Apt1 PF10351.9 CDI75598.1 - 0.43 9.4 20.3 0.59 8.9 20.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain PepSY_TM PF03929.16 CDI75598.1 - 0.45 10.1 1.2 0.67 9.6 1.2 1.3 1 0 0 1 1 1 0 PepSY-associated TM region Spt20 PF12090.8 CDI75598.1 - 0.56 9.8 37.1 1.1 8.8 37.1 1.5 1 0 0 1 1 1 0 Spt20 family Baculo_PP31 PF05311.11 CDI75598.1 - 0.56 9.6 12.9 1.1 8.7 12.9 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF913 PF06025.12 CDI75598.1 - 0.73 8.8 9.0 1.4 7.9 9.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SLC12 PF03522.15 CDI75598.1 - 0.87 8.5 15.9 1.2 8.1 15.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 NARP1 PF12569.8 CDI75598.1 - 0.91 8.4 14.6 1.3 7.8 14.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Pet20 PF08692.10 CDI75598.1 - 1.7 9.4 5.3 11 6.7 2.8 2.5 2 0 0 2 2 2 0 Mitochondrial protein Pet20 RAP1 PF07218.11 CDI75598.1 - 2 6.6 8.2 2.7 6.2 8.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Smg8_Smg9 PF10220.9 CDI75598.1 - 2.3 6.4 18.7 3.1 6.0 18.7 1.2 1 0 0 1 1 1 0 Smg8_Smg9 DUF4407 PF14362.6 CDI75598.1 - 2.3 7.5 10.6 3.8 6.8 10.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4746 PF15928.5 CDI75598.1 - 3.4 7.0 11.4 5.6 6.3 11.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Serinc PF03348.15 CDI75598.1 - 3.4 6.5 4.7 4.8 6.0 4.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Neur_chan_memb PF02932.16 CDI75598.1 - 4 7.4 11.2 6.3 6.8 11.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SPX PF03105.19 CDI75598.1 - 4.7 7.0 26.7 6.5 6.6 26.7 1.1 1 0 0 1 1 1 0 SPX domain Connexin PF00029.19 CDI75598.1 - 6.9 6.4 9.1 14 5.4 9.1 1.5 1 0 0 1 1 1 0 Connexin SID-1_RNA_chan PF13965.6 CDI75598.1 - 8.2 4.7 5.2 11 4.3 5.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EPL1 PF10513.9 CDI75599.1 - 0.015 15.7 18.6 0.015 15.7 18.6 2.1 1 1 1 2 2 2 0 Enhancer of polycomb-like Sin_N PF04801.13 CDI75599.1 - 0.053 12.7 31.5 0.21 10.8 22.8 2.0 2 0 0 2 2 2 0 Sin-like protein conserved region Nop53 PF07767.11 CDI75599.1 - 0.059 12.8 31.1 0.079 12.3 31.1 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SelP_N PF04592.14 CDI75599.1 - 0.086 12.2 37.3 0.44 9.9 3.3 2.1 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Exonuc_VII_L PF02601.15 CDI75599.1 - 0.15 11.6 25.2 0.22 11.1 25.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2052 PF09747.9 CDI75599.1 - 0.2 11.8 26.2 0.92 9.6 19.5 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) TRAP_alpha PF03896.16 CDI75599.1 - 0.21 10.8 6.8 0.32 10.2 3.4 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Sec62 PF03839.16 CDI75599.1 - 0.25 10.8 18.5 0.54 9.7 11.6 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 Sec16 PF12932.7 CDI75599.1 - 0.27 11.9 0.2 0.27 11.9 0.2 3.1 2 1 0 2 2 1 0 Vesicle coat trafficking protein Sec16 mid-region DUF5523 PF17661.1 CDI75599.1 - 0.27 10.9 22.4 4.3 7.0 17.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) TCP PF03634.13 CDI75599.1 - 0.58 10.7 25.9 2.8 8.5 17.5 2.2 2 0 0 2 2 2 0 TCP family transcription factor PNISR PF15996.5 CDI75599.1 - 0.69 10.1 30.0 2.5 8.3 22.1 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR CobT PF06213.12 CDI75599.1 - 0.77 9.1 33.0 0.48 9.8 22.1 2.3 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Slu7 PF11708.8 CDI75599.1 - 0.8 9.4 24.0 0.95 9.2 17.1 2.1 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor PPL5 PF18168.1 CDI75599.1 - 1.1 8.5 14.2 0.51 9.6 7.7 2.1 2 0 0 2 2 2 0 Prim-pol family 5 CDC45 PF02724.14 CDI75599.1 - 1.1 7.4 19.2 0.18 10.0 12.5 2.0 2 0 0 2 2 2 0 CDC45-like protein Otopetrin PF03189.13 CDI75599.1 - 1.2 7.9 14.6 3 6.6 0.2 2.1 2 0 0 2 2 2 0 Otopetrin Vac7 PF12751.7 CDI75599.1 - 1.8 8.0 15.3 0.88 8.9 6.2 2.1 2 0 0 2 2 2 0 Vacuolar segregation subunit 7 Tim54 PF11711.8 CDI75599.1 - 2.6 6.7 20.7 1.4 7.6 13.6 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 NPR3 PF03666.13 CDI75599.1 - 2.8 6.6 21.7 1.1 8.0 15.6 2.0 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_S64 PF08192.11 CDI75599.1 - 2.9 6.3 22.8 0.71 8.3 16.6 1.9 2 0 0 2 2 2 0 Peptidase family S64 RP-C_C PF11800.8 CDI75599.1 - 3.8 7.6 20.8 4.9 7.2 15.0 2.2 2 0 0 2 2 2 0 Replication protein C C-terminal region FAM60A PF15396.6 CDI75599.1 - 3.9 7.4 20.6 6.5 6.7 14.3 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Spore_coat_CotO PF14153.6 CDI75599.1 - 3.9 7.4 36.5 1.6 8.6 24.0 2.2 2 0 0 2 2 2 0 Spore coat protein CotO DUF4638 PF15472.6 CDI75599.1 - 4.6 6.9 17.9 3.6 7.3 12.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) DUF4271 PF14093.6 CDI75600.1 - 0.62 9.9 5.0 1.4 8.7 5.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) Ninjurin PF04923.12 CDI75600.1 - 0.95 9.4 9.4 2.8 7.9 9.4 1.8 1 0 0 1 1 1 0 Ninjurin DUF4820 PF16091.5 CDI75601.1 - 0.0074 15.7 4.9 0.0074 15.7 4.9 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4820) MelC1 PF06236.11 CDI75601.1 - 0.04 14.0 20.1 0.078 13.1 3.6 2.3 2 0 0 2 2 2 0 Tyrosinase co-factor MelC1 ATP_transf PF09830.9 CDI75601.1 - 0.57 10.4 0.1 0.57 10.4 0.1 2.5 2 0 0 2 2 2 0 ATP adenylyltransferase Med15 PF09606.10 CDI75601.1 - 2.1 6.9 38.7 2.3 6.8 7.8 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF1772 PF08592.11 CDI75601.1 - 2.7 8.3 15.6 7.9 6.8 2.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) RIFIN PF02009.16 CDI75601.1 - 3.7 7.3 17.8 1.4 8.8 6.5 2.3 2 0 0 2 2 2 0 Rifin Connexin PF00029.19 CDI75601.1 - 4.8 6.9 7.6 2.3 7.9 3.7 2.1 2 0 0 2 2 2 0 Connexin DUF1761 PF08570.10 CDI75601.1 - 7.5 6.8 10.9 0.3 11.3 4.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1761) Presenilin PF01080.17 CDI75601.1 - 8.3 5.1 14.5 5.5 5.6 11.1 2.0 2 0 0 2 2 2 0 Presenilin TFIIA PF03153.13 CDI75602.1 - 1.8e-06 28.2 26.6 1.8e-06 28.2 26.6 3.5 2 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Peptidase_S49_N PF08496.10 CDI75602.1 - 0.0038 17.3 6.2 0.0038 17.3 6.2 3.5 3 0 0 3 3 3 1 Peptidase family S49 N-terminal DUF4746 PF15928.5 CDI75602.1 - 0.0081 15.6 3.4 0.0081 15.6 3.4 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4746) CNDH2_C PF16858.5 CDI75602.1 - 1.6 8.5 27.3 0.2 11.5 10.7 3.2 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF4834 PF16118.5 CDI75602.1 - 3.1 8.8 39.3 2.9 8.9 0.2 5.4 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) Sin_N PF04801.13 CDI75602.1 - 5.3 6.1 45.4 0.012 14.9 17.4 3.7 4 0 0 4 4 4 0 Sin-like protein conserved region Tim54 PF11711.8 CDI75603.1 - 6.1 5.5 27.3 6 5.6 27.3 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 CDI75603.1 - 6.1 6.6 32.2 6.4 6.5 32.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Gti1_Pac2 PF09729.9 CDI75603.1 - 6.4 6.8 27.5 7.1 6.7 27.5 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family DDRGK PF09756.9 CDI75603.1 - 6.8 6.2 42.2 7.6 6.1 42.2 1.0 1 0 0 1 1 1 0 DDRGK domain Connexin PF00029.19 CDI75603.1 - 9.2 5.9 24.3 11 5.7 24.3 1.1 1 0 0 1 1 1 0 Connexin RNA_pol_Rpc4 PF05132.14 CDI75603.1 - 9.8 6.6 26.0 11 6.5 26.0 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Pex14_N PF04695.13 CDI75604.1 - 0.00058 20.6 20.4 0.00067 20.4 20.4 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region RSB_motif PF16294.5 CDI75604.1 - 0.0016 18.7 12.4 0.0021 18.3 12.4 1.1 1 0 0 1 1 1 1 RNSP1-SAP18 binding (RSB) motif Pinin_SDK_memA PF04696.13 CDI75604.1 - 0.013 15.5 22.6 0.014 15.5 22.6 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region NARP1 PF12569.8 CDI75604.1 - 0.045 12.6 11.8 0.042 12.8 11.8 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 eIF3_subunit PF08597.10 CDI75604.1 - 0.048 13.6 12.2 0.048 13.6 12.2 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit RAB3GAP2_C PF14656.6 CDI75604.1 - 0.064 11.5 11.1 0.067 11.4 11.1 1.0 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus SpoIIP PF07454.11 CDI75604.1 - 0.075 12.5 16.4 0.07 12.6 16.4 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF5523 PF17661.1 CDI75604.1 - 0.084 12.5 14.6 0.087 12.5 14.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Eapp_C PF10238.9 CDI75604.1 - 0.092 12.8 12.6 0.094 12.8 12.6 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein Connexin PF00029.19 CDI75604.1 - 0.12 12.1 12.1 0.13 12.1 12.1 1.0 1 0 0 1 1 1 0 Connexin TFIIA PF03153.13 CDI75604.1 - 0.13 12.3 35.6 0.12 12.3 35.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FmiP_Thoc5 PF09766.9 CDI75604.1 - 0.13 11.5 19.4 0.14 11.4 19.4 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 DDHD PF02862.17 CDI75604.1 - 0.16 12.1 11.9 0.15 12.2 11.9 1.1 1 0 0 1 1 1 0 DDHD domain Dynactin_p62 PF05502.13 CDI75604.1 - 0.21 10.4 14.7 0.21 10.3 14.7 1.0 1 0 0 1 1 1 0 Dynactin p62 family EPL1 PF10513.9 CDI75604.1 - 0.23 11.9 15.6 0.27 11.6 15.6 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like FAM176 PF14851.6 CDI75604.1 - 0.24 11.1 9.2 0.24 11.0 9.2 1.1 1 0 0 1 1 1 0 FAM176 family CPSF100_C PF13299.6 CDI75604.1 - 0.26 11.5 12.2 0.26 11.5 12.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FancD2 PF14631.6 CDI75604.1 - 0.28 8.5 8.7 0.28 8.5 8.7 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Gti1_Pac2 PF09729.9 CDI75604.1 - 0.3 11.2 11.2 0.32 11.1 11.2 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family MecA PF05389.12 CDI75604.1 - 0.31 10.7 12.1 0.3 10.7 12.1 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Suf PF05843.14 CDI75604.1 - 0.34 10.9 17.5 0.46 10.4 17.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CCDC53 PF10152.9 CDI75604.1 - 0.35 11.3 15.1 0.39 11.1 15.1 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Tim54 PF11711.8 CDI75604.1 - 0.36 9.6 13.5 0.39 9.5 13.5 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 CDI75604.1 - 0.4 10.5 14.4 0.42 10.4 14.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4746 PF15928.5 CDI75604.1 - 0.42 10.0 11.4 0.44 9.9 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PIP5K PF01504.18 CDI75604.1 - 0.49 9.6 12.4 0.46 9.7 12.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF5308 PF17233.2 CDI75604.1 - 0.57 10.4 12.2 0.58 10.4 12.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Presenilin PF01080.17 CDI75604.1 - 0.6 8.8 19.1 0.67 8.7 19.1 1.0 1 0 0 1 1 1 0 Presenilin DNApol_Exo PF18136.1 CDI75604.1 - 0.62 9.2 12.2 0.66 9.1 12.2 1.0 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain EIIBC-GUT_N PF03612.14 CDI75604.1 - 0.63 9.8 13.5 0.71 9.6 13.5 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4770 PF15994.5 CDI75604.1 - 0.65 10.2 15.2 0.69 10.1 15.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) TERB2 PF15101.6 CDI75604.1 - 0.68 10.0 21.4 0.74 9.8 21.4 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Serinc PF03348.15 CDI75604.1 - 0.68 8.8 9.9 0.67 8.8 9.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) NPR3 PF03666.13 CDI75604.1 - 0.69 8.6 13.2 0.75 8.5 13.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF702 PF05142.12 CDI75604.1 - 0.73 10.3 12.2 0.86 10.1 12.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF702) RED_N PF07808.13 CDI75604.1 - 0.73 9.4 16.2 0.77 9.3 16.2 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region F-protein PF00469.20 CDI75604.1 - 0.75 9.3 11.4 0.73 9.4 11.4 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Peptidase_S64 PF08192.11 CDI75604.1 - 0.76 8.2 11.6 0.7 8.3 11.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 OATP PF03137.20 CDI75604.1 - 0.78 8.0 9.0 0.88 7.8 9.0 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family FAM60A PF15396.6 CDI75604.1 - 0.87 9.5 12.3 0.92 9.5 12.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF4638 PF15472.6 CDI75604.1 - 0.88 9.3 11.0 0.88 9.3 11.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF2126 PF09899.9 CDI75604.1 - 0.89 7.5 9.8 0.86 7.6 9.8 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CDC45 PF02724.14 CDI75604.1 - 0.91 7.7 11.9 0.91 7.7 11.9 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF2828 PF11443.8 CDI75604.1 - 0.93 7.5 13.9 0.9 7.6 13.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Ndc1_Nup PF09531.10 CDI75604.1 - 1 8.0 12.1 1.2 7.8 12.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SLC12 PF03522.15 CDI75604.1 - 1 8.3 15.0 0.96 8.4 15.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 ATAD4 PF15321.6 CDI75604.1 - 1 10.7 10.2 1.4 10.3 10.2 1.2 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 Pet20 PF08692.10 CDI75604.1 - 1 10.0 6.8 1.2 9.9 6.8 1.1 1 0 0 1 1 1 0 Mitochondrial protein Pet20 Sec62 PF03839.16 CDI75604.1 - 1.2 8.5 10.5 1.2 8.6 10.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 MMU163 PF17119.5 CDI75604.1 - 1.3 8.2 6.6 1.3 8.1 6.6 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis CLN3 PF02487.17 CDI75604.1 - 1.3 8.0 12.8 1.3 8.0 12.8 1.0 1 0 0 1 1 1 0 CLN3 protein RP-C_C PF11800.8 CDI75604.1 - 1.4 9.0 13.5 1.4 9.0 13.5 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region PAT1 PF09770.9 CDI75604.1 - 1.4 7.1 24.9 1.3 7.2 24.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Muted PF14942.6 CDI75604.1 - 1.5 9.2 21.6 1.6 9.0 21.6 1.1 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein CSG2 PF16965.5 CDI75604.1 - 1.5 7.7 9.0 1.4 7.8 9.0 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator ALMT PF11744.8 CDI75604.1 - 1.5 7.6 12.1 1.4 7.6 12.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM91_C PF14648.6 CDI75604.1 - 1.6 7.5 9.1 1.5 7.6 9.1 1.1 1 0 0 1 1 1 0 FAM91 C-terminus MDM10 PF12519.8 CDI75604.1 - 1.7 7.4 13.5 1.6 7.5 13.5 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Neur_chan_memb PF02932.16 CDI75604.1 - 1.8 8.6 11.2 1.7 8.6 11.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PepSY_TM PF03929.16 CDI75604.1 - 2 8.0 8.2 2 8.0 8.2 1.1 1 0 0 1 1 1 0 PepSY-associated TM region DUF853 PF05872.12 CDI75604.1 - 2.1 6.8 10.1 2 6.9 10.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) GOLD_2 PF13897.6 CDI75604.1 - 2.2 8.8 6.2 2.7 8.5 6.2 1.1 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF913 PF06025.12 CDI75604.1 - 2.2 7.1 10.9 2.4 7.0 10.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF1764 PF08576.10 CDI75604.1 - 2.2 9.2 14.0 2.7 8.9 14.0 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Kei1 PF08552.11 CDI75604.1 - 2.3 8.0 9.5 2.4 8.0 9.5 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF2347 PF09804.9 CDI75604.1 - 2.4 7.7 9.1 2.5 7.6 9.1 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Folate_carrier PF01770.18 CDI75604.1 - 2.5 6.7 8.5 2.4 6.8 8.5 1.1 1 0 0 1 1 1 0 Reduced folate carrier REC114-like PF15165.6 CDI75604.1 - 2.6 7.8 18.7 2.6 7.8 18.7 1.0 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like Rxt3 PF08642.10 CDI75604.1 - 2.6 8.8 9.3 3.4 8.4 9.3 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Ureide_permease PF07168.11 CDI75604.1 - 2.9 6.5 10.0 3.2 6.4 10.0 1.0 1 0 0 1 1 1 0 Ureide permease FAM150 PF15129.6 CDI75604.1 - 3 8.0 13.8 3.5 7.8 13.8 1.2 1 0 0 1 1 1 0 FAM150 family ABC2_membrane_2 PF12679.7 CDI75604.1 - 3 7.0 7.3 3.7 6.8 7.3 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DDRGK PF09756.9 CDI75604.1 - 3.2 7.3 22.6 3.6 7.1 22.6 1.0 1 0 0 1 1 1 0 DDRGK domain Hid1 PF12722.7 CDI75604.1 - 3.4 5.7 14.8 3.4 5.7 14.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MRP-S26 PF14943.6 CDI75604.1 - 3.6 7.5 18.8 4.3 7.2 18.8 1.1 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 DUF1800 PF08811.11 CDI75604.1 - 3.7 6.5 16.6 3.8 6.4 16.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) DUF3371 PF11851.8 CDI75604.1 - 4.4 8.4 17.8 5.2 8.2 17.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) DUF3292 PF11696.8 CDI75604.1 - 4.5 5.5 10.5 4.5 5.5 10.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Ctr PF04145.15 CDI75604.1 - 4.8 7.8 8.9 5.2 7.7 8.9 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Band_3_cyto PF07565.13 CDI75604.1 - 4.9 6.9 16.6 5.1 6.8 16.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SID-1_RNA_chan PF13965.6 CDI75604.1 - 5.2 5.3 9.9 4.9 5.4 9.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Membralin PF09746.9 CDI75604.1 - 5.3 6.0 11.3 5.2 6.0 11.3 1.0 1 0 0 1 1 1 0 Tumour-associated protein MDM31_MDM32 PF08118.11 CDI75604.1 - 5.4 5.6 12.2 5.4 5.6 12.2 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Otopetrin PF03189.13 CDI75604.1 - 5.6 5.7 9.7 5.4 5.7 9.7 1.0 1 0 0 1 1 1 0 Otopetrin CobT PF06213.12 CDI75604.1 - 5.7 6.3 26.3 6.1 6.2 26.3 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT YABBY PF04690.13 CDI75604.1 - 5.9 7.4 12.9 6 7.4 12.9 1.1 1 0 0 1 1 1 0 YABBY protein Folliculin PF11704.8 CDI75604.1 - 6.2 6.7 12.8 6.9 6.5 12.8 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF4175 PF13779.6 CDI75604.1 - 6.4 4.6 36.7 6.2 4.6 36.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Peptidase_U57 PF05582.12 CDI75604.1 - 6.5 5.9 11.5 6.8 5.9 11.5 1.1 1 0 0 1 1 1 0 YabG peptidase U57 ATP-synt_E PF05680.12 CDI75604.1 - 6.6 7.2 14.6 7.4 7.0 14.6 1.1 1 0 0 1 1 1 0 ATP synthase E chain DUF4820 PF16091.5 CDI75604.1 - 6.6 6.0 15.0 8.8 5.6 15.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF3464 PF11947.8 CDI75604.1 - 6.7 6.4 19.6 8.4 6.1 19.6 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 HCO3_cotransp PF00955.21 CDI75604.1 - 6.8 5.4 6.9 6.1 5.5 6.9 1.0 1 0 0 1 1 1 0 HCO3- transporter family Peptidase_S49_N PF08496.10 CDI75604.1 - 6.9 6.7 13.7 8.6 6.4 13.7 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MMR1 PF08505.10 CDI75604.1 - 7.1 6.8 19.7 7.1 6.8 19.7 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Pannexin_like PF12534.8 CDI75604.1 - 7.1 5.6 12.4 7.9 5.5 12.4 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Baculo_PP31 PF05311.11 CDI75604.1 - 7.6 5.9 17.3 8.6 5.7 17.3 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) FHIPEP PF00771.20 CDI75604.1 - 7.8 4.8 10.4 8 4.8 10.4 1.1 1 0 0 1 1 1 0 FHIPEP family PPL5 PF18168.1 CDI75604.1 - 9.6 5.4 13.3 10 5.3 13.3 1.0 1 0 0 1 1 1 0 Prim-pol family 5 TAF4 PF05236.14 CDI75605.1 - 8e-05 22.5 14.1 8e-05 22.5 14.1 5.6 3 2 0 4 4 4 2 Transcription initiation factor TFIID component TAF4 family SUIM_assoc PF16619.5 CDI75606.1 - 0.031 14.3 0.6 0.031 14.3 0.6 10.1 4 3 3 7 7 7 0 Unstructured region C-term to UIM in Ataxin3 CLN3 PF02487.17 CDI75607.1 - 0.00098 18.3 6.2 0.00098 18.3 6.2 3.5 2 1 1 3 3 2 1 CLN3 protein PAT1 PF09770.9 CDI75607.1 - 0.0014 17.0 32.4 0.0014 17.0 32.4 2.6 3 0 0 3 3 3 1 Topoisomerase II-associated protein PAT1 Plasmodium_Vir PF05795.11 CDI75607.1 - 0.0031 17.0 13.0 0.22 10.9 5.3 2.2 2 0 0 2 2 2 2 Plasmodium vivax Vir protein DUF2722 PF10846.8 CDI75607.1 - 0.0041 16.1 16.9 0.0041 16.1 16.9 4.5 2 1 2 4 4 1 1 Protein of unknown function (DUF2722) Tim54 PF11711.8 CDI75607.1 - 0.0083 14.9 1.2 0.0083 14.9 1.2 3.4 3 0 0 3 3 3 1 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 CDI75607.1 - 0.072 12.9 38.9 0.91 9.3 10.6 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 MRP-S31 PF15433.6 CDI75607.1 - 1.6 8.3 40.3 1 8.9 22.7 2.2 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 DUF4471 PF14740.6 CDI75607.1 - 3.1 7.0 26.5 0.72 9.0 2.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) CDC45 PF02724.14 CDI75607.1 - 3.4 5.9 30.4 2.6 6.3 13.5 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF4746 PF15928.5 CDI75607.1 - 6.1 6.2 30.5 0.57 9.6 5.3 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4746) LAP1C PF05609.12 CDI75607.1 - 6.6 5.7 43.7 1.3 8.0 7.6 2.3 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) FAM60A PF15396.6 CDI75607.1 - 9.3 6.2 34.8 0.46 10.5 7.0 2.3 2 0 0 2 2 2 0 Protein Family FAM60A TMEM100 PF16311.5 CDI75608.1 - 0.013 15.0 0.4 0.013 15.0 0.4 1.8 2 0 0 2 2 2 0 Transmembrane protein 100 PRP38_assoc PF12871.7 CDI75608.1 - 0.034 14.8 26.7 0.034 14.8 26.7 2.7 3 0 0 3 3 3 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term TFIIA PF03153.13 CDI75608.1 - 0.068 13.2 55.8 0.048 13.6 5.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Jas PF16135.5 CDI75608.1 - 0.081 13.1 0.9 0.23 11.6 0.9 1.8 1 0 0 1 1 1 0 TPL-binding domain in jasmonate signalling OATP PF03137.20 CDI75608.1 - 0.13 10.5 0.0 0.13 10.5 0.0 2.4 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Afi1 PF07792.12 CDI75608.1 - 0.23 12.0 26.4 0.83 10.1 2.7 3.1 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4834 PF16118.5 CDI75608.1 - 0.64 11.0 30.7 22 6.1 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) LptF_LptG PF03739.14 CDI75608.1 - 0.91 8.3 4.0 1.3 7.8 4.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Folate_carrier PF01770.18 CDI75608.1 - 1.9 7.1 14.0 0.18 10.5 6.8 2.2 2 1 0 2 2 2 0 Reduced folate carrier G0-G1_switch_2 PF15103.6 CDI75608.1 - 2.1 8.8 20.6 13 6.3 10.3 3.3 3 0 0 3 3 3 0 G0/G1 switch protein 2 DUF4175 PF13779.6 CDI75608.1 - 4 5.2 50.4 0.026 12.4 38.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) RPA43_OB PF17875.1 CDI75608.1 - 4.1 8.0 24.1 0.087 13.5 9.3 3.0 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I XRN_M PF17846.1 CDI75608.1 - 6.9 5.5 15.6 1.3 7.9 8.3 2.1 2 0 0 2 2 2 0 Xrn1 helical domain SpoIIIAH PF12685.7 CDI75609.1 - 3.3 7.5 11.7 3.6 7.4 11.7 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein FRG2 PF15315.6 CDI75609.1 - 4.1 7.6 10.7 4.8 7.3 10.7 1.1 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 Tim54 PF11711.8 CDI75609.1 - 4.8 5.9 12.5 4.9 5.8 12.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF789 PF05623.12 CDI75609.1 - 5.1 6.7 8.5 5.4 6.6 8.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF789) RR_TM4-6 PF06459.12 CDI75609.1 - 8.2 6.2 17.9 8.9 6.0 17.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 IMPDH PF00478.25 CDI75611.1 - 1.6e-132 441.7 0.1 2.7e-80 270.0 8.2 2.1 1 1 1 2 2 2 2 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 CDI75611.1 - 9e-12 45.0 2.6 1.6e-07 31.0 2.4 3.1 3 0 0 3 3 3 2 Nitronate monooxygenase CBS PF00571.28 CDI75611.1 - 3.5e-11 43.4 0.1 0.0004 20.8 0.0 3.0 3 0 0 3 3 2 2 CBS domain FMN_dh PF01070.18 CDI75611.1 - 6.6e-10 38.5 3.4 6.6e-10 38.5 1.7 1.8 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 CDI75611.1 - 2.2e-06 27.3 3.7 0.00023 20.7 3.7 3.3 1 1 0 1 1 1 1 Histidine biosynthesis protein NanE PF04131.14 CDI75611.1 - 0.00042 19.5 1.2 0.42 9.8 0.1 3.2 2 1 0 3 3 3 2 Putative N-acetylmannosamine-6-phosphate epimerase ThiG PF05690.14 CDI75611.1 - 0.00072 18.9 1.1 0.0015 17.9 1.1 1.5 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 CDI75611.1 - 0.032 13.7 0.5 0.59 9.5 0.1 2.5 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator Glu_synthase PF01645.17 CDI75611.1 - 0.037 13.2 2.0 0.085 12.0 2.0 1.6 1 0 0 1 1 1 0 Conserved region in glutamate synthase DHO_dh PF01180.21 CDI75611.1 - 0.06 12.5 1.1 0.16 11.2 1.3 1.6 1 1 1 2 2 2 0 Dihydroorotate dehydrogenase TMP-TENI PF02581.17 CDI75611.1 - 0.11 11.8 2.8 0.36 10.1 2.3 2.2 2 1 0 2 2 2 0 Thiamine monophosphate synthase Stork_head PF10264.9 CDI75611.1 - 0.11 12.6 0.0 15 5.8 0.0 2.8 2 1 1 3 3 3 0 Winged helix Storkhead-box1 domain NAD_binding_7 PF13241.6 CDI75611.1 - 0.13 12.7 0.2 20 5.7 0.1 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding Pkinase PF00069.25 CDI75613.1 - 2.6e-35 122.1 0.0 5.9e-35 120.9 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI75613.1 - 3.5e-23 82.2 0.0 5.8e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDI75613.1 - 0.053 13.4 0.3 0.11 12.5 0.1 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family PUA_3 PF17785.1 CDI75614.1 - 4.5e-06 26.4 0.0 1.2e-05 25.0 0.0 1.7 1 1 0 1 1 1 1 PUA-like domain LRV PF01816.17 CDI75614.1 - 0.095 13.1 3.4 0.41 11.1 3.4 2.3 1 0 0 1 1 1 0 Leucine rich repeat variant PAM2 PF07145.15 CDI75615.1 - 4.7e-05 22.8 1.5 0.00011 21.6 1.5 1.6 1 0 0 1 1 1 1 Ataxin-2 C-terminal region RskA PF10099.9 CDI75616.1 - 2.8e-05 24.5 15.7 2.8e-05 24.5 15.7 5.8 1 1 3 4 4 4 1 Anti-sigma-K factor rskA Mucin PF01456.17 CDI75616.1 - 0.0068 16.4 16.2 0.0068 16.4 16.2 5.0 1 1 3 4 4 4 1 Mucin-like glycoprotein Spt20 PF12090.8 CDI75616.1 - 0.67 9.5 27.9 0.021 14.4 19.4 2.1 2 0 0 2 2 2 0 Spt20 family Bud13 PF09736.9 CDI75616.1 - 6.2 7.2 11.6 2.1 8.7 6.4 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex RskA PF10099.9 CDI75618.1 - 0.33 11.2 0.0 0.33 11.2 0.0 5.2 1 1 2 3 3 3 0 Anti-sigma-K factor rskA SID-1_RNA_chan PF13965.6 CDI75618.1 - 7.3 4.9 6.1 14 3.9 1.4 2.4 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 GrpE PF01025.19 CDI75619.1 - 1.6e-30 106.0 12.6 1.9e-29 102.5 12.6 2.6 1 1 0 1 1 1 1 GrpE DUF4168 PF13767.6 CDI75619.1 - 0.0034 18.5 12.6 0.0034 18.5 12.6 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4168) Tir_receptor_N PF07490.11 CDI75619.1 - 0.0057 16.5 6.3 0.0077 16.1 6.3 1.1 1 0 0 1 1 1 1 Translocated intimin receptor (Tir) N-terminus SurA_N_2 PF13623.6 CDI75619.1 - 0.045 13.6 13.3 0.12 12.3 13.3 1.7 1 0 0 1 1 1 0 SurA N-terminal domain FH2 PF02181.23 CDI75619.1 - 0.074 12.2 7.6 0.089 11.9 7.6 1.1 1 0 0 1 1 1 0 Formin Homology 2 Domain GET2 PF08690.10 CDI75619.1 - 0.34 10.5 13.4 0.36 10.5 13.4 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 BROMI PF14961.6 CDI75619.1 - 0.36 8.2 5.8 0.43 7.9 5.8 1.0 1 0 0 1 1 1 0 Broad-minded protein Cwf_Cwc_15 PF04889.12 CDI75619.1 - 0.41 10.3 14.9 0.57 9.9 14.9 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SprA-related PF12118.8 CDI75619.1 - 0.51 9.4 25.1 0.63 9.1 25.1 1.1 1 0 0 1 1 1 0 SprA-related family DUF1664 PF07889.12 CDI75619.1 - 0.55 10.3 10.6 0.73 9.9 9.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) USP8_interact PF08941.10 CDI75619.1 - 0.69 9.7 7.8 1.1 9.0 7.8 1.3 1 0 0 1 1 1 0 USP8 interacting Het-C PF07217.11 CDI75619.1 - 0.71 8.3 7.1 0.89 8.0 7.1 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Suf PF05843.14 CDI75619.1 - 0.73 9.8 10.4 0.88 9.5 10.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Prominin PF05478.11 CDI75619.1 - 0.91 7.4 8.8 1.2 7.1 8.8 1.1 1 0 0 1 1 1 0 Prominin DUF4559 PF15112.6 CDI75619.1 - 0.93 9.1 10.4 1.2 8.7 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) EMC3_TMCO1 PF01956.16 CDI75619.1 - 1 9.1 4.2 1.3 8.7 4.2 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like MTP18 PF10558.9 CDI75619.1 - 1.3 9.0 3.4 2 8.3 2.7 1.7 1 1 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) Presenilin PF01080.17 CDI75619.1 - 1.4 7.6 13.1 1.7 7.3 13.1 1.2 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 CDI75619.1 - 1.9 7.1 11.6 2.4 6.7 11.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PRP1_N PF06424.12 CDI75619.1 - 2 8.8 13.5 2.9 8.3 13.5 1.3 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal NRN1 PF15056.6 CDI75619.1 - 2.2 8.4 6.6 4.9 7.3 5.0 2.3 1 1 1 2 2 2 0 Neuritin protein family SpoIIIAH PF12685.7 CDI75619.1 - 2.2 8.1 25.3 2.9 7.7 25.3 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Macoilin PF09726.9 CDI75619.1 - 2.4 6.6 12.1 3.4 6.1 12.1 1.2 1 0 0 1 1 1 0 Macoilin family eIF-3_zeta PF05091.12 CDI75619.1 - 2.9 6.8 13.3 3.6 6.5 13.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ZYG-11_interact PF05884.12 CDI75619.1 - 3 7.2 11.7 4.3 6.7 11.7 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 V_ATPase_I PF01496.19 CDI75619.1 - 3.5 5.4 8.8 4.5 5.1 8.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FlaG PF03646.15 CDI75619.1 - 4.1 7.6 22.9 0.35 11.1 14.1 2.4 2 1 0 2 2 2 0 FlaG protein DUF4914 PF16260.5 CDI75619.1 - 4.5 5.2 7.3 4.4 5.3 5.8 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4914) DUF4407 PF14362.6 CDI75619.1 - 5.8 6.2 12.2 7.9 5.7 12.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1525 PF07511.11 CDI75619.1 - 6.8 6.9 15.1 9.1 6.5 14.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1525) Sox_N PF12444.8 CDI75619.1 - 7.4 7.8 15.0 2.2 9.4 2.1 2.4 2 0 0 2 2 2 0 Sox developmental protein N terminal DUF4834 PF16118.5 CDI75619.1 - 7.5 7.6 15.9 0.29 12.1 5.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Inj_translocase PF16928.5 CDI75620.1 - 0.43 10.0 8.6 0.86 9.0 8.6 1.4 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome RskA PF10099.9 CDI75620.1 - 5.6 7.2 14.6 1.4 9.2 5.8 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA FHIPEP PF00771.20 CDI75621.1 - 4.3 5.7 12.1 4.8 5.5 12.1 1.0 1 0 0 1 1 1 0 FHIPEP family Macoilin PF09726.9 CDI75621.1 - 4.4 5.7 12.5 4.9 5.6 12.5 1.0 1 0 0 1 1 1 0 Macoilin family NUDE_C PF04880.13 CDI75621.1 - 4.4 7.7 13.4 4.8 7.6 13.4 1.0 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region TFIIA PF03153.13 CDI75621.1 - 6.3 6.7 33.6 6.9 6.6 33.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM199X PF15814.5 CDI75621.1 - 6.9 5.6 19.4 8.1 5.4 19.4 1.0 1 0 0 1 1 1 0 Protein family FAM199X SLC12 PF03522.15 CDI75622.1 - 0.11 11.5 52.4 0.14 11.1 52.4 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Asp-B-Hydro_N PF05279.11 CDI75622.1 - 1.9 8.5 39.3 2.2 8.3 39.3 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Vac7 PF12751.7 CDI75622.1 - 9.4 5.5 37.1 11 5.4 37.1 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 DUF2722 PF10846.8 CDI75623.1 - 0.0038 16.2 5.9 0.0038 16.2 5.9 9.2 8 2 0 8 8 8 3 Protein of unknown function (DUF2722) Spore_YhcN_YlaJ PF09580.10 CDI75623.1 - 0.14 12.2 0.1 0.14 12.2 0.1 5.1 3 2 1 4 4 4 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) PIEZO PF15917.5 CDI75624.1 - 0.022 14.3 29.4 0.028 13.9 29.4 1.3 1 0 0 1 1 1 0 Piezo DDRGK PF09756.9 CDI75624.1 - 0.084 12.5 33.9 0.12 12.0 33.9 1.3 1 0 0 1 1 1 0 DDRGK domain Miga PF10265.9 CDI75624.1 - 0.09 11.7 25.1 0.12 11.3 25.1 1.2 1 0 0 1 1 1 0 Mitoguardin DUF4647 PF15504.6 CDI75624.1 - 0.46 9.5 29.8 0.59 9.2 29.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Membralin PF09746.9 CDI75624.1 - 2.1 7.3 16.3 2.5 7.0 16.3 1.3 1 0 0 1 1 1 0 Tumour-associated protein VIR_N PF15912.5 CDI75624.1 - 2.3 7.8 13.2 3.1 7.3 13.2 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Lin-8 PF03353.15 CDI75624.1 - 2.5 7.6 35.5 3.1 7.3 35.5 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist LptF_LptG PF03739.14 CDI75624.1 - 3.3 6.5 8.1 4 6.2 8.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG WDCP PF15390.6 CDI75624.1 - 3.7 5.8 20.9 4.3 5.6 20.9 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family CRT10 PF08728.10 CDI75624.1 - 4.5 5.3 13.0 5 5.2 13.0 1.0 1 0 0 1 1 1 0 CRT10 Apt1 PF10351.9 CDI75624.1 - 4.7 6.0 19.3 5.4 5.8 19.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4638 PF15472.6 CDI75624.1 - 5 6.8 23.5 6.6 6.4 23.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) SOBP PF15279.6 CDI75624.1 - 8.1 7.0 27.7 10 6.6 27.7 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein RAP1 PF07218.11 CDI75625.1 - 0.58 8.4 12.1 1 7.5 12.1 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) TMEM51 PF15345.6 CDI75626.1 - 0.044 13.6 34.4 0.23 11.3 10.2 2.0 1 1 1 2 2 2 0 Transmembrane protein 51 Baculo_E56 PF04639.12 CDI75626.1 - 0.075 12.3 0.3 0.11 11.8 0.3 1.2 1 0 0 1 1 1 0 Baculoviral E56 protein, specific to ODV envelope Conotoxin PF02950.17 CDI75626.1 - 0.15 13.1 0.8 0.15 13.1 0.8 3.1 3 1 0 3 3 3 0 Conotoxin FAM176 PF14851.6 CDI75626.1 - 0.35 10.5 15.5 0.64 9.7 0.2 2.3 2 1 0 2 2 2 0 FAM176 family eIF3_p135 PF12807.7 CDI75626.1 - 0.53 10.3 20.5 0.13 12.3 4.1 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 Paf1 PF03985.13 CDI75626.1 - 0.81 8.6 20.8 0.3 10.0 2.4 2.1 2 0 0 2 2 2 0 Paf1 Pinin_SDK_memA PF04696.13 CDI75626.1 - 0.98 9.5 40.1 1 9.4 16.0 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region RNA_replicase_B PF03431.13 CDI75626.1 - 1.1 7.7 8.6 1.4 7.2 8.6 1.3 1 0 0 1 1 1 0 RNA replicase, beta-chain PE_PPE_C PF12484.8 CDI75626.1 - 1.1 10.2 30.5 0.23 12.4 9.8 2.3 2 0 0 2 2 2 0 Polymorphic PE/PPE proteins C terminal DUF5523 PF17661.1 CDI75626.1 - 1.3 8.6 19.8 1 9.0 2.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5523) TRM13 PF05206.14 CDI75626.1 - 1.5 8.3 18.0 0.98 8.9 2.8 2.2 2 0 0 2 2 2 0 Methyltransferase TRM13 Spem1 PF15670.5 CDI75626.1 - 1.7 8.2 19.7 2.3 7.7 10.0 2.1 2 0 0 2 2 2 0 Spermatid maturation protein 1 EOS1 PF12326.8 CDI75626.1 - 3 7.7 15.9 1.4 8.9 2.4 2.2 2 0 0 2 2 2 0 N-glycosylation protein CD20 PF04103.15 CDI75626.1 - 3.2 7.8 12.1 2.3 8.3 0.1 2.5 3 0 0 3 3 3 0 CD20-like family Pertussis_S1 PF02917.14 CDI75626.1 - 3.9 7.2 17.1 0.83 9.4 12.7 1.9 1 1 1 2 2 2 0 Pertussis toxin, subunit 1 Dpy19 PF10034.9 CDI75626.1 - 5.3 5.1 9.4 3.8 5.6 1.2 2.1 2 0 0 2 2 2 0 Q-cell neuroblast polarisation SID-1_RNA_chan PF13965.6 CDI75626.1 - 5.5 5.3 14.5 1.6 7.0 1.5 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 VIT1 PF01988.19 CDI75626.1 - 5.8 6.7 24.1 1.3 8.8 7.2 2.2 2 0 0 2 2 2 0 VIT family AAA_23 PF13476.6 CDI75626.1 - 9 6.7 25.2 0.33 11.4 2.8 2.1 2 0 0 2 2 2 0 AAA domain Peptidase_U57 PF05582.12 CDI75626.1 - 9.4 5.4 18.0 7.5 5.7 1.4 2.2 2 0 0 2 2 2 0 YabG peptidase U57 CobT PF06213.12 CDI75627.1 - 2.8 7.3 48.9 0.52 9.7 29.8 2.0 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT RXT2_N PF08595.11 CDI75627.1 - 5.8 6.9 27.2 5.8 6.9 14.6 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal SAPS PF04499.15 CDI75627.1 - 7.1 5.3 27.0 8.8 5.0 27.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SpoIIIAH PF12685.7 CDI75627.1 - 8.6 6.1 36.4 10 5.9 36.4 1.0 1 0 0 1 1 1 0 SpoIIIAH-like protein SOBP PF15279.6 CDI75628.1 - 0.04 14.5 19.1 0.048 14.3 19.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein ICA69 PF04629.14 CDI75628.1 - 0.11 12.8 26.2 0.13 12.5 26.2 1.1 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain PA26 PF04636.13 CDI75628.1 - 0.21 10.5 19.3 0.26 10.2 19.3 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PAT1 PF09770.9 CDI75628.1 - 0.3 9.3 45.3 0.37 9.0 45.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Draxin PF15550.6 CDI75628.1 - 0.3 10.9 23.3 0.44 10.4 23.3 1.3 1 0 0 1 1 1 0 Draxin Lin-8 PF03353.15 CDI75628.1 - 2.7 7.5 33.4 3.8 7.0 33.4 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist GREB1 PF15782.5 CDI75628.1 - 6.3 3.8 28.9 7.4 3.5 28.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MDM10 PF12519.8 CDI75628.1 - 7.1 5.4 24.3 12 4.7 24.3 1.4 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SLC12 PF03522.15 CDI75628.1 - 9.8 5.1 34.3 14 4.5 34.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Exonuc_VII_L PF02601.15 CDI75629.1 - 0.021 14.4 12.5 0.025 14.2 12.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit EPV_E5 PF08135.11 CDI75629.1 - 0.1 13.0 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 Major transforming protein E5 family MID_MedPIWI PF18296.1 CDI75629.1 - 0.66 9.7 14.4 0.21 11.3 11.8 1.5 2 0 0 2 2 2 0 MID domain of medPIWI FAM60A PF15396.6 CDI75629.1 - 0.74 9.8 10.0 1.3 9.0 10.0 1.5 1 0 0 1 1 1 0 Protein Family FAM60A Macoilin PF09726.9 CDI75629.1 - 0.93 8.0 12.9 1.2 7.7 12.9 1.1 1 0 0 1 1 1 0 Macoilin family GET2 PF08690.10 CDI75629.1 - 0.97 9.0 20.9 4.5 6.8 19.2 2.1 2 0 0 2 2 2 0 GET complex subunit GET2 Band_3_cyto PF07565.13 CDI75629.1 - 1.5 8.6 13.9 2.3 7.9 13.9 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain VIR_N PF15912.5 CDI75629.1 - 1.7 8.2 13.0 2.4 7.7 13.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal PAT1 PF09770.9 CDI75629.1 - 1.7 6.8 28.0 2.1 6.5 28.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Paf1 PF03985.13 CDI75629.1 - 2.1 7.3 19.7 3.2 6.6 19.7 1.3 1 0 0 1 1 1 0 Paf1 Suf PF05843.14 CDI75629.1 - 2.2 8.2 18.9 3.4 7.6 18.9 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3552 PF12072.8 CDI75629.1 - 2.2 7.6 21.1 5 6.5 21.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) SLC12 PF03522.15 CDI75629.1 - 3.2 6.7 13.5 4.2 6.3 13.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 CobT PF06213.12 CDI75629.1 - 3.4 7.0 28.7 0.038 13.4 20.7 1.8 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 CDI75629.1 - 3.7 6.2 21.0 15 4.2 20.2 2.0 2 0 0 2 2 2 0 Presenilin Myc_N PF01056.18 CDI75629.1 - 4.4 7.1 15.2 0.17 11.7 8.0 1.9 2 0 0 2 2 2 0 Myc amino-terminal region ALMT PF11744.8 CDI75629.1 - 5.5 5.7 9.5 8 5.2 9.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3408 PF11888.8 CDI75629.1 - 6.1 7.0 16.8 14 5.8 16.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) TFB6 PF17110.5 CDI75629.1 - 7.1 6.3 8.1 11 5.8 8.1 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH GREB1 PF15782.5 CDI75629.1 - 7.1 3.6 14.6 8.4 3.4 14.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer eIF-3_zeta PF05091.12 CDI75629.1 - 7.2 5.5 19.2 9.1 5.1 19.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SMN PF06003.12 CDI75631.1 - 0.032 13.5 7.7 0.036 13.3 7.7 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Mersacidin PF16934.5 CDI75631.1 - 0.084 12.7 2.5 0.12 12.2 2.5 1.1 1 0 0 1 1 1 0 Two-component Enterococcus faecalis cytolysin (EFC) SID-1_RNA_chan PF13965.6 CDI75631.1 - 0.14 10.5 11.9 0.17 10.3 11.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI75631.1 - 0.17 10.8 16.9 0.19 10.6 16.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Peptidase_S49_N PF08496.10 CDI75631.1 - 0.5 10.4 23.5 0.69 10.0 23.5 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FAM60A PF15396.6 CDI75631.1 - 0.52 10.3 20.8 0.58 10.1 20.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A CDC45 PF02724.14 CDI75631.1 - 0.85 7.8 23.2 0.79 7.9 23.2 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 CDI75631.1 - 0.85 8.3 26.0 0.83 8.4 26.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CSG2 PF16965.5 CDI75631.1 - 1.2 8.1 13.6 1.1 8.1 13.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 CDI75631.1 - 1.3 8.0 20.9 1.4 7.8 20.9 1.2 1 0 0 1 1 1 0 CLN3 protein DUF2828 PF11443.8 CDI75631.1 - 1.6 6.7 25.1 1.5 6.8 25.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Paf1 PF03985.13 CDI75631.1 - 2.3 7.1 31.1 2.7 6.9 31.1 1.2 1 0 0 1 1 1 0 Paf1 DUF913 PF06025.12 CDI75631.1 - 2.8 6.8 19.8 3.1 6.7 19.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PPP4R2 PF09184.11 CDI75631.1 - 3 7.3 18.8 3.1 7.3 18.8 1.1 1 0 0 1 1 1 0 PPP4R2 SLC12 PF03522.15 CDI75631.1 - 3.1 6.7 30.1 3.3 6.6 30.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Miga PF10265.9 CDI75631.1 - 3.8 6.4 18.5 4.4 6.2 18.5 1.0 1 0 0 1 1 1 0 Mitoguardin Presenilin PF01080.17 CDI75631.1 - 4.5 5.9 39.0 5.4 5.7 39.0 1.2 1 0 0 1 1 1 0 Presenilin SART-1 PF03343.13 CDI75631.1 - 5.7 5.4 33.1 6.2 5.2 33.1 1.1 1 0 0 1 1 1 0 SART-1 family CD20 PF04103.15 CDI75631.1 - 5.9 7.0 10.8 32 4.6 10.8 1.9 1 1 0 1 1 1 0 CD20-like family O-antigen_lig PF13425.6 CDI75631.1 - 7.3 5.3 15.1 8.1 5.1 15.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF2126 PF09899.9 CDI75631.1 - 8.5 4.3 21.6 9.4 4.2 21.6 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Red1 PF07964.11 CDI75632.1 - 1.5 7.0 40.1 2.3 6.4 40.1 1.1 1 0 0 1 1 1 0 Rec10 / Red1 BAF1_ABF1 PF04684.13 CDI75634.1 - 0.0002 20.6 13.9 0.00022 20.4 13.9 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor TFIIA PF03153.13 CDI75634.1 - 0.00041 20.5 34.4 0.00042 20.4 34.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SprA-related PF12118.8 CDI75634.1 - 0.001 18.3 33.5 0.0013 17.9 33.5 1.1 1 0 0 1 1 1 1 SprA-related family RPOL_N PF14700.6 CDI75634.1 - 0.0012 18.3 11.0 0.0012 18.3 11.0 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal eIF-3_zeta PF05091.12 CDI75634.1 - 0.0065 15.5 15.5 0.0069 15.4 15.5 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Baculo_PP31 PF05311.11 CDI75634.1 - 0.0076 15.8 8.0 0.011 15.2 8.0 1.3 1 0 0 1 1 1 1 Baculovirus 33KDa late protein (PP31) SID-1_RNA_chan PF13965.6 CDI75634.1 - 0.011 14.2 3.9 0.012 14.1 3.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Activator_LAG-3 PF11498.8 CDI75634.1 - 0.016 14.2 37.0 0.019 14.0 37.0 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SLC12 PF03522.15 CDI75634.1 - 0.041 12.9 9.9 0.038 13.0 9.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Band_3_cyto PF07565.13 CDI75634.1 - 0.051 13.4 9.4 0.068 13.0 9.4 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain UCR_TM PF02921.14 CDI75634.1 - 0.053 14.0 2.6 0.061 13.8 0.1 2.2 2 0 0 2 2 1 0 Ubiquinol cytochrome reductase transmembrane region CobT PF06213.12 CDI75634.1 - 0.063 12.7 21.4 0.1 11.9 21.4 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT ArsP_2 PF11449.8 CDI75634.1 - 0.065 12.4 3.0 0.084 12.1 3.0 1.1 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter SpoIIP PF07454.11 CDI75634.1 - 0.067 12.6 14.7 0.092 12.2 14.7 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Neur_chan_memb PF02932.16 CDI75634.1 - 0.075 13.1 8.1 0.083 12.9 8.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM91_C PF14648.6 CDI75634.1 - 0.12 11.2 6.9 0.15 10.9 6.9 1.2 1 0 0 1 1 1 0 FAM91 C-terminus MAJIN PF15077.6 CDI75634.1 - 0.12 12.2 5.0 0.13 12.0 5.0 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Serinc PF03348.15 CDI75634.1 - 0.14 11.1 8.9 0.17 10.8 8.9 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) PAT1 PF09770.9 CDI75634.1 - 0.19 10.0 24.0 0.22 9.7 24.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PA26 PF04636.13 CDI75634.1 - 0.2 10.5 8.2 0.25 10.2 8.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Chorismate_synt PF01264.21 CDI75634.1 - 0.25 10.0 7.0 0.31 9.7 7.0 1.1 1 0 0 1 1 1 0 Chorismate synthase DUF572 PF04502.13 CDI75634.1 - 0.26 10.9 14.0 0.33 10.5 14.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Paf1 PF03985.13 CDI75634.1 - 0.26 10.2 15.2 0.37 9.8 15.2 1.3 1 0 0 1 1 1 0 Paf1 Peptidase_S49_N PF08496.10 CDI75634.1 - 0.29 11.2 10.5 0.4 10.7 10.5 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Borrelia_P83 PF05262.11 CDI75634.1 - 0.3 9.5 15.4 0.31 9.5 15.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein RR_TM4-6 PF06459.12 CDI75634.1 - 0.31 10.8 15.6 0.4 10.5 15.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 V_ATPase_I PF01496.19 CDI75634.1 - 0.39 8.6 12.8 0.43 8.4 12.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TFB6 PF17110.5 CDI75634.1 - 0.49 10.1 8.3 0.71 9.6 8.3 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH NEMP PF10225.9 CDI75634.1 - 0.5 10.0 3.3 0.8 9.3 3.3 1.4 1 0 0 1 1 1 0 NEMP family Het-C PF07217.11 CDI75634.1 - 0.6 8.6 7.8 0.64 8.5 7.8 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Ureide_permease PF07168.11 CDI75634.1 - 0.67 8.7 6.4 0.94 8.2 6.4 1.3 1 0 0 1 1 1 0 Ureide permease AMP-binding PF00501.28 CDI75634.1 - 0.69 8.4 4.8 0.78 8.3 4.8 1.1 1 0 0 1 1 1 0 AMP-binding enzyme CPSF100_C PF13299.6 CDI75634.1 - 0.7 10.1 14.1 0.43 10.7 12.5 1.6 2 0 0 2 2 1 0 Cleavage and polyadenylation factor 2 C-terminal Peptidase_S15 PF02129.18 CDI75634.1 - 0.72 9.4 12.0 0.92 9.0 12.0 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) AIF_C PF14721.6 CDI75634.1 - 0.79 10.1 13.7 1.1 9.7 12.7 1.8 2 0 0 2 2 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Peptidase_U57 PF05582.12 CDI75634.1 - 0.86 8.8 10.9 1.1 8.5 10.9 1.1 1 0 0 1 1 1 0 YabG peptidase U57 DUF2232 PF09991.9 CDI75634.1 - 1 8.5 7.5 1.6 7.8 7.5 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) ALMT PF11744.8 CDI75634.1 - 1.3 7.8 11.7 1.5 7.6 11.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Eapp_C PF10238.9 CDI75634.1 - 1.4 9.0 17.2 2.6 8.1 17.2 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF719 PF05334.13 CDI75634.1 - 1.7 8.8 19.8 0.12 12.6 14.9 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF719) Connexin PF00029.19 CDI75634.1 - 1.9 8.2 12.0 2.7 7.7 12.0 1.2 1 0 0 1 1 1 0 Connexin Pox_G7 PF05503.12 CDI75634.1 - 2.5 7.0 7.3 3.2 6.6 7.3 1.1 1 0 0 1 1 1 0 Poxvirus G7-like 2HCT PF03390.15 CDI75634.1 - 2.6 6.6 5.6 3.7 6.1 5.6 1.3 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family PBP_sp32 PF07222.12 CDI75634.1 - 2.7 7.4 15.6 3.3 7.1 15.6 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF913 PF06025.12 CDI75634.1 - 2.7 6.9 16.0 0.73 8.7 13.2 1.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) AAT PF03417.16 CDI75634.1 - 2.7 7.6 10.5 3.5 7.2 10.5 1.2 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase F-protein PF00469.20 CDI75634.1 - 2.8 7.5 12.3 3.7 7.1 12.3 1.2 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Hid1 PF12722.7 CDI75634.1 - 2.9 5.9 15.5 2.9 5.9 15.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein U3_snoRNA_assoc PF08297.11 CDI75634.1 - 3 8.6 11.8 5.1 7.9 11.8 1.4 1 0 0 1 1 1 0 U3 snoRNA associated Med15 PF09606.10 CDI75634.1 - 3.4 6.2 38.3 4.4 5.9 38.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal R_equi_Vir PF05526.11 CDI75634.1 - 3.5 7.4 12.8 5.9 6.7 12.8 1.4 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein EPL1 PF10513.9 CDI75634.1 - 3.9 7.8 20.9 4.4 7.7 18.8 1.9 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF2126 PF09899.9 CDI75634.1 - 3.9 5.4 10.6 4.1 5.4 10.6 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Usp PF00582.26 CDI75634.1 - 4 7.9 7.9 5.5 7.5 7.9 1.3 1 0 0 1 1 1 0 Universal stress protein family HCO3_cotransp PF00955.21 CDI75634.1 - 4.3 6.0 6.2 5.6 5.7 6.2 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF4179 PF13786.6 CDI75634.1 - 4.4 7.8 10.3 7.7 7.1 10.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) FAM176 PF14851.6 CDI75634.1 - 4.5 6.9 9.7 7.8 6.1 9.7 1.4 1 0 0 1 1 1 0 FAM176 family PPP4R2 PF09184.11 CDI75634.1 - 5 6.6 14.6 6.7 6.2 14.6 1.2 1 0 0 1 1 1 0 PPP4R2 RskA PF10099.9 CDI75634.1 - 5.6 7.2 27.4 18 5.6 27.5 1.7 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF853 PF05872.12 CDI75634.1 - 5.7 5.4 15.0 6.7 5.2 15.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) XRN_M PF17846.1 CDI75634.1 - 5.9 5.7 12.2 6.9 5.5 12.2 1.1 1 0 0 1 1 1 0 Xrn1 helical domain DUF3408 PF11888.8 CDI75634.1 - 6.2 7.0 18.2 9.8 6.3 18.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF2828 PF11443.8 CDI75634.1 - 6.2 4.8 15.9 8.1 4.4 15.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) NARP1 PF12569.8 CDI75634.1 - 7 5.4 17.0 2 7.2 14.5 1.3 2 0 0 2 2 1 0 NMDA receptor-regulated protein 1 DUF4746 PF15928.5 CDI75634.1 - 7.4 5.9 13.1 9.4 5.6 13.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) LMBR1 PF04791.16 CDI75634.1 - 7.5 5.3 7.0 8 5.2 7.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Rxt3 PF08642.10 CDI75634.1 - 8.1 7.2 11.7 0.72 10.6 7.1 1.7 2 0 0 2 2 1 0 Histone deacetylation protein Rxt3 Pkinase_fungal PF17667.1 CDI75634.1 - 8.5 5.0 11.8 12 4.6 11.8 1.2 1 0 0 1 1 1 0 Fungal protein kinase Cellulose_synt PF03552.14 CDI75634.1 - 9.2 4.6 5.9 11 4.4 5.9 1.1 1 0 0 1 1 1 0 Cellulose synthase O-antigen_lig PF13425.6 CDI75634.1 - 9.2 4.9 6.3 11 4.6 6.3 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Scs3p PF10261.9 CDI75634.1 - 9.6 5.6 7.1 97 2.3 7.0 2.0 2 0 0 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM Membralin PF09746.9 CDI75634.1 - 10 5.1 10.5 13 4.7 10.5 1.2 1 0 0 1 1 1 0 Tumour-associated protein PGI PF00342.19 CDI75635.1 - 6.1e-99 331.8 0.0 7.3e-99 331.6 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase DER1 PF04511.15 CDI75636.1 - 2.2e-43 148.4 15.3 2.5e-43 148.2 15.3 1.0 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 CDI75636.1 - 1.8e-06 28.1 15.6 2.7e-06 27.4 15.6 1.3 1 0 0 1 1 1 1 Rhomboid family Connexin PF00029.19 CDI75638.1 - 0.021 14.6 3.1 0.021 14.6 3.1 1.8 2 0 0 2 2 2 0 Connexin Serinc PF03348.15 CDI75638.1 - 9.7 5.0 7.5 0.31 9.9 0.8 1.7 2 0 0 2 2 2 0 Serine incorporator (Serinc) SMC_N PF02463.19 CDI75640.1 - 2.1e-06 27.3 0.5 0.00025 20.5 0.2 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDI75640.1 - 0.0063 17.0 0.0 0.01 16.4 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 CDI75640.1 - 0.0076 16.1 0.2 0.011 15.5 0.2 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system Shadoo PF14999.6 CDI75640.1 - 0.37 10.9 11.9 0.66 10.1 11.9 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective Ribosomal_60s PF00428.19 CDI75640.1 - 4.5 7.9 15.4 7.5 7.2 15.4 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein TMEM51 PF15345.6 CDI75642.1 - 0.0042 17.0 3.1 0.0042 17.0 3.1 2.5 2 1 0 2 2 2 1 Transmembrane protein 51 DUF4834 PF16118.5 CDI75642.1 - 0.25 12.3 21.2 0.53 11.3 1.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 CDI75642.1 - 0.26 12.2 0.4 0.26 12.2 0.4 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Conotoxin PF02950.17 CDI75642.1 - 0.48 11.5 11.9 0.57 11.2 0.6 3.1 2 0 0 2 2 2 0 Conotoxin GRP PF07172.11 CDI75642.1 - 0.73 10.6 5.7 0.96 10.2 0.1 2.3 2 0 0 2 2 2 0 Glycine rich protein family FAM176 PF14851.6 CDI75642.1 - 1.9 8.1 11.7 4.1 7.0 0.2 2.2 2 0 0 2 2 2 0 FAM176 family MMR1 PF08505.10 CDI75642.1 - 2.4 8.4 25.1 0.94 9.7 12.7 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein eIF-3_zeta PF05091.12 CDI75642.1 - 3.4 6.6 22.8 1.6 7.7 1.2 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4647 PF15504.6 CDI75642.1 - 4.9 6.1 19.9 0.27 10.3 6.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) Peptidase_S49_N PF08496.10 CDI75642.1 - 7.5 6.6 13.8 10 6.2 3.8 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF1764 PF08576.10 CDI75642.1 - 7.7 7.5 12.4 43 5.1 0.1 2.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) dsRBD2 PF17842.1 CDI75642.1 - 8.2 6.6 15.6 5.5 7.2 9.8 2.2 2 0 0 2 2 2 0 Double-stranded RNA binding domain 2 DUF4638 PF15472.6 CDI75642.1 - 9.4 5.9 13.7 4.9 6.8 7.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) ESM4 PF15952.5 CDI75642.1 - 9.5 6.6 28.1 0.24 11.8 5.2 2.1 2 0 0 2 2 2 0 Enhancer of split M4 family Mto2_bdg PF12808.7 CDI75643.1 - 0.0019 18.4 1.9 0.48 10.7 1.9 2.6 2 0 0 2 2 2 1 Micro-tubular organiser Mto1 C-term Mto2-binding region SHE3 PF17078.5 CDI75643.1 - 0.0078 16.0 0.9 0.013 15.3 0.9 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 YojJ PF10372.9 CDI75643.1 - 0.039 14.0 1.5 0.079 13.1 1.5 1.5 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus TMCO5 PF14992.6 CDI75643.1 - 0.072 12.7 1.0 0.12 12.0 1.0 1.2 1 0 0 1 1 1 0 TMCO5 family KASH_CCD PF14662.6 CDI75643.1 - 0.076 12.8 3.6 0.13 12.1 3.6 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH bZIP_1 PF00170.21 CDI75643.1 - 0.16 12.1 2.3 0.32 11.1 2.3 1.5 1 0 0 1 1 1 0 bZIP transcription factor DUF4094 PF13334.6 CDI75643.1 - 0.51 10.8 1.8 1.2 9.6 1.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) TPR_MLP1_2 PF07926.12 CDI75643.1 - 1 9.4 9.7 0.09 12.8 2.8 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Glt_symporter PF03616.14 CDI75644.1 - 0.0065 15.2 0.7 0.0065 15.2 0.7 4.4 3 1 0 3 3 3 1 Sodium/glutamate symporter DUF3824 PF12868.7 CDI75644.1 - 0.029 15.0 2.8 0.029 15.0 2.8 8.4 4 2 3 7 7 7 0 Domain of unknwon function (DUF3824) FeoB_associated PF12669.7 CDI75644.1 - 8.1 6.9 10.5 0.32 11.4 0.7 3.3 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein DUF2722 PF10846.8 CDI75645.1 - 1.1e-05 24.6 0.1 1.1e-05 24.6 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Apt1 PF10351.9 CDI75645.1 - 0.032 13.1 10.0 0.03 13.2 5.9 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain TFIIA PF03153.13 CDI75645.1 - 0.073 13.1 89.2 0.016 15.2 85.6 2.0 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4551 PF15087.6 CDI75645.1 - 0.17 10.7 22.1 0.29 9.9 22.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) ALMT PF11744.8 CDI75645.1 - 0.28 10.0 10.9 0.45 9.3 10.9 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 CDI75645.1 - 0.3 9.3 13.6 0.54 8.5 13.6 1.4 1 0 0 1 1 1 0 CDC45-like protein AAA_23 PF13476.6 CDI75645.1 - 0.43 11.0 19.6 0.7 10.4 19.6 1.3 1 0 0 1 1 1 0 AAA domain PAT1 PF09770.9 CDI75645.1 - 0.44 8.8 48.6 0.66 8.2 48.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MDM10 PF12519.8 CDI75645.1 - 1 8.1 14.5 1.9 7.2 14.5 1.5 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SLC12 PF03522.15 CDI75645.1 - 1.2 8.1 21.0 1.8 7.5 21.0 1.3 1 0 0 1 1 1 0 Solute carrier family 12 SOBP PF15279.6 CDI75645.1 - 1.4 9.5 35.8 0.45 11.1 32.0 1.9 2 0 0 2 2 2 0 Sine oculis-binding protein Presenilin PF01080.17 CDI75646.1 - 4.6e-06 25.7 21.4 5.4e-06 25.4 21.4 1.1 1 0 0 1 1 1 1 Presenilin SLC12 PF03522.15 CDI75646.1 - 0.00035 19.7 23.5 0.00038 19.6 23.5 1.1 1 0 0 1 1 1 1 Solute carrier family 12 Lin-8 PF03353.15 CDI75646.1 - 0.00039 20.1 23.5 0.0004 20.0 23.5 1.1 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist Hamartin PF04388.12 CDI75646.1 - 0.00095 18.0 17.7 0.001 17.8 17.7 1.1 1 0 0 1 1 1 1 Hamartin protein DUF4407 PF14362.6 CDI75646.1 - 0.001 18.5 25.3 0.0017 17.8 25.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.12 CDI75646.1 - 0.0018 18.1 23.7 0.0023 17.8 23.7 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 CDI75646.1 - 0.0029 15.8 21.6 0.0033 15.6 21.6 1.1 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Zip PF02535.22 CDI75646.1 - 0.0044 16.3 6.6 0.0044 16.3 6.6 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Neur_chan_memb PF02932.16 CDI75646.1 - 0.0051 16.9 15.6 0.0066 16.5 15.6 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF572 PF04502.13 CDI75646.1 - 0.021 14.4 18.6 0.027 14.1 18.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Mem_trans PF03547.18 CDI75646.1 - 0.028 12.8 4.7 0.036 12.5 4.7 1.2 1 0 0 1 1 1 0 Membrane transport protein Smg8_Smg9 PF10220.9 CDI75646.1 - 0.034 12.5 22.8 0.042 12.2 22.8 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Membralin PF09746.9 CDI75646.1 - 0.036 13.1 14.3 0.049 12.7 14.3 1.4 1 0 0 1 1 1 0 Tumour-associated protein Exonuc_VII_L PF02601.15 CDI75646.1 - 0.065 12.8 28.7 0.067 12.7 28.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peroxin-3 PF04882.12 CDI75646.1 - 0.067 12.2 25.9 0.088 11.8 25.9 1.2 1 0 0 1 1 1 0 Peroxin-3 Glyco_transf_41 PF13844.6 CDI75646.1 - 0.074 11.5 13.8 0.092 11.2 13.8 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 SID-1_RNA_chan PF13965.6 CDI75646.1 - 0.087 11.2 12.2 0.12 10.8 12.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Bul1_N PF04425.12 CDI75646.1 - 0.17 10.6 19.7 0.26 10.0 19.7 1.3 1 0 0 1 1 1 0 Bul1 N terminus DUF2052 PF09747.9 CDI75646.1 - 0.24 11.5 27.1 0.33 11.1 27.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) MRP-S26 PF14943.6 CDI75646.1 - 0.24 11.3 30.3 0.41 10.5 30.3 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 DUF4045 PF13254.6 CDI75646.1 - 0.35 10.5 23.1 0.45 10.1 23.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Ndc1_Nup PF09531.10 CDI75646.1 - 0.47 9.1 25.8 0.54 8.9 25.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup LMBR1 PF04791.16 CDI75646.1 - 0.5 9.2 17.6 0.64 8.9 17.6 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4776 PF16003.5 CDI75646.1 - 0.5 9.3 24.2 0.62 9.0 24.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) LAP1C PF05609.12 CDI75646.1 - 0.52 9.3 27.4 0.61 9.1 27.4 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Dapper PF15268.6 CDI75646.1 - 0.54 9.0 33.9 0.62 8.8 33.9 1.0 1 0 0 1 1 1 0 Dapper CDC45 PF02724.14 CDI75646.1 - 0.65 8.2 23.9 0.91 7.7 23.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Endostatin PF06482.11 CDI75646.1 - 0.66 9.4 26.2 0.87 9.0 26.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin HCO3_cotransp PF00955.21 CDI75646.1 - 0.66 8.7 9.5 0.83 8.4 9.5 1.2 1 0 0 1 1 1 0 HCO3- transporter family DUF1501 PF07394.12 CDI75646.1 - 0.67 8.9 22.2 0.76 8.8 22.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) PAT1 PF09770.9 CDI75646.1 - 0.7 8.1 52.2 0.87 7.8 52.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AAA_11 PF13086.6 CDI75646.1 - 0.86 9.3 28.4 1.1 9.0 28.4 1.1 1 0 0 1 1 1 0 AAA domain GET2 PF08690.10 CDI75646.1 - 0.92 9.1 32.3 1.2 8.7 32.3 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Paf1 PF03985.13 CDI75646.1 - 1 8.3 29.0 1.5 7.7 29.0 1.3 1 0 0 1 1 1 0 Paf1 Senescence_reg PF04520.13 CDI75646.1 - 1.2 9.9 18.3 2.2 9.1 18.3 1.4 1 0 0 1 1 1 0 Senescence regulator Peptidase_S46 PF10459.9 CDI75646.1 - 1.6 7.3 23.3 1.8 7.1 23.3 1.0 1 0 0 1 1 1 0 Peptidase S46 HSP70 PF00012.20 CDI75646.1 - 1.8 6.6 19.3 2.1 6.4 19.3 1.1 1 0 0 1 1 1 0 Hsp70 protein LicD PF04991.13 CDI75646.1 - 2.1 8.4 10.9 2.8 8.0 10.9 1.2 1 0 0 1 1 1 0 LicD family BPL_N PF09825.9 CDI75646.1 - 2.2 7.3 18.1 2.9 6.9 18.1 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Auxin_canalis PF05703.11 CDI75646.1 - 2.2 8.1 14.0 3.2 7.6 14.0 1.3 1 0 0 1 1 1 0 Auxin canalisation NARP1 PF12569.8 CDI75646.1 - 4.6 6.0 31.3 36 3.1 31.3 1.9 1 1 0 1 1 1 0 NMDA receptor-regulated protein 1 GAGA_bind PF06217.12 CDI75646.1 - 5.5 7.2 24.8 7 6.8 24.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Cellulose_synt PF03552.14 CDI75646.1 - 6.8 5.0 10.0 9 4.6 10.0 1.3 1 0 0 1 1 1 0 Cellulose synthase DUF913 PF06025.12 CDI75646.1 - 7.7 5.4 20.1 22 3.9 20.1 1.7 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) XRN_M PF17846.1 CDI75646.1 - 8.2 5.3 25.0 11 4.8 25.0 1.1 1 0 0 1 1 1 0 Xrn1 helical domain AlaDh_PNT_N PF05222.15 CDI75647.1 - 7.3e-22 78.1 0.0 8.8e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain XRN_N PF03159.18 CDI75647.1 - 0.12 11.8 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus Utp14 PF04615.13 CDI75648.1 - 0.56 8.7 46.3 0.71 8.4 46.3 1.1 1 0 0 1 1 1 0 Utp14 protein SR-25 PF10500.9 CDI75648.1 - 4.1 7.0 50.7 0.22 11.1 29.1 2.7 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein SR-25 PF10500.9 CDI75649.1 - 0.0056 16.3 12.0 0.0056 16.3 12.0 7.7 7 3 1 8 8 8 1 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI75649.1 - 0.0084 16.4 1.2 0.0084 16.4 1.2 8.8 4 2 3 7 7 7 4 Anti-sigma-K factor rskA CitMHS PF03600.16 CDI75650.1 - 0.00025 20.3 0.3 0.00025 20.3 0.3 5.3 4 2 0 4 4 4 1 Citrate transporter Adaptin_binding PF10199.9 CDI75650.1 - 0.0033 18.0 6.7 0.0033 18.0 6.7 10.8 5 3 5 10 10 10 2 Alpha and gamma adaptin binding protein p34 SR-25 PF10500.9 CDI75651.1 - 0.009 15.6 39.4 0.009 15.6 39.4 3.1 1 1 2 3 3 3 1 Nuclear RNA-splicing-associated protein Holin_2-3 PF13272.6 CDI75651.1 - 0.088 13.1 0.4 0.088 13.1 0.4 4.4 2 2 1 3 3 3 0 Putative 2/3 transmembrane domain holin Utp14 PF04615.13 CDI75651.1 - 1.6 7.2 82.8 2.1 6.8 82.8 1.1 1 0 0 1 1 1 0 Utp14 protein RAP1 PF07218.11 CDI75652.1 - 0.02 13.2 0.8 0.022 13.1 0.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4746 PF15928.5 CDI75652.1 - 0.048 13.1 20.3 0.087 12.2 20.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF2052 PF09747.9 CDI75652.1 - 0.21 11.7 26.9 0.29 11.3 26.9 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PAT1 PF09770.9 CDI75652.1 - 0.21 9.8 58.7 0.3 9.3 58.7 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MRP-S31 PF15433.6 CDI75652.1 - 0.65 9.6 35.6 0.89 9.2 35.6 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Utp14 PF04615.13 CDI75652.1 - 4.8 5.6 35.9 5.4 5.5 35.9 1.1 1 0 0 1 1 1 0 Utp14 protein Caldesmon PF02029.15 CDI75652.1 - 8.9 4.9 33.9 11 4.6 33.9 1.1 1 0 0 1 1 1 0 Caldesmon Sporozoite_P67 PF05642.11 CDI75653.1 - 1.1e-06 27.0 3.5 1.1e-06 27.0 3.5 10.1 3 3 7 10 10 10 1 Sporozoite P67 surface antigen Ribosomal_60s PF00428.19 CDI75653.1 - 0.0072 16.9 15.1 0.0072 16.9 15.1 13.9 8 3 4 13 13 13 2 60s Acidic ribosomal protein Mucin PF01456.17 CDI75653.1 - 0.016 15.2 0.0 0.016 15.2 0.0 7.9 8 2 1 9 9 9 0 Mucin-like glycoprotein His_Phos_1 PF00300.22 CDI75654.1 - 1.4e-08 34.7 11.0 7.2e-08 32.4 1.4 4.1 4 0 0 4 4 4 3 Histidine phosphatase superfamily (branch 1) DUF480 PF04337.12 CDI75654.1 - 0.065 13.3 5.6 0.17 12.0 5.6 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF480 Herpes_glycop PF01528.16 CDI75654.1 - 0.91 8.3 3.4 2.1 7.1 3.4 1.5 1 0 0 1 1 1 0 Herpesvirus glycoprotein M RskA PF10099.9 CDI75654.1 - 6.4 7.0 99.0 0.021 15.1 12.3 6.1 4 2 1 5 5 5 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI75655.1 - 8.4e-06 26.2 0.6 8.4e-06 26.2 0.6 3.3 1 1 1 2 2 2 1 Anti-sigma-K factor rskA RAP1 PF07218.11 CDI75655.1 - 0.065 11.5 19.5 0.069 11.4 19.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ketoacyl-synt PF00109.26 CDI75658.1 - 5.8e-127 422.5 0.3 1.1e-63 215.2 0.1 2.3 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CDI75658.1 - 1.6e-36 124.9 0.2 3.6e-36 123.8 0.2 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 CDI75658.1 - 2.1e-11 44.0 0.1 8.3e-10 38.9 0.0 2.8 3 0 0 3 3 3 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CDI75658.1 - 4e-06 27.3 0.0 9.7e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CDI75658.1 - 2.4e-05 23.8 6.2 0.0077 15.6 0.2 3.4 3 0 0 3 3 3 2 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CDI75658.1 - 0.01 15.7 0.2 0.01 15.7 0.2 3.1 4 0 0 4 4 4 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF1126 PF06565.12 CDI75659.1 - 6.2e-53 177.1 1.5 7.4e-27 93.2 0.0 3.7 4 0 0 4 4 4 3 DUF1126 PH-like domain EF-hand_1 PF00036.32 CDI75659.1 - 0.0022 17.4 0.1 0.0053 16.2 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 CDI75659.1 - 0.0023 18.3 0.0 0.0062 17.0 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 CDI75659.1 - 0.02 14.7 0.2 0.051 13.4 0.2 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 CDI75659.1 - 0.053 13.5 0.0 0.19 11.8 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain HEAT PF02985.22 CDI75659.1 - 1.8 9.0 10.3 7.5 7.1 0.1 5.6 5 0 0 5 5 5 0 HEAT repeat PIN_6 PF17146.4 CDI75660.1 - 2.2e-19 69.7 0.0 4.7e-19 68.7 0.0 1.6 1 0 0 1 1 1 1 PIN domain of ribonuclease Sigma70_ner PF04546.13 CDI75660.1 - 0.093 12.6 11.4 0.19 11.6 11.4 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region DNA_pol_phi PF04931.13 CDI75660.1 - 0.93 7.5 30.9 1.4 7.0 30.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 CDI75660.1 - 3.4 5.8 20.3 4.8 5.3 20.3 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 CDI75660.1 - 6.8 6.0 22.3 11 5.3 22.3 1.3 1 0 0 1 1 1 0 SDA1 EFTUD2 PF16004.5 CDI75663.1 - 7.1e-14 52.4 3.0 7.1e-14 52.4 3.0 4.6 3 2 1 4 4 4 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus GTP_EFTU PF00009.27 CDI75663.1 - 1.9e-06 27.5 0.2 5.9e-06 26.0 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF572 PF04502.13 CDI75663.1 - 0.0088 15.7 19.3 0.052 13.2 0.2 2.1 2 0 0 2 2 2 2 Family of unknown function (DUF572) Apt1 PF10351.9 CDI75663.1 - 0.12 11.2 27.4 0.21 10.4 9.3 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Presenilin PF01080.17 CDI75663.1 - 0.7 8.6 28.4 1.1 8.0 8.6 2.3 2 0 0 2 2 2 0 Presenilin DUF4776 PF16003.5 CDI75663.1 - 3 6.8 15.3 1.4 7.9 4.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) GREB1 PF15782.5 CDI75663.1 - 8.7 3.3 28.1 0.32 8.1 14.0 2.0 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer SR-25 PF10500.9 CDI75664.1 - 0.0031 17.2 14.5 0.0031 17.2 14.5 5.1 2 1 3 5 5 5 3 Nuclear RNA-splicing-associated protein Utp11 PF03998.13 CDI75666.1 - 2.3e-12 47.4 46.4 9e-12 45.4 46.4 2.0 1 1 0 1 1 1 1 Utp11 protein UPF0449 PF15136.6 CDI75666.1 - 0.0084 16.6 0.9 0.0084 16.6 0.9 3.7 4 0 0 4 4 4 1 Uncharacterised protein family UPF0449 K_channel_TID PF07941.11 CDI75666.1 - 0.037 14.5 8.1 0.037 14.5 8.1 6.4 3 2 1 4 4 4 0 Potassium channel Kv1.4 tandem inactivation domain DUF3390 PF11870.8 CDI75667.1 - 0.033 14.6 2.9 0.084 13.2 0.2 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3390) Neisseria_TspB PF05616.13 CDI75667.1 - 2.7 6.4 8.0 5.5 5.4 8.0 1.5 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein TFIIA PF03153.13 CDI75669.1 - 0.11 12.5 32.9 0.14 12.1 32.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2370 PF10176.9 CDI75669.1 - 0.14 11.8 3.3 0.2 11.3 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) MDM10 PF12519.8 CDI75669.1 - 0.9 8.3 8.1 1 8.2 8.1 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 V_ATPase_I PF01496.19 CDI75669.1 - 1.4 6.7 8.8 1.4 6.7 8.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MMR1 PF08505.10 CDI75669.1 - 1.6 9.0 12.5 1.7 8.8 12.5 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Membralin PF09746.9 CDI75669.1 - 2.2 7.2 6.0 2.5 7.1 6.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein BORG_CEP PF14957.6 CDI75669.1 - 2.3 9.4 9.7 3.5 8.8 9.7 1.2 1 0 0 1 1 1 0 Cdc42 effector Neur_chan_memb PF02932.16 CDI75669.1 - 2.6 8.1 8.5 2.8 8.0 8.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3464 PF11947.8 CDI75669.1 - 4.3 7.1 9.4 6.9 6.4 9.4 1.4 1 1 0 1 1 1 0 Photosynthesis affected mutant 68 Presenilin PF01080.17 CDI75669.1 - 4.3 6.0 12.1 4.8 5.8 12.1 1.1 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 CDI75669.1 - 4.4 6.8 7.6 5.4 6.5 7.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 ALMT PF11744.8 CDI75669.1 - 7 5.4 10.0 7.3 5.3 10.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SpoIIP PF07454.11 CDI75670.1 - 0.033 13.6 15.0 0.03 13.8 15.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CDC45 PF02724.14 CDI75670.1 - 0.046 12.0 14.3 0.043 12.1 14.3 1.0 1 0 0 1 1 1 0 CDC45-like protein EPL1 PF10513.9 CDI75670.1 - 0.11 12.9 13.5 0.12 12.7 13.5 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like Mem_trans PF03547.18 CDI75670.1 - 0.14 10.5 4.9 0.16 10.4 4.9 1.2 1 0 0 1 1 1 0 Membrane transport protein Spt5_N PF11942.8 CDI75670.1 - 0.17 12.9 19.2 0.051 14.6 16.5 1.6 2 0 0 2 2 1 0 Spt5 transcription elongation factor, acidic N-terminal Atg14 PF10186.9 CDI75670.1 - 0.31 10.1 22.3 0.29 10.2 22.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tim54 PF11711.8 CDI75670.1 - 0.35 9.6 17.4 0.39 9.4 17.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Sec62 PF03839.16 CDI75670.1 - 0.36 10.3 11.4 0.37 10.3 11.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Cellulose_synt PF03552.14 CDI75670.1 - 0.41 9.1 6.8 0.39 9.2 6.8 1.0 1 0 0 1 1 1 0 Cellulose synthase PTPRCAP PF15713.5 CDI75670.1 - 0.45 10.8 18.7 0.53 10.6 18.7 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Dynamin_N PF00350.23 CDI75670.1 - 0.45 10.5 7.2 0.52 10.4 7.2 1.2 1 0 0 1 1 1 0 Dynamin family SLC12 PF03522.15 CDI75670.1 - 0.54 9.2 16.1 0.5 9.3 16.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 FAM176 PF14851.6 CDI75670.1 - 0.55 9.9 10.5 0.68 9.6 10.5 1.2 1 0 0 1 1 1 0 FAM176 family Gti1_Pac2 PF09729.9 CDI75670.1 - 0.56 10.3 13.0 0.57 10.3 13.0 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4638 PF15472.6 CDI75670.1 - 0.59 9.8 14.7 0.58 9.8 14.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF4637 PF15470.6 CDI75670.1 - 0.63 9.8 11.2 0.79 9.4 11.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) ABC2_membrane_2 PF12679.7 CDI75670.1 - 0.65 9.2 7.6 0.79 8.9 7.6 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DDHD PF02862.17 CDI75670.1 - 0.88 9.7 14.8 0.92 9.6 14.8 1.2 1 0 0 1 1 1 0 DDHD domain BAF1_ABF1 PF04684.13 CDI75670.1 - 0.93 8.5 18.2 1.1 8.2 18.2 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FAM60A PF15396.6 CDI75670.1 - 0.96 9.4 11.0 0.89 9.5 11.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A MDM10 PF12519.8 CDI75670.1 - 0.99 8.2 13.8 0.99 8.2 13.8 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Tfb4 PF03850.14 CDI75670.1 - 1 8.8 11.2 1.2 8.6 11.2 1.1 1 0 0 1 1 1 0 Transcription factor Tfb4 NPR3 PF03666.13 CDI75670.1 - 1 8.1 14.0 1 8.1 14.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4770 PF15994.5 CDI75670.1 - 1.1 9.5 18.8 1.3 9.2 18.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Peptidase_S64 PF08192.11 CDI75670.1 - 1.1 7.6 12.2 1.1 7.7 12.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF4746 PF15928.5 CDI75670.1 - 1.1 8.6 11.5 1.1 8.7 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TFIIA PF03153.13 CDI75670.1 - 1.1 9.1 43.1 1.2 9.0 43.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3807 PF12720.7 CDI75670.1 - 1.2 9.4 26.1 1.4 9.2 26.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Presenilin PF01080.17 CDI75670.1 - 1.5 7.5 21.9 1.4 7.6 21.9 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 CDI75670.1 - 1.7 7.4 15.1 1.7 7.4 15.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter MMR1 PF08505.10 CDI75670.1 - 2.1 8.6 20.3 2 8.6 20.3 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Lin-8 PF03353.15 CDI75670.1 - 2.1 7.8 21.7 2.1 7.8 21.7 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist LptF_LptG PF03739.14 CDI75670.1 - 2.5 6.8 8.2 3.3 6.5 8.2 1.0 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG NACHT_N PF17100.5 CDI75670.1 - 3 7.7 19.2 3.6 7.4 19.2 1.2 1 0 0 1 1 1 0 N-terminal domain of NWD NACHT-NTPase DUF2151 PF10221.9 CDI75670.1 - 3 6.3 10.9 3 6.3 10.9 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator RR_TM4-6 PF06459.12 CDI75670.1 - 3.1 7.5 20.9 3.4 7.4 20.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GOLD_2 PF13897.6 CDI75670.1 - 3.5 8.1 5.4 4.8 7.7 5.4 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking FAM91_C PF14648.6 CDI75670.1 - 3.6 6.3 9.4 3.8 6.2 9.4 1.1 1 0 0 1 1 1 0 FAM91 C-terminus PPL5 PF18168.1 CDI75670.1 - 4.1 6.6 12.9 4.5 6.5 12.9 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Band_3_cyto PF07565.13 CDI75670.1 - 4.2 7.1 16.0 4.5 7.0 16.0 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Afi1 PF07792.12 CDI75670.1 - 4.4 7.8 17.8 5.9 7.4 17.8 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Otopetrin PF03189.13 CDI75670.1 - 5 5.8 9.4 4.8 5.9 9.4 1.1 1 0 0 1 1 1 0 Otopetrin Scs3p PF10261.9 CDI75670.1 - 5.2 6.5 6.1 5.3 6.5 6.1 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Endostatin PF06482.11 CDI75670.1 - 5.4 6.4 16.8 6 6.2 16.8 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Membralin PF09746.9 CDI75670.1 - 5.9 5.8 11.6 6 5.8 11.6 1.0 1 0 0 1 1 1 0 Tumour-associated protein hDGE_amylase PF14701.6 CDI75670.1 - 7.2 5.6 11.0 7.5 5.5 11.0 1.0 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain GREB1 PF15782.5 CDI75670.1 - 7.7 3.5 20.6 7.6 3.5 20.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PA26 PF04636.13 CDI75670.1 - 7.9 5.3 15.5 8.2 5.2 15.5 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Paramyxo_ncap PF00973.19 CDI75670.1 - 8.8 5.1 13.4 8.4 5.2 13.4 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein EOS1 PF12326.8 CDI75670.1 - 9 6.2 11.1 12 5.8 11.1 1.2 1 0 0 1 1 1 0 N-glycosylation protein Tho2 PF11262.8 CDI75670.1 - 9.8 5.3 17.6 10 5.2 17.6 1.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF2722 PF10846.8 CDI75672.1 - 0.00028 20.0 20.6 0.00028 20.0 20.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI75672.1 - 0.00072 20.2 17.1 0.00097 19.8 17.1 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PIP5K PF01504.18 CDI75672.1 - 0.0017 17.6 4.6 0.0018 17.6 4.6 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Suf PF05843.14 CDI75672.1 - 0.0019 18.3 15.4 0.0021 18.1 15.4 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) RICTOR_N PF14664.6 CDI75672.1 - 0.0019 17.3 6.1 0.0021 17.1 6.1 1.0 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term TFIIA PF03153.13 CDI75672.1 - 0.0078 16.3 29.8 0.0087 16.1 29.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit LAP1C PF05609.12 CDI75672.1 - 0.011 14.9 10.0 0.012 14.7 10.0 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Orf78 PF06024.12 CDI75672.1 - 0.012 15.9 2.6 0.019 15.2 2.6 1.4 1 0 0 1 1 1 0 Orf78 (ac78) SpoIIP PF07454.11 CDI75672.1 - 0.016 14.7 8.2 0.017 14.6 8.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Med15 PF09606.10 CDI75672.1 - 0.023 13.4 24.6 0.025 13.3 24.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CTNNB1_binding PF08347.11 CDI75672.1 - 0.03 14.5 7.5 0.033 14.4 7.5 1.1 1 0 0 1 1 1 0 N-terminal CTNNB1 binding Coiled-coil_56 PF09813.9 CDI75672.1 - 0.032 14.3 11.6 0.049 13.7 11.6 1.4 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 56 Presenilin PF01080.17 CDI75672.1 - 0.036 12.9 11.0 0.04 12.7 11.0 1.2 1 0 0 1 1 1 0 Presenilin Peptidase_U57 PF05582.12 CDI75672.1 - 0.036 13.3 5.4 0.037 13.3 5.4 1.0 1 0 0 1 1 1 0 YabG peptidase U57 DUF2207 PF09972.9 CDI75672.1 - 0.038 12.8 0.4 0.047 12.5 0.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EPL1 PF10513.9 CDI75672.1 - 0.044 14.2 10.3 0.053 13.9 10.3 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like Connexin PF00029.19 CDI75672.1 - 0.044 13.5 6.4 0.053 13.3 6.4 1.1 1 0 0 1 1 1 0 Connexin DUF3292 PF11696.8 CDI75672.1 - 0.045 12.1 8.3 0.053 11.9 8.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF913 PF06025.12 CDI75672.1 - 0.056 12.4 5.4 0.061 12.3 5.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 CDI75672.1 - 0.065 13.1 10.3 0.077 12.8 10.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BAF1_ABF1 PF04684.13 CDI75672.1 - 0.075 12.1 10.4 0.083 11.9 10.4 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Rsc14 PF08586.10 CDI75672.1 - 0.08 13.8 6.1 0.11 13.3 6.1 1.4 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit Neurensin PF14927.6 CDI75672.1 - 0.081 12.6 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Neurensin Otopetrin PF03189.13 CDI75672.1 - 0.088 11.6 2.1 0.091 11.6 2.1 1.1 1 0 0 1 1 1 0 Otopetrin DUF1189 PF06691.11 CDI75672.1 - 0.094 12.3 0.0 0.1 12.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) DUF2126 PF09899.9 CDI75672.1 - 0.097 10.7 6.9 0.098 10.7 6.9 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Mcm10 PF09332.11 CDI75672.1 - 0.098 12.1 14.6 0.11 11.9 14.6 1.0 1 0 0 1 1 1 0 Mcm10 replication factor MFS_Mycoplasma PF07672.13 CDI75672.1 - 0.11 11.8 0.7 0.13 11.6 0.7 1.0 1 0 0 1 1 1 0 Mycoplasma MFS transporter DUF4175 PF13779.6 CDI75672.1 - 0.11 10.4 30.0 0.13 10.2 30.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DcuA_DcuB PF03605.14 CDI75672.1 - 0.11 11.4 1.8 0.13 11.1 1.8 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter CPP1-like PF11833.8 CDI75672.1 - 0.11 12.2 6.5 0.14 11.8 6.5 1.2 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like MecA PF05389.12 CDI75672.1 - 0.12 11.9 7.0 0.13 11.9 7.0 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) OATP PF03137.20 CDI75672.1 - 0.13 10.5 3.8 0.15 10.3 3.8 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2370 PF10176.9 CDI75672.1 - 0.13 11.9 3.1 0.16 11.6 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Spc7_N PF15402.6 CDI75672.1 - 0.13 10.4 10.9 0.17 10.1 10.9 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Peroxin-13_N PF04088.13 CDI75672.1 - 0.14 12.5 4.2 0.16 12.3 4.2 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region FAM176 PF14851.6 CDI75672.1 - 0.14 11.8 3.3 0.16 11.7 3.3 1.2 1 0 0 1 1 1 0 FAM176 family Glt_symporter PF03616.14 CDI75672.1 - 0.14 10.8 3.0 0.15 10.7 3.0 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter CSG2 PF16965.5 CDI75672.1 - 0.14 11.1 4.6 0.14 11.1 4.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Velvet PF11754.8 CDI75672.1 - 0.14 12.1 9.3 0.14 12.0 9.3 1.2 1 0 0 1 1 1 0 Velvet factor EIIBC-GUT_N PF03612.14 CDI75672.1 - 0.14 11.8 7.5 0.16 11.7 7.5 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Neur_chan_memb PF02932.16 CDI75672.1 - 0.15 12.1 7.5 0.16 12.0 7.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Band_3_cyto PF07565.13 CDI75672.1 - 0.15 11.8 9.0 0.16 11.7 9.0 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RED_N PF07808.13 CDI75672.1 - 0.17 11.4 11.7 0.2 11.2 11.7 1.2 1 0 0 1 1 1 0 RED-like protein N-terminal region AIF_C PF14721.6 CDI75672.1 - 0.2 12.0 7.1 0.26 11.6 7.1 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term MMR1 PF08505.10 CDI75672.1 - 0.2 11.9 12.8 0.2 11.9 12.8 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF2828 PF11443.8 CDI75672.1 - 0.22 9.6 8.6 0.22 9.6 8.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DDHD PF02862.17 CDI75672.1 - 0.22 11.6 8.9 0.22 11.6 8.9 1.1 1 0 0 1 1 1 0 DDHD domain PAT1 PF09770.9 CDI75672.1 - 0.26 9.5 20.0 0.26 9.5 20.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Gti1_Pac2 PF09729.9 CDI75672.1 - 0.29 11.2 7.2 0.3 11.1 7.2 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Renin_r PF07850.14 CDI75672.1 - 0.32 11.6 2.5 0.49 11.0 2.5 1.3 1 0 0 1 1 1 0 Renin receptor-like protein Consortin_C PF15281.6 CDI75672.1 - 0.33 11.0 2.8 0.44 10.6 2.8 1.2 1 0 0 1 1 1 0 Consortin C-terminus ABC2_membrane_2 PF12679.7 CDI75672.1 - 0.38 10.0 5.1 0.48 9.7 5.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF2839 PF10999.8 CDI75672.1 - 0.39 11.1 2.5 0.61 10.5 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2839) CrgA PF06781.12 CDI75672.1 - 0.39 10.8 2.8 0.76 9.9 2.8 1.6 1 1 0 1 1 1 0 Cell division protein CrgA Rxt3 PF08642.10 CDI75672.1 - 0.41 11.4 5.5 0.5 11.2 5.5 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 EOS1 PF12326.8 CDI75672.1 - 0.41 10.6 5.1 0.52 10.2 5.1 1.2 1 0 0 1 1 1 0 N-glycosylation protein DUF775 PF05603.12 CDI75672.1 - 0.43 10.1 11.5 0.48 9.9 11.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Membralin PF09746.9 CDI75672.1 - 0.48 9.4 5.1 0.5 9.4 5.1 1.0 1 0 0 1 1 1 0 Tumour-associated protein MMU163 PF17119.5 CDI75672.1 - 0.49 9.5 4.8 0.57 9.3 4.8 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Tim54 PF11711.8 CDI75672.1 - 0.61 8.8 11.9 0.72 8.6 11.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CLN3 PF02487.17 CDI75672.1 - 0.64 9.0 7.3 0.63 9.0 7.3 1.1 1 0 0 1 1 1 0 CLN3 protein MAJIN PF15077.6 CDI75672.1 - 0.69 9.7 6.7 0.76 9.5 6.7 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein MDM10 PF12519.8 CDI75672.1 - 0.74 8.6 7.9 0.74 8.6 7.9 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Het-C PF07217.11 CDI75672.1 - 0.8 8.2 7.3 0.88 8.0 7.3 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C V_ATPase_I PF01496.19 CDI75672.1 - 0.85 7.5 10.5 0.91 7.4 10.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2347 PF09804.9 CDI75672.1 - 0.86 9.1 6.8 1.1 8.8 6.8 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) MDM31_MDM32 PF08118.11 CDI75672.1 - 0.87 8.2 6.7 0.94 8.1 6.7 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Sec62 PF03839.16 CDI75672.1 - 0.91 9.0 6.7 1.1 8.8 6.7 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 ALMT PF11744.8 CDI75672.1 - 0.94 8.2 6.7 0.95 8.2 6.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Ndc1_Nup PF09531.10 CDI75672.1 - 1.1 7.9 11.1 1.2 7.7 11.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Plasmodium_Vir PF05795.11 CDI75672.1 - 1.2 8.5 5.7 1.1 8.6 5.7 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein FAM60A PF15396.6 CDI75672.1 - 1.2 9.1 9.1 1.6 8.7 9.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A LMBR1 PF04791.16 CDI75672.1 - 1.4 7.8 4.3 1.4 7.7 4.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Ctr PF04145.15 CDI75672.1 - 1.7 9.3 7.2 2 9.0 7.2 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Spt20 PF12090.8 CDI75672.1 - 1.9 8.1 40.9 2.7 7.5 40.9 1.3 1 0 0 1 1 1 0 Spt20 family FHIPEP PF00771.20 CDI75672.1 - 2.4 6.5 10.7 2.7 6.4 10.7 1.0 1 0 0 1 1 1 0 FHIPEP family Hid1 PF12722.7 CDI75672.1 - 2.4 6.2 11.5 2.7 6.0 11.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4366 PF14283.6 CDI75672.1 - 2.4 8.2 9.0 5.1 7.1 9.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) Serinc PF03348.15 CDI75672.1 - 2.6 6.9 7.1 3 6.7 7.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Gastrin PF00918.17 CDI75672.1 - 2.9 8.9 11.6 3.8 8.5 11.6 1.3 1 0 0 1 1 1 0 Gastrin/cholecystokinin family DUF3464 PF11947.8 CDI75672.1 - 3 7.6 13.3 4.1 7.1 13.3 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Roughex PF06020.11 CDI75672.1 - 3.1 6.8 15.3 3.8 6.5 15.3 1.2 1 0 0 1 1 1 0 Drosophila roughex protein PigN PF04987.14 CDI75672.1 - 3.3 6.5 7.5 4.1 6.2 7.5 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Kei1 PF08552.11 CDI75672.1 - 3.4 7.5 12.1 4.9 7.0 12.1 1.4 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 UPF0560 PF10577.9 CDI75672.1 - 4.3 5.7 20.1 4.4 5.7 20.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 60KD_IMP PF02096.20 CDI75672.1 - 5.6 6.8 12.7 7.2 6.5 12.7 1.2 1 0 0 1 1 1 0 60Kd inner membrane protein SID-1_RNA_chan PF13965.6 CDI75672.1 - 6.3 5.1 6.2 7.1 4.9 6.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TERB2 PF15101.6 CDI75672.1 - 7 6.6 19.4 9.4 6.2 19.4 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 ABC2_membrane_3 PF12698.7 CDI75672.1 - 7.1 5.6 6.7 9.6 5.2 6.7 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4834 PF16118.5 CDI75672.1 - 8.5 7.4 17.9 14 6.7 17.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CDP-OH_P_transf PF01066.21 CDI75673.1 - 6.5e-11 42.8 1.5 6.5e-11 42.8 1.5 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Presenilin PF01080.17 CDI75673.1 - 0.00088 18.1 0.6 0.00088 18.1 0.6 1.7 2 0 0 2 2 2 1 Presenilin Apt1 PF10351.9 CDI75673.1 - 0.038 12.9 17.5 0.053 12.4 17.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 CDI75673.1 - 0.088 12.7 18.1 0.14 12.0 18.1 1.3 1 0 0 1 1 1 0 SPX domain MnhB PF04039.13 CDI75673.1 - 0.64 10.3 11.1 0.77 10.1 2.0 3.0 3 0 0 3 3 3 0 Domain related to MnhB subunit of Na+/H+ antiporter Apt1 PF10351.9 CDI75674.1 - 0.0096 14.8 9.1 0.012 14.5 9.1 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain Cyt_bd_oxida_II PF02322.15 CDI75674.1 - 0.078 12.3 17.3 0.098 12.0 17.3 1.1 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II SR-25 PF10500.9 CDI75674.1 - 0.49 10.0 40.1 1.7 8.2 19.7 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein ANAPC1 PF12859.7 CDI75674.1 - 0.53 10.9 7.7 2.4 8.7 1.5 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 IMUP PF15761.5 CDI75674.1 - 1 10.1 33.7 0.37 11.5 13.6 2.3 2 0 0 2 2 2 0 Immortalisation up-regulated protein LMF1 PF06762.14 CDI75674.1 - 1.2 8.2 5.8 1.3 8.1 5.8 1.1 1 0 0 1 1 1 0 Lipase maturation factor DUF4834 PF16118.5 CDI75674.1 - 2 9.4 5.0 21 6.2 1.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CCDC106 PF15794.5 CDI75674.1 - 2.5 7.7 15.4 2.3 7.9 4.2 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Secretin_N_2 PF07655.13 CDI75674.1 - 8.1 7.1 31.3 1.5 9.4 9.9 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Metallophos PF00149.28 CDI75675.1 - 0.0068 16.9 0.1 0.015 15.8 0.1 1.5 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDI75675.1 - 0.14 12.7 0.1 0.55 10.7 0.1 1.9 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain DUF3246 PF11596.8 CDI75676.1 - 0.022 14.2 1.4 0.022 14.2 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Patatin PF01734.22 CDI75676.1 - 0.29 11.3 2.2 0.3 11.2 2.2 1.0 1 0 0 1 1 1 0 Patatin-like phospholipase BAF1_ABF1 PF04684.13 CDI75676.1 - 1.4 7.9 9.0 1.4 7.9 9.0 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Fibrillarin PF01269.17 CDI75677.1 - 8.1e-99 329.3 0.0 9.2e-99 329.1 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 CDI75677.1 - 0.00054 19.7 0.0 0.00081 19.1 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit DREV PF05219.12 CDI75677.1 - 0.04 13.0 0.0 0.057 12.5 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltr_RsmB-F PF01189.17 CDI75677.1 - 0.041 13.5 0.0 0.074 12.7 0.0 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 CDI75677.1 - 0.052 13.3 0.0 0.086 12.6 0.0 1.3 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 CDI75677.1 - 0.059 13.5 0.0 0.12 12.5 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase NUDIX-like PF09296.11 CDI75677.1 - 0.07 13.8 0.0 0.84 10.3 0.0 2.1 2 0 0 2 2 2 0 NADH pyrophosphatase-like rudimentary NUDIX domain HI0933_like PF03486.14 CDI75679.1 - 0.021 13.6 11.9 0.021 13.5 11.9 1.0 1 0 0 1 1 1 0 HI0933-like protein Prp18 PF02840.15 CDI75679.1 - 0.041 13.9 6.3 0.045 13.8 6.3 1.0 1 0 0 1 1 1 0 Prp18 domain WASH-7_mid PF14744.6 CDI75679.1 - 0.047 12.8 8.4 0.052 12.6 8.4 1.0 1 0 0 1 1 1 0 WASH complex subunit 7 DUF445 PF04286.12 CDI75679.1 - 0.048 13.5 6.1 0.049 13.4 6.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Pim PF16765.5 CDI75679.1 - 0.094 12.9 0.8 0.12 12.5 0.8 1.1 1 0 0 1 1 1 0 Pesticin immunity protein Trigger_C PF05698.14 CDI75679.1 - 0.29 11.1 18.5 0.32 11.0 18.5 1.0 1 0 0 1 1 1 0 Bacterial trigger factor protein (TF) C-terminus Ofd1_CTDD PF10637.9 CDI75679.1 - 0.46 9.8 8.1 0.48 9.7 8.1 1.1 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term DUF4407 PF14362.6 CDI75679.1 - 0.86 8.9 15.7 0.96 8.7 15.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tam41_Mmp37 PF09139.11 CDI75679.1 - 1 8.7 10.2 1.1 8.6 10.2 1.0 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial Exonuc_VII_L PF02601.15 CDI75679.1 - 1.6 8.2 17.3 1.7 8.1 17.3 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spore_II_R PF09551.10 CDI75679.1 - 1.7 9.1 6.9 2 8.9 6.9 1.2 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) YkuI_C PF10388.9 CDI75679.1 - 1.8 8.3 9.3 2.1 8.1 9.3 1.1 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain DUF668 PF05003.12 CDI75679.1 - 2 8.9 6.6 2.8 8.5 6.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF668) DUF3819 PF12842.7 CDI75679.1 - 2.6 8.0 18.0 1.3 9.0 9.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3819) Noggin PF05806.12 CDI75679.1 - 2.8 7.8 8.1 3.1 7.6 8.1 1.1 1 0 0 1 1 1 0 Noggin DUF2924 PF11149.8 CDI75679.1 - 3.2 8.1 9.7 3.8 7.9 9.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) FliP PF00813.20 CDI75679.1 - 3.6 7.4 6.3 4 7.3 6.3 1.1 1 0 0 1 1 1 0 FliP family AI-2E_transport PF01594.16 CDI75679.1 - 3.7 6.6 7.7 3.9 6.5 7.7 1.1 1 0 0 1 1 1 0 AI-2E family transporter CemA PF03040.14 CDI75679.1 - 4.7 7.1 8.3 5.1 7.0 8.3 1.1 1 0 0 1 1 1 0 CemA family PepSY_TM_like_2 PF16357.5 CDI75679.1 - 5.3 7.0 10.3 6.2 6.7 10.3 1.2 1 0 0 1 1 1 0 Putative PepSY_TM-like MotA_ExbB PF01618.16 CDI75679.1 - 5.4 6.8 8.5 21 4.9 8.5 1.8 1 1 0 1 1 1 0 MotA/TolQ/ExbB proton channel family TcA_TcB_BD PF18276.1 CDI75679.1 - 7.3 5.6 16.5 7.5 5.5 16.5 1.0 1 0 0 1 1 1 0 Tc toxin complex TcA C-terminal TcB-binding domain FHIPEP PF00771.20 CDI75679.1 - 7.5 4.9 11.4 7.5 4.9 11.4 1.0 1 0 0 1 1 1 0 FHIPEP family DUF2294 PF10057.9 CDI75679.1 - 7.6 6.7 13.9 2.1e+02 2.1 13.9 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) BTG PF07742.12 CDI75679.1 - 8.7 6.2 10.2 21 5.0 10.2 1.7 1 1 0 1 1 1 0 BTG family Mak16 PF04874.14 CDI75680.1 - 4.6e-18 65.7 18.7 4.6e-18 65.7 18.7 2.8 1 1 1 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 CDI75680.1 - 0.16 11.3 27.4 0.21 10.9 27.4 1.1 1 0 0 1 1 1 0 BUD22 DUF2457 PF10446.9 CDI75680.1 - 1.8 7.6 25.7 2.9 7.0 25.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BT1 PF03092.16 CDI75682.1 - 2.2e-76 257.2 24.6 3.7e-52 177.3 13.0 2.1 2 0 0 2 2 2 2 BT1 family DUF3561 PF12084.8 CDI75682.1 - 4.5 7.3 8.2 3.7 7.6 1.6 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3561) TFIIA PF03153.13 CDI75683.1 - 6.1e-08 33.1 51.2 1.5e-05 25.2 14.9 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI75683.1 - 6.8e-07 29.8 20.5 0.016 15.5 0.0 4.3 3 1 1 4 4 4 3 Anti-sigma-K factor rskA Med15 PF09606.10 CDI75683.1 - 0.0026 16.5 35.3 0.0027 16.5 7.9 2.5 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal SOG2 PF10428.9 CDI75683.1 - 0.013 14.8 68.4 0.037 13.2 31.5 2.0 2 0 0 2 2 2 0 RAM signalling pathway protein ANAPC_CDC26 PF10471.9 CDI75683.1 - 0.029 15.2 11.4 0.029 15.2 11.4 6.7 6 2 1 7 7 7 0 Anaphase-promoting complex APC subunit CDC26 PAT1 PF09770.9 CDI75683.1 - 0.83 7.9 28.8 0.52 8.5 3.0 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 FHIPEP PF00771.20 CDI75683.1 - 2.2 6.6 5.8 3.3 6.1 0.7 2.3 2 0 0 2 2 2 0 FHIPEP family MEIOC PF15189.6 CDI75683.1 - 8 6.0 9.9 0.56 9.8 1.9 2.5 2 0 0 2 2 2 0 Meiosis-specific coiled-coil domain-containing protein MEIOC Peptidase_S49_N PF08496.10 CDI75683.1 - 9.5 6.3 11.3 8.7 6.4 1.4 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal TMEM154 PF15102.6 CDI75684.1 - 1.9e-05 24.6 0.2 1.9e-05 24.6 0.2 4.1 3 1 0 3 3 1 1 TMEM154 protein family BatD PF13584.6 CDI75684.1 - 0.00021 20.2 3.5 0.00021 20.2 3.5 2.7 1 1 2 3 3 2 1 Oxygen tolerance DUF2207 PF09972.9 CDI75684.1 - 0.00024 20.0 0.3 0.00024 20.0 0.3 2.9 1 1 1 2 2 1 1 Predicted membrane protein (DUF2207) Tmemb_9 PF05434.11 CDI75684.1 - 0.00055 19.9 4.6 0.00055 19.9 4.6 3.8 3 1 1 4 4 1 1 TMEM9 Orf78 PF06024.12 CDI75684.1 - 0.0012 19.1 3.0 0.0012 19.1 3.0 4.8 3 2 1 4 4 3 1 Orf78 (ac78) DUF3169 PF11368.8 CDI75684.1 - 0.0016 18.0 1.3 0.0016 18.0 1.3 2.5 3 1 0 3 3 1 1 Protein of unknown function (DUF3169) GRP PF07172.11 CDI75684.1 - 0.0026 18.4 0.5 0.0026 18.4 0.5 5.0 4 1 0 4 4 3 1 Glycine rich protein family Presenilin PF01080.17 CDI75684.1 - 0.0035 16.2 11.7 0.0035 16.2 11.7 2.6 1 1 1 2 2 1 1 Presenilin Peptidase_M56 PF05569.11 CDI75684.1 - 0.0037 16.5 4.7 0.0037 16.5 4.7 1.6 1 1 0 1 1 1 1 BlaR1 peptidase M56 SAPS PF04499.15 CDI75684.1 - 0.0065 15.3 0.4 0.0065 15.3 0.4 2.3 1 1 1 2 2 1 1 SIT4 phosphatase-associated protein Pox_Ag35 PF03286.14 CDI75684.1 - 0.0068 16.2 0.4 0.0068 16.2 0.4 3.8 2 1 1 3 3 1 1 Pox virus Ag35 surface protein PPP4R2 PF09184.11 CDI75684.1 - 0.013 15.1 1.8 0.013 15.1 1.8 3.0 2 1 0 3 3 1 0 PPP4R2 Pex14_N PF04695.13 CDI75684.1 - 0.027 15.1 11.4 0.027 15.1 11.4 3.3 3 1 0 3 3 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region LRRC37AB_C PF14914.6 CDI75684.1 - 0.029 14.3 2.9 0.029 14.3 2.9 4.5 2 2 2 4 4 2 0 LRRC37A/B like protein 1 C-terminal domain E7 PF00527.18 CDI75684.1 - 0.042 14.1 1.8 0.042 14.1 1.8 5.1 3 1 0 3 3 2 0 E7 protein, Early protein DUF4064 PF13273.6 CDI75684.1 - 0.068 13.5 1.0 0.068 13.5 1.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF4064) Renin_r PF07850.14 CDI75684.1 - 0.087 13.4 0.8 0.087 13.4 0.8 4.6 2 2 1 3 3 2 0 Renin receptor-like protein Phage_Gp23 PF10669.9 CDI75684.1 - 0.11 12.9 0.4 0.11 12.9 0.4 5.9 1 1 4 5 5 2 0 Protein gp23 (Bacteriophage A118) RskA PF10099.9 CDI75684.1 - 0.12 12.6 8.8 0.38 11.0 8.8 2.0 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Frizzled PF01534.17 CDI75684.1 - 0.2 10.6 0.9 0.38 9.7 0.9 1.5 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region Wzy_C PF04932.15 CDI75684.1 - 0.26 10.9 0.0 1.2 8.8 0.0 2.2 1 1 0 1 1 1 0 O-Antigen ligase TAS2R PF05296.13 CDI75684.1 - 0.26 10.4 7.0 0.39 9.8 7.0 1.2 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) Trp_oprn_chp PF09534.10 CDI75684.1 - 0.32 10.8 0.0 0.32 10.8 0.0 1.8 2 1 0 2 2 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Gemini_mov PF01708.16 CDI75684.1 - 0.34 10.7 2.3 0.9 9.3 2.1 1.9 1 1 1 2 2 2 0 Geminivirus putative movement protein MAPEG PF01124.18 CDI75684.1 - 0.42 10.5 0.0 0.42 10.5 0.0 2.6 3 1 0 3 3 1 0 MAPEG family KCH PF16944.5 CDI75684.1 - 0.48 10.2 2.5 0.48 10.2 1.1 1.7 1 1 1 2 2 2 0 Fungal potassium channel DUF3357 PF11837.8 CDI75684.1 - 0.94 10.0 7.8 2.5 8.6 4.5 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) TFIIA PF03153.13 CDI75684.1 - 1.2 9.0 73.2 0.23 11.4 39.4 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit NicO PF03824.16 CDI75684.1 - 1.6 8.0 9.2 0.63 9.3 6.5 1.7 1 1 0 1 1 1 0 High-affinity nickel-transport protein TraG_N PF07916.11 CDI75684.1 - 2.8 6.7 3.7 4.2 6.1 3.7 1.2 1 0 0 1 1 1 0 TraG-like protein, N-terminal region PBP1_TM PF14812.6 CDI75684.1 - 9.3 6.7 0.0 6.8 7.1 0.4 4.4 4 0 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal OAD_gamma PF04277.13 CDI75684.1 - 9.9 6.8 0.0 9.9 6.8 0.0 5.8 3 2 1 4 4 2 0 Oxaloacetate decarboxylase, gamma chain RskA PF10099.9 CDI75685.1 - 0.0029 17.9 5.6 0.0033 17.7 5.6 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Phage_Gp23 PF10669.9 CDI75685.1 - 0.011 16.1 15.3 0.013 15.8 15.3 1.1 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) DUF1980 PF09323.10 CDI75685.1 - 0.024 14.5 8.6 0.03 14.2 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Myc_target_1 PF15179.6 CDI75685.1 - 0.027 14.4 3.7 0.034 14.1 3.7 1.1 1 0 0 1 1 1 0 Myc target protein 1 HGTP_anticodon2 PF12745.7 CDI75685.1 - 0.042 13.3 12.0 0.051 13.1 12.0 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Connexin PF00029.19 CDI75685.1 - 0.046 13.5 6.0 0.046 13.5 6.0 1.2 1 0 0 1 1 1 0 Connexin Chordopox_G3 PF06129.12 CDI75685.1 - 0.048 14.4 0.8 0.061 14.0 0.8 1.1 1 0 0 1 1 1 0 Chordopoxvirus G3 protein SpoIIP PF07454.11 CDI75685.1 - 0.049 13.1 8.9 0.05 13.1 8.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CPSF100_C PF13299.6 CDI75685.1 - 0.067 13.4 7.4 0.065 13.4 7.4 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2828 PF11443.8 CDI75685.1 - 0.07 11.2 13.6 0.086 10.9 13.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) ABC2_membrane_2 PF12679.7 CDI75685.1 - 0.075 12.3 4.8 0.08 12.2 4.8 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein RR_TM4-6 PF06459.12 CDI75685.1 - 0.077 12.8 10.2 0.07 12.9 10.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobT PF06213.12 CDI75685.1 - 0.079 12.3 14.8 0.084 12.3 14.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT eIF-3_zeta PF05091.12 CDI75685.1 - 0.079 11.9 15.7 0.077 12.0 15.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) O-antigen_lig PF13425.6 CDI75685.1 - 0.12 11.1 7.7 0.14 10.9 7.7 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein GDE_N PF12439.8 CDI75685.1 - 0.15 11.5 8.7 0.18 11.2 8.7 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme N terminal KASH PF10541.9 CDI75685.1 - 0.15 12.3 3.8 0.28 11.5 3.8 1.4 1 0 0 1 1 1 0 Nuclear envelope localisation domain FAM176 PF14851.6 CDI75685.1 - 0.19 11.4 6.4 0.26 10.9 6.4 1.2 1 0 0 1 1 1 0 FAM176 family Presenilin PF01080.17 CDI75685.1 - 0.23 10.2 13.3 0.25 10.1 13.3 1.1 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 CDI75685.1 - 0.28 9.8 7.9 0.3 9.7 7.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Scs3p PF10261.9 CDI75685.1 - 0.29 10.6 7.3 0.34 10.4 7.3 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Peptidase_S49_N PF08496.10 CDI75685.1 - 0.32 11.0 15.9 0.41 10.7 15.9 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SID-1_RNA_chan PF13965.6 CDI75685.1 - 0.4 9.0 6.0 0.47 8.8 6.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CLN3 PF02487.17 CDI75685.1 - 0.45 9.5 12.2 0.47 9.4 12.2 1.0 1 0 0 1 1 1 0 CLN3 protein DUF4834 PF16118.5 CDI75685.1 - 0.46 11.5 19.4 0.37 11.8 18.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) ALMT PF11744.8 CDI75685.1 - 0.5 9.1 9.3 0.47 9.2 9.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Serinc PF03348.15 CDI75685.1 - 0.53 9.1 7.4 0.58 9.0 7.4 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) EOS1 PF12326.8 CDI75685.1 - 0.59 10.1 5.8 0.64 9.9 5.8 1.2 1 0 0 1 1 1 0 N-glycosylation protein OATP PF03137.20 CDI75685.1 - 0.62 8.3 5.2 0.61 8.3 5.2 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DDHD PF02862.17 CDI75685.1 - 1.1 9.4 11.2 1.1 9.3 11.2 1.1 1 0 0 1 1 1 0 DDHD domain CSG2 PF16965.5 CDI75685.1 - 1.4 7.7 10.4 1.5 7.7 10.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator YABBY PF04690.13 CDI75685.1 - 1.4 9.4 10.8 1.6 9.3 10.8 1.1 1 0 0 1 1 1 0 YABBY protein Arm-DNA-bind_5 PF17293.2 CDI75685.1 - 1.5 9.3 10.4 2.1 8.8 10.4 1.3 1 0 0 1 1 1 0 Arm DNA-binding domain Pex14_N PF04695.13 CDI75685.1 - 1.6 9.4 18.9 0.21 12.3 15.5 1.3 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MMR1 PF08505.10 CDI75685.1 - 1.6 8.9 18.1 1.7 8.9 18.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Mlo PF03094.15 CDI75685.1 - 1.7 6.9 10.9 1.9 6.8 10.9 1.0 1 0 0 1 1 1 0 Mlo family DUF4746 PF15928.5 CDI75685.1 - 1.8 8.0 10.6 2 7.8 10.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TERB2 PF15101.6 CDI75685.1 - 1.8 8.6 17.8 2.1 8.4 17.8 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4446 PF14584.6 CDI75685.1 - 1.9 8.4 10.2 2.3 8.2 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Folate_carrier PF01770.18 CDI75685.1 - 2.1 7.0 7.0 2.3 6.9 7.0 1.1 1 0 0 1 1 1 0 Reduced folate carrier FliP PF00813.20 CDI75685.1 - 2.3 8.1 12.5 2.3 8.0 12.5 1.1 1 0 0 1 1 1 0 FliP family Gti1_Pac2 PF09729.9 CDI75685.1 - 2.4 8.2 10.8 2.7 8.1 10.8 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Asp-B-Hydro_N PF05279.11 CDI75685.1 - 2.7 8.0 11.5 3.2 7.7 11.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Band_3_cyto PF07565.13 CDI75685.1 - 3.1 7.5 16.5 3.3 7.4 16.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Ctr PF04145.15 CDI75685.1 - 3.5 8.3 8.4 4.2 8.0 8.4 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Sec62 PF03839.16 CDI75685.1 - 4 6.9 13.0 5.6 6.4 13.0 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2072 PF09845.9 CDI75685.1 - 4.6 7.5 12.5 6 7.1 12.5 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein Neur_chan_memb PF02932.16 CDI75685.1 - 4.6 7.2 10.9 5.1 7.1 10.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_S15 PF02129.18 CDI75685.1 - 5.5 6.5 11.3 5.8 6.4 11.3 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Endonuc_Holl PF10107.9 CDI75685.1 - 5.9 6.7 12.6 7.4 6.4 12.6 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Paramyxo_ncap PF00973.19 CDI75685.1 - 6.5 5.5 11.3 6.9 5.5 11.3 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein TFIIA PF03153.13 CDI75685.1 - 6.6 6.6 35.8 7.9 6.4 35.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_U57 PF05582.12 CDI75685.1 - 6.8 5.9 12.1 7.6 5.7 12.1 1.1 1 0 0 1 1 1 0 YabG peptidase U57 V_ATPase_I PF01496.19 CDI75685.1 - 7 4.4 21.6 7.6 4.3 21.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MPM1 PF17234.2 CDI75685.1 - 7.3 6.8 17.9 10 6.3 17.9 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 EIIBC-GUT_N PF03612.14 CDI75685.1 - 9.5 5.9 12.5 14 5.4 12.5 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus RskA PF10099.9 CDI75686.1 - 4.1e-07 30.5 35.7 1.2e-06 28.9 16.4 5.7 2 1 1 4 4 4 2 Anti-sigma-K factor rskA Shisa PF13908.6 CDI75686.1 - 0.0016 18.7 5.3 0.0016 18.7 5.3 5.6 3 2 1 4 4 4 1 Wnt and FGF inhibitory regulator SR-25 PF10500.9 CDI75686.1 - 0.0066 16.1 7.9 0.0066 16.1 7.9 4.2 3 2 0 3 3 3 1 Nuclear RNA-splicing-associated protein Zip PF02535.22 CDI75686.1 - 3.6 6.7 19.9 0.21 10.7 2.1 3.4 3 0 0 3 3 3 0 ZIP Zinc transporter Peptidase_S49_N PF08496.10 CDI75686.1 - 7.1 6.7 20.9 0.33 11.0 2.6 3.5 3 0 0 3 3 3 0 Peptidase family S49 N-terminal Spt20 PF12090.8 CDI75688.1 - 0.00077 19.1 14.0 0.00077 19.1 14.0 1.9 2 0 0 2 2 2 1 Spt20 family DUF2681 PF10883.8 CDI75688.1 - 0.0039 17.6 8.8 0.0039 17.6 8.8 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2681) DUF755 PF05501.11 CDI75688.1 - 0.0056 17.0 20.6 0.0056 17.0 20.6 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF755) TFIIA PF03153.13 CDI75688.1 - 0.054 13.5 42.1 0.066 13.2 42.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CHD5 PF04420.14 CDI75688.1 - 0.093 12.6 5.3 0.18 11.6 5.3 1.5 1 0 0 1 1 1 0 CHD5-like protein GREB1 PF15782.5 CDI75688.1 - 0.57 7.2 25.5 0.68 7.0 25.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF1980 PF09323.10 CDI75688.1 - 0.6 10.0 2.6 1.1 9.2 2.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) IMCp PF12314.8 CDI75689.1 - 1.4e-27 95.8 57.2 6.4e-26 90.5 39.6 2.8 2 1 1 3 3 3 2 Inner membrane complex protein IMCp PF12314.8 CDI75690.1 - 1.3e-16 60.7 51.6 8e-13 48.5 27.0 2.1 1 1 1 2 2 2 2 Inner membrane complex protein PI3K_1B_p101 PF10486.9 CDI75691.1 - 1.6 6.4 13.0 1.9 6.2 13.0 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SR-25 PF10500.9 CDI75692.1 - 0.00057 19.6 8.6 0.00057 19.6 8.6 3.6 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein Raftlin PF15250.6 CDI75692.1 - 0.98 8.1 29.2 0.016 14.0 16.7 2.0 2 0 0 2 2 2 0 Raftlin CCSAP PF15748.5 CDI75692.1 - 1.1 9.3 38.5 0.77 9.9 25.8 2.3 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated LMBR1 PF04791.16 CDI75692.1 - 1.7 7.4 11.4 3 6.6 11.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Cwf_Cwc_15 PF04889.12 CDI75692.1 - 3.7 7.2 34.4 4.4 7.0 3.7 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Pol_alpha_B_N PF08418.10 CDI75692.1 - 8.7 6.2 32.1 4 7.3 4.8 2.2 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal SLC12 PF03522.15 CDI75692.1 - 9.4 5.1 31.9 2.8 6.8 22.5 2.1 2 0 0 2 2 2 0 Solute carrier family 12 LcrR PF09621.10 CDI75693.1 - 0.017 14.5 0.0 0.04 13.4 0.0 1.6 1 0 0 1 1 1 0 Type III secretion system regulator (LcrR) Utp14 PF04615.13 CDI75694.1 - 0.068 11.7 16.9 0.089 11.4 16.9 1.1 1 0 0 1 1 1 0 Utp14 protein Arfaptin PF06456.13 CDI75694.1 - 0.14 11.7 2.6 2.5 7.6 1.9 2.1 1 1 1 2 2 2 0 Arfaptin-like domain SARAF PF06682.12 CDI75694.1 - 7.9 6.0 16.9 0.067 12.8 7.8 1.9 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Med3 PF11593.8 CDI75695.1 - 3.3 6.8 19.1 3.2 6.8 19.1 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF3984 PF13136.6 CDI75695.1 - 3.3 7.0 26.3 3.9 6.8 26.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) Spt20 PF12090.8 CDI75695.1 - 8.4 5.9 19.1 9.5 5.8 19.1 1.2 1 0 0 1 1 1 0 Spt20 family Ndc1_Nup PF09531.10 CDI75696.1 - 0.25 10.0 0.0 0.25 10.0 0.0 4.2 1 1 0 3 3 3 0 Nucleoporin protein Ndc1-Nup XRN_N PF03159.18 CDI75696.1 - 3.5 7.0 7.5 6.1 6.2 4.3 2.5 2 0 0 2 2 2 0 XRN 5'-3' exonuclease N-terminus Glyco_hydro_1 PF00232.18 CDI75696.1 - 4 5.7 7.6 0.54 8.6 2.1 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 1 DUF1980 PF09323.10 CDI75696.1 - 4.8 7.0 25.0 0.41 10.6 9.9 4.6 4 1 0 4 4 4 0 Domain of unknown function (DUF1980) TctB PF07331.11 CDI75697.1 - 0.00027 21.2 1.4 0.8 10.0 0.0 2.8 3 0 0 3 3 3 2 Tripartite tricarboxylate transporter TctB family DUF4834 PF16118.5 CDI75697.1 - 0.00069 20.5 2.6 0.00069 20.5 2.6 6.4 3 1 0 3 3 2 1 Domain of unknown function (DUF4834) Conotoxin PF02950.17 CDI75697.1 - 0.0036 18.3 3.5 0.0036 18.3 3.5 7.0 4 1 1 5 5 3 1 Conotoxin Spt20 PF12090.8 CDI75697.1 - 0.0064 16.1 3.4 0.0064 16.1 3.4 6.0 4 2 0 4 4 2 2 Spt20 family GRP PF07172.11 CDI75697.1 - 0.021 15.5 0.7 0.021 15.5 0.7 5.6 4 1 0 4 4 3 0 Glycine rich protein family EphA2_TM PF14575.6 CDI75697.1 - 0.024 15.5 0.4 0.024 15.5 0.4 6.4 4 1 0 4 4 3 0 Ephrin type-A receptor 2 transmembrane domain SAPS PF04499.15 CDI75697.1 - 0.11 11.3 40.9 1.8e+04 -8.2 41.1 3.0 1 1 0 1 1 0 0 SIT4 phosphatase-associated protein Peptidase_M50 PF02163.22 CDI75697.1 - 0.15 11.3 0.7 1.2 8.4 0.7 2.4 1 1 0 1 1 1 0 Peptidase family M50 Oxidored_q3 PF00499.20 CDI75697.1 - 0.24 11.1 3.8 1 9.0 0.4 2.9 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 MFS_1_like PF12832.7 CDI75697.1 - 0.28 10.0 0.7 1.5 7.5 0.1 2.2 1 1 1 2 2 2 0 MFS_1 like family Utp14 PF04615.13 CDI75697.1 - 0.43 9.1 64.0 0.19 10.3 54.9 2.1 1 1 1 2 2 2 0 Utp14 protein RAP1 PF07218.11 CDI75697.1 - 1.2 7.3 17.7 1.8 6.7 17.7 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Hamartin PF04388.12 CDI75697.1 - 4.5 5.8 69.1 0.1 11.3 54.9 2.0 2 0 0 2 2 2 0 Hamartin protein DUF2306 PF10067.9 CDI75699.1 - 2.3 8.4 6.6 0.25 11.6 0.2 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2306) Raftlin PF15250.6 CDI75700.1 - 0.26 10.0 33.2 0.38 9.4 33.2 1.3 1 0 0 1 1 1 0 Raftlin YcaO PF02624.16 CDI75700.1 - 0.54 9.5 7.1 0.65 9.2 7.1 1.2 1 0 0 1 1 1 0 YcaO cyclodehydratase, ATP-ad Mg2+-binding HCO3_cotransp PF00955.21 CDI75700.1 - 1.4 7.6 13.6 1.9 7.2 13.6 1.3 1 0 0 1 1 1 0 HCO3- transporter family Neur_chan_memb PF02932.16 CDI75700.1 - 1.9 8.5 28.8 3.3 7.7 28.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SID-1_RNA_chan PF13965.6 CDI75700.1 - 7.6 4.8 19.5 8.7 4.6 19.5 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CAC1F_C PF16885.5 CDI75700.1 - 8.3 6.0 30.8 8.9 5.9 30.8 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term DUF4045 PF13254.6 CDI75700.1 - 8.6 5.9 43.5 9.7 5.7 43.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PAT1 PF09770.9 CDI75700.1 - 9.8 4.3 54.2 12 4.1 54.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2722 PF10846.8 CDI75701.1 - 1.9e-05 23.8 2.2 1.9e-05 23.8 2.2 5.1 3 1 1 4 4 4 1 Protein of unknown function (DUF2722) Macoilin PF09726.9 CDI75701.1 - 0.0017 17.0 33.5 0.0017 17.0 33.5 3.0 3 0 0 3 3 3 2 Macoilin family SR-25 PF10500.9 CDI75701.1 - 0.0054 16.4 26.0 0.0054 16.4 26.0 4.0 3 1 1 4 4 4 2 Nuclear RNA-splicing-associated protein Peptidase_S49_N PF08496.10 CDI75701.1 - 0.016 15.3 0.9 0.016 15.3 0.9 4.9 4 1 1 5 5 5 0 Peptidase family S49 N-terminal Thg1C PF14413.6 CDI75701.1 - 0.59 10.3 42.0 0.75 10.0 0.4 4.9 5 0 0 5 5 5 0 Thg1 C terminal domain SARAF PF06682.12 CDI75701.1 - 2.7 7.5 0.0 2.7 7.5 0.0 4.6 2 2 1 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis Utp14 PF04615.13 CDI75701.1 - 3.4 6.1 50.6 0.53 8.8 43.9 2.2 2 0 0 2 2 2 0 Utp14 protein RskA PF10099.9 CDI75702.1 - 0.0007 19.9 1.5 0.0007 19.9 1.5 3.2 1 1 2 3 3 1 1 Anti-sigma-K factor rskA CDC27 PF09507.10 CDI75702.1 - 0.1 12.0 30.7 0.13 11.6 30.7 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RAP1 PF07218.11 CDI75702.1 - 0.15 10.3 0.4 0.22 9.8 0.4 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PAT1 PF09770.9 CDI75702.1 - 0.2 9.9 48.2 0.23 9.7 48.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDC45 PF02724.14 CDI75702.1 - 1.4 7.2 26.4 2.1 6.6 26.4 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4776 PF16003.5 CDI75702.1 - 1.8 7.4 24.8 2 7.3 24.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Peptidase_S46 PF10459.9 CDI75702.1 - 5.7 5.5 24.8 7.5 5.1 24.8 1.1 1 0 0 1 1 1 0 Peptidase S46 Hid1 PF12722.7 CDI75702.1 - 6.8 4.7 28.7 8.1 4.4 28.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CDI75702.1 - 6.9 3.6 27.8 7.4 3.5 27.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Caldesmon PF02029.15 CDI75702.1 - 7.9 5.1 38.1 10 4.8 38.1 1.1 1 0 0 1 1 1 0 Caldesmon SMYLE_N PF18615.1 CDI75702.1 - 9.4 5.7 25.6 14 5.1 25.6 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain IMUP PF15761.5 CDI75703.1 - 0.007 17.1 6.5 0.007 17.1 6.5 2.0 2 0 0 2 2 2 1 Immortalisation up-regulated protein CCDC106 PF15794.5 CDI75703.1 - 0.4 10.4 11.9 0.024 14.4 2.0 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 FliD_N PF02465.18 CDI75703.1 - 0.45 11.2 13.5 1.2 9.9 0.6 2.4 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Pap_E4 PF02711.14 CDI75703.1 - 2.5 9.1 11.5 16 6.5 4.2 2.6 2 0 0 2 2 2 0 E4 protein DUF3446 PF11928.8 CDI75703.1 - 8.7 6.7 17.3 0.35 11.2 11.5 1.7 2 0 0 2 2 2 0 Early growth response N-terminal domain Kelch_1 PF01344.25 CDI75704.1 - 1.1e-17 63.3 0.5 3.1e-09 36.3 0.1 2.9 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 CDI75704.1 - 1.7e-17 63.0 0.1 4.2e-11 42.7 0.1 2.1 1 1 1 2 2 2 2 Kelch motif Kelch_4 PF13418.6 CDI75704.1 - 1.8e-13 50.3 0.1 7.8e-10 38.6 0.1 2.6 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 CDI75704.1 - 1.1e-11 44.7 0.1 6.1e-06 26.4 0.2 2.1 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 CDI75704.1 - 2.3e-08 33.7 0.1 0.0018 18.1 0.1 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 CDI75704.1 - 4.1e-06 26.6 0.2 0.00025 21.0 0.0 2.8 3 0 0 3 3 3 1 Kelch motif DUF1668 PF07893.13 CDI75704.1 - 0.051 12.9 0.0 0.051 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1668) CN_hydrolase PF00795.22 CDI75705.1 - 8.6e-10 38.4 12.1 6.2e-05 22.5 0.6 2.8 2 1 0 2 2 2 2 Carbon-nitrogen hydrolase Tmemb_18A PF09771.9 CDI75705.1 - 0.083 13.3 0.1 21 5.5 0.0 2.5 2 1 0 2 2 2 0 Transmembrane protein 188 Otopetrin PF03189.13 CDI75706.1 - 0.085 11.7 0.0 0.085 11.7 0.0 4.9 3 2 1 4 4 4 0 Otopetrin DUF3040 PF11239.8 CDI75706.1 - 3.9 7.8 12.5 0.72 10.2 4.3 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) Activator_LAG-3 PF11498.8 CDI75707.1 - 0.004 16.2 6.0 0.004 16.2 6.0 6.9 6 2 1 7 7 7 3 Transcriptional activator LAG-3 DUF2722 PF10846.8 CDI75708.1 - 1.2e-05 24.5 5.3 1.2e-05 24.5 5.3 5.9 5 1 1 6 6 6 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI75708.1 - 0.00086 19.0 14.2 0.00086 19.0 14.2 6.5 5 1 0 6 6 6 2 Spt20 family V_ATPase_I PF01496.19 CDI75708.1 - 0.074 11.0 20.1 0.63 7.9 11.3 2.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Serinc PF03348.15 CDI75708.1 - 3.2 6.6 18.6 4.2 6.2 8.2 3.0 2 0 0 2 2 2 0 Serine incorporator (Serinc) SARAF PF06682.12 CDI75708.1 - 5 6.7 36.6 2.2 7.9 18.1 3.6 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis AP3D1 PF06375.11 CDI75708.1 - 9.3 6.5 22.4 2.4 8.4 0.7 3.1 3 0 0 3 3 3 0 AP-3 complex subunit delta-1 MAGE PF01454.19 CDI75709.1 - 0.16 11.7 6.3 0.21 11.3 6.3 1.2 1 0 0 1 1 1 0 MAGE family FCP1_C PF09309.10 CDI75709.1 - 0.25 11.2 10.4 0.32 10.8 10.4 1.1 1 0 0 1 1 1 0 FCP1, C-terminal ALMT PF11744.8 CDI75709.1 - 4.4 6.0 12.9 5.2 5.8 12.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter MDFI PF15316.6 CDI75709.1 - 5 7.2 12.5 6.2 6.9 12.5 1.2 1 0 0 1 1 1 0 MyoD family inhibitor TFIIA PF03153.13 CDI75709.1 - 5.3 6.9 17.4 7.5 6.4 17.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Menin PF05053.13 CDI75709.1 - 5.7 5.2 15.2 7.7 4.7 15.2 1.2 1 0 0 1 1 1 0 Menin UPF0565 PF10561.9 CDI75709.1 - 7.4 5.7 9.9 8.3 5.5 9.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Ribosomal_60s PF00428.19 CDI75710.1 - 2.1 9.0 17.3 0.74 10.4 6.7 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein LMBR1 PF04791.16 CDI75710.1 - 3.3 6.5 9.3 4.5 6.1 9.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4770 PF15994.5 CDI75710.1 - 4.9 7.4 27.9 4.9 7.4 7.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) DUF2072 PF09845.9 CDI75710.1 - 5.6 7.2 12.4 17 5.7 0.3 2.3 2 0 0 2 2 2 0 Zn-ribbon containing protein Pinin_SDK_memA PF04696.13 CDI75710.1 - 7.5 6.6 43.3 1 9.4 23.4 2.1 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region eIF-3_zeta PF05091.12 CDI75710.1 - 7.8 5.3 21.8 0.55 9.2 2.8 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AUX_IAA PF02309.16 CDI75710.1 - 8.1 6.2 13.5 18 5.1 8.0 2.1 2 0 0 2 2 2 0 AUX/IAA family DUF4746 PF15928.5 CDI75710.1 - 8.7 5.7 20.1 1.5 8.2 9.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF3626 PF12294.8 CDI75712.1 - 2.2e-05 23.7 0.8 0.0026 16.9 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3626) Pkinase PF00069.25 CDI75713.1 - 3e-25 89.1 0.0 3.6e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI75713.1 - 2.2e-16 59.9 0.0 2.7e-16 59.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI75713.1 - 3.4e-08 32.7 0.0 4.5e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase UME PF08064.13 CDI75717.1 - 0.13 12.1 0.1 1.9 8.4 0.1 2.9 2 0 0 2 2 2 0 UME (NUC010) domain DUF948 PF06103.11 CDI75717.1 - 0.26 11.6 6.2 1.5 9.1 0.3 4.1 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Lant_dehydr_C PF14028.6 CDI75717.1 - 0.31 10.6 4.7 0.31 10.5 1.3 2.8 2 1 0 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term DUF1664 PF07889.12 CDI75717.1 - 0.59 10.2 7.0 0.3 11.1 1.7 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) ApoLp-III PF07464.11 CDI75717.1 - 0.92 9.6 14.8 0.91 9.6 0.1 3.5 2 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) FlaC_arch PF05377.11 CDI75717.1 - 3.4 8.1 8.1 6.9 7.1 2.2 3.5 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) GST_C_3 PF14497.6 CDI75718.1 - 0.032 14.4 0.1 0.3 11.3 0.1 2.4 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain AP2 PF00847.20 CDI75719.1 - 3.4 8.0 7.5 0.17 12.1 1.5 2.0 2 0 0 2 2 2 0 AP2 domain SRP-alpha_N PF04086.13 CDI75721.1 - 0.39 10.6 22.0 0.06 13.3 17.5 1.9 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Tnp_22_trimer PF17489.2 CDI75723.1 - 0.088 12.8 0.5 0.3 11.1 0.1 2.1 2 0 0 2 2 2 0 L1 transposable element trimerization domain MCU PF04678.13 CDI75723.1 - 7 6.7 5.4 44 4.1 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial calcium uniporter DUF724 PF05266.14 CDI75724.1 - 0.011 15.6 10.1 0.011 15.6 10.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF724) IQ PF00612.27 CDI75724.1 - 0.016 14.9 0.2 0.051 13.4 0.2 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif PI_PP_I PF18363.1 CDI75724.1 - 0.58 10.4 7.5 0.13 12.4 2.0 2.6 2 1 1 3 3 3 0 Phosphoinositide phosphatase insertion domain Hydantoinase_B PF02538.14 CDI75724.1 - 0.76 8.1 7.5 0.83 8.0 6.8 1.4 1 1 0 1 1 1 0 Hydantoinase B/oxoprolinase Dpy-30 PF05186.13 CDI75725.1 - 7.7e-08 31.9 0.0 1.7e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Dpy-30 motif PocR PF10114.9 CDI75725.1 - 0.43 10.3 0.0 0.43 10.3 0.0 1.9 2 0 0 2 2 2 0 Sensory domain found in PocR MCM2_N PF12619.8 CDI75725.1 - 0.99 9.7 14.5 0.11 12.8 5.4 2.6 2 0 0 2 2 2 0 Mini-chromosome maintenance protein 2 DUF4407 PF14362.6 CDI75725.1 - 2.2 7.5 11.0 5 6.4 11.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Trypsin_2 PF13365.6 CDI75727.1 - 4.1e-17 63.5 0.1 8.2e-17 62.5 0.1 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain PDZ_6 PF17820.1 CDI75727.1 - 7.1e-06 25.8 0.0 1.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDI75727.1 - 3.5e-05 24.1 0.0 7.3e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDI75727.1 - 0.00069 19.9 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Peptidase_S7 PF00949.21 CDI75727.1 - 0.043 13.6 0.0 0.074 12.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S29 PF02907.15 CDI75727.1 - 0.072 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Trypsin PF00089.26 CDI75727.1 - 0.089 12.6 0.0 0.41 10.4 0.0 2.0 1 1 0 1 1 1 0 Trypsin EF-hand_8 PF13833.6 CDI75728.1 - 0.02 14.7 0.0 1.9 8.4 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain pair RVT_3 PF13456.6 CDI75728.1 - 0.044 13.6 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Reverse transcriptase-like Synuclein PF01387.17 CDI75728.1 - 0.076 13.2 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Synuclein Lamprin PF06403.11 CDI75729.1 - 0.059 13.3 0.7 0.089 12.7 0.7 1.3 1 0 0 1 1 1 0 Lamprin Ribosomal_S3Ae PF01015.18 CDI75730.1 - 2.3e-90 301.6 0.2 2.8e-90 301.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 CDI75730.1 - 0.19 11.3 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Kelch_3 PF13415.6 CDI75731.1 - 3e-17 62.5 1.9 5.1e-07 29.8 0.1 5.1 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI75731.1 - 1.4e-16 60.1 0.7 0.0035 17.3 0.0 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 CDI75731.1 - 3.2e-14 52.6 5.1 9.4e-06 25.6 0.0 5.6 4 1 1 5 5 5 3 Galactose oxidase, central domain HATPase_c_3 PF13589.6 CDI75731.1 - 1.5e-09 37.8 0.0 2.8e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Kelch_1 PF01344.25 CDI75731.1 - 6.4e-05 22.5 0.3 1.9 8.2 0.0 3.9 4 0 0 4 4 4 2 Kelch motif HATPase_c PF02518.26 CDI75731.1 - 0.00012 22.6 0.0 0.00027 21.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Kelch_6 PF13964.6 CDI75731.1 - 0.0015 18.8 3.1 0.09 13.1 0.1 4.1 2 2 3 5 5 5 1 Kelch motif PDCD2_C PF04194.13 CDI75732.1 - 7.3e-37 127.1 0.0 7.3e-37 127.1 0.0 2.5 3 0 0 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain zinc_ribbon_2 PF13240.6 CDI75732.1 - 0.0027 17.3 1.4 4.2 7.2 0.2 3.5 2 0 0 2 2 2 2 zinc-ribbon domain zf-RRN7 PF11781.8 CDI75732.1 - 0.011 15.4 0.5 1.2 8.9 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Lar_restr_allev PF14354.6 CDI75732.1 - 0.045 14.1 0.2 0.045 14.1 0.2 2.8 2 1 0 2 2 2 0 Restriction alleviation protein Lar Type_ISP_C PF18135.1 CDI75732.1 - 0.16 10.9 0.0 0.23 10.4 0.0 1.1 1 0 0 1 1 1 0 Type ISP C-terminal specificity domain Zn_Tnp_IS1595 PF12760.7 CDI75732.1 - 0.65 10.0 0.1 0.65 10.0 0.1 2.9 2 1 0 2 2 2 0 Transposase zinc-ribbon domain DARPP-32 PF05395.12 CDI75732.1 - 2.5 8.3 7.2 3.3 7.9 0.2 2.2 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 vATP-synt_E PF01991.18 CDI75733.1 - 3.5e-58 196.3 2.9 4.3e-58 196.0 2.9 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF4239 PF14023.6 CDI75733.1 - 0.0091 15.7 5.1 0.062 13.0 4.9 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4239) IL13 PF03487.13 CDI75733.1 - 0.089 12.6 1.7 0.11 12.2 0.4 1.8 2 0 0 2 2 2 0 Interleukin-13 Helicase_PWI PF18149.1 CDI75733.1 - 0.16 12.2 6.4 0.047 13.9 3.0 1.9 2 0 0 2 2 2 0 N-terminal helicase PWI domain CemA PF03040.14 CDI75733.1 - 0.37 10.7 5.4 0.53 10.2 5.4 1.3 1 0 0 1 1 1 0 CemA family Dynein_light PF01221.18 CDI75733.1 - 2.3 8.6 5.4 4.1 7.8 3.5 2.2 2 0 0 2 2 2 0 Dynein light chain type 1 CutA1 PF03091.15 CDI75734.1 - 1.6e-15 56.7 0.1 2.1e-15 56.4 0.1 1.1 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein Lipase_3 PF01764.25 CDI75735.1 - 9.7e-17 61.2 0.0 1.5e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 CDI75735.1 - 0.00089 18.6 0.0 0.0021 17.4 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDI75735.1 - 0.0028 18.3 0.5 0.0028 18.3 0.5 2.7 2 1 1 3 3 3 1 Alpha/beta hydrolase family Cutinase PF01083.22 CDI75735.1 - 0.059 13.3 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Cutinase Abhydrolase_1 PF00561.20 CDI75735.1 - 0.083 12.5 0.1 0.31 10.6 0.0 2.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold MA3 PF02847.17 CDI75737.1 - 1.1e-29 102.7 1.7 1.2e-09 38.1 0.0 3.2 3 0 0 3 3 3 3 MA3 domain PARP PF00644.20 CDI75738.1 - 3.1e-10 40.0 0.0 2.9e-05 23.8 0.1 2.6 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain RtxA PF07634.11 CDI75738.1 - 0.17 12.5 0.2 4.8 7.9 0.1 2.9 2 0 0 2 2 2 0 RtxA repeat Pex16 PF08610.10 CDI75739.1 - 3.6e-31 108.5 0.9 7.9e-31 107.4 0.9 1.5 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Sec7 PF01369.20 CDI75740.1 - 3.3e-66 222.5 0.0 5e-66 221.9 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 CDI75740.1 - 3.1e-13 49.9 0.2 9.6e-13 48.3 0.2 1.9 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal SUIM_assoc PF16619.5 CDI75740.1 - 0.0064 16.5 1.3 0.0064 16.5 1.3 7.1 7 0 0 7 7 7 2 Unstructured region C-term to UIM in Ataxin3 DUF1179 PF06678.11 CDI75740.1 - 0.19 11.8 1.2 1.2 9.2 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) ASH PF15780.5 CDI75741.1 - 0.0012 19.0 3.3 14 5.9 0.0 6.1 7 0 0 7 7 7 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Piwi PF02171.17 CDI75742.1 - 7.5e-11 41.8 0.1 4.3e-06 26.2 0.0 2.9 2 1 0 2 2 2 2 Piwi domain PAZ PF02170.22 CDI75742.1 - 1.6e-09 37.7 0.0 9.2e-09 35.2 0.0 2.0 2 0 0 2 2 2 1 PAZ domain DUF4543 PF15076.6 CDI75742.1 - 0.085 13.0 0.2 8.1 6.7 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4543) DUF2428 PF10350.9 CDI75743.1 - 3.9e-17 62.4 3.9 3.9e-17 62.4 3.9 4.4 5 0 0 5 5 5 1 Putative death-receptor fusion protein (DUF2428) Biotin_lipoyl PF00364.22 CDI75746.1 - 3.7e-11 42.7 0.3 4.7e-11 42.4 0.3 1.2 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CDI75746.1 - 3.1e-08 33.3 0.0 3.4e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Biotin-lipoyl like HlyD_D23 PF16576.5 CDI75746.1 - 4.3e-06 26.1 0.0 4.8e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion PTS_EIIA_1 PF00358.20 CDI75746.1 - 0.015 15.0 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 HlyD_3 PF13437.6 CDI75746.1 - 0.059 14.1 0.0 0.085 13.6 0.0 1.2 1 0 0 1 1 1 0 HlyD family secretion protein Ras PF00071.22 CDI75748.1 - 9.2e-55 184.7 0.1 9.2e-55 184.7 0.1 2.5 2 1 0 2 2 1 1 Ras family Roc PF08477.13 CDI75748.1 - 1e-35 122.5 0.1 1e-35 122.5 0.1 3.2 2 1 1 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI75748.1 - 5.8e-14 51.9 0.1 5.8e-14 51.9 0.1 2.0 2 1 0 2 2 1 1 ADP-ribosylation factor family Caldesmon PF02029.15 CDI75748.1 - 3.9e-06 25.9 17.7 4.5e-06 25.7 17.7 1.1 1 0 0 1 1 1 1 Caldesmon MMR_HSR1 PF01926.23 CDI75748.1 - 0.00093 19.3 5.9 0.0047 17.0 0.0 2.6 3 0 0 3 3 3 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDI75748.1 - 0.0084 15.5 0.0 0.0084 15.5 0.0 2.2 2 0 0 2 2 1 1 Gtr1/RagA G protein conserved region V_ATPase_I PF01496.19 CDI75748.1 - 0.02 12.9 23.8 0.027 12.4 23.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4776 PF16003.5 CDI75748.1 - 0.052 12.5 33.0 0.076 12.0 33.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) GREB1 PF15782.5 CDI75748.1 - 0.073 10.2 36.2 0.091 9.9 36.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RAP1 PF07218.11 CDI75748.1 - 0.25 9.6 8.8 0.33 9.2 8.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Nha1_C PF08619.10 CDI75748.1 - 0.39 9.9 33.7 0.81 8.8 33.7 1.5 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Auxin_canalis PF05703.11 CDI75749.1 - 0.014 15.3 22.5 0.019 14.9 22.5 1.1 1 0 0 1 1 1 0 Auxin canalisation TFIIA PF03153.13 CDI75749.1 - 0.039 14.0 35.2 0.054 13.5 35.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM76 PF16046.5 CDI75749.1 - 0.047 13.1 14.7 0.054 12.8 14.7 1.1 1 0 0 1 1 1 0 FAM76 protein Draxin PF15550.6 CDI75749.1 - 0.073 12.9 12.6 0.085 12.7 12.6 1.0 1 0 0 1 1 1 0 Draxin OATP PF03137.20 CDI75749.1 - 0.13 10.5 3.5 0.15 10.3 3.5 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family FAM60A PF15396.6 CDI75749.1 - 0.16 12.0 8.2 0.17 11.9 8.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Endostatin PF06482.11 CDI75749.1 - 0.2 11.1 14.6 0.22 10.9 14.6 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin eIF-3_zeta PF05091.12 CDI75749.1 - 0.23 10.4 16.5 0.28 10.1 16.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4638 PF15472.6 CDI75749.1 - 0.31 10.7 8.0 0.33 10.7 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) NPR3 PF03666.13 CDI75749.1 - 0.32 9.7 11.6 0.35 9.6 11.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 CDI75749.1 - 0.47 9.2 16.6 0.52 9.0 16.6 1.2 1 0 0 1 1 1 0 Presenilin BAF1_ABF1 PF04684.13 CDI75749.1 - 0.68 8.9 21.4 0.89 8.5 21.4 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF3347 PF11827.8 CDI75749.1 - 0.71 10.0 20.5 0.82 9.8 20.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) PAT1 PF09770.9 CDI75749.1 - 0.72 8.0 31.1 0.82 7.9 31.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Sec62 PF03839.16 CDI75749.1 - 0.73 9.3 9.5 0.81 9.2 9.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 RR_TM4-6 PF06459.12 CDI75749.1 - 0.73 9.6 12.9 0.83 9.4 12.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MMR1 PF08505.10 CDI75749.1 - 0.79 10.0 19.5 0.98 9.7 19.5 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Lin-8 PF03353.15 CDI75749.1 - 0.98 8.9 16.8 1.4 8.4 16.8 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MDM10 PF12519.8 CDI75749.1 - 1 8.1 10.4 1.1 8.0 10.4 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Band_3_cyto PF07565.13 CDI75749.1 - 1.1 9.1 13.7 1.3 8.8 13.7 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Neur_chan_memb PF02932.16 CDI75749.1 - 1.4 9.0 14.4 1.5 8.8 14.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI75749.1 - 1.4 7.7 12.4 1.5 7.5 12.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PCNP PF15473.6 CDI75749.1 - 1.6 9.5 10.2 2.2 9.0 10.2 1.3 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family CLN3 PF02487.17 CDI75749.1 - 1.8 7.5 9.3 2 7.4 9.3 1.3 1 0 0 1 1 1 0 CLN3 protein Membralin PF09746.9 CDI75749.1 - 1.8 7.5 7.9 2 7.4 7.9 1.1 1 0 0 1 1 1 0 Tumour-associated protein CSG2 PF16965.5 CDI75749.1 - 1.9 7.3 4.5 2.2 7.2 4.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4746 PF15928.5 CDI75749.1 - 2.1 7.7 10.4 2.6 7.4 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SLC12 PF03522.15 CDI75749.1 - 2.4 7.1 16.3 2.5 7.0 16.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 HGTP_anticodon2 PF12745.7 CDI75749.1 - 3.1 7.2 16.8 4.1 6.8 16.8 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Afi1 PF07792.12 CDI75749.1 - 3.5 8.1 14.5 4.5 7.8 14.5 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Sin_N PF04801.13 CDI75749.1 - 3.6 6.7 24.0 4.5 6.4 24.0 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Cellulose_synt PF03552.14 CDI75749.1 - 3.8 5.9 4.5 4.2 5.7 4.5 1.0 1 0 0 1 1 1 0 Cellulose synthase TMEM51 PF15345.6 CDI75749.1 - 3.9 7.2 19.1 4.8 7.0 19.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Miga PF10265.9 CDI75749.1 - 4.3 6.2 13.5 4.8 6.0 13.5 1.0 1 0 0 1 1 1 0 Mitoguardin XRN_M PF17846.1 CDI75749.1 - 7 5.5 10.3 7.7 5.4 10.3 1.2 1 0 0 1 1 1 0 Xrn1 helical domain AF-4 PF05110.13 CDI75750.1 - 0.11 10.6 87.4 0.17 10.0 87.4 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TFIIA PF03153.13 CDI75751.1 - 0.024 14.6 48.7 0.034 14.1 48.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF572 PF04502.13 CDI75751.1 - 0.043 13.5 14.2 0.05 13.2 14.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF2126 PF09899.9 CDI75751.1 - 0.083 11.0 8.0 0.074 11.1 8.0 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CNDH2_N PF06278.11 CDI75751.1 - 0.15 12.2 0.3 0.15 12.2 0.3 2.4 1 1 0 2 2 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal V_ATPase_I PF01496.19 CDI75751.1 - 0.28 9.0 16.1 0.38 8.6 16.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI75751.1 - 0.39 9.7 7.9 0.58 9.1 7.9 1.3 1 0 0 1 1 1 0 CLN3 protein eIF-3_zeta PF05091.12 CDI75751.1 - 0.43 9.5 16.4 0.54 9.2 16.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rrn6 PF10214.9 CDI75751.1 - 0.8 8.1 21.0 0.97 7.8 21.0 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Zip PF02535.22 CDI75751.1 - 1 8.5 8.8 1.9 7.7 8.8 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Hid1 PF12722.7 CDI75751.1 - 1.1 7.3 13.4 1.6 6.8 13.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PAT1 PF09770.9 CDI75751.1 - 1.3 7.2 31.9 1.6 6.9 31.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FAM91_C PF14648.6 CDI75751.1 - 1.5 7.5 11.9 2.1 7.1 11.9 1.1 1 0 0 1 1 1 0 FAM91 C-terminus SLC12 PF03522.15 CDI75751.1 - 1.6 7.7 14.6 2 7.4 14.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CSG2 PF16965.5 CDI75751.1 - 2.8 6.8 5.3 3.4 6.5 5.3 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Folate_carrier PF01770.18 CDI75751.1 - 9.1 4.9 6.6 15 4.1 6.6 1.5 1 0 0 1 1 1 0 Reduced folate carrier DUF5542 PF17696.1 CDI75752.1 - 0.029 14.5 5.6 0.029 14.5 5.6 6.6 6 2 0 6 6 6 0 Family of unknown function (DUF5542) Methyltrn_RNA_4 PF09936.9 CDI75752.1 - 0.18 11.6 0.1 0.18 11.6 0.1 3.3 3 1 0 3 3 3 0 SAM-dependent RNA methyltransferase Pkinase PF00069.25 CDI75752.1 - 6.8 6.0 26.0 0.028 13.8 10.3 3.8 2 1 0 2 2 2 0 Protein kinase domain RskA PF10099.9 CDI75753.1 - 1.6e-08 35.0 1.3 0.0018 18.6 0.0 8.8 1 1 4 6 6 6 3 Anti-sigma-K factor rskA CIAPIN1 PF05093.13 CDI75754.1 - 0.011 16.3 9.3 0.012 16.1 9.3 1.2 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Pex14_N PF04695.13 CDI75754.1 - 0.014 16.1 20.6 0.017 15.8 20.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 CDI75754.1 - 0.023 14.3 39.6 0.027 14.1 39.6 1.2 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 CDI75754.1 - 0.025 13.5 31.0 0.031 13.2 31.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Connexin PF00029.19 CDI75754.1 - 0.035 13.8 6.6 0.034 13.9 6.6 1.1 1 0 0 1 1 1 0 Connexin FAM176 PF14851.6 CDI75754.1 - 0.048 13.3 5.1 0.052 13.2 5.1 1.1 1 0 0 1 1 1 0 FAM176 family SpoIIP PF07454.11 CDI75754.1 - 0.05 13.1 12.1 0.05 13.1 12.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) NPR3 PF03666.13 CDI75754.1 - 0.063 12.1 8.0 0.06 12.1 8.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BAF1_ABF1 PF04684.13 CDI75754.1 - 0.081 12.0 12.6 0.086 11.9 12.6 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Peroxin-13_N PF04088.13 CDI75754.1 - 0.093 13.0 5.5 0.11 12.7 5.5 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region CobT PF06213.12 CDI75754.1 - 0.13 11.7 20.0 0.14 11.6 20.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TMEM51 PF15345.6 CDI75754.1 - 0.16 11.8 11.9 0.16 11.8 11.9 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4820 PF16091.5 CDI75754.1 - 0.17 11.2 9.0 0.18 11.2 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) ABC2_membrane_2 PF12679.7 CDI75754.1 - 0.18 11.0 6.7 0.2 10.9 6.7 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein TERB2 PF15101.6 CDI75754.1 - 0.19 11.7 20.6 0.22 11.6 20.6 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 OATP PF03137.20 CDI75754.1 - 0.22 9.7 6.1 0.22 9.8 6.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family EIIBC-GUT_N PF03612.14 CDI75754.1 - 0.3 10.8 11.5 0.33 10.7 11.5 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus MPM1 PF17234.2 CDI75754.1 - 0.3 11.3 13.3 0.33 11.2 13.3 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 DUF2076 PF09849.9 CDI75754.1 - 0.31 11.1 32.4 0.38 10.7 32.4 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) PsbW PF07123.12 CDI75754.1 - 0.32 11.0 5.3 0.44 10.6 5.3 1.3 1 0 0 1 1 1 0 Photosystem II reaction centre W protein (PsbW) Eapp_C PF10238.9 CDI75754.1 - 0.33 11.0 16.0 0.35 10.9 16.0 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein Rxt3 PF08642.10 CDI75754.1 - 0.38 11.5 4.9 0.42 11.4 4.9 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 TFIIA PF03153.13 CDI75754.1 - 0.41 10.6 37.5 0.47 10.4 37.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ureide_permease PF07168.11 CDI75754.1 - 0.41 9.4 5.3 0.4 9.4 5.3 1.1 1 0 0 1 1 1 0 Ureide permease Apc15p PF05841.11 CDI75754.1 - 0.49 11.2 18.7 0.58 11.0 18.7 1.1 1 0 0 1 1 1 0 Apc15p protein DDHD PF02862.17 CDI75754.1 - 0.56 10.3 12.7 0.63 10.2 12.7 1.2 1 0 0 1 1 1 0 DDHD domain PTPRCAP PF15713.5 CDI75754.1 - 0.61 10.4 16.0 0.69 10.2 16.0 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CLN3 PF02487.17 CDI75754.1 - 0.64 9.0 9.2 0.67 8.9 9.2 1.1 1 0 0 1 1 1 0 CLN3 protein CDC45 PF02724.14 CDI75754.1 - 0.65 8.2 9.1 0.64 8.2 9.1 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM91_C PF14648.6 CDI75754.1 - 0.75 8.6 6.3 0.76 8.5 6.3 1.0 1 0 0 1 1 1 0 FAM91 C-terminus DUF4770 PF15994.5 CDI75754.1 - 0.81 9.9 15.4 0.87 9.8 15.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) FRQ PF09421.10 CDI75754.1 - 0.95 7.4 11.2 1.1 7.3 11.2 1.0 1 0 0 1 1 1 0 Frequency clock protein DUF913 PF06025.12 CDI75754.1 - 0.98 8.3 8.2 0.98 8.3 8.2 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RLL PF10036.9 CDI75754.1 - 1 9.1 18.5 1.2 8.9 18.5 1.0 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein Presenilin PF01080.17 CDI75754.1 - 1.1 8.0 17.5 1.1 7.9 17.5 1.0 1 0 0 1 1 1 0 Presenilin CPSF100_C PF13299.6 CDI75754.1 - 1.1 9.5 14.1 1.2 9.2 14.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal BORG_CEP PF14957.6 CDI75754.1 - 1.1 10.4 8.7 1.2 10.3 8.7 1.2 1 0 0 1 1 1 0 Cdc42 effector Band_3_cyto PF07565.13 CDI75754.1 - 1.1 9.0 12.4 1.2 8.9 12.4 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SID-1_RNA_chan PF13965.6 CDI75754.1 - 1.2 7.5 5.5 1.1 7.6 5.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Folate_carrier PF01770.18 CDI75754.1 - 1.2 7.8 7.4 1.2 7.8 7.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier Neur_chan_memb PF02932.16 CDI75754.1 - 1.3 9.1 12.8 1.3 9.0 12.8 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EPL1 PF10513.9 CDI75754.1 - 1.3 9.4 15.4 1.4 9.3 15.4 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF4199 PF13858.6 CDI75754.1 - 1.3 9.4 7.3 1.6 9.1 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) SLC12 PF03522.15 CDI75754.1 - 1.3 7.9 13.1 1.4 7.9 13.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 eIF-3_zeta PF05091.12 CDI75754.1 - 1.4 7.8 20.4 1.6 7.6 20.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PIP5K PF01504.18 CDI75754.1 - 1.5 8.0 11.3 1.5 8.0 11.3 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DNApol_Exo PF18136.1 CDI75754.1 - 1.5 7.9 10.6 1.5 7.9 10.6 1.1 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain Pkinase_fungal PF17667.1 CDI75754.1 - 1.5 7.5 7.3 1.6 7.5 7.3 1.0 1 0 0 1 1 1 0 Fungal protein kinase EOS1 PF12326.8 CDI75754.1 - 1.5 8.7 8.1 1.7 8.5 8.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein Tim54 PF11711.8 CDI75754.1 - 1.5 7.5 13.0 1.5 7.5 13.0 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF3408 PF11888.8 CDI75754.1 - 1.6 8.9 14.6 2 8.5 14.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) RNA_pol_Rbc25 PF08292.12 CDI75754.1 - 1.7 8.9 8.7 2.3 8.5 8.7 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 CSG2 PF16965.5 CDI75754.1 - 1.7 7.5 6.4 1.9 7.4 6.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator RED_N PF07808.13 CDI75754.1 - 1.8 8.1 16.6 1.9 8.0 16.6 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region NST1 PF13945.6 CDI75754.1 - 1.8 8.6 21.7 2.2 8.4 21.7 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator TFB6 PF17110.5 CDI75754.1 - 1.9 8.2 7.8 2.1 8.0 7.8 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH G0-G1_switch_2 PF15103.6 CDI75754.1 - 1.9 8.9 11.4 2.4 8.7 11.4 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 Gti1_Pac2 PF09729.9 CDI75754.1 - 1.9 8.5 12.5 2 8.4 12.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family MCU PF04678.13 CDI75754.1 - 2 8.5 10.3 2.2 8.3 10.3 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter MMR1 PF08505.10 CDI75754.1 - 2.1 8.6 18.3 2.2 8.5 18.3 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Cellulose_synt PF03552.14 CDI75754.1 - 2.1 6.7 5.0 1.9 6.9 5.0 1.0 1 0 0 1 1 1 0 Cellulose synthase ORC_WH_C PF18137.1 CDI75754.1 - 2.2 8.4 12.3 2.5 8.2 12.3 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal UPF0560 PF10577.9 CDI75754.1 - 2.3 6.6 24.7 2.7 6.4 24.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4746 PF15928.5 CDI75754.1 - 2.3 7.5 10.2 2.5 7.4 10.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Paf1 PF03985.13 CDI75754.1 - 2.3 7.1 17.4 2.7 6.9 17.4 1.0 1 0 0 1 1 1 0 Paf1 Peptidase_S49_N PF08496.10 CDI75754.1 - 2.4 8.2 11.4 2.7 8.0 11.4 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3292 PF11696.8 CDI75754.1 - 2.4 6.4 11.5 2.7 6.3 11.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) MMM1 PF10296.9 CDI75754.1 - 2.4 7.1 8.4 2.7 6.9 8.4 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 RR_TM4-6 PF06459.12 CDI75754.1 - 2.6 7.8 15.4 2.7 7.7 15.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 CDI75754.1 - 2.7 6.7 11.8 2.9 6.6 11.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Pannexin_like PF12534.8 CDI75754.1 - 2.7 7.0 10.1 2.8 6.9 10.1 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Sec62 PF03839.16 CDI75754.1 - 2.7 7.4 10.0 2.9 7.3 10.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 PPL5 PF18168.1 CDI75754.1 - 2.8 7.2 9.3 2.9 7.1 9.3 1.1 1 0 0 1 1 1 0 Prim-pol family 5 PAT1 PF09770.9 CDI75754.1 - 2.8 6.1 26.0 3.1 5.9 26.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 UPF0524 PF15823.5 CDI75754.1 - 2.9 7.2 9.9 3.3 7.1 9.9 1.1 1 0 0 1 1 1 0 UPF0524 of C3orf70 Suf PF05843.14 CDI75754.1 - 3.1 7.7 19.0 3.5 7.5 19.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MDM10 PF12519.8 CDI75754.1 - 3.1 6.6 11.4 3.2 6.5 11.4 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 MMU163 PF17119.5 CDI75754.1 - 3.3 6.8 8.4 3.7 6.6 8.4 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DUF4638 PF15472.6 CDI75754.1 - 3.3 7.4 12.1 3.3 7.4 12.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) BRF1 PF07741.13 CDI75754.1 - 3.5 8.0 15.6 4.2 7.8 15.6 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Serinc PF03348.15 CDI75754.1 - 3.7 6.4 7.7 4 6.3 7.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Membralin PF09746.9 CDI75754.1 - 3.9 6.4 7.6 4 6.4 7.6 1.0 1 0 0 1 1 1 0 Tumour-associated protein Ctr PF04145.15 CDI75754.1 - 3.9 8.1 8.3 4.3 7.9 8.3 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Orf78 PF06024.12 CDI75754.1 - 4 7.8 8.8 5.6 7.3 8.8 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Paramyxo_ncap PF00973.19 CDI75754.1 - 4.1 6.2 9.5 4.3 6.1 9.5 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein HCO3_cotransp PF00955.21 CDI75754.1 - 4.4 6.0 5.8 4.7 5.9 5.8 1.0 1 0 0 1 1 1 0 HCO3- transporter family DDRGK PF09756.9 CDI75754.1 - 4.5 6.8 19.5 5.3 6.6 19.5 1.0 1 0 0 1 1 1 0 DDRGK domain V_ATPase_I PF01496.19 CDI75754.1 - 4.6 5.0 15.4 5.2 4.9 15.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MecA PF05389.12 CDI75754.1 - 4.7 6.8 12.6 5.4 6.6 12.6 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) NEMP PF10225.9 CDI75754.1 - 4.8 6.8 6.8 5.3 6.6 6.8 1.2 1 0 0 1 1 1 0 NEMP family HemX PF04375.14 CDI75754.1 - 5 6.3 28.6 4.9 6.3 28.6 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2368 PF10166.9 CDI75754.1 - 5.2 6.7 16.0 6.4 6.4 16.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) GREB1 PF15782.5 CDI75754.1 - 5.3 4.0 17.7 5.9 3.9 17.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Renin_r PF07850.14 CDI75754.1 - 5.4 7.7 5.1 7.1 7.3 5.1 1.4 1 0 0 1 1 1 0 Renin receptor-like protein Kei1 PF08552.11 CDI75754.1 - 5.4 6.9 13.7 6.8 6.5 13.7 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Lin-8 PF03353.15 CDI75754.1 - 5.6 6.4 18.1 5.8 6.4 18.1 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2828 PF11443.8 CDI75754.1 - 5.6 4.9 15.4 6.3 4.8 15.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF3295 PF11702.8 CDI75754.1 - 6 6.1 17.5 6.5 6.0 17.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) PigN PF04987.14 CDI75754.1 - 6 5.6 6.6 5.8 5.7 6.6 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Otopetrin PF03189.13 CDI75754.1 - 6.3 5.5 9.0 6.7 5.4 9.0 1.1 1 0 0 1 1 1 0 Otopetrin XRN_N PF03159.18 CDI75754.1 - 6.4 6.1 10.8 6 6.2 10.8 1.0 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus Peptidase_S64 PF08192.11 CDI75754.1 - 7.1 5.0 13.1 7.5 4.9 13.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 PRC2_HTH_1 PF18118.1 CDI75754.1 - 7.2 7.5 12.8 9.1 7.2 12.8 1.1 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain DUF3405 PF11885.8 CDI75754.1 - 7.3 5.1 13.1 8 4.9 13.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) DUF2126 PF09899.9 CDI75754.1 - 7.7 4.4 12.4 8.9 4.2 12.4 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) FliP PF00813.20 CDI75754.1 - 8 6.3 5.6 8.5 6.2 5.6 1.1 1 0 0 1 1 1 0 FliP family DUF775 PF05603.12 CDI75754.1 - 8.4 5.9 17.7 12 5.4 17.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF775) CNDH2_M PF16869.5 CDI75754.1 - 8.8 7.0 13.2 10 6.8 13.2 1.2 1 0 0 1 1 1 0 PF16858 DUF4647 PF15504.6 CDI75754.1 - 9.2 5.2 17.2 11 5.0 17.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) AUX_IAA PF02309.16 CDI75754.1 - 9.7 6.0 12.5 11 5.8 12.5 1.0 1 0 0 1 1 1 0 AUX/IAA family XRCC4 PF06632.12 CDI75754.1 - 10 4.9 16.1 12 4.6 16.1 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Eapp_C PF10238.9 CDI75755.1 - 0.0017 18.5 8.2 0.0017 18.5 8.2 2.3 2 0 0 2 2 2 1 E2F-associated phosphoprotein NST1 PF13945.6 CDI75755.1 - 0.09 12.9 39.6 0.34 11.0 18.5 2.1 2 0 0 2 2 2 0 Salt tolerance down-regulator Apc15p PF05841.11 CDI75755.1 - 0.15 12.8 33.9 0.083 13.7 15.7 2.4 2 0 0 2 2 2 0 Apc15p protein Connexin PF00029.19 CDI75755.1 - 0.29 10.8 22.0 0.13 12.0 7.9 2.1 2 0 0 2 2 2 0 Connexin PTPRCAP PF15713.5 CDI75755.1 - 0.32 11.3 30.2 1.2 9.4 15.2 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated MFAP1 PF06991.11 CDI75755.1 - 0.35 10.7 27.1 0.057 13.3 7.7 2.2 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing DUF5427 PF10310.9 CDI75755.1 - 0.6 9.0 31.5 0.77 8.6 31.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Utp14 PF04615.13 CDI75755.1 - 0.65 8.5 28.6 0.8 8.2 28.6 1.1 1 0 0 1 1 1 0 Utp14 protein DUF4834 PF16118.5 CDI75755.1 - 0.91 10.5 34.6 2.4 9.2 17.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PRC2_HTH_1 PF18118.1 CDI75755.1 - 1 10.2 22.0 1.6 9.6 8.6 2.2 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain EIIBC-GUT_N PF03612.14 CDI75755.1 - 1.1 8.9 26.2 0.29 10.9 10.1 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Hamartin PF04388.12 CDI75755.1 - 1.4 7.5 26.6 1.6 7.3 26.6 1.1 1 0 0 1 1 1 0 Hamartin protein XAP5 PF04921.14 CDI75755.1 - 2.3 8.0 24.3 0.38 10.6 9.0 2.1 2 0 0 2 2 2 0 XAP5, circadian clock regulator MPM1 PF17234.2 CDI75755.1 - 2.5 8.3 31.4 5.6 7.2 15.0 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 EIF4E-T PF10477.9 CDI75755.1 - 2.6 6.8 47.5 3.1 6.5 47.5 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E PEHE PF15275.6 CDI75755.1 - 2.6 8.7 28.1 0.65 10.6 6.3 2.1 2 0 0 2 2 2 0 PEHE domain Pinin_SDK_memA PF04696.13 CDI75755.1 - 2.6 8.1 46.8 4.6 7.3 14.4 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Nha1_C PF08619.10 CDI75755.1 - 3 6.9 27.5 4.3 6.5 27.5 1.2 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus TFB6 PF17110.5 CDI75755.1 - 3.4 7.4 17.5 0.9 9.3 6.5 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF3464 PF11947.8 CDI75755.1 - 3.6 7.3 32.1 0.74 9.5 12.6 2.4 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Stig1 PF04885.13 CDI75755.1 - 5.5 7.5 20.8 6.4 7.3 7.6 2.2 2 0 0 2 2 2 0 Stigma-specific protein, Stig1 DUF4746 PF15928.5 CDI75755.1 - 6.2 6.2 22.4 0.57 9.5 7.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) MRP-S31 PF15433.6 CDI75755.1 - 7 6.2 34.2 11 5.6 34.2 1.3 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 DUF2072 PF09845.9 CDI75755.1 - 9.3 6.5 20.2 2 8.7 8.1 2.2 2 0 0 2 2 2 0 Zn-ribbon containing protein DUF501 PF04417.12 CDI75759.1 - 0.21 11.4 1.8 0.96 9.3 0.1 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF501) FAM221 PF14753.6 CDI75761.1 - 8.9e-06 25.4 2.0 8.9e-06 25.4 2.0 1.5 1 1 0 1 1 1 1 Protein FAM221A/B Rtf2 PF04641.12 CDI75761.1 - 0.00023 20.6 12.8 0.00026 20.4 12.8 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger Cwf_Cwc_15 PF04889.12 CDI75761.1 - 0.037 13.8 20.3 0.049 13.4 20.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Myticin-prepro PF10690.9 CDI75761.1 - 0.24 11.7 2.4 0.57 10.5 2.4 1.8 1 1 0 1 1 1 0 Myticin pre-proprotein from the mussel FAM60A PF15396.6 CDI75761.1 - 0.3 11.0 16.8 0.4 10.7 16.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DDHD PF02862.17 CDI75761.1 - 0.69 10.0 14.6 0.91 9.6 14.6 1.4 1 0 0 1 1 1 0 DDHD domain DUF913 PF06025.12 CDI75761.1 - 1.2 8.1 11.6 1.4 7.8 11.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Auxin_canalis PF05703.11 CDI75761.1 - 1.5 8.6 8.1 1.8 8.4 8.1 1.2 1 0 0 1 1 1 0 Auxin canalisation SprA-related PF12118.8 CDI75761.1 - 2.2 7.3 33.5 2.8 7.0 33.5 1.2 1 0 0 1 1 1 0 SprA-related family SID-1_RNA_chan PF13965.6 CDI75761.1 - 4.2 5.7 7.3 4.6 5.5 7.3 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF778 PF05608.12 CDI75761.1 - 6.9 7.0 11.6 7.5 6.9 11.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF778) GREB1 PF15782.5 CDI75761.1 - 9.8 3.1 19.3 9.6 3.2 19.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RskA PF10099.9 CDI75762.1 - 0.00071 19.9 8.5 0.00071 19.9 8.5 4.4 1 1 3 4 4 4 1 Anti-sigma-K factor rskA Mucin PF01456.17 CDI75762.1 - 0.0043 17.0 11.0 0.0043 17.0 11.0 2.5 2 0 0 2 2 2 1 Mucin-like glycoprotein DUF2052 PF09747.9 CDI75762.1 - 0.91 9.6 42.6 2.1 8.4 15.3 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Pinin_SDK_memA PF04696.13 CDI75762.1 - 6 6.9 57.6 1.2 9.2 9.8 3.2 3 0 0 3 3 3 0 pinin/SDK/memA/ protein conserved region Photo_RC PF00124.19 CDI75763.1 - 0.047 12.9 0.0 0.047 12.9 0.0 2.2 2 0 0 2 2 2 0 Photosynthetic reaction centre protein DUF4207 PF13904.6 CDI75763.1 - 0.098 12.3 22.5 0.048 13.3 5.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) TAP42 PF04177.12 CDI75763.1 - 0.28 10.3 14.2 0.13 11.4 1.6 2.1 2 0 0 2 2 2 0 TAP42-like family Med15 PF09606.10 CDI75763.1 - 0.35 9.5 37.8 0.45 9.2 37.8 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Pex14_N PF04695.13 CDI75763.1 - 0.43 11.2 29.4 0.081 13.6 9.1 2.9 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM60A PF15396.6 CDI75763.1 - 1 9.3 6.2 1.8 8.5 6.2 1.4 1 0 0 1 1 1 0 Protein Family FAM60A PAT1 PF09770.9 CDI75763.1 - 1.5 7.0 23.7 2.1 6.5 23.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ribosomal_60s PF00428.19 CDI75763.1 - 2.3 8.9 49.5 0.29 11.8 12.1 4.3 4 0 0 4 4 4 0 60s Acidic ribosomal protein Activator_LAG-3 PF11498.8 CDI75763.1 - 3.5 6.5 52.2 0.34 9.8 15.1 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 DFF40 PF09230.10 CDI75763.1 - 6.1 6.4 10.1 0.23 11.1 1.5 2.1 2 0 0 2 2 2 0 DNA fragmentation factor 40 kDa Trypan_PARP PF05887.11 CDI75765.1 - 3.3 7.7 23.7 7.7 6.5 9.0 2.3 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF4603 PF15376.6 CDI75766.1 - 0.025 12.0 3.7 0.028 11.8 3.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) RR_TM4-6 PF06459.12 CDI75766.1 - 0.027 14.3 8.8 0.028 14.2 8.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 CDI75766.1 - 0.033 13.4 14.9 0.034 13.4 14.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4228 PF14009.6 CDI75766.1 - 0.041 14.3 5.0 0.053 13.9 5.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Macoilin PF09726.9 CDI75766.1 - 0.07 11.7 13.2 0.079 11.5 13.2 1.0 1 0 0 1 1 1 0 Macoilin family SYF2 PF08231.12 CDI75766.1 - 0.074 13.4 9.5 0.091 13.2 9.5 1.1 1 0 0 1 1 1 0 SYF2 splicing factor Presenilin PF01080.17 CDI75766.1 - 0.082 11.7 14.9 0.093 11.5 14.9 1.1 1 0 0 1 1 1 0 Presenilin BORG_CEP PF14957.6 CDI75766.1 - 0.1 13.8 7.8 0.12 13.6 7.8 1.1 1 0 0 1 1 1 0 Cdc42 effector OATP PF03137.20 CDI75766.1 - 0.1 10.9 3.6 0.1 10.9 3.6 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family eIF-3_zeta PF05091.12 CDI75766.1 - 0.11 11.5 12.1 0.11 11.5 12.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CLN3 PF02487.17 CDI75766.1 - 0.11 11.5 7.1 0.12 11.4 7.1 1.1 1 0 0 1 1 1 0 CLN3 protein DUF3984 PF13136.6 CDI75766.1 - 0.13 11.6 22.3 0.16 11.4 22.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) SLC12 PF03522.15 CDI75766.1 - 0.15 11.1 9.6 0.15 11.1 9.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Endostatin PF06482.11 CDI75766.1 - 0.19 11.1 18.2 0.21 11.0 18.2 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin ALMT PF11744.8 CDI75766.1 - 0.2 10.5 7.8 0.19 10.5 7.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter TFIIA PF03153.13 CDI75766.1 - 0.27 11.2 39.1 0.34 10.9 39.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Band_3_cyto PF07565.13 CDI75766.1 - 0.28 11.0 13.0 0.3 10.8 13.0 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF1387 PF07139.11 CDI75766.1 - 0.28 10.9 11.6 0.3 10.8 11.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Spc7_N PF15402.6 CDI75766.1 - 0.29 9.3 16.8 0.38 9.0 16.8 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 PAT1 PF09770.9 CDI75766.1 - 0.39 8.9 31.5 0.44 8.8 31.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Tim54 PF11711.8 CDI75766.1 - 0.41 9.4 13.3 0.46 9.2 13.3 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Neur_chan_memb PF02932.16 CDI75766.1 - 0.42 10.6 10.6 0.43 10.6 10.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Exonuc_VII_L PF02601.15 CDI75766.1 - 0.45 10.0 14.3 0.57 9.7 14.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Connexin PF00029.19 CDI75766.1 - 0.52 10.0 11.1 0.6 9.8 11.1 1.1 1 0 0 1 1 1 0 Connexin PAP2_3 PF14378.6 CDI75766.1 - 0.58 9.8 6.0 0.99 9.1 6.0 1.5 1 1 0 1 1 1 0 PAP2 superfamily CSG2 PF16965.5 CDI75766.1 - 0.59 9.0 2.6 0.58 9.0 2.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator TERB2 PF15101.6 CDI75766.1 - 0.6 10.1 17.1 0.65 10.0 17.1 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Hydin_ADK PF17213.3 CDI75766.1 - 0.62 10.3 12.7 0.77 10.0 12.7 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Sec62 PF03839.16 CDI75766.1 - 0.69 9.4 8.9 0.74 9.3 8.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 V_ATPase_I PF01496.19 CDI75766.1 - 0.69 7.8 17.0 0.76 7.6 17.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Serinc PF03348.15 CDI75766.1 - 0.71 8.7 4.4 0.75 8.7 4.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF3295 PF11702.8 CDI75766.1 - 0.75 9.1 14.4 0.88 8.8 14.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) FAM60A PF15396.6 CDI75766.1 - 0.81 9.6 8.5 0.88 9.5 8.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A EPL1 PF10513.9 CDI75766.1 - 0.95 9.8 15.5 1.3 9.4 15.5 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like AF-4 PF05110.13 CDI75766.1 - 1.1 7.3 23.6 1.3 7.1 23.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Gti1_Pac2 PF09729.9 CDI75766.1 - 1.3 9.1 11.7 1.6 8.8 11.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family FAM76 PF16046.5 CDI75766.1 - 1.4 8.2 17.3 1.7 7.9 17.3 1.1 1 0 0 1 1 1 0 FAM76 protein MMR1 PF08505.10 CDI75766.1 - 1.6 9.0 16.5 2.5 8.3 16.5 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein NST1 PF13945.6 CDI75766.1 - 1.6 8.8 18.8 2.9 8.0 18.8 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF1180 PF06679.12 CDI75766.1 - 1.9 8.9 14.1 2.4 8.6 13.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) AUX_IAA PF02309.16 CDI75766.1 - 2.3 8.0 8.0 2.5 7.9 8.0 1.1 1 0 0 1 1 1 0 AUX/IAA family DUF3450 PF11932.8 CDI75766.1 - 2.3 7.5 19.6 2.9 7.2 19.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4050 PF13259.6 CDI75766.1 - 2.6 8.4 12.9 3.2 8.0 12.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Med26_M PF15694.5 CDI75766.1 - 2.9 7.9 26.0 3.6 7.6 26.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 26 middle domain DUF4770 PF15994.5 CDI75766.1 - 3.7 7.7 18.7 4.8 7.4 18.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Ndc1_Nup PF09531.10 CDI75766.1 - 3.9 6.0 11.3 4.4 5.9 11.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup IHABP4_N PF16174.5 CDI75766.1 - 4 8.0 16.8 5.9 7.5 16.8 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Paramyxo_ncap PF00973.19 CDI75766.1 - 4.1 6.2 8.0 4.3 6.1 8.0 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein MgsA_C PF12002.8 CDI75766.1 - 4.4 7.2 13.0 5.5 6.9 13.0 1.2 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal LMBR1 PF04791.16 CDI75766.1 - 4.9 5.9 7.1 5.1 5.9 7.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Hid1 PF12722.7 CDI75766.1 - 5 5.1 15.5 5.8 4.9 15.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SPX PF03105.19 CDI75766.1 - 5.3 6.9 14.6 6.3 6.6 14.6 1.0 1 0 0 1 1 1 0 SPX domain FliP PF00813.20 CDI75766.1 - 5.3 6.9 6.7 5.9 6.7 6.7 1.1 1 0 0 1 1 1 0 FliP family DUF5427 PF10310.9 CDI75766.1 - 5.4 5.9 17.9 6.3 5.6 17.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Velvet PF11754.8 CDI75766.1 - 6.2 6.7 19.1 8 6.3 19.1 1.1 1 0 0 1 1 1 0 Velvet factor MDM10 PF12519.8 CDI75766.1 - 7.5 5.3 12.3 8.2 5.2 12.3 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 HemX PF04375.14 CDI75766.1 - 9.3 5.4 23.7 11 5.2 23.7 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4175 PF13779.6 CDI75766.1 - 9.9 3.9 27.5 11 3.8 27.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SUIM_assoc PF16619.5 CDI75767.1 - 1.4 9.0 32.7 0.098 12.7 7.4 3.8 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 SPT6_acidic PF14632.6 CDI75767.1 - 1.6 9.4 0.0 1.6 9.4 0.0 4.5 2 1 1 3 3 3 0 Acidic N-terminal SPT6 GAGA_bind PF06217.12 CDI75769.1 - 0.012 15.9 9.6 0.012 15.9 9.6 3.5 3 1 0 3 3 3 0 GAGA binding protein-like family FAM91_C PF14648.6 CDI75769.1 - 0.12 11.2 23.5 0.23 10.3 23.5 1.4 1 0 0 1 1 1 0 FAM91 C-terminus SOBP PF15279.6 CDI75769.1 - 4.7 7.7 35.8 1.7 9.2 14.8 3.2 3 0 0 3 3 3 0 Sine oculis-binding protein zf-C3HC4_4 PF15227.6 CDI75773.1 - 1.2e-06 28.6 10.8 6.2e-06 26.3 10.8 2.3 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Macoilin PF09726.9 CDI75773.1 - 0.00016 20.4 35.3 0.00023 19.9 35.3 1.2 1 0 0 1 1 1 1 Macoilin family zf-RING_UBOX PF13445.6 CDI75773.1 - 0.00046 20.1 14.0 0.0023 17.9 14.0 2.3 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CDI75773.1 - 0.0023 17.7 10.3 0.0061 16.4 10.3 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDI75773.1 - 0.038 14.3 15.8 0.097 13.0 15.8 1.7 1 1 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 CDI75773.1 - 0.058 13.2 12.5 0.24 11.3 12.5 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_14 PF17978.1 CDI75773.1 - 0.09 13.2 9.1 0.074 13.5 7.7 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain TFIIA PF03153.13 CDI75773.1 - 0.093 12.7 60.4 0.14 12.1 60.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Rit1_C PF17184.4 CDI75773.1 - 0.15 11.5 11.5 0.29 10.5 11.5 1.5 1 0 0 1 1 1 0 Rit1 N-terminal domain SPX PF03105.19 CDI75773.1 - 0.27 11.1 26.2 0.39 10.6 26.2 1.2 1 0 0 1 1 1 0 SPX domain UPF0242 PF06785.11 CDI75773.1 - 0.39 10.8 37.0 0.79 9.8 37.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus AA_synth PF06684.11 CDI75773.1 - 0.45 10.0 1.5 0.72 9.4 0.9 1.7 1 1 0 1 1 1 0 Amino acid synthesis Prok-RING_4 PF14447.6 CDI75773.1 - 0.55 10.1 10.3 2.5 8.1 10.3 2.1 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 CDI75773.1 - 0.9 9.9 14.1 5.4 7.4 14.1 2.4 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 CDI75773.1 - 1.5 8.7 11.9 5.1 7.0 11.9 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) AMP-binding_C_2 PF14535.6 CDI75773.1 - 3.8 7.9 9.8 46 4.4 9.8 2.2 1 1 0 1 1 1 0 AMP-binding enzyme C-terminal domain WW PF00397.26 CDI75774.1 - 2.9e-09 36.8 1.9 4.9e-09 36.1 1.9 1.4 1 0 0 1 1 1 1 WW domain YIF1 PF03878.15 CDI75774.1 - 4.3e-05 23.2 0.1 0.068 12.7 0.0 2.5 2 0 0 2 2 2 2 YIF1 Yip1 PF04893.17 CDI75774.1 - 0.00019 21.2 14.9 0.0059 16.3 14.8 3.1 2 1 1 3 3 3 1 Yip1 domain DUF898 PF05987.13 CDI75774.1 - 0.014 14.5 8.3 0.34 9.9 7.6 2.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF898) V_ATPase_I PF01496.19 CDI75774.1 - 0.87 7.4 9.0 0.95 7.3 7.2 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 CDI75774.1 - 3.8 6.2 15.5 0.45 9.2 8.6 2.6 3 0 0 3 3 3 0 Presenilin SLC12 PF03522.15 CDI75774.1 - 3.9 6.4 9.1 11 4.9 9.1 1.7 1 0 0 1 1 1 0 Solute carrier family 12 SR-25 PF10500.9 CDI75775.1 - 0.00061 19.5 12.0 0.00061 19.5 12.0 10.4 9 2 2 11 11 11 5 Nuclear RNA-splicing-associated protein SARAF PF06682.12 CDI75775.1 - 0.0012 18.6 0.0 0.0012 18.6 0.0 9.0 5 3 3 8 8 8 2 SOCE-associated regulatory factor of calcium homoeostasis DUF3169 PF11368.8 CDI75775.1 - 0.02 14.4 2.4 9.7 5.6 0.0 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF3169) DUF572 PF04502.13 CDI75776.1 - 0.17 11.5 27.7 0.24 11.0 27.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Bud13 PF09736.9 CDI75776.1 - 2.5 8.5 22.4 0.14 12.6 16.1 1.9 2 1 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex PPP4R2 PF09184.11 CDI75776.1 - 3.2 7.3 31.3 4 7.0 15.0 2.1 2 0 0 2 2 2 0 PPP4R2 Vfa1 PF08432.10 CDI75776.1 - 3.3 8.0 26.5 0.62 10.4 13.4 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 PTPlike_phytase PF14566.6 CDI75776.1 - 4.5 7.4 8.9 4.3 7.4 7.6 1.6 2 0 0 2 2 2 0 Inositol hexakisphosphate GTA_holin_3TM PF11351.8 CDI75776.1 - 5 7.7 11.4 13 6.4 11.4 1.7 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release FUSC PF04632.12 CDI75776.1 - 7.9 4.9 9.5 11 4.5 9.5 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family SUIM_assoc PF16619.5 CDI75777.1 - 0.0023 17.9 3.3 0.0023 17.9 3.3 9.2 4 2 3 7 7 7 2 Unstructured region C-term to UIM in Ataxin3 K_channel_TID PF07941.11 CDI75777.1 - 0.01 16.3 6.3 0.01 16.3 6.3 10.9 10 4 2 12 12 12 0 Potassium channel Kv1.4 tandem inactivation domain DUF4065 PF13274.6 CDI75777.1 - 9.8 7.1 7.1 56 4.7 3.8 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4065) SR-25 PF10500.9 CDI75778.1 - 0.0001 22.0 61.3 0.0028 17.3 4.5 3.2 2 1 0 3 3 3 3 Nuclear RNA-splicing-associated protein Zip PF02535.22 CDI75778.1 - 0.006 15.8 4.7 0.006 15.8 4.7 2.5 2 1 0 2 2 2 1 ZIP Zinc transporter SurA_N_2 PF13623.6 CDI75778.1 - 0.09 12.6 0.4 0.09 12.6 0.4 5.9 3 3 2 5 5 5 0 SurA N-terminal domain PRP38_assoc PF12871.7 CDI75779.1 - 0.35 11.5 132.0 6.6e+02 1.0 54.1 3.7 1 1 1 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DNA_topoisoIV PF00521.20 CDI75781.1 - 1.9e-21 76.5 1.2 2.8e-21 75.9 1.2 1.3 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A MAP65_ASE1 PF03999.12 CDI75782.1 - 0.018 13.8 9.8 0.078 11.7 9.9 1.8 1 1 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Presenilin PF01080.17 CDI75783.1 - 0.041 12.7 32.4 0.044 12.5 32.4 1.0 1 0 0 1 1 1 0 Presenilin PNISR PF15996.5 CDI75783.1 - 0.12 12.7 30.0 0.14 12.4 30.0 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR NPR3 PF03666.13 CDI75783.1 - 0.17 10.6 28.1 0.2 10.4 28.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CLN3 PF02487.17 CDI75783.1 - 1.6 7.7 20.9 2.4 7.1 20.9 1.2 1 0 0 1 1 1 0 CLN3 protein CDC45 PF02724.14 CDI75783.1 - 1.7 6.8 25.1 1.9 6.7 25.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Lin-8 PF03353.15 CDI75783.1 - 2.1 7.8 32.8 2.3 7.7 32.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist HCO3_cotransp PF00955.21 CDI75783.1 - 2.4 6.9 15.5 3 6.6 15.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family Zip PF02535.22 CDI75783.1 - 2.7 7.1 32.4 3.4 6.8 32.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3295 PF11702.8 CDI75783.1 - 3.2 7.0 24.7 3.7 6.8 24.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) BORG_CEP PF14957.6 CDI75783.1 - 3.9 8.7 20.2 5.5 8.2 20.2 1.3 1 0 0 1 1 1 0 Cdc42 effector SLC12 PF03522.15 CDI75783.1 - 5 6.0 33.3 5.7 5.9 33.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4045 PF13254.6 CDI75783.1 - 6.2 6.4 22.5 6.8 6.2 22.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CKAP2_C PF15297.6 CDI75783.1 - 7.3 5.6 19.3 8.3 5.4 19.3 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus MDFI PF15316.6 CDI75783.1 - 7.6 6.6 22.9 9.2 6.3 22.9 1.1 1 0 0 1 1 1 0 MyoD family inhibitor Hamartin PF04388.12 CDI75783.1 - 8.3 4.9 29.8 9 4.8 29.8 1.0 1 0 0 1 1 1 0 Hamartin protein Neur_chan_memb PF02932.16 CDI75783.1 - 8.3 6.4 26.4 11 6.0 26.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI75783.1 - 9.8 4.9 26.5 11 4.7 26.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Membralin PF09746.9 CDI75783.1 - 10 5.1 20.9 11 4.9 20.9 1.1 1 0 0 1 1 1 0 Tumour-associated protein Spt20 PF12090.8 CDI75784.1 - 0.00029 20.5 21.2 0.00029 20.5 21.2 1.1 1 0 0 1 1 1 1 Spt20 family Conotoxin PF02950.17 CDI75784.1 - 0.00032 21.6 2.6 0.00053 20.9 2.6 1.4 1 0 0 1 1 1 1 Conotoxin Activator_LAG-3 PF11498.8 CDI75784.1 - 0.0039 16.2 26.6 0.0039 16.2 26.6 1.1 1 0 0 1 1 1 1 Transcriptional activator LAG-3 FHIPEP PF00771.20 CDI75784.1 - 0.0042 15.6 4.4 0.0041 15.7 4.4 1.0 1 0 0 1 1 1 1 FHIPEP family RskA PF10099.9 CDI75784.1 - 0.0064 16.8 12.9 0.0076 16.6 12.9 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI75784.1 - 0.0085 15.1 5.2 0.008 15.2 5.2 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4834 PF16118.5 CDI75784.1 - 0.012 16.5 5.8 0.016 16.2 5.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Connexin PF00029.19 CDI75784.1 - 0.022 14.6 1.5 0.023 14.4 1.5 1.1 1 0 0 1 1 1 0 Connexin DUF2572 PF10833.8 CDI75784.1 - 0.027 14.3 8.3 0.031 14.0 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) CBP_BcsG PF11658.8 CDI75784.1 - 0.036 12.5 3.8 0.035 12.5 3.8 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG CLN3 PF02487.17 CDI75784.1 - 0.039 13.0 3.3 0.036 13.1 3.3 1.0 1 0 0 1 1 1 0 CLN3 protein V_ATPase_I PF01496.19 CDI75784.1 - 0.039 11.9 4.7 0.039 11.9 4.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4746 PF15928.5 CDI75784.1 - 0.041 13.3 5.0 0.04 13.4 5.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Presenilin PF01080.17 CDI75784.1 - 0.048 12.4 5.4 0.046 12.5 5.4 1.1 1 0 0 1 1 1 0 Presenilin Cons_hypoth698 PF03601.14 CDI75784.1 - 0.067 12.1 3.4 0.097 11.5 3.4 1.3 1 1 0 1 1 1 0 Conserved hypothetical protein 698 EIIBC-GUT_N PF03612.14 CDI75784.1 - 0.074 12.8 3.8 0.077 12.7 3.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus R_equi_Vir PF05526.11 CDI75784.1 - 0.076 12.9 3.1 0.086 12.7 3.1 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein eIF_4EBP PF05456.11 CDI75784.1 - 0.098 12.6 5.3 0.12 12.3 5.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) TCRP1 PF14944.6 CDI75784.1 - 0.1 12.5 2.5 0.12 12.3 2.5 1.0 1 0 0 1 1 1 0 Tongue Cancer Chemotherapy Resistant Protein 1 Suf PF05843.14 CDI75784.1 - 0.12 12.4 9.3 0.11 12.4 9.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 CDI75784.1 - 0.13 12.3 27.6 0.12 12.3 27.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI75784.1 - 0.13 12.4 5.3 0.13 12.4 5.3 1.1 1 0 0 1 1 1 0 DDHD domain Dpy19 PF10034.9 CDI75784.1 - 0.19 9.9 1.0 0.18 10.0 1.0 1.0 1 0 0 1 1 1 0 Q-cell neuroblast polarisation DUF3959 PF13105.6 CDI75784.1 - 0.21 11.1 2.7 0.24 10.9 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) SID-1_RNA_chan PF13965.6 CDI75784.1 - 0.25 9.7 1.0 0.23 9.9 1.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SpoIIP PF07454.11 CDI75784.1 - 0.33 10.4 7.8 0.39 10.1 7.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) OATP PF03137.20 CDI75784.1 - 0.33 9.2 2.3 0.32 9.2 2.3 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family ALMT PF11744.8 CDI75784.1 - 0.33 9.7 3.3 0.3 9.9 3.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Peptidase_S15 PF02129.18 CDI75784.1 - 0.35 10.4 5.3 0.4 10.2 5.3 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF1980 PF09323.10 CDI75784.1 - 0.35 10.8 3.0 0.37 10.7 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) FAM150 PF15129.6 CDI75784.1 - 0.37 11.0 6.6 0.45 10.7 6.6 1.1 1 0 0 1 1 1 0 FAM150 family Ureide_permease PF07168.11 CDI75784.1 - 0.4 9.4 1.4 0.38 9.5 1.4 1.1 1 0 0 1 1 1 0 Ureide permease Glt_symporter PF03616.14 CDI75784.1 - 0.42 9.2 1.6 0.46 9.1 1.6 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter Neur_chan_memb PF02932.16 CDI75784.1 - 0.45 10.5 3.4 0.44 10.6 3.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Serinc PF03348.15 CDI75784.1 - 0.49 9.3 2.8 0.47 9.3 2.8 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) NEMP PF10225.9 CDI75784.1 - 0.58 9.8 2.8 0.59 9.8 2.8 1.0 1 0 0 1 1 1 0 NEMP family UPF0524 PF15823.5 CDI75784.1 - 0.83 9.0 6.8 1.1 8.6 6.8 1.1 1 0 0 1 1 1 0 UPF0524 of C3orf70 TMEM208_SND2 PF05620.11 CDI75784.1 - 1.2 8.9 6.3 1.3 8.8 6.3 1.3 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 UPF0560 PF10577.9 CDI75784.1 - 1.4 7.4 13.7 1.4 7.3 13.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PigN PF04987.14 CDI75784.1 - 1.4 7.7 4.3 1.7 7.4 4.3 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Rpp20 PF12328.8 CDI75784.1 - 1.7 8.6 8.9 2.5 8.0 8.9 1.2 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P Herpes_DNAp_acc PF04929.12 CDI75784.1 - 1.9 7.3 8.2 1.9 7.3 8.2 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor RBP_receptor PF14752.6 CDI75784.1 - 2.1 6.8 7.4 2.4 6.6 7.4 1.0 1 0 0 1 1 1 0 Retinol binding protein receptor DUF2232 PF09991.9 CDI75784.1 - 2.6 7.2 4.3 2.9 7.0 4.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DUF2722 PF10846.8 CDI75784.1 - 2.9 6.7 29.7 4 6.3 29.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) EphA2_TM PF14575.6 CDI75784.1 - 3 8.8 7.7 3.9 8.4 7.7 1.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Kei1 PF08552.11 CDI75784.1 - 3.1 7.7 7.3 3.6 7.4 7.3 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 PepSY_TM PF03929.16 CDI75784.1 - 3.5 7.2 5.9 3.9 7.0 5.9 1.2 1 0 0 1 1 1 0 PepSY-associated TM region DivIC PF04977.15 CDI75784.1 - 5 7.0 18.4 7.9 6.3 18.4 1.2 1 0 0 1 1 1 0 Septum formation initiator TERB2 PF15101.6 CDI75784.1 - 7.3 6.6 15.6 9.5 6.2 15.6 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Ndc1_Nup PF09531.10 CDI75785.1 - 0.024 13.4 13.9 0.031 13.0 13.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SpoIIP PF07454.11 CDI75785.1 - 0.026 14.0 9.9 0.031 13.7 9.9 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF2235 PF09994.9 CDI75785.1 - 0.026 13.9 1.4 0.028 13.8 1.4 1.1 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) CDC45 PF02724.14 CDI75785.1 - 0.045 12.1 5.7 0.049 11.9 5.7 1.3 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.9 CDI75785.1 - 0.11 11.1 11.8 0.14 10.7 11.8 1.1 1 0 0 1 1 1 0 Macoilin family PIG-S PF10510.9 CDI75785.1 - 0.17 10.7 13.3 0.21 10.4 13.3 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein PTS_EIIC PF02378.18 CDI75785.1 - 0.19 10.7 3.0 0.29 10.1 3.0 1.4 1 0 0 1 1 1 0 Phosphotransferase system, EIIC Plasmodium_Vir PF05795.11 CDI75785.1 - 0.21 11.0 5.3 0.28 10.5 5.3 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Apt1 PF10351.9 CDI75785.1 - 0.24 10.2 6.8 0.29 9.9 6.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MDM10 PF12519.8 CDI75785.1 - 0.25 10.2 7.2 0.29 10.0 7.2 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 TFB6 PF17110.5 CDI75785.1 - 0.25 11.1 9.1 0.34 10.6 9.1 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH UPF0560 PF10577.9 CDI75785.1 - 0.3 9.5 16.5 0.31 9.5 16.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Lin-8 PF03353.15 CDI75785.1 - 0.4 10.2 18.3 0.54 9.8 18.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ferlin_C PF16165.5 CDI75785.1 - 0.51 10.3 2.7 1 9.3 2.7 1.5 1 0 0 1 1 1 0 Ferlin C-terminus MDM31_MDM32 PF08118.11 CDI75785.1 - 0.52 8.9 6.4 0.68 8.5 6.4 1.3 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins SOBP PF15279.6 CDI75785.1 - 0.55 10.8 13.2 0.82 10.2 13.2 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein GPCR_chapero_1 PF11904.8 CDI75785.1 - 0.62 9.5 6.3 0.7 9.3 6.3 1.1 1 0 0 1 1 1 0 GPCR-chaperone Otopetrin PF03189.13 CDI75785.1 - 0.71 8.6 3.6 0.77 8.5 3.6 1.2 1 0 0 1 1 1 0 Otopetrin SLC12 PF03522.15 CDI75785.1 - 0.74 8.8 12.1 0.86 8.5 12.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 UNC-79 PF14776.6 CDI75785.1 - 0.78 8.4 7.3 1 8.0 7.3 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 MMR1 PF08505.10 CDI75785.1 - 0.82 9.9 17.4 1.1 9.5 17.4 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein ALMT PF11744.8 CDI75785.1 - 0.87 8.4 8.6 1 8.1 8.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Mitofilin PF09731.9 CDI75785.1 - 0.92 8.3 30.8 1.2 7.9 30.8 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein XRN_M PF17846.1 CDI75785.1 - 0.97 8.3 9.4 1.2 8.0 9.4 1.2 1 0 0 1 1 1 0 Xrn1 helical domain FAM176 PF14851.6 CDI75785.1 - 1.3 8.7 13.1 0.43 10.2 8.3 2.2 2 0 0 2 2 2 0 FAM176 family DUF2126 PF09899.9 CDI75785.1 - 1.5 6.8 6.4 1.6 6.7 6.4 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) FAM91_C PF14648.6 CDI75785.1 - 1.5 7.5 6.7 2 7.2 6.7 1.1 1 0 0 1 1 1 0 FAM91 C-terminus DNApol_Exo PF18136.1 CDI75785.1 - 1.6 7.8 10.3 2.3 7.3 10.3 1.3 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain BASP1 PF05466.12 CDI75785.1 - 1.6 8.7 42.4 2.1 8.3 42.4 1.1 1 0 0 1 1 1 0 Brain acid soluble protein 1 (BASP1 protein) RLL PF10036.9 CDI75785.1 - 1.7 8.5 17.4 2.4 8.0 17.4 1.2 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein Membralin PF09746.9 CDI75785.1 - 2.1 7.3 5.1 2.7 6.9 5.1 1.2 1 0 0 1 1 1 0 Tumour-associated protein SpoIIIAH PF12685.7 CDI75785.1 - 2.2 8.0 21.1 3.3 7.5 21.1 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein V_ATPase_I PF01496.19 CDI75785.1 - 2.5 5.9 13.8 3.4 5.5 13.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PIP5K PF01504.18 CDI75785.1 - 3.5 6.8 10.7 5.3 6.2 10.7 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase WASH-7_C PF14746.6 CDI75785.1 - 3.8 7.2 14.0 5.7 6.6 14.0 1.2 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal DUF572 PF04502.13 CDI75785.1 - 4 7.0 16.4 5.6 6.5 16.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) NPR3 PF03666.13 CDI75785.1 - 4 6.1 12.4 7.1 5.3 12.4 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 LMBR1 PF04791.16 CDI75785.1 - 4.3 6.1 4.7 5.1 5.9 4.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein MFS_1 PF07690.16 CDI75785.1 - 4.5 6.1 23.0 0.49 9.3 10.6 2.4 1 1 1 2 2 2 0 Major Facilitator Superfamily BAF1_ABF1 PF04684.13 CDI75785.1 - 4.5 6.2 18.9 7.1 5.6 18.9 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF5312 PF17239.2 CDI75785.1 - 4.9 5.4 16.3 6.7 4.9 16.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5312) Connexin PF00029.19 CDI75785.1 - 5.6 6.6 11.0 9.6 5.9 11.0 1.3 1 0 0 1 1 1 0 Connexin Draxin PF15550.6 CDI75785.1 - 6.3 6.6 11.9 7.9 6.3 11.9 1.2 1 0 0 1 1 1 0 Draxin DUF4813 PF16072.5 CDI75785.1 - 6.5 6.3 31.3 9.4 5.8 31.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) PCM1_C PF15717.5 CDI75785.1 - 7 5.2 20.8 8.5 4.9 20.8 1.1 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Peptidase_S49_N PF08496.10 CDI75785.1 - 7.1 6.7 12.4 14 5.8 12.4 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal EMC3_TMCO1 PF01956.16 CDI75785.1 - 7.8 6.2 10.2 9.7 5.9 10.2 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like GNAT_acetyltr_2 PF13718.6 CDI75785.1 - 7.8 5.8 10.2 13 5.2 10.2 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Pex14_N PF04695.13 CDI75785.1 - 8.2 7.1 33.0 4.6 7.9 3.2 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RAP1 PF07218.11 CDI75786.1 - 0.012 13.9 19.7 0.0052 15.2 6.7 2.3 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) SUIM_assoc PF16619.5 CDI75786.1 - 0.022 14.8 9.0 0.022 14.8 9.0 12.6 5 3 3 8 8 8 0 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI75787.1 - 0.0018 18.6 38.7 0.091 13.1 4.1 3.3 1 1 1 2 2 2 2 Anti-sigma-K factor rskA ASC PF00858.24 CDI75787.1 - 1 8.2 4.7 1.6 7.6 4.7 1.2 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Spt20 PF12090.8 CDI75787.1 - 1.6 8.3 50.3 0.69 9.5 15.4 2.8 3 0 0 3 3 3 0 Spt20 family SID-1_RNA_chan PF13965.6 CDI75787.1 - 2.6 6.4 8.5 0.16 10.3 2.0 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 BAF1_ABF1 PF04684.13 CDI75787.1 - 5 6.1 43.2 0.77 8.8 24.5 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor DUF2722 PF10846.8 CDI75787.1 - 6.2 5.6 45.8 0.64 8.9 16.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI75788.1 - 0.012 15.6 1.3 0.012 15.6 1.3 2.2 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI75788.1 - 0.26 10.9 3.9 0.41 10.2 3.9 1.3 1 0 0 1 1 1 0 Spt20 family RskA PF10099.9 CDI75789.1 - 0.21 11.9 19.2 0.34 11.2 19.2 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Arabinose_trans PF04602.12 CDI75789.1 - 1.9 7.2 8.9 2.7 6.7 8.9 1.1 1 0 0 1 1 1 0 Mycobacterial cell wall arabinan synthesis protein NVEALA PF14055.6 CDI75789.1 - 9.3 6.3 11.8 2.5 8.1 0.7 3.7 2 1 1 3 3 3 0 NVEALA protein Hid1 PF12722.7 CDI75790.1 - 0.023 12.9 47.8 0.027 12.6 47.8 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CDI75790.1 - 0.13 9.3 50.8 0.16 9.1 50.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Dapper PF15268.6 CDI75790.1 - 0.44 9.4 59.9 0.52 9.1 59.9 1.0 1 0 0 1 1 1 0 Dapper SRP-alpha_N PF04086.13 CDI75790.1 - 0.68 9.8 50.0 1.2 9.0 50.0 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Asp-B-Hydro_N PF05279.11 CDI75790.1 - 3 7.9 52.4 4 7.4 52.4 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SR-25 PF10500.9 CDI75791.1 - 0.0069 16.0 47.0 0.027 14.1 25.4 2.1 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI75791.1 - 0.019 15.3 0.0 0.019 15.3 0.0 2.3 1 1 0 2 2 2 0 Anti-sigma-K factor rskA ASD2 PF08687.11 CDI75791.1 - 0.39 10.2 24.0 0.052 13.1 17.7 2.0 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Cwf_Cwc_15 PF04889.12 CDI75791.1 - 1.1 8.9 19.5 0.12 12.1 12.7 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Peroxin-3 PF04882.12 CDI75791.1 - 1.8 7.5 34.1 0.025 13.6 22.8 2.0 2 0 0 2 2 2 0 Peroxin-3 Apt1 PF10351.9 CDI75791.1 - 4.8 5.9 24.6 3.5 6.4 18.0 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain SURF6 PF04935.12 CDI75791.1 - 4.9 6.9 24.4 18 5.0 22.7 2.0 2 0 0 2 2 2 0 Surfeit locus protein 6 IMUP PF15761.5 CDI75791.1 - 5.6 7.7 35.2 5.6 7.7 10.0 2.5 2 1 0 2 2 2 0 Immortalisation up-regulated protein DUF1180 PF06679.12 CDI75791.1 - 6.9 7.0 19.9 6.1 7.2 12.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1180) DUF3995 PF13160.6 CDI75792.1 - 3.1 8.2 15.3 0.6 10.5 8.8 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3995) RCR PF12273.8 CDI75794.1 - 0.015 15.9 0.5 0.015 15.9 0.5 3.3 3 1 0 3 3 3 0 Chitin synthesis regulation, resistance to Congo red eIF-3_zeta PF05091.12 CDI75794.1 - 0.028 13.4 48.5 0.024 13.6 28.9 3.1 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RRP36 PF06102.12 CDI75794.1 - 0.34 10.9 43.8 0.028 14.4 27.4 2.5 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 Ferlin_C PF16165.5 CDI75794.1 - 1.8 8.5 0.0 1.8 8.5 0.0 3.2 2 1 0 2 2 2 0 Ferlin C-terminus Nramp PF01566.18 CDI75797.1 - 0.01 14.8 0.3 0.01 14.8 0.3 1.7 1 1 1 2 2 2 0 Natural resistance-associated macrophage protein SR-25 PF10500.9 CDI75797.1 - 0.93 9.1 29.8 2.2 7.8 29.8 1.6 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Serinc PF03348.15 CDI75797.1 - 4.3 6.1 15.9 5.9 5.7 15.9 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) SR-25 PF10500.9 CDI75798.1 - 0.0021 17.7 40.4 0.0043 16.7 6.2 3.1 3 0 0 3 3 3 3 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI75798.1 - 6.8 7.4 37.0 6.1 7.6 4.6 3.3 3 0 0 3 3 3 0 Immortalisation up-regulated protein STALD PF18185.1 CDI75799.1 - 0.0035 16.7 1.6 1 8.7 0.1 3.0 2 0 0 2 2 2 2 Sir2- and TIR-associating SLOG family Spt20 PF12090.8 CDI75799.1 - 0.004 16.8 3.4 0.004 16.8 3.4 6.0 5 1 0 5 5 5 3 Spt20 family ISN1 PF06437.11 CDI75799.1 - 0.026 13.5 12.3 0.51 9.2 1.9 2.4 2 0 0 2 2 2 0 IMP-specific 5'-nucleotidase Ureide_permease PF07168.11 CDI75799.1 - 1.3 7.7 5.3 13 4.5 0.5 2.8 2 0 0 2 2 2 0 Ureide permease RRM_7 PF16367.5 CDI75799.1 - 2.9 8.1 5.2 41 4.4 0.7 2.9 2 0 0 2 2 2 0 RNA recognition motif SID-1_RNA_chan PF13965.6 CDI75799.1 - 9.7 4.5 5.9 2.9 6.2 0.5 2.3 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Radical_SAM_C PF16199.5 CDI75800.1 - 2.1e-17 62.9 0.0 4e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain RskA PF10099.9 CDI75801.1 - 0.00085 19.7 0.3 0.00099 19.4 0.3 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA PPP4R2 PF09184.11 CDI75801.1 - 2.4 7.7 19.9 3.4 7.2 19.9 1.3 1 0 0 1 1 1 0 PPP4R2 Hid1 PF12722.7 CDI75801.1 - 4.3 5.4 23.4 5.1 5.1 23.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TRAP_alpha PF03896.16 CDI75802.1 - 1.8 7.7 13.8 2.4 7.3 13.8 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CLN3 PF02487.17 CDI75802.1 - 2.6 7.0 26.4 3.1 6.7 26.4 1.1 1 0 0 1 1 1 0 CLN3 protein Apt1 PF10351.9 CDI75802.1 - 2.9 6.6 23.7 3 6.6 23.7 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain FAM76 PF16046.5 CDI75802.1 - 3 7.1 35.5 4.1 6.7 35.5 1.2 1 0 0 1 1 1 0 FAM76 protein DUF2052 PF09747.9 CDI75802.1 - 4 7.5 32.5 4.4 7.4 32.5 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF913 PF06025.12 CDI75802.1 - 4.6 6.1 20.7 5.6 5.8 20.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 CDI75802.1 - 4.6 5.9 41.9 5.6 5.6 41.9 1.0 1 0 0 1 1 1 0 Presenilin Rtf2 PF04641.12 CDI75802.1 - 5.4 6.3 29.4 6.2 6.1 29.4 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2828 PF11443.8 CDI75802.1 - 5.7 4.9 30.7 6.7 4.7 30.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Gti1_Pac2 PF09729.9 CDI75802.1 - 9 6.3 29.5 13 5.9 29.5 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4746 PF15928.5 CDI75802.1 - 9.1 5.6 25.8 12 5.2 25.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) V_ATPase_I PF01496.19 CDI75802.1 - 9.2 4.0 36.3 12 3.7 36.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-3_zeta PF05091.12 CDI75802.1 - 10 5.0 41.5 13 4.6 41.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFB6 PF17110.5 CDI75803.1 - 0.031 14.0 0.8 0.031 14.0 0.8 3.2 2 1 1 3 3 3 0 Subunit 11 of the general transcription factor TFIIH Peptidase_S64 PF08192.11 CDI75803.1 - 0.55 8.7 28.2 0.16 10.4 14.3 2.1 2 0 0 2 2 2 0 Peptidase family S64 SLC12 PF03522.15 CDI75803.1 - 1.3 7.9 34.3 1.6 7.7 7.5 2.1 2 0 0 2 2 2 0 Solute carrier family 12 PAT1 PF09770.9 CDI75803.1 - 2.1 6.5 63.7 1.9 6.7 18.1 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SID-1_RNA_chan PF13965.6 CDI75803.1 - 4.4 5.6 14.9 3.7 5.8 5.9 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 CCDC84 PF14968.6 CDI75803.1 - 4.9 6.7 28.3 0.81 9.3 12.4 2.1 2 0 0 2 2 2 0 Coiled coil protein 84 Carb_kinase PF01256.17 CDI75804.1 - 7.1e-20 71.5 0.0 7.1e-20 71.5 0.0 4.3 5 0 0 5 5 5 1 Carbohydrate kinase TFIIA PF03153.13 CDI75804.1 - 0.0021 18.2 7.0 0.0021 18.2 7.0 2.5 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI75804.1 - 0.019 14.6 26.2 0.061 12.9 13.8 2.3 2 0 0 2 2 2 0 Spt20 family Mit_KHE1 PF10173.9 CDI75804.1 - 0.26 11.3 2.9 11 6.0 0.1 3.1 3 0 0 3 3 3 0 Mitochondrial K+-H+ exchange-related AF-4 PF05110.13 CDI75804.1 - 0.72 7.9 21.8 0.17 9.9 7.9 2.2 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Hamartin PF04388.12 CDI75804.1 - 0.94 8.1 17.5 1.3 7.6 11.6 2.0 2 0 0 2 2 2 0 Hamartin protein DUF4666 PF15697.5 CDI75804.1 - 3 8.6 11.0 0.073 13.8 1.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4666) CCDC106 PF15794.5 CDI75804.1 - 3.9 7.1 12.4 0.52 10.0 3.2 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 CD20 PF04103.15 CDI75805.1 - 0.059 13.5 4.0 0.1 12.7 4.0 1.4 1 1 0 1 1 1 0 CD20-like family SID-1_RNA_chan PF13965.6 CDI75805.1 - 0.14 10.6 8.1 0.14 10.6 8.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SR-25 PF10500.9 CDI75805.1 - 0.22 11.1 18.7 0.24 11.0 18.7 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein EIF4E-T PF10477.9 CDI75805.1 - 0.4 9.4 25.4 0.38 9.5 25.4 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Folate_carrier PF01770.18 CDI75805.1 - 0.46 9.2 11.3 0.51 9.0 11.3 1.2 1 0 0 1 1 1 0 Reduced folate carrier DUF2232 PF09991.9 CDI75805.1 - 0.47 9.6 9.5 0.58 9.3 9.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) AAA_23 PF13476.6 CDI75805.1 - 0.6 10.6 15.3 0.57 10.7 15.3 1.2 1 0 0 1 1 1 0 AAA domain SelP_N PF04592.14 CDI75805.1 - 0.68 9.3 19.6 0.7 9.2 19.6 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Spem1 PF15670.5 CDI75805.1 - 0.94 9.0 16.6 0.85 9.1 16.6 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 Nucleoside_tran PF01733.18 CDI75805.1 - 1.1 8.6 5.0 1 8.7 5.0 1.1 1 0 0 1 1 1 0 Nucleoside transporter O-antigen_lig PF13425.6 CDI75805.1 - 2.2 7.0 7.1 2.3 6.9 7.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DcuA_DcuB PF03605.14 CDI75805.1 - 2.8 6.7 13.4 3.5 6.4 13.4 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter eIF-3_zeta PF05091.12 CDI75805.1 - 2.9 6.8 28.9 3.1 6.7 28.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FHIPEP PF00771.20 CDI75805.1 - 2.9 6.3 15.5 3.6 5.9 15.5 1.2 1 0 0 1 1 1 0 FHIPEP family Serinc PF03348.15 CDI75805.1 - 3.1 6.6 17.0 3.2 6.6 17.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) NEMP PF10225.9 CDI75805.1 - 3.6 7.2 7.8 3.8 7.1 7.8 1.1 1 0 0 1 1 1 0 NEMP family TraT PF05818.12 CDI75805.1 - 4.1 7.0 25.9 5.5 6.6 25.9 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein DUF913 PF06025.12 CDI75805.1 - 5.1 6.0 15.9 5.5 5.9 15.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) V_ATPase_I PF01496.19 CDI75805.1 - 8.8 4.1 20.9 8.3 4.2 20.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Velvet PF11754.8 CDI75805.1 - 9 6.1 24.1 10 5.9 24.1 1.2 1 0 0 1 1 1 0 Velvet factor RskA PF10099.9 CDI75807.1 - 1.4e-05 25.5 22.3 0.0029 17.9 1.9 2.3 2 0 0 2 2 2 2 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI75807.1 - 0.002 18.2 1.7 0.002 18.2 1.7 2.9 3 1 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 SLATT_1 PF18181.1 CDI75807.1 - 1.9 8.4 12.9 1 9.3 5.9 2.4 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 RIFIN PF02009.16 CDI75807.1 - 3.4 7.5 10.0 5.8 6.7 10.0 1.3 1 0 0 1 1 1 0 Rifin Dsh_C PF12316.8 CDI75807.1 - 8.3 6.8 31.4 0.15 12.4 18.0 2.2 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal SpoIIP PF07454.11 CDI75809.1 - 0.24 10.8 20.7 0.25 10.8 20.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Afi1 PF07792.12 CDI75809.1 - 0.49 10.9 16.6 0.53 10.8 16.6 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FHIPEP PF00771.20 CDI75809.1 - 0.75 8.2 10.6 0.92 7.9 10.6 1.1 1 0 0 1 1 1 0 FHIPEP family Connexin PF00029.19 CDI75809.1 - 0.83 9.4 16.3 1 9.1 16.3 1.1 1 0 0 1 1 1 0 Connexin GNAT_acetyltr_2 PF13718.6 CDI75809.1 - 0.86 8.9 12.6 0.93 8.8 12.6 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 CLN3 PF02487.17 CDI75809.1 - 0.89 8.5 14.8 0.97 8.4 14.8 1.0 1 0 0 1 1 1 0 CLN3 protein Pex14_N PF04695.13 CDI75809.1 - 0.89 10.2 34.1 1 10.0 34.1 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Gti1_Pac2 PF09729.9 CDI75809.1 - 0.94 9.5 15.4 0.99 9.5 15.4 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF3464 PF11947.8 CDI75809.1 - 1 9.1 18.2 1.2 8.9 18.2 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Presenilin PF01080.17 CDI75809.1 - 1 8.0 24.5 1.1 7.9 24.5 1.0 1 0 0 1 1 1 0 Presenilin DUF4746 PF15928.5 CDI75809.1 - 1.1 8.7 14.2 1 8.7 14.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) AIF_C PF14721.6 CDI75809.1 - 1.1 9.6 15.6 1.4 9.3 15.6 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Peptidase_U57 PF05582.12 CDI75809.1 - 1.1 8.4 14.0 1.2 8.4 14.0 1.0 1 0 0 1 1 1 0 YabG peptidase U57 DDHD PF02862.17 CDI75809.1 - 1.2 9.2 18.8 1.4 9.1 18.8 1.1 1 0 0 1 1 1 0 DDHD domain DUF1764 PF08576.10 CDI75809.1 - 1.3 10.0 16.9 1.8 9.5 16.9 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) CCDC53 PF10152.9 CDI75809.1 - 1.3 9.4 21.5 1.4 9.3 21.5 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex TERB2 PF15101.6 CDI75809.1 - 1.3 9.0 26.3 1.5 8.8 26.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Paf1 PF03985.13 CDI75809.1 - 1.4 7.8 24.2 1.6 7.6 24.2 1.0 1 0 0 1 1 1 0 Paf1 TMEM174 PF15029.6 CDI75809.1 - 1.6 8.4 7.0 1.7 8.3 7.0 1.0 1 0 0 1 1 1 0 Transmembrane protein 174 RR_TM4-6 PF06459.12 CDI75809.1 - 1.7 8.4 20.5 1.8 8.3 20.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 EIIBC-GUT_N PF03612.14 CDI75809.1 - 1.8 8.3 16.5 2.2 8.0 16.5 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CobT PF06213.12 CDI75809.1 - 1.8 7.9 30.2 2 7.8 30.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pannexin_like PF12534.8 CDI75809.1 - 1.9 7.5 13.1 2.1 7.3 13.1 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Band_3_cyto PF07565.13 CDI75809.1 - 2 8.1 18.7 2 8.1 18.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TFB6 PF17110.5 CDI75809.1 - 2 8.1 11.3 2.4 7.9 11.3 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF913 PF06025.12 CDI75809.1 - 2.1 7.2 14.6 2.2 7.2 14.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2828 PF11443.8 CDI75809.1 - 2.1 6.3 19.3 2.3 6.2 19.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SLC12 PF03522.15 CDI75809.1 - 2.2 7.2 19.5 2.2 7.2 19.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 CDI75809.1 - 2.3 7.0 15.0 2.4 6.9 15.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CPSF100_C PF13299.6 CDI75809.1 - 2.3 8.4 17.5 2.4 8.3 17.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Tim54 PF11711.8 CDI75809.1 - 2.3 6.9 19.0 2.6 6.7 19.0 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NARP1 PF12569.8 CDI75809.1 - 2.4 7.0 18.6 2.5 6.9 18.6 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF3408 PF11888.8 CDI75809.1 - 2.9 8.1 20.0 3.2 7.9 20.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Baculo_PP31 PF05311.11 CDI75809.1 - 2.9 7.3 19.1 3.1 7.2 19.1 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) FAM176 PF14851.6 CDI75809.1 - 3.2 7.4 13.1 4 7.1 13.1 1.1 1 0 0 1 1 1 0 FAM176 family Membralin PF09746.9 CDI75809.1 - 3.2 6.7 13.3 3.3 6.7 13.3 1.0 1 0 0 1 1 1 0 Tumour-associated protein SID-1_RNA_chan PF13965.6 CDI75809.1 - 3.3 6.0 10.5 3.5 5.9 10.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 N6_N4_Mtase PF01555.18 CDI75809.1 - 3.4 7.3 8.3 4.1 7.1 8.3 1.2 1 0 0 1 1 1 0 DNA methylase NPR3 PF03666.13 CDI75809.1 - 3.4 6.3 18.8 3.5 6.3 18.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3405 PF11885.8 CDI75809.1 - 3.6 6.1 18.1 3.9 6.0 18.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) eIF-3_zeta PF05091.12 CDI75809.1 - 3.6 6.5 29.7 3.6 6.5 29.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) YABBY PF04690.13 CDI75809.1 - 3.9 8.0 16.6 4.3 7.9 16.6 1.1 1 0 0 1 1 1 0 YABBY protein CDC45 PF02724.14 CDI75809.1 - 4.1 5.6 16.9 3.6 5.8 16.9 1.0 1 0 0 1 1 1 0 CDC45-like protein V_ATPase_I PF01496.19 CDI75809.1 - 4.1 5.2 23.9 4.9 4.9 23.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MMU163 PF17119.5 CDI75809.1 - 4.2 6.4 10.5 4.3 6.4 10.5 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Eapp_C PF10238.9 CDI75809.1 - 4.4 7.4 20.6 6.1 6.9 20.6 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein Peptidase_S64 PF08192.11 CDI75809.1 - 4.6 5.6 16.2 4.9 5.5 16.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 PTPRCAP PF15713.5 CDI75809.1 - 4.6 7.5 21.4 4.5 7.5 21.4 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Ketoacyl-synt_2 PF13723.6 CDI75809.1 - 4.8 6.8 17.7 5.4 6.6 17.7 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain Ctr PF04145.15 CDI75809.1 - 4.8 7.8 12.8 5.3 7.7 12.8 1.2 1 0 0 1 1 1 0 Ctr copper transporter family MDM10 PF12519.8 CDI75809.1 - 4.8 5.9 16.9 5.3 5.8 16.9 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 EPL1 PF10513.9 CDI75809.1 - 4.9 7.5 22.0 5.9 7.3 22.0 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like Pal1 PF08316.11 CDI75809.1 - 5 7.9 10.4 5.4 7.8 10.4 1.2 1 0 0 1 1 1 0 Pal1 cell morphology protein Peptidase_S49_N PF08496.10 CDI75809.1 - 5.1 7.1 17.8 6.4 6.8 17.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Endostatin PF06482.11 CDI75809.1 - 5.3 6.4 20.7 5.7 6.3 20.7 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Peroxin-13_N PF04088.13 CDI75809.1 - 5.6 7.2 13.1 7 6.9 13.1 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region STAC2_u1 PF16664.5 CDI75809.1 - 5.7 7.4 14.9 5.8 7.4 14.9 1.1 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 FAM60A PF15396.6 CDI75809.1 - 5.7 6.9 17.0 6.2 6.8 17.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CBP_BcsG PF11658.8 CDI75809.1 - 5.8 5.2 15.4 6.4 5.1 15.4 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG API5 PF05918.11 CDI75809.1 - 5.9 5.6 21.0 6.5 5.4 21.0 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF3043 PF11241.8 CDI75809.1 - 6 6.9 14.5 6.8 6.7 14.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Neur_chan_memb PF02932.16 CDI75809.1 - 6 6.9 17.3 6.4 6.8 17.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2072 PF09845.9 CDI75809.1 - 6.1 7.1 15.5 6.9 6.9 15.5 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein CSG2 PF16965.5 CDI75809.1 - 6.8 5.5 12.2 6.7 5.5 12.2 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator EOS1 PF12326.8 CDI75809.1 - 7.5 6.4 12.7 7.9 6.4 12.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein PIP5K PF01504.18 CDI75809.1 - 7.5 5.7 19.8 8.9 5.4 19.8 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2126 PF09899.9 CDI75809.1 - 7.8 4.4 15.7 8.2 4.4 15.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Mem_trans PF03547.18 CDI75809.1 - 7.9 4.8 7.2 8.4 4.7 7.2 1.0 1 0 0 1 1 1 0 Membrane transport protein DUF4407 PF14362.6 CDI75809.1 - 8 5.7 23.8 8 5.7 23.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Velvet PF11754.8 CDI75809.1 - 8.3 6.3 21.5 8.7 6.2 21.5 1.1 1 0 0 1 1 1 0 Velvet factor DUF4824 PF16106.5 CDI75809.1 - 9.4 5.4 22.2 9.6 5.4 22.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4824) Serinc PF03348.15 CDI75809.1 - 9.4 5.0 13.9 9.3 5.1 13.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4638 PF15472.6 CDI75809.1 - 9.7 5.8 17.9 9.7 5.8 17.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) RAP1 PF07218.11 CDI75811.1 - 0.014 13.7 9.8 0.015 13.6 9.8 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Exonuc_VII_L PF02601.15 CDI75812.1 - 6.5 6.2 0.0 6.5 6.2 0.0 4.2 4 1 0 5 5 5 0 Exonuclease VII, large subunit EPL1 PF10513.9 CDI75813.1 - 0.74 10.2 22.8 0.064 13.6 15.3 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like SpoIIP PF07454.11 CDI75813.1 - 1.6 8.1 20.8 0.17 11.3 16.2 1.7 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF4746 PF15928.5 CDI75813.1 - 1.9 7.8 12.5 0.11 11.9 6.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Plasmodium_Vir PF05795.11 CDI75813.1 - 2.4 7.5 9.6 4.1 6.7 9.6 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein eIF-3_zeta PF05091.12 CDI75813.1 - 4.1 6.3 35.2 2.2 7.1 25.1 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4471 PF14740.6 CDI75813.1 - 9.6 5.3 15.6 0.42 9.8 9.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) PH PF00169.29 CDI75814.1 - 1.3e-09 38.5 0.0 1.9e-05 25.1 0.0 3.2 1 1 1 3 3 3 2 PH domain BUD22 PF09073.10 CDI75814.1 - 2.1 7.6 24.4 3.1 7.1 24.4 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 CDI75814.1 - 2.7 7.3 26.4 4.2 6.7 26.4 1.2 1 0 0 1 1 1 0 SDA1 DKCLD PF08068.12 CDI75815.1 - 4.7e-29 100.2 0.1 6.9e-29 99.7 0.1 1.3 1 0 0 1 1 1 1 DKCLD (NUC011) domain TruB_N PF01509.18 CDI75815.1 - 4.6e-12 46.5 0.2 5.7e-12 46.2 0.2 1.1 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) Kinesin PF00225.23 CDI75816.1 - 1.3e-104 349.8 0.0 1.6e-104 349.4 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDI75816.1 - 2.4e-25 89.2 0.0 4.3e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding TFIIA PF03153.13 CDI75816.1 - 1.3 8.9 10.6 1.2 9.1 6.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit ThrE PF06738.12 CDI75817.1 - 0.12 11.7 0.3 0.16 11.3 0.3 1.2 1 0 0 1 1 1 0 Putative threonine/serine exporter SARAF PF06682.12 CDI75818.1 - 0.00055 19.7 0.2 0.00055 19.7 0.2 4.5 3 2 1 4 4 3 1 SOCE-associated regulatory factor of calcium homoeostasis Med15 PF09606.10 CDI75818.1 - 0.00075 18.3 33.8 0.00075 18.3 33.8 5.0 2 1 1 4 4 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal MscS_TM PF12794.7 CDI75818.1 - 0.0019 17.1 0.6 0.0019 17.1 0.6 6.4 6 1 1 7 7 2 1 Mechanosensitive ion channel inner membrane domain 1 DUF4834 PF16118.5 CDI75818.1 - 0.0049 17.8 0.0 0.0049 17.8 0.0 7.2 6 1 1 7 7 6 1 Domain of unknown function (DUF4834) Conotoxin PF02950.17 CDI75818.1 - 0.012 16.6 2.6 0.012 16.6 2.6 7.4 6 1 1 7 7 6 0 Conotoxin DUF2681 PF10883.8 CDI75818.1 - 0.018 15.4 8.7 0.018 15.4 8.7 7.6 6 1 1 7 7 5 0 Protein of unknown function (DUF2681) CNDH2_C PF16858.5 CDI75818.1 - 0.058 13.3 0.0 0.058 13.3 0.0 5.2 2 2 1 4 4 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term EphA2_TM PF14575.6 CDI75818.1 - 0.093 13.6 0.1 0.093 13.6 0.1 6.9 6 1 0 6 6 5 0 Ephrin type-A receptor 2 transmembrane domain NicO PF03824.16 CDI75818.1 - 0.11 11.8 0.0 0.11 11.8 0.0 4.6 4 1 0 4 4 4 0 High-affinity nickel-transport protein Acatn PF13000.7 CDI75818.1 - 0.19 10.2 0.5 0.68 8.4 0.5 1.9 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 DUF3169 PF11368.8 CDI75818.1 - 0.39 10.2 0.0 0.39 10.2 0.0 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3169) Tmemb_9 PF05434.11 CDI75818.1 - 0.42 10.5 0.0 0.42 10.5 0.0 5.6 6 0 0 6 6 6 0 TMEM9 FAM176 PF14851.6 CDI75818.1 - 0.44 10.2 0.0 0.44 10.2 0.0 5.6 6 0 0 6 6 6 0 FAM176 family Cadherin_C_2 PF16492.5 CDI75818.1 - 0.57 11.0 0.0 0.57 11.0 0.0 4.5 5 0 0 5 5 5 0 Cadherin cytoplasmic C-terminal Pex24p PF06398.11 CDI75818.1 - 0.94 8.4 0.0 0.94 8.4 0.0 2.3 2 1 0 2 2 2 0 Integral peroxisomal membrane peroxin SID-1_RNA_chan PF13965.6 CDI75818.1 - 1.4 7.3 0.0 1.4 7.3 0.0 3.5 3 1 0 3 3 2 0 dsRNA-gated channel SID-1 DUF4179 PF13786.6 CDI75818.1 - 2.1 8.9 0.0 2.1 8.9 0.0 8.1 7 2 0 7 7 4 0 Domain of unknown function (DUF4179) rRNA_processing PF08524.11 CDI75818.1 - 2.8 8.0 63.8 2.9 7.9 0.1 6.2 6 0 0 6 6 6 0 rRNA processing FmiP_Thoc5 PF09766.9 CDI75819.1 - 0.0038 16.6 8.6 0.0043 16.4 8.6 1.0 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 TRAP_alpha PF03896.16 CDI75819.1 - 0.11 11.6 12.5 0.12 11.6 12.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BSMAP PF12280.8 CDI75819.1 - 0.24 11.6 3.9 0.24 11.6 3.9 1.1 1 0 0 1 1 1 0 Brain specific membrane anchored protein NOA36 PF06524.12 CDI75819.1 - 0.33 10.2 16.1 0.39 10.0 16.1 1.2 1 0 0 1 1 1 0 NOA36 protein RNA_pol_Rpc4 PF05132.14 CDI75819.1 - 0.33 11.4 7.1 0.41 11.1 7.1 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Calc_CGRP_IAPP PF00214.19 CDI75819.1 - 0.36 11.2 1.4 0.45 10.9 1.4 1.2 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family FHIPEP PF00771.20 CDI75819.1 - 0.37 9.2 2.4 0.37 9.2 2.4 1.1 1 0 0 1 1 1 0 FHIPEP family DUF4746 PF15928.5 CDI75819.1 - 0.4 10.0 21.1 0.45 9.9 21.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TLP-20 PF06088.11 CDI75819.1 - 0.61 10.0 7.9 0.69 9.8 7.9 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) PPL5 PF18168.1 CDI75819.1 - 0.69 9.2 9.0 0.7 9.1 9.0 1.0 1 0 0 1 1 1 0 Prim-pol family 5 Nop14 PF04147.12 CDI75819.1 - 0.84 7.8 24.5 0.84 7.8 24.5 1.0 1 0 0 1 1 1 0 Nop14-like family Rrp15p PF07890.12 CDI75819.1 - 0.86 9.9 11.9 0.98 9.8 11.9 1.1 1 0 0 1 1 1 0 Rrp15p V_ATPase_I PF01496.19 CDI75819.1 - 0.87 7.4 8.3 0.92 7.3 8.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1770 PF08589.10 CDI75819.1 - 1 10.4 6.1 1.3 10.0 6.1 1.3 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1770) Tim54 PF11711.8 CDI75819.1 - 1 8.0 13.6 1 8.1 13.6 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 HA2 PF04408.23 CDI75819.1 - 1.2 9.4 9.9 2.1 8.6 9.9 1.4 1 1 0 1 1 1 0 Helicase associated domain (HA2) CobT PF06213.12 CDI75819.1 - 1.2 8.4 22.1 1.3 8.3 22.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PSK PF06404.12 CDI75819.1 - 1.4 9.9 12.2 1.7 9.7 12.2 1.1 1 0 0 1 1 1 0 Phytosulfokine precursor protein (PSK) Presenilin PF01080.17 CDI75819.1 - 1.5 7.5 10.6 1.5 7.5 10.6 1.0 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 CDI75819.1 - 1.8 7.7 11.2 2.2 7.4 11.2 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter RPN2_C PF18004.1 CDI75819.1 - 1.9 8.4 17.2 2.4 8.0 17.2 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DDHD PF02862.17 CDI75819.1 - 2 8.5 4.9 2.2 8.4 4.9 1.1 1 0 0 1 1 1 0 DDHD domain DUF5523 PF17661.1 CDI75819.1 - 2.4 7.8 23.7 2.4 7.8 23.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF913 PF06025.12 CDI75819.1 - 2.4 7.0 9.9 2.6 6.9 9.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Spore_coat_CotO PF14153.6 CDI75819.1 - 2.6 7.9 21.4 2.9 7.8 21.4 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Serinc PF03348.15 CDI75819.1 - 2.9 6.7 6.3 3.2 6.6 6.3 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) CLN3 PF02487.17 CDI75819.1 - 3.2 6.7 4.8 2.8 6.9 4.8 1.0 1 0 0 1 1 1 0 CLN3 protein DUF2428 PF10350.9 CDI75819.1 - 3.4 6.9 6.6 3.6 6.8 6.6 1.1 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) SURF2 PF05477.11 CDI75819.1 - 3.8 7.1 13.8 4.4 6.9 13.8 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DUF4820 PF16091.5 CDI75819.1 - 3.8 6.8 11.6 4.2 6.7 11.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Saw1 PF11561.8 CDI75819.1 - 4 6.9 9.7 4.4 6.8 9.7 1.1 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Vfa1 PF08432.10 CDI75819.1 - 4.2 7.7 15.3 4.4 7.6 15.3 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF3464 PF11947.8 CDI75819.1 - 4.4 7.0 8.0 5.4 6.7 8.0 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 AIF_C PF14721.6 CDI75819.1 - 4.6 7.6 8.9 5.4 7.4 8.9 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4366 PF14283.6 CDI75819.1 - 5.5 7.0 11.8 7.3 6.6 11.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) EIIBC-GUT_N PF03612.14 CDI75819.1 - 5.6 6.7 8.5 6.9 6.4 8.5 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CDC45 PF02724.14 CDI75819.1 - 5.7 5.1 20.2 5.8 5.1 20.2 1.0 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 CDI75819.1 - 6.2 6.1 21.7 7.1 5.9 21.7 1.0 1 0 0 1 1 1 0 BUD22 TFB6 PF17110.5 CDI75819.1 - 6.3 6.5 11.9 7.5 6.3 11.9 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RNA_pol_3_Rpc31 PF11705.8 CDI75819.1 - 8.7 6.5 27.1 11 6.2 27.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RR_TM4-6 PF06459.12 CDI75819.1 - 8.7 6.1 18.5 9.3 6.0 18.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ATG22 PF11700.8 CDI75819.1 - 9.1 4.8 5.7 11 4.6 5.7 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like Sec62 PF03839.16 CDI75819.1 - 9.2 5.7 7.5 9.1 5.7 7.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 RskA PF10099.9 CDI75821.1 - 8.7e-07 29.4 2.3 8.7e-07 29.4 2.3 2.7 1 1 1 2 2 2 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI75821.1 - 4.1e-05 23.3 24.7 4.4e-05 23.2 15.6 2.3 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein Cwf_Cwc_15 PF04889.12 CDI75821.1 - 0.36 10.5 30.9 0.26 11.0 13.7 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SPX PF03105.19 CDI75821.1 - 0.54 10.1 25.1 0.85 9.5 25.1 1.2 1 0 0 1 1 1 0 SPX domain Spem1 PF15670.5 CDI75821.1 - 0.96 9.0 21.2 1.4 8.4 15.5 2.2 2 0 0 2 2 2 0 Spermatid maturation protein 1 Utp14 PF04615.13 CDI75821.1 - 8.6 4.8 26.6 13 4.2 26.6 1.2 1 0 0 1 1 1 0 Utp14 protein YtxH PF12732.7 CDI75822.1 - 0.05 14.1 0.9 0.05 14.1 0.9 3.2 2 1 1 3 3 3 0 YtxH-like protein DUF4805 PF16063.5 CDI75823.1 - 0.0081 15.5 5.9 0.0081 15.5 5.9 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4805) Nop14 PF04147.12 CDI75824.1 - 0.0057 15.0 33.8 0.0058 14.9 33.8 1.0 1 0 0 1 1 1 1 Nop14-like family Mpp10 PF04006.12 CDI75824.1 - 0.016 13.7 34.9 0.019 13.5 34.9 1.0 1 0 0 1 1 1 0 Mpp10 protein BORG_CEP PF14957.6 CDI75824.1 - 0.11 13.6 4.5 0.13 13.4 4.5 1.2 1 0 0 1 1 1 0 Cdc42 effector SDA1 PF05285.12 CDI75824.1 - 0.48 9.8 37.9 0.57 9.6 37.9 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 CDI75824.1 - 0.59 9.4 31.4 0.65 9.3 31.4 1.0 1 0 0 1 1 1 0 BUD22 CCSAP PF15748.5 CDI75824.1 - 0.69 10.0 21.5 0.75 9.9 21.5 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CDC45 PF02724.14 CDI75824.1 - 0.74 8.0 30.9 0.8 7.9 30.9 1.0 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 CDI75824.1 - 0.84 9.4 26.7 1.1 9.0 26.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CSRNP_N PF16019.5 CDI75824.1 - 0.87 9.5 8.2 1.1 9.1 8.2 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF4045 PF13254.6 CDI75824.1 - 0.92 9.1 17.3 1 8.9 17.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Raftlin PF15250.6 CDI75824.1 - 1 8.1 16.9 1.1 7.9 16.9 1.0 1 0 0 1 1 1 0 Raftlin DUF913 PF06025.12 CDI75824.1 - 1.4 7.8 12.4 1.8 7.4 12.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 CDI75824.1 - 1.7 8.6 7.1 2.1 8.3 7.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CKAP2_C PF15297.6 CDI75824.1 - 1.9 7.5 21.6 2.3 7.2 21.6 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus Zip PF02535.22 CDI75824.1 - 1.9 7.6 13.0 2.3 7.3 13.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter YqfQ PF14181.6 CDI75824.1 - 2.5 8.3 24.3 6.5 6.9 23.2 1.8 1 1 1 2 2 2 0 YqfQ-like protein NPR3 PF03666.13 CDI75824.1 - 2.8 6.6 15.8 3.2 6.5 15.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DHHW PF14286.6 CDI75824.1 - 2.9 7.1 10.8 3.3 6.9 10.8 1.0 1 0 0 1 1 1 0 DHHW protein DUF2828 PF11443.8 CDI75824.1 - 5.2 5.0 11.2 7 4.6 11.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Vfa1 PF08432.10 CDI75824.1 - 5.5 7.3 23.8 6.9 7.0 23.8 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SAPS PF04499.15 CDI75824.1 - 5.7 5.6 17.9 6.7 5.4 17.9 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MDM10 PF12519.8 CDI75824.1 - 7 5.4 10.1 7.2 5.3 10.1 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Hid1 PF12722.7 CDI75824.1 - 7.2 4.6 16.5 8.3 4.4 16.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SLC12 PF03522.15 CDI75824.1 - 7.7 5.4 13.9 8.6 5.3 13.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Na_trans_assoc PF06512.13 CDI75824.1 - 8 6.7 24.7 11 6.2 24.7 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated MDM1 PF15501.6 CDI75824.1 - 8.5 5.4 24.8 9.9 5.2 24.8 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 Presenilin PF01080.17 CDI75824.1 - 8.5 5.0 21.9 11 4.7 21.9 1.1 1 0 0 1 1 1 0 Presenilin RT_RNaseH_2 PF17919.1 CDI75825.1 - 3.3e-24 84.8 0.0 7e-24 83.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI75825.1 - 5.7e-21 74.8 0.0 1.1e-20 73.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDI75825.1 - 1.4e-14 54.3 0.0 4.2e-14 52.8 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDI75825.1 - 1e-13 51.1 0.2 2.4e-13 49.9 0.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 CDI75825.1 - 1.5e-09 37.7 0.0 2.8e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 CDI75826.1 - 6.1e-06 26.1 9.5 1.6e-05 24.8 4.6 2.4 2 0 0 2 2 2 2 Zinc knuckle DUF5351 PF17302.2 CDI75826.1 - 7.3 6.9 7.9 10 6.4 1.2 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5351) Pkinase PF00069.25 CDI75827.1 - 1.1e-08 34.7 0.6 2e-08 34.0 0.6 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI75827.1 - 2.6e-05 23.6 0.0 5.2e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 CDI75828.1 - 9.4e-14 49.9 0.5 1e-05 24.7 0.1 3.0 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 CDI75828.1 - 8.2e-11 42.2 0.0 1.7e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair Pkinase PF00069.25 CDI75828.1 - 6.4e-10 38.8 0.1 6.9e-09 35.4 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain EF-hand_6 PF13405.6 CDI75828.1 - 7.3e-09 34.9 0.5 0.0018 18.0 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 CDI75828.1 - 1.9e-07 30.3 0.6 0.034 13.7 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 CDI75828.1 - 1.3e-06 28.2 1.1 0.0014 18.4 0.1 3.0 2 2 1 3 3 3 2 EF-hand domain pair DUF2267 PF10025.9 CDI75828.1 - 0.0096 16.2 0.0 0.019 15.2 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2267) EF-hand_14 PF17959.1 CDI75828.1 - 0.036 14.4 0.0 0.066 13.6 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain EF-hand_4 PF12763.7 CDI75828.1 - 0.04 13.9 0.4 0.29 11.1 0.3 2.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Pkinase_Tyr PF07714.17 CDI75828.1 - 0.12 11.7 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase RskA PF10099.9 CDI75829.1 - 1.2e-08 35.4 30.1 0.054 13.8 0.0 4.4 2 2 1 4 4 4 3 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI75829.1 - 0.00018 21.2 22.1 0.00018 21.2 22.1 11.0 4 2 6 10 10 10 3 Nuclear RNA-splicing-associated protein Cwf_Cwc_15 PF04889.12 CDI75829.1 - 0.001 18.9 7.1 0.001 18.9 7.1 5.0 3 1 1 4 4 4 1 Cwf15/Cwc15 cell cycle control protein SPX PF03105.19 CDI75829.1 - 0.01 15.8 21.3 0.01 15.8 21.3 4.2 3 1 1 4 4 4 0 SPX domain DUF4064 PF13273.6 CDI75829.1 - 0.14 12.4 0.1 0.14 12.4 0.1 4.9 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) CCSAP PF15748.5 CDI75830.1 - 0.16 12.1 46.5 0.19 11.9 46.5 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated RR_TM4-6 PF06459.12 CDI75830.1 - 0.47 10.2 37.3 0.57 10.0 37.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SR-25 PF10500.9 CDI75830.1 - 1.2 8.7 46.2 25 4.4 46.2 2.0 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 CDI75830.1 - 4.1 5.6 37.3 4.9 5.3 37.3 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF572 PF04502.13 CDI75830.1 - 4.8 6.7 35.2 5.5 6.5 35.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) AAA_11 PF13086.6 CDI75830.1 - 6.6 6.4 37.6 7.7 6.2 37.6 1.0 1 0 0 1 1 1 0 AAA domain Raftlin PF15250.6 CDI75830.1 - 7.1 5.3 35.9 8.5 5.0 35.9 1.0 1 0 0 1 1 1 0 Raftlin DUF2052 PF09747.9 CDI75830.1 - 7.8 6.6 35.7 9.2 6.3 35.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) MRP-S26 PF14943.6 CDI75830.1 - 8.2 6.3 34.8 10 6.0 34.8 1.1 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Dsh_C PF12316.8 CDI75830.1 - 8.2 6.8 35.2 9.9 6.5 35.2 1.0 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Presenilin PF01080.17 CDI75830.1 - 8.3 5.1 49.7 9.4 4.9 49.7 1.0 1 0 0 1 1 1 0 Presenilin SMYLE_N PF18615.1 CDI75830.1 - 8.6 5.8 28.0 14 5.1 28.0 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain tRNA-synt_1c PF00749.21 CDI75831.1 - 2.2e-62 210.8 4.6 1.6e-32 112.7 0.0 4.6 4 1 0 4 4 4 3 tRNA synthetases class I (E and Q), catalytic domain DUF4667 PF15700.5 CDI75831.1 - 0.00017 21.8 21.4 0.0054 16.9 0.0 3.3 3 0 0 3 3 3 3 Domain of unknown function (DUF4667) DUF4484 PF14831.6 CDI75831.1 - 0.0031 17.6 4.1 0.0031 17.6 4.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4484) Serinc PF03348.15 CDI75831.1 - 1.8 7.4 4.3 3.4 6.5 4.3 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) Med15 PF09606.10 CDI75831.1 - 2.3 6.8 29.3 6.9 5.2 29.3 1.7 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SR-25 PF10500.9 CDI75833.1 - 0.00088 19.0 8.9 0.0011 18.6 8.9 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI75833.1 - 0.0089 15.7 21.1 0.011 15.3 21.1 1.2 1 0 0 1 1 1 1 Spt20 family Spem1 PF15670.5 CDI75833.1 - 0.025 14.2 4.0 0.032 13.8 4.0 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 Activator_LAG-3 PF11498.8 CDI75833.1 - 0.038 13.0 20.3 0.043 12.8 20.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 FAM199X PF15814.5 CDI75833.1 - 0.045 12.8 9.9 0.057 12.5 9.9 1.0 1 0 0 1 1 1 0 Protein family FAM199X Suf PF05843.14 CDI75833.1 - 0.046 13.7 5.8 0.043 13.8 5.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TCP PF03634.13 CDI75833.1 - 0.12 12.9 9.3 0.15 12.6 9.3 1.1 1 0 0 1 1 1 0 TCP family transcription factor TFIIA PF03153.13 CDI75833.1 - 0.14 12.2 18.2 0.16 11.9 18.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EOS1 PF12326.8 CDI75833.1 - 0.39 10.6 1.5 0.45 10.4 1.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein CCDC106 PF15794.5 CDI75833.1 - 0.46 10.2 8.5 0.62 9.7 8.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Neur_chan_memb PF02932.16 CDI75833.1 - 0.97 9.4 3.0 1 9.4 3.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Roughex PF06020.11 CDI75833.1 - 2.7 7.0 9.0 2.9 6.9 9.0 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Presenilin PF01080.17 CDI75833.1 - 4.2 6.0 11.2 4.9 5.8 11.2 1.0 1 0 0 1 1 1 0 Presenilin PvlArgDC PF01862.16 CDI75834.1 - 2.2 8.1 4.5 0.86 9.4 2.1 1.6 1 1 1 2 2 2 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) VIR_N PF15912.5 CDI75834.1 - 7.8 6.0 23.2 9.7 5.7 23.2 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal SARAF PF06682.12 CDI75835.1 - 3.2e-05 23.8 3.6 3.2e-05 23.8 3.6 3.5 1 1 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis Macoilin PF09726.9 CDI75836.1 - 0.35 9.4 22.8 0.43 9.1 22.8 1.0 1 0 0 1 1 1 0 Macoilin family Sin_N PF04801.13 CDI75836.1 - 0.89 8.7 22.4 1.1 8.4 22.4 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Lin-8 PF03353.15 CDI75836.1 - 0.98 8.9 20.5 1.6 8.2 20.5 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Med15 PF09606.10 CDI75836.1 - 1.7 7.2 33.2 2.3 6.8 33.2 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SPX PF03105.19 CDI75836.1 - 3 7.6 24.8 3.8 7.3 24.8 1.0 1 0 0 1 1 1 0 SPX domain DUF5352 PF17303.2 CDI75836.1 - 4.4 7.1 9.6 4 7.2 8.6 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF5352) Apt1 PF10351.9 CDI75836.1 - 4.6 6.0 17.3 7.5 5.3 17.3 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain PAT1 PF09770.9 CDI75836.1 - 4.9 5.3 26.4 5.7 5.1 26.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Plasmodium_Vir PF05795.11 CDI75836.1 - 7.2 5.9 13.0 9.1 5.6 13.0 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein NESP55 PF06390.12 CDI75837.1 - 1.7 8.2 19.4 2.2 7.8 19.4 1.4 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Eapp_C PF10238.9 CDI75837.1 - 5.9 7.0 11.3 6.6 6.8 11.3 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein Sec62 PF03839.16 CDI75837.1 - 8.2 5.9 11.3 8.3 5.8 11.3 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 Vfa1 PF08432.10 CDI75837.1 - 8.7 6.6 18.7 9 6.6 18.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4179 PF13786.6 CDI75838.1 - 0.019 15.5 0.0 0.025 15.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) TPPII_N PF12583.8 CDI75838.1 - 0.031 14.9 13.1 0.57 10.8 1.6 2.1 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal SR-25 PF10500.9 CDI75838.1 - 0.05 13.2 11.8 0.087 12.4 11.8 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 CDI75838.1 - 0.05 13.9 3.9 0.05 13.9 3.9 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF755) YscJ_FliF_C PF08345.11 CDI75838.1 - 0.25 11.7 7.9 0.29 11.5 7.9 1.2 1 0 0 1 1 1 0 Flagellar M-ring protein C-terminal Menin PF05053.13 CDI75838.1 - 0.82 8.0 8.2 0.95 7.8 8.2 1.0 1 0 0 1 1 1 0 Menin PXA PF02194.15 CDI75838.1 - 0.89 9.5 6.4 1 9.3 6.4 1.2 1 0 0 1 1 1 0 PXA domain TFIIA PF03153.13 CDI75838.1 - 1 9.3 26.5 1.1 9.1 26.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI75838.1 - 1 9.6 19.4 3.9 7.7 19.4 1.7 1 1 0 1 1 1 0 Anti-sigma-K factor rskA HemX PF04375.14 CDI75838.1 - 1.1 8.4 13.4 1.4 8.2 13.4 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Dehydrin PF00257.19 CDI75838.1 - 8.5 6.9 13.9 0.11 13.0 2.8 2.2 1 1 1 2 2 2 0 Dehydrin Endostatin PF06482.11 CDI75838.1 - 9.2 5.6 13.7 10 5.5 13.7 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Ribosomal_60s PF00428.19 CDI75839.1 - 0.01 16.4 23.4 0.31 11.7 11.4 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein TrbC PF04956.13 CDI75839.1 - 0.48 10.7 12.2 0.28 11.4 4.5 2.2 2 0 0 2 2 2 0 TrbC/VIRB2 family DUF572 PF04502.13 CDI75839.1 - 2.4 7.7 23.4 2.8 7.5 23.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) SR-25 PF10500.9 CDI75840.1 - 0.016 14.8 10.4 0.016 14.8 10.4 4.9 5 0 0 5 5 5 0 Nuclear RNA-splicing-associated protein CoA_binding_2 PF13380.6 CDI75840.1 - 0.14 12.7 0.3 0.14 12.7 0.3 3.5 5 0 0 5 5 5 0 CoA binding domain BRI3BP PF14965.6 CDI75840.1 - 0.38 10.2 6.7 4.2 6.9 8.2 2.0 2 0 0 2 2 2 0 Negative regulator of p53/TP53 SPX PF03105.19 CDI75840.1 - 2 8.3 24.4 1.8 8.4 13.0 2.2 2 0 0 2 2 2 0 SPX domain MAT1 PF06391.13 CDI75840.1 - 6 6.6 26.6 0.43 10.4 6.4 2.7 2 1 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 ESM4 PF15952.5 CDI75840.1 - 7.3 7.0 28.8 3.7 8.0 6.7 2.5 2 0 0 2 2 2 0 Enhancer of split M4 family Uds1 PF15456.6 CDI75841.1 - 0.12 12.6 1.9 0.27 11.4 1.3 1.7 2 0 0 2 2 2 0 Up-regulated During Septation BAG6 PF12057.8 CDI75841.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 BCL2-associated athanogene 6 Spectrin PF00435.21 CDI75842.1 - 0.068 13.7 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 Spectrin repeat REV PF00424.18 CDI75844.1 - 0.073 13.1 0.0 0.23 11.5 0.0 1.8 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) TFIIA PF03153.13 CDI75849.1 - 0.0043 17.1 10.8 0.0043 17.1 10.8 2.1 1 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Rad1 PF02144.16 CDI75849.1 - 0.034 13.2 0.9 0.07 12.2 0.8 1.5 1 1 0 1 1 1 0 Repair protein Rad1/Rec1/Rad17 YajC PF02699.15 CDI75849.1 - 2 8.3 22.2 0.41 10.6 0.9 3.3 3 0 0 3 3 3 0 Preprotein translocase subunit Dehydrin PF00257.19 CDI75849.1 - 7.6 7.1 19.8 1.2 9.6 5.2 3.1 3 0 0 3 3 3 0 Dehydrin SR-25 PF10500.9 CDI75852.1 - 0.002 17.8 60.0 0.046 13.3 20.2 2.4 1 1 1 2 2 2 2 Nuclear RNA-splicing-associated protein Utp14 PF04615.13 CDI75852.1 - 0.0077 14.9 34.0 0.012 14.3 34.0 1.2 1 0 0 1 1 1 1 Utp14 protein Caldesmon PF02029.15 CDI75852.1 - 4.7 5.9 39.9 6.7 5.3 39.9 1.1 1 0 0 1 1 1 0 Caldesmon VasI PF11319.8 CDI75853.1 - 0.0048 16.6 7.2 0.0059 16.3 7.2 1.1 1 0 0 1 1 1 1 Type VI secretion system VasI, EvfG, VC_A0118 PIP5K PF01504.18 CDI75853.1 - 0.04 13.1 13.3 0.049 12.9 13.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2126 PF09899.9 CDI75853.1 - 0.05 11.7 11.9 0.051 11.7 11.9 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Connexin PF00029.19 CDI75853.1 - 0.11 12.2 14.0 0.13 12.0 14.0 1.0 1 0 0 1 1 1 0 Connexin SpoIIP PF07454.11 CDI75853.1 - 0.15 11.5 18.0 0.16 11.4 18.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Band_3_cyto PF07565.13 CDI75853.1 - 0.17 11.6 15.4 0.18 11.6 15.4 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CDC45 PF02724.14 CDI75853.1 - 0.25 9.6 12.5 0.26 9.5 12.5 1.0 1 0 0 1 1 1 0 CDC45-like protein CPSF100_C PF13299.6 CDI75853.1 - 0.27 11.4 12.8 0.3 11.3 12.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal F-protein PF00469.20 CDI75853.1 - 0.29 10.7 13.0 0.3 10.7 13.0 1.0 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef CCDC53 PF10152.9 CDI75853.1 - 0.33 11.4 17.5 0.39 11.1 17.5 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF1764 PF08576.10 CDI75853.1 - 0.37 11.7 14.3 0.5 11.3 14.3 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Afi1 PF07792.12 CDI75853.1 - 0.5 10.8 15.0 0.58 10.7 15.0 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF3306 PF11748.8 CDI75853.1 - 0.51 11.2 13.8 0.65 10.9 13.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Kei1 PF08552.11 CDI75853.1 - 0.51 10.2 11.5 0.52 10.2 11.5 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 V_ATPase_I PF01496.19 CDI75853.1 - 0.54 8.1 19.4 0.5 8.2 19.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TRAP_alpha PF03896.16 CDI75853.1 - 0.56 9.4 7.9 0.58 9.3 7.9 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FAM60A PF15396.6 CDI75853.1 - 0.72 9.8 14.1 0.77 9.7 14.1 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF5308 PF17233.2 CDI75853.1 - 0.77 10.0 14.5 0.89 9.8 14.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) RP-C_C PF11800.8 CDI75853.1 - 0.8 9.8 13.8 0.78 9.8 13.8 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region Zip PF02535.22 CDI75853.1 - 0.95 8.6 12.2 1.1 8.5 12.2 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter UPF0560 PF10577.9 CDI75853.1 - 0.95 7.9 28.5 1 7.8 28.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DDHD PF02862.17 CDI75853.1 - 1 9.5 14.4 1.1 9.4 14.4 1.1 1 0 0 1 1 1 0 DDHD domain Pex14_N PF04695.13 CDI75853.1 - 1.5 9.5 25.8 1.5 9.5 25.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM76 PF16046.5 CDI75853.1 - 1.8 7.9 20.0 1.9 7.8 20.0 1.0 1 0 0 1 1 1 0 FAM76 protein Mlo PF03094.15 CDI75853.1 - 1.8 6.9 8.6 2 6.7 8.6 1.0 1 0 0 1 1 1 0 Mlo family Gti1_Pac2 PF09729.9 CDI75853.1 - 1.8 8.6 16.5 1.9 8.5 16.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family EIIBC-GUT_N PF03612.14 CDI75853.1 - 2.1 8.1 16.5 2.9 7.6 16.5 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CSG2 PF16965.5 CDI75853.1 - 2.1 7.2 10.9 2.1 7.2 10.9 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Histidinol_dh PF00815.20 CDI75853.1 - 2.4 7.1 9.7 2.6 6.9 9.7 1.0 1 0 0 1 1 1 0 Histidinol dehydrogenase DUF5523 PF17661.1 CDI75853.1 - 2.9 7.5 20.5 3 7.4 20.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Saw1 PF11561.8 CDI75853.1 - 2.9 7.4 12.4 3 7.3 12.4 1.1 1 0 0 1 1 1 0 Single strand annealing-weakened 1 DUF4746 PF15928.5 CDI75853.1 - 3 7.2 15.5 3.1 7.1 15.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Ureide_permease PF07168.11 CDI75853.1 - 3.3 6.4 9.1 3.4 6.3 9.1 1.1 1 0 0 1 1 1 0 Ureide permease DUF3984 PF13136.6 CDI75853.1 - 3.4 7.0 17.2 3.8 6.8 17.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) ALMT PF11744.8 CDI75853.1 - 3.6 6.3 15.4 3.6 6.3 15.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter OATP PF03137.20 CDI75853.1 - 3.7 5.7 9.3 3.9 5.7 9.3 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family PPL5 PF18168.1 CDI75853.1 - 3.9 6.7 14.8 3.9 6.7 14.8 1.0 1 0 0 1 1 1 0 Prim-pol family 5 Folliculin PF11704.8 CDI75853.1 - 4.4 7.2 16.5 5 7.0 16.5 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Sec62 PF03839.16 CDI75853.1 - 4.6 6.7 17.1 4.8 6.6 17.1 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2828 PF11443.8 CDI75853.1 - 4.8 5.1 18.4 4.7 5.2 18.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4638 PF15472.6 CDI75853.1 - 4.9 6.8 16.1 5 6.8 16.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) SelP_N PF04592.14 CDI75853.1 - 5 6.5 24.7 5.4 6.3 24.7 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RPN2_C PF18004.1 CDI75853.1 - 5.1 7.0 18.9 5.9 6.8 18.9 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pro_CA PF00484.19 CDI75853.1 - 5.4 7.3 14.4 7.2 6.9 0.1 2.1 2 0 0 2 2 2 0 Carbonic anhydrase NPR3 PF03666.13 CDI75853.1 - 6 5.5 17.9 6 5.5 17.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2370 PF10176.9 CDI75853.1 - 6.1 6.4 10.0 6.4 6.4 10.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) HNOBA PF07701.14 CDI75853.1 - 6.2 6.2 16.3 6.9 6.0 16.3 1.1 1 0 0 1 1 1 0 Heme NO binding associated RR_TM4-6 PF06459.12 CDI75853.1 - 6.4 6.5 22.1 6.9 6.4 22.1 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TERB2 PF15101.6 CDI75853.1 - 6.8 6.7 26.0 7.6 6.5 26.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Asparaginase_2 PF01112.18 CDI75853.1 - 7 5.6 10.6 7.5 5.5 10.6 1.1 1 0 0 1 1 1 0 Asparaginase Peptidase_U57 PF05582.12 CDI75853.1 - 7 5.8 14.9 7.8 5.7 14.9 1.1 1 0 0 1 1 1 0 YabG peptidase U57 DUF913 PF06025.12 CDI75853.1 - 7.1 5.5 12.6 6.9 5.5 12.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Neur_chan_memb PF02932.16 CDI75853.1 - 7.6 6.5 16.2 7.9 6.5 16.2 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Membralin PF09746.9 CDI75853.1 - 7.8 5.4 15.2 8.1 5.4 15.2 1.0 1 0 0 1 1 1 0 Tumour-associated protein Ctr PF04145.15 CDI75853.1 - 8.9 6.9 11.2 9.3 6.9 11.2 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Plasmodium_Vir PF05795.11 CDI75853.1 - 9.1 5.6 10.1 9.3 5.6 10.1 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Scs3p PF10261.9 CDI75853.1 - 9.5 5.6 8.0 10 5.5 8.0 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Otopetrin PF03189.13 CDI75853.1 - 9.6 4.9 12.0 9.5 4.9 12.0 1.0 1 0 0 1 1 1 0 Otopetrin HCO3_cotransp PF00955.21 CDI75853.1 - 10 4.8 9.2 10 4.8 9.2 1.0 1 0 0 1 1 1 0 HCO3- transporter family RskA PF10099.9 CDI75856.1 - 8e-06 26.3 7.7 8e-06 26.3 7.7 10.1 1 1 7 8 8 8 2 Anti-sigma-K factor rskA DUF4757 PF15949.5 CDI75856.1 - 0.46 10.9 0.0 0.46 10.9 0.0 7.0 3 3 4 7 7 7 0 Domain of unknown function (DUF4757) Transformer PF06495.11 CDI75857.1 - 0.023 14.8 22.4 0.027 14.6 22.4 1.2 1 0 0 1 1 1 0 Fruit fly transformer protein Presenilin PF01080.17 CDI75857.1 - 0.046 12.5 19.7 0.054 12.2 19.7 1.3 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI75857.1 - 0.43 9.5 16.5 0.52 9.3 16.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Asp-B-Hydro_N PF05279.11 CDI75857.1 - 0.67 10.0 22.9 0.81 9.7 22.9 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region O-antigen_lig PF13425.6 CDI75857.1 - 0.77 8.5 7.3 0.97 8.1 7.3 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CDC45 PF02724.14 CDI75857.1 - 0.85 7.8 31.1 1.2 7.4 31.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Mem_trans PF03547.18 CDI75857.1 - 1.4 7.2 5.5 2.3 6.5 5.5 1.5 1 0 0 1 1 1 0 Membrane transport protein SOBP PF15279.6 CDI75857.1 - 1.7 9.2 9.6 2.2 8.8 9.6 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein DUF2151 PF10221.9 CDI75857.1 - 2.7 6.5 15.5 3.3 6.2 15.5 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Hid1 PF12722.7 CDI75857.1 - 5.6 5.0 20.9 6.4 4.8 20.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Cupin_2 PF07883.11 CDI75858.1 - 0.00014 21.5 0.0 0.00029 20.5 0.0 1.5 1 0 0 1 1 1 1 Cupin domain SARAF PF06682.12 CDI75858.1 - 0.0079 15.9 16.7 0.0079 15.9 16.7 4.6 2 2 2 4 4 4 1 SOCE-associated regulatory factor of calcium homoeostasis Bestrophin PF01062.21 CDI75859.1 - 2.1 7.7 6.3 3.7 6.9 6.3 1.3 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel LMBR1 PF04791.16 CDI75859.1 - 3.7 6.3 4.5 5.3 5.8 4.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein NDUF_B6 PF09782.9 CDI75859.1 - 7.5 6.7 8.1 13 5.9 8.1 1.3 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit TFIIA PF03153.13 CDI75860.1 - 0.16 11.9 46.4 0.23 11.4 46.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PepSY_TM PF03929.16 CDI75860.1 - 0.31 10.7 2.3 0.3 10.7 2.3 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Ebp2 PF05890.12 CDI75860.1 - 1.8 8.1 21.7 2.2 7.7 21.7 1.1 1 0 0 1 1 1 0 Eukaryotic rRNA processing protein EBP2 DivIC PF04977.15 CDI75860.1 - 2.9 7.7 12.9 6.4 6.6 12.9 1.5 1 0 0 1 1 1 0 Septum formation initiator BUD22 PF09073.10 CDI75860.1 - 3.2 7.0 35.9 3.8 6.8 35.9 1.0 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 CDI75861.1 - 2.5 6.2 28.2 3 5.9 28.2 1.0 1 0 0 1 1 1 0 Nop14-like family Sin_N PF04801.13 CDI75861.1 - 5.7 6.1 36.2 7.8 5.6 36.2 1.3 1 0 0 1 1 1 0 Sin-like protein conserved region Pet20 PF08692.10 CDI75862.1 - 1.3 9.7 0.0 1.3 9.7 0.0 5.1 3 2 2 5 5 5 0 Mitochondrial protein Pet20 TERB2 PF15101.6 CDI75864.1 - 0.0094 16.0 12.9 0.0094 16.0 12.9 8.9 2 2 6 8 8 8 1 Telomere-associated protein TERB2 HEV_ORF1 PF02444.16 CDI75864.1 - 7.9 7.1 6.5 4.3 7.9 2.4 2.4 2 0 0 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) GYF PF02213.16 CDI75866.1 - 3.9e-09 36.0 0.0 9.1e-09 34.9 0.0 1.6 1 0 0 1 1 1 1 GYF domain CPSase_L_D2 PF02786.17 CDI75867.1 - 6.2e-19 68.3 0.2 8e-19 68.0 0.2 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain BAF1_ABF1 PF04684.13 CDI75867.1 - 0.0025 17.0 3.6 0.0026 16.9 3.6 1.0 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor ATP-grasp_5 PF13549.6 CDI75867.1 - 0.01 15.3 0.1 0.013 14.9 0.1 1.1 1 0 0 1 1 1 0 ATP-grasp domain Secretin_N_2 PF07655.13 CDI75867.1 - 0.01 16.3 22.7 0.015 15.8 22.7 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Menin PF05053.13 CDI75867.1 - 0.014 13.8 6.6 0.018 13.4 6.6 1.2 1 0 0 1 1 1 0 Menin Macoilin PF09726.9 CDI75867.1 - 0.026 13.1 7.3 0.024 13.2 7.3 1.2 1 0 0 1 1 1 0 Macoilin family Sporozoite_P67 PF05642.11 CDI75867.1 - 0.045 11.8 3.6 0.049 11.7 3.6 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ATP-grasp PF02222.22 CDI75867.1 - 0.052 13.1 0.0 0.069 12.7 0.0 1.2 1 0 0 1 1 1 0 ATP-grasp domain POX PF07526.11 CDI75867.1 - 1.1 9.8 5.9 1.5 9.4 5.9 1.3 1 0 0 1 1 1 0 Associated with HOX Presenilin PF01080.17 CDI75867.1 - 2.5 6.8 6.3 2.6 6.7 6.3 1.1 1 0 0 1 1 1 0 Presenilin Orf78 PF06024.12 CDI75867.1 - 4.1 7.7 5.8 7.5 6.9 5.8 1.4 1 0 0 1 1 1 0 Orf78 (ac78) CCDC106 PF15794.5 CDI75867.1 - 7.7 6.2 10.1 8.8 6.0 10.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 RRM_3 PF08777.11 CDI75868.1 - 0.0075 16.3 0.6 0.0075 16.3 0.6 2.1 1 1 1 2 2 1 1 RNA binding motif SNAP PF14938.6 CDI75868.1 - 0.023 14.1 14.8 0.034 13.6 14.8 1.4 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP SelP_N PF04592.14 CDI75868.1 - 0.11 11.9 19.5 0.12 11.8 19.5 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region NicO PF03824.16 CDI75868.1 - 0.12 11.7 4.0 0.13 11.5 4.0 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein CSG2 PF16965.5 CDI75868.1 - 0.37 9.7 9.7 0.4 9.6 9.7 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2052 PF09747.9 CDI75868.1 - 0.37 10.9 21.1 0.4 10.8 21.1 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SLC12 PF03522.15 CDI75868.1 - 0.61 9.0 18.2 0.69 8.9 18.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF2828 PF11443.8 CDI75868.1 - 0.68 7.9 17.7 0.69 7.9 17.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Neur_chan_memb PF02932.16 CDI75868.1 - 1.1 9.3 13.0 1.1 9.3 13.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RskA PF10099.9 CDI75868.1 - 1.5 9.1 17.4 0.3 11.4 10.3 2.0 1 1 1 2 2 1 0 Anti-sigma-K factor rskA Serinc PF03348.15 CDI75868.1 - 1.8 7.4 10.1 1.8 7.4 10.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Presenilin PF01080.17 CDI75868.1 - 1.8 7.2 19.1 1.9 7.2 19.1 1.1 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 CDI75868.1 - 2 6.2 20.8 2.1 6.2 20.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-3_zeta PF05091.12 CDI75868.1 - 2 7.3 18.8 2.1 7.3 18.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Gti1_Pac2 PF09729.9 CDI75868.1 - 2 8.4 12.0 2 8.4 12.0 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Pex14_N PF04695.13 CDI75868.1 - 3.9 8.1 23.8 4.9 7.8 23.8 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SID-1_RNA_chan PF13965.6 CDI75868.1 - 4.2 5.6 7.9 4.4 5.6 7.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 YABBY PF04690.13 CDI75868.1 - 4.8 7.7 15.6 5.3 7.6 15.6 1.2 1 0 0 1 1 1 0 YABBY protein EOS1 PF12326.8 CDI75868.1 - 5.6 6.9 8.6 5.9 6.8 8.6 1.2 1 0 0 1 1 1 0 N-glycosylation protein Scs3p PF10261.9 CDI75868.1 - 5.9 6.3 7.5 6.6 6.2 7.5 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DDHD PF02862.17 CDI75868.1 - 6.3 6.9 14.4 7.6 6.6 14.4 1.2 1 0 0 1 1 1 0 DDHD domain FAM60A PF15396.6 CDI75868.1 - 7 6.6 13.2 7.3 6.5 13.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A CLN3 PF02487.17 CDI75868.1 - 7 5.6 15.8 7.7 5.4 15.8 1.0 1 0 0 1 1 1 0 CLN3 protein Nucleoside_tran PF01733.18 CDI75868.1 - 7.1 5.9 5.3 8.2 5.7 5.3 1.1 1 0 0 1 1 1 0 Nucleoside transporter RskA PF10099.9 CDI75872.1 - 2.1e-06 28.2 8.6 0.00016 22.0 0.0 14.1 5 3 6 11 11 11 4 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI75872.1 - 9.2e-06 24.9 10.8 9.2e-06 24.9 10.8 13.7 7 3 4 12 12 12 2 Protein of unknown function (DUF2722) Activator_LAG-3 PF11498.8 CDI75872.1 - 0.0018 17.3 20.1 0.0018 17.3 20.1 10.8 10 1 1 11 11 11 3 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI75872.1 - 0.0055 16.3 10.5 0.0055 16.3 10.5 13.2 9 3 4 13 13 13 5 Spt20 family Ribosomal_60s PF00428.19 CDI75872.1 - 0.0087 16.6 5.7 0.0087 16.6 5.7 14.3 12 1 0 12 12 12 3 60s Acidic ribosomal protein Cation_ATPase PF13246.6 CDI75872.1 - 0.16 12.1 1.3 6 7.0 1.3 3.7 1 1 0 1 1 1 0 Cation transport ATPase (P-type) RCR PF12273.8 CDI75873.1 - 0.72 10.5 0.1 0.72 10.5 0.1 6.9 2 1 1 3 3 3 0 Chitin synthesis regulation, resistance to Congo red Pkinase PF00069.25 CDI75874.1 - 0.0031 16.9 8.6 0.041 13.2 0.0 3.5 4 0 0 4 4 4 2 Protein kinase domain RIFIN PF02009.16 CDI75874.1 - 0.013 15.4 1.3 0.013 15.4 1.3 4.8 3 1 0 4 4 4 0 Rifin RskA PF10099.9 CDI75874.1 - 0.082 13.2 0.2 0.082 13.2 0.2 7.2 4 2 1 5 5 5 0 Anti-sigma-K factor rskA SRP-alpha_N PF04086.13 CDI75874.1 - 0.19 11.6 0.0 0.19 11.6 0.0 3.8 3 2 0 4 4 4 0 Signal recognition particle, alpha subunit, N-terminal RskA PF10099.9 CDI75875.1 - 8.5e-05 22.9 15.7 0.002 18.4 7.6 8.9 3 3 2 6 6 6 2 Anti-sigma-K factor rskA TAF4 PF05236.14 CDI75875.1 - 0.0014 18.5 10.8 0.0014 18.5 10.8 5.8 3 2 0 4 4 4 1 Transcription initiation factor TFIID component TAF4 family Sporozoite_P67 PF05642.11 CDI75875.1 - 0.0014 16.8 8.8 0.0014 16.8 8.8 4.9 3 1 0 4 4 4 1 Sporozoite P67 surface antigen AF-4 PF05110.13 CDI75876.1 - 0.042 11.9 22.0 0.041 12.0 22.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TipE PF16972.5 CDI75876.1 - 2.9 6.9 11.0 3.4 6.8 11.0 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE PTPRCAP PF15713.5 CDI75878.1 - 4.2e-05 23.9 48.4 0.072 13.4 10.2 3.1 3 0 0 3 3 3 3 Protein tyrosine phosphatase receptor type C-associated Pex14_N PF04695.13 CDI75878.1 - 0.00028 21.6 55.0 0.07 13.8 14.4 3.1 3 0 0 3 3 3 3 Peroxisomal membrane anchor protein (Pex14p) conserved region SpoIIP PF07454.11 CDI75878.1 - 0.0017 17.9 42.2 0.025 14.0 11.0 3.1 3 0 0 3 3 3 2 Stage II sporulation protein P (SpoIIP) BORG_CEP PF14957.6 CDI75878.1 - 0.0027 18.9 25.9 0.67 11.1 4.5 3.1 3 0 0 3 3 3 2 Cdc42 effector RPA43_OB PF17875.1 CDI75878.1 - 0.0028 18.3 29.7 0.034 14.8 4.1 3.2 3 0 0 3 3 3 1 RPA43 OB domain in RNA Pol I AP3D1 PF06375.11 CDI75878.1 - 0.0045 17.2 5.0 0.0045 17.2 5.0 3.1 3 0 0 3 3 3 1 AP-3 complex subunit delta-1 GEMIN8 PF15348.6 CDI75878.1 - 0.0058 17.0 11.7 0.0058 17.0 11.7 3.1 3 0 0 3 3 3 1 Gemini of Cajal bodies-associated protein 8 Peptidase_S49_N PF08496.10 CDI75878.1 - 0.0061 16.6 35.1 0.032 14.3 8.0 3.2 3 0 0 3 3 3 2 Peptidase family S49 N-terminal EIIBC-GUT_N PF03612.14 CDI75878.1 - 0.0066 16.2 35.6 0.29 10.9 8.7 3.1 3 0 0 3 3 3 3 Sorbitol phosphotransferase enzyme II N-terminus DUF719 PF05334.13 CDI75878.1 - 0.0085 16.3 32.3 0.38 10.9 6.6 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF719) RR_TM4-6 PF06459.12 CDI75878.1 - 0.0098 15.7 7.6 0.0098 15.7 7.6 3.0 3 0 0 3 3 3 1 Ryanodine Receptor TM 4-6 FAM76 PF16046.5 CDI75878.1 - 0.011 15.1 40.2 0.067 12.5 7.4 3.1 3 0 0 3 3 3 0 FAM76 protein FAM60A PF15396.6 CDI75878.1 - 0.013 15.5 26.3 0.16 11.9 6.2 3.0 3 0 0 3 3 3 0 Protein Family FAM60A Connexin PF00029.19 CDI75878.1 - 0.017 14.9 33.3 0.54 10.0 8.5 3.1 3 0 0 3 3 3 0 Connexin DUF3807 PF12720.7 CDI75878.1 - 0.017 15.4 51.6 0.15 12.3 14.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) DUF4159 PF13709.6 CDI75878.1 - 0.018 14.5 1.1 0.018 14.5 1.1 2.2 3 0 0 3 3 2 0 Domain of unknown function (DUF4159) ANAPC_CDC26 PF10471.9 CDI75878.1 - 0.036 14.9 9.9 0.036 14.9 9.9 5.0 3 2 1 4 4 1 0 Anaphase-promoting complex APC subunit CDC26 MRNIP PF15749.5 CDI75878.1 - 0.041 14.6 49.1 0.84 10.4 3.9 3.2 3 0 0 3 3 3 0 MRN-interacting protein DUF4834 PF16118.5 CDI75878.1 - 0.042 14.8 49.6 1.1 10.2 14.8 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) CNDH2_C PF16858.5 CDI75878.1 - 0.075 12.9 44.2 0.096 12.5 12.1 3.0 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term AIF_C PF14721.6 CDI75878.1 - 0.08 13.3 35.1 1.6 9.1 10.1 3.3 3 0 0 3 3 3 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TCP PF03634.13 CDI75878.1 - 0.084 13.4 38.0 0.27 11.8 5.7 3.2 3 0 0 3 3 3 0 TCP family transcription factor CSRNP_N PF16019.5 CDI75878.1 - 0.15 12.0 36.6 0.02 14.8 7.2 3.2 3 0 0 3 3 3 0 Cysteine/serine-rich nuclear protein N-terminus DUF5327 PF17261.2 CDI75878.1 - 0.18 12.6 56.6 1.1 10.0 19.7 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5327) DUF5523 PF17661.1 CDI75878.1 - 0.19 11.4 48.9 0.091 12.4 12.1 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5523) Utp14 PF04615.13 CDI75878.1 - 0.2 10.2 37.2 0.44 9.1 37.2 1.5 1 1 0 1 1 1 0 Utp14 protein RXT2_N PF08595.11 CDI75878.1 - 0.21 11.6 32.4 0.1 12.6 7.6 3.1 3 0 0 3 3 3 0 RXT2-like, N-terminal BSP_II PF05432.11 CDI75878.1 - 0.24 11.1 25.4 0.059 13.1 2.6 3.1 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) 2-Hacid_dh_C PF02826.19 CDI75878.1 - 0.26 10.6 0.1 0.26 10.6 0.1 3.2 3 1 0 3 3 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MMR1 PF08505.10 CDI75878.1 - 0.27 11.5 56.0 0.29 11.4 13.0 3.0 3 0 0 3 3 3 0 Mitochondrial Myo2 receptor-related protein DUF4366 PF14283.6 CDI75878.1 - 0.32 11.0 28.3 1.1 9.3 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4366) PAXIP1_C PF15364.6 CDI75878.1 - 0.37 11.1 0.1 0.37 11.1 0.1 3.4 2 1 1 3 3 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein CobT PF06213.12 CDI75878.1 - 0.38 10.1 68.4 0.27 10.6 18.0 3.1 3 0 0 3 3 3 0 Cobalamin biosynthesis protein CobT PRP1_N PF06424.12 CDI75878.1 - 0.48 10.8 41.4 1.9 8.9 13.9 3.1 3 0 0 3 3 3 0 PRP1 splicing factor, N-terminal DUF3464 PF11947.8 CDI75878.1 - 0.6 9.8 43.0 0.77 9.5 0.4 3.4 3 0 0 3 3 3 0 Photosynthesis affected mutant 68 Thg1C PF14413.6 CDI75878.1 - 0.67 10.1 31.6 0.41 10.8 4.6 3.7 3 0 0 3 3 3 0 Thg1 C terminal domain DUF4666 PF15697.5 CDI75878.1 - 0.68 10.6 32.0 0.57 10.9 6.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4666) DUF4484 PF14831.6 CDI75878.1 - 0.74 9.8 30.5 2.6 8.0 6.7 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4484) Ferlin_C PF16165.5 CDI75878.1 - 0.92 9.4 14.2 11 5.9 1.7 3.2 3 0 0 3 3 3 0 Ferlin C-terminus Rxt3 PF08642.10 CDI75878.1 - 1.1 10.1 27.5 5.7 7.7 6.8 3.3 3 0 0 3 3 3 0 Histone deacetylation protein Rxt3 SIN1 PF05422.12 CDI75878.1 - 1.1 9.8 38.5 0.57 10.7 11.4 3.2 3 0 0 3 3 3 0 Stress-activated map kinase interacting protein 1 (SIN1) Pox_Ag35 PF03286.14 CDI75878.1 - 1.2 8.9 31.5 0.53 10.1 5.2 3.1 3 0 0 3 3 3 0 Pox virus Ag35 surface protein PRC2_HTH_1 PF18118.1 CDI75878.1 - 1.2 10.0 34.7 5 8.0 0.7 3.2 3 0 0 3 3 3 0 Polycomb repressive complex 2 tri-helical domain Mak16 PF04874.14 CDI75878.1 - 1.4 9.6 38.8 7.5 7.2 9.7 3.3 3 0 0 3 3 3 0 Mak16 protein C-terminal region DUF4770 PF15994.5 CDI75878.1 - 1.6 9.0 50.8 3.9 7.7 4.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4770) PPL5 PF18168.1 CDI75878.1 - 1.8 7.8 32.2 0.18 11.1 8.0 3.1 3 0 0 3 3 3 0 Prim-pol family 5 Slu7 PF11708.8 CDI75878.1 - 2 8.1 51.5 1.4 8.6 1.3 3.1 3 0 0 3 3 3 0 Pre-mRNA splicing Prp18-interacting factor V_ATPase_I PF01496.19 CDI75878.1 - 2.1 6.1 44.4 0.73 7.7 10.5 3.0 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 CDI75878.1 - 2.6 6.3 35.9 1 7.6 7.5 3.0 3 0 0 3 3 3 0 CDC45-like protein F-protein PF00469.20 CDI75878.1 - 3 7.4 39.1 0.099 12.2 12.0 3.1 3 0 0 3 3 3 0 Negative factor, (F-Protein) or Nef DUF4746 PF15928.5 CDI75878.1 - 3 7.2 40.8 0.43 10.0 9.7 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4746) MMU163 PF17119.5 CDI75878.1 - 3.2 6.9 22.3 2.8 7.0 3.7 3.1 3 0 0 3 3 3 0 Mitochondrial protein up-regulated during meiosis DUF3408 PF11888.8 CDI75878.1 - 3.4 7.8 49.0 5.7 7.1 15.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3408) Mlh1_C PF16413.5 CDI75878.1 - 3.7 6.8 31.5 0.57 9.5 4.8 3.3 3 0 0 3 3 3 0 DNA mismatch repair protein Mlh1 C-terminus TraV PF09676.10 CDI75878.1 - 4 8.4 38.0 2 9.4 7.8 3.3 3 0 0 3 3 3 0 Type IV conjugative transfer system lipoprotein (TraV) MPM1 PF17234.2 CDI75878.1 - 4.1 7.6 50.0 2.1 8.6 10.7 3.1 3 0 0 3 3 3 0 Mitochondrial peculiar membrane protein 1 Peroxin-13_N PF04088.13 CDI75878.1 - 4.5 7.5 27.3 2.3 8.5 5.3 3.2 3 0 0 3 3 3 0 Peroxin 13, N-terminal region STAC2_u1 PF16664.5 CDI75878.1 - 6.5 7.2 32.1 3.6 8.1 4.3 3.3 3 0 0 3 3 3 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 ARF7EP_C PF14949.6 CDI75878.1 - 6.6 7.4 35.9 0.7 10.5 8.3 3.4 3 0 0 3 3 3 0 ARF7 effector protein C-terminus Serinc PF03348.15 CDI75878.1 - 7.3 5.4 28.9 1.9 7.3 4.2 3.0 3 0 0 3 3 3 0 Serine incorporator (Serinc) GOLD_2 PF13897.6 CDI75878.1 - 7.9 7.0 16.7 15 6.1 1.9 3.3 3 0 0 3 3 3 0 Golgi-dynamics membrane-trafficking RMP PF14996.6 CDI75878.1 - 7.9 6.7 32.4 3.6 7.8 0.4 3.2 3 0 0 3 3 3 0 Retinal Maintenance U1snRNP70_N PF12220.8 CDI75878.1 - 9.8 6.9 42.9 10 6.8 5.0 3.5 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Trypan_PARP PF05887.11 CDI75879.1 - 1.6e-05 24.9 6.9 1.6e-05 24.9 6.9 4.4 2 2 1 3 3 3 1 Procyclic acidic repetitive protein (PARP) SelP_N PF04592.14 CDI75880.1 - 0.59 9.5 32.1 0.62 9.4 32.1 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PTPRCAP PF15713.5 CDI75880.1 - 9.6 6.5 27.2 10 6.4 27.2 1.0 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Suppressor_APC PF11414.8 CDI75881.1 - 0.0052 16.8 3.4 0.0071 16.4 3.4 1.2 1 0 0 1 1 1 1 Adenomatous polyposis coli tumour suppressor protein YbfN PF13982.6 CDI75881.1 - 0.0064 16.7 0.7 0.025 14.8 0.0 2.0 1 1 1 2 2 2 1 YbfN-like lipoprotein Arc_C PF18162.1 CDI75881.1 - 0.033 14.0 0.1 0.054 13.4 0.1 1.4 1 1 0 1 1 1 0 Arc C-lobe COX16 PF14138.6 CDI75881.1 - 0.043 14.3 0.9 0.068 13.7 0.9 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 PqqD PF05402.12 CDI75881.1 - 0.045 14.0 0.9 0.063 13.6 0.1 1.6 2 0 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) Rootletin PF15035.6 CDI75881.1 - 0.052 13.6 6.3 0.058 13.4 6.3 1.0 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion CRIC_ras_sig PF10534.9 CDI75881.1 - 0.057 13.6 1.2 0.19 11.9 0.3 1.9 1 1 1 2 2 2 0 Connector enhancer of kinase suppressor of ras Nup88 PF10168.9 CDI75881.1 - 0.15 9.9 8.2 0.16 9.8 8.2 1.0 1 0 0 1 1 1 0 Nuclear pore component DUF4200 PF13863.6 CDI75881.1 - 0.2 12.1 11.7 0.35 11.3 11.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) APG6_N PF17675.1 CDI75881.1 - 0.2 12.2 12.6 0.27 11.7 11.8 1.6 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF1664 PF07889.12 CDI75881.1 - 0.21 11.7 3.0 0.28 11.2 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 CDI75881.1 - 0.25 11.4 8.9 0.29 11.2 8.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CorA PF01544.18 CDI75881.1 - 0.35 10.1 3.1 0.41 9.9 3.1 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein TMPIT PF07851.13 CDI75881.1 - 0.74 9.0 4.3 0.85 8.8 4.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF1104 PF06518.11 CDI75882.1 - 0.15 12.4 2.5 0.19 12.1 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) Sin_N PF04801.13 CDI75883.1 - 0.27 10.4 33.7 0.093 11.9 5.0 2.6 2 0 0 2 2 2 0 Sin-like protein conserved region DUF1645 PF07816.11 CDI75884.1 - 0.075 13.6 3.2 0.19 12.3 3.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) EOS1 PF12326.8 CDI75884.1 - 0.53 10.2 9.0 0.46 10.4 6.5 2.1 1 1 0 1 1 1 0 N-glycosylation protein SRP9-21 PF05486.12 CDI75884.1 - 1.1 9.7 7.1 22 5.5 0.0 3.1 3 0 0 3 3 3 0 Signal recognition particle 9 kDa protein (SRP9) Hep_59 PF07052.11 CDI75884.1 - 1.1 10.0 15.4 2.9 8.7 2.0 3.1 3 0 0 3 3 3 0 Hepatocellular carcinoma-associated antigen 59 DUF3854 PF12965.7 CDI75884.1 - 1.8 8.6 5.9 0.54 10.2 2.5 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3854) TFIIA PF03153.13 CDI75884.1 - 3.8 7.4 48.4 23 4.8 48.4 1.9 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Chorein_N PF12624.7 CDI75884.1 - 7.1 6.8 14.7 0.26 11.4 5.5 2.8 3 0 0 3 3 3 0 N-terminal region of Chorein or VPS13 MMR1 PF08505.10 CDI75885.1 - 0.067 13.5 49.2 0.27 11.5 23.2 2.3 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Presenilin PF01080.17 CDI75885.1 - 0.27 9.9 46.4 0.22 10.3 14.4 2.2 2 0 0 2 2 2 0 Presenilin DUF4746 PF15928.5 CDI75885.1 - 1.3 8.4 20.8 1.1 8.6 4.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) V_ATPase_I PF01496.19 CDI75885.1 - 1.5 6.6 38.2 0.046 11.6 10.2 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family SRP-alpha_N PF04086.13 CDI75885.1 - 3.9 7.3 40.4 4.7 7.0 20.9 2.2 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Neur_chan_memb PF02932.16 CDI75885.1 - 4.1 7.4 34.6 1.7 8.7 9.4 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF2052 PF09747.9 CDI75885.1 - 4.3 7.4 35.1 3.7 7.6 9.8 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Raftlin PF15250.6 CDI75885.1 - 4.4 5.9 37.1 0.11 11.2 9.2 2.1 2 0 0 2 2 2 0 Raftlin Vfa1 PF08432.10 CDI75885.1 - 4.6 7.5 40.1 2.5 8.4 9.1 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 GET2 PF08690.10 CDI75885.1 - 4.6 6.8 39.5 2.4 7.7 20.1 2.3 2 0 0 2 2 2 0 GET complex subunit GET2 DUF4647 PF15504.6 CDI75885.1 - 4.7 6.2 38.6 0.23 10.6 19.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) CCSAP PF15748.5 CDI75885.1 - 5.6 7.1 48.9 0.92 9.6 12.2 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Draxin PF15550.6 CDI75885.1 - 5.7 6.7 31.2 5.4 6.8 5.1 2.2 2 0 0 2 2 2 0 Draxin FAM60A PF15396.6 CDI75885.1 - 7.5 6.5 37.4 1.1 9.2 8.8 2.2 2 0 0 2 2 2 0 Protein Family FAM60A GCOM2 PF15328.6 CDI75885.1 - 8 6.8 41.0 0.21 11.9 10.4 2.3 2 0 0 2 2 2 0 Putative GRINL1B complex locus protein 2 SUIM_assoc PF16619.5 CDI75886.1 - 0.0018 18.3 4.6 0.0018 18.3 4.6 13.7 8 3 3 11 11 11 2 Unstructured region C-term to UIM in Ataxin3 BAF1_ABF1 PF04684.13 CDI75887.1 - 0.13 11.2 20.3 0.16 11.0 20.3 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4407 PF14362.6 CDI75887.1 - 1.7 7.9 19.5 1.8 7.8 19.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) eIF-3_zeta PF05091.12 CDI75887.1 - 4 6.3 21.2 5.2 5.9 21.2 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) UCR_Fe-S_N PF10399.9 CDI75887.1 - 6.2 6.3 10.1 15 5.0 10.1 1.6 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal BUD22 PF09073.10 CDI75888.1 - 0.07 12.5 43.1 0.095 12.0 43.1 1.1 1 0 0 1 1 1 0 BUD22 SSP160 PF06933.11 CDI75888.1 - 0.26 9.4 22.6 0.31 9.2 22.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF572 PF04502.13 CDI75888.1 - 0.29 10.7 36.0 0.41 10.2 36.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) MMR1 PF08505.10 CDI75888.1 - 1.1 9.5 39.8 1.8 8.8 39.8 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Macoilin PF09726.9 CDI75888.1 - 1.5 7.3 43.0 1.9 6.9 43.0 1.1 1 0 0 1 1 1 0 Macoilin family Nop14 PF04147.12 CDI75888.1 - 7.2 4.7 36.0 10 4.2 36.0 1.3 1 0 0 1 1 1 0 Nop14-like family Mitofilin PF09731.9 CDI75888.1 - 8.4 5.1 45.7 11 4.8 45.7 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein AF-4 PF05110.13 CDI75889.1 - 0.57 8.2 72.9 0.86 7.6 72.9 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Utp14 PF04615.13 CDI75889.1 - 3.2 6.2 70.8 3.9 5.9 70.8 1.0 1 0 0 1 1 1 0 Utp14 protein SR-25 PF10500.9 CDI75890.1 - 0.00042 20.0 16.6 0.00057 19.6 16.6 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF2828 PF11443.8 CDI75890.1 - 0.0099 14.0 7.5 0.011 13.8 7.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) Med3 PF11593.8 CDI75890.1 - 0.037 13.2 24.9 0.043 13.0 3.4 2.2 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Opi1 PF08618.10 CDI75890.1 - 0.087 12.1 13.3 0.099 11.9 13.3 1.1 1 0 0 1 1 1 0 Transcription factor Opi1 RLL PF10036.9 CDI75890.1 - 0.1 12.4 14.4 1.7 8.4 8.4 2.2 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein SLC12 PF03522.15 CDI75890.1 - 0.11 11.4 15.0 0.13 11.2 15.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Ndc1_Nup PF09531.10 CDI75890.1 - 0.16 10.6 18.2 0.2 10.3 18.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup U1snRNP70_N PF12220.8 CDI75890.1 - 0.2 12.3 9.3 3.6 8.3 3.3 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Orf78 PF06024.12 CDI75890.1 - 0.21 11.9 8.8 1.8 8.9 0.4 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Hid1 PF12722.7 CDI75890.1 - 0.24 9.5 16.9 0.26 9.4 16.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ferlin_C PF16165.5 CDI75890.1 - 0.32 10.9 4.7 2.2 8.2 1.5 2.1 2 0 0 2 2 2 0 Ferlin C-terminus Coilin_N PF15862.5 CDI75890.1 - 0.32 10.8 21.5 0.12 12.2 9.0 2.2 2 0 0 2 2 2 0 Coilin N-terminus K_channel_TID PF07941.11 CDI75890.1 - 0.49 10.9 0.2 0.49 10.9 0.2 3.0 3 1 0 3 3 1 0 Potassium channel Kv1.4 tandem inactivation domain eIF_4EBP PF05456.11 CDI75890.1 - 0.89 9.5 15.2 0.77 9.7 1.0 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Presenilin PF01080.17 CDI75890.1 - 1.8 7.2 20.0 2.3 6.9 20.0 1.1 1 0 0 1 1 1 0 Presenilin DUF2681 PF10883.8 CDI75890.1 - 2 8.9 23.2 0.64 10.5 1.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Peroxin-13_N PF04088.13 CDI75890.1 - 2.1 8.6 8.3 11 6.3 3.0 2.2 2 0 0 2 2 2 0 Peroxin 13, N-terminal region O-antigen_lig PF13425.6 CDI75890.1 - 2.6 6.8 4.4 3.1 6.5 4.4 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RAB3GAP2_N PF14655.6 CDI75890.1 - 3.2 6.9 14.5 3.3 6.9 5.4 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF3408 PF11888.8 CDI75890.1 - 3.3 7.8 16.4 3.7 7.7 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) tRNA_synt_1c_R2 PF04557.15 CDI75890.1 - 5.8 7.9 13.3 16 6.5 0.9 2.2 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 XRN_M PF17846.1 CDI75890.1 - 6.8 5.5 12.5 8.6 5.2 12.5 1.1 1 0 0 1 1 1 0 Xrn1 helical domain ALMT PF11744.8 CDI75890.1 - 7.1 5.3 10.1 9.7 4.9 10.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter RskA PF10099.9 CDI75890.1 - 9.2 6.5 21.2 1.6e+04 -4.0 21.2 2.1 1 1 0 1 1 0 0 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI75891.1 - 0.02 14.5 41.0 0.026 14.2 41.0 1.1 1 0 0 1 1 1 0 Spt20 family RPN2_C PF18004.1 CDI75891.1 - 0.16 11.8 14.4 0.16 11.8 14.4 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain SUFU_C PF12470.8 CDI75891.1 - 0.27 11.2 14.4 0.3 11.1 14.4 1.0 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain Sec62 PF03839.16 CDI75891.1 - 0.46 9.9 15.1 0.48 9.9 15.1 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 CPSF100_C PF13299.6 CDI75891.1 - 0.85 9.8 16.2 1 9.5 16.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal TFIIA PF03153.13 CDI75891.1 - 0.88 9.5 38.8 0.92 9.4 38.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TERB2 PF15101.6 CDI75891.1 - 0.97 9.4 23.5 1.1 9.3 23.5 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DDHD PF02862.17 CDI75891.1 - 1 9.5 15.1 1.1 9.3 15.1 1.1 1 0 0 1 1 1 0 DDHD domain HemX PF04375.14 CDI75891.1 - 1.3 8.3 29.8 1.4 8.1 29.8 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase CSRNP_N PF16019.5 CDI75891.1 - 1.3 8.9 17.3 1.4 8.8 17.3 1.0 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus FAM176 PF14851.6 CDI75891.1 - 1.5 8.5 13.1 1.7 8.3 13.1 1.2 1 0 0 1 1 1 0 FAM176 family DUF702 PF05142.12 CDI75891.1 - 1.7 9.1 16.5 2.1 8.8 16.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Presenilin PF01080.17 CDI75891.1 - 1.7 7.3 22.9 1.9 7.2 22.9 1.0 1 0 0 1 1 1 0 Presenilin FHIPEP PF00771.20 CDI75891.1 - 1.8 6.9 12.3 1.8 7.0 12.3 1.0 1 0 0 1 1 1 0 FHIPEP family Connexin PF00029.19 CDI75891.1 - 1.9 8.2 14.5 2 8.1 14.5 1.1 1 0 0 1 1 1 0 Connexin Pannexin_like PF12534.8 CDI75891.1 - 2.3 7.2 13.7 2.4 7.1 13.7 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 EIIBC-GUT_N PF03612.14 CDI75891.1 - 2.8 7.6 16.7 3.1 7.5 16.7 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Pex14_N PF04695.13 CDI75891.1 - 2.9 8.5 26.5 3.5 8.3 26.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM60A PF15396.6 CDI75891.1 - 3.2 7.7 13.6 3.8 7.5 13.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF2370 PF10176.9 CDI75891.1 - 3.2 7.3 9.0 2.9 7.5 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) FAM91_C PF14648.6 CDI75891.1 - 3.3 6.4 10.2 3.4 6.4 10.2 1.1 1 0 0 1 1 1 0 FAM91 C-terminus EPL1 PF10513.9 CDI75891.1 - 3.7 7.9 20.7 4.9 7.5 20.7 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF4746 PF15928.5 CDI75891.1 - 3.8 6.8 17.5 4.2 6.7 17.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF1764 PF08576.10 CDI75891.1 - 4 8.4 16.0 5.5 7.9 16.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) HNOBA PF07701.14 CDI75891.1 - 4.1 6.8 14.8 4.2 6.7 14.8 1.1 1 0 0 1 1 1 0 Heme NO binding associated GNAT_acetyltr_2 PF13718.6 CDI75891.1 - 4.1 6.7 13.1 4.7 6.5 13.1 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 CLN3 PF02487.17 CDI75891.1 - 4.2 6.3 15.3 4.7 6.2 15.3 1.0 1 0 0 1 1 1 0 CLN3 protein CCDC53 PF10152.9 CDI75891.1 - 4.2 7.8 19.7 4.9 7.5 19.7 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex TRAP_alpha PF03896.16 CDI75891.1 - 4.3 6.4 11.1 4.4 6.4 11.1 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit ALMT PF11744.8 CDI75891.1 - 4.4 6.0 16.4 4.5 6.0 16.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter GOLD_2 PF13897.6 CDI75891.1 - 4.4 7.8 6.6 5.4 7.5 6.6 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Peptidase_U57 PF05582.12 CDI75891.1 - 4.6 6.4 11.2 4.8 6.3 11.2 1.2 1 0 0 1 1 1 0 YabG peptidase U57 DUF4392 PF14336.6 CDI75891.1 - 4.7 6.6 5.6 5.1 6.4 5.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) Ureide_permease PF07168.11 CDI75891.1 - 4.8 5.8 9.1 4.7 5.9 9.1 1.1 1 0 0 1 1 1 0 Ureide permease DUF2828 PF11443.8 CDI75891.1 - 5.2 5.0 17.8 5.4 5.0 17.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Endostatin PF06482.11 CDI75891.1 - 5.3 6.4 18.8 5.6 6.3 18.8 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin GREB1 PF15782.5 CDI75891.1 - 5.4 4.0 17.3 5.8 3.9 17.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PTPRCAP PF15713.5 CDI75891.1 - 5.4 7.3 24.0 6 7.1 24.0 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SLC12 PF03522.15 CDI75891.1 - 5.4 5.9 19.8 6.2 5.7 19.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF3464 PF11947.8 CDI75891.1 - 5.9 6.6 16.6 7.7 6.2 16.6 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 SpoIIP PF07454.11 CDI75891.1 - 6.1 6.2 22.3 7.4 5.9 22.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Paramyxo_ncap PF00973.19 CDI75891.1 - 6.1 5.6 14.2 6.5 5.6 14.2 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF5308 PF17233.2 CDI75891.1 - 6.4 7.0 15.7 7.1 6.8 15.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Peptidase_S49_N PF08496.10 CDI75891.1 - 6.5 6.8 14.1 7.9 6.5 14.1 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal EOS1 PF12326.8 CDI75891.1 - 6.7 6.6 11.8 8 6.4 11.8 1.1 1 0 0 1 1 1 0 N-glycosylation protein Gti1_Pac2 PF09729.9 CDI75891.1 - 7.1 6.7 17.1 8 6.5 17.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF3306 PF11748.8 CDI75891.1 - 7.3 7.5 17.0 10 7.0 17.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Membralin PF09746.9 CDI75891.1 - 7.4 5.5 12.7 8.1 5.4 12.7 1.0 1 0 0 1 1 1 0 Tumour-associated protein PepSY_TM PF03929.16 CDI75891.1 - 7.9 6.0 10.0 8 6.0 10.0 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Usp PF00582.26 CDI75891.1 - 7.9 7.0 6.2 10 6.7 6.2 1.2 1 0 0 1 1 1 0 Universal stress protein family Spore_coat_CotO PF14153.6 CDI75891.1 - 8 6.3 27.9 9.2 6.1 27.9 1.1 1 0 0 1 1 1 0 Spore coat protein CotO BORG_CEP PF14957.6 CDI75891.1 - 8.2 7.6 12.6 10 7.3 12.6 1.1 1 0 0 1 1 1 0 Cdc42 effector DDRGK PF09756.9 CDI75891.1 - 8.3 6.0 28.7 10 5.7 28.7 1.0 1 0 0 1 1 1 0 DDRGK domain Neur_chan_memb PF02932.16 CDI75891.1 - 8.6 6.3 15.2 9.6 6.2 15.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4638 PF15472.6 CDI75891.1 - 9.2 5.9 16.5 9.9 5.8 16.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Band_3_cyto PF07565.13 CDI75891.1 - 9.4 6.0 18.1 12 5.6 18.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RR_TM4-6 PF06459.12 CDI75891.1 - 9.4 6.0 22.0 11 5.8 22.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 CDI75891.1 - 9.4 5.1 24.5 11 4.9 24.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Utp14 PF04615.13 CDI75892.1 - 0.0016 17.1 24.7 0.0018 16.9 24.7 1.0 1 0 0 1 1 1 1 Utp14 protein DUF2232 PF09991.9 CDI75892.1 - 0.13 11.5 3.1 0.19 10.9 3.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) TFIIA PF03153.13 CDI75892.1 - 0.14 12.1 33.6 0.21 11.6 33.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Orai-1 PF07856.12 CDI75892.1 - 0.59 9.8 7.5 0.76 9.4 0.2 2.3 1 1 1 2 2 2 0 Mediator of CRAC channel activity EGF_CA PF07645.15 CDI75894.1 - 9.6e-10 38.5 7.1 1.6e-09 37.8 7.1 1.3 1 0 0 1 1 1 1 Calcium-binding EGF domain EGF_3 PF12947.7 CDI75894.1 - 3.9e-05 23.8 7.1 3.9e-05 23.8 7.1 1.6 1 1 0 1 1 1 1 EGF domain cEGF PF12662.7 CDI75894.1 - 9.9e-05 22.2 6.6 0.0029 17.5 3.9 2.6 2 0 0 2 2 2 1 Complement Clr-like EGF-like FXa_inhibition PF14670.6 CDI75894.1 - 0.00037 20.7 7.7 0.00078 19.7 7.7 1.6 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site EGF PF00008.27 CDI75894.1 - 0.015 15.6 2.8 0.015 15.6 2.8 2.4 2 0 0 2 2 2 0 EGF-like domain NECFESHC PF16621.5 CDI75894.1 - 0.024 14.6 0.1 0.055 13.4 0.1 1.5 1 0 0 1 1 1 0 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 EGF_MSP1_1 PF12946.7 CDI75894.1 - 0.027 14.5 1.6 0.053 13.6 1.6 1.5 1 0 0 1 1 1 0 MSP1 EGF domain 1 hEGF PF12661.7 CDI75894.1 - 0.05 14.3 2.3 0.05 14.3 2.3 2.1 2 0 0 2 2 2 0 Human growth factor-like EGF Peptidase_C11 PF03415.14 CDI75895.1 - 3.2e-12 46.5 0.0 5.7e-11 42.4 0.0 2.1 2 0 0 2 2 2 2 Clostripain family GST_C_6 PF17171.4 CDI75896.1 - 3.6e-08 33.1 0.0 8.8e-08 31.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 CDI75896.1 - 0.00043 20.6 0.0 0.001 19.3 0.0 1.6 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein CLAG PF03805.13 CDI75896.1 - 0.01 13.4 0.0 0.71 7.4 0.0 2.5 2 1 0 2 2 2 0 Cytoadherence-linked asexual protein HemY_N PF07219.13 CDI75896.1 - 2.4 8.4 5.9 3.4 7.9 0.4 2.6 2 0 0 2 2 2 0 HemY protein N-terminus SRP14 PF02290.15 CDI75897.1 - 0.093 13.1 2.6 0.34 11.3 2.6 2.1 1 1 0 1 1 1 0 Signal recognition particle 14kD protein B277 PF17623.2 CDI75898.1 - 8.3 5.4 5.4 14 4.7 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function RIBIOP_C PF04950.12 CDI75899.1 - 1.5e-82 277.3 0.0 2e-71 240.8 0.0 2.2 1 1 1 2 2 2 2 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CDI75899.1 - 4.2e-07 30.0 0.0 1.2e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain CRAL_TRIO PF00650.20 CDI75900.1 - 9.7e-09 35.1 0.2 3.7e-08 33.3 0.1 1.9 1 1 1 2 2 2 1 CRAL/TRIO domain ScdA_N PF04405.14 CDI75901.1 - 0.12 12.0 0.2 0.51 10.0 0.2 2.0 1 0 0 1 1 1 0 Domain of Unknown function (DUF542) Guanylate_cyc PF00211.20 CDI75902.1 - 1.3e-51 174.8 0.1 3e-30 105.2 0.0 4.0 3 2 0 3 3 3 2 Adenylate and Guanylate cyclase catalytic domain Hydrolase PF00702.26 CDI75902.1 - 0.0078 16.5 0.1 0.11 12.8 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CDI75902.1 - 0.0097 15.4 0.2 0.55 9.7 0.0 2.7 2 0 0 2 2 2 1 E1-E2 ATPase TFIIE-A_C PF11521.8 CDI75902.1 - 0.19 12.1 0.1 0.42 10.9 0.1 1.6 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha ABC_tran PF00005.27 CDI75907.1 - 2.8e-50 170.4 0.0 8.6e-27 94.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 CDI75907.1 - 5.1e-35 121.2 23.1 7.7e-27 94.3 4.6 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 CDI75907.1 - 2.1e-16 60.6 0.7 1e-07 32.1 0.0 4.4 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system EF-hand_6 PF13405.6 CDI75907.1 - 7.5e-06 25.5 0.1 3.1e-05 23.5 0.1 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 CDI75907.1 - 3.2e-05 23.2 0.1 0.00011 21.5 0.1 2.0 1 0 0 1 1 1 1 EF hand AAA_29 PF13555.6 CDI75907.1 - 5.4e-05 22.9 1.1 0.11 12.3 0.1 3.2 3 0 0 3 3 3 2 P-loop containing region of AAA domain EF-hand_7 PF13499.6 CDI75907.1 - 0.00018 21.9 0.6 0.016 15.6 0.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair RsgA_GTPase PF03193.16 CDI75907.1 - 0.0015 18.5 0.2 0.039 13.9 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 CDI75907.1 - 0.0018 18.8 2.4 0.06 13.9 0.1 2.6 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 CDI75907.1 - 0.0034 16.8 0.1 12 5.3 0.0 3.7 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain DUF4162 PF13732.6 CDI75907.1 - 0.004 17.8 0.0 3.9 8.3 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4162) Zeta_toxin PF06414.12 CDI75907.1 - 0.019 14.2 0.2 0.12 11.7 0.0 2.3 3 0 0 3 3 3 0 Zeta toxin MMR_HSR1 PF01926.23 CDI75907.1 - 0.026 14.6 1.1 0.36 10.9 0.1 3.0 3 0 0 3 3 3 0 50S ribosome-binding GTPase SbcCD_C PF13558.6 CDI75907.1 - 0.15 12.3 0.0 8.8 6.6 0.0 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 CDI75907.1 - 0.22 11.3 0.1 16 5.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain PCP_red PF08369.10 CDI75907.1 - 0.58 10.4 2.1 1.8 8.9 2.1 1.8 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit eIF-3_zeta PF05091.12 CDI75909.1 - 0.14 11.1 16.3 0.12 11.3 16.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Activator_LAG-3 PF11498.8 CDI75909.1 - 0.21 10.5 41.2 0.21 10.5 41.2 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 S_layer_N PF05123.12 CDI75909.1 - 0.32 10.8 10.0 0.38 10.6 10.0 1.2 1 0 0 1 1 1 0 S-layer like family, N-terminal region FAM60A PF15396.6 CDI75909.1 - 0.34 10.9 9.0 0.32 11.0 9.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SID-1_RNA_chan PF13965.6 CDI75909.1 - 0.44 8.9 4.1 0.43 8.9 4.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Presenilin PF01080.17 CDI75909.1 - 0.74 8.5 17.5 0.75 8.5 17.5 1.1 1 0 0 1 1 1 0 Presenilin Bac_luciferase PF00296.20 CDI75909.1 - 0.78 9.1 21.1 0.88 8.9 21.1 1.0 1 0 0 1 1 1 0 Luciferase-like monooxygenase Baculo_PP31 PF05311.11 CDI75909.1 - 0.87 9.0 11.1 0.82 9.1 11.1 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Neur_chan_memb PF02932.16 CDI75909.1 - 0.89 9.6 8.0 0.83 9.7 8.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SpoIIP PF07454.11 CDI75909.1 - 1 8.7 15.3 1.1 8.7 15.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PAT1 PF09770.9 CDI75909.1 - 1.2 7.4 26.9 1.1 7.4 26.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Velvet PF11754.8 CDI75909.1 - 1.2 9.1 14.4 1.1 9.1 14.4 1.1 1 0 0 1 1 1 0 Velvet factor RR_TM4-6 PF06459.12 CDI75909.1 - 1.2 8.9 15.5 1.1 9.0 15.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 EOS1 PF12326.8 CDI75909.1 - 1.3 9.0 6.0 1.3 9.0 6.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein MMR1 PF08505.10 CDI75909.1 - 1.7 8.9 17.4 1.8 8.8 17.4 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein O-antigen_lig PF13425.6 CDI75909.1 - 1.9 7.2 5.0 1.9 7.2 5.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein TraT PF05818.12 CDI75909.1 - 2 8.1 21.6 2.5 7.7 21.6 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Suf PF05843.14 CDI75909.1 - 2.9 7.8 20.3 3.6 7.5 20.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF726 PF05277.12 CDI75909.1 - 2.9 6.7 6.5 3.3 6.5 6.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DUF1980 PF09323.10 CDI75909.1 - 3.2 7.6 9.6 3.3 7.6 9.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Serinc PF03348.15 CDI75909.1 - 4.2 6.2 10.5 4.3 6.2 10.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DDHD PF02862.17 CDI75909.1 - 4.3 7.4 16.4 4.7 7.3 16.4 1.1 1 0 0 1 1 1 0 DDHD domain TERB2 PF15101.6 CDI75909.1 - 4.8 7.2 26.0 6.3 6.8 26.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DcuA_DcuB PF03605.14 CDI75909.1 - 5.6 5.8 13.7 6.6 5.5 13.7 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Hid1 PF12722.7 CDI75909.1 - 9.3 4.2 14.1 8.4 4.4 14.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SprA-related PF12118.8 CDI75909.1 - 9.6 5.2 41.2 12 5.0 41.2 1.1 1 0 0 1 1 1 0 SprA-related family Dehydrin PF00257.19 CDI75910.1 - 1.1 9.8 5.8 1.2 9.7 5.8 1.1 1 0 0 1 1 1 0 Dehydrin SR-25 PF10500.9 CDI75911.1 - 0.00024 20.8 5.7 0.00024 20.8 5.7 2.5 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein DUF2828 PF11443.8 CDI75911.1 - 2.4 6.1 28.5 0.18 9.8 21.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Presenilin PF01080.17 CDI75911.1 - 2.9 6.5 45.7 1.4 7.6 34.0 2.1 2 0 0 2 2 2 0 Presenilin AF-4 PF05110.13 CDI75911.1 - 4.7 5.2 45.7 0.13 10.3 5.9 2.2 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Tyrosinase PF00264.20 CDI75911.1 - 7.5 6.8 18.1 1.8 8.8 13.6 1.9 2 0 0 2 2 2 0 Common central domain of tyrosinase Acatn PF13000.7 CDI75912.1 - 0.037 12.5 0.0 0.037 12.5 0.0 2.1 2 0 0 2 2 2 0 Acetyl-coenzyme A transporter 1 Hamartin PF04388.12 CDI75912.1 - 0.27 9.9 39.3 0.34 9.5 39.3 1.0 1 0 0 1 1 1 0 Hamartin protein Cwf_Cwc_15 PF04889.12 CDI75912.1 - 0.68 9.6 28.4 0.12 12.1 1.3 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein FAM60A PF15396.6 CDI75912.1 - 3.4 7.6 30.6 5.1 7.0 18.5 2.2 2 0 0 2 2 2 0 Protein Family FAM60A MRP-S31 PF15433.6 CDI75913.1 - 0.2 11.3 20.0 0.27 10.9 20.0 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 PAT1 PF09770.9 CDI75913.1 - 0.24 9.6 25.7 0.28 9.4 25.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1708 PF08101.11 CDI75913.1 - 0.94 8.6 11.1 1.3 8.0 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) RsgA_GTPase PF03193.16 CDI75913.1 - 1.2 9.0 6.3 0.45 10.4 3.1 1.8 1 1 1 2 2 2 0 RsgA GTPase MRP-S26 PF14943.6 CDI75913.1 - 2.5 8.0 22.7 0.44 10.4 9.8 2.1 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 SLC12 PF03522.15 CDI75913.1 - 4.6 6.1 16.6 6.7 5.6 16.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 TFIIA PF03153.13 CDI75914.1 - 0.016 15.2 15.8 0.019 14.9 15.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI75914.1 - 0.11 12.0 9.0 0.15 11.7 9.0 1.1 1 0 0 1 1 1 0 Spt20 family Amastin PF07344.11 CDI75914.1 - 0.14 12.0 4.0 0.25 11.2 4.0 1.5 1 0 0 1 1 1 0 Amastin surface glycoprotein Plasmodium_Vir PF05795.11 CDI75914.1 - 2.7 7.3 3.5 3.3 7.0 3.5 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Ndc1_Nup PF09531.10 CDI75914.1 - 2.8 6.5 13.8 3.4 6.2 13.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RskA PF10099.9 CDI75915.1 - 2.3e-10 41.1 25.9 3.1e-05 24.4 0.0 4.2 2 1 1 3 3 3 1 Anti-sigma-K factor rskA Merozoite_SPAM PF07133.11 CDI75915.1 - 0.0026 17.8 9.6 0.0026 17.8 9.6 1.8 3 0 0 3 3 3 1 Merozoite surface protein (SPAM) DUF2052 PF09747.9 CDI75915.1 - 0.0071 16.5 0.1 0.0071 16.5 0.1 2.8 3 0 0 3 3 3 1 Coiled-coil domain containing protein (DUF2052) SUIM_assoc PF16619.5 CDI75916.1 - 6.4e-10 39.0 28.9 0.23 11.6 8.2 6.3 5 1 0 5 5 5 5 Unstructured region C-term to UIM in Ataxin3 DDDD PF10161.9 CDI75917.1 - 0.32 10.8 1.4 0.44 10.3 0.1 1.9 2 0 0 2 2 2 0 Putative mitochondrial precursor protein Tam41_Mmp37 PF09139.11 CDI75918.1 - 2.3e-21 76.6 0.0 1.2e-15 57.8 0.0 2.3 2 1 0 2 2 2 2 Phosphatidate cytidylyltransferase, mitochondrial SR-25 PF10500.9 CDI75919.1 - 0.00026 20.7 14.5 0.00026 20.7 14.5 2.0 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Chromo PF00385.24 CDI75920.1 - 4e-12 45.8 0.0 8.5e-12 44.8 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 CDI75920.1 - 1.8e-10 41.0 0.0 8.7e-09 35.6 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain IucA_IucC PF04183.12 CDI75920.1 - 0.069 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 IucA / IucC family Glyco_transf_34 PF05637.12 CDI75923.1 - 0.89 9.2 9.5 1.1 8.9 9.5 1.1 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family RskA PF10099.9 CDI75923.1 - 1.4 9.2 42.9 1.5 9.1 27.8 2.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA ADP_ribosyl_GH PF03747.14 CDI75923.1 - 6 6.5 15.5 8.2 6.1 15.5 1.4 1 1 0 1 1 1 0 ADP-ribosylglycohydrolase DDHD PF02862.17 CDI75924.1 - 0.00059 20.1 7.2 0.00059 20.1 7.2 4.2 2 1 0 3 3 3 1 DDHD domain SDA1 PF05285.12 CDI75924.1 - 0.0074 15.8 13.6 0.0074 15.8 13.6 3.7 2 1 1 3 3 3 1 SDA1 SR-25 PF10500.9 CDI75925.1 - 0.0014 18.3 15.5 0.0014 18.3 15.5 6.8 2 2 2 6 6 6 3 Nuclear RNA-splicing-associated protein V_ATPase_I PF01496.19 CDI75925.1 - 0.0037 15.3 13.8 0.0037 15.3 13.8 5.6 3 1 1 5 5 5 1 V-type ATPase 116kDa subunit family DNA_topoisoIV PF00521.20 CDI75926.1 - 6.5e-92 308.6 0.0 1.4e-91 307.6 0.0 1.5 1 1 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 CDI75926.1 - 9.8e-29 100.2 6.4 5.2e-17 62.3 0.2 2.9 2 1 1 3 3 3 2 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 CDI75926.1 - 4.8e-20 71.8 0.2 1e-19 70.7 0.2 1.5 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.22 CDI75926.1 - 1.4e-07 31.7 0.0 3.3e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Toprim domain PBP1_TM PF14812.6 CDI75926.1 - 6.9 7.1 10.4 22 5.5 10.4 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nop14 PF04147.12 CDI75927.1 - 1.3 7.2 18.2 1.6 6.8 18.2 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 CDI75927.1 - 9.2 5.5 34.4 13 5.0 34.4 1.2 1 0 0 1 1 1 0 BUD22 DUF1761 PF08570.10 CDI75928.1 - 0.017 15.4 4.1 0.024 14.9 4.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1761) Dehydrin PF00257.19 CDI75928.1 - 0.025 15.1 9.6 0.025 15.1 9.6 2.1 1 1 1 2 2 2 0 Dehydrin RskA PF10099.9 CDI75928.1 - 0.052 13.8 50.2 0.046 14.0 17.5 2.0 1 1 1 2 2 2 0 Anti-sigma-K factor rskA EphA2_TM PF14575.6 CDI75928.1 - 0.55 11.1 8.3 25 5.8 8.3 2.3 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Semialdhyde_dhC PF02774.18 CDI75928.1 - 1.3 9.1 12.9 1.5 8.9 12.9 1.0 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, dimerisation domain PPP4R2 PF09184.11 CDI75928.1 - 1.6 8.2 7.8 1.8 8.1 7.8 1.1 1 0 0 1 1 1 0 PPP4R2 DUF4179 PF13786.6 CDI75928.1 - 2.2 8.8 19.1 2 8.9 5.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4179) Menin PF05053.13 CDI75928.1 - 2.6 6.3 20.0 3 6.1 20.0 1.1 1 0 0 1 1 1 0 Menin SUIM_assoc PF16619.5 CDI75928.1 - 2.9 8.0 45.6 0.085 12.9 14.8 3.0 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF4667 PF15700.5 CDI75928.1 - 5.6 7.0 17.4 7.6 6.5 17.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) Allantoicase PF03561.15 CDI75928.1 - 6.7 6.7 12.4 0.76 9.7 4.7 2.6 1 1 1 2 2 2 0 Allantoicase repeat CDC27 PF09507.10 CDI75928.1 - 7.1 5.9 24.4 8 5.7 24.4 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SLC12 PF03522.15 CDI75928.1 - 9.9 5.1 14.4 11 4.9 14.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Caldesmon PF02029.15 CDI75929.1 - 0.037 12.8 17.5 0.039 12.7 17.5 1.0 1 0 0 1 1 1 0 Caldesmon Asp-B-Hydro_N PF05279.11 CDI75929.1 - 0.38 10.8 16.7 0.42 10.7 16.7 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region AAA_23 PF13476.6 CDI75929.1 - 0.83 10.1 15.4 0.92 10.0 15.4 1.2 1 0 0 1 1 1 0 AAA domain DDHD PF02862.17 CDI75929.1 - 8.6 6.5 14.1 10 6.2 14.1 1.2 1 0 0 1 1 1 0 DDHD domain TFIIA PF03153.13 CDI75929.1 - 9.1 6.2 45.1 12 5.7 45.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tho2 PF11262.8 CDI75930.1 - 9.2 5.4 11.6 3.4 6.8 2.3 2.7 3 0 0 3 3 3 0 Transcription factor/nuclear export subunit protein 2 MFS_1 PF07690.16 CDI75931.1 - 1.7e-21 76.5 0.3 5.3e-15 55.2 0.1 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CDI75931.1 - 2e-09 36.3 0.3 4.4e-08 31.9 0.0 2.2 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.6 CDI75931.1 - 1.5e-06 27.1 0.5 4.2e-06 25.6 0.2 1.7 1 1 1 2 2 2 1 MFS/sugar transport protein Sugar_tr PF00083.24 CDI75931.1 - 8.6e-05 21.6 4.6 0.45 9.3 0.6 3.1 2 1 0 3 3 3 3 Sugar (and other) transporter DUF4199 PF13858.6 CDI75931.1 - 0.051 14.0 1.6 3.3 8.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) G0-G1_switch_2 PF15103.6 CDI75931.1 - 0.073 13.5 13.3 0.12 12.8 0.1 3.2 3 0 0 3 3 3 0 G0/G1 switch protein 2 CPSF100_C PF13299.6 CDI75931.1 - 0.12 12.6 15.5 0.056 13.6 0.8 3.5 4 0 0 4 4 4 0 Cleavage and polyadenylation factor 2 C-terminal FPN1 PF06963.12 CDI75931.1 - 0.3 9.6 3.1 4.3 5.8 1.4 2.5 2 1 0 2 2 2 0 Ferroportin1 (FPN1) Pex14_N PF04695.13 CDI75931.1 - 0.47 11.1 28.3 0.2 12.3 0.3 4.5 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FHIPEP PF00771.20 CDI75931.1 - 0.52 8.7 4.7 2.3 6.6 0.5 2.1 2 0 0 2 2 2 0 FHIPEP family DUF2371 PF10177.9 CDI75931.1 - 0.72 10.0 3.3 4.9 7.3 0.0 2.9 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2371) DUF3464 PF11947.8 CDI75931.1 - 2.1 8.1 0.0 2.1 8.1 0.0 3.6 4 0 0 4 4 4 0 Photosynthesis affected mutant 68 CLN3 PF02487.17 CDI75931.1 - 3.6 6.5 9.0 0.38 9.7 0.1 2.6 3 0 0 3 3 3 0 CLN3 protein DUF2828 PF11443.8 CDI75931.1 - 9.2 4.2 10.0 6.4 4.7 3.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF2828) DUF1003 PF06210.11 CDI75933.1 - 0.042 14.0 0.1 0.074 13.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) SelP_N PF04592.14 CDI75936.1 - 0.045 13.1 31.4 0.067 12.6 19.2 2.1 2 0 0 2 2 2 0 Selenoprotein P, N terminal region U1snRNP70_N PF12220.8 CDI75936.1 - 0.74 10.5 28.2 3.1 8.5 13.3 2.4 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Afi1 PF07792.12 CDI75936.1 - 2.4 8.6 25.2 2.8 8.4 10.1 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Peptidase_S49_N PF08496.10 CDI75936.1 - 2.7 8.0 31.6 0.26 11.3 13.3 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal SAGA-Tad1 PF12767.7 CDI75936.1 - 3.3 7.4 24.6 4.6 6.9 24.6 1.3 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit RskA PF10099.9 CDI75936.1 - 3.4 7.9 62.7 0.33 11.2 29.5 2.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Peptidase_U57 PF05582.12 CDI75936.1 - 4.9 6.3 24.6 2.6 7.2 12.3 2.1 2 0 0 2 2 2 0 YabG peptidase U57 Pap_E4 PF02711.14 CDI75936.1 - 8.3 7.4 24.9 3.5 8.6 5.9 2.4 2 0 0 2 2 2 0 E4 protein Paf1 PF03985.13 CDI75936.1 - 8.6 5.2 35.3 0.73 8.8 15.9 2.1 2 0 0 2 2 2 0 Paf1 Polysacc_synt_3 PF13440.6 CDI75937.1 - 0.028 13.6 0.4 0.043 13.0 0.4 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein PPP4R2 PF09184.11 CDI75937.1 - 0.083 12.5 16.7 0.1 12.2 16.7 1.1 1 0 0 1 1 1 0 PPP4R2 Macoilin PF09726.9 CDI75937.1 - 0.11 11.0 33.2 0.14 10.7 33.2 1.2 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 CDI75937.1 - 0.12 12.3 27.1 0.16 11.8 27.1 1.2 1 0 0 1 1 1 0 SPX domain PAC4 PF16093.5 CDI75937.1 - 1.4 9.1 16.9 0.029 14.6 6.0 2.3 1 1 1 2 2 2 0 Proteasome assembly chaperone 4 WD40 PF00400.32 CDI75939.1 - 9.4e-09 35.8 8.8 0.053 14.4 0.0 4.4 4 1 1 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI75939.1 - 0.05 13.9 0.0 0.83 10.0 0.0 2.7 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain SUIM_assoc PF16619.5 CDI75939.1 - 0.1 12.7 52.6 0.23 11.6 3.5 4.6 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 Med15 PF09606.10 CDI75939.1 - 1.4 7.5 37.2 0.71 8.5 27.4 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal SR-25 PF10500.9 CDI75939.1 - 9.1 5.8 24.3 16 5.0 0.1 2.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CobT PF06213.12 CDI75942.1 - 0.021 14.2 19.0 0.021 14.2 19.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 CDI75942.1 - 0.054 13.7 11.6 0.052 13.7 11.6 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal PP_kinase_N PF13089.6 CDI75942.1 - 0.098 13.0 11.9 0.12 12.7 11.9 1.2 1 0 0 1 1 1 0 Polyphosphate kinase N-terminal domain TERB2 PF15101.6 CDI75942.1 - 0.12 12.5 23.5 0.12 12.4 23.5 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DDHD PF02862.17 CDI75942.1 - 0.18 12.0 14.2 0.17 12.0 14.2 1.0 1 0 0 1 1 1 0 DDHD domain DUF913 PF06025.12 CDI75942.1 - 0.33 9.9 8.2 0.31 10.0 8.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Band_3_cyto PF07565.13 CDI75942.1 - 0.55 10.0 16.7 0.56 10.0 16.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Sugar_tr PF00083.24 CDI75942.1 - 0.62 8.9 3.1 0.65 8.8 3.1 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter Peroxin-13_N PF04088.13 CDI75942.1 - 0.91 9.8 11.2 0.96 9.7 11.2 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Pex14_N PF04695.13 CDI75942.1 - 1.2 9.8 27.4 1.2 9.8 27.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SID-1_RNA_chan PF13965.6 CDI75942.1 - 1.4 7.2 7.6 1.3 7.4 7.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SpoIIP PF07454.11 CDI75942.1 - 1.7 8.1 20.1 1.7 8.0 20.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CDI75942.1 - 1.7 7.3 20.5 1.7 7.4 20.5 1.0 1 0 0 1 1 1 0 Presenilin EIIBC-GUT_N PF03612.14 CDI75942.1 - 2 8.1 15.7 2.2 8.0 15.7 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Otopetrin PF03189.13 CDI75942.1 - 2.4 6.9 9.3 2.3 6.9 9.3 1.0 1 0 0 1 1 1 0 Otopetrin DUF4746 PF15928.5 CDI75942.1 - 2.6 7.4 12.2 2.6 7.4 12.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Baculo_PP31 PF05311.11 CDI75942.1 - 2.8 7.4 18.5 3 7.3 18.5 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) FAM60A PF15396.6 CDI75942.1 - 3 7.8 14.2 3 7.8 14.2 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Tim54 PF11711.8 CDI75942.1 - 3 6.5 15.9 3.1 6.5 15.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Folliculin PF11704.8 CDI75942.1 - 3.3 7.5 16.5 3.6 7.4 16.5 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport RR_TM4-6 PF06459.12 CDI75942.1 - 3.5 7.4 17.9 3.5 7.4 17.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CCDC53 PF10152.9 CDI75942.1 - 3.7 8.0 18.4 3.7 8.0 18.4 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Neur_chan_memb PF02932.16 CDI75942.1 - 5.7 6.9 15.3 6 6.9 15.3 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TFB6 PF17110.5 CDI75942.1 - 5.9 6.6 13.1 6.8 6.4 13.1 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Cellulose_synt PF03552.14 CDI75942.1 - 6.7 5.1 6.9 6.1 5.2 6.9 1.0 1 0 0 1 1 1 0 Cellulose synthase Gti1_Pac2 PF09729.9 CDI75942.1 - 7.3 6.6 15.5 7.9 6.5 15.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family AIF_C PF14721.6 CDI75942.1 - 7.4 6.9 16.7 9.2 6.6 16.7 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term MDM10 PF12519.8 CDI75942.1 - 7.9 5.2 15.0 7.6 5.3 15.0 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CSG2 PF16965.5 CDI75942.1 - 8 5.3 11.4 7.9 5.3 11.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator G0-G1_switch_2 PF15103.6 CDI75942.1 - 8.2 6.9 14.0 12 6.4 14.0 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 Ctr PF04145.15 CDI75942.1 - 9.2 6.9 14.0 10 6.7 14.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family AAA_23 PF13476.6 CDI75942.1 - 9.5 6.7 21.8 9.6 6.6 21.8 1.2 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CDI75943.1 - 0.0017 18.9 11.1 0.0023 18.4 11.1 1.1 1 0 0 1 1 1 1 AAA domain DUF4912 PF16258.5 CDI75943.1 - 0.027 14.7 1.5 0.067 13.4 1.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4912) RAP1 PF07218.11 CDI75944.1 - 0.078 11.3 13.0 0.082 11.2 13.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RTC_insert PF05189.13 CDI75945.1 - 3.2e-11 43.7 20.8 1.3e-08 35.2 20.8 3.4 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain FAM176 PF14851.6 CDI75946.1 - 0.088 12.5 4.9 0.091 12.4 4.9 1.2 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 CDI75946.1 - 0.15 10.2 5.8 0.14 10.2 5.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi SMN PF06003.12 CDI75946.1 - 0.16 11.2 3.3 0.18 11.0 3.3 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) CDC45 PF02724.14 CDI75946.1 - 0.47 8.7 9.3 0.42 8.9 9.3 1.0 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 CDI75946.1 - 0.87 8.3 7.2 0.82 8.4 7.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Merozoite_SPAM PF07133.11 CDI75946.1 - 1 9.3 20.8 1.3 9.0 20.8 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) BAF1_ABF1 PF04684.13 CDI75946.1 - 2.3 7.2 9.8 2.9 6.9 9.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Paf1 PF03985.13 CDI75946.1 - 2.7 6.9 13.1 2.9 6.8 13.1 1.0 1 0 0 1 1 1 0 Paf1 DUF2151 PF10221.9 CDI75946.1 - 3.1 6.3 5.6 3.1 6.3 5.6 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator DUF2057 PF09829.9 CDI75946.1 - 3.3 7.8 6.6 3.8 7.6 6.6 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) Presenilin PF01080.17 CDI75946.1 - 3.8 6.2 8.2 3.6 6.2 8.2 1.1 1 0 0 1 1 1 0 Presenilin PRP38_assoc PF12871.7 CDI75946.1 - 3.8 8.2 34.9 8 7.1 34.9 1.5 1 1 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term SAPS PF04499.15 CDI75946.1 - 7.1 5.3 7.1 7.2 5.3 7.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4746 PF15928.5 CDI75946.1 - 7.6 5.9 10.7 8.2 5.8 10.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SDA1 PF05285.12 CDI75947.1 - 0.016 14.7 17.3 0.018 14.5 17.3 1.1 1 0 0 1 1 1 0 SDA1 RecO_C PF02565.15 CDI75947.1 - 0.061 13.1 4.7 0.032 14.0 2.9 1.6 1 1 0 1 1 1 0 Recombination protein O C terminal NMO PF03060.15 CDI75947.1 - 0.08 12.3 0.5 0.11 11.8 0.5 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase SR-25 PF10500.9 CDI75947.1 - 0.28 10.8 27.8 1.1 8.8 28.1 1.7 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein SAGA-Tad1 PF12767.7 CDI75947.1 - 0.29 10.8 24.6 0.35 10.6 24.6 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit O-antigen_lig PF13425.6 CDI75947.1 - 0.71 8.6 9.2 0.78 8.5 9.2 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Miga PF10265.9 CDI75947.1 - 1.8 7.5 18.4 2.2 7.2 18.4 1.1 1 0 0 1 1 1 0 Mitoguardin EIF4E-T PF10477.9 CDI75947.1 - 2 7.1 40.2 2.3 7.0 40.2 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Plasmodium_Vir PF05795.11 CDI75947.1 - 3.8 6.8 11.8 5.4 6.3 11.8 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Menin PF05053.13 CDI75947.1 - 7.1 4.9 15.3 8.3 4.6 15.3 1.1 1 0 0 1 1 1 0 Menin FAD_oxidored PF12831.7 CDI75947.1 - 8.1 5.7 14.1 9.4 5.5 14.1 1.0 1 0 0 1 1 1 0 FAD dependent oxidoreductase Exonuc_VII_L PF02601.15 CDI75948.1 - 0.00089 18.9 17.5 0.00089 18.9 17.5 2.2 2 0 0 2 2 2 1 Exonuclease VII, large subunit DUF908 PF06012.12 CDI75948.1 - 0.029 13.8 18.0 1.3 8.4 0.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) DUF2722 PF10846.8 CDI75948.1 - 0.058 12.3 0.2 0.058 12.3 0.2 4.1 2 1 2 4 4 4 0 Protein of unknown function (DUF2722) Presenilin PF01080.17 CDI75948.1 - 0.077 11.8 29.8 0.29 9.9 25.1 2.2 2 0 0 2 2 2 0 Presenilin SpoIIP PF07454.11 CDI75948.1 - 1.6 8.1 23.1 5.3 6.4 18.3 2.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Band_3_cyto PF07565.13 CDI75948.1 - 3 7.6 30.2 28 4.4 27.1 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Caldesmon PF02029.15 CDI75948.1 - 3.2 6.4 32.5 0.057 12.2 21.9 2.1 2 0 0 2 2 2 0 Caldesmon LMBR1 PF04791.16 CDI75948.1 - 3.9 6.3 12.1 5.4 5.8 12.1 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Rhodanese PF00581.20 CDI75949.1 - 2.8e-14 53.5 0.4 0.0016 18.9 0.0 3.3 3 0 0 3 3 3 3 Rhodanese-like domain DUF2235 PF09994.9 CDI75949.1 - 0.00015 21.2 0.1 0.4 10.0 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized alpha/beta hydrolase domain (DUF2235) Secretin_N_2 PF07655.13 CDI75949.1 - 0.0047 17.4 5.7 0.0047 17.4 5.7 4.0 3 1 1 4 4 3 1 Secretin N-terminal domain DUF1645 PF07816.11 CDI75949.1 - 0.009 16.6 2.9 0.009 16.6 2.9 4.5 5 0 0 5 5 5 1 Protein of unknown function (DUF1645) TMEM132D_C PF15706.5 CDI75949.1 - 0.046 13.5 1.2 0.55 10.1 0.0 2.6 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF2417 PF10329.9 CDI75949.1 - 0.087 12.2 0.5 4.6 6.6 0.3 2.3 2 0 0 2 2 2 0 Region of unknown function (DUF2417) DUF4064 PF13273.6 CDI75949.1 - 0.16 12.3 3.6 1.1 9.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) MH2 PF03166.14 CDI75949.1 - 0.17 12.1 4.9 3.9 7.7 0.4 2.5 2 0 0 2 2 2 0 MH2 domain HD_6 PF18019.1 CDI75949.1 - 0.4 10.8 7.2 0.097 12.8 0.7 2.2 2 0 0 2 2 2 0 HD domain FHIPEP PF00771.20 CDI75949.1 - 0.51 8.7 8.3 3.3 6.1 0.1 2.3 2 0 0 2 2 2 0 FHIPEP family Glt_symporter PF03616.14 CDI75949.1 - 0.6 8.7 2.0 3.2 6.3 0.2 2.1 2 0 0 2 2 2 0 Sodium/glutamate symporter TMEM82 PF15816.5 CDI75949.1 - 0.63 9.0 4.4 1 8.3 0.1 2.3 2 0 0 2 2 2 0 Transmembrane protein 82 DUF4199 PF13858.6 CDI75949.1 - 0.92 9.9 6.6 7.4 6.9 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) MTP18 PF10558.9 CDI75949.1 - 2 8.3 6.5 14 5.6 4.0 2.5 2 0 0 2 2 2 0 Mitochondrial 18 KDa protein (MTP18) DUF3464 PF11947.8 CDI75949.1 - 2.1 8.1 17.9 1.3 8.8 0.1 3.8 4 0 0 4 4 4 0 Photosynthesis affected mutant 68 MecA PF05389.12 CDI75949.1 - 2.3 7.8 16.1 3.6 7.1 0.1 3.4 4 0 0 4 4 4 0 Negative regulator of genetic competence (MecA) DUF4446 PF14584.6 CDI75949.1 - 4.2 7.3 10.4 3.9 7.4 3.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Ureide_permease PF07168.11 CDI75949.1 - 5.1 5.8 6.3 2.7 6.7 0.1 2.4 2 0 0 2 2 2 0 Ureide permease DUF2076 PF09849.9 CDI75949.1 - 5.3 7.0 37.1 0.079 13.0 5.2 4.0 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2076) OmpH PF03938.14 CDI75949.1 - 5.3 7.4 46.2 2.7 8.3 16.7 3.2 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) Zn_peptidase PF04228.13 CDI75949.1 - 8.1 5.8 16.7 16 4.8 0.6 3.4 3 0 0 3 3 3 0 Putative neutral zinc metallopeptidase RskA PF10099.9 CDI75951.1 - 0.012 15.9 29.0 0.097 13.0 29.0 2.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF4746 PF15928.5 CDI75951.1 - 0.019 14.4 5.6 0.03 13.7 5.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Exonuc_VII_L PF02601.15 CDI75951.1 - 0.035 13.7 17.7 0.063 12.8 17.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit AF-4 PF05110.13 CDI75951.1 - 0.78 7.8 36.3 0.45 8.6 13.5 2.2 2 0 0 2 2 2 0 AF-4 proto-oncoprotein DUF2347 PF09804.9 CDI75951.1 - 2.6 7.6 12.4 0.15 11.6 7.1 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2347) Peptidase_S49_N PF08496.10 CDI75951.1 - 2.7 8.1 14.5 4.1 7.5 14.5 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FAM60A PF15396.6 CDI75951.1 - 2.9 7.9 21.0 8.4 6.3 17.0 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Macoilin PF09726.9 CDI75951.1 - 3.4 6.1 29.1 2.8 6.4 3.7 2.1 2 0 0 2 2 2 0 Macoilin family TERB2 PF15101.6 CDI75951.1 - 3.6 7.6 21.7 0.15 12.1 14.4 2.0 2 0 0 2 2 2 0 Telomere-associated protein TERB2 TFIIA PF03153.13 CDI75951.1 - 4.7 7.1 49.8 7.5 6.4 49.8 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CoA_binding PF02629.19 CDI75952.1 - 4.7e-26 91.3 0.0 1.4e-25 89.8 0.0 1.8 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 CDI75952.1 - 5.5e-11 42.5 0.7 2.9e-09 36.9 0.2 2.2 1 1 1 2 2 2 2 CoA-ligase LpxD PF04613.14 CDI75952.1 - 0.11 12.3 0.5 1.4 8.7 0.2 2.3 2 0 0 2 2 2 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD DUF384 PF04064.13 CDI75953.1 - 1.7e-10 40.6 0.0 4.7e-10 39.2 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF384) CAF1 PF04857.20 CDI75953.1 - 0.00074 18.8 3.6 0.014 14.6 1.9 2.1 2 0 0 2 2 2 1 CAF1 family ribonuclease DUF383 PF04063.14 CDI75953.1 - 0.0074 16.0 0.0 0.0074 16.0 0.0 3.0 2 2 1 3 3 2 1 Domain of unknown function (DUF383) DUF2828 PF11443.8 CDI75953.1 - 0.23 9.5 9.3 0.024 12.7 5.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Presenilin PF01080.17 CDI75953.1 - 0.3 9.8 11.5 0.064 12.0 7.6 1.8 2 0 0 2 2 2 0 Presenilin Serinc PF03348.15 CDI75953.1 - 0.42 9.5 4.0 0.88 8.4 4.0 1.5 1 0 0 1 1 1 0 Serine incorporator (Serinc) GalP_UDP_transf PF01087.22 CDI75953.1 - 2 8.8 14.8 2.2 8.7 7.5 2.5 3 0 0 3 3 3 0 Galactose-1-phosphate uridyl transferase, N-terminal domain Orf78 PF06024.12 CDI75953.1 - 3.4 8.0 7.9 19 5.7 3.3 3.0 3 0 0 3 3 3 0 Orf78 (ac78) DUF4192 PF13830.6 CDI75953.1 - 3.9 7.5 12.6 5.8 6.9 6.8 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4192) DUF4407 PF14362.6 CDI75953.1 - 5.1 6.4 15.3 1.3 8.3 10.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Porph_ging PF09697.10 CDI75953.1 - 6.5 7.4 0.0 6.5 7.4 0.0 3.4 4 0 0 4 4 3 0 Protein of unknown function (Porph_ging) DUF3362 PF11842.8 CDI75953.1 - 7.6 6.8 16.9 3.1 8.1 6.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3362) SLC12 PF03522.15 CDI75953.1 - 7.7 5.4 11.3 1.5 7.8 7.5 1.6 2 0 0 2 2 2 0 Solute carrier family 12 V_ATPase_I PF01496.19 CDI75953.1 - 7.8 4.3 10.5 0.6 8.0 5.6 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Peptidase_C14 PF00656.22 CDI75954.1 - 2e-21 77.1 0.0 5.5e-20 72.4 0.0 3.0 2 1 0 2 2 2 1 Caspase domain Ysc84 PF04366.12 CDI75956.1 - 9.6 6.0 6.7 9.7 6.0 0.6 2.5 2 1 0 2 2 2 0 Las17-binding protein actin regulator Cpn60_TCP1 PF00118.24 CDI75957.1 - 9.1e-23 80.6 0.1 9.9e-23 80.5 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family UBA PF00627.31 CDI75960.1 - 5.7e-08 32.5 0.5 1.9e-07 30.8 0.5 2.0 1 0 0 1 1 1 1 UBA/TS-N domain PUB PF09409.10 CDI75960.1 - 0.00015 21.6 0.0 0.0017 18.3 0.0 2.2 2 0 0 2 2 2 1 PUB domain TFIIA PF03153.13 CDI75960.1 - 0.0069 16.4 30.3 0.0085 16.1 30.3 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SMYLE_N PF18615.1 CDI75960.1 - 0.063 12.8 7.9 0.081 12.5 7.9 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain DUF327 PF03885.13 CDI75960.1 - 0.49 10.4 9.9 3.3 7.7 5.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF327) DUF2722 PF10846.8 CDI75960.1 - 1.1 8.1 12.2 1.9 7.4 12.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) RAB3GAP2_N PF14655.6 CDI75960.1 - 2 7.6 9.2 1.7 7.8 8.1 1.3 1 1 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF4820 PF16091.5 CDI75960.1 - 2.7 7.3 7.8 0.36 10.2 3.3 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4820) Spt20 PF12090.8 CDI75960.1 - 6.4 6.3 20.0 0.35 10.4 14.8 1.7 2 0 0 2 2 2 0 Spt20 family SURF6 PF04935.12 CDI75961.1 - 0.0048 16.7 14.4 0.0048 16.7 14.4 4.1 4 0 0 4 4 4 1 Surfeit locus protein 6 DUF3040 PF11239.8 CDI75961.1 - 0.18 12.1 8.4 0.42 10.9 4.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) SpoIIP PF07454.11 CDI75961.1 - 0.29 10.6 19.9 0.031 13.8 11.2 2.7 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) PPL5 PF18168.1 CDI75961.1 - 1.1 8.5 17.6 0.56 9.4 12.3 2.7 3 0 0 3 3 3 0 Prim-pol family 5 HCO3_cotransp PF00955.21 CDI75961.1 - 5 5.8 6.6 14 4.3 6.6 1.7 1 0 0 1 1 1 0 HCO3- transporter family TFIIA PF03153.13 CDI75962.1 - 0.016 15.3 48.4 0.017 15.2 48.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI75962.1 - 0.02 13.7 24.7 0.022 13.6 24.7 1.0 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 CDI75962.1 - 0.021 13.8 9.9 0.021 13.8 9.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Rtf2 PF04641.12 CDI75962.1 - 0.035 13.5 13.8 0.039 13.3 13.8 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger DUF4746 PF15928.5 CDI75962.1 - 0.037 13.4 11.6 0.041 13.3 11.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DDHD PF02862.17 CDI75962.1 - 0.038 14.2 15.6 0.045 13.9 15.6 1.2 1 0 0 1 1 1 0 DDHD domain CobT PF06213.12 CDI75962.1 - 0.043 13.2 30.5 0.066 12.6 30.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SpoIIP PF07454.11 CDI75962.1 - 0.049 13.1 20.5 0.055 12.9 20.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SAPS PF04499.15 CDI75962.1 - 0.049 12.4 12.1 0.051 12.4 12.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Velvet PF11754.8 CDI75962.1 - 0.052 13.5 17.1 0.053 13.5 17.1 1.1 1 0 0 1 1 1 0 Velvet factor Endostatin PF06482.11 CDI75962.1 - 0.056 12.9 16.8 0.06 12.8 16.8 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SID-1_RNA_chan PF13965.6 CDI75962.1 - 0.067 11.6 6.6 0.067 11.6 6.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Pex14_N PF04695.13 CDI75962.1 - 0.081 13.6 34.7 0.098 13.3 34.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HGTP_anticodon2 PF12745.7 CDI75962.1 - 0.084 12.4 14.4 0.096 12.2 14.4 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs PIP5K PF01504.18 CDI75962.1 - 0.092 12.0 13.1 0.098 11.9 13.1 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Baculo_PP31 PF05311.11 CDI75962.1 - 0.097 12.1 14.0 0.11 12.0 14.0 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) SLC12 PF03522.15 CDI75962.1 - 0.1 11.6 18.6 0.1 11.6 18.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF3807 PF12720.7 CDI75962.1 - 0.11 12.8 26.2 0.15 12.4 26.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Band_3_cyto PF07565.13 CDI75962.1 - 0.11 12.2 15.6 0.13 12.1 15.6 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CLN3 PF02487.17 CDI75962.1 - 0.12 11.4 13.2 0.13 11.3 13.2 1.1 1 0 0 1 1 1 0 CLN3 protein CCDC53 PF10152.9 CDI75962.1 - 0.14 12.6 23.6 0.17 12.3 23.6 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex eIF-3_zeta PF05091.12 CDI75962.1 - 0.15 11.0 26.1 0.17 10.8 26.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Serinc PF03348.15 CDI75962.1 - 0.19 10.6 8.7 0.18 10.7 8.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF3295 PF11702.8 CDI75962.1 - 0.2 11.0 24.4 0.23 10.8 24.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) RR_TM4-6 PF06459.12 CDI75962.1 - 0.23 11.2 21.5 0.27 11.0 21.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 CDI75962.1 - 0.32 9.8 16.0 0.32 9.8 16.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter TAF4 PF05236.14 CDI75962.1 - 0.32 10.7 21.8 0.42 10.3 21.8 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family CPSF100_C PF13299.6 CDI75962.1 - 0.36 11.0 18.2 0.44 10.7 18.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF1980 PF09323.10 CDI75962.1 - 0.36 10.7 12.7 0.45 10.4 12.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Paf1 PF03985.13 CDI75962.1 - 0.42 9.6 22.5 0.49 9.3 22.5 1.1 1 0 0 1 1 1 0 Paf1 PAT1 PF09770.9 CDI75962.1 - 0.42 8.8 37.5 0.43 8.8 37.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 YjbH PF06082.11 CDI75962.1 - 0.47 9.2 15.3 0.51 9.1 15.3 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH BORG_CEP PF14957.6 CDI75962.1 - 0.53 11.4 14.2 0.68 11.1 14.2 1.2 1 0 0 1 1 1 0 Cdc42 effector GREB1 PF15782.5 CDI75962.1 - 0.53 7.3 20.2 0.5 7.4 20.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PTPRCAP PF15713.5 CDI75962.1 - 0.55 10.5 22.0 0.6 10.4 22.0 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CCSAP PF15748.5 CDI75962.1 - 0.68 10.1 23.6 0.81 9.8 23.6 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DNApol_Exo PF18136.1 CDI75962.1 - 0.9 8.6 13.2 1.1 8.3 13.2 1.3 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain CSG2 PF16965.5 CDI75962.1 - 0.95 8.3 10.3 1 8.2 10.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2828 PF11443.8 CDI75962.1 - 1 7.4 19.7 1.2 7.2 19.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4638 PF15472.6 CDI75962.1 - 1.1 8.9 16.1 1.2 8.8 16.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) VIR_N PF15912.5 CDI75962.1 - 1.3 8.6 11.5 1.4 8.4 11.5 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DUF1180 PF06679.12 CDI75962.1 - 1.3 9.4 10.9 1.6 9.1 10.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) API5 PF05918.11 CDI75962.1 - 1.4 7.7 20.1 1.6 7.5 20.1 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Pannexin_like PF12534.8 CDI75962.1 - 1.5 7.8 15.1 1.7 7.7 15.1 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Ctr PF04145.15 CDI75962.1 - 1.6 9.4 10.4 2 9.0 10.4 1.4 1 0 0 1 1 1 0 Ctr copper transporter family DUF908 PF06012.12 CDI75962.1 - 1.8 7.9 19.4 1.9 7.8 19.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) AIF_C PF14721.6 CDI75962.1 - 1.8 8.9 17.8 3 8.2 17.8 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term PPP4R2 PF09184.11 CDI75962.1 - 1.8 8.1 13.1 2.2 7.8 13.1 1.1 1 0 0 1 1 1 0 PPP4R2 CBP_BcsG PF11658.8 CDI75962.1 - 2 6.7 16.3 2.2 6.6 16.3 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Glyco_transf_41 PF13844.6 CDI75962.1 - 2.3 6.6 10.8 2.3 6.6 10.8 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 DUF1387 PF07139.11 CDI75962.1 - 2.4 7.8 25.0 2.8 7.6 25.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) CDC45 PF02724.14 CDI75962.1 - 2.9 6.1 18.2 3.5 5.8 18.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Lin-8 PF03353.15 CDI75962.1 - 3.2 7.2 28.3 3.6 7.1 28.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Zip PF02535.22 CDI75962.1 - 3.6 6.7 11.0 3.9 6.6 11.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Hid1 PF12722.7 CDI75962.1 - 4.3 5.3 23.4 4.9 5.2 23.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM60A PF15396.6 CDI75962.1 - 4.4 7.3 17.7 5.4 7.0 17.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF2464 PF10240.9 CDI75962.1 - 4.6 6.7 15.9 5.2 6.6 15.9 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 Peptidase_S15 PF02129.18 CDI75962.1 - 5.3 6.5 16.4 5.8 6.4 16.4 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) SART-1 PF03343.13 CDI75962.1 - 5.8 5.3 27.4 7.4 5.0 27.4 1.0 1 0 0 1 1 1 0 SART-1 family 5_nucleotid PF05761.14 CDI75962.1 - 6.8 5.5 17.7 8.7 5.1 17.7 1.0 1 0 0 1 1 1 0 5' nucleotidase family MAJIN PF15077.6 CDI75962.1 - 6.9 6.4 16.3 8.1 6.1 16.3 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein HCO3_cotransp PF00955.21 CDI75962.1 - 7.8 5.2 10.1 8.4 5.1 10.1 1.1 1 0 0 1 1 1 0 HCO3- transporter family Bul1_N PF04425.12 CDI75962.1 - 7.9 5.1 18.7 9 4.9 18.7 1.1 1 0 0 1 1 1 0 Bul1 N terminus EIF4E-T PF10477.9 CDI75962.1 - 8.8 5.0 38.2 10 4.8 38.2 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E FAM176 PF14851.6 CDI75962.1 - 9 6.0 14.6 12 5.5 14.6 1.3 1 0 0 1 1 1 0 FAM176 family SpoIIE PF07228.12 CDI75966.1 - 9.4e-06 25.7 0.0 0.00012 22.1 0.0 2.5 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 CDI75966.1 - 9.6e-05 22.1 0.0 0.00024 20.8 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 CDI75966.1 - 0.051 13.2 0.0 1.3 8.6 0.0 2.2 2 0 0 2 2 2 0 Protein phosphatase 2C IMUP PF15761.5 CDI75966.1 - 0.053 14.2 9.9 0.13 13.0 9.9 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 CDI75966.1 - 0.29 10.7 10.5 0.52 9.9 10.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RPN2_C PF18004.1 CDI75967.1 - 0.0058 16.6 10.1 0.0082 16.1 10.1 1.2 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain baeRF_family10 PF18854.1 CDI75967.1 - 0.022 15.0 9.1 0.034 14.4 9.1 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 DcuA_DcuB PF03605.14 CDI75967.1 - 0.032 13.1 2.2 0.033 13.1 2.2 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter SID-1_RNA_chan PF13965.6 CDI75967.1 - 0.042 12.3 6.8 0.041 12.3 6.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Presenilin PF01080.17 CDI75967.1 - 0.055 12.2 12.2 0.063 12.0 12.2 1.2 1 0 0 1 1 1 0 Presenilin DUF4228 PF14009.6 CDI75967.1 - 0.095 13.1 5.3 0.11 12.9 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) TMEM51 PF15345.6 CDI75967.1 - 0.1 12.4 11.6 0.13 12.1 11.6 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 Tim54 PF11711.8 CDI75967.1 - 0.11 11.3 12.0 0.13 11.0 12.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FAM176 PF14851.6 CDI75967.1 - 0.11 12.1 6.0 0.16 11.7 6.0 1.3 1 0 0 1 1 1 0 FAM176 family CLN3 PF02487.17 CDI75967.1 - 0.15 11.0 10.7 0.18 10.8 10.7 1.2 1 0 0 1 1 1 0 CLN3 protein DUF4746 PF15928.5 CDI75967.1 - 0.15 11.4 7.2 0.17 11.3 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Cellulose_synt PF03552.14 CDI75967.1 - 0.18 10.2 5.0 0.19 10.2 5.0 1.0 1 0 0 1 1 1 0 Cellulose synthase DUF5308 PF17233.2 CDI75967.1 - 0.2 11.9 14.1 0.32 11.2 14.1 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF5308) PRP1_N PF06424.12 CDI75967.1 - 0.24 11.8 9.9 0.3 11.5 9.9 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal CD20 PF04103.15 CDI75967.1 - 0.25 11.4 1.3 0.45 10.6 1.3 1.3 1 0 0 1 1 1 0 CD20-like family Zip PF02535.22 CDI75967.1 - 0.31 10.2 4.7 0.35 10.0 4.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DDHD PF02862.17 CDI75967.1 - 0.37 10.9 9.2 0.45 10.6 9.2 1.2 1 0 0 1 1 1 0 DDHD domain SLC12 PF03522.15 CDI75967.1 - 0.41 9.6 15.0 0.47 9.4 15.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Ureide_permease PF07168.11 CDI75967.1 - 0.45 9.2 5.0 0.54 9.0 5.0 1.1 1 0 0 1 1 1 0 Ureide permease BORG_CEP PF14957.6 CDI75967.1 - 0.48 11.6 7.5 0.62 11.2 7.5 1.3 1 0 0 1 1 1 0 Cdc42 effector PPL5 PF18168.1 CDI75967.1 - 0.5 9.6 9.2 0.64 9.3 9.2 1.1 1 0 0 1 1 1 0 Prim-pol family 5 FAM76 PF16046.5 CDI75967.1 - 0.52 9.6 15.1 0.62 9.4 15.1 1.1 1 0 0 1 1 1 0 FAM76 protein MDM10 PF12519.8 CDI75967.1 - 0.53 9.1 12.2 0.6 8.9 12.2 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 BNR_3 PF13859.6 CDI75967.1 - 0.53 9.5 5.6 0.61 9.3 5.6 1.1 1 0 0 1 1 1 0 BNR repeat-like domain Hid1 PF12722.7 CDI75967.1 - 0.57 8.3 14.5 0.67 8.0 14.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4050 PF13259.6 CDI75967.1 - 0.74 10.1 11.0 0.9 9.8 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) DDRGK PF09756.9 CDI75967.1 - 1 8.9 21.0 1.5 8.3 21.0 1.2 1 0 0 1 1 1 0 DDRGK domain Gti1_Pac2 PF09729.9 CDI75967.1 - 1.1 9.3 11.1 1.3 9.1 11.1 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family FAM60A PF15396.6 CDI75967.1 - 1.4 8.9 9.4 1.8 8.6 9.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Kei1 PF08552.11 CDI75967.1 - 1.5 8.6 8.2 2.3 8.1 8.2 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 CPSF100_C PF13299.6 CDI75967.1 - 1.6 8.9 10.3 2 8.6 10.3 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Serinc PF03348.15 CDI75967.1 - 1.9 7.3 9.2 2.5 7.0 9.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) PepSY_TM PF03929.16 CDI75967.1 - 2.2 7.9 6.5 2.6 7.7 6.5 1.2 1 0 0 1 1 1 0 PepSY-associated TM region VIT1 PF01988.19 CDI75967.1 - 3.2 7.6 9.5 4.2 7.2 9.5 1.3 1 0 0 1 1 1 0 VIT family OATP PF03137.20 CDI75967.1 - 3.2 5.9 5.9 3.3 5.9 5.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4647 PF15504.6 CDI75967.1 - 3.7 6.6 19.6 4.4 6.3 19.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) PAT1 PF09770.9 CDI75967.1 - 4.2 5.5 31.5 5 5.3 31.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Cyto_heme_lyase PF01265.17 CDI75967.1 - 5.2 6.6 16.4 6.8 6.2 16.4 1.1 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase PRC2_HTH_1 PF18118.1 CDI75967.1 - 5.2 7.9 11.8 8 7.3 11.8 1.4 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Paramyxo_ncap PF00973.19 CDI75967.1 - 6 5.7 11.6 6.3 5.6 11.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein CDK5_activator PF03261.15 CDI75967.1 - 6.4 6.2 16.7 7.7 5.9 16.7 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein eIF-3_zeta PF05091.12 CDI75967.1 - 6.5 5.6 17.9 8 5.3 17.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Gastrin PF00918.17 CDI75967.1 - 8.3 7.4 20.7 0.13 13.2 10.1 2.0 1 1 1 2 2 2 0 Gastrin/cholecystokinin family DUF1754 PF08555.10 CDI75967.1 - 8.5 7.3 19.0 1.2 10.0 15.3 1.5 2 0 0 2 2 1 0 Eukaryotic family of unknown function (DUF1754) ALMT PF11744.8 CDI75967.1 - 9 5.0 14.4 10 4.8 14.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Ldh_1_N PF00056.23 CDI75968.1 - 1.4e-24 86.8 0.9 8.9e-24 84.2 0.1 2.2 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CDI75968.1 - 1.5e-23 83.6 0.1 1.5e-23 83.6 0.1 2.3 2 1 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Mucin PF01456.17 CDI75968.1 - 0.0041 17.1 9.6 0.0059 16.6 9.6 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein FAM199X PF15814.5 CDI75968.1 - 0.0061 15.7 3.0 0.0089 15.1 3.0 1.2 1 0 0 1 1 1 1 Protein family FAM199X NAD_binding_8 PF13450.6 CDI75968.1 - 0.033 14.4 0.0 0.1 12.8 0.0 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Rib_recp_KP_reg PF05104.12 CDI75968.1 - 0.038 15.0 11.9 0.061 14.4 11.9 1.2 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region DSHCT PF08148.12 CDI75968.1 - 0.05 13.3 1.1 0.086 12.5 0.0 1.8 2 1 0 2 2 2 0 DSHCT (NUC185) domain FSA_C PF10479.9 CDI75968.1 - 0.22 9.6 9.6 0.3 9.2 9.6 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus AIF-MLS PF14962.6 CDI75968.1 - 0.41 10.6 13.9 0.64 10.0 13.9 1.2 1 0 0 1 1 1 0 Mitochondria Localisation Sequence CCDC53 PF10152.9 CDI75968.1 - 3.6 8.0 8.4 6.2 7.2 8.4 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF4079 PF13301.6 CDI75970.1 - 8.1e-05 22.8 0.0 11 6.1 0.0 5.8 5 1 0 5 5 5 2 Protein of unknown function (DUF4079) K_channel_TID PF07941.11 CDI75970.1 - 0.0058 17.1 13.4 0.0058 17.1 13.4 21.0 13 7 7 20 20 20 4 Potassium channel Kv1.4 tandem inactivation domain SDA1 PF05285.12 CDI75972.1 - 0.5 9.8 12.2 0.58 9.5 12.2 1.1 1 0 0 1 1 1 0 SDA1 RskA PF10099.9 CDI75973.1 - 5.9e-07 30.0 8.2 5.9e-07 30.0 8.2 4.6 3 1 1 4 4 4 2 Anti-sigma-K factor rskA SARAF PF06682.12 CDI75973.1 - 0.014 15.1 2.2 0.014 15.1 2.2 5.8 2 2 2 6 6 6 0 SOCE-associated regulatory factor of calcium homoeostasis zf-RanBP PF00641.18 CDI75973.1 - 0.037 13.4 0.8 0.037 13.4 0.8 2.4 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others PAP2 PF01569.21 CDI75975.1 - 0.00035 20.4 0.4 0.00054 19.7 0.4 1.4 1 0 0 1 1 1 1 PAP2 superfamily Spt20 PF12090.8 CDI75975.1 - 0.005 16.5 19.0 0.0056 16.3 19.0 1.1 1 0 0 1 1 1 1 Spt20 family Pex14_N PF04695.13 CDI75975.1 - 0.0085 16.8 13.4 0.0085 16.8 13.4 2.1 1 1 1 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 CDI75975.1 - 0.48 10.4 22.1 0.71 9.8 22.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Mitofilin PF09731.9 CDI75975.1 - 0.73 8.6 25.9 0.81 8.5 25.9 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Roughex PF06020.11 CDI75975.1 - 1.1 8.3 11.7 1.1 8.2 11.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein NST1 PF13945.6 CDI75975.1 - 2.6 8.1 10.9 3.4 7.7 10.9 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Sin_N PF04801.13 CDI75975.1 - 2.9 7.0 12.0 3.3 6.8 12.0 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region PAP1 PF08601.10 CDI75975.1 - 3.3 7.3 17.5 3.8 7.1 17.5 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 RLL PF10036.9 CDI75975.1 - 5.3 6.8 15.9 6.4 6.5 15.9 1.0 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein DUF702 PF05142.12 CDI75975.1 - 5.4 7.5 11.5 7.6 7.0 11.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) GPCR_chapero_1 PF11904.8 CDI75976.1 - 7 6.0 23.2 9.7 5.5 23.2 1.2 1 0 0 1 1 1 0 GPCR-chaperone SR-25 PF10500.9 CDI75977.1 - 0.28 10.8 59.3 0.19 11.3 24.3 2.0 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI75977.1 - 3.5 7.9 37.7 94 3.2 9.7 2.6 1 1 1 2 2 2 0 Anti-sigma-K factor rskA GDI PF00996.18 CDI75979.1 - 7.5e-36 123.6 0.1 3.3e-22 78.6 0.0 2.2 2 0 0 2 2 2 2 GDP dissociation inhibitor DUF5308 PF17233.2 CDI75979.1 - 0.0036 17.5 9.4 0.0036 17.5 9.4 2.2 1 1 1 2 2 2 1 Family of unknown function (DUF5308) Caldesmon PF02029.15 CDI75979.1 - 0.0037 16.1 25.9 0.0044 15.9 25.9 1.0 1 0 0 1 1 1 1 Caldesmon PNISR PF15996.5 CDI75979.1 - 0.03 14.6 33.3 0.039 14.2 33.3 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR GREB1 PF15782.5 CDI75979.1 - 0.046 10.9 32.5 0.058 10.5 32.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LAP1C PF05609.12 CDI75979.1 - 0.11 11.6 28.9 0.16 11.1 28.9 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) WTX PF09422.10 CDI75979.1 - 0.15 11.1 18.8 0.21 10.7 18.8 1.1 1 0 0 1 1 1 0 WTX protein Dapper PF15268.6 CDI75979.1 - 0.33 9.7 36.3 0.39 9.5 36.3 1.0 1 0 0 1 1 1 0 Dapper EMC3_TMCO1 PF01956.16 CDI75979.1 - 0.38 10.5 28.8 0.13 12.0 10.3 2.4 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DUF5523 PF17661.1 CDI75979.1 - 0.44 10.2 35.9 0.6 9.8 35.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) BPL_N PF09825.9 CDI75979.1 - 0.56 9.2 21.6 0.9 8.5 21.6 1.3 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF966 PF06136.13 CDI75979.1 - 0.89 9.2 25.0 1.2 8.8 25.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) GramPos_pilinD1 PF16555.5 CDI75979.1 - 1.3 9.2 17.2 0.035 14.3 2.1 2.2 2 0 0 2 2 2 0 Gram-positive pilin subunit D1, N-terminal domain CAML PF14963.6 CDI75979.1 - 1.5 8.9 9.4 1.8 8.6 9.4 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand DUF4551 PF15087.6 CDI75979.1 - 2.9 6.6 31.0 3.9 6.2 31.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF572 PF04502.13 CDI75979.1 - 3.6 7.1 29.3 4.7 6.8 29.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SAPS PF04499.15 CDI75979.1 - 4.3 6.0 27.9 5.7 5.6 27.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Hid1 PF12722.7 CDI75979.1 - 5.2 5.1 38.0 6.5 4.7 38.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ACDC PF14733.6 CDI75981.1 - 5.1e-17 62.0 0.0 5.1e-17 62.0 0.0 3.7 2 0 0 2 2 2 1 AP2-coincident C-terminal Spt20 PF12090.8 CDI75983.1 - 0.0081 15.8 5.8 0.0081 15.8 5.8 13.8 2 1 5 7 7 7 1 Spt20 family HSP70 PF00012.20 CDI75984.1 - 1.6e-12 46.5 1.8 1.6e-12 46.5 1.8 6.4 2 1 3 5 5 5 1 Hsp70 protein SR-25 PF10500.9 CDI75984.1 - 0.0038 16.9 16.3 0.0038 16.9 16.3 4.8 4 0 0 4 4 4 2 Nuclear RNA-splicing-associated protein Androgen_recep PF02166.16 CDI75985.1 - 0.0094 14.8 11.6 0.0094 14.8 11.6 6.6 3 1 2 6 6 6 2 Androgen receptor SUIM_assoc PF16619.5 CDI75985.1 - 0.048 13.7 49.9 0.028 14.5 6.2 3.8 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF2339 PF10101.9 CDI75987.1 - 0.0012 17.5 14.6 0.0012 17.5 14.6 4.1 2 1 1 3 3 3 1 Predicted membrane protein (DUF2339) RskA PF10099.9 CDI75987.1 - 0.0028 18.0 4.0 0.0028 18.0 4.0 16.2 7 6 5 14 14 14 4 Anti-sigma-K factor rskA DUF2052 PF09747.9 CDI75987.1 - 0.0078 16.4 0.5 0.0078 16.4 0.5 7.3 6 2 1 7 7 7 1 Coiled-coil domain containing protein (DUF2052) TMEM247 PF15444.6 CDI75987.1 - 0.019 15.0 0.4 0.019 15.0 0.4 9.4 9 1 1 10 10 10 0 Transmembrane protein 247 Chorein_N PF12624.7 CDI75988.1 - 0.00081 19.5 0.9 0.00081 19.5 0.9 13.3 13 1 0 13 13 13 1 N-terminal region of Chorein or VPS13 RskA PF10099.9 CDI75988.1 - 0.0069 16.7 0.1 0.0069 16.7 0.1 25.1 6 6 10 17 17 17 4 Anti-sigma-K factor rskA Utp14 PF04615.13 CDI75988.1 - 0.0075 14.9 0.1 0.0075 14.9 0.1 10.5 5 2 3 10 10 10 2 Utp14 protein CNDH2_M PF16869.5 CDI75988.1 - 0.44 11.2 0.0 0.44 11.2 0.0 18.4 14 6 3 17 17 17 0 PF16858 EIF4E-T PF10477.9 CDI75989.1 - 0.0002 20.4 10.3 0.0002 20.4 10.3 2.0 2 0 0 2 2 2 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E BAF1_ABF1 PF04684.13 CDI75989.1 - 0.7 8.9 34.9 1.7 7.6 17.3 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor DUF4551 PF15087.6 CDI75989.1 - 2.7 6.7 40.3 1.1 7.9 7.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4551) SRP-alpha_N PF04086.13 CDI75989.1 - 3.9 7.3 37.7 1.4 8.7 8.0 2.2 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal RPN2_C PF18004.1 CDI75989.1 - 5 7.0 39.6 1.7 8.5 14.6 3.2 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN2 C-terminal domain RLL PF10036.9 CDI75989.1 - 6.5 6.5 48.8 0.77 9.6 17.8 3.2 3 0 0 3 3 3 0 RNA transcription, translation and transport factor protein Hamartin PF04388.12 CDI75989.1 - 8.7 4.9 38.2 12 4.4 38.2 1.2 1 0 0 1 1 1 0 Hamartin protein DUF2722 PF10846.8 CDI75991.1 - 8.5e-06 25.0 3.5 8.5e-06 25.0 3.5 3.2 2 1 1 3 3 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI75991.1 - 0.011 15.3 18.1 0.011 15.3 18.1 2.5 2 0 0 2 2 2 0 Spt20 family Suf PF05843.14 CDI75991.1 - 0.11 12.4 37.2 0.18 11.8 20.9 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) MAT1 PF06391.13 CDI75991.1 - 0.23 11.3 36.7 0.14 12.0 5.4 2.3 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 eIF-3_zeta PF05091.12 CDI75991.1 - 0.57 9.1 39.9 1.1 8.2 26.5 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF5523 PF17661.1 CDI75991.1 - 0.83 9.3 26.6 2.5 7.7 17.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) MMR1 PF08505.10 CDI75991.1 - 2 8.6 37.7 0.22 11.8 2.2 2.4 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein TFB6 PF17110.5 CDI75991.1 - 2.1 8.1 16.4 2.2 8.0 0.3 2.3 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH O-antigen_lig PF13425.6 CDI75991.1 - 3.1 6.5 10.5 0.55 9.0 3.8 2.1 2 0 0 2 2 2 0 O-antigen ligase like membrane protein Endostatin PF06482.11 CDI75991.1 - 3.2 7.1 31.1 4.1 6.8 2.2 2.2 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Dynamin_N PF00350.23 CDI75991.1 - 7.2 6.6 12.3 3.6 7.6 4.7 2.3 2 0 0 2 2 2 0 Dynamin family Gti1_Pac2 PF09729.9 CDI75991.1 - 9.7 6.2 29.0 1.5 8.9 0.5 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family rve PF00665.26 CDI75992.1 - 6.2e-09 36.1 0.0 1e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CDI75992.1 - 4.1e-07 29.8 0.0 0.026 14.4 0.0 2.6 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDI75992.1 - 0.069 12.9 0.2 0.14 11.9 0.2 1.5 1 0 0 1 1 1 0 Integrase core domain SecM PF06558.12 CDI75992.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Secretion monitor precursor protein (SecM) AAA_23 PF13476.6 CDI75993.1 - 0.0087 16.6 9.2 0.0087 16.6 9.2 4.6 3 2 0 3 3 3 1 AAA domain TFIIA PF03153.13 CDI75996.1 - 0.62 10.0 15.2 0.98 9.3 15.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI75996.1 - 2.8 7.5 20.2 4.2 6.9 20.2 1.2 1 0 0 1 1 1 0 Spt20 family UPF0560 PF10577.9 CDI75996.1 - 3.3 6.1 8.5 4.6 5.6 8.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Presenilin PF01080.17 CDI75996.1 - 4.3 6.0 4.3 5.9 5.5 4.3 1.1 1 0 0 1 1 1 0 Presenilin CLAG PF03805.13 CDI75997.1 - 0.0017 16.0 0.0 0.0043 14.7 0.0 1.5 1 1 0 1 1 1 1 Cytoadherence-linked asexual protein Myc_target_1 PF15179.6 CDI75999.1 - 0.035 14.0 1.0 0.063 13.2 1.0 1.3 1 0 0 1 1 1 0 Myc target protein 1 Presenilin PF01080.17 CDI75999.1 - 0.41 9.3 0.5 0.39 9.4 0.5 1.1 1 0 0 1 1 1 0 Presenilin Activator_LAG-3 PF11498.8 CDI76000.1 - 6.1e-05 22.2 8.3 6.1e-05 22.2 8.3 4.3 4 0 0 4 4 4 2 Transcriptional activator LAG-3 WBP-1 PF11669.8 CDI76000.1 - 0.0083 16.7 2.2 0.0083 16.7 2.2 4.1 4 0 0 4 4 4 2 WW domain-binding protein 1 CD20 PF04103.15 CDI76000.1 - 0.013 15.6 7.1 4.3 7.4 0.0 3.8 4 0 0 4 4 4 0 CD20-like family EphA2_TM PF14575.6 CDI76000.1 - 0.03 15.2 14.4 0.57 11.1 0.5 4.0 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain Spt20 PF12090.8 CDI76000.1 - 0.15 11.7 63.9 0.31 10.6 7.3 4.2 4 0 0 4 4 4 0 Spt20 family DUF2140 PF09911.9 CDI76000.1 - 0.45 10.0 10.5 3.5 7.1 0.2 3.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2140) RSN1_TM PF13967.6 CDI76000.1 - 0.7 9.6 0.0 0.7 9.6 0.0 2.1 3 0 0 3 3 3 0 Late exocytosis, associated with Golgi transport TMEM164 PF14808.6 CDI76000.1 - 2.4 7.4 8.1 9.3 5.5 0.5 3.1 3 0 0 3 3 3 0 TMEM164 family DUF4834 PF16118.5 CDI76000.1 - 3.1 8.8 24.5 1.6 9.7 2.7 4.7 4 1 0 4 4 4 0 Domain of unknown function (DUF4834) 7tm_1 PF00001.21 CDI76000.1 - 4.1 6.7 8.5 79 2.4 8.5 2.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) CDC27 PF09507.10 CDI76001.1 - 0.09 12.1 28.9 0.11 11.9 28.9 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Miga PF10265.9 CDI76001.1 - 0.17 10.9 6.6 0.17 10.8 6.6 1.2 1 0 0 1 1 1 0 Mitoguardin Ndc1_Nup PF09531.10 CDI76001.1 - 0.5 9.0 9.8 0.46 9.1 9.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hamartin PF04388.12 CDI76001.1 - 0.79 8.3 14.9 1.1 7.9 14.9 1.2 1 0 0 1 1 1 0 Hamartin protein CytochromB561_N PF09786.9 CDI76001.1 - 1.7 7.6 13.7 1.9 7.4 13.7 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal SOG2 PF10428.9 CDI76001.1 - 2 7.5 18.5 2.4 7.2 18.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein ANAPC1 PF12859.7 CDI76001.1 - 2.1 8.9 10.8 2.7 8.6 10.8 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 AF-4 PF05110.13 CDI76001.1 - 4.1 5.4 40.4 5 5.1 40.4 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein YbgS PF13985.6 CDI76001.1 - 4.6 7.5 18.7 8.4 6.7 18.7 1.4 1 0 0 1 1 1 0 YbgS-like protein Peptidase_S64 PF08192.11 CDI76001.1 - 5.1 5.5 15.7 6.3 5.1 15.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 Aminotran_5 PF00266.19 CDI76002.1 - 3.7e-29 101.8 0.0 2.9e-14 52.8 0.1 2.1 1 1 1 2 2 2 2 Aminotransferase class-V DUF2722 PF10846.8 CDI76002.1 - 4.9e-05 22.5 1.3 5.6e-05 22.3 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI76002.1 - 0.00095 18.8 9.0 0.0014 18.3 9.0 1.2 1 0 0 1 1 1 1 Spt20 family RAB3GAP2_N PF14655.6 CDI76002.1 - 0.055 12.7 2.8 0.077 12.2 2.8 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Pex14_N PF04695.13 CDI76002.1 - 0.057 14.1 0.6 0.057 14.1 0.6 3.0 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ETRAMP PF09716.10 CDI76002.1 - 0.23 11.5 0.0 0.23 11.5 0.0 4.2 2 2 2 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) TGT PF01702.18 CDI76003.1 - 2.3e-10 40.2 0.5 9.7e-10 38.1 0.6 2.0 2 0 0 2 2 2 1 Queuine tRNA-ribosyltransferase Ribosomal_60s PF00428.19 CDI76003.1 - 0.0093 16.5 7.7 0.0093 16.5 7.7 9.1 8 2 1 9 9 9 4 60s Acidic ribosomal protein Ecl1 PF12855.7 CDI76003.1 - 0.011 16.9 12.2 0.011 16.9 12.2 6.5 5 2 1 6 6 6 0 ECL1/2/3 zinc binding proteins CNDH2_M PF16869.5 CDI76003.1 - 0.41 11.3 0.1 0.41 11.3 0.1 7.8 5 1 2 7 7 7 0 PF16858 Asparaginase_2 PF01112.18 CDI76004.1 - 0.0088 15.1 2.1 0.011 14.7 2.1 1.3 1 0 0 1 1 1 1 Asparaginase Tim54 PF11711.8 CDI76004.1 - 0.26 10.1 11.2 0.33 9.7 11.2 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4746 PF15928.5 CDI76004.1 - 0.67 9.3 9.8 0.72 9.2 9.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CLN3 PF02487.17 CDI76004.1 - 0.73 8.8 10.2 0.88 8.6 10.2 1.2 1 0 0 1 1 1 0 CLN3 protein PepSY_TM PF03929.16 CDI76004.1 - 1 8.9 8.8 1.2 8.8 8.8 1.2 1 0 0 1 1 1 0 PepSY-associated TM region V_ATPase_I PF01496.19 CDI76004.1 - 1.4 6.8 16.3 1.9 6.3 16.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MPM1 PF17234.2 CDI76004.1 - 1.4 9.1 19.0 0.068 13.4 12.5 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Peroxin-13_N PF04088.13 CDI76004.1 - 1.7 8.9 11.4 0.18 12.1 7.2 1.6 2 0 0 2 2 2 0 Peroxin 13, N-terminal region CDC45 PF02724.14 CDI76004.1 - 1.9 6.7 18.1 2 6.6 18.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2828 PF11443.8 CDI76004.1 - 2.3 6.2 16.1 3 5.8 16.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Baculo_PP31 PF05311.11 CDI76004.1 - 2.4 7.6 14.0 3.8 6.9 14.0 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) SLC12 PF03522.15 CDI76004.1 - 3.2 6.7 20.6 3.7 6.5 20.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Zip PF02535.22 CDI76004.1 - 4 6.5 9.1 4.3 6.5 9.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Folate_carrier PF01770.18 CDI76004.1 - 4.1 6.0 6.8 4.7 5.8 6.8 1.2 1 0 0 1 1 1 0 Reduced folate carrier HCO3_cotransp PF00955.21 CDI76004.1 - 4.1 6.1 5.9 4.6 5.9 5.9 1.1 1 0 0 1 1 1 0 HCO3- transporter family Otopetrin PF03189.13 CDI76004.1 - 4.6 6.0 9.2 4.7 5.9 9.2 1.2 1 0 0 1 1 1 0 Otopetrin AAA_23 PF13476.6 CDI76004.1 - 5.1 7.5 26.8 7.3 7.0 26.8 1.3 1 0 0 1 1 1 0 AAA domain EPOP PF15223.6 CDI76004.1 - 5.9 6.1 19.5 7.4 5.8 19.5 1.1 1 0 0 1 1 1 0 Elongin BC and Polycomb repressive complex 2-associated protein CCDC53 PF10152.9 CDI76004.1 - 6.2 7.2 19.1 0.78 10.1 14.9 1.6 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex RR_TM4-6 PF06459.12 CDI76004.1 - 6.5 6.5 19.5 0.99 9.2 15.9 1.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 CDI76004.1 - 7.1 5.3 14.9 7.1 5.3 14.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4175 PF13779.6 CDI76004.1 - 8.2 4.2 54.1 10 3.9 54.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Membralin PF09746.9 CDI76004.1 - 8.9 5.2 11.4 9.1 5.2 11.4 1.1 1 0 0 1 1 1 0 Tumour-associated protein AAA_assoc_2 PF16193.5 CDI76005.1 - 0.00011 22.4 0.0 0.00017 21.8 0.0 1.3 1 0 0 1 1 1 1 AAA C-terminal domain DNA_pol3_delta PF06144.13 CDI76005.1 - 0.022 14.5 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit SPX PF03105.19 CDI76006.1 - 0.00084 19.4 21.7 0.0012 18.9 21.7 1.2 1 0 0 1 1 1 1 SPX domain SR-25 PF10500.9 CDI76006.1 - 0.0021 17.7 33.5 0.0021 17.7 33.5 2.0 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Lin-8 PF03353.15 CDI76006.1 - 0.27 10.7 36.2 0.41 10.1 36.2 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2151 PF10221.9 CDI76006.1 - 0.49 8.9 14.7 0.76 8.3 14.7 1.3 1 0 0 1 1 1 0 Cell cycle and development regulator Cellulose_synt PF03552.14 CDI76006.1 - 0.49 8.8 5.5 0.56 8.6 5.5 1.3 1 0 0 1 1 1 0 Cellulose synthase PI3K_1B_p101 PF10486.9 CDI76006.1 - 0.57 7.9 17.7 0.99 7.1 17.7 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF1635 PF07795.11 CDI76006.1 - 0.99 9.2 25.3 1.8 8.3 25.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) CNDH2_C PF16858.5 CDI76006.1 - 4.6 7.0 24.8 6.8 6.5 24.8 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SpoIIP PF07454.11 CDI76006.1 - 9.9 5.5 28.3 1.6 8.1 24.1 1.8 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) SpoIIIAH PF12685.7 CDI76007.1 - 0.012 15.5 3.1 0.015 15.1 3.1 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein SPX PF03105.19 CDI76007.1 - 0.012 15.6 11.1 0.012 15.6 11.1 1.1 1 0 0 1 1 1 0 SPX domain CCDC24 PF15669.5 CDI76007.1 - 0.052 13.4 6.2 0.061 13.2 6.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Ribosomal_60s PF00428.19 CDI76007.1 - 0.059 14.0 9.3 0.11 13.1 9.3 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Pex14_N PF04695.13 CDI76007.1 - 3.7 8.2 10.7 5.8 7.6 6.0 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Apt1 PF10351.9 CDI76007.1 - 4.1 6.2 16.8 5.1 5.8 16.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain RskA PF10099.9 CDI76008.1 - 0.003 17.9 42.2 0.046 14.0 12.1 3.3 3 0 0 3 3 3 3 Anti-sigma-K factor rskA DUF755 PF05501.11 CDI76009.1 - 0.00079 19.7 17.8 0.00079 19.7 17.8 7.0 6 1 1 7 7 7 1 Domain of unknown function (DUF755) SR-25 PF10500.9 CDI76009.1 - 0.00084 19.0 7.6 0.00084 19.0 7.6 5.5 6 0 0 6 6 6 3 Nuclear RNA-splicing-associated protein Orf78 PF06024.12 CDI76009.1 - 0.016 15.5 3.7 0.016 15.5 3.7 6.9 4 2 1 6 6 6 0 Orf78 (ac78) Csm4_C PF17953.1 CDI76009.1 - 1.4 8.8 4.7 31 4.5 0.1 3.3 3 0 0 3 3 3 0 CRISPR Csm4 C-terminal domain DUF4551 PF15087.6 CDI76010.1 - 9.1 5.0 42.7 10 4.8 42.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Ribosomal_60s PF00428.19 CDI76011.1 - 5.8 7.6 17.5 2.5 8.7 7.6 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3381 PF11861.8 CDI76012.1 - 0.13 12.0 0.1 0.13 12.0 0.1 6.9 4 2 2 6 6 6 0 Domain of unknown function (DUF3381) eIF-3c_N PF05470.12 CDI76012.1 - 0.23 9.7 0.0 0.23 9.7 0.0 4.0 2 2 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Thioredoxin_14 PF18402.1 CDI76014.1 - 0.2 11.6 9.8 0.42 10.5 9.8 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain DUF2339 PF10101.9 CDI76014.1 - 0.54 8.8 32.2 1.5 7.3 32.2 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2339) DUF4457 PF14652.6 CDI76014.1 - 1.1 8.5 4.9 1.8 7.8 4.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) Ydr279_N PF17745.1 CDI76015.1 - 0.19 12.0 3.6 0.41 10.9 3.6 1.6 1 0 0 1 1 1 0 Ydr279p protein triple barrel domain SRP-alpha_N PF04086.13 CDI76015.1 - 2.9 7.7 31.3 4.2 7.2 31.3 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Presenilin PF01080.17 CDI76017.1 - 4.7 5.9 35.1 5.5 5.6 35.1 1.1 1 0 0 1 1 1 0 Presenilin AbLIM_anchor PF16182.5 CDI76017.1 - 9.2 6.0 24.6 12 5.6 24.6 1.1 1 0 0 1 1 1 0 Putative adherens-junction anchoring region of AbLIM SUIM_assoc PF16619.5 CDI76018.1 - 0.00015 21.8 1.5 0.00015 21.8 1.5 2.0 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI76018.1 - 0.021 14.4 7.4 0.029 14.0 7.4 1.2 1 0 0 1 1 1 0 Spt20 family Sporozoite_P67 PF05642.11 CDI76018.1 - 0.039 12.0 0.3 0.057 11.5 0.3 1.4 1 1 0 1 1 1 0 Sporozoite P67 surface antigen Roughex PF06020.11 CDI76018.1 - 3.1 6.8 6.8 0.61 9.1 2.1 2.0 2 0 0 2 2 2 0 Drosophila roughex protein DUF4366 PF14283.6 CDI76020.1 - 0.53 10.3 6.2 0.6 10.1 6.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) RskA PF10099.9 CDI76022.1 - 0.0024 18.2 13.6 0.0024 18.2 13.6 3.2 1 1 2 3 3 3 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI76022.1 - 0.017 15.2 46.1 0.022 14.8 46.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_23 PF13476.6 CDI76022.1 - 0.13 12.8 14.0 0.15 12.5 14.0 1.2 1 0 0 1 1 1 0 AAA domain DUF4770 PF15994.5 CDI76022.1 - 2.3 8.4 15.3 4 7.6 15.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF4834 PF16118.5 CDI76022.1 - 7.6 7.6 20.6 0.42 11.6 13.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) OATP PF03137.20 CDI76022.1 - 9.9 4.3 8.2 16 3.6 8.2 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Spt20 PF12090.8 CDI76032.1 - 0.00052 19.7 19.8 0.00052 19.7 19.8 2.3 2 0 0 2 2 2 1 Spt20 family TMEM51 PF15345.6 CDI76032.1 - 0.0013 18.6 27.1 0.016 15.0 7.4 2.3 2 0 0 2 2 2 2 Transmembrane protein 51 EPL1 PF10513.9 CDI76032.1 - 0.0028 18.1 21.7 0.19 12.1 6.5 2.4 2 0 0 2 2 2 2 Enhancer of polycomb-like CobT PF06213.12 CDI76032.1 - 0.015 14.7 32.7 0.28 10.5 13.6 2.4 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF572 PF04502.13 CDI76032.1 - 0.024 14.2 26.0 0.032 13.8 26.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF2052 PF09747.9 CDI76032.1 - 0.035 14.2 28.1 0.47 10.6 7.4 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Rad54_N PF08658.10 CDI76032.1 - 0.05 13.8 20.3 0.12 12.5 4.8 2.5 2 1 0 2 2 2 0 Rad54 N terminal Isy1 PF06246.12 CDI76032.1 - 0.063 12.8 28.8 0.37 10.3 8.5 2.1 2 0 0 2 2 2 0 Isy1-like splicing family TERB2 PF15101.6 CDI76032.1 - 0.08 13.0 36.5 0.23 11.5 11.7 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 CNDH2_C PF16858.5 CDI76032.1 - 0.088 12.7 27.0 0.57 10.0 11.8 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term MecA PF05389.12 CDI76032.1 - 0.095 12.3 22.5 0.47 10.1 8.6 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF4770 PF15994.5 CDI76032.1 - 0.1 12.8 26.2 0.27 11.4 6.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) LMBR1 PF04791.16 CDI76032.1 - 0.12 11.2 13.7 0.19 10.6 13.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4776 PF16003.5 CDI76032.1 - 0.13 11.2 23.3 0.22 10.5 5.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) SpoIIP PF07454.11 CDI76032.1 - 0.14 11.6 26.3 0.56 9.6 9.2 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Thg1C PF14413.6 CDI76032.1 - 0.2 11.8 24.6 0.059 13.5 8.5 2.3 2 0 0 2 2 2 0 Thg1 C terminal domain Presenilin PF01080.17 CDI76032.1 - 0.27 10.0 31.4 0.91 8.2 11.7 2.1 2 0 0 2 2 2 0 Presenilin Rxt3 PF08642.10 CDI76032.1 - 0.28 12.0 17.3 0.26 12.1 3.5 2.3 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 DUF4179 PF13786.6 CDI76032.1 - 0.32 11.5 0.0 0.32 11.5 0.0 2.8 3 1 0 3 3 1 0 Domain of unknown function (DUF4179) MMR1 PF08505.10 CDI76032.1 - 0.36 11.1 37.2 0.26 11.5 13.2 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein MH2 PF03166.14 CDI76032.1 - 0.37 11.0 13.3 0.23 11.7 0.9 2.2 2 0 0 2 2 2 0 MH2 domain Pex14_N PF04695.13 CDI76032.1 - 0.4 11.3 54.2 0.039 14.6 12.9 3.1 2 1 1 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TRAP_alpha PF03896.16 CDI76032.1 - 0.41 9.8 16.5 1.5 7.9 5.0 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF3408 PF11888.8 CDI76032.1 - 0.44 10.7 24.1 1.3 9.2 5.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) MAT1 PF06391.13 CDI76032.1 - 0.49 10.2 41.0 0.5 10.2 11.9 2.1 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Endostatin PF06482.11 CDI76032.1 - 0.5 9.8 25.4 1.7 8.0 9.2 2.1 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Pinin_SDK_memA PF04696.13 CDI76032.1 - 0.52 10.4 48.8 1.3 9.0 16.3 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Tim54 PF11711.8 CDI76032.1 - 0.57 8.9 22.5 1.2 7.8 6.3 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 EOS1 PF12326.8 CDI76032.1 - 0.61 10.0 14.4 0.48 10.3 0.6 2.3 2 0 0 2 2 2 0 N-glycosylation protein Connexin PF00029.19 CDI76032.1 - 0.63 9.7 22.9 1.9 8.2 9.8 2.1 2 0 0 2 2 2 0 Connexin Endonuc_Holl PF10107.9 CDI76032.1 - 0.68 9.8 27.3 0.12 12.3 13.4 2.1 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase DUF5523 PF17661.1 CDI76032.1 - 0.69 9.6 28.3 1.3 8.6 8.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) DUF4746 PF15928.5 CDI76032.1 - 0.81 9.1 19.5 0.44 9.9 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) V_ATPase_I PF01496.19 CDI76032.1 - 0.93 7.3 26.4 1.2 6.9 6.8 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF4175 PF13779.6 CDI76032.1 - 1.2 7.0 54.4 0.12 10.2 16.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) ABC2_membrane_2 PF12679.7 CDI76032.1 - 1.3 8.3 10.6 0.79 9.0 1.7 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein PRP1_N PF06424.12 CDI76032.1 - 1.3 9.4 24.8 0.76 10.2 7.5 2.3 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal NARP1 PF12569.8 CDI76032.1 - 1.3 7.8 31.6 1.5 7.7 15.5 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 MAP65_ASE1 PF03999.12 CDI76032.1 - 1.4 7.6 30.1 0.22 10.2 8.9 2.1 2 0 0 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) FCP1_C PF09309.10 CDI76032.1 - 1.4 8.7 27.0 0.23 11.3 8.9 2.2 2 0 0 2 2 2 0 FCP1, C-terminal Serinc PF03348.15 CDI76032.1 - 1.5 7.7 16.5 1.2 7.9 1.5 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) CDC37_N PF03234.14 CDI76032.1 - 1.9 9.4 32.1 4.1 8.3 15.3 2.2 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding FAM76 PF16046.5 CDI76032.1 - 2 7.7 30.7 0.67 9.3 10.3 2.1 2 0 0 2 2 2 0 FAM76 protein DUF1644 PF07800.12 CDI76032.1 - 2 8.5 17.9 4.8 7.2 6.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) CPSF100_C PF13299.6 CDI76032.1 - 2 8.6 26.0 1.4 9.0 6.7 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Rrp15p PF07890.12 CDI76032.1 - 2.2 8.6 31.7 2.3 8.6 9.2 2.5 2 0 0 2 2 2 0 Rrp15p LAP1C PF05609.12 CDI76032.1 - 2.5 7.1 29.4 2.7 7.0 11.0 2.0 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) DUF913 PF06025.12 CDI76032.1 - 2.6 6.9 18.3 1.4 7.9 4.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) UPF0560 PF10577.9 CDI76032.1 - 3.3 6.1 41.2 3.2 6.1 12.2 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 D123 PF07065.14 CDI76032.1 - 3.6 6.7 23.3 1.6 7.8 9.6 2.1 2 0 0 2 2 2 0 D123 Bud13 PF09736.9 CDI76032.1 - 3.6 8.0 31.4 0.36 11.2 6.2 2.4 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex DUF4820 PF16091.5 CDI76032.1 - 3.7 6.9 23.4 3.5 6.9 8.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) PDCD7 PF16021.5 CDI76032.1 - 3.8 6.5 35.6 0.89 8.6 8.7 2.1 2 0 0 2 2 2 0 Programmed cell death protein 7 MPM1 PF17234.2 CDI76032.1 - 3.9 7.7 30.1 2 8.6 9.3 2.3 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Peptidase_C58 PF03543.14 CDI76032.1 - 3.9 7.1 27.8 2.2 7.9 8.9 2.2 2 0 0 2 2 2 0 Yersinia/Haemophilus virulence surface antigen PTPRCAP PF15713.5 CDI76032.1 - 4.8 7.5 32.8 2.4 8.4 8.8 2.4 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated RPA43_OB PF17875.1 CDI76032.1 - 5 7.8 18.8 3.1 8.4 3.9 2.4 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Slu7 PF11708.8 CDI76032.1 - 5.1 6.8 32.2 2.5 7.8 7.6 2.1 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor dsDNA_bind PF01984.20 CDI76032.1 - 5.3 7.4 53.3 4.3 7.7 22.3 2.7 2 0 0 2 2 2 0 Double-stranded DNA-binding domain Afi1 PF07792.12 CDI76032.1 - 5.4 7.5 26.1 5.1 7.6 7.3 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking eIF-3_zeta PF05091.12 CDI76032.1 - 5.5 5.8 38.4 1.8 7.4 12.5 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_S49_N PF08496.10 CDI76032.1 - 5.5 7.0 27.7 4.4 7.4 7.4 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal LicD PF04991.13 CDI76032.1 - 5.7 7.0 10.1 5.5 7.0 0.3 2.1 2 0 0 2 2 2 0 LicD family SLC12 PF03522.15 CDI76032.1 - 5.7 5.8 29.3 3.8 6.4 10.4 2.0 2 0 0 2 2 2 0 Solute carrier family 12 DUF5327 PF17261.2 CDI76032.1 - 6 7.7 39.4 3.1 8.6 11.9 2.9 3 0 0 3 3 2 0 Family of unknown function (DUF5327) MMM1 PF10296.9 CDI76032.1 - 6.9 5.6 19.9 2.9 6.9 5.5 2.1 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 DUF4471 PF14740.6 CDI76032.1 - 7 5.8 17.9 5.4 6.1 4.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) ORC5_C PF14630.6 CDI76032.1 - 7.1 6.0 17.8 3.9 6.9 3.2 2.3 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus DUF702 PF05142.12 CDI76032.1 - 7.9 7.0 27.4 5.5 7.5 7.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF702) G0-G1_switch_2 PF15103.6 CDI76032.1 - 7.9 7.0 22.8 12 6.4 6.8 2.6 2 0 0 2 2 2 0 G0/G1 switch protein 2 Tsg PF04668.12 CDI76032.1 - 8.2 7.1 16.5 3 8.5 5.5 2.3 2 0 0 2 2 2 0 Twisted gastrulation (Tsg) protein conserved region Lin-8 PF03353.15 CDI76032.1 - 9.4 5.7 43.1 3.1 7.3 15.4 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF3537 PF12056.8 CDI76032.1 - 9.4 4.9 11.5 0.75 8.5 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3537) eIF3_subunit PF08597.10 CDI76034.1 - 0.00015 21.8 13.6 0.00015 21.8 13.6 4.3 3 2 1 4 4 4 1 Translation initiation factor eIF3 subunit Coilin_N PF15862.5 CDI76034.1 - 0.13 12.1 0.0 0.13 12.1 0.0 7.4 6 3 0 6 6 6 0 Coilin N-terminus RskA PF10099.9 CDI76052.1 - 0.0002 21.7 3.4 0.0002 21.7 3.4 4.5 1 1 2 3 3 3 1 Anti-sigma-K factor rskA YceD PF02620.17 CDI76052.1 - 0.064 13.4 0.2 0.064 13.4 0.2 2.0 2 0 0 2 2 2 0 Large ribosomal RNA subunit accumulation protein YceD NTP_transf_4 PF13562.6 CDI76052.1 - 1.2 9.3 10.6 6.3 7.0 1.5 2.4 2 0 0 2 2 2 0 Sugar nucleotidyl transferase Mit_KHE1 PF10173.9 CDI76052.1 - 1.9 8.6 9.6 1.7 8.7 4.0 2.5 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related Spt20 PF12090.8 CDI76052.1 - 2.3 7.8 52.0 0.041 13.5 7.3 3.6 4 0 0 4 4 4 0 Spt20 family PE_PPE_C PF12484.8 CDI76052.1 - 4.1 8.4 45.1 5.1 8.1 7.6 3.8 3 0 0 3 3 3 0 Polymorphic PE/PPE proteins C terminal DUF4366 PF14283.6 CDI76066.1 - 0.016 15.2 5.8 0.016 15.2 5.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) DUF4281 PF14108.6 CDI76066.1 - 0.14 12.5 0.2 0.25 11.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4281) Gram_pos_anchor PF00746.21 CDI76066.1 - 1.4 8.9 3.4 2.6 8.1 3.4 1.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif DUF2722 PF10846.8 CDI76067.1 - 0.0037 16.3 13.8 0.0037 16.3 13.8 7.2 4 2 2 6 6 6 2 Protein of unknown function (DUF2722) Draxin PF15550.6 CDI76067.1 - 2 8.2 52.5 0.4 10.5 5.2 4.1 4 0 0 4 4 4 0 Draxin FAM60A PF15396.6 CDI76074.1 - 0.057 13.4 34.8 0.077 13.0 34.8 1.2 1 0 0 1 1 1 0 Protein Family FAM60A CDC45 PF02724.14 CDI76074.1 - 0.29 9.4 39.4 0.33 9.2 39.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI76074.1 - 0.43 9.3 52.4 0.51 9.0 52.4 1.1 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 CDI76074.1 - 3.3 6.4 35.1 3.6 6.3 35.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein AAA_11 PF13086.6 CDI76074.1 - 5.7 6.6 40.5 9.3 5.9 40.5 1.4 1 0 0 1 1 1 0 AAA domain DUF4045 PF13254.6 CDI76074.1 - 8.7 5.9 39.2 11 5.6 39.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF2052 PF09747.9 CDI76082.1 - 0.14 12.3 27.3 0.2 11.8 27.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Ribosomal_60s PF00428.19 CDI76082.1 - 0.47 11.1 58.6 0.15 12.7 34.2 2.1 1 1 1 2 2 2 0 60s Acidic ribosomal protein DNA_pol_phi PF04931.13 CDI76082.1 - 1.3 7.0 38.2 1.3 7.0 38.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Mpp10 PF04006.12 CDI76082.1 - 2.2 6.6 32.3 2.2 6.6 32.3 1.0 1 0 0 1 1 1 0 Mpp10 protein DUF2457 PF10446.9 CDI76082.1 - 3 6.9 36.9 3.4 6.7 36.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Paf1 PF03985.13 CDI76082.1 - 3.3 6.6 32.7 3.9 6.4 32.7 1.0 1 0 0 1 1 1 0 Paf1 Connexin PF00029.19 CDI76082.1 - 3.5 7.3 11.3 3.7 7.2 11.3 1.2 1 0 0 1 1 1 0 Connexin Nop25 PF09805.9 CDI76082.1 - 3.8 8.0 28.9 4.3 7.8 28.9 1.0 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Pex14_N PF04695.13 CDI76082.1 - 6.2 7.4 13.4 7.7 7.2 13.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SpoIIP PF07454.11 CDI76082.1 - 7.5 5.9 17.2 8.8 5.7 17.2 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Spore_III_AF PF09581.10 CDI76088.1 - 0.028 14.4 8.4 0.046 13.7 8.5 1.4 1 1 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) TFIIA PF03153.13 CDI76088.1 - 0.072 13.1 43.4 0.09 12.8 43.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Draxin PF15550.6 CDI76088.1 - 0.81 9.5 20.2 1.1 9.1 20.2 1.2 1 0 0 1 1 1 0 Draxin Mitofilin PF09731.9 CDI76088.1 - 2.7 6.7 38.2 3.2 6.5 38.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein SCAI PF12070.8 CDI76088.1 - 9.5 4.9 11.6 11 4.7 11.6 1.1 1 0 0 1 1 1 0 Protein SCAI SKIP_SNW PF02731.15 CDI76090.1 - 9.7e-17 61.1 7.3 9.7e-17 61.1 7.3 2.0 2 0 0 2 2 2 1 SKIP/SNW domain TALPID3 PF15324.6 CDI76090.1 - 7.8 4.0 10.5 9.5 3.7 10.5 1.0 1 0 0 1 1 1 0 Hedgehog signalling target Presenilin PF01080.17 CDI76090.1 - 8.2 5.1 5.9 9.8 4.8 5.9 1.1 1 0 0 1 1 1 0 Presenilin Abhydrolase_2 PF02230.16 CDI76091.1 - 3.9e-48 164.1 0.0 7.3e-48 163.2 0.0 1.4 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase SET PF00856.28 CDI76091.1 - 2e-07 31.6 0.0 0.03 14.7 0.0 2.7 2 0 0 2 2 2 2 SET domain Abhydrolase_6 PF12697.7 CDI76091.1 - 0.00065 20.4 0.1 0.00065 20.4 0.1 4.4 3 2 2 5 5 4 1 Alpha/beta hydrolase family Esterase_phd PF10503.9 CDI76091.1 - 0.0016 18.0 0.0 0.0016 18.0 0.0 3.6 4 0 0 4 4 3 1 Esterase PHB depolymerase Abhydrolase_3 PF07859.13 CDI76091.1 - 0.0047 16.8 0.0 0.024 14.5 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 CDI76091.1 - 0.0098 15.6 0.0 0.036 13.7 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CDI76091.1 - 0.015 14.8 0.1 0.62 9.5 0.0 2.4 2 0 0 2 2 2 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CDI76091.1 - 0.057 12.7 4.6 0.59 9.4 0.1 3.5 3 1 1 4 4 4 0 Serine aminopeptidase, S33 FSH1 PF03959.13 CDI76091.1 - 0.057 13.1 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DUF2920 PF11144.8 CDI76091.1 - 0.21 10.7 0.0 0.45 9.6 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2920) AXE1 PF05448.12 CDI76091.1 - 0.25 10.0 0.0 0.55 8.8 0.0 1.5 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) TPR_9 PF13371.6 CDI76093.1 - 1.1e-09 38.3 1.3 1.1e-09 38.3 1.3 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDI76093.1 - 8.9e-09 35.7 2.8 8.9e-09 35.7 2.8 2.1 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDI76093.1 - 4.2e-08 32.7 0.7 0.016 15.3 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDI76093.1 - 1.2e-07 31.3 0.4 0.002 17.9 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI76093.1 - 7.8e-05 23.2 0.7 7.8e-05 23.2 0.7 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDI76093.1 - 0.00017 22.0 2.2 0.002 18.6 0.3 3.4 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDI76093.1 - 0.00031 20.7 0.7 0.021 15.0 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDI76093.1 - 0.00038 21.1 1.2 0.00038 21.1 1.2 4.2 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDI76093.1 - 0.0013 19.0 0.2 0.0049 17.2 0.2 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI76093.1 - 0.0055 16.9 0.6 0.0055 16.9 0.6 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CDI76093.1 - 0.012 15.8 1.2 0.073 13.4 1.2 2.4 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_4 PF07721.14 CDI76093.1 - 0.021 15.4 0.3 0.021 15.4 0.3 4.2 5 0 0 5 5 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDI76093.1 - 0.026 14.6 0.3 11 6.2 0.0 2.8 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat bZIP_Maf PF03131.17 CDI76093.1 - 0.077 13.5 6.1 1.4 9.5 1.4 2.9 2 0 0 2 2 2 0 bZIP Maf transcription factor Pex19 PF04614.12 CDI76093.1 - 0.35 10.6 4.4 0.67 9.7 4.4 1.6 1 0 0 1 1 1 0 Pex19 protein family ORC5_C PF14630.6 CDI76094.1 - 0.015 14.8 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus IQ PF00612.27 CDI76096.1 - 0.07 13.0 0.2 0.15 11.9 0.2 1.6 1 0 0 1 1 1 0 IQ calmodulin-binding motif Med19 PF10278.9 CDI76110.1 - 0.0014 18.6 1.3 0.002 18.1 1.3 1.3 1 0 0 1 1 1 1 Mediator of RNA pol II transcription subunit 19 FHIPEP PF00771.20 CDI76110.1 - 0.023 13.2 4.7 0.024 13.1 4.7 1.2 1 0 0 1 1 1 0 FHIPEP family eIF-3_zeta PF05091.12 CDI76110.1 - 0.043 12.8 8.9 0.047 12.7 8.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI76110.1 - 0.047 13.7 36.7 0.053 13.5 36.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SID-1_RNA_chan PF13965.6 CDI76110.1 - 0.27 9.6 0.8 0.23 9.8 0.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Spt20 PF12090.8 CDI76110.1 - 0.28 10.7 35.9 0.43 10.1 35.9 1.3 1 0 0 1 1 1 0 Spt20 family PAT1 PF09770.9 CDI76110.1 - 0.47 8.7 19.9 0.45 8.7 19.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Serinc PF03348.15 CDI76110.1 - 0.73 8.7 3.0 0.66 8.8 3.0 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) EIIBC-GUT_N PF03612.14 CDI76110.1 - 0.76 9.5 7.8 1.2 8.9 7.8 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Connexin PF00029.19 CDI76110.1 - 0.9 9.2 5.6 1.3 8.7 5.6 1.2 1 0 0 1 1 1 0 Connexin Glt_symporter PF03616.14 CDI76110.1 - 1.1 7.8 3.8 0.87 8.2 2.7 1.3 1 1 0 1 1 1 0 Sodium/glutamate symporter SpoIIP PF07454.11 CDI76110.1 - 2.2 7.6 11.8 3 7.2 11.8 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) LMBR1 PF04791.16 CDI76110.1 - 2.4 7.0 4.7 2.2 7.1 4.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Ribosomal_60s PF00428.19 CDI76110.1 - 2.4 8.8 21.1 0.86 10.2 7.5 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein OATP PF03137.20 CDI76110.1 - 4.2 5.5 6.2 5.9 5.1 6.2 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CLN3 PF02487.17 CDI76110.1 - 4.7 6.2 7.5 7.4 5.5 7.5 1.4 1 0 0 1 1 1 0 CLN3 protein YABBY PF04690.13 CDI76110.1 - 7.2 7.2 10.4 0.63 10.6 4.4 2.0 2 0 0 2 2 2 0 YABBY protein FAM176 PF14851.6 CDI76110.1 - 7.8 6.2 8.4 4.3 7.0 6.1 1.7 2 0 0 2 2 2 0 FAM176 family Spt20 PF12090.8 CDI76111.1 - 0.0083 15.8 8.7 0.01 15.5 8.7 1.1 1 0 0 1 1 1 1 Spt20 family Ribosomal_60s PF00428.19 CDI76111.1 - 0.011 16.2 42.2 0.26 11.9 5.8 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein TFIIA PF03153.13 CDI76111.1 - 0.085 12.8 10.6 0.11 12.5 10.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF775 PF05603.12 CDI76111.1 - 0.091 12.3 4.8 0.13 11.8 4.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Methyltransf_34 PF11312.8 CDI76111.1 - 0.16 11.2 1.6 0.26 10.5 1.6 1.3 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase DUF2722 PF10846.8 CDI76111.1 - 0.18 10.7 5.5 0.23 10.4 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) UPF0565 PF10561.9 CDI76111.1 - 0.67 9.1 3.5 0.62 9.2 2.8 1.4 1 1 0 1 1 1 0 Uncharacterised protein family UPF0565 AF-4 PF05110.13 CDI76112.1 - 7.5e-05 21.0 9.8 8.6e-05 20.9 9.8 1.2 1 0 0 1 1 1 1 AF-4 proto-oncoprotein SR-25 PF10500.9 CDI76112.1 - 0.00055 19.6 5.4 0.00071 19.3 5.4 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein BSP_II PF05432.11 CDI76112.1 - 0.0012 18.6 0.9 0.0015 18.3 0.9 1.2 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Cwf_Cwc_15 PF04889.12 CDI76112.1 - 0.0019 18.0 0.4 0.0019 18.0 0.4 1.5 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein DUF4640 PF15480.6 CDI76112.1 - 0.01 15.7 3.4 0.014 15.2 3.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4640) 2_5_RNA_ligase2 PF13563.6 CDI76112.1 - 0.025 14.5 2.3 0.047 13.6 2.2 1.5 1 1 0 1 1 1 0 2'-5' RNA ligase superfamily POX PF07526.11 CDI76112.1 - 0.047 14.3 9.8 5.8 7.5 9.8 2.1 1 1 0 1 1 1 0 Associated with HOX Tmemb_9 PF05434.11 CDI76112.1 - 1.2 9.0 2.9 0.42 10.5 0.5 1.4 2 0 0 2 2 2 0 TMEM9 DUF4813 PF16072.5 CDI76112.1 - 3 7.4 18.7 4.2 6.9 18.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Tic110 PF16940.5 CDI76112.1 - 8.1 4.8 8.3 10 4.5 8.3 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter RskA PF10099.9 CDI76112.1 - 8.6 6.6 27.8 13 6.1 27.8 1.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA POP1 PF06978.11 CDI76115.1 - 0.033 14.2 15.2 0.041 13.9 15.2 1.1 1 0 0 1 1 1 0 Ribonucleases P/MRP protein subunit POP1 DUF913 PF06025.12 CDI76115.1 - 0.18 10.7 10.9 0.2 10.6 10.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PPL5 PF18168.1 CDI76115.1 - 0.22 10.8 10.7 0.24 10.7 10.7 1.0 1 0 0 1 1 1 0 Prim-pol family 5 DUF4569 PF15133.6 CDI76115.1 - 0.25 11.0 21.7 0.28 10.9 21.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) RR_TM4-6 PF06459.12 CDI76115.1 - 0.3 10.9 16.0 0.3 10.9 16.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 V_ATPase_I PF01496.19 CDI76115.1 - 0.35 8.7 18.6 0.37 8.7 18.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tim54 PF11711.8 CDI76115.1 - 0.44 9.3 14.0 0.48 9.1 14.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4746 PF15928.5 CDI76115.1 - 0.49 9.8 11.6 0.61 9.5 11.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DFRP_C PF16543.5 CDI76115.1 - 0.51 10.9 15.4 0.98 10.0 15.3 1.5 1 1 1 2 2 2 0 DRG Family Regulatory Proteins, Tma46 CobT PF06213.12 CDI76115.1 - 0.52 9.7 23.3 0.63 9.4 23.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Gti1_Pac2 PF09729.9 CDI76115.1 - 0.56 10.3 14.1 0.62 10.1 14.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Sec62 PF03839.16 CDI76115.1 - 0.79 9.2 14.3 0.92 9.0 14.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 KAsynt_C_assoc PF16197.5 CDI76115.1 - 0.84 10.1 6.2 1.2 9.7 6.2 1.3 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension Neur_chan_memb PF02932.16 CDI76115.1 - 0.98 9.4 17.7 1 9.3 17.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI76115.1 - 1.1 8.0 20.9 1.1 7.9 20.9 1.1 1 0 0 1 1 1 0 Presenilin TYW3 PF02676.14 CDI76115.1 - 1.1 8.5 7.3 1.4 8.3 7.3 1.1 1 0 0 1 1 1 0 Methyltransferase TYW3 CrgA PF06781.12 CDI76115.1 - 1.2 9.3 8.5 1.1 9.4 0.6 2.1 2 0 0 2 2 2 0 Cell division protein CrgA MDM31_MDM32 PF08118.11 CDI76115.1 - 1.2 7.7 12.0 1.4 7.5 12.0 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF4050 PF13259.6 CDI76115.1 - 1.2 9.4 14.6 1.4 9.2 14.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) DUF2072 PF09845.9 CDI76115.1 - 1.3 9.3 13.4 1.7 8.9 13.4 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein DDRGK PF09756.9 CDI76115.1 - 1.4 8.5 26.4 1.5 8.3 26.4 1.1 1 0 0 1 1 1 0 DDRGK domain PIP5K PF01504.18 CDI76115.1 - 1.5 8.0 13.8 1.8 7.7 13.8 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2126 PF09899.9 CDI76115.1 - 1.5 6.8 12.7 1.7 6.6 12.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CLN3 PF02487.17 CDI76115.1 - 1.6 7.7 14.7 1.9 7.5 14.7 1.1 1 0 0 1 1 1 0 CLN3 protein Stig1 PF04885.13 CDI76115.1 - 1.8 9.1 11.8 2.1 8.8 11.8 1.2 1 0 0 1 1 1 0 Stigma-specific protein, Stig1 Kei1 PF08552.11 CDI76115.1 - 1.8 8.4 10.7 2.2 8.1 10.7 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 BORG_CEP PF14957.6 CDI76115.1 - 1.9 9.7 11.2 2.2 9.5 11.2 1.2 1 0 0 1 1 1 0 Cdc42 effector Auxin_canalis PF05703.11 CDI76115.1 - 2.4 8.0 10.4 3 7.7 10.4 1.0 1 0 0 1 1 1 0 Auxin canalisation DUF3314 PF11771.8 CDI76115.1 - 2.6 8.2 9.9 2.9 8.0 9.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3314) DUF2828 PF11443.8 CDI76115.1 - 2.7 6.0 17.3 2.8 5.9 17.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Serinc PF03348.15 CDI76115.1 - 2.7 6.8 11.1 3.2 6.6 11.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) OATP PF03137.20 CDI76115.1 - 3.6 5.8 10.1 4.4 5.5 10.1 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family STAC2_u1 PF16664.5 CDI76115.1 - 4 7.9 12.1 4.8 7.6 12.1 1.3 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 SLC12 PF03522.15 CDI76115.1 - 4.6 6.1 19.6 4.7 6.1 19.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 HCO3_cotransp PF00955.21 CDI76115.1 - 5.1 5.8 9.0 6.1 5.5 9.0 1.0 1 0 0 1 1 1 0 HCO3- transporter family CCSAP PF15748.5 CDI76115.1 - 5.2 7.2 20.3 6.1 6.9 20.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated ALMT PF11744.8 CDI76115.1 - 5.7 5.6 14.1 6.4 5.5 14.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Ndc1_Nup PF09531.10 CDI76115.1 - 7.2 5.2 16.7 8.2 5.0 16.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAM60A PF15396.6 CDI76115.1 - 7.5 6.5 15.9 9.2 6.2 15.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Membralin PF09746.9 CDI76115.1 - 8 5.4 13.5 9.2 5.2 13.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein Bud13 PF09736.9 CDI76115.1 - 8.5 6.8 22.1 12 6.3 22.1 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex LAP1C PF05609.12 CDI76115.1 - 8.8 5.3 21.8 9.2 5.2 21.8 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Hid1 PF12722.7 CDI76115.1 - 9 4.3 18.3 8.9 4.3 18.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein eIF-3_zeta PF05091.12 CDI76115.1 - 9.5 5.1 25.1 12 4.7 25.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Baculo_PP31 PF05311.11 CDI76115.1 - 9.8 5.6 16.6 13 5.1 16.6 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Activator_LAG-3 PF11498.8 CDI76119.1 - 0.00018 20.6 31.8 0.00018 20.6 31.8 2.4 2 0 0 2 2 2 1 Transcriptional activator LAG-3 Presenilin PF01080.17 CDI76135.1 - 0.067 11.9 27.3 0.072 11.8 27.3 1.0 1 0 0 1 1 1 0 Presenilin PPL5 PF18168.1 CDI76135.1 - 0.23 10.7 14.9 0.32 10.2 14.9 1.3 1 0 0 1 1 1 0 Prim-pol family 5 RR_TM4-6 PF06459.12 CDI76135.1 - 0.33 10.7 22.8 0.38 10.5 22.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM217 PF15344.6 CDI76135.1 - 0.38 10.6 26.9 0.45 10.4 26.9 1.0 1 0 0 1 1 1 0 FAM217 family V_ATPase_I PF01496.19 CDI76135.1 - 0.8 7.6 22.1 0.89 7.4 22.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5427 PF10310.9 CDI76135.1 - 1.3 7.9 26.7 1.5 7.7 26.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Hid1 PF12722.7 CDI76135.1 - 1.4 6.9 22.2 1.4 6.9 22.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SLC12 PF03522.15 CDI76135.1 - 1.5 7.8 24.0 1.7 7.6 24.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4746 PF15928.5 CDI76135.1 - 1.6 8.1 17.0 2 7.7 17.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FNIP_N PF14636.6 CDI76135.1 - 2.2 9.3 24.3 2.6 9.0 24.3 1.1 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus SKA1 PF07160.12 CDI76135.1 - 3.2 7.5 26.8 3.3 7.5 26.8 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Endostatin PF06482.11 CDI76135.1 - 3.5 7.0 25.6 4.3 6.7 25.6 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin ALMT PF11744.8 CDI76135.1 - 4.7 5.9 19.0 5.2 5.8 19.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM60A PF15396.6 CDI76135.1 - 7.9 6.4 21.7 9.9 6.1 21.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A VIR_N PF15912.5 CDI76135.1 - 8.2 5.9 18.4 9.4 5.7 18.4 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Lin-8 PF03353.15 CDI76135.1 - 9 5.8 29.0 11 5.5 29.0 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SPX PF03105.19 CDI76137.1 - 0.0026 17.8 0.1 0.0026 17.7 0.1 1.1 1 0 0 1 1 1 1 SPX domain Apt1 PF10351.9 CDI76137.1 - 2 7.2 9.3 2.6 6.8 9.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MDM31_MDM32 PF08118.11 CDI76155.1 - 0.0034 16.1 1.9 0.0036 16.1 1.9 1.0 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins Spt20 PF12090.8 CDI76155.1 - 0.013 15.2 33.1 0.014 15.0 33.1 1.1 1 0 0 1 1 1 0 Spt20 family Pex14_N PF04695.13 CDI76155.1 - 0.026 15.2 13.6 0.025 15.3 13.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 CDI76155.1 - 0.029 14.4 27.0 0.03 14.3 27.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med19 PF10278.9 CDI76155.1 - 0.036 14.0 5.0 0.044 13.7 5.0 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 MMR1 PF08505.10 CDI76155.1 - 0.041 14.2 11.6 0.043 14.1 11.6 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Paf1 PF03985.13 CDI76155.1 - 0.056 12.4 14.2 0.059 12.4 14.2 1.0 1 0 0 1 1 1 0 Paf1 DDHD PF02862.17 CDI76155.1 - 0.061 13.5 8.5 0.065 13.4 8.5 1.0 1 0 0 1 1 1 0 DDHD domain EPL1 PF10513.9 CDI76155.1 - 0.064 13.6 11.8 0.065 13.6 11.8 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like Pex26 PF07163.12 CDI76155.1 - 0.069 12.4 17.0 0.084 12.2 17.0 1.1 1 0 0 1 1 1 0 Pex26 protein Coilin_N PF15862.5 CDI76155.1 - 0.075 12.8 10.6 0.083 12.7 10.6 1.2 1 0 0 1 1 1 0 Coilin N-terminus CPSF100_C PF13299.6 CDI76155.1 - 0.084 13.1 7.7 0.087 13.0 7.7 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 CDI76155.1 - 0.12 11.4 4.3 0.12 11.4 4.3 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TMEM174 PF15029.6 CDI76155.1 - 0.12 12.1 2.0 0.13 11.9 2.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 174 SpoIIP PF07454.11 CDI76155.1 - 0.13 11.7 11.9 0.15 11.5 11.9 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Androgen_recep PF02166.16 CDI76155.1 - 0.15 10.8 27.7 0.16 10.8 27.7 1.0 1 0 0 1 1 1 0 Androgen receptor Suf PF05843.14 CDI76155.1 - 0.18 11.7 13.4 0.19 11.7 13.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF719 PF05334.13 CDI76155.1 - 0.19 11.9 9.2 0.23 11.7 9.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF719) TERB2 PF15101.6 CDI76155.1 - 0.2 11.7 16.2 0.23 11.5 16.2 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 eIF-3_zeta PF05091.12 CDI76155.1 - 0.21 10.5 15.4 0.22 10.4 15.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rrn6 PF10214.9 CDI76155.1 - 0.22 10.0 16.0 0.23 9.9 16.0 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor FAM60A PF15396.6 CDI76155.1 - 0.28 11.1 5.2 0.28 11.1 5.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A RR_TM4-6 PF06459.12 CDI76155.1 - 0.31 10.8 9.9 0.32 10.8 9.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4175 PF13779.6 CDI76155.1 - 0.31 8.9 26.8 0.31 8.9 26.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) AIF_C PF14721.6 CDI76155.1 - 0.38 11.1 6.9 0.44 10.9 6.9 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term MCU PF04678.13 CDI76155.1 - 0.4 10.8 7.6 0.44 10.6 7.6 1.0 1 0 0 1 1 1 0 Mitochondrial calcium uniporter UPF0560 PF10577.9 CDI76155.1 - 0.4 9.1 17.2 0.44 9.0 17.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PAT1 PF09770.9 CDI76155.1 - 0.46 8.7 17.5 0.48 8.6 17.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 V_ATPase_I PF01496.19 CDI76155.1 - 0.48 8.3 10.7 0.5 8.2 10.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Neur_chan_memb PF02932.16 CDI76155.1 - 0.49 10.4 7.1 0.51 10.4 7.1 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI76155.1 - 0.51 9.0 13.3 0.53 9.0 13.3 1.0 1 0 0 1 1 1 0 Presenilin Band_3_cyto PF07565.13 CDI76155.1 - 0.58 9.9 8.6 0.6 9.9 8.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MecA PF05389.12 CDI76155.1 - 0.6 9.7 9.2 0.65 9.6 9.2 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF2126 PF09899.9 CDI76155.1 - 0.62 8.1 6.3 0.64 8.0 6.3 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) MMU163 PF17119.5 CDI76155.1 - 0.63 9.1 5.0 0.67 9.1 5.0 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Membralin PF09746.9 CDI76155.1 - 0.65 9.0 4.7 0.67 8.9 4.7 1.0 1 0 0 1 1 1 0 Tumour-associated protein EIIBC-GUT_N PF03612.14 CDI76155.1 - 0.69 9.6 9.2 0.73 9.5 9.2 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Peptidase_S49_N PF08496.10 CDI76155.1 - 0.75 9.8 9.8 0.84 9.7 9.8 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FAM176 PF14851.6 CDI76155.1 - 0.79 9.4 6.8 1 9.0 6.8 1.3 1 0 0 1 1 1 0 FAM176 family NARP1 PF12569.8 CDI76155.1 - 1.1 8.1 11.5 1.2 8.0 11.5 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4407 PF14362.6 CDI76155.1 - 1.2 8.4 14.4 1.2 8.4 14.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Med15 PF09606.10 CDI76155.1 - 1.4 7.5 29.5 1.5 7.4 29.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4446 PF14584.6 CDI76155.1 - 1.4 8.9 7.1 1.7 8.6 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) ALMT PF11744.8 CDI76155.1 - 1.6 7.4 6.3 1.7 7.4 6.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Tim54 PF11711.8 CDI76155.1 - 1.8 7.3 11.1 2 7.1 11.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Hid1 PF12722.7 CDI76155.1 - 1.9 6.5 10.1 1.9 6.5 10.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MAJIN PF15077.6 CDI76155.1 - 2.4 7.9 7.9 2.5 7.8 7.9 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Orf78 PF06024.12 CDI76155.1 - 2.4 8.5 6.2 2.9 8.2 6.2 1.2 1 0 0 1 1 1 0 Orf78 (ac78) PPL5 PF18168.1 CDI76155.1 - 2.8 7.2 8.1 3.3 6.9 8.1 1.1 1 0 0 1 1 1 0 Prim-pol family 5 SID-1_RNA_chan PF13965.6 CDI76155.1 - 2.8 6.2 4.2 2.6 6.3 4.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2722 PF10846.8 CDI76155.1 - 2.9 6.8 32.7 3.4 6.5 32.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CobT PF06213.12 CDI76155.1 - 3 7.1 22.1 3.5 6.9 22.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT EOS1 PF12326.8 CDI76155.1 - 3.1 7.7 6.1 3.4 7.6 6.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein ORC_WH_C PF18137.1 CDI76155.1 - 3.1 7.9 14.2 4 7.5 14.2 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal DUF2828 PF11443.8 CDI76155.1 - 3.2 5.7 10.8 3.5 5.6 10.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Plasmodium_Vir PF05795.11 CDI76155.1 - 3.4 7.0 6.4 3.3 7.0 6.4 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Gti1_Pac2 PF09729.9 CDI76155.1 - 3.4 7.7 10.2 4.1 7.5 10.2 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Ctr PF04145.15 CDI76155.1 - 3.8 8.1 7.3 4.6 7.9 7.3 1.1 1 0 0 1 1 1 0 Ctr copper transporter family FAM70 PF14967.6 CDI76155.1 - 3.9 6.9 4.7 4 6.8 4.7 1.0 1 0 0 1 1 1 0 FAM70 protein Peroxin-13_N PF04088.13 CDI76155.1 - 4.1 7.7 7.1 4.7 7.5 7.1 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Borrelia_P83 PF05262.11 CDI76155.1 - 4.6 5.6 14.9 4.9 5.5 14.9 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF1980 PF09323.10 CDI76155.1 - 4.6 7.1 8.6 5 7.0 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF4746 PF15928.5 CDI76155.1 - 4.6 6.6 9.9 5.3 6.4 9.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TFB6 PF17110.5 CDI76155.1 - 5.7 6.6 8.7 6.8 6.4 8.7 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Connexin PF00029.19 CDI76155.1 - 6 6.6 10.4 6.9 6.3 10.4 1.1 1 0 0 1 1 1 0 Connexin Serinc PF03348.15 CDI76155.1 - 6 5.7 7.4 6.2 5.6 7.4 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Zip PF02535.22 CDI76155.1 - 6.4 5.9 4.9 6.6 5.9 4.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PIP5K PF01504.18 CDI76155.1 - 6.5 5.9 10.8 7.3 5.7 10.8 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase G0-G1_switch_2 PF15103.6 CDI76155.1 - 6.8 7.2 10.5 9.2 6.8 10.5 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 Roughex PF06020.11 CDI76155.1 - 7.5 5.5 17.3 9.8 5.2 17.3 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF3464 PF11947.8 CDI76155.1 - 7.9 6.2 14.0 10 5.9 14.0 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 CLN3 PF02487.17 CDI76155.1 - 8.1 5.4 9.6 9.2 5.2 9.6 1.0 1 0 0 1 1 1 0 CLN3 protein Folliculin PF11704.8 CDI76155.1 - 9.8 6.0 11.5 12 5.7 11.5 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport PPP4R2 PF09184.11 CDI76156.1 - 6.3 6.3 39.0 1.3 8.5 21.6 2.0 2 0 0 2 2 2 0 PPP4R2 Bromodomain PF00439.25 CDI76164.1 - 6.7e-19 67.7 0.0 1e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Bromodomain Ribosomal_60s PF00428.19 CDI76164.1 - 0.87 10.2 6.8 1.6 9.4 6.8 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Acetyltransf_1 PF00583.25 CDI76167.1 - 3.1e-10 40.3 0.0 6.3e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDI76167.1 - 0.00068 19.6 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDI76167.1 - 0.001 19.4 0.0 0.0024 18.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Exonuc_VII_L PF02601.15 CDI76168.1 - 0.011 15.3 1.8 0.021 14.4 1.8 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Alpha-E PF04168.12 CDI76168.1 - 0.014 15.2 0.4 0.03 14.1 0.4 1.6 1 0 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. Flg_hook PF02120.16 CDI76168.1 - 0.047 13.6 0.5 0.4 10.6 0.1 2.7 2 1 0 2 2 2 0 Flagellar hook-length control protein FliK ATG16 PF08614.11 CDI76169.1 - 0.0014 18.9 5.8 0.0014 18.9 5.8 2.7 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) APG6_N PF17675.1 CDI76169.1 - 0.0017 18.8 7.9 0.0017 18.8 7.9 2.1 2 0 0 2 2 2 1 Apg6 coiled-coil region HAP1_N PF04849.13 CDI76169.1 - 0.019 14.2 8.2 0.033 13.4 8.2 1.4 1 0 0 1 1 1 0 HAP1 N-terminal conserved region HMMR_N PF15905.5 CDI76169.1 - 0.034 13.6 8.9 0.017 14.6 6.3 1.7 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Csm1_N PF18504.1 CDI76169.1 - 0.051 13.9 9.9 0.46 10.9 0.7 2.9 3 0 0 3 3 3 0 Csm1 N-terminal domain PAH PF02671.21 CDI76169.1 - 0.056 13.6 0.2 0.14 12.3 0.2 1.7 1 0 0 1 1 1 0 Paired amphipathic helix repeat Spc7 PF08317.11 CDI76169.1 - 0.059 12.3 8.5 0.02 13.8 5.1 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein Tropomyosin_1 PF12718.7 CDI76169.1 - 0.082 13.1 10.9 0.065 13.4 7.3 2.0 2 0 0 2 2 2 0 Tropomyosin like Phlebovirus_NSM PF07246.11 CDI76169.1 - 0.097 12.0 3.7 0.15 11.4 3.7 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M GIT_CC PF16559.5 CDI76169.1 - 0.23 11.4 10.1 1.8 8.5 3.6 2.6 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Jnk-SapK_ap_N PF09744.9 CDI76169.1 - 0.26 11.5 14.7 0.21 11.8 9.1 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 HAUS-augmin3 PF14932.6 CDI76169.1 - 0.3 10.6 12.8 0.14 11.7 8.1 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 CtIP_N PF10482.9 CDI76169.1 - 0.4 10.7 9.3 0.23 11.5 5.3 2.2 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain ADIP PF11559.8 CDI76169.1 - 0.7 10.0 15.9 0.26 11.3 11.3 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF16 PF01519.16 CDI76169.1 - 1 9.9 9.5 0.88 10.1 6.8 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 TMF_DNA_bd PF12329.8 CDI76169.1 - 1.1 9.4 15.3 3.3 7.8 9.2 2.8 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding UPF0242 PF06785.11 CDI76169.1 - 1.4 9.0 10.5 0.63 10.1 6.6 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Phage_GP20 PF06810.11 CDI76169.1 - 1.6 8.5 10.1 0.69 9.7 5.0 2.4 2 1 0 2 2 2 0 Phage minor structural protein GP20 DUF4094 PF13334.6 CDI76169.1 - 3.1 8.3 6.8 1.7 9.1 0.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) FAM76 PF16046.5 CDI76169.1 - 4.6 6.5 10.1 2.2 7.6 6.9 1.8 2 0 0 2 2 2 0 FAM76 protein bZIP_1 PF00170.21 CDI76169.1 - 5.2 7.2 11.4 5.8 7.1 4.8 3.2 2 1 0 3 3 3 0 bZIP transcription factor MMR_HSR1 PF01926.23 CDI76170.1 - 9.7e-17 61.1 0.1 6e-15 55.3 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDI76170.1 - 5.4e-06 26.0 0.0 2.3e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDI76170.1 - 5.6e-06 26.4 0.0 0.0078 16.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CDI76170.1 - 1.2 9.2 4.9 0.35 10.9 0.2 2.5 3 1 1 4 4 4 0 Dynamin family zf-CDGSH PF09360.10 CDI76171.1 - 1e-08 35.2 0.3 3.1e-08 33.7 0.3 1.8 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type UPF0147 PF03685.13 CDI76171.1 - 0.2 11.7 0.0 1.5 9.0 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0147) BT1 PF03092.16 CDI76174.1 - 1.5e-34 119.1 7.1 1.7e-18 66.2 0.6 2.3 2 0 0 2 2 2 2 BT1 family Mt_ATP-synt_B PF05405.14 CDI76174.1 - 0.013 15.1 1.8 0.032 13.8 1.8 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF5418 PF17439.2 CDI76174.1 - 0.046 13.8 1.6 0.093 12.8 1.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5418) DUF2273 PF10031.9 CDI76174.1 - 0.22 11.5 1.5 0.9 9.6 0.3 2.5 1 1 1 2 2 2 0 Small integral membrane protein (DUF2273) STT3 PF02516.14 CDI76175.1 - 1.5e-53 182.4 36.9 2.6e-53 181.7 37.0 1.4 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit Foie-gras_1 PF11817.8 CDI76176.1 - 7.3e-07 29.0 0.1 7.3e-07 29.0 0.1 1.8 2 0 0 2 2 2 1 Foie gras liver health family 1 WD40 PF00400.32 CDI76177.1 - 0.016 16.1 5.8 2.1 9.4 0.2 5.2 5 0 0 5 5 5 0 WD domain, G-beta repeat FUSC_2 PF13515.6 CDI76179.1 - 7.1e-13 48.8 9.2 7.1e-13 48.8 9.2 3.3 3 0 0 3 3 3 1 Fusaric acid resistance protein-like TetR_C_16 PF17920.1 CDI76179.1 - 0.47 10.7 6.1 1.3 9.2 0.0 4.0 4 0 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain MMtag PF10159.9 CDI76180.1 - 5.5e-18 65.0 3.3 5.5e-18 65.0 3.3 3.9 4 1 0 4 4 4 1 Multiple myeloma tumor-associated Kinase-like PF14531.6 CDI76180.1 - 0.14 11.5 1.6 0.2 11.0 1.6 1.2 1 0 0 1 1 1 0 Kinase-like E1-E2_ATPase PF00122.20 CDI76183.1 - 1.2e-34 119.4 0.0 1.2e-34 119.4 0.0 3.1 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CDI76183.1 - 3e-29 102.0 0.1 3e-29 102.0 0.1 4.1 5 0 0 5 5 5 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CDI76183.1 - 7e-17 62.4 0.3 3.7e-10 40.5 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDI76183.1 - 1.2e-14 54.2 0.1 2.6e-14 53.0 0.1 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CDI76183.1 - 2.2e-08 33.7 0.0 6.8e-08 32.1 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CDI76183.1 - 0.00028 20.7 0.5 0.0017 18.2 0.4 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase YABBY PF04690.13 CDI76183.1 - 0.025 15.1 0.0 0.055 14.0 0.0 1.5 1 0 0 1 1 1 0 YABBY protein PAP_central PF04928.17 CDI76183.1 - 0.081 11.9 0.2 0.21 10.6 0.2 1.6 1 0 0 1 1 1 0 Poly(A) polymerase central domain AMP-binding PF00501.28 CDI76184.1 - 1.2e-81 274.5 0.0 7.4e-81 271.9 0.0 1.9 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDI76184.1 - 4.2e-18 66.1 1.8 9e-18 65.0 1.8 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 CDI76184.1 - 1.1e-16 60.5 1.4 2.7e-16 59.2 1.4 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus UPF0139 PF03669.13 CDI76190.1 - 0.42 10.5 0.1 0.42 10.5 0.1 2.5 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0139) Spt20 PF12090.8 CDI76191.1 - 0.0066 16.1 33.0 0.0066 16.1 33.0 8.1 5 3 0 5 5 5 1 Spt20 family SpoIIP PF07454.11 CDI76191.1 - 0.0095 15.4 6.5 0.0095 15.4 6.5 6.5 3 1 2 5 5 5 2 Stage II sporulation protein P (SpoIIP) Cpn60_TCP1 PF00118.24 CDI76192.1 - 1.3e-103 347.2 10.8 1.2e-61 208.8 2.4 2.0 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family LUC7 PF03194.15 CDI76193.1 - 3.4e-47 161.2 1.7 4e-47 161.0 1.7 1.0 1 0 0 1 1 1 1 LUC7 N_terminus HSCB_C PF07743.13 CDI76193.1 - 0.0096 16.4 6.1 0.014 15.8 1.7 2.3 1 1 1 2 2 2 1 HSCB C-terminal oligomerisation domain Occludin_ELL PF07303.13 CDI76193.1 - 0.02 15.6 3.4 0.046 14.5 3.5 1.6 1 1 1 2 2 2 0 Occludin homology domain SKA1 PF07160.12 CDI76193.1 - 0.021 14.7 1.7 0.03 14.2 1.7 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 FCD PF07729.12 CDI76193.1 - 0.028 14.9 2.7 0.058 13.8 1.0 2.1 1 1 1 2 2 2 0 FCD domain FlgN PF05130.12 CDI76193.1 - 0.053 14.0 4.3 1.4 9.4 0.2 2.2 1 1 1 2 2 2 0 FlgN protein HlyD_2 PF12700.7 CDI76193.1 - 0.075 11.8 2.5 0.094 11.4 2.5 1.1 1 0 0 1 1 1 0 HlyD family secretion protein DUF2357 PF09823.9 CDI76193.1 - 0.089 12.0 1.9 0.14 11.4 1.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2357) Exonuc_VII_L PF02601.15 CDI76193.1 - 0.099 12.2 2.8 0.12 11.9 2.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ran-binding PF05508.11 CDI76193.1 - 0.1 11.6 1.0 0.15 11.0 1.0 1.2 1 0 0 1 1 1 0 RanGTP-binding protein DUF1690 PF07956.11 CDI76193.1 - 0.11 12.9 7.3 0.57 10.6 7.4 1.8 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) NPV_P10 PF05531.12 CDI76193.1 - 0.14 12.6 5.2 4.6 7.8 0.1 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DASH_Dad4 PF08650.10 CDI76193.1 - 0.19 11.7 0.1 0.19 11.7 0.1 2.6 2 1 0 2 2 2 0 DASH complex subunit Dad4 IML1 PF12257.8 CDI76193.1 - 0.21 10.7 0.6 0.76 8.8 0.3 1.8 1 1 1 2 2 2 0 Vacuolar membrane-associated protein Iml1 ABC_tran_CTD PF16326.5 CDI76193.1 - 0.21 11.9 6.4 0.21 11.8 4.2 2.0 1 1 0 2 2 2 0 ABC transporter C-terminal domain DUF1090 PF06476.12 CDI76193.1 - 0.25 11.5 5.2 0.42 10.8 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) ADIP PF11559.8 CDI76193.1 - 0.37 10.9 8.4 0.74 9.9 4.4 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding GIT_CC PF16559.5 CDI76193.1 - 0.46 10.4 3.4 0.82 9.6 0.0 2.6 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4404 PF14357.6 CDI76193.1 - 0.79 10.4 4.2 3.5 8.3 4.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) V_ATPase_I PF01496.19 CDI76193.1 - 0.8 7.6 2.4 0.97 7.3 2.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SlyX PF04102.12 CDI76193.1 - 1.1 9.9 6.5 36 5.1 0.1 2.7 2 1 0 2 2 2 0 SlyX Rho_Binding PF08912.11 CDI76193.1 - 1.8 9.4 7.3 19 6.2 0.1 2.4 2 0 0 2 2 2 0 Rho Binding bZIP_2 PF07716.15 CDI76193.1 - 2.5 8.2 13.1 12 6.0 0.1 3.3 3 0 0 3 3 3 0 Basic region leucine zipper YabA PF06156.13 CDI76193.1 - 6.1 7.5 6.6 19 6.0 5.8 1.9 1 1 1 2 2 2 0 Initiation control protein YabA DnaJ-X PF14308.6 CDI76194.1 - 1.6e-18 67.0 14.5 2.9e-15 56.3 0.1 3.2 2 1 1 3 3 3 2 X-domain of DnaJ-containing ATG_C PF09333.11 CDI76194.1 - 5.2e-06 26.7 0.4 2.1e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain SR-25 PF10500.9 CDI76194.1 - 0.00099 18.8 15.1 0.00099 18.8 15.1 3.1 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein Med15 PF09606.10 CDI76194.1 - 0.0017 17.2 29.8 0.013 14.3 10.7 2.2 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal Pex14_N PF04695.13 CDI76194.1 - 0.02 15.5 33.4 1.7 9.3 6.8 3.4 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region N-SET PF11764.8 CDI76194.1 - 0.035 14.2 1.9 0.035 14.2 1.9 3.8 3 1 0 3 3 2 0 COMPASS (Complex proteins associated with Set1p) component N DUF2722 PF10846.8 CDI76194.1 - 0.4 9.6 39.4 0.71 8.8 11.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) EBP50_C PF09007.11 CDI76194.1 - 0.83 10.7 26.3 1.4 9.9 2.7 3.3 3 0 0 3 3 3 0 EBP50, C-terminal Porph_ging PF09697.10 CDI76194.1 - 1.2 9.8 9.3 2.1 9.0 1.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) EPL1 PF10513.9 CDI76194.1 - 2.8 8.3 23.7 1.6 9.1 6.6 3.0 3 0 0 3 3 3 0 Enhancer of polycomb-like PepSY_TM PF03929.16 CDI76194.1 - 4.2 6.9 15.8 7.4 6.1 0.0 3.1 3 0 0 3 3 3 0 PepSY-associated TM region Dsh_C PF12316.8 CDI76194.1 - 4.7 7.6 28.9 0.78 10.1 4.2 3.0 3 0 0 3 3 3 0 Segment polarity protein dishevelled (Dsh) C terminal TERB2 PF15101.6 CDI76194.1 - 5.6 7.0 34.0 8.2 6.4 12.0 3.1 3 0 0 3 3 3 0 Telomere-associated protein TERB2 RLL PF10036.9 CDI76194.1 - 6.7 6.5 18.3 1.9 8.2 3.7 2.4 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein CPSF100_C PF13299.6 CDI76194.1 - 7.3 6.7 19.3 28 4.8 1.8 3.1 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal FAM176 PF14851.6 CDI76194.1 - 7.3 6.2 15.0 21 4.8 0.5 3.1 3 0 0 3 3 3 0 FAM176 family A_amylase_inhib PF01356.19 CDI76207.1 - 0.0014 18.6 0.2 0.003 17.5 0.2 1.5 1 0 0 1 1 1 1 Alpha amylase inhibitor Apc15p PF05841.11 CDI76207.1 - 0.0099 16.7 2.6 0.0099 16.7 2.6 4.5 2 2 2 4 4 4 1 Apc15p protein RIFIN PF02009.16 CDI76207.1 - 0.74 9.7 19.8 1.2 8.9 19.8 1.3 1 0 0 1 1 1 0 Rifin Peptidase_S49_N PF08496.10 CDI76207.1 - 4.5 7.3 22.8 11 6.0 22.8 1.8 1 0 0 1 1 1 0 Peptidase family S49 N-terminal GAGA_bind PF06217.12 CDI76207.1 - 9.6 6.4 24.8 15 5.7 24.8 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Rib_5-P_isom_A PF06026.14 CDI76211.1 - 4.6e-45 153.3 0.0 3.1e-24 85.5 0.0 2.1 2 0 0 2 2 2 2 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DDHD PF02862.17 CDI76214.1 - 7.6e-05 23.0 2.0 8.3e-05 22.8 2.0 1.3 1 0 0 1 1 1 1 DDHD domain Hamartin PF04388.12 CDI76214.1 - 0.0035 16.1 6.8 0.0044 15.8 6.8 1.1 1 0 0 1 1 1 1 Hamartin protein Ndc1_Nup PF09531.10 CDI76214.1 - 0.0036 16.1 3.4 0.0034 16.2 3.4 1.2 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Pkinase_fungal PF17667.1 CDI76214.1 - 0.0037 16.1 1.2 0.0048 15.7 1.2 1.1 1 0 0 1 1 1 1 Fungal protein kinase Zip PF02535.22 CDI76214.1 - 0.011 15.0 1.4 0.015 14.6 1.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter TFIIA PF03153.13 CDI76214.1 - 0.016 15.2 35.6 0.016 15.2 35.6 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SpoIIP PF07454.11 CDI76214.1 - 0.047 13.2 13.0 0.064 12.7 13.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF5427 PF10310.9 CDI76214.1 - 0.056 12.4 16.4 0.11 11.4 16.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5427) NARP1 PF12569.8 CDI76214.1 - 0.065 12.1 15.6 0.091 11.7 15.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Otopetrin PF03189.13 CDI76214.1 - 0.089 11.6 1.8 0.1 11.4 1.8 1.1 1 0 0 1 1 1 0 Otopetrin CDC45 PF02724.14 CDI76214.1 - 0.1 10.9 13.5 0.13 10.5 13.5 1.1 1 0 0 1 1 1 0 CDC45-like protein PAT1 PF09770.9 CDI76214.1 - 0.15 10.3 25.3 0.21 9.8 25.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BORG_CEP PF14957.6 CDI76214.1 - 0.18 13.0 19.3 0.34 12.1 19.3 1.3 1 0 0 1 1 1 0 Cdc42 effector VIR_N PF15912.5 CDI76214.1 - 0.24 11.0 10.0 0.36 10.4 10.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Lin-8 PF03353.15 CDI76214.1 - 0.27 10.8 18.6 0.37 10.3 18.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PPL5 PF18168.1 CDI76214.1 - 0.33 10.2 9.8 0.49 9.6 9.8 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF2632 PF10943.8 CDI76214.1 - 0.34 10.4 0.6 0.48 10.0 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2632) DUF913 PF06025.12 CDI76214.1 - 0.43 9.5 10.8 0.72 8.8 10.8 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 CDI76214.1 - 0.62 10.0 13.5 0.91 9.5 13.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Peptidase_S64 PF08192.11 CDI76214.1 - 0.77 8.2 13.9 1 7.8 13.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 Exonuc_VII_L PF02601.15 CDI76214.1 - 1 8.9 15.8 1.7 8.1 15.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Presenilin PF01080.17 CDI76214.1 - 1.1 7.9 23.9 1.7 7.4 23.9 1.1 1 0 0 1 1 1 0 Presenilin UPF0560 PF10577.9 CDI76214.1 - 1.4 7.4 22.8 2.1 6.8 22.8 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Peptidase_U57 PF05582.12 CDI76214.1 - 1.4 8.1 8.2 2 7.6 8.2 1.3 1 0 0 1 1 1 0 YabG peptidase U57 Endonuc_Holl PF10107.9 CDI76214.1 - 1.4 8.7 10.0 2.3 8.1 10.0 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase GREB1 PF15782.5 CDI76214.1 - 1.7 5.7 17.0 2.2 5.3 17.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PTPRCAP PF15713.5 CDI76214.1 - 1.9 8.8 19.9 4.2 7.6 19.9 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Ureide_permease PF07168.11 CDI76214.1 - 2 7.0 5.1 3.4 6.3 5.1 1.3 1 0 0 1 1 1 0 Ureide permease SLC12 PF03522.15 CDI76214.1 - 2.1 7.3 17.8 2.9 6.8 17.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Velvet PF11754.8 CDI76214.1 - 4.5 7.2 17.7 7.3 6.4 17.7 1.3 1 0 0 1 1 1 0 Velvet factor PA26 PF04636.13 CDI76214.1 - 5 5.9 13.1 6.9 5.5 13.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Pal1 PF08316.11 CDI76214.1 - 5.4 7.8 8.3 13 6.6 8.3 1.6 1 0 0 1 1 1 0 Pal1 cell morphology protein Neur_chan_memb PF02932.16 CDI76214.1 - 5.8 6.9 14.9 10 6.1 14.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Dicty_REP PF05086.12 CDI76214.1 - 6.5 4.6 10.3 8.1 4.3 10.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein MCM_bind PF09739.9 CDI76214.1 - 7.2 4.9 17.6 10 4.4 17.6 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor RR_TM4-6 PF06459.12 CDI76214.1 - 7.4 6.3 22.4 11 5.7 22.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MMR1 PF08505.10 CDI76214.1 - 9.8 6.4 22.6 15 5.8 22.6 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein 60KD_IMP PF02096.20 CDI76216.1 - 0.00079 19.4 7.9 0.00085 19.3 7.9 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein MAT1 PF06391.13 CDI76216.1 - 0.043 13.6 20.8 0.047 13.5 20.8 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 SpoIIP PF07454.11 CDI76216.1 - 0.21 11.0 14.7 0.25 10.8 14.7 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PIP5K PF01504.18 CDI76216.1 - 0.22 10.7 12.0 0.25 10.6 12.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Lin-8 PF03353.15 CDI76216.1 - 0.37 10.3 19.5 0.39 10.2 19.5 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Band_3_cyto PF07565.13 CDI76216.1 - 0.67 9.7 12.0 0.71 9.6 12.0 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MMR1 PF08505.10 CDI76216.1 - 0.77 10.0 15.7 0.81 9.9 15.7 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein FRQ PF09421.10 CDI76216.1 - 0.84 7.6 11.3 0.96 7.4 11.3 1.2 1 0 0 1 1 1 0 Frequency clock protein V_ATPase_I PF01496.19 CDI76216.1 - 0.86 7.4 13.5 0.81 7.5 13.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TERB2 PF15101.6 CDI76216.1 - 1 9.4 19.1 1.2 9.2 19.1 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF913 PF06025.12 CDI76216.1 - 1.1 8.2 11.0 1.4 7.8 11.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 CDI76216.1 - 1.2 9.0 8.7 1.3 8.9 8.7 1.3 1 0 0 1 1 1 0 Protein Family FAM60A PAT1 PF09770.9 CDI76216.1 - 1.3 7.2 28.8 1.3 7.2 28.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S64 PF08192.11 CDI76216.1 - 1.4 7.4 11.4 1.2 7.5 11.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 Tim54 PF11711.8 CDI76216.1 - 1.4 7.7 10.8 1.4 7.6 10.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SLC12 PF03522.15 CDI76216.1 - 1.5 7.8 14.5 1.5 7.8 14.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Maf1 PF09174.10 CDI76216.1 - 1.6 8.8 14.0 2.1 8.5 14.0 1.1 1 0 0 1 1 1 0 Maf1 regulator PIG-S PF10510.9 CDI76216.1 - 1.7 7.4 16.5 2 7.1 16.5 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Hid1 PF12722.7 CDI76216.1 - 2 6.4 12.3 1.8 6.6 12.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1387 PF07139.11 CDI76216.1 - 2.4 7.8 16.3 2.7 7.7 16.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF572 PF04502.13 CDI76216.1 - 2.4 7.7 14.4 2.7 7.5 14.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Draxin PF15550.6 CDI76216.1 - 2.5 7.9 10.0 2.8 7.8 10.0 1.2 1 0 0 1 1 1 0 Draxin Sec62 PF03839.16 CDI76216.1 - 2.9 7.4 11.4 3.2 7.2 11.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Miga PF10265.9 CDI76216.1 - 2.9 6.8 13.2 3 6.7 13.2 1.1 1 0 0 1 1 1 0 Mitoguardin DUF4746 PF15928.5 CDI76216.1 - 3 7.2 8.3 3.1 7.2 8.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) HD-ZIP_N PF04618.12 CDI76216.1 - 3.2 8.3 6.3 4.7 7.8 6.3 1.3 1 0 0 1 1 1 0 HD-ZIP protein N terminus RHSP PF07999.11 CDI76216.1 - 3.3 6.4 6.2 3.7 6.3 6.2 1.1 1 0 0 1 1 1 0 Retrotransposon hot spot protein Connexin PF00029.19 CDI76216.1 - 3.5 7.3 15.8 4.5 7.0 15.8 1.1 1 0 0 1 1 1 0 Connexin DUF4638 PF15472.6 CDI76216.1 - 3.7 7.2 12.7 3.8 7.2 12.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) RLL PF10036.9 CDI76216.1 - 3.8 7.3 23.4 5.7 6.7 23.4 1.3 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein MDM10 PF12519.8 CDI76216.1 - 4.8 5.9 12.2 4.8 5.9 12.2 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Neur_chan_memb PF02932.16 CDI76216.1 - 7 6.6 12.1 7.7 6.5 12.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CSG2 PF16965.5 CDI76216.1 - 7.6 5.4 11.1 8.8 5.2 11.1 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Afi1 PF07792.12 CDI76216.1 - 7.7 7.0 17.0 9.7 6.7 17.0 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking SRP-alpha_N PF04086.13 CDI76216.1 - 8.3 6.2 18.4 9.4 6.1 18.4 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Stevor PF17410.2 CDI76216.1 - 9.1 5.7 11.6 11 5.5 11.6 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Membralin PF09746.9 CDI76216.1 - 9.8 5.1 11.3 11 4.9 11.3 1.2 1 0 0 1 1 1 0 Tumour-associated protein SseC PF04888.12 CDI76222.1 - 0.004 16.8 15.2 0.004 16.8 15.2 5.9 5 1 1 6 6 6 2 Secretion system effector C (SseC) like family Caldesmon PF02029.15 CDI76222.1 - 1.4 7.6 103.5 1.9 7.1 68.4 2.4 2 0 0 2 2 2 0 Caldesmon RskA PF10099.9 CDI76232.1 - 7.3e-06 26.4 7.9 7.3e-06 26.4 7.9 2.2 1 1 1 2 2 2 1 Anti-sigma-K factor rskA PCO_ADO PF07847.12 CDI76232.1 - 0.00041 19.9 1.4 0.00078 19.0 1.4 1.4 1 0 0 1 1 1 1 PCO_ADO CsiV PF10972.8 CDI76232.1 - 0.0021 17.8 2.6 0.0021 17.8 2.6 1.9 1 1 1 2 2 2 1 Peptidoglycan-binding protein, CsiV RAB3GAP2_N PF14655.6 CDI76232.1 - 0.0031 16.8 6.4 0.0088 15.3 1.8 2.1 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus TMEM247 PF15444.6 CDI76232.1 - 0.031 14.3 0.3 0.031 14.3 0.3 1.6 2 0 0 2 2 2 0 Transmembrane protein 247 DUF4834 PF16118.5 CDI76232.1 - 0.21 12.6 4.5 2.4 9.1 2.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) ANAPC_CDC26 PF10471.9 CDI76232.1 - 2.2 9.2 23.3 6.1 7.8 12.6 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 V_ATPase_I PF01496.19 CDI76233.1 - 0.00038 18.5 16.7 0.00038 18.5 16.7 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family PIP5K PF01504.18 CDI76233.1 - 0.00097 18.4 14.1 0.0011 18.2 14.1 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase CobT PF06213.12 CDI76233.1 - 0.0014 18.1 22.4 0.0015 18.0 22.4 1.2 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT DUF4366 PF14283.6 CDI76233.1 - 0.0028 17.7 5.9 0.0036 17.4 5.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) SpoIIP PF07454.11 CDI76233.1 - 0.0037 16.8 17.9 0.0043 16.6 17.9 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) DUF913 PF06025.12 CDI76233.1 - 0.0057 15.7 8.3 0.0068 15.4 8.3 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) AIF_C PF14721.6 CDI76233.1 - 0.0069 16.7 12.4 0.0091 16.4 12.4 1.2 1 0 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term Scs3p PF10261.9 CDI76233.1 - 0.007 15.9 4.4 0.0082 15.7 4.4 1.2 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM PepSY_TM PF03929.16 CDI76233.1 - 0.0076 16.0 4.6 0.0083 15.8 4.6 1.1 1 0 0 1 1 1 1 PepSY-associated TM region RIC3 PF15361.6 CDI76233.1 - 0.012 16.0 9.5 0.016 15.6 9.5 1.3 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 TRAP_alpha PF03896.16 CDI76233.1 - 0.013 14.7 9.9 0.014 14.6 9.6 1.2 1 1 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CLN3 PF02487.17 CDI76233.1 - 0.013 14.6 12.7 0.013 14.6 12.7 1.1 1 0 0 1 1 1 0 CLN3 protein SID-1_RNA_chan PF13965.6 CDI76233.1 - 0.031 12.7 11.3 0.033 12.6 11.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TFIIA PF03153.13 CDI76233.1 - 0.032 14.2 43.7 0.037 14.0 43.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF5308 PF17233.2 CDI76233.1 - 0.051 13.8 11.8 0.062 13.5 11.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5308) CSG2 PF16965.5 CDI76233.1 - 0.053 12.5 9.1 0.057 12.4 9.1 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Serinc PF03348.15 CDI76233.1 - 0.059 12.3 8.6 0.063 12.2 8.6 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) SLC12 PF03522.15 CDI76233.1 - 0.06 12.4 20.4 0.066 12.2 20.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 CDI76233.1 - 0.077 11.8 23.4 0.096 11.4 23.4 1.2 1 0 0 1 1 1 0 Presenilin DDHD PF02862.17 CDI76233.1 - 0.086 13.0 16.3 0.11 12.7 16.3 1.2 1 0 0 1 1 1 0 DDHD domain CBP_BcsG PF11658.8 CDI76233.1 - 0.091 11.2 11.2 0.099 11.0 11.2 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG AAR2 PF05282.11 CDI76233.1 - 0.11 11.9 12.6 0.12 11.7 12.6 1.0 1 0 0 1 1 1 0 AAR2 protein Pex14_N PF04695.13 CDI76233.1 - 0.15 12.7 27.9 0.21 12.3 27.9 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HemX PF04375.14 CDI76233.1 - 0.18 11.1 38.2 0.19 11.0 38.2 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase TERB2 PF15101.6 CDI76233.1 - 0.19 11.8 24.8 0.24 11.4 24.8 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF2370 PF10176.9 CDI76233.1 - 0.19 11.4 8.5 0.22 11.2 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Folate_carrier PF01770.18 CDI76233.1 - 0.19 10.4 8.6 0.2 10.4 8.6 1.2 1 0 0 1 1 1 0 Reduced folate carrier Band_3_cyto PF07565.13 CDI76233.1 - 0.2 11.4 17.1 0.23 11.2 17.1 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2572 PF10833.8 CDI76233.1 - 0.22 11.3 17.6 0.29 10.9 17.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) DUF2126 PF09899.9 CDI76233.1 - 0.24 9.4 12.6 0.27 9.2 12.6 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) G6B PF15096.6 CDI76233.1 - 0.27 11.0 2.9 0.28 10.9 2.9 1.2 1 0 0 1 1 1 0 G6B family DUF4746 PF15928.5 CDI76233.1 - 0.28 10.6 15.0 0.35 10.3 15.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Velvet PF11754.8 CDI76233.1 - 0.28 11.1 16.8 0.33 10.8 16.8 1.1 1 0 0 1 1 1 0 Velvet factor DUF2052 PF09747.9 CDI76233.1 - 0.31 11.1 24.8 0.41 10.7 24.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) ABC2_membrane_2 PF12679.7 CDI76233.1 - 0.35 10.1 5.6 0.46 9.7 5.6 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein FAM91_C PF14648.6 CDI76233.1 - 0.37 9.6 9.3 0.42 9.4 9.3 1.2 1 0 0 1 1 1 0 FAM91 C-terminus RP-C_C PF11800.8 CDI76233.1 - 0.37 10.8 15.9 0.42 10.7 15.9 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region eIF-3_zeta PF05091.12 CDI76233.1 - 0.42 9.5 26.6 0.46 9.4 26.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Endostatin PF06482.11 CDI76233.1 - 0.42 10.0 17.3 0.46 9.9 17.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SRP-alpha_N PF04086.13 CDI76233.1 - 0.46 10.3 24.2 0.56 10.1 24.2 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal UPF0565 PF10561.9 CDI76233.1 - 0.48 9.6 10.4 0.5 9.5 10.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 ALMT PF11744.8 CDI76233.1 - 0.52 9.1 17.1 0.58 8.9 17.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter EBP50_C PF09007.11 CDI76233.1 - 0.58 11.2 20.8 0.76 10.8 20.8 1.2 1 0 0 1 1 1 0 EBP50, C-terminal Kei1 PF08552.11 CDI76233.1 - 0.58 10.0 13.0 0.75 9.6 13.0 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Tmp39 PF10271.9 CDI76233.1 - 0.6 9.1 6.0 0.62 9.0 6.0 1.1 1 0 0 1 1 1 0 Putative transmembrane protein Zip PF02535.22 CDI76233.1 - 0.6 9.3 8.5 0.65 9.1 8.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter MMU163 PF17119.5 CDI76233.1 - 0.63 9.1 8.4 0.77 8.9 8.4 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Otopetrin PF03189.13 CDI76233.1 - 0.75 8.5 10.5 0.85 8.4 10.5 1.2 1 0 0 1 1 1 0 Otopetrin Peptidase_S64 PF08192.11 CDI76233.1 - 0.8 8.1 19.6 0.89 8.0 19.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 Sin_N PF04801.13 CDI76233.1 - 0.87 8.7 32.6 0.99 8.5 32.6 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region Neur_chan_memb PF02932.16 CDI76233.1 - 1 9.4 17.0 1.3 9.1 17.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Mem_trans PF03547.18 CDI76233.1 - 1.4 7.2 5.7 1.4 7.3 5.7 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF4175 PF13779.6 CDI76233.1 - 1.4 6.7 44.3 1.4 6.7 44.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Nucleoside_tran PF01733.18 CDI76233.1 - 1.7 8.0 7.2 1.8 7.9 7.2 1.2 1 0 0 1 1 1 0 Nucleoside transporter LTV PF04180.14 CDI76233.1 - 1.7 8.3 22.5 2.2 7.9 22.5 1.1 1 0 0 1 1 1 0 Low temperature viability protein DUF2464 PF10240.9 CDI76233.1 - 1.8 8.1 13.2 2 7.9 13.2 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 HCO3_cotransp PF00955.21 CDI76233.1 - 1.9 7.3 8.3 2 7.1 8.3 1.0 1 0 0 1 1 1 0 HCO3- transporter family TAF4 PF05236.14 CDI76233.1 - 2 8.1 25.4 2.5 7.8 25.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family CDC45 PF02724.14 CDI76233.1 - 2 6.6 23.9 2.5 6.3 23.9 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4228 PF14009.6 CDI76233.1 - 2.2 8.7 13.2 2.7 8.4 13.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Acatn PF13000.7 CDI76233.1 - 2.3 6.6 4.6 2.7 6.4 4.6 1.1 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 CCSAP PF15748.5 CDI76233.1 - 2.4 8.2 30.1 3.2 7.8 30.1 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated FAM176 PF14851.6 CDI76233.1 - 2.5 7.8 19.9 5.7 6.6 19.9 1.6 1 1 0 1 1 1 0 FAM176 family MDM31_MDM32 PF08118.11 CDI76233.1 - 2.9 6.5 12.8 3.3 6.3 12.8 1.3 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Hid1 PF12722.7 CDI76233.1 - 3.2 5.8 20.4 3.5 5.6 20.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF966 PF06136.13 CDI76233.1 - 3.3 7.3 19.2 3.9 7.1 19.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Membralin PF09746.9 CDI76233.1 - 3.3 6.6 17.4 3.9 6.4 17.4 1.0 1 0 0 1 1 1 0 Tumour-associated protein PAT1 PF09770.9 CDI76233.1 - 3.4 5.8 36.7 3.9 5.6 36.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ndc1_Nup PF09531.10 CDI76233.1 - 3.8 6.1 18.3 4 6.0 18.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup O-antigen_lig PF13425.6 CDI76233.1 - 4.4 6.0 11.6 4.6 5.9 11.6 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Pannexin_like PF12534.8 CDI76233.1 - 4.8 6.2 17.0 5.4 6.0 17.0 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Dynamin_N PF00350.23 CDI76233.1 - 5 7.2 11.8 6.3 6.8 11.8 1.3 1 0 0 1 1 1 0 Dynamin family K_trans PF02705.16 CDI76233.1 - 6.4 5.2 6.2 7.8 4.9 6.2 1.1 1 0 0 1 1 1 0 K+ potassium transporter GREB1 PF15782.5 CDI76233.1 - 6.5 3.7 19.6 6.8 3.7 19.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FliP PF00813.20 CDI76233.1 - 7 6.5 9.4 8 6.3 9.4 1.2 1 0 0 1 1 1 0 FliP family Vfa1 PF08432.10 CDI76233.1 - 7.7 6.8 33.0 9.9 6.4 33.0 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Het-C PF07217.11 CDI76233.1 - 8.3 4.8 12.4 9.4 4.6 12.4 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C PDEase_I PF00233.19 CDI76236.1 - 3.9e-27 95.5 0.9 3.9e-27 95.5 0.9 1.7 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 CDI76236.1 - 0.011 16.0 0.5 0.045 14.0 0.0 2.1 2 0 0 2 2 2 0 HD domain Trypan_PARP PF05887.11 CDI76236.1 - 0.51 10.3 6.6 0.73 9.8 6.6 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) AIM3 PF17096.5 CDI76236.1 - 8.7 7.4 8.8 14 6.7 8.8 1.2 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 RskA PF10099.9 CDI76242.1 - 0.00029 21.2 11.3 0.00029 21.2 11.3 3.6 1 1 1 2 2 2 1 Anti-sigma-K factor rskA SLC12 PF03522.15 CDI76242.1 - 0.2 10.7 24.6 0.29 10.1 24.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Serinc PF03348.15 CDI76242.1 - 0.5 9.2 16.4 0.79 8.6 0.2 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) AAA_lid_9 PF17871.1 CDI76242.1 - 4.5 7.3 26.9 0.042 13.8 8.6 3.2 3 0 0 3 3 3 0 AAA lid domain DUF4834 PF16118.5 CDI76254.1 - 0.0033 18.3 1.6 0.0033 18.3 1.6 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) Nse4_C PF08743.10 CDI76254.1 - 0.0099 16.1 1.9 0.0099 16.1 1.9 2.0 2 0 0 2 2 2 1 Nse4 C-terminal Presenilin PF01080.17 CDI76254.1 - 0.034 12.9 3.0 0.041 12.7 3.0 1.1 1 0 0 1 1 1 0 Presenilin FHIPEP PF00771.20 CDI76254.1 - 0.12 10.8 4.0 0.14 10.6 4.0 1.1 1 0 0 1 1 1 0 FHIPEP family CNDH2_N PF06278.11 CDI76254.1 - 0.2 11.9 10.7 0.6 10.4 6.7 2.0 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal COPI_assoc PF08507.10 CDI76254.1 - 0.35 10.9 1.6 3.5 7.7 0.1 2.0 2 0 0 2 2 2 0 COPI associated protein TMEM208_SND2 PF05620.11 CDI76254.1 - 0.47 10.2 8.5 0.06 13.1 2.4 2.0 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Conotoxin PF02950.17 CDI76254.1 - 0.8 10.8 7.6 3 8.9 1.4 2.2 2 0 0 2 2 2 0 Conotoxin Spt20 PF12090.8 CDI76254.1 - 0.86 9.2 39.7 0.18 11.4 23.1 2.1 2 0 0 2 2 2 0 Spt20 family PH_4 PF15404.6 CDI76254.1 - 1.1 9.0 6.8 0.92 9.3 3.6 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain DUF2681 PF10883.8 CDI76254.1 - 1.6 9.2 25.8 0.48 10.9 11.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) C1q PF00386.21 CDI76254.1 - 1.9 8.7 8.1 0.58 10.4 3.1 2.0 2 0 0 2 2 2 0 C1q domain Connexin PF00029.19 CDI76254.1 - 2.3 7.9 6.4 4 7.1 6.4 1.6 1 1 0 1 1 1 0 Connexin OPA3 PF07047.12 CDI76254.1 - 2.4 8.0 8.7 7.7 6.3 0.1 2.1 2 0 0 2 2 2 0 Optic atrophy 3 protein (OPA3) ABC2_membrane_2 PF12679.7 CDI76254.1 - 3.4 6.9 5.8 1.6 7.9 1.1 1.9 2 0 0 2 2 2 0 ABC-2 family transporter protein DivIC PF04977.15 CDI76254.1 - 5.5 6.8 27.4 5.7 6.8 3.8 2.1 2 0 0 2 2 2 0 Septum formation initiator Rsc14 PF08586.10 CDI76254.1 - 9.7 7.1 11.4 16 6.4 6.3 2.1 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit SART-1 PF03343.13 CDI76255.1 - 0.016 13.8 22.9 0.019 13.6 22.9 1.0 1 0 0 1 1 1 0 SART-1 family rRNA_processing PF08524.11 CDI76255.1 - 0.022 14.8 27.8 0.032 14.3 27.8 1.3 1 0 0 1 1 1 0 rRNA processing U3_snoRNA_assoc PF08297.11 CDI76255.1 - 0.025 15.3 9.4 0.025 15.3 9.4 2.1 2 0 0 2 2 2 0 U3 snoRNA associated MMR1 PF08505.10 CDI76255.1 - 0.087 13.1 39.6 0.12 12.6 39.6 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein TFIIA PF03153.13 CDI76255.1 - 0.39 10.7 55.0 0.46 10.4 55.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BSP_II PF05432.11 CDI76255.1 - 0.51 10.0 30.3 0.63 9.7 30.3 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) BAF1_ABF1 PF04684.13 CDI76255.1 - 0.62 9.0 37.1 0.82 8.6 37.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4407 PF14362.6 CDI76255.1 - 0.69 9.2 27.6 0.72 9.1 27.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SMYLE_N PF18615.1 CDI76255.1 - 0.9 9.0 23.3 1.1 8.8 23.3 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Presenilin PF01080.17 CDI76255.1 - 1.2 7.9 36.8 1.7 7.4 36.8 1.3 1 0 0 1 1 1 0 Presenilin SprA-related PF12118.8 CDI76255.1 - 1.6 7.8 46.4 1.9 7.6 46.4 1.1 1 0 0 1 1 1 0 SprA-related family PA26 PF04636.13 CDI76255.1 - 2.3 7.1 22.9 2.6 6.8 22.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Spore_coat_CotO PF14153.6 CDI76255.1 - 3.6 7.5 28.9 5.2 6.9 28.9 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Activator_LAG-3 PF11498.8 CDI76255.1 - 4.3 6.2 51.2 5.7 5.8 51.2 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Suf PF05843.14 CDI76255.1 - 6.2 6.7 36.1 8.5 6.3 36.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF572 PF04502.13 CDI76255.1 - 7.2 6.1 31.5 8.8 5.8 31.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) rve PF00665.26 CDI76259.1 - 2.4e-15 56.7 0.0 5.2e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CDI76259.1 - 0.02 14.8 0.0 0.042 13.8 0.0 1.5 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDI76259.1 - 0.028 14.2 0.2 0.56 10.0 0.1 2.3 2 0 0 2 2 2 0 Integrase core domain TFIIA PF03153.13 CDI76280.1 - 0.00016 21.8 17.4 0.00016 21.8 17.4 3.1 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI76280.1 - 0.00034 20.6 0.2 0.00034 20.6 0.2 7.0 4 1 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 Trp_oprn_chp PF09534.10 CDI76280.1 - 0.0034 17.2 1.9 0.0034 17.2 1.9 4.0 4 1 0 4 4 4 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) RskA PF10099.9 CDI76280.1 - 0.095 13.0 0.1 0.095 13.0 0.1 4.8 3 2 1 4 4 4 0 Anti-sigma-K factor rskA Connexin PF00029.19 CDI76280.1 - 0.13 12.0 8.3 2.4 7.8 0.0 3.9 4 0 0 4 4 4 0 Connexin zf-4CXXC_R1 PF10497.9 CDI76293.1 - 0.00031 20.9 2.0 0.00031 20.9 2.0 1.7 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Draxin PF15550.6 CDI76293.1 - 0.14 12.0 6.4 0.17 11.7 6.4 1.1 1 0 0 1 1 1 0 Draxin DUF572 PF04502.13 CDI76293.1 - 0.19 11.3 7.4 0.25 10.9 7.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) BAF1_ABF1 PF04684.13 CDI76293.1 - 1.8 7.5 11.1 2.9 6.8 11.1 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Alg14 PF08660.11 CDI76294.1 - 1.4 8.8 5.1 2.1 8.3 5.1 1.5 1 1 0 1 1 1 0 Oligosaccharide biosynthesis protein Alg14 like SID-1_RNA_chan PF13965.6 CDI76294.1 - 3.2 6.1 6.2 3.3 6.0 6.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SWI-SNF_Ssr4 PF08549.10 CDI76294.1 - 6.6 5.2 18.6 6.7 5.2 18.6 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) TSP_1 PF00090.19 CDI76316.1 - 1.6e-107 351.5 240.7 1.4e-11 44.4 4.7 21.1 20 1 0 20 20 20 17 Thrombospondin type 1 domain Notch PF00066.17 CDI76316.1 - 1.3e-24 86.4 91.7 1.9e-07 31.4 14.0 8.7 6 0 0 6 6 6 4 LNR domain RIO1 PF01163.22 CDI76333.1 - 2.5e-10 40.3 0.0 6e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 RIO1 family RskA PF10099.9 CDI76333.1 - 0.0045 17.3 7.1 0.0087 16.4 7.1 1.4 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF668 PF05003.12 CDI76333.1 - 0.097 13.2 1.2 0.27 11.7 1.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF668) DUF3446 PF11928.8 CDI76333.1 - 0.29 11.5 42.6 1.2 9.5 10.1 3.9 4 0 0 4 4 4 0 Early growth response N-terminal domain IMUP PF15761.5 CDI76335.1 - 0.04 14.6 4.7 0.04 14.6 4.7 4.2 2 1 2 4 4 4 0 Immortalisation up-regulated protein DUF389 PF04087.14 CDI76347.1 - 0.008 16.2 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF389) PAP2 PF01569.21 CDI76347.1 - 0.039 13.7 0.1 0.039 13.7 0.1 2.5 1 1 1 2 2 2 0 PAP2 superfamily PmbA_TldD PF01523.16 CDI76347.1 - 0.21 11.4 1.0 0.3 10.9 1.0 1.3 1 0 0 1 1 1 0 Putative modulator of DNA gyrase EI24 PF07264.11 CDI76348.1 - 2.1e-08 34.6 0.1 0.0059 16.9 0.1 2.2 2 0 0 2 2 2 2 Etoposide-induced protein 2.4 (EI24) DUF2052 PF09747.9 CDI76348.1 - 1.1 9.3 22.0 2.9 8.0 14.5 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SID-1_RNA_chan PF13965.6 CDI76348.1 - 1.3 7.4 7.1 2.3 6.5 7.1 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 FAM91_C PF14648.6 CDI76348.1 - 1.4 7.7 20.9 0.043 12.6 13.0 2.0 2 0 0 2 2 2 0 FAM91 C-terminus RR_TM4-6 PF06459.12 CDI76348.1 - 1.5 8.6 22.6 0.42 10.4 14.7 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 SAPS PF04499.15 CDI76348.1 - 1.7 7.3 14.0 0.062 12.1 6.7 1.8 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.16 CDI76348.1 - 4.2 7.4 25.7 1.3 9.0 14.9 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF572 PF04502.13 CDI76348.1 - 8.4 5.9 22.2 5.7 6.5 15.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) zf-C3HC4 PF00097.25 CDI76349.1 - 0.049 13.5 1.6 0.19 11.6 1.6 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) ETRAMP PF09716.10 CDI76349.1 - 0.45 10.6 0.1 0.45 10.6 0.1 2.4 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) SARAF PF06682.12 CDI76349.1 - 3.4 7.2 32.9 4.8 6.7 32.9 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Ribosomal_60s PF00428.19 CDI76349.1 - 5.9 7.6 10.3 0.44 11.2 5.2 1.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein MAP65_ASE1 PF03999.12 CDI76360.1 - 1.6 7.3 32.9 2 7.0 32.9 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) RskA PF10099.9 CDI76363.1 - 4.9e-05 23.7 11.1 0.00022 21.6 4.6 2.9 1 1 1 2 2 2 2 Anti-sigma-K factor rskA SelP_N PF04592.14 CDI76364.1 - 0.004 16.6 12.6 0.0046 16.4 12.6 1.0 1 0 0 1 1 1 1 Selenoprotein P, N terminal region DUF1180 PF06679.12 CDI76364.1 - 0.0058 17.1 7.9 0.0075 16.7 7.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) PIP5K PF01504.18 CDI76364.1 - 0.0087 15.3 10.0 0.011 15.0 10.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase TT_ORF1 PF02956.14 CDI76364.1 - 0.021 13.5 12.5 0.024 13.3 12.5 1.0 1 0 0 1 1 1 0 TT viral orf 1 DUF908 PF06012.12 CDI76364.1 - 0.028 13.8 12.1 0.029 13.8 12.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Rtf2 PF04641.12 CDI76364.1 - 0.085 12.2 7.5 0.1 12.0 7.5 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Kei1 PF08552.11 CDI76364.1 - 0.096 12.6 8.3 0.12 12.3 8.3 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 CLN3 PF02487.17 CDI76364.1 - 0.1 11.7 8.0 0.11 11.5 8.0 1.0 1 0 0 1 1 1 0 CLN3 protein eIF-3_zeta PF05091.12 CDI76364.1 - 0.14 11.1 12.3 0.18 10.7 12.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RR_TM4-6 PF06459.12 CDI76364.1 - 0.15 11.9 10.6 0.16 11.8 10.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SKA1 PF07160.12 CDI76364.1 - 0.16 11.8 18.3 0.19 11.5 18.3 1.0 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 TAF4 PF05236.14 CDI76364.1 - 0.17 11.6 11.6 0.2 11.4 11.6 1.0 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DUF2828 PF11443.8 CDI76364.1 - 0.2 9.7 9.6 0.23 9.5 9.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Serinc PF03348.15 CDI76364.1 - 0.22 10.4 5.4 0.21 10.5 5.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ten_N PF06484.12 CDI76364.1 - 0.22 11.4 9.4 0.25 11.2 9.4 1.1 1 0 0 1 1 1 0 Teneurin Intracellular Region DUF2464 PF10240.9 CDI76364.1 - 0.25 10.9 6.2 0.26 10.8 6.2 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 MTBP_C PF14920.6 CDI76364.1 - 0.25 11.1 10.9 0.29 10.8 10.9 1.1 1 0 0 1 1 1 0 MDM2-binding DUF4366 PF14283.6 CDI76364.1 - 0.25 11.4 6.1 0.31 11.1 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) SARAF PF06682.12 CDI76364.1 - 0.31 10.7 13.9 0.35 10.5 13.9 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Presenilin PF01080.17 CDI76364.1 - 0.31 9.7 14.3 0.36 9.5 14.3 1.1 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI76364.1 - 0.31 11.0 6.8 0.35 10.8 6.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Connexin PF00029.19 CDI76364.1 - 0.31 10.7 7.7 0.41 10.4 7.7 1.2 1 0 0 1 1 1 0 Connexin SLC12 PF03522.15 CDI76364.1 - 0.32 10.0 10.5 0.32 10.0 10.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SID-1_RNA_chan PF13965.6 CDI76364.1 - 0.37 9.1 2.5 0.43 8.9 2.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RP-C_C PF11800.8 CDI76364.1 - 0.44 10.6 11.0 0.48 10.5 11.0 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Folliculin PF11704.8 CDI76364.1 - 0.6 10.0 8.1 0.81 9.5 8.1 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Pex14_N PF04695.13 CDI76364.1 - 0.62 10.7 23.4 0.74 10.4 23.4 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Neur_chan_memb PF02932.16 CDI76364.1 - 0.67 10.0 10.3 0.71 9.9 10.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CobT PF06213.12 CDI76364.1 - 0.73 9.2 19.5 1.1 8.6 19.5 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TFIIA PF03153.13 CDI76364.1 - 0.87 9.5 36.7 1.2 9.0 36.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Velvet PF11754.8 CDI76364.1 - 0.93 9.4 14.3 1 9.2 14.3 1.0 1 0 0 1 1 1 0 Velvet factor DUF2126 PF09899.9 CDI76364.1 - 0.94 7.5 8.9 0.93 7.5 8.9 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) OATP PF03137.20 CDI76364.1 - 1 7.6 4.6 1.3 7.3 4.6 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Tim54 PF11711.8 CDI76364.1 - 1.2 7.9 10.8 1.5 7.5 10.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CCDC53 PF10152.9 CDI76364.1 - 1.3 9.4 16.4 1.5 9.2 16.4 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex ALMT PF11744.8 CDI76364.1 - 1.4 7.7 10.2 1.5 7.6 10.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Membralin PF09746.9 CDI76364.1 - 1.7 7.6 8.5 2 7.4 8.5 1.0 1 0 0 1 1 1 0 Tumour-associated protein Hid1 PF12722.7 CDI76364.1 - 1.8 6.6 12.7 1.9 6.5 12.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4407 PF14362.6 CDI76364.1 - 2 7.7 11.7 2.5 7.4 11.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 CDI76364.1 - 2.2 6.1 15.4 2.7 5.8 15.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PAT1 PF09770.9 CDI76364.1 - 2.4 6.3 25.3 2.4 6.3 25.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Zip PF02535.22 CDI76364.1 - 3 7.0 8.0 3.3 6.8 8.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4746 PF15928.5 CDI76364.1 - 3 7.2 10.1 3.7 6.9 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Gti1_Pac2 PF09729.9 CDI76364.1 - 3.3 7.8 11.4 4.3 7.4 11.4 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family MDM31_MDM32 PF08118.11 CDI76364.1 - 3.5 6.2 8.0 4 6.0 8.0 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DivIC PF04977.15 CDI76364.1 - 5.8 6.8 24.3 6 6.7 12.0 2.2 2 0 0 2 2 2 0 Septum formation initiator Dicty_REP PF05086.12 CDI76364.1 - 8.4 4.2 11.6 9.4 4.1 11.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Pap_E4 PF02711.14 CDI76364.1 - 9 7.3 22.1 63 4.6 22.1 1.9 1 1 0 1 1 1 0 E4 protein GET2 PF08690.10 CDI76364.1 - 9.2 5.8 17.5 9.5 5.8 17.5 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 SRC-1 PF08832.10 CDI76372.1 - 0.18 12.9 0.2 0.68 11.0 0.2 2.0 1 1 0 1 1 1 0 Steroid receptor coactivator DUF4404 PF14357.6 CDI76376.1 - 0.0037 17.9 0.4 0.005 17.4 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4404) DUF4908 PF16252.5 CDI76376.1 - 0.074 12.6 0.4 0.07 12.7 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4908) RskA PF10099.9 CDI76388.1 - 3.5e-06 27.4 8.2 0.0005 20.4 5.7 25.2 9 7 11 20 20 20 7 Anti-sigma-K factor rskA Pribosyltran_N PF13793.6 CDI76390.1 - 5.1e-48 161.8 0.1 2.9e-47 159.4 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CDI76390.1 - 2.3e-35 122.3 1.2 4e-35 121.5 1.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CDI76390.1 - 1.4e-12 47.4 0.2 2.7e-12 46.5 0.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CDI76390.1 - 0.0019 17.7 0.0 0.0032 16.9 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase LEP503 PF15221.6 CDI76390.1 - 0.2 12.0 0.0 0.43 10.9 0.0 1.5 1 0 0 1 1 1 0 Lens epithelial cell protein LEP503 SID-1_RNA_chan PF13965.6 CDI76391.1 - 0.054 11.9 3.5 0.06 11.8 3.5 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Coat_F PF07875.12 CDI76391.1 - 0.25 11.6 12.6 0.74 10.1 3.8 2.3 1 1 1 2 2 2 0 Coat F domain CSG2 PF16965.5 CDI76391.1 - 1 8.2 5.9 1.3 7.9 5.9 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2681 PF10883.8 CDI76391.1 - 1.1 9.7 16.7 2.9 8.4 5.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) WES_acyltransf PF03007.16 CDI76391.1 - 1.3 8.8 4.9 0.31 10.8 0.7 1.9 1 1 1 2 2 2 0 Wax ester synthase-like Acyl-CoA acyltransferase domain SLC12 PF03522.15 CDI76391.1 - 2.2 7.2 16.0 3 6.8 16.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Apc15p PF05841.11 CDI76391.1 - 3 8.7 23.5 7.2 7.4 7.4 2.3 2 0 0 2 2 2 0 Apc15p protein PNISR PF15996.5 CDI76391.1 - 4.1 7.6 24.7 3.4 7.9 12.3 2.0 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR PAP1 PF08601.10 CDI76391.1 - 4.1 7.0 26.8 4.8 6.8 26.8 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 PAT1 PF09770.9 CDI76391.1 - 6.7 4.8 25.4 7.9 4.6 25.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PA26 PF04636.13 CDI76391.1 - 8.9 5.1 11.6 10 4.9 11.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) OATP PF03137.20 CDI76392.1 - 0.00025 19.5 8.4 0.00027 19.4 8.4 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family FAM176 PF14851.6 CDI76392.1 - 0.00028 20.6 7.2 0.00032 20.4 7.2 1.1 1 0 0 1 1 1 1 FAM176 family TRAP_alpha PF03896.16 CDI76392.1 - 0.00062 19.1 7.6 0.00063 19.0 7.6 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit SID-1_RNA_chan PF13965.6 CDI76392.1 - 0.00084 17.9 7.7 0.00087 17.8 7.7 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI76392.1 - 0.0019 16.2 21.0 0.0021 16.1 21.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI76392.1 - 0.0035 16.4 15.1 0.0037 16.4 15.1 1.0 1 0 0 1 1 1 1 CLN3 protein SpoIIP PF07454.11 CDI76392.1 - 0.0057 16.1 16.6 0.0057 16.1 16.6 1.0 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) tRNA_anti-like PF12869.7 CDI76392.1 - 0.0072 16.0 5.6 0.0077 15.9 5.6 1.0 1 0 0 1 1 1 1 tRNA_anti-like Ac76 PF05814.11 CDI76392.1 - 0.0083 16.1 1.6 0.0083 16.1 1.6 1.7 1 1 1 2 2 2 1 Orf76 (Ac76) CobT PF06213.12 CDI76392.1 - 0.0091 15.4 24.2 0.011 15.2 24.2 1.0 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Connexin PF00029.19 CDI76392.1 - 0.0098 15.7 13.5 0.01 15.6 13.5 1.1 1 0 0 1 1 1 1 Connexin CSG2 PF16965.5 CDI76392.1 - 0.012 14.6 10.5 0.013 14.4 10.5 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator MMM1 PF10296.9 CDI76392.1 - 0.012 14.7 8.2 0.013 14.5 8.2 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 PIP5K PF01504.18 CDI76392.1 - 0.015 14.5 17.3 0.017 14.4 17.3 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Serinc PF03348.15 CDI76392.1 - 0.02 13.9 8.8 0.02 13.8 8.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ctr PF04145.15 CDI76392.1 - 0.021 15.4 9.6 0.025 15.2 9.6 1.1 1 0 0 1 1 1 0 Ctr copper transporter family CRA PF06589.11 CDI76392.1 - 0.025 14.7 0.1 0.029 14.5 0.1 1.1 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) CBP_BcsG PF11658.8 CDI76392.1 - 0.034 12.6 15.8 0.037 12.4 15.8 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG O-antigen_lig PF13425.6 CDI76392.1 - 0.035 12.9 8.9 0.036 12.9 8.9 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CCDC53 PF10152.9 CDI76392.1 - 0.048 14.1 18.5 0.054 13.9 18.5 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex SARAF PF06682.12 CDI76392.1 - 0.049 13.3 14.5 0.054 13.1 14.5 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Ni_hydr_CYTB PF01292.20 CDI76392.1 - 0.055 13.1 0.2 0.061 12.9 0.2 1.2 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 Zip PF02535.22 CDI76392.1 - 0.064 12.5 5.6 0.075 12.2 5.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PepSY_TM PF03929.16 CDI76392.1 - 0.066 12.9 10.6 0.073 12.7 10.6 1.1 1 0 0 1 1 1 0 PepSY-associated TM region DUF4446 PF14584.6 CDI76392.1 - 0.067 13.2 12.3 0.071 13.1 12.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) TssO PF17561.2 CDI76392.1 - 0.07 13.2 17.0 0.086 12.9 17.0 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssO DUF2828 PF11443.8 CDI76392.1 - 0.081 11.0 17.6 0.091 10.8 17.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF1180 PF06679.12 CDI76392.1 - 0.084 13.3 11.0 0.1 13.0 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF913 PF06025.12 CDI76392.1 - 0.087 11.8 9.4 0.088 11.8 9.4 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Ureide_permease PF07168.11 CDI76392.1 - 0.14 10.8 5.7 0.14 10.8 5.7 1.1 1 0 0 1 1 1 0 Ureide permease KASH PF10541.9 CDI76392.1 - 0.15 12.3 4.6 0.2 11.9 4.6 1.2 1 0 0 1 1 1 0 Nuclear envelope localisation domain SLC12 PF03522.15 CDI76392.1 - 0.16 11.0 17.8 0.17 10.9 17.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Folate_carrier PF01770.18 CDI76392.1 - 0.16 10.7 10.9 0.17 10.6 10.9 1.0 1 0 0 1 1 1 0 Reduced folate carrier Baculo_PP31 PF05311.11 CDI76392.1 - 0.18 11.3 14.7 0.19 11.2 14.7 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Scs3p PF10261.9 CDI76392.1 - 0.18 11.3 9.8 0.19 11.2 9.8 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Peptidase_S49_N PF08496.10 CDI76392.1 - 0.19 11.8 15.9 0.25 11.4 15.9 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DDHD PF02862.17 CDI76392.1 - 0.21 11.7 15.3 0.24 11.5 15.3 1.1 1 0 0 1 1 1 0 DDHD domain DUF4770 PF15994.5 CDI76392.1 - 0.22 11.7 21.4 0.27 11.5 21.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Oxidored_q3 PF00499.20 CDI76392.1 - 0.24 11.1 1.8 0.33 10.7 1.8 1.4 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Acatn PF13000.7 CDI76392.1 - 0.24 9.8 3.1 0.24 9.9 3.1 1.0 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 ETRAMP PF09716.10 CDI76392.1 - 0.24 11.5 0.9 0.32 11.1 0.9 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) MLANA PF14991.6 CDI76392.1 - 0.25 11.6 4.5 0.33 11.2 4.5 1.3 1 0 0 1 1 1 0 Protein melan-A Tmemb_9 PF05434.11 CDI76392.1 - 0.26 11.1 20.5 0.31 10.9 20.5 1.0 1 0 0 1 1 1 0 TMEM9 Nucleoside_tran PF01733.18 CDI76392.1 - 0.27 10.6 6.8 0.27 10.6 6.8 1.0 1 0 0 1 1 1 0 Nucleoside transporter DUF2615 PF11027.8 CDI76392.1 - 0.28 11.4 20.3 29 4.9 20.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2615) NicO PF03824.16 CDI76392.1 - 0.31 10.3 3.5 0.34 10.2 3.5 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein Otopetrin PF03189.13 CDI76392.1 - 0.36 9.6 10.9 0.37 9.5 10.9 1.0 1 0 0 1 1 1 0 Otopetrin DUF2448 PF10476.9 CDI76392.1 - 0.42 10.5 5.3 0.46 10.3 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) BORG_CEP PF14957.6 CDI76392.1 - 0.46 11.6 12.0 0.54 11.4 12.0 1.1 1 0 0 1 1 1 0 Cdc42 effector Neur_chan_memb PF02932.16 CDI76392.1 - 0.58 10.2 14.8 0.67 10.0 14.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region OSTbeta PF15048.6 CDI76392.1 - 0.6 10.3 10.1 0.68 10.1 10.1 1.1 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein Spore_III_AF PF09581.10 CDI76392.1 - 0.61 10.1 15.8 0.7 9.9 15.8 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) Pannexin_like PF12534.8 CDI76392.1 - 0.73 8.9 13.1 0.76 8.8 13.1 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 MSP1a PF11670.8 CDI76392.1 - 0.92 8.8 2.7 1.1 8.5 2.7 1.1 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) FliP PF00813.20 CDI76392.1 - 1 9.2 15.8 1.1 9.2 15.8 1.0 1 0 0 1 1 1 0 FliP family DUF2370 PF10176.9 CDI76392.1 - 1.1 8.9 9.9 1.1 8.8 9.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Membralin PF09746.9 CDI76392.1 - 1.2 8.1 11.7 1.3 8.0 11.7 1.2 1 0 0 1 1 1 0 Tumour-associated protein OAD_gamma PF04277.13 CDI76392.1 - 1.2 9.8 4.6 5.4 7.7 4.6 1.9 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF3357 PF11837.8 CDI76392.1 - 1.4 9.4 8.5 7.3 7.1 8.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) GRP PF07172.11 CDI76392.1 - 1.4 9.6 12.4 7.8 7.3 12.4 1.9 1 1 0 1 1 1 0 Glycine rich protein family YABBY PF04690.13 CDI76392.1 - 1.6 9.3 17.9 1.8 9.1 17.9 1.1 1 0 0 1 1 1 0 YABBY protein Herpes_glycop PF01528.16 CDI76392.1 - 1.6 7.5 3.9 1.7 7.4 3.9 1.2 1 0 0 1 1 1 0 Herpesvirus glycoprotein M K_trans PF02705.16 CDI76392.1 - 1.9 6.9 5.0 2.2 6.7 5.0 1.2 1 0 0 1 1 1 0 K+ potassium transporter DUF3381 PF11861.8 CDI76392.1 - 1.9 8.3 24.0 2.3 8.0 24.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Tim54 PF11711.8 CDI76392.1 - 2 7.1 20.2 2.1 7.0 20.2 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SDF PF00375.18 CDI76392.1 - 2.1 7.3 3.3 3.4 6.6 3.3 1.5 1 1 0 1 1 1 0 Sodium:dicarboxylate symporter family Afi1 PF07792.12 CDI76392.1 - 2.1 8.8 20.3 2.5 8.6 20.3 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking EphA2_TM PF14575.6 CDI76392.1 - 2.2 9.2 22.4 7.7e+02 1.1 22.4 2.2 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PRC2_HTH_1 PF18118.1 CDI76392.1 - 2.2 9.1 13.9 3.2 8.6 13.9 1.3 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain VanZ PF04892.12 CDI76392.1 - 2.3 8.9 3.6 7.7 7.2 3.6 1.9 1 1 0 1 1 1 0 VanZ like family Velvet PF11754.8 CDI76392.1 - 2.5 8.0 20.7 2.8 7.8 20.7 1.0 1 0 0 1 1 1 0 Velvet factor HCO3_cotransp PF00955.21 CDI76392.1 - 2.8 6.7 8.5 2.8 6.7 8.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family HemX PF04375.14 CDI76392.1 - 3 7.0 47.3 3.5 6.8 47.3 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Mem_trans PF03547.18 CDI76392.1 - 3 6.1 8.9 3.1 6.1 8.9 1.0 1 0 0 1 1 1 0 Membrane transport protein DUF5308 PF17233.2 CDI76392.1 - 3.1 8.0 18.1 3.7 7.7 18.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) FPN1 PF06963.12 CDI76392.1 - 3.4 6.1 9.2 4.1 5.9 9.2 1.2 1 0 0 1 1 1 0 Ferroportin1 (FPN1) NEMP PF10225.9 CDI76392.1 - 3.8 7.1 11.3 4.3 6.9 11.3 1.1 1 0 0 1 1 1 0 NEMP family Tetraspanin PF00335.20 CDI76392.1 - 4 7.1 8.5 4.5 6.9 8.5 1.1 1 0 0 1 1 1 0 Tetraspanin family ABC2_membrane_2 PF12679.7 CDI76392.1 - 4.2 6.6 14.2 5.8 6.1 14.2 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein Endonuc_Holl PF10107.9 CDI76392.1 - 4.5 7.1 18.6 5.1 6.9 18.6 1.0 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Band_3_cyto PF07565.13 CDI76392.1 - 4.8 6.9 21.8 5.9 6.6 21.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Ndc1_Nup PF09531.10 CDI76392.1 - 5.1 5.7 17.5 5.9 5.5 17.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ALMT PF11744.8 CDI76392.1 - 6 5.6 18.4 7.1 5.3 18.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter MAPEG PF01124.18 CDI76392.1 - 6.1 6.8 5.9 8.8 6.2 5.9 1.4 1 1 0 1 1 1 0 MAPEG family UPF0565 PF10561.9 CDI76392.1 - 7 5.8 14.6 7.4 5.7 14.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 DcuA_DcuB PF03605.14 CDI76392.1 - 7.3 5.4 7.1 8.5 5.2 7.1 1.3 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Sugar_tr PF00083.24 CDI76392.1 - 7.4 5.3 5.0 7.2 5.3 5.0 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter Conotoxin PF02950.17 CDI76392.1 - 8 7.6 25.2 5e+02 1.8 25.2 2.2 1 1 0 1 1 1 0 Conotoxin DUF4638 PF15472.6 CDI76392.1 - 8.5 6.0 19.5 8.9 6.0 19.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) RskA PF10099.9 CDI76395.1 - 0.00026 21.4 22.7 0.0041 17.4 11.5 2.2 1 1 1 2 2 2 2 Anti-sigma-K factor rskA Conotoxin PF02950.17 CDI76395.1 - 0.0019 19.2 0.6 0.0019 19.2 0.6 3.6 2 1 2 4 4 4 1 Conotoxin Ribosomal_60s PF00428.19 CDI76395.1 - 0.016 15.8 8.6 0.016 15.8 8.6 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Viral_Beta_CD PF04530.12 CDI76395.1 - 0.07 13.4 0.4 0.12 12.7 0.4 1.3 1 0 0 1 1 1 0 Viral Beta C/D like family Cons_hypoth698 PF03601.14 CDI76395.1 - 0.086 11.7 0.3 0.086 11.7 0.3 2.6 3 0 0 3 3 3 0 Conserved hypothetical protein 698 RAP1 PF07218.11 CDI76395.1 - 0.097 10.9 2.8 0.14 10.4 2.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Orf78 PF06024.12 CDI76395.1 - 0.14 12.5 14.0 0.19 12.1 2.0 3.0 2 2 1 3 3 3 0 Orf78 (ac78) RAP1 PF07218.11 CDI76397.1 - 4.5 5.4 12.4 7.9 4.6 12.4 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) GT87 PF09594.10 CDI76397.1 - 8.1 6.1 16.6 15 5.2 4.4 2.6 1 1 2 3 3 3 0 Glycosyltransferase family 87 PIG-X PF08320.12 CDI76412.1 - 8.5e-07 29.1 3.4 0.0058 16.6 0.0 2.9 3 0 0 3 3 3 2 PIG-X / PBN1 K_channel_TID PF07941.11 CDI76412.1 - 0.013 15.9 9.1 0.013 15.9 9.1 8.3 5 2 3 8 8 8 0 Potassium channel Kv1.4 tandem inactivation domain RAB3GAP2_C PF14656.6 CDI76412.1 - 3.6 5.7 10.0 0.048 11.9 1.0 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit C-terminus EphA2_TM PF14575.6 CDI76412.1 - 3.9 8.4 4.9 23 6.0 0.8 3.2 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Cas1_AcylT PF07779.12 CDI76412.1 - 9 5.1 6.0 1.1 8.2 1.3 1.8 2 0 0 2 2 2 0 10 TM Acyl Transferase domain found in Cas1p DUF4400 PF14348.6 CDI76414.1 - 0.0011 18.6 0.7 0.0011 18.6 0.7 4.0 3 2 0 4 4 4 1 Domain of unknown function (DUF4400) DUF3675 PF12428.8 CDI76414.1 - 0.0023 18.5 6.2 0.0023 18.5 6.2 4.5 1 1 2 4 4 4 1 Protein of unknown function (DUF3675) SpoIIIAH PF12685.7 CDI76414.1 - 0.0023 17.8 2.0 0.0023 17.8 2.0 3.1 2 1 0 3 3 3 2 SpoIIIAH-like protein O-antigen_lig PF13425.6 CDI76414.1 - 0.0025 16.7 4.8 0.0025 16.7 4.8 2.7 1 1 1 2 2 2 1 O-antigen ligase like membrane protein TRAP_alpha PF03896.16 CDI76414.1 - 0.0051 16.1 4.6 0.0051 16.1 4.6 3.2 3 1 0 3 3 3 1 Translocon-associated protein (TRAP), alpha subunit ETRAMP PF09716.10 CDI76414.1 - 0.12 12.5 0.5 2.4 8.3 0.0 2.9 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) DUF898 PF05987.13 CDI76414.1 - 0.33 10.0 1.0 12 4.8 0.0 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF898) CRA PF06589.11 CDI76414.1 - 0.43 10.7 6.2 1.8 8.7 0.1 3.1 3 0 0 3 3 3 0 Circumsporozoite-related antigen (CRA) RXLR PF16810.5 CDI76414.1 - 7 7.1 22.6 0.24 11.8 0.8 3.2 3 1 0 3 3 3 0 RXLR phytopathogen effector protein, Avirulence activity DUF2722 PF10846.8 CDI76417.1 - 0.00043 19.4 15.1 0.00043 19.4 15.1 5.7 4 2 0 4 4 4 1 Protein of unknown function (DUF2722) DUF755 PF05501.11 CDI76417.1 - 0.0032 17.7 31.1 0.0032 17.7 31.1 6.5 6 0 0 6 6 6 1 Domain of unknown function (DUF755) Activator_LAG-3 PF11498.8 CDI76417.1 - 0.005 15.9 26.1 0.005 15.9 26.1 4.1 4 0 0 4 4 4 2 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI76417.1 - 0.0075 15.9 27.5 0.0075 15.9 27.5 4.9 4 1 0 4 4 4 2 Spt20 family SNF PF00209.18 CDI76417.1 - 0.022 13.5 3.5 0.43 9.2 2.4 2.2 2 0 0 2 2 2 0 Sodium:neurotransmitter symporter family FHIPEP PF00771.20 CDI76423.1 - 6.7 5.1 16.5 0.63 8.4 6.1 2.3 2 0 0 2 2 2 0 FHIPEP family Ribosomal_60s PF00428.19 CDI76432.1 - 0.0011 19.4 4.9 0.0011 19.4 4.9 1.6 2 0 0 2 2 1 1 60s Acidic ribosomal protein RskA PF10099.9 CDI76432.1 - 0.0017 18.7 12.0 0.0017 18.7 12.0 1.5 1 1 1 2 2 2 1 Anti-sigma-K factor rskA BAF1_ABF1 PF04684.13 CDI76432.1 - 0.0053 15.9 9.1 0.006 15.7 9.1 1.0 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor DUF2868 PF11067.8 CDI76432.1 - 0.025 14.1 15.4 0.033 13.7 15.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) DUF5427 PF10310.9 CDI76432.1 - 0.032 13.2 14.5 0.039 12.9 14.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) PCEMA1 PF07418.11 CDI76432.1 - 0.066 12.7 6.7 0.076 12.5 6.7 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 Nop53 PF07767.11 CDI76432.1 - 0.067 12.6 16.3 0.074 12.4 16.3 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Suf PF05843.14 CDI76432.1 - 0.07 13.1 16.0 0.082 12.9 16.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SID-1_RNA_chan PF13965.6 CDI76432.1 - 0.084 11.3 0.1 0.1 11.0 0.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF572 PF04502.13 CDI76432.1 - 0.12 12.0 10.2 0.14 11.7 10.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) FAM60A PF15396.6 CDI76432.1 - 0.17 11.9 5.6 0.2 11.7 5.6 1.2 1 0 0 1 1 1 0 Protein Family FAM60A THOC2_N PF16134.5 CDI76432.1 - 0.2 10.2 8.8 0.21 10.2 8.8 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Tmemb_9 PF05434.11 CDI76432.1 - 0.23 11.3 8.7 7.6 6.4 5.8 2.2 2 0 0 2 2 2 0 TMEM9 RR_TM4-6 PF06459.12 CDI76432.1 - 0.24 11.2 12.3 0.28 11.0 12.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CAF1 PF04857.20 CDI76432.1 - 0.25 10.5 5.8 0.27 10.4 5.8 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease eIF-3_zeta PF05091.12 CDI76432.1 - 0.3 10.0 12.2 0.33 9.9 12.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SpoIIP PF07454.11 CDI76432.1 - 0.42 10.0 8.7 0.54 9.7 8.7 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SLC12 PF03522.15 CDI76432.1 - 0.48 9.4 8.8 0.55 9.2 8.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Spore_coat_CotO PF14153.6 CDI76432.1 - 0.49 10.3 17.5 0.54 10.2 17.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Rtf2 PF04641.12 CDI76432.1 - 0.6 9.4 9.9 0.74 9.1 9.9 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2722 PF10846.8 CDI76432.1 - 0.82 8.5 25.5 1.5 7.7 25.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF3292 PF11696.8 CDI76432.1 - 1 7.6 9.0 1.4 7.2 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Hydin_ADK PF17213.3 CDI76432.1 - 1.2 9.3 10.0 1.6 8.9 10.0 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Podoplanin PF05808.11 CDI76432.1 - 1.2 9.2 2.8 1.7 8.8 2.8 1.1 1 0 0 1 1 1 0 Podoplanin Coilin_N PF15862.5 CDI76432.1 - 1.4 8.7 12.6 2.2 8.1 12.6 1.4 1 0 0 1 1 1 0 Coilin N-terminus Presenilin PF01080.17 CDI76432.1 - 2.2 6.9 14.8 3.6 6.2 14.8 1.3 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 CDI76432.1 - 2.5 6.8 6.0 2.6 6.8 6.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Connexin PF00029.19 CDI76432.1 - 3.2 7.4 7.9 4.5 7.0 6.6 1.7 2 0 0 2 2 2 0 Connexin DUF4446 PF14584.6 CDI76432.1 - 4 7.4 9.0 19 5.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF3138 PF11336.8 CDI76432.1 - 5.2 5.6 9.6 6.1 5.3 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) AAA_23 PF13476.6 CDI76432.1 - 6.9 7.1 17.1 9.5 6.7 17.1 1.2 1 0 0 1 1 1 0 AAA domain DUF4512 PF14975.6 CDI76432.1 - 7.1 7.5 5.8 99 3.8 5.8 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4512) Hid1 PF12722.7 CDI76432.1 - 7.5 4.5 11.3 8.7 4.3 11.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Phostensin_N PF13916.6 CDI76433.1 - 0.024 14.9 8.9 0.041 14.2 1.7 2.4 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal DUF2076 PF09849.9 CDI76433.1 - 0.052 13.6 19.9 0.44 10.6 9.2 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Activator_LAG-3 PF11498.8 CDI76433.1 - 0.09 11.7 34.8 0.13 11.2 34.8 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF5320 PF17253.2 CDI76433.1 - 0.14 13.2 0.7 0.14 13.2 0.7 2.3 2 1 0 2 2 2 0 Family of unknown function (DUF5320) Histone_HNS PF00816.21 CDI76433.1 - 0.15 12.9 3.4 5.1 8.0 0.0 2.3 2 0 0 2 2 2 0 H-NS histone family GREB1 PF15782.5 CDI76433.1 - 0.33 8.0 8.1 0.38 7.8 8.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AAA_28 PF13521.6 CDI76433.1 - 1.5 9.1 9.1 0.065 13.5 1.4 2.0 1 1 1 2 2 2 0 AAA domain DNA_pol_phi PF04931.13 CDI76435.1 - 0.001 17.3 30.2 0.001 17.3 30.2 8.4 1 1 8 9 9 9 1 DNA polymerase phi RskA PF10099.9 CDI76435.1 - 1.8 8.8 0.0 1.8 8.8 0.0 9.0 2 2 3 6 6 6 0 Anti-sigma-K factor rskA Med3 PF11593.8 CDI76438.1 - 0.11 11.7 26.4 0.16 11.2 26.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4246 PF14033.6 CDI76438.1 - 0.13 11.3 1.5 0.17 11.0 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4246) TFIIA PF03153.13 CDI76438.1 - 0.85 9.6 16.7 1 9.3 16.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI76438.1 - 0.85 9.2 7.6 0.88 9.1 7.1 1.5 2 0 0 2 2 2 0 Spt20 family SUIM_assoc PF16619.5 CDI76447.1 - 0.02 14.9 6.7 0.02 14.9 6.7 8.6 7 2 0 7 7 7 0 Unstructured region C-term to UIM in Ataxin3 Pro_isomerase PF00160.21 CDI76449.1 - 0.62 10.3 0.0 0.62 10.3 0.0 2.7 2 1 0 2 2 2 0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Tetraspanin PF00335.20 CDI76460.1 - 0.033 13.9 0.0 1.2e+02 2.3 0.0 3.7 4 1 0 4 4 4 0 Tetraspanin family Cwf_Cwc_15 PF04889.12 CDI76461.1 - 0.2 11.4 10.1 0.28 10.9 10.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein LAP1C PF05609.12 CDI76461.1 - 0.25 10.4 12.9 0.31 10.1 12.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SR-25 PF10500.9 CDI76461.1 - 0.72 9.4 45.2 6.1 6.4 43.0 2.4 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein SPX PF03105.19 CDI76461.1 - 1.5 8.6 18.5 2 8.3 18.5 1.2 1 0 0 1 1 1 0 SPX domain TFIIF_alpha PF05793.12 CDI76461.1 - 7.9 4.9 16.0 9.4 4.7 16.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4386 PF14329.6 CDI76476.1 - 0.82 9.5 13.5 1.1 9.1 13.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) Virul_Fac PF10139.9 CDI76476.1 - 6.2 4.9 18.2 7.2 4.7 18.2 1.0 1 0 0 1 1 1 0 Putative bacterial virulence factor DUF2722 PF10846.8 CDI76491.1 - 2.4e-07 30.1 23.3 1.4e-05 24.3 4.0 8.6 7 2 1 8 8 8 3 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI76491.1 - 0.0012 18.5 1.1 0.0012 18.5 1.1 8.3 4 3 2 6 6 6 1 Spt20 family SseC PF04888.12 CDI76491.1 - 0.0025 17.5 11.1 0.0025 17.5 11.1 10.5 10 2 1 11 11 11 1 Secretion system effector C (SseC) like family RskA PF10099.9 CDI76491.1 - 0.0058 17.0 17.4 0.0058 17.0 17.4 11.2 5 3 3 9 9 9 4 Anti-sigma-K factor rskA Tetraspanin PF00335.20 CDI76491.1 - 0.0061 16.3 0.0 92 2.6 0.0 3.0 2 1 0 2 2 2 0 Tetraspanin family Trp_oprn_chp PF09534.10 CDI76494.1 - 0.0002 21.2 9.3 0.00027 20.8 9.3 1.2 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Spt20 PF12090.8 CDI76494.1 - 0.00076 19.2 41.5 0.045 13.4 5.6 2.1 2 0 0 2 2 2 2 Spt20 family SMYLE_N PF18615.1 CDI76494.1 - 0.02 14.5 8.5 0.021 14.4 8.5 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Orf78 PF06024.12 CDI76494.1 - 0.021 15.1 6.2 0.029 14.7 2.0 2.1 2 0 0 2 2 2 0 Orf78 (ac78) Presenilin PF01080.17 CDI76494.1 - 0.029 13.1 12.1 0.037 12.8 12.1 1.2 1 0 0 1 1 1 0 Presenilin DUF4207 PF13904.6 CDI76494.1 - 0.062 13.0 24.6 0.079 12.6 9.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) Hamartin PF04388.12 CDI76494.1 - 0.069 11.8 12.1 0.09 11.4 12.1 1.1 1 0 0 1 1 1 0 Hamartin protein BNR_3 PF13859.6 CDI76494.1 - 0.15 11.3 4.4 0.18 11.1 4.4 1.1 1 0 0 1 1 1 0 BNR repeat-like domain BAF1_ABF1 PF04684.13 CDI76494.1 - 0.16 11.0 10.5 0.23 10.5 10.5 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CDC45 PF02724.14 CDI76494.1 - 0.17 10.1 10.4 0.2 9.9 10.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Myc_N PF01056.18 CDI76494.1 - 0.23 11.3 9.2 0.3 10.9 9.2 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Peptidase_U57 PF05582.12 CDI76494.1 - 0.24 10.6 7.6 0.3 10.3 7.6 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Peptidase_M56 PF05569.11 CDI76494.1 - 0.37 9.9 7.7 0.45 9.6 7.7 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 U1snRNP70_N PF12220.8 CDI76494.1 - 0.42 11.3 16.6 0.95 10.1 7.7 2.1 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal ORC_WH_C PF18137.1 CDI76494.1 - 0.54 10.3 10.4 0.53 10.3 6.8 2.2 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal DcuA_DcuB PF03605.14 CDI76494.1 - 0.57 9.0 8.4 0.76 8.6 8.4 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Sox_N PF12444.8 CDI76494.1 - 0.79 10.9 5.4 0.39 11.9 2.1 2.0 2 0 0 2 2 2 0 Sox developmental protein N terminal O-antigen_lig PF13425.6 CDI76494.1 - 0.93 8.2 6.8 1.2 7.9 6.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein eIF-3_zeta PF05091.12 CDI76494.1 - 1.5 7.7 18.2 0.11 11.4 8.7 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TMEM154 PF15102.6 CDI76494.1 - 1.5 8.7 11.8 4.5 7.2 11.8 1.8 1 1 0 1 1 1 0 TMEM154 protein family DUF726 PF05277.12 CDI76494.1 - 2.1 7.2 4.5 2.9 6.7 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) ATAD4 PF15321.6 CDI76494.1 - 2.3 9.6 8.2 1.3 10.4 2.1 2.2 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 SWI-SNF_Ssr4 PF08549.10 CDI76494.1 - 2.5 6.6 18.2 3.3 6.2 18.2 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Tau95_N PF17682.1 CDI76494.1 - 2.6 8.3 7.9 7.6 6.7 3.7 2.2 2 0 0 2 2 2 0 Tau95 Triple barrel domain FHIPEP PF00771.20 CDI76494.1 - 4.4 5.7 20.1 55 2.0 2.4 1.9 1 1 1 2 2 2 0 FHIPEP family PAT1 PF09770.9 CDI76494.1 - 6.4 4.9 31.5 8.5 4.5 31.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EIF4E-T PF10477.9 CDI76507.1 - 0.11 11.4 17.9 0.13 11.1 17.9 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E SMYLE_N PF18615.1 CDI76507.1 - 0.37 10.3 13.8 0.48 9.9 13.8 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain O-antigen_lig PF13425.6 CDI76507.1 - 0.49 9.1 1.5 0.63 8.8 1.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Salp15 PF12115.8 CDI76507.1 - 0.72 10.3 4.3 1.4 9.3 4.3 1.4 1 0 0 1 1 1 0 Salivary protein of 15kDa inhibits CD4+ T cell activation EphA2_TM PF14575.6 CDI76507.1 - 2 9.4 8.2 37 5.3 8.2 2.5 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ExbD PF02472.16 CDI76507.1 - 2.8 8.1 9.7 0.73 10.0 6.1 1.9 2 0 0 2 2 2 0 Biopolymer transport protein ExbD/TolR Glycos_transf_1 PF00534.20 CDI76521.1 - 6.7e-27 94.1 0.0 6.1e-25 87.7 0.0 3.0 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDI76521.1 - 7.3e-22 78.2 0.0 1.8e-21 77.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDI76521.1 - 3.6e-17 62.9 0.5 1.1e-12 48.3 0.0 3.3 2 1 1 3 3 3 2 Glycosyltransferase Family 4 Alpha-amylase_C PF02806.18 CDI76521.1 - 1.2e-14 54.6 0.0 2.8e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Glyco_trans_4_4 PF13579.6 CDI76521.1 - 1.1e-09 38.9 5.7 2.8e-08 34.4 0.8 4.4 4 1 0 4 4 4 1 Glycosyl transferase 4-like domain Alpha-amylase PF00128.24 CDI76521.1 - 1.2e-09 38.2 0.0 3.8e-06 26.7 0.0 2.5 2 1 1 3 3 3 2 Alpha amylase, catalytic domain CBM_48 PF02922.18 CDI76521.1 - 1.9e-08 34.6 0.0 1.8e-07 31.4 0.0 2.3 1 1 1 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Glyco_transf_5 PF08323.11 CDI76521.1 - 0.0026 17.5 1.0 0.05 13.3 0.1 2.6 2 1 1 3 3 3 1 Starch synthase catalytic domain Glyco_trans_1_2 PF13524.6 CDI76521.1 - 0.0046 17.3 0.0 0.014 15.7 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferases group 1 TTL PF03133.15 CDI76522.1 - 0.002 17.3 0.1 0.0033 16.6 0.1 1.4 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATG101 PF07855.12 CDI76522.1 - 0.029 14.4 0.4 0.14 12.1 0.4 1.9 1 1 0 1 1 1 0 Autophagy-related protein 101 betaPIX_CC PF16523.5 CDI76522.1 - 0.87 9.4 4.8 1.6 8.6 4.8 1.4 1 0 0 1 1 1 0 betaPIX coiled coil zf-CCCH_2 PF14608.6 CDI76523.1 - 1.1e-09 38.4 31.7 0.00013 22.3 4.8 3.5 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 CDI76523.1 - 1.1e-05 25.1 15.8 0.083 12.7 0.1 3.9 4 0 0 4 4 4 3 CCCH-type zinc finger DUF2722 PF10846.8 CDI76523.1 - 0.0027 16.7 0.1 0.0027 16.7 0.1 4.4 3 1 1 4 4 4 1 Protein of unknown function (DUF2722) Nab2p_Zf1 PF18260.1 CDI76523.1 - 0.0044 16.9 10.9 0.035 14.0 3.0 2.6 2 0 0 2 2 2 2 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 zf_CCCH_4 PF18345.1 CDI76523.1 - 0.01 15.8 21.4 0.19 11.8 0.8 4.2 3 1 1 4 4 4 0 Zinc finger domain zf-CCCH PF00642.24 CDI76523.1 - 0.013 15.4 22.4 0.013 15.4 0.7 4.0 3 1 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PWI PF01480.17 CDI76523.1 - 0.032 14.5 0.1 0.032 14.5 0.1 2.1 2 0 0 2 2 2 0 PWI domain DEDD_Tnp_IS110 PF01548.17 CDI76523.1 - 0.29 11.0 0.1 0.29 11.0 0.1 2.5 3 0 0 3 3 3 0 Transposase RAP1 PF07218.11 CDI76538.1 - 2.2 6.5 10.4 2.6 6.2 10.4 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Pep_M12B_propep PF01562.19 CDI76548.1 - 0.075 13.3 6.2 0.091 13.0 6.2 1.3 1 0 0 1 1 1 0 Reprolysin family propeptide DUF3523 PF12037.8 CDI76548.1 - 0.58 9.5 20.5 0.64 9.3 20.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) YniB PF14002.6 CDI76548.1 - 0.86 9.4 5.6 1.1 9.0 5.6 1.2 1 0 0 1 1 1 0 YniB-like protein Macoilin PF09726.9 CDI76548.1 - 1.3 7.5 16.5 1.5 7.2 16.5 1.0 1 0 0 1 1 1 0 Macoilin family VIT1 PF01988.19 CDI76548.1 - 4.5 7.1 9.5 5.4 6.8 9.5 1.0 1 0 0 1 1 1 0 VIT family BPL_N PF09825.9 CDI76548.1 - 6.5 5.7 11.0 6.9 5.6 11.0 1.0 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Miga PF10265.9 CDI76548.1 - 6.9 5.5 17.3 7.8 5.4 17.3 1.0 1 0 0 1 1 1 0 Mitoguardin Borrelia_P83 PF05262.11 CDI76548.1 - 8.9 4.7 16.8 9.1 4.6 16.8 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein TALPID3 PF15324.6 CDI76548.1 - 8.9 3.8 29.6 10 3.6 29.6 1.0 1 0 0 1 1 1 0 Hedgehog signalling target V_ATPase_I PF01496.19 CDI76569.1 - 6.7 4.5 6.1 7.2 4.4 6.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Shadoo PF14999.6 CDI76574.1 - 0.012 15.7 0.6 0.012 15.7 0.6 3.2 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective YabA PF06156.13 CDI76574.1 - 0.15 12.7 0.1 0.15 12.7 0.1 5.0 4 1 0 4 4 4 0 Initiation control protein YabA ADP_ribosyl_GH PF03747.14 CDI76574.1 - 0.42 10.3 13.8 0.061 13.0 3.8 2.5 2 1 0 2 2 2 0 ADP-ribosylglycohydrolase DUF4179 PF13786.6 CDI76574.1 - 2.4 8.7 15.4 2.9 8.4 0.3 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4179) SR-25 PF10500.9 CDI76574.1 - 6.4 6.3 43.8 1.7 8.2 5.2 3.4 2 1 0 3 3 3 0 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI76577.1 - 0.18 11.4 24.5 0.17 11.5 24.5 1.1 1 0 0 1 1 1 0 Spt20 family RskA PF10099.9 CDI76577.1 - 0.55 10.5 21.8 0.66 10.2 21.8 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI76577.1 - 0.76 10.8 6.8 0.75 10.8 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Phage_portal PF04860.12 CDI76577.1 - 0.95 8.6 8.5 1 8.5 8.5 1.0 1 0 0 1 1 1 0 Phage portal protein Pex26 PF07163.12 CDI76577.1 - 1.6 8.0 12.6 1.6 7.9 12.6 1.2 1 0 0 1 1 1 0 Pex26 protein Activator_LAG-3 PF11498.8 CDI76577.1 - 1.8 7.4 28.0 1.8 7.4 28.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Med15 PF09606.10 CDI76577.1 - 2.5 6.7 25.3 2.7 6.6 25.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Aminotran_1_2 PF00155.21 CDI76577.1 - 6.6 5.8 10.2 7.2 5.7 10.2 1.0 1 0 0 1 1 1 0 Aminotransferase class I and II Utp14 PF04615.13 CDI76578.1 - 2.3e-05 23.2 1.1 2.3e-05 23.2 1.1 4.5 2 2 2 4 4 4 2 Utp14 protein DUF2722 PF10846.8 CDI76578.1 - 0.00015 20.9 5.5 0.00015 20.9 5.5 9.7 7 3 2 9 9 9 2 Protein of unknown function (DUF2722) IspD PF01128.19 CDI76584.1 - 3.6e-13 49.8 24.0 7.1e-12 45.5 5.0 3.8 3 1 0 3 3 3 2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase SseC PF04888.12 CDI76584.1 - 0.0055 16.4 5.6 0.0055 16.4 5.6 8.1 6 3 2 8 8 8 1 Secretion system effector C (SseC) like family Ferlin_C PF16165.5 CDI76584.1 - 1.6 8.7 5.5 18 5.2 0.1 2.8 3 0 0 3 3 3 0 Ferlin C-terminus Mce4_CUP1 PF11887.8 CDI76597.1 - 0.1 12.1 3.8 0.05 13.1 0.9 1.8 1 1 1 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Exog_C PF18026.1 CDI76597.1 - 0.29 11.2 5.6 3.8 7.7 0.2 3.0 1 1 1 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain Atg14 PF10186.9 CDI76597.1 - 4.7 6.2 50.5 2.6 7.0 18.0 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HrpB7 PF09486.10 CDI76597.1 - 6.9 7.0 47.0 6.2 7.2 11.1 3.0 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF5082 PF16888.5 CDI76597.1 - 8 6.8 37.0 2 8.7 15.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) AMP-binding PF00501.28 CDI76599.1 - 0.018 13.7 0.0 0.02 13.5 0.0 1.0 1 0 0 1 1 1 0 AMP-binding enzyme Methyltransf_15 PF09445.10 CDI76606.1 - 4.8e-28 97.8 0.0 7.8e-28 97.1 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 CDI76606.1 - 0.0015 19.2 0.0 0.0047 17.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CDI76606.1 - 0.0043 16.8 0.0 0.0073 16.1 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein HSP90 PF00183.18 CDI76607.1 - 4.3e-110 369.0 0.6 2.8e-105 353.2 0.0 2.7 2 1 1 3 3 3 2 Hsp90 protein HATPase_c_3 PF13589.6 CDI76607.1 - 4.6e-10 39.5 0.0 9e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDI76607.1 - 2.5e-08 34.4 0.1 6e-08 33.2 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2183 PF09949.9 CDI76607.1 - 0.003 17.9 0.2 2.5 8.5 0.0 2.6 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2183) RskA PF10099.9 CDI76614.1 - 0.0096 16.2 12.9 0.0096 16.2 12.9 6.1 1 1 4 6 6 6 3 Anti-sigma-K factor rskA SPC25 PF06703.11 CDI76616.1 - 0.039 13.8 0.2 0.12 12.2 0.0 2.0 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) FA_desaturase PF00487.24 CDI76616.1 - 0.078 12.8 0.2 0.15 11.9 0.2 1.4 1 0 0 1 1 1 0 Fatty acid desaturase Hamartin PF04388.12 CDI76622.1 - 1.1 7.9 60.1 1.5 7.4 60.1 1.1 1 0 0 1 1 1 0 Hamartin protein UPF0020 PF01170.18 CDI76632.1 - 1.2e-05 25.1 0.1 3.8e-05 23.5 0.1 1.8 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Activator_LAG-3 PF11498.8 CDI76632.1 - 0.0048 15.9 0.2 0.0048 15.9 0.2 4.1 4 0 0 4 4 4 1 Transcriptional activator LAG-3 Mem_trans PF03547.18 CDI76632.1 - 0.065 11.6 0.0 0.088 11.2 0.0 1.3 1 0 0 1 1 1 0 Membrane transport protein DUF2722 PF10846.8 CDI76632.1 - 0.16 10.9 25.9 0.049 12.6 4.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI76632.1 - 0.72 10.0 0.0 0.72 10.0 0.0 5.4 4 1 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 NEMP PF10225.9 CDI76632.1 - 0.84 9.2 5.6 1.6 8.3 0.8 2.2 2 0 0 2 2 2 0 NEMP family DUF1645 PF07816.11 CDI76632.1 - 1.4 9.5 11.8 14 6.2 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) Lin-8 PF03353.15 CDI76632.1 - 3.2 7.2 11.7 10 5.6 0.3 2.4 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Sporozoite_P67 PF05642.11 CDI76650.1 - 0.00027 19.2 7.9 0.00027 19.2 7.9 3.5 3 1 1 4 4 4 1 Sporozoite P67 surface antigen Ribosomal_60s PF00428.19 CDI76650.1 - 0.0092 16.5 5.0 0.0092 16.5 5.0 8.4 5 2 3 8 8 8 1 60s Acidic ribosomal protein DUF4834 PF16118.5 CDI76650.1 - 0.0099 16.8 0.0 0.0099 16.8 0.0 7.6 5 1 1 6 6 6 1 Domain of unknown function (DUF4834) ANAPC4_WD40 PF12894.7 CDI76650.1 - 0.028 14.7 0.5 1.8 8.9 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Spt20 PF12090.8 CDI76655.1 - 0.00022 20.9 19.4 0.00034 20.3 19.4 1.4 1 0 0 1 1 1 1 Spt20 family PAXIP1_C PF15364.6 CDI76655.1 - 0.0017 18.7 3.2 0.0025 18.1 3.2 1.3 1 0 0 1 1 1 1 PAXIP1-associated-protein-1 C term PTIP binding protein DDHD PF02862.17 CDI76655.1 - 0.013 15.6 4.7 0.016 15.3 4.7 1.1 1 0 0 1 1 1 0 DDHD domain MecA PF05389.12 CDI76655.1 - 0.026 14.2 3.8 0.028 14.1 3.8 1.2 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) TMEM208_SND2 PF05620.11 CDI76655.1 - 0.041 13.7 0.5 0.054 13.3 0.5 1.3 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 EphA2_TM PF14575.6 CDI76655.1 - 0.52 11.2 3.2 1.2 10.0 3.2 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DivIC PF04977.15 CDI76655.1 - 3.2 7.6 15.8 6.8 6.5 15.8 1.5 1 0 0 1 1 1 0 Septum formation initiator FAM150 PF15129.6 CDI76655.1 - 3.7 7.7 11.6 2.9 8.1 9.9 1.6 2 0 0 2 2 2 0 FAM150 family DUF3464 PF11947.8 CDI76655.1 - 6.4 6.5 8.2 11 5.8 8.2 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 TFIIA PF03153.13 CDI76656.1 - 0.25 11.3 59.6 0.35 10.8 59.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 CDI76656.1 - 0.29 10.1 30.8 0.32 9.9 30.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PPP4R2 PF09184.11 CDI76656.1 - 2.6 7.6 19.4 2.8 7.4 19.4 1.2 1 0 0 1 1 1 0 PPP4R2 SR-25 PF10500.9 CDI76656.1 - 2.8 7.5 47.8 0.064 12.9 26.0 2.5 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein DUF1501 PF07394.12 CDI76656.1 - 3.2 6.7 27.0 4 6.4 27.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) FapA PF03961.13 CDI76656.1 - 3.8 6.0 14.4 4.2 5.9 14.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A CCSAP PF15748.5 CDI76656.1 - 9.4 6.3 48.3 12 5.9 48.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF1359 PF07097.11 CDI76667.1 - 0.029 14.6 0.5 0.052 13.8 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1359) DUF2052 PF09747.9 CDI76667.1 - 0.099 12.8 37.7 0.63 10.1 1.1 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) BAF1_ABF1 PF04684.13 CDI76667.1 - 2.4 7.1 30.7 3.7 6.5 30.7 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF3662 PF12401.8 CDI76668.1 - 0.0095 16.3 6.2 0.046 14.1 0.7 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF2662) HI0933_like PF03486.14 CDI76668.1 - 0.019 13.7 5.9 0.022 13.5 5.9 1.0 1 0 0 1 1 1 0 HI0933-like protein Inositol_P PF00459.25 CDI76668.1 - 0.023 14.2 6.0 0.027 14.0 6.0 1.0 1 0 0 1 1 1 0 Inositol monophosphatase family DUF4127 PF13552.6 CDI76668.1 - 0.031 12.9 4.8 0.036 12.7 4.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) AAA_32 PF13654.6 CDI76668.1 - 0.036 12.9 7.1 0.036 12.9 7.1 1.0 1 0 0 1 1 1 0 AAA domain Ofd1_CTDD PF10637.9 CDI76668.1 - 0.1 11.9 7.0 0.11 11.8 7.0 1.1 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term Tam41_Mmp37 PF09139.11 CDI76668.1 - 0.15 11.5 5.2 0.15 11.5 5.2 1.0 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial DUF2924 PF11149.8 CDI76668.1 - 0.24 11.8 6.0 0.32 11.4 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) RNase_J_C PF17770.1 CDI76668.1 - 0.26 12.4 3.9 0.37 11.9 3.9 1.3 1 0 0 1 1 1 0 Ribonuclease J C-terminal domain Spore_II_R PF09551.10 CDI76668.1 - 0.29 11.6 8.5 0.37 11.3 8.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) DUF4407 PF14362.6 CDI76668.1 - 0.34 10.2 11.8 0.35 10.2 11.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF648 PF04890.13 CDI76668.1 - 0.41 10.4 8.2 0.44 10.3 8.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF648) DUF668 PF05003.12 CDI76668.1 - 0.42 11.1 4.8 0.65 10.5 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF668) DUF445 PF04286.12 CDI76668.1 - 0.54 10.0 11.6 0.65 9.7 11.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DUF4747 PF15931.5 CDI76668.1 - 0.64 9.6 6.4 0.83 9.3 6.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4747) Asparaginase_2 PF01112.18 CDI76668.1 - 0.75 8.8 2.2 0.83 8.6 2.2 1.1 1 0 0 1 1 1 0 Asparaginase Band_7_1 PF13421.6 CDI76668.1 - 0.89 9.2 5.1 1.1 8.9 5.1 1.1 1 0 0 1 1 1 0 SPFH domain-Band 7 family Dynein_light PF01221.18 CDI76668.1 - 1.4 9.3 6.5 2.2 8.6 6.5 1.4 1 0 0 1 1 1 0 Dynein light chain type 1 Spore_III_AF PF09581.10 CDI76668.1 - 1.6 8.7 11.8 2 8.4 11.8 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) YqfD PF06898.11 CDI76668.1 - 1.9 7.2 7.1 2.9 6.6 7.1 1.3 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD Exonuc_VII_L PF02601.15 CDI76668.1 - 2.1 7.8 11.3 2.2 7.8 11.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PdaC PF13739.6 CDI76668.1 - 2.2 9.3 5.8 4 8.5 5.8 1.4 1 1 0 1 1 1 0 Deacetylase PdaC FHIPEP PF00771.20 CDI76668.1 - 2.4 6.5 11.9 2.8 6.3 11.9 1.0 1 0 0 1 1 1 0 FHIPEP family Presenilin PF01080.17 CDI76668.1 - 3.1 6.5 6.0 2.9 6.6 6.0 1.0 1 0 0 1 1 1 0 Presenilin FUSC PF04632.12 CDI76668.1 - 4.5 5.7 8.1 4.4 5.7 8.1 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family eIF-4B PF06273.11 CDI76668.1 - 5.2 6.0 6.7 5.7 5.9 6.7 1.0 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B LptE PF04390.12 CDI76668.1 - 5.7 7.7 13.5 4e+03 -1.5 13.5 2.7 1 1 0 1 1 1 0 Lipopolysaccharide-assembly DUF3589 PF12141.8 CDI76668.1 - 5.9 5.4 9.9 7 5.1 9.9 1.0 1 0 0 1 1 1 0 Beta-mannosyltransferases Endonuc_Holl PF10107.9 CDI76668.1 - 7.5 6.4 11.5 9.5 6.1 11.5 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Rad50_zn_hook PF04423.14 CDI76668.1 - 8.3 6.3 18.4 1.8e+04 -6.4 18.4 3.1 1 1 0 1 1 0 0 Rad50 zinc hook motif PepSY_TM_like_2 PF16357.5 CDI76668.1 - 8.5 6.3 10.1 11 5.9 10.1 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like Nop53 PF07767.11 CDI76671.1 - 2.2e-12 47.1 42.2 2.2e-12 47.1 42.2 9.2 4 3 5 9 9 9 3 Nop53 (60S ribosomal biogenesis) La PF05383.17 CDI76671.1 - 3.8e-10 39.7 0.1 5.1e-06 26.5 0.0 2.6 2 0 0 2 2 2 2 La domain Propeptide_C1 PF08127.13 CDI76678.1 - 0.0014 18.4 1.2 0.0025 17.6 1.2 1.4 1 0 0 1 1 1 1 Peptidase family C1 propeptide PAT1 PF09770.9 CDI76678.1 - 0.0073 14.7 25.8 0.0093 14.3 25.8 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 PTEN_C2 PF10409.9 CDI76678.1 - 0.067 12.9 0.1 0.067 12.9 0.1 3.0 2 1 0 2 2 1 0 C2 domain of PTEN tumour-suppressor protein AbLIM_anchor PF16182.5 CDI76678.1 - 0.18 11.6 15.8 0.08 12.8 0.8 2.2 2 0 0 2 2 2 0 Putative adherens-junction anchoring region of AbLIM DUF4746 PF15928.5 CDI76678.1 - 0.2 11.0 19.3 0.053 12.9 11.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Spore_coat_CotO PF14153.6 CDI76678.1 - 1 9.3 34.5 0.42 10.5 27.4 2.2 2 0 0 2 2 2 0 Spore coat protein CotO TCP PF03634.13 CDI76678.1 - 1.5 9.4 20.4 1.7 9.2 14.6 2.2 2 0 0 2 2 2 0 TCP family transcription factor Pex14_N PF04695.13 CDI76678.1 - 2 9.0 31.6 1.4 9.6 29.5 1.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MFAP1 PF06991.11 CDI76678.1 - 2.1 8.1 28.8 1.6 8.6 2.9 2.2 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing DUF4228 PF14009.6 CDI76678.1 - 2.4 8.5 8.9 0.94 9.8 4.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) CCDC53 PF10152.9 CDI76678.1 - 4 7.8 25.9 1.7 9.0 21.9 2.0 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Caldesmon PF02029.15 CDI76678.1 - 4.3 6.0 27.7 6.6 5.4 27.7 1.2 1 0 0 1 1 1 0 Caldesmon CLN3 PF02487.17 CDI76678.1 - 5.1 6.0 13.7 0.33 10.0 7.2 1.9 2 0 0 2 2 2 0 CLN3 protein LMBR1 PF04791.16 CDI76678.1 - 6.6 5.5 12.0 9.6 5.0 12.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein PTPRCAP PF15713.5 CDI76678.1 - 7.5 6.8 22.5 4.9 7.4 14.8 2.4 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated eIF-3_zeta PF05091.12 CDI76678.1 - 8.7 5.2 24.1 0.62 9.0 17.1 1.9 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CPSF100_C PF13299.6 CDI76678.1 - 9.9 6.3 20.1 19 5.4 0.3 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Glycos_transf_4 PF00953.21 CDI76686.1 - 1.2e-07 31.8 0.2 1.2e-07 31.8 0.2 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 4 RskA PF10099.9 CDI76686.1 - 2.5e-07 31.1 21.1 6.8e-06 26.5 3.5 2.6 1 1 1 2 2 2 2 Anti-sigma-K factor rskA LMBR1 PF04791.16 CDI76686.1 - 2.6e-05 23.4 8.4 3e-05 23.1 8.4 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein BAF1_ABF1 PF04684.13 CDI76686.1 - 0.00011 21.4 18.2 0.00018 20.8 18.2 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor RIFIN PF02009.16 CDI76686.1 - 0.0027 17.7 16.9 0.0036 17.2 16.9 1.1 1 0 0 1 1 1 1 Rifin eIF-3_zeta PF05091.12 CDI76686.1 - 0.0035 16.4 19.1 0.0055 15.7 19.1 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Neur_chan_memb PF02932.16 CDI76686.1 - 0.044 13.8 12.7 0.066 13.3 12.7 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ribosomal_60s PF00428.19 CDI76686.1 - 0.092 13.3 10.7 0.5 11.0 2.5 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF4175 PF13779.6 CDI76686.1 - 0.097 10.6 50.9 0.13 10.2 50.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF1682 PF07946.14 CDI76686.1 - 0.11 11.7 16.0 0.14 11.3 16.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CCSAP PF15748.5 CDI76686.1 - 0.16 12.2 20.4 0.034 14.3 13.2 2.0 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DUF3504 PF12012.8 CDI76686.1 - 0.21 11.5 14.6 1.6 8.6 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3504) DUF5523 PF17661.1 CDI76686.1 - 0.26 10.9 16.3 0.18 11.4 10.6 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5523) SID-1_RNA_chan PF13965.6 CDI76686.1 - 0.35 9.2 10.4 0.46 8.8 10.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Rrn6 PF10214.9 CDI76686.1 - 0.42 9.1 26.2 0.52 8.7 26.2 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor BPL_N PF09825.9 CDI76686.1 - 0.47 9.5 15.2 0.65 9.0 15.2 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF572 PF04502.13 CDI76686.1 - 0.57 9.7 17.2 0.82 9.2 17.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) SLC12 PF03522.15 CDI76686.1 - 0.71 8.8 21.2 1 8.3 21.2 1.2 1 0 0 1 1 1 0 Solute carrier family 12 CCDC84 PF14968.6 CDI76686.1 - 0.71 9.4 21.2 0.95 9.0 21.2 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 DUF4366 PF14283.6 CDI76686.1 - 0.96 9.5 10.0 1.1 9.2 3.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) MID_MedPIWI PF18296.1 CDI76686.1 - 1.1 9.0 22.1 1.6 8.5 22.1 1.3 1 0 0 1 1 1 0 MID domain of medPIWI MRP-S31 PF15433.6 CDI76686.1 - 1.2 8.7 26.3 1.7 8.3 26.3 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 STAC2_u1 PF16664.5 CDI76686.1 - 1.4 9.4 19.5 0.11 13.0 10.8 2.2 1 1 2 3 3 3 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 RIC3 PF15361.6 CDI76686.1 - 1.6 9.1 13.1 11 6.4 9.2 2.2 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 NARP1 PF12569.8 CDI76686.1 - 1.6 7.5 21.2 0.031 13.2 13.6 1.7 1 1 1 2 2 2 0 NMDA receptor-regulated protein 1 YjbH PF06082.11 CDI76686.1 - 2.5 6.8 17.8 3.1 6.5 17.8 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH AIF_C PF14721.6 CDI76686.1 - 2.7 8.4 16.8 0.65 10.3 8.3 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4179 PF13786.6 CDI76686.1 - 2.7 8.5 17.4 3.9 8.0 7.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4179) DcuA_DcuB PF03605.14 CDI76686.1 - 3.3 6.5 11.3 0.34 9.8 5.2 1.9 1 1 1 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter 2OG-FeII_Oxy_5 PF13759.6 CDI76686.1 - 3.9 7.9 9.9 7.9 7.0 5.2 2.2 2 0 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase DUF2367 PF10164.9 CDI76686.1 - 4.3 7.9 14.8 1.3 9.5 6.3 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2367) DUF4207 PF13904.6 CDI76686.1 - 4.5 6.9 38.6 3.2 7.4 28.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) Saw1 PF11561.8 CDI76686.1 - 5.1 6.5 18.0 0.5 9.9 11.3 2.0 2 0 0 2 2 2 0 Single strand annealing-weakened 1 MAS20 PF02064.15 CDI76686.1 - 5.6 7.1 24.0 5.5 7.1 2.0 2.4 2 0 0 2 2 2 0 MAS20 protein import receptor DUF4199 PF13858.6 CDI76686.1 - 6.5 7.1 14.1 13 6.1 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) DUF1644 PF07800.12 CDI76686.1 - 7 6.7 16.3 3.3 7.8 9.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) EMC3_TMCO1 PF01956.16 CDI76686.1 - 8.4 6.1 18.9 1.2 8.8 10.5 2.2 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like EphA2_TM PF14575.6 CDI76702.1 - 0.096 13.6 14.8 1.3 9.9 3.7 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Presenilin PF01080.17 CDI76702.1 - 0.53 9.0 20.7 0.61 8.8 20.7 1.0 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 CDI76702.1 - 0.72 10.2 22.3 0.9 9.8 22.3 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF2828 PF11443.8 CDI76702.1 - 0.75 7.8 15.7 0.86 7.6 15.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) NUC194 PF08163.12 CDI76702.1 - 0.95 8.3 16.4 1.2 8.0 16.4 1.0 1 0 0 1 1 1 0 NUC194 domain Rgp1 PF08737.10 CDI76702.1 - 1.9 7.5 19.9 2.2 7.4 19.9 1.0 1 0 0 1 1 1 0 Rgp1 PCM1_C PF15717.5 CDI76702.1 - 2 7.0 23.1 2.4 6.8 23.1 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Peptidase_S64 PF08192.11 CDI76702.1 - 2.2 6.7 19.4 2.5 6.5 19.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 RR_TM4-6 PF06459.12 CDI76702.1 - 2.2 8.0 19.2 2.7 7.7 19.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI76702.1 - 2.4 7.1 22.5 2.6 7.0 22.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PRP1_N PF06424.12 CDI76702.1 - 2.8 8.3 16.4 3.9 7.8 16.4 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Hydin_ADK PF17213.3 CDI76702.1 - 3 8.1 21.9 3.6 7.8 21.9 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain FlaG PF03646.15 CDI76702.1 - 3.1 8.0 28.7 1.3 9.3 10.8 2.3 2 0 0 2 2 2 0 FlaG protein BORG_CEP PF14957.6 CDI76702.1 - 3.5 8.8 13.0 5 8.3 13.0 1.3 1 0 0 1 1 1 0 Cdc42 effector BNR_3 PF13859.6 CDI76702.1 - 3.7 6.7 8.6 4.8 6.4 8.6 1.2 1 0 0 1 1 1 0 BNR repeat-like domain DUF1744 PF08490.12 CDI76702.1 - 4.6 5.7 16.1 0.052 12.1 5.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1744) DUF1676 PF07898.13 CDI76702.1 - 6.8 6.7 7.9 8.8 6.3 7.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) ALMT PF11744.8 CDI76702.1 - 7 5.4 19.6 7.7 5.2 19.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Senescence_reg PF04520.13 CDI76702.1 - 7 7.5 14.3 9.6 7.0 14.3 1.3 1 0 0 1 1 1 0 Senescence regulator Neur_chan_memb PF02932.16 CDI76702.1 - 8.1 6.4 15.7 12 5.8 15.7 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LAM_C PF12544.8 CDI76702.1 - 9.5 6.4 12.9 0.61 10.3 4.8 2.0 1 1 1 2 2 2 0 Lysine-2,3-aminomutase Plasmodium_Vir PF05795.11 CDI76702.1 - 9.6 5.5 12.3 12 5.2 12.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein XRN_M PF17846.1 CDI76702.1 - 9.7 5.0 17.3 11 4.8 17.3 1.0 1 0 0 1 1 1 0 Xrn1 helical domain RR_TM4-6 PF06459.12 CDI76703.1 - 3.6 7.3 26.7 3.7 7.3 26.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pannexin_like PF12534.8 CDI76703.1 - 4.1 6.4 16.0 4.4 6.3 16.0 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 VIR_N PF15912.5 CDI76703.1 - 6.7 6.2 15.8 7 6.2 15.8 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal DUF2828 PF11443.8 CDI76703.1 - 7.8 4.4 23.4 8 4.4 23.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) AAA_11 PF13086.6 CDI76703.1 - 9.6 5.9 22.2 9.7 5.9 22.2 1.0 1 0 0 1 1 1 0 AAA domain Pex14_N PF04695.13 CDI76706.1 - 0.15 12.7 31.2 0.21 12.2 31.2 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Med15 PF09606.10 CDI76706.1 - 6.8 5.2 40.6 7.8 5.0 40.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal FAM60A PF15396.6 CDI76706.1 - 9 6.2 26.6 11 6.0 26.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A TCP PF03634.13 CDI76709.1 - 8.1 7.0 26.7 12 6.4 26.7 1.3 1 0 0 1 1 1 0 TCP family transcription factor RskA PF10099.9 CDI76711.1 - 0.002 18.5 4.5 0.0028 18.0 4.5 1.5 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI76711.1 - 0.0056 17.6 7.4 0.0056 17.6 7.4 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) CytochromB561_N PF09786.9 CDI76711.1 - 0.065 12.2 19.1 0.072 12.1 19.1 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal FHIPEP PF00771.20 CDI76711.1 - 0.13 10.7 2.6 0.2 10.1 2.6 1.2 1 0 0 1 1 1 0 FHIPEP family DUF4820 PF16091.5 CDI76711.1 - 0.38 10.1 17.3 0.07 12.5 4.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF4746 PF15928.5 CDI76711.1 - 0.56 9.6 12.2 0.024 14.1 4.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Herpes_pp85 PF04637.12 CDI76711.1 - 1.8 6.9 9.4 2.6 6.4 9.4 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) RNA_pol_Rpc4 PF05132.14 CDI76711.1 - 2.1 8.7 17.8 0.54 10.7 6.6 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 CLN3 PF02487.17 CDI76711.1 - 2.5 7.1 14.1 2.7 7.0 1.6 2.0 2 0 0 2 2 2 0 CLN3 protein AIM3 PF17096.5 CDI76711.1 - 2.6 9.0 26.3 0.061 14.3 9.5 2.3 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 Baculo_PP31 PF05311.11 CDI76711.1 - 2.8 7.3 17.8 2.2 7.7 7.1 2.2 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) AIF_C PF14721.6 CDI76711.1 - 6.4 7.1 19.1 2.6 8.4 8.4 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RRM_1 PF00076.22 CDI76750.1 - 7.1e-24 83.4 0.1 7e-16 57.8 0.0 3.2 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Myf5 PF12232.8 CDI76750.1 - 0.041 14.7 0.5 0.041 14.7 0.5 4.2 4 0 0 4 4 4 0 Myogenic determination factor 5 RAP1 PF07218.11 CDI76750.1 - 5.1 5.3 11.9 7.2 4.7 11.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) TerD PF02342.18 CDI76751.1 - 1.8e-06 27.5 0.0 3.6e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 TerD domain DUF2730 PF10805.8 CDI76751.1 - 0.00042 20.4 0.5 0.001 19.2 0.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2730) DUF4600 PF15372.6 CDI76751.1 - 0.035 14.5 1.8 0.29 11.6 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) Nsp1_C PF05064.13 CDI76751.1 - 0.073 12.9 0.2 0.15 11.8 0.2 1.5 1 0 0 1 1 1 0 Nsp1-like C-terminal region FlaC_arch PF05377.11 CDI76751.1 - 0.1 13.0 2.4 0.52 10.7 0.6 2.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Helicase_C PF00271.31 CDI76752.1 - 8.7e-27 93.7 0.1 2.2e-26 92.4 0.1 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDI76754.1 - 8.5e-29 100.6 0.0 1.1e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Proteasome PF00227.26 CDI76755.1 - 2.2e-33 115.4 0.0 5.1e-18 65.2 0.0 2.2 1 1 1 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 CDI76755.1 - 1.2e-09 37.7 0.0 1.2e-09 37.7 0.0 2.5 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature ATPgrasp_YheCD PF14398.6 CDI76755.1 - 0.1 11.8 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 YheC/D like ATP-grasp RskA PF10099.9 CDI76764.1 - 0.0001 22.7 36.1 0.00062 20.1 36.1 1.9 1 1 0 1 1 1 1 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI76764.1 - 0.003 16.6 17.8 0.0036 16.4 17.8 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2722 PF10846.8 CDI76764.1 - 0.0042 16.1 27.3 0.0052 15.8 27.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) SpoIIP PF07454.11 CDI76764.1 - 0.026 14.0 15.5 0.035 13.6 15.5 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 CDI76764.1 - 0.04 13.7 11.8 0.049 13.4 11.8 1.1 1 0 0 1 1 1 0 Connexin TFIIA PF03153.13 CDI76764.1 - 0.047 13.7 39.8 0.059 13.4 39.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Activator_LAG-3 PF11498.8 CDI76764.1 - 0.061 12.3 37.3 0.069 12.1 37.3 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF4820 PF16091.5 CDI76764.1 - 0.078 12.3 10.7 0.096 12.0 10.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF913 PF06025.12 CDI76764.1 - 0.088 11.8 8.4 0.091 11.7 8.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Pap_E4 PF02711.14 CDI76764.1 - 0.1 13.5 14.2 0.18 12.8 14.2 1.3 1 0 0 1 1 1 0 E4 protein Neur_chan_memb PF02932.16 CDI76764.1 - 0.13 12.3 9.8 0.14 12.2 9.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PAT1 PF09770.9 CDI76764.1 - 0.14 10.4 25.6 0.15 10.3 25.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SID-1_RNA_chan PF13965.6 CDI76764.1 - 0.17 10.3 3.4 0.17 10.3 3.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Suf PF05843.14 CDI76764.1 - 0.18 11.8 19.0 0.21 11.6 19.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF1980 PF09323.10 CDI76764.1 - 0.18 11.7 8.1 0.19 11.6 8.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) MMR1 PF08505.10 CDI76764.1 - 0.18 12.1 17.1 0.2 11.9 17.1 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Band_3_cyto PF07565.13 CDI76764.1 - 0.19 11.5 15.9 0.24 11.2 15.9 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SLC12 PF03522.15 CDI76764.1 - 0.19 10.7 13.3 0.21 10.6 13.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 CDI76764.1 - 0.23 10.2 20.0 0.27 9.9 20.0 1.1 1 0 0 1 1 1 0 Presenilin AMP-binding PF00501.28 CDI76764.1 - 0.26 9.8 4.4 0.29 9.7 4.4 1.1 1 0 0 1 1 1 0 AMP-binding enzyme EOS1 PF12326.8 CDI76764.1 - 0.29 11.1 5.4 0.34 10.8 5.4 1.3 1 0 0 1 1 1 0 N-glycosylation protein Baculo_PP31 PF05311.11 CDI76764.1 - 0.3 10.5 11.7 0.36 10.3 11.7 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) FAM60A PF15396.6 CDI76764.1 - 0.31 11.0 10.4 0.34 10.9 10.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Velvet PF11754.8 CDI76764.1 - 0.31 10.9 14.1 0.35 10.8 14.1 1.2 1 0 0 1 1 1 0 Velvet factor CSG2 PF16965.5 CDI76764.1 - 0.31 9.9 5.2 0.29 10.0 5.2 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator UPF0560 PF10577.9 CDI76764.1 - 0.36 9.3 17.5 0.36 9.3 17.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 MDM10 PF12519.8 CDI76764.1 - 0.43 9.4 9.3 0.43 9.4 9.3 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 BAF1_ABF1 PF04684.13 CDI76764.1 - 0.47 9.4 18.3 0.63 9.0 18.3 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF572 PF04502.13 CDI76764.1 - 0.55 9.8 21.2 0.75 9.4 21.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) MCM_bind PF09739.9 CDI76764.1 - 0.56 8.6 14.1 0.65 8.4 14.1 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Folate_carrier PF01770.18 CDI76764.1 - 0.57 8.9 5.1 0.6 8.8 5.1 1.2 1 0 0 1 1 1 0 Reduced folate carrier Paf1 PF03985.13 CDI76764.1 - 0.6 9.1 20.0 0.81 8.6 20.0 1.1 1 0 0 1 1 1 0 Paf1 ALMT PF11744.8 CDI76764.1 - 0.67 8.7 10.4 0.7 8.7 10.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM176 PF14851.6 CDI76764.1 - 0.68 9.6 9.0 1.1 8.8 9.0 1.4 1 0 0 1 1 1 0 FAM176 family DUF2126 PF09899.9 CDI76764.1 - 0.69 7.9 8.7 0.68 7.9 8.7 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) FapA PF03961.13 CDI76764.1 - 0.7 8.4 8.4 0.73 8.4 8.4 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A SprA-related PF12118.8 CDI76764.1 - 0.73 8.9 36.1 0.96 8.5 36.1 1.1 1 0 0 1 1 1 0 SprA-related family CobT PF06213.12 CDI76764.1 - 0.84 9.0 28.3 1.1 8.5 28.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NEMP PF10225.9 CDI76764.1 - 1.1 8.9 6.0 1.3 8.6 6.0 1.1 1 0 0 1 1 1 0 NEMP family Serinc PF03348.15 CDI76764.1 - 1.1 8.1 8.1 1.2 8.0 8.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4770 PF15994.5 CDI76764.1 - 1.2 9.4 16.4 1.6 8.9 16.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF2828 PF11443.8 CDI76764.1 - 1.2 7.2 15.2 1.6 6.8 15.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Ferlin_C PF16165.5 CDI76764.1 - 1.2 9.1 6.5 2.1 8.3 6.5 1.4 1 0 0 1 1 1 0 Ferlin C-terminus Afi1 PF07792.12 CDI76764.1 - 1.2 9.6 13.2 1.9 9.0 13.2 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Zip PF02535.22 CDI76764.1 - 1.3 8.2 6.9 1.4 8.0 6.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 CDI76764.1 - 1.3 7.7 15.7 1.6 7.4 15.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3408 PF11888.8 CDI76764.1 - 1.4 9.1 19.6 0.27 11.3 16.2 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF3408) CDC27 PF09507.10 CDI76764.1 - 1.6 8.1 24.6 2 7.7 24.6 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Membralin PF09746.9 CDI76764.1 - 1.6 7.7 8.5 2 7.4 8.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein Hid1 PF12722.7 CDI76764.1 - 1.7 6.7 14.1 1.7 6.7 14.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LMBR1 PF04791.16 CDI76764.1 - 1.8 7.4 6.7 1.6 7.6 6.7 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein PBP1_TM PF14812.6 CDI76764.1 - 2 8.9 9.0 3 8.3 9.0 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ureide_permease PF07168.11 CDI76764.1 - 2.1 7.0 7.4 3.7 6.2 7.4 1.4 1 0 0 1 1 1 0 Ureide permease V_ATPase_I PF01496.19 CDI76764.1 - 2.3 6.1 16.3 2.8 5.8 16.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4638 PF15472.6 CDI76764.1 - 2.3 7.9 15.9 3 7.5 15.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) TFB6 PF17110.5 CDI76764.1 - 4.3 7.0 9.4 6.4 6.5 9.4 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH PBP_sp32 PF07222.12 CDI76764.1 - 4.6 6.6 17.0 5.4 6.4 17.0 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Peptidase_S15 PF02129.18 CDI76764.1 - 4.6 6.7 14.7 6.3 6.3 14.7 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Cellulose_synt PF03552.14 CDI76764.1 - 5.8 5.3 6.0 6.6 5.1 6.0 1.1 1 0 0 1 1 1 0 Cellulose synthase MIIP PF15734.5 CDI76764.1 - 5.9 6.3 18.2 6.9 6.1 18.2 1.1 1 0 0 1 1 1 0 Migration and invasion-inhibitory Asparaginase_2 PF01112.18 CDI76764.1 - 5.9 5.8 15.3 3.2 6.7 13.3 1.4 1 1 0 1 1 1 0 Asparaginase Paramyxo_ncap PF00973.19 CDI76764.1 - 6.8 5.5 13.1 8 5.2 13.1 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Plasmodium_Vir PF05795.11 CDI76764.1 - 7.3 5.9 12.1 8.7 5.6 12.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein OATP PF03137.20 CDI76764.1 - 7.7 4.7 10.2 9.3 4.4 10.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Smg8_Smg9 PF10220.9 CDI76764.1 - 7.9 4.6 17.1 8.9 4.5 17.1 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Endonuc_Holl PF10107.9 CDI76764.1 - 8.5 6.2 10.8 13 5.6 10.8 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase DDRGK PF09756.9 CDI76764.1 - 8.5 5.9 24.4 12 5.4 24.4 1.2 1 0 0 1 1 1 0 DDRGK domain Otopetrin PF03189.13 CDI76764.1 - 8.6 5.1 8.0 10 4.8 8.0 1.1 1 0 0 1 1 1 0 Otopetrin XRCC4 PF06632.12 CDI76764.1 - 8.7 5.1 19.9 11 4.7 19.9 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Abhydrolase_9_N PF15420.6 CDI76765.1 - 2.8e-05 24.2 9.1 2.8e-05 24.2 9.1 2.5 2 1 0 2 2 2 1 Alpha/beta-hydrolase family N-terminus Peptidase_S64 PF08192.11 CDI76765.1 - 0.27 9.7 3.8 0.48 8.9 3.8 1.3 1 0 0 1 1 1 0 Peptidase family S64 Oxidored_q3 PF00499.20 CDI76783.1 - 0.32 10.7 3.0 1.2 8.8 1.7 2.3 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 KASH PF10541.9 CDI76783.1 - 0.63 10.4 4.4 1.1 9.6 4.4 1.3 1 0 0 1 1 1 0 Nuclear envelope localisation domain SNARE PF05739.19 CDI76783.1 - 1.2 9.2 6.7 0.15 12.1 1.4 2.4 2 0 0 2 2 2 0 SNARE domain RskA PF10099.9 CDI76786.1 - 6.8e-05 23.2 21.4 0.0019 18.5 13.5 2.2 2 0 0 2 2 2 2 Anti-sigma-K factor rskA DUF755 PF05501.11 CDI76786.1 - 0.019 15.3 20.1 0.019 15.3 20.1 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF755) DUF572 PF04502.13 CDI76786.1 - 0.1 12.2 25.9 0.14 11.7 25.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) TFIIA PF03153.13 CDI76786.1 - 1.3 9.0 22.7 1.6 8.6 22.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI76786.1 - 1.5 8.4 51.2 0.042 13.4 17.9 2.6 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein Secretin_N_2 PF07655.13 CDI76786.1 - 4.1 8.0 41.6 1.8 9.2 18.0 2.8 3 0 0 3 3 3 0 Secretin N-terminal domain Ank_2 PF12796.7 CDI76793.1 - 2.8e-24 85.5 0.0 9.5e-14 51.8 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDI76793.1 - 4.6e-16 58.7 0.5 3.7e-07 30.3 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDI76793.1 - 5.5e-13 49.1 0.2 1.7e-09 38.0 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 CDI76793.1 - 1e-10 41.5 0.0 1.2e-05 25.5 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 CDI76793.1 - 1.8e-10 40.1 0.0 0.00073 19.8 0.0 4.5 4 1 0 4 4 4 3 Ankyrin repeat DUF2722 PF10846.8 CDI76802.1 - 0.0055 15.7 4.8 0.0065 15.5 4.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI76802.1 - 0.035 13.7 14.0 0.047 13.3 14.0 1.2 1 0 0 1 1 1 0 Spt20 family RLL PF10036.9 CDI76802.1 - 1 9.2 8.8 1.2 8.9 8.8 1.2 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein IER PF05760.12 CDI76802.1 - 1.3 9.3 18.2 1.5 9.0 18.2 1.0 1 0 0 1 1 1 0 Immediate early response protein (IER) SOBP PF15279.6 CDI76802.1 - 2.5 8.6 8.9 3.2 8.3 8.9 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4820 PF16091.5 CDI76812.1 - 0.081 12.3 5.4 0.12 11.8 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) EphA2_TM PF14575.6 CDI76812.1 - 0.15 13.0 1.3 0.26 12.2 0.5 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain eIF-3_zeta PF05091.12 CDI76812.1 - 0.17 10.8 7.0 0.19 10.6 7.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CD20 PF04103.15 CDI76812.1 - 0.18 11.9 0.2 0.28 11.2 0.2 1.3 1 0 0 1 1 1 0 CD20-like family DUF4407 PF14362.6 CDI76812.1 - 0.27 10.6 15.8 0.34 10.2 15.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Zip PF02535.22 CDI76812.1 - 0.41 9.8 7.1 0.44 9.7 7.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Serinc PF03348.15 CDI76812.1 - 0.55 9.1 4.2 0.67 8.8 4.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Neur_chan_memb PF02932.16 CDI76812.1 - 0.98 9.4 7.8 1.3 9.1 7.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region OATP PF03137.20 CDI76812.1 - 1.3 7.2 4.9 1.9 6.7 4.9 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family LPP20 PF02169.16 CDI76812.1 - 1.6 9.1 15.7 0.047 14.0 6.5 2.0 2 0 0 2 2 2 0 LPP20 lipoprotein SLC12 PF03522.15 CDI76812.1 - 1.8 7.5 8.3 2.3 7.2 8.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SelP_N PF04592.14 CDI76812.1 - 2.7 7.3 25.6 0.16 11.3 20.5 1.5 2 0 0 2 2 2 0 Selenoprotein P, N terminal region RskA PF10099.9 CDI76812.1 - 3 8.1 39.4 0.11 12.8 29.7 2.3 1 1 1 2 2 2 0 Anti-sigma-K factor rskA SARAF PF06682.12 CDI76812.1 - 3.4 7.2 11.9 5.5 6.5 11.9 1.4 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Suf PF05843.14 CDI76812.1 - 4.1 7.3 22.3 6 6.8 22.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FAP PF07174.11 CDI76812.1 - 8.4 5.7 27.8 12 5.3 27.8 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Abhydrolase_1 PF00561.20 CDI76829.1 - 4.8e-05 23.1 4.8 0.15 11.6 0.0 3.5 3 0 0 3 3 3 2 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 CDI76829.1 - 0.0071 15.9 0.2 0.024 14.2 0.2 2.0 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Suf PF05843.14 CDI76831.1 - 0.059 13.4 32.9 0.067 13.2 32.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2126 PF09899.9 CDI76831.1 - 0.65 8.0 13.7 0.83 7.7 13.7 1.3 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF572 PF04502.13 CDI76831.1 - 1 8.9 24.3 1.3 8.5 24.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Velvet PF11754.8 CDI76831.1 - 2.2 8.2 23.9 2.9 7.8 23.9 1.2 1 0 0 1 1 1 0 Velvet factor DUF4045 PF13254.6 CDI76831.1 - 3.5 7.2 23.9 4.3 6.9 23.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PNISR PF15996.5 CDI76831.1 - 3.6 7.8 34.8 4.5 7.5 34.8 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR RR_TM4-6 PF06459.12 CDI76831.1 - 4.9 6.9 26.9 7.3 6.3 26.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AUX_IAA PF02309.16 CDI76831.1 - 5.2 6.9 15.4 6.3 6.6 15.4 1.2 1 0 0 1 1 1 0 AUX/IAA family Presenilin PF01080.17 CDI76831.1 - 6.4 5.4 33.5 7.8 5.1 33.5 1.0 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI76831.1 - 6.7 6.7 21.8 8.7 6.3 21.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AF-4 PF05110.13 CDI76831.1 - 8.7 4.3 32.5 10 4.0 32.5 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Hydrolase PF00702.26 CDI76841.1 - 0.027 14.7 0.2 0.027 14.7 0.2 3.5 2 2 0 3 3 3 0 haloacid dehalogenase-like hydrolase SLC12 PF03522.15 CDI76841.1 - 3.9 6.4 55.7 0.76 8.7 26.2 2.4 2 0 0 2 2 2 0 Solute carrier family 12 RskA PF10099.9 CDI76843.1 - 0.003 17.9 29.1 0.003 17.9 29.1 5.4 1 1 4 5 5 5 3 Anti-sigma-K factor rskA PAP1 PF08601.10 CDI76843.1 - 0.0042 16.9 0.6 0.0042 16.9 0.6 3.1 1 1 2 3 3 3 2 Transcription factor PAP1 Trp_oprn_chp PF09534.10 CDI76843.1 - 0.0055 16.5 2.1 0.0055 16.5 2.1 5.2 2 1 3 5 5 5 2 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3123 PF11321.8 CDI76843.1 - 0.12 13.1 0.3 0.12 13.1 0.3 4.7 2 1 0 3 3 3 0 Protein of unknown function (DUF3123) SR-25 PF10500.9 CDI76843.1 - 0.81 9.3 31.3 0.81 9.3 11.2 3.0 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4551 PF15087.6 CDI76850.1 - 2 7.2 7.1 2.3 7.0 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SUIM_assoc PF16619.5 CDI76850.1 - 7.9 6.6 20.6 2 8.5 10.7 3.4 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI76867.1 - 8.4e-06 26.2 2.1 1.7e-05 25.2 2.1 1.4 1 1 0 1 1 1 1 Anti-sigma-K factor rskA Hid1 PF12722.7 CDI76867.1 - 0.00032 19.0 26.0 0.00039 18.7 26.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein EMC3_TMCO1 PF01956.16 CDI76867.1 - 0.0027 17.5 0.4 0.004 16.9 0.3 1.3 1 1 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like CNDH2_C PF16858.5 CDI76867.1 - 0.029 14.3 15.4 0.035 14.0 15.4 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term TFIIA PF03153.13 CDI76867.1 - 0.051 13.6 41.1 0.065 13.2 41.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Menin PF05053.13 CDI76867.1 - 0.053 11.9 25.5 0.076 11.4 25.5 1.3 1 0 0 1 1 1 0 Menin LAP1C PF05609.12 CDI76867.1 - 0.14 11.2 26.4 0.17 11.0 26.4 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GREB1 PF15782.5 CDI76867.1 - 0.17 9.0 38.8 0.2 8.8 38.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LMBR1 PF04791.16 CDI76867.1 - 0.33 9.8 13.4 0.38 9.6 13.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein RIFIN PF02009.16 CDI76867.1 - 0.46 10.3 23.8 0.61 9.9 23.8 1.0 1 0 0 1 1 1 0 Rifin SOBP PF15279.6 CDI76867.1 - 0.57 10.7 31.1 0.83 10.2 31.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Peptidase_S64 PF08192.11 CDI76867.1 - 0.95 7.9 36.3 1.1 7.7 36.3 1.2 1 0 0 1 1 1 0 Peptidase family S64 eIF-3_zeta PF05091.12 CDI76867.1 - 1.4 7.8 22.8 1.8 7.5 22.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PAT1 PF09770.9 CDI76867.1 - 1.8 6.7 28.1 2.1 6.5 28.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PA26 PF04636.13 CDI76867.1 - 2.3 7.0 19.5 2.8 6.8 19.5 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) MscS_TM PF12794.7 CDI76867.1 - 4.6 6.0 9.9 0.48 9.2 5.3 1.7 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 CDK5_activator PF03261.15 CDI76867.1 - 5.8 6.4 27.3 6.8 6.1 27.3 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Itfg2 PF15907.5 CDI76867.1 - 5.9 5.8 14.8 7.1 5.6 14.8 1.3 1 0 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 Exonuc_VII_L PF02601.15 CDI76867.1 - 6.7 6.2 24.9 8.4 5.9 24.9 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF572 PF04502.13 CDI76867.1 - 8 6.0 35.5 10 5.7 35.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Utp14 PF04615.13 CDI76867.1 - 9.6 4.6 31.5 12 4.3 31.5 1.0 1 0 0 1 1 1 0 Utp14 protein RskA PF10099.9 CDI76879.1 - 0.002 18.4 34.1 0.002 18.4 34.1 7.8 1 1 4 6 6 6 1 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI76884.1 - 0.00074 18.6 18.1 0.00074 18.6 18.1 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SR-25 PF10500.9 CDI76884.1 - 0.0014 18.3 26.6 0.03 13.9 10.3 2.2 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein Peptidase_S49_N PF08496.10 CDI76884.1 - 0.0082 16.2 11.7 0.016 15.2 11.7 1.5 1 0 0 1 1 1 1 Peptidase family S49 N-terminal DUF2126 PF09899.9 CDI76884.1 - 0.011 13.9 13.3 0.014 13.5 13.3 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Asparaginase_2 PF01112.18 CDI76884.1 - 0.047 12.7 11.7 0.052 12.6 11.7 1.1 1 0 0 1 1 1 0 Asparaginase MCU PF04678.13 CDI76884.1 - 0.088 12.9 8.4 0.11 12.6 8.4 1.4 1 0 0 1 1 1 0 Mitochondrial calcium uniporter EBP50_C PF09007.11 CDI76884.1 - 0.53 11.3 25.0 2.6 9.1 0.6 2.1 2 0 0 2 2 2 0 EBP50, C-terminal FemAB PF02388.16 CDI76884.1 - 0.81 8.5 18.4 1.2 7.9 18.4 1.2 1 0 0 1 1 1 0 FemAB family SART-1 PF03343.13 CDI76884.1 - 0.92 8.0 26.1 1.2 7.7 26.1 1.1 1 0 0 1 1 1 0 SART-1 family DUF3292 PF11696.8 CDI76884.1 - 1 7.6 17.4 1.4 7.2 17.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Radical_SAM_N PF08497.10 CDI76884.1 - 1.1 8.5 10.4 1.3 8.2 10.4 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal VIR_N PF15912.5 CDI76884.1 - 1.3 8.5 12.7 2.2 7.8 12.7 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal CPSF100_C PF13299.6 CDI76884.1 - 1.5 9.0 18.3 0.42 10.8 14.5 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal O-antigen_lig PF13425.6 CDI76884.1 - 1.6 7.4 8.0 2.1 7.0 8.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein NARP1 PF12569.8 CDI76884.1 - 1.7 7.4 19.0 2.4 6.9 19.0 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDK5_activator PF03261.15 CDI76884.1 - 1.9 8.0 22.7 2.4 7.6 22.7 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Presenilin PF01080.17 CDI76884.1 - 1.9 7.2 32.8 0.38 9.5 27.0 1.9 2 0 0 2 2 2 0 Presenilin LMBR1 PF04791.16 CDI76884.1 - 2.1 7.2 10.8 2.3 7.1 10.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein HemX PF04375.14 CDI76884.1 - 2.9 7.1 44.0 4.4 6.5 44.0 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase BORG_CEP PF14957.6 CDI76884.1 - 3.4 8.8 23.3 0.51 11.5 15.4 2.1 2 0 0 2 2 2 0 Cdc42 effector PBP1_TM PF14812.6 CDI76884.1 - 3.6 8.0 8.7 8.8 6.8 8.7 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PPL5 PF18168.1 CDI76884.1 - 4.7 6.4 18.7 1.1 8.4 14.5 1.8 2 0 0 2 2 2 0 Prim-pol family 5 Cellulose_synt PF03552.14 CDI76884.1 - 5.2 5.4 8.6 7.4 4.9 8.6 1.2 1 0 0 1 1 1 0 Cellulose synthase DAG_kinase_N PF14513.6 CDI76884.1 - 6.6 6.9 25.0 1.8 8.7 19.8 1.9 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus CBP_BcsG PF11658.8 CDI76884.1 - 7.6 4.8 16.6 9.7 4.4 16.6 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG YABBY PF04690.13 CDI76884.1 - 9.1 6.8 22.4 2.5 8.7 16.7 2.2 2 0 0 2 2 2 0 YABBY protein Helicase_RecD PF05127.14 CDI76884.1 - 10 6.0 13.5 16 5.3 13.5 1.3 1 0 0 1 1 1 0 Helicase RskA PF10099.9 CDI76890.1 - 5.7e-05 23.5 11.0 5.7e-05 23.5 11.0 6.3 2 2 3 5 5 5 1 Anti-sigma-K factor rskA Apt1 PF10351.9 CDI76890.1 - 0.00067 18.6 15.6 0.00067 18.6 15.6 3.2 2 1 0 2 2 2 1 Golgi-body localisation protein domain SPX PF03105.19 CDI76890.1 - 0.0043 17.0 18.8 0.0043 17.0 18.8 3.8 2 1 0 2 2 2 1 SPX domain SUIM_assoc PF16619.5 CDI76894.1 - 0.0022 18.0 7.3 0.0022 18.0 7.3 11.5 4 2 2 6 6 6 2 Unstructured region C-term to UIM in Ataxin3 CNDH2_C PF16858.5 CDI76894.1 - 6.9 6.5 63.3 0.35 10.7 1.5 3.4 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PhoLip_ATPase_C PF16212.5 CDI76916.1 - 8.5e-53 179.6 20.0 8.5e-53 179.6 20.0 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CDI76916.1 - 5.2e-16 58.1 0.2 1.7e-15 56.4 0.2 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CDI76916.1 - 6.1e-10 39.7 3.9 0.00016 22.0 5.6 3.9 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDI76916.1 - 4.2e-08 33.2 0.1 4.2e-07 30.0 0.0 2.6 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CDI76916.1 - 1.2e-06 28.2 4.9 3.1e-05 23.6 0.0 3.1 3 0 0 3 3 3 2 E1-E2 ATPase Tma16 PF11176.8 CDI76916.1 - 0.01 15.7 1.5 0.01 15.7 1.5 2.6 2 0 0 2 2 2 0 Translation machinery-associated protein 16 Hydrolase_3 PF08282.12 CDI76916.1 - 0.026 14.3 0.1 1.5 8.5 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF1700 PF08006.11 CDI76916.1 - 0.33 10.5 2.7 0.27 10.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) MFS_1 PF07690.16 CDI76921.1 - 4.9e-20 71.8 34.2 1.3e-19 70.4 29.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDI76921.1 - 2.3e-08 33.3 15.7 2e-05 23.7 9.3 3.1 1 1 2 3 3 3 2 Sugar (and other) transporter Nuc_H_symport PF03825.16 CDI76921.1 - 0.0067 15.5 0.7 0.011 14.7 0.7 1.3 1 0 0 1 1 1 1 Nucleoside H+ symporter MFS_1_like PF12832.7 CDI76921.1 - 0.057 12.3 7.6 0.21 10.4 4.5 2.2 2 1 0 2 2 2 0 MFS_1 like family Peptidase_U4 PF03419.13 CDI76921.1 - 0.55 9.5 5.2 1.2 8.4 5.2 1.5 1 0 0 1 1 1 0 Sporulation factor SpoIIGA ATG22 PF11700.8 CDI76921.1 - 2.1 6.9 8.8 0.28 9.8 4.0 1.8 2 0 0 2 2 2 0 Vacuole effluxer Atg22 like Methyltransf_8 PF05148.15 CDI76924.1 - 7.2e-46 156.8 0.0 1.3e-45 156.0 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 CDI76924.1 - 1.3e-06 29.0 0.0 6e-06 26.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDI76924.1 - 0.00023 21.8 0.0 0.0046 17.6 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI76924.1 - 0.011 15.5 0.0 0.52 10.1 0.0 2.5 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 CDI76924.1 - 0.12 13.1 0.0 3.3 8.5 0.0 2.8 1 1 1 2 2 2 0 Methyltransferase domain Sas10 PF09368.10 CDI76927.1 - 3.3e-21 75.5 6.1 3.3e-21 75.5 6.1 2.4 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 CDI76927.1 - 3.5e-19 69.2 2.2 3e-18 66.2 2.2 2.8 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Hydrolase PF00702.26 CDI76927.1 - 8.2 6.7 8.7 0.91 9.8 3.5 2.3 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase RRM_1 PF00076.22 CDI76931.1 - 7.1e-17 61.0 0.0 7.8e-17 60.9 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI76931.1 - 0.0023 18.0 0.0 0.0093 16.1 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 CDI76931.1 - 0.11 12.1 0.0 0.12 12.0 0.0 1.0 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rhomboid PF01694.22 CDI76932.1 - 1.2e-29 103.2 10.2 1.2e-29 103.2 10.2 2.2 2 0 0 2 2 2 1 Rhomboid family PseudoU_synth_2 PF00849.22 CDI76932.1 - 9.3e-08 32.3 0.0 1.8e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase DUF1751 PF08551.10 CDI76932.1 - 7.7e-05 23.2 0.8 0.00031 21.3 0.8 2.1 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) DER1 PF04511.15 CDI76932.1 - 0.0038 17.2 1.6 0.005 16.8 0.6 1.6 2 0 0 2 2 2 1 Der1-like family Methyltransf_28 PF02636.17 CDI76933.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase C2 PF00168.30 CDI76934.1 - 5.8e-10 39.4 0.0 1.4e-08 35.0 0.0 2.7 1 1 0 1 1 1 1 C2 domain Chorion_2 PF03964.15 CDI76934.1 - 0.00091 20.0 2.4 0.00091 20.0 2.4 5.5 4 1 1 5 5 5 1 Chorion family 2 Staphylokinase PF02821.16 CDI76934.1 - 0.04 14.4 0.3 0.27 11.7 0.0 2.2 2 0 0 2 2 2 0 Staphylokinase/Streptokinase family Transglut_core PF01841.19 CDI76934.1 - 0.084 13.3 0.2 0.25 11.8 0.2 1.7 1 0 0 1 1 1 0 Transglutaminase-like superfamily Totivirus_coat PF05518.11 CDI76935.1 - 0.017 13.2 1.4 0.026 12.6 1.4 1.2 1 0 0 1 1 1 0 Totivirus coat protein DUF1126 PF06565.12 CDI76936.1 - 8.9e-74 244.0 1.9 2.4e-31 107.6 0.2 3.4 3 0 0 3 3 3 3 DUF1126 PH-like domain TBP PF00352.21 CDI76937.1 - 5.9e-11 42.2 0.0 2e-06 27.6 0.0 2.5 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) RNA_pol_Rpb2_6 PF00562.28 CDI76939.1 - 4.4e-86 289.4 0.0 5.4e-86 289.1 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 CDI76939.1 - 1.5e-33 115.0 0.5 2.5e-33 114.3 0.5 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 SH2 PF00017.24 CDI76939.1 - 0.017 15.2 0.0 0.087 12.9 0.0 2.0 2 0 0 2 2 2 0 SH2 domain Pannexin_like PF12534.8 CDI76945.1 - 0.0014 17.8 1.1 0.0014 17.8 1.1 1.7 2 0 0 2 2 2 1 Pannexin-like TM region of LRRC8 EIIBC-GUT_N PF03612.14 CDI76945.1 - 0.014 15.1 3.0 0.014 15.1 3.0 1.8 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus LMBR1 PF04791.16 CDI76945.1 - 1.6 7.5 10.4 2.5 6.9 10.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein PRP1_N PF06424.12 CDI76945.1 - 3.5 8.0 14.6 0.57 10.6 1.5 2.2 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal AF-4 PF05110.13 CDI76946.1 - 0.079 11.0 14.9 0.094 10.8 14.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TFIIA PF03153.13 CDI76946.1 - 0.27 11.2 17.1 0.37 10.8 17.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI76946.1 - 6.7 6.3 21.8 0.24 11.0 14.6 1.8 2 0 0 2 2 2 0 Spt20 family Ribosomal_60s PF00428.19 CDI76947.1 - 0.0044 17.6 16.0 0.11 13.1 8.1 2.5 2 0 0 2 2 2 2 60s Acidic ribosomal protein DHHA1 PF02272.19 CDI76947.1 - 0.27 11.6 5.0 0.39 11.1 5.0 1.2 1 0 0 1 1 1 0 DHHA1 domain PepSY_2 PF13670.6 CDI76947.1 - 7.3 6.7 12.3 0.46 10.5 1.5 2.7 2 1 0 2 2 2 0 Peptidase propeptide and YPEB domain DUF3381 PF11861.8 CDI76950.1 - 0.0043 16.9 4.4 0.0051 16.6 4.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3381) Cwf_Cwc_15 PF04889.12 CDI76950.1 - 0.0051 16.6 0.7 0.0061 16.3 0.7 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein SR-25 PF10500.9 CDI76950.1 - 0.0087 15.7 2.1 0.0097 15.5 2.1 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein PspA_IM30 PF04012.12 CDI76950.1 - 0.016 14.8 6.4 0.016 14.8 6.4 1.6 2 0 0 2 2 2 0 PspA/IM30 family DASH_Spc19 PF08287.11 CDI76950.1 - 0.062 13.2 4.6 0.037 13.9 3.0 1.4 2 0 0 2 2 2 0 Spc19 EMP24_GP25L PF01105.24 CDI76950.1 - 0.16 11.9 0.1 0.19 11.6 0.1 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Rtf2 PF04641.12 CDI76950.1 - 0.32 10.3 6.0 0.47 9.8 6.0 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Gag_p17 PF00540.18 CDI76950.1 - 4.5 7.3 9.5 0.41 10.6 1.5 2.3 2 0 0 2 2 2 0 gag gene protein p17 (matrix protein) DUF4407 PF14362.6 CDI76950.1 - 6.5 6.0 10.0 7.9 5.7 10.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cwf_Cwc_15 PF04889.12 CDI76952.1 - 0.14 11.9 27.1 0.15 11.8 27.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein V_ATPase_I PF01496.19 CDI76952.1 - 0.33 8.8 29.5 0.36 8.7 29.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Sec62 PF03839.16 CDI76952.1 - 0.39 10.2 25.2 0.45 10.0 25.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Pex14_N PF04695.13 CDI76952.1 - 0.74 10.5 29.8 0.93 10.1 29.8 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Gti1_Pac2 PF09729.9 CDI76952.1 - 1.2 9.2 22.5 1.4 9.0 22.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family PPL5 PF18168.1 CDI76952.1 - 1.4 8.1 20.2 1.8 7.8 20.2 1.1 1 0 0 1 1 1 0 Prim-pol family 5 RR_TM4-6 PF06459.12 CDI76952.1 - 1.7 8.4 32.0 2.1 8.1 32.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NOA36 PF06524.12 CDI76952.1 - 2.1 7.6 19.2 2.6 7.3 19.2 1.0 1 0 0 1 1 1 0 NOA36 protein SMYLE_N PF18615.1 CDI76952.1 - 2.1 7.8 17.9 2.4 7.6 17.9 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain PNISR PF15996.5 CDI76952.1 - 2.1 8.6 32.7 2.7 8.2 32.7 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF4050 PF13259.6 CDI76952.1 - 2.3 8.5 22.5 2.8 8.2 22.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) DUF4746 PF15928.5 CDI76952.1 - 2.5 7.5 26.1 3.2 7.1 26.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DDRGK PF09756.9 CDI76952.1 - 3.1 7.4 40.8 4.2 6.9 40.8 1.2 1 0 0 1 1 1 0 DDRGK domain DUF4045 PF13254.6 CDI76952.1 - 3.5 7.2 24.0 3.7 7.1 24.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Presenilin PF01080.17 CDI76952.1 - 4.8 5.9 34.0 5.6 5.6 34.0 1.0 1 0 0 1 1 1 0 Presenilin PA26 PF04636.13 CDI76952.1 - 5 5.9 25.5 5.7 5.8 25.5 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) UBA_e1_thiolCys PF10585.9 CDI76952.1 - 5.1 6.9 23.6 6.3 6.6 23.6 1.1 1 0 0 1 1 1 0 Ubiquitin-activating enzyme active site FAM60A PF15396.6 CDI76952.1 - 5.3 7.0 22.3 6.4 6.7 22.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A F-protein PF00469.20 CDI76952.1 - 5.3 6.6 22.7 6.7 6.2 22.7 1.2 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef NPR3 PF03666.13 CDI76952.1 - 5.4 5.7 27.5 6.4 5.4 27.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CobT PF06213.12 CDI76952.1 - 5.4 6.3 44.4 6.1 6.1 44.4 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT ALMT PF11744.8 CDI76952.1 - 5.5 5.7 23.6 6.3 5.5 23.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Rtf2 PF04641.12 CDI76952.1 - 5.7 6.2 24.5 6.4 6.1 24.5 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger SLC12 PF03522.15 CDI76952.1 - 6.5 5.7 29.0 6.9 5.6 29.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF913 PF06025.12 CDI76952.1 - 7 5.5 18.2 8.9 5.2 18.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TFIIA PF03153.13 CDI76952.1 - 9.2 6.1 51.3 14 5.5 51.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit XRN_M PF17846.1 CDI76952.1 - 9.8 5.0 22.7 12 4.7 22.7 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Caldesmon PF02029.15 CDI76953.1 - 0.26 10.0 42.2 0.41 9.4 42.2 1.2 1 0 0 1 1 1 0 Caldesmon CCSAP PF15748.5 CDI76953.1 - 0.32 11.1 38.7 0.45 10.7 38.7 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PAT1 PF09770.9 CDI76953.1 - 0.4 8.9 61.3 0.47 8.7 61.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 CDI76953.1 - 0.89 8.3 42.2 1.2 7.8 42.2 1.2 1 0 0 1 1 1 0 Presenilin MAP7 PF05672.11 CDI76953.1 - 3.2 7.4 62.9 4.7 6.9 62.9 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family DUF4045 PF13254.6 CDI76953.1 - 3.3 7.3 35.4 4.3 6.9 35.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Hamartin PF04388.12 CDI76953.1 - 8.8 4.9 34.2 10 4.6 34.2 1.1 1 0 0 1 1 1 0 Hamartin protein CBP_BcsG PF11658.8 CDI76954.1 - 1.1e-06 27.3 10.1 1.3e-06 27.1 10.1 1.2 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG DUF4834 PF16118.5 CDI76954.1 - 1.2e-05 26.2 19.3 1.2e-05 26.2 19.3 2.8 1 1 1 2 2 1 1 Domain of unknown function (DUF4834) Peptidase_S49_N PF08496.10 CDI76954.1 - 1.4e-05 25.2 11.1 1.7e-05 24.9 11.1 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal O-antigen_lig PF13425.6 CDI76954.1 - 0.00034 19.5 5.9 0.00037 19.4 5.9 1.1 1 0 0 1 1 1 1 O-antigen ligase like membrane protein Mem_trans PF03547.18 CDI76954.1 - 0.00036 19.1 17.0 0.00045 18.7 17.0 1.2 1 0 0 1 1 1 1 Membrane transport protein V_ATPase_I PF01496.19 CDI76954.1 - 0.00063 17.8 23.8 0.00063 17.8 23.8 1.3 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF2514 PF10721.9 CDI76954.1 - 0.00076 19.5 11.5 0.00095 19.2 11.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2514) Miga PF10265.9 CDI76954.1 - 0.00091 18.3 20.8 0.0011 18.1 20.8 1.0 1 0 0 1 1 1 1 Mitoguardin NicO PF03824.16 CDI76954.1 - 0.0016 17.9 4.2 0.0019 17.6 4.2 1.2 1 0 0 1 1 1 1 High-affinity nickel-transport protein Phage_Gp23 PF10669.9 CDI76954.1 - 0.0026 18.1 4.7 0.0038 17.6 4.7 1.4 1 0 0 1 1 1 1 Protein gp23 (Bacteriophage A118) HemX PF04375.14 CDI76954.1 - 0.0029 17.0 31.4 0.0035 16.7 31.4 1.2 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase Tetraspanin PF00335.20 CDI76954.1 - 0.0033 17.2 6.1 0.0045 16.7 6.1 1.2 1 0 0 1 1 1 1 Tetraspanin family DcuC PF03606.15 CDI76954.1 - 0.0053 15.3 3.7 0.0053 15.3 3.7 2.0 1 1 1 2 2 1 1 C4-dicarboxylate anaerobic carrier YfhO PF09586.10 CDI76954.1 - 0.0054 15.0 16.8 0.0064 14.8 16.8 1.1 1 0 0 1 1 1 1 Bacterial membrane protein YfhO SLC12 PF03522.15 CDI76954.1 - 0.0075 15.3 25.7 0.0084 15.2 25.7 1.0 1 0 0 1 1 1 1 Solute carrier family 12 SARAF PF06682.12 CDI76954.1 - 0.0075 16.0 17.4 0.0075 16.0 17.4 2.1 1 1 1 2 2 1 1 SOCE-associated regulatory factor of calcium homoeostasis NARP1 PF12569.8 CDI76954.1 - 0.01 14.8 10.5 0.012 14.6 10.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SOG2 PF10428.9 CDI76954.1 - 0.013 14.8 29.5 0.013 14.7 29.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Ion_trans PF00520.31 CDI76954.1 - 0.017 14.3 0.0 0.021 14.1 0.0 1.1 1 0 0 1 1 1 0 Ion transport protein CytochromB561_N PF09786.9 CDI76954.1 - 0.018 14.1 22.4 0.021 13.9 22.4 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal Choline_transpo PF04515.12 CDI76954.1 - 0.025 13.8 3.2 0.024 13.8 2.7 1.4 1 1 0 1 1 1 0 Plasma-membrane choline transporter Wzy_C PF04932.15 CDI76954.1 - 0.028 14.1 0.3 0.043 13.4 0.3 1.4 1 1 0 1 1 1 0 O-Antigen ligase Tmp39 PF10271.9 CDI76954.1 - 0.029 13.4 7.0 0.032 13.2 7.0 1.2 1 0 0 1 1 1 0 Putative transmembrane protein FAM176 PF14851.6 CDI76954.1 - 0.041 13.5 19.8 0.49 10.0 19.8 2.1 1 1 0 1 1 1 0 FAM176 family Macoilin PF09726.9 CDI76954.1 - 0.052 12.1 38.9 0.064 11.8 38.9 1.1 1 0 0 1 1 1 0 Macoilin family DUF2561 PF10812.8 CDI76954.1 - 0.053 13.5 2.0 0.064 13.3 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2561) tRNA_anti-like PF12869.7 CDI76954.1 - 0.058 13.0 9.6 0.29 10.7 9.5 2.1 1 1 0 1 1 1 0 tRNA_anti-like DUF2828 PF11443.8 CDI76954.1 - 0.062 11.4 16.8 0.074 11.1 16.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PI3K_1B_p101 PF10486.9 CDI76954.1 - 0.067 11.0 24.5 0.079 10.7 24.5 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SID-1_RNA_chan PF13965.6 CDI76954.1 - 0.07 11.5 22.1 0.22 9.9 22.1 1.7 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 SpoIIIAH PF12685.7 CDI76954.1 - 0.07 12.9 30.9 0.13 12.1 30.9 1.5 1 1 0 1 1 1 0 SpoIIIAH-like protein CLN3 PF02487.17 CDI76954.1 - 0.072 12.1 23.4 0.19 10.7 23.4 1.7 1 1 0 1 1 1 0 CLN3 protein OAD_gamma PF04277.13 CDI76954.1 - 0.076 13.6 3.6 0.41 11.3 3.6 2.2 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF2052 PF09747.9 CDI76954.1 - 0.096 12.8 19.8 0.12 12.5 19.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Ni_hydr_CYTB PF01292.20 CDI76954.1 - 0.11 12.1 2.7 0.37 10.4 2.7 1.8 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 RAP1 PF07218.11 CDI76954.1 - 0.11 10.7 20.6 0.13 10.5 20.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4446 PF14584.6 CDI76954.1 - 0.15 12.0 13.5 0.3 11.1 13.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) FAM76 PF16046.5 CDI76954.1 - 0.17 11.2 28.7 0.25 10.7 28.7 1.3 1 0 0 1 1 1 0 FAM76 protein Plasmodium_Vir PF05795.11 CDI76954.1 - 0.17 11.3 22.4 0.21 11.0 22.4 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Nucleoside_tran PF01733.18 CDI76954.1 - 0.17 11.2 14.1 0.44 9.9 14.0 1.6 1 1 0 1 1 1 0 Nucleoside transporter DUF898 PF05987.13 CDI76954.1 - 0.24 10.4 3.4 0.1 11.7 0.9 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF898) RskA PF10099.9 CDI76954.1 - 0.25 11.6 15.2 3.1 8.1 15.1 2.0 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF4746 PF15928.5 CDI76954.1 - 0.27 10.6 13.3 0.33 10.3 13.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SCIMP PF15050.6 CDI76954.1 - 0.28 11.7 8.3 0.33 11.4 7.9 1.3 1 1 0 1 1 1 0 SCIMP protein Apt1 PF10351.9 CDI76954.1 - 0.29 9.9 32.3 0.42 9.4 32.3 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF3742 PF12553.8 CDI76954.1 - 0.3 11.2 3.6 0.8 9.8 3.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3742) SLATT_6 PF18169.1 CDI76954.1 - 0.44 10.1 7.5 0.52 9.9 7.5 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 G0-G1_switch_2 PF15103.6 CDI76954.1 - 0.45 11.0 18.0 2.3 8.7 18.0 2.0 1 1 0 1 1 1 0 G0/G1 switch protein 2 XRN_M PF17846.1 CDI76954.1 - 0.46 9.4 15.7 0.55 9.1 15.7 1.1 1 0 0 1 1 1 0 Xrn1 helical domain PA26 PF04636.13 CDI76954.1 - 0.47 9.3 16.8 0.52 9.2 16.8 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Cadherin_C_2 PF16492.5 CDI76954.1 - 0.65 10.8 14.0 3.1 8.6 14.0 2.0 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal Frizzled PF01534.17 CDI76954.1 - 0.68 8.9 6.7 1.7 7.6 6.6 1.7 1 1 0 1 1 1 0 Frizzled/Smoothened family membrane region Connexin PF00029.19 CDI76954.1 - 0.72 9.6 24.3 1.9 8.2 24.3 1.8 1 1 0 1 1 1 0 Connexin ETRAMP PF09716.10 CDI76954.1 - 0.86 9.7 3.6 0.25 11.5 0.3 2.0 1 1 1 2 2 1 0 Malarial early transcribed membrane protein (ETRAMP) Acatn PF13000.7 CDI76954.1 - 0.91 7.9 7.7 1.2 7.5 7.7 1.4 1 1 0 1 1 1 0 Acetyl-coenzyme A transporter 1 Spore_III_AF PF09581.10 CDI76954.1 - 0.95 9.5 14.5 1.7 8.7 14.5 1.5 1 1 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) PTPRCAP PF15713.5 CDI76954.1 - 1 9.7 25.7 1.4 9.2 25.7 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated ALMT PF11744.8 CDI76954.1 - 1.1 8.0 25.6 1.4 7.6 25.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Folate_carrier PF01770.18 CDI76954.1 - 1.1 7.9 19.2 0.33 9.6 15.7 1.6 1 1 1 2 2 2 0 Reduced folate carrier Endonuc_Holl PF10107.9 CDI76954.1 - 1.2 9.0 13.3 1.7 8.5 13.3 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase DUF4199 PF13858.6 CDI76954.1 - 1.2 9.5 16.0 5.2 7.4 16.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) HemY_N PF07219.13 CDI76954.1 - 1.2 9.3 8.3 4.1 7.7 8.3 1.9 1 1 0 1 1 1 0 HemY protein N-terminus MMM1 PF10296.9 CDI76954.1 - 1.2 8.1 25.8 11 4.9 25.8 1.9 1 1 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Rer1 PF03248.13 CDI76954.1 - 1.3 8.8 9.2 3.7 7.2 9.2 1.8 1 1 0 1 1 1 0 Rer1 family TT_ORF1 PF02956.14 CDI76954.1 - 1.3 7.6 19.4 1.6 7.3 19.4 1.0 1 0 0 1 1 1 0 TT viral orf 1 DDRGK PF09756.9 CDI76954.1 - 1.5 8.4 24.8 1.9 8.1 24.8 1.1 1 0 0 1 1 1 0 DDRGK domain Pex24p PF06398.11 CDI76954.1 - 1.5 7.7 11.0 2.4 7.0 10.4 1.7 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin Neur_chan_memb PF02932.16 CDI76954.1 - 1.7 8.6 32.3 2.9 7.9 32.3 1.4 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2852 PF11014.8 CDI76954.1 - 1.8 8.8 13.3 28 4.9 13.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2852) FA_desaturase PF00487.24 CDI76954.1 - 1.8 8.3 4.2 2.9 7.7 4.2 1.5 1 1 0 1 1 1 0 Fatty acid desaturase TRAP_alpha PF03896.16 CDI76954.1 - 1.9 7.6 18.1 4.5 6.4 18.1 1.7 1 1 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Draxin PF15550.6 CDI76954.1 - 2.5 7.9 21.8 3.1 7.6 21.8 1.0 1 0 0 1 1 1 0 Draxin DUF4330 PF14221.6 CDI76954.1 - 2.6 8.2 7.3 4.5 7.5 7.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4330) OSTbeta PF15048.6 CDI76954.1 - 2.7 8.2 16.1 13 5.9 16.0 2.0 1 1 0 1 1 1 0 Organic solute transporter subunit beta protein TFIIA PF03153.13 CDI76954.1 - 3 7.8 55.8 4 7.3 55.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2681 PF10883.8 CDI76954.1 - 3.7 8.0 40.8 0.21 12.0 24.5 2.3 1 1 1 2 2 1 0 Protein of unknown function (DUF2681) FA_hydroxylase PF04116.13 CDI76954.1 - 3.7 7.9 8.5 8.4 6.7 8.5 1.6 1 1 1 2 2 2 0 Fatty acid hydroxylase superfamily Peptidase_S64 PF08192.11 CDI76954.1 - 3.9 5.9 41.5 4.7 5.6 41.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 DcuA_DcuB PF03605.14 CDI76954.1 - 4.1 6.2 14.1 0.21 10.4 7.6 1.8 1 1 1 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter FAM220 PF15487.6 CDI76954.1 - 4.2 6.9 28.7 5.2 6.6 28.7 1.0 1 0 0 1 1 1 0 FAM220 family WBP-1 PF11669.8 CDI76954.1 - 4.2 8.0 21.5 8.9e+02 0.6 21.5 2.6 1 1 0 1 1 1 0 WW domain-binding protein 1 CemA PF03040.14 CDI76954.1 - 4.4 7.2 13.7 5.4 6.9 13.7 1.1 1 0 0 1 1 1 0 CemA family SRP-alpha_N PF04086.13 CDI76954.1 - 5.1 6.9 30.8 6.3 6.6 30.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TssO PF17561.2 CDI76954.1 - 5.5 7.1 20.6 11 6.1 20.5 1.6 1 1 0 1 1 1 0 Type VI secretion system, TssO Kinesin_assoc PF16183.5 CDI76954.1 - 5.8 7.0 11.0 8.4 6.5 11.0 1.4 1 0 0 1 1 1 0 Kinesin-associated Trp_oprn_chp PF09534.10 CDI76954.1 - 5.8 6.7 4.9 23 4.7 4.7 2.0 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) NST1 PF13945.6 CDI76954.1 - 5.9 7.0 46.2 8 6.5 46.2 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator FHIPEP PF00771.20 CDI76954.1 - 6 5.2 22.2 47 2.3 22.2 1.9 1 1 0 1 1 1 0 FHIPEP family CD20 PF04103.15 CDI76954.1 - 6.1 6.9 19.8 1.9e+03 -1.2 19.8 2.7 1 1 0 1 1 0 0 CD20-like family DUF4638 PF15472.6 CDI76954.1 - 7 6.3 21.1 8.7 6.0 21.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) TMEM51 PF15345.6 CDI76954.1 - 7.2 6.4 36.4 0.19 11.5 13.7 2.1 1 1 1 2 2 2 0 Transmembrane protein 51 GREB1 PF15782.5 CDI76954.1 - 7.9 3.5 40.6 9.5 3.2 40.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CRA PF06589.11 CDI76954.1 - 8.6 6.5 9.0 16 5.6 8.9 1.7 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) eIF-3_zeta PF05091.12 CDI76954.1 - 8.6 5.2 31.0 11 4.9 31.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FPN1 PF06963.12 CDI76954.1 - 8.9 4.8 14.9 23 3.4 14.9 1.7 1 1 0 1 1 1 0 Ferroportin1 (FPN1) PIG-P PF08510.12 CDI76954.1 - 9.3 6.2 7.1 44 4.0 7.1 2.2 1 1 0 1 1 1 0 PIG-P Bac_export_2 PF01312.19 CDI76954.1 - 9.3 5.4 14.2 11 5.1 14.2 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family TFIIF_alpha PF05793.12 CDI76954.1 - 10 4.6 28.3 12 4.3 28.3 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Actin PF00022.19 CDI76967.1 - 9.1e-06 24.5 0.0 9.1e-06 24.5 0.0 3.8 3 1 1 4 4 4 1 Actin TFIIA PF03153.13 CDI76967.1 - 0.00085 19.4 30.7 0.00085 19.4 30.7 3.9 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit CCSAP PF15748.5 CDI76967.1 - 0.0017 18.6 29.0 0.0017 18.6 29.0 4.1 3 1 0 3 3 3 2 Centriole, cilia and spindle-associated N6_N4_Mtase PF01555.18 CDI76967.1 - 0.045 13.5 3.2 15 5.2 3.2 3.6 1 1 0 1 1 1 0 DNA methylase RAP1 PF07218.11 CDI76967.1 - 7.6 4.7 16.7 0.091 11.0 3.3 2.2 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) PTPS PF01242.19 CDI76972.1 - 7.2e-09 35.7 3.7 2.7e-05 24.1 0.1 2.8 2 1 1 3 3 2 2 6-pyruvoyl tetrahydropterin synthase TFIIA PF03153.13 CDI76972.1 - 0.00021 21.4 23.6 0.00028 21.0 23.6 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF3246 PF11596.8 CDI76972.1 - 0.016 14.6 4.6 0.027 13.9 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Ndc1_Nup PF09531.10 CDI76972.1 - 0.062 12.0 7.1 0.071 11.8 7.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TERB2 PF15101.6 CDI76972.1 - 0.074 13.1 14.7 0.15 12.1 14.7 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Band_3_cyto PF07565.13 CDI76972.1 - 0.15 11.8 5.3 0.18 11.6 5.3 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SLC12 PF03522.15 CDI76972.1 - 0.21 10.5 5.5 0.25 10.3 5.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 FAM176 PF14851.6 CDI76972.1 - 0.5 10.0 10.2 6.6 6.4 5.5 2.2 2 0 0 2 2 2 0 FAM176 family Spt20 PF12090.8 CDI76972.1 - 0.83 9.2 34.1 1.9 8.0 33.6 1.7 2 0 0 2 2 2 0 Spt20 family Tim54 PF11711.8 CDI76972.1 - 0.99 8.1 9.0 0.79 8.4 6.9 1.7 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF4770 PF15994.5 CDI76972.1 - 1 9.6 9.1 1.7 8.8 9.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) PBP1_TM PF14812.6 CDI76972.1 - 1 9.8 5.6 7.4 7.0 0.5 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GREB1 PF15782.5 CDI76972.1 - 1.3 6.1 12.8 1.5 5.8 12.8 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PAT1 PF09770.9 CDI76972.1 - 1.3 7.2 18.6 1.9 6.7 18.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Rrn6 PF10214.9 CDI76972.1 - 1.8 7.0 18.3 2.2 6.7 18.3 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Lin-8 PF03353.15 CDI76972.1 - 1.8 8.0 14.0 3.5 7.1 14.0 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Peptidase_S8 PF00082.22 CDI76972.1 - 2.3 7.4 17.9 3.8 6.7 17.9 1.4 1 1 0 1 1 1 0 Subtilase family AF-4 PF05110.13 CDI76972.1 - 2.3 6.2 22.9 3.2 5.7 22.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Peptidase_S64 PF08192.11 CDI76972.1 - 3 6.2 12.0 4 5.8 12.0 1.2 1 0 0 1 1 1 0 Peptidase family S64 DUF3306 PF11748.8 CDI76972.1 - 3.4 8.5 16.8 9 7.2 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) DUF4834 PF16118.5 CDI76972.1 - 3.5 8.6 12.5 8.3 7.4 12.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3245 PF11595.8 CDI76972.1 - 3.8 8.0 19.2 0.11 12.9 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) ALMT PF11744.8 CDI76972.1 - 4.9 5.9 7.2 7.4 5.3 7.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Connexin PF00029.19 CDI76972.1 - 6.8 6.4 8.9 1.7 8.3 5.9 1.5 2 0 0 2 2 1 0 Connexin DUF5321 PF17254.2 CDI76972.1 - 7.4 6.0 11.4 17 4.8 11.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5321) DUF719 PF05334.13 CDI76972.1 - 9.2 6.4 12.2 1 9.6 7.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF719) PepSY_TM PF03929.16 CDI76972.1 - 9.5 5.8 11.9 19 4.8 6.5 2.1 2 0 0 2 2 2 0 PepSY-associated TM region EFTUD2 PF16004.5 CDI76975.1 - 0.053 14.1 2.3 0.053 14.1 2.3 2.1 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus DUF5523 PF17661.1 CDI76975.1 - 0.68 9.6 34.3 0.89 9.2 34.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Presenilin PF01080.17 CDI76975.1 - 1.5 7.5 36.2 2.1 7.0 36.2 1.2 1 0 0 1 1 1 0 Presenilin DUF4667 PF15700.5 CDI76975.1 - 2.2 8.3 28.2 2.8 8.0 28.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) G0-G1_switch_2 PF15103.6 CDI76975.1 - 2.2 8.8 27.3 1.4 9.4 2.6 2.1 2 0 0 2 2 2 0 G0/G1 switch protein 2 PPP4R2 PF09184.11 CDI76975.1 - 3.3 7.2 23.3 3.6 7.1 23.3 1.0 1 0 0 1 1 1 0 PPP4R2 DUF4484 PF14831.6 CDI76975.1 - 8.4 6.4 27.8 8.3 6.4 3.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) PBP PF01161.20 CDI76985.1 - 1.8e-17 63.9 0.0 1.8e-17 63.9 0.0 2.0 2 1 0 2 2 1 1 Phosphatidylethanolamine-binding protein TFIIA PF03153.13 CDI76985.1 - 0.00011 22.4 53.9 0.0049 16.9 37.1 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit SpoIIP PF07454.11 CDI76985.1 - 0.0099 15.4 11.3 0.0099 15.4 11.3 2.1 2 0 0 2 2 2 1 Stage II sporulation protein P (SpoIIP) Spt20 PF12090.8 CDI76985.1 - 0.022 14.4 11.1 0.022 14.4 11.1 3.1 2 1 1 3 3 1 0 Spt20 family SPX PF03105.19 CDI76985.1 - 0.1 12.5 16.8 0.15 12.0 16.8 1.2 1 0 0 1 1 1 0 SPX domain Spem1 PF15670.5 CDI76985.1 - 0.11 12.0 17.8 0.03 13.9 11.0 2.0 2 0 0 2 2 2 0 Spermatid maturation protein 1 DUF5523 PF17661.1 CDI76985.1 - 0.16 11.7 22.8 0.085 12.5 14.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Presenilin PF01080.17 CDI76985.1 - 0.25 10.1 26.7 0.76 8.5 21.0 2.1 2 0 0 2 2 2 0 Presenilin RP-C_C PF11800.8 CDI76985.1 - 0.37 10.9 16.6 0.23 11.6 10.5 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region CPSF100_C PF13299.6 CDI76985.1 - 0.37 11.0 18.1 1.5 9.0 12.1 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal eIF-3_zeta PF05091.12 CDI76985.1 - 0.44 9.5 28.2 1.7 7.5 20.8 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3527 PF12043.8 CDI76985.1 - 0.63 9.6 15.1 0.072 12.6 8.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3527) Lin-8 PF03353.15 CDI76985.1 - 0.74 9.3 29.2 0.023 14.3 16.3 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist PIP5K PF01504.18 CDI76985.1 - 0.79 8.9 17.4 11 5.2 0.0 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Connexin PF00029.19 CDI76985.1 - 1.4 8.6 16.3 0.8 9.4 10.0 2.1 2 0 0 2 2 2 0 Connexin Gti1_Pac2 PF09729.9 CDI76985.1 - 1.7 8.7 19.2 11 6.0 15.3 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family DUF2828 PF11443.8 CDI76985.1 - 1.8 6.6 18.8 1.2 7.2 13.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) DUF2052 PF09747.9 CDI76985.1 - 2 8.5 25.7 3.8 7.6 19.7 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) GAGA_bind PF06217.12 CDI76985.1 - 2.3 8.4 17.7 0.95 9.7 11.5 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family FYDLN_acid PF09538.10 CDI76985.1 - 2.4 8.9 15.2 13 6.6 11.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Dicty_REP PF05086.12 CDI76985.1 - 2.6 5.9 13.0 0.12 10.4 6.6 1.7 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein SLC12 PF03522.15 CDI76985.1 - 2.7 6.9 23.0 4.1 6.3 17.5 2.0 2 0 0 2 2 2 0 Solute carrier family 12 FAM60A PF15396.6 CDI76985.1 - 2.9 7.8 19.6 10 6.0 15.4 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Bul1_N PF04425.12 CDI76985.1 - 3.1 6.5 20.1 0.13 11.0 11.2 2.0 2 0 0 2 2 2 0 Bul1 N terminus Endostatin PF06482.11 CDI76985.1 - 3.2 7.1 22.1 8.2 5.8 17.6 2.1 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin MDM10 PF12519.8 CDI76985.1 - 3.4 6.4 17.5 1.9 7.3 12.3 2.0 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 DUF1180 PF06679.12 CDI76985.1 - 3.7 7.9 9.8 2.2 8.7 5.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Peptidase_S64 PF08192.11 CDI76985.1 - 3.9 5.9 17.5 0.19 10.2 9.6 1.9 2 0 0 2 2 2 0 Peptidase family S64 Cellulose_synt PF03552.14 CDI76985.1 - 4.2 5.7 8.5 16 3.8 5.3 2.0 2 0 0 2 2 2 0 Cellulose synthase Peptidase_U57 PF05582.12 CDI76985.1 - 4.8 6.4 11.8 0.19 10.9 3.2 2.2 2 0 0 2 2 2 0 YabG peptidase U57 Sec62 PF03839.16 CDI76985.1 - 5.5 6.4 19.7 10 5.5 14.6 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 DUF908 PF06012.12 CDI76985.1 - 5.7 6.2 21.5 3.1 7.1 14.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) CCSAP PF15748.5 CDI76985.1 - 6.5 6.8 28.0 24 5.0 0.2 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated SARAF PF06682.12 CDI76985.1 - 7.7 6.1 31.8 0.81 9.3 0.4 2.1 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Exonuc_VII_L PF02601.15 CDI76985.1 - 8.9 5.8 21.9 4.1 6.9 14.7 2.0 2 0 0 2 2 2 0 Exonuclease VII, large subunit Pex14_N PF04695.13 CDI76985.1 - 9.7 6.8 48.4 3 8.5 4.1 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 CDI76987.1 - 0.0012 18.9 7.2 0.0012 18.9 7.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI76987.1 - 0.0015 17.5 0.9 0.0015 17.5 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) WTX PF09422.10 CDI76987.1 - 0.024 13.7 2.0 0.025 13.7 2.0 1.0 1 0 0 1 1 1 0 WTX protein Spt20 PF12090.8 CDI76987.1 - 0.043 13.4 12.9 0.067 12.8 12.9 1.2 1 0 0 1 1 1 0 Spt20 family SKA1 PF07160.12 CDI76987.1 - 0.057 13.3 2.6 0.077 12.8 2.6 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Sulfotransfer_3 PF13469.6 CDI76987.1 - 0.065 13.6 1.0 0.083 13.3 1.0 1.1 1 0 0 1 1 1 0 Sulfotransferase family UPF0565 PF10561.9 CDI76987.1 - 0.17 11.1 0.7 0.16 11.1 0.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 ACDC PF14733.6 CDI76987.1 - 0.25 11.7 1.9 15 6.0 1.8 2.2 2 0 0 2 2 2 0 AP2-coincident C-terminal BAF1_ABF1 PF04684.13 CDI76987.1 - 0.35 9.9 5.4 0.35 9.9 5.4 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Presenilin PF01080.17 CDI76987.1 - 0.84 8.3 2.6 0.98 8.1 2.6 1.1 1 0 0 1 1 1 0 Presenilin CCDC53 PF10152.9 CDI76987.1 - 1 9.7 6.2 1.8 9.0 6.2 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex SUIM_assoc PF16619.5 CDI76987.1 - 1.2 9.3 12.2 3.8 7.7 12.2 1.9 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Tic110 PF16940.5 CDI76987.1 - 3.2 6.2 11.3 3.8 5.9 11.3 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF3138 PF11336.8 CDI76987.1 - 3.4 6.2 19.8 4.5 5.8 19.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Kei1 PF08552.11 CDI76987.1 - 3.7 7.4 6.1 5.7 6.8 6.1 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 FRQ PF09421.10 CDI76987.1 - 4.4 5.2 7.5 5.6 4.8 7.5 1.0 1 0 0 1 1 1 0 Frequency clock protein DUF1180 PF06679.12 CDI76987.1 - 5.2 7.5 8.2 7.6 6.9 8.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) FKBP_N PF01346.18 CDI76987.1 - 6.2 7.9 15.2 5.1 8.1 13.2 1.9 1 1 1 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase FNIP_N PF14636.6 CDI76988.1 - 4.2 8.3 7.8 8.1 7.4 7.8 1.4 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus DUF2722 PF10846.8 CDI76991.1 - 0.00066 18.7 2.4 0.00079 18.5 2.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI76991.1 - 0.0026 17.8 5.5 0.0029 17.7 5.5 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI76991.1 - 0.0038 16.9 9.4 0.0057 16.3 9.4 1.2 1 0 0 1 1 1 1 Spt20 family Activator_LAG-3 PF11498.8 CDI76991.1 - 0.057 12.4 13.3 0.077 12.0 13.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SARAF PF06682.12 CDI76991.1 - 0.062 12.9 0.5 0.092 12.4 0.5 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Med3 PF11593.8 CDI76991.1 - 0.14 11.3 7.0 0.22 10.7 7.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FTZ PF03867.14 CDI76991.1 - 1.5 8.3 3.6 0.79 9.2 1.2 1.6 2 0 0 2 2 2 0 Fushi tarazu (FTZ), N-terminal region Med15 PF09606.10 CDI76991.1 - 2.9 6.5 29.4 5.5 5.5 29.4 1.4 1 1 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PIP5K PF01504.18 CDI76992.1 - 0.0005 19.4 7.7 0.0005 19.4 7.7 1.3 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase HEAT PF02985.22 CDI76992.1 - 0.0043 17.2 0.3 0.017 15.3 0.3 2.1 1 0 0 1 1 1 1 HEAT repeat Ribosomal_60s PF00428.19 CDI76992.1 - 0.052 14.1 1.2 0.052 14.1 1.2 3.3 4 0 0 4 4 4 0 60s Acidic ribosomal protein ASC PF00858.24 CDI76992.1 - 0.065 12.2 6.1 0.095 11.6 6.1 1.2 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel MAM33 PF02330.16 CDI76992.1 - 0.25 11.3 22.0 0.53 10.2 6.3 2.5 3 0 0 3 3 3 0 Mitochondrial glycoprotein DUF2371 PF10177.9 CDI76992.1 - 0.42 10.8 4.5 0.18 11.9 2.0 1.7 2 0 0 2 2 1 0 Uncharacterised conserved protein (DUF2371) DUF3347 PF11827.8 CDI76992.1 - 0.45 10.7 15.1 2.1 8.5 2.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3347) EIIBC-GUT_N PF03612.14 CDI76992.1 - 1.1 8.9 22.0 1.2 8.8 6.0 3.0 3 0 0 3 3 3 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 CDI76992.1 - 1.5 7.5 26.5 0.15 10.8 19.3 2.0 2 0 0 2 2 2 0 Presenilin DUF4637 PF15470.6 CDI76992.1 - 1.9 8.2 10.7 6 6.6 2.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Orf78 PF06024.12 CDI76992.1 - 1.9 8.8 15.9 3.4 8.0 1.5 3.1 3 0 0 3 3 3 0 Orf78 (ac78) RNA_pol_Rbc25 PF08292.12 CDI76992.1 - 1.9 8.7 19.5 0.12 12.6 2.1 2.8 3 0 0 3 3 3 0 RNA polymerase III subunit Rpc25 PBP1_TM PF14812.6 CDI76992.1 - 2.1 8.8 8.4 8.6 6.8 2.2 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PRP1_N PF06424.12 CDI76992.1 - 3.1 8.2 20.2 1 9.7 1.1 2.9 3 0 0 3 3 3 0 PRP1 splicing factor, N-terminal DUF5523 PF17661.1 CDI76992.1 - 3.6 7.2 23.3 1.1 8.9 4.0 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5523) SRP9-21 PF05486.12 CDI76992.1 - 3.7 8.0 17.6 0.75 10.2 3.4 2.6 1 1 1 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) SpoIIP PF07454.11 CDI76992.1 - 5.9 6.3 23.2 0.26 10.7 2.4 2.4 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) Tuberin PF03542.16 CDI76992.1 - 6.6 5.7 10.6 5.1 6.1 9.0 1.6 1 1 1 2 2 2 0 Tuberin Rad54_N PF08658.10 CDI76992.1 - 7.9 6.6 16.8 1.5 8.9 0.4 3.0 3 0 0 3 3 3 0 Rad54 N terminal Consortin_C PF15281.6 CDI77004.1 - 0.013 15.5 1.7 0.013 15.5 1.7 1.8 1 1 1 2 2 2 0 Consortin C-terminus DUF2370 PF10176.9 CDI77004.1 - 0.069 12.8 2.5 0.12 12.0 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Presenilin PF01080.17 CDI77004.1 - 0.12 11.1 11.7 0.16 10.7 11.7 1.3 1 0 0 1 1 1 0 Presenilin Serinc PF03348.15 CDI77004.1 - 0.15 10.9 2.3 0.19 10.6 2.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Activator_LAG-3 PF11498.8 CDI77004.1 - 0.43 9.5 69.4 0.64 8.9 69.4 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Zip PF02535.22 CDI77004.1 - 0.51 9.5 3.7 0.71 9.0 3.7 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter LMBR1 PF04791.16 CDI77004.1 - 0.54 9.1 4.1 0.64 8.9 4.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein PigN PF04987.14 CDI77004.1 - 1.4 7.7 8.2 0.77 8.5 6.6 1.3 1 1 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Peptidase_M56 PF05569.11 CDI77004.1 - 1.5 8.0 7.4 2.4 7.3 7.4 1.3 1 0 0 1 1 1 0 BlaR1 peptidase M56 CSG2 PF16965.5 CDI77004.1 - 3.8 6.4 6.0 5.3 5.9 6.0 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator Kei1 PF08552.11 CDI77004.1 - 4.8 7.0 12.0 0.29 11.0 3.9 2.4 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 MDM10 PF12519.8 CDI77004.1 - 6.2 5.6 13.2 8.3 5.1 13.2 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SPT6_acidic PF14632.6 CDI77005.1 - 6.9e-08 33.0 8.4 6.9e-08 33.0 8.4 11.6 9 3 2 11 11 11 1 Acidic N-terminal SPT6 RskA PF10099.9 CDI77005.1 - 0.0068 16.7 11.8 0.0068 16.7 11.8 16.4 8 4 6 15 15 15 5 Anti-sigma-K factor rskA IMUP PF15761.5 CDI77005.1 - 0.0081 16.8 5.0 0.0081 16.8 5.0 14.8 9 3 4 13 13 13 2 Immortalisation up-regulated protein Presenilin PF01080.17 CDI77006.1 - 0.016 14.0 43.1 0.017 13.9 43.1 1.0 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI77006.1 - 0.75 9.8 31.1 0.9 9.5 31.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Gti1_Pac2 PF09729.9 CDI77006.1 - 0.8 9.8 31.6 1.1 9.3 31.6 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF3295 PF11702.8 CDI77006.1 - 1.5 8.1 33.7 1.8 7.9 33.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DUF2052 PF09747.9 CDI77006.1 - 1.9 8.6 39.2 2.3 8.3 39.2 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF3807 PF12720.7 CDI77006.1 - 1.9 8.7 48.0 2.7 8.2 48.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) SLC12 PF03522.15 CDI77006.1 - 2.9 6.8 41.1 3.2 6.7 41.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DAG_kinase_N PF14513.6 CDI77006.1 - 3.3 7.9 33.9 5.1 7.3 33.9 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus RR_TM4-6 PF06459.12 CDI77006.1 - 4 7.2 42.8 4.7 6.9 42.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Apt1 PF10351.9 CDI77006.1 - 4.2 6.1 27.7 4.4 6.0 27.7 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4045 PF13254.6 CDI77006.1 - 4.7 6.8 33.6 5.4 6.6 33.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF572 PF04502.13 CDI77006.1 - 6 6.4 33.9 8.4 5.9 33.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Vfa1 PF08432.10 CDI77006.1 - 6.3 7.1 39.9 7.9 6.8 39.9 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF2828 PF11443.8 CDI77006.1 - 6.8 4.6 35.0 9.2 4.2 35.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Endostatin PF06482.11 CDI77006.1 - 6.9 6.0 35.4 8.3 5.8 35.4 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Raftlin PF15250.6 CDI77006.1 - 7.9 5.1 31.2 8.6 5.0 31.2 1.0 1 0 0 1 1 1 0 Raftlin Hid1 PF12722.7 CDI77006.1 - 8.9 4.3 36.8 10 4.1 36.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SMC_N PF02463.19 CDI77007.1 - 5.2e-18 65.3 1.4 1.2e-17 64.1 0.1 1.9 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDI77007.1 - 5.1e-08 33.1 0.5 8e-08 32.4 0.0 1.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDI77007.1 - 4.7e-07 29.5 0.0 1.2e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CDI77007.1 - 9.2e-05 22.3 3.0 0.00037 20.3 3.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_16 PF13191.6 CDI77007.1 - 0.0001 22.7 2.5 0.0001 22.7 2.5 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 CDI77007.1 - 0.00017 22.2 5.1 0.00017 22.2 5.1 3.0 1 1 1 2 2 1 1 AAA domain ABC_tran PF00005.27 CDI77007.1 - 0.00017 22.1 1.0 0.00066 20.2 0.9 2.0 1 1 0 1 1 1 1 ABC transporter Med3 PF11593.8 CDI77007.1 - 0.0011 18.2 20.9 0.0011 18.2 20.9 2.6 2 1 0 2 2 1 1 Mediator complex subunit 3 fungal NCKAP5 PF15246.6 CDI77007.1 - 0.0048 16.6 8.9 0.0075 15.9 8.9 1.4 1 0 0 1 1 1 1 Nck-associated protein 5, Peripheral clock protein AAA_27 PF13514.6 CDI77007.1 - 0.046 13.3 0.0 0.046 13.3 0.0 2.2 1 1 1 2 2 2 0 AAA domain Apt1 PF10351.9 CDI77007.1 - 0.069 12.0 14.7 0.084 11.7 14.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain AAA_22 PF13401.6 CDI77007.1 - 0.087 13.1 0.2 0.16 12.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CDI77007.1 - 0.095 12.7 0.1 0.6 10.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RskA PF10099.9 CDI77007.1 - 0.13 12.6 42.4 0.045 14.0 15.0 2.3 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF4512 PF14975.6 CDI77007.1 - 0.56 11.0 0.0 0.56 11.0 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4512) MAT1 PF06391.13 CDI77007.1 - 0.56 10.0 14.7 0.38 10.5 11.2 2.0 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Macoilin PF09726.9 CDI77007.1 - 3 6.3 19.9 5.3 5.5 19.9 1.4 1 0 0 1 1 1 0 Macoilin family DUF1117 PF06547.12 CDI77007.1 - 5.8 7.5 9.7 15 6.2 9.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1117) ATP-synt_D PF01813.17 CDI77010.1 - 0.046 13.5 4.4 0.19 11.5 0.4 2.2 2 0 0 2 2 2 0 ATP synthase subunit D LMF1 PF06762.14 CDI77011.1 - 6.6e-14 51.9 0.0 8.9e-14 51.4 0.0 1.1 1 0 0 1 1 1 1 Lipase maturation factor TMPIT PF07851.13 CDI77015.1 - 0.12 11.6 29.3 0.14 11.4 29.3 1.0 1 0 0 1 1 1 0 TMPIT-like protein CDC45 PF02724.14 CDI77015.1 - 0.43 8.8 15.7 0.48 8.7 15.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Sec62 PF03839.16 CDI77015.1 - 1.5 8.3 21.0 1.7 8.1 21.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 LAP1C PF05609.12 CDI77015.1 - 2.3 7.2 25.9 2.5 7.1 25.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CemA PF03040.14 CDI77015.1 - 2.4 8.0 19.9 3.2 7.6 19.9 1.3 1 0 0 1 1 1 0 CemA family DUF3492 PF11997.8 CDI77015.1 - 4 7.1 12.2 4.2 7.0 12.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) HCO3_cotransp PF00955.21 CDI77015.1 - 9.4 4.9 11.2 9.6 4.9 11.2 1.0 1 0 0 1 1 1 0 HCO3- transporter family PRP38_assoc PF12871.7 CDI77017.1 - 0.041 14.5 185.1 0.91 10.2 57.3 5.1 1 1 3 4 4 4 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Spt20 PF12090.8 CDI77019.1 - 0.0034 17.0 22.6 0.0034 17.0 22.6 1.0 1 0 0 1 1 1 1 Spt20 family Presenilin PF01080.17 CDI77019.1 - 0.16 10.7 9.8 0.14 10.9 9.8 1.0 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 CDI77019.1 - 0.17 10.7 11.4 0.16 10.7 11.4 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CPSF100_C PF13299.6 CDI77019.1 - 0.19 11.9 7.5 0.18 11.9 7.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DDHD PF02862.17 CDI77019.1 - 0.22 11.7 6.6 0.19 11.8 6.6 1.1 1 0 0 1 1 1 0 DDHD domain DUF4834 PF16118.5 CDI77019.1 - 0.24 12.4 12.6 0.25 12.3 12.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SpoIIP PF07454.11 CDI77019.1 - 0.25 10.8 12.6 0.25 10.8 12.6 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) eIF-3_zeta PF05091.12 CDI77019.1 - 0.35 9.8 11.8 0.3 10.0 11.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3408 PF11888.8 CDI77019.1 - 0.36 11.0 14.0 0.38 10.9 14.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF4820 PF16091.5 CDI77019.1 - 0.49 9.7 9.3 0.49 9.7 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) eIF_4EBP PF05456.11 CDI77019.1 - 0.52 10.3 8.6 0.6 10.1 8.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) DUF1980 PF09323.10 CDI77019.1 - 0.53 10.2 5.4 0.48 10.3 5.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) V_ATPase_I PF01496.19 CDI77019.1 - 0.63 7.9 9.3 0.59 8.0 9.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Androgen_recep PF02166.16 CDI77019.1 - 0.66 8.8 23.1 0.72 8.6 23.1 1.1 1 0 0 1 1 1 0 Androgen receptor EOS1 PF12326.8 CDI77019.1 - 0.68 9.8 2.8 0.6 10.0 2.8 1.1 1 0 0 1 1 1 0 N-glycosylation protein Band_3_cyto PF07565.13 CDI77019.1 - 0.74 9.6 7.0 0.65 9.8 7.0 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF913 PF06025.12 CDI77019.1 - 0.83 8.6 6.0 0.79 8.6 6.0 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) BORG_CEP PF14957.6 CDI77019.1 - 0.85 10.8 8.2 0.88 10.7 8.2 1.1 1 0 0 1 1 1 0 Cdc42 effector TFIIA PF03153.13 CDI77019.1 - 0.86 9.5 21.8 0.78 9.7 21.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4175 PF13779.6 CDI77019.1 - 0.94 7.3 20.1 0.83 7.5 20.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TFB6 PF17110.5 CDI77019.1 - 1.2 8.8 6.8 1.2 8.9 6.8 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RR_TM4-6 PF06459.12 CDI77019.1 - 1.5 8.6 14.2 1.5 8.5 14.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF775 PF05603.12 CDI77019.1 - 2.3 7.7 10.8 2.6 7.5 10.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Neur_chan_memb PF02932.16 CDI77019.1 - 4 7.4 6.7 3.5 7.6 6.7 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EIIBC-GUT_N PF03612.14 CDI77019.1 - 7.3 6.3 13.1 7.9 6.2 13.1 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus SID-1_RNA_chan PF13965.6 CDI77019.1 - 7.9 4.8 5.0 7.3 4.9 5.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 CDI77019.1 - 8 5.3 5.0 7.7 5.3 5.0 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator CobT PF06213.12 CDI77019.1 - 9 5.6 22.5 9.5 5.5 22.5 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Zip PF02535.22 CDI77019.1 - 9.1 5.4 6.8 8.2 5.5 6.8 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter EMC3_TMCO1 PF01956.16 CDI77019.1 - 9.3 5.9 10.0 9.3 6.0 10.0 1.0 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Spt20 PF12090.8 CDI77024.1 - 0.00095 18.8 6.8 0.00095 18.8 6.8 7.0 4 2 2 6 6 6 1 Spt20 family BUD22 PF09073.10 CDI77034.1 - 0.00069 19.1 1.6 0.00069 19.1 1.6 4.9 1 1 3 4 4 4 1 BUD22 DUF3539 PF12058.8 CDI77042.1 - 0.25 11.5 1.8 0.49 10.6 1.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3539) TFIIA PF03153.13 CDI77042.1 - 1.2 9.0 24.2 1.2 9.0 5.3 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RNA_polI_A34 PF08208.11 CDI77042.1 - 3.8 7.5 9.4 0.17 11.9 2.4 2.0 2 1 1 3 3 3 0 DNA-directed RNA polymerase I subunit RPA34.5 Activator_LAG-3 PF11498.8 CDI77050.1 - 0.00087 18.4 38.4 0.0012 17.9 38.4 1.1 1 0 0 1 1 1 1 Transcriptional activator LAG-3 Band_3_cyto PF07565.13 CDI77050.1 - 0.0014 18.5 3.2 0.0019 18.0 3.2 1.2 1 0 0 1 1 1 1 Band 3 cytoplasmic domain SR-25 PF10500.9 CDI77050.1 - 0.0015 18.2 3.0 0.0021 17.7 3.0 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CCDC106 PF15794.5 CDI77050.1 - 0.082 12.6 7.1 0.13 12.0 7.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Ndc1_Nup PF09531.10 CDI77050.1 - 0.095 11.4 6.2 0.11 11.2 6.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Suf PF05843.14 CDI77050.1 - 0.1 12.6 8.7 0.14 12.1 8.7 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DDHD PF02862.17 CDI77050.1 - 0.3 11.2 3.6 0.4 10.8 3.6 1.3 1 0 0 1 1 1 0 DDHD domain MID_MedPIWI PF18296.1 CDI77050.1 - 0.31 10.8 10.3 0.45 10.3 10.3 1.2 1 0 0 1 1 1 0 MID domain of medPIWI MAT1 PF06391.13 CDI77050.1 - 0.49 10.2 9.7 0.87 9.4 9.7 1.4 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 NPR3 PF03666.13 CDI77050.1 - 0.93 8.2 5.7 1.2 7.9 5.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC12 PF03522.15 CDI77050.1 - 1.4 7.9 7.1 1.7 7.6 7.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI77050.1 - 1.8 8.5 5.8 2.3 8.2 5.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 CDI77050.1 - 3.1 5.8 10.0 3.7 5.6 10.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Rtf2 PF04641.12 CDI77050.1 - 4.3 6.6 10.0 6.6 6.0 10.0 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger MRI PF15325.6 CDI77050.1 - 5.7 8.1 7.1 18 6.5 7.1 1.9 1 0 0 1 1 1 0 Modulator of retrovirus infection XRN_M PF17846.1 CDI77050.1 - 7.2 5.4 5.7 9.1 5.1 5.7 1.1 1 0 0 1 1 1 0 Xrn1 helical domain SPX PF03105.19 CDI77052.1 - 0.48 10.3 11.2 0.53 10.2 11.2 1.1 1 0 0 1 1 1 0 SPX domain SR-25 PF10500.9 CDI77052.1 - 0.88 9.1 31.5 0.091 12.4 27.3 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Apt1 PF10351.9 CDI77052.1 - 1.3 7.8 9.0 1.3 7.8 9.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 CDI77052.1 - 2.1 7.8 4.5 2.3 7.7 4.5 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Miga PF10265.9 CDI77052.1 - 3.5 6.5 12.1 3.8 6.4 12.1 1.1 1 0 0 1 1 1 0 Mitoguardin ERM PF00769.19 CDI77052.1 - 5.9 6.6 8.8 7.9 6.2 8.8 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family MAP65_ASE1 PF03999.12 CDI77052.1 - 6.2 5.4 8.6 6.9 5.2 8.6 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) AF-4 PF05110.13 CDI77052.1 - 7.5 4.5 24.3 8.9 4.2 24.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF2722 PF10846.8 CDI77064.1 - 0.0016 17.5 5.2 0.0016 17.5 5.2 2.7 2 2 0 3 3 3 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI77064.1 - 0.14 12.1 32.9 0.34 10.9 11.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Cellulose_synt PF03552.14 CDI77064.1 - 0.15 10.6 1.1 0.22 10.0 1.1 1.2 1 0 0 1 1 1 0 Cellulose synthase DUF3504 PF12012.8 CDI77064.1 - 6.1 6.7 13.4 0.22 11.4 7.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3504) SUIM_assoc PF16619.5 CDI77066.1 - 7.2e-06 26.0 1.7 7.2e-06 26.0 1.7 5.0 3 2 0 3 3 2 1 Unstructured region C-term to UIM in Ataxin3 RLL PF10036.9 CDI77066.1 - 0.0025 17.7 19.1 0.0048 16.8 7.5 2.5 2 0 0 2 2 2 2 RNA transcription, translation and transport factor protein RRM PF10378.9 CDI77066.1 - 0.011 15.4 0.8 0.011 15.4 0.8 4.7 4 1 0 4 4 3 0 Putative RRM domain TCP PF03634.13 CDI77066.1 - 0.016 15.8 20.0 0.14 12.7 5.2 2.3 2 0 0 2 2 2 0 TCP family transcription factor DUF4471 PF14740.6 CDI77066.1 - 0.093 11.9 7.2 0.023 13.9 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) FHIPEP PF00771.20 CDI77066.1 - 0.14 10.6 11.7 0.061 11.8 3.6 2.1 2 0 0 2 2 2 0 FHIPEP family Presenilin PF01080.17 CDI77066.1 - 0.84 8.3 21.6 0.024 13.4 3.6 2.2 2 1 0 2 2 2 0 Presenilin RNase_H2_suC PF08615.11 CDI77066.1 - 0.91 9.7 8.6 0.42 10.8 0.5 2.6 2 1 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DUF4175 PF13779.6 CDI77066.1 - 0.98 7.2 48.0 0.011 13.7 17.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) DUF3807 PF12720.7 CDI77066.1 - 1 9.6 26.2 0.4 10.9 10.7 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) eIF-3_zeta PF05091.12 CDI77066.1 - 1.8 7.5 22.1 1.1 8.1 11.8 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) LPMO_10 PF03067.15 CDI77066.1 - 1.9 9.1 17.2 0.96 10.1 7.0 2.2 2 0 0 2 2 2 0 Lytic polysaccharide mono-oxygenase, cellulose-degrading ESM4 PF15952.5 CDI77066.1 - 2.4 8.5 36.9 1.1 9.7 16.0 2.4 2 0 0 2 2 2 0 Enhancer of split M4 family Connexin PF00029.19 CDI77066.1 - 3.2 7.4 15.5 0.46 10.2 6.5 2.4 3 0 0 3 3 3 0 Connexin PAT1 PF09770.9 CDI77066.1 - 4.6 5.4 41.6 1 7.5 10.8 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 PRC2_HTH_1 PF18118.1 CDI77066.1 - 4.9 8.0 17.5 3.3 8.5 7.3 3.0 3 0 0 3 3 3 0 Polycomb repressive complex 2 tri-helical domain Glt_symporter PF03616.14 CDI77066.1 - 5 5.7 7.3 0.37 9.4 1.0 2.1 2 0 0 2 2 2 0 Sodium/glutamate symporter SNF5 PF04855.12 CDI77066.1 - 5.6 6.7 16.2 6.7 6.4 0.3 2.3 2 0 0 2 2 2 0 SNF5 / SMARCB1 / INI1 GAGA_bind PF06217.12 CDI77066.1 - 8 6.6 17.7 2 8.6 2.3 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family V_ATPase_I PF01496.19 CDI77066.1 - 8.6 4.1 20.9 4.8 5.0 3.6 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family TFIIA PF03153.13 CDI77066.1 - 9 6.2 69.4 1.6 8.6 36.8 2.2 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit YABBY PF04690.13 CDI77066.1 - 10 6.7 18.4 13 6.3 6.9 2.9 3 0 0 3 3 3 0 YABBY protein RskA PF10099.9 CDI77077.1 - 9.9e-06 26.0 3.6 0.0021 18.4 0.4 5.5 2 2 2 4 4 4 3 Anti-sigma-K factor rskA DUF2681 PF10883.8 CDI77077.1 - 0.0017 18.7 1.8 0.0017 18.7 1.8 5.4 4 1 1 5 5 5 1 Protein of unknown function (DUF2681) DUF755 PF05501.11 CDI77077.1 - 0.013 15.7 21.2 0.013 15.7 21.2 7.5 7 1 1 8 8 8 0 Domain of unknown function (DUF755) SUIM_assoc PF16619.5 CDI77077.1 - 0.014 15.5 5.8 0.014 15.5 5.8 7.0 4 2 1 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 MASE2 PF05230.11 CDI77077.1 - 2.5 8.2 6.3 19 5.4 0.2 3.8 3 0 0 3 3 3 0 MASE2 domain BAF1_ABF1 PF04684.13 CDI77077.1 - 7.8 5.4 32.1 4 6.4 10.1 3.3 3 0 0 3 3 3 0 BAF1 / ABF1 chromatin reorganising factor Trp_oprn_chp PF09534.10 CDI77092.1 - 0.0013 18.5 27.4 0.0013 18.5 27.4 1.9 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) CcmF_C PF16327.5 CDI77092.1 - 0.42 9.9 4.9 0.57 9.4 4.9 1.2 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal TctA PF01970.16 CDI77092.1 - 0.95 8.1 8.5 1.5 7.5 8.5 1.2 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family eIF-3_zeta PF05091.12 CDI77092.1 - 5.8 5.8 38.8 1.2 8.1 23.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SARAF PF06682.12 CDI77092.1 - 7.3 6.1 29.8 0.19 11.3 12.1 2.1 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis cobW PF02492.19 CDI77109.1 - 5e-07 29.5 10.3 7.9e-05 22.3 3.2 4.0 2 2 2 4 4 4 2 CobW/HypB/UreG, nucleotide-binding domain Transposase_20 PF02371.16 CDI77109.1 - 0.0017 18.6 0.9 0.0052 17.1 0.9 1.8 1 0 0 1 1 1 1 Transposase IS116/IS110/IS902 family DUF2722 PF10846.8 CDI77109.1 - 0.0044 16.0 6.1 0.0044 16.0 6.1 5.9 4 2 1 5 5 5 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI77109.1 - 0.0087 16.4 10.4 0.0087 16.4 10.4 5.8 3 1 0 4 4 4 2 Anti-sigma-K factor rskA Ribosomal_60s PF00428.19 CDI77112.1 - 0.21 12.2 29.0 0.39 11.3 12.0 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF2052 PF09747.9 CDI77112.1 - 0.25 11.5 32.9 0.35 11.0 1.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Utp14 PF04615.13 CDI77112.1 - 0.33 9.5 33.2 0.47 9.0 33.2 1.1 1 0 0 1 1 1 0 Utp14 protein RR_TM4-6 PF06459.12 CDI77112.1 - 0.79 9.5 31.4 2.4 7.9 0.8 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 CDI77112.1 - 0.84 8.5 28.0 0.14 11.1 19.9 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spore_coat_CotO PF14153.6 CDI77112.1 - 0.87 9.5 42.4 2.4 8.0 26.7 2.3 2 0 0 2 2 2 0 Spore coat protein CotO Nop53 PF07767.11 CDI77112.1 - 1.5 8.1 34.8 0.28 10.5 20.3 2.2 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) ATP-synt_D PF01813.17 CDI77115.1 - 2.8e-31 108.9 1.0 3.4e-31 108.6 1.0 1.2 1 0 0 1 1 1 1 ATP synthase subunit D mIF3 PF14877.6 CDI77115.1 - 0.0075 16.0 0.1 0.0088 15.7 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial translation initiation factor Metallophos PF00149.28 CDI77127.1 - 9.6e-22 78.5 0.1 1.3e-21 78.1 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 CDI77127.1 - 0.027 14.1 0.0 0.041 13.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain RskA PF10099.9 CDI77127.1 - 0.6 10.4 19.7 0.071 13.4 10.3 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI77127.1 - 0.82 9.8 15.4 1.7 8.8 15.4 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 SR-25 PF10500.9 CDI77132.1 - 5.2e-05 23.0 7.0 6.8e-05 22.6 7.0 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein T2SSE PF00437.20 CDI77132.1 - 0.00027 20.1 0.1 0.00034 19.8 0.1 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein Peptidase_S49_N PF08496.10 CDI77132.1 - 0.00029 20.9 4.9 0.00036 20.6 4.9 1.2 1 0 0 1 1 1 1 Peptidase family S49 N-terminal V_ATPase_I PF01496.19 CDI77132.1 - 0.0017 16.4 5.1 0.0017 16.4 5.1 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family TFIIA PF03153.13 CDI77132.1 - 0.002 18.2 27.0 0.0021 18.1 27.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2052 PF09747.9 CDI77132.1 - 0.0021 18.3 7.2 0.0023 18.1 7.2 1.1 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) DUF3984 PF13136.6 CDI77132.1 - 0.0043 16.5 8.3 0.0045 16.4 8.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3984) CCSAP PF15748.5 CDI77132.1 - 0.0046 17.2 11.0 0.0053 17.0 11.0 1.1 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated DDHD PF02862.17 CDI77132.1 - 0.005 17.0 5.5 0.005 17.0 5.5 1.1 1 0 0 1 1 1 1 DDHD domain SpoIIP PF07454.11 CDI77132.1 - 0.0056 16.2 8.0 0.0064 16.0 8.0 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CDI77132.1 - 0.0068 15.2 9.6 0.0072 15.1 9.6 1.1 1 0 0 1 1 1 1 Presenilin Adeno_IVa2 PF02456.15 CDI77132.1 - 0.008 15.0 0.1 0.0094 14.8 0.1 1.1 1 0 0 1 1 1 1 Adenovirus IVa2 protein Pex14_N PF04695.13 CDI77132.1 - 0.0089 16.7 15.6 0.01 16.5 15.6 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region AAA_16 PF13191.6 CDI77132.1 - 0.011 16.1 1.3 0.011 16.1 1.3 2.0 1 1 1 2 2 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 CDI77132.1 - 0.011 15.6 1.2 0.015 15.2 1.2 1.2 1 0 0 1 1 1 0 RsgA GTPase Nitroreductase PF00881.24 CDI77132.1 - 0.011 15.7 3.0 0.014 15.5 3.0 1.1 1 0 0 1 1 1 0 Nitroreductase family SLC12 PF03522.15 CDI77132.1 - 0.019 14.0 8.3 0.021 13.9 8.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 AAA_29 PF13555.6 CDI77132.1 - 0.025 14.3 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.19 CDI77132.1 - 0.032 13.8 2.4 0.041 13.5 0.0 2.1 2 1 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 CDI77132.1 - 0.037 13.9 0.0 0.082 12.8 0.0 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea CPSF100_C PF13299.6 CDI77132.1 - 0.044 14.0 7.6 0.054 13.7 7.6 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Peroxin-13_N PF04088.13 CDI77132.1 - 0.046 14.0 4.3 0.067 13.5 4.3 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region PAT1 PF09770.9 CDI77132.1 - 0.057 11.7 17.1 0.057 11.7 17.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TAF1D PF15333.6 CDI77132.1 - 0.063 13.0 7.2 0.078 12.7 7.2 1.1 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D Suf PF05843.14 CDI77132.1 - 0.067 13.2 12.9 0.075 13.0 12.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4770 PF15994.5 CDI77132.1 - 0.068 13.4 9.3 0.076 13.2 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Lin-8 PF03353.15 CDI77132.1 - 0.07 12.7 11.8 0.081 12.5 11.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CCDC53 PF10152.9 CDI77132.1 - 0.071 13.5 9.0 0.089 13.2 9.0 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex EPL1 PF10513.9 CDI77132.1 - 0.073 13.5 8.8 0.09 13.2 8.8 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like FAM176 PF14851.6 CDI77132.1 - 0.073 12.7 4.3 0.096 12.3 4.3 1.2 1 0 0 1 1 1 0 FAM176 family MDM10 PF12519.8 CDI77132.1 - 0.077 11.9 5.3 0.078 11.8 5.3 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF4175 PF13779.6 CDI77132.1 - 0.084 10.8 27.2 0.09 10.7 27.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Kei1 PF08552.11 CDI77132.1 - 0.092 12.6 3.6 0.1 12.5 3.6 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 AAA_24 PF13479.6 CDI77132.1 - 0.1 12.3 3.5 0.82 9.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF4228 PF14009.6 CDI77132.1 - 0.11 12.8 3.9 0.13 12.7 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) GET2 PF08690.10 CDI77132.1 - 0.11 12.1 11.3 0.16 11.6 11.3 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Dala_Dala_lig_N PF01820.21 CDI77132.1 - 0.12 12.9 0.4 0.18 12.2 0.4 1.3 1 0 0 1 1 1 0 D-ala D-ala ligase N-terminus OATP PF03137.20 CDI77132.1 - 0.12 10.6 5.4 0.15 10.3 5.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Peptidase_M56 PF05569.11 CDI77132.1 - 0.13 11.5 2.3 0.17 11.1 2.3 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 AAA_23 PF13476.6 CDI77132.1 - 0.13 12.8 16.6 29 5.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain Velvet PF11754.8 CDI77132.1 - 0.13 12.2 13.3 0.14 12.0 13.3 1.1 1 0 0 1 1 1 0 Velvet factor AAA_18 PF13238.6 CDI77132.1 - 0.14 12.7 0.5 12 6.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain Connexin PF00029.19 CDI77132.1 - 0.17 11.6 8.6 0.23 11.2 8.6 1.1 1 0 0 1 1 1 0 Connexin Eapp_C PF10238.9 CDI77132.1 - 0.17 11.9 14.5 0.24 11.5 14.5 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein Neur_chan_memb PF02932.16 CDI77132.1 - 0.18 11.8 7.2 0.19 11.7 7.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GNT-I PF03071.15 CDI77132.1 - 0.19 10.4 5.7 0.23 10.2 5.7 1.1 1 0 0 1 1 1 0 GNT-I family Afi1 PF07792.12 CDI77132.1 - 0.21 12.1 9.6 0.27 11.7 9.6 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PBP1_TM PF14812.6 CDI77132.1 - 0.29 11.5 6.2 0.48 10.8 6.2 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UPF0560 PF10577.9 CDI77132.1 - 0.34 9.4 19.5 0.37 9.2 19.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 POPLD PF08170.12 CDI77132.1 - 0.36 11.2 5.6 0.55 10.6 5.6 1.2 1 0 0 1 1 1 0 POPLD (NUC188) domain Ctr PF04145.15 CDI77132.1 - 0.37 11.4 5.6 0.43 11.2 5.6 1.2 1 0 0 1 1 1 0 Ctr copper transporter family PepSY_TM PF03929.16 CDI77132.1 - 0.37 10.4 4.4 0.41 10.3 4.4 1.1 1 0 0 1 1 1 0 PepSY-associated TM region CobT PF06213.12 CDI77132.1 - 0.52 9.7 20.1 0.72 9.2 20.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RR_TM4-6 PF06459.12 CDI77132.1 - 0.52 10.1 10.8 0.66 9.8 10.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MMR1 PF08505.10 CDI77132.1 - 0.54 10.5 16.5 0.58 10.4 16.5 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Coilin_N PF15862.5 CDI77132.1 - 0.55 10.0 13.3 0.83 9.4 13.3 1.4 1 0 0 1 1 1 0 Coilin N-terminus PIP5K PF01504.18 CDI77132.1 - 0.58 9.3 9.0 0.76 9.0 9.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase MMU163 PF17119.5 CDI77132.1 - 0.62 9.2 6.2 0.83 8.8 6.2 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis eIF-3_zeta PF05091.12 CDI77132.1 - 0.63 9.0 16.9 0.77 8.7 16.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFB6 PF17110.5 CDI77132.1 - 0.63 9.8 9.5 0.91 9.2 9.5 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Folate_carrier PF01770.18 CDI77132.1 - 0.64 8.7 7.4 0.89 8.2 7.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier Glt_symporter PF03616.14 CDI77132.1 - 0.64 8.6 2.9 0.82 8.3 2.9 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter CLN3 PF02487.17 CDI77132.1 - 0.65 9.0 8.3 0.83 8.6 8.3 1.1 1 0 0 1 1 1 0 CLN3 protein Ndc1_Nup PF09531.10 CDI77132.1 - 0.68 8.6 8.2 0.72 8.5 8.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AAA PF00004.29 CDI77132.1 - 0.91 9.9 0.0 0.91 9.9 0.0 2.3 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Rrn6 PF10214.9 CDI77132.1 - 0.92 7.9 18.6 0.95 7.9 18.6 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor ALMT PF11744.8 CDI77132.1 - 0.94 8.2 8.2 0.99 8.2 8.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Med15 PF09606.10 CDI77132.1 - 1.1 7.9 30.4 1.2 7.7 30.4 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RNA12 PF10443.9 CDI77132.1 - 1.1 7.9 0.0 1.1 7.9 0.0 2.0 1 1 1 2 2 1 0 RNA12 protein EIIBC-GUT_N PF03612.14 CDI77132.1 - 1.1 9.0 11.1 1.6 8.5 11.1 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus P5-ATPase PF12409.8 CDI77132.1 - 1.2 9.2 9.4 1.8 8.7 9.4 1.2 1 0 0 1 1 1 0 P5-type ATPase cation transporter Membralin PF09746.9 CDI77132.1 - 1.3 8.0 6.4 1.4 7.9 6.4 1.1 1 0 0 1 1 1 0 Tumour-associated protein Scs3p PF10261.9 CDI77132.1 - 1.3 8.4 5.4 1.8 8.0 5.4 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM AAA_33 PF13671.6 CDI77132.1 - 1.4 9.1 10.2 3.8 7.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF2828 PF11443.8 CDI77132.1 - 1.4 6.9 12.6 1.7 6.6 12.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) EMC3_TMCO1 PF01956.16 CDI77132.1 - 1.4 8.6 7.9 1.6 8.5 7.9 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Peptidase_U57 PF05582.12 CDI77132.1 - 1.6 8.0 9.5 2.2 7.5 9.5 1.2 1 0 0 1 1 1 0 YabG peptidase U57 EOS1 PF12326.8 CDI77132.1 - 1.6 8.7 7.9 2.2 8.2 7.9 1.2 1 0 0 1 1 1 0 N-glycosylation protein TMEM51 PF15345.6 CDI77132.1 - 1.8 8.4 14.4 2.6 7.8 14.4 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 CSG2 PF16965.5 CDI77132.1 - 1.9 7.3 7.7 2.6 6.9 7.7 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4407 PF14362.6 CDI77132.1 - 1.9 7.7 13.0 2.5 7.4 13.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Plasmodium_Vir PF05795.11 CDI77132.1 - 2.1 7.7 6.3 2.4 7.5 6.3 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein ORC_WH_C PF18137.1 CDI77132.1 - 2.4 8.2 12.0 3.7 7.6 12.0 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Paramyxo_ncap PF00973.19 CDI77132.1 - 2.5 6.9 7.6 2.7 6.8 7.6 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PRC2_HTH_1 PF18118.1 CDI77132.1 - 2.5 8.9 10.6 3.9 8.3 10.6 1.3 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Cellulose_synt PF03552.14 CDI77132.1 - 2.6 6.4 3.5 2.7 6.4 3.5 1.0 1 0 0 1 1 1 0 Cellulose synthase TCP PF03634.13 CDI77132.1 - 2.6 8.6 17.1 3.6 8.1 17.1 1.2 1 0 0 1 1 1 0 TCP family transcription factor Tim54 PF11711.8 CDI77132.1 - 2.6 6.7 10.8 3.4 6.3 10.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PAF-AH_p_II PF03403.13 CDI77132.1 - 2.7 6.4 10.1 3.3 6.1 10.1 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II HGTP_anticodon2 PF12745.7 CDI77132.1 - 2.9 7.3 14.7 3.9 6.9 14.7 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Renin_r PF07850.14 CDI77132.1 - 3.2 8.4 4.7 5.8 7.6 4.7 1.4 1 0 0 1 1 1 0 Renin receptor-like protein AIF_C PF14721.6 CDI77132.1 - 3.5 8.0 10.5 5.1 7.5 10.5 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RBP_receptor PF14752.6 CDI77132.1 - 3.5 6.1 11.6 4.5 5.7 11.6 1.0 1 0 0 1 1 1 0 Retinol binding protein receptor GREB1 PF15782.5 CDI77132.1 - 3.6 4.6 15.1 4 4.4 15.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PigN PF04987.14 CDI77132.1 - 3.6 6.3 6.9 4.5 6.0 6.9 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Folliculin PF11704.8 CDI77132.1 - 3.7 7.4 10.4 4.9 7.0 10.4 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Orf78 PF06024.12 CDI77132.1 - 3.7 7.9 9.8 7.8 6.9 9.5 1.6 1 1 0 1 1 1 0 Orf78 (ac78) HCO3_cotransp PF00955.21 CDI77132.1 - 4.3 6.0 5.8 5.3 5.7 5.8 1.0 1 0 0 1 1 1 0 HCO3- transporter family MCU PF04678.13 CDI77132.1 - 4.4 7.4 10.5 6.7 6.8 10.5 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Ureide_permease PF07168.11 CDI77132.1 - 4.5 5.9 5.0 5.9 5.5 5.0 1.2 1 0 0 1 1 1 0 Ureide permease UPF0239 PF06783.11 CDI77132.1 - 4.6 7.5 9.3 7.5 6.8 9.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) AAA_28 PF13521.6 CDI77132.1 - 4.7 7.4 0.0 4.7 7.4 0.0 2.2 2 0 0 2 2 1 0 AAA domain DUF3464 PF11947.8 CDI77132.1 - 4.8 6.9 14.1 7.1 6.4 14.1 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 SID-1_RNA_chan PF13965.6 CDI77132.1 - 5.5 5.3 7.2 6.6 5.0 7.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 YABBY PF04690.13 CDI77132.1 - 5.6 7.5 11.6 7.5 7.1 11.6 1.2 1 0 0 1 1 1 0 YABBY protein MDM31_MDM32 PF08118.11 CDI77132.1 - 5.8 5.5 11.0 7.4 5.1 11.0 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Het-C PF07217.11 CDI77132.1 - 5.9 5.3 11.4 7.5 5.0 11.4 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF2126 PF09899.9 CDI77132.1 - 6.1 4.8 10.0 7.2 4.5 10.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Saw1 PF11561.8 CDI77132.1 - 6.1 6.3 10.9 8.2 5.9 10.9 1.1 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Serinc PF03348.15 CDI77132.1 - 7.2 5.4 10.2 9.3 5.0 10.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) G0-G1_switch_2 PF15103.6 CDI77132.1 - 8.5 6.9 10.8 18 5.8 10.8 1.6 1 0 0 1 1 1 0 G0/G1 switch protein 2 Cas1_AcylT PF07779.12 CDI77132.1 - 9 5.1 8.2 13 4.5 8.2 1.2 1 0 0 1 1 1 0 10 TM Acyl Transferase domain found in Cas1p DXP_synthase_N PF13292.6 CDI77133.1 - 2.9e-37 128.4 0.2 2.9e-37 128.4 0.2 3.4 4 0 0 4 4 4 1 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 CDI77133.1 - 8.2e-28 97.3 0.1 8.2e-28 97.3 0.1 2.2 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain DUF2722 PF10846.8 CDI77133.1 - 0.0007 18.7 2.8 0.0007 18.7 2.8 6.0 6 1 1 7 7 7 2 Protein of unknown function (DUF2722) Androgen_recep PF02166.16 CDI77133.1 - 0.0016 17.4 8.4 0.0016 17.4 8.4 11.0 6 4 5 12 12 12 1 Androgen receptor TFIIA PF03153.13 CDI77133.1 - 0.0033 17.5 21.8 0.0033 17.5 21.8 4.5 3 1 1 4 4 4 1 Transcription factor IIA, alpha/beta subunit Fumble PF03630.14 CDI77134.1 - 3.4e-05 23.2 3.2 3.4e-05 23.2 3.2 5.5 1 1 3 4 4 4 2 Fumble PAP1 PF08601.10 CDI77134.1 - 0.00077 19.3 50.0 0.62 9.7 0.0 3.7 3 1 0 3 3 3 2 Transcription factor PAP1 DUF2722 PF10846.8 CDI77134.1 - 0.0027 16.7 29.7 0.0053 15.8 10.4 6.4 5 1 1 6 6 6 3 Protein of unknown function (DUF2722) RskA PF10099.9 CDI77134.1 - 0.0029 17.9 16.5 0.0029 17.9 16.5 7.0 2 2 3 5 5 5 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI77134.1 - 0.0049 16.9 18.1 0.0049 16.9 18.1 4.7 3 1 1 4 4 4 2 Transcription factor IIA, alpha/beta subunit DUF898 PF05987.13 CDI77134.1 - 0.0073 15.4 2.3 0.0073 15.4 2.3 2.0 3 0 0 3 3 3 1 Bacterial protein of unknown function (DUF898) DUF1757 PF08560.10 CDI77134.1 - 0.01 15.9 1.0 0.031 14.3 1.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1757) DUF2480 PF10652.9 CDI77134.1 - 2.3 8.1 6.8 0.11 12.4 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2480) RAP1 PF07218.11 CDI77134.1 - 5.4 5.2 30.5 0.05 11.9 7.5 2.2 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) BUD22 PF09073.10 CDI77134.1 - 9.1 5.5 53.1 0.15 11.4 8.2 4.2 3 1 0 4 4 4 0 BUD22 RskA PF10099.9 CDI77154.1 - 8.5e-06 26.2 6.6 8.5e-06 26.2 6.6 4.6 2 2 2 4 4 4 2 Anti-sigma-K factor rskA Methyltransf_34 PF11312.8 CDI77154.1 - 0.0044 16.3 3.3 0.016 14.4 0.1 2.4 2 0 0 2 2 2 1 Putative SAM-dependent methyltransferase Rpp20 PF12328.8 CDI77154.1 - 0.018 15.0 1.0 0.018 15.0 1.0 2.3 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Vma12 PF11712.8 CDI77154.1 - 0.065 13.3 2.7 0.2 11.7 0.2 2.4 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Reticulon PF02453.17 CDI77154.1 - 0.081 12.9 0.1 0.26 11.3 0.1 1.8 1 0 0 1 1 1 0 Reticulon EIIBC-GUT_N PF03612.14 CDI77154.1 - 0.15 11.7 2.3 2.2 8.0 0.8 2.4 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus MecA PF05389.12 CDI77154.1 - 0.83 9.2 5.9 5.5 6.6 0.1 2.3 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF3276 PF11680.8 CDI77154.1 - 1.3 9.1 4.0 0.61 10.2 1.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3276) SARAF PF06682.12 CDI77156.1 - 0.0056 16.4 1.7 0.007 16.1 1.7 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis BAF1_ABF1 PF04684.13 CDI77156.1 - 0.0061 15.7 3.6 0.0072 15.4 3.6 1.1 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor DUF1345 PF07077.11 CDI77156.1 - 0.0084 15.8 1.4 0.87 9.3 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1345) SR-25 PF10500.9 CDI77156.1 - 0.085 12.4 13.6 0.12 12.0 13.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AgrB PF04647.15 CDI77156.1 - 0.12 11.7 0.1 0.18 11.1 0.1 1.2 1 0 0 1 1 1 0 Accessory gene regulator B Myc_N PF01056.18 CDI77156.1 - 0.37 10.7 5.7 0.44 10.4 5.7 1.1 1 0 0 1 1 1 0 Myc amino-terminal region PsbW PF07123.12 CDI77156.1 - 0.67 10.0 3.4 1 9.4 2.2 1.8 2 0 0 2 2 2 0 Photosystem II reaction centre W protein (PsbW) NrsF PF06532.11 CDI77156.1 - 0.99 9.1 12.2 0.15 11.8 1.4 2.1 2 0 0 2 2 2 0 Negative regulator of sigma F AC_N PF16214.5 CDI77156.1 - 2.8 7.0 9.4 3.7 6.6 9.4 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region Hid1 PF12722.7 CDI77156.1 - 5.2 5.1 6.2 5.2 5.1 6.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Conotoxin PF02950.17 CDI77156.1 - 7.8 7.6 0.0 7.8 7.6 0.0 3.8 2 1 2 4 4 4 0 Conotoxin VAD1-2 PF15310.6 CDI77156.1 - 8.5 6.2 16.3 2.7 7.8 0.9 3.0 2 1 1 3 3 3 0 Vitamin A-deficiency (VAD) rat model signalling SR-25 PF10500.9 CDI77183.1 - 0.015 14.9 2.1 0.015 14.9 2.1 8.0 6 3 1 7 7 7 0 Nuclear RNA-splicing-associated protein AAA_23 PF13476.6 CDI77183.1 - 0.03 14.8 36.2 1.6 9.2 12.0 3.5 3 0 0 3 3 3 0 AAA domain CNDH2_C PF16858.5 CDI77183.1 - 0.14 12.0 29.6 1.3 8.8 9.9 3.4 3 1 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term TRAP_alpha PF03896.16 CDI77183.1 - 1.7 7.8 9.1 0.92 8.7 4.1 2.4 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Adaptin_binding PF10199.9 CDI77183.1 - 2.5 8.7 35.1 2.6 8.7 11.0 4.4 3 1 1 4 4 4 0 Alpha and gamma adaptin binding protein p34 SID-1_RNA_chan PF13965.6 CDI77183.1 - 3 6.2 12.7 0.061 11.7 1.1 2.7 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 rRNA_processing PF08524.11 CDI77183.1 - 4.2 7.4 47.1 0.95 9.5 15.6 4.3 4 0 0 4 4 4 0 rRNA processing DUF3504 PF12012.8 CDI77185.1 - 0.0034 17.3 0.9 0.0034 17.3 0.9 3.4 4 0 0 4 4 4 1 Domain of unknown function (DUF3504) Coilin_N PF15862.5 CDI77185.1 - 0.013 15.3 2.0 0.013 15.3 2.0 5.5 6 0 0 6 6 6 0 Coilin N-terminus DUF1180 PF06679.12 CDI77185.1 - 0.02 15.3 5.1 0.02 15.3 5.1 5.1 4 1 0 5 5 5 0 Protein of unknown function (DUF1180) DUF755 PF05501.11 CDI77185.1 - 0.026 14.8 10.3 0.026 14.8 10.3 7.6 5 2 2 7 7 4 0 Domain of unknown function (DUF755) TRAP_alpha PF03896.16 CDI77185.1 - 0.21 10.8 9.3 0.48 9.6 0.5 3.8 4 0 0 4 4 4 0 Translocon-associated protein (TRAP), alpha subunit Connexin PF00029.19 CDI77185.1 - 0.26 11.0 17.8 0.28 10.9 1.4 4.1 5 0 0 5 5 5 0 Connexin INSIG PF07281.12 CDI77185.1 - 0.66 9.6 8.4 0.086 12.5 2.4 2.5 3 0 0 3 3 3 0 Insulin-induced protein (INSIG) DUF4148 PF13663.6 CDI77185.1 - 2.2 8.5 34.0 1.1 9.5 2.0 6.2 6 0 0 6 6 6 0 Domain of unknown function (DUF4148) Imm5 PF14423.6 CDI77185.1 - 6.5 6.9 6.9 1.5 9.0 0.7 2.4 2 0 0 2 2 2 0 Immunity protein Imm5 DUF4179 PF13786.6 CDI77185.1 - 7 7.2 15.7 26 5.4 0.1 4.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4179) RskA PF10099.9 CDI77185.1 - 9.1 6.5 64.5 0.042 14.1 1.6 5.4 2 1 2 5 5 4 0 Anti-sigma-K factor rskA Neur_chan_memb PF02932.16 CDI77196.1 - 0.011 15.8 3.1 0.011 15.8 3.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF913 PF06025.12 CDI77196.1 - 0.018 14.0 3.1 0.021 13.8 3.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DDHD PF02862.17 CDI77196.1 - 0.029 14.5 6.1 0.035 14.3 6.1 1.1 1 0 0 1 1 1 0 DDHD domain EOS1 PF12326.8 CDI77196.1 - 0.036 14.0 0.2 0.036 14.0 0.2 1.1 1 0 0 1 1 1 0 N-glycosylation protein DUF2722 PF10846.8 CDI77196.1 - 0.061 12.3 28.6 0.083 11.8 28.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF3408 PF11888.8 CDI77196.1 - 0.069 13.3 9.3 0.12 12.5 9.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) PAT1 PF09770.9 CDI77196.1 - 0.072 11.4 21.2 0.075 11.3 21.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NARP1 PF12569.8 CDI77196.1 - 0.095 11.6 8.1 0.11 11.3 8.1 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TFIIA PF03153.13 CDI77196.1 - 0.096 12.7 50.0 0.12 12.3 50.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF775 PF05603.12 CDI77196.1 - 0.23 11.0 10.2 0.35 10.4 10.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Connexin PF00029.19 CDI77196.1 - 0.28 10.9 5.9 0.34 10.6 5.9 1.1 1 0 0 1 1 1 0 Connexin DUF5427 PF10310.9 CDI77196.1 - 0.32 9.9 15.9 0.35 9.8 15.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) FAM60A PF15396.6 CDI77196.1 - 0.34 10.9 7.6 0.46 10.4 7.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Stig1 PF04885.13 CDI77196.1 - 0.36 11.3 8.7 0.51 10.8 8.7 1.1 1 0 0 1 1 1 0 Stigma-specific protein, Stig1 Peroxin-3 PF04882.12 CDI77196.1 - 0.38 9.7 12.4 0.44 9.5 12.4 1.1 1 0 0 1 1 1 0 Peroxin-3 RR_TM4-6 PF06459.12 CDI77196.1 - 0.4 10.5 12.8 0.51 10.1 12.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SpoIIP PF07454.11 CDI77196.1 - 0.53 9.7 13.0 0.67 9.4 13.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Rxt3 PF08642.10 CDI77196.1 - 0.58 10.9 4.1 0.87 10.4 4.1 1.3 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Endostatin PF06482.11 CDI77196.1 - 0.67 9.4 12.8 0.9 8.9 12.8 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF3464 PF11947.8 CDI77196.1 - 0.81 9.4 11.2 1.4 8.7 11.2 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 UPF0560 PF10577.9 CDI77196.1 - 0.82 8.1 19.1 1 7.8 19.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Tim54 PF11711.8 CDI77196.1 - 0.84 8.4 12.5 1.3 7.8 12.5 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 OATP PF03137.20 CDI77196.1 - 1.4 7.1 5.4 1.7 6.8 5.4 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Presenilin PF01080.17 CDI77196.1 - 1.4 7.6 16.9 1.9 7.2 16.9 1.1 1 0 0 1 1 1 0 Presenilin DUF2126 PF09899.9 CDI77196.1 - 1.5 6.8 7.1 1.8 6.6 7.1 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Ureide_permease PF07168.11 CDI77196.1 - 1.8 7.2 4.7 2.7 6.7 4.7 1.2 1 0 0 1 1 1 0 Ureide permease TERB2 PF15101.6 CDI77196.1 - 1.9 8.5 18.1 2.4 8.1 18.1 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CPSF100_C PF13299.6 CDI77196.1 - 2.3 8.4 11.5 0.29 11.3 7.6 1.6 2 0 0 2 2 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4820 PF16091.5 CDI77196.1 - 2.3 7.5 11.2 3.4 7.0 11.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) CSG2 PF16965.5 CDI77196.1 - 2.5 7.0 4.8 2.8 6.8 4.8 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator EIF4E-T PF10477.9 CDI77196.1 - 2.5 6.8 19.8 3.1 6.5 19.8 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Band_3_cyto PF07565.13 CDI77196.1 - 2.8 7.7 11.0 3.5 7.3 11.0 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FAM176 PF14851.6 CDI77196.1 - 3.7 7.2 6.9 5.2 6.7 6.9 1.2 1 0 0 1 1 1 0 FAM176 family G0-G1_switch_2 PF15103.6 CDI77196.1 - 3.7 8.0 9.0 7.2 7.1 9.0 1.5 1 0 0 1 1 1 0 G0/G1 switch protein 2 GREB1 PF15782.5 CDI77196.1 - 3.8 4.5 12.9 4.4 4.3 12.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 CDI77196.1 - 4.1 6.3 11.5 5.1 6.0 11.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 EIIBC-GUT_N PF03612.14 CDI77196.1 - 4.3 7.1 12.3 5.9 6.6 12.3 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus MMR1 PF08505.10 CDI77196.1 - 4.3 7.6 15.6 5.6 7.2 15.6 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Otopetrin PF03189.13 CDI77196.1 - 4.4 6.0 7.5 5 5.8 7.5 1.0 1 0 0 1 1 1 0 Otopetrin Folate_carrier PF01770.18 CDI77196.1 - 4.5 5.9 6.4 5.6 5.6 6.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier PIP5K PF01504.18 CDI77196.1 - 6 6.0 10.6 7.6 5.7 10.6 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Gti1_Pac2 PF09729.9 CDI77196.1 - 6.7 6.8 10.8 8.9 6.4 10.8 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Zip PF02535.22 CDI77196.1 - 6.8 5.8 7.3 8.7 5.5 7.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter eIF-3_zeta PF05091.12 CDI77196.1 - 7.1 5.5 20.0 9.1 5.1 20.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF1980 PF09323.10 CDI77196.1 - 7.3 6.5 10.1 9.6 6.1 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF4770 PF15994.5 CDI77196.1 - 8 6.7 14.9 12 6.1 14.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) MAJIN PF15077.6 CDI77196.1 - 8.7 6.1 9.2 12 5.6 9.2 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein V_ATPase_I PF01496.19 CDI77196.1 - 9.3 4.0 13.5 11 3.8 13.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PPL5 PF18168.1 CDI77197.1 - 4.4 6.5 15.4 4.3 6.5 15.4 1.0 1 0 0 1 1 1 0 Prim-pol family 5 eIF3_subunit PF08597.10 CDI77197.1 - 5.2 6.9 30.2 6.6 6.6 30.2 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit PSK PF06404.12 CDI77197.1 - 9.1 7.4 14.7 10 7.2 14.7 1.1 1 0 0 1 1 1 0 Phytosulfokine precursor protein (PSK) DUF998 PF06197.13 CDI77206.1 - 0.35 10.4 28.2 0.6 9.7 28.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF998) Utp14 PF04615.13 CDI77206.1 - 8.8 4.8 8.1 10 4.6 8.1 1.0 1 0 0 1 1 1 0 Utp14 protein GT87 PF09594.10 CDI77213.1 - 0.058 13.1 12.2 0.029 14.1 4.3 2.4 2 1 0 2 2 2 0 Glycosyltransferase family 87 Tic110 PF16940.5 CDI77213.1 - 0.7 8.3 14.1 0.89 8.0 14.1 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter RskA PF10099.9 CDI77213.1 - 6.9 6.9 46.3 4.3 7.6 33.0 2.7 1 1 2 3 3 3 0 Anti-sigma-K factor rskA SARAF PF06682.12 CDI77213.1 - 7.1 6.2 54.1 2.7e+02 1.0 54.1 2.1 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis ATG7_N PF16420.5 CDI77222.1 - 0.00095 18.9 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus FAP PF07174.11 CDI77222.1 - 1.2 8.6 29.2 1.7 8.0 29.2 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) ATG7_N PF16420.5 CDI77223.1 - 9.9e-08 32.0 0.4 9.9e-08 32.0 0.4 7.2 2 2 3 6 6 6 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus Sin_N PF04801.13 CDI77223.1 - 0.0012 18.2 25.2 0.0012 18.2 25.2 4.8 3 2 1 4 4 4 1 Sin-like protein conserved region DRTGG PF07085.12 CDI77223.1 - 0.32 10.8 2.0 0.73 9.7 2.0 1.6 1 0 0 1 1 1 0 DRTGG domain rRNA_processing PF08524.11 CDI77224.1 - 0.018 15.1 23.8 0.02 14.9 23.8 1.1 1 0 0 1 1 1 0 rRNA processing FAM199X PF15814.5 CDI77224.1 - 0.09 11.8 27.1 0.11 11.6 27.1 1.0 1 0 0 1 1 1 0 Protein family FAM199X Nop53 PF07767.11 CDI77224.1 - 0.32 10.3 22.0 0.37 10.1 22.0 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF945 PF06097.11 CDI77224.1 - 1.8 7.6 21.7 2.1 7.4 21.7 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) DUF5588 PF17826.1 CDI77224.1 - 2.1 7.1 16.3 2.5 6.9 16.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5588) Suf PF05843.14 CDI77224.1 - 3.5 7.5 30.7 4 7.3 30.7 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) BSP_II PF05432.11 CDI77224.1 - 4.3 6.9 21.0 4.9 6.8 21.0 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Corona_nucleoca PF00937.18 CDI77224.1 - 5 6.1 30.4 5.6 5.9 30.4 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein RAP1 PF07218.11 CDI77224.1 - 7.3 4.7 15.7 7.6 4.7 15.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) NAM-associated PF14303.6 CDI77224.1 - 7.4 7.3 27.2 9.7 6.9 27.2 1.1 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF4175 PF13779.6 CDI77224.1 - 7.9 4.3 27.1 7.7 4.3 27.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SprA-related PF12118.8 CDI77224.1 - 9.6 5.2 41.3 12 4.9 41.3 1.1 1 0 0 1 1 1 0 SprA-related family DUF1906 PF08924.11 CDI77225.1 - 0.11 12.7 2.8 0.19 11.9 2.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1906) FAM104 PF15434.6 CDI77225.1 - 6.2 7.4 18.4 12 6.5 0.2 3.2 3 0 0 3 3 3 0 Family 104 SUZ PF12752.7 CDI77225.1 - 8.9 7.2 14.3 16 6.4 0.6 3.5 3 0 0 3 3 3 0 SUZ domain SR-25 PF10500.9 CDI77238.1 - 4.2 6.9 73.8 0.11 12.1 35.3 2.3 1 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein CobT PF06213.12 CDI77260.1 - 0.00023 20.7 15.5 0.00027 20.4 15.5 1.0 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT MAT1 PF06391.13 CDI77260.1 - 0.026 14.4 15.1 0.027 14.3 15.1 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Peroxin-13_N PF04088.13 CDI77260.1 - 0.089 13.1 4.4 0.1 12.8 4.4 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF3801 PF12687.7 CDI77260.1 - 0.12 12.4 11.5 0.15 12.2 11.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) Hydin_ADK PF17213.3 CDI77260.1 - 0.13 12.5 9.9 0.15 12.3 9.9 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Ribonuc_P_40 PF08584.11 CDI77260.1 - 0.14 11.4 5.9 0.17 11.1 5.9 1.1 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit Sec62 PF03839.16 CDI77260.1 - 0.16 11.5 6.0 0.17 11.3 6.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 SLC12 PF03522.15 CDI77260.1 - 0.23 10.4 10.1 0.25 10.3 10.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 CDI77260.1 - 0.24 10.1 10.5 0.26 10.0 10.5 1.0 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI77260.1 - 0.26 11.2 36.9 0.28 11.1 36.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NEMP PF10225.9 CDI77260.1 - 0.33 10.6 5.0 0.39 10.4 5.0 1.0 1 0 0 1 1 1 0 NEMP family Folliculin PF11704.8 CDI77260.1 - 0.34 10.8 6.9 0.39 10.6 6.9 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Med15 PF09606.10 CDI77260.1 - 0.36 9.5 33.0 0.4 9.3 33.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal FAD-oxidase_C PF02913.19 CDI77260.1 - 0.42 10.2 3.4 0.52 9.9 3.4 1.1 1 0 0 1 1 1 0 FAD linked oxidases, C-terminal domain DDHD PF02862.17 CDI77260.1 - 0.53 10.4 9.4 0.61 10.2 9.4 1.1 1 0 0 1 1 1 0 DDHD domain Asparaginase_2 PF01112.18 CDI77260.1 - 0.55 9.2 5.9 0.65 9.0 5.9 1.1 1 0 0 1 1 1 0 Asparaginase TERB2 PF15101.6 CDI77260.1 - 0.65 10.0 16.0 0.79 9.7 16.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Band_3_cyto PF07565.13 CDI77260.1 - 0.76 9.5 9.7 0.82 9.4 9.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PhoQ_Sensor PF08918.10 CDI77260.1 - 0.84 9.5 4.6 1.1 9.1 4.6 1.1 1 0 0 1 1 1 0 PhoQ Sensor CLN3 PF02487.17 CDI77260.1 - 0.9 8.5 7.1 0.93 8.5 7.1 1.0 1 0 0 1 1 1 0 CLN3 protein Pex26 PF07163.12 CDI77260.1 - 0.99 8.6 14.2 1.2 8.4 14.2 1.1 1 0 0 1 1 1 0 Pex26 protein V_ATPase_I PF01496.19 CDI77260.1 - 1 7.2 11.4 1.1 7.1 11.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4175 PF13779.6 CDI77260.1 - 1.1 7.1 31.6 1.2 7.0 31.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ALMT PF11744.8 CDI77260.1 - 1.2 7.9 9.9 1.3 7.7 9.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Connexin PF00029.19 CDI77260.1 - 1.2 8.8 5.3 1.2 8.8 5.3 1.1 1 0 0 1 1 1 0 Connexin eIF-3_zeta PF05091.12 CDI77260.1 - 1.3 8.0 14.4 1.3 7.9 14.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_S49_N PF08496.10 CDI77260.1 - 1.4 9.0 11.9 1.6 8.8 11.9 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal OmpH PF03938.14 CDI77260.1 - 1.5 9.2 34.3 2 8.8 34.3 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) FAM60A PF15396.6 CDI77260.1 - 1.9 8.4 7.2 2.2 8.3 7.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF4446 PF14584.6 CDI77260.1 - 2.4 8.1 6.8 3 7.8 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Glyco_transf_41 PF13844.6 CDI77260.1 - 2.5 6.4 6.9 2.7 6.3 6.9 1.0 1 0 0 1 1 1 0 Glycosyl transferase family 41 Serinc PF03348.15 CDI77260.1 - 3 6.7 4.7 3.2 6.6 4.7 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Het-C PF07217.11 CDI77260.1 - 3.3 6.1 8.7 3.5 6.0 8.7 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C CSG2 PF16965.5 CDI77260.1 - 3.5 6.5 6.0 3.6 6.4 6.0 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator UPF0565 PF10561.9 CDI77260.1 - 3.6 6.7 9.2 4.1 6.5 9.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 HemX PF04375.14 CDI77260.1 - 4.1 6.6 32.6 4.6 6.4 32.6 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Neur_chan_memb PF02932.16 CDI77260.1 - 4.2 7.3 8.7 4.8 7.2 8.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SpoIIP PF07454.11 CDI77260.1 - 4.7 6.6 12.3 5.5 6.4 12.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) XRN1_D2_D3 PF18334.1 CDI77260.1 - 5.1 7.4 6.9 8.6 6.7 6.4 1.6 1 1 1 2 2 2 0 Exoribonuclease Xrn1 D2/D3 domain FAM222A PF15258.6 CDI77260.1 - 6.1 5.8 30.5 6.4 5.8 30.5 1.0 1 0 0 1 1 1 0 Protein family of FAM222A PBP_sp32 PF07222.12 CDI77260.1 - 6.7 6.1 15.1 7.4 5.9 15.1 1.0 1 0 0 1 1 1 0 Proacrosin binding protein sp32 MCU PF04678.13 CDI77260.1 - 7.7 6.6 11.0 9.7 6.3 11.0 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter AAA_23 PF13476.6 CDI77260.1 - 8.9 6.8 23.8 10 6.6 23.8 1.1 1 0 0 1 1 1 0 AAA domain DUF4667 PF15700.5 CDI77267.1 - 4.3 7.4 17.8 0.064 13.3 3.2 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4667) SHMT PF00464.19 CDI77276.1 - 6.9e-167 555.1 0.0 1.1e-90 304.1 0.0 2.1 1 1 1 2 2 2 2 Serine hydroxymethyltransferase ITAM PF02189.15 CDI77276.1 - 0.17 12.4 0.0 45 4.8 0.0 2.7 2 0 0 2 2 2 0 Immunoreceptor tyrosine-based activation motif DUF4094 PF13334.6 CDI77281.1 - 0.32 11.4 4.7 0.37 11.2 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) DUF4834 PF16118.5 CDI77281.1 - 0.46 11.5 6.2 0.59 11.1 6.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DivIC PF04977.15 CDI77281.1 - 1.7 8.5 14.3 2.2 8.1 14.3 1.3 1 0 0 1 1 1 0 Septum formation initiator Presenilin PF01080.17 CDI77281.1 - 2.4 6.8 5.7 2.7 6.7 5.7 1.0 1 0 0 1 1 1 0 Presenilin DUF3464 PF11947.8 CDI77281.1 - 3 7.6 6.1 3.6 7.3 6.1 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Spt20 PF12090.8 CDI77281.1 - 3.8 7.0 31.2 4.8 6.7 31.2 1.1 1 0 0 1 1 1 0 Spt20 family Med15 PF09606.10 CDI77281.1 - 4.8 5.7 22.8 5.3 5.6 22.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2232 PF09991.9 CDI77281.1 - 4.9 6.2 5.7 5.9 6.0 5.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) TFIIA PF03153.13 CDI77281.1 - 5.4 6.9 24.7 6.3 6.7 24.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FTZ PF03867.14 CDI77281.1 - 7.1 6.1 11.0 7.9 5.9 11.0 1.1 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region YfhO PF09586.10 CDI77301.1 - 0.0058 14.9 1.2 0.0068 14.7 1.2 1.0 1 0 0 1 1 1 1 Bacterial membrane protein YfhO Presenilin PF01080.17 CDI77301.1 - 0.012 14.4 0.9 0.014 14.2 0.9 1.1 1 0 0 1 1 1 0 Presenilin Bax1-I PF01027.20 CDI77301.1 - 0.012 15.4 0.6 0.015 15.1 0.6 1.1 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 Peptidase_U4 PF03419.13 CDI77301.1 - 0.029 13.7 0.5 0.04 13.2 0.1 1.4 1 1 1 2 2 2 0 Sporulation factor SpoIIGA DUF4781 PF16013.5 CDI77301.1 - 0.04 12.7 6.7 0.062 12.1 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) Neur_chan_memb PF02932.16 CDI77301.1 - 0.067 13.2 1.2 0.081 13.0 1.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2663 PF10864.8 CDI77301.1 - 0.11 12.9 0.3 0.2 12.1 0.3 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2663) FAM176 PF14851.6 CDI77301.1 - 0.13 11.9 2.1 0.2 11.3 2.1 1.3 1 0 0 1 1 1 0 FAM176 family Exonuc_VII_L PF02601.15 CDI77301.1 - 0.24 10.9 11.4 0.32 10.5 11.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4366 PF14283.6 CDI77301.1 - 0.34 10.9 6.8 4.1 7.4 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Cadherin_C_2 PF16492.5 CDI77301.1 - 0.39 11.5 2.4 0.64 10.8 2.4 1.3 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal AAA_23 PF13476.6 CDI77301.1 - 0.55 10.7 9.9 0.59 10.6 9.9 1.1 1 0 0 1 1 1 0 AAA domain Scs3p PF10261.9 CDI77301.1 - 0.76 9.2 2.7 1.5 8.2 2.7 1.4 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM V_ATPase_I PF01496.19 CDI77301.1 - 2.1 6.1 8.4 2.8 5.7 8.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2149 PF09919.9 CDI77301.1 - 2.3 8.5 5.8 3.8 7.8 5.8 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) Ctr PF04145.15 CDI77301.1 - 2.9 8.5 9.8 0.2 12.3 3.3 2.0 2 1 0 2 2 2 0 Ctr copper transporter family CCDC53 PF10152.9 CDI77301.1 - 4.6 7.6 14.6 2.4 8.6 6.7 2.1 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Helicase_C PF00271.31 CDI77308.1 - 5.4e-22 78.2 0.0 1.3e-21 77.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Cluap1 PF10234.9 CDI77309.1 - 2e-09 37.3 6.9 1.6e-08 34.3 6.9 2.4 1 1 0 1 1 1 1 Clusterin-associated protein-1 RIB43A PF05914.12 CDI77309.1 - 0.0031 16.3 0.6 0.0031 16.3 0.6 2.8 2 1 1 3 3 3 1 RIB43A DUF2528 PF10800.8 CDI77309.1 - 0.17 12.5 0.0 0.4 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2528) Peptidase_C15 PF01470.17 CDI77310.1 - 7.8e-14 52.3 0.0 1e-09 38.9 0.0 2.2 2 0 0 2 2 2 2 Pyroglutamyl peptidase RNA_pol PF00940.19 CDI77312.1 - 3.2e-135 451.2 0.0 3.2e-135 451.2 0.0 4.3 2 2 1 3 3 3 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 CDI77312.1 - 9.7e-12 44.9 13.2 3.6e-09 36.5 0.2 10.9 6 3 1 7 7 7 3 DNA-directed RNA polymerase N-terminal YgbB PF02542.16 CDI77313.1 - 3e-41 141.3 1.2 3.9e-41 140.9 1.2 1.1 1 0 0 1 1 1 1 YgbB family IMUP PF15761.5 CDI77313.1 - 0.078 13.7 5.5 0.24 12.1 5.5 1.9 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 CDI77313.1 - 0.17 11.5 8.2 0.26 10.9 8.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI77322.1 - 0.00047 19.2 24.6 0.021 13.8 2.4 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) DUF726 PF05277.12 CDI77322.1 - 0.023 13.6 0.5 0.028 13.4 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DUF4366 PF14283.6 CDI77322.1 - 0.41 10.7 5.9 0.42 10.6 3.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) DUF2877 PF11392.8 CDI77322.1 - 0.78 10.5 6.2 19 6.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2877) Sec16 PF12932.7 CDI77322.1 - 1.5 9.5 5.5 0.98 10.0 0.4 2.4 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region DUF1980 PF09323.10 CDI77322.1 - 2.1 8.2 8.4 0.23 11.3 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF533 PF04391.12 CDI77322.1 - 2.8 7.5 28.0 0.072 12.7 16.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF533) Itfg2 PF15907.5 CDI77322.1 - 3.5 6.6 8.1 0.099 11.7 1.2 1.7 2 0 0 2 2 2 0 Integrin-alpha FG-GAP repeat-containing protein 2 Tau95_N PF17682.1 CDI77322.1 - 4.4 7.5 8.4 13 6.0 0.4 2.5 2 0 0 2 2 2 0 Tau95 Triple barrel domain Methyltransf_34 PF11312.8 CDI77322.1 - 4.6 6.4 9.6 2.1 7.5 4.3 2.0 1 1 1 2 2 2 0 Putative SAM-dependent methyltransferase Gaa1 PF04114.14 CDI77322.1 - 7.1 5.5 6.1 0.88 8.5 1.7 1.6 1 1 0 2 2 2 0 Gaa1-like, GPI transamidase component Orf78 PF06024.12 CDI77322.1 - 7.2 7.0 9.2 2 8.7 1.4 2.4 2 0 0 2 2 2 0 Orf78 (ac78) C_Hendra PF16821.5 CDI77322.1 - 8.4 6.2 17.1 0.043 13.7 5.0 2.2 2 0 0 2 2 2 0 C protein from hendra and measles viruses AF-4 PF05110.13 CDI77334.1 - 1.3e-05 23.6 37.6 1.3e-05 23.6 37.6 5.1 4 1 1 5 5 5 2 AF-4 proto-oncoprotein RskA PF10099.9 CDI77334.1 - 0.00012 22.5 0.4 0.00012 22.5 0.4 5.6 3 2 1 4 4 4 2 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI77341.1 - 0.0026 17.4 17.1 0.0026 17.4 17.1 4.4 3 1 0 3 3 3 2 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI77341.1 - 0.45 11.2 21.6 1.1 9.9 5.0 4.7 4 0 0 4 4 4 0 Immortalisation up-regulated protein SR-25 PF10500.9 CDI77346.1 - 4.2e-07 29.8 10.9 5.3e-07 29.5 10.9 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein TCP PF03634.13 CDI77346.1 - 0.0012 19.5 7.6 0.0012 19.4 7.6 1.1 1 0 0 1 1 1 1 TCP family transcription factor Velvet PF11754.8 CDI77346.1 - 0.0029 17.6 10.5 0.0033 17.4 10.5 1.1 1 0 0 1 1 1 1 Velvet factor TFIIA PF03153.13 CDI77346.1 - 0.012 15.7 20.9 0.012 15.6 20.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Coilin_N PF15862.5 CDI77346.1 - 0.012 15.4 8.2 0.013 15.3 8.2 1.1 1 0 0 1 1 1 0 Coilin N-terminus ASD2 PF08687.11 CDI77346.1 - 0.013 15.1 6.6 0.014 14.9 6.6 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Pex14_N PF04695.13 CDI77346.1 - 0.016 15.9 15.3 0.019 15.7 15.3 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CCSAP PF15748.5 CDI77346.1 - 0.016 15.4 11.5 0.02 15.1 11.5 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated V_ATPase_I PF01496.19 CDI77346.1 - 0.023 12.7 4.1 0.026 12.5 4.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MID_MedPIWI PF18296.1 CDI77346.1 - 0.027 14.2 12.0 0.033 14.0 12.0 1.1 1 0 0 1 1 1 0 MID domain of medPIWI SMYLE_N PF18615.1 CDI77346.1 - 0.031 13.9 4.8 0.032 13.8 4.8 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain CCDC106 PF15794.5 CDI77346.1 - 0.034 13.8 9.4 0.046 13.4 9.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CSG2 PF16965.5 CDI77346.1 - 0.056 12.4 4.4 0.064 12.2 4.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Neur_chan_memb PF02932.16 CDI77346.1 - 0.061 13.4 7.7 0.073 13.1 7.7 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GREB1 PF15782.5 CDI77346.1 - 0.082 10.0 9.7 0.083 10.0 9.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Band_3_cyto PF07565.13 CDI77346.1 - 0.17 11.6 6.7 0.2 11.4 6.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Bul1_N PF04425.12 CDI77346.1 - 0.34 9.6 12.5 0.42 9.3 12.5 1.0 1 0 0 1 1 1 0 Bul1 N terminus FAM60A PF15396.6 CDI77346.1 - 0.36 10.8 5.7 0.42 10.6 5.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Ndc1_Nup PF09531.10 CDI77346.1 - 0.45 9.1 9.5 0.45 9.1 9.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Suf PF05843.14 CDI77346.1 - 0.5 10.3 11.6 0.54 10.2 11.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Spt20 PF12090.8 CDI77346.1 - 0.63 9.6 28.3 0.93 9.1 28.3 1.3 1 0 0 1 1 1 0 Spt20 family Serinc PF03348.15 CDI77346.1 - 0.66 8.8 2.5 0.66 8.8 2.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) CLN3 PF02487.17 CDI77346.1 - 0.74 8.8 3.4 0.85 8.6 3.4 1.2 1 0 0 1 1 1 0 CLN3 protein THRAP3_BCLAF1 PF15440.6 CDI77346.1 - 0.97 8.4 20.4 1.2 8.1 20.4 1.0 1 0 0 1 1 1 0 THRAP3/BCLAF1 family MRI PF15325.6 CDI77346.1 - 4.5 8.4 9.4 8.4 7.5 9.4 1.4 1 0 0 1 1 1 0 Modulator of retrovirus infection Hid1 PF12722.7 CDI77346.1 - 4.6 5.3 11.4 5.4 5.0 11.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CobT PF06213.12 CDI77346.1 - 5.7 6.2 14.9 6.9 6.0 14.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RICTOR_N PF14664.6 CDI77346.1 - 9.4 5.1 8.6 44 2.9 8.6 1.8 1 1 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term Presenilin PF01080.17 CDI77346.1 - 9.9 4.8 16.7 12 4.5 16.7 1.0 1 0 0 1 1 1 0 Presenilin DUF713 PF05218.14 CDI77396.1 - 2.2e-06 27.5 6.6 9.5 5.9 0.2 7.2 2 2 3 8 8 8 2 Protein of unknown function (DUF713) ATP-synt_D PF01813.17 CDI77396.1 - 2.1e-05 24.4 23.0 0.44 10.3 0.6 6.4 2 2 3 5 5 5 4 ATP synthase subunit D DUF948 PF06103.11 CDI77396.1 - 0.00023 21.4 0.0 33 4.8 0.0 6.1 4 3 2 7 7 7 0 Bacterial protein of unknown function (DUF948) CZB PF13682.6 CDI77396.1 - 0.0006 20.2 8.5 35 4.9 0.4 8.9 5 4 0 5 5 5 0 Chemoreceptor zinc-binding domain YabA PF06156.13 CDI77396.1 - 0.0027 18.3 22.6 1 10.0 1.3 6.6 3 3 3 6 6 6 3 Initiation control protein YabA TraW_N PF12477.8 CDI77396.1 - 0.3 11.1 0.4 7.6 6.6 0.1 3.9 3 0 0 3 3 3 0 Sex factor F TraW protein N terminal Arg_decarb_HB PF17810.1 CDI77396.1 - 1.2 9.4 32.1 6.8 7.0 0.6 9.7 5 4 3 8 8 8 0 Arginine decarboxylase helical bundle domain TFIIA PF03153.13 CDI77398.1 - 0.001 19.2 40.4 0.0013 18.8 40.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Mucin PF01456.17 CDI77398.1 - 0.012 15.6 10.3 0.012 15.6 10.3 2.2 2 1 0 2 2 2 0 Mucin-like glycoprotein Exonuc_VII_L PF02601.15 CDI77398.1 - 0.039 13.5 13.4 0.046 13.3 13.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit RR_TM4-6 PF06459.12 CDI77398.1 - 0.045 13.6 17.1 0.064 13.1 17.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SID-1_RNA_chan PF13965.6 CDI77398.1 - 0.071 11.5 0.4 0.088 11.2 0.4 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PAT1 PF09770.9 CDI77398.1 - 0.078 11.2 27.1 0.092 11.0 27.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Raftlin PF15250.6 CDI77398.1 - 0.23 10.2 19.1 0.3 9.8 19.1 1.1 1 0 0 1 1 1 0 Raftlin Hid1 PF12722.7 CDI77398.1 - 0.28 9.3 19.6 0.35 9.0 19.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CDI77398.1 - 0.91 8.2 26.7 1.3 7.7 26.7 1.2 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI77398.1 - 6.1 6.8 16.7 11 5.9 16.7 1.4 1 0 0 1 1 1 0 Protein Family FAM60A IQ PF00612.27 CDI77410.1 - 0.00094 18.8 0.2 0.0045 16.7 0.0 2.3 2 0 0 2 2 2 1 IQ calmodulin-binding motif AMPK1_CBM PF16561.5 CDI77410.1 - 0.046 13.9 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase Activator_LAG-3 PF11498.8 CDI77411.1 - 4.7 6.1 45.0 0.39 9.6 19.4 2.4 2 0 0 2 2 2 0 Transcriptional activator LAG-3 RskA PF10099.9 CDI77421.1 - 0.4 11.0 13.5 0.53 10.6 13.5 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA TALPID3 PF15324.6 CDI77421.1 - 6.7 4.2 18.0 7.2 4.1 18.0 1.0 1 0 0 1 1 1 0 Hedgehog signalling target Activator_LAG-3 PF11498.8 CDI77421.1 - 6.9 5.5 31.3 7.3 5.4 31.3 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 RNA_pol_Rpc4 PF05132.14 CDI77423.1 - 4.9e-14 53.0 7.0 4.9e-14 53.0 7.0 6.4 5 2 1 6 6 6 1 RNA polymerase III RPC4 AP3D1 PF06375.11 CDI77423.1 - 0.00072 19.8 5.6 0.00072 19.8 5.6 6.0 5 1 1 6 6 6 1 AP-3 complex subunit delta-1 DUF755 PF05501.11 CDI77423.1 - 0.0026 18.0 13.7 0.0026 18.0 13.7 7.5 6 2 0 6 6 6 1 Domain of unknown function (DUF755) Rubella_E2 PF05749.11 CDI77423.1 - 0.039 13.4 0.3 0.072 12.5 0.3 1.4 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 Macoilin PF09726.9 CDI77424.1 - 0.0017 17.0 41.2 0.0017 17.0 41.2 1.6 2 0 0 2 2 1 1 Macoilin family Nha1_C PF08619.10 CDI77424.1 - 0.0059 15.9 31.3 0.048 12.9 16.5 2.1 2 0 0 2 2 2 2 Alkali metal cation/H+ antiporter Nha1 C terminus Neur_chan_memb PF02932.16 CDI77424.1 - 0.032 14.3 25.1 0.2 11.7 19.4 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Membralin PF09746.9 CDI77424.1 - 0.079 12.0 21.4 0.19 10.7 14.2 2.2 2 0 0 2 2 2 0 Tumour-associated protein Hid1 PF12722.7 CDI77424.1 - 0.39 8.8 34.8 0.79 7.8 4.7 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Asp-B-Hydro_N PF05279.11 CDI77424.1 - 0.46 10.5 15.7 0.77 9.8 15.7 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SID-1_RNA_chan PF13965.6 CDI77424.1 - 0.47 8.8 11.5 0.72 8.2 7.7 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Gti1_Pac2 PF09729.9 CDI77424.1 - 0.96 9.5 30.1 3.1 7.8 17.9 2.6 2 0 0 2 2 2 0 Gti1/Pac2 family SLC12 PF03522.15 CDI77424.1 - 2 7.3 38.4 0.2 10.6 26.0 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Zip PF02535.22 CDI77424.1 - 2.2 7.4 21.2 0.67 9.1 11.5 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter DUF2828 PF11443.8 CDI77424.1 - 3.3 5.7 23.0 5.7 4.9 23.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Pex14_N PF04695.13 CDI77424.1 - 3.7 8.2 77.5 8.9 6.9 45.5 3.7 3 2 0 3 3 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HCO3_cotransp PF00955.21 CDI77424.1 - 4.1 6.1 15.4 0.29 9.9 7.8 2.0 2 0 0 2 2 2 0 HCO3- transporter family Suf PF05843.14 CDI77424.1 - 4.6 7.2 45.6 0.33 10.9 33.9 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 CDI77424.1 - 5.3 5.7 45.2 0.85 8.3 29.4 2.2 2 0 0 2 2 2 0 Presenilin RskA PF10099.9 CDI77424.1 - 9 6.5 54.6 0.6 10.4 31.1 4.1 2 1 0 3 3 3 0 Anti-sigma-K factor rskA Hemagglutinin PF00509.18 CDI77432.1 - 0.034 12.6 1.1 0.048 12.1 1.1 1.2 1 0 0 1 1 1 0 Haemagglutinin Noelin-1 PF12308.8 CDI77432.1 - 0.052 13.5 1.1 0.052 13.5 1.1 1.9 2 0 0 2 2 2 0 Neurogenesis glycoprotein JIP_LZII PF16471.5 CDI77432.1 - 0.095 12.9 11.8 0.21 11.8 11.8 1.6 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II DUF4446 PF14584.6 CDI77432.1 - 0.15 12.0 0.3 0.15 12.0 0.3 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) V_ATPase_I PF01496.19 CDI77432.1 - 0.37 8.6 4.0 0.41 8.5 4.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TolA_bind_tri PF16331.5 CDI77432.1 - 2.2 8.4 9.5 0.94 9.6 3.9 2.8 2 1 1 3 3 3 0 TolA binding protein trimerisation CCDC53 PF10152.9 CDI77432.1 - 2.3 8.6 7.4 5.2 7.5 7.4 1.7 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex TraC_F_IV PF11130.8 CDI77432.1 - 2.3 7.7 4.8 3.7 7.1 4.8 1.4 1 1 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer DUF572 PF04502.13 CDI77432.1 - 2.4 7.7 6.1 2.7 7.5 6.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Seryl_tRNA_N PF02403.22 CDI77432.1 - 4.6 7.5 15.8 0.68 10.2 9.1 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF724 PF05266.14 CDI77432.1 - 4.7 7.0 12.0 2.5 7.9 5.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF3584 PF12128.8 CDI77432.1 - 5.4 4.4 20.6 19 2.6 20.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) YabA PF06156.13 CDI77432.1 - 6.6 7.4 6.1 12 6.6 6.1 1.4 1 0 0 1 1 1 0 Initiation control protein YabA RskA PF10099.9 CDI77439.1 - 0.002 18.4 13.5 0.002 18.4 13.5 6.5 1 1 4 5 5 5 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI77439.1 - 0.011 15.3 14.0 0.011 15.3 14.0 4.2 4 1 0 5 5 5 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI77439.1 - 6.8 6.6 88.9 1.1e+02 2.5 44.4 3.1 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit CLN3 PF02487.17 CDI77441.1 - 0.00048 19.3 3.7 0.00048 19.3 3.7 2.6 2 1 0 2 2 1 1 CLN3 protein RskA PF10099.9 CDI77441.1 - 0.00058 20.2 15.4 0.00058 20.2 15.4 4.0 1 1 2 3 3 2 1 Anti-sigma-K factor rskA YL1 PF05764.13 CDI77441.1 - 0.0095 16.1 4.9 0.0095 16.1 4.9 2.3 2 0 0 2 2 2 1 YL1 nuclear protein DUF4207 PF13904.6 CDI77441.1 - 0.014 15.1 31.8 0.14 11.9 9.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) Connexin PF00029.19 CDI77441.1 - 0.015 15.1 9.6 0.023 14.4 3.2 2.3 2 0 0 2 2 2 0 Connexin DUF4448 PF14610.6 CDI77441.1 - 0.029 14.1 2.3 0.92 9.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) TMEM154 PF15102.6 CDI77441.1 - 0.03 14.2 0.0 0.03 14.2 0.0 4.6 2 1 0 2 2 1 0 TMEM154 protein family FmiP_Thoc5 PF09766.9 CDI77441.1 - 0.06 12.6 19.2 0.057 12.7 4.5 2.2 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 PH_4 PF15404.6 CDI77441.1 - 0.2 11.5 12.9 0.53 10.1 1.9 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain rRNA_processing PF08524.11 CDI77441.1 - 0.22 11.5 30.4 1.4 8.9 5.4 2.4 2 0 0 2 2 2 0 rRNA processing Hamartin PF04388.12 CDI77441.1 - 0.32 9.6 31.3 0.42 9.2 31.3 1.1 1 0 0 1 1 1 0 Hamartin protein DUF2207 PF09972.9 CDI77441.1 - 0.48 9.1 2.3 8.7 5.0 0.0 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) PBP1_TM PF14812.6 CDI77441.1 - 0.9 9.9 9.4 0.06 13.7 2.1 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal eIF-3_zeta PF05091.12 CDI77441.1 - 1.1 8.1 22.3 0.94 8.4 9.5 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spem1 PF15670.5 CDI77441.1 - 1.4 8.5 18.7 3.1 7.3 6.5 2.1 2 0 0 2 2 2 0 Spermatid maturation protein 1 DUF1980 PF09323.10 CDI77441.1 - 2.9 7.8 15.3 1.4 8.8 2.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF4770 PF15994.5 CDI77441.1 - 3 8.0 18.3 4.5 7.5 8.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) EMC3_TMCO1 PF01956.16 CDI77441.1 - 3.4 7.4 17.4 0.088 12.5 7.0 2.1 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like GNAT_acetyltr_2 PF13718.6 CDI77441.1 - 3.6 6.9 12.1 1.8 7.9 5.1 2.4 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Rsc14 PF08586.10 CDI77441.1 - 9.6 7.1 13.2 4.3 8.2 3.1 2.6 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit Pinin_SDK_memA PF04696.13 CDI77445.1 - 0.0016 18.5 22.6 0.0016 18.5 22.6 7.4 8 1 0 8 8 8 2 pinin/SDK/memA/ protein conserved region Zip PF02535.22 CDI77445.1 - 3.2 6.9 33.0 0.055 12.7 6.8 3.1 3 0 0 3 3 3 0 ZIP Zinc transporter PIG-U PF06728.13 CDI77456.1 - 0.3 10.1 0.7 1.7 7.6 0.7 2.3 1 0 0 1 1 1 0 GPI transamidase subunit PIG-U DUF2231 PF09990.9 CDI77456.1 - 1.3 9.5 6.1 6.4 7.3 6.1 2.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2231) Sporozoite_P67 PF05642.11 CDI77457.1 - 0.00011 20.5 2.2 0.00011 20.5 2.2 12.4 11 2 0 12 12 12 4 Sporozoite P67 surface antigen SPRY PF00622.28 CDI77457.1 - 0.035 14.2 0.0 0.035 14.2 0.0 5.2 6 1 0 6 6 6 0 SPRY domain RskA PF10099.9 CDI77457.1 - 3.3 8.0 0.0 0.055 13.8 6.6 34.9 11 6 12 25 25 25 0 Anti-sigma-K factor rskA K_channel_TID PF07941.11 CDI77500.1 - 0.0043 17.5 8.7 0.0043 17.5 8.7 9.0 5 3 1 6 6 6 1 Potassium channel Kv1.4 tandem inactivation domain SR-25 PF10500.9 CDI77508.1 - 0.00011 21.9 17.0 0.00011 21.9 17.0 1.3 2 0 0 2 2 1 1 Nuclear RNA-splicing-associated protein DUF4366 PF14283.6 CDI77508.1 - 0.015 15.3 7.6 0.017 15.2 7.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) DUF2370 PF10176.9 CDI77508.1 - 0.024 14.3 9.5 0.025 14.2 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) LptF_LptG PF03739.14 CDI77508.1 - 0.031 13.1 1.9 0.035 13.0 1.9 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG CCSAP PF15748.5 CDI77508.1 - 0.035 14.3 22.8 0.045 13.9 22.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated HCO3_cotransp PF00955.21 CDI77508.1 - 0.044 12.6 8.7 0.048 12.5 8.7 1.1 1 0 0 1 1 1 0 HCO3- transporter family CSG2 PF16965.5 CDI77508.1 - 0.065 12.2 8.4 0.077 11.9 8.4 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator Sarcoglycan_2 PF05510.13 CDI77508.1 - 0.076 11.8 12.3 0.1 11.4 12.3 1.2 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon ABC2_membrane_3 PF12698.7 CDI77508.1 - 0.22 10.6 5.6 0.28 10.2 5.6 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF2126 PF09899.9 CDI77508.1 - 0.31 9.0 8.9 0.32 9.0 8.9 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Ureide_permease PF07168.11 CDI77508.1 - 0.34 9.6 6.2 0.41 9.3 6.2 1.3 1 0 0 1 1 1 0 Ureide permease DUF4746 PF15928.5 CDI77508.1 - 0.51 9.7 10.5 0.63 9.4 10.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Kei1 PF08552.11 CDI77508.1 - 0.65 9.9 13.1 0.65 9.9 12.5 1.5 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 TMEM174 PF15029.6 CDI77508.1 - 0.7 9.6 10.9 1.1 9.0 10.9 1.3 1 0 0 1 1 1 0 Transmembrane protein 174 DUF935 PF06074.12 CDI77508.1 - 0.76 8.4 19.4 0.84 8.3 19.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF935) Caldesmon PF02029.15 CDI77508.1 - 0.78 8.4 25.1 1 8.0 25.1 1.2 1 0 0 1 1 1 0 Caldesmon Nucleoside_tran PF01733.18 CDI77508.1 - 0.96 8.8 8.7 1.3 8.3 8.7 1.2 1 0 0 1 1 1 0 Nucleoside transporter Peptidase_M56 PF05569.11 CDI77508.1 - 1.7 7.7 7.3 2.2 7.4 7.3 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 DUF3112 PF11309.8 CDI77508.1 - 1.8 8.0 8.3 2.4 7.6 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) LMBR1 PF04791.16 CDI77508.1 - 2.2 7.1 14.6 2.6 6.9 14.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein LAP1C PF05609.12 CDI77508.1 - 2.5 7.1 28.1 2.9 6.9 28.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SLC12 PF03522.15 CDI77508.1 - 2.6 7.0 21.8 3.1 6.7 21.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 CDI77508.1 - 3 6.6 14.4 3.4 6.4 14.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter PP_kinase_N PF13089.6 CDI77508.1 - 4 7.8 18.8 1.8 9.0 13.8 2.2 2 0 0 2 2 2 0 Polyphosphate kinase N-terminal domain TMEM154 PF15102.6 CDI77508.1 - 5 7.0 13.5 11 6.0 13.5 1.7 1 1 0 1 1 1 0 TMEM154 protein family 7TM_transglut PF14402.6 CDI77508.1 - 6.3 6.2 9.5 9 5.7 9.5 1.2 1 0 0 1 1 1 0 7 transmembrane helices usually fused to an inactive transglutaminase Cellulose_synt PF03552.14 CDI77508.1 - 9.5 4.6 7.3 9.2 4.6 7.3 1.1 1 0 0 1 1 1 0 Cellulose synthase RskA PF10099.9 CDI77510.1 - 0.00013 22.3 21.2 0.00013 22.3 21.2 2.9 1 1 1 2 2 2 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI77510.1 - 0.00033 20.3 49.4 0.00074 19.2 17.5 2.6 2 1 0 2 2 2 2 Nuclear RNA-splicing-associated protein DUF4179 PF13786.6 CDI77510.1 - 0.027 14.9 0.6 0.027 14.9 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) Macoilin PF09726.9 CDI77510.1 - 0.55 8.7 39.1 0.71 8.3 39.1 1.2 1 0 0 1 1 1 0 Macoilin family AAA_23 PF13476.6 CDI77510.1 - 4.9 7.6 26.4 1.3 9.5 15.0 2.1 2 0 0 2 2 2 0 AAA domain Herpes_glycop PF01528.16 CDI77510.1 - 5.3 5.8 5.3 9.9 4.9 5.3 1.5 1 0 0 1 1 1 0 Herpesvirus glycoprotein M BAF1_ABF1 PF04684.13 CDI77510.1 - 5.5 5.9 40.1 0.053 12.6 24.6 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Glyco_transf_8 PF01501.20 CDI77510.1 - 6.2 6.3 11.4 0.15 11.6 2.9 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 8 MLANA PF14991.6 CDI77510.1 - 9.6 6.5 10.0 0.17 12.2 1.3 2.2 2 1 0 2 2 2 0 Protein melan-A RskA PF10099.9 CDI77522.1 - 0.012 15.9 6.8 0.012 15.9 6.8 4.5 2 1 0 2 2 2 0 Anti-sigma-K factor rskA Shadoo PF14999.6 CDI77522.1 - 1.5 8.9 13.9 0.11 12.6 5.0 2.2 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective GAGA_bind PF06217.12 CDI77529.1 - 0.37 11.1 12.9 0.46 10.7 12.9 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family MMR1 PF08505.10 CDI77529.1 - 0.64 10.3 11.3 0.99 9.6 11.3 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Presenilin PF01080.17 CDI77529.1 - 0.82 8.4 12.2 0.99 8.1 12.2 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI77529.1 - 1.5 8.6 14.7 1.8 8.3 14.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 CDI77529.1 - 2 8.4 8.1 2.2 8.3 8.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.17 CDI77529.1 - 8.2 6.5 9.2 10 6.2 9.2 1.2 1 0 0 1 1 1 0 DDHD domain DUF2052 PF09747.9 CDI77529.1 - 8.3 6.5 15.9 11 6.1 15.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) EGF_CA PF07645.15 CDI77531.1 - 5.1e-57 189.8 79.9 1.3e-11 44.5 7.6 6.1 6 0 0 6 6 6 6 Calcium-binding EGF domain EGF_3 PF12947.7 CDI77531.1 - 3.1e-43 145.6 85.2 4e-09 36.5 10.5 6.3 6 0 0 6 6 6 6 EGF domain cEGF PF12662.7 CDI77531.1 - 2.5e-27 94.5 55.5 1.2e-07 31.5 4.1 6.1 6 0 0 6 6 6 5 Complement Clr-like EGF-like EGF PF00008.27 CDI77531.1 - 2.8e-21 75.5 74.6 8.4e-06 26.0 4.3 6.6 6 0 0 6 6 6 5 EGF-like domain hEGF PF12661.7 CDI77531.1 - 5.6e-17 61.7 63.5 2.1e-05 25.0 3.7 6.7 6 0 0 6 6 6 5 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 CDI77531.1 - 4.8e-15 55.3 56.8 0.00063 19.7 5.8 6.3 6 0 0 6 6 6 5 MSP1 EGF domain 1 Plasmod_Pvs28 PF06247.11 CDI77531.1 - 1.3e-14 54.2 66.9 0.0076 16.5 9.0 6.4 6 0 0 6 6 6 6 Pvs28 EGF domain FXa_inhibition PF14670.6 CDI77531.1 - 3.7e-10 39.9 76.8 0.00091 19.5 5.2 6.5 6 0 0 6 6 6 5 Coagulation Factor Xa inhibitory site EGF_2 PF07974.13 CDI77531.1 - 0.0044 17.3 2.7 0.0044 17.3 2.7 6.3 6 0 0 6 6 6 3 EGF-like domain Zip PF02535.22 CDI77541.1 - 0.27 10.4 2.2 0.57 9.3 2.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF572 PF04502.13 CDI77541.1 - 0.75 9.4 10.2 1.1 8.8 10.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) FapA PF03961.13 CDI77541.1 - 0.8 8.2 8.7 1.1 7.8 8.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A CSG2 PF16965.5 CDI77541.1 - 0.85 8.5 2.1 1.3 7.9 2.1 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 CDI77541.1 - 0.86 8.6 4.7 1.3 8.0 4.7 1.2 1 0 0 1 1 1 0 CLN3 protein BORG_CEP PF14957.6 CDI77541.1 - 2.2 9.5 12.2 6.6 7.9 7.2 2.2 2 0 0 2 2 2 0 Cdc42 effector FAM222A PF15258.6 CDI77541.1 - 9.1 5.3 35.1 0.047 12.8 24.4 2.1 2 0 0 2 2 2 0 Protein family of FAM222A Cpn60_TCP1 PF00118.24 CDI77543.1 - 8.5e-132 440.2 4.7 9.8e-132 440.0 4.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Fer4_12 PF13353.6 CDI77543.1 - 0.19 12.0 0.2 0.36 11.1 0.2 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain TB2_DP1_HVA22 PF03134.19 CDI77544.1 - 2.2e-15 56.4 2.6 3.3e-15 55.8 2.6 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Aa_trans PF01490.18 CDI77544.1 - 0.098 11.3 0.6 0.15 10.7 0.6 1.2 1 0 0 1 1 1 0 Transmembrane amino acid transporter protein SURF1 PF02104.15 CDI77545.1 - 2e-25 90.1 0.1 1.8e-15 57.6 0.0 3.0 2 1 0 2 2 2 2 SURF1 family EFTUD2 PF16004.5 CDI77545.1 - 0.0019 18.7 0.3 0.21 12.2 0.0 2.5 2 0 0 2 2 2 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus IPTL-CTERM PF18203.1 CDI77545.1 - 0.19 11.7 1.4 0.48 10.4 1.4 1.7 1 0 0 1 1 1 0 IPTL-CTERM motif Pet20 PF08692.10 CDI77552.1 - 0.067 13.9 0.3 0.067 13.9 0.3 7.8 5 1 3 8 8 8 0 Mitochondrial protein Pet20 DUF3464 PF11947.8 CDI77556.1 - 0.035 13.9 0.7 0.035 13.9 0.7 5.4 3 1 1 4 4 4 0 Photosynthesis affected mutant 68 DUF2294 PF10057.9 CDI77558.1 - 0.13 12.4 2.2 0.087 13.0 0.7 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2294) Phage_HK97_TLTM PF06120.11 CDI77558.1 - 0.24 10.5 6.5 0.63 9.2 0.2 2.0 1 1 1 2 2 2 0 Tail length tape measure protein CwsA PF10814.8 CDI77558.1 - 0.25 11.5 2.6 0.34 11.1 2.6 1.2 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA AP2 PF00847.20 CDI77565.1 - 9.8e-08 32.1 0.0 9.8e-08 32.1 0.0 4.3 3 1 0 3 3 3 1 AP2 domain SR-25 PF10500.9 CDI77566.1 - 3.4e-05 23.6 35.1 3.7e-05 23.4 35.1 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Nop53 PF07767.11 CDI77566.1 - 0.022 14.1 18.8 0.024 14.1 18.8 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) NPR3 PF03666.13 CDI77566.1 - 0.048 12.5 24.6 0.051 12.4 24.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Spore_coat_CotO PF14153.6 CDI77566.1 - 0.29 11.0 21.8 0.35 10.8 21.8 1.1 1 0 0 1 1 1 0 Spore coat protein CotO rRNA_processing PF08524.11 CDI77566.1 - 0.39 10.7 25.1 0.59 10.2 25.1 1.2 1 0 0 1 1 1 0 rRNA processing SelP_N PF04592.14 CDI77566.1 - 0.45 9.9 20.7 0.5 9.7 20.7 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ASD2 PF08687.11 CDI77566.1 - 0.75 9.3 20.5 0.84 9.1 20.5 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 TFIIA PF03153.13 CDI77566.1 - 0.85 9.5 36.3 1 9.3 36.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 CDI77566.1 - 0.88 9.3 20.4 0.94 9.2 20.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4407 PF14362.6 CDI77566.1 - 1.1 8.5 8.8 1.1 8.6 8.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5427 PF10310.9 CDI77566.1 - 1.3 7.9 26.0 1.5 7.7 26.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) NARP1 PF12569.8 CDI77566.1 - 1.6 7.5 16.4 1.8 7.4 16.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SprA-related PF12118.8 CDI77566.1 - 1.6 7.8 30.2 2.1 7.4 30.2 1.1 1 0 0 1 1 1 0 SprA-related family Velvet PF11754.8 CDI77566.1 - 1.7 8.5 25.2 2 8.3 25.2 1.2 1 0 0 1 1 1 0 Velvet factor DUF4175 PF13779.6 CDI77566.1 - 1.7 6.4 25.4 1.8 6.4 25.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF572 PF04502.13 CDI77566.1 - 2 8.0 25.5 2.1 7.9 25.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Rtf2 PF04641.12 CDI77566.1 - 2.6 7.3 18.7 3 7.1 18.7 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger SMYLE_N PF18615.1 CDI77566.1 - 3.8 7.0 20.5 4.1 6.9 20.5 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain eIF-3_zeta PF05091.12 CDI77566.1 - 4 6.3 22.3 4.3 6.2 22.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI77566.1 - 4.4 6.0 29.4 4.9 5.8 29.4 1.1 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 CDI77566.1 - 5.3 4.8 16.8 5.7 4.7 16.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Menin PF05053.13 CDI77566.1 - 5.5 5.2 16.7 6 5.1 16.7 1.0 1 0 0 1 1 1 0 Menin Raftlin PF15250.6 CDI77566.1 - 5.5 5.6 19.1 5.8 5.6 19.1 1.0 1 0 0 1 1 1 0 Raftlin CDC45 PF02724.14 CDI77566.1 - 6.6 4.9 22.8 7.1 4.8 22.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Endostatin PF06482.11 CDI77566.1 - 7 6.0 21.2 8 5.8 21.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin PNISR PF15996.5 CDI77566.1 - 7.2 6.8 24.1 9.6 6.4 24.1 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Neur_chan_memb PF02932.16 CDI77566.1 - 7.2 6.6 18.8 8.1 6.4 18.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 CDI77566.1 - 7.6 5.6 19.3 8.7 5.5 19.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PA26 PF04636.13 CDI77566.1 - 7.7 5.3 17.3 8.9 5.1 17.3 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) FAM199X PF15814.5 CDI77566.1 - 8.2 5.4 25.6 8.8 5.3 25.6 1.0 1 0 0 1 1 1 0 Protein family FAM199X Suf PF05843.14 CDI77566.1 - 9.9 6.0 29.7 12 5.7 29.7 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hep_59 PF07052.11 CDI77567.1 - 1e-20 74.4 3.4 2.6e-20 73.1 3.4 1.7 1 0 0 1 1 1 1 Hepatocellular carcinoma-associated antigen 59 DUF5385 PF17359.2 CDI77567.1 - 1.3 8.5 6.8 3.2 7.2 0.4 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5385) RskA PF10099.9 CDI77573.1 - 8e-05 23.0 0.1 8e-05 23.0 0.1 12.0 2 2 7 9 9 9 2 Anti-sigma-K factor rskA CDP-OH_P_transf PF01066.21 CDI77576.1 - 2.3e-14 53.9 0.1 2.3e-14 53.9 0.1 4.0 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF3467 PF11950.8 CDI77585.1 - 0.27 11.4 0.0 0.27 11.4 0.0 4.0 4 2 0 4 4 4 0 Protein of unknown function (DUF3467) ELMO_CED12 PF04727.13 CDI77596.1 - 3.1e-10 40.4 0.0 5.4e-10 39.7 0.0 1.5 1 1 0 1 1 1 1 ELMO/CED-12 family GPHH PF16905.5 CDI77596.1 - 0.061 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated His_Phos_2 PF00328.22 CDI77597.1 - 8.4e-10 38.5 12.3 0.00036 20.0 0.6 3.6 4 0 0 4 4 4 3 Histidine phosphatase superfamily (branch 2) AZUL PF16558.5 CDI77597.1 - 0.029 14.6 3.7 3.3 8.0 0.6 3.6 1 1 1 2 2 2 0 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A SAP18 PF06487.12 CDI77597.1 - 0.12 12.6 1.0 7.3 6.8 0.1 2.7 2 0 0 2 2 2 0 Sin3 associated polypeptide p18 (SAP18) LAG1-DNAbind PF09271.11 CDI77597.1 - 0.26 11.9 6.8 0.17 12.5 1.6 2.8 2 0 0 2 2 2 0 LAG1, DNA binding RCR PF12273.8 CDI77597.1 - 0.89 10.2 7.7 11 6.7 0.7 3.1 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red MAGI_u5 PF16666.5 CDI77611.1 - 0.00091 19.4 5.4 0.001 19.2 5.4 1.1 1 0 0 1 1 1 1 Unstructured region on MAGI Asparaginase_2 PF01112.18 CDI77611.1 - 0.0056 15.7 2.9 0.0068 15.5 2.9 1.0 1 0 0 1 1 1 1 Asparaginase TrbI PF03743.14 CDI77611.1 - 0.45 10.3 7.3 0.59 9.9 7.3 1.2 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein DUF3275 PF11679.8 CDI77611.1 - 0.52 10.3 4.4 0.6 10.1 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) DLIC PF05783.11 CDI77611.1 - 0.54 9.0 5.5 0.6 8.9 5.5 1.0 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) CCDC53 PF10152.9 CDI77611.1 - 1.2 9.6 7.1 1.3 9.4 7.1 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Hamartin PF04388.12 CDI77611.1 - 1.4 7.5 5.2 1.6 7.3 5.2 1.0 1 0 0 1 1 1 0 Hamartin protein DUF2057 PF09829.9 CDI77611.1 - 1.7 8.8 12.5 2.1 8.5 12.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) DUF4554 PF15091.6 CDI77611.1 - 2.6 6.8 7.3 3.2 6.6 7.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) SPICE PF15678.5 CDI77611.1 - 3 7.1 9.0 3.3 7.0 9.0 1.0 1 0 0 1 1 1 0 Centriole duplication and mitotic chromosome congression RIFIN PF02009.16 CDI77611.1 - 3.4 7.5 5.9 3.9 7.3 5.9 1.1 1 0 0 1 1 1 0 Rifin FSA_C PF10479.9 CDI77611.1 - 3.5 5.6 8.3 3.5 5.6 8.3 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus FAM199X PF15814.5 CDI77611.1 - 4.1 6.4 6.1 4.8 6.1 6.1 1.0 1 0 0 1 1 1 0 Protein family FAM199X TFIIA PF03153.13 CDI77611.1 - 5.2 7.0 9.2 6.2 6.7 9.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1180 PF06679.12 CDI77611.1 - 5.4 7.4 10.2 5.9 7.3 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) RT_RNaseH_2 PF17919.1 CDI77620.1 - 5e-26 90.7 0.0 1.2e-25 89.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDI77620.1 - 1.7e-18 67.0 0.0 3.3e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CDI77620.1 - 2.4e-16 59.9 0.0 5.8e-16 58.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDI77620.1 - 9.1e-15 54.5 0.3 2.1e-14 53.4 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDI77620.1 - 2.8e-13 50.1 0.0 9.6e-13 48.4 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CDI77620.1 - 2.9e-13 49.5 0.0 5.2e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RVP_2 PF08284.11 CDI77620.1 - 3.1e-09 36.7 0.0 5.7e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CDI77620.1 - 7e-08 33.0 0.0 1.9e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI77620.1 - 3.9e-07 30.5 0.0 9.2e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 CDI77620.1 - 0.00055 19.7 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 CDI77620.1 - 0.019 15.3 0.0 0.046 14.0 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-H2C2 PF09337.10 CDI77620.1 - 0.023 14.9 1.0 0.048 13.9 0.2 2.0 2 0 0 2 2 2 0 H2C2 zinc finger DUF1758 PF05585.12 CDI77620.1 - 0.25 11.1 0.0 0.52 10.1 0.0 1.4 1 0 0 1 1 1 0 Putative peptidase (DUF1758) SRP54_N PF02881.19 CDI77633.1 - 3.7e-13 49.5 0.7 1.1e-12 48.0 0.2 2.1 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain SR-25 PF10500.9 CDI77633.1 - 0.00019 21.1 28.2 0.0075 15.9 12.2 2.3 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein SpoIIP PF07454.11 CDI77633.1 - 0.0029 17.1 23.7 0.0061 16.0 18.9 2.2 2 0 0 2 2 2 1 Stage II sporulation protein P (SpoIIP) FAM176 PF14851.6 CDI77633.1 - 0.0031 17.2 16.8 0.19 11.4 0.3 2.4 2 0 0 2 2 2 2 FAM176 family Pex16 PF08610.10 CDI77633.1 - 0.0085 15.3 13.4 0.025 13.8 0.1 2.1 2 0 0 2 2 2 1 Peroxisomal membrane protein (Pex16) Lin-8 PF03353.15 CDI77633.1 - 0.018 14.6 37.7 0.024 14.2 23.4 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Band_3_cyto PF07565.13 CDI77633.1 - 0.034 13.9 27.1 0.58 9.9 20.7 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain FAM60A PF15396.6 CDI77633.1 - 0.07 13.1 26.3 0.74 9.8 18.9 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Connexin PF00029.19 CDI77633.1 - 0.071 12.9 19.2 0.076 12.8 15.4 2.1 2 0 0 2 2 2 0 Connexin Utp14 PF04615.13 CDI77633.1 - 0.073 11.6 29.4 0.29 9.7 22.3 2.0 2 0 0 2 2 2 0 Utp14 protein SNF5 PF04855.12 CDI77633.1 - 0.077 12.8 0.2 0.077 12.8 0.2 2.3 2 0 0 2 2 2 0 SNF5 / SMARCB1 / INI1 SRP-alpha_N PF04086.13 CDI77633.1 - 0.12 12.3 28.7 0.25 11.3 19.8 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal MDM10 PF12519.8 CDI77633.1 - 0.13 11.1 18.0 0.023 13.6 12.3 2.0 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 Anoctamin PF04547.12 CDI77633.1 - 0.14 11.0 10.1 0.093 11.5 8.7 1.4 1 1 0 1 1 1 0 Calcium-activated chloride channel OATP PF03137.20 CDI77633.1 - 0.16 10.2 18.9 0.21 9.8 18.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family LTV PF04180.14 CDI77633.1 - 0.35 10.6 25.1 0.32 10.7 15.9 2.1 2 0 0 2 2 2 0 Low temperature viability protein NPR3 PF03666.13 CDI77633.1 - 0.79 8.4 29.6 0.11 11.3 17.4 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 LptF_LptG PF03739.14 CDI77633.1 - 0.89 8.3 4.5 1.5 7.6 4.5 1.4 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG SOBP PF15279.6 CDI77633.1 - 1 9.9 26.6 0.9 10.1 17.4 2.1 2 0 0 2 2 2 0 Sine oculis-binding protein SUFU_C PF12470.8 CDI77633.1 - 1.2 9.1 20.4 1.6 8.8 12.7 2.3 2 0 0 2 2 2 0 Suppressor of Fused Gli/Ci N terminal binding domain DUF4746 PF15928.5 CDI77633.1 - 1.4 8.3 17.1 0.29 10.5 12.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) LRRC37AB_C PF14914.6 CDI77633.1 - 1.6 8.6 26.5 3.2 7.6 17.5 2.2 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Nucleoside_tran PF01733.18 CDI77633.1 - 2.2 7.6 12.8 4.1 6.7 7.5 2.2 2 0 0 2 2 2 0 Nucleoside transporter DUF3295 PF11702.8 CDI77633.1 - 3.5 6.9 36.1 2.4 7.4 26.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) Hid1 PF12722.7 CDI77633.1 - 5.2 5.1 29.0 1.9 6.5 21.3 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein DUF5523 PF17661.1 CDI77633.1 - 5.4 6.6 26.8 0.61 9.7 20.2 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5523) DUF4638 PF15472.6 CDI77633.1 - 6.8 6.3 25.1 0.49 10.1 16.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) AF-4 PF05110.13 CDI77633.1 - 6.8 4.6 49.8 1.1 7.2 28.6 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein CSG2 PF16965.5 CDI77633.1 - 9.6 5.0 27.4 2.1 7.2 16.4 2.1 1 1 0 2 2 2 0 Ceramide synthase regulator CRA PF06589.11 CDI77634.1 - 0.0093 16.1 1.3 0.0096 16.0 1.3 1.0 1 0 0 1 1 1 1 Circumsporozoite-related antigen (CRA) DUF1180 PF06679.12 CDI77634.1 - 0.022 15.2 5.5 0.023 15.1 5.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) GPR15L PF15854.5 CDI77634.1 - 0.025 14.8 1.9 0.029 14.6 1.9 1.1 1 0 0 1 1 1 0 G-protein coupled receptor ligand 15 TRAP_alpha PF03896.16 CDI77634.1 - 0.027 13.7 4.9 0.028 13.6 4.9 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.6 CDI77634.1 - 0.044 13.4 8.6 0.049 13.3 8.6 1.1 1 0 0 1 1 1 0 FAM176 family Conotoxin PF02950.17 CDI77634.1 - 0.061 14.3 5.3 0.061 14.3 5.3 2.0 1 1 1 2 2 2 0 Conotoxin CobT PF06213.12 CDI77634.1 - 0.13 11.6 16.6 0.14 11.6 16.6 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MMM1 PF10296.9 CDI77634.1 - 0.24 10.4 7.8 0.23 10.4 7.8 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 NicO PF03824.16 CDI77634.1 - 0.3 10.4 8.4 0.32 10.3 8.4 1.0 1 0 0 1 1 1 0 High-affinity nickel-transport protein 7TM_GPCR_Srw PF10324.9 CDI77634.1 - 0.32 10.3 1.0 0.36 10.1 1.0 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw V_ATPase_I PF01496.19 CDI77634.1 - 0.44 8.4 19.9 0.45 8.4 19.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pap_E4 PF02711.14 CDI77634.1 - 0.49 11.4 17.1 0.54 11.2 17.1 1.0 1 0 0 1 1 1 0 E4 protein SID-1_RNA_chan PF13965.6 CDI77634.1 - 0.54 8.6 7.8 0.55 8.6 7.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Scs3p PF10261.9 CDI77634.1 - 0.57 9.6 7.7 0.61 9.5 7.7 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM OATP PF03137.20 CDI77634.1 - 0.63 8.3 8.7 0.69 8.1 8.7 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CLN3 PF02487.17 CDI77634.1 - 1 8.3 13.0 1 8.3 13.0 1.0 1 0 0 1 1 1 0 CLN3 protein Connexin PF00029.19 CDI77634.1 - 1 9.1 14.3 1.1 8.9 14.3 1.0 1 0 0 1 1 1 0 Connexin Ctr PF04145.15 CDI77634.1 - 1.2 9.7 9.5 1.3 9.7 9.5 1.0 1 0 0 1 1 1 0 Ctr copper transporter family CBP_BcsG PF11658.8 CDI77634.1 - 1.3 7.4 11.2 1.3 7.3 11.2 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DUF4446 PF14584.6 CDI77634.1 - 1.3 9.0 9.5 1.4 8.9 9.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF4252 PF14060.6 CDI77634.1 - 1.4 8.8 6.5 2.6 7.9 6.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4252) CSG2 PF16965.5 CDI77634.1 - 1.7 7.5 9.2 1.7 7.5 9.2 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Serinc PF03348.15 CDI77634.1 - 1.7 7.5 8.8 1.7 7.5 8.8 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2828 PF11443.8 CDI77634.1 - 1.8 6.6 17.8 1.9 6.5 17.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Neur_chan_memb PF02932.16 CDI77634.1 - 2.4 8.1 14.5 2.5 8.1 14.5 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Folate_carrier PF01770.18 CDI77634.1 - 2.9 6.5 10.2 2.8 6.6 10.2 1.0 1 0 0 1 1 1 0 Reduced folate carrier Zip PF02535.22 CDI77634.1 - 3.1 6.9 12.3 3.3 6.8 12.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Mem_trans PF03547.18 CDI77634.1 - 3.3 6.0 5.6 3.6 5.9 5.6 1.0 1 0 0 1 1 1 0 Membrane transport protein PIP5K PF01504.18 CDI77634.1 - 4 6.6 16.1 4.3 6.5 16.1 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Peroxin-13_N PF04088.13 CDI77634.1 - 4 7.7 8.8 5.7 7.2 8.8 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF2149 PF09919.9 CDI77634.1 - 4.3 7.7 6.8 5.1 7.4 6.8 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) LRRC37AB_C PF14914.6 CDI77634.1 - 4.3 7.2 17.9 4.9 7.0 17.9 1.1 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF3959 PF13105.6 CDI77634.1 - 4.8 6.6 11.2 5.6 6.4 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) PigN PF04987.14 CDI77634.1 - 6.9 5.4 9.7 8.6 5.1 9.7 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Afi1 PF07792.12 CDI77634.1 - 9.7 6.7 18.1 11 6.5 18.1 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Ureide_permease PF07168.11 CDI77634.1 - 9.8 4.8 8.2 9.5 4.9 8.2 1.0 1 0 0 1 1 1 0 Ureide permease FA_desaturase PF00487.24 CDI77636.1 - 0.23 11.3 0.5 0.45 10.3 0.0 1.7 2 0 0 2 2 2 0 Fatty acid desaturase DivIC PF04977.15 CDI77636.1 - 0.26 11.1 19.4 0.034 13.9 4.3 3.0 2 0 0 2 2 2 0 Septum formation initiator PAT1 PF09770.9 CDI77638.1 - 3.7 5.7 91.5 5.6 5.1 91.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 V_ATPase_I PF01496.19 CDI77643.1 - 2e-30 105.5 10.8 1.2e-29 102.9 0.0 2.0 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family PLA2_B PF01735.18 CDI77643.1 - 0.018 13.5 0.5 0.032 12.6 0.5 1.3 1 0 0 1 1 1 0 Lysophospholipase catalytic domain Presenilin PF01080.17 CDI77643.1 - 0.058 12.2 15.0 0.24 10.1 2.5 2.2 2 0 0 2 2 2 0 Presenilin SUIM_assoc PF16619.5 CDI77643.1 - 0.073 13.1 0.0 0.073 13.1 0.0 5.8 4 2 0 4 4 3 0 Unstructured region C-term to UIM in Ataxin3 Spore_III_AB PF09548.10 CDI77643.1 - 0.26 11.4 0.1 0.26 11.4 0.1 3.0 3 0 0 3 3 2 0 Stage III sporulation protein AB (spore_III_AB) Tsg PF04668.12 CDI77643.1 - 0.6 10.8 0.0 0.6 10.8 0.0 3.0 3 0 0 3 3 3 0 Twisted gastrulation (Tsg) protein conserved region EPL1 PF10513.9 CDI77643.1 - 0.74 10.2 12.7 3.4 8.0 5.6 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like FAM60A PF15396.6 CDI77643.1 - 1.1 9.3 10.3 5.2 7.0 1.0 2.3 2 0 0 2 2 2 0 Protein Family FAM60A RPA43_OB PF17875.1 CDI77643.1 - 1.5 9.4 11.1 0.25 12.0 1.7 2.9 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I SRP-alpha_N PF04086.13 CDI77643.1 - 1.6 8.6 15.9 0.28 11.1 2.9 2.3 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal BORG_CEP PF14957.6 CDI77643.1 - 1.9 9.7 11.1 5.7 8.1 1.3 2.5 2 0 0 2 2 2 0 Cdc42 effector Gti1_Pac2 PF09729.9 CDI77643.1 - 5.3 7.1 11.7 2 8.5 0.9 2.3 2 0 0 2 2 2 0 Gti1/Pac2 family Mcm10 PF09332.11 CDI77643.1 - 7.2 5.9 21.5 1.3 8.4 4.8 2.3 2 0 0 2 2 2 0 Mcm10 replication factor Lin-8 PF03353.15 CDI77643.1 - 9.3 5.7 21.8 0.84 9.1 6.0 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Proteasome PF00227.26 CDI77650.1 - 4.7e-49 166.5 0.0 5.6e-49 166.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDI77650.1 - 3.7e-11 42.5 0.0 6.7e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature AAA_6 PF12774.7 CDI77652.1 - 7.9e-139 462.2 0.9 8.8e-131 435.7 0.0 4.8 4 1 1 5 5 5 2 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 CDI77652.1 - 4.2e-122 408.6 8.0 4.2e-122 408.6 8.0 3.8 3 1 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 CDI77652.1 - 9.6e-92 308.1 10.1 4.1e-61 207.3 0.1 7.6 5 1 1 6 6 6 2 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 CDI77652.1 - 2.1e-87 292.7 0.1 6.7e-87 291.1 0.1 2.0 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 CDI77652.1 - 8.5e-78 260.5 0.8 8.5e-78 260.5 0.8 2.6 2 0 0 2 2 2 1 ATP-binding dynein motor region MT PF12777.7 CDI77652.1 - 1.9e-39 135.7 15.3 1.9e-39 135.7 15.3 2.7 3 0 0 3 3 3 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 CDI77652.1 - 3.4e-23 82.0 0.1 3.7e-22 78.6 0.0 2.9 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 CDI77652.1 - 2e-20 73.1 3.8 5.4e-20 71.8 0.7 3.4 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 CDI77652.1 - 3.4e-19 68.9 1.4 3.9e-18 65.5 0.0 3.2 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 CDI77652.1 - 2.8e-14 53.3 0.1 4.6e-07 29.9 0.0 5.5 5 1 0 5 5 5 2 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 CDI77652.1 - 2.7e-11 43.3 0.7 7.5e-06 25.6 0.0 4.1 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_18 PF13238.6 CDI77652.1 - 0.0041 17.7 0.4 6.7 7.3 0.0 4.4 4 0 0 4 4 4 1 AAA domain AAA PF00004.29 CDI77652.1 - 0.0051 17.2 2.2 0.76 10.2 0.0 4.4 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 CDI77652.1 - 0.025 13.7 0.0 0.12 11.4 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein RNA_helicase PF00910.22 CDI77652.1 - 0.029 14.8 0.6 14 6.2 0.0 3.9 3 0 0 3 3 3 0 RNA helicase AAA_33 PF13671.6 CDI77652.1 - 0.034 14.3 0.8 3.1 7.9 0.0 3.5 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 CDI77652.1 - 0.042 13.9 0.1 0.35 11.0 0.0 2.8 3 0 0 3 3 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 CDI77652.1 - 0.068 12.9 1.1 0.65 9.8 0.1 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Nab2 PF11517.8 CDI77652.1 - 0.099 13.0 0.0 0.41 11.0 0.0 2.0 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) AAA_16 PF13191.6 CDI77652.1 - 0.18 12.2 7.7 16 5.8 0.0 5.5 6 0 0 6 6 5 0 AAA ATPase domain Mg_chelatase PF01078.21 CDI77652.1 - 0.18 11.2 0.2 0.66 9.3 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CDI77652.1 - 0.2 11.9 6.5 18 5.6 0.1 5.2 5 0 0 5 5 3 0 AAA domain Mac PF12464.8 CDI77652.1 - 6.6 7.1 6.1 5.1 7.4 0.2 3.6 3 0 0 3 3 3 0 Maltose acetyltransferase Dynein_C PF18199.1 CDI77653.1 - 1.8e-83 280.3 0.0 2.1e-83 280.1 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 CDI77653.1 - 1.8e-19 70.2 0.0 3.4e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Motilin_ghrelin PF04644.12 CDI77653.1 - 0.1 12.4 0.1 0.27 11.1 0.1 1.7 1 0 0 1 1 1 0 Motilin/ghrelin Chorein_N PF12624.7 CDI77654.1 - 2.2e-20 72.9 0.1 5.9e-20 71.5 0.1 1.8 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 CDI77654.1 - 1.3e-16 60.9 0.0 2.4e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 CDI77654.1 - 4.5e-13 49.2 0.0 1.9e-10 40.6 0.0 2.6 2 1 0 2 2 2 2 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13 PF16908.5 CDI77654.1 - 0.00038 20.3 0.0 0.00083 19.2 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal Lin0512_fam PF09585.10 CDI77654.1 - 0.013 15.6 0.0 0.57 10.2 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical protein (Lin0512_fam) RNA_pol_Rpc4 PF05132.14 CDI77697.1 - 2.7 8.4 13.9 2.8 8.4 13.9 1.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 Choline_kinase PF01633.20 CDI77705.1 - 3e-16 59.7 0.1 4.8e-10 39.4 0.0 2.1 2 0 0 2 2 2 2 Choline/ethanolamine kinase APH PF01636.23 CDI77705.1 - 2.1e-05 24.6 0.3 4.2e-05 23.6 0.3 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF2722 PF10846.8 CDI77705.1 - 0.036 13.0 16.0 0.058 12.3 16.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TERB2 PF15101.6 CDI77705.1 - 0.086 12.9 6.3 0.13 12.3 6.3 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TFIIA PF03153.13 CDI77705.1 - 0.1 12.6 14.8 0.14 12.1 14.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SpoIIP PF07454.11 CDI77705.1 - 0.16 11.4 6.4 0.21 11.0 6.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF3298 PF11738.8 CDI77705.1 - 0.6 11.2 4.0 1.3 10.1 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3298) DUF4175 PF13779.6 CDI77705.1 - 0.82 7.5 16.2 1 7.2 16.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Presenilin PF01080.17 CDI77705.1 - 0.84 8.3 5.8 1.2 7.9 5.8 1.1 1 0 0 1 1 1 0 Presenilin Folliculin PF11704.8 CDI77705.1 - 1.2 9.0 8.2 2 8.3 8.2 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport FTCD_C PF04961.12 CDI77705.1 - 1.2 8.8 3.8 1.9 8.2 3.8 1.2 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase DUF4834 PF16118.5 CDI77705.1 - 1.6 9.8 9.2 2.6 9.0 9.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Folate_carrier PF01770.18 CDI77705.1 - 1.7 7.3 2.7 2.3 6.8 2.7 1.1 1 0 0 1 1 1 0 Reduced folate carrier Fmp27 PF10344.9 CDI77705.1 - 1.8 6.6 6.5 2.3 6.2 6.5 1.1 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 CLN3 PF02487.17 CDI77705.1 - 2.5 7.0 3.3 3.6 6.5 3.3 1.1 1 0 0 1 1 1 0 CLN3 protein Spt20 PF12090.8 CDI77705.1 - 5.6 6.5 27.4 8.1 6.0 27.4 1.1 1 0 0 1 1 1 0 Spt20 family EIIBC-GUT_N PF03612.14 CDI77705.1 - 7.2 6.3 6.2 11 5.8 6.2 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus LCD1 PF09798.9 CDI77714.1 - 0.0026 16.4 22.3 0.0026 16.4 22.3 15.0 2 1 10 12 12 12 1 DNA damage checkpoint protein DUF4407 PF14362.6 CDI77714.1 - 0.0038 16.6 41.7 0.0038 16.6 41.7 10.1 1 1 10 11 11 11 1 Domain of unknown function (DUF4407) Phage_1_1 PF08200.11 CDI77714.1 - 4.4 7.8 7.1 2e+02 2.5 7.1 4.2 1 0 0 1 1 1 0 Bacteriophage 1.1 Protein Pex14_N PF04695.13 CDI77720.1 - 0.00069 20.3 26.6 0.00085 20.0 26.6 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Connexin PF00029.19 CDI77720.1 - 0.0081 16.0 14.5 0.0096 15.7 14.5 1.0 1 0 0 1 1 1 1 Connexin Presenilin PF01080.17 CDI77720.1 - 0.0083 14.9 19.3 0.0094 14.8 19.3 1.2 1 0 0 1 1 1 1 Presenilin DUF5308 PF17233.2 CDI77720.1 - 0.0092 16.2 12.9 0.011 16.0 12.9 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5308) FAM176 PF14851.6 CDI77720.1 - 0.01 15.5 7.3 0.012 15.3 7.3 1.2 1 0 0 1 1 1 0 FAM176 family PBP1_TM PF14812.6 CDI77720.1 - 0.012 16.0 5.0 0.015 15.7 5.0 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SpoIIP PF07454.11 CDI77720.1 - 0.016 14.7 18.5 0.016 14.7 18.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4366 PF14283.6 CDI77720.1 - 0.019 15.0 8.5 0.021 14.9 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) SARAF PF06682.12 CDI77720.1 - 0.027 14.1 15.9 0.028 14.1 15.9 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Peptidase_S49_N PF08496.10 CDI77720.1 - 0.029 14.5 13.6 0.039 14.0 13.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CCSAP PF15748.5 CDI77720.1 - 0.031 14.5 18.2 0.032 14.4 18.2 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated HCO3_cotransp PF00955.21 CDI77720.1 - 0.036 12.9 6.9 0.041 12.7 6.9 1.0 1 0 0 1 1 1 0 HCO3- transporter family CPSF100_C PF13299.6 CDI77720.1 - 0.036 14.2 14.2 0.041 14.1 14.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal TRAP_alpha PF03896.16 CDI77720.1 - 0.039 13.2 6.4 0.041 13.1 6.4 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Endostatin PF06482.11 CDI77720.1 - 0.039 13.4 17.0 0.045 13.2 17.0 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Serinc PF03348.15 CDI77720.1 - 0.04 12.9 10.1 0.043 12.8 10.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Tim54 PF11711.8 CDI77720.1 - 0.04 12.7 15.2 0.044 12.6 15.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2828 PF11443.8 CDI77720.1 - 0.043 11.9 16.9 0.043 11.9 16.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DcuA_DcuB PF03605.14 CDI77720.1 - 0.048 12.6 5.3 0.06 12.2 5.3 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF913 PF06025.12 CDI77720.1 - 0.056 12.4 11.2 0.058 12.4 11.2 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Kei1 PF08552.11 CDI77720.1 - 0.059 13.3 12.3 0.072 13.0 12.3 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Peptidase_M56 PF05569.11 CDI77720.1 - 0.06 12.5 2.1 0.068 12.4 2.1 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 MCD PF05292.11 CDI77720.1 - 0.063 12.8 11.6 0.073 12.6 11.6 1.0 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain CLN3 PF02487.17 CDI77720.1 - 0.089 11.8 14.2 0.1 11.7 14.2 1.0 1 0 0 1 1 1 0 CLN3 protein FYDLN_acid PF09538.10 CDI77720.1 - 0.096 13.4 9.8 0.12 13.0 9.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) FTO_NTD PF12933.7 CDI77720.1 - 0.096 11.9 10.6 0.12 11.6 10.6 1.1 1 0 0 1 1 1 0 FTO catalytic domain Velvet PF11754.8 CDI77720.1 - 0.098 12.6 16.5 0.1 12.5 16.5 1.0 1 0 0 1 1 1 0 Velvet factor DUF2370 PF10176.9 CDI77720.1 - 0.098 12.3 8.4 0.11 12.2 8.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Band_3_cyto PF07565.13 CDI77720.1 - 0.11 12.3 16.4 0.11 12.2 16.4 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RR_TM4-6 PF06459.12 CDI77720.1 - 0.11 12.3 19.5 0.12 12.1 19.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 CDI77720.1 - 0.11 10.7 14.4 0.12 10.7 14.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Ureide_permease PF07168.11 CDI77720.1 - 0.11 11.2 6.7 0.14 10.9 6.7 1.2 1 0 0 1 1 1 0 Ureide permease Peroxin-3 PF04882.12 CDI77720.1 - 0.12 11.3 21.3 0.14 11.1 21.3 1.0 1 0 0 1 1 1 0 Peroxin-3 OATP PF03137.20 CDI77720.1 - 0.14 10.5 8.8 0.16 10.2 8.8 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Maf1 PF09174.10 CDI77720.1 - 0.14 12.3 11.9 0.17 12.0 11.9 1.1 1 0 0 1 1 1 0 Maf1 regulator CSG2 PF16965.5 CDI77720.1 - 0.14 11.1 10.3 0.16 10.9 10.3 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator SLC12 PF03522.15 CDI77720.1 - 0.14 11.1 18.0 0.14 11.1 18.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF5523 PF17661.1 CDI77720.1 - 0.17 11.6 18.5 0.17 11.5 18.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF3984 PF13136.6 CDI77720.1 - 0.17 11.2 13.0 0.2 11.0 13.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) EOS1 PF12326.8 CDI77720.1 - 0.18 11.7 9.4 0.24 11.3 9.4 1.3 1 0 0 1 1 1 0 N-glycosylation protein Gti1_Pac2 PF09729.9 CDI77720.1 - 0.2 11.7 14.7 0.23 11.5 14.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DDHD PF02862.17 CDI77720.1 - 0.21 11.7 16.1 0.23 11.6 16.1 1.1 1 0 0 1 1 1 0 DDHD domain Sec62 PF03839.16 CDI77720.1 - 0.25 10.8 14.3 0.26 10.7 14.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Eapp_C PF10238.9 CDI77720.1 - 0.26 11.4 19.7 0.34 11.0 19.7 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein Pkinase_fungal PF17667.1 CDI77720.1 - 0.26 10.0 9.7 0.26 10.0 9.7 1.0 1 0 0 1 1 1 0 Fungal protein kinase PAT1 PF09770.9 CDI77720.1 - 0.27 9.5 33.3 0.28 9.4 33.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TCRP1 PF14944.6 CDI77720.1 - 0.29 11.1 4.7 0.31 11.0 4.7 1.0 1 0 0 1 1 1 0 Tongue Cancer Chemotherapy Resistant Protein 1 LAP1C PF05609.12 CDI77720.1 - 0.3 10.1 20.8 0.34 10.0 20.8 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF2561 PF10812.8 CDI77720.1 - 0.31 11.1 2.3 0.4 10.7 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) Peptidase_S64 PF08192.11 CDI77720.1 - 0.34 9.3 14.7 0.35 9.3 14.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF3292 PF11696.8 CDI77720.1 - 0.35 9.2 13.3 0.38 9.1 13.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) TFIIA PF03153.13 CDI77720.1 - 0.35 10.8 49.9 0.4 10.6 49.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM60A PF15396.6 CDI77720.1 - 0.36 10.8 14.2 0.4 10.7 14.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CBP_BcsG PF11658.8 CDI77720.1 - 0.36 9.2 14.9 0.38 9.1 14.9 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG PPL5 PF18168.1 CDI77720.1 - 0.36 10.1 12.5 0.39 10.0 12.5 1.0 1 0 0 1 1 1 0 Prim-pol family 5 MMM1 PF10296.9 CDI77720.1 - 0.36 9.8 11.5 0.41 9.6 11.5 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Membralin PF09746.9 CDI77720.1 - 0.39 9.7 13.5 0.39 9.7 13.5 1.0 1 0 0 1 1 1 0 Tumour-associated protein Scs3p PF10261.9 CDI77720.1 - 0.39 10.2 7.2 0.46 10.0 7.2 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM SID-1_RNA_chan PF13965.6 CDI77720.1 - 0.42 9.0 10.0 0.44 8.9 10.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CCDC53 PF10152.9 CDI77720.1 - 0.47 10.9 21.3 0.56 10.6 21.3 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Lin-8 PF03353.15 CDI77720.1 - 0.49 9.9 24.0 0.5 9.9 24.0 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2126 PF09899.9 CDI77720.1 - 0.5 8.4 15.1 0.55 8.2 15.1 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) ALMT PF11744.8 CDI77720.1 - 0.5 9.1 14.4 0.54 9.0 14.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter TERB2 PF15101.6 CDI77720.1 - 0.53 10.3 27.2 0.77 9.8 27.2 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4407 PF14362.6 CDI77720.1 - 0.54 9.6 23.5 0.6 9.4 23.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TFB6 PF17110.5 CDI77720.1 - 0.57 9.9 9.8 0.76 9.5 9.8 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Pal1 PF08316.11 CDI77720.1 - 0.58 10.9 8.0 0.69 10.7 8.0 1.2 1 0 0 1 1 1 0 Pal1 cell morphology protein TMEM144 PF07857.12 CDI77720.1 - 0.61 9.0 2.1 0.71 8.8 2.1 1.1 1 0 0 1 1 1 0 Transmembrane family, TMEM144 of transporters NPR3 PF03666.13 CDI77720.1 - 0.64 8.7 17.9 0.71 8.6 17.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Afi1 PF07792.12 CDI77720.1 - 0.67 10.4 18.1 0.83 10.1 18.1 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF1644 PF07800.12 CDI77720.1 - 0.69 10.0 16.6 1.9 8.5 16.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) Peptidase_S15 PF02129.18 CDI77720.1 - 0.78 9.3 14.5 0.8 9.2 14.5 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) MAT1 PF06391.13 CDI77720.1 - 0.8 9.5 27.2 0.93 9.3 27.2 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 BORG_CEP PF14957.6 CDI77720.1 - 0.85 10.8 12.5 1 10.6 12.5 1.1 1 0 0 1 1 1 0 Cdc42 effector PIP5K PF01504.18 CDI77720.1 - 0.87 8.8 18.5 1.1 8.5 18.5 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase NARP1 PF12569.8 CDI77720.1 - 0.88 8.4 18.8 1 8.2 18.8 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Zip PF02535.22 CDI77720.1 - 0.92 8.7 9.7 1 8.5 9.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Pannexin_like PF12534.8 CDI77720.1 - 1 8.4 14.6 1 8.3 14.6 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF4050 PF13259.6 CDI77720.1 - 1 9.7 16.7 1.2 9.4 16.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) eIF-3_zeta PF05091.12 CDI77720.1 - 1 8.2 28.7 1.2 8.0 28.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Nucleoside_tran PF01733.18 CDI77720.1 - 1.1 8.6 9.6 1.3 8.3 9.6 1.0 1 0 0 1 1 1 0 Nucleoside transporter HemX PF04375.14 CDI77720.1 - 1.2 8.4 40.7 1.1 8.4 40.7 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Folate_carrier PF01770.18 CDI77720.1 - 1.2 7.8 12.0 1.5 7.5 12.0 1.1 1 0 0 1 1 1 0 Reduced folate carrier Gastrin PF00918.17 CDI77720.1 - 1.2 10.1 15.2 1.3 10.0 15.2 1.1 1 0 0 1 1 1 0 Gastrin/cholecystokinin family CemA PF03040.14 CDI77720.1 - 1.3 9.0 10.1 1.4 8.8 10.1 1.1 1 0 0 1 1 1 0 CemA family XRN_M PF17846.1 CDI77720.1 - 1.4 7.8 12.5 1.5 7.7 12.5 1.0 1 0 0 1 1 1 0 Xrn1 helical domain ArsP_2 PF11449.8 CDI77720.1 - 1.4 8.0 9.6 1.8 7.7 9.6 1.3 1 1 0 1 1 1 0 Putative, 10TM heavy-metal exporter Bul1_N PF04425.12 CDI77720.1 - 1.5 7.5 16.2 1.6 7.4 16.2 1.0 1 0 0 1 1 1 0 Bul1 N terminus Paramyxo_ncap PF00973.19 CDI77720.1 - 1.7 7.5 13.3 1.7 7.5 13.3 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Cellulose_synt PF03552.14 CDI77720.1 - 1.7 7.0 8.6 1.8 7.0 8.6 1.0 1 0 0 1 1 1 0 Cellulose synthase Neur_chan_memb PF02932.16 CDI77720.1 - 1.8 8.6 16.9 2 8.4 16.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4638 PF15472.6 CDI77720.1 - 1.9 8.1 17.5 2 8.1 17.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) GvpL_GvpF PF06386.11 CDI77720.1 - 2 8.3 15.2 2.5 8.0 15.2 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Spore_coat_CotO PF14153.6 CDI77720.1 - 2 8.3 28.9 2.4 8.1 28.9 1.1 1 0 0 1 1 1 0 Spore coat protein CotO RICTOR_N PF14664.6 CDI77720.1 - 2.1 7.2 8.3 3 6.7 8.3 1.3 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term Hydin_ADK PF17213.3 CDI77720.1 - 2.2 8.5 15.7 2.7 8.2 15.7 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain STAC2_u1 PF16664.5 CDI77720.1 - 2.2 8.7 16.7 2.8 8.4 16.7 1.1 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 MMU163 PF17119.5 CDI77720.1 - 2.2 7.4 9.1 2.6 7.1 9.1 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DUF5385 PF17359.2 CDI77720.1 - 2.3 7.7 23.4 5.8 6.4 23.4 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5385) DUF1764 PF08576.10 CDI77720.1 - 2.4 9.1 17.4 3.7 8.5 17.4 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) MAJIN PF15077.6 CDI77720.1 - 2.5 7.8 13.9 2.6 7.7 13.9 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein PTPRCAP PF15713.5 CDI77720.1 - 2.7 8.3 21.6 3.2 8.0 21.6 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF4228 PF14009.6 CDI77720.1 - 2.7 8.3 9.6 3 8.2 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) V_ATPase_I PF01496.19 CDI77720.1 - 3 5.7 24.7 3.5 5.4 24.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LptF_LptG PF03739.14 CDI77720.1 - 3.3 6.5 5.3 3.7 6.3 5.3 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG PepSY_TM PF03929.16 CDI77720.1 - 3.4 7.3 11.6 4.3 6.9 11.6 1.3 1 0 0 1 1 1 0 PepSY-associated TM region MCU PF04678.13 CDI77720.1 - 3.5 7.7 16.2 5.5 7.1 16.2 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Otopetrin PF03189.13 CDI77720.1 - 3.6 6.3 15.1 4 6.2 15.1 1.0 1 0 0 1 1 1 0 Otopetrin Folliculin PF11704.8 CDI77720.1 - 3.6 7.4 17.6 4.1 7.2 17.6 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF4746 PF15928.5 CDI77720.1 - 3.7 6.9 15.7 4.3 6.7 15.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) GREB1 PF15782.5 CDI77720.1 - 3.7 4.5 20.8 3.9 4.5 20.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Asparaginase_2 PF01112.18 CDI77720.1 - 4.4 6.2 10.9 5.2 6.0 10.9 1.2 1 0 0 1 1 1 0 Asparaginase FliP PF00813.20 CDI77720.1 - 4.5 7.1 12.1 5.2 6.9 12.1 1.0 1 0 0 1 1 1 0 FliP family PRC2_HTH_1 PF18118.1 CDI77720.1 - 4.5 8.1 14.6 6.8 7.6 14.6 1.3 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain HD-ZIP_N PF04618.12 CDI77720.1 - 4.7 7.8 10.0 6 7.4 10.0 1.2 1 0 0 1 1 1 0 HD-ZIP protein N terminus Ndc1_Nup PF09531.10 CDI77720.1 - 4.9 5.7 16.5 5.2 5.6 16.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MDM10 PF12519.8 CDI77720.1 - 5.1 5.8 18.6 5.6 5.7 18.6 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DDRGK PF09756.9 CDI77720.1 - 5.3 6.6 33.1 7.1 6.2 33.1 1.1 1 0 0 1 1 1 0 DDRGK domain EMC3_TMCO1 PF01956.16 CDI77720.1 - 5.4 6.7 21.1 6.6 6.4 21.1 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Peptidase_U57 PF05582.12 CDI77720.1 - 5.7 6.1 16.0 6.9 5.8 16.0 1.1 1 0 0 1 1 1 0 YabG peptidase U57 DUF853 PF05872.12 CDI77720.1 - 6.4 5.2 15.9 7.4 5.0 15.9 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF2072 PF09845.9 CDI77720.1 - 6.8 7.0 16.3 8.7 6.6 16.3 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein LMBR1 PF04791.16 CDI77720.1 - 6.8 5.5 14.0 7.4 5.4 14.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2464 PF10240.9 CDI77720.1 - 7.1 6.1 14.0 8.2 5.9 14.0 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 Tmem26 PF09772.9 CDI77720.1 - 7.2 5.9 10.1 8.5 5.6 10.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 26 AUX_IAA PF02309.16 CDI77720.1 - 7.6 6.3 13.3 8.4 6.2 13.3 1.1 1 0 0 1 1 1 0 AUX/IAA family ABC2_membrane_3 PF12698.7 CDI77720.1 - 8.3 5.4 8.9 9.3 5.3 8.9 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein 5_nucleotid PF05761.14 CDI77720.1 - 8.3 5.2 17.7 9.1 5.1 17.7 1.0 1 0 0 1 1 1 0 5' nucleotidase family CTU2 PF10288.9 CDI77720.1 - 8.6 6.6 20.9 14 6.0 20.9 1.3 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Exonuc_VII_L PF02601.15 CDI77720.1 - 8.7 5.8 22.4 8.9 5.8 22.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sugar_tr PF00083.24 CDI77720.1 - 8.8 5.1 7.3 9.3 5.0 7.3 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter UPF0560 PF10577.9 CDI77720.1 - 8.9 4.7 34.2 10 4.5 34.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF3408 PF11888.8 CDI77720.1 - 9.1 6.4 21.8 16 5.6 21.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF4338 PF14236.6 CDI77720.1 - 9.2 5.4 14.2 11 5.2 14.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4338) DUF3537 PF12056.8 CDI77720.1 - 9.9 4.9 11.5 11 4.7 11.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) DIM1 PF02966.16 CDI77728.1 - 2.2e-66 221.7 0.5 2.4e-66 221.5 0.5 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 CDI77728.1 - 0.0027 17.7 0.1 0.0036 17.3 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin IMP2_N PF18590.1 CDI77750.1 - 8.1e-20 71.2 0.0 1.4e-19 70.4 0.0 1.4 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain Herpes_UL56 PF04534.12 CDI77752.1 - 0.11 12.0 0.1 0.26 10.7 0.1 1.7 1 1 0 1 1 1 0 Herpesvirus UL56 protein DUF2722 PF10846.8 CDI77760.1 - 0.00056 19.0 0.7 0.00056 19.0 0.7 5.0 4 1 0 4 4 4 3 Protein of unknown function (DUF2722) Nucleoporin2 PF04096.14 CDI77760.1 - 0.045 13.9 0.2 0.045 13.9 0.2 3.4 4 0 0 4 4 4 0 Nucleoporin autopeptidase DUF4834 PF16118.5 CDI77760.1 - 0.66 11.0 26.0 4.8 8.2 0.3 5.6 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) DUF2722 PF10846.8 CDI77768.1 - 5.8e-09 35.4 125.0 7e-05 22.0 14.2 6.3 6 0 0 6 6 6 6 Protein of unknown function (DUF2722) DUF4207 PF13904.6 CDI77768.1 - 0.01 15.5 9.4 0.01 15.5 9.4 6.5 6 1 0 6 6 6 0 Domain of unknown function (DUF4207) SR-25 PF10500.9 CDI77806.1 - 4.4 6.9 64.8 0.86 9.2 14.4 2.5 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein Rrn6 PF10214.9 CDI77806.1 - 8.2 4.8 35.3 9.4 4.6 35.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor RskA PF10099.9 CDI77809.1 - 0.002 18.4 37.9 0.072 13.4 36.1 2.3 1 1 1 2 2 2 1 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI77809.1 - 0.022 14.8 6.2 0.022 14.8 6.2 3.5 2 1 0 2 2 1 0 Unstructured region C-term to UIM in Ataxin3 DUF4207 PF13904.6 CDI77809.1 - 0.03 14.0 34.8 0.058 13.1 34.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4207) DUF4386 PF14329.6 CDI77809.1 - 0.041 13.7 0.6 0.059 13.2 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) PPP4R2 PF09184.11 CDI77809.1 - 0.064 12.8 20.0 0.098 12.2 20.0 1.2 1 0 0 1 1 1 0 PPP4R2 Spt20 PF12090.8 CDI77809.1 - 0.19 11.3 31.4 0.33 10.5 9.4 2.3 2 0 0 2 2 2 0 Spt20 family MFS_2 PF13347.6 CDI77809.1 - 0.2 10.1 0.4 0.29 9.7 0.4 1.2 1 0 0 1 1 1 0 MFS/sugar transport protein DUF4123 PF13503.6 CDI77809.1 - 0.22 12.0 8.8 0.38 11.2 8.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4123) Bap31 PF05529.12 CDI77809.1 - 0.41 10.5 2.4 0.66 9.8 0.0 2.0 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region CD20 PF04103.15 CDI77809.1 - 0.43 10.7 0.0 0.43 10.7 0.0 2.9 2 1 0 2 2 1 0 CD20-like family PAP_RNA-bind PF04926.15 CDI77809.1 - 0.73 9.4 9.1 0.85 9.2 2.2 2.3 2 0 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain EphA2_TM PF14575.6 CDI77809.1 - 0.76 10.7 0.1 0.76 10.7 0.1 3.3 2 1 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4813 PF16072.5 CDI77809.1 - 1 9.0 18.6 1.5 8.5 18.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Porph_ging PF09697.10 CDI77809.1 - 1.7 9.2 5.6 4.9 7.8 1.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) AP3D1 PF06375.11 CDI77809.1 - 2.9 8.1 23.4 6.1 7.1 0.2 2.4 2 1 0 2 2 2 0 AP-3 complex subunit delta-1 FHIPEP PF00771.20 CDI77816.1 - 1.5 7.2 13.6 1.7 7.0 13.6 1.2 1 0 0 1 1 1 0 FHIPEP family Membralin PF09746.9 CDI77816.1 - 7.2 5.5 13.8 9.2 5.2 13.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein Ank_3 PF13606.6 CDI77845.1 - 0.068 13.8 0.0 0.15 12.7 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeat Mitofilin PF09731.9 CDI77845.1 - 0.92 8.3 28.4 1.2 7.9 28.4 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF966 PF06136.13 CDI77845.1 - 1.4 8.6 16.0 1.6 8.4 16.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) BAF1_ABF1 PF04684.13 CDI77845.1 - 1.5 7.8 19.1 2 7.4 19.1 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor WDCP PF15390.6 CDI77845.1 - 2.3 6.5 11.2 2.7 6.3 11.2 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Draxin PF15550.6 CDI77845.1 - 2.7 7.8 11.6 3.8 7.3 11.6 1.2 1 0 0 1 1 1 0 Draxin Miga PF10265.9 CDI77845.1 - 4.4 6.2 9.6 5.3 5.9 9.6 1.1 1 0 0 1 1 1 0 Mitoguardin DUF572 PF04502.13 CDI77845.1 - 5.2 6.6 18.0 6.6 6.3 18.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SLC12 PF03522.15 CDI77845.1 - 9 5.2 12.8 11 4.9 12.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 CDI77845.1 - 9.3 4.9 11.7 12 4.6 11.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Dapper PF15268.6 CDI77846.1 - 0.00083 18.4 30.3 0.00089 18.3 30.3 1.1 1 0 0 1 1 1 1 Dapper Ndc1_Nup PF09531.10 CDI77846.1 - 0.0015 17.4 23.6 0.0016 17.2 23.6 1.2 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Caldesmon PF02029.15 CDI77846.1 - 0.0041 16.0 32.1 0.0047 15.8 32.1 1.1 1 0 0 1 1 1 1 Caldesmon Apt1 PF10351.9 CDI77846.1 - 0.015 14.2 14.9 0.02 13.8 14.9 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain PNISR PF15996.5 CDI77846.1 - 0.02 15.2 39.4 0.032 14.5 39.4 1.4 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF966 PF06136.13 CDI77846.1 - 0.047 13.4 21.9 0.06 13.1 21.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Sin_N PF04801.13 CDI77846.1 - 0.059 12.6 44.4 0.12 11.5 44.4 1.6 1 0 0 1 1 1 0 Sin-like protein conserved region DUF2981 PF11200.8 CDI77846.1 - 0.22 11.3 12.7 0.38 10.4 12.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) SAGA-Tad1 PF12767.7 CDI77846.1 - 0.91 9.2 28.4 1.5 8.5 28.4 1.3 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit LAP1C PF05609.12 CDI77846.1 - 1.2 8.1 36.7 1.7 7.7 36.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PAT1 PF09770.9 CDI77846.1 - 1.4 7.1 53.4 2 6.6 53.4 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.10 CDI77846.1 - 1.6 7.4 77.5 2.1 7.0 77.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Raftlin PF15250.6 CDI77846.1 - 2.1 7.0 31.5 3 6.5 31.5 1.2 1 0 0 1 1 1 0 Raftlin DUF4045 PF13254.6 CDI77846.1 - 2.5 7.7 33.1 3.9 7.0 33.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CDC45 PF02724.14 CDI77846.1 - 3 6.0 33.4 4.5 5.5 33.4 1.2 1 0 0 1 1 1 0 CDC45-like protein SWI-SNF_Ssr4 PF08549.10 CDI77846.1 - 5.7 5.4 37.0 8.8 4.8 37.0 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) SLC12 PF03522.15 CDI77846.1 - 8 5.4 36.6 14 4.6 36.6 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Asp-B-Hydro_N PF05279.11 CDI77846.1 - 8.8 6.3 33.9 14 5.6 33.9 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CW_7 PF08230.11 CDI77877.1 - 0.0085 15.8 0.9 0.016 15.0 0.9 1.3 1 0 0 1 1 1 1 CW_7 repeat gag-asp_proteas PF13975.6 CDI77879.1 - 0.00037 21.0 0.0 0.001 19.6 0.0 1.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDI77879.1 - 0.0031 18.1 0.0 0.0067 17.0 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 CDI77879.1 - 0.23 11.2 0.0 0.34 10.7 0.0 1.2 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF2722 PF10846.8 CDI77885.1 - 0.018 14.0 0.7 0.018 14.0 0.7 5.0 2 1 3 5 5 5 0 Protein of unknown function (DUF2722) Cwf_Cwc_15 PF04889.12 CDI77885.1 - 1.8 8.2 37.4 0.091 12.5 29.0 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein TCP PF03634.13 CDI77885.1 - 2.7 8.6 36.9 0.41 11.2 7.5 3.2 3 0 0 3 3 3 0 TCP family transcription factor SOBP PF15279.6 CDI77889.1 - 0.025 15.2 21.7 0.028 15.0 21.7 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein PAT1 PF09770.9 CDI77889.1 - 0.047 12.0 28.5 0.049 11.9 28.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Lin-8 PF03353.15 CDI77889.1 - 0.12 11.9 11.3 0.14 11.7 11.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ten_N PF06484.12 CDI77889.1 - 0.15 11.9 7.3 0.17 11.7 7.3 1.3 1 0 0 1 1 1 0 Teneurin Intracellular Region DUF4175 PF13779.6 CDI77889.1 - 0.2 9.5 32.9 0.27 9.1 32.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF908 PF06012.12 CDI77889.1 - 1.1 8.6 9.4 1.2 8.5 9.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) GREB1 PF15782.5 CDI77889.1 - 4.6 4.2 12.1 5.1 4.1 12.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 CDI77889.1 - 5.4 5.7 14.3 8 5.1 14.3 1.3 1 0 0 1 1 1 0 Presenilin Sin_N PF04801.13 CDI77889.1 - 5.8 6.0 23.1 9.9 5.3 23.1 1.4 1 0 0 1 1 1 0 Sin-like protein conserved region ALMT PF11744.8 CDI77889.1 - 6 5.6 6.2 7.3 5.3 6.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter eIF-3_zeta PF05091.12 CDI77889.1 - 7.8 5.3 13.9 11 4.9 13.9 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_S15 PF02129.18 CDI77889.1 - 8.4 5.9 16.1 0.12 12.0 8.4 1.8 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Hid1 PF12722.7 CDI77889.1 - 9.5 4.2 10.1 10 4.1 10.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein N6_N4_Mtase PF01555.18 CDI77890.1 - 0.29 10.8 2.6 11 5.6 0.6 3.2 2 1 0 2 2 2 0 DNA methylase Peptidase_S64 PF08192.11 CDI77916.1 - 0.51 8.8 47.7 0.59 8.5 47.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 SR-25 PF10500.9 CDI77916.1 - 2.5 7.7 44.6 0.069 12.7 34.6 2.0 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein PI3K_1B_p101 PF10486.9 CDI77916.1 - 2.8 5.6 26.4 4 5.1 26.4 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Cwf_Cwc_15 PF04889.12 CDI77916.1 - 3.1 7.5 45.6 4.6 6.9 45.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SelP_N PF04592.14 CDI77926.1 - 0.071 12.5 27.6 0.081 12.3 27.6 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PvlArgDC PF01862.16 CDI77926.1 - 5.3 6.8 8.3 12 5.7 8.3 1.6 1 1 0 1 1 1 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) Endostatin PF06482.11 CDI77926.1 - 5.4 6.4 24.6 5.5 6.4 24.6 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Presenilin PF01080.17 CDI77926.1 - 7.4 5.2 32.7 7.8 5.1 32.7 1.0 1 0 0 1 1 1 0 Presenilin NicO PF03824.16 CDI77926.1 - 9.4 5.5 5.2 11 5.3 5.2 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein Ribosomal_60s PF00428.19 CDI77927.1 - 0.0068 17.0 2.2 0.0068 17.0 2.2 3.4 4 0 0 4 4 4 2 60s Acidic ribosomal protein Fer4_22 PF17179.4 CDI77927.1 - 0.79 10.6 0.1 0.79 10.6 0.1 3.0 2 1 0 2 2 2 0 4Fe-4S dicluster domain HECT PF00632.25 CDI77954.1 - 1.7e-53 182.2 0.0 3.5e-53 181.1 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) GILT PF03227.16 CDI77954.1 - 7.8e-21 74.3 0.1 2e-20 73.0 0.1 1.7 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) PAT1 PF09770.9 CDI77962.1 - 0.63 8.2 71.2 0.7 8.1 71.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 CDI77962.1 - 3.3 6.6 47.4 4.1 6.3 47.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SRP-alpha_N PF04086.13 CDI77962.1 - 3.6 7.4 37.0 4.8 7.0 37.0 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ndc1_Nup PF09531.10 CDI77962.1 - 4.4 5.9 39.8 4.9 5.7 39.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SAPS PF04499.15 CDI77962.1 - 4.4 6.0 33.2 5.4 5.7 33.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 CDI77962.1 - 6.6 4.9 38.9 9 4.5 38.9 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.6 CDI77962.1 - 7.9 6.0 37.0 10 5.6 37.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) AAA_12 PF13087.6 CDI77964.1 - 3e-36 124.9 0.1 3e-36 124.9 0.1 3.3 2 1 1 3 3 3 1 AAA domain BTRD1 PF17660.1 CDI77968.1 - 0.11 12.3 0.0 17 5.3 0.0 2.5 2 0 0 2 2 2 0 Bacterial tandem repeat domain 1 RskA PF10099.9 CDI77977.1 - 8.4e-05 22.9 13.3 8.4e-05 22.9 13.3 4.8 1 1 2 3 3 3 1 Anti-sigma-K factor rskA CDC27 PF09507.10 CDI77977.1 - 0.18 11.2 49.7 0.27 10.6 49.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 LAP1C PF05609.12 CDI77977.1 - 0.35 9.9 52.2 0.45 9.6 52.2 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) LMBR1 PF04791.16 CDI77977.1 - 1.9 7.3 25.4 2.3 7.0 25.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Dapper PF15268.6 CDI77977.1 - 3.7 6.3 63.5 4.5 6.0 63.5 1.1 1 0 0 1 1 1 0 Dapper AbLIM_anchor PF16182.5 CDI77977.1 - 5.4 6.7 42.8 7.4 6.3 42.8 1.2 1 0 0 1 1 1 0 Putative adherens-junction anchoring region of AbLIM PIP5K PF01504.18 CDI77984.1 - 0.00012 21.4 1.9 0.00012 21.4 1.9 2.2 1 1 1 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase AAA_23 PF13476.6 CDI77984.1 - 0.0019 18.8 24.2 0.0026 18.3 24.2 1.2 1 0 0 1 1 1 1 AAA domain DUF2244 PF10003.9 CDI77984.1 - 0.16 11.7 2.1 0.34 10.6 2.1 1.6 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) NPR3 PF03666.13 CDI77984.1 - 2.6 6.7 36.1 1.9 7.2 10.0 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC12 PF03522.15 CDI77984.1 - 4.1 6.3 33.2 1.2 8.0 15.5 2.2 2 0 0 2 2 2 0 Solute carrier family 12 DUF2207 PF09972.9 CDI77988.1 - 0.0032 16.3 0.8 0.0034 16.2 0.8 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Orf78 PF06024.12 CDI77988.1 - 0.02 15.2 4.5 0.02 15.2 4.5 2.1 1 1 1 2 2 2 0 Orf78 (ac78) Tweety PF04906.13 CDI77988.1 - 0.56 8.8 23.0 0.67 8.5 23.0 1.0 1 0 0 1 1 1 0 Tweety ABC2_membrane_3 PF12698.7 CDI77988.1 - 0.69 9.0 12.1 0.99 8.4 12.1 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein TMEM154 PF15102.6 CDI77988.1 - 0.7 9.8 6.7 1 9.3 6.6 1.5 1 1 0 1 1 1 0 TMEM154 protein family MDFI PF15316.6 CDI77988.1 - 0.77 9.8 5.9 0.92 9.6 5.9 1.2 1 0 0 1 1 1 0 MyoD family inhibitor HCO3_cotransp PF00955.21 CDI77988.1 - 0.78 8.5 11.2 0.84 8.4 11.2 1.0 1 0 0 1 1 1 0 HCO3- transporter family Neur_chan_memb PF02932.16 CDI77988.1 - 1.5 8.8 7.1 1.6 8.7 7.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LAP1C PF05609.12 CDI77988.1 - 2.3 7.2 19.4 2.6 7.0 19.4 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF3619 PF12279.8 CDI77988.1 - 2.5 8.4 18.8 3.1 8.1 18.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) CD20 PF04103.15 CDI77988.1 - 3.8 7.6 7.7 4.7 7.3 7.7 1.3 1 1 0 1 1 1 0 CD20-like family DDHD PF02862.17 CDI77988.1 - 4.8 7.3 10.5 5.4 7.1 10.5 1.1 1 0 0 1 1 1 0 DDHD domain Amnionless PF14828.6 CDI77988.1 - 5.4 5.7 18.6 5.6 5.7 18.6 1.0 1 0 0 1 1 1 0 Amnionless CLN3 PF02487.17 CDI77988.1 - 5.7 5.9 12.0 6.3 5.7 12.0 1.1 1 0 0 1 1 1 0 CLN3 protein DUF3492 PF11997.8 CDI77988.1 - 9 5.9 8.6 9.2 5.9 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) FAM60A PF15396.6 CDI77988.1 - 9.5 6.2 10.9 11 5.9 10.9 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF3675 PF12428.8 CDI77988.1 - 9.7 6.8 13.5 21 5.7 13.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3675) Spatacsin_C PF14649.6 CDI78009.1 - 1.5e-10 40.7 6.7 7.6e-05 22.0 6.2 2.6 2 1 0 2 2 2 2 Spatacsin C-terminus PDEase_I PF00233.19 CDI78024.1 - 1.4e-61 208.3 0.1 1.4e-61 208.3 0.1 2.1 3 0 0 3 3 3 1 3'5'-cyclic nucleotide phosphodiesterase DUF2722 PF10846.8 CDI78024.1 - 0.002 17.2 15.2 0.12 11.2 3.2 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF2722) RskA PF10099.9 CDI78024.1 - 0.0037 17.6 8.1 0.0037 17.6 8.1 3.6 3 1 1 4 4 4 1 Anti-sigma-K factor rskA HD PF01966.22 CDI78024.1 - 0.015 15.5 0.1 0.041 14.1 0.1 1.7 1 0 0 1 1 1 0 HD domain K_channel_TID PF07941.11 CDI78024.1 - 0.022 15.2 18.7 0.022 15.2 18.7 2.5 2 0 0 2 2 1 0 Potassium channel Kv1.4 tandem inactivation domain Myc_N PF01056.18 CDI78024.1 - 0.17 11.8 3.8 0.43 10.4 3.8 1.7 1 0 0 1 1 1 0 Myc amino-terminal region DUF2203 PF09969.9 CDI78024.1 - 0.44 11.3 6.9 0.58 10.9 0.2 3.3 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) Spt20 PF12090.8 CDI78024.1 - 0.52 9.9 25.1 0.31 10.6 4.5 2.5 2 0 0 2 2 2 0 Spt20 family DUF4834 PF16118.5 CDI78024.1 - 0.64 11.0 11.5 12 6.9 0.2 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) AIF_C PF14721.6 CDI78024.1 - 0.75 10.2 2.6 15 6.0 1.3 2.5 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Sin_N PF04801.13 CDI78024.1 - 2.3 7.3 11.8 2 7.6 2.6 2.4 2 0 0 2 2 2 0 Sin-like protein conserved region SUIM_assoc PF16619.5 CDI78024.1 - 3.7 7.7 28.2 8.4 6.5 8.5 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Prefoldin PF02996.17 CDI78029.1 - 2.4e-18 66.2 1.3 1.4e-17 63.7 1.3 1.9 1 1 0 1 1 1 1 Prefoldin subunit RecG_N PF17190.4 CDI78029.1 - 0.14 12.9 2.5 0.29 11.9 0.5 2.1 2 0 0 2 2 2 0 RecG N-terminal helical domain DUF3626 PF12294.8 CDI78033.1 - 4e-08 32.7 0.0 0.0022 17.1 0.0 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF3626) DUF572 PF04502.13 CDI78034.1 - 0.00071 19.3 5.3 0.00071 19.3 5.3 4.8 4 1 0 4 4 4 1 Family of unknown function (DUF572) SpoIIP PF07454.11 CDI78034.1 - 0.0017 17.8 9.6 0.0017 17.8 9.6 4.8 5 1 0 5 5 5 2 Stage II sporulation protein P (SpoIIP) DUF4050 PF13259.6 CDI78034.1 - 0.0021 18.4 0.0 0.0021 18.4 0.0 5.9 3 2 1 4 4 4 1 Protein of unknown function (DUF4050) Connexin PF00029.19 CDI78034.1 - 0.0022 17.8 3.8 0.0022 17.8 3.8 4.5 4 1 1 5 5 5 1 Connexin DUF4484 PF14831.6 CDI78034.1 - 0.0039 17.3 1.2 0.0039 17.3 1.2 5.5 5 1 1 6 6 6 1 Domain of unknown function (DUF4484) DUF4905 PF16248.5 CDI78034.1 - 0.028 14.3 0.3 0.21 11.5 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4905) DUF2722 PF10846.8 CDI78034.1 - 0.38 9.7 0.0 0.091 11.7 2.8 8.0 4 2 4 8 8 8 0 Protein of unknown function (DUF2722) CDC45 PF02724.14 CDI78034.1 - 0.9 7.8 42.2 0.0066 14.8 5.2 4.1 4 0 0 4 4 4 0 CDC45-like protein SID-1_RNA_chan PF13965.6 CDI78034.1 - 2.1 6.7 28.0 3 6.1 9.4 2.6 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 CDI78034.1 - 9.6 5.0 40.3 0.083 11.8 7.1 3.0 2 1 1 3 3 3 0 Ceramide synthase regulator VIR_N PF15912.5 CDI78037.1 - 0.019 14.6 12.4 0.026 14.1 12.4 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal RIFIN PF02009.16 CDI78037.1 - 0.12 12.3 10.5 0.16 11.9 10.5 1.1 1 0 0 1 1 1 0 Rifin PAT1 PF09770.9 CDI78037.1 - 0.62 8.3 48.3 0.74 8.0 48.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4820 PF16091.5 CDI78046.1 - 0.0066 15.8 3.4 0.01 15.2 3.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4820) V_ATPase_I PF01496.19 CDI78046.1 - 0.032 12.2 4.4 0.037 11.9 4.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TFIIA PF03153.13 CDI78046.1 - 0.032 14.2 34.4 0.052 13.6 34.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2151 PF10221.9 CDI78046.1 - 0.056 12.0 4.0 0.06 12.0 4.0 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Afi1 PF07792.12 CDI78046.1 - 0.11 13.0 8.4 0.21 12.0 8.4 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking D123 PF07065.14 CDI78046.1 - 0.15 11.2 5.0 0.23 10.6 5.0 1.4 1 0 0 1 1 1 0 D123 Neur_chan_memb PF02932.16 CDI78046.1 - 0.36 10.8 5.8 0.73 9.8 5.8 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI78046.1 - 0.66 8.7 6.9 0.71 8.6 6.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SID-1_RNA_chan PF13965.6 CDI78046.1 - 0.67 8.3 2.0 0.65 8.3 2.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 OATP PF03137.20 CDI78046.1 - 0.89 7.8 3.8 1.3 7.2 3.8 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CLN3 PF02487.17 CDI78046.1 - 1.6 7.7 7.6 2.3 7.2 7.6 1.3 1 0 0 1 1 1 0 CLN3 protein Connexin PF00029.19 CDI78046.1 - 2 8.1 4.9 2.9 7.6 4.9 1.3 1 0 0 1 1 1 0 Connexin FAM176 PF14851.6 CDI78046.1 - 2.6 7.7 9.4 4.8 6.8 9.4 1.5 1 0 0 1 1 1 0 FAM176 family SpoIIP PF07454.11 CDI78046.1 - 3.5 7.0 12.8 5.7 6.3 12.8 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) BBL5 PF07289.11 CDI78046.1 - 5.7 5.9 7.2 8.6 5.3 7.2 1.2 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein SUIM_assoc PF16619.5 CDI78054.1 - 0.0015 18.6 2.7 0.0015 18.6 2.7 9.1 7 2 2 9 9 9 2 Unstructured region C-term to UIM in Ataxin3 CBP_BcsG PF11658.8 CDI78062.1 - 0.00024 19.6 0.6 0.00024 19.6 0.6 4.7 2 2 1 4 4 4 1 Cellulose biosynthesis protein BcsG Trypan_PARP PF05887.11 CDI78062.1 - 1.6 8.7 43.0 0.061 13.3 9.0 3.2 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) ArsP_2 PF11449.8 CDI78068.1 - 0.033 13.4 0.6 0.033 13.4 0.6 2.7 1 1 1 2 2 2 0 Putative, 10TM heavy-metal exporter SID-1_RNA_chan PF13965.6 CDI78068.1 - 2 6.7 20.5 2.6 6.4 20.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Isy1 PF06246.12 CDI78068.1 - 3.4 7.2 35.1 4.8 6.7 35.1 1.2 1 0 0 1 1 1 0 Isy1-like splicing family RskA PF10099.9 CDI78077.1 - 1.1e-06 29.1 0.0 1.1e-06 29.1 0.0 6.0 1 1 4 5 5 5 2 Anti-sigma-K factor rskA FAM76 PF16046.5 CDI78078.1 - 0.0023 17.3 3.7 0.0023 17.3 3.7 1.8 2 0 0 2 2 2 1 FAM76 protein DUF1180 PF06679.12 CDI78078.1 - 0.0024 18.3 6.6 0.0024 18.3 6.6 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF1180) Spt20 PF12090.8 CDI78078.1 - 0.0034 17.1 20.3 0.0066 16.1 20.3 1.5 1 0 0 1 1 1 1 Spt20 family TRAP_alpha PF03896.16 CDI78078.1 - 0.025 13.8 0.4 0.041 13.1 0.4 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CPSF100_C PF13299.6 CDI78078.1 - 0.1 12.8 3.1 0.17 12.1 3.1 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal TFIIA PF03153.13 CDI78078.1 - 0.16 12.0 21.1 0.26 11.2 21.1 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tim54 PF11711.8 CDI78078.1 - 0.22 10.3 4.4 0.29 9.9 4.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CobT PF06213.12 CDI78078.1 - 0.58 9.5 10.2 0.79 9.1 10.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2126 PF09899.9 CDI78078.1 - 0.84 7.6 3.5 1 7.3 3.5 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Mcm10 PF09332.11 CDI78078.1 - 0.95 8.8 12.5 1.8 7.9 12.5 1.4 1 0 0 1 1 1 0 Mcm10 replication factor CCDC53 PF10152.9 CDI78078.1 - 1 9.8 9.9 1.6 9.2 9.9 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Coilin_N PF15862.5 CDI78078.1 - 1 9.2 13.8 2.8 7.7 13.8 1.7 1 0 0 1 1 1 0 Coilin N-terminus Sin_N PF04801.13 CDI78078.1 - 1.9 7.6 16.2 2.8 7.0 16.2 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region Med15 PF09606.10 CDI78078.1 - 3.2 6.3 21.7 4.2 5.9 21.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Band_3_cyto PF07565.13 CDI78078.1 - 5.8 6.6 11.9 0.29 10.9 6.3 1.7 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF3943 PF13084.6 CDI78090.1 - 0.13 12.1 0.2 29 4.6 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3943) RskA PF10099.9 CDI78106.1 - 0.0026 18.1 11.7 0.0026 18.1 11.7 2.4 1 1 0 2 2 2 1 Anti-sigma-K factor rskA Trp_oprn_chp PF09534.10 CDI78106.1 - 8.5 6.1 12.8 11 5.8 7.9 2.5 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) WTX PF09422.10 CDI78106.1 - 8.5 5.3 16.3 0.11 11.6 8.2 1.7 1 1 1 2 2 2 0 WTX protein RskA PF10099.9 CDI78107.1 - 9.7e-06 26.0 28.1 0.00039 20.8 5.7 10.0 4 2 4 8 8 8 3 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI78107.1 - 0.00089 18.3 5.5 0.00089 18.3 5.5 5.7 4 2 2 6 6 6 1 Protein of unknown function (DUF2722) TCP PF03634.13 CDI78108.1 - 0.019 15.6 12.8 0.019 15.6 12.8 3.3 1 1 2 3 3 3 0 TCP family transcription factor BUD22 PF09073.10 CDI78108.1 - 0.04 13.2 32.8 0.013 14.8 25.4 2.0 2 0 0 2 2 2 0 BUD22 Plasmodium_Vir PF05795.11 CDI78108.1 - 0.17 11.3 17.5 6.2 6.1 15.6 2.2 1 1 1 2 2 2 0 Plasmodium vivax Vir protein RskA PF10099.9 CDI78110.1 - 0.00023 21.5 4.9 0.00023 21.5 4.9 6.0 1 1 2 3 3 3 1 Anti-sigma-K factor rskA SRP9-21 PF05486.12 CDI78111.1 - 0.047 14.1 0.3 0.047 14.1 0.3 2.7 2 1 0 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) Apt1 PF10351.9 CDI78111.1 - 0.94 8.3 32.9 0.5 9.1 18.3 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain AAA_33 PF13671.6 CDI78118.1 - 0.0051 17.0 0.1 0.009 16.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain DUF2722 PF10846.8 CDI78120.1 - 0.005 15.8 0.7 0.005 15.8 0.7 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF2722) Adipogenin PF15202.6 CDI78121.1 - 0.035 14.1 2.4 0.4 10.7 1.5 2.3 2 0 0 2 2 2 0 Adipogenin DUF4834 PF16118.5 CDI78121.1 - 0.1 13.6 0.0 0.29 12.1 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Tmemb_9 PF05434.11 CDI78121.1 - 0.16 11.9 0.1 0.44 10.4 0.0 1.8 2 0 0 2 2 2 0 TMEM9 TRAP_alpha PF03896.16 CDI78121.1 - 0.17 11.1 1.8 0.38 9.9 0.3 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit CLN3 PF02487.17 CDI78121.1 - 0.18 10.8 2.1 0.29 10.2 0.1 1.9 2 0 0 2 2 2 0 CLN3 protein Endomucin PF07010.12 CDI78121.1 - 3.2 7.6 22.7 4.3 7.2 7.4 2.3 2 0 0 2 2 2 0 Endomucin SIT PF15330.6 CDI78121.1 - 4 7.9 9.3 0.69 10.4 4.8 2.2 2 1 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT UPF0565 PF10561.9 CDI78121.1 - 9.5 5.3 5.4 4.6 6.4 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 SUIM_assoc PF16619.5 CDI78143.1 - 0.0056 16.7 0.6 0.0056 16.7 0.6 4.2 4 0 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI78143.1 - 0.029 14.7 36.3 0.2 11.9 14.4 3.3 3 0 0 3 3 3 0 Anti-sigma-K factor rskA RXT2_N PF08595.11 CDI78143.1 - 0.2 11.7 12.7 0.13 12.3 0.5 3.3 3 0 0 3 3 3 0 RXT2-like, N-terminal Ribosomal_60s PF00428.19 CDI78143.1 - 0.25 11.9 0.1 0.25 11.9 0.1 6.0 5 1 0 5 5 5 0 60s Acidic ribosomal protein FHIPEP PF00771.20 CDI78143.1 - 2 6.8 5.3 7.5 4.9 1.6 2.3 2 0 0 2 2 2 0 FHIPEP family DUF3381 PF11861.8 CDI78143.1 - 4.3 7.1 16.5 6.8 6.5 3.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) DUF4834 PF16118.5 CDI78172.1 - 0.0012 19.8 8.7 0.29 12.1 2.1 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4834) TFIIA PF03153.13 CDI78172.1 - 0.0037 17.3 33.3 0.066 13.2 5.8 3.0 3 0 0 3 3 3 2 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI78172.1 - 0.042 12.6 7.9 0.17 10.6 2.4 2.3 2 0 0 2 2 2 0 Presenilin Neur_chan_memb PF02932.16 CDI78172.1 - 0.046 13.8 1.1 0.34 10.9 0.6 2.3 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CAF1 PF04857.20 CDI78172.1 - 0.075 12.2 0.2 1.4 8.0 0.0 1.7 1 1 1 2 2 1 0 CAF1 family ribonuclease PIP5K PF01504.18 CDI78172.1 - 0.12 11.5 2.4 0.062 12.5 0.2 1.6 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase CLN3 PF02487.17 CDI78172.1 - 0.3 10.1 10.2 1.3 8.0 9.0 2.2 2 1 0 2 2 2 0 CLN3 protein EIF4E-T PF10477.9 CDI78172.1 - 0.55 9.0 20.2 0.6 8.9 19.8 1.3 1 1 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DDHD PF02862.17 CDI78172.1 - 0.64 10.1 0.0 0.64 10.1 0.0 3.1 2 1 0 2 2 1 0 DDHD domain Rxt3 PF08642.10 CDI78172.1 - 1.4 9.7 5.5 2.3 9.0 0.4 2.9 3 0 0 3 3 3 0 Histone deacetylation protein Rxt3 DUF5320 PF17253.2 CDI78172.1 - 1.9 9.6 6.0 13 6.9 0.4 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5320) Connexin PF00029.19 CDI78172.1 - 1.9 8.2 6.4 8.2 6.1 1.9 2.9 3 0 0 3 3 3 0 Connexin Med15 PF09606.10 CDI78172.1 - 3.9 6.0 40.8 0.034 12.9 15.1 2.4 3 0 0 3 3 3 0 ARC105 or Med15 subunit of Mediator complex non-fungal PepSY_TM PF03929.16 CDI78172.1 - 4 7.0 11.2 10 5.7 0.4 3.4 3 0 0 3 3 3 0 PepSY-associated TM region CSG2 PF16965.5 CDI78172.1 - 4.8 6.0 6.5 5.3 5.9 0.0 2.7 3 0 0 3 3 3 0 Ceramide synthase regulator DUF2722 PF10846.8 CDI78172.1 - 5.1 5.9 38.5 0.24 10.3 5.3 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) SpoIIP PF07454.11 CDI78172.1 - 7.5 5.9 8.9 8.2 5.8 2.7 2.8 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) BUD22 PF09073.10 CDI78172.1 - 7.7 5.7 16.9 0.85 8.9 3.4 3.0 3 0 0 3 3 3 0 BUD22 Zn_peptidase PF04228.13 CDI78172.1 - 9.4 5.6 12.1 0.24 10.8 1.6 2.5 2 0 0 2 2 2 0 Putative neutral zinc metallopeptidase Activator_LAG-3 PF11498.8 CDI78261.1 - 8.4 5.2 62.7 3.3 6.6 3.7 3.4 3 0 0 3 3 3 0 Transcriptional activator LAG-3 Attachment_P66 PF11263.8 CDI78266.1 - 0.044 13.1 0.0 0.092 12.0 0.0 1.5 1 0 0 1 1 1 0 Borrelia burgdorferi attachment protein P66 DUF4079 PF13301.6 CDI78266.1 - 0.14 12.3 0.0 0.14 12.3 0.0 9.9 10 4 2 12 12 12 0 Protein of unknown function (DUF4079) N6_N4_Mtase PF01555.18 CDI78266.1 - 0.54 9.9 19.7 99 2.5 0.0 7.2 5 3 0 5 5 5 0 DNA methylase CemA PF03040.14 CDI78289.1 - 0.57 10.1 10.9 0.03 14.3 5.4 1.6 2 0 0 2 2 2 0 CemA family GET2 PF08690.10 CDI78290.1 - 0.34 10.6 20.3 0.37 10.4 20.3 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 Presenilin PF01080.17 CDI78290.1 - 0.42 9.3 22.3 0.46 9.2 22.3 1.1 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 CDI78290.1 - 0.47 8.7 34.9 0.46 8.7 34.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Exonuc_VII_L PF02601.15 CDI78290.1 - 0.54 9.8 20.6 0.64 9.5 20.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit RPN2_C PF18004.1 CDI78290.1 - 0.79 9.6 18.0 1.3 8.9 18.0 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Zip PF02535.22 CDI78290.1 - 2.3 7.3 8.3 2.7 7.1 8.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter LMBR1 PF04791.16 CDI78290.1 - 3.9 6.3 14.0 4.2 6.2 14.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA_23 PF13476.6 CDI78290.1 - 6.7 7.2 21.6 8.8 6.8 21.6 1.2 1 0 0 1 1 1 0 AAA domain eIF-3_zeta PF05091.12 CDI78290.1 - 8 5.3 24.0 9.3 5.1 24.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DDHD PF02862.17 CDI78290.1 - 10 6.2 20.2 14 5.7 20.2 1.4 1 0 0 1 1 1 0 DDHD domain PRP38_assoc PF12871.7 CDI78312.1 - 0.55 10.9 99.8 9.4 6.9 45.1 2.9 1 1 1 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Trypan_PARP PF05887.11 CDI78312.1 - 5.3 7.0 21.9 4.9 7.1 9.8 2.1 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) SR-25 PF10500.9 CDI78313.1 - 1.4 8.4 31.7 3.8 7.1 31.7 1.6 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Na_trans_assoc PF06512.13 CDI78313.1 - 8.8 6.5 25.0 10 6.3 25.0 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated CDC27 PF09507.10 CDI78318.1 - 0.0002 20.9 14.4 0.00025 20.6 14.4 1.2 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 PAT1 PF09770.9 CDI78318.1 - 0.012 13.9 18.4 0.013 13.8 18.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2052 PF09747.9 CDI78318.1 - 0.031 14.4 19.1 0.047 13.8 19.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RAB3GAP2_N PF14655.6 CDI78318.1 - 0.046 13.0 11.6 0.11 11.7 0.9 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PDGF_N PF04692.13 CDI78318.1 - 0.05 14.4 3.1 0.05 14.4 3.1 2.6 3 0 0 3 3 2 0 Platelet-derived growth factor, N terminal region MMR1 PF08505.10 CDI78318.1 - 0.054 13.8 14.4 0.089 13.1 14.4 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF572 PF04502.13 CDI78318.1 - 0.058 13.0 13.3 0.073 12.7 13.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Rgp1 PF08737.10 CDI78318.1 - 0.077 12.1 7.8 0.087 12.0 7.8 1.1 1 0 0 1 1 1 0 Rgp1 GET2 PF08690.10 CDI78318.1 - 0.092 12.4 11.2 0.12 12.1 11.2 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 PCEMA1 PF07418.11 CDI78318.1 - 0.095 12.2 8.8 0.13 11.8 8.8 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 SID-1_RNA_chan PF13965.6 CDI78318.1 - 0.1 11.0 1.4 0.11 10.9 1.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RR_TM4-6 PF06459.12 CDI78318.1 - 0.11 12.3 15.5 0.15 11.9 15.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PRP1_N PF06424.12 CDI78318.1 - 0.14 12.6 14.8 0.25 11.7 14.8 1.5 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Mit_ribos_Mrp51 PF11709.8 CDI78318.1 - 0.17 11.4 11.8 0.23 11.0 11.8 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit CDC45 PF02724.14 CDI78318.1 - 0.31 9.3 17.2 0.46 8.7 17.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI78318.1 - 0.37 9.5 19.0 0.53 9.0 19.0 1.2 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI78318.1 - 0.91 9.5 11.8 1.4 8.9 11.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Smg8_Smg9 PF10220.9 CDI78318.1 - 0.98 7.6 16.0 1.2 7.3 16.0 1.0 1 0 0 1 1 1 0 Smg8_Smg9 CDK5_activator PF03261.15 CDI78318.1 - 1 8.8 10.9 1.4 8.4 10.9 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Thg1C PF14413.6 CDI78318.1 - 1.5 9.0 10.8 1.9 8.6 0.5 2.2 2 0 0 2 2 2 0 Thg1 C terminal domain SLC12 PF03522.15 CDI78318.1 - 1.7 7.6 18.7 2.3 7.2 18.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Gti1_Pac2 PF09729.9 CDI78318.1 - 1.8 8.7 9.9 3.1 7.9 9.9 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family GREB1 PF15782.5 CDI78318.1 - 1.8 5.5 13.0 2.1 5.3 13.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Exonuc_VII_L PF02601.15 CDI78318.1 - 2.4 7.7 23.1 3.8 7.0 23.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sulfatase_C PF14707.6 CDI78318.1 - 2.7 8.7 10.9 1.5 9.6 8.7 1.6 2 0 0 2 2 1 0 C-terminal region of aryl-sulfatase Myc_N PF01056.18 CDI78318.1 - 2.9 7.7 18.3 0.092 12.6 12.2 1.5 2 0 0 2 2 2 0 Myc amino-terminal region Hid1 PF12722.7 CDI78318.1 - 3.3 5.7 17.1 4.1 5.4 17.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein VIR_N PF15912.5 CDI78318.1 - 3.6 7.1 9.6 5 6.6 9.6 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal RNase_H2_suC PF08615.11 CDI78318.1 - 4.1 7.6 9.4 2.6e+02 1.7 9.5 2.3 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) PA26 PF04636.13 CDI78318.1 - 5.1 5.9 13.6 7.1 5.4 13.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) FAM60A PF15396.6 CDI78318.1 - 5.6 6.9 13.3 9.8 6.1 13.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Asp-B-Hydro_N PF05279.11 CDI78318.1 - 9.7 6.2 18.7 15 5.6 18.7 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Baculo_PP31 PF05311.11 CDI78321.1 - 0.0073 15.8 0.1 0.012 15.1 0.1 1.3 1 0 0 1 1 1 1 Baculovirus 33KDa late protein (PP31) DDHD PF02862.17 CDI78321.1 - 0.015 15.5 1.1 0.032 14.4 1.1 1.5 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 CDI78321.1 - 0.018 15.1 0.4 0.025 14.7 0.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EOS1 PF12326.8 CDI78321.1 - 0.075 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 N-glycosylation protein Serinc PF03348.15 CDI78321.1 - 0.14 11.1 0.1 0.19 10.7 0.1 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) CCDC53 PF10152.9 CDI78321.1 - 0.33 11.4 18.2 0.03 14.7 4.0 3.2 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex Presenilin PF01080.17 CDI78321.1 - 0.4 9.4 11.2 0.64 8.7 11.2 1.2 1 0 0 1 1 1 0 Presenilin Pex26 PF07163.12 CDI78321.1 - 0.88 8.8 9.2 1.8 7.8 9.2 1.5 1 0 0 1 1 1 0 Pex26 protein CTU2 PF10288.9 CDI78321.1 - 1.4 9.2 14.4 3 8.1 14.4 1.5 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Connexin PF00029.19 CDI78321.1 - 1.7 8.4 9.0 2.4 7.8 9.0 1.2 1 0 0 1 1 1 0 Connexin CPSF100_C PF13299.6 CDI78321.1 - 2.9 8.0 10.8 2.4 8.3 7.6 2.3 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Tim54 PF11711.8 CDI78321.1 - 4.7 5.9 10.1 10 4.8 10.1 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 CDI78321.1 - 7.6 6.3 11.9 13 5.5 11.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SR-25 PF10500.9 CDI78327.1 - 9e-05 22.2 6.5 9e-05 22.2 6.5 4.7 5 0 0 5 5 5 2 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI78327.1 - 0.017 15.4 15.0 0.017 15.4 15.0 6.9 1 1 5 6 6 6 0 Anti-sigma-K factor rskA Shadoo PF14999.6 CDI78327.1 - 0.26 11.4 21.4 1.1 9.3 0.7 3.4 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective RskA PF10099.9 CDI78329.1 - 0.0024 18.2 16.4 0.0031 17.8 16.4 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA TERB2 PF15101.6 CDI78329.1 - 0.074 13.1 11.8 0.075 13.1 11.8 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 FHIPEP PF00771.20 CDI78329.1 - 0.15 10.5 4.9 0.16 10.4 4.9 1.0 1 0 0 1 1 1 0 FHIPEP family eIF-3_zeta PF05091.12 CDI78329.1 - 0.21 10.5 12.8 0.2 10.6 12.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Activator_LAG-3 PF11498.8 CDI78329.1 - 0.22 10.4 30.7 0.21 10.6 30.7 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Presenilin PF01080.17 CDI78329.1 - 0.3 9.8 9.5 0.28 9.9 9.5 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI78329.1 - 0.51 10.4 5.8 0.47 10.5 5.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Connexin PF00029.19 CDI78329.1 - 0.56 9.9 5.6 0.52 10.0 5.6 1.1 1 0 0 1 1 1 0 Connexin NEMP PF10225.9 CDI78329.1 - 0.61 9.7 2.1 0.64 9.7 2.1 1.0 1 0 0 1 1 1 0 NEMP family EIIBC-GUT_N PF03612.14 CDI78329.1 - 0.62 9.8 7.9 0.59 9.9 7.9 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4834 PF16118.5 CDI78329.1 - 0.63 11.0 12.4 0.78 10.7 12.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EOS1 PF12326.8 CDI78329.1 - 0.81 9.6 3.1 0.77 9.7 3.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein Suf PF05843.14 CDI78329.1 - 0.91 9.4 13.7 0.84 9.6 13.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF1980 PF09323.10 CDI78329.1 - 0.97 9.3 5.3 0.96 9.3 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) PBP_sp32 PF07222.12 CDI78329.1 - 1 8.7 11.8 1.1 8.7 11.8 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 TFIIA PF03153.13 CDI78329.1 - 1.1 9.2 32.9 1.2 9.1 32.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ctr PF04145.15 CDI78329.1 - 1.6 9.3 4.5 1.7 9.2 4.5 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Spt20 PF12090.8 CDI78329.1 - 2.2 7.8 35.9 2.5 7.7 35.9 1.1 1 0 0 1 1 1 0 Spt20 family Zip PF02535.22 CDI78329.1 - 2.2 7.4 3.7 2 7.5 3.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Folate_carrier PF01770.18 CDI78329.1 - 2.4 6.8 5.0 2.3 6.8 5.0 1.1 1 0 0 1 1 1 0 Reduced folate carrier CLN3 PF02487.17 CDI78329.1 - 2.9 6.8 5.9 2.7 6.9 5.9 1.1 1 0 0 1 1 1 0 CLN3 protein R_equi_Vir PF05526.11 CDI78329.1 - 5 6.9 7.9 5.8 6.7 7.9 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein OATP PF03137.20 CDI78329.1 - 7.2 4.8 6.2 6.7 4.9 6.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Serinc PF03348.15 CDI78329.1 - 8.4 5.2 5.8 8 5.3 5.8 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Usp PF00582.26 CDI78329.1 - 8.4 6.9 8.8 10 6.6 8.8 1.1 1 0 0 1 1 1 0 Universal stress protein family Auto_anti-p27 PF06677.12 CDI78332.1 - 1.5e-17 63.5 1.4 2.6e-17 62.7 1.4 1.4 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Spt20 PF12090.8 CDI78332.1 - 0.017 14.7 25.2 0.017 14.7 25.2 3.1 2 1 1 3 3 3 0 Spt20 family CCDC106 PF15794.5 CDI78332.1 - 0.024 14.4 24.6 0.21 11.3 11.1 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 ATAD4 PF15321.6 CDI78332.1 - 0.033 15.5 2.3 0.033 15.5 2.3 3.2 2 1 1 3 3 3 0 ATPase family AAA domain containing 4 SARAF PF06682.12 CDI78332.1 - 0.043 13.5 22.1 0.074 12.7 22.1 1.3 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Lar_restr_allev PF14354.6 CDI78332.1 - 1.6 9.2 4.8 5 7.6 4.8 2.1 1 1 0 1 1 1 0 Restriction alleviation protein Lar Suf PF05843.14 CDI78332.1 - 1.6 8.6 33.3 0.75 9.7 15.3 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) THOC2_N PF16134.5 CDI78332.1 - 2.6 6.5 22.0 0.016 13.8 7.4 2.1 2 0 0 2 2 2 0 THO complex subunit 2 N-terminus cwf18 PF08315.12 CDI78332.1 - 3.8 8.2 27.6 8.1 7.1 2.7 2.4 2 0 0 2 2 2 0 cwf18 pre-mRNA splicing factor SIMPL PF04402.14 CDI78337.1 - 0.17 12.3 3.5 0.36 11.3 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF541) Oxysterol_BP PF01237.18 CDI78342.1 - 3.2e-20 72.3 0.0 3e-17 62.5 0.0 6.0 3 2 2 6 6 6 3 Oxysterol-binding protein PH PF00169.29 CDI78342.1 - 4.5e-12 46.4 0.3 1.5e-11 44.8 0.3 1.9 1 0 0 1 1 1 1 PH domain SUIM_assoc PF16619.5 CDI78342.1 - 0.00053 20.0 0.0 0.00053 20.0 0.0 17.1 7 4 3 10 10 10 2 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 CDI78342.1 - 0.0018 17.3 11.0 0.0018 17.3 11.0 10.2 5 3 4 9 9 9 2 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI78342.1 - 0.0068 16.4 48.9 0.0068 16.4 48.9 7.4 3 2 3 6 6 6 1 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CDI78342.1 - 0.067 13.6 0.2 0.067 13.6 0.2 8.9 4 3 2 6 6 6 0 Enhancer of polycomb-like Ribosomal_60s PF00428.19 CDI78344.1 - 0.00019 22.0 11.4 0.00019 22.0 11.4 2.7 2 0 0 2 2 2 1 60s Acidic ribosomal protein TFIIA PF03153.13 CDI78344.1 - 0.00023 21.3 65.3 0.00074 19.6 65.3 1.8 1 1 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Band_3_cyto PF07565.13 CDI78344.1 - 0.0044 16.9 24.2 0.0044 16.9 24.2 2.6 3 0 0 3 3 3 1 Band 3 cytoplasmic domain RNA_pol_Rpc4 PF05132.14 CDI78344.1 - 0.11 13.0 24.6 0.055 13.9 8.7 3.1 3 0 0 3 3 3 0 RNA polymerase III RPC4 Presenilin PF01080.17 CDI78344.1 - 0.14 10.9 35.6 0.027 13.3 24.9 2.9 3 0 0 3 3 3 0 Presenilin PTPRCAP PF15713.5 CDI78344.1 - 2.2 8.5 35.8 0.34 11.2 22.1 2.5 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated RR_TM4-6 PF06459.12 CDI78344.1 - 2.3 8.0 32.9 0.47 10.2 21.0 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RAP1 PF07218.11 CDI78344.1 - 2.3 6.4 9.1 0.12 10.6 1.5 2.1 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) DAG_kinase_N PF14513.6 CDI78344.1 - 4.8 7.4 27.1 3.5 7.8 18.5 3.1 3 0 0 3 3 3 0 Diacylglycerol kinase N-terminus Tim54 PF11711.8 CDI78344.1 - 5 5.8 24.5 0.23 10.2 12.3 2.3 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Peptidase_S46 PF10459.9 CDI78344.1 - 5.6 5.5 28.5 7.9 5.0 28.5 1.1 1 0 0 1 1 1 0 Peptidase S46 Neur_chan_memb PF02932.16 CDI78344.1 - 6.9 6.7 27.8 0.92 9.5 20.8 2.6 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region PPP4R2 PF09184.11 CDI78428.1 - 0.43 10.1 30.3 0.49 9.9 30.3 1.0 1 0 0 1 1 1 0 PPP4R2 TFIIA PF03153.13 CDI78428.1 - 0.53 10.2 31.8 0.62 10.0 31.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DivIC PF04977.15 CDI78428.1 - 3.2 7.6 11.4 4.6 7.1 11.4 1.2 1 0 0 1 1 1 0 Septum formation initiator GREB1 PF15782.5 CDI78475.1 - 0.0046 14.2 51.9 0.0053 14.0 51.9 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer Dicty_REP PF05086.12 CDI78475.1 - 0.025 12.6 30.2 0.029 12.4 30.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PAT1 PF09770.9 CDI78475.1 - 0.32 9.2 76.9 0.38 9.0 76.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LAP1C PF05609.12 CDI78475.1 - 1.2 8.1 50.5 1.5 7.9 50.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF4045 PF13254.6 CDI78475.1 - 2 8.0 45.7 3.1 7.3 45.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF572 PF04502.13 CDI78475.1 - 2.6 7.6 46.7 3.7 7.1 46.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Utp14 PF04615.13 CDI78475.1 - 3 6.3 48.7 3.4 6.1 48.7 1.0 1 0 0 1 1 1 0 Utp14 protein PCM1_C PF15717.5 CDI78475.1 - 3 6.4 49.5 3.7 6.1 49.5 1.1 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Dapper PF15268.6 CDI78475.1 - 3.4 6.4 60.0 4 6.2 60.0 1.1 1 0 0 1 1 1 0 Dapper Caldesmon PF02029.15 CDI78475.1 - 7 5.3 52.1 8.9 4.9 52.1 1.1 1 0 0 1 1 1 0 Caldesmon CDC45 PF02724.14 CDI78475.1 - 7.6 4.7 51.3 9.9 4.3 51.3 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI78534.1 - 0.22 10.5 36.5 0.23 10.4 36.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF572 PF04502.13 CDI78534.1 - 0.5 9.9 35.7 0.71 9.4 35.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Nop53 PF07767.11 CDI78534.1 - 0.73 9.2 47.7 1 8.6 47.7 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PPP4R2 PF09184.11 CDI78534.1 - 0.74 9.4 25.1 0.78 9.3 25.1 1.1 1 0 0 1 1 1 0 PPP4R2 SOBP PF15279.6 CDI78534.1 - 0.94 10.0 36.4 1.2 9.7 36.4 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Raftlin PF15250.6 CDI78534.1 - 1.2 7.8 29.5 1.2 7.8 29.5 1.2 1 0 0 1 1 1 0 Raftlin Hamartin PF04388.12 CDI78534.1 - 1.7 7.2 35.5 1.7 7.2 35.5 1.2 1 0 0 1 1 1 0 Hamartin protein Hid1 PF12722.7 CDI78534.1 - 2.4 6.2 37.1 2.5 6.1 37.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC27 PF09507.10 CDI78534.1 - 2.5 7.4 49.3 3.1 7.1 49.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 GAGA_bind PF06217.12 CDI78534.1 - 4.2 7.6 31.6 6.2 7.0 31.6 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family PAT1 PF09770.9 CDI78534.1 - 4.5 5.4 58.8 5.5 5.1 58.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 VIR_N PF15912.5 CDI78534.1 - 5.3 6.6 26.0 7.5 6.1 26.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal CDC45 PF02724.14 CDI78534.1 - 9.3 4.4 35.8 11 4.1 35.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Otopetrin PF03189.13 CDI78541.1 - 0.0012 17.8 2.9 0.0012 17.8 2.9 5.9 1 1 2 3 3 3 1 Otopetrin Suf PF05843.14 CDI78545.1 - 0.0078 16.2 12.9 0.0078 16.2 12.9 8.2 4 1 2 6 6 6 2 Suppressor of forked protein (Suf) tRNA-synt_1 PF00133.22 CDI78555.1 - 6.5e-63 212.9 0.0 1.8e-25 89.3 0.0 5.7 5 2 0 5 5 5 5 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDI78555.1 - 2.8e-18 66.3 0.0 7.4e-18 65.0 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDI78555.1 - 2.5e-09 36.4 0.0 7.7e-07 28.2 0.0 3.3 3 0 0 3 3 3 1 tRNA synthetases class I (M) DUF2012 PF09430.10 CDI78557.1 - 5.6e-10 39.4 0.0 7.6e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) Anophelin PF10731.9 CDI78557.1 - 0.14 12.0 0.2 0.25 11.2 0.2 1.4 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito OTU PF02338.19 CDI78559.1 - 3.2e-10 40.6 0.0 1.3e-09 38.6 0.0 2.0 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 CDI78559.1 - 0.00052 19.5 0.1 0.027 13.9 0.1 2.3 1 1 1 2 2 2 2 Peptidase C65 Otubain VWA PF00092.28 CDI78561.1 - 2.2e-31 109.5 0.0 3e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain TSP_1 PF00090.19 CDI78561.1 - 5.2e-26 90.6 66.1 6.4e-09 35.9 2.9 7.1 6 1 0 6 6 6 6 Thrombospondin type 1 domain VWA_2 PF13519.6 CDI78561.1 - 3.8e-13 50.0 0.0 7.7e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain CLN3 PF02487.17 CDI78571.1 - 0.0067 15.5 3.7 0.0068 15.5 3.7 1.0 1 0 0 1 1 1 1 CLN3 protein TRAP_alpha PF03896.16 CDI78571.1 - 0.013 14.8 15.6 0.014 14.7 15.6 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Kei1 PF08552.11 CDI78571.1 - 0.023 14.6 0.6 0.026 14.4 0.6 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 RNA_pol_Rpc4 PF05132.14 CDI78571.1 - 0.036 14.5 8.2 0.039 14.4 8.2 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Zip PF02535.22 CDI78571.1 - 0.083 12.1 7.4 0.086 12.0 7.4 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Connexin PF00029.19 CDI78571.1 - 0.1 12.4 11.1 0.11 12.2 11.1 1.1 1 0 0 1 1 1 0 Connexin DUF913 PF06025.12 CDI78571.1 - 0.13 11.2 9.3 0.14 11.1 9.3 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Orf78 PF06024.12 CDI78571.1 - 0.14 12.5 0.7 0.18 12.1 0.7 1.3 1 1 0 1 1 1 0 Orf78 (ac78) FYDLN_acid PF09538.10 CDI78571.1 - 0.21 12.3 18.8 0.25 12.1 18.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DNA_pol_phi PF04931.13 CDI78571.1 - 0.24 9.5 34.9 0.27 9.3 34.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi DUF4366 PF14283.6 CDI78571.1 - 0.27 11.2 11.5 0.32 11.0 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) FGF-BP1 PF06473.12 CDI78571.1 - 0.29 11.0 13.2 0.33 10.8 13.2 1.0 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) XRN_N PF03159.18 CDI78571.1 - 0.29 10.5 6.8 0.41 10.0 6.8 1.3 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus MIF4G_like_2 PF09090.11 CDI78571.1 - 0.37 10.2 15.5 0.4 10.1 15.5 1.0 1 0 0 1 1 1 0 MIF4G like CTU2 PF10288.9 CDI78571.1 - 0.42 10.9 7.7 0.58 10.4 7.7 1.3 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 CPSF100_C PF13299.6 CDI78571.1 - 0.42 10.8 13.2 0.51 10.5 13.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RPN2_C PF18004.1 CDI78571.1 - 0.48 10.3 25.7 0.52 10.2 25.7 1.0 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain FAM60A PF15396.6 CDI78571.1 - 0.78 9.7 6.8 0.81 9.7 6.8 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Mpp10 PF04006.12 CDI78571.1 - 0.79 8.1 31.7 0.94 7.8 31.7 1.0 1 0 0 1 1 1 0 Mpp10 protein V_ATPase_I PF01496.19 CDI78571.1 - 0.84 7.5 15.3 0.9 7.4 15.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 CDI78571.1 - 0.91 8.2 13.3 1.1 8.0 13.3 1.0 1 0 0 1 1 1 0 Presenilin Pox_Ag35 PF03286.14 CDI78571.1 - 1 9.1 23.0 1.4 8.7 23.0 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Prothymosin PF03247.14 CDI78571.1 - 1 9.8 46.1 1.4 9.4 46.1 1.2 1 0 0 1 1 1 0 Prothymosin/parathymosin family BUD22 PF09073.10 CDI78571.1 - 1 8.6 26.4 1.2 8.4 26.4 1.0 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 CDI78571.1 - 1 7.5 31.1 1.2 7.3 31.1 1.0 1 0 0 1 1 1 0 Nop14-like family Folate_carrier PF01770.18 CDI78571.1 - 1.1 8.0 6.6 1.1 7.9 6.6 1.1 1 0 0 1 1 1 0 Reduced folate carrier ORC_WH_C PF18137.1 CDI78571.1 - 1.1 9.3 17.5 1.6 8.8 17.5 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal PIP5K PF01504.18 CDI78571.1 - 1.2 8.3 6.2 1.2 8.3 6.2 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2457 PF10446.9 CDI78571.1 - 1.2 8.1 36.7 1.4 8.0 36.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF3408 PF11888.8 CDI78571.1 - 1.3 9.2 18.6 1.5 8.9 18.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) OATP PF03137.20 CDI78571.1 - 1.5 7.0 5.1 1.6 6.9 5.1 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Nucleoside_tran PF01733.18 CDI78571.1 - 1.6 8.0 6.8 1.8 7.9 6.8 1.2 1 0 0 1 1 1 0 Nucleoside transporter EIIBC-GUT_N PF03612.14 CDI78571.1 - 1.9 8.2 10.1 2.1 8.0 10.1 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Afi1 PF07792.12 CDI78571.1 - 2 8.9 14.9 2.5 8.6 14.9 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MCM_bind PF09739.9 CDI78571.1 - 2.1 6.7 14.0 2.2 6.6 14.0 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Rtf2 PF04641.12 CDI78571.1 - 2.2 7.6 12.6 2.6 7.4 12.6 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger RR_TM4-6 PF06459.12 CDI78571.1 - 2.2 8.0 23.6 2.4 7.9 23.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.8 CDI78571.1 - 2.4 6.9 19.4 3.1 6.5 19.4 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CSRNP_N PF16019.5 CDI78571.1 - 2.5 8.0 11.4 2.6 7.9 11.4 1.0 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus CSG2 PF16965.5 CDI78571.1 - 2.5 7.0 4.5 2.5 6.9 4.5 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4471 PF14740.6 CDI78571.1 - 2.9 7.0 10.3 3.4 6.8 10.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) TFB6 PF17110.5 CDI78571.1 - 3.1 7.5 14.8 3.6 7.3 14.8 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Vfa1 PF08432.10 CDI78571.1 - 3.3 8.0 19.6 3.5 7.9 19.6 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 THOC2_N PF16134.5 CDI78571.1 - 3.5 6.1 10.0 3.7 6.1 10.0 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus SpoIIP PF07454.11 CDI78571.1 - 3.5 7.0 17.0 3.7 6.9 17.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF5523 PF17661.1 CDI78571.1 - 4.1 7.0 28.7 5.1 6.7 28.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Slu7 PF11708.8 CDI78571.1 - 4.2 7.0 20.0 4.6 6.9 20.0 1.0 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor DDRGK PF09756.9 CDI78571.1 - 4.3 6.9 35.2 5 6.7 35.2 1.1 1 0 0 1 1 1 0 DDRGK domain RAB3GAP2_C PF14656.6 CDI78571.1 - 4.4 5.4 12.0 4.6 5.3 12.0 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus Serinc PF03348.15 CDI78571.1 - 4.6 6.1 8.5 5 5.9 8.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4746 PF15928.5 CDI78571.1 - 4.8 6.5 29.2 5.7 6.3 29.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Sigma70_ner PF04546.13 CDI78571.1 - 5.4 6.9 24.5 6 6.7 24.5 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2428 PF10350.9 CDI78571.1 - 5.5 6.2 9.5 6.4 6.0 9.5 1.1 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) Sec62 PF03839.16 CDI78571.1 - 5.6 6.4 10.9 6.4 6.2 10.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 MDM31_MDM32 PF08118.11 CDI78571.1 - 5.6 5.5 7.6 6.1 5.4 7.6 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF2828 PF11443.8 CDI78571.1 - 5.7 4.9 11.5 6 4.8 11.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF3306 PF11748.8 CDI78571.1 - 6 7.8 19.5 7.4 7.5 19.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Cwf_Cwc_15 PF04889.12 CDI78571.1 - 6.5 6.4 24.1 8 6.1 24.1 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Gti1_Pac2 PF09729.9 CDI78571.1 - 6.8 6.7 7.9 7.7 6.6 7.9 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family SDA1 PF05285.12 CDI78571.1 - 6.9 6.0 32.2 7.9 5.8 32.2 1.1 1 0 0 1 1 1 0 SDA1 DUF3391 PF11871.8 CDI78571.1 - 7.1 7.2 15.4 7.9 7.0 15.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) DDHD PF02862.17 CDI78571.1 - 7.5 6.6 8.3 8.2 6.5 8.3 1.1 1 0 0 1 1 1 0 DDHD domain NPR3 PF03666.13 CDI78571.1 - 7.8 5.2 17.0 9.1 5.0 17.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FancD2 PF14631.6 CDI78571.1 - 7.9 3.7 14.8 9.4 3.5 14.8 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease RP-C_C PF11800.8 CDI78571.1 - 8.4 6.4 11.0 9 6.3 11.0 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region AIF_C PF14721.6 CDI78571.1 - 9 6.7 11.2 11 6.3 11.2 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DARPP-32 PF05395.12 CDI78571.1 - 9.6 6.4 24.6 14 5.9 24.6 1.3 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 SID-1_RNA_chan PF13965.6 CDI78571.1 - 9.9 4.4 8.4 10 4.4 8.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TetR_C_12 PF16914.5 CDI78580.1 - 0.043 13.9 0.1 14 5.9 0.0 2.4 2 0 0 2 2 2 0 Bacterial transcriptional repressor C-terminal DUF4834 PF16118.5 CDI78588.1 - 4.6e-05 24.3 5.2 6.6e-05 23.8 5.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) CDC45 PF02724.14 CDI78588.1 - 0.00088 17.7 0.6 0.00088 17.7 0.6 1.0 1 0 0 1 1 1 1 CDC45-like protein Serinc PF03348.15 CDI78588.1 - 0.00097 18.2 1.6 0.001 18.1 1.6 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) CCDC53 PF10152.9 CDI78588.1 - 0.001 19.5 4.5 0.001 19.5 4.5 1.1 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex Presenilin PF01080.17 CDI78588.1 - 0.0011 17.8 5.6 0.0011 17.8 5.6 1.2 1 0 0 1 1 1 1 Presenilin CPSF100_C PF13299.6 CDI78588.1 - 0.0013 19.0 2.4 0.0013 19.0 2.4 1.1 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 CDI78588.1 - 0.0015 18.3 0.9 0.0015 18.3 0.9 1.2 1 0 0 1 1 1 1 Connexin DUF913 PF06025.12 CDI78588.1 - 0.0037 16.3 0.9 0.0038 16.3 0.9 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Folate_carrier PF01770.18 CDI78588.1 - 0.0043 15.9 1.0 0.0045 15.8 1.0 1.1 1 0 0 1 1 1 1 Reduced folate carrier DUF1980 PF09323.10 CDI78588.1 - 0.006 16.5 4.1 0.0071 16.3 4.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1980) eIF-3_zeta PF05091.12 CDI78588.1 - 0.0074 15.3 12.4 0.0074 15.3 12.4 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) HemX PF04375.14 CDI78588.1 - 0.0081 15.5 18.0 0.0079 15.5 18.0 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase PPL5 PF18168.1 CDI78588.1 - 0.0083 15.5 1.2 0.0083 15.5 1.2 1.1 1 0 0 1 1 1 1 Prim-pol family 5 SID-1_RNA_chan PF13965.6 CDI78588.1 - 0.0093 14.4 0.7 0.011 14.2 0.7 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 CLN3 PF02487.17 CDI78588.1 - 0.011 14.8 3.1 0.011 14.8 3.1 1.1 1 0 0 1 1 1 0 CLN3 protein DDHD PF02862.17 CDI78588.1 - 0.011 15.9 6.5 0.012 15.8 6.5 1.1 1 0 0 1 1 1 0 DDHD domain Kei1 PF08552.11 CDI78588.1 - 0.011 15.6 2.2 0.011 15.6 2.2 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Peroxin-13_N PF04088.13 CDI78588.1 - 0.013 15.8 2.1 0.013 15.7 2.1 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region G0-G1_switch_2 PF15103.6 CDI78588.1 - 0.013 15.9 2.1 0.014 15.8 2.1 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 FHIPEP PF00771.20 CDI78588.1 - 0.014 13.9 2.6 0.013 14.0 2.6 1.1 1 0 0 1 1 1 0 FHIPEP family EIIBC-GUT_N PF03612.14 CDI78588.1 - 0.016 15.0 7.2 0.018 14.8 7.2 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Peptidase_U57 PF05582.12 CDI78588.1 - 0.017 14.4 2.4 0.017 14.4 2.4 1.1 1 0 0 1 1 1 0 YabG peptidase U57 TFIIA PF03153.13 CDI78588.1 - 0.02 14.9 31.3 0.021 14.8 31.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit YABBY PF04690.13 CDI78588.1 - 0.02 15.4 2.4 0.021 15.4 2.4 1.2 1 0 0 1 1 1 0 YABBY protein U1snRNP70_N PF12220.8 CDI78588.1 - 0.03 15.0 8.2 0.045 14.4 8.2 1.2 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal CSG2 PF16965.5 CDI78588.1 - 0.04 12.9 1.9 0.041 12.8 1.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Ctr PF04145.15 CDI78588.1 - 0.044 14.4 1.3 0.044 14.4 1.3 1.2 1 0 0 1 1 1 0 Ctr copper transporter family DcuA_DcuB PF03605.14 CDI78588.1 - 0.054 12.4 0.5 0.066 12.1 0.5 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Pet20 PF08692.10 CDI78588.1 - 0.071 13.8 1.9 0.096 13.4 1.9 1.2 1 0 0 1 1 1 0 Mitochondrial protein Pet20 DUF2722 PF10846.8 CDI78588.1 - 0.076 12.0 33.5 0.095 11.6 33.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI78588.1 - 0.079 13.6 20.8 0.1 13.3 20.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SpoIIP PF07454.11 CDI78588.1 - 0.082 12.4 11.5 0.091 12.2 11.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Pex26 PF07163.12 CDI78588.1 - 0.089 12.1 8.4 0.099 11.9 8.4 1.1 1 0 0 1 1 1 0 Pex26 protein Eapp_C PF10238.9 CDI78588.1 - 0.1 12.7 10.3 0.12 12.4 10.3 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein PRC2_HTH_1 PF18118.1 CDI78588.1 - 0.11 13.3 7.2 0.14 13.0 7.2 1.1 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain PIP5K PF01504.18 CDI78588.1 - 0.11 11.7 7.0 0.12 11.6 7.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Baculo_PP31 PF05311.11 CDI78588.1 - 0.11 11.9 8.9 0.13 11.7 8.9 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Nucleoside_tran PF01733.18 CDI78588.1 - 0.13 11.7 0.5 0.13 11.6 0.5 1.2 1 0 0 1 1 1 0 Nucleoside transporter AAA_23 PF13476.6 CDI78588.1 - 0.14 12.6 13.0 0.16 12.5 13.0 1.1 1 0 0 1 1 1 0 AAA domain Orf78 PF06024.12 CDI78588.1 - 0.16 12.3 5.9 0.26 11.6 5.9 1.3 1 0 0 1 1 1 0 Orf78 (ac78) DUF2126 PF09899.9 CDI78588.1 - 0.17 9.9 4.7 0.18 9.9 4.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) RED_N PF07808.13 CDI78588.1 - 0.18 11.4 13.3 0.21 11.2 13.3 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF2828 PF11443.8 CDI78588.1 - 0.18 9.8 7.8 0.21 9.6 7.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Suf PF05843.14 CDI78588.1 - 0.19 11.7 16.6 0.22 11.5 16.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ureide_permease PF07168.11 CDI78588.1 - 0.21 10.3 2.6 0.26 10.0 2.6 1.1 1 0 0 1 1 1 0 Ureide permease TFB6 PF17110.5 CDI78588.1 - 0.23 11.2 4.8 0.27 11.0 4.8 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF3464 PF11947.8 CDI78588.1 - 0.23 11.2 12.6 0.37 10.5 12.6 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Spt20 PF12090.8 CDI78588.1 - 0.29 10.7 43.0 0.37 10.4 43.0 1.1 1 0 0 1 1 1 0 Spt20 family V_ATPase_I PF01496.19 CDI78588.1 - 0.31 8.9 10.4 0.34 8.8 10.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tim54 PF11711.8 CDI78588.1 - 0.35 9.6 9.7 0.4 9.4 9.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FAM60A PF15396.6 CDI78588.1 - 0.36 10.8 7.2 0.41 10.6 7.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Rxt3 PF08642.10 CDI78588.1 - 0.45 11.3 6.5 0.58 10.9 6.5 1.1 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Claudin_2 PF13903.6 CDI78588.1 - 0.5 10.1 4.2 0.69 9.6 4.1 1.4 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Coilin_N PF15862.5 CDI78588.1 - 0.5 10.2 13.4 0.67 9.8 13.4 1.2 1 0 0 1 1 1 0 Coilin N-terminus TERB2 PF15101.6 CDI78588.1 - 0.56 10.2 18.9 0.68 10.0 18.9 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF3675 PF12428.8 CDI78588.1 - 0.62 10.6 2.7 0.85 10.2 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) DUF702 PF05142.12 CDI78588.1 - 0.64 10.5 12.4 0.9 10.0 12.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF702) RR_TM4-6 PF06459.12 CDI78588.1 - 0.71 9.6 11.7 0.82 9.4 11.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Med15 PF09606.10 CDI78588.1 - 0.75 8.4 31.6 0.9 8.1 31.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Band_3_cyto PF07565.13 CDI78588.1 - 0.76 9.5 11.5 0.99 9.1 11.5 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4175 PF13779.6 CDI78588.1 - 0.79 7.6 31.2 0.92 7.3 31.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) NARP1 PF12569.8 CDI78588.1 - 0.91 8.4 11.5 1.1 8.1 11.5 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 OATP PF03137.20 CDI78588.1 - 0.91 7.7 6.5 1 7.5 6.5 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family PAT1 PF09770.9 CDI78588.1 - 0.92 7.7 21.0 1 7.5 21.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MMR1 PF08505.10 CDI78588.1 - 1.1 9.5 15.8 1.2 9.4 15.8 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein API5 PF05918.11 CDI78588.1 - 1.1 8.0 14.1 1.3 7.8 14.1 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) RskA PF10099.9 CDI78588.1 - 1.1 9.5 13.2 2.5 8.4 13.2 1.5 1 1 0 1 1 1 0 Anti-sigma-K factor rskA UPF0560 PF10577.9 CDI78588.1 - 1.1 7.6 19.3 1.2 7.5 19.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 MMU163 PF17119.5 CDI78588.1 - 1.2 8.3 6.6 1.4 8.1 6.6 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis TMEM51 PF15345.6 CDI78588.1 - 1.2 8.9 17.0 1.6 8.6 17.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Zip PF02535.22 CDI78588.1 - 1.3 8.2 4.0 1.6 7.9 4.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DDRGK PF09756.9 CDI78588.1 - 1.3 8.6 18.0 1.6 8.2 18.0 1.1 1 0 0 1 1 1 0 DDRGK domain DUF3408 PF11888.8 CDI78588.1 - 1.3 9.1 13.3 1.7 8.8 13.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Het-C PF07217.11 CDI78588.1 - 1.3 7.4 7.8 1.4 7.3 7.8 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C TRM13 PF05206.14 CDI78588.1 - 1.4 8.4 10.5 1.8 8.1 10.5 1.1 1 0 0 1 1 1 0 Methyltransferase TRM13 RNA_pol_Rbc25 PF08292.12 CDI78588.1 - 1.8 8.8 10.1 4.7 7.5 10.4 1.5 2 0 0 2 2 1 0 RNA polymerase III subunit Rpc25 ORC_WH_C PF18137.1 CDI78588.1 - 1.9 8.6 12.0 2.4 8.2 12.0 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Gti1_Pac2 PF09729.9 CDI78588.1 - 1.9 8.6 10.1 2.3 8.3 10.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Pal1 PF08316.11 CDI78588.1 - 2 9.2 5.7 2.5 8.9 5.7 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein CobT PF06213.12 CDI78588.1 - 2.1 7.6 21.4 2.9 7.2 21.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4770 PF15994.5 CDI78588.1 - 2.1 8.5 18.2 2.9 8.1 18.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) AIF_C PF14721.6 CDI78588.1 - 2.6 8.4 13.1 3.3 8.1 13.1 1.2 1 1 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term ABC2_membrane_2 PF12679.7 CDI78588.1 - 2.9 7.1 8.7 4.3 6.5 8.7 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein BRF1 PF07741.13 CDI78588.1 - 3.2 8.2 11.7 4.3 7.7 11.7 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain MDM10 PF12519.8 CDI78588.1 - 3.4 6.4 11.4 4.2 6.1 11.4 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF2371 PF10177.9 CDI78588.1 - 4.2 7.5 6.1 14 5.9 6.1 1.8 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) ALMT PF11744.8 CDI78588.1 - 4.7 5.9 9.7 5.9 5.6 9.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4407 PF14362.6 CDI78588.1 - 6.1 6.1 16.0 8.1 5.7 16.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EPL1 PF10513.9 CDI78588.1 - 6.8 7.1 15.6 8.3 6.8 15.6 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like RBM39linker PF15519.6 CDI78588.1 - 7.1 7.8 14.5 11 7.2 14.5 1.2 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein Paf1 PF03985.13 CDI78588.1 - 7.5 5.4 16.6 8.9 5.2 16.6 1.0 1 0 0 1 1 1 0 Paf1 DUF4638 PF15472.6 CDI78588.1 - 8.4 6.0 12.6 11 5.7 12.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) MctB PF11382.8 CDI78588.1 - 8.8 5.9 13.8 11 5.6 13.8 1.1 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB PepSY_TM PF03929.16 CDI78588.1 - 9 5.9 9.4 11 5.5 9.4 1.2 1 0 0 1 1 1 0 PepSY-associated TM region CDC45 PF02724.14 CDI78590.1 - 1.2 7.3 19.2 1.4 7.1 19.2 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI78590.1 - 1.4 7.8 22.0 1.6 7.6 22.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Hamartin PF04388.12 CDI78590.1 - 2.3 6.8 23.7 2.4 6.7 23.7 1.0 1 0 0 1 1 1 0 Hamartin protein SOG2 PF10428.9 CDI78590.1 - 3.7 6.6 24.5 4.9 6.2 24.5 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein PA26 PF04636.13 CDI78590.1 - 4 6.3 16.4 4.8 6.0 16.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Raftlin PF15250.6 CDI78590.1 - 9.1 4.9 20.0 10 4.8 20.0 1.1 1 0 0 1 1 1 0 Raftlin SUIM_assoc PF16619.5 CDI78594.1 - 1.8e-05 24.7 0.1 0.0082 16.2 0.1 8.8 4 3 2 6 6 6 3 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI78594.1 - 0.0088 16.4 22.2 0.0088 16.4 22.2 5.4 1 1 2 3 3 3 1 Anti-sigma-K factor rskA RloB PF13707.6 CDI78594.1 - 2.4 8.3 14.0 3.1 8.0 0.8 3.3 2 1 1 3 3 3 0 RloB-like protein Activator_LAG-3 PF11498.8 CDI78595.1 - 0.00045 19.3 27.5 0.00045 19.3 27.5 3.6 4 1 0 4 4 4 2 Transcriptional activator LAG-3 RusA PF05866.11 CDI78595.1 - 8 7.0 9.4 12 6.5 7.6 2.3 2 0 0 2 2 2 0 Endodeoxyribonuclease RusA SARAF PF06682.12 CDI78603.1 - 0.00021 21.1 9.4 0.00021 21.1 9.4 5.0 1 1 2 4 4 4 2 SOCE-associated regulatory factor of calcium homoeostasis RskA PF10099.9 CDI78603.1 - 0.0011 19.3 0.0 0.0011 19.3 0.0 9.1 2 2 4 6 6 6 3 Anti-sigma-K factor rskA Pkinase PF00069.25 CDI78653.1 - 9.1e-14 51.4 0.0 1.5e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI78653.1 - 3.4e-06 26.5 0.8 6.3e-06 25.7 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase TFIIA PF03153.13 CDI78653.1 - 2.2 8.2 14.5 2.6 8.0 14.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.25 CDI78657.1 - 3e-19 69.4 0.1 1.4e-10 41.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI78657.1 - 0.00062 19.1 0.0 0.0012 18.2 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Metallophos PF00149.28 CDI78660.1 - 0.0004 20.9 0.0 0.00067 20.2 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase GramPos_pilinD1 PF16555.5 CDI78662.1 - 0.18 12.0 4.7 0.38 10.9 4.6 1.7 1 1 0 1 1 1 0 Gram-positive pilin subunit D1, N-terminal domain DUF883 PF05957.13 CDI78662.1 - 0.39 11.4 12.3 3.6 8.3 3.5 3.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Caprin-1_dimer PF18293.1 CDI78662.1 - 2.1 8.9 13.7 1.1 9.7 3.6 2.3 2 0 0 2 2 2 0 Caprin-1 dimerization domain YabA PF06156.13 CDI78662.1 - 2.3 8.9 22.4 0.28 11.8 4.7 2.7 1 1 1 2 2 2 0 Initiation control protein YabA DUF4407 PF14362.6 CDI78662.1 - 7.5 5.8 21.4 13 5.1 21.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OmpH PF03938.14 CDI78662.1 - 8 6.8 49.9 0.71 10.2 18.9 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) PPI_Ypi1 PF07491.11 CDI78666.1 - 5.5e-21 74.2 0.0 1.1e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase inhibitor Pkinase PF00069.25 CDI78667.1 - 8.2e-16 58.1 0.0 2.7e-13 49.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Kinase-like PF14531.6 CDI78667.1 - 2e-13 50.3 0.0 1.6e-12 47.3 0.0 2.0 1 1 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 CDI78667.1 - 2.3e-06 27.1 0.0 3.7e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDI78669.1 - 4.2e-13 49.3 0.0 4.9e-12 45.8 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CDI78669.1 - 1e-08 34.9 0.0 2.3e-08 33.7 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 CDI78669.1 - 0.00022 20.6 0.0 0.00033 20.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3591 PF12157.8 CDI78673.1 - 9.8e-26 90.4 0.0 7.6e-25 87.5 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3591) Bromodomain PF00439.25 CDI78673.1 - 6.2e-16 58.2 0.0 1.2e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Bromodomain DUF1487 PF07368.11 CDI78673.1 - 0.22 11.0 0.0 0.41 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) Hormone_4 PF00220.17 CDI78673.1 - 1.4 9.0 6.3 1.1 9.4 0.6 2.8 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain Patched PF02460.18 CDI78675.1 - 4.8e-88 296.2 2.5 2.3e-51 174.9 0.2 3.2 3 1 0 3 3 3 2 Patched family Sterol-sensing PF12349.8 CDI78675.1 - 3.8e-26 91.8 3.7 3.8e-26 91.8 3.7 2.1 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 CDI78675.1 - 2.5e-06 25.5 7.8 2.6e-05 22.1 9.8 1.6 2 0 0 2 2 2 1 AcrB/AcrD/AcrF family DUF3247 PF11607.8 CDI78675.1 - 0.066 13.5 0.0 0.22 11.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) Macoilin PF09726.9 CDI78675.1 - 3.6 6.0 26.6 8.7 4.8 26.6 1.6 1 0 0 1 1 1 0 Macoilin family Ank_2 PF12796.7 CDI78676.1 - 5.2e-22 78.2 6.6 0.00011 22.7 0.1 6.3 3 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI78676.1 - 8.9e-15 54.9 5.5 0.0022 18.5 0.1 6.5 5 2 1 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.30 CDI78676.1 - 1.8e-14 53.4 21.9 0.0001 22.6 0.0 8.6 8 1 0 8 8 8 4 Ankyrin repeat Ank_3 PF13606.6 CDI78676.1 - 2.3e-14 52.0 14.5 0.0001 22.4 0.0 9.3 10 0 0 10 10 10 3 Ankyrin repeat Ank_5 PF13857.6 CDI78676.1 - 3.4e-10 40.0 2.3 0.0011 19.2 0.0 6.4 5 1 1 6 6 6 1 Ankyrin repeats (many copies) DUF555 PF04475.12 CDI78676.1 - 0.029 14.7 0.1 0.078 13.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF555) DUF620 PF04788.12 CDI78676.1 - 0.14 11.6 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF620) cEGF PF12662.7 CDI78677.1 - 0.099 12.6 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Complement Clr-like EGF-like EGF PF00008.27 CDI78677.1 - 0.74 10.2 3.4 1.4 9.3 3.4 1.5 1 0 0 1 1 1 0 EGF-like domain TFIIA PF03153.13 CDI78678.1 - 0.00071 19.7 40.4 0.00071 19.7 40.4 2.4 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit SID-1_RNA_chan PF13965.6 CDI78678.1 - 0.0061 15.0 4.5 0.026 12.9 2.9 2.1 2 0 0 2 2 2 1 dsRNA-gated channel SID-1 Yip1 PF04893.17 CDI78678.1 - 0.0069 16.1 6.8 0.63 9.7 2.5 2.6 2 0 0 2 2 2 2 Yip1 domain DUF2126 PF09899.9 CDI78678.1 - 0.093 10.8 15.0 0.02 13.0 11.1 1.7 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) RR_TM4-6 PF06459.12 CDI78678.1 - 0.1 12.4 23.0 0.012 15.4 18.1 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 KASH PF10541.9 CDI78678.1 - 0.15 12.3 2.0 0.38 11.0 2.0 1.6 1 0 0 1 1 1 0 Nuclear envelope localisation domain Mit_KHE1 PF10173.9 CDI78678.1 - 0.22 11.6 9.9 0.051 13.7 5.7 2.0 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related SUIM_assoc PF16619.5 CDI78678.1 - 0.35 11.0 0.0 0.35 11.0 0.0 5.8 2 1 1 3 3 2 0 Unstructured region C-term to UIM in Ataxin3 YajC PF02699.15 CDI78678.1 - 0.56 10.1 0.0 0.56 10.1 0.0 5.0 2 1 1 3 3 1 0 Preprotein translocase subunit Tmemb_9 PF05434.11 CDI78678.1 - 0.56 10.1 0.0 0.56 10.1 0.0 2.6 2 1 0 2 2 1 0 TMEM9 TT_ORF1 PF02956.14 CDI78678.1 - 0.74 8.4 17.9 1.2 7.7 17.9 1.3 1 0 0 1 1 1 0 TT viral orf 1 CLN3 PF02487.17 CDI78678.1 - 0.77 8.7 20.1 5.5 5.9 0.0 2.3 2 0 0 2 2 2 0 CLN3 protein Spo7 PF03907.13 CDI78678.1 - 0.89 9.0 5.8 0.43 10.0 3.0 1.8 2 0 0 2 2 2 0 Spo7-like protein DUF4834 PF16118.5 CDI78678.1 - 0.94 10.5 0.0 0.94 10.5 0.0 4.1 2 1 0 2 2 1 0 Domain of unknown function (DUF4834) DUF4746 PF15928.5 CDI78678.1 - 1.7 8.0 14.7 3.2 7.1 14.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) eIF-3_zeta PF05091.12 CDI78678.1 - 1.7 7.5 31.4 0.071 12.1 25.3 1.6 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PIP5K PF01504.18 CDI78678.1 - 1.7 7.8 16.6 14 4.8 17.1 2.0 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase FapA PF03961.13 CDI78678.1 - 2.1 6.9 11.8 3 6.4 11.8 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Presenilin PF01080.17 CDI78678.1 - 2.3 6.9 31.4 2.3 6.9 28.3 2.3 3 0 0 3 3 3 0 Presenilin Afi1 PF07792.12 CDI78678.1 - 2.9 8.4 22.3 0.7 10.4 18.2 2.0 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking NPR3 PF03666.13 CDI78678.1 - 3.8 6.2 21.4 7.3 5.3 21.4 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SpoIIP PF07454.11 CDI78678.1 - 4.5 6.7 25.1 0.33 10.4 20.1 1.6 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) MDM10 PF12519.8 CDI78678.1 - 5.3 5.8 20.6 4.9 5.9 18.5 1.8 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 PPL5 PF18168.1 CDI78678.1 - 8.5 5.6 16.0 18 4.5 16.0 1.5 1 0 0 1 1 1 0 Prim-pol family 5 DUF1387 PF07139.11 CDI78678.1 - 8.5 6.0 27.4 1.2 8.8 21.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) Acetyltransf_1 PF00583.25 CDI78684.1 - 0.0028 17.9 0.0 0.0053 17.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDI78684.1 - 0.0068 16.8 0.0 0.012 16.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Peptidase_M41 PF01434.18 CDI78685.1 - 1.4e-43 149.0 0.1 1.3e-42 145.8 0.0 2.4 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 CDI78685.1 - 5.2e-11 43.1 0.4 0.00026 21.4 0.1 3.2 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDI78685.1 - 0.0068 16.8 0.5 0.076 13.4 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 CDI78685.1 - 0.0072 15.7 0.1 0.022 14.2 0.1 1.8 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CDI78685.1 - 0.036 14.3 0.0 0.2 11.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CDI78685.1 - 0.042 13.8 0.1 0.098 12.7 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 CDI78685.1 - 0.061 12.8 1.4 0.075 12.5 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region Cwf_Cwc_15 PF04889.12 CDI78685.1 - 3.5 7.3 32.8 1.7 8.3 22.7 2.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SPX PF03105.19 CDI78685.1 - 4.1 7.2 22.9 1.5 8.7 5.3 2.4 2 0 0 2 2 2 0 SPX domain DEAD PF00270.29 CDI78686.1 - 3.6e-34 118.0 0.0 2.2e-24 86.2 0.0 2.2 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 CDI78686.1 - 0.00049 20.1 0.0 0.0012 18.9 0.0 1.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDI78686.1 - 0.0028 17.9 0.1 0.45 10.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 CDI78686.1 - 0.01 15.8 0.2 0.023 14.6 0.2 1.5 1 0 0 1 1 1 1 NACHT domain MTS PF05175.14 CDI78692.1 - 2.1e-10 40.4 0.3 3.2e-05 23.6 0.0 2.1 1 1 1 2 2 2 2 Methyltransferase small domain Methyltrans_SAM PF10672.9 CDI78692.1 - 1.5e-09 37.4 0.1 2.2e-07 30.3 0.0 2.1 2 0 0 2 2 2 2 S-adenosylmethionine-dependent methyltransferase Cons_hypoth95 PF03602.15 CDI78692.1 - 6.8e-06 25.8 0.5 0.074 12.7 0.6 2.1 2 0 0 2 2 2 2 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 CDI78692.1 - 0.00018 22.1 0.2 0.0055 17.4 0.2 2.3 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI78692.1 - 0.00027 20.7 0.0 0.18 11.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.7 CDI78692.1 - 0.0019 18.1 0.0 0.0031 17.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain N6-adenineMlase PF10237.9 CDI78692.1 - 0.0044 16.9 0.0 0.0067 16.2 0.0 1.2 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase PrmA PF06325.13 CDI78692.1 - 0.0079 15.6 1.0 0.011 15.2 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_24 PF13578.6 CDI78692.1 - 0.038 15.0 1.1 0.12 13.4 1.1 1.9 1 1 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.18 CDI78692.1 - 0.04 13.6 0.0 8 6.1 0.0 2.1 1 1 0 2 2 2 0 Putative RNA methylase family UPF0020 Methyltransf_11 PF08241.12 CDI78692.1 - 0.052 14.2 0.2 5.7 7.7 0.2 2.4 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 CDI78692.1 - 0.2 10.9 0.0 21 4.3 0.0 2.2 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Activator_LAG-3 PF11498.8 CDI78699.1 - 1.7e-06 27.3 67.6 0.0007 18.7 45.1 3.5 3 0 0 3 3 3 2 Transcriptional activator LAG-3 SR-25 PF10500.9 CDI78699.1 - 0.004 16.8 3.2 0.004 16.8 3.2 3.0 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein V_ATPase_I PF01496.19 CDI78699.1 - 2.9 5.7 22.9 5.2 4.9 22.9 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SID-1_RNA_chan PF13965.6 CDI78699.1 - 4.2 5.6 10.1 6.5 5.0 10.1 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 eIF-3_zeta PF05091.12 CDI78699.1 - 5.5 5.8 28.5 10 4.9 28.5 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FliO PF04347.13 CDI78739.1 - 0.014 15.7 0.3 0.082 13.2 0.3 2.4 1 0 0 1 1 1 0 Flagellar biosynthesis protein, FliO CRM1_C PF08767.11 CDI78770.1 - 1e-84 284.5 10.8 1.1e-83 281.1 3.4 3.1 2 1 1 3 3 3 2 CRM1 C terminal CRM1_repeat_3 PF18787.1 CDI78770.1 - 2.2e-09 37.2 0.3 9.6e-07 28.8 0.0 3.5 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 Vac14_Fab1_bd PF12755.7 CDI78770.1 - 0.31 11.7 2.3 1.7 9.3 0.0 2.9 3 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region rve PF00665.26 CDI78777.1 - 2.8e-12 46.9 0.1 6.5e-11 42.5 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain Biotin_carb_C PF02785.19 CDI78777.1 - 9.2e-05 22.5 0.0 0.16 12.0 0.0 2.4 2 0 0 2 2 2 2 Biotin carboxylase C-terminal domain DUF3288 PF11691.8 CDI78777.1 - 0.02 15.0 0.6 15 5.7 0.0 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3288) rve_3 PF13683.6 CDI78777.1 - 0.079 12.8 0.2 0.18 11.6 0.2 1.5 1 0 0 1 1 1 0 Integrase core domain DUF2497 PF10691.9 CDI78777.1 - 0.21 12.1 0.9 3 8.4 0.0 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2497) RRP36 PF06102.12 CDI78777.1 - 0.22 11.5 0.4 11 5.9 0.0 2.6 2 1 0 2 2 2 0 rRNA biogenesis protein RRP36 HAUS4 PF14735.6 CDI78782.1 - 0.076 12.7 1.6 0.13 12.0 1.6 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 Antimicrobial12 PF08107.11 CDI78782.1 - 0.21 11.4 0.2 0.4 10.5 0.2 1.4 1 0 0 1 1 1 0 Pleurocidin family TFIIA PF03153.13 CDI78784.1 - 0.0088 16.1 31.1 0.011 15.7 31.1 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI78784.1 - 0.029 14.0 21.4 0.43 10.2 9.5 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein eIF-3_zeta PF05091.12 CDI78784.1 - 0.06 12.3 6.7 0.068 12.1 6.7 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Roughex PF06020.11 CDI78784.1 - 0.34 10.0 6.7 0.48 9.5 6.7 1.3 1 0 0 1 1 1 0 Drosophila roughex protein CTU2 PF10288.9 CDI78784.1 - 0.79 10.0 14.5 0.85 9.9 10.6 2.2 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 DUF4834 PF16118.5 CDI78784.1 - 2.1 9.3 16.4 8.7 7.4 12.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Rxt3 PF08642.10 CDI78784.1 - 6.5 7.5 9.1 6.6 7.5 6.1 2.0 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 FAM176 PF14851.6 CDI78784.1 - 8.8 6.0 10.6 13 5.4 8.2 2.0 2 0 0 2 2 2 0 FAM176 family TFIIA PF03153.13 CDI78785.1 - 0.00065 19.8 52.8 0.00092 19.3 52.8 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 CDI78785.1 - 0.00068 18.7 17.2 0.0007 18.7 17.2 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF1980 PF09323.10 CDI78785.1 - 0.001 19.0 7.2 0.0014 18.5 7.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1980) SID-1_RNA_chan PF13965.6 CDI78785.1 - 0.0019 16.7 4.6 0.0021 16.6 4.6 1.2 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 SARAF PF06682.12 CDI78785.1 - 0.0027 17.4 12.2 0.0039 16.9 12.2 1.3 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis SLC12 PF03522.15 CDI78785.1 - 0.0032 16.5 10.1 0.0034 16.5 10.1 1.2 1 0 0 1 1 1 1 Solute carrier family 12 Rrn6 PF10214.9 CDI78785.1 - 0.0038 15.8 15.4 0.0036 15.9 15.4 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor O-antigen_lig PF13425.6 CDI78785.1 - 0.0081 15.0 2.0 0.0089 14.9 2.0 1.1 1 0 0 1 1 1 1 O-antigen ligase like membrane protein CSG2 PF16965.5 CDI78785.1 - 0.0093 15.0 10.8 0.011 14.7 10.8 1.1 1 0 0 1 1 1 1 Ceramide synthase regulator Connexin PF00029.19 CDI78785.1 - 0.011 15.6 8.7 0.013 15.2 8.7 1.3 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 CDI78785.1 - 0.017 13.0 15.9 0.022 12.7 15.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PIP5K PF01504.18 CDI78785.1 - 0.023 13.9 11.3 0.031 13.5 11.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase SpoIIP PF07454.11 CDI78785.1 - 0.057 12.9 17.8 0.087 12.3 17.8 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RPOL_N PF14700.6 CDI78785.1 - 0.057 12.8 20.7 0.08 12.3 20.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal LMBR1 PF04791.16 CDI78785.1 - 0.39 9.6 6.9 0.41 9.5 6.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein FAM176 PF14851.6 CDI78785.1 - 0.6 9.8 9.3 1.1 8.9 9.3 1.5 1 0 0 1 1 1 0 FAM176 family DUF4446 PF14584.6 CDI78785.1 - 0.64 10.0 6.8 1.1 9.2 6.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) CLN3 PF02487.17 CDI78785.1 - 5.2 6.0 20.8 10 5.1 20.7 1.6 1 1 0 1 1 1 0 CLN3 protein RskA PF10099.9 CDI78789.1 - 2.8e-07 31.0 0.1 2.8e-07 31.0 0.1 2.4 1 1 1 2 2 2 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI78789.1 - 0.0018 17.9 29.5 0.0018 17.9 29.5 1.9 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein SID-1_RNA_chan PF13965.6 CDI78789.1 - 0.95 7.8 3.6 1.1 7.6 3.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CCDC106 PF15794.5 CDI78789.1 - 2 8.1 24.2 4.3 7.0 24.2 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CDC45 PF02724.14 CDI78789.1 - 7.5 4.7 14.7 9.8 4.3 14.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.9 CDI78789.1 - 8.2 4.8 20.5 11 4.5 20.5 1.2 1 0 0 1 1 1 0 Macoilin family His_Phos_1 PF00300.22 CDI78802.1 - 5e-38 130.7 0.0 1.4e-30 106.4 0.1 2.4 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) DNA_primase_lrg PF04104.14 CDI78803.1 - 2.4e-05 23.9 0.0 0.0026 17.2 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic and archaeal DNA primase, large subunit DUF3235 PF11574.8 CDI78803.1 - 0.024 15.5 1.4 0.046 14.6 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) Ribosomal_60s PF00428.19 CDI78803.1 - 0.64 10.6 10.1 1.8 9.2 5.9 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein Mitofilin PF09731.9 CDI78806.1 - 4.1 6.1 50.1 5.5 5.7 50.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein SR-25 PF10500.9 CDI78824.1 - 0.1 12.2 16.0 0.15 11.7 16.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MecA PF05389.12 CDI78824.1 - 0.91 9.1 9.8 1 9.0 9.8 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Roughex PF06020.11 CDI78824.1 - 1.3 8.1 14.2 1.5 7.8 14.2 1.0 1 0 0 1 1 1 0 Drosophila roughex protein SAE2 PF08573.10 CDI78824.1 - 2 9.6 13.3 2.5 9.3 13.3 1.2 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Cas1_AcylT PF07779.12 CDI78824.1 - 2 7.2 5.5 2.6 6.9 5.5 1.1 1 0 0 1 1 1 0 10 TM Acyl Transferase domain found in Cas1p BAF1_ABF1 PF04684.13 CDI78824.1 - 2.4 7.1 27.9 2.6 7.0 27.9 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor TCP PF03634.13 CDI78824.1 - 2.6 8.6 19.9 3.3 8.2 19.9 1.1 1 0 0 1 1 1 0 TCP family transcription factor OAD_gamma PF04277.13 CDI78824.1 - 2.8 8.6 10.7 2.6 8.7 0.3 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain MCU PF04678.13 CDI78824.1 - 3.6 7.7 8.4 3.9 7.5 8.4 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter STAC2_u1 PF16664.5 CDI78824.1 - 3.7 8.0 14.8 5.1 7.6 14.8 1.3 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 DUF2992 PF11208.8 CDI78824.1 - 4.3 7.6 16.7 5.6 7.2 16.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) ALMT PF11744.8 CDI78824.1 - 4.7 5.9 19.9 5.6 5.7 19.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3824 PF12868.7 CDI78824.1 - 6.3 7.5 19.2 0.61 10.8 14.4 1.8 2 1 0 2 2 2 0 Domain of unknwon function (DUF3824) FA_desaturase PF00487.24 CDI78835.1 - 0.15 11.9 0.4 0.23 11.2 0.4 1.3 1 0 0 1 1 1 0 Fatty acid desaturase B12D PF06522.11 CDI78835.1 - 0.24 11.2 5.0 1.9 8.4 5.0 2.5 1 1 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit LMF1 PF06762.14 CDI78835.1 - 0.66 9.0 3.1 0.8 8.7 3.1 1.2 1 0 0 1 1 1 0 Lipase maturation factor SID-1_RNA_chan PF13965.6 CDI78835.1 - 2.2 6.6 13.5 0.025 13.0 5.4 1.8 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 LRRC37AB_C PF14914.6 CDI78837.1 - 0.018 14.9 4.3 0.028 14.3 4.3 1.3 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF4692 PF15763.5 CDI78837.1 - 0.046 14.2 2.0 0.05 14.1 2.0 1.1 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Presenilin PF01080.17 CDI78837.1 - 0.4 9.4 7.1 0.42 9.3 7.1 1.0 1 0 0 1 1 1 0 Presenilin DUF755 PF05501.11 CDI78837.1 - 1.2 9.4 21.9 2.2 8.5 22.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF755) Spt20 PF12090.8 CDI78837.1 - 2.9 7.5 15.8 3.2 7.3 15.8 1.1 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 CDI78850.1 - 1.5e-05 24.0 22.1 1.5e-05 24.0 22.1 3.8 3 1 0 3 3 3 2 Presenilin Cytochrom_B558a PF05038.13 CDI78850.1 - 0.0015 18.1 0.3 0.0015 18.1 0.3 3.0 3 3 2 5 5 5 1 Cytochrome Cytochrome b558 alpha-subunit HHH_2 PF12826.7 CDI78850.1 - 0.015 15.4 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif Tudor-knot PF11717.8 CDI78850.1 - 0.015 15.2 0.1 0.068 13.1 0.1 2.2 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain TCP PF03634.13 CDI78850.1 - 0.099 13.2 69.3 0.35 11.4 13.4 4.3 4 0 0 4 4 4 0 TCP family transcription factor Pribosyltran PF00156.27 CDI78850.1 - 0.57 9.7 1.8 1 8.9 0.0 2.4 2 0 0 2 2 2 0 Phosphoribosyl transferase domain DUF2052 PF09747.9 CDI78850.1 - 0.66 10.1 71.1 0.15 12.1 23.6 4.1 4 0 0 4 4 4 0 Coiled-coil domain containing protein (DUF2052) BORG_CEP PF14957.6 CDI78850.1 - 0.96 10.6 54.0 0.41 11.8 18.2 4.5 4 0 0 4 4 4 0 Cdc42 effector PsbQ PF05757.11 CDI78865.1 - 0.0089 15.8 4.9 0.0089 15.8 4.9 2.1 2 0 0 2 2 2 1 Oxygen evolving enhancer protein 3 (PsbQ) Shadoo PF14999.6 CDI78865.1 - 0.083 13.0 7.6 1 9.4 2.6 2.4 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective DUF4834 PF16118.5 CDI78865.1 - 0.14 13.1 4.8 8.8 7.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Neur_chan_memb PF02932.16 CDI78865.1 - 0.15 12.1 1.1 0.25 11.3 1.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SYS1 PF09801.9 CDI78865.1 - 0.18 12.0 0.2 0.26 11.4 0.2 1.2 1 0 0 1 1 1 0 Integral membrane protein S linking to the trans Golgi network DUF1980 PF09323.10 CDI78865.1 - 0.32 10.9 3.4 1.3 8.9 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF2214 PF09980.9 CDI78865.1 - 0.37 10.6 2.6 0.18 11.6 0.2 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2214) Methyltransf_12 PF08242.12 CDI78865.1 - 1.1 10.1 3.3 0.91 10.3 0.3 2.1 1 1 1 2 2 2 0 Methyltransferase domain DUF2681 PF10883.8 CDI78865.1 - 4 7.9 18.4 1.5 9.3 2.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) 60KD_IMP PF02096.20 CDI78865.1 - 4.4 7.2 8.0 1 9.2 0.2 2.2 2 0 0 2 2 2 0 60Kd inner membrane protein RskA PF10099.9 CDI78865.1 - 5 7.4 31.0 2.6e+03 -1.5 31.1 2.3 1 1 0 1 1 1 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI78865.1 - 5.1 7.0 22.8 8.1 6.3 22.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TAF4 PF05236.14 CDI78870.1 - 0.00069 19.5 5.4 0.00069 19.5 5.4 4.2 3 2 1 4 4 4 1 Transcription initiation factor TFIID component TAF4 family POX PF07526.11 CDI78870.1 - 0.018 15.6 8.1 0.018 15.6 8.1 3.4 3 0 0 3 3 3 0 Associated with HOX EPL1 PF10513.9 CDI78870.1 - 0.39 11.1 26.1 0.087 13.2 5.8 3.0 3 0 0 3 3 3 0 Enhancer of polycomb-like BAF1_ABF1 PF04684.13 CDI78870.1 - 0.6 9.1 34.0 0.028 13.5 6.8 3.2 3 0 0 3 3 3 0 BAF1 / ABF1 chromatin reorganising factor SR-25 PF10500.9 CDI78870.1 - 3.4 7.2 39.8 0.091 12.4 13.8 3.2 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein DUF3464 PF11947.8 CDI78870.1 - 6.9 6.4 26.6 0.069 12.9 0.9 3.1 3 0 0 3 3 3 0 Photosynthesis affected mutant 68 RNA_pol_Rpc4 PF05132.14 CDI78870.1 - 9 6.7 31.1 0.3 11.5 2.9 3.4 3 0 0 3 3 3 0 RNA polymerase III RPC4 Sterol-sensing PF12349.8 CDI78883.1 - 8.2e-06 25.7 1.7 3.2e-05 23.8 1.7 2.0 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation DUF1645 PF07816.11 CDI78883.1 - 0.0063 17.1 1.6 0.0063 17.1 1.6 5.4 4 1 1 5 5 5 1 Protein of unknown function (DUF1645) Otopetrin PF03189.13 CDI78883.1 - 0.0091 14.9 0.0 0.89 8.3 0.0 2.9 2 2 0 2 2 2 1 Otopetrin Patched PF02460.18 CDI78883.1 - 0.0095 14.1 0.1 0.0095 14.1 0.1 2.5 3 0 0 3 3 3 1 Patched family FSA_C PF10479.9 CDI78894.1 - 0.89 7.6 11.0 0.94 7.5 11.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SSP160 PF06933.11 CDI78894.1 - 1.6 6.9 24.5 1.8 6.7 24.5 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RIFIN PF02009.16 CDI78894.1 - 3.8 7.3 9.1 5.5 6.8 9.1 1.2 1 0 0 1 1 1 0 Rifin SAP130_C PF16014.5 CDI78894.1 - 9 5.3 15.8 11 5.0 15.8 1.1 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus CD20 PF04103.15 CDI78895.1 - 1.1 9.3 0.0 1.1 9.3 0.0 5.2 5 2 1 6 6 6 0 CD20-like family DUF4647 PF15504.6 CDI78899.1 - 0.33 10.0 20.0 0.38 9.8 20.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Sin_N PF04801.13 CDI78899.1 - 0.46 9.6 26.4 0.58 9.3 26.4 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region PNISR PF15996.5 CDI78899.1 - 0.8 9.9 24.5 1 9.6 24.5 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Utp14 PF04615.13 CDI78899.1 - 1 7.9 19.9 1.2 7.6 19.9 1.0 1 0 0 1 1 1 0 Utp14 protein Totivirus_coat PF05518.11 CDI78899.1 - 1 7.3 11.4 1.1 7.2 11.4 1.0 1 0 0 1 1 1 0 Totivirus coat protein Asp-B-Hydro_N PF05279.11 CDI78899.1 - 1.4 9.0 7.5 1.6 8.7 7.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region BAF1_ABF1 PF04684.13 CDI78899.1 - 1.8 7.5 25.3 2.3 7.2 25.3 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor ORC_WH_C PF18137.1 CDI78899.1 - 2 8.5 11.9 4.1 7.5 11.9 1.5 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Peptidase_S64 PF08192.11 CDI78899.1 - 2.6 6.4 29.2 3.2 6.1 29.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 LAP1C PF05609.12 CDI78899.1 - 3.3 6.7 23.4 3.7 6.5 23.4 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SPX PF03105.19 CDI78899.1 - 3.8 7.3 28.7 4.5 7.1 28.7 1.0 1 0 0 1 1 1 0 SPX domain Paramyxo_ncap PF00973.19 CDI78899.1 - 6.2 5.6 16.2 6.9 5.5 16.2 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein SpoIIIAH PF12685.7 CDI78899.1 - 6.8 6.5 26.7 8.9 6.1 26.7 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Neur_chan_memb PF02932.16 CDI78899.1 - 6.9 6.7 18.4 8.5 6.4 18.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 CDI78899.1 - 9.1 4.4 16.3 11 4.2 16.3 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI78899.1 - 9.7 5.1 23.3 14 4.6 23.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF4407 PF14362.6 CDI78899.1 - 9.8 5.4 14.2 14 4.9 14.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3446 PF11928.8 CDI78900.1 - 0.00018 21.7 20.3 0.0016 18.7 9.2 2.2 2 0 0 2 2 2 2 Early growth response N-terminal domain Secretin_N_2 PF07655.13 CDI78900.1 - 0.0011 19.5 22.4 0.074 13.6 5.5 2.2 2 0 0 2 2 2 2 Secretin N-terminal domain Apt1 PF10351.9 CDI78900.1 - 0.011 14.6 8.4 0.013 14.4 8.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 CDI78900.1 - 0.15 11.9 7.2 0.24 11.3 7.2 1.3 1 0 0 1 1 1 0 SPX domain DUF3123 PF11321.8 CDI78900.1 - 0.19 12.4 5.4 2.6 8.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) Chorion_2 PF03964.15 CDI78900.1 - 0.24 12.3 12.4 0.14 13.0 3.6 2.2 2 0 0 2 2 2 0 Chorion family 2 PP2C PF00481.21 CDI78902.1 - 1.8e-33 116.3 0.0 4.3e-33 115.0 0.0 1.6 2 0 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.6 CDI78902.1 - 0.0036 17.0 0.0 0.011 15.4 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C YjgF_endoribonc PF14588.6 CDI78902.1 - 0.053 13.7 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 YjgF/chorismate_mutase-like, putative endoribonuclease CKS PF01111.19 CDI78904.1 - 2e-21 76.0 0.0 4.1e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit PIGA PF08288.12 CDI78905.1 - 1e-38 131.8 3.2 2.3e-38 130.7 3.2 1.6 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 CDI78905.1 - 3.3e-18 66.2 4.1 7.8e-18 65.0 4.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 CDI78905.1 - 1.6e-11 44.8 0.2 9.5e-05 22.8 0.3 2.5 1 1 1 2 2 2 2 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDI78905.1 - 9.9e-11 41.5 0.0 8e-05 22.2 0.0 2.5 1 1 1 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDI78905.1 - 6.8e-07 29.9 0.1 2.2e-05 25.0 0.0 2.6 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 CDI78905.1 - 7.9e-05 23.0 0.0 0.00021 21.6 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 CDI78905.1 - 0.0022 18.0 0.3 0.0039 17.2 0.3 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like DUF4179 PF13786.6 CDI78913.1 - 0.0066 16.9 18.1 17 6.0 1.2 7.9 6 3 0 6 6 6 3 Domain of unknown function (DUF4179) DUF4746 PF15928.5 CDI78915.1 - 0.47 9.8 17.8 0.53 9.7 17.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TCP PF03634.13 CDI78915.1 - 0.78 10.3 22.9 0.88 10.1 22.9 1.1 1 0 0 1 1 1 0 TCP family transcription factor V_ATPase_I PF01496.19 CDI78915.1 - 0.99 7.2 26.5 1.1 7.1 26.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CPSF100_C PF13299.6 CDI78915.1 - 1.3 9.1 18.0 2 8.6 18.0 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 CDI78915.1 - 1.4 7.6 27.1 1.4 7.6 27.1 1.0 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 CDI78915.1 - 2 7.4 20.7 2.2 7.2 20.7 1.0 1 0 0 1 1 1 0 CLN3 protein CobT PF06213.12 CDI78915.1 - 2.4 7.5 30.6 2.6 7.4 30.6 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Connexin PF00029.19 CDI78915.1 - 3.1 7.5 18.2 4 7.1 18.2 1.2 1 0 0 1 1 1 0 Connexin Pex14_N PF04695.13 CDI78915.1 - 4.5 7.9 37.1 6.8 7.3 37.1 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CCDC53 PF10152.9 CDI78915.1 - 4.6 7.6 25.5 5.5 7.4 25.5 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex eIF-3_zeta PF05091.12 CDI78915.1 - 4.9 6.0 29.7 6.2 5.7 29.7 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARP1 PF12569.8 CDI78915.1 - 5 5.9 23.6 5.4 5.8 23.6 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Ketoacyl-synt_2 PF13723.6 CDI78915.1 - 6.4 6.3 23.7 7.5 6.1 23.7 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain CDC45 PF02724.14 CDI78915.1 - 6.5 4.9 19.4 6.2 5.0 19.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF1180 PF06679.12 CDI78915.1 - 7.6 6.9 11.7 8.9 6.7 11.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) RR_TM4-6 PF06459.12 CDI78915.1 - 7.7 6.3 25.2 8.3 6.2 25.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RskA PF10099.9 CDI78923.1 - 5.9e-08 33.2 28.6 1.8e-05 25.1 2.9 9.8 1 1 3 4 4 4 3 Anti-sigma-K factor rskA Cadherin_C_2 PF16492.5 CDI78923.1 - 0.057 14.2 0.1 0.057 14.2 0.1 7.7 5 2 0 5 5 5 0 Cadherin cytoplasmic C-terminal DEAD PF00270.29 CDI78926.1 - 1.1e-09 38.3 0.9 1.1e-09 38.3 0.9 3.8 3 2 1 4 4 4 1 DEAD/DEAH box helicase SR-25 PF10500.9 CDI78926.1 - 0.0025 17.4 63.1 0.012 15.2 19.8 4.4 4 0 0 4 4 4 3 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.19 CDI78926.1 - 0.0031 18.1 4.2 0.0031 18.1 4.2 9.9 6 2 2 8 8 8 1 60s Acidic ribosomal protein Pex14_N PF04695.13 CDI78926.1 - 0.0043 17.7 13.8 0.0043 17.7 13.8 5.6 4 1 1 5 5 5 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3464 PF11947.8 CDI78926.1 - 0.014 15.2 2.1 0.014 15.2 2.1 5.8 5 2 0 5 5 5 0 Photosynthesis affected mutant 68 N6_N4_Mtase PF01555.18 CDI78926.1 - 0.044 13.5 0.0 40 3.8 0.0 3.0 3 1 0 3 3 3 0 DNA methylase FAM76 PF16046.5 CDI78926.1 - 2.1 7.6 55.2 0.58 9.5 13.6 4.2 4 0 0 4 4 4 0 FAM76 protein GRIM-19 PF06212.12 CDI78928.1 - 0.028 14.4 10.5 0.033 14.1 0.7 3.1 3 0 0 3 3 3 0 GRIM-19 protein V_ATPase_I PF01496.19 CDI78945.1 - 0.00045 18.3 11.6 0.00049 18.2 11.6 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family YfhO PF09586.10 CDI78945.1 - 0.0018 16.6 1.6 0.0019 16.5 1.6 1.0 1 0 0 1 1 1 1 Bacterial membrane protein YfhO TctB PF07331.11 CDI78945.1 - 0.0022 18.3 0.4 0.2 11.9 1.0 2.0 1 1 1 2 2 2 1 Tripartite tricarboxylate transporter TctB family DUF4834 PF16118.5 CDI78945.1 - 0.0053 17.7 1.4 0.0053 17.7 1.4 2.7 1 1 1 2 2 1 1 Domain of unknown function (DUF4834) NnrS PF05940.12 CDI78945.1 - 0.012 15.0 3.8 0.015 14.7 3.8 1.1 1 0 0 1 1 1 0 NnrS protein SID-1_RNA_chan PF13965.6 CDI78945.1 - 0.021 13.2 0.8 0.05 12.0 0.8 1.7 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 DUF3365 PF11845.8 CDI78945.1 - 0.024 15.0 1.0 0.028 14.7 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) Oxidored_q3 PF00499.20 CDI78945.1 - 0.027 14.2 6.5 0.36 10.6 1.7 2.0 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 YajC PF02699.15 CDI78945.1 - 0.049 13.5 2.9 0.049 13.5 2.9 3.7 2 1 2 4 4 2 0 Preprotein translocase subunit NicO PF03824.16 CDI78945.1 - 0.064 12.6 7.1 0.016 14.5 1.5 1.9 1 1 1 2 2 2 0 High-affinity nickel-transport protein DUF2339 PF10101.9 CDI78945.1 - 0.073 11.6 7.3 0.083 11.5 7.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) EcsB PF05975.12 CDI78945.1 - 0.075 11.9 13.4 0.087 11.7 13.4 1.0 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB 7tm_1 PF00001.21 CDI78945.1 - 0.079 12.3 0.2 0.12 11.6 0.2 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF4131 PF13567.6 CDI78945.1 - 0.081 12.6 8.5 0.35 10.5 5.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Neur_chan_memb PF02932.16 CDI78945.1 - 0.11 12.5 2.6 0.13 12.3 2.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BatD PF13584.6 CDI78945.1 - 0.12 11.1 3.5 1.7 7.3 0.5 2.0 1 1 1 2 2 2 0 Oxygen tolerance DUF898 PF05987.13 CDI78945.1 - 0.15 11.1 3.0 0.2 10.6 3.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) DUF2298 PF10060.9 CDI78945.1 - 0.15 10.7 1.3 0.2 10.4 1.3 1.2 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) Wzy_C PF04932.15 CDI78945.1 - 0.2 11.3 1.1 0.85 9.2 1.1 1.8 1 1 0 1 1 1 0 O-Antigen ligase Cyt_bd_oxida_II PF02322.15 CDI78945.1 - 0.21 10.9 1.7 0.25 10.7 1.7 1.1 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II DUF3522 PF12036.8 CDI78945.1 - 0.37 11.1 4.7 0.15 12.4 1.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3522) Exosortase_EpsH PF09721.10 CDI78945.1 - 0.57 9.7 6.3 0.74 9.3 6.3 1.1 1 0 0 1 1 1 0 Transmembrane exosortase (Exosortase_EpsH) 7TM-7TMR_HD PF07698.11 CDI78945.1 - 0.61 9.8 10.2 0.8 9.4 10.2 1.1 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DHHC PF01529.20 CDI78945.1 - 0.69 10.0 5.0 1.2 9.2 5.0 1.5 1 1 0 1 1 1 0 DHHC palmitoyltransferase CTP_transf_1 PF01148.20 CDI78945.1 - 0.84 9.3 4.0 0.98 9.1 4.0 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family DUF4271 PF14093.6 CDI78945.1 - 0.89 9.4 11.2 1.1 9.2 3.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4271) LPG_synthase_TM PF03706.13 CDI78945.1 - 1.1 8.7 7.5 54 3.2 7.5 2.0 1 1 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region EXS PF03124.14 CDI78945.1 - 1.3 8.3 4.0 1.9 7.7 4.0 1.4 1 1 0 1 1 1 0 EXS family ABC2_membrane_2 PF12679.7 CDI78945.1 - 1.5 8.0 8.9 1.9 7.7 8.9 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein GT87 PF09594.10 CDI78945.1 - 2.2 7.9 8.8 2.7 7.6 8.8 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 87 DUF2615 PF11027.8 CDI78945.1 - 2.8 8.1 15.8 1.3 9.2 13.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2615) Intg_mem_TP0381 PF09529.10 CDI78945.1 - 2.9 7.3 7.6 20 4.6 7.6 1.9 1 1 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) Cytochrom_B_C PF00032.17 CDI78945.1 - 3 8.2 5.2 4 7.8 4.7 1.5 1 1 0 1 1 1 0 Cytochrome b(C-terminal)/b6/petD Peptidase_S49_N PF08496.10 CDI78945.1 - 3.4 7.7 12.6 13 5.8 6.5 2.3 1 1 1 2 2 2 0 Peptidase family S49 N-terminal EphA2_TM PF14575.6 CDI78945.1 - 4.8 8.1 17.6 1 10.3 0.5 3.5 1 1 1 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain DUF1345 PF07077.11 CDI78945.1 - 5 6.8 5.3 11 5.7 4.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) DUF3357 PF11837.8 CDI78945.1 - 5.5 7.5 6.9 19 5.8 2.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) DUF1461 PF07314.11 CDI78945.1 - 6.7 6.6 7.9 2.1 8.2 2.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1461) SirB PF04247.12 CDI78945.1 - 6.8 6.8 12.7 9.4 6.4 12.7 1.2 1 0 0 1 1 1 0 Invasion gene expression up-regulator, SirB TMEM154 PF15102.6 CDI78945.1 - 7 6.6 16.1 2.2 8.2 3.1 2.7 1 1 2 3 3 3 0 TMEM154 protein family PRA1 PF03208.19 CDI78945.1 - 8.2 6.1 8.5 24 4.6 8.6 1.7 1 1 0 1 1 1 0 PRA1 family protein CopD PF05425.13 CDI78945.1 - 8.4 6.9 11.7 35 4.9 4.3 2.3 1 1 1 2 2 2 0 Copper resistance protein D Peptidase_M50B PF13398.6 CDI78945.1 - 8.9 5.9 13.0 1.6e+02 1.8 13.0 2.0 1 1 0 1 1 1 0 Peptidase M50B-like Macoilin PF09726.9 CDI78948.1 - 0.093 11.3 20.6 0.11 11.0 20.6 1.1 1 0 0 1 1 1 0 Macoilin family RskA PF10099.9 CDI78948.1 - 0.36 11.1 40.3 0.17 12.2 15.6 2.7 1 1 1 2 2 2 0 Anti-sigma-K factor rskA PH_BEACH PF14844.6 CDI78948.1 - 0.73 10.0 5.8 0.16 12.1 1.1 2.2 1 1 1 2 2 2 0 PH domain associated with Beige/BEACH Folate_carrier PF01770.18 CDI78948.1 - 2.1 7.0 23.5 0.028 13.2 4.7 2.3 1 1 1 2 2 2 0 Reduced folate carrier IHABP4_N PF16174.5 CDI78948.1 - 3 8.4 35.1 2.3 8.8 6.1 2.2 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal DUF755 PF05501.11 CDI78949.1 - 0.0071 16.6 2.0 0.0071 16.6 2.0 8.8 5 4 1 6 6 6 1 Domain of unknown function (DUF755) DUF4179 PF13786.6 CDI78949.1 - 5.2 7.6 22.9 24 5.5 1.9 4.9 3 2 0 3 3 3 0 Domain of unknown function (DUF4179) Filament_head PF04732.14 CDI78949.1 - 7.8 7.4 65.8 9.2 7.2 15.8 3.7 3 0 0 3 3 3 0 Intermediate filament head (DNA binding) region 2HCT PF03390.15 CDI78954.1 - 0.007 15.0 7.1 0.0097 14.6 7.1 1.2 1 0 0 1 1 1 1 2-hydroxycarboxylate transporter family YbgS PF13985.6 CDI78954.1 - 0.015 15.6 11.1 0.019 15.3 11.1 1.2 1 0 0 1 1 1 0 YbgS-like protein DUF1754 PF08555.10 CDI78954.1 - 0.15 12.9 23.4 0.22 12.3 23.4 1.4 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) SID-1_RNA_chan PF13965.6 CDI78954.1 - 0.18 10.2 10.6 0.2 10.1 10.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Nop53 PF07767.11 CDI78954.1 - 0.46 9.8 37.9 0.5 9.7 37.9 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Tetraspanin PF00335.20 CDI78954.1 - 1.4 8.5 5.7 1.8 8.2 5.7 1.2 1 0 0 1 1 1 0 Tetraspanin family DUF913 PF06025.12 CDI78954.1 - 1.8 7.5 13.9 2.1 7.3 13.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NEMP PF10225.9 CDI78954.1 - 2.4 7.8 7.7 2.9 7.5 7.7 1.2 1 0 0 1 1 1 0 NEMP family O-antigen_lig PF13425.6 CDI78954.1 - 3.1 6.5 9.5 3.9 6.1 9.5 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Rtf2 PF04641.12 CDI78954.1 - 6.4 6.1 25.3 7.3 5.9 25.3 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Med15 PF09606.10 CDI78954.1 - 6.7 5.3 44.1 8 5.0 44.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CDC45 PF02724.14 CDI78954.1 - 10 4.3 21.5 11 4.2 21.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Otopetrin PF03189.13 CDI78960.1 - 0.00092 18.1 16.0 0.00092 18.1 16.0 5.2 2 2 0 2 2 2 1 Otopetrin Herpes_glycop PF01528.16 CDI78960.1 - 1.4 7.6 5.7 5.2 5.8 5.7 2.0 1 0 0 1 1 1 0 Herpesvirus glycoprotein M RRM_1 PF00076.22 CDI78984.1 - 3.4e-28 97.2 0.1 1e-15 57.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI78984.1 - 1.5e-07 31.4 0.0 0.0027 17.8 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 CDI78984.1 - 0.035 14.1 0.0 0.66 10.0 0.0 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif B12-binding PF02310.19 CDI78984.1 - 0.089 12.8 0.0 2.3 8.2 0.0 2.4 2 0 0 2 2 2 0 B12 binding domain tRNA-synt_2c PF01411.19 CDI78985.1 - 1e-195 651.4 0.0 1.3e-195 651.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 CDI78985.1 - 4.1e-16 58.8 0.1 9.1e-16 57.7 0.1 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 CDI78985.1 - 9.7e-06 26.0 1.1 2.6e-05 24.7 1.1 1.7 1 0 0 1 1 1 1 DHHA1 domain SARAF PF06682.12 CDI78993.1 - 0.018 14.7 20.5 0.14 11.8 0.5 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis TetR_C_33 PF13305.6 CDI78993.1 - 0.029 15.1 5.2 0.029 15.1 5.2 2.4 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain LMBR1 PF04791.16 CDI78993.1 - 0.036 13.0 3.2 0.037 12.9 3.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2828 PF11443.8 CDI78993.1 - 0.086 10.9 10.6 0.13 10.3 10.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Romo1 PF10247.9 CDI78993.1 - 0.097 13.0 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 EOS1 PF12326.8 CDI78993.1 - 0.13 12.2 9.1 9.2 6.2 9.1 2.1 1 1 0 1 1 1 0 N-glycosylation protein DUF2126 PF09899.9 CDI78993.1 - 0.18 9.8 5.3 0.3 9.1 5.3 1.4 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF5523 PF17661.1 CDI78993.1 - 0.27 10.9 20.4 1.2 8.8 20.7 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5523) DUF3408 PF11888.8 CDI78993.1 - 0.54 10.4 15.5 0.23 11.6 3.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) PAP_RNA-bind PF04926.15 CDI78993.1 - 0.75 9.4 11.1 0.95 9.1 6.4 2.4 2 0 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain Orf78 PF06024.12 CDI78993.1 - 0.86 9.9 8.7 0.68 10.3 1.4 2.6 2 0 0 2 2 2 0 Orf78 (ac78) PRC2_HTH_1 PF18118.1 CDI78993.1 - 0.94 10.3 11.2 0.76 10.6 3.7 2.5 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Zip PF02535.22 CDI78993.1 - 1.1 8.4 6.3 0.1 11.8 1.5 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter DUF2052 PF09747.9 CDI78993.1 - 1.1 9.3 16.7 1.2 9.2 14.6 1.9 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SID-1_RNA_chan PF13965.6 CDI78993.1 - 1.2 7.4 6.7 1.8 6.9 6.7 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 CDI78993.1 - 1.3 8.0 16.1 2.1 7.3 16.1 1.3 1 0 0 1 1 1 0 Solute carrier family 12 V_ATPase_I PF01496.19 CDI78993.1 - 1.4 6.7 12.9 2.4 6.0 12.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Thg1C PF14413.6 CDI78993.1 - 1.7 8.8 14.0 7.8 6.7 8.2 2.4 2 0 0 2 2 2 0 Thg1 C terminal domain PA26 PF04636.13 CDI78993.1 - 2.2 7.1 10.3 4.7 6.0 10.3 1.5 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Peroxin-13_N PF04088.13 CDI78993.1 - 2.9 8.2 19.4 0.06 13.6 6.6 2.5 1 1 1 2 2 2 0 Peroxin 13, N-terminal region Bacteriocin_IIc PF10439.9 CDI78993.1 - 3.2 8.0 13.9 6.8 6.9 13.9 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide ALMT PF11744.8 CDI78993.1 - 6.4 5.5 10.9 12 4.6 10.9 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4834 PF16118.5 CDI78993.1 - 6.7 7.7 26.2 1.9 9.5 10.0 2.7 3 0 0 3 3 2 0 Domain of unknown function (DUF4834) TOM13 PF08219.11 CDI78993.1 - 7.1 6.7 5.3 8.7 6.4 0.2 2.5 2 0 0 2 2 2 0 Outer membrane protein TOM13 Herpes_DNAp_acc PF04929.12 CDI78993.1 - 9.4 5.1 16.8 14 4.5 16.8 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Presenilin PF01080.17 CDI78993.1 - 9.6 4.8 24.2 0.91 8.2 19.6 1.5 2 0 0 2 2 2 0 Presenilin Rhodanese PF00581.20 CDI79002.1 - 2.5e-05 24.7 0.4 2.5e-05 24.7 0.4 3.5 3 2 0 3 3 3 1 Rhodanese-like domain DUF755 PF05501.11 CDI79002.1 - 0.015 15.6 16.8 0.015 15.6 16.8 6.9 6 1 1 7 7 7 0 Domain of unknown function (DUF755) DUF1645 PF07816.11 CDI79002.1 - 0.021 15.4 5.9 0.021 15.4 5.9 5.4 4 1 1 5 5 5 0 Protein of unknown function (DUF1645) DUF2298 PF10060.9 CDI79005.1 - 0.021 13.5 0.5 0.028 13.1 0.5 1.4 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) ExoD PF06055.12 CDI79005.1 - 0.11 11.9 0.1 0.11 11.9 0.1 1.6 2 0 0 2 2 2 0 Exopolysaccharide synthesis, ExoD RAP1 PF07218.11 CDI79005.1 - 0.96 7.7 3.5 0.99 7.6 3.5 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Afi1 PF07792.12 CDI79005.1 - 7.2 7.1 29.8 2.9 8.4 13.2 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Prominin PF05478.11 CDI79059.1 - 4.6 5.1 12.8 1.8 6.4 9.5 1.8 2 0 0 2 2 2 0 Prominin Pkinase PF00069.25 CDI79061.1 - 1.6e-60 204.7 0.0 2.4e-60 204.1 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79061.1 - 1.9e-31 109.3 0.0 2.3e-31 109.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI79061.1 - 4.6e-07 29.4 0.0 8.7e-07 28.5 0.0 1.4 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CDI79061.1 - 0.021 14.5 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 CDI79061.1 - 0.15 12.0 0.0 1.5 8.7 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family RskA PF10099.9 CDI79070.1 - 0.18 12.1 11.0 20 5.4 10.7 2.6 2 1 0 2 2 2 0 Anti-sigma-K factor rskA CDC45 PF02724.14 CDI79093.1 - 0.00064 18.2 15.3 0.0008 17.8 15.3 1.2 1 0 0 1 1 1 1 CDC45-like protein RR_TM4-6 PF06459.12 CDI79093.1 - 0.0021 17.9 27.9 0.004 17.0 27.9 1.4 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 DUF2052 PF09747.9 CDI79093.1 - 0.004 17.3 21.2 0.0066 16.6 21.2 1.6 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) HCO3_cotransp PF00955.21 CDI79093.1 - 0.0085 15.0 4.8 0.012 14.5 4.8 1.2 1 0 0 1 1 1 1 HCO3- transporter family PRP1_N PF06424.12 CDI79093.1 - 0.016 15.6 21.6 0.029 14.8 21.6 1.5 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Tim54 PF11711.8 CDI79093.1 - 0.057 12.2 19.5 0.096 11.5 19.5 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Hamartin PF04388.12 CDI79093.1 - 0.13 10.9 25.2 0.17 10.5 25.2 1.2 1 0 0 1 1 1 0 Hamartin protein DUF4647 PF15504.6 CDI79093.1 - 0.19 10.8 22.9 0.25 10.4 22.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Cellulose_synt PF03552.14 CDI79093.1 - 0.21 10.1 9.1 0.26 9.7 9.1 1.1 1 0 0 1 1 1 0 Cellulose synthase ALMT PF11744.8 CDI79093.1 - 0.26 10.1 18.3 0.37 9.6 18.3 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter LMBR1 PF04791.16 CDI79093.1 - 0.27 10.1 8.8 0.33 9.8 8.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein PPP4R2 PF09184.11 CDI79093.1 - 0.28 10.7 20.2 0.4 10.2 20.2 1.3 1 0 0 1 1 1 0 PPP4R2 Hid1 PF12722.7 CDI79093.1 - 0.3 9.2 28.0 0.44 8.6 28.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SLC12 PF03522.15 CDI79093.1 - 0.33 9.9 27.5 0.46 9.4 27.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 LCD1 PF09798.9 CDI79093.1 - 1.2 7.6 21.4 1.5 7.2 21.4 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein GREB1 PF15782.5 CDI79093.1 - 1.2 6.1 30.3 1.5 5.8 30.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Paramyxo_ncap PF00973.19 CDI79093.1 - 1.2 7.9 19.5 1.7 7.5 19.5 1.4 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF2151 PF10221.9 CDI79093.1 - 2.8 6.4 18.5 3.9 5.9 18.5 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Rrn6 PF10214.9 CDI79093.1 - 2.9 6.3 34.8 3.5 6.0 34.8 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Smg8_Smg9 PF10220.9 CDI79093.1 - 3 6.0 24.8 3.7 5.7 24.8 1.2 1 0 0 1 1 1 0 Smg8_Smg9 VIR_N PF15912.5 CDI79093.1 - 4 7.0 17.0 5.4 6.5 17.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal SAPS PF04499.15 CDI79093.1 - 5.7 5.6 21.4 7.7 5.2 21.4 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein FNIP_N PF14636.6 CDI79093.1 - 8.4 7.3 28.4 0.48 11.4 20.2 2.4 2 0 0 2 2 2 0 Folliculin-interacting protein N-terminus Nop53 PF07767.11 CDI79093.1 - 9.9 5.4 38.2 0.021 14.2 27.4 2.0 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) DUF1180 PF06679.12 CDI79106.1 - 0.024 15.0 4.3 0.024 15.0 4.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1180) K_channel_TID PF07941.11 CDI79106.1 - 0.029 14.8 6.0 0.029 14.8 6.0 5.4 3 2 1 4 4 4 0 Potassium channel Kv1.4 tandem inactivation domain DUF2057 PF09829.9 CDI79106.1 - 0.27 11.4 2.6 0.48 10.6 2.6 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) LGFP PF08310.11 CDI79106.1 - 0.43 11.1 7.8 17 6.0 0.0 2.6 2 0 0 2 2 2 0 LGFP repeat DUF2967 PF11179.8 CDI79120.1 - 0.0014 16.8 9.5 0.0023 16.1 9.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2967) SprA-related PF12118.8 CDI79120.1 - 0.037 13.2 4.8 0.052 12.7 4.8 1.2 1 0 0 1 1 1 0 SprA-related family DUF3446 PF11928.8 CDI79120.1 - 0.039 14.3 15.3 0.065 13.6 9.7 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain KOW PF00467.29 CDI79120.1 - 0.068 13.1 0.6 0.11 12.5 0.6 1.3 1 0 0 1 1 1 0 KOW motif TFIIA PF03153.13 CDI79120.1 - 0.074 13.0 7.6 0.098 12.6 7.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI79120.1 - 1.5 7.6 3.2 1.9 7.1 3.2 1.1 1 0 0 1 1 1 0 Presenilin NDT80_PhoG PF05224.12 CDI79164.1 - 0.049 13.8 2.2 0.089 13.0 2.2 1.4 1 0 0 1 1 1 0 NDT80 / PhoG like DNA-binding family TFIIA PF03153.13 CDI79164.1 - 0.86 9.5 17.7 1.2 9.1 17.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GAS PF13851.6 CDI79166.1 - 0.0021 17.4 12.4 0.0021 17.4 12.4 4.6 4 1 0 4 4 4 3 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 CDI79166.1 - 0.0072 16.4 16.9 0.015 15.3 5.7 6.3 4 3 1 5 5 5 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cnn_1N PF07989.11 CDI79166.1 - 0.0089 16.2 6.3 0.0089 16.2 6.3 8.0 4 3 3 7 7 7 3 Centrosomin N-terminal motif 1 DUF2935 PF11155.8 CDI79166.1 - 0.012 15.9 17.9 0.43 10.9 1.2 4.4 4 1 0 4 4 4 0 Domain of unknown function (DUF2935) NPV_P10 PF05531.12 CDI79166.1 - 0.032 14.7 24.3 10 6.6 0.2 7.2 6 2 2 8 8 8 0 Nucleopolyhedrovirus P10 protein TMF_TATA_bd PF12325.8 CDI79166.1 - 1.3 9.3 85.5 0.45 10.8 4.8 7.1 4 3 3 7 7 7 0 TATA element modulatory factor 1 TATA binding TMV_coat PF00721.21 CDI79166.1 - 2.4 8.0 11.1 0.3 10.9 3.4 3.2 2 1 1 3 3 3 0 Virus coat protein (TMV like) EELM2 PF15863.5 CDI79168.1 - 1.7e-62 210.6 0.0 2.5e-62 210.0 0.0 1.3 1 0 0 1 1 1 1 Extended EGL-27 and MTA1 homology domain Pre-PUA PF17832.1 CDI79169.1 - 1.5e-26 92.9 0.0 2.3e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 CDI79169.1 - 5.9e-15 55.0 0.0 8.8e-15 54.4 0.0 1.3 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 CDI79169.1 - 0.02 15.2 0.0 0.035 14.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) Activator_LAG-3 PF11498.8 CDI79178.1 - 0.0025 16.8 32.9 0.0025 16.8 32.9 3.6 2 1 1 3 3 3 1 Transcriptional activator LAG-3 SUIM_assoc PF16619.5 CDI79184.1 - 0.0019 18.3 0.0 0.0019 18.3 0.0 8.3 5 3 1 6 6 6 2 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI79188.1 - 0.0038 16.9 5.4 0.0063 16.2 5.4 1.3 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 CDI79188.1 - 0.0057 16.7 15.8 0.0072 16.4 15.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Mucin PF01456.17 CDI79188.1 - 0.007 16.4 3.1 0.007 16.4 3.1 2.3 2 0 0 2 2 2 1 Mucin-like glycoprotein Activator_LAG-3 PF11498.8 CDI79188.1 - 0.0087 15.1 12.7 0.016 14.2 12.7 1.4 1 0 0 1 1 1 1 Transcriptional activator LAG-3 TGF_beta PF00019.20 CDI79188.1 - 0.016 16.2 0.8 0.053 14.5 0.1 2.1 2 0 0 2 2 2 0 Transforming growth factor beta like domain tRNA_synt_1c_R2 PF04557.15 CDI79188.1 - 0.064 14.2 0.2 0.064 14.2 0.2 2.1 2 1 1 3 3 3 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DUF1774 PF08611.10 CDI79188.1 - 0.31 11.4 3.5 0.29 11.5 0.3 2.1 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1774) DUF2722 PF10846.8 CDI79188.1 - 1 8.2 10.2 0.02 13.8 2.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) SCP_3 PF17844.1 CDI79189.1 - 0.039 13.7 1.0 0.14 11.9 0.6 2.3 2 0 0 2 2 2 0 Bacterial SCP ortholog DUF448 PF04296.13 CDI79189.1 - 2.2 8.2 7.0 2 8.3 0.6 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF448) Macoilin PF09726.9 CDI79195.1 - 2 6.9 20.4 2.4 6.6 20.4 1.1 1 0 0 1 1 1 0 Macoilin family Nop14 PF04147.12 CDI79220.1 - 0.0031 15.8 24.6 0.004 15.4 24.6 1.1 1 0 0 1 1 1 1 Nop14-like family Nop53 PF07767.11 CDI79220.1 - 0.0032 16.9 43.2 0.0039 16.7 43.2 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) RunxI PF08504.11 CDI79220.1 - 0.006 17.3 0.5 0.01 16.5 0.5 1.4 1 0 0 1 1 1 1 Runx inhibition domain XRCC4 PF06632.12 CDI79220.1 - 0.11 11.3 26.1 0.13 11.1 26.1 1.0 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 CDC45 PF02724.14 CDI79220.1 - 0.15 10.3 27.8 0.18 10.0 27.8 1.1 1 0 0 1 1 1 0 CDC45-like protein PP1_bind PF15276.6 CDI79220.1 - 0.33 11.3 4.9 0.31 11.4 3.2 1.8 1 1 1 2 2 2 0 Protein phosphatase 1 binding Orf78 PF06024.12 CDI79220.1 - 0.93 9.8 9.1 11 6.3 5.1 2.2 2 0 0 2 2 2 0 Orf78 (ac78) FYDLN_acid PF09538.10 CDI79220.1 - 1.5 9.5 26.1 0.9 10.3 13.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) CAC1F_C PF16885.5 CDI79220.1 - 1.8 8.2 16.1 2.5 7.7 16.1 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Prothymosin PF03247.14 CDI79220.1 - 3.6 8.1 43.9 1.2 9.7 32.5 2.1 2 0 0 2 2 2 0 Prothymosin/parathymosin family Pap_E4 PF02711.14 CDI79220.1 - 5.8 7.9 20.9 5.7 8.0 10.2 2.1 2 0 0 2 2 2 0 E4 protein DUF1387 PF07139.11 CDI79220.1 - 5.8 6.5 26.5 6.7 6.4 26.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Lin-8 PF03353.15 CDI79220.1 - 8 5.9 28.2 9.5 5.7 28.2 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist eRF1_3 PF03465.15 CDI79229.1 - 7.8e-05 23.1 1.1 7.8e-05 23.1 1.1 1.6 1 1 1 2 2 2 1 eRF1 domain 3 Presenilin PF01080.17 CDI79229.1 - 0.89 8.2 13.6 1 8.1 13.6 1.1 1 0 0 1 1 1 0 Presenilin PPP4R2 PF09184.11 CDI79229.1 - 1 8.9 13.2 1.3 8.5 13.2 1.1 1 0 0 1 1 1 0 PPP4R2 TFIIA PF03153.13 CDI79229.1 - 1.9 8.4 19.5 2.7 7.9 19.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM91_C PF14648.6 CDI79229.1 - 2.2 7.0 8.7 2.3 7.0 8.7 1.0 1 0 0 1 1 1 0 FAM91 C-terminus BES1_N PF05687.13 CDI79229.1 - 3.7 7.9 7.9 0.15 12.5 2.4 1.5 2 0 0 2 2 2 0 BES1/BZR1 plant transcription factor, N-terminal RepL PF05732.11 CDI79229.1 - 6.1 6.3 9.4 0.3 10.5 2.7 1.9 2 0 0 2 2 2 0 Firmicute plasmid replication protein (RepL) DUF5421 PF17458.2 CDI79229.1 - 8.4 5.7 17.3 0.061 12.7 3.5 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5421) Presenilin PF01080.17 CDI79232.1 - 0.047 12.5 40.0 0.05 12.4 40.0 1.0 1 0 0 1 1 1 0 Presenilin SelP_N PF04592.14 CDI79232.1 - 0.11 11.9 30.2 0.13 11.7 30.2 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RR_TM4-6 PF06459.12 CDI79232.1 - 1.4 8.7 37.3 1.5 8.6 37.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3295 PF11702.8 CDI79232.1 - 1.4 8.1 32.8 1.6 8.0 32.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Tmp39 PF10271.9 CDI79232.1 - 2.8 6.9 9.3 2.9 6.8 9.3 1.1 1 0 0 1 1 1 0 Putative transmembrane protein Velvet PF11754.8 CDI79232.1 - 3.4 7.5 32.4 4.2 7.2 32.4 1.2 1 0 0 1 1 1 0 Velvet factor Gti1_Pac2 PF09729.9 CDI79232.1 - 3.4 7.7 28.8 4.9 7.2 28.8 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4045 PF13254.6 CDI79232.1 - 5.1 6.6 30.9 5.2 6.6 30.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CDC45 PF02724.14 CDI79232.1 - 5.8 5.1 34.7 6.2 5.0 34.7 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF2052 PF09747.9 CDI79232.1 - 6.5 6.8 35.8 6.9 6.7 35.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) FAM60A PF15396.6 CDI79232.1 - 7.8 6.4 29.3 8.7 6.3 29.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Apt1 PF10351.9 CDI79232.1 - 7.9 5.2 27.2 9.1 5.0 27.2 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Spt20 PF12090.8 CDI79234.1 - 0.046 13.3 16.2 0.041 13.5 16.2 1.1 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 CDI79234.1 - 0.056 12.4 14.0 0.055 12.4 14.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Flavodoxin_NdrI PF07972.11 CDI79234.1 - 0.11 12.7 0.5 0.11 12.7 0.5 1.1 1 0 0 1 1 1 0 NrdI Flavodoxin like MAGE PF01454.19 CDI79234.1 - 0.12 12.1 6.4 0.12 12.1 6.4 1.0 1 0 0 1 1 1 0 MAGE family MecA PF05389.12 CDI79234.1 - 0.2 11.3 4.4 0.2 11.3 4.4 1.0 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Activator_LAG-3 PF11498.8 CDI79234.1 - 0.22 10.5 19.4 0.2 10.6 19.4 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF4834 PF16118.5 CDI79234.1 - 0.24 12.4 5.3 0.24 12.4 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Med15 PF09606.10 CDI79234.1 - 0.58 8.8 15.1 0.52 8.9 15.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Presenilin PF01080.17 CDI79234.1 - 0.77 8.5 4.1 0.69 8.6 4.1 1.1 1 0 0 1 1 1 0 Presenilin RAB3GAP2_N PF14655.6 CDI79234.1 - 0.78 8.9 5.3 0.85 8.8 5.3 1.0 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus TFIIA PF03153.13 CDI79234.1 - 0.99 9.3 17.2 0.97 9.4 17.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DivIC PF04977.15 CDI79234.1 - 1.5 8.6 10.8 1.7 8.5 10.8 1.3 1 0 0 1 1 1 0 Septum formation initiator Dpy19 PF10034.9 CDI79234.1 - 3.1 5.9 4.3 3.2 5.8 4.3 1.0 1 0 0 1 1 1 0 Q-cell neuroblast polarisation Roughex PF06020.11 CDI79234.1 - 5.7 5.9 11.2 6.2 5.8 11.2 1.1 1 0 0 1 1 1 0 Drosophila roughex protein PPS_PS PF02006.16 CDI79251.1 - 1.5 8.4 7.0 0.066 12.8 0.4 2.2 2 0 0 2 2 2 0 Phosphopantothenate/pantothenate synthetase Utp14 PF04615.13 CDI79252.1 - 0.7 8.4 37.2 0.97 7.9 37.2 1.1 1 0 0 1 1 1 0 Utp14 protein PAT1 PF09770.9 CDI79252.1 - 2.2 6.5 21.9 2.6 6.2 21.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4746 PF15928.5 CDI79252.1 - 2.6 7.4 13.5 3.8 6.8 13.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DDRGK PF09756.9 CDI79252.1 - 2.7 7.5 21.6 4.5 6.8 21.6 1.3 1 0 0 1 1 1 0 DDRGK domain TFIIA PF03153.13 CDI79252.1 - 9.8 6.0 44.2 3.8 7.4 39.4 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI79253.1 - 0.072 13.4 0.0 0.072 13.4 0.0 15.1 1 1 5 6 6 6 0 Anti-sigma-K factor rskA DUF3042 PF11240.8 CDI79253.1 - 0.16 12.0 0.1 0.16 12.0 0.1 5.1 4 2 1 5 5 5 0 Protein of unknown function (DUF3042) Syja_N PF02383.18 CDI79260.1 - 2.2e-15 56.8 14.5 4.6e-12 45.9 12.6 7.1 4 3 1 5 5 5 2 SacI homology domain DUF2722 PF10846.8 CDI79260.1 - 0.0041 16.1 5.6 0.0041 16.1 5.6 10.6 8 3 2 11 11 11 4 Protein of unknown function (DUF2722) MFS_1_like PF12832.7 CDI79260.1 - 0.076 11.9 0.0 0.45 9.3 0.1 2.2 1 1 1 2 2 2 0 MFS_1 like family MutS_V PF00488.21 CDI79314.1 - 1.8e-08 34.6 5.5 0.0023 18.0 0.0 3.3 4 0 0 4 4 4 2 MutS domain V Sporozoite_P67 PF05642.11 CDI79314.1 - 1.1e-07 30.4 10.6 1.1e-07 30.4 10.6 3.4 3 1 0 3 3 3 1 Sporozoite P67 surface antigen Mucin PF01456.17 CDI79314.1 - 0.011 15.8 4.0 0.011 15.8 4.0 5.1 4 1 1 5 5 5 0 Mucin-like glycoprotein RskA PF10099.9 CDI79324.1 - 2.7e-07 31.0 0.9 2.7e-07 31.0 0.9 9.1 3 2 3 7 7 7 3 Anti-sigma-K factor rskA RP-C_C PF11800.8 CDI79324.1 - 0.0056 16.8 17.6 0.0056 16.8 17.6 6.1 3 2 1 4 4 4 1 Replication protein C C-terminal region DUF1772 PF08592.11 CDI79324.1 - 0.19 12.0 0.1 0.19 12.0 0.1 6.4 4 1 1 6 6 6 0 Domain of unknown function (DUF1772) SIS PF01380.22 CDI79326.1 - 9.8e-36 122.5 0.5 5.3e-19 68.4 0.0 3.2 3 0 0 3 3 3 2 SIS domain GATase_6 PF13522.6 CDI79326.1 - 4.8e-20 72.1 0.0 1e-19 71.0 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CDI79326.1 - 2.8e-16 59.5 0.0 5.3e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 CDI79326.1 - 7.4e-05 21.8 0.1 0.00014 20.9 0.1 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II LRR_4 PF12799.7 CDI79329.1 - 5.5e-12 45.7 15.3 0.00068 20.0 0.4 3.6 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI79329.1 - 2.8e-07 30.2 12.0 0.00038 20.2 2.3 3.5 2 1 0 3 3 3 2 Leucine rich repeat LRR_9 PF14580.6 CDI79329.1 - 5.5e-05 22.7 2.5 0.00022 20.8 0.8 2.1 1 1 1 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.6 CDI79329.1 - 0.00058 19.7 12.5 3 8.1 0.0 5.4 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.33 CDI79329.1 - 0.00089 19.5 17.3 8 7.4 0.6 6.4 5 1 0 5 5 5 3 Leucine Rich Repeat SPATIAL PF15256.6 CDI79331.1 - 0.52 10.6 2.2 2 8.7 0.1 2.5 2 0 0 2 2 2 0 SPATIAL RskA PF10099.9 CDI79344.1 - 0.00093 19.5 7.2 0.00093 19.5 7.2 7.6 2 1 2 5 5 5 1 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI79346.1 - 0.021 13.6 33.6 0.023 13.4 33.6 1.1 1 0 0 1 1 1 0 Presenilin DUF2052 PF09747.9 CDI79346.1 - 0.049 13.8 29.4 0.058 13.5 29.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) O-antigen_lig PF13425.6 CDI79346.1 - 0.067 12.0 15.1 0.082 11.7 15.1 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Zip PF02535.22 CDI79346.1 - 0.15 11.2 18.6 0.18 11.0 18.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Suf PF05843.14 CDI79346.1 - 0.22 11.5 34.0 0.26 11.2 34.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MAPEG PF01124.18 CDI79346.1 - 0.39 10.6 0.0 0.39 10.6 0.0 2.0 1 1 1 2 2 1 0 MAPEG family CDC45 PF02724.14 CDI79346.1 - 0.63 8.3 29.5 0.74 8.0 29.5 1.0 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 CDI79346.1 - 0.67 9.7 30.5 0.92 9.3 30.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CCSAP PF15748.5 CDI79346.1 - 0.74 9.9 32.3 0.9 9.7 32.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 CDI79346.1 - 0.82 8.6 31.0 0.98 8.4 31.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 GAGA_bind PF06217.12 CDI79346.1 - 0.96 9.7 23.1 1.1 9.5 23.1 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family Hid1 PF12722.7 CDI79346.1 - 1.1 7.3 30.2 1.2 7.1 30.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PA26 PF04636.13 CDI79346.1 - 1.2 7.9 22.0 1.4 7.7 22.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4407 PF14362.6 CDI79346.1 - 1.2 8.4 29.3 1.7 7.9 29.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IML1 PF12257.8 CDI79346.1 - 1.2 8.1 12.6 1.4 7.9 12.6 1.1 1 0 0 1 1 1 0 Vacuolar membrane-associated protein Iml1 WTX PF09422.10 CDI79346.1 - 1.4 7.9 20.2 1.7 7.6 20.2 1.0 1 0 0 1 1 1 0 WTX protein Raftlin PF15250.6 CDI79346.1 - 2 7.1 24.0 2.3 6.9 24.0 1.0 1 0 0 1 1 1 0 Raftlin ALMT PF11744.8 CDI79346.1 - 2.6 6.8 23.8 3.1 6.5 23.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Auxin_canalis PF05703.11 CDI79346.1 - 3.2 7.6 16.4 3.8 7.4 16.4 1.1 1 0 0 1 1 1 0 Auxin canalisation Dicty_REP PF05086.12 CDI79346.1 - 4.5 5.1 21.5 5.7 4.8 21.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3357 PF11837.8 CDI79346.1 - 4.8 7.7 8.3 0.54 10.7 0.1 2.2 1 1 1 2 2 1 0 Domain of unknown function (DUF3357) XRN_M PF17846.1 CDI79346.1 - 5.3 5.9 25.6 6.2 5.7 25.6 1.0 1 0 0 1 1 1 0 Xrn1 helical domain NPR3 PF03666.13 CDI79346.1 - 6.8 5.4 29.7 8.5 5.0 29.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SAPS PF04499.15 CDI79346.1 - 7.5 5.2 25.1 8.9 5.0 25.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein K_trans PF02705.16 CDI79346.1 - 7.7 4.9 8.4 10 4.5 8.4 1.1 1 0 0 1 1 1 0 K+ potassium transporter G0-G1_switch_2 PF15103.6 CDI79346.1 - 7.7 7.0 30.6 0.12 12.8 7.6 2.2 1 1 1 2 2 1 0 G0/G1 switch protein 2 Sin_N PF04801.13 CDI79346.1 - 7.8 5.6 51.2 9.9 5.3 51.2 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region VIT1 PF01988.19 CDI79348.1 - 0.0017 18.2 10.7 0.0031 17.4 10.7 1.4 1 0 0 1 1 1 1 VIT family Lin-8 PF03353.15 CDI79348.1 - 0.0097 15.5 19.6 0.012 15.2 19.6 1.3 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 CDI79348.1 - 0.042 12.6 22.5 0.051 12.3 22.5 1.3 1 0 0 1 1 1 0 Presenilin BPL_N PF09825.9 CDI79348.1 - 0.069 12.2 11.5 0.076 12.1 11.5 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal V_ATPase_I PF01496.19 CDI79348.1 - 0.17 9.8 19.1 0.2 9.6 19.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Membralin PF09746.9 CDI79348.1 - 0.2 10.6 14.7 0.29 10.1 14.7 1.3 1 0 0 1 1 1 0 Tumour-associated protein CRT10 PF08728.10 CDI79348.1 - 0.22 9.7 10.8 0.24 9.6 10.8 1.0 1 0 0 1 1 1 0 CRT10 SOBP PF15279.6 CDI79348.1 - 0.45 11.1 23.4 0.6 10.7 23.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein RR_TM4-6 PF06459.12 CDI79348.1 - 0.63 9.8 23.3 1 9.1 23.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CCSAP PF15748.5 CDI79348.1 - 0.66 10.1 27.6 0.17 12.0 24.7 1.5 2 0 0 2 2 1 0 Centriole, cilia and spindle-associated Endostatin PF06482.11 CDI79348.1 - 0.67 9.4 19.1 0.83 9.1 19.1 1.4 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin MDM10 PF12519.8 CDI79348.1 - 1.1 8.1 16.2 1.2 7.9 16.2 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 FAM60A PF15396.6 CDI79348.1 - 1.2 9.1 17.6 2.1 8.3 17.6 1.5 1 0 0 1 1 1 0 Protein Family FAM60A HGTP_anticodon2 PF12745.7 CDI79348.1 - 1.2 8.6 21.5 2.1 7.8 21.5 1.4 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs DUF966 PF06136.13 CDI79348.1 - 1.6 8.4 18.0 1.8 8.2 18.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) GREB1 PF15782.5 CDI79348.1 - 1.7 5.7 23.6 1.6 5.7 23.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 CDI79348.1 - 2.6 7.0 25.8 3.5 6.5 25.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 TP53IP5 PF15331.6 CDI79348.1 - 2.6 8.1 19.2 4.2 7.4 19.2 1.4 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Neur_chan_memb PF02932.16 CDI79348.1 - 2.9 7.9 16.7 5.2 7.1 16.7 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI79348.1 - 3.1 6.5 20.3 3.8 6.2 20.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Draxin PF15550.6 CDI79348.1 - 3.5 7.4 17.1 4.1 7.2 17.1 1.1 1 0 0 1 1 1 0 Draxin PA26 PF04636.13 CDI79348.1 - 4.1 6.2 19.6 5.6 5.8 19.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) LMBR1 PF04791.16 CDI79348.1 - 6.5 5.5 11.9 8.2 5.2 11.9 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Hid1 PF12722.7 CDI79348.1 - 6.9 4.7 25.7 8.6 4.3 25.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GAGA_bind PF06217.12 CDI79348.1 - 7.2 6.8 21.7 11 6.2 21.7 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family DUF3584 PF12128.8 CDI79348.1 - 7.7 3.9 39.8 10 3.5 39.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF740 PF05340.12 CDI79348.1 - 9.3 4.9 12.5 14 4.3 12.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF740) TFIIA PF03153.13 CDI79351.1 - 0.00036 20.7 11.1 0.00045 20.3 11.1 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI79351.1 - 0.0019 17.0 5.3 0.0019 17.0 5.3 1.6 2 0 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal CR6_interact PF10147.9 CDI79351.1 - 0.0029 17.4 0.3 0.0029 17.4 0.3 2.0 2 0 0 2 2 2 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Spt20 PF12090.8 CDI79351.1 - 0.0063 16.2 14.0 0.0096 15.6 14.0 1.3 1 0 0 1 1 1 1 Spt20 family MRP-L28 PF09812.9 CDI79351.1 - 0.078 13.1 9.2 0.62 10.2 0.7 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L28 Rpp20 PF12328.8 CDI79351.1 - 0.084 12.8 3.6 6.3 6.8 1.1 2.2 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Roughex PF06020.11 CDI79351.1 - 0.17 11.0 6.1 0.25 10.4 6.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Androgen_recep PF02166.16 CDI79351.1 - 0.23 10.3 12.9 0.33 9.7 12.9 1.2 1 0 0 1 1 1 0 Androgen receptor DUF1840 PF08895.11 CDI79351.1 - 0.31 11.4 6.6 4.9 7.5 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Activator_LAG-3 PF11498.8 CDI79351.1 - 0.88 8.5 21.8 1.6 7.6 21.8 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 G0-G1_switch_2 PF15103.6 CDI79351.1 - 0.99 9.9 6.0 2.5 8.6 0.8 2.2 2 0 0 2 2 2 0 G0/G1 switch protein 2 DUF4834 PF16118.5 CDI79351.1 - 9.4 7.3 8.7 0.81 10.7 3.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) UPF0560 PF10577.9 CDI79351.1 - 10 4.5 10.5 1.3 7.4 6.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 KH_9 PF17904.1 CDI79359.1 - 1.5 9.2 7.5 3.7 8.0 0.3 3.3 2 1 1 3 3 3 0 FMRP KH0 domain ABC2_membrane_3 PF12698.7 CDI79359.1 - 4.6 6.3 5.5 10 5.1 5.5 1.7 1 0 0 1 1 1 0 ABC-2 family transporter protein RskA PF10099.9 CDI79364.1 - 0.00032 21.0 6.3 0.00032 21.0 6.3 7.5 3 1 3 6 6 6 3 Anti-sigma-K factor rskA Ribosomal_60s PF00428.19 CDI79364.1 - 0.0045 17.6 11.4 0.0045 17.6 11.4 10.0 4 2 2 6 6 6 1 60s Acidic ribosomal protein DUF3915 PF13054.6 CDI79364.1 - 0.01 15.8 1.1 0.31 11.0 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Band_7 PF01145.25 CDI79369.1 - 0.0068 16.4 2.1 0.0092 16.0 2.1 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF4666 PF15697.5 CDI79369.1 - 0.1 13.3 0.1 0.1 13.3 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4666) Spt20 PF12090.8 CDI79369.1 - 0.62 9.6 15.1 0.81 9.3 15.1 1.2 1 0 0 1 1 1 0 Spt20 family Suf PF05843.14 CDI79375.1 - 0.0073 16.3 7.3 0.0073 16.3 7.3 5.1 4 1 0 4 4 4 1 Suppressor of forked protein (Suf) La PF05383.17 CDI79384.1 - 7.3e-08 32.4 0.2 1.3e-07 31.5 0.2 1.4 1 0 0 1 1 1 1 La domain AAA_23 PF13476.6 CDI79384.1 - 0.0053 17.3 27.9 0.0067 16.9 27.9 1.1 1 0 0 1 1 1 1 AAA domain Hamartin PF04388.12 CDI79384.1 - 4.9 5.7 48.7 5.7 5.5 48.7 1.0 1 0 0 1 1 1 0 Hamartin protein FapA PF03961.13 CDI79384.1 - 6.6 5.2 20.2 11 4.5 20.2 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A CDC45 PF02724.14 CDI79395.1 - 0.19 10.0 8.8 0.25 9.6 8.8 1.3 1 0 0 1 1 1 0 CDC45-like protein SGT1 PF07093.11 CDI79395.1 - 0.31 9.5 6.1 0.46 8.9 6.1 1.2 1 0 0 1 1 1 0 SGT1 protein CPSF100_C PF13299.6 CDI79395.1 - 6.8 6.8 7.8 0.83 9.8 2.1 2.2 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Nop14 PF04147.12 CDI79395.1 - 8.1 4.5 15.2 12 4.0 15.2 1.3 1 0 0 1 1 1 0 Nop14-like family RNA_pol_Rpc4 PF05132.14 CDI79395.1 - 8.1 6.9 7.1 4.4 7.7 1.9 2.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 FAM176 PF14851.6 CDI79396.1 - 0.077 12.7 1.7 0.85 9.3 0.2 2.7 2 0 0 2 2 2 0 FAM176 family Molybdopterin_N PF18364.1 CDI79396.1 - 0.097 12.7 0.1 0.22 11.5 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin oxidoreductase N-terminal domain PNK3P PF08645.11 CDI79397.1 - 3.3e-33 114.7 0.0 2.6e-21 76.0 0.0 2.4 2 0 0 2 2 2 2 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 CDI79397.1 - 1.4e-09 38.3 0.1 9.1e-07 29.1 0.1 2.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDI79397.1 - 7.9e-06 26.4 0.2 4.1e-05 24.0 0.1 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CDI79397.1 - 3.3e-05 24.2 0.0 6.6e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain tRNA_lig_kinase PF08303.11 CDI79397.1 - 3.7e-05 23.9 0.0 5.9e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 tRNA ligase kinase domain Zeta_toxin PF06414.12 CDI79397.1 - 0.00027 20.3 0.3 0.062 12.6 0.1 2.4 1 1 1 2 2 2 1 Zeta toxin RsgA_GTPase PF03193.16 CDI79397.1 - 0.00063 19.7 0.1 0.0012 18.7 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase G-alpha PF00503.20 CDI79397.1 - 0.0019 17.5 0.1 0.0028 16.9 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit AAA_18 PF13238.6 CDI79397.1 - 0.0035 17.9 0.1 0.011 16.3 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CDI79397.1 - 0.0055 17.0 0.0 0.012 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDI79397.1 - 0.007 16.1 0.0 0.019 14.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain 6PF2K PF01591.18 CDI79397.1 - 0.0077 15.6 0.2 3.3 7.0 0.0 2.5 1 1 1 2 2 2 1 6-phosphofructo-2-kinase AAA_5 PF07728.14 CDI79397.1 - 0.01 15.8 0.1 0.034 14.1 0.1 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.23 CDI79397.1 - 0.014 15.4 0.0 0.039 14.0 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.12 CDI79397.1 - 0.018 14.9 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 CDI79397.1 - 0.02 15.4 0.0 0.048 14.2 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_19 PF13245.6 CDI79397.1 - 0.027 14.8 0.0 0.055 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 CDI79397.1 - 0.031 13.7 1.1 0.4 10.1 0.1 2.2 1 1 1 2 2 2 0 Chromatin associated protein KTI12 Mg_chelatase PF01078.21 CDI79397.1 - 0.036 13.5 0.0 0.17 11.2 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Ploopntkinase3 PF18751.1 CDI79397.1 - 0.05 13.5 0.0 0.085 12.8 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 MeaB PF03308.16 CDI79397.1 - 0.051 12.6 0.0 0.11 11.4 0.0 1.6 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 CDI79397.1 - 0.06 12.5 0.0 0.097 11.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_10 PF12846.7 CDI79397.1 - 0.071 12.0 0.0 0.16 10.9 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain cobW PF02492.19 CDI79397.1 - 0.075 12.6 0.7 0.33 10.5 0.0 2.4 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 CDI79397.1 - 0.1 13.0 0.0 0.45 10.9 0.0 2.1 2 0 0 2 2 1 0 RNA helicase FtsK_SpoIIIE PF01580.18 CDI79397.1 - 0.15 11.4 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_17 PF13207.6 CDI79397.1 - 0.16 12.4 0.9 1.9 8.9 0.1 2.8 2 1 1 3 3 3 0 AAA domain V-ATPase_G PF03179.15 CDI79398.1 - 5.7e-09 36.4 12.2 1.3e-08 35.3 12.2 1.6 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit V-ATPase_G_2 PF16999.5 CDI79398.1 - 0.046 14.1 15.2 0.2 12.1 15.2 2.1 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Trp_oprn_chp PF09534.10 CDI79416.1 - 0.006 16.4 20.0 0.006 16.4 20.0 1.5 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3995 PF13160.6 CDI79416.1 - 0.017 15.5 11.4 0.71 10.2 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3995) RskA PF10099.9 CDI79416.1 - 0.026 14.8 34.2 0.017 15.4 13.3 2.7 1 1 1 2 2 2 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI79416.1 - 0.096 12.7 29.3 0.12 12.3 29.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4056 PF13265.6 CDI79416.1 - 0.76 9.0 6.8 0.34 10.2 3.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4056) DUF3381 PF11861.8 CDI79416.1 - 1.7 8.4 14.2 3.5 7.4 14.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Mucin PF01456.17 CDI79429.1 - 0.004 17.1 26.4 0.0049 16.9 26.4 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF3439 PF11921.8 CDI79429.1 - 0.014 15.4 11.1 0.017 15.1 11.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 CDI79429.1 - 0.12 10.3 4.7 0.12 10.4 4.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 CDI79429.1 - 0.38 8.9 23.7 0.42 8.8 23.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Tir_receptor_C PF07489.11 CDI79429.1 - 1.1 9.2 15.6 1.3 8.9 15.6 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus RIFIN PF02009.16 CDI79429.1 - 2.3 8.1 8.2 3.2 7.5 8.2 1.3 1 0 0 1 1 1 0 Rifin RskA PF10099.9 CDI79436.1 - 0.002 18.4 10.1 0.002 18.4 10.1 2.1 1 1 1 2 2 2 1 Anti-sigma-K factor rskA SID-1_RNA_chan PF13965.6 CDI79436.1 - 0.022 13.2 5.9 0.029 12.8 5.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 CDI79436.1 - 0.26 10.3 11.9 0.32 10.0 11.9 1.3 1 0 0 1 1 1 0 Solute carrier family 12 PMSI1 PF15322.6 CDI79436.1 - 0.37 10.2 21.0 0.57 9.6 21.0 1.2 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative TFIIA PF03153.13 CDI79436.1 - 0.43 10.5 30.4 0.51 10.3 30.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI79436.1 - 0.61 8.6 23.5 0.86 8.1 23.5 1.2 1 0 0 1 1 1 0 Macoilin family DUF2052 PF09747.9 CDI79436.1 - 0.69 10.0 9.7 0.86 9.7 9.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RIFIN PF02009.16 CDI79436.1 - 0.77 9.6 20.3 0.98 9.2 20.3 1.1 1 0 0 1 1 1 0 Rifin CytochromB561_N PF09786.9 CDI79436.1 - 1.4 7.8 19.6 1.5 7.7 19.6 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal SWI-SNF_Ssr4 PF08549.10 CDI79436.1 - 2.2 6.8 27.4 2.7 6.5 27.4 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) CDC27 PF09507.10 CDI79436.1 - 2.7 7.3 22.7 4 6.7 22.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PAT1 PF09770.9 CDI79436.1 - 9.1 4.4 20.7 11 4.1 20.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SR-25 PF10500.9 CDI79445.1 - 0.0021 17.7 14.9 0.0021 17.7 14.9 4.2 2 2 2 4 4 4 1 Nuclear RNA-splicing-associated protein N6_N4_Mtase PF01555.18 CDI79445.1 - 0.19 11.4 18.5 0.68 9.6 0.0 4.1 1 1 2 3 3 3 0 DNA methylase RskA PF10099.9 CDI79453.1 - 0.0027 18.0 4.0 0.0027 18.0 4.0 4.1 1 1 1 4 4 4 2 Anti-sigma-K factor rskA DotU PF09850.9 CDI79453.1 - 0.019 14.7 1.5 0.019 14.7 1.5 3.0 4 0 0 4 4 4 0 Type VI secretion system protein DotU AdoMet_Synthase PF01941.19 CDI79453.1 - 0.18 10.6 0.1 0.27 10.0 0.1 1.2 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) NINJA_B PF16136.5 CDI79453.1 - 0.24 11.8 16.6 0.36 11.2 0.7 3.7 3 1 0 3 3 3 0 Putative nuclear localisation signal FHIPEP PF00771.20 CDI79453.1 - 1.7 7.0 4.7 1.6 7.1 0.8 2.1 2 0 0 2 2 2 0 FHIPEP family OATP PF03137.20 CDI79453.1 - 1.9 6.7 7.7 0.047 12.0 0.4 1.9 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Connexin PF00029.19 CDI79453.1 - 3.1 7.5 7.0 0.89 9.3 1.4 2.6 4 0 0 4 4 4 0 Connexin Rxt3 PF08642.10 CDI79458.1 - 0.00041 21.1 6.2 0.075 13.8 0.2 2.4 2 0 0 2 2 2 2 Histone deacetylation protein Rxt3 eIF-3_zeta PF05091.12 CDI79458.1 - 0.016 14.2 14.6 0.099 11.6 7.6 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MMR1 PF08505.10 CDI79458.1 - 0.02 15.2 19.2 0.026 14.8 9.1 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Peptidase_S49_N PF08496.10 CDI79458.1 - 0.066 13.3 13.3 0.26 11.3 2.8 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Peroxin-13_N PF04088.13 CDI79458.1 - 0.1 12.9 7.8 0.16 12.2 1.2 2.4 2 0 0 2 2 2 0 Peroxin 13, N-terminal region MecA PF05389.12 CDI79458.1 - 0.23 11.0 10.8 0.65 9.6 4.4 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) Pal1 PF08316.11 CDI79458.1 - 0.36 11.6 5.6 0.57 10.9 1.2 2.6 2 0 0 2 2 2 0 Pal1 cell morphology protein PH_4 PF15404.6 CDI79458.1 - 0.39 10.5 9.4 1.2 9.0 3.8 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain SpoIIP PF07454.11 CDI79458.1 - 0.48 9.8 13.4 0.21 11.0 4.9 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) FAM91_C PF14648.6 CDI79458.1 - 0.59 8.9 7.1 0.14 11.0 2.3 1.9 2 0 0 2 2 2 0 FAM91 C-terminus Methyltransf_23 PF13489.6 CDI79458.1 - 0.9 9.4 5.2 1.2 9.0 1.1 2.3 2 0 0 2 2 2 0 Methyltransferase domain SLC12 PF03522.15 CDI79458.1 - 2.2 7.2 13.5 0.79 8.7 7.0 2.0 2 0 0 2 2 2 0 Solute carrier family 12 Tim54 PF11711.8 CDI79458.1 - 2.6 6.7 11.0 0.34 9.6 1.6 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 FHIPEP PF00771.20 CDI79458.1 - 2.7 6.4 12.5 0.67 8.4 5.1 2.2 2 0 0 2 2 2 0 FHIPEP family DUF1115 PF06544.12 CDI79458.1 - 2.8 8.0 9.7 0.79 9.8 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1115) Connexin PF00029.19 CDI79458.1 - 3 7.5 9.7 2.9 7.6 3.6 2.3 2 0 0 2 2 2 0 Connexin DUF4834 PF16118.5 CDI79458.1 - 3.3 8.7 27.1 2.1 9.4 2.2 2.6 3 0 0 3 3 2 0 Domain of unknown function (DUF4834) RPA43_OB PF17875.1 CDI79458.1 - 3.4 8.3 11.1 1.6 9.4 2.7 2.4 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I AIF_C PF14721.6 CDI79458.1 - 3.6 7.9 12.6 5.9 7.3 4.6 2.7 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Thg1C PF14413.6 CDI79458.1 - 3.8 7.7 14.3 4.8 7.4 6.7 2.6 3 0 0 3 3 3 0 Thg1 C terminal domain EIIBC-GUT_N PF03612.14 CDI79458.1 - 4 7.1 15.1 0.49 10.1 4.8 2.5 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Folliculin PF11704.8 CDI79458.1 - 7.5 6.4 10.7 7.9 6.3 5.4 2.4 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF3537 PF12056.8 CDI79458.1 - 8 5.2 8.6 6.8 5.4 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3537) Tau95_N PF17682.1 CDI79458.1 - 8.8 6.5 10.7 5.5 7.2 2.6 2.5 3 0 0 3 3 2 0 Tau95 Triple barrel domain DUF913 PF06025.12 CDI79459.1 - 1.4 7.8 21.2 1.5 7.7 21.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Pex14_N PF04695.13 CDI79459.1 - 1.8 9.2 45.8 2.8 8.6 45.8 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Gti1_Pac2 PF09729.9 CDI79459.1 - 4.8 7.2 29.7 5.7 7.0 29.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF2828 PF11443.8 CDI79459.1 - 5.5 4.9 31.9 6.3 4.8 31.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF3807 PF12720.7 CDI79459.1 - 5.7 7.2 42.7 7 6.9 42.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Presenilin PF01080.17 CDI79459.1 - 6.1 5.5 43.9 6.6 5.4 43.9 1.0 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI79459.1 - 6.8 6.6 28.8 7.6 6.5 28.8 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Rtf2 PF04641.12 CDI79459.1 - 7.7 5.8 30.7 8.3 5.7 30.7 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF4746 PF15928.5 CDI79459.1 - 8.5 5.7 26.9 10 5.5 26.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) NPR3 PF03666.13 CDI79459.1 - 8.7 5.0 37.2 10 4.8 37.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CobT PF06213.12 CDI79459.1 - 9.5 5.5 47.2 13 5.1 47.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3295 PF11702.8 CDI79459.1 - 9.9 5.4 32.6 11 5.2 32.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Mucin PF01456.17 CDI79461.1 - 0.0011 18.9 9.5 0.0011 18.9 9.5 1.7 2 0 0 2 2 2 1 Mucin-like glycoprotein HCO3_cotransp PF00955.21 CDI79461.1 - 2.3 6.9 5.1 3.7 6.3 5.1 1.3 1 0 0 1 1 1 0 HCO3- transporter family Cellulose_synt PF03552.14 CDI79461.1 - 6.6 5.1 6.2 9.2 4.6 6.2 1.2 1 0 0 1 1 1 0 Cellulose synthase DUF4820 PF16091.5 CDI79463.1 - 2.3 7.5 31.7 2.7 7.3 31.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) GDI PF00996.18 CDI79465.1 - 1.9e-12 46.4 0.0 6.2e-08 31.6 0.0 3.0 3 0 0 3 3 3 2 GDP dissociation inhibitor G0-G1_switch_2 PF15103.6 CDI79465.1 - 0.01 16.3 3.7 0.01 16.3 3.7 10.2 10 1 0 10 10 10 0 G0/G1 switch protein 2 Adaptin_binding PF10199.9 CDI79465.1 - 0.065 13.8 0.0 0.065 13.8 0.0 9.6 6 3 1 7 7 7 0 Alpha and gamma adaptin binding protein p34 Utp14 PF04615.13 CDI79466.1 - 6.1e-08 31.7 0.0 6.1e-08 31.7 0.0 9.3 2 2 6 8 8 8 1 Utp14 protein Activator_LAG-3 PF11498.8 CDI79466.1 - 0.0018 17.4 45.9 0.0018 17.4 45.9 15.2 8 3 8 16 16 16 1 Transcriptional activator LAG-3 WD40 PF00400.32 CDI79478.1 - 0.00012 22.8 8.4 3.7 8.6 0.0 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI79478.1 - 0.015 15.5 0.0 11 6.4 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain YABBY PF04690.13 CDI79484.1 - 0.46 11.0 9.2 0.31 11.6 7.7 1.4 1 1 0 1 1 1 0 YABBY protein TFIIA PF03153.13 CDI79484.1 - 1 9.3 30.1 1.6 8.7 30.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI79484.1 - 1.9 8.5 8.3 2.5 8.1 8.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Draxin PF15550.6 CDI79484.1 - 2.1 8.2 17.1 3 7.6 17.1 1.2 1 0 0 1 1 1 0 Draxin SpoIIP PF07454.11 CDI79484.1 - 5.7 6.3 13.6 8.9 5.7 13.6 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TFIIA PF03153.13 CDI79486.1 - 3.2e-07 30.7 75.8 0.00027 21.1 27.5 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI79486.1 - 6.9e-06 26.4 21.7 0.0006 20.0 6.6 2.3 2 0 0 2 2 2 2 DDHD domain NPR3 PF03666.13 CDI79486.1 - 0.00014 20.8 26.2 0.021 13.7 3.2 2.2 2 0 0 2 2 2 2 Nitrogen Permease regulator of amino acid transport activity 3 SpoIIP PF07454.11 CDI79486.1 - 0.00021 20.8 29.8 0.025 14.0 16.9 2.2 2 0 0 2 2 2 2 Stage II sporulation protein P (SpoIIP) DUF2722 PF10846.8 CDI79486.1 - 0.00099 18.2 18.2 0.00099 18.2 18.2 3.2 2 1 1 3 3 1 1 Protein of unknown function (DUF2722) Velvet PF11754.8 CDI79486.1 - 0.0011 19.0 28.1 0.061 13.2 11.6 2.2 2 0 0 2 2 2 2 Velvet factor EPL1 PF10513.9 CDI79486.1 - 0.0011 19.3 31.2 0.087 13.2 18.0 2.4 2 0 0 2 2 2 2 Enhancer of polycomb-like FAM76 PF16046.5 CDI79486.1 - 0.0013 18.2 28.8 0.045 13.1 16.3 2.2 2 0 0 2 2 2 2 FAM76 protein Presenilin PF01080.17 CDI79486.1 - 0.0014 17.5 37.6 0.054 12.3 18.4 2.1 2 0 0 2 2 2 2 Presenilin PNISR PF15996.5 CDI79486.1 - 0.0021 18.4 33.1 0.035 14.4 16.2 2.4 2 0 0 2 2 2 2 Arginine/serine-rich protein PNISR NARP1 PF12569.8 CDI79486.1 - 0.0029 16.6 37.0 0.055 12.4 17.6 2.2 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 DUF4471 PF14740.6 CDI79486.1 - 0.0035 16.6 16.0 0.14 11.3 8.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4471) BORG_CEP PF14957.6 CDI79486.1 - 0.0036 18.5 19.7 0.23 12.6 7.9 2.5 2 0 0 2 2 2 2 Cdc42 effector CCSAP PF15748.5 CDI79486.1 - 0.0037 17.5 35.5 0.14 12.3 10.2 2.2 2 0 0 2 2 2 2 Centriole, cilia and spindle-associated Otopetrin PF03189.13 CDI79486.1 - 0.0041 16.0 9.6 0.023 13.5 1.8 2.1 2 0 0 2 2 2 2 Otopetrin FmiP_Thoc5 PF09766.9 CDI79486.1 - 0.0099 15.2 41.4 0.26 10.5 9.1 2.2 2 0 0 2 2 2 2 Fms-interacting protein/Thoc5 DUF2052 PF09747.9 CDI79486.1 - 0.01 16.0 30.4 0.15 12.2 15.7 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) NST1 PF13945.6 CDI79486.1 - 0.011 15.9 36.9 0.28 11.3 21.1 2.4 2 0 0 2 2 2 0 Salt tolerance down-regulator DUF2126 PF09899.9 CDI79486.1 - 0.012 13.7 22.3 0.055 11.5 7.7 2.3 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) Isy1 PF06246.12 CDI79486.1 - 0.017 14.7 27.5 0.1 12.1 3.2 2.3 2 0 0 2 2 2 0 Isy1-like splicing family RXT2_N PF08595.11 CDI79486.1 - 0.023 14.7 15.9 0.25 11.3 6.2 2.5 2 0 0 2 2 2 0 RXT2-like, N-terminal PAT1 PF09770.9 CDI79486.1 - 0.025 12.9 58.4 0.16 10.3 19.7 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SAGA-Tad1 PF12767.7 CDI79486.1 - 0.029 14.1 26.0 0.099 12.4 6.3 2.2 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit SAPS PF04499.15 CDI79486.1 - 0.031 13.1 25.5 0.03 13.1 4.8 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Serinc PF03348.15 CDI79486.1 - 0.036 13.0 19.1 0.039 12.9 7.6 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) Raftlin PF15250.6 CDI79486.1 - 0.043 12.6 24.7 0.052 12.3 4.9 2.1 2 0 0 2 2 2 0 Raftlin Connexin PF00029.19 CDI79486.1 - 0.045 13.5 27.9 0.12 12.1 3.2 2.2 2 0 0 2 2 2 0 Connexin Neur_chan_memb PF02932.16 CDI79486.1 - 0.067 13.2 27.8 0.28 11.2 6.3 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Hamartin PF04388.12 CDI79486.1 - 0.069 11.8 31.6 0.049 12.3 9.5 2.1 2 0 0 2 2 2 0 Hamartin protein SLC12 PF03522.15 CDI79486.1 - 0.078 12.0 32.0 0.4 9.7 17.0 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Tim54 PF11711.8 CDI79486.1 - 0.079 11.7 29.9 0.3 9.8 14.4 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 YTH PF04146.15 CDI79486.1 - 0.08 12.9 11.3 0.087 12.8 1.9 2.3 2 0 0 2 2 2 0 YT521-B-like domain ABC2_membrane_2 PF12679.7 CDI79486.1 - 0.083 12.2 11.2 0.14 11.4 1.4 2.3 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF4045 PF13254.6 CDI79486.1 - 0.095 12.3 30.4 0.73 9.4 9.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) HNOBA PF07701.14 CDI79486.1 - 0.097 12.1 21.7 0.48 9.8 9.1 2.5 2 0 0 2 2 2 0 Heme NO binding associated Lin-8 PF03353.15 CDI79486.1 - 0.1 12.1 36.9 0.89 9.0 7.6 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 CDI79486.1 - 0.11 10.7 26.1 0.28 9.4 12.7 2.1 2 0 0 2 2 2 0 CDC45-like protein SPX PF03105.19 CDI79486.1 - 0.12 12.3 23.6 0.52 10.2 8.6 2.1 2 0 0 2 2 2 0 SPX domain AUX_IAA PF02309.16 CDI79486.1 - 0.14 12.0 18.0 1.1 9.1 3.3 2.5 2 0 0 2 2 2 0 AUX/IAA family CTNNB1_binding PF08347.11 CDI79486.1 - 0.15 12.3 24.0 4.9 7.3 4.4 3.3 3 0 0 3 3 3 0 N-terminal CTNNB1 binding CNDH2_C PF16858.5 CDI79486.1 - 0.18 11.6 33.2 1 9.1 7.6 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Caldesmon PF02029.15 CDI79486.1 - 0.19 10.5 33.9 0.38 9.5 7.4 2.1 2 0 0 2 2 2 0 Caldesmon GREB1 PF15782.5 CDI79486.1 - 0.22 8.6 32.3 0.029 11.5 6.7 2.1 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer AAR2 PF05282.11 CDI79486.1 - 0.22 10.9 19.5 0.53 9.6 1.9 2.2 2 0 0 2 2 2 0 AAR2 protein DUF4770 PF15994.5 CDI79486.1 - 0.22 11.7 36.7 1.2 9.3 9.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Gti1_Pac2 PF09729.9 CDI79486.1 - 0.23 11.5 31.1 0.44 10.6 5.5 2.3 2 0 0 2 2 2 0 Gti1/Pac2 family CPSF100_C PF13299.6 CDI79486.1 - 0.23 11.6 32.5 1.5 9.0 7.8 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal XAP5 PF04921.14 CDI79486.1 - 0.23 11.2 20.4 1.4 8.7 10.0 2.3 2 0 0 2 2 2 0 XAP5, circadian clock regulator AF-4 PF05110.13 CDI79486.1 - 0.25 9.4 43.1 0.66 8.0 20.6 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein EOS1 PF12326.8 CDI79486.1 - 0.26 11.2 19.6 0.34 10.8 0.4 2.3 2 0 0 2 2 2 0 N-glycosylation protein MDM10 PF12519.8 CDI79486.1 - 0.28 10.0 25.1 0.48 9.2 12.4 2.1 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 SOBP PF15279.6 CDI79486.1 - 0.3 11.7 36.2 1.7 9.2 14.5 2.1 2 0 0 2 2 2 0 Sine oculis-binding protein Endostatin PF06482.11 CDI79486.1 - 0.32 10.4 40.3 0.069 12.6 11.9 2.1 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin DUF4518 PF15008.6 CDI79486.1 - 0.33 10.1 29.8 0.099 11.8 4.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) Ndc1_Nup PF09531.10 CDI79486.1 - 0.34 9.5 34.3 0.96 8.1 14.2 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup SRP-alpha_N PF04086.13 CDI79486.1 - 0.35 10.8 30.0 0.45 10.4 12.7 2.2 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Peptidase_S64 PF08192.11 CDI79486.1 - 0.39 9.1 25.9 0.95 7.9 13.6 2.1 2 0 0 2 2 2 0 Peptidase family S64 DUF572 PF04502.13 CDI79486.1 - 0.4 10.2 34.8 0.077 12.6 7.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) DUF4050 PF13259.6 CDI79486.1 - 0.46 10.8 30.7 1.8 8.8 14.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) Slu7 PF11708.8 CDI79486.1 - 0.5 10.1 32.5 0.38 10.5 4.7 2.3 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor MMR1 PF08505.10 CDI79486.1 - 0.53 10.5 40.6 2.7 8.2 11.3 2.3 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein DUF5523 PF17661.1 CDI79486.1 - 0.57 9.8 36.5 0.28 10.9 6.9 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Pex14_N PF04695.13 CDI79486.1 - 0.6 10.7 68.9 0.067 13.8 28.1 2.8 2 1 1 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region LTV PF04180.14 CDI79486.1 - 0.63 9.7 27.0 1.4 8.6 4.6 2.1 2 0 0 2 2 2 0 Low temperature viability protein DUF4638 PF15472.6 CDI79486.1 - 0.74 9.5 29.1 1.1 8.9 15.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) DDRGK PF09756.9 CDI79486.1 - 0.78 9.3 49.2 0.47 10.0 27.4 2.3 2 0 0 2 2 2 0 DDRGK domain DAG_kinase_N PF14513.6 CDI79486.1 - 0.79 9.9 29.8 1.9 8.7 5.3 2.4 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus DUF2464 PF10240.9 CDI79486.1 - 0.82 9.2 22.0 0.32 10.5 2.5 2.2 2 0 0 2 2 2 0 Multivesicular body subunit 12 Membralin PF09746.9 CDI79486.1 - 0.88 8.5 20.9 1.7 7.6 11.9 2.2 2 0 0 2 2 2 0 Tumour-associated protein RPOL_N PF14700.6 CDI79486.1 - 0.89 8.9 36.5 0.41 10.0 5.8 2.6 3 0 0 3 3 2 0 DNA-directed RNA polymerase N-terminal Pkinase_fungal PF17667.1 CDI79486.1 - 0.9 8.2 19.1 0.98 8.1 8.4 2.1 2 0 0 2 2 2 0 Fungal protein kinase DUF4746 PF15928.5 CDI79486.1 - 1.1 8.7 25.2 1.3 8.4 2.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Nha1_C PF08619.10 CDI79486.1 - 1.1 8.4 35.2 0.74 9.0 14.3 2.1 2 0 0 2 2 2 0 Alkali metal cation/H+ antiporter Nha1 C terminus eIF-3_zeta PF05091.12 CDI79486.1 - 1.2 8.1 48.9 1.9 7.4 14.2 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Sec62 PF03839.16 CDI79486.1 - 1.3 8.5 27.1 0.79 9.2 12.6 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 SMYLE_N PF18615.1 CDI79486.1 - 1.5 8.3 26.0 1.2 8.7 7.3 2.2 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain GT87 PF09594.10 CDI79486.1 - 1.5 8.5 13.8 11 5.7 8.1 2.7 1 1 1 2 2 2 0 Glycosyltransferase family 87 Pinin_SDK_memA PF04696.13 CDI79486.1 - 1.5 8.8 58.0 0.64 10.1 13.2 2.5 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region MRP-S31 PF15433.6 CDI79486.1 - 1.6 8.4 32.2 1.7 8.2 16.5 2.3 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 Afi1 PF07792.12 CDI79486.1 - 1.6 9.2 33.3 0.55 10.7 4.3 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF1644 PF07800.12 CDI79486.1 - 1.7 8.7 20.2 4.4 7.3 8.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) Band_3_cyto PF07565.13 CDI79486.1 - 1.7 8.4 33.6 0.064 13.1 2.2 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF913 PF06025.12 CDI79486.1 - 1.7 7.5 26.2 0.87 8.5 3.9 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF5308 PF17233.2 CDI79486.1 - 1.8 8.8 37.9 0.023 14.9 8.4 2.7 2 1 0 2 2 1 0 Family of unknown function (DUF5308) BSMAP PF12280.8 CDI79486.1 - 1.9 8.6 25.2 0.71 10.1 3.8 2.5 2 0 0 2 2 2 0 Brain specific membrane anchored protein TT_ORF1 PF02956.14 CDI79486.1 - 2.2 6.8 21.9 2.7 6.5 2.1 2.1 2 0 0 2 2 2 0 TT viral orf 1 Zip PF02535.22 CDI79486.1 - 2.4 7.3 21.6 0.12 11.5 2.5 2.3 2 1 0 2 2 2 0 ZIP Zinc transporter Dynamin_N PF00350.23 CDI79486.1 - 2.6 8.1 16.2 4.7 7.3 0.9 2.3 2 0 0 2 2 2 0 Dynamin family CLN3 PF02487.17 CDI79486.1 - 2.8 6.9 28.1 3.8 6.5 4.9 2.3 2 0 0 2 2 2 0 CLN3 protein GPCR_chapero_1 PF11904.8 CDI79486.1 - 3 7.2 21.4 4.6 6.6 11.2 2.1 2 0 0 2 2 2 0 GPCR-chaperone Vfa1 PF08432.10 CDI79486.1 - 3.2 8.0 36.4 4.8 7.5 7.9 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF2151 PF10221.9 CDI79486.1 - 3.3 6.2 18.0 2.7 6.5 9.1 2.1 2 0 0 2 2 2 0 Cell cycle and development regulator RMP PF14996.6 CDI79486.1 - 3.4 7.9 25.3 4.1 7.6 11.0 2.7 2 0 0 2 2 2 0 Retinal Maintenance OATP PF03137.20 CDI79486.1 - 3.7 5.7 21.7 1.3 7.2 4.4 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family RPA43_OB PF17875.1 CDI79486.1 - 4.1 8.0 25.2 8.1 7.1 6.0 2.7 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I SUFU_C PF12470.8 CDI79486.1 - 4.3 7.3 22.8 5.8 6.9 3.7 2.3 2 0 0 2 2 2 0 Suppressor of Fused Gli/Ci N terminal binding domain GAGA_bind PF06217.12 CDI79486.1 - 4.3 7.5 29.5 5.4 7.2 6.9 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family MMM1 PF10296.9 CDI79486.1 - 4.6 6.2 21.6 4.7 6.2 9.5 2.2 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 RSB_motif PF16294.5 CDI79486.1 - 4.9 7.5 30.0 9.4 6.6 5.8 2.5 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif XRN_M PF17846.1 CDI79486.1 - 5.7 5.8 27.1 3.5 6.5 10.3 2.1 2 0 0 2 2 2 0 Xrn1 helical domain CSRNP_N PF16019.5 CDI79486.1 - 5.9 6.8 32.2 7.7 6.4 7.1 2.3 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus Plasmodium_Vir PF05795.11 CDI79486.1 - 6.3 6.1 18.5 2.5 7.4 1.2 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Peptidase_C58 PF03543.14 CDI79486.1 - 6.4 6.4 40.5 1.8 8.2 9.3 2.4 2 0 0 2 2 2 0 Yersinia/Haemophilus virulence surface antigen PPL5 PF18168.1 CDI79486.1 - 6.6 5.9 27.3 0.76 9.0 12.3 2.2 2 0 0 2 2 2 0 Prim-pol family 5 Sin_N PF04801.13 CDI79486.1 - 7.2 5.7 55.4 1.1 8.3 25.8 2.2 2 0 0 2 2 2 0 Sin-like protein conserved region PA26 PF04636.13 CDI79486.1 - 7.2 5.4 25.9 2 7.2 3.9 2.2 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) MMU163 PF17119.5 CDI79486.1 - 7.9 5.5 19.4 1.5 7.9 7.2 2.3 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis TP53IP5 PF15331.6 CDI79486.1 - 8.3 6.5 25.5 5.8 7.0 6.0 2.3 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 Spore_coat_CotO PF14153.6 CDI79486.1 - 8.5 6.3 53.1 2.9 7.8 16.5 2.3 2 0 0 2 2 2 0 Spore coat protein CotO CTU2 PF10288.9 CDI79486.1 - 9.3 6.5 31.5 5.9 7.2 6.8 2.8 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 LIM_bind PF01803.16 CDI79486.1 - 9.5 5.7 30.9 4.1 6.9 7.0 2.5 2 0 0 2 2 2 0 LIM-domain binding protein CPSF100_C PF13299.6 CDI79496.1 - 0.0083 16.3 5.8 0.0087 16.3 5.8 1.1 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal DUF2828 PF11443.8 CDI79496.1 - 0.0085 14.2 6.1 0.0077 14.4 6.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) CLN3 PF02487.17 CDI79496.1 - 0.015 14.4 5.4 0.016 14.3 5.4 1.0 1 0 0 1 1 1 0 CLN3 protein DUF4834 PF16118.5 CDI79496.1 - 0.015 16.2 13.2 0.022 15.7 13.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF913 PF06025.12 CDI79496.1 - 0.018 14.1 4.2 0.017 14.1 4.2 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4637 PF15470.6 CDI79496.1 - 0.02 14.6 5.2 0.023 14.4 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) TERB2 PF15101.6 CDI79496.1 - 0.021 14.9 18.2 0.024 14.7 18.2 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Connexin PF00029.19 CDI79496.1 - 0.025 14.3 7.7 0.028 14.2 7.7 1.0 1 0 0 1 1 1 0 Connexin SpoIIP PF07454.11 CDI79496.1 - 0.03 13.8 11.2 0.032 13.7 11.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DDHD PF02862.17 CDI79496.1 - 0.034 14.3 9.7 0.037 14.2 9.7 1.1 1 0 0 1 1 1 0 DDHD domain Tim54 PF11711.8 CDI79496.1 - 0.038 12.8 8.5 0.041 12.7 8.5 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PIP5K PF01504.18 CDI79496.1 - 0.039 13.2 6.8 0.035 13.3 6.8 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase RskA PF10099.9 CDI79496.1 - 0.044 14.1 7.5 0.057 13.7 7.5 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF3408 PF11888.8 CDI79496.1 - 0.046 13.9 10.1 0.053 13.7 10.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) RR_TM4-6 PF06459.12 CDI79496.1 - 0.051 13.4 9.4 0.056 13.3 9.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Afi1 PF07792.12 CDI79496.1 - 0.063 13.8 9.6 0.072 13.6 9.6 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Pex14_N PF04695.13 CDI79496.1 - 0.066 13.9 17.9 0.076 13.7 17.9 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Rxt3 PF08642.10 CDI79496.1 - 0.1 13.4 4.3 0.13 13.1 4.3 1.3 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 EPL1 PF10513.9 CDI79496.1 - 0.11 12.8 13.4 0.13 12.7 13.4 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like Peroxin-13_N PF04088.13 CDI79496.1 - 0.12 12.6 5.1 0.14 12.5 5.1 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region FAM176 PF14851.6 CDI79496.1 - 0.13 12.0 6.1 0.15 11.7 6.1 1.1 1 0 0 1 1 1 0 FAM176 family DUF4228 PF14009.6 CDI79496.1 - 0.14 12.6 6.6 0.15 12.4 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Peptidase_S49_N PF08496.10 CDI79496.1 - 0.16 12.0 10.6 0.21 11.7 10.6 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal EOS1 PF12326.8 CDI79496.1 - 0.16 11.9 6.7 0.17 11.8 6.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein TFIIA PF03153.13 CDI79496.1 - 0.16 11.9 32.9 0.17 11.8 32.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RLL PF10036.9 CDI79496.1 - 0.17 11.7 14.3 0.2 11.5 14.3 1.1 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein eIF-3_zeta PF05091.12 CDI79496.1 - 0.17 10.8 16.9 0.18 10.7 16.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Band_3_cyto PF07565.13 CDI79496.1 - 0.19 11.5 11.8 0.21 11.4 11.8 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CCDC117 PF15810.5 CDI79496.1 - 0.22 11.8 10.8 0.28 11.5 10.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 117 Coilin_N PF15862.5 CDI79496.1 - 0.23 11.3 14.1 0.3 10.9 14.1 1.3 1 0 0 1 1 1 0 Coilin N-terminus MMU163 PF17119.5 CDI79496.1 - 0.25 10.5 5.5 0.26 10.4 5.5 1.0 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis SLC12 PF03522.15 CDI79496.1 - 0.25 10.3 11.4 0.27 10.2 11.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4746 PF15928.5 CDI79496.1 - 0.25 10.7 7.2 0.28 10.6 7.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Serinc PF03348.15 CDI79496.1 - 0.26 10.2 5.4 0.26 10.1 5.4 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Sporozoite_P67 PF05642.11 CDI79496.1 - 0.26 9.3 4.1 0.28 9.2 4.1 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen EIIBC-GUT_N PF03612.14 CDI79496.1 - 0.26 11.0 9.8 0.29 10.9 9.8 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3381 PF11861.8 CDI79496.1 - 0.3 10.9 16.7 0.38 10.5 16.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF4770 PF15994.5 CDI79496.1 - 0.34 11.1 12.7 0.42 10.8 12.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Presenilin PF01080.17 CDI79496.1 - 0.37 9.5 15.5 0.42 9.3 15.5 1.0 1 0 0 1 1 1 0 Presenilin Pex26 PF07163.12 CDI79496.1 - 0.38 10.0 11.3 0.45 9.8 11.3 1.1 1 0 0 1 1 1 0 Pex26 protein CCDC53 PF10152.9 CDI79496.1 - 0.39 11.1 12.2 0.43 11.0 12.2 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Folate_carrier PF01770.18 CDI79496.1 - 0.39 9.4 5.3 0.42 9.3 5.3 1.0 1 0 0 1 1 1 0 Reduced folate carrier Med15 PF09606.10 CDI79496.1 - 0.39 9.3 27.9 0.39 9.4 27.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal API5 PF05918.11 CDI79496.1 - 0.42 9.4 12.2 0.47 9.2 12.2 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Orf78 PF06024.12 CDI79496.1 - 0.44 10.9 5.7 0.6 10.4 5.7 1.4 1 0 0 1 1 1 0 Orf78 (ac78) TMEM51 PF15345.6 CDI79496.1 - 0.46 10.3 12.9 0.54 10.1 12.9 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 RPA43_OB PF17875.1 CDI79496.1 - 0.49 11.0 9.9 0.65 10.6 9.9 1.1 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I CobT PF06213.12 CDI79496.1 - 0.5 9.7 20.6 0.61 9.4 20.6 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT ALMT PF11744.8 CDI79496.1 - 0.51 9.1 8.9 0.55 9.0 8.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter MCU PF04678.13 CDI79496.1 - 0.52 10.4 7.6 0.56 10.3 7.6 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Otopetrin PF03189.13 CDI79496.1 - 0.52 9.1 6.4 0.62 8.8 6.4 1.0 1 0 0 1 1 1 0 Otopetrin Ureide_permease PF07168.11 CDI79496.1 - 0.53 9.0 4.9 0.6 8.8 4.9 1.1 1 0 0 1 1 1 0 Ureide permease YABBY PF04690.13 CDI79496.1 - 0.6 10.7 8.6 0.65 10.5 8.6 1.1 1 0 0 1 1 1 0 YABBY protein CSG2 PF16965.5 CDI79496.1 - 0.6 9.0 6.4 0.69 8.8 6.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator V_ATPase_I PF01496.19 CDI79496.1 - 0.61 7.9 14.4 0.71 7.7 14.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PAT1 PF09770.9 CDI79496.1 - 0.63 8.2 20.9 0.66 8.2 20.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 CDI79496.1 - 0.72 9.9 8.4 0.74 9.8 8.4 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Paf1 PF03985.13 CDI79496.1 - 0.78 8.7 16.1 0.9 8.5 16.1 1.0 1 0 0 1 1 1 0 Paf1 Spt20 PF12090.8 CDI79496.1 - 0.82 9.2 45.9 0.97 9.0 45.9 1.0 1 0 0 1 1 1 0 Spt20 family MMR1 PF08505.10 CDI79496.1 - 0.84 9.9 17.1 0.92 9.8 17.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein G0-G1_switch_2 PF15103.6 CDI79496.1 - 0.93 10.0 10.1 1.2 9.6 10.1 1.1 1 0 0 1 1 1 0 G0/G1 switch protein 2 HemX PF04375.14 CDI79496.1 - 1 8.6 23.9 0.98 8.6 23.9 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Baculo_PP31 PF05311.11 CDI79496.1 - 1 8.8 11.2 1.1 8.7 11.2 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Membralin PF09746.9 CDI79496.1 - 1.1 8.3 6.5 1.1 8.2 6.5 1.0 1 0 0 1 1 1 0 Tumour-associated protein SID-1_RNA_chan PF13965.6 CDI79496.1 - 1.1 7.5 5.7 1.2 7.4 5.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TFB6 PF17110.5 CDI79496.1 - 1.2 8.8 7.6 1.5 8.6 7.6 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH ABC2_membrane_2 PF12679.7 CDI79496.1 - 1.3 8.2 3.6 1.3 8.2 3.6 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein MDM31_MDM32 PF08118.11 CDI79496.1 - 1.3 7.6 8.4 1.4 7.5 8.4 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Suf PF05843.14 CDI79496.1 - 1.4 8.8 16.2 1.6 8.7 16.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Peptidase_U57 PF05582.12 CDI79496.1 - 1.5 8.1 8.9 1.7 7.8 8.9 1.0 1 0 0 1 1 1 0 YabG peptidase U57 Hid1 PF12722.7 CDI79496.1 - 1.5 6.9 12.2 1.7 6.7 12.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ctr PF04145.15 CDI79496.1 - 1.6 9.3 8.2 1.8 9.1 8.2 1.1 1 0 0 1 1 1 0 Ctr copper transporter family OATP PF03137.20 CDI79496.1 - 2.1 6.5 6.7 2.2 6.5 6.7 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2722 PF10846.8 CDI79496.1 - 2.2 7.1 36.9 2.7 6.8 36.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) AIF_C PF14721.6 CDI79496.1 - 2.4 8.5 11.3 3 8.2 11.3 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term MDM10 PF12519.8 CDI79496.1 - 3 6.6 15.4 3.7 6.3 15.4 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 PRC2_HTH_1 PF18118.1 CDI79496.1 - 3.2 8.6 11.8 4.2 8.2 11.8 1.1 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain RBP_receptor PF14752.6 CDI79496.1 - 3.3 6.2 9.7 3.5 6.1 9.7 1.0 1 0 0 1 1 1 0 Retinol binding protein receptor FHIPEP PF00771.20 CDI79496.1 - 3.4 6.0 7.8 3.7 5.9 7.8 1.1 1 0 0 1 1 1 0 FHIPEP family RED_N PF07808.13 CDI79496.1 - 3.7 7.1 16.3 4.6 6.8 16.3 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region FliP PF00813.20 CDI79496.1 - 4.1 7.2 6.4 4.9 7.0 6.4 1.1 1 0 0 1 1 1 0 FliP family DUF4407 PF14362.6 CDI79496.1 - 4.5 6.5 16.8 5.4 6.3 16.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DcuA_DcuB PF03605.14 CDI79496.1 - 4.6 6.0 5.1 5 5.9 5.1 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF1980 PF09323.10 CDI79496.1 - 4.9 7.0 11.1 5.9 6.8 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) SprA-related PF12118.8 CDI79496.1 - 5 6.2 27.7 5.2 6.1 27.7 1.0 1 0 0 1 1 1 0 SprA-related family HCO3_cotransp PF00955.21 CDI79496.1 - 5.5 5.7 5.1 5.8 5.6 5.1 1.0 1 0 0 1 1 1 0 HCO3- transporter family Gti1_Pac2 PF09729.9 CDI79496.1 - 5.6 7.0 13.4 6.8 6.7 13.4 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Renin_r PF07850.14 CDI79496.1 - 5.9 7.6 5.3 9.3 6.9 5.3 1.4 1 0 0 1 1 1 0 Renin receptor-like protein Kei1 PF08552.11 CDI79496.1 - 5.9 6.7 10.1 7.2 6.4 10.1 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 UPF0560 PF10577.9 CDI79496.1 - 8.7 4.7 23.1 9.8 4.5 23.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 FPN1 PF06963.12 CDI79496.1 - 9.8 4.6 6.6 11 4.5 6.6 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Fe-S_assembly PF04384.13 CDI79498.1 - 0.023 15.3 0.1 12 6.6 0.0 2.3 2 0 0 2 2 2 0 Iron-sulphur cluster assembly L27 PF02828.16 CDI79498.1 - 0.037 13.8 0.2 6.9 6.5 0.0 2.3 2 0 0 2 2 2 0 L27 domain Fumarate_red_D PF02313.17 CDI79498.1 - 2 8.6 4.8 26 4.9 0.1 2.6 2 1 0 2 2 2 0 Fumarate reductase subunit D DUF4461 PF14688.6 CDI79507.1 - 0.11 12.2 0.5 0.19 11.5 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4461) RIFIN PF02009.16 CDI79507.1 - 0.53 10.1 15.0 0.84 9.5 15.0 1.3 1 0 0 1 1 1 0 Rifin SR-25 PF10500.9 CDI79509.1 - 9.6 5.7 82.6 1.6 8.3 53.4 2.6 1 1 2 3 3 3 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 CDI79515.1 - 1e-07 31.6 0.0 3.6e-06 26.5 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79515.1 - 0.00023 20.5 0.0 0.0004 19.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Spt20 PF12090.8 CDI79515.1 - 2.7 7.5 14.5 4.5 6.8 14.5 1.3 1 0 0 1 1 1 0 Spt20 family RskA PF10099.9 CDI79515.1 - 10 6.4 35.5 1e+03 -0.2 35.5 2.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA EF-hand_1 PF00036.32 CDI79520.1 - 1e-39 131.1 10.2 1.9e-09 36.4 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDI79520.1 - 2.4e-34 117.6 1.9 1.1e-16 61.1 0.5 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CDI79520.1 - 5.7e-32 109.3 10.5 9.5e-16 57.4 0.6 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 CDI79520.1 - 5.5e-28 94.5 6.2 2.1e-09 36.6 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 CDI79520.1 - 3e-25 86.6 8.6 3.7e-06 26.2 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 CDI79520.1 - 1.5e-14 54.1 0.1 6.4e-09 36.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CDI79520.1 - 7.1e-09 35.6 0.3 0.00075 19.4 0.1 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CDI79520.1 - 1.2e-07 32.1 0.1 0.013 15.8 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 CDI79520.1 - 9.7e-06 26.4 0.0 0.0019 19.1 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 CDI79520.1 - 7.8e-05 22.6 0.0 0.07 13.2 0.0 2.5 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) Dockerin_1 PF00404.18 CDI79520.1 - 0.0033 17.6 4.6 0.29 11.4 0.6 2.8 2 2 0 2 2 2 2 Dockerin type I domain DUF3349 PF11829.8 CDI79520.1 - 0.0055 17.4 0.5 2 9.3 0.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Caleosin PF05042.13 CDI79520.1 - 0.0058 16.6 0.1 0.47 10.4 0.1 2.9 1 1 0 1 1 1 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 CDI79520.1 - 0.012 15.9 1.4 2.9 8.2 0.2 2.6 2 1 0 2 2 2 0 RNA polymerase Rpb4 EFhand_Ca_insen PF08726.10 CDI79520.1 - 0.013 15.6 0.7 0.08 13.1 0.0 2.3 2 1 0 2 2 2 0 Ca2+ insensitive EF hand YqeY PF09424.10 CDI79520.1 - 0.026 14.6 0.8 0.37 10.9 0.1 2.4 1 1 1 2 2 2 0 Yqey-like protein SurA_N_2 PF13623.6 CDI79520.1 - 0.035 14.0 1.2 1.8 8.4 0.1 2.3 1 1 1 2 2 2 0 SurA N-terminal domain DUF1103 PF06513.11 CDI79520.1 - 0.037 13.7 2.8 0.049 13.2 2.8 1.3 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) DUF853 PF05872.12 CDI79520.1 - 0.067 11.8 0.2 1.5 7.4 0.1 2.0 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF853) dCache_2 PF08269.11 CDI79520.1 - 0.091 11.9 0.1 9.7 5.3 0.0 2.1 1 1 1 2 2 2 0 Cache domain EF-hand_14 PF17959.1 CDI79520.1 - 0.097 13.0 0.2 19 5.7 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain SurA_N_3 PF13624.6 CDI79520.1 - 0.12 12.2 0.7 1.1 9.1 0.1 2.2 1 1 1 2 2 2 0 SurA N-terminal domain DUF5580 PF17743.1 CDI79520.1 - 0.13 10.8 0.0 0.13 10.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) Fe_hyd_lg_C PF02906.14 CDI79520.1 - 0.17 11.5 0.6 0.54 9.9 0.5 1.8 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain Ribosomal_S10 PF00338.22 CDI79521.1 - 1.3e-25 89.4 0.1 1.6e-25 89.2 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF1922 PF09082.10 CDI79521.1 - 0.02 15.1 0.1 0.048 14.0 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1922) Ribosomal_L35Ae PF01247.18 CDI79522.1 - 1.9e-44 149.7 0.3 2.3e-44 149.4 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 CDI79522.1 - 0.016 15.4 0.1 5.3 7.3 0.0 2.3 2 0 0 2 2 2 0 RimM N-terminal domain OMPdecase PF00215.24 CDI79523.1 - 8.1e-23 81.2 0.0 2.1e-22 79.8 0.0 1.6 1 1 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family HEAT PF02985.22 CDI79526.1 - 7.5e-13 47.6 7.4 0.026 14.7 0.1 8.1 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 CDI79526.1 - 4.4e-06 27.1 0.8 4.4e-06 27.1 0.8 7.0 8 0 0 8 8 8 1 HEAT-like repeat IBN_N PF03810.19 CDI79526.1 - 0.00011 22.0 1.3 0.00061 19.7 0.1 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 CDI79526.1 - 0.00054 20.3 23.2 0.23 11.8 0.4 7.5 6 2 2 8 8 8 2 HEAT repeats Herpes_TAF50 PF03326.13 CDI79526.1 - 0.0031 16.2 1.5 0.0054 15.5 1.5 1.3 1 0 0 1 1 1 1 Herpesvirus transcription activation factor (transactivator) MMS19_C PF12460.8 CDI79526.1 - 0.0035 16.5 0.1 15 4.5 0.0 4.8 4 2 2 6 6 6 1 RNAPII transcription regulator C-terminal PEARLI-4 PF05278.12 CDI79526.1 - 0.13 11.9 0.2 0.6 9.7 0.1 2.0 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) Herpes_IE68 PF02479.16 CDI79526.1 - 0.13 11.8 0.0 0.37 10.4 0.0 1.7 1 0 0 1 1 1 0 Herpesvirus immediate early protein Cohesin_HEAT PF12765.7 CDI79526.1 - 3.1 8.2 7.2 23 5.4 0.1 3.9 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Proteasome PF00227.26 CDI79528.1 - 3.8e-59 199.4 0.0 4.7e-59 199.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDI79528.1 - 2e-13 49.8 0.2 3.4e-13 49.0 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature GM_CSF PF01109.17 CDI79528.1 - 0.011 15.9 0.2 0.027 14.6 0.0 1.7 2 0 0 2 2 2 0 Granulocyte-macrophage colony-stimulating factor DSPc PF00782.20 CDI79531.1 - 3.8e-25 88.2 0.0 5.7e-25 87.7 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 CDI79531.1 - 0.0021 18.2 0.0 0.0054 16.8 0.0 1.7 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 CDI79531.1 - 0.0051 16.4 0.0 0.0084 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF1573 PF07610.11 CDI79532.1 - 9.7e-05 22.3 0.2 9.7e-05 22.3 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1573) ASH PF15780.5 CDI79532.1 - 0.0049 17.1 0.1 0.013 15.7 0.1 1.6 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Sec1 PF00995.23 CDI79534.1 - 2.2e-83 281.4 0.2 1.7e-65 222.4 0.0 2.1 1 1 1 2 2 2 2 Sec1 family YlbD_coat PF14071.6 CDI79534.1 - 0.032 14.5 0.2 0.19 12.0 0.2 2.1 2 0 0 2 2 2 0 Putative coat protein Dor1 PF04124.12 CDI79536.1 - 1.5e-10 40.3 0.1 9.5e-07 27.8 0.0 2.4 2 0 0 2 2 2 2 Dor1-like family PK PF00224.21 CDI79538.1 - 4.7e-146 486.1 0.7 6.3e-146 485.7 0.7 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CDI79538.1 - 3.5e-31 107.9 0.4 8.6e-31 106.6 0.4 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 CDI79538.1 - 0.0026 16.9 0.5 0.01 15.0 0.0 2.2 2 1 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Vps8 PF12816.7 CDI79538.1 - 0.05 13.1 0.1 0.086 12.3 0.1 1.3 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 JAB PF01398.21 CDI79540.1 - 3e-27 95.0 0.4 1.2e-26 92.9 0.4 1.9 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 CDI79540.1 - 1.4e-05 24.9 0.1 7.3e-05 22.5 0.1 2.2 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 CDI79540.1 - 0.014 15.5 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) Utp14 PF04615.13 CDI79543.1 - 2e-12 46.6 3.7 2e-12 46.6 3.7 7.1 1 1 2 6 6 6 1 Utp14 protein Sporozoite_P67 PF05642.11 CDI79543.1 - 5.2e-05 21.6 10.2 5.2e-05 21.6 10.2 8.3 2 1 1 5 5 5 1 Sporozoite P67 surface antigen Autophagy_N PF03986.13 CDI79544.1 - 1.5e-31 109.1 0.0 2.3e-31 108.6 0.0 1.2 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 CDI79544.1 - 1.4e-21 76.9 0.2 2.2e-21 76.2 0.2 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain PHC2_SAM_assoc PF16616.5 CDI79544.1 - 0.019 15.8 0.0 0.033 15.0 0.0 1.4 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Myc_N PF01056.18 CDI79546.1 - 0.0098 15.8 4.0 0.012 15.5 4.0 1.1 1 0 0 1 1 1 1 Myc amino-terminal region UPF0193 PF05250.11 CDI79546.1 - 0.03 14.1 2.4 0.042 13.6 2.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0193) RNA_pol_Rpc4 PF05132.14 CDI79546.1 - 0.032 14.7 1.7 0.032 14.7 1.7 2.2 3 0 0 3 3 3 0 RNA polymerase III RPC4 Apis_Csd PF11671.8 CDI79546.1 - 0.14 12.1 15.1 0.064 13.3 12.7 1.7 2 0 0 2 2 2 0 Complementary sex determiner protein SH3-WW_linker PF16618.5 CDI79546.1 - 0.53 10.7 5.3 0.92 10.0 5.3 1.3 1 0 0 1 1 1 0 Linker region between SH3 and WW domains on ARHGAP12 GARP PF16731.5 CDI79546.1 - 9.5 5.8 36.7 5.1 6.7 12.2 2.2 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF3824 PF12868.7 CDI79568.1 - 0.0065 17.1 3.5 0.0065 17.1 3.5 6.6 5 2 0 5 5 5 1 Domain of unknwon function (DUF3824) Apt1 PF10351.9 CDI79568.1 - 4.2 6.1 27.0 1.1 8.1 23.5 1.6 2 0 0 2 2 2 0 Golgi-body localisation protein domain DUF4902 PF16245.5 CDI79578.1 - 0.037 13.9 0.7 0.12 12.2 0.1 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4902) Virul_Fac PF10139.9 CDI79578.1 - 1.2 7.3 14.4 1.3 7.2 14.4 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor GRIM-19 PF06212.12 CDI79578.1 - 1.3 9.0 5.2 1.1 9.2 3.6 1.7 1 1 1 2 2 2 0 GRIM-19 protein SAGA-Tad1 PF12767.7 CDI79586.1 - 0.0014 18.4 19.4 0.002 17.9 19.4 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit DUF572 PF04502.13 CDI79586.1 - 0.017 14.7 17.4 0.022 14.4 17.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) LAP1C PF05609.12 CDI79586.1 - 0.5 9.4 24.6 0.58 9.2 24.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PAT1 PF09770.9 CDI79586.1 - 0.59 8.3 40.9 0.69 8.1 40.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 CDI79586.1 - 0.64 9.0 24.2 0.84 8.6 24.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 CDI79586.1 - 0.78 8.0 26.1 0.97 7.6 26.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2151 PF10221.9 CDI79586.1 - 1 7.9 14.5 1.2 7.6 14.5 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Coilin_N PF15862.5 CDI79586.1 - 1.5 8.6 30.2 0.32 10.8 12.6 2.2 2 0 0 2 2 2 0 Coilin N-terminus EIIBC-GUT_N PF03612.14 CDI79586.1 - 1.5 8.5 23.3 0.29 10.9 1.6 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus AUX_IAA PF02309.16 CDI79586.1 - 3.3 7.5 16.3 4.6 7.0 16.3 1.2 1 0 0 1 1 1 0 AUX/IAA family Ndc1_Nup PF09531.10 CDI79586.1 - 7.3 5.2 26.9 8.9 4.9 26.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup XRN_M PF17846.1 CDI79586.1 - 8.6 5.2 16.9 12 4.8 16.9 1.3 1 0 0 1 1 1 0 Xrn1 helical domain IMUP PF15761.5 CDI79589.1 - 0.018 15.7 7.2 0.018 15.7 7.2 5.2 2 1 1 4 4 4 0 Immortalisation up-regulated protein SVIP PF15811.5 CDI79589.1 - 0.021 15.2 2.4 0.021 15.2 2.4 2.8 3 0 0 3 3 3 0 Small VCP/p97-interacting protein TFIIA PF03153.13 CDI79589.1 - 2.4 8.1 57.7 3.6 7.5 57.5 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 CDI79591.1 - 0.061 14.3 19.5 0.073 14.0 3.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 CDI79591.1 - 0.2 12.5 8.4 4.3 8.3 3.4 2.6 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SRP-alpha_N PF04086.13 CDI79591.1 - 0.25 11.2 26.9 0.32 10.9 26.9 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Hamartin PF04388.12 CDI79591.1 - 0.26 9.9 22.2 0.28 9.8 22.2 1.1 1 0 0 1 1 1 0 Hamartin protein PA26 PF04636.13 CDI79591.1 - 0.55 9.1 11.2 0.79 8.6 11.2 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4551 PF15087.6 CDI79591.1 - 0.79 8.5 14.5 0.98 8.2 14.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF3439 PF11921.8 CDI79591.1 - 0.88 9.5 17.0 1.6 8.7 6.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) TFB6 PF17110.5 CDI79591.1 - 1.1 8.9 10.1 0.4 10.4 1.2 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH SOBP PF15279.6 CDI79591.1 - 1.2 9.7 20.8 1.4 9.4 20.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein SARAF PF06682.12 CDI79591.1 - 1.2 8.7 19.3 1.8 8.1 19.3 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Miff PF05644.11 CDI79591.1 - 1.4 8.5 18.4 2.1 7.9 18.4 1.2 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Apt1 PF10351.9 CDI79591.1 - 1.5 7.6 10.8 1.9 7.2 10.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Eapp_C PF10238.9 CDI79591.1 - 2.3 8.3 18.1 2.6 8.1 5.3 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein Conotoxin PF02950.17 CDI79591.1 - 3.9 8.5 15.2 1.1 10.3 2.8 2.6 2 0 0 2 2 2 0 Conotoxin PPP4R2 PF09184.11 CDI79591.1 - 5.2 6.6 11.1 6.6 6.2 11.1 1.1 1 0 0 1 1 1 0 PPP4R2 Macoilin PF09726.9 CDI79591.1 - 6.3 5.2 18.5 8.2 4.8 18.5 1.2 1 0 0 1 1 1 0 Macoilin family Peptidase_S49_N PF08496.10 CDI79591.1 - 6.6 6.8 16.8 4.1 7.4 5.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal SR-25 PF10500.9 CDI79591.1 - 7.5 6.1 21.7 30 4.1 21.7 1.8 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI79591.1 - 7.5 5.4 39.1 4.5 6.1 12.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Coilin_N PF15862.5 CDI79591.1 - 8.7 6.1 24.4 1.3 8.8 7.6 2.1 2 0 0 2 2 2 0 Coilin N-terminus SR-25 PF10500.9 CDI79607.1 - 0.0019 17.9 13.1 0.0019 17.9 13.1 3.8 4 0 0 4 4 4 2 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI79607.1 - 0.0074 16.3 11.7 0.0074 16.3 11.7 4.0 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit zf-HC5HC2H_2 PF13832.6 CDI79607.1 - 1.8 8.7 7.9 0.59 10.3 0.8 3.3 3 0 0 3 3 3 0 PHD-zinc-finger like domain TipE PF16972.5 CDI79607.1 - 8.1 5.5 8.1 21 4.1 8.1 1.6 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE TFIIA PF03153.13 CDI79656.1 - 0.13 12.2 24.7 0.16 11.9 24.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI79656.1 - 0.32 11.3 9.5 0.41 10.9 9.5 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Suf PF05843.14 CDI79656.1 - 0.5 10.3 12.2 0.68 9.9 12.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hydin_ADK PF17213.3 CDI79656.1 - 0.57 10.4 10.9 0.77 10.0 10.9 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Senescence_reg PF04520.13 CDI79656.1 - 1 10.2 7.6 1.5 9.6 7.6 1.2 1 0 0 1 1 1 0 Senescence regulator NEMP PF10225.9 CDI79656.1 - 2.5 7.7 6.7 0.71 9.5 3.7 1.6 1 1 1 2 2 2 0 NEMP family PAT1 PF09770.9 CDI79656.1 - 4.5 5.4 18.0 5.1 5.2 18.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI79656.1 - 8.7 3.3 14.2 9.9 3.1 14.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AIF_C PF14721.6 CDI79660.1 - 1.2e-05 25.6 6.0 1.2e-05 25.6 6.0 2.1 1 1 1 2 2 2 1 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF1645 PF07816.11 CDI79660.1 - 0.0007 20.2 15.8 0.00088 19.9 15.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1645) Macoilin PF09726.9 CDI79660.1 - 0.012 14.2 23.8 0.014 14.0 23.8 1.0 1 0 0 1 1 1 0 Macoilin family CCSAP PF15748.5 CDI79660.1 - 0.012 15.8 20.3 0.016 15.4 20.3 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Apt1 PF10351.9 CDI79660.1 - 0.013 14.4 20.8 0.015 14.2 20.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 CDI79660.1 - 0.016 14.8 26.3 0.02 14.5 26.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4175 PF13779.6 CDI79660.1 - 0.018 13.0 23.0 0.019 12.9 23.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF5327 PF17261.2 CDI79660.1 - 0.02 15.7 12.3 0.02 15.7 12.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5327) SRP-alpha_N PF04086.13 CDI79660.1 - 0.024 14.6 18.9 0.03 14.2 18.9 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Plasmodium_Vir PF05795.11 CDI79660.1 - 0.03 13.8 12.6 0.031 13.7 12.6 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TFIIA PF03153.13 CDI79660.1 - 0.035 14.1 35.7 0.041 13.9 35.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1387 PF07139.11 CDI79660.1 - 0.041 13.6 22.6 0.047 13.4 22.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) BORG_CEP PF14957.6 CDI79660.1 - 0.087 14.0 15.0 0.12 13.5 15.0 1.3 1 0 0 1 1 1 0 Cdc42 effector Presenilin PF01080.17 CDI79660.1 - 0.1 11.4 24.2 0.12 11.1 24.2 1.1 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 CDI79660.1 - 0.14 11.5 7.6 0.13 11.6 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EMC3_TMCO1 PF01956.16 CDI79660.1 - 0.23 11.2 12.8 0.29 10.9 12.8 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like GREB1 PF15782.5 CDI79660.1 - 0.28 8.2 24.3 0.32 8.1 24.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DcuA_DcuB PF03605.14 CDI79660.1 - 0.44 9.4 2.2 0.45 9.3 2.2 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Peptidase_S64 PF08192.11 CDI79660.1 - 0.62 8.5 28.3 0.75 8.2 28.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 Ndc1_Nup PF09531.10 CDI79660.1 - 0.63 8.7 17.2 0.74 8.4 17.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup UPF0239 PF06783.11 CDI79660.1 - 0.65 10.2 14.3 0.4 10.9 5.6 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) TFIIF_alpha PF05793.12 CDI79660.1 - 0.66 8.5 22.7 0.86 8.1 22.7 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SLC12 PF03522.15 CDI79660.1 - 0.88 8.5 21.6 1.1 8.2 21.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PepSY_TM PF03929.16 CDI79660.1 - 1.1 8.9 4.8 1.2 8.8 4.8 1.1 1 0 0 1 1 1 0 PepSY-associated TM region DUF3347 PF11827.8 CDI79660.1 - 1.4 9.1 24.5 2 8.6 24.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) MscS_TM PF12794.7 CDI79660.1 - 2.6 6.8 7.4 3.6 6.4 7.4 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 eIF-3_zeta PF05091.12 CDI79660.1 - 2.6 6.9 21.8 3.1 6.7 21.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FCP1_C PF09309.10 CDI79660.1 - 2.6 7.8 23.6 3.6 7.4 23.6 1.2 1 0 0 1 1 1 0 FCP1, C-terminal XRN_M PF17846.1 CDI79660.1 - 4.1 6.3 14.4 4.9 6.0 14.4 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Miga PF10265.9 CDI79660.1 - 4.4 6.2 20.5 5.1 6.0 20.5 1.0 1 0 0 1 1 1 0 Mitoguardin PAT1 PF09770.9 CDI79660.1 - 4.6 5.4 26.9 5.4 5.2 26.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2615 PF11027.8 CDI79660.1 - 6.6 6.9 17.9 1.8 8.7 10.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2615) O-antigen_lig PF13425.6 CDI79660.1 - 8.9 5.0 11.4 12 4.6 11.4 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Presenilin PF01080.17 CDI79664.1 - 0.0094 14.8 2.3 0.012 14.4 2.3 1.1 1 0 0 1 1 1 1 Presenilin SOG2 PF10428.9 CDI79664.1 - 0.048 12.9 15.6 0.072 12.3 15.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 CDI79664.1 - 0.081 12.8 15.4 0.1 12.5 15.4 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI79664.1 - 0.28 10.0 18.7 0.36 9.6 18.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain CPSF100_C PF13299.6 CDI79664.1 - 0.3 11.3 1.3 0.52 10.5 1.3 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Hid1 PF12722.7 CDI79664.1 - 0.51 8.4 4.1 0.61 8.1 4.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CDI79664.1 - 5.7 3.9 13.4 7 3.6 13.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Plasmodium_Vir PF05795.11 CDI79664.1 - 6.4 6.1 10.7 8.6 5.7 10.7 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Raftlin PF15250.6 CDI79664.1 - 6.8 5.3 7.5 9.5 4.8 7.5 1.1 1 0 0 1 1 1 0 Raftlin DUF572 PF04502.13 CDI79664.1 - 7.3 6.1 9.7 10 5.6 9.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Phage_holin_3_5 PF16085.5 CDI79664.1 - 9.5 6.4 22.9 0.078 13.1 8.6 2.7 3 0 0 3 3 3 0 Bacteriophage holin Hol, superfamily III ABC_ATPase PF09818.9 CDI79709.1 - 7.3e-77 259.1 0.9 4.6e-76 256.4 0.9 1.9 1 1 0 1 1 1 1 Predicted ATPase of the ABC class AAA_23 PF13476.6 CDI79709.1 - 0.00016 22.3 0.0 0.00028 21.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDI79709.1 - 0.027 14.2 0.1 0.074 12.8 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DAO PF01266.24 CDI79709.1 - 0.1 12.2 0.0 12 5.4 0.0 2.3 2 1 0 2 2 2 0 FAD dependent oxidoreductase Peptidase_S64 PF08192.11 CDI79729.1 - 0.12 10.8 20.2 0.17 10.4 20.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 U1snRNP70_N PF12220.8 CDI79729.1 - 0.46 11.2 11.8 1.7 9.3 2.0 2.4 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Trp_oprn_chp PF09534.10 CDI79729.1 - 0.55 10.0 23.8 0.28 11.0 19.4 2.1 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) MAT1 PF06391.13 CDI79729.1 - 1.1 9.0 23.0 1.1 9.0 3.3 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 PPP4R2 PF09184.11 CDI79729.1 - 3.2 7.3 14.3 3.7 7.1 14.3 1.3 1 0 0 1 1 1 0 PPP4R2 XRCC4 PF06632.12 CDI79740.1 - 0.0039 16.1 6.1 0.0039 16.1 6.1 4.6 3 1 1 4 4 4 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 Synaptobrevin PF00957.21 CDI79746.1 - 1.4 8.7 2.8 27 4.6 0.1 2.4 2 0 0 2 2 2 0 Synaptobrevin Nudix_hydro PF18290.1 CDI79747.1 - 0.0047 16.9 0.0 0.097 12.7 0.0 2.5 2 0 0 2 2 2 1 Nudix hydrolase domain Plasmid_RAQPRD PF09686.10 CDI79747.1 - 1.2 9.4 5.1 0.9 9.8 0.9 2.7 3 0 0 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Spt20 PF12090.8 CDI79748.1 - 0.0024 17.5 27.2 0.0024 17.5 27.2 16.1 8 4 7 15 15 15 3 Spt20 family WD40 PF00400.32 CDI79748.1 - 0.018 15.9 0.0 0.21 12.5 0.0 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat Rtf2 PF04641.12 CDI79748.1 - 0.083 12.2 0.0 0.083 12.2 0.0 11.4 10 2 1 11 11 11 0 Rtf2 RING-finger Trp_oprn_chp PF09534.10 CDI79749.1 - 0.018 14.9 9.9 0.018 14.8 9.9 1.0 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) BAF1_ABF1 PF04684.13 CDI79749.1 - 0.57 9.2 21.1 0.63 9.0 21.1 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor 2HCT PF03390.15 CDI79749.1 - 3.9 6.0 6.1 5 5.6 6.1 1.3 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family RskA PF10099.9 CDI79749.1 - 4.3 7.6 33.0 8.2 6.7 33.0 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA SID-1_RNA_chan PF13965.6 CDI79749.1 - 5.8 5.2 7.1 7.5 4.8 7.1 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CD20 PF04103.15 CDI79749.1 - 7.9 6.5 4.8 1.9 8.6 0.9 1.7 1 1 1 2 2 2 0 CD20-like family FAM60A PF15396.6 CDI79749.1 - 8.2 6.4 19.6 9.4 6.2 19.6 1.0 1 0 0 1 1 1 0 Protein Family FAM60A SDA1 PF05285.12 CDI79752.1 - 0.19 11.1 27.8 0.25 10.7 27.8 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 CDI79752.1 - 0.4 8.8 22.8 0.45 8.7 22.8 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2151 PF10221.9 CDI79752.1 - 0.92 8.0 18.9 1.1 7.8 18.9 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator PI3K_1B_p101 PF10486.9 CDI79752.1 - 4.3 5.0 43.0 5.4 4.7 43.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit MAP65_ASE1 PF03999.12 CDI79752.1 - 5.2 5.6 40.7 6.5 5.3 40.7 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DNA_pol3_a_NII PF11490.8 CDI79752.1 - 5.4 6.9 18.1 10 6.0 18.1 1.4 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II DUF2722 PF10846.8 CDI79789.1 - 0.0011 18.1 3.2 0.0011 18.1 3.2 4.2 3 1 0 3 3 3 1 Protein of unknown function (DUF2722) Med15 PF09606.10 CDI79789.1 - 0.0031 16.3 4.7 0.0031 16.3 4.7 3.3 3 1 1 4 4 4 1 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.8 CDI79789.1 - 0.009 15.7 11.0 0.009 15.7 11.0 4.0 3 1 0 3 3 3 1 Spt20 family RskA PF10099.9 CDI79789.1 - 0.011 16.0 10.6 0.011 16.0 10.6 4.8 2 2 1 4 4 4 0 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI79789.1 - 0.015 15.3 3.3 0.015 15.3 3.3 5.2 4 1 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 DUF2368 PF10166.9 CDI79789.1 - 2 8.1 12.0 0.57 9.8 1.2 2.8 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2368) RskA PF10099.9 CDI79804.1 - 0.0034 17.7 32.4 0.028 14.7 20.8 2.1 1 1 1 2 2 2 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI79804.1 - 0.013 15.5 33.1 0.015 15.3 33.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF5585 PF17823.1 CDI79804.1 - 0.62 8.9 38.1 0.79 8.6 38.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Secretin_N_2 PF07655.13 CDI79804.1 - 1.1 9.9 16.3 0.33 11.5 6.2 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain Peptidase_S15 PF02129.18 CDI79804.1 - 5.2 6.6 12.4 1.4 8.4 9.3 1.5 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Atrophin-1 PF03154.15 CDI79804.1 - 6.2 5.0 32.6 8.1 4.6 32.6 1.0 1 0 0 1 1 1 0 Atrophin-1 family HABP4_PAI-RBP1 PF04774.15 CDI79808.1 - 1.5e-18 67.7 12.2 1.5e-18 67.7 12.2 3.2 2 1 1 3 3 3 1 Hyaluronan / mRNA binding family DUF4770 PF15994.5 CDI79808.1 - 0.95 9.7 10.2 0.033 14.4 2.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Pex14_N PF04695.13 CDI79808.1 - 1.7 9.3 18.0 0.068 13.8 8.2 2.3 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SR-25 PF10500.9 CDI79811.1 - 0.0092 15.6 2.2 0.0092 15.6 2.2 5.3 4 1 1 5 5 5 3 Nuclear RNA-splicing-associated protein DUF4207 PF13904.6 CDI79811.1 - 0.016 14.9 1.2 0.016 14.9 1.2 4.3 3 1 1 4 4 4 0 Domain of unknown function (DUF4207) SID-1_RNA_chan PF13965.6 CDI79811.1 - 1.6 7.1 8.8 0.21 10.0 4.4 1.6 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 HhH-GPD PF00730.25 CDI79824.1 - 1.7e-06 28.4 0.0 1.7e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein DUF2400 PF09674.10 CDI79824.1 - 0.071 13.1 0.0 0.071 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) RNA_pol_A_CTD PF03118.15 CDI79825.1 - 0.0004 20.1 0.0 0.0009 19.0 0.0 1.7 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain CPSF100_C PF13299.6 CDI79825.1 - 0.00099 19.3 10.8 0.0014 18.8 10.8 1.2 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 CDI79825.1 - 0.0014 17.5 12.8 0.0016 17.3 12.8 1.0 1 0 0 1 1 1 1 Presenilin MCM_bind PF09739.9 CDI79825.1 - 0.0018 16.8 6.4 0.0018 16.8 6.4 1.0 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor Pex14_N PF04695.13 CDI79825.1 - 0.005 17.5 12.1 0.005 17.5 12.1 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM76 PF16046.5 CDI79825.1 - 0.0084 15.5 7.8 0.0077 15.6 7.8 1.1 1 0 0 1 1 1 1 FAM76 protein EPL1 PF10513.9 CDI79825.1 - 0.0098 16.3 11.1 0.0098 16.3 11.1 1.2 1 0 0 1 1 1 1 Enhancer of polycomb-like Connexin PF00029.19 CDI79825.1 - 0.015 15.0 6.0 0.015 15.0 6.0 1.1 1 0 0 1 1 1 0 Connexin DUF5308 PF17233.2 CDI79825.1 - 0.018 15.3 7.1 0.016 15.4 7.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DDHD PF02862.17 CDI79825.1 - 0.03 14.5 7.0 0.034 14.3 7.0 1.2 1 0 0 1 1 1 0 DDHD domain TFIIA PF03153.13 CDI79825.1 - 0.03 14.3 26.6 0.028 14.5 26.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit OATP PF03137.20 CDI79825.1 - 0.074 11.3 1.7 0.09 11.0 1.7 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF913 PF06025.12 CDI79825.1 - 0.078 11.9 5.9 0.07 12.1 5.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2151 PF10221.9 CDI79825.1 - 0.09 11.4 4.8 0.081 11.5 4.8 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator PAT1 PF09770.9 CDI79825.1 - 0.091 11.0 19.6 0.086 11.1 19.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Velvet PF11754.8 CDI79825.1 - 0.097 12.6 7.6 0.095 12.6 7.6 1.1 1 0 0 1 1 1 0 Velvet factor RP-C_C PF11800.8 CDI79825.1 - 0.11 12.6 9.3 0.12 12.4 9.3 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region eIF-3_zeta PF05091.12 CDI79825.1 - 0.15 11.0 13.7 0.16 10.9 13.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4175 PF13779.6 CDI79825.1 - 0.17 9.7 28.8 0.17 9.8 28.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) UPF0560 PF10577.9 CDI79825.1 - 0.18 10.3 20.6 0.19 10.2 20.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 SpoIIP PF07454.11 CDI79825.1 - 0.19 11.2 15.4 0.21 11.0 15.4 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Peptidase_S64 PF08192.11 CDI79825.1 - 0.33 9.4 10.1 0.32 9.4 10.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Tim54 PF11711.8 CDI79825.1 - 0.35 9.6 14.0 0.37 9.5 14.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF908 PF06012.12 CDI79825.1 - 0.43 10.0 9.2 0.47 9.8 9.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Otopetrin PF03189.13 CDI79825.1 - 0.5 9.1 5.7 0.53 9.0 5.7 1.0 1 0 0 1 1 1 0 Otopetrin CDC45 PF02724.14 CDI79825.1 - 0.76 8.0 17.7 0.81 7.9 17.7 1.1 1 0 0 1 1 1 0 CDC45-like protein GET2 PF08690.10 CDI79825.1 - 1.2 8.8 12.0 1.1 8.9 12.0 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 ASC PF00858.24 CDI79825.1 - 1.7 7.5 5.3 1.6 7.6 5.3 1.0 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel PTPRCAP PF15713.5 CDI79825.1 - 1.8 8.8 28.4 2.2 8.6 28.4 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated BORG_CEP PF14957.6 CDI79825.1 - 1.9 9.7 9.9 2.1 9.5 9.9 1.2 1 0 0 1 1 1 0 Cdc42 effector NPR3 PF03666.13 CDI79825.1 - 2 7.1 15.2 2.3 6.9 15.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MMR1 PF08505.10 CDI79825.1 - 2.2 8.5 15.1 2.5 8.3 15.1 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF4484 PF14831.6 CDI79825.1 - 2.4 8.1 14.8 1.4 8.9 13.1 1.6 2 0 0 2 2 1 0 Domain of unknown function (DUF4484) SAPS PF04499.15 CDI79825.1 - 2.5 6.8 13.4 2.6 6.7 13.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ndc1_Nup PF09531.10 CDI79825.1 - 3.1 6.4 6.9 2.8 6.5 6.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Folliculin PF11704.8 CDI79825.1 - 3.1 7.6 8.9 4.2 7.2 8.9 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Zip PF02535.22 CDI79825.1 - 3.4 6.8 13.3 3.6 6.7 13.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PepSY_TM PF03929.16 CDI79825.1 - 3.7 7.1 5.1 3.9 7.1 5.1 1.2 1 0 0 1 1 1 0 PepSY-associated TM region Neur_chan_memb PF02932.16 CDI79825.1 - 4.2 7.4 15.5 4.8 7.2 15.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sec62 PF03839.16 CDI79825.1 - 4.5 6.7 13.9 5 6.6 13.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Borrelia_P83 PF05262.11 CDI79825.1 - 5.5 5.4 17.5 5.5 5.4 17.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Peptidase_S15 PF02129.18 CDI79825.1 - 6 6.4 9.9 6.7 6.2 9.9 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) SLC12 PF03522.15 CDI79825.1 - 7 5.5 16.8 7.7 5.4 16.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 CDI79825.1 - 7.3 5.3 12.8 8.1 5.1 12.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter MDM10 PF12519.8 CDI79825.1 - 8 5.2 14.4 8.9 5.1 14.4 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 AnfO_nitrog PF09582.10 CDI79841.1 - 0.05 12.9 0.3 0.14 11.5 0.3 1.7 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) DUF1454 PF07305.12 CDI79841.1 - 0.051 13.0 2.7 0.11 12.0 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1454) Spore_YhcN_YlaJ PF09580.10 CDI79841.1 - 4.7 7.3 9.4 0.69 10.0 0.1 3.0 3 0 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) ArsP_1 PF03773.13 CDI79877.1 - 5.5 6.0 5.1 12 5.0 5.1 1.8 1 1 0 1 1 1 0 Predicted permease DUF2722 PF10846.8 CDI79883.1 - 0.00081 18.4 14.6 0.001 18.1 14.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI79883.1 - 0.011 15.3 21.7 0.014 15.1 21.7 1.1 1 0 0 1 1 1 0 Spt20 family EPL1 PF10513.9 CDI79883.1 - 0.084 13.3 5.6 0.099 13.0 5.6 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Allexi_40kDa PF05549.11 CDI79883.1 - 0.31 10.5 5.3 0.4 10.1 5.3 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein TMEM52 PF14979.6 CDI79883.1 - 0.75 9.7 5.4 1.8 8.5 5.4 1.6 1 0 0 1 1 1 0 Transmembrane 52 MecA PF05389.12 CDI79883.1 - 0.76 9.4 9.6 1.1 8.8 9.6 1.2 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) GREB1 PF15782.5 CDI79883.1 - 1.9 5.5 8.7 1.9 5.5 8.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer EIIBC-GUT_N PF03612.14 CDI79883.1 - 7.3 6.3 7.8 14 5.3 7.8 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus PT PF04886.12 CDI79891.1 - 6.6e-08 32.0 26.5 0.00032 20.2 0.8 4.6 3 1 0 3 3 3 3 PT repeat Apt1 PF10351.9 CDI79891.1 - 0.015 14.1 28.9 2.1e+03 -2.8 28.9 3.3 1 1 0 1 1 1 0 Golgi-body localisation protein domain Ribosomal_60s PF00428.19 CDI79891.1 - 0.03 14.9 24.5 0.2 12.2 18.5 3.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein SpoIIIAH PF12685.7 CDI79891.1 - 0.23 11.3 27.1 0.17 11.7 19.6 3.0 3 0 0 3 3 3 0 SpoIIIAH-like protein DUF4667 PF15700.5 CDI79891.1 - 0.24 11.5 0.0 0.24 11.5 0.0 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4667) RIFIN PF02009.16 CDI79891.1 - 1 9.2 3.9 1.6 8.5 3.9 1.3 1 0 0 1 1 1 0 Rifin RskA PF10099.9 CDI79906.1 - 0.00026 21.3 7.0 0.00029 21.2 7.0 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA FAM199X PF15814.5 CDI79906.1 - 0.021 13.9 30.2 0.022 13.8 30.2 1.0 1 0 0 1 1 1 0 Protein family FAM199X SprA-related PF12118.8 CDI79906.1 - 0.04 13.0 38.3 0.049 12.8 38.3 1.0 1 0 0 1 1 1 0 SprA-related family Med3 PF11593.8 CDI79906.1 - 0.085 12.0 32.0 0.13 11.4 32.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Nop53 PF07767.11 CDI79906.1 - 0.21 10.9 20.5 0.25 10.7 20.5 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DOCK_N PF16172.5 CDI79906.1 - 0.29 10.0 13.0 0.42 9.5 13.0 1.4 1 0 0 1 1 1 0 DOCK N-terminus C_Hendra PF16821.5 CDI79906.1 - 0.48 10.3 13.0 0.55 10.1 13.0 1.1 1 0 0 1 1 1 0 C protein from hendra and measles viruses BAF1_ABF1 PF04684.13 CDI79906.1 - 0.57 9.2 24.7 0.62 9.1 24.7 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor NAM-associated PF14303.6 CDI79906.1 - 0.61 10.8 25.5 0.81 10.4 25.5 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain ICAP-1_inte_bdg PF10480.9 CDI79906.1 - 1.7 8.6 17.8 2 8.3 17.8 1.1 1 0 0 1 1 1 0 Beta-1 integrin binding protein ACC_epsilon PF13822.6 CDI79906.1 - 2.5 8.8 9.4 3 8.6 7.0 2.3 1 1 1 2 2 2 0 Acyl-CoA carboxylase epsilon subunit SR-25 PF10500.9 CDI79906.1 - 3 7.4 48.8 0.62 9.6 22.2 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 CDI79906.1 - 3 6.5 29.3 3.7 6.2 29.3 1.1 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CDI79906.1 - 3.1 7.7 26.5 3.7 7.4 26.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PA26 PF04636.13 CDI79906.1 - 4.5 6.1 17.9 5.3 5.8 17.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Tmemb_cc2 PF10267.9 CDI79906.1 - 6.7 5.7 25.8 7.1 5.7 25.8 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein PARM PF17061.5 CDI79906.1 - 8.7 6.4 27.1 11 6.1 27.1 1.1 1 0 0 1 1 1 0 PARM Nop14 PF04147.12 CDI79906.1 - 9.3 4.3 20.4 11 4.1 20.4 1.0 1 0 0 1 1 1 0 Nop14-like family MYT1 PF08474.11 CDI79906.1 - 9.6 6.1 22.5 14 5.5 22.5 1.2 1 0 0 1 1 1 0 Myelin transcription factor 1 XRCC4 PF06632.12 CDI79906.1 - 9.8 4.9 21.7 12 4.7 21.7 1.0 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF966 PF06136.13 CDI79906.1 - 9.9 5.8 28.2 11 5.6 28.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Spt20 PF12090.8 CDI79907.1 - 0.0042 16.7 11.9 0.0042 16.7 11.9 13.3 7 3 2 10 10 10 5 Spt20 family RskA PF10099.9 CDI79909.1 - 0.00064 20.1 2.1 0.00064 20.1 2.1 17.8 4 2 5 10 10 10 3 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI79918.1 - 0.0097 16.0 23.9 0.016 15.2 10.5 7.5 4 1 2 6 6 6 2 Unstructured region C-term to UIM in Ataxin3 Auxin_canalis PF05703.11 CDI79919.1 - 3.5 7.5 16.8 5 7.0 16.8 1.3 1 0 0 1 1 1 0 Auxin canalisation SID-1_RNA_chan PF13965.6 CDI79919.1 - 4.3 5.6 13.9 5 5.4 13.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Membralin PF09746.9 CDI79933.1 - 7.3 5.5 21.4 9.3 5.2 21.4 1.1 1 0 0 1 1 1 0 Tumour-associated protein SR-25 PF10500.9 CDI79944.1 - 0.38 10.3 57.9 0.037 13.6 13.4 4.6 4 1 0 4 4 4 0 Nuclear RNA-splicing-associated protein TPR_2 PF07719.17 CDI79964.1 - 0.00088 19.2 0.0 0.046 13.8 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDI79964.1 - 0.016 15.0 0.0 0.061 13.2 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4148 PF13663.6 CDI79964.1 - 0.018 15.2 8.3 0.19 11.9 1.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) Mitofilin PF09731.9 CDI79964.1 - 0.021 13.7 21.8 0.035 12.9 21.8 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein GT87 PF09594.10 CDI79964.1 - 0.024 14.4 1.0 3.5 7.3 0.5 2.1 2 0 0 2 2 2 0 Glycosyltransferase family 87 Med15 PF09606.10 CDI79964.1 - 0.051 12.3 41.5 0.063 12.0 41.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Shadoo PF14999.6 CDI79964.1 - 0.067 13.3 8.9 0.5 10.5 0.4 2.8 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective DUF4045 PF13254.6 CDI79964.1 - 0.078 12.6 19.7 0.11 12.1 19.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Endostatin PF06482.11 CDI79964.1 - 0.088 12.3 12.5 0.15 11.5 12.5 1.4 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin TPR_17 PF13431.6 CDI79964.1 - 0.1 13.0 0.0 0.1 13.0 0.0 2.8 3 0 0 3 3 1 0 Tetratricopeptide repeat BAF1_ABF1 PF04684.13 CDI79964.1 - 0.11 11.6 19.4 0.15 11.1 12.4 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor MLANA PF14991.6 CDI79964.1 - 0.23 11.7 7.0 2.3 8.5 0.1 2.4 2 0 0 2 2 2 0 Protein melan-A PAT1 PF09770.9 CDI79964.1 - 1.7 6.9 31.3 2.2 6.4 31.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2681 PF10883.8 CDI79964.1 - 2.6 8.5 37.7 1.6 9.2 6.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) MAT1 PF06391.13 CDI79964.1 - 2.8 7.7 26.5 1.4 8.7 19.8 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 AF-4 PF05110.13 CDI79964.1 - 3.2 5.7 28.2 4.2 5.3 28.2 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4647 PF15504.6 CDI79964.1 - 5.4 6.0 25.0 0.1 11.7 13.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) OATP PF03137.20 CDI79964.1 - 6.1 5.0 9.4 0.94 7.7 5.1 1.7 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TMEM51 PF15345.6 CDI79964.1 - 6.8 6.5 23.5 2.4 7.9 15.3 2.3 2 0 0 2 2 2 0 Transmembrane protein 51 SARAF PF06682.12 CDI79964.1 - 9.5 5.8 22.9 2.6 7.6 17.5 2.1 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis BSD PF03909.17 CDI79980.1 - 1.5e-05 24.9 0.1 2.9e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 BSD domain WD40 PF00400.32 CDI79982.1 - 0.0027 18.5 0.2 15 6.6 0.0 4.1 3 0 0 3 3 3 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 CDI79982.1 - 0.1 11.5 0.2 1.6 7.6 0.0 2.9 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein LRRCT PF01463.24 CDI79982.1 - 1.8 9.3 10.8 15 6.4 0.0 5.1 7 0 0 7 7 7 0 Leucine rich repeat C-terminal domain DEAD PF00270.29 CDI79986.1 - 3.2e-12 46.6 0.2 5.5e-12 45.8 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDI79986.1 - 0.0019 18.2 0.0 0.0035 17.4 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Dala_Dala_lig_N PF01820.21 CDI79992.1 - 0.7 10.4 10.6 8.1e+02 0.5 10.6 2.9 1 1 0 1 1 1 0 D-ala D-ala ligase N-terminus RskA PF10099.9 CDI79998.1 - 0.46 10.8 22.2 0.92 9.8 2.7 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI79998.1 - 0.64 10.1 26.2 0.56 10.3 6.9 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Ribosomal_60s PF00428.19 CDI79998.1 - 3.1 8.4 13.8 5.4 7.7 6.4 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Myb_DNA-binding PF00249.31 CDI80017.1 - 7.6e-12 45.2 0.0 1.4e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM-assoc_1 PF16495.5 CDI80017.1 - 9.8e-11 41.5 6.7 9.8e-11 41.5 6.7 3.0 3 0 0 3 3 2 1 SWIRM-associated region 1 Myb_DNA-bind_6 PF13921.6 CDI80017.1 - 2.9e-07 30.6 0.0 5.4e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Velvet PF11754.8 CDI80017.1 - 0.0023 17.9 2.3 0.0031 17.5 2.3 1.4 1 0 0 1 1 1 1 Velvet factor SOG2 PF10428.9 CDI80017.1 - 0.032 13.4 16.1 0.038 13.2 16.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF966 PF06136.13 CDI80017.1 - 0.06 13.1 11.6 0.074 12.8 11.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) BAF1_ABF1 PF04684.13 CDI80017.1 - 0.12 11.5 9.9 0.15 11.1 9.9 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Apt1 PF10351.9 CDI80017.1 - 0.13 11.1 10.2 0.18 10.6 10.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 CDI80017.1 - 0.15 10.8 5.2 0.2 10.4 5.2 1.3 1 0 0 1 1 1 0 Presenilin Lin-8 PF03353.15 CDI80017.1 - 0.34 10.4 9.6 0.65 9.5 9.6 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Mcm10 PF09332.11 CDI80017.1 - 0.55 9.6 9.8 0.92 8.9 9.8 1.3 1 0 0 1 1 1 0 Mcm10 replication factor PPP4R2 PF09184.11 CDI80017.1 - 0.74 9.4 6.5 0.98 8.9 6.5 1.2 1 0 0 1 1 1 0 PPP4R2 TMEM247 PF15444.6 CDI80017.1 - 2.2 8.3 9.8 0.33 11.0 1.3 2.2 1 1 1 2 2 2 0 Transmembrane protein 247 Peptidase_S64 PF08192.11 CDI80017.1 - 4.9 5.5 16.7 6.5 5.1 16.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 Hid1 PF12722.7 CDI80017.1 - 5.7 4.9 8.5 7.1 4.6 8.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CDI80017.1 - 5.8 3.9 15.4 7.3 3.6 15.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SWI-SNF_Ssr4 PF08549.10 CDI80017.1 - 7.7 5.0 15.6 5.7 5.5 11.7 1.9 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) RRM_1 PF00076.22 CDI80030.1 - 1.6e-14 53.5 0.0 2.4e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_2 PF07719.17 CDI80032.1 - 0.00042 20.2 2.4 0.24 11.6 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDI80032.1 - 0.014 15.2 0.5 0.99 9.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDI80032.1 - 0.015 15.3 0.7 0.8 9.9 0.1 3.7 1 1 1 2 2 2 0 Tetratricopeptide repeat SR-25 PF10500.9 CDI80043.1 - 9.6e-07 28.6 73.6 8.5e-06 25.5 11.4 3.9 3 1 1 4 4 4 3 Nuclear RNA-splicing-associated protein AAA_32 PF13654.6 CDI80043.1 - 9.1 4.9 15.7 14 4.3 15.7 1.2 1 0 0 1 1 1 0 AAA domain V_ATPase_I PF01496.19 CDI80049.1 - 0.44 8.4 22.6 0.45 8.4 22.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF913 PF06025.12 CDI80049.1 - 1.4 7.8 13.6 1.4 7.8 13.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FHIPEP PF00771.20 CDI80049.1 - 1.6 7.1 14.3 1.8 6.9 14.3 1.2 1 0 0 1 1 1 0 FHIPEP family CobT PF06213.12 CDI80049.1 - 2.2 7.6 30.6 2.4 7.5 30.6 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF1180 PF06679.12 CDI80049.1 - 2.5 8.5 11.2 2.9 8.3 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Pex14_N PF04695.13 CDI80049.1 - 2.5 8.8 34.2 2.7 8.6 34.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Connexin PF00029.19 CDI80049.1 - 2.6 7.7 17.3 2.9 7.6 17.3 1.1 1 0 0 1 1 1 0 Connexin CLN3 PF02487.17 CDI80049.1 - 2.8 6.9 18.0 2.9 6.9 18.0 1.0 1 0 0 1 1 1 0 CLN3 protein SID-1_RNA_chan PF13965.6 CDI80049.1 - 3.4 6.0 11.8 3.4 6.0 11.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CPSF100_C PF13299.6 CDI80049.1 - 3.5 7.8 17.0 3.7 7.7 17.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CBP_BcsG PF11658.8 CDI80049.1 - 4.1 5.7 20.8 4.5 5.5 20.8 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Presenilin PF01080.17 CDI80049.1 - 4.2 6.0 25.5 4.4 6.0 25.5 1.0 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI80049.1 - 4.3 7.1 20.8 4.4 7.0 20.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ureide_permease PF07168.11 CDI80049.1 - 4.5 5.9 9.4 4.6 5.9 9.4 1.1 1 0 0 1 1 1 0 Ureide permease MDM10 PF12519.8 CDI80049.1 - 4.6 6.0 18.4 5 5.9 18.4 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SpoIIP PF07454.11 CDI80049.1 - 5.3 6.4 24.7 5.6 6.3 24.7 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Ketoacyl-synt_2 PF13723.6 CDI80049.1 - 5.9 6.5 23.6 6.2 6.4 23.6 1.0 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain eIF-3_zeta PF05091.12 CDI80049.1 - 6.7 5.6 29.1 6.8 5.5 29.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PIP5K PF01504.18 CDI80049.1 - 7.2 5.7 20.1 7.5 5.7 20.1 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Gti1_Pac2 PF09729.9 CDI80049.1 - 8.3 6.5 18.5 9 6.4 18.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family UPF0565 PF10561.9 CDI80049.1 - 9.6 5.3 16.2 11 5.1 16.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 ADP_ribosyl_GH PF03747.14 CDI80050.1 - 0.13 12.0 10.5 0.15 11.8 10.5 1.1 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase MAP7 PF05672.11 CDI80050.1 - 0.2 11.4 40.3 0.27 10.9 40.3 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family SurE PF01975.17 CDI80050.1 - 0.32 10.7 6.7 0.55 10.0 6.7 1.5 1 1 0 1 1 1 0 Survival protein SurE FAM60A PF15396.6 CDI80050.1 - 0.41 10.6 20.9 0.54 10.2 20.9 1.3 1 0 0 1 1 1 0 Protein Family FAM60A DUF3552 PF12072.8 CDI80050.1 - 0.63 9.4 33.1 0.74 9.2 33.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Activator_LAG-3 PF11498.8 CDI80050.1 - 1.4 7.8 76.5 1.5 7.7 76.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SAGA-Tad1 PF12767.7 CDI80050.1 - 1.5 8.5 25.5 1.8 8.2 25.5 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Lin-8 PF03353.15 CDI80050.1 - 4.6 6.7 28.0 5.5 6.5 28.0 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SLC12 PF03522.15 CDI80050.1 - 5.3 5.9 27.1 6.2 5.7 27.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 RIFIN PF02009.16 CDI80050.1 - 7.4 6.4 24.0 9.7 6.0 24.0 1.1 1 0 0 1 1 1 0 Rifin Miga PF10265.9 CDI80050.1 - 7.8 5.3 17.0 9.9 5.0 17.0 1.1 1 0 0 1 1 1 0 Mitoguardin DUF2052 PF09747.9 CDI80050.1 - 9.6 6.3 25.9 14 5.8 25.9 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Exonuc_VII_L PF02601.15 CDI80072.1 - 3.1 7.3 74.7 0.021 14.4 17.9 4.0 3 1 0 3 3 3 0 Exonuclease VII, large subunit DUF1754 PF08555.10 CDI80093.1 - 2.8e-05 24.8 0.3 2.8e-05 24.8 0.3 2.6 2 1 0 2 2 2 1 Eukaryotic family of unknown function (DUF1754) zf-C3HC4_2 PF13923.6 CDI80095.1 - 1.3e-06 28.2 4.2 1.3e-06 28.2 4.2 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDI80095.1 - 3.8e-05 23.6 3.7 3.8e-05 23.6 3.7 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CDI80095.1 - 4.4e-05 23.6 7.3 4.4e-05 23.6 7.3 4.3 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 CDI80095.1 - 0.00033 20.5 6.5 0.00033 20.5 6.5 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Sin_N PF04801.13 CDI80095.1 - 0.00033 20.0 11.4 0.00033 20.0 11.4 7.7 3 2 2 6 6 6 1 Sin-like protein conserved region zf-C3HC4_3 PF13920.6 CDI80095.1 - 0.0031 17.3 5.7 0.0031 17.3 5.7 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 CDI80095.1 - 0.17 11.8 6.0 0.85 9.5 4.4 2.7 2 0 0 2 2 2 0 zf-RING of BARD1-type protein TFIIA PF03153.13 CDI80096.1 - 0.00051 20.2 71.3 0.00069 19.7 71.3 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI80096.1 - 0.14 10.4 50.0 0.18 10.1 50.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1616 PF07760.11 CDI80096.1 - 1.3 8.4 12.4 1.5 8.1 12.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) V_ATPase_I PF01496.19 CDI80096.1 - 1.5 6.7 25.0 2.6 5.8 25.0 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Med15 PF09606.10 CDI80096.1 - 1.7 7.2 63.7 2.5 6.7 63.7 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CDC45 PF02724.14 CDI80096.1 - 6.1 5.0 21.8 0.24 9.6 16.3 1.6 2 0 0 2 2 2 0 CDC45-like protein PP2C PF00481.21 CDI80097.1 - 8.2e-11 42.0 15.4 3.3e-08 33.5 13.5 5.3 3 1 0 4 4 4 2 Protein phosphatase 2C RskA PF10099.9 CDI80097.1 - 0.0028 18.0 30.5 0.0072 16.6 21.9 9.8 1 1 7 9 9 9 4 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI80097.1 - 0.7 8.8 0.0 0.7 8.8 0.0 8.3 4 2 3 8 8 8 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI80111.1 - 0.014 15.0 13.0 0.02 14.5 13.0 1.2 1 0 0 1 1 1 0 Spt20 family Coilin_N PF15862.5 CDI80111.1 - 0.052 13.4 6.2 0.063 13.1 6.2 1.3 1 0 0 1 1 1 0 Coilin N-terminus PA26 PF04636.13 CDI80111.1 - 0.11 11.3 2.2 0.12 11.2 2.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Neur_chan_memb PF02932.16 CDI80111.1 - 0.15 12.1 3.9 0.19 11.8 3.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TFIIA PF03153.13 CDI80111.1 - 0.44 10.5 26.2 0.59 10.1 26.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI80111.1 - 0.61 8.8 8.1 0.64 8.7 8.1 1.2 1 0 0 1 1 1 0 Presenilin DUF4820 PF16091.5 CDI80111.1 - 1.1 8.6 7.9 1.7 7.9 7.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) RR_TM4-6 PF06459.12 CDI80111.1 - 1.2 8.9 7.8 1.3 8.8 7.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Serinc PF03348.15 CDI80111.1 - 1.4 7.7 4.0 1.7 7.4 4.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Plasmodium_Vir PF05795.11 CDI80111.1 - 2.1 7.7 4.9 2.6 7.4 4.9 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF4770 PF15994.5 CDI80111.1 - 2.1 8.5 7.4 3.1 8.0 4.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Hamartin PF04388.12 CDI80111.1 - 2.5 6.7 14.8 3 6.4 14.8 1.2 1 0 0 1 1 1 0 Hamartin protein SR-25 PF10500.9 CDI80111.1 - 4.2 6.9 30.1 0.059 13.0 14.6 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Hid1 PF12722.7 CDI80111.1 - 5.6 5.0 8.6 5.6 5.0 8.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CCSAP PF15748.5 CDI80111.1 - 6.5 6.9 20.4 8.2 6.5 20.4 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated TFIIA PF03153.13 CDI80112.1 - 3.7 7.4 24.7 4.5 7.2 24.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TFIIA PF03153.13 CDI80113.1 - 0.55 10.2 20.2 0.7 9.8 20.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI80113.1 - 4.1 7.6 34.5 1.6 8.8 10.4 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF4834 PF16118.5 CDI80125.1 - 3.1e-05 24.9 0.1 3.1e-05 24.9 0.1 7.2 4 1 2 6 6 5 2 Domain of unknown function (DUF4834) Pex24p PF06398.11 CDI80125.1 - 0.0025 16.8 0.3 0.0025 16.8 0.3 3.6 3 1 0 3 3 3 1 Integral peroxisomal membrane peroxin DUF755 PF05501.11 CDI80125.1 - 0.0048 17.2 7.4 0.0048 17.2 7.4 7.3 6 1 1 7 7 4 1 Domain of unknown function (DUF755) RskA PF10099.9 CDI80125.1 - 0.0061 16.9 6.0 0.0061 16.9 6.0 7.1 1 1 5 7 7 5 2 Anti-sigma-K factor rskA DUF3742 PF12553.8 CDI80125.1 - 0.011 15.9 1.9 0.096 12.8 0.0 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3742) CitMHS PF03600.16 CDI80125.1 - 0.012 14.9 0.0 0.098 11.8 0.0 2.1 2 1 0 3 3 3 0 Citrate transporter JUPITER PF17054.5 CDI80125.1 - 0.029 13.8 5.9 0.074 12.5 5.2 2.0 2 0 0 2 2 2 0 Microtubule-Associated protein Jupiter Pilin_N PF07790.11 CDI80125.1 - 0.041 14.8 0.1 0.041 14.8 0.1 3.9 5 0 0 5 5 1 0 Archaeal Type IV pilin, N-terminal O-antigen_lig PF13425.6 CDI80125.1 - 0.068 11.9 0.1 0.068 11.9 0.1 3.7 4 1 0 4 4 3 0 O-antigen ligase like membrane protein SARAF PF06682.12 CDI80125.1 - 1.5 8.4 45.8 0.023 14.3 4.5 4.9 2 2 1 4 4 4 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2207 PF09972.9 CDI80125.1 - 2.2 7.0 5.8 6.9 5.3 0.0 3.5 4 1 0 4 4 4 0 Predicted membrane protein (DUF2207) Utp14 PF04615.13 CDI80125.1 - 3.5 6.1 47.2 2.4 6.6 22.5 2.4 2 0 0 2 2 2 0 Utp14 protein DUF2722 PF10846.8 CDI80125.1 - 6.2 5.7 126.6 0.031 13.2 6.8 6.3 6 0 0 6 6 6 0 Protein of unknown function (DUF2722) SDA1 PF05285.12 CDI80129.1 - 0.016 14.6 23.6 0.019 14.4 23.6 1.0 1 0 0 1 1 1 0 SDA1 MMR1 PF08505.10 CDI80129.1 - 0.042 14.1 40.6 0.046 14.0 40.6 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Nop53 PF07767.11 CDI80129.1 - 0.048 13.1 30.3 0.055 12.9 30.3 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CKAP2_C PF15297.6 CDI80129.1 - 0.18 10.8 21.0 0.21 10.6 21.0 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus DUF4746 PF15928.5 CDI80129.1 - 0.19 11.2 15.2 0.21 11.0 15.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TFIIA PF03153.13 CDI80129.1 - 0.2 11.6 55.3 0.31 11.0 55.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Borrelia_P83 PF05262.11 CDI80129.1 - 0.24 9.9 21.5 0.26 9.7 21.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein CCSAP PF15748.5 CDI80129.1 - 0.36 11.0 42.2 0.45 10.6 42.2 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4407 PF14362.6 CDI80129.1 - 0.4 10.0 22.8 0.52 9.6 22.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peptidase_S15 PF02129.18 CDI80129.1 - 0.48 10.0 14.0 0.55 9.8 14.0 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF4175 PF13779.6 CDI80129.1 - 0.49 8.2 45.4 0.51 8.2 45.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) NARP1 PF12569.8 CDI80129.1 - 0.58 9.0 22.5 0.64 8.9 22.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Dsh_C PF12316.8 CDI80129.1 - 0.6 10.5 33.1 0.73 10.2 33.1 1.0 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal eIF-3_zeta PF05091.12 CDI80129.1 - 1.2 8.0 33.3 1.4 7.8 33.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CDK5_activator PF03261.15 CDI80129.1 - 1.2 8.6 30.2 1.3 8.5 30.2 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein SOBP PF15279.6 CDI80129.1 - 2.1 8.9 35.4 2.4 8.7 35.4 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein DUF2828 PF11443.8 CDI80129.1 - 2.5 6.1 23.4 2.7 6.0 23.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF5523 PF17661.1 CDI80129.1 - 3.2 7.4 27.7 4.3 7.0 27.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Presenilin PF01080.17 CDI80129.1 - 3.5 6.3 39.5 4.6 5.9 39.5 1.2 1 0 0 1 1 1 0 Presenilin Endostatin PF06482.11 CDI80129.1 - 3.5 7.0 29.4 4.2 6.8 29.4 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Hid1 PF12722.7 CDI80129.1 - 3.7 5.6 40.3 4.4 5.3 40.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4638 PF15472.6 CDI80129.1 - 3.8 7.2 21.2 4.6 6.9 21.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) CAC1F_C PF16885.5 CDI80129.1 - 3.9 7.0 23.6 4.2 6.9 23.6 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term LAP1C PF05609.12 CDI80129.1 - 4.1 6.4 35.9 4.5 6.2 35.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PAT1 PF09770.9 CDI80129.1 - 4.1 5.6 41.4 4.5 5.4 41.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PepSY_TM PF03929.16 CDI80129.1 - 4.2 7.0 11.8 4.8 6.7 11.8 1.2 1 0 0 1 1 1 0 PepSY-associated TM region GREB1 PF15782.5 CDI80129.1 - 4.2 4.3 39.4 5 4.1 39.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2126 PF09899.9 CDI80129.1 - 4.6 5.2 16.8 5 5.1 16.8 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF966 PF06136.13 CDI80129.1 - 4.7 6.8 34.2 5.7 6.6 34.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) MCM_bind PF09739.9 CDI80129.1 - 4.8 5.5 30.4 5.6 5.3 30.4 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor RR_TM4-6 PF06459.12 CDI80129.1 - 5.1 6.8 32.7 6.3 6.5 32.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GNT-I PF03071.15 CDI80129.1 - 5.6 5.6 14.0 6.9 5.3 14.0 1.3 1 0 0 1 1 1 0 GNT-I family Cellulose_synt PF03552.14 CDI80129.1 - 5.7 5.3 12.0 6.2 5.2 12.0 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF4471 PF14740.6 CDI80129.1 - 6.1 6.0 20.3 7.3 5.7 20.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) MRP-S26 PF14943.6 CDI80129.1 - 6.5 6.6 28.3 8.2 6.3 28.3 1.1 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 SR-25 PF10500.9 CDI80129.1 - 7 6.2 52.3 1.9 8.0 39.1 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein TCP PF03634.13 CDI80129.1 - 7.7 7.1 38.4 10 6.6 38.4 1.2 1 0 0 1 1 1 0 TCP family transcription factor DUF853 PF05872.12 CDI80129.1 - 9.7 4.6 20.1 11 4.5 20.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Kelch_6 PF13964.6 CDI80145.1 - 2.4e-10 40.3 0.6 0.0017 18.5 0.0 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 CDI80145.1 - 5.2e-09 36.2 2.1 3.5e-05 24.0 0.2 4.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 CDI80145.1 - 1.1e-08 34.5 6.1 1.7e-06 27.5 0.1 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 CDI80145.1 - 2.2e-08 33.9 4.1 0.001 19.1 0.0 4.6 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 CDI80145.1 - 1.7e-07 31.0 2.7 0.0034 17.3 1.8 3.7 3 1 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 CDI80145.1 - 6.3e-06 26.1 0.1 0.00023 21.1 0.1 2.8 2 0 0 2 2 2 1 Kelch motif DUF572 PF04502.13 CDI80145.1 - 0.0055 16.4 4.8 0.0055 16.4 4.8 3.7 3 1 0 3 3 3 1 Family of unknown function (DUF572) eIF-3_zeta PF05091.12 CDI80178.1 - 0.013 14.5 13.7 0.015 14.3 13.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spt20 PF12090.8 CDI80178.1 - 0.32 10.6 40.9 0.091 12.4 37.8 1.7 2 0 0 2 2 2 0 Spt20 family CSG2 PF16965.5 CDI80178.1 - 0.42 9.5 6.0 0.43 9.5 6.0 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator SID-1_RNA_chan PF13965.6 CDI80178.1 - 0.49 8.8 5.9 0.51 8.7 5.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 AAA_23 PF13476.6 CDI80178.1 - 1.1 9.7 20.0 1.4 9.4 20.0 1.2 1 0 0 1 1 1 0 AAA domain Connexin PF00029.19 CDI80178.1 - 2.1 8.0 12.4 3.1 7.5 12.4 1.3 1 0 0 1 1 1 0 Connexin SpoIIP PF07454.11 CDI80178.1 - 2.9 7.3 19.9 5.2 6.5 19.9 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) LMBR1 PF04791.16 CDI80178.1 - 3.4 6.5 6.9 3.1 6.6 6.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein YjbH PF06082.11 CDI80178.1 - 3.8 6.2 22.0 4.8 5.9 22.0 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH TFB6 PF17110.5 CDI80178.1 - 4.4 7.0 10.9 7.1 6.3 10.9 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH HCO3_cotransp PF00955.21 CDI80178.1 - 5 5.8 8.9 6.6 5.4 8.9 1.1 1 0 0 1 1 1 0 HCO3- transporter family V_ATPase_I PF01496.19 CDI80178.1 - 5.3 4.8 17.0 6.8 4.5 17.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FAM176 PF14851.6 CDI80178.1 - 7.2 6.3 14.9 18 5.0 14.9 1.6 1 0 0 1 1 1 0 FAM176 family Membralin PF09746.9 CDI80178.1 - 8.5 5.3 12.0 11 5.0 12.0 1.2 1 0 0 1 1 1 0 Tumour-associated protein PAT1 PF09770.9 CDI80178.1 - 8.7 4.5 29.7 11 4.2 29.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AMMECR1 PF01871.17 CDI80209.1 - 3.2e-07 30.1 0.0 3.2e-07 30.1 0.0 2.1 3 0 0 3 3 3 1 AMMECR1 TMEM151 PF14857.6 CDI80209.1 - 0.1 11.5 13.1 0.13 11.2 13.1 1.1 1 0 0 1 1 1 0 TMEM151 family DUF4692 PF15763.5 CDI80209.1 - 0.21 12.1 8.3 0.4 11.1 8.3 1.5 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Sporozoite_P67 PF05642.11 CDI80209.1 - 0.44 8.6 4.5 0.73 7.8 4.5 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RAP1 PF07218.11 CDI80209.1 - 1.6 6.9 5.2 2 6.6 5.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Macoilin PF09726.9 CDI80209.1 - 1.8 7.0 24.4 2.8 6.4 24.4 1.3 1 0 0 1 1 1 0 Macoilin family DUF3138 PF11336.8 CDI80209.1 - 2.3 6.7 7.8 0.74 8.4 4.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) RR_TM4-6 PF06459.12 CDI80209.1 - 6.6 6.5 15.2 8.2 6.2 15.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4045 PF13254.6 CDI80212.1 - 1.7 8.2 23.8 2 8.0 23.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CDC45 PF02724.14 CDI80212.1 - 2.7 6.2 27.2 3.2 6.0 27.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI80212.1 - 3.5 6.3 37.1 4.2 6.0 37.1 1.0 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI80212.1 - 6.7 6.7 25.6 8.5 6.3 25.6 1.0 1 0 0 1 1 1 0 Protein Family FAM60A AUX_IAA PF02309.16 CDI80212.1 - 7.3 6.4 23.5 9 6.1 23.5 1.0 1 0 0 1 1 1 0 AUX/IAA family SLC12 PF03522.15 CDI80212.1 - 8.2 5.3 32.3 9.3 5.1 32.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF572 PF04502.13 CDI80212.1 - 8.6 5.9 26.2 11 5.6 26.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4834 PF16118.5 CDI80226.1 - 0.0081 17.1 4.9 0.0081 17.1 4.9 12.8 2 2 3 5 5 5 1 Domain of unknown function (DUF4834) Pkinase PF00069.25 CDI80231.1 - 1.5e-57 195.0 0.0 1.8e-57 194.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80231.1 - 4.4e-32 111.4 0.0 5.5e-32 111.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI80231.1 - 1.5e-08 34.4 0.0 1.8e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDI80231.1 - 2.4e-05 23.8 0.1 3e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDI80231.1 - 0.00045 19.3 0.2 0.00053 19.0 0.2 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDI80231.1 - 0.0013 18.7 1.0 0.0094 15.9 1.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDI80231.1 - 0.0016 18.1 0.2 0.0021 17.7 0.2 1.1 1 0 0 1 1 1 1 RIO1 family YukC PF10140.9 CDI80231.1 - 0.018 13.9 0.0 0.022 13.6 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Choline_kinase PF01633.20 CDI80231.1 - 0.048 13.3 0.1 0.057 13.0 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Glucan_synthase PF02364.15 CDI80237.1 - 3.9e-135 452.0 1.4 3.1e-113 379.6 4.8 2.5 2 0 0 2 2 2 2 1,3-beta-glucan synthase component Glyco_trans_2_3 PF13632.6 CDI80237.1 - 0.061 13.2 0.2 0.061 13.2 0.2 2.4 2 0 0 2 2 2 0 Glycosyl transferase family group 2 Pex14_N PF04695.13 CDI80244.1 - 0.0053 17.4 21.2 0.0053 17.4 21.2 5.2 3 1 1 4 4 4 1 Peroxisomal membrane anchor protein (Pex14p) conserved region EPL1 PF10513.9 CDI80244.1 - 6.1 7.2 45.3 4.2 7.7 4.2 4.2 4 0 0 4 4 4 0 Enhancer of polycomb-like SelP_N PF04592.14 CDI80248.1 - 1.1 8.6 38.1 1.2 8.5 38.1 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF1075 PF06388.11 CDI80248.1 - 1.5 8.9 12.2 1.7 8.7 12.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) Nitroreductase PF00881.24 CDI80249.1 - 0.067 13.2 6.6 0.085 12.9 6.6 1.2 1 0 0 1 1 1 0 Nitroreductase family Gti1_Pac2 PF09729.9 CDI80249.1 - 0.074 13.1 8.6 0.09 12.9 8.6 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family TFIIA PF03153.13 CDI80249.1 - 0.1 12.6 35.2 0.13 12.2 35.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ferlin_C PF16165.5 CDI80249.1 - 0.29 11.1 2.0 0.33 10.9 2.0 1.1 1 0 0 1 1 1 0 Ferlin C-terminus DUF3881 PF12997.7 CDI80249.1 - 0.29 10.3 5.5 0.39 9.9 5.5 1.3 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3881) Presenilin PF01080.17 CDI80249.1 - 0.29 9.9 16.5 0.34 9.6 16.5 1.0 1 0 0 1 1 1 0 Presenilin ANXA2R PF15721.5 CDI80249.1 - 0.71 10.4 14.0 0.82 10.2 14.0 1.1 1 0 0 1 1 1 0 Annexin-2 receptor Sec62 PF03839.16 CDI80249.1 - 2.8 7.4 12.4 3.6 7.0 12.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 FAM60A PF15396.6 CDI80249.1 - 4 7.4 9.5 5.2 7.0 9.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SLC12 PF03522.15 CDI80249.1 - 4.4 6.2 13.8 4.9 6.1 13.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Asp-B-Hydro_N PF05279.11 CDI80249.1 - 5 7.1 10.4 5.7 6.9 10.4 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Ofd1_CTDD PF10637.9 CDI80249.1 - 5.1 6.4 9.0 5.7 6.2 9.0 1.1 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term PAT1 PF09770.9 CDI80249.1 - 5.5 5.1 27.8 6.3 4.9 27.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 CDI80249.1 - 5.9 6.9 12.0 7 6.6 12.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GET2 PF08690.10 CDI80249.1 - 6.9 6.3 17.7 8.7 5.9 17.7 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Hid1 PF12722.7 CDI80249.1 - 7.7 4.5 12.8 8.4 4.4 12.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Membralin PF09746.9 CDI80249.1 - 7.7 5.4 7.7 8.4 5.3 7.7 1.0 1 0 0 1 1 1 0 Tumour-associated protein Ndc1_Nup PF09531.10 CDI80249.1 - 8.3 5.0 11.8 9.2 4.8 11.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup 2OG-FeII_Oxy_5 PF13759.6 CDI80249.1 - 8.4 6.9 8.9 13 6.3 7.2 1.9 1 1 1 2 2 2 0 Putative 2OG-Fe(II) oxygenase MDM10 PF12519.8 CDI80249.1 - 8.9 5.0 9.5 9.9 4.9 9.5 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 RskA PF10099.9 CDI80256.1 - 0.021 15.1 0.3 0.021 15.1 0.3 7.4 2 2 3 5 5 5 0 Anti-sigma-K factor rskA FAM176 PF14851.6 CDI80256.1 - 0.031 13.9 0.2 0.031 13.9 0.2 4.6 3 1 1 4 4 4 0 FAM176 family DUF913 PF06025.12 CDI80256.1 - 0.2 10.6 34.1 0.15 11.0 6.6 4.0 4 0 0 4 4 4 0 Domain of Unknown Function (DUF913) Striatin PF08232.12 CDI80256.1 - 0.83 10.2 54.1 2.5 8.7 6.0 4.4 4 0 0 4 4 4 0 Striatin family SLC12 PF03522.15 CDI80256.1 - 1.9 7.4 44.6 0.33 9.9 2.8 3.9 4 0 0 4 4 4 0 Solute carrier family 12 eIF-3_zeta PF05091.12 CDI80266.1 - 0.00065 18.8 9.1 0.00065 18.8 9.1 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GET2 PF08690.10 CDI80266.1 - 0.025 14.3 19.2 0.033 13.9 19.2 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 TFIIA PF03153.13 CDI80266.1 - 0.12 12.4 43.0 0.17 11.9 43.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI80266.1 - 0.2 9.9 22.5 0.22 9.8 22.5 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GAGA_bind PF06217.12 CDI80266.1 - 0.61 10.3 10.7 0.77 10.0 10.7 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family V_ATPase_I PF01496.19 CDI80266.1 - 0.64 7.9 9.3 0.86 7.4 9.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RPA43_OB PF17875.1 CDI80266.1 - 1.4 9.5 12.7 0.33 11.6 7.3 2.1 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Connexin PF00029.19 CDI80266.1 - 1.5 8.5 8.4 0.21 11.3 4.8 1.5 2 0 0 2 2 2 0 Connexin PIP5K PF01504.18 CDI80266.1 - 1.7 7.8 15.9 2 7.6 15.1 1.4 1 1 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Folate_carrier PF01770.18 CDI80266.1 - 2.4 6.8 5.0 3.3 6.3 5.0 1.2 1 0 0 1 1 1 0 Reduced folate carrier SARAF PF06682.12 CDI80266.1 - 2.6 7.6 14.1 0.041 13.5 6.7 1.7 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis tRNA_synt_1c_R2 PF04557.15 CDI80266.1 - 2.7 9.0 13.4 8.3 7.4 7.9 2.5 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DUF1980 PF09323.10 CDI80266.1 - 3.3 7.6 7.0 5.4 6.9 7.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Het-C PF07217.11 CDI80266.1 - 6.9 5.1 10.5 9.3 4.6 10.5 1.3 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF2722 PF10846.8 CDI80269.1 - 2.1e-06 27.0 7.2 2.1e-06 27.0 7.2 5.9 6 0 0 6 6 6 2 Protein of unknown function (DUF2722) RskA PF10099.9 CDI80269.1 - 0.0073 16.6 22.5 0.0073 16.6 22.5 9.7 1 1 4 5 5 5 1 Anti-sigma-K factor rskA Beta-lactamase PF00144.24 CDI80271.1 - 0.22 10.7 6.9 0.057 12.7 3.8 1.4 1 1 0 1 1 1 0 Beta-lactamase DUF4667 PF15700.5 CDI80272.1 - 0.02 15.0 5.4 0.022 14.9 5.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) DUF4400 PF14348.6 CDI80272.1 - 0.21 11.1 2.9 0.25 10.8 2.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) Bindin PF02084.15 CDI80272.1 - 0.56 10.4 6.6 0.61 10.3 6.6 1.0 1 0 0 1 1 1 0 Bindin BAF1_ABF1 PF04684.13 CDI80272.1 - 0.76 8.8 2.8 0.84 8.6 2.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Ribosomal_60s PF00428.19 CDI80272.1 - 0.99 10.0 12.6 1.6 9.3 12.6 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein RAP1 PF07218.11 CDI80272.1 - 4.3 5.5 8.5 4.7 5.4 8.5 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) MSA-2c PF12238.8 CDI80272.1 - 7.6 6.5 9.0 7.8 6.4 9.0 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF4179 PF13786.6 CDI80272.1 - 9.8 6.7 8.1 26 5.4 8.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) DUF4820 PF16091.5 CDI80273.1 - 0.0028 17.0 10.3 0.0033 16.8 10.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4820) DUF2681 PF10883.8 CDI80273.1 - 0.014 15.8 7.9 0.014 15.8 7.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Usp PF00582.26 CDI80273.1 - 0.032 14.8 0.2 0.032 14.8 0.2 1.6 2 0 0 2 2 2 0 Universal stress protein family Pannexin_like PF12534.8 CDI80273.1 - 0.17 11.0 7.9 0.2 10.7 7.9 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Peptidase_S49_N PF08496.10 CDI80273.1 - 0.19 11.8 6.1 0.17 11.9 1.7 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal PAS PF00989.25 CDI80273.1 - 0.29 11.1 5.8 2.5 8.1 0.2 2.1 2 0 0 2 2 2 0 PAS fold SLC12 PF03522.15 CDI80273.1 - 0.42 9.6 10.0 0.53 9.2 10.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 V_ATPase_I PF01496.19 CDI80273.1 - 0.49 8.2 8.8 0.53 8.1 8.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2126 PF09899.9 CDI80273.1 - 0.53 8.3 8.0 0.56 8.2 8.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) PIP5K PF01504.18 CDI80273.1 - 0.53 9.5 5.1 0.71 9.0 5.1 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase XK-related PF09815.9 CDI80273.1 - 0.82 8.7 1.7 0.96 8.4 1.7 1.1 1 0 0 1 1 1 0 XK-related protein DUF4407 PF14362.6 CDI80273.1 - 0.98 8.7 12.8 1.5 8.1 12.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SID-1_RNA_chan PF13965.6 CDI80273.1 - 1.3 7.3 2.9 1.5 7.1 2.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 CDI80273.1 - 1.5 7.7 5.0 2 7.3 5.0 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Neur_chan_memb PF02932.16 CDI80273.1 - 2.6 8.0 9.2 3.2 7.7 9.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PSCyt3 PF07627.11 CDI80273.1 - 2.8 8.3 9.5 2.5 8.4 6.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1588) Dicty_REP PF05086.12 CDI80273.1 - 3.1 5.7 11.9 4.5 5.1 11.9 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3043 PF11241.8 CDI80273.1 - 3.5 7.6 11.2 2.3 8.2 5.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) Eapp_C PF10238.9 CDI80273.1 - 4.3 7.4 11.7 9.6 6.3 7.5 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF4770 PF15994.5 CDI80273.1 - 4.8 7.4 15.8 0.51 10.5 5.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Sec62 PF03839.16 CDI80273.1 - 6.4 6.2 7.2 6.5 6.2 4.3 1.9 2 0 0 2 2 2 0 Translocation protein Sec62 RICTOR_N PF14664.6 CDI80273.1 - 6.4 5.7 6.3 0.97 8.4 2.6 1.5 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term Orf78 PF06024.12 CDI80273.1 - 6.5 7.1 7.6 20 5.5 4.1 2.2 2 0 0 2 2 2 0 Orf78 (ac78) FAM176 PF14851.6 CDI80273.1 - 7.1 6.3 9.0 0.71 9.5 3.2 1.9 2 0 0 2 2 2 0 FAM176 family DUF1644 PF07800.12 CDI80273.1 - 8.7 6.4 10.4 19 5.3 4.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) Folate_carrier PF01770.18 CDI80273.1 - 9 4.9 6.6 1.2 7.7 3.0 1.5 1 1 1 2 2 2 0 Reduced folate carrier FHIPEP PF00771.20 CDI80273.1 - 9.5 4.5 10.0 14 4.0 10.0 1.4 1 1 0 1 1 1 0 FHIPEP family Spt20 PF12090.8 CDI80289.1 - 0.0014 18.3 9.3 0.0014 18.3 9.3 5.9 4 2 1 5 5 5 1 Spt20 family CDC45 PF02724.14 CDI80289.1 - 0.002 16.5 14.8 0.002 16.5 14.8 3.2 3 0 0 3 3 3 1 CDC45-like protein DUF2722 PF10846.8 CDI80289.1 - 0.0041 16.1 7.7 0.0041 16.1 7.7 6.3 4 2 2 6 6 6 1 Protein of unknown function (DUF2722) CCDC53 PF10152.9 CDI80289.1 - 0.016 15.6 16.7 0.016 15.6 16.7 6.9 2 1 2 4 4 4 0 Subunit CCDC53 of WASH complex RIC3 PF15361.6 CDI80289.1 - 0.043 14.2 0.4 0.043 14.2 0.4 4.6 4 1 0 4 4 4 0 Resistance to inhibitors of cholinesterase homologue 3 Phage_Gp15 PF06854.11 CDI80289.1 - 0.083 12.9 0.1 0.083 12.9 0.1 4.2 3 1 0 3 3 3 0 Bacteriophage Gp15 protein MFS_1_like PF12832.7 CDI80289.1 - 0.8 8.5 1.9 1 8.1 0.1 1.9 2 0 0 2 2 2 0 MFS_1 like family TFIIA PF03153.13 CDI80290.1 - 0.00021 21.5 37.5 0.00031 20.9 37.5 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI80290.1 - 0.00049 20.4 4.9 0.0008 19.7 4.6 1.4 1 1 0 1 1 1 1 Anti-sigma-K factor rskA DUF5134 PF17197.4 CDI80290.1 - 0.0015 18.5 1.6 0.002 18.1 1.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5134) BAF1_ABF1 PF04684.13 CDI80290.1 - 0.0091 15.1 6.3 0.0091 15.1 6.3 2.1 2 0 0 2 2 2 1 BAF1 / ABF1 chromatin reorganising factor FHIPEP PF00771.20 CDI80290.1 - 0.036 12.6 1.1 0.042 12.3 1.1 1.2 1 0 0 1 1 1 0 FHIPEP family DUF4407 PF14362.6 CDI80290.1 - 0.49 9.7 5.9 0.9 8.8 5.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4175 PF13779.6 CDI80290.1 - 0.91 7.4 21.5 1.3 6.8 21.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CbtA PF09490.10 CDI80290.1 - 1.5 8.5 6.8 2.1 8.0 6.8 1.3 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) Ribosomal_60s PF00428.19 CDI80290.1 - 4.5 7.9 8.6 0.33 11.6 3.4 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein NicO PF03824.16 CDI80290.1 - 6.2 6.1 6.4 8.5 5.6 6.4 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein HEAT_2 PF13646.6 CDI80295.1 - 0.17 12.3 8.7 1.4 9.4 0.7 3.0 2 1 1 3 3 3 0 HEAT repeats Herpes_capsid PF06112.11 CDI80295.1 - 0.52 10.4 8.6 0.89 9.6 8.6 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein tRNA-synt_2b PF00587.25 CDI80303.1 - 3.7e-25 88.9 0.0 6.1e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Glycos_transf_1 PF00534.20 CDI80304.1 - 3.4e-20 72.3 0.0 4.2e-09 36.2 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDI80304.1 - 1e-08 35.7 0.0 2.9e-07 31.0 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CDI80304.1 - 0.0078 16.6 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Vps51 PF08700.11 CDI80310.1 - 0.00022 21.2 0.0 0.00055 20.0 0.0 1.6 1 0 0 1 1 1 1 Vps51/Vps67 MA3 PF02847.17 CDI80313.1 - 0.0036 17.3 0.2 0.012 15.6 0.2 2.0 1 1 0 1 1 1 1 MA3 domain GvpG PF05120.12 CDI80313.1 - 0.64 10.1 4.0 15 5.7 0.5 3.1 2 0 0 2 2 2 0 Gas vesicle protein G SNF2_N PF00176.23 CDI80324.1 - 1.3e-46 159.0 0.0 3.7e-46 157.5 0.0 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDI80324.1 - 4.7e-15 55.9 0.0 1.2e-14 54.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI80324.1 - 1.1e-08 35.2 0.0 2.2e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDI80324.1 - 0.00094 19.0 0.0 0.0016 18.3 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.9 CDI80324.1 - 0.0014 18.0 0.1 0.0057 15.9 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) HDA2-3 PF11496.8 CDI80324.1 - 0.0016 17.6 0.0 0.0032 16.7 0.0 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 CDI80324.1 - 0.032 13.9 0.0 0.068 12.8 0.0 1.5 1 0 0 1 1 1 0 SWI2/SNF2 ATPase EI24 PF07264.11 CDI80328.1 - 0.0076 16.5 2.8 0.013 15.7 2.8 1.4 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) RNA_GG_bind PF10258.9 CDI80331.1 - 2.9e-26 91.3 0.1 5.5e-26 90.4 0.1 1.4 1 0 0 1 1 1 1 PHAX RNA-binding domain HCV_capsid PF01543.17 CDI80331.1 - 0.89 9.8 4.4 5.4 7.2 2.3 2.3 2 0 0 2 2 2 0 Hepatitis C virus capsid protein RT_RNaseH_2 PF17919.1 CDI80337.1 - 7.7e-27 93.3 0.0 1.5e-26 92.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI80337.1 - 1.1e-25 89.9 0.0 2.2e-25 89.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDI80337.1 - 1.2e-16 60.5 0.4 2.7e-16 59.4 0.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDI80337.1 - 2.1e-13 50.5 1.0 6.8e-13 48.9 0.0 2.3 4 0 0 4 4 4 1 Integrase core domain zf-H2C2 PF09337.10 CDI80337.1 - 0.00095 19.3 0.1 0.0022 18.2 0.1 1.6 1 0 0 1 1 1 1 H2C2 zinc finger RVP_2 PF08284.11 CDI80340.1 - 4.6e-08 32.9 0.0 8e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CDI80340.1 - 5.8e-05 23.7 0.0 0.00016 22.2 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI80340.1 - 0.0012 19.4 0.0 0.004 17.7 0.0 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 CDI80340.1 - 0.0091 15.8 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 CDI80340.1 - 0.14 12.5 0.0 0.33 11.3 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC PF00098.23 CDI80340.1 - 2.1 8.6 4.3 0.78 9.9 1.0 2.1 2 0 0 2 2 2 0 Zinc knuckle ABC1 PF03109.16 CDI80344.1 - 8.7e-15 54.9 0.0 1.1e-10 41.7 0.0 2.3 2 0 0 2 2 2 2 ABC1 family ICAM_N PF03921.14 CDI80344.1 - 0.042 13.5 0.0 0.095 12.4 0.0 1.5 1 0 0 1 1 1 0 Intercellular adhesion molecule (ICAM), N-terminal domain Helicase_C PF00271.31 CDI80355.1 - 3.3e-07 30.6 0.1 8.4e-07 29.3 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI80355.1 - 0.0023 18.0 0.0 0.0051 16.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDI80355.1 - 0.0057 16.4 0.7 0.014 15.2 0.7 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_28 PF13521.6 CDI80355.1 - 0.034 14.4 1.4 5.1 7.3 0.0 3.2 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 CDI80355.1 - 0.061 13.8 0.0 0.2 12.1 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 CDI80355.1 - 0.083 13.3 1.9 0.27 11.6 0.1 2.9 3 0 0 3 3 3 0 AAA ATPase domain T2SSE PF00437.20 CDI80355.1 - 0.096 11.7 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.6 CDI80355.1 - 0.1 13.0 0.2 0.27 11.6 0.2 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CDI80355.1 - 0.65 10.5 9.0 0.16 12.5 0.7 2.6 2 0 0 2 2 2 0 AAA domain Atg14 PF10186.9 CDI80356.1 - 0.48 9.4 23.6 1.8 7.6 0.7 2.7 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fez1 PF06818.15 CDI80356.1 - 0.89 10.0 28.3 1.3 9.4 15.2 3.1 2 0 0 2 2 2 0 Fez1 Spc7 PF08317.11 CDI80356.1 - 9.3 5.0 29.4 3.6 6.4 16.6 2.9 2 1 0 2 2 2 0 Spc7 kinetochore protein PPTA PF01239.22 CDI80393.1 - 7.6e-08 31.8 0.2 0.00032 20.3 0.2 2.5 2 0 0 2 2 2 2 Protein prenyltransferase alpha subunit repeat Macoilin PF09726.9 CDI80393.1 - 0.00026 19.7 21.1 0.00026 19.7 21.1 2.3 2 0 0 2 2 2 1 Macoilin family TFIIA PF03153.13 CDI80393.1 - 0.00027 21.0 23.6 0.00027 21.0 23.6 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit SpoIIP PF07454.11 CDI80393.1 - 0.0027 17.2 37.6 0.0054 16.2 16.4 2.4 2 0 0 2 2 2 2 Stage II sporulation protein P (SpoIIP) DUF4207 PF13904.6 CDI80393.1 - 0.0027 17.4 42.6 0.0027 17.4 42.6 2.8 1 1 1 2 2 1 1 Domain of unknown function (DUF4207) CDC45 PF02724.14 CDI80393.1 - 0.0036 15.7 17.5 0.0036 15.7 17.5 2.1 2 0 0 2 2 2 1 CDC45-like protein Plasmodium_Vir PF05795.11 CDI80393.1 - 0.0067 15.9 13.3 0.0067 15.9 13.3 2.1 2 0 0 2 2 2 1 Plasmodium vivax Vir protein NUDE_C PF04880.13 CDI80393.1 - 0.01 16.4 22.2 0.01 16.4 22.2 2.4 2 0 0 2 2 1 0 NUDE protein, C-terminal conserved region DUF755 PF05501.11 CDI80393.1 - 0.014 15.7 35.5 0.014 15.7 35.5 3.8 2 1 1 3 3 2 0 Domain of unknown function (DUF755) Borrelia_P83 PF05262.11 CDI80393.1 - 0.015 13.8 32.7 0.0067 15.0 11.6 2.1 2 0 0 2 2 2 0 Borrelia P83/100 protein Connexin PF00029.19 CDI80393.1 - 0.017 14.9 27.9 0.027 14.3 14.0 2.3 2 0 0 2 2 2 0 Connexin PTPRCAP PF15713.5 CDI80393.1 - 0.036 14.4 43.8 0.65 10.3 25.4 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated CPSF100_C PF13299.6 CDI80393.1 - 0.039 14.1 36.5 0.19 11.9 9.1 2.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Isy1 PF06246.12 CDI80393.1 - 0.04 13.5 31.6 0.15 11.6 6.6 2.4 2 0 0 2 2 2 0 Isy1-like splicing family CobT PF06213.12 CDI80393.1 - 0.075 12.4 57.1 0.44 9.9 33.7 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF2052 PF09747.9 CDI80393.1 - 0.1 12.8 50.4 0.22 11.6 13.6 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Paf1 PF03985.13 CDI80393.1 - 0.2 10.7 55.4 1 8.3 32.7 2.1 2 0 0 2 2 2 0 Paf1 Lin-8 PF03353.15 CDI80393.1 - 0.27 10.7 66.7 0.14 11.7 21.6 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist FAM76 PF16046.5 CDI80393.1 - 0.3 10.4 50.4 0.26 10.6 14.5 2.3 2 0 0 2 2 2 0 FAM76 protein V_ATPase_I PF01496.19 CDI80393.1 - 0.4 8.6 43.1 0.43 8.5 22.8 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family GAGA_bind PF06217.12 CDI80393.1 - 0.45 10.7 33.7 1.1 9.5 15.2 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family Cwf_Cwc_15 PF04889.12 CDI80393.1 - 0.71 9.6 52.0 0.041 13.6 12.8 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SRP-alpha_N PF04086.13 CDI80393.1 - 0.94 9.3 50.8 2.6 7.9 17.8 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal DUF3381 PF11861.8 CDI80393.1 - 1 9.1 42.6 0.2 11.4 8.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) DUF4746 PF15928.5 CDI80393.1 - 1.1 8.7 34.0 0.97 8.8 7.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) XRN_M PF17846.1 CDI80393.1 - 1.1 8.1 33.4 0.73 8.7 14.3 2.1 2 0 0 2 2 2 0 Xrn1 helical domain DUF2151 PF10221.9 CDI80393.1 - 1.3 7.5 37.7 0.49 8.9 11.6 2.1 2 0 0 2 2 2 0 Cell cycle and development regulator Presenilin PF01080.17 CDI80393.1 - 1.6 7.4 63.6 0.44 9.3 32.3 2.1 2 0 0 2 2 2 0 Presenilin Pinin_SDK_memA PF04696.13 CDI80393.1 - 2 8.5 63.7 0.28 11.3 32.6 2.8 3 0 0 3 3 3 0 pinin/SDK/memA/ protein conserved region DUF4776 PF16003.5 CDI80393.1 - 2.1 7.3 42.1 0.65 8.9 13.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) Het-C PF07217.11 CDI80393.1 - 2.6 6.5 26.2 0.35 9.3 8.8 2.3 2 0 0 2 2 2 0 Heterokaryon incompatibility protein Het-C SLC12 PF03522.15 CDI80393.1 - 2.7 6.9 55.1 1.8 7.5 24.9 2.1 2 0 0 2 2 2 0 Solute carrier family 12 HAUS6_N PF14661.6 CDI80393.1 - 3.2 7.3 37.2 1.4 8.4 10.8 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus DUF3295 PF11702.8 CDI80393.1 - 3.2 7.0 63.8 0.63 9.3 26.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) Draxin PF15550.6 CDI80393.1 - 4.5 7.1 36.7 0.28 11.0 11.9 2.1 2 0 0 2 2 2 0 Draxin Neur_chan_memb PF02932.16 CDI80393.1 - 4.5 7.3 39.1 1.4 8.9 10.1 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Asp-B-Hydro_N PF05279.11 CDI80393.1 - 4.6 7.2 34.3 0.33 11.0 5.0 2.1 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region DUF4471 PF14740.6 CDI80393.1 - 4.6 6.4 34.9 3.3 6.9 9.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) Peptidase_S49_N PF08496.10 CDI80393.1 - 5.3 7.1 32.0 8.6 6.4 8.3 2.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal NARP1 PF12569.8 CDI80393.1 - 5.6 5.8 35.3 4.9 5.9 6.9 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 TRAP_alpha PF03896.16 CDI80393.1 - 6.3 5.9 28.1 2 7.5 13.0 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF572 PF04502.13 CDI80393.1 - 7.5 6.1 53.8 2.3 7.8 21.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) SPX PF03105.19 CDI80393.1 - 7.7 6.3 65.0 0.23 11.4 25.4 2.2 2 0 0 2 2 2 0 SPX domain SpoVR PF04293.13 CDI80393.1 - 8.2 5.0 26.1 2.8 6.5 11.6 2.1 2 0 0 2 2 2 0 SpoVR like protein PAT1 PF09770.9 CDI80393.1 - 9.8 4.3 61.0 0.13 10.6 17.2 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Thioredoxin PF00085.20 CDI80419.1 - 7.6e-30 102.9 0.0 1.2e-29 102.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CDI80419.1 - 0.00015 22.2 0.0 0.00059 20.3 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 CDI80419.1 - 0.0027 17.5 0.0 0.0042 16.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 CDI80419.1 - 0.0083 16.0 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 CDI80419.1 - 0.0088 16.1 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_8 PF13905.6 CDI80419.1 - 0.0098 16.2 0.0 0.11 12.9 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_6 PF13848.6 CDI80419.1 - 0.011 15.6 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDI80419.1 - 0.018 15.2 0.0 0.035 14.3 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like OST3_OST6 PF04756.13 CDI80419.1 - 0.032 13.6 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family HyaE PF07449.11 CDI80419.1 - 0.062 13.3 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE JAB PF01398.21 CDI80420.1 - 6.9e-12 45.4 0.0 1.2e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CDI80420.1 - 2.3e-09 37.7 0.0 3.2e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function HTH_3 PF01381.22 CDI80420.1 - 0.04 14.0 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix DUF2336 PF10098.9 CDI80420.1 - 0.19 11.1 3.4 0.34 10.3 3.4 1.4 1 1 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2336) FUSC PF04632.12 CDI80421.1 - 7.8 4.9 12.4 0.44 9.0 2.4 2.5 1 1 1 2 2 2 0 Fusaric acid resistance protein family Senescence PF06911.12 CDI80422.1 - 0.16 12.2 0.1 0.16 12.2 0.1 2.0 2 0 0 2 2 2 0 Senescence-associated protein FAM76 PF16046.5 CDI80423.1 - 0.00026 20.5 7.6 0.00042 19.8 7.6 1.3 1 0 0 1 1 1 1 FAM76 protein UPF0242 PF06785.11 CDI80423.1 - 0.0011 19.1 12.1 0.0011 19.1 12.1 2.0 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus TMF_TATA_bd PF12325.8 CDI80423.1 - 0.0025 18.0 11.3 0.0025 18.0 11.3 2.4 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding Phage_lysis PF03245.13 CDI80423.1 - 0.0036 17.4 6.1 0.0036 17.4 6.1 2.7 1 1 2 3 3 3 1 Bacteriophage Rz lysis protein AAA_13 PF13166.6 CDI80423.1 - 0.0062 15.3 5.8 0.0078 14.9 5.8 1.1 1 0 0 1 1 1 1 AAA domain BAR_2 PF10455.9 CDI80423.1 - 0.0064 15.7 6.1 0.0081 15.3 6.1 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking HMMR_N PF15905.5 CDI80423.1 - 0.012 15.1 14.8 0.018 14.5 14.8 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal CEP63 PF17045.5 CDI80423.1 - 0.013 15.4 10.8 0.013 15.4 10.8 2.1 1 1 1 2 2 2 0 Centrosomal protein of 63 kDa Exonuc_VII_L PF02601.15 CDI80423.1 - 0.021 14.4 8.5 0.026 14.1 8.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit PKcGMP_CC PF16808.5 CDI80423.1 - 0.026 14.4 2.6 0.026 14.4 2.6 3.1 2 1 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Sec34 PF04136.15 CDI80423.1 - 0.026 14.4 2.1 0.026 14.4 2.1 2.1 1 1 1 2 2 2 0 Sec34-like family Troponin PF00992.20 CDI80423.1 - 0.031 14.6 13.0 0.28 11.5 0.1 2.5 1 1 1 2 2 2 0 Troponin PA28_beta PF02252.18 CDI80423.1 - 0.052 13.2 2.2 0.12 12.0 1.1 1.9 1 1 1 2 2 2 0 Proteasome activator pa28 beta subunit Spc7 PF08317.11 CDI80423.1 - 0.076 11.9 18.1 0.21 10.4 17.5 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein ATG16 PF08614.11 CDI80423.1 - 0.085 13.1 19.7 0.31 11.3 18.8 1.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Atg14 PF10186.9 CDI80423.1 - 0.12 11.4 11.8 0.19 10.8 11.8 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cor1 PF04803.12 CDI80423.1 - 0.16 12.2 10.0 0.12 12.6 8.5 1.5 1 1 0 1 1 1 0 Cor1/Xlr/Xmr conserved region DUF4407 PF14362.6 CDI80423.1 - 0.17 11.2 16.0 1 8.6 16.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 CDI80423.1 - 0.21 11.4 19.7 2.1 8.2 8.2 3.6 3 1 1 4 4 4 0 Septum formation initiator TMF_DNA_bd PF12329.8 CDI80423.1 - 0.32 11.0 18.1 0.038 14.0 8.7 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding YabA PF06156.13 CDI80423.1 - 0.36 11.5 11.2 0.086 13.5 4.9 2.2 1 1 1 2 2 2 0 Initiation control protein YabA SlyX PF04102.12 CDI80423.1 - 0.41 11.3 21.1 0.19 12.4 3.6 4.1 1 1 3 4 4 4 0 SlyX LUC7 PF03194.15 CDI80423.1 - 0.6 9.7 10.4 1.9 8.1 10.5 1.6 1 1 0 1 1 1 0 LUC7 N_terminus Csm1_N PF18504.1 CDI80423.1 - 0.69 10.3 17.2 0.48 10.8 6.2 3.6 2 1 1 3 3 3 0 Csm1 N-terminal domain DUF2203 PF09969.9 CDI80423.1 - 0.71 10.6 13.3 2.8 8.7 2.4 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) FliJ PF02050.16 CDI80423.1 - 0.71 10.1 18.7 0.37 11.0 14.3 2.0 1 1 1 2 2 2 0 Flagellar FliJ protein SPATA24 PF15175.6 CDI80423.1 - 0.82 9.5 15.2 4.9 7.0 14.1 2.1 1 1 1 2 2 2 0 Spermatogenesis-associated protein 24 EspB_PE PF18625.1 CDI80423.1 - 0.82 10.2 0.1 0.82 10.2 0.1 3.3 3 1 1 4 4 3 0 ESX-1 secreted protein B PE domain ZapB PF06005.12 CDI80423.1 - 0.86 10.1 20.6 25 5.4 2.4 3.1 1 1 1 2 2 2 0 Cell division protein ZapB DUF1732 PF08340.11 CDI80423.1 - 0.93 9.5 6.7 0.45 10.5 2.5 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF1732) Phage_GP20 PF06810.11 CDI80423.1 - 0.94 9.3 12.5 0.5 10.2 8.8 2.0 1 1 1 2 2 2 0 Phage minor structural protein GP20 CENP-F_leu_zip PF10473.9 CDI80423.1 - 1 9.4 18.6 1.9 8.5 2.1 2.5 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Phage_Nu1 PF07471.12 CDI80423.1 - 1 9.1 7.4 1.5 8.6 5.3 2.0 1 1 1 2 2 2 0 Phage DNA packaging protein Nu1 Fez1 PF06818.15 CDI80423.1 - 1.3 9.4 15.6 6 7.3 15.6 1.9 1 1 0 1 1 1 0 Fez1 Snapin_Pallidin PF14712.6 CDI80423.1 - 1.4 9.4 15.2 0.63 10.5 4.2 2.4 1 1 1 2 2 2 0 Snapin/Pallidin DUF3740 PF12548.8 CDI80423.1 - 1.7 9.1 8.4 3.1 8.2 2.7 2.6 1 1 0 2 2 2 0 Sulfatase protein WXG100 PF06013.12 CDI80423.1 - 2.1 8.6 9.5 3.9 7.8 0.7 3.2 1 1 1 2 2 2 0 Proteins of 100 residues with WXG DUF5082 PF16888.5 CDI80423.1 - 2.9 8.2 13.0 5.1 7.4 1.3 3.0 1 1 1 3 3 3 0 Domain of unknown function (DUF5082) DUF1664 PF07889.12 CDI80423.1 - 3.1 7.8 8.2 42 4.2 8.1 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF848 PF05852.11 CDI80423.1 - 4 7.5 12.8 3.5 7.7 6.5 2.2 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) APG6_N PF17675.1 CDI80423.1 - 4.1 7.9 20.1 10 6.6 20.2 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF641 PF04859.12 CDI80423.1 - 4.4 7.6 12.3 2.1 8.7 7.2 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FlaC_arch PF05377.11 CDI80423.1 - 5 7.6 7.6 20 5.6 0.2 3.5 2 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF1003 PF06210.11 CDI80423.1 - 5.3 7.2 13.4 0.74 10.0 3.4 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1003) DivIVA PF05103.13 CDI80423.1 - 5.8 7.0 16.1 83 3.3 16.1 2.2 1 1 0 1 1 1 0 DivIVA protein DUF4200 PF13863.6 CDI80423.1 - 5.9 7.3 20.5 10 6.6 13.4 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) PCRF PF03462.18 CDI80423.1 - 7.7 6.3 11.1 15 5.4 10.4 1.7 1 1 1 2 2 2 0 PCRF domain Fib_alpha PF08702.10 CDI80423.1 - 9.4 6.4 11.0 16 5.7 0.6 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 CDI80423.1 - 9.6 5.4 17.5 8.5 5.6 2.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) RskA PF10099.9 CDI80465.1 - 0.0051 17.1 24.6 0.058 13.7 8.1 2.7 1 1 1 2 2 2 2 Anti-sigma-K factor rskA Adeno_PIX PF03955.14 CDI80465.1 - 0.11 12.7 2.3 7.9 6.7 0.4 2.2 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) Synuclein PF01387.17 CDI80465.1 - 0.34 11.1 6.2 0.1 12.8 1.6 2.2 1 1 1 2 2 2 0 Synuclein TCP PF03634.13 CDI80465.1 - 0.46 11.0 20.9 0.17 12.4 13.3 2.3 2 0 0 2 2 2 0 TCP family transcription factor Pinin_SDK_memA PF04696.13 CDI80465.1 - 6.1 6.9 41.4 0.55 10.3 28.1 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region SR-25 PF10500.9 CDI80470.1 - 0.48 10.0 35.3 98 2.4 35.3 2.1 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein SMYLE_N PF18615.1 CDI80470.1 - 1.5 8.3 19.5 2.1 7.8 19.5 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain AAA_23 PF13476.6 CDI80470.1 - 2 8.9 26.5 2.6 8.5 26.5 1.1 1 0 0 1 1 1 0 AAA domain Caldesmon PF02029.15 CDI80470.1 - 3.2 6.4 32.7 4.1 6.0 32.7 1.0 1 0 0 1 1 1 0 Caldesmon TipE PF16972.5 CDI80470.1 - 9.8 5.2 8.3 10 5.2 8.3 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE Tub_N PF16322.5 CDI80475.1 - 0.019 15.4 22.6 0.019 15.4 22.6 1.9 2 0 0 2 2 2 0 Tubby N-terminal Spt20 PF12090.8 CDI80475.1 - 0.3 10.7 41.7 0.02 14.5 36.6 1.7 2 0 0 2 2 2 0 Spt20 family Otopetrin PF03189.13 CDI80475.1 - 1.6 7.4 4.3 1.6 7.4 4.3 1.3 1 0 0 1 1 1 0 Otopetrin eIF-3_zeta PF05091.12 CDI80475.1 - 2.4 7.0 22.5 3.2 6.6 22.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Beach PF02138.18 CDI80481.1 - 1.6e-31 109.7 0.0 5.8e-28 98.0 0.0 2.5 2 0 0 2 2 2 2 Beige/BEACH domain Spt20 PF12090.8 CDI80481.1 - 0.00054 19.7 7.8 0.00054 19.7 7.8 3.3 3 0 0 3 3 3 2 Spt20 family FIST_C PF10442.9 CDI80481.1 - 0.83 9.6 6.1 13 5.8 0.1 3.0 1 1 1 2 2 2 0 FIST C domain SR-25 PF10500.9 CDI80481.1 - 3 7.4 37.7 2.9 7.4 11.8 3.2 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 CDI80494.1 - 2.4e-71 240.2 0.0 3.6e-71 239.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80494.1 - 2.3e-36 125.4 0.0 3.8e-36 124.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDI80494.1 - 3.8e-06 27.0 3.7 6.4e-05 23.0 0.1 3.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CDI80494.1 - 0.00021 20.7 0.0 0.00063 19.1 0.0 1.7 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 CDI80494.1 - 0.00073 18.9 0.3 0.0015 17.9 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDI80494.1 - 0.0026 16.8 0.2 0.0055 15.7 0.2 1.5 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 CDI80494.1 - 0.091 12.4 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 CDI80494.1 - 0.11 12.0 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase YchF-GTPase_C PF06071.13 CDI80495.1 - 3e-05 24.1 2.9 4.1e-05 23.7 0.0 2.5 2 1 0 3 3 3 1 Protein of unknown function (DUF933) Polyhedrin PF00738.18 CDI80495.1 - 0.11 11.8 1.0 0.17 11.2 1.0 1.2 1 0 0 1 1 1 0 Polyhedrin ORC4_C PF14629.6 CDI80496.1 - 0.018 14.4 0.0 0.039 13.3 0.0 1.7 1 1 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus SUIM_assoc PF16619.5 CDI80496.1 - 0.11 12.5 0.3 0.11 12.5 0.3 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 ORC_WH_C PF18137.1 CDI80496.1 - 0.86 9.7 6.6 0.79 9.8 1.9 2.4 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal BAT2_N PF07001.11 CDI80496.1 - 1.1 9.7 16.5 0.063 13.7 5.1 2.4 2 0 0 2 2 2 0 BAT2 N-terminus Spt20 PF12090.8 CDI80496.1 - 2.3 7.8 14.4 2.3 7.8 3.1 2.2 2 0 0 2 2 2 0 Spt20 family Activator_LAG-3 PF11498.8 CDI80496.1 - 4.1 6.3 17.5 1.7 7.5 9.7 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 NESP55 PF06390.12 CDI80503.1 - 6.1e-05 22.8 30.3 6.1e-05 22.8 30.3 4.1 1 1 4 5 5 5 2 Neuroendocrine-specific golgi protein P55 (NESP55) Trypan_PARP PF05887.11 CDI80503.1 - 0.00058 19.9 21.8 0.00058 19.9 21.8 2.3 1 1 1 2 2 2 1 Procyclic acidic repetitive protein (PARP) SDA1 PF05285.12 CDI80503.1 - 0.37 10.2 62.9 0.052 13.0 19.7 2.3 2 0 0 2 2 2 0 SDA1 DUF572 PF04502.13 CDI80521.1 - 0.0015 18.2 14.1 0.0022 17.7 14.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF2722 PF10846.8 CDI80521.1 - 0.004 16.2 40.9 0.0042 16.1 17.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) RAB3GAP2_N PF14655.6 CDI80521.1 - 0.0057 16.0 7.2 0.0057 16.0 7.2 2.4 1 1 0 2 2 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Lin-8 PF03353.15 CDI80521.1 - 0.081 12.5 20.7 0.13 11.8 20.7 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Hamartin PF04388.12 CDI80521.1 - 0.11 11.1 18.9 0.16 10.6 18.9 1.3 1 0 0 1 1 1 0 Hamartin protein LMBR1 PF04791.16 CDI80521.1 - 0.17 10.8 4.7 0.2 10.6 4.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein SLC12 PF03522.15 CDI80521.1 - 0.18 10.8 14.1 0.23 10.4 14.1 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Eapp_C PF10238.9 CDI80521.1 - 0.22 11.6 14.7 0.64 10.1 5.9 2.6 2 0 0 2 2 2 0 E2F-associated phosphoprotein Macoilin PF09726.9 CDI80521.1 - 0.25 9.9 17.0 0.61 8.6 17.0 1.7 1 0 0 1 1 1 0 Macoilin family SAGA-Tad1 PF12767.7 CDI80521.1 - 0.47 10.1 15.3 0.76 9.5 15.3 1.4 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit GET2 PF08690.10 CDI80521.1 - 0.54 9.9 21.5 1.3 8.6 21.5 1.6 1 0 0 1 1 1 0 GET complex subunit GET2 MAT1 PF06391.13 CDI80521.1 - 0.88 9.4 24.6 1.6 8.5 24.6 1.3 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Hid1 PF12722.7 CDI80521.1 - 1.4 7.0 17.0 1.8 6.6 17.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ALMT PF11744.8 CDI80521.1 - 1.5 7.5 11.9 2.1 7.1 11.9 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter GREB1 PF15782.5 CDI80521.1 - 2.2 5.3 21.0 2.8 5.0 21.0 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PIP5K PF01504.18 CDI80521.1 - 3.5 6.8 15.0 2 7.6 13.0 1.5 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase RNA_pol_Rbc25 PF08292.12 CDI80521.1 - 3.9 7.7 14.4 1.7 8.9 5.0 2.4 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 DivIC PF04977.15 CDI80521.1 - 5.6 6.8 32.7 1.4 8.7 6.1 2.4 2 0 0 2 2 2 0 Septum formation initiator DUF4746 PF15928.5 CDI80521.1 - 5.9 6.2 11.9 12 5.2 11.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MDM10 PF12519.8 CDI80521.1 - 6.9 5.4 14.5 10 4.8 14.5 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SelP_N PF04592.14 CDI80526.1 - 4 6.8 35.5 4.7 6.5 35.5 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Trp_oprn_chp PF09534.10 CDI80539.1 - 0.0039 17.0 8.6 0.005 16.7 8.6 1.1 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Suf PF05843.14 CDI80539.1 - 0.007 16.4 9.0 0.007 16.4 9.0 1.0 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) DUF4834 PF16118.5 CDI80539.1 - 0.0073 17.2 6.1 0.0085 17.0 6.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) TERB2 PF15101.6 CDI80539.1 - 0.0075 16.3 8.4 0.0075 16.3 8.4 1.1 1 0 0 1 1 1 1 Telomere-associated protein TERB2 Topoisom_I_N PF02919.15 CDI80539.1 - 0.0083 15.6 1.2 0.0092 15.5 1.2 1.1 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Spt20 PF12090.8 CDI80539.1 - 0.0099 15.5 26.9 0.011 15.4 26.9 1.1 1 0 0 1 1 1 1 Spt20 family DUF3357 PF11837.8 CDI80539.1 - 0.014 15.9 1.8 0.018 15.5 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Glt_symporter PF03616.14 CDI80539.1 - 0.02 13.6 2.1 0.023 13.4 2.1 1.0 1 0 0 1 1 1 0 Sodium/glutamate symporter ATG2_CAD PF13329.6 CDI80539.1 - 0.021 14.5 4.3 0.03 14.0 4.3 1.1 1 0 0 1 1 1 0 Autophagy-related protein 2 CAD motif Tim54 PF11711.8 CDI80539.1 - 0.031 13.1 3.0 0.032 13.0 3.0 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ctr PF04145.15 CDI80539.1 - 0.032 14.8 2.2 0.037 14.7 2.2 1.0 1 0 0 1 1 1 0 Ctr copper transporter family FHIPEP PF00771.20 CDI80539.1 - 0.035 12.6 5.2 0.036 12.5 5.2 1.0 1 0 0 1 1 1 0 FHIPEP family MTP18 PF10558.9 CDI80539.1 - 0.044 13.8 2.5 0.048 13.6 2.5 1.1 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) DUF2232 PF09991.9 CDI80539.1 - 0.045 12.9 1.7 0.053 12.7 1.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Peroxin-13_N PF04088.13 CDI80539.1 - 0.059 13.7 0.9 0.06 13.6 0.9 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region TMEM65 PF10507.9 CDI80539.1 - 0.061 13.3 3.7 0.082 12.9 3.7 1.2 1 0 0 1 1 1 0 Transmembrane protein 65 Presenilin PF01080.17 CDI80539.1 - 0.062 12.1 5.7 0.069 11.9 5.7 1.2 1 0 0 1 1 1 0 Presenilin Orf78 PF06024.12 CDI80539.1 - 0.071 13.4 2.2 0.077 13.3 2.2 1.2 1 0 0 1 1 1 0 Orf78 (ac78) RskA PF10099.9 CDI80539.1 - 0.096 13.0 24.9 0.16 12.2 24.9 1.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA TMEM51 PF15345.6 CDI80539.1 - 0.11 12.3 7.0 0.11 12.3 7.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 eIF-3_zeta PF05091.12 CDI80539.1 - 0.11 11.4 9.9 0.11 11.5 9.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) UPF0560 PF10577.9 CDI80539.1 - 0.11 10.9 12.7 0.11 11.0 12.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 BAF1_ABF1 PF04684.13 CDI80539.1 - 0.11 11.5 8.8 0.13 11.3 8.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF719 PF05334.13 CDI80539.1 - 0.12 12.6 6.5 0.14 12.4 6.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF719) CPSF100_C PF13299.6 CDI80539.1 - 0.12 12.6 5.5 0.13 12.5 5.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal EIF4E-T PF10477.9 CDI80539.1 - 0.12 11.2 11.2 0.1 11.4 11.2 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Peptidase_S15 PF02129.18 CDI80539.1 - 0.12 11.9 7.5 0.13 11.8 7.5 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Connexin PF00029.19 CDI80539.1 - 0.12 12.1 3.2 0.13 12.0 3.2 1.1 1 0 0 1 1 1 0 Connexin EIIBC-GUT_N PF03612.14 CDI80539.1 - 0.13 12.0 5.4 0.14 11.9 5.4 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus EOS1 PF12326.8 CDI80539.1 - 0.15 12.0 1.4 0.16 11.9 1.4 1.1 1 0 0 1 1 1 0 N-glycosylation protein Roughex PF06020.11 CDI80539.1 - 0.16 11.1 9.3 0.16 11.0 9.3 1.1 1 0 0 1 1 1 0 Drosophila roughex protein FAM176 PF14851.6 CDI80539.1 - 0.16 11.6 1.9 0.18 11.5 1.9 1.1 1 0 0 1 1 1 0 FAM176 family AIF_C PF14721.6 CDI80539.1 - 0.18 12.2 5.0 0.21 11.9 5.0 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term 2HCT PF03390.15 CDI80539.1 - 0.18 10.4 2.8 0.21 10.2 2.8 1.0 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family R_equi_Vir PF05526.11 CDI80539.1 - 0.18 11.6 9.2 0.21 11.4 9.2 1.0 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Coilin_N PF15862.5 CDI80539.1 - 0.21 11.4 8.9 0.24 11.2 8.9 1.1 1 0 0 1 1 1 0 Coilin N-terminus RNA_pol_Rbc25 PF08292.12 CDI80539.1 - 0.21 11.8 4.7 0.24 11.6 4.7 1.2 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 DUF3767 PF12597.8 CDI80539.1 - 0.22 11.4 8.3 0.29 11.0 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) SID-1_RNA_chan PF13965.6 CDI80539.1 - 0.22 9.9 0.8 0.24 9.8 0.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI80539.1 - 0.24 9.3 5.0 0.23 9.3 5.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5349 PF17298.2 CDI80539.1 - 0.26 11.0 12.1 0.27 11.0 12.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5349) PvlArgDC PF01862.16 CDI80539.1 - 0.26 11.1 4.4 0.38 10.5 4.4 1.2 1 0 0 1 1 1 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) TFIIA PF03153.13 CDI80539.1 - 0.28 11.1 29.2 0.3 11.0 29.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit OATP PF03137.20 CDI80539.1 - 0.3 9.3 1.7 0.31 9.3 1.7 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DDHD PF02862.17 CDI80539.1 - 0.31 11.2 6.2 0.32 11.1 6.2 1.1 1 0 0 1 1 1 0 DDHD domain DUF775 PF05603.12 CDI80539.1 - 0.32 10.5 9.3 0.33 10.5 9.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Med15 PF09606.10 CDI80539.1 - 0.34 9.5 25.7 0.32 9.6 25.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Band_3_cyto PF07565.13 CDI80539.1 - 0.34 10.7 5.8 0.35 10.6 5.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF1980 PF09323.10 CDI80539.1 - 0.38 10.7 3.6 0.43 10.5 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Neur_chan_memb PF02932.16 CDI80539.1 - 0.39 10.7 4.1 0.39 10.7 4.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Serinc PF03348.15 CDI80539.1 - 0.43 9.4 3.2 0.46 9.3 3.2 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2722 PF10846.8 CDI80539.1 - 0.48 9.3 26.0 0.58 9.0 26.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Renin_r PF07850.14 CDI80539.1 - 0.49 11.0 2.1 0.58 10.8 2.1 1.2 1 0 0 1 1 1 0 Renin receptor-like protein CLN3 PF02487.17 CDI80539.1 - 0.5 9.4 2.9 0.51 9.3 2.9 1.1 1 0 0 1 1 1 0 CLN3 protein PigN PF04987.14 CDI80539.1 - 0.64 8.8 2.0 0.64 8.8 2.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) HemX PF04375.14 CDI80539.1 - 1.1 8.5 22.1 1.2 8.4 22.1 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase PAT1 PF09770.9 CDI80539.1 - 1.1 7.5 16.4 1.1 7.4 16.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SprA-related PF12118.8 CDI80539.1 - 1.5 7.9 23.2 1.8 7.6 23.2 1.1 1 0 0 1 1 1 0 SprA-related family DUF3537 PF12056.8 CDI80539.1 - 1.5 7.6 7.8 1.7 7.4 7.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) Kei1 PF08552.11 CDI80539.1 - 2 8.3 8.8 2.4 8.0 8.8 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 TMEM208_SND2 PF05620.11 CDI80539.1 - 2.4 7.9 6.5 2.6 7.8 6.5 1.3 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 SRRM_C PF15230.6 CDI80539.1 - 3.7 8.2 6.1 5.3 7.7 6.1 1.2 1 0 0 1 1 1 0 Serine/arginine repetitive matrix protein C-terminus FAM199X PF15814.5 CDI80539.1 - 4.5 6.2 8.4 5.4 6.0 8.4 1.0 1 0 0 1 1 1 0 Protein family FAM199X Ribosomal_60s PF00428.19 CDI80541.1 - 3.3 8.4 10.2 9 7.0 10.2 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein SR-25 PF10500.9 CDI80543.1 - 0.0093 15.6 17.1 0.011 15.4 17.1 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein PNISR PF15996.5 CDI80543.1 - 0.31 11.3 21.1 0.39 11.0 21.1 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Macoilin PF09726.9 CDI80543.1 - 0.43 9.1 18.1 0.53 8.8 18.1 1.1 1 0 0 1 1 1 0 Macoilin family CCDC84 PF14968.6 CDI80543.1 - 0.94 9.0 20.6 1.1 8.9 20.6 1.0 1 0 0 1 1 1 0 Coiled coil protein 84 SLC12 PF03522.15 CDI80543.1 - 2.3 7.2 19.2 2.4 7.1 19.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Apt1 PF10351.9 CDI80543.1 - 2.3 7.0 14.2 2.5 6.9 14.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain LCD1 PF09798.9 CDI80543.1 - 2.7 6.4 11.6 3 6.3 11.6 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Mem_trans PF03547.18 CDI80543.1 - 3.4 6.0 5.7 3.4 6.0 5.7 1.2 1 0 0 1 1 1 0 Membrane transport protein Presenilin PF01080.17 CDI80543.1 - 3.8 6.2 21.6 4.6 5.9 21.6 1.2 1 0 0 1 1 1 0 Presenilin VIT1 PF01988.19 CDI80543.1 - 4 7.3 11.1 5.7 6.7 11.1 1.2 1 0 0 1 1 1 0 VIT family CAML PF14963.6 CDI80543.1 - 4.3 7.4 10.2 5.1 7.1 10.2 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Peptidase_S64 PF08192.11 CDI80543.1 - 4.7 5.6 20.3 5.2 5.4 20.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 Sporozoite_P67 PF05642.11 CDI80543.1 - 5.3 5.0 17.7 6.4 4.7 17.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen V_ATPase_I PF01496.19 CDI80543.1 - 7.2 4.4 15.2 8.1 4.2 15.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Miga PF10265.9 CDI80543.1 - 7.6 5.4 16.8 9 5.1 16.8 1.1 1 0 0 1 1 1 0 Mitoguardin BAF1_ABF1 PF04684.13 CDI80543.1 - 8.1 5.4 22.9 9.8 5.1 22.9 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor ALMT PF11744.8 CDI80543.1 - 9.1 5.0 15.4 9.6 4.9 15.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FtsJ PF01728.19 CDI80551.1 - 1.1e-23 84.2 0.2 1.7e-22 80.4 0.1 2.3 1 1 0 1 1 1 1 FtsJ-like methyltransferase Presenilin PF01080.17 CDI80551.1 - 0.0017 17.2 13.4 0.0017 17.2 13.4 3.1 2 1 1 3 3 2 1 Presenilin SID-1_RNA_chan PF13965.6 CDI80551.1 - 0.0023 16.5 8.5 0.0023 16.5 8.5 2.9 2 1 0 3 3 2 1 dsRNA-gated channel SID-1 Connexin PF00029.19 CDI80551.1 - 0.0035 17.1 7.6 0.0035 17.1 7.6 3.6 2 1 1 3 3 1 1 Connexin DUF4834 PF16118.5 CDI80551.1 - 0.0042 18.0 13.7 0.0042 18.0 13.7 4.9 3 2 2 5 5 4 1 Domain of unknown function (DUF4834) DUF572 PF04502.13 CDI80551.1 - 0.0086 15.7 10.4 0.0086 15.7 10.4 3.0 2 1 0 2 2 1 1 Family of unknown function (DUF572) Ni_hydr_CYTB PF01292.20 CDI80551.1 - 0.011 15.3 0.3 0.11 12.1 0.0 2.0 2 0 0 2 2 2 0 Prokaryotic cytochrome b561 Tmemb_9 PF05434.11 CDI80551.1 - 0.011 15.6 7.8 0.011 15.6 7.8 4.1 3 1 0 3 3 2 0 TMEM9 OAD_gamma PF04277.13 CDI80551.1 - 0.046 14.3 0.2 0.046 14.3 0.2 5.6 4 2 0 4 4 2 0 Oxaloacetate decarboxylase, gamma chain CRA PF06589.11 CDI80551.1 - 0.08 13.1 0.6 0.08 13.1 0.6 3.6 3 1 0 3 3 2 0 Circumsporozoite-related antigen (CRA) DUF2052 PF09747.9 CDI80551.1 - 0.88 9.7 49.5 0.5 10.5 1.4 3.9 4 0 0 4 4 4 0 Coiled-coil domain containing protein (DUF2052) DUF1467 PF07330.12 CDI80551.1 - 1.5 8.8 6.6 6.5 6.8 4.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1467) BSMAP PF12280.8 CDI80551.1 - 1.8 8.7 0.0 1.8 8.7 0.0 4.6 2 2 2 4 4 2 0 Brain specific membrane anchored protein MAPEG PF01124.18 CDI80551.1 - 2.7 7.9 10.0 0.62 10.0 0.8 2.6 2 0 0 2 2 2 0 MAPEG family NicO PF03824.16 CDI80551.1 - 4.4 6.6 10.0 0.5 9.7 4.8 1.9 2 0 0 2 2 2 0 High-affinity nickel-transport protein FAM60A PF15396.6 CDI80551.1 - 4.5 7.2 47.0 1.9 8.4 10.4 3.3 3 0 0 3 3 3 0 Protein Family FAM60A Dpy19 PF10034.9 CDI80551.1 - 5.3 5.1 14.6 1.6 6.8 9.2 2.3 2 0 0 2 2 2 0 Q-cell neuroblast polarisation Cytochrom_B_N_2 PF13631.6 CDI80551.1 - 8.7 6.3 8.1 35 4.4 4.1 2.4 2 1 0 2 2 2 0 Cytochrome b(N-terminal)/b6/petB MCU PF04678.13 CDI80557.1 - 0.031 14.4 5.2 0.039 14.1 5.2 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Macoilin PF09726.9 CDI80557.1 - 0.22 10.1 6.5 0.25 9.9 6.5 1.1 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI80557.1 - 2.6 7.9 21.3 3.1 7.7 21.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Endomucin PF07010.12 CDI80557.1 - 3.3 7.6 15.3 4 7.4 15.3 1.1 1 0 0 1 1 1 0 Endomucin GREB1 PF15782.5 CDI80557.1 - 4.2 4.4 11.8 4.6 4.2 11.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Spt20 PF12090.8 CDI80557.1 - 9.5 5.7 10.8 11 5.5 10.8 1.1 1 0 0 1 1 1 0 Spt20 family Trp_oprn_chp PF09534.10 CDI80558.1 - 0.00064 19.6 22.1 0.0008 19.3 22.1 1.1 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Spt20 PF12090.8 CDI80558.1 - 0.0012 18.5 20.2 0.0012 18.5 20.2 1.2 1 0 0 1 1 1 1 Spt20 family DUF2232 PF09991.9 CDI80558.1 - 0.038 13.2 3.1 0.047 12.9 3.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Med3 PF11593.8 CDI80558.1 - 0.06 12.5 42.8 0.077 12.2 42.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal MarC PF01914.17 CDI80558.1 - 0.11 11.8 0.2 0.11 11.8 0.2 1.5 1 1 1 2 2 2 0 MarC family integral membrane protein DUF2207 PF09972.9 CDI80558.1 - 0.14 10.9 0.2 0.14 10.8 0.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) tRNA_lig_CPD PF08302.11 CDI80558.1 - 0.14 11.6 8.5 0.16 11.4 8.3 1.3 1 1 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain SARAF PF06682.12 CDI80558.1 - 0.15 11.7 12.5 0.17 11.5 12.5 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Porph_ging PF09697.10 CDI80558.1 - 0.24 11.9 6.9 0.079 13.5 3.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (Porph_ging) EphA2_TM PF14575.6 CDI80558.1 - 0.25 12.2 1.9 0.5 11.3 0.9 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Lin-8 PF03353.15 CDI80558.1 - 0.59 9.6 10.8 0.59 9.7 10.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TFIIA PF03153.13 CDI80558.1 - 1.2 9.1 33.6 1.3 9.0 33.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4366 PF14283.6 CDI80558.1 - 1.6 8.8 9.9 2 8.5 9.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) FHIPEP PF00771.20 CDI80558.1 - 3.3 6.1 12.4 3.2 6.1 11.7 1.2 1 1 0 1 1 1 0 FHIPEP family Dicty_REP PF05086.12 CDI80558.1 - 5.9 4.7 10.1 6 4.7 10.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AAA_23 PF13476.6 CDI80569.1 - 0.14 12.7 26.3 0.23 11.9 26.3 1.4 1 0 0 1 1 1 0 AAA domain DUF3023 PF11224.8 CDI80569.1 - 0.33 10.8 3.2 0.64 9.9 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3023) AF-4 PF05110.13 CDI80569.1 - 2.7 6.0 51.5 4.4 5.3 51.5 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Ribosomal_60s PF00428.19 CDI80569.1 - 4.8 7.8 17.5 1.7 9.3 12.8 2.5 3 0 0 3 3 3 0 60s Acidic ribosomal protein Actin PF00022.19 CDI80591.1 - 3.4e-29 101.7 22.6 1.1e-17 63.8 12.5 3.3 2 1 1 3 3 3 2 Actin RskA PF10099.9 CDI80591.1 - 2.5e-05 24.7 1.3 2.5e-05 24.7 1.3 5.4 2 2 1 3 3 2 1 Anti-sigma-K factor rskA DUF4175 PF13779.6 CDI80591.1 - 0.0015 16.5 18.4 0.0015 16.5 18.4 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4175) SUIM_assoc PF16619.5 CDI80591.1 - 0.0016 18.5 0.0 0.0016 18.5 0.0 9.9 5 3 2 7 7 4 2 Unstructured region C-term to UIM in Ataxin3 CNDH2_C PF16858.5 CDI80591.1 - 0.0016 18.4 25.7 0.038 13.9 7.0 3.2 3 0 0 3 3 3 2 Condensin II complex subunit CAP-H2 or CNDH2, C-term Connexin PF00029.19 CDI80591.1 - 0.061 13.1 22.9 0.16 11.7 5.9 3.3 3 0 0 3 3 3 0 Connexin SelP_N PF04592.14 CDI80591.1 - 0.92 8.9 60.4 0.02 14.3 28.5 3.7 3 0 0 3 3 3 0 Selenoprotein P, N terminal region Exonuc_VII_L PF02601.15 CDI80591.1 - 1.2 8.6 42.4 2.6 7.5 10.9 3.1 3 0 0 3 3 3 0 Exonuclease VII, large subunit DUF4179 PF13786.6 CDI80591.1 - 1.5 9.4 12.7 4.1 7.9 0.0 4.2 3 2 0 3 3 3 0 Domain of unknown function (DUF4179) RPOL_N PF14700.6 CDI80591.1 - 7 5.9 35.2 0.89 8.9 8.1 3.4 3 0 0 3 3 3 0 DNA-directed RNA polymerase N-terminal MFS_2 PF13347.6 CDI80591.1 - 7.4 5.0 6.0 19 3.7 0.7 2.3 2 0 0 2 2 2 0 MFS/sugar transport protein DUF2052 PF09747.9 CDI80591.1 - 7.5 6.6 33.9 0.49 10.5 3.7 3.4 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) TT_ORF1 PF02956.14 CDI80629.1 - 1.9 7.1 23.9 3.3 6.3 23.9 1.4 1 0 0 1 1 1 0 TT viral orf 1 DUF2722 PF10846.8 CDI80654.1 - 0.00021 20.4 22.4 0.00039 19.5 7.7 9.0 7 1 1 8 8 8 3 Protein of unknown function (DUF2722) DUF755 PF05501.11 CDI80654.1 - 0.015 15.5 16.3 0.015 15.5 16.3 9.0 8 1 0 8 8 8 0 Domain of unknown function (DUF755) DUF3915 PF13054.6 CDI80654.1 - 6.7 6.7 0.0 6.7 6.7 0.0 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF3915) Coilin_N PF15862.5 CDI80660.1 - 0.67 9.8 11.4 1.3 8.8 11.4 1.5 1 0 0 1 1 1 0 Coilin N-terminus PAT1 PF09770.9 CDI80660.1 - 1.5 7.0 31.1 1.8 6.8 31.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AAA_23 PF13476.6 CDI80660.1 - 1.9 9.0 13.8 2.4 8.6 13.8 1.1 1 0 0 1 1 1 0 AAA domain DUF45 PF01863.17 CDI80660.1 - 2.7 8.0 11.0 4.1 7.4 11.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF45 PAP1 PF08601.10 CDI80678.1 - 3.2e-05 23.9 3.7 3.2e-05 23.9 3.7 8.1 4 3 4 9 9 9 2 Transcription factor PAP1 SPX PF03105.19 CDI80678.1 - 0.0048 16.9 34.9 0.0048 16.9 34.9 6.2 5 2 1 6 6 6 2 SPX domain Pkinase PF00069.25 CDI80681.1 - 3.3e-05 23.4 5.7 0.00085 18.8 2.5 3.0 2 1 0 2 2 2 1 Protein kinase domain Spt20 PF12090.8 CDI80681.1 - 0.0078 15.9 6.7 0.0078 15.9 6.7 3.0 3 0 0 3 3 3 2 Spt20 family SUIM_assoc PF16619.5 CDI80681.1 - 0.013 15.5 7.1 0.013 15.5 7.1 3.2 3 0 0 3 3 2 0 Unstructured region C-term to UIM in Ataxin3 V_ATPase_I PF01496.19 CDI80681.1 - 0.016 13.1 6.1 0.02 12.9 6.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIC PF04977.15 CDI80681.1 - 0.083 12.7 23.2 0.55 10.0 7.9 2.3 2 0 0 2 2 2 0 Septum formation initiator MAT1 PF06391.13 CDI80681.1 - 0.27 11.0 23.0 0.035 13.9 18.9 1.5 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 FSA_C PF10479.9 CDI80681.1 - 3.1 5.8 22.9 7.9 4.5 22.9 1.7 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SID-1_RNA_chan PF13965.6 CDI80681.1 - 3.3 6.0 5.5 4.2 5.7 5.5 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4810 PF16068.5 CDI80681.1 - 3.8 8.1 12.5 4.6 7.9 1.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4810) ORC_WH_C PF18137.1 CDI80681.1 - 6.1 6.9 11.6 0.68 10.0 6.8 1.8 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal RR_TM4-6 PF06459.12 CDI80681.1 - 7.4 6.3 14.0 3.2 7.5 10.2 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RLL PF10036.9 CDI80684.1 - 7.6e-27 94.8 9.4 8.3e-27 94.6 9.4 1.0 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein Spt20 PF12090.8 CDI80684.1 - 0.03 13.9 20.9 0.25 10.9 11.8 2.1 2 0 0 2 2 2 0 Spt20 family Presenilin PF01080.17 CDI80684.1 - 0.18 10.5 1.2 0.22 10.2 1.2 1.1 1 0 0 1 1 1 0 Presenilin WASH-7_C PF14746.6 CDI80684.1 - 0.53 10.0 4.9 1.3 8.7 2.1 2.2 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal DUF4834 PF16118.5 CDI80684.1 - 1.1 10.3 5.7 0.49 11.4 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Rpp20 PF12328.8 CDI80684.1 - 1.4 8.9 5.4 1.2 9.1 1.0 2.1 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P ANAPC_CDC26 PF10471.9 CDI80684.1 - 3.1 8.7 24.1 0.076 13.9 7.5 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 Rxt3 PF08642.10 CDI80684.1 - 3.2 8.5 4.7 44 4.9 4.7 2.1 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 K_channel_TID PF07941.11 CDI80684.1 - 4.4 7.8 10.0 2.9 8.4 2.1 2.5 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain DNA_ligase_aden PF01653.18 CDI80691.1 - 2.6e-05 23.4 0.2 2.6e-05 23.4 0.2 1.9 2 1 0 2 2 2 1 NAD-dependent DNA ligase adenylation domain RskA PF10099.9 CDI80691.1 - 0.0001 22.7 6.4 0.0001 22.7 6.4 3.7 2 2 1 3 3 2 1 Anti-sigma-K factor rskA RAB3GAP2_N PF14655.6 CDI80691.1 - 0.0057 16.0 2.5 0.0057 16.0 2.5 2.7 3 0 0 3 3 3 1 Rab3 GTPase-activating protein regulatory subunit N-terminus ARF7EP_C PF14949.6 CDI80691.1 - 0.0078 16.8 0.9 0.0078 16.8 0.9 3.2 3 1 0 4 4 2 1 ARF7 effector protein C-terminus DUF4834 PF16118.5 CDI80691.1 - 0.051 14.5 2.6 0.051 14.5 2.6 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4834) DUF4207 PF13904.6 CDI80691.1 - 0.36 10.5 41.0 0.13 11.9 5.5 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4207) TFB6 PF17110.5 CDI80691.1 - 0.39 10.5 6.0 6.9 6.4 2.3 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Roughex PF06020.11 CDI80691.1 - 0.39 9.8 19.4 0.26 10.3 3.9 2.5 2 0 0 2 2 2 0 Drosophila roughex protein Pinin_SDK_memA PF04696.13 CDI80691.1 - 0.47 10.5 30.7 0.045 13.8 10.8 2.3 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Presenilin PF01080.17 CDI80691.1 - 1.4 7.6 30.8 0.35 9.6 9.3 2.3 2 0 0 2 2 2 0 Presenilin eIF-3_zeta PF05091.12 CDI80691.1 - 2 7.3 20.1 0.52 9.2 3.2 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) OmpH PF03938.14 CDI80691.1 - 2.7 8.3 31.6 0.088 13.1 6.7 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) MecA PF05389.12 CDI80691.1 - 2.7 7.6 17.3 1.1 8.9 2.5 2.6 2 1 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF2681 PF10883.8 CDI80691.1 - 3.5 8.1 29.5 0.65 10.4 8.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) AAA_23 PF13476.6 CDI80691.1 - 6.3 7.2 15.8 3 8.3 2.7 2.3 2 0 0 2 2 2 0 AAA domain Spore_coat_CotO PF14153.6 CDI80691.1 - 9.6 6.1 24.0 4.4 7.2 7.0 2.4 2 0 0 2 2 2 0 Spore coat protein CotO DUF4207 PF13904.6 CDI80692.1 - 2e-05 24.5 29.9 2e-05 24.5 29.9 3.2 1 1 2 3 3 3 1 Domain of unknown function (DUF4207) RskA PF10099.9 CDI80692.1 - 0.17 12.2 89.2 0.097 13.0 10.7 4.8 1 1 2 4 4 4 0 Anti-sigma-K factor rskA FAM176 PF14851.6 CDI80698.1 - 0.0073 16.0 7.4 0.024 14.3 1.1 2.2 2 0 0 2 2 2 1 FAM176 family NST1 PF13945.6 CDI80698.1 - 0.0095 16.1 15.9 0.0095 16.1 15.9 2.1 2 0 0 2 2 1 1 Salt tolerance down-regulator RskA PF10099.9 CDI80698.1 - 0.028 14.7 49.3 0.76 10.0 10.4 2.3 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF4366 PF14283.6 CDI80698.1 - 0.11 12.5 16.1 0.03 14.4 5.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) Afi1 PF07792.12 CDI80698.1 - 0.15 12.6 14.0 0.38 11.2 3.7 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking EphA2_TM PF14575.6 CDI80698.1 - 0.37 11.7 19.8 4.5 8.2 1.9 3.0 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain GRP PF07172.11 CDI80698.1 - 0.39 11.4 8.4 0.16 12.6 2.3 2.3 2 1 0 2 2 2 0 Glycine rich protein family DUF1772 PF08592.11 CDI80698.1 - 0.39 11.0 16.5 0.98 9.7 16.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) DUF2149 PF09919.9 CDI80698.1 - 0.54 10.5 10.4 0.16 12.2 2.3 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2149) TMEM144 PF07857.12 CDI80698.1 - 0.56 9.1 2.7 0.27 10.2 0.2 1.7 2 0 0 2 2 2 0 Transmembrane family, TMEM144 of transporters Ndc1_Nup PF09531.10 CDI80698.1 - 1.1 7.9 24.5 1.4 7.5 24.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Otopetrin PF03189.13 CDI80698.1 - 1.2 7.8 10.0 1.9 7.2 10.0 1.2 1 0 0 1 1 1 0 Otopetrin Trp_oprn_chp PF09534.10 CDI80698.1 - 1.4 8.7 35.7 6 6.6 25.4 2.8 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4666 PF15697.5 CDI80698.1 - 1.8 9.3 18.4 0.23 12.1 6.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4666) DUF3402 PF11882.8 CDI80698.1 - 1.8 7.6 19.3 0.16 11.1 7.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3402) YjeJ PF15922.5 CDI80698.1 - 2.2 7.4 15.1 0.17 11.1 3.3 2.2 2 0 0 2 2 2 0 YjeJ-like Miga PF10265.9 CDI80698.1 - 2.3 7.1 25.6 9.9 5.0 25.6 1.7 1 1 0 1 1 1 0 Mitoguardin DUF4834 PF16118.5 CDI80698.1 - 2.5 9.1 33.8 1.2 10.2 5.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Pinin_SDK_memA PF04696.13 CDI80698.1 - 2.6 8.1 39.8 0.31 11.1 16.8 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region O-antigen_lig PF13425.6 CDI80698.1 - 3 6.5 9.3 46 2.6 9.4 1.9 1 1 0 1 1 1 0 O-antigen ligase like membrane protein Pet20 PF08692.10 CDI80698.1 - 4.1 8.1 10.3 9 7.0 3.0 2.2 2 0 0 2 2 2 0 Mitochondrial protein Pet20 BAF1_ABF1 PF04684.13 CDI80698.1 - 4.7 6.1 27.7 7.2 5.5 27.7 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor MPM1 PF17234.2 CDI80698.1 - 5.6 7.2 25.8 0.64 10.3 8.7 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF3169 PF11368.8 CDI80698.1 - 7.2 6.0 7.6 0.87 9.1 0.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3169) 7TM_GPCR_Sru PF10322.9 CDI80698.1 - 8.3 5.6 5.3 6.4 6.0 0.6 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sru DUF966 PF06136.13 CDI80698.1 - 8.9 5.9 22.5 12 5.5 22.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Caldesmon PF02029.15 CDI80699.1 - 0.00078 18.3 7.1 0.00078 18.3 7.1 2.4 2 1 0 2 2 2 1 Caldesmon DUF4079 PF13301.6 CDI80699.1 - 0.0043 17.2 0.0 0.0043 17.2 0.0 4.7 2 2 0 2 2 2 1 Protein of unknown function (DUF4079) DUF1772 PF08592.11 CDI80699.1 - 0.035 14.4 0.1 0.035 14.4 0.1 5.7 3 1 1 5 5 5 0 Domain of unknown function (DUF1772) DUF2339 PF10101.9 CDI80699.1 - 0.069 11.7 43.9 0.098 11.2 43.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) NFACT-R_1 PF05670.13 CDI80700.1 - 1.6e-26 93.1 1.7 1.1e-25 90.3 0.0 3.6 3 0 0 3 3 3 1 NFACT protein RNA binding domain RskA PF10099.9 CDI80700.1 - 1.6e-07 31.8 10.6 5e-06 26.9 5.0 15.0 3 2 9 13 13 13 8 Anti-sigma-K factor rskA EF-hand_1 PF00036.32 CDI80709.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_5 PF13202.6 CDI80709.1 - 0.15 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 CDI80709.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain eIF-3_zeta PF05091.12 CDI80713.1 - 0.12 11.3 22.3 0.12 11.3 22.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Pex14_N PF04695.13 CDI80713.1 - 0.27 11.9 25.5 0.29 11.8 25.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CobT PF06213.12 CDI80713.1 - 0.36 10.2 22.0 0.38 10.1 22.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Baculo_PP31 PF05311.11 CDI80713.1 - 0.76 9.2 13.2 0.8 9.1 13.2 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) SpoIIP PF07454.11 CDI80713.1 - 0.96 8.9 14.9 1 8.8 14.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4825 PF16107.5 CDI80713.1 - 1.1 9.4 9.0 1.7 8.8 9.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4825) Connexin PF00029.19 CDI80713.1 - 1.3 8.7 10.8 1.4 8.6 10.8 1.2 1 0 0 1 1 1 0 Connexin Senescence_reg PF04520.13 CDI80713.1 - 1.4 9.7 12.2 1.5 9.6 12.2 1.0 1 0 0 1 1 1 0 Senescence regulator OSTbeta PF15048.6 CDI80713.1 - 1.5 8.9 8.0 2.2 8.4 8.0 1.2 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein RR_TM4-6 PF06459.12 CDI80713.1 - 1.7 8.4 14.5 1.8 8.3 14.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 CDI80713.1 - 1.7 8.8 17.4 2 8.5 17.4 1.0 1 0 0 1 1 1 0 DDHD domain CPSF100_C PF13299.6 CDI80713.1 - 1.7 8.8 15.8 2.2 8.4 15.8 1.4 1 1 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 CDI80713.1 - 3.2 6.4 19.0 3.4 6.3 19.0 1.0 1 0 0 1 1 1 0 Presenilin Peptidase_S49_N PF08496.10 CDI80713.1 - 3.5 7.7 19.6 4.3 7.4 19.6 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF2126 PF09899.9 CDI80713.1 - 3.9 5.4 11.5 4.3 5.3 11.5 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Peptidase_U57 PF05582.12 CDI80713.1 - 3.9 6.7 11.2 4.1 6.6 11.2 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Rrn6 PF10214.9 CDI80713.1 - 4 5.8 22.1 4.1 5.8 22.1 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Tau95_N PF17682.1 CDI80713.1 - 4.2 7.6 11.3 7.3 6.8 11.3 1.5 1 1 0 1 1 1 0 Tau95 Triple barrel domain EOS1 PF12326.8 CDI80713.1 - 4.7 7.1 8.6 5.3 6.9 8.6 1.2 1 0 0 1 1 1 0 N-glycosylation protein SID-1_RNA_chan PF13965.6 CDI80713.1 - 4.8 5.5 6.9 4.7 5.5 6.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Band_3_cyto PF07565.13 CDI80713.1 - 4.9 6.9 19.2 5.6 6.7 19.2 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4407 PF14362.6 CDI80713.1 - 5.5 6.2 19.5 6 6.1 19.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CLN3 PF02487.17 CDI80713.1 - 5.9 5.8 11.4 6.3 5.7 11.4 1.1 1 0 0 1 1 1 0 CLN3 protein DUF2828 PF11443.8 CDI80713.1 - 6.4 4.7 15.7 7 4.6 15.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) V_ATPase_I PF01496.19 CDI80713.1 - 6.6 4.5 17.1 6.6 4.5 17.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ureide_permease PF07168.11 CDI80713.1 - 6.9 5.3 6.1 8.2 5.1 6.1 1.1 1 0 0 1 1 1 0 Ureide permease Peptidase_S15 PF02129.18 CDI80713.1 - 7.4 6.1 14.0 8.2 5.9 14.0 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Neur_chan_memb PF02932.16 CDI80713.1 - 7.8 6.5 13.9 8.4 6.4 13.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CSG2 PF16965.5 CDI80713.1 - 8.6 5.2 8.6 8.7 5.2 8.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator FAM60A PF15396.6 CDI80713.1 - 9 6.2 13.2 10 6.1 13.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A AMP-binding PF00501.28 CDI80725.1 - 0.053 12.1 12.0 0.074 11.6 12.0 1.2 1 0 0 1 1 1 0 AMP-binding enzyme DUF4746 PF15928.5 CDI80725.1 - 0.18 11.2 26.5 0.19 11.1 26.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Presenilin PF01080.17 CDI80725.1 - 0.18 10.5 46.3 0.2 10.4 46.3 1.2 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 CDI80725.1 - 0.19 10.1 17.6 0.28 9.5 17.6 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RR_TM4-6 PF06459.12 CDI80725.1 - 0.22 11.3 38.2 0.27 11.0 38.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Otopetrin PF03189.13 CDI80725.1 - 0.65 8.7 21.1 0.96 8.2 21.1 1.3 1 0 0 1 1 1 0 Otopetrin CCSAP PF15748.5 CDI80725.1 - 0.79 9.8 41.8 0.93 9.6 41.8 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Caldesmon PF02029.15 CDI80725.1 - 1.5 7.5 42.1 1.5 7.5 42.1 1.1 1 0 0 1 1 1 0 Caldesmon Endostatin PF06482.11 CDI80725.1 - 1.6 8.1 31.3 1.9 7.8 31.3 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin ALMT PF11744.8 CDI80725.1 - 1.9 7.2 29.9 1.9 7.2 29.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2052 PF09747.9 CDI80725.1 - 2 8.5 39.6 2.3 8.3 39.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PA26 PF04636.13 CDI80725.1 - 2.1 7.2 29.6 2.3 7.1 29.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PPP4R2 PF09184.11 CDI80725.1 - 2.3 7.7 22.6 2.6 7.5 22.6 1.2 1 0 0 1 1 1 0 PPP4R2 CDC45 PF02724.14 CDI80725.1 - 2.7 6.2 37.5 2.9 6.1 37.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Asp-B-Hydro_N PF05279.11 CDI80725.1 - 5.1 7.1 31.0 5.3 7.0 31.0 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4045 PF13254.6 CDI80725.1 - 5.5 6.5 35.9 6.3 6.3 35.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Miga PF10265.9 CDI80725.1 - 5.7 5.8 23.2 6.7 5.6 23.2 1.1 1 0 0 1 1 1 0 Mitoguardin IHABP4_N PF16174.5 CDI80725.1 - 8.1 7.0 49.5 13 6.4 49.5 1.3 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Spt20 PF12090.8 CDI80726.1 - 0.00042 20.0 11.9 0.00056 19.6 11.9 1.3 1 0 0 1 1 1 1 Spt20 family Mus7 PF09462.10 CDI80726.1 - 0.007 15.3 1.8 0.0074 15.2 1.8 1.1 1 0 0 1 1 1 1 Mus7/MMS22 family Macoilin PF09726.9 CDI80726.1 - 0.0078 14.8 15.1 0.012 14.3 15.1 1.3 1 0 0 1 1 1 1 Macoilin family SelP_N PF04592.14 CDI80726.1 - 0.02 14.3 16.9 0.018 14.5 13.2 2.2 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF3984 PF13136.6 CDI80726.1 - 0.022 14.2 12.1 0.028 13.8 12.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) Peptidase_S49_N PF08496.10 CDI80726.1 - 0.022 14.8 4.9 0.035 14.2 4.9 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SOBP PF15279.6 CDI80726.1 - 0.055 14.1 22.3 0.08 13.5 22.3 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Otopetrin PF03189.13 CDI80726.1 - 0.073 11.9 1.0 0.071 11.9 1.0 1.1 1 0 0 1 1 1 0 Otopetrin AF-4 PF05110.13 CDI80726.1 - 0.4 8.7 21.5 0.53 8.3 21.5 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Roughex PF06020.11 CDI80726.1 - 0.43 9.6 7.6 0.81 8.7 7.6 1.5 1 0 0 1 1 1 0 Drosophila roughex protein DUF4834 PF16118.5 CDI80726.1 - 0.48 11.4 6.5 0.85 10.6 6.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4820 PF16091.5 CDI80726.1 - 0.49 9.7 5.3 0.7 9.2 5.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) EIIBC-GUT_N PF03612.14 CDI80726.1 - 0.55 9.9 4.8 0.92 9.2 4.8 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus NEMP PF10225.9 CDI80726.1 - 1.8 8.1 3.9 2.7 7.6 3.9 1.2 1 0 0 1 1 1 0 NEMP family ALMT PF11744.8 CDI80726.1 - 2.3 7.0 10.1 2.8 6.7 10.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 CDI80726.1 - 2.7 8.0 8.5 3.9 7.4 8.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MMR1 PF08505.10 CDI80726.1 - 3.7 7.8 13.5 4.8 7.4 13.5 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DivIC PF04977.15 CDI80726.1 - 7.9 6.3 14.1 1.5 8.7 10.2 1.7 2 0 0 2 2 2 0 Septum formation initiator TFIIA PF03153.13 CDI80737.1 - 0.0001 22.4 45.1 0.0001 22.4 45.1 3.8 3 1 1 4 4 4 2 Transcription factor IIA, alpha/beta subunit PNISR PF15996.5 CDI80737.1 - 0.0024 18.2 17.5 0.0024 18.2 17.5 4.6 3 1 0 4 4 4 1 Arginine/serine-rich protein PNISR DUF2722 PF10846.8 CDI80740.1 - 0.00034 19.7 10.0 0.00034 19.7 10.0 17.9 11 5 4 15 15 15 4 Protein of unknown function (DUF2722) SR-25 PF10500.9 CDI80740.1 - 0.0012 18.6 11.1 0.0012 18.6 11.1 16.3 10 4 3 15 15 15 2 Nuclear RNA-splicing-associated protein DUF4834 PF16118.5 CDI80740.1 - 0.003 18.5 5.1 0.003 18.5 5.1 18.6 11 7 1 13 13 13 1 Domain of unknown function (DUF4834) DUF5523 PF17661.1 CDI80743.1 - 0.034 13.8 13.8 0.035 13.8 13.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Velvet PF11754.8 CDI80743.1 - 0.034 14.1 19.0 0.038 13.9 19.0 1.1 1 0 0 1 1 1 0 Velvet factor eIF-3_zeta PF05091.12 CDI80743.1 - 0.037 13.0 21.0 0.039 13.0 21.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SID-1_RNA_chan PF13965.6 CDI80743.1 - 0.1 11.0 5.4 0.1 11.0 5.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SpoIIP PF07454.11 CDI80743.1 - 0.1 12.0 17.7 0.11 11.9 17.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CDC45 PF02724.14 CDI80743.1 - 0.15 10.3 10.5 0.15 10.3 10.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.8 CDI80743.1 - 0.16 10.8 15.6 0.16 10.7 15.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2126 PF09899.9 CDI80743.1 - 0.22 9.5 12.1 0.21 9.6 12.1 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Baculo_PP31 PF05311.11 CDI80743.1 - 0.23 10.9 13.5 0.25 10.8 13.5 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) RR_TM4-6 PF06459.12 CDI80743.1 - 0.23 11.3 19.1 0.25 11.1 19.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Lin-8 PF03353.15 CDI80743.1 - 0.24 11.0 18.3 0.23 11.0 18.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Endostatin PF06482.11 CDI80743.1 - 0.25 10.8 18.9 0.27 10.6 18.9 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SelP_N PF04592.14 CDI80743.1 - 0.27 10.6 19.1 0.31 10.4 19.1 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region FAM60A PF15396.6 CDI80743.1 - 0.35 10.9 12.7 0.4 10.7 12.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A FHIPEP PF00771.20 CDI80743.1 - 0.38 9.2 11.4 0.46 8.9 11.4 1.1 1 0 0 1 1 1 0 FHIPEP family SLC12 PF03522.15 CDI80743.1 - 0.39 9.7 16.6 0.4 9.6 16.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DDHD PF02862.17 CDI80743.1 - 0.45 10.6 17.8 0.58 10.3 17.8 1.2 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 CDI80743.1 - 0.49 10.4 13.2 0.54 10.3 13.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CSG2 PF16965.5 CDI80743.1 - 0.53 9.2 8.2 0.49 9.3 8.2 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF1387 PF07139.11 CDI80743.1 - 0.55 9.9 16.6 0.6 9.8 16.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Connexin PF00029.19 CDI80743.1 - 0.63 9.8 14.1 0.78 9.5 14.1 1.1 1 0 0 1 1 1 0 Connexin Peptidase_S49_N PF08496.10 CDI80743.1 - 0.68 10.0 11.8 0.86 9.7 11.8 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal TFIIA PF03153.13 CDI80743.1 - 0.71 9.8 52.2 0.95 9.4 52.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Paf1 PF03985.13 CDI80743.1 - 0.72 8.8 19.6 0.83 8.6 19.6 1.1 1 0 0 1 1 1 0 Paf1 PAT1 PF09770.9 CDI80743.1 - 0.75 8.0 35.6 0.82 7.9 35.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TCP PF03634.13 CDI80743.1 - 0.75 10.3 18.5 0.95 10.0 18.5 1.2 1 0 0 1 1 1 0 TCP family transcription factor CLN3 PF02487.17 CDI80743.1 - 0.83 8.6 12.2 0.84 8.6 12.2 1.1 1 0 0 1 1 1 0 CLN3 protein NARP1 PF12569.8 CDI80743.1 - 0.83 8.5 19.4 0.98 8.2 19.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Sec62 PF03839.16 CDI80743.1 - 0.83 9.1 12.0 0.9 9.0 12.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 ALMT PF11744.8 CDI80743.1 - 0.86 8.4 11.6 0.84 8.4 11.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SprA-related PF12118.8 CDI80743.1 - 0.87 8.7 42.1 1.2 8.2 42.1 1.2 1 0 0 1 1 1 0 SprA-related family DUF1980 PF09323.10 CDI80743.1 - 1 9.2 12.0 1.2 9.1 12.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF4603 PF15376.6 CDI80743.1 - 1 6.6 12.6 1.3 6.3 12.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) DUF913 PF06025.12 CDI80743.1 - 1.4 7.9 13.8 1.5 7.7 13.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) BAF1_ABF1 PF04684.13 CDI80743.1 - 1.4 7.9 23.0 1.9 7.5 23.0 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Presenilin PF01080.17 CDI80743.1 - 1.5 7.6 25.9 1.6 7.4 25.9 1.1 1 0 0 1 1 1 0 Presenilin Serinc PF03348.15 CDI80743.1 - 1.6 7.6 13.1 1.7 7.5 13.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Zip PF02535.22 CDI80743.1 - 1.9 7.6 12.1 2.2 7.4 12.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NEMP PF10225.9 CDI80743.1 - 2 8.0 6.0 2.4 7.8 6.0 1.1 1 0 0 1 1 1 0 NEMP family MMR1 PF08505.10 CDI80743.1 - 2.1 8.5 24.1 2.6 8.3 24.1 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein MDM10 PF12519.8 CDI80743.1 - 2.5 6.9 14.4 2.6 6.8 14.4 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DcuA_DcuB PF03605.14 CDI80743.1 - 2.9 6.7 10.7 3.9 6.3 10.7 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF5427 PF10310.9 CDI80743.1 - 3 6.7 25.3 3.6 6.4 25.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) NPR3 PF03666.13 CDI80743.1 - 3.5 6.3 19.0 4.6 5.9 19.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 OATP PF03137.20 CDI80743.1 - 3.5 5.8 9.2 3.7 5.7 9.2 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CCSAP PF15748.5 CDI80743.1 - 3.6 7.7 25.9 4.4 7.4 25.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Hamartin PF04388.12 CDI80743.1 - 3.8 6.1 20.9 4.3 5.9 20.9 1.0 1 0 0 1 1 1 0 Hamartin protein DUF4045 PF13254.6 CDI80743.1 - 4.1 6.9 25.9 4.7 6.8 25.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Macoilin PF09726.9 CDI80743.1 - 4.2 5.8 16.8 5 5.6 16.8 1.1 1 0 0 1 1 1 0 Macoilin family DUF4746 PF15928.5 CDI80743.1 - 4.3 6.7 13.1 5 6.4 13.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Rrn6 PF10214.9 CDI80743.1 - 4.4 5.7 23.1 4.1 5.8 23.1 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Cellulose_synt PF03552.14 CDI80743.1 - 4.7 5.6 6.7 5 5.5 6.7 1.0 1 0 0 1 1 1 0 Cellulose synthase Peptidase_U57 PF05582.12 CDI80743.1 - 4.8 6.4 12.3 6 6.0 12.3 1.2 1 0 0 1 1 1 0 YabG peptidase U57 SAPS PF04499.15 CDI80743.1 - 5.5 5.7 16.2 5.8 5.6 16.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Band_3_cyto PF07565.13 CDI80743.1 - 5.6 6.7 19.6 7.2 6.3 19.6 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain HCO3_cotransp PF00955.21 CDI80743.1 - 5.6 5.7 8.3 5.9 5.6 8.3 1.1 1 0 0 1 1 1 0 HCO3- transporter family Pannexin_like PF12534.8 CDI80743.1 - 6.2 5.8 14.9 8.9 5.3 14.9 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 O-antigen_lig PF13425.6 CDI80743.1 - 7.1 5.3 7.1 7.5 5.2 7.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Hid1 PF12722.7 CDI80743.1 - 7.1 4.6 21.0 7 4.6 21.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2828 PF11443.8 CDI80743.1 - 7.2 4.6 19.3 8.8 4.3 19.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Peptidase_S64 PF08192.11 CDI80743.1 - 9.1 4.6 16.3 10 4.4 16.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 V_ATPase_I PF01496.19 CDI80743.1 - 10 3.9 22.0 12 3.6 22.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4781 PF16013.5 CDI80749.1 - 0.00028 19.8 0.4 0.00037 19.4 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4781) Yip1 PF04893.17 CDI80749.1 - 0.019 14.7 4.9 0.024 14.4 4.9 1.1 1 0 0 1 1 1 0 Yip1 domain DUF1129 PF06570.11 CDI80749.1 - 0.11 12.0 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) RskA PF10099.9 CDI80749.1 - 0.31 11.3 16.8 0.43 10.9 16.8 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA RIFIN PF02009.16 CDI80749.1 - 1.3 8.8 6.9 1.9 8.3 6.9 1.2 1 0 0 1 1 1 0 Rifin DUF4813 PF16072.5 CDI80749.1 - 5.6 6.6 25.7 7.4 6.1 25.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Glyco_hydro_9 PF00759.19 CDI80749.1 - 8.7 5.7 14.2 12 5.2 14.2 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 Sin_N PF04801.13 CDI80761.1 - 0.00013 21.3 16.3 0.00013 21.3 16.3 1.9 2 0 0 2 2 2 1 Sin-like protein conserved region Lin-8 PF03353.15 CDI80761.1 - 0.014 15.0 14.6 0.022 14.3 14.6 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Connexin PF00029.19 CDI80761.1 - 0.037 13.8 3.2 0.072 12.8 3.2 1.4 1 0 0 1 1 1 0 Connexin MCM_bind PF09739.9 CDI80761.1 - 0.096 11.1 12.1 0.15 10.5 12.1 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF913 PF06025.12 CDI80761.1 - 0.24 10.3 5.1 0.4 9.6 5.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SID-1_RNA_chan PF13965.6 CDI80761.1 - 0.35 9.2 0.9 0.47 8.8 0.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI80761.1 - 0.43 9.4 2.3 0.74 8.7 2.3 1.5 1 0 0 1 1 1 0 Serine incorporator (Serinc) V_ATPase_I PF01496.19 CDI80761.1 - 0.46 8.3 16.2 0.79 7.6 16.2 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GREB1 PF15782.5 CDI80761.1 - 0.81 6.7 10.6 0.94 6.5 10.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ndc1_Nup PF09531.10 CDI80761.1 - 1.1 7.9 13.5 1.9 7.1 13.5 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 CDI80761.1 - 1.3 7.2 28.8 2.4 6.3 28.8 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDC45 PF02724.14 CDI80761.1 - 1.3 7.2 15.2 1.9 6.7 15.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S64 PF08192.11 CDI80761.1 - 1.3 7.4 10.8 1.7 7.1 10.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF3292 PF11696.8 CDI80761.1 - 2.5 6.4 13.5 6 5.1 13.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) LMBR1 PF04791.16 CDI80761.1 - 3 6.7 3.4 4.2 6.2 3.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein CLN3 PF02487.17 CDI80761.1 - 4.5 6.2 8.7 8.7 5.3 8.7 1.5 1 0 0 1 1 1 0 CLN3 protein Otopetrin PF03189.13 CDI80761.1 - 6.7 5.4 6.3 11 4.7 6.3 1.4 1 0 0 1 1 1 0 Otopetrin FAM176 PF14851.6 CDI80761.1 - 8.7 6.0 10.9 22 4.7 10.9 1.7 1 0 0 1 1 1 0 FAM176 family EIF4E-T PF10477.9 CDI80777.1 - 0.95 8.2 34.7 0.29 9.9 13.0 2.3 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Lin-8 PF03353.15 CDI80777.1 - 6.9 6.1 34.5 4.2 6.8 11.1 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist HSBP1 PF06825.12 CDI80781.1 - 3.5e-09 36.4 0.2 7.4e-09 35.3 0.2 1.6 1 0 0 1 1 1 1 Heat shock factor binding protein 1 SUIM_assoc PF16619.5 CDI80781.1 - 0.029 14.4 8.7 0.029 14.4 8.7 6.2 4 2 1 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 Sporozoite_P67 PF05642.11 CDI80781.1 - 0.32 9.0 14.8 0.03 12.4 3.1 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DUF572 PF04502.13 CDI80781.1 - 2.3 7.7 28.7 0.52 9.9 9.5 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) Ndc1_Nup PF09531.10 CDI80781.1 - 8.8 4.9 32.1 0.12 11.0 8.8 2.4 2 1 0 2 2 2 0 Nucleoporin protein Ndc1-Nup DUF179 PF02622.15 CDI80802.1 - 1.6e-09 38.0 1.1 2.6e-06 27.5 0.2 2.8 2 0 0 2 2 2 2 Uncharacterized ACR, COG1678 DUF5523 PF17661.1 CDI80802.1 - 0.38 10.4 19.8 0.27 10.9 10.6 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Connexin PF00029.19 CDI80802.1 - 1.8 8.3 16.0 0.37 10.5 6.6 2.6 2 0 0 2 2 2 0 Connexin SpoIIP PF07454.11 CDI80802.1 - 3.3 7.1 25.0 0.057 12.9 9.7 3.1 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) RRM_1 PF00076.22 CDI80803.1 - 1.8e-07 30.9 0.0 3.1e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SR-25 PF10500.9 CDI80803.1 - 0.011 15.4 24.5 0.011 15.4 24.5 1.7 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI80803.1 - 0.011 15.7 20.4 0.012 15.6 20.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1635 PF07795.11 CDI80803.1 - 0.015 15.2 11.1 0.024 14.5 9.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Hamartin PF04388.12 CDI80803.1 - 0.35 9.5 18.5 0.39 9.3 18.5 1.0 1 0 0 1 1 1 0 Hamartin protein Lin-8 PF03353.15 CDI80803.1 - 0.58 9.7 11.0 1 8.9 10.9 1.6 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist GREB1 PF15782.5 CDI80803.1 - 1.9 5.5 16.5 2.4 5.2 16.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Nucleo_P87 PF07267.11 CDI80803.1 - 3.9 6.2 12.8 4.6 6.0 12.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Macoilin PF09726.9 CDI80803.1 - 5.5 5.4 16.0 6.5 5.2 16.0 1.2 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 CDI80803.1 - 5.8 6.0 19.5 7.3 5.7 19.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF2464 PF10240.9 CDI80803.1 - 6.6 6.2 12.5 23 4.4 12.5 1.8 1 1 0 1 1 1 0 Multivesicular body subunit 12 RskA PF10099.9 CDI80805.1 - 0.00082 19.7 4.7 0.00082 19.7 4.7 9.0 1 1 4 6 6 6 2 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI80805.1 - 0.0013 18.8 6.3 0.0013 18.8 6.3 17.4 8 5 1 9 9 9 1 Unstructured region C-term to UIM in Ataxin3 Metallophos PF00149.28 CDI80805.1 - 0.02 15.4 0.0 0.33 11.4 0.0 2.6 2 1 0 2 2 2 0 Calcineurin-like phosphoesterase zf-C4_ClpX PF06689.13 CDI80807.1 - 0.0069 16.2 3.1 0.012 15.5 3.1 1.3 1 0 0 1 1 1 1 ClpX C4-type zinc finger Utp14 PF04615.13 CDI80807.1 - 9.5 4.7 16.8 13 4.2 16.8 1.1 1 0 0 1 1 1 0 Utp14 protein APC_u13 PF16634.5 CDI80810.1 - 1.5 8.8 4.8 6.7 6.7 0.8 2.7 1 1 1 2 2 2 0 Unstructured region on APC between APC_crr and SAMP SSP160 PF06933.11 CDI80814.1 - 1.4 7.1 13.2 1.7 6.8 13.2 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 SMYLE_N PF18615.1 CDI80814.1 - 2 7.9 40.1 3.1 7.3 40.1 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain CDC27 PF09507.10 CDI80814.1 - 3 7.1 53.7 4.2 6.7 53.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 AF-4 PF05110.13 CDI80814.1 - 5.6 4.9 65.8 8.9 4.3 65.8 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Spt20 PF12090.8 CDI80823.1 - 0.00016 21.4 22.6 0.0002 21.1 22.6 1.2 1 0 0 1 1 1 1 Spt20 family MMR1 PF08505.10 CDI80823.1 - 0.0026 18.1 14.6 0.0032 17.8 14.6 1.1 1 0 0 1 1 1 1 Mitochondrial Myo2 receptor-related protein UPF0560 PF10577.9 CDI80823.1 - 0.0029 16.2 8.4 0.0032 16.1 8.4 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0560 CNDH2_C PF16858.5 CDI80823.1 - 0.009 15.9 6.6 0.011 15.7 6.6 1.2 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF4647 PF15504.6 CDI80823.1 - 0.019 14.1 9.6 0.021 14.0 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) TFIIF_alpha PF05793.12 CDI80823.1 - 0.038 12.6 10.3 0.046 12.3 10.3 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4746 PF15928.5 CDI80823.1 - 0.073 12.5 3.8 0.075 12.4 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF2681 PF10883.8 CDI80823.1 - 0.11 13.0 17.9 0.32 11.4 17.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) MPM1 PF17234.2 CDI80823.1 - 0.22 11.8 12.3 0.31 11.3 12.3 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 DNApol_Exo PF18136.1 CDI80823.1 - 0.24 10.5 8.9 0.37 9.9 8.9 1.3 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain UPF0524 PF15823.5 CDI80823.1 - 0.29 10.5 7.9 0.45 9.9 7.9 1.3 1 0 0 1 1 1 0 UPF0524 of C3orf70 Plasmodium_Vir PF05795.11 CDI80823.1 - 0.36 10.2 8.3 0.46 9.9 8.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Apt1 PF10351.9 CDI80823.1 - 0.37 9.6 10.3 0.38 9.6 10.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 CDI80823.1 - 0.48 9.9 16.7 0.6 9.6 16.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Nop53 PF07767.11 CDI80823.1 - 0.5 9.7 21.0 0.66 9.3 21.0 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SLC12 PF03522.15 CDI80823.1 - 0.52 9.3 11.8 0.62 9.0 11.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Connexin PF00029.19 CDI80823.1 - 0.58 9.9 5.0 0.74 9.5 5.0 1.2 1 0 0 1 1 1 0 Connexin Neur_chan_memb PF02932.16 CDI80823.1 - 0.69 9.9 8.3 0.78 9.7 8.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NEMP PF10225.9 CDI80823.1 - 0.99 9.0 4.9 1.4 8.6 4.9 1.3 1 0 0 1 1 1 0 NEMP family NPR3 PF03666.13 CDI80823.1 - 1.1 8.0 11.0 1.2 7.8 11.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Paf1 PF03985.13 CDI80823.1 - 1.1 8.2 13.1 1.4 7.8 13.1 1.1 1 0 0 1 1 1 0 Paf1 Paramyxo_ncap PF00973.19 CDI80823.1 - 1.2 8.0 9.1 1.3 7.9 9.1 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Membralin PF09746.9 CDI80823.1 - 1.7 7.6 4.9 2 7.4 4.9 1.1 1 0 0 1 1 1 0 Tumour-associated protein MAP65_ASE1 PF03999.12 CDI80823.1 - 2.4 6.8 16.6 2.7 6.6 16.6 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DivIC PF04977.15 CDI80823.1 - 2.4 8.0 15.2 5.8 6.8 15.2 1.6 1 0 0 1 1 1 0 Septum formation initiator SID-1_RNA_chan PF13965.6 CDI80823.1 - 2.5 6.4 4.5 3 6.2 4.5 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Miga PF10265.9 CDI80823.1 - 2.5 6.9 15.5 3.1 6.7 15.5 1.1 1 0 0 1 1 1 0 Mitoguardin Hid1 PF12722.7 CDI80823.1 - 2.8 6.0 17.4 3.1 5.8 17.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein EMC3_TMCO1 PF01956.16 CDI80823.1 - 2.8 7.6 6.3 3.9 7.2 6.3 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Draxin PF15550.6 CDI80823.1 - 4 7.2 16.0 1.8 8.4 14.0 1.4 1 1 0 1 1 1 0 Draxin V_ATPase_I PF01496.19 CDI80823.1 - 4.6 5.0 10.7 6.1 4.6 10.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mitofilin PF09731.9 CDI80823.1 - 5.2 5.8 31.3 6.1 5.6 31.3 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF1980 PF09323.10 CDI80823.1 - 5.9 6.8 8.1 9.2 6.1 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF2981 PF11200.8 CDI80823.1 - 6 6.5 10.8 7.2 6.3 10.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Peptidase_S64 PF08192.11 CDI80823.1 - 6 5.2 17.3 6.9 5.0 17.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 ALMT PF11744.8 CDI80823.1 - 6.3 5.5 12.1 7.7 5.2 12.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Otopetrin PF03189.13 CDI80823.1 - 7.7 5.2 7.5 8.9 5.0 7.5 1.2 1 0 0 1 1 1 0 Otopetrin N6_N4_Mtase PF01555.18 CDI80830.1 - 0.00068 19.4 4.1 0.39 10.4 4.1 3.2 1 1 0 1 1 1 1 DNA methylase Conotoxin PF02950.17 CDI80830.1 - 0.022 15.8 1.8 0.022 15.8 1.8 5.9 3 2 1 4 4 4 0 Conotoxin EphA2_TM PF14575.6 CDI80830.1 - 0.2 12.5 0.3 0.2 12.5 0.3 6.2 3 2 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain SR-25 PF10500.9 CDI80837.1 - 1.9e-05 24.4 19.8 1.9e-05 24.4 19.8 3.1 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI80837.1 - 0.00037 20.9 28.8 0.081 13.2 16.2 3.0 1 1 1 2 2 2 2 Anti-sigma-K factor rskA Zip PF02535.22 CDI80837.1 - 0.0005 19.4 3.1 0.0005 19.4 3.1 2.9 2 1 1 3 3 3 1 ZIP Zinc transporter Pex14_N PF04695.13 CDI80837.1 - 0.0013 19.4 15.5 0.0013 19.4 15.5 3.5 2 1 0 2 2 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 CDI80837.1 - 0.0023 16.7 34.0 0.0024 16.7 7.1 2.4 2 0 0 2 2 2 2 Presenilin Cwf_Cwc_15 PF04889.12 CDI80837.1 - 0.0059 16.4 30.5 0.027 14.2 16.0 2.1 2 0 0 2 2 2 2 Cwf15/Cwc15 cell cycle control protein SprA-related PF12118.8 CDI80837.1 - 0.066 12.3 61.3 0.059 12.5 31.0 2.3 2 0 0 2 2 2 0 SprA-related family RR_TM4-6 PF06459.12 CDI80837.1 - 0.99 9.2 30.2 0.66 9.7 8.8 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 SelP_N PF04592.14 CDI80837.1 - 1.8 7.9 37.9 0.099 12.0 17.6 2.4 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Caldesmon PF02029.15 CDI80837.1 - 1.9 7.2 31.1 0.26 10.0 13.1 2.2 2 0 0 2 2 2 0 Caldesmon Raftlin PF15250.6 CDI80837.1 - 2 7.1 29.2 0.051 12.3 4.7 2.2 2 0 0 2 2 2 0 Raftlin rRNA_processing PF08524.11 CDI80837.1 - 2.2 8.3 36.7 3 7.9 15.7 2.5 2 0 0 2 2 2 0 rRNA processing Na_trans_assoc PF06512.13 CDI80837.1 - 5.7 7.2 17.9 7.3 6.8 1.3 2.2 2 0 0 2 2 2 0 Sodium ion transport-associated IMUP PF15761.5 CDI80837.1 - 6.4 7.5 48.1 0.13 13.0 14.5 3.4 2 1 1 3 3 3 0 Immortalisation up-regulated protein FAM60A PF15396.6 CDI80837.1 - 7.1 6.6 31.9 5.4 7.0 10.5 2.4 2 0 0 2 2 2 0 Protein Family FAM60A DUF3984 PF13136.6 CDI80837.1 - 7.3 5.9 48.9 0.22 10.9 21.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3984) Spt20 PF12090.8 CDI80838.1 - 0.0022 17.7 19.3 0.0022 17.7 19.3 2.9 2 1 0 2 2 1 1 Spt20 family Pinin_SDK_memA PF04696.13 CDI80838.1 - 0.0048 17.0 27.1 0.0048 17.0 27.1 2.1 2 0 0 2 2 2 1 pinin/SDK/memA/ protein conserved region eIF3_subunit PF08597.10 CDI80838.1 - 0.013 15.4 14.6 0.013 15.4 14.6 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit RR_TM4-6 PF06459.12 CDI80838.1 - 0.16 11.8 29.0 0.75 9.6 18.9 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF3807 PF12720.7 CDI80838.1 - 0.19 12.0 38.4 0.59 10.4 5.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) AUX_IAA PF02309.16 CDI80838.1 - 0.25 11.2 16.9 0.41 10.4 16.9 1.3 1 1 0 1 1 1 0 AUX/IAA family CCDC53 PF10152.9 CDI80838.1 - 0.31 11.5 32.4 1.9 8.9 3.5 2.1 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex DUF3408 PF11888.8 CDI80838.1 - 0.34 11.1 31.2 0.99 9.5 19.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) DUF3464 PF11947.8 CDI80838.1 - 0.72 9.6 30.1 1 9.1 16.3 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DUF4628 PF15429.6 CDI80838.1 - 0.82 9.3 24.4 0.42 10.2 12.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4628) CSRNP_N PF16019.5 CDI80838.1 - 1.5 8.7 29.2 0.65 9.9 15.0 2.1 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus TERB2 PF15101.6 CDI80838.1 - 2.1 8.3 42.6 2 8.4 8.5 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 FAM176 PF14851.6 CDI80838.1 - 3 7.5 21.6 2 8.0 12.2 2.2 2 0 0 2 2 2 0 FAM176 family FYDLN_acid PF09538.10 CDI80838.1 - 4.9 7.9 23.6 11 6.8 14.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) CLN3 PF02487.17 CDI80838.1 - 6.5 5.7 25.3 1.1 8.2 14.2 2.0 2 0 0 2 2 2 0 CLN3 protein Tim54 PF11711.8 CDI80838.1 - 6.7 5.4 30.3 2.3 6.9 18.4 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF1764 PF08576.10 CDI80838.1 - 6.7 7.7 30.7 3.7 8.5 16.4 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) HABP4_PAI-RBP1 PF04774.15 CDI80838.1 - 7.5 7.4 31.0 1.3 9.9 16.5 2.1 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family DUF755 PF05501.11 CDI80842.1 - 0.00053 20.3 19.7 0.00053 20.3 19.7 4.2 4 0 0 4 4 4 1 Domain of unknown function (DUF755) SART-1 PF03343.13 CDI80842.1 - 1.2 7.6 34.1 2.7 6.4 34.1 1.6 1 0 0 1 1 1 0 SART-1 family DUF4638 PF15472.6 CDI80842.1 - 7.1 6.3 20.2 6.4 6.4 9.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) TatD_DNase PF01026.21 CDI80858.1 - 1.9e-41 142.1 0.0 2.6e-41 141.7 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase MID_MedPIWI PF18296.1 CDI80858.1 - 0.0039 17.0 0.5 0.0057 16.5 0.5 1.3 1 0 0 1 1 1 1 MID domain of medPIWI FAM199X PF15814.5 CDI80858.1 - 0.012 14.7 3.5 0.018 14.1 3.5 1.2 1 0 0 1 1 1 0 Protein family FAM199X Corona_nucleoca PF00937.18 CDI80858.1 - 0.062 12.3 2.8 0.11 11.5 2.8 1.4 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Secretin_N_2 PF07655.13 CDI80858.1 - 0.12 12.9 11.1 0.42 11.2 11.2 1.8 2 0 0 2 2 2 0 Secretin N-terminal domain RAP1 PF07218.11 CDI80858.1 - 0.14 10.4 2.2 0.17 10.1 2.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DAG_kinase_N PF14513.6 CDI80858.1 - 2 8.6 9.2 0.19 11.9 0.3 2.2 1 1 1 2 2 2 0 Diacylglycerol kinase N-terminus K_channel_TID PF07941.11 CDI80860.1 - 0.036 14.5 8.2 0.036 14.5 8.2 4.9 4 2 0 4 4 4 0 Potassium channel Kv1.4 tandem inactivation domain Ribosomal_60s PF00428.19 CDI80860.1 - 0.64 10.6 22.2 2.2 8.9 3.4 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein SID-1_RNA_chan PF13965.6 CDI80860.1 - 4.7 5.5 8.1 6.2 5.1 8.1 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SMYLE_N PF18615.1 CDI80860.1 - 7.1 6.1 26.0 10 5.5 26.0 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain SUIM_assoc PF16619.5 CDI80862.1 - 0.0037 17.3 7.4 0.0037 17.3 7.4 15.9 8 3 6 14 14 14 3 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI80869.1 - 0.00011 22.6 8.6 0.014 15.7 3.9 2.3 2 1 0 2 2 2 2 Anti-sigma-K factor rskA CDC45 PF02724.14 CDI80872.1 - 4.1e-05 22.1 21.0 5.1e-05 21.8 21.0 1.1 1 0 0 1 1 1 1 CDC45-like protein Presenilin PF01080.17 CDI80872.1 - 8.7e-05 21.5 27.4 0.00011 21.1 27.4 1.1 1 0 0 1 1 1 1 Presenilin GAGA_bind PF06217.12 CDI80872.1 - 0.031 14.6 24.8 0.043 14.1 24.8 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Hid1 PF12722.7 CDI80872.1 - 0.048 11.8 25.5 0.058 11.5 25.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Caldesmon PF02029.15 CDI80872.1 - 0.079 11.7 31.3 0.098 11.4 31.3 1.1 1 0 0 1 1 1 0 Caldesmon AUX_IAA PF02309.16 CDI80872.1 - 0.082 12.7 14.8 0.13 12.1 14.8 1.4 1 0 0 1 1 1 0 AUX/IAA family CAC1F_C PF16885.5 CDI80872.1 - 0.11 12.2 16.1 0.13 11.9 16.1 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term TPK_catalytic PF04263.16 CDI80872.1 - 0.16 12.0 8.5 0.62 10.1 8.5 2.0 1 1 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain SLC12 PF03522.15 CDI80872.1 - 0.17 10.8 30.3 0.23 10.4 30.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 LAP1C PF05609.12 CDI80872.1 - 0.18 10.9 27.1 0.21 10.6 27.1 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Macoilin PF09726.9 CDI80872.1 - 0.19 10.3 21.3 0.33 9.5 21.3 1.4 1 0 0 1 1 1 0 Macoilin family PAT1 PF09770.9 CDI80872.1 - 0.33 9.2 50.9 0.39 8.9 50.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI80872.1 - 0.35 7.9 24.7 0.41 7.7 24.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Exonuc_VII_L PF02601.15 CDI80872.1 - 0.39 10.2 29.1 0.48 10.0 29.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit SARAF PF06682.12 CDI80872.1 - 0.43 10.2 0.0 0.43 10.2 0.0 2.2 1 1 1 2 2 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4045 PF13254.6 CDI80872.1 - 0.44 10.1 24.7 0.64 9.6 24.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) AF-4 PF05110.13 CDI80872.1 - 0.51 8.4 37.9 0.62 8.1 37.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Dicty_REP PF05086.12 CDI80872.1 - 1.3 6.9 14.5 1.6 6.6 14.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein LMBR1 PF04791.16 CDI80872.1 - 1.6 7.6 18.3 2 7.3 18.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein CDK5_activator PF03261.15 CDI80872.1 - 1.7 8.1 26.2 2.1 7.8 26.2 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Ndc1_Nup PF09531.10 CDI80872.1 - 2.7 6.6 25.4 3.5 6.2 25.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup XRN_M PF17846.1 CDI80872.1 - 3.2 6.6 22.7 4.3 6.2 22.7 1.1 1 0 0 1 1 1 0 Xrn1 helical domain RR_TM4-6 PF06459.12 CDI80872.1 - 5.7 6.7 34.1 9.9 5.9 34.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.6 CDI80872.1 - 5.7 6.9 26.6 9.6 6.1 26.6 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Peptidase_S64 PF08192.11 CDI80872.1 - 8.7 4.7 22.8 14 4.0 22.8 1.3 1 0 0 1 1 1 0 Peptidase family S64 Histone PF00125.24 CDI80900.1 - 2.2e-06 28.1 3.3 2.2e-06 28.1 3.3 4.6 2 2 1 4 4 4 2 Core histone H2A/H2B/H3/H4 DUF3381 PF11861.8 CDI80901.1 - 3.5 7.4 15.8 9.6 6.0 7.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Sporozoite_P67 PF05642.11 CDI80901.1 - 8.7 4.3 19.2 0.6 8.1 1.5 2.6 2 1 0 2 2 2 0 Sporozoite P67 surface antigen SDA1 PF05285.12 CDI80902.1 - 0.0036 16.8 52.7 0.032 13.7 11.9 2.1 2 0 0 2 2 2 2 SDA1 Ocnus PF05005.15 CDI80903.1 - 0.00015 21.8 0.0 0.00026 21.1 0.0 1.3 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) MukB_hinge PF16330.5 CDI80903.1 - 0.031 14.0 0.0 0.066 12.9 0.0 1.5 1 0 0 1 1 1 0 MukB hinge domain TPR_21 PF09976.9 CDI80903.1 - 0.11 12.2 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain E1_dh PF00676.20 CDI80905.1 - 1.1e-55 188.8 0.0 1.3e-55 188.5 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 CDI80905.1 - 0.0012 18.7 0.3 0.0088 15.8 0.1 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 CDI80905.1 - 0.014 14.6 0.2 0.028 13.6 0.2 1.5 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_N PF00456.21 CDI80905.1 - 0.098 11.6 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain Sda PF08970.10 CDI80905.1 - 0.19 11.5 0.5 0.4 10.4 0.5 1.5 1 0 0 1 1 1 0 Sporulation inhibitor A SUIM_assoc PF16619.5 CDI80906.1 - 0.00019 21.4 3.1 0.00019 21.4 3.1 5.3 3 1 1 4 4 1 1 Unstructured region C-term to UIM in Ataxin3 Presenilin PF01080.17 CDI80906.1 - 0.0057 15.5 30.6 0.4 9.4 0.2 2.1 2 0 0 2 2 2 2 Presenilin DUF2151 PF10221.9 CDI80906.1 - 0.024 13.3 13.5 0.032 12.9 13.5 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator TRAP_alpha PF03896.16 CDI80906.1 - 0.029 13.6 6.6 0.011 15.0 3.1 1.8 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit eIF-3_zeta PF05091.12 CDI80906.1 - 0.038 13.0 34.9 0.4 9.6 26.6 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) HemX PF04375.14 CDI80906.1 - 0.049 12.9 56.4 0.14 11.4 43.6 2.4 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase BORG_CEP PF14957.6 CDI80906.1 - 0.065 14.4 18.7 1.5 10.0 11.6 2.2 2 0 0 2 2 2 0 Cdc42 effector MAT1 PF06391.13 CDI80906.1 - 0.076 12.8 0.1 0.076 12.8 0.1 2.4 2 1 0 2 2 1 0 CDK-activating kinase assembly factor MAT1 FAM76 PF16046.5 CDI80906.1 - 0.086 12.2 26.5 0.69 9.2 20.2 2.1 2 0 0 2 2 2 0 FAM76 protein MMM1 PF10296.9 CDI80906.1 - 0.099 11.7 14.9 1.7 7.6 9.4 2.3 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 SARAF PF06682.12 CDI80906.1 - 0.12 12.0 26.6 0.14 11.8 16.1 2.1 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis SLC12 PF03522.15 CDI80906.1 - 0.18 10.8 26.7 0.27 10.2 20.8 2.0 2 0 0 2 2 2 0 Solute carrier family 12 DUF2828 PF11443.8 CDI80906.1 - 0.21 9.6 22.5 0.5 8.4 19.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Connexin PF00029.19 CDI80906.1 - 0.23 11.2 18.6 0.18 11.5 12.6 2.3 2 0 0 2 2 2 0 Connexin Gti1_Pac2 PF09729.9 CDI80906.1 - 0.35 10.9 23.0 0.76 9.8 16.4 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family ALMT PF11744.8 CDI80906.1 - 0.48 9.2 20.8 0.3 9.8 14.4 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter CPSF100_C PF13299.6 CDI80906.1 - 0.53 10.4 21.4 1.6 8.9 13.8 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Ctr PF04145.15 CDI80906.1 - 0.65 10.6 19.5 0.49 11.0 13.2 2.3 2 0 0 2 2 2 0 Ctr copper transporter family EPL1 PF10513.9 CDI80906.1 - 0.75 10.2 28.5 3.4 8.0 20.9 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like AAA_11 PF13086.6 CDI80906.1 - 0.78 9.5 28.1 0.39 10.4 20.1 2.1 2 0 0 2 2 2 0 AAA domain CSG2 PF16965.5 CDI80906.1 - 1 8.2 13.6 1.3 7.9 8.8 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator U1snRNP70_N PF12220.8 CDI80906.1 - 1.5 9.5 0.0 1.5 9.5 0.0 3.2 2 1 0 2 2 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Peptidase_S49_N PF08496.10 CDI80906.1 - 1.7 8.7 21.5 16 5.5 17.6 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal PIN_12 PF16289.5 CDI80906.1 - 1.9 8.9 11.8 0.18 12.3 6.9 1.6 2 0 0 2 2 2 0 PIN domain Endostatin PF06482.11 CDI80906.1 - 2.6 7.5 25.6 4.1 6.8 21.0 2.0 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin DUF3492 PF11997.8 CDI80906.1 - 2.7 7.7 13.8 0.34 10.6 8.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3492) Tim54 PF11711.8 CDI80906.1 - 3.4 6.4 20.2 0.85 8.3 14.2 2.0 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 AF-4 PF05110.13 CDI80906.1 - 3.5 5.6 37.0 2.3 6.2 5.4 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Band_3_cyto PF07565.13 CDI80906.1 - 3.8 7.2 28.6 2.5 7.8 18.9 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain YABBY PF04690.13 CDI80906.1 - 3.9 8.0 26.0 4.4 7.9 1.4 2.2 2 0 0 2 2 2 0 YABBY protein RR_TM4-6 PF06459.12 CDI80906.1 - 4 7.2 32.0 2.6 7.8 24.9 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF3292 PF11696.8 CDI80906.1 - 5 5.4 18.5 0.25 9.7 9.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) NST1 PF13945.6 CDI80906.1 - 5 7.2 38.2 0.65 10.1 1.0 2.3 2 0 0 2 2 2 0 Salt tolerance down-regulator Pkinase_fungal PF17667.1 CDI80906.1 - 5.1 5.8 17.8 0.11 11.2 10.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase PA26 PF04636.13 CDI80906.1 - 5.6 5.8 22.5 1.5 7.6 15.9 2.0 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) SpoIIP PF07454.11 CDI80906.1 - 5.7 6.3 27.2 4 6.8 20.1 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) SIT PF15330.6 CDI80906.1 - 5.8 7.4 31.1 8.1 6.9 23.4 2.5 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT WDCP PF15390.6 CDI80906.1 - 5.9 5.1 24.5 8.8 4.6 0.3 2.0 2 0 0 2 2 2 0 WD repeat and coiled-coil-containing protein family DUF2052 PF09747.9 CDI80906.1 - 6.1 6.9 30.6 14 5.8 0.1 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Hamartin PF04388.12 CDI80906.1 - 6.3 5.3 26.0 7.6 5.1 19.4 2.0 2 0 0 2 2 2 0 Hamartin protein CSRNP_N PF16019.5 CDI80906.1 - 6.6 6.6 26.5 6.3 6.7 18.9 2.1 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus Exonuc_VII_L PF02601.15 CDI80906.1 - 8.6 5.8 34.2 15 5.1 28.0 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Trp_oprn_chp PF09534.10 CDI80908.1 - 0.00026 20.8 21.2 0.00026 20.8 21.2 4.2 1 1 2 3 3 3 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Prok-JAB PF14464.6 CDI80908.1 - 0.01 15.6 0.2 0.01 15.6 0.2 3.4 3 1 0 3 3 3 0 Prokaryotic homologs of the JAB domain RskA PF10099.9 CDI80908.1 - 0.019 15.2 2.9 0.019 15.2 2.9 5.7 1 1 2 3 3 3 0 Anti-sigma-K factor rskA CD20 PF04103.15 CDI80908.1 - 0.1 12.7 5.6 0.11 12.6 1.2 2.8 1 1 1 2 2 2 0 CD20-like family DUF1772 PF08592.11 CDI80908.1 - 0.13 12.5 0.0 0.13 12.5 0.0 4.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) DUF2207 PF09972.9 CDI80908.1 - 0.57 8.9 2.0 0.44 9.2 0.1 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) SID-1_RNA_chan PF13965.6 CDI80908.1 - 0.66 8.3 6.7 1.1 7.6 6.7 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 CDI80908.1 - 2 7.3 5.9 3.5 6.5 5.9 1.4 1 0 0 1 1 1 0 Ceramide synthase regulator TMEM208_SND2 PF05620.11 CDI80908.1 - 5.2 6.8 21.5 0.42 10.4 2.3 3.2 2 1 1 3 3 3 0 SRP-independent targeting protein 2/TMEM208 Trp_oprn_chp PF09534.10 CDI80919.1 - 0.0051 16.6 19.7 0.55 10.0 2.4 4.2 4 0 0 4 4 4 3 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PBP1_TM PF14812.6 CDI80919.1 - 0.024 15.0 8.8 1.3 9.4 2.4 3.4 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BAAT_C PF08840.11 CDI80919.1 - 0.03 14.3 0.6 0.17 11.8 0.0 2.4 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal PNISR PF15996.5 CDI80919.1 - 0.031 14.5 1.1 0.031 14.5 1.1 4.0 3 1 0 3 3 2 0 Arginine/serine-rich protein PNISR AAA_23 PF13476.6 CDI80919.1 - 0.066 13.7 0.2 0.066 13.7 0.2 3.1 2 1 0 2 2 1 0 AAA domain MTS PF05175.14 CDI80919.1 - 0.072 12.6 0.3 0.24 10.9 0.2 1.9 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 CDI80919.1 - 0.1 13.3 0.2 0.1 13.3 0.2 3.8 4 1 0 4 4 3 0 Methyltransferase domain SpoVR PF04293.13 CDI80919.1 - 0.13 10.9 14.0 0.036 12.8 5.4 2.4 2 0 0 2 2 2 0 SpoVR like protein Methyltransf_12 PF08242.12 CDI80919.1 - 1.2 10.0 11.6 1.1 10.0 0.3 4.0 3 1 0 3 3 3 0 Methyltransferase domain Methyltransf_11 PF08241.12 CDI80919.1 - 1.7 9.3 7.3 6 7.6 0.1 4.0 4 1 0 4 4 4 0 Methyltransferase domain RskA PF10099.9 CDI80919.1 - 1.8 8.9 58.3 0.28 11.5 0.1 5.2 3 1 0 3 3 2 0 Anti-sigma-K factor rskA E7 PF00527.18 CDI80919.1 - 4.8 7.4 26.6 7.3 6.9 0.2 4.8 4 1 0 4 4 4 0 E7 protein, Early protein EPL1 PF10513.9 CDI80919.1 - 7.1 7.0 25.2 0.11 12.9 0.4 3.9 4 0 0 4 4 4 0 Enhancer of polycomb-like Ribosomal_60s PF00428.19 CDI80919.1 - 8.2 7.1 40.3 0.41 11.3 6.4 5.1 5 0 0 5 5 5 0 60s Acidic ribosomal protein RAP1 PF07218.11 CDI80933.1 - 0.052 11.8 1.8 0.063 11.6 1.8 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PAT1 PF09770.9 CDI80933.1 - 3 6.0 42.1 4.2 5.5 42.1 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Spore_II_R PF09551.10 CDI80933.1 - 6.6 7.2 13.7 0.13 12.7 3.2 2.5 2 0 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) RskA PF10099.9 CDI80933.1 - 8.4 6.6 37.2 0.74 10.1 10.9 3.0 2 1 1 3 3 3 0 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI80934.1 - 0.0021 17.2 24.3 0.0022 17.0 24.3 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Connexin PF00029.19 CDI80934.1 - 0.0052 16.6 8.9 0.0052 16.6 8.9 1.2 1 0 0 1 1 1 1 Connexin SID-1_RNA_chan PF13965.6 CDI80934.1 - 0.012 14.1 5.2 0.011 14.2 5.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2828 PF11443.8 CDI80934.1 - 0.032 12.3 13.7 0.03 12.4 13.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF819 PF05684.12 CDI80934.1 - 0.058 12.4 4.5 0.072 12.1 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF819) Presenilin PF01080.17 CDI80934.1 - 0.084 11.6 20.7 0.088 11.6 20.7 1.1 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI80934.1 - 0.11 12.4 49.4 0.13 12.2 49.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 CDI80934.1 - 0.13 11.3 14.7 0.11 11.4 14.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DDHD PF02862.17 CDI80934.1 - 0.13 12.4 17.0 0.14 12.3 17.0 1.1 1 0 0 1 1 1 0 DDHD domain Velvet PF11754.8 CDI80934.1 - 0.14 12.1 15.4 0.15 12.0 15.4 1.1 1 0 0 1 1 1 0 Velvet factor CSG2 PF16965.5 CDI80934.1 - 0.15 11.0 7.9 0.15 10.9 7.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Cons_hypoth698 PF03601.14 CDI80934.1 - 0.17 10.8 14.2 0.37 9.6 14.2 1.7 1 1 0 1 1 1 0 Conserved hypothetical protein 698 AAA_23 PF13476.6 CDI80934.1 - 0.17 12.4 18.9 0.19 12.2 18.9 1.2 1 0 0 1 1 1 0 AAA domain Serinc PF03348.15 CDI80934.1 - 0.18 10.7 11.3 0.18 10.7 11.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) FPN1 PF06963.12 CDI80934.1 - 0.27 9.7 6.9 0.34 9.4 6.9 1.2 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Folate_carrier PF01770.18 CDI80934.1 - 0.32 9.7 8.2 0.36 9.5 8.2 1.3 1 0 0 1 1 1 0 Reduced folate carrier FAM60A PF15396.6 CDI80934.1 - 0.33 10.9 11.9 0.33 10.9 11.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A FHIPEP PF00771.20 CDI80934.1 - 0.36 9.3 13.6 0.43 9.0 13.6 1.1 1 0 0 1 1 1 0 FHIPEP family TERB2 PF15101.6 CDI80934.1 - 0.37 10.8 23.9 0.43 10.6 23.9 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 V_ATPase_I PF01496.19 CDI80934.1 - 0.38 8.6 21.4 0.45 8.4 21.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PAT1 PF09770.9 CDI80934.1 - 0.41 8.8 32.2 0.43 8.8 32.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PigN PF04987.14 CDI80934.1 - 0.45 9.3 7.4 0.46 9.3 7.4 1.3 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) DUF3408 PF11888.8 CDI80934.1 - 0.49 10.5 18.1 0.75 9.9 18.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Hid1 PF12722.7 CDI80934.1 - 0.49 8.5 13.4 0.43 8.7 13.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MDM31_MDM32 PF08118.11 CDI80934.1 - 0.55 8.8 10.6 0.59 8.7 10.6 1.2 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins SpoIIP PF07454.11 CDI80934.1 - 0.59 9.5 20.9 0.75 9.2 20.9 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF2126 PF09899.9 CDI80934.1 - 0.63 8.0 10.7 0.57 8.2 10.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Paf1 PF03985.13 CDI80934.1 - 0.68 8.9 20.2 0.85 8.6 20.2 1.2 1 0 0 1 1 1 0 Paf1 Band_3_cyto PF07565.13 CDI80934.1 - 0.7 9.6 16.3 0.77 9.5 16.3 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Pap_E4 PF02711.14 CDI80934.1 - 0.84 10.6 16.0 1.2 10.1 16.0 1.2 1 0 0 1 1 1 0 E4 protein PPL5 PF18168.1 CDI80934.1 - 0.86 8.8 11.4 0.97 8.7 11.4 1.3 1 0 0 1 1 1 0 Prim-pol family 5 CobT PF06213.12 CDI80934.1 - 0.91 8.9 38.8 0.019 14.4 32.7 1.3 2 0 0 2 2 1 0 Cobalamin biosynthesis protein CobT PIP5K PF01504.18 CDI80934.1 - 0.95 8.6 16.3 1.1 8.4 16.3 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Rrn6 PF10214.9 CDI80934.1 - 1.1 7.6 21.3 0.94 7.9 21.3 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor OATP PF03137.20 CDI80934.1 - 1.2 7.4 11.6 1.7 6.8 11.6 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Mem_trans PF03547.18 CDI80934.1 - 1.6 7.0 6.5 1.7 6.9 6.5 1.2 1 0 0 1 1 1 0 Membrane transport protein Ndc1_Nup PF09531.10 CDI80934.1 - 1.7 7.2 13.1 1.6 7.3 13.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CLN3 PF02487.17 CDI80934.1 - 1.9 7.5 17.6 1.8 7.5 17.2 1.3 1 1 0 1 1 1 0 CLN3 protein DUF4395 PF14340.6 CDI80934.1 - 1.9 8.8 12.0 0.048 14.0 3.5 2.2 1 1 1 2 2 1 0 Domain of unknown function (DUF4395) DUF5327 PF17261.2 CDI80934.1 - 1.9 9.2 30.4 3.4 8.5 30.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5327) Pinin_SDK_memA PF04696.13 CDI80934.1 - 2.2 8.3 40.2 3.6 7.7 40.2 1.3 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region NEMP PF10225.9 CDI80934.1 - 2.4 7.8 9.4 2.7 7.6 9.4 1.1 1 0 0 1 1 1 0 NEMP family Activator_LAG-3 PF11498.8 CDI80934.1 - 2.5 7.0 60.7 3 6.7 60.7 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF1980 PF09323.10 CDI80934.1 - 2.8 7.8 15.1 3.6 7.5 15.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) TFB6 PF17110.5 CDI80934.1 - 3 7.6 11.7 4.8 6.9 11.7 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Nucleoside_tran PF01733.18 CDI80934.1 - 3.1 7.1 5.7 3.5 6.9 5.7 1.1 1 0 0 1 1 1 0 Nucleoside transporter Cellulose_synt PF03552.14 CDI80934.1 - 3.3 6.1 6.2 3.2 6.1 6.2 1.2 1 0 0 1 1 1 0 Cellulose synthase Baculo_PP31 PF05311.11 CDI80934.1 - 3.5 7.0 18.3 4 6.9 18.3 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) MMR1 PF08505.10 CDI80934.1 - 4.1 7.6 23.0 4.8 7.4 23.0 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Plasmodium_Vir PF05795.11 CDI80934.1 - 4.7 6.5 8.1 4 6.8 8.1 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Peptidase_S15 PF02129.18 CDI80934.1 - 5.6 6.5 19.5 7.4 6.1 19.5 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Folliculin PF11704.8 CDI80934.1 - 6 6.7 17.2 7.1 6.5 17.2 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport ALMT PF11744.8 CDI80934.1 - 6.2 5.5 17.0 6.6 5.4 17.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter HCO3_cotransp PF00955.21 CDI80934.1 - 6.3 5.5 8.0 6.3 5.5 8.0 1.1 1 0 0 1 1 1 0 HCO3- transporter family Ctr PF04145.15 CDI80934.1 - 9.1 6.9 14.9 11 6.6 14.9 1.3 1 1 0 1 1 1 0 Ctr copper transporter family NPR3 PF03666.13 CDI80944.1 - 0.0076 15.1 21.8 0.0082 15.0 21.8 1.0 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 YABBY PF04690.13 CDI80944.1 - 0.016 15.8 15.7 0.018 15.6 15.7 1.1 1 0 0 1 1 1 0 YABBY protein CobT PF06213.12 CDI80944.1 - 0.024 14.0 35.3 0.029 13.8 35.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 CDI80944.1 - 0.027 13.3 31.1 0.029 13.2 31.1 1.0 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 CDI80944.1 - 0.038 12.4 11.6 0.048 12.1 11.6 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PPL5 PF18168.1 CDI80944.1 - 0.039 13.3 17.5 0.046 13.0 17.5 1.1 1 0 0 1 1 1 0 Prim-pol family 5 V_ATPase_I PF01496.19 CDI80944.1 - 0.041 11.8 24.2 0.04 11.8 24.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DREPP PF05558.12 CDI80944.1 - 0.043 13.7 6.2 0.054 13.4 6.2 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide DUF913 PF06025.12 CDI80944.1 - 0.048 12.6 16.7 0.049 12.6 16.7 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4746 PF15928.5 CDI80944.1 - 0.052 13.0 18.2 0.052 13.0 18.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CCDC53 PF10152.9 CDI80944.1 - 0.11 12.8 26.8 0.14 12.6 26.8 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex RNA_pol_Rpc4 PF05132.14 CDI80944.1 - 0.14 12.6 19.7 0.21 12.0 19.7 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 SpoIIP PF07454.11 CDI80944.1 - 0.14 11.6 27.3 0.18 11.3 27.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Velvet PF11754.8 CDI80944.1 - 0.15 11.9 23.2 0.16 11.9 23.2 1.1 1 0 0 1 1 1 0 Velvet factor Serinc PF03348.15 CDI80944.1 - 0.16 10.9 13.9 0.19 10.6 13.9 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) CLN3 PF02487.17 CDI80944.1 - 0.21 10.6 18.4 0.23 10.5 18.4 1.2 1 0 0 1 1 1 0 CLN3 protein TRAP_alpha PF03896.16 CDI80944.1 - 0.21 10.7 13.6 0.25 10.5 13.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Afi1 PF07792.12 CDI80944.1 - 0.3 11.6 22.4 0.37 11.3 22.4 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking SLC12 PF03522.15 CDI80944.1 - 0.3 10.1 26.9 0.31 10.0 26.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Dicty_REP PF05086.12 CDI80944.1 - 0.33 8.9 20.1 0.37 8.7 20.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Endostatin PF06482.11 CDI80944.1 - 0.36 10.2 23.4 0.4 10.1 23.4 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin MAP17 PF15807.5 CDI80944.1 - 0.37 11.0 15.5 0.49 10.6 15.5 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 TFIIA PF03153.13 CDI80944.1 - 0.38 10.7 60.5 0.42 10.6 60.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit STAC2_u1 PF16664.5 CDI80944.1 - 0.43 11.0 16.2 0.58 10.6 16.2 1.3 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Band_3_cyto PF07565.13 CDI80944.1 - 0.44 10.3 22.8 0.59 9.9 22.8 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain O-antigen_lig PF13425.6 CDI80944.1 - 0.46 9.2 13.0 0.48 9.2 13.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SAPS PF04499.15 CDI80944.1 - 0.5 9.1 19.3 0.49 9.1 19.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DDHD PF02862.17 CDI80944.1 - 0.52 10.4 23.2 0.78 9.9 23.2 1.4 1 0 0 1 1 1 0 DDHD domain CSG2 PF16965.5 CDI80944.1 - 0.53 9.2 13.8 0.65 8.9 13.8 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Spore_coat_CotO PF14153.6 CDI80944.1 - 0.54 10.2 35.1 0.63 9.9 35.1 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Ureide_permease PF07168.11 CDI80944.1 - 0.57 8.9 11.8 0.87 8.3 11.8 1.4 1 0 0 1 1 1 0 Ureide permease AAA_11 PF13086.6 CDI80944.1 - 0.6 9.9 24.3 0.63 9.8 24.3 1.0 1 0 0 1 1 1 0 AAA domain PA26 PF04636.13 CDI80944.1 - 0.65 8.9 18.8 0.66 8.8 18.8 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF3295 PF11702.8 CDI80944.1 - 0.68 9.2 26.6 0.73 9.1 26.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Rtf2 PF04641.12 CDI80944.1 - 0.69 9.2 25.4 0.77 9.1 25.4 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2347 PF09804.9 CDI80944.1 - 0.69 9.4 14.3 0.72 9.4 14.3 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) PAT1 PF09770.9 CDI80944.1 - 0.74 8.0 41.3 0.76 8.0 41.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 VIR_N PF15912.5 CDI80944.1 - 0.75 9.3 16.4 0.8 9.2 16.4 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal HCO3_cotransp PF00955.21 CDI80944.1 - 0.8 8.5 11.9 0.79 8.5 11.9 1.0 1 0 0 1 1 1 0 HCO3- transporter family GAGA_bind PF06217.12 CDI80944.1 - 0.86 9.8 20.4 0.87 9.8 20.4 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family PIP5K PF01504.18 CDI80944.1 - 0.87 8.8 20.4 1.1 8.5 20.4 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Baculo_PP31 PF05311.11 CDI80944.1 - 0.89 9.0 22.6 1 8.8 22.6 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF2828 PF11443.8 CDI80944.1 - 1.1 7.3 26.6 1.2 7.2 26.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Otopetrin PF03189.13 CDI80944.1 - 1.2 7.9 14.5 1.1 7.9 14.5 1.1 1 0 0 1 1 1 0 Otopetrin CBP_BcsG PF11658.8 CDI80944.1 - 1.2 7.5 19.6 1.5 7.2 19.6 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG RR_TM4-6 PF06459.12 CDI80944.1 - 1.2 8.9 30.2 1.3 8.7 30.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2126 PF09899.9 CDI80944.1 - 1.3 7.1 20.7 1.4 6.9 20.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Neur_chan_memb PF02932.16 CDI80944.1 - 1.3 9.0 20.4 1.4 8.9 20.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MAJIN PF15077.6 CDI80944.1 - 1.4 8.7 17.4 1.4 8.6 17.4 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein NARP1 PF12569.8 CDI80944.1 - 1.5 7.6 25.5 1.8 7.4 25.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TCP PF03634.13 CDI80944.1 - 1.9 9.0 28.9 2.3 8.8 28.9 1.1 1 0 0 1 1 1 0 TCP family transcription factor Peptidase_S15 PF02129.18 CDI80944.1 - 2.4 7.7 19.0 2.9 7.4 19.0 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Zip PF02535.22 CDI80944.1 - 2.4 7.3 15.4 2.7 7.1 15.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter BORG_CEP PF14957.6 CDI80944.1 - 2.5 9.3 21.0 2.8 9.1 21.0 1.1 1 0 0 1 1 1 0 Cdc42 effector PGA2 PF07543.12 CDI80944.1 - 2.5 8.1 25.0 2.8 7.9 25.0 1.0 1 0 0 1 1 1 0 Protein trafficking PGA2 Pex14_N PF04695.13 CDI80944.1 - 3.1 8.4 41.8 4.2 8.0 41.8 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4228 PF14009.6 CDI80944.1 - 3.4 8.0 17.9 4.6 7.6 17.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Folliculin PF11704.8 CDI80944.1 - 3.9 7.3 21.5 5.3 6.9 21.5 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport eIF-3_zeta PF05091.12 CDI80944.1 - 4.5 6.1 37.4 5.2 5.9 37.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF1682 PF07946.14 CDI80944.1 - 5.2 6.2 24.6 6 6.0 24.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) PPP4R2 PF09184.11 CDI80944.1 - 5.2 6.6 21.8 6.5 6.3 21.8 1.1 1 0 0 1 1 1 0 PPP4R2 HAUS6_N PF14661.6 CDI80944.1 - 6 6.4 28.3 6.3 6.3 28.3 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus RPN2_C PF18004.1 CDI80944.1 - 6.4 6.7 29.0 8.6 6.2 29.0 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain ALMT PF11744.8 CDI80944.1 - 6.6 5.4 23.8 6.9 5.4 23.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Peroxin-3 PF04882.12 CDI80944.1 - 6.6 5.6 29.4 7.4 5.4 29.4 1.0 1 0 0 1 1 1 0 Peroxin-3 Peptidase_S49_N PF08496.10 CDI80944.1 - 6.6 6.8 28.0 13 5.8 28.0 1.5 1 1 0 1 1 1 0 Peptidase family S49 N-terminal Bac_luciferase PF00296.20 CDI80944.1 - 7.2 5.9 8.5 10 5.4 8.5 1.3 1 0 0 1 1 1 0 Luciferase-like monooxygenase Plasmodium_Vir PF05795.11 CDI80944.1 - 7.3 5.9 16.9 7.7 5.8 16.9 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Membralin PF09746.9 CDI80944.1 - 7.4 5.5 19.8 7.8 5.4 19.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein Peptidase_U57 PF05582.12 CDI80944.1 - 7.4 5.7 20.9 9.3 5.4 20.9 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Tim54 PF11711.8 CDI80944.1 - 7.8 5.2 26.4 9.3 4.9 26.4 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 MMR1 PF08505.10 CDI80944.1 - 8.4 6.6 32.4 12 6.1 32.4 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Pal1 PF08316.11 CDI80944.1 - 8.4 7.1 17.2 12 6.6 17.2 1.3 1 0 0 1 1 1 0 Pal1 cell morphology protein Cellulose_synt PF03552.14 CDI80944.1 - 8.7 4.7 14.1 10 4.5 14.1 1.0 1 0 0 1 1 1 0 Cellulose synthase Pannexin_like PF12534.8 CDI80944.1 - 8.9 5.3 21.8 9.8 5.2 21.8 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Med19 PF10278.9 CDI80944.1 - 9.7 6.1 17.9 12 5.8 17.9 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 RP-C_C PF11800.8 CDI80944.1 - 9.9 6.2 24.9 11 6.0 24.9 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region SLC12 PF03522.15 CDI80945.1 - 0.24 10.4 35.5 0.28 10.2 35.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Endostatin PF06482.11 CDI80945.1 - 0.29 10.6 34.3 0.33 10.4 34.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Presenilin PF01080.17 CDI80945.1 - 0.33 9.7 41.7 0.43 9.3 41.7 1.1 1 0 0 1 1 1 0 Presenilin HCO3_cotransp PF00955.21 CDI80945.1 - 1.2 7.9 11.3 1.4 7.7 11.3 1.3 1 0 0 1 1 1 0 HCO3- transporter family AF-4 PF05110.13 CDI80945.1 - 1.5 6.8 44.6 1.9 6.5 44.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein AAA_11 PF13086.6 CDI80945.1 - 1.8 8.3 30.8 2.2 8.0 30.8 1.1 1 0 0 1 1 1 0 AAA domain PAT1 PF09770.9 CDI80945.1 - 2.1 6.5 60.8 2.3 6.4 60.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI80945.1 - 2.1 5.3 34.1 2.4 5.1 34.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PA26 PF04636.13 CDI80945.1 - 2.3 7.1 24.5 2.7 6.8 24.5 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4551 PF15087.6 CDI80945.1 - 2.4 6.9 26.7 2.9 6.6 26.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CCSAP PF15748.5 CDI80945.1 - 2.6 8.2 42.9 3.2 7.9 42.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Neur_chan_memb PF02932.16 CDI80945.1 - 2.8 7.9 30.0 3.6 7.6 30.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LAP1C PF05609.12 CDI80945.1 - 2.8 6.9 33.1 3.4 6.7 33.1 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) MAP7 PF05672.11 CDI80945.1 - 3.2 7.4 56.1 4.8 6.9 56.1 1.3 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family Caldesmon PF02029.15 CDI80945.1 - 4.2 6.0 39.2 5 5.8 39.2 1.0 1 0 0 1 1 1 0 Caldesmon PNISR PF15996.5 CDI80945.1 - 4.6 7.5 44.1 6.2 7.1 44.1 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR CDC45 PF02724.14 CDI80945.1 - 5.1 5.3 32.6 6.3 5.0 32.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Plasmodium_Vir PF05795.11 CDI80945.1 - 5.8 6.2 19.2 9.3 5.6 19.2 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Raftlin PF15250.6 CDI80945.1 - 6.6 5.4 26.9 8.3 5.0 26.9 1.2 1 0 0 1 1 1 0 Raftlin Neuregulin PF02158.15 CDI80945.1 - 6.8 5.9 28.7 7.9 5.7 28.7 1.0 1 0 0 1 1 1 0 Neuregulin intracellular region DUF2151 PF10221.9 CDI80945.1 - 7 5.1 19.8 8.7 4.8 19.8 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator SRP-alpha_N PF04086.13 CDI80945.1 - 8.2 6.3 35.1 12 5.7 35.1 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF572 PF04502.13 CDI80945.1 - 9.6 5.7 34.4 11 5.5 34.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Smg8_Smg9 PF10220.9 CDI80945.1 - 9.9 4.3 30.1 11 4.1 30.1 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Robl_LC7 PF03259.17 CDI80949.1 - 4.3e-08 32.8 0.0 5.8e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 CDI80949.1 - 0.013 15.4 0.0 0.017 15.0 0.0 1.4 1 1 0 1 1 1 0 Ragulator complex protein LAMTOR5 Arm PF00514.23 CDI80950.1 - 2.6e-15 55.8 9.5 0.015 15.3 0.1 8.1 8 2 2 10 10 10 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 CDI80950.1 - 1.7e-06 28.3 16.2 0.0055 17.1 0.9 5.4 3 2 3 6 6 6 2 HEAT repeats HEAT PF02985.22 CDI80950.1 - 1.2e-05 25.1 3.8 24 5.6 0.0 6.6 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 CDI80950.1 - 0.0003 20.8 0.1 0.51 10.4 0.0 3.7 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 CDI80950.1 - 0.032 14.7 17.1 0.16 12.5 1.0 5.1 4 2 2 6 6 6 0 HEAT-like repeat MIP-T3_C PF17749.1 CDI80952.1 - 0.0014 18.6 0.2 0.0027 17.7 0.2 1.5 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 C-terminal region ADIP PF11559.8 CDI80952.1 - 0.0069 16.5 1.0 0.0096 16.0 1.0 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding KxDL PF10241.9 CDI80952.1 - 0.059 13.7 0.7 0.12 12.7 0.5 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein SlyX PF04102.12 CDI80952.1 - 0.066 13.8 1.2 0.12 12.9 0.3 1.9 1 1 1 2 2 2 0 SlyX Fib_alpha PF08702.10 CDI80952.1 - 0.069 13.3 0.4 0.098 12.8 0.4 1.4 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family F-box PF00646.33 CDI80955.1 - 0.0008 19.2 0.3 0.0031 17.4 0.3 2.1 1 0 0 1 1 1 1 F-box domain TSP_1 PF00090.19 CDI80958.1 - 1.9e-06 28.0 9.9 0.00058 20.0 0.8 2.8 2 0 0 2 2 2 2 Thrombospondin type 1 domain DnaJ_C PF01556.18 CDI80961.1 - 1.2e-29 103.3 0.0 4e-29 101.6 0.0 1.6 1 1 1 2 2 2 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 CDI80961.1 - 3.7e-05 24.0 14.0 8.6e-05 22.8 14.0 1.7 1 0 0 1 1 1 1 DnaJ central domain Tnp_zf-ribbon_2 PF13842.6 CDI80961.1 - 0.33 11.8 1.5 0.98 10.3 0.2 2.4 2 1 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon A_deaminase PF00962.22 CDI80962.1 - 3.1e-59 200.9 0.0 1.2e-58 199.0 0.0 1.8 1 1 0 1 1 1 1 Adenosine/AMP deaminase Meis_PKNOX_N PF16493.5 CDI80962.1 - 0.1 12.9 0.0 0.29 11.5 0.0 1.7 1 0 0 1 1 1 0 N-terminal of Homeobox Meis and PKNOX1 TFIIA PF03153.13 CDI80967.1 - 0.00019 21.5 33.7 0.00024 21.2 33.7 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI80967.1 - 0.00061 20.1 33.6 0.051 13.9 25.7 2.1 2 0 0 2 2 2 2 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI80967.1 - 0.016 14.2 7.4 0.021 13.9 7.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SUZ PF12752.7 CDI80967.1 - 0.017 15.9 1.4 0.017 15.9 1.4 2.7 2 0 0 2 2 2 0 SUZ domain RXT2_N PF08595.11 CDI80967.1 - 0.12 12.4 7.1 1.8 8.6 0.0 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal Utp14 PF04615.13 CDI80967.1 - 0.15 10.6 17.4 0.19 10.3 17.4 1.0 1 0 0 1 1 1 0 Utp14 protein DUF4667 PF15700.5 CDI80967.1 - 0.21 11.7 23.7 0.75 9.9 5.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) DUF1682 PF07946.14 CDI80967.1 - 0.53 9.5 7.1 0.66 9.1 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Connexin PF00029.19 CDI80967.1 - 0.68 9.6 5.5 0.81 9.4 3.4 1.9 2 0 0 2 2 2 0 Connexin SR-25 PF10500.9 CDI80967.1 - 0.7 9.5 30.7 0.13 11.9 2.8 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RAP1 PF07218.11 CDI80967.1 - 0.74 8.0 6.4 1.1 7.5 6.4 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Rxt3 PF08642.10 CDI80967.1 - 1.1 10.0 6.5 4.8 8.0 3.3 2.2 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 DUF1980 PF09323.10 CDI80967.1 - 1.2 9.1 9.0 7.1 6.5 6.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) CSG2 PF16965.5 CDI80967.1 - 1.2 8.0 5.6 6.4 5.6 2.6 2.0 2 0 0 2 2 2 0 Ceramide synthase regulator DUF4834 PF16118.5 CDI80967.1 - 1.5 9.8 20.4 8.6 7.4 13.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EIIBC-GUT_N PF03612.14 CDI80967.1 - 1.5 8.5 10.0 3.7 7.3 7.5 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Spt20 PF12090.8 CDI80967.1 - 1.6 8.3 36.4 1.3 8.6 32.2 2.1 2 0 0 2 2 2 0 Spt20 family TERB2 PF15101.6 CDI80967.1 - 3.4 7.7 18.1 2.7 8.0 13.3 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Renin_r PF07850.14 CDI80967.1 - 3.7 8.2 5.1 15 6.3 2.8 2.2 2 0 0 2 2 2 0 Renin receptor-like protein Roughex PF06020.11 CDI80967.1 - 4.2 6.4 11.6 7.2 5.6 11.6 1.4 1 0 0 1 1 1 0 Drosophila roughex protein FAM176 PF14851.6 CDI80967.1 - 4.6 6.9 10.8 25 4.5 0.1 2.1 2 0 0 2 2 2 0 FAM176 family RR_TM4-6 PF06459.12 CDI80967.1 - 4.8 6.9 19.3 6.3 6.5 18.6 1.4 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 Med15 PF09606.10 CDI80967.1 - 5.4 5.6 32.8 6.5 5.3 32.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Coilin_N PF15862.5 CDI80967.1 - 6 6.7 21.6 8.9 6.1 13.3 2.2 2 0 0 2 2 2 0 Coilin N-terminus Pap_E4 PF02711.14 CDI80967.1 - 6.3 7.8 16.9 12 6.9 1.7 2.4 2 0 0 2 2 2 0 E4 protein PAT1 PF09770.9 CDI80967.1 - 8.3 4.5 23.2 10 4.2 23.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hamartin PF04388.12 CDI80967.1 - 8.3 4.9 18.5 11 4.6 18.5 1.1 1 0 0 1 1 1 0 Hamartin protein EPL1 PF10513.9 CDI80967.1 - 8.5 6.7 16.5 20 5.5 0.1 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF5427 PF10310.9 CDI80967.1 - 9.4 5.1 21.7 1.1 8.1 11.9 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5427) SLC3A2_N PF16028.5 CDI80969.1 - 0.19 11.3 0.1 0.5 10.0 0.1 1.7 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus Alg14 PF08660.11 CDI80969.1 - 7.9 6.4 9.6 14 5.5 9.6 1.6 1 1 0 1 1 1 0 Oligosaccharide biosynthesis protein Alg14 like Macoilin PF09726.9 CDI80972.1 - 0.0024 16.5 53.4 0.0024 16.5 53.4 2.5 2 1 1 3 3 3 1 Macoilin family DUF4207 PF13904.6 CDI80972.1 - 0.0038 17.0 23.7 0.0038 17.0 23.7 4.9 3 1 0 3 3 3 1 Domain of unknown function (DUF4207) SR-25 PF10500.9 CDI80972.1 - 0.0058 16.3 27.2 0.0058 16.3 27.2 5.1 3 3 2 5 5 5 1 Nuclear RNA-splicing-associated protein Peptidase_S49_N PF08496.10 CDI80975.1 - 0.0058 16.7 18.1 0.0058 16.7 18.1 3.5 1 1 2 3 3 3 1 Peptidase family S49 N-terminal Phage_holin_3_6 PF07332.11 CDI80975.1 - 0.064 13.3 9.5 0.11 12.6 9.5 1.4 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III TFIIA PF03153.13 CDI80980.1 - 0.0097 15.9 17.9 0.0098 15.9 17.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Forkhead_N PF08430.12 CDI80980.1 - 0.063 13.9 3.3 0.077 13.6 3.3 1.1 1 0 0 1 1 1 0 Forkhead N-terminal region SprA-related PF12118.8 CDI80980.1 - 0.21 10.7 21.0 0.25 10.4 21.0 1.1 1 0 0 1 1 1 0 SprA-related family PepSY_2 PF13670.6 CDI80980.1 - 3 7.9 13.3 4.7 7.3 13.3 1.3 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain RskA PF10099.9 CDI80980.1 - 4.3 7.6 22.2 7.7 6.8 22.2 1.5 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Dopey_N PF04118.14 CDI80984.1 - 0.014 14.6 2.2 0.014 14.6 2.2 2.6 2 1 0 2 2 2 0 Dopey, N-terminal CDC27 PF09507.10 CDI80984.1 - 1.7 7.9 40.7 2.5 7.4 40.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Cgr1 PF03879.14 CDI80984.1 - 4.9 7.6 36.6 0.41 11.0 20.2 2.3 2 0 0 2 2 2 0 Cgr1 family ERCC4 PF02732.15 CDI81008.1 - 1.1e-12 48.4 0.0 1.1e-12 48.4 0.0 4.3 3 1 0 3 3 3 1 ERCC4 domain SUIM_assoc PF16619.5 CDI81008.1 - 0.00094 19.2 0.9 0.00094 19.2 0.9 8.4 7 3 0 7 7 7 1 Unstructured region C-term to UIM in Ataxin3 DUF1980 PF09323.10 CDI81008.1 - 0.068 13.1 0.1 0.068 13.1 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Sin_N PF04801.13 CDI81008.1 - 5.6 6.1 46.8 0.056 12.7 21.3 2.9 3 0 0 3 3 3 0 Sin-like protein conserved region Zip PF02535.22 CDI81008.1 - 5.7 6.0 9.7 0.086 12.1 0.9 2.3 3 0 0 3 3 3 0 ZIP Zinc transporter DUF4763 PF15960.5 CDI81012.1 - 0.00058 19.2 8.7 0.00058 19.2 8.7 3.1 2 1 1 3 3 3 1 Domain of unknown function (DUF4763) Draxin PF15550.6 CDI81012.1 - 0.15 11.9 7.5 2.2 8.1 2.3 2.1 2 0 0 2 2 2 0 Draxin FAP PF07174.11 CDI81012.1 - 0.17 11.3 22.8 0.33 10.4 22.8 1.4 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) RskA PF10099.9 CDI81012.1 - 0.83 9.9 51.0 0.097 13.0 20.3 3.2 1 1 2 3 3 3 0 Anti-sigma-K factor rskA TCP PF03634.13 CDI81012.1 - 7.1 7.2 17.8 9.9 6.7 8.9 2.2 2 0 0 2 2 2 0 TCP family transcription factor Spt20 PF12090.8 CDI81016.1 - 0.002 17.8 4.9 0.002 17.8 4.9 5.5 3 2 0 3 3 1 1 Spt20 family Pox_Ag35 PF03286.14 CDI81016.1 - 0.0032 17.3 16.0 0.0032 17.3 16.0 2.9 3 0 0 3 3 3 1 Pox virus Ag35 surface protein RskA PF10099.9 CDI81016.1 - 0.0035 17.7 0.2 0.0035 17.7 0.2 6.3 2 2 1 3 3 1 1 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI81016.1 - 0.0037 17.3 5.3 0.0037 17.3 5.3 8.8 5 2 1 6 6 4 1 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 CDI81016.1 - 0.0042 16.1 1.2 0.0042 16.1 1.2 6.2 4 1 2 6 6 3 1 Protein of unknown function (DUF2722) Isy1 PF06246.12 CDI81016.1 - 0.049 13.2 35.8 1.3 8.5 2.9 3.4 3 0 0 3 3 3 0 Isy1-like splicing family RR_TM4-6 PF06459.12 CDI81016.1 - 0.16 11.8 46.9 0.022 14.6 25.2 3.3 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 Lin-8 PF03353.15 CDI81016.1 - 0.19 11.2 53.4 0.39 10.2 32.1 3.2 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist DUF4079 PF13301.6 CDI81016.1 - 0.54 10.4 0.0 0.54 10.4 0.0 3.7 2 2 0 2 2 1 0 Protein of unknown function (DUF4079) SRP-alpha_N PF04086.13 CDI81016.1 - 2.2 8.1 44.3 2.6 7.9 25.4 3.3 3 0 0 3 3 3 0 Signal recognition particle, alpha subunit, N-terminal DUF4551 PF15087.6 CDI81016.1 - 5.2 5.8 43.9 4.1 6.1 26.8 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4551) Endostatin PF06482.11 CDI81016.1 - 8.1 5.8 49.6 5 6.5 31.3 3.2 3 0 0 3 3 3 0 Collagenase NC10 and Endostatin Presenilin PF01080.17 CDI81021.1 - 0.0002 20.2 38.9 0.00024 20.0 38.9 1.2 1 0 0 1 1 1 1 Presenilin DUF853 PF05872.12 CDI81021.1 - 0.0011 17.6 22.1 0.0018 17.0 22.1 1.3 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF853) PNISR PF15996.5 CDI81021.1 - 0.0033 17.7 39.2 0.0048 17.2 39.2 1.4 1 0 0 1 1 1 1 Arginine/serine-rich protein PNISR SAGA-Tad1 PF12767.7 CDI81021.1 - 0.013 15.3 28.2 0.016 15.0 28.2 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit PAT1 PF09770.9 CDI81021.1 - 0.021 13.1 53.5 0.023 13.0 53.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Exonuc_VII_L PF02601.15 CDI81021.1 - 0.025 14.2 30.5 0.027 14.1 30.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CCSAP PF15748.5 CDI81021.1 - 0.047 13.9 44.1 0.066 13.4 44.1 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CDC45 PF02724.14 CDI81021.1 - 0.11 10.8 34.7 0.14 10.4 34.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Sin_N PF04801.13 CDI81021.1 - 0.12 11.6 49.4 0.14 11.4 49.4 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region DUF966 PF06136.13 CDI81021.1 - 0.12 12.1 32.7 0.15 11.8 32.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF4045 PF13254.6 CDI81021.1 - 0.13 11.9 32.4 0.17 11.5 32.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) MDM10 PF12519.8 CDI81021.1 - 0.17 10.7 28.1 0.23 10.3 28.1 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Raftlin PF15250.6 CDI81021.1 - 0.21 10.3 28.1 0.26 10.0 28.1 1.3 1 0 0 1 1 1 0 Raftlin ALMT PF11744.8 CDI81021.1 - 0.35 9.6 27.9 0.46 9.2 27.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter XRN_M PF17846.1 CDI81021.1 - 0.51 9.2 28.5 0.6 9.0 28.5 1.1 1 0 0 1 1 1 0 Xrn1 helical domain SLC12 PF03522.15 CDI81021.1 - 0.68 8.9 40.6 0.94 8.4 40.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 GAGA_bind PF06217.12 CDI81021.1 - 0.77 10.0 29.6 0.95 9.7 29.6 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family LAP1C PF05609.12 CDI81021.1 - 0.96 8.5 38.7 1.1 8.2 38.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) BAF1_ABF1 PF04684.13 CDI81021.1 - 1 8.4 36.4 1.3 8.0 36.4 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor NPR3 PF03666.13 CDI81021.1 - 1 8.1 35.9 1.3 7.7 35.9 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 LicD PF04991.13 CDI81021.1 - 1.1 9.3 13.0 1.5 8.9 13.0 1.3 1 0 0 1 1 1 0 LicD family Hamartin PF04388.12 CDI81021.1 - 1.2 7.8 34.7 1.5 7.4 34.7 1.2 1 0 0 1 1 1 0 Hamartin protein AAA_11 PF13086.6 CDI81021.1 - 1.2 8.9 35.3 1.7 8.4 35.3 1.3 1 0 0 1 1 1 0 AAA domain MCM_bind PF09739.9 CDI81021.1 - 1.4 7.2 32.3 2 6.7 32.3 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor SOBP PF15279.6 CDI81021.1 - 2.4 8.7 34.8 3.1 8.3 34.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Asp-B-Hydro_N PF05279.11 CDI81021.1 - 2.8 7.9 33.6 3.6 7.6 33.6 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region GREB1 PF15782.5 CDI81021.1 - 3.1 4.8 40.0 3.4 4.6 40.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Membralin PF09746.9 CDI81021.1 - 3.1 6.8 25.0 4.4 6.3 25.0 1.4 1 0 0 1 1 1 0 Tumour-associated protein CAC1F_C PF16885.5 CDI81021.1 - 3.4 7.2 28.0 5 6.7 28.0 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term DUF4407 PF14362.6 CDI81021.1 - 4.2 6.6 43.6 6.9 5.9 43.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2151 PF10221.9 CDI81021.1 - 7.4 5.0 24.5 8.8 4.8 24.5 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator TP53IP5 PF15331.6 CDI81021.1 - 8.6 6.4 28.4 11 6.1 28.4 1.3 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 DUF4770 PF15994.5 CDI81028.1 - 8.1 6.6 40.8 1.6 9.0 11.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Ntox10 PF15520.6 CDI81036.1 - 5.5 6.8 9.5 1.5 8.7 6.1 1.7 2 0 0 2 2 2 0 Novel toxin 10 DUF2722 PF10846.8 CDI81038.1 - 8.2e-06 25.0 21.1 2.3e-05 23.6 13.5 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) LMBR1 PF04791.16 CDI81038.1 - 0.46 9.3 1.3 0.82 8.5 1.3 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein EOS1 PF12326.8 CDI81038.1 - 0.47 10.4 7.9 9.7 6.1 3.1 3.0 2 1 0 2 2 2 0 N-glycosylation protein FHIPEP PF00771.20 CDI81038.1 - 1.4 7.2 12.6 1.4 7.3 1.5 2.3 2 0 0 2 2 2 0 FHIPEP family Spt20 PF12090.8 CDI81038.1 - 2.1 7.9 46.6 0.43 10.2 0.6 2.5 3 0 0 3 3 3 0 Spt20 family DUF4770 PF15994.5 CDI81038.1 - 3 8.1 12.5 1.3 9.3 7.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Glyco_hydro_52 PF03512.13 CDI81038.1 - 3 6.7 7.1 8.4 5.2 6.2 1.8 1 1 1 2 2 2 0 Glycosyl hydrolase family 52 Formyl_trans_N PF00551.19 CDI81038.1 - 4.8 6.9 13.5 0.054 13.2 1.2 2.6 2 0 0 2 2 2 0 Formyl transferase DUF4834 PF16118.5 CDI81038.1 - 5.6 8.0 20.1 15 6.6 13.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CLN3 PF02487.17 CDI81038.1 - 8.4 5.3 6.9 7.9 5.4 4.6 2.0 2 0 0 2 2 2 0 CLN3 protein PRC2_HTH_1 PF18118.1 CDI81038.1 - 9.1 7.2 9.9 1.5 9.7 2.8 2.8 3 0 0 3 3 3 0 Polycomb repressive complex 2 tri-helical domain Utp14 PF04615.13 CDI81039.1 - 0.59 8.6 39.5 0.76 8.3 39.5 1.0 1 0 0 1 1 1 0 Utp14 protein TMEM51 PF15345.6 CDI81045.1 - 0.0012 18.7 4.0 0.0019 18.1 4.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 51 Baculo_PP31 PF05311.11 CDI81045.1 - 0.003 17.1 1.0 0.004 16.7 1.0 1.1 1 0 0 1 1 1 1 Baculovirus 33KDa late protein (PP31) TCP PF03634.13 CDI81045.1 - 0.0079 16.8 8.2 0.014 16.0 8.2 1.3 1 0 0 1 1 1 1 TCP family transcription factor Spt20 PF12090.8 CDI81045.1 - 0.016 14.8 14.3 0.023 14.3 14.3 1.3 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI81045.1 - 0.02 14.9 16.2 0.023 14.7 16.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Beta-lactamase PF00144.24 CDI81045.1 - 0.026 13.7 0.1 0.044 13.0 0.1 1.3 1 0 0 1 1 1 0 Beta-lactamase DUF4692 PF15763.5 CDI81045.1 - 0.029 14.8 10.6 0.22 12.0 1.8 2.2 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) EPL1 PF10513.9 CDI81045.1 - 0.097 13.1 4.5 0.14 12.6 4.5 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Presenilin PF01080.17 CDI81045.1 - 0.62 8.8 4.8 0.81 8.4 4.8 1.1 1 0 0 1 1 1 0 Presenilin FHIPEP PF00771.20 CDI81047.1 - 0.00028 19.5 18.1 0.0082 14.7 13.2 2.1 2 0 0 2 2 2 2 FHIPEP family RskA PF10099.9 CDI81047.1 - 0.0021 18.4 4.1 0.0021 18.4 4.1 3.4 1 1 1 3 3 2 1 Anti-sigma-K factor rskA ZapB PF06005.12 CDI81047.1 - 0.007 16.8 1.8 0.007 16.8 1.8 3.3 3 0 0 3 3 2 1 Cell division protein ZapB Presenilin PF01080.17 CDI81047.1 - 0.071 11.9 33.2 0.022 13.5 20.1 2.1 2 0 0 2 2 2 0 Presenilin PA26 PF04636.13 CDI81047.1 - 0.095 11.6 19.4 0.011 14.7 12.1 2.0 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) WD40 PF00400.32 CDI81047.1 - 0.14 13.1 0.0 1.2 10.1 0.0 2.4 2 0 0 2 2 2 0 WD domain, G-beta repeat Rgp1 PF08737.10 CDI81047.1 - 0.17 11.0 25.7 0.6 9.2 15.5 2.1 2 0 0 2 2 2 0 Rgp1 N6_N4_Mtase PF01555.18 CDI81047.1 - 0.35 10.5 3.2 0.98 9.1 3.4 1.6 1 1 0 1 1 1 0 DNA methylase Mem_trans PF03547.18 CDI81047.1 - 0.39 9.1 8.2 0.18 10.2 1.7 2.1 2 0 0 2 2 2 0 Membrane transport protein DUF2828 PF11443.8 CDI81047.1 - 0.54 8.3 22.1 0.71 7.9 16.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) ALMT PF11744.8 CDI81047.1 - 0.57 8.9 25.4 0.058 12.2 16.0 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter CLN3 PF02487.17 CDI81047.1 - 0.81 8.7 18.3 0.16 11.0 11.2 2.2 2 0 0 2 2 2 0 CLN3 protein Metal_hydrol PF10118.9 CDI81047.1 - 1.1 8.9 8.0 1.9 8.2 8.0 1.3 1 0 0 1 1 1 0 Predicted metal-dependent hydrolase Glyco_transf_18 PF15024.6 CDI81047.1 - 1.2 7.6 17.5 0.17 10.5 13.5 1.5 2 0 0 2 2 2 0 Glycosyltransferase family 18 Rtf2 PF04641.12 CDI81047.1 - 1.4 8.2 30.5 2.4 7.5 1.5 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger FAM60A PF15396.6 CDI81047.1 - 1.9 8.5 28.6 1.2 9.1 1.0 2.2 2 0 0 2 2 2 0 Protein Family FAM60A DUF4604 PF15377.6 CDI81047.1 - 2.3 8.6 29.3 3.1 8.2 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) CENP-O PF09496.10 CDI81047.1 - 2.4 8.1 24.0 0.97 9.4 18.6 2.5 2 0 0 2 2 2 0 Cenp-O kinetochore centromere component MDM10 PF12519.8 CDI81047.1 - 3.6 6.3 21.3 0.63 8.8 14.4 2.1 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 DRY_EERY PF09750.9 CDI81047.1 - 4.9 7.4 28.5 0.35 11.1 0.5 2.2 2 0 0 2 2 2 0 Alternative splicing regulator CBP_BcsG PF11658.8 CDI81047.1 - 5.1 5.4 20.7 1.7 7.0 14.1 2.4 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG Cellulose_synt PF03552.14 CDI81047.1 - 5.9 5.2 5.3 10 4.4 5.3 1.5 1 0 0 1 1 1 0 Cellulose synthase Neur_chan_memb PF02932.16 CDI81047.1 - 7.2 6.6 26.5 4.4 7.3 1.1 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF5427 PF10310.9 CDI81047.1 - 8.8 5.2 34.2 3 6.7 22.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5427) DUF4776 PF16003.5 CDI81047.1 - 9.1 5.2 32.8 6.9 5.6 24.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) K_channel_TID PF07941.11 CDI81050.1 - 0.001 19.5 10.1 0.001 19.5 10.1 5.1 5 1 0 5 5 5 1 Potassium channel Kv1.4 tandem inactivation domain DUF4551 PF15087.6 CDI81058.1 - 1.9 7.2 40.0 2.2 7.0 40.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RSB_motif PF16294.5 CDI81058.1 - 9 6.6 40.6 4.9 7.5 15.9 2.2 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif PBP1_TM PF14812.6 CDI81058.1 - 9.3 6.7 23.2 11 6.4 7.4 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Afi1 PF07792.12 CDI81068.1 - 0.11 13.0 21.6 0.12 12.8 21.6 1.0 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Vfa1 PF08432.10 CDI81068.1 - 0.11 12.8 24.7 0.13 12.6 24.7 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SnAPC_2_like PF11035.8 CDI81068.1 - 0.14 12.2 16.8 0.16 12.1 16.8 1.0 1 0 0 1 1 1 0 Small nuclear RNA activating complex subunit 2, SNAP190 Myb Connexin PF00029.19 CDI81068.1 - 0.19 11.5 18.3 0.2 11.4 18.3 1.1 1 0 0 1 1 1 0 Connexin ATP11 PF06644.11 CDI81068.1 - 0.26 11.1 23.7 0.29 10.9 23.7 1.0 1 0 0 1 1 1 0 ATP11 protein Pinin_SDK_memA PF04696.13 CDI81068.1 - 0.59 10.2 40.4 0.73 9.9 40.4 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region TRAP_alpha PF03896.16 CDI81068.1 - 0.81 8.8 16.1 0.9 8.7 16.1 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CCDC53 PF10152.9 CDI81068.1 - 0.83 10.1 25.7 0.95 9.9 25.7 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Sec62 PF03839.16 CDI81068.1 - 0.95 8.9 20.2 1 8.8 20.2 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 DUF913 PF06025.12 CDI81068.1 - 1.1 8.2 17.5 1 8.2 17.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2072 PF09845.9 CDI81068.1 - 1.2 9.4 18.5 1.4 9.2 18.5 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein DUF3807 PF12720.7 CDI81068.1 - 1.4 9.2 32.7 1.5 9.0 32.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF1764 PF08576.10 CDI81068.1 - 1.5 9.8 19.6 2.3 9.1 19.6 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF2464 PF10240.9 CDI81068.1 - 1.7 8.2 17.8 1.9 8.0 17.8 1.0 1 0 0 1 1 1 0 Multivesicular body subunit 12 DUF4746 PF15928.5 CDI81068.1 - 1.7 8.0 24.9 1.8 7.9 24.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) YABBY PF04690.13 CDI81068.1 - 1.8 9.1 20.9 1.8 9.1 20.9 1.0 1 0 0 1 1 1 0 YABBY protein PPL5 PF18168.1 CDI81068.1 - 2 7.6 20.3 2.2 7.5 20.3 1.0 1 0 0 1 1 1 0 Prim-pol family 5 DDHD PF02862.17 CDI81068.1 - 2.1 8.5 21.1 2.7 8.1 21.1 1.2 1 0 0 1 1 1 0 DDHD domain CLN3 PF02487.17 CDI81068.1 - 2.1 7.3 19.6 2 7.4 19.6 1.0 1 0 0 1 1 1 0 CLN3 protein CPSF100_C PF13299.6 CDI81068.1 - 2.1 8.5 20.7 3.2 7.9 20.7 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2151 PF10221.9 CDI81068.1 - 2.4 6.7 15.8 2.5 6.6 15.8 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator CobT PF06213.12 CDI81068.1 - 2.5 7.4 40.8 2.8 7.2 40.8 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RPN2_C PF18004.1 CDI81068.1 - 2.6 8.0 24.1 3.2 7.6 24.1 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain RNA_pol_Rpc4 PF05132.14 CDI81068.1 - 2.8 8.4 21.8 3.3 8.1 21.8 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF4637 PF15470.6 CDI81068.1 - 2.8 7.7 17.9 3.8 7.2 17.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) BORG_CEP PF14957.6 CDI81068.1 - 2.8 9.1 18.1 2.9 9.1 18.1 1.0 1 0 0 1 1 1 0 Cdc42 effector MMU163 PF17119.5 CDI81068.1 - 2.9 7.0 13.5 3.4 6.7 13.5 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Presenilin PF01080.17 CDI81068.1 - 3 6.5 31.4 3.1 6.5 31.4 1.0 1 0 0 1 1 1 0 Presenilin RP-C_C PF11800.8 CDI81068.1 - 3.1 7.8 21.4 3.1 7.8 21.4 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region SpoIIP PF07454.11 CDI81068.1 - 3.3 7.1 30.4 3.8 6.9 30.4 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) V_ATPase_I PF01496.19 CDI81068.1 - 3.6 5.4 29.1 3.9 5.3 29.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NOA36 PF06524.12 CDI81068.1 - 3.6 6.8 15.9 4 6.7 15.9 1.0 1 0 0 1 1 1 0 NOA36 protein RR_TM4-6 PF06459.12 CDI81068.1 - 4.1 7.2 28.8 4.6 7.0 28.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.8 CDI81068.1 - 4.2 6.1 25.6 4.8 5.9 25.6 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Gti1_Pac2 PF09729.9 CDI81068.1 - 4.6 7.3 20.7 5.2 7.1 20.7 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family FAM60A PF15396.6 CDI81068.1 - 5 7.1 20.4 5.8 6.8 20.4 1.0 1 0 0 1 1 1 0 Protein Family FAM60A MCM_bind PF09739.9 CDI81068.1 - 5.1 5.4 21.9 5.1 5.4 21.9 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor PBP1_TM PF14812.6 CDI81068.1 - 5.3 7.5 12.8 7.7 7.0 12.8 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC45 PF02724.14 CDI81068.1 - 5.6 5.1 24.2 6 5.0 24.2 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4446 PF14584.6 CDI81068.1 - 5.9 6.9 15.2 8.5 6.3 15.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF4045 PF13254.6 CDI81068.1 - 5.9 6.4 22.4 6.7 6.2 22.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Peptidase_S49_N PF08496.10 CDI81068.1 - 6.1 6.9 22.3 9.4 6.3 22.3 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal NPR3 PF03666.13 CDI81068.1 - 6.5 5.4 24.2 7.4 5.2 24.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Scs3p PF10261.9 CDI81068.1 - 6.6 6.2 10.0 7.3 6.0 10.0 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF3306 PF11748.8 CDI81068.1 - 6.8 7.6 23.2 9.7 7.1 23.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Paf1 PF03985.13 CDI81068.1 - 7.3 5.5 36.5 8.1 5.3 36.5 1.0 1 0 0 1 1 1 0 Paf1 Rtf2 PF04641.12 CDI81068.1 - 7.5 5.8 25.2 8.6 5.6 25.2 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2052 PF09747.9 CDI81068.1 - 7.7 6.6 30.6 8.5 6.5 30.6 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Paramyxo_ncap PF00973.19 CDI81068.1 - 7.8 5.3 19.3 7.9 5.3 19.3 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein SelP_N PF04592.14 CDI81068.1 - 8 5.8 21.1 9.2 5.6 21.1 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CSG2 PF16965.5 CDI81068.1 - 8.3 5.2 15.9 8.5 5.2 15.9 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator CSRNP_N PF16019.5 CDI81068.1 - 8.7 6.2 23.5 9.8 6.0 23.5 1.0 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus NARP1 PF12569.8 CDI81068.1 - 8.8 5.1 24.3 10 4.9 24.3 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF2828 PF11443.8 CDI81068.1 - 8.8 4.3 24.3 9.1 4.2 24.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Ctr PF04145.15 CDI81068.1 - 9.6 6.8 14.0 12 6.5 14.0 1.2 1 0 0 1 1 1 0 Ctr copper transporter family ADP_ribosyl_GH PF03747.14 CDI81070.1 - 0.0031 17.3 4.1 0.0031 17.3 4.1 1.5 2 0 0 2 2 2 1 ADP-ribosylglycohydrolase Prominin PF05478.11 CDI81071.1 - 9.5 4.0 10.3 11 3.8 10.3 1.2 1 0 0 1 1 1 0 Prominin ANAPC4_WD40 PF12894.7 CDI81072.1 - 4e-10 39.9 0.0 3.8e-06 27.1 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDI81072.1 - 5.5e-10 39.7 3.8 0.31 12.0 0.0 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat TFIIA PF03153.13 CDI81072.1 - 0.0087 16.1 14.8 0.0087 16.1 14.8 2.7 3 0 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit BBS2_Mid PF14783.6 CDI81072.1 - 0.055 13.5 0.0 15 5.7 0.0 2.4 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Ge1_WD40 PF16529.5 CDI81072.1 - 0.11 11.5 0.0 10 5.0 0.0 2.7 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein His_Phos_1 PF00300.22 CDI81079.1 - 9.8e-06 25.4 11.0 0.13 11.9 0.0 3.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Nitroreductase PF00881.24 CDI81079.1 - 0.00069 19.7 4.9 0.00087 19.4 4.9 1.1 1 0 0 1 1 1 1 Nitroreductase family TFIIA PF03153.13 CDI81079.1 - 0.0092 16.0 10.9 0.011 15.8 10.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI81079.1 - 0.017 14.7 11.5 0.019 14.6 11.5 1.1 1 0 0 1 1 1 0 Spt20 family Activator_LAG-3 PF11498.8 CDI81079.1 - 0.02 13.9 14.4 0.026 13.5 14.4 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF2722 PF10846.8 CDI81079.1 - 0.023 13.6 6.9 0.023 13.6 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DAZAP2 PF11029.8 CDI81079.1 - 0.065 14.2 13.6 0.1 13.5 13.6 1.3 1 0 0 1 1 1 0 DAZ associated protein 2 (DAZAP2) DUF4364 PF14277.6 CDI81079.1 - 0.07 12.9 0.2 0.13 12.0 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4364) Pex14_N PF04695.13 CDI81079.1 - 0.12 13.0 10.1 0.17 12.6 10.1 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3995 PF13160.6 CDI81079.1 - 0.16 12.3 6.8 0.26 11.7 6.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3995) Tic110 PF16940.5 CDI81079.1 - 0.5 8.8 4.8 0.52 8.7 4.8 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter Ndc1_Nup PF09531.10 CDI81079.1 - 0.95 8.1 5.8 1 8.0 5.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SAP130_C PF16014.5 CDI81079.1 - 1.3 8.1 10.8 1.5 7.9 10.8 1.0 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus SR-25 PF10500.9 CDI81080.1 - 4.1e-05 23.3 20.4 4.1e-05 23.3 20.4 3.5 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein CSG2 PF16965.5 CDI81080.1 - 0.00047 19.2 8.6 0.00047 19.2 8.6 2.9 2 1 1 3 3 3 1 Ceramide synthase regulator UPF0564 PF10595.9 CDI81080.1 - 0.0028 16.8 45.6 0.018 14.1 12.9 2.2 2 0 0 2 2 2 2 Uncharacterised protein family UPF0564 RskA PF10099.9 CDI81080.1 - 0.021 15.1 47.9 0.17 12.2 0.0 4.0 1 1 0 2 2 2 0 Anti-sigma-K factor rskA Utp14 PF04615.13 CDI81080.1 - 0.031 12.9 50.8 0.041 12.5 50.8 1.0 1 0 0 1 1 1 0 Utp14 protein AAA_23 PF13476.6 CDI81080.1 - 0.49 10.9 45.3 0.06 13.8 9.9 2.3 2 0 0 2 2 2 0 AAA domain SARAF PF06682.12 CDI81080.1 - 2.9 7.4 35.8 0.052 13.2 11.9 2.7 2 1 1 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis Peptidase_S49_N PF08496.10 CDI81085.1 - 0.42 10.7 3.3 1.6 8.7 3.3 2.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF1072 PF06380.11 CDI81085.1 - 0.77 9.7 5.8 3.5 7.6 5.8 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1072) SART-1 PF03343.13 CDI81085.1 - 2.2 6.8 12.1 4.7 5.6 12.1 1.5 1 0 0 1 1 1 0 SART-1 family TFIIA PF03153.13 CDI81085.1 - 2.5 8.0 57.4 3.1 7.7 37.3 3.5 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit CCDC53 PF10152.9 CDI81085.1 - 3.5 8.0 0.0 3.5 8.0 0.0 5.1 3 1 0 4 4 4 0 Subunit CCDC53 of WASH complex CTP_transf_like PF01467.26 CDI81089.1 - 0.004 17.4 0.0 0.004 17.4 0.0 2.4 2 2 0 2 2 2 1 Cytidylyltransferase-like RR_TM4-6 PF06459.12 CDI81089.1 - 0.78 9.5 56.9 0.56 10.0 33.1 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 MAM33 PF02330.16 CDI81090.1 - 6.3 6.7 26.5 41 4.0 26.3 1.8 1 1 0 1 1 1 0 Mitochondrial glycoprotein DUF3439 PF11921.8 CDI81091.1 - 0.0037 17.2 7.6 0.0054 16.7 7.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) SSP160 PF06933.11 CDI81091.1 - 0.0085 14.4 16.1 0.0097 14.2 16.1 1.0 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 Sporozoite_P67 PF05642.11 CDI81091.1 - 0.012 13.8 4.2 0.014 13.6 4.2 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PGA2 PF07543.12 CDI81091.1 - 0.13 12.2 9.6 0.18 11.8 9.6 1.1 1 0 0 1 1 1 0 Protein trafficking PGA2 Menin PF05053.13 CDI81091.1 - 0.26 9.6 14.3 0.3 9.4 14.3 1.0 1 0 0 1 1 1 0 Menin FSA_C PF10479.9 CDI81091.1 - 0.27 9.3 6.6 0.32 9.1 6.6 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PRR18 PF15671.5 CDI81091.1 - 0.32 10.8 10.3 0.36 10.7 10.3 1.2 1 0 0 1 1 1 0 Proline-rich protein family 18 Herpes_UL74 PF07982.12 CDI81091.1 - 0.38 9.7 8.6 0.44 9.5 8.6 1.2 1 0 0 1 1 1 0 Herpes UL74 glycoproteins ASD2 PF08687.11 CDI81091.1 - 0.92 9.0 15.4 1.3 8.5 15.4 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 SpoIIIAH PF12685.7 CDI81091.1 - 2.4 7.9 19.6 2.9 7.6 19.6 1.0 1 0 0 1 1 1 0 SpoIIIAH-like protein MSP1_C PF07462.11 CDI81091.1 - 2.9 6.5 10.4 3.2 6.3 10.4 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Gti1_Pac2 PF09729.9 CDI81091.1 - 5.2 7.1 10.8 11 6.1 10.8 1.5 1 1 0 1 1 1 0 Gti1/Pac2 family DUF3295 PF11702.8 CDI81091.1 - 5.7 6.2 19.0 6.8 5.9 19.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Dehydratase_MU PF02288.15 CDI81091.1 - 6.4 6.7 10.0 0.4 10.6 4.6 1.7 2 0 0 2 2 2 0 Dehydratase medium subunit TFIIA PF03153.13 CDI81094.1 - 0.0027 17.8 32.6 0.004 17.2 32.6 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI81094.1 - 0.094 12.3 49.4 0.36 10.4 9.5 3.1 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein Ferlin_C PF16165.5 CDI81094.1 - 3.3 7.6 7.1 2.9 7.8 0.5 2.4 2 0 0 2 2 2 0 Ferlin C-terminus Patched PF02460.18 CDI81095.1 - 8e-99 331.8 1.3 2.7e-80 270.6 0.0 3.0 2 1 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 CDI81095.1 - 1.2e-29 103.1 6.9 1.2e-29 103.1 6.9 2.6 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation IZUMO PF15005.6 CDI81095.1 - 0.25 11.8 2.3 0.3 11.6 0.2 2.1 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated ACR_tran PF00873.19 CDI81095.1 - 2.7 5.5 9.4 4.2 4.9 9.4 1.2 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family MORN PF02493.20 CDI81096.1 - 1.9e-31 106.1 41.3 2.4e-06 27.1 1.4 8.1 8 0 0 8 8 8 6 MORN repeat CRAL_TRIO PF00650.20 CDI81097.1 - 0.0017 18.1 0.1 0.0043 16.8 0.1 1.6 1 1 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 CDI81097.1 - 0.0046 17.1 0.2 0.0073 16.5 0.2 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Ribosomal_60s PF00428.19 CDI81097.1 - 0.028 15.0 7.3 0.074 13.6 7.3 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Ribosomal_60s PF00428.19 CDI81100.1 - 0.37 11.4 14.8 0.8 10.3 14.8 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein DNA_pol_phi PF04931.13 CDI81103.1 - 0.016 13.4 16.4 0.02 13.0 16.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Rtf2 PF04641.12 CDI81103.1 - 0.14 11.5 21.4 0.17 11.3 21.4 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Gti1_Pac2 PF09729.9 CDI81103.1 - 0.16 12.0 17.5 0.19 11.8 17.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Pox_Ag35 PF03286.14 CDI81103.1 - 0.17 11.7 11.3 0.18 11.5 11.3 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Slu7 PF11708.8 CDI81103.1 - 0.19 11.4 19.3 0.28 10.9 19.3 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor F-protein PF00469.20 CDI81103.1 - 0.29 10.7 19.9 0.33 10.5 19.9 1.0 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Lin-8 PF03353.15 CDI81103.1 - 0.7 9.4 34.4 0.83 9.2 34.4 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF5523 PF17661.1 CDI81103.1 - 0.77 9.4 22.1 1.2 8.7 22.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5523) TFIIA PF03153.13 CDI81103.1 - 0.9 9.5 53.1 1 9.3 53.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Myc_N PF01056.18 CDI81103.1 - 1.4 8.7 14.7 1.7 8.5 14.7 1.1 1 0 0 1 1 1 0 Myc amino-terminal region PNISR PF15996.5 CDI81103.1 - 1.6 9.0 27.6 2 8.7 27.6 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Presenilin PF01080.17 CDI81103.1 - 1.9 7.2 27.7 2 7.1 27.7 1.0 1 0 0 1 1 1 0 Presenilin Pan_kinase PF03309.14 CDI81103.1 - 2 8.2 7.8 2.4 7.9 7.8 1.1 1 0 0 1 1 1 0 Type III pantothenate kinase CSRNP_N PF16019.5 CDI81103.1 - 2.2 8.2 22.4 2.6 7.9 22.4 1.0 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF4050 PF13259.6 CDI81103.1 - 2.2 8.6 18.3 2.5 8.4 18.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Afi1 PF07792.12 CDI81103.1 - 2.8 8.4 21.0 3.3 8.2 21.0 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Bud13 PF09736.9 CDI81103.1 - 2.9 8.3 27.1 4.4 7.7 27.1 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex CDC45 PF02724.14 CDI81103.1 - 3.2 5.9 20.5 3.5 5.8 20.5 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4746 PF15928.5 CDI81103.1 - 4.1 6.7 18.4 4.8 6.5 18.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) V_ATPase_I PF01496.19 CDI81103.1 - 4.5 5.1 23.7 4.9 4.9 23.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI81103.1 - 5.4 5.9 16.6 7 5.6 16.6 1.2 1 0 0 1 1 1 0 CLN3 protein RR_TM4-6 PF06459.12 CDI81103.1 - 5.5 6.7 27.2 6.3 6.5 27.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Mem_trans PF03547.18 CDI81103.1 - 5.6 5.3 10.6 5.8 5.2 10.6 1.0 1 0 0 1 1 1 0 Membrane transport protein DUF913 PF06025.12 CDI81103.1 - 6.1 5.7 15.1 7.4 5.4 15.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 CDI81103.1 - 6.6 6.7 18.5 8.5 6.3 18.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A eIF-3_zeta PF05091.12 CDI81103.1 - 6.6 5.6 27.5 7.5 5.4 27.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CAML PF14963.6 CDI81103.1 - 8 6.5 10.2 9.2 6.3 10.2 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand hDGE_amylase PF14701.6 CDI81103.1 - 8.5 5.3 16.1 8.9 5.3 16.1 1.0 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Neur_chan_memb PF02932.16 CDI81103.1 - 8.7 6.3 21.3 9.5 6.2 21.3 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2052 PF09747.9 CDI81103.1 - 8.8 6.4 27.0 11 6.1 27.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) UPF0565 PF10561.9 CDI81103.1 - 9.4 5.3 16.2 11 5.1 16.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Kinesin_assoc PF16183.5 CDI81103.1 - 9.6 6.3 8.8 12 6.0 8.8 1.1 1 0 0 1 1 1 0 Kinesin-associated CobT PF06213.12 CDI81103.1 - 9.6 5.5 37.4 11 5.3 37.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SR-25 PF10500.9 CDI81105.1 - 0.0046 16.6 2.7 0.0046 16.6 2.7 10.2 4 1 5 9 9 9 5 Nuclear RNA-splicing-associated protein Mak16 PF04874.14 CDI81107.1 - 1.5 9.4 18.5 0.54 10.9 10.2 2.7 2 0 0 2 2 2 0 Mak16 protein C-terminal region eIF-3_zeta PF05091.12 CDI81107.1 - 7.9 5.3 36.8 0.5 9.3 14.1 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PT PF04886.12 CDI81113.1 - 0.0015 18.0 8.9 0.023 14.2 0.4 3.4 1 1 1 2 2 2 2 PT repeat DUF2722 PF10846.8 CDI81116.1 - 0.00059 18.9 5.3 0.00077 18.5 5.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) EIIBC-GUT_N PF03612.14 CDI81116.1 - 0.031 14.0 1.0 0.06 13.1 1.0 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Orf78 PF06024.12 CDI81116.1 - 0.095 13.0 0.1 0.22 11.9 0.1 1.5 1 0 0 1 1 1 0 Orf78 (ac78) DUF2207 PF09972.9 CDI81116.1 - 0.1 11.4 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF775 PF05603.12 CDI81116.1 - 0.13 11.8 5.0 0.23 10.9 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Spt20 PF12090.8 CDI81116.1 - 0.15 11.7 18.7 0.29 10.7 18.7 1.5 1 0 0 1 1 1 0 Spt20 family Suf PF05843.14 CDI81116.1 - 2.9 7.8 8.7 0.15 12.1 3.6 1.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF5336 PF17270.2 CDI81116.1 - 5.8 6.5 18.1 0.13 11.8 9.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5336) Pex14_N PF04695.13 CDI81116.1 - 6.8 7.3 18.5 0.32 11.7 8.9 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Peptidase_C65 PF10275.9 CDI81118.1 - 7.9e-21 74.6 1.0 1.7e-20 73.5 1.0 1.5 1 1 0 1 1 1 1 Peptidase C65 Otubain TFIIA PF03153.13 CDI81118.1 - 0.0003 20.9 11.8 0.00032 20.8 11.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Chorion_2 PF03964.15 CDI81118.1 - 0.0051 17.6 6.2 0.0051 17.6 6.2 2.0 2 0 0 2 2 2 1 Chorion family 2 RskA PF10099.9 CDI81118.1 - 0.0085 16.4 8.5 0.014 15.7 8.5 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Med15 PF09606.10 CDI81118.1 - 0.01 14.6 12.9 0.012 14.3 12.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ndc1_Nup PF09531.10 CDI81118.1 - 0.02 13.6 3.3 0.023 13.4 3.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Activator_LAG-3 PF11498.8 CDI81118.1 - 0.033 13.2 17.6 0.043 12.8 17.6 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Hamartin PF04388.12 CDI81118.1 - 0.055 12.1 3.9 0.061 12.0 3.9 1.0 1 0 0 1 1 1 0 Hamartin protein DUF3336 PF11815.8 CDI81118.1 - 0.12 12.1 2.3 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3336) IHABP4_N PF16174.5 CDI81118.1 - 0.14 12.7 8.2 0.21 12.2 8.2 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal IMUP PF15761.5 CDI81118.1 - 0.16 12.6 5.8 0.38 11.5 5.8 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 CDI81118.1 - 0.72 9.4 12.7 0.082 12.5 3.9 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein PepSY_TM PF03929.16 CDI81118.1 - 4.1 7.0 9.2 11 5.6 9.2 1.7 1 1 0 1 1 1 0 PepSY-associated TM region mTERF PF02536.14 CDI81119.1 - 4.3e-12 45.6 0.1 5.5e-10 38.7 0.0 2.3 2 0 0 2 2 2 2 mTERF RskA PF10099.9 CDI81119.1 - 0.0048 17.2 0.0 0.0048 17.2 0.0 6.3 2 1 2 5 5 5 1 Anti-sigma-K factor rskA DUF1645 PF07816.11 CDI81119.1 - 0.0067 17.0 1.3 0.0067 17.0 1.3 4.2 4 1 0 4 4 4 1 Protein of unknown function (DUF1645) DUF2098 PF09871.9 CDI81119.1 - 0.04 14.3 0.2 0.04 14.3 0.2 3.3 4 1 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2098) IF-2B PF01008.17 CDI81120.1 - 2e-09 37.1 0.4 9.2e-09 34.9 0.4 1.9 1 1 0 1 1 1 1 Initiation factor 2 subunit family Spt20 PF12090.8 CDI81120.1 - 1.7e-07 31.1 38.5 5.2e-06 26.2 8.4 2.6 2 0 0 2 2 2 2 Spt20 family DUF2722 PF10846.8 CDI81120.1 - 0.00026 20.1 9.3 0.00026 20.1 9.3 2.8 2 1 0 2 2 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI81120.1 - 0.00077 19.6 10.4 0.00077 19.6 10.4 2.4 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Peptidase_S49_N PF08496.10 CDI81120.1 - 0.0013 18.8 8.0 0.0054 16.8 0.0 2.4 2 0 0 2 2 2 1 Peptidase family S49 N-terminal Band_3_cyto PF07565.13 CDI81120.1 - 0.0065 16.3 1.5 0.0065 16.3 1.5 2.4 2 0 0 2 2 2 1 Band 3 cytoplasmic domain DUF4746 PF15928.5 CDI81120.1 - 0.014 14.8 6.7 0.066 12.6 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) EPL1 PF10513.9 CDI81120.1 - 0.026 14.9 16.5 0.047 14.1 1.2 2.7 3 0 0 3 3 3 0 Enhancer of polycomb-like MPM1 PF17234.2 CDI81120.1 - 0.027 14.7 1.1 0.027 14.7 1.1 2.7 3 0 0 3 3 2 0 Mitochondrial peculiar membrane protein 1 SLC12 PF03522.15 CDI81120.1 - 0.065 12.2 9.3 0.41 9.6 1.1 2.2 2 0 0 2 2 2 0 Solute carrier family 12 SpoIIP PF07454.11 CDI81120.1 - 0.21 11.0 13.8 0.49 9.8 2.1 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) RNase_H2_suC PF08615.11 CDI81120.1 - 0.35 11.0 7.3 9.1e+02 -0.0 0.0 3.5 1 1 1 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Eapp_C PF10238.9 CDI81120.1 - 0.5 10.4 17.4 0.12 12.5 0.8 2.8 3 0 0 3 3 2 0 E2F-associated phosphoprotein DUF4471 PF14740.6 CDI81120.1 - 0.53 9.5 8.6 0.21 10.8 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) DUF702 PF05142.12 CDI81120.1 - 1.2 9.7 19.3 0.27 11.7 1.7 2.9 3 0 0 3 3 2 0 Domain of unknown function (DUF702) FAM176 PF14851.6 CDI81120.1 - 1.2 8.8 8.3 1.1 8.9 0.6 2.6 2 0 0 2 2 2 0 FAM176 family DUF4770 PF15994.5 CDI81120.1 - 1.4 9.1 26.2 0.22 11.8 7.7 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4770) FAM76 PF16046.5 CDI81120.1 - 3 7.1 24.7 0.013 14.9 2.1 3.0 3 1 1 4 4 3 0 FAM76 protein MMR1 PF08505.10 CDI81120.1 - 3 8.0 26.3 1 9.6 3.5 3.1 3 0 0 3 3 3 0 Mitochondrial Myo2 receptor-related protein CTU2 PF10288.9 CDI81120.1 - 3.4 7.9 24.1 3.1 8.1 0.2 3.6 3 0 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 SR-25 PF10500.9 CDI81120.1 - 5.1 6.7 34.4 0.39 10.3 13.4 3.5 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein MecA PF05389.12 CDI81120.1 - 5.7 6.5 10.3 0.45 10.1 0.3 2.3 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) LCIB_C_CA PF18599.1 CDI81120.1 - 5.8 6.1 9.2 7.9 5.7 0.7 2.4 2 0 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases MDM10 PF12519.8 CDI81120.1 - 5.9 5.6 12.0 6.5 5.5 1.2 2.2 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 Zip PF02535.22 CDI81120.1 - 6 6.0 7.5 8.6 5.5 0.5 2.4 3 0 0 3 3 3 0 ZIP Zinc transporter NST1 PF13945.6 CDI81120.1 - 6.5 6.8 27.2 1.6 8.8 7.6 2.9 3 0 0 3 3 3 0 Salt tolerance down-regulator Exonuc_VII_L PF02601.15 CDI81120.1 - 6.6 6.2 22.3 4.1 6.9 2.7 2.6 2 1 0 2 2 2 0 Exonuclease VII, large subunit DUF2126 PF09899.9 CDI81120.1 - 6.9 4.6 11.5 0.29 9.2 0.7 2.1 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) eIF-3_zeta PF05091.12 CDI81120.1 - 9.3 5.1 26.3 2.6 6.9 10.1 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ARS2 PF04959.13 CDI81121.1 - 1.4e-09 38.6 0.5 1.4e-09 38.6 0.5 1.7 1 1 0 1 1 1 1 Arsenite-resistance protein 2 RRN3 PF05327.11 CDI81121.1 - 0.00068 18.3 0.5 0.00084 18.0 0.5 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 CPSF100_C PF13299.6 CDI81121.1 - 0.14 12.3 0.7 0.26 11.5 0.7 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF1635 PF07795.11 CDI81121.1 - 0.15 11.9 8.6 0.43 10.4 8.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) GET2 PF08690.10 CDI81121.1 - 0.35 10.5 5.4 0.49 10.0 5.4 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Tmemb_9 PF05434.11 CDI81121.1 - 0.64 9.9 7.9 1.6 8.7 7.9 1.6 1 0 0 1 1 1 0 TMEM9 Presenilin PF01080.17 CDI81121.1 - 1 8.0 3.0 1.3 7.7 3.0 1.2 1 0 0 1 1 1 0 Presenilin DUF3801 PF12687.7 CDI81121.1 - 1.2 9.2 6.2 2.8 8.0 6.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3801) zf-C2H2 PF00096.26 CDI81121.1 - 1.9 9.1 6.0 4.7 7.9 6.0 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type PRP38_assoc PF12871.7 CDI81121.1 - 6.3 7.5 17.7 6.4 7.4 10.2 2.3 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Rotamase_2 PF13145.6 CDI81121.1 - 9.6 7.1 7.8 60 4.5 0.4 3.2 3 0 0 3 3 3 0 PPIC-type PPIASE domain Enkurin PF13864.6 CDI81127.1 - 0.0031 17.9 4.1 0.0031 17.9 4.1 2.1 2 0 0 2 2 2 1 Calmodulin-binding Med15 PF09606.10 CDI81127.1 - 0.77 8.4 30.9 1.1 7.9 30.9 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal YfhO PF09586.10 CDI81127.1 - 0.84 7.8 11.1 1 7.5 11.1 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF1635 PF07795.11 CDI81127.1 - 0.87 9.4 24.3 0.35 10.7 11.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DUF4407 PF14362.6 CDI81127.1 - 5 6.4 18.1 8.4 5.6 18.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CBP4 PF07960.11 CDI81127.1 - 9.6 6.1 16.9 1.7 8.5 8.9 2.2 2 0 0 2 2 2 0 CBP4 DUF3381 PF11861.8 CDI81131.1 - 0.0063 16.3 3.8 0.13 12.0 4.6 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3381) DUF755 PF05501.11 CDI81131.1 - 0.0094 16.2 25.6 0.0094 16.2 25.6 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF755) TFIIF_alpha PF05793.12 CDI81131.1 - 0.032 12.8 12.6 0.043 12.4 12.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Roughex PF06020.11 CDI81131.1 - 0.11 11.6 16.8 0.26 10.3 16.8 1.7 1 0 0 1 1 1 0 Drosophila roughex protein DUF1635 PF07795.11 CDI81131.1 - 0.12 12.2 16.8 0.22 11.4 16.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) MAP65_ASE1 PF03999.12 CDI81131.1 - 0.34 9.5 16.1 0.44 9.2 16.1 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) NPR3 PF03666.13 CDI81131.1 - 0.93 8.2 10.1 1.2 7.8 10.1 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SR-25 PF10500.9 CDI81131.1 - 1.7 8.2 21.6 0.79 9.3 16.6 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF908 PF06012.12 CDI81131.1 - 2.1 7.7 22.4 4.5 6.6 17.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Utp14 PF04615.13 CDI81131.1 - 2.2 6.7 23.6 2.8 6.4 23.6 1.2 1 0 0 1 1 1 0 Utp14 protein PI3K_1B_p101 PF10486.9 CDI81131.1 - 6.1 4.5 10.5 9 3.9 10.5 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Hid1 PF12722.7 CDI81131.1 - 6.3 4.8 16.3 7.8 4.5 16.3 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Hamartin PF04388.12 CDI81131.1 - 9.2 4.8 15.5 14 4.2 15.5 1.3 1 0 0 1 1 1 0 Hamartin protein Shadoo PF14999.6 CDI81135.1 - 0.002 18.2 2.1 0.0028 17.7 2.1 1.2 1 0 0 1 1 1 1 Shadow of prion protein, neuroprotective CCSAP PF15748.5 CDI81135.1 - 0.24 11.5 38.8 0.28 11.3 38.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CDC45 PF02724.14 CDI81135.1 - 0.3 9.3 27.5 0.3 9.3 27.5 1.0 1 0 0 1 1 1 0 CDC45-like protein MAP7 PF05672.11 CDI81135.1 - 0.43 10.3 51.2 0.53 10.0 51.2 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family VIR_N PF15912.5 CDI81135.1 - 0.49 10.0 23.7 0.62 9.6 23.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal RR_TM4-6 PF06459.12 CDI81135.1 - 0.56 10.0 34.6 0.69 9.7 34.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MMR1 PF08505.10 CDI81135.1 - 1.1 9.5 41.2 1.3 9.2 41.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Presenilin PF01080.17 CDI81135.1 - 1.1 7.9 44.3 1.2 7.8 44.3 1.1 1 0 0 1 1 1 0 Presenilin RIFIN PF02009.16 CDI81135.1 - 1.2 8.9 21.5 1.6 8.6 21.5 1.1 1 0 0 1 1 1 0 Rifin DUF1387 PF07139.11 CDI81135.1 - 1.3 8.7 32.2 1.5 8.4 32.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) FAM60A PF15396.6 CDI81135.1 - 1.3 8.9 27.9 1.7 8.6 27.9 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Caldesmon PF02029.15 CDI81135.1 - 1.5 7.5 34.9 1.7 7.3 34.9 1.0 1 0 0 1 1 1 0 Caldesmon Rtf2 PF04641.12 CDI81135.1 - 1.6 8.0 27.8 2.1 7.7 27.8 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger DUF572 PF04502.13 CDI81135.1 - 1.9 8.0 30.7 2 8.0 30.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Asp-B-Hydro_N PF05279.11 CDI81135.1 - 3 7.8 26.0 3.4 7.7 26.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Exonuc_VII_L PF02601.15 CDI81135.1 - 3.5 7.1 41.4 4.4 6.8 41.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit CDK5_activator PF03261.15 CDI81135.1 - 4.5 6.7 25.5 4.9 6.6 25.5 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein SAPS PF04499.15 CDI81135.1 - 4.5 5.9 24.2 5 5.8 24.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PA26 PF04636.13 CDI81135.1 - 5.1 5.9 24.7 5.6 5.8 24.7 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Endostatin PF06482.11 CDI81135.1 - 5.1 6.5 32.9 7.3 6.0 32.9 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin FapA PF03961.13 CDI81135.1 - 5.4 5.5 19.2 5.7 5.4 19.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A PPP4R2 PF09184.11 CDI81135.1 - 5.7 6.4 18.9 7 6.2 18.9 1.2 1 0 0 1 1 1 0 PPP4R2 Hamartin PF04388.12 CDI81135.1 - 5.9 5.4 31.6 6.6 5.3 31.6 1.1 1 0 0 1 1 1 0 Hamartin protein Zip PF02535.22 CDI81135.1 - 6.4 5.9 25.8 8 5.6 25.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 CDI81135.1 - 6.6 5.2 29.8 6.9 5.1 29.8 1.0 1 0 0 1 1 1 0 Macoilin family DUF4045 PF13254.6 CDI81135.1 - 7.1 6.2 33.9 7.5 6.1 33.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SLC12 PF03522.15 CDI81135.1 - 9.7 5.1 38.0 12 4.8 38.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 MMU163 PF17119.5 CDI81137.1 - 0.00061 19.0 2.3 0.00075 18.7 2.3 1.1 1 0 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis Podoplanin PF05808.11 CDI81137.1 - 0.0027 17.8 3.2 0.0034 17.5 3.2 1.1 1 0 0 1 1 1 1 Podoplanin SR-25 PF10500.9 CDI81137.1 - 0.0052 16.4 21.4 0.0073 16.0 21.4 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI81137.1 - 0.046 13.3 9.0 0.054 13.1 9.0 1.1 1 0 0 1 1 1 0 Spt20 family RskA PF10099.9 CDI81137.1 - 0.054 13.8 11.3 0.065 13.5 11.3 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Paf1 PF03985.13 CDI81137.1 - 0.078 12.0 9.6 0.089 11.8 9.6 1.0 1 0 0 1 1 1 0 Paf1 Lin-8 PF03353.15 CDI81137.1 - 0.094 12.3 7.6 0.11 12.1 7.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PMSI1 PF15322.6 CDI81137.1 - 0.098 12.1 9.2 0.13 11.7 9.2 1.2 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Rrn6 PF10214.9 CDI81137.1 - 0.099 11.1 10.1 0.12 10.9 10.1 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Macoilin PF09726.9 CDI81137.1 - 0.11 11.0 7.1 0.13 10.8 7.1 1.2 1 0 0 1 1 1 0 Macoilin family Smg8_Smg9 PF10220.9 CDI81137.1 - 0.15 10.4 4.2 0.14 10.4 4.2 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Presenilin PF01080.17 CDI81137.1 - 0.17 10.6 5.7 0.19 10.5 5.7 1.1 1 0 0 1 1 1 0 Presenilin NEMP PF10225.9 CDI81137.1 - 0.19 11.4 0.2 0.19 11.4 0.2 1.1 1 0 0 1 1 1 0 NEMP family Miga PF10265.9 CDI81137.1 - 0.22 10.4 5.3 0.25 10.3 5.3 1.0 1 0 0 1 1 1 0 Mitoguardin GREB1 PF15782.5 CDI81137.1 - 0.34 8.0 9.6 0.38 7.8 9.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Apt1 PF10351.9 CDI81137.1 - 0.4 9.5 10.4 0.43 9.4 10.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain PAP1 PF08601.10 CDI81137.1 - 0.4 10.4 13.2 0.5 10.0 13.2 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Plasmodium_Vir PF05795.11 CDI81137.1 - 0.45 9.9 4.3 0.49 9.7 4.3 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SPX PF03105.19 CDI81137.1 - 0.58 10.0 11.3 0.65 9.8 11.3 1.0 1 0 0 1 1 1 0 SPX domain RAP1 PF07218.11 CDI81137.1 - 0.75 8.0 9.8 0.73 8.0 9.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ALMT PF11744.8 CDI81137.1 - 1.1 8.0 3.7 1.3 7.8 3.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PI3K_1B_p101 PF10486.9 CDI81137.1 - 1.5 6.5 11.1 1.6 6.4 11.1 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit AF-4 PF05110.13 CDI81137.1 - 2.1 6.3 27.5 2.4 6.1 27.5 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Hid1 PF12722.7 CDI81137.1 - 2.1 6.4 5.5 2.2 6.3 5.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CCDC106 PF15794.5 CDI81137.1 - 2.4 7.8 16.9 3.2 7.4 16.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 ANAPC_CDC26 PF10471.9 CDI81137.1 - 2.7 8.9 17.2 1.9 9.4 15.6 1.5 2 0 0 2 2 1 0 Anaphase-promoting complex APC subunit CDC26 Pannexin_like PF12534.8 CDI81137.1 - 3 6.8 4.6 3.7 6.5 4.6 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Herpes_pp85 PF04637.12 CDI81137.1 - 6.5 5.1 9.7 8.3 4.7 9.7 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) SUIM_assoc PF16619.5 CDI81140.1 - 0.00086 19.3 5.7 0.00086 19.3 5.7 6.9 5 1 1 7 7 7 2 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI81140.1 - 0.0096 15.6 16.1 0.0096 15.6 16.1 3.8 2 1 1 3 3 3 1 Spt20 family Med3 PF11593.8 CDI81140.1 - 0.012 14.8 5.6 0.012 14.8 5.6 5.2 4 1 0 5 5 5 0 Mediator complex subunit 3 fungal DUF1840 PF08895.11 CDI81140.1 - 8.1 6.8 27.1 3.4 8.1 8.1 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) DUF3678 PF12435.8 CDI81149.1 - 0.059 12.8 7.6 0.23 10.9 7.6 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) EDR1 PF14381.6 CDI81150.1 - 9.3e-17 61.4 0.0 2.4e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 Ethylene-responsive protein kinase Le-CTR1 LRR_6 PF13516.6 CDI81150.1 - 4.9e-08 32.4 1.1 1.7 8.9 0.0 5.9 6 0 0 6 6 6 3 Leucine Rich repeat DUF4667 PF15700.5 CDI81150.1 - 0.0023 18.1 9.5 0.0023 18.1 9.5 7.3 5 2 1 6 6 6 2 Domain of unknown function (DUF4667) LRR_1 PF00560.33 CDI81150.1 - 0.0053 17.1 6.9 50 5.0 0.0 6.7 5 1 0 5 5 5 0 Leucine Rich Repeat RskA PF10099.9 CDI81174.1 - 0.00075 19.8 5.0 0.0009 19.6 5.0 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI81174.1 - 0.049 13.6 18.7 0.056 13.4 18.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CDI81174.1 - 0.56 7.3 16.0 0.61 7.1 16.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Menin PF05053.13 CDI81174.1 - 7.4 4.8 13.2 9.1 4.5 13.2 1.3 1 0 0 1 1 1 0 Menin Eapp_C PF10238.9 CDI81182.1 - 0.12 12.4 1.7 0.24 11.5 1.7 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein ANAPC_CDC26 PF10471.9 CDI81182.1 - 0.72 10.7 7.5 0.17 12.7 3.2 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 DUF4808 PF16066.5 CDI81182.1 - 2.1 8.9 6.0 4.3 7.9 6.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4808) RskA PF10099.9 CDI81184.1 - 5.4e-10 39.8 41.6 0.0069 16.7 11.7 3.6 1 1 1 2 2 2 2 Anti-sigma-K factor rskA Cyt_bd_oxida_II PF02322.15 CDI81184.1 - 0.0036 16.7 1.3 0.0036 16.7 1.3 1.7 2 1 0 2 2 2 1 Cytochrome bd terminal oxidase subunit II SUIM_assoc PF16619.5 CDI81184.1 - 0.0073 16.4 4.4 0.0073 16.4 4.4 7.2 4 2 0 4 4 2 1 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 CDI81184.1 - 0.092 11.7 0.1 0.092 11.7 0.1 4.2 3 1 1 4 4 2 0 Protein of unknown function (DUF2722) DUF4199 PF13858.6 CDI81184.1 - 0.11 13.0 0.0 0.11 13.0 0.0 3.4 2 1 0 2 2 1 0 Protein of unknown function (DUF4199) SID-1_RNA_chan PF13965.6 CDI81184.1 - 0.14 10.5 21.8 0.33 9.3 2.2 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 PRCC PF10253.9 CDI81184.1 - 0.29 11.9 44.9 0.17 12.7 11.7 2.6 1 1 1 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting Ac76 PF05814.11 CDI81184.1 - 0.9 9.6 11.0 1.6 8.8 0.1 3.6 3 1 0 3 3 3 0 Orf76 (Ac76) LAP1C PF05609.12 CDI81184.1 - 1.5 7.8 41.8 0.026 13.6 30.5 2.3 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) TFIIF_alpha PF05793.12 CDI81184.1 - 1.8 7.1 28.0 0.049 12.2 21.8 1.5 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GPDPase_memb PF10110.9 CDI81184.1 - 2 7.1 7.0 1 8.0 0.4 2.6 2 0 0 2 2 2 0 Membrane domain of glycerophosphoryl diester phosphodiesterase CDC45 PF02724.14 CDI81184.1 - 2.6 6.2 33.6 0.35 9.1 28.3 2.0 2 1 0 2 2 2 0 CDC45-like protein DUF4179 PF13786.6 CDI81184.1 - 5.1 7.6 0.0 5.1 7.6 0.0 4.7 2 1 1 3 3 2 0 Domain of unknown function (DUF4179) YfhO PF09586.10 CDI81184.1 - 9.5 4.3 21.7 0.092 11.0 1.6 2.1 2 0 0 2 2 2 0 Bacterial membrane protein YfhO zf-C3HC4_4 PF15227.6 CDI81191.1 - 0.024 14.8 2.5 0.052 13.7 2.5 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RAP PF08373.10 CDI81211.1 - 6.4e-16 58.2 0.0 1e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 RAP domain DUF559 PF04480.12 CDI81211.1 - 0.31 10.9 2.5 0.37 10.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF559) SR-25 PF10500.9 CDI81212.1 - 0.025 14.2 9.0 0.044 13.4 9.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FeS PF04060.13 CDI81212.1 - 0.44 10.3 5.5 9.9 5.9 0.4 3.1 2 0 0 2 2 2 0 Putative Fe-S cluster DUF3446 PF11928.8 CDI81212.1 - 9.2 6.7 17.3 0.27 11.6 5.8 3.2 3 0 0 3 3 3 0 Early growth response N-terminal domain Sporozoite_P67 PF05642.11 CDI81218.1 - 1.6e-07 29.9 15.2 1.6e-07 29.9 15.2 1.3 1 1 0 1 1 1 1 Sporozoite P67 surface antigen Presenilin PF01080.17 CDI81218.1 - 7.7e-05 21.6 52.7 0.00052 18.9 34.3 2.2 2 0 0 2 2 2 2 Presenilin Activator_LAG-3 PF11498.8 CDI81218.1 - 0.0016 17.5 19.1 0.0016 17.5 19.1 3.1 2 1 1 3 3 3 1 Transcriptional activator LAG-3 Tetraspanin PF00335.20 CDI81218.1 - 0.0072 16.1 0.0 0.037 13.7 0.0 1.9 1 1 0 1 1 1 1 Tetraspanin family Coilin_N PF15862.5 CDI81218.1 - 0.011 15.6 3.6 0.011 15.6 3.6 3.9 2 1 0 2 2 2 0 Coilin N-terminus CCSAP PF15748.5 CDI81218.1 - 0.16 12.2 59.5 0.31 11.2 40.5 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated SOBP PF15279.6 CDI81218.1 - 1.8 9.1 44.2 0.17 12.4 24.8 2.1 2 0 0 2 2 2 0 Sine oculis-binding protein FAM199X PF15814.5 CDI81219.1 - 0.00071 18.7 24.7 0.00086 18.5 24.7 1.1 1 0 0 1 1 1 1 Protein family FAM199X eIF-3_zeta PF05091.12 CDI81219.1 - 0.023 13.7 16.5 0.022 13.7 16.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) HemX PF04375.14 CDI81219.1 - 0.084 12.2 22.3 0.082 12.2 22.3 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase CCSAP PF15748.5 CDI81219.1 - 0.16 12.2 27.5 0.2 11.8 27.5 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated NARP1 PF12569.8 CDI81219.1 - 0.18 10.7 12.2 0.2 10.5 12.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4407 PF14362.6 CDI81219.1 - 0.19 11.1 12.8 0.2 11.0 12.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SprA-related PF12118.8 CDI81219.1 - 0.34 10.0 37.8 0.52 9.4 37.8 1.3 1 0 0 1 1 1 0 SprA-related family Suf PF05843.14 CDI81219.1 - 0.44 10.5 20.3 0.52 10.3 20.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Caldesmon PF02029.15 CDI81219.1 - 0.66 8.7 19.3 0.75 8.5 19.3 1.0 1 0 0 1 1 1 0 Caldesmon DUF4175 PF13779.6 CDI81219.1 - 0.91 7.4 32.2 1 7.2 32.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PAT1 PF09770.9 CDI81219.1 - 0.96 7.6 23.9 1 7.6 23.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 V_ATPase_I PF01496.19 CDI81219.1 - 1.1 7.0 15.2 1.1 7.1 15.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2828 PF11443.8 CDI81219.1 - 1.8 6.6 13.9 2 6.4 13.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Velvet PF11754.8 CDI81219.1 - 1.9 8.4 24.5 2.4 8.0 24.5 1.2 1 0 0 1 1 1 0 Velvet factor DUF2126 PF09899.9 CDI81219.1 - 2.4 6.1 9.5 2.4 6.1 9.5 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Ureide_permease PF07168.11 CDI81219.1 - 2.5 6.7 9.7 2.6 6.7 9.7 1.2 1 0 0 1 1 1 0 Ureide permease Presenilin PF01080.17 CDI81219.1 - 2.7 6.7 26.6 3.1 6.5 26.6 1.1 1 0 0 1 1 1 0 Presenilin XRCC4 PF06632.12 CDI81219.1 - 3.1 6.6 17.4 3.8 6.3 17.4 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 CDC45 PF02724.14 CDI81219.1 - 4.8 5.3 16.6 5.1 5.3 16.6 1.0 1 0 0 1 1 1 0 CDC45-like protein PA26 PF04636.13 CDI81219.1 - 5.1 5.9 17.7 5.5 5.8 17.7 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) VESA1_N PF12785.7 CDI81219.1 - 6 5.7 29.6 6.6 5.6 29.6 1.0 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 Tim54 PF11711.8 CDI81219.1 - 6.1 5.5 17.6 8.1 5.1 17.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Serinc PF03348.15 CDI81219.1 - 8 5.3 18.5 9.8 5.0 18.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Peptidase_S49_N PF08496.10 CDI81219.1 - 8.4 6.4 14.4 11 6.1 14.4 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MAP70 PF07058.11 CDI81219.1 - 9.1 4.9 20.2 10 4.7 20.2 1.0 1 0 0 1 1 1 0 Microtubule-associated protein 70 Cellulose_synt PF03552.14 CDI81219.1 - 9.6 4.6 13.7 11 4.3 13.7 1.0 1 0 0 1 1 1 0 Cellulose synthase Presenilin PF01080.17 CDI81222.1 - 2.4 6.8 58.5 0.65 8.7 21.3 2.4 2 0 0 2 2 2 0 Presenilin FAM60A PF15396.6 CDI81222.1 - 4.2 7.3 37.8 1.6 8.7 11.1 2.5 2 0 0 2 2 2 0 Protein Family FAM60A DUF572 PF04502.13 CDI81222.1 - 6.6 6.3 43.2 6.1 6.4 22.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) GAGA_bind PF06217.12 CDI81222.1 - 7 6.8 44.1 0.83 9.9 20.1 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family Lin-8 PF03353.15 CDI81230.1 - 5.7 6.4 10.3 5.5 6.5 10.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TOH_N PF12549.8 CDI81231.1 - 0.24 11.3 1.7 0.92 9.4 1.7 2.1 1 0 0 1 1 1 0 Tyrosine hydroxylase N terminal DUF3675 PF12428.8 CDI81234.1 - 0.00094 19.7 2.9 0.0063 17.1 0.6 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3675) Oxidored_q3 PF00499.20 CDI81234.1 - 0.012 15.3 3.1 0.15 11.7 3.1 2.3 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Yip1 PF04893.17 CDI81234.1 - 0.012 15.3 2.7 2.1 8.1 0.0 3.0 2 1 0 3 3 3 0 Yip1 domain KASH PF10541.9 CDI81234.1 - 0.048 13.9 5.8 0.92 9.8 0.9 2.4 2 0 0 2 2 2 0 Nuclear envelope localisation domain Trp_oprn_chp PF09534.10 CDI81234.1 - 0.076 12.8 25.9 0.061 13.1 6.0 3.0 1 1 2 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2207 PF09972.9 CDI81234.1 - 0.093 11.5 1.1 0.23 10.2 1.1 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) RSN1_TM PF13967.6 CDI81234.1 - 0.14 11.9 0.1 7.7 6.3 0.0 2.3 2 0 0 2 2 2 0 Late exocytosis, associated with Golgi transport BAF1_ABF1 PF04684.13 CDI81234.1 - 0.16 11.0 11.0 0.26 10.3 11.0 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF572 PF04502.13 CDI81234.1 - 0.33 10.6 10.8 0.54 9.8 10.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) AF-4 PF05110.13 CDI81234.1 - 0.46 8.5 23.5 0.57 8.2 23.5 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein 7tm_1 PF00001.21 CDI81234.1 - 0.47 9.7 5.9 1.1 8.5 5.6 1.8 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) Consortin_C PF15281.6 CDI81234.1 - 0.62 10.1 3.2 2.4 8.2 0.6 2.5 2 0 0 2 2 2 0 Consortin C-terminus Peptidase_S64 PF08192.11 CDI81234.1 - 0.72 8.3 18.1 0.94 7.9 18.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 EphA2_TM PF14575.6 CDI81234.1 - 1 10.3 0.0 1 10.3 0.0 3.8 2 1 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain SLC12 PF03522.15 CDI81234.1 - 1.1 8.2 15.0 1.4 7.8 15.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Conotoxin PF02950.17 CDI81234.1 - 1.2 10.2 21.0 1.6 9.8 1.7 3.4 3 1 0 3 3 3 0 Conotoxin SARAF PF06682.12 CDI81234.1 - 1.6 8.3 16.2 0.68 9.5 14.0 1.5 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3357 PF11837.8 CDI81234.1 - 1.9 9.0 16.0 0.41 11.1 4.2 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) bMG10 PF17973.1 CDI81234.1 - 2.8 8.1 7.5 1.7 8.8 0.5 2.5 3 0 0 3 3 2 0 Bacterial Alpha-2-macroglobulin MG10 domain DivIC PF04977.15 CDI81234.1 - 3.4 7.5 36.7 2.7 7.8 11.9 3.2 3 0 0 3 3 3 0 Septum formation initiator Draxin PF15550.6 CDI81234.1 - 5.1 6.9 14.9 6.5 6.5 14.9 1.0 1 0 0 1 1 1 0 Draxin CD20 PF04103.15 CDI81234.1 - 5.2 7.1 8.5 0.34 11.0 1.5 2.4 1 1 1 2 2 2 0 CD20-like family Chordopox_A13L PF05961.11 CDI81234.1 - 8.2 6.7 6.1 5 7.4 0.0 3.0 4 0 0 4 4 4 0 Chordopoxvirus A13L protein AAA PF00004.29 CDI81238.1 - 3.1e-07 30.9 10.6 0.00023 21.6 0.0 4.5 4 1 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) Spt20 PF12090.8 CDI81238.1 - 0.00019 21.1 14.2 0.00019 21.1 14.2 6.3 3 2 2 5 5 5 1 Spt20 family Ribosomal_60s PF00428.19 CDI81238.1 - 0.13 12.9 0.3 0.069 13.7 5.3 6.9 6 1 0 6 6 6 0 60s Acidic ribosomal protein SR-25 PF10500.9 CDI81238.1 - 0.78 9.3 49.8 0.13 11.9 13.9 4.2 5 0 0 5 5 5 0 Nuclear RNA-splicing-associated protein Apt1 PF10351.9 CDI81238.1 - 2.3 7.0 30.6 0.31 9.8 2.9 3.4 3 0 0 3 3 3 0 Golgi-body localisation protein domain RPN2_C PF18004.1 CDI81239.1 - 0.0013 18.7 17.5 0.0018 18.2 17.5 1.2 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain CDC45 PF02724.14 CDI81239.1 - 0.0017 16.8 10.0 0.002 16.5 10.0 1.1 1 0 0 1 1 1 1 CDC45-like protein DUF4746 PF15928.5 CDI81239.1 - 0.0018 17.7 6.4 0.002 17.6 6.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) Vfa1 PF08432.10 CDI81239.1 - 0.0057 17.0 17.7 0.0081 16.5 17.7 1.3 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 RNA_polI_A34 PF08208.11 CDI81239.1 - 0.023 14.8 12.8 0.043 13.9 12.8 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 AP3D1 PF06375.11 CDI81239.1 - 0.031 14.5 19.5 0.047 13.9 19.5 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 RR_TM4-6 PF06459.12 CDI81239.1 - 0.055 13.3 17.8 0.071 12.9 17.8 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RICTOR_N PF14664.6 CDI81239.1 - 0.061 12.3 7.1 1.3 7.9 7.1 2.2 1 1 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term SARG PF15385.6 CDI81239.1 - 0.069 12.4 24.0 0.089 12.0 24.0 1.1 1 0 0 1 1 1 0 Specifically androgen-regulated gene protein Presenilin PF01080.17 CDI81239.1 - 0.072 11.8 16.6 0.085 11.6 16.6 1.2 1 0 0 1 1 1 0 Presenilin SAMP PF05924.11 CDI81239.1 - 0.095 12.0 7.3 4.8 6.6 0.1 3.5 3 0 0 3 3 3 0 SAMP Motif SLC12 PF03522.15 CDI81239.1 - 0.14 11.2 18.8 0.17 10.9 18.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 CDI81239.1 - 0.18 11.8 15.1 0.31 11.0 15.1 1.4 1 0 0 1 1 1 0 Protein Family FAM60A DUF3292 PF11696.8 CDI81239.1 - 0.27 9.6 14.0 0.31 9.4 14.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Lin-8 PF03353.15 CDI81239.1 - 0.3 10.6 18.9 0.42 10.1 18.9 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Spc7_N PF15402.6 CDI81239.1 - 0.58 8.3 15.0 0.91 7.7 15.0 1.2 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 ALMT PF11744.8 CDI81239.1 - 0.99 8.2 11.5 1.1 8.0 11.5 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 CDI81239.1 - 1 9.4 24.7 1.4 8.9 24.4 1.4 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2126 PF09899.9 CDI81239.1 - 1.1 7.2 11.9 1.5 6.8 11.9 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CSG2 PF16965.5 CDI81239.1 - 1.1 8.1 8.0 1.7 7.5 8.0 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator Pox_Ag35 PF03286.14 CDI81239.1 - 1.3 8.8 14.7 2 8.2 14.7 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Ndc1_Nup PF09531.10 CDI81239.1 - 1.4 7.6 21.1 1.8 7.2 21.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PGA2 PF07543.12 CDI81239.1 - 1.5 8.8 17.4 2.9 7.9 17.4 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 eIF-3_zeta PF05091.12 CDI81239.1 - 1.6 7.7 20.3 2.1 7.2 20.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Serinc PF03348.15 CDI81239.1 - 1.8 7.4 7.6 2.8 6.8 7.6 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2828 PF11443.8 CDI81239.1 - 2 6.4 16.6 2.8 5.9 16.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SID-1_RNA_chan PF13965.6 CDI81239.1 - 2.3 6.5 6.7 3.1 6.1 6.7 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4011 PF13195.6 CDI81239.1 - 3 7.7 9.9 6 6.8 9.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) HCO3_cotransp PF00955.21 CDI81239.1 - 3.9 6.2 7.5 5.1 5.8 7.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family Paf1 PF03985.13 CDI81239.1 - 5.1 6.0 24.3 6.7 5.6 24.3 1.1 1 0 0 1 1 1 0 Paf1 TRAP_alpha PF03896.16 CDI81239.1 - 5.2 6.2 13.4 2.6 7.2 11.2 1.7 1 1 1 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit O-antigen_lig PF13425.6 CDI81239.1 - 5.2 5.7 8.4 6.4 5.5 8.4 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Membralin PF09746.9 CDI81239.1 - 7.6 5.5 11.2 10 5.1 11.2 1.3 1 0 0 1 1 1 0 Tumour-associated protein Cellulose_synt PF03552.14 CDI81239.1 - 9.7 4.5 5.5 12 4.2 5.5 1.2 1 0 0 1 1 1 0 Cellulose synthase V_ATPase_I PF01496.19 CDI81245.1 - 0.00093 17.3 8.3 0.00093 17.3 8.3 12.1 8 2 2 12 12 12 2 V-type ATPase 116kDa subunit family DUF4834 PF16118.5 CDI81246.1 - 0.0001 23.2 0.4 0.0001 23.2 0.4 5.6 2 1 2 5 5 4 1 Domain of unknown function (DUF4834) RskA PF10099.9 CDI81246.1 - 0.00031 21.1 18.9 0.037 14.3 8.4 2.5 2 1 0 2 2 2 2 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI81246.1 - 0.0015 18.2 19.8 0.0015 18.2 19.8 2.9 2 1 0 2 2 1 1 Spt20 family TRAP_alpha PF03896.16 CDI81246.1 - 0.0076 15.5 0.8 0.0076 15.5 0.8 2.8 2 1 1 3 3 3 1 Translocon-associated protein (TRAP), alpha subunit Peptidase_S49_N PF08496.10 CDI81246.1 - 0.0099 16.0 13.5 0.22 11.6 2.1 2.9 3 0 0 3 3 3 2 Peptidase family S49 N-terminal FliD_N PF02465.18 CDI81246.1 - 0.027 15.2 8.5 0.027 15.2 8.5 4.6 2 1 0 2 2 1 0 Flagellar hook-associated protein 2 N-terminus SARAF PF06682.12 CDI81246.1 - 0.034 13.8 0.1 0.034 13.8 0.1 4.7 2 1 1 4 4 3 0 SOCE-associated regulatory factor of calcium homoeostasis GBP_C PF02841.14 CDI81246.1 - 0.42 10.0 26.1 0.51 9.7 13.0 2.2 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain Endonuc_Holl PF10107.9 CDI81246.1 - 0.56 10.0 7.4 0.2 11.5 0.5 2.5 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase DUF4446 PF14584.6 CDI81246.1 - 1.5 8.8 15.2 0.048 13.7 1.9 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) XhlA PF10779.9 CDI81246.1 - 6.6 7.0 10.0 0.061 13.5 2.0 1.8 2 0 0 2 2 1 0 Haemolysin XhlA SARAF PF06682.12 CDI81247.1 - 0.0075 16.0 12.3 0.0074 16.0 12.3 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis RskA PF10099.9 CDI81247.1 - 0.019 15.3 28.7 0.031 14.6 28.7 1.5 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Zea_mays_MuDR PF05928.11 CDI81247.1 - 0.021 14.5 7.7 0.025 14.2 7.7 1.1 1 0 0 1 1 1 0 Zea mays MURB-like protein (MuDR) DUF2232 PF09991.9 CDI81247.1 - 0.14 11.3 1.8 0.16 11.1 1.8 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) SprA-related PF12118.8 CDI81247.1 - 0.31 10.1 40.9 0.39 9.8 40.9 1.1 1 0 0 1 1 1 0 SprA-related family DUF4746 PF15928.5 CDI81247.1 - 0.34 10.3 11.6 0.32 10.4 11.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SID-1_RNA_chan PF13965.6 CDI81247.1 - 0.34 9.3 5.9 0.36 9.2 5.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 eIF-3_zeta PF05091.12 CDI81247.1 - 0.73 8.7 20.0 0.77 8.7 20.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MAJIN PF15077.6 CDI81247.1 - 1.3 8.8 14.3 1.3 8.7 14.3 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF1387 PF07139.11 CDI81247.1 - 2 8.1 19.5 2.1 8.0 19.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Neur_chan_memb PF02932.16 CDI81247.1 - 2 8.4 15.7 2.2 8.3 15.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Endostatin PF06482.11 CDI81247.1 - 2.2 7.7 18.8 2.2 7.7 18.8 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Serinc PF03348.15 CDI81247.1 - 2.3 7.0 11.2 2.8 6.8 11.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DcuA_DcuB PF03605.14 CDI81247.1 - 3.2 6.5 15.3 0.22 10.4 10.2 1.5 1 1 1 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter RR_TM4-6 PF06459.12 CDI81247.1 - 3.8 7.3 19.5 4.3 7.1 19.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MDM10 PF12519.8 CDI81247.1 - 4.9 5.9 13.4 4.6 6.0 13.4 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 ALMT PF11744.8 CDI81247.1 - 4.9 5.9 19.3 5.3 5.7 19.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter HCO3_cotransp PF00955.21 CDI81247.1 - 5.5 5.7 6.1 5.5 5.7 6.1 1.1 1 0 0 1 1 1 0 HCO3- transporter family SLC12 PF03522.15 CDI81247.1 - 6.5 5.7 19.4 6.6 5.6 19.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 FPN1 PF06963.12 CDI81247.1 - 7.8 4.9 11.7 15 4.0 11.7 1.5 1 1 0 1 1 1 0 Ferroportin1 (FPN1) Hid1 PF12722.7 CDI81247.1 - 8.5 4.4 19.8 8.1 4.4 19.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CSG2 PF16965.5 CDI81247.1 - 8.7 5.2 7.3 10 5.0 7.3 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator Efg1 PF10153.9 CDI81249.1 - 0.1 13.0 16.4 0.13 12.6 16.4 1.2 1 0 0 1 1 1 0 rRNA-processing protein Efg1 UPF0240 PF06784.11 CDI81249.1 - 0.15 12.1 11.3 0.18 11.8 11.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) DDHD PF02862.17 CDI81249.1 - 0.45 10.6 15.0 0.52 10.4 15.0 1.0 1 0 0 1 1 1 0 DDHD domain V_ATPase_I PF01496.19 CDI81249.1 - 0.56 8.1 18.0 0.58 8.0 18.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 CDI81249.1 - 1 8.9 22.8 1.1 8.8 22.8 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit CENP-H PF05837.12 CDI81249.1 - 2.1 8.8 22.8 2.6 8.5 22.8 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Presenilin PF01080.17 CDI81249.1 - 5.6 5.6 18.8 6.2 5.5 18.8 1.0 1 0 0 1 1 1 0 Presenilin AAA_23 PF13476.6 CDI81249.1 - 8.5 6.8 23.0 12 6.4 23.0 1.2 1 0 0 1 1 1 0 AAA domain DUF4179 PF13786.6 CDI81254.1 - 0.0026 18.2 0.1 0.17 12.4 0.0 3.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4179) RskA PF10099.9 CDI81254.1 - 0.0036 17.6 17.7 0.42 10.9 17.7 2.9 1 1 0 1 1 1 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI81254.1 - 0.005 16.5 14.4 0.005 16.5 14.4 2.3 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein Caskin1-CID PF16600.5 CDI81254.1 - 0.032 14.8 2.8 0.032 14.8 2.8 2.2 2 0 0 2 2 2 0 Caskin1 CASK-interaction domain SID-1_RNA_chan PF13965.6 CDI81254.1 - 0.38 9.1 3.9 0.37 9.1 3.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Raftlin PF15250.6 CDI81254.1 - 1.3 7.7 21.2 0.84 8.3 20.1 1.3 1 1 0 1 1 1 0 Raftlin Robl_LC7 PF03259.17 CDI81254.1 - 7.5 6.4 7.4 1.7 8.5 0.4 2.7 3 0 0 3 3 3 0 Roadblock/LC7 domain LptC PF06835.13 CDI81266.1 - 0.31 10.6 5.8 0.39 10.3 5.8 1.0 1 0 0 1 1 1 0 Lipopolysaccharide-assembly, LptC-related HNF-1_N PF04814.13 CDI81266.1 - 2 9.0 9.6 2.2 8.8 9.6 1.0 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus TMEM154 PF15102.6 CDI81266.1 - 3.8 7.4 10.4 4 7.3 10.4 1.1 1 0 0 1 1 1 0 TMEM154 protein family DUF755 PF05501.11 CDI81276.1 - 0.19 12.0 10.9 0.61 10.4 10.9 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF89 PF01937.19 CDI81282.1 - 6e-16 58.3 0.6 1.1e-14 54.2 0.6 2.0 1 1 0 1 1 1 1 Protein of unknown function DUF89 Spt20 PF12090.8 CDI81282.1 - 0.00039 20.1 19.7 0.00051 19.7 19.7 1.1 1 0 0 1 1 1 1 Spt20 family Ndc1_Nup PF09531.10 CDI81282.1 - 0.0018 17.1 4.6 0.002 16.9 4.6 1.1 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup SpoIIIAH PF12685.7 CDI81282.1 - 0.002 18.0 3.4 0.0023 17.8 3.4 1.1 1 0 0 1 1 1 1 SpoIIIAH-like protein TFIIA PF03153.13 CDI81282.1 - 0.0028 17.7 14.0 0.0034 17.4 14.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Med3 PF11593.8 CDI81282.1 - 0.0029 16.9 8.8 0.0047 16.2 8.8 1.3 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Apt1 PF10351.9 CDI81282.1 - 0.0073 15.2 9.6 0.0083 15.0 9.6 1.0 1 0 0 1 1 1 1 Golgi-body localisation protein domain DUF908 PF06012.12 CDI81282.1 - 0.027 13.9 7.8 0.034 13.6 7.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Macoilin PF09726.9 CDI81282.1 - 0.032 12.8 14.9 0.04 12.5 14.9 1.0 1 0 0 1 1 1 0 Macoilin family DUF4175 PF13779.6 CDI81282.1 - 0.074 10.9 7.4 0.078 10.9 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4518 PF15008.6 CDI81282.1 - 0.099 11.8 7.1 0.13 11.4 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) ALMT PF11744.8 CDI81282.1 - 0.13 11.1 1.4 0.15 10.9 1.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter MACPF PF01823.19 CDI81282.1 - 0.18 11.9 8.9 0.29 11.2 8.9 1.3 1 0 0 1 1 1 0 MAC/Perforin domain Lin-8 PF03353.15 CDI81282.1 - 0.29 10.7 11.1 0.39 10.2 11.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SSP160 PF06933.11 CDI81282.1 - 0.32 9.1 11.6 0.35 9.0 11.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3452 PF11934.8 CDI81282.1 - 0.4 10.2 9.4 3.4 7.2 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3452) SPX PF03105.19 CDI81282.1 - 0.43 10.4 14.4 0.52 10.2 14.4 1.1 1 0 0 1 1 1 0 SPX domain Joubert PF15392.6 CDI81282.1 - 0.49 10.1 11.6 0.65 9.7 11.6 1.1 1 0 0 1 1 1 0 Joubert syndrome-associated Cwf_Cwc_15 PF04889.12 CDI81282.1 - 0.56 9.9 8.5 0.75 9.5 8.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PAP1 PF08601.10 CDI81282.1 - 0.56 9.9 18.8 0.74 9.5 18.8 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Sporozoite_P67 PF05642.11 CDI81282.1 - 0.69 7.9 7.7 1 7.4 7.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen GTA_holin_3TM PF11351.8 CDI81282.1 - 0.78 10.3 5.2 1.2 9.6 5.2 1.2 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release GREB1 PF15782.5 CDI81282.1 - 0.79 6.8 9.6 0.95 6.5 9.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FAM70 PF14967.6 CDI81282.1 - 1 8.7 7.8 1.4 8.3 7.8 1.2 1 0 0 1 1 1 0 FAM70 protein Presenilin PF01080.17 CDI81282.1 - 1.2 7.8 11.4 1.8 7.3 11.4 1.2 1 0 0 1 1 1 0 Presenilin Peroxin-3 PF04882.12 CDI81282.1 - 2 7.3 13.1 2.6 6.9 13.1 1.1 1 0 0 1 1 1 0 Peroxin-3 Peptidase_S64 PF08192.11 CDI81282.1 - 2.5 6.5 13.1 3.2 6.1 13.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Secretin_N_2 PF07655.13 CDI81282.1 - 3.4 8.3 25.5 0.35 11.4 18.0 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Spc7_N PF15402.6 CDI81282.1 - 3.7 5.7 15.7 4.7 5.3 15.7 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 RAP1 PF07218.11 CDI81282.1 - 4.8 5.3 14.3 6 5.0 14.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Herpes_pp85 PF04637.12 CDI81282.1 - 4.9 5.5 7.5 6.6 5.0 7.5 1.3 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Glycos_transf_2 PF00535.26 CDI81285.1 - 2.8e-24 85.8 0.0 3.8e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDI81285.1 - 8.6e-11 42.2 0.0 1.4e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 CDI81285.1 - 1.2e-09 37.7 0.3 3.9e-09 36.0 0.2 1.8 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 CDI81285.1 - 0.0035 16.8 0.0 0.0068 15.9 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CDI81285.1 - 0.0043 16.6 0.0 0.013 15.0 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 21 Pex14_N PF04695.13 CDI81286.1 - 0.0072 17.0 28.1 0.0091 16.7 28.1 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Shadoo PF14999.6 CDI81286.1 - 0.0088 16.1 3.3 0.0088 16.1 3.3 1.4 2 0 0 2 2 1 1 Shadow of prion protein, neuroprotective BAF1_ABF1 PF04684.13 CDI81286.1 - 0.14 11.2 18.7 0.17 10.9 18.7 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Mit_KHE1 PF10173.9 CDI81286.1 - 0.14 12.3 6.5 0.14 12.2 6.5 1.1 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related DUF4407 PF14362.6 CDI81286.1 - 0.14 11.5 32.6 0.18 11.1 32.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PTPRCAP PF15713.5 CDI81286.1 - 0.15 12.3 19.3 0.18 12.1 19.3 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Endostatin PF06482.11 CDI81286.1 - 0.29 10.6 18.6 0.32 10.4 18.6 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin BORG_CEP PF14957.6 CDI81286.1 - 0.31 12.2 11.7 0.36 12.0 11.7 1.1 1 0 0 1 1 1 0 Cdc42 effector DUF913 PF06025.12 CDI81286.1 - 0.32 9.9 11.9 0.34 9.8 11.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3984 PF13136.6 CDI81286.1 - 0.34 10.3 16.5 0.41 10.0 16.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) RPN2_C PF18004.1 CDI81286.1 - 0.37 10.7 17.2 0.44 10.4 17.2 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Cellulose_synt PF03552.14 CDI81286.1 - 0.62 8.5 6.7 0.62 8.5 6.7 1.0 1 0 0 1 1 1 0 Cellulose synthase Peptidase_S49_N PF08496.10 CDI81286.1 - 0.66 10.0 15.9 0.91 9.6 15.9 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SID-1_RNA_chan PF13965.6 CDI81286.1 - 0.71 8.2 7.4 0.74 8.2 7.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NEMP PF10225.9 CDI81286.1 - 0.75 9.4 6.0 0.92 9.1 6.0 1.1 1 0 0 1 1 1 0 NEMP family eIF-3_zeta PF05091.12 CDI81286.1 - 0.81 8.6 24.7 0.92 8.4 24.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CLN3 PF02487.17 CDI81286.1 - 0.89 8.5 12.8 0.88 8.5 12.8 1.1 1 0 0 1 1 1 0 CLN3 protein SARAF PF06682.12 CDI81286.1 - 0.98 9.0 15.4 1.1 8.8 15.4 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis MMU163 PF17119.5 CDI81286.1 - 1 8.5 8.9 1.3 8.2 8.9 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis FAM60A PF15396.6 CDI81286.1 - 1.1 9.3 16.3 1.2 9.1 16.3 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Lin-8 PF03353.15 CDI81286.1 - 1.1 8.8 21.5 1.2 8.7 21.5 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Membralin PF09746.9 CDI81286.1 - 1.2 8.1 11.9 1.3 8.0 11.9 1.0 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 CDI81286.1 - 1.3 7.7 25.7 1.5 7.5 25.7 1.0 1 0 0 1 1 1 0 Presenilin Velvet PF11754.8 CDI81286.1 - 1.4 8.8 17.8 1.7 8.6 17.8 1.1 1 0 0 1 1 1 0 Velvet factor DUF572 PF04502.13 CDI81286.1 - 1.5 8.4 18.3 1.6 8.2 18.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) PAT1 PF09770.9 CDI81286.1 - 1.6 6.9 35.3 1.9 6.7 35.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SpoIIP PF07454.11 CDI81286.1 - 1.6 8.1 20.0 2 7.8 20.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SLC12 PF03522.15 CDI81286.1 - 1.8 7.5 20.4 2 7.4 20.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 IHABP4_N PF16174.5 CDI81286.1 - 1.9 9.1 27.8 2.3 8.8 27.8 1.1 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Zip PF02535.22 CDI81286.1 - 2 7.6 10.2 2.2 7.4 10.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Tim54 PF11711.8 CDI81286.1 - 2 7.1 15.7 2.1 7.1 15.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4050 PF13259.6 CDI81286.1 - 2.1 8.6 16.2 2.1 8.6 16.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Band_3_cyto PF07565.13 CDI81286.1 - 2.1 8.1 18.3 2.3 7.9 18.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CDC45 PF02724.14 CDI81286.1 - 2.1 6.5 15.8 2.2 6.5 15.8 1.0 1 0 0 1 1 1 0 CDC45-like protein PPL5 PF18168.1 CDI81286.1 - 2.2 7.5 14.0 2.4 7.3 14.0 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Neur_chan_memb PF02932.16 CDI81286.1 - 2.3 8.2 15.7 2.5 8.1 15.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PA26 PF04636.13 CDI81286.1 - 2.3 7.1 14.7 2.6 6.9 14.7 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) STAC2_u1 PF16664.5 CDI81286.1 - 2.3 8.7 13.0 3 8.3 13.0 1.2 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 RR_TM4-6 PF06459.12 CDI81286.1 - 2.4 7.9 21.7 2.6 7.8 21.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Connexin PF00029.19 CDI81286.1 - 2.4 7.9 15.2 2.9 7.6 15.2 1.2 1 0 0 1 1 1 0 Connexin TFIIA PF03153.13 CDI81286.1 - 2.6 7.9 50.9 4 7.3 50.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDK5_activator PF03261.15 CDI81286.1 - 2.7 7.5 15.2 3 7.3 15.2 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein HCO3_cotransp PF00955.21 CDI81286.1 - 2.8 6.7 7.4 2.7 6.7 7.4 1.0 1 0 0 1 1 1 0 HCO3- transporter family NPR3 PF03666.13 CDI81286.1 - 2.9 6.6 18.9 3.3 6.4 18.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Bac_luciferase PF00296.20 CDI81286.1 - 3 7.2 14.9 3.3 7.0 14.9 1.0 1 0 0 1 1 1 0 Luciferase-like monooxygenase Serinc PF03348.15 CDI81286.1 - 3.1 6.6 12.4 3.4 6.5 12.4 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) YABBY PF04690.13 CDI81286.1 - 3.1 8.3 14.0 3.7 8.1 14.0 1.2 1 0 0 1 1 1 0 YABBY protein ALMT PF11744.8 CDI81286.1 - 3.5 6.4 15.0 3.6 6.3 15.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Paf1 PF03985.13 CDI81286.1 - 4.4 6.2 21.5 5 6.0 21.5 1.1 1 0 0 1 1 1 0 Paf1 HAUS6_N PF14661.6 CDI81286.1 - 4.5 6.8 25.2 4.9 6.7 25.2 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF2370 PF10176.9 CDI81286.1 - 4.8 6.7 12.9 6 6.4 12.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF3523 PF12037.8 CDI81286.1 - 5 6.4 34.7 6 6.2 34.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) CCSAP PF15748.5 CDI81286.1 - 5.2 7.2 24.1 6.1 6.9 24.1 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Smg8_Smg9 PF10220.9 CDI81286.1 - 5.5 5.2 21.9 6 5.0 21.9 1.0 1 0 0 1 1 1 0 Smg8_Smg9 DDHD PF02862.17 CDI81286.1 - 5.7 7.0 19.0 7.3 6.7 19.0 1.2 1 0 0 1 1 1 0 DDHD domain Paramyxo_ncap PF00973.19 CDI81286.1 - 5.7 5.7 16.5 6.2 5.6 16.5 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein MDM10 PF12519.8 CDI81286.1 - 5.7 5.7 17.1 6.2 5.6 17.1 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 O-antigen_lig PF13425.6 CDI81286.1 - 6 5.5 10.0 6.2 5.5 10.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein MAJIN PF15077.6 CDI81286.1 - 6 6.6 16.0 6.9 6.4 16.0 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF2126 PF09899.9 CDI81286.1 - 6.1 4.8 14.7 6.4 4.7 14.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Sec62 PF03839.16 CDI81286.1 - 6.4 6.2 16.8 7.4 6.0 16.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DDRGK PF09756.9 CDI81286.1 - 6.7 6.2 28.3 8.8 5.9 28.3 1.1 1 0 0 1 1 1 0 DDRGK domain PIEZO PF15917.5 CDI81286.1 - 7 6.1 25.5 8.4 5.8 25.5 1.0 1 0 0 1 1 1 0 Piezo DUF3332 PF11810.8 CDI81286.1 - 7.3 6.2 9.0 8.2 6.0 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) Mem_trans PF03547.18 CDI81286.1 - 8.8 4.6 7.1 9.4 4.5 7.1 1.1 1 0 0 1 1 1 0 Membrane transport protein CSG2 PF16965.5 CDI81286.1 - 9.7 5.0 13.6 12 4.8 13.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator MMR1 PF08505.10 CDI81286.1 - 9.7 6.4 23.1 13 5.9 23.1 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein CBFNT PF08143.11 CDI81288.1 - 4.5 8.8 20.5 5 8.6 19.5 1.6 1 1 0 1 1 1 0 CBFNT (NUC161) domain RskA PF10099.9 CDI81288.1 - 7.9 6.7 21.1 26 5.0 21.1 1.9 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Sporozoite_P67 PF05642.11 CDI81294.1 - 0.012 13.8 16.9 0.017 13.3 16.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CENP-B_dimeris PF09026.10 CDI81294.1 - 0.18 12.2 11.3 0.38 11.2 11.3 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Spt20 PF12090.8 CDI81294.1 - 0.35 10.4 4.1 0.44 10.1 4.1 1.1 1 0 0 1 1 1 0 Spt20 family NOA36 PF06524.12 CDI81294.1 - 0.46 9.8 7.3 0.86 8.9 7.3 1.4 1 0 0 1 1 1 0 NOA36 protein SUIM_assoc PF16619.5 CDI81294.1 - 0.73 9.9 12.6 1.7 8.8 12.6 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DNA_pol_phi PF04931.13 CDI81294.1 - 1.9 6.5 4.3 3.5 5.6 4.3 1.4 1 0 0 1 1 1 0 DNA polymerase phi O-antigen_lig PF13425.6 CDI81296.1 - 0.57 8.9 23.6 0.69 8.6 23.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SID-1_RNA_chan PF13965.6 CDI81296.1 - 0.65 8.3 23.5 1 7.7 23.5 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF572 PF04502.13 CDI81296.1 - 0.96 9.0 41.9 1.6 8.3 41.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Cpn10 PF00166.21 CDI81297.1 - 7.8e-28 96.4 0.4 3.1e-18 65.6 0.0 3.2 3 0 0 3 3 3 2 Chaperonin 10 Kd subunit SR-25 PF10500.9 CDI81297.1 - 0.082 12.5 5.0 0.11 12.1 5.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1180 PF06679.12 CDI81297.1 - 1.2 9.6 9.0 0.43 11.0 4.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Otopetrin PF03189.13 CDI81298.1 - 0.0075 15.1 1.9 0.0075 15.1 1.9 2.1 1 1 1 2 2 2 1 Otopetrin CRPA PF05745.11 CDI81298.1 - 0.093 12.7 0.3 0.38 10.7 0.3 2.0 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Phage_holin_5_2 PF16079.5 CDI81298.1 - 0.16 12.3 0.8 0.5 10.7 0.0 2.2 2 0 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V Hid1 PF12722.7 CDI81298.1 - 1.9 6.5 16.3 3 5.9 16.3 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 CDI81298.1 - 2.2 8.3 6.3 4 7.4 5.6 1.6 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3290 PF11694.8 CDI81298.1 - 2.4 8.1 4.4 2 8.4 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) Hamartin PF04388.12 CDI81298.1 - 8.8 4.8 18.9 12 4.4 18.9 1.3 1 0 0 1 1 1 0 Hamartin protein Helicase_C_2 PF13307.6 CDI81300.1 - 6.5e-16 59.0 0.0 7.6e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Helicase C-terminal domain PIH1_CS PF18201.1 CDI81305.1 - 1.2e-06 28.8 0.1 4.8e-06 26.9 0.0 2.1 2 1 0 2 2 2 1 PIH1 CS-like domain SMN PF06003.12 CDI81305.1 - 0.0063 15.8 0.5 0.0081 15.5 0.5 1.2 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Rsc14 PF08586.10 CDI81305.1 - 0.026 15.3 0.7 0.041 14.7 0.7 1.3 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit Spt20 PF12090.8 CDI81305.1 - 0.072 12.7 6.8 0.09 12.4 6.8 1.1 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 CDI81305.1 - 0.24 10.3 5.4 0.25 10.2 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Androgen_recep PF02166.16 CDI81305.1 - 4.3 6.1 6.9 5.4 5.7 6.9 1.1 1 0 0 1 1 1 0 Androgen receptor SUIM_assoc PF16619.5 CDI81305.1 - 8.1 6.6 15.0 16 5.7 15.0 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF2967 PF11179.8 CDI81305.1 - 9.7 4.1 7.7 13 3.8 7.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Slu7 PF11708.8 CDI81324.1 - 0.022 14.5 45.7 0.16 11.7 26.5 2.4 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor CLN3 PF02487.17 CDI81324.1 - 0.12 11.4 32.5 0.03 13.4 12.1 2.2 2 0 0 2 2 2 0 CLN3 protein SID-1_RNA_chan PF13965.6 CDI81324.1 - 1.2 7.5 22.9 0.013 13.9 7.7 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 SR-25 PF10500.9 CDI81326.1 - 0.0013 18.4 18.6 0.0013 18.4 18.6 2.1 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI81326.1 - 0.12 12.3 25.4 0.16 12.0 25.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Auxin_canalis PF05703.11 CDI81326.1 - 0.18 11.7 30.9 3.9 7.3 30.9 2.0 1 1 0 1 1 1 0 Auxin canalisation TCP PF03634.13 CDI81326.1 - 0.71 10.4 23.3 0.064 13.8 13.1 2.1 2 0 0 2 2 2 0 TCP family transcription factor WBS_methylT PF12589.8 CDI81326.1 - 0.91 10.3 6.5 2.1 9.1 6.5 1.7 1 1 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome DUF4473 PF14747.6 CDI81326.1 - 5.7 7.6 11.2 0.14 12.7 1.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) CCDC106 PF15794.5 CDI81326.1 - 6.2 6.5 20.8 0.91 9.2 11.8 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Secretin_N_2 PF07655.13 CDI81326.1 - 7.8 7.1 30.8 6.4 7.4 15.4 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain PRP1_N PF06424.12 CDI81333.1 - 0.043 14.2 15.4 0.43 11.0 9.2 2.2 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal DUF1907 PF08925.11 CDI81333.1 - 1.4 8.3 7.1 0.063 12.7 1.7 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1907) DUF533 PF04391.12 CDI81333.1 - 3.2 7.3 25.5 1.5 8.4 12.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF533) RR_TM4-6 PF06459.12 CDI81333.1 - 4.5 7.0 18.4 2 8.2 10.4 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 CDI81338.1 - 0.12 11.6 8.7 0.066 12.4 1.7 3.0 3 0 0 3 3 3 0 ZIP Zinc transporter Presenilin PF01080.17 CDI81338.1 - 0.25 10.1 40.6 0.62 8.8 2.8 3.3 3 0 0 3 3 3 0 Presenilin Connexin PF00029.19 CDI81338.1 - 0.4 10.4 27.7 0.02 14.7 5.6 3.9 3 1 0 3 3 3 0 Connexin FAM176 PF14851.6 CDI81338.1 - 1.6 8.3 23.3 0.87 9.2 9.6 4.0 4 0 0 4 4 4 0 FAM176 family PPP4R2 PF09184.11 CDI81338.1 - 4.5 6.8 14.2 8.3 5.9 9.4 2.8 3 0 0 3 3 3 0 PPP4R2 RR_TM4-6 PF06459.12 CDI81346.1 - 0.1 12.4 15.8 0.12 12.2 15.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 CDI81346.1 - 0.16 10.3 18.8 0.18 10.0 18.8 1.0 1 0 0 1 1 1 0 CDC45-like protein CCDC106 PF15794.5 CDI81346.1 - 0.16 11.7 19.0 0.21 11.3 19.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 GAGA_bind PF06217.12 CDI81346.1 - 0.49 10.6 14.0 0.61 10.3 14.0 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family EOS1 PF12326.8 CDI81346.1 - 0.63 10.0 6.8 0.83 9.6 6.8 1.2 1 0 0 1 1 1 0 N-glycosylation protein MID_MedPIWI PF18296.1 CDI81346.1 - 1 9.1 9.7 1.2 8.9 9.7 1.1 1 0 0 1 1 1 0 MID domain of medPIWI Nucleo_P87 PF07267.11 CDI81346.1 - 1.4 7.7 14.8 1.6 7.5 14.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Med19 PF10278.9 CDI81346.1 - 1.7 8.5 32.1 0.36 10.8 28.5 1.6 1 1 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF913 PF06025.12 CDI81346.1 - 1.8 7.4 8.2 2 7.3 8.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Vfa1 PF08432.10 CDI81346.1 - 2.6 8.3 26.6 1.3 9.3 24.6 1.5 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 AAA_11 PF13086.6 CDI81346.1 - 3.2 7.5 13.8 4.1 7.1 13.8 1.2 1 0 0 1 1 1 0 AAA domain FGF-BP1 PF06473.12 CDI81346.1 - 5.3 6.8 22.2 9.5 6.0 22.2 1.3 1 1 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) SprA-related PF12118.8 CDI81346.1 - 7 5.7 18.5 8.5 5.4 18.5 1.1 1 0 0 1 1 1 0 SprA-related family SR-25 PF10500.9 CDI81346.1 - 7.7 6.1 39.0 13 5.3 39.0 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Neur_chan_memb PF02932.16 CDI81346.1 - 8.1 6.4 10.6 9.5 6.2 10.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Lipase_3 PF01764.25 CDI81349.1 - 9.1e-12 45.0 0.0 1.6e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Voldacs PF03517.13 CDI81350.1 - 8.9e-18 64.8 2.8 8.1e-16 58.4 2.6 2.4 2 1 0 2 2 2 1 Regulator of volume decrease after cellular swelling RMI1_N PF08585.12 CDI81351.1 - 2.1e-13 50.6 0.0 2.5e-12 47.0 0.0 2.1 1 1 0 1 1 1 1 RecQ mediated genome instability protein Coatomer_WDAD PF04053.14 CDI81352.1 - 5.3e-06 25.8 0.4 0.0049 16.0 0.2 3.3 3 0 0 3 3 3 2 Coatomer WD associated region ubiquitin PF00240.23 CDI81354.1 - 8.7e-05 22.2 0.0 0.00019 21.1 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin family DUF4131 PF13567.6 CDI81354.1 - 0.095 12.3 3.3 0.15 11.7 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Fe_hyd_SSU PF02256.17 CDI81356.1 - 0.17 12.0 0.0 3.2 7.9 0.0 3.3 2 0 0 2 2 2 0 Iron hydrogenase small subunit AhpC-TSA PF00578.21 CDI81357.1 - 5.9e-29 100.5 0.0 7.2e-29 100.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDI81357.1 - 5.9e-12 45.5 0.0 7.2e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CDI81357.1 - 5.6e-09 35.7 0.1 1e-08 34.9 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA_2 PF13911.6 CDI81357.1 - 0.037 14.2 0.0 0.05 13.7 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme GSHPx PF00255.19 CDI81357.1 - 0.085 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Glutathione peroxidase YfdX PF10938.8 CDI81358.1 - 0.063 13.2 0.1 0.063 13.2 0.1 2.0 3 0 0 3 3 3 0 YfdX protein SET PF00856.28 CDI81359.1 - 2.3e-06 28.1 0.0 1.5e-05 25.4 0.0 2.2 1 1 0 1 1 1 1 SET domain ADK PF00406.22 CDI81360.1 - 8.8e-31 107.1 0.0 2.3e-20 73.2 0.0 2.0 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 CDI81360.1 - 9.7e-15 55.2 0.0 6.6e-14 52.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CDI81360.1 - 0.00033 20.8 0.0 0.0047 17.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDI81360.1 - 0.00047 20.7 0.0 0.0027 18.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 CDI81360.1 - 0.0016 18.2 0.0 0.0026 17.5 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase ADK_lid PF05191.14 CDI81360.1 - 0.0094 15.9 0.1 0.027 14.4 0.1 1.9 1 1 0 1 1 1 1 Adenylate kinase, active site lid AAA PF00004.29 CDI81360.1 - 0.044 14.2 0.0 0.091 13.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CDI81360.1 - 0.058 13.8 0.0 11 6.5 0.0 2.4 2 0 0 2 2 2 0 RNA helicase Rad17 PF03215.15 CDI81360.1 - 0.099 12.6 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain NACHT PF05729.12 CDI81360.1 - 0.19 11.6 0.6 17 5.3 0.1 2.3 2 0 0 2 2 2 0 NACHT domain Ribosomal_60s PF00428.19 CDI81361.1 - 3.2 8.4 6.8 0.61 10.7 0.8 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein PDEase_I PF00233.19 CDI81363.1 - 2e-59 201.2 0.3 9.3e-57 192.5 0.0 2.8 2 1 1 3 3 3 2 3'5'-cyclic nucleotide phosphodiesterase Rab15_effector PF15208.6 CDI81363.1 - 0.016 14.5 0.1 0.031 13.6 0.1 1.3 1 0 0 1 1 1 0 Rab15 effector Peptidase_U4 PF03419.13 CDI81363.1 - 1.4 8.2 9.4 0.025 13.9 1.5 1.9 2 0 0 2 2 2 0 Sporulation factor SpoIIGA TFIIA PF03153.13 CDI81363.1 - 10 6.0 34.1 0.045 13.8 10.1 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI81371.1 - 0.037 13.0 10.6 0.056 12.4 10.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI81371.1 - 0.14 11.7 19.5 0.21 11.2 19.5 1.2 1 0 0 1 1 1 0 Spt20 family Sporozoite_P67 PF05642.11 CDI81371.1 - 0.23 9.5 18.7 0.29 9.2 18.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Folliculin PF11704.8 CDI81371.1 - 1.2 9.0 6.7 1.8 8.4 6.7 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF4834 PF16118.5 CDI81371.1 - 1.6 9.7 5.9 2.6 9.1 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) GREB1 PF15782.5 CDI81371.1 - 1.7 5.7 7.2 1.5 5.8 7.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer THOC2_N PF16134.5 CDI81371.1 - 2.7 6.5 10.2 4.5 5.8 10.2 1.3 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Roughex PF06020.11 CDI81371.1 - 8.1 5.4 11.4 14 4.7 11.4 1.4 1 0 0 1 1 1 0 Drosophila roughex protein CE2_N PF17996.1 CDI81372.1 - 0.032 14.2 0.1 0.043 13.8 0.1 1.2 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal Glt_symporter PF03616.14 CDI81372.1 - 0.052 12.2 0.7 0.056 12.1 0.7 1.0 1 0 0 1 1 1 0 Sodium/glutamate symporter DUF3767 PF12597.8 CDI81372.1 - 0.14 12.0 2.0 0.18 11.6 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) RskA PF10099.9 CDI81372.1 - 2.3 8.5 14.1 4.6 7.5 14.1 1.5 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF3675 PF12428.8 CDI81372.1 - 4 8.0 5.7 3.5 8.2 4.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3675) TFIIA PF03153.13 CDI81372.1 - 4.9 7.0 34.4 5.3 6.9 34.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI81372.1 - 8.9 6.4 10.5 9.1 6.4 10.5 1.0 1 0 0 1 1 1 0 DDHD domain Orf78 PF06024.12 CDI81373.1 - 0.0041 17.4 0.2 0.0041 17.4 0.2 9.0 9 2 0 9 9 9 1 Orf78 (ac78) SUIM_assoc PF16619.5 CDI81377.1 - 2.8e-05 24.1 6.6 0.0021 18.1 2.2 7.1 3 1 2 5 5 5 2 Unstructured region C-term to UIM in Ataxin3 Activator_LAG-3 PF11498.8 CDI81381.1 - 0.00057 19.0 65.4 0.00057 19.0 65.4 6.7 5 1 1 6 6 6 3 Transcriptional activator LAG-3 RskA PF10099.9 CDI81381.1 - 0.0062 16.9 17.8 0.0062 16.9 17.8 11.9 2 2 2 6 6 6 1 Anti-sigma-K factor rskA DUF1180 PF06679.12 CDI81383.1 - 0.68 10.3 7.0 1.4 9.4 7.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) DUF4746 PF15928.5 CDI81383.1 - 0.77 9.1 18.3 0.85 9.0 18.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Presenilin PF01080.17 CDI81383.1 - 1.3 7.7 30.0 1.3 7.7 30.0 1.0 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 CDI81383.1 - 1.5 6.6 22.9 1.8 6.4 22.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Neur_chan_memb PF02932.16 CDI81383.1 - 3.9 7.5 20.3 4 7.4 20.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Velvet PF11754.8 CDI81383.1 - 5.3 6.9 21.1 6.2 6.7 21.1 1.1 1 0 0 1 1 1 0 Velvet factor Endostatin PF06482.11 CDI81383.1 - 6.9 6.0 24.1 7.5 5.9 24.1 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin MMU163 PF17119.5 CDI81383.1 - 9.4 5.3 13.9 12 4.9 13.9 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis UPF0564 PF10595.9 CDI81392.1 - 0.003 16.7 37.3 0.0031 16.6 37.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0564 Presenilin PF01080.17 CDI81392.1 - 0.0092 14.8 29.7 0.01 14.7 29.7 1.0 1 0 0 1 1 1 1 Presenilin Pex14_N PF04695.13 CDI81392.1 - 0.026 15.2 33.5 0.042 14.5 33.5 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RPOL_N PF14700.6 CDI81392.1 - 0.11 11.8 25.3 0.13 11.7 25.3 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal SID-1_RNA_chan PF13965.6 CDI81392.1 - 0.15 10.4 10.4 0.16 10.3 10.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF572 PF04502.13 CDI81392.1 - 0.19 11.3 24.5 0.21 11.2 24.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) CLN3 PF02487.17 CDI81392.1 - 0.22 10.6 16.2 0.23 10.5 16.2 1.1 1 0 0 1 1 1 0 CLN3 protein BAF1_ABF1 PF04684.13 CDI81392.1 - 0.26 10.3 21.8 0.35 9.9 21.8 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CAC1F_C PF16885.5 CDI81392.1 - 0.3 10.7 17.2 0.34 10.5 17.2 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term FAM60A PF15396.6 CDI81392.1 - 0.31 11.0 22.2 0.37 10.8 22.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A RR_TM4-6 PF06459.12 CDI81392.1 - 0.33 10.7 29.8 0.39 10.5 29.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobT PF06213.12 CDI81392.1 - 0.34 10.3 31.9 0.45 9.9 31.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PPP4R2 PF09184.11 CDI81392.1 - 0.35 10.4 13.2 0.38 10.3 13.2 1.0 1 0 0 1 1 1 0 PPP4R2 FancD2 PF14631.6 CDI81392.1 - 0.39 8.0 14.5 0.41 8.0 14.5 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DUF4220 PF13968.6 CDI81392.1 - 0.42 10.0 3.7 0.44 9.9 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) VIR_N PF15912.5 CDI81392.1 - 0.44 10.1 15.7 0.5 9.9 15.7 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal Vfa1 PF08432.10 CDI81392.1 - 0.48 10.7 29.8 0.54 10.6 29.8 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 GNAT_acetyltr_2 PF13718.6 CDI81392.1 - 0.48 9.8 13.3 0.77 9.1 13.3 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 TFIIA PF03153.13 CDI81392.1 - 0.5 10.3 56.5 0.62 10.0 56.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BORG_CEP PF14957.6 CDI81392.1 - 0.51 11.5 16.9 0.62 11.2 16.9 1.1 1 0 0 1 1 1 0 Cdc42 effector DUF913 PF06025.12 CDI81392.1 - 0.53 9.2 16.4 0.6 9.0 16.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3295 PF11702.8 CDI81392.1 - 0.56 9.5 22.8 0.6 9.4 22.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DDHD PF02862.17 CDI81392.1 - 0.63 10.2 24.4 0.89 9.7 24.4 1.2 1 0 0 1 1 1 0 DDHD domain ADP_ribosyl_GH PF03747.14 CDI81392.1 - 0.68 9.6 6.1 0.81 9.4 6.1 1.1 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase eIF-3_zeta PF05091.12 CDI81392.1 - 0.73 8.7 33.9 0.96 8.4 33.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ctr PF04145.15 CDI81392.1 - 0.75 10.4 15.3 1.1 9.9 15.3 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Dsh_C PF12316.8 CDI81392.1 - 0.75 10.2 15.0 0.85 10.0 15.0 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal SLC12 PF03522.15 CDI81392.1 - 0.75 8.7 27.3 0.84 8.6 27.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 MCM_bind PF09739.9 CDI81392.1 - 0.95 7.8 24.0 1 7.7 24.0 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF5427 PF10310.9 CDI81392.1 - 1 8.2 29.3 1.2 8.1 29.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF2126 PF09899.9 CDI81392.1 - 1.1 7.3 16.3 1.2 7.1 16.3 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Serinc PF03348.15 CDI81392.1 - 1.1 8.1 15.0 1.6 7.5 15.0 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Endostatin PF06482.11 CDI81392.1 - 1.2 8.6 23.0 1.3 8.4 23.0 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin PIP5K PF01504.18 CDI81392.1 - 1.5 8.0 19.7 1.8 7.7 19.7 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase SAPS PF04499.15 CDI81392.1 - 1.5 7.5 19.5 1.7 7.4 19.5 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 CDI81392.1 - 1.6 7.0 28.0 1.8 6.7 28.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 CDI81392.1 - 1.7 8.6 20.4 1.9 8.5 20.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MMR1 PF08505.10 CDI81392.1 - 1.8 8.8 29.9 2.4 8.4 29.9 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Zip PF02535.22 CDI81392.1 - 2 7.6 13.9 2.3 7.4 13.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter LAP1C PF05609.12 CDI81392.1 - 2.1 7.4 27.9 2.2 7.3 27.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) O-antigen_lig PF13425.6 CDI81392.1 - 2.1 7.0 13.9 2.3 6.9 13.9 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Miga PF10265.9 CDI81392.1 - 2.2 7.1 15.9 2.5 7.0 15.9 1.0 1 0 0 1 1 1 0 Mitoguardin PPL5 PF18168.1 CDI81392.1 - 2.4 7.4 18.5 3.4 6.9 18.5 1.3 1 0 0 1 1 1 0 Prim-pol family 5 DUF4045 PF13254.6 CDI81392.1 - 2.4 7.7 25.4 2.8 7.5 25.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Velvet PF11754.8 CDI81392.1 - 2.6 7.9 23.9 3 7.7 23.9 1.1 1 0 0 1 1 1 0 Velvet factor PAT1 PF09770.9 CDI81392.1 - 2.7 6.1 41.5 3 6.0 41.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S15 PF02129.18 CDI81392.1 - 3 7.4 18.9 4.7 6.7 18.9 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DAG_kinase_N PF14513.6 CDI81392.1 - 3.2 7.9 22.2 3.6 7.8 22.2 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus CSG2 PF16965.5 CDI81392.1 - 3.6 6.5 14.3 3.9 6.3 14.3 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4569 PF15133.6 CDI81392.1 - 3.6 7.2 25.9 4.4 6.9 25.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) CCDC71L PF15374.6 CDI81392.1 - 3.7 6.7 26.8 4.3 6.5 26.8 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Med15 PF09606.10 CDI81392.1 - 4.1 6.0 49.6 6.2 5.4 49.6 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal NEMP PF10225.9 CDI81392.1 - 4.3 6.9 10.8 5.8 6.5 10.8 1.2 1 0 0 1 1 1 0 NEMP family CCSAP PF15748.5 CDI81392.1 - 4.3 7.4 33.3 5.1 7.2 33.3 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Hamartin PF04388.12 CDI81392.1 - 4.4 5.8 22.7 4.9 5.7 22.7 1.0 1 0 0 1 1 1 0 Hamartin protein Membralin PF09746.9 CDI81392.1 - 4.9 6.1 17.7 5.6 5.9 17.7 1.0 1 0 0 1 1 1 0 Tumour-associated protein AAA_11 PF13086.6 CDI81392.1 - 5 6.8 26.9 6.2 6.5 26.9 1.1 1 0 0 1 1 1 0 AAA domain Asp-B-Hydro_N PF05279.11 CDI81392.1 - 5.2 7.1 20.9 6 6.9 20.9 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Band_3_cyto PF07565.13 CDI81392.1 - 5.6 6.7 23.2 7.5 6.3 23.2 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PTPRCAP PF15713.5 CDI81392.1 - 5.8 7.2 26.1 7.4 6.8 26.1 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF2052 PF09747.9 CDI81392.1 - 6 7.0 30.9 7 6.7 30.9 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PA26 PF04636.13 CDI81392.1 - 6.4 5.6 20.4 7.3 5.4 20.4 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Afi1 PF07792.12 CDI81392.1 - 6.6 7.2 24.2 9.2 6.8 24.2 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DREPP PF05558.12 CDI81392.1 - 8.4 6.2 12.8 13 5.7 12.8 1.3 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Smg8_Smg9 PF10220.9 CDI81392.1 - 8.6 4.5 26.1 9.3 4.4 26.1 1.0 1 0 0 1 1 1 0 Smg8_Smg9 MAJIN PF15077.6 CDI81392.1 - 9.3 6.0 22.4 11 5.8 22.4 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF2040 PF09745.9 CDI81394.1 - 3.2e-06 27.2 33.4 0.0026 17.8 16.2 3.4 3 1 0 3 3 3 2 Coiled-coil domain-containing protein 55 (DUF2040) Sporozoite_P67 PF05642.11 CDI81394.1 - 0.17 9.9 23.6 2.8 5.9 23.7 2.2 1 1 0 1 1 1 0 Sporozoite P67 surface antigen Lin-8 PF03353.15 CDI81394.1 - 0.58 9.7 31.6 0.23 11.0 19.7 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist SPX PF03105.19 CDI81394.1 - 0.6 10.0 36.5 0.1 12.5 29.3 2.1 2 0 0 2 2 2 0 SPX domain RAP1 PF07218.11 CDI81394.1 - 9 4.4 32.5 2.3 6.4 21.7 2.1 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) EF-hand_7 PF13499.6 CDI81407.1 - 1.9e-07 31.4 0.0 5.7e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 CDI81407.1 - 2.7e-06 26.9 0.1 0.039 13.9 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 CDI81407.1 - 6.9e-05 22.1 0.0 0.0099 15.4 0.1 2.4 2 0 0 2 2 2 1 EF hand Spt20 PF12090.8 CDI81407.1 - 0.002 17.8 10.0 0.002 17.8 10.0 6.6 5 1 2 7 7 7 2 Spt20 family EF-hand_8 PF13833.6 CDI81407.1 - 0.013 15.3 0.0 0.29 11.0 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair ANAPC_CDC26 PF10471.9 CDI81407.1 - 0.029 15.2 9.7 0.029 15.2 9.7 8.7 5 2 2 7 7 7 0 Anaphase-promoting complex APC subunit CDC26 DUF4366 PF14283.6 CDI81407.1 - 0.1 12.6 0.2 0.1 12.6 0.2 4.5 3 2 0 4 4 4 0 Domain of unknown function (DUF4366) JmjC PF02373.22 CDI81407.1 - 0.28 11.6 0.1 0.28 11.6 0.1 4.1 2 1 2 4 4 4 0 JmjC domain, hydroxylase DUF4207 PF13904.6 CDI81408.1 - 0.0096 15.6 4.1 0.0096 15.6 4.1 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4207) Spt20 PF12090.8 CDI81408.1 - 0.018 14.7 50.6 0.047 13.3 17.1 3.3 3 0 0 3 3 3 0 Spt20 family SARAF PF06682.12 CDI81408.1 - 0.18 11.4 11.2 2.2 7.9 0.2 3.0 2 1 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis RskA PF10099.9 CDI81408.1 - 0.46 10.7 54.5 33 4.7 0.3 4.4 2 1 0 2 2 2 0 Anti-sigma-K factor rskA EPL1 PF10513.9 CDI81408.1 - 0.48 10.8 17.9 0.49 10.8 0.5 3.3 3 0 0 3 3 3 0 Enhancer of polycomb-like DUF2052 PF09747.9 CDI81408.1 - 0.78 9.8 21.8 0.033 14.3 7.5 2.9 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) AAA_23 PF13476.6 CDI81408.1 - 1.8 9.0 17.5 1.1 9.7 4.7 3.0 3 0 0 3 3 3 0 AAA domain PsbW PF07123.12 CDI81408.1 - 6.5 6.8 13.3 17 5.4 2.1 3.9 4 0 0 4 4 4 0 Photosystem II reaction centre W protein (PsbW) RPA43_OB PF17875.1 CDI81408.1 - 6.9 7.3 14.1 4.8 7.8 1.7 3.3 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I RIFIN PF02009.16 CDI81408.1 - 6.9 6.5 21.9 1.5 8.6 6.1 2.5 2 0 0 2 2 2 0 Rifin DUF3638 PF12340.8 CDI81411.1 - 2.1e-07 30.5 0.2 4.6e-07 29.4 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3638) Spt20 PF12090.8 CDI81411.1 - 0.0013 18.3 6.4 0.014 15.0 6.3 2.0 2 0 0 2 2 2 1 Spt20 family TFIIA PF03153.13 CDI81411.1 - 0.0036 17.3 11.0 0.0056 16.7 11.0 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SPX PF03105.19 CDI81411.1 - 0.027 14.4 6.4 0.037 14.0 6.4 1.1 1 0 0 1 1 1 0 SPX domain DDHD PF02862.17 CDI81411.1 - 0.031 14.4 3.7 1.5 8.9 0.2 2.1 2 0 0 2 2 2 0 DDHD domain DUF4834 PF16118.5 CDI81411.1 - 0.24 12.4 5.3 0.72 10.8 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF2722 PF10846.8 CDI81411.1 - 0.47 9.4 13.0 1.8 7.4 13.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2722) DUF1645 PF07816.11 CDI81411.1 - 1.4 9.5 13.9 2.8 8.5 7.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) DUF4834 PF16118.5 CDI81416.1 - 0.29 12.1 15.1 0.41 11.6 4.3 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) SEFIR PF08357.11 CDI81416.1 - 3.4 7.9 10.2 1.4 9.1 2.4 2.8 3 0 0 3 3 3 0 SEFIR domain NPR3 PF03666.13 CDI81433.1 - 7.9 5.1 45.5 9.5 4.9 45.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.12 CDI81433.1 - 9 6.0 50.8 11 5.8 50.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RskA PF10099.9 CDI81436.1 - 0.00018 21.8 29.2 0.006 16.9 20.8 2.2 2 0 0 2 2 2 2 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI81436.1 - 0.15 11.0 47.2 0.011 14.7 11.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) MecA PF05389.12 CDI81436.1 - 0.41 10.2 15.0 0.42 10.2 1.2 2.3 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) EOS1 PF12326.8 CDI81436.1 - 0.59 10.0 11.4 1.7 8.6 0.4 2.2 2 0 0 2 2 2 0 N-glycosylation protein FHIPEP PF00771.20 CDI81436.1 - 0.72 8.3 16.0 0.62 8.5 6.5 2.1 2 0 0 2 2 2 0 FHIPEP family ArsP_2 PF11449.8 CDI81436.1 - 0.89 8.7 7.7 1.1 8.4 2.6 2.1 2 0 0 2 2 2 0 Putative, 10TM heavy-metal exporter Connexin PF00029.19 CDI81436.1 - 1 9.0 15.8 2 8.1 1.5 2.2 2 0 0 2 2 2 0 Connexin Ndc1_Nup PF09531.10 CDI81436.1 - 1.1 7.9 19.0 1.4 7.6 19.0 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup UPF0560 PF10577.9 CDI81436.1 - 1.7 7.0 29.3 0.052 12.1 3.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 Med3 PF11593.8 CDI81436.1 - 4.9 6.3 59.9 0.39 9.9 34.1 2.2 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal DUF1980 PF09323.10 CDI81436.1 - 4.9 7.0 16.7 2.8 7.8 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF4207 PF13904.6 CDI81436.1 - 9.7 5.8 39.1 5.5 6.6 17.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) POPLD PF08170.12 CDI81443.1 - 1.5e-16 60.5 0.0 1.5e-16 60.5 0.0 5.0 4 2 1 5 5 5 1 POPLD (NUC188) domain DUF1635 PF07795.11 CDI81443.1 - 0.00071 19.5 5.2 0.00071 19.5 5.2 7.8 6 2 1 7 7 7 1 Protein of unknown function (DUF1635) Chorion_2 PF03964.15 CDI81450.1 - 0.0087 16.9 3.0 0.015 16.1 3.0 1.4 1 0 0 1 1 1 1 Chorion family 2 Spt20 PF12090.8 CDI81450.1 - 0.038 13.6 13.3 0.047 13.3 13.3 1.1 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI81450.1 - 0.074 13.0 13.7 0.074 13.0 13.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.19 CDI81450.1 - 0.09 13.4 6.7 0.15 12.7 6.7 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF2722 PF10846.8 CDI81450.1 - 0.14 11.0 8.6 0.18 10.8 8.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Macoilin PF09726.9 CDI81450.1 - 0.27 9.7 15.6 0.34 9.4 15.6 1.0 1 0 0 1 1 1 0 Macoilin family RCC1_2 PF13540.6 CDI81451.1 - 9.5e-08 31.7 4.9 0.00018 21.2 0.1 4.1 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 CDI81451.1 - 2.2e-07 31.4 5.7 0.00034 21.2 0.0 4.5 5 0 0 5 5 3 1 Regulator of chromosome condensation (RCC1) repeat ASC PF00858.24 CDI81451.1 - 8.8e-05 21.6 1.6 2.2 7.1 13.3 2.0 2 1 0 2 2 2 1 Amiloride-sensitive sodium channel DUF2722 PF10846.8 CDI81451.1 - 0.00095 18.2 0.3 0.00095 18.2 0.3 4.1 3 1 1 4 4 2 2 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI81451.1 - 0.0047 17.0 80.5 0.053 13.5 3.1 3.3 3 0 0 3 3 3 3 Transcription factor IIA, alpha/beta subunit SID-1_RNA_chan PF13965.6 CDI81451.1 - 0.007 14.8 0.2 0.012 14.0 0.0 1.5 2 0 0 2 2 2 1 dsRNA-gated channel SID-1 PA PF02225.22 CDI81451.1 - 0.032 14.3 1.1 11 6.2 0.4 3.0 2 0 0 2 2 2 0 PA domain Pex14_N PF04695.13 CDI81451.1 - 1.5 9.5 56.9 0.026 15.2 30.0 3.8 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Gti1_Pac2 PF09729.9 CDI81451.1 - 3 7.9 25.1 1.9e+02 2.0 0.0 2.9 3 0 0 3 3 3 0 Gti1/Pac2 family AUX_IAA PF02309.16 CDI81451.1 - 3.3 7.5 19.2 0.028 14.3 7.4 2.7 3 0 0 3 3 3 0 AUX/IAA family DUF913 PF06025.12 CDI81451.1 - 5.1 6.0 16.9 0.026 13.5 6.3 2.3 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) DUF4775 PF16001.5 CDI81451.1 - 5.5 6.3 19.8 14 5.0 19.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Peptidase_C2 PF00648.21 CDI81453.1 - 1.2e-07 31.0 0.0 3.8e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 Calpain family cysteine protease DUF2722 PF10846.8 CDI81453.1 - 0.011 14.7 0.2 0.011 14.7 0.2 5.4 5 0 0 5 5 5 0 Protein of unknown function (DUF2722) LRR_4 PF12799.7 CDI81454.1 - 0.00042 20.6 6.5 0.32 11.5 0.0 4.5 3 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDI81454.1 - 0.016 15.2 14.3 1 9.6 0.0 6.5 8 0 0 8 8 8 0 Leucine Rich repeat DUF2722 PF10846.8 CDI81457.1 - 0.00019 20.5 30.0 0.07 12.1 9.6 3.1 3 0 0 3 3 3 3 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI81457.1 - 0.00044 19.9 45.7 0.11 12.1 9.3 3.2 3 0 0 3 3 3 3 Spt20 family Eapp_C PF10238.9 CDI81457.1 - 0.019 15.1 8.2 1.5 8.9 0.7 3.3 3 0 0 3 3 3 0 E2F-associated phosphoprotein DUF4834 PF16118.5 CDI81457.1 - 0.031 15.2 19.0 0.18 12.8 2.6 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) SRP9-21 PF05486.12 CDI81457.1 - 0.29 11.6 8.8 8 6.9 0.1 3.9 4 0 0 4 4 4 0 Signal recognition particle 9 kDa protein (SRP9) FAM176 PF14851.6 CDI81457.1 - 0.45 10.2 7.5 5.1 6.7 0.1 3.0 3 0 0 3 3 3 0 FAM176 family DUF3464 PF11947.8 CDI81457.1 - 0.45 10.2 13.1 3.3 7.4 0.5 3.4 3 0 0 3 3 3 0 Photosynthesis affected mutant 68 MAS20 PF02064.15 CDI81457.1 - 0.77 9.9 17.0 1.7 8.7 1.8 3.4 3 0 0 3 3 3 0 MAS20 protein import receptor LIM_bind PF01803.16 CDI81457.1 - 0.96 8.9 15.8 3.1 7.3 2.1 3.1 3 0 0 3 3 3 0 LIM-domain binding protein FHIPEP PF00771.20 CDI81457.1 - 1.9 6.9 9.0 4.6 5.6 0.2 3.0 3 0 0 3 3 3 0 FHIPEP family Tic110 PF16940.5 CDI81457.1 - 2 6.8 12.2 2.8 6.3 12.2 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter EPL1 PF10513.9 CDI81457.1 - 2.5 8.5 16.3 3.5 8.0 1.8 3.2 3 0 0 3 3 3 0 Enhancer of polycomb-like ANAPC_CDC26 PF10471.9 CDI81457.1 - 3.9 8.4 47.3 0.68 10.8 7.2 3.8 4 0 0 4 4 3 0 Anaphase-promoting complex APC subunit CDC26 Activator_LAG-3 PF11498.8 CDI81457.1 - 3.9 6.3 57.7 0.13 11.3 6.2 3.1 3 0 0 3 3 3 0 Transcriptional activator LAG-3 SPG4 PF17325.2 CDI81457.1 - 4 8.6 11.2 2.9 9.0 0.1 3.4 3 0 0 3 3 3 0 Stationary phase protein 4 ORC_WH_C PF18137.1 CDI81457.1 - 4.1 7.5 16.5 13 5.9 0.2 2.7 2 1 0 2 2 2 0 Origin recognition complex winged helix C-terminal DUF775 PF05603.12 CDI81457.1 - 6.5 6.2 24.6 0.09 12.3 0.9 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF775) BRF1 PF07741.13 CDI81457.1 - 8.1 6.9 14.8 2.7 8.4 0.3 3.4 3 0 0 3 3 3 0 Brf1-like TBP-binding domain SR-25 PF10500.9 CDI81459.1 - 0.057 13.0 19.1 0.084 12.5 18.2 1.6 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein RAP1 PF07218.11 CDI81459.1 - 0.64 8.2 6.2 0.63 8.3 6.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RskA PF10099.9 CDI81459.1 - 1.4 9.1 36.9 0.65 10.3 8.5 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Peptidase_S64 PF08192.11 CDI81459.1 - 2.3 6.6 15.7 2.5 6.5 15.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF3043 PF11241.8 CDI81459.1 - 6.1 6.9 8.1 6.9 6.7 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) TFIIA PF03153.13 CDI81459.1 - 7.2 6.5 46.6 8.7 6.2 46.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TPR_14 PF13428.6 CDI81460.1 - 0.053 14.4 7.0 5.5 8.1 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Ribosomal_60s PF00428.19 CDI81460.1 - 0.35 11.5 6.2 0.6 10.7 6.2 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein ETRAMP PF09716.10 CDI81465.1 - 0.41 10.7 0.0 0.41 10.7 0.0 3.0 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) RskA PF10099.9 CDI81466.1 - 3.6e-05 24.1 6.3 3.6e-05 24.1 6.3 5.5 1 1 3 4 4 4 1 Anti-sigma-K factor rskA DUF3995 PF13160.6 CDI81466.1 - 0.65 10.4 7.9 0.6 10.5 2.6 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3995) GT87 PF09594.10 CDI81470.1 - 0.00025 20.9 0.3 0.029 14.1 0.1 2.4 2 0 0 2 2 2 2 Glycosyltransferase family 87 Ribosomal_60s PF00428.19 CDI81470.1 - 0.85 10.3 29.3 0.24 12.0 6.6 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein LRR19-TM PF15176.6 CDI81470.1 - 8.7 6.4 15.8 3.9 7.5 0.0 3.3 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain SR-25 PF10500.9 CDI81472.1 - 0.002 17.8 6.7 0.002 17.8 6.7 5.2 4 1 1 5 5 5 3 Nuclear RNA-splicing-associated protein DUF4834 PF16118.5 CDI81491.1 - 0.0055 17.6 1.5 0.0055 17.6 1.5 6.3 5 2 0 5 5 5 2 Domain of unknown function (DUF4834) SART-1 PF03343.13 CDI81491.1 - 2.1 6.8 55.4 0.0024 16.5 38.1 2.2 2 0 0 2 2 2 0 SART-1 family GPR15L PF15854.5 CDI81491.1 - 9.9 6.5 7.8 0.64 10.3 0.2 3.0 3 0 0 3 3 3 0 G-protein coupled receptor ligand 15 AP2 PF00847.20 CDI81493.1 - 0.00033 20.8 0.9 0.00033 20.8 0.9 5.9 6 0 0 6 6 6 1 AP2 domain SUIM_assoc PF16619.5 CDI81493.1 - 0.003 17.6 0.1 0.003 17.6 0.1 15.0 10 3 2 12 12 12 5 Unstructured region C-term to UIM in Ataxin3 Auxin_canalis PF05703.11 CDI81494.1 - 0.0013 18.8 34.7 0.0013 18.8 34.7 7.7 1 1 6 7 7 7 1 Auxin canalisation Trp_oprn_chp PF09534.10 CDI81494.1 - 0.0061 16.4 7.0 0.0061 16.4 7.0 7.7 7 2 1 8 8 8 2 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4342 PF14242.6 CDI81494.1 - 0.04 13.9 0.0 0.04 13.9 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4342) SPX PF03105.19 CDI81498.1 - 0.077 12.9 31.9 0.094 12.6 31.9 1.1 1 0 0 1 1 1 0 SPX domain Tic110 PF16940.5 CDI81498.1 - 0.12 10.9 10.9 0.14 10.6 10.9 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter TFIIA PF03153.13 CDI81498.1 - 0.31 11.0 40.8 0.45 10.4 40.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ERM PF00769.19 CDI81498.1 - 0.34 10.7 24.5 0.46 10.3 24.5 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family zf-C2H2_3rep PF18868.1 CDI81498.1 - 0.36 11.5 15.6 0.29 11.8 2.0 2.3 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats SID-1_RNA_chan PF13965.6 CDI81498.1 - 0.77 8.1 13.8 1 7.7 13.8 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 MAP65_ASE1 PF03999.12 CDI81498.1 - 0.86 8.2 33.9 1 8.0 33.9 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) BAF1_ABF1 PF04684.13 CDI81498.1 - 1.3 7.9 37.0 1.8 7.5 37.0 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SnAPC_2_like PF11035.8 CDI81498.1 - 1.6 8.8 24.9 1.8 8.6 24.9 1.0 1 0 0 1 1 1 0 Small nuclear RNA activating complex subunit 2, SNAP190 Myb LMF1 PF06762.14 CDI81498.1 - 1.8 7.6 8.0 2.1 7.4 8.0 1.0 1 0 0 1 1 1 0 Lipase maturation factor Tmemb_cc2 PF10267.9 CDI81498.1 - 3 6.9 29.9 4.4 6.3 29.9 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein WES_acyltransf PF03007.16 CDI81498.1 - 3.2 7.4 11.7 3.9 7.2 11.7 1.2 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF4637 PF15470.6 CDI81498.1 - 10 5.9 17.6 1.4 8.6 6.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) CRA PF06589.11 CDI81502.1 - 0.17 12.0 5.3 0.27 11.3 5.3 1.2 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) OATP PF03137.20 CDI81502.1 - 0.21 9.8 3.1 0.2 9.9 3.1 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family FAM76 PF16046.5 CDI81502.1 - 0.22 10.8 16.1 0.27 10.5 16.1 1.2 1 0 0 1 1 1 0 FAM76 protein Pap_E4 PF02711.14 CDI81502.1 - 0.24 12.4 10.8 0.45 11.5 10.8 1.5 1 0 0 1 1 1 0 E4 protein Bul1_N PF04425.12 CDI81502.1 - 0.35 9.6 10.7 0.38 9.5 10.7 1.2 1 0 0 1 1 1 0 Bul1 N terminus SLC12 PF03522.15 CDI81502.1 - 0.51 9.3 15.2 0.56 9.2 15.2 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Cellulose_synt PF03552.14 CDI81502.1 - 0.64 8.4 4.7 0.67 8.4 4.7 1.1 1 0 0 1 1 1 0 Cellulose synthase AF-4 PF05110.13 CDI81502.1 - 0.64 8.0 20.6 0.75 7.8 20.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PAT1 PF09770.9 CDI81502.1 - 0.64 8.2 29.8 0.83 7.9 29.8 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Dicty_REP PF05086.12 CDI81502.1 - 1.4 6.8 10.7 1.8 6.4 10.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein NPR3 PF03666.13 CDI81502.1 - 1.6 7.4 14.9 1.9 7.2 14.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PIG-S PF10510.9 CDI81502.1 - 3.4 6.4 15.5 4.4 6.0 15.5 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Peptidase_S64 PF08192.11 CDI81502.1 - 3.7 5.9 13.2 4.6 5.6 13.2 1.2 1 0 0 1 1 1 0 Peptidase family S64 MDM10 PF12519.8 CDI81502.1 - 4.5 6.0 12.7 5 5.9 12.7 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF4045 PF13254.6 CDI81502.1 - 4.5 6.8 17.6 5.9 6.4 17.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) BSP_II PF05432.11 CDI81502.1 - 4.6 6.9 17.8 5.8 6.5 17.8 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF4746 PF15928.5 CDI81502.1 - 5.9 6.2 24.3 14 5.0 24.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4746) Asp-B-Hydro_N PF05279.11 CDI81502.1 - 9.2 6.2 22.3 14 5.7 22.3 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region RskA PF10099.9 CDI81513.1 - 0.004 17.5 16.9 0.004 17.5 16.9 2.6 1 1 1 2 2 1 1 Anti-sigma-K factor rskA CNDH2_N PF06278.11 CDI81513.1 - 0.012 15.8 0.1 0.012 15.8 0.1 2.5 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Presenilin PF01080.17 CDI81513.1 - 0.023 13.5 16.7 0.028 13.2 16.7 1.1 1 0 0 1 1 1 0 Presenilin DUF1180 PF06679.12 CDI81513.1 - 0.19 12.1 19.5 0.054 13.9 7.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1180) SID-1_RNA_chan PF13965.6 CDI81513.1 - 0.29 9.5 1.8 0.4 9.0 1.8 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 UPF0239 PF06783.11 CDI81513.1 - 0.37 11.0 15.4 1.5 9.0 0.7 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) DUF3807 PF12720.7 CDI81513.1 - 0.51 10.6 22.3 1.7 8.9 2.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Thg1C PF14413.6 CDI81513.1 - 0.95 9.6 12.5 5.6 7.1 0.3 2.3 2 0 0 2 2 2 0 Thg1 C terminal domain EIIBC-GUT_N PF03612.14 CDI81513.1 - 3.8 7.2 13.9 3.4 7.4 0.5 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus U3_snoRNA_assoc PF08297.11 CDI81513.1 - 3.8 8.3 15.7 18 6.2 0.3 2.3 2 0 0 2 2 2 0 U3 snoRNA associated Peroxin-13_N PF04088.13 CDI81513.1 - 5.8 7.2 10.0 3.9 7.7 0.3 2.2 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Bac_luciferase PF00296.20 CDI81513.1 - 7.3 5.9 12.7 0.044 13.2 1.4 2.0 1 1 1 2 2 2 0 Luciferase-like monooxygenase V_ATPase_I PF01496.19 CDI81521.1 - 1.5e-06 26.4 19.1 1.7e-06 26.3 19.1 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI81521.1 - 0.00011 21.4 13.3 0.00011 21.4 13.3 1.0 1 0 0 1 1 1 1 CLN3 protein SID-1_RNA_chan PF13965.6 CDI81521.1 - 0.00043 18.8 4.7 0.00044 18.8 4.7 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 PIP5K PF01504.18 CDI81521.1 - 0.0005 19.4 11.5 0.0005 19.4 11.5 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Connexin PF00029.19 CDI81521.1 - 0.00057 19.7 12.8 0.00064 19.6 12.8 1.1 1 0 0 1 1 1 1 Connexin CBP_BcsG PF11658.8 CDI81521.1 - 0.00058 18.4 13.2 0.00061 18.3 13.2 1.0 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG CSG2 PF16965.5 CDI81521.1 - 0.0012 17.8 10.5 0.0014 17.7 10.5 1.0 1 0 0 1 1 1 1 Ceramide synthase regulator SpoIIP PF07454.11 CDI81521.1 - 0.0048 16.4 19.6 0.0051 16.3 19.6 1.0 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Serinc PF03348.15 CDI81521.1 - 0.0048 15.9 7.3 0.0048 15.9 7.3 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) O-antigen_lig PF13425.6 CDI81521.1 - 0.0049 15.7 4.8 0.0052 15.6 4.8 1.1 1 0 0 1 1 1 1 O-antigen ligase like membrane protein SARAF PF06682.12 CDI81521.1 - 0.011 15.4 14.1 0.012 15.3 14.1 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF913 PF06025.12 CDI81521.1 - 0.012 14.6 8.8 0.012 14.7 8.8 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TRAP_alpha PF03896.16 CDI81521.1 - 0.014 14.6 12.8 0.016 14.4 12.8 1.2 1 1 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Folate_carrier PF01770.18 CDI81521.1 - 0.016 13.9 9.7 0.017 13.8 9.7 1.1 1 0 0 1 1 1 0 Reduced folate carrier Pex24p PF06398.11 CDI81521.1 - 0.017 14.1 1.9 0.026 13.5 1.9 1.4 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin CobT PF06213.12 CDI81521.1 - 0.018 14.5 30.4 0.02 14.3 30.4 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SLC12 PF03522.15 CDI81521.1 - 0.022 13.8 18.4 0.022 13.8 18.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Pannexin_like PF12534.8 CDI81521.1 - 0.027 13.6 10.5 0.031 13.4 10.5 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 MMM1 PF10296.9 CDI81521.1 - 0.03 13.4 12.2 0.033 13.2 12.2 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Peptidase_S49_N PF08496.10 CDI81521.1 - 0.036 14.1 17.1 0.046 13.8 17.1 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CCDC53 PF10152.9 CDI81521.1 - 0.037 14.5 20.5 0.039 14.4 20.5 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Velvet PF11754.8 CDI81521.1 - 0.051 13.5 16.9 0.051 13.5 16.9 1.0 1 0 0 1 1 1 0 Velvet factor DDHD PF02862.17 CDI81521.1 - 0.055 13.6 16.1 0.065 13.4 16.1 1.2 1 0 0 1 1 1 0 DDHD domain UbiA PF01040.18 CDI81521.1 - 0.063 12.6 0.1 0.071 12.4 0.1 1.0 1 0 0 1 1 1 0 UbiA prenyltransferase family CPSF100_C PF13299.6 CDI81521.1 - 0.073 13.2 14.8 0.087 13.0 14.8 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4131 PF13567.6 CDI81521.1 - 0.081 12.6 15.3 0.13 11.9 15.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) Tmp39 PF10271.9 CDI81521.1 - 0.11 11.5 8.9 0.12 11.3 8.9 1.0 1 0 0 1 1 1 0 Putative transmembrane protein RNA_pol_Rpc4 PF05132.14 CDI81521.1 - 0.15 12.5 19.5 0.17 12.3 19.5 1.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF4746 PF15928.5 CDI81521.1 - 0.16 11.4 15.0 0.17 11.3 15.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4010 PF13194.6 CDI81521.1 - 0.18 11.5 4.8 0.21 11.2 4.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4010) Nucleoside_tran PF01733.18 CDI81521.1 - 0.22 10.9 6.0 0.24 10.8 6.0 1.1 1 0 0 1 1 1 0 Nucleoside transporter CRA PF06589.11 CDI81521.1 - 0.33 11.1 2.8 0.16 12.1 1.0 1.4 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) DUF2828 PF11443.8 CDI81521.1 - 0.45 8.5 24.1 0.51 8.4 24.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Baculo_PP31 PF05311.11 CDI81521.1 - 0.45 9.9 18.1 0.54 9.7 18.1 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF2561 PF10812.8 CDI81521.1 - 0.49 10.4 1.4 0.5 10.4 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) Scs3p PF10261.9 CDI81521.1 - 0.57 9.7 9.8 0.75 9.3 9.8 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Sre PF03125.18 CDI81521.1 - 0.78 8.8 3.3 0.84 8.7 3.3 1.0 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor BORG_CEP PF14957.6 CDI81521.1 - 0.9 10.7 14.6 1 10.5 14.6 1.1 1 0 0 1 1 1 0 Cdc42 effector AUX_IAA PF02309.16 CDI81521.1 - 1.1 9.1 12.9 1.1 9.0 12.9 1.1 1 0 0 1 1 1 0 AUX/IAA family NEMP PF10225.9 CDI81521.1 - 1.1 8.8 11.3 1.2 8.7 11.3 1.1 1 0 0 1 1 1 0 NEMP family FAM176 PF14851.6 CDI81521.1 - 1.1 8.9 19.3 0.89 9.2 18.3 1.5 1 1 1 2 2 1 0 FAM176 family Mem_trans PF03547.18 CDI81521.1 - 1.2 7.5 7.7 1.2 7.4 7.7 1.1 1 0 0 1 1 1 0 Membrane transport protein Tmemb_9 PF05434.11 CDI81521.1 - 1.3 8.9 22.7 1.6 8.6 22.7 1.1 1 0 0 1 1 1 0 TMEM9 DUF5313 PF17240.2 CDI81521.1 - 1.6 9.2 9.1 2.7 8.4 9.1 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5313) Bac_export_2 PF01312.19 CDI81521.1 - 1.7 7.8 11.9 1.9 7.7 11.9 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family HemX PF04375.14 CDI81521.1 - 1.9 7.7 47.3 2 7.6 47.3 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase NicO PF03824.16 CDI81521.1 - 1.9 7.8 6.0 2.6 7.3 5.9 1.4 1 1 0 1 1 1 0 High-affinity nickel-transport protein DUF4228 PF14009.6 CDI81521.1 - 2.1 8.7 11.8 2.4 8.5 11.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) YfhO PF09586.10 CDI81521.1 - 2.4 6.3 19.9 4.4 5.4 19.9 1.5 1 1 0 1 1 1 0 Bacterial membrane protein YfhO G6B PF15096.6 CDI81521.1 - 4.1 7.1 5.4 4.8 6.9 5.4 1.2 1 0 0 1 1 1 0 G6B family DUF4446 PF14584.6 CDI81521.1 - 4.4 7.3 16.7 6 6.8 16.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) DUF2126 PF09899.9 CDI81521.1 - 4.5 5.2 20.0 5 5.1 20.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF4834 PF16118.5 CDI81521.1 - 4.9 8.2 36.9 3e+02 2.4 36.9 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Tim54 PF11711.8 CDI81521.1 - 5.8 5.6 23.3 6.5 5.4 23.3 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ureide_permease PF07168.11 CDI81521.1 - 5.9 5.5 11.6 7.1 5.3 11.6 1.2 1 0 0 1 1 1 0 Ureide permease TerC PF03741.16 CDI81521.1 - 6.7 6.4 8.3 20 4.8 8.3 1.8 1 1 0 1 1 1 0 Integral membrane protein TerC family DUF1980 PF09323.10 CDI81521.1 - 9.4 6.1 24.7 5.3 6.9 22.7 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) DUF572 PF04502.13 CDI81525.1 - 0.00055 19.7 52.2 0.032 13.8 1.5 2.2 2 0 0 2 2 2 2 Family of unknown function (DUF572) SpoIIIAH PF12685.7 CDI81525.1 - 0.0024 17.8 21.6 0.0024 17.8 21.6 3.3 3 0 0 3 3 3 2 SpoIIIAH-like protein Oxidored_q3 PF00499.20 CDI81525.1 - 0.0025 17.5 0.2 1.6 8.5 0.0 2.9 2 1 0 2 2 2 2 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF4199 PF13858.6 CDI81525.1 - 0.0051 17.2 4.7 0.0051 17.2 4.7 4.9 3 1 1 5 5 5 1 Protein of unknown function (DUF4199) TFIIA PF03153.13 CDI81525.1 - 0.0062 16.6 27.8 0.0062 16.6 27.8 4.0 3 1 0 3 3 3 2 Transcription factor IIA, alpha/beta subunit Orf78 PF06024.12 CDI81525.1 - 0.083 13.2 0.4 0.083 13.2 0.4 6.2 2 2 3 5 5 5 0 Orf78 (ac78) DUF2052 PF09747.9 CDI81525.1 - 2.2 8.4 71.6 0.029 14.5 3.4 3.4 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Endostatin PF06482.11 CDI81525.1 - 8.5 5.7 62.3 0.56 9.6 2.3 3.4 3 0 0 3 3 3 0 Collagenase NC10 and Endostatin PIH1 PF08190.12 CDI81527.1 - 2.7e-06 27.0 0.1 0.00014 21.4 0.0 4.9 5 0 0 5 5 5 2 PIH1 N-terminal domain SR-25 PF10500.9 CDI81527.1 - 0.0019 17.9 29.2 0.0019 17.9 29.2 9.1 8 3 1 9 9 9 2 Nuclear RNA-splicing-associated protein OmpH PF03938.14 CDI81528.1 - 0.029 14.7 17.5 0.7 10.2 9.3 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Cellulose_synt PF03552.14 CDI81528.1 - 0.83 8.1 12.4 0.48 8.9 3.0 2.3 2 0 0 2 2 2 0 Cellulose synthase Mucin PF01456.17 CDI81530.1 - 1.6e-05 24.9 1.9 1.9e-05 24.7 1.9 1.1 1 0 0 1 1 1 1 Mucin-like glycoprotein FAM176 PF14851.6 CDI81530.1 - 8.7e-05 22.2 2.6 9.8e-05 22.0 2.6 1.1 1 0 0 1 1 1 1 FAM176 family DUF4834 PF16118.5 CDI81530.1 - 0.00013 22.9 11.9 0.00027 21.8 11.9 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4834) TssO PF17561.2 CDI81530.1 - 0.00046 20.3 4.6 0.00058 20.0 4.6 1.1 1 0 0 1 1 1 1 Type VI secretion system, TssO V_ATPase_I PF01496.19 CDI81530.1 - 0.00075 17.6 6.8 0.00079 17.5 6.8 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family TMEM51 PF15345.6 CDI81530.1 - 0.0032 17.3 13.8 0.0032 17.3 13.8 1.7 1 1 1 2 2 2 1 Transmembrane protein 51 Ctr PF04145.15 CDI81530.1 - 0.0046 17.6 4.9 0.0057 17.3 4.9 1.2 1 0 0 1 1 1 1 Ctr copper transporter family Presenilin PF01080.17 CDI81530.1 - 0.0049 15.7 7.6 0.0058 15.4 7.6 1.2 1 0 0 1 1 1 1 Presenilin TRAP_alpha PF03896.16 CDI81530.1 - 0.0067 15.7 3.1 0.0068 15.7 3.1 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit SID-1_RNA_chan PF13965.6 CDI81530.1 - 0.0096 14.4 3.7 0.0099 14.3 3.7 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 OATP PF03137.20 CDI81530.1 - 0.01 14.2 1.4 0.011 14.0 1.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family ABC2_membrane_2 PF12679.7 CDI81530.1 - 0.013 14.8 5.5 0.016 14.5 5.5 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Ndc1_Nup PF09531.10 CDI81530.1 - 0.013 14.2 9.2 0.016 14.0 9.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NicO PF03824.16 CDI81530.1 - 0.013 14.8 4.7 0.014 14.7 4.7 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein MTABC_N PF16185.5 CDI81530.1 - 0.014 14.9 2.0 0.018 14.5 2.0 1.2 1 0 0 1 1 1 0 Mitochondrial ABC-transporter N-terminal five TM region Connexin PF00029.19 CDI81530.1 - 0.019 14.7 2.8 0.019 14.7 2.8 1.1 1 0 0 1 1 1 0 Connexin FAM209 PF15206.6 CDI81530.1 - 0.024 14.4 0.8 0.028 14.2 0.8 1.2 1 0 0 1 1 1 0 FAM209 family DUF2514 PF10721.9 CDI81530.1 - 0.026 14.6 17.5 0.038 14.0 17.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) CLN3 PF02487.17 CDI81530.1 - 0.028 13.5 6.8 0.029 13.4 6.8 1.0 1 0 0 1 1 1 0 CLN3 protein FPN1 PF06963.12 CDI81530.1 - 0.032 12.8 3.1 0.034 12.7 3.1 1.2 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Spt20 PF12090.8 CDI81530.1 - 0.036 13.7 34.7 0.052 13.2 34.7 1.2 1 0 0 1 1 1 0 Spt20 family DUF4446 PF14584.6 CDI81530.1 - 0.037 14.0 4.0 0.041 13.9 4.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) O-antigen_lig PF13425.6 CDI81530.1 - 0.042 12.6 0.6 0.041 12.7 0.6 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF3357 PF11837.8 CDI81530.1 - 0.053 14.0 1.1 0.053 14.0 1.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) PIP5K PF01504.18 CDI81530.1 - 0.056 12.7 3.8 0.058 12.6 3.8 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Spore_III_AF PF09581.10 CDI81530.1 - 0.059 13.4 6.9 0.075 13.1 6.9 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) Tmp39 PF10271.9 CDI81530.1 - 0.081 11.9 3.1 0.088 11.8 3.1 1.0 1 0 0 1 1 1 0 Putative transmembrane protein OAD_gamma PF04277.13 CDI81530.1 - 0.087 13.4 7.7 5.2 7.7 7.7 2.2 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Tmemb_9 PF05434.11 CDI81530.1 - 0.088 12.7 10.5 0.058 13.3 9.0 1.4 1 1 1 2 2 2 0 TMEM9 XRN_M PF17846.1 CDI81530.1 - 0.089 11.7 9.7 0.1 11.5 9.7 1.0 1 0 0 1 1 1 0 Xrn1 helical domain MLANA PF14991.6 CDI81530.1 - 0.093 13.0 3.6 0.11 12.7 3.6 1.3 1 1 0 1 1 1 0 Protein melan-A RIFIN PF02009.16 CDI81530.1 - 0.11 12.4 9.0 0.12 12.2 9.0 1.1 1 0 0 1 1 1 0 Rifin DUF3292 PF11696.8 CDI81530.1 - 0.12 10.8 11.1 0.14 10.5 11.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF2368 PF10166.9 CDI81530.1 - 0.12 12.0 16.7 0.14 11.7 16.7 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) CSG2 PF16965.5 CDI81530.1 - 0.12 11.2 3.8 0.13 11.2 3.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF599 PF04654.12 CDI81530.1 - 0.15 11.4 3.2 0.18 11.2 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF599 Dpy19 PF10034.9 CDI81530.1 - 0.15 10.2 5.0 0.16 10.1 5.0 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation DUF1180 PF06679.12 CDI81530.1 - 0.16 12.4 7.9 0.19 12.1 7.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF2722 PF10846.8 CDI81530.1 - 0.16 10.9 26.3 0.17 10.8 26.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Scs3p PF10261.9 CDI81530.1 - 0.16 11.4 4.4 0.19 11.2 4.4 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM EphA2_TM PF14575.6 CDI81530.1 - 0.18 12.7 10.2 0.51 11.2 10.2 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain 7tm_1 PF00001.21 CDI81530.1 - 0.19 11.0 0.5 0.22 10.8 0.5 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) HRXXH PF13933.6 CDI81530.1 - 0.25 10.9 7.3 0.29 10.6 7.3 1.1 1 0 0 1 1 1 0 Putative peptidase family Comm PF15957.5 CDI81530.1 - 0.31 11.4 4.2 0.62 10.4 4.2 1.7 1 1 0 1 1 1 0 Commissureless SLC12 PF03522.15 CDI81530.1 - 0.33 9.9 11.4 0.37 9.8 11.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4492 PF14899.6 CDI81530.1 - 0.4 10.6 3.1 1.3 9.0 3.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4492) DUF2828 PF11443.8 CDI81530.1 - 0.42 8.7 11.4 0.46 8.5 11.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Pex14_N PF04695.13 CDI81530.1 - 0.44 11.2 20.6 0.63 10.7 20.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Arv1 PF04161.13 CDI81530.1 - 0.44 10.7 4.7 0.53 10.4 4.7 1.1 1 0 0 1 1 1 0 Arv1-like family ALG3 PF05208.13 CDI81530.1 - 0.48 9.8 3.9 0.5 9.7 3.9 1.2 1 0 0 1 1 1 0 ALG3 protein DUF2572 PF10833.8 CDI81530.1 - 0.56 9.9 14.2 0.61 9.8 14.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) OSTbeta PF15048.6 CDI81530.1 - 0.59 10.3 8.6 0.93 9.6 8.6 1.5 1 1 0 1 1 1 0 Organic solute transporter subunit beta protein FliP PF00813.20 CDI81530.1 - 0.59 10.0 6.4 0.67 9.8 6.4 1.1 1 0 0 1 1 1 0 FliP family DUF4330 PF14221.6 CDI81530.1 - 0.7 10.1 4.6 1.4 9.1 4.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4330) PigN PF04987.14 CDI81530.1 - 0.75 8.6 7.6 0.79 8.5 7.1 1.3 1 1 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) DUF2232 PF09991.9 CDI81530.1 - 0.77 8.9 8.1 0.91 8.6 8.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) PH_4 PF15404.6 CDI81530.1 - 1 9.2 9.0 0.92 9.3 8.2 1.3 1 1 0 1 1 1 0 Pleckstrin homology domain Tau95_N PF17682.1 CDI81530.1 - 1 9.6 8.3 0.97 9.6 7.5 1.3 1 1 0 1 1 1 0 Tau95 Triple barrel domain GRP PF07172.11 CDI81530.1 - 1.1 10.0 7.2 1.7 9.4 7.2 1.7 1 1 0 1 1 1 0 Glycine rich protein family TFIIA PF03153.13 CDI81530.1 - 1.1 9.2 35.9 1.3 9.0 35.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4638 PF15472.6 CDI81530.1 - 1.1 8.9 8.5 1.2 8.8 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) EPL1 PF10513.9 CDI81530.1 - 1.2 9.5 14.3 1.4 9.3 14.3 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like YABBY PF04690.13 CDI81530.1 - 1.3 9.6 9.0 1.8 9.1 9.0 1.3 1 0 0 1 1 1 0 YABBY protein TERB2 PF15101.6 CDI81530.1 - 1.5 8.8 18.9 1.8 8.6 18.9 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 WBP-1 PF11669.8 CDI81530.1 - 1.5 9.5 10.6 4.1 8.1 10.6 1.8 1 1 0 1 1 1 0 WW domain-binding protein 1 Membralin PF09746.9 CDI81530.1 - 1.5 7.8 7.2 1.7 7.6 7.2 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF4199 PF13858.6 CDI81530.1 - 1.5 9.2 8.0 1.8 8.9 7.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) CPSF100_C PF13299.6 CDI81530.1 - 1.7 8.8 13.1 2.1 8.5 13.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF3371 PF11851.8 CDI81530.1 - 1.7 9.7 16.0 2.5 9.2 16.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) UPF0542 PF15086.6 CDI81530.1 - 1.8 8.6 9.2 8.2 6.4 9.2 2.0 1 1 0 1 1 1 0 Uncharacterised protein family UPF0542 UPF0565 PF10561.9 CDI81530.1 - 1.9 7.6 8.4 2.3 7.3 8.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 MFAP1 PF06991.11 CDI81530.1 - 2 8.2 16.9 2.4 8.0 16.9 1.1 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing ALMT PF11744.8 CDI81530.1 - 2 7.1 10.6 2.2 7.0 10.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2227 PF09988.9 CDI81530.1 - 2.1 8.2 9.2 4.2 7.2 9.2 1.7 1 1 0 1 1 1 0 Uncharacterized metal-binding protein (DUF2227) eIF-3_zeta PF05091.12 CDI81530.1 - 2.2 7.2 16.2 2.4 7.0 16.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MPM1 PF17234.2 CDI81530.1 - 2.5 8.3 12.6 3 8.1 12.6 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 BAT2_N PF07001.11 CDI81530.1 - 2.7 8.4 21.0 3.3 8.1 21.0 1.1 1 0 0 1 1 1 0 BAT2 N-terminus DUF2140 PF09911.9 CDI81530.1 - 2.9 7.4 11.1 6.3 6.3 11.1 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) MCU PF04678.13 CDI81530.1 - 3.3 7.8 11.3 3.9 7.5 11.3 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Tetraspanin PF00335.20 CDI81530.1 - 3.3 7.4 8.7 3 7.5 8.1 1.3 1 1 0 1 1 1 0 Tetraspanin family DUF3112 PF11309.8 CDI81530.1 - 3.7 6.9 5.6 5.2 6.4 5.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3112) Conotoxin PF02950.17 CDI81530.1 - 3.9 8.6 15.0 31 5.7 15.0 2.4 1 1 0 1 1 1 0 Conotoxin AUX_IAA PF02309.16 CDI81530.1 - 4 7.2 12.0 4.7 7.0 12.0 1.0 1 0 0 1 1 1 0 AUX/IAA family DUF702 PF05142.12 CDI81530.1 - 4.2 7.8 15.4 5.7 7.4 15.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) USP8_interact PF08941.10 CDI81530.1 - 5.1 6.9 14.8 5.9 6.7 14.8 1.2 1 0 0 1 1 1 0 USP8 interacting Endonuc_Holl PF10107.9 CDI81530.1 - 5.2 6.9 11.7 4.3 7.2 10.8 1.3 1 1 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase PAT1 PF09770.9 CDI81530.1 - 5.4 5.2 27.8 6.5 4.9 27.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Gti1_Pac2 PF09729.9 CDI81530.1 - 6.1 6.9 11.0 7 6.7 11.0 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family BRF1 PF07741.13 CDI81530.1 - 6.5 7.2 12.4 9.6 6.6 12.4 1.3 1 0 0 1 1 1 0 Brf1-like TBP-binding domain 7tm_7 PF08395.12 CDI81530.1 - 7.3 5.7 14.0 8.3 5.5 14.0 1.1 1 0 0 1 1 1 0 7tm Chemosensory receptor NST1 PF13945.6 CDI81530.1 - 9.4 6.3 20.1 12 5.9 20.1 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator MAT1 PF06391.13 CDI81530.1 - 9.4 6.0 20.0 11 5.7 20.0 1.0 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 HemX PF04375.14 CDI81530.1 - 9.8 5.4 35.7 12 5.1 35.7 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase CemA PF03040.14 CDI81530.1 - 9.9 6.0 9.7 11 5.8 9.7 1.1 1 0 0 1 1 1 0 CemA family DEAD PF00270.29 CDI81532.1 - 3.3e-15 56.3 0.0 3.3e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDI81532.1 - 0.11 12.4 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Secretin_N_2 PF07655.13 CDI81532.1 - 0.65 10.6 14.5 2.6 8.7 2.6 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Tic110 PF16940.5 CDI81532.1 - 2 6.8 5.0 2.7 6.4 5.0 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter Shadoo PF14999.6 CDI81532.1 - 2.7 8.1 12.6 0.36 10.9 8.3 1.7 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective DUF4667 PF15700.5 CDI81532.1 - 5.8 6.9 15.6 0.23 11.5 1.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) MOZART1 PF12554.8 CDI81538.1 - 1.1e-20 73.1 0.7 1.7e-20 72.5 0.7 1.2 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated PCM1_C PF15717.5 CDI81538.1 - 0.1 11.3 0.9 1.4 7.6 0.1 2.0 1 1 1 2 2 2 0 Pericentriolar material 1 C terminus PAP2 PF01569.21 CDI81543.1 - 0.011 15.5 0.4 0.7 9.7 1.0 2.6 1 1 1 2 2 2 0 PAP2 superfamily SR-25 PF10500.9 CDI81543.1 - 1.3 8.6 26.7 0.21 11.2 14.4 2.4 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein PVL_ORF50 PF07768.11 CDI81543.1 - 2.9 8.2 14.6 1.6 9.1 7.3 2.5 2 0 0 2 2 2 0 PVL ORF-50-like family Med15 PF09606.10 CDI81546.1 - 0.2 10.3 10.7 0.24 10.0 10.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal FA_desaturase PF00487.24 CDI81546.1 - 0.67 9.7 2.5 0.76 9.6 2.5 1.1 1 0 0 1 1 1 0 Fatty acid desaturase TFIIA PF03153.13 CDI81546.1 - 1.6 8.6 9.5 2.3 8.1 9.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1115 PF06544.12 CDI81550.1 - 0.0024 18.0 6.7 0.0028 17.7 6.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) Afi1 PF07792.12 CDI81550.1 - 0.03 14.8 10.4 0.031 14.8 10.4 1.0 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4834 PF16118.5 CDI81550.1 - 0.099 13.6 12.9 0.12 13.4 12.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Baculo_PP31 PF05311.11 CDI81550.1 - 0.1 12.1 7.7 0.1 12.1 7.7 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) CCDC53 PF10152.9 CDI81550.1 - 0.12 12.8 10.0 0.13 12.7 10.0 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex ATP11 PF06644.11 CDI81550.1 - 0.2 11.4 13.5 0.22 11.3 13.5 1.0 1 0 0 1 1 1 0 ATP11 protein Pex14_N PF04695.13 CDI81550.1 - 0.23 12.1 15.5 0.24 12.0 15.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Tim54 PF11711.8 CDI81550.1 - 0.25 10.1 10.2 0.25 10.1 10.2 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CPSF100_C PF13299.6 CDI81550.1 - 0.28 11.4 9.6 0.28 11.4 9.6 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF1764 PF08576.10 CDI81550.1 - 0.44 11.5 12.0 0.49 11.3 12.0 1.0 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Spt20 PF12090.8 CDI81550.1 - 0.45 10.1 36.9 0.51 9.9 36.9 1.1 1 0 0 1 1 1 0 Spt20 family DUF3464 PF11947.8 CDI81550.1 - 0.5 10.1 12.6 0.55 10.0 12.6 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 NARP1 PF12569.8 CDI81550.1 - 0.53 9.1 12.0 0.51 9.2 12.0 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF5327 PF17261.2 CDI81550.1 - 0.54 11.0 20.6 0.67 10.7 20.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5327) DUF4820 PF16091.5 CDI81550.1 - 0.55 9.6 10.7 0.59 9.5 10.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) CobT PF06213.12 CDI81550.1 - 0.56 9.5 20.2 0.56 9.6 20.2 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Peptidase_S49_N PF08496.10 CDI81550.1 - 0.62 10.1 12.6 0.64 10.1 12.6 1.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Rxt3 PF08642.10 CDI81550.1 - 0.72 10.6 6.5 0.85 10.4 6.5 1.1 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 GNAT_acetyltr_2 PF13718.6 CDI81550.1 - 0.74 9.2 8.8 0.75 9.1 8.8 1.0 1 0 0 1 1 1 0 GNAT acetyltransferase 2 RR_TM4-6 PF06459.12 CDI81550.1 - 0.8 9.5 13.0 0.84 9.4 13.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 CDI81550.1 - 0.81 9.8 11.1 0.87 9.7 11.1 1.0 1 0 0 1 1 1 0 DDHD domain AAA_28 PF13521.6 CDI81550.1 - 0.9 9.8 5.5 1 9.6 5.5 1.1 1 0 0 1 1 1 0 AAA domain TFIIA PF03153.13 CDI81550.1 - 0.96 9.4 31.0 0.96 9.4 31.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BRF1 PF07741.13 CDI81550.1 - 1 9.8 12.0 1.2 9.5 12.0 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain F-protein PF00469.20 CDI81550.1 - 1 8.9 10.4 1.1 8.8 10.4 1.0 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef DUF2828 PF11443.8 CDI81550.1 - 1.1 7.3 11.5 1.1 7.3 11.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) AIF_C PF14721.6 CDI81550.1 - 1.1 9.6 11.3 1.2 9.4 11.3 1.0 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term MecA PF05389.12 CDI81550.1 - 1.1 8.8 12.4 1.2 8.7 12.4 1.0 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF2235 PF09994.9 CDI81550.1 - 1.1 8.5 8.9 1.2 8.4 8.9 1.0 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) SpoIIP PF07454.11 CDI81550.1 - 1.2 8.6 15.0 1.2 8.5 15.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Suf PF05843.14 CDI81550.1 - 1.2 9.1 16.6 1.2 9.1 16.6 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RAB3GAP2_C PF14656.6 CDI81550.1 - 1.2 7.2 12.5 1.3 7.1 12.5 1.0 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus PPL5 PF18168.1 CDI81550.1 - 1.2 8.3 8.8 1.2 8.4 8.8 1.0 1 0 0 1 1 1 0 Prim-pol family 5 HA2 PF04408.23 CDI81550.1 - 1.3 9.4 7.4 1.5 9.2 7.4 1.1 1 0 0 1 1 1 0 Helicase associated domain (HA2) Band_3_cyto PF07565.13 CDI81550.1 - 1.3 8.8 11.4 1.3 8.7 11.4 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Presenilin PF01080.17 CDI81550.1 - 1.3 7.7 14.4 1.4 7.6 14.4 1.0 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI81550.1 - 1.3 8.9 8.0 1.5 8.8 8.0 1.0 1 0 0 1 1 1 0 Protein Family FAM60A EIIBC-GUT_N PF03612.14 CDI81550.1 - 1.4 8.6 13.7 1.6 8.5 13.7 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CRF1 PF10380.9 CDI81550.1 - 1.4 9.3 6.4 1.5 9.2 6.4 1.1 1 0 0 1 1 1 0 Transcription factor CRF1 G0-G1_switch_2 PF15103.6 CDI81550.1 - 1.4 9.3 9.1 1.7 9.1 9.1 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 DUF3381 PF11861.8 CDI81550.1 - 1.5 8.6 17.9 1.8 8.4 17.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) CLN3 PF02487.17 CDI81550.1 - 1.6 7.7 8.6 1.5 7.8 8.6 1.0 1 0 0 1 1 1 0 CLN3 protein TERB2 PF15101.6 CDI81550.1 - 1.7 8.6 19.7 1.9 8.5 19.7 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Peroxin-13_N PF04088.13 CDI81550.1 - 1.7 8.9 7.8 1.9 8.7 7.8 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region eIF-3_zeta PF05091.12 CDI81550.1 - 1.7 7.5 16.6 1.8 7.4 16.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Folliculin PF11704.8 CDI81550.1 - 1.8 8.4 10.2 1.8 8.4 10.2 1.0 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Connexin PF00029.19 CDI81550.1 - 1.9 8.2 9.8 1.9 8.2 9.8 1.0 1 0 0 1 1 1 0 Connexin Conotoxin PF02950.17 CDI81550.1 - 2 9.5 8.1 2.6 9.1 8.1 1.2 1 0 0 1 1 1 0 Conotoxin ALMT PF11744.8 CDI81550.1 - 2 7.1 10.1 2.2 7.0 10.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter YABBY PF04690.13 CDI81550.1 - 2.2 8.8 8.4 2.2 8.8 8.4 1.1 1 0 0 1 1 1 0 YABBY protein MDM31_MDM32 PF08118.11 CDI81550.1 - 2.3 6.8 10.2 2.4 6.7 10.2 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF4746 PF15928.5 CDI81550.1 - 2.4 7.5 12.0 2.6 7.4 12.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MMR1 PF08505.10 CDI81550.1 - 2.6 8.3 17.7 2.8 8.2 17.7 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein V_ATPase_I PF01496.19 CDI81550.1 - 2.6 5.9 14.1 2.8 5.8 14.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Eapp_C PF10238.9 CDI81550.1 - 2.7 8.1 14.6 2.9 7.9 14.6 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein EPL1 PF10513.9 CDI81550.1 - 2.9 8.3 15.1 3.2 8.1 15.1 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like UNC-79 PF14776.6 CDI81550.1 - 2.9 6.5 8.7 3.2 6.4 8.7 1.0 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 FAM176 PF14851.6 CDI81550.1 - 2.9 7.5 10.0 3.1 7.5 10.0 1.1 1 0 0 1 1 1 0 FAM176 family Na_K-ATPase PF00287.18 CDI81550.1 - 2.9 7.0 11.4 3.1 6.9 11.4 1.0 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain Ureide_permease PF07168.11 CDI81550.1 - 3 6.5 7.4 3.2 6.4 7.4 1.0 1 0 0 1 1 1 0 Ureide permease DUF3276 PF11680.8 CDI81550.1 - 3.1 7.9 11.1 3.6 7.7 11.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) PIP5K PF01504.18 CDI81550.1 - 3.2 6.9 10.5 3.2 6.9 10.5 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Ctr PF04145.15 CDI81550.1 - 3.2 8.4 6.1 3.2 8.3 6.1 1.0 1 0 0 1 1 1 0 Ctr copper transporter family WRNPLPNID PF15017.6 CDI81550.1 - 3.5 8.6 15.6 5.5 7.9 15.6 1.4 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box CSG2 PF16965.5 CDI81550.1 - 3.8 6.4 6.6 3.9 6.3 6.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4770 PF15994.5 CDI81550.1 - 3.9 7.7 14.6 4.3 7.5 14.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Saw1 PF11561.8 CDI81550.1 - 4.2 6.8 13.3 4.5 6.7 13.3 1.0 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Neur_chan_memb PF02932.16 CDI81550.1 - 4.3 7.3 9.4 4.3 7.3 9.4 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Otopetrin PF03189.13 CDI81550.1 - 4.7 5.9 7.3 4.9 5.9 7.3 1.0 1 0 0 1 1 1 0 Otopetrin Sec62 PF03839.16 CDI81550.1 - 4.8 6.6 9.4 5.1 6.5 9.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 UPF0560 PF10577.9 CDI81550.1 - 4.9 5.5 20.7 4.6 5.6 20.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Orf78 PF06024.12 CDI81550.1 - 5.2 7.4 8.5 6.2 7.2 8.5 1.1 1 0 0 1 1 1 0 Orf78 (ac78) DUF2722 PF10846.8 CDI81550.1 - 5.3 5.9 33.1 5.7 5.8 33.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) HCO3_cotransp PF00955.21 CDI81550.1 - 5.7 5.6 4.5 5.7 5.6 4.5 1.0 1 0 0 1 1 1 0 HCO3- transporter family Paf1 PF03985.13 CDI81550.1 - 5.8 5.8 18.5 6 5.8 18.5 1.0 1 0 0 1 1 1 0 Paf1 Folate_carrier PF01770.18 CDI81550.1 - 5.9 5.5 8.3 5.9 5.5 8.3 1.0 1 0 0 1 1 1 0 Reduced folate carrier Kei1 PF08552.11 CDI81550.1 - 6.2 6.7 7.5 6.6 6.6 7.5 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF2126 PF09899.9 CDI81550.1 - 6.2 4.8 9.6 6.3 4.7 9.6 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) MDM10 PF12519.8 CDI81550.1 - 6.2 5.6 9.9 6.5 5.5 9.9 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF4518 PF15008.6 CDI81550.1 - 6.3 5.9 15.3 7 5.7 15.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) Het-C PF07217.11 CDI81550.1 - 6.5 5.2 10.2 6.6 5.1 10.2 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C MCU PF04678.13 CDI81550.1 - 7 6.7 11.1 7.3 6.6 11.1 1.0 1 0 0 1 1 1 0 Mitochondrial calcium uniporter WASH-7_C PF14746.6 CDI81550.1 - 7.5 6.2 14.1 9.3 5.9 14.1 1.1 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal DUF5321 PF17254.2 CDI81550.1 - 7.6 5.9 17.6 8.9 5.7 17.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5321) EOS1 PF12326.8 CDI81550.1 - 7.7 6.4 7.2 8.2 6.3 7.2 1.1 1 0 0 1 1 1 0 N-glycosylation protein DUF775 PF05603.12 CDI81550.1 - 7.9 6.0 15.1 9.1 5.8 15.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) SID-1_RNA_chan PF13965.6 CDI81550.1 - 9.1 4.6 7.6 9.3 4.5 7.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Rpp20 PF12328.8 CDI81550.1 - 9.1 6.2 15.7 11 6.0 15.7 1.1 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P DUF3043 PF11241.8 CDI81550.1 - 9.6 6.2 10.4 11 6.0 10.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) ORC_WH_C PF18137.1 CDI81550.1 - 9.7 6.3 14.2 11 6.0 14.2 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Oxidored_q6 PF01058.22 CDI81553.1 - 1 9.2 4.4 0.33 10.8 1.4 1.7 1 1 1 2 2 2 0 NADH ubiquinone oxidoreductase, 20 Kd subunit Dishevelled PF02377.15 CDI81553.1 - 6.2 7.2 16.9 1.5 9.3 13.2 1.7 1 1 1 2 2 2 0 Dishevelled specific domain SR-25 PF10500.9 CDI81554.1 - 0.2 11.2 38.3 0.49 10.0 27.8 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Connexin PF00029.19 CDI81554.1 - 0.42 10.3 25.6 0.39 10.4 5.5 2.1 2 0 0 2 2 2 0 Connexin Caldesmon PF02029.15 CDI81554.1 - 0.48 9.1 37.1 0.58 8.9 37.1 1.0 1 0 0 1 1 1 0 Caldesmon SelP_N PF04592.14 CDI81554.1 - 1.6 8.1 45.5 0.084 12.3 26.2 2.1 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF5523 PF17661.1 CDI81554.1 - 1.7 8.3 35.3 0.36 10.5 11.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) DUF3464 PF11947.8 CDI81554.1 - 2.1 8.1 29.3 1.9 8.2 12.1 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Med15 PF09606.10 CDI81554.1 - 3 6.4 60.7 0.065 11.9 30.1 2.0 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal AIF_C PF14721.6 CDI81554.1 - 4.9 7.5 27.2 1.5 9.2 9.8 2.4 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TFB6 PF17110.5 CDI81554.1 - 5.5 6.7 20.4 1.9 8.2 5.4 2.3 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH U1snRNP70_N PF12220.8 CDI81554.1 - 6.7 7.4 28.1 6.4 7.5 12.1 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal EFTUD2 PF16004.5 CDI81554.1 - 7.6 7.1 37.6 2.2 8.9 15.1 2.4 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus NPR1_interact PF15699.5 CDI81554.1 - 9.2 6.9 29.8 9 7.0 11.7 2.5 2 0 0 2 2 2 0 NPR1 interacting RskA PF10099.9 CDI81562.1 - 4.7e-06 27.0 0.2 4.7e-06 27.0 0.2 4.3 1 1 2 3 3 3 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI81562.1 - 0.0013 18.4 21.4 0.0013 18.4 21.4 2.6 2 1 0 2 2 2 2 Spt20 family DUF3439 PF11921.8 CDI81562.1 - 2.3 8.2 14.9 0.28 11.2 1.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) GREB1 PF15782.5 CDI81562.1 - 3.9 4.5 43.0 0.056 10.6 35.5 1.6 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer DUF572 PF04502.13 CDI81562.1 - 5.4 6.6 42.1 0.86 9.2 37.6 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF572) DivIC PF04977.15 CDI81562.1 - 6.9 6.5 43.7 5.5 6.8 0.0 3.5 3 0 0 3 3 3 0 Septum formation initiator RskA PF10099.9 CDI81565.1 - 0.00046 20.5 0.5 0.00056 20.2 0.5 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI81565.1 - 0.0021 17.7 8.4 0.0021 17.7 8.4 2.7 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein CCSAP PF15748.5 CDI81565.1 - 0.0075 16.5 9.0 0.0075 16.5 9.0 2.6 1 1 0 2 2 2 1 Centriole, cilia and spindle-associated ArAE_2_N PF10337.9 CDI81565.1 - 0.12 11.4 2.7 0.13 11.3 2.7 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Macoilin PF09726.9 CDI81565.1 - 0.29 9.7 28.2 0.42 9.1 28.2 1.2 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 CDI81565.1 - 1.7 7.4 22.8 0.83 8.3 7.3 2.1 2 0 0 2 2 2 0 Presenilin PNISR PF15996.5 CDI81565.1 - 6.1 7.1 22.8 2.4 8.4 3.6 2.3 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR TCP PF03634.13 CDI81565.1 - 6.7 7.2 29.2 0.3 11.6 8.3 2.3 2 0 0 2 2 2 0 TCP family transcription factor NAD_binding_8 PF13450.6 CDI81569.1 - 1.4e-08 34.8 0.0 3.7e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDI81569.1 - 1.5e-07 31.3 0.0 3.5e-07 30.1 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase MCRA PF06100.11 CDI81569.1 - 1.3e-05 24.2 0.0 2.4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 MCRA family DUF1645 PF07816.11 CDI81569.1 - 1.3e-05 25.8 3.6 1.3e-05 25.8 3.6 4.0 3 1 0 3 3 2 1 Protein of unknown function (DUF1645) SR-25 PF10500.9 CDI81569.1 - 0.00046 19.9 12.3 0.00046 19.9 12.3 3.6 3 1 0 3 3 2 1 Nuclear RNA-splicing-associated protein NAD_binding_9 PF13454.6 CDI81569.1 - 0.00055 20.0 0.4 0.0014 18.6 0.4 1.8 1 1 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CDI81569.1 - 0.0016 17.6 0.5 0.0023 17.1 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CDI81569.1 - 0.0022 17.3 0.0 0.0032 16.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDI81569.1 - 0.0076 15.6 0.2 0.015 14.7 0.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CDI81569.1 - 0.028 13.7 0.0 0.042 13.1 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 CDI81569.1 - 0.053 12.4 0.0 0.094 11.5 0.0 1.4 1 0 0 1 1 1 0 Tryptophan halogenase DUF4667 PF15700.5 CDI81569.1 - 0.072 13.2 43.0 0.21 11.7 10.9 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4667) Pap_E4 PF02711.14 CDI81569.1 - 0.32 12.0 0.0 0.32 12.0 0.0 4.8 3 2 0 3 3 2 0 E4 protein MACPF PF01823.19 CDI81569.1 - 0.77 9.8 16.2 0.17 12.0 0.4 3.3 3 0 0 3 3 3 0 MAC/Perforin domain AF-4 PF05110.13 CDI81569.1 - 5.8 4.9 54.1 0.0071 14.5 13.6 3.2 3 0 0 3 3 3 0 AF-4 proto-oncoprotein Roughex PF06020.11 CDI81569.1 - 8.1 5.4 18.1 0.3 10.1 2.1 2.2 2 0 0 2 2 2 0 Drosophila roughex protein Suf PF05843.14 CDI81570.1 - 1.9 8.4 5.7 5.5 6.9 0.3 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF4667 PF15700.5 CDI81570.1 - 7.3 6.6 14.1 6.5 6.8 9.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) DUF4834 PF16118.5 CDI81570.1 - 8.4 7.4 7.2 10 7.1 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RskA PF10099.9 CDI81587.1 - 0.0021 18.4 17.1 0.0021 18.4 17.1 7.3 1 1 4 6 6 6 1 Anti-sigma-K factor rskA E7 PF00527.18 CDI81587.1 - 0.0025 18.0 0.8 0.0025 18.0 0.8 6.3 4 1 0 6 6 6 1 E7 protein, Early protein DUF1980 PF09323.10 CDI81588.1 - 0.22 11.4 5.7 0.24 11.3 5.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Dishevelled PF02377.15 CDI81588.1 - 0.25 11.8 14.3 0.29 11.6 14.3 1.1 1 0 0 1 1 1 0 Dishevelled specific domain Connexin PF00029.19 CDI81588.1 - 0.37 10.5 8.4 0.32 10.7 8.4 1.1 1 0 0 1 1 1 0 Connexin SID-1_RNA_chan PF13965.6 CDI81588.1 - 0.58 8.5 2.5 0.56 8.5 2.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 AAT PF03417.16 CDI81588.1 - 0.8 9.4 14.2 0.93 9.1 14.2 1.1 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Peptidase_S15 PF02129.18 CDI81588.1 - 0.85 9.2 12.7 0.96 9.0 12.7 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Serinc PF03348.15 CDI81588.1 - 2 7.3 5.9 2.1 7.2 5.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) eIF-3_zeta PF05091.12 CDI81588.1 - 2 7.3 17.6 1.9 7.4 17.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Helicase_RecD PF05127.14 CDI81588.1 - 2.9 7.7 11.6 3.5 7.5 11.6 1.1 1 0 0 1 1 1 0 Helicase MMR1 PF08505.10 CDI81588.1 - 3.9 7.7 19.9 4.3 7.6 19.9 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Baculo_PP31 PF05311.11 CDI81588.1 - 5.2 6.5 12.9 4.9 6.5 12.9 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) FAM199X PF15814.5 CDI81588.1 - 5.5 6.0 10.0 6.4 5.7 10.0 1.2 1 0 0 1 1 1 0 Protein family FAM199X Presenilin PF01080.17 CDI81588.1 - 5.9 5.5 21.4 6.3 5.5 21.4 1.0 1 0 0 1 1 1 0 Presenilin EOS1 PF12326.8 CDI81588.1 - 6.1 6.7 7.5 6.7 6.6 7.5 1.3 1 0 0 1 1 1 0 N-glycosylation protein Neur_chan_memb PF02932.16 CDI81588.1 - 7.5 6.5 13.7 7.7 6.5 13.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Endostatin PF06482.11 CDI81588.1 - 7.7 5.9 19.8 8.2 5.8 19.8 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF2722 PF10846.8 CDI81594.1 - 3.6e-06 26.2 10.7 3.6e-06 26.2 10.7 7.1 4 1 1 5 5 5 2 Protein of unknown function (DUF2722) DUF45 PF01863.17 CDI81594.1 - 7.4 6.6 26.8 0.03 14.4 4.9 3.4 3 0 0 3 3 3 0 Protein of unknown function DUF45 PSS PF03034.15 CDI81600.1 - 3.8e-74 249.9 16.4 5.5e-74 249.4 16.4 1.2 1 0 0 1 1 1 1 Phosphatidyl serine synthase Saf_2TM PF18303.1 CDI81600.1 - 1 9.0 2.8 2.6 7.6 0.0 2.7 3 0 0 3 3 3 0 SAVED-fused 2TM effector domain NIF PF03031.18 CDI81601.1 - 5.6e-22 78.2 0.0 9.2e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Porin_3 PF01459.22 CDI81602.1 - 1.5e-20 73.8 0.0 2.4e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic porin RskA PF10099.9 CDI81611.1 - 0.00035 20.9 6.8 0.00035 20.9 6.8 3.2 1 1 1 3 3 3 1 Anti-sigma-K factor rskA DUF842 PF05811.13 CDI81611.1 - 0.0039 16.9 3.8 0.0039 16.9 3.8 1.7 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF842) Apt1 PF10351.9 CDI81611.1 - 0.016 14.1 6.5 0.017 14.0 6.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain TFIIA PF03153.13 CDI81611.1 - 0.49 10.3 37.1 0.58 10.1 37.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SPX PF03105.19 CDI81611.1 - 0.71 9.7 15.1 0.96 9.3 15.1 1.2 1 0 0 1 1 1 0 SPX domain Lin-8 PF03353.15 CDI81611.1 - 1.1 8.8 8.8 1.6 8.2 8.8 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Med15 PF09606.10 CDI81611.1 - 1.9 7.1 23.4 2.3 6.8 23.4 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Peptidase_S64 PF08192.11 CDI81611.1 - 5.6 5.3 14.6 7.4 4.9 14.6 1.3 1 0 0 1 1 1 0 Peptidase family S64 PAT1 PF09770.9 CDI81611.1 - 8.3 4.5 19.9 11 4.2 19.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2722 PF10846.8 CDI81612.1 - 0.00053 19.1 9.8 0.00053 19.1 9.8 6.2 2 1 3 5 5 5 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI81612.1 - 0.00092 19.6 18.6 0.00092 19.6 18.6 5.5 2 1 2 4 4 4 2 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI81612.1 - 0.003 17.6 0.0 0.003 17.6 0.0 10.9 3 3 2 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI81612.1 - 0.0038 16.9 19.9 0.0038 16.9 19.9 6.0 2 1 2 4 4 4 1 Spt20 family Pex14_N PF04695.13 CDI81612.1 - 0.0045 17.7 9.6 0.0045 17.7 9.6 4.7 2 1 2 4 4 4 1 Peroxisomal membrane anchor protein (Pex14p) conserved region MMR1 PF08505.10 CDI81612.1 - 0.01 16.1 1.1 0.01 16.1 1.1 4.2 2 1 2 4 4 4 0 Mitochondrial Myo2 receptor-related protein K_channel_TID PF07941.11 CDI81612.1 - 0.032 14.7 16.2 0.032 14.7 16.2 12.0 7 3 2 9 9 9 0 Potassium channel Kv1.4 tandem inactivation domain TPH PF13868.6 CDI81615.1 - 4.4e-14 51.8 62.6 5.3e-14 51.5 62.6 1.0 1 0 0 1 1 1 1 Trichohyalin-plectin-homology domain UPF0004 PF00919.20 CDI81620.1 - 2.8e-11 43.3 3.6 4.9e-05 23.3 0.0 3.7 3 0 0 3 3 3 2 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 CDI81620.1 - 2.5e-07 31.3 0.2 9.8e-07 29.3 0.1 2.1 3 0 0 3 3 1 1 Radical SAM superfamily DUF2722 PF10846.8 CDI81620.1 - 5.9e-06 25.5 2.3 5.9e-06 25.5 2.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) DUF4207 PF13904.6 CDI81620.1 - 0.0049 16.6 6.1 0.0049 16.6 6.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4207) Med15 PF09606.10 CDI81620.1 - 0.014 14.1 13.1 0.022 13.5 13.1 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ribosomal_60s PF00428.19 CDI81620.1 - 0.02 15.5 48.2 0.3 11.7 7.5 4.7 4 0 0 4 4 4 0 60s Acidic ribosomal protein CENP-B_dimeris PF09026.10 CDI81620.1 - 0.051 14.0 4.8 0.2 12.0 4.0 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF775 PF05603.12 CDI81620.1 - 0.054 13.0 4.9 0.12 11.9 4.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Med3 PF11593.8 CDI81620.1 - 0.056 12.6 27.8 0.02 14.1 14.0 2.3 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal CDC45 PF02724.14 CDI81620.1 - 0.088 11.1 8.0 0.88 7.8 0.1 2.1 2 0 0 2 2 2 0 CDC45-like protein Spt20 PF12090.8 CDI81620.1 - 0.11 12.0 22.1 0.24 11.0 22.1 1.4 1 0 0 1 1 1 0 Spt20 family Mit_KHE1 PF10173.9 CDI81620.1 - 0.13 12.4 0.2 21 5.2 0.2 2.8 3 0 0 3 3 3 0 Mitochondrial K+-H+ exchange-related Pex14_N PF04695.13 CDI81620.1 - 0.25 12.0 19.5 0.21 12.2 7.6 2.9 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EPL1 PF10513.9 CDI81620.1 - 0.34 11.3 8.9 1.3 9.4 3.2 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like PBP1_TM PF14812.6 CDI81620.1 - 0.78 10.1 5.3 4.4 7.7 0.6 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal eIF-3_zeta PF05091.12 CDI81620.1 - 1.4 7.8 9.3 0.015 14.3 1.8 1.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RskA PF10099.9 CDI81620.1 - 2.4 8.4 53.4 1.1 9.5 6.6 4.1 1 1 1 2 2 1 0 Anti-sigma-K factor rskA DUF2052 PF09747.9 CDI81620.1 - 3.3 7.8 19.0 2.1 8.4 6.8 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) EOS1 PF12326.8 CDI81620.1 - 3.7 7.4 4.1 7.7 6.4 4.1 1.6 1 1 0 1 1 1 0 N-glycosylation protein Med17 PF10156.9 CDI81620.1 - 5.9 5.5 11.4 4.9 5.7 0.2 2.1 2 0 0 2 2 2 0 Subunit 17 of Mediator complex Neur_chan_memb PF02932.16 CDI81620.1 - 7.7 6.5 5.5 1.6 8.7 0.4 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Activator_LAG-3 PF11498.8 CDI81620.1 - 7.9 5.3 25.8 16 4.3 25.8 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 FAM176 PF14851.6 CDI81620.1 - 9.7 5.8 13.4 8.7 6.0 0.1 2.6 2 1 0 2 2 2 0 FAM176 family Shadoo PF14999.6 CDI81624.1 - 0.0085 16.2 0.6 0.0085 16.2 0.6 3.2 3 0 0 3 3 3 2 Shadow of prion protein, neuroprotective SARAF PF06682.12 CDI81624.1 - 9 5.8 37.4 5.4 6.6 14.9 2.9 1 1 2 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2722 PF10846.8 CDI81628.1 - 0.03 13.3 29.2 0.037 13.0 29.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CobT PF06213.12 CDI81628.1 - 0.048 13.0 15.1 0.046 13.1 15.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT EIIBC-GUT_N PF03612.14 CDI81628.1 - 0.07 12.9 10.0 0.089 12.5 10.0 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus RED_N PF07808.13 CDI81628.1 - 0.12 11.9 11.6 0.13 11.9 11.6 1.2 1 0 0 1 1 1 0 RED-like protein N-terminal region Med15 PF09606.10 CDI81628.1 - 0.18 10.4 24.8 0.16 10.6 24.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4746 PF15928.5 CDI81628.1 - 0.22 10.9 5.2 0.2 11.0 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Activator_LAG-3 PF11498.8 CDI81628.1 - 0.23 10.4 36.8 0.22 10.5 36.8 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.13 CDI81628.1 - 0.24 11.4 32.6 0.24 11.4 32.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 CDI81628.1 - 0.28 9.1 10.0 0.24 9.3 10.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3464 PF11947.8 CDI81628.1 - 0.29 10.9 10.5 0.41 10.4 10.5 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 SpoIIP PF07454.11 CDI81628.1 - 0.35 10.3 14.1 0.37 10.2 14.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RR_TM4-6 PF06459.12 CDI81628.1 - 0.42 10.4 9.8 0.44 10.3 9.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Connexin PF00029.19 CDI81628.1 - 0.5 10.1 10.6 0.58 9.9 10.6 1.1 1 0 0 1 1 1 0 Connexin FCP1_C PF09309.10 CDI81628.1 - 0.7 9.7 16.1 0.8 9.5 16.1 1.0 1 0 0 1 1 1 0 FCP1, C-terminal Tim54 PF11711.8 CDI81628.1 - 0.72 8.6 11.8 0.71 8.6 11.8 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CTNNB1_binding PF08347.11 CDI81628.1 - 0.8 9.9 16.5 0.91 9.7 16.5 1.1 1 0 0 1 1 1 0 N-terminal CTNNB1 binding Peptidase_S49_N PF08496.10 CDI81628.1 - 0.92 9.6 8.6 1.1 9.3 8.6 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PepSY_TM PF03929.16 CDI81628.1 - 0.94 9.1 6.3 0.89 9.2 6.3 1.0 1 0 0 1 1 1 0 PepSY-associated TM region eIF-3_zeta PF05091.12 CDI81628.1 - 1.3 7.9 17.5 1.4 7.8 17.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4770 PF15994.5 CDI81628.1 - 1.3 9.2 15.7 1.6 9.0 15.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) PAT1 PF09770.9 CDI81628.1 - 1.6 6.9 20.8 1.5 7.0 20.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1645 PF07816.11 CDI81628.1 - 1.7 9.2 16.8 2.1 8.9 16.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Lin-8 PF03353.15 CDI81628.1 - 1.8 8.0 21.9 2.1 7.8 21.9 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2828 PF11443.8 CDI81628.1 - 1.8 6.5 12.1 2.1 6.4 12.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Ureide_permease PF07168.11 CDI81628.1 - 2.6 6.7 4.9 2.9 6.5 4.9 1.1 1 0 0 1 1 1 0 Ureide permease CLN3 PF02487.17 CDI81628.1 - 3.1 6.7 9.2 3.3 6.6 9.2 1.2 1 0 0 1 1 1 0 CLN3 protein Zip PF02535.22 CDI81628.1 - 3.5 6.7 6.7 3.8 6.6 6.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FAM176 PF14851.6 CDI81628.1 - 4.7 6.9 11.7 5.1 6.7 11.5 1.2 1 1 0 1 1 1 0 FAM176 family Band_3_cyto PF07565.13 CDI81628.1 - 4.8 6.9 14.5 4.8 6.9 14.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain GOLD_2 PF13897.6 CDI81628.1 - 5 7.6 8.2 4.9 7.6 7.7 1.3 1 1 0 1 1 1 0 Golgi-dynamics membrane-trafficking Pex26 PF07163.12 CDI81628.1 - 5.5 6.2 12.3 6.2 6.0 12.3 1.3 1 0 0 1 1 1 0 Pex26 protein Neur_chan_memb PF02932.16 CDI81628.1 - 5.9 6.9 11.1 6.5 6.7 11.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BORG_CEP PF14957.6 CDI81628.1 - 6.1 8.0 15.7 6.9 7.9 15.7 1.1 1 0 0 1 1 1 0 Cdc42 effector FHIPEP PF00771.20 CDI81628.1 - 6.5 5.1 8.2 6.3 5.1 8.2 1.0 1 0 0 1 1 1 0 FHIPEP family Presenilin PF01080.17 CDI81628.1 - 7.2 5.3 20.2 8.6 5.0 20.2 1.2 1 0 0 1 1 1 0 Presenilin DUF2367 PF10164.9 CDI81628.1 - 8.3 7.0 7.4 11 6.6 7.4 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) G0-G1_switch_2 PF15103.6 CDI81628.1 - 8.6 6.9 11.9 13 6.3 11.9 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 Sin_N PF04801.13 CDI81628.1 - 9.9 5.3 24.5 11 5.1 24.5 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region MAT1 PF06391.13 CDI81632.1 - 0.45 10.3 14.3 0.51 10.1 14.3 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 MPM1 PF17234.2 CDI81632.1 - 0.74 10.1 13.0 0.89 9.8 13.0 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Macoilin PF09726.9 CDI81632.1 - 0.85 8.1 14.0 0.93 8.0 14.0 1.1 1 0 0 1 1 1 0 Macoilin family Spt20 PF12090.8 CDI81632.1 - 1.1 8.8 29.8 1.3 8.6 29.8 1.1 1 0 0 1 1 1 0 Spt20 family Mucin PF01456.17 CDI81632.1 - 1.3 9.0 21.4 2.1 8.4 21.4 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF4820 PF16091.5 CDI81632.1 - 1.4 8.3 9.7 1.8 7.9 9.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF4484 PF14831.6 CDI81632.1 - 2.8 7.9 7.6 3.5 7.6 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) TFIIA PF03153.13 CDI81632.1 - 4.2 7.3 25.5 6.1 6.7 25.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 CDI81632.1 - 6.8 5.6 14.9 7.1 5.5 14.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Hamartin PF04388.12 CDI81632.1 - 8.6 4.9 16.2 8.7 4.9 16.2 1.0 1 0 0 1 1 1 0 Hamartin protein Apt1 PF10351.9 CDI81632.1 - 9.2 5.0 12.6 9.5 4.9 12.6 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain TFB6 PF17110.5 CDI81633.1 - 0.2 11.4 10.1 0.21 11.3 10.1 1.0 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Spt20 PF12090.8 CDI81633.1 - 0.36 10.4 42.2 0.38 10.3 42.2 1.1 1 0 0 1 1 1 0 Spt20 family Pex14_N PF04695.13 CDI81633.1 - 1.1 10.0 25.5 1.1 9.9 25.5 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Eapp_C PF10238.9 CDI81633.1 - 1.8 8.7 16.0 1.8 8.6 16.0 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF4834 PF16118.5 CDI81633.1 - 2.1 9.4 19.6 2.7 9.0 19.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Orf78 PF06024.12 CDI81633.1 - 2.4 8.5 9.4 2.8 8.3 9.4 1.3 1 0 0 1 1 1 0 Orf78 (ac78) DUF4820 PF16091.5 CDI81633.1 - 2.4 7.5 13.3 2.6 7.3 13.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF3408 PF11888.8 CDI81633.1 - 2.4 8.3 17.7 2.5 8.2 17.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) AIF_C PF14721.6 CDI81633.1 - 3.1 8.1 13.1 3.4 8.0 13.1 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FAM176 PF14851.6 CDI81633.1 - 4.1 7.1 9.9 4 7.1 9.9 1.2 1 0 0 1 1 1 0 FAM176 family DUF3984 PF13136.6 CDI81633.1 - 4.2 6.7 16.4 4.8 6.5 16.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) MecA PF05389.12 CDI81633.1 - 4.5 6.8 14.1 4.8 6.7 14.1 1.0 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Rxt3 PF08642.10 CDI81633.1 - 5.1 7.9 9.5 5.6 7.8 9.5 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 TERB2 PF15101.6 CDI81633.1 - 5.2 7.1 23.1 5.8 6.9 23.1 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CPSF100_C PF13299.6 CDI81633.1 - 6.4 6.9 15.1 6.9 6.8 15.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2722 PF10846.8 CDI81633.1 - 7 5.5 36.7 8.5 5.2 36.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF775 PF05603.12 CDI81633.1 - 7.2 6.1 18.4 7.7 6.0 18.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) SpoIIP PF07454.11 CDI81633.1 - 7.6 5.9 18.5 8 5.8 18.5 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) G0-G1_switch_2 PF15103.6 CDI81633.1 - 8.1 6.9 13.7 9.3 6.7 13.7 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 DUF3405 PF11885.8 CDI81633.1 - 8.4 4.9 18.1 9.4 4.7 18.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) Peptidase_U57 PF05582.12 CDI81633.1 - 8.9 5.5 13.2 9.4 5.4 13.2 1.0 1 0 0 1 1 1 0 YabG peptidase U57 DUF4217 PF13959.6 CDI81634.1 - 0.00028 21.1 0.0 0.00084 19.5 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) SUIM_assoc PF16619.5 CDI81634.1 - 0.011 15.8 7.0 0.011 15.8 7.0 5.4 4 2 2 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 DUF2749 PF10907.8 CDI81634.1 - 3.3 7.9 6.3 8.8 6.6 0.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2749) Glutaredoxin PF00462.24 CDI81635.1 - 4.7e-16 58.7 0.0 6e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 CDI81635.1 - 0.0011 18.9 0.0 0.0028 17.7 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin domain DUF836 PF05768.14 CDI81635.1 - 0.0015 18.9 0.1 0.0031 17.9 0.1 1.6 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) DSBA PF01323.20 CDI81635.1 - 0.0056 16.5 0.2 0.11 12.3 0.0 2.0 2 0 0 2 2 2 1 DSBA-like thioredoxin domain Thioredoxin_9 PF14595.6 CDI81635.1 - 0.033 14.0 0.0 0.04 13.7 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_4 PF13462.6 CDI81635.1 - 0.051 13.7 0.3 6.4 6.9 0.4 2.2 1 1 1 2 2 2 0 Thioredoxin Ogr_Delta PF04606.12 CDI81635.1 - 0.078 13.0 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger STI1 PF17830.1 CDI81636.1 - 1.6e-05 24.7 7.1 0.00074 19.4 1.1 2.2 1 1 1 2 2 2 2 STI1 domain GerD PF17898.1 CDI81636.1 - 0.0016 18.4 0.2 0.0023 17.9 0.2 1.2 1 0 0 1 1 1 1 Spore germination GerD central core domain ComC PF03047.14 CDI81636.1 - 0.11 12.3 0.1 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 COMC family RIO1 PF01163.22 CDI81639.1 - 2.9e-46 157.4 0.0 4.8e-46 156.7 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 CDI81639.1 - 4.4e-32 110.1 0.6 1.1e-31 108.9 0.6 1.7 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 CDI81639.1 - 5.4e-09 36.3 2.5 0.0016 18.4 0.3 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CDI81639.1 - 3.9e-06 26.4 0.5 0.00011 21.6 0.5 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family BUD22 PF09073.10 CDI81639.1 - 0.047 13.0 24.1 0.068 12.5 24.1 1.2 1 0 0 1 1 1 0 BUD22 Stork_head PF10264.9 CDI81639.1 - 0.082 13.1 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain Replic_Relax PF13814.6 CDI81639.1 - 0.11 12.6 0.2 0.29 11.2 0.0 1.7 2 0 0 2 2 2 0 Replication-relaxation SDA1 PF05285.12 CDI81639.1 - 3 7.2 24.6 5.8 6.2 24.6 1.4 1 0 0 1 1 1 0 SDA1 TFIIA PF03153.13 CDI81640.1 - 0.013 15.6 15.0 0.016 15.3 15.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PepSY_TM PF03929.16 CDI81640.1 - 2.5 7.7 4.6 4.8 6.8 4.6 1.4 1 0 0 1 1 1 0 PepSY-associated TM region Yip1 PF04893.17 CDI81645.1 - 5.5e-06 26.2 0.1 5.5e-06 26.2 0.1 2.0 2 0 0 2 2 2 1 Yip1 domain Ribosomal_60s PF00428.19 CDI81645.1 - 0.17 12.5 10.5 0.47 11.1 10.5 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein AP2 PF00847.20 CDI81656.1 - 0.0001 22.4 0.0 0.0001 22.4 0.0 3.6 4 0 0 4 4 4 1 AP2 domain Herpes_capsid PF06112.11 CDI81656.1 - 0.0039 17.3 10.9 0.0039 17.3 10.9 6.1 5 1 0 5 5 5 1 Gammaherpesvirus capsid protein ENTH PF01417.20 CDI81666.1 - 9e-09 35.4 0.0 1.4e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 ENTH domain RskA PF10099.9 CDI81667.1 - 0.00053 20.3 11.2 0.00064 20.1 11.2 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI81667.1 - 0.005 16.5 19.0 0.0076 15.9 19.0 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF241 PF03087.14 CDI81667.1 - 0.031 14.1 13.3 0.039 13.8 13.3 1.0 1 0 0 1 1 1 0 Arabidopsis protein of unknown function BAF1_ABF1 PF04684.13 CDI81667.1 - 0.05 12.7 18.8 0.062 12.4 18.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Serinc PF03348.15 CDI81667.1 - 0.09 11.7 13.0 0.096 11.6 13.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4179 PF13786.6 CDI81667.1 - 0.13 12.8 2.3 0.16 12.5 1.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) CAP59_mtransfer PF11735.8 CDI81667.1 - 0.16 11.6 7.2 0.19 11.4 7.2 1.2 1 0 0 1 1 1 0 Cryptococcal mannosyltransferase 1 SMYLE_N PF18615.1 CDI81667.1 - 0.28 10.7 15.6 0.39 10.2 15.6 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain TALPID3 PF15324.6 CDI81667.1 - 0.6 7.7 27.0 0.73 7.4 27.0 1.0 1 0 0 1 1 1 0 Hedgehog signalling target Neur_chan_memb PF02932.16 CDI81667.1 - 1.4 8.9 16.8 1.8 8.5 16.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4667 PF15700.5 CDI81667.1 - 1.5 8.8 28.1 2.1 8.4 28.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) SID-1_RNA_chan PF13965.6 CDI81667.1 - 2 6.7 11.5 2.4 6.5 11.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 CDI81667.1 - 3 6.7 15.2 3.5 6.5 15.2 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Macoilin PF09726.9 CDI81667.1 - 3.1 6.3 21.0 4.3 5.8 21.0 1.3 1 0 0 1 1 1 0 Macoilin family FAM60A PF15396.6 CDI81667.1 - 3.3 7.7 18.6 4.5 7.2 18.6 1.2 1 0 0 1 1 1 0 Protein Family FAM60A AF-4 PF05110.13 CDI81667.1 - 3.5 5.6 33.2 4.2 5.3 33.2 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TFIIA PF03153.13 CDI81667.1 - 4 7.3 45.6 5.9 6.8 45.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI81667.1 - 4.5 5.9 25.1 5.6 5.6 25.1 1.1 1 0 0 1 1 1 0 Presenilin Trp_oprn_chp PF09534.10 CDI81667.1 - 4.9 6.9 10.3 12 5.6 10.3 1.7 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Endostatin PF06482.11 CDI81667.1 - 5.9 6.3 23.5 6.9 6.0 23.5 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin eIF-3_zeta PF05091.12 CDI81667.1 - 6.3 5.7 23.5 7.9 5.3 23.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DcuA_DcuB PF03605.14 CDI81667.1 - 7.6 5.3 9.7 2.4 7.0 7.2 1.4 1 1 1 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Dsh_C PF12316.8 CDI81667.1 - 8.8 6.7 17.9 13 6.1 17.9 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal UPF0231 PF06062.11 CDI81671.1 - 2 8.7 17.2 2.1 8.6 17.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0231) DUF4770 PF15994.5 CDI81671.1 - 9 6.5 19.8 13 6.0 19.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Sin_N PF04801.13 CDI81671.1 - 9.2 5.4 30.3 10 5.2 30.3 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region TRM PF02005.16 CDI81672.1 - 3.4e-34 118.6 6.9 1.7e-20 73.5 0.0 3.4 2 1 1 3 3 3 3 N2,N2-dimethylguanosine tRNA methyltransferase RskA PF10099.9 CDI81672.1 - 1e-09 38.9 3.9 1e-09 38.9 3.9 2.6 1 1 1 2 2 1 1 Anti-sigma-K factor rskA Apt1 PF10351.9 CDI81672.1 - 0.0015 17.5 9.9 0.002 17.1 9.9 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain PNISR PF15996.5 CDI81672.1 - 0.0018 18.6 14.2 0.0037 17.6 14.2 1.5 1 0 0 1 1 1 1 Arginine/serine-rich protein PNISR Borrelia_P83 PF05262.11 CDI81672.1 - 0.0051 15.4 5.8 0.0067 15.0 5.8 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein Ureide_permease PF07168.11 CDI81672.1 - 0.029 13.2 2.7 0.046 12.5 2.7 1.2 1 0 0 1 1 1 0 Ureide permease Plasmodium_Vir PF05795.11 CDI81672.1 - 0.045 13.2 13.4 0.074 12.5 13.4 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF4820 PF16091.5 CDI81672.1 - 0.093 12.1 10.3 0.16 11.3 10.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) GREB1 PF15782.5 CDI81672.1 - 0.1 9.7 20.5 0.15 9.2 20.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer G0-G1_switch_2 PF15103.6 CDI81672.1 - 0.11 13.0 5.1 0.27 11.7 5.1 1.7 1 0 0 1 1 1 0 G0/G1 switch protein 2 BORG_CEP PF14957.6 CDI81672.1 - 0.12 13.6 14.0 0.25 12.5 14.0 1.5 1 0 0 1 1 1 0 Cdc42 effector Miga PF10265.9 CDI81672.1 - 0.16 10.9 14.9 0.26 10.2 14.9 1.2 1 0 0 1 1 1 0 Mitoguardin SID-1_RNA_chan PF13965.6 CDI81672.1 - 0.32 9.3 3.2 0.42 9.0 3.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Macoilin PF09726.9 CDI81672.1 - 0.42 9.1 20.4 0.68 8.4 20.4 1.2 1 0 0 1 1 1 0 Macoilin family SpoIIP PF07454.11 CDI81672.1 - 0.49 9.8 15.3 0.73 9.2 15.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PAT1 PF09770.9 CDI81672.1 - 0.54 8.5 20.0 0.81 7.9 20.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Spt20 PF12090.8 CDI81672.1 - 0.67 9.5 42.4 1.4 8.5 42.4 1.5 1 0 0 1 1 1 0 Spt20 family DUF35_N PF12172.8 CDI81672.1 - 0.96 9.4 6.3 1.2 9.1 0.3 2.4 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF1645 PF07816.11 CDI81672.1 - 1 9.9 27.2 0.13 12.8 16.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1645) PTPRCAP PF15713.5 CDI81672.1 - 1.1 9.5 26.7 2.2 8.6 26.7 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF2722 PF10846.8 CDI81672.1 - 1.1 8.1 32.3 2.4 7.0 32.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) FHIPEP PF00771.20 CDI81672.1 - 1.2 7.5 4.3 1.9 6.9 4.3 1.3 1 0 0 1 1 1 0 FHIPEP family GNAT_acetyltr_2 PF13718.6 CDI81672.1 - 1.3 8.4 8.3 2.1 7.7 8.3 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 eIF-3_zeta PF05091.12 CDI81672.1 - 1.5 7.7 19.5 2.1 7.2 19.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Med15 PF09606.10 CDI81672.1 - 1.6 7.3 30.1 0.024 13.4 22.6 1.6 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Lin-8 PF03353.15 CDI81672.1 - 1.6 8.2 25.0 3 7.3 25.0 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4746 PF15928.5 CDI81672.1 - 1.9 7.8 13.8 3 7.2 13.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PAP1 PF08601.10 CDI81672.1 - 2.3 7.9 27.6 1.8 8.2 20.3 2.1 2 0 0 2 2 2 0 Transcription factor PAP1 CSG2 PF16965.5 CDI81672.1 - 2.3 7.1 5.8 3.6 6.4 5.8 1.4 1 0 0 1 1 1 0 Ceramide synthase regulator Otopetrin PF03189.13 CDI81672.1 - 2.6 6.7 5.8 3.7 6.2 5.8 1.2 1 0 0 1 1 1 0 Otopetrin CobT PF06213.12 CDI81672.1 - 2.7 7.3 26.8 5.2 6.4 26.8 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Tim54 PF11711.8 CDI81672.1 - 2.9 6.6 14.2 4.8 5.9 14.2 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PA26 PF04636.13 CDI81672.1 - 3 6.7 10.1 4.2 6.2 10.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Connexin PF00029.19 CDI81672.1 - 3.4 7.4 11.4 5 6.8 11.4 1.2 1 0 0 1 1 1 0 Connexin Cwf_Cwc_15 PF04889.12 CDI81672.1 - 3.4 7.3 25.4 6 6.5 25.4 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein EIIBC-GUT_N PF03612.14 CDI81672.1 - 3.4 7.4 10.9 6.4 6.5 10.9 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus PBP1_TM PF14812.6 CDI81672.1 - 4 7.9 11.4 7.5 7.0 11.4 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3306 PF11748.8 CDI81672.1 - 4.2 8.3 20.9 23 5.9 16.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Presenilin PF01080.17 CDI81672.1 - 4.2 6.0 25.3 7.4 5.2 25.3 1.3 1 0 0 1 1 1 0 Presenilin XRCC4 PF06632.12 CDI81672.1 - 4.3 6.1 16.7 8.1 5.2 16.7 1.4 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 SR-25 PF10500.9 CDI81672.1 - 4.6 6.8 38.2 0.037 13.6 29.8 1.7 2 0 0 2 2 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 CDI81672.1 - 4.8 7.5 35.9 10 6.4 35.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Folate_carrier PF01770.18 CDI81672.1 - 4.8 5.8 5.6 6.8 5.3 5.6 1.2 1 0 0 1 1 1 0 Reduced folate carrier TMEM51 PF15345.6 CDI81672.1 - 5.1 6.9 17.9 12 5.6 17.9 1.6 1 0 0 1 1 1 0 Transmembrane protein 51 Serinc PF03348.15 CDI81672.1 - 6 5.7 7.6 8.2 5.2 7.6 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4770 PF15994.5 CDI81672.1 - 7 6.9 13.0 12 6.1 13.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) PI3K_1B_p101 PF10486.9 CDI81672.1 - 7 4.3 18.0 10 3.7 18.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF572 PF04502.13 CDI81672.1 - 7 6.2 19.6 1.7 8.2 16.3 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF572) CBP_BcsG PF11658.8 CDI81672.1 - 8.1 4.7 8.2 13 4.0 8.2 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG MPM1 PF17234.2 CDI81672.1 - 9.6 6.4 20.1 19 5.5 20.1 1.5 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Collagen PF01391.18 CDI81673.1 - 3.4e-05 23.5 25.7 3.4e-05 23.5 25.7 3.5 5 0 0 5 5 5 1 Collagen triple helix repeat (20 copies) Cpn60_TCP1 PF00118.24 CDI81679.1 - 1.3e-07 30.7 0.1 1.3e-07 30.7 0.1 1.4 2 0 0 2 2 1 1 TCP-1/cpn60 chaperonin family MecA PF05389.12 CDI81679.1 - 0.0095 15.6 1.0 0.011 15.4 1.0 1.0 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) LIM_bind PF01803.16 CDI81679.1 - 0.012 15.2 3.8 0.018 14.6 3.8 1.2 1 0 0 1 1 1 0 LIM-domain binding protein Suf PF05843.14 CDI81679.1 - 0.019 15.0 7.1 0.022 14.8 7.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Saw1 PF11561.8 CDI81679.1 - 0.019 14.5 4.3 0.022 14.3 4.3 1.0 1 0 0 1 1 1 0 Single strand annealing-weakened 1 DUF4834 PF16118.5 CDI81679.1 - 0.025 15.5 5.0 0.039 14.9 5.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI81679.1 - 0.032 13.9 20.9 0.033 13.8 20.9 1.2 1 0 0 1 1 1 0 Spt20 family DcuA_DcuB PF03605.14 CDI81679.1 - 0.043 12.7 0.2 0.049 12.5 0.2 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Peroxin-13_N PF04088.13 CDI81679.1 - 0.052 13.8 1.2 0.058 13.7 1.2 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region SHR3_chaperone PF08229.11 CDI81679.1 - 0.053 12.5 6.1 0.062 12.3 6.1 1.1 1 0 0 1 1 1 0 ER membrane protein SH3 Rsm1 PF08600.10 CDI81679.1 - 0.053 13.7 4.4 0.054 13.6 3.1 1.6 1 1 1 2 2 2 0 Rsm1-like DUF719 PF05334.13 CDI81679.1 - 0.059 13.6 4.0 0.11 12.7 4.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF719) DDHD PF02862.17 CDI81679.1 - 0.15 12.2 3.1 0.17 12.0 3.1 1.1 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 CDI81679.1 - 0.18 10.6 3.6 0.18 10.5 3.6 1.1 1 0 0 1 1 1 0 Presenilin PigN PF04987.14 CDI81679.1 - 0.22 10.3 1.6 0.23 10.3 1.6 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) CSG2 PF16965.5 CDI81679.1 - 0.24 10.3 0.8 0.27 10.1 0.8 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator TFIIA PF03153.13 CDI81679.1 - 0.25 11.3 21.6 0.3 11.1 21.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF5327 PF17261.2 CDI81679.1 - 0.29 11.9 12.6 0.41 11.4 12.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5327) ALMT PF11744.8 CDI81679.1 - 0.31 9.8 4.0 0.35 9.6 4.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter FliP PF00813.20 CDI81679.1 - 1.2 8.9 3.8 1.7 8.5 3.8 1.2 1 0 0 1 1 1 0 FliP family MscS_TM PF12794.7 CDI81679.1 - 1.6 7.5 10.3 1.5 7.6 9.8 1.3 1 1 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 RNA_pol_Rpo13 PF12136.8 CDI81681.1 - 1.1 9.2 12.4 1.9 8.4 12.4 1.4 1 0 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain Caldesmon PF02029.15 CDI81681.1 - 2.3 6.9 70.5 0.24 10.1 49.1 2.6 2 0 0 2 2 2 0 Caldesmon SPX PF03105.19 CDI81684.1 - 0.00021 21.3 8.1 0.0029 17.6 8.1 2.1 1 1 0 1 1 1 1 SPX domain BUD22 PF09073.10 CDI81684.1 - 0.0005 19.5 4.3 0.0005 19.5 4.3 2.1 2 1 0 2 2 2 1 BUD22 DUF4834 PF16118.5 CDI81684.1 - 0.042 14.8 0.2 3.4 8.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Apt1 PF10351.9 CDI81684.1 - 1.5 7.6 17.5 0.35 9.7 14.2 1.5 2 0 0 2 2 2 0 Golgi-body localisation protein domain Spt20 PF12090.8 CDI81684.1 - 2.2 7.8 11.1 0.072 12.7 1.3 2.2 2 0 0 2 2 2 0 Spt20 family DUF4614 PF15391.6 CDI81684.1 - 3.2 7.7 24.0 0.071 13.1 16.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Tmemb_cc2 PF10267.9 CDI81684.1 - 5.2 6.1 8.5 0.86 8.7 3.5 2.0 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein ANAPC1 PF12859.7 CDI81684.1 - 6.9 7.2 12.8 1.9 9.1 8.3 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 SARAF PF06682.12 CDI81684.1 - 9 5.8 12.9 25 4.4 11.0 2.1 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis SPX PF03105.19 CDI81688.1 - 0.00024 21.2 25.2 0.00067 19.7 14.1 2.1 2 0 0 2 2 2 2 SPX domain EPL1 PF10513.9 CDI81688.1 - 0.0072 16.7 13.2 0.066 13.6 3.7 2.2 2 0 0 2 2 2 2 Enhancer of polycomb-like SOG2 PF10428.9 CDI81688.1 - 0.015 14.5 28.6 0.0058 15.9 17.5 2.2 2 0 0 2 2 2 0 RAM signalling pathway protein Velvet PF11754.8 CDI81688.1 - 0.082 12.8 16.8 0.22 11.4 5.3 2.4 2 0 0 2 2 2 0 Velvet factor TCP PF03634.13 CDI81688.1 - 0.17 12.5 20.1 0.28 11.7 0.8 2.5 2 0 0 2 2 2 0 TCP family transcription factor Apt1 PF10351.9 CDI81688.1 - 0.19 10.5 32.2 0.059 12.2 19.8 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Roughex PF06020.11 CDI81688.1 - 0.21 10.6 9.7 0.45 9.6 9.7 1.5 1 0 0 1 1 1 0 Drosophila roughex protein Ndc1_Nup PF09531.10 CDI81688.1 - 0.23 10.1 20.3 0.98 8.0 8.9 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup PI3K_1B_p101 PF10486.9 CDI81688.1 - 0.26 9.0 20.7 0.071 10.9 1.0 2.2 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF3807 PF12720.7 CDI81688.1 - 0.3 11.3 18.3 0.21 11.9 7.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) DUF572 PF04502.13 CDI81688.1 - 0.39 10.3 18.8 0.48 10.0 3.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) Hid1 PF12722.7 CDI81688.1 - 0.52 8.4 19.2 0.6 8.2 6.6 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein NUP214 PF16755.5 CDI81688.1 - 0.76 9.0 4.2 3.3 6.8 4.1 1.7 1 1 1 2 2 2 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 SLC12 PF03522.15 CDI81688.1 - 1.3 7.9 14.5 0.44 9.5 3.5 2.1 2 0 0 2 2 2 0 Solute carrier family 12 SAPS PF04499.15 CDI81688.1 - 2.2 7.0 12.8 1.3 7.7 0.9 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.16 CDI81688.1 - 4.2 7.4 16.9 1.7 8.7 4.8 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Coilin_N PF15862.5 CDI81688.1 - 5.1 6.9 21.8 7.5 6.4 6.7 2.3 2 0 0 2 2 2 0 Coilin N-terminus Gti1_Pac2 PF09729.9 CDI81688.1 - 8.5 6.4 22.5 4.5 7.3 3.6 2.3 2 0 0 2 2 2 0 Gti1/Pac2 family Zip PF02535.22 CDI81688.1 - 9.7 5.3 14.2 1.4 8.0 3.8 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Tr-sialidase_C PF11052.8 CDI81691.1 - 0.012 15.7 4.1 0.03 14.4 4.1 1.7 1 0 0 1 1 1 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal Apt1 PF10351.9 CDI81691.1 - 0.71 8.7 9.5 0.91 8.3 9.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF1117 PF06547.12 CDI81691.1 - 1.2 9.7 6.6 1.6 9.3 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) Secretin_N_2 PF07655.13 CDI81691.1 - 1.8 9.1 19.5 1.2 9.7 9.2 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain EIF4E-T PF10477.9 CDI81704.1 - 1.4 7.6 37.6 2 7.1 37.6 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E PIP5K PF01504.18 CDI81704.1 - 2 7.6 12.6 11 5.1 12.6 2.0 1 1 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase CCSAP PF15748.5 CDI81704.1 - 4.5 7.4 29.2 0.56 10.3 16.9 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Med26_C PF15693.5 CDI81704.1 - 7.5 6.7 29.5 0.15 12.2 7.7 2.4 2 0 0 2 2 2 0 Mediator complex subunit 26 C-terminal DUF5327 PF17261.2 CDI81705.1 - 0.0043 17.8 8.3 0.0043 17.8 8.3 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5327) Spt20 PF12090.8 CDI81705.1 - 0.022 14.4 12.9 0.021 14.4 12.9 1.1 1 0 0 1 1 1 0 Spt20 family DUF3319 PF11782.8 CDI81705.1 - 0.039 13.9 0.1 0.051 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3319) Androgen_recep PF02166.16 CDI81705.1 - 0.072 11.9 9.3 0.074 11.9 9.3 1.0 1 0 0 1 1 1 0 Androgen receptor CDH1_2_SANT_HL1 PF18375.1 CDI81705.1 - 0.1 13.3 2.9 0.13 12.9 2.9 1.3 1 1 0 1 1 1 0 CDH1/2 SANT-Helical linker 1 PID_2 PF14719.6 CDI81705.1 - 0.13 12.1 1.4 0.14 12.0 1.4 1.1 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Atg14 PF10186.9 CDI81705.1 - 0.16 11.0 5.6 0.18 10.8 5.6 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3499 PF12005.8 CDI81705.1 - 0.21 12.2 3.0 0.24 12.0 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3499) DUF4407 PF14362.6 CDI81705.1 - 1.4 8.2 9.7 1.6 8.0 9.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SUIM_assoc PF16619.5 CDI81705.1 - 1.8 8.7 22.6 1.5e+02 2.5 22.6 2.2 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 CDI81705.1 - 2.1 7.2 13.5 2.3 7.1 13.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) GTA_holin_3TM PF11351.8 CDI81705.1 - 7.9 7.0 7.5 8.4 7.0 7.5 1.1 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release DUF2452 PF10504.9 CDI81708.1 - 0.053 13.0 0.1 0.069 12.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) Peptidase_C1 PF00112.23 CDI81710.1 - 3.6e-50 171.1 1.9 5.6e-50 170.4 1.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 CDI81710.1 - 0.026 14.4 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 CDI81710.1 - 0.57 8.9 1.9 8.8 5.0 0.0 2.1 2 0 0 2 2 2 0 Peptidase C1-like family DEAD PF00270.29 CDI81711.1 - 1.5e-14 54.1 0.0 2.6e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI81711.1 - 7.4e-07 29.5 0.0 3e-06 27.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain KdgT PF03812.13 CDI81711.1 - 2.4 7.4 6.0 3.9 6.7 6.0 1.2 1 0 0 1 1 1 0 2-keto-3-deoxygluconate permease ERCC3_RAD25_C PF16203.5 CDI81713.1 - 6.8e-17 61.5 0.1 8.9e-17 61.1 0.1 1.1 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C PF00271.31 CDI81713.1 - 0.00022 21.6 0.1 0.0003 21.1 0.1 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PAP_PilO PF06864.12 CDI81723.1 - 0.059 12.2 10.6 0.066 12.0 10.6 1.0 1 0 0 1 1 1 0 Pilin accessory protein (PilO) DUF5427 PF10310.9 CDI81723.1 - 0.21 10.5 16.7 0.25 10.3 16.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) RR_TM4-6 PF06459.12 CDI81723.1 - 0.24 11.2 14.9 0.32 10.8 14.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TYW3 PF02676.14 CDI81723.1 - 0.34 10.2 7.7 0.38 10.1 7.7 1.1 1 0 0 1 1 1 0 Methyltransferase TYW3 SARAF PF06682.12 CDI81723.1 - 0.34 10.5 16.0 0.44 10.2 16.0 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis EphA2_TM PF14575.6 CDI81723.1 - 0.47 11.4 16.9 0.18 12.7 4.6 2.2 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain V_ATPase_I PF01496.19 CDI81723.1 - 0.52 8.2 16.5 0.54 8.1 16.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3801 PF12687.7 CDI81723.1 - 0.99 9.5 18.4 1.2 9.2 18.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) INSIG PF07281.12 CDI81723.1 - 1 9.0 3.5 1.2 8.8 3.5 1.1 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) ATP11 PF06644.11 CDI81723.1 - 1.2 8.8 16.8 1.8 8.3 16.8 1.2 1 0 0 1 1 1 0 ATP11 protein Serinc PF03348.15 CDI81723.1 - 1.5 7.7 9.5 1.7 7.5 9.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF3807 PF12720.7 CDI81723.1 - 2 8.7 22.8 2.9 8.1 22.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) AP3D1 PF06375.11 CDI81723.1 - 2 8.6 18.7 3 8.1 18.7 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Dehydrin PF00257.19 CDI81723.1 - 3.3 8.2 18.8 7.8 7.0 18.8 1.6 1 1 0 1 1 1 0 Dehydrin ATP19 PF11022.8 CDI81723.1 - 3.3 8.1 6.0 3.9 7.9 1.5 2.5 1 1 1 2 2 2 0 ATP synthase subunit K GAGA_bind PF06217.12 CDI81723.1 - 3.3 7.9 18.2 3.9 7.7 18.2 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family CcmD PF04995.14 CDI81723.1 - 3.5 7.8 21.0 0.89 9.7 3.7 2.2 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) PepSY_TM PF03929.16 CDI81723.1 - 3.9 7.0 5.6 4.5 6.8 5.6 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Glycogen_syn PF05693.13 CDI81723.1 - 5.7 5.4 8.4 5.9 5.3 8.4 1.0 1 0 0 1 1 1 0 Glycogen synthase Sec62 PF03839.16 CDI81723.1 - 6.4 6.2 14.9 8.7 5.8 14.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 ATP-synt_E PF05680.12 CDI81723.1 - 6.8 7.1 17.1 0.15 12.4 3.9 2.1 2 0 0 2 2 2 0 ATP synthase E chain Presenilin PF01080.17 CDI81723.1 - 6.9 5.3 23.9 8.4 5.0 23.9 1.0 1 0 0 1 1 1 0 Presenilin Lin-8 PF03353.15 CDI81723.1 - 7.2 6.1 23.1 8.6 5.8 23.1 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DDHD PF02862.17 CDI81723.1 - 7.5 6.6 19.0 11 6.0 19.0 1.2 1 0 0 1 1 1 0 DDHD domain DUF2828 PF11443.8 CDI81723.1 - 7.7 4.5 15.2 8.8 4.3 15.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CLN3 PF02487.17 CDI81723.1 - 7.8 5.4 13.0 9.5 5.1 13.0 1.2 1 0 0 1 1 1 0 CLN3 protein 7tm_2 PF00002.24 CDI81723.1 - 8.7 5.5 6.3 3.4 6.9 3.6 1.6 1 1 1 2 2 2 0 7 transmembrane receptor (Secretin family) GET2 PF08690.10 CDI81723.1 - 8.7 5.9 24.9 10 5.7 24.9 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 DUF4667 PF15700.5 CDI81724.1 - 0.012 15.7 2.1 0.012 15.7 2.1 4.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4667) DUF572 PF04502.13 CDI81724.1 - 1.3 8.6 38.2 0.43 10.2 1.2 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF572) DUF3295 PF11702.8 CDI81731.1 - 0.00027 20.4 9.2 0.00027 20.4 9.2 3.0 2 1 0 2 2 2 1 Protein of unknown function (DUF3295) Hamartin PF04388.12 CDI81731.1 - 0.19 10.3 36.3 0.059 12.1 19.5 2.2 2 0 0 2 2 2 0 Hamartin protein BAF1_ABF1 PF04684.13 CDI81731.1 - 0.22 10.5 33.4 0.11 11.6 1.8 2.3 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor SMYLE_N PF18615.1 CDI81731.1 - 0.5 9.9 33.2 1.3 8.5 6.9 2.2 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Zip PF02535.22 CDI81731.1 - 1.3 8.2 22.0 4.8 6.3 0.4 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter Lin-8 PF03353.15 CDI81733.1 - 0.0081 15.8 21.8 0.0089 15.6 21.8 1.2 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist PI3K_1B_p101 PF10486.9 CDI81733.1 - 0.11 10.2 23.3 0.13 10.0 23.3 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF1645 PF07816.11 CDI81733.1 - 0.32 11.6 25.9 0.45 11.1 25.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) SPX PF03105.19 CDI81733.1 - 0.63 9.9 24.4 0.72 9.7 24.4 1.1 1 0 0 1 1 1 0 SPX domain Peptidase_S64 PF08192.11 CDI81733.1 - 0.97 7.8 30.1 1.1 7.7 30.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Auxin_canalis PF05703.11 CDI81733.1 - 1.5 8.7 40.7 1.8 8.4 40.7 1.1 1 0 0 1 1 1 0 Auxin canalisation Apt1 PF10351.9 CDI81733.1 - 2.1 7.1 24.4 2.4 6.9 24.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Plasmodium_Vir PF05795.11 CDI81733.1 - 2.1 7.7 15.4 2.5 7.5 15.4 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SLC12 PF03522.15 CDI81733.1 - 4.8 6.1 24.0 5.9 5.8 24.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Mucin15 PF15672.5 CDI81733.1 - 8.5 5.8 15.2 9.8 5.6 15.2 1.1 1 0 0 1 1 1 0 Cell-membrane associated Mucin15 SR-25 PF10500.9 CDI81733.1 - 9.9 5.7 42.2 51 3.4 41.9 2.0 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI81737.1 - 2.2 8.2 21.8 2.3 8.1 21.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI81737.1 - 3 6.4 25.4 3.2 6.3 25.4 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Dehydrin PF00257.19 CDI81737.1 - 4.1 7.9 11.3 5.1 7.6 11.3 1.1 1 0 0 1 1 1 0 Dehydrin R_equi_Vir PF05526.11 CDI81737.1 - 8 6.3 12.2 9.7 6.0 12.2 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein SR-25 PF10500.9 CDI81738.1 - 0.0049 16.5 1.5 0.0049 16.5 1.5 2.7 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI81738.1 - 0.013 15.5 11.4 1 9.5 5.7 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Secretin_N_2 PF07655.13 CDI81738.1 - 0.52 10.9 8.8 4 8.1 0.3 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain BRF1 PF07741.13 CDI81738.1 - 0.62 10.4 3.8 1.5 9.2 1.1 2.5 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Transposase_24 PF03004.14 CDI81738.1 - 3.6 7.7 9.8 3.9 7.6 0.3 2.9 3 0 0 3 3 3 0 Plant transposase (Ptta/En/Spm family) VTC PF09359.10 CDI81748.1 - 6.7e-82 275.0 0.0 1e-81 274.4 0.0 1.3 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 CDI81748.1 - 3.4e-05 24.2 0.5 0.0001 22.6 0.5 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 CDI81748.1 - 0.00054 20.0 7.6 0.0019 18.2 2.8 2.9 2 1 0 2 2 2 1 SPX domain HAUS6_N PF14661.6 CDI81749.1 - 0.079 12.5 1.4 0.1 12.2 1.4 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus PDDEXK_6 PF04720.12 CDI81749.1 - 0.085 12.8 0.7 0.11 12.4 0.7 1.1 1 0 0 1 1 1 0 PDDEXK-like family of unknown function DUF2400 PF09674.10 CDI81749.1 - 0.15 12.1 0.1 0.2 11.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) Ribosomal_S2 PF00318.20 CDI81749.1 - 0.17 11.1 1.8 0.25 10.6 1.8 1.1 1 0 0 1 1 1 0 Ribosomal protein S2 Fib_alpha PF08702.10 CDI81749.1 - 0.24 11.6 4.6 0.35 11.0 4.6 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF948 PF06103.11 CDI81749.1 - 0.3 11.4 1.5 0.49 10.7 1.5 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Ribosomal_L6 PF00347.23 CDI81750.1 - 1.5e-22 80.0 0.5 1.3e-11 45.0 0.0 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 CENP-W PF15510.6 CDI81750.1 - 0.071 13.3 0.7 3 8.1 0.1 2.4 2 0 0 2 2 2 0 CENP-W protein DnaJ PF00226.31 CDI81751.1 - 2.2e-08 34.1 0.0 6.9e-08 32.5 0.0 1.9 1 0 0 1 1 1 1 DnaJ domain SUIM_assoc PF16619.5 CDI81751.1 - 0.011 15.7 0.0 0.011 15.7 0.0 11.8 7 3 2 9 9 9 0 Unstructured region C-term to UIM in Ataxin3 TPR_2 PF07719.17 CDI81751.1 - 0.26 11.5 7.0 0.54 10.5 2.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Nup54 PF13874.6 CDI81754.1 - 1 9.5 8.3 0.33 11.1 2.7 2.5 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Mito_carr PF00153.27 CDI81755.1 - 1e-38 131.1 2.3 4.2e-16 58.6 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein KH_1 PF00013.29 CDI81756.1 - 0.021 14.6 0.0 1.4 8.8 0.0 2.6 2 0 0 2 2 2 0 KH domain RNA_pol_Rpb4 PF03874.16 CDI81757.1 - 1.4e-07 31.8 0.0 1.4e-07 31.8 0.0 3.8 3 1 0 3 3 3 1 RNA polymerase Rpb4 TT_ORF2 PF02957.15 CDI81758.1 - 1.2 10.0 8.4 0.52 11.2 4.4 2.4 2 0 0 2 2 2 0 TT viral ORF2 Spt20 PF12090.8 CDI81758.1 - 4.9 6.7 21.5 0.49 10.0 13.8 2.1 2 0 0 2 2 2 0 Spt20 family Retrotrans_gag PF03732.17 CDI81760.1 - 0.11 12.8 0.4 0.23 11.7 0.0 1.8 2 0 0 2 2 2 0 Retrotransposon gag protein RT_RNaseH_2 PF17919.1 CDI81762.1 - 3.1e-24 84.9 0.1 5.8e-24 84.0 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI81762.1 - 4.7e-22 78.3 0.0 8.4e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDI81762.1 - 1.2e-16 60.9 0.0 2.2e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Caenor_Her-1 PF09232.10 CDI81762.1 - 0.33 11.1 1.2 19 5.4 0.0 2.2 1 1 1 2 2 2 0 Caenorhabditis elegans Her-1 rve PF00665.26 CDI81763.1 - 1.7e-15 57.2 0.0 2.6e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain SecM PF06558.12 CDI81763.1 - 0.0081 16.3 0.1 0.014 15.5 0.1 1.6 1 0 0 1 1 1 1 Secretion monitor precursor protein (SecM) rve_3 PF13683.6 CDI81763.1 - 0.0094 15.7 0.3 0.26 11.1 0.1 2.2 2 0 0 2 2 2 1 Integrase core domain DUF2870 PF11069.8 CDI81765.1 - 1.1e-17 64.2 0.4 4.5e-10 39.8 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF2870) GlnD_UR_UTase PF08335.11 CDI81765.1 - 0.074 13.1 0.7 2.3 8.3 0.0 2.4 2 0 0 2 2 2 0 GlnD PII-uridylyltransferase TetR_C_15 PF17918.1 CDI81765.1 - 0.64 10.8 4.5 19 6.0 0.2 3.1 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain PDZ_3 PF17815.1 CDI81767.1 - 7.1e-27 94.1 0.4 2.5e-26 92.3 0.2 2.1 2 0 0 2 2 2 1 PDZ domain Trypsin PF00089.26 CDI81767.1 - 1.9e-06 27.9 0.6 0.0068 16.2 0.2 2.9 3 0 0 3 3 3 2 Trypsin Trypsin_2 PF13365.6 CDI81767.1 - 4.7e-05 24.3 11.1 0.00018 22.5 1.8 4.4 3 1 0 3 3 3 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 CDI81767.1 - 0.00043 20.6 0.2 0.0015 18.8 0.0 2.0 2 0 0 2 2 2 1 PDZ domain Cornifin PF02389.15 CDI81767.1 - 0.4 10.9 25.1 2 8.6 25.1 2.3 1 0 0 1 1 1 0 Cornifin (SPRR) family GN3L_Grn1 PF08701.11 CDI81768.1 - 6e-18 64.7 19.3 6e-18 64.7 19.3 3.8 3 2 0 3 3 3 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 CDI81768.1 - 1.3e-16 60.7 0.7 7.9e-14 51.7 0.0 2.9 3 0 0 3 3 3 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CDI81768.1 - 6.1e-09 35.6 0.0 4.9e-06 26.2 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDI81768.1 - 0.00024 21.1 2.2 0.058 13.3 0.2 3.3 3 0 0 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 CDI81768.1 - 0.0018 18.7 0.1 0.0018 18.7 0.1 3.8 4 1 0 4 4 4 1 AAA ATPase domain Mucin15 PF15672.5 CDI81768.1 - 0.034 13.6 2.0 0.085 12.3 2.0 1.6 1 0 0 1 1 1 0 Cell-membrane associated Mucin15 GTP_EFTU PF00009.27 CDI81768.1 - 0.038 13.5 4.5 0.17 11.4 0.0 3.5 4 1 1 5 5 5 0 Elongation factor Tu GTP binding domain MeaB PF03308.16 CDI81768.1 - 0.89 8.5 4.9 0.13 11.2 0.1 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 CDI81768.1 - 1.1 9.3 16.9 0.8 9.7 0.1 4.6 3 2 1 4 4 4 0 Dynamin family RRM_1 PF00076.22 CDI81771.1 - 2e-20 72.4 0.0 4.8e-08 32.7 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EB1 PF03271.17 CDI81775.1 - 6.8e-12 45.4 0.1 6.8e-12 45.4 0.1 1.9 2 0 0 2 2 2 1 EB1-like C-terminal motif Apt1 PF10351.9 CDI81775.1 - 3.5e-05 22.8 10.0 4.4e-05 22.5 10.0 1.0 1 0 0 1 1 1 1 Golgi-body localisation protein domain TFIIA PF03153.13 CDI81775.1 - 0.0019 18.3 22.3 0.002 18.2 22.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CDI81775.1 - 0.0082 15.7 9.6 0.0085 15.7 9.6 1.2 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist Spt20 PF12090.8 CDI81775.1 - 0.018 14.6 21.0 0.028 14.1 21.0 1.2 1 0 0 1 1 1 0 Spt20 family CbiD PF01888.17 CDI81775.1 - 0.038 13.3 9.9 0.98 8.7 0.2 2.1 2 0 0 2 2 2 0 CbiD SPX PF03105.19 CDI81775.1 - 0.057 13.3 14.8 0.061 13.2 14.8 1.1 1 0 0 1 1 1 0 SPX domain SR-25 PF10500.9 CDI81775.1 - 0.12 12.0 38.9 0.064 12.9 37.0 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 CDI81775.1 - 0.13 10.8 16.0 0.14 10.7 16.0 1.2 1 0 0 1 1 1 0 Macoilin family FCP1_C PF09309.10 CDI81775.1 - 0.2 11.5 17.6 0.28 11.0 17.6 1.2 1 0 0 1 1 1 0 FCP1, C-terminal PAP1 PF08601.10 CDI81775.1 - 0.24 11.1 24.8 0.27 10.9 24.8 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Use1 PF09753.9 CDI81775.1 - 0.25 11.0 11.3 0.36 10.5 11.3 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 Ndc1_Nup PF09531.10 CDI81775.1 - 0.25 10.0 16.3 0.29 9.8 16.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TAF4 PF05236.14 CDI81775.1 - 0.41 10.4 16.6 0.57 9.9 16.6 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family PA26 PF04636.13 CDI81775.1 - 0.43 9.4 5.6 0.53 9.1 5.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PNISR PF15996.5 CDI81775.1 - 0.45 10.7 15.7 0.66 10.2 15.7 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Miga PF10265.9 CDI81775.1 - 1.1 8.1 14.6 1.3 7.9 14.6 1.1 1 0 0 1 1 1 0 Mitoguardin RskA PF10099.9 CDI81775.1 - 1.3 9.3 27.8 1.9 8.7 5.9 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA NST1 PF13945.6 CDI81775.1 - 1.4 9.0 14.2 2.1 8.4 14.2 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator Vfa1 PF08432.10 CDI81775.1 - 1.4 9.2 12.2 1.9 8.8 11.0 1.8 1 1 1 2 2 2 0 AAA-ATPase Vps4-associated protein 1 BAF1_ABF1 PF04684.13 CDI81775.1 - 1.8 7.5 14.4 2.1 7.3 14.4 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4554 PF15091.6 CDI81775.1 - 1.9 7.3 15.1 2.3 7.0 15.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) RAP1 PF07218.11 CDI81775.1 - 1.9 6.7 13.7 1.9 6.7 13.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PAT1 PF09770.9 CDI81775.1 - 2.4 6.3 15.3 3 6.0 15.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LAP1C PF05609.12 CDI81775.1 - 2.6 7.1 18.0 3.1 6.8 18.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Raftlin PF15250.6 CDI81775.1 - 3 6.5 11.9 3.6 6.2 11.9 1.1 1 0 0 1 1 1 0 Raftlin Peroxin-3 PF04882.12 CDI81775.1 - 3.5 6.5 16.3 4.7 6.1 16.3 1.4 1 0 0 1 1 1 0 Peroxin-3 Plasmodium_Vir PF05795.11 CDI81775.1 - 4.1 6.7 12.1 5.3 6.4 12.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Presenilin PF01080.17 CDI81775.1 - 4.1 6.1 17.2 5.1 5.8 17.2 1.2 1 0 0 1 1 1 0 Presenilin Peptidase_S64 PF08192.11 CDI81775.1 - 4.1 5.8 17.3 4.7 5.6 17.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF4551 PF15087.6 CDI81775.1 - 4.8 5.9 16.4 5.4 5.7 16.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SLC12 PF03522.15 CDI81775.1 - 5.4 5.9 10.4 6.5 5.7 10.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI81775.1 - 5.4 5.0 13.3 5.2 5.1 13.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SARAF PF06682.12 CDI81775.1 - 5.7 6.5 21.4 7.2 6.1 21.4 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis MPM1 PF17234.2 CDI81775.1 - 8 6.7 10.9 13 6.0 10.9 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 HSD3 PF15244.6 CDI81775.1 - 9.6 5.6 18.6 12 5.3 18.6 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 PHD_2 PF13831.6 CDI81776.1 - 0.28 10.8 7.4 0.75 9.4 7.4 1.8 1 0 0 1 1 1 0 PHD-finger U-box PF04564.15 CDI81781.1 - 2.4e-14 53.3 0.2 1.1e-13 51.1 0.0 2.1 2 0 0 2 2 2 1 U-box domain TPR_1 PF00515.28 CDI81781.1 - 4.1e-14 51.7 6.6 3.5e-05 23.4 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDI81781.1 - 2.9e-12 45.7 7.0 0.00045 20.1 1.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDI81781.1 - 8e-08 31.9 6.7 0.0088 16.2 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDI81781.1 - 1.7e-06 28.2 5.6 0.032 14.5 0.3 3.4 1 1 2 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI81781.1 - 5.2e-06 26.6 0.9 9.3e-06 25.8 0.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 CDI81781.1 - 1.1e-05 25.5 0.4 0.00022 21.3 0.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDI81781.1 - 2.1e-05 24.1 5.5 0.035 13.8 0.0 3.2 1 1 2 3 3 3 3 TPR repeat TPR_16 PF13432.6 CDI81781.1 - 2.6e-05 24.8 5.1 0.019 15.6 1.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat zf-NOSIP PF15906.5 CDI81781.1 - 0.0095 16.1 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein TPR_10 PF13374.6 CDI81781.1 - 0.011 15.6 4.0 1.4 8.9 0.3 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDI81781.1 - 0.019 15.8 3.6 1.5 9.8 0.0 3.6 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDI81781.1 - 0.023 15.2 3.9 0.077 13.5 2.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Bac_DNA_binding PF00216.21 CDI81781.1 - 0.031 14.5 0.0 0.065 13.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial DNA-binding protein SHNi-TPR PF10516.9 CDI81781.1 - 0.065 12.7 0.2 0.28 10.7 0.1 2.1 2 0 0 2 2 2 0 SHNi-TPR IL17 PF06083.11 CDI81781.1 - 0.069 13.6 0.3 0.37 11.3 0.1 2.0 2 0 0 2 2 2 0 Interleukin-17 DUF3435 PF11917.8 CDI81781.1 - 0.075 12.0 0.6 0.1 11.5 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) TPR_17 PF13431.6 CDI81781.1 - 0.099 13.1 0.2 3.8 8.1 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDI81781.1 - 0.11 12.6 6.3 27 5.1 0.1 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat Mod_r PF07200.13 CDI81781.1 - 0.14 12.2 1.8 0.54 10.4 0.1 2.1 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TPR_6 PF13174.6 CDI81781.1 - 1.1 10.0 4.1 45 5.0 0.1 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat ubiquitin PF00240.23 CDI81783.1 - 2.6e-34 116.8 0.3 3.6e-34 116.3 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 CDI81783.1 - 5.9e-30 102.9 11.2 9e-30 102.3 11.2 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 CDI81783.1 - 6.8e-17 61.1 0.5 1e-16 60.5 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CDI81783.1 - 3.3e-06 27.5 0.1 1.2e-05 25.7 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CDI81783.1 - 0.004 17.1 0.0 0.0053 16.7 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 CDI81783.1 - 0.011 16.1 0.0 0.016 15.5 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CDI81783.1 - 0.013 15.6 0.0 0.028 14.5 0.0 1.7 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 CDI81783.1 - 0.025 14.6 0.8 5.7 7.1 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 CDI81783.1 - 0.044 14.4 0.0 0.052 14.1 0.0 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain SNARE_assoc PF09335.11 CDI81784.1 - 2.7e-15 56.9 8.7 1.5e-14 54.5 6.4 2.4 2 0 0 2 2 2 1 SNARE associated Golgi protein DUF3087 PF11286.8 CDI81784.1 - 0.18 11.3 0.1 0.18 11.3 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) Abhydrolase_9_N PF15420.6 CDI81784.1 - 0.44 10.5 5.7 0.09 12.8 1.2 2.1 2 1 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus PARG_cat PF05028.14 CDI81786.1 - 5.4e-82 275.8 0.0 7.8e-82 275.3 0.0 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Crisp PF08562.10 CDI81786.1 - 0.071 13.7 0.7 0.12 12.9 0.7 1.3 1 0 0 1 1 1 0 Crisp FAD_binding_4 PF01565.23 CDI81789.1 - 4.3e-24 84.8 0.2 1.2e-23 83.3 0.2 1.7 1 1 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 CDI81789.1 - 8.4e-19 68.2 0.0 1.3e-18 67.6 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain Surface_antigen PF11054.8 CDI81791.1 - 3.2e-26 92.5 7.9 8.8e-26 91.1 7.9 1.6 1 1 0 1 1 1 1 Sporozoite TA4 surface antigen DUF3439 PF11921.8 CDI81791.1 - 0.22 11.5 8.6 0.6 10.1 8.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) zf-RING_2 PF13639.6 CDI81793.1 - 3.7e-09 36.8 12.4 7.1e-09 35.9 12.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CDI81793.1 - 3.2e-06 27.3 9.9 7.6e-06 26.1 9.9 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 CDI81793.1 - 5.5e-06 26.0 1.0 1.2e-05 25.0 1.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDI81793.1 - 2.7e-05 23.9 11.5 4.9e-05 23.1 11.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDI81793.1 - 0.00063 19.6 7.1 0.0013 18.6 7.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDI81793.1 - 0.0012 18.8 3.4 0.0028 17.6 3.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDI81793.1 - 0.0056 16.6 10.2 0.012 15.6 10.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CDI81793.1 - 0.0057 16.5 8.9 0.011 15.6 8.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CDI81793.1 - 0.078 12.6 10.2 0.16 11.7 10.2 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 CDI81793.1 - 0.25 11.4 7.4 0.26 11.4 5.7 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 CDI81793.1 - 0.35 11.0 8.6 0.68 10.1 8.6 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 Band_3_cyto PF07565.13 CDI81793.1 - 1.2 8.8 4.1 0.37 10.5 1.0 1.7 2 0 0 2 2 2 0 Band 3 cytoplasmic domain zf-RING_4 PF14570.6 CDI81793.1 - 1.8 8.4 5.5 3.7 7.4 5.5 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain EOS1 PF12326.8 CDI81793.1 - 2 8.3 3.8 4.9 7.0 0.8 2.3 2 0 0 2 2 2 0 N-glycosylation protein Suf PF05843.14 CDI81793.1 - 4.3 7.2 8.3 0.18 11.8 2.3 1.7 2 0 0 2 2 1 0 Suppressor of forked protein (Suf) DUF2722 PF10846.8 CDI81793.1 - 8.7 5.2 21.8 0.0082 15.1 8.4 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) TMEM100 PF16311.5 CDI81796.1 - 0.032 13.8 0.1 0.065 12.8 0.1 1.4 1 0 0 1 1 1 0 Transmembrane protein 100 DUF4064 PF13273.6 CDI81796.1 - 0.037 14.3 1.2 0.28 11.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) LapA_dom PF06305.11 CDI81796.1 - 0.041 13.7 0.1 0.089 12.6 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF2975 PF11188.8 CDI81796.1 - 0.11 12.4 0.4 0.91 9.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) MitoNEET_N PF10660.9 CDI81798.1 - 0.048 13.7 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus DUF202 PF02656.15 CDI81798.1 - 0.086 13.3 0.9 0.15 12.5 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF202) DUF4148 PF13663.6 CDI81798.1 - 0.11 12.7 1.6 8.4 6.7 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) SARAF PF06682.12 CDI81798.1 - 0.11 12.1 0.1 0.2 11.3 0.0 1.4 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis RAP1 PF07218.11 CDI81822.1 - 0.0027 16.1 2.9 0.003 16.0 2.9 1.1 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) TAP35_44 PF07265.11 CDI81825.1 - 0.11 12.5 1.2 0.13 12.3 1.2 1.1 1 0 0 1 1 1 0 Tapetum specific protein TAP35/TAP44 Hydin_ADK PF17213.3 CDI81825.1 - 5.2 7.3 15.1 6.1 7.1 15.1 1.0 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Adeno_PV PF03910.13 CDI81825.1 - 7.2 5.2 10.5 8.6 5.0 10.5 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV PRCC PF10253.9 CDI81826.1 - 0.34 11.7 26.9 0.37 11.5 26.9 1.0 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Hamartin PF04388.12 CDI81826.1 - 1.6 7.3 20.0 1.7 7.2 20.0 1.0 1 0 0 1 1 1 0 Hamartin protein IHABP4_N PF16174.5 CDI81826.1 - 2.5 8.7 22.3 3.4 8.2 22.3 1.3 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal FAM60A PF15396.6 CDI81826.1 - 2.6 8.0 13.9 3 7.8 13.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SID-1_RNA_chan PF13965.6 CDI81826.1 - 2.9 6.2 7.7 3 6.1 7.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SprA-related PF12118.8 CDI81826.1 - 3.9 6.5 36.4 4.1 6.4 36.4 1.0 1 0 0 1 1 1 0 SprA-related family PXA PF02194.15 CDI81826.1 - 4.8 7.1 10.7 5.5 6.9 10.7 1.1 1 0 0 1 1 1 0 PXA domain AAA_23 PF13476.6 CDI81826.1 - 5.2 7.5 14.0 6.3 7.2 14.0 1.1 1 0 0 1 1 1 0 AAA domain SOBP PF15279.6 CDI81826.1 - 6.8 7.2 22.2 7.1 7.1 22.2 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein OATP PF03137.20 CDI81826.1 - 7.5 4.7 7.1 8.8 4.5 7.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CDK5_activator PF03261.15 CDI81826.1 - 8.4 5.8 17.1 9.1 5.7 17.1 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Gti1_Pac2 PF09729.9 CDI81826.1 - 8.5 6.4 13.4 10 6.2 13.4 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family FliN_N PF16973.5 CDI81829.1 - 3.1 7.7 6.7 14 5.6 0.1 2.8 2 1 0 2 2 2 0 Flagellar motor switch protein FliN N-terminal Exonuc_VII_L PF02601.15 CDI81831.1 - 0.0013 18.3 19.7 0.0013 18.3 19.7 3.1 3 0 0 3 3 3 2 Exonuclease VII, large subunit Med15 PF09606.10 CDI81831.1 - 0.049 12.3 74.6 0.37 9.4 28.4 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal LodA_N PF17990.1 CDI81831.1 - 0.23 11.4 7.9 0.53 10.2 7.9 1.6 1 0 0 1 1 1 0 L-Lysine epsilon oxidase N-terminal TFIIA PF03153.13 CDI81831.1 - 3.4 7.6 88.2 1.7 8.5 32.2 2.5 1 1 1 3 3 3 0 Transcription factor IIA, alpha/beta subunit GET2 PF08690.10 CDI81831.1 - 4.9 6.7 29.2 1 9.0 15.1 3.3 3 0 0 3 3 3 0 GET complex subunit GET2 Pex14_N PF04695.13 CDI81839.1 - 0.0059 17.3 27.2 0.007 17.0 27.2 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region CobT PF06213.12 CDI81839.1 - 0.016 14.6 24.7 0.019 14.4 24.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RR_TM4-6 PF06459.12 CDI81839.1 - 0.017 15.0 18.9 0.018 14.9 18.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 EBP50_C PF09007.11 CDI81839.1 - 0.022 15.7 15.5 0.026 15.5 15.5 1.1 1 0 0 1 1 1 0 EBP50, C-terminal Gti1_Pac2 PF09729.9 CDI81839.1 - 0.025 14.7 15.1 0.03 14.4 15.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF913 PF06025.12 CDI81839.1 - 0.026 13.5 10.8 0.029 13.4 10.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 CDI81839.1 - 0.033 12.5 15.0 0.033 12.5 15.0 1.0 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 CDI81839.1 - 0.04 12.7 20.1 0.045 12.6 20.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TYW3 PF02676.14 CDI81839.1 - 0.04 13.3 9.9 0.046 13.1 9.9 1.0 1 0 0 1 1 1 0 Methyltransferase TYW3 DUF702 PF05142.12 CDI81839.1 - 0.052 14.0 17.8 0.07 13.6 17.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF702) CCSAP PF15748.5 CDI81839.1 - 0.071 13.3 20.8 0.079 13.1 20.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Presenilin PF01080.17 CDI81839.1 - 0.079 11.7 23.2 0.085 11.6 23.2 1.1 1 0 0 1 1 1 0 Presenilin DUF4698 PF15769.5 CDI81839.1 - 0.085 11.9 20.1 0.096 11.7 20.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) SpoIIP PF07454.11 CDI81839.1 - 0.098 12.1 19.9 0.12 11.8 19.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4366 PF14283.6 CDI81839.1 - 0.1 12.6 6.7 0.13 12.3 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF5427 PF10310.9 CDI81839.1 - 0.12 11.4 20.6 0.14 11.1 20.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF5308 PF17233.2 CDI81839.1 - 0.12 12.6 14.2 0.16 12.2 14.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Lin-8 PF03353.15 CDI81839.1 - 0.12 11.9 23.9 0.14 11.7 23.9 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Peptidase_U57 PF05582.12 CDI81839.1 - 0.17 11.1 12.0 0.19 11.0 12.0 1.2 1 0 0 1 1 1 0 YabG peptidase U57 SKA1 PF07160.12 CDI81839.1 - 0.18 11.7 23.0 0.19 11.5 23.0 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 PTPRCAP PF15713.5 CDI81839.1 - 0.2 11.9 20.0 0.25 11.6 20.0 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Endostatin PF06482.11 CDI81839.1 - 0.2 11.1 18.3 0.23 10.9 18.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF2828 PF11443.8 CDI81839.1 - 0.22 9.6 18.9 0.23 9.5 18.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4569 PF15133.6 CDI81839.1 - 0.22 11.2 24.0 0.27 10.9 24.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) ALMT PF11744.8 CDI81839.1 - 0.23 10.3 16.9 0.25 10.1 16.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter NARP1 PF12569.8 CDI81839.1 - 0.24 10.3 18.5 0.29 10.0 18.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 GvpL_GvpF PF06386.11 CDI81839.1 - 0.25 11.3 14.1 0.35 10.7 14.1 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF PAT1 PF09770.9 CDI81839.1 - 0.26 9.5 37.6 0.29 9.3 37.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Rtf2 PF04641.12 CDI81839.1 - 0.3 10.4 16.0 0.37 10.1 16.0 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger CCDC53 PF10152.9 CDI81839.1 - 0.31 11.5 21.3 0.38 11.2 21.3 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex FAM60A PF15396.6 CDI81839.1 - 0.34 10.9 15.8 0.39 10.7 15.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF2561 PF10812.8 CDI81839.1 - 0.34 10.9 1.4 0.4 10.7 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) PPL5 PF18168.1 CDI81839.1 - 0.39 10.0 13.7 0.43 9.8 13.7 1.1 1 0 0 1 1 1 0 Prim-pol family 5 BORG_CEP PF14957.6 CDI81839.1 - 0.41 11.8 14.0 0.5 11.5 14.0 1.2 1 0 0 1 1 1 0 Cdc42 effector Tim54 PF11711.8 CDI81839.1 - 0.44 9.3 17.6 0.5 9.1 17.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Hid1 PF12722.7 CDI81839.1 - 0.44 8.6 21.3 0.49 8.5 21.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HCO3_cotransp PF00955.21 CDI81839.1 - 0.47 9.2 8.9 0.54 9.0 8.9 1.0 1 0 0 1 1 1 0 HCO3- transporter family DUF935 PF06074.12 CDI81839.1 - 0.48 9.1 16.1 0.53 9.0 16.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF935) Asp-B-Hydro_N PF05279.11 CDI81839.1 - 0.55 10.3 12.9 0.59 10.2 12.9 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Peptidase_S64 PF08192.11 CDI81839.1 - 0.58 8.6 19.3 0.69 8.3 19.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF3984 PF13136.6 CDI81839.1 - 0.61 9.4 17.7 0.83 9.0 17.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) PIP5K PF01504.18 CDI81839.1 - 0.68 9.1 16.5 0.84 8.8 16.5 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase SLC12 PF03522.15 CDI81839.1 - 0.68 8.9 22.3 0.77 8.7 22.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Spore_coat_CotO PF14153.6 CDI81839.1 - 0.71 9.8 29.5 0.85 9.5 29.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Neur_chan_memb PF02932.16 CDI81839.1 - 0.79 9.7 18.8 0.89 9.6 18.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RP-C_C PF11800.8 CDI81839.1 - 0.93 9.5 17.5 1.1 9.3 17.5 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region DDRGK PF09756.9 CDI81839.1 - 1.1 8.9 28.8 1.4 8.5 28.8 1.1 1 0 0 1 1 1 0 DDRGK domain eIF-3_zeta PF05091.12 CDI81839.1 - 1.1 8.2 25.4 1.4 7.8 25.4 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4746 PF15928.5 CDI81839.1 - 1.2 8.5 15.0 1.4 8.2 15.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CLN3 PF02487.17 CDI81839.1 - 1.3 8.0 17.1 1.5 7.8 17.1 1.1 1 0 0 1 1 1 0 CLN3 protein DUF2072 PF09845.9 CDI81839.1 - 1.3 9.3 13.2 1.6 8.9 13.2 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein TCP PF03634.13 CDI81839.1 - 1.5 9.3 21.2 2.1 8.9 21.2 1.2 1 0 0 1 1 1 0 TCP family transcription factor Band_3_cyto PF07565.13 CDI81839.1 - 1.6 8.5 19.8 2.2 8.0 19.8 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Cellulose_synt PF03552.14 CDI81839.1 - 1.6 7.1 7.1 1.6 7.1 7.1 1.0 1 0 0 1 1 1 0 Cellulose synthase Membralin PF09746.9 CDI81839.1 - 1.7 7.6 15.6 1.9 7.4 15.6 1.0 1 0 0 1 1 1 0 Tumour-associated protein Paramyxo_ncap PF00973.19 CDI81839.1 - 1.8 7.4 18.2 2.1 7.2 18.2 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein AUX_IAA PF02309.16 CDI81839.1 - 1.9 8.3 14.0 2.2 8.1 14.0 1.1 1 0 0 1 1 1 0 AUX/IAA family Serinc PF03348.15 CDI81839.1 - 2 7.3 13.4 2.3 7.0 13.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Scs3p PF10261.9 CDI81839.1 - 2 7.8 6.1 2.6 7.5 6.1 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM MMU163 PF17119.5 CDI81839.1 - 2.1 7.4 9.5 3 7.0 9.5 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Ndc1_Nup PF09531.10 CDI81839.1 - 2.5 6.7 17.0 3.2 6.3 17.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup VIR_N PF15912.5 CDI81839.1 - 2.6 7.6 14.1 3.3 7.2 14.1 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal GREB1 PF15782.5 CDI81839.1 - 2.7 5.0 22.5 3.1 4.8 22.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Otopetrin PF03189.13 CDI81839.1 - 2.7 6.7 14.1 3.3 6.4 14.1 1.2 1 0 0 1 1 1 0 Otopetrin Zip PF02535.22 CDI81839.1 - 2.7 7.1 15.5 3.1 6.9 15.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RPN2_C PF18004.1 CDI81839.1 - 2.8 7.8 20.2 3.6 7.5 20.2 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain ASC PF00858.24 CDI81839.1 - 2.8 6.8 14.2 3.3 6.6 14.2 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Kei1 PF08552.11 CDI81839.1 - 2.9 7.7 15.5 3.7 7.4 15.5 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Connexin PF00029.19 CDI81839.1 - 3.1 7.5 20.4 4.1 7.1 20.4 1.1 1 0 0 1 1 1 0 Connexin HI0933_like PF03486.14 CDI81839.1 - 4.7 5.8 13.7 5.1 5.7 13.7 1.0 1 0 0 1 1 1 0 HI0933-like protein DUF4050 PF13259.6 CDI81839.1 - 4.8 7.5 19.3 5.8 7.2 19.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Afi1 PF07792.12 CDI81839.1 - 5.2 7.6 22.4 7 7.1 22.4 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking SelP_N PF04592.14 CDI81839.1 - 5.2 6.4 29.8 7 6.0 29.8 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region O-antigen_lig PF13425.6 CDI81839.1 - 5.3 5.7 14.8 5.9 5.6 14.8 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Sec62 PF03839.16 CDI81839.1 - 5.6 6.4 18.6 6.9 6.1 18.6 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 NST1 PF13945.6 CDI81839.1 - 6.6 6.8 30.9 9.2 6.3 30.9 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Calici_coat_C PF08435.11 CDI81839.1 - 7.6 6.0 15.0 9.3 5.7 15.0 1.1 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal MDM10 PF12519.8 CDI81839.1 - 7.7 5.3 21.8 9.1 5.0 21.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 V_ATPase_I PF01496.19 CDI81839.1 - 9.3 4.0 26.2 11 3.7 26.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MDM31_MDM32 PF08118.11 CDI81839.1 - 9.6 4.7 14.7 15 4.1 14.7 1.3 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF615 PF04751.14 CDI81845.1 - 0.08 12.9 0.5 0.11 12.5 0.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF615) PH_4 PF15404.6 CDI81851.1 - 0.68 9.7 0.0 0.68 9.7 0.0 3.4 3 0 0 3 3 3 0 Pleckstrin homology domain DUF1980 PF09323.10 CDI81851.1 - 2.6 7.9 16.7 6.9 6.5 3.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Kei1 PF08552.11 CDI81861.1 - 0.56 10.1 5.1 0.67 9.8 5.1 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 TraG_N PF07916.11 CDI81861.1 - 0.57 9.0 8.4 0.69 8.7 8.4 1.0 1 0 0 1 1 1 0 TraG-like protein, N-terminal region DUF1180 PF06679.12 CDI81861.1 - 0.96 9.8 8.1 1.1 9.6 8.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Presenilin PF01080.17 CDI81861.1 - 1.3 7.7 4.7 1.4 7.6 4.7 1.1 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 CDI81861.1 - 2.7 6.5 11.8 3 6.3 11.8 1.0 1 0 0 1 1 1 0 Macoilin family GHMP_kinases_N PF00288.26 CDI81861.1 - 2.8 8.3 13.4 3.1 8.1 0.6 2.3 2 0 0 2 2 2 0 GHMP kinases N terminal domain Apt1 PF10351.9 CDI81861.1 - 3.8 6.2 9.0 4.2 6.1 9.0 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Spc7_N PF15402.6 CDI81861.1 - 5.7 5.0 16.5 6.3 4.9 16.5 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 PE_PPE_C PF12484.8 CDI81868.1 - 4.8 8.2 28.5 3.9 8.5 1.8 3.4 3 0 0 3 3 3 0 Polymorphic PE/PPE proteins C terminal Shadoo PF14999.6 CDI81868.1 - 9.2 6.4 31.5 2.2 8.4 3.3 3.2 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective DUF4207 PF13904.6 CDI81872.1 - 0.0046 16.7 8.5 0.0046 16.7 8.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4207) DUF4611 PF15387.6 CDI81872.1 - 0.011 15.9 11.3 0.011 15.9 11.3 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4611) RskA PF10099.9 CDI81872.1 - 0.067 13.5 36.6 2.2 8.5 14.8 3.0 1 1 2 3 3 3 0 Anti-sigma-K factor rskA Chorion_2 PF03964.15 CDI81872.1 - 0.52 11.2 13.8 1 10.2 5.2 2.5 2 0 0 2 2 2 0 Chorion family 2 RRM_1 PF00076.22 CDI81873.1 - 8.1e-06 25.6 0.2 8.6e-05 22.3 0.0 2.6 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 CDI81873.1 - 0.012 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 RL domain RRM_7 PF16367.5 CDI81873.1 - 0.026 14.7 0.0 0.19 11.8 0.0 2.1 1 1 0 1 1 1 0 RNA recognition motif TMEM247 PF15444.6 CDI81873.1 - 0.51 10.3 7.5 0.63 10.0 7.5 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 DUF966 PF06136.13 CDI81873.1 - 0.76 9.4 6.0 0.75 9.4 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) GREB1 PF15782.5 CDI81873.1 - 2.9 4.9 6.1 3 4.8 6.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 CDI81874.1 - 0.0034 16.2 23.1 0.004 16.0 23.1 1.1 1 0 0 1 1 1 1 Presenilin CDC45 PF02724.14 CDI81874.1 - 0.028 12.7 18.9 0.033 12.5 18.9 1.0 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI81874.1 - 0.091 11.8 26.5 0.095 11.7 26.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 HAUS6_N PF14661.6 CDI81874.1 - 0.12 12.0 29.8 0.15 11.6 29.8 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF4045 PF13254.6 CDI81874.1 - 0.25 10.9 18.1 0.3 10.7 18.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PAT1 PF09770.9 CDI81874.1 - 0.67 8.2 45.9 0.74 8.0 45.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Zip PF02535.22 CDI81874.1 - 0.72 9.0 8.7 1.1 8.4 8.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter ASC PF00858.24 CDI81874.1 - 0.75 8.7 11.0 1 8.2 11.0 1.3 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel FAM60A PF15396.6 CDI81874.1 - 0.81 9.6 19.3 1.2 9.1 19.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A AAA_24 PF13479.6 CDI81874.1 - 1 9.0 11.5 1.4 8.6 11.5 1.2 1 0 0 1 1 1 0 AAA domain LAP1C PF05609.12 CDI81874.1 - 1.5 7.9 29.6 1.7 7.6 29.6 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) HCO3_cotransp PF00955.21 CDI81874.1 - 1.7 7.4 9.8 2 7.1 9.8 1.2 1 0 0 1 1 1 0 HCO3- transporter family MoeA_N PF03453.17 CDI81874.1 - 1.9 8.2 5.9 11 5.7 5.8 2.0 1 1 0 1 1 1 0 MoeA N-terminal region (domain I and II) Hid1 PF12722.7 CDI81874.1 - 2.5 6.1 28.4 3.1 5.8 28.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AbLIM_anchor PF16182.5 CDI81874.1 - 3 7.6 18.4 3.6 7.3 18.4 1.1 1 0 0 1 1 1 0 Putative adherens-junction anchoring region of AbLIM Hydin_ADK PF17213.3 CDI81874.1 - 3.3 7.9 21.4 4.6 7.5 21.4 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Nop53 PF07767.11 CDI81874.1 - 4.4 6.6 37.9 5.4 6.3 37.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PA26 PF04636.13 CDI81874.1 - 4.7 6.0 23.5 5.7 5.8 23.5 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) V_ATPase_I PF01496.19 CDI81874.1 - 5.6 4.7 31.0 6.2 4.6 31.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ALMT PF11744.8 CDI81874.1 - 6.1 5.6 21.7 7.5 5.3 21.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CCSAP PF15748.5 CDI81874.1 - 9 6.4 28.9 12 6.0 28.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated XRN_M PF17846.1 CDI81874.1 - 9 5.1 23.0 10 4.9 23.0 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Trypan_PARP PF05887.11 CDI81875.1 - 8.3e-05 22.6 4.5 8.3e-05 22.6 4.5 2.5 2 1 1 3 3 3 1 Procyclic acidic repetitive protein (PARP) Vfa1 PF08432.10 CDI81875.1 - 0.0048 17.2 6.6 0.0048 17.2 6.6 5.1 4 1 1 5 5 5 2 AAA-ATPase Vps4-associated protein 1 SDA1 PF05285.12 CDI81875.1 - 0.46 9.9 77.3 0.019 14.4 28.2 3.2 3 0 0 3 3 3 0 SDA1 TFIIA PF03153.13 CDI81875.1 - 0.46 10.4 169.6 0.15 12.0 38.5 3.6 3 1 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit SseC PF04888.12 CDI81893.1 - 0.00044 20.0 23.5 0.00044 20.0 23.5 3.1 1 1 1 3 3 1 1 Secretion system effector C (SseC) like family MAM33 PF02330.16 CDI81893.1 - 0.022 14.7 4.6 0.022 14.7 4.6 3.5 2 1 0 2 2 1 0 Mitochondrial glycoprotein NPR3 PF03666.13 CDI81893.1 - 0.078 11.8 44.2 0.12 11.1 27.7 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Utp14 PF04615.13 CDI81893.1 - 0.12 11.0 48.1 0.15 10.7 48.1 1.0 1 0 0 1 1 1 0 Utp14 protein PI3K_1B_p101 PF10486.9 CDI81893.1 - 0.85 7.3 32.9 1.1 6.9 32.9 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit LMBR1 PF04791.16 CDI81893.1 - 1.1 8.1 24.3 1.8 7.3 24.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein MAP7 PF05672.11 CDI81893.1 - 1.7 8.3 74.5 3.5 7.3 45.4 2.2 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Band_3_cyto PF07565.13 CDI81893.1 - 1.9 8.2 51.7 1.1 9.0 9.9 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain FAM60A PF15396.6 CDI81893.1 - 3.1 7.7 44.0 2.9 7.9 27.0 2.2 2 0 0 2 2 2 0 Protein Family FAM60A PNISR PF15996.5 CDI81893.1 - 4.7 7.4 60.4 0.24 11.7 8.5 2.3 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR HCO3_cotransp PF00955.21 CDI81893.1 - 9.4 4.9 24.4 2.2 7.0 12.6 2.2 2 0 0 2 2 2 0 HCO3- transporter family SR-25 PF10500.9 CDI81894.1 - 3.4e-05 23.6 33.3 6.9e-05 22.6 12.4 6.4 5 1 0 5 5 5 2 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 CDI81894.1 - 0.00048 20.4 31.8 0.00048 20.4 31.8 9.8 7 3 2 9 9 9 2 Domain of unknown function (DUF755) Pox_A12 PF04651.13 CDI81894.1 - 0.59 10.2 34.4 0.058 13.5 1.0 3.7 3 0 0 3 3 3 0 Poxvirus A12 protein Ribosomal_60s PF00428.19 CDI81898.1 - 0.0091 16.6 5.0 0.0091 16.6 5.0 2.2 2 0 0 2 2 2 2 60s Acidic ribosomal protein Ank_2 PF12796.7 CDI81923.1 - 3.7e-05 24.2 8.6 0.023 15.3 0.0 3.7 3 0 0 3 3 2 2 Ankyrin repeats (3 copies) AF-4 PF05110.13 CDI81923.1 - 8.4e-05 20.9 28.7 8.4e-05 20.9 28.7 15.6 9 5 2 14 14 7 1 AF-4 proto-oncoprotein SPX PF03105.19 CDI81923.1 - 0.00056 19.9 12.4 0.00056 19.9 12.4 12.8 4 2 2 6 6 2 1 SPX domain RskA PF10099.9 CDI81923.1 - 0.0027 18.0 9.3 0.0027 18.0 9.3 28.1 4 3 17 23 23 12 3 Anti-sigma-K factor rskA LRR_8 PF13855.6 CDI81923.1 - 0.0033 17.1 12.3 0.0039 16.9 9.0 2.5 2 1 0 2 2 2 1 Leucine rich repeat NAM-associated PF14303.6 CDI81923.1 - 0.0084 16.8 1.8 0.0084 16.8 1.8 18.1 15 5 0 16 16 10 1 No apical meristem-associated C-terminal domain Ank_4 PF13637.6 CDI81923.1 - 0.023 15.3 1.3 0.12 13.0 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.30 CDI81923.1 - 0.089 13.3 0.0 8.6 7.0 0.1 3.7 2 0 0 2 2 2 0 Ankyrin repeat Mif2_N PF15624.6 CDI81923.1 - 0.21 12.3 0.1 0.21 12.3 0.1 15.4 10 4 6 17 17 4 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Ank_3 PF13606.6 CDI81923.1 - 0.69 10.7 4.6 22 6.1 0.0 5.1 6 0 0 6 6 5 0 Ankyrin repeat LRR_4 PF12799.7 CDI81923.1 - 4.6 7.8 10.6 21 5.7 8.7 2.9 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) Spt20 PF12090.8 CDI81946.1 - 0.00022 20.9 5.1 0.00022 20.9 5.1 3.4 3 0 0 3 3 3 3 Spt20 family Activator_LAG-3 PF11498.8 CDI81946.1 - 0.043 12.8 44.4 0.11 11.5 14.7 3.5 3 0 0 3 3 3 0 Transcriptional activator LAG-3 Rxt3 PF08642.10 CDI81946.1 - 2.7 8.8 0.0 2.7 8.8 0.0 3.8 3 2 1 4 4 4 0 Histone deacetylation protein Rxt3 SLC12 PF03522.15 CDI81946.1 - 3.7 6.5 12.8 0.33 9.9 6.4 1.9 2 0 0 2 2 2 0 Solute carrier family 12 Presenilin PF01080.17 CDI81948.1 - 0.018 13.9 36.0 0.024 13.4 36.0 1.3 1 0 0 1 1 1 0 Presenilin DUF2126 PF09899.9 CDI81948.1 - 0.02 13.0 15.8 0.021 13.0 15.8 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CCSAP PF15748.5 CDI81948.1 - 0.15 12.2 39.3 0.19 11.9 39.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4746 PF15928.5 CDI81948.1 - 0.19 11.1 17.3 0.22 10.9 17.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Endostatin PF06482.11 CDI81948.1 - 0.39 10.1 28.2 0.52 9.7 28.2 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin PAT1 PF09770.9 CDI81948.1 - 0.48 8.6 46.4 0.55 8.4 46.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3292 PF11696.8 CDI81948.1 - 0.55 8.5 15.9 0.57 8.5 15.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) SR-25 PF10500.9 CDI81948.1 - 0.64 9.6 37.2 1.1 8.9 37.2 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein LAP1C PF05609.12 CDI81948.1 - 0.71 8.9 39.3 0.74 8.8 39.3 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) LptF_LptG PF03739.14 CDI81948.1 - 1 8.2 8.5 1.1 8.1 8.5 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG PvlArgDC PF01862.16 CDI81948.1 - 1.1 9.0 5.1 1.6 8.5 5.1 1.2 1 0 0 1 1 1 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) HemX PF04375.14 CDI81948.1 - 1.2 8.4 49.0 1.2 8.3 49.0 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Peptidase_S15 PF02129.18 CDI81948.1 - 1.6 8.3 17.3 1.8 8.1 17.3 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Raftlin PF15250.6 CDI81948.1 - 1.8 7.2 30.6 2.2 6.9 30.6 1.0 1 0 0 1 1 1 0 Raftlin SOBP PF15279.6 CDI81948.1 - 2.1 8.9 33.4 2.4 8.7 33.4 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4045 PF13254.6 CDI81948.1 - 2.1 7.9 35.1 2.5 7.7 35.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) 5_nucleotid PF05761.14 CDI81948.1 - 3.8 6.3 18.1 3.8 6.3 18.1 1.2 1 0 0 1 1 1 0 5' nucleotidase family PNISR PF15996.5 CDI81948.1 - 4 7.7 38.5 5.9 7.1 38.5 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF853 PF05872.12 CDI81948.1 - 4.1 5.9 18.9 5.1 5.6 18.9 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) CDC45 PF02724.14 CDI81948.1 - 4.3 5.5 30.6 6.2 5.0 30.6 1.3 1 0 0 1 1 1 0 CDC45-like protein eIF-3_zeta PF05091.12 CDI81948.1 - 5 6.0 40.6 8.2 5.3 40.6 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Vac7 PF12751.7 CDI81948.1 - 5.1 6.4 25.0 6.9 6.0 25.0 1.2 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 BT1 PF03092.16 CDI81948.1 - 5.5 5.1 7.7 7.2 4.7 7.7 1.2 1 0 0 1 1 1 0 BT1 family TCP PF03634.13 CDI81948.1 - 5.6 7.5 38.6 9.2 6.8 38.6 1.4 1 0 0 1 1 1 0 TCP family transcription factor FemAB PF02388.16 CDI81948.1 - 6.8 5.4 26.4 8.6 5.1 26.4 1.1 1 0 0 1 1 1 0 FemAB family Kei1 PF08552.11 CDI81948.1 - 7.2 6.4 27.4 0.26 11.2 19.8 1.9 1 1 1 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Asp-B-Hydro_N PF05279.11 CDI81948.1 - 7.3 6.6 20.7 8.4 6.4 20.7 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Nha1_C PF08619.10 CDI81948.1 - 8.9 5.4 44.6 11 5.0 44.6 1.0 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus PA26 PF04636.13 CDI81948.1 - 9.7 5.0 24.6 15 4.4 24.6 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Stevor PF17410.2 CDI81952.1 - 4.7 6.7 15.4 6.7 6.2 15.4 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Connexin PF00029.19 CDI81955.1 - 0.022 14.5 12.4 0.023 14.5 12.4 1.0 1 0 0 1 1 1 0 Connexin DUF3408 PF11888.8 CDI81955.1 - 0.026 14.6 16.3 0.027 14.6 16.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Nop53 PF07767.11 CDI81955.1 - 0.037 13.4 27.6 0.04 13.3 27.6 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PTPRCAP PF15713.5 CDI81955.1 - 0.071 13.4 16.7 0.079 13.2 16.7 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated TIMELESS_C PF05029.13 CDI81955.1 - 0.083 12.0 18.0 0.089 11.9 18.0 1.0 1 0 0 1 1 1 0 Timeless protein C terminal region DUF2052 PF09747.9 CDI81955.1 - 0.086 13.0 20.5 0.094 12.8 20.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Coilin_N PF15862.5 CDI81955.1 - 0.094 12.5 15.0 0.1 12.4 15.0 1.2 1 0 0 1 1 1 0 Coilin N-terminus Conotoxin PF02950.17 CDI81955.1 - 0.11 13.5 7.4 1.8 9.6 7.4 2.0 1 1 0 1 1 1 0 Conotoxin CLN3 PF02487.17 CDI81955.1 - 0.12 11.4 5.4 0.12 11.4 5.4 1.0 1 0 0 1 1 1 0 CLN3 protein YqfQ PF14181.6 CDI81955.1 - 0.14 12.3 18.1 0.15 12.2 18.1 1.0 1 0 0 1 1 1 0 YqfQ-like protein Presenilin PF01080.17 CDI81955.1 - 0.16 10.7 8.3 0.17 10.6 8.3 1.0 1 0 0 1 1 1 0 Presenilin CENP-B_dimeris PF09026.10 CDI81955.1 - 0.16 12.3 9.2 0.18 12.2 9.2 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain OATP PF03137.20 CDI81955.1 - 0.2 9.9 4.9 0.2 9.9 4.9 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family TMEM214 PF10151.9 CDI81955.1 - 0.25 9.8 16.6 0.26 9.7 16.6 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator CobT PF06213.12 CDI81955.1 - 0.33 10.3 15.4 0.33 10.3 15.4 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 CDI81955.1 - 0.37 9.0 19.7 0.39 8.9 19.7 1.0 1 0 0 1 1 1 0 CDC45-like protein CPSF100_C PF13299.6 CDI81955.1 - 0.38 10.9 13.6 0.4 10.8 13.6 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal TipE PF16972.5 CDI81955.1 - 0.47 9.6 3.2 0.47 9.6 3.2 1.0 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE YL1 PF05764.13 CDI81955.1 - 0.49 10.5 28.5 0.55 10.3 28.5 1.0 1 0 0 1 1 1 0 YL1 nuclear protein TRAP_alpha PF03896.16 CDI81955.1 - 0.5 9.5 9.9 0.52 9.5 9.9 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FAM163 PF15069.6 CDI81955.1 - 0.51 10.8 4.1 0.6 10.5 4.1 1.2 1 0 0 1 1 1 0 FAM163 family Drc1-Sld2 PF11719.8 CDI81955.1 - 0.54 9.7 22.5 0.59 9.6 22.5 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein ORC_WH_C PF18137.1 CDI81955.1 - 0.6 10.2 11.6 0.87 9.6 11.6 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal G0-G1_switch_2 PF15103.6 CDI81955.1 - 0.6 10.6 9.7 0.72 10.3 9.7 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 GEN1_C PF18380.1 CDI81955.1 - 0.67 10.9 16.1 0.8 10.6 16.1 1.1 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain U3_snoRNA_assoc PF08297.11 CDI81955.1 - 0.69 10.7 21.2 0.96 10.2 21.2 1.3 1 0 0 1 1 1 0 U3 snoRNA associated eIF3_subunit PF08597.10 CDI81955.1 - 0.81 9.6 31.2 0.89 9.4 31.2 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit TLP-20 PF06088.11 CDI81955.1 - 0.99 9.3 12.5 1.2 9.0 12.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) GAGA_bind PF06217.12 CDI81955.1 - 1.1 9.5 14.8 1.1 9.4 14.8 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family V_ATPase_I PF01496.19 CDI81955.1 - 1.3 6.9 10.6 1.3 6.9 10.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nucleoside_tran PF01733.18 CDI81955.1 - 1.3 8.4 7.2 1.4 8.2 7.2 1.0 1 0 0 1 1 1 0 Nucleoside transporter DUF3381 PF11861.8 CDI81955.1 - 1.3 8.8 30.5 1.5 8.6 30.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) PGA2 PF07543.12 CDI81955.1 - 1.5 8.8 18.9 1.8 8.6 18.9 1.1 1 0 0 1 1 1 0 Protein trafficking PGA2 PcfK PF14058.6 CDI81955.1 - 1.5 9.1 21.8 1.7 8.9 21.8 1.1 1 0 0 1 1 1 0 PcfK-like protein Serinc PF03348.15 CDI81955.1 - 1.6 7.5 4.3 1.6 7.5 4.3 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) SURF2 PF05477.11 CDI81955.1 - 1.8 8.2 19.7 1.9 8.1 19.7 1.0 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Peptidase_S49_N PF08496.10 CDI81955.1 - 2 8.4 14.4 2.5 8.1 14.4 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal AIF_C PF14721.6 CDI81955.1 - 2.1 8.7 9.7 2.2 8.7 9.7 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term HSP90 PF00183.18 CDI81955.1 - 2.1 7.1 23.7 2.2 7.1 23.7 1.0 1 0 0 1 1 1 0 Hsp90 protein RRN3 PF05327.11 CDI81955.1 - 2.2 6.8 10.9 2.1 6.8 10.9 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Usp PF00582.26 CDI81955.1 - 2.3 8.7 6.3 2.9 8.4 6.3 1.2 1 0 0 1 1 1 0 Universal stress protein family XAP5 PF04921.14 CDI81955.1 - 2.3 8.0 19.0 2.7 7.8 19.0 1.0 1 0 0 1 1 1 0 XAP5, circadian clock regulator EOS1 PF12326.8 CDI81955.1 - 2.3 8.1 4.5 2.4 8.1 4.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein SpoIIP PF07454.11 CDI81955.1 - 2.8 7.3 16.8 2.9 7.3 16.8 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) EIIBC-GUT_N PF03612.14 CDI81955.1 - 3.1 7.5 11.4 3.5 7.3 11.4 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3807 PF12720.7 CDI81955.1 - 3.4 7.9 20.5 3.8 7.7 20.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Nop14 PF04147.12 CDI81955.1 - 3.7 5.6 25.2 4.1 5.5 25.2 1.0 1 0 0 1 1 1 0 Nop14-like family Peroxin-13_N PF04088.13 CDI81955.1 - 4.1 7.7 6.2 4.3 7.6 6.2 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region RPN2_C PF18004.1 CDI81955.1 - 4.6 7.1 24.3 5.5 6.9 24.3 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Paf1 PF03985.13 CDI81955.1 - 5.4 5.9 27.3 6 5.7 27.3 1.0 1 0 0 1 1 1 0 Paf1 DUF2828 PF11443.8 CDI81955.1 - 6.3 4.8 12.9 6.5 4.7 12.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Folate_carrier PF01770.18 CDI81955.1 - 6.3 5.4 6.9 6.2 5.4 6.9 1.1 1 0 0 1 1 1 0 Reduced folate carrier Fmp27 PF10344.9 CDI81955.1 - 7.1 4.6 16.5 7.3 4.5 16.5 1.0 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 Merozoite_SPAM PF07133.11 CDI81955.1 - 7.4 6.5 37.4 8.7 6.3 37.4 1.0 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) TFB6 PF17110.5 CDI81955.1 - 8 6.2 11.2 8.9 6.0 11.2 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH SID-1_RNA_chan PF13965.6 CDI81955.1 - 9.3 4.5 5.1 9.1 4.6 5.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ABC2_membrane_4 PF12730.7 CDI81963.1 - 0.14 12.1 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein MPM1 PF17234.2 CDI81963.1 - 0.18 12.0 11.5 0.25 11.6 1.4 3.2 3 0 0 3 3 3 0 Mitochondrial peculiar membrane protein 1 TFIIA PF03153.13 CDI81963.1 - 7.7 6.4 55.8 6.3 6.7 32.1 2.5 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit Utp14 PF04615.13 CDI81964.1 - 4.1 5.9 5.2 4.5 5.7 5.2 1.1 1 0 0 1 1 1 0 Utp14 protein RskA PF10099.9 CDI81968.1 - 2.4e-06 28.0 56.6 8.8e-06 26.1 0.1 3.7 2 1 2 4 4 4 3 Anti-sigma-K factor rskA Utp14 PF04615.13 CDI81968.1 - 4.2 5.8 41.9 2 6.9 18.2 2.2 2 0 0 2 2 2 0 Utp14 protein Rpp20 PF12328.8 CDI81972.1 - 9.3e-07 28.9 0.9 0.25 11.3 0.0 3.1 2 1 1 3 3 3 3 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 CDI81972.1 - 1.1e-06 28.3 0.0 2.1e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Alba Med13_C PF06333.12 CDI81973.1 - 2.2 7.5 9.0 0.11 11.8 2.7 1.9 2 0 0 2 2 2 0 Mediator complex subunit 13 C-terminal domain He_PIG PF05345.12 CDI81974.1 - 0.0019 18.3 0.0 0.0046 17.1 0.0 1.6 1 0 0 1 1 1 1 Putative Ig domain Dus PF01207.17 CDI81975.1 - 6.3e-25 87.9 0.1 2e-14 53.4 0.0 2.4 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) CCB1 PF12046.8 CDI81977.1 - 0.0098 15.3 0.1 0.0098 15.3 0.1 2.0 2 0 0 2 2 2 1 Cofactor assembly of complex C subunit B Presenilin PF01080.17 CDI81977.1 - 0.048 12.4 20.6 0.051 12.3 20.6 1.0 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CDI81977.1 - 0.065 14.2 26.2 0.22 12.5 10.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 CDI81977.1 - 0.082 13.8 1.1 0.082 13.8 1.1 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain CSG2 PF16965.5 CDI81977.1 - 0.12 11.3 9.9 0.16 10.9 9.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2828 PF11443.8 CDI81977.1 - 0.15 10.1 14.2 0.16 10.0 14.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) U1snRNP70_N PF12220.8 CDI81977.1 - 0.16 12.6 21.2 0.12 13.0 9.4 2.1 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal OAD_gamma PF04277.13 CDI81977.1 - 0.17 12.5 1.4 1.2 9.8 0.1 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF2214 PF09980.9 CDI81977.1 - 0.2 11.5 0.1 0.2 11.5 0.1 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2214) Porph_ging PF09697.10 CDI81977.1 - 0.23 12.0 12.4 0.47 11.0 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) DUF3169 PF11368.8 CDI81977.1 - 0.39 10.2 5.7 0.79 9.2 4.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) SID-1_RNA_chan PF13965.6 CDI81977.1 - 0.51 8.7 7.7 0.61 8.4 7.7 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 AIF_C PF14721.6 CDI81977.1 - 0.61 10.4 16.2 0.37 11.1 5.8 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term ORC_WH_C PF18137.1 CDI81977.1 - 1.1 9.4 18.8 1.6 8.8 8.3 2.0 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal DUF1117 PF06547.12 CDI81977.1 - 1.4 9.5 4.6 1.6 9.3 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) SLC12 PF03522.15 CDI81977.1 - 1.5 7.7 18.2 2 7.3 18.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 FYDLN_acid PF09538.10 CDI81977.1 - 2.1 9.1 15.7 0.68 10.6 6.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Mak16 PF04874.14 CDI81977.1 - 2.9 8.5 19.6 9.7 6.9 0.9 2.1 2 0 0 2 2 2 0 Mak16 protein C-terminal region AUX_IAA PF02309.16 CDI81977.1 - 3.9 7.3 11.9 5.6 6.8 11.9 1.2 1 0 0 1 1 1 0 AUX/IAA family XRN_M PF17846.1 CDI81977.1 - 4 6.3 14.2 4.7 6.1 14.2 1.1 1 0 0 1 1 1 0 Xrn1 helical domain DUF1764 PF08576.10 CDI81977.1 - 4.6 8.2 19.0 9.5 7.2 1.5 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) DUF3408 PF11888.8 CDI81977.1 - 5.1 7.2 22.4 6.3 6.9 2.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) DUF2140 PF09911.9 CDI81977.1 - 5.2 6.6 12.6 0.66 9.5 1.3 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) ATP-synt_E PF05680.12 CDI81977.1 - 5.4 7.4 21.0 1.2 9.5 8.9 2.1 2 0 0 2 2 2 0 ATP synthase E chain DUF2072 PF09845.9 CDI81977.1 - 6.1 7.1 15.4 3.9 7.7 7.3 2.1 2 0 0 2 2 2 0 Zn-ribbon containing protein G0-G1_switch_2 PF15103.6 CDI81977.1 - 6.9 7.2 18.4 4.1 7.9 7.9 2.1 2 0 0 2 2 2 0 G0/G1 switch protein 2 Hid1 PF12722.7 CDI81977.1 - 7.3 4.6 16.8 9.1 4.3 16.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PRC2_HTH_1 PF18118.1 CDI81977.1 - 8.2 7.3 16.7 13 6.6 1.0 2.1 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain UPF0239 PF06783.11 CDI81977.1 - 8.3 6.7 12.3 3.3 8.0 4.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) DUF2722 PF10846.8 CDI81977.1 - 8.9 5.1 50.9 0.16 10.8 14.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Spore_III_AF PF09581.10 CDI81977.1 - 9.2 6.2 22.3 1.3 9.0 10.6 2.0 2 0 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) MCM PF00493.23 CDI81990.1 - 7e-55 185.5 5.0 9.4e-31 106.6 1.2 2.5 1 1 1 2 2 2 2 MCM P-loop domain Mg_chelatase PF01078.21 CDI81990.1 - 3e-07 30.0 0.7 2.3e-05 23.9 0.1 2.6 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDI81990.1 - 3.5e-06 27.1 0.0 0.00089 19.3 0.0 2.4 1 1 1 2 2 2 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CDI81990.1 - 0.00016 21.5 0.1 0.047 13.4 0.0 2.2 1 1 1 2 2 2 2 Sigma-54 interaction domain AAA_3 PF07726.11 CDI81990.1 - 0.0032 17.3 0.1 0.043 13.7 0.1 2.3 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) SUIM_assoc PF16619.5 CDI81990.1 - 0.0047 17.0 15.6 0.039 14.0 2.6 2.4 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 cobW PF02492.19 CDI81990.1 - 0.046 13.3 0.2 0.097 12.2 0.2 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 CDI81990.1 - 0.046 14.1 2.7 0.048 14.0 0.2 2.1 2 1 0 2 2 2 0 AAA ATPase domain RskA PF10099.9 CDI81990.1 - 0.048 13.9 0.5 0.048 13.9 0.5 3.1 3 0 0 3 3 3 0 Anti-sigma-K factor rskA Folliculin PF11704.8 CDI81990.1 - 0.1 12.5 1.3 0.37 10.7 0.3 2.0 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport AAA_2 PF07724.14 CDI81990.1 - 0.18 11.9 4.0 0.98 9.5 0.0 2.8 2 1 1 3 3 3 0 AAA domain (Cdc48 subfamily) DUF966 PF06136.13 CDI81990.1 - 0.19 11.4 1.3 0.24 11.1 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) RskA PF10099.9 CDI81996.1 - 0.003 17.9 68.4 0.22 11.8 20.9 5.3 3 1 1 4 4 4 2 Anti-sigma-K factor rskA RNA_pol_3_Rpc31 PF11705.8 CDI81996.1 - 0.013 15.8 20.8 0.013 15.8 20.8 3.0 4 1 0 4 4 4 0 DNA-directed RNA polymerase III subunit Rpc31 TRAP_alpha PF03896.16 CDI81996.1 - 0.44 9.7 16.3 1.5 8.0 16.3 1.8 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit K_trans PF02705.16 CDI82000.1 - 0.18 10.3 7.2 0.26 9.8 7.2 1.2 1 0 0 1 1 1 0 K+ potassium transporter CD20 PF04103.15 CDI82000.1 - 2.4 8.2 5.8 0.29 11.2 0.4 2.1 1 1 1 2 2 2 0 CD20-like family DUF726 PF05277.12 CDI82000.1 - 3.7 6.4 9.6 5 5.9 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) VIT1 PF01988.19 CDI82001.1 - 8.5e-06 25.8 1.4 1.2e-05 25.3 1.4 1.3 1 0 0 1 1 1 1 VIT family DUF2417 PF10329.9 CDI82001.1 - 0.00024 20.6 0.2 0.0003 20.3 0.2 1.1 1 0 0 1 1 1 1 Region of unknown function (DUF2417) THOC2_N PF16134.5 CDI82001.1 - 0.0029 16.3 6.3 0.004 15.8 6.3 1.2 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus DUF1764 PF08576.10 CDI82001.1 - 0.0052 17.7 5.0 0.0052 17.7 5.0 1.9 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF1764) DUF2721 PF11026.8 CDI82001.1 - 0.0089 15.9 7.0 0.015 15.2 7.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2721) CbtA PF09490.10 CDI82001.1 - 0.011 15.5 3.4 0.013 15.3 3.4 1.2 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) ATG22 PF11700.8 CDI82001.1 - 0.012 14.3 4.1 0.014 14.0 4.1 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like DUF2561 PF10812.8 CDI82001.1 - 0.034 14.2 2.3 0.046 13.8 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) DUF2207 PF09972.9 CDI82001.1 - 0.042 12.6 0.3 0.048 12.4 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) LMBR1 PF04791.16 CDI82001.1 - 0.045 12.7 6.4 0.051 12.5 6.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Spt20 PF12090.8 CDI82001.1 - 0.047 13.3 49.4 0.1 12.2 39.5 2.1 2 0 0 2 2 2 0 Spt20 family Apc15p PF05841.11 CDI82001.1 - 0.047 14.5 19.0 0.062 14.1 19.0 1.1 1 0 0 1 1 1 0 Apc15p protein Orf78 PF06024.12 CDI82001.1 - 0.081 13.2 13.7 0.25 11.6 13.6 1.9 1 1 0 1 1 1 0 Orf78 (ac78) CSG2 PF16965.5 CDI82001.1 - 0.1 11.6 8.8 0.12 11.4 8.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator CDK2AP PF09806.9 CDI82001.1 - 0.11 12.6 18.9 0.15 12.1 18.9 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DIE2_ALG10 PF04922.12 CDI82001.1 - 0.12 11.7 7.2 0.082 12.2 6.1 1.3 1 1 0 1 1 1 0 DIE2/ALG10 family Connexin PF00029.19 CDI82001.1 - 0.12 12.1 12.3 0.03 14.1 9.3 1.5 1 1 1 2 2 2 0 Connexin CD20 PF04103.15 CDI82001.1 - 0.18 11.9 3.9 0.15 12.1 2.9 1.5 1 1 1 2 2 2 0 CD20-like family DUF2370 PF10176.9 CDI82001.1 - 0.24 11.0 10.2 0.29 10.8 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DcuA_DcuB PF03605.14 CDI82001.1 - 0.27 10.1 5.8 0.32 9.9 5.8 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Trp_oprn_chp PF09534.10 CDI82001.1 - 0.36 10.6 9.2 0.61 9.9 9.2 1.5 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4366 PF14283.6 CDI82001.1 - 0.38 10.8 9.1 0.25 11.4 7.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) CCB2_CCB4 PF11152.8 CDI82001.1 - 0.4 10.0 9.1 0.47 9.7 9.1 1.0 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B, CCB2/CCB4 DUF2126 PF09899.9 CDI82001.1 - 0.53 8.3 9.7 0.53 8.3 9.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Nucleoside_tran PF01733.18 CDI82001.1 - 0.58 9.5 5.1 0.66 9.3 5.1 1.2 1 0 0 1 1 1 0 Nucleoside transporter SLC12 PF03522.15 CDI82001.1 - 0.68 8.9 16.5 0.73 8.8 16.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Claudin_2 PF13903.6 CDI82001.1 - 0.7 9.6 5.5 0.5 10.1 4.1 1.5 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction EIIBC-GUT_N PF03612.14 CDI82001.1 - 0.74 9.5 17.1 0.11 12.3 11.9 1.8 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus HCO3_cotransp PF00955.21 CDI82001.1 - 0.76 8.5 7.3 0.86 8.4 7.3 1.1 1 0 0 1 1 1 0 HCO3- transporter family OATP PF03137.20 CDI82001.1 - 0.78 7.9 13.5 1.6 7.0 13.5 1.5 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family BNR_3 PF13859.6 CDI82001.1 - 0.93 8.7 8.8 1.1 8.5 8.8 1.1 1 0 0 1 1 1 0 BNR repeat-like domain DUF1180 PF06679.12 CDI82001.1 - 0.96 9.8 6.5 0.6 10.5 5.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) MDM10 PF12519.8 CDI82001.1 - 1.2 8.0 11.6 1.3 7.8 11.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Plasmodium_Vir PF05795.11 CDI82001.1 - 1.3 8.4 5.8 1.4 8.3 5.8 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF3043 PF11241.8 CDI82001.1 - 1.4 8.9 14.8 1 9.4 13.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3043) AUX_IAA PF02309.16 CDI82001.1 - 1.6 8.5 10.2 2.1 8.1 10.2 1.2 1 0 0 1 1 1 0 AUX/IAA family Peptidase_M56 PF05569.11 CDI82001.1 - 1.7 7.8 9.1 1.9 7.6 9.1 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 TFB6 PF17110.5 CDI82001.1 - 2 8.1 9.4 0.43 10.3 6.3 1.5 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF4064 PF13273.6 CDI82001.1 - 2 8.7 12.3 1.3 9.4 9.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) Ndc1_Nup PF09531.10 CDI82001.1 - 2.1 6.9 20.6 2.4 6.7 20.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PSK PF06404.12 CDI82001.1 - 2.9 8.9 17.4 3.1 8.9 12.7 2.1 2 0 0 2 2 2 0 Phytosulfokine precursor protein (PSK) PRC2_HTH_1 PF18118.1 CDI82001.1 - 3 8.7 13.4 0.34 11.7 8.3 1.8 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Arv1 PF04161.13 CDI82001.1 - 3.3 7.8 7.1 4.4 7.4 7.1 1.3 1 0 0 1 1 1 0 Arv1-like family T2SSC PF11356.8 CDI82001.1 - 3.4 7.6 17.3 4.3 7.2 17.3 1.1 1 0 0 1 1 1 0 Type II secretion system protein C DUF4407 PF14362.6 CDI82001.1 - 4.1 6.7 24.9 0.045 13.1 16.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Kei1 PF08552.11 CDI82001.1 - 4.3 7.2 16.6 2.4 8.0 15.0 1.4 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 FlaG PF03646.15 CDI82001.1 - 4.7 7.4 24.3 2 8.6 18.3 2.3 2 0 0 2 2 2 0 FlaG protein Pannexin_like PF12534.8 CDI82001.1 - 4.8 6.2 15.8 0.91 8.5 12.5 1.5 1 1 0 1 1 1 0 Pannexin-like TM region of LRRC8 CPSF100_C PF13299.6 CDI82001.1 - 5 7.3 17.7 0.21 11.7 11.7 1.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal ATAD4 PF15321.6 CDI82001.1 - 5.6 8.4 11.9 1.8 9.9 7.6 2.0 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 MTP18 PF10558.9 CDI82001.1 - 5.9 6.8 11.3 7.9 6.4 11.3 1.3 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) ABC2_membrane_3 PF12698.7 CDI82001.1 - 6.5 5.8 11.3 7.9 5.5 11.3 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein GWT1 PF06423.12 CDI82001.1 - 7 6.8 10.1 14 5.8 10.1 1.7 1 1 0 1 1 1 0 GWT1 UPF0239 PF06783.11 CDI82001.1 - 8 6.7 13.8 9.7 6.5 9.3 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) Pex14_N PF04695.13 CDI82001.1 - 8.5 7.0 34.8 0.085 13.5 23.9 2.0 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RskA PF10099.9 CDI82007.1 - 0.0024 18.2 13.0 0.0028 18.0 13.0 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA PigN PF04987.14 CDI82007.1 - 0.08 11.8 3.8 0.076 11.9 3.8 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) ATHILA PF03078.15 CDI82007.1 - 0.11 11.3 5.0 0.11 11.2 5.0 1.0 1 0 0 1 1 1 0 ATHILA ORF-1 family Roughex PF06020.11 CDI82007.1 - 0.14 11.3 12.1 0.15 11.2 12.1 1.1 1 0 0 1 1 1 0 Drosophila roughex protein DUF4457 PF14652.6 CDI82007.1 - 0.16 11.2 5.1 0.16 11.2 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) DUF5349 PF17298.2 CDI82007.1 - 0.22 11.2 14.6 0.25 11.1 14.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5349) Med15 PF09606.10 CDI82007.1 - 0.27 9.9 26.3 0.31 9.7 26.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI82007.1 - 0.27 11.2 34.0 0.29 11.1 34.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Totivirus_coat PF05518.11 CDI82007.1 - 0.33 9.0 10.4 0.37 8.8 10.4 1.0 1 0 0 1 1 1 0 Totivirus coat protein BAF1_ABF1 PF04684.13 CDI82007.1 - 0.4 9.7 15.6 0.43 9.6 15.6 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Band_3_cyto PF07565.13 CDI82007.1 - 0.61 9.8 9.8 0.65 9.7 9.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Pex14_N PF04695.13 CDI82007.1 - 0.75 10.4 22.4 0.91 10.2 22.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Suf PF05843.14 CDI82007.1 - 0.87 9.5 17.8 0.89 9.5 17.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) THOC2_N PF16134.5 CDI82007.1 - 1 7.9 10.9 1.1 7.9 10.9 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus IHABP4_N PF16174.5 CDI82007.1 - 1 9.9 17.6 1.5 9.4 17.6 1.3 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal eIF-3_zeta PF05091.12 CDI82007.1 - 1.2 8.0 16.2 1.2 8.0 16.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Connexin PF00029.19 CDI82007.1 - 1.2 8.8 7.5 1.3 8.7 7.5 1.1 1 0 0 1 1 1 0 Connexin DUF719 PF05334.13 CDI82007.1 - 1.4 9.1 13.0 1.8 8.8 13.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF719) R_equi_Vir PF05526.11 CDI82007.1 - 1.7 8.4 10.4 1.9 8.3 10.4 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein FAM60A PF15396.6 CDI82007.1 - 1.8 8.5 11.7 1.9 8.4 11.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Spem1 PF15670.5 CDI82007.1 - 2.2 7.8 12.2 2.5 7.6 12.2 1.0 1 0 0 1 1 1 0 Spermatid maturation protein 1 FAM199X PF15814.5 CDI82007.1 - 2.4 7.2 12.4 2.8 6.9 12.4 1.0 1 0 0 1 1 1 0 Protein family FAM199X Ureide_permease PF07168.11 CDI82007.1 - 2.7 6.6 7.3 3.2 6.4 7.3 1.1 1 0 0 1 1 1 0 Ureide permease V_ATPase_I PF01496.19 CDI82007.1 - 3.2 5.6 12.0 3.1 5.6 12.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2232 PF09991.9 CDI82007.1 - 3.3 6.8 3.7 3.4 6.8 3.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) EOS1 PF12326.8 CDI82007.1 - 3.4 7.6 7.5 4 7.3 7.5 1.2 1 0 0 1 1 1 0 N-glycosylation protein Baculo_PP31 PF05311.11 CDI82007.1 - 3.7 7.0 11.5 4.1 6.8 11.5 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Astro_capsid_N PF03115.14 CDI82007.1 - 3.7 6.1 10.4 4.5 5.8 10.4 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Velvet PF11754.8 CDI82007.1 - 4 7.3 15.7 4.5 7.1 15.7 1.0 1 0 0 1 1 1 0 Velvet factor eIF3_subunit PF08597.10 CDI82007.1 - 4.1 7.3 17.2 4.5 7.1 17.2 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Neur_chan_memb PF02932.16 CDI82007.1 - 4.4 7.3 11.9 4.7 7.2 11.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1980 PF09323.10 CDI82007.1 - 4.5 7.1 8.2 5.6 6.8 8.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DivIC PF04977.15 CDI82007.1 - 4.9 7.0 16.3 8.3 6.3 16.3 1.4 1 0 0 1 1 1 0 Septum formation initiator Hydin_ADK PF17213.3 CDI82007.1 - 5 7.3 17.3 5.9 7.1 17.3 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain SelP_N PF04592.14 CDI82007.1 - 5.2 6.4 15.8 5.7 6.3 15.8 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region UPF0560 PF10577.9 CDI82007.1 - 6.1 5.2 19.0 6.4 5.1 19.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Kei1 PF08552.11 CDI82007.1 - 6.6 6.6 15.1 8.8 6.2 15.1 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 CSG2 PF16965.5 CDI82007.1 - 6.9 5.5 6.6 7.5 5.4 6.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2126 PF09899.9 CDI82007.1 - 7.3 4.5 11.1 7.8 4.4 11.1 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Zip PF02535.22 CDI82007.1 - 7.4 5.7 11.4 7.3 5.7 11.4 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Serinc PF03348.15 CDI82007.1 - 7.4 5.4 8.7 7.9 5.3 8.7 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Rtf2 PF04641.12 CDI82007.1 - 9.2 5.5 16.8 9.3 5.5 16.8 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF4569 PF15133.6 CDI82007.1 - 9.7 5.8 17.3 10 5.7 17.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) SLC12 PF03522.15 CDI82008.1 - 0.011 14.8 12.4 0.015 14.4 12.4 1.3 1 0 0 1 1 1 0 Solute carrier family 12 SARAF PF06682.12 CDI82008.1 - 0.095 12.3 16.0 0.15 11.7 16.0 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4589 PF15252.6 CDI82008.1 - 0.11 12.5 7.9 2.1 8.3 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4589) Sin_N PF04801.13 CDI82008.1 - 0.25 10.5 26.4 0.37 10.0 26.4 1.3 1 0 0 1 1 1 0 Sin-like protein conserved region SRP-alpha_N PF04086.13 CDI82008.1 - 0.43 10.5 18.9 0.72 9.7 18.9 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CDC45 PF02724.14 CDI82008.1 - 0.71 8.1 13.4 1 7.6 13.4 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4175 PF13779.6 CDI82008.1 - 1.3 6.8 45.8 2.2 6.1 45.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) AAA_23 PF13476.6 CDI82008.1 - 1.5 9.3 21.4 2.6 8.5 21.4 1.3 1 0 0 1 1 1 0 AAA domain Zip PF02535.22 CDI82008.1 - 1.6 7.8 3.9 2.3 7.4 3.9 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Folate_carrier PF01770.18 CDI82008.1 - 2.1 7.0 5.3 4.5 5.9 1.3 2.1 2 0 0 2 2 2 0 Reduced folate carrier Rtf2 PF04641.12 CDI82008.1 - 2.4 7.4 16.0 0.063 12.6 7.1 2.0 2 0 0 2 2 2 0 Rtf2 RING-finger DUF3381 PF11861.8 CDI82008.1 - 3.1 7.6 23.1 0.43 10.4 17.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Het-C PF07217.11 CDI82008.1 - 8.6 4.8 9.1 13 4.2 9.1 1.4 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C PAT1 PF09770.9 CDI82008.1 - 9.3 4.4 33.3 13 3.9 33.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AP4E_app_platf PF14807.6 CDI82012.1 - 1.5e-15 57.4 0.0 5.3e-15 55.6 0.0 2.0 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform SR-25 PF10500.9 CDI82012.1 - 0.00032 20.4 12.6 0.036 13.7 8.3 2.4 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein YL1 PF05764.13 CDI82012.1 - 0.66 10.0 5.6 0.66 10.0 2.8 2.0 2 0 0 2 2 2 0 YL1 nuclear protein DUF3782 PF12644.7 CDI82012.1 - 1.3 9.2 3.0 5.5 7.2 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3782) SRA1 PF07304.11 CDI82012.1 - 4.6 7.0 10.8 0.2 11.4 1.1 3.0 3 0 0 3 3 3 0 Steroid receptor RNA activator (SRA1) AMA-1 PF02430.15 CDI82023.1 - 2.9e-64 217.8 0.3 5.9e-64 216.7 0.1 1.6 2 0 0 2 2 2 1 Apical membrane antigen 1 FAP206 PF12018.8 CDI82023.1 - 2.7e-13 50.1 0.0 2.4e-06 27.3 0.0 3.8 3 0 0 3 3 3 3 Domain of unknown function YHS PF04945.13 CDI82023.1 - 0.00013 22.0 0.1 0.23 11.6 0.0 2.7 2 0 0 2 2 2 2 YHS domain Spt20 PF12090.8 CDI82027.1 - 0.0088 15.7 16.7 0.0088 15.7 16.7 1.5 2 0 0 2 2 2 1 Spt20 family EIF4E-T PF10477.9 CDI82027.1 - 0.043 12.7 4.4 0.045 12.6 4.4 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF4446 PF14584.6 CDI82027.1 - 0.06 13.3 0.2 0.078 13.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) TFIIA PF03153.13 CDI82027.1 - 0.16 11.9 26.9 0.23 11.4 26.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI82027.1 - 0.46 10.8 38.7 63 3.8 38.7 2.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA GET2 PF08690.10 CDI82027.1 - 1.9 8.1 8.8 2.1 7.9 8.3 1.3 1 1 0 1 1 1 0 GET complex subunit GET2 Atrophin-1 PF03154.15 CDI82027.1 - 5 5.3 22.5 6.4 4.9 22.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family PAP2 PF01569.21 CDI82031.1 - 0.00031 20.5 0.3 0.0032 17.2 0.3 1.9 1 1 0 1 1 1 1 PAP2 superfamily DUF3995 PF13160.6 CDI82031.1 - 0.0025 18.1 2.0 0.0025 18.1 2.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3995) SARAF PF06682.12 CDI82031.1 - 0.028 14.1 0.2 0.033 13.8 0.2 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4131 PF13567.6 CDI82031.1 - 0.19 11.4 4.8 0.072 12.7 1.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) TFIIA PF03153.13 CDI82031.1 - 0.49 10.3 13.3 0.71 9.8 13.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SARG PF15385.6 CDI82031.1 - 1.4 8.1 10.7 2.1 7.5 10.7 1.4 1 1 0 1 1 1 0 Specifically androgen-regulated gene protein IER PF05760.12 CDI82031.1 - 2.2 8.5 8.5 2.9 8.1 8.5 1.1 1 0 0 1 1 1 0 Immediate early response protein (IER) DUF3138 PF11336.8 CDI82031.1 - 3.1 6.3 11.7 4 5.9 11.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3138) Phostensin_N PF13916.6 CDI82031.1 - 3.2 8.2 8.3 11 6.5 1.4 2.4 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal SUIM_assoc PF16619.5 CDI82031.1 - 4.9 7.3 25.8 1.1 9.4 5.3 2.7 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Nop14 PF04147.12 CDI82033.1 - 0.00034 19.0 9.4 0.00045 18.6 9.4 1.0 1 0 0 1 1 1 1 Nop14-like family RskA PF10099.9 CDI82033.1 - 0.00037 20.8 8.6 0.00051 20.4 8.6 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA SDA1 PF05285.12 CDI82033.1 - 0.008 15.7 7.7 0.01 15.3 7.7 1.1 1 0 0 1 1 1 1 SDA1 CAP_N PF01213.19 CDI82033.1 - 0.033 13.7 10.8 0.049 13.1 10.8 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 CDI82033.1 - 0.06 13.4 3.9 0.092 12.8 3.9 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.5 CDI82033.1 - 0.16 12.0 13.6 0.077 13.0 9.9 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 CDC45 PF02724.14 CDI82033.1 - 1.4 7.1 10.9 1.7 6.8 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein MDM1 PF15501.6 CDI82033.1 - 3.5 6.7 14.1 4.5 6.3 14.1 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 Prothymosin PF03247.14 CDI82033.1 - 5.9 7.4 32.6 11 6.5 32.6 1.4 1 0 0 1 1 1 0 Prothymosin/parathymosin family DUF1180 PF06679.12 CDI82033.1 - 7.2 7.0 9.3 0.24 11.8 3.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Connexin PF00029.19 CDI82034.1 - 0.0049 16.7 5.8 0.0055 16.5 5.8 1.0 1 0 0 1 1 1 1 Connexin CPSF100_C PF13299.6 CDI82034.1 - 0.015 15.4 9.7 0.016 15.4 9.7 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4484 PF14831.6 CDI82034.1 - 0.029 14.4 11.3 0.035 14.2 11.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) AIF_C PF14721.6 CDI82034.1 - 0.05 14.0 6.1 0.058 13.8 6.1 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CobT PF06213.12 CDI82034.1 - 0.058 12.8 24.7 0.064 12.6 24.7 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TFB6 PF17110.5 CDI82034.1 - 0.11 12.2 10.1 0.13 12.0 10.1 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Eapp_C PF10238.9 CDI82034.1 - 0.17 12.0 6.7 0.18 11.8 6.7 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein GEN1_C PF18380.1 CDI82034.1 - 0.18 12.7 11.8 0.25 12.2 11.8 1.3 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain Afi1 PF07792.12 CDI82034.1 - 0.27 11.7 10.6 0.31 11.5 10.6 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FHIPEP PF00771.20 CDI82034.1 - 0.28 9.6 5.0 0.31 9.5 5.0 1.0 1 0 0 1 1 1 0 FHIPEP family PIP5K PF01504.18 CDI82034.1 - 0.36 10.0 3.6 0.37 10.0 3.6 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase BUD22 PF09073.10 CDI82034.1 - 0.37 10.1 21.2 0.4 10.0 21.2 1.0 1 0 0 1 1 1 0 BUD22 DUF913 PF06025.12 CDI82034.1 - 0.39 9.7 8.2 0.4 9.6 8.2 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SpoIIP PF07454.11 CDI82034.1 - 0.49 9.8 12.8 0.54 9.7 12.8 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Sigma70_ner PF04546.13 CDI82034.1 - 0.77 9.6 23.1 0.94 9.3 23.1 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region ATP-synt_E PF05680.12 CDI82034.1 - 0.78 10.1 14.0 1.1 9.6 14.0 1.3 1 0 0 1 1 1 0 ATP synthase E chain RNA_pol_Rpc4 PF05132.14 CDI82034.1 - 0.81 10.1 10.8 0.94 9.9 10.8 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Ureide_permease PF07168.11 CDI82034.1 - 0.86 8.3 4.2 1 8.1 4.2 1.0 1 0 0 1 1 1 0 Ureide permease DUF5523 PF17661.1 CDI82034.1 - 1 9.0 25.3 1.1 8.9 25.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) EIIBC-GUT_N PF03612.14 CDI82034.1 - 1 9.1 7.2 1.3 8.8 7.2 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CLN3 PF02487.17 CDI82034.1 - 1 8.3 5.9 1.2 8.1 5.9 1.0 1 0 0 1 1 1 0 CLN3 protein Presenilin PF01080.17 CDI82034.1 - 1.2 7.8 10.9 1.4 7.6 10.9 1.0 1 0 0 1 1 1 0 Presenilin Coilin_N PF15862.5 CDI82034.1 - 1.3 8.8 9.0 1.5 8.6 9.0 1.1 1 0 0 1 1 1 0 Coilin N-terminus Tim54 PF11711.8 CDI82034.1 - 1.3 7.7 15.1 1.5 7.5 15.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DDHD PF02862.17 CDI82034.1 - 1.3 9.1 6.4 1.4 9.0 6.4 1.0 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.14 CDI82034.1 - 1.4 7.1 20.9 1.5 7.0 20.9 1.0 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 CDI82034.1 - 1.4 7.6 9.3 1.5 7.5 9.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PPL5 PF18168.1 CDI82034.1 - 1.4 8.1 6.2 1.5 8.0 6.2 1.0 1 0 0 1 1 1 0 Prim-pol family 5 DUF789 PF05623.12 CDI82034.1 - 1.5 8.4 5.2 1.6 8.4 5.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF789) SLC12 PF03522.15 CDI82034.1 - 1.5 7.7 5.0 1.7 7.6 5.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SID-1_RNA_chan PF13965.6 CDI82034.1 - 1.6 7.1 4.2 1.6 7.1 4.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 CDI82034.1 - 1.8 7.4 2.6 1.8 7.4 2.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2828 PF11443.8 CDI82034.1 - 2.2 6.3 7.2 2.5 6.1 7.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Paf1 PF03985.13 CDI82034.1 - 2.2 7.2 32.3 2.6 7.0 32.3 1.0 1 0 0 1 1 1 0 Paf1 Zip PF02535.22 CDI82034.1 - 2.3 7.4 8.8 2.5 7.2 8.8 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Serinc PF03348.15 CDI82034.1 - 2.4 7.0 5.8 2.4 7.0 5.8 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Pox_Ag35 PF03286.14 CDI82034.1 - 2.9 7.7 21.4 3.4 7.4 21.4 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 CDI82034.1 - 2.9 5.9 35.1 3.2 5.7 35.1 1.0 1 0 0 1 1 1 0 DNA polymerase phi FYDLN_acid PF09538.10 CDI82034.1 - 2.9 8.6 19.8 4.3 8.1 19.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF2428 PF10350.9 CDI82034.1 - 3.1 7.0 7.7 3.3 6.9 7.7 1.1 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) TERB2 PF15101.6 CDI82034.1 - 3.1 7.8 6.2 3.2 7.7 6.2 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF2052 PF09747.9 CDI82034.1 - 3.3 7.8 26.9 5.1 7.2 26.9 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) MRNIP PF15749.5 CDI82034.1 - 3.4 8.5 11.7 4.7 8.0 11.7 1.3 1 0 0 1 1 1 0 MRN-interacting protein GNAT_acetyltr_2 PF13718.6 CDI82034.1 - 3.6 6.9 8.5 4.1 6.7 8.5 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 FemAB PF02388.16 CDI82034.1 - 3.7 6.3 8.9 4.1 6.2 8.9 1.0 1 0 0 1 1 1 0 FemAB family Saw1 PF11561.8 CDI82034.1 - 3.8 7.0 7.2 4.7 6.7 7.2 1.3 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Folate_carrier PF01770.18 CDI82034.1 - 3.8 6.1 4.6 3.9 6.1 4.6 1.1 1 0 0 1 1 1 0 Reduced folate carrier DUF2722 PF10846.8 CDI82034.1 - 4.3 6.2 9.5 4.6 6.1 9.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Vfa1 PF08432.10 CDI82034.1 - 4.6 7.5 16.9 5.4 7.3 16.9 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Utp14 PF04615.13 CDI82034.1 - 4.8 5.6 21.6 5.4 5.5 21.6 1.0 1 0 0 1 1 1 0 Utp14 protein Hid1 PF12722.7 CDI82034.1 - 4.9 5.2 8.3 5.2 5.1 8.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3391 PF11871.8 CDI82034.1 - 6.1 7.4 13.7 7.9 7.0 13.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) D123 PF07065.14 CDI82034.1 - 6.2 5.9 10.2 7.3 5.7 10.2 1.2 1 0 0 1 1 1 0 D123 ALMT PF11744.8 CDI82034.1 - 6.2 5.5 6.7 7 5.4 6.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter O-antigen_lig PF13425.6 CDI82034.1 - 6.3 5.5 6.9 6.5 5.4 6.9 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Mpp10 PF04006.12 CDI82034.1 - 6.4 5.1 31.3 7.4 4.9 31.3 1.0 1 0 0 1 1 1 0 Mpp10 protein DUF4820 PF16091.5 CDI82034.1 - 6.5 6.0 16.3 7.2 5.9 16.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) SAPS PF04499.15 CDI82034.1 - 6.5 5.4 11.3 7.2 5.3 11.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TRM13 PF05206.14 CDI82034.1 - 6.8 6.1 7.2 7.8 5.9 7.2 1.2 1 0 0 1 1 1 0 Methyltransferase TRM13 ADP_ribosyl_GH PF03747.14 CDI82034.1 - 7.1 6.3 5.4 7.6 6.2 5.4 1.0 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase V_ATPase_I PF01496.19 CDI82034.1 - 7.2 4.4 13.2 7.9 4.3 13.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DDRGK PF09756.9 CDI82034.1 - 8.8 5.9 29.7 10 5.7 29.7 1.1 1 0 0 1 1 1 0 DDRGK domain RED_N PF07808.13 CDI82043.1 - 0.00071 19.2 4.4 0.00071 19.2 4.4 2.1 2 0 0 2 2 2 1 RED-like protein N-terminal region RskA PF10099.9 CDI82043.1 - 0.00075 19.8 46.0 0.022 15.1 24.3 2.2 1 1 1 2 2 2 2 Anti-sigma-K factor rskA FlxA PF14282.6 CDI82043.1 - 0.0021 18.0 23.7 0.0021 18.0 23.7 2.3 2 0 0 2 2 2 1 FlxA-like protein TFIIA PF03153.13 CDI82043.1 - 0.06 13.3 32.6 0.014 15.4 18.8 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit MCU PF04678.13 CDI82043.1 - 0.12 12.4 11.2 0.071 13.2 6.0 2.1 2 0 0 2 2 2 0 Mitochondrial calcium uniporter LMBR1 PF04791.16 CDI82043.1 - 0.3 10.0 2.0 0.39 9.6 2.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein OmpH PF03938.14 CDI82043.1 - 0.47 10.8 33.5 0.052 13.9 16.8 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Activator_LAG-3 PF11498.8 CDI82043.1 - 0.52 9.2 40.1 0.012 14.6 13.9 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI82043.1 - 0.65 9.6 30.8 0.1 12.2 14.0 2.1 2 0 0 2 2 2 0 Spt20 family DUF2722 PF10846.8 CDI82043.1 - 1 8.3 21.7 0.025 13.5 7.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Noggin PF05806.12 CDI82043.1 - 2.2 8.2 5.4 9.9 6.0 0.4 2.1 2 0 0 2 2 2 0 Noggin Muted PF14942.6 CDI82043.1 - 2.4 8.5 17.6 0.47 10.8 6.6 2.1 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein DUF4355 PF14265.6 CDI82043.1 - 4.1 7.7 21.9 0.56 10.5 10.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) DUF4834 PF16118.5 CDI82043.1 - 4.8 8.2 9.2 12 6.9 3.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ndc1_Nup PF09531.10 CDI82043.1 - 6.4 5.3 12.2 8.9 4.9 12.2 1.3 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GET2 PF08690.10 CDI82043.1 - 9.6 5.8 14.5 0.46 10.1 7.4 2.0 2 0 0 2 2 2 0 GET complex subunit GET2 Nop53 PF07767.11 CDI82045.1 - 0.047 13.1 33.8 0.057 12.8 33.8 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) AF-4 PF05110.13 CDI82045.1 - 0.2 9.7 50.2 0.26 9.3 50.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SprA-related PF12118.8 CDI82045.1 - 0.23 10.6 52.8 0.29 10.2 52.8 1.1 1 0 0 1 1 1 0 SprA-related family CCSAP PF15748.5 CDI82045.1 - 0.54 10.4 42.8 0.67 10.1 42.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated RR_TM4-6 PF06459.12 CDI82045.1 - 4.4 7.0 32.4 7.8 6.2 32.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RAP1 PF07218.11 CDI82045.1 - 5.6 5.1 17.3 6.6 4.9 17.3 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) TFIIA PF03153.13 CDI82045.1 - 6.3 6.7 59.2 9.3 6.1 59.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PA26 PF04636.13 CDI82045.1 - 7 5.5 26.7 8.8 5.1 26.7 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF5523 PF17661.1 CDI82045.1 - 8.9 5.9 31.5 11 5.6 31.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF4366 PF14283.6 CDI82049.1 - 2.6 8.1 6.4 3.9 7.5 6.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) VIR_N PF15912.5 CDI82054.1 - 0.17 11.5 19.3 0.22 11.1 19.3 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal GREB1 PF15782.5 CDI82054.1 - 1.1 6.2 42.4 1.3 6.1 42.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RR_TM4-6 PF06459.12 CDI82054.1 - 1.2 8.9 31.2 1.5 8.6 31.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Macoilin PF09726.9 CDI82054.1 - 1.4 7.4 34.9 1.6 7.2 34.9 1.0 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 CDI82054.1 - 1.5 7.5 39.1 1.7 7.3 39.1 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 CDI82054.1 - 1.5 7.0 25.4 1.7 6.9 25.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Lin-8 PF03353.15 CDI82054.1 - 1.7 8.1 38.5 2.8 7.4 38.5 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist WTX PF09422.10 CDI82054.1 - 2.3 7.2 29.8 2.7 7.0 29.8 1.0 1 0 0 1 1 1 0 WTX protein MAP7 PF05672.11 CDI82054.1 - 2.5 7.8 40.9 3.2 7.4 40.9 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family RskA PF10099.9 CDI82054.1 - 2.5 8.4 27.1 1.4e+04 -3.8 27.1 2.5 1 1 0 1 1 0 0 Anti-sigma-K factor rskA Cellulose_synt PF03552.14 CDI82054.1 - 3.1 6.2 10.3 3.2 6.1 10.3 1.0 1 0 0 1 1 1 0 Cellulose synthase SLC12 PF03522.15 CDI82054.1 - 3.1 6.7 32.4 3.5 6.6 32.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SID-1_RNA_chan PF13965.6 CDI82054.1 - 3.3 6.0 12.6 4.3 5.6 12.6 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2052 PF09747.9 CDI82054.1 - 3.6 7.7 26.1 4.6 7.3 26.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) VIT1 PF01988.19 CDI82054.1 - 4.2 7.2 14.4 5.7 6.7 14.4 1.3 1 0 0 1 1 1 0 VIT family NARP1 PF12569.8 CDI82054.1 - 4.3 6.1 28.1 5.4 5.8 28.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 ALMT PF11744.8 CDI82054.1 - 4.7 5.9 26.4 5.5 5.7 26.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 CDI82054.1 - 4.8 6.3 33.1 6.8 5.8 33.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Membralin PF09746.9 CDI82054.1 - 7.7 5.4 19.5 9.1 5.2 19.5 1.2 1 0 0 1 1 1 0 Tumour-associated protein Peptidase_S15 PF02129.18 CDI82054.1 - 9.8 5.7 25.2 13 5.3 25.2 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) RskA PF10099.9 CDI82056.1 - 0.0082 16.5 3.6 0.0082 16.5 3.6 6.0 1 1 3 4 4 4 2 Anti-sigma-K factor rskA DUF3523 PF12037.8 CDI82060.1 - 2.6 7.3 52.1 3.4 7.0 52.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) SAGA-Tad1 PF12767.7 CDI82062.1 - 6.4e-06 26.1 5.9 0.0015 18.3 1.2 3.1 3 0 0 3 3 3 2 Transcriptional regulator of RNA polII, SAGA, subunit DUF4667 PF15700.5 CDI82062.1 - 8.3e-06 26.1 23.5 0.015 15.4 4.0 3.4 3 0 0 3 3 3 3 Domain of unknown function (DUF4667) Apt1 PF10351.9 CDI82062.1 - 0.2 10.5 17.3 0.14 10.9 1.5 3.1 3 0 0 3 3 3 0 Golgi-body localisation protein domain DUF2464 PF10240.9 CDI82062.1 - 5.5 6.5 8.5 0.25 10.9 0.6 2.6 3 0 0 3 3 3 0 Multivesicular body subunit 12 Secretin_N_2 PF07655.13 CDI82062.1 - 6.3 7.4 42.2 5.2 7.7 6.8 3.7 3 0 0 3 3 3 0 Secretin N-terminal domain TPR_8 PF13181.6 CDI82063.1 - 0.14 12.4 0.1 0.48 10.8 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDI82063.1 - 0.15 12.2 0.3 0.42 10.9 0.3 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF2722 PF10846.8 CDI82064.1 - 3.7e-05 22.9 8.0 3.7e-05 22.9 8.0 5.4 4 1 1 5 5 5 3 Protein of unknown function (DUF2722) DUF4834 PF16118.5 CDI82064.1 - 0.085 13.8 0.8 0.085 13.8 0.8 5.5 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) RskA PF10099.9 CDI82065.1 - 0.002 18.4 6.6 0.0041 17.4 6.1 1.8 1 1 0 1 1 1 1 Anti-sigma-K factor rskA Spc7 PF08317.11 CDI82065.1 - 0.13 11.2 14.9 0.21 10.4 14.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3080 PF11279.8 CDI82065.1 - 0.13 11.5 9.4 0.11 11.7 8.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3080) YabA PF06156.13 CDI82065.1 - 0.36 11.5 10.4 2.9 8.6 2.3 2.4 1 1 1 2 2 2 0 Initiation control protein YabA CtIP_N PF10482.9 CDI82065.1 - 0.49 10.5 12.8 0.79 9.8 12.8 1.3 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain PRKG1_interact PF15898.5 CDI82065.1 - 0.67 10.9 18.2 0.18 12.7 13.2 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain KASH_CCD PF14662.6 CDI82065.1 - 1 9.1 19.6 0.16 11.8 8.5 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH HALZ PF02183.18 CDI82065.1 - 1.7 9.0 16.0 0.13 12.5 0.9 3.3 2 2 1 3 3 3 0 Homeobox associated leucine zipper UPF0449 PF15136.6 CDI82065.1 - 1.7 9.2 10.3 4.2 7.9 3.2 2.5 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 GAS PF13851.6 CDI82065.1 - 1.7 7.9 16.4 19 4.5 16.5 2.3 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF1003 PF06210.11 CDI82065.1 - 5.1 7.2 8.6 6.1 7.0 1.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1003) IFT20 PF14931.6 CDI82065.1 - 6 7.1 13.2 20 5.4 6.6 2.8 1 1 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 bZIP_1 PF00170.21 CDI82065.1 - 6.1 7.0 15.7 2.6 8.2 0.9 3.5 2 1 1 3 3 3 0 bZIP transcription factor ZapB PF06005.12 CDI82065.1 - 6.4 7.3 23.5 15 6.1 17.2 3.0 1 1 1 2 2 2 0 Cell division protein ZapB V_ATPase_I PF01496.19 CDI82065.1 - 10 3.9 6.0 13 3.5 6.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2722 PF10846.8 CDI82067.1 - 0.00077 18.5 7.6 0.00077 18.5 7.6 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) SR-25 PF10500.9 CDI82067.1 - 0.0088 15.7 21.4 0.012 15.3 4.8 2.1 1 1 1 2 2 2 2 Nuclear RNA-splicing-associated protein FmiP_Thoc5 PF09766.9 CDI82067.1 - 0.074 12.3 17.7 0.044 13.1 5.5 2.1 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 PEX11 PF05648.14 CDI82067.1 - 0.074 12.5 10.1 0.25 10.8 1.0 2.2 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) DUF4079 PF13301.6 CDI82067.1 - 0.28 11.3 12.5 1.4 9.1 2.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) tRNA_lig_CPD PF08302.11 CDI82067.1 - 0.28 10.6 17.1 1.2 8.5 6.4 2.2 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain DUF2207 PF09972.9 CDI82067.1 - 0.35 9.6 4.5 2.4 6.8 1.5 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 CDI82067.1 - 0.36 11.7 10.5 1.1 10.1 2.4 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TFB6 PF17110.5 CDI82067.1 - 0.77 9.5 7.1 1.3 8.7 1.4 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF4064 PF13273.6 CDI82067.1 - 1.1 9.5 12.1 0.54 10.6 1.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) ISK_Channel PF02060.15 CDI82067.1 - 1.7 8.3 6.6 0.16 11.7 0.7 2.1 2 0 0 2 2 2 0 Slow voltage-gated potassium channel MDM31_MDM32 PF08118.11 CDI82067.1 - 2.2 6.9 11.5 0.24 10.0 2.5 2.2 2 0 0 2 2 2 0 Yeast mitochondrial distribution and morphology (MDM) proteins Coilin_N PF15862.5 CDI82067.1 - 3.2 7.5 26.0 6.3 6.6 13.1 2.3 2 0 0 2 2 2 0 Coilin N-terminus Spem1 PF15670.5 CDI82067.1 - 3.3 7.2 15.1 3.9 7.0 1.9 2.1 2 0 0 2 2 2 0 Spermatid maturation protein 1 Hamartin PF04388.12 CDI82067.1 - 3.9 6.0 25.3 5 5.7 25.3 1.1 1 0 0 1 1 1 0 Hamartin protein RICTOR_N PF14664.6 CDI82067.1 - 5 6.0 10.6 1.6 7.6 3.6 2.0 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term Mak10 PF04112.13 CDI82067.1 - 5.2 6.5 11.4 2.3 7.7 1.0 2.2 2 0 0 2 2 2 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Tau95_N PF17682.1 CDI82067.1 - 6.1 7.1 10.0 11 6.2 3.0 2.3 2 0 0 2 2 2 0 Tau95 Triple barrel domain Acatn PF13000.7 CDI82067.1 - 6.7 5.1 6.2 0.44 9.0 1.0 1.5 2 0 0 2 2 2 0 Acetyl-coenzyme A transporter 1 DUF4471 PF14740.6 CDI82067.1 - 8 5.6 11.9 8 5.6 4.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) DUF2387 PF09526.10 CDI82067.1 - 8.9 6.6 12.6 1.2 9.3 0.6 2.8 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) HC2 PF07382.11 CDI82068.1 - 8.1e-05 22.8 15.8 8.1e-05 22.8 15.8 2.4 2 0 0 2 2 2 1 Histone H1-like nucleoprotein HC2 RskA PF10099.9 CDI82068.1 - 0.0091 16.3 29.6 0.053 13.8 8.3 3.2 2 1 1 3 3 3 3 Anti-sigma-K factor rskA BUD22 PF09073.10 CDI82068.1 - 0.02 14.3 59.3 0.022 14.1 10.6 2.4 2 1 0 2 2 2 0 BUD22 Adaptin_binding PF10199.9 CDI82069.1 - 0.0033 18.0 0.0 0.019 15.6 0.0 2.1 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 SR-25 PF10500.9 CDI82069.1 - 4.3 6.9 25.8 0.48 10.0 21.5 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SOBP PF15279.6 CDI82069.1 - 9.7 6.7 20.1 12 6.3 20.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein PIP5K PF01504.18 CDI82071.1 - 1.5 8.0 8.0 1.6 7.9 8.0 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Ant_C PF05586.11 CDI82071.1 - 2.3 8.9 7.4 1.9 9.2 1.7 2.0 2 0 0 2 2 2 0 Anthrax receptor C-terminus region Presenilin PF01080.17 CDI82071.1 - 2.3 6.9 12.2 2.9 6.6 12.2 1.2 1 0 0 1 1 1 0 Presenilin Peptidase_S49_N PF08496.10 CDI82071.1 - 5.6 7.0 10.5 2.7 8.0 5.1 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal CDK2AP PF09806.9 CDI82071.1 - 8.2 6.4 15.0 9.7 6.2 15.0 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein PsaL PF02605.15 CDI82071.1 - 9.3 5.9 7.8 1.3 8.7 1.7 1.9 1 1 1 2 2 2 0 Photosystem I reaction centre subunit XI CelTOS PF18659.1 CDI82072.1 - 0.18 12.3 2.4 0.37 11.3 2.4 1.5 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites RskA PF10099.9 CDI82072.1 - 0.24 11.7 14.9 0.042 14.2 6.1 2.4 2 1 0 2 2 2 0 Anti-sigma-K factor rskA CBFD_NFYB_HMF PF00808.23 CDI82072.1 - 0.56 10.5 14.6 1.4e+03 -0.4 14.6 2.7 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Spo0A_C PF08769.11 CDI82072.1 - 3.1 7.9 8.4 0.26 11.4 3.4 1.7 2 0 0 2 2 2 0 Sporulation initiation factor Spo0A C terminal DUF445 PF04286.12 CDI82072.1 - 7.9 6.2 12.9 1.3 8.7 9.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF445) Hamartin PF04388.12 CDI82072.1 - 8.1 5.0 37.3 12 4.4 37.3 1.2 1 0 0 1 1 1 0 Hamartin protein Activator_LAG-3 PF11498.8 CDI82102.1 - 0.00017 20.7 10.2 0.00017 20.7 10.2 16.9 6 4 10 17 17 17 1 Transcriptional activator LAG-3 SARAF PF06682.12 CDI82104.1 - 0.0017 18.1 8.9 0.0017 18.1 8.9 3.4 3 1 0 3 3 3 1 SOCE-associated regulatory factor of calcium homoeostasis Otopetrin PF03189.13 CDI82104.1 - 0.0049 15.8 0.0 0.22 10.3 0.0 3.0 2 1 0 2 2 2 1 Otopetrin CrgA PF06781.12 CDI82104.1 - 0.082 13.0 0.2 0.082 13.0 0.2 4.1 3 1 1 4 4 4 0 Cell division protein CrgA PAT1 PF09770.9 CDI82104.1 - 0.15 10.3 47.2 0.0089 14.4 26.4 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 FAM209 PF15206.6 CDI82104.1 - 0.4 10.5 3.9 1.4 8.7 3.9 2.0 1 1 0 1 1 1 0 FAM209 family Serinc PF03348.15 CDI82104.1 - 0.49 9.3 13.2 0.036 13.0 5.6 2.5 2 0 0 2 2 2 0 Serine incorporator (Serinc) DUF2207 PF09972.9 CDI82104.1 - 2.6 6.7 4.6 0.59 8.8 0.1 2.1 2 1 1 3 3 3 0 Predicted membrane protein (DUF2207) DUF2828 PF11443.8 CDI82104.1 - 2.6 6.0 20.7 0.34 8.9 10.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) SID-1_RNA_chan PF13965.6 CDI82104.1 - 4.1 5.7 13.3 0.041 12.3 4.3 1.9 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF4079 PF13301.6 CDI82104.1 - 4.4 7.5 5.9 1e+02 3.0 5.0 3.3 2 2 0 2 2 2 0 Protein of unknown function (DUF4079) CCSAP PF15748.5 CDI82104.1 - 6.5 6.8 39.8 0.028 14.6 12.6 3.1 2 1 0 2 2 2 0 Centriole, cilia and spindle-associated Orf78 PF06024.12 CDI82104.1 - 9.2 6.6 24.7 0.042 14.1 1.9 4.9 3 1 1 4 4 3 0 Orf78 (ac78) RRM_1 PF00076.22 CDI82105.1 - 2.5e-16 59.3 0.0 4.3e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 CDI82105.1 - 0.00034 20.8 35.2 0.00039 20.6 35.2 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit AAA_23 PF13476.6 CDI82105.1 - 0.0033 18.0 7.5 0.0041 17.6 7.5 1.2 1 0 0 1 1 1 1 AAA domain Connexin PF00029.19 CDI82105.1 - 0.19 11.4 3.8 0.24 11.1 3.8 1.3 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 CDI82105.1 - 1.9 7.1 16.2 2.6 6.7 16.2 1.3 1 0 0 1 1 1 0 Presenilin SR-25 PF10500.9 CDI82113.1 - 0.0024 17.5 15.2 0.0059 16.3 15.2 1.6 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4366 PF14283.6 CDI82119.1 - 0.0064 16.5 6.1 0.0064 16.5 6.1 3.8 2 2 1 3 3 3 1 Domain of unknown function (DUF4366) Neur_chan_memb PF02932.16 CDI82119.1 - 0.97 9.4 17.7 0.31 11.0 6.4 2.7 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region LMBR1 PF04791.16 CDI82119.1 - 1.4 7.8 5.0 1.8 7.4 5.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3452 PF11934.8 CDI82119.1 - 1.6 8.3 12.1 30 4.2 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3452) HCO3_cotransp PF00955.21 CDI82119.1 - 3.9 6.2 5.4 9 5.0 5.4 1.5 1 0 0 1 1 1 0 HCO3- transporter family Mem_trans PF03547.18 CDI82119.1 - 8.4 4.7 8.7 3.2 6.0 0.4 2.5 2 0 0 2 2 2 0 Membrane transport protein PDDEXK_6 PF04720.12 CDI82125.1 - 0.11 12.4 0.1 0.11 12.4 0.1 1.9 2 0 0 2 2 2 0 PDDEXK-like family of unknown function Trypan_PARP PF05887.11 CDI82127.1 - 0.0047 16.9 15.1 0.0047 16.9 15.1 2.3 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) RskA PF10099.9 CDI82127.1 - 0.019 15.2 0.4 0.019 15.2 0.4 2.4 1 1 1 2 2 2 0 Anti-sigma-K factor rskA K_channel_TID PF07941.11 CDI82127.1 - 0.037 14.5 7.3 0.037 14.5 7.3 5.8 2 1 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain PepSY_2 PF13670.6 CDI82127.1 - 0.044 13.8 1.6 0.14 12.2 1.6 1.9 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain PRP38_assoc PF12871.7 CDI82127.1 - 1 10.0 85.7 1.8e+04 -11.4 85.7 2.9 1 1 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF4179 PF13786.6 CDI82130.1 - 0.56 10.7 0.0 0.56 10.7 0.0 6.1 5 2 0 5 5 5 0 Domain of unknown function (DUF4179) eIF-3_zeta PF05091.12 CDI82130.1 - 0.76 8.7 20.4 0.012 14.6 8.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4746 PF15928.5 CDI82130.1 - 1.2 8.5 6.5 1.8 7.9 4.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) EMC3_TMCO1 PF01956.16 CDI82130.1 - 2.7 7.7 6.8 5 6.8 6.8 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Plasmodium_Vir PF05795.11 CDI82130.1 - 8.9 5.6 31.2 0.54 9.6 8.6 2.6 2 0 0 2 2 2 0 Plasmodium vivax Vir protein HTH_26 PF13443.6 CDI82132.1 - 0.062 13.7 0.3 9.2 6.8 0.0 2.3 1 1 1 2 2 2 0 Cro/C1-type HTH DNA-binding domain DUF1980 PF09323.10 CDI82133.1 - 0.0023 17.9 4.3 0.0023 17.9 4.3 5.0 3 1 0 3 3 3 2 Domain of unknown function (DUF1980) Hamartin PF04388.12 CDI82157.1 - 0.002 16.9 49.4 0.0023 16.7 49.4 1.1 1 0 0 1 1 1 1 Hamartin protein Pex14_N PF04695.13 CDI82158.1 - 0.013 16.2 22.5 0.017 15.7 22.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SWIRM-assoc_2 PF16496.5 CDI82158.1 - 0.029 13.3 12.9 0.034 13.0 12.9 1.0 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal DUF4658 PF15555.6 CDI82158.1 - 0.042 14.0 1.3 0.073 13.2 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) EIF4E-T PF10477.9 CDI82158.1 - 0.05 12.4 20.3 0.051 12.4 20.3 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Lin-8 PF03353.15 CDI82158.1 - 0.063 12.8 21.7 0.069 12.7 21.7 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2367 PF10164.9 CDI82158.1 - 0.16 12.5 10.2 0.45 11.0 10.2 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) RIFIN PF02009.16 CDI82158.1 - 0.19 11.6 12.0 0.21 11.4 12.0 1.1 1 0 0 1 1 1 0 Rifin TFIIA PF03153.13 CDI82158.1 - 0.19 11.7 35.3 0.23 11.4 35.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SAPS PF04499.15 CDI82158.1 - 0.32 9.7 15.3 0.38 9.5 15.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MMU163 PF17119.5 CDI82158.1 - 0.32 10.1 6.6 0.39 9.9 6.6 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Pox_Ag35 PF03286.14 CDI82158.1 - 0.36 10.6 15.9 0.47 10.2 15.9 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Suf PF05843.14 CDI82158.1 - 0.39 10.7 27.7 0.48 10.4 27.7 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) XRCC4 PF06632.12 CDI82158.1 - 0.49 9.2 18.9 0.59 8.9 18.9 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF1387 PF07139.11 CDI82158.1 - 1 9.0 18.6 1.2 8.8 18.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF4045 PF13254.6 CDI82158.1 - 1 8.9 21.7 1.2 8.7 21.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Herpes_UL74 PF07982.12 CDI82158.1 - 1 8.2 5.9 1.3 7.9 5.9 1.1 1 0 0 1 1 1 0 Herpes UL74 glycoproteins DUF572 PF04502.13 CDI82158.1 - 1.5 8.4 21.5 1.7 8.2 21.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Hydin_ADK PF17213.3 CDI82158.1 - 1.6 9.0 14.3 1.9 8.7 14.3 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain FAM60A PF15396.6 CDI82158.1 - 1.6 8.7 12.2 2.1 8.3 12.2 1.4 1 0 0 1 1 1 0 Protein Family FAM60A eIF-3_zeta PF05091.12 CDI82158.1 - 1.7 7.6 20.0 1.9 7.4 20.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) HCO3_cotransp PF00955.21 CDI82158.1 - 1.8 7.3 5.1 1.8 7.3 5.1 1.2 1 0 0 1 1 1 0 HCO3- transporter family PAT1 PF09770.9 CDI82158.1 - 1.8 6.7 28.2 2 6.6 28.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2052 PF09747.9 CDI82158.1 - 3 7.9 22.2 4.3 7.4 22.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Band_3_cyto PF07565.13 CDI82158.1 - 3 7.6 13.7 3.9 7.2 13.7 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Nop53 PF07767.11 CDI82158.1 - 3.6 6.9 27.6 4 6.7 27.6 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) BSP_II PF05432.11 CDI82158.1 - 3.7 7.2 18.4 4.2 7.0 18.4 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) GREB1 PF15782.5 CDI82158.1 - 3.9 4.5 19.6 4.2 4.4 19.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 CDI82158.1 - 4.2 7.4 13.7 4.9 7.1 13.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.17 CDI82158.1 - 4.3 7.4 16.6 5.5 7.1 16.6 1.2 1 0 0 1 1 1 0 DDHD domain Hid1 PF12722.7 CDI82158.1 - 4.9 5.2 23.5 5.5 5.0 23.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4569 PF15133.6 CDI82158.1 - 5.1 6.7 20.1 6.4 6.4 20.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Rrn6 PF10214.9 CDI82158.1 - 5.2 5.4 20.1 5.7 5.3 20.1 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CDC45 PF02724.14 CDI82158.1 - 5.3 5.2 20.4 6.1 5.0 20.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI82158.1 - 6 5.5 23.1 7.3 5.3 23.1 1.1 1 0 0 1 1 1 0 Presenilin Podoplanin PF05808.11 CDI82158.1 - 6.2 6.9 11.3 7.9 6.6 11.3 1.1 1 0 0 1 1 1 0 Podoplanin NARP1 PF12569.8 CDI82158.1 - 6.5 5.5 20.3 7.7 5.3 20.3 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FAM70 PF14967.6 CDI82158.1 - 7 6.0 8.4 7.5 5.9 8.4 1.1 1 0 0 1 1 1 0 FAM70 protein SLC12 PF03522.15 CDI82158.1 - 7.9 5.4 20.9 9 5.2 20.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Membralin PF09746.9 CDI82158.1 - 8.1 5.4 11.3 10 5.1 11.3 1.3 1 0 0 1 1 1 0 Tumour-associated protein Endostatin PF06482.11 CDI82158.1 - 9.6 5.6 21.1 12 5.2 21.1 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Lin-8 PF03353.15 CDI82162.1 - 0.0003 20.5 40.1 0.0004 20.1 40.1 1.1 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist Macoilin PF09726.9 CDI82162.1 - 0.025 13.2 33.7 0.043 12.4 33.7 1.4 1 0 0 1 1 1 0 Macoilin family LTV PF04180.14 CDI82162.1 - 0.046 13.4 27.9 0.069 12.9 27.9 1.3 1 0 0 1 1 1 0 Low temperature viability protein Utp14 PF04615.13 CDI82162.1 - 0.11 11.0 36.3 0.13 10.9 36.3 1.1 1 0 0 1 1 1 0 Utp14 protein GREB1 PF15782.5 CDI82162.1 - 0.14 9.2 41.4 0.18 8.9 41.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer BUD22 PF09073.10 CDI82162.1 - 0.38 10.0 38.3 0.53 9.6 38.3 1.1 1 0 0 1 1 1 0 BUD22 TFIIF_alpha PF05793.12 CDI82162.1 - 0.84 8.2 28.1 1.1 7.7 28.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SDA1 PF05285.12 CDI82162.1 - 1.3 8.4 31.5 1.9 7.8 31.5 1.2 1 0 0 1 1 1 0 SDA1 SRP-alpha_N PF04086.13 CDI82162.1 - 8.9 6.1 38.2 16 5.3 38.2 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RR_TM4-6 PF06459.12 CDI82163.1 - 0.0024 17.8 19.3 0.0026 17.6 19.3 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI82163.1 - 0.0048 15.3 32.7 0.0049 15.2 32.7 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 DUF4746 PF15928.5 CDI82163.1 - 0.0049 16.3 9.8 0.0059 16.1 9.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) TFIIA PF03153.13 CDI82163.1 - 0.0055 16.8 55.8 0.0068 16.5 55.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CobT PF06213.12 CDI82163.1 - 0.0059 16.0 31.1 0.0074 15.7 31.1 1.1 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT eIF-3_zeta PF05091.12 CDI82163.1 - 0.009 15.0 20.9 0.0096 14.9 20.9 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Endostatin PF06482.11 CDI82163.1 - 0.011 15.3 19.2 0.012 15.2 19.2 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SID-1_RNA_chan PF13965.6 CDI82163.1 - 0.011 14.1 3.2 0.012 14.1 3.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DDHD PF02862.17 CDI82163.1 - 0.012 15.7 13.8 0.016 15.4 13.8 1.3 1 0 0 1 1 1 0 DDHD domain AF-4 PF05110.13 CDI82163.1 - 0.015 13.5 24.3 0.015 13.4 24.3 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Pox_Ag35 PF03286.14 CDI82163.1 - 0.019 14.8 10.2 0.027 14.3 10.2 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein VIR_N PF15912.5 CDI82163.1 - 0.023 14.3 6.3 0.025 14.2 6.3 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DUF2048 PF09752.9 CDI82163.1 - 0.028 13.5 6.4 0.037 13.1 6.4 1.1 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Neur_chan_memb PF02932.16 CDI82163.1 - 0.031 14.3 14.4 0.036 14.1 14.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SAPS PF04499.15 CDI82163.1 - 0.036 12.9 10.7 0.036 12.9 10.7 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Macoilin PF09726.9 CDI82163.1 - 0.038 12.6 15.1 0.049 12.2 15.1 1.2 1 0 0 1 1 1 0 Macoilin family CLN3 PF02487.17 CDI82163.1 - 0.04 13.0 11.5 0.045 12.8 11.5 1.2 1 0 0 1 1 1 0 CLN3 protein ALMT PF11744.8 CDI82163.1 - 0.05 12.4 14.0 0.058 12.2 14.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter MDM31_MDM32 PF08118.11 CDI82163.1 - 0.054 12.2 11.0 0.078 11.6 11.0 1.3 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins NicO PF03824.16 CDI82163.1 - 0.094 12.0 4.6 0.14 11.4 4.6 1.4 1 0 0 1 1 1 0 High-affinity nickel-transport protein Presenilin PF01080.17 CDI82163.1 - 0.098 11.4 25.6 0.13 11.1 25.6 1.2 1 0 0 1 1 1 0 Presenilin Velvet PF11754.8 CDI82163.1 - 0.1 12.5 16.5 0.13 12.2 16.5 1.3 1 0 0 1 1 1 0 Velvet factor DUF1387 PF07139.11 CDI82163.1 - 0.13 12.0 17.9 0.15 11.8 17.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF4471 PF14740.6 CDI82163.1 - 0.14 11.4 12.4 0.18 11.0 12.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) FAM60A PF15396.6 CDI82163.1 - 0.15 12.1 15.1 0.18 11.8 15.1 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SprA-related PF12118.8 CDI82163.1 - 0.16 11.1 43.8 0.22 10.6 43.8 1.2 1 0 0 1 1 1 0 SprA-related family DUF2828 PF11443.8 CDI82163.1 - 0.17 10.0 17.7 0.19 9.8 17.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Tim54 PF11711.8 CDI82163.1 - 0.18 10.6 17.6 0.25 10.1 17.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CDC45 PF02724.14 CDI82163.1 - 0.22 9.8 16.1 0.25 9.6 16.1 1.1 1 0 0 1 1 1 0 CDC45-like protein SpoIIP PF07454.11 CDI82163.1 - 0.32 10.4 19.6 0.44 10.0 19.6 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF572 PF04502.13 CDI82163.1 - 0.33 10.5 17.9 0.38 10.3 17.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) TMEM43 PF07787.12 CDI82163.1 - 0.39 10.1 12.3 0.62 9.4 12.3 1.3 1 0 0 1 1 1 0 Transmembrane protein 43 Serinc PF03348.15 CDI82163.1 - 0.44 9.4 9.6 0.52 9.2 9.6 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Peroxin-3 PF04882.12 CDI82163.1 - 0.44 9.5 18.8 0.5 9.3 18.8 1.2 1 0 0 1 1 1 0 Peroxin-3 NARP1 PF12569.8 CDI82163.1 - 0.52 9.2 20.4 0.66 8.8 20.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Draxin PF15550.6 CDI82163.1 - 0.52 10.1 16.5 0.68 9.7 16.5 1.2 1 0 0 1 1 1 0 Draxin DUF4045 PF13254.6 CDI82163.1 - 0.57 9.8 22.1 0.67 9.5 22.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF2464 PF10240.9 CDI82163.1 - 0.64 9.5 9.8 0.71 9.4 9.8 1.3 1 0 0 1 1 1 0 Multivesicular body subunit 12 GPCR_chapero_1 PF11904.8 CDI82163.1 - 0.79 9.1 11.6 0.93 8.9 11.6 1.1 1 0 0 1 1 1 0 GPCR-chaperone PPL5 PF18168.1 CDI82163.1 - 0.9 8.8 14.4 1.3 8.3 14.4 1.2 1 0 0 1 1 1 0 Prim-pol family 5 SLC12 PF03522.15 CDI82163.1 - 0.91 8.5 22.1 1.1 8.2 22.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF2347 PF09804.9 CDI82163.1 - 0.92 9.0 11.6 1.1 8.8 11.6 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF2052 PF09747.9 CDI82163.1 - 0.93 9.6 21.1 1.2 9.2 21.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4638 PF15472.6 CDI82163.1 - 1.1 8.9 17.6 1.5 8.5 17.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) GREB1 PF15782.5 CDI82163.1 - 1.2 6.2 23.5 1.3 6.1 23.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Asp-B-Hydro_N PF05279.11 CDI82163.1 - 1.2 9.2 13.4 1.4 8.9 13.4 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region NST1 PF13945.6 CDI82163.1 - 1.3 9.1 27.6 2.2 8.4 27.6 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator Connexin PF00029.19 CDI82163.1 - 1.5 8.6 16.5 2.1 8.0 16.5 1.3 1 0 0 1 1 1 0 Connexin DUF2232 PF09991.9 CDI82163.1 - 1.5 7.9 7.9 8 5.5 7.9 1.9 1 1 0 1 1 1 0 Predicted membrane protein (DUF2232) Cellulose_synt PF03552.14 CDI82163.1 - 1.6 7.1 6.0 1.8 6.9 6.0 1.0 1 0 0 1 1 1 0 Cellulose synthase FAM76 PF16046.5 CDI82163.1 - 1.6 8.0 24.9 2.2 7.6 24.9 1.1 1 0 0 1 1 1 0 FAM76 protein Lin-8 PF03353.15 CDI82163.1 - 1.8 8.1 24.2 2.3 7.7 24.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Peptidase_S49_N PF08496.10 CDI82163.1 - 1.8 8.6 18.5 3.1 7.8 18.5 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal LMBR1 PF04791.16 CDI82163.1 - 2 7.3 10.5 2.1 7.2 10.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Hid1 PF12722.7 CDI82163.1 - 2 6.4 19.3 2.2 6.3 19.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MAJIN PF15077.6 CDI82163.1 - 2.2 8.0 14.1 2.5 7.8 14.1 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Paramyxo_ncap PF00973.19 CDI82163.1 - 2.2 7.1 15.9 2.4 7.0 15.9 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein HCO3_cotransp PF00955.21 CDI82163.1 - 2.2 7.0 7.6 2.6 6.8 7.6 1.1 1 0 0 1 1 1 0 HCO3- transporter family Exonuc_VII_L PF02601.15 CDI82163.1 - 2.3 7.7 29.5 3 7.3 29.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Nop53 PF07767.11 CDI82163.1 - 3.1 7.1 29.8 3.9 6.8 29.8 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) MCM_bind PF09739.9 CDI82163.1 - 4.1 5.7 20.7 5.2 5.4 20.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor YABBY PF04690.13 CDI82163.1 - 4.3 7.9 16.2 6.6 7.3 16.2 1.4 1 0 0 1 1 1 0 YABBY protein V_ATPase_I PF01496.19 CDI82163.1 - 4.4 5.1 27.8 5.4 4.8 27.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MDFI PF15316.6 CDI82163.1 - 5 7.2 12.2 7 6.7 12.2 1.4 1 0 0 1 1 1 0 MyoD family inhibitor Baculo_PP31 PF05311.11 CDI82163.1 - 5.5 6.4 17.8 9.3 5.7 17.8 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Peptidase_U57 PF05582.12 CDI82163.1 - 6.1 6.0 13.7 8.6 5.5 13.7 1.2 1 0 0 1 1 1 0 YabG peptidase U57 CSG2 PF16965.5 CDI82163.1 - 6.6 5.6 12.2 8.3 5.2 12.2 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2126 PF09899.9 CDI82163.1 - 6.8 4.6 15.6 8.8 4.2 15.6 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Otopetrin PF03189.13 CDI82163.1 - 7.2 5.3 15.2 9 5.0 15.2 1.1 1 0 0 1 1 1 0 Otopetrin RIFIN PF02009.16 CDI82163.1 - 7.3 6.4 25.4 9.7 6.0 25.4 1.1 1 0 0 1 1 1 0 Rifin Rrn6 PF10214.9 CDI82163.1 - 7.6 4.9 29.5 9.6 4.6 29.5 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Gti1_Pac2 PF09729.9 CDI82163.1 - 7.8 6.6 21.6 11 6.0 21.6 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family NPR3 PF03666.13 CDI82163.1 - 8.4 5.1 24.1 11 4.7 24.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Med19 PF10278.9 CDI82163.1 - 8.6 6.3 18.3 12 5.8 18.3 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 FapA PF03961.13 CDI82163.1 - 9.4 4.7 12.1 11 4.5 12.1 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A SARAF PF06682.12 CDI82165.1 - 4.8e-05 23.2 24.0 4.8e-05 23.2 24.0 4.2 2 1 2 4 4 4 2 SOCE-associated regulatory factor of calcium homoeostasis Ribosomal_60s PF00428.19 CDI82165.1 - 0.0056 17.2 12.3 0.0056 17.2 12.3 5.4 4 1 1 5 5 5 2 60s Acidic ribosomal protein Spt20 PF12090.8 CDI82165.1 - 0.01 15.5 10.3 0.01 15.5 10.3 5.2 3 2 2 5 5 5 0 Spt20 family SART-1 PF03343.13 CDI82165.1 - 1.6 7.2 49.0 0.85 8.1 16.1 3.1 3 0 0 3 3 3 0 SART-1 family Presenilin PF01080.17 CDI82170.1 - 0.00033 19.5 32.7 0.00033 19.5 32.7 1.5 2 0 0 2 2 2 1 Presenilin Apt1 PF10351.9 CDI82170.1 - 0.004 16.1 14.9 0.0039 16.1 14.9 1.0 1 0 0 1 1 1 1 Golgi-body localisation protein domain DUF3464 PF11947.8 CDI82170.1 - 0.0063 16.3 16.8 0.0063 16.3 16.8 2.6 2 1 1 3 3 2 1 Photosynthesis affected mutant 68 ALMT PF11744.8 CDI82170.1 - 0.08 11.8 26.9 0.11 11.4 26.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 CDI82170.1 - 0.59 8.4 30.9 0.76 8.0 30.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Ndc1_Nup PF09531.10 CDI82170.1 - 0.79 8.3 26.4 0.81 8.3 26.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AAA_11 PF13086.6 CDI82170.1 - 0.88 9.3 30.7 1.2 8.9 30.7 1.3 1 0 0 1 1 1 0 AAA domain Band_3_cyto PF07565.13 CDI82170.1 - 1.8 8.3 34.2 3 7.6 34.2 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Draxin PF15550.6 CDI82170.1 - 2 8.2 24.4 2.6 7.8 24.4 1.2 1 0 0 1 1 1 0 Draxin WTX PF09422.10 CDI82170.1 - 3.2 6.7 24.4 3.7 6.5 24.4 1.1 1 0 0 1 1 1 0 WTX protein Sporozoite_P67 PF05642.11 CDI82170.1 - 4 5.4 22.5 5.3 5.0 22.5 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Caldesmon PF02029.15 CDI82170.1 - 6.4 5.4 36.9 7.2 5.3 36.9 1.1 1 0 0 1 1 1 0 Caldesmon DUF4045 PF13254.6 CDI82170.1 - 6.7 6.2 33.7 7.8 6.0 33.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PAT1 PF09770.9 CDI82170.1 - 8.9 4.4 62.7 10 4.3 62.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 CDI82170.1 - 8.9 6.3 32.1 16 5.5 32.1 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Raftlin PF15250.6 CDI82170.1 - 9.3 4.9 29.4 11 4.7 29.4 1.1 1 0 0 1 1 1 0 Raftlin Peptidase_S49_N PF08496.10 CDI82171.1 - 0.00021 21.4 18.0 0.00025 21.2 18.0 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal Pex24p PF06398.11 CDI82171.1 - 0.00045 19.3 1.6 0.00054 19.1 1.6 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin SID-1_RNA_chan PF13965.6 CDI82171.1 - 0.0013 17.2 10.7 0.0016 17.0 10.7 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 SARAF PF06682.12 CDI82171.1 - 0.0013 18.4 9.6 0.0015 18.3 9.6 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis DUF4131 PF13567.6 CDI82171.1 - 0.0022 17.6 3.2 0.0031 17.2 3.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) Ion_trans PF00520.31 CDI82171.1 - 0.0031 16.8 2.0 0.0034 16.7 2.0 1.1 1 0 0 1 1 1 1 Ion transport protein V_ATPase_I PF01496.19 CDI82171.1 - 0.0042 15.1 19.8 0.0046 14.9 19.8 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CBP_BcsG PF11658.8 CDI82171.1 - 0.0073 14.8 16.8 0.0078 14.7 16.8 1.0 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG Zip PF02535.22 CDI82171.1 - 0.012 14.8 1.2 0.016 14.5 1.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter IgaA PF07095.11 CDI82171.1 - 0.026 12.5 15.0 0.03 12.3 15.0 1.0 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA DUF3487 PF11990.8 CDI82171.1 - 0.028 14.3 10.0 0.037 13.9 10.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3487) PRA1 PF03208.19 CDI82171.1 - 0.03 13.9 2.0 0.037 13.6 2.0 1.2 1 0 0 1 1 1 0 PRA1 family protein Shisa PF13908.6 CDI82171.1 - 0.037 14.3 10.5 0.043 14.1 10.5 1.0 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator CLN3 PF02487.17 CDI82171.1 - 0.06 12.4 16.9 0.063 12.3 16.9 1.0 1 0 0 1 1 1 0 CLN3 protein DUF3810 PF12725.7 CDI82171.1 - 0.065 12.6 11.5 0.069 12.5 11.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) HemY_N PF07219.13 CDI82171.1 - 0.083 13.1 9.8 0.11 12.7 9.8 1.2 1 0 0 1 1 1 0 HemY protein N-terminus DUF5313 PF17240.2 CDI82171.1 - 0.084 13.3 14.9 0.068 13.6 13.8 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5313) CobD_Cbib PF03186.13 CDI82171.1 - 0.13 11.5 1.7 0.13 11.4 1.7 1.1 1 0 0 1 1 1 0 CobD/Cbib protein DUF4013 PF13197.6 CDI82171.1 - 0.14 12.0 7.4 0.15 11.9 7.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4013) SpoIIP PF07454.11 CDI82171.1 - 0.14 11.6 14.1 0.16 11.4 14.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CSG2 PF16965.5 CDI82171.1 - 0.14 11.0 12.4 0.18 10.7 12.4 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Tetraspanin PF00335.20 CDI82171.1 - 0.22 11.2 11.0 0.27 10.9 11.0 1.2 1 0 0 1 1 1 0 Tetraspanin family O-antigen_lig PF13425.6 CDI82171.1 - 0.29 9.9 12.1 0.33 9.7 12.1 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein HemX PF04375.14 CDI82171.1 - 0.34 10.2 42.5 0.41 9.9 42.5 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2828 PF11443.8 CDI82171.1 - 0.45 8.6 15.6 0.49 8.4 15.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF2244 PF10003.9 CDI82171.1 - 0.75 9.5 6.9 1.3 8.7 6.9 1.6 1 1 0 1 1 1 0 Integral membrane protein (DUF2244) DUF4446 PF14584.6 CDI82171.1 - 0.89 9.5 25.1 2.1 8.3 25.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) DUF3646 PF12362.8 CDI82171.1 - 1.1 9.6 15.2 1.8 8.9 15.2 1.3 1 1 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal Neur_chan_memb PF02932.16 CDI82171.1 - 1.1 9.2 18.9 1.4 8.9 18.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sarcoglycan_1 PF04790.13 CDI82171.1 - 1.4 8.2 15.0 1.6 8.0 15.0 1.1 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein Folliculin PF11704.8 CDI82171.1 - 1.7 8.5 16.4 2 8.3 16.4 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport LRR19-TM PF15176.6 CDI82171.1 - 2.1 8.4 6.9 3.8 7.5 6.9 1.6 1 1 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Spore_coat_CotO PF14153.6 CDI82171.1 - 2.7 7.9 26.0 3 7.7 26.0 1.0 1 0 0 1 1 1 0 Spore coat protein CotO G6B PF15096.6 CDI82171.1 - 2.8 7.7 5.7 3.1 7.5 5.7 1.0 1 0 0 1 1 1 0 G6B family FAM176 PF14851.6 CDI82171.1 - 3.6 7.3 16.2 6 6.5 16.2 1.5 1 1 0 1 1 1 0 FAM176 family OATP PF03137.20 CDI82171.1 - 3.9 5.7 15.2 6.4 4.9 15.2 1.4 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family ALMT PF11744.8 CDI82171.1 - 4.3 6.1 16.3 4.7 5.9 16.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DDHD PF02862.17 CDI82171.1 - 5.2 7.2 14.9 6.1 6.9 14.9 1.1 1 0 0 1 1 1 0 DDHD domain PIG-P PF08510.12 CDI82171.1 - 6.5 6.7 7.6 12 5.9 7.6 1.5 1 1 0 1 1 1 0 PIG-P Adaptin_binding PF10199.9 CDI82174.1 - 0.0075 16.9 24.3 0.039 14.5 19.2 3.2 2 1 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 SNF2_N PF00176.23 CDI82174.1 - 0.034 12.9 0.0 0.034 12.9 0.0 3.4 2 2 0 2 2 2 0 SNF2 family N-terminal domain V_ATPase_I PF01496.19 CDI82174.1 - 0.62 7.9 36.1 0.065 11.2 4.9 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family SYF2 PF08231.12 CDI82174.1 - 0.65 10.4 25.5 0.14 12.5 1.8 2.3 2 0 0 2 2 2 0 SYF2 splicing factor CDC45 PF02724.14 CDI82174.1 - 0.7 8.1 28.7 0.1 10.8 17.9 2.2 2 0 0 2 2 2 0 CDC45-like protein SLC12 PF03522.15 CDI82174.1 - 1 8.3 29.4 0.14 11.1 18.9 2.2 2 0 0 2 2 2 0 Solute carrier family 12 GPCR_chapero_1 PF11904.8 CDI82174.1 - 1.3 8.4 18.6 0.62 9.5 11.2 2.3 2 0 0 2 2 2 0 GPCR-chaperone Vfa1 PF08432.10 CDI82174.1 - 4.1 7.7 37.6 3.1 8.1 3.3 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Pkinase_fungal PF17667.1 CDI82174.1 - 7.4 5.2 19.8 3.6 6.3 12.6 2.4 2 0 0 2 2 2 0 Fungal protein kinase Sin_N PF04801.13 CDI82174.1 - 9.4 5.3 43.6 0.34 10.1 27.1 2.5 2 0 0 2 2 2 0 Sin-like protein conserved region RskA PF10099.9 CDI82176.1 - 0.0021 18.4 15.1 0.0021 18.4 15.1 4.7 3 1 0 3 3 3 2 Anti-sigma-K factor rskA Rxt3 PF08642.10 CDI82176.1 - 0.74 10.6 0.0 0.74 10.6 0.0 5.7 3 1 2 5 5 5 0 Histone deacetylation protein Rxt3 Peptidase_S15 PF02129.18 CDI82176.1 - 9.2 5.8 0.0 9.2 5.8 0.0 5.9 2 2 2 4 4 4 0 X-Pro dipeptidyl-peptidase (S15 family) Aquarius_N PF16399.5 CDI82180.1 - 3.4e-05 22.1 0.0 3.4e-05 22.1 0.0 3.8 3 1 1 4 4 2 1 Intron-binding protein aquarius N-terminus RskA PF10099.9 CDI82180.1 - 0.00014 22.3 13.4 0.00014 22.3 13.4 3.9 2 1 1 3 3 2 1 Anti-sigma-K factor rskA DUF1180 PF06679.12 CDI82180.1 - 0.012 16.1 2.0 0.012 16.1 2.0 3.9 2 2 1 3 3 2 0 Protein of unknown function (DUF1180) Afi1 PF07792.12 CDI82180.1 - 0.025 15.1 0.7 0.025 15.1 0.7 3.3 2 1 1 3 3 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4834 PF16118.5 CDI82180.1 - 0.038 15.0 2.8 0.038 15.0 2.8 4.5 2 1 1 3 3 2 0 Domain of unknown function (DUF4834) Lin-8 PF03353.15 CDI82180.1 - 0.089 12.3 51.6 0.25 10.8 42.1 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Borrelia_P83 PF05262.11 CDI82180.1 - 0.23 9.9 39.5 0.0071 14.9 26.6 2.1 2 0 0 2 2 2 0 Borrelia P83/100 protein BUD22 PF09073.10 CDI82180.1 - 0.26 10.6 47.3 2.6 7.3 42.5 2.1 2 0 0 2 2 2 0 BUD22 DUF572 PF04502.13 CDI82180.1 - 0.43 10.2 41.6 1.1 8.8 0.6 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF572) Sin_N PF04801.13 CDI82180.1 - 0.43 9.7 58.1 1.5 7.9 46.4 2.3 2 0 0 2 2 2 0 Sin-like protein conserved region DUF4813 PF16072.5 CDI82180.1 - 2.3 7.8 10.7 4.7 6.8 10.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) SPX PF03105.19 CDI82180.1 - 3.8 7.3 43.9 3.2 7.6 37.1 2.4 2 0 0 2 2 2 0 SPX domain DUF1772 PF08592.11 CDI82180.1 - 6.6 7.0 11.0 33 4.8 11.0 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) Trp_oprn_chp PF09534.10 CDI82182.1 - 0.0019 18.1 3.5 0.0021 17.9 3.5 1.1 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Sulf_transp PF04143.14 CDI82182.1 - 0.39 10.2 1.3 0.41 10.2 1.3 1.1 1 0 0 1 1 1 0 Sulphur transport DUF2681 PF10883.8 CDI82182.1 - 1 9.8 34.8 1.1 9.7 5.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Zip PF02535.22 CDI82182.1 - 2.4 7.3 4.8 2.7 7.1 4.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2126 PF09899.9 CDI82182.1 - 3 5.8 10.7 3.4 5.6 10.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) PIP5K PF01504.18 CDI82182.1 - 4 6.6 11.6 5.7 6.1 11.6 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase INSIG PF07281.12 CDI82182.1 - 4.4 6.9 7.0 5.8 6.5 7.0 1.1 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) Senescence_reg PF04520.13 CDI82182.1 - 5 7.9 14.2 6.4 7.6 14.2 1.2 1 0 0 1 1 1 0 Senescence regulator Presenilin PF01080.17 CDI82182.1 - 5.7 5.6 21.0 6.7 5.4 21.0 1.1 1 0 0 1 1 1 0 Presenilin XRN_M PF17846.1 CDI82182.1 - 6.2 5.6 15.0 7.5 5.4 15.0 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Neur_chan_memb PF02932.16 CDI82182.1 - 6.3 6.8 14.0 7.5 6.5 14.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AP1AR PF15745.5 CDI82182.1 - 6.3 6.3 17.0 7.9 6.0 17.0 1.1 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein V_ATPase_I PF01496.19 CDI82182.1 - 6.7 4.5 18.8 7.6 4.3 18.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RskA PF10099.9 CDI82182.1 - 6.8 6.9 29.3 1.4e+02 2.6 5.8 2.0 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Het-C PF07217.11 CDI82182.1 - 9.5 4.6 12.3 10 4.5 12.3 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C CLN3 PF02487.17 CDI82182.1 - 9.9 5.1 12.3 12 4.8 12.3 1.2 1 0 0 1 1 1 0 CLN3 protein Utp14 PF04615.13 CDI82183.1 - 3.1e-07 29.4 6.0 3.1e-07 29.4 6.0 4.2 3 1 1 4 4 4 2 Utp14 protein BUD22 PF09073.10 CDI82183.1 - 0.00013 21.5 9.0 0.00013 21.5 9.0 4.9 3 1 0 4 4 4 2 BUD22 SARAF PF06682.12 CDI82183.1 - 0.00062 19.5 17.2 0.00062 19.5 17.2 6.3 4 2 1 5 5 5 2 SOCE-associated regulatory factor of calcium homoeostasis Adaptin_binding PF10199.9 CDI82183.1 - 0.076 13.6 0.0 0.076 13.6 0.0 8.0 4 4 0 4 4 4 0 Alpha and gamma adaptin binding protein p34 CbiD PF01888.17 CDI82184.1 - 0.05 12.9 2.2 0.075 12.3 2.2 1.4 1 0 0 1 1 1 0 CbiD AMP-binding PF00501.28 CDI82184.1 - 1.1 7.8 6.2 1.7 7.2 6.2 1.3 1 0 0 1 1 1 0 AMP-binding enzyme DcuA_DcuB PF03605.14 CDI82184.1 - 1.2 7.9 4.5 1.9 7.3 4.5 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter NAM-associated PF14303.6 CDI82185.1 - 3.7e-05 24.5 2.2 3.7e-05 24.5 2.2 9.3 4 4 3 7 7 7 1 No apical meristem-associated C-terminal domain CNDH2_C PF16858.5 CDI82185.1 - 0.0032 17.4 2.6 0.0032 17.4 2.6 6.3 5 1 0 6 6 6 3 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF4834 PF16118.5 CDI82185.1 - 0.004 18.1 6.6 0.004 18.1 6.6 10.3 9 2 1 10 10 10 1 Domain of unknown function (DUF4834) rRNA_processing PF08524.11 CDI82185.1 - 0.0064 16.5 5.9 0.0064 16.5 5.9 7.8 5 2 1 7 7 7 1 rRNA processing RR_TM4-6 PF06459.12 CDI82185.1 - 0.0086 15.9 1.0 0.0086 15.9 1.0 7.0 4 2 0 6 6 6 1 Ryanodine Receptor TM 4-6 Orf78 PF06024.12 CDI82185.1 - 0.0093 16.3 4.2 0.0093 16.3 4.2 8.5 7 1 0 7 7 7 1 Orf78 (ac78) TAS2R PF05296.13 CDI82185.1 - 0.084 12.0 0.5 0.18 10.9 0.5 1.5 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) Pkinase PF00069.25 CDI82186.1 - 1.3e-17 64.0 0.0 1.6e-09 37.5 0.0 6.3 6 1 0 7 7 7 2 Protein kinase domain DUF2828 PF11443.8 CDI82186.1 - 0.00027 19.2 11.6 0.00027 19.2 11.6 5.8 4 1 1 5 5 5 2 Domain of unknown function (DUF2828) Nha1_C PF08619.10 CDI82186.1 - 0.0023 17.2 4.7 0.0023 17.2 4.7 6.5 2 1 4 6 6 6 1 Alkali metal cation/H+ antiporter Nha1 C terminus SR-25 PF10500.9 CDI82186.1 - 0.013 15.1 0.8 0.013 15.1 0.8 7.5 6 1 1 7 7 7 0 Nuclear RNA-splicing-associated protein Sox_N PF12444.8 CDI82188.1 - 6.8 7.9 11.3 8.5 7.6 11.3 1.2 1 0 0 1 1 1 0 Sox developmental protein N terminal eIF-3_zeta PF05091.12 CDI82191.1 - 0.98 8.3 24.4 1.5 7.7 24.4 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FHIPEP PF00771.20 CDI82191.1 - 1.5 7.2 8.3 3.4 6.0 8.3 1.6 1 0 0 1 1 1 0 FHIPEP family DUF2232 PF09991.9 CDI82191.1 - 4.1 6.5 4.9 10 5.2 4.9 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) MMM1 PF10296.9 CDI82201.1 - 1.9 7.5 12.5 1.9 7.5 12.5 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Tfb4 PF03850.14 CDI82201.1 - 2 7.9 14.3 2 7.8 14.3 1.0 1 0 0 1 1 1 0 Transcription factor Tfb4 AIF_C PF14721.6 CDI82201.1 - 2.4 8.5 16.1 2.6 8.4 16.1 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term AIM3 PF17096.5 CDI82201.1 - 3.3 8.7 15.6 5.6 8.0 15.6 1.4 1 1 0 1 1 1 0 Altered inheritance of mitochondria protein 3 Serinc PF03348.15 CDI82201.1 - 3.6 6.4 13.2 3.4 6.5 13.2 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2828 PF11443.8 CDI82201.1 - 4.2 5.3 21.2 4.1 5.4 21.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Peroxin-13_N PF04088.13 CDI82201.1 - 4.6 7.5 12.2 5.5 7.3 12.2 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF2072 PF09845.9 CDI82201.1 - 4.9 7.4 18.7 5.3 7.3 18.7 1.0 1 0 0 1 1 1 0 Zn-ribbon containing protein CLN3 PF02487.17 CDI82201.1 - 4.9 6.1 16.6 4.6 6.2 16.6 1.0 1 0 0 1 1 1 0 CLN3 protein CSG2 PF16965.5 CDI82201.1 - 5.4 5.8 13.7 5.2 5.9 13.7 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Auxin_canalis PF05703.11 CDI82201.1 - 7.7 6.4 12.1 8.7 6.2 12.1 1.0 1 0 0 1 1 1 0 Auxin canalisation OATP PF03137.20 CDI82201.1 - 7.9 4.6 11.8 7.3 4.8 11.8 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Tim54 PF11711.8 CDI82201.1 - 9.6 4.9 19.5 9.7 4.9 19.5 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 G0-G1_switch_2 PF15103.6 CDI82201.1 - 9.6 6.7 14.7 13 6.3 14.7 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 PIP5K PF01504.18 CDI82201.1 - 9.7 5.3 19.0 9.4 5.4 19.0 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase EPL1 PF10513.9 CDI82201.1 - 9.8 6.5 25.5 11 6.4 25.5 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like MAPEG PF01124.18 CDI82209.1 - 0.00038 20.4 1.5 0.002 18.1 0.0 2.8 2 0 0 2 2 2 1 MAPEG family DUF4667 PF15700.5 CDI82209.1 - 0.0049 17.0 2.3 0.0049 17.0 2.3 6.6 5 2 0 5 5 5 1 Domain of unknown function (DUF4667) SPX PF03105.19 CDI82209.1 - 0.07 13.0 60.3 1.8e+04 -21.4 58.7 4.2 1 1 0 1 1 1 0 SPX domain DUF3464 PF11947.8 CDI82209.1 - 0.21 11.3 0.0 0.21 11.3 0.0 6.1 5 1 0 5 5 5 0 Photosynthesis affected mutant 68 RIC3 PF15361.6 CDI82209.1 - 4.6 7.6 0.0 4.6 7.6 0.0 6.0 6 0 0 6 6 6 0 Resistance to inhibitors of cholinesterase homologue 3 SPX PF03105.19 CDI82215.1 - 0.0069 16.4 9.9 0.0069 16.4 9.9 3.9 3 1 1 4 4 4 1 SPX domain DUF775 PF05603.12 CDI82215.1 - 0.0074 15.8 1.3 0.0074 15.8 1.3 3.9 4 0 0 4 4 4 1 Protein of unknown function (DUF775) SUIM_assoc PF16619.5 CDI82215.1 - 0.0082 16.2 5.0 0.0082 16.2 5.0 3.8 3 0 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 SR-25 PF10500.9 CDI82215.1 - 0.013 15.2 7.7 0.013 15.2 7.7 5.6 5 1 0 5 5 5 0 Nuclear RNA-splicing-associated protein CWC25 PF12542.8 CDI82215.1 - 0.065 14.1 1.1 0.065 14.1 1.1 4.8 4 1 0 4 4 4 0 Pre-mRNA splicing factor Utp14 PF04615.13 CDI82215.1 - 5.8 5.3 37.4 0.54 8.8 7.8 3.1 3 0 0 3 3 3 0 Utp14 protein Peptidase_A22B PF04258.13 CDI82216.1 - 1e-50 172.9 19.7 1.7e-44 152.4 13.3 2.6 1 1 1 2 2 2 2 Signal peptide peptidase RT_RNaseH PF17917.1 CDI82217.1 - 1.2e-22 80.2 0.0 3.2e-22 78.8 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDI82217.1 - 1.2e-22 79.8 0.0 3e-22 78.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDI82217.1 - 6.7e-11 42.1 0.1 1.8e-10 40.8 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDI82217.1 - 1.3e-08 34.6 0.0 3e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-CCHC PF00098.23 CDI82217.1 - 0.0039 17.2 3.6 0.011 15.8 3.6 1.8 1 0 0 1 1 1 1 Zinc knuckle Kelch_5 PF13854.6 CDI82218.1 - 2.4e-09 37.0 0.0 2.3e-05 24.2 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 CDI82218.1 - 3.9e-07 30.0 0.0 0.0012 18.8 0.0 2.8 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.6 CDI82218.1 - 0.00033 20.8 12.4 1.1 9.7 0.0 5.3 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.6 CDI82218.1 - 0.0012 19.1 0.0 0.084 13.2 0.0 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 CDI82218.1 - 0.038 13.6 0.0 1.6 8.4 0.0 3.3 2 0 0 2 2 2 0 Kelch motif UPF0203 PF05254.12 CDI82219.1 - 2.9e-08 33.8 1.0 0.0094 16.2 0.0 2.3 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0203) Tmemb_cc2 PF10267.9 CDI82219.1 - 0.038 13.2 2.3 0.047 12.8 2.3 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Thioredoxin_8 PF13905.6 CDI82220.1 - 2.3e-20 72.7 0.0 3.5e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 CDI82220.1 - 3.7e-08 33.8 0.0 8e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 CDI82220.1 - 2.7e-05 24.1 0.0 0.00014 21.7 0.0 2.0 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin PF00085.20 CDI82220.1 - 0.0021 18.0 0.0 0.039 13.9 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_7 PF13899.6 CDI82220.1 - 0.0076 16.4 0.1 0.02 15.1 0.1 1.7 1 0 0 1 1 1 1 Thioredoxin-like TFIIA PF03153.13 CDI82225.1 - 0.023 14.7 24.3 0.033 14.2 24.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AF-4 PF05110.13 CDI82225.1 - 0.05 11.7 14.3 0.083 11.0 14.3 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein LMBR1 PF04791.16 CDI82225.1 - 0.48 9.3 2.5 0.68 8.8 2.5 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein SID-1_RNA_chan PF13965.6 CDI82225.1 - 1.6 7.0 5.3 2.5 6.4 5.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PAT1 PF09770.9 CDI82225.1 - 7.4 4.7 23.1 9.8 4.3 23.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CCSAP PF15748.5 CDI82225.1 - 8.1 6.5 15.1 15 5.7 15.1 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF3040 PF11239.8 CDI82227.1 - 0.057 13.7 0.5 1.4 9.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) SARAF PF06682.12 CDI82227.1 - 0.07 12.8 2.2 0.11 12.1 0.0 1.9 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Snapin_Pallidin PF14712.6 CDI82227.1 - 0.1 13.0 1.5 4 7.9 0.1 2.7 2 0 0 2 2 2 0 Snapin/Pallidin zf_ZIC PF18366.1 CDI82227.1 - 0.14 12.3 0.3 0.41 10.8 0.0 1.9 2 0 0 2 2 2 0 Zic proteins zinc finger domain CDC45 PF02724.14 CDI82227.1 - 0.22 9.8 5.1 0.35 9.1 5.1 1.3 1 0 0 1 1 1 0 CDC45-like protein Nop53 PF07767.11 CDI82227.1 - 1.2 8.4 19.0 0.028 13.8 11.6 1.8 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Met_10 PF02475.16 CDI82228.1 - 5.7e-47 160.0 0.0 6.6e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 CDI82228.1 - 0.00011 21.6 0.1 0.00018 20.8 0.1 1.3 1 1 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_15 PF09445.10 CDI82228.1 - 0.0038 16.8 0.0 0.0058 16.2 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 CDI82228.1 - 0.0056 17.4 0.1 0.013 16.2 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDI82228.1 - 0.0066 16.1 0.1 0.011 15.4 0.1 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 SAM_MT PF04445.13 CDI82228.1 - 0.013 14.9 0.2 0.026 13.9 0.2 1.4 1 1 0 1 1 1 0 Putative SAM-dependent methyltransferase Tricho_coat PF05892.11 CDI82228.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Trichovirus coat protein NPR3 PF03666.13 CDI82229.1 - 0.06 12.1 13.7 0.073 11.8 13.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC27 PF09507.10 CDI82229.1 - 0.12 11.7 24.7 0.16 11.3 24.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF4746 PF15928.5 CDI82229.1 - 0.15 11.5 12.5 0.21 11.0 12.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SAPS PF04499.15 CDI82229.1 - 0.15 10.8 11.6 0.17 10.6 11.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4551 PF15087.6 CDI82229.1 - 0.19 10.5 12.7 0.23 10.2 12.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SLC12 PF03522.15 CDI82229.1 - 0.24 10.4 13.4 0.26 10.2 13.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF5023 PF16426.5 CDI82229.1 - 0.26 10.9 1.2 0.38 10.4 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5023) Paf1 PF03985.13 CDI82229.1 - 0.36 9.8 20.1 0.45 9.5 20.1 1.2 1 0 0 1 1 1 0 Paf1 Presenilin PF01080.17 CDI82229.1 - 0.42 9.3 20.5 0.59 8.8 20.5 1.2 1 0 0 1 1 1 0 Presenilin DUF853 PF05872.12 CDI82229.1 - 0.45 9.0 10.6 0.58 8.7 10.6 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) FancD2 PF14631.6 CDI82229.1 - 0.55 7.6 14.3 0.68 7.3 14.3 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Endostatin PF06482.11 CDI82229.1 - 0.79 9.1 11.2 0.97 8.8 11.2 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Hid1 PF12722.7 CDI82229.1 - 1.4 6.9 14.8 1.7 6.7 14.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PA26 PF04636.13 CDI82229.1 - 2.3 7.1 10.1 2.5 6.9 10.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) ALMT PF11744.8 CDI82229.1 - 2.9 6.6 13.2 3.4 6.4 13.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 CDI82229.1 - 4.2 5.5 16.5 5.4 5.2 16.5 1.1 1 0 0 1 1 1 0 CDC45-like protein XRN_M PF17846.1 CDI82229.1 - 4.7 6.0 13.3 5.7 5.8 13.3 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Membralin PF09746.9 CDI82229.1 - 6.4 5.7 9.4 7.9 5.4 9.4 1.1 1 0 0 1 1 1 0 Tumour-associated protein Zip PF02535.22 CDI82229.1 - 7.7 5.6 12.9 10 5.2 12.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SKA1 PF07160.12 CDI82229.1 - 9.1 6.1 19.5 14 5.5 19.5 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 CobT PF06213.12 CDI82229.1 - 9.6 5.5 24.4 22 4.3 24.4 1.6 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TFIIA PF03153.13 CDI82250.1 - 0.00018 21.6 42.2 0.028 14.4 14.7 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DUF4148 PF13663.6 CDI82250.1 - 0.028 14.6 34.0 0.17 12.1 0.9 5.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4148) SPX PF03105.19 CDI82250.1 - 0.065 13.1 24.3 0.11 12.5 1.8 2.1 2 0 0 2 2 2 0 SPX domain GREB1 PF15782.5 CDI82250.1 - 0.41 7.7 31.4 0.012 12.8 6.3 2.0 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer PRIMA1 PF16101.5 CDI82250.1 - 0.46 10.5 5.3 0.23 11.5 2.2 2.2 1 1 1 2 2 2 0 Proline-rich membrane anchor 1 Activator_LAG-3 PF11498.8 CDI82250.1 - 1.1 8.2 44.5 0.42 9.5 17.6 2.3 2 0 0 2 2 2 0 Transcriptional activator LAG-3 EPL1 PF10513.9 CDI82250.1 - 4.5 7.6 15.8 0.13 12.7 0.2 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like Med15 PF09606.10 CDI82250.1 - 4.8 5.7 36.6 0.22 10.1 12.8 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Peptidase_S15 PF02129.18 CDI82250.1 - 6.7 6.2 12.4 1 8.9 3.0 2.3 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Macoilin PF09726.9 CDI82250.1 - 7.9 4.9 33.7 0.36 9.3 16.7 2.9 3 0 0 3 3 3 0 Macoilin family DUF1645 PF07816.11 CDI82250.1 - 9.1 6.8 37.3 0.035 14.7 13.7 3.2 2 1 0 2 2 1 0 Protein of unknown function (DUF1645) RskA PF10099.9 CDI82255.1 - 0.011 16.0 2.5 0.011 16.0 2.5 6.8 1 1 3 5 5 5 0 Anti-sigma-K factor rskA Otopetrin PF03189.13 CDI82259.1 - 0.016 14.0 3.9 0.02 13.8 3.9 1.2 1 0 0 1 1 1 0 Otopetrin Presenilin PF01080.17 CDI82259.1 - 0.022 13.6 29.7 0.038 12.8 29.7 1.4 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 CDI82259.1 - 0.022 14.0 11.4 0.029 13.6 11.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter MDM10 PF12519.8 CDI82259.1 - 0.043 12.7 17.3 0.063 12.1 17.3 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Caldesmon PF02029.15 CDI82259.1 - 0.088 11.6 27.0 0.12 11.1 27.0 1.1 1 0 0 1 1 1 0 Caldesmon CNDH2_C PF16858.5 CDI82259.1 - 0.22 11.3 25.3 0.37 10.6 25.3 1.4 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Mem_trans PF03547.18 CDI82259.1 - 0.48 8.8 1.4 0.63 8.4 1.4 1.3 1 0 0 1 1 1 0 Membrane transport protein Nop14 PF04147.12 CDI82259.1 - 0.54 8.4 24.8 0.72 8.0 24.8 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2151 PF10221.9 CDI82259.1 - 0.86 8.1 13.9 1.2 7.7 13.9 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator DUF4407 PF14362.6 CDI82259.1 - 1.9 7.8 29.5 0.098 12.0 21.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) FAM76 PF16046.5 CDI82259.1 - 2 7.7 28.3 3.1 7.1 28.3 1.2 1 0 0 1 1 1 0 FAM76 protein DUF4045 PF13254.6 CDI82259.1 - 4.1 7.0 32.6 0.11 12.1 19.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) CDC45 PF02724.14 CDI82259.1 - 4.3 5.5 29.9 5.9 5.1 29.9 1.1 1 0 0 1 1 1 0 CDC45-like protein HC2 PF07382.11 CDI82260.1 - 0.15 12.1 69.6 1.7 8.7 35.5 2.2 1 1 1 2 2 2 0 Histone H1-like nucleoprotein HC2 RskA PF10099.9 CDI82264.1 - 0.0011 19.3 2.5 0.0011 19.3 2.5 3.1 2 1 0 2 2 2 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI82264.1 - 0.0011 18.6 18.5 0.0011 18.6 18.5 3.5 2 1 1 3 3 3 1 Spt20 family DUF3446 PF11928.8 CDI82264.1 - 0.029 14.6 8.8 0.029 14.6 8.8 6.0 4 2 0 4 4 4 0 Early growth response N-terminal domain DUF5320 PF17253.2 CDI82264.1 - 3.7 8.7 17.0 0.18 12.9 6.0 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5320) FHIPEP PF00771.20 CDI82264.1 - 5.9 5.2 10.5 0.073 11.5 0.4 2.1 2 0 0 2 2 2 0 FHIPEP family DUF572 PF04502.13 CDI82264.1 - 7.4 6.1 43.3 0.021 14.5 23.5 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF572) RskA PF10099.9 CDI82265.1 - 1.4e-09 38.5 5.2 1.4e-09 38.5 5.2 2.3 1 1 1 2 2 2 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI82265.1 - 0.027 14.5 38.5 0.035 14.1 38.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI82265.1 - 0.17 11.4 37.2 0.076 12.6 31.5 2.2 2 0 0 2 2 2 0 Spt20 family Eaf7 PF07904.13 CDI82265.1 - 0.93 9.9 6.3 2.4 8.6 6.3 1.7 1 0 0 1 1 1 0 Chromatin modification-related protein EAF7 EOS1 PF12326.8 CDI82265.1 - 4.2 7.3 4.5 5.5 6.9 4.4 1.4 1 1 0 1 1 1 0 N-glycosylation protein zf-C3HC4 PF00097.25 CDI82268.1 - 0.08 12.8 0.5 0.17 11.8 0.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) LSM PF01423.22 CDI82270.1 - 6e-16 57.9 0.2 8.9e-16 57.3 0.2 1.3 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CDI82270.1 - 0.015 15.0 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 Hfq protein SPC22 PF04573.12 CDI82271.1 - 4.5e-41 140.2 0.0 5.6e-41 139.9 0.0 1.1 1 0 0 1 1 1 1 Signal peptidase subunit MlaA PF04333.13 CDI82271.1 - 0.027 14.2 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 MlaA lipoprotein PgaPase_1 PF06162.12 CDI82271.1 - 0.028 14.2 0.3 0.24 11.2 0.1 1.9 1 1 0 2 2 2 0 Putative pyroglutamyl peptidase PgaPase_1 His_Phos_1 PF00300.22 CDI82272.1 - 0.011 15.4 0.1 11 5.7 0.0 3.1 2 1 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) CDC45 PF02724.14 CDI82280.1 - 0.00055 18.4 24.0 0.00065 18.1 24.0 1.1 1 0 0 1 1 1 1 CDC45-like protein Kei1 PF08552.11 CDI82280.1 - 0.0017 18.2 8.3 0.0017 18.2 8.3 2.5 1 1 1 2 2 1 1 Inositolphosphorylceramide synthase subunit Kei1 FAM60A PF15396.6 CDI82280.1 - 0.0061 16.6 23.6 0.0084 16.1 23.6 1.3 1 0 0 1 1 1 1 Protein Family FAM60A Paramyxo_ncap PF00973.19 CDI82280.1 - 0.0068 15.4 22.9 0.009 15.0 22.9 1.2 1 0 0 1 1 1 1 Paramyxovirus nucleocapsid protein PMSI1 PF15322.6 CDI82280.1 - 0.03 13.8 19.2 0.04 13.4 19.2 1.2 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Hid1 PF12722.7 CDI82280.1 - 0.03 12.5 29.5 0.032 12.4 29.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PAT1 PF09770.9 CDI82280.1 - 0.034 12.4 55.1 0.039 12.2 55.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LAP1C PF05609.12 CDI82280.1 - 0.043 12.9 30.3 0.052 12.7 30.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GREB1 PF15782.5 CDI82280.1 - 0.066 10.3 32.2 0.073 10.2 32.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Raftlin PF15250.6 CDI82280.1 - 0.079 11.7 27.7 0.094 11.4 27.7 1.0 1 0 0 1 1 1 0 Raftlin Macoilin PF09726.9 CDI82280.1 - 0.1 11.2 26.0 0.13 10.8 26.0 1.2 1 0 0 1 1 1 0 Macoilin family GAGA_bind PF06217.12 CDI82280.1 - 0.2 11.9 26.8 0.24 11.7 26.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF572 PF04502.13 CDI82280.1 - 0.21 11.2 27.7 0.24 11.0 27.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4045 PF13254.6 CDI82280.1 - 0.21 11.2 29.7 0.23 11.0 29.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) AAA_11 PF13086.6 CDI82280.1 - 0.22 11.3 31.0 0.27 11.0 31.0 1.2 1 0 0 1 1 1 0 AAA domain RIFIN PF02009.16 CDI82280.1 - 0.24 11.3 26.6 0.3 10.9 26.6 1.0 1 0 0 1 1 1 0 Rifin Dapper PF15268.6 CDI82280.1 - 0.26 10.1 35.9 0.28 10.0 35.9 1.0 1 0 0 1 1 1 0 Dapper RR_TM4-6 PF06459.12 CDI82280.1 - 0.28 11.0 36.9 0.43 10.4 36.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hamartin PF04388.12 CDI82280.1 - 0.4 9.3 30.2 0.44 9.2 30.2 1.0 1 0 0 1 1 1 0 Hamartin protein MAP7 PF05672.11 CDI82280.1 - 0.6 9.8 54.8 0.82 9.3 54.8 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family SAGA-Tad1 PF12767.7 CDI82280.1 - 0.65 9.7 27.2 0.76 9.5 27.2 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit PA26 PF04636.13 CDI82280.1 - 0.69 8.8 24.3 0.86 8.4 24.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CDC27 PF09507.10 CDI82280.1 - 1.5 8.1 35.7 1.9 7.8 35.7 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CCSAP PF15748.5 CDI82280.1 - 1.9 8.6 43.6 3.2 7.9 43.6 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Vac7 PF12751.7 CDI82280.1 - 2 7.7 22.0 2.4 7.5 22.0 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 FapA PF03961.13 CDI82280.1 - 2.7 6.5 17.2 3.3 6.2 17.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A MCM_bind PF09739.9 CDI82280.1 - 2.9 6.2 30.8 4.2 5.7 30.8 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CAC1F_C PF16885.5 CDI82280.1 - 3.3 7.3 24.2 4 7.0 24.2 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term O-antigen_lig PF13425.6 CDI82280.1 - 3.6 6.3 15.6 5.7 5.6 15.6 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Presenilin PF01080.17 CDI82280.1 - 4.4 6.0 49.5 6.9 5.3 49.5 1.2 1 0 0 1 1 1 0 Presenilin WTX PF09422.10 CDI82280.1 - 4.9 6.1 24.4 5.5 5.9 24.4 1.1 1 0 0 1 1 1 0 WTX protein Miga PF10265.9 CDI82280.1 - 5.5 5.9 19.7 8 5.3 19.7 1.2 1 0 0 1 1 1 0 Mitoguardin GPCR_chapero_1 PF11904.8 CDI82280.1 - 5.6 6.3 23.1 6.6 6.1 23.1 1.2 1 0 0 1 1 1 0 GPCR-chaperone PPP4R2 PF09184.11 CDI82280.1 - 6.1 6.4 21.1 9.6 5.7 21.1 1.3 1 0 0 1 1 1 0 PPP4R2 SLC12 PF03522.15 CDI82280.1 - 6.9 5.6 42.8 9 5.2 42.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 CDI82280.1 - 7.6 5.2 31.0 11 4.7 31.0 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter CDK5_activator PF03261.15 CDI82280.1 - 8.5 5.8 31.1 11 5.5 31.1 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Apt1 PF10351.9 CDI82280.1 - 8.6 5.1 26.3 11 4.8 26.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain AF-4 PF05110.13 CDI82280.1 - 8.7 4.3 45.8 11 3.9 45.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SAPS PF04499.15 CDI82280.1 - 9.8 4.8 29.3 14 4.3 29.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Sec62 PF03839.16 CDI82280.1 - 10 5.6 32.9 16 4.9 32.9 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 RskA PF10099.9 CDI82289.1 - 0.00033 21.0 0.0 0.00033 21.0 0.0 7.3 1 1 1 2 2 2 1 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI82289.1 - 0.036 15.0 26.0 0.036 15.0 26.0 9.6 2 2 5 7 7 7 0 Domain of unknown function (DUF4834) SR-25 PF10500.9 CDI82292.1 - 0.11 12.1 59.6 0.71 9.4 54.3 2.8 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Pheromone PF08015.11 CDI82292.1 - 0.42 11.7 15.6 0.21 12.6 8.3 2.6 2 0 0 2 2 2 0 Fungal mating-type pheromone SSP160 PF06933.11 CDI82292.1 - 2.6 6.1 12.8 3.5 5.7 12.8 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PmbA_TldD PF01523.16 CDI82292.1 - 9.6 5.9 12.1 11 5.7 12.1 1.2 1 0 0 1 1 1 0 Putative modulator of DNA gyrase Spt20 PF12090.8 CDI82293.1 - 3.2e-05 23.7 11.8 3.8e-05 23.4 11.8 1.1 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI82293.1 - 0.00046 19.3 6.3 0.00052 19.1 6.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI82293.1 - 0.034 14.2 15.7 0.046 13.7 15.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4064 PF13273.6 CDI82293.1 - 0.22 11.8 3.1 0.25 11.6 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) ANAPC_CDC26 PF10471.9 CDI82293.1 - 0.84 10.5 20.8 0.1 13.4 14.1 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Orf78 PF06024.12 CDI82293.1 - 0.95 9.8 2.6 0.7 10.2 0.7 1.7 2 0 0 2 2 2 0 Orf78 (ac78) TMEM51 PF15345.6 CDI82293.1 - 1 9.1 8.8 1.5 8.6 8.8 1.3 1 1 0 1 1 1 0 Transmembrane protein 51 DUF3464 PF11947.8 CDI82293.1 - 4.5 7.0 7.9 6.7 6.4 7.6 1.5 1 1 0 1 1 1 0 Photosynthesis affected mutant 68 DREPP PF05558.12 CDI82296.1 - 7.9 6.3 9.4 8.3 6.2 9.4 1.0 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide SelP_N PF04592.14 CDI82296.1 - 9.5 5.6 28.2 9.7 5.5 28.2 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CCDC53 PF10152.9 CDI82302.1 - 0.0028 18.1 5.1 0.0033 17.8 5.1 1.1 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex Peptidase_S49_N PF08496.10 CDI82302.1 - 0.0044 17.1 4.4 0.0048 17.0 4.4 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal Orf78 PF06024.12 CDI82302.1 - 0.0071 16.6 8.5 0.11 12.8 2.9 2.1 1 1 1 2 2 2 1 Orf78 (ac78) Connexin PF00029.19 CDI82302.1 - 0.012 15.4 1.3 0.014 15.1 1.3 1.2 1 0 0 1 1 1 0 Connexin TFB6 PF17110.5 CDI82302.1 - 0.015 15.0 0.2 0.022 14.5 0.2 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF4175 PF13779.6 CDI82302.1 - 0.017 13.0 22.8 0.019 12.9 22.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4050 PF13259.6 CDI82302.1 - 0.027 14.8 4.1 0.032 14.5 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Spore_coat_CotO PF14153.6 CDI82302.1 - 0.041 13.8 13.7 0.056 13.4 13.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DUF2828 PF11443.8 CDI82302.1 - 0.049 11.7 4.1 0.052 11.6 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DDHD PF02862.17 CDI82302.1 - 0.071 13.3 4.6 0.088 13.0 4.6 1.1 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 CDI82302.1 - 0.073 13.1 3.9 0.086 12.9 3.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CLN3 PF02487.17 CDI82302.1 - 0.076 12.1 3.7 0.088 11.8 3.7 1.1 1 0 0 1 1 1 0 CLN3 protein Peroxin-13_N PF04088.13 CDI82302.1 - 0.09 13.1 4.5 0.14 12.4 4.5 1.5 1 1 0 1 1 1 0 Peroxin 13, N-terminal region PTPRCAP PF15713.5 CDI82302.1 - 0.1 12.9 8.0 0.14 12.5 8.0 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CSG2 PF16965.5 CDI82302.1 - 0.13 11.2 1.2 0.15 11.0 1.2 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator eIF-3_zeta PF05091.12 CDI82302.1 - 0.13 11.3 10.2 0.15 11.0 10.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Oxidored_q3 PF00499.20 CDI82302.1 - 0.15 11.8 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Serinc PF03348.15 CDI82302.1 - 0.17 10.8 1.3 0.2 10.6 1.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Kei1 PF08552.11 CDI82302.1 - 0.18 11.7 5.0 0.26 11.1 5.0 1.3 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Presenilin PF01080.17 CDI82302.1 - 0.21 10.3 8.4 0.27 10.0 8.4 1.1 1 0 0 1 1 1 0 Presenilin DUF3984 PF13136.6 CDI82302.1 - 0.25 10.7 8.9 0.31 10.4 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) OATP PF03137.20 CDI82302.1 - 0.29 9.4 1.7 0.33 9.2 1.7 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Band_3_cyto PF07565.13 CDI82302.1 - 0.64 9.8 10.0 0.82 9.4 10.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Consortin_C PF15281.6 CDI82302.1 - 0.64 10.0 5.0 0.35 10.9 2.8 1.7 1 1 1 2 2 2 0 Consortin C-terminus ALG3 PF05208.13 CDI82302.1 - 0.69 9.3 4.2 0.78 9.1 4.2 1.1 1 0 0 1 1 1 0 ALG3 protein Zip PF02535.22 CDI82302.1 - 0.8 8.9 3.6 0.88 8.7 3.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FAM176 PF14851.6 CDI82302.1 - 0.86 9.3 5.8 0.051 13.2 1.0 1.4 2 0 0 2 2 1 0 FAM176 family Sec16 PF12932.7 CDI82302.1 - 1.1 9.9 8.6 4.7 7.8 1.8 2.2 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region PigN PF04987.14 CDI82302.1 - 1.3 7.9 4.1 1.5 7.6 4.1 1.3 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) FAM150 PF15129.6 CDI82302.1 - 1.3 9.2 10.7 0.2 11.8 6.6 1.7 2 0 0 2 2 2 0 FAM150 family NapE PF06796.11 CDI82302.1 - 1.4 8.5 2.8 4.1 7.0 1.2 2.5 2 1 0 2 2 2 0 Periplasmic nitrate reductase protein NapE DUF2227 PF09988.9 CDI82302.1 - 1.4 8.7 4.1 1.4 8.7 3.5 1.3 1 1 0 1 1 1 0 Uncharacterized metal-binding protein (DUF2227) GET2 PF08690.10 CDI82302.1 - 2.6 7.6 14.1 3.4 7.3 14.1 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 DUF4484 PF14831.6 CDI82302.1 - 2.9 7.9 9.3 3.7 7.5 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) DUF1180 PF06679.12 CDI82302.1 - 3.4 8.0 7.2 0.85 10.0 3.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) V_ATPase_I PF01496.19 CDI82302.1 - 3.6 5.4 15.3 4.3 5.1 15.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MTABC_N PF16185.5 CDI82302.1 - 5 6.6 9.3 6.6 6.1 9.0 1.3 1 1 0 1 1 1 0 Mitochondrial ABC-transporter N-terminal five TM region Anoctamin PF04547.12 CDI82302.1 - 6.2 5.5 7.7 6.9 5.4 7.7 1.0 1 0 0 1 1 1 0 Calcium-activated chloride channel AIF_C PF14721.6 CDI82302.1 - 8.6 6.7 8.0 0.39 11.1 2.7 1.4 2 0 0 2 2 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Ank_5 PF13857.6 CDI82306.1 - 0.059 13.7 0.0 0.27 11.6 0.0 2.0 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Surfac_D-trimer PF09006.11 CDI82307.1 - 0.09 12.7 7.4 0.023 14.6 1.7 2.6 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation Prefoldin PF02996.17 CDI82307.1 - 0.2 11.6 10.4 0.1 12.5 1.7 2.9 2 0 0 2 2 2 0 Prefoldin subunit ApoLp-III PF07464.11 CDI82307.1 - 1.9 8.6 9.1 0.13 12.4 1.3 2.5 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Phage_GP20 PF06810.11 CDI82307.1 - 2.1 8.2 9.1 1.4 8.7 2.2 2.4 2 0 0 2 2 2 0 Phage minor structural protein GP20 Fzo_mitofusin PF04799.13 CDI82307.1 - 5.6 6.5 7.1 4.1 6.9 1.4 2.5 2 0 0 2 2 2 0 fzo-like conserved region Tropomyosin PF00261.20 CDI82307.1 - 6.5 6.0 27.3 0.39 10.0 7.4 3.4 3 0 0 3 3 3 0 Tropomyosin Spc7 PF08317.11 CDI82307.1 - 7.7 5.3 22.7 1.2 7.9 4.4 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF2722 PF10846.8 CDI82309.1 - 9.6e-05 21.5 2.9 9.6e-05 21.5 2.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Ribosomal_L37e PF01907.19 CDI82309.1 - 0.00035 20.7 0.6 0.00082 19.5 0.6 1.6 1 0 0 1 1 1 1 Ribosomal protein L37e Lactamase_B_2 PF12706.7 CDI82309.1 - 0.00059 19.4 0.0 0.00093 18.8 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain TFIIA PF03153.13 CDI82309.1 - 0.00071 19.7 4.5 0.00071 19.7 4.5 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Amidohydro_2 PF04909.14 CDI82309.1 - 0.072 12.9 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 Amidohydrolase Spt20 PF12090.8 CDI82309.1 - 0.12 12.0 15.8 0.17 11.5 15.8 1.2 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI82314.1 - 7.5e-06 26.8 3.4 1.2e-05 26.2 3.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) TssO PF17561.2 CDI82314.1 - 9.2e-06 25.8 4.1 9.2e-06 25.8 4.1 1.3 2 0 0 2 2 1 1 Type VI secretion system, TssO EphA2_TM PF14575.6 CDI82314.1 - 0.00014 22.7 4.4 0.00014 22.7 4.4 2.0 1 1 1 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain BatD PF13584.6 CDI82314.1 - 0.00023 20.2 0.1 0.00023 20.1 0.1 1.1 1 0 0 1 1 1 1 Oxygen tolerance DUF2615 PF11027.8 CDI82314.1 - 0.00041 20.5 0.1 0.00051 20.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) FHIPEP PF00771.20 CDI82314.1 - 0.00058 18.5 1.3 0.00058 18.5 1.3 1.0 1 0 0 1 1 1 1 FHIPEP family DUF4381 PF14316.6 CDI82314.1 - 0.00059 20.1 2.1 0.00083 19.6 2.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) MscS_TM PF12794.7 CDI82314.1 - 0.00088 18.2 5.2 0.00096 18.1 5.2 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel inner membrane domain 1 GRP PF07172.11 CDI82314.1 - 0.00093 19.8 2.8 0.00093 19.8 2.8 1.5 1 1 1 2 2 1 1 Glycine rich protein family CBP_BcsG PF11658.8 CDI82314.1 - 0.0011 17.5 1.2 0.0011 17.5 1.2 1.0 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG Ac76 PF05814.11 CDI82314.1 - 0.0012 18.8 1.4 0.0016 18.4 1.4 1.2 1 0 0 1 1 1 1 Orf76 (Ac76) OAD_gamma PF04277.13 CDI82314.1 - 0.0013 19.3 0.0 0.0013 19.3 0.0 1.5 2 0 0 2 2 1 1 Oxaloacetate decarboxylase, gamma chain Pex24p PF06398.11 CDI82314.1 - 0.0013 17.8 0.1 0.0014 17.7 0.1 1.0 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Connexin PF00029.19 CDI82314.1 - 0.0017 18.2 1.3 0.002 18.0 1.3 1.3 1 0 0 1 1 1 1 Connexin tRNA_anti-like PF12869.7 CDI82314.1 - 0.0023 17.6 0.2 0.0023 17.6 0.2 1.1 1 0 0 1 1 1 1 tRNA_anti-like MAPEG PF01124.18 CDI82314.1 - 0.0024 17.8 0.1 0.0035 17.3 0.1 1.3 1 0 0 1 1 1 1 MAPEG family FAM209 PF15206.6 CDI82314.1 - 0.0031 17.3 0.7 0.0036 17.1 0.7 1.1 1 0 0 1 1 1 1 FAM209 family V_ATPase_I PF01496.19 CDI82314.1 - 0.0036 15.3 7.6 0.0039 15.2 7.6 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI82314.1 - 0.0037 16.4 1.5 0.0038 16.3 1.5 1.0 1 0 0 1 1 1 1 CLN3 protein SID-1_RNA_chan PF13965.6 CDI82314.1 - 0.0048 15.4 0.4 0.0049 15.3 0.4 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DUF2140 PF09911.9 CDI82314.1 - 0.0049 16.4 1.2 0.0064 16.1 1.2 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2140) OATP PF03137.20 CDI82314.1 - 0.005 15.2 1.2 0.0059 15.0 1.2 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF3397 PF11877.8 CDI82314.1 - 0.0054 16.9 1.0 0.0065 16.7 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3397) Tmemb_9 PF05434.11 CDI82314.1 - 0.0055 16.6 8.5 0.0068 16.3 8.5 1.3 1 1 0 1 1 1 1 TMEM9 Tetraspanin PF00335.20 CDI82314.1 - 0.0065 16.2 0.3 0.008 15.9 0.3 1.2 1 0 0 1 1 1 1 Tetraspanin family COPI_assoc PF08507.10 CDI82314.1 - 0.007 16.4 0.2 0.0084 16.2 0.2 1.1 1 0 0 1 1 1 1 COPI associated protein CcmH PF03918.14 CDI82314.1 - 0.0073 15.6 4.7 0.011 15.1 4.7 1.4 1 1 0 1 1 1 1 Cytochrome C biogenesis protein Syndecan PF01034.20 CDI82314.1 - 0.0075 16.2 0.0 0.0075 16.2 0.0 1.6 2 0 0 2 2 1 1 Syndecan domain COX2_TM PF02790.15 CDI82314.1 - 0.0079 16.3 0.7 0.0079 16.3 0.7 1.5 1 1 0 1 1 1 1 Cytochrome C oxidase subunit II, transmembrane domain OSTbeta PF15048.6 CDI82314.1 - 0.0094 16.1 2.4 0.011 15.8 2.4 1.2 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein ABC_membrane PF00664.23 CDI82314.1 - 0.0094 15.6 0.1 0.01 15.5 0.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region O-antigen_lig PF13425.6 CDI82314.1 - 0.01 14.6 0.4 0.011 14.6 0.4 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein YfhO PF09586.10 CDI82314.1 - 0.011 14.0 2.5 0.012 13.9 2.5 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Cytochrom_B_N_2 PF13631.6 CDI82314.1 - 0.012 15.7 0.3 0.013 15.5 0.3 1.3 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB TMEM51 PF15345.6 CDI82314.1 - 0.012 15.5 11.7 0.012 15.5 11.7 1.4 2 0 0 2 2 1 0 Transmembrane protein 51 Scs3p PF10261.9 CDI82314.1 - 0.013 15.0 2.3 0.015 14.8 2.3 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF4010 PF13194.6 CDI82314.1 - 0.015 15.0 0.1 0.016 14.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) RskA PF10099.9 CDI82314.1 - 0.017 15.4 0.3 0.017 15.4 0.3 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA FAM176 PF14851.6 CDI82314.1 - 0.024 14.3 5.2 0.025 14.3 5.1 1.2 1 1 0 1 1 1 0 FAM176 family 7TM_GPCR_Srv PF10323.9 CDI82314.1 - 0.025 13.9 0.4 0.029 13.7 0.4 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv TauE PF01925.19 CDI82314.1 - 0.026 14.1 0.0 0.026 14.1 0.0 1.1 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE NicO PF03824.16 CDI82314.1 - 0.027 13.8 0.6 0.025 13.9 0.6 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein DUF3278 PF11683.8 CDI82314.1 - 0.03 14.4 0.6 0.032 14.3 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3278) DUF3357 PF11837.8 CDI82314.1 - 0.03 14.8 0.4 0.03 14.8 0.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) TRAP_alpha PF03896.16 CDI82314.1 - 0.031 13.5 2.1 0.038 13.2 2.1 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF3169 PF11368.8 CDI82314.1 - 0.031 13.8 0.6 0.037 13.6 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) CopD PF05425.13 CDI82314.1 - 0.033 14.6 1.4 0.041 14.3 1.4 1.3 1 1 0 1 1 1 0 Copper resistance protein D DcuA_DcuB PF03605.14 CDI82314.1 - 0.038 12.9 0.8 0.038 12.9 0.8 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Dpy19 PF10034.9 CDI82314.1 - 0.041 12.1 2.6 0.041 12.1 2.6 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation WBP-1 PF11669.8 CDI82314.1 - 0.042 14.5 5.9 0.054 14.1 5.7 1.4 1 1 0 1 1 1 0 WW domain-binding protein 1 Ni_hydr_CYTB PF01292.20 CDI82314.1 - 0.044 13.4 0.2 0.071 12.7 0.2 1.5 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 Herpes_LMP1 PF05297.11 CDI82314.1 - 0.047 12.9 1.6 0.051 12.8 1.6 1.0 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DUF4131 PF13567.6 CDI82314.1 - 0.049 13.3 0.1 0.06 13.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) EIIBC-GUT_N PF03612.14 CDI82314.1 - 0.054 13.2 1.7 0.052 13.3 1.7 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Gram_pos_anchor PF00746.21 CDI82314.1 - 0.056 13.4 0.2 0.097 12.6 0.2 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif ABC2_membrane_2 PF12679.7 CDI82314.1 - 0.057 12.7 1.1 0.061 12.6 1.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein SHR3_chaperone PF08229.11 CDI82314.1 - 0.058 12.4 5.7 0.063 12.3 5.7 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 ALG3 PF05208.13 CDI82314.1 - 0.06 12.8 2.6 0.064 12.7 2.6 1.1 1 0 0 1 1 1 0 ALG3 protein Wzy_C PF04932.15 CDI82314.1 - 0.066 12.9 0.0 0.073 12.7 0.0 1.1 1 0 0 1 1 1 0 O-Antigen ligase MFS_2 PF13347.6 CDI82314.1 - 0.069 11.7 0.1 0.071 11.7 0.1 1.0 1 0 0 1 1 1 0 MFS/sugar transport protein FPN1 PF06963.12 CDI82314.1 - 0.076 11.6 0.6 0.081 11.5 0.6 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Folate_carrier PF01770.18 CDI82314.1 - 0.079 11.7 1.2 0.088 11.5 1.2 1.2 1 0 0 1 1 1 0 Reduced folate carrier DUF2227 PF09988.9 CDI82314.1 - 0.09 12.7 1.1 0.092 12.6 1.1 1.1 1 0 0 1 1 1 0 Uncharacterized metal-binding protein (DUF2227) NEMP PF10225.9 CDI82314.1 - 0.092 12.4 5.5 0.097 12.3 5.5 1.0 1 0 0 1 1 1 0 NEMP family MscL PF01741.18 CDI82314.1 - 0.1 12.9 0.1 0.12 12.6 0.1 1.2 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL DUF1345 PF07077.11 CDI82314.1 - 0.1 12.3 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) DUF5313 PF17240.2 CDI82314.1 - 0.11 12.9 2.4 0.12 12.8 2.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5313) Serinc PF03348.15 CDI82314.1 - 0.11 11.4 0.2 0.13 11.1 0.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) MFS_Mycoplasma PF07672.13 CDI82314.1 - 0.11 11.7 0.7 0.12 11.6 0.7 1.2 1 0 0 1 1 1 0 Mycoplasma MFS transporter RseC_MucC PF04246.12 CDI82314.1 - 0.12 12.4 1.8 0.14 12.1 1.8 1.3 1 1 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Sulf_transp PF04143.14 CDI82314.1 - 0.13 11.8 0.1 0.14 11.7 0.1 1.1 1 0 0 1 1 1 0 Sulphur transport DUF1772 PF08592.11 CDI82314.1 - 0.15 12.4 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) 7tm_1 PF00001.21 CDI82314.1 - 0.15 11.4 0.3 0.16 11.3 0.3 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) K_trans PF02705.16 CDI82314.1 - 0.16 10.5 0.6 0.15 10.6 0.6 1.1 1 0 0 1 1 1 0 K+ potassium transporter MFS_1_like PF12832.7 CDI82314.1 - 0.21 10.4 0.3 0.22 10.3 0.3 1.1 1 0 0 1 1 1 0 MFS_1 like family PigN PF04987.14 CDI82314.1 - 0.23 10.3 7.9 0.3 9.9 7.9 1.3 1 1 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Mem_trans PF03547.18 CDI82314.1 - 0.25 9.7 2.5 0.26 9.6 2.5 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF2681 PF10883.8 CDI82314.1 - 0.28 11.6 18.9 0.53 10.7 18.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) MSP1a PF11670.8 CDI82314.1 - 0.32 10.2 0.9 0.35 10.1 0.9 1.1 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) MLANA PF14991.6 CDI82314.1 - 1.1 9.6 5.0 0.1 12.9 0.6 1.5 1 1 1 2 2 1 0 Protein melan-A Ctr PF04145.15 CDI82314.1 - 2.4 8.7 9.8 3.4 8.3 9.8 1.4 1 1 0 1 1 1 0 Ctr copper transporter family TMEM208_SND2 PF05620.11 CDI82314.1 - 6 6.6 11.1 8.9 6.1 11.1 1.4 1 1 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DUF3464 PF11947.8 CDI82314.1 - 6.9 6.4 9.4 8.6 6.1 9.4 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 UPF0542 PF15086.6 CDI82314.1 - 9.7 6.2 11.2 28 4.7 11.2 1.8 1 1 0 1 1 1 0 Uncharacterised protein family UPF0542 TniB PF05621.11 CDI82316.1 - 0.0042 16.5 1.3 0.0053 16.2 1.3 1.2 1 0 0 1 1 1 1 Bacterial TniB protein DUF3357 PF11837.8 CDI82316.1 - 0.0051 17.2 0.2 0.0069 16.8 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3357) DUF2722 PF10846.8 CDI82316.1 - 0.0066 15.4 1.6 0.0066 15.4 1.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Pyr_redox_2 PF07992.14 CDI82316.1 - 0.013 14.7 0.4 0.14 11.4 0.2 2.0 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Coiled-coil_56 PF09813.9 CDI82316.1 - 0.016 15.2 2.7 0.016 15.2 2.7 2.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 56 Methyltransf_34 PF11312.8 CDI82316.1 - 0.022 14.0 1.1 0.031 13.5 1.1 1.1 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase AAA_22 PF13401.6 CDI82316.1 - 0.038 14.3 4.2 0.068 13.4 4.2 1.3 1 0 0 1 1 1 0 AAA domain NAD_binding_8 PF13450.6 CDI82316.1 - 0.045 14.0 0.1 0.084 13.1 0.1 1.6 1 1 0 1 1 1 0 NAD(P)-binding Rossmann-like domain SLC12 PF03522.15 CDI82316.1 - 0.068 12.2 4.7 0.084 11.9 4.7 1.2 1 0 0 1 1 1 0 Solute carrier family 12 PIP5K PF01504.18 CDI82316.1 - 0.072 12.3 6.2 0.095 11.9 6.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Rxt3 PF08642.10 CDI82316.1 - 0.074 13.8 6.0 0.16 12.8 0.1 2.1 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 Topoisom_I_N PF02919.15 CDI82316.1 - 0.14 11.6 4.0 2.2 7.7 0.7 2.1 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment DUF4366 PF14283.6 CDI82316.1 - 0.15 12.1 3.8 1.5 8.9 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) Lin-8 PF03353.15 CDI82316.1 - 0.16 11.5 8.9 0.2 11.2 8.9 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist NAD_binding_9 PF13454.6 CDI82316.1 - 0.19 11.7 0.2 0.19 11.7 0.2 2.7 3 1 0 3 3 2 0 FAD-NAD(P)-binding DUF4834 PF16118.5 CDI82316.1 - 0.2 12.6 13.9 0.79 10.7 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) AUX_IAA PF02309.16 CDI82316.1 - 0.24 11.3 4.9 0.28 11.0 4.9 1.1 1 0 0 1 1 1 0 AUX/IAA family Activator_LAG-3 PF11498.8 CDI82316.1 - 0.37 9.7 48.1 0.46 9.4 48.1 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 PepSY_TM_like_2 PF16357.5 CDI82316.1 - 0.44 10.5 3.9 0.54 10.2 3.9 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like CDC45 PF02724.14 CDI82316.1 - 0.48 8.7 6.6 0.64 8.2 6.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Sox_N PF12444.8 CDI82316.1 - 0.54 11.4 3.6 2.4 9.4 0.4 2.1 2 0 0 2 2 2 0 Sox developmental protein N terminal Presenilin PF01080.17 CDI82316.1 - 0.58 8.9 11.2 0.77 8.5 11.2 1.1 1 0 0 1 1 1 0 Presenilin Rpp20 PF12328.8 CDI82316.1 - 0.59 10.1 10.8 1.1 9.3 1.0 2.2 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P PRC2_HTH_1 PF18118.1 CDI82316.1 - 0.61 10.9 5.1 3.4 8.5 0.1 2.1 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Ndc1_Nup PF09531.10 CDI82316.1 - 1.2 7.7 5.8 1.7 7.2 5.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 CDI82316.1 - 1.4 7.1 17.1 1.6 6.9 17.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3381 PF11861.8 CDI82316.1 - 1.4 8.7 13.8 0.32 10.8 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) DUF4660 PF15559.6 CDI82316.1 - 1.6 9.1 8.9 0.41 11.0 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4660) Phage_holin_2_4 PF16082.5 CDI82316.1 - 1.7 8.4 0.0 1.7 8.4 0.0 2.2 2 0 0 2 2 1 0 Bacteriophage holin family, superfamily II-like 7TM_GPCR_Srv PF10323.9 CDI82316.1 - 1.7 7.9 9.3 3.8 6.8 9.3 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv DUF2828 PF11443.8 CDI82316.1 - 1.8 6.6 8.5 2.3 6.2 8.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Neur_chan_memb PF02932.16 CDI82316.1 - 1.8 8.6 6.8 2.5 8.1 6.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Baculo_PP31 PF05311.11 CDI82316.1 - 1.9 7.9 8.8 2.4 7.6 8.8 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF2489 PF10675.9 CDI82316.1 - 2 8.4 23.4 0.3 11.0 5.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) MDM10 PF12519.8 CDI82316.1 - 2.5 6.9 6.3 3.1 6.6 6.3 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF3464 PF11947.8 CDI82316.1 - 3.7 7.3 11.0 5.6 6.7 0.3 2.1 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 WASH-7_C PF14746.6 CDI82316.1 - 7.6 6.2 13.4 0.45 10.2 0.5 2.1 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal eIF_4EBP PF05456.11 CDI82316.1 - 8.1 6.4 11.8 8.4 6.4 0.6 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) USP8_interact PF08941.10 CDI82316.1 - 9 6.1 15.4 1.5 8.6 0.8 2.1 2 0 0 2 2 2 0 USP8 interacting GREB1 PF15782.5 CDI82319.1 - 5.3 4.0 5.8 6.3 3.8 5.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 CDI82320.1 - 0.011 14.4 9.8 0.015 13.9 9.8 1.2 1 0 0 1 1 1 0 Macoilin family Spt20 PF12090.8 CDI82320.1 - 0.35 10.4 17.2 0.024 14.3 12.5 1.4 2 0 0 2 2 2 0 Spt20 family FliD_N PF02465.18 CDI82320.1 - 0.56 10.9 12.1 0.1 13.3 7.7 1.8 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF3138 PF11336.8 CDI82320.1 - 1.3 7.5 8.9 1.4 7.4 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) RIFIN PF02009.16 CDI82320.1 - 1.5 8.6 4.0 2.2 8.1 4.0 1.2 1 0 0 1 1 1 0 Rifin Roughex PF06020.11 CDI82320.1 - 8.5 5.4 9.1 11 4.9 9.1 1.1 1 0 0 1 1 1 0 Drosophila roughex protein DUF3464 PF11947.8 CDI82324.1 - 0.015 15.0 2.7 0.015 15.0 2.7 3.0 1 1 2 3 3 3 0 Photosynthesis affected mutant 68 TFIIA PF03153.13 CDI82324.1 - 0.058 13.4 47.3 0.018 15.1 44.6 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Phage_holin_3_3 PF16083.5 CDI82324.1 - 0.068 13.3 6.2 0.39 10.9 0.2 2.4 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III DUF1616 PF07760.11 CDI82324.1 - 0.14 11.5 0.0 0.14 11.5 0.0 2.2 1 1 0 2 2 1 0 Protein of unknown function (DUF1616) VIT1 PF01988.19 CDI82324.1 - 0.15 11.9 19.0 0.03 14.2 9.0 2.2 1 1 1 2 2 2 0 VIT family CTI PF06934.11 CDI82324.1 - 0.38 9.2 13.7 0.48 8.9 13.7 1.1 1 0 0 1 1 1 0 Fatty acid cis/trans isomerase (CTI) Med15 PF09606.10 CDI82324.1 - 1.2 7.8 44.6 2 7.0 44.6 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Tim54 PF11711.8 CDI82324.1 - 1.8 7.3 18.8 4 6.1 0.2 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 ALMT PF11744.8 CDI82324.1 - 2.2 7.0 13.3 0.2 10.4 8.7 1.5 2 0 0 2 2 2 0 Aluminium activated malate transporter DUF4231 PF14015.6 CDI82324.1 - 3 8.4 8.2 0.52 10.8 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) PBP1_TM PF14812.6 CDI82324.1 - 4.3 7.8 12.9 0.25 11.7 1.7 3.0 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Gti1_Pac2 PF09729.9 CDI82324.1 - 4.8 7.2 15.0 2.4 8.2 11.9 1.9 2 0 0 2 2 2 0 Gti1/Pac2 family NPR3 PF03666.13 CDI82324.1 - 6.9 5.3 18.6 0.54 9.0 13.3 1.6 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Sec62 PF03839.16 CDI82324.1 - 7.3 6.0 16.2 1.9 7.9 12.3 1.9 2 0 0 2 2 2 0 Translocation protein Sec62 O-antigen_lig PF13425.6 CDI82324.1 - 8.7 5.0 6.3 14 4.3 6.3 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SMYLE_N PF18615.1 CDI82324.1 - 8.9 5.8 15.9 3.1 7.3 10.1 2.0 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain DUF2052 PF09747.9 CDI82324.1 - 9.9 6.2 29.1 7.9 6.5 2.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Torus PF16131.5 CDI82326.1 - 3.2e-31 108.2 0.5 3.2e-31 108.2 0.5 2.5 2 1 1 3 3 3 1 Torus domain RRM_1 PF00076.22 CDI82326.1 - 0.00076 19.3 0.0 0.0018 18.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 CDI82326.1 - 0.26 11.4 8.8 0.48 10.6 8.8 1.5 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH_2 PF14608.6 CDI82326.1 - 2.8 8.6 6.7 5.4 7.6 6.7 1.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 CDI82326.1 - 3 7.7 9.2 5.5 6.9 9.2 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger PNK3P PF08645.11 CDI82327.1 - 0.022 14.4 0.0 0.06 13.0 0.0 1.6 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase Hydrolase PF00702.26 CDI82327.1 - 0.11 12.8 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF2608 PF11019.8 CDI82327.1 - 0.18 11.2 0.3 0.32 10.4 0.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2608) DUF3682 PF12446.8 CDI82330.1 - 0.0055 17.2 16.8 0.0055 17.2 16.8 8.0 5 2 3 8 8 8 1 Protein of unknown function (DUF3682) FR47 PF08445.10 CDI82330.1 - 0.16 11.9 0.1 0.6 10.1 0.0 2.0 2 0 0 2 2 2 0 FR47-like protein RskA PF10099.9 CDI82340.1 - 1.8e-10 41.4 1.8 1.8e-10 41.4 1.8 4.7 1 1 2 3 3 3 1 Anti-sigma-K factor rskA Zip PF02535.22 CDI82340.1 - 0.00023 20.5 3.2 0.00023 20.5 3.2 2.2 2 0 0 2 2 2 1 ZIP Zinc transporter FAP PF07174.11 CDI82340.1 - 0.2 11.1 23.8 0.29 10.6 23.8 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Vfa1 PF08432.10 CDI82340.1 - 0.43 10.9 58.7 0.055 13.8 13.2 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 BAF1_ABF1 PF04684.13 CDI82340.1 - 0.86 8.6 53.7 0.02 14.0 9.9 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor DUF2052 PF09747.9 CDI82340.1 - 7.7 6.6 61.6 8.6 6.4 15.9 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) RskA PF10099.9 CDI82343.1 - 7.2e-08 32.9 33.6 0.0013 19.1 0.9 3.5 2 1 1 3 3 3 3 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI82343.1 - 0.087 11.6 20.0 0.78 8.4 1.1 2.1 2 0 0 2 2 2 0 Presenilin MRP-S31 PF15433.6 CDI82343.1 - 0.16 11.6 23.6 0.25 11.0 12.6 2.2 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 PAP1 PF08601.10 CDI82343.1 - 0.36 10.5 20.7 1.5 8.4 2.9 2.2 2 0 0 2 2 2 0 Transcription factor PAP1 PAP2 PF01569.21 CDI82343.1 - 0.79 9.5 5.8 4.4 7.1 0.0 2.7 2 1 0 2 2 2 0 PAP2 superfamily Lin-8 PF03353.15 CDI82343.1 - 1 8.9 27.4 1.2 8.6 5.4 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF5519 PF17648.1 CDI82343.1 - 1.9 8.4 11.2 4.9 7.0 1.2 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5519) ANAPC_CDC26 PF10471.9 CDI82343.1 - 2.3 9.1 53.7 1.3 9.9 11.9 4.4 4 0 0 4 4 4 0 Anaphase-promoting complex APC subunit CDC26 Conotoxin PF02950.17 CDI82343.1 - 3.7 8.6 23.7 1.5 9.9 1.2 4.7 5 0 0 5 5 5 0 Conotoxin OAD_gamma PF04277.13 CDI82343.1 - 5.1 7.8 14.6 9.1 7.0 3.0 3.7 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain XRN_M PF17846.1 CDI82343.1 - 6.9 5.5 9.6 0.41 9.5 3.2 1.9 2 0 0 2 2 2 0 Xrn1 helical domain DUF1764 PF08576.10 CDI82346.1 - 0.29 12.0 22.4 0.32 11.9 22.4 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) PUF PF00806.19 CDI82347.1 - 4.9e-38 126.7 1.9 4.9e-07 29.1 0.0 6.3 6 0 0 6 6 6 6 Pumilio-family RNA binding repeat TBPIP PF07106.13 CDI82347.1 - 0.027 14.4 0.5 2.2 8.3 0.0 3.8 6 0 0 6 6 6 0 TBPIP/Hop2 winged helix domain CCDC53 PF10152.9 CDI82347.1 - 0.49 10.8 7.1 0.081 13.3 1.0 2.7 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex Pkinase PF00069.25 CDI82348.1 - 5.6e-31 107.9 0.0 2.1e-16 60.1 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI82348.1 - 1.4e-12 47.5 0.0 4.2e-06 26.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CDI82348.1 - 2.4e-06 27.1 0.8 0.023 14.0 0.0 2.7 3 0 0 3 3 2 2 Kinase-like APH PF01636.23 CDI82348.1 - 0.00026 21.0 1.0 0.00026 21.0 1.0 3.3 2 1 2 4 4 3 1 Phosphotransferase enzyme family PIP49_C PF12260.8 CDI82348.1 - 0.0052 16.4 0.2 0.011 15.4 0.2 1.5 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Med15 PF09606.10 CDI82348.1 - 0.015 14.1 23.1 0.1 11.2 5.6 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI82348.1 - 0.062 13.3 35.6 0.053 13.5 15.2 2.6 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI82348.1 - 0.088 12.4 39.2 0.58 9.7 19.7 2.3 2 0 0 2 2 2 0 Spt20 family RPA43_OB PF17875.1 CDI82348.1 - 0.24 12.0 6.1 2.7 8.6 4.9 2.5 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I DDHD PF02862.17 CDI82348.1 - 0.32 11.1 8.4 1.9 8.6 4.3 2.3 2 0 0 2 2 2 0 DDHD domain CCDC53 PF10152.9 CDI82348.1 - 0.33 11.4 9.7 0.46 10.9 3.0 2.6 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex DUF2722 PF10846.8 CDI82348.1 - 0.63 8.9 27.1 0.047 12.6 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) EOS1 PF12326.8 CDI82348.1 - 1.1 9.1 3.3 22 4.9 1.1 2.5 2 0 0 2 2 2 0 N-glycosylation protein Ctr PF04145.15 CDI82348.1 - 1.3 9.7 4.7 8.9 6.9 3.0 2.4 2 0 0 2 2 2 0 Ctr copper transporter family DUF4820 PF16091.5 CDI82348.1 - 1.4 8.2 8.6 0.58 9.5 1.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF4647 PF15504.6 CDI82348.1 - 1.6 7.7 16.3 0.13 11.4 4.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) CDC45 PF02724.14 CDI82348.1 - 2.2 6.5 17.8 0.054 11.8 9.9 1.9 2 0 0 2 2 2 0 CDC45-like protein OATP PF03137.20 CDI82348.1 - 2.2 6.5 6.1 30 2.7 0.0 2.3 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family BRF1 PF07741.13 CDI82348.1 - 2.6 8.5 15.8 20 5.6 0.0 2.5 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Peptidase_S49_N PF08496.10 CDI82348.1 - 2.6 8.1 12.2 2.7 8.0 3.7 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Neur_chan_memb PF02932.16 CDI82348.1 - 2.7 8.0 10.4 6.8 6.7 4.9 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 CDI82348.1 - 4.5 7.0 16.0 1.6 8.5 8.9 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Rxt3 PF08642.10 CDI82348.1 - 5.6 7.7 6.1 20 6.0 2.2 2.4 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 Connexin PF00029.19 CDI82348.1 - 6.1 6.5 11.9 69 3.1 0.0 2.2 2 0 0 2 2 2 0 Connexin PTPRCAP PF15713.5 CDI82348.1 - 6.4 7.0 27.8 0.76 10.1 11.2 3.7 3 0 0 3 3 3 0 Protein tyrosine phosphatase receptor type C-associated CPSF100_C PF13299.6 CDI82348.1 - 8.7 6.5 10.9 5.5 7.1 5.0 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal PepSY_TM PF03929.16 CDI82348.1 - 8.8 5.9 6.7 11 5.6 1.0 2.9 3 0 0 3 3 3 0 PepSY-associated TM region Tim54 PF11711.8 CDI82348.1 - 9.3 4.9 11.9 0.39 9.5 3.6 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 RskA PF10099.9 CDI82351.1 - 2.7e-06 27.8 7.1 2.7e-06 27.8 7.1 8.3 1 1 2 3 3 3 1 Anti-sigma-K factor rskA HET PF06985.11 CDI82361.1 - 0.048 14.0 0.0 0.068 13.5 0.0 1.3 1 0 0 1 1 1 0 Heterokaryon incompatibility protein (HET) Miga PF10265.9 CDI82362.1 - 0.55 9.2 21.0 0.68 8.8 21.0 1.1 1 0 0 1 1 1 0 Mitoguardin DUF5427 PF10310.9 CDI82362.1 - 0.94 8.4 31.1 1.2 8.0 31.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF3474 PF11960.8 CDI82362.1 - 1.2 9.3 7.6 0.72 10.0 5.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3474) TMEM51 PF15345.6 CDI82362.1 - 1.3 8.8 35.8 1.8 8.3 35.8 1.4 1 1 0 1 1 1 0 Transmembrane protein 51 Peptidase_U57 PF05582.12 CDI82362.1 - 2.4 7.4 16.8 3.3 6.9 16.8 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Sin_N PF04801.13 CDI82362.1 - 2.9 7.0 38.4 4.2 6.5 38.4 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region Peptidase_S64 PF08192.11 CDI82362.1 - 5.9 5.2 31.5 6.7 5.1 31.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 Plasmodium_Vir PF05795.11 CDI82362.1 - 6.5 6.1 15.4 8 5.8 15.4 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SR-25 PF10500.9 CDI82362.1 - 8 6.0 29.6 54 3.3 29.7 1.8 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI82367.1 - 0.0051 17.1 14.4 0.0073 16.6 14.4 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI82367.1 - 0.0053 16.4 19.4 0.0067 16.1 19.4 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4071 PF13281.6 CDI82367.1 - 0.0074 15.4 2.6 0.008 15.3 2.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4071) TFIIA PF03153.13 CDI82367.1 - 0.048 13.6 18.9 0.056 13.4 18.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TAF1D PF15333.6 CDI82367.1 - 0.089 12.5 9.6 0.13 11.9 9.6 1.3 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D MCM_bind PF09739.9 CDI82367.1 - 0.11 11.0 6.4 0.12 10.8 6.4 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor TrbI PF03743.14 CDI82367.1 - 0.26 11.1 8.1 0.34 10.7 8.1 1.2 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein Dynamin_N PF00350.23 CDI82367.1 - 0.37 10.8 5.6 1.1 9.3 5.6 1.7 1 1 0 1 1 1 0 Dynamin family FapA PF03961.13 CDI82367.1 - 0.54 8.8 2.6 0.62 8.6 2.6 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A FAM199X PF15814.5 CDI82367.1 - 1.1 8.3 19.3 1.3 8.0 19.3 1.2 1 0 0 1 1 1 0 Protein family FAM199X Nop53 PF07767.11 CDI82367.1 - 1.8 7.9 16.9 2.6 7.4 16.9 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) XAP5 PF04921.14 CDI82367.1 - 1.9 8.2 9.3 2.9 7.7 9.3 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator Bul1_N PF04425.12 CDI82367.1 - 2 7.1 6.6 2.3 6.9 6.6 1.1 1 0 0 1 1 1 0 Bul1 N terminus FAA_hydrolase_N PF09298.11 CDI82367.1 - 2.3 8.4 9.3 2.6 8.3 8.5 1.5 1 1 0 1 1 1 0 Fumarylacetoacetase N-terminal DUF572 PF04502.13 CDI82367.1 - 2.6 7.6 12.0 3.9 7.0 12.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) GREB1 PF15782.5 CDI82367.1 - 2.6 5.0 12.6 2.9 4.9 12.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOBP PF15279.6 CDI82367.1 - 2.7 8.5 10.9 3 8.4 10.9 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein PA26 PF04636.13 CDI82367.1 - 3.5 6.4 7.9 3.7 6.4 7.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) RR_TM4-6 PF06459.12 CDI82367.1 - 4.1 7.1 8.8 5.9 6.6 8.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4407 PF14362.6 CDI82367.1 - 4.3 6.6 16.8 6.1 6.1 16.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Suf PF05843.14 CDI82367.1 - 4.8 7.1 12.4 5.7 6.8 12.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) ThiD2 PF17792.1 CDI82367.1 - 4.8 7.7 11.1 1.3 9.5 7.6 1.7 1 1 1 2 2 2 0 ThiD2 family Presenilin PF01080.17 CDI82367.1 - 5.1 5.8 13.0 6.1 5.5 13.0 1.2 1 0 0 1 1 1 0 Presenilin LMBR1 PF04791.16 CDI82367.1 - 6.3 5.6 8.4 7.5 5.3 8.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Spt20 PF12090.8 CDI82385.1 - 0.00066 19.4 13.7 0.00066 19.4 13.7 4.7 2 1 2 4 4 4 1 Spt20 family RskA PF10099.9 CDI82385.1 - 0.018 15.3 22.3 0.018 15.3 22.3 5.5 1 1 3 5 5 5 0 Anti-sigma-K factor rskA DUF2052 PF09747.9 CDI82385.1 - 0.018 15.1 9.4 0.018 15.1 9.4 3.6 2 1 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) ABC2_membrane_2 PF12679.7 CDI82385.1 - 0.17 11.1 21.6 0.56 9.4 3.1 4.3 3 1 0 3 3 3 0 ABC-2 family transporter protein Spt20 PF12090.8 CDI82387.1 - 0.0013 18.4 30.5 0.0016 18.1 21.0 2.2 2 0 0 2 2 2 1 Spt20 family DUF2722 PF10846.8 CDI82387.1 - 0.004 16.2 15.6 0.004 16.2 15.6 2.5 2 1 0 2 2 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI82387.1 - 0.017 15.2 39.7 0.05 13.6 23.6 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit MecA PF05389.12 CDI82387.1 - 0.08 12.6 0.2 0.08 12.6 0.2 2.0 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) TFB6 PF17110.5 CDI82387.1 - 0.095 12.4 0.6 0.21 11.3 0.6 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH ExsD PF16806.5 CDI82387.1 - 0.31 10.9 14.8 2.5 8.0 0.6 2.3 2 0 0 2 2 2 0 Antiactivator protein ExsD eIF-3_zeta PF05091.12 CDI82387.1 - 0.46 9.4 8.3 0.81 8.6 8.3 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ANAPC_CDC26 PF10471.9 CDI82387.1 - 1.2 10.0 31.3 2.3 9.1 18.5 3.8 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 SR-25 PF10500.9 CDI82387.1 - 1.2 8.7 19.6 5.3 6.6 0.5 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Hep_59 PF07052.11 CDI82387.1 - 1.8 9.4 12.6 0.15 12.8 3.0 2.9 3 0 0 3 3 3 0 Hepatocellular carcinoma-associated antigen 59 SpoIIP PF07454.11 CDI82387.1 - 1.8 7.9 7.5 0.26 10.7 3.2 1.7 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) OmpH PF03938.14 CDI82387.1 - 2.1 8.7 26.3 4.2 7.7 18.2 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Lin-8 PF03353.15 CDI82387.1 - 2.4 7.6 15.0 1.3 8.6 4.9 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Connexin PF00029.19 CDI82387.1 - 4.4 7.0 5.4 1.4 8.6 1.4 2.1 2 1 0 2 2 2 0 Connexin DUF3464 PF11947.8 CDI82387.1 - 4.8 6.9 11.2 2.8 7.7 8.2 2.1 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 CPSF100_C PF13299.6 CDI82387.1 - 5.2 7.2 9.0 0.46 10.6 2.3 2.4 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal BRF1 PF07741.13 CDI82387.1 - 5.9 7.3 9.5 0.45 10.9 3.3 2.3 3 0 0 3 3 2 0 Brf1-like TBP-binding domain Presenilin PF01080.17 CDI82387.1 - 6.7 5.4 14.1 15 4.2 14.2 1.6 1 1 0 1 1 1 0 Presenilin DUF2367 PF10164.9 CDI82387.1 - 8.9 6.9 12.3 1.7 9.2 5.8 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2367) DUF1645 PF07816.11 CDI82387.1 - 9.5 6.8 15.8 7.3 7.1 0.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1645) Spt20 PF12090.8 CDI82392.1 - 0.001 18.8 16.5 0.001 18.8 16.5 6.6 3 2 1 4 4 4 1 Spt20 family DUF2722 PF10846.8 CDI82392.1 - 0.0014 17.7 10.9 0.0014 17.7 10.9 7.2 5 2 1 6 6 6 1 Protein of unknown function (DUF2722) adh_short PF00106.25 CDI82396.1 - 9.8e-46 155.7 5.7 6.9e-45 152.9 5.7 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDI82396.1 - 1.2e-41 142.9 3.3 5.8e-41 140.6 3.3 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.17 CDI82396.1 - 2.1e-32 111.6 0.0 5e-15 55.8 0.0 2.5 2 0 0 2 2 2 2 SCP-2 sterol transfer family KR PF08659.10 CDI82396.1 - 1.1e-15 58.1 1.0 2.1e-15 57.1 1.0 1.5 1 0 0 1 1 1 1 KR domain UPF0564 PF10595.9 CDI82396.1 - 0.027 13.5 3.8 0.041 12.9 3.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 Maf_N PF08383.11 CDI82396.1 - 0.069 12.9 0.0 0.19 11.5 0.0 1.8 1 0 0 1 1 1 0 Maf N-terminal region UPF0564 PF10595.9 CDI82398.1 - 0.00053 19.2 11.4 0.00053 19.2 11.4 10.9 7 3 1 8 8 8 3 Uncharacterised protein family UPF0564 DUF2339 PF10101.9 CDI82398.1 - 0.0034 16.1 0.4 0.0034 16.1 0.4 5.0 3 1 1 4 4 4 1 Predicted membrane protein (DUF2339) DUF1614 PF07758.11 CDI82411.1 - 2.2 8.3 9.1 0.11 12.5 2.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1614) Peptidase_C58 PF03543.14 CDI82411.1 - 2.9 7.6 13.2 4.8 6.8 13.2 1.3 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen Menin PF05053.13 CDI82415.1 - 1.1 7.5 9.0 1.1 7.5 9.0 1.0 1 0 0 1 1 1 0 Menin Ribosomal_60s PF00428.19 CDI82415.1 - 1.4 9.5 23.0 2.6 8.7 23.0 1.6 1 1 0 1 1 1 0 60s Acidic ribosomal protein Coilin_N PF15862.5 CDI82415.1 - 2.3 8.0 10.9 2.6 7.8 10.9 1.1 1 0 0 1 1 1 0 Coilin N-terminus R_equi_Vir PF05526.11 CDI82415.1 - 2.5 7.9 5.0 2.3 8.0 5.0 1.0 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF3138 PF11336.8 CDI82415.1 - 3.1 6.3 9.7 3.1 6.3 9.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Presenilin PF01080.17 CDI82415.1 - 6.1 5.5 6.8 5.9 5.6 6.8 1.0 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CDI82417.1 - 1.9e-05 25.6 8.9 2.6e-05 25.1 8.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) FAM176 PF14851.6 CDI82417.1 - 0.00032 20.4 1.0 0.00035 20.2 1.0 1.1 1 0 0 1 1 1 1 FAM176 family Phage_holin_3_6 PF07332.11 CDI82417.1 - 0.00032 20.7 4.2 0.0004 20.4 4.2 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III Trp_oprn_chp PF09534.10 CDI82417.1 - 0.00052 19.9 11.8 0.00061 19.6 11.8 1.1 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SID-1_RNA_chan PF13965.6 CDI82417.1 - 0.00053 18.5 4.0 0.00053 18.5 4.0 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 OSTbeta PF15048.6 CDI82417.1 - 0.0009 19.4 2.1 0.0011 19.0 2.1 1.2 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein DUF1772 PF08592.11 CDI82417.1 - 0.0011 19.3 0.7 0.0013 19.0 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) DUF3357 PF11837.8 CDI82417.1 - 0.0016 18.9 9.0 0.002 18.6 9.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3357) SARAF PF06682.12 CDI82417.1 - 0.0016 18.2 4.5 0.0017 18.1 4.5 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis SP_C-Propep PF08999.10 CDI82417.1 - 0.0017 18.1 0.2 0.0018 18.0 0.2 1.3 1 0 0 1 1 1 1 Surfactant protein C, N terminal propeptide TMEM51 PF15345.6 CDI82417.1 - 0.0026 17.6 11.7 0.0028 17.6 11.7 1.0 1 0 0 1 1 1 1 Transmembrane protein 51 O-antigen_lig PF13425.6 CDI82417.1 - 0.003 16.4 0.9 0.003 16.4 0.9 1.0 1 0 0 1 1 1 1 O-antigen ligase like membrane protein CBP_BcsG PF11658.8 CDI82417.1 - 0.0036 15.8 10.1 0.0037 15.7 10.1 1.0 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG Connexin PF00029.19 CDI82417.1 - 0.004 16.9 5.9 0.0045 16.8 5.9 1.1 1 0 0 1 1 1 1 Connexin DUF3169 PF11368.8 CDI82417.1 - 0.0041 16.7 1.2 0.0043 16.6 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3169) DUF2371 PF10177.9 CDI82417.1 - 0.0046 17.1 1.2 0.0062 16.7 1.2 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2371) ECSCR PF15820.5 CDI82417.1 - 0.0057 16.5 0.1 0.0064 16.3 0.1 1.2 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator SecY PF00344.20 CDI82417.1 - 0.007 15.7 4.1 0.0072 15.6 4.1 1.1 1 0 0 1 1 1 1 SecY translocase FHIPEP PF00771.20 CDI82417.1 - 0.0081 14.7 8.9 0.0089 14.5 8.9 1.0 1 0 0 1 1 1 1 FHIPEP family ArsP_2 PF11449.8 CDI82417.1 - 0.0084 15.4 6.4 0.0092 15.2 6.4 1.0 1 0 0 1 1 1 1 Putative, 10TM heavy-metal exporter Ctr PF04145.15 CDI82417.1 - 0.0098 16.5 2.9 0.011 16.4 2.9 1.1 1 0 0 1 1 1 1 Ctr copper transporter family MAP17 PF15807.5 CDI82417.1 - 0.0098 16.1 6.0 0.012 15.9 6.0 1.2 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Protocadherin PF08374.11 CDI82417.1 - 0.011 15.8 9.9 0.011 15.8 9.9 1.1 1 0 0 1 1 1 0 Protocadherin CLN3 PF02487.17 CDI82417.1 - 0.011 14.9 3.6 0.011 14.8 3.6 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4446 PF14584.6 CDI82417.1 - 0.012 15.6 3.4 0.015 15.2 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) TMEM208_SND2 PF05620.11 CDI82417.1 - 0.013 15.2 4.6 0.017 14.9 4.6 1.3 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 FPN1 PF06963.12 CDI82417.1 - 0.014 14.0 4.6 0.015 13.9 4.6 1.0 1 0 0 1 1 1 0 Ferroportin1 (FPN1) EphA2_TM PF14575.6 CDI82417.1 - 0.014 16.3 16.5 0.059 14.3 16.5 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MFS_Mycoplasma PF07672.13 CDI82417.1 - 0.014 14.7 1.5 0.018 14.4 1.5 1.3 1 0 0 1 1 1 0 Mycoplasma MFS transporter Bac_export_2 PF01312.19 CDI82417.1 - 0.015 14.6 7.6 0.015 14.5 7.6 1.0 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Nucleoside_tran PF01733.18 CDI82417.1 - 0.02 14.3 2.5 0.021 14.2 2.5 1.0 1 0 0 1 1 1 0 Nucleoside transporter MMM1 PF10296.9 CDI82417.1 - 0.02 13.9 4.8 0.024 13.7 4.8 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 V_ATPase_I PF01496.19 CDI82417.1 - 0.021 12.8 8.1 0.022 12.7 8.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MscL PF01741.18 CDI82417.1 - 0.021 15.1 1.7 0.026 14.8 1.7 1.3 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL DUF898 PF05987.13 CDI82417.1 - 0.022 13.8 0.6 0.024 13.7 0.6 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Ni_hydr_CYTB PF01292.20 CDI82417.1 - 0.025 14.2 0.1 0.029 14.0 0.1 1.2 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 Dpy19 PF10034.9 CDI82417.1 - 0.026 12.8 2.7 0.025 12.8 2.7 1.0 1 0 0 1 1 1 0 Q-cell neuroblast polarisation OATP PF03137.20 CDI82417.1 - 0.031 12.6 2.1 0.035 12.4 2.1 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family TraT PF05818.12 CDI82417.1 - 0.036 13.7 14.9 0.042 13.5 14.9 1.0 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein GRP PF07172.11 CDI82417.1 - 0.038 14.7 1.7 0.054 14.2 1.7 1.3 1 0 0 1 1 1 0 Glycine rich protein family Cadherin_C_2 PF16492.5 CDI82417.1 - 0.04 14.7 2.5 0.056 14.2 2.5 1.2 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal DUF929 PF06053.11 CDI82417.1 - 0.041 13.2 6.1 0.038 13.3 5.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF929) DUF3522 PF12036.8 CDI82417.1 - 0.044 14.1 0.5 0.051 13.9 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3522) LptF_LptG PF03739.14 CDI82417.1 - 0.045 12.6 0.3 0.047 12.5 0.3 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG YfhO PF09586.10 CDI82417.1 - 0.048 11.9 4.4 0.046 12.0 4.4 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO eIF-3_zeta PF05091.12 CDI82417.1 - 0.052 12.5 9.3 0.044 12.8 9.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Serinc PF03348.15 CDI82417.1 - 0.055 12.4 7.0 0.057 12.4 7.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) LRR19-TM PF15176.6 CDI82417.1 - 0.056 13.4 0.5 0.072 13.1 0.5 1.2 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF819 PF05684.12 CDI82417.1 - 0.07 12.2 6.5 0.083 11.9 6.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF819) Herpes_glycop PF01528.16 CDI82417.1 - 0.072 11.9 9.6 0.078 11.8 9.6 1.0 1 0 0 1 1 1 0 Herpesvirus glycoprotein M DcuC PF03606.15 CDI82417.1 - 0.073 11.5 7.3 0.089 11.2 7.3 1.0 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier Acatn PF13000.7 CDI82417.1 - 0.074 11.5 0.7 0.069 11.6 0.7 1.0 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 FA_desaturase PF00487.24 CDI82417.1 - 0.079 12.8 0.0 0.083 12.7 0.0 1.1 1 0 0 1 1 1 0 Fatty acid desaturase EMC3_TMCO1 PF01956.16 CDI82417.1 - 0.092 12.5 6.8 0.11 12.2 6.8 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like 7TM_GPCR_Srx PF10328.9 CDI82417.1 - 0.098 12.3 0.5 0.1 12.2 0.5 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF2232 PF09991.9 CDI82417.1 - 0.11 11.7 6.8 0.12 11.5 6.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DivIC PF04977.15 CDI82417.1 - 0.12 12.2 16.5 0.21 11.4 16.5 1.5 1 0 0 1 1 1 0 Septum formation initiator Flavi_NS4A PF01350.17 CDI82417.1 - 0.12 12.3 5.2 0.17 11.9 5.2 1.4 1 1 0 1 1 1 0 Flavivirus non-structural protein NS4A MFS_1_like PF12832.7 CDI82417.1 - 0.13 11.1 0.4 0.13 11.1 0.4 1.1 1 0 0 1 1 1 0 MFS_1 like family DUF4199 PF13858.6 CDI82417.1 - 0.13 12.6 2.6 0.18 12.2 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Tetraspanin PF00335.20 CDI82417.1 - 0.14 11.9 2.7 0.16 11.6 2.7 1.2 1 0 0 1 1 1 0 Tetraspanin family CcmF_C PF16327.5 CDI82417.1 - 0.14 11.4 4.9 0.15 11.3 4.9 1.1 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal 7tm_1 PF00001.21 CDI82417.1 - 0.16 11.3 2.4 0.19 11.0 2.4 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) NEMP PF10225.9 CDI82417.1 - 0.19 11.4 3.4 0.21 11.2 3.4 1.1 1 0 0 1 1 1 0 NEMP family UPF0239 PF06783.11 CDI82417.1 - 0.19 11.9 6.0 0.26 11.5 6.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) 60KD_IMP PF02096.20 CDI82417.1 - 0.19 11.6 12.0 0.24 11.3 12.0 1.1 1 0 0 1 1 1 0 60Kd inner membrane protein TFB6 PF17110.5 CDI82417.1 - 0.24 11.1 5.4 0.26 11.0 5.4 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Coilin_N PF15862.5 CDI82417.1 - 0.26 11.1 10.5 0.32 10.8 10.5 1.2 1 0 0 1 1 1 0 Coilin N-terminus DDHD PF02862.17 CDI82417.1 - 0.27 11.4 7.1 0.26 11.4 7.1 1.1 1 0 0 1 1 1 0 DDHD domain Mem_trans PF03547.18 CDI82417.1 - 0.35 9.2 3.5 0.36 9.2 3.5 1.1 1 0 0 1 1 1 0 Membrane transport protein CSG2 PF16965.5 CDI82417.1 - 0.37 9.7 3.0 0.42 9.5 3.0 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2298 PF10060.9 CDI82417.1 - 0.37 9.4 6.3 0.41 9.3 6.3 1.0 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) Suf PF05843.14 CDI82417.1 - 0.43 10.5 10.5 0.35 10.8 10.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) HemX PF04375.14 CDI82417.1 - 0.48 9.7 23.5 0.54 9.5 23.5 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase 7TM_GPCR_Srv PF10323.9 CDI82417.1 - 0.67 9.3 5.5 0.86 8.9 5.5 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv G0-G1_switch_2 PF15103.6 CDI82417.1 - 0.95 9.9 11.1 1.2 9.6 10.8 1.3 1 1 0 1 1 1 0 G0/G1 switch protein 2 MLANA PF14991.6 CDI82417.1 - 1.4 9.2 6.5 2 8.7 6.5 1.3 1 1 0 1 1 1 0 Protein melan-A TERB2 PF15101.6 CDI82417.1 - 1.5 8.8 14.6 1.7 8.6 14.6 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Eapp_C PF10238.9 CDI82417.1 - 2 8.5 14.5 2.3 8.3 14.4 1.2 1 1 0 1 1 1 0 E2F-associated phosphoprotein SHR3_chaperone PF08229.11 CDI82417.1 - 2 7.4 13.8 2.4 7.1 13.8 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 Conotoxin PF02950.17 CDI82417.1 - 2.3 9.3 10.2 7.5 7.6 10.2 1.9 1 1 0 1 1 1 0 Conotoxin DUF4079 PF13301.6 CDI82417.1 - 2.4 8.3 9.5 2 8.6 8.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) DUF2227 PF09988.9 CDI82417.1 - 2.6 7.9 5.9 3.1 7.7 5.5 1.3 1 1 0 1 1 1 0 Uncharacterized metal-binding protein (DUF2227) Spt20 PF12090.8 CDI82417.1 - 2.6 7.6 31.6 3 7.4 31.6 1.1 1 0 0 1 1 1 0 Spt20 family WBP-1 PF11669.8 CDI82417.1 - 2.9 8.6 8.4 5.6 7.6 8.4 1.5 1 1 0 1 1 1 0 WW domain-binding protein 1 FliP PF00813.20 CDI82417.1 - 3 7.7 7.5 3.3 7.5 7.5 1.1 1 0 0 1 1 1 0 FliP family HA2 PF04408.23 CDI82417.1 - 3.1 8.1 9.1 4.1 7.7 9.1 1.3 1 1 0 1 1 1 0 Helicase associated domain (HA2) TMEM154 PF15102.6 CDI82417.1 - 3.2 7.6 7.8 6.4 6.7 7.8 1.6 1 1 0 1 1 1 0 TMEM154 protein family RskA PF10099.9 CDI82417.1 - 5.3 7.3 36.4 27 5.0 36.4 2.0 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Helicase_RecD PF05127.14 CDI82417.1 - 6 6.7 11.4 7.1 6.4 11.4 1.0 1 0 0 1 1 1 0 Helicase SdpI PF13630.6 CDI82417.1 - 6 7.1 5.8 7.2 6.8 5.8 1.1 1 0 0 1 1 1 0 SdpI/YhfL protein family R_equi_Vir PF05526.11 CDI82417.1 - 6.2 6.6 12.3 7.9 6.3 12.3 1.2 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein FAM199X PF15814.5 CDI82417.1 - 6.4 5.7 7.8 8.6 5.3 7.8 1.3 1 0 0 1 1 1 0 Protein family FAM199X Baculo_11_kDa PF06143.11 CDI82417.1 - 6.8 6.3 17.8 92 2.7 17.8 2.3 1 1 0 1 1 1 0 Baculovirus 11 kDa family Med15 PF09606.10 CDI82417.1 - 8.1 5.0 29.9 8 5.0 29.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PPL5 PF18168.1 CDI82418.1 - 0.99 8.6 15.5 1 8.6 15.5 1.0 1 0 0 1 1 1 0 Prim-pol family 5 RPN2_C PF18004.1 CDI82418.1 - 3.1 7.7 25.8 3.2 7.6 25.8 1.0 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF3408 PF11888.8 CDI82418.1 - 3.5 7.8 24.4 4.5 7.4 24.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) GOLD_2 PF13897.6 CDI82418.1 - 4.8 7.7 8.9 5.8 7.4 8.9 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking CobT PF06213.12 CDI82418.1 - 6.1 6.1 37.3 6.5 6.1 37.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT AUX_IAA PF02309.16 CDI82419.1 - 0.16 11.8 36.6 0.048 13.5 4.8 2.4 2 0 0 2 2 2 0 AUX/IAA family Peptidase_M50 PF02163.22 CDI82419.1 - 0.48 9.6 0.9 1.1 8.5 0.9 1.5 1 0 0 1 1 1 0 Peptidase family M50 Spt20 PF12090.8 CDI82420.1 - 0.0013 18.4 28.2 0.0013 18.4 28.2 1.2 1 0 0 1 1 1 1 Spt20 family RskA PF10099.9 CDI82420.1 - 0.0015 18.9 14.1 0.002 18.5 14.1 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI82420.1 - 0.27 11.2 30.4 0.32 10.9 30.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI82420.1 - 0.37 10.7 12.7 0.32 10.9 12.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) eIF-3_zeta PF05091.12 CDI82420.1 - 0.44 9.5 13.2 0.4 9.6 13.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF1980 PF09323.10 CDI82420.1 - 0.48 10.3 4.7 0.46 10.4 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Serinc PF03348.15 CDI82420.1 - 1.2 8.0 4.3 1.3 7.9 4.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Presenilin PF01080.17 CDI82420.1 - 1.4 7.6 12.9 1.5 7.5 12.9 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI82420.1 - 1.8 8.6 5.4 1.7 8.7 5.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TERB2 PF15101.6 CDI82420.1 - 7.7 6.5 18.8 9.7 6.2 18.8 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 MutS_V PF00488.21 CDI82421.1 - 1.1e-28 100.5 0.0 1.1e-28 100.5 0.0 1.9 2 0 0 2 2 2 1 MutS domain V CAC1F_C PF16885.5 CDI82421.1 - 5 6.7 38.0 6.6 6.3 0.7 2.4 2 0 0 2 2 2 0 Voltage-gated calcium channel subunit alpha, C-term NPR3 PF03666.13 CDI82424.1 - 0.85 8.3 5.3 0.89 8.3 5.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ABC_ATPase PF09818.9 CDI82425.1 - 0.24 10.2 0.0 0.27 10.0 0.0 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class DUF5563 PF17718.1 CDI82426.1 - 8.4 5.9 17.0 9.6 5.7 13.7 2.3 2 1 0 2 2 2 0 Family of unknown function (DUF5563) ASC PF00858.24 CDI82445.1 - 0.31 10.0 12.6 4.1 6.2 12.6 2.2 1 1 0 1 1 1 0 Amiloride-sensitive sodium channel Caldesmon PF02029.15 CDI82445.1 - 3 6.5 51.0 0.37 9.5 43.0 2.1 2 0 0 2 2 2 0 Caldesmon Sporozoite_P67 PF05642.11 CDI82447.1 - 5e-06 24.9 0.8 0.065 11.3 0.0 2.7 1 1 0 2 2 2 1 Sporozoite P67 surface antigen DUF2722 PF10846.8 CDI82447.1 - 0.0015 17.6 5.6 0.0015 17.6 5.6 5.4 3 2 2 5 5 5 1 Protein of unknown function (DUF2722) SR-25 PF10500.9 CDI82447.1 - 0.0015 18.2 4.5 0.0015 18.2 4.5 4.0 4 0 0 4 4 4 1 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI82447.1 - 0.0067 16.1 11.9 0.0067 16.1 11.9 5.2 3 2 0 5 5 5 1 Spt20 family EOS1 PF12326.8 CDI82447.1 - 0.23 11.4 0.0 0.23 11.4 0.0 4.0 4 1 0 4 4 4 0 N-glycosylation protein Exonuc_VII_L PF02601.15 CDI82448.1 - 0.26 10.8 0.0 0.26 10.8 0.0 5.2 2 1 2 4 4 4 0 Exonuclease VII, large subunit eIF-3_zeta PF05091.12 CDI82449.1 - 0.0035 16.4 9.0 0.0035 16.4 9.0 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TERB2 PF15101.6 CDI82449.1 - 0.01 15.9 10.9 0.011 15.8 10.9 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Suf PF05843.14 CDI82449.1 - 0.017 15.1 15.0 0.019 15.0 15.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 CDI82449.1 - 0.027 14.5 33.0 0.03 14.3 33.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2828 PF11443.8 CDI82449.1 - 0.027 12.6 5.3 0.029 12.5 5.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) V_ATPase_I PF01496.19 CDI82449.1 - 0.065 11.2 5.6 0.057 11.3 5.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EOS1 PF12326.8 CDI82449.1 - 0.087 12.7 3.1 0.089 12.7 3.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein PAT1 PF09770.9 CDI82449.1 - 0.096 10.9 19.7 0.1 10.9 19.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SpoIIP PF07454.11 CDI82449.1 - 0.12 11.8 9.1 0.15 11.5 9.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DDHD PF02862.17 CDI82449.1 - 0.12 12.5 13.0 0.16 12.1 13.0 1.1 1 0 0 1 1 1 0 DDHD domain Med15 PF09606.10 CDI82449.1 - 0.13 11.0 25.2 0.12 11.0 25.2 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Connexin PF00029.19 CDI82449.1 - 0.15 11.8 5.1 0.16 11.7 5.1 1.1 1 0 0 1 1 1 0 Connexin KASH PF10541.9 CDI82449.1 - 0.19 12.1 0.6 0.26 11.6 0.6 1.3 1 0 0 1 1 1 0 Nuclear envelope localisation domain DUF3408 PF11888.8 CDI82449.1 - 0.21 11.7 11.2 0.27 11.4 11.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Hamartin PF04388.12 CDI82449.1 - 0.22 10.2 15.0 0.24 10.0 15.0 1.0 1 0 0 1 1 1 0 Hamartin protein DcuA_DcuB PF03605.14 CDI82449.1 - 0.23 10.3 1.8 0.24 10.2 1.8 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter AIF_C PF14721.6 CDI82449.1 - 0.27 11.6 8.4 0.37 11.1 8.4 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FAM199X PF15814.5 CDI82449.1 - 0.27 10.2 8.6 0.29 10.2 8.6 1.2 1 0 0 1 1 1 0 Protein family FAM199X Serinc PF03348.15 CDI82449.1 - 0.34 9.8 5.1 0.37 9.7 5.1 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) UPF0560 PF10577.9 CDI82449.1 - 0.35 9.3 15.3 0.35 9.3 15.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Neur_chan_memb PF02932.16 CDI82449.1 - 0.48 10.4 8.2 0.54 10.3 8.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI82449.1 - 0.51 9.1 14.2 0.54 9.0 14.2 1.1 1 0 0 1 1 1 0 Presenilin Velvet PF11754.8 CDI82449.1 - 0.57 10.1 12.2 0.63 9.9 12.2 1.1 1 0 0 1 1 1 0 Velvet factor DUF4407 PF14362.6 CDI82449.1 - 0.59 9.4 15.5 0.71 9.2 15.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.12 CDI82449.1 - 0.61 9.9 11.3 0.67 9.7 11.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Folate_carrier PF01770.18 CDI82449.1 - 0.81 8.4 3.5 0.77 8.4 3.5 1.1 1 0 0 1 1 1 0 Reduced folate carrier R_equi_Vir PF05526.11 CDI82449.1 - 1.3 8.9 10.2 1.8 8.4 10.2 1.2 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein ALMT PF11744.8 CDI82449.1 - 1.8 7.3 5.5 1.8 7.3 5.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Band_3_cyto PF07565.13 CDI82449.1 - 2.2 8.0 10.8 2.9 7.6 10.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Coilin_N PF15862.5 CDI82449.1 - 2.6 7.9 14.9 3.9 7.3 14.9 1.3 1 0 0 1 1 1 0 Coilin N-terminus G0-G1_switch_2 PF15103.6 CDI82449.1 - 2.6 8.5 9.5 3.6 8.0 9.5 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 DUF1980 PF09323.10 CDI82449.1 - 2.9 7.8 7.4 3.6 7.4 7.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) RskA PF10099.9 CDI82449.1 - 3 8.1 23.2 0.19 12.0 18.2 1.5 2 0 0 2 2 1 0 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI82449.1 - 3.3 8.7 16.3 7.1 7.7 16.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2722 PF10846.8 CDI82449.1 - 3.6 6.4 32.7 5.9 5.7 32.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) EIIBC-GUT_N PF03612.14 CDI82449.1 - 3.7 7.3 11.3 4.6 7.0 11.3 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Baculo_PP31 PF05311.11 CDI82449.1 - 4.2 6.8 11.2 4.8 6.6 11.2 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) eIF3_subunit PF08597.10 CDI82449.1 - 5.5 6.8 18.9 7.1 6.5 18.9 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit GREB1 PF15782.5 CDI82449.1 - 6.4 3.8 14.5 6.8 3.7 14.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 CDI82449.1 - 6.4 4.8 12.6 6.3 4.8 12.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CSG2 PF16965.5 CDI82449.1 - 6.8 5.5 5.6 8.2 5.3 5.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Ureide_permease PF07168.11 CDI82449.1 - 7.4 5.2 6.2 9 4.9 6.2 1.1 1 0 0 1 1 1 0 Ureide permease Folliculin PF11704.8 CDI82449.1 - 7.5 6.4 12.2 9 6.1 12.2 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF4770 PF15994.5 CDI82449.1 - 7.5 6.7 14.6 11 6.2 14.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Peptidase_S15 PF02129.18 CDI82449.1 - 8.3 5.9 14.4 2.1 7.9 11.8 1.3 2 0 0 2 2 1 0 X-Pro dipeptidyl-peptidase (S15 family) Med15 PF09606.10 CDI82464.1 - 0.4 9.3 37.0 0.49 9.0 37.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.8 CDI82464.1 - 9.4 5.8 27.2 0.58 9.7 2.6 2.9 3 0 0 3 3 3 0 Spt20 family PPP4R2 PF09184.11 CDI82465.1 - 0.0079 15.8 8.0 0.0079 15.8 8.0 1.0 1 0 0 1 1 1 1 PPP4R2 CCSAP PF15748.5 CDI82465.1 - 0.094 12.9 23.0 0.1 12.8 23.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Neur_chan_memb PF02932.16 CDI82465.1 - 0.16 12.0 15.1 0.15 12.1 15.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TCP PF03634.13 CDI82465.1 - 0.18 12.4 20.0 0.21 12.2 20.0 1.1 1 0 0 1 1 1 0 TCP family transcription factor Endostatin PF06482.11 CDI82465.1 - 0.26 10.7 20.0 0.27 10.7 20.0 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin AUX_IAA PF02309.16 CDI82465.1 - 0.36 10.6 12.5 0.39 10.5 12.5 1.1 1 0 0 1 1 1 0 AUX/IAA family CSRNP_N PF16019.5 CDI82465.1 - 0.51 10.2 23.0 0.66 9.8 23.0 1.0 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus PAT1 PF09770.9 CDI82465.1 - 0.8 7.9 38.6 0.8 7.9 38.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 CDI82465.1 - 1 9.3 56.7 1.5 8.8 56.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med19 PF10278.9 CDI82465.1 - 1.4 8.8 15.2 1.7 8.6 15.2 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 SID-1_RNA_chan PF13965.6 CDI82465.1 - 2.4 6.5 11.3 2.4 6.5 11.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RR_TM4-6 PF06459.12 CDI82465.1 - 2.6 7.8 27.0 2.9 7.7 27.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.8 CDI82465.1 - 2.7 6.7 22.5 3.1 6.5 22.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DDHD PF02862.17 CDI82465.1 - 3 8.0 21.5 4.2 7.5 21.5 1.2 1 0 0 1 1 1 0 DDHD domain DUF913 PF06025.12 CDI82465.1 - 4.2 6.3 16.3 4.3 6.2 16.3 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Velvet PF11754.8 CDI82465.1 - 4.7 7.1 23.5 5.3 6.9 23.5 1.1 1 0 0 1 1 1 0 Velvet factor VIR_N PF15912.5 CDI82465.1 - 6.8 6.2 22.2 9.1 5.8 22.2 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Presenilin PF01080.17 CDI82465.1 - 8 5.1 33.5 9.1 4.9 33.5 1.0 1 0 0 1 1 1 0 Presenilin Presenilin PF01080.17 CDI82473.1 - 8.5 5.0 50.3 8.9 5.0 50.3 1.0 1 0 0 1 1 1 0 Presenilin Peptidase_M50 PF02163.22 CDI82475.1 - 0.00078 18.8 0.1 0.13 11.5 0.7 2.3 2 1 0 2 2 2 2 Peptidase family M50 TrbL PF04610.14 CDI82475.1 - 0.018 14.8 0.6 0.018 14.8 0.6 2.5 2 0 0 2 2 2 0 TrbL/VirB6 plasmid conjugal transfer protein DUF2207 PF09972.9 CDI82475.1 - 0.018 13.8 1.7 0.74 8.5 0.0 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) FA_desaturase PF00487.24 CDI82475.1 - 0.053 13.3 8.4 0.17 11.7 0.1 2.3 2 0 0 2 2 2 0 Fatty acid desaturase Wzy_C PF04932.15 CDI82475.1 - 0.055 13.1 0.1 4.2 7.0 0.0 2.5 2 0 0 2 2 2 0 O-Antigen ligase PsbW PF07123.12 CDI82476.1 - 0.7 9.9 1.8 0.76 9.8 1.0 1.6 1 1 0 1 1 1 0 Photosystem II reaction centre W protein (PsbW) HSP70 PF00012.20 CDI82476.1 - 3 5.9 21.7 3.4 5.7 21.7 1.0 1 0 0 1 1 1 0 Hsp70 protein Caldesmon PF02029.15 CDI82476.1 - 3.1 6.5 36.6 3.8 6.2 36.6 1.1 1 0 0 1 1 1 0 Caldesmon DUF2076 PF09849.9 CDI82479.1 - 0.00035 20.7 8.7 0.0004 20.5 8.7 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) E2F_CC-MB PF16421.5 CDI82479.1 - 0.014 15.7 1.7 0.014 15.7 1.7 1.5 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain Fe_bilin_red PF05996.12 CDI82479.1 - 0.024 14.3 1.2 0.027 14.1 1.2 1.2 1 0 0 1 1 1 0 Ferredoxin-dependent bilin reductase DUF4407 PF14362.6 CDI82479.1 - 0.095 12.0 6.1 0.095 12.0 6.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5082 PF16888.5 CDI82479.1 - 0.1 12.9 8.8 0.14 12.5 8.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) OmpH PF03938.14 CDI82479.1 - 0.19 12.0 16.8 0.22 11.8 16.8 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF16 PF01519.16 CDI82479.1 - 0.2 12.2 10.0 0.26 11.8 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF16 Phage_GPO PF05929.11 CDI82479.1 - 0.21 11.2 6.3 0.26 10.9 6.3 1.0 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase NPV_P10 PF05531.12 CDI82479.1 - 0.23 12.0 6.0 0.28 11.7 5.7 1.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein 5_nucleotid PF05761.14 CDI82479.1 - 1.7 7.4 4.9 2 7.2 4.9 1.0 1 0 0 1 1 1 0 5' nucleotidase family ZapB PF06005.12 CDI82479.1 - 2.1 8.8 20.5 36 4.9 20.5 2.0 1 1 0 1 1 1 0 Cell division protein ZapB DDRGK PF09756.9 CDI82480.1 - 0.0053 16.4 10.9 0.0053 16.4 10.9 2.2 2 0 0 2 2 2 1 DDRGK domain SDA1 PF05285.12 CDI82480.1 - 2.7 7.4 30.2 3.2 7.1 30.2 1.1 1 0 0 1 1 1 0 SDA1 Spt20 PF12090.8 CDI82482.1 - 0.005 16.5 7.2 0.005 16.5 7.2 2.6 2 1 1 3 3 3 1 Spt20 family DUF2722 PF10846.8 CDI82485.1 - 0.006 15.6 12.2 0.006 15.6 12.2 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI82485.1 - 0.023 14.7 28.4 0.012 15.6 17.5 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Tim54 PF11711.8 CDI82485.1 - 0.063 12.1 2.0 0.12 11.2 2.0 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 MPM1 PF17234.2 CDI82485.1 - 0.091 13.0 9.1 0.17 12.1 9.1 1.4 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Baculo_PP31 PF05311.11 CDI82485.1 - 0.15 11.6 5.1 27 4.1 7.1 2.3 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Agouti PF05039.12 CDI82485.1 - 0.81 10.4 11.5 0.77 10.5 7.8 2.7 2 0 0 2 2 2 0 Agouti protein Presenilin PF01080.17 CDI82485.1 - 3 6.5 7.1 0.095 11.5 1.0 1.5 2 0 0 2 2 2 0 Presenilin TERB2 PF15101.6 CDI82485.1 - 8.1 6.4 14.7 0.72 9.9 9.7 1.8 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF1980 PF09323.10 CDI82485.1 - 8.6 6.2 11.0 2.4 8.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Yae1_N PF09811.9 CDI82488.1 - 0.0033 17.1 15.0 1.6 8.5 3.8 4.7 2 2 1 3 3 3 3 Essential protein Yae1, N terminal Rrn6 PF10214.9 CDI82491.1 - 0.002 16.7 2.7 0.0022 16.6 2.7 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor SUIM_assoc PF16619.5 CDI82491.1 - 0.0023 18.0 1.1 0.0023 18.0 1.1 1.9 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 RE_XamI PF09572.10 CDI82491.1 - 0.057 13.1 0.0 0.057 13.1 0.0 1.7 2 0 0 2 2 2 0 XamI restriction endonuclease DUF3995 PF13160.6 CDI82491.1 - 0.069 13.5 9.5 2 8.8 3.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3995) ComA PF02679.15 CDI82491.1 - 0.12 11.8 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 (2R)-phospho-3-sulfolactate synthase (ComA) SR-25 PF10500.9 CDI82491.1 - 0.24 11.0 17.1 0.18 11.4 13.9 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Roughex PF06020.11 CDI82491.1 - 0.35 9.9 1.7 0.53 9.3 1.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Ldh_1_C PF02866.18 CDI82491.1 - 3.5 7.5 7.7 0.7 9.8 0.7 2.2 2 0 0 2 2 2 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain ASFV_J13L PF05568.11 CDI82491.1 - 5.9 6.6 13.6 1.2 8.8 1.0 2.4 2 0 0 2 2 2 0 African swine fever virus J13L protein Ribosomal_60s PF00428.19 CDI82491.1 - 9.7 6.9 35.4 9.3 6.9 16.5 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Pex14_N PF04695.13 CDI82492.1 - 0.54 10.9 7.6 1.1 9.9 7.6 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Tic110 PF16940.5 CDI82492.1 - 0.57 8.6 4.7 0.7 8.3 4.7 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter FSA_C PF10479.9 CDI82492.1 - 5.3 5.0 7.3 6.8 4.7 7.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Activator_LAG-3 PF11498.8 CDI82494.1 - 1e-05 24.7 64.8 0.00018 20.6 42.6 2.8 2 0 0 2 2 2 2 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI82494.1 - 0.0008 19.1 9.0 0.0008 19.1 9.0 5.1 2 1 1 3 3 3 1 Spt20 family DUF2722 PF10846.8 CDI82494.1 - 0.00098 18.2 3.4 0.00098 18.2 3.4 4.6 2 1 1 4 4 4 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI82498.1 - 0.0048 17.2 23.4 0.0048 17.2 23.4 9.9 2 2 6 8 8 8 1 Anti-sigma-K factor rskA MecA PF05389.12 CDI82498.1 - 0.013 15.2 1.2 0.061 12.9 1.2 2.2 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) SpoIIP PF07454.11 CDI82498.1 - 0.3 10.5 7.5 0.82 9.1 7.5 1.7 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) AIP3 PF03915.13 CDI82498.1 - 3.5 6.6 19.8 0.14 11.2 12.1 2.1 2 0 0 2 2 2 0 Actin interacting protein 3 Presenilin PF01080.17 CDI82500.1 - 0.24 10.1 21.8 0.27 10.0 21.8 1.0 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 CDI82500.1 - 0.35 10.3 19.8 0.33 10.4 19.8 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RBM39linker PF15519.6 CDI82500.1 - 0.47 11.6 17.5 0.51 11.4 17.5 1.1 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein AXIN1_TNKS_BD PF16646.5 CDI82500.1 - 0.53 11.3 7.0 1.3 10.0 7.0 1.6 1 1 0 1 1 1 0 Axin-1 tankyrase binding domain DUF1644 PF07800.12 CDI82500.1 - 0.73 9.9 14.5 0.81 9.7 14.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1644) DUF3807 PF12720.7 CDI82500.1 - 1.2 9.4 24.1 1.2 9.4 24.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) MMU163 PF17119.5 CDI82500.1 - 1.2 8.2 9.0 1.2 8.3 9.0 1.0 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis BRF1 PF07741.13 CDI82500.1 - 1.8 8.9 14.5 2.3 8.6 14.5 1.3 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DUF1764 PF08576.10 CDI82500.1 - 1.9 9.4 15.6 2 9.3 15.6 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Afi1 PF07792.12 CDI82500.1 - 2.2 8.8 17.3 2.1 8.8 17.3 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Band_3_cyto PF07565.13 CDI82500.1 - 2.2 8.0 18.3 2.4 7.9 18.3 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF5308 PF17233.2 CDI82500.1 - 2.5 8.3 15.2 2.5 8.3 15.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) AIF_C PF14721.6 CDI82500.1 - 2.5 8.5 15.7 2.7 8.4 15.7 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FYDLN_acid PF09538.10 CDI82500.1 - 2.6 8.8 14.0 3 8.6 14.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF3464 PF11947.8 CDI82500.1 - 3.1 7.5 19.4 3.2 7.5 19.4 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 NARP1 PF12569.8 CDI82500.1 - 3.1 6.6 20.2 3.2 6.5 20.2 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Sec62 PF03839.16 CDI82500.1 - 3.3 7.1 14.6 3.4 7.1 14.6 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 Connexin PF00029.19 CDI82500.1 - 3.5 7.3 16.7 3.4 7.4 16.7 1.0 1 0 0 1 1 1 0 Connexin Pal1 PF08316.11 CDI82500.1 - 3.7 8.3 12.3 4.1 8.2 12.3 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein MPM1 PF17234.2 CDI82500.1 - 3.7 7.8 21.4 5 7.3 21.4 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Peptidase_S49_N PF08496.10 CDI82500.1 - 3.8 7.6 17.1 3.9 7.5 17.1 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Eapp_C PF10238.9 CDI82500.1 - 4.2 7.5 20.8 4.5 7.3 20.8 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein GramPos_pilinD1 PF16555.5 CDI82500.1 - 4.6 7.4 12.5 4.9 7.3 12.5 1.0 1 0 0 1 1 1 0 Gram-positive pilin subunit D1, N-terminal domain Slu7 PF11708.8 CDI82500.1 - 4.6 6.9 21.6 4.8 6.8 21.6 1.0 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor GNAT_acetyltr_2 PF13718.6 CDI82500.1 - 4.9 6.5 14.2 5 6.4 14.2 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 FAM91_C PF14648.6 CDI82500.1 - 5.4 5.7 14.5 5.8 5.6 14.5 1.0 1 0 0 1 1 1 0 FAM91 C-terminus PPL5 PF18168.1 CDI82500.1 - 5.6 6.2 15.4 5.8 6.1 15.4 1.0 1 0 0 1 1 1 0 Prim-pol family 5 Gti1_Pac2 PF09729.9 CDI82500.1 - 5.8 7.0 16.2 5.8 7.0 16.2 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family FAM176 PF14851.6 CDI82500.1 - 6 6.5 13.7 6.2 6.5 13.7 1.1 1 0 0 1 1 1 0 FAM176 family CCDC53 PF10152.9 CDI82500.1 - 6.1 7.2 20.8 6.5 7.2 20.8 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF4638 PF15472.6 CDI82500.1 - 6.5 6.4 16.6 6.3 6.5 16.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF4746 PF15928.5 CDI82500.1 - 6.6 6.1 17.0 6.9 6.0 17.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF3381 PF11861.8 CDI82500.1 - 6.6 6.5 22.2 8.4 6.2 22.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) NPR3 PF03666.13 CDI82500.1 - 7 5.3 17.2 6.8 5.4 17.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3402 PF11882.8 CDI82500.1 - 7 5.6 18.4 7 5.6 18.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) DDHD PF02862.17 CDI82500.1 - 7.2 6.7 19.3 7.2 6.7 19.3 1.0 1 0 0 1 1 1 0 DDHD domain CTU2 PF10288.9 CDI82500.1 - 7.8 6.8 19.7 10 6.4 19.7 1.2 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 CPSF100_C PF13299.6 CDI82500.1 - 8.3 6.6 17.8 8.4 6.5 17.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Rxt3 PF08642.10 CDI82500.1 - 8.6 7.2 13.3 9.8 7.0 13.3 1.1 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Baculo_PP31 PF05311.11 CDI82500.1 - 9.2 5.7 21.3 10 5.5 21.3 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Pannexin_like PF12534.8 CDI82500.1 - 9.2 5.2 14.5 8.9 5.3 14.5 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 FAM60A PF15396.6 CDI82500.1 - 9.3 6.2 15.8 9.7 6.1 15.8 1.0 1 0 0 1 1 1 0 Protein Family FAM60A ATAD4 PF15321.6 CDI82500.1 - 9.3 7.7 13.9 11 7.5 13.9 1.2 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 SR-25 PF10500.9 CDI82501.1 - 0.014 15.1 9.9 0.014 15.1 9.9 5.0 5 1 0 5 5 5 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 CDI82503.1 - 2.1e-05 23.5 24.7 2.7e-05 23.1 24.7 1.1 1 0 0 1 1 1 1 Presenilin SR-25 PF10500.9 CDI82503.1 - 0.00034 20.3 10.0 0.00034 20.3 10.0 2.0 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein EPL1 PF10513.9 CDI82503.1 - 0.0018 18.7 11.6 0.0018 18.7 11.6 2.1 2 0 0 2 2 2 1 Enhancer of polycomb-like AAA_11 PF13086.6 CDI82503.1 - 0.0085 15.9 22.1 0.011 15.6 22.1 1.1 1 0 0 1 1 1 1 AAA domain Eapp_C PF10238.9 CDI82503.1 - 0.015 15.4 28.0 0.044 13.9 12.2 2.0 2 0 0 2 2 2 0 E2F-associated phosphoprotein Dsh_C PF12316.8 CDI82503.1 - 0.021 15.2 6.5 0.021 15.2 6.5 2.0 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Peroxin-13_N PF04088.13 CDI82503.1 - 0.027 14.8 22.6 0.14 12.4 5.3 2.1 2 0 0 2 2 2 0 Peroxin 13, N-terminal region FAM176 PF14851.6 CDI82503.1 - 0.037 13.7 17.9 0.54 9.9 1.4 2.1 2 0 0 2 2 2 0 FAM176 family CPSF100_C PF13299.6 CDI82503.1 - 0.044 14.0 21.5 0.11 12.7 8.9 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal TCP PF03634.13 CDI82503.1 - 0.054 14.1 28.1 0.7 10.4 15.5 2.1 2 0 0 2 2 2 0 TCP family transcription factor DUF4834 PF16118.5 CDI82503.1 - 0.06 14.3 8.9 0.06 14.3 8.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) XRN_M PF17846.1 CDI82503.1 - 0.11 11.5 17.7 0.14 11.0 17.7 1.1 1 0 0 1 1 1 0 Xrn1 helical domain DUF3408 PF11888.8 CDI82503.1 - 0.26 11.4 28.9 0.91 9.7 14.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) TRAP_alpha PF03896.16 CDI82503.1 - 0.27 10.4 13.4 0.61 9.2 5.3 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit OAD_gamma PF04277.13 CDI82503.1 - 0.32 11.6 6.5 3.2 8.4 0.0 2.5 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain G0-G1_switch_2 PF15103.6 CDI82503.1 - 0.32 11.5 23.4 1.6 9.2 4.0 2.1 2 0 0 2 2 2 0 G0/G1 switch protein 2 FYDLN_acid PF09538.10 CDI82503.1 - 0.34 11.6 15.2 2.6 8.8 7.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) D123 PF07065.14 CDI82503.1 - 0.41 9.7 19.2 0.77 8.9 2.0 2.0 2 0 0 2 2 2 0 D123 SARAF PF06682.12 CDI82503.1 - 0.42 10.2 22.4 0.93 9.1 22.4 1.6 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis V_ATPase_I PF01496.19 CDI82503.1 - 0.44 8.4 34.2 0.23 9.4 9.8 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Isy1 PF06246.12 CDI82503.1 - 0.45 10.0 25.1 0.49 9.9 10.7 2.0 2 0 0 2 2 2 0 Isy1-like splicing family Afi1 PF07792.12 CDI82503.1 - 0.49 10.9 27.4 1.2 9.6 5.1 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking SID-1_RNA_chan PF13965.6 CDI82503.1 - 0.51 8.7 17.6 0.42 9.0 1.5 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Peptidase_S49_N PF08496.10 CDI82503.1 - 0.53 10.3 28.1 2 8.5 6.9 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Rpp20 PF12328.8 CDI82503.1 - 0.87 9.5 31.1 0.65 10.0 7.2 2.1 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P CBP_BcsG PF11658.8 CDI82503.1 - 0.88 7.9 25.3 0.87 7.9 6.4 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG O-antigen_lig PF13425.6 CDI82503.1 - 0.89 8.3 13.3 1.4 7.6 6.2 2.0 2 0 0 2 2 2 0 O-antigen ligase like membrane protein HA2 PF04408.23 CDI82503.1 - 0.93 9.8 17.3 2 8.7 6.7 2.2 2 0 0 2 2 2 0 Helicase associated domain (HA2) ASC PF00858.24 CDI82503.1 - 0.96 8.3 14.2 1.3 7.9 14.2 1.2 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel DcuA_DcuB PF03605.14 CDI82503.1 - 1.1 8.1 13.0 1.3 7.8 4.0 2.0 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter DUF4820 PF16091.5 CDI82503.1 - 1.1 8.5 24.4 2.2 7.6 3.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF5327 PF17261.2 CDI82503.1 - 1.4 9.7 46.5 1.4 9.7 15.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5327) TMEM51 PF15345.6 CDI82503.1 - 1.4 8.7 37.3 0.58 9.9 11.0 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 DUF4598 PF15370.6 CDI82503.1 - 1.5 9.3 22.4 0.5 10.9 2.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4598) AIF_C PF14721.6 CDI82503.1 - 1.8 9.0 26.6 2.1 8.7 12.7 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FPN1 PF06963.12 CDI82503.1 - 1.9 6.9 15.7 0.54 8.8 1.4 2.1 2 0 0 2 2 2 0 Ferroportin1 (FPN1) Serinc PF03348.15 CDI82503.1 - 2.1 7.2 21.1 0.7 8.8 9.8 2.0 2 0 0 2 2 2 0 Serine incorporator (Serinc) Sec62 PF03839.16 CDI82503.1 - 2.2 7.8 22.8 1.3 8.4 9.8 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 Trp_oprn_chp PF09534.10 CDI82503.1 - 2.4 7.9 6.5 4.2 7.1 6.5 1.4 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) CD20 PF04103.15 CDI82503.1 - 2.4 8.2 8.7 6 6.9 0.4 2.3 2 0 0 2 2 2 0 CD20-like family CSG2 PF16965.5 CDI82503.1 - 2.4 7.0 19.4 3.4 6.5 9.8 2.0 2 0 0 2 2 2 0 Ceramide synthase regulator CobT PF06213.12 CDI82503.1 - 2.5 7.4 45.8 0.68 9.3 11.6 2.0 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT MDD_C PF18376.1 CDI82503.1 - 2.8 7.6 13.8 1.3 8.7 3.2 2.2 2 0 0 2 2 2 0 Mevalonate 5-diphosphate decarboxylase C-terminal domain PigN PF04987.14 CDI82503.1 - 3.1 6.5 19.2 0.4 9.5 3.2 2.1 2 0 0 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) PTPRCAP PF15713.5 CDI82503.1 - 3.5 7.9 30.3 0.14 12.5 10.4 2.1 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated eIF-3_zeta PF05091.12 CDI82503.1 - 4.1 6.3 41.9 2.9 6.8 10.9 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PSK PF06404.12 CDI82503.1 - 4.3 8.4 26.0 9.2 7.4 12.2 2.1 2 0 0 2 2 2 0 Phytosulfokine precursor protein (PSK) U1snRNP70_N PF12220.8 CDI82503.1 - 4.7 7.9 28.2 0.87 10.3 4.0 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal AFT PF08731.11 CDI82503.1 - 4.8 7.6 18.7 0.38 11.2 5.3 2.1 2 0 0 2 2 2 0 Transcription factor AFT DUF3807 PF12720.7 CDI82503.1 - 5 7.3 41.5 4.6 7.5 21.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) TRM13 PF05206.14 CDI82503.1 - 5.3 6.5 22.8 4.4 6.8 4.4 2.1 2 0 0 2 2 2 0 Methyltransferase TRM13 ALMT PF11744.8 CDI82503.1 - 5.8 5.6 25.6 1.3 7.7 11.3 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter CDH1_2_SANT_HL1 PF18375.1 CDI82503.1 - 5.9 7.6 23.5 0.32 11.7 3.2 3.1 2 1 1 3 3 3 0 CDH1/2 SANT-Helical linker 1 Usp PF00582.26 CDI82503.1 - 6 7.4 7.2 3.3 8.2 0.4 2.3 2 0 0 2 2 2 0 Universal stress protein family TFB6 PF17110.5 CDI82503.1 - 6.2 6.5 22.4 3 7.6 3.3 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH HNOBA PF07701.14 CDI82503.1 - 6.4 6.1 31.2 4.7 6.6 7.4 2.0 2 0 0 2 2 2 0 Heme NO binding associated Peptidase_S15 PF02129.18 CDI82503.1 - 7 6.2 23.7 0.99 8.9 8.0 2.0 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) FAM76 PF16046.5 CDI82503.1 - 7.5 5.8 33.2 1.9 7.8 14.2 2.0 2 0 0 2 2 2 0 FAM76 protein OSTbeta PF15048.6 CDI82503.1 - 7.7 6.7 15.9 2.6 8.2 2.2 2.1 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein STAC2_u1 PF16664.5 CDI82503.1 - 7.8 7.0 23.9 1.6 9.2 11.5 2.1 2 0 0 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 EnY2 PF10163.9 CDI82504.1 - 2.1e-07 31.2 0.1 3.9e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 Transcription factor e(y)2 Presenilin PF01080.17 CDI82508.1 - 0.00071 18.4 28.6 0.0013 17.6 5.5 2.2 2 0 0 2 2 2 2 Presenilin MID_MedPIWI PF18296.1 CDI82508.1 - 0.00072 19.4 24.0 0.058 13.2 8.8 2.6 2 0 0 2 2 2 2 MID domain of medPIWI Velvet PF11754.8 CDI82508.1 - 0.0038 17.2 7.7 0.0038 17.2 7.7 2.8 2 1 0 2 2 1 1 Velvet factor CCSAP PF15748.5 CDI82508.1 - 0.0056 16.9 37.9 0.034 14.3 14.3 2.2 2 0 0 2 2 2 2 Centriole, cilia and spindle-associated TCP PF03634.13 CDI82508.1 - 0.0085 16.7 9.0 0.0085 16.7 9.0 3.2 2 1 0 2 2 1 1 TCP family transcription factor TMEM51 PF15345.6 CDI82508.1 - 0.0089 15.9 11.3 0.0089 15.9 11.3 3.4 2 1 0 2 2 1 1 Transmembrane protein 51 SART-1 PF03343.13 CDI82508.1 - 0.042 12.4 24.4 0.08 11.5 10.5 2.1 2 0 0 2 2 2 0 SART-1 family Anticodon_1 PF08264.13 CDI82508.1 - 0.057 13.4 0.1 0.17 11.9 0.1 1.7 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA PAT1 PF09770.9 CDI82508.1 - 0.065 11.5 53.4 0.17 10.2 14.7 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Endostatin PF06482.11 CDI82508.1 - 0.11 12.0 26.4 0.54 9.7 6.6 2.3 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin PIP5K PF01504.18 CDI82508.1 - 0.17 11.1 21.6 0.99 8.6 3.9 2.2 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase SLC12 PF03522.15 CDI82508.1 - 0.35 9.8 28.6 0.28 10.1 4.3 2.1 2 0 0 2 2 2 0 Solute carrier family 12 RAP1 PF07218.11 CDI82508.1 - 0.41 8.9 1.0 0.61 8.3 1.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4820 PF16091.5 CDI82508.1 - 0.79 9.1 29.0 2.6 7.4 11.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF4647 PF15504.6 CDI82508.1 - 0.92 8.5 32.4 0.12 11.5 7.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) U1snRNP70_N PF12220.8 CDI82508.1 - 1.6 9.4 25.1 2.6 8.7 0.7 3.4 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal ALMT PF11744.8 CDI82508.1 - 1.8 7.3 23.7 0.83 8.4 2.7 2.3 2 0 0 2 2 2 0 Aluminium activated malate transporter SID-1_RNA_chan PF13965.6 CDI82508.1 - 2.2 6.6 11.1 2.5 6.4 0.3 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF572 PF04502.13 CDI82508.1 - 3.4 7.2 34.3 0.018 14.7 3.6 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF572) PA26 PF04636.13 CDI82508.1 - 3.5 6.5 20.8 0.68 8.8 2.2 2.3 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) V_ATPase_I PF01496.19 CDI82508.1 - 4.1 5.2 31.9 1.4 6.7 8.2 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family LptF_LptG PF03739.14 CDI82508.1 - 5.3 5.8 10.6 0.87 8.4 2.7 2.1 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG TraT PF05818.12 CDI82510.1 - 0.0016 18.2 11.6 0.0016 18.2 11.6 1.9 3 0 0 3 3 3 1 Enterobacterial TraT complement resistance protein Activator_LAG-3 PF11498.8 CDI82510.1 - 0.03 13.3 28.5 0.048 12.6 28.5 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.13 CDI82510.1 - 0.073 13.1 20.9 0.087 12.8 20.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI82510.1 - 0.081 12.9 4.4 0.087 12.8 4.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 CDI82510.1 - 0.085 11.6 1.0 0.086 11.6 1.0 1.1 1 0 0 1 1 1 0 Presenilin DUF2722 PF10846.8 CDI82510.1 - 0.4 9.6 17.1 0.55 9.1 17.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) eIF-3_zeta PF05091.12 CDI82510.1 - 3.3 6.6 8.3 4.2 6.2 8.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Pex14_N PF04695.13 CDI82510.1 - 5.1 7.7 18.6 0.41 11.3 11.4 2.2 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region UPF0560 PF10577.9 CDI82510.1 - 9.2 4.6 10.5 13 4.2 10.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Kelch_2 PF07646.15 CDI82513.1 - 1.4e-05 24.8 0.2 0.0064 16.4 0.0 2.3 1 1 1 2 2 2 2 Kelch motif Kelch_1 PF01344.25 CDI82513.1 - 0.0001 21.8 0.2 0.011 15.3 0.1 2.5 1 1 1 2 2 2 1 Kelch motif Kelch_4 PF13418.6 CDI82513.1 - 0.00063 19.7 0.4 0.21 11.6 0.0 2.3 1 1 1 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI82513.1 - 0.0011 18.9 0.0 0.0027 17.7 0.0 1.7 2 0 0 2 2 1 1 Kelch motif Kelch_6 PF13964.6 CDI82513.1 - 0.0015 18.7 0.1 0.22 11.9 0.0 2.3 1 1 1 2 2 2 1 Kelch motif GREB1 PF15782.5 CDI82513.1 - 0.05 10.8 10.0 0.057 10.6 10.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Kelch_3 PF13415.6 CDI82513.1 - 0.067 13.5 0.1 1.7 9.0 0.0 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain Asp23 PF03780.13 CDI82513.1 - 0.091 13.2 0.1 0.17 12.3 0.1 1.3 1 0 0 1 1 1 0 Asp23 family, cell envelope-related function XRN_M PF17846.1 CDI82513.1 - 0.57 9.1 3.1 0.76 8.7 3.1 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Ndc1_Nup PF09531.10 CDI82513.1 - 1.1 7.8 13.5 1.5 7.4 13.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup VIR_N PF15912.5 CDI82513.1 - 1.7 8.1 7.4 1.2 8.6 5.3 1.8 2 0 0 2 2 2 0 Virilizer, N-terminal FAM60A PF15396.6 CDI82513.1 - 1.8 8.5 4.9 2.8 7.9 4.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A YjbH PF06082.11 CDI82513.1 - 2.6 6.8 8.0 3.3 6.4 8.0 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Senescence_reg PF04520.13 CDI82513.1 - 3.5 8.5 9.8 6.5 7.6 9.8 1.4 1 0 0 1 1 1 0 Senescence regulator Borrelia_P83 PF05262.11 CDI82513.1 - 5.9 5.3 10.9 7.5 4.9 10.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Presenilin PF01080.17 CDI82513.1 - 6.6 5.4 10.2 9.3 4.9 10.2 1.2 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 CDI82513.1 - 8.8 4.5 26.6 11 4.2 26.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AAA_6 PF12774.7 CDI82515.1 - 1.9e-119 398.5 2.1 1.1e-116 389.4 0.6 3.6 2 1 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDI82515.1 - 3.3e-109 365.6 7.1 2e-108 363.0 7.1 2.5 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 CDI82515.1 - 8.5e-93 311.9 0.0 1.7e-83 281.2 0.0 3.0 1 1 1 2 2 2 2 Dynein heavy chain, N-terminal region 1 Dynein_C PF18199.1 CDI82515.1 - 2.7e-76 256.7 0.0 8.1e-76 255.2 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 CDI82515.1 - 1.3e-71 240.3 1.0 5.9e-71 238.1 0.2 2.8 3 0 0 3 3 3 1 ATP-binding dynein motor region AAA_8 PF12780.7 CDI82515.1 - 1.4e-69 234.3 0.0 4.8e-67 226.0 0.0 3.0 3 0 0 3 3 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 CDI82515.1 - 3.6e-60 202.6 0.0 4.2e-46 156.7 0.0 4.8 5 0 0 5 5 5 3 P-loop containing dynein motor region MT PF12777.7 CDI82515.1 - 8e-56 189.5 6.7 1.3e-55 188.9 6.7 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 CDI82515.1 - 9.9e-44 149.0 0.0 2.6e-43 147.7 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 CDI82515.1 - 3.8e-38 130.2 0.2 4.6e-36 123.5 0.0 3.2 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 CDI82515.1 - 6.7e-23 81.2 0.0 3.2e-22 79.0 0.0 2.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 CDI82515.1 - 2.6e-17 62.9 0.1 1.6e-16 60.3 0.1 2.5 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 CDI82515.1 - 4e-13 49.6 0.0 0.0029 17.6 0.0 5.8 5 0 0 5 5 5 3 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDI82515.1 - 5.9e-05 23.4 2.6 1.8 8.8 0.0 5.8 6 0 0 6 6 6 2 AAA domain AAA PF00004.29 CDI82515.1 - 0.00019 21.9 0.2 1.3 9.5 0.0 4.2 5 0 0 5 5 4 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CDI82515.1 - 0.045 13.8 0.0 1.7 8.7 0.0 3.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CDI82515.1 - 0.12 12.8 0.1 44 4.5 0.0 3.4 3 0 0 3 3 3 0 RNA helicase Sec34 PF04136.15 CDI82515.1 - 0.31 10.9 7.2 5.2 6.9 0.4 3.3 2 0 0 2 2 2 0 Sec34-like family VIT1 PF01988.19 CDI82515.1 - 3.7 7.4 7.5 0.64 9.8 2.6 2.3 2 0 0 2 2 2 0 VIT family Spc7 PF08317.11 CDI82515.1 - 3.8 6.3 26.8 1.3 7.8 7.4 3.6 3 0 0 3 3 3 0 Spc7 kinetochore protein HAP1_N PF04849.13 CDI82515.1 - 9 5.4 23.8 0.091 12.0 8.7 3.0 2 0 0 2 2 2 0 HAP1 N-terminal conserved region ZnuA PF01297.17 CDI82517.1 - 0.083 12.3 0.1 1.5 8.2 0.1 3.0 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic Tctex-1 PF03645.13 CDI82518.1 - 2.8e-21 75.7 0.0 3.4e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family NHL PF01436.21 CDI82519.1 - 8.6e-10 38.2 0.7 0.0017 18.3 0.1 4.0 3 0 0 3 3 3 3 NHL repeat DUF3328 PF11807.8 CDI82519.1 - 0.023 14.5 0.0 0.71 9.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) DUF755 PF05501.11 CDI82520.1 - 0.024 14.9 3.1 0.024 14.9 3.1 3.7 2 1 0 2 2 2 0 Domain of unknown function (DUF755) Presenilin PF01080.17 CDI82520.1 - 1.3 7.7 18.9 1.6 7.4 18.9 1.2 1 0 0 1 1 1 0 Presenilin BUD22 PF09073.10 CDI82520.1 - 1.6 8.0 37.5 1.8 7.9 37.5 1.0 1 0 0 1 1 1 0 BUD22 Plasmodium_Vir PF05795.11 CDI82520.1 - 5.6 6.3 20.3 6.6 6.0 20.3 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SOG2 PF10428.9 CDI82520.1 - 6.3 5.9 24.6 6.5 5.8 24.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 CDI82520.1 - 8 6.3 36.0 8.8 6.1 36.0 1.0 1 0 0 1 1 1 0 SPX domain SAPS PF04499.15 CDI82525.1 - 0.018 13.8 14.0 0.023 13.5 14.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Pex14_N PF04695.13 CDI82525.1 - 0.025 15.3 20.7 0.025 15.3 20.7 3.1 2 1 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF913 PF06025.12 CDI82525.1 - 0.028 13.4 7.9 0.044 12.8 7.9 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) V_ATPase_I PF01496.19 CDI82525.1 - 0.066 11.1 24.2 0.09 10.7 24.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4045 PF13254.6 CDI82525.1 - 0.51 9.9 14.5 0.74 9.4 14.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Caldesmon PF02029.15 CDI82525.1 - 0.51 9.0 29.6 0.69 8.6 29.6 1.1 1 0 0 1 1 1 0 Caldesmon Zip PF02535.22 CDI82525.1 - 0.55 9.4 10.6 1 8.5 10.6 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter CDK5_activator PF03261.15 CDI82525.1 - 1.3 8.5 19.3 1.5 8.3 19.3 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF4484 PF14831.6 CDI82525.1 - 1.4 8.9 27.0 2.1 8.3 26.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4484) SART-1 PF03343.13 CDI82525.1 - 1.8 7.1 26.7 2.3 6.7 26.7 1.2 1 0 0 1 1 1 0 SART-1 family CSG2 PF16965.5 CDI82525.1 - 1.9 7.3 12.3 2.9 6.7 12.3 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Hamartin PF04388.12 CDI82525.1 - 8 5.0 23.2 10 4.7 23.2 1.1 1 0 0 1 1 1 0 Hamartin protein SARAF PF06682.12 CDI82525.1 - 9.2 5.8 30.5 35 3.9 29.0 2.0 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis VIT1 PF01988.19 CDI82529.1 - 0.0052 16.7 23.3 0.0078 16.1 23.3 1.2 1 0 0 1 1 1 1 VIT family SID-1_RNA_chan PF13965.6 CDI82529.1 - 0.0075 14.7 16.5 0.01 14.3 16.5 1.2 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Presenilin PF01080.17 CDI82529.1 - 0.0078 15.0 38.5 0.0087 14.9 38.5 1.3 1 0 0 1 1 1 1 Presenilin CDC45 PF02724.14 CDI82529.1 - 0.01 14.2 24.2 0.012 14.0 24.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Lin-8 PF03353.15 CDI82529.1 - 0.02 14.5 36.7 0.022 14.4 36.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RR_TM4-6 PF06459.12 CDI82529.1 - 0.026 14.4 32.1 0.029 14.2 32.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ni_hydr_CYTB PF01292.20 CDI82529.1 - 0.1 12.2 5.6 2.3 7.8 1.1 2.1 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 SLC12 PF03522.15 CDI82529.1 - 0.13 11.3 33.8 0.16 11.0 33.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Cyt_bd_oxida_II PF02322.15 CDI82529.1 - 0.16 11.3 6.7 0.74 9.1 0.6 2.0 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II Caldesmon PF02029.15 CDI82529.1 - 0.19 10.5 31.1 0.2 10.4 31.1 1.1 1 0 0 1 1 1 0 Caldesmon ALMT PF11744.8 CDI82529.1 - 0.19 10.5 27.9 0.21 10.4 27.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM60A PF15396.6 CDI82529.1 - 0.2 11.7 25.1 0.25 11.3 25.1 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Apt1 PF10351.9 CDI82529.1 - 0.21 10.4 19.4 0.21 10.4 19.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain CCSAP PF15748.5 CDI82529.1 - 0.21 11.7 38.2 0.29 11.3 38.2 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Miga PF10265.9 CDI82529.1 - 0.25 10.3 27.0 0.31 10.0 27.0 1.1 1 0 0 1 1 1 0 Mitoguardin Hid1 PF12722.7 CDI82529.1 - 0.51 8.4 34.0 0.54 8.3 34.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein O-antigen_lig PF13425.6 CDI82529.1 - 0.58 8.9 14.0 0.72 8.6 14.0 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PA26 PF04636.13 CDI82529.1 - 0.58 9.0 27.2 0.68 8.8 27.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF2151 PF10221.9 CDI82529.1 - 0.59 8.7 17.5 0.71 8.4 17.5 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Macoilin PF09726.9 CDI82529.1 - 0.65 8.5 33.3 0.82 8.2 33.3 1.1 1 0 0 1 1 1 0 Macoilin family FA_desaturase PF00487.24 CDI82529.1 - 0.71 9.7 3.9 2.3 8.0 0.4 2.1 1 1 0 2 2 2 0 Fatty acid desaturase Draxin PF15550.6 CDI82529.1 - 0.72 9.7 32.5 0.87 9.4 32.5 1.0 1 0 0 1 1 1 0 Draxin SAPS PF04499.15 CDI82529.1 - 0.76 8.5 25.4 0.86 8.3 25.4 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4045 PF13254.6 CDI82529.1 - 0.83 9.2 37.8 1 8.9 37.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PAT1 PF09770.9 CDI82529.1 - 0.86 7.8 61.9 0.94 7.7 61.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 VIR_N PF15912.5 CDI82529.1 - 0.88 9.1 17.5 1.1 8.8 17.5 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal DUF677 PF05055.12 CDI82529.1 - 1 8.2 18.9 0.39 9.6 2.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF677) NPR3 PF03666.13 CDI82529.1 - 1 8.1 31.3 1.3 7.7 31.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PPP4R2 PF09184.11 CDI82529.1 - 1 8.9 17.5 1.2 8.7 17.5 1.2 1 0 0 1 1 1 0 PPP4R2 AF-4 PF05110.13 CDI82529.1 - 1.1 7.3 43.0 1.4 6.9 43.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein HCO3_cotransp PF00955.21 CDI82529.1 - 1.1 8.0 13.6 1.3 7.8 13.6 1.2 1 0 0 1 1 1 0 HCO3- transporter family CDK5_activator PF03261.15 CDI82529.1 - 1.4 8.4 30.2 1.6 8.2 30.2 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein WTX PF09422.10 CDI82529.1 - 1.4 7.9 28.1 1.8 7.6 28.1 1.1 1 0 0 1 1 1 0 WTX protein Membralin PF09746.9 CDI82529.1 - 1.5 7.7 21.3 1.9 7.4 21.3 1.2 1 0 0 1 1 1 0 Tumour-associated protein TT_ORF1 PF02956.14 CDI82529.1 - 1.6 7.3 21.0 2 7.0 21.0 1.2 1 0 0 1 1 1 0 TT viral orf 1 RIFIN PF02009.16 CDI82529.1 - 1.6 8.5 41.8 1.9 8.3 41.8 1.1 1 0 0 1 1 1 0 Rifin FapA PF03961.13 CDI82529.1 - 1.8 7.1 19.4 2 6.9 19.4 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A CRT10 PF08728.10 CDI82529.1 - 2 6.5 17.2 2.2 6.3 17.2 1.0 1 0 0 1 1 1 0 CRT10 Dapper PF15268.6 CDI82529.1 - 2 7.1 39.3 2.1 7.1 39.3 1.1 1 0 0 1 1 1 0 Dapper MAP7 PF05672.11 CDI82529.1 - 2.1 8.0 55.9 0.12 12.0 51.3 1.4 2 0 0 2 2 1 0 MAP7 (E-MAP-115) family SOBP PF15279.6 CDI82529.1 - 2.6 8.6 32.8 3.2 8.3 32.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein SAGA-Tad1 PF12767.7 CDI82529.1 - 2.6 7.7 27.2 3 7.5 27.2 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Hamartin PF04388.12 CDI82529.1 - 3.9 6.0 33.4 4.7 5.8 33.4 1.1 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 CDI82529.1 - 4 4.4 45.5 4.8 4.2 45.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SART-1 PF03343.13 CDI82529.1 - 4.8 5.6 39.1 6 5.3 39.1 1.2 1 0 0 1 1 1 0 SART-1 family Rgp1 PF08737.10 CDI82529.1 - 5.2 6.1 25.9 5.6 6.0 25.9 1.1 1 0 0 1 1 1 0 Rgp1 Raftlin PF15250.6 CDI82529.1 - 6.2 5.5 30.3 6.7 5.3 30.3 1.1 1 0 0 1 1 1 0 Raftlin PCM1_C PF15717.5 CDI82529.1 - 7 5.2 36.4 8.2 5.0 36.4 1.2 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus DDRGK PF09756.9 CDI82529.1 - 7.5 6.1 43.3 14 5.2 43.3 1.5 1 0 0 1 1 1 0 DDRGK domain DUF572 PF04502.13 CDI82529.1 - 8.6 5.9 34.1 10 5.6 34.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) PIG-S PF10510.9 CDI82529.1 - 8.9 5.0 29.6 12 4.6 29.6 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein MAJIN PF15077.6 CDI82529.1 - 9 6.0 24.2 11 5.7 24.2 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein Cellulose_synt PF03552.14 CDI82529.1 - 9.9 4.5 15.4 12 4.2 15.4 1.1 1 0 0 1 1 1 0 Cellulose synthase Sec62 PF03839.16 CDI82529.1 - 9.9 5.6 29.0 14 5.1 29.0 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 TFIIA PF03153.13 CDI82530.1 - 4.5e-06 26.9 39.7 6.1e-06 26.5 39.7 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 CDI82530.1 - 0.00031 19.7 14.7 0.00031 19.7 14.7 1.8 2 0 0 2 2 2 1 Golgi-body localisation protein domain GREB1 PF15782.5 CDI82530.1 - 0.001 16.4 19.4 0.0012 16.1 19.4 1.1 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer Zip PF02535.22 CDI82530.1 - 0.0028 17.0 2.6 0.0033 16.7 2.6 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter SLC12 PF03522.15 CDI82530.1 - 0.0033 16.5 17.6 0.0047 16.0 17.6 1.2 1 0 0 1 1 1 1 Solute carrier family 12 DUF1645 PF07816.11 CDI82530.1 - 0.0039 17.8 19.9 0.0039 17.8 19.9 2.5 3 0 0 3 3 2 1 Protein of unknown function (DUF1645) CLN3 PF02487.17 CDI82530.1 - 0.0044 16.1 6.7 0.0063 15.6 6.7 1.3 1 0 0 1 1 1 1 CLN3 protein PAT1 PF09770.9 CDI82530.1 - 0.0072 14.7 20.5 0.0085 14.4 20.5 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 TFB6 PF17110.5 CDI82530.1 - 0.0099 15.6 4.4 0.0099 15.6 4.4 2.3 2 1 1 3 3 3 1 Subunit 11 of the general transcription factor TFIIH eIF-3_zeta PF05091.12 CDI82530.1 - 0.012 14.7 12.0 0.014 14.4 12.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FHIPEP PF00771.20 CDI82530.1 - 0.014 13.9 1.7 0.017 13.6 1.7 1.2 1 0 0 1 1 1 0 FHIPEP family Utp14 PF04615.13 CDI82530.1 - 0.053 12.1 24.1 0.065 11.8 24.1 1.2 1 0 0 1 1 1 0 Utp14 protein V_ATPase_I PF01496.19 CDI82530.1 - 0.091 10.7 15.7 0.12 10.2 15.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MAT1 PF06391.13 CDI82530.1 - 0.11 12.3 23.1 0.16 11.7 23.1 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Hamartin PF04388.12 CDI82530.1 - 0.11 11.2 14.8 0.12 11.0 14.8 1.1 1 0 0 1 1 1 0 Hamartin protein CytochromB561_N PF09786.9 CDI82530.1 - 0.12 11.3 16.6 0.16 10.9 16.6 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal ALMT PF11744.8 CDI82530.1 - 0.14 11.0 14.3 0.19 10.5 14.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4638 PF15472.6 CDI82530.1 - 0.25 11.0 9.1 0.34 10.6 9.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Selenoprotein_S PF06936.11 CDI82530.1 - 0.28 11.0 15.8 0.74 9.6 15.8 1.7 1 0 0 1 1 1 0 Selenoprotein S (SelS) LCD1 PF09798.9 CDI82530.1 - 0.3 9.6 17.8 0.35 9.3 17.8 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein DUF4647 PF15504.6 CDI82530.1 - 0.38 9.8 18.0 0.51 9.4 18.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) U1snRNP70_N PF12220.8 CDI82530.1 - 0.45 11.2 13.5 0.85 10.3 13.5 1.4 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Hid1 PF12722.7 CDI82530.1 - 0.67 8.0 25.4 0.99 7.5 25.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Mem_trans PF03547.18 CDI82530.1 - 0.69 8.2 10.6 1.1 7.5 10.6 1.4 1 0 0 1 1 1 0 Membrane transport protein Rtf2 PF04641.12 CDI82530.1 - 0.71 9.2 16.8 0.041 13.2 11.0 1.9 2 0 0 2 2 2 0 Rtf2 RING-finger Membralin PF09746.9 CDI82530.1 - 0.79 8.7 11.0 1 8.3 11.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF3807 PF12720.7 CDI82530.1 - 0.79 10.0 27.8 0.078 13.2 21.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Cons_hypoth698 PF03601.14 CDI82530.1 - 0.85 8.4 2.7 12 4.6 0.4 2.5 1 1 1 2 2 2 0 Conserved hypothetical protein 698 ESM4 PF15952.5 CDI82530.1 - 1 9.8 27.2 2.2 8.7 27.2 1.5 1 0 0 1 1 1 0 Enhancer of split M4 family Mcm10 PF09332.11 CDI82530.1 - 1.1 8.7 21.6 1.8 7.9 21.6 1.3 1 0 0 1 1 1 0 Mcm10 replication factor PA26 PF04636.13 CDI82530.1 - 1.1 8.1 10.4 1.5 7.6 10.4 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Peptidase_S64 PF08192.11 CDI82530.1 - 3.3 6.1 29.7 0.0082 14.7 20.3 1.4 2 0 0 2 2 1 0 Peptidase family S64 DUF2151 PF10221.9 CDI82530.1 - 3.7 6.0 13.7 5.2 5.5 13.7 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Peptidase_S15 PF02129.18 CDI82530.1 - 4 6.9 14.4 0.38 10.3 7.2 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DDRGK PF09756.9 CDI82530.1 - 4.2 6.9 22.7 5.6 6.5 22.7 1.1 1 0 0 1 1 1 0 DDRGK domain Macoilin PF09726.9 CDI82530.1 - 5.4 5.5 35.6 0.042 12.4 24.5 2.1 2 0 0 2 2 2 0 Macoilin family Rrn6 PF10214.9 CDI82530.1 - 5.8 5.3 31.9 8.7 4.7 31.9 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor HCO3_cotransp PF00955.21 CDI82530.1 - 6.3 5.5 6.1 8.6 5.1 6.1 1.3 1 0 0 1 1 1 0 HCO3- transporter family Ureide_permease PF07168.11 CDI82530.1 - 6.6 5.4 9.4 0.77 8.4 4.6 1.8 1 1 1 2 2 2 0 Ureide permease RBP_receptor PF14752.6 CDI82530.1 - 6.9 5.1 7.6 9.8 4.6 7.6 1.2 1 0 0 1 1 1 0 Retinol binding protein receptor DUF1676 PF07898.13 CDI82530.1 - 7.6 6.5 7.1 17 5.4 7.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) FAM76 PF16046.5 CDI82530.1 - 8.1 5.7 24.3 14 4.9 24.3 1.3 1 0 0 1 1 1 0 FAM76 protein MCM_bind PF09739.9 CDI82530.1 - 9.1 4.6 21.0 14 4.0 21.0 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor FemAB PF02388.16 CDI82530.1 - 9.7 4.9 16.3 13 4.5 16.3 1.1 1 0 0 1 1 1 0 FemAB family Peptidase_S64 PF08192.11 CDI82536.1 - 0.011 14.3 17.9 0.013 14.1 17.9 1.0 1 0 0 1 1 1 0 Peptidase family S64 CDC45 PF02724.14 CDI82536.1 - 0.016 13.5 16.0 0.016 13.5 16.0 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.6 CDI82536.1 - 0.03 14.3 12.7 0.034 14.1 12.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SMYLE_N PF18615.1 CDI82536.1 - 0.092 12.3 12.6 0.11 12.0 12.6 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Raftlin PF15250.6 CDI82536.1 - 0.13 11.0 16.4 0.14 10.8 16.4 1.0 1 0 0 1 1 1 0 Raftlin PAT1 PF09770.9 CDI82536.1 - 0.13 10.5 35.0 0.14 10.4 35.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 CDI82536.1 - 0.15 10.8 25.5 0.16 10.7 25.5 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI82536.1 - 0.3 10.9 24.0 0.35 10.7 24.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CAC1F_C PF16885.5 CDI82536.1 - 0.47 10.1 15.4 0.56 9.8 15.4 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Hid1 PF12722.7 CDI82536.1 - 0.53 8.4 21.7 0.59 8.2 21.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Gti1_Pac2 PF09729.9 CDI82536.1 - 0.56 10.3 17.1 0.76 9.8 17.1 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family PA26 PF04636.13 CDI82536.1 - 0.66 8.8 14.9 0.7 8.7 14.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CCSAP PF15748.5 CDI82536.1 - 0.98 9.5 27.3 1.1 9.3 27.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 CDI82536.1 - 1 8.3 22.7 1.2 8.1 22.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Otopetrin PF03189.13 CDI82536.1 - 1.2 7.9 9.0 1.5 7.5 9.0 1.2 1 0 0 1 1 1 0 Otopetrin BORG_CEP PF14957.6 CDI82536.1 - 1.9 9.6 17.6 2.6 9.2 17.6 1.2 1 0 0 1 1 1 0 Cdc42 effector Lin-8 PF03353.15 CDI82536.1 - 2.1 7.8 26.5 2.6 7.5 26.5 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4045 PF13254.6 CDI82536.1 - 2.3 7.8 21.5 2.7 7.6 21.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Neur_chan_memb PF02932.16 CDI82536.1 - 3.2 7.7 18.0 3.8 7.5 18.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CLN3 PF02487.17 CDI82536.1 - 3.5 6.6 14.7 5.1 6.0 14.7 1.3 1 0 0 1 1 1 0 CLN3 protein Plasmodium_Vir PF05795.11 CDI82536.1 - 3.6 6.9 12.7 4.5 6.6 12.7 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF913 PF06025.12 CDI82536.1 - 5.7 5.8 14.7 7.3 5.5 14.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) GREB1 PF15782.5 CDI82536.1 - 5.8 3.9 22.3 6.6 3.7 22.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ALMT PF11744.8 CDI82536.1 - 5.9 5.6 17.1 7.2 5.3 17.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SAPS PF04499.15 CDI82536.1 - 6.7 5.4 17.2 7.5 5.2 17.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PNISR PF15996.5 CDI82536.1 - 7.5 6.8 31.5 8.9 6.5 31.5 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Ndc1_Nup PF09531.10 CDI82536.1 - 7.9 5.0 19.7 9.4 4.8 19.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TYW3 PF02676.14 CDI82536.1 - 8 5.8 11.1 9.7 5.5 11.1 1.1 1 0 0 1 1 1 0 Methyltransferase TYW3 NPR3 PF03666.13 CDI82536.1 - 8 5.1 23.1 8.9 5.0 23.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 HemX PF04375.14 CDI82536.1 - 8.1 5.6 40.7 9.8 5.3 40.7 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2828 PF11443.8 CDI82536.1 - 8.6 4.3 19.3 10 4.0 19.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CDK2AP PF09806.9 CDI82536.1 - 8.7 6.3 25.1 11 6.0 25.1 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DUF4050 PF13259.6 CDI82536.1 - 9.2 6.6 19.6 13 6.1 19.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) CCSAP PF15748.5 CDI82539.1 - 0.0064 16.7 72.7 0.48 10.5 8.4 3.2 3 0 0 3 3 3 3 Centriole, cilia and spindle-associated FCSD-flav_bind PF09242.11 CDI82539.1 - 0.11 12.9 0.3 0.11 12.9 0.3 5.2 5 1 1 6 6 6 0 Flavocytochrome c sulphide dehydrogenase, flavin-binding UPF0565 PF10561.9 CDI82539.1 - 4.2 6.5 36.3 0.24 10.5 0.7 3.3 3 0 0 3 3 3 0 Uncharacterised protein family UPF0565 Hamartin PF04388.12 CDI82539.1 - 9.8 4.7 64.4 0.36 9.4 34.3 2.2 2 0 0 2 2 2 0 Hamartin protein DUF3138 PF11336.8 CDI82542.1 - 0.13 10.8 5.9 0.16 10.5 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Miga PF10265.9 CDI82542.1 - 1.2 8.1 11.6 1.7 7.5 11.6 1.3 1 0 0 1 1 1 0 Mitoguardin TraG_N PF07916.11 CDI82542.1 - 3.2 6.5 6.8 3.7 6.3 6.8 1.0 1 0 0 1 1 1 0 TraG-like protein, N-terminal region SKA1 PF07160.12 CDI82542.1 - 5.7 6.7 6.0 52 3.6 6.0 2.0 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF3439 PF11921.8 CDI82546.1 - 0.25 11.3 2.0 0.72 9.8 2.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SUIM_assoc PF16619.5 CDI82546.1 - 8.9 6.5 17.9 5.1 7.2 0.8 3.5 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 YukC PF10140.9 CDI82555.1 - 0.094 11.5 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC DUF966 PF06136.13 CDI82556.1 - 5.1 6.7 6.0 6.6 6.3 6.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF3446 PF11928.8 CDI82559.1 - 0.12 12.7 16.7 0.087 13.1 11.7 2.3 2 0 0 2 2 2 0 Early growth response N-terminal domain SR-25 PF10500.9 CDI82559.1 - 0.24 11.0 13.7 0.072 12.7 10.5 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI82562.1 - 0.0012 17.9 8.0 0.0012 17.9 8.0 7.0 5 2 1 6 6 6 2 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI82562.1 - 0.0031 17.1 13.0 0.0031 17.1 13.0 6.3 5 2 1 6 6 6 2 Spt20 family DUF4834 PF16118.5 CDI82562.1 - 0.031 15.2 0.0 0.031 15.2 0.0 6.5 6 0 0 6 6 6 0 Domain of unknown function (DUF4834) eIF-3_zeta PF05091.12 CDI82562.1 - 0.77 8.7 51.0 0.13 11.3 10.1 4.1 4 0 0 4 4 4 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NPR3 PF03666.13 CDI82564.1 - 0.017 13.9 18.5 0.022 13.6 18.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC12 PF03522.15 CDI82564.1 - 0.04 12.9 23.2 0.043 12.8 23.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 CDI82564.1 - 0.6 8.8 30.8 0.69 8.6 30.8 1.1 1 0 0 1 1 1 0 Presenilin BUD22 PF09073.10 CDI82564.1 - 1 8.6 37.4 1.2 8.4 37.4 1.1 1 0 0 1 1 1 0 BUD22 PA26 PF04636.13 CDI82564.1 - 3.2 6.6 21.8 3.6 6.4 21.8 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Neur_chan_memb PF02932.16 CDI82564.1 - 3.4 7.7 14.0 4.1 7.4 14.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Plasmodium_Vir PF05795.11 CDI82564.1 - 4.6 6.6 22.4 5.6 6.3 22.4 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Suf PF05843.14 CDI82565.1 - 2.2 8.2 23.2 2.4 8.1 23.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) eIF-3_zeta PF05091.12 CDI82565.1 - 2.4 7.1 18.1 2.5 7.0 18.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MgsA_C PF12002.8 CDI82565.1 - 2.4 8.1 12.3 3 7.8 12.3 1.1 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal DDHD PF02862.17 CDI82565.1 - 3 8.0 13.1 3.3 7.8 13.1 1.1 1 0 0 1 1 1 0 DDHD domain Exonuc_VII_L PF02601.15 CDI82565.1 - 5.8 6.4 21.7 6.9 6.1 21.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit FAM60A PF15396.6 CDI82565.1 - 6.3 6.7 11.3 6.7 6.6 11.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Activator_LAG-3 PF11498.8 CDI82565.1 - 8.3 5.2 50.6 10 4.9 50.6 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 V_ATPase_I PF01496.19 CDI82565.1 - 9.4 4.0 13.5 9.7 4.0 13.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GYF PF02213.16 CDI82571.1 - 5e-15 54.9 0.4 1.4e-14 53.4 0.4 1.8 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 CDI82571.1 - 1e-05 25.2 0.2 4.1e-05 23.3 0.2 2.1 1 0 0 1 1 1 1 GYF domain 2 SUIM_assoc PF16619.5 CDI82571.1 - 0.0018 18.3 0.0 0.0018 18.3 0.0 5.8 2 1 1 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 O-antigen_lig PF13425.6 CDI82571.1 - 0.032 13.1 3.7 0.039 12.7 3.7 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4241 PF14025.6 CDI82571.1 - 0.46 10.8 6.7 0.32 11.3 5.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4241) AMP-binding PF00501.28 CDI82571.1 - 0.56 8.7 4.6 0.92 8.0 4.6 1.3 1 0 0 1 1 1 0 AMP-binding enzyme Neuraminidase PF18413.1 CDI82571.1 - 1.1 8.9 14.1 0.32 10.6 9.6 2.1 2 0 0 2 2 2 0 Neuraminidase-like domain STAC2_u1 PF16664.5 CDI82571.1 - 1.1 9.7 11.3 0.81 10.2 8.0 2.0 2 0 0 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 TCP PF03634.13 CDI82571.1 - 4.6 7.8 23.3 1.5 9.3 17.5 2.2 2 0 0 2 2 2 0 TCP family transcription factor Band_3_cyto PF07565.13 CDI82571.1 - 5.8 6.6 21.3 6.8 6.4 16.5 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain WDCP PF15390.6 CDI82573.1 - 1.3 7.3 24.8 1.6 7.0 24.8 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family DUF572 PF04502.13 CDI82573.1 - 4.1 6.9 25.1 5.5 6.5 25.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Ribosomal_60s PF00428.19 CDI82577.1 - 0.006 17.1 3.1 0.0084 16.7 3.1 1.4 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3824 PF12868.7 CDI82577.1 - 0.0095 16.6 7.9 0.0095 16.6 7.9 2.3 2 0 0 2 2 2 1 Domain of unknwon function (DUF3824) RskA PF10099.9 CDI82577.1 - 0.012 16.0 11.2 0.012 16.0 11.2 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Macoilin PF09726.9 CDI82577.1 - 2.5 6.5 31.7 3.1 6.3 31.7 1.1 1 0 0 1 1 1 0 Macoilin family SRP-alpha_N PF04086.13 CDI82577.1 - 5.7 6.8 25.4 6.8 6.5 25.4 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Utp14 PF04615.13 CDI82577.1 - 8.1 4.9 28.4 8.8 4.8 28.4 1.0 1 0 0 1 1 1 0 Utp14 protein RskA PF10099.9 CDI82578.1 - 0.0045 17.3 11.6 0.0054 17.0 11.6 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF908 PF06012.12 CDI82578.1 - 0.013 15.0 5.2 0.014 14.8 5.2 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) RIC3 PF15361.6 CDI82578.1 - 0.23 11.8 3.5 0.22 11.9 2.7 1.4 1 1 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 TFIIA PF03153.13 CDI82578.1 - 8.9 6.2 18.2 10 6.0 18.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI82579.1 - 0.0041 16.8 19.5 0.0045 16.6 19.5 1.1 1 0 0 1 1 1 1 Spt20 family eIF-3_zeta PF05091.12 CDI82579.1 - 0.0041 16.2 3.2 0.0041 16.2 3.2 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4834 PF16118.5 CDI82579.1 - 0.0041 18.0 3.2 0.0058 17.6 3.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Hydin_ADK PF17213.3 CDI82579.1 - 0.0044 17.3 0.4 0.0051 17.1 0.4 1.1 1 0 0 1 1 1 1 Hydin Adenylate kinase-like domain FHIPEP PF00771.20 CDI82579.1 - 0.0048 15.4 2.0 0.0054 15.3 2.0 1.0 1 0 0 1 1 1 1 FHIPEP family RskA PF10099.9 CDI82579.1 - 0.0049 17.2 8.6 0.0058 17.0 8.6 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF5327 PF17261.2 CDI82579.1 - 0.0057 17.4 5.6 0.0078 16.9 5.6 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5327) CPSF100_C PF13299.6 CDI82579.1 - 0.0071 16.6 2.7 0.0078 16.4 2.7 1.1 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal CBP_BcsG PF11658.8 CDI82579.1 - 0.0092 14.4 2.2 0.01 14.3 2.2 1.1 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG DUF2828 PF11443.8 CDI82579.1 - 0.013 13.7 2.2 0.012 13.7 2.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DDHD PF02862.17 CDI82579.1 - 0.013 15.7 1.2 0.013 15.7 1.2 1.1 1 0 0 1 1 1 0 DDHD domain YfhO PF09586.10 CDI82579.1 - 0.017 13.4 0.7 0.022 13.1 0.7 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Suf PF05843.14 CDI82579.1 - 0.019 14.9 3.9 0.019 15.0 3.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 CDI82579.1 - 0.021 13.6 3.1 0.022 13.5 3.1 1.2 1 0 0 1 1 1 0 Presenilin tRNA_synt_1c_R2 PF04557.15 CDI82579.1 - 0.021 15.7 2.1 0.026 15.5 2.1 1.2 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 FAM176 PF14851.6 CDI82579.1 - 0.022 14.4 0.7 0.025 14.2 0.7 1.1 1 0 0 1 1 1 0 FAM176 family TFIIA PF03153.13 CDI82579.1 - 0.024 14.7 15.8 0.026 14.5 15.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 CDI82579.1 - 0.024 12.6 2.4 0.026 12.5 2.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family OATP PF03137.20 CDI82579.1 - 0.025 12.9 0.4 0.027 12.8 0.4 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CLN3 PF02487.17 CDI82579.1 - 0.025 13.6 0.9 0.026 13.6 0.9 1.0 1 0 0 1 1 1 0 CLN3 protein Connexin PF00029.19 CDI82579.1 - 0.033 14.0 1.1 0.037 13.8 1.1 1.1 1 0 0 1 1 1 0 Connexin DUF3357 PF11837.8 CDI82579.1 - 0.037 14.5 0.5 0.05 14.1 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) SET PF00856.28 CDI82579.1 - 0.04 14.3 0.7 0.041 14.3 0.7 1.1 1 0 0 1 1 1 0 SET domain Pex16 PF08610.10 CDI82579.1 - 0.041 13.0 1.0 0.046 12.9 1.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) PH_4 PF15404.6 CDI82579.1 - 0.051 13.4 1.5 0.066 13.0 1.5 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain SpoIIP PF07454.11 CDI82579.1 - 0.053 13.0 3.3 0.056 12.9 3.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) WBP-1 PF11669.8 CDI82579.1 - 0.059 14.0 3.2 0.095 13.3 3.2 1.5 1 1 0 1 1 1 0 WW domain-binding protein 1 SprA-related PF12118.8 CDI82579.1 - 0.061 12.5 13.3 0.074 12.2 13.3 1.1 1 0 0 1 1 1 0 SprA-related family DUF2722 PF10846.8 CDI82579.1 - 0.061 12.3 16.4 0.066 12.1 16.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Baculo_PP31 PF05311.11 CDI82579.1 - 0.064 12.7 4.1 0.072 12.6 4.1 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Chi-conotoxin PF16981.5 CDI82579.1 - 0.066 13.4 1.4 0.2 11.9 1.3 1.8 1 1 1 2 2 2 0 chi-Conotoxin or t superfamily ABC2_membrane_2 PF12679.7 CDI82579.1 - 0.069 12.4 0.2 0.076 12.3 0.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein GBP PF02263.19 CDI82579.1 - 0.073 12.3 1.6 0.74 9.0 0.0 2.0 2 0 0 2 2 2 0 Guanylate-binding protein, N-terminal domain DIM PF08194.12 CDI82579.1 - 0.077 13.2 1.0 0.13 12.5 1.0 1.4 1 0 0 1 1 1 0 DIM protein Conotoxin PF02950.17 CDI82579.1 - 0.078 14.0 6.8 0.15 13.1 6.8 1.5 1 1 0 1 1 1 0 Conotoxin UPF0560 PF10577.9 CDI82579.1 - 0.088 11.3 9.6 0.11 11.0 9.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 SID-1_RNA_chan PF13965.6 CDI82579.1 - 0.093 11.1 0.1 0.1 11.0 0.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TMEM208_SND2 PF05620.11 CDI82579.1 - 0.098 12.4 5.3 0.32 10.8 5.8 1.6 2 0 0 2 2 1 0 SRP-independent targeting protein 2/TMEM208 EPL1 PF10513.9 CDI82579.1 - 0.11 12.9 6.4 0.13 12.6 6.4 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like O-antigen_lig PF13425.6 CDI82579.1 - 0.12 11.1 0.1 0.13 11.1 0.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF3742 PF12553.8 CDI82579.1 - 0.13 12.4 0.1 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) PigN PF04987.14 CDI82579.1 - 0.15 10.9 4.0 0.18 10.6 4.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) MTABC_N PF16185.5 CDI82579.1 - 0.16 11.4 0.4 0.19 11.2 0.4 1.1 1 0 0 1 1 1 0 Mitochondrial ABC-transporter N-terminal five TM region GRP PF07172.11 CDI82579.1 - 0.18 12.5 0.1 0.27 11.9 0.1 1.3 1 0 0 1 1 1 0 Glycine rich protein family Ctr PF04145.15 CDI82579.1 - 0.22 12.2 1.1 0.25 12.0 1.1 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Neur_chan_memb PF02932.16 CDI82579.1 - 0.24 11.4 1.0 0.23 11.5 1.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4770 PF15994.5 CDI82579.1 - 0.27 11.5 6.8 0.3 11.3 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Kei1 PF08552.11 CDI82579.1 - 0.28 11.0 1.3 0.3 10.9 1.3 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Serinc PF03348.15 CDI82579.1 - 0.31 9.9 0.8 0.35 9.8 0.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Trp_oprn_chp PF09534.10 CDI82579.1 - 0.33 10.7 4.5 0.32 10.8 3.4 1.3 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Plasmodium_Vir PF05795.11 CDI82579.1 - 0.35 10.2 1.4 0.34 10.3 1.4 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TERB2 PF15101.6 CDI82579.1 - 0.36 10.9 9.9 0.42 10.6 9.9 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 PepSY_2 PF13670.6 CDI82579.1 - 0.44 10.6 7.5 0.96 9.5 7.5 1.6 1 1 0 1 1 1 0 Peptidase propeptide and YPEB domain Androgen_recep PF02166.16 CDI82579.1 - 0.54 9.0 21.6 0.045 12.6 16.7 1.6 2 0 0 2 2 2 0 Androgen receptor EphA2_TM PF14575.6 CDI82579.1 - 0.65 10.9 2.8 1.1 10.2 2.8 1.5 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain EIIBC-GUT_N PF03612.14 CDI82579.1 - 0.87 9.3 5.1 1.1 9.0 5.1 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Roughex PF06020.11 CDI82579.1 - 1.8 7.6 11.3 2.2 7.3 11.3 1.1 1 0 0 1 1 1 0 Drosophila roughex protein DUF3464 PF11947.8 CDI82579.1 - 2.1 8.1 8.2 2.9 7.6 8.2 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 RBP_receptor PF14752.6 CDI82579.1 - 2.3 6.7 6.6 2.8 6.4 6.6 1.1 1 0 0 1 1 1 0 Retinol binding protein receptor DUF2967 PF11179.8 CDI82579.1 - 2.7 6.0 9.6 3.1 5.8 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Spt20 PF12090.8 CDI82581.1 - 0.00023 20.8 52.6 0.018 14.7 26.1 3.1 3 0 0 3 3 3 3 Spt20 family RskA PF10099.9 CDI82581.1 - 0.00073 19.9 2.2 0.00073 19.9 2.2 4.3 2 1 2 4 4 4 2 Anti-sigma-K factor rskA Zea_mays_MuDR PF05928.11 CDI82581.1 - 0.0044 16.7 1.9 0.0044 16.7 1.9 3.5 4 0 0 4 4 4 1 Zea mays MURB-like protein (MuDR) DUF2722 PF10846.8 CDI82581.1 - 0.13 11.2 41.2 0.74 8.7 21.3 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) MCU PF04678.13 CDI82581.1 - 0.75 9.9 9.8 3.3 7.8 4.8 2.6 2 0 0 2 2 2 0 Mitochondrial calcium uniporter SLC12 PF03522.15 CDI82581.1 - 1.7 7.6 14.8 1.2 8.1 6.5 2.3 2 0 0 2 2 2 0 Solute carrier family 12 DUF2464 PF10240.9 CDI82581.1 - 1.8 8.1 10.8 0.7 9.4 1.4 2.6 2 0 0 2 2 2 0 Multivesicular body subunit 12 XRN_M PF17846.1 CDI82581.1 - 5 6.0 12.4 0.19 10.6 5.4 1.9 2 0 0 2 2 2 0 Xrn1 helical domain DUF2052 PF09747.9 CDI82581.1 - 6.1 6.9 17.0 0.21 11.7 5.9 2.7 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Miga PF10265.9 CDI82581.1 - 8 5.3 19.6 1.6 7.6 7.6 2.2 2 0 0 2 2 2 0 Mitoguardin SR-25 PF10500.9 CDI82588.1 - 0.00097 18.8 27.2 0.0017 18.0 14.0 2.1 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein DUF1980 PF09323.10 CDI82588.1 - 0.0088 16.0 2.0 0.0088 16.0 2.0 2.3 1 1 1 2 2 1 1 Domain of unknown function (DUF1980) IMUP PF15761.5 CDI82588.1 - 0.031 15.0 6.5 0.031 15.0 6.5 2.1 2 0 0 2 2 2 0 Immortalisation up-regulated protein SURF6 PF04935.12 CDI82588.1 - 0.14 12.0 28.1 0.36 10.6 28.0 1.8 1 1 0 1 1 1 0 Surfeit locus protein 6 MecA PF05389.12 CDI82588.1 - 0.28 10.8 16.7 0.66 9.6 8.8 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) Lin-8 PF03353.15 CDI82588.1 - 0.48 9.9 30.3 0.22 11.0 5.9 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist TFIIA PF03153.13 CDI82588.1 - 0.68 9.9 74.1 2 8.3 14.1 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4228 PF14009.6 CDI82588.1 - 2.4 8.5 18.3 1.1 9.6 2.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) FAM176 PF14851.6 CDI82588.1 - 3.5 7.3 16.3 1.8 8.2 5.4 2.3 2 0 0 2 2 2 0 FAM176 family CobT PF06213.12 CDI82588.1 - 3.8 6.8 42.6 2.1 7.7 26.5 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT EIF4E-T PF10477.9 CDI82588.1 - 4.4 6.0 45.4 7.8 5.2 45.4 1.3 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Connexin PF00029.19 CDI82588.1 - 4.5 7.0 16.9 4.9 6.8 9.4 2.1 2 0 0 2 2 2 0 Connexin PIEZO PF15917.5 CDI82588.1 - 4.8 6.6 33.5 0.5 9.8 6.1 2.3 2 0 0 2 2 2 0 Piezo CPSF100_C PF13299.6 CDI82588.1 - 4.9 7.3 23.3 1.6 8.9 12.0 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Mem_trans PF03547.18 CDI82588.1 - 4.9 5.4 14.6 0.055 11.9 3.0 2.0 2 0 0 2 2 2 0 Membrane transport protein MRI PF15325.6 CDI82588.1 - 5.4 8.2 12.5 15 6.8 2.9 2.4 2 0 0 2 2 2 0 Modulator of retrovirus infection Mak16 PF04874.14 CDI82588.1 - 6 7.5 14.5 7.1 7.3 1.2 2.4 2 0 0 2 2 2 0 Mak16 protein C-terminal region tRNA_synt_1c_R2 PF04557.15 CDI82588.1 - 6.2 7.8 16.0 1.7 9.6 6.9 2.5 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DUF3408 PF11888.8 CDI82588.1 - 6.2 7.0 23.5 1.5 8.9 11.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) DUF2052 PF09747.9 CDI82588.1 - 7.4 6.6 27.2 7.1 6.7 3.8 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) FYDLN_acid PF09538.10 CDI82588.1 - 9.3 7.0 13.1 4.5 8.0 4.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) ALMT PF11744.8 CDI82590.1 - 2.6 6.8 39.6 3.8 6.2 39.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Asp-B-Hydro_N PF05279.11 CDI82590.1 - 3.4 7.7 34.1 4 7.4 34.1 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CDC27 PF09507.10 CDI82590.1 - 4 6.7 48.7 5 6.4 48.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PPP4R2 PF09184.11 CDI82590.1 - 5.4 6.5 31.0 7.3 6.1 31.0 1.2 1 0 0 1 1 1 0 PPP4R2 CAC1F_C PF16885.5 CDI82590.1 - 9.4 5.8 34.8 12 5.4 34.8 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Presenilin PF01080.17 CDI82601.1 - 4.1 6.1 13.9 4.5 5.9 13.9 1.1 1 0 0 1 1 1 0 Presenilin eIF_4EBP PF05456.11 CDI82601.1 - 7.5 6.5 11.2 1.2 9.2 5.3 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Pet100 PF09803.9 CDI82601.1 - 7.9 7.1 7.2 27 5.4 5.6 2.4 2 1 0 2 2 2 0 Pet100 RskA PF10099.9 CDI82604.1 - 1.3e-06 28.8 0.4 1.3e-06 28.8 0.4 8.6 3 3 3 6 6 6 3 Anti-sigma-K factor rskA Spore_YhcN_YlaJ PF09580.10 CDI82604.1 - 0.33 11.0 0.0 0.33 11.0 0.0 4.2 3 3 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) zf-C3HC4 PF00097.25 CDI82614.1 - 2.9e-07 30.3 7.7 5.8e-07 29.3 7.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDI82614.1 - 4.9e-06 26.3 7.9 1.2e-05 25.0 7.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDI82614.1 - 2.5e-05 24.3 11.1 4.8e-05 23.4 11.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CDI82614.1 - 8.3e-05 22.5 6.5 0.00019 21.4 6.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDI82614.1 - 0.00013 21.8 7.5 0.00025 20.8 7.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI82614.1 - 0.00055 19.8 8.1 0.0035 17.3 8.5 2.1 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_6 PF14835.6 CDI82614.1 - 0.00057 19.7 3.8 0.0013 18.6 3.8 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 CDI82614.1 - 0.00065 20.0 9.0 0.0013 19.1 9.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-Nse PF11789.8 CDI82614.1 - 0.0022 17.7 3.0 0.0051 16.6 3.0 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Rsbr_N PF08678.10 CDI82614.1 - 0.057 13.5 0.0 0.34 11.0 0.0 1.9 2 0 0 2 2 2 0 Rsbr N terminal Prok-RING_4 PF14447.6 CDI82614.1 - 0.07 13.0 7.4 1.9 8.4 8.1 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 CDI82614.1 - 0.15 12.1 2.9 0.3 11.1 2.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 CDI82614.1 - 1.7 8.5 13.5 15 5.5 13.9 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-H2C2_2 PF13465.6 CDI82614.1 - 1.8 9.1 7.9 2.3 8.8 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger double domain TFIIA PF03153.13 CDI82614.1 - 4.2 7.3 12.7 6.1 6.7 12.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Codanin-1_C PF15296.6 CDI82614.1 - 4.3 7.4 7.2 6.7 6.8 0.1 2.6 2 1 0 2 2 2 0 Codanin-1 C-terminus Rad50_zn_hook PF04423.14 CDI82614.1 - 6.3 6.7 11.5 2.6 8.0 1.3 3.3 3 0 0 3 3 3 0 Rad50 zinc hook motif Dynamitin PF04912.14 CDI82615.1 - 2.5e-16 60.0 0.0 2.7e-16 59.9 0.0 1.0 1 0 0 1 1 1 1 Dynamitin PLU-1 PF08429.11 CDI82615.1 - 0.0085 15.3 0.1 0.012 14.9 0.1 1.2 1 0 0 1 1 1 1 PLU-1-like protein SlyX PF04102.12 CDI82615.1 - 1.9 9.1 5.0 17 6.1 5.0 2.2 1 1 0 1 1 1 0 SlyX Dynamitin PF04912.14 CDI82616.1 - 5.2e-15 55.7 9.2 4.7e-10 39.4 2.9 2.1 2 0 0 2 2 2 2 Dynamitin TRAF_BIRC3_bd PF16673.5 CDI82616.1 - 0.16 11.8 2.0 0.54 10.1 0.6 2.3 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain DUF536 PF04394.14 CDI82616.1 - 0.29 11.0 4.3 3.3 7.7 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF536 Actin PF00022.19 CDI82617.1 - 1.9e-75 254.0 0.0 4.1e-74 249.6 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CDI82617.1 - 1 8.1 2.4 18 4.0 0.0 2.8 3 0 0 3 3 3 0 MreB/Mbl protein 40S_SA_C PF16122.5 CDI82618.1 - 3.1 9.2 12.6 0.74 11.2 5.5 2.7 3 0 0 3 3 3 0 40S ribosomal protein SA C-terminus PNP_UDP_1 PF01048.20 CDI82629.1 - 5.4e-31 107.6 0.0 7.5e-31 107.2 0.0 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily Topoisom_I_N PF02919.15 CDI82631.1 - 0.019 14.5 1.0 0.019 14.5 1.0 5.5 4 2 1 5 5 5 0 Eukaryotic DNA topoisomerase I, DNA binding fragment RskA PF10099.9 CDI82631.1 - 0.24 11.7 0.0 0.24 11.7 0.0 10.5 2 2 5 8 8 8 0 Anti-sigma-K factor rskA KASH PF10541.9 CDI82631.1 - 8.8 6.7 9.1 33 4.9 8.1 2.5 2 0 0 2 2 2 0 Nuclear envelope localisation domain SUIM_assoc PF16619.5 CDI82634.1 - 2.2e-05 24.4 0.2 2.2e-05 24.4 0.2 7.9 3 3 1 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 DUF812 PF05667.11 CDI82634.1 - 1.1 8.1 45.8 1.6 7.5 45.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF5427 PF10310.9 CDI82634.1 - 4.3 6.2 48.1 0.5 9.3 17.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5427) RskA PF10099.9 CDI82636.1 - 3e-05 24.4 49.1 0.0019 18.5 15.6 3.6 1 1 2 4 4 4 2 Anti-sigma-K factor rskA Med15 PF09606.10 CDI82636.1 - 0.002 16.9 50.0 0.044 12.5 7.0 2.1 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3675 PF12428.8 CDI82636.1 - 0.013 16.0 2.9 0.013 16.0 2.9 4.1 4 2 2 6 6 4 0 Protein of unknown function (DUF3675) ANAPC_CDC26 PF10471.9 CDI82636.1 - 0.03 15.1 11.8 0.03 15.1 11.8 5.2 5 1 1 6 6 4 0 Anaphase-promoting complex APC subunit CDC26 Gaa1 PF04114.14 CDI82636.1 - 0.078 12.0 5.6 0.92 8.5 0.4 2.9 3 0 0 3 3 3 0 Gaa1-like, GPI transamidase component MAM33 PF02330.16 CDI82636.1 - 0.12 12.3 12.9 0.36 10.7 1.9 3.1 3 0 0 3 3 3 0 Mitochondrial glycoprotein HNOBA PF07701.14 CDI82636.1 - 0.47 9.8 0.0 0.47 9.8 0.0 3.0 2 1 0 2 2 1 0 Heme NO binding associated MFS_Mycoplasma PF07672.13 CDI82636.1 - 0.58 9.4 6.9 0.45 9.8 0.2 2.9 3 0 0 3 3 3 0 Mycoplasma MFS transporter PH_10 PF15411.6 CDI82636.1 - 0.8 10.0 8.8 0.68 10.2 0.3 3.1 3 0 0 3 3 3 0 Pleckstrin homology domain WBP-1 PF11669.8 CDI82636.1 - 1.3 9.7 11.7 4.5 7.9 1.0 3.7 3 0 0 3 3 3 0 WW domain-binding protein 1 SLC12 PF03522.15 CDI82636.1 - 2 7.4 15.9 4.5 6.2 8.6 2.2 2 0 0 2 2 2 0 Solute carrier family 12 Peroxin-13_N PF04088.13 CDI82636.1 - 2 8.7 10.5 19 5.5 0.0 3.6 3 1 1 4 4 4 0 Peroxin 13, N-terminal region CIAPIN1 PF05093.13 CDI82636.1 - 2.8 8.5 17.0 1.1 9.8 3.4 3.5 3 0 0 3 3 3 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Ndc1_Nup PF09531.10 CDI82636.1 - 2.9 6.5 19.1 3.3 6.3 11.7 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 CDI82636.1 - 3.5 5.8 29.7 0.99 7.6 0.4 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Phostensin_N PF13916.6 CDI82636.1 - 4.3 7.7 29.4 0.37 11.2 3.9 3.6 3 0 0 3 3 2 0 PP1-regulatory protein, Phostensin N-terminal Activator_LAG-3 PF11498.8 CDI82636.1 - 4.9 6.0 61.4 0.52 9.2 4.8 3.2 3 0 0 3 3 3 0 Transcriptional activator LAG-3 DUF2367 PF10164.9 CDI82636.1 - 5.2 7.6 13.2 2.5 8.6 0.8 3.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2367) RED_N PF07808.13 CDI82636.1 - 9.8 5.7 21.8 0.36 10.4 1.4 3.2 3 0 0 3 3 3 0 RED-like protein N-terminal region ZnuA PF01297.17 CDI82637.1 - 2.1 7.7 17.7 2.5 7.5 4.0 2.3 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic DUF2722 PF10846.8 CDI82647.1 - 0.0071 15.3 0.9 0.0071 15.3 0.9 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI82648.1 - 0.042 14.1 0.8 0.061 13.6 0.8 1.3 1 1 0 1 1 1 0 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI82651.1 - 0.0045 17.0 8.1 0.011 15.8 8.1 1.6 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 ANAPC_CDC26 PF10471.9 CDI82651.1 - 0.028 15.2 9.5 0.028 15.2 9.5 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 DUF1948 PF09185.10 CDI82651.1 - 0.033 14.1 1.3 0.047 13.5 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1948) PIP5K PF01504.18 CDI82651.1 - 0.058 12.6 0.2 0.072 12.3 0.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Spt20 PF12090.8 CDI82651.1 - 0.079 12.6 9.6 0.11 12.1 9.6 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI82651.1 - 0.32 10.9 11.0 0.4 10.6 11.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 CDI82651.1 - 0.9 8.6 5.5 1.2 8.2 5.5 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Chorion_2 PF03964.15 CDI82651.1 - 2.2 9.2 11.4 8 7.4 5.4 2.3 2 0 0 2 2 2 0 Chorion family 2 Androgen_recep PF02166.16 CDI82651.1 - 3.4 6.4 24.3 0.14 11.0 9.7 2.3 2 0 0 2 2 2 0 Androgen receptor Polyoma_coat2 PF00761.20 CDI82651.1 - 4 7.1 14.6 0.27 10.9 7.6 1.9 2 0 0 2 2 2 0 Polyomavirus coat protein GHMP_kinases_N PF00288.26 CDI82651.1 - 4 7.7 11.4 1.3 9.3 6.2 2.3 2 0 0 2 2 2 0 GHMP kinases N terminal domain TALPID3 PF15324.6 CDI82651.1 - 5 4.7 15.5 2.1 5.9 1.4 2.0 2 0 0 2 2 2 0 Hedgehog signalling target CopD PF05425.13 CDI82652.1 - 0.00046 20.6 0.0 0.00048 20.5 0.0 1.1 1 0 0 1 1 1 1 Copper resistance protein D TMEM52 PF14979.6 CDI82652.1 - 0.0013 18.7 0.4 0.0015 18.5 0.4 1.2 1 0 0 1 1 1 1 Transmembrane 52 DUF3675 PF12428.8 CDI82652.1 - 0.0046 17.5 0.5 0.0058 17.2 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3675) SARAF PF06682.12 CDI82652.1 - 0.0065 16.2 0.1 0.0071 16.0 0.1 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis TMEM51 PF15345.6 CDI82652.1 - 0.0073 16.2 3.7 0.008 16.0 3.7 1.0 1 0 0 1 1 1 1 Transmembrane protein 51 Zn_peptidase PF04228.13 CDI82652.1 - 0.022 14.2 0.2 0.022 14.2 0.2 1.0 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase TMEM154 PF15102.6 CDI82652.1 - 0.029 14.3 0.2 0.032 14.2 0.2 1.1 1 0 0 1 1 1 0 TMEM154 protein family UPF0542 PF15086.6 CDI82652.1 - 0.1 12.6 0.6 0.13 12.2 0.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 GspL_C PF12693.7 CDI82652.1 - 0.11 12.4 9.1 0.13 12.1 9.1 1.1 1 0 0 1 1 1 0 GspL periplasmic domain Plant_vir_prot PF01307.17 CDI82652.1 - 0.12 12.6 0.5 0.14 12.4 0.5 1.3 1 0 0 1 1 1 0 Plant viral movement protein Orf78 PF06024.12 CDI82652.1 - 0.18 12.1 2.0 0.3 11.4 2.0 1.4 1 1 0 1 1 1 0 Orf78 (ac78) EphA2_TM PF14575.6 CDI82652.1 - 0.55 11.2 4.7 0.35 11.8 1.7 1.9 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain YajC PF02699.15 CDI82652.1 - 1.4 8.9 7.0 1.9 8.4 7.0 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit TFIIA PF03153.13 CDI82654.1 - 0.032 14.2 18.4 0.049 13.6 18.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI82654.1 - 0.48 10.5 12.2 0.2 11.8 7.4 2.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI82654.1 - 1.7 8.2 12.8 0.069 12.8 6.1 1.8 2 0 0 2 2 2 0 Spt20 family AP2 PF00847.20 CDI82661.1 - 0.00025 21.2 1.5 0.00076 19.7 1.5 1.9 1 0 0 1 1 1 1 AP2 domain Peptidase_S8 PF00082.22 CDI82662.1 - 1.9e-23 83.2 1.2 3.8e-18 65.8 0.1 2.2 1 1 1 2 2 2 2 Subtilase family PrmA PF06325.13 CDI82663.1 - 0.022 14.2 0.0 0.18 11.2 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) PRMT5_C PF17286.2 CDI82663.1 - 0.035 14.0 0.0 0.09 12.6 0.0 1.6 1 1 0 1 1 1 0 PRMT5 oligomerisation domain Methyltransf_3 PF01596.17 CDI82663.1 - 0.1 11.8 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase CMAS PF02353.20 CDI82663.1 - 0.14 11.5 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Serpin PF00079.20 CDI82664.1 - 9.7e-79 265.3 0.2 1.2e-78 265.0 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SR-25 PF10500.9 CDI82665.1 - 0.00018 21.2 42.5 0.00039 20.1 10.9 2.7 2 1 0 2 2 2 2 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI82665.1 - 0.00092 19.2 0.2 0.00092 19.2 0.2 5.8 1 1 2 3 3 1 1 Unstructured region C-term to UIM in Ataxin3 ASD2 PF08687.11 CDI82665.1 - 0.043 13.4 27.7 0.099 12.2 4.0 2.3 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 EPL1 PF10513.9 CDI82665.1 - 0.079 13.3 29.3 0.63 10.4 5.6 2.6 2 0 0 2 2 2 0 Enhancer of polycomb-like TCP PF03634.13 CDI82665.1 - 0.17 12.4 37.7 0.92 10.1 19.4 2.6 2 0 0 2 2 2 0 TCP family transcription factor PA26 PF04636.13 CDI82665.1 - 0.71 8.7 20.8 0.88 8.4 2.4 2.2 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Band_3_cyto PF07565.13 CDI82665.1 - 0.71 9.6 22.3 1 9.1 1.6 2.4 2 0 0 2 2 2 0 Band 3 cytoplasmic domain SLC12 PF03522.15 CDI82665.1 - 0.74 8.8 25.6 1.1 8.2 1.5 2.2 2 0 0 2 2 2 0 Solute carrier family 12 FAM60A PF15396.6 CDI82665.1 - 0.83 9.6 20.9 0.78 9.7 1.8 2.6 2 0 0 2 2 2 0 Protein Family FAM60A eIF-3_zeta PF05091.12 CDI82665.1 - 1.1 8.2 30.5 9.9 5.0 3.7 3.3 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SpoIIP PF07454.11 CDI82665.1 - 1.6 8.1 22.9 1.3 8.4 3.3 2.6 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Adaptin_binding PF10199.9 CDI82665.1 - 2.5 8.7 32.6 0.38 11.4 8.7 3.4 1 1 1 2 2 2 0 Alpha and gamma adaptin binding protein p34 Mcm10 PF09332.11 CDI82665.1 - 2.8 7.3 27.2 2.3 7.6 4.0 2.5 2 0 0 2 2 2 0 Mcm10 replication factor Endostatin PF06482.11 CDI82665.1 - 3 7.2 25.2 3.8 6.9 2.3 2.2 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin CDK5_activator PF03261.15 CDI82665.1 - 4.6 6.7 20.1 5.3 6.5 0.9 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein Peptidase_S64 PF08192.11 CDI82665.1 - 5.1 5.4 25.4 0.75 8.2 3.5 2.2 2 0 0 2 2 2 0 Peptidase family S64 NPR3 PF03666.13 CDI82665.1 - 6.8 5.4 25.9 1.2 7.8 5.1 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 CobT PF06213.12 CDI82665.1 - 9.7 5.5 40.5 0.13 11.7 8.5 2.6 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF3112 PF11309.8 CDI82668.1 - 0.67 9.4 10.1 0.82 9.1 10.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Bac_export_2 PF01312.19 CDI82668.1 - 3.9 6.6 12.8 4.4 6.4 12.8 1.0 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Phage_holin_3_6 PF07332.11 CDI82668.1 - 6 7.0 17.8 6.1 6.9 17.8 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III RskA PF10099.9 CDI82670.1 - 0.009 16.3 6.8 0.012 15.9 6.8 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Chorismate_synt PF01264.21 CDI82670.1 - 0.052 12.3 2.4 0.057 12.1 2.4 1.0 1 0 0 1 1 1 0 Chorismate synthase THOC2_N PF16134.5 CDI82670.1 - 1.8 7.1 13.5 1.9 7.0 13.5 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus IF-2B PF01008.17 CDI82670.1 - 5.6 6.1 8.7 5.8 6.0 8.7 1.0 1 0 0 1 1 1 0 Initiation factor 2 subunit family Plasmodium_Vir PF05795.11 CDI82670.1 - 5.7 6.2 11.6 6.1 6.2 11.6 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SLC12 PF03522.15 CDI82673.1 - 0.22 10.5 33.7 0.26 10.3 33.7 1.3 1 0 0 1 1 1 0 Solute carrier family 12 AAA_11 PF13086.6 CDI82673.1 - 0.31 10.8 30.3 0.38 10.5 30.3 1.2 1 0 0 1 1 1 0 AAA domain ALMT PF11744.8 CDI82673.1 - 0.42 9.4 22.8 0.49 9.2 22.8 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM222A PF15258.6 CDI82673.1 - 0.83 8.7 46.2 0.9 8.6 46.2 1.2 1 0 0 1 1 1 0 Protein family of FAM222A Hamartin PF04388.12 CDI82673.1 - 1.2 7.7 37.5 1.6 7.3 37.5 1.2 1 0 0 1 1 1 0 Hamartin protein PA26 PF04636.13 CDI82673.1 - 1.3 7.9 24.0 1.4 7.8 24.0 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF2151 PF10221.9 CDI82673.1 - 2.7 6.5 19.7 3.2 6.2 19.7 1.3 1 0 0 1 1 1 0 Cell cycle and development regulator MCM_bind PF09739.9 CDI82673.1 - 5.5 5.3 29.6 6.9 5.0 29.6 1.4 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Membralin PF09746.9 CDI82673.1 - 6.9 5.6 21.9 8.8 5.2 21.9 1.2 1 0 0 1 1 1 0 Tumour-associated protein PAT1 PF09770.9 CDI82673.1 - 9.8 4.3 61.2 12 4.0 61.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PRC2_HTH_1 PF18118.1 CDI82675.1 - 0.032 15.0 10.5 0.032 15.0 10.5 2.0 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain SARAF PF06682.12 CDI82675.1 - 0.043 13.5 16.3 0.051 13.2 16.3 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Presenilin PF01080.17 CDI82675.1 - 0.37 9.5 30.1 0.43 9.3 30.1 1.0 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 CDI82675.1 - 0.73 8.2 12.2 0.91 7.8 12.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Rgp1 PF08737.10 CDI82675.1 - 0.92 8.6 27.3 0.97 8.5 27.3 1.0 1 0 0 1 1 1 0 Rgp1 cwf18 PF08315.12 CDI82675.1 - 1.9 9.2 25.2 2 9.1 25.2 1.0 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor Serinc PF03348.15 CDI82675.1 - 2 7.2 16.0 2.3 7.1 16.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF572 PF04502.13 CDI82675.1 - 2.4 7.7 24.8 3.2 7.3 24.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4050 PF13259.6 CDI82675.1 - 2.7 8.3 22.0 3.6 7.9 22.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) DUF3357 PF11837.8 CDI82675.1 - 4 8.0 5.5 6.7 7.2 5.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) Senescence_reg PF04520.13 CDI82675.1 - 4.7 8.0 19.4 5.4 7.8 19.4 1.1 1 0 0 1 1 1 0 Senescence regulator CCSAP PF15748.5 CDI82675.1 - 5.2 7.2 29.7 7.1 6.7 29.7 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF5427 PF10310.9 CDI82675.1 - 8.1 5.3 26.8 11 4.8 26.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF2722 PF10846.8 CDI82677.1 - 0.00043 19.4 6.5 0.00043 19.4 6.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF702 PF05142.12 CDI82677.1 - 0.017 15.6 2.1 0.017 15.6 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) tRNA_lig_CPD PF08302.11 CDI82677.1 - 0.018 14.5 1.1 0.024 14.1 1.1 1.1 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain NAD_binding_6 PF08030.12 CDI82677.1 - 0.023 14.8 0.1 0.029 14.5 0.1 1.1 1 0 0 1 1 1 0 Ferric reductase NAD binding domain DUF5336 PF17270.2 CDI82677.1 - 0.032 13.8 2.5 0.039 13.6 2.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5336) Trp_oprn_chp PF09534.10 CDI82677.1 - 0.035 13.9 0.2 0.039 13.7 0.2 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Prp18 PF02840.15 CDI82677.1 - 0.04 14.0 5.9 0.05 13.6 5.9 1.1 1 0 0 1 1 1 0 Prp18 domain DUF3464 PF11947.8 CDI82677.1 - 0.063 13.0 0.6 0.068 12.9 0.6 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DivIC PF04977.15 CDI82677.1 - 0.18 11.6 12.6 0.26 11.1 12.6 1.2 1 0 0 1 1 1 0 Septum formation initiator DUF4199 PF13858.6 CDI82677.1 - 0.18 12.2 1.3 0.23 11.9 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) TFIIA PF03153.13 CDI82677.1 - 0.29 11.1 12.5 0.33 10.9 12.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 CDI82677.1 - 0.42 11.6 5.2 0.66 11.0 5.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) MscS_TM PF12794.7 CDI82677.1 - 0.45 9.3 3.9 0.52 9.1 3.9 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 AMP-binding PF00501.28 CDI82678.1 - 0.22 10.1 6.7 0.26 9.9 6.7 1.1 1 0 0 1 1 1 0 AMP-binding enzyme Lin-8 PF03353.15 CDI82678.1 - 1.6 8.3 33.3 1.7 8.1 33.3 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist eIF3_subunit PF08597.10 CDI82678.1 - 2.7 7.8 25.3 3.2 7.6 25.3 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DDRGK PF09756.9 CDI82678.1 - 3.9 7.0 32.8 5 6.7 32.8 1.2 1 0 0 1 1 1 0 DDRGK domain Rtf2 PF04641.12 CDI82678.1 - 8.4 5.7 26.0 9.1 5.6 26.0 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger AF-4 PF05110.13 CDI82678.1 - 8.9 4.2 36.6 14 3.6 36.6 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4551 PF15087.6 CDI82679.1 - 0.04 12.8 21.0 0.049 12.5 21.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SR-25 PF10500.9 CDI82679.1 - 0.16 11.5 41.2 0.08 12.5 21.4 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein SOBP PF15279.6 CDI82679.1 - 0.88 10.1 26.2 1.3 9.6 26.2 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Hamartin PF04388.12 CDI82679.1 - 4.6 5.8 34.5 6.1 5.4 34.5 1.1 1 0 0 1 1 1 0 Hamartin protein PAT1 PF09770.9 CDI82679.1 - 6.6 4.9 54.0 7.8 4.6 54.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RskA PF10099.9 CDI82680.1 - 5.5e-10 39.8 8.9 1.4e-07 32.0 0.1 9.2 2 2 4 8 8 8 3 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI82680.1 - 4.9e-05 23.1 7.1 0.00027 20.6 5.7 10.2 5 2 4 10 10 10 4 Spt20 family Med15 PF09606.10 CDI82680.1 - 0.0023 16.7 8.5 0.0023 16.7 8.5 7.6 3 2 2 5 5 5 1 ARC105 or Med15 subunit of Mediator complex non-fungal SR-25 PF10500.9 CDI82680.1 - 0.0052 16.4 9.1 0.0052 16.4 9.1 10.7 5 3 5 10 10 10 2 Nuclear RNA-splicing-associated protein DUF1645 PF07816.11 CDI82680.1 - 0.0054 17.3 1.6 0.0054 17.3 1.6 10.5 4 2 5 9 9 9 1 Protein of unknown function (DUF1645) VIT1 PF01988.19 CDI82681.1 - 1.6 8.5 17.9 2.3 8.0 17.9 1.3 1 0 0 1 1 1 0 VIT family FRQ PF09421.10 CDI82681.1 - 3 5.8 15.7 3.2 5.7 15.7 1.0 1 0 0 1 1 1 0 Frequency clock protein Ten_N PF06484.12 CDI82681.1 - 9 6.1 25.7 9.4 6.0 25.7 1.0 1 0 0 1 1 1 0 Teneurin Intracellular Region SUIM_assoc PF16619.5 CDI82682.1 - 0.0023 17.9 5.8 0.005 16.9 5.8 1.5 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 DUF3439 PF11921.8 CDI82682.1 - 0.0055 16.7 1.6 0.0073 16.3 1.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) Sporozoite_P67 PF05642.11 CDI82682.1 - 0.097 10.7 7.7 0.12 10.4 7.7 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Spt20 PF12090.8 CDI82682.1 - 0.17 11.4 9.2 0.21 11.2 9.2 1.1 1 0 0 1 1 1 0 Spt20 family Rotamase_2 PF13145.6 CDI82682.1 - 0.22 12.3 11.7 0.28 12.0 11.7 1.3 1 0 0 1 1 1 0 PPIC-type PPIASE domain TFIIA PF03153.13 CDI82682.1 - 0.24 11.3 8.7 0.27 11.2 8.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SAP130_C PF16014.5 CDI82682.1 - 0.45 9.5 14.7 0.47 9.5 14.7 1.0 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus MGC-24 PF05283.11 CDI82682.1 - 1.2 9.6 6.8 1.5 9.3 6.8 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin CDC27 PF09507.10 CDI82682.1 - 1.3 8.3 7.1 1.6 8.1 7.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Ndc1_Nup PF09531.10 CDI82682.1 - 2.8 6.5 6.5 2.8 6.5 6.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Tic110 PF16940.5 CDI82682.1 - 2.9 6.3 14.5 3.3 6.1 14.5 1.0 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF1387 PF07139.11 CDI82686.1 - 7.2 6.2 36.6 1 9.1 12.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) CDC45 PF02724.14 CDI82686.1 - 8.4 4.5 31.6 0.36 9.1 17.0 2.2 2 0 0 2 2 2 0 CDC45-like protein DUF4207 PF13904.6 CDI82688.1 - 0.0022 17.7 9.1 0.0022 17.7 9.1 4.3 2 1 1 3 3 3 1 Domain of unknown function (DUF4207) Conotoxin PF02950.17 CDI82689.1 - 0.0053 17.8 6.4 0.0053 17.8 6.4 4.9 4 1 0 4 4 4 1 Conotoxin Utp14 PF04615.13 CDI82689.1 - 0.0067 15.1 31.2 0.0089 14.7 31.2 1.2 1 0 0 1 1 1 1 Utp14 protein DUF1345 PF07077.11 CDI82689.1 - 1.2 8.8 3.0 2.2 8.0 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) DUF819 PF05684.12 CDI82689.1 - 7.4 5.5 5.6 1.2 8.1 0.1 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF819) PRP38_assoc PF12871.7 CDI82690.1 - 0.75 10.4 82.9 1.8e+04 -12.5 82.9 2.9 1 1 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF2722 PF10846.8 CDI82692.1 - 0.012 14.6 2.8 0.013 14.4 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI82692.1 - 0.015 14.9 7.5 0.015 14.9 7.5 1.1 1 0 0 1 1 1 0 Spt20 family ANAPC8 PF04049.13 CDI82692.1 - 0.071 13.2 2.1 0.082 13.0 2.1 1.3 1 1 0 1 1 1 0 Anaphase promoting complex subunit 8 / Cdc23 TFIIA PF03153.13 CDI82692.1 - 0.19 11.7 9.5 0.22 11.5 9.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MLANA PF14991.6 CDI82692.1 - 0.31 11.3 5.1 0.075 13.3 2.1 1.5 1 1 0 1 1 1 0 Protein melan-A SUIM_assoc PF16619.5 CDI82692.1 - 0.65 10.1 14.7 1.1 9.4 14.7 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PsaL PF02605.15 CDI82692.1 - 5.4 6.7 7.1 0.44 10.2 1.2 1.9 1 1 1 2 2 2 0 Photosystem I reaction centre subunit XI Orf78 PF06024.12 CDI82694.1 - 0.00025 21.3 5.6 0.00029 21.1 5.6 1.1 1 0 0 1 1 1 1 Orf78 (ac78) Consortin_C PF15281.6 CDI82694.1 - 0.0017 18.3 1.9 0.0019 18.2 1.9 1.1 1 0 0 1 1 1 1 Consortin C-terminus DUF4366 PF14283.6 CDI82694.1 - 0.002 18.2 1.8 0.0022 18.1 1.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) CobT PF06213.12 CDI82694.1 - 0.0031 17.0 13.6 0.0031 17.0 13.6 1.1 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT PBP1_TM PF14812.6 CDI82694.1 - 0.0051 17.1 1.1 0.0068 16.7 1.1 1.2 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal CrgA PF06781.12 CDI82694.1 - 0.0074 16.3 0.4 0.009 16.0 0.4 1.2 1 0 0 1 1 1 1 Cell division protein CrgA Peroxin-13_N PF04088.13 CDI82694.1 - 0.014 15.7 6.4 0.016 15.5 6.4 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Kei1 PF08552.11 CDI82694.1 - 0.017 15.0 5.4 0.02 14.8 5.4 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Eapp_C PF10238.9 CDI82694.1 - 0.019 15.0 8.7 0.017 15.2 8.7 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein DcuC PF03606.15 CDI82694.1 - 0.021 13.3 2.6 0.022 13.2 2.6 1.0 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier Peptidase_M56 PF05569.11 CDI82694.1 - 0.022 13.9 1.5 0.022 13.9 1.5 1.0 1 0 0 1 1 1 0 BlaR1 peptidase M56 Presenilin PF01080.17 CDI82694.1 - 0.022 13.5 10.2 0.02 13.6 10.2 1.1 1 0 0 1 1 1 0 Presenilin DUF3464 PF11947.8 CDI82694.1 - 0.025 14.4 9.2 0.026 14.3 9.2 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 GET2 PF08690.10 CDI82694.1 - 0.029 14.1 14.1 0.03 14.0 14.1 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 Connexin PF00029.19 CDI82694.1 - 0.033 13.9 8.2 0.038 13.8 8.2 1.1 1 0 0 1 1 1 0 Connexin SLD3 PF08639.10 CDI82694.1 - 0.035 12.9 11.1 0.035 12.9 11.1 1.0 1 0 0 1 1 1 0 DNA replication regulator SLD3 SpoIIP PF07454.11 CDI82694.1 - 0.04 13.4 11.5 0.036 13.5 11.5 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CPSF100_C PF13299.6 CDI82694.1 - 0.044 14.0 7.8 0.042 14.0 7.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal EIIBC-GUT_N PF03612.14 CDI82694.1 - 0.051 13.3 10.1 0.054 13.2 10.1 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus HCO3_cotransp PF00955.21 CDI82694.1 - 0.065 12.0 3.6 0.07 12.0 3.6 1.0 1 0 0 1 1 1 0 HCO3- transporter family DcuA_DcuB PF03605.14 CDI82694.1 - 0.07 12.0 3.3 0.065 12.1 3.3 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Glt_symporter PF03616.14 CDI82694.1 - 0.073 11.7 6.6 0.071 11.8 6.6 1.0 1 0 0 1 1 1 0 Sodium/glutamate symporter Pex14_N PF04695.13 CDI82694.1 - 0.079 13.6 21.4 0.078 13.6 21.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region UPF0669 PF17065.5 CDI82694.1 - 0.08 12.7 3.1 0.12 12.2 3.1 1.2 1 0 0 1 1 1 0 Putative cytokine, C6ORF120 Gti1_Pac2 PF09729.9 CDI82694.1 - 0.09 12.9 6.0 0.079 13.1 6.0 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family PIP5K PF01504.18 CDI82694.1 - 0.12 11.5 7.9 0.13 11.5 7.9 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF4770 PF15994.5 CDI82694.1 - 0.13 12.4 12.5 0.13 12.5 12.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF2207 PF09972.9 CDI82694.1 - 0.14 10.9 0.8 0.15 10.8 0.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2370 PF10176.9 CDI82694.1 - 0.15 11.6 3.2 0.16 11.6 3.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Rxt3 PF08642.10 CDI82694.1 - 0.16 12.8 7.0 0.17 12.7 7.0 1.1 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 DUF3675 PF12428.8 CDI82694.1 - 0.16 12.5 2.5 0.2 12.2 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) DDHD PF02862.17 CDI82694.1 - 0.19 11.9 9.7 0.16 12.1 9.7 1.1 1 0 0 1 1 1 0 DDHD domain BRF1 PF07741.13 CDI82694.1 - 0.19 12.1 9.6 0.19 12.1 9.6 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Peptidase_S49_N PF08496.10 CDI82694.1 - 0.21 11.7 9.0 0.2 11.7 9.0 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Tmem26 PF09772.9 CDI82694.1 - 0.22 10.8 7.4 0.23 10.8 7.4 1.0 1 0 0 1 1 1 0 Transmembrane protein 26 DUF872 PF05915.12 CDI82694.1 - 0.24 11.6 0.9 0.26 11.5 0.9 1.0 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) Neur_chan_memb PF02932.16 CDI82694.1 - 0.27 11.3 8.5 0.27 11.3 8.5 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Renin_r PF07850.14 CDI82694.1 - 0.28 11.8 4.0 0.35 11.5 4.0 1.2 1 0 0 1 1 1 0 Renin receptor-like protein LAP1C PF05609.12 CDI82694.1 - 0.29 10.2 11.0 0.29 10.2 11.0 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PPL5 PF18168.1 CDI82694.1 - 0.33 10.2 5.2 0.33 10.2 5.2 1.1 1 0 0 1 1 1 0 Prim-pol family 5 RICTOR_N PF14664.6 CDI82694.1 - 0.36 9.8 8.9 0.34 9.9 8.9 1.0 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term TMEM144 PF07857.12 CDI82694.1 - 0.37 9.7 0.8 0.4 9.6 0.8 1.0 1 0 0 1 1 1 0 Transmembrane family, TMEM144 of transporters GWT1 PF06423.12 CDI82694.1 - 0.37 10.9 1.6 0.48 10.5 1.6 1.3 1 0 0 1 1 1 0 GWT1 EPL1 PF10513.9 CDI82694.1 - 0.38 11.1 12.6 0.35 11.3 12.6 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like RR_TM4-6 PF06459.12 CDI82694.1 - 0.38 10.5 11.5 0.41 10.4 11.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Folate_carrier PF01770.18 CDI82694.1 - 0.39 9.4 7.8 0.39 9.4 7.8 1.0 1 0 0 1 1 1 0 Reduced folate carrier OATP PF03137.20 CDI82694.1 - 0.43 8.8 7.3 0.44 8.8 7.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family PAT1 PF09770.9 CDI82694.1 - 0.46 8.7 21.2 0.42 8.8 21.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4175 PF13779.6 CDI82694.1 - 0.48 8.3 32.7 0.44 8.4 32.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4064 PF13273.6 CDI82694.1 - 0.48 10.7 2.5 0.68 10.2 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) Band_3_cyto PF07565.13 CDI82694.1 - 0.52 10.1 10.8 0.56 10.0 10.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TMEM164 PF14808.6 CDI82694.1 - 0.53 9.6 3.4 0.63 9.3 3.4 1.2 1 0 0 1 1 1 0 TMEM164 family CCDC53 PF10152.9 CDI82694.1 - 0.55 10.6 12.8 0.62 10.5 12.8 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex tRNA_synt_1c_R2 PF04557.15 CDI82694.1 - 0.63 11.0 9.4 0.81 10.6 9.4 1.2 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 SMYLE_N PF18615.1 CDI82694.1 - 0.63 9.5 9.4 0.62 9.6 9.4 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain MDM10 PF12519.8 CDI82694.1 - 0.66 8.8 8.5 0.56 9.0 8.5 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 RED_N PF07808.13 CDI82694.1 - 0.75 9.3 14.8 0.76 9.3 14.8 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region EOS1 PF12326.8 CDI82694.1 - 0.78 9.6 5.8 0.84 9.5 5.8 1.1 1 0 0 1 1 1 0 N-glycosylation protein ALMT PF11744.8 CDI82694.1 - 0.79 8.5 7.1 0.79 8.5 7.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter 7tm_1 PF00001.21 CDI82694.1 - 0.83 8.9 2.2 0.94 8.7 2.2 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) CSG2 PF16965.5 CDI82694.1 - 0.91 8.4 7.2 0.99 8.3 7.2 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 CDI82694.1 - 0.95 8.4 8.8 0.98 8.4 8.8 1.0 1 0 0 1 1 1 0 CLN3 protein TFIIA PF03153.13 CDI82694.1 - 0.98 9.3 38.0 0.92 9.4 38.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Velvet PF11754.8 CDI82694.1 - 1.1 9.1 12.1 1.1 9.1 12.1 1.1 1 0 0 1 1 1 0 Velvet factor Zip PF02535.22 CDI82694.1 - 1.2 8.3 5.9 1.2 8.3 5.9 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Serinc PF03348.15 CDI82694.1 - 1.3 7.9 6.5 1.3 7.9 6.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) ORC_WH_C PF18137.1 CDI82694.1 - 1.3 9.0 12.6 1.6 8.8 12.6 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal YABBY PF04690.13 CDI82694.1 - 1.4 9.5 8.0 1.3 9.5 8.0 1.1 1 0 0 1 1 1 0 YABBY protein DUF4400 PF14348.6 CDI82694.1 - 1.5 8.2 5.2 1.7 8.1 5.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) MDM31_MDM32 PF08118.11 CDI82694.1 - 1.6 7.3 10.7 1.7 7.2 10.7 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins FAM60A PF15396.6 CDI82694.1 - 1.8 8.5 9.4 1.9 8.4 9.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A MMR1 PF08505.10 CDI82694.1 - 1.8 8.8 15.8 1.6 9.0 15.8 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF775 PF05603.12 CDI82694.1 - 1.8 8.0 15.9 2 7.9 15.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Suf PF05843.14 CDI82694.1 - 1.9 8.4 21.3 2 8.3 21.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CD20 PF04103.15 CDI82694.1 - 1.9 8.5 3.3 2.2 8.4 3.3 1.1 1 0 0 1 1 1 0 CD20-like family ABC2_membrane_3 PF12698.7 CDI82694.1 - 2.1 7.4 5.7 2.1 7.4 5.7 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein PUCC PF03209.15 CDI82694.1 - 2.2 7.2 5.0 2.4 7.0 5.0 1.0 1 0 0 1 1 1 0 PUCC protein Scs3p PF10261.9 CDI82694.1 - 2.5 7.6 5.3 2.8 7.4 5.3 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM GNAT_acetyltr_2 PF13718.6 CDI82694.1 - 2.5 7.4 10.1 2.7 7.3 10.1 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 V_ATPase_I PF01496.19 CDI82694.1 - 2.7 5.8 14.3 2.8 5.7 14.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ndc1_Nup PF09531.10 CDI82694.1 - 3.1 6.4 10.3 2.9 6.5 10.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SID-1_RNA_chan PF13965.6 CDI82694.1 - 3.2 6.1 5.9 3.3 6.0 5.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 MecA PF05389.12 CDI82694.1 - 3.2 7.3 13.7 3.5 7.2 13.7 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF3405 PF11885.8 CDI82694.1 - 4.6 5.7 12.1 5 5.6 12.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) Pex26 PF07163.12 CDI82694.1 - 5.2 6.3 18.3 5.6 6.2 18.3 1.1 1 0 0 1 1 1 0 Pex26 protein Asparaginase_2 PF01112.18 CDI82694.1 - 5.4 5.9 7.1 4.8 6.1 7.1 1.0 1 0 0 1 1 1 0 Asparaginase AIF_C PF14721.6 CDI82694.1 - 5.5 7.3 12.4 6.7 7.1 12.4 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Ctr PF04145.15 CDI82694.1 - 5.6 7.6 9.3 6.3 7.4 9.3 1.1 1 0 0 1 1 1 0 Ctr copper transporter family TMEM51 PF15345.6 CDI82694.1 - 5.8 6.7 18.0 6.8 6.5 18.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 FHIPEP PF00771.20 CDI82694.1 - 6 5.2 12.9 5.5 5.3 12.9 1.0 1 0 0 1 1 1 0 FHIPEP family ABC2_membrane_2 PF12679.7 CDI82694.1 - 6.4 6.0 10.0 7 5.8 10.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Nucleoside_tran PF01733.18 CDI82694.1 - 6.6 6.0 7.0 7.1 5.9 7.0 1.1 1 0 0 1 1 1 0 Nucleoside transporter DUF1682 PF07946.14 CDI82694.1 - 6.6 5.8 11.8 6.4 5.9 11.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Maf1 PF09174.10 CDI82694.1 - 7 6.8 9.6 7.6 6.7 9.6 1.1 1 0 0 1 1 1 0 Maf1 regulator DUF2126 PF09899.9 CDI82694.1 - 7 4.6 10.4 7.2 4.5 10.4 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Arv1 PF04161.13 CDI82694.1 - 7.1 6.7 6.5 8.1 6.5 6.5 1.1 1 0 0 1 1 1 0 Arv1-like family PigN PF04987.14 CDI82694.1 - 7.3 5.3 11.7 8.1 5.2 11.7 1.0 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Het-C PF07217.11 CDI82694.1 - 7.6 4.9 9.6 7.4 5.0 9.6 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF1644 PF07800.12 CDI82694.1 - 9.4 6.3 10.8 10 6.1 10.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1644) DUF4457 PF14652.6 CDI82694.1 - 9.7 5.3 10.8 9.7 5.3 10.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) VKG_Carbox PF05090.14 CDI82694.1 - 9.8 4.9 9.4 10 4.8 9.4 1.0 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase SARAF PF06682.12 CDI82697.1 - 0.0023 17.7 10.3 0.003 17.3 10.3 1.3 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Gaa1 PF04114.14 CDI82697.1 - 0.0049 15.9 3.7 0.0057 15.7 3.7 1.0 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component DUF2298 PF10060.9 CDI82697.1 - 0.14 10.8 3.5 0.18 10.5 3.5 1.1 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) DUF979 PF06166.12 CDI82697.1 - 0.16 11.1 6.9 0.042 13.0 3.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF979) Presenilin PF01080.17 CDI82697.1 - 0.23 10.2 15.6 0.28 9.9 15.6 1.3 1 0 0 1 1 1 0 Presenilin Dsh_C PF12316.8 CDI82697.1 - 0.37 11.2 10.5 0.48 10.8 10.5 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Myc_N PF01056.18 CDI82697.1 - 0.44 10.4 13.4 0.54 10.1 13.4 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Mit_KHE1 PF10173.9 CDI82697.1 - 0.47 10.5 6.4 0.6 10.2 6.4 1.2 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Lin-8 PF03353.15 CDI82697.1 - 0.95 9.0 17.7 1.1 8.7 17.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2459 PF09601.10 CDI82697.1 - 2.1 8.2 9.5 3.6 7.4 9.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2459) Otopetrin PF03189.13 CDI82697.1 - 2.3 6.9 7.4 3 6.6 7.4 1.2 1 0 0 1 1 1 0 Otopetrin CDK5_activator PF03261.15 CDI82697.1 - 2.3 7.7 12.7 2.5 7.5 12.7 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Ribonuc_P_40 PF08584.11 CDI82697.1 - 2.8 7.1 8.6 3.2 6.9 8.6 1.1 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit DUF572 PF04502.13 CDI82697.1 - 3 7.4 13.6 4.1 6.9 13.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) PA26 PF04636.13 CDI82697.1 - 3.3 6.5 11.0 4.1 6.2 11.0 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) O-antigen_lig PF13425.6 CDI82697.1 - 4.1 6.1 4.9 5.2 5.7 4.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF2339 PF10101.9 CDI82697.1 - 4.3 5.8 11.5 5.4 5.5 11.5 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2339) Exonuc_VII_L PF02601.15 CDI82697.1 - 5.7 6.4 20.9 6.8 6.2 20.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PepSY_TM_like_2 PF16357.5 CDI82697.1 - 7 6.6 9.8 9.8 6.1 9.8 1.3 1 0 0 1 1 1 0 Putative PepSY_TM-like PAT1 PF09770.9 CDI82697.1 - 7 4.8 28.4 7.3 4.7 28.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Membralin PF09746.9 CDI82697.1 - 7.1 5.6 7.5 8.7 5.3 7.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein CCSAP PF15748.5 CDI82697.1 - 7.5 6.6 18.1 11 6.1 18.1 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF1304 PF06993.12 CDI82697.1 - 9.3 6.3 16.3 0.42 10.6 9.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1304) DUF2722 PF10846.8 CDI82702.1 - 0.00087 18.4 14.2 0.00087 18.4 14.2 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF2722) eIF-3_zeta PF05091.12 CDI82702.1 - 0.068 12.1 10.9 0.14 11.2 10.9 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EIF4E-T PF10477.9 CDI82702.1 - 7.1 5.3 19.8 10 4.8 19.8 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DnaJ PF00226.31 CDI82706.1 - 0.01 15.9 0.2 0.033 14.3 0.0 1.9 2 0 0 2 2 2 0 DnaJ domain Trp_oprn_chp PF09534.10 CDI82706.1 - 0.2 11.4 0.1 0.2 11.4 0.1 4.2 3 1 2 5 5 5 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Cellulose_synt PF03552.14 CDI82706.1 - 3.5 6.0 6.8 0.16 10.5 0.2 1.9 2 0 0 2 2 2 0 Cellulose synthase SARAF PF06682.12 CDI82708.1 - 0.00055 19.7 8.1 0.00065 19.4 8.1 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis V_ATPase_I PF01496.19 CDI82708.1 - 0.0014 16.7 19.2 0.0021 16.1 19.2 1.3 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family SIT PF15330.6 CDI82708.1 - 0.0025 18.2 18.3 0.003 18.0 18.3 1.1 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT Zip PF02535.22 CDI82708.1 - 0.0026 17.0 14.2 0.0033 16.7 14.2 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter TssO PF17561.2 CDI82708.1 - 0.0043 17.2 8.2 0.0043 17.2 8.2 1.9 1 1 1 2 2 1 1 Type VI secretion system, TssO CLN3 PF02487.17 CDI82708.1 - 0.0063 15.6 12.9 0.0073 15.4 12.9 1.1 1 0 0 1 1 1 1 CLN3 protein TMEM51 PF15345.6 CDI82708.1 - 0.014 15.3 8.3 0.014 15.3 8.3 2.0 1 1 1 2 2 2 0 Transmembrane protein 51 DUF4834 PF16118.5 CDI82708.1 - 0.02 15.9 26.5 7.9 7.5 26.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) SID-1_RNA_chan PF13965.6 CDI82708.1 - 0.026 12.9 8.4 0.036 12.5 8.4 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 LptF_LptG PF03739.14 CDI82708.1 - 0.029 13.2 2.7 0.039 12.8 2.6 1.3 1 1 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG K_trans PF02705.16 CDI82708.1 - 0.046 12.2 8.7 0.051 12.1 8.7 1.0 1 0 0 1 1 1 0 K+ potassium transporter NicO PF03824.16 CDI82708.1 - 0.051 12.9 13.0 0.062 12.6 13.0 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein O-antigen_lig PF13425.6 CDI82708.1 - 0.058 12.2 5.9 0.064 12.0 5.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein m04gp34like PF12216.8 CDI82708.1 - 0.058 13.0 2.0 0.057 13.0 1.6 1.2 1 1 0 1 1 1 0 Immune evasion protein Ion_trans PF00520.31 CDI82708.1 - 0.068 12.4 0.0 0.081 12.1 0.0 1.1 1 0 0 1 1 1 0 Ion transport protein Chordopox_G3 PF06129.12 CDI82708.1 - 0.073 13.8 2.2 0.095 13.4 1.9 1.3 1 1 0 1 1 1 0 Chordopoxvirus G3 protein Serinc PF03348.15 CDI82708.1 - 0.12 11.2 5.9 0.16 10.9 5.9 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4131 PF13567.6 CDI82708.1 - 0.14 11.8 7.2 0.21 11.2 7.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) SLC12 PF03522.15 CDI82708.1 - 0.18 10.8 18.8 0.19 10.7 18.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 HemX PF04375.14 CDI82708.1 - 0.2 10.9 38.2 0.23 10.7 38.2 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4381 PF14316.6 CDI82708.1 - 0.32 11.2 14.6 0.44 10.8 14.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Ctr PF04145.15 CDI82708.1 - 0.55 10.8 16.3 2.9 8.5 16.3 1.8 1 1 0 1 1 1 0 Ctr copper transporter family CSG2 PF16965.5 CDI82708.1 - 0.67 8.8 8.8 0.88 8.4 8.8 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator MAPEG PF01124.18 CDI82708.1 - 0.83 9.6 9.0 4.1 7.3 9.0 1.9 1 1 0 1 1 1 0 MAPEG family Otopetrin PF03189.13 CDI82708.1 - 0.89 8.3 14.3 1.2 7.9 14.3 1.3 1 0 0 1 1 1 0 Otopetrin DUF3357 PF11837.8 CDI82708.1 - 1.7 9.1 8.8 0.08 13.4 1.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) TRAP_alpha PF03896.16 CDI82708.1 - 1.9 7.7 9.8 3.2 6.9 9.8 1.5 1 1 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit HemY_N PF07219.13 CDI82708.1 - 2.6 8.3 11.1 0.23 11.7 4.8 2.2 1 1 1 2 2 2 0 HemY protein N-terminus Cytochrom_C_asm PF01578.20 CDI82708.1 - 2.6 7.8 6.6 5.1 6.8 6.6 1.6 1 1 0 1 1 1 0 Cytochrome C assembly protein DUF1345 PF07077.11 CDI82708.1 - 2.6 7.7 5.5 5.7 6.6 5.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1345) DUF2828 PF11443.8 CDI82708.1 - 4.2 5.3 21.2 4.9 5.1 21.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Jiraiya PF15038.6 CDI82708.1 - 4.6 6.7 11.8 0.38 10.2 6.9 1.7 1 1 1 2 2 2 0 Jiraiya BORG_CEP PF14957.6 CDI82708.1 - 4.7 8.4 13.3 6.7 7.9 13.3 1.3 1 0 0 1 1 1 0 Cdc42 effector DUF2140 PF09911.9 CDI82708.1 - 4.9 6.7 18.0 0.028 14.0 7.9 1.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) CRA PF06589.11 CDI82708.1 - 5.4 7.1 8.8 2.8e+02 1.6 8.8 2.1 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) TMEM154 PF15102.6 CDI82708.1 - 6.7 6.6 9.3 0.2 11.6 1.6 2.0 1 1 1 2 2 2 0 TMEM154 protein family Peptidase_S49_N PF08496.10 CDI82708.1 - 7.4 6.6 22.1 13 5.8 22.1 1.5 1 1 0 1 1 1 0 Peptidase family S49 N-terminal HCO3_cotransp PF00955.21 CDI82708.1 - 7.5 5.2 8.4 8.7 5.0 8.4 1.2 1 0 0 1 1 1 0 HCO3- transporter family Velvet PF11754.8 CDI82708.1 - 8.9 6.2 20.6 11 5.9 20.6 1.1 1 0 0 1 1 1 0 Velvet factor Pkinase PF00069.25 CDI82712.1 - 9.3e-15 54.7 0.0 1.2e-07 31.3 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI82712.1 - 1.4e-11 44.2 0.0 1.2e-05 24.7 0.0 2.7 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CDI82712.1 - 2.1e-06 27.3 0.0 0.0059 16.0 0.0 2.3 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.22 CDI82712.1 - 0.0038 16.8 0.0 1.7 8.2 0.0 2.5 2 0 0 2 2 2 2 RIO1 family APH PF01636.23 CDI82712.1 - 0.19 11.7 6.6 16 5.3 0.0 4.2 4 1 1 5 5 5 0 Phosphotransferase enzyme family Radical_SAM PF04055.21 CDI82714.1 - 3.1e-12 47.2 0.0 3.5e-09 37.3 0.0 3.1 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 CDI82714.1 - 9.6e-06 25.7 0.0 0.00022 21.3 0.0 2.2 1 1 1 2 2 2 1 4Fe-4S single cluster domain RuBisCO_small PF00101.20 CDI82714.1 - 0.13 12.3 0.0 0.64 10.0 0.0 1.9 2 0 0 2 2 2 0 Ribulose bisphosphate carboxylase, small chain Dak2 PF02734.17 CDI82715.1 - 0.0017 18.3 3.6 0.0037 17.2 3.6 1.5 1 0 0 1 1 1 1 DAK2 domain IlvC PF01450.19 CDI82715.1 - 0.004 17.4 2.4 0.14 12.4 0.4 2.1 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain Secretin_N PF03958.17 CDI82715.1 - 0.039 14.3 3.1 2.5 8.6 1.0 2.6 1 1 1 2 2 2 0 Bacterial type II/III secretion system short domain DUF627 PF04781.12 CDI82715.1 - 0.052 13.6 0.9 12 6.0 0.1 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF627) Phe_tRNA-synt_N PF02912.18 CDI82715.1 - 0.2 11.6 6.0 5.9 6.9 0.1 3.0 3 0 0 3 3 3 0 Aminoacyl tRNA synthetase class II, N-terminal domain DUF2877 PF11392.8 CDI82715.1 - 0.23 12.2 3.0 1.4 9.6 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2877) ATP-synt_E PF05680.12 CDI82715.1 - 2.6 8.4 6.6 17 5.9 0.9 2.7 2 1 1 3 3 3 0 ATP synthase E chain NPA PF16469.5 CDI82715.1 - 2.8 8.6 9.8 49 4.5 9.8 2.6 1 1 0 1 1 1 0 Nematode polyprotein allergen ABA-1 Spt20 PF12090.8 CDI82730.1 - 0.0017 18.0 19.7 0.0017 18.0 19.7 6.6 4 1 1 5 5 5 3 Spt20 family Herpes_pp85 PF04637.12 CDI82730.1 - 6.9 5.0 18.3 1 7.7 4.3 2.5 2 0 0 2 2 2 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) RskA PF10099.9 CDI82732.1 - 2.3e-06 28.0 50.2 0.14 12.4 9.0 4.0 1 1 1 2 2 2 1 Anti-sigma-K factor rskA DUF2126 PF09899.9 CDI82732.1 - 0.0018 16.5 15.6 0.0018 16.5 15.6 2.0 2 1 0 2 2 2 1 Putative amidoligase enzyme (DUF2126) C2 PF00168.30 CDI82736.1 - 8.1e-14 51.8 0.0 2.2e-13 50.4 0.0 1.8 1 0 0 1 1 1 1 C2 domain WD40_alt PF14077.6 CDI82736.1 - 0.013 15.4 2.4 3.7 7.5 0.1 2.7 2 0 0 2 2 2 0 Alternative WD40 repeat motif AMOP PF03782.17 CDI82736.1 - 0.14 12.2 0.1 0.28 11.3 0.1 1.4 1 0 0 1 1 1 0 AMOP domain ABC_tran_CTD PF16326.5 CDI82736.1 - 1 9.7 6.8 3.1 8.1 6.8 1.8 1 1 0 1 1 1 0 ABC transporter C-terminal domain Siah-Interact_N PF09032.11 CDI82736.1 - 1.2 9.5 3.6 8.4 6.8 0.8 2.6 1 1 1 2 2 2 0 Siah interacting protein, N terminal DUF1192 PF06698.11 CDI82736.1 - 2.2 8.4 6.4 20 5.3 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) M PF02370.16 CDI82736.1 - 5.5 7.9 4.6 72 4.5 0.2 2.9 3 0 0 3 3 3 0 M protein repeat CD20 PF04103.15 CDI82739.1 - 0.1 12.7 0.2 0.1 12.7 0.2 2.7 2 1 0 2 2 2 0 CD20-like family RIFIN PF02009.16 CDI82739.1 - 1.8 8.4 30.2 2.4 7.9 30.2 1.3 1 0 0 1 1 1 0 Rifin MMR_HSR1 PF01926.23 CDI82740.1 - 1.7e-10 41.0 0.2 5.7e-10 39.3 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP1_OBG PF01018.22 CDI82740.1 - 0.00012 21.7 0.0 0.00012 21.7 0.0 2.4 2 1 0 2 2 2 1 GTP1/OBG AAA_21 PF13304.6 CDI82740.1 - 0.012 15.5 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system CDC45 PF02724.14 CDI82740.1 - 0.034 12.4 25.7 0.042 12.1 25.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2813 PF11398.8 CDI82740.1 - 0.22 10.7 0.0 0.22 10.7 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2813) SRP-alpha_N PF04086.13 CDI82740.1 - 0.38 10.6 28.6 0.56 10.1 28.6 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal AAA_23 PF13476.6 CDI82740.1 - 0.97 9.9 0.0 0.97 9.9 0.0 3.2 2 1 0 2 2 2 0 AAA domain RR_TM4-6 PF06459.12 CDI82740.1 - 2.8 7.7 32.9 5.7 6.7 32.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 CDI82740.1 - 5.8 4.9 33.8 7.7 4.5 33.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GAGA_bind PF06217.12 CDI82740.1 - 8.3 6.6 29.4 11 6.2 29.4 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family ASFV_J13L PF05568.11 CDI82742.1 - 0.024 14.4 1.6 0.024 14.4 1.6 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein Ribosomal_60s PF00428.19 CDI82742.1 - 1.1 9.9 8.7 1.9 9.1 8.7 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF2663 PF10864.8 CDI82743.1 - 0.0078 16.6 1.0 0.02 15.3 1.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2663) MSC PF09402.10 CDI82743.1 - 0.012 15.1 4.7 0.012 15.1 4.7 2.3 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain DUF3915 PF13054.6 CDI82743.1 - 0.023 14.7 1.1 0.023 14.7 1.1 3.7 4 1 0 4 4 4 0 Protein of unknown function (DUF3915) Synuclein PF01387.17 CDI82743.1 - 0.025 14.8 0.1 0.025 14.8 0.1 3.9 4 1 0 4 4 4 0 Synuclein CENP-B_dimeris PF09026.10 CDI82743.1 - 0.053 13.9 1.1 0.053 13.9 1.1 3.0 3 0 0 3 3 3 0 Centromere protein B dimerisation domain RskA PF10099.9 CDI82743.1 - 0.41 10.9 31.6 9.4 6.5 0.1 3.7 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI82743.1 - 0.72 8.7 67.0 0.35 9.8 27.4 2.5 2 0 0 2 2 2 0 Transcriptional activator LAG-3 DUF2076 PF09849.9 CDI82743.1 - 2.2 8.3 52.0 0.036 14.1 16.9 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2076) SLATT_6 PF18169.1 CDI82743.1 - 3.9 7.0 14.5 0.038 13.6 4.0 2.3 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 Mpp10 PF04006.12 CDI82745.1 - 1.3 7.4 29.2 1.4 7.3 29.2 1.0 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 CDI82745.1 - 1.8 6.7 28.5 2 6.5 28.5 1.0 1 0 0 1 1 1 0 Nop14-like family RNA_polI_A34 PF08208.11 CDI82745.1 - 1.9 8.5 22.7 2.3 8.2 22.7 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 CobT PF06213.12 CDI82745.1 - 3.7 6.9 31.1 4 6.7 31.1 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FGF-BP1 PF06473.12 CDI82745.1 - 3.9 7.2 18.3 4.2 7.1 18.3 1.0 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) BUD22 PF09073.10 CDI82745.1 - 4 6.7 24.9 4 6.7 24.9 1.0 1 0 0 1 1 1 0 BUD22 Connexin PF00029.19 CDI82745.1 - 4.3 7.0 12.0 6.1 6.5 12.0 1.3 1 0 0 1 1 1 0 Connexin Pox_Ag35 PF03286.14 CDI82745.1 - 4.6 7.0 25.7 6.9 6.4 25.7 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Presenilin PF01080.17 CDI82745.1 - 5.6 5.6 21.4 6.2 5.5 21.4 1.0 1 0 0 1 1 1 0 Presenilin TP53IP5 PF15331.6 CDI82745.1 - 6.7 6.8 15.2 7.7 6.6 15.2 1.0 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 CCSAP PF15748.5 CDI82745.1 - 7.3 6.7 22.5 7.4 6.7 22.5 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated FAM60A PF15396.6 CDI82745.1 - 8.3 6.3 10.4 9.3 6.2 10.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Vfa1 PF08432.10 CDI82745.1 - 8.9 6.6 20.8 9.9 6.4 20.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 CDI82745.1 - 9.8 5.9 27.4 11 5.8 27.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF883 PF05957.13 CDI82774.1 - 0.0069 17.0 3.7 0.0069 17.0 3.7 6.4 4 2 2 6 6 6 1 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 CDI82774.1 - 0.024 15.2 3.9 0.024 15.2 3.9 4.8 4 1 0 4 4 4 0 YtxH-like protein RskA PF10099.9 CDI82774.1 - 0.075 13.3 57.0 1.3 9.3 17.3 4.1 3 1 0 3 3 3 0 Anti-sigma-K factor rskA PAT1 PF09770.9 CDI82774.1 - 1.2 7.3 67.8 0.58 8.4 48.9 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SID-1_RNA_chan PF13965.6 CDI82774.1 - 8.5 4.7 22.3 4.2 5.7 0.9 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 XRN_N PF03159.18 CDI82775.1 - 3.7e-67 226.3 0.0 6.3e-67 225.5 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 CDI82775.1 - 2.8e-47 161.7 10.7 8.7e-17 61.2 3.8 4.3 4 0 0 4 4 4 4 Xrn1 helical domain SH3_12 PF18129.1 CDI82775.1 - 4.8e-06 26.6 0.0 0.0044 17.1 0.0 2.6 2 0 0 2 2 2 2 Xrn1 SH3-like domain FHA PF00498.26 CDI82777.1 - 0.059 13.7 0.0 0.2 12.0 0.0 1.9 2 0 0 2 2 2 0 FHA domain TMEM151 PF14857.6 CDI82779.1 - 0.13 11.2 1.0 0.23 10.4 1.0 1.3 1 0 0 1 1 1 0 TMEM151 family EF-hand_7 PF13499.6 CDI82781.1 - 3.5e-16 59.4 0.0 6.3e-08 33.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDI82781.1 - 1.6e-15 55.4 0.0 0.0069 15.8 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 CDI82781.1 - 2.1e-13 49.0 0.0 0.0021 17.8 0.0 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_9 PF14658.6 CDI82781.1 - 6.9e-09 35.9 0.0 0.00021 21.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 CDI82781.1 - 1.4e-07 31.2 0.0 0.6 10.0 0.0 4.1 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 CDI82781.1 - 1.9e-06 27.1 0.9 0.45 10.1 0.0 4.2 5 0 0 5 5 5 2 EF hand Beta_protein PF14350.6 CDI82781.1 - 0.014 14.8 0.0 0.016 14.7 0.0 1.0 1 0 0 1 1 1 0 Beta protein VIT1 PF01988.19 CDI82782.1 - 2.1e-56 191.2 0.5 2.7e-56 190.8 0.5 1.1 1 0 0 1 1 1 1 VIT family ABC2_membrane PF01061.24 CDI82782.1 - 2.1 7.7 8.8 2 7.8 4.5 2.2 2 0 0 2 2 2 0 ABC-2 type transporter DUF1700 PF08006.11 CDI82782.1 - 9.1 5.8 6.6 1.1e+02 2.2 6.6 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1700) SNF PF00209.18 CDI82783.1 - 1.5e-20 73.4 32.5 1.5e-20 73.4 32.5 2.4 2 1 0 2 2 2 2 Sodium:neurotransmitter symporter family WES_acyltransf PF03007.16 CDI82786.1 - 0.00032 20.6 0.0 0.0011 18.7 0.0 1.9 1 1 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain zf-ribbon_3 PF13248.6 CDI82786.1 - 0.076 12.5 1.1 0.2 11.1 1.1 1.8 1 0 0 1 1 1 0 zinc-ribbon domain DUF4407 PF14362.6 CDI82787.1 - 1.6e-05 24.5 5.8 2e-05 24.1 5.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF2722 PF10846.8 CDI82787.1 - 2.1e-05 23.7 8.8 2.2e-05 23.6 8.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Pex26 PF07163.12 CDI82787.1 - 0.00018 21.0 3.9 0.00022 20.7 3.9 1.1 1 0 0 1 1 1 1 Pex26 protein Suf PF05843.14 CDI82787.1 - 0.0006 19.9 2.4 0.0006 19.9 2.4 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Med15 PF09606.10 CDI82787.1 - 0.00068 18.5 11.0 0.0007 18.4 11.0 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF775 PF05603.12 CDI82787.1 - 0.0007 19.2 3.2 0.00086 18.9 3.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF775) TFIIA PF03153.13 CDI82787.1 - 0.0016 18.6 14.3 0.0017 18.5 14.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CDI82787.1 - 0.0098 16.3 0.4 0.012 16.0 0.4 1.2 1 0 0 1 1 1 1 Enhancer of polycomb-like LMBR1 PF04791.16 CDI82787.1 - 0.01 14.8 0.0 0.012 14.6 0.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein RskA PF10099.9 CDI82787.1 - 0.014 15.7 14.7 0.031 14.6 13.9 1.7 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DDHD PF02862.17 CDI82787.1 - 0.015 15.4 0.5 0.015 15.4 0.5 1.1 1 0 0 1 1 1 0 DDHD domain Ureide_permease PF07168.11 CDI82787.1 - 0.016 14.0 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Ureide permease Spt20 PF12090.8 CDI82787.1 - 0.017 14.7 22.7 0.022 14.4 22.7 1.1 1 0 0 1 1 1 0 Spt20 family Band_3_cyto PF07565.13 CDI82787.1 - 0.018 14.8 1.3 0.023 14.5 1.3 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF3464 PF11947.8 CDI82787.1 - 0.022 14.5 0.2 0.033 14.0 0.2 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Presenilin PF01080.17 CDI82787.1 - 0.042 12.6 1.5 0.044 12.6 1.5 1.1 1 0 0 1 1 1 0 Presenilin Otopetrin PF03189.13 CDI82787.1 - 0.044 12.6 0.1 0.054 12.3 0.1 1.1 1 0 0 1 1 1 0 Otopetrin INSIG PF07281.12 CDI82787.1 - 0.044 13.4 0.7 0.056 13.1 0.7 1.1 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) DUF2367 PF10164.9 CDI82787.1 - 0.063 13.8 0.1 0.12 12.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) FTCD_N PF07837.12 CDI82787.1 - 0.066 13.0 1.6 0.087 12.6 1.6 1.2 1 0 0 1 1 1 0 Formiminotransferase domain, N-terminal subdomain ArAE_2_N PF10337.9 CDI82787.1 - 0.1 11.6 2.6 0.13 11.3 2.6 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal TERB2 PF15101.6 CDI82787.1 - 0.11 12.5 7.3 0.15 12.1 7.3 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4199 PF13858.6 CDI82787.1 - 0.12 12.8 2.1 0.15 12.4 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Orf78 PF06024.12 CDI82787.1 - 0.12 12.7 0.1 0.2 12.0 0.1 1.4 1 0 0 1 1 1 0 Orf78 (ac78) DUF2417 PF10329.9 CDI82787.1 - 0.14 11.6 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 Region of unknown function (DUF2417) eIF-3_zeta PF05091.12 CDI82787.1 - 0.14 11.1 6.0 0.15 11.0 6.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SprA-related PF12118.8 CDI82787.1 - 0.14 11.2 14.5 0.17 11.0 14.5 1.1 1 0 0 1 1 1 0 SprA-related family baeRF_family10 PF18854.1 CDI82787.1 - 0.16 12.2 6.8 0.29 11.4 6.8 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 EIF4E-T PF10477.9 CDI82787.1 - 0.18 10.6 8.7 0.21 10.4 8.7 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E OATP PF03137.20 CDI82787.1 - 0.19 10.0 0.1 0.2 9.9 0.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family EIIBC-GUT_N PF03612.14 CDI82787.1 - 0.29 10.9 3.2 0.38 10.5 3.2 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus MscS_TM PF12794.7 CDI82787.1 - 0.31 9.9 6.9 0.41 9.4 6.9 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 MCU PF04678.13 CDI82787.1 - 0.41 10.7 4.5 0.55 10.3 4.5 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter UPF0560 PF10577.9 CDI82787.1 - 0.97 7.9 10.1 1.1 7.7 10.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Activator_LAG-3 PF11498.8 CDI82787.1 - 1.7 7.5 30.2 2.2 7.1 30.2 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 T2SSC PF11356.8 CDI82787.1 - 2.3 8.1 10.5 3.6 7.5 10.1 1.5 1 1 0 1 1 1 0 Type II secretion system protein C DivIC PF04977.15 CDI82787.1 - 3.2 7.6 14.2 5.7 6.8 14.2 1.4 1 0 0 1 1 1 0 Septum formation initiator DUF4834 PF16118.5 CDI82787.1 - 3.6 8.6 11.7 0.3 12.1 7.2 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF4834) Pex14_N PF04695.13 CDI82787.1 - 7 7.3 17.2 3.7 8.2 15.3 1.5 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF202 PF02656.15 CDI82794.1 - 7e-14 52.0 6.4 7e-14 52.0 6.4 5.0 5 1 0 5 5 5 1 Domain of unknown function (DUF202) VTC PF09359.10 CDI82794.1 - 9.4e-10 38.3 0.0 1.7e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 VTC domain TEX19 PF15553.6 CDI82794.1 - 7.1 6.6 7.2 0.54 10.2 1.0 2.3 2 0 0 2 2 2 0 Testis-expressed protein 19 MOZART1 PF12554.8 CDI82796.1 - 0.0033 17.2 0.2 0.0065 16.2 0.1 1.5 2 0 0 2 2 2 1 Mitotic-spindle organizing gamma-tubulin ring associated DEC-1_N PF04625.13 CDI82796.1 - 3.8 6.4 14.6 4 6.3 14.6 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DUF2526 PF10735.9 CDI82797.1 - 2.8 8.2 8.3 1.3 9.2 5.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2526) Paf1 PF03985.13 CDI82797.1 - 4.9 6.0 14.1 4.9 6.0 14.1 1.0 1 0 0 1 1 1 0 Paf1 Connexin PF00029.19 CDI82797.1 - 7.8 6.2 6.6 8.2 6.1 6.6 1.1 1 0 0 1 1 1 0 Connexin Macoilin PF09726.9 CDI82797.1 - 9.5 4.6 24.0 11 4.5 24.0 1.0 1 0 0 1 1 1 0 Macoilin family SRP-alpha_N PF04086.13 CDI82797.1 - 9.9 6.0 18.4 11 5.9 18.4 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RPOL_N PF14700.6 CDI82799.1 - 0.38 10.1 4.2 0.42 10.0 4.2 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal DUF1387 PF07139.11 CDI82799.1 - 0.45 10.2 19.3 0.55 9.9 19.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Tim54 PF11711.8 CDI82799.1 - 0.57 8.9 5.6 0.57 8.9 5.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 ALMT PF11744.8 CDI82799.1 - 2.7 6.7 21.2 3.2 6.5 21.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter HSP70 PF00012.20 CDI82803.1 - 0.12 10.5 16.6 0.12 10.5 16.6 1.1 1 0 0 1 1 1 0 Hsp70 protein Macoilin PF09726.9 CDI82803.1 - 0.4 9.2 26.1 0.72 8.3 26.1 1.6 1 0 0 1 1 1 0 Macoilin family FAM60A PF15396.6 CDI82803.1 - 3.3 7.7 31.2 5 7.1 31.2 1.3 1 0 0 1 1 1 0 Protein Family FAM60A CCSAP PF15748.5 CDI82803.1 - 8.7 6.4 43.9 19 5.3 43.9 1.6 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 CDI82803.1 - 9.3 5.1 40.7 12 4.8 40.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RskA PF10099.9 CDI82804.1 - 0.00013 22.3 2.5 0.00013 22.3 2.5 7.1 3 2 2 6 6 6 1 Anti-sigma-K factor rskA Miff PF05644.11 CDI82804.1 - 0.0026 17.4 16.9 0.0026 17.4 16.9 2.7 2 1 1 3 3 3 1 Mitochondrial and peroxisomal fission factor Mff Endostatin PF06482.11 CDI82804.1 - 0.15 11.5 29.4 1.2 8.5 3.9 2.5 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin SpoIIIAH PF12685.7 CDI82804.1 - 1.7 8.4 27.2 1.1 9.1 13.3 2.6 2 0 0 2 2 2 0 SpoIIIAH-like protein AAA_11 PF13086.6 CDI82804.1 - 3 7.6 25.8 5.7 6.6 17.2 2.2 2 0 0 2 2 2 0 AAA domain Lin-8 PF03353.15 CDI82804.1 - 3.4 7.2 47.6 0.032 13.8 22.8 2.7 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist Exonuc_VII_L PF02601.15 CDI82804.1 - 3.5 7.1 28.7 13 5.2 3.5 2.9 3 0 0 3 3 3 0 Exonuclease VII, large subunit PAP2 PF01569.21 CDI82813.1 - 0.084 12.6 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 PAP2 superfamily DUF733 PF05306.11 CDI82813.1 - 2.1 8.7 6.9 4 7.8 6.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF733) CDC27 PF09507.10 CDI82813.1 - 2.9 7.2 12.0 3.7 6.8 12.0 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 TFIIA PF03153.13 CDI82813.1 - 9.4 6.1 20.3 11 5.9 20.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAP1 PF08601.10 CDI82815.1 - 2.2e-05 24.4 17.1 2.7e-05 24.1 17.1 1.1 1 0 0 1 1 1 1 Transcription factor PAP1 Caprin-1_dimer PF18293.1 CDI82815.1 - 0.0017 18.8 1.5 0.0037 17.8 1.5 1.5 1 0 0 1 1 1 1 Caprin-1 dimerization domain SYF2 PF08231.12 CDI82815.1 - 0.11 12.9 3.0 0.36 11.2 2.1 2.0 2 0 0 2 2 2 0 SYF2 splicing factor Peptidase_S64 PF08192.11 CDI82815.1 - 0.58 8.6 13.7 0.65 8.4 13.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 SR-25 PF10500.9 CDI82815.1 - 2 8.0 41.5 0.021 14.5 19.5 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Tmemb_cc2 PF10267.9 CDI82815.1 - 2.3 7.3 13.8 2.8 7.0 13.8 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Nucleo_P87 PF07267.11 CDI82815.1 - 2.6 6.8 7.8 3 6.6 7.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SOBP PF15279.6 CDI82815.1 - 4.1 7.9 16.2 5.8 7.4 16.2 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Hamartin PF04388.12 CDI82815.1 - 8.8 4.9 16.1 10 4.6 16.1 1.2 1 0 0 1 1 1 0 Hamartin protein RIC3 PF15361.6 CDI82817.1 - 0.0017 18.8 0.1 0.0017 18.8 0.1 10.8 6 3 0 6 6 6 1 Resistance to inhibitors of cholinesterase homologue 3 CCSAP PF15748.5 CDI82818.1 - 0.0019 18.4 85.1 0.0033 17.6 49.4 2.2 2 0 0 2 2 2 2 Centriole, cilia and spindle-associated SRP-alpha_N PF04086.13 CDI82818.1 - 0.18 11.7 63.7 0.06 13.3 12.9 2.3 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal BAF1_ABF1 PF04684.13 CDI82818.1 - 0.27 10.2 64.5 0.3 10.1 37.1 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor PAT1 PF09770.9 CDI82818.1 - 0.65 8.2 124.5 0.051 11.8 72.4 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Raftlin PF15250.6 CDI82818.1 - 1.4 7.6 64.1 1.9 7.1 17.2 2.1 2 0 0 2 2 2 0 Raftlin Cwf_Cwc_15 PF04889.12 CDI82818.1 - 1.9 8.2 66.4 0.017 14.9 11.0 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CBF PF03914.17 CDI82819.1 - 5.4e-06 26.6 0.6 1e-05 25.6 0.6 1.5 1 0 0 1 1 1 1 CBF/Mak21 family RskA PF10099.9 CDI82819.1 - 0.019 15.3 7.5 0.019 15.3 7.5 3.5 1 1 2 3 3 3 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI82819.1 - 0.13 12.3 33.3 0.16 12.0 33.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CRT10 PF08728.10 CDI82820.1 - 7.8 4.5 28.1 0.72 7.9 16.4 2.3 2 0 0 2 2 2 0 CRT10 WDCP PF15390.6 CDI82821.1 - 0.075 11.4 3.5 0.095 11.1 3.5 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Spt20 PF12090.8 CDI82821.1 - 0.73 9.4 14.3 1.1 8.8 14.3 1.2 1 0 0 1 1 1 0 Spt20 family Activator_LAG-3 PF11498.8 CDI82821.1 - 2.8 6.8 22.8 3.9 6.3 22.8 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SID-1_RNA_chan PF13965.6 CDI82823.1 - 0.087 11.2 8.0 0.089 11.2 8.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Connexin PF00029.19 CDI82823.1 - 0.42 10.3 13.0 0.44 10.3 13.0 1.2 1 0 0 1 1 1 0 Connexin MCM_bind PF09739.9 CDI82823.1 - 0.48 8.8 21.1 0.47 8.8 21.1 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF1980 PF09323.10 CDI82823.1 - 0.56 10.1 12.8 0.57 10.1 12.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Miga PF10265.9 CDI82823.1 - 0.58 9.1 11.9 0.66 8.9 11.9 1.1 1 0 0 1 1 1 0 Mitoguardin Paf1 PF03985.13 CDI82823.1 - 0.58 9.1 22.4 0.55 9.2 22.4 1.1 1 0 0 1 1 1 0 Paf1 EIF4E-T PF10477.9 CDI82823.1 - 0.6 8.9 24.9 0.65 8.7 24.9 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E TFB6 PF17110.5 CDI82823.1 - 0.67 9.7 9.0 0.67 9.7 9.0 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH SelP_N PF04592.14 CDI82823.1 - 0.85 9.0 18.5 0.97 8.8 18.5 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Band_3_cyto PF07565.13 CDI82823.1 - 0.85 9.4 17.1 0.83 9.4 17.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain NEMP PF10225.9 CDI82823.1 - 1.3 8.7 8.2 1.5 8.4 8.2 1.1 1 0 0 1 1 1 0 NEMP family eIF-3_zeta PF05091.12 CDI82823.1 - 1.3 7.9 28.5 1.3 7.9 28.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Serinc PF03348.15 CDI82823.1 - 1.4 7.7 14.9 1.6 7.6 14.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2828 PF11443.8 CDI82823.1 - 1.6 6.8 21.5 1.5 6.8 21.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Peptidase_S49_N PF08496.10 CDI82823.1 - 1.8 8.6 15.9 2.2 8.3 15.9 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal V_ATPase_I PF01496.19 CDI82823.1 - 2 6.3 19.8 1.7 6.4 19.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2232 PF09991.9 CDI82823.1 - 2.3 7.3 6.3 3 6.9 6.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) F-protein PF00469.20 CDI82823.1 - 2.9 7.4 14.6 2.8 7.5 14.6 1.2 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef TFIIA PF03153.13 CDI82823.1 - 4.1 7.3 53.6 4.6 7.1 53.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM199X PF15814.5 CDI82823.1 - 4.4 6.3 21.6 5.7 5.9 21.6 1.1 1 0 0 1 1 1 0 Protein family FAM199X Velvet PF11754.8 CDI82823.1 - 4.8 7.0 23.9 5.6 6.8 23.9 1.2 1 0 0 1 1 1 0 Velvet factor CSG2 PF16965.5 CDI82823.1 - 5.1 5.9 12.1 4.8 6.0 12.1 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator O-antigen_lig PF13425.6 CDI82823.1 - 5.5 5.7 9.2 5.8 5.6 9.2 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Activator_LAG-3 PF11498.8 CDI82823.1 - 6 5.7 49.3 8.2 5.3 49.3 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF913 PF06025.12 CDI82823.1 - 6.1 5.7 17.1 6.9 5.5 17.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 CDI82823.1 - 6.6 6.7 19.2 8.1 6.4 19.2 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Peptidase_S64 PF08192.11 CDI82823.1 - 6.7 5.1 17.0 6.4 5.1 17.0 1.2 1 0 0 1 1 1 0 Peptidase family S64 DDHD PF02862.17 CDI82823.1 - 7.1 6.7 23.4 8.8 6.4 23.4 1.2 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.14 CDI82823.1 - 7.3 4.8 19.2 7.1 4.8 19.2 1.1 1 0 0 1 1 1 0 CDC45-like protein AAT PF03417.16 CDI82823.1 - 8.9 5.9 16.4 11 5.7 16.4 1.1 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase BAF1_ABF1 PF04684.13 CDI82823.1 - 9.1 5.2 27.6 12 4.8 27.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor AF-4 PF05110.13 CDI82823.1 - 9.1 4.2 30.9 9.9 4.1 30.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4813 PF16072.5 CDI82824.1 - 6 6.5 29.9 10 5.7 29.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) CDC45 PF02724.14 CDI82834.1 - 1.1 7.5 28.8 1 7.6 12.2 2.4 2 0 0 2 2 2 0 CDC45-like protein ASC PF00858.24 CDI82834.1 - 2.1 7.2 13.6 1.5 7.7 1.6 2.2 2 0 0 2 2 2 0 Amiloride-sensitive sodium channel CNDH2_C PF16858.5 CDI82834.1 - 6.8 6.5 37.1 0.9 9.4 11.6 2.4 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SpoIIP PF07454.11 CDI82834.1 - 9.6 5.6 44.4 0.11 12.0 14.9 3.0 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) TMEM65 PF10507.9 CDI82837.1 - 1.9e-06 27.7 0.4 1.9e-06 27.7 0.4 3.6 3 1 2 5 5 5 1 Transmembrane protein 65 RskA PF10099.9 CDI82837.1 - 0.00095 19.5 2.7 0.00095 19.5 2.7 5.7 3 2 1 4 4 4 2 Anti-sigma-K factor rskA Kinase-like PF14531.6 CDI82847.1 - 0.0003 20.2 0.0 0.00061 19.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.25 CDI82847.1 - 0.076 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Hen1_L PF12623.7 CDI82847.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 RNA repair, ligase-Pnkp-associating, region of Hen1 Na_H_Exchanger PF00999.21 CDI82848.1 - 0.015 14.1 0.1 0.015 14.1 0.1 1.9 2 0 0 2 2 2 0 Sodium/hydrogen exchanger family Chromo PF00385.24 CDI82849.1 - 2.3e-15 56.2 0.0 3.9e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RVT_1 PF00078.27 CDI82850.1 - 2.3e-18 66.5 0.0 4.3e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 CDI82850.1 - 2.8e-13 49.7 0.5 5.3e-13 48.9 0.5 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 CDI82850.1 - 2.3e-05 24.6 0.0 6e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDI82850.1 - 4.1e-05 23.6 0.0 8.8e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDI82850.1 - 0.00016 21.9 0.0 0.00038 20.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 CDI82850.1 - 0.0092 16.2 0.6 0.019 15.2 0.6 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Phage_Gp15 PF06854.11 CDI82855.1 - 4.7 7.2 12.3 5.8 6.9 12.3 1.1 1 0 0 1 1 1 0 Bacteriophage Gp15 protein RcpC PF16976.5 CDI82855.1 - 9.9 6.3 10.0 14 5.7 10.0 1.4 1 1 0 1 1 1 0 Flp pilus assembly protein RcpC/CpaB DUF4834 PF16118.5 CDI82858.1 - 0.012 16.5 4.7 0.37 11.8 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Secretin_N_2 PF07655.13 CDI82858.1 - 0.021 15.3 12.5 0.021 15.3 12.5 1.8 2 0 0 2 2 2 0 Secretin N-terminal domain Presenilin PF01080.17 CDI82858.1 - 0.16 10.7 3.8 0.18 10.6 3.8 1.1 1 0 0 1 1 1 0 Presenilin CNDH2_M PF16869.5 CDI82858.1 - 9.4 6.9 13.0 9.2 6.9 5.3 2.0 2 0 0 2 2 2 0 PF16858 Rep_fac_C PF08542.11 CDI82882.1 - 1.6e-11 44.4 0.0 4.9e-11 42.9 0.0 1.6 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA_assoc_2 PF16193.5 CDI82882.1 - 0.00034 20.9 0.0 0.00052 20.3 0.0 1.4 1 0 0 1 1 1 1 AAA C-terminal domain SUIM_assoc PF16619.5 CDI82886.1 - 0.00022 21.2 0.0 0.00022 21.2 0.0 14.8 6 4 2 8 8 8 3 Unstructured region C-term to UIM in Ataxin3 DUF755 PF05501.11 CDI82886.1 - 0.016 15.5 7.8 0.016 15.5 7.8 10.6 8 2 1 9 9 9 0 Domain of unknown function (DUF755) PAT1 PF09770.9 CDI82898.1 - 0.013 13.8 13.8 0.014 13.7 13.8 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CLN3 PF02487.17 CDI82898.1 - 0.079 12.0 3.4 0.12 11.4 3.4 1.3 1 0 0 1 1 1 0 CLN3 protein MCM_bind PF09739.9 CDI82898.1 - 0.08 11.4 8.3 0.14 10.6 8.3 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Connexin PF00029.19 CDI82898.1 - 0.26 11.0 6.2 0.46 10.2 6.2 1.3 1 0 0 1 1 1 0 Connexin eIF-3_zeta PF05091.12 CDI82898.1 - 0.83 8.6 10.3 1.1 8.1 10.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ALMT PF11744.8 CDI82898.1 - 3.4 6.4 6.6 4.6 6.0 6.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter MDM10 PF12519.8 CDI82898.1 - 3.9 6.2 10.4 6.5 5.5 10.4 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 UPF0560 PF10577.9 CDI82898.1 - 4.1 5.8 18.5 6.7 5.1 18.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 RNA_pol_Rpc4 PF05132.14 CDI82898.1 - 4.9 7.6 0.0 4.9 7.6 0.0 4.3 4 1 0 4 4 4 0 RNA polymerase III RPC4 OATP PF03137.20 CDI82898.1 - 6.1 5.0 5.8 9.1 4.4 5.8 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 CDI82899.1 - 4e-23 81.9 34.2 4e-23 81.9 34.2 2.3 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF908 PF06012.12 CDI82899.1 - 0.12 11.7 3.0 1.1 8.7 0.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) W2 PF02020.18 CDI82901.1 - 0.12 12.6 0.4 1.2 9.4 0.0 2.0 2 0 0 2 2 2 0 eIF4-gamma/eIF5/eIF2-epsilon Spt20 PF12090.8 CDI82904.1 - 0.02 14.5 32.9 0.024 14.3 32.9 1.1 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI82904.1 - 0.025 14.6 38.8 0.029 14.4 38.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit UNC-79 PF14776.6 CDI82904.1 - 0.04 12.7 3.2 0.037 12.8 3.2 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 DUF5392 PF17370.2 CDI82904.1 - 0.054 13.6 2.6 0.067 13.3 2.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5392) FHIPEP PF00771.20 CDI82904.1 - 0.084 11.3 13.2 0.089 11.2 13.2 1.1 1 0 0 1 1 1 0 FHIPEP family AAA_23 PF13476.6 CDI82904.1 - 0.1 13.1 12.7 0.095 13.2 12.7 1.1 1 0 0 1 1 1 0 AAA domain Connexin PF00029.19 CDI82904.1 - 0.13 12.0 5.2 0.13 12.0 5.2 1.2 1 0 0 1 1 1 0 Connexin eIF-3_zeta PF05091.12 CDI82904.1 - 0.15 11.0 15.1 0.15 11.0 15.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SID-1_RNA_chan PF13965.6 CDI82904.1 - 0.18 10.2 2.6 0.17 10.2 2.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Band_3_cyto PF07565.13 CDI82904.1 - 0.23 11.2 7.1 0.22 11.3 7.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4667 PF15700.5 CDI82904.1 - 0.31 11.1 10.3 0.32 11.1 10.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) V_ATPase_I PF01496.19 CDI82904.1 - 0.34 8.8 9.5 0.29 9.0 9.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4820 PF16091.5 CDI82904.1 - 0.43 9.9 14.9 0.49 9.7 14.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) CLN3 PF02487.17 CDI82904.1 - 0.55 9.2 6.4 0.52 9.3 6.4 1.2 1 0 0 1 1 1 0 CLN3 protein CSG2 PF16965.5 CDI82904.1 - 0.59 9.0 4.1 0.54 9.2 4.1 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Glt_symporter PF03616.14 CDI82904.1 - 0.69 8.5 5.5 0.8 8.3 5.5 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter PA26 PF04636.13 CDI82904.1 - 0.77 8.6 11.4 0.77 8.6 11.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SpoIIP PF07454.11 CDI82904.1 - 0.77 9.2 12.8 0.82 9.1 12.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Coilin_N PF15862.5 CDI82904.1 - 0.82 9.5 13.1 1.2 9.0 13.1 1.3 1 0 0 1 1 1 0 Coilin N-terminus DDHD PF02862.17 CDI82904.1 - 0.83 9.8 13.5 0.9 9.7 13.5 1.2 1 0 0 1 1 1 0 DDHD domain Suf PF05843.14 CDI82904.1 - 0.98 9.3 21.7 1.2 9.0 21.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Med15 PF09606.10 CDI82904.1 - 1.1 7.9 29.7 1.3 7.7 29.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF1980 PF09323.10 CDI82904.1 - 1.3 8.9 7.0 1.3 8.9 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Neur_chan_memb PF02932.16 CDI82904.1 - 1.3 9.0 10.2 1.4 8.9 10.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region THOC2_N PF16134.5 CDI82904.1 - 1.6 7.3 16.2 1.9 7.0 16.2 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus FAM60A PF15396.6 CDI82904.1 - 1.6 8.7 11.5 1.7 8.6 11.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A 2HCT PF03390.15 CDI82904.1 - 1.7 7.2 6.4 2 7.0 6.4 1.1 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family MMR1 PF08505.10 CDI82904.1 - 1.7 8.9 14.3 1.7 8.9 14.3 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF913 PF06025.12 CDI82904.1 - 1.9 7.4 8.7 2 7.3 8.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2232 PF09991.9 CDI82904.1 - 2.1 7.5 4.5 2.3 7.3 4.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) TMEM174 PF15029.6 CDI82904.1 - 2.3 7.9 6.2 2.5 7.7 6.2 1.1 1 0 0 1 1 1 0 Transmembrane protein 174 Ureide_permease PF07168.11 CDI82904.1 - 2.6 6.7 7.2 3.1 6.5 7.2 1.2 1 0 0 1 1 1 0 Ureide permease O-antigen_lig PF13425.6 CDI82904.1 - 2.8 6.6 3.0 2.9 6.6 3.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DcuA_DcuB PF03605.14 CDI82904.1 - 2.9 6.7 11.3 3.3 6.5 11.3 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF572 PF04502.13 CDI82904.1 - 3.2 7.3 16.1 3.5 7.2 16.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Serinc PF03348.15 CDI82904.1 - 3.2 6.6 8.4 3.2 6.6 8.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) OATP PF03137.20 CDI82904.1 - 3.2 5.9 7.7 3.7 5.7 7.7 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Myc_N PF01056.18 CDI82904.1 - 3.7 7.4 13.7 4.1 7.2 13.7 1.1 1 0 0 1 1 1 0 Myc amino-terminal region PAT1 PF09770.9 CDI82904.1 - 4.3 5.5 27.3 4.5 5.4 27.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Sec62 PF03839.16 CDI82904.1 - 4.5 6.7 9.1 4.6 6.7 9.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 NEMP PF10225.9 CDI82904.1 - 5.9 6.5 5.5 6.8 6.3 5.5 1.1 1 0 0 1 1 1 0 NEMP family Presenilin PF01080.17 CDI82904.1 - 6.1 5.5 19.7 6.3 5.5 19.7 1.0 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI82904.1 - 6.7 6.5 17.0 6.9 6.4 17.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Bac_luciferase PF00296.20 CDI82904.1 - 6.8 6.0 32.5 8.1 5.8 32.5 1.0 1 0 0 1 1 1 0 Luciferase-like monooxygenase EphA2_TM PF14575.6 CDI82904.1 - 7.6 7.5 9.0 17 6.4 9.0 1.6 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain FliP PF00813.20 CDI82904.1 - 7.7 6.4 5.7 7.6 6.4 5.7 1.2 1 0 0 1 1 1 0 FliP family PigN PF04987.14 CDI82904.1 - 8.9 5.0 5.6 9.3 5.0 5.6 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) GAGA_bind PF06217.12 CDI82904.1 - 9.9 6.4 16.4 11 6.2 16.4 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family TFIIA PF03153.13 CDI82906.1 - 0.037 14.0 26.1 0.042 13.9 26.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI82906.1 - 0.59 10.1 6.2 0.75 9.7 6.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Herpes_IE1 PF07340.11 CDI82906.1 - 0.67 8.8 3.5 0.95 8.3 3.5 1.2 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein Endomucin PF07010.12 CDI82906.1 - 0.87 9.5 24.2 1.1 9.1 24.2 1.3 1 0 0 1 1 1 0 Endomucin JCAD PF15351.6 CDI82906.1 - 5.4 4.6 13.0 1.5 6.5 10.3 1.3 1 1 0 1 1 1 0 Junctional protein associated with coronary artery disease Utp14 PF04615.13 CDI82906.1 - 9.2 4.7 15.3 11 4.4 15.3 1.0 1 0 0 1 1 1 0 Utp14 protein RRM_1 PF00076.22 CDI82909.1 - 5.9e-07 29.2 1.5 8.5e-07 28.7 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rtf2 PF04641.12 CDI82909.1 - 0.01 15.2 4.2 0.013 14.9 4.2 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Macoilin PF09726.9 CDI82909.1 - 0.015 13.9 8.9 0.015 13.9 8.9 1.2 1 0 0 1 1 1 0 Macoilin family DUF572 PF04502.13 CDI82909.1 - 0.045 13.4 7.0 0.053 13.1 7.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) BAF1_ABF1 PF04684.13 CDI82909.1 - 0.14 11.1 13.7 0.36 9.8 11.3 1.9 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Menin PF05053.13 CDI82909.1 - 0.57 8.5 9.7 0.63 8.3 9.7 1.1 1 0 0 1 1 1 0 Menin SAPS PF04499.15 CDI82909.1 - 1.4 7.6 7.9 1.7 7.3 7.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Smg8_Smg9 PF10220.9 CDI82909.1 - 1.5 7.0 9.5 2.2 6.5 9.5 1.2 1 0 0 1 1 1 0 Smg8_Smg9 Hid1 PF12722.7 CDI82909.1 - 5.3 5.0 7.3 7 4.6 7.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4820 PF16091.5 CDI82909.1 - 7.4 5.9 9.0 13 5.0 9.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) GREB1 PF15782.5 CDI82918.1 - 1.9 5.5 45.4 2.3 5.2 45.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PAT1 PF09770.9 CDI82918.1 - 4 5.6 55.7 5.3 5.2 55.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4079 PF13301.6 CDI82920.1 - 3.7e-06 27.1 0.0 2.4 8.3 0.3 4.5 4 1 0 4 4 4 3 Protein of unknown function (DUF4079) TMEM154 PF15102.6 CDI82927.1 - 0.00061 19.7 2.4 0.00061 19.7 2.4 5.5 1 1 2 4 4 4 1 TMEM154 protein family Conotoxin PF02950.17 CDI82927.1 - 0.0025 18.8 1.5 0.0025 18.8 1.5 8.8 2 1 1 3 3 3 1 Conotoxin DUF4834 PF16118.5 CDI82927.1 - 0.024 15.6 5.3 0.024 15.6 5.3 8.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 CDI82927.1 - 0.1 13.5 0.5 0.1 13.5 0.5 8.5 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain GRP PF07172.11 CDI82927.1 - 0.2 12.4 0.1 0.2 12.4 0.1 6.9 2 1 2 4 4 4 0 Glycine rich protein family DUF4775 PF16001.5 CDI82928.1 - 0.072 12.5 25.5 0.097 12.1 25.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) CCSAP PF15748.5 CDI82928.1 - 0.1 12.8 50.3 0.13 12.4 50.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated LMBR1 PF04791.16 CDI82928.1 - 0.1 11.5 18.3 0.16 10.8 18.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 CDI82928.1 - 0.47 10.0 32.1 0.71 9.4 32.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Utp14 PF04615.13 CDI82928.1 - 1.4 7.4 37.1 1.7 7.1 37.1 1.0 1 0 0 1 1 1 0 Utp14 protein DUF4045 PF13254.6 CDI82928.1 - 3.6 7.1 34.9 5.8 6.5 34.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF5523 PF17661.1 CDI82928.1 - 4.3 7.0 37.9 7.3 6.2 37.9 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5523) SWI-SNF_Ssr4 PF08549.10 CDI82928.1 - 4.9 5.7 38.2 5.7 5.4 38.2 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) RskA PF10099.9 CDI82929.1 - 0.056 13.7 59.5 7.6 6.8 28.7 5.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA YitT_membrane PF02588.15 CDI82929.1 - 2.8 7.3 3.6 4.5 6.6 3.6 1.2 1 0 0 1 1 1 0 Uncharacterised 5xTM membrane BCR, YitT family COG1284 Halogen_Hydrol PF10112.9 CDI82944.1 - 0.00033 20.7 0.7 0.00033 20.7 0.7 2.1 2 0 0 2 2 2 1 5-bromo-4-chloroindolyl phosphate hydrolysis protein SUIM_assoc PF16619.5 CDI82944.1 - 0.0017 18.4 2.5 0.0017 18.4 2.5 2.6 2 2 0 2 2 1 1 Unstructured region C-term to UIM in Ataxin3 Ribosomal_60s PF00428.19 CDI82944.1 - 0.0049 17.4 3.9 0.0049 17.4 3.9 1.9 2 0 0 2 2 2 1 60s Acidic ribosomal protein RskA PF10099.9 CDI82944.1 - 0.0053 17.1 5.1 0.0053 17.1 5.1 1.9 2 0 0 2 2 2 1 Anti-sigma-K factor rskA DUF521 PF04412.13 CDI82944.1 - 0.26 10.0 2.7 0.13 10.9 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF521) DUF2072 PF09845.9 CDI82944.1 - 0.41 10.9 7.1 6.5 7.0 1.6 2.3 2 0 0 2 2 2 0 Zn-ribbon containing protein DNA_primase_lrg PF04104.14 CDI82944.1 - 0.63 9.4 5.0 0.11 11.8 0.6 1.8 2 0 0 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit OAD_gamma PF04277.13 CDI82944.1 - 4.6 7.9 7.6 7.7 7.2 0.9 2.9 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain AAA_23 PF13476.6 CDI82944.1 - 6.5 7.2 17.2 9.7 6.6 7.0 2.1 2 0 0 2 2 2 0 AAA domain Mem_trans PF03547.18 CDI82944.1 - 9.7 4.5 5.6 3.8 5.8 0.1 2.0 2 0 0 2 2 2 0 Membrane transport protein Ureide_permease PF07168.11 CDI82944.1 - 9.7 4.8 6.5 4.6 5.9 0.2 2.0 2 0 0 2 2 2 0 Ureide permease DUF2722 PF10846.8 CDI82958.1 - 0.0025 16.9 5.5 0.0025 16.9 5.5 3.4 3 0 0 3 3 3 1 Protein of unknown function (DUF2722) DUF3464 PF11947.8 CDI82958.1 - 0.013 15.2 9.7 0.013 15.2 9.7 3.3 2 1 1 3 3 3 0 Photosynthesis affected mutant 68 RskA PF10099.9 CDI82958.1 - 0.018 15.4 11.4 0.018 15.4 11.4 4.1 1 1 2 3 3 2 0 Anti-sigma-K factor rskA Afi1 PF07792.12 CDI82958.1 - 0.042 14.3 25.0 0.33 11.4 11.6 3.1 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking EphA2_TM PF14575.6 CDI82958.1 - 0.08 13.8 0.3 0.08 13.8 0.3 3.9 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Rxt3 PF08642.10 CDI82958.1 - 0.18 12.6 16.9 13 6.5 0.3 3.3 3 0 0 3 3 3 0 Histone deacetylation protein Rxt3 SpoIIP PF07454.11 CDI82958.1 - 0.32 10.4 29.7 0.65 9.4 11.6 3.1 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) Trp_oprn_chp PF09534.10 CDI82958.1 - 0.44 10.3 44.0 0.053 13.3 6.7 3.2 2 1 1 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) FmiP_Thoc5 PF09766.9 CDI82958.1 - 0.58 9.4 32.8 0.96 8.7 13.2 3.1 3 0 0 3 3 3 0 Fms-interacting protein/Thoc5 SARAF PF06682.12 CDI82958.1 - 0.62 9.6 31.3 0.46 10.1 9.3 3.1 2 1 1 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis TERB2 PF15101.6 CDI82958.1 - 0.66 10.0 45.6 3.3 7.7 4.4 3.1 3 0 0 3 3 3 0 Telomere-associated protein TERB2 PRP1_N PF06424.12 CDI82958.1 - 1.6 9.1 25.5 2.8 8.3 0.7 3.3 3 0 0 3 3 3 0 PRP1 splicing factor, N-terminal SURF2 PF05477.11 CDI82958.1 - 1.8 8.2 26.5 0.42 10.3 18.6 2.3 2 1 0 2 2 2 0 Surfeit locus protein 2 (SURF2) Activator_LAG-3 PF11498.8 CDI82958.1 - 2 7.3 105.8 0.0087 15.1 43.0 3.1 3 0 0 3 3 3 0 Transcriptional activator LAG-3 EPL1 PF10513.9 CDI82958.1 - 2 8.8 33.8 1.2 9.6 11.4 3.3 3 0 0 3 3 3 0 Enhancer of polycomb-like PH_4 PF15404.6 CDI82958.1 - 3.1 7.6 23.3 2.6 7.8 7.9 3.1 3 0 0 3 3 3 0 Pleckstrin homology domain DUF4820 PF16091.5 CDI82958.1 - 3.8 6.8 27.6 4.3 6.6 1.4 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4820) RNase_H2_suC PF08615.11 CDI82958.1 - 4.9 7.3 21.1 6.1 7.0 1.1 3.2 3 0 0 3 3 3 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) MPM1 PF17234.2 CDI82958.1 - 6.6 7.0 36.1 9.6 6.4 5.1 3.3 3 0 0 3 3 3 0 Mitochondrial peculiar membrane protein 1 PEX11 PF05648.14 CDI82958.1 - 6.8 6.1 20.5 0.82 9.1 0.6 3.2 3 0 0 3 3 3 0 Peroxisomal biogenesis factor 11 (PEX11) Peptidase_S64 PF08192.11 CDI82958.1 - 7.1 5.0 31.2 0.5 8.8 22.3 2.0 2 0 0 2 2 2 0 Peptidase family S64 Ureide_permease PF07168.11 CDI82958.1 - 7.3 5.2 14.8 1.4 7.6 3.7 3.1 3 0 0 3 3 3 0 Ureide permease MCU PF04678.13 CDI82958.1 - 7.9 6.5 24.6 1.3 9.0 8.0 3.2 3 0 0 3 3 3 0 Mitochondrial calcium uniporter AIF_C PF14721.6 CDI82958.1 - 8.4 6.8 26.3 12 6.3 0.5 3.4 3 0 0 3 3 3 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CRAL_TRIO PF00650.20 CDI82960.1 - 0.00047 19.9 0.0 0.00065 19.5 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Neuregulin PF02158.15 CDI82962.1 - 0.023 14.1 9.7 0.03 13.7 9.7 1.3 1 0 0 1 1 1 0 Neuregulin intracellular region RNase_H2_suC PF08615.11 CDI82962.1 - 0.045 13.9 7.6 0.17 12.1 2.7 2.2 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) SARAF PF06682.12 CDI82962.1 - 0.049 13.3 11.9 0.061 13.0 11.9 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis V_ATPase_I PF01496.19 CDI82962.1 - 0.071 11.0 9.3 0.091 10.7 9.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CD20 PF04103.15 CDI82962.1 - 0.091 12.8 0.2 0.091 12.8 0.2 1.6 1 1 1 2 2 2 0 CD20-like family DDHD PF02862.17 CDI82962.1 - 0.097 12.8 12.0 0.13 12.4 12.0 1.3 1 0 0 1 1 1 0 DDHD domain Rgp1 PF08737.10 CDI82962.1 - 0.12 11.5 16.4 0.14 11.3 16.4 1.0 1 0 0 1 1 1 0 Rgp1 DUF4820 PF16091.5 CDI82962.1 - 0.14 11.5 14.2 0.18 11.1 14.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF2828 PF11443.8 CDI82962.1 - 0.14 10.2 11.1 0.14 10.2 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) 7tm_1 PF00001.21 CDI82962.1 - 0.37 10.1 2.1 0.48 9.7 2.1 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) SID-1_RNA_chan PF13965.6 CDI82962.1 - 0.48 8.8 5.9 0.56 8.5 5.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Hen1_Lam_C PF18441.1 CDI82962.1 - 0.54 10.1 2.6 0.5 10.2 1.1 1.7 1 1 1 2 2 2 0 Hen1 La-motif C-terminal domain FHIPEP PF00771.20 CDI82962.1 - 0.61 8.5 15.4 0.9 7.9 15.4 1.3 1 1 0 1 1 1 0 FHIPEP family Serinc PF03348.15 CDI82962.1 - 1.3 7.9 6.0 1.5 7.7 6.0 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) UPF0542 PF15086.6 CDI82962.1 - 1.7 8.7 0.0 1.7 8.7 0.0 3.5 3 1 0 3 3 2 0 Uncharacterised protein family UPF0542 ArsP_1 PF03773.13 CDI82962.1 - 1.8 7.6 4.8 31 3.6 4.8 2.0 1 1 0 1 1 1 0 Predicted permease RNA_pol_Rbc25 PF08292.12 CDI82962.1 - 2.3 8.4 10.1 6.5 7.0 5.7 2.3 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 Trp_oprn_chp PF09534.10 CDI82962.1 - 2.4 7.9 8.4 2.5 7.9 7.5 1.5 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PAT1 PF09770.9 CDI82962.1 - 3.1 6.0 30.3 4.3 5.5 30.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TMEM154 PF15102.6 CDI82962.1 - 3.1 7.7 6.4 5 7.0 4.5 1.9 1 1 1 2 2 2 0 TMEM154 protein family SLC12 PF03522.15 CDI82962.1 - 4.2 6.3 15.7 5.4 5.9 15.7 1.2 1 0 0 1 1 1 0 Solute carrier family 12 FKS1_dom1 PF14288.6 CDI82962.1 - 4.4 7.7 10.6 0.28 11.5 4.2 1.9 1 1 1 2 2 2 0 1,3-beta-glucan synthase subunit FKS1, domain-1 Renin_r PF07850.14 CDI82962.1 - 4.6 7.9 6.8 5.2 7.7 3.2 2.2 2 0 0 2 2 2 0 Renin receptor-like protein GWT1 PF06423.12 CDI82962.1 - 5.2 7.2 8.2 2.4 8.3 2.2 2.1 1 1 1 2 2 2 0 GWT1 MPM1 PF17234.2 CDI82962.1 - 5.9 7.1 18.6 5.9 7.1 10.8 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 WASH-7_C PF14746.6 CDI82962.1 - 7.5 6.2 14.8 14 5.3 0.2 2.3 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal CSG2 PF16965.5 CDI82962.1 - 8.2 5.3 7.5 10 4.9 7.5 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Activator_LAG-3 PF11498.8 CDI82965.1 - 0.0064 15.5 3.6 0.0064 15.5 3.6 6.5 3 2 3 6 6 6 2 Transcriptional activator LAG-3 DUF2339 PF10101.9 CDI82965.1 - 0.094 11.3 26.9 0.49 8.9 21.4 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2339) RskA PF10099.9 CDI82975.1 - 0.0065 16.8 0.0 0.0065 16.8 0.0 10.4 2 2 1 6 6 6 1 Anti-sigma-K factor rskA Vps39_1 PF10366.9 CDI82975.1 - 0.78 10.0 7.7 3.2 8.1 7.7 2.1 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 SARAF PF06682.12 CDI82976.1 - 0.00011 21.9 20.1 0.00011 21.9 20.1 2.8 2 1 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis RskA PF10099.9 CDI82976.1 - 0.0032 17.8 5.6 0.0032 17.8 5.6 4.3 1 1 2 3 3 3 1 Anti-sigma-K factor rskA Utp14 PF04615.13 CDI82976.1 - 0.0048 15.6 20.0 0.012 14.2 15.6 2.1 2 0 0 2 2 2 2 Utp14 protein SPX PF03105.19 CDI82976.1 - 0.17 11.8 33.4 0.0067 16.4 8.2 2.3 1 1 1 2 2 2 0 SPX domain Hamartin PF04388.12 CDI82977.1 - 0.039 12.6 34.3 0.049 12.3 34.3 1.0 1 0 0 1 1 1 0 Hamartin protein BAF1_ABF1 PF04684.13 CDI82977.1 - 0.11 11.5 34.8 0.018 14.1 13.3 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor PBP1_TM PF14812.6 CDI82977.1 - 0.16 12.4 10.9 0.68 10.3 0.1 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Caldesmon PF02029.15 CDI82977.1 - 1.4 7.6 33.7 2.1 7.0 33.7 1.2 1 0 0 1 1 1 0 Caldesmon MDM10 PF12519.8 CDI82977.1 - 3.3 6.5 27.8 0.18 10.6 13.4 2.1 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 SR-25 PF10500.9 CDI82984.1 - 0.0045 16.6 10.7 0.006 16.2 10.7 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein PRAS PF15798.5 CDI82984.1 - 3.5 8.3 9.5 42 4.7 9.5 2.0 1 1 0 1 1 1 0 Proline-rich AKT1 substrate 1 Senescence_reg PF04520.13 CDI82984.1 - 5.2 7.9 11.6 6.3 7.6 11.6 1.2 1 0 0 1 1 1 0 Senescence regulator Sec62 PF03839.16 CDI82984.1 - 7.5 6.0 8.6 8.6 5.8 8.6 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Suf PF05843.14 CDI82986.1 - 0.0051 16.8 13.9 0.0062 16.6 13.9 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) HisKA_3 PF07730.13 CDI82986.1 - 0.0054 17.2 0.1 0.0054 17.2 0.1 2.7 1 1 2 3 3 2 1 Histidine kinase RHH_5 PF07878.11 CDI82986.1 - 0.034 14.0 0.1 0.034 14.0 0.1 2.1 2 0 0 2 2 2 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 Rox3 PF08633.10 CDI82986.1 - 0.044 14.1 11.6 0.053 13.8 11.6 1.0 1 0 0 1 1 1 0 Rox3 mediator complex subunit TFIIA PF03153.13 CDI82986.1 - 0.11 12.5 26.5 0.14 12.1 26.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI82986.1 - 0.18 10.6 12.0 0.2 10.4 12.0 1.1 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 CDI82986.1 - 0.21 9.5 13.7 0.26 9.2 13.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-ZPR1 PF03367.13 CDI82986.1 - 0.35 10.7 8.4 0.49 10.2 8.4 1.2 1 0 0 1 1 1 0 ZPR1 zinc-finger domain Herpes_UL25 PF01499.16 CDI82986.1 - 0.38 9.2 12.0 0.47 8.9 12.0 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family FAM60A PF15396.6 CDI82986.1 - 0.59 10.1 9.6 0.72 9.8 9.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Orf78 PF06024.12 CDI82986.1 - 0.74 10.2 7.6 0.088 13.1 1.9 1.9 2 0 0 2 2 2 0 Orf78 (ac78) Glt_symporter PF03616.14 CDI82986.1 - 0.75 8.4 2.3 1.3 7.7 2.3 1.3 1 0 0 1 1 1 0 Sodium/glutamate symporter DUF4569 PF15133.6 CDI82986.1 - 0.81 9.3 16.8 0.99 9.1 16.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Phage_GPO PF05929.11 CDI82986.1 - 0.9 9.1 17.1 1.2 8.7 17.1 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Neur_chan_memb PF02932.16 CDI82986.1 - 0.92 9.5 9.7 1 9.3 9.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GET2 PF08690.10 CDI82986.1 - 1.2 8.8 13.4 1.5 8.4 13.4 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 PigN PF04987.14 CDI82986.1 - 1.3 7.9 3.4 1.3 7.8 3.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) PAT1 PF09770.9 CDI82986.1 - 1.7 6.8 20.8 2 6.6 20.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hydin_ADK PF17213.3 CDI82986.1 - 1.7 8.9 10.6 2.1 8.6 10.6 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DcuA_DcuB PF03605.14 CDI82986.1 - 4.1 6.2 3.7 1.3 7.9 0.6 1.6 1 1 1 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter DDHD PF02862.17 CDI82986.1 - 4.1 7.5 12.9 5.6 7.0 12.9 1.2 1 0 0 1 1 1 0 DDHD domain Ndc1_Nup PF09531.10 CDI82986.1 - 4.3 5.9 10.9 5 5.7 10.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CAF1 PF04857.20 CDI82986.1 - 6 5.9 11.0 7.4 5.6 11.0 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease PDGF_N PF04692.13 CDI82986.1 - 8.3 7.3 13.4 0.69 10.7 7.8 1.9 1 1 1 2 2 2 0 Platelet-derived growth factor, N terminal region AAA_11 PF13086.6 CDI82986.1 - 9.4 5.9 16.1 12 5.6 16.1 1.1 1 0 0 1 1 1 0 AAA domain DUF5336 PF17270.2 CDI82986.1 - 9.9 5.8 10.6 17 5.0 10.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5336) Trp_oprn_chp PF09534.10 CDI82988.1 - 0.027 14.3 16.1 0.038 13.8 16.1 1.3 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) BAF1_ABF1 PF04684.13 CDI82988.1 - 0.22 10.5 25.2 0.24 10.4 25.2 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SARAF PF06682.12 CDI82988.1 - 0.58 9.7 18.0 0.81 9.3 18.0 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis ASD2 PF08687.11 CDI82988.1 - 1.1 8.7 25.0 1.3 8.6 25.0 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 CcmF_C PF16327.5 CDI82988.1 - 1.5 8.0 4.5 1.7 7.8 4.5 1.0 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal WRNPLPNID PF15017.6 CDI82988.1 - 2.5 9.0 18.2 0.5 11.3 2.4 2.1 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box FAM60A PF15396.6 CDI82988.1 - 3.1 7.8 20.2 3.7 7.5 20.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SfLAP PF11139.8 CDI82988.1 - 3.3 7.1 7.5 4.2 6.7 7.5 1.1 1 0 0 1 1 1 0 Sap, sulfolipid-1-addressing protein XRN_M PF17846.1 CDI82988.1 - 3.6 6.4 22.5 4.3 6.2 22.5 1.0 1 0 0 1 1 1 0 Xrn1 helical domain DUF3357 PF11837.8 CDI82988.1 - 3.8 8.0 12.5 5.5 7.5 12.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) SRRM_C PF15230.6 CDI82988.1 - 4.1 8.0 17.1 0.42 11.2 5.5 2.1 2 0 0 2 2 2 0 Serine/arginine repetitive matrix protein C-terminus SMYLE_N PF18615.1 CDI82988.1 - 4.1 6.8 19.1 5 6.6 19.1 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain CDC37_N PF03234.14 CDI82988.1 - 4.5 8.2 23.6 5.2 8.0 23.6 1.1 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding V_ATPase_I PF01496.19 CDI82988.1 - 4.5 5.1 20.9 6.8 4.5 20.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4569 PF15133.6 CDI82988.1 - 5.8 6.5 26.1 6.8 6.3 26.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) DUF4604 PF15377.6 CDI82988.1 - 6.5 7.1 27.5 7.8 6.9 27.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Serinc PF03348.15 CDI82988.1 - 7 5.5 15.3 9.8 5.0 15.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Presenilin PF01080.17 CDI82988.1 - 7.5 5.2 31.1 8.7 5.0 31.1 1.0 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 CDI82988.1 - 8.4 5.1 20.6 9.2 5.0 20.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter PPP4R2 PF09184.11 CDI82988.1 - 8.6 5.9 13.1 11 5.5 13.1 1.1 1 0 0 1 1 1 0 PPP4R2 HGTP_anticodon2 PF12745.7 CDI82991.1 - 0.0034 17.0 6.1 0.004 16.7 6.1 1.0 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs UPF0524 PF15823.5 CDI82991.1 - 0.012 15.0 3.4 0.012 15.1 3.4 1.2 1 0 0 1 1 1 0 UPF0524 of C3orf70 DUF3292 PF11696.8 CDI82991.1 - 0.018 13.4 5.0 0.019 13.3 5.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Spt20 PF12090.8 CDI82991.1 - 0.021 14.5 15.8 0.02 14.5 15.8 1.1 1 0 0 1 1 1 0 Spt20 family dsDNA_bind PF01984.20 CDI82991.1 - 0.027 14.7 12.2 0.036 14.3 12.2 1.1 1 0 0 1 1 1 0 Double-stranded DNA-binding domain Fer4_14 PF13394.6 CDI82991.1 - 0.045 13.9 0.0 0.046 13.9 0.0 1.2 1 0 0 1 1 1 0 4Fe-4S single cluster domain PsbQ PF05757.11 CDI82991.1 - 0.051 13.3 6.7 0.061 13.1 6.7 1.2 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) DUF3347 PF11827.8 CDI82991.1 - 0.085 13.0 7.5 0.093 12.9 7.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Pex14_N PF04695.13 CDI82991.1 - 0.43 11.2 13.1 0.49 11.0 12.5 1.5 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Roughex PF06020.11 CDI82991.1 - 0.7 8.9 6.6 0.69 8.9 6.6 1.1 1 0 0 1 1 1 0 Drosophila roughex protein E_Pc_C PF06752.12 CDI82991.1 - 0.97 9.5 24.9 1.4 9.0 24.9 1.3 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus Presenilin PF01080.17 CDI82991.1 - 1.5 7.5 5.8 1.4 7.6 5.8 1.1 1 0 0 1 1 1 0 Presenilin SelP_N PF04592.14 CDI82991.1 - 2 7.7 12.1 2.6 7.4 12.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Neur_chan_memb PF02932.16 CDI82991.1 - 2.8 7.9 5.8 3.1 7.8 5.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DivIC PF04977.15 CDI82991.1 - 5.6 6.8 10.3 9.4 6.1 10.3 1.3 1 0 0 1 1 1 0 Septum formation initiator Adeno_PV PF03910.13 CDI82993.1 - 0.037 12.7 0.5 0.056 12.2 0.5 1.2 1 0 0 1 1 1 0 Adenovirus minor core protein PV RskA PF10099.9 CDI83001.1 - 1.4 9.2 0.0 0.12 12.7 0.3 13.4 8 3 4 12 12 12 0 Anti-sigma-K factor rskA Connexin PF00029.19 CDI83001.1 - 4.5 7.0 8.9 3 7.5 0.1 3.8 3 0 0 3 3 3 0 Connexin MGC-24 PF05283.11 CDI83003.1 - 3.7 8.0 11.0 5.6 7.4 11.0 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin TMEM51 PF15345.6 CDI83014.1 - 0.00019 21.3 4.9 0.00021 21.2 4.9 1.0 1 0 0 1 1 1 1 Transmembrane protein 51 CobT PF06213.12 CDI83014.1 - 0.00022 20.7 11.1 0.00024 20.6 11.1 1.0 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT DUF4342 PF14242.6 CDI83014.1 - 0.0049 16.8 2.2 0.0081 16.1 2.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4342) FHIPEP PF00771.20 CDI83014.1 - 0.009 14.5 2.3 0.0098 14.4 2.3 1.0 1 0 0 1 1 1 1 FHIPEP family DUF2371 PF10177.9 CDI83014.1 - 0.01 16.0 0.1 0.013 15.6 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DUF5349 PF17298.2 CDI83014.1 - 0.014 15.2 6.0 0.015 15.1 6.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5349) DUF4179 PF13786.6 CDI83014.1 - 0.015 15.7 1.0 0.022 15.2 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) CPSF100_C PF13299.6 CDI83014.1 - 0.038 14.2 6.3 0.045 14.0 6.3 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal THOC2_N PF16134.5 CDI83014.1 - 0.061 11.9 6.8 0.073 11.7 6.8 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus DUF4834 PF16118.5 CDI83014.1 - 0.076 14.0 2.7 0.099 13.6 2.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Ureide_permease PF07168.11 CDI83014.1 - 0.091 11.5 1.5 0.1 11.3 1.5 1.0 1 0 0 1 1 1 0 Ureide permease 2HCT PF03390.15 CDI83014.1 - 0.12 11.0 2.5 0.14 10.7 2.5 1.0 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family R_equi_Vir PF05526.11 CDI83014.1 - 0.16 11.9 6.1 0.19 11.6 6.1 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein TFIIA PF03153.13 CDI83014.1 - 0.16 11.9 18.5 0.17 11.8 18.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Connexin PF00029.19 CDI83014.1 - 0.19 11.5 3.1 0.21 11.3 3.1 1.1 1 0 0 1 1 1 0 Connexin SID-1_RNA_chan PF13965.6 CDI83014.1 - 0.19 10.1 0.4 0.2 10.0 0.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI83014.1 - 0.21 10.5 2.1 0.23 10.4 2.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ctr PF04145.15 CDI83014.1 - 0.24 12.0 1.0 0.27 11.9 1.0 1.2 1 0 0 1 1 1 0 Ctr copper transporter family AIF_C PF14721.6 CDI83014.1 - 0.25 11.7 4.1 0.3 11.4 4.1 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term HA2 PF04408.23 CDI83014.1 - 0.41 11.0 4.3 0.56 10.5 4.3 1.2 1 0 0 1 1 1 0 Helicase associated domain (HA2) Neur_chan_memb PF02932.16 CDI83014.1 - 0.5 10.4 2.9 0.52 10.3 2.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RskA PF10099.9 CDI83014.1 - 0.55 10.5 18.7 1.3 9.3 18.7 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF4228 PF14009.6 CDI83014.1 - 0.91 9.9 7.5 1 9.7 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Spt20 PF12090.8 CDI83014.1 - 1.4 8.5 19.8 1.7 8.2 19.8 1.1 1 0 0 1 1 1 0 Spt20 family UPF0560 PF10577.9 CDI83014.1 - 1.8 6.9 11.2 1.9 6.9 11.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Presenilin PF01080.17 CDI83014.1 - 1.8 7.2 7.3 1.9 7.1 7.3 1.1 1 0 0 1 1 1 0 Presenilin DUF3676 PF12429.8 CDI83014.1 - 2 8.2 10.8 2.5 7.9 10.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3676) EphA2_TM PF14575.6 CDI83014.1 - 3.1 8.7 7.1 8 7.4 7.0 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF2722 PF10846.8 CDI83014.1 - 7.4 5.4 17.3 8.5 5.2 17.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF2681 PF10883.8 CDI83014.1 - 8.9 6.8 18.9 16 6.0 18.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) Med3 PF11593.8 CDI83022.1 - 7.4 5.6 16.6 9.1 5.3 16.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal RET_CLD4 PF17813.1 CDI83024.1 - 0.038 14.3 0.2 0.069 13.4 0.2 1.4 1 0 0 1 1 1 0 RET Cadherin like domain 4 SUIM_assoc PF16619.5 CDI83024.1 - 0.091 12.8 4.4 0.15 12.1 4.4 1.6 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI83024.1 - 2.6 7.6 8.4 3.7 7.1 8.4 1.2 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI83027.1 - 0.18 12.8 6.5 0.15 13.0 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 CDI83027.1 - 0.21 10.3 3.9 0.25 10.0 3.9 1.1 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 CDI83027.1 - 0.39 10.3 17.2 0.061 12.9 12.5 1.8 2 0 0 2 2 2 0 Spt20 family Sec16 PF12932.7 CDI83027.1 - 0.7 10.5 3.9 1.4 9.5 1.7 2.0 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region CDC45 PF02724.14 CDI83027.1 - 4.8 5.3 15.1 0.96 7.7 0.7 2.4 3 0 0 3 3 3 0 CDC45-like protein DUF1117 PF06547.12 CDI83027.1 - 5.4 7.6 7.5 4.1 8.0 3.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) Roughex PF06020.11 CDI83027.1 - 7.6 5.5 10.3 0.2 10.7 4.4 1.5 2 0 0 2 2 2 0 Drosophila roughex protein Sox_N PF12444.8 CDI83027.1 - 8.1 7.7 13.5 6.8 7.9 1.4 2.3 2 0 0 2 2 2 0 Sox developmental protein N terminal RPEL PF02755.15 CDI83030.1 - 0.048 13.4 2.2 8.8 6.2 0.2 2.7 2 0 0 2 2 2 0 RPEL repeat TFIIA PF03153.13 CDI83030.1 - 1.7 8.6 24.2 3.1 7.7 24.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI83034.1 - 1e-05 25.3 24.4 1e-05 25.3 24.4 5.1 4 1 0 4 4 4 2 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI83037.1 - 0.0033 18.1 4.2 0.0033 18.1 4.2 1.7 2 0 0 2 2 2 1 Immortalisation up-regulated protein SR-25 PF10500.9 CDI83037.1 - 0.006 16.2 26.4 0.011 15.4 26.4 1.5 1 1 0 1 1 1 1 Nuclear RNA-splicing-associated protein UNC-50 PF05216.13 CDI83037.1 - 0.012 15.1 0.1 0.019 14.5 0.1 1.3 1 0 0 1 1 1 0 UNC-50 family Chorion_2 PF03964.15 CDI83037.1 - 0.018 15.8 9.7 0.025 15.4 9.7 1.2 1 0 0 1 1 1 0 Chorion family 2 RskA PF10099.9 CDI83037.1 - 0.027 14.8 9.5 0.044 14.1 9.5 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Serinc PF03348.15 CDI83037.1 - 0.33 9.8 12.3 0.39 9.6 12.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Suf PF05843.14 CDI83037.1 - 0.9 9.5 31.3 1.3 8.9 31.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Nop53 PF07767.11 CDI83037.1 - 1.1 8.6 28.1 1.5 8.1 28.1 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Pol_alpha_B_N PF08418.10 CDI83037.1 - 1.4 8.8 22.4 1.7 8.6 22.4 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DUF572 PF04502.13 CDI83037.1 - 2.1 7.9 23.9 2.7 7.6 23.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) XRCC4 PF06632.12 CDI83037.1 - 2.2 7.1 26.9 3 6.6 26.9 1.2 1 1 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 SARAF PF06682.12 CDI83037.1 - 3.3 7.3 20.0 4.1 7.0 20.0 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis UCH PF00443.29 CDI83040.1 - 4.6e-13 49.3 0.0 5.8e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ORC2 PF04084.14 CDI83047.1 - 7.6e-32 110.5 0.0 3.2e-31 108.5 0.0 1.8 1 1 0 1 1 1 1 Origin recognition complex subunit 2 DUF755 PF05501.11 CDI83047.1 - 0.068 13.4 2.6 0.23 11.7 2.6 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF3619 PF12279.8 CDI83047.1 - 3.9 7.8 6.8 0.63 10.4 2.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) SCAB-PH PF17684.1 CDI83051.1 - 0.14 12.4 1.9 0.31 11.3 1.9 1.6 1 0 0 1 1 1 0 PH domain of plant-specific actin-binding protein SR-25 PF10500.9 CDI83051.1 - 0.98 9.0 17.7 3.9 7.0 17.7 1.8 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Miga PF10265.9 CDI83051.1 - 1.1 8.2 17.8 1.3 7.9 17.8 1.0 1 0 0 1 1 1 0 Mitoguardin SLY PF12485.8 CDI83051.1 - 5.1 7.8 12.5 0.43 11.3 5.3 2.1 2 0 0 2 2 2 0 Lymphocyte signaling adaptor protein AUX_IAA PF02309.16 CDI83051.1 - 5.3 6.8 17.6 11 5.8 17.6 1.6 1 1 0 1 1 1 0 AUX/IAA family RcpC PF16976.5 CDI83051.1 - 6.9 6.8 20.1 4.8 7.3 10.5 2.4 2 0 0 2 2 2 0 Flp pilus assembly protein RcpC/CpaB Activator_LAG-3 PF11498.8 CDI83052.1 - 0.0036 16.3 19.9 0.0036 16.3 19.9 3.0 2 1 0 2 2 1 1 Transcriptional activator LAG-3 EIF4E-T PF10477.9 CDI83052.1 - 0.0055 15.6 3.8 0.0055 15.6 3.8 3.0 2 1 1 3 3 2 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E PIP5K PF01504.18 CDI83052.1 - 0.039 13.2 15.3 0.12 11.6 6.4 2.3 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Saw1 PF11561.8 CDI83052.1 - 1.2 8.7 22.2 0.51 9.8 6.8 2.2 2 0 0 2 2 2 0 Single strand annealing-weakened 1 DUF1764 PF08576.10 CDI83052.1 - 2.1 9.3 22.1 9.8 7.1 8.8 3.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Connexin PF00029.19 CDI83052.1 - 2.6 7.7 20.9 4.9 6.8 4.4 2.3 2 0 0 2 2 2 0 Connexin GAGA_bind PF06217.12 CDI83052.1 - 3.7 7.8 23.8 8 6.6 13.8 2.4 2 0 0 2 2 2 0 GAGA binding protein-like family DUF2828 PF11443.8 CDI83052.1 - 4.5 5.2 23.8 2.8 5.9 3.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) DUF4776 PF16003.5 CDI83052.1 - 5.5 5.9 26.8 2.1 7.2 3.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) Peroxin-13_N PF04088.13 CDI83052.1 - 7 6.9 18.1 2.7 8.2 4.9 3.1 2 0 0 2 2 2 0 Peroxin 13, N-terminal region ALMT PF11744.8 CDI83052.1 - 7.1 5.3 27.0 2.4 6.9 15.0 2.4 2 0 0 2 2 2 0 Aluminium activated malate transporter PAT1 PF09770.9 CDI83052.1 - 7.5 4.7 51.9 0.41 8.9 8.8 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Velvet PF11754.8 CDI83060.1 - 0.0012 18.9 6.0 0.0019 18.2 6.0 1.3 1 0 0 1 1 1 1 Velvet factor Band_3_cyto PF07565.13 CDI83060.1 - 0.0034 17.2 7.0 0.0048 16.7 7.0 1.4 1 0 0 1 1 1 1 Band 3 cytoplasmic domain RskA PF10099.9 CDI83060.1 - 0.0088 16.3 11.0 0.0088 16.3 11.0 3.3 2 1 1 3 3 1 1 Anti-sigma-K factor rskA DUF5523 PF17661.1 CDI83060.1 - 0.032 13.9 17.7 0.052 13.2 17.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF3807 PF12720.7 CDI83060.1 - 0.035 14.4 22.0 0.058 13.7 22.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) LmjF365940-deam PF14421.6 CDI83060.1 - 0.045 13.3 1.0 0.061 12.9 1.0 1.4 1 0 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases Sin_N PF04801.13 CDI83060.1 - 0.052 12.8 24.3 0.062 12.5 24.3 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region SLC12 PF03522.15 CDI83060.1 - 0.14 11.1 16.1 0.16 10.9 16.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CCSAP PF15748.5 CDI83060.1 - 0.15 12.2 18.2 0.21 11.8 18.2 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Lin-8 PF03353.15 CDI83060.1 - 0.19 11.3 16.7 0.24 10.9 16.7 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2052 PF09747.9 CDI83060.1 - 0.21 11.7 20.5 0.29 11.2 20.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PAT1 PF09770.9 CDI83060.1 - 0.23 9.7 25.6 0.28 9.4 25.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CAC1F_C PF16885.5 CDI83060.1 - 0.25 11.0 13.6 0.34 10.5 13.6 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Hid1 PF12722.7 CDI83060.1 - 0.28 9.2 14.5 0.39 8.8 14.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Connexin PF00029.19 CDI83060.1 - 0.35 10.6 15.4 0.61 9.8 12.2 2.2 2 0 0 2 2 2 0 Connexin ALMT PF11744.8 CDI83060.1 - 0.44 9.3 13.0 0.54 9.0 13.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PIP5K PF01504.18 CDI83060.1 - 0.6 9.3 12.6 0.79 8.9 12.6 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Peptidase_S64 PF08192.11 CDI83060.1 - 0.62 8.5 11.9 0.74 8.2 11.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 Orf78 PF06024.12 CDI83060.1 - 0.62 10.4 0.0 0.62 10.4 0.0 3.2 2 1 1 3 3 3 0 Orf78 (ac78) Neur_chan_memb PF02932.16 CDI83060.1 - 0.68 9.9 14.2 1.1 9.3 14.2 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Mid2 PF04478.12 CDI83060.1 - 0.7 9.7 0.0 0.7 9.7 0.0 2.7 2 1 1 3 3 2 0 Mid2 like cell wall stress sensor Gti1_Pac2 PF09729.9 CDI83060.1 - 0.72 9.9 14.0 1.1 9.3 14.0 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family TMEM154 PF15102.6 CDI83060.1 - 0.74 9.7 0.0 0.74 9.7 0.0 3.0 2 1 0 2 2 1 0 TMEM154 protein family SpoIIP PF07454.11 CDI83060.1 - 0.76 9.2 18.9 1.4 8.4 18.9 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Plasmodium_Vir PF05795.11 CDI83060.1 - 0.84 9.0 6.5 0.94 8.8 6.5 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF1764 PF08576.10 CDI83060.1 - 1.2 10.1 18.4 2.4 9.1 18.4 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) XRN_M PF17846.1 CDI83060.1 - 1.2 8.0 12.5 1.6 7.6 12.5 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Auxin_canalis PF05703.11 CDI83060.1 - 1.2 9.0 21.6 2.1 8.2 21.6 1.3 1 0 0 1 1 1 0 Auxin canalisation NPR3 PF03666.13 CDI83060.1 - 1.4 7.7 18.1 1.8 7.3 18.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FGF-BP1 PF06473.12 CDI83060.1 - 1.4 8.7 26.3 0.62 9.9 21.2 2.1 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) RR_TM4-6 PF06459.12 CDI83060.1 - 1.5 8.6 23.4 2.1 8.1 23.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4050 PF13259.6 CDI83060.1 - 1.6 9.1 19.3 3 8.1 19.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) CDC45 PF02724.14 CDI83060.1 - 2.2 6.5 19.5 0.17 10.1 14.9 1.4 2 0 0 2 2 2 0 CDC45-like protein PPL5 PF18168.1 CDI83060.1 - 3.7 6.7 14.0 6.4 6.0 14.0 1.3 1 0 0 1 1 1 0 Prim-pol family 5 DUF4638 PF15472.6 CDI83060.1 - 4.1 7.1 17.9 5.7 6.6 17.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) RPN2_C PF18004.1 CDI83060.1 - 4.5 7.2 20.4 8 6.4 20.4 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF913 PF06025.12 CDI83060.1 - 4.9 6.0 13.1 7.2 5.5 13.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CRT10 PF08728.10 CDI83060.1 - 5.1 5.1 9.9 5.6 5.0 9.9 1.0 1 0 0 1 1 1 0 CRT10 DUF2126 PF09899.9 CDI83060.1 - 5.2 5.0 11.9 6.4 4.7 11.9 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) FAM60A PF15396.6 CDI83060.1 - 5.2 7.0 14.1 7.5 6.5 14.1 1.2 1 0 0 1 1 1 0 Protein Family FAM60A HCO3_cotransp PF00955.21 CDI83060.1 - 5.8 5.6 6.2 8.9 5.0 6.2 1.3 1 0 0 1 1 1 0 HCO3- transporter family CCDC53 PF10152.9 CDI83060.1 - 5.8 7.3 23.4 3.3 8.1 20.0 2.1 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Rrn6 PF10214.9 CDI83060.1 - 6.2 5.2 23.1 7.4 4.9 23.1 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor GAGA_bind PF06217.12 CDI83060.1 - 6.3 7.0 17.5 9.2 6.4 17.5 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DUF2828 PF11443.8 CDI83060.1 - 6.7 4.7 20.0 8.3 4.4 20.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) GREB1 PF15782.5 CDI83060.1 - 7.5 3.5 15.5 8.1 3.4 15.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Tim54 PF11711.8 CDI83060.1 - 7.6 5.2 17.1 12 4.6 17.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Baculo_PP31 PF05311.11 CDI83060.1 - 7.6 5.9 20.1 11 5.3 20.1 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF2370 PF10176.9 CDI83060.1 - 7.9 6.1 11.3 13 5.3 11.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) TRAP_alpha PF03896.16 CDI83060.1 - 8.4 5.5 14.0 3.7 6.7 8.4 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit XRN_N PF03159.18 CDI83061.1 - 1.7e-35 122.6 2.0 1.7e-35 122.6 2.0 4.5 1 1 2 4 4 4 2 XRN 5'-3' exonuclease N-terminus eIF-3_zeta PF05091.12 CDI83061.1 - 0.0021 17.1 13.9 0.0021 17.1 13.9 3.9 3 1 1 4 4 4 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Mucin PF01456.17 CDI83061.1 - 0.0071 16.3 1.0 0.0071 16.3 1.0 4.2 4 2 2 6 6 6 1 Mucin-like glycoprotein SUIM_assoc PF16619.5 CDI83061.1 - 0.0084 16.2 4.8 0.0084 16.2 4.8 8.5 5 3 0 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 Shadoo PF14999.6 CDI83061.1 - 0.034 14.2 21.8 0.42 10.7 0.9 3.4 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective Ribosomal_60s PF00428.19 CDI83061.1 - 2 9.0 54.3 0.86 10.2 14.7 4.2 4 0 0 4 4 4 0 60s Acidic ribosomal protein Peroxin-13_N PF04088.13 CDI83063.1 - 0.0063 16.8 0.2 0.0072 16.6 0.2 1.1 1 0 0 1 1 1 1 Peroxin 13, N-terminal region RPN1_RPN2_N PF17781.1 CDI83063.1 - 0.055 12.9 2.5 0.067 12.6 2.5 1.0 1 0 0 1 1 1 0 RPN1/RPN2 N-terminal domain PEX11 PF05648.14 CDI83063.1 - 0.075 12.5 0.4 0.073 12.5 0.4 1.0 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Spt20 PF12090.8 CDI83063.1 - 0.084 12.5 18.2 0.085 12.5 18.2 1.1 1 0 0 1 1 1 0 Spt20 family Suf PF05843.14 CDI83063.1 - 0.1 12.5 6.8 0.1 12.5 6.8 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF5336 PF17270.2 CDI83063.1 - 0.11 12.2 5.3 0.11 12.1 5.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5336) DUF2722 PF10846.8 CDI83063.1 - 0.15 11.0 14.5 0.14 11.1 14.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI83063.1 - 0.15 12.0 15.1 0.14 12.1 15.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DivIC PF04977.15 CDI83063.1 - 0.21 11.4 5.9 0.25 11.2 5.9 1.1 1 0 0 1 1 1 0 Septum formation initiator FPN1 PF06963.12 CDI83063.1 - 0.26 9.8 1.1 0.28 9.7 1.1 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) DUF4834 PF16118.5 CDI83063.1 - 0.37 11.8 5.3 0.41 11.6 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Androgen_recep PF02166.16 CDI83063.1 - 1.6 7.4 17.6 1.7 7.4 17.6 1.2 1 0 0 1 1 1 0 Androgen receptor Activator_LAG-3 PF11498.8 CDI83063.1 - 3.5 6.5 24.3 3.6 6.5 24.3 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 CDC13_N PF16853.5 CDI83063.1 - 8.5 5.8 10.0 11 5.5 10.0 1.1 1 0 0 1 1 1 0 Cell division control protein 13 N-terminus Roughex PF06020.11 CDI83063.1 - 9.3 5.2 8.0 9.2 5.2 8.0 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Macoilin PF09726.9 CDI83089.1 - 6 5.3 5.7 9.3 4.7 5.7 1.3 1 0 0 1 1 1 0 Macoilin family MMR_HSR1 PF01926.23 CDI83091.1 - 3.3e-14 53.0 0.0 6.5e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDI83091.1 - 0.00018 21.5 0.0 0.065 13.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 CDI83091.1 - 0.0012 18.4 0.0 0.0019 17.7 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CDI83091.1 - 0.019 15.1 0.0 0.13 12.3 0.1 2.3 2 0 0 2 2 2 0 Dynamin family GTP_EFTU PF00009.27 CDI83091.1 - 0.036 13.6 0.0 7.3 6.1 0.0 2.6 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Hexose_dehydrat PF03559.14 CDI83092.1 - 0.079 12.4 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase Spt20 PF12090.8 CDI83096.1 - 0.00017 21.3 16.9 0.00017 21.3 16.9 1.1 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI83096.1 - 0.00024 20.2 12.6 0.00024 20.2 12.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI83096.1 - 0.0058 16.7 19.2 0.0063 16.6 19.2 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CDK2AP PF09806.9 CDI83096.1 - 0.031 14.3 10.6 0.037 14.1 10.6 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DUF4159 PF13709.6 CDI83096.1 - 0.038 13.4 0.9 0.047 13.1 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4159) Pribosyltran PF00156.27 CDI83096.1 - 0.046 13.2 0.1 0.046 13.2 0.1 1.5 2 0 0 2 2 2 0 Phosphoribosyl transferase domain EPL1 PF10513.9 CDI83096.1 - 0.076 13.4 7.3 0.086 13.2 7.3 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF3347 PF11827.8 CDI83096.1 - 0.13 12.4 9.5 0.17 12.1 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Gti1_Pac2 PF09729.9 CDI83096.1 - 0.16 12.0 3.9 0.19 11.8 3.9 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Robl_LC7 PF03259.17 CDI83096.1 - 0.17 11.7 3.1 0.27 11.0 3.1 1.4 1 0 0 1 1 1 0 Roadblock/LC7 domain Med15 PF09606.10 CDI83096.1 - 0.18 10.5 17.6 0.18 10.4 17.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TERB2 PF15101.6 CDI83096.1 - 0.18 11.8 8.3 0.18 11.8 8.3 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF2367 PF10164.9 CDI83096.1 - 0.22 12.0 2.1 0.26 11.8 2.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) Peptidase_S49_N PF08496.10 CDI83096.1 - 0.24 11.4 6.1 0.28 11.2 6.1 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3138 PF11336.8 CDI83096.1 - 0.29 9.7 15.6 0.31 9.6 15.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) BAT2_N PF07001.11 CDI83096.1 - 0.32 11.4 11.7 0.38 11.2 11.7 1.1 1 0 0 1 1 1 0 BAT2 N-terminus Connexin PF00029.19 CDI83096.1 - 0.38 10.5 2.1 0.39 10.4 2.1 1.2 1 0 0 1 1 1 0 Connexin BAF1_ABF1 PF04684.13 CDI83096.1 - 0.45 9.5 10.4 0.5 9.4 10.4 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4824 PF16106.5 CDI83096.1 - 0.58 9.4 11.7 0.56 9.4 10.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4824) Ndc1_Nup PF09531.10 CDI83096.1 - 0.62 8.7 8.1 0.71 8.5 8.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Suf PF05843.14 CDI83096.1 - 0.67 9.9 8.9 0.68 9.9 8.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2828 PF11443.8 CDI83096.1 - 0.76 7.8 8.6 0.8 7.7 8.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CLN3 PF02487.17 CDI83096.1 - 1 8.3 4.7 1.1 8.3 4.7 1.1 1 0 0 1 1 1 0 CLN3 protein Presenilin PF01080.17 CDI83096.1 - 1.2 7.8 9.0 1.3 7.7 9.0 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI83096.1 - 1.3 9.0 4.3 1.3 9.0 4.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region UPF0560 PF10577.9 CDI83096.1 - 1.5 7.2 11.6 1.5 7.2 11.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Sec62 PF03839.16 CDI83096.1 - 1.7 8.1 5.6 1.9 7.9 5.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 RR_TM4-6 PF06459.12 CDI83096.1 - 2.2 8.0 8.9 2.5 7.8 8.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DivIC PF04977.15 CDI83096.1 - 2.3 8.0 13.5 3.6 7.4 13.5 1.4 1 0 0 1 1 1 0 Septum formation initiator ALMT PF11744.8 CDI83096.1 - 3.1 6.5 6.3 3.3 6.4 6.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Roughex PF06020.11 CDI83096.1 - 7 5.6 13.3 8.6 5.3 13.3 1.1 1 0 0 1 1 1 0 Drosophila roughex protein TFIIF_beta_N PF17683.1 CDI83096.1 - 7.4 7.3 11.8 12 6.6 11.8 1.6 1 1 0 1 1 1 0 TFIIF, beta subunit N-terminus RskA PF10099.9 CDI83103.1 - 0.0028 18.0 20.5 0.0028 18.0 20.5 2.8 1 1 1 2 2 2 1 Anti-sigma-K factor rskA DUF3402 PF11882.8 CDI83103.1 - 0.023 13.8 4.4 0.033 13.3 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) CDV3 PF15359.6 CDI83103.1 - 0.23 12.0 15.0 0.74 10.3 10.9 2.6 2 1 1 3 3 3 0 Carnitine deficiency-associated protein 3 Serinc PF03348.15 CDI83103.1 - 0.37 9.6 2.2 0.58 9.0 2.2 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Sin_N PF04801.13 CDI83103.1 - 1.9 7.6 22.6 0.37 9.9 18.8 1.6 2 0 0 2 2 2 0 Sin-like protein conserved region Sec62 PF03839.16 CDI83103.1 - 2.7 7.4 5.5 4.3 6.8 5.5 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 CPSF100_C PF13299.6 CDI83103.1 - 7.6 6.7 12.0 3.7 7.7 5.0 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 CDI83103.1 - 9.3 4.9 13.8 2.8 6.6 10.2 1.7 2 0 0 2 2 2 0 Presenilin Porph_ging PF09697.10 CDI83114.1 - 0.039 14.5 1.9 0.039 14.5 1.9 3.3 1 1 1 2 2 2 0 Protein of unknown function (Porph_ging) DUF599 PF04654.12 CDI83114.1 - 2.9 7.2 7.4 3 7.2 6.6 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF599 BAF1_ABF1 PF04684.13 CDI83114.1 - 5 6.1 50.5 6.1 5.8 50.5 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SR-25 PF10500.9 CDI83114.1 - 9.2 5.8 58.3 9.6 5.7 23.1 2.3 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI83116.1 - 0.00079 19.8 0.1 0.0026 18.1 0.1 1.8 1 1 0 1 1 1 1 Anti-sigma-K factor rskA PIEZO PF15917.5 CDI83116.1 - 0.0051 16.3 12.0 0.0065 16.0 12.0 1.2 1 0 0 1 1 1 1 Piezo TFIIA PF03153.13 CDI83116.1 - 0.013 15.5 22.2 0.015 15.3 22.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4123 PF13503.6 CDI83116.1 - 0.033 14.6 7.2 0.16 12.4 4.2 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4123) ALS2CR11 PF15729.5 CDI83116.1 - 0.038 13.1 7.9 0.048 12.8 7.9 1.1 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 Muted PF14942.6 CDI83116.1 - 0.049 14.0 11.7 0.086 13.2 11.7 1.4 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Indigoidine_A PF04227.12 CDI83116.1 - 0.15 11.4 1.1 0.23 10.8 1.1 1.2 1 0 0 1 1 1 0 Indigoidine synthase A like protein V_ATPase_I PF01496.19 CDI83116.1 - 0.33 8.8 8.2 0.35 8.7 8.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ALMT PF11744.8 CDI83116.1 - 0.84 8.4 7.8 0.99 8.2 7.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter AAA_23 PF13476.6 CDI83116.1 - 1.1 9.7 14.8 2.1 8.8 14.8 1.5 1 0 0 1 1 1 0 AAA domain DUF5421 PF17458.2 CDI83116.1 - 1.6 8.0 9.4 2.1 7.6 9.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5421) DUF3464 PF11947.8 CDI83116.1 - 2 8.1 8.8 6.4 6.5 8.8 1.9 1 1 0 1 1 1 0 Photosynthesis affected mutant 68 Presenilin PF01080.17 CDI83116.1 - 2.2 7.0 5.4 2.2 7.0 5.4 1.2 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI83116.1 - 3.4 7.7 6.1 3.7 7.5 6.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LMBR1 PF04791.16 CDI83116.1 - 3.7 6.3 6.2 4.2 6.2 6.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein FTCD_C PF04961.12 CDI83116.1 - 4.6 7.0 10.5 0.03 14.1 1.9 1.7 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase FapA PF03961.13 CDI83116.1 - 4.9 5.6 8.6 6.6 5.2 8.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Hydin_ADK PF17213.3 CDI83116.1 - 6.3 7.0 8.9 11 6.3 8.9 1.5 1 1 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF1635 PF07795.11 CDI83129.1 - 0.0029 17.5 6.3 0.0032 17.4 6.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1635) TraT PF05818.12 CDI83129.1 - 0.0095 15.6 4.8 0.011 15.4 4.8 1.1 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein AF-4 PF05110.13 CDI83129.1 - 0.046 11.8 15.9 0.048 11.8 15.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CD20 PF04103.15 CDI83129.1 - 0.078 13.1 0.8 0.098 12.7 0.8 1.1 1 0 0 1 1 1 0 CD20-like family SR-25 PF10500.9 CDI83129.1 - 0.083 12.5 25.4 0.094 12.3 25.4 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Secretin_N_2 PF07655.13 CDI83129.1 - 0.094 13.3 15.6 0.13 12.8 15.6 1.2 1 0 0 1 1 1 0 Secretin N-terminal domain DUF4692 PF15763.5 CDI83129.1 - 0.11 13.0 10.9 0.12 12.9 10.9 1.1 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) IQCJ-SCHIP1 PF15157.6 CDI83129.1 - 0.13 12.1 4.3 0.14 12.0 4.3 1.1 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif CCDC106 PF15794.5 CDI83129.1 - 0.28 10.9 8.7 0.33 10.6 8.7 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Ctr PF04145.15 CDI83129.1 - 0.55 10.8 3.2 0.65 10.6 3.2 1.1 1 0 0 1 1 1 0 Ctr copper transporter family DUF3947 PF13135.6 CDI83129.1 - 0.59 10.4 5.4 0.93 9.7 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) Mcm10 PF09332.11 CDI83129.1 - 0.61 9.5 11.5 0.63 9.4 11.5 1.0 1 0 0 1 1 1 0 Mcm10 replication factor PA26 PF04636.13 CDI83129.1 - 0.62 8.9 5.9 0.65 8.9 5.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) TAF4 PF05236.14 CDI83129.1 - 0.65 9.7 13.9 0.69 9.6 13.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Menin PF05053.13 CDI83129.1 - 0.67 8.2 14.0 0.69 8.2 14.0 1.0 1 0 0 1 1 1 0 Menin SecG PF03840.14 CDI83129.1 - 1 9.5 5.0 1.9 8.6 1.9 2.1 2 0 0 2 2 2 0 Preprotein translocase SecG subunit DUF4400 PF14348.6 CDI83129.1 - 1.1 8.8 8.7 1.1 8.7 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) LPP20 PF02169.16 CDI83129.1 - 1.3 9.5 14.4 1.7 9.0 14.4 1.2 1 0 0 1 1 1 0 LPP20 lipoprotein SARAF PF06682.12 CDI83129.1 - 1.7 8.2 11.6 2.1 7.9 11.6 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Apt1 PF10351.9 CDI83129.1 - 2.5 6.8 11.4 2.5 6.9 11.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain BAF1_ABF1 PF04684.13 CDI83129.1 - 2.7 6.9 12.1 3 6.8 12.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4228 PF14009.6 CDI83129.1 - 3.2 8.1 11.0 3.5 8.0 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Spt20 PF12090.8 CDI83129.1 - 3.8 7.1 12.1 4.1 6.9 12.1 1.1 1 0 0 1 1 1 0 Spt20 family Lin-8 PF03353.15 CDI83129.1 - 5.6 6.4 9.4 6.1 6.3 9.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 CDI83129.1 - 8.5 5.0 10.9 8.8 5.0 10.9 1.0 1 0 0 1 1 1 0 Presenilin RAP1 PF07218.11 CDI83129.1 - 8.9 4.4 17.4 9.8 4.3 17.4 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) EBP50_C PF09007.11 CDI83129.1 - 9 7.3 15.3 12 6.9 15.3 1.3 1 1 0 1 1 1 0 EBP50, C-terminal Pkinase PF00069.25 CDI83131.1 - 4.8e-49 167.1 0.0 5.2e-48 163.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83131.1 - 4.8e-34 117.8 0.0 6.9e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI83131.1 - 2.6e-07 30.3 0.0 4.3e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDI83131.1 - 3.2e-06 26.2 0.0 5.4e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase RRM_1 PF00076.22 CDI83132.1 - 1.1e-29 102.0 0.0 1e-17 63.7 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI83132.1 - 1.7e-06 28.1 0.1 1.7e-05 24.8 0.1 2.5 2 2 0 2 2 2 1 RNA recognition motif DUF3137 PF11335.8 CDI83133.1 - 0.047 13.6 2.8 0.13 12.2 1.7 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3137) Toprim PF01751.22 CDI83133.1 - 0.63 10.3 0.0 0.63 10.3 0.0 3.7 4 2 0 4 4 4 0 Toprim domain RPW8 PF05659.11 CDI83134.1 - 0.11 12.2 18.4 1.1 9.0 0.7 4.1 1 1 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 NPV_P10 PF05531.12 CDI83134.1 - 0.15 12.5 6.7 6.2 7.4 0.6 3.5 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Bacillus_HBL PF05791.11 CDI83134.1 - 0.4 10.5 14.3 0.11 12.4 5.1 3.3 2 2 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) SIR2 PF02146.17 CDI83134.1 - 0.41 10.6 3.9 0.24 11.3 1.7 1.7 2 0 0 2 2 2 0 Sir2 family DUF948 PF06103.11 CDI83134.1 - 0.45 10.8 8.9 1.9 8.8 0.9 4.0 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Fez1 PF06818.15 CDI83134.1 - 1.1 9.7 34.3 0.26 11.7 9.7 2.6 2 1 0 2 2 2 0 Fez1 HisKA_3 PF07730.13 CDI83134.1 - 3.4 8.3 10.6 16 6.1 0.2 4.2 3 1 1 4 4 4 0 Histidine kinase DUF2730 PF10805.8 CDI83134.1 - 4.3 7.5 18.4 0.071 13.2 2.7 4.0 2 2 2 4 4 4 0 Protein of unknown function (DUF2730) DUF883 PF05957.13 CDI83137.1 - 2.2 8.9 8.8 53 4.5 6.8 2.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Exonuc_VII_L PF02601.15 CDI83137.1 - 3.4 7.1 12.3 5.6 6.5 12.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit RRM_1 PF00076.22 CDI83138.1 - 2.1e-33 114.0 0.1 1.2e-15 57.1 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI83138.1 - 1.8e-06 28.0 0.1 0.037 14.2 0.0 3.0 2 2 0 2 2 2 2 RNA recognition motif OB_RNB PF08206.11 CDI83138.1 - 0.035 13.8 0.1 0.52 10.0 0.0 2.3 2 0 0 2 2 2 0 Ribonuclease B OB domain Adeno_PV PF03910.13 CDI83138.1 - 2.3 6.9 9.7 3.7 6.1 9.7 1.3 1 0 0 1 1 1 0 Adenovirus minor core protein PV Activator_LAG-3 PF11498.8 CDI83140.1 - 0.026 13.5 48.9 0.027 13.4 48.9 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 AAA_23 PF13476.6 CDI83140.1 - 0.099 13.1 17.3 0.12 12.8 17.3 1.1 1 0 0 1 1 1 0 AAA domain TFIIF_beta_N PF17683.1 CDI83140.1 - 0.12 13.0 13.8 0.15 12.7 13.8 1.2 1 0 0 1 1 1 0 TFIIF, beta subunit N-terminus DUF1682 PF07946.14 CDI83140.1 - 0.12 11.5 8.4 0.13 11.4 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) eIF-3_zeta PF05091.12 CDI83140.1 - 0.97 8.3 15.6 0.95 8.4 15.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI83140.1 - 5.9 5.5 16.1 6 5.5 16.1 1.0 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI83140.1 - 6 6.8 41.9 6.3 6.7 41.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI83140.1 - 6.1 6.8 9.3 6.3 6.8 9.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CEP44 PF15007.6 CDI83153.1 - 1e-43 148.5 0.0 3.1e-43 147.0 0.0 1.8 2 0 0 2 2 2 1 Centrosomal spindle body, CEP44 Gal4_dimer PF03902.13 CDI83153.1 - 0.095 12.9 0.2 0.26 11.5 0.2 1.8 1 0 0 1 1 1 0 Gal4-like dimerisation domain SR-25 PF10500.9 CDI83154.1 - 0.0017 18.0 4.8 0.0017 18.0 4.8 8.4 5 2 2 8 8 8 5 Nuclear RNA-splicing-associated protein TPPK_C PF12555.8 CDI83157.1 - 0.17 11.9 1.3 0.84 9.7 0.7 2.1 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal 1-cysPrx_C PF10417.9 CDI83158.1 - 2.8e-12 46.3 0.0 4.8e-12 45.5 0.0 1.4 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin PapC_N PF13954.6 CDI83158.1 - 0.12 12.4 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 PapC N-terminal domain AP2 PF00847.20 CDI83161.1 - 0.0087 16.3 0.2 0.0087 16.3 0.2 4.0 6 0 0 6 6 2 1 AP2 domain Lin-8 PF03353.15 CDI83161.1 - 0.01 15.4 11.9 0.012 15.1 11.9 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Sin_N PF04801.13 CDI83161.1 - 0.13 11.4 19.7 0.18 10.9 19.7 1.4 1 0 0 1 1 1 0 Sin-like protein conserved region PA26 PF04636.13 CDI83161.1 - 0.23 10.4 12.2 0.32 9.9 12.2 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Tho2 PF11262.8 CDI83161.1 - 0.4 9.8 9.4 0.54 9.4 9.4 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Tim54 PF11711.8 CDI83161.1 - 0.44 9.3 11.5 0.78 8.5 11.5 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Band_3_cyto PF07565.13 CDI83161.1 - 0.85 9.4 13.0 1.4 8.6 13.0 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SOBP PF15279.6 CDI83161.1 - 0.85 10.2 20.8 1.2 9.7 20.8 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein NPR3 PF03666.13 CDI83161.1 - 0.95 8.2 14.9 1.4 7.6 14.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Hid1 PF12722.7 CDI83161.1 - 1.2 7.1 15.7 1.3 7.1 15.7 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Utp14 PF04615.13 CDI83161.1 - 1.6 7.2 30.6 2.2 6.8 30.6 1.2 1 0 0 1 1 1 0 Utp14 protein Peptidase_S64 PF08192.11 CDI83161.1 - 1.8 7.0 11.6 1.9 6.9 11.6 1.2 1 0 0 1 1 1 0 Peptidase family S64 MAJIN PF15077.6 CDI83161.1 - 2.1 8.0 11.4 3.2 7.5 11.4 1.5 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF4100 PF13352.6 CDI83161.1 - 2.2 8.0 13.0 0.78 9.5 10.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4100) Otopetrin PF03189.13 CDI83161.1 - 2.9 6.6 4.3 3.5 6.3 4.3 1.3 1 0 0 1 1 1 0 Otopetrin FAM60A PF15396.6 CDI83161.1 - 3 7.8 11.9 5.7 6.9 11.9 1.6 1 0 0 1 1 1 0 Protein Family FAM60A XRN_M PF17846.1 CDI83161.1 - 3.2 6.6 14.9 5.4 5.9 14.9 1.5 1 0 0 1 1 1 0 Xrn1 helical domain ALMT PF11744.8 CDI83161.1 - 3.4 6.4 14.7 5.1 5.8 14.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter eIF-3_zeta PF05091.12 CDI83161.1 - 3.7 6.4 20.2 5.9 5.8 20.2 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SLC12 PF03522.15 CDI83161.1 - 5.5 5.9 18.0 7.3 5.5 18.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4638 PF15472.6 CDI83161.1 - 7.9 6.1 13.4 14 5.3 13.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Apt1 PF10351.9 CDI83171.1 - 0.0031 16.5 15.2 0.0031 16.5 15.2 4.4 5 1 1 6 6 6 1 Golgi-body localisation protein domain RNA_pol_Rpb4 PF03874.16 CDI83179.1 - 0.00011 22.5 0.0 0.00036 20.8 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb4 Presenilin PF01080.17 CDI83179.1 - 5.4 5.7 5.5 6.7 5.4 5.5 1.1 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 CDI83180.1 - 0.016 16.1 3.0 1.1e+02 4.0 0.0 5.4 5 0 0 5 5 5 0 WD domain, G-beta repeat DUF2205 PF10224.9 CDI83181.1 - 0.0068 16.4 6.4 0.0096 15.9 1.1 2.6 2 0 0 2 2 2 1 Short coiled-coil protein SlyX PF04102.12 CDI83181.1 - 0.011 16.4 8.3 2.7 8.7 0.0 4.6 4 1 1 5 5 5 0 SlyX Keratin_matx PF04579.12 CDI83181.1 - 0.075 13.4 1.8 0.4 11.0 0.0 2.5 2 0 0 2 2 2 0 Keratin, high-sulphur matrix protein DUF4407 PF14362.6 CDI83181.1 - 0.091 12.1 2.7 0.092 12.1 0.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Lebercilin PF15619.6 CDI83181.1 - 1.8 8.2 15.2 1.8 8.2 0.7 3.5 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF4349 PF14257.6 CDI83181.1 - 4.3 6.7 8.4 1 8.8 1.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) KxDL PF10241.9 CDI83181.1 - 4.7 7.6 9.9 6.8 7.0 1.9 2.8 2 0 0 2 2 2 0 Uncharacterized conserved protein Metallophos PF00149.28 CDI83182.1 - 1.2e-08 35.7 0.0 1.7e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDI83182.1 - 0.0028 17.9 0.0 0.0037 17.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Mre11_DNA_bind PF04152.14 CDI83183.1 - 1.6e-31 109.9 0.1 1e-21 78.0 0.0 3.1 2 1 2 4 4 4 2 Mre11 DNA-binding presumed domain Na_K-ATPase PF00287.18 CDI83183.1 - 0.04 13.1 1.2 0.082 12.1 1.2 1.4 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain SPATA3 PF15662.5 CDI83183.1 - 1.7 9.2 12.0 7.2 7.2 0.1 2.3 2 0 0 2 2 2 0 Spermatogenesis-associated protein 3 family DUF1180 PF06679.12 CDI83183.1 - 2 8.8 4.5 3.2 8.1 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) RR_TM4-6 PF06459.12 CDI83183.1 - 3.6 7.3 7.9 5.9 6.6 7.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spt20 PF12090.8 CDI83183.1 - 3.9 7.0 17.6 6.5 6.3 17.6 1.3 1 0 0 1 1 1 0 Spt20 family RPN2_C PF18004.1 CDI83184.1 - 0.015 15.2 2.8 0.015 15.2 2.8 4.8 3 1 1 4 4 4 0 26S proteasome regulatory subunit RPN2 C-terminal domain TFIIA PF03153.13 CDI83185.1 - 0.93 9.4 38.6 1.1 9.2 38.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PA26 PF04636.13 CDI83185.1 - 1.3 7.9 14.6 1.7 7.4 14.6 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PPP4R2 PF09184.11 CDI83185.1 - 4.7 6.7 26.1 6.1 6.3 26.1 1.2 1 0 0 1 1 1 0 PPP4R2 MAP7 PF05672.11 CDI83187.1 - 0.097 12.4 57.0 0.11 12.1 57.0 1.1 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family CCSAP PF15748.5 CDI83187.1 - 3.8 7.6 48.2 4.7 7.3 48.2 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Dsh_C PF12316.8 CDI83187.1 - 7 7.0 32.6 8.6 6.7 32.6 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal FYDLN_acid PF09538.10 CDI83191.1 - 4.9 7.9 16.2 7.1 7.4 16.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) CobT PF06213.12 CDI83191.1 - 6.5 6.1 37.8 7.1 5.9 37.8 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SUIM_assoc PF16619.5 CDI83200.1 - 0.32 11.1 13.3 1.1 9.4 11.3 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF737 PF05300.11 CDI83200.1 - 0.4 11.0 13.6 0.029 14.7 3.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF737) Condensation PF00668.20 CDI83200.1 - 0.78 8.3 5.4 1.2 7.7 5.4 1.1 1 0 0 1 1 1 0 Condensation domain TFIIA PF03153.13 CDI83206.1 - 0.18 11.7 30.8 0.23 11.4 30.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Proteasome_A_N PF10584.9 CDI83212.1 - 2.5e-08 33.4 0.0 4.1e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF1645 PF07816.11 CDI83212.1 - 3.1e-05 24.7 13.3 4e-05 24.3 13.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1645) Bud13 PF09736.9 CDI83212.1 - 0.014 15.8 12.9 0.016 15.6 12.9 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Macoilin PF09726.9 CDI83212.1 - 0.014 14.0 17.3 0.018 13.6 17.3 1.0 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI83212.1 - 0.016 15.2 40.5 0.02 14.9 40.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FCP1_C PF09309.10 CDI83212.1 - 0.022 14.7 19.1 0.027 14.4 19.1 1.1 1 0 0 1 1 1 0 FCP1, C-terminal NBP1 PF08537.10 CDI83212.1 - 0.024 14.1 15.0 0.028 13.8 15.0 1.0 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 DUF913 PF06025.12 CDI83212.1 - 0.043 12.8 8.8 0.057 12.4 8.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) eIF-3_zeta PF05091.12 CDI83212.1 - 0.051 12.6 18.9 0.054 12.5 18.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PAP1 PF08601.10 CDI83212.1 - 0.061 13.0 22.8 0.077 12.7 22.8 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 GREB1 PF15782.5 CDI83212.1 - 0.092 9.9 22.3 0.11 9.6 22.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 CDI83212.1 - 0.13 11.3 17.6 0.15 11.1 17.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF2828 PF11443.8 CDI83212.1 - 0.16 10.0 11.7 0.16 10.0 11.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Apt1 PF10351.9 CDI83212.1 - 0.22 10.4 19.1 0.26 10.1 19.1 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DDRGK PF09756.9 CDI83212.1 - 0.27 10.8 18.4 0.32 10.6 18.4 1.1 1 0 0 1 1 1 0 DDRGK domain Cwf_Cwc_15 PF04889.12 CDI83212.1 - 0.33 10.6 17.2 0.42 10.3 17.2 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Dicty_REP PF05086.12 CDI83212.1 - 0.34 8.9 12.1 0.37 8.7 12.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Lin-8 PF03353.15 CDI83212.1 - 0.36 10.4 26.4 0.45 10.0 26.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Plasmodium_Vir PF05795.11 CDI83212.1 - 0.4 10.1 13.9 0.48 9.8 13.9 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF2126 PF09899.9 CDI83212.1 - 0.41 8.6 9.3 0.48 8.4 9.3 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) VIT1 PF01988.19 CDI83212.1 - 0.47 10.3 4.5 0.54 10.1 4.5 1.1 1 0 0 1 1 1 0 VIT family Peptidase_S64 PF08192.11 CDI83212.1 - 0.5 8.8 22.4 0.6 8.5 22.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 Peptidase_S49_N PF08496.10 CDI83212.1 - 0.53 10.3 11.1 0.63 10.1 11.1 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Het-C PF07217.11 CDI83212.1 - 0.57 8.6 9.4 0.64 8.5 9.4 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Presenilin PF01080.17 CDI83212.1 - 0.59 8.8 23.7 0.77 8.5 23.7 1.1 1 0 0 1 1 1 0 Presenilin DUF4746 PF15928.5 CDI83212.1 - 0.59 9.5 8.2 0.63 9.4 8.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) BRF1 PF07741.13 CDI83212.1 - 0.62 10.4 11.9 0.99 9.8 11.9 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain FHIPEP PF00771.20 CDI83212.1 - 0.64 8.4 7.9 0.7 8.3 7.9 1.1 1 0 0 1 1 1 0 FHIPEP family MDM10 PF12519.8 CDI83212.1 - 0.77 8.5 13.2 0.97 8.2 13.2 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 ECSIT PF06239.11 CDI83212.1 - 0.8 8.8 12.6 1 8.4 12.6 1.2 1 0 0 1 1 1 0 Evolutionarily conserved signalling intermediate in Toll pathway RED_N PF07808.13 CDI83212.1 - 0.87 9.1 15.8 1.1 8.8 15.8 1.3 1 0 0 1 1 1 0 RED-like protein N-terminal region PA26 PF04636.13 CDI83212.1 - 0.89 8.4 12.3 1.1 8.2 12.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Peptidase_U57 PF05582.12 CDI83212.1 - 0.94 8.7 11.1 1.1 8.5 11.1 1.1 1 0 0 1 1 1 0 YabG peptidase U57 BORG_CEP PF14957.6 CDI83212.1 - 0.97 10.6 17.5 1.4 10.1 17.5 1.1 1 0 0 1 1 1 0 Cdc42 effector SPX PF03105.19 CDI83212.1 - 1.3 8.9 22.5 1.5 8.7 22.5 1.0 1 0 0 1 1 1 0 SPX domain YjbH PF06082.11 CDI83212.1 - 1.4 7.6 11.7 1.6 7.4 11.7 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Cellulose_synt PF03552.14 CDI83212.1 - 1.5 7.2 6.3 1.6 7.1 6.3 1.1 1 0 0 1 1 1 0 Cellulose synthase PepSY_TM PF03929.16 CDI83212.1 - 1.6 8.3 8.6 1.8 8.1 8.6 1.1 1 0 0 1 1 1 0 PepSY-associated TM region TFB6 PF17110.5 CDI83212.1 - 1.7 8.4 10.7 2.6 7.8 10.7 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Miga PF10265.9 CDI83212.1 - 1.8 7.4 16.8 2.1 7.3 16.8 1.0 1 0 0 1 1 1 0 Mitoguardin Ureide_permease PF07168.11 CDI83212.1 - 2 7.1 6.1 2.1 7.0 6.1 1.2 1 0 0 1 1 1 0 Ureide permease DUF853 PF05872.12 CDI83212.1 - 3.1 6.3 11.2 3.6 6.1 11.2 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF4638 PF15472.6 CDI83212.1 - 3.7 7.2 15.6 4.4 7.0 15.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) MDM31_MDM32 PF08118.11 CDI83212.1 - 4 6.0 11.1 5.7 5.5 11.1 1.2 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Hydin_ADK PF17213.3 CDI83212.1 - 4.3 7.6 17.8 5.7 7.2 17.8 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain PAT1 PF09770.9 CDI83212.1 - 4.7 5.4 31.4 5.6 5.1 31.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Asparaginase_2 PF01112.18 CDI83212.1 - 5.6 5.9 8.1 6.2 5.7 8.1 1.2 1 0 0 1 1 1 0 Asparaginase GBP_C PF02841.14 CDI83212.1 - 6.2 6.1 26.4 7.6 5.8 26.4 1.0 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Membralin PF09746.9 CDI83212.1 - 6.6 5.7 10.9 8.2 5.4 10.9 1.2 1 0 0 1 1 1 0 Tumour-associated protein Orf78 PF06024.12 CDI83212.1 - 7.2 7.0 11.0 13 6.1 9.5 2.0 2 0 0 2 2 2 0 Orf78 (ac78) DUF4407 PF14362.6 CDI83212.1 - 7.5 5.8 19.2 8.6 5.6 19.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Polyoma_coat2 PF00761.20 CDI83212.1 - 8 6.1 13.5 9.5 5.8 13.5 1.1 1 0 0 1 1 1 0 Polyomavirus coat protein Ndc1_Nup PF09531.10 CDI83212.1 - 8.5 4.9 20.4 10 4.6 20.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup EMC3_TMCO1 PF01956.16 CDI83212.1 - 9.1 6.0 13.1 9.9 5.9 13.1 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like ALMT PF11744.8 CDI83212.1 - 9.2 5.0 15.4 11 4.7 15.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM222A PF15258.6 CDI83212.1 - 9.9 5.1 29.5 11 5.0 29.5 1.1 1 0 0 1 1 1 0 Protein family of FAM222A CBM_14 PF01607.24 CDI83221.1 - 0.017 15.3 0.1 0.035 14.3 0.1 1.4 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Tau95_N PF17682.1 CDI83221.1 - 0.048 13.9 0.1 0.048 13.9 0.1 2.5 2 0 0 2 2 2 0 Tau95 Triple barrel domain MDM10 PF12519.8 CDI83221.1 - 4 6.2 13.9 0.52 9.1 3.6 2.1 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 SURF6 PF04935.12 CDI83221.1 - 5.4 6.8 29.6 0.27 11.0 12.5 3.2 3 0 0 3 3 3 0 Surfeit locus protein 6 Ctr PF04145.15 CDI83221.1 - 6.4 7.4 14.2 2.1 8.9 1.8 2.4 2 1 0 2 2 2 0 Ctr copper transporter family CDC27 PF09507.10 CDI83221.1 - 9.5 5.5 28.0 13 5.1 28.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SR-25 PF10500.9 CDI83224.1 - 0.0054 16.4 15.7 0.0054 16.4 15.7 1.6 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Secretin_N_2 PF07655.13 CDI83224.1 - 0.26 11.8 14.8 0.82 10.3 14.8 1.8 1 0 0 1 1 1 0 Secretin N-terminal domain DUF4947 PF16305.5 CDI83224.1 - 2.4 8.2 5.3 4.4 7.3 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4947) Chorion_2 PF03964.15 CDI83224.1 - 5.8 7.8 16.8 3.4 8.6 8.2 2.6 2 1 0 2 2 2 0 Chorion family 2 DUF808 PF05661.12 CDI83227.1 - 0.015 14.4 0.1 1.2 8.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF808) YajC PF02699.15 CDI83227.1 - 0.03 14.2 1.2 0.1 12.5 1.2 1.9 1 0 0 1 1 1 0 Preprotein translocase subunit DREPP PF05558.12 CDI83227.1 - 0.47 10.3 5.2 0.2 11.5 2.6 1.7 2 0 0 2 2 2 0 DREPP plasma membrane polypeptide Trypan_PARP PF05887.11 CDI83227.1 - 2.8 7.9 7.1 5.9 6.9 7.1 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Rxt3 PF08642.10 CDI83238.1 - 0.0058 17.4 6.2 0.0073 17.1 6.2 1.2 1 0 0 1 1 1 1 Histone deacetylation protein Rxt3 RPN2_C PF18004.1 CDI83238.1 - 0.0073 16.2 11.7 0.0081 16.1 11.7 1.1 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain Mlh1_C PF16413.5 CDI83238.1 - 0.0077 15.6 9.0 0.0077 15.6 9.0 1.1 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus CSG2 PF16965.5 CDI83238.1 - 0.008 15.2 8.7 0.009 15.0 8.7 1.0 1 0 0 1 1 1 1 Ceramide synthase regulator Connexin PF00029.19 CDI83238.1 - 0.014 15.2 10.5 0.014 15.2 10.5 1.0 1 0 0 1 1 1 0 Connexin Afi1 PF07792.12 CDI83238.1 - 0.018 15.5 9.8 0.02 15.4 9.8 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking SpoIIP PF07454.11 CDI83238.1 - 0.029 13.8 14.9 0.03 13.8 14.9 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Folate_carrier PF01770.18 CDI83238.1 - 0.033 12.9 9.9 0.034 12.9 9.9 1.0 1 0 0 1 1 1 0 Reduced folate carrier OATP PF03137.20 CDI83238.1 - 0.044 12.1 8.3 0.05 11.9 8.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CLN3 PF02487.17 CDI83238.1 - 0.045 12.8 12.1 0.046 12.8 12.1 1.0 1 0 0 1 1 1 0 CLN3 protein MecA PF05389.12 CDI83238.1 - 0.049 13.2 11.7 0.056 13.1 11.7 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF5308 PF17233.2 CDI83238.1 - 0.058 13.6 10.1 0.062 13.5 10.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF2126 PF09899.9 CDI83238.1 - 0.062 11.4 9.3 0.065 11.3 9.3 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DDHD PF02862.17 CDI83238.1 - 0.068 13.3 12.5 0.07 13.3 12.5 1.0 1 0 0 1 1 1 0 DDHD domain Orf78 PF06024.12 CDI83238.1 - 0.078 13.3 8.2 0.12 12.7 8.2 1.3 1 0 0 1 1 1 0 Orf78 (ac78) DUF702 PF05142.12 CDI83238.1 - 0.1 13.1 13.8 0.16 12.5 13.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Kei1 PF08552.11 CDI83238.1 - 0.11 12.4 8.7 0.12 12.3 8.7 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Suf PF05843.14 CDI83238.1 - 0.11 12.5 19.8 0.14 12.1 19.8 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TERB2 PF15101.6 CDI83238.1 - 0.12 12.4 21.8 0.12 12.4 21.8 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 EOS1 PF12326.8 CDI83238.1 - 0.15 12.0 7.4 0.16 11.9 7.4 1.1 1 0 0 1 1 1 0 N-glycosylation protein FAM60A PF15396.6 CDI83238.1 - 0.16 12.0 12.7 0.18 11.8 12.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CTNNB1_binding PF08347.11 CDI83238.1 - 0.16 12.1 10.1 0.18 12.0 10.1 1.0 1 0 0 1 1 1 0 N-terminal CTNNB1 binding Nucleoside_tran PF01733.18 CDI83238.1 - 0.19 11.1 6.4 0.18 11.1 6.4 1.0 1 0 0 1 1 1 0 Nucleoside transporter SID-1_RNA_chan PF13965.6 CDI83238.1 - 0.19 10.1 8.9 0.2 10.1 8.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4638 PF15472.6 CDI83238.1 - 0.2 11.3 12.1 0.22 11.2 12.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF2417 PF10329.9 CDI83238.1 - 0.21 11.0 1.1 0.26 10.7 1.1 1.3 1 0 0 1 1 1 0 Region of unknown function (DUF2417) CPSF100_C PF13299.6 CDI83238.1 - 0.21 11.8 12.3 0.23 11.6 12.3 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FAM91_C PF14648.6 CDI83238.1 - 0.21 10.4 8.9 0.21 10.4 8.9 1.1 1 0 0 1 1 1 0 FAM91 C-terminus Ureide_permease PF07168.11 CDI83238.1 - 0.22 10.2 5.9 0.21 10.3 5.9 1.1 1 0 0 1 1 1 0 Ureide permease DDRGK PF09756.9 CDI83238.1 - 0.28 10.7 21.4 0.33 10.5 21.4 1.0 1 0 0 1 1 1 0 DDRGK domain Peroxin-13_N PF04088.13 CDI83238.1 - 0.28 11.4 8.8 0.34 11.2 8.8 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region FAM176 PF14851.6 CDI83238.1 - 0.28 10.8 10.3 0.33 10.6 10.3 1.2 1 0 0 1 1 1 0 FAM176 family DUF4471 PF14740.6 CDI83238.1 - 0.29 10.3 12.7 0.3 10.3 12.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) CCDC53 PF10152.9 CDI83238.1 - 0.3 11.5 16.5 0.35 11.3 16.5 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF853 PF05872.12 CDI83238.1 - 0.37 9.3 11.6 0.4 9.2 11.6 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) PRC2_HTH_1 PF18118.1 CDI83238.1 - 0.38 11.6 13.1 0.46 11.3 13.1 1.1 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Ndc1_Nup PF09531.10 CDI83238.1 - 0.41 9.3 12.5 0.42 9.3 12.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF2370 PF10176.9 CDI83238.1 - 0.43 10.2 5.6 0.45 10.1 5.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Tim54 PF11711.8 CDI83238.1 - 0.45 9.2 13.6 0.49 9.1 13.6 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Glt_symporter PF03616.14 CDI83238.1 - 0.47 9.1 5.1 0.48 9.1 5.1 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter Gti1_Pac2 PF09729.9 CDI83238.1 - 0.48 10.5 12.9 0.54 10.3 12.9 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family EIIBC-GUT_N PF03612.14 CDI83238.1 - 0.5 10.1 15.3 0.58 9.9 15.3 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Pinin_SDK_memA PF04696.13 CDI83238.1 - 0.51 10.4 31.6 0.64 10.1 31.6 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region Scs3p PF10261.9 CDI83238.1 - 0.51 9.8 5.3 0.53 9.7 5.3 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF2347 PF09804.9 CDI83238.1 - 0.66 9.5 8.3 0.72 9.4 8.3 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) ALMT PF11744.8 CDI83238.1 - 0.67 8.7 12.4 0.71 8.6 12.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter EMC3_TMCO1 PF01956.16 CDI83238.1 - 0.73 9.5 16.7 0.76 9.5 16.7 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like PIP5K PF01504.18 CDI83238.1 - 0.81 8.9 14.8 0.92 8.7 14.8 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Membralin PF09746.9 CDI83238.1 - 0.83 8.6 10.0 0.9 8.5 10.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF2828 PF11443.8 CDI83238.1 - 0.86 7.6 16.0 0.91 7.5 16.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) FHIPEP PF00771.20 CDI83238.1 - 0.86 8.0 10.2 0.89 7.9 10.2 1.2 1 0 0 1 1 1 0 FHIPEP family WASH-7_C PF14746.6 CDI83238.1 - 0.88 9.2 16.2 1.2 8.8 16.2 1.3 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal PepSY_TM PF03929.16 CDI83238.1 - 0.89 9.2 8.9 0.89 9.2 8.9 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Presenilin PF01080.17 CDI83238.1 - 0.95 8.2 20.2 1.1 7.9 20.2 1.0 1 0 0 1 1 1 0 Presenilin Peptidase_S49_N PF08496.10 CDI83238.1 - 1.1 9.4 16.1 1.2 9.1 16.1 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Pex14_N PF04695.13 CDI83238.1 - 1.1 9.9 28.7 1.3 9.7 28.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EPL1 PF10513.9 CDI83238.1 - 1.2 9.6 17.6 1.4 9.3 17.6 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF5385 PF17359.2 CDI83238.1 - 1.3 8.6 15.9 1.4 8.4 15.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5385) eIF-3_zeta PF05091.12 CDI83238.1 - 1.3 7.9 24.6 1.4 7.8 24.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ctr PF04145.15 CDI83238.1 - 1.3 9.6 10.0 1.4 9.5 10.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family DUF5523 PF17661.1 CDI83238.1 - 1.3 8.6 17.8 1.6 8.4 17.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Eapp_C PF10238.9 CDI83238.1 - 1.5 8.9 20.8 1.8 8.6 20.8 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein FliP PF00813.20 CDI83238.1 - 1.5 8.6 8.8 1.6 8.5 8.8 1.0 1 0 0 1 1 1 0 FliP family DUF913 PF06025.12 CDI83238.1 - 1.5 7.7 10.3 1.7 7.5 10.3 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DcuA_DcuB PF03605.14 CDI83238.1 - 1.7 7.4 5.1 1.7 7.5 5.1 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter RR_TM4-6 PF06459.12 CDI83238.1 - 1.7 8.4 18.3 2 8.2 18.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI83238.1 - 1.7 6.8 29.4 1.9 6.7 29.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3464 PF11947.8 CDI83238.1 - 1.7 8.4 17.7 2.1 8.1 17.7 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 SLC12 PF03522.15 CDI83238.1 - 1.7 7.5 18.0 1.9 7.4 18.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 RP-C_C PF11800.8 CDI83238.1 - 1.9 8.5 15.0 2.2 8.4 15.0 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region MPM1 PF17234.2 CDI83238.1 - 2 8.6 19.0 2.5 8.3 19.0 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 HCO3_cotransp PF00955.21 CDI83238.1 - 2 7.1 9.4 2.2 7.0 9.4 1.0 1 0 0 1 1 1 0 HCO3- transporter family Sin_N PF04801.13 CDI83238.1 - 2.1 7.5 26.7 2.1 7.5 26.7 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region G0-G1_switch_2 PF15103.6 CDI83238.1 - 2.1 8.8 12.4 3.1 8.3 12.4 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 EFTUD2 PF16004.5 CDI83238.1 - 2.2 8.9 18.1 2.7 8.6 18.1 1.1 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus DUF3408 PF11888.8 CDI83238.1 - 2.3 8.4 17.2 2.8 8.1 17.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) MAT1 PF06391.13 CDI83238.1 - 2.3 8.0 24.5 2.9 7.7 24.5 1.0 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 ATAD4 PF15321.6 CDI83238.1 - 2.9 9.3 11.9 3.8 8.9 11.9 1.2 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 G6B PF15096.6 CDI83238.1 - 3 7.6 4.9 3.1 7.5 4.9 1.1 1 0 0 1 1 1 0 G6B family GNAT_acetyltr_2 PF13718.6 CDI83238.1 - 3.1 7.2 14.5 3.9 6.8 14.5 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 MMU163 PF17119.5 CDI83238.1 - 3.1 6.9 8.7 3.6 6.7 8.7 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Otopetrin PF03189.13 CDI83238.1 - 3.1 6.5 12.0 3.1 6.5 12.0 1.0 1 0 0 1 1 1 0 Otopetrin Lin-8 PF03353.15 CDI83238.1 - 3.1 7.3 21.5 3.5 7.1 21.5 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 CDI83238.1 - 3.1 6.0 14.2 3.3 5.9 14.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Serinc PF03348.15 CDI83238.1 - 3.2 6.6 11.8 3.4 6.5 11.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) MMADHC PF10229.9 CDI83238.1 - 3.2 7.4 14.4 3.8 7.2 14.4 1.0 1 0 0 1 1 1 0 Methylmalonic aciduria and homocystinuria type D protein RBM39linker PF15519.6 CDI83238.1 - 3.3 8.9 16.2 4.7 8.4 16.2 1.3 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein CobT PF06213.12 CDI83238.1 - 3.5 6.9 27.0 4.2 6.7 27.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sec62 PF03839.16 CDI83238.1 - 4.1 6.9 13.4 4.7 6.7 13.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Velvet PF11754.8 CDI83238.1 - 4.2 7.3 17.7 4.6 7.1 17.7 1.0 1 0 0 1 1 1 0 Velvet factor Band_3_cyto PF07565.13 CDI83238.1 - 4.3 7.1 18.5 4.8 6.9 18.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain GREB1 PF15782.5 CDI83238.1 - 4.7 4.2 17.4 5.1 4.1 17.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4199 PF13858.6 CDI83238.1 - 4.9 7.5 9.4 5.7 7.3 9.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) PPL5 PF18168.1 CDI83238.1 - 5.1 6.3 13.4 5.6 6.2 13.4 1.0 1 0 0 1 1 1 0 Prim-pol family 5 BRF1 PF07741.13 CDI83238.1 - 5.3 7.5 14.9 7.6 7.0 14.9 1.3 1 0 0 1 1 1 0 Brf1-like TBP-binding domain V_ATPase_I PF01496.19 CDI83238.1 - 5.3 4.8 20.7 5.9 4.7 20.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ABC2_membrane_2 PF12679.7 CDI83238.1 - 5.4 6.2 8.0 5.3 6.2 8.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein TFIIA PF03153.13 CDI83238.1 - 6.4 6.7 47.0 7 6.5 47.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MDM10 PF12519.8 CDI83238.1 - 6.7 5.5 15.8 7.2 5.4 15.8 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 MDM31_MDM32 PF08118.11 CDI83238.1 - 7.2 5.1 14.8 8.6 4.9 14.8 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins RED_N PF07808.13 CDI83238.1 - 7.4 6.1 20.5 8.9 5.8 20.5 1.2 1 0 0 1 1 1 0 RED-like protein N-terminal region PigN PF04987.14 CDI83238.1 - 8.1 5.2 11.5 11 4.7 11.5 1.3 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Paf1 PF03985.13 CDI83238.1 - 8.9 5.2 21.3 10 5.0 21.3 1.0 1 0 0 1 1 1 0 Paf1 Macoilin PF09726.9 CDI83248.1 - 0.024 13.2 17.2 0.033 12.8 17.2 1.3 1 0 0 1 1 1 0 Macoilin family Lin-8 PF03353.15 CDI83248.1 - 0.054 13.1 10.2 0.064 12.8 10.2 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Rsm1 PF08600.10 CDI83248.1 - 0.087 13.0 1.7 0.16 12.2 1.2 1.7 1 1 0 1 1 1 0 Rsm1-like SelP_N PF04592.14 CDI83248.1 - 0.23 10.8 7.0 0.34 10.3 7.0 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Plasmodium_Vir PF05795.11 CDI83248.1 - 0.55 9.6 9.8 0.62 9.4 9.8 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TFIIF_alpha PF05793.12 CDI83248.1 - 0.59 8.7 20.6 0.76 8.3 20.6 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF1635 PF07795.11 CDI83248.1 - 1.7 8.5 11.5 2.4 8.0 11.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Apt1 PF10351.9 CDI83248.1 - 3 6.6 15.6 3.5 6.4 15.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOBP PF15279.6 CDI83248.1 - 3.6 8.1 16.8 4.5 7.8 16.8 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein SLC12 PF03522.15 CDI83248.1 - 5 6.0 12.2 5.9 5.8 12.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Utp14 PF04615.13 CDI83248.1 - 5.3 5.5 23.8 6.2 5.3 23.8 1.1 1 0 0 1 1 1 0 Utp14 protein NPR3 PF03666.13 CDI83248.1 - 7.9 5.1 11.4 9.6 4.9 11.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CCDC84 PF14968.6 CDI83248.1 - 9.1 5.8 12.9 11 5.6 12.9 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 DUF4551 PF15087.6 CDI83248.1 - 9.8 4.9 12.9 11 4.7 12.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Pex14_N PF04695.13 CDI83265.1 - 3.7 8.2 26.2 5.8 7.6 26.2 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3682 PF12446.8 CDI83265.1 - 4 7.9 34.6 4.5 7.8 34.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Presenilin PF01080.17 CDI83266.1 - 1.1 8.0 11.8 1.3 7.7 11.8 1.2 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI83266.1 - 1.4 8.9 7.4 1.6 8.7 7.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CLN3 PF02487.17 CDI83266.1 - 1.8 7.5 7.2 2.1 7.3 7.2 1.2 1 0 0 1 1 1 0 CLN3 protein IPK PF03770.16 CDI83266.1 - 3 7.6 11.5 3.7 7.4 11.5 1.1 1 0 0 1 1 1 0 Inositol polyphosphate kinase Med3 PF11593.8 CDI83281.1 - 0.009 15.2 9.8 0.009 15.2 9.8 7.3 2 1 4 7 7 7 1 Mediator complex subunit 3 fungal Spt20 PF12090.8 CDI83290.1 - 0.0044 16.7 11.8 0.0044 16.7 11.8 11.2 5 2 3 8 8 8 2 Spt20 family DUF2722 PF10846.8 CDI83290.1 - 0.0055 15.7 8.8 0.0055 15.7 8.8 12.1 4 3 5 10 10 10 1 Protein of unknown function (DUF2722) Oxidored_q3 PF00499.20 CDI83290.1 - 0.059 13.1 1.0 5.4 6.7 0.0 3.2 3 0 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 TT_ORF1 PF02956.14 CDI83298.1 - 0.0024 16.6 14.7 0.0024 16.6 14.7 2.7 2 1 1 3 3 3 1 TT viral orf 1 DUF4746 PF15928.5 CDI83298.1 - 0.54 9.6 0.0 0.54 9.6 0.0 3.2 4 1 0 4 4 4 0 Domain of unknown function (DUF4746) DUF3042 PF11240.8 CDI83298.1 - 1.5 8.9 0.0 1.5 8.9 0.0 4.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3042) CDC45 PF02724.14 CDI83298.1 - 2 6.6 34.4 1.8 6.8 4.3 2.5 2 1 0 2 2 2 0 CDC45-like protein DUF2151 PF10221.9 CDI83298.1 - 3.4 6.2 18.8 0.75 8.3 9.0 2.2 2 0 0 2 2 2 0 Cell cycle and development regulator SLC12 PF03522.15 CDI83298.1 - 6.3 5.7 45.5 1.1 8.1 9.1 2.9 3 0 0 3 3 3 0 Solute carrier family 12 Peptidase_S8 PF00082.22 CDI83306.1 - 1.3e-10 41.1 0.1 1.5e-10 40.9 0.1 1.0 1 0 0 1 1 1 1 Subtilase family RskA PF10099.9 CDI83318.1 - 6e-06 26.7 20.3 6e-06 26.7 20.3 5.7 2 2 4 6 6 1 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI83318.1 - 2.8e-05 23.8 30.0 4.1e-05 23.3 29.6 1.6 2 0 0 2 2 1 1 Spt20 family XAP5 PF04921.14 CDI83318.1 - 0.047 13.5 14.0 0.079 12.8 14.0 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator eIF-3_zeta PF05091.12 CDI83318.1 - 0.068 12.1 16.2 0.088 11.8 16.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rrn6 PF10214.9 CDI83318.1 - 0.07 11.6 18.1 0.072 11.6 18.1 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CDC45 PF02724.14 CDI83318.1 - 0.086 11.1 13.4 0.11 10.7 13.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 CDI83318.1 - 0.088 12.9 7.0 0.11 12.5 7.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MMR1 PF08505.10 CDI83318.1 - 0.1 12.9 24.6 0.16 12.2 24.6 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF5523 PF17661.1 CDI83318.1 - 0.1 12.3 11.3 0.14 11.8 11.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Connexin PF00029.19 CDI83318.1 - 0.12 12.2 6.8 0.17 11.7 6.8 1.2 1 0 0 1 1 1 0 Connexin Macoilin PF09726.9 CDI83318.1 - 0.15 10.6 25.5 0.26 9.8 25.5 1.3 1 0 0 1 1 1 0 Macoilin family EPL1 PF10513.9 CDI83318.1 - 0.15 12.5 14.9 0.28 11.6 14.9 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like SpoIIP PF07454.11 CDI83318.1 - 0.19 11.2 13.7 0.27 10.7 13.7 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Paf1 PF03985.13 CDI83318.1 - 0.19 10.7 17.7 0.27 10.2 17.7 1.2 1 0 0 1 1 1 0 Paf1 Miff PF05644.11 CDI83318.1 - 0.22 11.1 12.4 0.37 10.4 12.4 1.3 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Presenilin PF01080.17 CDI83318.1 - 0.4 9.4 19.6 0.58 8.9 19.6 1.3 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 CDI83318.1 - 0.49 8.7 4.4 0.65 8.3 4.4 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI83318.1 - 0.63 8.9 9.1 1.1 8.2 9.1 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Draxin PF15550.6 CDI83318.1 - 0.69 9.7 15.8 1.7 8.5 15.8 1.6 1 0 0 1 1 1 0 Draxin DUF1635 PF07795.11 CDI83318.1 - 0.83 9.5 16.5 1.6 8.5 16.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) MPM1 PF17234.2 CDI83318.1 - 0.95 9.7 17.5 1.5 9.1 17.5 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Hid1 PF12722.7 CDI83318.1 - 0.96 7.5 18.3 1.2 7.1 18.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CDI83318.1 - 1 6.4 23.4 1.2 6.2 23.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TERB2 PF15101.6 CDI83318.1 - 1.3 9.0 20.5 2.4 8.1 20.5 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Apt1 PF10351.9 CDI83318.1 - 1.5 7.6 19.2 2.4 6.9 19.2 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 CDI83318.1 - 1.5 8.3 21.9 2.2 7.7 21.9 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Band_3_cyto PF07565.13 CDI83318.1 - 1.6 8.5 11.9 2.2 8.0 11.9 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PDDEXK_6 PF04720.12 CDI83318.1 - 2.6 7.9 17.8 3.8 7.4 17.8 1.3 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Gti1_Pac2 PF09729.9 CDI83318.1 - 2.9 8.0 14.8 5.1 7.1 14.8 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4637 PF15470.6 CDI83318.1 - 3.2 7.5 13.7 5.7 6.6 13.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Paramyxo_ncap PF00973.19 CDI83318.1 - 3.4 6.5 15.9 4.5 6.1 15.9 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein XRN_M PF17846.1 CDI83318.1 - 3.6 6.4 10.6 5.2 5.9 10.6 1.3 1 0 0 1 1 1 0 Xrn1 helical domain ALMT PF11744.8 CDI83318.1 - 4.3 6.0 14.0 5.7 5.7 14.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 CDI83318.1 - 4.8 6.1 20.2 6.7 5.6 20.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Tim54 PF11711.8 CDI83318.1 - 5 5.8 17.0 9.3 4.9 17.0 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Plasmodium_Vir PF05795.11 CDI83318.1 - 5.5 6.3 10.9 7.4 5.9 10.9 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein V_ATPase_I PF01496.19 CDI83318.1 - 6 4.6 13.0 7.8 4.3 13.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI83318.1 - 7 5.6 11.7 11 4.9 11.7 1.3 1 0 0 1 1 1 0 CLN3 protein DUF4770 PF15994.5 CDI83318.1 - 7.5 6.7 14.8 12 6.1 14.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF4638 PF15472.6 CDI83318.1 - 7.7 6.2 11.9 11 5.7 11.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Peptidase_S64 PF08192.11 CDI83318.1 - 9.6 4.5 22.1 13 4.2 22.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 Sec62 PF03839.16 CDI83318.1 - 9.8 5.6 9.9 16 4.9 9.9 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 SARAF PF06682.12 CDI83326.1 - 2 8.0 32.0 0.13 11.9 10.9 2.4 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis SUIM_assoc PF16619.5 CDI83329.1 - 0.017 15.2 3.3 0.017 15.2 3.3 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 SARAF PF06682.12 CDI83329.1 - 1.3 8.6 20.0 2.5 7.6 19.7 1.5 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF572 PF04502.13 CDI83329.1 - 2.3 7.7 24.1 2.9 7.4 24.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) TCP PF03634.13 CDI83331.1 - 0.017 15.7 23.5 0.026 15.1 23.5 1.3 1 0 0 1 1 1 0 TCP family transcription factor SprA-related PF12118.8 CDI83331.1 - 0.042 13.0 44.6 0.053 12.7 44.6 1.1 1 0 0 1 1 1 0 SprA-related family TFIIA PF03153.13 CDI83331.1 - 0.099 12.6 42.4 0.13 12.2 42.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CCSAP PF15748.5 CDI83331.1 - 0.11 12.7 31.1 0.14 12.3 31.1 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated AF-4 PF05110.13 CDI83331.1 - 0.23 9.5 37.8 0.28 9.2 37.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PPP4R2 PF09184.11 CDI83331.1 - 0.39 10.3 25.2 0.52 9.9 25.2 1.1 1 0 0 1 1 1 0 PPP4R2 eIF-3_zeta PF05091.12 CDI83331.1 - 1.1 8.2 27.9 1.5 7.7 27.9 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CAC1F_C PF16885.5 CDI83331.1 - 2 8.0 22.8 2.5 7.7 22.8 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term XRN_M PF17846.1 CDI83331.1 - 2 7.3 21.4 2.4 7.0 21.4 1.1 1 0 0 1 1 1 0 Xrn1 helical domain GPCR_chapero_1 PF11904.8 CDI83331.1 - 2.1 7.7 18.3 2.7 7.3 18.3 1.2 1 0 0 1 1 1 0 GPCR-chaperone Nop53 PF07767.11 CDI83331.1 - 3.7 6.8 33.5 4.8 6.5 33.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF2828 PF11443.8 CDI83331.1 - 6.5 4.7 21.3 7.7 4.5 21.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CBP_BcsG PF11658.8 CDI83331.1 - 7.1 4.9 16.4 8.6 4.6 16.4 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG V_ATPase_I PF01496.19 CDI83331.1 - 7.6 4.3 28.1 11 3.8 28.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_23 PF13476.6 CDI83331.1 - 7.8 6.9 24.7 10 6.6 24.7 1.3 1 0 0 1 1 1 0 AAA domain DUF3381 PF11861.8 CDI83331.1 - 7.8 6.3 30.9 13 5.5 30.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF2126 PF09899.9 CDI83368.1 - 0.0028 15.8 8.6 0.0032 15.6 8.6 1.2 1 0 0 1 1 1 1 Putative amidoligase enzyme (DUF2126) DUF677 PF05055.12 CDI83368.1 - 0.0041 16.1 0.4 0.0041 16.1 0.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF677) N6_N4_Mtase PF01555.18 CDI83368.1 - 0.072 12.8 0.0 0.37 10.5 0.0 1.9 1 1 0 1 1 1 0 DNA methylase ALMT PF11744.8 CDI83368.1 - 0.55 9.0 14.6 0.75 8.6 14.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 CDI83368.1 - 1.1 8.4 8.2 1.9 7.7 8.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Hamartin PF04388.12 CDI83368.1 - 1.9 7.1 32.3 2.2 6.9 32.3 1.0 1 0 0 1 1 1 0 Hamartin protein LMBR1 PF04791.16 CDI83368.1 - 2.8 6.7 5.5 3 6.6 5.5 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein SARAF PF06682.12 CDI83368.1 - 3.9 7.0 23.4 6.8 6.2 23.3 1.6 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4045 PF13254.6 CDI83368.1 - 6.5 6.3 30.8 7.9 6.0 30.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Presenilin PF01080.17 CDI83376.1 - 0.023 13.5 41.7 0.023 13.5 41.7 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI83376.1 - 0.1 12.4 34.9 0.14 12.0 34.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4045 PF13254.6 CDI83376.1 - 0.23 11.1 32.0 0.25 10.9 32.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PAT1 PF09770.9 CDI83376.1 - 0.26 9.5 60.1 0.25 9.6 60.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ALMT PF11744.8 CDI83376.1 - 0.65 8.8 28.3 0.76 8.5 28.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Macoilin PF09726.9 CDI83376.1 - 0.71 8.4 30.2 0.79 8.2 30.2 1.1 1 0 0 1 1 1 0 Macoilin family MCM_bind PF09739.9 CDI83376.1 - 1.1 7.6 30.4 1.5 7.2 30.4 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Totivirus_coat PF05518.11 CDI83376.1 - 1.2 7.1 14.8 1.2 7.1 14.8 1.0 1 0 0 1 1 1 0 Totivirus coat protein GAGA_bind PF06217.12 CDI83376.1 - 1.3 9.3 31.2 1.7 8.9 31.2 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Peptidase_S64 PF08192.11 CDI83376.1 - 1.3 7.4 32.5 1.9 6.9 32.5 1.4 1 0 0 1 1 1 0 Peptidase family S64 GREB1 PF15782.5 CDI83376.1 - 1.4 5.9 40.5 1.5 5.9 40.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 CDI83376.1 - 1.6 7.7 42.4 1.6 7.6 42.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PNISR PF15996.5 CDI83376.1 - 1.6 8.9 42.9 1.7 8.8 42.9 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR CDC45 PF02724.14 CDI83376.1 - 1.9 6.7 38.2 2.4 6.4 38.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Hamartin PF04388.12 CDI83376.1 - 2.6 6.6 38.4 2.6 6.6 38.4 1.0 1 0 0 1 1 1 0 Hamartin protein Caldesmon PF02029.15 CDI83376.1 - 3.9 6.1 38.9 4.1 6.1 38.9 1.1 1 0 0 1 1 1 0 Caldesmon Endostatin PF06482.11 CDI83376.1 - 4 6.8 35.6 5.7 6.3 35.6 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Asp-B-Hydro_N PF05279.11 CDI83376.1 - 4.1 7.4 26.7 4.5 7.3 26.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region AF-4 PF05110.13 CDI83376.1 - 4.2 5.3 47.8 4.3 5.3 47.8 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Membralin PF09746.9 CDI83376.1 - 5.2 6.0 26.6 6 5.8 26.6 1.2 1 0 0 1 1 1 0 Tumour-associated protein LAP1C PF05609.12 CDI83376.1 - 5.5 6.0 41.1 6.3 5.8 41.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Dicty_REP PF05086.12 CDI83376.1 - 5.6 4.8 24.4 5.9 4.7 24.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SPX PF03105.19 CDI83376.1 - 5.7 6.8 32.8 6.6 6.5 32.8 1.1 1 0 0 1 1 1 0 SPX domain Raftlin PF15250.6 CDI83376.1 - 9.8 4.8 33.9 12 4.5 33.9 1.0 1 0 0 1 1 1 0 Raftlin STI1 PF17830.1 CDI83400.1 - 0.0076 16.2 5.8 0.0076 16.2 5.8 2.4 2 0 0 2 2 2 1 STI1 domain ubiquitin PF00240.23 CDI83400.1 - 0.0092 15.7 1.9 0.015 15.0 1.9 1.3 1 0 0 1 1 1 1 Ubiquitin family Ndc1_Nup PF09531.10 CDI83400.1 - 0.084 11.6 3.8 0.11 11.2 3.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hydin_ADK PF17213.3 CDI83400.1 - 0.31 11.3 12.3 0.46 10.7 12.3 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain API5 PF05918.11 CDI83400.1 - 0.33 9.7 4.7 0.43 9.3 4.7 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF2722 PF10846.8 CDI83400.1 - 1.3 7.9 16.3 0.039 12.9 10.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) ARS2 PF04959.13 CDI83400.1 - 1.7 9.0 8.7 3.5 7.9 8.7 1.5 1 0 0 1 1 1 0 Arsenite-resistance protein 2 SAPS PF04499.15 CDI83400.1 - 2.6 6.7 6.6 3.7 6.2 6.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF572 PF04502.13 CDI83400.1 - 6 6.4 9.6 8.4 5.9 9.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) RskA PF10099.9 CDI83400.1 - 6.1 7.1 30.5 35 4.6 30.5 2.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI83400.1 - 7.2 5.3 9.9 9.8 4.8 9.9 1.2 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI83400.1 - 8.2 6.3 25.0 2 8.3 22.2 1.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Fer4_18 PF13746.6 CDI83403.1 - 0.049 13.8 1.4 0.11 12.7 1.4 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Metallothio_2 PF01439.18 CDI83403.1 - 0.069 14.1 0.3 0.069 14.1 0.3 3.1 3 0 0 3 3 3 0 Metallothionein CLN3 PF02487.17 CDI83403.1 - 0.087 11.9 0.4 0.14 11.2 0.4 1.4 1 0 0 1 1 1 0 CLN3 protein SARAF PF06682.12 CDI83403.1 - 0.16 11.6 7.5 0.093 12.4 1.2 2.2 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Ly49 PF08391.10 CDI83403.1 - 0.21 12.0 7.8 0.44 10.9 7.8 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region BatD PF13584.6 CDI83403.1 - 0.32 9.8 8.6 0.016 14.1 2.5 1.9 1 1 1 2 2 2 0 Oxygen tolerance V_ATPase_I PF01496.19 CDI83403.1 - 0.48 8.3 3.8 0.69 7.8 3.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SIT PF15330.6 CDI83403.1 - 1.1 9.8 14.1 0.32 11.5 8.9 2.2 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Tmemb_9 PF05434.11 CDI83403.1 - 4.6 7.1 11.9 12 5.8 11.9 1.6 1 0 0 1 1 1 0 TMEM9 RIFIN PF02009.16 CDI83403.1 - 5.1 6.9 11.6 0.91 9.4 5.0 2.1 2 0 0 2 2 2 0 Rifin RRM_1 PF00076.22 CDI83404.1 - 1.5e-08 34.3 0.0 2.9e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Hid1 PF12722.7 CDI83404.1 - 0.31 9.1 11.4 0.48 8.5 11.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Mem_trans PF03547.18 CDI83404.1 - 0.33 9.3 3.5 0.58 8.5 3.5 1.4 1 0 0 1 1 1 0 Membrane transport protein GREB1 PF15782.5 CDI83404.1 - 1.1 6.2 8.9 1.3 6.0 8.9 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 CDI83404.1 - 2.6 7.0 11.7 5.3 6.0 11.7 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Apt1 PF10351.9 CDI83404.1 - 4.4 6.0 13.8 6 5.6 13.8 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain RR_TM4-6 PF06459.12 CDI83404.1 - 6.7 6.5 18.0 0.44 10.3 11.7 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF4667 PF15700.5 CDI83424.1 - 0.0024 18.0 8.4 0.0036 17.4 8.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4667) RskA PF10099.9 CDI83424.1 - 0.0062 16.9 3.9 0.0079 16.5 3.9 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA BUD22 PF09073.10 CDI83424.1 - 0.008 15.6 5.3 0.01 15.2 5.3 1.1 1 0 0 1 1 1 1 BUD22 Spt20 PF12090.8 CDI83424.1 - 0.0086 15.7 7.3 0.011 15.4 7.3 1.1 1 0 0 1 1 1 1 Spt20 family Lin-8 PF03353.15 CDI83424.1 - 0.009 15.6 1.9 0.01 15.4 1.9 1.1 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist SARAF PF06682.12 CDI83424.1 - 0.031 13.9 12.1 0.039 13.6 12.1 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Apt1 PF10351.9 CDI83424.1 - 0.032 13.1 8.3 0.037 12.9 8.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Sporozoite_P67 PF05642.11 CDI83424.1 - 0.049 11.7 7.3 0.058 11.5 7.3 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SPX PF03105.19 CDI83424.1 - 0.055 13.4 8.9 0.066 13.1 8.9 1.1 1 0 0 1 1 1 0 SPX domain RRM_1 PF00076.22 CDI83424.1 - 0.06 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RAP1 PF07218.11 CDI83424.1 - 0.2 9.9 10.2 0.21 9.9 10.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Presenilin PF01080.17 CDI83424.1 - 0.34 9.6 5.0 0.43 9.3 5.0 1.1 1 0 0 1 1 1 0 Presenilin Secretin_N_2 PF07655.13 CDI83424.1 - 5.8 7.5 25.8 2.9 8.5 20.8 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain PrsW-protease PF13367.6 CDI83433.1 - 0.12 11.9 0.2 0.18 11.3 0.2 1.2 1 0 0 1 1 1 0 PrsW family intramembrane metalloprotease Menin PF05053.13 CDI83433.1 - 0.12 10.7 5.6 0.15 10.4 5.6 1.0 1 0 0 1 1 1 0 Menin TFIIA PF03153.13 CDI83433.1 - 0.14 12.1 18.1 0.17 11.9 18.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3801 PF12687.7 CDI83433.1 - 1.4 9.0 6.5 1.6 8.8 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) Exonuc_VII_L PF02601.15 CDI83433.1 - 1.4 8.4 9.6 1.8 8.0 9.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit SLD3 PF08639.10 CDI83443.1 - 0.067 11.9 27.5 0.084 11.6 27.5 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 Peptidase_M56 PF05569.11 CDI83443.1 - 1.6 7.9 10.8 1.7 7.7 10.8 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 Orf78 PF06024.12 CDI83443.1 - 3.9 7.8 21.4 3.6 7.9 4.4 2.6 1 1 1 2 2 2 0 Orf78 (ac78) SLC12 PF03522.15 CDI83443.1 - 4.1 6.3 27.7 5.2 6.0 27.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Afi1 PF07792.12 CDI83443.1 - 8.8 6.8 25.6 1.1 9.7 11.3 2.0 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CDC45 PF02724.14 CDI83450.1 - 0.00025 19.5 34.1 0.00025 19.5 34.1 1.0 1 0 0 1 1 1 1 CDC45-like protein YL1 PF05764.13 CDI83450.1 - 0.0029 17.7 45.8 0.0041 17.3 45.8 1.2 1 0 0 1 1 1 1 YL1 nuclear protein TFIIF_alpha PF05793.12 CDI83450.1 - 0.0078 14.9 48.3 0.011 14.3 48.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop53 PF07767.11 CDI83450.1 - 0.0092 15.4 51.9 0.01 15.3 51.9 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Merozoite_SPAM PF07133.11 CDI83450.1 - 0.022 14.8 64.9 0.027 14.5 64.9 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) SDA1 PF05285.12 CDI83450.1 - 0.045 13.2 47.9 0.052 13.0 47.9 1.1 1 0 0 1 1 1 0 SDA1 CCSAP PF15748.5 CDI83450.1 - 0.056 13.6 30.5 0.061 13.5 30.5 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Presenilin PF01080.17 CDI83450.1 - 0.23 10.2 25.4 0.23 10.2 25.4 1.1 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 CDI83450.1 - 0.3 9.3 51.8 0.35 9.0 51.8 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2207 PF09972.9 CDI83450.1 - 0.33 9.7 7.3 0.42 9.3 7.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) CCDC106 PF15794.5 CDI83450.1 - 0.41 10.3 30.8 0.55 9.9 30.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF3807 PF12720.7 CDI83450.1 - 0.63 10.3 38.7 0.84 9.9 38.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) CAS_C PF12026.8 CDI83450.1 - 1.3 9.0 13.6 1.6 8.8 13.6 1.2 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain Mpp10 PF04006.12 CDI83450.1 - 1.3 7.3 56.4 1.6 7.1 56.4 1.0 1 0 0 1 1 1 0 Mpp10 protein Draxin PF15550.6 CDI83450.1 - 1.5 8.6 20.3 1.6 8.5 20.3 1.0 1 0 0 1 1 1 0 Draxin Dsh_C PF12316.8 CDI83450.1 - 1.9 8.8 8.8 2.5 8.5 8.8 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal CDC27 PF09507.10 CDI83450.1 - 2.6 7.4 52.2 3 7.1 52.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RR_TM4-6 PF06459.12 CDI83450.1 - 3.6 7.3 45.3 4.2 7.1 45.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LTV PF04180.14 CDI83450.1 - 4.1 7.0 34.1 5.3 6.7 34.1 1.2 1 0 0 1 1 1 0 Low temperature viability protein GAGA_bind PF06217.12 CDI83450.1 - 4.5 7.5 26.1 5.2 7.3 26.1 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Hydin_ADK PF17213.3 CDI83450.1 - 5.5 7.2 15.7 6.7 6.9 15.7 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain AF-4 PF05110.13 CDI83450.1 - 5.7 4.9 28.0 6.6 4.7 28.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FRQ PF09421.10 CDI83450.1 - 5.9 4.8 21.3 7.3 4.5 21.3 1.0 1 0 0 1 1 1 0 Frequency clock protein SRP-alpha_N PF04086.13 CDI83450.1 - 5.9 6.7 32.4 7.1 6.5 32.4 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SOBP PF15279.6 CDI83450.1 - 6.9 7.2 10.6 7.5 7.1 10.6 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein SID-1_RNA_chan PF13965.6 CDI83450.1 - 7.5 4.8 12.2 8.6 4.6 12.2 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4045 PF13254.6 CDI83450.1 - 8.7 5.9 29.3 9.7 5.7 29.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Pex2_Pex12 PF04757.14 CDI83456.1 - 6e-11 42.4 0.0 6e-11 42.4 0.0 2.4 2 1 1 3 3 3 1 Pex2 / Pex12 amino terminal region RskA PF10099.9 CDI83456.1 - 0.0079 16.5 9.1 0.0079 16.5 9.1 6.0 1 1 3 4 4 4 2 Anti-sigma-K factor rskA DUF2298 PF10060.9 CDI83456.1 - 0.21 10.3 0.0 0.37 9.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) Hid1 PF12722.7 CDI83456.1 - 2.7 6.0 57.2 0.046 11.8 27.8 2.2 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Utp14 PF04615.13 CDI83456.1 - 8.5 4.8 66.6 0.21 10.1 58.6 1.9 2 0 0 2 2 2 0 Utp14 protein HCO3_cotransp PF00955.21 CDI83462.1 - 0.0081 15.0 0.3 0.011 14.7 0.3 1.1 1 0 0 1 1 1 1 HCO3- transporter family NPR3 PF03666.13 CDI83462.1 - 0.012 14.4 9.8 0.02 13.7 9.8 1.5 1 1 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ctr PF04145.15 CDI83462.1 - 0.094 13.3 0.6 0.24 12.0 0.6 1.8 1 1 0 1 1 1 0 Ctr copper transporter family DUF3464 PF11947.8 CDI83462.1 - 0.35 10.6 3.9 0.16 11.7 0.2 2.1 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DNA_pol_phi PF04931.13 CDI83462.1 - 0.39 8.7 15.3 0.66 8.0 15.3 1.3 1 0 0 1 1 1 0 DNA polymerase phi Paramyxo_ncap PF00973.19 CDI83462.1 - 1.5 7.6 5.1 2.3 7.0 5.1 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PIEZO PF15917.5 CDI83462.1 - 2.1 7.7 6.9 0.4 10.1 3.4 1.6 2 0 0 2 2 2 0 Piezo CDC27 PF09507.10 CDI83462.1 - 2.2 7.6 26.0 2.7 7.3 26.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RskA PF10099.9 CDI83462.1 - 2.4 8.4 15.2 9.7 6.4 15.5 1.8 1 1 0 1 1 1 0 Anti-sigma-K factor rskA PP_M1 PF03012.14 CDI83462.1 - 2.7 7.4 10.6 0.033 13.7 1.8 1.8 2 0 0 2 2 2 0 Phosphoprotein Nop14 PF04147.12 CDI83462.1 - 5 5.2 19.5 5.6 5.1 19.5 1.1 1 0 0 1 1 1 0 Nop14-like family Connexin PF00029.19 CDI83462.1 - 5.3 6.7 9.0 9.7 5.9 8.9 1.7 1 1 0 1 1 1 0 Connexin ketoacyl-synt PF00109.26 CDI83470.1 - 5e-63 213.0 0.0 1e-62 212.0 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CDI83470.1 - 1.5e-48 165.1 0.2 5.6e-48 163.2 0.0 2.0 2 0 0 2 2 2 1 KR domain Ketoacyl-synt_C PF02801.22 CDI83470.1 - 8.3e-31 106.4 0.2 1.7e-30 105.5 0.2 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 CDI83470.1 - 2.2e-28 99.1 0.0 7.4e-26 90.9 0.0 2.7 3 0 0 3 3 3 2 Male sterility protein PP-binding PF00550.25 CDI83470.1 - 3.5e-11 43.3 0.4 9.1e-11 42.0 0.4 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 CDI83470.1 - 2.4e-09 36.9 0.0 4.5e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDI83470.1 - 8.6e-07 28.7 0.1 3.9e-06 26.6 0.0 2.1 3 0 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CDI83470.1 - 0.00031 20.3 0.4 0.095 12.1 0.0 3.1 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CDI83470.1 - 0.00039 19.6 0.0 0.005 16.0 0.0 2.4 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 CDI83470.1 - 0.032 13.6 0.0 0.074 12.4 0.0 1.6 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Activator_LAG-3 PF11498.8 CDI83471.1 - 0.24 10.3 79.5 0.082 11.9 2.4 2.4 2 0 0 2 2 2 0 Transcriptional activator LAG-3 RseC_MucC PF04246.12 CDI83473.1 - 8.7 6.3 8.5 10 6.1 6.5 2.2 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC TAF4 PF05236.14 CDI83491.1 - 0.00046 20.0 12.5 0.00046 20.0 12.5 2.5 2 1 0 2 2 1 1 Transcription initiation factor TFIID component TAF4 family SR-25 PF10500.9 CDI83491.1 - 0.0037 16.9 29.1 0.0037 16.9 29.1 3.2 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 CDI83491.1 - 0.0058 14.8 49.5 0.081 11.0 16.4 2.2 2 0 0 2 2 2 2 AF-4 proto-oncoprotein SLC12 PF03522.15 CDI83491.1 - 0.0065 15.5 30.0 0.11 11.6 8.5 2.1 2 0 0 2 2 2 2 Solute carrier family 12 LTV PF04180.14 CDI83491.1 - 0.0082 15.9 33.0 0.08 12.7 18.4 2.2 2 0 0 2 2 2 2 Low temperature viability protein RR_TM4-6 PF06459.12 CDI83491.1 - 0.0098 15.8 38.9 0.23 11.2 16.0 2.2 2 0 0 2 2 2 2 Ryanodine Receptor TM 4-6 PNISR PF15996.5 CDI83491.1 - 0.014 15.7 39.0 0.064 13.5 10.8 2.4 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR CDC45 PF02724.14 CDI83491.1 - 0.027 12.8 39.0 0.17 10.1 9.2 2.1 2 0 0 2 2 2 0 CDC45-like protein Presenilin PF01080.17 CDI83491.1 - 0.028 13.2 41.2 0.035 12.9 17.0 2.2 2 0 0 2 2 2 0 Presenilin Asp-B-Hydro_N PF05279.11 CDI83491.1 - 0.18 11.9 31.5 1.2 9.1 10.5 2.1 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region DUF2052 PF09747.9 CDI83491.1 - 0.34 11.0 48.7 0.46 10.6 18.9 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Zip PF02535.22 CDI83491.1 - 0.35 10.1 22.1 0.22 10.7 6.2 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter DUF3807 PF12720.7 CDI83491.1 - 0.67 10.2 46.8 2.7 8.2 16.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Plasmodium_Vir PF05795.11 CDI83491.1 - 0.83 9.0 28.5 0.15 11.5 12.2 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DUF4647 PF15504.6 CDI83491.1 - 1.3 8.0 33.9 0.54 9.3 10.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) SDA1 PF05285.12 CDI83491.1 - 1.7 8.0 38.3 2.7 7.3 17.7 2.3 2 0 0 2 2 2 0 SDA1 CCSAP PF15748.5 CDI83491.1 - 2.5 8.2 51.9 2.3 8.3 20.9 2.3 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Menin PF05053.13 CDI83491.1 - 7.7 4.7 33.4 4.3 5.6 13.7 2.1 2 0 0 2 2 2 0 Menin DUF1645 PF07816.11 CDI83491.1 - 7.9 7.0 43.0 0.11 13.1 17.6 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1645) INSIG PF07281.12 CDI83499.1 - 9.4 5.8 25.0 0.2 11.3 0.4 4.3 3 1 1 4 4 4 0 Insulin-induced protein (INSIG) VIT1 PF01988.19 CDI83510.1 - 0.017 15.0 1.3 0.017 15.0 1.3 1.0 1 0 0 1 1 1 0 VIT family RskA PF10099.9 CDI83510.1 - 0.02 15.2 7.9 0.022 15.1 7.9 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA FAM176 PF14851.6 CDI83510.1 - 0.073 12.7 2.6 0.072 12.8 2.6 1.1 1 0 0 1 1 1 0 FAM176 family PEX11 PF05648.14 CDI83510.1 - 0.086 12.3 5.8 0.099 12.1 5.8 1.0 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) DUF4820 PF16091.5 CDI83510.1 - 0.095 12.1 6.9 0.1 12.0 6.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Sec16 PF12932.7 CDI83510.1 - 0.1 13.2 2.6 0.11 13.0 2.6 1.1 1 0 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region Gaa1 PF04114.14 CDI83510.1 - 0.1 11.6 1.1 0.1 11.6 1.1 1.0 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component DUF533 PF04391.12 CDI83510.1 - 0.11 12.1 10.8 0.12 12.0 10.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF533) HA2 PF04408.23 CDI83510.1 - 0.11 12.8 5.0 0.14 12.5 5.0 1.1 1 0 0 1 1 1 0 Helicase associated domain (HA2) Orf78 PF06024.12 CDI83510.1 - 0.12 12.7 3.9 0.13 12.5 3.9 1.1 1 0 0 1 1 1 0 Orf78 (ac78) BRF1 PF07741.13 CDI83510.1 - 0.17 12.2 8.1 0.19 12.1 8.1 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain EIIBC-GUT_N PF03612.14 CDI83510.1 - 0.21 11.3 7.7 0.22 11.3 7.7 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus RuvC_III PF18541.1 CDI83510.1 - 0.21 11.5 7.1 0.24 11.3 7.1 1.0 1 0 0 1 1 1 0 RuvC endonuclease subdomain 3 EphA2_TM PF14575.6 CDI83510.1 - 0.23 12.4 2.1 0.29 12.1 2.1 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF1840 PF08895.11 CDI83510.1 - 0.24 11.7 7.2 0.27 11.6 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) FHIPEP PF00771.20 CDI83510.1 - 0.24 9.8 6.4 0.25 9.8 6.4 1.0 1 0 0 1 1 1 0 FHIPEP family dsDNA_bind PF01984.20 CDI83510.1 - 0.32 11.3 21.2 0.4 11.0 21.2 1.1 1 0 0 1 1 1 0 Double-stranded DNA-binding domain Peptidase_S49_N PF08496.10 CDI83510.1 - 0.38 10.8 8.6 0.42 10.7 8.6 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ketoacyl-synt_2 PF13723.6 CDI83510.1 - 0.4 10.3 9.1 0.4 10.3 9.1 1.0 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain CPSF100_C PF13299.6 CDI83510.1 - 0.41 10.8 6.9 0.44 10.7 6.9 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2722 PF10846.8 CDI83510.1 - 0.43 9.5 21.1 0.43 9.5 21.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF4834 PF16118.5 CDI83510.1 - 0.43 11.6 8.1 0.49 11.4 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DcuC PF03606.15 CDI83510.1 - 0.44 8.9 2.4 0.49 8.8 2.4 1.0 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier Coilin_N PF15862.5 CDI83510.1 - 0.45 10.3 10.7 0.48 10.2 10.7 1.1 1 0 0 1 1 1 0 Coilin N-terminus DUF4199 PF13858.6 CDI83510.1 - 0.46 10.9 5.8 0.47 10.8 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Pex14_N PF04695.13 CDI83510.1 - 0.52 10.9 12.0 0.62 10.7 12.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CTU2 PF10288.9 CDI83510.1 - 0.62 10.3 9.4 0.73 10.1 9.4 1.1 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Nucleoside_tran PF01733.18 CDI83510.1 - 0.68 9.3 2.5 0.67 9.3 2.5 1.0 1 0 0 1 1 1 0 Nucleoside transporter Folate_carrier PF01770.18 CDI83510.1 - 0.86 8.3 4.7 0.9 8.2 4.7 1.1 1 0 0 1 1 1 0 Reduced folate carrier Glt_symporter PF03616.14 CDI83510.1 - 0.96 8.1 3.6 0.99 8.0 3.6 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter Suf PF05843.14 CDI83510.1 - 1 9.3 12.7 1.1 9.2 12.7 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3464 PF11947.8 CDI83510.1 - 1 9.1 8.0 1.1 9.0 8.0 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 OATP PF03137.20 CDI83510.1 - 1.1 7.5 4.3 1 7.6 4.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF775 PF05603.12 CDI83510.1 - 1.1 8.8 10.0 1 8.8 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) SpoIIP PF07454.11 CDI83510.1 - 1.1 8.6 9.5 1.2 8.6 9.5 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PigN PF04987.14 CDI83510.1 - 1.7 7.4 4.2 1.6 7.5 4.2 1.0 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Presenilin PF01080.17 CDI83510.1 - 2.1 7.0 9.3 2.2 6.9 9.3 1.0 1 0 0 1 1 1 0 Presenilin Ctr PF04145.15 CDI83510.1 - 2.4 8.8 4.4 2.3 8.8 4.4 1.1 1 0 0 1 1 1 0 Ctr copper transporter family DcuA_DcuB PF03605.14 CDI83510.1 - 2.4 7.0 3.7 2.4 6.9 3.7 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter EOS1 PF12326.8 CDI83510.1 - 2.7 7.9 4.4 2.8 7.8 4.4 1.1 1 0 0 1 1 1 0 N-glycosylation protein AIF_C PF14721.6 CDI83510.1 - 3.1 8.2 7.7 3.5 8.0 7.7 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CLN3 PF02487.17 CDI83510.1 - 4.1 6.3 5.9 4 6.4 5.9 1.0 1 0 0 1 1 1 0 CLN3 protein ABC2_membrane_2 PF12679.7 CDI83510.1 - 4.2 6.6 6.4 4.7 6.4 6.4 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4175 PF13779.6 CDI83510.1 - 4.2 5.1 20.4 4.3 5.1 20.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) MscS_TM PF12794.7 CDI83510.1 - 4.7 6.0 9.7 5 5.9 9.7 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 TFIIA PF03153.13 CDI83510.1 - 7 6.5 25.1 7.1 6.5 25.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GTA_holin_3TM PF11351.8 CDI83510.1 - 7.2 7.2 11.2 8.7 6.9 11.2 1.1 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release Asparaginase_2 PF01112.18 CDI83510.1 - 9.3 5.2 8.0 9.5 5.1 8.0 1.0 1 0 0 1 1 1 0 Asparaginase Trp_oprn_chp PF09534.10 CDI83525.1 - 0.0003 20.6 2.1 0.0003 20.6 2.1 4.2 3 1 0 4 4 4 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) rve PF00665.26 CDI83526.1 - 3.9e-11 43.2 0.0 5.4e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDI83526.1 - 0.1 12.4 0.1 0.18 11.6 0.1 1.3 1 0 0 1 1 1 0 Integrase core domain RT_RNaseH PF17917.1 CDI83527.1 - 3.1e-19 69.2 0.0 5.9e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDI83527.1 - 3.1e-18 65.7 0.0 5.6e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDI83527.1 - 1.7e-15 57.1 0.0 3.2e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 CDI83528.1 - 5.7e-08 33.2 0.0 1.2e-07 32.1 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDI83528.1 - 1.3e-07 32.2 0.0 2.5e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 CDI83528.1 - 0.00032 20.5 0.0 0.00063 19.5 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.20 CDI83528.1 - 0.004 17.4 0.0 0.017 15.4 0.0 2.0 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease PF09668.10 CDI83528.1 - 0.096 12.5 0.0 0.27 11.0 0.0 1.7 2 0 0 2 2 2 0 Aspartyl protease Fra10Ac1 PF09725.9 CDI83530.1 - 2.8e-13 50.1 7.2 4.8e-11 42.8 0.1 3.0 3 0 0 3 3 3 2 Folate-sensitive fragile site protein Fra10Ac1 DUF2214 PF09980.9 CDI83554.1 - 1.1 9.1 0.0 1.1 9.1 0.0 3.7 5 0 0 5 5 5 0 Predicted membrane protein (DUF2214) Ribosomal_60s PF00428.19 CDI83554.1 - 2.9 8.6 22.2 6.5 7.4 8.8 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein HTH_ParB PF17762.1 CDI83556.1 - 0.0031 17.3 8.7 0.0031 17.3 8.7 1.7 1 1 0 1 1 1 1 HTH domain found in ParB protein TT_ORF1 PF02956.14 CDI83556.1 - 0.022 13.5 4.6 0.025 13.3 4.6 1.1 1 0 0 1 1 1 0 TT viral orf 1 V_ATPase_I PF01496.19 CDI83556.1 - 0.028 12.3 3.5 0.035 12.1 3.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RTX PF02382.15 CDI83556.1 - 0.032 13.9 0.9 0.032 13.9 0.9 4.1 2 1 2 4 4 1 0 N-terminal domain in RTX protein SKI PF01202.22 CDI83556.1 - 0.065 13.4 2.8 0.12 12.5 2.8 1.4 1 0 0 1 1 1 0 Shikimate kinase Peptidase_S49_N PF08496.10 CDI83556.1 - 0.075 13.1 6.6 0.16 12.0 6.6 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Connexin PF00029.19 CDI83556.1 - 0.078 12.7 0.5 0.1 12.3 0.5 1.2 1 0 0 1 1 1 0 Connexin TERB2 PF15101.6 CDI83556.1 - 0.34 10.9 10.1 0.74 9.8 10.1 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CLN3 PF02487.17 CDI83556.1 - 0.83 8.6 6.2 1.7 7.6 6.2 1.4 1 0 0 1 1 1 0 CLN3 protein eIF-3_zeta PF05091.12 CDI83556.1 - 2.2 7.1 11.8 2.9 6.7 11.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI83556.1 - 4.2 6.0 15.5 0.16 10.7 8.9 1.7 2 0 0 2 2 2 0 Presenilin FAM60A PF15396.6 CDI83556.1 - 4.5 7.2 6.9 1.3 9.0 4.1 1.5 2 0 0 2 2 2 0 Protein Family FAM60A PspA_IM30 PF04012.12 CDI83572.1 - 4.9e-05 23.0 15.2 4.9e-05 23.0 15.2 2.2 2 0 0 2 2 2 1 PspA/IM30 family ATP-synt_D PF01813.17 CDI83572.1 - 0.0014 18.5 22.7 0.016 15.1 2.1 3.1 2 1 1 3 3 3 2 ATP synthase subunit D DUF4763 PF15960.5 CDI83572.1 - 0.0057 16.0 13.7 0.0057 16.0 13.7 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4763) Peripla_BP_3 PF13377.6 CDI83572.1 - 0.076 13.3 0.1 0.17 12.2 0.1 1.6 1 0 0 1 1 1 0 Periplasmic binding protein-like domain Spc7 PF08317.11 CDI83572.1 - 0.2 10.5 41.0 0.35 9.7 22.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Auts2 PF15336.6 CDI83572.1 - 0.32 11.1 2.3 0.59 10.2 2.3 1.5 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein ATG16 PF08614.11 CDI83572.1 - 0.43 10.8 41.8 7.1 6.8 18.7 2.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4497 PF14924.6 CDI83572.1 - 0.54 10.7 2.2 1.3 9.6 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4497) Ntox28 PF15605.6 CDI83572.1 - 0.83 9.9 12.5 0.073 13.3 5.1 2.6 2 1 0 3 3 3 0 Bacterial toxin 28 GAS PF13851.6 CDI83572.1 - 0.87 8.9 38.4 0.63 9.4 13.8 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 CDI83572.1 - 0.9 9.6 41.5 3.5 7.7 21.0 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.21 CDI83572.1 - 1.1 8.8 36.0 2.8 7.4 36.0 1.6 1 1 0 1 1 1 0 Intermediate filament protein DUF4407 PF14362.6 CDI83572.1 - 1.2 8.5 32.4 0.12 11.7 10.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) PCYCGC PF13798.6 CDI83572.1 - 1.2 8.9 3.5 8.2 6.2 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function with PCYCGC motif TMF_DNA_bd PF12329.8 CDI83572.1 - 1.6 8.8 46.2 0.49 10.4 7.4 4.6 2 1 2 4 4 3 0 TATA element modulatory factor 1 DNA binding Baculo_PEP_C PF04513.12 CDI83572.1 - 3 7.9 10.6 5.5 7.0 0.7 2.8 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HOOK PF05622.12 CDI83572.1 - 4 5.5 37.5 0.42 8.7 26.6 2.0 1 1 1 2 2 2 0 HOOK protein HIP1_clath_bdg PF16515.5 CDI83572.1 - 4.2 8.0 38.2 0.83 10.3 9.4 3.6 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 BST2 PF16716.5 CDI83572.1 - 7.4 7.2 39.4 0.1 13.2 14.8 3.9 1 1 2 4 4 4 0 Bone marrow stromal antigen 2 LCIB_C_CA PF18599.1 CDI83572.1 - 7.9 5.7 11.3 0.59 9.4 4.4 2.0 1 1 1 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases TFIIA PF03153.13 CDI83584.1 - 2.1e-06 28.0 37.7 3.1e-06 27.5 37.7 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 CDI83584.1 - 0.00012 21.9 21.8 0.00021 21.1 21.8 1.4 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein PAT1 PF09770.9 CDI83584.1 - 0.61 8.3 27.8 0.7 8.1 27.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PepSY_TM PF03929.16 CDI83584.1 - 1 9.0 3.4 1.6 8.3 3.4 1.5 1 0 0 1 1 1 0 PepSY-associated TM region DUF5523 PF17661.1 CDI83584.1 - 1.3 8.7 29.3 0.82 9.3 7.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) DUF3112 PF11309.8 CDI83584.1 - 1.4 8.3 5.4 2.5 7.5 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) BUD22 PF09073.10 CDI83584.1 - 1.6 8.0 37.4 0.076 12.3 18.7 2.0 1 1 1 2 2 2 0 BUD22 Peptidase_S15 PF02129.18 CDI83584.1 - 1.8 8.1 11.0 3.1 7.3 11.0 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF3474 PF11960.8 CDI83584.1 - 3.9 7.7 9.4 5 7.3 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3474) RPA43_OB PF17875.1 CDI83584.1 - 7.6 7.2 14.9 10 6.8 6.2 2.6 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I DUF4770 PF15994.5 CDI83584.1 - 9 6.5 17.1 1.8 8.8 12.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Scs3p PF10261.9 CDI83584.1 - 9.9 5.6 5.7 18 4.8 5.7 1.3 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Pkinase PF00069.25 CDI83591.1 - 1.6e-30 106.4 0.1 9.5e-18 64.5 0.0 3.6 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83591.1 - 2.9e-09 36.6 0.0 0.0034 16.7 0.0 3.7 3 0 0 3 3 3 2 Protein tyrosine kinase SUIM_assoc PF16619.5 CDI83591.1 - 0.01 15.9 1.8 0.01 15.9 1.8 6.3 5 1 0 5 5 5 2 Unstructured region C-term to UIM in Ataxin3 DUF4746 PF15928.5 CDI83591.1 - 0.9 8.9 13.1 0.044 13.2 6.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF5094 PF17015.5 CDI83591.1 - 1.1 9.4 5.5 2.7 8.1 0.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5094) NARP1 PF12569.8 CDI83591.1 - 1.4 7.8 15.2 4.1 6.2 15.2 1.8 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Pox_Ag35 PF03286.14 CDI83591.1 - 2.2 8.0 7.2 5.2 6.8 7.2 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein AF-4 PF05110.13 CDI83612.1 - 0.11 10.6 47.2 0.14 10.3 47.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein RskA PF10099.9 CDI83625.1 - 0.00053 20.3 26.8 0.00053 20.3 26.8 2.3 1 1 1 2 2 2 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI83625.1 - 0.00078 19.6 37.2 0.001 19.1 37.2 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 CDI83625.1 - 0.0044 15.9 19.2 0.0045 15.9 19.2 1.2 1 0 0 1 1 1 1 Golgi-body localisation protein domain CDC45 PF02724.14 CDI83625.1 - 0.026 12.9 19.8 0.033 12.5 19.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF908 PF06012.12 CDI83625.1 - 0.046 13.1 28.2 0.063 12.7 28.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Plasmodium_Vir PF05795.11 CDI83625.1 - 0.055 12.9 15.5 0.074 12.5 15.5 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SLC12 PF03522.15 CDI83625.1 - 0.18 10.8 17.9 0.21 10.6 17.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Peptidase_S64 PF08192.11 CDI83625.1 - 0.24 9.9 26.5 0.25 9.8 26.5 1.2 1 0 0 1 1 1 0 Peptidase family S64 CD20 PF04103.15 CDI83625.1 - 0.43 10.7 6.3 0.11 12.5 0.3 2.2 2 0 0 2 2 2 0 CD20-like family DUF4647 PF15504.6 CDI83625.1 - 0.44 9.6 20.1 0.63 9.1 20.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Rrn6 PF10214.9 CDI83625.1 - 0.46 8.9 34.5 0.53 8.7 34.5 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor GREB1 PF15782.5 CDI83625.1 - 0.89 6.6 32.8 1 6.4 32.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PA26 PF04636.13 CDI83625.1 - 1.4 7.7 14.0 1.7 7.4 14.0 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) O-antigen_lig PF13425.6 CDI83625.1 - 1.6 7.4 3.7 1.8 7.3 3.7 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DivIC PF04977.15 CDI83625.1 - 1.7 8.5 12.7 3.6 7.4 12.7 1.6 1 0 0 1 1 1 0 Septum formation initiator DDRGK PF09756.9 CDI83625.1 - 2.5 7.7 19.9 3.9 7.0 19.9 1.3 1 0 0 1 1 1 0 DDRGK domain Utp14 PF04615.13 CDI83625.1 - 2.8 6.4 30.6 4.6 5.7 30.6 1.3 1 0 0 1 1 1 0 Utp14 protein PAT1 PF09770.9 CDI83625.1 - 2.9 6.0 26.5 3.7 5.7 26.5 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 eIF-3_zeta PF05091.12 CDI83625.1 - 3 6.7 19.1 3.5 6.5 19.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Dicty_REP PF05086.12 CDI83625.1 - 3.6 5.4 13.4 4.1 5.3 13.4 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Membralin PF09746.9 CDI83625.1 - 7.9 5.4 14.7 12 4.9 14.7 1.2 1 0 0 1 1 1 0 Tumour-associated protein LMBR1 PF04791.16 CDI83625.1 - 9.3 5.0 8.1 12 4.6 8.1 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein ALMT PF11744.8 CDI83625.1 - 9.6 4.9 19.8 13 4.5 19.8 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter PA26 PF04636.13 CDI83626.1 - 0.15 11.0 18.1 0.21 10.5 18.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PAT1 PF09770.9 CDI83626.1 - 0.71 8.1 47.5 0.84 7.8 47.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SOBP PF15279.6 CDI83626.1 - 1.7 9.2 36.2 2.1 8.9 36.2 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein FlxA PF14282.6 CDI83641.1 - 0.14 12.1 27.4 2.8 8.0 23.9 2.1 2 0 0 2 2 2 0 FlxA-like protein CDH1_2_SANT_HL1 PF18375.1 CDI83641.1 - 0.21 12.3 4.9 0.39 11.4 4.9 1.4 1 0 0 1 1 1 0 CDH1/2 SANT-Helical linker 1 Spt20 PF12090.8 CDI83641.1 - 0.49 10.0 12.9 0.54 9.8 12.9 1.2 1 0 0 1 1 1 0 Spt20 family Phage_GPO PF05929.11 CDI83641.1 - 0.49 10.0 12.3 0.61 9.7 12.3 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Roughex PF06020.11 CDI83641.1 - 0.55 9.3 5.0 0.61 9.1 5.0 1.1 1 0 0 1 1 1 0 Drosophila roughex protein UPF0240 PF06784.11 CDI83641.1 - 0.9 9.6 10.0 0.84 9.7 9.1 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0240) V_ATPase_I PF01496.19 CDI83641.1 - 0.91 7.4 7.3 0.83 7.5 7.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ndc1_Nup PF09531.10 CDI83641.1 - 1.3 7.6 10.5 1.4 7.5 10.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DDHD PF02862.17 CDI83641.1 - 2.3 8.3 8.8 2.4 8.2 8.8 1.1 1 0 0 1 1 1 0 DDHD domain DUF3807 PF12720.7 CDI83641.1 - 3.8 7.7 13.7 4.6 7.5 13.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) TFIIA PF03153.13 CDI83641.1 - 6 6.8 18.7 7.1 6.5 18.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF719 PF05334.13 CDI83672.1 - 0.0017 18.6 1.9 0.0017 18.6 1.9 4.8 4 0 0 4 4 3 1 Protein of unknown function (DUF719) O-antigen_lig PF13425.6 CDI83672.1 - 0.0075 15.1 0.9 0.0075 15.1 0.9 2.7 2 1 1 3 3 3 1 O-antigen ligase like membrane protein Band_3_cyto PF07565.13 CDI83672.1 - 0.017 14.9 33.5 0.15 11.8 6.4 3.4 3 0 0 3 3 3 0 Band 3 cytoplasmic domain MecA PF05389.12 CDI83672.1 - 0.043 13.4 22.6 1.1 8.8 0.2 3.4 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) ESM4 PF15952.5 CDI83672.1 - 1.1 9.6 47.0 0.51 10.8 18.4 3.3 3 0 0 3 3 3 0 Enhancer of split M4 family DUF4471 PF14740.6 CDI83672.1 - 1.5 8.0 23.6 6.4 5.9 1.7 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4471) PRC2_HTH_1 PF18118.1 CDI83672.1 - 2.1 9.2 25.1 9.4 7.1 0.2 4.0 3 0 0 3 3 3 0 Polycomb repressive complex 2 tri-helical domain Peptidase_S49_N PF08496.10 CDI83672.1 - 2.3 8.3 44.9 0.72 9.9 1.9 4.4 4 0 0 4 4 4 0 Peptidase family S49 N-terminal Afi1 PF07792.12 CDI83672.1 - 2.4 8.6 30.6 1.7 9.2 1.7 3.4 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking TERB2 PF15101.6 CDI83672.1 - 3.3 7.7 55.2 0.37 10.8 5.8 3.8 4 0 0 4 4 4 0 Telomere-associated protein TERB2 eIF-3_zeta PF05091.12 CDI83672.1 - 3.5 6.5 40.6 0.48 9.3 11.6 3.2 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Caldesmon PF02029.15 CDI83672.1 - 6.7 5.3 44.0 0.72 8.5 28.1 2.4 2 0 0 2 2 2 0 Caldesmon DUF4820 PF16091.5 CDI83672.1 - 6.8 6.0 33.5 5.8 6.2 7.3 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4820) Coilin_N PF15862.5 CDI83686.1 - 0.016 15.0 7.2 11 5.8 0.0 3.5 3 1 0 3 3 3 0 Coilin N-terminus F-protein PF00469.20 CDI83686.1 - 3.7 7.1 8.6 0.62 9.6 0.9 2.5 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef Leo1 PF04004.13 CDI83692.1 - 3.9e-05 23.6 0.2 3.9e-05 23.6 0.2 2.0 2 2 0 2 2 2 1 Leo1-like protein Serpulina_VSP PF05540.11 CDI83692.1 - 0.16 11.0 0.2 0.31 10.1 0.2 1.4 1 0 0 1 1 1 0 Serpulina hyodysenteriae variable surface protein DUF2722 PF10846.8 CDI83692.1 - 1.7 7.5 11.4 0.1 11.5 5.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF572 PF04502.13 CDI83700.1 - 9.4 5.7 42.0 0.084 12.5 24.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) SR-25 PF10500.9 CDI83705.1 - 5e-07 29.6 26.0 5.8e-07 29.3 26.0 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein RR_TM4-6 PF06459.12 CDI83705.1 - 0.0056 16.5 7.6 0.0066 16.3 7.6 1.2 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Nop53 PF07767.11 CDI83705.1 - 0.0074 15.7 11.1 0.0084 15.5 11.1 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DUF5308 PF17233.2 CDI83705.1 - 0.0089 16.3 8.8 0.012 15.8 8.8 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5308) Nop14 PF04147.12 CDI83705.1 - 0.022 13.0 11.6 0.027 12.7 11.6 1.0 1 0 0 1 1 1 0 Nop14-like family MID_MedPIWI PF18296.1 CDI83705.1 - 0.034 14.0 13.3 0.038 13.8 13.3 1.0 1 0 0 1 1 1 0 MID domain of medPIWI Med3 PF11593.8 CDI83705.1 - 0.037 13.2 15.7 0.04 13.1 15.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Connexin PF00029.19 CDI83705.1 - 0.037 13.8 5.4 0.041 13.6 5.4 1.1 1 0 0 1 1 1 0 Connexin Suf PF05843.14 CDI83705.1 - 0.039 13.9 14.7 0.046 13.7 14.7 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 CDI83705.1 - 0.04 13.9 23.0 0.043 13.8 23.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Velvet PF11754.8 CDI83705.1 - 0.049 13.6 16.1 0.053 13.4 16.1 1.0 1 0 0 1 1 1 0 Velvet factor CSG2 PF16965.5 CDI83705.1 - 0.049 12.6 6.0 0.049 12.6 6.0 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator PPL5 PF18168.1 CDI83705.1 - 0.053 12.8 6.3 0.06 12.6 6.3 1.0 1 0 0 1 1 1 0 Prim-pol family 5 CCSAP PF15748.5 CDI83705.1 - 0.058 13.6 18.1 0.072 13.3 18.1 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PIP5K PF01504.18 CDI83705.1 - 0.064 12.5 8.5 0.073 12.3 8.5 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Pex14_N PF04695.13 CDI83705.1 - 0.067 13.8 16.7 0.08 13.6 16.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2370 PF10176.9 CDI83705.1 - 0.074 12.7 3.5 0.096 12.3 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF913 PF06025.12 CDI83705.1 - 0.093 11.7 8.9 0.1 11.6 8.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CCDC106 PF15794.5 CDI83705.1 - 0.096 12.4 19.3 0.12 12.1 19.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 MCM_bind PF09739.9 CDI83705.1 - 0.15 10.4 10.0 0.17 10.3 10.0 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor NAM-associated PF14303.6 CDI83705.1 - 0.16 12.7 16.6 0.2 12.3 16.6 1.1 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain NARP1 PF12569.8 CDI83705.1 - 0.17 10.8 9.6 0.19 10.6 9.6 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF2828 PF11443.8 CDI83705.1 - 0.19 9.8 7.9 0.2 9.7 7.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Spem1 PF15670.5 CDI83705.1 - 0.2 11.2 12.5 0.22 11.1 12.5 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 EOS1 PF12326.8 CDI83705.1 - 0.21 11.5 6.6 0.26 11.2 6.6 1.3 1 0 0 1 1 1 0 N-glycosylation protein Bul1_N PF04425.12 CDI83705.1 - 0.23 10.2 11.2 0.26 10.0 11.2 1.0 1 0 0 1 1 1 0 Bul1 N terminus CobT PF06213.12 CDI83705.1 - 0.24 10.7 18.3 0.28 10.5 18.3 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT V_ATPase_I PF01496.19 CDI83705.1 - 0.25 9.2 9.9 0.26 9.2 9.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3827 PF12877.7 CDI83705.1 - 0.26 9.6 17.0 0.29 9.5 17.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) TCP PF03634.13 CDI83705.1 - 0.28 11.7 17.3 0.34 11.4 17.3 1.1 1 0 0 1 1 1 0 TCP family transcription factor Serinc PF03348.15 CDI83705.1 - 0.28 10.1 7.2 0.31 9.9 7.2 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF572 PF04502.13 CDI83705.1 - 0.3 10.7 13.3 0.34 10.5 13.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Zip PF02535.22 CDI83705.1 - 0.31 10.2 9.1 0.34 10.1 9.1 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4820 PF16091.5 CDI83705.1 - 0.32 10.3 10.0 0.41 10.0 10.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF5427 PF10310.9 CDI83705.1 - 0.35 9.8 16.7 0.39 9.6 16.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SpoIIP PF07454.11 CDI83705.1 - 0.36 10.2 10.2 0.4 10.1 10.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PA26 PF04636.13 CDI83705.1 - 0.38 9.6 8.4 0.42 9.5 8.4 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4603 PF15376.6 CDI83705.1 - 0.39 8.0 17.3 0.45 7.8 17.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) TPX2 PF06886.11 CDI83705.1 - 0.42 10.9 15.0 0.54 10.5 15.0 1.1 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) CLN3 PF02487.17 CDI83705.1 - 0.43 9.6 6.6 0.45 9.5 6.6 1.0 1 0 0 1 1 1 0 CLN3 protein Coilin_N PF15862.5 CDI83705.1 - 0.47 10.3 21.6 0.58 10.0 21.6 1.1 1 0 0 1 1 1 0 Coilin N-terminus CPSF100_C PF13299.6 CDI83705.1 - 0.52 10.5 8.3 0.72 10.0 8.3 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4228 PF14009.6 CDI83705.1 - 0.58 10.5 11.4 0.7 10.3 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) MFMR_assoc PF16596.5 CDI83705.1 - 0.63 10.5 21.2 0.71 10.3 21.2 1.0 1 0 0 1 1 1 0 Disordered region downstream of MFMR FancD2 PF14631.6 CDI83705.1 - 0.68 7.2 8.4 0.77 7.1 8.4 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DUF5521 PF17659.1 CDI83705.1 - 0.69 7.7 9.8 0.74 7.6 9.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5521) CDC45 PF02724.14 CDI83705.1 - 0.73 8.1 15.6 0.86 7.8 15.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Ureide_permease PF07168.11 CDI83705.1 - 0.76 8.5 5.5 0.84 8.3 5.5 1.0 1 0 0 1 1 1 0 Ureide permease FAM199X PF15814.5 CDI83705.1 - 0.78 8.7 18.5 1 8.4 18.5 1.1 1 0 0 1 1 1 0 Protein family FAM199X eIF-3_zeta PF05091.12 CDI83705.1 - 0.81 8.6 14.8 0.87 8.5 14.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF1980 PF09323.10 CDI83705.1 - 0.85 9.5 7.8 1 9.2 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Spt20 PF12090.8 CDI83705.1 - 0.85 9.2 30.9 1.1 8.8 30.9 1.2 1 0 0 1 1 1 0 Spt20 family Tim54 PF11711.8 CDI83705.1 - 0.97 8.2 9.5 1.1 8.0 9.5 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AUX_IAA PF02309.16 CDI83705.1 - 1 9.2 9.6 1.2 8.9 9.6 1.0 1 0 0 1 1 1 0 AUX/IAA family DUF515 PF04415.12 CDI83705.1 - 1.1 7.5 22.5 1.3 7.4 22.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Roughex PF06020.11 CDI83705.1 - 1.2 8.2 9.5 1.3 8.1 9.5 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Baculo_PP31 PF05311.11 CDI83705.1 - 1.2 8.6 13.8 1.4 8.4 13.8 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Kei1 PF08552.11 CDI83705.1 - 1.2 9.0 11.0 1.6 8.6 11.0 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4614 PF15391.6 CDI83705.1 - 1.4 8.8 26.0 1.8 8.5 26.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Folliculin PF11704.8 CDI83705.1 - 1.6 8.6 10.8 1.8 8.4 10.8 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF2126 PF09899.9 CDI83705.1 - 1.7 6.6 6.4 1.8 6.5 6.4 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) F-protein PF00469.20 CDI83705.1 - 1.9 8.0 11.3 2.2 7.8 11.3 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Neur_chan_memb PF02932.16 CDI83705.1 - 2.1 8.3 10.5 2.4 8.1 10.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3292 PF11696.8 CDI83705.1 - 2.4 6.4 7.9 2.8 6.2 7.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) CCDC53 PF10152.9 CDI83705.1 - 2.6 8.5 11.9 3.5 8.0 11.9 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Rtf2 PF04641.12 CDI83705.1 - 2.6 7.3 13.9 3.1 7.1 13.9 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DDHD PF02862.17 CDI83705.1 - 3.8 7.6 13.7 5.7 7.0 13.7 1.2 1 0 0 1 1 1 0 DDHD domain DUF1682 PF07946.14 CDI83705.1 - 3.9 6.6 11.1 4.7 6.3 11.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Cellulose_synt PF03552.14 CDI83705.1 - 3.9 5.8 4.8 4.2 5.7 4.8 1.0 1 0 0 1 1 1 0 Cellulose synthase Ndc1_Nup PF09531.10 CDI83705.1 - 4 6.0 16.9 4.6 5.8 16.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SID-1_RNA_chan PF13965.6 CDI83705.1 - 4.2 5.7 6.1 4.4 5.6 6.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Rubella_Capsid PF05750.11 CDI83705.1 - 4.3 6.8 7.5 5 6.7 7.5 1.0 1 0 0 1 1 1 0 Rubella capsid protein Smg8_Smg9 PF10220.9 CDI83705.1 - 4.7 5.4 15.2 5.3 5.2 15.2 1.0 1 0 0 1 1 1 0 Smg8_Smg9 EFTUD2 PF16004.5 CDI83705.1 - 5 7.7 14.4 7.5 7.2 14.4 1.3 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus SOBP PF15279.6 CDI83705.1 - 5.4 7.5 17.3 6.4 7.3 17.3 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Band_3_cyto PF07565.13 CDI83705.1 - 6 6.6 13.3 7.1 6.3 13.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Membralin PF09746.9 CDI83705.1 - 6.3 5.7 7.4 7 5.6 7.4 1.0 1 0 0 1 1 1 0 Tumour-associated protein Peptidase_S64 PF08192.11 CDI83705.1 - 6.8 5.1 16.8 7.7 4.9 16.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 SLC12 PF03522.15 CDI83705.1 - 7 5.6 13.6 8 5.4 13.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 THRAP3_BCLAF1 PF15440.6 CDI83705.1 - 7.1 5.5 29.4 8.1 5.3 29.4 1.0 1 0 0 1 1 1 0 THRAP3/BCLAF1 family ALMT PF11744.8 CDI83705.1 - 7.8 5.2 10.7 8.9 5.0 10.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter GREB1 PF15782.5 CDI83705.1 - 9 3.3 16.6 10 3.1 16.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 CDI83705.1 - 9 4.9 21.9 11 4.7 21.9 1.0 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 CDI83705.1 - 9.8 5.6 10.3 12 5.4 10.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2967 PF11179.8 CDI83705.1 - 9.9 4.1 24.3 13 3.8 24.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Dapper PF15268.6 CDI83706.1 - 0.97 8.2 43.6 1.1 8.0 43.6 1.0 1 0 0 1 1 1 0 Dapper DUF5427 PF10310.9 CDI83706.1 - 3.3 6.6 35.3 4.9 6.0 35.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) RIFIN PF02009.16 CDI83707.1 - 0.022 14.7 22.1 0.027 14.4 22.1 1.1 1 0 0 1 1 1 0 Rifin Presenilin PF01080.17 CDI83707.1 - 0.33 9.7 30.3 0.39 9.4 30.3 1.1 1 0 0 1 1 1 0 Presenilin DUF572 PF04502.13 CDI83707.1 - 0.43 10.1 23.2 0.53 9.8 23.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) MID_MedPIWI PF18296.1 CDI83707.1 - 0.54 10.0 22.7 0.74 9.6 22.7 1.3 1 0 0 1 1 1 0 MID domain of medPIWI DUF3597 PF12200.8 CDI83707.1 - 0.55 10.8 22.4 0.061 13.9 5.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) eIF-3_zeta PF05091.12 CDI83707.1 - 0.93 8.4 30.9 1.3 7.9 30.9 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CcmF_C PF16327.5 CDI83707.1 - 1.5 8.0 6.4 1.9 7.7 6.4 1.1 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal Myc_N PF01056.18 CDI83707.1 - 2.1 8.2 18.4 2.6 7.9 18.4 1.0 1 0 0 1 1 1 0 Myc amino-terminal region Anoctamin PF04547.12 CDI83707.1 - 3.3 6.4 15.6 3.8 6.3 15.6 1.0 1 0 0 1 1 1 0 Calcium-activated chloride channel Band_3_cyto PF07565.13 CDI83707.1 - 3.8 7.2 27.8 4.6 7.0 27.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4746 PF15928.5 CDI83707.1 - 4.6 6.6 20.4 6.1 6.2 19.7 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4746) CCSAP PF15748.5 CDI83707.1 - 5.1 7.2 28.1 7.5 6.7 28.1 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SKA1 PF07160.12 CDI83707.1 - 5.4 6.8 32.2 6 6.6 32.2 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Smg8_Smg9 PF10220.9 CDI83707.1 - 7.3 4.8 26.3 8.3 4.6 26.3 1.0 1 0 0 1 1 1 0 Smg8_Smg9 FapA PF03961.13 CDI83707.1 - 7.6 5.0 20.4 8.9 4.8 20.4 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4776 PF16003.5 CDI83707.1 - 9 5.2 25.5 11 4.8 25.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) MRP-S31 PF15433.6 CDI83707.1 - 9.4 5.8 32.5 11 5.6 32.5 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 TSP_1 PF00090.19 CDI83742.1 - 6.8e-06 26.2 29.9 0.00071 19.8 4.0 5.5 4 0 0 4 4 4 2 Thrombospondin type 1 domain Aconitase PF00330.20 CDI83749.1 - 6.6e-169 562.8 0.0 8.3e-169 562.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CDI83749.1 - 1.1e-42 145.5 0.0 1.7e-42 144.8 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain Nsp1_C PF05064.13 CDI83755.1 - 1e-11 44.6 3.5 1e-11 44.6 3.5 1.9 2 1 0 2 2 2 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 CDI83755.1 - 9.7e-11 42.4 146.6 0.0014 19.5 30.0 6.9 1 1 3 4 4 4 1 Nucleoporin FG repeat region ABC_tran_CTD PF16326.5 CDI83755.1 - 0.67 10.2 5.1 0.39 11.0 0.2 2.7 1 1 1 3 3 3 0 ABC transporter C-terminal domain Baculo_PEP_C PF04513.12 CDI83755.1 - 1.5 8.9 5.8 0.78 9.8 2.8 1.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 CDI83755.1 - 1.8 8.6 8.8 8.2 6.5 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 CDI83755.1 - 2.3 8.4 6.6 2.6 8.2 3.6 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Pkinase PF00069.25 CDI83756.1 - 1.6e-32 112.9 0.0 1.9e-32 112.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83756.1 - 8.9e-24 84.2 0.0 1.1e-23 83.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI83756.1 - 9.8e-11 41.1 0.0 1.4e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDI83756.1 - 0.00056 19.9 0.0 0.018 15.0 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family ABC1 PF03109.16 CDI83756.1 - 0.015 15.5 0.0 0.036 14.2 0.0 1.6 1 1 0 1 1 1 0 ABC1 family Pox_ser-thr_kin PF05445.11 CDI83756.1 - 0.04 12.9 0.1 0.058 12.4 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 CDI83756.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDI83756.1 - 0.2 11.0 0.0 11 5.3 0.0 2.7 3 0 0 3 3 3 0 Kinase-like Asparaginase PF00710.20 CDI83756.1 - 0.21 11.1 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 Asparaginase, N-terminal Med11 PF10280.9 CDI83757.1 - 0.052 14.0 0.5 5.1 7.6 0.0 2.7 2 1 0 2 2 2 0 Mediator complex protein Etmic-2 PF06670.11 CDI83758.1 - 0.13 11.1 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Microneme protein Etmic-2 Dynamin_M PF01031.20 CDI83763.1 - 3.5e-71 239.8 0.0 5.6e-71 239.1 0.0 1.3 1 0 0 1 1 1 1 Dynamin central region GED PF02212.18 CDI83763.1 - 1e-30 105.7 3.5 1.6e-30 105.1 1.9 2.2 2 0 0 2 2 2 1 Dynamin GTPase effector domain T3SS_needle_E PF08988.10 CDI83763.1 - 0.12 12.5 2.2 0.95 9.7 0.1 2.5 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle CelTOS PF18659.1 CDI83763.1 - 0.31 11.5 2.5 19 5.7 0.1 2.5 2 0 0 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites Dynamin_N PF00350.23 CDI83764.1 - 1.6e-52 178.0 0.0 1.9e-52 177.7 0.0 1.0 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CDI83764.1 - 2.9e-07 30.6 0.0 6.1e-07 29.5 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.6 CDI83764.1 - 0.0028 17.5 0.0 0.0039 17.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDI83764.1 - 0.022 15.2 0.1 0.026 14.9 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 CDI83764.1 - 0.045 14.0 0.0 0.064 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 CDI83764.1 - 0.073 13.3 0.0 0.32 11.2 0.0 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 CDI83764.1 - 0.096 12.2 0.0 1.6 8.3 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B VirE PF05272.11 CDI83764.1 - 0.14 11.8 0.0 0.21 11.3 0.0 1.1 1 0 0 1 1 1 0 Virulence-associated protein E AAA_15 PF13175.6 CDI83764.1 - 0.23 11.1 0.0 0.27 10.9 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Amino_oxidase PF01593.24 CDI83765.1 - 2.9e-46 158.7 10.7 1.1e-38 133.7 0.1 3.5 4 0 0 4 4 4 2 Flavin containing amine oxidoreductase zf-CW PF07496.15 CDI83765.1 - 6.4e-38 128.5 38.6 6.1e-13 48.6 5.2 3.8 3 0 0 3 3 3 3 CW-type Zinc Finger NAD_binding_8 PF13450.6 CDI83765.1 - 1.6e-06 28.3 6.7 9.3e-05 22.6 6.7 3.2 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CDI83765.1 - 0.0022 17.3 0.2 0.0051 16.1 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDI83765.1 - 0.013 14.8 1.6 0.024 13.9 1.6 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDI83765.1 - 0.017 13.9 0.3 0.017 13.9 0.3 2.7 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 CDI83765.1 - 0.046 12.9 0.6 0.11 11.7 0.6 1.6 1 0 0 1 1 1 0 Thi4 family Integrase_H2C2 PF17921.1 CDI83776.1 - 2.6e-15 56.3 0.2 2.6e-15 56.3 0.2 2.4 3 0 0 3 3 3 1 Integrase zinc binding domain rve PF00665.26 CDI83776.1 - 2.3e-12 47.1 0.0 7.3e-12 45.5 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 CDI83776.1 - 0.003 17.8 0.0 0.0062 16.7 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 CDI83776.1 - 0.025 14.4 0.2 1.1 9.1 0.2 2.5 2 0 0 2 2 2 0 Integrase core domain RT_RNaseH_2 PF17919.1 CDI83777.1 - 2.3e-16 59.6 0.0 4e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI83777.1 - 3.5e-08 33.7 0.0 6.6e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDI83777.1 - 0.0054 16.3 0.1 0.1 12.1 0.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Folate_carrier PF01770.18 CDI83777.1 - 0.029 13.1 0.1 0.17 10.6 0.1 1.8 2 0 0 2 2 2 0 Reduced folate carrier DUF4913 PF16259.5 CDI83777.1 - 0.14 12.3 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4913) gag-asp_proteas PF13975.6 CDI83779.1 - 0.00015 22.2 0.0 0.00034 21.1 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDI83779.1 - 0.00046 20.8 0.4 0.0011 19.6 0.0 1.8 2 0 0 2 2 2 1 Aspartyl protease RVP_2 PF08284.11 CDI83779.1 - 0.027 14.2 0.0 0.044 13.5 0.0 1.2 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF1758 PF05585.12 CDI83779.1 - 0.19 11.5 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 Putative peptidase (DUF1758) zf-CCHC PF00098.23 CDI83779.1 - 6.9 6.9 9.8 0.12 12.5 0.8 2.3 2 0 0 2 2 2 0 Zinc knuckle Peptidase_C37 PF05416.12 CDI83781.1 - 0.28 9.7 6.9 0.37 9.3 6.9 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase Nop53 PF07767.11 CDI83781.1 - 0.31 10.4 15.2 0.36 10.2 15.2 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SR-25 PF10500.9 CDI83782.1 - 0.00078 19.1 28.7 0.00078 19.1 28.7 3.8 4 0 0 4 4 4 1 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI83782.1 - 0.0044 16.7 7.8 0.0044 16.7 7.8 4.8 2 1 2 4 4 4 1 Spt20 family Ribosomal_S24e PF01282.19 CDI83783.1 - 5.7e-25 87.1 0.0 1e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e AAA_25 PF13481.6 CDI83783.1 - 0.03 13.9 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain P120R PF08062.11 CDI83783.1 - 0.5 10.8 6.7 2 8.9 0.1 2.7 2 0 0 2 2 2 0 P120R (NUC006) repeat PHC2_SAM_assoc PF16616.5 CDI83783.1 - 0.52 11.1 3.5 0.79 10.5 3.5 1.3 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Ribosomal_L1 PF00687.21 CDI83784.1 - 3.7e-30 105.2 5.0 8.3e-24 84.5 0.9 2.0 1 1 1 2 2 2 2 Ribosomal protein L1p/L10e family DUF3824 PF12868.7 CDI83799.1 - 0.0036 18.0 23.6 0.0036 18.0 23.6 2.2 2 0 0 2 2 2 1 Domain of unknwon function (DUF3824) Macoilin PF09726.9 CDI83799.1 - 0.0038 15.8 20.3 0.0044 15.7 20.3 1.1 1 0 0 1 1 1 1 Macoilin family Draxin PF15550.6 CDI83799.1 - 0.17 11.7 17.9 0.21 11.4 17.9 1.0 1 0 0 1 1 1 0 Draxin GREB1 PF15782.5 CDI83799.1 - 0.19 8.8 30.8 0.21 8.7 30.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PAT1 PF09770.9 CDI83799.1 - 0.22 9.8 45.5 0.25 9.6 45.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SRP-alpha_N PF04086.13 CDI83799.1 - 0.47 10.3 29.5 0.62 9.9 29.5 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Dapper PF15268.6 CDI83799.1 - 0.5 9.2 32.3 0.59 8.9 32.3 1.1 1 0 0 1 1 1 0 Dapper Miff PF05644.11 CDI83799.1 - 0.52 9.9 23.2 0.61 9.6 23.2 1.1 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Peptidase_S64 PF08192.11 CDI83799.1 - 0.55 8.6 22.4 0.64 8.4 22.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 SLC12 PF03522.15 CDI83799.1 - 0.61 9.1 21.8 0.76 8.7 21.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SOBP PF15279.6 CDI83799.1 - 1.9 9.0 33.9 2.2 8.8 33.9 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein CDC45 PF02724.14 CDI83799.1 - 2.9 6.1 22.5 3.4 5.9 22.5 1.0 1 0 0 1 1 1 0 CDC45-like protein SPX PF03105.19 CDI83799.1 - 3.4 7.5 33.1 3.9 7.3 33.1 1.1 1 0 0 1 1 1 0 SPX domain PAP1 PF08601.10 CDI83799.1 - 3.8 7.1 31.9 4.4 6.9 31.9 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 SR-25 PF10500.9 CDI83799.1 - 6.1 6.4 43.2 5.2 6.6 24.5 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein MAP65_ASE1 PF03999.12 CDI83799.1 - 6.5 5.3 23.6 7.7 5.1 23.6 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DUF21 PF01595.20 CDI83843.1 - 0.0012 18.6 0.0 0.0018 18.0 0.0 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain Spt5_N PF11942.8 CDI83848.1 - 0.0089 17.0 21.5 0.0089 17.0 21.5 3.9 2 2 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal M_domain PF12938.7 CDI83848.1 - 0.28 11.0 10.1 0.41 10.4 10.1 1.2 1 0 0 1 1 1 0 M domain of GW182 PAS PF00989.25 CDI83848.1 - 0.37 10.8 5.6 0.51 10.4 1.0 2.3 2 0 0 2 2 2 0 PAS fold Spt20 PF12090.8 CDI83848.1 - 0.49 10.0 25.2 0.09 12.4 4.4 2.1 2 0 0 2 2 2 0 Spt20 family CCSAP PF15748.5 CDI83848.1 - 0.65 10.1 29.9 0.91 9.6 29.9 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Med3 PF11593.8 CDI83848.1 - 3.5 6.7 8.2 5.7 6.0 8.2 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF740 PF05340.12 CDI83848.1 - 6.7 5.3 26.7 8.9 4.9 26.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) SOBP PF15279.6 CDI83848.1 - 8.3 6.9 9.8 13 6.3 9.8 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Sec7_N PF12783.7 CDI83885.1 - 2.9e-09 37.0 8.6 2.9e-09 37.0 8.6 2.8 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal BUD22 PF09073.10 CDI83885.1 - 0.00019 20.9 1.8 0.00019 20.9 1.8 13.0 8 4 3 11 11 11 2 BUD22 Spt20 PF12090.8 CDI83885.1 - 0.0031 17.1 8.2 0.0031 17.1 8.2 18.4 14 5 4 18 18 18 6 Spt20 family Arv1 PF04161.13 CDI83889.1 - 1.3e-17 64.7 1.1 1.3e-17 64.7 1.1 3.8 4 1 0 4 4 4 2 Arv1-like family BatD PF13584.6 CDI83889.1 - 0.00042 19.3 6.4 0.00042 19.3 6.4 5.3 2 1 3 6 6 6 2 Oxygen tolerance BSMAP PF12280.8 CDI83889.1 - 0.00051 20.3 2.6 0.00051 20.3 2.6 4.4 3 1 1 5 5 5 1 Brain specific membrane anchored protein TLC PF03219.14 CDI83889.1 - 0.057 12.1 0.0 0.1 11.3 0.0 1.4 1 0 0 1 1 1 0 TLC ATP/ADP transporter Nudix_N_2 PF14803.6 CDI83889.1 - 0.21 11.5 1.5 0.66 10.0 1.5 1.8 1 0 0 1 1 1 0 Nudix N-terminal DUF572 PF04502.13 CDI83889.1 - 3.7 7.1 51.7 0.047 13.3 19.5 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF572) TFIIF_beta PF02270.15 CDI83933.1 - 0.0019 18.3 0.2 0.0026 17.8 0.2 1.2 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain THOC7 PF05615.13 CDI83933.1 - 0.014 15.7 0.7 0.016 15.5 0.7 1.0 1 0 0 1 1 1 0 Tho complex subunit 7 RPA_C PF08784.11 CDI83933.1 - 0.037 14.7 0.4 0.16 12.7 0.1 1.8 1 1 1 2 2 2 0 Replication protein A C terminal DUF572 PF04502.13 CDI83939.1 - 2.5 7.6 46.9 3.3 7.2 46.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Nop14 PF04147.12 CDI83939.1 - 2.9 6.0 39.0 3.9 5.6 39.0 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4813 PF16072.5 CDI83939.1 - 3.6 7.2 16.0 4.9 6.7 16.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) BUD22 PF09073.10 CDI83939.1 - 4.1 6.6 55.7 1 8.6 44.7 2.0 2 0 0 2 2 2 0 BUD22 RskA PF10099.9 CDI83960.1 - 0.0019 18.5 18.4 0.0019 18.5 18.4 5.3 1 1 3 4 4 4 1 Anti-sigma-K factor rskA LMBR1 PF04791.16 CDI83960.1 - 0.004 16.1 17.3 0.0052 15.8 17.3 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein CDC45 PF02724.14 CDI83960.1 - 0.055 11.8 38.1 0.075 11.3 38.1 1.1 1 0 0 1 1 1 0 CDC45-like protein TrbL PF04610.14 CDI83960.1 - 0.83 9.4 8.1 1.2 8.9 8.1 1.3 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein Hid1 PF12722.7 CDI83960.1 - 7.5 4.5 44.1 12 3.9 44.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2722 PF10846.8 CDI83993.1 - 7.5e-05 21.9 0.4 7.5e-05 21.9 0.4 9.3 9 2 0 9 9 9 3 Protein of unknown function (DUF2722) Transp_cyt_pur PF02133.15 CDI83993.1 - 0.011 14.5 1.9 0.023 13.5 1.9 1.4 1 0 0 1 1 1 0 Permease for cytosine/purines, uracil, thiamine, allantoin SARAF PF06682.12 CDI83993.1 - 4 7.0 0.0 4 7.0 0.0 8.5 5 2 2 8 8 8 0 SOCE-associated regulatory factor of calcium homoeostasis RskA PF10099.9 CDI83994.1 - 8.2e-06 26.2 7.6 8.2e-06 26.2 7.6 6.3 2 2 2 4 4 4 2 Anti-sigma-K factor rskA DUF4401 PF14351.6 CDI83994.1 - 1.8 7.8 9.8 0.18 11.1 3.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4401) Prothymosin PF03247.14 CDI83995.1 - 0.24 11.9 19.0 0.17 12.4 9.3 2.1 2 0 0 2 2 2 0 Prothymosin/parathymosin family Peptidase_C37 PF05416.12 CDI83995.1 - 0.8 8.2 12.1 0.96 7.9 12.1 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase Myc_N PF01056.18 CDI83995.1 - 2 8.2 19.1 2.5 7.9 19.1 1.0 1 0 0 1 1 1 0 Myc amino-terminal region RPN2_C PF18004.1 CDI83995.1 - 4.4 7.2 26.3 2.7 7.9 4.7 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Nckap1 PF09735.9 CDI83995.1 - 6 4.7 15.1 8.8 4.1 15.1 1.3 1 1 0 1 1 1 0 Membrane-associated apoptosis protein Peroxin-3 PF04882.12 CDI83995.1 - 9.1 5.1 26.0 12 4.8 26.0 1.1 1 0 0 1 1 1 0 Peroxin-3 RskA PF10099.9 CDI84000.1 - 0.14 12.5 31.3 1.4e+02 2.7 31.3 2.2 1 1 0 1 1 1 0 Anti-sigma-K factor rskA SPX PF03105.19 CDI84000.1 - 1.8 8.4 11.7 2.3 8.1 11.7 1.1 1 0 0 1 1 1 0 SPX domain DUF2828 PF11443.8 CDI84005.1 - 0.016 13.3 31.1 0.029 12.5 17.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) N6_N4_Mtase PF01555.18 CDI84005.1 - 0.023 14.4 0.0 0.12 12.1 0.0 2.2 1 1 0 1 1 1 0 DNA methylase E1-N PF14463.6 CDI84005.1 - 0.055 13.3 0.7 0.055 13.3 0.7 4.2 3 1 1 4 4 4 0 E1 N-terminal domain SpoIIP PF07454.11 CDI84005.1 - 0.6 9.5 36.1 0.024 14.1 18.5 3.3 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) V_ATPase_I PF01496.19 CDI84005.1 - 1.4 6.8 36.0 0.48 8.3 23.2 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 CDI84005.1 - 2.7 7.7 29.4 0.47 10.2 16.9 3.0 3 0 0 3 3 3 0 Connexin FPN1 PF06963.12 CDI84005.1 - 4.2 5.8 26.1 1.2 7.6 0.5 3.4 2 1 0 2 2 2 0 Ferroportin1 (FPN1) DUF5134 PF17197.4 CDI84005.1 - 4.2 7.2 28.6 4.3 7.2 6.6 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5134) PAS_5 PF07310.13 CDI84022.1 - 1.9 8.3 7.5 5 6.9 0.1 2.5 3 0 0 3 3 3 0 PAS domain SART-1 PF03343.13 CDI84039.1 - 0.0018 16.9 10.2 0.0018 16.9 10.2 2.1 2 0 0 2 2 2 2 SART-1 family RskA PF10099.9 CDI84039.1 - 0.0099 16.2 23.5 0.0099 16.2 23.5 4.5 1 1 2 3 3 3 1 Anti-sigma-K factor rskA DUF2052 PF09747.9 CDI84039.1 - 0.018 15.2 24.3 0.24 11.5 14.3 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Nop53 PF07767.11 CDI84039.1 - 0.091 12.1 26.2 0.27 10.6 13.3 2.2 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) GAGA_bind PF06217.12 CDI84039.1 - 0.15 12.3 19.2 0.12 12.7 9.6 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family Neur_chan_memb PF02932.16 CDI84039.1 - 0.97 9.4 29.9 0.63 10.1 15.0 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SR-25 PF10500.9 CDI84039.1 - 1 8.9 45.3 0.078 12.6 3.0 3.5 3 1 0 3 3 3 0 Nuclear RNA-splicing-associated protein Use1 PF09753.9 CDI84039.1 - 3.3 7.4 26.0 1.2 8.8 13.8 2.3 2 0 0 2 2 2 0 Membrane fusion protein Use1 eIF-3_zeta PF05091.12 CDI84039.1 - 5.1 6.0 34.8 0.78 8.7 17.4 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PPL5 PF18168.1 CDI84039.1 - 7.4 5.8 22.2 1.4 8.1 2.9 2.4 2 0 0 2 2 2 0 Prim-pol family 5 DUF5421 PF17458.2 CDI84046.1 - 0.00011 21.7 2.2 0.00011 21.7 2.2 6.6 6 1 0 6 6 6 1 Family of unknown function (DUF5421) AAA_5 PF07728.14 CDI84057.1 - 2e-67 225.4 0.0 1.2e-20 73.9 0.0 8.3 7 1 1 8 8 8 7 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 CDI84057.1 - 7.3e-27 93.7 2.2 2.1e-12 47.1 0.0 3.4 3 0 0 3 3 2 2 Midasin AAA lid domain AAA_lid_5 PF17865.1 CDI84057.1 - 5e-20 71.6 0.0 1.4e-19 70.1 0.0 1.9 1 0 0 1 1 1 1 Midasin AAA lid domain AAA PF00004.29 CDI84057.1 - 1.5e-10 41.6 0.0 0.018 15.5 0.0 4.5 3 0 0 3 3 3 3 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDI84057.1 - 3.5e-09 36.4 0.0 0.032 13.8 0.0 3.6 3 0 0 3 3 3 3 P-loop containing dynein motor region AAA_3 PF07726.11 CDI84057.1 - 1.1e-08 35.0 0.0 8.9e-05 22.4 0.0 4.4 5 0 0 5 5 4 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 CDI84057.1 - 1.9e-08 34.3 0.5 0.29 11.1 0.1 3.7 3 0 0 3 3 3 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE Dynein_heavy PF03028.15 CDI84057.1 - 3.2e-07 30.4 0.0 1.3 9.1 0.0 4.8 4 0 0 4 4 3 3 Dynein heavy chain region D6 P-loop domain AAA_8 PF12780.7 CDI84057.1 - 1.2e-06 28.1 0.0 0.024 13.9 0.0 3.8 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 Phage_1_1 PF08200.11 CDI84057.1 - 3.5e-05 24.1 13.0 0.073 13.5 2.8 3.9 2 0 0 2 2 2 2 Bacteriophage 1.1 Protein AAA_6 PF12774.7 CDI84057.1 - 0.00034 19.7 0.0 0.43 9.5 0.0 3.8 4 1 0 4 4 3 1 Hydrolytic ATP binding site of dynein motor region RNA_helicase PF00910.22 CDI84057.1 - 0.00048 20.5 0.0 13 6.2 0.0 3.5 3 0 0 3 3 3 0 RNA helicase ABC_tran PF00005.27 CDI84057.1 - 0.00075 20.0 15.1 0.034 14.7 0.0 5.6 5 0 0 5 5 4 1 ABC transporter AAA_25 PF13481.6 CDI84057.1 - 0.00077 19.1 0.6 5.1 6.6 0.1 4.1 3 0 0 3 3 3 1 AAA domain DEAD PF00270.29 CDI84057.1 - 0.0039 17.0 0.0 0.41 10.4 0.0 3.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_29 PF13555.6 CDI84057.1 - 0.0042 16.8 0.1 8.6 6.2 0.0 3.6 3 0 0 3 3 3 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDI84057.1 - 0.0042 17.0 0.2 3.6 7.4 0.0 4.0 3 0 0 3 3 3 1 RsgA GTPase AAA_18 PF13238.6 CDI84057.1 - 0.0062 17.1 10.0 6.1 7.4 0.0 6.0 7 0 0 7 7 5 0 AAA domain AAA_22 PF13401.6 CDI84057.1 - 0.0079 16.5 19.4 0.046 14.0 0.0 5.8 6 0 0 6 6 3 2 AAA domain RuvB_N PF05496.12 CDI84057.1 - 0.013 15.3 0.0 12 5.6 0.0 4.1 4 0 0 4 4 4 0 Holliday junction DNA helicase RuvB P-loop domain Roc PF08477.13 CDI84057.1 - 0.013 15.7 0.1 14 5.9 0.0 3.9 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 CDI84057.1 - 0.018 15.4 0.1 0.018 15.4 0.1 8.7 5 3 3 8 8 5 0 AAA ATPase domain dNK PF01712.19 CDI84057.1 - 0.026 14.4 0.2 1.1 9.0 0.0 3.3 4 0 0 4 4 4 0 Deoxynucleoside kinase gag-asp_proteas PF13975.6 CDI84057.1 - 0.032 14.8 0.0 5.6 7.6 0.0 3.0 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Rad17 PF03215.15 CDI84057.1 - 0.045 13.7 0.1 0.9 9.4 0.0 2.9 3 0 0 3 3 3 0 Rad17 P-loop domain PduV-EutP PF10662.9 CDI84057.1 - 0.069 12.9 0.1 9.8 5.9 0.0 3.3 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation TIP49 PF06068.13 CDI84057.1 - 0.082 12.1 0.2 2 7.5 0.0 2.8 3 0 0 3 3 3 0 TIP49 P-loop domain AAA_23 PF13476.6 CDI84057.1 - 0.097 13.2 0.0 0.097 13.2 0.0 8.2 8 1 0 8 8 6 0 AAA domain ResIII PF04851.15 CDI84057.1 - 0.96 9.4 0.0 0.96 9.4 0.0 4.3 4 0 0 4 4 2 0 Type III restriction enzyme, res subunit Se-cys_synth_N PF12390.8 CDI84057.1 - 4.9 7.5 10.2 96 3.3 0.0 5.7 5 0 0 5 5 5 0 Selenocysteine synthase N terminal NDK PF00334.19 CDI84058.1 - 4.1e-17 62.5 0.0 1.9e-14 53.9 0.0 2.4 2 0 0 2 2 2 2 Nucleoside diphosphate kinase DUF1126 PF06565.12 CDI84058.1 - 3.4e-06 26.8 0.0 0.027 14.3 0.0 2.6 1 1 1 2 2 2 2 DUF1126 PH-like domain Rib PF08428.10 CDI84058.1 - 0.1 12.6 0.0 15 5.6 0.0 2.3 2 0 0 2 2 2 0 Rib/alpha-like repeat Fe-S_biosyn PF01521.20 CDI84059.1 - 8.8e-07 29.1 0.1 0.00047 20.3 0.0 2.6 2 1 0 2 2 2 2 Iron-sulphur cluster biosynthesis RskA PF10099.9 CDI84064.1 - 0.19 12.0 36.1 10 6.4 13.7 3.0 1 1 1 2 2 2 0 Anti-sigma-K factor rskA AF-4 PF05110.13 CDI84065.1 - 8.6e-06 24.2 49.0 1.1e-05 23.9 49.0 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein DUF4207 PF13904.6 CDI84065.1 - 1.4e-05 25.0 43.0 2e-05 24.4 43.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) SOBP PF15279.6 CDI84065.1 - 0.026 15.1 31.1 0.033 14.8 31.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein CCSAP PF15748.5 CDI84065.1 - 0.16 12.2 42.0 0.21 11.7 42.0 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF966 PF06136.13 CDI84065.1 - 0.19 11.5 36.8 0.23 11.1 36.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) SOG2 PF10428.9 CDI84065.1 - 0.25 10.5 38.9 0.31 10.2 38.9 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein GREB1 PF15782.5 CDI84065.1 - 0.33 8.0 41.3 0.43 7.7 41.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NAM-associated PF14303.6 CDI84065.1 - 0.44 11.3 37.5 0.064 14.0 32.7 1.9 1 1 1 2 2 1 0 No apical meristem-associated C-terminal domain TFIIA PF03153.13 CDI84065.1 - 0.54 10.2 61.5 0.85 9.5 61.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Caldesmon PF02029.15 CDI84065.1 - 1.1 7.9 37.6 1.3 7.7 37.6 1.2 1 0 0 1 1 1 0 Caldesmon Draxin PF15550.6 CDI84065.1 - 1.5 8.6 24.3 2 8.2 24.3 1.2 1 0 0 1 1 1 0 Draxin SR-25 PF10500.9 CDI84065.1 - 1.8 8.1 48.5 0.2 11.2 33.9 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Vac7 PF12751.7 CDI84065.1 - 2 7.8 27.5 3.1 7.1 27.5 1.4 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 UPF0564 PF10595.9 CDI84065.1 - 2.6 7.0 46.1 4.1 6.4 46.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 FapA PF03961.13 CDI84065.1 - 2.9 6.4 17.4 3.7 6.0 17.4 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A LAP1C PF05609.12 CDI84065.1 - 3.3 6.7 36.2 4.4 6.3 36.2 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Ribosomal_60s PF00428.19 CDI84065.1 - 4 8.1 15.8 0.27 11.9 10.7 1.7 2 0 0 2 2 1 0 60s Acidic ribosomal protein Hid1 PF12722.7 CDI84065.1 - 4.4 5.3 34.2 5.4 5.0 34.2 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Rrn6 PF10214.9 CDI84065.1 - 6.8 5.0 45.6 9.4 4.6 45.6 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SWI-SNF_Ssr4 PF08549.10 CDI84065.1 - 9.4 4.7 34.7 14 4.2 34.7 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) RskA PF10099.9 CDI84069.1 - 0.0064 16.8 5.0 0.0074 16.6 5.0 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA TMEM51 PF15345.6 CDI84069.1 - 0.019 14.8 8.5 0.02 14.7 8.5 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 tRNA_synt_1c_R2 PF04557.15 CDI84069.1 - 0.037 15.0 10.3 0.053 14.5 10.3 1.3 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 CW_binding_2 PF04122.12 CDI84069.1 - 0.05 14.3 0.1 0.056 14.1 0.1 1.2 1 0 0 1 1 1 0 Putative cell wall binding repeat 2 DUF3899 PF13038.6 CDI84069.1 - 0.28 11.7 0.2 0.33 11.5 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) Glt_symporter PF03616.14 CDI84069.1 - 0.29 9.8 1.5 0.3 9.7 1.5 1.0 1 0 0 1 1 1 0 Sodium/glutamate symporter Presenilin PF01080.17 CDI84069.1 - 0.5 9.1 8.6 0.45 9.2 8.6 1.0 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 CDI84069.1 - 0.52 10.0 6.7 0.45 10.2 6.7 1.1 1 0 0 1 1 1 0 Connexin DUF4834 PF16118.5 CDI84069.1 - 0.59 11.1 10.9 0.65 11.0 10.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3464 PF11947.8 CDI84069.1 - 0.62 9.8 11.5 0.62 9.8 11.5 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 THOC2_N PF16134.5 CDI84069.1 - 0.77 8.3 9.3 0.76 8.3 9.3 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Bac_luciferase PF00296.20 CDI84069.1 - 0.87 8.9 4.5 0.88 8.9 4.5 1.0 1 0 0 1 1 1 0 Luciferase-like monooxygenase Spt20 PF12090.8 CDI84069.1 - 0.9 9.1 24.9 0.85 9.2 24.9 1.1 1 0 0 1 1 1 0 Spt20 family YjeF_N PF03853.15 CDI84069.1 - 1 9.2 4.7 1.2 9.0 4.7 1.0 1 0 0 1 1 1 0 YjeF-related protein N-terminus FAM176 PF14851.6 CDI84069.1 - 1.1 8.9 7.2 1.3 8.6 7.2 1.2 1 0 0 1 1 1 0 FAM176 family DDHD PF02862.17 CDI84069.1 - 1.2 9.2 8.0 1.1 9.3 8.0 1.1 1 0 0 1 1 1 0 DDHD domain CLN3 PF02487.17 CDI84069.1 - 1.3 8.0 5.7 1.3 8.0 5.7 1.0 1 0 0 1 1 1 0 CLN3 protein PNTB PF02233.16 CDI84069.1 - 1.3 7.8 3.5 1.4 7.7 3.5 1.0 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit DUF3682 PF12446.8 CDI84069.1 - 1.4 9.4 19.6 2 8.9 19.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) EIIBC-GUT_N PF03612.14 CDI84069.1 - 3 7.5 10.4 2.9 7.6 10.4 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus EOS1 PF12326.8 CDI84069.1 - 3.1 7.7 4.5 2.9 7.8 4.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein RabGAP-TBC PF00566.18 CDI84069.1 - 3.3 7.3 11.4 3.9 7.1 11.4 1.0 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Peptidase_S49_N PF08496.10 CDI84069.1 - 4.3 7.4 13.5 4.6 7.3 13.5 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Neur_chan_memb PF02932.16 CDI84069.1 - 5.6 7.0 7.0 5 7.1 7.0 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peroxin-13_N PF04088.13 CDI84069.1 - 5.8 7.2 8.3 6.1 7.1 8.3 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region OATP PF03137.20 CDI84069.1 - 8.4 4.6 7.7 8.3 4.6 7.7 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family HTH_15 PF12324.8 CDI84080.1 - 0.049 13.6 2.0 0.078 12.9 0.3 2.3 2 1 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase BUD22 PF09073.10 CDI84080.1 - 0.11 11.8 28.4 0.13 11.6 28.4 1.1 1 0 0 1 1 1 0 BUD22 DUF755 PF05501.11 CDI84080.1 - 0.52 10.6 17.1 0.23 11.7 14.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF755) CDC45 PF02724.14 CDI84080.1 - 2 6.6 13.2 2.5 6.3 13.2 1.2 1 0 0 1 1 1 0 CDC45-like protein RskA PF10099.9 CDI84087.1 - 0.0014 19.0 9.0 0.0017 18.7 9.0 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI84087.1 - 0.14 11.7 7.7 0.14 11.8 7.7 1.2 1 0 0 1 1 1 0 Spt20 family Adeno_PIX PF03955.14 CDI84087.1 - 0.76 10.0 8.8 0.88 9.8 8.8 1.1 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) HSP90 PF00183.18 CDI84093.1 - 3.6e-39 135.1 2.8 1.6e-38 132.9 0.1 2.4 2 1 0 2 2 2 1 Hsp90 protein Ctr PF04145.15 CDI84093.1 - 0.0027 18.3 1.0 0.007 17.0 0.0 2.0 2 0 0 2 2 2 1 Ctr copper transporter family SUIM_assoc PF16619.5 CDI84093.1 - 0.045 13.8 1.5 0.045 13.8 1.5 3.6 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 LRAT PF04970.13 CDI84093.1 - 0.15 12.4 0.6 0.33 11.2 0.1 1.7 2 0 0 2 2 2 0 Lecithin retinol acyltransferase SOBP PF15279.6 CDI84118.1 - 0.34 11.5 29.7 0.49 11.0 29.7 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Ofd1_CTDD PF10637.9 CDI84118.1 - 9.1 5.5 11.4 15 4.8 11.4 1.3 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term Hid1 PF12722.7 CDI84118.1 - 9.5 4.2 20.2 11 4.0 20.2 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3446 PF11928.8 CDI84122.1 - 0.0063 16.8 34.7 0.2 12.0 3.2 3.9 3 0 0 3 3 3 3 Early growth response N-terminal domain DUF3499 PF12005.8 CDI84122.1 - 1.8 9.2 7.7 1.6 9.3 1.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3499) RskA PF10099.9 CDI84122.1 - 2.1 8.6 16.6 1.8 8.8 0.6 3.1 2 1 1 3 3 3 0 Anti-sigma-K factor rskA Macoilin PF09726.9 CDI84134.1 - 7.2e-05 21.6 47.6 7.2e-05 21.6 47.6 2.1 1 1 1 2 2 2 1 Macoilin family SMC_hinge PF06470.13 CDI84134.1 - 9.4e-05 22.7 10.6 9.4e-05 22.7 10.6 5.2 2 2 4 6 6 6 1 SMC proteins Flexible Hinge Domain Dapper PF15268.6 CDI84134.1 - 0.0009 18.2 48.5 0.0009 18.2 48.5 2.2 2 0 0 2 2 2 2 Dapper Med15 PF09606.10 CDI84134.1 - 0.005 15.6 19.6 0.005 15.6 19.6 3.1 2 1 1 3 3 3 1 ARC105 or Med15 subunit of Mediator complex non-fungal SUIM_assoc PF16619.5 CDI84134.1 - 0.014 15.5 3.1 0.014 15.5 3.1 8.9 3 2 2 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 DUF4551 PF15087.6 CDI84134.1 - 4.8 5.9 44.0 0.62 8.8 31.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4551) AF-4 PF05110.13 CDI84139.1 - 0.12 10.4 24.5 0.17 9.9 24.5 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein NARP1 PF12569.8 CDI84139.1 - 0.39 9.6 18.4 0.62 8.9 18.4 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 BAF1_ABF1 PF04684.13 CDI84139.1 - 0.59 9.1 20.1 0.84 8.6 20.1 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SR-25 PF10500.9 CDI84139.1 - 0.64 9.6 26.7 0.17 11.4 22.9 1.9 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 CDI84139.1 - 0.94 7.7 17.9 1.5 7.1 17.9 1.4 1 0 0 1 1 1 0 CDC45-like protein GREB1 PF15782.5 CDI84139.1 - 2.8 5.0 18.3 2.8 4.9 18.3 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SID-1_RNA_chan PF13965.6 CDI84139.1 - 3.2 6.1 6.2 3.8 5.8 6.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Membralin PF09746.9 CDI84139.1 - 3.2 6.7 9.1 3.4 6.6 9.1 1.3 1 0 0 1 1 1 0 Tumour-associated protein TMEM51 PF15345.6 CDI84139.1 - 3.2 7.5 21.4 16 5.3 21.4 2.3 1 1 0 1 1 1 0 Transmembrane protein 51 CSG2 PF16965.5 CDI84139.1 - 3.4 6.5 7.7 6 5.7 7.7 1.5 1 0 0 1 1 1 0 Ceramide synthase regulator PPP4R2 PF09184.11 CDI84139.1 - 3.5 7.2 16.1 6.6 6.2 16.1 1.4 1 0 0 1 1 1 0 PPP4R2 Hid1 PF12722.7 CDI84139.1 - 4.1 5.4 19.3 5.3 5.0 19.3 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4770 PF15994.5 CDI84139.1 - 4.7 7.4 15.1 0.26 11.5 9.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) O-antigen_lig PF13425.6 CDI84139.1 - 4.9 5.8 6.0 5.9 5.6 6.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein OATP PF03137.20 CDI84139.1 - 5.2 5.2 5.5 7.3 4.7 5.5 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Folate_carrier PF01770.18 CDI84139.1 - 7.1 5.2 6.6 11 4.6 6.6 1.4 1 0 0 1 1 1 0 Reduced folate carrier NACHT_N PF17100.5 CDI84157.1 - 0.057 13.3 5.9 0.063 13.1 5.9 1.1 1 0 0 1 1 1 0 N-terminal domain of NWD NACHT-NTPase DUF1189 PF06691.11 CDI84157.1 - 0.06 12.9 0.0 0.06 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) EIF4E-T PF10477.9 CDI84157.1 - 0.14 10.9 9.2 0.15 10.9 9.2 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E TFIIA PF03153.13 CDI84157.1 - 0.23 11.4 15.6 0.27 11.2 15.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI84157.1 - 0.23 10.4 9.0 0.21 10.5 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF2057 PF09829.9 CDI84157.1 - 0.88 9.7 13.2 1.1 9.4 13.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) Spt20 PF12090.8 CDI84157.1 - 1 8.9 18.5 1.2 8.7 18.5 1.1 1 0 0 1 1 1 0 Spt20 family DUF1943 PF09172.11 CDI84157.1 - 1.3 8.1 4.3 2 7.6 3.8 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF1943) PepSY_TM_like_2 PF16357.5 CDI84157.1 - 2.8 7.9 4.9 3.6 7.5 4.9 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like Spt20 PF12090.8 CDI84164.1 - 0.00048 19.8 14.0 0.00048 19.8 14.0 4.8 3 2 1 4 4 4 1 Spt20 family DUF2722 PF10846.8 CDI84164.1 - 0.0036 16.3 11.9 0.0036 16.3 11.9 4.8 3 2 1 4 4 4 1 Protein of unknown function (DUF2722) SRP9-21 PF05486.12 CDI84164.1 - 0.0087 16.4 2.1 0.0087 16.4 2.1 5.0 5 2 0 5 5 5 1 Signal recognition particle 9 kDa protein (SRP9) RskA PF10099.9 CDI84164.1 - 0.01 16.2 19.5 0.01 16.2 19.5 6.8 2 2 4 6 6 6 0 Anti-sigma-K factor rskA Cpn60_TCP1 PF00118.24 CDI84169.1 - 5.7e-24 84.6 1.6 1.1e-11 44.0 0.1 2.2 1 1 0 2 2 2 2 TCP-1/cpn60 chaperonin family Glyco_tran_WecB PF03808.13 CDI84169.1 - 0.0014 18.6 1.1 0.0017 18.4 1.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase WecB/TagA/CpsF family CDK2AP PF09806.9 CDI84169.1 - 0.033 14.2 5.0 0.037 14.1 5.0 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DUF3995 PF13160.6 CDI84169.1 - 0.08 13.3 2.7 0.13 12.6 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3995) Gly_rich_SFCGS PF14272.6 CDI84169.1 - 0.38 10.8 5.6 0.81 9.7 2.0 2.1 1 1 1 2 2 2 0 Glycine-rich SFCGS Calpain_inhib PF00748.19 CDI84169.1 - 9.9 6.7 7.4 10 6.6 6.2 1.5 1 1 1 2 2 2 0 Calpain inhibitor RIFIN PF02009.16 CDI84173.1 - 2.2 8.1 32.6 2.6 7.9 32.6 1.0 1 0 0 1 1 1 0 Rifin PAT1 PF09770.9 CDI84173.1 - 3.2 5.9 76.4 3.6 5.7 76.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CCSAP PF15748.5 CDI84173.1 - 3.4 7.8 54.8 5.1 7.2 54.8 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Macoilin PF09726.9 CDI84173.1 - 5.2 5.5 43.0 6.7 5.1 43.0 1.1 1 0 0 1 1 1 0 Macoilin family Asp-B-Hydro_N PF05279.11 CDI84173.1 - 8.2 6.4 40.6 9.4 6.2 40.6 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region TFIIA PF03153.13 CDI84175.1 - 1.9 8.4 43.6 2.3 8.1 43.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI84192.1 - 0.12 12.7 47.5 0.085 13.2 0.9 4.1 1 1 2 3 3 3 0 Anti-sigma-K factor rskA DUF3040 PF11239.8 CDI84192.1 - 3.5 8.0 8.7 8 6.8 0.6 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) Ribosomal_60s PF00428.19 CDI84192.1 - 8.6 7.0 30.1 1.4 9.6 7.3 4.0 3 1 1 4 4 4 0 60s Acidic ribosomal protein RskA PF10099.9 CDI84196.1 - 0.00084 19.7 15.4 0.00084 19.7 15.4 3.5 1 1 2 3 3 2 1 Anti-sigma-K factor rskA Pex14_N PF04695.13 CDI84196.1 - 0.0047 17.6 36.2 0.0047 17.6 36.2 3.1 2 1 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4337 PF14235.6 CDI84196.1 - 0.008 16.3 15.0 0.008 16.3 15.0 2.6 2 1 0 2 2 1 1 Domain of unknown function (DUF4337) DUF4179 PF13786.6 CDI84196.1 - 0.016 15.6 0.0 0.016 15.6 0.0 2.7 1 1 1 2 2 1 0 Domain of unknown function (DUF4179) CSG2 PF16965.5 CDI84196.1 - 0.027 13.4 18.5 0.011 14.8 6.4 2.2 2 0 0 2 2 2 0 Ceramide synthase regulator MFS_1_like PF12832.7 CDI84196.1 - 0.056 12.3 0.0 0.13 11.0 0.0 1.8 1 1 0 1 1 1 0 MFS_1 like family Presenilin PF01080.17 CDI84196.1 - 0.2 10.4 48.8 0.062 12.1 25.8 2.1 2 0 0 2 2 2 0 Presenilin Ni_hydr_CYTB PF01292.20 CDI84196.1 - 0.78 9.3 4.0 23 4.5 2.3 2.9 1 1 0 2 2 2 0 Prokaryotic cytochrome b561 ETRAMP PF09716.10 CDI84196.1 - 4.3 7.5 7.8 1.4 9.0 1.1 3.0 2 2 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) O-antigen_lig PF13425.6 CDI84196.1 - 4.3 6.0 19.2 4.4 6.0 10.6 2.1 2 0 0 2 2 2 0 O-antigen ligase like membrane protein DUF2052 PF09747.9 CDI84196.1 - 5.3 7.1 40.5 5.2 7.1 7.6 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) RskA PF10099.9 CDI84197.1 - 4.1e-06 27.2 1.6 4.1e-06 27.2 1.6 6.4 3 3 3 6 6 3 1 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI84197.1 - 2e-05 23.8 47.5 0.00016 20.8 9.5 4.3 4 0 0 4 4 3 3 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI84197.1 - 0.00037 20.2 60.2 0.027 14.1 10.7 4.0 4 0 0 4 4 4 3 Spt20 family DUF1043 PF06295.12 CDI84197.1 - 0.0075 16.3 6.0 0.0075 16.3 6.0 3.6 3 0 0 3 3 3 1 Protein of unknown function (DUF1043) DUF1645 PF07816.11 CDI84197.1 - 0.016 15.8 2.3 0.016 15.8 2.3 7.6 6 3 2 8 8 5 0 Protein of unknown function (DUF1645) DUF3506 PF12014.8 CDI84197.1 - 0.18 11.8 6.3 2.2 8.3 1.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3506) Afi1 PF07792.12 CDI84197.1 - 0.3 11.6 7.9 1.1 9.7 0.3 3.6 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking eIF-3_zeta PF05091.12 CDI84197.1 - 0.37 9.7 15.5 0.64 8.9 2.6 3.2 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Thg1C PF14413.6 CDI84197.1 - 0.49 10.6 14.6 0.87 9.8 3.3 3.6 3 0 0 3 3 3 0 Thg1 C terminal domain Tau95_N PF17682.1 CDI84197.1 - 0.72 10.1 8.0 1.5 9.1 0.4 3.4 3 0 0 3 3 3 0 Tau95 Triple barrel domain Mlh1_C PF16413.5 CDI84197.1 - 1.1 8.6 14.0 1.3 8.3 0.3 3.5 3 0 0 3 3 3 0 DNA mismatch repair protein Mlh1 C-terminus Gaa1 PF04114.14 CDI84197.1 - 1.4 7.8 7.0 0.56 9.2 0.3 2.5 3 0 0 3 3 3 0 Gaa1-like, GPI transamidase component EphA2_TM PF14575.6 CDI84197.1 - 2 9.4 10.2 3.1 8.8 0.6 3.9 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain TFIIA PF03153.13 CDI84197.1 - 2.1 8.2 88.9 0.64 10.0 22.3 3.5 2 1 1 3 3 3 0 Transcription factor IIA, alpha/beta subunit FHIPEP PF00771.20 CDI84197.1 - 2.2 6.6 17.8 0.067 11.7 1.0 3.3 3 0 0 3 3 3 0 FHIPEP family Connexin PF00029.19 CDI84197.1 - 4.4 7.0 8.0 3 7.6 0.2 3.1 3 0 0 3 3 3 0 Connexin FAM176 PF14851.6 CDI84197.1 - 4.9 6.8 9.3 3.4 7.3 0.3 3.6 3 0 0 3 3 3 0 FAM176 family NPR1_interact PF15699.5 CDI84197.1 - 5.9 7.6 20.0 0.22 12.2 0.7 4.3 4 0 0 4 4 4 0 NPR1 interacting TFB6 PF17110.5 CDI84197.1 - 5.9 6.6 8.7 7.5 6.3 1.0 3.1 3 0 0 3 3 3 0 Subunit 11 of the general transcription factor TFIIH PAT1 PF09770.9 CDI84197.1 - 9.1 4.4 39.8 0.62 8.3 5.1 3.2 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 DUF3112 PF11309.8 CDI84208.1 - 6 6.2 8.4 1.1 8.7 0.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) AAA_23 PF13476.6 CDI84208.1 - 7 7.1 40.2 4.1 7.8 4.1 3.3 3 0 0 3 3 3 0 AAA domain SUIM_assoc PF16619.5 CDI84222.1 - 0.00099 19.1 2.7 0.0015 18.6 2.7 1.5 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 BPD_transp_2 PF02653.16 CDI84222.1 - 0.0062 15.7 1.8 0.0062 15.7 1.8 2.1 1 1 0 2 2 2 1 Branched-chain amino acid transport system / permease component DUF3687 PF12459.8 CDI84222.1 - 0.13 11.8 0.1 0.22 11.1 0.1 1.3 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein DUF5423 PF17461.2 CDI84222.1 - 0.67 8.8 7.5 0.62 8.9 6.8 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5423) Spt20 PF12090.8 CDI84222.1 - 1.7 8.2 9.9 2.1 7.9 9.9 1.1 1 0 0 1 1 1 0 Spt20 family DUF92 PF01940.16 CDI84222.1 - 1.9 7.8 11.9 0.04 13.3 1.4 2.3 2 0 0 2 2 2 0 Integral membrane protein DUF92 Spt20 PF12090.8 CDI84229.1 - 8.1e-06 25.6 42.9 0.0027 17.4 28.9 2.3 2 0 0 2 2 2 2 Spt20 family SR-25 PF10500.9 CDI84229.1 - 0.0024 17.5 13.8 0.0024 17.5 13.8 3.1 2 1 1 3 3 2 1 Nuclear RNA-splicing-associated protein MecA PF05389.12 CDI84229.1 - 0.0027 17.4 6.9 0.2 11.3 3.4 2.1 2 0 0 2 2 2 2 Negative regulator of genetic competence (MecA) SpoIIP PF07454.11 CDI84229.1 - 0.0043 16.6 7.1 0.0067 15.9 2.8 2.1 2 0 0 2 2 2 1 Stage II sporulation protein P (SpoIIP) AAA_23 PF13476.6 CDI84229.1 - 0.037 14.5 10.5 0.19 12.2 4.8 2.1 2 0 0 2 2 2 0 AAA domain eIF-3_zeta PF05091.12 CDI84229.1 - 0.044 12.8 17.3 0.034 13.1 8.5 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF5523 PF17661.1 CDI84229.1 - 0.075 12.7 9.6 0.18 11.5 5.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) RR_TM4-6 PF06459.12 CDI84229.1 - 0.083 12.7 8.5 0.064 13.1 3.0 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF5327 PF17261.2 CDI84229.1 - 0.14 13.0 20.7 1.2 10.0 13.2 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5327) G0-G1_switch_2 PF15103.6 CDI84229.1 - 0.14 12.6 13.8 0.53 10.7 9.0 2.5 2 0 0 2 2 2 0 G0/G1 switch protein 2 Sarcoglycan_2 PF05510.13 CDI84229.1 - 0.18 10.6 6.9 2.5 6.8 0.1 2.1 2 0 0 2 2 2 0 Sarcoglycan alpha/epsilon CLN3 PF02487.17 CDI84229.1 - 0.18 10.8 9.6 0.78 8.7 4.8 2.1 2 0 0 2 2 2 0 CLN3 protein FAM150 PF15129.6 CDI84229.1 - 0.3 11.3 11.7 2 8.6 5.8 2.3 2 0 0 2 2 2 0 FAM150 family RPA43_OB PF17875.1 CDI84229.1 - 0.35 11.5 11.8 0.16 12.6 1.0 2.8 2 1 0 2 2 2 0 RPA43 OB domain in RNA Pol I DUF2126 PF09899.9 CDI84229.1 - 0.51 8.4 7.1 0.062 11.4 2.1 1.8 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) TMEM247 PF15444.6 CDI84229.1 - 0.56 10.2 10.2 4.7 7.2 4.5 2.4 2 0 0 2 2 2 0 Transmembrane protein 247 DUF1764 PF08576.10 CDI84229.1 - 0.58 11.1 11.7 5.7 7.9 7.5 2.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) RIC3 PF15361.6 CDI84229.1 - 0.7 10.3 8.4 1.8 9.0 4.2 2.4 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 DUF4638 PF15472.6 CDI84229.1 - 0.72 9.5 7.8 0.48 10.1 3.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) DUF3408 PF11888.8 CDI84229.1 - 0.94 9.6 12.8 0.71 10.0 7.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) RED_N PF07808.13 CDI84229.1 - 0.99 8.9 19.0 2.3 7.7 0.1 2.4 2 0 0 2 2 2 0 RED-like protein N-terminal region V_ATPase_I PF01496.19 CDI84229.1 - 1.1 7.1 11.8 0.93 7.3 7.4 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Peptidase_S49_N PF08496.10 CDI84229.1 - 1.2 9.2 12.4 12 5.9 0.1 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Afi1 PF07792.12 CDI84229.1 - 1.9 9.0 14.1 4.9 7.6 8.6 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CSG2 PF16965.5 CDI84229.1 - 2.3 7.1 5.0 0.55 9.1 1.6 1.6 2 0 0 2 2 2 0 Ceramide synthase regulator TERB2 PF15101.6 CDI84229.1 - 2.8 7.9 25.3 6.6 6.7 17.3 2.4 2 0 0 2 2 2 0 Telomere-associated protein TERB2 EphA2_TM PF14575.6 CDI84229.1 - 2.8 8.9 13.5 2.4 9.1 0.5 3.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain GET2 PF08690.10 CDI84229.1 - 3 7.4 19.0 1.4 8.6 0.3 2.3 2 0 0 2 2 2 0 GET complex subunit GET2 MDM31_MDM32 PF08118.11 CDI84229.1 - 3.2 6.3 8.4 2.1 6.9 4.5 2.0 2 0 0 2 2 2 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF4820 PF16091.5 CDI84229.1 - 3.4 7.0 13.2 2.7 7.3 8.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) EIIBC-GUT_N PF03612.14 CDI84229.1 - 3.6 7.3 14.4 3.9 7.2 9.3 2.3 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Baculo_PP31 PF05311.11 CDI84229.1 - 3.8 6.9 13.2 2.7 7.4 8.2 2.1 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Orf78 PF06024.12 CDI84229.1 - 4.4 7.6 12.6 1.7 9.0 6.7 2.6 2 0 0 2 2 2 0 Orf78 (ac78) Peptidase_M17_N PF02789.17 CDI84229.1 - 5 7.0 13.7 26 4.7 0.0 2.4 2 0 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain Rxt3 PF08642.10 CDI84229.1 - 5.5 7.8 10.8 0.73 10.6 2.0 2.7 2 1 1 3 3 2 0 Histone deacetylation protein Rxt3 GT87 PF09594.10 CDI84229.1 - 6.3 6.4 20.8 0.046 13.4 8.9 2.1 1 1 1 2 2 2 0 Glycosyltransferase family 87 DUF2370 PF10176.9 CDI84229.1 - 7.3 6.2 8.7 4.8 6.8 3.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) NST1 PF13945.6 CDI84229.1 - 7.5 6.6 24.8 0.3 11.2 9.9 2.9 3 0 0 3 3 3 0 Salt tolerance down-regulator DUF3381 PF11861.8 CDI84229.1 - 9 6.1 19.9 4.5 7.0 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) DUF1980 PF09323.10 CDI84229.1 - 9 6.2 13.4 17 5.2 8.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) XRCC4 PF06632.12 CDI84229.1 - 9.4 5.0 16.9 7.4 5.3 12.0 2.1 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 PAT1 PF09770.9 CDI84234.1 - 0.009 14.3 71.2 0.0099 14.2 71.2 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 HSP70 PF00012.20 CDI84234.1 - 0.28 9.3 28.9 0.27 9.4 28.9 1.2 1 0 0 1 1 1 0 Hsp70 protein Caldesmon PF02029.15 CDI84234.1 - 1.5 7.5 55.2 1.9 7.2 55.2 1.1 1 0 0 1 1 1 0 Caldesmon Activator_LAG-3 PF11498.8 CDI84235.1 - 0.0048 15.9 7.9 0.0048 15.9 7.9 1.1 1 0 0 1 1 1 1 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI84235.1 - 0.33 10.5 11.9 0.32 10.6 11.9 1.0 1 0 0 1 1 1 0 Spt20 family TALPID3 PF15324.6 CDI84235.1 - 0.35 8.5 10.9 0.39 8.3 10.9 1.0 1 0 0 1 1 1 0 Hedgehog signalling target DUF2722 PF10846.8 CDI84235.1 - 0.4 9.6 7.8 0.37 9.7 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) 40S_SA_C PF16122.5 CDI84235.1 - 0.65 11.4 11.8 0.79 11.1 11.8 1.1 1 0 0 1 1 1 0 40S ribosomal protein SA C-terminus PHD_3 PF13922.6 CDI84235.1 - 1.7 9.1 5.4 2.3 8.7 5.4 1.3 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx Roughex PF06020.11 CDI84235.1 - 5.7 5.9 8.8 5.9 5.9 8.8 1.0 1 0 0 1 1 1 0 Drosophila roughex protein DUF3138 PF11336.8 CDI84235.1 - 8.1 4.9 13.5 8.8 4.8 13.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Exo_endo_phos PF03372.23 CDI84241.1 - 1.9e-11 43.9 0.7 1e-10 41.6 0.1 2.2 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family AAA PF00004.29 CDI84243.1 - 9.1e-39 132.9 0.0 2.9e-38 131.3 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CDI84243.1 - 2.2e-19 69.1 0.1 4.5e-19 68.1 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CDI84243.1 - 5.7e-12 45.2 0.1 1.3e-11 44.1 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CDI84243.1 - 2.3e-06 27.7 0.1 1.2e-05 25.3 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDI84243.1 - 5.1e-05 23.7 0.6 0.0046 17.4 0.0 2.6 2 1 1 3 3 2 1 AAA ATPase domain RuvB_N PF05496.12 CDI84243.1 - 9.4e-05 22.2 0.0 0.00021 21.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CDI84243.1 - 0.0004 20.5 0.0 0.0018 18.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CDI84243.1 - 0.0019 18.5 0.6 0.089 13.1 0.1 2.5 1 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CDI84243.1 - 0.0031 17.7 0.0 0.0094 16.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CDI84243.1 - 0.0037 16.7 0.1 0.015 14.7 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 CDI84243.1 - 0.007 15.7 0.2 0.16 11.3 0.0 2.4 2 0 0 2 2 2 1 KaiC PhoH PF02562.16 CDI84243.1 - 0.014 14.8 0.0 0.03 13.8 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein DUF815 PF05673.13 CDI84243.1 - 0.017 14.3 0.0 0.03 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 CDI84243.1 - 0.026 14.2 0.0 0.052 13.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 CDI84243.1 - 0.036 13.3 0.9 0.25 10.5 0.0 2.1 1 1 1 2 2 2 0 TIP49 P-loop domain AAA_24 PF13479.6 CDI84243.1 - 0.044 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 CDI84243.1 - 0.07 12.8 0.0 0.33 10.6 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain CENP-F_leu_zip PF10473.9 CDI84243.1 - 0.077 13.0 2.1 0.35 10.9 1.1 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_7 PF12775.7 CDI84243.1 - 0.11 12.0 0.1 0.35 10.4 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region ZapB PF06005.12 CDI84243.1 - 0.11 12.9 3.6 0.21 12.1 1.7 2.4 2 0 0 2 2 2 0 Cell division protein ZapB Hydin_ADK PF17213.3 CDI84244.1 - 0.073 13.4 2.8 0.091 13.0 2.8 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain RskA PF10099.9 CDI84261.1 - 1.2e-05 25.7 1.4 2.3e-05 24.8 1.4 1.4 1 1 0 1 1 1 1 Anti-sigma-K factor rskA TraT PF05818.12 CDI84261.1 - 0.0031 17.2 1.7 0.0042 16.8 1.7 1.2 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein Dehydrin PF00257.19 CDI84261.1 - 0.0052 17.4 2.8 0.029 14.9 2.8 1.8 1 1 0 1 1 1 1 Dehydrin TCL1_MTCP1 PF01840.17 CDI84261.1 - 0.0063 16.1 2.1 0.0083 15.8 2.1 1.2 1 0 0 1 1 1 1 TCL1/MTCP1 family Peptidase_S49_N PF08496.10 CDI84261.1 - 0.0092 16.1 5.1 0.011 15.8 5.1 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal ECSCR PF15820.5 CDI84261.1 - 0.047 13.5 0.3 0.049 13.5 0.3 1.2 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Ctr PF04145.15 CDI84261.1 - 0.17 12.5 1.0 0.21 12.2 1.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family EphA2_TM PF14575.6 CDI84261.1 - 0.56 11.1 12.3 1.8 9.5 12.3 1.8 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ODV-E18 PF10717.9 CDI84261.1 - 3.4 7.6 6.8 14 5.6 0.6 2.2 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 DUF3357 PF11837.8 CDI84261.1 - 4.7 7.7 10.5 12 6.4 10.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) SP_C-Propep PF08999.10 CDI84261.1 - 8.4 6.3 11.7 13 5.6 11.5 1.4 1 1 0 1 1 1 0 Surfactant protein C, N terminal propeptide DUF668 PF05003.12 CDI84283.1 - 0.41 11.1 9.3 2.6 8.6 9.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF668) RNase_J_C PF17770.1 CDI84283.1 - 0.54 11.4 3.3 0.57 11.3 2.9 1.3 1 1 0 1 1 1 0 Ribonuclease J C-terminal domain Inositol_P PF00459.25 CDI84283.1 - 1.9 7.9 7.2 2 7.8 7.2 1.0 1 0 0 1 1 1 0 Inositol monophosphatase family PEPCK_GTP PF00821.18 CDI84283.1 - 2.7 6.7 8.3 3.3 6.4 8.3 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain VitD-bind_III PF09164.10 CDI84283.1 - 4 7.5 6.5 5.8 7.0 1.3 2.1 1 1 1 2 2 2 0 Vitamin D binding protein, domain III FHIPEP PF00771.20 CDI84283.1 - 4 5.8 16.4 4.2 5.7 16.4 1.0 1 0 0 1 1 1 0 FHIPEP family HI0933_like PF03486.14 CDI84283.1 - 5.6 5.6 15.6 6.4 5.4 15.6 1.1 1 0 0 1 1 1 0 HI0933-like protein HD_2 PF12917.7 CDI84283.1 - 8.4 6.1 10.7 6.3 6.5 5.1 2.0 1 1 1 2 2 2 0 HD containing hydrolase-like enzyme Prenyltrans PF00432.21 CDI84294.1 - 1e-38 130.7 22.6 6.7e-09 35.3 0.2 6.4 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CDI84294.1 - 4.2e-07 29.3 0.0 0.033 13.3 0.0 3.6 1 1 3 4 4 4 3 Squalene-hopene cyclase N-terminal domain SR-25 PF10500.9 CDI84294.1 - 7.3 6.1 11.1 12 5.5 11.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MFS_1 PF07690.16 CDI84295.1 - 1.6e-16 60.2 27.7 1.3e-11 44.0 13.1 2.6 1 1 1 3 3 3 2 Major Facilitator Superfamily DUF373 PF04123.13 CDI84295.1 - 0.089 12.2 1.8 0.14 11.6 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) CDC50 PF03381.15 CDI84297.1 - 1.8e-26 93.3 0.0 2.7e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Mlo PF03094.15 CDI84298.1 - 1.3e-05 23.8 9.6 0.00015 20.3 2.1 3.2 1 1 2 3 3 3 2 Mlo family EF-hand_6 PF13405.6 CDI84298.1 - 0.0043 16.9 1.7 0.018 14.9 1.7 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 CDI84298.1 - 0.01 16.3 0.1 0.028 14.9 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.6 CDI84298.1 - 0.078 12.8 2.0 0.17 11.7 2.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 CDI84298.1 - 0.12 12.0 2.4 0.59 9.8 2.4 2.2 1 0 0 1 1 1 0 EF hand Caleosin PF05042.13 CDI84298.1 - 0.22 11.4 1.7 15 5.4 0.0 3.3 3 1 1 4 4 4 0 Caleosin related protein EF-hand_5 PF13202.6 CDI84298.1 - 0.41 10.2 1.6 1 9.0 1.6 1.7 1 0 0 1 1 1 0 EF hand DFP PF04127.15 CDI84299.1 - 1.1e-09 38.4 0.0 2.4e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein MecA PF05389.12 CDI84299.1 - 0.013 15.1 4.2 0.12 12.0 0.5 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) CPSF100_C PF13299.6 CDI84299.1 - 0.028 14.6 1.8 0.028 14.6 1.8 2.5 2 1 0 2 2 1 0 Cleavage and polyadenylation factor 2 C-terminal CLN3 PF02487.17 CDI84299.1 - 0.078 12.0 3.3 0.091 11.8 0.1 2.0 2 0 0 2 2 2 0 CLN3 protein DUF2250 PF10007.9 CDI84299.1 - 0.079 13.1 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) EPL1 PF10513.9 CDI84299.1 - 0.1 13.0 18.0 0.024 15.0 7.2 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like AAA_23 PF13476.6 CDI84299.1 - 0.18 12.3 10.3 0.18 12.3 1.9 2.2 2 0 0 2 2 2 0 AAA domain G6B PF15096.6 CDI84299.1 - 0.32 10.8 2.3 0.29 10.9 0.2 1.8 2 0 0 2 2 2 0 G6B family Coilin_N PF15862.5 CDI84299.1 - 0.36 10.6 13.1 0.13 12.1 2.9 2.5 2 0 0 2 2 2 0 Coilin N-terminus DUF2722 PF10846.8 CDI84299.1 - 0.37 9.7 31.6 0.0071 15.3 10.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) MCD PF05292.11 CDI84299.1 - 0.48 10.0 3.1 0.66 9.5 0.2 2.0 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase C-terminal domain EIIBC-GUT_N PF03612.14 CDI84299.1 - 0.54 10.0 10.9 0.47 10.2 3.2 2.7 3 0 0 3 3 3 0 Sorbitol phosphotransferase enzyme II N-terminus Spt20 PF12090.8 CDI84299.1 - 0.56 9.8 43.7 0.61 9.7 22.8 2.2 2 0 0 2 2 2 0 Spt20 family Serinc PF03348.15 CDI84299.1 - 0.65 8.9 5.3 0.1 11.5 0.5 1.8 2 0 0 2 2 2 0 Serine incorporator (Serinc) Peroxin-13_N PF04088.13 CDI84299.1 - 0.71 10.1 3.4 2.8 8.2 0.2 2.3 2 0 0 2 2 2 0 Peroxin 13, N-terminal region SpoIIP PF07454.11 CDI84299.1 - 0.75 9.2 15.4 0.15 11.5 6.7 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) EOS1 PF12326.8 CDI84299.1 - 0.97 9.3 3.6 8.3 6.3 0.4 2.1 2 0 0 2 2 2 0 N-glycosylation protein DUF2052 PF09747.9 CDI84299.1 - 2 8.5 21.8 0.21 11.7 9.9 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) TMEM51 PF15345.6 CDI84299.1 - 5.7 6.7 21.0 0.61 9.9 9.4 2.3 2 0 0 2 2 2 0 Transmembrane protein 51 Tim54 PF11711.8 CDI84299.1 - 6.7 5.4 16.4 1.3 7.7 9.0 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 CSG2 PF16965.5 CDI84299.1 - 9.1 5.1 6.0 1.1 8.1 0.8 1.8 2 0 0 2 2 2 0 Ceramide synthase regulator Nop53 PF07767.11 CDI84299.1 - 9.1 5.6 28.0 5.4 6.3 6.9 2.1 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) TPR_1 PF00515.28 CDI84301.1 - 8.2e-13 47.6 0.8 7.5e-07 28.7 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDI84301.1 - 6.9e-07 28.9 0.4 1.7e-05 24.5 0.0 3.6 4 0 0 4 4 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDI84301.1 - 2.9e-05 24.1 1.2 2.9e-05 24.1 1.2 2.5 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDI84301.1 - 0.0019 18.3 0.4 0.046 14.0 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat Presenilin PF01080.17 CDI84301.1 - 0.002 16.9 24.5 0.0025 16.6 24.5 1.2 1 0 0 1 1 1 1 Presenilin DUF2828 PF11443.8 CDI84301.1 - 0.0046 15.1 19.8 0.0058 14.8 19.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) V_ATPase_I PF01496.19 CDI84301.1 - 0.0082 14.1 21.1 0.0096 13.9 21.1 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF4045 PF13254.6 CDI84301.1 - 0.017 14.8 19.0 0.021 14.5 19.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) AMP-binding PF00501.28 CDI84301.1 - 0.023 13.3 3.4 0.058 12.0 3.4 1.7 1 1 0 1 1 1 0 AMP-binding enzyme Myc_N PF01056.18 CDI84301.1 - 0.029 14.3 21.4 0.084 12.8 21.4 1.7 1 1 0 1 1 1 0 Myc amino-terminal region PAT1 PF09770.9 CDI84301.1 - 0.031 12.6 38.1 0.038 12.3 38.1 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CENP-N PF05238.13 CDI84301.1 - 0.078 12.3 22.0 0.099 11.9 22.0 1.1 1 0 0 1 1 1 0 Kinetochore protein CHL4 like PPL5 PF18168.1 CDI84301.1 - 0.083 12.2 15.8 0.13 11.6 15.8 1.4 1 0 0 1 1 1 0 Prim-pol family 5 GREB1 PF15782.5 CDI84301.1 - 0.093 9.8 19.6 0.091 9.9 19.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TPR_10 PF13374.6 CDI84301.1 - 0.1 12.5 0.1 0.1 12.5 0.1 3.8 4 1 1 5 5 2 0 Tetratricopeptide repeat CCSAP PF15748.5 CDI84301.1 - 0.13 12.4 26.3 0.21 11.8 26.3 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 CDI84301.1 - 0.16 11.0 26.1 0.23 10.5 26.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 CDI84301.1 - 0.18 10.1 24.3 0.23 9.7 24.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2126 PF09899.9 CDI84301.1 - 0.19 9.7 12.6 0.28 9.2 12.6 1.4 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF4638 PF15472.6 CDI84301.1 - 0.24 11.1 19.9 0.33 10.6 19.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) ALMT PF11744.8 CDI84301.1 - 0.28 10.0 21.3 0.35 9.6 21.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Cellulose_synt PF03552.14 CDI84301.1 - 0.29 9.6 8.7 0.35 9.3 8.7 1.2 1 0 0 1 1 1 0 Cellulose synthase DUF3295 PF11702.8 CDI84301.1 - 0.3 10.4 24.4 0.41 10.0 24.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DUF913 PF06025.12 CDI84301.1 - 0.32 9.9 17.9 0.054 12.5 14.2 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) SAPS PF04499.15 CDI84301.1 - 0.33 9.7 19.1 0.4 9.4 19.1 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.16 CDI84301.1 - 0.45 10.5 22.4 0.69 9.9 22.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 CDI84301.1 - 0.49 9.6 14.6 0.63 9.2 14.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SID-1_RNA_chan PF13965.6 CDI84301.1 - 0.51 8.7 10.5 0.59 8.5 10.5 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Hamartin PF04388.12 CDI84301.1 - 0.55 8.8 26.1 0.63 8.6 26.1 1.0 1 0 0 1 1 1 0 Hamartin protein MDM10 PF12519.8 CDI84301.1 - 0.57 9.0 21.0 0.75 8.6 21.0 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 XRN_M PF17846.1 CDI84301.1 - 0.62 8.9 23.2 0.84 8.5 23.2 1.2 1 0 0 1 1 1 0 Xrn1 helical domain PA26 PF04636.13 CDI84301.1 - 0.72 8.7 17.7 0.94 8.3 17.7 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Connexin PF00029.19 CDI84301.1 - 0.74 9.5 26.6 55 3.4 26.5 2.2 1 1 0 1 1 1 0 Connexin Caldesmon PF02029.15 CDI84301.1 - 0.75 8.5 34.7 0.93 8.2 34.7 1.1 1 0 0 1 1 1 0 Caldesmon Lin-8 PF03353.15 CDI84301.1 - 0.77 9.3 29.1 1.2 8.7 29.1 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CAF1 PF04857.20 CDI84301.1 - 0.77 8.9 17.0 1 8.5 17.0 1.3 1 0 0 1 1 1 0 CAF1 family ribonuclease PPP4R2 PF09184.11 CDI84301.1 - 0.81 9.2 19.8 1.2 8.6 19.8 1.2 1 0 0 1 1 1 0 PPP4R2 DUF966 PF06136.13 CDI84301.1 - 1.8 8.2 20.5 2.1 8.0 20.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) NOA36 PF06524.12 CDI84301.1 - 2.7 7.2 17.5 4.4 6.5 17.5 1.3 1 0 0 1 1 1 0 NOA36 protein CobT PF06213.12 CDI84301.1 - 3 7.2 42.1 7.5 5.9 42.1 1.6 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Peptidase_S64 PF08192.11 CDI84301.1 - 3.6 6.0 24.6 4.4 5.7 24.6 1.1 1 0 0 1 1 1 0 Peptidase family S64 Hid1 PF12722.7 CDI84301.1 - 4.6 5.2 27.1 5.6 5.0 27.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Dicty_REP PF05086.12 CDI84301.1 - 6 4.7 18.5 7.1 4.5 18.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DHHW PF14286.6 CDI84301.1 - 6.8 5.9 10.3 9.9 5.4 10.3 1.2 1 0 0 1 1 1 0 DHHW protein Ndc1_Nup PF09531.10 CDI84301.1 - 9.7 4.7 24.3 12 4.4 24.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAM70 PF14967.6 CDI84301.1 - 9.8 5.5 8.9 13 5.1 8.9 1.3 1 0 0 1 1 1 0 FAM70 protein Nop53 PF07767.11 CDI84313.1 - 0.28 10.5 25.8 0.3 10.4 25.8 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Ferlin_C PF16165.5 CDI84313.1 - 0.63 10.0 6.5 0.69 9.8 6.5 1.2 1 0 0 1 1 1 0 Ferlin C-terminus Presenilin PF01080.17 CDI84313.1 - 0.93 8.2 24.1 0.98 8.1 24.1 1.0 1 0 0 1 1 1 0 Presenilin ASD2 PF08687.11 CDI84313.1 - 1.1 8.8 20.1 1.1 8.7 20.1 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 XRN_M PF17846.1 CDI84313.1 - 1.6 7.6 15.9 1.7 7.5 15.9 1.0 1 0 0 1 1 1 0 Xrn1 helical domain RR_TM4-6 PF06459.12 CDI84313.1 - 3.8 7.2 24.4 4.2 7.1 24.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Slu7 PF11708.8 CDI84313.1 - 5 6.8 25.1 5.5 6.7 25.1 1.0 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor CPSF100_C PF13299.6 CDI84313.1 - 7.6 6.7 18.6 9.5 6.4 18.6 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Apt1 PF10351.9 CDI84313.1 - 7.6 5.3 17.7 8 5.2 17.7 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4647 PF15504.6 CDI84313.1 - 8.1 5.4 22.5 8.6 5.3 22.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) RNA_pol_Rpc4 PF05132.14 CDI84313.1 - 8.1 6.9 20.7 12 6.3 20.7 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDK2AP PF09806.9 CDI84313.1 - 8.2 6.4 25.2 9.4 6.2 25.2 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein SpoIIP PF07454.11 CDI84313.1 - 8.8 5.7 21.0 12 5.2 21.0 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PI3K_1B_p101 PF10486.9 CDI84325.1 - 0.001 17.0 21.6 0.0012 16.8 21.6 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SprA-related PF12118.8 CDI84325.1 - 0.0041 16.3 33.2 0.0041 16.3 33.2 2.0 2 0 0 2 2 2 1 SprA-related family CDC45 PF02724.14 CDI84325.1 - 0.013 13.8 19.9 0.018 13.4 19.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Hamartin PF04388.12 CDI84325.1 - 0.069 11.8 29.2 0.092 11.4 29.2 1.2 1 0 0 1 1 1 0 Hamartin protein SART-1 PF03343.13 CDI84325.1 - 0.13 10.8 21.4 0.16 10.5 21.4 1.1 1 0 0 1 1 1 0 SART-1 family Peptidase_S49_N PF08496.10 CDI84325.1 - 0.15 12.1 17.0 1.1 9.3 1.0 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal PBP1_TM PF14812.6 CDI84325.1 - 0.16 12.4 8.1 0.082 13.3 1.3 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal LAP1C PF05609.12 CDI84325.1 - 0.16 11.0 30.4 0.19 10.7 30.4 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DDRGK PF09756.9 CDI84325.1 - 0.34 10.5 27.0 1.1 8.9 12.6 2.0 2 0 0 2 2 2 0 DDRGK domain LptF_LptG PF03739.14 CDI84325.1 - 0.45 9.3 2.7 0.58 8.9 2.7 1.2 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG U1snRNP70_N PF12220.8 CDI84325.1 - 0.59 10.8 21.0 1.3 9.7 3.0 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Utp14 PF04615.13 CDI84325.1 - 1.3 7.5 29.0 1.7 7.1 29.0 1.1 1 0 0 1 1 1 0 Utp14 protein Joubert PF15392.6 CDI84325.1 - 1.7 8.3 27.9 2.1 8.0 27.9 1.1 1 0 0 1 1 1 0 Joubert syndrome-associated SOBP PF15279.6 CDI84325.1 - 1.8 9.1 29.3 2.2 8.8 29.3 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein MAS20 PF02064.15 CDI84325.1 - 2.4 8.3 21.8 5 7.2 8.4 2.5 2 0 0 2 2 2 0 MAS20 protein import receptor PPP4R2 PF09184.11 CDI84325.1 - 2.4 7.6 22.3 3.6 7.1 22.3 1.2 1 0 0 1 1 1 0 PPP4R2 Otopetrin PF03189.13 CDI84325.1 - 2.6 6.8 16.4 3.4 6.4 16.4 1.1 1 0 0 1 1 1 0 Otopetrin PAT1 PF09770.9 CDI84325.1 - 4.5 5.4 39.1 5.5 5.1 39.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2370 PF10176.9 CDI84325.1 - 4.6 6.8 14.1 4.4 6.9 13.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2370) Pinin_SDK_memA PF04696.13 CDI84325.1 - 6.5 6.8 40.8 7.6 6.6 12.9 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region CRT10 PF08728.10 CDI84325.1 - 6.7 4.7 18.6 8.1 4.5 18.6 1.0 1 0 0 1 1 1 0 CRT10 RskA PF10099.9 CDI84328.1 - 0.0046 17.3 10.1 0.005 17.2 10.1 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI84328.1 - 0.019 15.9 4.8 0.02 15.8 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TFIIA PF03153.13 CDI84328.1 - 0.044 13.8 24.8 0.043 13.8 24.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.19 CDI84328.1 - 0.048 14.3 1.8 0.048 14.3 1.8 1.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Spt20 PF12090.8 CDI84328.1 - 0.052 13.2 28.4 0.055 13.1 28.4 1.2 1 0 0 1 1 1 0 Spt20 family PigN PF04987.14 CDI84328.1 - 0.056 12.3 1.2 0.059 12.2 1.2 1.0 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Suf PF05843.14 CDI84328.1 - 0.076 13.0 9.6 0.067 13.2 9.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF1980 PF09323.10 CDI84328.1 - 0.097 12.6 2.4 0.11 12.5 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Glt_symporter PF03616.14 CDI84328.1 - 0.12 11.0 0.9 0.14 10.9 0.9 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter Presenilin PF01080.17 CDI84328.1 - 0.36 9.5 7.3 0.4 9.4 7.3 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 CDI84328.1 - 0.44 9.3 6.7 0.47 9.2 6.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter NEMP PF10225.9 CDI84328.1 - 0.44 10.2 2.8 0.48 10.0 2.8 1.1 1 0 0 1 1 1 0 NEMP family Neur_chan_memb PF02932.16 CDI84328.1 - 0.46 10.5 3.2 0.48 10.5 3.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Serinc PF03348.15 CDI84328.1 - 0.59 9.0 3.9 0.63 8.9 3.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RRM PF10378.9 CDI84328.1 - 0.99 9.2 9.7 3.2 7.5 9.7 1.9 1 0 0 1 1 1 0 Putative RRM domain DUF1180 PF06679.12 CDI84328.1 - 1.1 9.6 9.0 1.4 9.3 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) R_equi_Vir PF05526.11 CDI84328.1 - 1.2 9.0 5.9 1.4 8.8 5.9 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Pex14_N PF04695.13 CDI84328.1 - 1.4 9.5 18.0 1.9 9.1 18.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM199X PF15814.5 CDI84328.1 - 6.5 5.7 9.6 7.3 5.5 9.6 1.1 1 0 0 1 1 1 0 Protein family FAM199X Dehydrin PF00257.19 CDI84331.1 - 0.033 14.7 5.1 0.033 14.7 5.1 2.9 1 1 2 3 3 3 0 Dehydrin Macoilin PF09726.9 CDI84331.1 - 2.1 6.8 12.7 2.7 6.5 12.7 1.1 1 0 0 1 1 1 0 Macoilin family Spt20 PF12090.8 CDI84331.1 - 2.6 7.6 9.7 4.1 7.0 9.7 1.3 1 0 0 1 1 1 0 Spt20 family Menin PF05053.13 CDI84331.1 - 4.8 5.4 19.1 6 5.1 19.1 1.0 1 0 0 1 1 1 0 Menin BRF1 PF07741.13 CDI84331.1 - 6.9 7.1 9.1 0.66 10.4 3.6 1.9 1 1 1 2 2 2 0 Brf1-like TBP-binding domain SR-25 PF10500.9 CDI84331.1 - 8.2 6.0 20.9 9 5.8 19.7 1.7 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein DUF1746 PF08508.10 CDI84338.1 - 0.0066 16.8 0.9 2 8.8 0.0 3.0 2 1 1 3 3 3 1 Fungal domain of unknown function (DUF1746) TMEM100 PF16311.5 CDI84338.1 - 0.016 14.8 2.7 2.9 7.5 1.0 2.6 2 1 0 2 2 2 0 Transmembrane protein 100 zf-C3H1 PF10650.9 CDI84338.1 - 0.27 11.0 1.4 27 4.6 0.2 2.8 2 0 0 2 2 2 0 Putative zinc-finger domain DUF2953 PF11167.8 CDI84338.1 - 0.66 10.1 5.5 32 4.7 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2953) Thioredoxin PF00085.20 CDI84346.1 - 8.4e-29 99.6 0.3 9.3e-29 99.5 0.3 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CDI84346.1 - 0.00011 22.6 0.3 0.0015 19.0 0.3 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 CDI84346.1 - 0.00019 21.2 0.1 0.00019 21.2 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Glutaredoxin PF00462.24 CDI84346.1 - 0.00021 21.4 0.1 0.00035 20.7 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_8 PF13905.6 CDI84346.1 - 0.0011 19.2 0.0 0.0019 18.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like KaiB PF07689.12 CDI84346.1 - 0.0027 17.4 0.0 0.0046 16.7 0.0 1.5 2 0 0 2 2 2 1 KaiB domain OST3_OST6 PF04756.13 CDI84346.1 - 0.061 12.7 0.1 0.069 12.5 0.1 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 CDI84346.1 - 0.074 13.2 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like Redoxin PF08534.10 CDI84346.1 - 0.079 12.7 0.8 0.5 10.1 0.2 2.0 1 1 1 2 2 2 0 Redoxin RskA PF10099.9 CDI84356.1 - 0.00023 21.5 0.5 0.0004 20.7 0.5 1.4 1 1 0 1 1 1 1 Anti-sigma-K factor rskA ECM1 PF05782.11 CDI84356.1 - 0.1 11.5 18.9 0.11 11.4 18.9 1.0 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) SR-25 PF10500.9 CDI84356.1 - 0.18 11.4 38.1 0.53 9.9 38.1 1.7 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein SprA-related PF12118.8 CDI84356.1 - 1.9 7.6 35.6 2.2 7.3 35.6 1.1 1 0 0 1 1 1 0 SprA-related family Herpes_pp85 PF04637.12 CDI84356.1 - 3.1 6.1 15.3 3.7 5.9 15.3 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) PA26 PF04636.13 CDI84356.1 - 7.3 5.4 13.9 7.2 5.4 13.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4179 PF13786.6 CDI84357.1 - 0.039 14.4 1.1 1 9.8 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) DUF1631 PF07793.11 CDI84357.1 - 0.15 10.5 32.6 0.17 10.2 32.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) SLC12 PF03522.15 CDI84357.1 - 0.2 10.6 16.9 0.3 10.1 16.9 1.3 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI84357.1 - 0.73 8.0 33.3 0.91 7.7 33.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF572 PF04502.13 CDI84357.1 - 0.81 9.2 16.8 1.2 8.7 16.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) RED_N PF07808.13 CDI84357.1 - 0.84 9.2 23.0 0.41 10.2 0.3 2.1 2 0 0 2 2 2 0 RED-like protein N-terminal region UPF0564 PF10595.9 CDI84357.1 - 0.96 8.4 27.4 0.14 11.2 14.5 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0564 FAM176 PF14851.6 CDI84357.1 - 1.1 8.9 10.6 0.71 9.5 5.4 2.2 2 0 0 2 2 2 0 FAM176 family O-antigen_lig PF13425.6 CDI84357.1 - 1.2 7.8 7.0 0.097 11.4 1.5 1.7 2 0 0 2 2 2 0 O-antigen ligase like membrane protein SWI-SNF_Ssr4 PF08549.10 CDI84357.1 - 1.3 7.6 24.3 1.6 7.3 24.3 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) MDM10 PF12519.8 CDI84357.1 - 1.4 7.7 14.9 2.1 7.1 14.9 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CobT PF06213.12 CDI84357.1 - 1.6 8.0 29.8 1.9 7.8 18.8 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Rtf2 PF04641.12 CDI84357.1 - 1.7 7.9 19.0 0.76 9.1 10.3 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger DUF4207 PF13904.6 CDI84357.1 - 1.8 8.2 37.6 2.7 7.6 37.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) DUF2072 PF09845.9 CDI84357.1 - 4.9 7.4 14.0 11 6.2 0.1 2.2 2 0 0 2 2 2 0 Zn-ribbon containing protein SRP-alpha_N PF04086.13 CDI84357.1 - 5.9 6.7 22.9 8.2 6.3 22.9 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CTC1_2 PF15491.6 CDI84357.1 - 6.2 6.0 5.4 9.3 5.5 5.4 1.3 1 1 0 1 1 1 0 CST, telomere maintenance, complex subunit CTC1 Ndc1_Nup PF09531.10 CDI84357.1 - 6.2 5.4 21.2 7.8 5.1 21.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DDRGK PF09756.9 CDI84357.1 - 8.5 5.9 26.4 4.4 6.9 15.8 2.1 2 0 0 2 2 2 0 DDRGK domain DREPP PF05558.12 CDI84357.1 - 9.1 6.1 12.3 46 3.8 11.2 2.0 2 0 0 2 2 2 0 DREPP plasma membrane polypeptide Connexin PF00029.19 CDI84360.1 - 0.097 12.4 16.4 0.11 12.3 16.4 1.0 1 0 0 1 1 1 0 Connexin MCD PF05292.11 CDI84360.1 - 0.27 10.8 7.8 0.3 10.6 7.8 1.0 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain DUF5308 PF17233.2 CDI84360.1 - 0.58 10.4 2.7 0.59 10.3 2.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Pinin_SDK_memA PF04696.13 CDI84360.1 - 0.66 10.0 30.1 0.81 9.7 30.1 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region Serinc PF03348.15 CDI84360.1 - 0.72 8.7 6.5 0.83 8.5 6.5 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) FAM176 PF14851.6 CDI84360.1 - 0.78 9.4 7.9 0.95 9.1 7.9 1.1 1 0 0 1 1 1 0 FAM176 family PDCD7 PF16021.5 CDI84360.1 - 1.2 8.2 27.1 1.2 8.2 27.1 1.0 1 0 0 1 1 1 0 Programmed cell death protein 7 Ureide_permease PF07168.11 CDI84360.1 - 1.2 7.8 10.2 1.3 7.7 10.2 1.0 1 0 0 1 1 1 0 Ureide permease Tim54 PF11711.8 CDI84360.1 - 1.3 7.8 17.4 1.4 7.7 17.4 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AAA_23 PF13476.6 CDI84360.1 - 1.5 9.2 29.1 1.7 9.1 29.1 1.0 1 0 0 1 1 1 0 AAA domain SpoIIP PF07454.11 CDI84360.1 - 1.7 8.0 19.8 1.8 7.9 19.8 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) EMC3_TMCO1 PF01956.16 CDI84360.1 - 1.8 8.3 21.9 2.3 7.9 21.9 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like NPR3 PF03666.13 CDI84360.1 - 1.8 7.3 17.6 2 7.1 17.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CSG2 PF16965.5 CDI84360.1 - 2 7.3 9.2 1.9 7.3 9.2 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator V_ATPase_I PF01496.19 CDI84360.1 - 2.2 6.1 15.1 2.1 6.2 15.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_11 PF13086.6 CDI84360.1 - 2.2 8.0 20.1 2.3 7.9 20.1 1.0 1 0 0 1 1 1 0 AAA domain RPN2_C PF18004.1 CDI84360.1 - 2.3 8.1 35.0 2.7 7.9 35.0 1.0 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain RR_TM4-6 PF06459.12 CDI84360.1 - 2.3 8.0 23.2 2.5 7.9 23.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CLN3 PF02487.17 CDI84360.1 - 2.6 7.0 10.0 2.7 6.9 10.0 1.0 1 0 0 1 1 1 0 CLN3 protein SID-1_RNA_chan PF13965.6 CDI84360.1 - 2.9 6.2 8.9 3.1 6.1 8.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Folliculin PF11704.8 CDI84360.1 - 3 7.7 10.3 3 7.7 10.3 1.0 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport RP-C_C PF11800.8 CDI84360.1 - 3.2 7.8 9.2 3.8 7.6 9.2 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region Zip PF02535.22 CDI84360.1 - 3.6 6.7 9.7 4.1 6.5 9.7 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Vfa1 PF08432.10 CDI84360.1 - 3.8 7.8 31.5 4.4 7.6 31.5 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 EOS1 PF12326.8 CDI84360.1 - 4.4 7.2 9.7 4.8 7.1 9.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein DDHD PF02862.17 CDI84360.1 - 4.7 7.3 10.2 5.5 7.1 10.2 1.2 1 0 0 1 1 1 0 DDHD domain DUF4446 PF14584.6 CDI84360.1 - 4.9 7.1 16.1 5 7.1 16.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) RNA_pol_Rpc4 PF05132.14 CDI84360.1 - 5.3 7.5 18.3 6.4 7.2 18.3 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF2828 PF11443.8 CDI84360.1 - 5.8 4.9 19.8 6.4 4.7 19.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) O-antigen_lig PF13425.6 CDI84360.1 - 6.1 5.5 19.1 6.7 5.4 19.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Nucleoside_tran PF01733.18 CDI84360.1 - 6.1 6.1 6.3 6.5 6.0 6.3 1.0 1 0 0 1 1 1 0 Nucleoside transporter DUF1003 PF06210.11 CDI84360.1 - 6.2 7.0 6.7 41 4.3 6.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1003) AIF_C PF14721.6 CDI84360.1 - 6.7 7.1 13.6 8.5 6.7 13.6 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Tfb4 PF03850.14 CDI84360.1 - 6.9 6.1 9.1 7.4 6.0 9.1 1.0 1 0 0 1 1 1 0 Transcription factor Tfb4 LicD PF04991.13 CDI84360.1 - 7.1 6.7 21.7 7.7 6.6 21.7 1.0 1 0 0 1 1 1 0 LicD family FemAB PF02388.16 CDI84360.1 - 7.9 5.2 22.3 8.9 5.1 22.3 1.0 1 0 0 1 1 1 0 FemAB family DUF2126 PF09899.9 CDI84360.1 - 8 4.4 8.9 8.1 4.4 8.9 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) OATP PF03137.20 CDI84360.1 - 9.3 4.4 11.3 9.4 4.4 11.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Peroxin-13_N PF04088.13 CDI84360.1 - 9.5 6.5 13.4 11 6.3 13.4 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF5401 PF17380.2 CDI84360.1 - 9.8 4.1 26.5 12 3.8 26.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) zf-rbx1 PF12678.7 CDI84364.1 - 0.00017 21.8 3.4 0.00017 21.8 3.4 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDI84364.1 - 0.00028 20.9 2.2 0.00028 20.9 2.2 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger TFIIA PF03153.13 CDI84364.1 - 0.0083 16.2 44.0 0.011 15.8 44.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Utp14 PF04615.13 CDI84364.1 - 0.9 8.0 33.0 1.2 7.7 33.0 1.1 1 0 0 1 1 1 0 Utp14 protein DUF572 PF04502.13 CDI84364.1 - 3.8 7.1 39.0 5.6 6.5 39.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Glt_symporter PF03616.14 CDI84364.1 - 4.5 5.9 4.8 6.2 5.4 4.8 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter PAT1 PF09770.9 CDI84364.1 - 8.5 4.5 30.6 10 4.3 30.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2722 PF10846.8 CDI84370.1 - 7.1e-06 25.2 0.4 0.0021 17.1 3.9 9.0 4 2 4 8 8 8 3 Protein of unknown function (DUF2722) AMP-binding PF00501.28 CDI84370.1 - 0.26 9.8 9.2 0.64 8.5 4.0 3.0 2 0 0 2 2 2 0 AMP-binding enzyme Kei1 PF08552.11 CDI84378.1 - 0.03 14.2 0.2 0.042 13.7 0.2 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 CCD48 PF15799.5 CDI84378.1 - 0.096 11.0 7.9 0.13 10.5 7.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 Tic110 PF16940.5 CDI84378.1 - 0.37 9.2 7.3 0.46 8.9 7.3 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter SAPS PF04499.15 CDI84389.1 - 9.6 4.9 18.0 13 4.4 18.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TFIIA PF03153.13 CDI84391.1 - 1.9e-05 24.9 61.6 5.4e-05 23.4 25.7 2.4 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit DUF4647 PF15504.6 CDI84391.1 - 0.0016 17.6 25.1 0.028 13.6 5.8 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4647) Presenilin PF01080.17 CDI84391.1 - 0.0031 16.4 8.2 0.0031 16.4 8.2 2.3 2 0 0 2 2 2 1 Presenilin DUF4746 PF15928.5 CDI84391.1 - 0.0033 16.9 5.4 0.0033 16.9 5.4 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4746) Ribosomal_60s PF00428.19 CDI84391.1 - 0.0035 17.9 4.8 0.0035 17.9 4.8 5.5 4 1 0 4 4 3 1 60s Acidic ribosomal protein SID-1_RNA_chan PF13965.6 CDI84391.1 - 0.0041 15.6 4.1 0.0064 15.0 0.4 2.0 2 0 0 2 2 2 1 dsRNA-gated channel SID-1 PNISR PF15996.5 CDI84391.1 - 0.0042 17.4 7.5 0.0042 17.4 7.5 2.7 3 0 0 3 3 2 1 Arginine/serine-rich protein PNISR DUF5523 PF17661.1 CDI84391.1 - 0.0088 15.8 8.7 0.0088 15.8 8.7 2.3 2 0 0 2 2 2 1 Family of unknown function (DUF5523) DUF2072 PF09845.9 CDI84391.1 - 0.052 13.8 15.6 0.026 14.8 7.7 2.5 2 0 0 2 2 2 0 Zn-ribbon containing protein DUF2052 PF09747.9 CDI84391.1 - 0.058 13.5 21.0 0.18 11.9 8.3 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SpoIIP PF07454.11 CDI84391.1 - 0.1 12.0 19.0 0.019 14.5 8.2 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF572 PF04502.13 CDI84391.1 - 0.15 11.7 21.1 0.47 10.0 10.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) CNDH2_C PF16858.5 CDI84391.1 - 0.16 11.9 19.0 0.025 14.5 7.3 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term EPL1 PF10513.9 CDI84391.1 - 0.16 12.4 20.7 0.13 12.6 7.5 2.7 2 0 0 2 2 2 0 Enhancer of polycomb-like Connexin PF00029.19 CDI84391.1 - 0.18 11.5 14.1 0.11 12.3 6.5 2.2 2 0 0 2 2 2 0 Connexin RskA PF10099.9 CDI84391.1 - 0.21 11.9 60.2 0.018 15.3 11.3 4.9 2 1 2 4 4 4 0 Anti-sigma-K factor rskA FAM60A PF15396.6 CDI84391.1 - 0.24 11.4 13.2 0.099 12.6 2.7 2.5 2 0 0 2 2 2 0 Protein Family FAM60A DUF3807 PF12720.7 CDI84391.1 - 0.28 11.5 28.4 0.016 15.5 9.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) DUF1387 PF07139.11 CDI84391.1 - 0.29 10.8 20.0 0.39 10.4 7.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) MDM10 PF12519.8 CDI84391.1 - 0.32 9.8 13.0 0.027 13.3 3.1 2.2 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 HNOBA PF07701.14 CDI84391.1 - 0.34 10.3 11.7 0.039 13.4 2.0 2.4 2 0 0 2 2 2 0 Heme NO binding associated DUF2828 PF11443.8 CDI84391.1 - 0.37 8.8 16.1 0.24 9.5 6.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Peptidase_U57 PF05582.12 CDI84391.1 - 0.47 9.7 14.0 0.049 12.9 6.3 2.1 2 0 0 2 2 2 0 YabG peptidase U57 Afi1 PF07792.12 CDI84391.1 - 0.53 10.8 19.5 0.42 11.1 11.2 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking eIF-3_zeta PF05091.12 CDI84391.1 - 0.56 9.1 24.9 0.095 11.7 12.1 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PPP4R2 PF09184.11 CDI84391.1 - 0.61 9.6 10.4 0.13 11.8 3.8 2.2 2 0 0 2 2 2 0 PPP4R2 DUF1980 PF09323.10 CDI84391.1 - 0.62 10.0 13.7 0.66 9.9 7.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) FAM76 PF16046.5 CDI84391.1 - 0.76 9.1 21.2 0.11 11.9 8.5 2.2 2 0 0 2 2 2 0 FAM76 protein Tfb4 PF03850.14 CDI84391.1 - 0.99 8.8 13.6 0.56 9.6 5.7 2.4 2 0 0 2 2 2 0 Transcription factor Tfb4 FAM91_C PF14648.6 CDI84391.1 - 1.4 7.7 10.7 0.083 11.7 2.2 2.1 2 0 0 2 2 2 0 FAM91 C-terminus DUF4820 PF16091.5 CDI84391.1 - 1.4 8.2 16.4 2.6 7.4 8.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) ABC2_membrane_2 PF12679.7 CDI84391.1 - 1.9 7.7 7.7 0.12 11.6 1.4 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein FAM176 PF14851.6 CDI84391.1 - 2.8 7.6 15.0 1.1 8.9 8.3 2.4 2 0 0 2 2 2 0 FAM176 family DUF4471 PF14740.6 CDI84391.1 - 3 7.0 11.7 0.24 10.6 4.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) V_ATPase_I PF01496.19 CDI84391.1 - 3.3 5.5 24.4 0.19 9.6 12.1 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family GPCR_chapero_1 PF11904.8 CDI84391.1 - 3.6 6.9 15.1 1.5 8.2 5.5 2.2 2 0 0 2 2 2 0 GPCR-chaperone VIR_N PF15912.5 CDI84391.1 - 4.6 6.8 9.3 0.72 9.4 3.1 2.1 2 0 0 2 2 2 0 Virilizer, N-terminal CLN3 PF02487.17 CDI84391.1 - 5.5 5.9 20.1 0.16 11.0 5.9 2.9 3 0 0 3 3 3 0 CLN3 protein Eapp_C PF10238.9 CDI84391.1 - 5.9 7.0 24.6 0.086 12.9 8.2 2.8 3 0 0 3 3 2 0 E2F-associated phosphoprotein GET2 PF08690.10 CDI84391.1 - 6.2 6.4 26.4 1.7 8.2 8.6 2.4 2 0 0 2 2 2 0 GET complex subunit GET2 PPL5 PF18168.1 CDI84391.1 - 6.4 6.0 16.3 0.51 9.6 7.4 2.3 2 0 0 2 2 2 0 Prim-pol family 5 OATP PF03137.20 CDI84391.1 - 6.6 4.9 10.6 4 5.6 4.5 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Membralin PF09746.9 CDI84391.1 - 6.6 5.7 14.5 0.62 9.0 6.0 2.1 2 0 0 2 2 2 0 Tumour-associated protein Ureide_permease PF07168.11 CDI84391.1 - 6.8 5.3 11.4 3.8 6.2 5.8 2.4 2 0 0 2 2 2 0 Ureide permease PAT1 PF09770.9 CDI84391.1 - 7 4.8 47.0 0.13 10.5 16.4 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF4366 PF14283.6 CDI84391.1 - 8 6.5 17.3 0.31 11.1 5.3 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) SpoVR PF04293.13 CDI84391.1 - 9 4.9 15.8 3.1 6.4 7.4 2.1 2 0 0 2 2 2 0 SpoVR like protein DUF913 PF06025.12 CDI84391.1 - 9.8 5.0 16.5 0.85 8.5 6.5 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 CDI84393.1 - 7.8e-05 21.6 1.0 7.8e-05 21.6 1.0 6.8 4 1 1 6 6 6 1 Presenilin DUF2722 PF10846.8 CDI84393.1 - 0.0034 16.4 6.9 0.0034 16.4 6.9 8.3 6 1 1 7 7 7 3 Protein of unknown function (DUF2722) Ribosomal_60s PF00428.19 CDI84393.1 - 0.013 16.0 1.5 0.013 16.0 1.5 8.1 6 2 0 6 6 6 0 60s Acidic ribosomal protein Spore_YhcN_YlaJ PF09580.10 CDI84393.1 - 0.048 13.7 0.0 0.048 13.7 0.0 4.5 2 2 1 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) PAP1 PF08601.10 CDI84393.1 - 0.33 10.6 0.0 0.33 10.6 0.0 8.5 7 2 1 8 8 8 0 Transcription factor PAP1 VPS13 PF16908.5 CDI84394.1 - 1.4e-17 64.3 0.0 1e-14 54.9 0.0 2.3 2 0 0 2 2 2 2 Vacuolar sorting-associated protein 13, N-terminal MTES_1575 PF18741.1 CDI84394.1 - 0.45 10.7 5.6 0.81 9.9 0.8 2.7 2 1 1 3 3 3 0 REase_MTES_1575 DUF4834 PF16118.5 CDI84394.1 - 6.2 7.8 8.1 37 5.3 5.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ribosomal_L11_N PF03946.14 CDI84395.1 - 2.4e-21 75.3 0.1 3.5e-21 74.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CDI84395.1 - 1.5e-17 63.9 0.2 2.4e-17 63.2 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain gerPA PF10676.9 CDI84395.1 - 0.087 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Spore germination protein gerPA/gerPF Ribosomal_L30 PF00327.20 CDI84396.1 - 2e-14 53.2 0.7 3.7e-14 52.3 0.7 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 CDI84396.1 - 6.9e-13 48.7 16.2 6.9e-13 48.7 16.2 1.8 2 0 0 2 2 2 1 Ribosomal L30 N-terminal domain Ribosomal_S8e PF01201.22 CDI84396.1 - 0.006 16.8 0.9 0.0085 16.3 0.9 1.3 1 0 0 1 1 1 1 Ribosomal protein S8e PGC7_Stella PF15549.6 CDI84396.1 - 0.22 11.5 2.4 0.44 10.5 2.4 1.4 1 0 0 1 1 1 0 PGC7/Stella/Dppa3 domain Steroid_dh PF02544.16 CDI84397.1 - 7.4e-10 39.0 1.2 2.6e-06 27.5 0.0 3.3 4 0 0 4 4 4 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF2722 PF10846.8 CDI84397.1 - 1.4e-06 27.5 5.8 0.048 12.6 0.0 2.2 2 1 0 2 2 2 2 Protein of unknown function (DUF2722) Ctr PF04145.15 CDI84397.1 - 0.0049 17.5 0.5 0.026 15.1 0.8 1.9 2 0 0 2 2 2 1 Ctr copper transporter family MARVEL PF01284.23 CDI84397.1 - 0.015 15.3 7.3 18 5.4 0.0 3.3 2 1 1 3 3 3 0 Membrane-associating domain PAPA-1 PF04795.12 CDI84397.1 - 0.041 14.7 1.4 0.041 14.7 1.4 2.1 2 0 0 2 2 2 0 PAPA-1-like conserved region Presenilin PF01080.17 CDI84397.1 - 0.12 11.1 1.9 0.19 10.4 1.9 1.3 1 0 0 1 1 1 0 Presenilin GWT1 PF06423.12 CDI84397.1 - 0.18 11.9 2.0 0.77 9.9 0.6 2.2 2 0 0 2 2 2 0 GWT1 DUF4834 PF16118.5 CDI84397.1 - 0.25 12.3 0.1 0.25 12.3 0.1 2.8 3 1 0 3 3 2 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 CDI84397.1 - 0.8 10.6 7.3 14 6.6 0.3 2.9 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain dsDNA_bind PF01984.20 CDI84397.1 - 1.1 9.6 17.7 3.6 7.9 1.2 2.2 2 0 0 2 2 2 0 Double-stranded DNA-binding domain DUF533 PF04391.12 CDI84397.1 - 1.2 8.7 9.0 11 5.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF533) Suf PF05843.14 CDI84397.1 - 1.7 8.6 10.5 2.3 8.1 3.1 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF2489 PF10675.9 CDI84397.1 - 9.6 6.1 15.4 3.9 7.4 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) DTC PF18102.1 CDI84399.1 - 1.6e-43 148.0 0.0 2.7e-43 147.3 0.0 1.4 1 0 0 1 1 1 1 Deltex C-terminal domain WWE PF02825.20 CDI84399.1 - 6.1e-09 36.4 4.8 2.6e-05 24.7 0.0 2.6 2 0 0 2 2 2 2 WWE domain zf-RING_2 PF13639.6 CDI84399.1 - 8e-05 22.9 4.8 8e-05 22.9 4.8 3.1 3 0 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.5 CDI84399.1 - 0.00076 19.2 6.9 0.046 13.5 2.1 2.8 2 0 0 2 2 2 2 RING-like zinc finger zf-rbx1 PF12678.7 CDI84399.1 - 0.0025 18.1 8.2 0.003 17.8 4.2 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CDI84399.1 - 0.0052 16.6 8.4 0.008 16.0 3.8 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 CDI84399.1 - 0.015 15.2 2.3 0.015 15.2 2.3 2.8 4 0 0 4 4 4 0 PHD-finger zf-RING_UBOX PF13445.6 CDI84399.1 - 0.022 14.8 6.3 0.093 12.8 2.5 2.8 2 0 0 2 2 2 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 CDI84399.1 - 0.053 13.6 1.6 0.39 10.8 1.1 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger YcgL PF05166.13 CDI84399.1 - 0.13 12.6 0.1 0.3 11.5 0.1 1.5 1 0 0 1 1 1 0 YcgL domain zf-C3HC4_2 PF13923.6 CDI84399.1 - 0.24 11.3 10.6 0.37 10.7 6.2 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI84399.1 - 0.76 9.8 8.6 0.27 11.2 3.1 2.8 3 0 0 3 3 3 0 zinc-RING finger domain Ribosomal_S19e PF01090.19 CDI84400.1 - 2.1e-51 173.2 0.0 2.3e-51 173.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e HTH_12 PF08461.10 CDI84400.1 - 0.00088 19.2 0.1 0.002 18.1 0.1 1.6 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain MarR_2 PF12802.7 CDI84400.1 - 0.095 12.6 0.0 0.56 10.1 0.0 2.2 3 0 0 3 3 3 0 MarR family AP_endonuc_2 PF01261.24 CDI84401.1 - 1.7e-29 102.8 0.0 2.4e-29 102.3 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel CDK2AP PF09806.9 CDI84401.1 - 2 8.4 6.5 2.3 8.2 4.5 1.8 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein DUF2052 PF09747.9 CDI84401.1 - 2.2 8.4 9.0 9.9 6.2 5.9 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) ABC1 PF03109.16 CDI84402.1 - 4e-32 110.9 0.0 8.5e-32 109.8 0.0 1.5 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 CDI84402.1 - 0.026 14.1 0.0 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 CDI84402.1 - 0.6 10.0 5.4 0.54 10.1 0.2 3.1 3 1 1 4 4 4 0 Phosphotransferase enzyme family Ribonuc_P_40 PF08584.11 CDI84405.1 - 0.00021 20.7 0.0 0.0028 17.0 0.0 2.1 2 0 0 2 2 2 1 Ribonuclease P 40kDa (Rpp40) subunit Oxygenase-NA PF09859.9 CDI84405.1 - 0.15 11.6 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA SbcCD_C PF13558.6 CDI84406.1 - 3.4e-06 27.2 0.0 9.5e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Metallophos PF00149.28 CDI84406.1 - 1.7e-05 25.5 0.0 3.8e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase AAA_21 PF13304.6 CDI84406.1 - 0.00068 19.5 0.1 0.0014 18.5 0.1 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system DAOA PF15199.6 CDI84406.1 - 0.17 12.3 0.0 1.6 9.2 0.0 2.3 2 0 0 2 2 2 0 D-amino acid oxidase activator TPR_2 PF07719.17 CDI84407.1 - 2.8e-14 52.0 4.9 0.0019 18.1 0.0 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDI84407.1 - 9.1e-12 44.3 4.4 0.00046 19.9 0.0 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI84407.1 - 2.1e-10 40.5 1.5 0.071 14.0 0.2 4.6 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDI84407.1 - 2.6e-10 39.6 0.0 0.084 13.1 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDI84407.1 - 1e-08 34.6 0.2 0.028 14.4 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDI84407.1 - 3.2e-07 30.6 0.3 0.44 11.3 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDI84407.1 - 3.5e-07 30.1 0.0 2.3 8.8 0.0 4.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDI84407.1 - 1.6e-06 28.5 0.5 0.12 12.9 0.0 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDI84407.1 - 1.7e-06 28.0 3.4 0.0052 16.9 0.5 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDI84407.1 - 8.2e-05 22.8 1.2 0.93 9.8 0.0 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_15 PF13429.6 CDI84407.1 - 0.00071 18.9 0.1 0.0026 17.0 0.1 2.2 1 1 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI84407.1 - 0.00073 19.7 1.3 0.26 11.5 0.2 3.0 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CDI84407.1 - 0.0033 17.1 0.0 17 5.2 0.0 4.0 3 2 1 4 4 4 0 TPR repeat TPR_16 PF13432.6 CDI84407.1 - 0.004 17.8 0.9 0.78 10.4 0.0 3.7 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 CDI84407.1 - 0.054 13.4 2.1 3.5 7.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Peptidase_M14 PF00246.24 CDI84417.1 - 1.4e-10 41.4 0.0 2.3e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 CDI84417.1 - 0.027 13.6 0.0 0.053 12.6 0.0 1.5 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family AP3D1 PF06375.11 CDI84418.1 - 0.0046 17.2 4.6 0.0066 16.7 4.6 1.2 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 DUF2046 PF09755.9 CDI84418.1 - 0.039 13.2 8.7 0.057 12.7 8.7 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Rrn6 PF10214.9 CDI84418.1 - 0.067 11.7 4.3 0.063 11.8 4.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF4047 PF13256.6 CDI84418.1 - 0.082 13.1 0.6 0.11 12.6 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) ORC3_N PF07034.11 CDI84418.1 - 2.1 7.3 5.3 2.9 6.9 5.3 1.1 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus UCR_TM PF02921.14 CDI84429.1 - 0.6 10.6 0.1 0.6 10.6 0.1 2.5 2 1 0 2 2 2 0 Ubiquinol cytochrome reductase transmembrane region Auxin_canalis PF05703.11 CDI84429.1 - 0.81 9.6 29.3 0.92 9.4 29.3 1.0 1 0 0 1 1 1 0 Auxin canalisation CDC45 PF02724.14 CDI84429.1 - 7.2 4.8 42.9 9.2 4.4 42.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 CDI84429.1 - 9.2 4.3 47.9 11 4.0 47.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF572 PF04502.13 CDI84433.1 - 0.93 9.1 56.8 1.3 8.6 56.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) AAA_30 PF13604.6 CDI84447.1 - 7.9e-06 25.7 2.1 9.5e-06 25.5 2.1 1.1 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CDI84447.1 - 1.7e-05 24.4 0.0 3.3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 CDI84447.1 - 0.00024 21.5 0.5 0.00039 20.8 0.4 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 CDI84447.1 - 0.0015 18.9 0.0 0.0016 18.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CDI84447.1 - 0.0073 15.4 0.0 0.0099 15.0 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF815 PF05673.13 CDI84447.1 - 0.015 14.5 0.2 0.022 13.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF853 PF05872.12 CDI84447.1 - 0.016 13.8 0.8 0.016 13.8 0.8 1.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) Sigma54_activat PF00158.26 CDI84447.1 - 0.036 13.8 0.1 0.051 13.3 0.1 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 CDI84447.1 - 0.07 12.8 1.6 0.076 12.7 0.1 1.8 1 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 CDI84447.1 - 0.098 12.9 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 CDI84447.1 - 0.11 12.4 0.5 0.17 11.8 0.5 1.4 1 0 0 1 1 1 0 Helicase DUF87 PF01935.17 CDI84447.1 - 0.19 11.8 0.2 0.19 11.8 0.2 1.8 2 0 0 2 2 2 0 Helicase HerA, central domain Menin PF05053.13 CDI84447.1 - 0.3 9.4 19.5 0.34 9.2 19.5 1.0 1 0 0 1 1 1 0 Menin SLC12 PF03522.15 CDI84447.1 - 2 7.4 5.1 2.1 7.3 5.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 ORC6 PF05460.13 CDI84447.1 - 3.2 6.9 15.7 3.8 6.7 15.7 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Apt1 PF10351.9 CDI84447.1 - 4.5 6.0 21.3 6.5 5.5 21.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Silic_transp PF03842.13 CDI84450.1 - 2 6.7 9.2 0.49 8.6 6.4 1.3 1 1 0 1 1 1 0 Silicon transporter Utp14 PF04615.13 CDI84450.1 - 9.5 4.7 47.9 12 4.3 47.9 1.1 1 0 0 1 1 1 0 Utp14 protein TFIIA PF03153.13 CDI84461.1 - 5.2 7.0 71.4 7.2 6.5 71.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDK5_activator PF03261.15 CDI84470.1 - 1.3 8.5 26.3 1.7 8.1 26.3 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein GREB1 PF15782.5 CDI84470.1 - 1.9 5.5 36.4 2.2 5.3 36.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4776 PF16003.5 CDI84470.1 - 2.4 7.1 34.0 2.7 6.9 34.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) DUF3810 PF12725.7 CDI84470.1 - 5.2 6.3 14.9 8.4 5.6 14.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) DUF4079 PF13301.6 CDI84471.1 - 3.9 7.6 6.8 3.6e+02 1.3 6.8 3.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) RskA PF10099.9 CDI84481.1 - 0.0016 18.8 16.2 0.16 12.2 11.9 2.4 1 1 1 2 2 2 2 Anti-sigma-K factor rskA PPP4R2 PF09184.11 CDI84481.1 - 0.014 15.0 7.4 0.025 14.2 7.4 1.5 1 1 0 1 1 1 0 PPP4R2 TFIIA PF03153.13 CDI84481.1 - 0.029 14.4 12.6 0.044 13.8 12.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LRRC37AB_C PF14914.6 CDI84481.1 - 0.06 13.3 7.4 4 7.3 0.0 2.4 1 1 2 3 3 3 0 LRRC37A/B like protein 1 C-terminal domain K_channel_TID PF07941.11 CDI84481.1 - 0.079 13.4 2.2 0.079 13.4 2.2 4.2 3 1 0 3 3 2 0 Potassium channel Kv1.4 tandem inactivation domain FHIPEP PF00771.20 CDI84481.1 - 0.3 9.5 3.8 0.15 10.5 1.6 1.5 2 0 0 2 2 2 0 FHIPEP family RIFIN PF02009.16 CDI84481.1 - 2.4 8.0 9.5 0.2 11.6 3.6 1.9 2 0 0 2 2 2 0 Rifin DUF4834 PF16118.5 CDI84481.1 - 2.6 9.1 0.0 2.6 9.1 0.0 2.8 2 1 0 2 2 1 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI84481.1 - 8.2 6.0 16.2 3.6 7.1 9.4 2.2 2 0 0 2 2 2 0 Spt20 family Apt1 PF10351.9 CDI84481.1 - 8.3 5.1 23.3 0.32 9.8 7.6 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain DUF572 PF04502.13 CDI84481.1 - 8.4 5.9 15.4 2.2 7.8 5.7 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF572) INCENP_ARK-bind PF03941.15 CDI84496.1 - 1.5e-08 34.4 1.3 1.5e-08 34.4 1.3 4.9 4 0 0 4 4 4 1 Inner centromere protein, ARK binding region SR-25 PF10500.9 CDI84496.1 - 5.6e-06 26.1 8.5 5.6e-06 26.1 8.5 3.9 3 1 1 4 4 4 1 Nuclear RNA-splicing-associated protein TCP PF03634.13 CDI84496.1 - 0.019 15.5 9.3 0.019 15.5 9.3 4.5 3 1 1 4 4 4 0 TCP family transcription factor ANAPC_CDC26 PF10471.9 CDI84499.1 - 0.00042 21.1 31.5 0.027 15.3 7.6 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex APC subunit CDC26 PIP5K PF01504.18 CDI84499.1 - 0.0098 15.1 4.0 0.012 14.9 4.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase ATAD4 PF15321.6 CDI84499.1 - 0.051 14.9 7.2 0.65 11.4 2.2 2.1 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 DUF2828 PF11443.8 CDI84499.1 - 0.058 11.5 8.1 0.074 11.1 8.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) NPR1_interact PF15699.5 CDI84499.1 - 0.068 13.8 9.4 0.9 10.2 0.8 2.2 2 0 0 2 2 2 0 NPR1 interacting DUF572 PF04502.13 CDI84499.1 - 0.089 12.4 10.9 0.13 11.9 10.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Rpp20 PF12328.8 CDI84499.1 - 0.11 12.4 11.0 1.2 9.0 0.5 2.2 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Thg1C PF14413.6 CDI84499.1 - 0.13 12.5 11.6 0.46 10.6 1.0 2.2 2 0 0 2 2 2 0 Thg1 C terminal domain Presenilin PF01080.17 CDI84499.1 - 0.13 11.0 13.9 0.18 10.6 13.9 1.2 1 0 0 1 1 1 0 Presenilin DUF4770 PF15994.5 CDI84499.1 - 0.18 12.1 13.4 0.63 10.3 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) ALMT PF11744.8 CDI84499.1 - 0.23 10.3 7.4 0.26 10.1 7.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter eIF_4EBP PF05456.11 CDI84499.1 - 0.3 11.1 11.2 0.53 10.2 1.2 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) DUF3464 PF11947.8 CDI84499.1 - 0.64 9.8 14.5 0.99 9.1 0.9 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 PTPRCAP PF15713.5 CDI84499.1 - 0.81 10.0 14.9 2.8 8.2 1.1 2.1 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated MPM1 PF17234.2 CDI84499.1 - 0.83 9.9 16.4 2.6 8.3 3.0 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 WBP-1 PF11669.8 CDI84499.1 - 1.3 9.6 10.5 3.1 8.5 1.0 2.3 2 0 0 2 2 2 0 WW domain-binding protein 1 Rad60-SLD_2 PF13881.6 CDI84499.1 - 1.4 9.1 7.3 1.8 8.7 0.5 2.2 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like DUF2076 PF09849.9 CDI84499.1 - 1.5 8.8 35.2 2.2 8.3 35.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) SLC12 PF03522.15 CDI84499.1 - 1.5 7.7 13.0 2 7.4 13.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 WRNPLPNID PF15017.6 CDI84499.1 - 1.7 9.6 10.8 5.9 7.9 1.4 2.3 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box SPG4 PF17325.2 CDI84499.1 - 2 9.5 9.5 9.2 7.4 2.7 2.2 2 0 0 2 2 2 0 Stationary phase protein 4 O-antigen_lig PF13425.6 CDI84499.1 - 2.2 7.0 4.3 2.8 6.6 4.3 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein EphA2_TM PF14575.6 CDI84499.1 - 2.3 9.1 11.3 7.5 7.5 2.4 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Orf78 PF06024.12 CDI84499.1 - 2.6 8.4 8.0 13 6.1 0.3 2.2 2 0 0 2 2 2 0 Orf78 (ac78) dsDNA_bind PF01984.20 CDI84499.1 - 2.7 8.3 35.8 3.7 7.8 13.2 2.2 2 0 0 2 2 2 0 Double-stranded DNA-binding domain CSG2 PF16965.5 CDI84499.1 - 2.9 6.8 6.4 3.8 6.4 6.4 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator TMEM51 PF15345.6 CDI84499.1 - 2.9 7.7 19.2 3.7 7.3 4.9 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 DUF4578 PF15147.6 CDI84499.1 - 3.1 8.7 20.5 6.7 7.6 7.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) PAT1 PF09770.9 CDI84499.1 - 3.3 5.9 26.4 4.1 5.5 26.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BRF1 PF07741.13 CDI84499.1 - 4.1 7.8 17.8 2.4 8.5 1.3 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF3276 PF11680.8 CDI84499.1 - 6 7.0 10.9 6.8 6.8 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3276) CNDH2_M PF16869.5 CDI84499.1 - 6.3 7.5 11.5 9.5 6.9 3.4 2.2 2 0 0 2 2 2 0 PF16858 Glt_symporter PF03616.14 CDI84499.1 - 6.8 5.3 7.3 2.8 6.6 0.9 2.1 2 0 0 2 2 2 0 Sodium/glutamate symporter Conotoxin PF02950.17 CDI84499.1 - 7 7.7 11.0 13 6.9 1.7 2.5 2 0 0 2 2 2 0 Conotoxin Draxin PF15550.6 CDI84499.1 - 7.9 6.3 13.6 11 5.8 13.6 1.1 1 0 0 1 1 1 0 Draxin HAUS4 PF14735.6 CDI84530.1 - 0.17 11.6 0.5 0.26 11.0 0.5 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 DUF3157 PF11355.8 CDI84530.1 - 2.8 7.5 6.8 2.2 7.8 5.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3157) Thiolase_N PF00108.23 CDI84531.1 - 4.4e-33 114.7 0.0 2.8e-22 79.4 0.0 2.0 1 1 1 2 2 2 2 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CDI84531.1 - 1.1e-05 25.1 0.3 0.031 14.1 0.1 2.4 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 CDI84531.1 - 9.3e-05 22.1 2.4 0.0047 16.5 0.6 2.5 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Thiolase_C PF02803.18 CDI84532.1 - 3.4e-26 91.3 0.7 1.4e-25 89.3 0.2 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain Nha1_C PF08619.10 CDI84556.1 - 0.00041 19.7 5.2 0.00069 18.9 5.2 1.3 1 1 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus DUF1645 PF07816.11 CDI84556.1 - 0.001 19.7 5.4 0.014 16.0 2.7 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1645) TCP PF03634.13 CDI84556.1 - 0.0026 18.3 2.4 0.0026 18.3 2.4 2.1 2 0 0 2 2 2 1 TCP family transcription factor SLC12 PF03522.15 CDI84556.1 - 0.0037 16.4 18.8 0.0047 16.0 18.8 1.1 1 0 0 1 1 1 1 Solute carrier family 12 DUF2722 PF10846.8 CDI84556.1 - 0.0098 14.9 26.0 0.0098 14.9 26.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) DUF3675 PF12428.8 CDI84556.1 - 0.015 15.8 5.4 0.015 15.8 5.4 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3675) SpoIIP PF07454.11 CDI84556.1 - 0.017 14.6 14.2 0.43 10.0 7.7 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) CobT PF06213.12 CDI84556.1 - 0.018 14.5 18.0 0.084 12.2 8.7 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT TFB6 PF17110.5 CDI84556.1 - 0.029 14.1 6.3 0.79 9.5 3.5 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF3464 PF11947.8 CDI84556.1 - 0.038 13.7 15.1 0.73 9.6 7.9 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Thg1C PF14413.6 CDI84556.1 - 0.053 13.7 15.9 0.14 12.3 0.3 2.2 2 0 0 2 2 2 0 Thg1 C terminal domain AUX_IAA PF02309.16 CDI84556.1 - 0.06 13.2 7.6 0.092 12.6 7.6 1.2 1 0 0 1 1 1 0 AUX/IAA family AF-4 PF05110.13 CDI84556.1 - 0.076 11.1 24.1 0.011 13.8 11.9 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein 7TM_GPCR_Srw PF10324.9 CDI84556.1 - 0.077 12.3 8.3 0.32 10.2 4.7 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw Rrp15p PF07890.12 CDI84556.1 - 0.09 13.1 16.9 0.99 9.7 2.1 2.2 2 0 0 2 2 2 0 Rrp15p RED_N PF07808.13 CDI84556.1 - 0.1 12.1 24.0 0.17 11.4 12.3 2.1 2 0 0 2 2 2 0 RED-like protein N-terminal region EIIBC-GUT_N PF03612.14 CDI84556.1 - 0.11 12.3 16.6 0.43 10.3 8.1 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus BRF1 PF07741.13 CDI84556.1 - 0.16 12.3 14.9 0.85 10.0 5.7 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain ORC_WH_C PF18137.1 CDI84556.1 - 0.17 11.9 15.0 0.33 11.0 0.1 2.1 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Glyco_transf_22 PF03901.17 CDI84556.1 - 0.2 10.9 5.0 0.085 12.1 2.8 1.5 1 1 0 1 1 1 0 Alg9-like mannosyltransferase family PTPRCAP PF15713.5 CDI84556.1 - 0.31 11.3 15.7 0.1 12.9 3.0 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated TCRP1 PF14944.6 CDI84556.1 - 0.46 10.4 7.0 2.8 7.8 0.1 2.2 2 0 0 2 2 2 0 Tongue Cancer Chemotherapy Resistant Protein 1 Med15 PF09606.10 CDI84556.1 - 0.48 9.1 45.1 1.1 7.9 26.2 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal BAF250_C PF12031.8 CDI84556.1 - 0.66 9.2 13.3 0.72 9.1 3.7 2.2 2 0 0 2 2 2 0 SWI/SNF-like complex subunit BAF250/Osa Peptidase_S64 PF08192.11 CDI84556.1 - 0.94 7.9 18.0 1.2 7.5 18.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 MPM1 PF17234.2 CDI84556.1 - 1.1 9.5 24.5 3.4 7.9 4.9 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Suf PF05843.14 CDI84556.1 - 1.2 9.0 29.1 2 8.3 14.8 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Rpp20 PF12328.8 CDI84556.1 - 1.3 9.0 18.8 0.34 10.9 0.9 2.3 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P MAS20 PF02064.15 CDI84556.1 - 1.8 8.7 21.1 4.1 7.5 9.1 2.3 2 0 0 2 2 2 0 MAS20 protein import receptor DUF3381 PF11861.8 CDI84556.1 - 1.8 8.3 23.8 2.6 7.8 3.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Acatn PF13000.7 CDI84556.1 - 2.1 6.7 11.9 3.4 6.0 11.9 1.3 1 1 0 1 1 1 0 Acetyl-coenzyme A transporter 1 Glt_symporter PF03616.14 CDI84556.1 - 2.2 6.9 9.7 0.78 8.4 2.1 2.1 2 0 0 2 2 2 0 Sodium/glutamate symporter TOM13 PF08219.11 CDI84556.1 - 2.3 8.3 13.2 1.1 9.3 0.1 3.3 2 1 1 3 3 3 0 Outer membrane protein TOM13 CR6_interact PF10147.9 CDI84556.1 - 2.4 7.8 22.7 0.33 10.6 10.3 2.3 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 ATG22 PF11700.8 CDI84556.1 - 2.6 6.6 11.7 0.41 9.2 3.6 2.0 2 0 0 2 2 2 0 Vacuole effluxer Atg22 like Porph_ging PF09697.10 CDI84556.1 - 2.7 8.6 10.1 4.6 7.9 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) DUF808 PF05661.12 CDI84556.1 - 2.9 6.9 6.7 2.7 7.0 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF808) Lin-8 PF03353.15 CDI84556.1 - 2.9 7.3 27.5 0.47 10.0 15.1 2.0 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DcuA_DcuB PF03605.14 CDI84556.1 - 3.1 6.6 15.4 0.028 13.3 4.1 2.0 1 1 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Spore_YhcN_YlaJ PF09580.10 CDI84556.1 - 3.8 7.6 19.9 1.2 9.2 0.1 2.1 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF4050 PF13259.6 CDI84556.1 - 3.9 7.8 19.4 0.14 12.5 0.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4050) MAT1 PF06391.13 CDI84556.1 - 4.3 7.1 32.3 5 6.9 6.7 2.1 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 FlaG PF03646.15 CDI84556.1 - 4.6 7.5 31.6 5.4 7.3 16.2 2.4 2 0 0 2 2 2 0 FlaG protein mRNA_cap_C PF03919.15 CDI84556.1 - 4.8 7.9 9.2 0.76 10.4 2.8 2.0 2 0 0 2 2 2 0 mRNA capping enzyme, C-terminal domain Gaa1 PF04114.14 CDI84556.1 - 6 5.8 18.0 0.36 9.8 6.6 2.0 1 1 1 2 2 2 0 Gaa1-like, GPI transamidase component UPF0560 PF10577.9 CDI84556.1 - 6.1 5.2 34.3 0.76 8.2 16.8 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 ALMT PF11744.8 CDI84556.1 - 6.2 5.5 18.3 4.1 6.1 8.8 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter GDE_N PF12439.8 CDI84556.1 - 6.2 6.2 16.0 0.52 9.7 3.5 2.2 2 0 0 2 2 2 0 Glycogen debranching enzyme N terminal DUF3506 PF12014.8 CDI84556.1 - 8.8 6.3 13.5 9.7 6.2 3.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3506) SR-25 PF10500.9 CDI84557.1 - 0.0057 16.3 17.9 0.0065 16.1 17.9 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI84557.1 - 0.022 15.4 8.3 0.03 15.0 8.3 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein Mem_trans PF03547.18 CDI84557.1 - 4.4 5.6 7.8 4.8 5.5 7.8 1.0 1 0 0 1 1 1 0 Membrane transport protein CDK2AP PF09806.9 CDI84557.1 - 5 7.1 20.5 5.5 7.0 20.5 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein FTZ PF03867.14 CDI84557.1 - 6.6 6.2 16.9 0.28 10.7 11.5 1.4 1 1 1 2 2 2 0 Fushi tarazu (FTZ), N-terminal region NEMP PF10225.9 CDI84557.1 - 8 6.0 7.6 8.5 6.0 7.6 1.1 1 0 0 1 1 1 0 NEMP family PNISR PF15996.5 CDI84557.1 - 8.3 6.6 24.0 9.8 6.4 24.0 1.0 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR RskA PF10099.9 CDI84558.1 - 3e-05 24.4 50.1 0.065 13.5 10.4 4.8 2 1 0 2 2 2 2 Anti-sigma-K factor rskA DUF3371 PF11851.8 CDI84558.1 - 0.0091 17.1 17.0 0.0091 17.1 17.0 5.1 3 1 1 4 4 4 1 Domain of unknown function (DUF3371) RIFIN PF02009.16 CDI84558.1 - 0.057 13.3 0.4 0.057 13.3 0.4 4.1 2 1 1 3 3 3 0 Rifin Memo PF01875.17 CDI84559.1 - 1.1e-38 133.0 0.0 1.2e-38 132.9 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein F-box-like_2 PF13013.6 CDI84561.1 - 4 7.5 9.7 0.52 10.3 4.3 2.4 1 1 1 2 2 2 0 F-box-like domain BRCT PF00533.26 CDI84562.1 - 3.6e-05 24.1 0.0 6.5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain SR-25 PF10500.9 CDI84562.1 - 0.0044 16.7 17.8 0.0044 16.7 17.8 4.6 2 1 2 4 4 4 3 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.19 CDI84562.1 - 0.015 15.9 19.1 0.015 15.9 19.1 5.7 3 1 2 6 6 6 0 60s Acidic ribosomal protein DUF4614 PF15391.6 CDI84562.1 - 0.45 10.5 50.7 0.65 10.0 15.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4614) DUF3682 PF12446.8 CDI84563.1 - 0.0011 19.4 18.3 0.0016 18.9 18.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3682) RskA PF10099.9 CDI84563.1 - 0.003 17.9 14.6 0.0036 17.6 14.6 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Ribosomal_60s PF00428.19 CDI84563.1 - 0.0091 16.6 15.9 0.015 15.9 15.9 1.3 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF2380 PF09533.10 CDI84563.1 - 0.057 13.0 5.2 0.07 12.8 5.2 1.1 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) Baculo_PP31 PF05311.11 CDI84563.1 - 0.63 9.5 7.3 0.7 9.3 7.3 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF4207 PF13904.6 CDI84563.1 - 0.69 9.6 17.8 0.89 9.2 17.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) OmpH PF03938.14 CDI84563.1 - 0.69 10.2 22.9 0.8 10.0 22.9 1.0 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MAJIN PF15077.6 CDI84563.1 - 0.96 9.2 7.0 1.1 8.9 7.0 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein TFIIA PF03153.13 CDI84563.1 - 1 9.3 22.9 1.2 9.0 22.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit R_equi_Vir PF05526.11 CDI84563.1 - 1.3 8.9 6.4 1.5 8.6 6.4 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein BAF1_ABF1 PF04684.13 CDI84563.1 - 1.8 7.6 11.5 2 7.4 11.5 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Hydin_ADK PF17213.3 CDI84563.1 - 1.8 8.8 10.8 2.1 8.6 10.8 1.0 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain MRI PF15325.6 CDI84563.1 - 3 9.0 8.3 3.8 8.6 8.3 1.1 1 0 0 1 1 1 0 Modulator of retrovirus infection FAM60A PF15396.6 CDI84563.1 - 3.5 7.6 8.5 4 7.4 8.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Pex14_N PF04695.13 CDI84563.1 - 3.5 8.2 16.5 4.6 7.9 16.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Suf PF05843.14 CDI84563.1 - 5.6 6.9 13.6 6 6.7 13.6 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Peroxin-3 PF04882.12 CDI84563.1 - 7.2 5.5 16.0 8.3 5.3 16.0 1.0 1 0 0 1 1 1 0 Peroxin-3 Med3 PF11593.8 CDI84563.1 - 7.4 5.6 25.0 11 5.1 25.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SR-25 PF10500.9 CDI84564.1 - 0.0029 17.2 15.2 0.0029 17.2 15.2 2.0 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI84564.1 - 0.0086 16.8 5.1 0.0086 16.8 5.1 2.5 2 0 0 2 2 2 1 Immortalisation up-regulated protein SMYLE_N PF18615.1 CDI84564.1 - 1 8.9 27.4 1.5 8.3 27.4 1.4 1 1 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain DUF3446 PF11928.8 CDI84564.1 - 1.2 9.5 21.2 0.046 14.0 7.2 2.9 3 0 0 3 3 3 0 Early growth response N-terminal domain Robl_LC7 PF03259.17 CDI84564.1 - 4.9 7.0 0.0 4.9 7.0 0.0 2.9 2 1 1 3 3 3 0 Roadblock/LC7 domain DUF4770 PF15994.5 CDI84565.1 - 0.6 10.3 7.8 0.78 10.0 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Ribosomal_S8e PF01201.22 CDI84565.1 - 0.6 10.3 4.7 0.68 10.1 4.7 1.2 1 0 0 1 1 1 0 Ribosomal protein S8e MPM1 PF17234.2 CDI84565.1 - 2.2 8.5 9.3 3.1 8.0 9.3 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Mitofilin PF09731.9 CDI84565.1 - 4.2 6.1 29.4 4.8 5.9 29.4 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Plasmodium_Vir PF05795.11 CDI84565.1 - 4.4 6.6 5.4 5.1 6.4 5.4 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SLC12 PF03522.15 CDI84565.1 - 5.5 5.9 8.2 5.8 5.8 8.2 1.2 1 0 0 1 1 1 0 Solute carrier family 12 SOBP PF15279.6 CDI84565.1 - 8.1 7.0 15.0 9.4 6.7 15.0 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Pex14_N PF04695.13 CDI84566.1 - 1.3e-05 25.9 17.3 2e-05 25.3 17.3 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region SpoIIP PF07454.11 CDI84566.1 - 0.0056 16.2 13.8 0.0057 16.1 13.8 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) TFIIA PF03153.13 CDI84566.1 - 0.0061 16.6 39.2 0.0066 16.5 39.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CDI84566.1 - 0.0075 16.7 12.6 0.0094 16.3 12.6 1.3 1 0 0 1 1 1 1 Enhancer of polycomb-like DUF5308 PF17233.2 CDI84566.1 - 0.0075 16.5 9.6 0.0094 16.2 9.6 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5308) DDHD PF02862.17 CDI84566.1 - 0.0099 16.1 10.5 0.01 16.0 10.5 1.1 1 0 0 1 1 1 1 DDHD domain Gti1_Pac2 PF09729.9 CDI84566.1 - 0.028 14.5 9.9 0.031 14.4 9.9 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family ArsP_2 PF11449.8 CDI84566.1 - 0.034 13.4 2.8 0.043 13.0 2.8 1.3 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter CDC45 PF02724.14 CDI84566.1 - 0.038 12.3 12.0 0.038 12.3 12.0 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4175 PF13779.6 CDI84566.1 - 0.041 11.8 37.6 0.041 11.8 37.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CCDC53 PF10152.9 CDI84566.1 - 0.041 14.3 16.1 0.048 14.1 16.1 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex PAT1 PF09770.9 CDI84566.1 - 0.067 11.5 29.1 0.069 11.4 29.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Lin-8 PF03353.15 CDI84566.1 - 0.068 12.7 19.0 0.072 12.6 19.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 CDI84566.1 - 0.069 11.9 18.5 0.073 11.8 18.5 1.1 1 0 0 1 1 1 0 Presenilin Velvet PF11754.8 CDI84566.1 - 0.071 13.0 11.9 0.088 12.7 11.9 1.2 1 0 0 1 1 1 0 Velvet factor MMR1 PF08505.10 CDI84566.1 - 0.11 12.8 18.2 0.11 12.7 18.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein EFTUD2 PF16004.5 CDI84566.1 - 0.12 12.9 18.6 0.16 12.6 18.6 1.2 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus ALMT PF11744.8 CDI84566.1 - 0.13 11.1 13.4 0.13 11.1 13.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Membralin PF09746.9 CDI84566.1 - 0.13 11.3 9.3 0.14 11.2 9.3 1.0 1 0 0 1 1 1 0 Tumour-associated protein Tim54 PF11711.8 CDI84566.1 - 0.15 10.9 13.3 0.15 10.8 13.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SLC12 PF03522.15 CDI84566.1 - 0.17 10.9 16.0 0.18 10.8 16.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 FYDLN_acid PF09538.10 CDI84566.1 - 0.17 12.6 7.1 0.22 12.2 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) CPSF100_C PF13299.6 CDI84566.1 - 0.17 12.0 14.3 0.22 11.7 14.3 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 CDI84566.1 - 0.18 10.7 10.7 0.2 10.6 10.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4638 PF15472.6 CDI84566.1 - 0.21 11.3 11.5 0.22 11.2 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) PTPRCAP PF15713.5 CDI84566.1 - 0.23 11.7 18.4 0.28 11.5 18.4 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RR_TM4-6 PF06459.12 CDI84566.1 - 0.26 11.1 17.0 0.3 10.9 17.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pannexin_like PF12534.8 CDI84566.1 - 0.27 10.3 13.7 0.3 10.1 13.7 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 TERB2 PF15101.6 CDI84566.1 - 0.31 11.1 22.9 0.38 10.8 22.9 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Neur_chan_memb PF02932.16 CDI84566.1 - 0.31 11.1 12.0 0.34 10.9 12.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Asparaginase_2 PF01112.18 CDI84566.1 - 0.35 9.9 9.3 0.36 9.8 9.3 1.1 1 0 0 1 1 1 0 Asparaginase CNDH2_M PF16869.5 CDI84566.1 - 0.35 11.6 9.2 0.41 11.3 9.2 1.3 1 0 0 1 1 1 0 PF16858 NARP1 PF12569.8 CDI84566.1 - 0.35 9.7 16.9 0.39 9.6 16.9 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 MDM10 PF12519.8 CDI84566.1 - 0.35 9.7 12.9 0.36 9.6 12.9 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF853 PF05872.12 CDI84566.1 - 0.35 9.4 11.6 0.37 9.3 11.6 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) PPL5 PF18168.1 CDI84566.1 - 0.36 10.1 9.7 0.37 10.0 9.7 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF2828 PF11443.8 CDI84566.1 - 0.43 8.6 15.8 0.47 8.5 15.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF1764 PF08576.10 CDI84566.1 - 0.44 11.5 12.6 0.59 11.1 12.6 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Plasmodium_Vir PF05795.11 CDI84566.1 - 0.45 9.9 5.6 0.44 9.9 5.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Cellulose_synt PF03552.14 CDI84566.1 - 0.46 8.9 6.5 0.47 8.9 6.5 1.0 1 0 0 1 1 1 0 Cellulose synthase DNApol_Exo PF18136.1 CDI84566.1 - 0.46 9.6 14.5 0.53 9.4 14.5 1.1 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain PIP5K PF01504.18 CDI84566.1 - 0.54 9.4 13.3 0.61 9.3 13.3 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase CLN3 PF02487.17 CDI84566.1 - 0.54 9.2 13.1 0.64 9.0 13.1 1.1 1 0 0 1 1 1 0 CLN3 protein Peptidase_S64 PF08192.11 CDI84566.1 - 0.56 8.6 12.6 0.59 8.6 12.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 MAT1 PF06391.13 CDI84566.1 - 0.57 10.0 24.2 0.66 9.8 24.2 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 CobT PF06213.12 CDI84566.1 - 0.64 9.4 29.3 0.11 11.9 26.0 1.4 2 0 0 2 2 1 0 Cobalamin biosynthesis protein CobT Folate_carrier PF01770.18 CDI84566.1 - 0.66 8.7 7.9 0.66 8.7 7.9 1.1 1 0 0 1 1 1 0 Reduced folate carrier Ctr PF04145.15 CDI84566.1 - 0.67 10.6 10.6 0.79 10.3 10.6 1.2 1 0 0 1 1 1 0 Ctr copper transporter family BORG_CEP PF14957.6 CDI84566.1 - 0.75 11.0 9.8 0.89 10.7 9.8 1.2 1 0 0 1 1 1 0 Cdc42 effector Ureide_permease PF07168.11 CDI84566.1 - 0.78 8.4 6.9 0.9 8.2 6.9 1.1 1 0 0 1 1 1 0 Ureide permease FAM176 PF14851.6 CDI84566.1 - 0.8 9.4 11.6 0.97 9.1 11.6 1.2 1 0 0 1 1 1 0 FAM176 family Band_3_cyto PF07565.13 CDI84566.1 - 0.8 9.5 17.7 0.91 9.3 17.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Connexin PF00029.19 CDI84566.1 - 0.81 9.4 14.9 1 9.1 14.9 1.1 1 0 0 1 1 1 0 Connexin eIF3_subunit PF08597.10 CDI84566.1 - 0.93 9.4 17.6 1 9.2 17.6 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit FAM60A PF15396.6 CDI84566.1 - 0.97 9.4 12.2 1.1 9.2 12.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A GREB1 PF15782.5 CDI84566.1 - 1 6.4 15.5 1.1 6.4 15.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer YABBY PF04690.13 CDI84566.1 - 1.3 9.5 12.6 1.5 9.3 12.6 1.2 1 0 0 1 1 1 0 YABBY protein DUF3492 PF11997.8 CDI84566.1 - 1.4 8.6 8.8 1.7 8.3 8.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Slu7 PF11708.8 CDI84566.1 - 1.4 8.6 20.5 1.7 8.3 20.5 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor V_ATPase_I PF01496.19 CDI84566.1 - 1.4 6.7 18.5 1.6 6.5 18.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AIF_C PF14721.6 CDI84566.1 - 1.5 9.2 12.5 2.5 8.5 12.5 1.5 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF3408 PF11888.8 CDI84566.1 - 1.6 8.8 17.5 2.4 8.3 17.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Kei1 PF08552.11 CDI84566.1 - 1.6 8.5 10.6 1.8 8.4 10.6 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 EIIBC-GUT_N PF03612.14 CDI84566.1 - 2 8.2 14.3 2.8 7.6 14.3 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Mem_trans PF03547.18 CDI84566.1 - 2.1 6.7 4.8 1.7 6.9 4.8 1.1 1 0 0 1 1 1 0 Membrane transport protein Peptidase_S49_N PF08496.10 CDI84566.1 - 2.2 8.4 14.8 3.1 7.9 14.8 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal XRN_M PF17846.1 CDI84566.1 - 2.2 7.2 11.8 2.4 7.0 11.8 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Zip PF02535.22 CDI84566.1 - 2.2 7.4 8.4 2.1 7.5 8.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Peroxin-3 PF04882.12 CDI84566.1 - 2.3 7.1 21.5 3.1 6.7 21.5 1.1 1 0 0 1 1 1 0 Peroxin-3 SID-1_RNA_chan PF13965.6 CDI84566.1 - 2.3 6.5 8.9 2.4 6.5 8.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF966 PF06136.13 CDI84566.1 - 2.3 7.9 14.7 2.5 7.7 14.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) PepSY_TM PF03929.16 CDI84566.1 - 2.3 7.8 9.8 2.6 7.6 9.8 1.2 1 0 0 1 1 1 0 PepSY-associated TM region Scs3p PF10261.9 CDI84566.1 - 2.4 7.6 5.8 2.7 7.4 5.8 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF2126 PF09899.9 CDI84566.1 - 2.4 6.1 12.4 2.6 6.0 12.4 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) OATP PF03137.20 CDI84566.1 - 2.6 6.2 8.7 2.8 6.1 8.7 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family GPCR_chapero_1 PF11904.8 CDI84566.1 - 2.8 7.3 12.1 3.3 7.1 12.1 1.1 1 0 0 1 1 1 0 GPCR-chaperone DUF4228 PF14009.6 CDI84566.1 - 2.9 8.3 9.0 3.5 8.0 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) DUF1980 PF09323.10 CDI84566.1 - 3 7.7 13.0 3.5 7.5 13.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF4770 PF15994.5 CDI84566.1 - 3.4 7.9 18.3 4.6 7.4 18.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Hid1 PF12722.7 CDI84566.1 - 3.6 5.6 20.8 4.4 5.3 20.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Peptidase_U57 PF05582.12 CDI84566.1 - 3.7 6.7 13.5 4.4 6.5 13.5 1.1 1 0 0 1 1 1 0 YabG peptidase U57 ABC2_membrane_2 PF12679.7 CDI84566.1 - 3.8 6.7 6.3 4.6 6.4 6.3 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein TFB6 PF17110.5 CDI84566.1 - 3.9 7.2 11.0 5.3 6.8 11.0 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Bud13 PF09736.9 CDI84566.1 - 4.2 7.8 23.7 5.5 7.4 23.7 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex MDM31_MDM32 PF08118.11 CDI84566.1 - 4.5 5.8 12.7 5.5 5.6 12.7 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins HCO3_cotransp PF00955.21 CDI84566.1 - 4.7 5.9 6.6 5.2 5.8 6.6 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF4746 PF15928.5 CDI84566.1 - 5.1 6.4 14.7 5.7 6.3 14.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Ndc1_Nup PF09531.10 CDI84566.1 - 5.4 5.6 15.9 5.4 5.6 15.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ASC PF00858.24 CDI84566.1 - 5.7 5.8 9.5 6.4 5.6 9.5 1.0 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel CSG2 PF16965.5 CDI84566.1 - 6 5.7 10.6 6.9 5.5 10.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Folliculin PF11704.8 CDI84566.1 - 6 6.7 16.0 8.3 6.3 16.0 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Baculo_PP31 PF05311.11 CDI84566.1 - 6.1 6.3 15.7 7.9 5.9 15.7 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Otopetrin PF03189.13 CDI84566.1 - 6.3 5.5 11.0 6.8 5.4 11.0 1.1 1 0 0 1 1 1 0 Otopetrin Adaptin_binding PF10199.9 CDI84566.1 - 7.4 7.2 21.7 9.8 6.8 21.7 1.2 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 DUF2072 PF09845.9 CDI84566.1 - 7.9 6.8 13.3 10 6.4 13.3 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein Pet20 PF08692.10 CDI84566.1 - 8.1 7.2 8.7 11 6.8 8.7 1.3 1 0 0 1 1 1 0 Mitochondrial protein Pet20 Sec62 PF03839.16 CDI84566.1 - 8.4 5.8 17.7 11 5.4 17.7 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 STAC2_u1 PF16664.5 CDI84566.1 - 8.8 6.8 12.9 11 6.5 12.9 1.3 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Paramyxo_ncap PF00973.19 CDI84566.1 - 9.9 4.9 15.3 11 4.8 15.3 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Pilin_PilX PF11530.8 CDI84567.1 - 0.072 13.0 0.1 0.1 12.5 0.1 1.2 1 0 0 1 1 1 0 Minor type IV pilin, PilX RskA PF10099.9 CDI84567.1 - 0.2 11.9 10.9 0.24 11.7 10.9 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA THOC2_N PF16134.5 CDI84567.1 - 0.49 9.0 8.2 0.54 8.8 8.2 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus eIF-3_zeta PF05091.12 CDI84567.1 - 0.95 8.4 14.4 0.95 8.4 14.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) R_equi_Vir PF05526.11 CDI84567.1 - 1 9.2 6.8 1.2 8.9 6.8 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DDHD PF02862.17 CDI84567.1 - 1.1 9.3 9.2 1.2 9.2 9.2 1.1 1 0 0 1 1 1 0 DDHD domain TFIIA PF03153.13 CDI84567.1 - 1.4 8.9 31.5 1.5 8.7 31.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3276 PF11680.8 CDI84567.1 - 1.6 8.9 8.5 2.4 8.3 8.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) EOS1 PF12326.8 CDI84567.1 - 1.6 8.6 3.2 1.7 8.5 3.2 1.1 1 0 0 1 1 1 0 N-glycosylation protein Suf PF05843.14 CDI84567.1 - 2 8.3 12.8 1.9 8.4 12.8 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 CDI84567.1 - 2.4 8.1 6.7 2.5 8.1 6.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Usp PF00582.26 CDI84567.1 - 4.2 7.9 6.6 5.7 7.4 6.6 1.2 1 0 0 1 1 1 0 Universal stress protein family Presenilin PF01080.17 CDI84567.1 - 4.4 6.0 11.8 4.5 5.9 11.8 1.1 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 CDI84567.1 - 8.1 5.4 5.2 6.9 5.6 5.2 1.1 1 0 0 1 1 1 0 CLN3 protein DUF3881 PF12997.7 CDI84568.1 - 0.013 14.8 0.4 0.013 14.8 0.4 2.6 3 0 0 3 3 3 0 Domain of unknown function, E. rectale Gene description (DUF3881) Spt20 PF12090.8 CDI84568.1 - 0.014 15.0 10.7 0.014 15.0 10.7 3.8 2 1 1 3 3 3 0 Spt20 family Lin-8 PF03353.15 CDI84568.1 - 0.024 14.2 38.2 0.64 9.5 5.8 3.1 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist MAT1 PF06391.13 CDI84568.1 - 0.067 13.0 23.8 0.37 10.6 1.3 3.2 3 0 0 3 3 3 0 CDK-activating kinase assembly factor MAT1 MPM1 PF17234.2 CDI84568.1 - 3.1 8.0 27.0 1.1 9.6 0.7 3.4 3 0 0 3 3 3 0 Mitochondrial peculiar membrane protein 1 Spt20 PF12090.8 CDI84569.1 - 0.00058 19.6 14.0 0.00058 19.6 14.0 2.5 2 1 1 3 3 1 1 Spt20 family DUF2722 PF10846.8 CDI84569.1 - 0.007 15.4 11.0 0.007 15.4 11.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) DUF4667 PF15700.5 CDI84569.1 - 0.016 15.3 22.0 0.06 13.4 13.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) LapA_dom PF06305.11 CDI84569.1 - 0.034 14.0 1.7 0.14 12.0 1.7 2.1 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain EOS1 PF12326.8 CDI84569.1 - 0.046 13.6 4.4 2.7 7.9 1.2 2.4 2 0 0 2 2 2 0 N-glycosylation protein Presenilin PF01080.17 CDI84569.1 - 0.055 12.2 15.3 0.19 10.4 0.9 2.2 2 0 0 2 2 2 0 Presenilin Suf PF05843.14 CDI84569.1 - 0.18 11.8 17.3 0.7 9.8 5.9 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Nha1_C PF08619.10 CDI84569.1 - 0.2 10.9 14.6 0.87 8.7 6.6 2.3 2 0 0 2 2 2 0 Alkali metal cation/H+ antiporter Nha1 C terminus Lin-8 PF03353.15 CDI84569.1 - 0.21 11.1 12.3 1.3 8.5 1.0 2.4 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Apt1 PF10351.9 CDI84569.1 - 0.24 10.2 16.5 0.19 10.5 11.8 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain DUF4179 PF13786.6 CDI84569.1 - 0.39 11.2 0.1 0.39 11.2 0.1 6.2 4 1 1 5 5 3 0 Domain of unknown function (DUF4179) Otopetrin PF03189.13 CDI84569.1 - 0.64 8.8 6.8 2.5 6.8 1.0 2.1 2 0 0 2 2 2 0 Otopetrin AUX_IAA PF02309.16 CDI84569.1 - 1.1 9.1 12.2 0.83 9.5 2.3 2.5 2 0 0 2 2 2 0 AUX/IAA family Band_3_cyto PF07565.13 CDI84569.1 - 1.2 8.9 10.8 3.5 7.3 1.5 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF1387 PF07139.11 CDI84569.1 - 1.5 8.5 22.9 0.79 9.4 10.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) ERK-JNK_inhib PF15002.6 CDI84569.1 - 4.1 7.0 10.4 1.2 8.7 6.5 2.0 3 0 0 3 3 3 0 ERK and JNK pathways, inhibitor PNISR PF15996.5 CDI84569.1 - 4.8 7.4 23.1 1 9.6 6.6 2.4 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR DUF4207 PF13904.6 CDI84569.1 - 5.5 6.6 25.9 1.5 8.5 10.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) CCDC106 PF15794.5 CDI84569.1 - 8.5 6.0 21.5 3.8 7.2 12.9 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Ribosomal_60s PF00428.19 CDI84570.1 - 0.012 16.2 2.4 0.012 16.2 2.4 3.9 4 0 0 4 4 4 0 60s Acidic ribosomal protein D123 PF07065.14 CDI84570.1 - 0.014 14.5 0.0 0.014 14.5 0.0 3.5 3 1 1 4 4 4 0 D123 Cnl2_NKP2 PF09447.10 CDI84570.1 - 0.096 12.8 0.1 0.26 11.5 0.1 1.6 1 0 0 1 1 1 0 Cnl2/NKP2 family protein Tetraspanin PF00335.20 CDI84570.1 - 0.28 10.9 5.5 0.53 9.9 5.5 1.5 1 0 0 1 1 1 0 Tetraspanin family Hamartin PF04388.12 CDI84570.1 - 6.3 5.3 37.5 7.4 5.1 37.5 1.2 1 0 0 1 1 1 0 Hamartin protein Peptidase_C39 PF03412.15 CDI84571.1 - 9.9e-05 22.2 0.1 0.00025 20.9 0.1 1.7 1 0 0 1 1 1 1 Peptidase C39 family Guanylate_cyc_2 PF09778.9 CDI84571.1 - 0.0012 18.3 0.5 0.0012 18.3 0.5 1.9 1 1 1 2 2 1 1 Guanylylate cyclase Connexin PF00029.19 CDI84571.1 - 0.0021 17.9 3.1 0.0021 17.8 3.1 1.0 1 0 0 1 1 1 1 Connexin PAP_RNA-bind PF04926.15 CDI84571.1 - 0.0027 17.3 3.3 0.0031 17.2 3.3 1.0 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain SAM35 PF10806.8 CDI84571.1 - 0.0061 16.8 3.1 0.007 16.6 3.1 1.1 1 0 0 1 1 1 1 SAM35, subunit of SAM coomplex DUF2722 PF10846.8 CDI84571.1 - 0.017 14.1 26.5 0.018 14.0 26.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Tsg PF04668.12 CDI84571.1 - 0.024 15.3 5.2 0.027 15.1 5.2 1.1 1 0 0 1 1 1 0 Twisted gastrulation (Tsg) protein conserved region DUF2076 PF09849.9 CDI84571.1 - 0.027 14.5 23.2 0.028 14.5 23.2 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Mlh1_C PF16413.5 CDI84571.1 - 0.032 13.6 6.0 0.033 13.5 6.0 1.1 1 0 0 1 1 1 0 DNA mismatch repair protein Mlh1 C-terminus FAM60A PF15396.6 CDI84571.1 - 0.038 14.0 7.3 0.042 13.9 7.3 1.0 1 0 0 1 1 1 0 Protein Family FAM60A OATP PF03137.20 CDI84571.1 - 0.043 12.1 3.7 0.042 12.1 3.7 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CobT PF06213.12 CDI84571.1 - 0.061 12.7 13.5 0.058 12.8 13.5 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4770 PF15994.5 CDI84571.1 - 0.1 12.9 13.4 0.12 12.6 13.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Orf78 PF06024.12 CDI84571.1 - 0.11 12.8 4.9 0.15 12.4 4.9 1.2 1 0 0 1 1 1 0 Orf78 (ac78) DDHD PF02862.17 CDI84571.1 - 0.12 12.5 7.1 0.12 12.5 7.1 1.0 1 0 0 1 1 1 0 DDHD domain DUF4834 PF16118.5 CDI84571.1 - 0.13 13.2 11.9 0.17 12.9 11.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2126 PF09899.9 CDI84571.1 - 0.14 10.2 6.0 0.14 10.2 6.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) SpoIIP PF07454.11 CDI84571.1 - 0.16 11.4 10.1 0.17 11.3 10.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Peptidase_S49_N PF08496.10 CDI84571.1 - 0.19 11.8 6.3 0.22 11.6 6.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CCDC53 PF10152.9 CDI84571.1 - 0.22 11.9 10.3 0.26 11.7 10.3 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex TFIIA PF03153.13 CDI84571.1 - 0.22 11.5 32.0 0.25 11.3 32.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TMEM51 PF15345.6 CDI84571.1 - 0.28 11.0 12.8 0.3 10.9 12.8 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 DUF2367 PF10164.9 CDI84571.1 - 0.36 11.3 6.1 0.45 11.0 6.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) EIIBC-GUT_N PF03612.14 CDI84571.1 - 0.39 10.5 9.0 0.46 10.2 9.0 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Suf PF05843.14 CDI84571.1 - 0.39 10.7 16.8 0.43 10.5 16.8 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3408 PF11888.8 CDI84571.1 - 0.41 10.8 10.9 0.49 10.5 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Ctr PF04145.15 CDI84571.1 - 0.43 11.2 4.6 0.42 11.2 4.6 1.1 1 0 0 1 1 1 0 Ctr copper transporter family MecA PF05389.12 CDI84571.1 - 0.45 10.1 8.1 0.48 10.0 8.1 1.0 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Med15 PF09606.10 CDI84571.1 - 0.49 9.0 27.7 0.48 9.0 27.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Zip PF02535.22 CDI84571.1 - 0.49 9.6 3.8 0.46 9.6 3.8 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter AIF_C PF14721.6 CDI84571.1 - 0.5 10.7 6.8 0.55 10.6 6.8 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Pex14_N PF04695.13 CDI84571.1 - 0.53 10.9 21.3 0.6 10.8 21.3 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3464 PF11947.8 CDI84571.1 - 0.63 9.8 13.7 0.73 9.6 13.7 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Gastrin PF00918.17 CDI84571.1 - 0.69 10.9 8.2 0.72 10.8 8.2 1.1 1 0 0 1 1 1 0 Gastrin/cholecystokinin family Tim54 PF11711.8 CDI84571.1 - 0.69 8.6 9.2 0.74 8.5 9.2 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 eIF-3_zeta PF05091.12 CDI84571.1 - 0.7 8.8 15.7 0.71 8.8 15.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CPSF100_C PF13299.6 CDI84571.1 - 0.75 10.0 8.0 0.8 9.9 8.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Radical_SAM_N PF08497.10 CDI84571.1 - 0.76 9.0 4.9 0.81 8.9 4.9 1.0 1 0 0 1 1 1 0 Radical SAM N-terminal Presenilin PF01080.17 CDI84571.1 - 0.77 8.5 12.4 0.81 8.4 12.4 1.0 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI84571.1 - 0.77 9.8 7.0 0.72 9.9 7.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TERB2 PF15101.6 CDI84571.1 - 0.78 9.8 15.8 0.85 9.6 15.8 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 PIP5K PF01504.18 CDI84571.1 - 0.81 8.9 7.9 0.87 8.7 7.9 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase FAM176 PF14851.6 CDI84571.1 - 0.82 9.3 5.7 0.87 9.2 5.7 1.1 1 0 0 1 1 1 0 FAM176 family G0-G1_switch_2 PF15103.6 CDI84571.1 - 0.83 10.1 7.8 0.95 9.9 7.8 1.1 1 0 0 1 1 1 0 G0/G1 switch protein 2 RR_TM4-6 PF06459.12 CDI84571.1 - 0.86 9.4 9.5 0.89 9.3 9.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CLN3 PF02487.17 CDI84571.1 - 0.87 8.6 6.5 0.89 8.5 6.5 1.0 1 0 0 1 1 1 0 CLN3 protein DUF775 PF05603.12 CDI84571.1 - 0.89 9.0 12.0 0.92 9.0 12.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) FHIPEP PF00771.20 CDI84571.1 - 0.95 7.8 5.8 0.92 7.9 5.8 1.0 1 0 0 1 1 1 0 FHIPEP family PAT1 PF09770.9 CDI84571.1 - 1.1 7.4 20.9 1.2 7.4 20.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MAJIN PF15077.6 CDI84571.1 - 1.2 8.9 6.6 1.5 8.6 6.6 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein V_ATPase_I PF01496.19 CDI84571.1 - 1.3 6.9 10.1 1.3 6.8 10.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 CDI84571.1 - 1.3 8.3 10.5 1.3 8.3 10.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MDM10 PF12519.8 CDI84571.1 - 1.4 7.7 8.8 1.4 7.6 8.8 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 EPL1 PF10513.9 CDI84571.1 - 1.6 9.1 12.9 1.8 8.9 12.9 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like EOS1 PF12326.8 CDI84571.1 - 1.8 8.4 5.4 2 8.3 5.4 1.1 1 0 0 1 1 1 0 N-glycosylation protein Ndc1_Nup PF09531.10 CDI84571.1 - 1.9 7.0 8.8 1.8 7.1 8.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Kei1 PF08552.11 CDI84571.1 - 2 8.2 5.5 2.2 8.1 5.5 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Band_3_cyto PF07565.13 CDI84571.1 - 2.1 8.1 11.0 2.3 7.9 11.0 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Folate_carrier PF01770.18 CDI84571.1 - 2.1 7.0 6.7 2.2 6.9 6.7 1.0 1 0 0 1 1 1 0 Reduced folate carrier WASH-7_C PF14746.6 CDI84571.1 - 2.1 8.0 10.3 2.4 7.8 10.3 1.1 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal RICTOR_N PF14664.6 CDI84571.1 - 2.7 6.9 5.8 3.1 6.7 5.8 1.0 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term DUF913 PF06025.12 CDI84571.1 - 2.8 6.8 7.9 3.2 6.6 7.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4175 PF13779.6 CDI84571.1 - 3.2 5.6 28.6 3.2 5.5 28.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Serinc PF03348.15 CDI84571.1 - 4.1 6.2 6.8 4.4 6.1 6.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) ABC2_membrane_2 PF12679.7 CDI84571.1 - 4.1 6.6 4.6 4 6.6 4.6 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein Spt20 PF12090.8 CDI84571.1 - 4.3 6.9 41.6 5.5 6.5 41.6 1.1 1 0 0 1 1 1 0 Spt20 family Activator_LAG-3 PF11498.8 CDI84571.1 - 5.4 5.9 41.0 6.1 5.7 41.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 RED_N PF07808.13 CDI84571.1 - 5.5 6.5 14.6 6.2 6.3 14.6 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region ALMT PF11744.8 CDI84571.1 - 6.1 5.6 8.1 6.5 5.5 8.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter PepSY_TM PF03929.16 CDI84571.1 - 8.4 6.0 8.2 9.1 5.8 8.2 1.1 1 0 0 1 1 1 0 PepSY-associated TM region eIF_4EBP PF05456.11 CDI84571.1 - 8.8 6.3 13.4 12 5.9 13.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) DUF1980 PF09323.10 CDI84571.1 - 9 6.2 8.5 10 6.0 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF4400 PF14348.6 CDI84574.1 - 1.4e-05 24.7 6.7 1.4e-05 24.7 6.7 12.5 7 4 5 13 13 13 1 Domain of unknown function (DUF4400) NAM-associated PF14303.6 CDI84574.1 - 2e-05 25.4 0.0 2e-05 25.4 0.0 12.1 5 3 3 9 9 9 1 No apical meristem-associated C-terminal domain Activator_LAG-3 PF11498.8 CDI84574.1 - 0.00025 20.2 22.8 0.00025 20.2 22.8 10.1 8 2 1 9 9 9 2 Transcriptional activator LAG-3 SR-25 PF10500.9 CDI84574.1 - 0.0027 17.4 10.8 0.0027 17.4 10.8 12.5 7 3 4 11 11 11 3 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI84574.1 - 0.0053 17.1 0.1 0.0053 17.1 0.1 12.0 4 4 6 11 11 11 3 Anti-sigma-K factor rskA N6_N4_Mtase PF01555.18 CDI84574.1 - 0.033 13.9 8.4 0.35 10.6 0.0 5.2 4 2 0 4 4 4 0 DNA methylase Amino_oxidase PF01593.24 CDI84575.1 - 4e-18 65.9 0.0 4e-18 65.9 0.0 3.0 2 1 1 3 3 3 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDI84575.1 - 2.6e-14 53.2 0.8 2.6e-14 53.2 0.8 2.9 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CDI84575.1 - 0.0015 17.8 0.1 0.0036 16.6 0.1 1.6 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 CDI84575.1 - 0.0017 18.9 0.2 0.0044 17.5 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 CDI84575.1 - 0.013 14.9 0.0 0.013 14.9 0.0 5.1 6 1 1 7 7 7 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Presenilin PF01080.17 CDI84577.1 - 0.014 14.1 27.0 0.018 13.8 27.0 1.1 1 0 0 1 1 1 0 Presenilin Nha1_C PF08619.10 CDI84577.1 - 0.016 14.5 30.8 0.019 14.2 30.8 1.2 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus FYDLN_acid PF09538.10 CDI84577.1 - 0.029 15.1 7.5 0.029 15.1 7.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) PBP1_TM PF14812.6 CDI84577.1 - 0.55 10.6 24.7 0.62 10.5 5.8 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4598 PF15370.6 CDI84577.1 - 0.87 10.1 26.5 0.5 10.9 9.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4598) Prothymosin PF03247.14 CDI84577.1 - 1.1 9.8 37.3 0.049 14.1 17.1 2.2 2 0 0 2 2 2 0 Prothymosin/parathymosin family FAM150 PF15129.6 CDI84577.1 - 1.6 8.9 30.1 0.09 12.9 9.1 2.3 2 0 0 2 2 2 0 FAM150 family COesterase PF00135.28 CDI84577.1 - 1.6 7.5 13.2 1.8 7.3 13.2 1.1 1 0 0 1 1 1 0 Carboxylesterase family XRN_M PF17846.1 CDI84577.1 - 2.8 6.8 21.5 3.7 6.4 21.5 1.3 1 0 0 1 1 1 0 Xrn1 helical domain EFTUD2 PF16004.5 CDI84577.1 - 3.3 8.3 35.9 4 8.0 12.1 2.2 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus ORC_WH_C PF18137.1 CDI84577.1 - 4.5 7.3 28.7 1.8 8.6 10.2 2.3 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Caldesmon PF02029.15 CDI84577.1 - 4.6 5.9 37.9 5.8 5.5 37.9 1.1 1 0 0 1 1 1 0 Caldesmon Ribosomal_60s PF00428.19 CDI84577.1 - 4.9 7.8 14.0 0.11 13.1 5.7 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein SnAPC_2_like PF11035.8 CDI84577.1 - 8.2 6.5 27.7 0.18 11.9 7.8 2.1 2 0 0 2 2 2 0 Small nuclear RNA activating complex subunit 2, SNAP190 Myb GEN1_C PF18380.1 CDI84577.1 - 9.6 7.2 21.3 11 7.0 6.6 2.3 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain RskA PF10099.9 CDI84578.1 - 1.3 9.2 17.6 3.1 8.0 17.6 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI84580.1 - 0.002 17.8 1.0 0.002 17.8 1.0 2.9 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein TPPII_N PF12583.8 CDI84580.1 - 0.0081 16.8 1.3 0.0081 16.8 1.3 4.3 3 1 1 4 4 4 1 Tripeptidyl peptidase II N terminal PAN_4 PF14295.6 CDI84580.1 - 0.012 15.6 0.2 0.024 14.5 0.2 1.5 1 0 0 1 1 1 0 PAN domain PAN_2 PF08276.11 CDI84580.1 - 0.022 14.8 1.5 0.022 14.8 1.5 2.3 2 1 1 3 3 3 0 PAN-like domain PAT1 PF09770.9 CDI84580.1 - 0.29 9.3 44.3 0.019 13.3 38.9 1.6 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 AF-4 PF05110.13 CDI84580.1 - 8.9 4.3 44.1 1.8 6.6 4.9 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein SseC PF04888.12 CDI84581.1 - 4.2e-05 23.3 14.4 5.4e-05 23.0 14.4 1.1 1 0 0 1 1 1 1 Secretion system effector C (SseC) like family EPL1 PF10513.9 CDI84581.1 - 0.00035 21.0 2.7 0.00035 21.0 2.7 1.1 1 0 0 1 1 1 1 Enhancer of polycomb-like Eapp_C PF10238.9 CDI84581.1 - 0.00079 19.5 2.0 0.00079 19.5 2.0 1.1 1 0 0 1 1 1 1 E2F-associated phosphoprotein NST1 PF13945.6 CDI84581.1 - 0.0026 17.9 10.0 0.0028 17.8 10.0 1.1 1 0 0 1 1 1 1 Salt tolerance down-regulator SpoIIP PF07454.11 CDI84581.1 - 0.0033 16.9 4.7 0.0033 16.9 4.7 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) DDHD PF02862.17 CDI84581.1 - 0.0042 17.3 2.7 0.0042 17.3 2.7 1.1 1 0 0 1 1 1 1 DDHD domain Velvet PF11754.8 CDI84581.1 - 0.0076 16.2 3.2 0.0083 16.1 3.2 1.1 1 0 0 1 1 1 1 Velvet factor Presenilin PF01080.17 CDI84581.1 - 0.0086 14.9 5.2 0.0089 14.8 5.2 1.2 1 0 0 1 1 1 1 Presenilin DUF677 PF05055.12 CDI84581.1 - 0.011 14.7 1.0 0.012 14.5 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF677) DUF702 PF05142.12 CDI84581.1 - 0.013 16.0 8.6 0.015 15.8 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) RLL PF10036.9 CDI84581.1 - 0.015 15.2 8.4 0.015 15.2 8.4 1.1 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein FAM176 PF14851.6 CDI84581.1 - 0.016 14.9 1.5 0.018 14.7 1.5 1.2 1 0 0 1 1 1 0 FAM176 family TFIIA PF03153.13 CDI84581.1 - 0.02 14.9 23.1 0.021 14.8 23.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM91_C PF14648.6 CDI84581.1 - 0.022 13.6 0.5 0.021 13.7 0.5 1.1 1 0 0 1 1 1 0 FAM91 C-terminus Sarcoglycan_2 PF05510.13 CDI84581.1 - 0.023 13.5 1.7 0.025 13.4 1.7 1.1 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon GTA_holin_3TM PF11351.8 CDI84581.1 - 0.03 14.8 7.3 0.041 14.4 7.3 1.2 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release OATP PF03137.20 CDI84581.1 - 0.042 12.1 0.9 0.039 12.2 0.9 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Pex14_N PF04695.13 CDI84581.1 - 0.058 14.1 18.1 0.079 13.6 18.1 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region BRF1 PF07741.13 CDI84581.1 - 0.058 13.7 7.8 0.073 13.4 7.8 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain PAT1 PF09770.9 CDI84581.1 - 0.071 11.4 13.2 0.067 11.5 13.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ABC2_membrane_2 PF12679.7 CDI84581.1 - 0.086 12.1 3.9 0.1 11.9 3.9 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Gti1_Pac2 PF09729.9 CDI84581.1 - 0.091 12.8 4.0 0.1 12.7 4.0 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Connexin PF00029.19 CDI84581.1 - 0.093 12.5 4.6 0.11 12.2 4.6 1.2 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 CDI84581.1 - 0.1 10.5 6.5 0.098 10.6 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MDM10 PF12519.8 CDI84581.1 - 0.12 11.2 3.2 0.11 11.3 3.2 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 HCO3_cotransp PF00955.21 CDI84581.1 - 0.13 11.1 0.6 0.13 11.0 0.6 1.1 1 0 0 1 1 1 0 HCO3- transporter family Med15 PF09606.10 CDI84581.1 - 0.14 10.9 22.5 0.14 10.8 22.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SLC12 PF03522.15 CDI84581.1 - 0.14 11.2 6.0 0.13 11.2 6.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CSG2 PF16965.5 CDI84581.1 - 0.14 11.1 1.5 0.13 11.2 1.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF5308 PF17233.2 CDI84581.1 - 0.15 12.3 15.3 0.2 11.9 15.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF4770 PF15994.5 CDI84581.1 - 0.17 12.1 10.1 0.21 11.8 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Tim54 PF11711.8 CDI84581.1 - 0.18 10.5 7.0 0.19 10.5 7.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Band_3_cyto PF07565.13 CDI84581.1 - 0.19 11.5 10.5 0.22 11.3 10.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain EIIBC-GUT_N PF03612.14 CDI84581.1 - 0.2 11.4 8.4 0.25 11.1 8.4 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Orf78 PF06024.12 CDI84581.1 - 0.24 11.7 4.8 0.38 11.1 4.8 1.3 1 0 0 1 1 1 0 Orf78 (ac78) ALMT PF11744.8 CDI84581.1 - 0.24 10.2 4.2 0.24 10.2 4.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PPL5 PF18168.1 CDI84581.1 - 0.29 10.4 4.3 0.31 10.3 4.3 1.1 1 0 0 1 1 1 0 Prim-pol family 5 MCM_bind PF09739.9 CDI84581.1 - 0.31 9.4 10.7 0.39 9.1 10.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Ndc1_Nup PF09531.10 CDI84581.1 - 0.32 9.6 5.1 0.31 9.7 5.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MTP18 PF10558.9 CDI84581.1 - 0.36 10.8 5.0 0.43 10.5 5.0 1.1 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) EOS1 PF12326.8 CDI84581.1 - 0.64 9.9 4.5 0.82 9.6 4.5 1.2 1 0 0 1 1 1 0 N-glycosylation protein RIFIN PF02009.16 CDI84581.1 - 0.71 9.7 12.9 0.12 12.2 8.8 1.7 1 1 1 2 2 2 0 Rifin Spt20 PF12090.8 CDI84581.1 - 0.76 9.3 36.9 0.94 9.0 36.9 1.1 1 0 0 1 1 1 0 Spt20 family Neur_chan_memb PF02932.16 CDI84581.1 - 1 9.4 6.2 1.1 9.2 6.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TERB2 PF15101.6 CDI84581.1 - 1.2 9.1 17.7 1.5 8.8 17.7 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4647 PF15504.6 CDI84581.1 - 1.8 7.6 14.2 2 7.4 14.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DUF4199 PF13858.6 CDI84581.1 - 1.9 8.9 5.6 2.4 8.5 5.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) XRN_M PF17846.1 CDI84581.1 - 2 7.3 6.5 2.5 7.0 6.5 1.2 1 0 0 1 1 1 0 Xrn1 helical domain DUF2126 PF09899.9 CDI84581.1 - 2.4 6.1 6.8 2.3 6.2 6.8 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) RED_N PF07808.13 CDI84581.1 - 2.8 7.5 14.2 3.5 7.1 14.2 1.2 1 0 0 1 1 1 0 RED-like protein N-terminal region GREB1 PF15782.5 CDI84581.1 - 2.8 4.9 8.8 2.8 5.0 8.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer UPF0560 PF10577.9 CDI84581.1 - 3 6.2 16.9 3.3 6.1 16.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Suf PF05843.14 CDI84581.1 - 3.4 7.6 14.4 3.9 7.4 14.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MMR1 PF08505.10 CDI84581.1 - 5 7.3 17.2 5.9 7.1 17.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein eIF-3_zeta PF05091.12 CDI84581.1 - 5.6 5.8 16.8 6.4 5.6 16.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peroxin-13_N PF04088.13 CDI84581.1 - 6.8 7.0 8.6 2.7 8.2 6.4 1.5 2 0 0 2 2 1 0 Peroxin 13, N-terminal region DUF3464 PF11947.8 CDI84581.1 - 8.2 6.2 16.9 14 5.4 16.9 1.4 1 1 0 1 1 1 0 Photosynthesis affected mutant 68 SID-1_RNA_chan PF13965.6 CDI84582.1 - 0.43 8.9 2.4 0.47 8.8 2.4 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2722 PF10846.8 CDI84584.1 - 0.0012 17.9 2.1 0.0012 17.9 2.1 3.2 2 1 1 3 3 3 1 Protein of unknown function (DUF2722) SOBP PF15279.6 CDI84584.1 - 0.14 12.7 35.5 0.26 11.9 35.5 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein DUF2052 PF09747.9 CDI84584.1 - 2.9 8.0 35.0 9.8 6.3 30.6 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Rtf2 PF04641.12 CDI84584.1 - 4.9 6.4 25.3 2.3 7.5 18.6 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger Caldesmon PF02029.15 CDI84584.1 - 6.7 5.4 40.9 11 4.6 40.9 1.3 1 0 0 1 1 1 0 Caldesmon Tetraspanin PF00335.20 CDI84585.1 - 0.0063 16.3 0.0 0.072 12.8 0.7 2.3 2 1 0 2 2 2 1 Tetraspanin family DUF4692 PF15763.5 CDI84585.1 - 0.014 15.9 4.4 0.014 15.9 4.4 8.0 2 1 6 8 8 8 0 Regulator of human erythroid cell expansion (RHEX) DUF4834 PF16118.5 CDI84585.1 - 0.073 14.0 0.0 0.073 14.0 0.0 8.0 4 2 1 5 5 5 0 Domain of unknown function (DUF4834) OxoDH_E1alpha_N PF12573.8 CDI84586.1 - 0.023 14.4 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal SelB-wing_3 PF09107.11 CDI84588.1 - 0.0039 16.8 0.1 3 7.6 0.0 2.4 2 0 0 2 2 2 2 Elongation factor SelB, winged helix SR-25 PF10500.9 CDI84589.1 - 1.5e-07 31.2 56.8 0.00065 19.4 22.9 2.5 1 1 0 2 2 2 2 Nuclear RNA-splicing-associated protein DUF4614 PF15391.6 CDI84589.1 - 0.0039 17.2 43.6 0.045 13.7 16.5 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4614) eIF-3_zeta PF05091.12 CDI84589.1 - 0.36 9.8 32.4 0.092 11.7 16.9 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CDC45 PF02724.14 CDI84589.1 - 9 4.5 36.8 0.72 8.1 11.0 2.1 2 0 0 2 2 2 0 CDC45-like protein Sin_N PF04801.13 CDI84590.1 - 1.3e-05 24.6 12.5 1.3e-05 24.6 12.5 13.8 8 5 2 11 11 11 2 Sin-like protein conserved region SUIM_assoc PF16619.5 CDI84590.1 - 0.00058 19.9 1.7 0.00058 19.9 1.7 41.0 21 15 8 29 29 29 2 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI84590.1 - 0.0043 17.4 1.2 0.0043 17.4 1.2 29.8 5 5 11 20 20 20 5 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI84591.1 - 0.0095 15.6 32.7 0.02 14.5 32.1 1.8 1 1 0 1 1 1 1 Nuclear RNA-splicing-associated protein CytochromB561_N PF09786.9 CDI84591.1 - 0.54 9.2 25.6 0.61 9.0 25.6 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal SART-1 PF03343.13 CDI84591.1 - 0.81 8.2 26.4 1.2 7.6 26.4 1.3 1 0 0 1 1 1 0 SART-1 family SARAF PF06682.12 CDI84591.1 - 3.2 7.3 34.7 0.4 10.3 8.5 2.1 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis RAP1 PF07218.11 CDI84591.1 - 3.3 5.9 10.3 4 5.6 10.3 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Hamartin PF04388.12 CDI84591.1 - 8.8 4.9 39.7 11 4.5 39.7 1.2 1 0 0 1 1 1 0 Hamartin protein DUF3464 PF11947.8 CDI84592.1 - 0.00097 18.9 2.7 0.00097 18.9 2.7 7.1 2 2 3 6 6 6 1 Photosynthesis affected mutant 68 SARAF PF06682.12 CDI84594.1 - 0.0057 16.4 14.0 0.0067 16.1 14.0 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Zip PF02535.22 CDI84594.1 - 0.02 14.1 7.7 0.023 14.0 7.7 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter CBP_BcsG PF11658.8 CDI84594.1 - 0.027 12.9 14.4 0.03 12.7 14.4 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Presenilin PF01080.17 CDI84594.1 - 0.036 12.9 20.8 0.04 12.7 20.8 1.2 1 0 0 1 1 1 0 Presenilin DUF1180 PF06679.12 CDI84594.1 - 0.05 14.0 5.3 0.066 13.6 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) O-antigen_lig PF13425.6 CDI84594.1 - 0.064 12.0 9.2 0.068 11.9 9.2 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SID-1_RNA_chan PF13965.6 CDI84594.1 - 0.14 10.6 9.7 0.17 10.3 9.7 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI84594.1 - 0.15 9.9 18.2 0.18 9.7 18.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family KASH PF10541.9 CDI84594.1 - 0.39 11.0 4.9 0.57 10.5 4.9 1.2 1 0 0 1 1 1 0 Nuclear envelope localisation domain DUF4834 PF16118.5 CDI84594.1 - 1.4 9.9 34.3 1.5e+04 -3.0 34.3 2.2 1 1 0 1 1 0 0 Domain of unknown function (DUF4834) Neur_chan_memb PF02932.16 CDI84594.1 - 1.6 8.8 14.7 2.1 8.3 14.7 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Pex16 PF08610.10 CDI84594.1 - 3.3 6.8 12.0 3.7 6.6 12.0 1.0 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) Velvet PF11754.8 CDI84594.1 - 4.3 7.2 22.6 5 7.0 22.6 1.1 1 0 0 1 1 1 0 Velvet factor Membralin PF09746.9 CDI84594.1 - 4.4 6.2 13.9 4.7 6.1 13.9 1.2 1 0 0 1 1 1 0 Tumour-associated protein US2 PF02476.15 CDI84594.1 - 4.5 8.0 8.1 5.5 7.7 8.1 1.1 1 0 0 1 1 1 0 US2 family DUF2828 PF11443.8 CDI84594.1 - 7.3 4.5 20.5 8.3 4.4 20.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Lactamase_B_6 PF16661.5 CDI84595.1 - 0.00022 20.7 0.0 0.52 9.7 0.0 2.6 1 1 1 2 2 2 2 Metallo-beta-lactamase superfamily domain SPX PF03105.19 CDI84595.1 - 0.041 13.8 3.4 0.051 13.5 3.4 1.2 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI84595.1 - 0.065 12.1 3.3 0.076 11.9 3.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain TFIIA PF03153.13 CDI84595.1 - 0.066 13.2 15.1 0.095 12.7 15.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NPR3 PF03666.13 CDI84595.1 - 0.15 10.9 3.5 0.21 10.3 3.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 GREB1 PF15782.5 CDI84595.1 - 0.27 8.3 5.6 0.27 8.3 5.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 CDI84595.1 - 4.1 6.1 7.9 6.4 5.4 7.9 1.2 1 0 0 1 1 1 0 Presenilin Corona_nucleoca PF00937.18 CDI84595.1 - 8.5 5.3 16.8 16 4.4 16.8 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein RskA PF10099.9 CDI84596.1 - 1.1e-06 29.1 0.9 1.1e-06 29.1 0.9 5.1 1 1 3 4 4 3 1 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI84596.1 - 2.4e-06 26.8 28.9 4.8e-05 22.5 2.7 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI84596.1 - 0.0023 18.6 1.0 0.0023 18.6 1.0 4.0 2 1 1 3 3 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Activator_LAG-3 PF11498.8 CDI84596.1 - 0.0084 15.1 32.8 0.014 14.4 14.0 2.4 2 0 0 2 2 2 2 Transcriptional activator LAG-3 DUF2207 PF09972.9 CDI84596.1 - 0.013 14.3 1.6 0.082 11.7 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Connexin PF00029.19 CDI84596.1 - 0.1 12.4 3.0 3.4 7.4 0.0 2.4 2 0 0 2 2 2 0 Connexin DUF5523 PF17661.1 CDI84596.1 - 0.12 12.1 7.2 3.2 7.4 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) DUF4778 PF16008.5 CDI84596.1 - 0.65 10.0 15.1 0.99 9.4 7.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4778) Baculo_PP31 PF05311.11 CDI84596.1 - 1.3 8.5 16.9 0.21 11.1 3.2 2.4 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) U1snRNP70_N PF12220.8 CDI84596.1 - 2.3 8.9 19.2 0.8 10.4 4.4 3.2 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal SLC12 PF03522.15 CDI84596.1 - 6.2 5.7 15.0 2.6 7.0 1.1 2.2 2 0 0 2 2 2 0 Solute carrier family 12 EOS1 PF12326.8 CDI84596.1 - 6.6 6.6 16.1 9.8 6.1 4.2 2.5 2 0 0 2 2 2 0 N-glycosylation protein RAB3GAP2_N PF14655.6 CDI84596.1 - 7.8 5.6 15.9 5.8 6.1 2.0 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF3824 PF12868.7 CDI84597.1 - 0.28 11.8 4.2 16 6.2 3.2 2.4 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Rpp20 PF12328.8 CDI84598.1 - 0.00016 21.7 0.7 0.00045 20.2 0.7 1.8 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P DUF2722 PF10846.8 CDI84598.1 - 0.00092 18.3 5.3 0.00092 18.3 5.3 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI84598.1 - 0.0093 15.6 13.4 0.0093 15.6 13.4 2.4 2 0 0 2 2 2 1 Spt20 family Apt1 PF10351.9 CDI84598.1 - 0.021 13.7 8.2 0.022 13.6 3.7 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Plasmodium_Vir PF05795.11 CDI84598.1 - 0.037 13.5 9.6 0.1 12.0 3.0 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein EPL1 PF10513.9 CDI84598.1 - 0.042 14.2 8.0 0.73 10.2 3.2 2.5 2 0 0 2 2 2 0 Enhancer of polycomb-like Organ_specific PF10950.8 CDI84598.1 - 0.068 13.9 0.8 2.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Organ specific protein Gti1_Pac2 PF09729.9 CDI84598.1 - 0.1 12.6 7.6 1.4 9.0 0.1 2.5 2 0 0 2 2 2 0 Gti1/Pac2 family Band_3_cyto PF07565.13 CDI84598.1 - 0.18 11.6 6.5 0.41 10.4 2.1 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain SCAI PF12070.8 CDI84598.1 - 0.35 9.7 7.5 0.38 9.6 1.9 2.1 2 0 0 2 2 2 0 Protein SCAI DUF4834 PF16118.5 CDI84598.1 - 0.81 10.7 17.6 0.1 13.6 5.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF572 PF04502.13 CDI84598.1 - 2.4 7.7 14.7 8.1 6.0 13.7 2.1 1 1 0 1 1 1 0 Family of unknown function (DUF572) Kinesin_assoc PF16183.5 CDI84599.1 - 4.3 7.4 5.9 5.3 7.2 5.9 1.1 1 0 0 1 1 1 0 Kinesin-associated CAML PF14963.6 CDI84600.1 - 0.98 9.5 3.8 4.5 7.3 0.6 2.2 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand Spt20 PF12090.8 CDI84600.1 - 3.8 7.1 31.6 0.15 11.6 13.9 2.6 3 0 0 3 3 3 0 Spt20 family DUF2063 PF09836.9 CDI84600.1 - 5.8 7.2 10.3 0.33 11.2 4.5 2.0 2 0 0 2 2 2 0 Putative DNA-binding domain DDHD PF02862.17 CDI84601.1 - 0.01 16.0 4.1 0.01 16.0 4.1 3.2 2 1 1 3 3 3 0 DDHD domain Zip PF02535.22 CDI84601.1 - 0.16 11.1 13.3 0.82 8.8 1.3 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter CDC45 PF02724.14 CDI84601.1 - 2.2 6.4 34.5 0.0058 15.0 8.7 2.1 2 0 0 2 2 2 0 CDC45-like protein LCCL PF03815.19 CDI84603.1 - 2.9e-18 65.7 0.0 4.5e-18 65.2 0.0 1.2 1 0 0 1 1 1 1 LCCL domain LCCL PF03815.19 CDI84604.1 - 2.3e-15 56.4 0.0 6.5e-12 45.4 0.0 2.6 2 0 0 2 2 2 2 LCCL domain SRCR PF00530.18 CDI84604.1 - 2.3e-05 24.8 0.9 0.046 14.2 0.1 2.6 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Ribosomal_L32e PF01655.18 CDI84605.1 - 6.2e-46 155.3 0.7 7.8e-46 155.0 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 pPIWI_RE_X PF13111.6 CDI84605.1 - 0.053 12.7 0.4 0.1 11.8 0.0 1.6 2 0 0 2 2 2 0 pPIWI_RE module N-terminal domain DUF2722 PF10846.8 CDI84607.1 - 3.1e-05 23.1 2.5 3.1e-05 23.1 2.5 6.1 5 1 0 5 5 5 3 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI84607.1 - 4.9e-05 23.1 6.6 4.9e-05 23.1 6.6 6.3 5 1 0 5 5 5 4 Spt20 family Mucin PF01456.17 CDI84607.1 - 0.0011 18.9 22.5 0.0011 18.9 22.5 5.5 4 1 1 5 5 5 1 Mucin-like glycoprotein XRN_M PF17846.1 CDI84607.1 - 0.0015 17.6 3.4 0.0015 17.6 3.4 4.1 4 0 0 4 4 4 2 Xrn1 helical domain DUF4407 PF14362.6 CDI84607.1 - 0.0045 16.4 18.6 0.0045 16.4 18.6 6.3 3 2 1 4 4 4 1 Domain of unknown function (DUF4407) Connexin PF00029.19 CDI84607.1 - 0.22 11.3 38.8 0.98 9.1 0.0 5.3 5 0 0 5 5 5 0 Connexin N6_N4_Mtase PF01555.18 CDI84607.1 - 5.3 6.7 7.1 65 3.1 0.1 3.9 2 2 0 3 3 3 0 DNA methylase Asp_protease_2 PF13650.6 CDI84608.1 - 5.2e-07 30.2 0.0 1.6e-06 28.6 0.0 1.7 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI84608.1 - 6.5e-05 23.4 0.0 0.00038 20.9 0.0 2.1 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 CDI84608.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease DREPP PF05558.12 CDI84609.1 - 0.0038 17.2 1.2 0.0057 16.6 1.2 1.3 1 0 0 1 1 1 1 DREPP plasma membrane polypeptide DUF2722 PF10846.8 CDI84609.1 - 0.0072 15.3 13.2 0.0072 15.3 13.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) DUF913 PF06025.12 CDI84609.1 - 0.2 10.6 11.4 0.038 13.0 7.7 1.5 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2126 PF09899.9 CDI84609.1 - 0.21 9.6 12.7 0.28 9.2 12.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Sporozoite_P67 PF05642.11 CDI84609.1 - 0.58 8.2 3.2 0.72 7.9 3.2 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4820 PF16091.5 CDI84609.1 - 1.5 8.1 18.2 3.1 7.1 18.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4820) MPM1 PF17234.2 CDI84609.1 - 1.6 9.0 15.5 0.29 11.4 5.2 2.3 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Neur_chan_memb PF02932.16 CDI84609.1 - 2 8.4 12.5 2.7 8.0 12.5 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TMEM51 PF15345.6 CDI84609.1 - 2.2 8.1 23.5 0.72 9.6 13.4 2.1 1 1 1 2 2 2 0 Transmembrane protein 51 V_ATPase_I PF01496.19 CDI84609.1 - 2.2 6.1 18.4 2.6 5.8 18.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nha1_C PF08619.10 CDI84609.1 - 4.4 6.4 19.6 8.1 5.5 19.6 1.4 1 1 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus DUF4770 PF15994.5 CDI84609.1 - 6.3 7.0 17.7 0.14 12.4 4.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) FAM176 PF14851.6 CDI84609.1 - 6.9 6.3 10.5 0.58 9.8 4.9 2.0 2 0 0 2 2 2 0 FAM176 family DUF2721 PF11026.8 CDI84609.1 - 8.1 6.3 9.7 0.89 9.5 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) PCEMA1 PF07418.11 CDI84609.1 - 8.5 5.8 9.3 9.9 5.6 9.3 1.2 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 Bul1_C PF04426.12 CDI84610.1 - 2.3 7.5 28.3 2.8 7.3 28.3 1.0 1 0 0 1 1 1 0 Bul1 C terminus ALMT PF11744.8 CDI84610.1 - 3.3 6.4 29.6 3.9 6.2 29.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter FUN14 PF04930.15 CDI84611.1 - 0.018 15.4 1.5 4.7 7.7 0.2 2.1 2 0 0 2 2 2 0 FUN14 family ORC_WH_C PF18137.1 CDI84611.1 - 0.13 12.3 12.5 0.18 11.9 12.5 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Rtf2 PF04641.12 CDI84611.1 - 0.7 9.2 9.8 0.88 8.9 9.8 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2828 PF11443.8 CDI84611.1 - 1.3 7.0 14.0 1.4 6.9 14.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) TYW3 PF02676.14 CDI84611.1 - 1.6 8.0 7.8 2.1 7.7 7.8 1.2 1 0 0 1 1 1 0 Methyltransferase TYW3 Presenilin PF01080.17 CDI84611.1 - 2.1 7.0 18.7 2.4 6.9 18.7 1.1 1 0 0 1 1 1 0 Presenilin DUF4175 PF13779.6 CDI84611.1 - 5.7 4.7 37.7 6.5 4.5 37.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CPSF100_C PF13299.6 CDI84611.1 - 7.2 6.8 14.7 11 6.2 14.7 1.4 1 1 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CLN3 PF02487.17 CDI84611.1 - 7.4 5.5 14.2 9.6 5.1 14.2 1.2 1 0 0 1 1 1 0 CLN3 protein SLC12 PF03522.15 CDI84611.1 - 7.5 5.5 16.5 7.8 5.4 16.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 TPX2 PF06886.11 CDI84611.1 - 8.1 6.8 26.4 8.1 6.8 8.3 2.4 2 0 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) DUF4660 PF15559.6 CDI84611.1 - 9 6.7 14.2 5.5 7.4 2.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4660) GREB1 PF15782.5 CDI84612.1 - 0.13 9.4 23.1 0.12 9.5 23.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Utp14 PF04615.13 CDI84612.1 - 2.2 6.8 23.6 2.6 6.5 23.6 1.0 1 0 0 1 1 1 0 Utp14 protein ORC6 PF05460.13 CDI84612.1 - 3 7.0 26.6 3.6 6.8 26.6 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Raftlin PF15250.6 CDI84612.1 - 4.7 5.9 17.2 6.9 5.3 17.2 1.4 1 0 0 1 1 1 0 Raftlin Membralin PF09746.9 CDI84612.1 - 5.6 5.9 9.2 7.2 5.5 9.2 1.3 1 0 0 1 1 1 0 Tumour-associated protein SOG2 PF10428.9 CDI84612.1 - 7.6 5.6 46.4 9.3 5.3 46.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein CDC45 PF02724.14 CDI84613.1 - 1.6 6.9 43.2 1.8 6.8 43.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI84613.1 - 2.8 6.6 55.9 3.8 6.2 55.9 1.1 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 CDI84613.1 - 4.6 5.4 75.9 5 5.3 75.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4045 PF13254.6 CDI84613.1 - 8.1 6.0 39.4 9.7 5.7 39.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF3446 PF11928.8 CDI84615.1 - 0.17 12.2 0.3 0.17 12.2 0.3 1.9 2 0 0 2 2 2 0 Early growth response N-terminal domain Actin PF00022.19 CDI84618.1 - 0.00023 19.9 3.0 0.0011 17.6 2.0 2.3 2 1 0 2 2 2 1 Actin Androgen_recep PF02166.16 CDI84618.1 - 0.0067 15.3 6.7 0.0089 14.9 6.7 1.3 1 0 0 1 1 1 1 Androgen receptor Spt20 PF12090.8 CDI84618.1 - 0.0075 15.9 12.9 0.01 15.5 12.9 1.2 1 0 0 1 1 1 1 Spt20 family RskA PF10099.9 CDI84618.1 - 0.019 15.2 1.1 0.03 14.6 1.1 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA WRNPLPNID PF15017.6 CDI84618.1 - 0.042 14.7 5.8 0.042 14.7 5.8 1.6 2 0 0 2 2 1 0 Putative WW-binding domain and destruction box TFIIA PF03153.13 CDI84618.1 - 0.06 13.3 13.0 0.078 13.0 13.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI84618.1 - 0.072 11.8 13.9 0.087 11.5 13.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2722 PF10846.8 CDI84618.1 - 1.8 7.4 16.5 2.6 6.9 16.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Med3 PF11593.8 CDI84618.1 - 2.4 7.2 12.7 3.4 6.8 12.7 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal UPF0560 PF10577.9 CDI84618.1 - 2.4 6.5 8.3 3 6.2 8.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Roughex PF06020.11 CDI84618.1 - 3.1 6.8 8.1 4.1 6.4 8.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Activator_LAG-3 PF11498.8 CDI84618.1 - 4.1 6.3 21.1 5 6.0 21.1 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Protamine_P2 PF00841.19 CDI84618.1 - 6.2 7.4 10.4 0.53 10.8 6.0 1.5 2 0 0 2 2 1 0 Sperm histone P2 Coilin_N PF15862.5 CDI84619.1 - 0.1 12.4 5.6 0.15 11.9 5.6 1.4 1 0 0 1 1 1 0 Coilin N-terminus TFIIA PF03153.13 CDI84619.1 - 0.15 12.0 37.8 0.17 11.8 37.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4667 PF15700.5 CDI84619.1 - 0.18 11.9 9.3 0.21 11.6 9.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) Roughex PF06020.11 CDI84619.1 - 0.37 9.8 8.0 0.44 9.6 8.0 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF4834 PF16118.5 CDI84619.1 - 0.42 11.6 8.0 0.76 10.8 8.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4820 PF16091.5 CDI84619.1 - 1.7 7.9 10.5 1.5 8.1 9.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4820) Presenilin PF01080.17 CDI84619.1 - 7.7 5.2 12.9 9.1 4.9 12.9 1.3 1 0 0 1 1 1 0 Presenilin DUF2722 PF10846.8 CDI84622.1 - 2e-05 23.7 8.8 2e-05 23.7 8.8 6.6 5 1 1 7 7 7 3 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI84622.1 - 0.0013 18.4 16.9 0.0013 18.4 16.9 7.5 4 3 1 6 6 6 1 Spt20 family RskA PF10099.9 CDI84622.1 - 0.0041 17.4 6.5 0.0041 17.4 6.5 7.5 4 2 2 6 6 6 4 Anti-sigma-K factor rskA Hydrolase_4 PF12146.8 CDI84623.1 - 6e-07 29.0 0.2 6e-07 29.0 0.2 3.3 3 1 1 4 4 4 2 Serine aminopeptidase, S33 Caldesmon PF02029.15 CDI84623.1 - 0.00013 20.9 22.6 0.00013 20.9 22.6 2.7 2 1 0 2 2 2 1 Caldesmon GDA1_CD39 PF01150.17 CDI84624.1 - 0.0075 15.0 10.1 0.02 13.5 10.0 1.6 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family MarC PF01914.17 CDI84624.1 - 0.019 14.4 6.7 0.57 9.5 0.9 2.0 1 1 1 2 2 2 0 MarC family integral membrane protein AIF_C PF14721.6 CDI84624.1 - 0.031 14.6 5.2 0.038 14.4 5.2 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Ric8 PF10165.9 CDI84624.1 - 0.08 12.0 5.5 0.082 11.9 5.5 1.0 1 0 0 1 1 1 0 Guanine nucleotide exchange factor synembryn TBP PF00352.21 CDI84624.1 - 0.12 12.4 2.2 4.6 7.3 0.3 2.1 1 1 1 2 2 2 0 Transcription factor TFIID (or TATA-binding protein, TBP) Vfa1 PF08432.10 CDI84624.1 - 0.14 12.4 12.1 0.18 12.2 12.1 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 EELM2 PF15863.5 CDI84624.1 - 0.15 12.2 4.6 0.16 12.1 4.6 1.0 1 0 0 1 1 1 0 Extended EGL-27 and MTA1 homology domain IFRD_C PF04836.12 CDI84624.1 - 0.18 12.4 7.2 3 8.5 0.7 2.1 1 1 1 2 2 2 0 Interferon-related protein conserved region PRC2_HTH_1 PF18118.1 CDI84624.1 - 0.21 12.4 5.9 0.29 11.9 5.9 1.1 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain PhetRS_B1 PF18262.1 CDI84624.1 - 0.26 11.5 3.9 5.8 7.2 0.4 2.0 1 1 1 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain Spherulin4 PF12138.8 CDI84624.1 - 0.27 10.8 5.8 0.54 9.9 5.7 1.4 1 1 0 1 1 1 0 Spherulation-specific family 4 DUF1387 PF07139.11 CDI84624.1 - 0.34 10.6 11.4 0.39 10.4 11.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) INO80_Ies4 PF08193.11 CDI84624.1 - 0.34 10.9 4.6 0.4 10.6 4.6 1.1 1 0 0 1 1 1 0 INO80 complex subunit Ies4 Hydin_ADK PF17213.3 CDI84624.1 - 0.36 11.1 8.8 0.44 10.8 8.8 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Peptidase_U57 PF05582.12 CDI84624.1 - 0.42 9.8 5.9 0.42 9.8 5.9 1.0 1 0 0 1 1 1 0 YabG peptidase U57 GET2 PF08690.10 CDI84624.1 - 0.55 9.9 15.2 0.61 9.7 15.2 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 SpoIIP PF07454.11 CDI84624.1 - 0.55 9.6 9.4 0.6 9.5 9.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF1151 PF06625.11 CDI84624.1 - 0.67 9.9 19.7 0.82 9.6 19.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) DUF2126 PF09899.9 CDI84624.1 - 0.69 7.9 6.2 0.72 7.9 6.2 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) STAC2_u1 PF16664.5 CDI84624.1 - 0.87 10.0 9.1 0.99 9.9 9.1 1.1 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Pex14_N PF04695.13 CDI84624.1 - 1 10.0 15.2 1.4 9.6 15.2 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region 5_nucleotid PF05761.14 CDI84624.1 - 1.2 8.0 10.8 1.3 7.9 10.8 1.0 1 0 0 1 1 1 0 5' nucleotidase family DUF243 PF03103.17 CDI84624.1 - 1.4 9.2 17.4 8 6.9 17.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF243) GAGA_bind PF06217.12 CDI84624.1 - 2 8.6 10.9 2.2 8.5 10.9 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family Mit_KHE1 PF10173.9 CDI84624.1 - 2.2 8.3 8.5 3 7.9 8.5 1.2 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Sec62 PF03839.16 CDI84624.1 - 2.8 7.4 9.9 3.2 7.2 9.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 YABBY PF04690.13 CDI84624.1 - 3.3 8.2 9.7 3.8 8.1 9.7 1.1 1 0 0 1 1 1 0 YABBY protein TPX2 PF06886.11 CDI84624.1 - 4 7.7 22.1 5.8 7.2 6.0 2.1 2 0 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) CLN3 PF02487.17 CDI84624.1 - 4.4 6.2 9.2 4.6 6.2 9.2 1.0 1 0 0 1 1 1 0 CLN3 protein Neur_chan_memb PF02932.16 CDI84624.1 - 5 7.1 9.1 5.8 6.9 9.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EPL1 PF10513.9 CDI84624.1 - 5 7.5 11.9 7 7.0 11.9 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Presenilin PF01080.17 CDI84624.1 - 5.1 5.8 12.7 5.8 5.6 12.7 1.0 1 0 0 1 1 1 0 Presenilin Stig1 PF04885.13 CDI84624.1 - 6.9 7.1 8.4 9 6.8 8.4 1.1 1 0 0 1 1 1 0 Stigma-specific protein, Stig1 Folliculin PF11704.8 CDI84624.1 - 7.3 6.4 10.4 9.9 6.0 10.4 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Vps39_1 PF10366.9 CDI84624.1 - 8.5 6.7 14.2 8 6.8 2.6 2.1 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 1 GDA1_CD39 PF01150.17 CDI84625.1 - 5e-07 28.7 0.9 5e-07 28.7 0.9 1.5 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family BBS2_N PF14781.6 CDI84625.1 - 0.0094 15.8 0.9 0.0094 15.8 0.9 2.2 1 1 1 2 2 1 1 Ciliary BBSome complex subunit 2, N-terminal Serinc PF03348.15 CDI84625.1 - 0.011 14.7 6.0 0.013 14.5 6.0 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4484 PF14831.6 CDI84625.1 - 0.013 15.5 10.5 0.015 15.3 10.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) TetR_C_1 PF02909.17 CDI84625.1 - 0.047 13.5 0.5 0.047 13.5 0.5 2.2 2 0 0 2 2 1 0 Tetracyclin repressor-like, C-terminal domain Presenilin PF01080.17 CDI84625.1 - 0.085 11.6 22.6 0.13 11.0 22.6 1.3 1 0 0 1 1 1 0 Presenilin BAT2_N PF07001.11 CDI84625.1 - 0.2 12.1 20.4 0.29 11.6 20.4 1.3 1 0 0 1 1 1 0 BAT2 N-terminus O-antigen_lig PF13425.6 CDI84625.1 - 0.36 9.6 2.9 0.43 9.3 2.9 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein P5-ATPase PF12409.8 CDI84625.1 - 0.52 10.4 0.0 0.52 10.4 0.0 2.1 2 0 0 2 2 2 0 P5-type ATPase cation transporter Coilin_N PF15862.5 CDI84625.1 - 0.73 9.6 25.5 2.2 8.1 13.3 2.3 3 0 0 3 3 3 0 Coilin N-terminus DUF2981 PF11200.8 CDI84625.1 - 0.79 9.4 9.5 1 9.0 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) AUX_IAA PF02309.16 CDI84625.1 - 1.2 8.9 10.6 1.5 8.7 10.6 1.2 1 0 0 1 1 1 0 AUX/IAA family SARAF PF06682.12 CDI84625.1 - 2.1 7.9 16.9 4.5 6.8 16.9 1.4 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis SLC12 PF03522.15 CDI84625.1 - 3.7 6.5 20.7 4.4 6.2 20.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 BNR_3 PF13859.6 CDI84625.1 - 4.6 6.4 9.1 6.5 6.0 9.1 1.2 1 0 0 1 1 1 0 BNR repeat-like domain ORC_WH_C PF18137.1 CDI84625.1 - 4.6 7.3 22.4 3.3 7.8 0.4 2.1 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal SOBP PF15279.6 CDI84626.1 - 5.7e-05 23.9 15.2 5.7e-05 23.9 15.2 2.5 3 0 0 3 3 3 1 Sine oculis-binding protein 7tm_7 PF08395.12 CDI84626.1 - 0.0014 17.9 1.0 0.0014 17.9 1.0 3.6 4 1 0 4 4 4 1 7tm Chemosensory receptor Vut_1 PF02592.15 CDI84626.1 - 0.17 12.2 0.7 0.39 11.0 0.7 1.5 1 0 0 1 1 1 0 Putative vitamin uptake transporter NPR3 PF03666.13 CDI84626.1 - 0.87 8.3 20.6 20 3.8 0.0 2.3 2 1 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.16 CDI84626.1 - 4.6 7.2 28.8 3.6 7.6 16.7 2.9 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 CDI84626.1 - 7.3 5.5 24.4 3.9 6.4 18.1 2.4 3 0 0 3 3 3 0 Solute carrier family 12 Tic110 PF16940.5 CDI84628.1 - 0.0063 15.1 6.3 0.0083 14.7 6.3 1.3 1 0 0 1 1 1 1 Chloroplast envelope transporter MPM1 PF17234.2 CDI84628.1 - 0.018 15.3 5.0 0.018 15.3 5.0 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Lipase_GDSL_3 PF14606.6 CDI84628.1 - 0.066 13.3 0.3 0.066 13.3 0.3 1.6 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family DUF2722 PF10846.8 CDI84628.1 - 0.23 10.4 19.4 0.86 8.5 8.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI84628.1 - 0.28 10.8 28.8 0.33 10.5 10.7 2.1 2 0 0 2 2 2 0 Spt20 family Med15 PF09606.10 CDI84628.1 - 0.35 9.5 34.3 0.39 9.3 34.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Presenilin PF01080.17 CDI84628.1 - 0.5 9.1 7.9 0.69 8.6 7.9 1.2 1 0 0 1 1 1 0 Presenilin BRF1 PF07741.13 CDI84628.1 - 0.96 9.8 9.8 1.4 9.3 2.2 2.3 2 0 0 2 2 2 0 Brf1-like TBP-binding domain RPA43_OB PF17875.1 CDI84628.1 - 1.2 9.8 6.3 0.92 10.1 1.6 2.1 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I DUF4834 PF16118.5 CDI84628.1 - 1.5 9.8 10.9 2 9.4 2.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF4175 PF13779.6 CDI84628.1 - 2.3 6.0 33.8 2.7 5.8 33.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) AIF_C PF14721.6 CDI84628.1 - 3.5 8.0 6.3 1.5 9.2 0.8 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4355 PF14265.6 CDI84628.1 - 4.3 7.6 17.4 1.1 9.5 5.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) COG4 PF08318.12 CDI84628.1 - 4.5 6.2 11.4 0.27 10.3 3.2 2.0 2 0 0 2 2 2 0 COG4 transport protein Roughex PF06020.11 CDI84628.1 - 4.9 6.2 18.0 1.8 7.6 5.9 2.1 2 0 0 2 2 2 0 Drosophila roughex protein CTU2 PF10288.9 CDI84628.1 - 5.2 7.4 9.1 7.4 6.8 2.9 2.2 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Rrn6 PF10214.9 CDI84628.1 - 5.6 5.3 20.9 0.019 13.5 3.9 2.0 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor DUF775 PF05603.12 CDI84628.1 - 6.2 6.3 14.8 0.91 9.0 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF775) TERB2 PF15101.6 CDI84628.1 - 9.8 6.2 16.4 4.6 7.2 5.1 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Spore_coat_CotO PF14153.6 CDI84629.1 - 4.9 7.1 13.7 5.4 6.9 13.7 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Pox_Ag35 PF03286.14 CDI84629.1 - 5.2 6.8 22.5 6 6.6 22.5 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein LAP1C PF05609.12 CDI84629.1 - 5.8 5.9 17.8 6.1 5.8 17.8 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RNA_pol_Rpc4 PF05132.14 CDI84629.1 - 9.3 6.7 13.0 13 6.2 13.0 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 CSG2 PF16965.5 CDI84629.1 - 9.6 5.0 7.3 10 4.9 7.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF755 PF05501.11 CDI84630.1 - 0.033 14.4 0.5 0.033 14.4 0.5 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF755) Ephrin_rec_like PF07699.13 CDI84630.1 - 0.084 12.7 6.6 0.26 11.1 6.6 2.0 1 0 0 1 1 1 0 Putative ephrin-receptor like GREB1 PF15782.5 CDI84630.1 - 0.77 6.8 4.3 1.1 6.3 4.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NCD3G PF07562.14 CDI84630.1 - 2.1 8.4 7.7 5.6 7.0 1.7 2.7 1 1 1 2 2 2 0 Nine Cysteines Domain of family 3 GPCR FlgH PF02107.16 CDI84631.1 - 0.0004 20.1 0.6 0.00063 19.4 0.6 1.2 1 0 0 1 1 1 1 Flagellar L-ring protein PTPRCAP PF15713.5 CDI84631.1 - 0.00042 20.6 9.0 0.00061 20.1 9.0 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated DUF4746 PF15928.5 CDI84631.1 - 0.00092 18.7 8.9 0.00097 18.6 8.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) Pex14_N PF04695.13 CDI84631.1 - 0.0012 19.5 9.0 0.0012 19.5 9.0 2.0 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region RR_TM4-6 PF06459.12 CDI84631.1 - 0.0023 17.8 10.1 0.0024 17.7 10.1 1.2 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI84631.1 - 0.0044 16.1 7.5 0.0044 16.1 7.5 1.1 1 0 0 1 1 1 1 Solute carrier family 12 CLN3 PF02487.17 CDI84631.1 - 0.0081 15.2 6.1 0.01 14.9 6.1 1.2 1 0 0 1 1 1 1 CLN3 protein DUF913 PF06025.12 CDI84631.1 - 0.0085 15.1 3.8 0.0084 15.1 3.8 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) FAM76 PF16046.5 CDI84631.1 - 0.0087 15.5 16.2 0.013 14.9 16.2 1.2 1 0 0 1 1 1 1 FAM76 protein PIP5K PF01504.18 CDI84631.1 - 0.0089 15.3 6.8 0.0096 15.2 6.8 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PBP1_TM PF14812.6 CDI84631.1 - 0.012 16.0 5.2 0.022 15.1 5.2 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DDHD PF02862.17 CDI84631.1 - 0.013 15.7 6.0 0.015 15.5 6.0 1.2 1 0 0 1 1 1 0 DDHD domain SID-1_RNA_chan PF13965.6 CDI84631.1 - 0.015 13.8 3.1 0.016 13.7 3.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Kei1 PF08552.11 CDI84631.1 - 0.015 15.1 6.4 0.025 14.5 6.4 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Neur_chan_memb PF02932.16 CDI84631.1 - 0.018 15.1 7.3 0.021 14.9 7.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Connexin PF00029.19 CDI84631.1 - 0.018 14.8 9.6 0.031 14.0 9.6 1.3 1 0 0 1 1 1 0 Connexin EOS1 PF12326.8 CDI84631.1 - 0.02 14.8 1.7 0.022 14.7 1.7 1.3 1 0 0 1 1 1 0 N-glycosylation protein DUF2126 PF09899.9 CDI84631.1 - 0.033 12.3 9.0 0.049 11.7 9.0 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Med19 PF10278.9 CDI84631.1 - 0.035 14.0 11.3 0.05 13.5 11.3 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF4820 PF16091.5 CDI84631.1 - 0.045 13.1 6.6 0.072 12.5 6.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) PAT1 PF09770.9 CDI84631.1 - 0.06 11.6 19.3 0.066 11.5 19.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 dsRBD2 PF17842.1 CDI84631.1 - 0.073 13.3 9.6 0.022 15.0 6.5 1.6 2 0 0 2 2 1 0 Double-stranded RNA binding domain 2 Gti1_Pac2 PF09729.9 CDI84631.1 - 0.087 12.9 9.3 0.13 12.3 9.3 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Serinc PF03348.15 CDI84631.1 - 0.094 11.6 4.1 0.099 11.6 4.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Membralin PF09746.9 CDI84631.1 - 0.12 11.4 6.5 0.15 11.1 6.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF2370 PF10176.9 CDI84631.1 - 0.14 11.8 4.6 0.2 11.3 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF3464 PF11947.8 CDI84631.1 - 0.14 11.9 10.2 0.34 10.7 10.2 1.7 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF4045 PF13254.6 CDI84631.1 - 0.15 11.7 9.6 0.18 11.4 9.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SpoIIP PF07454.11 CDI84631.1 - 0.19 11.2 15.4 0.28 10.6 15.4 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) VIR_N PF15912.5 CDI84631.1 - 0.24 11.0 9.5 0.3 10.6 9.5 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Rxt3 PF08642.10 CDI84631.1 - 0.24 12.2 6.8 0.47 11.2 6.2 1.7 2 0 0 2 2 1 0 Histone deacetylation protein Rxt3 Borrelia_P83 PF05262.11 CDI84631.1 - 0.27 9.7 12.6 0.27 9.7 12.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Paf1 PF03985.13 CDI84631.1 - 0.28 10.2 18.9 0.36 9.8 18.9 1.1 1 0 0 1 1 1 0 Paf1 FAM60A PF15396.6 CDI84631.1 - 0.29 11.1 10.1 0.45 10.5 10.1 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Otopetrin PF03189.13 CDI84631.1 - 0.4 9.4 9.1 0.51 9.1 9.1 1.1 1 0 0 1 1 1 0 Otopetrin CSG2 PF16965.5 CDI84631.1 - 0.42 9.5 6.6 0.57 9.1 6.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DDRGK PF09756.9 CDI84631.1 - 0.5 9.9 28.2 0.71 9.4 28.2 1.2 1 0 0 1 1 1 0 DDRGK domain Eapp_C PF10238.9 CDI84631.1 - 0.54 10.3 25.1 1.3 9.1 25.0 1.7 1 1 0 1 1 1 0 E2F-associated phosphoprotein TRAP_alpha PF03896.16 CDI84631.1 - 0.54 9.4 7.6 0.9 8.7 7.6 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Peptidase_S49_N PF08496.10 CDI84631.1 - 0.63 10.1 11.8 1.2 9.2 11.8 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Anoctamin PF04547.12 CDI84631.1 - 0.71 8.6 4.1 1 8.1 4.1 1.3 1 0 0 1 1 1 0 Calcium-activated chloride channel NARP1 PF12569.8 CDI84631.1 - 0.95 8.3 16.4 1.3 7.9 16.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 LMBR1 PF04791.16 CDI84631.1 - 0.95 8.3 4.9 0.88 8.4 4.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein eIF-3_zeta PF05091.12 CDI84631.1 - 1.2 8.0 18.9 1.6 7.6 18.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ureide_permease PF07168.11 CDI84631.1 - 1.4 7.6 6.4 1.9 7.2 6.4 1.1 1 0 0 1 1 1 0 Ureide permease Zip PF02535.22 CDI84631.1 - 1.4 8.1 11.8 1.8 7.7 11.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 CDI84631.1 - 1.7 7.4 15.7 7.5 5.2 16.6 1.5 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Scs3p PF10261.9 CDI84631.1 - 1.7 8.1 4.8 2.5 7.5 4.8 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Afi1 PF07792.12 CDI84631.1 - 1.8 9.1 19.2 0.84 10.1 17.0 1.5 2 0 0 2 2 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PepSY_TM_like_2 PF16357.5 CDI84631.1 - 2.1 8.3 7.0 3.6 7.5 7.0 1.3 1 0 0 1 1 1 0 Putative PepSY_TM-like Cellulose_synt PF03552.14 CDI84631.1 - 2.2 6.7 4.8 2.7 6.4 4.8 1.1 1 0 0 1 1 1 0 Cellulose synthase U79_P34 PF03064.16 CDI84631.1 - 2.3 7.5 15.2 3.4 6.9 15.2 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Coilin_N PF15862.5 CDI84631.1 - 2.3 8.0 20.7 2.6 7.8 20.2 1.4 1 1 0 1 1 1 0 Coilin N-terminus HCO3_cotransp PF00955.21 CDI84631.1 - 2.5 6.8 6.2 3.4 6.4 6.2 1.1 1 0 0 1 1 1 0 HCO3- transporter family Peptidase_S64 PF08192.11 CDI84631.1 - 2.6 6.4 12.6 3.9 5.9 12.6 1.2 1 0 0 1 1 1 0 Peptidase family S64 ALMT PF11744.8 CDI84631.1 - 2.7 6.7 15.9 3.7 6.3 15.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CobT PF06213.12 CDI84631.1 - 2.7 7.3 26.3 4 6.8 26.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DcuA_DcuB PF03605.14 CDI84631.1 - 3 6.6 3.9 4.3 6.1 3.9 1.3 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Paramyxo_ncap PF00973.19 CDI84631.1 - 3.1 6.6 10.7 4.2 6.2 10.7 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein CCDC53 PF10152.9 CDI84631.1 - 3.2 8.2 18.8 0.59 10.5 14.9 1.6 2 0 0 2 2 1 0 Subunit CCDC53 of WASH complex Nucleoside_tran PF01733.18 CDI84631.1 - 3.9 6.8 7.1 6.1 6.1 7.1 1.3 1 0 0 1 1 1 0 Nucleoside transporter Folate_carrier PF01770.18 CDI84631.1 - 4 6.1 6.4 6.1 5.5 6.4 1.3 1 0 0 1 1 1 0 Reduced folate carrier Asp-B-Hydro_N PF05279.11 CDI84631.1 - 4.8 7.2 16.3 8 6.5 16.3 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region YABBY PF04690.13 CDI84631.1 - 4.9 7.7 13.2 9.2 6.8 13.2 1.4 1 0 0 1 1 1 0 YABBY protein Pal1 PF08316.11 CDI84631.1 - 4.9 7.9 8.8 8.5 7.1 8.8 1.4 1 0 0 1 1 1 0 Pal1 cell morphology protein MDM31_MDM32 PF08118.11 CDI84631.1 - 5.3 5.6 10.4 8.8 4.9 10.4 1.3 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins PIG-S PF10510.9 CDI84631.1 - 5.4 5.7 16.6 7.7 5.2 16.6 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein DUF2828 PF11443.8 CDI84631.1 - 5.6 4.9 19.0 7.6 4.5 19.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PPL5 PF18168.1 CDI84631.1 - 6.1 6.0 15.0 9.7 5.4 15.0 1.2 1 0 0 1 1 1 0 Prim-pol family 5 V_ATPase_I PF01496.19 CDI84631.1 - 6.8 4.5 22.3 8.8 4.1 22.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PepSY_TM PF03929.16 CDI84631.1 - 7.2 6.2 5.6 11 5.6 5.6 1.3 1 0 0 1 1 1 0 PepSY-associated TM region Band_3_cyto PF07565.13 CDI84631.1 - 7.9 6.2 17.8 13 5.5 17.8 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TMPIT PF07851.13 CDI84631.1 - 7.9 5.6 13.6 12 5.1 13.6 1.3 1 0 0 1 1 1 0 TMPIT-like protein EPL1 PF10513.9 CDI84631.1 - 8.7 6.7 19.5 17 5.7 19.5 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like Folliculin PF11704.8 CDI84631.1 - 9.1 6.1 11.4 17 5.3 11.4 1.4 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport OATP PF03137.20 CDI84631.1 - 9.7 4.3 7.4 13 4.0 7.4 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Ephrin_rec_like PF07699.13 CDI84632.1 - 0.0012 18.6 27.4 0.0084 15.9 7.8 4.2 1 1 3 4 4 4 4 Putative ephrin-receptor like Whib PF02467.16 CDI84632.1 - 0.068 13.8 0.9 0.068 13.8 0.9 1.6 2 0 0 2 2 2 0 Transcription factor WhiB TNFR_c6 PF00020.18 CDI84632.1 - 0.1 13.0 17.1 0.39 11.2 5.2 4.4 2 1 2 4 4 4 0 TNFR/NGFR cysteine-rich region Dickkopf_N PF04706.12 CDI84632.1 - 0.24 11.9 7.4 32 5.1 2.9 3.4 1 1 1 2 2 2 0 Dickkopf N-terminal cysteine-rich region YoaP PF14268.6 CDI84632.1 - 0.56 9.8 4.1 6 6.5 0.2 3.3 3 0 0 3 3 3 0 YoaP-like AWS PF17907.1 CDI84632.1 - 5.4 7.1 9.0 2.9 8.0 0.5 3.4 2 1 1 3 3 3 0 AWS domain Ephrin_rec_like PF07699.13 CDI84633.1 - 2.8e-07 30.2 28.3 0.00012 21.8 7.1 35.4 23 10 13 37 37 37 25 Putative ephrin-receptor like PAN_4 PF14295.6 CDI84634.1 - 1.3e-06 28.2 0.1 2.7e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.26 CDI84634.1 - 2.5e-05 24.1 0.0 6.8e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 PAN domain PAN_2 PF08276.11 CDI84634.1 - 0.0028 17.7 0.0 0.0067 16.5 0.0 1.7 1 0 0 1 1 1 1 PAN-like domain cNMP_binding PF00027.29 CDI84635.1 - 9.5e-10 38.4 0.0 1.8e-06 28.0 0.0 3.4 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Eryth_link_C PF16915.5 CDI84635.1 - 0.096 12.7 0.1 0.26 11.3 0.0 1.7 2 0 0 2 2 2 0 Annelid erythrocruorin linker subunit C-terminus BAF1_ABF1 PF04684.13 CDI84637.1 - 0.0093 15.1 18.1 0.0094 15.1 18.1 1.0 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor SelP_N PF04592.14 CDI84637.1 - 0.038 13.4 33.4 0.046 13.1 33.4 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Peptidase_S49_N PF08496.10 CDI84637.1 - 0.2 11.7 15.6 0.23 11.5 15.6 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Miga PF10265.9 CDI84637.1 - 0.24 10.3 10.7 0.24 10.3 10.7 1.0 1 0 0 1 1 1 0 Mitoguardin DUF3824 PF12868.7 CDI84637.1 - 0.48 11.1 20.3 1.3 9.7 20.4 1.6 1 1 0 1 1 1 0 Domain of unknwon function (DUF3824) HemX PF04375.14 CDI84637.1 - 0.62 9.3 36.6 0.66 9.2 36.6 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase OATP PF03137.20 CDI84637.1 - 0.77 8.0 8.9 1 7.6 8.9 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Pex14_N PF04695.13 CDI84637.1 - 0.9 10.2 33.0 1.3 9.7 33.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Serinc PF03348.15 CDI84637.1 - 0.91 8.4 12.9 1.1 8.1 12.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) CDC45 PF02724.14 CDI84637.1 - 1 7.5 18.9 1.1 7.5 18.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 CDI84637.1 - 1.1 9.0 15.9 1.1 8.9 15.9 1.1 1 0 0 1 1 1 0 Connexin RPN2_C PF18004.1 CDI84637.1 - 1.1 9.2 17.0 1.3 8.9 17.0 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain GBP_C PF02841.14 CDI84637.1 - 1.4 8.2 28.0 1.7 8.0 28.0 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain TCP PF03634.13 CDI84637.1 - 1.6 9.3 21.2 1.9 9.1 21.2 1.1 1 0 0 1 1 1 0 TCP family transcription factor SpoIIP PF07454.11 CDI84637.1 - 1.6 8.1 20.0 2.1 7.8 20.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) STAC2_u1 PF16664.5 CDI84637.1 - 1.9 9.0 17.0 2.3 8.7 17.0 1.1 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Presenilin PF01080.17 CDI84637.1 - 2.2 7.0 28.2 2.4 6.8 28.2 1.0 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 CDI84637.1 - 2.4 6.6 19.9 2.5 6.5 19.9 1.0 1 0 0 1 1 1 0 Macoilin family Gti1_Pac2 PF09729.9 CDI84637.1 - 2.4 8.2 19.0 2.5 8.2 19.0 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DDRGK PF09756.9 CDI84637.1 - 2.8 7.5 25.7 3.3 7.3 25.7 1.1 1 0 0 1 1 1 0 DDRGK domain VIR_N PF15912.5 CDI84637.1 - 2.9 7.4 13.8 3 7.4 13.8 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal FAM76 PF16046.5 CDI84637.1 - 3 7.1 23.5 3.4 7.0 23.5 1.1 1 0 0 1 1 1 0 FAM76 protein O-antigen_lig PF13425.6 CDI84637.1 - 3.2 6.4 10.8 3.7 6.2 10.8 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein FAM60A PF15396.6 CDI84637.1 - 3.5 7.6 17.2 4.1 7.4 17.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A TFIIA PF03153.13 CDI84637.1 - 3.7 7.4 50.8 4.6 7.1 50.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IHABP4_N PF16174.5 CDI84637.1 - 3.8 8.1 26.1 4.6 7.8 26.1 1.0 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal DUF4446 PF14584.6 CDI84637.1 - 4 7.4 8.2 5.2 7.0 8.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Dynamin_N PF00350.23 CDI84637.1 - 4.1 7.4 10.3 5.6 7.0 10.3 1.2 1 0 0 1 1 1 0 Dynamin family RR_TM4-6 PF06459.12 CDI84637.1 - 4.1 7.1 23.6 4.5 7.0 23.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Rtf2 PF04641.12 CDI84637.1 - 4.5 6.6 19.3 4.9 6.4 19.3 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Ureide_permease PF07168.11 CDI84637.1 - 4.8 5.8 10.1 5.7 5.6 10.1 1.2 1 0 0 1 1 1 0 Ureide permease Neur_chan_memb PF02932.16 CDI84637.1 - 5.1 7.1 19.4 5.4 7.0 19.4 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PPP4R2 PF09184.11 CDI84637.1 - 5.3 6.6 12.8 6 6.4 12.8 1.0 1 0 0 1 1 1 0 PPP4R2 Tim54 PF11711.8 CDI84637.1 - 5.3 5.7 20.2 6.1 5.5 20.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 BORG_CEP PF14957.6 CDI84637.1 - 5.4 8.2 16.4 6.4 8.0 16.4 1.1 1 0 0 1 1 1 0 Cdc42 effector SID-1_RNA_chan PF13965.6 CDI84637.1 - 5.6 5.2 11.1 6.4 5.1 11.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 CDI84637.1 - 5.9 5.8 23.4 6.2 5.7 23.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Pannexin_like PF12534.8 CDI84637.1 - 6 5.8 16.2 7.2 5.6 16.2 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 YABBY PF04690.13 CDI84637.1 - 6 7.4 18.0 7.1 7.2 18.0 1.1 1 0 0 1 1 1 0 YABBY protein PAT1 PF09770.9 CDI84637.1 - 6.1 5.0 38.4 6.4 4.9 38.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Endostatin PF06482.11 CDI84637.1 - 6.3 6.2 23.5 6.6 6.1 23.5 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin PPL5 PF18168.1 CDI84637.1 - 6.3 6.0 16.1 7.1 5.8 16.1 1.1 1 0 0 1 1 1 0 Prim-pol family 5 V_ATPase_I PF01496.19 CDI84637.1 - 6.4 4.6 25.1 6.8 4.5 25.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Band_3_cyto PF07565.13 CDI84637.1 - 6.7 6.4 21.1 8.1 6.2 21.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain eIF-3_zeta PF05091.12 CDI84637.1 - 7.4 5.4 26.3 8.5 5.2 26.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Sec62 PF03839.16 CDI84637.1 - 7.5 6.0 17.8 8 5.9 17.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2828 PF11443.8 CDI84637.1 - 8.1 4.4 22.1 9.1 4.2 22.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF3984 PF13136.6 CDI84637.1 - 9.3 5.6 22.7 12 5.2 22.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) NPR3 PF03666.13 CDI84637.1 - 9.6 4.9 20.2 11 4.7 20.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Afi1 PF07792.12 CDI84638.1 - 2.6e-09 37.6 8.8 2.4e-06 28.0 8.8 2.2 1 1 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Zip PF02535.22 CDI84638.1 - 6.2e-06 25.7 8.9 7.8e-06 25.3 8.9 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF4834 PF16118.5 CDI84638.1 - 8.5e-06 26.7 7.6 8.5e-06 26.7 7.6 2.7 1 1 2 3 3 2 1 Domain of unknown function (DUF4834) SAPS PF04499.15 CDI84638.1 - 0.00084 18.2 13.2 0.00088 18.2 13.2 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Hid1 PF12722.7 CDI84638.1 - 0.002 16.3 21.1 0.0024 16.1 21.1 1.2 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein DUF2254 PF10011.9 CDI84638.1 - 0.0062 15.4 2.1 0.0062 15.4 2.1 2.1 1 1 1 2 2 1 1 Predicted membrane protein (DUF2254) Membralin PF09746.9 CDI84638.1 - 0.031 13.3 15.4 0.043 12.8 15.4 1.3 1 0 0 1 1 1 0 Tumour-associated protein DUF3332 PF11810.8 CDI84638.1 - 0.035 13.7 7.4 0.049 13.3 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) SLC12 PF03522.15 CDI84638.1 - 0.23 10.4 30.9 0.32 10.0 30.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 PA26 PF04636.13 CDI84638.1 - 0.44 9.4 22.3 0.58 9.0 22.3 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) ALMT PF11744.8 CDI84638.1 - 0.72 8.6 26.7 0.95 8.2 26.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4045 PF13254.6 CDI84638.1 - 0.77 9.3 26.4 1 8.9 26.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Silic_transp PF03842.13 CDI84638.1 - 1.5 7.0 5.1 2.1 6.5 5.1 1.2 1 0 0 1 1 1 0 Silicon transporter RNR_inhib PF08591.10 CDI84638.1 - 2.3 9.6 21.3 4.6 8.6 21.3 1.6 1 0 0 1 1 1 0 Ribonucleotide reductase inhibitor PPP4R2 PF09184.11 CDI84638.1 - 2.3 7.7 23.4 3.3 7.2 23.4 1.2 1 0 0 1 1 1 0 PPP4R2 FAM60A PF15396.6 CDI84638.1 - 2.6 8.0 26.0 4 7.4 26.0 1.3 1 0 0 1 1 1 0 Protein Family FAM60A RskA PF10099.9 CDI84638.1 - 3 8.1 24.5 1.1e+04 -3.6 24.5 2.5 1 1 0 1 1 0 0 Anti-sigma-K factor rskA Hamartin PF04388.12 CDI84638.1 - 3.7 6.1 30.8 6 5.4 30.8 1.3 1 0 0 1 1 1 0 Hamartin protein RR_TM4-6 PF06459.12 CDI84638.1 - 4.6 7.0 37.7 7.3 6.3 37.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 WTX PF09422.10 CDI84638.1 - 4.9 6.1 21.4 6.5 5.7 21.4 1.1 1 0 0 1 1 1 0 WTX protein SID-1_RNA_chan PF13965.6 CDI84638.1 - 5.1 5.4 25.6 22 3.3 25.6 1.8 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Peptidase_S64 PF08192.11 CDI84638.1 - 5.6 5.3 24.3 8.4 4.7 24.3 1.4 1 0 0 1 1 1 0 Peptidase family S64 Hydin_ADK PF17213.3 CDI84638.1 - 7.2 6.8 26.5 11 6.2 26.5 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Glyco_hydro_9 PF00759.19 CDI84640.1 - 0.13 11.6 5.1 0.14 11.6 5.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 DUF4192 PF13830.6 CDI84640.1 - 1.1 9.2 12.1 1.8 8.6 12.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) DUF4179 PF13786.6 CDI84640.1 - 2.2 8.8 8.1 4 8.0 8.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) Androgen_recep PF02166.16 CDI84640.1 - 5.5 5.7 25.6 4.8 5.9 2.1 2.1 2 0 0 2 2 2 0 Androgen receptor GT87 PF09594.10 CDI84641.1 - 0.013 15.2 4.8 0.02 14.6 4.8 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 87 Calpain_inhib PF00748.19 CDI84641.1 - 0.019 15.5 2.5 0.019 15.5 2.5 6.0 3 1 2 5 5 5 0 Calpain inhibitor DUF3807 PF12720.7 CDI84643.1 - 2.1 8.6 18.5 2.8 8.2 18.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Presenilin PF01080.17 CDI84643.1 - 2.8 6.6 28.8 3.3 6.4 28.8 1.1 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 CDI84643.1 - 7 4.7 19.1 7.7 4.6 19.1 1.0 1 0 0 1 1 1 0 Nop14-like family Spt20 PF12090.8 CDI84644.1 - 0.0005 19.8 33.0 0.056 13.0 22.5 2.1 2 0 0 2 2 2 2 Spt20 family SRP_TPR_like PF17004.5 CDI84644.1 - 0.021 14.9 6.4 0.066 13.2 6.4 1.9 1 1 0 1 1 1 0 Putative TPR-like repeat DUF2722 PF10846.8 CDI84644.1 - 0.025 13.5 28.7 0.22 10.4 19.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) CAF1 PF04857.20 CDI84644.1 - 0.1 11.8 2.7 0.12 11.5 2.7 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease Gti1_Pac2 PF09729.9 CDI84644.1 - 0.1 12.6 4.9 0.16 12.0 4.9 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family PIP5K PF01504.18 CDI84644.1 - 0.13 11.4 3.1 0.17 11.1 3.1 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DNApol_Exo PF18136.1 CDI84644.1 - 0.37 9.9 9.2 0.53 9.4 9.2 1.2 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain GET2 PF08690.10 CDI84644.1 - 0.39 10.4 16.5 0.51 10.0 16.2 1.4 1 1 0 1 1 1 0 GET complex subunit GET2 DUF3377 PF11857.8 CDI84644.1 - 0.41 10.6 8.6 1.1 9.3 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) DUF775 PF05603.12 CDI84644.1 - 0.61 9.6 14.5 1.4 8.5 7.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF775) dsDNA_bind PF01984.20 CDI84644.1 - 0.88 9.9 32.1 0.99 9.7 17.8 2.3 2 0 0 2 2 2 0 Double-stranded DNA-binding domain Neuregulin PF02158.15 CDI84644.1 - 0.9 8.8 10.0 1.5 8.1 10.0 1.3 1 0 0 1 1 1 0 Neuregulin intracellular region Gag_p17 PF00540.18 CDI84644.1 - 1 9.3 8.0 0.88 9.6 2.6 2.5 2 0 0 2 2 2 0 gag gene protein p17 (matrix protein) Spore_YhcN_YlaJ PF09580.10 CDI84644.1 - 1.4 9.0 11.8 0.58 10.2 4.5 2.1 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Fig1 PF12351.8 CDI84644.1 - 3.1 7.7 13.0 5.7 6.8 13.0 1.5 1 1 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 SID-1_RNA_chan PF13965.6 CDI84644.1 - 3.6 5.9 9.5 2.1 6.6 8.1 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 AUX_IAA PF02309.16 CDI84644.1 - 4.2 7.2 8.2 6 6.7 8.2 1.3 1 0 0 1 1 1 0 AUX/IAA family MDM10 PF12519.8 CDI84644.1 - 5.3 5.8 8.7 7.6 5.3 8.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Neur_chan_memb PF02932.16 CDI84644.1 - 5.8 6.9 10.9 2.5 8.1 8.9 1.5 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PAT1 PF09770.9 CDI84644.1 - 6.7 4.9 24.3 8.4 4.5 24.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AUX_IAA PF02309.16 CDI84645.1 - 1.6 8.5 3.3 0.66 9.8 0.8 1.6 2 0 0 2 2 2 0 AUX/IAA family Cyt_bd_oxida_II PF02322.15 CDI84645.1 - 6.2 6.1 25.9 0.036 13.4 16.6 1.9 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II AAA_23 PF13476.6 CDI84646.1 - 2.6 8.5 42.2 2.6 8.5 18.5 2.1 2 0 0 2 2 2 0 AAA domain DcuA_DcuB PF03605.14 CDI84646.1 - 2.6 6.8 32.2 0.46 9.3 18.8 2.3 2 1 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter rRNA_processing PF08524.11 CDI84646.1 - 8 6.5 59.1 0.83 9.7 23.6 2.7 3 0 0 3 3 3 0 rRNA processing Asp-B-Hydro_N PF05279.11 CDI84647.1 - 0.64 10.1 48.1 1.1 9.3 48.1 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region E7 PF00527.18 CDI84649.1 - 0.017 15.3 3.1 0.017 15.3 3.1 4.3 3 1 0 3 3 3 0 E7 protein, Early protein RskA PF10099.9 CDI84650.1 - 0.023 15.0 15.8 0.031 14.6 15.8 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI84650.1 - 0.041 13.9 5.5 0.044 13.8 5.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI84650.1 - 0.19 11.3 10.2 0.22 11.1 10.2 1.1 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 CDI84650.1 - 0.26 10.4 4.5 0.32 10.0 4.5 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Activator_LAG-3 PF11498.8 CDI84650.1 - 0.83 8.6 14.2 1.1 8.2 14.2 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF2722 PF10846.8 CDI84650.1 - 1.1 8.1 8.7 1.3 7.9 8.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Dehydrin PF00257.19 CDI84650.1 - 2.6 8.6 11.7 3.6 8.1 11.7 1.2 1 0 0 1 1 1 0 Dehydrin SDA1 PF05285.12 CDI84651.1 - 4.6 6.6 17.1 6.5 6.1 17.1 1.3 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 CDI84651.1 - 6 6.1 19.9 8.3 5.6 19.9 1.3 1 0 0 1 1 1 0 BUD22 DUF2457 PF10446.9 CDI84651.1 - 7.8 5.5 28.8 9 5.3 28.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) AAA_23 PF13476.6 CDI84652.1 - 0.0022 18.5 0.4 0.0022 18.5 0.4 3.1 3 0 0 3 3 3 1 AAA domain Mit_KHE1 PF10173.9 CDI84652.1 - 0.65 10.1 7.2 8.9 6.3 1.1 3.2 3 0 0 3 3 3 0 Mitochondrial K+-H+ exchange-related Apt1 PF10351.9 CDI84652.1 - 1.2 7.9 0.0 1.2 7.9 0.0 4.5 3 2 0 4 4 4 0 Golgi-body localisation protein domain Activator_LAG-3 PF11498.8 CDI84653.1 - 1 8.2 55.2 1.3 7.9 55.2 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Hydin_ADK PF17213.3 CDI84653.1 - 4.6 7.5 9.2 5.3 7.3 9.2 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Androgen_recep PF02166.16 CDI84654.1 - 0.0045 15.9 6.3 0.0045 15.9 6.3 8.1 5 3 3 8 8 8 1 Androgen receptor VPS13_C PF16909.5 CDI84654.1 - 0.017 14.9 1.8 0.034 13.9 0.1 2.5 2 1 0 2 2 2 0 Vacuolar-sorting-associated 13 protein C-terminal SR-25 PF10500.9 CDI84654.1 - 2.8 7.5 47.5 0.12 12.0 24.0 4.3 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI84655.1 - 0.025 15.3 10.5 0.025 15.3 10.5 1.8 2 0 0 2 2 2 0 Immortalisation up-regulated protein DUF3138 PF11336.8 CDI84655.1 - 0.11 11.1 0.9 0.12 11.0 0.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) HSD3 PF15244.6 CDI84655.1 - 0.14 11.6 8.5 0.16 11.5 8.5 1.0 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 DUF1635 PF07795.11 CDI84655.1 - 0.25 11.2 8.5 0.27 11.1 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Band_3_cyto PF07565.13 CDI84655.1 - 0.26 11.0 3.9 0.3 10.8 3.9 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RAP1 PF07218.11 CDI84655.1 - 0.89 7.8 8.7 0.95 7.7 8.7 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) F-protein PF00469.20 CDI84655.1 - 1.4 8.5 7.7 1.4 8.4 7.7 1.2 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef SR-25 PF10500.9 CDI84655.1 - 1.6 8.3 22.4 2.4 7.7 22.4 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 CDI84655.1 - 2 8.7 19.3 0.12 12.6 14.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF755) PBP1_TM PF14812.6 CDI84655.1 - 2.1 8.8 19.2 1.3 9.4 2.5 2.1 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CAML PF14963.6 CDI84655.1 - 2.2 8.3 7.2 2.4 8.2 7.2 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand SBF2 PF12335.8 CDI84655.1 - 2.2 7.8 8.9 2.5 7.7 8.9 1.2 1 0 0 1 1 1 0 Myotubularin protein Lin-8 PF03353.15 CDI84655.1 - 6.5 6.2 14.9 7.4 6.0 14.9 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DHHW PF14286.6 CDI84655.1 - 6.9 5.9 8.0 8.4 5.6 8.0 1.1 1 0 0 1 1 1 0 DHHW protein KBP_C PF12309.8 CDI84656.1 - 1.9e-15 57.3 0.0 1.9e-15 57.3 0.0 7.1 4 3 3 7 7 7 1 KIF-1 binding protein C terminal Spt20 PF12090.8 CDI84656.1 - 6.3e-06 26.0 41.0 2.6e-05 24.0 11.8 8.6 5 1 2 7 7 7 3 Spt20 family TFIIA PF03153.13 CDI84656.1 - 1.8e-05 24.9 18.8 1.8e-05 24.9 18.8 6.6 2 1 2 5 5 5 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI84656.1 - 4.3e-05 22.7 11.5 4.3e-05 22.7 11.5 8.5 5 2 2 7 7 7 2 Protein of unknown function (DUF2722) SR-25 PF10500.9 CDI84656.1 - 0.0011 18.6 8.1 0.0011 18.6 8.1 8.6 6 2 0 7 7 7 2 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI84656.1 - 0.0013 19.1 141.0 0.052 13.8 23.0 8.7 3 2 1 6 6 6 1 Anti-sigma-K factor rskA Suf PF05843.14 CDI84656.1 - 0.0084 16.1 12.0 0.0084 16.1 12.0 7.2 3 1 2 5 5 5 1 Suppressor of forked protein (Suf) DUF2722 PF10846.8 CDI84657.1 - 0.0014 17.7 5.9 0.0014 17.7 5.9 4.1 2 1 2 4 4 4 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI84657.1 - 0.0024 17.5 12.9 0.0024 17.5 12.9 4.2 2 1 2 4 4 4 1 Spt20 family Phostensin_N PF13916.6 CDI84657.1 - 0.0087 16.4 0.9 0.0087 16.4 0.9 5.3 4 1 0 4 4 4 2 PP1-regulatory protein, Phostensin N-terminal M_domain PF12938.7 CDI84658.1 - 0.0015 18.4 14.8 0.0015 18.4 14.8 4.9 2 1 2 4 4 4 1 M domain of GW182 DUF4207 PF13904.6 CDI84658.1 - 0.6 9.7 58.2 0.15 11.7 39.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) FAM76 PF16046.5 CDI84658.1 - 8.1 5.7 37.7 4.8 6.4 22.7 2.1 2 0 0 2 2 2 0 FAM76 protein DUF4746 PF15928.5 CDI84659.1 - 0.11 12.0 12.3 0.19 11.1 12.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4401 PF14351.6 CDI84659.1 - 0.24 10.6 8.5 0.32 10.3 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4401) CDC45 PF02724.14 CDI84659.1 - 0.85 7.8 19.3 1 7.6 19.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S64 PF08192.11 CDI84659.1 - 0.97 7.8 23.4 1.2 7.6 23.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 SRP-alpha_N PF04086.13 CDI84659.1 - 2.3 8.0 27.7 3 7.7 27.7 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SOBP PF15279.6 CDI84659.1 - 5.2 7.6 39.4 6.3 7.3 39.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein PAT1 PF09770.9 CDI84659.1 - 6.1 5.0 57.5 7.9 4.6 57.5 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4834 PF16118.5 CDI84660.1 - 2.2e-05 25.3 8.6 3.3e-05 24.8 8.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) FAM176 PF14851.6 CDI84660.1 - 0.00053 19.7 1.1 0.0006 19.5 1.1 1.1 1 0 0 1 1 1 1 FAM176 family CLN3 PF02487.17 CDI84660.1 - 0.0013 17.9 7.5 0.0014 17.8 7.5 1.0 1 0 0 1 1 1 1 CLN3 protein FHIPEP PF00771.20 CDI84660.1 - 0.0022 16.6 6.0 0.0026 16.3 6.0 1.1 1 0 0 1 1 1 1 FHIPEP family CPSF100_C PF13299.6 CDI84660.1 - 0.0023 18.2 6.4 0.0023 18.1 6.4 1.1 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal CobT PF06213.12 CDI84660.1 - 0.0036 16.7 16.7 0.0036 16.7 16.7 1.1 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT eIF-3_zeta PF05091.12 CDI84660.1 - 0.0046 16.0 15.9 0.0046 16.0 15.9 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SID-1_RNA_chan PF13965.6 CDI84660.1 - 0.0079 14.7 4.2 0.0083 14.6 4.2 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 G0-G1_switch_2 PF15103.6 CDI84660.1 - 0.0085 16.5 6.1 0.0093 16.4 6.1 1.2 1 0 0 1 1 1 1 G0/G1 switch protein 2 MecA PF05389.12 CDI84660.1 - 0.012 15.3 7.3 0.012 15.2 7.3 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DDHD PF02862.17 CDI84660.1 - 0.014 15.6 9.9 0.013 15.6 9.9 1.0 1 0 0 1 1 1 0 DDHD domain DUF4175 PF13779.6 CDI84660.1 - 0.015 13.3 31.5 0.014 13.3 31.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Baculo_PP31 PF05311.11 CDI84660.1 - 0.016 14.7 9.4 0.014 14.9 9.4 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Serinc PF03348.15 CDI84660.1 - 0.034 13.1 5.8 0.034 13.1 5.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4820 PF16091.5 CDI84660.1 - 0.037 13.4 8.5 0.04 13.3 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF1980 PF09323.10 CDI84660.1 - 0.039 13.9 8.3 0.04 13.8 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) V_ATPase_I PF01496.19 CDI84660.1 - 0.039 11.9 11.9 0.036 12.0 11.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF913 PF06025.12 CDI84660.1 - 0.041 12.9 5.0 0.038 13.0 5.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Peroxin-13_N PF04088.13 CDI84660.1 - 0.041 14.2 4.6 0.04 14.2 4.6 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region EIIBC-GUT_N PF03612.14 CDI84660.1 - 0.043 13.5 9.6 0.042 13.6 9.6 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Folate_carrier PF01770.18 CDI84660.1 - 0.044 12.5 6.1 0.051 12.3 6.1 1.2 1 0 0 1 1 1 0 Reduced folate carrier CBP_BcsG PF11658.8 CDI84660.1 - 0.054 11.9 8.7 0.054 11.9 8.7 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DcuA_DcuB PF03605.14 CDI84660.1 - 0.058 12.3 3.5 0.074 11.9 3.5 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter SpoIIP PF07454.11 CDI84660.1 - 0.06 12.8 15.3 0.061 12.8 15.3 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PIP5K PF01504.18 CDI84660.1 - 0.074 12.3 9.4 0.069 12.4 9.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase AP-5_subunit_s1 PF15001.6 CDI84660.1 - 0.075 13.0 12.7 0.081 12.9 12.7 1.1 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 OATP PF03137.20 CDI84660.1 - 0.09 11.1 6.2 0.083 11.2 6.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3408 PF11888.8 CDI84660.1 - 0.093 12.9 13.6 0.1 12.7 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) ALMT PF11744.8 CDI84660.1 - 0.11 11.3 6.5 0.1 11.4 6.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 CDI84660.1 - 0.13 12.4 7.2 0.11 12.5 7.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MTP18 PF10558.9 CDI84660.1 - 0.14 12.1 4.0 0.15 12.0 4.0 1.3 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) DUF4228 PF14009.6 CDI84660.1 - 0.14 12.5 5.5 0.15 12.4 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) CCDC53 PF10152.9 CDI84660.1 - 0.15 12.5 13.3 0.14 12.6 13.3 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex TFIIA PF03153.13 CDI84660.1 - 0.16 12.0 38.9 0.15 12.0 38.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zip PF02535.22 CDI84660.1 - 0.19 10.9 1.9 0.18 11.0 1.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3292 PF11696.8 CDI84660.1 - 0.24 9.7 7.7 0.23 9.8 7.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) RICTOR_N PF14664.6 CDI84660.1 - 0.25 10.3 3.8 0.26 10.2 3.8 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term DUF2072 PF09845.9 CDI84660.1 - 0.26 11.5 12.8 0.32 11.2 12.8 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein YABBY PF04690.13 CDI84660.1 - 0.27 11.8 8.8 0.25 11.9 8.8 1.1 1 0 0 1 1 1 0 YABBY protein Tmp39 PF10271.9 CDI84660.1 - 0.29 10.1 2.4 0.29 10.1 2.4 1.0 1 0 0 1 1 1 0 Putative transmembrane protein AGTRAP PF06396.11 CDI84660.1 - 0.32 10.8 2.7 0.4 10.5 2.7 1.1 1 0 0 1 1 1 0 Angiotensin II, type I receptor-associated protein (AGTRAP) NEMP PF10225.9 CDI84660.1 - 0.33 10.6 6.1 0.37 10.4 6.1 1.1 1 0 0 1 1 1 0 NEMP family Rxt3 PF08642.10 CDI84660.1 - 0.33 11.7 6.9 0.38 11.5 6.9 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Vps39_2 PF10367.9 CDI84660.1 - 0.34 11.4 9.4 0.44 11.0 9.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 DcuC PF03606.15 CDI84660.1 - 0.35 9.3 2.6 0.38 9.2 2.6 1.1 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier DUF2828 PF11443.8 CDI84660.1 - 0.38 8.8 13.4 0.37 8.8 13.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) RskA PF10099.9 CDI84660.1 - 0.4 11.0 14.7 1.3 9.3 14.7 1.7 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Cellulose_synt PF03552.14 CDI84660.1 - 0.43 9.0 2.7 0.39 9.1 2.7 1.0 1 0 0 1 1 1 0 Cellulose synthase Nucleoside_tran PF01733.18 CDI84660.1 - 0.45 9.9 3.9 0.52 9.6 3.9 1.1 1 0 0 1 1 1 0 Nucleoside transporter PAT1 PF09770.9 CDI84660.1 - 0.52 8.5 26.0 0.5 8.6 26.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 HemX PF04375.14 CDI84660.1 - 0.67 9.2 30.6 0.71 9.1 30.6 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase HCO3_cotransp PF00955.21 CDI84660.1 - 0.68 8.7 4.7 0.69 8.7 4.7 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF1682 PF07946.14 CDI84660.1 - 0.77 8.9 13.6 0.77 8.9 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) EPL1 PF10513.9 CDI84660.1 - 0.79 10.1 16.0 0.87 10.0 16.0 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like O-antigen_lig PF13425.6 CDI84660.1 - 1.1 8.0 4.2 0.98 8.1 4.2 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Tim54 PF11711.8 CDI84660.1 - 1.1 7.9 14.5 1.2 7.8 14.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Herpes_glycop PF01528.16 CDI84660.1 - 1.2 7.9 3.4 1.6 7.5 3.4 1.2 1 0 0 1 1 1 0 Herpesvirus glycoprotein M DUF2126 PF09899.9 CDI84660.1 - 1.4 6.9 10.3 1.3 7.0 10.3 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) MDM31_MDM32 PF08118.11 CDI84660.1 - 1.6 7.3 10.2 1.6 7.3 10.2 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Band_3_cyto PF07565.13 CDI84660.1 - 1.7 8.3 15.7 1.9 8.2 15.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain AAA_23 PF13476.6 CDI84660.1 - 2.3 8.7 20.1 2.6 8.5 20.1 1.1 1 0 0 1 1 1 0 AAA domain Yos1 PF08571.10 CDI84660.1 - 2.4 8.5 4.4 5.6 7.3 4.2 1.8 1 1 0 1 1 1 0 Yos1-like Asparaginase_2 PF01112.18 CDI84660.1 - 2.5 7.0 8.0 2.7 6.9 8.0 1.2 1 0 0 1 1 1 0 Asparaginase Membralin PF09746.9 CDI84660.1 - 2.9 6.8 9.0 3.1 6.7 9.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein FAM60A PF15396.6 CDI84660.1 - 4.2 7.3 12.5 4.5 7.2 12.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A RR_TM4-6 PF06459.12 CDI84660.1 - 4.6 7.0 17.9 5.1 6.8 17.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI84660.1 - 4.9 6.1 19.4 5.8 5.8 19.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Ndc1_Nup PF09531.10 CDI84660.1 - 9.2 4.8 14.5 8.6 4.9 14.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SR-25 PF10500.9 CDI84661.1 - 3e-05 23.8 15.5 3e-05 23.8 15.5 2.4 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI84661.1 - 0.071 13.4 53.8 0.074 13.3 20.8 3.7 1 1 1 3 3 3 0 Anti-sigma-K factor rskA DUF5134 PF17197.4 CDI84661.1 - 0.17 11.8 15.0 0.13 12.2 2.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5134) DUF4179 PF13786.6 CDI84661.1 - 1.9 9.0 0.0 1.9 9.0 0.0 3.8 2 2 2 4 4 4 0 Domain of unknown function (DUF4179) AF-4 PF05110.13 CDI84662.1 - 0.00037 18.7 28.0 0.00046 18.4 28.0 1.1 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Macoilin PF09726.9 CDI84662.1 - 0.0046 15.6 18.8 0.0056 15.3 18.8 1.0 1 0 0 1 1 1 1 Macoilin family Lin-8 PF03353.15 CDI84662.1 - 0.014 15.0 24.4 0.018 14.6 24.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2457 PF10446.9 CDI84662.1 - 0.015 14.4 10.0 0.018 14.2 10.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Exonuc_VII_L PF02601.15 CDI84662.1 - 0.074 12.6 21.2 0.1 12.2 21.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CytochromB561_N PF09786.9 CDI84662.1 - 0.078 12.0 14.3 0.098 11.6 14.3 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal TFIIA PF03153.13 CDI84662.1 - 0.21 11.5 37.9 0.25 11.3 37.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI84662.1 - 0.43 8.8 28.4 0.51 8.5 28.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Cwf_Cwc_15 PF04889.12 CDI84662.1 - 0.47 10.1 17.0 0.61 9.8 17.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PolC_DP2 PF03833.13 CDI84662.1 - 0.5 8.2 5.8 0.58 7.9 5.8 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 PA26 PF04636.13 CDI84662.1 - 0.54 9.1 10.9 0.65 8.9 10.9 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF572 PF04502.13 CDI84662.1 - 0.73 9.4 14.2 0.89 9.1 14.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) ChaC PF04752.12 CDI84662.1 - 0.77 9.8 6.6 1.1 9.3 6.6 1.2 1 0 0 1 1 1 0 ChaC-like protein Med15 PF09606.10 CDI84662.1 - 0.77 8.4 29.4 0.93 8.1 29.4 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAP1 PF08601.10 CDI84662.1 - 0.78 9.4 23.4 1 9.0 23.4 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 MAT1 PF06391.13 CDI84662.1 - 0.89 9.3 21.0 1.1 9.0 21.0 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF3381 PF11861.8 CDI84662.1 - 1.3 8.8 15.5 1.8 8.3 15.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF2052 PF09747.9 CDI84662.1 - 1.5 8.9 15.0 1.8 8.7 15.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) FapA PF03961.13 CDI84662.1 - 1.9 7.0 8.9 2.2 6.8 8.9 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Miga PF10265.9 CDI84662.1 - 2.3 7.1 16.9 2.9 6.8 16.9 1.1 1 0 0 1 1 1 0 Mitoguardin SID-1_RNA_chan PF13965.6 CDI84662.1 - 2.6 6.3 6.4 3.1 6.1 6.4 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NST1 PF13945.6 CDI84662.1 - 2.7 8.1 23.4 4 7.5 23.4 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator FliP PF00813.20 CDI84662.1 - 3.6 7.4 5.7 4.3 7.2 5.7 1.3 1 0 0 1 1 1 0 FliP family GREB1 PF15782.5 CDI84662.1 - 5.4 4.0 25.8 6.2 3.8 25.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Plasmodium_Vir PF05795.11 CDI84662.1 - 6.4 6.1 11.1 7.5 5.9 11.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Golgin_A5 PF09787.9 CDI84662.1 - 6.4 6.2 29.7 8.5 5.7 29.7 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 V_ATPase_I PF01496.19 CDI84662.1 - 6.7 4.5 15.7 8.1 4.2 15.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 CDI84662.1 - 6.8 6.4 16.4 7.8 6.2 16.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pkinase PF00069.25 CDI84663.1 - 5.6e-05 22.6 0.0 8.3e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CDI84663.1 - 0.0019 17.5 0.0 0.0036 16.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RskA PF10099.9 CDI84664.1 - 9.9e-07 29.2 0.9 9.9e-07 29.2 0.9 5.4 2 2 0 3 3 1 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI84664.1 - 0.00011 21.9 22.1 0.00011 21.9 22.1 3.9 4 0 0 4 4 4 2 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI84664.1 - 0.0028 16.7 16.0 0.0028 16.7 16.0 3.3 3 1 0 3 3 2 1 Protein of unknown function (DUF2722) Activator_LAG-3 PF11498.8 CDI84664.1 - 0.004 16.2 17.6 0.004 16.2 17.6 2.7 2 1 0 2 2 1 1 Transcriptional activator LAG-3 Zip PF02535.22 CDI84664.1 - 0.015 14.5 19.2 0.76 8.9 12.8 2.7 2 0 0 2 2 2 0 ZIP Zinc transporter NTP_transf_2 PF01909.23 CDI84664.1 - 0.02 15.1 0.0 0.049 13.9 0.0 1.6 1 0 0 1 1 1 0 Nucleotidyltransferase domain SpoIIP PF07454.11 CDI84664.1 - 0.058 12.9 21.4 0.47 9.9 9.0 2.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 CDI84664.1 - 0.28 10.9 15.6 0.97 9.1 1.8 2.4 2 0 0 2 2 2 0 Connexin SID-1_RNA_chan PF13965.6 CDI84664.1 - 0.66 8.3 9.9 1.7 7.0 2.6 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 GPCR_chapero_1 PF11904.8 CDI84664.1 - 0.78 9.1 13.0 2.1 7.7 2.9 2.4 2 0 0 2 2 2 0 GPCR-chaperone SLC12 PF03522.15 CDI84664.1 - 1.1 8.2 26.0 1.6 7.7 7.1 2.3 2 0 0 2 2 2 0 Solute carrier family 12 Suf PF05843.14 CDI84664.1 - 1.1 9.1 37.0 0.35 10.8 13.7 2.6 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) Peptidase_S49_N PF08496.10 CDI84664.1 - 1.2 9.2 18.1 2.2 8.3 8.3 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Nop53 PF07767.11 CDI84664.1 - 1.2 8.5 33.3 0.31 10.4 6.8 2.7 3 0 0 3 3 3 0 Nop53 (60S ribosomal biogenesis) MecA PF05389.12 CDI84664.1 - 1.2 8.7 16.3 1.3 8.6 5.3 2.5 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) Vfa1 PF08432.10 CDI84664.1 - 1.3 9.4 32.2 1.2 9.4 8.8 2.8 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 MAT1 PF06391.13 CDI84664.1 - 1.5 8.6 23.8 3.4 7.4 4.6 2.7 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 GEMIN8 PF15348.6 CDI84664.1 - 2.1 8.6 41.7 0.66 10.2 13.4 3.2 3 0 0 3 3 3 0 Gemini of Cajal bodies-associated protein 8 PAT1 PF09770.9 CDI84664.1 - 2.4 6.3 36.1 1.2 7.3 15.2 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Endostatin PF06482.11 CDI84664.1 - 2.8 7.3 26.5 3 7.2 5.9 2.4 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin SelP_N PF04592.14 CDI84664.1 - 3.3 7.0 38.5 0.4 10.0 21.9 2.6 2 0 0 2 2 2 0 Selenoprotein P, N terminal region SAPS PF04499.15 CDI84664.1 - 4.3 6.0 21.8 1.1 8.0 5.7 2.3 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein PIP5K PF01504.18 CDI84664.1 - 5.8 6.1 23.8 6.6 5.9 7.9 2.5 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase RIC3 PF15361.6 CDI84664.1 - 7.5 6.9 17.5 11 6.5 5.9 2.8 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 Nop14 PF04147.12 CDI84664.1 - 7.7 4.6 27.5 0.33 9.1 5.5 2.1 2 0 0 2 2 2 0 Nop14-like family ALMT PF11744.8 CDI84664.1 - 8.4 5.1 21.5 1.9 7.2 3.4 2.2 2 0 0 2 2 2 0 Aluminium activated malate transporter LAP1C PF05609.12 CDI84664.1 - 8.7 5.3 35.9 7.6 5.5 12.2 2.4 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Ndc1_Nup PF09531.10 CDI84664.1 - 9 4.8 29.9 2 7.0 7.5 2.3 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup DUF1269 PF06897.12 CDI84666.1 - 0.034 14.4 5.0 0.09 13.1 5.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) Romo1 PF10247.9 CDI84666.1 - 0.059 13.7 1.0 0.15 12.4 1.0 1.7 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 DUF3685 PF12452.8 CDI84666.1 - 0.097 12.4 0.2 0.2 11.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) DUF3587 PF12132.8 CDI84666.1 - 0.11 12.0 2.2 0.2 11.1 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3587) T2SSF PF00482.23 CDI84667.1 - 3.7 7.5 8.0 5.2 7.0 6.3 2.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F SLC12 PF03522.15 CDI84668.1 - 0.38 9.7 22.9 0.5 9.3 22.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Caldesmon PF02029.15 CDI84668.1 - 4.1 6.0 21.9 5.7 5.6 21.9 1.2 1 0 0 1 1 1 0 Caldesmon LAP1C PF05609.12 CDI84668.1 - 6.7 5.7 26.3 7.8 5.5 26.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GATase PF00117.28 CDI84669.1 - 0.013 15.3 0.3 0.014 15.2 0.3 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I RskA PF10099.9 CDI84670.1 - 4.5e-06 27.1 9.3 1.1e-05 25.8 9.3 1.5 1 1 0 1 1 1 1 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI84670.1 - 2.8e-05 23.1 9.2 3.5e-05 22.7 9.2 1.0 1 0 0 1 1 1 1 Presenilin eIF-3_zeta PF05091.12 CDI84670.1 - 2.9e-05 23.3 5.8 2.9e-05 23.3 5.8 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PIP5K PF01504.18 CDI84670.1 - 0.00053 19.3 2.2 0.00057 19.2 2.2 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF4834 PF16118.5 CDI84670.1 - 0.00063 20.7 11.9 0.00077 20.4 10.9 1.6 2 0 0 2 2 1 1 Domain of unknown function (DUF4834) SLC12 PF03522.15 CDI84670.1 - 0.0011 18.1 5.1 0.0012 18.0 5.1 1.1 1 0 0 1 1 1 1 Solute carrier family 12 SAPS PF04499.15 CDI84670.1 - 0.0018 17.2 3.8 0.002 17.0 3.8 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein PAT1 PF09770.9 CDI84670.1 - 0.0019 16.5 14.1 0.0021 16.4 14.1 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 CCDC53 PF10152.9 CDI84670.1 - 0.002 18.6 14.0 0.011 16.2 8.9 2.0 2 0 0 2 2 2 1 Subunit CCDC53 of WASH complex SID-1_RNA_chan PF13965.6 CDI84670.1 - 0.0023 16.4 1.6 0.0024 16.3 1.6 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Connexin PF00029.19 CDI84670.1 - 0.0025 17.6 6.6 0.0037 17.1 6.6 1.2 1 0 0 1 1 1 1 Connexin Hid1 PF12722.7 CDI84670.1 - 0.0034 15.6 3.9 0.003 15.8 3.9 1.1 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein AAA_23 PF13476.6 CDI84670.1 - 0.0035 17.9 9.9 0.0041 17.7 9.9 1.2 1 0 0 1 1 1 1 AAA domain Bac_luciferase PF00296.20 CDI84670.1 - 0.0061 16.0 5.8 0.0077 15.7 5.8 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase DUF4050 PF13259.6 CDI84670.1 - 0.0065 16.8 12.5 1.4 9.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4050) DUF4820 PF16091.5 CDI84670.1 - 0.0091 15.4 4.2 0.0091 15.4 4.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4820) CSG2 PF16965.5 CDI84670.1 - 0.0098 14.9 2.2 0.011 14.7 2.2 1.1 1 0 0 1 1 1 1 Ceramide synthase regulator TMEM214 PF10151.9 CDI84670.1 - 0.018 13.5 10.3 0.023 13.2 10.3 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator DUF2828 PF11443.8 CDI84670.1 - 0.062 11.4 10.2 0.087 10.9 10.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) G0-G1_switch_2 PF15103.6 CDI84670.1 - 0.062 13.7 11.6 0.07 13.6 9.0 2.0 2 0 0 2 2 2 0 G0/G1 switch protein 2 CLN3 PF02487.17 CDI84670.1 - 0.072 12.1 10.9 1.1 8.2 10.5 2.0 2 0 0 2 2 2 0 CLN3 protein Het-C PF07217.11 CDI84670.1 - 0.11 11.0 8.8 0.17 10.4 8.8 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C O-antigen_lig PF13425.6 CDI84670.1 - 0.11 11.2 2.4 0.14 11.0 2.4 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein FAM176 PF14851.6 CDI84670.1 - 0.17 11.6 8.3 0.32 10.6 8.3 1.4 1 0 0 1 1 1 0 FAM176 family Baculo_PP31 PF05311.11 CDI84670.1 - 0.19 11.2 9.4 0.31 10.5 9.4 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Rxt3 PF08642.10 CDI84670.1 - 0.2 12.4 7.1 0.28 11.9 5.4 1.9 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 Peroxin-13_N PF04088.13 CDI84670.1 - 0.22 11.8 6.0 0.32 11.3 4.8 1.7 2 0 0 2 2 2 0 Peroxin 13, N-terminal region TRAP_alpha PF03896.16 CDI84670.1 - 0.23 10.6 8.2 0.13 11.5 4.6 1.9 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit OATP PF03137.20 CDI84670.1 - 0.24 9.6 4.7 0.34 9.2 4.7 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Dynamin_N PF00350.23 CDI84670.1 - 0.29 11.2 4.8 0.43 10.6 4.8 1.3 1 0 0 1 1 1 0 Dynamin family DUF3405 PF11885.8 CDI84670.1 - 0.29 9.7 12.0 0.43 9.1 12.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) SpoIIP PF07454.11 CDI84670.1 - 0.3 10.5 17.9 0.028 13.9 13.6 1.4 2 0 0 2 2 1 0 Stage II sporulation protein P (SpoIIP) LMBR1 PF04791.16 CDI84670.1 - 0.32 9.9 3.0 0.32 9.9 3.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein EPL1 PF10513.9 CDI84670.1 - 0.33 11.3 15.6 1.8 8.9 16.1 1.8 2 0 0 2 2 2 0 Enhancer of polycomb-like Pex14_N PF04695.13 CDI84670.1 - 0.36 11.5 27.2 0.34 11.6 19.8 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region XAP5 PF04921.14 CDI84670.1 - 0.38 10.5 15.1 0.11 12.3 11.7 1.7 2 0 0 2 2 2 0 XAP5, circadian clock regulator PepSY_TM PF03929.16 CDI84670.1 - 0.44 10.2 10.9 6.5 6.3 0.0 2.0 2 0 0 2 2 2 0 PepSY-associated TM region DUF4637 PF15470.6 CDI84670.1 - 0.48 10.2 11.5 0.9 9.3 11.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Afi1 PF07792.12 CDI84670.1 - 0.5 10.9 16.0 0.93 10.0 16.0 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF3408 PF11888.8 CDI84670.1 - 0.74 10.0 19.0 0.098 12.8 14.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) V_ATPase_I PF01496.19 CDI84670.1 - 0.92 7.3 14.7 1.2 6.9 14.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AIF_C PF14721.6 CDI84670.1 - 1.2 9.5 17.0 0.5 10.7 10.5 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FYDLN_acid PF09538.10 CDI84670.1 - 1.2 9.8 13.6 0.29 11.8 5.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF5523 PF17661.1 CDI84670.1 - 1.3 8.7 20.0 0.35 10.5 17.2 1.4 2 0 0 2 2 1 0 Family of unknown function (DUF5523) CBP_BcsG PF11658.8 CDI84670.1 - 1.3 7.3 13.1 0.63 8.4 6.7 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG Tim54 PF11711.8 CDI84670.1 - 1.4 7.6 17.1 1.2 7.8 14.7 1.8 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 GNAT_acetyltr_2 PF13718.6 CDI84670.1 - 1.4 8.3 9.6 2.6 7.4 9.6 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DUF3391 PF11871.8 CDI84670.1 - 1.6 9.3 16.3 0.35 11.4 9.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) DUF4228 PF14009.6 CDI84670.1 - 1.6 9.1 10.1 2.4 8.5 5.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) Orf78 PF06024.12 CDI84670.1 - 1.8 8.9 10.2 1 9.7 6.2 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Folate_carrier PF01770.18 CDI84670.1 - 2.2 6.9 9.8 0.74 8.5 6.1 1.8 2 0 0 2 2 2 0 Reduced folate carrier TERB2 PF15101.6 CDI84670.1 - 2.3 8.2 22.1 4.2 7.4 22.1 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Otopetrin PF03189.13 CDI84670.1 - 2.5 6.8 7.2 4.1 6.1 7.2 1.3 1 0 0 1 1 1 0 Otopetrin DUF2126 PF09899.9 CDI84670.1 - 2.8 5.9 11.2 4.3 5.3 11.2 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF1764 PF08576.10 CDI84670.1 - 3.4 8.6 16.8 0.78 10.7 13.4 1.6 2 0 0 2 2 1 0 Eukaryotic protein of unknown function (DUF1764) DUF3464 PF11947.8 CDI84670.1 - 3.8 7.3 17.9 40 3.9 18.4 2.0 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 NEMP PF10225.9 CDI84670.1 - 4.1 7.0 4.8 6.2 6.4 4.8 1.3 1 0 0 1 1 1 0 NEMP family TraV PF09676.10 CDI84670.1 - 4.4 8.3 17.9 5.5 8.0 11.7 2.1 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) YqfQ PF14181.6 CDI84670.1 - 4.8 7.4 20.3 0.039 14.2 3.3 2.1 2 0 0 2 2 2 0 YqfQ-like protein DDRGK PF09756.9 CDI84670.1 - 5.3 6.6 25.5 7.3 6.1 25.5 1.2 1 0 0 1 1 1 0 DDRGK domain DUF4628 PF15429.6 CDI84670.1 - 5.6 6.5 15.5 7.5 6.1 13.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4628) ALMT PF11744.8 CDI84670.1 - 6.2 5.5 12.1 9.6 4.9 12.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec62 PF03839.16 CDI84670.1 - 6.8 6.1 13.1 11 5.4 13.1 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Paf1 PF03985.13 CDI84670.1 - 7.2 5.5 25.1 11 4.9 25.1 1.1 1 0 0 1 1 1 0 Paf1 Kei1 PF08552.11 CDI84670.1 - 7.2 6.4 18.0 7.5 6.4 9.4 2.1 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Band_3_cyto PF07565.13 CDI84670.1 - 7.3 6.3 15.5 12 5.6 15.5 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Ureide_permease PF07168.11 CDI84670.1 - 7.9 5.1 10.2 0.064 12.0 2.2 1.5 2 0 0 2 2 1 0 Ureide permease MDM10 PF12519.8 CDI84670.1 - 8.3 5.2 15.2 13 4.6 15.2 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF1980 PF09323.10 CDI84670.1 - 9.3 6.1 16.2 3.5 7.5 13.6 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF1980) DUF572 PF04502.13 CDI84671.1 - 0.81 9.3 18.3 1 8.9 18.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) TCP PF03634.13 CDI84671.1 - 1.2 9.7 21.9 1.2 9.7 10.8 2.1 2 0 0 2 2 2 0 TCP family transcription factor DUF2721 PF11026.8 CDI84671.1 - 8.6 6.3 14.7 0.046 13.6 5.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) SID-1_RNA_chan PF13965.6 CDI84671.1 - 9.9 4.4 11.6 12 4.2 11.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Bul1_N PF04425.12 CDI84672.1 - 0.52 9.0 12.2 0.58 8.8 12.2 1.0 1 0 0 1 1 1 0 Bul1 N terminus Gti1_Pac2 PF09729.9 CDI84672.1 - 1.1 9.4 12.9 1.1 9.3 12.9 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family Presenilin PF01080.17 CDI84672.1 - 1.4 7.6 12.6 1.5 7.5 12.6 1.0 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 CDI84672.1 - 1.8 7.3 4.1 2 7.1 4.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Striatin PF08232.12 CDI84672.1 - 1.8 9.2 9.0 2 9.0 9.0 1.1 1 0 0 1 1 1 0 Striatin family Alpha_GJ PF03229.13 CDI84672.1 - 2.9 8.5 6.3 3.8 8.1 6.3 1.3 1 0 0 1 1 1 0 Alphavirus glycoprotein J Otopetrin PF03189.13 CDI84672.1 - 3.9 6.2 8.4 4.4 6.0 8.4 1.0 1 0 0 1 1 1 0 Otopetrin NPR3 PF03666.13 CDI84672.1 - 4.2 6.0 15.7 4.6 5.9 15.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3362 PF11842.8 CDI84672.1 - 4.3 7.7 8.6 4.5 7.6 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3362) DUF5102 PF17104.5 CDI84672.1 - 4.5 7.2 10.8 5.4 7.0 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) Apt1 PF10351.9 CDI84672.1 - 4.9 5.9 24.8 5.2 5.8 24.8 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ctr PF04145.15 CDI84672.1 - 5.6 7.6 6.5 7.6 7.1 6.5 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Pex14_N PF04695.13 CDI84672.1 - 5.7 7.6 12.7 6.9 7.3 12.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ASD2 PF08687.11 CDI84672.1 - 6 6.3 7.9 6.6 6.2 7.9 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Macoilin PF09726.9 CDI84672.1 - 6.5 5.2 29.5 7 5.1 29.5 1.0 1 0 0 1 1 1 0 Macoilin family Raftlin PF15250.6 CDI84672.1 - 7.1 5.3 10.5 8 5.1 10.5 1.0 1 0 0 1 1 1 0 Raftlin Zip PF02535.22 CDI84672.1 - 7.7 5.6 9.2 8.6 5.5 9.2 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 CDI84672.1 - 9.3 4.5 15.9 10 4.4 15.9 1.0 1 0 0 1 1 1 0 Menin SpoIIP PF07454.11 CDI84673.1 - 0.024 14.1 18.2 0.024 14.1 18.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) eIF-3_zeta PF05091.12 CDI84673.1 - 0.12 11.3 25.5 0.13 11.2 25.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) O-antigen_lig PF13425.6 CDI84673.1 - 0.13 11.0 7.1 0.14 10.9 7.1 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Ctr PF04145.15 CDI84673.1 - 0.14 12.8 9.2 0.2 12.3 9.2 1.3 1 0 0 1 1 1 0 Ctr copper transporter family SID-1_RNA_chan PF13965.6 CDI84673.1 - 0.15 10.4 7.0 0.16 10.4 7.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CDC45 PF02724.14 CDI84673.1 - 0.21 9.8 14.7 0.22 9.8 14.7 1.0 1 0 0 1 1 1 0 CDC45-like protein CSRNP_N PF16019.5 CDI84673.1 - 0.33 10.8 17.1 0.4 10.6 17.1 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Band_3_cyto PF07565.13 CDI84673.1 - 0.34 10.7 17.5 0.38 10.5 17.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain AAA_23 PF13476.6 CDI84673.1 - 0.37 11.3 20.6 0.4 11.2 20.6 1.2 1 0 0 1 1 1 0 AAA domain Lin-8 PF03353.15 CDI84673.1 - 0.39 10.2 24.5 0.4 10.2 24.5 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist FAM60A PF15396.6 CDI84673.1 - 0.43 10.5 13.7 0.52 10.3 13.7 1.3 1 0 0 1 1 1 0 Protein Family FAM60A CLN3 PF02487.17 CDI84673.1 - 0.44 9.5 14.0 0.45 9.5 14.0 1.1 1 0 0 1 1 1 0 CLN3 protein Endostatin PF06482.11 CDI84673.1 - 0.45 9.9 20.0 0.49 9.8 20.0 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin BAF1_ABF1 PF04684.13 CDI84673.1 - 0.51 9.3 22.4 0.6 9.1 22.4 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4746 PF15928.5 CDI84673.1 - 0.56 9.6 13.4 0.61 9.5 13.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) ALMT PF11744.8 CDI84673.1 - 0.58 8.9 14.1 0.56 9.0 14.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter RR_TM4-6 PF06459.12 CDI84673.1 - 0.66 9.7 22.0 0.7 9.7 22.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tfb4 PF03850.14 CDI84673.1 - 0.72 9.3 12.5 0.76 9.2 12.5 1.1 1 0 0 1 1 1 0 Transcription factor Tfb4 NARP1 PF12569.8 CDI84673.1 - 0.72 8.7 19.6 0.77 8.6 19.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 GET2 PF08690.10 CDI84673.1 - 0.94 9.1 25.8 1.1 8.9 25.8 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 Presenilin PF01080.17 CDI84673.1 - 0.97 8.1 28.2 1.1 8.0 28.2 1.0 1 0 0 1 1 1 0 Presenilin DUF2828 PF11443.8 CDI84673.1 - 0.98 7.4 20.1 1 7.4 20.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Peptidase_S49_N PF08496.10 CDI84673.1 - 1 9.4 16.5 1.4 9.0 16.5 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PA26 PF04636.13 CDI84673.1 - 1 8.2 14.4 1.1 8.1 14.4 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Gti1_Pac2 PF09729.9 CDI84673.1 - 1 9.4 17.0 1.2 9.2 17.0 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Neur_chan_memb PF02932.16 CDI84673.1 - 1 9.3 16.8 1.1 9.3 16.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EIF4E-T PF10477.9 CDI84673.1 - 1.1 8.0 27.6 1.2 7.9 27.6 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Paf1 PF03985.13 CDI84673.1 - 1.1 8.2 22.9 1.2 8.0 22.9 1.1 1 0 0 1 1 1 0 Paf1 PPL5 PF18168.1 CDI84673.1 - 1.1 8.5 14.2 1.2 8.3 14.2 1.1 1 0 0 1 1 1 0 Prim-pol family 5 SLC12 PF03522.15 CDI84673.1 - 1.1 8.1 21.8 1.1 8.3 21.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SpoVR PF04293.13 CDI84673.1 - 1.2 7.7 14.0 1.3 7.7 14.0 1.1 1 0 0 1 1 1 0 SpoVR like protein BORG_CEP PF14957.6 CDI84673.1 - 1.2 10.3 15.0 1.4 10.1 15.0 1.2 1 0 0 1 1 1 0 Cdc42 effector Peptidase_S15 PF02129.18 CDI84673.1 - 1.3 8.6 19.5 1.5 8.4 19.5 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF913 PF06025.12 CDI84673.1 - 1.3 7.9 14.9 1.4 7.8 14.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) IHABP4_N PF16174.5 CDI84673.1 - 1.3 9.6 32.2 1.6 9.3 32.2 1.1 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal DUF2126 PF09899.9 CDI84673.1 - 1.4 6.9 15.6 1.5 6.8 15.6 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DDHD PF02862.17 CDI84673.1 - 1.4 9.0 20.5 1.9 8.6 20.5 1.3 1 0 0 1 1 1 0 DDHD domain Velvet PF11754.8 CDI84673.1 - 1.4 8.8 22.4 1.7 8.5 22.4 1.1 1 0 0 1 1 1 0 Velvet factor NEMP PF10225.9 CDI84673.1 - 1.6 8.4 6.9 1.8 8.2 6.9 1.1 1 0 0 1 1 1 0 NEMP family Pal1 PF08316.11 CDI84673.1 - 1.6 9.5 11.8 2 9.2 11.8 1.2 1 0 0 1 1 1 0 Pal1 cell morphology protein MMU163 PF17119.5 CDI84673.1 - 1.6 7.9 8.8 2 7.5 8.8 1.4 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Membralin PF09746.9 CDI84673.1 - 1.6 7.7 12.6 1.8 7.5 12.6 1.1 1 0 0 1 1 1 0 Tumour-associated protein Baculo_PP31 PF05311.11 CDI84673.1 - 1.7 8.1 16.8 1.9 7.9 16.8 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) CCSAP PF15748.5 CDI84673.1 - 1.7 8.8 25.2 1.9 8.6 25.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PAT1 PF09770.9 CDI84673.1 - 1.8 6.7 40.3 1.9 6.6 40.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 CDI84673.1 - 1.8 8.5 60.2 2.2 8.2 60.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit API5 PF05918.11 CDI84673.1 - 1.8 7.2 20.3 2.1 7.1 20.3 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Nop53 PF07767.11 CDI84673.1 - 2 7.7 28.1 2.2 7.6 28.1 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) XRN_M PF17846.1 CDI84673.1 - 2.1 7.2 12.7 2.1 7.2 12.7 1.2 1 0 0 1 1 1 0 Xrn1 helical domain DUF4637 PF15470.6 CDI84673.1 - 2.2 8.0 12.7 2.9 7.6 12.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) FAM176 PF14851.6 CDI84673.1 - 2.3 7.9 12.7 3.2 7.4 12.7 1.3 1 0 0 1 1 1 0 FAM176 family NPR3 PF03666.13 CDI84673.1 - 2.3 6.9 20.1 2.6 6.7 20.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Tim54 PF11711.8 CDI84673.1 - 2.4 6.9 19.8 2.8 6.7 19.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TCP PF03634.13 CDI84673.1 - 2.5 8.7 22.4 3.1 8.4 22.4 1.2 1 0 0 1 1 1 0 TCP family transcription factor MDM10 PF12519.8 CDI84673.1 - 2.6 6.8 17.0 2.8 6.7 17.0 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Bac_luciferase PF00296.20 CDI84673.1 - 2.8 7.3 14.7 3.1 7.1 14.7 1.0 1 0 0 1 1 1 0 Luciferase-like monooxygenase HemX PF04375.14 CDI84673.1 - 2.9 7.1 45.1 3.4 6.9 45.1 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase MDM31_MDM32 PF08118.11 CDI84673.1 - 3 6.4 11.5 3.5 6.2 11.5 1.3 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Connexin PF00029.19 CDI84673.1 - 3.1 7.5 17.4 3.8 7.2 17.4 1.1 1 0 0 1 1 1 0 Connexin BBL5 PF07289.11 CDI84673.1 - 3.3 6.7 12.6 3.8 6.5 12.6 1.1 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein Scs3p PF10261.9 CDI84673.1 - 3.3 7.1 6.3 3.5 7.1 6.3 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM OATP PF03137.20 CDI84673.1 - 3.3 5.9 9.9 3.8 5.7 9.9 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Sec62 PF03839.16 CDI84673.1 - 3.6 7.0 17.3 4.6 6.7 17.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 MAJIN PF15077.6 CDI84673.1 - 3.9 7.2 17.7 4.2 7.1 17.7 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein HCO3_cotransp PF00955.21 CDI84673.1 - 4 6.1 9.2 4.4 6.0 9.2 1.0 1 0 0 1 1 1 0 HCO3- transporter family Serinc PF03348.15 CDI84673.1 - 4.1 6.2 14.2 4.4 6.1 14.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) MgsA_C PF12002.8 CDI84673.1 - 4.5 7.2 16.3 5.2 7.0 16.3 1.1 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal Hid1 PF12722.7 CDI84673.1 - 4.8 5.2 22.2 4.7 5.2 22.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Smg8_Smg9 PF10220.9 CDI84673.1 - 4.8 5.4 22.1 5.2 5.3 22.1 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Cellulose_synt PF03552.14 CDI84673.1 - 5 5.5 8.2 5.3 5.4 8.2 1.0 1 0 0 1 1 1 0 Cellulose synthase DUF2072 PF09845.9 CDI84673.1 - 5.6 7.2 13.9 6.5 7.0 13.9 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein Macoilin PF09726.9 CDI84673.1 - 5.9 5.3 20.0 7.1 5.1 20.0 1.2 1 0 0 1 1 1 0 Macoilin family Pannexin_like PF12534.8 CDI84673.1 - 6 5.8 15.8 7.1 5.6 15.8 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 CSG2 PF16965.5 CDI84673.1 - 6.2 5.7 12.4 6.9 5.5 12.4 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Hamartin PF04388.12 CDI84673.1 - 6.7 5.3 21.3 6.8 5.2 21.3 1.0 1 0 0 1 1 1 0 Hamartin protein DUF4228 PF14009.6 CDI84673.1 - 7 7.0 17.0 10 6.5 17.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Mem_trans PF03547.18 CDI84673.1 - 7.3 4.9 5.3 7.3 4.9 5.3 1.2 1 0 0 1 1 1 0 Membrane transport protein Glyco_transf_41 PF13844.6 CDI84673.1 - 7.4 4.9 11.3 7.9 4.8 11.3 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 Peptidase_S64 PF08192.11 CDI84673.1 - 8 4.8 20.1 9.1 4.6 20.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 TFB6 PF17110.5 CDI84673.1 - 8.1 6.2 12.2 12 5.6 12.2 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF572 PF04502.13 CDI84673.1 - 8.6 5.9 22.4 9.2 5.8 22.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) FliP PF00813.20 CDI84673.1 - 8.8 6.2 9.2 8.4 6.2 9.2 1.1 1 0 0 1 1 1 0 FliP family MMR1 PF08505.10 CDI84673.1 - 8.9 6.5 28.5 11 6.3 28.5 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Paramyxo_ncap PF00973.19 CDI84673.1 - 10 4.9 17.0 10 4.9 17.0 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein SR-25 PF10500.9 CDI84674.1 - 0.0068 16.0 25.1 0.0068 16.0 25.1 2.1 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein CCSAP PF15748.5 CDI84674.1 - 0.083 13.1 44.7 0.1 12.7 44.7 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF5523 PF17661.1 CDI84674.1 - 1.3 8.6 29.9 2.1 8.0 29.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5523) AAA_23 PF13476.6 CDI84674.1 - 2.3 8.7 30.2 2.9 8.4 30.2 1.1 1 0 0 1 1 1 0 AAA domain Caldesmon PF02029.15 CDI84674.1 - 5.2 5.7 36.4 7 5.3 36.4 1.1 1 0 0 1 1 1 0 Caldesmon DUF4834 PF16118.5 CDI84675.1 - 8e-05 23.5 24.8 0.026 15.5 2.6 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF4834) CLN3 PF02487.17 CDI84675.1 - 0.0069 15.5 13.8 0.19 10.7 0.8 3.1 3 0 0 3 3 3 3 CLN3 protein Peptidase_S49_N PF08496.10 CDI84675.1 - 0.0096 16.0 22.0 0.49 10.5 0.7 3.2 3 0 0 3 3 3 3 Peptidase family S49 N-terminal DUF719 PF05334.13 CDI84675.1 - 0.1 12.8 17.4 0.27 11.4 1.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF719) HA2 PF04408.23 CDI84675.1 - 0.12 12.7 13.3 0.43 10.9 0.8 3.6 3 0 0 3 3 3 0 Helicase associated domain (HA2) TFIIA PF03153.13 CDI84675.1 - 0.14 12.2 85.3 0.23 11.4 31.0 3.0 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit SID-1_RNA_chan PF13965.6 CDI84675.1 - 0.18 10.2 6.7 2.9 6.2 0.1 2.9 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 MMM1 PF10296.9 CDI84675.1 - 0.45 9.5 10.7 0.77 8.7 0.3 2.9 3 0 0 3 3 3 0 Maintenance of mitochondrial morphology protein 1 FHIPEP PF00771.20 CDI84675.1 - 0.61 8.5 22.3 0.55 8.6 1.4 3.0 3 0 0 3 3 3 0 FHIPEP family RR_TM4-6 PF06459.12 CDI84675.1 - 0.68 9.7 17.6 0.27 11.0 1.9 3.0 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 RskA PF10099.9 CDI84675.1 - 0.82 9.9 73.1 0.17 12.2 13.2 4.8 1 1 3 4 4 3 0 Anti-sigma-K factor rskA Nucleoside_tran PF01733.18 CDI84675.1 - 1.1 8.6 8.6 1.6 8.0 0.1 3.2 3 0 0 3 3 3 0 Nucleoside transporter Peroxin-13_N PF04088.13 CDI84675.1 - 1.2 9.4 15.6 1.3 9.2 1.1 3.2 3 0 0 3 3 3 0 Peroxin 13, N-terminal region Spt20 PF12090.8 CDI84675.1 - 1.7 8.2 92.5 0.13 11.9 20.3 3.1 3 0 0 3 3 3 0 Spt20 family CPSF100_C PF13299.6 CDI84675.1 - 1.9 8.6 19.6 1.2 9.3 3.3 3.3 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Renin_r PF07850.14 CDI84675.1 - 2.4 8.8 10.9 5.9 7.6 0.1 3.3 3 0 0 3 3 3 0 Renin receptor-like protein DUF572 PF04502.13 CDI84675.1 - 2.7 7.5 24.1 0.21 11.2 0.2 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF572) AIF_C PF14721.6 CDI84675.1 - 2.7 8.3 19.9 9.8 6.5 2.8 3.2 3 0 0 3 3 3 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FAM176 PF14851.6 CDI84675.1 - 3.3 7.4 18.4 1.5 8.4 3.1 3.2 3 0 0 3 3 3 0 FAM176 family Dala_Dala_lig_N PF01820.21 CDI84675.1 - 3.6 8.1 4.6 25 5.4 0.0 2.8 3 0 0 3 3 3 0 D-ala D-ala ligase N-terminus G0-G1_switch_2 PF15103.6 CDI84675.1 - 3.7 8.0 22.2 0.3 11.5 2.2 3.3 3 0 0 3 3 3 0 G0/G1 switch protein 2 FctA PF12892.7 CDI84675.1 - 3.9 8.3 6.6 12 6.7 0.5 2.6 2 0 0 2 2 2 0 Spy0128-like isopeptide containing domain MCU PF04678.13 CDI84675.1 - 4.7 7.3 21.9 1.4 9.0 1.6 3.3 3 0 0 3 3 3 0 Mitochondrial calcium uniporter DUF5327 PF17261.2 CDI84675.1 - 5.4 7.8 42.6 0.84 10.4 11.9 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5327) YABBY PF04690.13 CDI84675.1 - 6.7 7.3 25.1 9.7 6.7 2.8 3.2 3 0 0 3 3 3 0 YABBY protein EOS1 PF12326.8 CDI84675.1 - 9.2 6.2 15.3 1.3 8.9 0.1 2.8 2 1 0 2 2 2 0 N-glycosylation protein V_ATPase_I PF01496.19 CDI84675.1 - 9.9 3.9 24.1 2 6.3 1.8 3.0 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family Ribosomal_60s PF00428.19 CDI84676.1 - 0.066 13.8 22.1 0.68 10.6 2.3 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein CwsA PF10814.8 CDI84677.1 - 0.48 10.6 6.3 10 6.3 0.0 2.4 1 1 0 2 2 2 0 Cell wall synthesis protein CwsA SUIM_assoc PF16619.5 CDI84677.1 - 7.6 6.7 27.7 7.1 6.8 5.3 3.3 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 CRAL_TRIO PF00650.20 CDI84678.1 - 0.0017 18.1 0.0 0.0029 17.4 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain FEZ PF07763.13 CDI84678.1 - 0.0042 16.9 0.4 0.0075 16.0 0.4 1.3 1 0 0 1 1 1 1 FEZ-like protein Tau95 PF09734.9 CDI84678.1 - 0.13 13.1 0.8 3.9 8.3 0.3 2.6 1 1 1 2 2 2 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain DUF2151 PF10221.9 CDI84678.1 - 0.16 10.5 0.3 0.21 10.1 0.3 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator XRCC4 PF06632.12 CDI84680.1 - 0.065 12.1 17.0 0.069 12.0 17.0 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 CLP_protease PF00574.23 CDI84680.1 - 0.33 10.8 8.3 0.37 10.7 8.3 1.1 1 0 0 1 1 1 0 Clp protease SID-1_RNA_chan PF13965.6 CDI84680.1 - 0.62 8.4 6.5 0.55 8.6 6.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Myc_N PF01056.18 CDI84680.1 - 0.7 9.7 16.8 0.8 9.5 16.8 1.0 1 0 0 1 1 1 0 Myc amino-terminal region TFB6 PF17110.5 CDI84680.1 - 0.85 9.3 9.5 1 9.1 9.5 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH TraT PF05818.12 CDI84680.1 - 1 9.0 16.6 1.1 8.9 16.6 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Glt_symporter PF03616.14 CDI84680.1 - 1.1 7.8 5.1 1.3 7.6 5.1 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter Spt20 PF12090.8 CDI84680.1 - 1.2 8.7 41.9 1.5 8.4 41.9 1.3 1 0 0 1 1 1 0 Spt20 family Endostatin PF06482.11 CDI84680.1 - 1.3 8.4 16.3 1.3 8.5 16.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin eIF-3_zeta PF05091.12 CDI84680.1 - 1.5 7.7 22.3 1.5 7.7 22.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI84680.1 - 1.9 8.4 45.6 2 8.3 45.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1980 PF09323.10 CDI84680.1 - 2 8.3 11.1 2.3 8.1 11.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) ECM1 PF05782.11 CDI84680.1 - 2.2 7.1 20.3 2.4 7.0 20.3 1.0 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) RskA PF10099.9 CDI84680.1 - 2.4 8.4 33.4 4.3 7.6 33.4 1.5 1 1 0 1 1 1 0 Anti-sigma-K factor rskA MMR1 PF08505.10 CDI84680.1 - 2.5 8.3 24.0 2.6 8.3 24.0 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DcuA_DcuB PF03605.14 CDI84680.1 - 3 6.6 5.4 3.8 6.3 5.4 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter SprA-related PF12118.8 CDI84680.1 - 3.1 6.9 38.6 3.3 6.7 38.6 1.1 1 0 0 1 1 1 0 SprA-related family BORG_CEP PF14957.6 CDI84680.1 - 3.1 9.0 12.7 3.3 8.9 12.7 1.2 1 0 0 1 1 1 0 Cdc42 effector Cellulose_synt PF03552.14 CDI84680.1 - 3.8 5.9 8.8 4 5.8 8.8 1.0 1 0 0 1 1 1 0 Cellulose synthase RR_TM4-6 PF06459.12 CDI84680.1 - 4.5 7.0 23.5 4.8 6.9 23.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CSG2 PF16965.5 CDI84680.1 - 4.7 6.1 9.0 4.3 6.2 9.0 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Serinc PF03348.15 CDI84680.1 - 4.9 6.0 11.5 4.8 6.0 11.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) FAM60A PF15396.6 CDI84680.1 - 5.3 7.0 16.5 5.9 6.8 16.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF1682 PF07946.14 CDI84680.1 - 5.4 6.1 20.8 6.6 5.8 20.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) PGA_cap PF09587.10 CDI84680.1 - 6.1 6.2 12.5 7.6 5.9 12.5 1.1 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap SLC12 PF03522.15 CDI84680.1 - 6.5 5.7 18.5 6.2 5.7 18.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI84680.1 - 6.9 6.6 14.7 7 6.6 14.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.17 CDI84680.1 - 8.5 6.5 18.2 9.6 6.3 18.2 1.1 1 0 0 1 1 1 0 DDHD domain SpoIIP PF07454.11 CDI84680.1 - 9 5.7 21.8 10 5.5 21.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TERB2 PF15101.6 CDI84680.1 - 9.5 6.2 23.9 11 6.0 23.9 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SR-25 PF10500.9 CDI84681.1 - 0.00024 20.8 16.1 0.00034 20.3 16.1 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein BRF1 PF07741.13 CDI84681.1 - 0.0012 19.1 12.4 0.0015 18.8 12.4 1.2 1 0 0 1 1 1 1 Brf1-like TBP-binding domain RPA43_OB PF17875.1 CDI84681.1 - 0.0062 17.2 13.0 0.0072 17.0 13.0 1.1 1 0 0 1 1 1 1 RPA43 OB domain in RNA Pol I Acetate_kinase PF00871.17 CDI84681.1 - 0.028 13.1 2.6 0.032 12.9 2.6 1.0 1 0 0 1 1 1 0 Acetokinase family CCDC53 PF10152.9 CDI84681.1 - 0.036 14.5 14.7 0.037 14.5 14.7 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex eIF-3_zeta PF05091.12 CDI84681.1 - 0.067 12.2 23.6 0.072 12.1 23.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DevR PF01905.16 CDI84681.1 - 0.076 12.1 5.9 0.089 11.8 5.9 1.1 1 0 0 1 1 1 0 CRISPR-associated negative auto-regulator DevR/Csa2 DUF3408 PF11888.8 CDI84681.1 - 0.092 12.9 16.3 0.11 12.6 16.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Connexin PF00029.19 CDI84681.1 - 0.16 11.7 14.3 0.18 11.6 14.3 1.1 1 0 0 1 1 1 0 Connexin SpoIIP PF07454.11 CDI84681.1 - 0.21 11.0 18.9 0.23 10.9 18.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) XRN_M PF17846.1 CDI84681.1 - 0.23 10.4 11.6 0.26 10.2 11.6 1.0 1 0 0 1 1 1 0 Xrn1 helical domain FAM199X PF15814.5 CDI84681.1 - 0.23 10.5 14.2 0.29 10.1 14.2 1.1 1 0 0 1 1 1 0 Protein family FAM199X Presenilin PF01080.17 CDI84681.1 - 0.28 9.9 23.7 0.29 9.9 23.7 1.0 1 0 0 1 1 1 0 Presenilin CCSAP PF15748.5 CDI84681.1 - 0.3 11.2 22.7 0.36 11.0 22.7 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated RR_TM4-6 PF06459.12 CDI84681.1 - 0.33 10.8 17.5 0.35 10.7 17.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TERB2 PF15101.6 CDI84681.1 - 0.37 10.8 24.3 0.44 10.6 24.3 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TFB6 PF17110.5 CDI84681.1 - 0.37 10.5 11.4 0.43 10.3 11.4 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DDHD PF02862.17 CDI84681.1 - 0.57 10.3 19.4 0.66 10.1 19.4 1.1 1 0 0 1 1 1 0 DDHD domain SOBP PF15279.6 CDI84681.1 - 0.6 10.7 21.1 0.67 10.5 21.1 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Serinc PF03348.15 CDI84681.1 - 0.61 9.0 13.8 0.78 8.6 13.8 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Spc7_N PF15402.6 CDI84681.1 - 0.63 8.2 19.6 0.74 8.0 19.6 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Kei1 PF08552.11 CDI84681.1 - 0.63 9.9 13.2 0.7 9.7 13.2 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 FAM176 PF14851.6 CDI84681.1 - 0.69 9.6 11.3 0.94 9.1 11.3 1.2 1 0 0 1 1 1 0 FAM176 family Folate_carrier PF01770.18 CDI84681.1 - 0.76 8.4 10.4 0.78 8.4 10.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier TCP PF03634.13 CDI84681.1 - 0.77 10.3 22.0 0.95 10.0 22.0 1.1 1 0 0 1 1 1 0 TCP family transcription factor SLC12 PF03522.15 CDI84681.1 - 0.78 8.7 19.9 0.87 8.5 19.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SID-1_RNA_chan PF13965.6 CDI84681.1 - 0.78 8.1 11.0 0.85 7.9 11.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF913 PF06025.12 CDI84681.1 - 0.87 8.5 11.7 0.93 8.4 11.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2448 PF10476.9 CDI84681.1 - 0.93 9.3 3.2 1.1 9.1 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) FYDLN_acid PF09538.10 CDI84681.1 - 1.1 10.0 8.9 1.5 9.5 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) V_ATPase_I PF01496.19 CDI84681.1 - 1.2 7.0 21.0 1.3 6.8 21.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Zip PF02535.22 CDI84681.1 - 1.2 8.3 17.3 1.2 8.3 17.3 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2828 PF11443.8 CDI84681.1 - 1.3 7.0 18.6 1.4 6.9 18.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) TFIIA PF03153.13 CDI84681.1 - 1.3 8.9 47.6 1.7 8.5 47.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sec62 PF03839.16 CDI84681.1 - 1.6 8.2 14.5 1.8 8.0 14.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Paf1 PF03985.13 CDI84681.1 - 1.7 7.6 21.2 1.8 7.4 21.2 1.1 1 0 0 1 1 1 0 Paf1 DUF4746 PF15928.5 CDI84681.1 - 1.7 8.0 13.6 1.9 7.8 13.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PAT1 PF09770.9 CDI84681.1 - 1.7 6.8 31.5 1.8 6.7 31.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Plasmodium_Vir PF05795.11 CDI84681.1 - 1.7 8.0 16.2 2 7.8 16.2 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CPSF100_C PF13299.6 CDI84681.1 - 1.8 8.7 14.5 2.1 8.5 14.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Endostatin PF06482.11 CDI84681.1 - 2 7.8 21.5 2.3 7.6 21.5 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Peptidase_S49_N PF08496.10 CDI84681.1 - 2.4 8.2 18.5 2.8 8.0 18.5 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MMR1 PF08505.10 CDI84681.1 - 2.5 8.3 29.9 3.1 8.0 29.9 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF1645 PF07816.11 CDI84681.1 - 2.5 8.7 23.1 4 8.0 23.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1645) AIF_C PF14721.6 CDI84681.1 - 2.5 8.5 19.0 2 8.8 17.9 1.4 1 1 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Tim54 PF11711.8 CDI84681.1 - 2.6 6.7 17.2 3.1 6.5 17.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CLN3 PF02487.17 CDI84681.1 - 2.7 7.0 16.5 3 6.8 16.5 1.1 1 0 0 1 1 1 0 CLN3 protein Pex14_N PF04695.13 CDI84681.1 - 2.8 8.6 32.8 4.1 8.0 32.8 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MDM10 PF12519.8 CDI84681.1 - 2.9 6.6 16.9 3.2 6.5 16.9 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SprA-related PF12118.8 CDI84681.1 - 3.5 6.7 36.5 4.7 6.3 36.5 1.2 1 0 0 1 1 1 0 SprA-related family MAP17 PF15807.5 CDI84681.1 - 3.6 7.8 14.0 4.9 7.4 14.0 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF2126 PF09899.9 CDI84681.1 - 4.5 5.2 14.7 4.9 5.1 14.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Ureide_permease PF07168.11 CDI84681.1 - 4.6 5.9 9.1 5 5.8 9.1 1.2 1 0 0 1 1 1 0 Ureide permease Neur_chan_memb PF02932.16 CDI84681.1 - 4.9 7.1 17.2 5.7 6.9 17.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF853 PF05872.12 CDI84681.1 - 5.2 5.5 13.5 5.6 5.4 13.5 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Tmem26 PF09772.9 CDI84681.1 - 5.7 6.2 11.6 6.9 5.9 11.6 1.1 1 0 0 1 1 1 0 Transmembrane protein 26 DUF5524 PF17662.1 CDI84681.1 - 5.9 6.2 16.8 6.8 6.0 16.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5524) CSG2 PF16965.5 CDI84681.1 - 6 5.7 13.1 6.4 5.6 13.1 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4638 PF15472.6 CDI84681.1 - 6.2 6.5 16.8 7.6 6.2 16.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) CAC1F_C PF16885.5 CDI84681.1 - 6.4 6.3 16.5 7.5 6.1 16.5 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term CDC45 PF02724.14 CDI84681.1 - 6.5 4.9 18.7 7.2 4.8 18.7 1.0 1 0 0 1 1 1 0 CDC45-like protein ALMT PF11744.8 CDI84681.1 - 6.6 5.4 18.2 7.4 5.3 18.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Membralin PF09746.9 CDI84681.1 - 6.8 5.6 16.0 7.6 5.5 16.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein NEMP PF10225.9 CDI84681.1 - 7 6.2 10.5 8 6.1 10.5 1.2 1 0 0 1 1 1 0 NEMP family Velvet PF11754.8 CDI84681.1 - 8 6.3 26.7 9.8 6.0 26.7 1.1 1 0 0 1 1 1 0 Velvet factor EOS1 PF12326.8 CDI84681.1 - 8.4 6.3 16.0 12 5.8 16.0 1.3 1 0 0 1 1 1 0 N-glycosylation protein FHIPEP PF00771.20 CDI84681.1 - 8.6 4.7 11.3 10 4.4 11.3 1.2 1 0 0 1 1 1 0 FHIPEP family PPL5 PF18168.1 CDI84681.1 - 8.7 5.5 16.4 9.8 5.4 16.4 1.1 1 0 0 1 1 1 0 Prim-pol family 5 CobT PF06213.12 CDI84681.1 - 8.8 5.6 28.0 10 5.4 28.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT LpxB PF02684.15 CDI84681.1 - 9.7 4.9 15.1 11 4.8 15.1 1.0 1 0 0 1 1 1 0 Lipid-A-disaccharide synthetase Presenilin PF01080.17 CDI84682.1 - 0.094 11.5 62.5 0.2 10.4 14.7 3.0 3 0 0 3 3 3 0 Presenilin BORG_CEP PF14957.6 CDI84682.1 - 0.83 10.8 39.2 3.9 8.6 15.7 3.3 3 0 0 3 3 3 0 Cdc42 effector TCP PF03634.13 CDI84682.1 - 2.3 8.7 51.4 4.4 7.8 0.6 3.3 3 0 0 3 3 3 0 TCP family transcription factor DUF1654 PF07867.11 CDI84683.1 - 0.00016 21.4 0.2 0.62 9.8 0.0 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF1654) GIDA PF01134.22 CDI84684.1 - 1.3e-06 27.7 0.1 1.3e-06 27.7 0.1 3.2 3 0 0 3 3 3 2 Glucose inhibited division protein A SR-25 PF10500.9 CDI84684.1 - 0.00022 20.9 2.0 0.00022 20.9 2.0 6.1 5 1 1 6 6 6 1 Nuclear RNA-splicing-associated protein PAP1 PF08601.10 CDI84684.1 - 0.00048 20.0 9.2 0.00048 20.0 9.2 3.4 1 1 2 3 3 3 1 Transcription factor PAP1 DUF2207 PF09972.9 CDI84684.1 - 0.015 14.1 4.4 3.8 6.2 0.1 3.4 3 1 0 3 3 3 0 Predicted membrane protein (DUF2207) DUF2946 PF11162.8 CDI84684.1 - 0.032 14.9 0.3 0.032 14.9 0.3 5.3 4 1 2 6 6 6 0 Protein of unknown function (DUF2946) DUF3040 PF11239.8 CDI84684.1 - 0.097 12.9 1.6 1.3 9.4 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) CrgA PF06781.12 CDI84684.1 - 0.39 10.8 0.1 0.39 10.8 0.1 5.4 6 1 0 6 6 6 0 Cell division protein CrgA Consortin_C PF15281.6 CDI84684.1 - 1.1 9.2 0.0 1.1 9.2 0.0 5.2 4 1 1 5 5 5 0 Consortin C-terminus Coiled PF05710.12 CDI84684.1 - 3.3 8.6 39.7 0.3 11.9 1.7 3.4 3 0 0 3 3 3 0 Coiled coil AUX_IAA PF02309.16 CDI84685.1 - 0.0049 16.8 12.0 0.0062 16.4 12.0 1.2 1 0 0 1 1 1 1 AUX/IAA family AMP-binding PF00501.28 CDI84685.1 - 0.23 10.0 6.7 0.31 9.6 6.7 1.2 1 0 0 1 1 1 0 AMP-binding enzyme VIR_N PF15912.5 CDI84685.1 - 0.8 9.2 17.7 1.2 8.7 17.7 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal FAM60A PF15396.6 CDI84685.1 - 0.97 9.4 27.8 1.1 9.2 27.8 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF4746 PF15928.5 CDI84685.1 - 1.4 8.3 21.6 2.1 7.7 21.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) NPR3 PF03666.13 CDI84685.1 - 1.9 7.2 31.8 2.5 6.8 31.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CCSAP PF15748.5 CDI84685.1 - 6 7.0 36.8 7.3 6.7 36.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Raftlin PF15250.6 CDI84685.1 - 8.3 5.0 27.1 11 4.7 27.1 1.0 1 0 0 1 1 1 0 Raftlin DUF4045 PF13254.6 CDI84685.1 - 8.6 5.9 28.1 9.7 5.7 28.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Sporozoite_P67 PF05642.11 CDI84686.1 - 4.5 5.2 7.3 4.7 5.2 7.3 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen adh_short PF00106.25 CDI84687.1 - 0.0071 15.8 0.0 0.66 9.4 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CDI84687.1 - 0.047 13.2 0.0 1.7 8.1 0.0 2.2 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase Spt20 PF12090.8 CDI84688.1 - 0.00059 19.5 9.9 0.00059 19.5 9.9 1.9 2 0 0 2 2 2 1 Spt20 family RskA PF10099.9 CDI84688.1 - 0.011 16.1 7.5 0.011 16.1 7.5 2.5 2 1 1 3 3 3 0 Anti-sigma-K factor rskA MAS20 PF02064.15 CDI84688.1 - 0.037 14.1 5.3 0.093 12.8 5.3 1.7 1 0 0 1 1 1 0 MAS20 protein import receptor DUF3381 PF11861.8 CDI84688.1 - 0.052 13.3 6.0 1.1 9.0 8.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) ThiC_Rad_SAM PF01964.18 CDI84688.1 - 0.094 11.5 3.2 0.14 10.9 3.2 1.2 1 0 0 1 1 1 0 Radical SAM ThiC family Activator_LAG-3 PF11498.8 CDI84688.1 - 3.9 6.3 25.2 0.064 12.2 17.9 1.8 2 0 0 2 2 2 0 Transcriptional activator LAG-3 TFIIA PF03153.13 CDI84688.1 - 7.8 6.4 32.6 14 5.6 32.6 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CFIA_Pcf11 PF11526.8 CDI84690.1 - 0.0058 17.1 1.0 0.0058 17.1 1.0 17.6 12 2 3 16 16 16 1 Subunit of cleavage factor IA Pcf11 GREB1 PF15782.5 CDI84691.1 - 0.017 12.3 49.7 0.021 12.0 49.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Dapper PF15268.6 CDI84691.1 - 0.48 9.2 58.1 0.55 9.0 58.1 1.0 1 0 0 1 1 1 0 Dapper Utp14 PF04615.13 CDI84691.1 - 0.91 8.0 54.4 1.1 7.7 54.4 1.0 1 0 0 1 1 1 0 Utp14 protein DUF4776 PF16003.5 CDI84691.1 - 3 6.7 51.3 4.4 6.2 51.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) SurA_N_3 PF13624.6 CDI84692.1 - 0.0098 15.7 0.8 0.0098 15.7 0.8 2.1 2 0 0 2 2 1 1 SurA N-terminal domain SurA_N_2 PF13623.6 CDI84692.1 - 0.018 14.9 3.1 0.018 14.9 3.1 2.1 2 0 0 2 2 1 0 SurA N-terminal domain PAT1 PF09770.9 CDI84692.1 - 0.026 12.8 24.2 0.026 12.8 24.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Endostatin PF06482.11 CDI84692.1 - 0.099 12.1 12.6 0.1 12.0 12.6 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin eIF-3_zeta PF05091.12 CDI84692.1 - 0.12 11.3 17.2 0.15 11.0 17.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM60A PF15396.6 CDI84692.1 - 0.5 10.3 12.5 0.61 10.0 12.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A IHABP4_N PF16174.5 CDI84692.1 - 0.62 10.7 23.2 0.84 10.2 23.2 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal DUF1387 PF07139.11 CDI84692.1 - 0.92 9.2 16.4 1.1 8.9 16.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Macoilin PF09726.9 CDI84692.1 - 1.1 7.8 14.8 1.6 7.2 14.8 1.2 1 0 0 1 1 1 0 Macoilin family RR_TM4-6 PF06459.12 CDI84692.1 - 1.2 8.9 15.4 1.7 8.4 15.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Lin-8 PF03353.15 CDI84692.1 - 1.3 8.5 20.1 1.6 8.2 20.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CCSAP PF15748.5 CDI84692.1 - 1.4 9.0 21.3 1.9 8.6 21.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated GET2 PF08690.10 CDI84692.1 - 1.8 8.2 19.6 2.2 7.9 19.6 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 CDC45 PF02724.14 CDI84692.1 - 2.2 6.5 13.9 2.5 6.3 13.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI84692.1 - 2.4 6.8 21.6 2.9 6.6 21.6 1.1 1 0 0 1 1 1 0 Presenilin Folliculin PF11704.8 CDI84692.1 - 3.6 7.4 10.5 5.3 6.9 10.5 1.4 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport LAP1C PF05609.12 CDI84692.1 - 4.6 6.2 20.9 5 6.1 20.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF4407 PF14362.6 CDI84692.1 - 8.5 5.6 19.2 12 5.2 19.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ndc1_Nup PF09531.10 CDI84692.1 - 9.1 4.8 15.6 11 4.6 15.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FYDLN_acid PF09538.10 CDI84693.1 - 3.9 8.2 16.0 4.6 8.0 16.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) PIP5K PF01504.18 CDI84694.1 - 0.0002 20.7 4.1 0.00024 20.4 4.1 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF2828 PF11443.8 CDI84694.1 - 0.0002 19.6 3.1 0.00025 19.3 3.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) Ctf8 PF09696.10 CDI84694.1 - 0.00048 20.5 10.3 0.022 15.1 3.8 2.0 2 0 0 2 2 2 2 Ctf8 SARAF PF06682.12 CDI84694.1 - 0.0005 19.8 5.1 0.00065 19.4 5.1 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis EOS1 PF12326.8 CDI84694.1 - 0.00096 19.1 3.1 0.033 14.1 0.3 2.1 2 0 0 2 2 2 1 N-glycosylation protein RskA PF10099.9 CDI84694.1 - 0.0013 19.0 13.6 0.018 15.3 0.5 2.0 1 1 1 2 2 2 1 Anti-sigma-K factor rskA Peroxin-13_N PF04088.13 CDI84694.1 - 0.0021 18.3 4.1 0.25 11.6 0.6 2.1 2 0 0 2 2 2 1 Peroxin 13, N-terminal region GWT1 PF06423.12 CDI84694.1 - 0.0022 18.2 9.6 0.0043 17.2 0.7 2.1 1 1 1 2 2 2 1 GWT1 Glyco_transf_22 PF03901.17 CDI84694.1 - 0.0025 17.1 0.8 0.036 13.3 0.7 1.9 1 1 1 2 2 2 1 Alg9-like mannosyltransferase family SID-1_RNA_chan PF13965.6 CDI84694.1 - 0.0025 16.3 5.9 0.0031 16.0 5.9 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 SLC12 PF03522.15 CDI84694.1 - 0.0032 16.6 6.0 0.0043 16.2 6.0 1.1 1 0 0 1 1 1 1 Solute carrier family 12 Gti1_Pac2 PF09729.9 CDI84694.1 - 0.0035 17.5 3.8 0.005 16.9 3.8 1.1 1 0 0 1 1 1 1 Gti1/Pac2 family Presenilin PF01080.17 CDI84694.1 - 0.0037 16.1 10.7 0.0049 15.7 10.7 1.1 1 0 0 1 1 1 1 Presenilin BatD PF13584.6 CDI84694.1 - 0.0043 15.9 5.8 0.0054 15.6 5.8 1.0 1 0 0 1 1 1 1 Oxygen tolerance DUF719 PF05334.13 CDI84694.1 - 0.0045 17.2 11.1 0.16 12.2 2.1 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF719) DUF1345 PF07077.11 CDI84694.1 - 0.0095 15.7 1.2 3.6 7.3 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) Peptidase_S49_N PF08496.10 CDI84694.1 - 0.01 15.9 7.9 0.25 11.4 1.5 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4770 PF15994.5 CDI84694.1 - 0.011 16.0 12.5 0.15 12.3 3.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) FHIPEP PF00771.20 CDI84694.1 - 0.013 14.0 0.9 0.013 14.0 0.9 2.0 1 1 1 2 2 2 0 FHIPEP family CrgA PF06781.12 CDI84694.1 - 0.014 15.4 1.4 1.1 9.4 0.1 2.2 2 0 0 2 2 2 0 Cell division protein CrgA Oxidored_q3 PF00499.20 CDI84694.1 - 0.016 15.0 0.2 0.041 13.6 0.2 1.7 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 CNDH2_N PF06278.11 CDI84694.1 - 0.02 15.1 14.9 0.21 11.8 0.3 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal DUF1892 PF08987.10 CDI84694.1 - 0.025 14.8 1.4 4.5 7.5 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1892) FGF-BP1 PF06473.12 CDI84694.1 - 0.026 14.3 21.3 0.46 10.3 8.9 2.1 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) TMEM51 PF15345.6 CDI84694.1 - 0.027 14.3 25.1 0.25 11.2 11.2 2.0 2 0 0 2 2 2 0 Transmembrane protein 51 Ripply PF14998.6 CDI84694.1 - 0.033 14.8 10.5 1 10.0 2.1 2.1 2 0 0 2 2 2 0 Transcription Regulator MAM33 PF02330.16 CDI84694.1 - 0.035 14.1 10.4 0.82 9.6 3.8 2.0 2 0 0 2 2 2 0 Mitochondrial glycoprotein Gemini_mov PF01708.16 CDI84694.1 - 0.042 13.6 6.2 0.1 12.4 6.3 1.6 1 1 0 1 1 1 0 Geminivirus putative movement protein DUF1180 PF06679.12 CDI84694.1 - 0.044 14.2 4.7 0.5 10.8 1.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Orf78 PF06024.12 CDI84694.1 - 0.045 14.0 2.8 0.045 14.0 2.8 2.2 1 1 1 2 2 2 0 Orf78 (ac78) Thg1C PF14413.6 CDI84694.1 - 0.048 13.8 10.2 0.63 10.2 3.1 2.1 2 0 0 2 2 2 0 Thg1 C terminal domain DUF2298 PF10060.9 CDI84694.1 - 0.048 12.4 0.0 0.056 12.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) GRP PF07172.11 CDI84694.1 - 0.052 14.2 2.8 1.3 9.8 1.0 2.1 2 0 0 2 2 2 0 Glycine rich protein family ExbD PF02472.16 CDI84694.1 - 0.062 13.5 9.2 0.067 13.4 9.2 1.1 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR DUF2207 PF09972.9 CDI84694.1 - 0.064 12.0 0.1 0.064 12.0 0.1 1.8 1 1 0 2 2 1 0 Predicted membrane protein (DUF2207) TFIIA PF03153.13 CDI84694.1 - 0.065 13.2 44.5 0.19 11.7 12.5 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF3671 PF12420.8 CDI84694.1 - 0.066 13.3 0.2 2.5 8.2 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF4366 PF14283.6 CDI84694.1 - 0.079 13.0 4.4 0.16 12.0 4.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) DUF819 PF05684.12 CDI84694.1 - 0.087 11.8 0.9 0.13 11.3 0.5 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF819) EcsB PF05975.12 CDI84694.1 - 0.092 11.6 5.5 0.12 11.2 5.5 1.1 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB Erv26 PF04148.13 CDI84694.1 - 0.094 12.5 2.6 0.14 11.9 2.6 1.3 1 0 0 1 1 1 0 Transmembrane adaptor Erv26 ALMT PF11744.8 CDI84694.1 - 0.098 11.5 5.1 0.15 10.9 5.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Pex14_N PF04695.13 CDI84694.1 - 0.098 13.3 26.1 0.89 10.2 12.4 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EIIBC-GUT_N PF03612.14 CDI84694.1 - 0.1 12.3 10.8 0.46 10.2 2.7 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus 7tm_1 PF00001.21 CDI84694.1 - 0.13 11.5 9.5 0.96 8.7 9.5 2.0 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) NADHdeh_related PF10125.9 CDI84694.1 - 0.15 11.4 0.2 0.5 9.7 0.0 1.7 1 1 1 2 2 2 0 NADH dehydrogenase I, subunit N related protein RBM39linker PF15519.6 CDI84694.1 - 0.15 13.1 13.7 2.1 9.5 6.0 2.1 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein Apc15p PF05841.11 CDI84694.1 - 0.16 12.8 19.4 0.16 12.8 6.5 2.1 2 0 0 2 2 2 0 Apc15p protein DUF3367 PF11847.8 CDI84694.1 - 0.16 9.8 2.0 2.4 5.9 0.0 2.0 1 1 1 2 2 2 0 Alpha-(1->3)-arabinofuranosyltransferase DUF4519 PF15012.6 CDI84694.1 - 0.17 12.0 0.1 0.17 12.0 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Mak10 PF04112.13 CDI84694.1 - 0.18 11.3 7.7 0.65 9.5 1.5 2.1 2 0 0 2 2 2 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase EphA2_TM PF14575.6 CDI84694.1 - 0.18 12.7 19.0 1.3 9.9 4.1 2.4 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain PigN PF04987.14 CDI84694.1 - 0.19 10.6 17.7 0.1 11.4 7.5 2.1 1 1 1 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) PIG-U PF06728.13 CDI84694.1 - 0.19 10.7 10.5 0.029 13.4 2.6 2.0 1 1 1 2 2 2 0 GPI transamidase subunit PIG-U Gaa1 PF04114.14 CDI84694.1 - 0.22 10.5 11.7 0.064 12.3 2.6 2.0 1 1 1 2 2 2 0 Gaa1-like, GPI transamidase component XRN1_D2_D3 PF18334.1 CDI84694.1 - 0.23 11.7 4.4 7.1 6.9 0.6 2.2 2 0 0 2 2 2 0 Exoribonuclease Xrn1 D2/D3 domain Topoisom_I_N PF02919.15 CDI84694.1 - 0.24 10.9 6.1 4.3 6.8 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment RcpC PF16976.5 CDI84694.1 - 0.24 11.5 13.7 0.68 10.0 5.0 2.1 2 0 0 2 2 2 0 Flp pilus assembly protein RcpC/CpaB Tau95_N PF17682.1 CDI84694.1 - 0.24 11.6 8.3 0.49 10.6 1.4 2.1 2 0 0 2 2 2 0 Tau95 Triple barrel domain MFS_1_like PF12832.7 CDI84694.1 - 0.25 10.1 5.1 2.4 6.9 5.1 1.9 1 1 0 1 1 1 0 MFS_1 like family Pilin_N PF07790.11 CDI84694.1 - 0.26 12.2 1.2 1.4 9.9 0.0 2.1 2 0 0 2 2 1 0 Archaeal Type IV pilin, N-terminal Mss4 PF04421.13 CDI84694.1 - 0.28 11.4 5.8 2.8 8.1 1.1 2.2 2 0 0 2 2 2 0 Mss4 protein TUSC2 PF15000.6 CDI84694.1 - 0.3 11.4 5.8 4.4 7.6 1.5 2.1 2 0 0 2 2 2 0 Tumour suppressor candidate 2 DUF3853 PF12964.7 CDI84694.1 - 0.32 11.2 7.2 3.4 7.9 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3853) DUF4064 PF13273.6 CDI84694.1 - 0.34 11.2 12.6 0.16 12.3 2.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) CIAPIN1 PF05093.13 CDI84694.1 - 0.35 11.4 10.5 1.2 9.7 1.0 2.2 2 0 0 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis MDM10 PF12519.8 CDI84694.1 - 0.4 9.5 7.4 0.57 9.0 7.4 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 MITF_TFEB_C_3_N PF15951.5 CDI84694.1 - 0.4 11.3 43.4 0.73 10.4 19.6 2.1 2 0 0 2 2 2 0 MITF/TFEB/TFEC/TFE3 N-terminus RPA43_OB PF17875.1 CDI84694.1 - 0.41 11.3 7.8 2.4 8.8 1.7 2.1 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I FAM176 PF14851.6 CDI84694.1 - 0.42 10.3 13.7 0.23 11.1 1.0 2.1 1 1 1 2 2 2 0 FAM176 family Pet20 PF08692.10 CDI84694.1 - 0.49 11.1 5.1 8.4 7.1 1.4 2.1 2 0 0 2 2 2 0 Mitochondrial protein Pet20 Cas1_AcylT PF07779.12 CDI84694.1 - 0.5 9.2 12.6 0.43 9.4 2.9 2.1 1 1 1 2 2 2 0 10 TM Acyl Transferase domain found in Cas1p DUF3899 PF13038.6 CDI84694.1 - 0.53 10.8 2.9 1.3 9.6 0.1 2.4 1 1 2 3 3 2 0 Domain of unknown function (DUF3899) DUF4710 PF15828.5 CDI84694.1 - 0.54 10.4 5.6 4.2 7.5 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Ipi1_N PF12333.8 CDI84694.1 - 0.57 10.8 7.9 12 6.5 4.4 2.1 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation MAGE PF01454.19 CDI84694.1 - 0.58 9.8 10.3 2.1 8.0 0.3 2.1 2 0 0 2 2 2 0 MAGE family DUF3506 PF12014.8 CDI84694.1 - 0.61 10.1 8.8 3.3 7.7 3.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3506) SRP9-21 PF05486.12 CDI84694.1 - 0.61 10.5 7.6 9.2 6.7 0.1 2.1 2 0 0 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) Rad54_N PF08658.10 CDI84694.1 - 0.72 10.0 7.5 3.9 7.6 2.0 2.1 2 0 0 2 2 2 0 Rad54 N terminal DUF2722 PF10846.8 CDI84694.1 - 0.76 8.6 50.8 0.3 10.0 15.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) WASH-7_C PF14746.6 CDI84694.1 - 0.83 9.3 15.9 0.15 11.7 3.1 2.1 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal Calpain_inhib PF00748.19 CDI84694.1 - 0.83 10.2 8.2 6.2 7.3 3.9 2.1 2 0 0 2 2 2 0 Calpain inhibitor TMEM223 PF14640.6 CDI84694.1 - 0.88 9.7 9.1 0.42 10.8 1.3 2.1 1 1 1 2 2 2 0 Transmembrane protein 223 ANAPC_CDC26 PF10471.9 CDI84694.1 - 0.89 10.4 48.6 4.4 8.2 23.3 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 DUF2973 PF11189.8 CDI84694.1 - 0.95 9.6 7.9 3 8.0 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) OPA3 PF07047.12 CDI84694.1 - 0.99 9.2 11.5 3.4 7.4 0.2 2.1 2 0 0 2 2 2 0 Optic atrophy 3 protein (OPA3) DUF979 PF06166.12 CDI84694.1 - 1 8.5 7.2 0.68 9.0 1.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF979) DivIC PF04977.15 CDI84694.1 - 1.1 9.0 36.2 0.33 10.7 7.0 2.2 2 0 0 2 2 2 0 Septum formation initiator Rsc14 PF08586.10 CDI84694.1 - 1.1 10.1 11.3 5.8 7.8 0.8 2.1 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit CagX PF03524.15 CDI84694.1 - 1.2 8.8 10.1 2.5 7.8 2.6 2.0 2 0 0 2 2 2 0 Conjugal transfer protein ULD PF16534.5 CDI84694.1 - 1.2 9.2 8.0 1.9 8.6 1.4 2.3 2 0 0 2 2 2 0 Ubiquitin-like oligomerisation domain of SATB DUF2371 PF10177.9 CDI84694.1 - 1.3 9.2 6.7 2.6 8.2 6.7 1.5 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DUF4079 PF13301.6 CDI84694.1 - 1.4 9.1 8.4 2.4 8.3 1.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) 2HCT PF03390.15 CDI84694.1 - 1.5 7.4 6.1 1.1 7.8 2.0 1.8 1 1 1 2 2 2 0 2-hydroxycarboxylate transporter family Med15 PF09606.10 CDI84694.1 - 1.6 7.3 49.4 0.89 8.2 23.1 2.0 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal MPM1 PF17234.2 CDI84694.1 - 1.7 8.9 20.5 2.7 8.2 8.0 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 PepSY_TM_like_2 PF16357.5 CDI84694.1 - 1.9 8.4 4.5 2.7 7.9 4.5 1.2 1 0 0 1 1 1 0 Putative PepSY_TM-like DUF3357 PF11837.8 CDI84694.1 - 2 8.9 7.0 8.3 6.9 2.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) DUF3381 PF11861.8 CDI84694.1 - 2.1 8.1 19.1 1.9 8.3 6.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) TOM13 PF08219.11 CDI84694.1 - 2.3 8.3 6.4 14 5.7 1.1 2.1 2 0 0 2 2 2 0 Outer membrane protein TOM13 Cytochrom_B_N_2 PF13631.6 CDI84694.1 - 2.8 7.9 4.7 3.1 7.8 0.6 2.0 1 1 1 2 2 2 0 Cytochrome b(N-terminal)/b6/petB ATAD4 PF15321.6 CDI84694.1 - 3.5 9.0 10.8 8.6 7.8 3.1 2.1 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 DUF5385 PF17359.2 CDI84694.1 - 3.5 7.1 13.7 5.7 6.4 1.5 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5385) Rpp20 PF12328.8 CDI84694.1 - 3.6 7.5 18.3 5.7 6.9 2.4 2.0 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P DUF5327 PF17261.2 CDI84694.1 - 3.7 8.4 29.1 3.7 8.4 11.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5327) MH2 PF03166.14 CDI84694.1 - 3.8 7.7 19.5 0.49 10.6 5.6 2.1 2 0 0 2 2 2 0 MH2 domain DUF3499 PF12005.8 CDI84694.1 - 3.9 8.1 10.6 23 5.6 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3499) HD-ZIP_N PF04618.12 CDI84694.1 - 4.7 7.8 8.8 3.6 8.1 0.8 2.1 2 0 0 2 2 2 0 HD-ZIP protein N terminus Trp_oprn_chp PF09534.10 CDI84694.1 - 4.8 6.9 6.6 1.6e+02 1.9 8.4 1.9 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) tRNA_lig_CPD PF08302.11 CDI84694.1 - 5.1 6.5 15.2 5.3 6.4 2.3 2.1 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain RNA_pol_Rbc25 PF08292.12 CDI84694.1 - 5.1 7.3 14.8 5.9 7.1 1.1 2.1 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 eIF-3_zeta PF05091.12 CDI84694.1 - 5.1 6.0 22.4 0.65 8.9 1.9 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2269 PF10027.9 CDI84694.1 - 5.4 7.1 7.4 6.3 6.8 0.3 2.0 1 1 1 2 2 2 0 Predicted integral membrane protein (DUF2269) NapE PF06796.11 CDI84694.1 - 5.4 6.6 6.3 12 5.6 1.9 2.9 2 1 0 2 2 2 0 Periplasmic nitrate reductase protein NapE DUF3169 PF11368.8 CDI84694.1 - 5.4 6.4 8.9 0.34 10.4 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) DUF4050 PF13259.6 CDI84694.1 - 5.5 7.3 13.2 8.3 6.7 13.2 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF4050) CLN3 PF02487.17 CDI84694.1 - 6 5.8 16.7 51 2.7 16.8 1.8 1 1 0 1 1 1 0 CLN3 protein DUF4736 PF15883.5 CDI84694.1 - 6.3 6.5 19.5 2.6 7.7 6.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) RuvC_III PF18541.1 CDI84694.1 - 6.4 6.7 12.7 3.8 7.4 3.4 2.0 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 DUF2227 PF09988.9 CDI84694.1 - 7.3 6.4 13.8 2 8.3 0.9 2.0 1 1 1 2 2 2 0 Uncharacterized metal-binding protein (DUF2227) BK_channel_a PF03493.18 CDI84694.1 - 7.4 6.8 9.1 2.9 8.1 0.7 2.2 1 1 1 2 2 2 0 Calcium-activated BK potassium channel alpha subunit DUF92 PF01940.16 CDI84694.1 - 7.6 5.9 5.1 0.68 9.3 0.3 1.6 1 1 1 2 2 1 0 Integral membrane protein DUF92 RRN9 PF10680.9 CDI84694.1 - 7.7 6.9 10.1 9.6 6.6 0.8 2.1 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor UPF0560 PF10577.9 CDI84694.1 - 8 4.8 27.7 2.3 6.6 11.6 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 Na_H_antiport_3 PF07399.11 CDI84694.1 - 9.1 5.0 6.5 11 4.7 5.7 1.4 1 1 1 2 2 2 0 Putative Na+/H+ antiporter TMEM154 PF15102.6 CDI84694.1 - 9.5 6.1 7.0 68 3.4 6.0 2.1 1 1 0 1 1 1 0 TMEM154 protein family CBP_BcsG PF11658.8 CDI84694.1 - 9.5 4.5 17.4 1.9 6.8 1.6 2.0 1 1 1 2 2 2 0 Cellulose biosynthesis protein BcsG PH_4 PF15404.6 CDI84694.1 - 9.9 5.9 12.3 11 5.8 0.5 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain TMEM51 PF15345.6 CDI84695.1 - 0.0091 15.9 5.0 0.0091 15.9 5.0 2.1 1 1 1 2 2 2 1 Transmembrane protein 51 RskA PF10099.9 CDI84695.1 - 0.026 14.8 11.8 9.7 6.4 0.0 2.1 1 1 0 2 2 2 0 Anti-sigma-K factor rskA Herpes_glycop PF01528.16 CDI84695.1 - 0.66 8.8 2.5 1.2 7.9 2.5 1.4 1 0 0 1 1 1 0 Herpesvirus glycoprotein M Hamartin PF04388.12 CDI84695.1 - 3.5 6.2 25.7 3.9 6.0 25.7 1.1 1 0 0 1 1 1 0 Hamartin protein TMEM215 PF15746.5 CDI84695.1 - 4.1 6.8 11.7 7.7 5.9 11.7 1.5 1 0 0 1 1 1 0 TMEM215 family DUF2681 PF10883.8 CDI84695.1 - 4.6 7.7 17.8 0.69 10.4 2.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) PPP4R2 PF09184.11 CDI84695.1 - 5.4 6.5 25.2 6.5 6.2 25.2 1.1 1 0 0 1 1 1 0 PPP4R2 Utp14 PF04615.13 CDI84695.1 - 9.4 4.7 24.1 13 4.2 24.1 1.2 1 0 0 1 1 1 0 Utp14 protein SPX PF03105.19 CDI84696.1 - 0.00098 19.1 35.8 0.093 12.6 17.2 2.2 2 0 0 2 2 2 2 SPX domain TCP PF03634.13 CDI84696.1 - 0.0069 17.0 8.4 0.0069 17.0 8.4 4.4 4 0 0 4 4 4 2 TCP family transcription factor CDC45 PF02724.14 CDI84696.1 - 0.61 8.3 28.4 0.023 13.0 10.7 3.1 3 0 0 3 3 3 0 CDC45-like protein SpoIIP PF07454.11 CDI84696.1 - 1 8.8 30.3 0.24 10.8 19.3 3.3 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) MRP-S31 PF15433.6 CDI84696.1 - 2.3 7.8 27.0 0.083 12.5 12.1 3.2 3 0 0 3 3 3 0 Mitochondrial 28S ribosomal protein S31 Utp14 PF04615.13 CDI84696.1 - 5.8 5.4 33.5 3.1 6.3 18.2 2.2 2 0 0 2 2 2 0 Utp14 protein EOS1 PF12326.8 CDI84696.1 - 9 6.2 21.5 6.5 6.7 8.2 3.7 4 0 0 4 4 4 0 N-glycosylation protein Spt20 PF12090.8 CDI84697.1 - 0.00028 20.6 14.2 0.00028 20.6 14.2 11.1 7 2 2 9 9 9 2 Spt20 family Androgen_recep PF02166.16 CDI84697.1 - 0.00028 19.9 5.5 0.00028 19.9 5.5 16.2 8 5 3 14 14 14 1 Androgen receptor Oxidored_q2 PF00420.24 CDI84697.1 - 0.12 12.0 0.6 11 5.7 0.1 2.7 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Med15 PF09606.10 CDI84698.1 - 0.041 12.6 46.7 0.053 12.2 46.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Connexin PF00029.19 CDI84698.1 - 4.8 6.9 10.6 2.7 7.7 4.4 2.4 2 0 0 2 2 2 0 Connexin V_ATPase_I PF01496.19 CDI84699.1 - 0.0037 15.3 1.0 0.0044 15.0 1.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF1180 PF06679.12 CDI84699.1 - 0.025 15.0 2.3 0.033 14.6 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) OATP PF03137.20 CDI84699.1 - 0.027 12.8 0.1 0.029 12.7 0.1 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CLN3 PF02487.17 CDI84699.1 - 0.076 12.0 0.1 0.09 11.8 0.1 1.0 1 0 0 1 1 1 0 CLN3 protein DUF2076 PF09849.9 CDI84699.1 - 0.077 13.0 16.4 0.087 12.9 16.4 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) RIC3 PF15361.6 CDI84699.1 - 0.086 13.2 4.0 0.12 12.8 4.0 1.1 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Tmemb_9 PF05434.11 CDI84699.1 - 0.13 12.2 2.4 0.21 11.5 2.4 1.3 1 1 0 1 1 1 0 TMEM9 TFIIA PF03153.13 CDI84699.1 - 0.57 10.1 17.5 0.8 9.6 17.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Conotoxin PF02950.17 CDI84699.1 - 0.58 11.2 3.9 1.9 9.6 0.2 2.1 2 0 0 2 2 2 0 Conotoxin TMEM208_SND2 PF05620.11 CDI84699.1 - 0.71 9.6 2.2 18 5.1 1.0 2.1 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 DUF2973 PF11189.8 CDI84699.1 - 1.4 9.1 4.8 0.74 9.9 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) MITF_TFEB_C_3_N PF15951.5 CDI84699.1 - 2.3 8.8 21.1 6.1 7.5 4.8 2.1 2 0 0 2 2 2 0 MITF/TFEB/TFEC/TFE3 N-terminus Siah-Interact_N PF09032.11 CDI84699.1 - 2.8 8.3 10.9 1.4 9.3 2.0 2.1 2 0 0 2 2 2 0 Siah interacting protein, N terminal T2SSC PF11356.8 CDI84699.1 - 3.4 7.6 5.9 1.6 8.6 3.1 1.6 1 1 0 1 1 1 0 Type II secretion system protein C EphA2_TM PF14575.6 CDI84699.1 - 3.9 8.4 5.1 17 6.4 5.1 1.8 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Jiraiya PF15038.6 CDI84699.1 - 6 6.3 5.9 0.37 10.2 0.9 1.4 2 0 0 2 2 2 0 Jiraiya PulG PF11773.8 CDI84699.1 - 9.3 6.2 8.1 17 5.3 1.1 2.1 2 0 0 2 2 2 0 Type II secretory pathway pseudopilin RskA PF10099.9 CDI84703.1 - 0.00011 22.5 12.3 0.00011 22.5 12.3 7.4 2 2 4 6 6 6 2 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI84707.1 - 6.3e-05 23.2 34.0 0.022 14.8 15.0 2.4 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Tau95_N PF17682.1 CDI84707.1 - 0.024 14.8 2.1 0.33 11.1 0.3 2.5 2 0 0 2 2 2 0 Tau95 Triple barrel domain AP2 PF00847.20 CDI84707.1 - 0.41 10.9 0.0 0.41 10.9 0.0 3.9 4 0 0 4 4 4 0 AP2 domain TERB2 PF15101.6 CDI84707.1 - 0.91 9.5 16.3 0.53 10.3 2.0 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Spt20 PF12090.8 CDI84707.1 - 1.1 8.8 55.2 2.7 7.5 20.7 2.2 2 0 0 2 2 2 0 Spt20 family Neur_chan_memb PF02932.16 CDI84707.1 - 1.5 8.8 6.4 7.2 6.6 0.5 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PAT1 PF09770.9 CDI84707.1 - 3.3 5.9 26.4 0.58 8.4 9.0 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 AIF_C PF14721.6 CDI84707.1 - 4.8 7.5 7.5 9.8 6.6 0.1 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term ANAPC_CDC26 PF10471.9 CDI84707.1 - 6.2 7.7 40.8 13 6.7 14.6 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 EPL1 PF10513.9 CDI84707.1 - 6.5 7.1 13.6 5 7.5 1.1 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like Ribosomal_60s PF00428.19 CDI84708.1 - 0.021 15.4 32.0 0.021 15.4 32.0 10.6 1 1 7 8 8 8 0 60s Acidic ribosomal protein RskA PF10099.9 CDI84708.1 - 0.5 10.6 20.2 0.44 10.8 9.6 2.5 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF2497 PF10691.9 CDI84709.1 - 1.1 9.7 0.0 1.1 9.7 0.0 4.0 6 0 0 6 6 6 0 Protein of unknown function (DUF2497) DAGK_acc PF00609.19 CDI84710.1 - 2.3e-27 96.3 0.0 3.6e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 CDI84710.1 - 1.8e-17 63.1 0.0 5.5e-17 61.6 0.0 1.8 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Pkinase_Tyr PF07714.17 CDI84711.1 - 3.9e-50 170.5 0.0 2.4e-29 102.4 0.0 3.4 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.25 CDI84711.1 - 3.1e-47 161.2 0.0 2.6e-45 154.8 0.0 3.0 2 1 0 2 2 2 1 Protein kinase domain MORN PF02493.20 CDI84711.1 - 6.6e-07 28.9 20.0 0.00051 19.8 1.5 4.2 4 0 0 4 4 4 2 MORN repeat SAM_1 PF00536.30 CDI84711.1 - 0.00051 20.4 0.4 0.0011 19.4 0.4 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CDI84711.1 - 0.028 14.5 0.2 0.058 13.5 0.2 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF4149 PF13664.6 CDI84712.1 - 4.8e-07 30.1 3.0 2.4e-06 27.8 0.6 3.1 3 1 0 3 3 3 1 Domain of unknown function (DUF4149) E7 PF00527.18 CDI84713.1 - 2.7 8.2 7.0 15 5.8 4.0 2.9 2 1 0 2 2 2 0 E7 protein, Early protein Kelch_4 PF13418.6 CDI84714.1 - 2.1e-19 69.3 1.2 0.00013 21.9 0.0 4.7 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_3 PF13415.6 CDI84714.1 - 4.3e-19 68.3 3.8 1.4e-05 25.3 0.1 5.3 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI84714.1 - 1.4e-10 40.9 1.0 0.00069 19.5 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 CDI84714.1 - 1e-09 38.3 0.7 0.063 13.6 0.0 5.2 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 CDI84714.1 - 4.3e-05 23.0 0.8 2.1 8.0 0.2 4.3 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 CDI84714.1 - 0.0091 15.9 5.2 24 5.1 1.7 4.7 6 1 0 6 6 6 0 Kelch motif ECM11 PF15463.6 CDI84714.1 - 0.013 16.1 2.2 0.026 15.1 2.2 1.4 1 0 0 1 1 1 0 Extracellular mutant protein 11 GldM_N PF12081.8 CDI84714.1 - 0.05 13.7 0.4 0.05 13.7 0.4 1.6 2 0 0 2 2 2 0 GldM N-terminal domain PV-1 PF06637.11 CDI84714.1 - 0.091 11.6 2.7 0.13 11.1 2.7 1.1 1 0 0 1 1 1 0 PV-1 protein (PLVAP) RAG2 PF03089.14 CDI84714.1 - 0.11 11.5 0.0 1.1 8.2 0.0 2.4 2 1 1 3 3 3 0 Recombination activating protein 2 Spectrin PF00435.21 CDI84714.1 - 0.57 10.7 4.7 5.6 7.5 0.1 2.3 1 1 1 2 2 2 0 Spectrin repeat Ribosomal_L6e PF01159.19 CDI84715.1 - 7.4e-36 123.1 1.8 1.1e-35 122.5 1.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L6e Ycf54 PF10674.9 CDI84715.1 - 0.1 12.9 0.3 0.21 11.9 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2488) Acetyltransf_1 PF00583.25 CDI84718.1 - 2.1e-15 57.0 0.0 2.5e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDI84718.1 - 3e-11 43.4 0.0 4.2e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDI84718.1 - 3.5e-11 43.4 0.0 4.5e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CDI84718.1 - 7.2e-06 26.7 0.0 8.3e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDI84718.1 - 6.4e-05 23.0 0.1 0.00018 21.6 0.0 1.7 1 1 1 2 2 2 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 CDI84718.1 - 0.00076 19.4 0.0 0.0014 18.6 0.0 1.4 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CDI84718.1 - 0.05 13.7 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CDI84718.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 CDI84718.1 - 0.16 11.5 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase AMP-binding PF00501.28 CDI84719.1 - 0.00012 20.9 0.2 0.23 10.0 0.5 2.6 2 0 0 2 2 2 2 AMP-binding enzyme Pkinase PF00069.25 CDI84720.1 - 1.1e-35 123.3 0.0 9.4e-15 54.7 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI84720.1 - 5.3e-10 39.0 0.1 0.00013 21.3 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase DUF4834 PF16118.5 CDI84721.1 - 2.5e-07 31.6 10.7 1.6e-05 25.7 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) SUIM_assoc PF16619.5 CDI84721.1 - 3.9e-05 23.6 0.0 3.9e-05 23.6 0.0 4.3 2 2 2 4 4 2 1 Unstructured region C-term to UIM in Ataxin3 V_ATPase_I PF01496.19 CDI84721.1 - 0.003 15.6 3.1 0.003 15.6 3.1 2.1 1 1 1 2 2 2 1 V-type ATPase 116kDa subunit family CBP_BcsG PF11658.8 CDI84721.1 - 0.0047 15.4 3.1 0.0047 15.4 3.1 2.0 1 1 1 2 2 2 1 Cellulose biosynthesis protein BcsG PRA1 PF03208.19 CDI84721.1 - 0.011 15.4 4.3 0.019 14.6 3.9 1.6 2 0 0 2 2 2 0 PRA1 family protein PalH PF08733.10 CDI84721.1 - 0.011 14.7 0.1 0.027 13.5 0.0 1.7 1 1 0 1 1 1 0 PalH/RIM21 SARAF PF06682.12 CDI84721.1 - 0.014 15.1 18.5 0.08 12.6 18.5 2.1 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Pex24p PF06398.11 CDI84721.1 - 0.014 14.4 6.3 0.011 14.8 4.7 1.7 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin Wzy_C PF04932.15 CDI84721.1 - 0.016 14.9 0.2 0.038 13.6 0.1 1.9 1 1 0 1 1 1 0 O-Antigen ligase RskA PF10099.9 CDI84721.1 - 0.019 15.2 0.3 0.019 15.2 0.3 3.2 1 1 2 3 3 2 0 Anti-sigma-K factor rskA FA_desaturase PF00487.24 CDI84721.1 - 0.027 14.3 9.5 0.025 14.4 3.7 2.8 2 1 1 3 3 3 0 Fatty acid desaturase BAF1_ABF1 PF04684.13 CDI84721.1 - 0.071 12.2 15.1 0.1 11.7 15.1 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Pex14_N PF04695.13 CDI84721.1 - 0.13 12.9 38.5 0.059 14.0 19.5 2.2 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4446 PF14584.6 CDI84721.1 - 0.22 11.5 7.1 0.36 10.8 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) G0-G1_switch_2 PF15103.6 CDI84721.1 - 0.36 11.3 10.4 4.3 7.8 4.3 2.4 2 0 0 2 2 2 0 G0/G1 switch protein 2 SID-1_RNA_chan PF13965.6 CDI84721.1 - 0.42 9.0 7.7 9.2 4.5 7.7 2.0 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 ABC_trans_N PF14510.6 CDI84721.1 - 0.43 11.2 5.7 0.92 10.2 0.2 2.1 2 0 0 2 2 2 0 ABC-transporter N-terminal DUF812 PF05667.11 CDI84721.1 - 0.77 8.6 23.0 0.99 8.2 23.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF5427 PF10310.9 CDI84721.1 - 0.86 8.5 25.2 1.1 8.2 25.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SLC12 PF03522.15 CDI84721.1 - 1.1 8.1 12.9 1.5 7.7 12.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Shadoo PF14999.6 CDI84721.1 - 1.2 9.2 12.8 0.089 12.9 1.3 2.2 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective ADP_ribosyl_GH PF03747.14 CDI84721.1 - 1.5 8.5 15.7 1.4 8.6 14.9 1.3 1 1 0 1 1 1 0 ADP-ribosylglycohydrolase DUF2722 PF10846.8 CDI84721.1 - 2.6 6.9 37.5 3 6.7 10.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) CitMHS PF03600.16 CDI84721.1 - 4.8 6.3 10.8 17 4.5 10.3 1.9 1 1 0 1 1 1 0 Citrate transporter Miff PF05644.11 CDI84721.1 - 6.2 6.4 18.1 7.9 6.0 18.1 1.1 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Neur_chan_memb PF02932.16 CDI84721.1 - 6.7 6.7 21.2 16 5.5 21.2 1.7 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Comm PF15957.5 CDI84721.1 - 7 7.0 10.5 98 3.3 10.3 2.5 1 1 0 1 1 1 0 Commissureless DUF4603 PF15376.6 CDI84723.1 - 0.078 10.4 33.2 0.1 10.0 33.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Caldesmon PF02029.15 CDI84723.1 - 0.51 9.0 65.1 0.83 8.3 65.1 1.3 1 0 0 1 1 1 0 Caldesmon DUF4551 PF15087.6 CDI84723.1 - 0.86 8.4 47.1 1.1 8.0 47.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CobT PF06213.12 CDI84723.1 - 1.9 7.8 85.5 0.12 11.7 35.0 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT LAP1C PF05609.12 CDI84723.1 - 7.5 5.5 64.1 9.2 5.2 64.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Otopetrin PF03189.13 CDI84724.1 - 0.028 13.3 2.8 0.038 12.8 2.8 1.3 1 0 0 1 1 1 0 Otopetrin Sporozoite_P67 PF05642.11 CDI84724.1 - 0.2 9.7 8.2 0.2 9.7 8.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4148 PF13663.6 CDI84724.1 - 0.87 9.8 18.1 2.2 8.5 2.7 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) DUF913 PF06025.12 CDI84724.1 - 2.2 7.1 11.1 3.3 6.6 11.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Apt1 PF10351.9 CDI84724.1 - 2.7 6.8 15.0 3.4 6.4 15.0 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_S64 PF08192.11 CDI84724.1 - 3 6.2 15.0 3.2 6.1 15.0 1.2 1 0 0 1 1 1 0 Peptidase family S64 Membralin PF09746.9 CDI84724.1 - 3.5 6.6 10.2 4.4 6.2 10.2 1.2 1 0 0 1 1 1 0 Tumour-associated protein SOBP PF15279.6 CDI84724.1 - 3.5 8.1 21.1 5.2 7.6 21.1 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein PAT1 PF09770.9 CDI84724.1 - 5.1 5.2 34.6 5.6 5.1 34.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2370 PF10176.9 CDI84724.1 - 5.8 6.5 7.9 10 5.7 7.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Band_3_cyto PF07565.13 CDI84724.1 - 6.8 6.4 21.1 12 5.6 21.1 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF724 PF05266.14 CDI84724.1 - 7.5 6.3 20.4 15 5.3 20.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) CDC45 PF02724.14 CDI84724.1 - 9.6 4.4 19.1 14 3.8 19.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Shadoo PF14999.6 CDI84726.1 - 1.8 8.7 17.0 4.9 7.3 17.0 1.7 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective UPF0564 PF10595.9 CDI84727.1 - 0.00067 18.8 10.2 0.00067 18.8 10.2 2.1 2 0 0 2 2 2 1 Uncharacterised protein family UPF0564 SUIM_assoc PF16619.5 CDI84727.1 - 0.019 15.0 9.5 0.019 15.0 9.5 6.1 4 2 1 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 CNDH2_C PF16858.5 CDI84727.1 - 0.95 9.3 25.7 0.92 9.3 7.5 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Lin-8 PF03353.15 CDI84727.1 - 3.1 7.3 36.1 4.5 6.8 12.9 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist AAA_23 PF13476.6 CDI84727.1 - 5 7.6 31.8 0.068 13.7 5.0 2.2 2 0 0 2 2 2 0 AAA domain Nop53 PF07767.11 CDI84727.1 - 6.1 6.1 49.0 0.44 9.9 19.4 2.1 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) DUF5585 PF17823.1 CDI84727.1 - 6.4 5.6 40.3 8.8 5.2 40.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Utp14 PF04615.13 CDI84727.1 - 7.5 5.0 41.4 10 4.6 41.4 1.0 1 0 0 1 1 1 0 Utp14 protein DUF5308 PF17233.2 CDI84729.1 - 0.2 11.9 8.6 0.22 11.7 8.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Afi1 PF07792.12 CDI84729.1 - 0.27 11.7 12.8 0.32 11.5 12.8 1.0 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4746 PF15928.5 CDI84729.1 - 0.66 9.3 10.3 0.67 9.3 10.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF702 PF05142.12 CDI84729.1 - 0.74 10.3 11.1 1.1 9.7 11.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) CSRNP_N PF16019.5 CDI84729.1 - 0.88 9.4 15.6 0.87 9.5 15.6 1.0 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Band_3_cyto PF07565.13 CDI84729.1 - 1.3 8.7 14.0 1.4 8.7 14.0 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Mit_KHE1 PF10173.9 CDI84729.1 - 1.5 8.8 10.5 1.9 8.5 10.5 1.1 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Pex14_N PF04695.13 CDI84729.1 - 1.8 9.2 18.0 2.1 9.0 18.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PPL5 PF18168.1 CDI84729.1 - 1.9 7.7 11.0 2 7.6 11.0 1.0 1 0 0 1 1 1 0 Prim-pol family 5 TFIIA PF03153.13 CDI84729.1 - 1.9 8.4 34.0 2.3 8.2 34.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 CDI84729.1 - 2.6 5.8 16.7 2.9 5.7 16.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 CDI84729.1 - 2.6 7.7 10.5 2.5 7.8 10.5 1.1 1 0 0 1 1 1 0 Connexin Gti1_Pac2 PF09729.9 CDI84729.1 - 3.1 7.8 10.7 3.4 7.7 10.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Endonuc_Holl PF10107.9 CDI84729.1 - 3.5 7.4 13.3 3.9 7.3 13.3 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase EPL1 PF10513.9 CDI84729.1 - 4.2 7.7 15.1 5.5 7.4 15.1 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like FAM60A PF15396.6 CDI84729.1 - 4.8 7.1 10.8 5.4 7.0 10.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SpoIIP PF07454.11 CDI84729.1 - 5.6 6.3 15.8 5.7 6.3 15.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) EIIBC-GUT_N PF03612.14 CDI84729.1 - 6 6.6 11.4 7.4 6.3 11.4 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 CDI84729.1 - 6.3 5.4 17.2 6.7 5.4 17.2 1.0 1 0 0 1 1 1 0 Presenilin Membralin PF09746.9 CDI84729.1 - 7.1 5.6 11.5 7.3 5.5 11.5 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF4446 PF14584.6 CDI84729.1 - 7.4 6.6 10.4 8.3 6.4 10.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Hydin_ADK PF17213.3 CDI84729.1 - 9 6.5 12.0 12 6.1 12.0 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain MMR1 PF08505.10 CDI84729.1 - 9.1 6.5 18.9 11 6.3 18.9 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Kei1 PF08552.11 CDI84729.1 - 9.1 6.1 8.6 9.6 6.0 8.6 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 HCO3_cotransp PF00955.21 CDI84729.1 - 9.4 4.9 11.9 11 4.8 11.9 1.0 1 0 0 1 1 1 0 HCO3- transporter family Neur_chan_memb PF02932.16 CDI84729.1 - 9.6 6.2 12.1 10 6.1 12.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RskA PF10099.9 CDI84730.1 - 0.0092 16.3 23.3 0.0092 16.3 23.3 10.4 3 3 5 8 8 8 2 Anti-sigma-K factor rskA Pex14_N PF04695.13 CDI84730.1 - 0.019 15.6 15.2 0.019 15.6 15.2 9.7 4 3 1 5 5 5 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PI3K_C2 PF00792.24 CDI84730.1 - 0.048 13.6 0.0 0.048 13.6 0.0 4.7 6 0 0 6 6 6 0 Phosphoinositide 3-kinase C2 NAM-associated PF14303.6 CDI84730.1 - 0.55 10.9 0.0 0.55 10.9 0.0 7.5 5 3 1 7 7 7 0 No apical meristem-associated C-terminal domain SAPS PF04499.15 CDI84731.1 - 0.079 11.7 21.7 0.097 11.4 21.7 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SLC12 PF03522.15 CDI84731.1 - 0.35 9.8 32.4 0.38 9.7 32.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 CDI84731.1 - 0.36 9.5 39.5 0.39 9.4 39.5 1.0 1 0 0 1 1 1 0 Presenilin PNISR PF15996.5 CDI84731.1 - 0.58 10.4 33.4 0.72 10.1 33.4 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR GREB1 PF15782.5 CDI84731.1 - 1.3 6.0 31.2 1.5 5.9 31.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ALMT PF11744.8 CDI84731.1 - 2.3 6.9 27.1 2.5 6.8 27.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter AAA_11 PF13086.6 CDI84731.1 - 3.6 7.3 29.6 3.8 7.2 29.6 1.1 1 0 0 1 1 1 0 AAA domain MCM_bind PF09739.9 CDI84731.1 - 6.3 5.1 29.0 7.2 4.9 29.0 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Apt1 PF10351.9 CDI84731.1 - 6.4 5.5 22.9 7.2 5.3 22.9 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Dsh_C PF12316.8 CDI84731.1 - 6.9 7.0 21.2 8.5 6.7 21.2 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF4045 PF13254.6 CDI84731.1 - 7.3 6.1 29.5 7.9 6.0 29.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CCDC53 PF10152.9 CDI84733.1 - 0.0036 17.7 12.4 0.005 17.3 12.4 1.2 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex Serinc PF03348.15 CDI84733.1 - 0.014 14.3 5.1 0.015 14.2 5.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF3807 PF12720.7 CDI84733.1 - 0.034 14.4 18.8 0.044 14.0 18.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) RR_TM4-6 PF06459.12 CDI84733.1 - 0.037 13.9 13.4 0.045 13.6 13.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 V_ATPase_I PF01496.19 CDI84733.1 - 0.053 11.4 16.5 0.058 11.3 16.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-3_zeta PF05091.12 CDI84733.1 - 0.063 12.3 19.5 0.082 11.9 19.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TMEM144 PF07857.12 CDI84733.1 - 0.075 12.0 0.8 0.076 12.0 0.8 1.1 1 0 0 1 1 1 0 Transmembrane family, TMEM144 of transporters DUF572 PF04502.13 CDI84733.1 - 0.093 12.3 15.0 0.11 12.1 15.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) FAM60A PF15396.6 CDI84733.1 - 0.11 12.5 10.5 0.13 12.2 10.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Neuraminidase PF18413.1 CDI84733.1 - 0.12 12.0 9.9 0.15 11.7 9.9 1.1 1 0 0 1 1 1 0 Neuraminidase-like domain Neur_chan_memb PF02932.16 CDI84733.1 - 0.14 12.2 13.2 0.16 12.0 13.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Kei1 PF08552.11 CDI84733.1 - 0.14 12.0 10.3 0.26 11.2 10.3 1.5 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF2207 PF09972.9 CDI84733.1 - 0.21 10.3 0.5 0.23 10.2 0.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SLC12 PF03522.15 CDI84733.1 - 0.32 10.0 17.1 0.35 9.8 17.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SID-1_RNA_chan PF13965.6 CDI84733.1 - 0.32 9.3 5.1 0.37 9.1 5.1 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Endostatin PF06482.11 CDI84733.1 - 0.42 10.0 17.7 0.48 9.8 17.7 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF2126 PF09899.9 CDI84733.1 - 0.46 8.5 9.7 0.54 8.3 9.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Smg8_Smg9 PF10220.9 CDI84733.1 - 0.47 8.7 17.7 0.54 8.5 17.7 1.0 1 0 0 1 1 1 0 Smg8_Smg9 DDHD PF02862.17 CDI84733.1 - 0.48 10.5 15.9 0.63 10.2 15.9 1.1 1 0 0 1 1 1 0 DDHD domain DUF4045 PF13254.6 CDI84733.1 - 0.5 9.9 13.0 0.64 9.6 13.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CSG2 PF16965.5 CDI84733.1 - 0.6 9.0 7.9 0.75 8.7 7.9 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator DUF3357 PF11837.8 CDI84733.1 - 0.6 10.6 5.5 1.4 9.4 5.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) DUF4050 PF13259.6 CDI84733.1 - 0.61 10.4 15.1 0.84 9.9 15.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Presenilin PF01080.17 CDI84733.1 - 0.63 8.7 22.0 0.8 8.4 22.0 1.1 1 0 0 1 1 1 0 Presenilin Velvet PF11754.8 CDI84733.1 - 0.77 9.6 17.5 0.92 9.4 17.5 1.1 1 0 0 1 1 1 0 Velvet factor FAM91_C PF14648.6 CDI84733.1 - 1.1 8.0 14.3 1.3 7.8 14.3 1.0 1 0 0 1 1 1 0 FAM91 C-terminus Zip PF02535.22 CDI84733.1 - 1.3 8.2 8.8 1.8 7.7 8.8 1.3 1 1 0 1 1 1 0 ZIP Zinc transporter TRAP_alpha PF03896.16 CDI84733.1 - 1.3 8.1 10.4 0.17 11.1 5.7 1.7 1 1 1 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Het-C PF07217.11 CDI84733.1 - 1.3 7.4 14.4 1.4 7.4 14.4 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Saw1 PF11561.8 CDI84733.1 - 1.4 8.4 14.7 1.8 8.0 14.7 1.2 1 0 0 1 1 1 0 Single strand annealing-weakened 1 ALMT PF11744.8 CDI84733.1 - 1.8 7.3 15.6 2.2 7.0 15.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter RICTOR_N PF14664.6 CDI84733.1 - 2 7.3 12.2 0.68 8.9 9.7 1.4 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term HCO3_cotransp PF00955.21 CDI84733.1 - 2 7.1 6.4 2.3 6.9 6.4 1.2 1 0 0 1 1 1 0 HCO3- transporter family TMEM154 PF15102.6 CDI84733.1 - 2.4 8.0 7.2 0.39 10.6 1.7 2.2 1 1 2 3 3 3 0 TMEM154 protein family CCSAP PF15748.5 CDI84733.1 - 2.6 8.2 22.1 3.3 7.8 22.1 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated 2OG-FeII_Oxy_5 PF13759.6 CDI84733.1 - 2.6 8.5 8.3 0.89 10.0 5.2 1.7 2 0 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase Sec62 PF03839.16 CDI84733.1 - 2.8 7.4 13.7 4 6.9 13.7 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Senescence_reg PF04520.13 CDI84733.1 - 3.1 8.6 14.5 3.9 8.3 14.5 1.0 1 0 0 1 1 1 0 Senescence regulator DUF2464 PF10240.9 CDI84733.1 - 3.6 7.1 12.9 4.4 6.8 12.9 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 DUF740 PF05340.12 CDI84733.1 - 4.1 6.0 9.4 4.8 5.8 9.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF740) MAJIN PF15077.6 CDI84733.1 - 5.3 6.8 11.3 7.1 6.3 11.3 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein MDM10 PF12519.8 CDI84733.1 - 5.4 5.8 13.1 7.2 5.4 13.1 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF1180 PF06679.12 CDI84733.1 - 5.9 7.3 16.8 7.2 7.0 9.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1180) GET2 PF08690.10 CDI84733.1 - 6 6.4 24.5 7.9 6.0 24.5 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 DUF4471 PF14740.6 CDI84733.1 - 6.2 5.9 13.1 7.9 5.6 13.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) PNGaseA PF12222.8 CDI84733.1 - 6.4 5.5 14.2 7.4 5.3 14.2 1.0 1 0 0 1 1 1 0 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A DcuA_DcuB PF03605.14 CDI84733.1 - 6.7 5.5 6.9 3.5 6.4 5.4 1.3 1 1 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter AUX_IAA PF02309.16 CDI84733.1 - 6.9 6.5 12.1 8.2 6.2 12.1 1.1 1 0 0 1 1 1 0 AUX/IAA family PAT1 PF09770.9 CDI84733.1 - 7.1 4.8 37.0 8.6 4.5 37.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Orf78 PF06024.12 CDI84733.1 - 7.9 6.8 16.0 4.3e+02 1.3 16.0 2.2 1 1 0 1 1 1 0 Orf78 (ac78) XRN_M PF17846.1 CDI84733.1 - 8.2 5.3 13.2 10 4.9 13.2 1.1 1 0 0 1 1 1 0 Xrn1 helical domain O-antigen_lig PF13425.6 CDI84733.1 - 9.4 4.9 7.5 12 4.6 7.5 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Spt20 PF12090.8 CDI84734.1 - 0.49 10.0 73.3 0.031 13.9 13.6 3.1 3 0 0 3 3 3 0 Spt20 family Spt20 PF12090.8 CDI84735.1 - 0.0038 16.9 6.6 0.0043 16.7 6.6 1.1 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI84735.1 - 0.0051 15.8 3.7 0.0061 15.6 3.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TYW3 PF02676.14 CDI84735.1 - 0.013 14.9 1.8 0.016 14.6 1.8 1.2 1 0 0 1 1 1 0 Methyltransferase TYW3 Sec62 PF03839.16 CDI84735.1 - 0.39 10.2 3.6 0.36 10.3 3.6 1.2 1 1 0 1 1 1 0 Translocation protein Sec62 TFIIA PF03153.13 CDI84735.1 - 0.61 10.0 12.9 0.76 9.7 12.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI84735.1 - 0.88 8.2 18.8 1.1 7.9 18.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal NACHT_N PF17100.5 CDI84735.1 - 1.2 8.9 8.6 1.4 8.7 8.6 1.1 1 0 0 1 1 1 0 N-terminal domain of NWD NACHT-NTPase BAT2_N PF07001.11 CDI84735.1 - 8 6.9 14.9 10 6.5 14.9 1.1 1 0 0 1 1 1 0 BAT2 N-terminus eIF-3_zeta PF05091.12 CDI84736.1 - 0.13 11.3 13.7 0.19 10.7 13.7 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Connexin PF00029.19 CDI84736.1 - 1.5 8.5 6.1 2.2 8.0 6.1 1.4 1 0 0 1 1 1 0 Connexin SpoIIP PF07454.11 CDI84736.1 - 1.5 8.2 11.0 2.8 7.3 11.0 1.5 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) HrpB7 PF09486.10 CDI84737.1 - 0.00067 20.1 13.2 0.00067 20.1 13.2 1.7 2 0 0 2 2 2 1 Bacterial type III secretion protein (HrpB7) Spt20 PF12090.8 CDI84737.1 - 0.0028 17.3 12.3 0.0032 17.1 12.3 1.1 1 0 0 1 1 1 1 Spt20 family DUF3535 PF12054.8 CDI84737.1 - 0.0029 16.9 2.4 0.0037 16.6 2.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3535) DUF775 PF05603.12 CDI84737.1 - 0.0053 16.3 0.6 0.0053 16.3 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF775) DUF853 PF05872.12 CDI84737.1 - 0.0075 14.9 3.0 0.0085 14.7 3.0 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF853) DUF4570 PF15134.6 CDI84737.1 - 0.011 15.7 7.6 0.019 15.0 7.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) Pex14_N PF04695.13 CDI84737.1 - 0.016 15.9 7.0 0.021 15.5 7.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Goodbye PF17109.5 CDI84737.1 - 0.022 15.2 3.8 0.022 15.2 3.8 1.5 2 0 0 2 2 1 0 fungal STAND N-terminal Goodbye domain TFIIA PF03153.13 CDI84737.1 - 0.051 13.6 13.5 0.061 13.3 13.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4199 PF13858.6 CDI84737.1 - 0.068 13.6 0.7 0.1 13.0 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) PRKG1_interact PF15898.5 CDI84737.1 - 0.14 13.1 7.6 0.2 12.6 7.6 1.2 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF2722 PF10846.8 CDI84737.1 - 0.19 10.7 12.5 0.22 10.4 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Cdh1_DBD_1 PF18196.1 CDI84737.1 - 0.28 11.5 4.1 0.47 10.8 4.1 1.3 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Nitroreductase PF00881.24 CDI84737.1 - 0.55 10.3 10.0 0.76 9.8 10.0 1.2 1 0 0 1 1 1 0 Nitroreductase family Dfp1_Him1_M PF08630.10 CDI84737.1 - 0.63 10.3 4.5 0.99 9.6 4.5 1.2 1 0 0 1 1 1 0 Dfp1/Him1, central region eIF3_subunit PF08597.10 CDI84737.1 - 0.65 9.9 6.9 0.82 9.5 6.9 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF4690 PF15756.5 CDI84737.1 - 1.2 9.8 7.6 87 3.8 7.6 2.3 1 1 0 1 1 1 0 Small Novel Rich in Cartilage Roughex PF06020.11 CDI84737.1 - 1.8 7.6 6.6 2.1 7.4 6.6 1.1 1 0 0 1 1 1 0 Drosophila roughex protein RskA PF10099.9 CDI84737.1 - 2.9 8.2 31.1 0.019 15.3 13.0 2.1 1 1 1 2 2 1 0 Anti-sigma-K factor rskA FTZ PF03867.14 CDI84737.1 - 3 7.3 7.3 3.8 7.0 7.3 1.3 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region DUF4736 PF15883.5 CDI84737.1 - 6.9 6.3 11.7 11 5.7 11.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4736) DUF5349 PF17298.2 CDI84737.1 - 6.9 6.3 10.4 9.2 5.9 10.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5349) RBM39linker PF15519.6 CDI84737.1 - 8.9 7.5 10.0 1.3 10.1 6.2 1.5 2 0 0 2 2 1 0 linker between RRM2 and RRM3 domains in RBM39 protein MecA PF05389.12 CDI84738.1 - 0.00066 19.4 3.5 0.00096 18.9 3.5 1.1 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) DUF3357 PF11837.8 CDI84738.1 - 0.012 16.1 0.5 0.012 16.1 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) Neur_chan_memb PF02932.16 CDI84738.1 - 0.087 12.9 1.0 0.092 12.8 1.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region G0-G1_switch_2 PF15103.6 CDI84738.1 - 0.11 12.9 5.2 0.19 12.2 5.2 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 EOS1 PF12326.8 CDI84738.1 - 0.15 12.0 0.1 0.15 12.0 0.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein EIIBC-GUT_N PF03612.14 CDI84738.1 - 0.31 10.8 6.6 0.46 10.2 6.6 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CPSF100_C PF13299.6 CDI84738.1 - 0.31 11.2 8.6 0.59 10.3 8.6 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal PEX11 PF05648.14 CDI84738.1 - 0.33 10.4 9.5 0.48 9.8 9.5 1.1 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Ipi1_N PF12333.8 CDI84738.1 - 0.45 11.1 6.0 0.81 10.3 6.0 1.4 1 0 0 1 1 1 0 Rix1 complex component involved in 60S ribosome maturation DUF4834 PF16118.5 CDI84738.1 - 0.64 11.0 13.0 1.1 10.3 13.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Pex14_N PF04695.13 CDI84738.1 - 0.68 10.6 26.7 2.2 8.9 20.7 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Peptidase_S15 PF02129.18 CDI84738.1 - 0.76 9.3 13.4 0.023 14.3 6.9 1.6 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Presenilin PF01080.17 CDI84738.1 - 0.9 8.2 9.6 1.2 7.8 9.6 1.1 1 0 0 1 1 1 0 Presenilin FYDLN_acid PF09538.10 CDI84738.1 - 0.95 10.2 5.6 5.8 7.6 2.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DDHD PF02862.17 CDI84738.1 - 0.96 9.6 9.0 1.4 9.0 9.0 1.2 1 0 0 1 1 1 0 DDHD domain DUF775 PF05603.12 CDI84738.1 - 1.2 8.6 12.6 2 7.9 12.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Spt20 PF12090.8 CDI84738.1 - 1.4 8.5 37.7 2.2 7.8 37.7 1.4 1 0 0 1 1 1 0 Spt20 family Connexin PF00029.19 CDI84738.1 - 1.4 8.6 5.9 1.9 8.2 5.9 1.1 1 0 0 1 1 1 0 Connexin DUF3464 PF11947.8 CDI84738.1 - 1.4 8.6 7.8 2.4 7.9 7.8 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DIE2_ALG10 PF04922.12 CDI84738.1 - 1.6 7.9 5.0 2.2 7.5 5.0 1.1 1 0 0 1 1 1 0 DIE2/ALG10 family eIF-3_zeta PF05091.12 CDI84738.1 - 1.9 7.4 16.3 2.3 7.1 16.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Orf78 PF06024.12 CDI84738.1 - 2.6 8.4 5.4 4 7.8 5.4 1.3 1 0 0 1 1 1 0 Orf78 (ac78) RICTOR_N PF14664.6 CDI84738.1 - 3 6.7 7.4 4 6.3 7.4 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term CSG2 PF16965.5 CDI84738.1 - 3.1 6.6 4.8 3.6 6.5 4.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator TFIIA PF03153.13 CDI84738.1 - 4 7.3 36.4 0.67 9.9 31.9 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit EphA2_TM PF14575.6 CDI84738.1 - 5 8.1 5.0 9.8 7.1 5.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain YABBY PF04690.13 CDI84738.1 - 7.5 7.1 9.2 10 6.7 9.2 1.2 1 0 0 1 1 1 0 YABBY protein Suf PF05843.14 CDI84738.1 - 8.4 6.3 17.4 14 5.6 17.4 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Sec62 PF03839.16 CDI84738.1 - 8.9 5.7 10.1 11 5.4 10.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 SUIM_assoc PF16619.5 CDI84739.1 - 0.0012 18.9 4.4 0.0012 18.9 4.4 4.5 4 2 0 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 cwf18 PF08315.12 CDI84739.1 - 0.0054 17.4 0.2 0.0054 17.4 0.2 2.8 2 1 0 3 3 3 1 cwf18 pre-mRNA splicing factor DUF1682 PF07946.14 CDI84739.1 - 0.34 10.1 5.5 0.55 9.4 5.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Hamartin PF04388.12 CDI84739.1 - 0.41 9.3 17.7 0.5 9.0 17.7 1.1 1 0 0 1 1 1 0 Hamartin protein Fer4_18 PF13746.6 CDI84739.1 - 0.75 10.0 4.2 4.5 7.5 0.1 2.6 3 0 0 3 3 3 0 4Fe-4S dicluster domain DAG_kinase_N PF14513.6 CDI84741.1 - 0.066 13.4 18.3 0.083 13.1 18.3 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Vac7 PF12751.7 CDI84741.1 - 0.07 12.6 17.9 0.035 13.6 16.4 1.2 1 1 0 1 1 1 0 Vacuolar segregation subunit 7 DUF572 PF04502.13 CDI84741.1 - 2.7 7.5 18.3 3.1 7.3 18.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) P16-Arc PF04699.14 CDI84741.1 - 5.6 7.5 25.3 3 8.3 7.3 2.1 2 0 0 2 2 2 0 ARP2/3 complex 16 kDa subunit (p16-Arc) PAT1 PF09770.9 CDI84743.1 - 0.086 11.1 34.0 0.11 10.8 34.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Activator_LAG-3 PF11498.8 CDI84743.1 - 0.39 9.6 62.0 0.83 8.6 62.0 1.5 1 0 0 1 1 1 0 Transcriptional activator LAG-3 AF-4 PF05110.13 CDI84743.1 - 2.1 6.3 67.7 0.0079 14.4 41.3 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein MtrE PF04206.12 CDI84743.1 - 4 6.7 5.3 8.8 5.6 5.3 1.5 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit E Sporozoite_P67 PF05642.11 CDI84744.1 - 5.4e-05 21.5 5.1 6.5e-05 21.2 5.1 1.0 1 0 0 1 1 1 1 Sporozoite P67 surface antigen DUF1645 PF07816.11 CDI84744.1 - 0.00061 20.4 4.7 0.00061 20.4 4.7 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1645) Spt20 PF12090.8 CDI84744.1 - 0.00068 19.3 16.2 0.0014 18.3 13.8 1.9 2 0 0 2 2 2 1 Spt20 family TFIIA PF03153.13 CDI84744.1 - 0.0055 16.7 18.2 0.0075 16.3 18.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI84744.1 - 0.006 15.6 12.7 0.006 15.6 12.7 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI84744.1 - 0.015 15.6 12.2 0.015 15.6 12.2 2.6 1 1 1 2 2 1 0 Anti-sigma-K factor rskA BBS2_N PF14781.6 CDI84744.1 - 0.03 14.2 0.1 0.1 12.5 0.1 1.9 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, N-terminal PIG-U PF06728.13 CDI84744.1 - 0.053 12.6 0.4 0.058 12.4 0.4 1.1 1 0 0 1 1 1 0 GPI transamidase subunit PIG-U DRY_EERY PF09750.9 CDI84744.1 - 0.076 13.3 0.8 0.076 13.3 0.8 1.8 2 0 0 2 2 2 0 Alternative splicing regulator GREB1 PF15782.5 CDI84744.1 - 0.44 7.6 9.2 0.54 7.3 9.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 CDI84744.1 - 0.48 8.9 13.5 0.043 12.4 2.6 2.1 2 0 0 2 2 2 0 Macoilin family Activator_LAG-3 PF11498.8 CDI84744.1 - 0.76 8.7 19.4 1.6 7.7 19.4 1.5 1 0 0 1 1 1 0 Transcriptional activator LAG-3 EIIBC-GUT_N PF03612.14 CDI84744.1 - 1 9.1 3.9 6.6 6.4 0.3 2.3 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Lin-8 PF03353.15 CDI84744.1 - 1.3 8.5 14.1 0.27 10.8 9.5 1.8 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Trp_oprn_chp PF09534.10 CDI84744.1 - 2.6 7.8 38.4 5.6 6.7 38.4 1.5 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) BAF1_ABF1 PF04684.13 CDI84744.1 - 2.7 6.9 14.3 0.45 9.5 0.6 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor LCD1 PF09798.9 CDI84744.1 - 3.1 6.2 8.5 5.2 5.5 6.4 1.9 2 0 0 2 2 2 0 DNA damage checkpoint protein MPM1 PF17234.2 CDI84744.1 - 3.3 8.0 10.6 0.66 10.2 5.3 1.9 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Suf PF05843.14 CDI84744.1 - 3.4 7.6 8.6 5.1 7.0 8.6 1.5 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) AF-4 PF05110.13 CDI84744.1 - 4.4 5.3 19.7 0.84 7.6 15.8 1.6 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Nop14 PF04147.12 CDI84745.1 - 0.41 8.8 40.9 0.43 8.7 40.9 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 CDI84745.1 - 2.4 6.3 35.6 2.6 6.2 35.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Mpp10 PF04006.12 CDI84745.1 - 3.3 6.0 42.6 3.6 5.9 42.6 1.0 1 0 0 1 1 1 0 Mpp10 protein DNA_pol_phi PF04931.13 CDI84745.1 - 4.6 5.2 43.9 5.1 5.1 43.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop53 PF07767.11 CDI84745.1 - 6.7 6.0 40.4 7.3 5.9 40.4 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF3292 PF11696.8 CDI84745.1 - 6.8 4.9 12.1 7.8 4.7 12.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Afi1 PF07792.12 CDI84745.1 - 8.7 6.8 22.5 12 6.4 22.5 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking BORG_CEP PF14957.6 CDI84745.1 - 9.4 7.4 11.9 11 7.2 11.9 1.1 1 0 0 1 1 1 0 Cdc42 effector CSRNP_N PF16019.5 CDI84745.1 - 10 6.0 16.1 11 5.9 16.1 1.0 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF945 PF06097.11 CDI84746.1 - 0.02 14.0 13.8 0.023 13.8 13.8 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) CD20 PF04103.15 CDI84746.1 - 0.08 13.0 0.3 0.11 12.6 0.3 1.3 1 0 0 1 1 1 0 CD20-like family Activator_LAG-3 PF11498.8 CDI84746.1 - 0.47 9.4 35.7 0.51 9.2 35.7 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.13 CDI84746.1 - 0.52 10.3 26.6 0.63 10.0 26.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI84746.1 - 3 8.1 23.6 14 5.9 23.6 1.8 1 1 0 1 1 1 0 Anti-sigma-K factor rskA TALPID3 PF15324.6 CDI84746.1 - 7.2 4.1 20.4 7.9 4.0 20.4 1.0 1 0 0 1 1 1 0 Hedgehog signalling target AF-4 PF05110.13 CDI84748.1 - 0.00012 20.3 18.4 0.00014 20.2 18.4 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein RskA PF10099.9 CDI84748.1 - 0.00059 20.2 4.8 0.00069 20.0 4.8 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF3146 PF11344.8 CDI84748.1 - 0.014 15.0 0.3 0.028 14.1 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3146) TALPID3 PF15324.6 CDI84748.1 - 0.025 12.3 8.9 0.03 12.0 8.9 1.0 1 0 0 1 1 1 0 Hedgehog signalling target DUF4207 PF13904.6 CDI84748.1 - 0.043 13.5 15.2 0.019 14.7 13.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4207) DUF45 PF01863.17 CDI84748.1 - 0.049 13.7 1.3 0.064 13.3 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF45 His_Phos_1 PF00300.22 CDI84748.1 - 0.079 12.6 2.5 0.093 12.4 2.5 1.1 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) ICA69 PF04629.14 CDI84748.1 - 1.2 9.4 14.8 1.4 9.1 14.8 1.1 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain Suf PF05843.14 CDI84748.1 - 2.4 8.1 11.3 3 7.8 11.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FAM199X PF15814.5 CDI84748.1 - 7.6 5.5 14.2 8.9 5.3 14.2 1.1 1 0 0 1 1 1 0 Protein family FAM199X SMYLE_N PF18615.1 CDI84748.1 - 7.8 6.0 11.9 8.5 5.8 11.9 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Presenilin PF01080.17 CDI84748.1 - 8.8 5.0 11.2 10 4.8 11.2 1.1 1 0 0 1 1 1 0 Presenilin Helicase_C PF00271.31 CDI84750.1 - 8.5e-34 116.2 0.1 2e-33 115.1 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDI84750.1 - 9.3e-11 41.8 0.8 1.7e-10 40.9 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase UTP25 PF06862.12 CDI84750.1 - 0.0045 15.8 0.0 0.0099 14.7 0.0 1.6 1 1 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF2722 PF10846.8 CDI84750.1 - 0.013 14.4 6.9 0.02 13.9 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI84750.1 - 1.3 8.6 17.9 2 8.0 17.9 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI84750.1 - 1.8 8.5 12.9 2.6 7.9 12.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 CDI84750.1 - 4.1 6.4 6.4 6 5.9 6.4 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Activator_LAG-3 PF11498.8 CDI84750.1 - 5.1 6.0 19.5 7.4 5.4 19.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF572 PF04502.13 CDI84751.1 - 0.00011 22.0 47.1 0.00017 21.3 47.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF572) Utp14 PF04615.13 CDI84751.1 - 0.15 10.6 46.4 0.19 10.3 46.4 1.0 1 0 0 1 1 1 0 Utp14 protein FHIPEP PF00771.20 CDI84751.1 - 0.24 9.8 4.2 0.44 9.0 4.2 1.4 1 0 0 1 1 1 0 FHIPEP family OmpH PF03938.14 CDI84751.1 - 5.5 7.3 47.5 0.035 14.4 10.7 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Lin-8 PF03353.15 CDI84752.1 - 9e-06 25.5 18.2 9e-06 25.5 18.2 1.1 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist LMBR1 PF04791.16 CDI84752.1 - 2.5e-05 23.4 12.1 2.8e-05 23.3 12.1 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein Peptidase_S64 PF08192.11 CDI84752.1 - 0.0001 21.0 11.1 0.0001 21.0 11.1 1.2 1 0 0 1 1 1 1 Peptidase family S64 Apt1 PF10351.9 CDI84752.1 - 0.00016 20.7 6.2 0.00016 20.7 6.2 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain RR_TM4-6 PF06459.12 CDI84752.1 - 0.00029 20.7 20.5 0.00029 20.7 20.5 1.6 2 0 0 2 2 2 1 Ryanodine Receptor TM 4-6 SID-1_RNA_chan PF13965.6 CDI84752.1 - 0.00054 18.5 7.0 0.00062 18.3 7.0 1.3 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Hid1 PF12722.7 CDI84752.1 - 0.00064 18.0 16.3 0.00065 18.0 16.3 1.1 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein DUF2151 PF10221.9 CDI84752.1 - 0.0014 17.3 4.9 0.0014 17.3 4.9 1.1 1 0 0 1 1 1 1 Cell cycle and development regulator SOG2 PF10428.9 CDI84752.1 - 0.0016 17.7 19.9 0.0019 17.5 19.9 1.1 1 0 0 1 1 1 1 RAM signalling pathway protein Shisa PF13908.6 CDI84752.1 - 0.0032 17.7 16.0 0.0032 17.7 16.0 2.1 1 1 1 2 2 1 1 Wnt and FGF inhibitory regulator CSG2 PF16965.5 CDI84752.1 - 0.011 14.7 13.4 0.023 13.6 13.2 1.7 1 1 0 1 1 1 0 Ceramide synthase regulator Pkinase_fungal PF17667.1 CDI84752.1 - 0.013 14.3 6.8 0.012 14.4 6.8 1.2 1 0 0 1 1 1 0 Fungal protein kinase CDC45 PF02724.14 CDI84752.1 - 0.025 12.9 24.7 0.034 12.5 24.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2828 PF11443.8 CDI84752.1 - 0.16 10.0 27.1 0.22 9.6 27.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DAG_kinase_N PF14513.6 CDI84752.1 - 0.23 11.6 26.4 0.032 14.4 21.6 1.8 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus DUF2781 PF10914.8 CDI84752.1 - 0.24 11.8 11.3 0.085 13.3 8.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2781) 5_nucleotid PF05761.14 CDI84752.1 - 1 8.2 20.2 1.2 8.0 20.2 1.1 1 0 0 1 1 1 0 5' nucleotidase family Plasmodium_Vir PF05795.11 CDI84752.1 - 1.2 8.5 15.3 1.8 7.9 15.3 1.5 1 1 0 1 1 1 0 Plasmodium vivax Vir protein Caldesmon PF02029.15 CDI84752.1 - 1.5 7.5 29.1 1.9 7.2 29.1 1.1 1 0 0 1 1 1 0 Caldesmon DUF443 PF04276.12 CDI84752.1 - 1.9 8.2 3.3 0.73 9.6 0.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF443) LAP1C PF05609.12 CDI84752.1 - 2.2 7.3 33.4 0.011 14.8 24.7 1.5 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) CDK5_activator PF03261.15 CDI84752.1 - 3.9 6.9 22.7 5.8 6.3 22.7 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein ALMT PF11744.8 CDI84752.1 - 3.9 6.2 24.8 5.8 5.6 24.8 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM60A PF15396.6 CDI84752.1 - 4.2 7.3 26.0 7 6.6 26.0 1.4 1 0 0 1 1 1 0 Protein Family FAM60A DUF2370 PF10176.9 CDI84752.1 - 4.5 6.9 15.9 0.18 11.4 10.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) DUF2126 PF09899.9 CDI84752.1 - 7 4.6 20.4 12 3.9 20.4 1.4 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Peroxin-3 PF04882.12 CDI84752.1 - 8.8 5.2 30.7 0.061 12.3 21.8 1.8 2 0 0 2 2 2 0 Peroxin-3 Mgr1 PF08602.10 CDI84752.1 - 9.1 5.0 13.4 17 4.1 13.4 1.6 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit HCO3_cotransp PF00955.21 CDI84752.1 - 9.4 4.9 19.8 3.4 6.4 17.3 1.4 1 1 0 1 1 1 0 HCO3- transporter family CCDC53 PF10152.9 CDI84754.1 - 1.3 9.4 6.5 1.8 9.0 6.5 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF4407 PF14362.6 CDI84754.1 - 3.9 6.8 12.4 4.5 6.5 12.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FSA_C PF10479.9 CDI84754.1 - 4.9 5.2 7.8 5 5.1 7.8 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Ndc1_Nup PF09531.10 CDI84754.1 - 5.7 5.5 6.2 6.4 5.3 6.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SR-25 PF10500.9 CDI84755.1 - 0.0054 16.4 20.4 0.0054 16.4 20.4 4.1 2 1 2 4 4 4 3 Nuclear RNA-splicing-associated protein Utp14 PF04615.13 CDI84755.1 - 2.5 6.5 55.9 0.061 11.9 49.7 1.3 2 0 0 2 2 2 0 Utp14 protein Hamartin PF04388.12 CDI84755.1 - 3.1 6.3 68.1 5.5 5.5 68.1 1.3 1 0 0 1 1 1 0 Hamartin protein TFIIA PF03153.13 CDI84756.1 - 3.8 7.4 13.2 7.9 6.4 13.2 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI84757.1 - 1.3 7.2 24.0 1.3 7.2 24.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ELFV_dehydrog PF00208.21 CDI84758.1 - 3.8e-81 272.4 0.5 4.8e-81 272.1 0.5 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 CDI84758.1 - 2.6e-50 169.7 0.0 7e-50 168.3 0.0 1.8 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.6 CDI84758.1 - 0.00018 21.9 0.1 0.00062 20.2 0.0 1.9 2 0 0 2 2 2 1 Putative NAD(P)-binding ThiF PF00899.21 CDI84758.1 - 0.04 13.3 0.2 0.095 12.0 0.0 1.6 2 0 0 2 2 2 0 ThiF family 2-Hacid_dh_C PF02826.19 CDI84758.1 - 0.077 12.3 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Bac_GDH PF05088.12 CDI84758.1 - 0.081 10.4 0.0 0.11 10.0 0.0 1.1 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase Trypan_PARP PF05887.11 CDI84759.1 - 3.8 7.5 23.5 1.5 8.8 9.7 2.9 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) IMUP PF15761.5 CDI84760.1 - 0.011 16.4 11.6 0.071 13.8 11.6 2.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF2076 PF09849.9 CDI84761.1 - 0.0022 18.1 11.7 0.0022 18.1 11.7 3.6 2 1 1 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2076) Adeno_PIX PF03955.14 CDI84761.1 - 2.1 8.6 14.1 1.9 8.7 3.5 2.6 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) Pinin_SDK_memA PF04696.13 CDI84762.1 - 0.37 10.9 55.4 0.1 12.7 25.6 2.1 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Prothymosin PF03247.14 CDI84762.1 - 1.2 9.6 28.4 1.9 9.0 10.9 2.4 2 0 0 2 2 2 0 Prothymosin/parathymosin family Herpes_pp85 PF04637.12 CDI84762.1 - 1.8 6.9 12.5 2.7 6.3 12.5 1.4 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Peptidase_S64 PF08192.11 CDI84762.1 - 4.1 5.8 52.1 4.6 5.6 52.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 SR-25 PF10500.9 CDI84762.1 - 4.5 6.8 63.1 56 3.2 63.1 2.2 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DDRGK PF09756.9 CDI84762.1 - 9.7 5.7 50.0 2.3 7.8 22.5 2.1 2 0 0 2 2 2 0 DDRGK domain Sec66 PF09802.9 CDI84763.1 - 1.8e-08 34.2 15.4 1.8e-08 34.2 15.4 3.0 2 1 1 3 3 3 1 Preprotein translocase subunit Sec66 SpoIIIAH PF12685.7 CDI84763.1 - 0.0021 18.0 1.9 0.0021 18.0 1.9 2.6 2 1 0 2 2 2 1 SpoIIIAH-like protein Macoilin PF09726.9 CDI84763.1 - 4.8 5.6 50.1 6.8 5.1 50.1 1.1 1 0 0 1 1 1 0 Macoilin family FAM60A PF15396.6 CDI84763.1 - 6.8 6.6 36.5 6.2 6.8 2.2 2.7 2 0 0 2 2 2 0 Protein Family FAM60A Lin-8 PF03353.15 CDI84763.1 - 7.1 6.1 51.5 6.3 6.3 35.0 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist CCDC24 PF15669.5 CDI84764.1 - 0.2 11.5 0.0 0.2 11.5 0.0 6.7 3 2 1 4 4 4 0 Coiled-coil domain-containing protein 24 family Carb_anhydrase PF00194.21 CDI84766.1 - 1.1e-13 51.3 11.3 3e-08 33.5 0.0 3.9 3 1 1 4 4 4 2 Eukaryotic-type carbonic anhydrase RskA PF10099.9 CDI84766.1 - 6.9e-07 29.7 0.0 6.9e-07 29.7 0.0 5.3 2 1 3 5 5 5 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI84766.1 - 1.2e-05 25.0 9.3 1.2e-05 25.0 9.3 3.5 3 0 0 3 3 3 2 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 CDI84766.1 - 0.0056 14.9 56.5 0.097 10.8 38.2 2.4 2 1 0 2 2 2 2 AF-4 proto-oncoprotein DUF2722 PF10846.8 CDI84766.1 - 0.008 15.2 19.8 0.008 15.2 19.8 5.2 2 1 3 5 5 5 1 Protein of unknown function (DUF2722) EIF4E-T PF10477.9 CDI84766.1 - 2.6 6.8 51.8 0.74 8.6 27.1 2.1 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Caldesmon PF02029.15 CDI84766.1 - 3.7 6.2 39.3 0.032 13.0 6.0 2.3 2 0 0 2 2 2 0 Caldesmon Neur_chan_memb PF02932.16 CDI84766.1 - 7.8 6.5 45.8 0.98 9.4 20.1 2.8 2 1 1 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region CSRNP_N PF16019.5 CDI84767.1 - 1.2 9.0 29.8 3.3 7.6 14.8 2.3 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus RNF111_N PF15303.6 CDI84767.1 - 1.3 8.7 30.0 0.85 9.3 5.3 2.2 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase Arkadia N-terminus eIF-3_zeta PF05091.12 CDI84767.1 - 7.3 5.4 37.8 0.31 10.0 12.2 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RskA PF10099.9 CDI84767.1 - 8.1 6.7 56.2 55 4.0 36.8 3.4 1 1 1 2 2 2 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI84768.1 - 3.4e-07 30.8 35.6 0.00094 19.5 22.3 2.3 2 0 0 2 2 2 2 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI84768.1 - 9.6e-05 22.6 54.0 0.0032 17.6 24.2 2.0 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit SAGA-Tad1 PF12767.7 CDI84768.1 - 0.0036 17.1 4.0 0.0036 17.1 4.0 2.1 2 0 0 2 2 2 2 Transcriptional regulator of RNA polII, SAGA, subunit Suf PF05843.14 CDI84768.1 - 0.02 14.9 20.9 0.065 13.2 6.1 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) EOS1 PF12326.8 CDI84768.1 - 0.039 13.9 4.0 0.64 9.9 0.7 2.2 2 0 0 2 2 2 0 N-glycosylation protein rRNA_processing PF08524.11 CDI84768.1 - 0.3 11.1 24.7 0.37 10.8 5.5 3.2 3 0 0 3 3 3 0 rRNA processing TBCC_N PF16752.5 CDI84768.1 - 0.51 10.8 23.3 3.9 8.0 2.6 3.3 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain FHIPEP PF00771.20 CDI84768.1 - 1.9 6.9 6.6 2.3 6.6 1.8 2.2 2 0 0 2 2 2 0 FHIPEP family NEMP PF10225.9 CDI84768.1 - 4 7.0 5.4 2.8 7.5 1.3 2.2 2 0 0 2 2 2 0 NEMP family Macoilin PF09726.9 CDI84769.1 - 0.00033 19.4 3.8 0.00033 19.4 3.8 4.7 3 1 0 3 3 3 2 Macoilin family RskA PF10099.9 CDI84769.1 - 0.002 18.4 0.0 0.002 18.4 0.0 13.7 2 2 7 10 10 10 3 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI84769.1 - 0.0069 16.0 6.7 0.0069 16.0 6.7 9.6 5 3 2 7 7 7 2 Spt20 family SPX PF03105.19 CDI84771.1 - 0.00082 19.4 5.4 0.00082 19.4 5.4 4.7 3 2 0 3 3 3 1 SPX domain DUF755 PF05501.11 CDI84771.1 - 0.0038 17.5 21.6 0.0038 17.5 21.6 9.0 9 0 0 9 9 9 2 Domain of unknown function (DUF755) DUF1180 PF06679.12 CDI84773.1 - 0.0024 18.3 7.7 0.0024 18.3 7.7 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1180) SSP160 PF06933.11 CDI84773.1 - 0.0059 14.9 15.4 0.0071 14.6 15.4 1.0 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 CDC27 PF09507.10 CDI84773.1 - 0.1 12.0 33.2 0.13 11.7 33.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SPX PF03105.19 CDI84774.1 - 0.0043 17.0 7.2 0.0053 16.7 7.2 1.0 1 0 0 1 1 1 1 SPX domain Orf78 PF06024.12 CDI84774.1 - 0.005 17.1 0.2 0.012 15.9 0.2 1.7 1 0 0 1 1 1 1 Orf78 (ac78) Peroxin-3 PF04882.12 CDI84774.1 - 0.036 13.1 4.3 0.041 12.9 4.3 1.1 1 0 0 1 1 1 0 Peroxin-3 DUF4834 PF16118.5 CDI84774.1 - 0.091 13.7 1.0 0.19 12.7 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TMEM132D_C PF15706.5 CDI84774.1 - 0.11 12.3 0.2 0.23 11.3 0.1 1.6 1 1 1 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Apt1 PF10351.9 CDI84774.1 - 1.2 7.9 12.3 1.6 7.5 12.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4813 PF16072.5 CDI84774.1 - 2.2 7.9 36.3 2.8 7.5 36.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Tmemb_cc2 PF10267.9 CDI84774.1 - 6.2 5.9 7.4 6.4 5.8 7.4 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Tht1 PF04163.12 CDI84776.1 - 0.013 14.3 0.4 0.016 14.0 0.4 1.2 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein Secretin_N_2 PF07655.13 CDI84776.1 - 0.013 16.1 5.7 0.058 13.9 0.9 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Hemerythrin PF01814.23 CDI84776.1 - 0.018 15.6 1.8 0.11 13.1 0.3 2.4 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain MRP-S31 PF15433.6 CDI84776.1 - 0.023 14.4 12.2 0.028 14.1 12.2 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 TFIIA PF03153.13 CDI84776.1 - 0.03 14.3 17.4 0.04 13.9 17.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI84776.1 - 0.18 10.5 7.9 0.21 10.3 7.9 1.1 1 0 0 1 1 1 0 Presenilin CCSAP PF15748.5 CDI84776.1 - 0.29 11.3 11.3 0.39 10.8 11.3 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated AAA PF00004.29 CDI84776.1 - 1.8 9.0 7.7 0.23 11.9 1.0 2.2 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) NABP PF07990.12 CDI84776.1 - 1.8 8.0 12.4 0.1 12.1 7.0 1.5 2 0 0 2 2 2 0 Nucleic acid binding protein NABP CSG2 PF16965.5 CDI84776.1 - 2.4 7.0 5.3 3 6.7 5.3 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator PTPRCAP PF15713.5 CDI84776.1 - 6.9 6.9 14.4 2.9 8.2 10.2 2.0 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated TFIIA PF03153.13 CDI84778.1 - 0.069 13.1 23.3 0.089 12.8 23.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3881 PF12997.7 CDI84778.1 - 0.43 9.8 2.6 0.56 9.4 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3881) LtrA PF06772.11 CDI84778.1 - 1.6 7.9 10.1 2.2 7.4 10.1 1.1 1 0 0 1 1 1 0 Bacterial low temperature requirement A protein (LtrA) Presenilin PF01080.17 CDI84778.1 - 3.2 6.4 7.9 3.8 6.2 7.9 1.2 1 0 0 1 1 1 0 Presenilin SUIM_assoc PF16619.5 CDI84778.1 - 3.4 7.8 14.8 15 5.7 8.3 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Macoilin PF09726.9 CDI84778.1 - 4 5.9 11.6 5.3 5.5 11.6 1.1 1 0 0 1 1 1 0 Macoilin family Draxin PF15550.6 CDI84778.1 - 4.3 7.1 9.3 6.2 6.6 9.3 1.2 1 0 0 1 1 1 0 Draxin Miga PF10265.9 CDI84778.1 - 6.9 5.5 10.9 8 5.3 10.9 1.1 1 0 0 1 1 1 0 Mitoguardin XRCC4 PF06632.12 CDI84778.1 - 8 5.2 10.3 11 4.7 10.3 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Sporozoite_P67 PF05642.11 CDI84779.1 - 0.00036 18.8 10.3 0.00047 18.4 10.3 1.2 1 0 0 1 1 1 1 Sporozoite P67 surface antigen HSP90 PF00183.18 CDI84779.1 - 0.053 12.4 4.6 0.067 12.1 4.6 1.2 1 0 0 1 1 1 0 Hsp90 protein Radial_spoke PF04712.12 CDI84779.1 - 0.073 12.0 8.6 0.12 11.3 8.6 1.3 1 0 0 1 1 1 0 Radial spokehead-like protein TRAP_alpha PF03896.16 CDI84779.1 - 0.64 9.2 11.2 0.042 13.0 4.1 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit SDA1 PF05285.12 CDI84779.1 - 0.66 9.3 11.5 0.016 14.6 2.7 2.0 2 0 0 2 2 2 0 SDA1 RR_TM4-6 PF06459.12 CDI84779.1 - 4.1 7.1 10.0 0.27 11.0 1.4 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Sigma70_ner PF04546.13 CDI84779.1 - 7.5 6.4 14.7 17 5.2 10.9 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region Presenilin PF01080.17 CDI84779.1 - 8.6 5.0 9.2 1.9 7.2 1.3 2.1 2 0 0 2 2 2 0 Presenilin Spt20 PF12090.8 CDI84780.1 - 0.27 10.8 6.8 0.25 10.9 6.8 1.1 1 0 0 1 1 1 0 Spt20 family MscS_TM PF12794.7 CDI84780.1 - 8.2 5.2 6.3 8 5.2 6.3 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DHC_N2 PF08393.13 CDI84781.1 - 4.6e-73 246.6 6.9 4.6e-73 246.6 6.9 1.7 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.7 CDI84782.1 - 2.7e-147 490.0 0.8 3e-146 486.6 0.0 3.0 4 0 0 4 4 3 1 Hydrolytic ATP binding site of dynein motor region AAA_8 PF12780.7 CDI84782.1 - 4.1e-89 298.3 0.0 9.6e-87 290.6 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 CDI84782.1 - 6.8e-67 224.5 0.9 3.5e-63 212.4 0.0 4.1 5 0 0 5 5 4 1 P-loop containing dynein motor region MT PF12777.7 CDI84782.1 - 1.1e-36 126.6 14.5 2.1e-36 125.7 14.5 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor DHC_N2 PF08393.13 CDI84782.1 - 6.1e-31 107.9 2.7 2.2e-30 106.1 0.0 3.2 3 1 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_5 PF07728.14 CDI84782.1 - 7.5e-31 107.0 0.0 3e-12 46.7 0.0 5.5 5 1 0 5 5 4 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 CDI84782.1 - 2.5e-25 89.0 1.5 1e-24 87.0 1.5 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 CDI84782.1 - 4.8e-23 81.3 0.1 1.6e-22 79.6 0.1 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CDI84782.1 - 3.7e-08 34.0 5.3 0.0061 16.9 0.0 6.0 5 1 1 6 6 5 1 AAA ATPase domain AAA_18 PF13238.6 CDI84782.1 - 1.3e-07 32.2 0.0 0.2 12.2 0.0 4.9 4 0 0 4 4 4 1 AAA domain AAA_22 PF13401.6 CDI84782.1 - 2.4e-07 31.1 1.6 0.0064 16.8 0.0 5.0 6 0 0 6 6 3 1 AAA domain AAA PF00004.29 CDI84782.1 - 2.9e-06 27.7 0.0 0.18 12.2 0.0 4.3 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 CDI84782.1 - 3.2e-06 27.7 0.4 0.0017 18.9 0.0 4.1 4 0 0 4 4 3 1 ABC transporter Mg_chelatase PF01078.21 CDI84782.1 - 4.4e-05 23.0 0.4 0.96 8.8 0.0 3.8 4 0 0 4 4 4 2 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CDI84782.1 - 7.1e-05 23.0 0.2 0.61 10.2 0.0 5.1 6 0 0 6 6 4 1 AAA domain AAA_30 PF13604.6 CDI84782.1 - 0.00016 21.5 2.1 4.9 6.8 0.0 3.8 4 0 0 4 4 3 0 AAA domain RNA_helicase PF00910.22 CDI84782.1 - 0.00025 21.4 0.0 14 6.1 0.0 4.4 4 0 0 4 4 3 0 RNA helicase Rad17 PF03215.15 CDI84782.1 - 0.00028 20.8 1.3 0.31 10.9 0.1 3.9 4 0 0 4 4 4 1 Rad17 P-loop domain AAA_29 PF13555.6 CDI84782.1 - 0.00029 20.5 0.1 0.057 13.2 0.0 3.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF815 PF05673.13 CDI84782.1 - 0.0014 17.8 0.0 0.1 11.8 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) TsaE PF02367.17 CDI84782.1 - 0.0052 16.8 0.1 0.26 11.3 0.0 2.9 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 CDI84782.1 - 0.0069 16.4 0.0 0.067 13.2 0.0 2.7 3 0 0 3 3 2 1 AAA domain G-alpha PF00503.20 CDI84782.1 - 0.012 14.8 0.6 0.044 13.0 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit TniB PF05621.11 CDI84782.1 - 0.016 14.6 0.0 0.13 11.7 0.0 2.5 3 0 0 3 3 2 0 Bacterial TniB protein Zeta_toxin PF06414.12 CDI84782.1 - 0.023 14.0 1.1 0.2 10.9 0.0 3.0 4 0 0 4 4 3 0 Zeta toxin Retrotrans_gag PF03732.17 CDI84782.1 - 0.033 14.4 4.5 0.46 10.8 0.4 4.0 4 0 0 4 4 3 0 Retrotransposon gag protein ATP_bind_1 PF03029.17 CDI84782.1 - 0.055 13.2 0.3 3 7.6 0.0 3.7 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 CDI84782.1 - 0.056 13.7 1.8 23 5.2 0.0 4.6 4 0 0 4 4 4 0 AAA domain AAA_19 PF13245.6 CDI84782.1 - 0.067 13.5 6.7 25 5.2 0.0 5.0 5 0 0 5 5 5 0 AAA domain DUF87 PF01935.17 CDI84782.1 - 0.074 13.1 3.3 8.8 6.3 0.0 3.7 3 0 0 3 3 3 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 CDI84782.1 - 0.17 11.8 0.0 4.3 7.2 0.0 3.2 3 0 0 3 3 3 0 RsgA GTPase Roc PF08477.13 CDI84782.1 - 0.19 12.0 0.6 0.75 10.0 0.0 2.4 3 0 0 3 3 1 0 Ras of Complex, Roc, domain of DAPkinase CHASE3 PF05227.13 CDI84782.1 - 0.25 11.3 15.7 0.35 10.8 11.8 2.6 2 0 0 2 2 2 0 CHASE3 domain GHL13 PF14883.6 CDI84782.1 - 0.4 9.7 4.4 6.6 5.7 0.7 2.5 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase family 13 BUD22 PF09073.10 CDI84782.1 - 1.2 8.4 10.2 1.9 7.7 10.2 1.2 1 0 0 1 1 1 0 BUD22 ISG65-75 PF11727.8 CDI84782.1 - 1.8 7.7 12.9 4.5 6.4 12.9 1.7 1 0 0 1 1 1 0 Invariant surface glycoprotein SMBP PF16785.5 CDI84782.1 - 2 8.6 9.9 6.7 7.0 9.9 1.9 1 0 0 1 1 1 0 Small metal-binding protein DUF4407 PF14362.6 CDI84782.1 - 2.2 7.6 13.1 4 6.7 13.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hrs_helical PF12210.8 CDI84782.1 - 3.6 8.2 8.0 0.24 12.0 1.8 2.3 2 0 0 2 2 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate AAA_23 PF13476.6 CDI84782.1 - 4.8 7.6 6.1 77 3.7 0.0 2.9 2 0 0 2 2 2 0 AAA domain Fib_alpha PF08702.10 CDI84782.1 - 7.7 6.7 12.3 0.95 9.6 4.2 3.1 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family PAT1 PF09770.9 CDI84784.1 - 0.016 13.5 43.6 0.02 13.2 43.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1697 PF08002.11 CDI84784.1 - 1.1 9.7 7.8 1.8 9.0 7.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1697) FUSC PF04632.12 CDI84784.1 - 3.4 6.1 12.1 3.8 5.9 12.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family FAM199X PF15814.5 CDI84785.1 - 0.016 14.3 29.6 0.02 14.0 29.6 1.1 1 0 0 1 1 1 0 Protein family FAM199X SDA1 PF05285.12 CDI84785.1 - 0.037 13.4 14.1 0.042 13.3 14.1 1.0 1 0 0 1 1 1 0 SDA1 Roughex PF06020.11 CDI84785.1 - 0.046 12.8 7.8 0.055 12.6 7.8 1.3 1 0 0 1 1 1 0 Drosophila roughex protein CCDC106 PF15794.5 CDI84785.1 - 0.053 13.2 26.7 0.082 12.6 26.7 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Suf PF05843.14 CDI84785.1 - 0.14 12.1 24.0 0.16 12.0 24.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 CDI84785.1 - 0.15 12.0 37.0 0.17 11.8 37.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CAC1F_C PF16885.5 CDI84785.1 - 0.29 10.8 16.7 0.33 10.6 16.7 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term eIF-3_zeta PF05091.12 CDI84785.1 - 0.32 9.9 16.7 0.35 9.8 16.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SprA-related PF12118.8 CDI84785.1 - 0.7 9.0 37.0 0.93 8.6 37.0 1.1 1 0 0 1 1 1 0 SprA-related family Utp14 PF04615.13 CDI84785.1 - 0.72 8.4 20.4 0.8 8.2 20.4 1.0 1 0 0 1 1 1 0 Utp14 protein PNISR PF15996.5 CDI84785.1 - 0.74 10.0 20.8 1.1 9.5 20.8 1.4 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF4407 PF14362.6 CDI84785.1 - 1 8.6 8.0 1 8.7 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SOBP PF15279.6 CDI84785.1 - 1.1 9.8 30.5 1.2 9.6 30.5 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Raftlin PF15250.6 CDI84785.1 - 1.1 7.9 21.5 1.3 7.7 21.5 1.0 1 0 0 1 1 1 0 Raftlin SMYLE_N PF18615.1 CDI84785.1 - 1.4 8.4 24.3 1.5 8.3 24.3 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Tmemb_cc2 PF10267.9 CDI84785.1 - 1.5 7.9 25.7 1.9 7.5 25.7 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein RR_TM4-6 PF06459.12 CDI84785.1 - 1.6 8.5 16.5 2 8.2 16.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF5427 PF10310.9 CDI84785.1 - 1.9 7.4 24.6 2.1 7.2 24.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF4175 PF13779.6 CDI84785.1 - 1.9 6.3 25.1 2.1 6.2 25.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) BAF1_ABF1 PF04684.13 CDI84785.1 - 1.9 7.4 27.0 2.3 7.2 27.0 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Presenilin PF01080.17 CDI84785.1 - 2.1 7.1 29.1 2.5 6.8 29.1 1.0 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 CDI84785.1 - 2.1 6.3 30.1 2.4 6.2 30.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein V_ATPase_I PF01496.19 CDI84785.1 - 2.3 6.0 14.7 2.7 5.8 14.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 CDI84785.1 - 2.4 6.4 19.6 2.7 6.2 19.6 1.0 1 0 0 1 1 1 0 CDC45-like protein LAP1C PF05609.12 CDI84785.1 - 2.5 7.1 24.3 2.8 6.9 24.3 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Ashwin PF15323.6 CDI84785.1 - 3 7.8 27.7 3.9 7.4 27.7 1.1 1 0 0 1 1 1 0 Developmental protein DUF4228 PF14009.6 CDI84785.1 - 3 8.2 17.4 4.4 7.6 17.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) PA26 PF04636.13 CDI84785.1 - 3.2 6.6 16.0 3.5 6.4 16.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF2126 PF09899.9 CDI84785.1 - 3.4 5.6 8.3 3.2 5.7 8.3 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) 5_nucleotid PF05761.14 CDI84785.1 - 3.4 6.4 12.0 3.8 6.3 12.0 1.1 1 0 0 1 1 1 0 5' nucleotidase family Serinc PF03348.15 CDI84785.1 - 4.5 6.1 16.0 5.1 5.9 16.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) ASD2 PF08687.11 CDI84785.1 - 4.6 6.7 21.7 6.1 6.3 21.7 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 RIFIN PF02009.16 CDI84785.1 - 4.7 7.0 14.1 5.2 6.9 14.1 1.1 1 0 0 1 1 1 0 Rifin SLC12 PF03522.15 CDI84785.1 - 4.9 6.1 22.5 5.7 5.9 22.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PI3K_1B_p101 PF10486.9 CDI84785.1 - 5.1 4.8 25.0 5.6 4.6 25.0 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF4820 PF16091.5 CDI84785.1 - 5.3 6.3 19.7 6.5 6.0 19.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF572 PF04502.13 CDI84785.1 - 6.4 6.3 22.9 7.3 6.1 22.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) PPP4R2 PF09184.11 CDI84785.1 - 6.8 6.2 22.8 8.3 5.9 22.8 1.1 1 0 0 1 1 1 0 PPP4R2 Zip PF02535.22 CDI84785.1 - 6.9 5.8 19.1 8.6 5.5 19.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Hamartin PF04388.12 CDI84785.1 - 7 5.2 26.8 7.6 5.1 26.8 1.0 1 0 0 1 1 1 0 Hamartin protein MAP70 PF07058.11 CDI84785.1 - 8.3 5.0 21.9 9.7 4.8 21.9 1.0 1 0 0 1 1 1 0 Microtubule-associated protein 70 Connexin PF00029.19 CDI84785.1 - 8.9 6.0 14.3 12 5.5 14.3 1.3 1 1 0 1 1 1 0 Connexin Membralin PF09746.9 CDI84785.1 - 9.8 5.1 14.5 12 4.9 14.5 1.2 1 0 0 1 1 1 0 Tumour-associated protein DUF4820 PF16091.5 CDI84786.1 - 0.00035 20.0 9.7 0.00035 20.0 9.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4820) DUF572 PF04502.13 CDI84786.1 - 1.1 8.8 15.8 1.7 8.2 15.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Mak16 PF04874.14 CDI84786.1 - 1.9 9.2 14.3 3.6 8.2 2.0 3.1 3 0 0 3 3 3 0 Mak16 protein C-terminal region ALMT PF11744.8 CDI84786.1 - 8.3 5.1 17.2 11 4.7 17.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter RskA PF10099.9 CDI84786.1 - 9.9 6.4 29.7 1.1 9.5 12.5 2.5 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Sulfate_transp PF00916.20 CDI84787.1 - 8.8e-36 123.5 2.5 1.1e-35 123.1 2.5 1.1 1 0 0 1 1 1 1 Sulfate permease family DUF587 PF04532.12 CDI84787.1 - 0.035 13.4 0.0 0.065 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF587) zf-MIZ PF02891.20 CDI84788.1 - 5.1e-16 58.2 8.2 7.2e-16 57.7 4.0 2.7 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger SAP PF02037.27 CDI84788.1 - 3.7e-07 29.7 0.0 8.8e-07 28.5 0.0 1.7 1 0 0 1 1 1 1 SAP domain PHD_2 PF13831.6 CDI84788.1 - 0.00019 20.9 4.3 0.00019 20.9 4.3 2.7 2 1 0 2 2 2 1 PHD-finger Prok-RING_1 PF14446.6 CDI84788.1 - 0.019 14.9 3.6 0.083 12.8 1.6 2.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PHD PF00628.29 CDI84788.1 - 0.02 14.8 16.2 0.067 13.1 6.9 2.9 2 0 0 2 2 2 0 PHD-finger zinc_ribbon_10 PF10058.9 CDI84788.1 - 3.6 7.4 6.3 13 5.6 0.2 2.8 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Trp_oprn_chp PF09534.10 CDI84790.1 - 0.24 11.2 3.5 0.51 10.1 0.2 2.1 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3381 PF11861.8 CDI84790.1 - 0.25 11.1 23.8 0.014 15.2 12.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) DUF4407 PF14362.6 CDI84790.1 - 2.6 7.3 26.4 3.8 6.8 26.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2400 PF09674.10 CDI84790.1 - 8.7 6.3 11.2 13 5.7 11.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2400) AbLIM_anchor PF16182.5 CDI84791.1 - 0.0031 17.4 2.2 0.0035 17.2 2.2 1.1 1 0 0 1 1 1 1 Putative adherens-junction anchoring region of AbLIM PIEZO PF15917.5 CDI84791.1 - 0.026 14.0 11.0 0.037 13.5 11.0 1.1 1 0 0 1 1 1 0 Piezo PTPRCAP PF15713.5 CDI84791.1 - 0.11 12.8 11.8 0.19 12.0 11.8 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SR-25 PF10500.9 CDI84791.1 - 0.13 11.9 11.6 0.18 11.4 11.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI84791.1 - 0.13 11.8 26.5 0.17 11.4 26.5 1.1 1 0 0 1 1 1 0 Spt20 family EPL1 PF10513.9 CDI84791.1 - 0.17 12.3 6.3 0.22 11.9 6.3 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like Sin_N PF04801.13 CDI84791.1 - 0.18 11.0 11.9 0.21 10.8 11.9 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region CIAPIN1 PF05093.13 CDI84791.1 - 0.2 12.2 5.6 0.36 11.4 5.6 1.5 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis MMR1 PF08505.10 CDI84791.1 - 0.24 11.7 10.6 0.3 11.4 10.6 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein NST1 PF13945.6 CDI84791.1 - 0.34 11.0 15.0 0.48 10.5 15.0 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Presenilin PF01080.17 CDI84791.1 - 0.39 9.4 10.2 0.47 9.2 10.2 1.2 1 0 0 1 1 1 0 Presenilin GREB1 PF15782.5 CDI84791.1 - 0.41 7.7 12.7 0.46 7.5 12.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Miga PF10265.9 CDI84791.1 - 0.45 9.4 11.5 0.49 9.3 11.5 1.1 1 0 0 1 1 1 0 Mitoguardin Lin-8 PF03353.15 CDI84791.1 - 0.49 9.9 12.0 0.59 9.6 12.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PAT1 PF09770.9 CDI84791.1 - 0.58 8.4 14.6 0.6 8.3 14.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NUDE_C PF04880.13 CDI84791.1 - 0.65 10.5 19.9 1.1 9.7 19.9 1.5 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region Hid1 PF12722.7 CDI84791.1 - 1.1 7.3 9.4 1.2 7.1 9.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Cellulose_synt PF03552.14 CDI84791.1 - 1.1 7.6 3.4 1.4 7.3 3.4 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF572 PF04502.13 CDI84791.1 - 1.5 8.4 14.0 1.9 8.1 14.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SLC12 PF03522.15 CDI84791.1 - 3.3 6.6 9.8 3.9 6.4 9.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Ndc1_Nup PF09531.10 CDI84791.1 - 4.2 5.9 15.4 4.5 5.8 15.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup UPF0560 PF10577.9 CDI84791.1 - 5 5.5 14.9 6 5.2 14.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TERB2 PF15101.6 CDI84791.1 - 7.5 6.5 15.5 10 6.1 15.5 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SWI-SNF_Ssr4 PF08549.10 CDI84791.1 - 7.9 5.0 23.8 9.6 4.7 23.8 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Neur_chan_memb PF02932.16 CDI84791.1 - 10 6.1 8.4 13 5.8 8.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Wzy_C PF04932.15 CDI84792.1 - 1.9e-05 24.4 0.0 0.0024 17.5 2.0 2.2 1 1 1 2 2 2 1 O-Antigen ligase Connexin PF00029.19 CDI84792.1 - 8.1e-05 22.5 10.6 8.1e-05 22.5 10.6 2.2 1 1 1 2 2 2 1 Connexin CBP_BcsG PF11658.8 CDI84792.1 - 0.00033 19.2 13.8 0.00033 19.2 13.8 2.3 1 1 1 2 2 1 1 Cellulose biosynthesis protein BcsG CobT PF06213.12 CDI84792.1 - 0.0005 19.6 12.2 0.0005 19.6 12.2 2.2 2 0 0 2 2 2 1 Cobalamin biosynthesis protein CobT Phage_holin_3_6 PF07332.11 CDI84792.1 - 0.001 19.1 5.2 0.001 19.1 5.2 2.6 2 1 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III V_ATPase_I PF01496.19 CDI84792.1 - 0.0027 15.7 21.3 0.0027 15.7 21.3 2.2 1 1 1 2 2 2 1 V-type ATPase 116kDa subunit family TMEM72 PF16054.5 CDI84792.1 - 0.0036 17.0 3.0 0.0046 16.7 1.9 1.7 1 1 1 2 2 2 1 Transmembrane protein family 72 O-antigen_lig PF13425.6 CDI84792.1 - 0.0046 15.8 9.4 0.0046 15.8 9.4 2.1 1 1 1 2 2 2 1 O-antigen ligase like membrane protein N6_N4_Mtase PF01555.18 CDI84792.1 - 0.015 15.0 0.0 0.069 12.8 0.0 1.9 1 1 0 1 1 1 0 DNA methylase SpoIIIAH PF12685.7 CDI84792.1 - 0.022 14.6 23.3 1.8 8.4 23.3 2.3 1 1 0 1 1 1 0 SpoIIIAH-like protein DUF4131 PF13567.6 CDI84792.1 - 0.025 14.3 21.9 0.033 13.8 9.4 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF2828 PF11443.8 CDI84792.1 - 0.038 12.1 23.8 0.011 13.9 13.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Pex24p PF06398.11 CDI84792.1 - 0.045 12.7 13.8 0.38 9.7 13.8 2.1 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin SRP-alpha_N PF04086.13 CDI84792.1 - 0.053 13.5 24.1 0.081 12.8 24.1 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Spore_coat_CotO PF14153.6 CDI84792.1 - 0.062 13.2 37.6 0.064 13.2 20.9 2.1 2 0 0 2 2 2 0 Spore coat protein CotO ODV-E18 PF10717.9 CDI84792.1 - 0.077 12.9 0.3 0.077 12.9 0.3 3.1 2 1 0 2 2 1 0 Occlusion-derived virus envelope protein ODV-E18 CitMHS PF03600.16 CDI84792.1 - 0.081 12.1 0.9 0.13 11.4 0.9 1.5 1 1 0 1 1 1 0 Citrate transporter Polysacc_synt PF01943.17 CDI84792.1 - 0.12 11.7 14.8 0.11 11.8 9.2 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Trp_oprn_chp PF09534.10 CDI84792.1 - 0.15 11.9 12.8 61 3.3 12.8 2.9 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Choline_transpo PF04515.12 CDI84792.1 - 0.2 10.8 2.6 0.42 9.8 2.5 1.7 1 1 0 1 1 1 0 Plasma-membrane choline transporter Peptidase_M50B PF13398.6 CDI84792.1 - 0.22 11.2 8.1 0.11 12.1 4.6 1.9 2 0 0 2 2 2 0 Peptidase M50B-like SARAF PF06682.12 CDI84792.1 - 0.26 10.9 31.2 0.02 14.6 15.2 2.4 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2052 PF09747.9 CDI84792.1 - 0.38 10.9 25.1 0.2 11.8 13.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) 7tm_1 PF00001.21 CDI84792.1 - 0.51 9.6 18.7 3.1 7.0 1.1 2.7 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) Peptidase_S64 PF08192.11 CDI84792.1 - 0.59 8.5 32.5 0.79 8.1 32.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 TCP PF03634.13 CDI84792.1 - 0.61 10.6 33.2 0.12 13.0 4.7 2.2 2 0 0 2 2 2 0 TCP family transcription factor ATG22 PF11700.8 CDI84792.1 - 1.3 7.6 13.7 0.05 12.2 6.2 2.1 2 0 0 2 2 2 0 Vacuole effluxer Atg22 like Ureide_permease PF07168.11 CDI84792.1 - 1.4 7.6 11.6 0.078 11.7 2.5 2.3 2 0 0 2 2 2 0 Ureide permease PAP2_3 PF14378.6 CDI84792.1 - 1.5 8.5 9.0 0.092 12.4 2.1 2.3 2 1 0 2 2 2 0 PAP2 superfamily RskA PF10099.9 CDI84792.1 - 1.6 9.0 38.8 0.086 13.1 10.5 3.2 1 1 0 2 2 1 0 Anti-sigma-K factor rskA Nucleoside_tran PF01733.18 CDI84792.1 - 1.8 7.9 17.9 0.012 15.0 7.5 2.0 1 1 0 2 2 2 0 Nucleoside transporter 7TM_GPCR_Srw PF10324.9 CDI84792.1 - 1.9 7.7 10.7 4.1 6.6 10.7 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw SID-1_RNA_chan PF13965.6 CDI84792.1 - 2.7 6.3 24.7 0.041 12.3 11.0 2.3 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 DUF1430 PF07242.11 CDI84792.1 - 3 8.1 12.9 1.4 9.3 7.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) RPN2_C PF18004.1 CDI84792.1 - 3.1 7.7 25.6 0.75 9.7 16.2 2.2 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain FA_desaturase PF00487.24 CDI84792.1 - 3.2 7.5 5.4 4.1 7.2 3.6 2.0 1 1 1 2 2 2 0 Fatty acid desaturase TFB6 PF17110.5 CDI84792.1 - 3.3 7.4 17.6 7.8 6.2 11.5 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF2126 PF09899.9 CDI84792.1 - 3.5 5.6 24.6 0.18 9.8 12.1 2.0 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) DUF3169 PF11368.8 CDI84792.1 - 3.5 7.1 10.7 4.6 6.7 4.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) NicO PF03824.16 CDI84792.1 - 4 6.7 14.7 5.7 6.2 0.8 2.7 1 1 1 2 2 2 0 High-affinity nickel-transport protein Amastin PF07344.11 CDI84792.1 - 4.4 7.1 8.6 1.3 8.9 0.2 2.8 2 1 1 3 3 3 0 Amastin surface glycoprotein CopD PF05425.13 CDI84792.1 - 5.2 7.5 24.1 0.33 11.4 1.9 4.2 3 1 1 4 4 3 0 Copper resistance protein D tRNA_anti-like PF12869.7 CDI84792.1 - 6.3 6.4 20.3 0.9 9.1 10.2 3.2 1 1 1 2 2 2 0 tRNA_anti-like DUF3278 PF11683.8 CDI84792.1 - 7.1 6.7 12.6 1 9.5 5.9 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3278) AIF_C PF14721.6 CDI84792.1 - 8.3 6.8 24.1 0.22 11.9 8.3 2.6 2 1 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Peptidase_U57 PF05582.12 CDI84792.1 - 9.2 5.4 22.4 0.66 9.2 12.3 2.1 2 0 0 2 2 2 0 YabG peptidase U57 AF-4 PF05110.13 CDI84792.1 - 9.3 4.2 43.4 0.31 9.1 14.0 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein DUF4834 PF16118.5 CDI84793.1 - 0.0056 17.6 6.0 0.0056 17.6 6.0 6.8 5 2 1 6 6 6 2 Domain of unknown function (DUF4834) AT_hook PF02178.19 CDI84793.1 - 0.15 12.0 3.5 0.4 10.7 3.5 1.8 1 0 0 1 1 1 0 AT hook motif Gpi16 PF04113.14 CDI84795.1 - 2.4e-14 52.7 6.2 9.5e-08 30.9 4.2 4.0 2 2 1 4 4 4 2 Gpi16 subunit, GPI transamidase component DUF4834 PF16118.5 CDI84795.1 - 2.3e-06 28.5 17.4 8.3e-05 23.5 0.1 4.2 4 0 0 4 4 4 2 Domain of unknown function (DUF4834) DUF1980 PF09323.10 CDI84795.1 - 5e-05 23.3 0.3 5e-05 23.3 0.3 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF1980) DUF2722 PF10846.8 CDI84795.1 - 0.0003 19.9 1.0 0.0003 19.9 1.0 4.1 4 0 0 4 4 3 3 Protein of unknown function (DUF2722) SARAF PF06682.12 CDI84795.1 - 0.00085 19.1 8.6 0.12 12.0 2.0 2.7 2 1 0 2 2 2 2 SOCE-associated regulatory factor of calcium homoeostasis DUF3487 PF11990.8 CDI84795.1 - 0.0044 16.9 2.8 0.93 9.4 0.2 2.9 2 0 0 2 2 2 2 Protein of unknown function (DUF3487) EPL1 PF10513.9 CDI84795.1 - 0.0087 16.5 0.6 0.0087 16.5 0.6 3.9 4 0 0 4 4 4 1 Enhancer of polycomb-like SID-1_RNA_chan PF13965.6 CDI84795.1 - 0.015 13.7 4.6 0.026 12.9 2.2 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 ECSCR PF15820.5 CDI84795.1 - 0.21 11.4 5.8 0.41 10.5 5.8 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Connexin PF00029.19 CDI84795.1 - 0.23 11.2 12.3 0.32 10.7 1.5 3.3 4 0 0 4 4 4 0 Connexin FAM176 PF14851.6 CDI84795.1 - 1.8 8.2 8.8 0.69 9.6 0.7 3.0 3 0 0 3 3 3 0 FAM176 family Protocadherin PF08374.11 CDI84795.1 - 2.9 7.8 13.2 0.042 13.8 4.2 2.4 3 0 0 3 3 3 0 Protocadherin DUF2371 PF10177.9 CDI84795.1 - 4.2 7.6 12.2 0.47 10.6 0.6 3.6 4 1 0 4 4 4 0 Uncharacterised conserved protein (DUF2371) BNR_3 PF13859.6 CDI84795.1 - 4.2 6.6 6.9 2.3 7.4 3.9 2.0 2 0 0 2 2 2 0 BNR repeat-like domain 2OG-FeII_Oxy_5 PF13759.6 CDI84795.1 - 4.6 7.7 0.0 4.6 7.7 0.0 4.1 5 0 0 5 5 4 0 Putative 2OG-Fe(II) oxygenase Neur_chan_memb PF02932.16 CDI84795.1 - 9.5 6.2 23.7 4.4 7.3 1.2 2.8 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SR-25 PF10500.9 CDI84796.1 - 6.7e-05 22.6 27.3 6.7e-05 22.6 27.3 2.1 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI84796.1 - 0.016 15.2 43.5 0.017 15.2 43.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2615 PF11027.8 CDI84796.1 - 0.018 15.2 1.4 0.018 15.2 1.4 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF2615) HemX PF04375.14 CDI84796.1 - 0.052 12.8 27.9 0.074 12.3 27.9 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4207 PF13904.6 CDI84796.1 - 0.062 13.0 31.9 0.1 12.2 31.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4207) eIF-3_zeta PF05091.12 CDI84796.1 - 0.31 9.9 17.3 0.33 9.9 17.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PA26 PF04636.13 CDI84796.1 - 0.64 8.9 20.9 0.71 8.7 20.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Conotoxin PF02950.17 CDI84796.1 - 0.97 10.5 15.3 5.5 8.1 0.6 2.4 2 0 0 2 2 2 0 Conotoxin RR_TM4-6 PF06459.12 CDI84796.1 - 3.5 7.4 17.9 4.2 7.1 17.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tau95_N PF17682.1 CDI84796.1 - 7.8 6.7 14.1 14 5.9 13.7 1.6 1 1 1 2 2 2 0 Tau95 Triple barrel domain RskA PF10099.9 CDI84797.1 - 0.002 18.5 6.4 0.002 18.5 6.4 7.1 3 2 2 5 5 5 2 Anti-sigma-K factor rskA Lin-8 PF03353.15 CDI84797.1 - 0.0033 17.0 15.5 0.0033 17.0 15.5 4.0 4 0 0 4 4 4 2 Ras-mediated vulval-induction antagonist Peptidase_C2 PF00648.21 CDI84797.1 - 0.009 15.1 1.2 0.009 15.1 1.2 3.0 2 1 1 3 3 3 1 Calpain family cysteine protease DUF2828 PF11443.8 CDI84797.1 - 2 6.4 31.8 0.052 11.6 8.9 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF2828) Na_trans_assoc PF06512.13 CDI84797.1 - 5.1 7.3 16.5 4.2 7.6 2.4 3.0 3 0 0 3 3 3 0 Sodium ion transport-associated CDC45 PF02724.14 CDI84798.1 - 0.00057 18.3 18.1 0.00059 18.3 18.1 1.1 1 0 0 1 1 1 1 CDC45-like protein PAT1 PF09770.9 CDI84798.1 - 0.036 12.4 43.3 0.04 12.2 43.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DDRGK PF09756.9 CDI84798.1 - 0.073 12.7 28.0 0.11 12.0 28.0 1.3 1 0 0 1 1 1 0 DDRGK domain Tim54 PF11711.8 CDI84798.1 - 0.35 9.6 19.8 0.52 9.0 19.8 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NARP1 PF12569.8 CDI84798.1 - 0.63 8.9 22.0 0.84 8.5 22.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 eIF3_subunit PF08597.10 CDI84798.1 - 1.4 8.8 19.5 1.9 8.4 19.5 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF963 PF06131.11 CDI84798.1 - 1.5 8.3 98.7 0.034 13.6 24.5 4.8 1 1 3 4 4 4 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) eIF-3_zeta PF05091.12 CDI84798.1 - 3.1 6.7 32.6 4.9 6.0 32.6 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CCSAP PF15748.5 CDI84798.1 - 5.3 7.1 32.4 10 6.2 32.4 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated O-antigen_lig PF13425.6 CDI84799.1 - 3.2 6.4 10.2 4.2 6.1 10.2 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Erv26 PF04148.13 CDI84799.1 - 6.7 6.5 9.5 5.6 6.7 1.5 2.2 2 0 0 2 2 2 0 Transmembrane adaptor Erv26 FCP1_C PF09309.10 CDI84799.1 - 8.9 6.1 30.1 6.7 6.5 15.4 2.1 2 0 0 2 2 2 0 FCP1, C-terminal tRNA_synt_1c_R2 PF04557.15 CDI84799.1 - 9.3 7.2 21.1 0.82 10.6 3.3 2.5 2 1 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Thioredoxin PF00085.20 CDI84801.1 - 2.8e-06 27.3 0.0 0.08 12.9 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Glutaredoxin PF00462.24 CDI84801.1 - 0.00026 21.1 0.7 0.00096 19.3 0.0 2.4 3 0 0 3 3 3 1 Glutaredoxin OST3_OST6 PF04756.13 CDI84801.1 - 0.0007 19.0 0.0 0.19 11.1 0.0 2.3 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family DUF3785 PF12653.7 CDI84801.1 - 0.0042 17.2 0.0 0.0073 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3785) TraF PF13728.6 CDI84801.1 - 0.01 15.7 0.0 0.039 13.8 0.0 1.9 2 0 0 2 2 2 0 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 CDI84801.1 - 0.024 14.7 0.0 3.4 7.8 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin domain RVP_2 PF08284.11 CDI84803.1 - 1.6e-09 37.6 0.0 2.6e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CDI84803.1 - 1.5e-07 31.9 0.0 4.8e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI84803.1 - 6.9e-07 29.7 0.0 4.9e-06 27.0 0.0 2.3 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 CDI84803.1 - 0.031 14.1 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.20 CDI84803.1 - 0.058 13.7 0.0 0.15 12.4 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease Ephrin_rec_like PF07699.13 CDI84805.1 - 1.6e-07 31.0 10.7 6.4e-06 25.8 1.0 3.3 2 1 1 3 3 3 2 Putative ephrin-receptor like Gliadin PF13016.6 CDI84805.1 - 0.4 11.1 3.3 6.3 7.3 0.4 2.9 2 0 0 2 2 2 0 Cys-rich Gliadin N-terminal NHL PF01436.21 CDI84806.1 - 2.1e-09 36.9 0.2 0.98 9.6 0.0 5.9 5 0 0 5 5 5 3 NHL repeat SGL PF08450.12 CDI84806.1 - 1e-08 35.1 0.1 2.3e-06 27.4 0.0 2.3 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Lactonase PF10282.9 CDI84806.1 - 0.00011 21.6 0.0 0.00024 20.5 0.0 1.5 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller F5_F8_type_C PF00754.25 CDI84806.1 - 0.0012 19.0 0.1 0.0028 17.8 0.1 1.6 1 0 0 1 1 1 1 F5/8 type C domain PQQ_2 PF13360.6 CDI84806.1 - 0.016 14.8 0.4 0.038 13.6 0.4 1.6 1 0 0 1 1 1 0 PQQ-like domain Arylesterase PF01731.20 CDI84806.1 - 0.083 13.1 0.0 0.47 10.7 0.0 2.3 1 1 1 2 2 2 0 Arylesterase Ribosomal_60s PF00428.19 CDI84807.1 - 0.005 17.4 22.1 0.005 17.4 22.1 3.1 2 1 1 3 3 3 1 60s Acidic ribosomal protein PAT1 PF09770.9 CDI84807.1 - 0.22 9.7 55.3 0.25 9.6 55.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SfLAP PF11139.8 CDI84807.1 - 1.6 8.1 10.9 1.7 8.0 9.9 1.5 1 1 0 1 1 1 0 Sap, sulfolipid-1-addressing protein Hydrolase_3 PF08282.12 CDI84807.1 - 1.7 8.3 10.8 2.3 7.9 10.8 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF4776 PF16003.5 CDI84807.1 - 2.6 6.9 26.6 2.6 6.9 26.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) DUF4813 PF16072.5 CDI84807.1 - 7.9 6.1 29.3 11 5.6 29.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) DUF3097 PF11296.8 CDI84807.1 - 9.4 5.4 10.0 16 4.6 10.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3097) Utp14 PF04615.13 CDI84808.1 - 0.0041 15.8 27.8 0.0046 15.6 27.8 1.0 1 0 0 1 1 1 1 Utp14 protein DUF4064 PF13273.6 CDI84808.1 - 0.019 15.2 4.6 0.019 15.2 4.6 3.1 2 1 0 2 2 1 0 Protein of unknown function (DUF4064) CDC45 PF02724.14 CDI84808.1 - 0.038 12.3 29.6 0.046 12.0 29.6 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF3377 PF11857.8 CDI84808.1 - 0.041 13.8 0.4 0.17 11.8 0.4 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Macoilin PF09726.9 CDI84808.1 - 0.083 11.4 33.3 0.1 11.1 33.3 1.2 1 0 0 1 1 1 0 Macoilin family LAP1C PF05609.12 CDI84808.1 - 0.14 11.2 40.8 0.19 10.8 40.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Dapper PF15268.6 CDI84808.1 - 0.21 10.4 36.8 0.25 10.1 36.8 1.1 1 0 0 1 1 1 0 Dapper RIFIN PF02009.16 CDI84808.1 - 0.45 10.4 41.4 1.7 8.4 41.4 1.7 1 1 0 1 1 1 0 Rifin GREB1 PF15782.5 CDI84808.1 - 0.47 7.5 39.7 0.57 7.2 39.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Na_trans_assoc PF06512.13 CDI84808.1 - 0.53 10.5 21.1 0.62 10.3 21.1 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated SLC12 PF03522.15 CDI84808.1 - 0.57 9.1 39.6 0.8 8.7 39.6 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Draxin PF15550.6 CDI84808.1 - 1 9.1 26.6 1.4 8.7 26.6 1.1 1 0 0 1 1 1 0 Draxin Spc7_N PF15402.6 CDI84808.1 - 1.2 7.3 26.9 1.5 7.0 26.9 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 ODV-E18 PF10717.9 CDI84808.1 - 1.5 8.8 18.5 0.59 10.0 15.0 1.8 1 1 1 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 LMBR1 PF04791.16 CDI84808.1 - 2.1 7.2 29.0 3.2 6.5 29.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Hid1 PF12722.7 CDI84808.1 - 2.3 6.2 38.5 3.2 5.8 38.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SPX PF03105.19 CDI84808.1 - 3.5 7.5 31.6 4.4 7.1 31.6 1.1 1 0 0 1 1 1 0 SPX domain Asp-B-Hydro_N PF05279.11 CDI84808.1 - 7.2 6.6 28.7 8.4 6.4 28.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SART-1 PF03343.13 CDI84811.1 - 0.047 12.3 28.5 0.057 12.0 28.5 1.0 1 0 0 1 1 1 0 SART-1 family Hamartin PF04388.12 CDI84811.1 - 0.81 8.3 31.8 1 8.0 31.8 1.0 1 0 0 1 1 1 0 Hamartin protein VIR_N PF15912.5 CDI84811.1 - 1.1 8.8 23.5 1.4 8.5 16.7 2.1 2 0 0 2 2 2 0 Virilizer, N-terminal DUF4551 PF15087.6 CDI84811.1 - 1.2 7.9 31.0 1.6 7.5 31.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Hid1 PF12722.7 CDI84811.1 - 3.5 5.6 31.4 4.6 5.2 31.4 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SR-25 PF10500.9 CDI84811.1 - 6.4 6.3 39.4 1.4 8.5 25.9 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein LAP1C PF05609.12 CDI84811.1 - 6.7 5.7 32.7 8.7 5.3 32.7 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Syja_N PF02383.18 CDI84814.1 - 1.1e-12 47.9 7.1 1.1e-12 47.9 7.1 4.3 2 2 1 3 3 1 1 SacI homology domain RskA PF10099.9 CDI84814.1 - 0.00024 21.5 6.5 0.00024 21.5 6.5 5.7 2 2 2 4 4 3 3 Anti-sigma-K factor rskA Ribosomal_60s PF00428.19 CDI84814.1 - 0.0005 20.6 27.1 0.0007 20.1 6.8 3.1 3 0 0 3 3 3 2 60s Acidic ribosomal protein Spt20 PF12090.8 CDI84814.1 - 0.0016 18.1 11.0 0.0016 18.1 11.0 6.3 3 2 2 5 5 1 1 Spt20 family SLC12 PF03522.15 CDI84814.1 - 0.0048 16.0 53.6 0.028 13.5 23.6 3.2 3 0 0 3 3 3 3 Solute carrier family 12 DUF1645 PF07816.11 CDI84814.1 - 0.0064 17.1 9.7 0.0064 17.1 9.7 4.6 3 1 0 3 3 3 1 Protein of unknown function (DUF1645) Velvet PF11754.8 CDI84814.1 - 0.0068 16.4 0.5 0.0068 16.4 0.5 4.2 1 1 2 3 3 2 1 Velvet factor DUF4834 PF16118.5 CDI84814.1 - 0.021 15.8 5.9 0.021 15.8 5.9 7.5 4 3 1 5 5 2 0 Domain of unknown function (DUF4834) PAT1 PF09770.9 CDI84814.1 - 0.075 11.3 93.3 0.09 11.0 21.3 3.1 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 Lin-8 PF03353.15 CDI84814.1 - 0.082 12.5 80.4 0.17 11.4 6.2 3.3 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist OAD_gamma PF04277.13 CDI84814.1 - 0.2 12.3 0.0 0.2 12.3 0.0 5.7 6 0 0 6 6 6 0 Oxaloacetate decarboxylase, gamma chain Isy1 PF06246.12 CDI84814.1 - 0.27 10.8 46.4 0.24 11.0 8.4 3.4 3 0 0 3 3 3 0 Isy1-like splicing family Trefoil PF00088.18 CDI84814.1 - 1.8 8.5 6.3 3.3 7.7 1.8 3.2 3 0 0 3 3 3 0 Trefoil (P-type) domain CNDH2_C PF16858.5 CDI84814.1 - 2.7 7.8 56.5 0.66 9.8 13.0 3.2 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PA26 PF04636.13 CDI84814.1 - 4.5 6.1 41.4 0.78 8.6 9.8 3.2 3 0 0 3 3 3 0 PA26 p53-induced protein (sestrin) Coiled PF05710.12 CDI84814.1 - 8.4 7.3 26.3 6.2 7.7 13.1 2.6 2 0 0 2 2 2 0 Coiled coil SR-25 PF10500.9 CDI84816.1 - 2.2e-07 30.7 32.1 4.2e-07 29.8 9.9 6.9 6 1 0 6 6 6 3 Nuclear RNA-splicing-associated protein MMS1_N PF10433.9 CDI84816.1 - 1.8e-05 23.6 1.1 3e-05 22.8 0.2 1.8 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term PelD_GGDEF PF16963.5 CDI84816.1 - 0.0021 17.8 0.5 0.0053 16.5 0.5 1.6 1 0 0 1 1 1 1 PelD GGDEF domain MAGE_N PF12440.8 CDI84816.1 - 0.014 16.1 1.1 0.014 16.1 1.1 8.2 3 3 1 6 6 6 0 Melanoma associated antigen family N terminal Pkinase PF00069.25 CDI84818.1 - 5.7e-10 39.0 0.0 1e-08 34.9 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.6 CDI84818.1 - 4.2e-07 29.6 0.0 0.006 15.9 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_Tyr PF07714.17 CDI84818.1 - 1.9e-05 24.1 0.0 4.3e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Macoilin PF09726.9 CDI84818.1 - 2.8 6.4 7.8 4.3 5.8 7.8 1.2 1 0 0 1 1 1 0 Macoilin family Lin-8 PF03353.15 CDI84818.1 - 3.4 7.1 13.9 6.7 6.2 13.9 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist rRNA_processing PF08524.11 CDI84819.1 - 1.5 8.8 17.0 2.6 8.1 17.0 1.2 1 0 0 1 1 1 0 rRNA processing PA26 PF04636.13 CDI84819.1 - 4.4 6.1 9.9 8 5.3 9.9 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SelP_N PF04592.14 CDI84819.1 - 7.3 5.9 13.6 11 5.3 13.6 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RskA PF10099.9 CDI84819.1 - 8 6.7 41.1 0.019 15.2 13.4 2.6 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Raftlin PF15250.6 CDI84820.1 - 0.021 13.6 3.9 0.027 13.2 3.9 1.1 1 0 0 1 1 1 0 Raftlin DUF3246 PF11596.8 CDI84820.1 - 0.025 14.0 0.2 0.028 13.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) 7TM_GPCR_Srv PF10323.9 CDI84820.1 - 0.053 12.9 0.8 3.6 6.9 0.2 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv RseA_C PF03873.13 CDI84820.1 - 0.081 13.2 1.3 0.081 13.2 1.3 3.3 3 0 0 3 3 2 0 Anti sigma-E protein RseA, C-terminal domain 7TM_transglut PF14402.6 CDI84820.1 - 0.084 12.3 0.5 0.17 11.3 0.5 1.4 1 0 0 1 1 1 0 7 transmembrane helices usually fused to an inactive transglutaminase DUF4407 PF14362.6 CDI84820.1 - 0.14 11.5 22.6 0.16 11.3 22.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Lin-8 PF03353.15 CDI84820.1 - 0.87 9.1 13.2 1.2 8.6 13.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist INO80_Ies4 PF08193.11 CDI84820.1 - 1.6 8.7 8.4 2.1 8.3 8.4 1.1 1 0 0 1 1 1 0 INO80 complex subunit Ies4 BAF1_ABF1 PF04684.13 CDI84820.1 - 1.8 7.5 16.8 2.3 7.2 16.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Ndc1_Nup PF09531.10 CDI84820.1 - 2 7.0 10.9 2.3 6.8 10.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PPP4R2 PF09184.11 CDI84820.1 - 2.2 7.8 6.8 2.6 7.5 6.8 1.1 1 0 0 1 1 1 0 PPP4R2 Dehydrin PF00257.19 CDI84820.1 - 2.6 8.6 5.6 18 5.9 0.2 2.1 2 0 0 2 2 2 0 Dehydrin IER PF05760.12 CDI84820.1 - 6.5 7.0 15.2 9.1 6.5 15.2 1.2 1 0 0 1 1 1 0 Immediate early response protein (IER) Cwf_Cwc_15 PF04889.12 CDI84820.1 - 7.8 6.2 20.3 13 5.4 20.3 1.3 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein E1-E2_ATPase PF00122.20 CDI84821.1 - 7.3e-12 45.2 4.2 7.3e-12 45.2 4.2 3.2 3 1 0 3 3 3 1 E1-E2 ATPase DUF3332 PF11810.8 CDI84821.1 - 0.00015 21.5 15.4 0.00025 20.7 15.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3332) Rtf2 PF04641.12 CDI84821.1 - 0.00038 19.9 14.0 0.00042 19.8 14.0 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger DUF572 PF04502.13 CDI84821.1 - 0.0012 18.6 15.6 0.0014 18.3 15.6 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF2201_N PF13203.6 CDI84821.1 - 0.0015 18.2 8.7 0.0035 17.0 8.7 1.5 1 1 0 1 1 1 1 Putative metallopeptidase domain RskA PF10099.9 CDI84821.1 - 0.0016 18.8 11.5 15 5.8 11.5 2.7 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Coilin_N PF15862.5 CDI84821.1 - 0.0016 18.2 4.5 0.0016 18.2 4.5 2.2 1 1 1 2 2 1 1 Coilin N-terminus Presenilin PF01080.17 CDI84821.1 - 0.0029 16.4 26.1 0.0044 15.8 26.1 1.3 1 0 0 1 1 1 1 Presenilin GREB1 PF15782.5 CDI84821.1 - 0.0038 14.5 21.4 0.0046 14.2 21.4 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer AAA_11 PF13086.6 CDI84821.1 - 0.0069 16.2 21.0 0.011 15.5 21.0 1.3 1 0 0 1 1 1 1 AAA domain RR_TM4-6 PF06459.12 CDI84821.1 - 0.0076 16.1 23.2 0.0097 15.8 23.2 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Senescence_reg PF04520.13 CDI84821.1 - 0.011 16.6 14.5 0.015 16.1 14.5 1.2 1 0 0 1 1 1 0 Senescence regulator AAA_23 PF13476.6 CDI84821.1 - 0.043 14.3 32.5 0.064 13.8 32.5 1.4 1 0 0 1 1 1 0 AAA domain FAM60A PF15396.6 CDI84821.1 - 0.071 13.1 18.5 0.1 12.6 18.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A GAGA_bind PF06217.12 CDI84821.1 - 0.09 13.0 18.3 0.1 12.8 18.3 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family PAT1 PF09770.9 CDI84821.1 - 0.11 10.8 41.3 0.13 10.5 41.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4045 PF13254.6 CDI84821.1 - 0.21 11.2 20.6 0.26 10.9 20.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Lin-8 PF03353.15 CDI84821.1 - 0.29 10.6 29.8 0.38 10.3 29.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist V_ATPase_I PF01496.19 CDI84821.1 - 0.38 8.6 23.2 0.49 8.3 23.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SAGA-Tad1 PF12767.7 CDI84821.1 - 0.7 9.6 24.2 0.91 9.2 24.2 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Endostatin PF06482.11 CDI84821.1 - 0.95 8.9 23.0 1.3 8.4 23.0 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF4746 PF15928.5 CDI84821.1 - 0.99 8.8 18.0 1.6 8.0 18.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Zip PF02535.22 CDI84821.1 - 1.1 8.4 11.9 1.4 8.0 11.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Suf PF05843.14 CDI84821.1 - 1.4 8.8 33.9 2.3 8.1 33.9 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Borrelia_P83 PF05262.11 CDI84821.1 - 1.5 7.2 30.9 1.7 7.1 30.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein MIIP PF15734.5 CDI84821.1 - 3 7.3 20.4 4 6.8 20.4 1.1 1 0 0 1 1 1 0 Migration and invasion-inhibitory DUF913 PF06025.12 CDI84821.1 - 3 6.7 15.4 4.2 6.2 15.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2076 PF09849.9 CDI84821.1 - 3.3 7.7 48.9 4.8 7.1 48.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) HCO3_cotransp PF00955.21 CDI84821.1 - 3.6 6.3 11.8 5.4 5.7 10.6 1.8 2 0 0 2 2 2 0 HCO3- transporter family GPCR_chapero_1 PF11904.8 CDI84821.1 - 4.6 6.6 17.6 6.6 6.1 17.6 1.2 1 0 0 1 1 1 0 GPCR-chaperone AUX_IAA PF02309.16 CDI84821.1 - 4.9 6.9 17.6 7.3 6.4 17.6 1.3 1 0 0 1 1 1 0 AUX/IAA family Asp-B-Hydro_N PF05279.11 CDI84821.1 - 4.9 7.1 24.2 7 6.6 24.2 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region LAP1C PF05609.12 CDI84821.1 - 5.3 6.0 26.2 7.5 5.5 26.2 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) F-protein PF00469.20 CDI84821.1 - 5.4 6.5 23.2 9.9 5.7 23.2 1.4 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef DUF2828 PF11443.8 CDI84821.1 - 7.4 4.5 22.9 12 3.8 22.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Exonuc_VII_L PF02601.15 CDI84821.1 - 9 5.8 29.8 12 5.3 29.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1635 PF07795.11 CDI84822.1 - 0.0017 18.3 2.5 0.0017 18.3 2.5 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1635) DUF4614 PF15391.6 CDI84822.1 - 0.045 13.7 12.4 0.085 12.9 12.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Apt1 PF10351.9 CDI84822.1 - 0.47 9.3 7.8 0.54 9.1 7.8 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain NST1 PF13945.6 CDI84822.1 - 1 9.4 8.4 1.9 8.6 8.4 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator SR-25 PF10500.9 CDI84822.1 - 1.2 8.7 20.9 1.9 8.0 20.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Secretin_N_2 PF07655.13 CDI84822.1 - 1.5 9.4 19.7 2 9.0 19.7 1.2 1 0 0 1 1 1 0 Secretin N-terminal domain Hid1 PF12722.7 CDI84822.1 - 2.6 6.1 5.1 3 5.9 5.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CDI84822.1 - 8.8 5.0 8.1 12 4.5 8.1 1.2 1 0 0 1 1 1 0 Presenilin CCDC106 PF15794.5 CDI84822.1 - 9.5 5.9 12.4 14 5.3 12.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SR-25 PF10500.9 CDI84823.1 - 9.9e-07 28.6 25.3 1.6e-06 28.0 25.3 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 CDI84823.1 - 0.012 13.7 36.9 0.017 13.3 36.9 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TFIIA PF03153.13 CDI84823.1 - 0.059 13.4 41.9 0.083 12.9 41.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 CDI84823.1 - 0.16 10.9 19.4 0.17 10.8 19.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Borrelia_P83 PF05262.11 CDI84823.1 - 0.23 9.9 14.4 0.21 10.0 14.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein MAP70 PF07058.11 CDI84823.1 - 0.3 9.8 14.9 0.35 9.6 14.9 1.0 1 0 0 1 1 1 0 Microtubule-associated protein 70 Peptidase_S64 PF08192.11 CDI84823.1 - 0.44 9.0 19.9 0.52 8.7 19.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 RR_TM4-6 PF06459.12 CDI84823.1 - 0.74 9.6 19.4 0.93 9.3 19.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SprA-related PF12118.8 CDI84823.1 - 0.9 8.6 38.4 1.3 8.1 38.4 1.2 1 0 0 1 1 1 0 SprA-related family CCSAP PF15748.5 CDI84823.1 - 1.2 9.3 32.6 1.6 8.8 32.6 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PAT1 PF09770.9 CDI84823.1 - 1.3 7.2 28.6 1.3 7.2 28.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 V_ATPase_I PF01496.19 CDI84823.1 - 1.3 6.8 14.0 1.4 6.7 14.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BAF1_ABF1 PF04684.13 CDI84823.1 - 1.4 7.9 18.3 1.7 7.6 18.3 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor PPP4R2 PF09184.11 CDI84823.1 - 1.4 8.4 15.8 1.6 8.2 15.8 1.1 1 0 0 1 1 1 0 PPP4R2 DUF572 PF04502.13 CDI84823.1 - 1.5 8.4 21.5 1.7 8.2 21.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) RAP1 PF07218.11 CDI84823.1 - 1.5 7.0 8.9 1.4 7.1 8.9 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SLC12 PF03522.15 CDI84823.1 - 2.4 7.1 18.9 2.9 6.8 18.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Activator_LAG-3 PF11498.8 CDI84823.1 - 2.6 6.9 47.3 3.4 6.5 47.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 PA26 PF04636.13 CDI84823.1 - 3.5 6.5 13.8 4.2 6.2 13.8 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SOBP PF15279.6 CDI84823.1 - 3.7 8.1 27.4 4.3 7.9 27.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4407 PF14362.6 CDI84823.1 - 4.6 6.5 17.5 5.5 6.2 17.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hamartin PF04388.12 CDI84823.1 - 6.9 5.2 24.4 8.1 5.0 24.4 1.0 1 0 0 1 1 1 0 Hamartin protein Raftlin PF15250.6 CDI84823.1 - 6.9 5.3 20.2 8.1 5.1 20.2 1.0 1 0 0 1 1 1 0 Raftlin Hid1 PF12722.7 CDI84823.1 - 9.1 4.3 28.7 11 4.1 28.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LAP1C PF05609.12 CDI84823.1 - 9.9 5.1 25.9 12 4.9 25.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) V_ATPase_I PF01496.19 CDI84824.1 - 0.17 9.8 27.6 0.18 9.7 27.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Hid1 PF12722.7 CDI84824.1 - 1.2 7.2 28.0 1.2 7.1 28.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Draxin PF15550.6 CDI84824.1 - 1.3 8.8 19.6 1.5 8.6 19.6 1.1 1 0 0 1 1 1 0 Draxin DUF572 PF04502.13 CDI84824.1 - 1.8 8.1 25.7 2.1 7.9 25.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) GREB1 PF15782.5 CDI84824.1 - 2 5.4 33.1 2.2 5.3 33.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hydin_ADK PF17213.3 CDI84824.1 - 3.6 7.8 26.6 4.7 7.4 26.6 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Lin-8 PF03353.15 CDI84824.1 - 5.3 6.5 36.1 6.7 6.2 36.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SAGA-Tad1 PF12767.7 CDI84824.1 - 5.5 6.6 25.7 6.2 6.5 25.7 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF4175 PF13779.6 CDI84824.1 - 6.5 4.5 67.7 7.6 4.3 67.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4551 PF15087.6 CDI84824.1 - 6.7 5.4 27.1 8.2 5.1 27.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Sin_N PF04801.13 CDI84824.1 - 8.3 5.5 41.5 8.7 5.4 41.5 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region TAF4 PF05236.14 CDI84824.1 - 8.4 6.0 29.6 12 5.5 29.6 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Dapper PF15268.6 CDI84824.1 - 8.8 5.0 35.1 9.6 4.9 35.1 1.0 1 0 0 1 1 1 0 Dapper Presenilin PF01080.17 CDI84824.1 - 9.8 4.8 37.6 12 4.6 37.6 1.1 1 0 0 1 1 1 0 Presenilin MRP-S26 PF14943.6 CDI84825.1 - 0.026 14.4 20.6 0.028 14.3 20.6 1.0 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 SR-25 PF10500.9 CDI84825.1 - 0.028 14.0 29.7 0.033 13.8 29.7 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ASD2 PF08687.11 CDI84825.1 - 2.3 7.7 24.6 2.4 7.6 24.6 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 DUF5427 PF10310.9 CDI84825.1 - 3.1 6.6 28.9 3.5 6.5 28.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) VIR_N PF15912.5 CDI84825.1 - 3.2 7.3 15.6 3.8 7.0 15.6 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal Rtf2 PF04641.12 CDI84825.1 - 4.2 6.7 21.3 4.6 6.5 21.3 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger SMYLE_N PF18615.1 CDI84825.1 - 9.9 5.6 21.6 11 5.5 21.6 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain SUIM_assoc PF16619.5 CDI84826.1 - 0.00011 22.2 3.5 0.00011 22.2 3.5 3.5 3 1 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI84826.1 - 0.0012 18.5 5.5 0.0012 18.5 5.5 2.6 2 1 0 2 2 2 1 Spt20 family SAM35 PF10806.8 CDI84826.1 - 0.032 14.5 1.6 0.066 13.5 1.6 1.5 1 0 0 1 1 1 0 SAM35, subunit of SAM coomplex Lin-8 PF03353.15 CDI84826.1 - 0.57 9.7 14.2 1.1 8.8 3.9 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist SARAF PF06682.12 CDI84826.1 - 1.2 8.7 19.8 0.017 14.8 2.7 2.2 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Pro_isomerase PF00160.21 CDI84828.1 - 2.3e-19 70.2 6.8 2.3e-19 70.2 6.8 2.2 2 1 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TCP PF03634.13 CDI84828.1 - 2.7e-05 24.8 15.7 0.011 16.3 6.6 2.3 2 0 0 2 2 2 2 TCP family transcription factor MecA PF05389.12 CDI84828.1 - 2.9e-05 23.8 13.1 0.0081 15.8 1.0 2.3 2 0 0 2 2 2 2 Negative regulator of genetic competence (MecA) DUF2722 PF10846.8 CDI84828.1 - 0.00027 20.0 20.2 0.00027 20.0 20.2 3.0 2 1 0 2 2 1 1 Protein of unknown function (DUF2722) DUF2076 PF09849.9 CDI84828.1 - 0.00084 19.5 11.3 0.00084 19.5 11.3 2.2 2 0 0 2 2 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Spt20 PF12090.8 CDI84828.1 - 0.0009 18.9 28.5 0.0009 18.9 28.5 2.9 2 1 0 2 2 1 1 Spt20 family Isy1 PF06246.12 CDI84828.1 - 0.0015 18.2 20.3 0.054 13.1 3.3 2.2 2 0 0 2 2 2 2 Isy1-like splicing family EOS1 PF12326.8 CDI84828.1 - 0.0017 18.3 10.1 0.2 11.6 0.6 2.2 2 0 0 2 2 2 2 N-glycosylation protein Eapp_C PF10238.9 CDI84828.1 - 0.0029 17.7 4.3 0.0029 17.7 4.3 2.3 2 0 0 2 2 2 1 E2F-associated phosphoprotein CCDC53 PF10152.9 CDI84828.1 - 0.0033 17.9 1.1 0.0033 17.9 1.1 2.4 2 1 0 2 2 1 1 Subunit CCDC53 of WASH complex DUF4834 PF16118.5 CDI84828.1 - 0.0043 18.0 6.3 0.0043 18.0 6.3 2.8 2 1 0 2 2 1 1 Domain of unknown function (DUF4834) eIF-3_zeta PF05091.12 CDI84828.1 - 0.0044 16.1 39.5 0.024 13.6 17.4 2.1 2 0 0 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AAA_11 PF13086.6 CDI84828.1 - 0.0059 16.4 21.6 0.04 13.7 2.6 2.1 2 0 0 2 2 2 2 AAA domain DUF2828 PF11443.8 CDI84828.1 - 0.0059 14.8 21.7 0.078 11.1 3.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF2828) MPM1 PF17234.2 CDI84828.1 - 0.0076 16.5 6.8 0.0076 16.5 6.8 2.2 2 0 0 2 2 1 1 Mitochondrial peculiar membrane protein 1 FmiP_Thoc5 PF09766.9 CDI84828.1 - 0.0099 15.2 35.0 0.084 12.1 9.3 2.2 2 0 0 2 2 2 2 Fms-interacting protein/Thoc5 SpoIIP PF07454.11 CDI84828.1 - 0.011 15.3 32.6 0.043 13.3 7.1 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Coilin_N PF15862.5 CDI84828.1 - 0.013 15.3 11.8 0.013 15.3 11.8 2.4 2 0 0 2 2 2 0 Coilin N-terminus PdaC PF13739.6 CDI84828.1 - 0.013 16.5 0.1 0.013 16.5 0.1 2.4 2 0 0 2 2 1 0 Deacetylase PdaC Peptidase_S49_N PF08496.10 CDI84828.1 - 0.026 14.6 3.2 0.026 14.6 3.2 2.2 2 0 0 2 2 1 0 Peptidase family S49 N-terminal DUF913 PF06025.12 CDI84828.1 - 0.027 13.4 15.3 0.37 9.7 1.7 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Gti1_Pac2 PF09729.9 CDI84828.1 - 0.031 14.4 22.0 0.091 12.8 2.5 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family PIP5K PF01504.18 CDI84828.1 - 0.038 13.2 24.2 0.028 13.6 2.1 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase CobT PF06213.12 CDI84828.1 - 0.04 13.3 43.4 0.33 10.3 12.7 2.3 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Baculo_PP31 PF05311.11 CDI84828.1 - 0.063 12.8 25.5 0.22 11.0 5.2 2.1 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) DUF4820 PF16091.5 CDI84828.1 - 0.074 12.4 21.6 0.066 12.6 2.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Peroxin-13_N PF04088.13 CDI84828.1 - 0.092 13.0 20.4 0.054 13.8 2.8 2.3 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Dynamin_N PF00350.23 CDI84828.1 - 0.1 12.6 13.5 0.13 12.3 0.5 2.3 2 0 0 2 2 2 0 Dynamin family CSG2 PF16965.5 CDI84828.1 - 0.14 11.1 17.3 0.084 11.8 1.8 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator DUF5385 PF17359.2 CDI84828.1 - 0.14 11.7 31.8 0.12 11.9 9.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5385) DUF2052 PF09747.9 CDI84828.1 - 0.17 12.0 30.9 0.38 10.9 7.8 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Afi1 PF07792.12 CDI84828.1 - 0.19 12.2 25.7 0.98 9.9 5.7 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Serinc PF03348.15 CDI84828.1 - 0.26 10.2 16.6 0.37 9.7 1.3 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) XRN_M PF17846.1 CDI84828.1 - 0.44 9.4 17.8 0.34 9.8 2.4 2.1 2 0 0 2 2 2 0 Xrn1 helical domain MMU163 PF17119.5 CDI84828.1 - 0.46 9.6 15.0 0.5 9.5 0.4 2.2 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis CLN3 PF02487.17 CDI84828.1 - 0.54 9.2 23.2 0.11 11.6 1.9 2.1 2 0 0 2 2 2 0 CLN3 protein ArsP_2 PF11449.8 CDI84828.1 - 0.61 9.2 6.2 4 6.5 0.6 2.2 2 0 0 2 2 2 0 Putative, 10TM heavy-metal exporter PRC2_HTH_1 PF18118.1 CDI84828.1 - 0.75 10.6 21.9 2.8 8.8 4.2 2.6 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Endostatin PF06482.11 CDI84828.1 - 0.85 9.0 29.0 0.075 12.5 3.9 2.1 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin UPF0560 PF10577.9 CDI84828.1 - 0.92 7.9 48.5 0.47 8.9 14.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 YABBY PF04690.13 CDI84828.1 - 1 9.9 24.3 3.5 8.2 5.5 2.3 2 0 0 2 2 2 0 YABBY protein Band_3_cyto PF07565.13 CDI84828.1 - 1 9.1 31.5 0.067 13.0 4.2 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Exonuc_VII_L PF02601.15 CDI84828.1 - 2.1 7.9 31.4 0.13 11.8 6.9 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit RIC3 PF15361.6 CDI84828.1 - 2.2 8.7 23.0 0.2 12.1 2.1 2.3 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 DUF4628 PF15429.6 CDI84828.1 - 2.2 7.9 30.0 0.048 13.3 4.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4628) DUF3807 PF12720.7 CDI84828.1 - 2.3 8.4 43.1 0.11 12.7 8.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) G0-G1_switch_2 PF15103.6 CDI84828.1 - 2.7 8.5 27.5 0.15 12.5 3.3 2.5 2 0 0 2 2 2 0 G0/G1 switch protein 2 MMM1 PF10296.9 CDI84828.1 - 3.8 6.5 20.2 1.5 7.8 2.8 2.3 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 AAR2 PF05282.11 CDI84828.1 - 3.8 6.8 20.3 0.35 10.2 0.5 2.2 2 0 0 2 2 2 0 AAR2 protein Sec62 PF03839.16 CDI84828.1 - 4 6.9 24.8 1.6 8.1 5.1 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 Anoctamin PF04547.12 CDI84828.1 - 4.3 6.1 12.0 1.9 7.2 2.4 2.2 2 0 0 2 2 2 0 Calcium-activated chloride channel Cellulose_synt PF03552.14 CDI84828.1 - 4.4 5.7 14.3 0.61 8.5 4.3 2.0 2 0 0 2 2 2 0 Cellulose synthase BORG_CEP PF14957.6 CDI84828.1 - 5.1 8.3 24.7 1.3 10.2 4.7 2.4 2 0 0 2 2 2 0 Cdc42 effector DUF1943 PF09172.11 CDI84828.1 - 5.1 6.2 16.4 2.9 7.0 4.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) DUF1980 PF09323.10 CDI84828.1 - 5.3 6.9 28.6 2 8.3 5.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Plasmodium_Vir PF05795.11 CDI84828.1 - 5.7 6.3 17.4 1.1 8.6 1.5 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein FAM60A PF15396.6 CDI84828.1 - 5.9 6.8 27.2 0.69 9.9 4.5 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Suf PF05843.14 CDI84828.1 - 6.1 6.7 48.9 0.042 13.8 13.7 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF4518 PF15008.6 CDI84828.1 - 6.9 5.8 37.9 0.023 13.9 8.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) GNAT_acetyltr_2 PF13718.6 CDI84828.1 - 7 6.0 25.5 0.19 11.1 3.9 2.2 2 0 0 2 2 2 0 GNAT acetyltransferase 2 DUF719 PF05334.13 CDI84828.1 - 7.1 6.8 29.2 0.4 10.8 5.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF719) V_ATPase_I PF01496.19 CDI84828.1 - 8.7 4.1 36.8 0.021 12.8 5.0 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family PcfK PF14058.6 CDI84828.1 - 9.7 6.5 39.4 1.3 9.3 15.5 2.4 3 0 0 3 3 2 0 PcfK-like protein zf-C3HC4_3 PF13920.6 CDI84829.1 - 7.9e-05 22.4 9.5 0.00013 21.8 9.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDI84829.1 - 0.05 13.5 10.4 0.09 12.7 10.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Cyt_bd_oxida_I PF01654.17 CDI84829.1 - 1.6 7.3 7.4 2.5 6.6 7.4 1.2 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit I EMP24_GP25L PF01105.24 CDI84830.1 - 1.7e-27 96.5 0.4 2.2e-27 96.2 0.4 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Methyltransf_16 PF10294.9 CDI84831.1 - 8.1e-08 32.2 0.0 0.0026 17.5 0.1 2.1 2 0 0 2 2 2 2 Lysine methyltransferase PrmA PF06325.13 CDI84831.1 - 1.5e-05 24.6 0.0 2.5e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 CDI84831.1 - 2.4e-05 24.3 0.0 4.5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDI84831.1 - 8.9e-05 22.1 0.0 0.00019 21.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CDI84831.1 - 0.00015 22.4 0.0 0.001 19.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI84831.1 - 0.0024 17.7 0.0 0.0059 16.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDI84831.1 - 0.013 16.2 0.0 0.68 10.6 0.0 2.6 3 0 0 3 3 3 0 Methyltransferase domain TehB PF03848.14 CDI84831.1 - 0.042 13.3 0.0 0.067 12.6 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Cons_hypoth95 PF03602.15 CDI84831.1 - 0.056 13.1 0.0 0.096 12.3 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 CDI84831.1 - 0.14 12.0 0.0 0.69 9.7 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Toxin_6 PF05453.12 CDI84831.1 - 0.25 11.8 1.5 0.5 10.9 1.5 1.4 1 0 0 1 1 1 0 BmTXKS1/BmP02 toxin family RskA PF10099.9 CDI84837.1 - 3.4e-08 34.0 11.7 4.6e-05 23.8 5.7 6.3 1 1 4 5 5 5 2 Anti-sigma-K factor rskA PAN_4 PF14295.6 CDI84837.1 - 9.4e-07 28.6 0.7 9.4e-07 28.6 0.7 2.0 2 0 0 2 2 2 1 PAN domain PAN_1 PF00024.26 CDI84837.1 - 2.9e-05 23.9 0.7 2.9e-05 23.9 0.7 2.3 2 0 0 2 2 2 1 PAN domain SseC PF04888.12 CDI84837.1 - 0.0055 16.4 7.9 0.0055 16.4 7.9 5.5 3 2 2 5 5 5 1 Secretion system effector C (SseC) like family Presenilin PF01080.17 CDI84838.1 - 0.016 14.0 46.1 0.016 14.0 46.1 1.0 1 0 0 1 1 1 0 Presenilin DUF5427 PF10310.9 CDI84838.1 - 0.54 9.2 43.4 0.67 8.9 43.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) CDC45 PF02724.14 CDI84838.1 - 0.73 8.1 36.8 0.82 7.9 36.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Apt1 PF10351.9 CDI84838.1 - 0.86 8.4 26.9 0.95 8.2 26.9 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain CCSAP PF15748.5 CDI84838.1 - 0.93 9.6 45.2 1 9.4 45.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 CDI84838.1 - 1.1 8.2 43.5 1.3 8.0 43.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 CDI84838.1 - 1.5 8.8 35.7 1.8 8.6 35.7 1.0 1 0 0 1 1 1 0 Protein Family FAM60A SRP-alpha_N PF04086.13 CDI84838.1 - 1.5 8.6 33.9 1.8 8.4 33.9 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF4045 PF13254.6 CDI84838.1 - 2.1 7.9 35.0 2.4 7.7 35.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) ALMT PF11744.8 CDI84838.1 - 2.3 7.0 33.8 2.7 6.7 33.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PAT1 PF09770.9 CDI84838.1 - 2.6 6.2 67.0 2.7 6.2 67.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF572 PF04502.13 CDI84838.1 - 3 7.4 34.1 4.5 6.8 34.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Peptidase_S64 PF08192.11 CDI84838.1 - 3.1 6.2 31.9 4.1 5.8 31.9 1.3 1 0 0 1 1 1 0 Peptidase family S64 RR_TM4-6 PF06459.12 CDI84838.1 - 3.3 7.5 44.7 4.3 7.1 44.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2052 PF09747.9 CDI84838.1 - 3.6 7.7 40.4 4.4 7.4 40.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Neur_chan_memb PF02932.16 CDI84838.1 - 3.6 7.6 33.4 5.9 6.9 33.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Raftlin PF15250.6 CDI84838.1 - 4.7 5.8 32.7 5.1 5.7 32.7 1.0 1 0 0 1 1 1 0 Raftlin MAP7 PF05672.11 CDI84838.1 - 5.9 6.6 65.3 7 6.3 65.3 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family Membralin PF09746.9 CDI84838.1 - 7.3 5.5 28.3 8.9 5.2 28.3 1.1 1 0 0 1 1 1 0 Tumour-associated protein Lin-8 PF03353.15 CDI84838.1 - 8 5.9 46.8 10 5.6 46.8 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RLL PF10036.9 CDI84839.1 - 2.3 8.0 12.6 1.2 8.9 2.9 2.3 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein EphA2_TM PF14575.6 CDI84839.1 - 2.5 9.0 14.6 21 6.1 0.4 3.6 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain RskA PF10099.9 CDI84840.1 - 0.00047 20.5 22.5 0.0044 17.3 17.8 23.5 1 1 10 13 13 13 2 Anti-sigma-K factor rskA MarC PF01914.17 CDI84840.1 - 0.039 13.3 0.0 0.039 13.3 0.0 4.1 5 1 0 5 5 5 0 MarC family integral membrane protein ETRAMP PF09716.10 CDI84840.1 - 0.27 11.3 0.0 0.27 11.3 0.0 6.1 6 1 0 6 6 6 0 Malarial early transcribed membrane protein (ETRAMP) RskA PF10099.9 CDI84841.1 - 0.024 14.9 5.4 0.03 14.6 5.4 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF5427 PF10310.9 CDI84841.1 - 0.088 11.7 18.5 0.098 11.6 18.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Ureide_permease PF07168.11 CDI84841.1 - 0.17 10.6 5.5 0.19 10.4 5.5 1.1 1 0 0 1 1 1 0 Ureide permease RR_TM4-6 PF06459.12 CDI84841.1 - 0.17 11.7 13.5 0.22 11.3 13.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SpoIIP PF07454.11 CDI84841.1 - 0.17 11.3 12.3 0.19 11.2 12.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) G0-G1_switch_2 PF15103.6 CDI84841.1 - 0.23 11.9 8.7 0.34 11.4 8.7 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 Peptidase_S49_N PF08496.10 CDI84841.1 - 0.23 11.5 9.1 0.31 11.1 9.1 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MCU PF04678.13 CDI84841.1 - 0.27 11.3 7.3 0.32 11.1 7.3 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter TFIIA PF03153.13 CDI84841.1 - 0.29 11.1 37.2 0.3 11.1 37.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4407 PF14362.6 CDI84841.1 - 0.37 10.1 11.0 0.37 10.1 11.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EMC3_TMCO1 PF01956.16 CDI84841.1 - 0.43 10.3 8.0 0.41 10.4 8.0 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like eIF-3_zeta PF05091.12 CDI84841.1 - 0.54 9.2 17.6 0.55 9.1 17.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4746 PF15928.5 CDI84841.1 - 0.56 9.6 5.9 0.47 9.8 5.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Peptidase_U57 PF05582.12 CDI84841.1 - 0.57 9.4 7.7 0.59 9.3 7.7 1.1 1 0 0 1 1 1 0 YabG peptidase U57 MTP18 PF10558.9 CDI84841.1 - 0.61 10.0 5.0 0.7 9.8 5.0 1.2 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) Insulin PF00049.18 CDI84841.1 - 0.67 11.0 9.7 1.1 10.3 9.7 1.3 1 0 0 1 1 1 0 Insulin/IGF/Relaxin family CobT PF06213.12 CDI84841.1 - 0.72 9.2 19.3 0.82 9.0 19.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Activator_LAG-3 PF11498.8 CDI84841.1 - 0.75 8.7 38.4 0.86 8.5 38.4 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Lin-8 PF03353.15 CDI84841.1 - 0.83 9.2 22.0 0.93 9.0 22.0 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Serinc PF03348.15 CDI84841.1 - 0.96 8.3 8.0 0.9 8.4 8.0 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) FHIPEP PF00771.20 CDI84841.1 - 1.1 7.7 5.7 0.98 7.8 5.7 1.1 1 0 0 1 1 1 0 FHIPEP family PepSY_TM PF03929.16 CDI84841.1 - 1.2 8.7 5.1 1.3 8.6 5.1 1.1 1 0 0 1 1 1 0 PepSY-associated TM region OATP PF03137.20 CDI84841.1 - 1.3 7.2 6.1 1.3 7.2 6.1 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Folate_carrier PF01770.18 CDI84841.1 - 1.3 7.7 7.8 1.4 7.5 7.8 1.1 1 0 0 1 1 1 0 Reduced folate carrier Band_3_cyto PF07565.13 CDI84841.1 - 1.6 8.5 14.6 2 8.2 14.6 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain OmpH PF03938.14 CDI84841.1 - 1.6 9.1 27.8 1.9 8.8 27.8 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF853 PF05872.12 CDI84841.1 - 1.6 7.2 9.0 1.6 7.3 9.0 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Sec62 PF03839.16 CDI84841.1 - 1.6 8.2 8.9 1.7 8.1 8.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 MAJIN PF15077.6 CDI84841.1 - 1.7 8.3 12.6 1.9 8.2 12.6 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein PMSI1 PF15322.6 CDI84841.1 - 1.8 7.9 14.5 2.1 7.7 14.5 1.0 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative V_ATPase_I PF01496.19 CDI84841.1 - 2.1 6.1 12.7 2.2 6.1 12.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Plasmodium_Vir PF05795.11 CDI84841.1 - 2.1 7.7 17.2 2.3 7.5 17.2 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF4175 PF13779.6 CDI84841.1 - 2.7 5.8 28.2 2.9 5.7 28.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DcuA_DcuB PF03605.14 CDI84841.1 - 2.7 6.8 4.1 3 6.7 4.1 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter FCP1_C PF09309.10 CDI84841.1 - 2.9 7.7 20.2 3.3 7.5 20.2 1.0 1 0 0 1 1 1 0 FCP1, C-terminal O-antigen_lig PF13425.6 CDI84841.1 - 3.1 6.5 3.1 3 6.5 3.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PAT1 PF09770.9 CDI84841.1 - 3.6 5.7 23.4 3.6 5.8 23.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CLN3 PF02487.17 CDI84841.1 - 4.6 6.2 10.7 4.6 6.2 10.7 1.1 1 0 0 1 1 1 0 CLN3 protein Dicty_REP PF05086.12 CDI84841.1 - 5.4 4.9 15.0 5.7 4.8 15.0 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Macoilin PF09726.9 CDI84841.1 - 5.6 5.4 21.9 6.3 5.2 21.9 1.0 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI84844.1 - 0.027 14.5 41.7 0.031 14.3 41.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AF-4 PF05110.13 CDI84844.1 - 0.038 12.1 38.7 0.056 11.5 38.7 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Macoilin PF09726.9 CDI84844.1 - 0.092 11.3 32.1 0.11 11.1 32.1 1.0 1 0 0 1 1 1 0 Macoilin family DUF2151 PF10221.9 CDI84844.1 - 0.28 9.7 18.0 0.32 9.6 18.0 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator CCDC24 PF15669.5 CDI84844.1 - 0.32 10.8 19.4 0.4 10.5 19.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family GAGA_bind PF06217.12 CDI84844.1 - 0.43 10.8 19.7 0.5 10.6 19.7 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family Paf1 PF03985.13 CDI84844.1 - 0.59 9.1 25.1 0.72 8.8 25.1 1.1 1 0 0 1 1 1 0 Paf1 RAP1 PF07218.11 CDI84844.1 - 0.63 8.3 15.5 0.72 8.1 15.5 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SLC12 PF03522.15 CDI84844.1 - 0.82 8.6 27.1 0.95 8.4 27.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 GREB1 PF15782.5 CDI84844.1 - 0.97 6.5 31.6 1.1 6.3 31.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Mem_trans PF03547.18 CDI84844.1 - 1 7.7 14.4 1.1 7.6 14.4 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF1387 PF07139.11 CDI84844.1 - 1 9.1 28.7 1.1 8.9 28.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF3523 PF12037.8 CDI84844.1 - 1.1 8.6 25.3 1.3 8.3 25.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) Presenilin PF01080.17 CDI84844.1 - 1.2 7.9 30.2 1.3 7.7 30.2 1.0 1 0 0 1 1 1 0 Presenilin NEMP PF10225.9 CDI84844.1 - 1.4 8.5 12.5 2 8.0 12.5 1.4 1 0 0 1 1 1 0 NEMP family DUF4770 PF15994.5 CDI84844.1 - 1.5 9.1 24.4 2.3 8.4 24.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) CDC45 PF02724.14 CDI84844.1 - 1.5 7.0 20.3 1.7 6.8 20.3 1.0 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 CDI84844.1 - 1.5 8.6 22.1 1.8 8.3 22.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI84844.1 - 1.6 6.9 31.6 1.8 6.7 31.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DDRGK PF09756.9 CDI84844.1 - 1.7 8.2 23.9 2 7.9 23.9 1.1 1 0 0 1 1 1 0 DDRGK domain Plasmodium_Vir PF05795.11 CDI84844.1 - 1.8 7.9 25.6 2.1 7.6 25.6 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TCRP1 PF14944.6 CDI84844.1 - 1.9 8.4 10.8 2.4 8.0 10.8 1.0 1 0 0 1 1 1 0 Tongue Cancer Chemotherapy Resistant Protein 1 MCM_bind PF09739.9 CDI84844.1 - 2.1 6.7 24.9 2.4 6.5 24.9 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor API5 PF05918.11 CDI84844.1 - 2.5 6.8 22.2 2.9 6.6 22.2 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Peptidase_S64 PF08192.11 CDI84844.1 - 2.7 6.4 31.2 3.2 6.1 31.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 SAPS PF04499.15 CDI84844.1 - 2.8 6.6 22.7 3.4 6.4 22.7 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Lin-8 PF03353.15 CDI84844.1 - 2.9 7.4 33.6 3.8 7.0 33.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Cwf_Cwc_15 PF04889.12 CDI84844.1 - 3.4 7.3 24.8 4.5 6.9 24.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Miga PF10265.9 CDI84844.1 - 3.5 6.5 28.0 4.2 6.2 28.0 1.0 1 0 0 1 1 1 0 Mitoguardin V_ATPase_I PF01496.19 CDI84844.1 - 3.6 5.4 19.8 4.7 5.0 19.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MPM1 PF17234.2 CDI84844.1 - 4.2 7.6 28.5 6.1 7.1 28.5 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Pkinase_fungal PF17667.1 CDI84844.1 - 4.3 6.0 17.3 5 5.8 17.3 1.1 1 0 0 1 1 1 0 Fungal protein kinase FAM60A PF15396.6 CDI84844.1 - 4.5 7.2 23.1 6.5 6.7 23.1 1.3 1 0 0 1 1 1 0 Protein Family FAM60A PepSY_TM PF03929.16 CDI84844.1 - 4.5 6.8 6.1 5.1 6.7 6.1 1.1 1 0 0 1 1 1 0 PepSY-associated TM region FliP PF00813.20 CDI84844.1 - 4.8 7.0 9.4 5.8 6.7 9.4 1.2 1 0 0 1 1 1 0 FliP family Dicty_REP PF05086.12 CDI84844.1 - 6.6 4.6 22.0 7.3 4.4 22.0 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4746 PF15928.5 CDI84844.1 - 7.9 5.8 13.0 10 5.4 13.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Neur_chan_memb PF02932.16 CDI84844.1 - 8.2 6.4 22.7 9.4 6.2 22.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region eIF-3_zeta PF05091.12 CDI84844.1 - 8.2 5.3 25.1 9.9 5.0 25.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MAT1 PF06391.13 CDI84844.1 - 8.5 6.1 29.5 11 5.7 29.5 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 XRN_M PF17846.1 CDI84844.1 - 8.6 5.2 18.3 10 5.0 18.3 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Yip1 PF04893.17 CDI84845.1 - 0.19 11.4 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Yip1 domain PNISR PF15996.5 CDI84845.1 - 0.85 9.9 37.0 1.2 9.4 37.0 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Tubulin_2 PF13809.6 CDI84845.1 - 1.8 7.7 16.0 2.5 7.2 16.0 1.2 1 0 0 1 1 1 0 Tubulin like SAGA-Tad1 PF12767.7 CDI84845.1 - 2.1 8.1 29.0 2.4 7.8 29.0 1.0 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit PAXIP1_C PF15364.6 CDI84845.1 - 6.3 7.1 29.1 4.1 7.7 15.0 2.1 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein SR-25 PF10500.9 CDI84847.1 - 0.0029 17.3 18.7 0.0034 17.0 18.7 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein MAP7 PF05672.11 CDI84847.1 - 0.0047 16.6 30.3 0.0055 16.4 30.3 1.0 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family Miga PF10265.9 CDI84847.1 - 0.013 14.5 16.8 0.014 14.4 16.8 1.0 1 0 0 1 1 1 0 Mitoguardin FHIPEP PF00771.20 CDI84847.1 - 0.021 13.3 10.3 0.027 13.0 10.3 1.2 1 0 0 1 1 1 0 FHIPEP family HemX PF04375.14 CDI84847.1 - 0.035 13.4 37.8 0.042 13.1 37.8 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase FCP1_C PF09309.10 CDI84847.1 - 0.043 13.7 18.6 0.05 13.5 18.6 1.2 1 0 0 1 1 1 0 FCP1, C-terminal eIF3_p135 PF12807.7 CDI84847.1 - 0.045 13.8 12.5 0.061 13.3 12.5 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 CobT PF06213.12 CDI84847.1 - 0.054 12.9 29.9 0.066 12.6 29.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SID-1_RNA_chan PF13965.6 CDI84847.1 - 0.078 11.4 9.6 0.09 11.2 9.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4603 PF15376.6 CDI84847.1 - 0.089 10.2 16.7 0.094 10.1 16.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) DUF4692 PF15763.5 CDI84847.1 - 0.1 13.0 12.8 0.14 12.6 12.8 1.3 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Macoilin PF09726.9 CDI84847.1 - 0.13 10.8 21.3 0.19 10.3 21.3 1.2 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI84847.1 - 0.14 12.1 53.0 0.16 11.9 53.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1645 PF07816.11 CDI84847.1 - 0.16 12.5 14.8 0.21 12.2 14.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Lin-8 PF03353.15 CDI84847.1 - 0.18 11.4 30.3 0.18 11.3 30.3 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DDRGK PF09756.9 CDI84847.1 - 0.2 11.2 26.2 0.23 11.1 26.2 1.1 1 0 0 1 1 1 0 DDRGK domain ADP_ribosyl_GH PF03747.14 CDI84847.1 - 0.21 11.3 3.9 0.24 11.1 3.9 1.1 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase Connexin PF00029.19 CDI84847.1 - 0.26 11.0 14.6 0.33 10.7 14.6 1.3 1 0 0 1 1 1 0 Connexin DUF2232 PF09991.9 CDI84847.1 - 0.28 10.3 8.3 0.33 10.1 8.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) CLN3 PF02487.17 CDI84847.1 - 0.29 10.1 15.5 0.33 9.9 15.5 1.1 1 0 0 1 1 1 0 CLN3 protein PTPRCAP PF15713.5 CDI84847.1 - 0.34 11.2 24.1 0.41 10.9 24.1 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF3807 PF12720.7 CDI84847.1 - 0.37 11.0 29.1 0.43 10.8 29.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) GAGA_bind PF06217.12 CDI84847.1 - 0.4 10.9 20.4 0.46 10.7 20.4 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family LTV PF04180.14 CDI84847.1 - 0.41 10.3 21.8 0.46 10.2 21.8 1.0 1 0 0 1 1 1 0 Low temperature viability protein ArsP_2 PF11449.8 CDI84847.1 - 0.46 9.6 2.7 0.59 9.3 2.7 1.2 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter eIF3_subunit PF08597.10 CDI84847.1 - 0.48 10.3 23.4 0.57 10.1 23.4 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF3824 PF12868.7 CDI84847.1 - 0.56 10.9 23.1 1.4 9.6 23.1 1.7 1 1 0 1 1 1 0 Domain of unknwon function (DUF3824) DUF2052 PF09747.9 CDI84847.1 - 0.59 10.2 23.7 0.68 10.0 23.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Apt1 PF10351.9 CDI84847.1 - 0.63 8.8 22.1 0.65 8.8 22.1 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ketoacyl-synt_2 PF13723.6 CDI84847.1 - 0.68 9.5 20.4 0.85 9.2 20.4 1.3 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain eIF-3_zeta PF05091.12 CDI84847.1 - 0.72 8.8 28.1 0.81 8.6 28.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FPN1 PF06963.12 CDI84847.1 - 0.73 8.3 6.6 0.89 8.0 6.6 1.3 1 0 0 1 1 1 0 Ferroportin1 (FPN1) CD20 PF04103.15 CDI84847.1 - 0.83 9.7 9.3 0.15 12.2 4.2 1.9 1 1 1 2 2 2 0 CD20-like family NARP1 PF12569.8 CDI84847.1 - 0.84 8.5 19.5 0.85 8.4 19.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 BORG_CEP PF14957.6 CDI84847.1 - 0.88 10.7 18.3 1.1 10.5 18.3 1.2 1 0 0 1 1 1 0 Cdc42 effector AMP-binding PF00501.28 CDI84847.1 - 0.89 8.1 6.4 0.91 8.0 6.4 1.1 1 0 0 1 1 1 0 AMP-binding enzyme SPX PF03105.19 CDI84847.1 - 0.92 9.4 23.9 0.96 9.3 23.9 1.0 1 0 0 1 1 1 0 SPX domain PA26 PF04636.13 CDI84847.1 - 0.93 8.3 16.4 1.2 8.0 16.4 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) GREB1 PF15782.5 CDI84847.1 - 1 6.4 29.3 1.1 6.3 29.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer GNAT_acetyltr_2 PF13718.6 CDI84847.1 - 1 8.7 12.8 1.2 8.4 12.8 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DUF3523 PF12037.8 CDI84847.1 - 1.1 8.6 35.7 1.3 8.4 35.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) FTO_NTD PF12933.7 CDI84847.1 - 1.1 8.5 15.9 1.2 8.3 15.9 1.2 1 0 0 1 1 1 0 FTO catalytic domain IHABP4_N PF16174.5 CDI84847.1 - 1.1 9.8 29.2 1.3 9.6 29.2 1.0 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Serinc PF03348.15 CDI84847.1 - 1.1 8.1 14.2 1.2 7.9 14.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RPN2_C PF18004.1 CDI84847.1 - 1.1 9.1 20.6 1.4 8.9 20.6 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CDC45 PF02724.14 CDI84847.1 - 1.3 7.2 22.4 1.5 7.1 22.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S15 PF02129.18 CDI84847.1 - 1.4 8.5 16.1 1.5 8.3 16.1 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Plasmodium_Vir PF05795.11 CDI84847.1 - 1.5 8.1 16.3 1.6 8.0 16.3 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein NEMP PF10225.9 CDI84847.1 - 1.5 8.4 10.7 1.9 8.1 10.7 1.2 1 0 0 1 1 1 0 NEMP family Paf1 PF03985.13 CDI84847.1 - 1.6 7.6 25.9 2.1 7.3 25.9 1.2 1 0 0 1 1 1 0 Paf1 CCSAP PF15748.5 CDI84847.1 - 1.6 8.8 28.2 2.1 8.4 28.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated FAM76 PF16046.5 CDI84847.1 - 1.7 7.9 26.2 2.1 7.6 26.2 1.0 1 0 0 1 1 1 0 FAM76 protein Cellulose_synt PF03552.14 CDI84847.1 - 1.8 7.0 11.6 1.9 6.9 11.6 1.0 1 0 0 1 1 1 0 Cellulose synthase MCD PF05292.11 CDI84847.1 - 1.8 8.0 11.3 2.3 7.7 11.3 1.2 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain Asp-B-Hydro_N PF05279.11 CDI84847.1 - 1.8 8.5 15.7 2 8.4 15.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region G6B PF15096.6 CDI84847.1 - 1.9 8.3 5.2 2.2 8.0 5.2 1.2 1 0 0 1 1 1 0 G6B family PMSI1 PF15322.6 CDI84847.1 - 2 7.8 21.3 2.2 7.7 21.3 1.1 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Peptidase_U57 PF05582.12 CDI84847.1 - 2 7.6 14.5 2.3 7.4 14.5 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Folate_carrier PF01770.18 CDI84847.1 - 2.1 7.0 12.3 2.5 6.7 12.3 1.2 1 0 0 1 1 1 0 Reduced folate carrier DUF1387 PF07139.11 CDI84847.1 - 2.2 8.0 25.7 2.5 7.8 25.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Ureide_permease PF07168.11 CDI84847.1 - 2.4 6.8 10.5 3.2 6.4 10.5 1.4 1 0 0 1 1 1 0 Ureide permease PPL5 PF18168.1 CDI84847.1 - 2.4 7.4 16.0 3.2 7.0 16.0 1.3 1 0 0 1 1 1 0 Prim-pol family 5 PAT1 PF09770.9 CDI84847.1 - 2.6 6.2 37.4 2.9 6.0 37.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S49_N PF08496.10 CDI84847.1 - 2.7 8.1 16.5 3.6 7.6 16.5 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Mcm10 PF09332.11 CDI84847.1 - 3 7.2 27.0 3.9 6.8 27.0 1.2 1 0 0 1 1 1 0 Mcm10 replication factor Tim54 PF11711.8 CDI84847.1 - 3.1 6.5 22.1 3.6 6.3 22.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF913 PF06025.12 CDI84847.1 - 3.1 6.7 15.3 3.8 6.4 15.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 CDI84847.1 - 3.2 7.5 25.9 3.7 7.3 25.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2072 PF09845.9 CDI84847.1 - 3.3 8.0 14.2 4.2 7.7 14.2 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein V_ATPase_I PF01496.19 CDI84847.1 - 3.8 5.3 22.1 4.1 5.2 22.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SLC12 PF03522.15 CDI84847.1 - 3.9 6.4 26.7 4.6 6.2 26.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4746 PF15928.5 CDI84847.1 - 4.2 6.7 15.5 4.9 6.5 15.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Presenilin PF01080.17 CDI84847.1 - 4.4 6.0 33.5 4.6 5.9 33.5 1.0 1 0 0 1 1 1 0 Presenilin AAR2 PF05282.11 CDI84847.1 - 4.4 6.6 19.7 5.3 6.3 19.7 1.1 1 0 0 1 1 1 0 AAR2 protein SUFU_C PF12470.8 CDI84847.1 - 4.5 7.3 17.4 5.6 7.0 17.4 1.1 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain Band_3_cyto PF07565.13 CDI84847.1 - 4.9 6.9 21.1 6.3 6.5 21.1 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Smac_DIABLO PF09057.10 CDI84847.1 - 5.8 6.2 23.5 6.1 6.1 23.5 1.2 1 0 0 1 1 1 0 Second Mitochondria-derived Activator of Caspases Peptidase_S64 PF08192.11 CDI84847.1 - 6.4 5.1 26.8 6.9 5.0 26.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 PAP1 PF08601.10 CDI84847.1 - 7.3 6.2 27.5 8.9 5.9 27.5 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 Mem_trans PF03547.18 CDI84847.1 - 8 4.7 13.2 9.2 4.5 13.2 1.1 1 0 0 1 1 1 0 Membrane transport protein EphA2_TM PF14575.6 CDI84847.1 - 8.2 7.4 20.6 1.2e+03 0.4 20.6 2.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Sec62 PF03839.16 CDI84847.1 - 8.5 5.8 17.7 11 5.5 17.7 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 UPF0560 PF10577.9 CDI84847.1 - 9.9 4.5 32.7 12 4.2 32.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Pkinase PF00069.25 CDI84848.1 - 2e-05 24.1 0.0 3.2e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF572 PF04502.13 CDI84849.1 - 0.079 12.6 18.6 0.092 12.4 18.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Dapper PF15268.6 CDI84849.1 - 0.18 10.6 24.7 0.19 10.6 24.7 1.0 1 0 0 1 1 1 0 Dapper V_ATPase_I PF01496.19 CDI84849.1 - 0.7 7.7 24.4 0.8 7.5 24.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PPP4R2 PF09184.11 CDI84849.1 - 1.1 8.8 12.5 1.2 8.6 12.5 1.1 1 0 0 1 1 1 0 PPP4R2 Hid1 PF12722.7 CDI84849.1 - 2.4 6.2 22.4 2.6 6.1 22.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1387 PF07139.11 CDI84849.1 - 5.7 6.6 23.7 7.8 6.1 23.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Piezo_RRas_bdg PF12166.8 CDI84849.1 - 6.3 6.0 17.5 7.6 5.7 17.5 1.0 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain DUF4776 PF16003.5 CDI84849.1 - 9.3 5.1 21.9 11 4.9 21.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) SOBP PF15279.6 CDI84849.1 - 10 6.7 34.3 14 6.2 34.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein SR-25 PF10500.9 CDI84851.1 - 0.0013 18.4 8.2 0.0013 18.4 8.2 6.9 2 1 2 5 5 5 2 Nuclear RNA-splicing-associated protein BRCT_3 PF18428.1 CDI84852.1 - 0.0027 17.7 0.0 2.3 8.3 0.0 3.6 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain BRCT PF00533.26 CDI84852.1 - 0.017 15.5 0.1 2 8.9 0.0 4.0 4 2 0 4 4 4 0 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CDI84852.1 - 0.18 12.2 0.0 3.8 8.0 0.0 2.9 3 0 0 3 3 3 0 BRCT domain, a BRCA1 C-terminus domain TIP49 PF06068.13 CDI84853.1 - 1.2e-156 521.3 0.1 1.5e-156 521.1 0.1 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CDI84853.1 - 1.6e-19 69.8 0.1 1.1e-18 67.2 0.0 2.3 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 CDI84853.1 - 6.5e-07 29.8 0.2 0.0054 17.2 0.1 2.6 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDI84853.1 - 4.6e-05 23.2 0.3 0.012 15.3 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDI84853.1 - 0.02 15.2 0.2 0.48 10.7 0.0 2.5 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 CDI84853.1 - 0.061 13.3 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 CDI84853.1 - 0.075 13.0 0.1 6.8 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 CDI84853.1 - 0.091 12.3 2.5 0.14 11.7 0.8 2.2 2 1 0 2 2 2 0 AAA domain Macoilin PF09726.9 CDI84854.1 - 0.00011 20.9 13.4 0.00011 20.9 13.4 3.2 3 0 0 3 3 3 2 Macoilin family EphA2_TM PF14575.6 CDI84854.1 - 0.061 14.2 12.4 0.12 13.3 1.0 4.1 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain Sec62 PF03839.16 CDI84854.1 - 2.2 7.7 4.5 29 4.1 0.1 3.0 3 0 0 3 3 3 0 Translocation protein Sec62 Mak16 PF04874.14 CDI84854.1 - 2.4 8.8 7.8 2 9.0 0.5 2.7 2 0 0 2 2 2 0 Mak16 protein C-terminal region TFB6 PF17110.5 CDI84854.1 - 4.9 6.9 6.4 5.6 6.7 0.3 2.6 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH PRP1_N PF06424.12 CDI84855.1 - 0.068 13.6 0.9 0.068 13.6 0.9 2.9 2 1 0 2 2 1 0 PRP1 splicing factor, N-terminal DUF2052 PF09747.9 CDI84855.1 - 0.089 12.9 13.2 0.23 11.6 5.5 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) FAM176 PF14851.6 CDI84855.1 - 0.22 11.2 12.2 0.089 12.5 0.8 2.5 2 0 0 2 2 2 0 FAM176 family BUD22 PF09073.10 CDI84855.1 - 0.23 10.8 17.4 0.3 10.4 9.7 2.1 2 0 0 2 2 2 0 BUD22 ALMT PF11744.8 CDI84855.1 - 0.62 8.8 12.2 1.5 7.5 1.1 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter SPX PF03105.19 CDI84855.1 - 1.2 9.0 24.9 2.3 8.0 24.9 1.4 1 1 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI84855.1 - 1.4 7.7 20.8 0.049 12.5 12.5 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain MscS_TM PF12794.7 CDI84855.1 - 2.1 7.1 5.3 3.7 6.3 5.3 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 GEMIN8 PF15348.6 CDI84855.1 - 2.6 8.3 18.2 4.4 7.5 4.7 2.2 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 RNA_pol_Rpc4 PF05132.14 CDI84855.1 - 2.8 8.4 7.1 5.2 7.5 1.0 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 CPSF100_C PF13299.6 CDI84855.1 - 4.6 7.4 9.3 8.6 6.5 0.9 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4820 PF16091.5 CDI84855.1 - 5 6.4 15.1 0.29 10.5 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF4614 PF15391.6 CDI84855.1 - 7.5 6.5 25.7 0.84 9.6 16.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) EIIBC-GUT_N PF03612.14 CDI84855.1 - 9.7 5.9 10.1 5.3 6.7 2.0 2.3 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus SapB_1 PF05184.15 CDI84856.1 - 0.048 13.7 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 Saposin-like type B, region 1 Cyc-maltodext_C PF10438.9 CDI84857.1 - 0.062 13.4 1.5 2.3 8.4 0.0 3.0 2 1 1 3 3 3 0 Cyclo-malto-dextrinase C-terminal domain Fcf1 PF04900.12 CDI84858.1 - 2.3e-09 37.5 6.7 0.00024 21.4 0.0 3.3 3 1 0 3 3 3 2 Fcf1 Spt20 PF12090.8 CDI84858.1 - 9.4 5.8 28.8 0.17 11.5 9.0 2.5 2 0 0 2 2 2 0 Spt20 family Lin-8 PF03353.15 CDI84859.1 - 0.0074 15.9 13.5 0.0074 15.9 13.5 1.7 2 0 0 2 2 2 1 Ras-mediated vulval-induction antagonist DUF572 PF04502.13 CDI84859.1 - 0.33 10.5 17.4 0.011 15.4 9.0 2.2 2 1 1 3 3 3 0 Family of unknown function (DUF572) Spt20 PF12090.8 CDI84859.1 - 0.44 10.1 63.7 0.25 10.9 24.6 3.4 3 0 0 3 3 3 0 Spt20 family LMBR1 PF04791.16 CDI84859.1 - 0.54 9.1 2.0 0.75 8.6 2.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein LIM_bind PF01803.16 CDI84859.1 - 0.74 9.3 14.0 0.63 9.5 3.5 2.6 2 0 0 2 2 2 0 LIM-domain binding protein SAPS PF04499.15 CDI84859.1 - 1.9 7.2 11.4 0.027 13.3 4.1 1.5 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF2828 PF11443.8 CDI84859.1 - 3.5 5.6 14.1 6.4 4.7 14.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SLC12 PF03522.15 CDI84859.1 - 5.8 5.8 17.3 11 4.9 17.3 1.4 1 0 0 1 1 1 0 Solute carrier family 12 SPG4 PF17325.2 CDI84859.1 - 9 7.4 12.9 4.4 8.4 1.0 3.5 4 0 0 4 4 4 0 Stationary phase protein 4 DUF3382 PF11862.8 CDI84860.1 - 0.0059 16.9 0.1 0.0079 16.4 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3382) Phage_sheath_1 PF04984.14 CDI84860.1 - 0.0061 16.4 2.1 0.0068 16.3 2.1 1.1 1 0 0 1 1 1 1 Phage tail sheath protein subtilisin-like domain TrbI PF03743.14 CDI84860.1 - 0.019 14.8 3.6 0.022 14.6 3.6 1.2 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein UPF0565 PF10561.9 CDI84860.1 - 0.022 14.0 3.6 0.026 13.7 3.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Peptidase_S8 PF00082.22 CDI84860.1 - 0.035 13.4 11.3 0.041 13.1 11.3 1.0 1 0 0 1 1 1 0 Subtilase family BAF1_ABF1 PF04684.13 CDI84860.1 - 0.043 12.9 5.9 0.044 12.9 5.9 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor AzlD PF05437.12 CDI84860.1 - 0.076 13.2 0.6 0.1 12.8 0.6 1.1 1 0 0 1 1 1 0 Branched-chain amino acid transport protein (AzlD) DUF3493 PF11998.8 CDI84860.1 - 0.11 12.7 2.6 0.15 12.3 2.6 1.2 1 0 0 1 1 1 0 Low psii accumulation1 / Rep27 Auxin_canalis PF05703.11 CDI84860.1 - 0.16 11.9 19.6 0.19 11.6 19.6 1.2 1 0 0 1 1 1 0 Auxin canalisation SR-25 PF10500.9 CDI84860.1 - 0.28 10.8 16.3 0.35 10.5 16.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4179 PF13786.6 CDI84860.1 - 0.43 11.1 6.4 1.1 9.7 6.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) SBE2 PF17076.5 CDI84860.1 - 0.53 8.4 6.7 0.57 8.3 6.7 1.0 1 0 0 1 1 1 0 SBE2, cell-wall formation TFIIA PF03153.13 CDI84860.1 - 1.9 8.4 9.6 2.2 8.2 9.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI84860.1 - 2.1 8.6 15.2 3.1 8.1 15.2 1.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA SseC PF04888.12 CDI84861.1 - 0.0012 18.6 3.5 0.0012 18.6 3.5 3.0 2 1 1 3 3 3 1 Secretion system effector C (SseC) like family MAP7 PF05672.11 CDI84861.1 - 4.3 7.0 72.5 5.1 6.8 8.0 2.3 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family DUF1168 PF06658.12 CDI84861.1 - 7.7 6.3 49.7 0.16 11.8 34.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) Glyco_transf_20 PF00982.21 CDI84862.1 - 1.8e-16 59.9 0.0 1.8e-16 59.9 0.0 3.0 2 1 1 3 3 3 1 Glycosyltransferase family 20 TFIIA PF03153.13 CDI84862.1 - 3.5e-05 24.0 33.0 5e-05 23.5 33.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 CDI84862.1 - 0.026 14.3 34.2 0.25 11.0 14.0 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Ndc1_Nup PF09531.10 CDI84862.1 - 0.035 12.8 6.8 0.041 12.6 6.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup BUD22 PF09073.10 CDI84862.1 - 0.069 12.5 29.7 0.025 14.0 10.2 2.3 2 0 0 2 2 2 0 BUD22 Herpes_pp85 PF04637.12 CDI84862.1 - 0.21 10.0 4.4 0.32 9.4 4.4 1.3 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Lin-8 PF03353.15 CDI84862.1 - 2.4 7.6 31.7 0.34 10.4 19.6 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist RAP1 PF07218.11 CDI84862.1 - 2.8 6.1 8.3 4 5.6 8.3 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SMYLE_N PF18615.1 CDI84863.1 - 0.49 9.9 24.5 0.56 9.7 24.5 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain FAM60A PF15396.6 CDI84863.1 - 1.1 9.3 32.1 1.2 9.1 32.1 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF4667 PF15700.5 CDI84863.1 - 7.5 6.6 36.7 9.7 6.2 36.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) SprA-related PF12118.8 CDI84865.1 - 0.00052 19.2 5.7 0.00052 19.2 5.7 7.3 5 3 2 7 7 7 1 SprA-related family RskA PF10099.9 CDI84866.1 - 0.009 16.3 17.5 0.009 16.3 17.5 3.1 2 1 1 3 3 2 1 Anti-sigma-K factor rskA LMBR1 PF04791.16 CDI84866.1 - 0.034 13.1 17.9 0.038 12.9 17.9 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein SPX PF03105.19 CDI84866.1 - 0.054 13.4 40.5 0.076 12.9 40.5 1.3 1 0 0 1 1 1 0 SPX domain GREB1 PF15782.5 CDI84866.1 - 0.19 8.8 42.2 0.27 8.3 42.2 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hamartin PF04388.12 CDI84866.1 - 0.21 10.2 32.1 0.27 9.9 32.1 1.2 1 0 0 1 1 1 0 Hamartin protein LAP1C PF05609.12 CDI84866.1 - 0.76 8.8 44.1 0.95 8.5 44.1 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC27 PF09507.10 CDI84866.1 - 0.93 8.8 41.2 1.2 8.4 41.2 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 OmpH PF03938.14 CDI84866.1 - 1.6 9.0 46.4 0.26 11.6 24.1 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) SR-25 PF10500.9 CDI84866.1 - 2.4 7.7 61.6 17 4.9 31.2 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4710 PF15828.5 CDI84866.1 - 3.7 7.7 6.6 0.81 9.8 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) CAC1F_C PF16885.5 CDI84866.1 - 4 7.0 32.2 5 6.7 32.2 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term AF-4 PF05110.13 CDI84866.1 - 5.1 5.0 53.2 7.5 4.5 53.2 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Miga PF10265.9 CDI84866.1 - 6.7 5.6 39.4 9.1 5.1 39.4 1.1 1 0 0 1 1 1 0 Mitoguardin ECM1 PF05782.11 CDI84866.1 - 6.9 5.5 34.1 9.2 5.1 34.1 1.2 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) Presenilin PF01080.17 CDI84867.1 - 0.35 9.6 58.2 0.065 12.0 33.3 2.1 2 0 0 2 2 2 0 Presenilin CRT10 PF08728.10 CDI84867.1 - 0.48 8.5 22.6 0.59 8.2 22.6 1.2 1 0 0 1 1 1 0 CRT10 DUF572 PF04502.13 CDI84867.1 - 1.7 8.2 48.3 2.3 7.8 48.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DALR_1 PF05746.15 CDI84868.1 - 1.2e-22 80.3 0.0 4.4e-08 33.3 0.0 3.4 3 1 1 4 4 4 3 DALR anticodon binding domain TFIIA PF03153.13 CDI84868.1 - 0.00062 19.9 15.6 0.00071 19.7 15.6 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI84868.1 - 0.001 19.2 4.8 0.0012 18.9 4.8 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) SprA-related PF12118.8 CDI84868.1 - 0.019 14.2 18.6 0.028 13.6 18.6 1.3 1 0 0 1 1 1 0 SprA-related family Coilin_N PF15862.5 CDI84868.1 - 0.06 13.1 7.2 0.11 12.3 7.2 1.4 1 0 0 1 1 1 0 Coilin N-terminus eIF-3_zeta PF05091.12 CDI84868.1 - 0.065 12.2 8.2 0.077 12.0 8.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Zip PF02535.22 CDI84868.1 - 0.066 12.4 4.1 0.086 12.0 4.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 CDI84868.1 - 0.11 12.5 4.4 0.15 12.1 4.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region V_ATPase_I PF01496.19 CDI84868.1 - 0.14 10.0 4.1 0.17 9.8 4.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SOBP PF15279.6 CDI84868.1 - 0.18 12.4 10.2 0.34 11.5 10.2 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein PPP4R2 PF09184.11 CDI84868.1 - 0.18 11.3 6.7 0.24 10.9 6.7 1.1 1 0 0 1 1 1 0 PPP4R2 SelP_N PF04592.14 CDI84868.1 - 0.28 10.6 10.5 0.38 10.1 10.5 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CDC45 PF02724.14 CDI84868.1 - 0.33 9.2 7.9 0.43 8.8 7.9 1.1 1 0 0 1 1 1 0 CDC45-like protein PA26 PF04636.13 CDI84868.1 - 0.35 9.8 6.3 0.45 9.4 6.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) AIF_C PF14721.6 CDI84868.1 - 0.47 10.8 5.9 0.88 9.9 5.9 1.5 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF3464 PF11947.8 CDI84868.1 - 0.53 10.0 4.8 0.89 9.3 4.8 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 TFB6 PF17110.5 CDI84868.1 - 0.56 9.9 4.9 13 5.5 3.7 2.8 3 0 0 3 3 3 0 Subunit 11 of the general transcription factor TFIIH NARP1 PF12569.8 CDI84868.1 - 0.78 8.6 6.6 1.1 8.1 6.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4175 PF13779.6 CDI84868.1 - 0.82 7.5 21.0 1 7.2 21.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Raftlin PF15250.6 CDI84868.1 - 0.94 8.2 11.8 1.3 7.7 11.8 1.1 1 0 0 1 1 1 0 Raftlin Presenilin PF01080.17 CDI84868.1 - 1.2 7.8 14.7 1.8 7.2 14.7 1.2 1 0 0 1 1 1 0 Presenilin Pex14_N PF04695.13 CDI84868.1 - 1.5 9.5 17.0 2.6 8.7 17.0 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MAJIN PF15077.6 CDI84868.1 - 3.2 7.5 7.1 4.5 7.0 7.1 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF2126 PF09899.9 CDI84868.1 - 3.4 5.6 5.8 4.4 5.3 5.8 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Band_3_cyto PF07565.13 CDI84868.1 - 3.9 7.2 9.1 5.5 6.7 9.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RR_TM4-6 PF06459.12 CDI84868.1 - 4.7 6.9 9.3 6.7 6.5 9.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4820 PF16091.5 CDI84868.1 - 4.9 6.4 10.1 8.8 5.6 10.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) PepSY_TM PF03929.16 CDI84868.1 - 6.5 6.3 5.3 4.3 6.9 3.3 1.6 2 0 0 2 2 2 0 PepSY-associated TM region CCDC53 PF10152.9 CDI84868.1 - 6.8 7.1 12.0 13 6.1 12.0 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Spt20 PF12090.8 CDI84868.1 - 8.2 6.0 34.7 12 5.5 34.5 1.4 1 1 0 1 1 1 0 Spt20 family Roughex PF06020.11 CDI84868.1 - 8.3 5.4 11.1 12 4.8 11.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein SpoIIP PF07454.11 CDI84869.1 - 0.054 12.9 18.3 0.058 12.8 18.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CDI84869.1 - 0.06 12.1 21.6 0.063 12.0 21.6 1.2 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI84869.1 - 0.067 13.2 45.8 0.11 12.5 45.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF913 PF06025.12 CDI84869.1 - 0.12 11.3 10.7 0.15 11.0 10.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Band_3_cyto PF07565.13 CDI84869.1 - 0.18 11.6 15.9 0.21 11.3 15.9 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SARAF PF06682.12 CDI84869.1 - 0.21 11.2 20.0 0.25 10.9 20.0 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4746 PF15928.5 CDI84869.1 - 0.23 10.8 12.3 0.25 10.7 12.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Cellulose_synt PF03552.14 CDI84869.1 - 0.28 9.6 7.1 0.32 9.4 7.1 1.0 1 0 0 1 1 1 0 Cellulose synthase Tim54 PF11711.8 CDI84869.1 - 0.28 9.9 15.4 0.34 9.6 15.4 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CDC45 PF02724.14 CDI84869.1 - 0.37 9.0 17.7 0.44 8.8 17.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4366 PF14283.6 CDI84869.1 - 0.49 10.4 7.9 0.76 9.8 7.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Sin_N PF04801.13 CDI84869.1 - 0.57 9.3 30.3 0.62 9.2 30.3 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region DDRGK PF09756.9 CDI84869.1 - 0.61 9.7 27.4 0.83 9.2 27.4 1.2 1 0 0 1 1 1 0 DDRGK domain Lin-8 PF03353.15 CDI84869.1 - 0.63 9.5 23.9 0.8 9.2 23.9 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Peptidase_S64 PF08192.11 CDI84869.1 - 0.84 8.0 15.7 0.94 7.9 15.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 Sec62 PF03839.16 CDI84869.1 - 0.85 9.1 15.4 1 8.8 15.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Connexin PF00029.19 CDI84869.1 - 0.89 9.3 17.2 1.3 8.7 17.2 1.2 1 0 0 1 1 1 0 Connexin NPR3 PF03666.13 CDI84869.1 - 0.94 8.2 18.4 1.1 8.0 18.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Het-C PF07217.11 CDI84869.1 - 1.4 7.4 9.5 1.7 7.1 9.5 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Pkinase_fungal PF17667.1 CDI84869.1 - 1.5 7.5 10.8 1.9 7.2 10.8 1.1 1 0 0 1 1 1 0 Fungal protein kinase PIG-S PF10510.9 CDI84869.1 - 2.3 7.0 19.6 2.8 6.7 19.6 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein DUF2151 PF10221.9 CDI84869.1 - 2.7 6.5 12.5 3 6.3 12.5 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator WDCP PF15390.6 CDI84869.1 - 2.9 6.2 12.5 3.1 6.1 12.5 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family SLC12 PF03522.15 CDI84869.1 - 3.6 6.5 21.7 4.2 6.3 21.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Otopetrin PF03189.13 CDI84869.1 - 3.7 6.3 9.5 3.7 6.3 9.5 1.2 1 0 0 1 1 1 0 Otopetrin CDK5_activator PF03261.15 CDI84869.1 - 3.9 6.9 14.4 4.4 6.8 14.4 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein HSP70 PF00012.20 CDI84869.1 - 4.8 5.2 15.1 6.1 4.9 15.1 1.1 1 0 0 1 1 1 0 Hsp70 protein Hamartin PF04388.12 CDI84869.1 - 5 5.7 20.2 5.5 5.5 20.2 1.0 1 0 0 1 1 1 0 Hamartin protein DUF3292 PF11696.8 CDI84869.1 - 5.3 5.3 13.0 6 5.1 13.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF4175 PF13779.6 CDI84869.1 - 5.7 4.7 49.3 6.5 4.5 49.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PAT1 PF09770.9 CDI84869.1 - 5.8 5.0 39.7 6.2 5.0 39.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Membralin PF09746.9 CDI84869.1 - 6.6 5.7 11.5 6.8 5.6 11.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein Pox_Ag35 PF03286.14 CDI84869.1 - 6.6 6.5 15.2 10 5.8 15.2 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Rtf2 PF04641.12 CDI84869.1 - 6.7 6.0 23.5 2.6 7.3 21.4 1.3 2 0 0 2 2 1 0 Rtf2 RING-finger DUF2370 PF10176.9 CDI84869.1 - 7 6.2 9.2 9.2 5.8 9.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) MDM10 PF12519.8 CDI84869.1 - 7.1 5.4 15.9 7.3 5.3 15.9 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Plasmodium_Vir PF05795.11 CDI84869.1 - 7.9 5.8 12.6 10 5.4 12.6 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SRP-alpha_N PF04086.13 CDI84869.1 - 8.3 6.2 26.9 10 6.0 26.9 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SID-1_RNA_chan PF13965.6 CDI84869.1 - 8.4 4.7 9.3 9.6 4.5 9.3 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GAS PF13851.6 CDI84870.1 - 3.3e-07 29.9 1.6 4.1e-07 29.6 1.2 1.4 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding DUF4455 PF14643.6 CDI84870.1 - 0.0015 17.3 0.8 0.002 16.9 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4455) DUF4482 PF14818.6 CDI84870.1 - 0.064 14.1 1.8 0.094 13.6 0.5 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4482) DUF2340 PF10209.9 CDI84870.1 - 0.064 13.7 0.1 0.13 12.7 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2340) DUF2205 PF10224.9 CDI84870.1 - 0.11 12.5 3.9 0.76 9.8 0.3 2.6 2 0 0 2 2 2 0 Short coiled-coil protein Prefoldin_2 PF01920.20 CDI84870.1 - 0.38 10.7 5.3 3.3 7.7 1.8 2.4 2 0 0 2 2 2 0 Prefoldin subunit Spt20 PF12090.8 CDI84871.1 - 0.00017 21.2 52.9 0.015 14.9 18.9 2.1 2 0 0 2 2 2 2 Spt20 family CobT PF06213.12 CDI84871.1 - 0.013 14.9 34.2 0.057 12.8 8.5 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF2052 PF09747.9 CDI84871.1 - 0.023 14.8 21.1 0.067 13.3 5.0 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Eapp_C PF10238.9 CDI84871.1 - 0.06 13.4 20.1 0.057 13.5 3.6 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF2722 PF10846.8 CDI84871.1 - 0.071 12.1 51.9 0.01 14.9 16.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) GEMIN8 PF15348.6 CDI84871.1 - 0.075 13.3 24.5 0.15 12.3 6.1 2.1 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 SpoIIP PF07454.11 CDI84871.1 - 0.081 12.4 21.5 0.28 10.6 4.2 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 CDI84871.1 - 0.13 12.0 16.1 0.074 12.8 1.9 2.1 2 0 0 2 2 2 0 Connexin CIAPIN1 PF05093.13 CDI84871.1 - 0.18 12.3 12.1 0.79 10.3 2.5 2.5 2 0 0 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DUF3807 PF12720.7 CDI84871.1 - 0.18 12.1 29.3 0.9 9.8 8.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) EPL1 PF10513.9 CDI84871.1 - 0.23 11.8 26.2 0.27 11.6 6.3 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like FHIPEP PF00771.20 CDI84871.1 - 0.25 9.8 13.3 0.23 9.9 2.7 2.1 2 0 0 2 2 2 0 FHIPEP family FAM176 PF14851.6 CDI84871.1 - 0.25 11.0 17.9 0.88 9.2 7.3 2.2 2 0 0 2 2 2 0 FAM176 family CPSF100_C PF13299.6 CDI84871.1 - 0.28 11.4 22.8 1.3 9.2 9.2 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Host_attach PF10116.9 CDI84871.1 - 0.41 11.2 17.9 0.25 11.9 1.7 2.4 2 0 0 2 2 2 0 Protein required for attachment to host cells AIF_C PF14721.6 CDI84871.1 - 0.45 10.9 18.8 0.31 11.4 3.0 2.4 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term MAT1 PF06391.13 CDI84871.1 - 0.52 10.1 21.4 0.066 13.0 4.6 2.1 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Paf1 PF03985.13 CDI84871.1 - 0.55 9.2 25.1 1.1 8.2 4.2 2.1 2 0 0 2 2 2 0 Paf1 Striatin PF08232.12 CDI84871.1 - 0.56 10.8 28.1 0.78 10.3 9.4 2.3 2 0 0 2 2 2 0 Striatin family RICTOR_N PF14664.6 CDI84871.1 - 0.64 9.0 13.9 0.041 12.9 2.9 2.1 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term Slu7 PF11708.8 CDI84871.1 - 0.68 9.6 21.6 0.83 9.4 2.2 2.1 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor BRF1 PF07741.13 CDI84871.1 - 0.69 10.3 20.4 0.58 10.5 4.5 2.4 2 0 0 2 2 2 0 Brf1-like TBP-binding domain CDC45 PF02724.14 CDI84871.1 - 0.71 8.1 21.3 0.66 8.2 4.2 2.0 2 0 0 2 2 2 0 CDC45-like protein eIF-3_zeta PF05091.12 CDI84871.1 - 0.71 8.8 27.1 0.93 8.4 8.0 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) THRAP3_BCLAF1 PF15440.6 CDI84871.1 - 1.1 8.2 37.8 1.3 7.9 37.8 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family NST1 PF13945.6 CDI84871.1 - 1.1 9.3 31.7 2.8 8.0 7.5 2.3 2 0 0 2 2 2 0 Salt tolerance down-regulator Roughex PF06020.11 CDI84871.1 - 1.2 8.1 25.8 0.28 10.3 4.5 2.1 2 0 0 2 2 2 0 Drosophila roughex protein Prothymosin PF03247.14 CDI84871.1 - 1.4 9.4 18.1 3 8.4 5.6 2.1 2 0 0 2 2 2 0 Prothymosin/parathymosin family Tim54 PF11711.8 CDI84871.1 - 1.5 7.5 21.6 1.2 7.8 5.7 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF5523 PF17661.1 CDI84871.1 - 1.6 8.4 21.9 0.28 10.8 4.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) DUF4175 PF13779.6 CDI84871.1 - 1.6 6.5 41.8 2 6.2 41.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ASD2 PF08687.11 CDI84871.1 - 1.7 8.2 26.9 0.28 10.7 8.6 2.1 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 FAM76 PF16046.5 CDI84871.1 - 1.7 7.9 27.3 1.7 7.9 7.4 2.0 2 0 0 2 2 2 0 FAM76 protein Pinin_SDK_memA PF04696.13 CDI84871.1 - 1.9 8.5 31.1 2.7 8.1 12.4 2.1 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region PBP1_TM PF14812.6 CDI84871.1 - 2.1 8.8 12.6 7.2 7.1 4.0 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal eIF_4EBP PF05456.11 CDI84871.1 - 2.1 8.3 15.7 4.3 7.3 4.2 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Mlh1_C PF16413.5 CDI84871.1 - 2.1 7.7 13.8 0.64 9.3 2.2 2.1 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus DUF2681 PF10883.8 CDI84871.1 - 2.4 8.6 29.1 4.6 7.7 10.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) ATAD4 PF15321.6 CDI84871.1 - 2.6 9.4 19.8 4.7 8.6 5.9 2.5 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Rad54_N PF08658.10 CDI84871.1 - 2.8 8.1 14.9 0.4 10.8 1.4 2.2 2 0 0 2 2 2 0 Rad54 N terminal DUF3408 PF11888.8 CDI84871.1 - 3 8.0 22.6 5.7 7.1 4.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) DUF913 PF06025.12 CDI84871.1 - 3.2 6.6 21.9 0.69 8.8 3.4 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) FlaG PF03646.15 CDI84871.1 - 3.6 7.8 31.8 0.74 10.0 10.5 2.5 2 0 0 2 2 2 0 FlaG protein PRP1_N PF06424.12 CDI84871.1 - 3.9 7.9 22.9 3.5 8.0 7.7 2.2 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal DUF702 PF05142.12 CDI84871.1 - 4 7.9 26.7 2.6 8.5 6.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Folliculin PF11704.8 CDI84871.1 - 4.4 7.1 22.9 0.79 9.6 6.7 2.3 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Bud13 PF09736.9 CDI84871.1 - 4.7 7.6 23.1 3.3 8.1 7.8 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex RSB_motif PF16294.5 CDI84871.1 - 4.8 7.5 25.4 0.98 9.7 6.1 2.2 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif TFB6 PF17110.5 CDI84871.1 - 4.8 6.9 15.2 2.1 8.1 1.8 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH OmpH PF03938.14 CDI84871.1 - 4.9 7.5 35.5 2.2 8.6 15.1 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DDRGK PF09756.9 CDI84871.1 - 5.2 6.6 25.1 0.93 9.1 6.9 2.1 2 0 0 2 2 2 0 DDRGK domain Spore_YhcN_YlaJ PF09580.10 CDI84871.1 - 5.4 7.1 20.8 5.7 7.0 6.5 2.2 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Baculo_PP31 PF05311.11 CDI84871.1 - 5.8 6.3 21.9 0.32 10.4 6.2 2.2 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) VIR_N PF15912.5 CDI84871.1 - 6.1 6.4 13.5 0.44 10.1 1.3 2.1 2 0 0 2 2 2 0 Virilizer, N-terminal TERB2 PF15101.6 CDI84871.1 - 6.1 6.8 33.5 3.5 7.6 14.3 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Coilin_N PF15862.5 CDI84871.1 - 6.8 6.5 32.2 4.7 7.0 9.4 2.4 2 0 0 2 2 2 0 Coilin N-terminus DUF2828 PF11443.8 CDI84871.1 - 6.8 4.6 20.8 0.23 9.5 3.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Apc15p PF05841.11 CDI84871.1 - 7.3 7.4 30.1 1.5 9.7 9.1 2.4 2 0 0 2 2 2 0 Apc15p protein F-protein PF00469.20 CDI84871.1 - 7.3 6.1 18.9 0.64 9.6 4.6 2.1 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef FGF-BP1 PF06473.12 CDI84871.1 - 7.4 6.3 25.9 2.3 8.0 5.5 2.1 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) Peptidase_S49_N PF08496.10 CDI84871.1 - 7.7 6.6 15.0 1 9.4 1.7 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal FYDLN_acid PF09538.10 CDI84871.1 - 8 7.2 18.4 0.6 10.8 0.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (FYDLN_acid) PPL5 PF18168.1 CDI84871.1 - 8 5.7 19.6 1 8.6 3.8 2.1 2 0 0 2 2 2 0 Prim-pol family 5 YABBY PF04690.13 CDI84871.1 - 8.2 7.0 18.2 6.4 7.3 3.3 2.3 2 0 0 2 2 2 0 YABBY protein CSG2 PF16965.5 CDI84871.1 - 8.6 5.2 15.8 0.52 9.2 3.0 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator UPF0560 PF10577.9 CDI84871.1 - 9.4 4.6 32.3 1.6 7.1 10.3 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 eIF3_subunit PF08597.10 CDI84871.1 - 9.7 6.0 24.3 4.5 7.1 4.3 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit O-antigen_lig PF13425.6 CDI84871.1 - 9.8 4.8 6.3 9.8 4.8 1.4 1.9 2 0 0 2 2 2 0 O-antigen ligase like membrane protein Rad51 PF08423.11 CDI84872.1 - 1.2e-05 24.7 5.6 0.44 9.8 0.2 3.8 3 1 0 3 3 3 3 Rad51 AAA_18 PF13238.6 CDI84872.1 - 0.00063 20.3 0.0 0.0019 18.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDI84872.1 - 0.016 15.3 1.4 0.016 15.3 1.4 2.8 2 1 1 3 3 3 0 AAA domain Baculo_VP39 PF04501.12 CDI84872.1 - 0.019 14.5 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Baculovirus major capsid protein VP39 CCSAP PF15748.5 CDI84872.1 - 0.056 13.6 17.2 0.091 12.9 17.2 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF2207 PF09972.9 CDI84872.1 - 0.31 9.8 1.9 0.61 8.8 0.0 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) AAA_22 PF13401.6 CDI84872.1 - 2.2 8.6 8.3 21 5.4 8.3 2.5 1 1 0 1 1 1 0 AAA domain SOBP PF15279.6 CDI84872.1 - 5.4 7.5 12.6 8.7 6.9 12.6 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein DUF2151 PF10221.9 CDI84873.1 - 0.0031 16.2 11.7 0.0034 16.0 11.7 1.2 1 0 0 1 1 1 1 Cell cycle and development regulator Drc1-Sld2 PF11719.8 CDI84873.1 - 0.65 9.5 38.3 0.77 9.2 38.3 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein SLC12 PF03522.15 CDI84873.1 - 5.1 6.0 16.2 6.6 5.6 16.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI84873.1 - 9.5 4.2 21.8 11 4.0 21.8 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TMA7 PF09072.10 CDI84874.1 - 4 8.3 5.4 6.8 7.6 0.2 3.5 2 1 1 3 3 3 0 Translation machinery associated TMA7 RAP1 PF07218.11 CDI84876.1 - 1.2 7.3 8.3 1.4 7.1 8.3 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) 2OG-FeII_Oxy_5 PF13759.6 CDI84879.1 - 0.98 9.9 0.1 0.98 9.9 0.1 3.5 3 0 0 3 3 3 0 Putative 2OG-Fe(II) oxygenase BSMAP PF12280.8 CDI84879.1 - 1.7 8.8 20.3 0.2 11.9 7.2 2.7 2 0 0 2 2 2 0 Brain specific membrane anchored protein RskA PF10099.9 CDI84880.1 - 0.58 10.4 58.7 0.055 13.8 22.8 3.3 1 1 1 3 3 3 0 Anti-sigma-K factor rskA DUF3246 PF11596.8 CDI84881.1 - 0.0026 17.2 2.2 0.004 16.6 2.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3246) PAT1 PF09770.9 CDI84882.1 - 0.032 12.5 51.5 0.041 12.2 51.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF572 PF04502.13 CDI84882.1 - 0.84 9.2 35.8 1 8.9 35.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SART-1 PF03343.13 CDI84882.1 - 1.1 7.8 48.0 1.3 7.5 48.0 1.0 1 0 0 1 1 1 0 SART-1 family LMBR1 PF04791.16 CDI84882.1 - 1.2 8.0 18.6 1.4 7.7 18.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein MRP-S31 PF15433.6 CDI84882.1 - 3.5 7.2 39.7 4.9 6.7 39.7 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 LAP1C PF05609.12 CDI84882.1 - 5.9 5.9 41.2 8.2 5.4 41.2 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CAC1F_C PF16885.5 CDI84882.1 - 8.1 6.0 29.0 10 5.7 29.0 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Arm PF00514.23 CDI84883.1 - 1.1e-05 25.2 44.4 0.023 14.7 1.7 8.3 8 0 0 8 8 8 5 Armadillo/beta-catenin-like repeat NOC3p PF07540.11 CDI84884.1 - 5.9e-12 45.9 0.2 5.9e-12 45.9 0.2 2.8 3 0 0 3 3 3 1 Nucleolar complex-associated protein SpoIIP PF07454.11 CDI84884.1 - 2.9 7.3 18.3 0.39 10.1 6.0 2.7 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Ndc1_Nup PF09531.10 CDI84884.1 - 3.7 6.1 0.0 3.7 6.1 0.0 3.4 2 1 1 3 3 3 0 Nucleoporin protein Ndc1-Nup DSPc PF00782.20 CDI84885.1 - 2e-07 30.9 0.2 9.3e-07 28.7 0.0 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDI84885.1 - 0.00068 19.3 0.1 0.0054 16.3 0.0 2.0 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DUF2722 PF10846.8 CDI84885.1 - 0.0013 17.8 9.9 0.0013 17.8 9.9 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI84885.1 - 0.0049 16.5 20.3 0.007 16.0 15.9 2.1 2 0 0 2 2 2 1 Spt20 family Glyco_trans_4_4 PF13579.6 CDI84885.1 - 0.02 15.3 1.5 0.02 15.3 1.5 2.5 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain Pex14_N PF04695.13 CDI84885.1 - 0.17 12.5 14.5 0.44 11.2 11.3 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region U1snRNP70_N PF12220.8 CDI84885.1 - 0.26 11.9 6.3 0.62 10.7 6.3 1.5 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal TMEM247 PF15444.6 CDI84885.1 - 0.31 11.1 3.2 0.71 9.9 3.2 1.6 1 0 0 1 1 1 0 Transmembrane protein 247 Presenilin PF01080.17 CDI84885.1 - 0.37 9.5 3.8 0.52 9.0 3.8 1.2 1 0 0 1 1 1 0 Presenilin Nucleoporin2 PF04096.14 CDI84885.1 - 0.6 10.2 4.9 3.9 7.6 2.8 2.2 2 0 0 2 2 2 0 Nucleoporin autopeptidase Suf PF05843.14 CDI84885.1 - 1.2 9.0 10.9 0.088 12.8 5.9 1.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF3464 PF11947.8 CDI84885.1 - 7 6.4 6.5 15 5.3 6.5 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Maf PF02545.14 CDI84886.1 - 2.4e-23 82.8 0.0 4.5e-10 39.6 0.0 2.9 2 1 0 2 2 2 2 Maf-like protein Efg1 PF10153.9 CDI84887.1 - 2.8e-08 34.1 4.2 2.8e-08 34.1 4.2 2.2 2 0 0 2 2 2 1 rRNA-processing protein Efg1 Coatomer_WDAD PF04053.14 CDI84888.1 - 5.1e-75 253.2 0.0 1.4e-74 251.8 0.0 1.7 1 1 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 CDI84888.1 - 3.4e-48 164.4 0.0 3.8e-30 105.0 0.0 2.1 1 1 1 2 2 2 2 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 CDI84888.1 - 3.4e-25 87.8 13.8 2.2e-07 31.5 0.5 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI84888.1 - 2.4e-12 47.0 0.0 4.1e-07 30.2 0.0 4.3 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain NRBF2_MIT PF17169.4 CDI84888.1 - 0.0096 16.1 0.5 0.028 14.7 0.5 1.7 1 0 0 1 1 1 1 MIT domain of nuclear receptor-binding factor 2 TPR_2 PF07719.17 CDI84888.1 - 0.054 13.6 5.6 4.5 7.6 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TCL1_MTCP1 PF01840.17 CDI84888.1 - 0.16 11.6 0.1 0.36 10.5 0.1 1.5 1 0 0 1 1 1 0 TCL1/MTCP1 family TPR_16 PF13432.6 CDI84888.1 - 0.88 10.3 6.6 34 5.2 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDI84888.1 - 2.1 8.9 8.1 4.1 8.0 2.3 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat AAA_2 PF07724.14 CDI84889.1 - 6.8e-48 163.0 0.0 9.4e-46 156.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 CDI84889.1 - 1.1e-22 80.9 0.0 1.1e-12 48.5 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CDI84889.1 - 1.6e-20 72.9 0.5 8.1e-20 70.7 0.5 2.4 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein Clp_N PF02861.20 CDI84889.1 - 1.1e-15 57.5 0.3 2.6e-08 33.9 0.1 3.4 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA_5 PF07728.14 CDI84889.1 - 7.6e-14 51.9 0.1 1.2e-07 31.8 0.0 3.3 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CDI84889.1 - 1.9e-07 31.0 0.0 0.00089 19.0 0.0 3.3 3 1 0 3 3 3 2 Sigma-54 interaction domain AAA_lid_9 PF17871.1 CDI84889.1 - 2e-07 30.9 1.2 2e-07 30.9 1.2 2.7 2 1 0 2 2 1 1 AAA lid domain AAA_22 PF13401.6 CDI84889.1 - 2.8e-06 27.6 1.4 0.043 14.1 0.0 4.1 3 1 0 4 4 3 2 AAA domain AAA_14 PF13173.6 CDI84889.1 - 5.5e-06 26.5 0.0 0.033 14.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CDI84889.1 - 6.2e-06 26.7 0.1 6.2e-06 26.7 0.1 5.2 4 3 2 6 6 5 1 AAA ATPase domain ATPase_2 PF01637.18 CDI84889.1 - 2.7e-05 24.2 0.2 3.2 7.6 0.1 3.8 3 0 0 3 3 3 2 ATPase domain predominantly from Archaea TniB PF05621.11 CDI84889.1 - 3.5e-05 23.3 0.4 0.0062 16.0 0.0 2.9 2 1 0 2 2 2 1 Bacterial TniB protein AAA_7 PF12775.7 CDI84889.1 - 0.00045 19.8 0.0 0.28 10.7 0.0 2.6 2 1 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 CDI84889.1 - 0.00046 20.7 0.3 3.3 8.3 0.0 3.6 3 0 0 3 3 3 2 AAA domain Zeta_toxin PF06414.12 CDI84889.1 - 0.0021 17.3 0.1 0.15 11.4 0.0 3.1 3 0 0 3 3 3 1 Zeta toxin RsgA_GTPase PF03193.16 CDI84889.1 - 0.0027 17.7 0.2 2.1 8.2 0.0 4.1 4 1 0 4 4 4 1 RsgA GTPase IstB_IS21 PF01695.17 CDI84889.1 - 0.0058 16.4 0.0 0.056 13.2 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 CDI84889.1 - 0.0094 16.3 0.0 3 8.3 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_3 PF07726.11 CDI84889.1 - 0.0096 15.8 0.0 0.65 9.9 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDI84889.1 - 0.0096 15.7 0.7 9.9 5.9 0.2 3.8 3 1 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain Torsin PF06309.11 CDI84889.1 - 0.013 15.6 0.0 0.21 11.7 0.0 2.6 3 0 0 3 3 2 0 Torsin DUF87 PF01935.17 CDI84889.1 - 0.019 15.0 2.9 0.54 10.3 0.0 3.5 3 1 0 3 3 3 0 Helicase HerA, central domain DUF815 PF05673.13 CDI84889.1 - 0.021 14.0 0.0 0.46 9.6 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 CDI84889.1 - 0.031 14.8 0.1 18 5.8 0.0 3.0 3 0 0 3 3 3 0 ABC transporter AAA_25 PF13481.6 CDI84889.1 - 0.034 13.7 3.4 0.18 11.4 0.0 3.6 3 1 0 3 3 3 0 AAA domain Roc PF08477.13 CDI84889.1 - 0.049 13.8 0.0 4.8 7.4 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 CDI84889.1 - 0.058 13.4 0.0 12 6.0 0.0 3.2 4 0 0 4 4 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 CDI84889.1 - 0.067 13.1 0.0 0.51 10.2 0.0 2.3 2 0 0 2 2 2 0 NACHT domain FlhC PF05280.11 CDI84889.1 - 0.14 11.8 0.0 0.4 10.4 0.0 1.7 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhC) Fmp27_WPPW PF10359.9 CDI84889.1 - 0.41 9.4 3.2 0.72 8.6 3.2 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain EcoEI_R_C PF08463.10 CDI84889.1 - 0.88 9.7 9.5 1 9.4 2.0 3.3 3 0 0 3 3 3 0 EcoEI R protein C-terminal MeaB PF03308.16 CDI84889.1 - 1 8.3 4.4 4 6.4 0.0 3.3 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_12 PF13087.6 CDI84890.1 - 4.1e-24 85.3 0.0 9.1e-16 58.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 CDI84890.1 - 3.5e-11 43.4 0.1 3.6e-06 27.0 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 CDI84890.1 - 2.2e-09 37.3 0.1 1.2e-08 34.9 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CDI84890.1 - 1.8e-06 28.3 0.0 4.3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDI84890.1 - 0.11 12.8 3.0 0.19 12.1 0.1 2.8 3 0 0 3 3 3 0 AAA ATPase domain Asn_synthase PF00733.21 CDI84893.1 - 1.1e-12 48.3 5.3 2.9e-07 30.5 1.0 3.2 2 1 0 2 2 2 2 Asparagine synthase Lectin_leg-like PF03388.13 CDI84894.1 - 4e-09 36.2 0.1 1.1e-08 34.7 0.1 1.7 1 1 0 1 1 1 1 Legume-like lectin family Got1 PF04178.12 CDI84895.1 - 5.9e-24 84.7 17.6 9.6e-24 84.0 17.6 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family Myb_Cef PF11831.8 CDI84896.1 - 8.4e-18 64.8 7.9 8.4e-18 64.8 7.9 4.3 4 1 0 4 4 4 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 CDI84896.1 - 4.1e-14 52.5 15.9 1.5e-11 44.3 1.1 3.8 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDI84896.1 - 7.2e-13 48.6 3.5 4.4e-12 46.1 2.5 3.0 3 1 1 4 4 4 2 Myb-like DNA-binding domain Rap1_C PF11626.8 CDI84896.1 - 0.32 11.1 7.4 0.41 10.8 0.1 3.5 3 0 0 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain TssC PF17541.2 CDI84896.1 - 6.9 5.4 6.5 0.27 10.0 0.4 1.7 2 0 0 2 2 2 0 Type VI secretion system, TssC, VipB Chorein_N PF12624.7 CDI84897.1 - 3e-10 40.2 0.0 7.3e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 TFIIA PF03153.13 CDI84898.1 - 0.002 18.2 18.1 0.002 18.2 18.1 2.4 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI84898.1 - 0.0025 17.5 7.3 0.0025 17.5 7.3 5.7 6 0 0 6 6 6 2 Nuclear RNA-splicing-associated protein Utp21 PF04192.12 CDI84898.1 - 0.0036 16.8 0.9 0.0036 16.8 0.9 2.8 2 1 0 2 2 2 1 Utp21 specific WD40 associated putative domain Spt20 PF12090.8 CDI84898.1 - 0.0055 16.4 8.2 0.018 14.7 8.2 1.9 1 0 0 1 1 1 1 Spt20 family baeRF_family10 PF18854.1 CDI84898.1 - 0.086 13.1 1.6 0.39 11.0 1.7 2.2 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 DUF1957 PF09210.11 CDI84898.1 - 0.13 12.7 1.3 0.47 10.9 1.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1957) LPG_synthase_TM PF03706.13 CDI84898.1 - 0.15 11.5 1.5 0.41 10.1 1.5 1.7 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region Draxin PF15550.6 CDI84898.1 - 0.52 10.1 9.6 1.2 9.0 9.6 1.5 1 0 0 1 1 1 0 Draxin SUIM_assoc PF16619.5 CDI84898.1 - 2.6 8.2 17.6 2.1 8.5 11.6 3.6 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 MOLO1 PF17175.4 CDI84899.1 - 1e-20 74.0 0.0 1.4e-20 73.6 0.0 1.1 1 0 0 1 1 1 1 Modulator of levamisole receptor-1 TPM_phosphatase PF04536.14 CDI84899.1 - 3e-05 24.2 0.0 0.0003 21.0 0.0 2.1 1 1 0 1 1 1 1 TPM domain UDPGT PF00201.18 CDI84899.1 - 0.12 11.2 0.0 0.17 10.6 0.0 1.3 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase MMR_HSR1 PF01926.23 CDI84900.1 - 3.9e-17 62.4 0.0 6.7e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDI84900.1 - 1.6e-07 31.0 0.0 1.9e-06 27.5 0.1 2.3 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CDI84900.1 - 1.9e-06 28.0 0.4 0.00031 20.8 0.2 2.2 2 0 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 CDI84900.1 - 2.1e-05 24.1 0.0 0.15 11.6 0.1 3.1 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CDI84900.1 - 2.9e-05 24.0 0.0 0.028 14.3 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 CDI84900.1 - 0.00022 20.6 0.1 0.00032 20.1 0.1 1.2 1 0 0 1 1 1 1 AIG1 family Roc PF08477.13 CDI84900.1 - 0.012 15.9 0.0 0.16 12.2 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 CDI84900.1 - 0.019 15.4 0.0 0.039 14.3 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain KH_2 PF07650.17 CDI84900.1 - 0.029 14.2 0.1 0.051 13.4 0.1 1.4 1 0 0 1 1 1 0 KH domain AAA_29 PF13555.6 CDI84900.1 - 0.031 14.0 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CDI84900.1 - 0.045 14.3 0.0 0.074 13.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 CDI84900.1 - 0.19 11.4 0.0 0.37 10.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain PTH2 PF01981.16 CDI84901.1 - 3.2e-18 66.1 0.3 3.8e-18 65.9 0.3 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 WD40 PF00400.32 CDI84902.1 - 2.8e-13 50.1 4.2 4.2e-05 24.2 0.1 5.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI84902.1 - 0.00027 21.2 0.0 0.043 14.1 0.0 3.0 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDI84902.1 - 0.16 10.9 0.0 0.3 10.0 0.0 1.4 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Telomere_Sde2_2 PF13297.6 CDI84903.1 - 7.9e-18 63.9 1.2 1.2e-17 63.3 0.2 1.9 2 0 0 2 2 2 1 Telomere stability C-terminal Sde2_N_Ubi PF13019.6 CDI84903.1 - 1.6e-11 44.3 1.8 1.6e-11 44.3 1.8 3.1 3 1 0 3 3 3 1 Silencing defective 2 N-terminal ubiquitin domain GREB1 PF15782.5 CDI84903.1 - 4.3 4.3 16.2 5.2 4.1 16.2 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Vta1 PF04652.16 CDI84903.1 - 5.5 7.0 11.3 1.8 8.6 7.8 1.9 2 0 0 2 2 2 0 Vta1 like PVL_ORF50 PF07768.11 CDI84903.1 - 6.5 7.1 6.8 1 9.7 0.4 2.5 2 1 0 2 2 2 0 PVL ORF-50-like family Hamartin PF04388.12 CDI84903.1 - 9 4.8 15.8 13 4.3 15.8 1.1 1 0 0 1 1 1 0 Hamartin protein SLBP_RNA_bind PF15247.6 CDI84904.1 - 4.7e-23 81.1 1.6 1.1e-22 79.9 1.6 1.7 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain Ribosomal_S8 PF00410.19 CDI84905.1 - 3.9e-21 75.3 0.0 4.6e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 Mito_carr PF00153.27 CDI84906.1 - 8.1e-43 144.3 5.7 8.2e-16 57.7 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein PAP2 PF01569.21 CDI84906.1 - 0.082 12.7 1.7 0.97 9.2 0.1 2.9 3 0 0 3 3 3 0 PAP2 superfamily EF-hand_7 PF13499.6 CDI84907.1 - 1e-10 41.9 1.9 2.4e-06 27.9 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI84907.1 - 1.4e-10 40.2 4.8 2.5e-07 30.1 0.1 4.8 5 1 1 6 6 6 1 EF-hand domain EF-hand_1 PF00036.32 CDI84907.1 - 1.8e-09 36.5 6.0 5.2e-06 25.6 0.1 5.2 6 0 0 6 6 6 2 EF hand EF-hand_8 PF13833.6 CDI84907.1 - 1.2e-06 28.3 3.0 0.0015 18.3 0.2 4.0 3 2 1 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.6 CDI84907.1 - 0.017 15.4 0.0 0.19 12.1 0.0 2.3 3 0 0 3 3 3 0 EF-hand domain DUF3008 PF11450.8 CDI84907.1 - 0.033 14.4 0.1 0.1 12.8 0.1 1.8 1 0 0 1 1 1 0 Protein of unknwon function (DUF3008) EF-hand_5 PF13202.6 CDI84907.1 - 0.41 10.2 2.9 7.3 6.3 0.1 3.4 3 0 0 3 3 3 0 EF hand cNMP_binding PF00027.29 CDI84908.1 - 3.5e-18 65.5 0.0 9.8e-18 64.0 0.0 1.8 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF1564 PF07600.11 CDI84908.1 - 0.26 11.0 0.5 1.3 8.7 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1564) DEAD PF00270.29 CDI84909.1 - 5.5e-42 143.5 0.0 1e-41 142.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI84909.1 - 4.5e-27 94.6 0.0 1e-26 93.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Cyt-b5 PF00173.28 CDI84910.1 - 1.5e-22 79.5 0.1 2e-22 79.1 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PspB PF06667.12 CDI84910.1 - 0.13 12.3 0.1 0.27 11.3 0.1 1.5 1 0 0 1 1 1 0 Phage shock protein B DnaJ PF00226.31 CDI84911.1 - 7e-15 54.9 1.0 1.3e-14 54.1 0.0 2.0 2 0 0 2 2 2 1 DnaJ domain Casc1_N PF15927.5 CDI84911.1 - 0.017 14.8 2.2 0.07 12.8 2.5 1.8 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus FmiP_Thoc5 PF09766.9 CDI84911.1 - 0.021 14.1 0.6 0.048 13.0 0.6 1.6 1 1 0 1 1 1 0 Fms-interacting protein/Thoc5 TPR_1 PF00515.28 CDI84912.1 - 2.9e-05 23.7 4.0 0.00019 21.1 2.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDI84912.1 - 8.5e-05 22.4 4.6 0.0018 18.2 0.8 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat Caldesmon PF02029.15 CDI84912.1 - 0.0011 17.8 24.0 0.0011 17.8 24.0 1.5 2 0 0 2 2 2 1 Caldesmon Presenilin PF01080.17 CDI84912.1 - 0.0023 16.8 31.5 0.0023 16.8 31.5 1.4 2 0 0 2 2 2 1 Presenilin CDC45 PF02724.14 CDI84912.1 - 0.0068 14.8 24.1 0.0088 14.4 24.1 1.2 1 0 0 1 1 1 1 CDC45-like protein SLC12 PF03522.15 CDI84912.1 - 0.007 15.4 31.5 0.0093 15.0 31.5 1.3 1 0 0 1 1 1 1 Solute carrier family 12 RskA PF10099.9 CDI84912.1 - 0.0081 16.5 12.7 0.0081 16.5 12.7 5.0 2 1 1 3 3 1 1 Anti-sigma-K factor rskA Dapper PF15268.6 CDI84912.1 - 0.011 14.7 27.7 0.013 14.4 27.7 1.2 1 0 0 1 1 1 0 Dapper NPR3 PF03666.13 CDI84912.1 - 0.043 12.6 26.6 0.067 12.0 26.6 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ALMT PF11744.8 CDI84912.1 - 0.072 11.9 22.8 0.094 11.5 22.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Hid1 PF12722.7 CDI84912.1 - 0.089 10.9 26.1 0.11 10.6 26.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Endostatin PF06482.11 CDI84912.1 - 0.2 11.1 25.4 0.36 10.2 25.4 1.4 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Hamartin PF04388.12 CDI84912.1 - 0.3 9.7 26.8 0.36 9.4 26.8 1.2 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 CDI84912.1 - 0.38 7.8 26.0 0.44 7.6 26.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer GPCR_chapero_1 PF11904.8 CDI84912.1 - 0.47 9.9 17.3 0.75 9.2 17.3 1.4 1 0 0 1 1 1 0 GPCR-chaperone DUF4776 PF16003.5 CDI84912.1 - 0.87 8.5 27.1 1.1 8.2 27.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) HCO3_cotransp PF00955.21 CDI84912.1 - 1.2 7.8 11.3 2 7.2 11.3 1.4 1 0 0 1 1 1 0 HCO3- transporter family RR_TM4-6 PF06459.12 CDI84912.1 - 1.3 8.8 37.3 0.043 13.6 30.9 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Smg8_Smg9 PF10220.9 CDI84912.1 - 1.3 7.2 32.6 1.9 6.7 32.6 1.1 1 0 0 1 1 1 0 Smg8_Smg9 DUF2151 PF10221.9 CDI84912.1 - 1.4 7.4 19.8 1.8 7.1 19.8 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Zip PF02535.22 CDI84912.1 - 1.6 7.8 18.6 2.8 7.0 18.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter LMBR1 PF04791.16 CDI84912.1 - 4.5 6.1 14.3 5.2 5.9 14.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Membralin PF09746.9 CDI84912.1 - 6.4 5.7 21.1 9.5 5.1 21.1 1.3 1 0 0 1 1 1 0 Tumour-associated protein Plasmodium_Vir PF05795.11 CDI84912.1 - 6.6 6.0 20.4 1.3 8.4 16.9 1.6 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DDRGK PF09756.9 CDI84912.1 - 6.9 6.2 50.7 0.12 11.9 43.1 1.8 2 0 0 2 2 2 0 DDRGK domain FAM60A PF15396.6 CDI84912.1 - 7.3 6.5 30.4 4.6 7.2 28.0 1.9 2 0 0 2 2 2 0 Protein Family FAM60A GAGA_bind PF06217.12 CDI84912.1 - 8.2 6.6 33.3 0.68 10.2 27.1 1.9 2 0 0 2 2 2 0 GAGA binding protein-like family SUIM_assoc PF16619.5 CDI84914.1 - 0.064 13.3 34.6 1 9.5 5.9 4.1 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 Secretin_N_2 PF07655.13 CDI84914.1 - 6.5 7.4 18.9 1.8 9.2 5.0 2.7 3 0 0 3 3 3 0 Secretin N-terminal domain RskA PF10099.9 CDI84916.1 - 6.3e-05 23.3 2.7 6.3e-05 23.3 2.7 12.4 5 4 3 8 8 8 2 Anti-sigma-K factor rskA ABC2_membrane_2 PF12679.7 CDI84916.1 - 0.12 11.6 0.0 0.12 11.6 0.0 6.5 5 1 0 5 5 5 0 ABC-2 family transporter protein Citrate_bind PF16114.5 CDI84917.1 - 9.2e-06 25.3 0.0 1.5e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding TLP-20 PF06088.11 CDI84917.1 - 1.2 9.0 13.9 4.8 7.0 0.7 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Pex14_N PF04695.13 CDI84917.1 - 3.3 8.4 14.2 31 5.2 10.2 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Utp14 PF04615.13 CDI84917.1 - 10 4.6 18.2 12 4.3 18.2 1.0 1 0 0 1 1 1 0 Utp14 protein TFIIA PF03153.13 CDI84920.1 - 1.6 8.7 66.9 1.8 8.5 25.0 2.4 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Afi1 PF07792.12 CDI84920.1 - 4.1 7.9 15.1 6.1 7.3 1.2 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Jak1_Phl PF17887.1 CDI84920.1 - 6.4 6.7 13.2 0.83 9.6 5.3 2.5 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain SPX PF03105.19 CDI84921.1 - 0.0002 21.4 7.8 0.0002 21.4 7.8 3.6 2 1 1 3 3 3 1 SPX domain AAA_23 PF13476.6 CDI84921.1 - 0.0063 17.0 3.0 0.0063 17.0 3.0 2.8 3 1 0 3 3 3 1 AAA domain Suf PF05843.14 CDI84921.1 - 0.0094 16.0 4.6 0.0094 16.0 4.6 4.4 4 1 1 5 5 5 1 Suppressor of forked protein (Suf) Mntp PF02659.15 CDI84922.1 - 0.15 11.8 0.1 0.6 9.9 0.1 2.0 1 0 0 1 1 1 0 Putative manganese efflux pump DUF1764 PF08576.10 CDI84924.1 - 0.45 11.4 15.3 0.52 11.2 15.3 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) SCAI PF12070.8 CDI84924.1 - 1.3 7.8 14.7 1.4 7.7 14.7 1.0 1 0 0 1 1 1 0 Protein SCAI SLC12 PF03522.15 CDI84925.1 - 1.5 7.8 33.9 1.5 7.8 33.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Asp-B-Hydro_N PF05279.11 CDI84925.1 - 1.7 8.7 25.7 1.8 8.6 25.7 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Membralin PF09746.9 CDI84925.1 - 4.1 6.3 21.0 4.5 6.2 21.0 1.3 1 0 0 1 1 1 0 Tumour-associated protein ALMT PF11744.8 CDI84925.1 - 4.8 5.9 26.2 5.6 5.7 26.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter XRN_M PF17846.1 CDI84925.1 - 6.9 5.5 23.6 6.7 5.5 23.6 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Nop14 PF04147.12 CDI84926.1 - 1.7e-12 46.5 19.0 5.1e-11 41.6 9.8 3.0 2 1 1 3 3 3 3 Nop14-like family SPT16 PF08644.11 CDI84926.1 - 0.24 11.6 4.8 0.94 9.6 0.9 2.3 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) Stm1_N PF09598.10 CDI84926.1 - 0.63 10.9 0.0 0.63 10.9 0.0 4.3 4 1 0 4 4 4 0 Stm1 TFIIA PF03153.13 CDI84926.1 - 3.9 7.4 29.4 8.2 6.3 29.4 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit START PF01852.19 CDI84927.1 - 5.2e-05 22.8 0.0 6.6e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 START domain PI3K_1B_p101 PF10486.9 CDI84928.1 - 0.0041 15.0 0.1 0.0048 14.8 0.1 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Sporozoite_P67 PF05642.11 CDI84928.1 - 0.0045 15.1 8.2 0.0062 14.7 8.2 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen Ribosomal_60s PF00428.19 CDI84928.1 - 0.013 16.1 18.5 0.013 16.1 18.5 4.5 1 1 1 3 3 1 0 60s Acidic ribosomal protein SDA1 PF05285.12 CDI84928.1 - 0.051 13.0 4.4 0.06 12.8 4.4 1.2 1 0 0 1 1 1 0 SDA1 YL1 PF05764.13 CDI84928.1 - 0.059 13.5 5.6 0.084 13.0 5.6 1.2 1 0 0 1 1 1 0 YL1 nuclear protein BSP_II PF05432.11 CDI84928.1 - 0.51 10.0 10.8 0.65 9.6 10.8 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) eIF3_subunit PF08597.10 CDI84928.1 - 0.51 10.2 17.0 0.84 9.5 17.0 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DNA_pol_phi PF04931.13 CDI84928.1 - 0.63 8.1 5.0 0.67 8.0 5.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi TFIIF_alpha PF05793.12 CDI84928.1 - 0.98 7.9 6.7 1.2 7.7 6.7 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FSA_C PF10479.9 CDI84928.1 - 1.1 7.3 11.6 0.5 8.4 9.5 1.4 1 1 0 1 1 1 0 Fragile site-associated protein C-terminus DUF4611 PF15387.6 CDI84928.1 - 1.3 9.2 8.2 0.51 10.6 5.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Nop14 PF04147.12 CDI84928.1 - 9 4.4 8.0 10 4.2 8.0 1.1 1 0 0 1 1 1 0 Nop14-like family RAP1 PF07218.11 CDI84928.1 - 9.4 4.4 9.5 11 4.1 9.5 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DcuA_DcuB PF03605.14 CDI84931.1 - 0.96 8.3 11.8 1.8 7.4 2.6 2.4 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Pinin_SDK_memA PF04696.13 CDI84931.1 - 4.7 7.3 57.7 6.8 6.8 19.0 2.3 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region RskA PF10099.9 CDI84932.1 - 0.00088 19.6 5.3 0.00088 19.6 5.3 3.0 1 1 1 2 2 2 1 Anti-sigma-K factor rskA K_channel_TID PF07941.11 CDI84932.1 - 0.0015 19.0 13.6 0.0015 19.0 13.6 5.6 4 1 0 4 4 1 1 Potassium channel Kv1.4 tandem inactivation domain Spt20 PF12090.8 CDI84932.1 - 0.0035 17.0 27.2 0.0035 17.0 27.2 3.2 2 1 1 3 3 3 1 Spt20 family PE_PPE_C PF12484.8 CDI84932.1 - 0.0046 17.8 7.9 0.0046 17.8 7.9 2.3 2 0 0 2 2 2 1 Polymorphic PE/PPE proteins C terminal LDB19 PF13002.7 CDI84932.1 - 0.054 13.2 0.9 0.088 12.5 0.9 1.3 1 0 0 1 1 1 0 Arrestin_N terminal like Peptidase_S64 PF08192.11 CDI84932.1 - 2.2 6.7 45.6 2.8 6.3 45.6 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF4746 PF15928.5 CDI84932.1 - 3.8 6.8 19.0 1 8.7 4.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) LAP1C PF05609.12 CDI84932.1 - 6.5 5.7 44.9 9.5 5.2 44.9 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Hamartin PF04388.12 CDI84932.1 - 7.2 5.1 33.9 9.4 4.8 33.9 1.2 1 0 0 1 1 1 0 Hamartin protein Peptidase_S15 PF02129.18 CDI84932.1 - 7.9 6.0 23.0 7.3 6.1 8.1 2.3 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF819 PF05684.12 CDI84932.1 - 8.5 5.3 6.1 0.45 9.5 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF819) PRCC PF10253.9 CDI84933.1 - 0.0046 17.8 27.1 0.0046 17.8 27.1 1.8 2 0 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting Nop53 PF07767.11 CDI84933.1 - 0.0066 15.9 12.4 0.0081 15.6 12.4 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Suf PF05843.14 CDI84933.1 - 0.007 16.4 19.9 0.0084 16.1 19.9 1.2 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) eIF-3_zeta PF05091.12 CDI84933.1 - 0.0099 14.9 13.3 0.011 14.8 13.3 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI84933.1 - 0.012 15.6 41.9 0.014 15.4 41.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NPR3 PF03666.13 CDI84933.1 - 0.027 13.3 18.6 0.038 12.8 18.6 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_S49_N PF08496.10 CDI84933.1 - 0.051 13.6 6.6 0.074 13.1 6.6 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal AAT PF03417.16 CDI84933.1 - 0.052 13.2 7.5 0.064 12.9 7.5 1.3 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase RR_TM4-6 PF06459.12 CDI84933.1 - 0.054 13.3 14.9 0.066 13.0 14.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PA26 PF04636.13 CDI84933.1 - 0.057 12.3 11.1 0.059 12.3 11.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4175 PF13779.6 CDI84933.1 - 0.057 11.3 26.3 0.067 11.1 26.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SLC12 PF03522.15 CDI84933.1 - 0.071 12.1 17.2 0.078 12.0 17.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 CDI84933.1 - 0.08 11.2 16.1 0.1 10.9 16.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Coilin_N PF15862.5 CDI84933.1 - 0.095 12.5 20.2 0.18 11.6 20.2 1.5 1 0 0 1 1 1 0 Coilin N-terminus PAT1 PF09770.9 CDI84933.1 - 0.13 10.5 23.4 0.13 10.5 23.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF737 PF05300.11 CDI84933.1 - 0.16 12.3 19.4 0.24 11.7 19.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF737) SpoIIP PF07454.11 CDI84933.1 - 0.18 11.2 13.8 0.26 10.7 13.8 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Raftlin PF15250.6 CDI84933.1 - 0.19 10.4 15.3 0.21 10.3 15.3 1.2 1 0 0 1 1 1 0 Raftlin DUF2126 PF09899.9 CDI84933.1 - 0.2 9.7 6.7 0.22 9.6 6.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Smg8_Smg9 PF10220.9 CDI84933.1 - 0.22 9.8 19.6 0.25 9.6 19.6 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Connexin PF00029.19 CDI84933.1 - 0.24 11.2 7.5 0.33 10.7 7.5 1.3 1 0 0 1 1 1 0 Connexin Tim54 PF11711.8 CDI84933.1 - 0.24 10.1 11.8 0.37 9.5 11.8 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ndc1_Nup PF09531.10 CDI84933.1 - 0.26 9.9 27.4 0.31 9.7 27.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SID-1_RNA_chan PF13965.6 CDI84933.1 - 0.28 9.6 7.3 0.3 9.4 7.3 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI84933.1 - 0.35 9.8 9.4 0.43 9.4 9.4 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF3292 PF11696.8 CDI84933.1 - 0.45 8.8 9.0 0.58 8.5 9.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) ALMT PF11744.8 CDI84933.1 - 0.51 9.1 13.6 0.52 9.1 13.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SAPS PF04499.15 CDI84933.1 - 0.62 8.8 14.2 0.74 8.5 14.2 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Cdh1_DBD_1 PF18196.1 CDI84933.1 - 0.64 10.3 4.9 1.1 9.5 4.9 1.5 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 DUF2828 PF11443.8 CDI84933.1 - 1.2 7.1 13.8 1.6 6.8 13.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Spem1 PF15670.5 CDI84933.1 - 1.5 8.3 17.2 2.2 7.8 17.2 1.3 1 0 0 1 1 1 0 Spermatid maturation protein 1 Utp14 PF04615.13 CDI84933.1 - 1.7 7.1 25.9 1.9 7.0 25.9 1.1 1 0 0 1 1 1 0 Utp14 protein LMBR1 PF04791.16 CDI84933.1 - 1.7 7.4 8.8 1.7 7.4 8.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1980 PF09323.10 CDI84933.1 - 1.7 8.5 12.7 3.1 7.7 12.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Paramyxo_ncap PF00973.19 CDI84933.1 - 1.9 7.3 16.3 2.2 7.1 16.3 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Spore_coat_CotO PF14153.6 CDI84933.1 - 2 8.3 20.0 3 7.7 20.0 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Ureide_permease PF07168.11 CDI84933.1 - 2.2 6.9 8.4 3.6 6.2 8.4 1.4 1 0 0 1 1 1 0 Ureide permease Hid1 PF12722.7 CDI84933.1 - 2.3 6.3 23.6 2.5 6.1 23.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LAP1C PF05609.12 CDI84933.1 - 2.3 7.2 24.2 2.8 6.9 24.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Velvet PF11754.8 CDI84933.1 - 4.2 7.2 33.9 11 5.9 33.9 1.7 1 1 0 1 1 1 0 Velvet factor Membralin PF09746.9 CDI84933.1 - 5.5 5.9 12.9 7.3 5.5 12.9 1.1 1 0 0 1 1 1 0 Tumour-associated protein Cellulose_synt PF03552.14 CDI84933.1 - 5.7 5.3 6.2 6.7 5.1 6.2 1.1 1 0 0 1 1 1 0 Cellulose synthase GREB1 PF15782.5 CDI84933.1 - 5.7 3.9 29.3 6.3 3.8 29.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CLN3 PF02487.17 CDI84933.1 - 6.1 5.8 12.2 9.1 5.2 12.2 1.4 1 0 0 1 1 1 0 CLN3 protein CSG2 PF16965.5 CDI84933.1 - 6.8 5.5 14.3 9.7 5.0 14.3 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator SOG2 PF10428.9 CDI84933.1 - 6.9 5.7 37.9 9.3 5.3 37.9 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Roughex PF06020.11 CDI84933.1 - 7.1 5.6 19.7 6.7 5.7 19.1 1.3 1 1 0 1 1 1 0 Drosophila roughex protein FancD2 PF14631.6 CDI84933.1 - 7.6 3.8 12.6 9 3.5 12.6 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Sec62 PF03839.16 CDI84933.1 - 7.7 6.0 12.7 11 5.4 12.7 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 O-antigen_lig PF13425.6 CDI84933.1 - 8.3 5.1 8.0 10 4.8 8.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PPP4R2 PF09184.11 CDI84933.1 - 8.5 5.9 20.4 11 5.6 20.4 1.1 1 0 0 1 1 1 0 PPP4R2 SPX PF03105.19 CDI84933.1 - 9 6.1 30.7 11 5.8 30.7 1.1 1 0 0 1 1 1 0 SPX domain Hamartin PF04388.12 CDI84933.1 - 9.1 4.8 32.5 10 4.6 32.5 1.0 1 0 0 1 1 1 0 Hamartin protein HCO3_cotransp PF00955.21 CDI84933.1 - 9.4 4.9 8.8 13 4.5 8.8 1.2 1 0 0 1 1 1 0 HCO3- transporter family Nrap_D5 PF17406.2 CDI84934.1 - 0.29 10.9 13.8 0.43 10.3 13.8 1.3 1 0 0 1 1 1 0 Nrap protein PAP/OAS1-like domain 5 FAM76 PF16046.5 CDI84934.1 - 0.45 9.8 18.6 0.56 9.5 18.6 1.1 1 0 0 1 1 1 0 FAM76 protein DUF2052 PF09747.9 CDI84934.1 - 0.64 10.1 22.6 0.8 9.8 22.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) NPR3 PF03666.13 CDI84934.1 - 0.93 8.2 14.7 1 8.1 14.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SLATT_1 PF18181.1 CDI84934.1 - 2.4 8.1 17.1 0.12 12.3 10.8 1.8 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 CDC45 PF02724.14 CDI84934.1 - 2.5 6.3 16.0 2.8 6.1 16.0 1.1 1 0 0 1 1 1 0 CDC45-like protein CFIA_Pcf11 PF11526.8 CDI84934.1 - 3 8.4 21.8 19 5.8 17.3 2.1 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 Thioredoxin_9 PF14595.6 CDI84934.1 - 3.3 7.5 12.8 4.6 7.0 12.8 1.3 1 1 0 1 1 1 0 Thioredoxin MAT1 PF06391.13 CDI84934.1 - 3.5 7.4 31.3 4.1 7.2 31.3 1.0 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 ASC PF00858.24 CDI84934.1 - 4.7 6.1 8.7 5.1 5.9 8.7 1.0 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel DUF2722 PF10846.8 CDI84935.1 - 0.1 11.5 5.4 0.1 11.5 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI84935.1 - 0.87 9.2 10.3 0.97 9.0 10.3 1.1 1 0 0 1 1 1 0 Spt20 family FAM199X PF15814.5 CDI84935.1 - 1.2 8.2 5.7 1.3 8.0 5.7 1.1 1 0 0 1 1 1 0 Protein family FAM199X TFIIA PF03153.13 CDI84935.1 - 5.6 6.9 14.2 7 6.5 14.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tic110 PF16940.5 CDI84935.1 - 7.2 5.0 15.9 8.2 4.8 15.9 1.0 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF3439 PF11921.8 CDI84936.1 - 0.0019 18.1 0.1 0.0019 18.1 0.1 2.7 2 2 1 4 4 4 1 Domain of unknown function (DUF3439) DUF2052 PF09747.9 CDI84938.1 - 0.0014 18.8 0.4 0.0014 18.8 0.4 3.5 2 1 1 3 3 3 1 Coiled-coil domain containing protein (DUF2052) Senescence_reg PF04520.13 CDI84938.1 - 0.0084 17.0 12.2 0.0084 17.0 12.2 2.8 1 1 0 2 2 2 1 Senescence regulator FAM176 PF14851.6 CDI84938.1 - 0.012 15.3 1.6 0.012 15.3 1.6 4.6 3 1 1 4 4 4 0 FAM176 family SDA1 PF05285.12 CDI84938.1 - 0.023 14.1 0.2 0.023 14.1 0.2 3.1 2 1 1 3 3 3 0 SDA1 Nha1_C PF08619.10 CDI84938.1 - 0.032 13.5 0.3 0.032 13.5 0.3 3.9 2 1 0 3 3 3 0 Alkali metal cation/H+ antiporter Nha1 C terminus Pterin_bind PF00809.22 CDI84938.1 - 0.037 13.7 0.1 0.037 13.7 0.1 2.3 3 0 0 3 3 3 0 Pterin binding enzyme DUF3446 PF11928.8 CDI84938.1 - 4.6 7.6 23.3 5.5 7.4 16.8 3.0 2 0 0 2 2 2 0 Early growth response N-terminal domain PRIMA1 PF16101.5 CDI84939.1 - 0.58 10.2 3.6 1.4 8.9 0.8 2.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Helicase_RecD PF05127.14 CDI84939.1 - 0.7 9.7 5.6 0.3 10.9 2.8 1.7 1 1 1 2 2 2 0 Helicase PPDK_N PF01326.19 CDI84941.1 - 1.4e-06 27.8 0.0 0.0027 17.0 0.0 3.7 2 1 0 2 2 2 2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain DUF4355 PF14265.6 CDI84941.1 - 0.0026 18.0 2.1 0.0026 18.0 2.1 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4355) Es2 PF09751.9 CDI84942.1 - 1.7e-06 28.1 42.6 0.0001 22.2 26.9 4.1 3 1 1 4 4 4 2 Nuclear protein Es2 RskA PF10099.9 CDI84942.1 - 0.0004 20.7 57.2 0.0013 19.1 0.0 4.8 1 1 2 3 3 3 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI84942.1 - 0.0072 16.0 15.0 0.0072 16.0 15.0 4.8 5 0 0 5 5 5 4 Nuclear RNA-splicing-associated protein DUF572 PF04502.13 CDI84943.1 - 0.17 11.5 28.3 0.2 11.2 28.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) FHIPEP PF00771.20 CDI84943.1 - 2.9 6.3 28.5 3.7 5.9 28.5 1.1 1 0 0 1 1 1 0 FHIPEP family RIFIN PF02009.16 CDI84945.1 - 1.7e-05 24.9 9.0 2e-05 24.6 9.0 1.0 1 0 0 1 1 1 1 Rifin LAP1C PF05609.12 CDI84945.1 - 0.029 13.5 9.8 0.034 13.3 9.8 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Zip PF02535.22 CDI84945.1 - 0.051 12.8 10.5 0.061 12.5 10.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2370 PF10176.9 CDI84945.1 - 0.1 12.2 8.0 0.15 11.7 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Tim54 PF11711.8 CDI84945.1 - 0.11 11.2 3.9 0.12 11.1 3.9 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NPR3 PF03666.13 CDI84945.1 - 0.12 11.1 19.5 0.13 11.0 19.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Apt1 PF10351.9 CDI84945.1 - 0.15 10.9 22.3 0.17 10.7 22.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF1180 PF06679.12 CDI84945.1 - 0.17 12.3 8.0 0.23 11.9 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) SID-1_RNA_chan PF13965.6 CDI84945.1 - 0.18 10.2 11.0 0.2 10.1 11.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DAG_kinase_N PF14513.6 CDI84945.1 - 0.86 9.8 11.3 1.1 9.5 11.3 1.1 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus BAF1_ABF1 PF04684.13 CDI84945.1 - 0.97 8.4 24.6 1.1 8.2 24.6 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FAM76 PF16046.5 CDI84945.1 - 1.4 8.2 17.0 1.6 8.0 17.0 1.0 1 0 0 1 1 1 0 FAM76 protein SLC12 PF03522.15 CDI84945.1 - 1.5 7.7 13.8 1.7 7.6 13.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 CDI84945.1 - 1.6 7.5 12.8 1.8 7.3 12.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3807 PF12720.7 CDI84945.1 - 2 8.7 14.8 2.5 8.3 14.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Endomucin PF07010.12 CDI84945.1 - 2.1 8.3 31.6 2.5 8.0 31.6 1.0 1 0 0 1 1 1 0 Endomucin Gti1_Pac2 PF09729.9 CDI84945.1 - 2.8 8.0 20.2 4 7.5 20.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family HCO3_cotransp PF00955.21 CDI84945.1 - 3.1 6.5 8.1 3.7 6.2 8.1 1.1 1 0 0 1 1 1 0 HCO3- transporter family Orf78 PF06024.12 CDI84945.1 - 3.7 7.9 26.9 9.9e+02 0.1 26.9 2.1 1 1 0 1 1 1 0 Orf78 (ac78) GREB1 PF15782.5 CDI84945.1 - 4.2 4.4 15.0 4.5 4.3 15.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Utp14 PF04615.13 CDI84945.1 - 4.4 5.8 18.5 5.1 5.5 18.5 1.0 1 0 0 1 1 1 0 Utp14 protein SMYLE_N PF18615.1 CDI84945.1 - 6.1 6.3 11.3 6.7 6.2 11.3 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Ureide_permease PF07168.11 CDI84945.1 - 6.4 5.4 9.8 7.6 5.2 9.8 1.0 1 0 0 1 1 1 0 Ureide permease Band_3_cyto PF07565.13 CDI84945.1 - 8.8 6.0 9.5 9.8 5.9 9.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TMEM154 PF15102.6 CDI84945.1 - 9 6.2 26.2 32 4.4 26.2 1.8 1 1 0 1 1 1 0 TMEM154 protein family SUIM_assoc PF16619.5 CDI84946.1 - 0.012 15.6 15.1 0.11 12.6 5.8 3.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 RSF PF14876.6 CDI84946.1 - 5.8 5.8 5.6 18 4.2 0.1 2.3 2 0 0 2 2 2 0 Respiratory growth transcriptional regulator Pex14_N PF04695.13 CDI84947.1 - 0.0084 16.8 0.5 0.0084 16.8 0.5 7.6 3 1 3 6 6 6 1 Peroxisomal membrane anchor protein (Pex14p) conserved region RskA PF10099.9 CDI84947.1 - 0.025 14.9 0.0 0.025 14.9 0.0 8.1 2 2 1 4 4 4 0 Anti-sigma-K factor rskA N6_N4_Mtase PF01555.18 CDI84950.1 - 1.9e-06 27.8 0.0 1.4 8.6 0.0 6.6 6 3 0 6 6 6 1 DNA methylase Peptidase_M50 PF02163.22 CDI84950.1 - 0.041 13.2 0.0 1.6 7.9 0.0 3.3 1 1 0 1 1 1 0 Peptidase family M50 PAP1 PF08601.10 CDI84950.1 - 1.3 8.6 0.0 1.3 8.6 0.0 13.4 5 4 7 12 12 12 0 Transcription factor PAP1 RskA PF10099.9 CDI84951.1 - 1.2e-05 25.7 2.6 0.013 15.8 0.0 2.0 1 1 1 2 2 2 1 Anti-sigma-K factor rskA CSG2 PF16965.5 CDI84951.1 - 0.0032 16.5 16.3 0.0037 16.3 16.3 1.0 1 0 0 1 1 1 1 Ceramide synthase regulator DUF3328 PF11807.8 CDI84951.1 - 0.0065 16.3 3.9 0.0072 16.1 3.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) PI3K_1B_p101 PF10486.9 CDI84951.1 - 0.032 12.0 20.8 0.035 11.9 20.8 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Peroxin-3 PF04882.12 CDI84951.1 - 0.12 11.3 26.8 0.14 11.2 26.8 1.0 1 0 0 1 1 1 0 Peroxin-3 Serinc PF03348.15 CDI84951.1 - 0.13 11.1 15.7 0.15 10.9 15.7 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Senescence_reg PF04520.13 CDI84951.1 - 0.74 10.6 19.2 1 10.2 19.2 1.2 1 0 0 1 1 1 0 Senescence regulator SLC12 PF03522.15 CDI84951.1 - 1.1 8.2 20.3 1.2 8.1 20.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 V_ATPase_I PF01496.19 CDI84951.1 - 1.1 7.1 19.2 1.4 6.8 19.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SID-1_RNA_chan PF13965.6 CDI84951.1 - 1.4 7.2 12.9 1.8 6.9 12.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Macoilin PF09726.9 CDI84951.1 - 2.7 6.5 26.7 3.2 6.2 26.7 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 CDI84951.1 - 2.9 6.6 26.4 4.1 6.1 26.4 1.2 1 0 0 1 1 1 0 Presenilin HSD3 PF15244.6 CDI84951.1 - 3.1 7.2 28.1 3.6 7.0 28.1 1.0 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 Apt1 PF10351.9 CDI84951.1 - 3.2 6.5 24.1 3.9 6.2 24.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF1180 PF06679.12 CDI84951.1 - 3.4 8.0 15.6 2.1 8.7 7.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) MID_MedPIWI PF18296.1 CDI84951.1 - 3.5 7.4 30.1 4.5 7.0 30.1 1.2 1 0 0 1 1 1 0 MID domain of medPIWI DUF4179 PF13786.6 CDI84951.1 - 3.9 8.0 6.8 0.15 12.5 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) SR-25 PF10500.9 CDI84951.1 - 3.9 7.0 46.8 50 3.4 46.8 2.2 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Zip PF02535.22 CDI84951.1 - 5.7 6.1 14.6 9.7 5.3 14.6 1.3 1 1 0 1 1 1 0 ZIP Zinc transporter DUF2126 PF09899.9 CDI84951.1 - 9.2 4.2 10.5 12 3.8 10.5 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Menin PF05053.13 CDI84951.1 - 9.4 4.5 16.2 11 4.2 16.2 1.1 1 0 0 1 1 1 0 Menin TPR_2 PF07719.17 CDI84952.1 - 1.5e-05 24.7 9.1 0.014 15.5 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI84952.1 - 2.7e-05 24.6 7.6 0.037 14.8 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDI84952.1 - 0.00028 20.5 0.2 0.51 10.1 0.0 3.1 2 1 1 3 3 3 2 TPR repeat TPR_1 PF00515.28 CDI84952.1 - 0.0017 18.1 2.0 1.6 8.7 0.0 4.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDI84952.1 - 0.021 15.3 3.8 1.6 9.3 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_20 PF14561.6 CDI84952.1 - 0.022 15.1 2.9 0.073 13.4 2.3 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDI84952.1 - 0.022 15.4 8.9 0.5 11.1 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDI84952.1 - 0.034 14.5 0.2 71 4.1 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat HEPN_AbiV PF18728.1 CDI84952.1 - 0.14 12.3 2.5 0.43 10.7 2.5 1.9 1 1 0 1 1 1 0 AbiV TPR_6 PF13174.6 CDI84952.1 - 0.29 11.9 4.3 16 6.4 0.2 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDI84952.1 - 1.7 9.0 8.0 0.15 12.4 0.5 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDI84952.1 - 1.8 9.0 5.4 76 3.9 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat AAA_lid_3 PF17862.1 CDI84953.1 - 1.5e-11 43.9 0.0 5.1e-11 42.2 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain DUF2339 PF10101.9 CDI84953.1 - 0.042 12.4 20.5 1.3 7.5 18.6 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2339) SUIM_assoc PF16619.5 CDI84953.1 - 2.8 8.1 0.0 2.8 8.1 0.0 11.1 4 4 2 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 Ndc80_HEC PF03801.13 CDI84954.1 - 1.1e-23 83.5 0.0 1.1e-23 83.5 0.0 3.2 3 1 0 3 3 3 1 HEC/Ndc80p family PhaC_N PF07167.13 CDI84954.1 - 4.8 6.8 11.5 0.95 9.1 0.7 2.5 1 1 1 2 2 2 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus Mcm10 PF09332.11 CDI84955.1 - 3.3e-13 49.8 9.5 3.3e-13 49.8 9.5 3.2 2 1 0 2 2 2 1 Mcm10 replication factor zf-primase PF09329.11 CDI84955.1 - 7.3e-09 35.3 0.3 2.1e-08 33.8 0.3 1.8 1 0 0 1 1 1 1 Primase zinc finger DZR PF12773.7 CDI84955.1 - 2 8.5 8.1 30 4.7 8.1 2.6 1 1 0 1 1 1 0 Double zinc ribbon Nucleos_tra2_N PF01773.20 CDI84956.1 - 0.11 13.1 0.2 0.7 10.5 0.0 2.1 2 0 0 2 2 2 0 Na+ dependent nucleoside transporter N-terminus YihI PF04220.12 CDI84958.1 - 0.013 15.3 11.2 0.017 14.9 11.2 1.1 1 0 0 1 1 1 0 Der GTPase activator (YihI) ESM4 PF15952.5 CDI84958.1 - 0.017 15.6 13.3 0.022 15.2 13.3 1.4 1 0 0 1 1 1 0 Enhancer of split M4 family RasGAP PF00616.19 CDI84958.1 - 0.019 14.7 10.0 0.026 14.2 10.0 1.2 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase DUF5336 PF17270.2 CDI84958.1 - 0.025 14.2 2.3 0.037 13.7 2.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5336) Membralin PF09746.9 CDI84958.1 - 0.036 13.1 3.2 0.039 13.0 3.2 1.1 1 0 0 1 1 1 0 Tumour-associated protein Med15 PF09606.10 CDI84958.1 - 0.089 11.5 24.6 0.097 11.4 24.6 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI84958.1 - 0.094 12.7 24.7 0.1 12.5 24.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Dynamin_N PF00350.23 CDI84958.1 - 0.14 12.3 2.2 0.14 12.2 2.2 1.2 1 0 0 1 1 1 0 Dynamin family TMEM51 PF15345.6 CDI84958.1 - 0.21 11.4 8.3 0.25 11.1 8.3 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 PIG-S PF10510.9 CDI84958.1 - 0.3 9.9 8.8 0.29 9.9 8.8 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein PilM PF07419.12 CDI84958.1 - 0.39 10.9 3.8 0.68 10.1 3.8 1.5 1 0 0 1 1 1 0 PilM GNAT_acetyltr_2 PF13718.6 CDI84958.1 - 0.47 9.8 8.3 0.61 9.5 8.3 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 ALMT PF11744.8 CDI84958.1 - 0.57 8.9 3.9 0.6 8.9 3.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Suf PF05843.14 CDI84958.1 - 0.66 9.9 10.2 0.78 9.7 10.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hydin_ADK PF17213.3 CDI84958.1 - 0.7 10.1 6.4 1 9.6 6.4 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Topoisom_I_N PF02919.15 CDI84958.1 - 0.72 9.3 7.5 0.98 8.9 7.5 1.1 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Spt20 PF12090.8 CDI84958.1 - 0.75 9.4 31.1 1.1 8.8 31.1 1.3 1 0 0 1 1 1 0 Spt20 family EIIBC-GUT_N PF03612.14 CDI84958.1 - 1 9.1 5.6 1.2 8.8 5.6 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus MMR1 PF08505.10 CDI84958.1 - 1.2 9.4 10.4 1.4 9.1 10.4 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein PAT1 PF09770.9 CDI84958.1 - 1.4 7.1 17.8 1.6 6.9 17.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CemA PF03040.14 CDI84958.1 - 1.9 8.4 6.9 2 8.3 6.9 1.1 1 0 0 1 1 1 0 CemA family Presenilin PF01080.17 CDI84958.1 - 2.1 7.0 7.6 2.5 6.8 7.6 1.1 1 0 0 1 1 1 0 Presenilin DUF4175 PF13779.6 CDI84958.1 - 2.4 6.0 24.4 2.7 5.8 24.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) FTZ PF03867.14 CDI84958.1 - 2.6 7.5 8.5 3.8 7.0 8.5 1.3 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region TERB2 PF15101.6 CDI84958.1 - 2.8 7.9 12.1 3.3 7.7 12.1 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4199 PF13858.6 CDI84958.1 - 3.3 8.1 5.3 5.2 7.4 5.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Neur_chan_memb PF02932.16 CDI84958.1 - 3.8 7.5 6.2 4.5 7.2 6.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CLN3 PF02487.17 CDI84958.1 - 4 6.4 5.9 4.8 6.1 5.9 1.1 1 0 0 1 1 1 0 CLN3 protein DUF3464 PF11947.8 CDI84958.1 - 4.1 7.1 9.1 12 5.6 8.1 2.0 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Exonuc_VII_L PF02601.15 CDI84958.1 - 7.9 5.9 16.3 9.6 5.7 16.3 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF572 PF04502.13 CDI84960.1 - 0.81 9.3 64.0 2.1 7.9 32.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) TFIIF_alpha PF05793.12 CDI84960.1 - 5.1 5.6 56.1 0.11 11.1 34.1 2.6 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CCSAP PF15748.5 CDI84962.1 - 0.00023 21.4 25.0 0.00025 21.3 25.0 1.2 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated CDC45 PF02724.14 CDI84962.1 - 0.0037 15.6 19.7 0.0049 15.2 19.7 1.1 1 0 0 1 1 1 1 CDC45-like protein DUF2722 PF10846.8 CDI84962.1 - 0.0054 15.7 8.7 0.0054 15.7 8.7 3.1 2 1 1 3 3 2 1 Protein of unknown function (DUF2722) Sin_N PF04801.13 CDI84962.1 - 0.0067 15.7 40.9 0.0075 15.5 40.9 1.1 1 0 0 1 1 1 1 Sin-like protein conserved region 7tm_3 PF00003.22 CDI84962.1 - 0.027 14.2 0.1 0.034 13.9 0.1 1.3 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR SLC12 PF03522.15 CDI84962.1 - 0.029 13.4 27.8 0.033 13.2 27.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4534 PF15049.6 CDI84962.1 - 0.029 14.1 1.1 0.029 14.1 1.1 2.7 1 1 1 2 2 1 0 Protein of unknown function (DUF4534) PBP1_TM PF14812.6 CDI84962.1 - 0.087 13.2 5.7 0.81 10.1 3.9 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SOBP PF15279.6 CDI84962.1 - 0.088 13.4 30.9 0.091 13.4 30.9 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Connexin PF00029.19 CDI84962.1 - 0.18 11.6 30.4 1 9.0 20.5 2.1 1 1 1 2 2 2 0 Connexin SAGA-Tad1 PF12767.7 CDI84962.1 - 0.2 11.4 22.8 0.25 11.0 22.8 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit LAP1C PF05609.12 CDI84962.1 - 0.3 10.1 31.5 0.37 9.8 31.5 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) LRRC37AB_C PF14914.6 CDI84962.1 - 0.31 10.9 26.5 1.4 8.8 17.1 2.3 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain PAT1 PF09770.9 CDI84962.1 - 0.55 8.4 52.4 0.61 8.3 52.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Na_trans_assoc PF06512.13 CDI84962.1 - 0.68 10.2 16.9 0.93 9.7 16.9 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated Hid1 PF12722.7 CDI84962.1 - 0.9 7.6 28.7 1.1 7.3 28.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PNISR PF15996.5 CDI84962.1 - 1.1 9.5 36.7 1.6 9.0 36.7 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR NST1 PF13945.6 CDI84962.1 - 1.1 9.3 39.6 1 9.4 3.3 2.3 2 0 0 2 2 2 0 Salt tolerance down-regulator Sulf_transp PF04143.14 CDI84962.1 - 1.1 8.7 2.2 0.76 9.3 0.9 1.3 1 1 0 1 1 1 0 Sulphur transport Membralin PF09746.9 CDI84962.1 - 1.4 7.9 20.2 1.8 7.5 20.2 1.2 1 0 0 1 1 1 0 Tumour-associated protein Caldesmon PF02029.15 CDI84962.1 - 3.4 6.3 29.4 5.6 5.6 29.4 1.3 1 0 0 1 1 1 0 Caldesmon SARG PF15385.6 CDI84962.1 - 3.6 6.7 33.5 5 6.2 33.5 1.1 1 0 0 1 1 1 0 Specifically androgen-regulated gene protein Ndc1_Nup PF09531.10 CDI84962.1 - 3.8 6.1 30.9 4.3 5.9 30.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3295 PF11702.8 CDI84962.1 - 5.6 6.2 34.4 6.9 5.9 34.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Hamartin PF04388.12 CDI84962.1 - 6.1 5.4 30.8 6.9 5.2 30.8 1.1 1 0 0 1 1 1 0 Hamartin protein DUF3675 PF12428.8 CDI84962.1 - 6.5 7.3 12.8 23 5.6 6.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3675) DUF4366 PF14283.6 CDI84962.1 - 6.8 6.7 23.2 5 7.2 0.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) Slu7 PF11708.8 CDI84962.1 - 7.8 6.2 29.0 4.7 6.9 1.0 2.2 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor RskA PF10099.9 CDI84965.1 - 0.00068 20.0 2.9 0.00068 20.0 2.9 5.4 1 1 3 4 4 4 1 Anti-sigma-K factor rskA Pex14_N PF04695.13 CDI84965.1 - 0.0079 16.9 10.5 0.0079 16.9 10.5 3.7 2 1 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region VIT1 PF01988.19 CDI84965.1 - 0.0086 16.0 9.6 0.0086 16.0 9.6 3.4 3 1 1 4 4 4 1 VIT family FAM199X PF15814.5 CDI84965.1 - 0.0096 15.0 7.3 0.0096 15.0 7.3 4.5 1 1 4 5 5 5 1 Protein family FAM199X SDA1 PF05285.12 CDI84965.1 - 2.5 7.4 61.4 4.2 6.7 16.0 2.3 2 0 0 2 2 2 0 SDA1 DUF5058 PF16481.5 CDI84965.1 - 3.9 7.1 10.5 0.45 10.2 4.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5058) DUF3807 PF12720.7 CDI84965.1 - 8.6 6.6 78.5 0.36 11.1 23.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) Spt20 PF12090.8 CDI84966.1 - 0.00013 21.6 14.4 0.00013 21.6 14.4 1.1 1 0 0 1 1 1 1 Spt20 family Med15 PF09606.10 CDI84966.1 - 0.0026 16.5 11.9 0.0026 16.5 11.9 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI84966.1 - 0.0074 16.3 14.4 0.0086 16.1 14.4 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF4407 PF14362.6 CDI84966.1 - 0.065 12.6 6.1 0.082 12.3 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pex14_N PF04695.13 CDI84966.1 - 0.074 13.7 13.6 0.091 13.4 13.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ribosomal_60s PF00428.19 CDI84966.1 - 0.31 11.7 11.8 0.5 11.0 11.8 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Suf PF05843.14 CDI84966.1 - 0.56 10.1 8.8 0.61 10.0 8.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) UPF0560 PF10577.9 CDI84966.1 - 0.84 8.1 7.5 0.85 8.0 7.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4834 PF16118.5 CDI84966.1 - 0.97 10.4 7.0 1.3 10.0 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3138 PF11336.8 CDI84966.1 - 1.8 7.1 9.7 2.1 6.9 9.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Activator_LAG-3 PF11498.8 CDI84966.1 - 3.6 6.4 30.0 4 6.3 30.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Eapp_C PF10238.9 CDI84967.1 - 1.4e-15 57.7 4.7 1.4e-15 57.7 4.7 9.2 8 3 1 9 9 9 1 E2F-associated phosphoprotein IBR PF01485.21 CDI84967.1 - 0.023 14.9 0.2 0.1 12.8 0.2 2.2 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain ADK PF00406.22 CDI84968.1 - 2.3e-09 37.5 1.1 1.1e-07 32.1 0.0 2.5 2 1 0 2 2 2 1 Adenylate kinase Pex14_N PF04695.13 CDI84968.1 - 0.026 15.2 19.0 0.026 15.2 19.0 4.2 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PAT1 PF09770.9 CDI84968.1 - 0.031 12.5 74.2 0.0057 15.0 39.4 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Scs3p PF10261.9 CDI84968.1 - 0.12 11.9 12.5 0.093 12.2 2.6 2.4 2 0 0 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM Oxidored_q3 PF00499.20 CDI84968.1 - 0.13 12.0 0.0 0.38 10.5 0.0 1.8 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Zip PF02535.22 CDI84968.1 - 0.89 8.7 18.6 0.7 9.0 0.1 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter SpoIIIAH PF12685.7 CDI84968.1 - 0.95 9.3 44.2 1 9.1 12.9 3.2 3 0 0 3 3 3 0 SpoIIIAH-like protein Exonuc_VII_L PF02601.15 CDI84968.1 - 2.4 7.7 48.7 1.2 8.7 27.6 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit ASC PF00858.24 CDI84968.1 - 7.3 5.4 18.9 0.053 12.5 0.2 2.2 2 0 0 2 2 2 0 Amiloride-sensitive sodium channel PCMT PF01135.19 CDI84969.1 - 2.9e-19 69.7 0.1 6.6e-19 68.5 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SUIM_assoc PF16619.5 CDI84969.1 - 2.1e-07 30.9 5.3 0.0002 21.4 0.3 2.3 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 M_domain PF12938.7 CDI84969.1 - 0.0038 17.1 7.1 0.0038 17.1 7.1 2.4 2 0 0 2 2 2 2 M domain of GW182 NINJA_B PF16136.5 CDI84969.1 - 0.081 13.3 4.4 0.33 11.4 0.4 2.6 2 0 0 2 2 2 0 Putative nuclear localisation signal DUF1635 PF07795.11 CDI84969.1 - 0.19 11.5 11.8 0.089 12.6 4.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DUF4834 PF16118.5 CDI84969.1 - 0.23 12.5 3.5 5.9 7.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) ANAPC_CDC26 PF10471.9 CDI84969.1 - 0.25 12.2 17.1 1 10.2 3.7 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Spt20 PF12090.8 CDI84969.1 - 0.29 10.7 17.7 0.074 12.7 3.2 2.1 2 0 0 2 2 2 0 Spt20 family SR-25 PF10500.9 CDI84969.1 - 0.32 10.6 12.4 0.12 12.0 9.3 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI84969.1 - 0.55 10.9 7.1 1.4 9.6 7.1 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein Lin-8 PF03353.15 CDI84969.1 - 0.95 9.0 5.6 0.82 9.2 0.8 2.0 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist AF-4 PF05110.13 CDI84969.1 - 2.2 6.3 13.2 0.4 8.7 8.7 1.7 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Arf PF00025.21 CDI84970.1 - 1.2e-21 76.9 1.5 2.3e-20 72.8 0.0 3.3 1 1 2 3 3 3 1 ADP-ribosylation factor family Roc PF08477.13 CDI84970.1 - 5.2e-07 29.9 0.0 5.2e-07 29.9 0.0 3.3 3 1 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase RskA PF10099.9 CDI84970.1 - 0.00034 21.0 51.4 0.0042 17.4 22.7 3.8 3 1 0 3 3 3 3 Anti-sigma-K factor rskA DUF4179 PF13786.6 CDI84970.1 - 0.065 13.7 0.1 0.065 13.7 0.1 3.8 4 1 0 4 4 4 0 Domain of unknown function (DUF4179) AAA_18 PF13238.6 CDI84970.1 - 0.068 13.7 0.0 0.068 13.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain Utp14 PF04615.13 CDI84970.1 - 0.16 10.5 45.4 0.28 9.7 45.4 1.3 1 0 0 1 1 1 0 Utp14 protein G-alpha PF00503.20 CDI84970.1 - 1.5 7.9 22.7 0.15 11.2 0.2 3.7 2 2 0 3 3 3 0 G-protein alpha subunit AAA_24 PF13479.6 CDI84970.1 - 3.6 7.2 0.0 3.6 7.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain 7TM_GPCR_Srh PF10318.9 CDI84973.1 - 0.017 14.2 3.0 0.027 13.5 3.0 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srh SelP_N PF04592.14 CDI84975.1 - 2 7.7 39.0 2.4 7.5 39.0 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF1180 PF06679.12 CDI84975.1 - 7.8 6.9 7.1 8.9 6.7 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Macoilin PF09726.9 CDI84976.1 - 1.4 7.4 39.5 2 6.9 39.5 1.2 1 0 0 1 1 1 0 Macoilin family LMBR1 PF04791.16 CDI84976.1 - 6.4 5.6 15.0 9.1 5.1 15.0 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein MAR_sialic_bdg PF10564.9 CDI84977.1 - 3.4e-22 78.3 1.7 5.3e-22 77.7 1.7 1.3 1 0 0 1 1 1 1 Sialic-acid binding micronemal adhesive repeat MAR_sialic_bdg PF10564.9 CDI84978.1 - 5.5e-128 417.4 46.4 2.8e-26 91.4 3.9 6.3 6 0 0 6 6 6 6 Sialic-acid binding micronemal adhesive repeat DUF1348 PF07080.11 CDI84978.1 - 0.073 13.0 0.0 27 4.7 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1348) zf-C3HC4_3 PF13920.6 CDI84978.1 - 0.19 11.6 2.9 10 6.1 0.4 3.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SQHop_cyclase_C PF13243.6 CDI84981.1 - 0.024 13.7 0.1 0.037 13.1 0.1 1.3 1 0 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain Prenyltrans PF00432.21 CDI84981.1 - 0.092 12.5 0.1 0.25 11.1 0.1 1.7 1 0 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat Stm1_N PF09598.10 CDI84981.1 - 8.5 7.3 10.4 6.2 7.8 4.2 2.7 2 0 0 2 2 2 0 Stm1 BRO1 PF03097.18 CDI84982.1 - 2e-21 76.3 2.0 2e-18 66.4 3.3 4.5 4 2 0 4 4 4 2 BRO1-like domain Cellulose_synt PF03552.14 CDI84982.1 - 5.3 5.4 4.8 12 4.2 4.8 1.6 1 0 0 1 1 1 0 Cellulose synthase Pro_isomerase PF00160.21 CDI84984.1 - 5.1e-35 121.1 0.0 1.3e-34 119.7 0.0 1.6 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Adeno_PIX PF03955.14 CDI84984.1 - 0.032 14.4 0.9 0.058 13.6 0.9 1.3 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) RskA PF10099.9 CDI84984.1 - 0.45 10.8 5.0 0.12 12.6 2.0 1.5 2 0 0 2 2 2 0 Anti-sigma-K factor rskA CLAMP PF14769.6 CDI84985.1 - 1.1e-18 67.5 0.2 2.1e-18 66.6 0.2 1.4 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 FtsH_ext PF06480.15 CDI84985.1 - 0.045 14.1 0.0 0.17 12.3 0.1 1.9 2 0 0 2 2 2 0 FtsH Extracellular NRDE-2 PF08424.10 CDI84985.1 - 0.15 11.1 4.8 0.086 12.0 3.0 1.4 2 0 0 2 2 2 0 NRDE-2, necessary for RNA interference DNA_pol_B PF00136.21 CDI84986.1 - 1.1e-132 443.0 3.1 2.8e-132 441.7 3.1 1.6 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CDI84986.1 - 6.3e-60 203.1 0.0 1.5e-59 201.9 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 CDI84986.1 - 1.4e-17 63.9 7.4 3.3e-17 62.7 7.4 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 CDI84986.1 - 0.051 12.4 0.3 0.22 10.3 0.1 1.9 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral zf-RING-like PF08746.11 CDI84986.1 - 4.8 7.6 12.1 1.5 9.2 0.6 3.1 3 0 0 3 3 3 0 RING-like domain Sad1_UNC PF07738.13 CDI84988.1 - 1.1e-10 41.7 3.9 7.5e-10 38.9 3.8 2.1 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal RskA PF10099.9 CDI84988.1 - 9.1e-06 26.1 0.4 1e-05 25.9 0.4 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI84988.1 - 0.0035 16.3 15.9 0.0035 16.3 15.9 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) PH_4 PF15404.6 CDI84988.1 - 0.01 15.6 1.1 0.01 15.6 1.1 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain TFIIA PF03153.13 CDI84988.1 - 0.013 15.5 25.1 0.015 15.3 25.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SprA-related PF12118.8 CDI84988.1 - 0.013 14.6 23.8 0.021 14.0 23.8 1.3 1 0 0 1 1 1 0 SprA-related family Suf PF05843.14 CDI84988.1 - 0.018 15.1 22.1 0.047 13.7 22.1 1.6 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) bMG10 PF17973.1 CDI84988.1 - 0.027 14.6 0.3 0.053 13.7 0.3 1.5 1 0 0 1 1 1 0 Bacterial Alpha-2-macroglobulin MG10 domain DUF1091 PF06477.13 CDI84988.1 - 0.042 14.3 0.0 0.064 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) FHIPEP PF00771.20 CDI84988.1 - 0.054 12.0 0.5 0.064 11.7 0.5 1.1 1 0 0 1 1 1 0 FHIPEP family DUF2371 PF10177.9 CDI84988.1 - 1 9.5 4.4 0.72 10.0 0.1 2.3 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) EIIBC-GUT_N PF03612.14 CDI84988.1 - 1.6 8.5 6.9 0.28 10.9 1.4 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus AIF_C PF14721.6 CDI84988.1 - 2.6 8.4 9.9 1.5 9.2 1.8 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FlaG PF03646.15 CDI84988.1 - 4.8 7.4 18.2 0.096 12.9 7.5 2.3 2 0 0 2 2 2 0 FlaG protein Ndc1_Nup PF09531.10 CDI84988.1 - 5.2 5.6 20.7 6.7 5.3 20.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup EPL1 PF10513.9 CDI84988.1 - 6 7.2 16.4 2.7 8.4 5.6 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like Folate_carrier PF01770.18 CDI84988.1 - 6.5 5.4 7.2 0.42 9.3 1.2 1.8 2 0 0 2 2 2 0 Reduced folate carrier Utp14 PF04615.13 CDI84989.1 - 0.2 10.2 14.0 0.26 9.8 14.0 1.1 1 0 0 1 1 1 0 Utp14 protein TFIIA PF03153.13 CDI84989.1 - 2.7 7.9 23.0 4.3 7.2 23.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hid1 PF12722.7 CDI84989.1 - 2.8 5.9 13.1 4 5.4 13.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Histone_HNS PF00816.21 CDI84989.1 - 3.3 8.6 11.6 23 5.9 6.1 2.6 2 0 0 2 2 2 0 H-NS histone family RskA PF10099.9 CDI84990.1 - 0.0037 17.6 15.9 0.0037 17.6 15.9 13.9 4 3 7 12 12 12 5 Anti-sigma-K factor rskA LRR_6 PF13516.6 CDI84990.1 - 0.0077 16.2 0.0 0.021 14.8 0.0 1.8 1 0 0 1 1 1 1 Leucine Rich repeat DUF4834 PF16118.5 CDI84991.1 - 0.0014 19.6 0.3 0.048 14.6 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4834) Oxidored_q3 PF00499.20 CDI84991.1 - 0.027 14.2 0.6 0.043 13.6 0.1 1.6 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 ABC2_membrane_2 PF12679.7 CDI84991.1 - 0.19 11.0 4.9 0.22 10.8 1.6 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein Ribosomal_60s PF00428.19 CDI84991.1 - 0.22 12.1 36.9 0.14 12.8 5.5 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF1345 PF07077.11 CDI84991.1 - 0.25 11.0 5.3 0.13 12.0 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) Tox-PL-2 PF15643.6 CDI84991.1 - 0.33 11.1 2.4 13 6.0 0.2 2.4 2 0 0 2 2 2 0 Papain fold toxin 2 K_channel_TID PF07941.11 CDI84991.1 - 2.7 8.5 39.2 2.6 8.6 9.0 3.6 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain WBP-1 PF11669.8 CDI84991.1 - 5.1 7.8 5.4 1.3 9.7 0.2 2.6 2 1 0 3 3 3 0 WW domain-binding protein 1 N6_N4_Mtase PF01555.18 CDI84992.1 - 1.1e-05 25.2 0.2 33 4.1 0.0 5.6 3 3 0 3 3 3 2 DNA methylase Spt20 PF12090.8 CDI84992.1 - 0.002 17.8 14.5 0.002 17.8 14.5 14.9 7 4 6 14 14 14 2 Spt20 family RskA PF10099.9 CDI84992.1 - 0.064 13.5 0.0 0.064 13.5 0.0 17.5 2 2 9 13 13 13 0 Anti-sigma-K factor rskA MMR1 PF08505.10 CDI84993.1 - 0.0067 16.7 17.7 0.0067 16.7 17.7 3.8 2 1 3 5 5 5 1 Mitochondrial Myo2 receptor-related protein Cwf_Cwc_15 PF04889.12 CDI84993.1 - 0.0092 15.7 10.0 0.0092 15.7 10.0 4.1 1 1 1 3 3 3 1 Cwf15/Cwc15 cell cycle control protein Cwf_Cwc_15 PF04889.12 CDI84994.1 - 0.17 11.6 18.6 0.23 11.1 18.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TFIIA PF03153.13 CDI84994.1 - 0.18 11.8 73.1 0.23 11.4 73.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SID-1_RNA_chan PF13965.6 CDI84994.1 - 0.89 7.9 5.4 1.1 7.5 5.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CDC27 PF09507.10 CDI84994.1 - 4.7 6.5 25.4 6.4 6.0 25.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 FUSC PF04632.12 CDI84994.1 - 5.7 5.3 38.9 7.1 5.0 38.9 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family TMEM154 PF15102.6 CDI84994.1 - 8.4 6.3 13.2 1.5 8.7 3.6 2.5 1 1 1 2 2 2 0 TMEM154 protein family Ribosomal_S25 PF03297.15 CDI84995.1 - 7.6e-41 138.4 0.7 8.5e-41 138.3 0.7 1.0 1 0 0 1 1 1 1 S25 ribosomal protein MarR_2 PF12802.7 CDI84995.1 - 0.026 14.4 0.0 0.036 13.9 0.0 1.2 1 0 0 1 1 1 0 MarR family Mt_ATP-synt_D PF05873.12 CDI84995.1 - 0.053 13.4 1.4 0.071 13.0 1.4 1.1 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Rrf2 PF02082.20 CDI84995.1 - 0.1 13.0 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator E_Pc_C PF06752.12 CDI84997.1 - 2.1 8.4 12.6 2.5 8.2 12.6 1.1 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus DUF3138 PF11336.8 CDI84997.1 - 3.3 6.2 12.2 3.4 6.2 12.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Shadoo PF14999.6 CDI84997.1 - 3.3 7.8 12.1 4.2 7.5 12.1 1.1 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective DUF5588 PF17826.1 CDI84998.1 - 1.9 7.3 10.9 2.3 7.0 10.9 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF5588) PP2C_2 PF13672.6 CDI84998.1 - 5.7 6.5 12.0 6.8 6.3 12.0 1.1 1 0 0 1 1 1 0 Protein phosphatase 2C Integrase_H2C2 PF17921.1 CDI84999.1 - 1.6e-16 60.2 1.3 3.4e-16 59.1 1.3 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 CDI84999.1 - 1.4e-14 54.1 0.0 2.6e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CDI84999.1 - 2.5e-12 47.1 0.0 6.8e-12 45.6 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Chromo PF00385.24 CDI84999.1 - 1.7e-09 37.4 0.0 3.5e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 CDI84999.1 - 0.0015 18.7 0.3 0.0032 17.7 0.3 1.6 1 0 0 1 1 1 1 H2C2 zinc finger DEC-1_N PF04625.13 CDI84999.1 - 0.06 12.3 0.7 0.1 11.6 0.7 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region PKS_DE PF18369.1 CDI84999.1 - 0.43 11.2 5.2 16 6.2 3.1 3.2 3 0 0 3 3 3 0 Polyketide synthase dimerisation element domain Asp_protease_2 PF13650.6 CDI85000.1 - 1.3e-06 29.0 0.0 2.6e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 CDI85000.1 - 3.9e-06 26.7 0.0 0.001 18.8 0.0 2.3 1 1 1 2 2 2 2 Retroviral aspartyl protease gag-asp_proteas PF13975.6 CDI85000.1 - 1.7e-05 25.2 0.0 4.9e-05 23.8 0.0 1.8 1 1 1 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 CDI85000.1 - 0.014 15.1 0.0 0.29 10.9 0.0 2.1 1 1 1 2 2 2 0 Aspartyl protease RVP PF00077.20 CDI85000.1 - 0.049 14.0 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease Caldesmon PF02029.15 CDI85003.1 - 4 6.1 47.8 6.1 5.5 47.8 1.4 1 0 0 1 1 1 0 Caldesmon SR-25 PF10500.9 CDI85003.1 - 4.1 7.0 43.7 0.18 11.4 15.5 3.1 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein XTBD PF11952.8 CDI85005.1 - 0.0002 21.1 0.1 0.00042 20.0 0.1 1.6 1 1 0 1 1 1 1 XRN-Two Binding Domain, XTBD Tim54 PF11711.8 CDI85006.1 - 0.0021 16.9 12.3 0.0032 16.3 12.3 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Presenilin PF01080.17 CDI85006.1 - 0.0023 16.8 16.7 0.0029 16.4 16.7 1.1 1 0 0 1 1 1 1 Presenilin O-antigen_lig PF13425.6 CDI85006.1 - 0.0029 16.5 4.2 0.0035 16.2 4.2 1.1 1 0 0 1 1 1 1 O-antigen ligase like membrane protein DUF4834 PF16118.5 CDI85006.1 - 0.0034 18.3 22.4 0.18 12.8 1.7 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) V_ATPase_I PF01496.19 CDI85006.1 - 0.011 13.7 16.2 0.013 13.5 16.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2828 PF11443.8 CDI85006.1 - 0.014 13.6 10.9 0.016 13.3 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SLC12 PF03522.15 CDI85006.1 - 0.043 12.9 15.4 0.051 12.6 15.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF2126 PF09899.9 CDI85006.1 - 0.052 11.6 9.3 0.056 11.5 9.3 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF913 PF06025.12 CDI85006.1 - 0.055 12.4 7.5 0.073 12.0 7.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4820 PF16091.5 CDI85006.1 - 0.076 12.4 16.1 0.47 9.8 8.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) HemX PF04375.14 CDI85006.1 - 0.11 11.8 34.5 0.14 11.4 34.5 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Spt20 PF12090.8 CDI85006.1 - 0.12 12.0 63.6 0.19 11.3 16.8 2.1 2 0 0 2 2 2 0 Spt20 family U1snRNP70_N PF12220.8 CDI85006.1 - 0.14 12.8 17.2 1.4 9.6 0.7 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF1156 PF06634.12 CDI85006.1 - 0.15 12.2 0.0 0.15 12.2 0.0 2.5 2 1 0 2 2 1 0 Protein of unknown function (DUF1156) RNA_pol_Rbc25 PF08292.12 CDI85006.1 - 0.15 12.3 15.2 0.54 10.5 0.5 2.1 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 Eapp_C PF10238.9 CDI85006.1 - 0.16 12.0 18.9 1.4 8.9 0.9 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein Neur_chan_memb PF02932.16 CDI85006.1 - 0.17 11.9 13.2 0.23 11.5 13.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF719 PF05334.13 CDI85006.1 - 0.18 12.0 16.2 1.1 9.5 7.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF719) Porph_ging PF09697.10 CDI85006.1 - 0.28 11.7 10.7 2.8 8.6 5.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) UPF0239 PF06783.11 CDI85006.1 - 0.29 11.3 16.0 0.4 10.9 1.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) CAF1 PF04857.20 CDI85006.1 - 0.36 9.9 10.2 0.44 9.7 10.2 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease CobT PF06213.12 CDI85006.1 - 0.37 10.1 28.0 0.33 10.3 2.7 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT EIIBC-GUT_N PF03612.14 CDI85006.1 - 0.38 10.5 18.4 2 8.1 0.6 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Peroxin-13_N PF04088.13 CDI85006.1 - 0.41 10.9 11.5 1.4 9.2 5.4 2.1 2 0 0 2 2 2 0 Peroxin 13, N-terminal region TMEM51 PF15345.6 CDI85006.1 - 0.56 10.0 26.6 1.6 8.5 15.7 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 MAT1 PF06391.13 CDI85006.1 - 0.56 10.0 27.9 1.5 8.6 2.2 2.1 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 AUX_IAA PF02309.16 CDI85006.1 - 0.57 10.0 12.1 0.74 9.6 12.1 1.1 1 0 0 1 1 1 0 AUX/IAA family DUF1178 PF06676.11 CDI85006.1 - 0.58 10.5 19.6 1.4 9.3 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) AIF_C PF14721.6 CDI85006.1 - 0.62 10.4 15.3 4.2 7.7 0.2 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term HemY_N PF07219.13 CDI85006.1 - 0.66 10.2 0.0 0.66 10.2 0.0 2.5 2 1 0 2 2 1 0 HemY protein N-terminus FAM176 PF14851.6 CDI85006.1 - 0.69 9.6 12.7 6.4 6.4 0.2 2.1 2 0 0 2 2 2 0 FAM176 family WRNPLPNID PF15017.6 CDI85006.1 - 0.79 10.6 13.0 3.5 8.6 0.4 2.3 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box DUF3408 PF11888.8 CDI85006.1 - 0.86 9.7 20.8 2.9 8.0 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) TFB6 PF17110.5 CDI85006.1 - 0.91 9.2 11.8 5.5 6.7 6.3 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH HA2 PF04408.23 CDI85006.1 - 1 9.7 11.4 3.8 7.8 0.3 2.1 2 0 0 2 2 2 0 Helicase associated domain (HA2) DUF3357 PF11837.8 CDI85006.1 - 1.1 9.8 4.7 2.4 8.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) EPL1 PF10513.9 CDI85006.1 - 1.1 9.6 23.1 2.6 8.4 2.3 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like eIF_4EBP PF05456.11 CDI85006.1 - 1.1 9.2 16.0 2.4 8.1 0.9 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Peptidase_S49_N PF08496.10 CDI85006.1 - 1.4 9.0 18.1 3.1 7.8 0.2 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal PRP1_N PF06424.12 CDI85006.1 - 1.4 9.3 17.9 1.8 8.9 0.6 2.1 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Sec62 PF03839.16 CDI85006.1 - 1.5 8.3 13.0 6.2 6.3 8.2 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 Hid1 PF12722.7 CDI85006.1 - 1.5 6.9 15.5 1.6 6.7 15.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3464 PF11947.8 CDI85006.1 - 1.5 8.6 21.6 1.1 9.0 0.8 2.1 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DUF1764 PF08576.10 CDI85006.1 - 1.7 9.6 17.7 7.7 7.5 0.4 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) GRP PF07172.11 CDI85006.1 - 1.7 9.4 6.1 5 7.9 0.1 2.2 2 0 0 2 2 2 0 Glycine rich protein family Thg1C PF14413.6 CDI85006.1 - 2.5 8.3 19.1 2.5 8.3 0.6 2.2 2 0 0 2 2 2 0 Thg1 C terminal domain DUF2076 PF09849.9 CDI85006.1 - 2.6 8.0 42.3 3.4 7.6 42.3 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) BRF1 PF07741.13 CDI85006.1 - 2.8 8.3 17.9 7.1 7.0 0.2 2.1 2 0 0 2 2 2 0 Brf1-like TBP-binding domain T2SSC PF11356.8 CDI85006.1 - 3.7 7.4 16.0 0.6 10.0 2.0 2.1 2 0 0 2 2 2 0 Type II secretion system protein C DUF979 PF06166.12 CDI85006.1 - 3.8 6.6 8.0 0.29 10.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF979) ORC_WH_C PF18137.1 CDI85006.1 - 4.2 7.4 19.0 2.4 8.2 0.6 2.0 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Mss4 PF04421.13 CDI85006.1 - 4.5 7.5 9.4 7.6 6.7 0.0 2.3 2 0 0 2 2 2 0 Mss4 protein tRNA_synt_1c_R2 PF04557.15 CDI85006.1 - 4.7 8.2 17.3 5.1 8.1 0.3 2.1 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Jak1_Phl PF17887.1 CDI85006.1 - 5 7.1 19.5 3.9 7.4 0.5 2.1 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain MDM31_MDM32 PF08118.11 CDI85006.1 - 8 5.0 14.0 3.9 6.0 7.1 2.0 2 0 0 2 2 2 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF1980 PF09323.10 CDI85006.1 - 9.1 6.1 15.2 9.8 6.0 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF3381 PF11861.8 CDI85006.1 - 9.4 6.0 26.6 4.6 7.0 3.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Isy1 PF06246.12 CDI85007.1 - 1.3 8.6 26.2 1.5 8.4 16.2 2.1 2 0 0 2 2 2 0 Isy1-like splicing family DNA_pol_A_exo1 PF01612.20 CDI85009.1 - 5.4e-32 110.9 0.0 8.2e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease HIRAN PF08797.11 CDI85009.1 - 0.12 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 HIRAN domain Bac_luciferase PF00296.20 CDI85011.1 - 0.01 15.3 17.2 0.012 15.0 17.2 1.0 1 0 0 1 1 1 0 Luciferase-like monooxygenase SprA-related PF12118.8 CDI85011.1 - 0.034 13.3 25.6 0.047 12.8 25.6 1.1 1 0 0 1 1 1 0 SprA-related family Suf PF05843.14 CDI85011.1 - 0.036 14.1 6.2 0.032 14.2 6.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 CDI85011.1 - 0.04 13.9 26.2 0.047 13.7 26.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 CDI85011.1 - 0.072 12.1 6.0 0.066 12.2 6.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TERB2 PF15101.6 CDI85011.1 - 0.12 12.4 9.1 0.16 12.0 9.1 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 STAG PF08514.11 CDI85011.1 - 0.19 11.7 4.5 0.35 10.8 4.5 1.5 1 0 0 1 1 1 0 STAG domain Roughex PF06020.11 CDI85011.1 - 0.28 10.3 7.4 0.3 10.1 7.4 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Neur_chan_memb PF02932.16 CDI85011.1 - 0.29 11.2 2.3 0.29 11.2 2.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CLN3 PF02487.17 CDI85011.1 - 0.41 9.6 2.1 0.46 9.5 2.1 1.2 1 0 0 1 1 1 0 CLN3 protein RR_TM4-6 PF06459.12 CDI85011.1 - 0.48 10.2 7.6 0.54 10.0 7.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Connexin PF00029.19 CDI85011.1 - 0.71 9.6 3.3 0.81 9.4 3.3 1.1 1 0 0 1 1 1 0 Connexin Serinc PF03348.15 CDI85011.1 - 0.92 8.4 4.4 0.98 8.3 4.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Presenilin PF01080.17 CDI85011.1 - 1 8.1 10.5 1.1 7.9 10.5 1.1 1 0 0 1 1 1 0 Presenilin CDC27 PF09507.10 CDI85011.1 - 3.2 7.1 15.6 3.8 6.8 15.6 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Spt20 PF12090.8 CDI85011.1 - 4.7 6.8 27.2 6.6 6.3 27.2 1.2 1 0 0 1 1 1 0 Spt20 family DUF3464 PF11947.8 CDI85011.1 - 5.7 6.7 8.3 13 5.6 8.3 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Med15 PF09606.10 CDI85011.1 - 6.3 5.3 26.2 9 4.8 26.2 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3357 PF11837.8 CDI85012.1 - 5.5e-06 26.8 0.0 0.038 14.4 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF3357) Conotoxin PF02950.17 CDI85012.1 - 1.2e-05 26.2 13.4 0.0043 18.0 0.3 3.6 1 1 3 4 4 4 2 Conotoxin DUF1345 PF07077.11 CDI85012.1 - 9e-05 22.2 0.1 0.25 11.0 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1345) EphA2_TM PF14575.6 CDI85012.1 - 9.1e-05 23.3 0.1 0.48 11.3 0.0 3.2 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain DUF1505 PF07403.11 CDI85012.1 - 0.00029 21.0 0.0 0.84 9.8 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1505) TctB PF07331.11 CDI85012.1 - 0.0021 18.3 0.0 0.77 10.0 0.1 2.3 2 0 0 2 2 2 1 Tripartite tricarboxylate transporter TctB family Baculo_11_kDa PF06143.11 CDI85012.1 - 0.0026 17.3 5.4 2.7 7.6 0.4 3.4 2 1 1 3 3 3 1 Baculovirus 11 kDa family Salp15 PF12115.8 CDI85012.1 - 0.0029 18.0 3.4 4.3 7.8 0.2 3.2 1 1 2 3 3 3 0 Salivary protein of 15kDa inhibits CD4+ T cell activation tRNA_anti-like PF12869.7 CDI85012.1 - 0.0029 17.2 8.4 0.18 11.4 1.3 2.3 1 1 1 2 2 2 2 tRNA_anti-like Oxidored_q3 PF00499.20 CDI85012.1 - 0.004 16.9 0.0 0.81 9.4 0.0 2.1 2 0 0 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 O-antigen_lig PF13425.6 CDI85012.1 - 0.0043 15.9 6.8 0.099 11.4 0.9 2.1 1 1 1 2 2 2 2 O-antigen ligase like membrane protein Auxin_canalis PF05703.11 CDI85012.1 - 0.0052 16.7 4.9 0.057 13.4 1.0 2.0 2 0 0 2 2 2 1 Auxin canalisation DUF2615 PF11027.8 CDI85012.1 - 0.0063 16.6 0.0 4.9 7.3 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2615) RskA PF10099.9 CDI85012.1 - 0.0074 16.6 0.0 1.8 8.8 0.0 2.0 2 0 0 2 2 2 1 Anti-sigma-K factor rskA DUF2140 PF09911.9 CDI85012.1 - 0.0089 15.6 1.6 4.5 6.8 0.1 2.8 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF2637 PF10935.8 CDI85012.1 - 0.011 15.6 1.6 2.8 7.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2637) DUF2771 PF10969.8 CDI85012.1 - 0.012 15.7 10.1 0.24 11.5 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2771) SARAF PF06682.12 CDI85012.1 - 0.015 15.0 0.7 0.72 9.4 0.2 2.2 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4448 PF14610.6 CDI85012.1 - 0.015 15.1 0.1 4.2 7.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) ECSCR PF15820.5 CDI85012.1 - 0.021 14.6 1.1 5.3 6.9 0.1 2.3 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator DUF3367 PF11847.8 CDI85012.1 - 0.023 12.6 0.5 0.92 7.3 0.1 2.0 2 0 0 2 2 2 0 Alpha-(1->3)-arabinofuranosyltransferase DUF3836 PF12930.7 CDI85012.1 - 0.024 14.4 0.3 6.9 6.4 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF3836) SSF PF00474.17 CDI85012.1 - 0.025 13.4 5.3 1 8.2 0.3 2.0 2 0 0 2 2 2 0 Sodium:solute symporter family DUF3515 PF12028.8 CDI85012.1 - 0.026 14.3 2.9 3.4 7.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3515) DUF898 PF05987.13 CDI85012.1 - 0.032 13.3 0.0 0.083 11.9 0.0 1.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) DUF4576 PF15144.6 CDI85012.1 - 0.048 13.5 4.3 2.4 8.1 0.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4576) COX6A PF02046.15 CDI85012.1 - 0.11 13.0 2.6 8.6 6.9 0.1 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIa Ninjurin PF04923.12 CDI85012.1 - 0.14 12.1 0.6 16 5.5 0.1 2.2 2 0 0 2 2 2 0 Ninjurin DUF3742 PF12553.8 CDI85012.1 - 0.14 12.2 15.9 0.79 9.9 1.2 3.5 1 1 3 4 4 3 0 Protein of unknown function (DUF3742) DBC1 PF14443.6 CDI85012.1 - 0.2 11.6 9.6 0.53 10.3 1.4 2.1 2 0 0 2 2 2 0 DBC1 PUCC PF03209.15 CDI85012.1 - 0.23 10.4 3.1 3.9 6.4 0.1 2.1 2 0 0 2 2 2 0 PUCC protein DUF2371 PF10177.9 CDI85012.1 - 0.32 11.2 0.9 24 5.1 0.0 2.5 1 1 1 3 3 3 0 Uncharacterised conserved protein (DUF2371) SAPS PF04499.15 CDI85012.1 - 0.4 9.4 17.5 0.56 8.9 17.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein ORC_WH_C PF18137.1 CDI85012.1 - 0.59 10.2 24.8 0.16 12.0 4.4 2.2 1 1 1 2 2 2 0 Origin recognition complex winged helix C-terminal Connexin PF00029.19 CDI85012.1 - 0.71 9.6 17.6 2.3e+03 -1.9 17.6 3.0 1 1 0 1 1 1 0 Connexin Afi1 PF07792.12 CDI85012.1 - 1.2 9.7 30.6 0.5 10.8 10.8 2.2 1 1 1 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2749 PF10907.8 CDI85012.1 - 1.3 9.3 6.2 18 5.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) Peptidase_S49_N PF08496.10 CDI85012.1 - 1.7 8.7 14.2 1.6 8.8 1.7 2.8 1 1 2 3 3 3 0 Peptidase family S49 N-terminal Imm5 PF14423.6 CDI85012.1 - 1.8 8.8 24.3 3.7 7.7 7.8 2.1 2 0 0 2 2 2 0 Immunity protein Imm5 Herpes_UL49_5 PF05702.11 CDI85012.1 - 2 8.5 7.0 11 6.2 0.5 2.3 1 1 1 2 2 2 0 Herpesvirus UL49.5 envelope/tegument protein BAF1_ABF1 PF04684.13 CDI85012.1 - 4.2 6.3 21.9 1.4 7.8 4.7 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor ACC_epsilon PF13822.6 CDI85012.1 - 4.2 8.1 21.7 7.1 7.4 5.5 2.6 2 1 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit Tweety PF04906.13 CDI85012.1 - 5.6 5.5 0.0 5.6 5.5 0.0 2.5 3 1 1 4 4 3 0 Tweety FHIPEP PF00771.20 CDI85012.1 - 6.2 5.2 9.5 4.5e+02 -1.0 9.5 2.2 1 1 0 1 1 1 0 FHIPEP family Stig1 PF04885.13 CDI85012.1 - 6.5 7.2 8.7 16 5.9 0.8 2.7 1 1 1 2 2 2 0 Stigma-specific protein, Stig1 Med15 PF09606.10 CDI85013.1 - 0.059 12.0 47.5 0.076 11.7 47.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Mit_KHE1 PF10173.9 CDI85013.1 - 0.074 13.1 4.9 0.36 10.9 0.3 2.6 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related Coiled-coil_56 PF09813.9 CDI85013.1 - 0.2 11.7 10.0 0.39 10.8 1.7 2.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 56 PCEMA1 PF07418.11 CDI85013.1 - 0.23 11.0 7.1 0.17 11.4 2.5 2.1 2 0 0 2 2 2 0 Acidic phosphoprotein precursor PCEMA1 Activator_LAG-3 PF11498.8 CDI85013.1 - 0.41 9.6 45.6 0.17 10.8 19.6 2.7 2 0 0 2 2 2 0 Transcriptional activator LAG-3 DUF3381 PF11861.8 CDI85013.1 - 0.69 9.7 25.5 0.28 11.0 8.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) TMEM247 PF15444.6 CDI85013.1 - 2.3 8.2 14.2 1.1 9.2 4.0 2.7 2 0 0 2 2 2 0 Transmembrane protein 247 SR-25 PF10500.9 CDI85014.1 - 0.00033 20.3 12.0 0.00033 20.3 12.0 2.0 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 CDI85014.1 - 0.11 10.8 13.4 0.19 10.0 13.4 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4603 PF15376.6 CDI85014.1 - 0.33 8.3 10.2 0.51 7.7 10.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) DUF3381 PF11861.8 CDI85014.1 - 4.9 6.9 10.0 14 5.5 10.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) FAM199X PF15814.5 CDI85014.1 - 6.2 5.8 25.4 1 8.3 13.3 2.2 2 0 0 2 2 2 0 Protein family FAM199X SOBP PF15279.6 CDI85014.1 - 7.7 7.0 10.9 14 6.2 10.8 1.4 1 1 0 1 1 1 0 Sine oculis-binding protein DUF3729 PF12526.8 CDI85014.1 - 9 7.9 13.4 3.3 9.3 7.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3729) SR-25 PF10500.9 CDI85015.1 - 0.0062 16.2 1.6 0.01 15.5 1.6 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein HAUS6_N PF14661.6 CDI85015.1 - 0.073 12.6 13.6 0.098 12.2 13.6 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus TFIIA PF03153.13 CDI85015.1 - 0.78 9.7 42.1 1.1 9.1 42.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ABC2_membrane_3 PF12698.7 CDI85015.1 - 1.5 7.9 3.1 1.7 7.6 3.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Med15 PF09606.10 CDI85015.1 - 2.1 6.9 39.4 2.7 6.6 39.4 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Neur_chan_memb PF02932.16 CDI85015.1 - 3.7 7.5 6.8 4.5 7.3 6.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF648 PF04890.13 CDI85015.1 - 4.5 7.0 12.0 5.9 6.6 12.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF648) Endonuc_Holl PF10107.9 CDI85015.1 - 7.2 6.4 7.6 13 5.6 7.6 1.4 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase TCP PF03634.13 CDI85015.1 - 8.4 6.9 15.2 6.9 7.2 13.7 1.7 1 1 0 1 1 1 0 TCP family transcription factor Folate_carrier PF01770.18 CDI85016.1 - 0.42 9.3 5.3 0.65 8.7 5.3 1.3 1 0 0 1 1 1 0 Reduced folate carrier CBP_BcsG PF11658.8 CDI85016.1 - 1.7 7.0 8.5 2.3 6.5 8.5 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG CSG2 PF16965.5 CDI85016.1 - 3.1 6.7 7.0 4.9 6.0 7.0 1.5 1 0 0 1 1 1 0 Ceramide synthase regulator FPN1 PF06963.12 CDI85016.1 - 8.9 4.8 4.7 12 4.3 4.7 1.3 1 0 0 1 1 1 0 Ferroportin1 (FPN1) PAP_assoc PF03828.19 CDI85017.1 - 0.00011 22.3 0.1 0.0046 17.1 0.1 2.8 2 0 0 2 2 2 1 Cid1 family poly A polymerase DAHP_synth_2 PF01474.16 CDI85018.1 - 3.6e-28 98.3 0.0 4.2e-28 98.1 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family CEL_III_C PF18054.1 CDI85019.1 - 1.3 9.1 9.3 12 5.9 9.3 2.0 1 1 0 1 1 1 0 CEL-III C-terminal TFIIA PF03153.13 CDI85021.1 - 0.00012 22.2 53.6 0.00019 21.6 53.6 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI85021.1 - 0.21 9.8 38.6 0.27 9.5 38.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FHIPEP PF00771.20 CDI85021.1 - 0.31 9.4 6.1 0.43 9.0 6.1 1.3 1 0 0 1 1 1 0 FHIPEP family CytochromB561_N PF09786.9 CDI85021.1 - 7.5 5.4 40.3 9.4 5.1 40.3 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal DUF2722 PF10846.8 CDI85024.1 - 1.9e-05 23.8 3.3 1.9e-05 23.8 3.3 4.9 5 0 0 5 5 5 2 Protein of unknown function (DUF2722) RskA PF10099.9 CDI85024.1 - 0.00031 21.1 19.2 0.00031 21.1 19.2 8.4 3 2 2 5 5 5 2 Anti-sigma-K factor rskA Trp_oprn_chp PF09534.10 CDI85025.1 - 0.0011 18.8 6.2 0.0021 17.9 6.2 1.4 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) HemX PF04375.14 CDI85025.1 - 0.042 13.1 12.5 0.059 12.6 12.5 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Activator_LAG-3 PF11498.8 CDI85025.1 - 0.05 12.6 15.9 0.076 12.0 15.9 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.13 CDI85025.1 - 0.055 13.5 10.6 0.081 12.9 10.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.15 CDI85025.1 - 0.21 11.1 5.4 0.28 10.7 5.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2681 PF10883.8 CDI85025.1 - 0.81 10.1 14.5 1.4 9.4 14.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DUF2722 PF10846.8 CDI85025.1 - 1 8.3 8.0 1.6 7.6 8.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF2890 PF11081.8 CDI85025.1 - 1.2 9.2 9.3 1.4 9.0 6.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) Med3 PF11593.8 CDI85025.1 - 2.3 7.3 15.6 3.9 6.6 15.6 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal MRP-S27 PF10037.9 CDI85025.1 - 4.5 6.0 8.4 6.3 5.5 8.4 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 Ribosomal_60s PF00428.19 CDI85026.1 - 0.48 11.0 30.1 1.9 9.1 12.4 3.3 3 0 0 3 3 3 0 60s Acidic ribosomal protein Presenilin PF01080.17 CDI85026.1 - 2.6 6.7 3.5 0.76 8.5 0.9 1.4 2 0 0 2 2 2 0 Presenilin 17kDa_Anti_2 PF16998.5 CDI85027.1 - 4.2e-06 26.7 2.2 4.2e-06 26.7 2.2 2.2 1 1 1 2 2 2 1 17 kDa outer membrane surface antigen DUF4770 PF15994.5 CDI85027.1 - 0.01 16.1 21.1 0.021 15.1 4.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) DUF4079 PF13301.6 CDI85027.1 - 0.023 14.8 0.0 0.74 10.0 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) K_channel_TID PF07941.11 CDI85027.1 - 0.027 14.9 3.2 0.027 14.9 3.2 7.8 3 3 3 6 6 1 0 Potassium channel Kv1.4 tandem inactivation domain D123 PF07065.14 CDI85027.1 - 0.059 12.5 15.8 0.46 9.6 4.8 2.3 2 0 0 2 2 2 0 D123 eIF-3_zeta PF05091.12 CDI85027.1 - 0.24 10.4 28.0 1 8.3 12.7 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3464 PF11947.8 CDI85027.1 - 0.44 10.3 25.8 0.29 10.9 3.6 3.0 2 1 1 3 3 3 0 Photosynthesis affected mutant 68 DUF1676 PF07898.13 CDI85027.1 - 0.94 9.5 10.0 0.27 11.3 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) DUF1644 PF07800.12 CDI85027.1 - 1.4 9.0 11.3 2.5 8.2 1.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) RuvC_III PF18541.1 CDI85027.1 - 1.6 8.6 17.0 0.99 9.3 1.8 2.5 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 MDM31_MDM32 PF08118.11 CDI85027.1 - 2 7.0 16.3 2.3 6.8 7.3 2.3 2 0 0 2 2 2 0 Yeast mitochondrial distribution and morphology (MDM) proteins Topoisom_I_N PF02919.15 CDI85027.1 - 2 7.8 12.0 2.2 7.8 1.2 2.2 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Ferlin_C PF16165.5 CDI85027.1 - 2.3 8.2 4.5 28 4.6 1.7 2.3 2 0 0 2 2 2 0 Ferlin C-terminus Folate_carrier PF01770.18 CDI85027.1 - 3.9 6.1 14.5 2.2 6.9 2.1 2.2 2 0 0 2 2 2 0 Reduced folate carrier Pet20 PF08692.10 CDI85027.1 - 4.5 8.0 11.7 1.1 9.9 0.8 2.7 3 0 0 3 3 2 0 Mitochondrial protein Pet20 PDGF_N PF04692.13 CDI85027.1 - 4.7 8.1 16.5 1.7 9.4 3.4 2.7 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region RAB3GAP2_N PF14655.6 CDI85027.1 - 4.7 6.4 20.6 5.7 6.1 6.3 2.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus OATP PF03137.20 CDI85027.1 - 4.9 5.3 11.6 4.9 5.3 3.1 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family NPH3 PF03000.14 CDI85027.1 - 5.7 6.5 12.2 1.6 8.3 1.4 2.3 2 0 0 2 2 2 0 NPH3 family RNA_pol_Rbc25 PF08292.12 CDI85027.1 - 6.7 7.0 17.2 3.1 8.1 1.6 2.9 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 MAM33 PF02330.16 CDI85027.1 - 7.2 6.5 24.8 0.34 10.8 3.0 2.8 3 0 0 3 3 3 0 Mitochondrial glycoprotein ABC2_membrane_2 PF12679.7 CDI85027.1 - 8.5 5.6 11.2 4.4 6.5 2.3 2.4 2 0 0 2 2 2 0 ABC-2 family transporter protein Maf1 PF09174.10 CDI85027.1 - 8.7 6.5 12.1 12 6.0 1.1 2.4 2 0 0 2 2 2 0 Maf1 regulator RskA PF10099.9 CDI85028.1 - 8.2e-07 29.5 2.3 8.2e-07 29.5 2.3 3.2 1 1 2 3 3 3 1 Anti-sigma-K factor rskA Lin-8 PF03353.15 CDI85028.1 - 0.39 10.2 37.9 0.42 10.1 26.5 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF2973 PF11189.8 CDI85028.1 - 9.2 6.4 9.9 10 6.3 0.8 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) O-antigen_lig PF13425.6 CDI85028.1 - 9.3 4.9 7.5 12 4.6 7.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Ribosomal_60s PF00428.19 CDI85029.1 - 0.055 14.1 9.4 0.11 13.1 9.4 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein RIFIN PF02009.16 CDI85029.1 - 6.8 6.5 16.2 8.2 6.2 16.2 1.1 1 0 0 1 1 1 0 Rifin DUF572 PF04502.13 CDI85029.1 - 7.6 6.1 27.5 9 5.8 27.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SRP-alpha_N PF04086.13 CDI85029.1 - 8.1 6.3 28.5 9.4 6.1 28.5 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Tub_N PF16322.5 CDI85029.1 - 9.3 6.6 34.0 11 6.3 34.0 1.0 1 0 0 1 1 1 0 Tubby N-terminal DUF2722 PF10846.8 CDI85031.1 - 0.00061 18.9 3.3 0.00061 18.9 3.3 4.4 3 1 1 4 4 4 2 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI85032.1 - 0.047 14.3 26.9 0.49 11.1 26.9 2.0 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1387 PF07139.11 CDI85032.1 - 0.058 13.1 7.4 0.067 12.9 7.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF4179 PF13786.6 CDI85032.1 - 1.1 9.7 0.0 1.1 9.7 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) Endostatin PF06482.11 CDI85032.1 - 2.3 7.6 8.2 2.6 7.4 8.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Pneumo_att_G PF05539.11 CDI85032.1 - 2.5 7.6 23.4 3 7.4 23.4 1.0 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Presenilin PF01080.17 CDI85032.1 - 3.2 6.4 8.0 3.6 6.3 8.0 1.2 1 0 0 1 1 1 0 Presenilin Spem1 PF15670.5 CDI85032.1 - 3.4 7.2 6.9 2.7 7.5 5.8 1.3 1 1 0 1 1 1 0 Spermatid maturation protein 1 Apt1 PF10351.9 CDI85032.1 - 4.9 5.9 7.3 5.2 5.8 7.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF1788 PF08747.11 CDI85034.1 - 0.16 12.0 6.8 0.18 11.8 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1788) DUF3523 PF12037.8 CDI85035.1 - 0.096 12.1 53.1 0.18 11.2 53.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) RskA PF10099.9 CDI85036.1 - 5.2e-05 23.6 21.2 5.2e-05 23.6 21.2 4.7 1 1 2 3 3 3 1 Anti-sigma-K factor rskA DUF4776 PF16003.5 CDI85036.1 - 0.67 8.9 34.1 0.96 8.4 34.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) SART-1 PF03343.13 CDI85036.1 - 1.7 7.1 40.1 2.6 6.5 40.1 1.2 1 0 0 1 1 1 0 SART-1 family DUF572 PF04502.13 CDI85036.1 - 5.4 6.5 37.6 0.076 12.6 28.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) TFIIA PF03153.13 CDI85037.1 - 0.014 15.4 63.8 0.018 15.1 63.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI85037.1 - 0.48 8.9 64.5 0.68 8.4 64.5 1.3 1 0 0 1 1 1 0 Macoilin family Med3 PF11593.8 CDI85037.1 - 2.7 7.1 49.0 3.7 6.6 49.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Hamartin PF04388.12 CDI85037.1 - 8.9 4.8 52.0 15 4.1 52.0 1.3 1 0 0 1 1 1 0 Hamartin protein Spt20 PF12090.8 CDI85038.1 - 0.00011 21.9 22.6 0.00013 21.7 22.6 1.1 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI85038.1 - 0.00086 18.4 16.6 0.00092 18.3 16.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Tom22 PF04281.13 CDI85038.1 - 0.0088 15.8 4.1 0.01 15.6 4.1 1.2 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 MMR1 PF08505.10 CDI85038.1 - 0.011 16.1 12.0 0.011 16.0 12.0 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF3295 PF11702.8 CDI85038.1 - 0.033 13.6 15.2 0.035 13.5 15.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) NST1 PF13945.6 CDI85038.1 - 0.043 13.9 18.4 0.056 13.6 18.4 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF3464 PF11947.8 CDI85038.1 - 0.05 13.3 7.3 0.064 13.0 7.3 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Menin PF05053.13 CDI85038.1 - 0.06 11.7 11.9 0.066 11.6 11.9 1.1 1 0 0 1 1 1 0 Menin Sporozoite_P67 PF05642.11 CDI85038.1 - 0.065 11.3 8.3 0.071 11.2 8.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ANAPC_CDC26 PF10471.9 CDI85038.1 - 0.066 14.1 20.3 0.12 13.3 20.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 DUF4834 PF16118.5 CDI85038.1 - 0.068 14.1 10.7 0.094 13.7 10.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3402 PF11882.8 CDI85038.1 - 0.096 11.8 9.9 0.11 11.6 9.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) SpoIIP PF07454.11 CDI85038.1 - 0.11 12.0 10.6 0.12 11.8 10.6 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) EPL1 PF10513.9 CDI85038.1 - 0.11 12.9 10.7 0.13 12.7 10.7 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like CDRT4 PF15213.6 CDI85038.1 - 0.11 13.1 4.2 0.15 12.7 4.2 1.2 1 0 0 1 1 1 0 CMT1A duplicated region transcript 4 protein PRTP PF01366.18 CDI85038.1 - 0.12 10.4 5.4 0.12 10.4 5.4 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein DUF4657 PF15552.6 CDI85038.1 - 0.13 11.8 13.2 0.16 11.5 13.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4657) TERB2 PF15101.6 CDI85038.1 - 0.15 12.1 14.5 0.17 11.9 14.5 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Ctr PF04145.15 CDI85038.1 - 0.2 12.3 3.9 0.22 12.1 3.9 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Asp-B-Hydro_N PF05279.11 CDI85038.1 - 0.2 11.7 6.5 0.21 11.7 6.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region FAM176 PF14851.6 CDI85038.1 - 0.25 11.0 3.9 0.29 10.8 3.9 1.1 1 0 0 1 1 1 0 FAM176 family DUF702 PF05142.12 CDI85038.1 - 0.26 11.7 8.0 0.31 11.5 8.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF702) ATP11 PF06644.11 CDI85038.1 - 0.28 11.0 10.1 0.3 10.8 10.1 1.2 1 0 0 1 1 1 0 ATP11 protein CSRNP_N PF16019.5 CDI85038.1 - 0.3 11.0 7.3 0.35 10.8 7.3 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Macoilin PF09726.9 CDI85038.1 - 0.34 9.4 8.8 0.37 9.3 8.8 1.1 1 0 0 1 1 1 0 Macoilin family TFIIF_alpha PF05793.12 CDI85038.1 - 0.35 9.4 9.8 0.49 8.9 9.8 1.3 1 1 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Presenilin PF01080.17 CDI85038.1 - 0.36 9.6 11.1 0.35 9.6 11.1 1.1 1 0 0 1 1 1 0 Presenilin RLL PF10036.9 CDI85038.1 - 0.36 10.6 13.3 0.42 10.4 13.3 1.1 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein Lin-8 PF03353.15 CDI85038.1 - 0.38 10.3 13.0 0.38 10.3 13.0 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Folliculin PF11704.8 CDI85038.1 - 0.4 10.6 9.0 0.49 10.3 9.0 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Connexin PF00029.19 CDI85038.1 - 0.41 10.4 6.0 0.5 10.1 6.0 1.1 1 0 0 1 1 1 0 Connexin SLC12 PF03522.15 CDI85038.1 - 0.41 9.6 8.9 0.42 9.6 8.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF3276 PF11680.8 CDI85038.1 - 0.43 10.7 10.9 0.6 10.2 10.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) FAM150 PF15129.6 CDI85038.1 - 0.44 10.7 8.0 0.56 10.4 8.0 1.2 1 0 0 1 1 1 0 FAM150 family DUF4746 PF15928.5 CDI85038.1 - 0.46 9.9 7.0 0.49 9.8 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) UBN_AB PF14075.6 CDI85038.1 - 0.48 10.1 10.8 0.64 9.7 10.8 1.1 1 0 0 1 1 1 0 Ubinuclein conserved middle domain DDHD PF02862.17 CDI85038.1 - 0.53 10.4 9.0 0.5 10.5 9.0 1.1 1 0 0 1 1 1 0 DDHD domain Zip PF02535.22 CDI85038.1 - 0.6 9.3 4.3 0.66 9.1 4.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Mcm10 PF09332.11 CDI85038.1 - 0.61 9.5 12.5 0.59 9.5 12.5 1.0 1 0 0 1 1 1 0 Mcm10 replication factor eIF-3_zeta PF05091.12 CDI85038.1 - 0.65 8.9 11.3 0.71 8.8 11.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) F-protein PF00469.20 CDI85038.1 - 0.67 9.5 7.3 0.82 9.2 7.3 1.0 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef SID-1_RNA_chan PF13965.6 CDI85038.1 - 0.72 8.2 7.2 0.82 8.0 7.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Gti1_Pac2 PF09729.9 CDI85038.1 - 0.75 9.9 8.5 0.84 9.7 8.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family MPM1 PF17234.2 CDI85038.1 - 0.79 10.0 12.6 1 9.6 12.6 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 ALMT PF11744.8 CDI85038.1 - 0.83 8.4 8.6 0.87 8.3 8.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2572 PF10833.8 CDI85038.1 - 0.86 9.3 8.3 0.97 9.1 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) Band_3_cyto PF07565.13 CDI85038.1 - 1.1 9.0 9.8 1.2 8.8 9.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain XRN_M PF17846.1 CDI85038.1 - 1.1 8.1 8.3 1.2 8.0 8.3 1.0 1 0 0 1 1 1 0 Xrn1 helical domain OATP PF03137.20 CDI85038.1 - 1.2 7.3 3.8 1.4 7.1 3.8 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CPSF100_C PF13299.6 CDI85038.1 - 1.2 9.2 12.2 1.5 9.0 12.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FAM60A PF15396.6 CDI85038.1 - 1.4 8.9 7.9 1.5 8.8 7.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A MDM31_MDM32 PF08118.11 CDI85038.1 - 1.4 7.5 9.0 1.7 7.3 9.0 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Paf1 PF03985.13 CDI85038.1 - 1.5 7.7 15.0 1.8 7.5 15.0 1.0 1 0 0 1 1 1 0 Paf1 CLN3 PF02487.17 CDI85038.1 - 1.6 7.7 7.6 1.8 7.5 7.6 1.0 1 0 0 1 1 1 0 CLN3 protein Het-C PF07217.11 CDI85038.1 - 1.6 7.2 8.9 1.9 6.9 8.9 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C P5-ATPase PF12409.8 CDI85038.1 - 1.6 8.8 5.5 1.9 8.6 5.5 1.1 1 0 0 1 1 1 0 P5-type ATPase cation transporter Tim54 PF11711.8 CDI85038.1 - 1.8 7.3 9.8 1.8 7.2 9.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 UPF0560 PF10577.9 CDI85038.1 - 1.8 7.0 13.9 1.9 6.9 13.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Neur_chan_memb PF02932.16 CDI85038.1 - 1.9 8.5 6.4 1.9 8.5 6.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DNA_pol_delta_4 PF04081.13 CDI85038.1 - 2.1 8.7 10.0 2.8 8.3 10.0 1.2 1 0 0 1 1 1 0 DNA polymerase delta, subunit 4 TMEM51 PF15345.6 CDI85038.1 - 2.1 8.1 13.3 2.5 7.9 13.3 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 V_ATPase_I PF01496.19 CDI85038.1 - 2.3 6.0 10.2 2.6 5.9 10.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EOS1 PF12326.8 CDI85038.1 - 2.4 8.0 6.1 3 7.7 6.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein Peroxin-3 PF04882.12 CDI85038.1 - 2.7 6.9 15.0 2.9 6.8 15.0 1.0 1 0 0 1 1 1 0 Peroxin-3 Roughex PF06020.11 CDI85038.1 - 2.7 7.0 12.9 2.9 6.9 12.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Sec62 PF03839.16 CDI85038.1 - 3.2 7.2 6.0 3.6 7.0 6.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Ureide_permease PF07168.11 CDI85038.1 - 3.6 6.2 6.2 4.5 5.9 6.2 1.1 1 0 0 1 1 1 0 Ureide permease Hid1 PF12722.7 CDI85038.1 - 3.6 5.6 10.3 3.4 5.7 10.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1980 PF09323.10 CDI85038.1 - 3.8 7.4 7.3 4.5 7.1 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Ndc1_Nup PF09531.10 CDI85038.1 - 4.1 6.0 16.6 4.1 6.0 16.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Otopetrin PF03189.13 CDI85038.1 - 4.4 6.0 7.0 4.8 5.9 7.0 1.0 1 0 0 1 1 1 0 Otopetrin Pannexin_like PF12534.8 CDI85038.1 - 5.9 5.9 8.7 6.7 5.7 8.7 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF3533 PF12051.8 CDI85038.1 - 6.4 5.6 8.3 6.7 5.5 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) GREB1 PF15782.5 CDI85038.1 - 8.2 3.4 14.4 8.3 3.4 14.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Tau95_N PF17682.1 CDI85038.1 - 8.6 6.6 11.8 2.6 8.2 0.2 2.1 1 1 1 2 2 2 0 Tau95 Triple barrel domain HCO3_cotransp PF00955.21 CDI85038.1 - 8.7 5.0 5.6 9.3 4.9 5.6 1.0 1 0 0 1 1 1 0 HCO3- transporter family MRI PF15325.6 CDI85038.1 - 9.7 7.3 12.2 0.41 11.8 5.7 1.8 1 1 1 2 2 1 0 Modulator of retrovirus infection Gp5_C PF06715.12 CDI85040.1 - 0.026 14.7 44.6 3.6 7.9 0.1 10.7 3 3 9 14 14 14 0 Gp5 C-terminal repeat (3 copies) CD20 PF04103.15 CDI85040.1 - 1.3 9.1 4.1 2.4 8.3 4.1 1.3 1 0 0 1 1 1 0 CD20-like family Chordopox_G3 PF06129.12 CDI85040.1 - 5.2 7.8 18.1 17 6.2 0.7 3.9 1 1 2 3 3 3 0 Chordopoxvirus G3 protein Rrp44_CSD1 PF17216.3 CDI85040.1 - 8.5 6.1 23.4 0.95 9.2 1.8 4.3 1 1 3 4 4 4 0 Rrp44-like cold shock domain RR_TM4-6 PF06459.12 CDI85041.1 - 2.1 8.1 32.8 2.4 7.9 32.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CAC1F_C PF16885.5 CDI85041.1 - 2.3 7.8 26.6 2.3 7.8 26.6 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term DDRGK PF09756.9 CDI85041.1 - 2.5 7.6 36.8 3 7.4 36.8 1.2 1 0 0 1 1 1 0 DDRGK domain DUF4746 PF15928.5 CDI85041.1 - 2.8 7.3 20.4 3.3 7.1 20.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Endostatin PF06482.11 CDI85041.1 - 3.4 7.0 31.5 4.1 6.8 31.5 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin STAC2_u1 PF16664.5 CDI85041.1 - 4.1 7.9 22.6 6 7.3 22.6 1.3 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 DUF2126 PF09899.9 CDI85041.1 - 4.4 5.3 19.9 4.2 5.3 19.9 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Sec62 PF03839.16 CDI85041.1 - 5.4 6.5 24.6 6.7 6.2 24.6 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2828 PF11443.8 CDI85041.1 - 6.5 4.7 28.0 6.9 4.6 28.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4407 PF14362.6 CDI85041.1 - 6.8 5.9 32.3 7.4 5.8 32.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NPR3 PF03666.13 CDI85041.1 - 7.6 5.2 35.4 8.6 5.0 35.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 V_ATPase_I PF01496.19 CDI85041.1 - 9.1 4.0 31.4 11 3.8 31.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF936 PF06075.12 CDI85042.1 - 7.6 5.3 49.7 9.6 5.0 49.7 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) TFIIF_alpha PF05793.12 CDI85043.1 - 0.0054 15.4 27.8 0.0066 15.1 27.8 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2457 PF10446.9 CDI85043.1 - 0.0071 15.5 29.2 0.0091 15.2 29.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) CDC45 PF02724.14 CDI85043.1 - 0.0076 14.6 18.1 0.0088 14.4 18.1 1.2 1 0 0 1 1 1 1 CDC45-like protein BUD22 PF09073.10 CDI85043.1 - 0.0099 15.3 30.4 0.012 15.0 30.4 1.1 1 0 0 1 1 1 1 BUD22 BSP_II PF05432.11 CDI85043.1 - 0.035 13.8 28.5 0.046 13.4 28.5 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Utp14 PF04615.13 CDI85043.1 - 0.14 10.8 16.8 0.15 10.6 16.8 1.1 1 0 0 1 1 1 0 Utp14 protein Peptidase_S64 PF08192.11 CDI85043.1 - 0.33 9.4 11.3 0.39 9.1 11.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 Mpp10 PF04006.12 CDI85043.1 - 0.44 8.9 29.4 0.58 8.5 29.4 1.1 1 0 0 1 1 1 0 Mpp10 protein Apt1 PF10351.9 CDI85043.1 - 0.85 8.4 13.3 1 8.1 13.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Nop14 PF04147.12 CDI85043.1 - 0.94 7.6 29.2 1.1 7.3 29.2 1.1 1 0 0 1 1 1 0 Nop14-like family Lin-8 PF03353.15 CDI85043.1 - 2.1 7.8 17.8 2.7 7.5 17.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RR_TM4-6 PF06459.12 CDI85043.1 - 6.4 6.5 18.7 10 5.9 18.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paf1 PF03985.13 CDI85043.1 - 8.5 5.3 32.8 14 4.5 32.8 1.4 1 0 0 1 1 1 0 Paf1 TMEM154 PF15102.6 CDI85045.1 - 0.0082 16.0 10.0 0.0082 16.0 10.0 1.8 1 1 1 2 2 2 1 TMEM154 protein family DUF4366 PF14283.6 CDI85045.1 - 0.016 15.3 1.5 0.02 14.9 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Spc7_N PF15402.6 CDI85045.1 - 0.024 12.9 13.7 0.029 12.7 13.7 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 RIFIN PF02009.16 CDI85045.1 - 0.029 14.3 7.1 0.039 13.8 7.1 1.1 1 0 0 1 1 1 0 Rifin IHABP4_N PF16174.5 CDI85045.1 - 0.041 14.5 1.7 0.051 14.2 1.7 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal MID_MedPIWI PF18296.1 CDI85045.1 - 0.18 11.6 8.9 0.22 11.3 8.9 1.1 1 0 0 1 1 1 0 MID domain of medPIWI Plasmodium_Vir PF05795.11 CDI85045.1 - 0.22 10.9 7.1 0.27 10.6 7.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Ribosomal_60s PF00428.19 CDI85045.1 - 0.63 10.7 7.9 0.99 10.0 7.9 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein CPSF100_C PF13299.6 CDI85045.1 - 0.82 9.8 4.2 1 9.6 4.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 CDI85045.1 - 1.2 7.8 6.4 1.5 7.5 6.4 1.2 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI85045.1 - 1.3 8.9 11.3 1.6 8.6 11.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Kei1 PF08552.11 CDI85045.1 - 2.1 8.2 11.5 1.7 8.5 10.6 1.3 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Macoilin PF09726.9 CDI85045.1 - 3.7 6.0 14.8 5.3 5.5 14.8 1.2 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 CDI85045.1 - 4.6 7.0 12.2 6 6.7 12.2 1.1 1 0 0 1 1 1 0 SPX domain SR-25 PF10500.9 CDI85045.1 - 6 6.4 30.8 0.61 9.7 11.5 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein PepSY_2 PF13670.6 CDI85045.1 - 7.3 6.7 9.0 30 4.7 9.0 2.0 2 1 1 3 3 3 0 Peptidase propeptide and YPEB domain DUF4400 PF14348.6 CDI85045.1 - 8.6 5.8 10.1 1.6 8.2 6.4 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4400) GCOM2 PF15328.6 CDI85045.1 - 9.8 6.5 11.1 13 6.1 11.1 1.2 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 DUF755 PF05501.11 CDI85047.1 - 0.011 16.0 28.7 0.011 16.0 28.7 4.3 3 1 1 4 4 4 0 Domain of unknown function (DUF755) FAM150 PF15129.6 CDI85047.1 - 9.4 6.4 31.6 3 8.0 8.9 3.8 2 1 2 4 4 4 0 FAM150 family Apt1 PF10351.9 CDI85048.1 - 1.1 8.1 24.1 0.0077 15.1 10.4 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain CLN3 PF02487.17 CDI85048.1 - 2.9 6.8 9.6 2 7.3 3.3 2.4 2 0 0 2 2 2 0 CLN3 protein ERM PF00769.19 CDI85049.1 - 0.00099 19.0 16.8 0.00099 19.0 16.8 6.7 5 2 1 6 6 6 1 Ezrin/radixin/moesin family G-patch PF01585.23 CDI85049.1 - 0.0044 16.9 0.4 0.01 15.7 0.4 1.6 1 0 0 1 1 1 1 G-patch domain SR-25 PF10500.9 CDI85049.1 - 0.0072 16.0 14.5 0.0072 16.0 14.5 9.4 4 3 4 8 8 8 1 Nuclear RNA-splicing-associated protein zf-CCCH PF00642.24 CDI85049.1 - 0.011 15.6 4.0 0.027 14.4 4.0 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF4179 PF13786.6 CDI85049.1 - 0.18 12.3 27.2 1.5 9.4 0.0 6.5 5 1 1 6 6 6 0 Domain of unknown function (DUF4179) RRM_1 PF00076.22 CDI85050.1 - 1.8e-18 66.1 0.0 3.2e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUIM_assoc PF16619.5 CDI85050.1 - 0.00057 19.9 9.0 0.00057 19.9 9.0 5.7 3 3 0 3 3 1 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI85050.1 - 0.0012 18.5 10.4 0.0012 18.5 10.4 3.1 2 1 1 3 3 2 1 Spt20 family GET2 PF08690.10 CDI85050.1 - 0.004 16.9 11.4 0.004 16.9 11.4 2.7 3 0 0 3 3 3 1 GET complex subunit GET2 SR-25 PF10500.9 CDI85050.1 - 0.022 14.4 41.6 0.017 14.7 16.5 3.1 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein RRM_7 PF16367.5 CDI85050.1 - 0.042 14.0 0.0 0.042 14.0 0.0 2.4 3 1 1 4 4 4 0 RNA recognition motif Nup35_RRM_2 PF14605.6 CDI85050.1 - 0.17 11.9 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif FAM60A PF15396.6 CDI85050.1 - 0.66 9.9 23.0 0.21 11.6 9.6 3.0 3 0 0 3 3 3 0 Protein Family FAM60A SLC12 PF03522.15 CDI85050.1 - 1.7 7.6 25.3 0.29 10.1 13.7 2.1 2 0 0 2 2 2 0 Solute carrier family 12 CCSAP PF15748.5 CDI85050.1 - 1.8 8.7 42.7 1.8 8.7 13.5 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DUF2126 PF09899.9 CDI85050.1 - 1.8 6.6 12.8 2.4 6.1 0.6 2.4 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) DUF4148 PF13663.6 CDI85051.1 - 0.027 14.7 0.1 0.027 14.7 0.1 5.2 5 2 0 5 5 5 0 Domain of unknown function (DUF4148) SET_assoc PF11767.8 CDI85053.1 - 0.0027 17.3 0.0 0.0033 17.0 0.0 1.1 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated Chorein_N PF12624.7 CDI85053.1 - 0.053 13.6 4.0 0.072 13.2 4.0 1.2 1 1 0 1 1 1 0 N-terminal region of Chorein or VPS13 OmpH PF03938.14 CDI85053.1 - 0.4 11.0 19.2 0.47 10.8 19.2 1.0 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TFIIA PF03153.13 CDI85053.1 - 8.8 6.2 22.6 9.6 6.1 22.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MRI PF15325.6 CDI85054.1 - 0.021 15.9 13.2 0.021 15.9 13.2 4.1 2 1 1 3 3 3 0 Modulator of retrovirus infection CDC27 PF09507.10 CDI85054.1 - 0.023 14.1 57.7 0.034 13.5 57.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RskA PF10099.9 CDI85055.1 - 1.1e-06 29.1 16.7 0.023 15.0 16.7 2.6 1 1 0 1 1 1 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI85055.1 - 0.0025 17.9 67.8 0.003 17.6 67.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CDC27 PF09507.10 CDI85055.1 - 0.037 13.4 38.5 0.047 13.1 38.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 AAA_23 PF13476.6 CDI85055.1 - 0.28 11.6 28.4 0.43 11.1 28.4 1.3 1 0 0 1 1 1 0 AAA domain PAT1 PF09770.9 CDI85055.1 - 0.35 9.1 46.2 0.46 8.7 46.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med19 PF10278.9 CDI85055.1 - 0.37 10.7 16.9 0.6 10.0 16.9 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 PPP4R2 PF09184.11 CDI85055.1 - 0.55 9.8 29.8 0.71 9.4 29.8 1.3 1 0 0 1 1 1 0 PPP4R2 Utp14 PF04615.13 CDI85055.1 - 0.93 8.0 41.8 1.2 7.6 41.8 1.0 1 0 0 1 1 1 0 Utp14 protein UPF0564 PF10595.9 CDI85055.1 - 1.9 7.5 44.4 2.5 7.0 44.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 eIF3_subunit PF08597.10 CDI85055.1 - 2.1 8.2 34.4 0.33 10.8 26.5 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit CDK5_activator PF03261.15 CDI85055.1 - 9.5 5.6 33.9 11 5.5 33.9 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF747 PF05346.11 CDI85056.1 - 1.2e-26 94.0 0.0 1.2e-26 94.0 0.0 3.5 4 0 0 4 4 4 1 Eukaryotic membrane protein family Mucin PF01456.17 CDI85056.1 - 9.5e-06 25.7 6.3 9.5e-06 25.7 6.3 14.1 9 6 3 12 12 12 1 Mucin-like glycoprotein DUF4834 PF16118.5 CDI85056.1 - 0.00022 22.1 0.5 0.00022 22.1 0.5 21.0 13 6 5 19 19 19 1 Domain of unknown function (DUF4834) Tim54 PF11711.8 CDI85056.1 - 0.00081 18.3 9.6 0.00081 18.3 9.6 12.6 8 4 2 11 11 11 2 Inner membrane protein import complex subunit Tim54 Spt20 PF12090.8 CDI85056.1 - 0.0011 18.6 9.0 0.0011 18.6 9.0 19.5 12 6 5 17 17 17 5 Spt20 family FPN1 PF06963.12 CDI85056.1 - 0.0013 17.4 0.6 0.0013 17.4 0.6 10.6 9 2 0 10 10 10 1 Ferroportin1 (FPN1) Connexin PF00029.19 CDI85056.1 - 0.0057 16.4 2.9 0.0057 16.4 2.9 14.1 11 5 0 12 12 12 2 Connexin DUF4407 PF14362.6 CDI85056.1 - 0.033 13.6 0.1 0.033 13.6 0.1 12.3 5 2 5 10 10 10 0 Domain of unknown function (DUF4407) Spt20 PF12090.8 CDI85057.1 - 0.0041 16.8 8.7 0.0041 16.8 8.7 8.5 7 1 1 8 8 8 5 Spt20 family RPAP2_Rtr1 PF04181.13 CDI85057.1 - 0.059 13.7 0.5 0.059 13.7 0.5 3.7 5 0 0 5 5 5 0 Rtr1/RPAP2 family RVT_1 PF00078.27 CDI85059.1 - 4e-12 46.1 0.0 5.9e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 CDI85059.1 - 0.0099 16.6 0.2 0.032 15.1 0.2 1.9 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_9 PF16293.5 CDI85059.1 - 0.063 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) Helicase_C PF00271.31 CDI85060.1 - 5.8e-13 49.2 0.0 1.4e-12 47.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Activator_LAG-3 PF11498.8 CDI85061.1 - 0.052 12.5 37.5 0.0089 15.0 27.7 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 MCU PF04678.13 CDI85061.1 - 1.7 8.7 6.5 1.2 9.3 4.4 1.8 2 0 0 2 2 2 0 Mitochondrial calcium uniporter FAM60A PF15396.6 CDI85061.1 - 3.7 7.5 14.1 10 6.1 7.0 2.2 2 0 0 2 2 2 0 Protein Family FAM60A DUF2722 PF10846.8 CDI85062.1 - 0.034 13.1 9.4 0.06 12.3 9.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Med15 PF09606.10 CDI85062.1 - 0.13 11.0 41.4 0.16 10.6 41.4 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI85062.1 - 1 9.2 42.4 3 7.7 42.6 1.6 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI85063.1 - 0.00097 18.2 3.0 0.00097 18.2 3.0 13.2 8 4 2 11 11 11 5 Protein of unknown function (DUF2722) COPI_assoc PF08507.10 CDI85064.1 - 1.5e-07 31.5 1.9 2.3e-07 30.9 1.9 1.2 1 0 0 1 1 1 1 COPI associated protein Neurensin PF14927.6 CDI85064.1 - 0.019 14.7 0.0 0.019 14.7 0.0 1.9 3 0 0 3 3 3 0 Neurensin G-patch PF01585.23 CDI85066.1 - 2.2e-14 53.1 1.1 2.2e-14 53.1 1.1 1.8 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 CDI85066.1 - 0.00034 20.6 0.4 0.0011 19.0 0.4 1.8 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 CDI85066.1 - 0.0043 16.8 0.0 0.0085 15.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CBP4 PF07960.11 CDI85066.1 - 0.032 14.1 0.3 0.075 12.9 0.3 1.6 1 0 0 1 1 1 0 CBP4 AAA_12 PF13087.6 CDI85067.1 - 6.4e-52 176.1 0.0 1.1e-51 175.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CDI85067.1 - 6.4e-44 150.7 3.6 1.6e-26 93.6 0.0 2.9 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 CDI85067.1 - 2.8e-11 43.5 0.0 1.2e-10 41.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDI85067.1 - 1.4e-09 38.5 0.0 5.4e-09 36.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain PIF1 PF05970.14 CDI85067.1 - 6.5e-05 22.3 0.0 0.0063 15.7 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase DUF2075 PF09848.9 CDI85067.1 - 0.00036 19.9 0.2 0.062 12.5 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 CDI85067.1 - 0.0011 18.9 0.0 0.0031 17.5 0.0 1.8 1 0 0 1 1 1 1 NACHT domain dsrm PF00035.26 CDI85067.1 - 0.0015 19.2 0.3 0.48 11.2 0.0 3.1 3 0 0 3 3 2 1 Double-stranded RNA binding motif PhoH PF02562.16 CDI85067.1 - 0.0021 17.5 0.0 0.014 14.8 0.0 2.1 2 0 0 2 2 2 1 PhoH-like protein ResIII PF04851.15 CDI85067.1 - 0.0023 17.9 0.0 0.0057 16.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit IstB_IS21 PF01695.17 CDI85067.1 - 0.01 15.6 0.0 0.025 14.3 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Viral_helicase1 PF01443.18 CDI85067.1 - 0.013 15.2 0.0 1.6 8.4 0.0 3.1 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA PF00004.29 CDI85067.1 - 0.025 15.0 0.0 0.085 13.3 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) UvrD-helicase PF00580.21 CDI85067.1 - 0.04 13.5 0.6 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain DEAD PF00270.29 CDI85067.1 - 0.058 13.1 0.1 0.19 11.5 0.0 1.9 2 0 0 2 2 2 0 DEAD/DEAH box helicase Sigma54_activat PF00158.26 CDI85067.1 - 0.065 12.9 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 CDI85067.1 - 0.081 12.3 0.1 0.24 10.7 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 CDI85067.1 - 0.085 13.2 0.0 0.28 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain DSPc PF00782.20 CDI85068.1 - 8.9e-21 74.1 0.0 1.2e-16 60.7 0.1 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDI85068.1 - 0.017 14.7 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Suf PF05843.14 CDI85068.1 - 3.2 7.7 7.9 2.5 8.0 2.4 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) CCDC53 PF10152.9 CDI85068.1 - 9.1 6.7 11.1 3.3 8.1 4.1 3.1 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex eIF3_p135 PF12807.7 CDI85070.1 - 0.00021 21.4 0.0 0.00045 20.3 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 MORN PF02493.20 CDI85071.1 - 2.3e-27 93.2 49.2 0.00012 21.8 0.5 10.8 10 0 0 10 10 10 8 MORN repeat Avl9 PF09794.9 CDI85071.1 - 8.4e-15 54.3 0.0 4.5e-13 48.7 0.0 2.2 1 1 1 2 2 2 2 Transport protein Avl9 DENN PF02141.21 CDI85071.1 - 0.0026 17.7 0.3 0.005 16.8 0.3 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain DUF2347 PF09804.9 CDI85071.1 - 0.17 11.4 0.2 0.37 10.3 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 CDI85071.1 - 0.19 11.7 0.1 0.37 10.7 0.1 1.4 1 0 0 1 1 1 0 Stabilization of polarity axis RAMP4 PF06624.12 CDI85072.1 - 4.3e-22 77.9 0.4 5.3e-22 77.6 0.4 1.1 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Choline_transpo PF04515.12 CDI85073.1 - 3.1e-33 115.4 29.5 1.7e-30 106.4 5.1 3.5 3 1 1 4 4 4 2 Plasma-membrane choline transporter MCM_OB PF17207.3 CDI85074.1 - 0.0016 18.3 7.3 0.0035 17.2 7.2 1.7 1 1 0 1 1 1 1 MCM OB domain TFIIA PF03153.13 CDI85074.1 - 0.0055 16.8 17.2 0.0055 16.8 17.2 2.0 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI85074.1 - 0.0061 15.6 11.1 0.0061 15.6 11.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) PSCyt3 PF07627.11 CDI85074.1 - 0.13 12.5 4.4 1.2 9.5 3.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1588) Suf PF05843.14 CDI85074.1 - 0.36 10.8 7.4 0.9 9.5 7.4 1.6 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Rxt3 PF08642.10 CDI85074.1 - 0.38 11.5 3.3 1 10.1 3.3 1.6 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Activator_LAG-3 PF11498.8 CDI85074.1 - 0.98 8.3 32.1 1.8 7.5 32.1 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Presenilin PF01080.17 CDI85074.1 - 1.1 7.9 4.7 1.5 7.5 4.7 1.3 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CDI85074.1 - 1.5 9.8 6.5 4.7 8.2 6.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI85074.1 - 3.8 7.1 25.1 7 6.2 25.1 1.4 1 0 0 1 1 1 0 Spt20 family Ribosomal_60s PF00428.19 CDI85074.1 - 7 7.3 22.8 3.7 8.2 3.6 2.8 2 1 1 3 3 3 0 60s Acidic ribosomal protein Ketoacyl-synt_C PF02801.22 CDI85076.1 - 2.4e-15 56.6 4.6 6.1e-12 45.6 0.5 5.7 5 0 0 5 5 5 2 Beta-ketoacyl synthase, C-terminal domain RskA PF10099.9 CDI85076.1 - 5.1e-06 26.9 10.2 0.00077 19.8 17.1 15.8 5 2 8 13 13 13 5 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI85076.1 - 0.00017 21.3 9.6 0.00017 21.3 9.6 12.8 13 2 0 13 13 13 4 Nuclear RNA-splicing-associated protein Med15 PF09606.10 CDI85076.1 - 0.0002 20.2 21.9 0.0002 20.2 21.9 9.1 6 3 1 7 7 7 3 ARC105 or Med15 subunit of Mediator complex non-fungal Yip1 PF04893.17 CDI85076.1 - 0.39 10.4 0.0 0.39 10.4 0.0 3.7 5 0 0 5 5 5 0 Yip1 domain DUF429 PF04250.13 CDI85078.1 - 2.1 8.1 10.7 0.21 11.4 5.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF429) Presenilin PF01080.17 CDI85078.1 - 3.8 6.2 35.1 4.3 6.0 35.1 1.0 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI85078.1 - 9.8 6.1 19.4 13 5.7 19.4 1.3 1 0 0 1 1 1 0 Protein Family FAM60A DUF2722 PF10846.8 CDI85079.1 - 0.0002 20.5 9.1 0.0002 20.5 9.1 2.3 2 0 0 2 2 1 1 Protein of unknown function (DUF2722) MID_MedPIWI PF18296.1 CDI85079.1 - 0.0052 16.6 15.0 0.081 12.7 9.5 2.2 2 0 0 2 2 2 2 MID domain of medPIWI Neur_chan_memb PF02932.16 CDI85079.1 - 0.0093 16.1 9.1 0.13 12.3 3.5 2.2 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region Zn_peptidase PF04228.13 CDI85079.1 - 0.011 15.3 2.4 0.011 15.3 2.4 2.5 2 1 0 2 2 1 0 Putative neutral zinc metallopeptidase PAT1 PF09770.9 CDI85079.1 - 0.011 14.1 25.1 0.095 11.0 3.9 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 TCP PF03634.13 CDI85079.1 - 0.012 16.2 15.1 0.37 11.4 9.1 2.3 2 0 0 2 2 2 0 TCP family transcription factor RskA PF10099.9 CDI85079.1 - 0.012 15.9 52.1 0.038 14.3 12.5 3.6 2 2 0 3 3 3 0 Anti-sigma-K factor rskA DDHD PF02862.17 CDI85079.1 - 0.013 15.7 14.9 1 9.5 0.2 2.2 2 0 0 2 2 2 0 DDHD domain Spt20 PF12090.8 CDI85079.1 - 0.014 15.0 19.3 0.014 15.0 19.3 2.4 2 0 0 2 2 2 0 Spt20 family DUF4834 PF16118.5 CDI85079.1 - 0.023 15.6 25.9 0.23 12.5 5.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) MecA PF05389.12 CDI85079.1 - 0.024 14.3 12.0 0.43 10.2 0.3 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) CPSF100_C PF13299.6 CDI85079.1 - 0.046 13.9 13.1 1.5 8.9 7.5 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal PIP5K PF01504.18 CDI85079.1 - 0.069 12.4 14.1 0.36 10.0 0.0 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase BPD_transp_2 PF02653.16 CDI85079.1 - 0.072 12.2 4.0 0.42 9.7 0.1 2.6 2 1 0 2 2 2 0 Branched-chain amino acid transport system / permease component GET2 PF08690.10 CDI85079.1 - 0.08 12.6 23.9 0.29 10.8 4.4 2.1 2 0 0 2 2 2 0 GET complex subunit GET2 Myc_N PF01056.18 CDI85079.1 - 0.14 12.0 11.7 0.048 13.6 6.9 2.1 2 0 0 2 2 2 0 Myc amino-terminal region CAF1 PF04857.20 CDI85079.1 - 0.2 10.8 6.5 4.4 6.4 0.0 2.1 2 0 0 2 2 2 0 CAF1 family ribonuclease RR_TM4-6 PF06459.12 CDI85079.1 - 0.25 11.1 20.5 0.12 12.2 8.6 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF1980 PF09323.10 CDI85079.1 - 0.42 10.5 15.0 1 9.2 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) CLN3 PF02487.17 CDI85079.1 - 0.44 9.5 13.0 3.1 6.8 0.3 2.2 2 0 0 2 2 2 0 CLN3 protein RIC3 PF15361.6 CDI85079.1 - 0.58 10.5 12.8 0.35 11.2 0.8 2.4 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 Suf PF05843.14 CDI85079.1 - 0.61 10.0 28.6 0.66 9.9 8.7 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Dpy19 PF10034.9 CDI85079.1 - 0.82 7.8 3.3 1.5 6.9 0.1 2.0 2 0 0 2 2 2 0 Q-cell neuroblast polarisation SID-1_RNA_chan PF13965.6 CDI85079.1 - 0.83 8.0 6.7 0.26 9.7 0.7 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Peroxin-13_N PF04088.13 CDI85079.1 - 0.99 9.7 9.9 4.5 7.6 0.5 2.5 2 0 0 2 2 2 0 Peroxin 13, N-terminal region SpoIIP PF07454.11 CDI85079.1 - 1.3 8.4 22.9 1.9 7.9 2.0 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) EIF4E-T PF10477.9 CDI85079.1 - 1.5 7.5 26.5 1.8 7.3 11.3 2.0 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E TRAP_alpha PF03896.16 CDI85079.1 - 1.8 7.7 11.4 3.2 6.9 8.0 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit VIR_N PF15912.5 CDI85079.1 - 2.2 7.8 11.0 11 5.5 8.9 2.1 2 0 0 2 2 2 0 Virilizer, N-terminal PA26 PF04636.13 CDI85079.1 - 2.3 7.0 15.5 2.1 7.2 6.6 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) DUF4820 PF16091.5 CDI85079.1 - 2.4 7.5 20.4 2.2 7.6 8.8 2.4 3 0 0 3 3 2 0 Domain of unknown function (DUF4820) FAM176 PF14851.6 CDI85079.1 - 2.5 7.8 14.8 9 6.0 0.2 2.4 2 0 0 2 2 2 0 FAM176 family Gti1_Pac2 PF09729.9 CDI85079.1 - 2.5 8.1 17.8 1.5 8.9 0.0 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family Rtf2 PF04641.12 CDI85079.1 - 2.6 7.3 17.9 3.2 7.1 0.2 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger Folate_carrier PF01770.18 CDI85079.1 - 2.9 6.5 11.6 4.5 5.9 4.8 2.1 2 0 0 2 2 2 0 Reduced folate carrier AUX_IAA PF02309.16 CDI85079.1 - 2.9 7.7 10.3 8.8 6.1 0.1 2.2 2 0 0 2 2 2 0 AUX/IAA family Serinc PF03348.15 CDI85079.1 - 3.5 6.4 11.8 1.9 7.3 5.1 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) Band_3_cyto PF07565.13 CDI85079.1 - 3.6 7.3 21.0 2.4 7.9 1.0 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF4484 PF14831.6 CDI85079.1 - 4 7.4 14.6 9.2 6.2 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) DUF4746 PF15928.5 CDI85079.1 - 4.8 6.5 17.8 1.7 8.0 9.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) ORC5_C PF14630.6 CDI85079.1 - 5 6.6 12.6 1.8 8.0 2.1 2.3 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus Arabinose_trans PF04602.12 CDI85079.1 - 6.7 5.4 8.3 0.11 11.3 0.9 1.7 2 0 0 2 2 2 0 Mycobacterial cell wall arabinan synthesis protein Presenilin PF01080.17 CDI85079.1 - 6.7 5.4 28.0 0.55 8.9 0.4 2.3 2 0 0 2 2 2 0 Presenilin RNA_pol_Rpc4 PF05132.14 CDI85079.1 - 7.2 7.0 21.0 4.1 7.8 9.4 2.8 3 0 0 3 3 2 0 RNA polymerase III RPC4 AIF_C PF14721.6 CDI85079.1 - 8.1 6.8 17.3 2.3 8.6 5.9 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term V_ATPase_I PF01496.19 CDI85079.1 - 8.1 4.2 22.0 1.8 6.4 1.0 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Baculo_PP31 PF05311.11 CDI85079.1 - 8.2 5.8 17.6 0.66 9.4 5.6 2.1 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) SLC12 PF03522.15 CDI85079.1 - 9.9 5.1 21.9 1.1 8.2 1.0 2.1 2 0 0 2 2 2 0 Solute carrier family 12 GvpL_GvpF PF06386.11 CDI85080.1 - 0.013 15.5 11.3 0.013 15.4 11.3 1.0 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF IF-2B PF01008.17 CDI85080.1 - 0.044 13.0 4.1 0.048 12.9 4.1 1.0 1 0 0 1 1 1 0 Initiation factor 2 subunit family FPN1 PF06963.12 CDI85080.1 - 0.093 11.3 8.0 0.097 11.2 8.0 1.0 1 0 0 1 1 1 0 Ferroportin1 (FPN1) DUF3029 PF11230.8 CDI85080.1 - 0.12 10.7 4.6 0.13 10.6 4.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3029) OATP PF03137.20 CDI85080.1 - 0.48 8.7 5.3 0.52 8.5 5.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Orf78 PF06024.12 CDI85080.1 - 0.49 10.7 4.7 0.57 10.5 4.7 1.1 1 0 0 1 1 1 0 Orf78 (ac78) PP_kinase_N PF13089.6 CDI85080.1 - 0.8 10.1 12.9 0.94 9.8 12.9 1.1 1 0 0 1 1 1 0 Polyphosphate kinase N-terminal domain Hexokinase_2 PF03727.16 CDI85080.1 - 1 8.7 3.7 1.1 8.7 3.7 1.0 1 0 0 1 1 1 0 Hexokinase Spore_III_AF PF09581.10 CDI85080.1 - 1.2 9.2 11.1 1.4 8.9 11.1 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) ORC_WH_C PF18137.1 CDI85080.1 - 1.4 9.0 9.6 1.6 8.8 9.6 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal LSDAT_euk PF18139.1 CDI85080.1 - 1.6 8.1 9.8 1.9 7.8 9.8 1.1 1 0 0 1 1 1 0 SLOG in TRPM CSG2 PF16965.5 CDI85080.1 - 1.7 7.5 5.9 1.7 7.5 5.9 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator PepSY_TM_like_2 PF16357.5 CDI85080.1 - 2 8.3 10.0 2.3 8.2 10.0 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like CemA PF03040.14 CDI85080.1 - 2.1 8.2 7.1 2.2 8.1 7.1 1.0 1 0 0 1 1 1 0 CemA family Presenilin PF01080.17 CDI85080.1 - 2.5 6.8 9.3 2.6 6.7 9.3 1.0 1 0 0 1 1 1 0 Presenilin DcuA_DcuB PF03605.14 CDI85080.1 - 2.6 6.8 3.8 3 6.6 3.8 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter EIIBC-GUT_N PF03612.14 CDI85080.1 - 2.7 7.7 8.0 2.8 7.6 8.0 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Ufd2P_core PF10408.9 CDI85080.1 - 2.8 6.4 18.1 3.2 6.2 18.1 1.0 1 0 0 1 1 1 0 Ubiquitin elongating factor core FapA PF03961.13 CDI85080.1 - 3.2 6.3 11.0 3.1 6.3 11.0 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF3464 PF11947.8 CDI85080.1 - 4.4 7.0 7.9 5.2 6.8 7.9 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 RBM39linker PF15519.6 CDI85080.1 - 4.6 8.4 11.1 5.6 8.1 11.1 1.1 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein Glt_symporter PF03616.14 CDI85080.1 - 4.7 5.8 5.6 5.1 5.7 5.6 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter TERB2 PF15101.6 CDI85080.1 - 4.7 7.2 18.1 5.3 7.0 18.1 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4199 PF13858.6 CDI85080.1 - 5 7.5 8.2 6.8 7.1 8.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Pex14_N PF04695.13 CDI85080.1 - 5 7.8 18.8 5.2 7.7 18.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CLN3 PF02487.17 CDI85080.1 - 5.2 6.0 8.7 5.6 5.9 8.7 1.0 1 0 0 1 1 1 0 CLN3 protein Neur_chan_memb PF02932.16 CDI85080.1 - 5.2 7.1 9.2 5.8 6.9 9.2 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HemX PF04375.14 CDI85080.1 - 8.7 5.5 31.0 9.1 5.5 31.0 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase RskA PF10099.9 CDI85081.1 - 0.00077 19.8 16.1 0.0012 19.1 16.1 1.4 1 0 0 1 1 1 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI85081.1 - 0.027 14.5 33.1 0.033 14.2 33.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hydin_ADK PF17213.3 CDI85081.1 - 0.3 11.4 11.0 0.42 10.9 11.0 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Spt20 PF12090.8 CDI85081.1 - 0.33 10.5 35.2 0.53 9.9 35.2 1.3 1 0 0 1 1 1 0 Spt20 family EOS1 PF12326.8 CDI85081.1 - 0.44 10.5 2.2 0.41 10.6 2.2 1.2 1 0 0 1 1 1 0 N-glycosylation protein DUF5427 PF10310.9 CDI85081.1 - 0.73 8.7 15.4 0.74 8.7 15.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Serinc PF03348.15 CDI85081.1 - 1 8.2 3.1 1.1 8.2 3.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RR_TM4-6 PF06459.12 CDI85081.1 - 1.1 9.0 10.0 1.3 8.8 10.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GREB1 PF15782.5 CDI85081.1 - 1.8 5.6 11.7 1.7 5.6 11.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4407 PF14362.6 CDI85081.1 - 2.1 7.6 13.0 2.5 7.4 13.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Presenilin PF01080.17 CDI85081.1 - 2.9 6.6 16.9 4 6.1 16.9 1.2 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 CDI85081.1 - 4.8 6.0 17.7 6.1 5.7 17.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spore_coat_CotO PF14153.6 CDI85081.1 - 5.6 6.9 23.0 7.7 6.4 23.0 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Hamartin PF04388.12 CDI85081.1 - 6.8 5.2 15.1 7 5.2 15.1 1.1 1 0 0 1 1 1 0 Hamartin protein Gemini_AC4_5_2 PF08464.10 CDI85082.1 - 0.16 12.0 0.1 0.29 11.1 0.1 1.4 1 0 0 1 1 1 0 Geminivirus AC4/5 conserved region Adaptin_binding PF10199.9 CDI85082.1 - 0.37 11.4 0.0 0.37 11.4 0.0 8.8 3 3 1 4 4 4 0 Alpha and gamma adaptin binding protein p34 TCRP1 PF14944.6 CDI85082.1 - 3.4 7.6 13.3 0.38 10.7 2.4 3.5 2 1 1 3 3 3 0 Tongue Cancer Chemotherapy Resistant Protein 1 DUF2722 PF10846.8 CDI85083.1 - 0.00073 18.6 3.7 0.00073 18.6 3.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) GET2 PF08690.10 CDI85083.1 - 0.021 14.5 6.7 0.024 14.3 6.7 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 GRP PF07172.11 CDI85083.1 - 0.24 12.1 5.7 0.34 11.6 5.7 1.3 1 0 0 1 1 1 0 Glycine rich protein family TFIIA PF03153.13 CDI85083.1 - 1.2 9.0 15.7 1.3 8.9 15.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EIF4E-T PF10477.9 CDI85083.1 - 1.9 7.2 8.8 1.9 7.3 8.8 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF2802 PF10975.8 CDI85083.1 - 2.2 8.5 14.4 3.3 7.9 14.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) PhnG PF06754.12 CDI85083.1 - 3.3 7.7 7.6 5 7.1 7.6 1.2 1 0 0 1 1 1 0 Phosphonate metabolism protein PhnG FAM222A PF15258.6 CDI85083.1 - 7.2 5.6 15.0 7.5 5.5 15.0 1.0 1 0 0 1 1 1 0 Protein family of FAM222A Spt20 PF12090.8 CDI85083.1 - 9 5.8 21.0 11 5.6 21.0 1.1 1 0 0 1 1 1 0 Spt20 family Afi1 PF07792.12 CDI85084.1 - 0.022 15.2 21.2 0.026 15.0 21.2 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PBP1_TM PF14812.6 CDI85084.1 - 0.13 12.6 9.0 0.2 12.1 9.0 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Gti1_Pac2 PF09729.9 CDI85084.1 - 0.16 12.0 21.5 0.2 11.8 21.5 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family Connexin PF00029.19 CDI85084.1 - 0.17 11.6 19.8 0.21 11.3 19.8 1.1 1 0 0 1 1 1 0 Connexin PIP5K PF01504.18 CDI85084.1 - 0.26 10.5 19.0 0.33 10.1 19.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Kei1 PF08552.11 CDI85084.1 - 0.39 10.6 16.7 0.43 10.4 16.7 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 MMM1 PF10296.9 CDI85084.1 - 0.57 9.2 15.6 0.7 8.9 15.6 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 DUF2370 PF10176.9 CDI85084.1 - 1.2 8.8 15.5 1.3 8.6 15.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) V_ATPase_I PF01496.19 CDI85084.1 - 1.5 6.6 30.8 1.8 6.4 30.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S64 PF08192.11 CDI85084.1 - 1.7 7.1 22.4 1.9 6.9 22.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF2828 PF11443.8 CDI85084.1 - 1.9 6.5 24.5 2.1 6.3 24.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) HCO3_cotransp PF00955.21 CDI85084.1 - 2 7.1 14.7 2.2 7.0 14.7 1.0 1 0 0 1 1 1 0 HCO3- transporter family CLN3 PF02487.17 CDI85084.1 - 2.1 7.3 21.6 2.3 7.2 21.6 1.0 1 0 0 1 1 1 0 CLN3 protein FAM60A PF15396.6 CDI85084.1 - 2.2 8.2 22.6 2.6 8.0 22.6 1.0 1 0 0 1 1 1 0 Protein Family FAM60A NPR3 PF03666.13 CDI85084.1 - 2.3 6.9 25.8 2.6 6.7 25.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 NARP1 PF12569.8 CDI85084.1 - 2.5 6.9 24.1 2.6 6.8 24.1 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DAG_kinase_N PF14513.6 CDI85084.1 - 2.6 8.2 25.7 3.1 8.0 25.7 1.0 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus SpoIIP PF07454.11 CDI85084.1 - 2.6 7.4 27.1 4.1 6.8 27.1 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.8 CDI85084.1 - 2.7 6.7 23.8 3.2 6.5 23.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 CDI85084.1 - 2.8 7.7 29.5 3.3 7.5 29.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 CDI85084.1 - 3.1 6.7 17.4 3.6 6.5 17.4 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) eIF-3_zeta PF05091.12 CDI85084.1 - 3.2 6.6 34.8 3.5 6.5 34.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SID-1_RNA_chan PF13965.6 CDI85084.1 - 3.5 5.9 15.2 3.4 6.0 15.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CRA PF06589.11 CDI85084.1 - 4 7.6 7.1 6 7.0 7.1 1.4 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) BORG_CEP PF14957.6 CDI85084.1 - 4 8.6 19.6 4.6 8.4 19.6 1.1 1 0 0 1 1 1 0 Cdc42 effector DDRGK PF09756.9 CDI85084.1 - 4 7.0 35.3 4.6 6.8 35.3 1.0 1 0 0 1 1 1 0 DDRGK domain Presenilin PF01080.17 CDI85084.1 - 4.1 6.1 34.5 4.8 5.8 34.5 1.0 1 0 0 1 1 1 0 Presenilin CobT PF06213.12 CDI85084.1 - 4.5 6.6 38.4 5.6 6.3 38.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PNISR PF15996.5 CDI85084.1 - 5.2 7.3 31.2 6.1 7.1 31.2 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Rtf2 PF04641.12 CDI85084.1 - 5.5 6.3 23.2 6 6.1 23.2 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger CSG2 PF16965.5 CDI85084.1 - 6.1 5.7 16.4 6.6 5.6 16.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Ureide_permease PF07168.11 CDI85084.1 - 6.3 5.4 11.7 8 5.1 11.7 1.2 1 0 0 1 1 1 0 Ureide permease Paramyxo_ncap PF00973.19 CDI85084.1 - 6.4 5.6 21.2 6.8 5.5 21.2 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Velvet PF11754.8 CDI85084.1 - 7.2 6.5 27.0 8.6 6.2 27.0 1.1 1 0 0 1 1 1 0 Velvet factor Zip PF02535.22 CDI85084.1 - 7.3 5.7 21.7 8.8 5.4 21.7 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Serinc PF03348.15 CDI85084.1 - 7.4 5.4 15.9 7.7 5.3 15.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) SLC12 PF03522.15 CDI85084.1 - 7.7 5.4 28.7 8.7 5.2 28.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI85084.1 - 7.9 6.5 23.7 9.3 6.2 23.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4050 PF13259.6 CDI85084.1 - 7.9 6.8 26.0 8.5 6.7 26.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Sec62 PF03839.16 CDI85084.1 - 8.1 5.9 22.7 8.8 5.8 22.7 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2464 PF10240.9 CDI85084.1 - 8.9 5.8 18.2 9.8 5.7 18.2 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 Afi1 PF07792.12 CDI85085.1 - 6.9e-05 23.3 6.5 8.5e-05 23.0 6.5 1.2 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Neur_chan_memb PF02932.16 CDI85085.1 - 0.0019 18.3 6.2 0.0019 18.3 6.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region IFT57 PF10498.9 CDI85085.1 - 0.0022 17.0 18.3 0.0028 16.7 18.3 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 LMBR1 PF04791.16 CDI85085.1 - 0.0056 15.6 0.4 0.0056 15.6 0.4 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein TFIIA PF03153.13 CDI85085.1 - 0.021 14.8 34.7 0.028 14.4 34.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SID-1_RNA_chan PF13965.6 CDI85085.1 - 0.03 12.7 3.2 0.031 12.7 3.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CCSAP PF15748.5 CDI85085.1 - 0.033 14.4 16.6 0.042 14.0 16.6 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated RR_TM4-6 PF06459.12 CDI85085.1 - 0.039 13.8 18.3 0.048 13.5 18.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 CDI85085.1 - 0.052 13.7 12.1 0.065 13.4 12.1 1.2 1 0 0 1 1 1 0 DDHD domain NARP1 PF12569.8 CDI85085.1 - 0.097 11.6 22.3 0.081 11.8 20.9 1.4 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Tim54 PF11711.8 CDI85085.1 - 0.1 11.4 15.8 0.13 11.0 15.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF913 PF06025.12 CDI85085.1 - 0.19 10.7 11.5 0.25 10.3 11.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) EOS1 PF12326.8 CDI85085.1 - 0.21 11.5 4.9 0.28 11.1 4.9 1.3 1 0 0 1 1 1 0 N-glycosylation protein Endostatin PF06482.11 CDI85085.1 - 0.21 11.0 12.9 0.27 10.7 12.9 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CPSF100_C PF13299.6 CDI85085.1 - 0.24 11.5 15.2 0.43 10.8 15.2 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Asp-B-Hydro_N PF05279.11 CDI85085.1 - 0.29 11.2 18.6 0.3 11.1 18.6 1.2 1 1 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4192 PF13830.6 CDI85085.1 - 0.3 11.1 3.6 0.4 10.7 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) SpoIIP PF07454.11 CDI85085.1 - 0.31 10.5 20.7 0.4 10.1 20.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) NPR3 PF03666.13 CDI85085.1 - 0.36 9.6 16.7 0.46 9.2 16.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3807 PF12720.7 CDI85085.1 - 0.36 11.1 24.3 0.54 10.5 24.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) GPCR_chapero_1 PF11904.8 CDI85085.1 - 0.39 10.1 10.7 0.48 9.8 10.7 1.1 1 0 0 1 1 1 0 GPCR-chaperone Band_3_cyto PF07565.13 CDI85085.1 - 0.41 10.4 18.6 0.55 10.0 18.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2052 PF09747.9 CDI85085.1 - 0.44 10.6 20.6 0.61 10.2 20.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SprA-related PF12118.8 CDI85085.1 - 0.46 9.6 33.5 0.63 9.1 33.5 1.2 1 0 0 1 1 1 0 SprA-related family MDMPI_N PF11716.8 CDI85085.1 - 0.51 11.0 4.1 0.25 12.0 1.8 1.7 2 0 0 2 2 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain PAT1 PF09770.9 CDI85085.1 - 0.69 8.1 26.3 0.85 7.8 26.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BORG_CEP PF14957.6 CDI85085.1 - 0.7 11.1 11.2 1.3 10.2 11.2 1.5 1 0 0 1 1 1 0 Cdc42 effector DUF853 PF05872.12 CDI85085.1 - 0.71 8.4 10.9 0.87 8.1 10.9 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF5308 PF17233.2 CDI85085.1 - 0.85 9.8 16.0 0.17 12.1 12.8 1.5 2 0 0 2 2 1 0 Family of unknown function (DUF5308) DUF2126 PF09899.9 CDI85085.1 - 1.3 7.1 13.8 1.6 6.7 13.8 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF2072 PF09845.9 CDI85085.1 - 1.3 9.3 14.9 2.1 8.6 14.9 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein DUF2828 PF11443.8 CDI85085.1 - 1.4 6.9 20.2 1.9 6.5 20.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4746 PF15928.5 CDI85085.1 - 1.4 8.3 19.8 1.9 7.8 19.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Hid1 PF12722.7 CDI85085.1 - 1.6 6.7 17.7 1.9 6.5 17.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CSG2 PF16965.5 CDI85085.1 - 1.7 7.5 12.5 2.2 7.1 12.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator MMU163 PF17119.5 CDI85085.1 - 1.7 7.8 9.3 2.4 7.2 9.3 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis TMEM214 PF10151.9 CDI85085.1 - 1.7 7.0 16.0 2.5 6.5 16.0 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator CDC45 PF02724.14 CDI85085.1 - 1.7 6.8 18.4 2.1 6.5 18.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 CDI85085.1 - 1.8 8.3 15.7 2.3 7.9 15.7 1.1 1 0 0 1 1 1 0 Connexin FAM60A PF15396.6 CDI85085.1 - 1.8 8.5 15.1 2.4 8.1 15.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 CDI85085.1 - 2.1 7.0 24.6 2.8 6.6 24.6 1.1 1 0 0 1 1 1 0 Presenilin SUFU_C PF12470.8 CDI85085.1 - 2.1 8.3 12.8 3.2 7.7 12.8 1.2 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain HemX PF04375.14 CDI85085.1 - 2.2 7.5 38.7 2.9 7.1 38.7 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Borrelia_P83 PF05262.11 CDI85085.1 - 2.2 6.7 20.9 2.5 6.5 20.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein RPN2_C PF18004.1 CDI85085.1 - 2.9 7.8 23.0 4.7 7.1 23.0 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pex14_N PF04695.13 CDI85085.1 - 3.1 8.4 30.0 0.18 12.5 22.0 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Gti1_Pac2 PF09729.9 CDI85085.1 - 3.3 7.8 17.7 4.6 7.3 17.7 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family V_ATPase_I PF01496.19 CDI85085.1 - 3.3 5.5 21.8 4.2 5.2 21.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 CDI85085.1 - 3.4 6.9 20.4 5.2 6.3 20.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3292 PF11696.8 CDI85085.1 - 3.4 5.9 14.6 4.4 5.6 14.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) GvpL_GvpF PF06386.11 CDI85085.1 - 3.5 7.5 17.3 5.1 6.9 17.3 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Cellulose_synt PF03552.14 CDI85085.1 - 4.1 5.8 7.6 4.7 5.6 7.6 1.0 1 0 0 1 1 1 0 Cellulose synthase eIF-3_zeta PF05091.12 CDI85085.1 - 4.1 6.3 25.6 5.4 5.9 25.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rtf2 PF04641.12 CDI85085.1 - 4.5 6.6 19.0 6 6.2 19.0 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger ALMT PF11744.8 CDI85085.1 - 4.6 6.0 16.4 5.8 5.6 16.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PA26 PF04636.13 CDI85085.1 - 5.6 5.8 14.4 7 5.4 14.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PPL5 PF18168.1 CDI85085.1 - 5.7 6.1 16.6 7.4 5.8 16.6 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF1764 PF08576.10 CDI85085.1 - 5.7 7.9 17.9 11 6.9 17.9 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) SLC12 PF03522.15 CDI85085.1 - 5.8 5.8 20.2 7.6 5.4 20.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CLN3 PF02487.17 CDI85085.1 - 6 5.8 17.6 7.9 5.4 17.6 1.1 1 0 0 1 1 1 0 CLN3 protein Pal1 PF08316.11 CDI85085.1 - 6.1 7.6 12.0 9.5 7.0 12.0 1.3 1 0 0 1 1 1 0 Pal1 cell morphology protein EPL1 PF10513.9 CDI85085.1 - 6.5 7.1 22.7 11 6.3 22.7 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like MDM31_MDM32 PF08118.11 CDI85085.1 - 6.7 5.3 12.2 8.4 4.9 12.2 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF1980 PF09323.10 CDI85085.1 - 7.3 6.5 13.1 11 5.9 13.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) GREB1 PF15782.5 CDI85085.1 - 7.8 3.5 17.0 9.2 3.2 17.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FAM176 PF14851.6 CDI85085.1 - 8.1 6.1 15.4 12 5.5 15.4 1.2 1 0 0 1 1 1 0 FAM176 family GNAT_acetyltr_2 PF13718.6 CDI85085.1 - 8.2 5.7 13.6 15 4.9 13.6 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase 2 eIF3_subunit PF08597.10 CDI85085.1 - 8.6 6.2 24.6 13 5.6 24.6 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Lin-8 PF03353.15 CDI85085.1 - 9.6 5.7 25.3 13 5.3 25.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Collagen PF01391.18 CDI85086.1 - 0.0023 17.6 25.5 0.0023 17.6 25.5 3.7 2 1 1 3 3 3 1 Collagen triple helix repeat (20 copies) Spt20 PF12090.8 CDI85086.1 - 0.056 13.1 29.8 0.57 9.8 11.8 2.1 2 0 0 2 2 2 0 Spt20 family DUF3801 PF12687.7 CDI85086.1 - 0.28 11.3 7.1 0.41 10.7 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) SR-25 PF10500.9 CDI85086.1 - 1.2 8.7 18.0 2.7 7.5 18.0 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.19 CDI85086.1 - 3.2 8.4 11.7 3.2 8.4 8.9 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein SprA-related PF12118.8 CDI85086.1 - 3.4 6.7 23.0 3.4 6.7 4.6 2.2 2 0 0 2 2 2 0 SprA-related family Ndc1_Nup PF09531.10 CDI85086.1 - 3.5 6.2 11.8 4.6 5.8 11.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SPX PF03105.19 CDI85086.1 - 4.9 7.0 13.9 6.9 6.5 13.9 1.1 1 0 0 1 1 1 0 SPX domain SR-25 PF10500.9 CDI85087.1 - 0.0076 15.9 20.2 0.009 15.6 20.2 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CCDC106 PF15794.5 CDI85087.1 - 0.19 11.4 24.4 0.21 11.3 24.4 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF1635 PF07795.11 CDI85087.1 - 0.3 10.9 24.9 0.38 10.6 24.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) CDK2AP PF09806.9 CDI85087.1 - 5.5 7.0 24.5 6.4 6.8 24.5 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein ASD2 PF08687.11 CDI85087.1 - 8.7 5.8 24.9 8.9 5.8 24.9 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 RskA PF10099.9 CDI85088.1 - 1.8e-05 25.1 1.6 1.8e-05 25.1 1.6 2.3 2 0 0 2 2 2 1 Anti-sigma-K factor rskA Pex14_N PF04695.13 CDI85088.1 - 3.9e-05 24.4 36.8 0.00028 21.6 10.1 2.2 2 0 0 2 2 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region SURF6 PF04935.12 CDI85088.1 - 0.00083 19.2 21.3 0.0064 16.3 9.8 2.1 2 0 0 2 2 2 2 Surfeit locus protein 6 TFIIA PF03153.13 CDI85088.1 - 0.006 16.6 56.4 0.097 12.7 18.9 2.0 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit ABC2_membrane_2 PF12679.7 CDI85088.1 - 0.0071 15.7 0.7 2.4 7.4 0.0 2.1 2 0 0 2 2 2 1 ABC-2 family transporter protein TMEM51 PF15345.6 CDI85088.1 - 0.0072 16.2 21.5 0.21 11.4 10.5 2.1 2 0 0 2 2 2 2 Transmembrane protein 51 EPL1 PF10513.9 CDI85088.1 - 0.021 15.2 6.4 0.021 15.2 6.4 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like TRAP_alpha PF03896.16 CDI85088.1 - 0.034 13.4 8.0 0.67 9.1 4.1 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit N6_N4_Mtase PF01555.18 CDI85088.1 - 0.051 13.3 0.0 0.4 10.3 0.0 2.0 1 1 0 1 1 1 0 DNA methylase DcuA_DcuB PF03605.14 CDI85088.1 - 0.054 12.4 6.7 1.3 7.8 0.1 2.0 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter PRC2_HTH_1 PF18118.1 CDI85088.1 - 0.09 13.6 15.8 0.84 10.5 1.7 2.2 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Trp_oprn_chp PF09534.10 CDI85088.1 - 0.1 12.4 5.4 0.13 12.1 0.3 2.2 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DDHD PF02862.17 CDI85088.1 - 0.12 12.6 18.7 0.65 10.1 8.1 2.1 2 0 0 2 2 2 0 DDHD domain Suf PF05843.14 CDI85088.1 - 0.13 12.3 31.2 0.44 10.5 9.0 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) SpoIIP PF07454.11 CDI85088.1 - 0.19 11.2 24.0 0.43 10.0 10.9 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) CPSF100_C PF13299.6 CDI85088.1 - 0.26 11.5 19.6 0.4 10.8 0.9 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 CDI85088.1 - 0.28 10.9 18.8 0.98 9.1 0.2 2.1 2 0 0 2 2 2 0 Connexin MecA PF05389.12 CDI85088.1 - 0.4 10.3 18.0 0.77 9.3 2.1 2.1 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) FmiP_Thoc5 PF09766.9 CDI85088.1 - 0.43 9.8 26.7 0.37 10.0 2.6 2.0 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 CDC45 PF02724.14 CDI85088.1 - 0.54 8.5 16.2 1.7 6.8 9.3 2.0 2 0 0 2 2 2 0 CDC45-like protein FHIPEP PF00771.20 CDI85088.1 - 0.6 8.5 16.4 0.13 10.7 1.1 2.0 2 0 0 2 2 2 0 FHIPEP family BAF1_ABF1 PF04684.13 CDI85088.1 - 0.67 8.9 18.7 0.31 10.0 1.9 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Peroxin-13_N PF04088.13 CDI85088.1 - 0.83 9.9 16.0 3.1 8.1 1.3 2.1 2 0 0 2 2 2 0 Peroxin 13, N-terminal region MMR1 PF08505.10 CDI85088.1 - 0.94 9.7 30.2 2.4 8.4 15.2 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein GOLD_2 PF13897.6 CDI85088.1 - 1 9.9 6.5 2.9 8.4 2.8 2.1 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking FAM76 PF16046.5 CDI85088.1 - 1.2 8.4 24.5 1.6 8.0 13.3 2.0 2 0 0 2 2 2 0 FAM76 protein DUF702 PF05142.12 CDI85088.1 - 1.3 9.5 26.4 1.3 9.5 12.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Jak1_Phl PF17887.1 CDI85088.1 - 1.4 8.9 23.5 0.37 10.8 1.5 2.1 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain FAM176 PF14851.6 CDI85088.1 - 1.5 8.5 16.3 8.9 6.0 0.2 2.1 2 0 0 2 2 2 0 FAM176 family TERB2 PF15101.6 CDI85088.1 - 1.6 8.8 36.0 3.2 7.8 20.7 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF5308 PF17233.2 CDI85088.1 - 1.6 8.9 21.5 1.1 9.5 6.6 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5308) DUF4820 PF16091.5 CDI85088.1 - 1.7 8.0 21.7 0.37 10.1 2.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF2722 PF10846.8 CDI85088.1 - 1.7 7.5 63.0 1 8.2 20.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF5427 PF10310.9 CDI85088.1 - 1.8 7.5 26.2 2 7.3 4.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5427) Neur_chan_memb PF02932.16 CDI85088.1 - 2 8.4 17.9 2 8.4 0.8 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region HNOBA PF07701.14 CDI85088.1 - 2.3 7.6 16.5 2.4 7.5 0.8 2.1 2 0 0 2 2 2 0 Heme NO binding associated DUF4770 PF15994.5 CDI85088.1 - 2.3 8.4 28.2 2.2 8.5 12.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Velvet PF11754.8 CDI85088.1 - 2.4 8.0 22.1 3.3 7.6 4.1 2.1 2 0 0 2 2 2 0 Velvet factor RED_N PF07808.13 CDI85088.1 - 2.4 7.7 29.6 0.2 11.2 12.5 2.0 2 0 0 2 2 2 0 RED-like protein N-terminal region DUF3504 PF12012.8 CDI85088.1 - 2.5 8.0 14.0 1.1 9.1 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3504) Eapp_C PF10238.9 CDI85088.1 - 2.9 7.9 27.6 5.1 7.2 5.7 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein BAT2_N PF07001.11 CDI85088.1 - 3 8.3 27.8 2.4 8.6 7.2 2.1 2 0 0 2 2 2 0 BAT2 N-terminus DUF719 PF05334.13 CDI85088.1 - 3.3 7.9 21.5 0.92 9.7 1.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF719) MAM33 PF02330.16 CDI85088.1 - 4 7.3 19.4 3 7.7 2.5 2.1 2 0 0 2 2 2 0 Mitochondrial glycoprotein Presenilin PF01080.17 CDI85088.1 - 4.6 5.9 30.4 1 8.1 5.4 2.1 2 0 0 2 2 2 0 Presenilin AIF_C PF14721.6 CDI85088.1 - 4.9 7.5 25.3 0.41 11.0 3.8 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term NinG PF05766.12 CDI85088.1 - 5 7.0 22.0 1.9 8.4 1.2 2.1 2 0 0 2 2 2 0 Bacteriophage Lambda NinG protein Gaa1 PF04114.14 CDI85088.1 - 5 6.0 7.7 6.1 5.7 0.3 2.0 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component ARF7EP_C PF14949.6 CDI85088.1 - 5 7.8 20.4 1.2 9.8 1.7 2.2 2 0 0 2 2 2 0 ARF7 effector protein C-terminus Tim54 PF11711.8 CDI85088.1 - 5.3 5.7 23.1 3.9 6.2 3.7 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF3807 PF12720.7 CDI85088.1 - 5.3 7.3 33.7 2.9 8.1 16.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) LPP20 PF02169.16 CDI85088.1 - 5.5 7.4 26.4 4.8 7.6 10.1 2.2 2 0 0 2 2 2 0 LPP20 lipoprotein Spt20 PF12090.8 CDI85088.1 - 5.7 6.5 76.8 0.87 9.1 24.1 2.1 2 0 0 2 2 2 0 Spt20 family CTU2 PF10288.9 CDI85088.1 - 6 7.1 24.2 3.8 7.8 4.8 2.2 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 PA26 PF04636.13 CDI85088.1 - 7 5.5 18.9 4.9 6.0 1.0 2.0 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) AUX_IAA PF02309.16 CDI85088.1 - 7 6.4 12.3 9.5 6.0 0.3 2.1 2 0 0 2 2 2 0 AUX/IAA family tRNA_lig_CPD PF08302.11 CDI85088.1 - 7.2 6.0 21.5 0.42 10.0 4.0 2.3 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain CCDC53 PF10152.9 CDI85088.1 - 7.3 7.0 28.3 1.9 8.9 5.1 2.1 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex RPA43_OB PF17875.1 CDI85088.1 - 7.3 7.2 17.9 8.5 7.0 1.2 2.1 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I SARAF PF06682.12 CDI85088.1 - 7.4 6.1 21.3 6 6.4 5.2 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Pet20 PF08692.10 CDI85088.1 - 7.7 7.2 10.3 25 5.6 4.5 2.2 2 0 0 2 2 2 0 Mitochondrial protein Pet20 NPR3 PF03666.13 CDI85088.1 - 7.8 5.2 20.4 2.5 6.8 9.9 2.0 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2052 PF09747.9 CDI85088.1 - 8 6.5 23.2 6.3 6.9 3.1 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF775 PF05603.12 CDI85088.1 - 8.1 5.9 27.5 1.6 8.2 5.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF775) Gti1_Pac2 PF09729.9 CDI85088.1 - 9.1 6.3 20.7 9.3 6.3 2.2 2.0 2 0 0 2 2 2 0 Gti1/Pac2 family DUF4050 PF13259.6 CDI85088.1 - 9.2 6.5 20.1 3.2 8.0 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) ArsP_2 PF11449.8 CDI85088.1 - 9.3 5.3 7.6 8 5.6 2.4 2.0 2 0 0 2 2 2 0 Putative, 10TM heavy-metal exporter PBP1_TM PF14812.6 CDI85088.1 - 9.4 6.7 10.3 7.2 7.1 5.2 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RR_TM4-6 PF06459.12 CDI85088.1 - 9.6 5.9 28.9 2.1 8.1 2.2 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 EOS1 PF12326.8 CDI85088.1 - 9.6 6.1 18.8 6.5 6.7 0.3 2.1 2 0 0 2 2 2 0 N-glycosylation protein Ribosomal_60s PF00428.19 CDI85089.1 - 0.23 12.0 16.6 1 10.0 7.0 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein RR_TM4-6 PF06459.12 CDI85089.1 - 0.32 10.8 26.2 0.039 13.8 7.0 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Shadoo PF14999.6 CDI85089.1 - 0.43 10.7 7.3 6 7.0 4.0 2.2 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Med15 PF09606.10 CDI85089.1 - 1.9 7.1 66.4 0.59 8.8 30.6 2.0 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal ALMT PF11744.8 CDI85089.1 - 3.6 6.3 23.4 0.16 10.8 5.9 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter Plasmodium_Vir PF05795.11 CDI85091.1 - 0.98 8.8 17.0 1.4 8.3 17.0 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein GET2 PF08690.10 CDI85091.1 - 6.7 6.3 31.9 7.3 6.2 31.9 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 CDC45 PF02724.14 CDI85091.1 - 7.8 4.7 28.8 9.2 4.4 28.8 1.2 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI85091.1 - 7.9 5.4 30.8 9.8 5.1 30.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SID-1_RNA_chan PF13965.6 CDI85093.1 - 1.1 7.5 2.8 1.5 7.1 2.8 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 LMBR1 PF04791.16 CDI85093.1 - 4.5 6.1 12.8 5.6 5.8 12.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Peptidase_U57 PF05582.12 CDI85093.1 - 6.1 6.0 10.6 12 5.0 10.6 1.5 1 0 0 1 1 1 0 YabG peptidase U57 Glyco_hydro_9 PF00759.19 CDI85093.1 - 8.4 5.7 26.4 14 4.9 26.4 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 9 Lin-8 PF03353.15 CDI85094.1 - 0.15 11.6 26.2 0.076 12.6 13.5 2.4 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist UCH PF00443.29 CDI85094.1 - 0.22 11.0 4.6 1.4 8.3 4.6 2.3 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Neur_chan_memb PF02932.16 CDI85094.1 - 0.87 9.6 20.5 0.33 11.0 9.5 2.5 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region SID-1_RNA_chan PF13965.6 CDI85094.1 - 0.9 7.9 5.9 1.5 7.1 5.9 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 CDI85094.1 - 1.7 7.6 23.1 0.26 10.3 13.4 2.3 2 0 0 2 2 2 0 Solute carrier family 12 ALMT PF11744.8 CDI85094.1 - 1.9 7.2 27.4 0.16 10.7 17.7 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter SOBP PF15279.6 CDI85094.1 - 4.7 7.7 23.4 1.6 9.3 14.2 2.3 2 0 0 2 2 2 0 Sine oculis-binding protein BORG_CEP PF14957.6 CDI85094.1 - 5.4 8.2 13.4 4.9 8.3 7.0 2.7 2 0 0 2 2 2 0 Cdc42 effector Draxin PF15550.6 CDI85094.1 - 6 6.6 13.0 0.91 9.3 5.5 2.4 2 0 0 2 2 2 0 Draxin Nha1_C PF08619.10 CDI85094.1 - 6.9 5.8 23.5 0.92 8.6 1.8 2.2 2 0 0 2 2 2 0 Alkali metal cation/H+ antiporter Nha1 C terminus O-antigen_lig PF13425.6 CDI85094.1 - 6.9 5.3 11.2 12 4.5 11.2 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF966 PF06136.13 CDI85094.1 - 9.3 5.9 15.8 0.59 9.8 5.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF966) Cyt-b5 PF00173.28 CDI85095.1 - 7e-06 26.1 0.0 1.8e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CCDC142 PF14923.6 CDI85095.1 - 0.017 13.9 0.9 0.027 13.2 0.9 1.2 1 0 0 1 1 1 0 Coiled-coil protein 142 Macoilin PF09726.9 CDI85095.1 - 1.3 7.4 5.5 3.4 6.1 5.5 1.7 1 0 0 1 1 1 0 Macoilin family DLIC PF05783.11 CDI85096.1 - 2.2 7.0 15.6 0.066 12.0 6.8 2.0 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) IMUP PF15761.5 CDI85096.1 - 2.9 8.6 25.9 1.3 9.7 14.9 2.6 2 0 0 2 2 2 0 Immortalisation up-regulated protein Baculo_PP31 PF05311.11 CDI85097.1 - 0.85 9.1 5.7 0.88 9.0 5.7 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) RskA PF10099.9 CDI85097.1 - 2.2 8.5 20.7 2.9 8.2 20.7 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA R_equi_Vir PF05526.11 CDI85097.1 - 4.3 7.2 9.6 5 7.0 9.6 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein UCH PF00443.29 CDI85098.1 - 4.6e-21 75.5 0.0 4.6e-21 75.5 0.0 2.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Spt20 PF12090.8 CDI85098.1 - 0.0039 16.8 7.2 0.0039 16.8 7.2 4.2 3 1 1 4 4 4 2 Spt20 family EFhand_Ca_insen PF08726.10 CDI85098.1 - 0.08 13.0 2.6 0.38 10.9 2.6 2.2 1 0 0 1 1 1 0 Ca2+ insensitive EF hand Dala_Dala_lig_N PF01820.21 CDI85098.1 - 1.5 9.4 7.3 7.3 7.1 4.0 3.6 2 1 0 2 2 2 0 D-ala D-ala ligase N-terminus RICTOR_N PF14664.6 CDI85099.1 - 0.089 11.8 0.2 0.11 11.5 0.2 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term DUF3159 PF11361.8 CDI85100.1 - 0.00013 21.8 0.3 0.00016 21.5 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3159) Phage_holin_2_3 PF16080.5 CDI85100.1 - 0.1 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage holin family HP1 OATP PF03137.20 CDI85100.1 - 0.27 9.5 0.2 0.41 8.9 0.1 1.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family RskA PF10099.9 CDI85101.1 - 3.7e-05 24.1 28.2 3.7e-05 24.1 28.2 4.5 1 1 2 3 3 1 1 Anti-sigma-K factor rskA EPL1 PF10513.9 CDI85101.1 - 0.0013 19.2 3.4 0.0022 18.4 3.4 1.5 1 0 0 1 1 1 1 Enhancer of polycomb-like Gti1_Pac2 PF09729.9 CDI85101.1 - 0.0027 17.8 0.3 0.0027 17.8 0.3 1.4 1 0 0 1 1 1 1 Gti1/Pac2 family Lin-8 PF03353.15 CDI85101.1 - 0.0053 16.4 7.4 0.0059 16.2 7.4 1.2 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist Folate_carrier PF01770.18 CDI85101.1 - 0.01 14.6 7.9 0.022 13.5 7.9 1.5 1 0 0 1 1 1 0 Reduced folate carrier MecA PF05389.12 CDI85101.1 - 0.018 14.7 8.0 0.026 14.2 8.0 1.3 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) V_ATPase_I PF01496.19 CDI85101.1 - 0.051 11.5 10.1 0.061 11.2 10.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family OATP PF03137.20 CDI85101.1 - 0.058 11.7 4.5 0.084 11.1 4.5 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CLN3 PF02487.17 CDI85101.1 - 0.067 12.2 5.3 0.11 11.5 5.3 1.4 1 0 0 1 1 1 0 CLN3 protein eIF-3_zeta PF05091.12 CDI85101.1 - 0.069 12.1 13.8 0.084 11.8 13.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM176 PF14851.6 CDI85101.1 - 0.076 12.7 2.9 0.12 12.0 2.9 1.3 1 0 0 1 1 1 0 FAM176 family Connexin PF00029.19 CDI85101.1 - 0.076 12.8 4.2 0.1 12.4 4.2 1.2 1 0 0 1 1 1 0 Connexin SpoIIP PF07454.11 CDI85101.1 - 0.079 12.4 9.6 0.11 11.9 9.6 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.8 CDI85101.1 - 0.11 11.3 5.6 0.14 10.9 5.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SID-1_RNA_chan PF13965.6 CDI85101.1 - 0.12 10.8 4.1 0.15 10.4 4.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 O-antigen_lig PF13425.6 CDI85101.1 - 0.15 10.8 2.8 0.19 10.4 2.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Band_3_cyto PF07565.13 CDI85101.1 - 0.15 11.8 7.9 0.2 11.4 7.9 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF3807 PF12720.7 CDI85101.1 - 0.19 12.0 17.5 0.33 11.2 17.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) UPF0524 PF15823.5 CDI85101.1 - 0.23 10.9 5.8 0.43 9.9 5.8 1.5 1 0 0 1 1 1 0 UPF0524 of C3orf70 XAP5 PF04921.14 CDI85101.1 - 0.28 11.0 7.3 0.47 10.2 7.3 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator DUF4834 PF16118.5 CDI85101.1 - 0.33 12.0 14.1 0.6 11.1 14.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Plasmodium_Vir PF05795.11 CDI85101.1 - 0.34 10.3 1.6 0.39 10.1 1.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Rxt3 PF08642.10 CDI85101.1 - 0.4 11.5 3.0 0.67 10.7 3.0 1.5 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Sec62 PF03839.16 CDI85101.1 - 0.48 9.9 5.1 0.66 9.4 5.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 AAA_23 PF13476.6 CDI85101.1 - 0.51 10.8 11.7 0.64 10.5 11.7 1.1 1 0 0 1 1 1 0 AAA domain MDM31_MDM32 PF08118.11 CDI85101.1 - 0.63 8.6 6.5 0.93 8.1 6.5 1.2 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins TFB6 PF17110.5 CDI85101.1 - 0.67 9.7 5.3 1.1 9.0 5.3 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Rrn6 PF10214.9 CDI85101.1 - 0.99 7.8 17.8 1.2 7.5 17.8 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CSG2 PF16965.5 CDI85101.1 - 1.1 8.1 6.2 1.4 7.8 6.2 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator NEMP PF10225.9 CDI85101.1 - 1.1 8.9 5.8 1.7 8.3 5.8 1.2 1 0 0 1 1 1 0 NEMP family SLC12 PF03522.15 CDI85101.1 - 1.3 7.9 11.7 1.6 7.6 11.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4820 PF16091.5 CDI85101.1 - 1.4 8.3 11.9 2.2 7.6 11.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) EOS1 PF12326.8 CDI85101.1 - 1.4 8.8 5.7 2.1 8.2 5.7 1.3 1 0 0 1 1 1 0 N-glycosylation protein SOBP PF15279.6 CDI85101.1 - 1.5 9.4 19.2 2 9.0 19.2 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Utp14 PF04615.13 CDI85101.1 - 1.6 7.2 16.3 2 6.9 16.3 1.2 1 1 0 1 1 1 0 Utp14 protein ALMT PF11744.8 CDI85101.1 - 1.7 7.4 9.3 2.1 7.1 9.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter EIF4E-T PF10477.9 CDI85101.1 - 1.7 7.4 20.5 2 7.1 20.5 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF5523 PF17661.1 CDI85101.1 - 1.7 8.2 14.8 2.3 7.8 14.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) UPF0560 PF10577.9 CDI85101.1 - 2.5 6.5 18.4 3.6 6.0 18.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 CD20 PF04103.15 CDI85101.1 - 2.6 8.1 7.3 0.17 12.0 0.8 2.3 2 0 0 2 2 2 0 CD20-like family Suf PF05843.14 CDI85101.1 - 2.6 7.9 21.0 4 7.4 21.0 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PIP5K PF01504.18 CDI85101.1 - 2.7 7.1 9.9 3.9 6.6 9.9 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Presenilin PF01080.17 CDI85101.1 - 3.1 6.5 18.5 4.2 6.0 18.5 1.2 1 0 0 1 1 1 0 Presenilin EMC3_TMCO1 PF01956.16 CDI85101.1 - 3.8 7.2 11.7 5.9 6.6 11.7 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Serinc PF03348.15 CDI85101.1 - 4 6.2 9.9 6.3 5.6 9.9 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF1980 PF09323.10 CDI85101.1 - 4.1 7.3 8.9 6.8 6.6 8.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Neur_chan_memb PF02932.16 CDI85101.1 - 4.2 7.4 12.3 6.1 6.8 12.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region UPF0239 PF06783.11 CDI85101.1 - 4.7 7.5 8.4 15 5.9 8.4 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) RR_TM4-6 PF06459.12 CDI85101.1 - 5.3 6.8 13.3 8.6 6.1 13.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MMR1 PF08505.10 CDI85101.1 - 5.6 7.2 21.7 0.35 11.1 16.0 1.7 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein DUF2232 PF09991.9 CDI85101.1 - 7 5.7 15.6 0.24 10.6 7.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) Spore_coat_CotO PF14153.6 CDI85101.1 - 7.5 6.4 20.6 15 5.5 20.6 1.4 1 0 0 1 1 1 0 Spore coat protein CotO WBP-1 PF11669.8 CDI85101.1 - 8.5 7.1 9.8 15 6.3 9.4 1.6 1 1 0 1 1 1 0 WW domain-binding protein 1 PAT1 PF09770.9 CDI85101.1 - 9.8 4.3 29.8 12 4.0 29.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SR-25 PF10500.9 CDI85104.1 - 6.2e-05 22.7 11.5 6.2e-05 22.7 11.5 4.4 4 1 1 5 5 5 1 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI85104.1 - 0.0029 17.9 13.6 0.0029 17.9 13.6 7.3 1 1 5 6 6 6 2 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI85104.1 - 0.0079 15.2 1.3 0.0079 15.2 1.3 6.7 6 1 1 7 7 7 4 Protein of unknown function (DUF2722) DUF3405 PF11885.8 CDI85104.1 - 0.0084 14.8 1.8 0.0084 14.8 1.8 3.7 4 1 0 4 4 4 2 Protein of unknown function (DUF3405) Cwf_Cwc_15 PF04889.12 CDI85104.1 - 0.011 15.5 1.0 0.011 15.5 1.0 4.8 4 1 0 4 4 4 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 CDI85104.1 - 6.8 7.1 14.1 17 5.8 0.4 4.5 4 0 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CD20 PF04103.15 CDI85105.1 - 1.6 8.8 10.3 0.71 9.9 0.1 3.6 3 1 0 4 4 4 0 CD20-like family Activator_LAG-3 PF11498.8 CDI85106.1 - 2.4e-05 23.5 27.5 2.7e-05 23.3 27.5 1.3 1 0 0 1 1 1 1 Transcriptional activator LAG-3 TYW3 PF02676.14 CDI85106.1 - 0.0022 17.4 5.9 0.0027 17.1 5.9 1.2 1 0 0 1 1 1 1 Methyltransferase TYW3 LMBR1 PF04791.16 CDI85106.1 - 0.0041 16.1 8.5 0.0047 15.9 8.5 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Lin-8 PF03353.15 CDI85106.1 - 0.053 13.1 22.6 0.063 12.8 22.6 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist YL1 PF05764.13 CDI85106.1 - 0.15 12.2 27.6 0.2 11.8 27.6 1.3 1 0 0 1 1 1 0 YL1 nuclear protein TT_ORF1 PF02956.14 CDI85106.1 - 0.58 8.8 9.7 0.7 8.5 9.7 1.1 1 0 0 1 1 1 0 TT viral orf 1 DUF2151 PF10221.9 CDI85106.1 - 0.81 8.2 14.5 1 7.9 14.5 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator LptF_LptG PF03739.14 CDI85106.1 - 1.7 7.4 4.1 2.1 7.1 4.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG CDC45 PF02724.14 CDI85106.1 - 2.4 6.3 23.3 2.9 6.1 23.3 1.1 1 0 0 1 1 1 0 CDC45-like protein GREB1 PF15782.5 CDI85106.1 - 2.6 5.0 23.9 2.8 4.9 23.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 CDI85106.1 - 3.8 6.0 19.5 4.3 5.8 19.5 1.0 1 0 0 1 1 1 0 Macoilin family V_ATPase_I PF01496.19 CDI85106.1 - 3.9 5.3 15.0 4.1 5.2 15.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SOBP PF15279.6 CDI85106.1 - 4.6 7.8 13.7 6.5 7.3 13.7 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein EPL1 PF10513.9 CDI85107.1 - 0.0036 17.7 4.4 0.0036 17.7 4.4 3.5 3 0 0 3 3 3 2 Enhancer of polycomb-like Cwf_Cwc_15 PF04889.12 CDI85107.1 - 0.47 10.2 28.6 0.079 12.7 3.1 3.4 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein Fumble PF03630.14 CDI85107.1 - 2.4 7.3 6.8 1.3 8.1 2.8 2.1 2 0 0 2 2 2 0 Fumble RAP1 PF07218.11 CDI85107.1 - 2.6 6.2 14.5 5 5.3 14.5 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Peptidase_S49_N PF08496.10 CDI85108.1 - 9.8 6.2 22.3 0.21 11.6 5.5 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF5563 PF17718.1 CDI85109.1 - 9.3 5.8 8.3 11 5.5 8.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5563) Suf PF05843.14 CDI85110.1 - 0.12 12.3 22.2 0.15 12.0 22.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 CDI85110.1 - 0.15 12.0 35.9 0.21 11.5 35.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 CDI85110.1 - 0.24 11.2 15.6 0.28 11.0 15.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.6 CDI85110.1 - 0.3 11.1 11.5 0.37 10.8 11.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CDC27 PF09507.10 CDI85110.1 - 0.43 9.9 19.7 0.5 9.7 19.7 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF1682 PF07946.14 CDI85110.1 - 0.46 9.6 7.5 0.53 9.5 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) SAGA-Tad1 PF12767.7 CDI85110.1 - 0.52 10.0 13.8 0.61 9.8 13.8 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Endostatin PF06482.11 CDI85110.1 - 0.58 9.6 14.6 0.72 9.3 14.6 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Hamartin PF04388.12 CDI85110.1 - 0.6 8.7 16.0 0.7 8.5 16.0 1.0 1 0 0 1 1 1 0 Hamartin protein eIF-3_zeta PF05091.12 CDI85110.1 - 0.67 8.9 17.8 0.79 8.6 17.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Raftlin PF15250.6 CDI85110.1 - 1 8.1 14.2 1.1 7.9 14.2 1.0 1 0 0 1 1 1 0 Raftlin LAP1C PF05609.12 CDI85110.1 - 1.1 8.3 17.1 1.3 8.1 17.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF4407 PF14362.6 CDI85110.1 - 1.4 8.2 14.5 1.5 8.1 14.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hid1 PF12722.7 CDI85110.1 - 2.2 6.3 15.5 2.3 6.2 15.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 CDI85110.1 - 2.4 6.3 12.1 2.8 6.1 12.1 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF2828 PF11443.8 CDI85110.1 - 2.5 6.1 13.1 3 5.8 13.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PigN PF04987.14 CDI85110.1 - 2.6 6.8 4.1 2.9 6.6 4.1 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) DDHD PF02862.17 CDI85110.1 - 3.3 7.8 14.5 4.7 7.3 14.5 1.2 1 0 0 1 1 1 0 DDHD domain LMBR1 PF04791.16 CDI85110.1 - 3.4 6.5 5.5 3.2 6.5 5.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF5427 PF10310.9 CDI85110.1 - 3.6 6.4 23.5 4.8 6.0 23.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) RBP_receptor PF14752.6 CDI85110.1 - 4.4 5.8 6.5 5.5 5.4 6.5 1.1 1 0 0 1 1 1 0 Retinol binding protein receptor MAJIN PF15077.6 CDI85110.1 - 5.5 6.7 11.8 6.9 6.4 11.8 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Neur_chan_memb PF02932.16 CDI85110.1 - 5.8 6.9 12.2 7.5 6.5 12.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NPR3 PF03666.13 CDI85110.1 - 6.7 5.4 17.4 7.9 5.1 17.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Serinc PF03348.15 CDI85110.1 - 9 5.1 7.1 10 4.9 7.1 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) WTX PF09422.10 CDI85111.1 - 0.0027 16.8 10.2 0.0027 16.8 10.2 2.1 2 0 0 2 2 2 1 WTX protein GldM_C PF12080.8 CDI85111.1 - 0.014 15.6 0.3 0.014 15.6 0.3 3.4 2 1 1 4 4 4 0 GldM C-terminal domain XRN_M PF17846.1 CDI85111.1 - 7.1 5.5 31.5 2.1 7.2 16.4 2.3 2 0 0 2 2 2 0 Xrn1 helical domain rRNA_processing PF08524.11 CDI85112.1 - 0.012 15.6 9.0 0.016 15.3 9.0 1.1 1 0 0 1 1 1 0 rRNA processing Striatin PF08232.12 CDI85112.1 - 0.27 11.8 13.3 0.35 11.4 13.3 1.1 1 0 0 1 1 1 0 Striatin family Menin PF05053.13 CDI85112.1 - 0.49 8.7 11.0 0.56 8.5 11.0 1.0 1 0 0 1 1 1 0 Menin Synuclein PF01387.17 CDI85112.1 - 0.7 10.1 7.1 0.89 9.8 7.1 1.2 1 0 0 1 1 1 0 Synuclein Peptidase_M56 PF05569.11 CDI85112.1 - 0.92 8.6 4.3 1 8.5 4.3 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 Presenilin PF01080.17 CDI85112.1 - 1.4 7.6 16.2 1.6 7.4 16.2 1.0 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI85112.1 - 1.6 8.6 23.6 2.2 8.2 23.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SprA-related PF12118.8 CDI85112.1 - 2.1 7.4 28.5 2.8 7.0 28.5 1.2 1 0 0 1 1 1 0 SprA-related family Hydin_ADK PF17213.3 CDI85112.1 - 2.4 8.4 20.7 2.8 8.2 20.7 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DivIC PF04977.15 CDI85112.1 - 2.4 8.0 10.7 4.6 7.1 10.7 1.4 1 0 0 1 1 1 0 Septum formation initiator Hid1 PF12722.7 CDI85112.1 - 3.7 5.5 18.7 4.4 5.3 18.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM199X PF15814.5 CDI85112.1 - 4.9 6.1 24.5 5.9 5.8 24.5 1.0 1 0 0 1 1 1 0 Protein family FAM199X EphA2_TM PF14575.6 CDI85112.1 - 5.8 7.9 7.8 1.3e+02 3.6 7.8 2.1 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Tmemb_cc2 PF10267.9 CDI85112.1 - 6.3 5.8 22.2 7.4 5.6 22.2 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein EMG1 PF03587.14 CDI85113.1 - 0.013 15.1 2.2 0.022 14.4 0.0 2.4 3 1 0 3 3 3 0 EMG1/NEP1 methyltransferase Spt20 PF12090.8 CDI85113.1 - 0.019 14.6 53.7 0.091 12.4 5.0 3.6 4 0 0 4 4 4 0 Spt20 family Ctf8 PF09696.10 CDI85113.1 - 0.25 11.7 0.1 0.25 11.7 0.1 4.0 3 1 0 3 3 3 0 Ctf8 RskA PF10099.9 CDI85113.1 - 0.31 11.3 85.3 0.024 14.9 6.7 4.2 2 2 2 4 4 4 0 Anti-sigma-K factor rskA TPR_1 PF00515.28 CDI85114.1 - 1.2e-08 34.4 1.8 0.0013 18.4 0.2 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat PEX11 PF05648.14 CDI85114.1 - 0.0075 15.8 1.7 0.0075 15.8 1.7 3.6 2 1 0 2 2 2 1 Peroxisomal biogenesis factor 11 (PEX11) SID-1_RNA_chan PF13965.6 CDI85114.1 - 0.59 8.5 18.0 0.32 9.4 7.4 2.4 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Merozoite_SPAM PF07133.11 CDI85114.1 - 4 7.4 59.2 0.06 13.3 31.1 3.0 3 0 0 3 3 3 0 Merozoite surface protein (SPAM) Tyrosinase PF00264.20 CDI85114.1 - 7.9 6.7 21.9 6.3 7.0 2.1 2.5 2 0 0 2 2 2 0 Common central domain of tyrosinase CLN3 PF02487.17 CDI85115.1 - 0.011 14.8 0.1 0.015 14.4 0.1 1.2 1 0 0 1 1 1 0 CLN3 protein TAF1_subA PF14929.6 CDI85115.1 - 0.043 13.2 0.0 0.046 13.1 0.0 1.1 1 0 0 1 1 1 0 TAF RNA Polymerase I subunit A TMEM154 PF15102.6 CDI85115.1 - 0.19 11.6 14.6 0.06 13.2 10.1 2.4 2 1 0 2 2 2 0 TMEM154 protein family Ashwin PF15323.6 CDI85115.1 - 2.7 8.0 8.3 4 7.4 8.3 1.2 1 0 0 1 1 1 0 Developmental protein DUF4518 PF15008.6 CDI85116.1 - 0.00083 18.6 5.7 0.00083 18.6 5.7 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4518) zf-CHCC PF10276.9 CDI85116.1 - 0.02 15.0 0.0 0.046 13.8 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger domain Ofd1_CTDD PF10637.9 CDI85116.1 - 2.8 7.2 8.8 0.59 9.4 5.2 1.6 2 0 0 2 2 2 0 Oxoglutarate and iron-dependent oxygenase degradation C-term Spt20 PF12090.8 CDI85117.1 - 0.55 9.8 21.6 0.7 9.5 21.6 1.2 1 0 0 1 1 1 0 Spt20 family Neur_chan_memb PF02932.16 CDI85117.1 - 2.2 8.3 4.4 2.3 8.2 4.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TERB2 PF15101.6 CDI85117.1 - 2.3 8.2 10.3 3.3 7.7 10.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 GREB1 PF15782.5 CDI85117.1 - 3.1 4.8 11.3 2.9 4.9 11.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RR_TM4-6 PF06459.12 CDI85117.1 - 3.2 7.5 10.1 3.7 7.3 10.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SWI-SNF_Ssr4 PF08549.10 CDI85117.1 - 5.9 5.4 23.7 7.1 5.1 23.7 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) EPL1 PF10513.9 CDI85117.1 - 6.1 7.2 9.7 8.6 6.7 9.7 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF2722 PF10846.8 CDI85119.1 - 5.3e-05 22.3 23.9 0.00033 19.7 4.1 18.5 7 3 5 14 14 14 4 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI85119.1 - 0.0026 17.4 21.4 0.0026 17.4 21.4 18.5 8 7 4 12 12 12 1 Spt20 family Secretin_N_2 PF07655.13 CDI85119.1 - 0.0095 16.5 11.3 0.0095 16.5 11.3 20.3 11 4 3 15 15 15 1 Secretin N-terminal domain Spt20 PF12090.8 CDI85120.1 - 0.026 14.1 32.1 0.027 14.1 32.1 1.0 1 0 0 1 1 1 0 Spt20 family CNDH2_M PF16869.5 CDI85120.1 - 0.13 13.0 8.7 0.14 12.9 8.7 1.0 1 0 0 1 1 1 0 PF16858 CRF1 PF10380.9 CDI85120.1 - 0.16 12.3 4.3 0.17 12.2 4.3 1.1 1 0 0 1 1 1 0 Transcription factor CRF1 DUF2722 PF10846.8 CDI85120.1 - 0.21 10.5 25.9 0.19 10.6 25.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF3408 PF11888.8 CDI85120.1 - 0.25 11.5 12.2 0.25 11.4 12.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) CobT PF06213.12 CDI85120.1 - 0.68 9.3 15.4 0.69 9.2 15.4 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pex14_N PF04695.13 CDI85120.1 - 1.1 10.0 16.1 1.2 9.8 16.1 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region eIF-3_zeta PF05091.12 CDI85120.1 - 1.7 7.5 18.6 1.8 7.5 18.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Coilin_N PF15862.5 CDI85120.1 - 2 8.2 14.6 2.1 8.1 14.6 1.2 1 0 0 1 1 1 0 Coilin N-terminus PIEZO PF15917.5 CDI85120.1 - 2.4 7.6 21.9 2.6 7.5 21.9 1.0 1 0 0 1 1 1 0 Piezo DUF4834 PF16118.5 CDI85120.1 - 2.5 9.1 15.9 2.8 9.0 15.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TFIIA PF03153.13 CDI85120.1 - 3.4 7.6 33.0 3.6 7.5 33.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI85120.1 - 4.4 7.4 11.4 4.3 7.4 11.4 1.0 1 0 0 1 1 1 0 DDHD domain DUF1980 PF09323.10 CDI85120.1 - 4.8 7.1 8.7 4.8 7.1 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Presenilin PF01080.17 CDI85120.1 - 5 5.8 14.9 5 5.8 14.9 1.0 1 0 0 1 1 1 0 Presenilin EPL1 PF10513.9 CDI85120.1 - 5.8 7.3 14.9 6.4 7.1 14.9 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like TERB2 PF15101.6 CDI85120.1 - 5.8 6.9 19.0 6.2 6.8 19.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Suf PF05843.14 CDI85120.1 - 6 6.8 16.4 6.4 6.7 16.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Peptidase_S49_N PF08496.10 CDI85120.1 - 7 6.7 13.6 8 6.5 13.6 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Band_3_cyto PF07565.13 CDI85120.1 - 7.2 6.3 12.4 7.2 6.3 12.4 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Asparaginase_2 PF01112.18 CDI85120.1 - 8 5.4 8.4 8.3 5.3 8.4 1.0 1 0 0 1 1 1 0 Asparaginase FUN14 PF04930.15 CDI85120.1 - 8.1 6.9 6.0 9.6 6.7 6.0 1.1 1 0 0 1 1 1 0 FUN14 family DUF2828 PF11443.8 CDI85120.1 - 8.3 4.4 13.9 8.7 4.3 13.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) EIIBC-GUT_N PF03612.14 CDI85120.1 - 8.4 6.1 11.4 8.6 6.1 11.4 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus EOS1 PF12326.8 CDI85120.1 - 8.6 6.3 9.3 8.7 6.2 9.3 1.1 1 0 0 1 1 1 0 N-glycosylation protein MCU PF04678.13 CDI85120.1 - 8.7 6.4 11.4 8.7 6.4 11.4 1.0 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Connexin PF00029.19 CDI85120.1 - 9.7 5.9 11.4 9.8 5.9 11.4 1.0 1 0 0 1 1 1 0 Connexin LCIB_C_CA PF18599.1 CDI85121.1 - 2.2 7.5 20.9 2.6 7.3 20.9 1.2 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases RskA PF10099.9 CDI85122.1 - 1e-07 32.4 79.1 0.0039 17.5 10.1 7.4 3 2 2 5 5 5 4 Anti-sigma-K factor rskA PAP1 PF08601.10 CDI85122.1 - 6.2e-05 22.9 5.0 6.2e-05 22.9 5.0 4.2 3 3 1 4 4 4 1 Transcription factor PAP1 SR-25 PF10500.9 CDI85122.1 - 0.0014 18.3 8.1 0.0014 18.3 8.1 8.1 6 2 3 9 9 9 2 Nuclear RNA-splicing-associated protein Dynein_AAA_lid PF17852.1 CDI85122.1 - 0.029 14.5 0.4 0.029 14.5 0.4 2.5 2 0 0 2 2 2 0 Dynein heavy chain AAA lid domain RRM_1 PF00076.22 CDI85125.1 - 2e-17 62.8 0.1 3.5e-17 62.0 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SRP_SPB PF02978.19 CDI85125.1 - 0.021 15.5 2.2 0.024 15.3 0.8 1.7 2 0 0 2 2 2 0 Signal peptide binding domain TFIIA PF03153.13 CDI85125.1 - 4.6 7.1 10.9 5.4 6.9 10.8 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pol_alpha_B_N PF08418.10 CDI85129.1 - 0.015 15.3 12.0 0.017 15.1 12.0 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal OrsD PF12013.8 CDI85129.1 - 0.018 15.4 7.4 0.018 15.4 7.4 1.7 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D DUF572 PF04502.13 CDI85129.1 - 0.026 14.1 17.0 0.035 13.7 17.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) TFIIA PF03153.13 CDI85129.1 - 0.027 14.5 38.1 0.034 14.1 38.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4175 PF13779.6 CDI85129.1 - 0.029 12.3 32.4 0.034 12.1 32.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Presenilin PF01080.17 CDI85129.1 - 0.041 12.7 21.1 0.047 12.5 21.1 1.1 1 0 0 1 1 1 0 Presenilin DUF4050 PF13259.6 CDI85129.1 - 0.053 13.9 18.4 0.07 13.5 18.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) CDC27 PF09507.10 CDI85129.1 - 0.064 12.6 18.2 0.081 12.3 18.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 FAM60A PF15396.6 CDI85129.1 - 0.17 11.9 13.9 0.2 11.6 13.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Lin-8 PF03353.15 CDI85129.1 - 0.2 11.2 20.8 0.25 10.8 20.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Senescence_reg PF04520.13 CDI85129.1 - 0.22 12.3 12.3 0.32 11.8 12.3 1.3 1 0 0 1 1 1 0 Senescence regulator V_ATPase_I PF01496.19 CDI85129.1 - 0.31 8.9 17.2 0.36 8.7 17.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Hid1 PF12722.7 CDI85129.1 - 0.32 9.1 23.0 0.38 8.8 23.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM91_C PF14648.6 CDI85129.1 - 0.43 9.3 8.4 0.51 9.1 8.4 1.2 1 0 0 1 1 1 0 FAM91 C-terminus WTX PF09422.10 CDI85129.1 - 0.62 9.1 12.2 0.7 8.9 12.2 1.1 1 0 0 1 1 1 0 WTX protein ALMT PF11744.8 CDI85129.1 - 0.65 8.8 12.5 0.74 8.6 12.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter PAT1 PF09770.9 CDI85129.1 - 0.8 7.9 26.4 0.83 7.9 26.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ArsP_2 PF11449.8 CDI85129.1 - 0.84 8.8 4.0 0.2 10.8 0.7 1.6 2 0 0 2 2 2 0 Putative, 10TM heavy-metal exporter GET2 PF08690.10 CDI85129.1 - 0.92 9.1 16.0 1.1 8.9 16.0 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 MDM10 PF12519.8 CDI85129.1 - 0.94 8.3 11.7 1.1 8.0 11.7 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 GAGA_bind PF06217.12 CDI85129.1 - 1 9.6 14.7 1.2 9.4 14.7 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Neur_chan_memb PF02932.16 CDI85129.1 - 1.2 9.2 14.4 1.4 8.9 14.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Velvet PF11754.8 CDI85129.1 - 1.3 8.9 15.7 1.7 8.6 15.7 1.2 1 0 0 1 1 1 0 Velvet factor Het-C PF07217.11 CDI85129.1 - 1.4 7.3 14.0 1.8 7.0 14.0 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C GREB1 PF15782.5 CDI85129.1 - 1.5 5.8 18.3 1.6 5.7 18.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PA26 PF04636.13 CDI85129.1 - 1.7 7.5 14.7 1.9 7.3 14.7 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) TMEM214 PF10151.9 CDI85129.1 - 1.7 7.0 19.8 2.2 6.6 19.8 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator FTO_NTD PF12933.7 CDI85129.1 - 2.2 7.4 13.5 1.9 7.7 12.7 1.3 1 1 0 1 1 1 0 FTO catalytic domain NPR3 PF03666.13 CDI85129.1 - 2.3 6.9 17.2 2.8 6.6 17.2 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC12 PF03522.15 CDI85129.1 - 3 6.8 20.5 3.7 6.5 20.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Pex14_N PF04695.13 CDI85129.1 - 3.2 8.4 30.2 7 7.3 30.2 1.6 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Asp-B-Hydro_N PF05279.11 CDI85129.1 - 3.6 7.6 16.4 4.7 7.2 16.4 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Dsh_C PF12316.8 CDI85129.1 - 4 7.8 10.9 5.2 7.4 10.9 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Membralin PF09746.9 CDI85129.1 - 4.2 6.3 9.2 5.1 6.0 9.2 1.3 1 0 0 1 1 1 0 Tumour-associated protein AAA_11 PF13086.6 CDI85129.1 - 5.2 6.8 21.1 6.9 6.4 21.1 1.2 1 0 0 1 1 1 0 AAA domain DUF4569 PF15133.6 CDI85129.1 - 5.2 6.7 22.7 7 6.3 22.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Suf PF05843.14 CDI85129.1 - 5.4 6.9 24.6 8.6 6.2 24.6 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Zip PF02535.22 CDI85129.1 - 7.3 5.7 8.1 8.2 5.5 8.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter AUX_IAA PF02309.16 CDI85129.1 - 7.3 6.4 12.2 9.4 6.0 12.2 1.2 1 0 0 1 1 1 0 AUX/IAA family SUFU_C PF12470.8 CDI85129.1 - 7.4 6.6 16.2 0.55 10.3 11.2 1.7 1 1 1 2 2 2 0 Suppressor of Fused Gli/Ci N terminal binding domain RskA PF10099.9 CDI85130.1 - 1.7e-08 35.0 8.1 4.8e-05 23.7 0.0 5.8 1 1 4 5 5 5 2 Anti-sigma-K factor rskA FAM76 PF16046.5 CDI85130.1 - 0.0027 17.1 13.5 0.0027 17.1 13.5 3.2 2 1 1 3 3 3 1 FAM76 protein SCAI PF12070.8 CDI85130.1 - 2.2 7.0 36.3 0.076 11.9 6.8 2.2 2 0 0 2 2 2 0 Protein SCAI RskA PF10099.9 CDI85131.1 - 0.00029 21.2 0.2 0.00032 21.0 0.2 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF533 PF04391.12 CDI85131.1 - 0.00095 18.8 4.4 0.0012 18.4 4.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF533) FHIPEP PF00771.20 CDI85131.1 - 0.023 13.2 0.0 0.029 12.9 0.0 1.1 1 0 0 1 1 1 0 FHIPEP family Ribosomal_60s PF00428.19 CDI85131.1 - 0.043 14.4 0.2 0.06 13.9 0.2 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein TFIIA PF03153.13 CDI85131.1 - 0.047 13.7 8.8 0.054 13.5 8.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit HemX PF04375.14 CDI85131.1 - 0.059 12.6 10.8 0.078 12.3 10.8 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Roughex PF06020.11 CDI85131.1 - 0.065 12.3 0.6 0.071 12.2 0.6 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF2722 PF10846.8 CDI85131.1 - 0.078 11.9 8.6 0.096 11.6 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF4131 PF13567.6 CDI85131.1 - 0.08 12.6 0.6 1.4 8.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) EphA2_TM PF14575.6 CDI85131.1 - 0.17 12.8 0.3 4.2 8.3 0.2 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Suf PF05843.14 CDI85131.1 - 0.28 11.1 4.0 0.35 10.8 4.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Activator_LAG-3 PF11498.8 CDI85131.1 - 0.29 10.1 16.0 0.37 9.7 16.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI85131.1 - 1.6 8.3 17.3 1.1 8.8 15.5 1.5 2 0 0 2 2 2 0 Spt20 family GRP PF07172.11 CDI85131.1 - 6.2 7.6 5.3 7.7 7.3 0.1 2.2 2 0 0 2 2 2 0 Glycine rich protein family RskA PF10099.9 CDI85134.1 - 5e-06 26.9 6.9 7.5e-06 26.3 6.9 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA IF-2B PF01008.17 CDI85134.1 - 0.00029 20.1 0.5 0.00053 19.3 0.0 1.7 2 0 0 2 2 2 1 Initiation factor 2 subunit family DUF737 PF05300.11 CDI85134.1 - 0.00051 20.5 3.7 0.00051 20.5 3.7 1.4 2 0 0 2 2 1 1 Protein of unknown function (DUF737) Macoilin PF09726.9 CDI85134.1 - 0.004 15.8 17.5 0.0052 15.4 17.5 1.1 1 0 0 1 1 1 1 Macoilin family Methyltransf_34 PF11312.8 CDI85134.1 - 0.0079 15.5 0.1 0.014 14.7 0.1 1.3 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Sec62 PF03839.16 CDI85134.1 - 0.022 14.3 3.8 0.032 13.8 3.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Lin-8 PF03353.15 CDI85134.1 - 0.052 13.1 13.9 0.072 12.6 13.9 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CPSF100_C PF13299.6 CDI85134.1 - 0.067 13.4 2.0 0.13 12.5 2.0 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal PAT1 PF09770.9 CDI85134.1 - 0.081 11.2 22.6 0.097 10.9 22.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Glt_symporter PF03616.14 CDI85134.1 - 0.082 11.6 3.4 0.14 10.9 3.4 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter MMR1 PF08505.10 CDI85134.1 - 0.26 11.6 16.8 0.37 11.0 16.8 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein HemX PF04375.14 CDI85134.1 - 0.26 10.5 19.4 0.39 10.0 19.4 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase SLC12 PF03522.15 CDI85134.1 - 0.38 9.7 9.5 0.48 9.4 9.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CrgA PF06781.12 CDI85134.1 - 0.46 10.6 3.1 12 6.1 3.0 2.4 1 1 0 1 1 1 0 Cell division protein CrgA Ecl1 PF12855.7 CDI85134.1 - 0.47 11.6 18.6 0.84 10.8 18.6 1.5 1 1 0 1 1 1 0 ECL1/2/3 zinc binding proteins NST1 PF13945.6 CDI85134.1 - 1 9.5 20.8 1.9 8.5 20.8 1.5 1 1 0 1 1 1 0 Salt tolerance down-regulator IHABP4_N PF16174.5 CDI85134.1 - 1.4 9.5 12.8 2.8 8.5 12.8 1.4 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal DUF3446 PF11928.8 CDI85134.1 - 2.2 8.6 22.4 0.11 12.8 8.1 2.9 2 1 0 2 2 2 0 Early growth response N-terminal domain DcuC PF03606.15 CDI85134.1 - 4.7 5.5 7.8 1.5 7.2 0.1 2.1 1 1 1 2 2 2 0 C4-dicarboxylate anaerobic carrier RNA_pol_3_Rpc31 PF11705.8 CDI85134.1 - 6.2 7.0 8.0 8.7 6.5 8.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 SPX PF03105.19 CDI85134.1 - 9.7 6.0 19.5 16 5.3 19.6 1.3 1 1 0 1 1 1 0 SPX domain SID-1_RNA_chan PF13965.6 CDI85134.1 - 10 4.4 13.3 2.2 6.6 3.8 1.8 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 DUF615 PF04751.14 CDI85135.1 - 0.00024 21.1 1.5 0.00031 20.7 1.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF615) HetR_C PF18460.1 CDI85135.1 - 0.015 15.2 1.0 0.028 14.3 1.0 1.6 1 0 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain VPR PF00522.18 CDI85135.1 - 0.1 12.6 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 VPR/VPX protein ING PF12998.7 CDI85135.1 - 0.1 13.2 0.4 4.1 8.0 0.6 2.1 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding NleF_casp_inhib PF16809.5 CDI85135.1 - 0.11 12.4 0.4 0.2 11.5 0.4 1.5 1 1 0 1 1 1 0 NleF caspase inhibitor Fib_alpha PF08702.10 CDI85135.1 - 0.22 11.7 2.0 0.48 10.6 1.5 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF3486 PF11985.8 CDI85136.1 - 0.044 14.2 5.6 0.043 14.2 4.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3486) Bacillus_PapR PF05968.11 CDI85136.1 - 0.23 11.3 0.6 0.42 10.5 0.6 1.4 1 0 0 1 1 1 0 Bacillus PapR protein UCH PF00443.29 CDI85137.1 - 2.4e-17 63.3 0.0 2.8e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 CDI85137.1 - 6.1e-05 22.7 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UCH_1 PF13423.6 CDI85137.1 - 0.0025 17.5 0.0 0.0039 16.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase TBK1_ULD PF18396.1 CDI85137.1 - 0.0035 17.2 0.0 0.0085 16.0 0.0 1.5 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Fasciclin PF02469.22 CDI85138.1 - 0.0018 18.5 0.0 0.0043 17.3 0.0 1.5 1 0 0 1 1 1 1 Fasciclin domain SID-1_RNA_chan PF13965.6 CDI85139.1 - 0.22 9.9 1.8 5.2 5.4 0.1 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI85139.1 - 4.2 5.2 5.9 1.3 6.8 0.2 2.5 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family DUF966 PF06136.13 CDI85139.1 - 4.9 6.8 30.3 0.12 12.0 2.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF966) CSG2 PF16965.5 CDI85139.1 - 7.6 5.4 6.8 18 4.2 0.3 2.4 2 1 0 2 2 2 0 Ceramide synthase regulator Glyco_transf_7N PF13733.6 CDI85140.1 - 0.052 13.2 0.0 0.058 13.0 0.0 1.1 1 0 0 1 1 1 0 N-terminal region of glycosyl transferase group 7 GET2 PF08690.10 CDI85140.1 - 0.59 9.8 5.6 0.67 9.6 5.6 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 MSP1_C PF07462.11 CDI85140.1 - 2.5 6.7 6.0 2.7 6.6 6.0 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus BAF1_ABF1 PF04684.13 CDI85140.1 - 2.6 7.0 9.8 3.8 6.5 9.8 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FSA_C PF10479.9 CDI85140.1 - 6.1 4.8 10.7 6.7 4.7 10.7 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SR-25 PF10500.9 CDI85141.1 - 0.0013 18.4 10.6 0.0013 18.4 10.6 4.4 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein SPX PF03105.19 CDI85141.1 - 0.0046 16.9 34.4 0.0079 16.2 4.3 2.1 2 0 0 2 2 2 2 SPX domain Pex14_N PF04695.13 CDI85141.1 - 0.3 11.7 27.5 0.097 13.3 4.9 3.0 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region XAP5 PF04921.14 CDI85141.1 - 0.73 9.6 8.1 0.23 11.2 0.6 2.2 2 0 0 2 2 2 0 XAP5, circadian clock regulator EPL1 PF10513.9 CDI85141.1 - 1.1 9.7 13.3 6.7 7.1 0.7 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like Presenilin PF01080.17 CDI85141.1 - 1.5 7.5 19.8 0.8 8.4 9.6 2.2 2 0 0 2 2 2 0 Presenilin Gti1_Pac2 PF09729.9 CDI85141.1 - 2 8.5 21.1 5.7 7.0 1.8 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family DUF4936 PF16290.5 CDI85141.1 - 3.7 8.3 12.8 3.4 8.4 8.4 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4936) AAR2 PF05282.11 CDI85141.1 - 5.1 6.4 13.6 6.4 6.1 6.1 2.3 2 0 0 2 2 2 0 AAR2 protein Presenilin PF01080.17 CDI85142.1 - 1 8.0 85.5 0.23 10.2 32.6 2.0 2 0 0 2 2 2 0 Presenilin DUF3295 PF11702.8 CDI85142.1 - 3.3 6.9 60.9 0.055 12.8 21.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) DUF572 PF04502.13 CDI85142.1 - 4.8 6.7 71.1 7 6.2 71.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Spt20 PF12090.8 CDI85143.1 - 7.1e-05 22.5 16.7 7.1e-05 22.5 16.7 2.6 2 1 0 2 2 1 1 Spt20 family SUIM_assoc PF16619.5 CDI85143.1 - 0.00051 20.1 7.3 0.00051 20.1 7.3 5.5 3 2 0 3 3 2 1 Unstructured region C-term to UIM in Ataxin3 PTPRCAP PF15713.5 CDI85143.1 - 0.0035 17.6 1.3 0.0035 17.6 1.3 3.1 2 1 1 3 3 2 1 Protein tyrosine phosphatase receptor type C-associated SARAF PF06682.12 CDI85143.1 - 0.0047 16.6 12.0 0.28 10.8 5.7 2.1 2 0 0 2 2 2 2 SOCE-associated regulatory factor of calcium homoeostasis EPL1 PF10513.9 CDI85143.1 - 0.0087 16.5 27.5 0.18 12.2 3.4 3.1 3 0 0 3 3 3 2 Enhancer of polycomb-like SLC12 PF03522.15 CDI85143.1 - 0.02 14.0 23.4 0.24 10.4 13.4 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Presenilin PF01080.17 CDI85143.1 - 0.024 13.4 30.2 0.075 11.8 15.5 2.2 2 0 0 2 2 2 0 Presenilin Connexin PF00029.19 CDI85143.1 - 0.024 14.4 0.5 0.024 14.4 0.5 3.1 2 1 1 3 3 3 0 Connexin Eapp_C PF10238.9 CDI85143.1 - 0.08 13.0 27.0 1.6 8.8 3.8 3.2 3 0 0 3 3 3 0 E2F-associated phosphoprotein CCSAP PF15748.5 CDI85143.1 - 0.091 12.9 28.0 0.88 9.7 5.5 2.3 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DUF4050 PF13259.6 CDI85143.1 - 0.099 13.0 24.1 0.086 13.2 10.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) FAM60A PF15396.6 CDI85143.1 - 0.18 11.8 18.4 1.7 8.6 10.7 2.2 2 0 0 2 2 2 0 Protein Family FAM60A DUF2681 PF10883.8 CDI85143.1 - 0.19 12.2 50.8 0.62 10.5 14.5 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) Lin-8 PF03353.15 CDI85143.1 - 0.23 11.0 27.8 1.1 8.7 14.6 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist PAT1 PF09770.9 CDI85143.1 - 0.3 9.3 41.5 0.33 9.2 13.1 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF2722 PF10846.8 CDI85143.1 - 0.31 9.9 63.7 0.82 8.5 11.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) ALMT PF11744.8 CDI85143.1 - 0.66 8.7 18.8 1.8 7.3 1.7 2.2 2 0 0 2 2 2 0 Aluminium activated malate transporter DUF4045 PF13254.6 CDI85143.1 - 0.7 9.5 23.7 2 8.0 10.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) DUF1840 PF08895.11 CDI85143.1 - 0.72 10.2 29.4 2.5 8.5 3.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) SART-1 PF03343.13 CDI85143.1 - 0.88 8.1 28.6 0.44 9.0 3.6 2.1 2 0 0 2 2 2 0 SART-1 family PNISR PF15996.5 CDI85143.1 - 1.2 9.3 39.4 2.5 8.3 23.2 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR RMP PF14996.6 CDI85143.1 - 1.7 8.8 27.0 0.27 11.5 2.3 3.3 3 0 0 3 3 3 0 Retinal Maintenance Rtf2 PF04641.12 CDI85143.1 - 2.2 7.6 26.3 0.97 8.7 3.5 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger CNDH2_C PF16858.5 CDI85143.1 - 2.9 7.7 27.5 1.9 8.3 2.1 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PA26 PF04636.13 CDI85143.1 - 4.2 6.2 21.4 4.5 6.1 12.1 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Vfa1 PF08432.10 CDI85143.1 - 5.1 7.4 27.9 2.7 8.3 14.6 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Hydin_ADK PF17213.3 CDI85143.1 - 5.7 7.2 30.5 0.065 13.5 2.6 2.4 2 1 0 2 2 2 0 Hydin Adenylate kinase-like domain Peptidase_S49_N PF08496.10 CDI85143.1 - 6.4 6.8 27.1 2.9 8.0 1.8 3.2 3 0 0 3 3 3 0 Peptidase family S49 N-terminal RR_TM4-6 PF06459.12 CDI85143.1 - 7.2 6.4 36.7 0.38 10.5 15.9 2.4 2 1 0 2 2 2 0 Ryanodine Receptor TM 4-6 MAM33 PF02330.16 CDI85143.1 - 8.8 6.2 27.3 1.5 8.7 1.6 3.1 3 0 0 3 3 3 0 Mitochondrial glycoprotein MAS20 PF02064.15 CDI85144.1 - 0.0024 17.9 0.1 0.0024 17.9 0.1 1.1 1 0 0 1 1 1 1 MAS20 protein import receptor Sarcoglycan_2 PF05510.13 CDI85144.1 - 0.009 14.8 0.8 0.01 14.7 0.8 1.0 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon DUF4834 PF16118.5 CDI85144.1 - 0.018 16.0 0.2 0.02 15.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4199 PF13858.6 CDI85144.1 - 0.044 14.2 0.0 0.044 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) XPG_N PF00752.17 CDI85144.1 - 0.046 14.2 0.0 0.058 13.9 0.0 1.1 1 0 0 1 1 1 0 XPG N-terminal domain Phostensin_N PF13916.6 CDI85144.1 - 0.29 11.5 6.8 0.37 11.1 6.8 1.1 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Spt20 PF12090.8 CDI85144.1 - 0.34 10.5 12.5 0.39 10.3 12.5 1.1 1 0 0 1 1 1 0 Spt20 family Med3 PF11593.8 CDI85144.1 - 0.57 9.3 9.8 0.61 9.2 9.8 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF2722 PF10846.8 CDI85144.1 - 0.99 8.3 10.4 1.1 8.1 10.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pal1 PF08316.11 CDI85145.1 - 0.34 11.7 17.7 0.41 11.4 5.6 2.1 1 1 1 2 2 2 0 Pal1 cell morphology protein Draxin PF15550.6 CDI85145.1 - 0.6 9.9 23.2 0.64 9.8 23.2 1.1 1 0 0 1 1 1 0 Draxin DUF572 PF04502.13 CDI85145.1 - 7.1 6.1 28.3 9.7 5.7 28.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF3801 PF12687.7 CDI85146.1 - 0.0024 18.0 1.5 0.0024 18.0 1.5 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3801) PPL5 PF18168.1 CDI85146.1 - 0.29 10.4 10.3 0.04 13.2 1.6 2.2 2 0 0 2 2 2 0 Prim-pol family 5 Ribosomal_60s PF00428.19 CDI85146.1 - 1.3 9.7 29.4 1.1 9.9 1.9 3.9 3 1 0 3 3 3 0 60s Acidic ribosomal protein Rtt102p PF09510.10 CDI85146.1 - 2.9 8.1 7.8 0.59 10.3 3.7 1.8 2 0 0 2 2 2 0 Rtt102p-like transcription regulator protein FAM176 PF14851.6 CDI85146.1 - 5.7 6.6 12.8 0.35 10.5 6.7 2.1 2 0 0 2 2 2 0 FAM176 family Peptidase_S64 PF08192.11 CDI85146.1 - 8.3 4.8 19.5 12 4.3 19.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF2722 PF10846.8 CDI85147.1 - 0.00055 19.0 29.9 0.0042 16.1 22.7 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) THOC2_N PF16134.5 CDI85147.1 - 0.0027 16.4 3.9 0.0048 15.6 3.9 1.5 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus FAM60A PF15396.6 CDI85147.1 - 0.0066 16.5 2.6 0.017 15.1 2.6 1.7 1 0 0 1 1 1 1 Protein Family FAM60A DUF4834 PF16118.5 CDI85147.1 - 0.013 16.5 10.6 0.028 15.4 6.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CPSF100_C PF13299.6 CDI85147.1 - 0.013 15.7 4.8 0.013 15.7 4.8 2.4 2 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4175 PF13779.6 CDI85147.1 - 0.017 13.1 30.1 0.028 12.4 30.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Connexin PF00029.19 CDI85147.1 - 0.024 14.4 0.5 0.024 14.4 0.5 1.5 2 0 0 2 2 2 0 Connexin AIF_C PF14721.6 CDI85147.1 - 0.026 14.9 5.7 0.026 14.9 5.7 2.1 3 0 0 3 3 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Spt20 PF12090.8 CDI85147.1 - 0.049 13.2 46.0 0.043 13.4 1.5 2.1 2 0 0 2 2 2 0 Spt20 family Folate_carrier PF01770.18 CDI85147.1 - 0.081 11.6 0.8 0.14 10.9 0.8 1.4 1 0 0 1 1 1 0 Reduced folate carrier CSG2 PF16965.5 CDI85147.1 - 0.081 11.9 0.7 0.12 11.3 0.7 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator ABC2_membrane_2 PF12679.7 CDI85147.1 - 0.27 10.5 6.5 0.61 9.3 6.5 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein Myc_N PF01056.18 CDI85147.1 - 0.46 10.3 18.0 0.014 15.4 2.8 2.1 2 0 0 2 2 2 0 Myc amino-terminal region PAT1 PF09770.9 CDI85147.1 - 0.55 8.4 24.2 0.69 8.1 24.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EOS1 PF12326.8 CDI85147.1 - 1 9.3 4.4 0.31 11.0 1.6 1.6 2 0 0 2 2 1 0 N-glycosylation protein DUF4820 PF16091.5 CDI85147.1 - 1.4 8.2 17.3 0.93 8.8 10.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4820) RR_TM4-6 PF06459.12 CDI85147.1 - 1.5 8.6 11.0 0.2 11.4 6.8 1.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Rpp20 PF12328.8 CDI85147.1 - 2.1 8.3 13.1 13 5.7 0.1 2.3 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P G0-G1_switch_2 PF15103.6 CDI85147.1 - 2.2 8.7 10.5 15 6.1 6.8 2.5 2 0 0 2 2 2 0 G0/G1 switch protein 2 DUF3408 PF11888.8 CDI85147.1 - 2.5 8.2 11.9 0.83 9.8 7.7 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3408) DUF913 PF06025.12 CDI85147.1 - 3 6.7 11.6 0.8 8.6 8.6 1.5 1 1 1 2 2 2 0 Domain of Unknown Function (DUF913) MDM31_MDM32 PF08118.11 CDI85147.1 - 3.9 6.0 6.5 7.3 5.1 6.5 1.3 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Tim54 PF11711.8 CDI85147.1 - 4.4 6.0 19.4 4.4 6.0 14.2 2.1 1 1 1 2 2 2 0 Inner membrane protein import complex subunit Tim54 CAC1F_C PF16885.5 CDI85148.1 - 0.027 14.2 40.5 0.04 13.6 40.5 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term LAP1C PF05609.12 CDI85148.1 - 0.062 12.4 56.2 0.069 12.2 56.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GREB1 PF15782.5 CDI85148.1 - 0.52 7.4 51.7 0.58 7.2 51.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer BUD22 PF09073.10 CDI85149.1 - 2.4 7.4 35.6 2.6 7.3 35.6 1.0 1 0 0 1 1 1 0 BUD22 Activator_LAG-3 PF11498.8 CDI85153.1 - 5.4e-08 32.3 47.6 1.4e-07 30.9 39.5 2.3 2 0 0 2 2 2 2 Transcriptional activator LAG-3 SID-1_RNA_chan PF13965.6 CDI85153.1 - 0.64 8.4 9.7 1.1 7.6 9.7 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CDK5_activator PF03261.15 CDI85153.1 - 2.2 7.7 21.1 0.38 10.2 14.2 2.0 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein SOBP PF15279.6 CDI85153.1 - 8.5 6.9 29.9 3.5 8.2 20.1 2.2 2 0 0 2 2 2 0 Sine oculis-binding protein Pex14_N PF04695.13 CDI85156.1 - 0.0013 19.5 9.7 0.0016 19.1 9.7 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 CDI85156.1 - 0.0021 18.1 21.2 0.0023 18.0 21.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI85156.1 - 0.0048 15.9 19.4 0.0054 15.7 19.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Chloroplast_duf PF14476.6 CDI85156.1 - 0.0094 15.0 2.8 0.011 14.8 2.8 1.0 1 0 0 1 1 1 1 Petal formation-expressed Spt20 PF12090.8 CDI85156.1 - 0.0095 15.6 27.5 0.012 15.2 27.5 1.1 1 0 0 1 1 1 1 Spt20 family FAM176 PF14851.6 CDI85156.1 - 0.016 14.9 3.7 0.019 14.6 3.7 1.1 1 0 0 1 1 1 0 FAM176 family MMPL PF03176.15 CDI85156.1 - 0.018 14.0 8.4 0.02 13.8 8.4 1.0 1 0 0 1 1 1 0 MMPL family DUF3381 PF11861.8 CDI85156.1 - 0.024 14.5 15.0 0.033 14.0 15.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Afi1 PF07792.12 CDI85156.1 - 0.035 14.6 7.4 0.042 14.3 7.4 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DivIC PF04977.15 CDI85156.1 - 0.045 13.5 16.8 0.087 12.6 16.8 1.5 1 0 0 1 1 1 0 Septum formation initiator DUF4834 PF16118.5 CDI85156.1 - 0.061 14.3 10.5 0.093 13.7 10.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF5531 PF17671.1 CDI85156.1 - 0.072 13.0 1.0 0.1 12.4 1.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5531) SpoIIP PF07454.11 CDI85156.1 - 0.089 12.2 7.4 0.096 12.1 7.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CDI85156.1 - 0.1 11.4 7.2 0.11 11.3 7.2 1.1 1 0 0 1 1 1 0 Presenilin DUF1266 PF06889.11 CDI85156.1 - 0.12 12.4 10.8 0.15 12.1 10.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) DUF1943 PF09172.11 CDI85156.1 - 0.12 11.5 2.0 0.13 11.5 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) YjeJ PF15922.5 CDI85156.1 - 0.13 11.5 6.5 0.18 11.0 6.5 1.2 1 0 0 1 1 1 0 YjeJ-like MMR1 PF08505.10 CDI85156.1 - 0.17 12.2 8.9 0.18 12.0 8.9 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Connexin PF00029.19 CDI85156.1 - 0.17 11.6 3.7 0.19 11.5 3.7 1.1 1 0 0 1 1 1 0 Connexin CSG2 PF16965.5 CDI85156.1 - 0.18 10.7 4.3 0.21 10.5 4.3 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator PAT1 PF09770.9 CDI85156.1 - 0.22 9.8 14.0 0.23 9.7 14.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 CDI85156.1 - 0.22 10.5 7.3 0.23 10.4 7.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 EphA2_TM PF14575.6 CDI85156.1 - 0.22 12.4 2.7 0.43 11.5 2.7 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DDHD PF02862.17 CDI85156.1 - 0.22 11.6 6.0 0.24 11.5 6.0 1.2 1 0 0 1 1 1 0 DDHD domain OATP PF03137.20 CDI85156.1 - 0.24 9.7 1.9 0.26 9.5 1.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family MPM1 PF17234.2 CDI85156.1 - 0.24 11.6 10.2 0.34 11.2 10.2 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Neur_chan_memb PF02932.16 CDI85156.1 - 0.28 11.2 5.1 0.3 11.1 5.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Otopetrin PF03189.13 CDI85156.1 - 0.28 10.0 2.0 0.27 10.0 2.0 1.1 1 0 0 1 1 1 0 Otopetrin Gti1_Pac2 PF09729.9 CDI85156.1 - 0.28 11.2 5.0 0.29 11.2 5.0 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family CLN3 PF02487.17 CDI85156.1 - 0.31 10.0 6.8 0.36 9.8 6.8 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4746 PF15928.5 CDI85156.1 - 0.34 10.3 6.8 0.37 10.2 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) BAF1_ABF1 PF04684.13 CDI85156.1 - 0.37 9.8 11.8 0.45 9.5 11.8 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor UPF0560 PF10577.9 CDI85156.1 - 0.44 9.0 10.5 0.48 8.9 10.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 SID-1_RNA_chan PF13965.6 CDI85156.1 - 0.45 8.9 3.8 0.52 8.7 3.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Band_3_cyto PF07565.13 CDI85156.1 - 0.5 10.1 7.8 0.59 9.9 7.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TERB2 PF15101.6 CDI85156.1 - 0.64 10.0 12.8 0.75 9.8 12.8 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 FHIPEP PF00771.20 CDI85156.1 - 0.68 8.3 7.3 0.73 8.2 7.3 1.1 1 0 0 1 1 1 0 FHIPEP family eIF-3_zeta PF05091.12 CDI85156.1 - 0.69 8.8 11.7 0.82 8.6 11.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4366 PF14283.6 CDI85156.1 - 0.7 9.9 9.4 1 9.4 9.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) ABC2_membrane_2 PF12679.7 CDI85156.1 - 0.7 9.1 3.4 0.97 8.7 3.4 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein CPSF100_C PF13299.6 CDI85156.1 - 0.76 9.9 9.9 0.92 9.7 9.9 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF3292 PF11696.8 CDI85156.1 - 0.93 7.8 10.6 1.1 7.5 10.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) ALMT PF11744.8 CDI85156.1 - 0.94 8.2 6.8 1.1 8.1 6.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PIP5K PF01504.18 CDI85156.1 - 1.3 8.2 8.2 1.6 7.9 8.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase FAM150 PF15129.6 CDI85156.1 - 1.9 8.7 10.6 3.4 7.8 10.6 1.5 1 0 0 1 1 1 0 FAM150 family V_ATPase_I PF01496.19 CDI85156.1 - 1.9 6.3 11.3 2.3 6.0 11.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GREB1 PF15782.5 CDI85156.1 - 2 5.5 9.0 2.3 5.2 9.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF3708 PF12501.8 CDI85156.1 - 2 8.2 11.1 2.5 7.9 11.1 1.0 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter Sec62 PF03839.16 CDI85156.1 - 3.2 7.2 8.7 3.8 7.0 8.7 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Ndc1_Nup PF09531.10 CDI85156.1 - 3.3 6.3 9.3 3.9 6.0 9.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup OSTbeta PF15048.6 CDI85156.1 - 3.7 7.7 8.3 5.7 7.1 8.3 1.3 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein MDM10 PF12519.8 CDI85156.1 - 4.6 6.0 7.8 5 5.9 7.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Paramyxo_ncap PF00973.19 CDI85156.1 - 5.1 5.9 8.8 6.1 5.6 8.8 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF2572 PF10833.8 CDI85156.1 - 6.8 6.4 15.1 8.6 6.1 15.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) Endonuc_Holl PF10107.9 CDI85156.1 - 7.8 6.3 9.8 11 5.9 9.8 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase DUF4175 PF13779.6 CDI85156.1 - 8.1 4.2 31.3 10 3.9 31.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF2116 PF09889.9 CDI85157.1 - 2.5 8.1 5.5 4.7 7.3 5.5 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DnaJ PF00226.31 CDI85158.1 - 6.5e-08 32.6 0.0 3.8e-06 26.9 0.0 2.5 2 0 0 2 2 2 2 DnaJ domain Glycos_transf_2 PF00535.26 CDI85159.1 - 6.2e-25 88.0 0.0 1.1e-24 87.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 CDI85159.1 - 1.2e-11 44.9 0.0 2.2e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 CDI85159.1 - 1.1e-06 28.2 0.7 1.1e-05 25.0 0.1 2.4 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 CDI85159.1 - 0.001 19.0 0.0 0.0016 18.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 CDI85159.1 - 0.042 14.6 0.0 0.69 10.7 0.0 2.4 1 1 2 3 3 3 0 Ricin-type beta-trefoil lectin domain-like PAXIP1_C PF15364.6 CDI85162.1 - 0.17 12.2 3.7 0.3 11.4 3.7 1.3 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein Med15 PF09606.10 CDI85162.1 - 0.57 8.8 28.8 0.92 8.1 28.8 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF1631 PF07793.11 CDI85162.1 - 0.77 8.1 29.5 0.99 7.7 29.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) TFIIA PF03153.13 CDI85162.1 - 1.7 8.5 38.4 2.3 8.1 38.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FYDLN_acid PF09538.10 CDI85164.1 - 0.98 10.1 15.9 1.4 9.6 15.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) RNA_pol_Rpc4 PF05132.14 CDI85164.1 - 1.2 9.6 17.7 1.2 9.5 17.7 1.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 FAM176 PF14851.6 CDI85164.1 - 1.3 8.7 18.0 1.9 8.2 18.0 1.3 1 0 0 1 1 1 0 FAM176 family DUF5308 PF17233.2 CDI85164.1 - 1.7 8.9 16.1 1.8 8.7 16.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Afi1 PF07792.12 CDI85164.1 - 1.8 9.0 21.8 2 8.9 21.8 1.0 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PIP5K PF01504.18 CDI85164.1 - 1.9 7.7 18.5 1.8 7.7 18.5 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DDRGK PF09756.9 CDI85164.1 - 2.2 7.8 37.2 2.5 7.6 37.2 1.0 1 0 0 1 1 1 0 DDRGK domain SpoIIP PF07454.11 CDI85164.1 - 2.5 7.5 25.2 2.6 7.4 25.2 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Eapp_C PF10238.9 CDI85164.1 - 2.6 8.1 21.4 3.4 7.8 21.4 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF5523 PF17661.1 CDI85164.1 - 2.8 7.6 28.2 3.1 7.4 28.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) MMU163 PF17119.5 CDI85164.1 - 3.1 6.9 9.8 3.6 6.7 9.8 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Presenilin PF01080.17 CDI85164.1 - 3.2 6.4 26.0 3.5 6.3 26.0 1.0 1 0 0 1 1 1 0 Presenilin Velvet PF11754.8 CDI85164.1 - 3.4 7.5 17.8 3.6 7.5 17.8 1.0 1 0 0 1 1 1 0 Velvet factor TRAP_alpha PF03896.16 CDI85164.1 - 3.4 6.8 17.4 3.7 6.7 17.4 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Connexin PF00029.19 CDI85164.1 - 3.5 7.3 21.3 3.9 7.2 21.3 1.0 1 0 0 1 1 1 0 Connexin CPSF100_C PF13299.6 CDI85164.1 - 3.6 7.7 20.2 4.1 7.6 20.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CobT PF06213.12 CDI85164.1 - 3.9 6.8 36.7 4.2 6.7 36.7 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT V_ATPase_I PF01496.19 CDI85164.1 - 4 5.2 26.7 4.3 5.1 26.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 CDI85164.1 - 4.2 7.1 26.3 4.8 6.9 26.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Rtf2 PF04641.12 CDI85164.1 - 4.6 6.5 18.3 4.9 6.4 18.3 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger FAM60A PF15396.6 CDI85164.1 - 4.8 7.1 16.7 4.9 7.1 16.7 1.0 1 0 0 1 1 1 0 Protein Family FAM60A RPN2_C PF18004.1 CDI85164.1 - 5.7 6.8 25.3 6.7 6.6 25.3 1.0 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pinin_SDK_memA PF04696.13 CDI85164.1 - 5.7 7.0 36.5 6.7 6.8 36.5 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region DUF2052 PF09747.9 CDI85164.1 - 5.9 7.0 27.9 6.5 6.8 27.9 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CLN3 PF02487.17 CDI85164.1 - 6.1 5.8 19.1 6.7 5.6 19.1 1.0 1 0 0 1 1 1 0 CLN3 protein Pox_Ag35 PF03286.14 CDI85164.1 - 6.7 6.4 18.6 7.7 6.3 18.6 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Gti1_Pac2 PF09729.9 CDI85164.1 - 7 6.7 18.6 7.5 6.6 18.6 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family ATAD4 PF15321.6 CDI85164.1 - 7.7 7.9 14.9 12 7.4 14.9 1.3 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 CCDC53 PF10152.9 CDI85164.1 - 7.7 6.9 23.7 9.4 6.6 23.7 1.0 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF913 PF06025.12 CDI85164.1 - 8 5.3 18.8 9 5.2 18.8 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Tfb4 PF03850.14 CDI85164.1 - 8.3 5.8 13.1 8.5 5.8 13.1 1.0 1 0 0 1 1 1 0 Transcription factor Tfb4 DUF4746 PF15928.5 CDI85164.1 - 9 5.6 24.4 9.6 5.5 24.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CDC45 PF02724.14 CDI85164.1 - 9.6 4.4 24.1 11 4.1 24.1 1.0 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 CDI85164.1 - 9.8 6.6 13.5 15 6.1 13.5 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4637 PF15470.6 CDI85164.1 - 9.8 5.9 21.2 12 5.6 21.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF3408 PF11888.8 CDI85164.1 - 10 6.3 24.8 13 6.0 24.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) SIT PF15330.6 CDI85166.1 - 0.22 12.0 1.7 0.31 11.5 1.5 1.5 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF4746 PF15928.5 CDI85166.1 - 0.44 9.9 6.1 0.39 10.1 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DNA_pol_phi PF04931.13 CDI85166.1 - 0.46 8.5 8.6 0.42 8.7 8.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi MscS_TM PF12794.7 CDI85166.1 - 1.5 7.6 3.0 1.5 7.6 3.0 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 TRAP_alpha PF03896.16 CDI85166.1 - 1.8 7.7 5.7 2 7.5 5.7 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BUD22 PF09073.10 CDI85166.1 - 2.5 7.3 12.9 2.8 7.2 12.9 1.1 1 0 0 1 1 1 0 BUD22 PI3K_1B_p101 PF10486.9 CDI85166.1 - 3.6 5.3 8.2 4.2 5.0 8.2 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Merozoite_SPAM PF07133.11 CDI85166.1 - 8.2 6.4 20.2 11 6.0 20.2 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) SOBP PF15279.6 CDI85167.1 - 0.022 15.4 10.6 0.024 15.3 10.6 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein SLC12 PF03522.15 CDI85167.1 - 0.045 12.8 8.5 0.046 12.7 8.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF2052 PF09747.9 CDI85167.1 - 0.11 12.6 11.0 0.17 12.0 11.0 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Activator_LAG-3 PF11498.8 CDI85167.1 - 0.11 11.4 56.4 0.16 10.9 56.4 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SARAF PF06682.12 CDI85167.1 - 0.12 12.1 12.7 0.16 11.6 12.7 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Tau95_N PF17682.1 CDI85167.1 - 0.15 12.3 6.1 2.8 8.2 2.0 2.2 2 0 0 2 2 2 0 Tau95 Triple barrel domain Mgr1 PF08602.10 CDI85167.1 - 0.16 10.7 3.9 0.24 10.2 3.9 1.2 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit PIP5K PF01504.18 CDI85167.1 - 0.22 10.7 5.8 0.31 10.2 5.8 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Ribosomal_60s PF00428.19 CDI85167.1 - 0.6 10.7 30.1 3.5 8.3 1.3 4.0 2 1 1 3 3 3 0 60s Acidic ribosomal protein Dala_Dala_lig_N PF01820.21 CDI85167.1 - 0.68 10.4 2.7 5 7.6 2.7 2.1 1 1 0 1 1 1 0 D-ala D-ala ligase N-terminus COX16 PF14138.6 CDI85167.1 - 0.8 10.3 3.8 4.4 7.9 0.4 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 Hid1 PF12722.7 CDI85167.1 - 1 7.4 13.0 1.2 7.2 13.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PAT1 PF09770.9 CDI85167.1 - 1.1 7.4 27.4 1.4 7.1 27.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SWI-SNF_Ssr4 PF08549.10 CDI85167.1 - 1.7 7.2 20.5 2.5 6.6 20.5 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) GET2 PF08690.10 CDI85167.1 - 1.7 8.2 19.0 2.4 7.7 19.0 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Chorein_N PF12624.7 CDI85167.1 - 2 8.5 10.8 52 4.0 4.8 3.2 3 0 0 3 3 3 0 N-terminal region of Chorein or VPS13 V_ATPase_I PF01496.19 CDI85167.1 - 2.1 6.2 13.1 2.5 5.9 13.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4710 PF15828.5 CDI85167.1 - 2.2 8.5 8.2 3.5 7.8 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) RR_TM4-6 PF06459.12 CDI85167.1 - 2.3 8.0 12.6 3.7 7.3 12.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1772 PF08592.11 CDI85167.1 - 3 8.2 11.8 1.8 8.9 2.9 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF1772) Methyltransf_32 PF13679.6 CDI85167.1 - 6.7 6.7 19.8 1.6e+02 2.2 19.8 2.3 1 1 0 1 1 1 0 Methyltransferase domain RIFIN PF02009.16 CDI85167.1 - 6.8 6.5 15.3 11 5.8 15.3 1.3 1 0 0 1 1 1 0 Rifin ST7 PF04184.12 CDI85167.1 - 9.5 4.6 8.1 0.36 9.2 0.3 1.8 1 1 1 2 2 2 0 ST7 protein MH2 PF03166.14 CDI85167.1 - 10 6.3 15.4 13 5.9 7.5 2.2 2 0 0 2 2 2 0 MH2 domain TagA PF12561.8 CDI85168.1 - 0.38 11.2 0.0 0.38 11.2 0.0 3.1 2 1 1 3 3 3 0 ToxR activated gene A lipoprotein domain Utp14 PF04615.13 CDI85168.1 - 8.6 4.8 48.9 12 4.3 48.9 1.1 1 0 0 1 1 1 0 Utp14 protein DUF572 PF04502.13 CDI85169.1 - 2.6e-05 24.0 15.7 2.6e-05 24.0 15.7 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF4045 PF13254.6 CDI85169.1 - 4.3e-05 23.3 19.0 4.3e-05 23.3 19.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4045) Hid1 PF12722.7 CDI85169.1 - 0.0015 16.8 24.4 0.0016 16.7 24.4 1.1 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CDI85169.1 - 0.0018 17.2 37.3 0.0023 16.8 37.3 1.1 1 0 0 1 1 1 1 Presenilin CAC1F_C PF16885.5 CDI85169.1 - 0.0021 17.8 12.5 0.0022 17.7 12.5 1.2 1 0 0 1 1 1 1 Voltage-gated calcium channel subunit alpha, C-term SAGA-Tad1 PF12767.7 CDI85169.1 - 0.0032 17.2 18.1 0.0033 17.2 18.1 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit Zip PF02535.22 CDI85169.1 - 0.054 12.7 18.1 0.069 12.4 18.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Endostatin PF06482.11 CDI85169.1 - 0.076 12.5 24.7 0.11 12.0 24.7 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF4746 PF15928.5 CDI85169.1 - 0.092 12.1 27.2 0.13 11.7 27.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF2151 PF10221.9 CDI85169.1 - 0.12 11.0 17.3 0.14 10.8 17.3 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Exonuc_VII_L PF02601.15 CDI85169.1 - 0.14 11.7 25.1 0.13 11.8 25.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Smg8_Smg9 PF10220.9 CDI85169.1 - 0.23 9.7 27.8 0.27 9.5 27.8 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Asp-B-Hydro_N PF05279.11 CDI85169.1 - 0.66 10.0 30.6 0.87 9.6 30.6 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region GAGA_bind PF06217.12 CDI85169.1 - 0.74 10.0 25.3 1 9.6 25.3 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family RR_TM4-6 PF06459.12 CDI85169.1 - 0.86 9.4 39.9 1.3 8.8 39.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 WDCP PF15390.6 CDI85169.1 - 1.1 7.5 20.4 1.4 7.2 20.4 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family XRN_M PF17846.1 CDI85169.1 - 1.5 7.7 32.1 2 7.3 32.1 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Hamartin PF04388.12 CDI85169.1 - 1.8 7.1 29.3 2.2 6.9 29.3 1.1 1 0 0 1 1 1 0 Hamartin protein LMBR1 PF04791.16 CDI85169.1 - 2 7.2 14.3 2.2 7.1 14.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Rtf2 PF04641.12 CDI85169.1 - 3.3 7.0 32.5 5.3 6.3 32.5 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Auxin_canalis PF05703.11 CDI85169.1 - 4.4 7.2 13.4 6.9 6.5 13.4 1.3 1 0 0 1 1 1 0 Auxin canalisation AUX_IAA PF02309.16 CDI85169.1 - 5 6.9 22.7 7.7 6.3 22.7 1.3 1 0 0 1 1 1 0 AUX/IAA family FAM60A PF15396.6 CDI85169.1 - 5.2 7.0 33.8 2 8.3 31.2 1.5 2 0 0 2 2 2 0 Protein Family FAM60A NPR3 PF03666.13 CDI85169.1 - 5.7 5.6 38.9 8.4 5.0 38.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF5427 PF10310.9 CDI85169.1 - 6.3 5.6 38.6 9.5 5.0 38.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SLC12 PF03522.15 CDI85169.1 - 7.4 5.5 41.5 11 4.9 41.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 RskA PF10099.9 CDI85170.1 - 8.6e-05 22.9 64.4 0.057 13.7 8.2 4.8 2 1 1 4 4 4 3 Anti-sigma-K factor rskA DUF755 PF05501.11 CDI85170.1 - 0.01 16.1 11.1 0.01 16.1 11.1 3.9 3 1 0 3 3 3 0 Domain of unknown function (DUF755) DUF2868 PF11067.8 CDI85170.1 - 0.51 9.8 40.8 0.16 11.5 20.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2868) SR-25 PF10500.9 CDI85170.1 - 1.6 8.3 42.1 0.05 13.2 8.2 3.4 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein Herpes_pp85 PF04637.12 CDI85170.1 - 7 4.9 16.8 0.33 9.3 7.5 2.2 2 0 0 2 2 2 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF1003 PF06210.11 CDI85170.1 - 9.6 6.4 12.0 8.8 6.5 1.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1003) DUF2457 PF10446.9 CDI85171.1 - 0.00022 20.5 24.6 0.00028 20.2 24.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Nop53 PF07767.11 CDI85171.1 - 0.023 14.1 4.3 0.029 13.8 4.3 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) YL1 PF05764.13 CDI85171.1 - 0.023 14.8 13.9 0.028 14.5 13.9 1.1 1 0 0 1 1 1 0 YL1 nuclear protein CDC45 PF02724.14 CDI85171.1 - 0.024 12.9 11.4 0.029 12.7 11.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 CDI85171.1 - 0.025 12.7 18.0 0.028 12.6 18.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 CDI85171.1 - 0.09 11.0 14.8 0.097 10.9 14.8 1.1 1 0 0 1 1 1 0 Nop14-like family Apt1 PF10351.9 CDI85171.1 - 0.11 11.4 10.1 0.13 11.1 10.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SDA1 PF05285.12 CDI85171.1 - 0.24 10.8 19.8 0.29 10.5 19.8 1.2 1 0 0 1 1 1 0 SDA1 SARAF PF06682.12 CDI85171.1 - 0.54 9.9 3.9 0.63 9.6 3.9 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis SGT1 PF07093.11 CDI85171.1 - 2 6.8 6.6 2.5 6.4 6.6 1.2 1 0 0 1 1 1 0 SGT1 protein Lin-8 PF03353.15 CDI85171.1 - 2.9 7.4 11.3 3.6 7.0 11.3 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Macoilin PF09726.9 CDI85171.1 - 3.8 6.0 9.6 4.9 5.6 9.6 1.2 1 0 0 1 1 1 0 Macoilin family TFIIF_alpha PF05793.12 CDI85171.1 - 5.4 5.5 22.1 6.7 5.2 22.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Spt5_N PF11942.8 CDI85171.1 - 6.8 7.7 25.8 12 7.0 25.8 1.4 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Amidohydro_2 PF04909.14 CDI85171.1 - 7.4 6.3 12.6 8.7 6.0 12.6 1.0 1 0 0 1 1 1 0 Amidohydrolase DUF2722 PF10846.8 CDI85172.1 - 0.0038 16.2 16.5 0.0038 16.2 16.5 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Presenilin PF01080.17 CDI85172.1 - 0.053 12.3 17.8 0.058 12.1 17.8 1.1 1 0 0 1 1 1 0 Presenilin SOBP PF15279.6 CDI85172.1 - 0.068 13.8 19.6 0.078 13.6 19.6 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Gti1_Pac2 PF09729.9 CDI85172.1 - 0.093 12.8 12.3 0.11 12.6 12.3 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF913 PF06025.12 CDI85172.1 - 0.096 11.6 10.8 0.13 11.3 10.8 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) LAP1C PF05609.12 CDI85172.1 - 0.11 11.5 18.5 0.12 11.4 18.5 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Orf78 PF06024.12 CDI85172.1 - 0.14 12.4 15.6 0.084 13.2 1.8 2.2 2 0 0 2 2 2 0 Orf78 (ac78) CDC45 PF02724.14 CDI85172.1 - 0.2 9.9 11.8 0.23 9.7 11.8 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4050 PF13259.6 CDI85172.1 - 0.21 11.9 12.7 0.28 11.5 12.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Urate_ox_N PF06181.11 CDI85172.1 - 0.22 10.8 1.6 0.43 9.9 1.6 1.4 1 0 0 1 1 1 0 Urate oxidase N-terminal PIP5K PF01504.18 CDI85172.1 - 0.26 10.5 11.6 0.33 10.1 11.6 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Vac7 PF12751.7 CDI85172.1 - 0.29 10.5 6.2 0.4 10.1 6.2 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 CCSAP PF15748.5 CDI85172.1 - 0.3 11.2 16.2 0.4 10.8 16.2 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Tmemb_185A PF10269.9 CDI85172.1 - 0.31 10.7 0.4 0.41 10.3 0.4 1.4 1 1 0 1 1 1 0 Transmembrane Fragile-X-F protein Lin-8 PF03353.15 CDI85172.1 - 0.38 10.3 19.5 0.44 10.1 19.5 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RR_TM4-6 PF06459.12 CDI85172.1 - 0.42 10.4 16.1 0.54 10.0 16.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI85172.1 - 0.48 9.4 17.4 0.51 9.3 17.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 BAF1_ABF1 PF04684.13 CDI85172.1 - 0.49 9.4 13.9 0.65 9.0 13.9 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Membralin PF09746.9 CDI85172.1 - 0.49 9.4 6.1 0.52 9.3 6.1 1.2 1 0 0 1 1 1 0 Tumour-associated protein FAM60A PF15396.6 CDI85172.1 - 0.54 10.2 12.9 0.65 10.0 12.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A HCO3_cotransp PF00955.21 CDI85172.1 - 0.55 9.0 7.2 0.64 8.8 7.2 1.0 1 0 0 1 1 1 0 HCO3- transporter family GREB1 PF15782.5 CDI85172.1 - 0.6 7.2 14.3 0.58 7.2 14.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 CDI85172.1 - 0.7 8.0 15.0 0.7 7.9 15.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ctr PF04145.15 CDI85172.1 - 0.79 10.3 9.8 1.1 9.9 9.8 1.4 1 0 0 1 1 1 0 Ctr copper transporter family Rtf2 PF04641.12 CDI85172.1 - 0.98 8.7 17.0 1.2 8.4 17.0 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Sin_N PF04801.13 CDI85172.1 - 1.3 8.2 27.5 1.5 8.0 27.5 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region BORG_CEP PF14957.6 CDI85172.1 - 1.4 10.1 13.9 2.2 9.4 13.9 1.3 1 0 0 1 1 1 0 Cdc42 effector Otopetrin PF03189.13 CDI85172.1 - 1.8 7.3 8.8 2 7.2 8.8 1.1 1 0 0 1 1 1 0 Otopetrin Ribosomal_60s PF00428.19 CDI85172.1 - 1.8 9.2 9.9 4.2 8.0 9.9 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein ALMT PF11744.8 CDI85172.1 - 2.3 7.0 13.4 2.6 6.8 13.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 CDI85172.1 - 2.3 8.2 13.2 3 7.8 13.2 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sec62 PF03839.16 CDI85172.1 - 2.3 7.7 14.7 3.1 7.2 14.7 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Spc7_N PF15402.6 CDI85172.1 - 2.6 6.2 13.9 3.7 5.7 13.9 1.3 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 CLN3 PF02487.17 CDI85172.1 - 3.8 6.4 14.6 4.7 6.2 14.6 1.2 1 0 0 1 1 1 0 CLN3 protein MDM10 PF12519.8 CDI85172.1 - 3.9 6.2 13.5 4.5 6.0 13.5 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CAF1 PF04857.20 CDI85172.1 - 4.9 6.2 12.2 6.3 5.9 12.2 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease PAT1 PF09770.9 CDI85172.1 - 5 5.3 38.6 5.5 5.1 38.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Abhydrolase_9_N PF15420.6 CDI85172.1 - 5.5 6.9 12.7 2.9 7.8 9.4 1.9 1 1 1 2 2 2 0 Alpha/beta-hydrolase family N-terminus Serinc PF03348.15 CDI85172.1 - 6 5.7 8.9 8 5.3 8.9 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) PNISR PF15996.5 CDI85172.1 - 9 6.5 27.9 15 5.8 27.9 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF2828 PF11443.8 CDI85172.1 - 9.2 4.2 18.8 11 3.9 18.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) RskA PF10099.9 CDI85173.1 - 7e-06 26.5 2.4 7e-06 26.5 2.4 3.3 1 1 2 3 3 3 2 Anti-sigma-K factor rskA Utp14 PF04615.13 CDI85173.1 - 0.11 11.0 23.0 0.15 10.6 23.0 1.1 1 0 0 1 1 1 0 Utp14 protein Lin-8 PF03353.15 CDI85173.1 - 0.15 11.6 24.5 0.038 13.6 10.8 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Sin_N PF04801.13 CDI85173.1 - 0.49 9.5 31.6 0.13 11.4 11.3 2.2 2 0 0 2 2 2 0 Sin-like protein conserved region GET2 PF08690.10 CDI85173.1 - 1 9.0 24.5 1.4 8.5 8.3 2.2 2 0 0 2 2 2 0 GET complex subunit GET2 DUF3347 PF11827.8 CDI85173.1 - 1.1 9.4 22.6 1.4 9.0 6.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) DUF1387 PF07139.11 CDI85173.1 - 1.3 8.7 23.2 0.2 11.3 6.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) DUF3995 PF13160.6 CDI85173.1 - 8.7 6.7 18.0 1.5 9.2 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3995) ANAPC1 PF12859.7 CDI85174.1 - 0.053 14.1 0.9 0.072 13.7 0.9 1.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 1 Abhydrolase_1 PF00561.20 CDI85174.1 - 0.12 12.0 1.5 0.17 11.5 1.5 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold RskA PF10099.9 CDI85174.1 - 0.24 11.7 20.0 2.5 8.4 12.7 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF4179 PF13786.6 CDI85174.1 - 0.61 10.6 11.7 0.39 11.2 2.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) R_equi_Vir PF05526.11 CDI85174.1 - 1.4 8.7 9.3 0.83 9.5 0.3 2.0 2 0 0 2 2 2 0 Rhodococcus equi virulence-associated protein Shadoo PF14999.6 CDI85174.1 - 1.9 8.6 17.5 3.5 7.7 2.4 2.3 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Menin PF05053.13 CDI85174.1 - 6.3 5.0 11.2 7.4 4.8 11.2 1.0 1 0 0 1 1 1 0 Menin PTPRCAP PF15713.5 CDI85175.1 - 5.5 7.3 21.5 7 6.9 21.5 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CSRNP_N PF16019.5 CDI85175.1 - 6.7 6.6 17.8 7.5 6.4 17.8 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus VIT1 PF01988.19 CDI85175.1 - 8.8 6.1 11.4 10 5.9 11.4 1.0 1 0 0 1 1 1 0 VIT family RskA PF10099.9 CDI85176.1 - 0.013 15.8 6.2 0.013 15.8 6.2 7.0 2 2 3 5 5 5 0 Anti-sigma-K factor rskA Chromo PF00385.24 CDI85179.1 - 2.5e-14 52.9 0.0 6e-14 51.7 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 CDI85179.1 - 3.2e-12 46.7 0.1 1.4e-11 44.6 0.0 2.2 2 1 1 3 3 3 1 Integrase core domain RT_RNaseH_2 PF17919.1 CDI85179.1 - 3.1e-05 23.9 0.0 8.7e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI85179.1 - 3.8e-05 23.9 0.0 0.00012 22.4 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF5523 PF17661.1 CDI85180.1 - 0.0012 18.7 9.2 0.0012 18.7 9.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5523) V_ATPase_I PF01496.19 CDI85180.1 - 0.0033 15.4 20.2 0.004 15.2 20.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family EOS1 PF12326.8 CDI85180.1 - 0.0062 16.5 10.3 0.0074 16.2 10.3 1.1 1 0 0 1 1 1 1 N-glycosylation protein Peptidase_S15 PF02129.18 CDI85180.1 - 0.0074 15.9 18.7 0.0078 15.8 18.7 1.0 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) DUF913 PF06025.12 CDI85180.1 - 0.0087 15.1 10.0 0.0093 15.0 10.0 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) SID-1_RNA_chan PF13965.6 CDI85180.1 - 0.0095 14.4 5.7 0.01 14.3 5.7 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DDHD PF02862.17 CDI85180.1 - 0.011 15.9 16.5 0.014 15.6 16.5 1.1 1 0 0 1 1 1 0 DDHD domain TERB2 PF15101.6 CDI85180.1 - 0.012 15.7 20.5 0.015 15.4 20.5 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Serinc PF03348.15 CDI85180.1 - 0.013 14.5 10.6 0.014 14.3 10.6 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) SpoIIP PF07454.11 CDI85180.1 - 0.014 14.9 16.4 0.016 14.7 16.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) GNAT_acetyltr_2 PF13718.6 CDI85180.1 - 0.016 14.6 12.3 0.021 14.3 12.3 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 eIF-3_zeta PF05091.12 CDI85180.1 - 0.017 14.1 22.3 0.018 14.1 22.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CLN3 PF02487.17 CDI85180.1 - 0.019 14.0 11.5 0.02 13.9 11.5 1.2 1 0 0 1 1 1 0 CLN3 protein DcuA_DcuB PF03605.14 CDI85180.1 - 0.02 13.8 8.0 0.03 13.2 8.0 1.3 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Tim54 PF11711.8 CDI85180.1 - 0.025 13.4 15.8 0.038 12.8 15.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Connexin PF00029.19 CDI85180.1 - 0.032 14.0 14.7 0.041 13.6 14.7 1.1 1 0 0 1 1 1 0 Connexin CSG2 PF16965.5 CDI85180.1 - 0.035 13.1 8.5 0.036 13.0 8.5 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Presenilin PF01080.17 CDI85180.1 - 0.035 12.9 22.7 0.038 12.8 22.7 1.1 1 0 0 1 1 1 0 Presenilin DUF2126 PF09899.9 CDI85180.1 - 0.035 12.2 10.9 0.036 12.2 10.9 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) PIEZO PF15917.5 CDI85180.1 - 0.038 13.5 18.9 0.044 13.3 18.9 1.1 1 0 0 1 1 1 0 Piezo FAM60A PF15396.6 CDI85180.1 - 0.044 13.8 12.0 0.048 13.7 12.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Neur_chan_memb PF02932.16 CDI85180.1 - 0.049 13.7 12.0 0.053 13.6 12.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2828 PF11443.8 CDI85180.1 - 0.052 11.6 16.2 0.055 11.5 16.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Endostatin PF06482.11 CDI85180.1 - 0.073 12.5 18.2 0.081 12.4 18.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin RR_TM4-6 PF06459.12 CDI85180.1 - 0.075 12.9 19.1 0.088 12.6 19.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2298 PF10060.9 CDI85180.1 - 0.081 11.6 4.7 0.098 11.4 4.7 1.2 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) Ctr PF04145.15 CDI85180.1 - 0.081 13.5 12.7 0.098 13.3 12.7 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Ribosomal_S2 PF00318.20 CDI85180.1 - 0.084 12.1 5.8 0.093 11.9 5.8 1.1 1 0 0 1 1 1 0 Ribosomal protein S2 SLC12 PF03522.15 CDI85180.1 - 0.086 11.9 17.0 0.088 11.8 17.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 CDI85180.1 - 0.1 10.9 14.2 0.12 10.6 14.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Pkinase_fungal PF17667.1 CDI85180.1 - 0.11 11.3 8.3 0.11 11.2 8.3 1.1 1 0 0 1 1 1 0 Fungal protein kinase BAF1_ABF1 PF04684.13 CDI85180.1 - 0.13 11.3 21.8 0.18 10.9 21.8 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor MSP1_C PF07462.11 CDI85180.1 - 0.14 10.9 9.9 0.16 10.7 9.9 1.0 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus CobT PF06213.12 CDI85180.1 - 0.16 11.3 29.4 0.21 10.9 29.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT OATP PF03137.20 CDI85180.1 - 0.17 10.2 7.0 0.2 9.9 7.0 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family TFB6 PF17110.5 CDI85180.1 - 0.19 11.5 9.6 0.33 10.7 9.6 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Peptidase_S49_N PF08496.10 CDI85180.1 - 0.19 11.8 15.3 0.27 11.3 15.3 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Pannexin_like PF12534.8 CDI85180.1 - 0.19 10.8 10.7 0.2 10.7 10.7 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 PPL5 PF18168.1 CDI85180.1 - 0.21 10.9 11.1 0.22 10.8 11.1 1.2 1 0 0 1 1 1 0 Prim-pol family 5 LMBR1 PF04791.16 CDI85180.1 - 0.21 10.4 8.6 0.2 10.5 8.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein TFIIA PF03153.13 CDI85180.1 - 0.22 11.5 57.5 0.39 10.7 57.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BORG_CEP PF14957.6 CDI85180.1 - 0.22 12.7 10.6 0.25 12.5 10.6 1.2 1 0 0 1 1 1 0 Cdc42 effector SART-1 PF03343.13 CDI85180.1 - 0.35 9.4 22.7 0.42 9.1 22.7 1.1 1 0 0 1 1 1 0 SART-1 family Baculo_PP31 PF05311.11 CDI85180.1 - 0.36 10.3 14.9 0.39 10.2 14.9 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) EIF4E-T PF10477.9 CDI85180.1 - 0.37 9.6 28.3 0.41 9.4 28.3 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Draxin PF15550.6 CDI85180.1 - 0.4 10.5 14.1 0.46 10.3 14.1 1.1 1 0 0 1 1 1 0 Draxin DUF1980 PF09323.10 CDI85180.1 - 0.4 10.6 12.4 0.54 10.1 12.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF4578 PF15147.6 CDI85180.1 - 0.47 11.3 27.0 0.79 10.6 27.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4578) DUF1387 PF07139.11 CDI85180.1 - 0.47 10.1 17.7 0.51 10.0 17.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) FAM176 PF14851.6 CDI85180.1 - 0.49 10.1 10.9 0.72 9.5 10.9 1.3 1 0 0 1 1 1 0 FAM176 family Velvet PF11754.8 CDI85180.1 - 0.52 10.2 19.9 0.61 10.0 19.9 1.1 1 0 0 1 1 1 0 Velvet factor DUF3295 PF11702.8 CDI85180.1 - 0.53 9.6 18.0 0.59 9.4 18.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Het-C PF07217.11 CDI85180.1 - 0.54 8.7 10.5 0.6 8.6 10.5 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C ALMT PF11744.8 CDI85180.1 - 0.54 9.0 15.4 0.58 8.9 15.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter NEMP PF10225.9 CDI85180.1 - 0.6 9.7 9.0 0.72 9.5 9.0 1.1 1 0 0 1 1 1 0 NEMP family CCDC71L PF15374.6 CDI85180.1 - 0.61 9.3 19.6 0.7 9.1 19.6 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L AMP-binding PF00501.28 CDI85180.1 - 0.63 8.6 8.8 0.74 8.3 8.8 1.0 1 0 0 1 1 1 0 AMP-binding enzyme MIIP PF15734.5 CDI85180.1 - 0.71 9.3 16.1 0.8 9.1 16.1 1.0 1 0 0 1 1 1 0 Migration and invasion-inhibitory Afi1 PF07792.12 CDI85180.1 - 0.71 10.4 18.0 0.92 10.0 18.0 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking LAP1C PF05609.12 CDI85180.1 - 0.88 8.6 22.4 0.98 8.4 22.4 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) MMR1 PF08505.10 CDI85180.1 - 0.92 9.8 23.8 1.2 9.3 23.8 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein HCO3_cotransp PF00955.21 CDI85180.1 - 0.95 8.2 7.4 1 8.1 7.4 1.1 1 0 0 1 1 1 0 HCO3- transporter family Membralin PF09746.9 CDI85180.1 - 0.97 8.4 12.7 1.1 8.2 12.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein AF-4 PF05110.13 CDI85180.1 - 1.1 7.3 25.8 1.2 7.2 25.8 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF2464 PF10240.9 CDI85180.1 - 1.1 8.8 11.9 1.2 8.7 11.9 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 Peptidase_S64 PF08192.11 CDI85180.1 - 1.1 7.7 17.0 1.4 7.3 17.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 Sec62 PF03839.16 CDI85180.1 - 1.1 8.7 14.9 1.5 8.3 14.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 FAM76 PF16046.5 CDI85180.1 - 1.2 8.4 21.6 1.6 8.0 21.6 1.1 1 0 0 1 1 1 0 FAM76 protein Macoilin PF09726.9 CDI85180.1 - 1.3 7.5 17.5 1.6 7.2 17.5 1.1 1 0 0 1 1 1 0 Macoilin family Peptidase_U57 PF05582.12 CDI85180.1 - 1.4 8.2 12.7 1.6 7.9 12.7 1.1 1 0 0 1 1 1 0 YabG peptidase U57 PAT1 PF09770.9 CDI85180.1 - 1.5 7.0 39.9 1.8 6.8 39.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SelP_N PF04592.14 CDI85180.1 - 1.5 8.1 23.7 1.9 7.8 23.7 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CCSAP PF15748.5 CDI85180.1 - 1.7 8.8 24.2 2.1 8.4 24.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated XRN_M PF17846.1 CDI85180.1 - 1.7 7.5 11.8 2.1 7.2 11.8 1.3 1 0 0 1 1 1 0 Xrn1 helical domain PIP5K PF01504.18 CDI85180.1 - 1.7 7.8 19.2 2.3 7.4 19.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF3405 PF11885.8 CDI85180.1 - 1.8 7.1 16.3 2.3 6.7 16.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) Nucleoside_tran PF01733.18 CDI85180.1 - 1.8 7.9 4.8 1.9 7.8 4.8 1.1 1 0 0 1 1 1 0 Nucleoside transporter Maf1 PF09174.10 CDI85180.1 - 1.9 8.6 11.9 2.6 8.2 11.9 1.2 1 0 0 1 1 1 0 Maf1 regulator Hamartin PF04388.12 CDI85180.1 - 2.1 6.9 19.1 2.3 6.8 19.1 1.0 1 0 0 1 1 1 0 Hamartin protein PBP1_TM PF14812.6 CDI85180.1 - 2.1 8.8 7.9 3.3 8.1 7.9 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal EFTUD2 PF16004.5 CDI85180.1 - 2.1 8.9 20.8 3.9 8.1 20.8 1.4 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Hid1 PF12722.7 CDI85180.1 - 2.2 6.3 19.3 2.2 6.3 19.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Band_3_cyto PF07565.13 CDI85180.1 - 2.2 8.0 20.4 2.8 7.7 20.4 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain O-antigen_lig PF13425.6 CDI85180.1 - 2.2 7.0 9.0 2.5 6.8 9.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Lin-8 PF03353.15 CDI85180.1 - 2.3 7.7 23.8 2.7 7.5 23.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF3984 PF13136.6 CDI85180.1 - 2.3 7.5 17.4 2.7 7.3 17.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) Cellulose_synt PF03552.14 CDI85180.1 - 2.4 6.5 6.6 2.6 6.4 6.6 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF572 PF04502.13 CDI85180.1 - 2.5 7.7 19.6 2.9 7.4 19.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) HemX PF04375.14 CDI85180.1 - 2.6 7.2 47.6 3.3 6.9 47.6 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase NPR3 PF03666.13 CDI85180.1 - 2.7 6.7 18.9 3.3 6.4 18.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 EMC3_TMCO1 PF01956.16 CDI85180.1 - 2.7 7.7 17.2 3.4 7.4 17.2 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Plasmodium_Vir PF05795.11 CDI85180.1 - 2.9 7.2 9.5 2.9 7.2 9.5 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF853 PF05872.12 CDI85180.1 - 3.3 6.2 16.9 4.4 5.8 16.9 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) SARAF PF06682.12 CDI85180.1 - 3.8 7.1 18.2 4.8 6.7 18.2 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Paf1 PF03985.13 CDI85180.1 - 3.9 6.4 23.5 4.8 6.1 23.5 1.1 1 0 0 1 1 1 0 Paf1 FliP PF00813.20 CDI85180.1 - 4.4 7.1 10.5 4.9 7.0 10.5 1.2 1 0 0 1 1 1 0 FliP family DUF4746 PF15928.5 CDI85180.1 - 4.7 6.5 15.2 6.6 6.1 15.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Paramyxo_ncap PF00973.19 CDI85180.1 - 5.1 5.9 15.5 5.7 5.7 15.5 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF4045 PF13254.6 CDI85180.1 - 5.3 6.6 22.4 6.2 6.4 22.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF4638 PF15472.6 CDI85180.1 - 5.4 6.7 17.8 7.4 6.2 17.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) MMM1 PF10296.9 CDI85180.1 - 5.7 5.9 13.3 7.3 5.5 13.3 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 TCP PF03634.13 CDI85180.1 - 6.2 7.4 25.0 8.3 7.0 25.0 1.1 1 0 0 1 1 1 0 TCP family transcription factor RIC3 PF15361.6 CDI85180.1 - 6.6 7.1 19.3 6.7 7.1 18.4 1.4 1 1 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 PRC2_HTH_1 PF18118.1 CDI85180.1 - 7.1 7.5 15.0 13 6.7 15.0 1.4 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Otopetrin PF03189.13 CDI85180.1 - 7.4 5.3 14.1 9.2 5.0 14.1 1.1 1 0 0 1 1 1 0 Otopetrin DUF2347 PF09804.9 CDI85180.1 - 7.9 6.0 12.0 8.9 5.8 12.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF1943 PF09172.11 CDI85180.1 - 8.3 5.5 13.4 11 5.1 13.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Peroxin-3 PF04882.12 CDI85180.1 - 9.1 5.1 23.6 11 4.9 23.6 1.0 1 0 0 1 1 1 0 Peroxin-3 PGM_PMM_I PF02878.16 CDI85181.1 - 4.2e-12 46.0 0.0 5.7e-06 26.1 0.0 2.4 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I N6_N4_Mtase PF01555.18 CDI85181.1 - 0.00053 19.8 0.0 0.06 13.1 0.0 3.0 1 1 0 1 1 1 1 DNA methylase PGA2 PF07543.12 CDI85181.1 - 0.0058 16.6 6.7 0.0058 16.6 6.7 3.4 3 0 0 3 3 3 1 Protein trafficking PGA2 DUF4834 PF16118.5 CDI85181.1 - 0.0065 17.4 2.6 0.0065 17.4 2.6 4.7 4 1 1 5 5 4 2 Domain of unknown function (DUF4834) YceD PF02620.17 CDI85181.1 - 0.0085 16.2 5.4 0.0085 16.2 5.4 3.2 3 0 0 3 3 3 1 Large ribosomal RNA subunit accumulation protein YceD MPM1 PF17234.2 CDI85181.1 - 0.016 15.5 0.6 0.016 15.5 0.6 4.3 3 1 1 4 4 3 0 Mitochondrial peculiar membrane protein 1 DUF4064 PF13273.6 CDI85181.1 - 0.022 15.0 0.1 0.022 15.0 0.1 4.7 4 1 0 4 4 3 0 Protein of unknown function (DUF4064) YABBY PF04690.13 CDI85181.1 - 0.023 15.2 3.5 0.023 15.2 3.5 3.7 2 1 0 3 3 2 0 YABBY protein Neur_chan_memb PF02932.16 CDI85181.1 - 0.038 14.0 25.7 0.15 12.1 6.3 3.2 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region DUF4225 PF13988.6 CDI85181.1 - 0.047 13.3 0.1 0.14 11.7 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4225) Thg1C PF14413.6 CDI85181.1 - 0.18 12.0 34.4 0.51 10.5 11.4 3.5 3 0 0 3 3 3 0 Thg1 C terminal domain V_ATPase_I PF01496.19 CDI85181.1 - 0.85 7.5 37.6 0.97 7.3 4.4 3.1 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family Isy1 PF06246.12 CDI85181.1 - 0.9 9.1 33.4 1.2 8.6 3.0 3.3 3 0 0 3 3 3 0 Isy1-like splicing family DUF4667 PF15700.5 CDI85181.1 - 1.1 9.3 30.0 1.6 8.8 2.3 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4667) DUF3899 PF13038.6 CDI85181.1 - 1.3 9.6 3.2 13 6.3 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF3899) DUF2076 PF09849.9 CDI85181.1 - 1.4 8.9 71.5 0.5 10.4 10.9 3.4 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2076) tRNA_synt_1c_R2 PF04557.15 CDI85181.1 - 1.7 9.6 32.7 5 8.1 4.7 4.4 4 0 0 4 4 4 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 ArsP_2 PF11449.8 CDI85181.1 - 2.1 7.5 17.7 0.89 8.7 3.4 3.3 1 1 2 3 3 3 0 Putative, 10TM heavy-metal exporter OAD_gamma PF04277.13 CDI85181.1 - 3.3 8.4 0.0 3.3 8.4 0.0 4.4 5 1 0 5 5 5 0 Oxaloacetate decarboxylase, gamma chain CDC27 PF09507.10 CDI85181.1 - 4 6.7 31.6 0.7 9.2 7.5 3.1 3 0 0 3 3 3 0 DNA polymerase subunit Cdc27 EST1 PF10374.9 CDI85181.1 - 5.8 7.6 31.9 6.5 7.4 4.1 3.5 3 0 0 3 3 3 0 Telomerase activating protein Est1 CCDC53 PF10152.9 CDI85181.1 - 8.7 6.7 43.2 1.1 9.7 2.7 4.0 3 1 0 3 3 3 0 Subunit CCDC53 of WASH complex DUF2244 PF10003.9 CDI85182.1 - 0.001 18.7 3.4 0.001 18.7 3.4 1.7 1 1 1 2 2 2 1 Integral membrane protein (DUF2244) TMEM51 PF15345.6 CDI85182.1 - 0.011 15.6 7.5 0.011 15.6 7.5 1.5 1 1 0 1 1 1 0 Transmembrane protein 51 RSN1_TM PF13967.6 CDI85182.1 - 0.016 15.0 0.7 0.021 14.6 0.7 1.3 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport CLN3 PF02487.17 CDI85182.1 - 0.017 14.2 3.2 0.018 14.1 3.2 1.0 1 0 0 1 1 1 0 CLN3 protein Glyco_hydro_9 PF00759.19 CDI85182.1 - 0.021 14.3 1.3 0.022 14.2 1.3 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 DUF2621 PF11084.8 CDI85182.1 - 0.032 14.2 0.3 0.038 14.0 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2621) Ribosomal_60s PF00428.19 CDI85182.1 - 0.058 14.0 7.1 0.078 13.6 7.1 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Neur_chan_memb PF02932.16 CDI85182.1 - 0.12 12.4 2.7 0.16 12.0 2.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SARAF PF06682.12 CDI85182.1 - 0.12 12.0 0.4 0.16 11.6 0.4 1.3 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis WBP-1 PF11669.8 CDI85182.1 - 0.14 12.8 1.1 0.21 12.2 1.1 1.3 1 0 0 1 1 1 0 WW domain-binding protein 1 TALPID3 PF15324.6 CDI85182.1 - 0.28 8.8 9.2 0.37 8.4 9.2 1.1 1 0 0 1 1 1 0 Hedgehog signalling target TMEM61 PF15105.6 CDI85182.1 - 0.56 10.0 5.7 8.7 6.1 1.9 2.1 1 1 1 2 2 2 0 TMEM61 protein family Activator_LAG-3 PF11498.8 CDI85182.1 - 0.94 8.4 18.1 1.1 8.1 18.1 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF1430 PF07242.11 CDI85182.1 - 1.5 9.1 10.7 3 8.2 10.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1430) DUF3138 PF11336.8 CDI85182.1 - 2.8 6.5 10.8 3.2 6.2 10.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Spt20 PF12090.8 CDI85182.1 - 5.7 6.5 13.8 7 6.2 13.8 1.1 1 0 0 1 1 1 0 Spt20 family MAP17 PF15807.5 CDI85183.1 - 0.057 13.6 0.3 0.098 12.9 0.3 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 VWA_2 PF13519.6 CDI85183.1 - 0.097 13.3 0.3 0.097 13.3 0.3 1.8 2 0 0 2 2 2 0 von Willebrand factor type A domain YajC PF02699.15 CDI85183.1 - 0.25 11.2 0.5 0.62 10.0 0.5 1.7 1 0 0 1 1 1 0 Preprotein translocase subunit RBM39linker PF15519.6 CDI85183.1 - 1.6 9.8 4.9 1.9 9.7 2.7 2.3 2 1 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein DUF3824 PF12868.7 CDI85184.1 - 0.041 14.5 10.4 0.051 14.2 10.4 1.1 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) RskA PF10099.9 CDI85184.1 - 0.055 13.8 17.3 0.065 13.5 17.3 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA O-antigen_lig PF13425.6 CDI85184.1 - 2.1 7.0 3.0 2 7.1 3.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein BAF1_ABF1 PF04684.13 CDI85184.1 - 3.2 6.7 15.5 3.5 6.6 15.5 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor R_equi_Vir PF05526.11 CDI85184.1 - 3.9 7.3 8.5 4 7.3 8.5 1.0 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF1764 PF08576.10 CDI85184.1 - 4.1 8.4 14.8 5.5 8.0 14.8 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) IHABP4_N PF16174.5 CDI85184.1 - 6.8 7.3 24.2 7.5 7.1 24.2 1.0 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal ATAD4 PF15321.6 CDI85184.1 - 9.8 7.6 12.5 13 7.2 12.5 1.2 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 eIF-3_zeta PF05091.12 CDI85185.1 - 1.7e-07 30.6 16.1 2.7e-07 30.0 16.1 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI85185.1 - 0.0031 17.6 45.5 0.0031 17.6 45.5 2.2 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 CDI85185.1 - 0.84 9.4 24.9 1.6 8.5 24.9 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI85185.1 - 1.1 8.0 30.1 2.3 6.9 30.1 1.5 1 0 0 1 1 1 0 Presenilin PIP5K PF01504.18 CDI85185.1 - 1.5 8.0 14.2 4 6.6 14.2 1.7 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase CPSF100_C PF13299.6 CDI85185.1 - 2.2 8.4 16.9 7.5 6.7 16.9 2.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Neur_chan_memb PF02932.16 CDI85185.1 - 3.4 7.6 18.5 13 5.8 18.5 1.9 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MDM10 PF12519.8 CDI85185.1 - 4.1 6.2 19.7 7.2 5.4 19.7 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF5352 PF17303.2 CDI85185.1 - 5.2 6.9 11.5 10 5.9 11.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5352) PAT1 PF09770.9 CDI85185.1 - 5.7 5.1 35.6 9.6 4.3 35.6 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 N2227 PF07942.12 CDI85186.1 - 0.051 12.8 0.0 0.098 11.8 0.0 1.4 1 0 0 1 1 1 0 N2227-like protein Presenilin PF01080.17 CDI85188.1 - 8.9 5.0 23.2 11 4.7 23.2 1.0 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 CDI85189.1 - 0.016 14.9 20.9 0.019 14.6 20.9 1.1 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI85189.1 - 0.017 15.1 21.7 0.02 14.9 21.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 CDI85189.1 - 0.027 13.5 3.0 0.027 13.5 3.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2722 PF10846.8 CDI85189.1 - 0.048 12.6 16.9 0.063 12.2 16.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) FHIPEP PF00771.20 CDI85189.1 - 0.056 11.9 2.9 0.065 11.7 2.9 1.1 1 0 0 1 1 1 0 FHIPEP family Presenilin PF01080.17 CDI85189.1 - 0.064 12.0 2.6 0.067 11.9 2.6 1.1 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CDI85189.1 - 0.08 12.9 6.8 0.08 12.9 6.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Med15 PF09606.10 CDI85189.1 - 0.13 11.0 20.4 0.16 10.7 20.4 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TERB2 PF15101.6 CDI85189.1 - 0.43 10.6 8.0 0.52 10.3 8.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 PAT1 PF09770.9 CDI85189.1 - 1.2 7.4 12.5 1.3 7.2 12.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DivIC PF04977.15 CDI85189.1 - 5.8 6.8 12.2 8.5 6.2 12.2 1.3 1 0 0 1 1 1 0 Septum formation initiator Conotoxin PF02950.17 CDI85189.1 - 7.4 7.7 0.0 7.4 7.7 0.0 2.5 2 1 0 2 2 2 0 Conotoxin DUF4834 PF16118.5 CDI85189.1 - 9.1 7.3 12.0 0.41 11.6 6.9 1.4 2 0 0 2 2 1 0 Domain of unknown function (DUF4834) GHMP_kinases_N PF00288.26 CDI85190.1 - 0.91 9.8 7.1 11 6.3 1.5 3.3 2 0 0 2 2 2 0 GHMP kinases N terminal domain PAT1 PF09770.9 CDI85190.1 - 1.7 6.8 53.7 3.1 5.9 53.7 1.5 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GAGA_bind PF06217.12 CDI85190.1 - 8.8 6.5 29.2 27 4.9 29.2 1.9 1 0 0 1 1 1 0 GAGA binding protein-like family IF3_C PF00707.22 CDI85191.1 - 4.2e-13 49.1 0.3 2e-12 46.9 0.0 1.9 2 0 0 2 2 2 1 Translation initiation factor IF-3, C-terminal domain TMEM51 PF15345.6 CDI85191.1 - 0.07 13.0 6.8 0.11 12.3 6.8 1.5 1 0 0 1 1 1 0 Transmembrane protein 51 TFIIA PF03153.13 CDI85191.1 - 0.52 10.3 27.2 0.59 10.1 27.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EIF4E-T PF10477.9 CDI85191.1 - 0.7 8.6 15.6 0.75 8.5 15.6 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Suf PF05843.14 CDI85191.1 - 2.6 8.0 13.4 3.1 7.7 13.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2477 PF10631.9 CDI85191.1 - 5.9 7.6 10.6 9.2 6.9 10.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2477) Herpes_TAF50 PF03326.13 CDI85191.1 - 7.6 5.1 21.5 8.2 5.0 21.5 1.1 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) SR-25 PF10500.9 CDI85192.1 - 3.2e-05 23.7 0.9 3.2e-05 23.7 0.9 4.1 4 1 2 6 6 6 1 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI85192.1 - 0.00021 21.0 7.9 0.00021 21.0 7.9 1.8 2 0 0 2 2 2 1 Spt20 family RskA PF10099.9 CDI85192.1 - 0.0084 16.4 2.9 0.0084 16.4 2.9 4.3 2 1 1 3 3 3 1 Anti-sigma-K factor rskA Lin-8 PF03353.15 CDI85192.1 - 1.4 8.4 8.0 1.2 8.6 4.5 2.3 2 1 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF4834 PF16118.5 CDI85192.1 - 2 9.4 6.2 3.4 8.7 1.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Apt1 PF10351.9 CDI85192.1 - 2.4 6.9 13.5 0.28 10.0 5.4 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain RAP1 PF07218.11 CDI85193.1 - 0.0049 15.2 13.4 0.0059 15.0 13.4 1.0 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) DUF572 PF04502.13 CDI85193.1 - 0.025 14.2 28.4 0.029 14.0 28.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SprA-related PF12118.8 CDI85193.1 - 0.033 13.3 40.9 0.038 13.1 40.9 1.1 1 0 0 1 1 1 0 SprA-related family SDA1 PF05285.12 CDI85193.1 - 0.034 13.6 23.6 0.042 13.3 23.6 1.0 1 0 0 1 1 1 0 SDA1 Caldesmon PF02029.15 CDI85193.1 - 0.55 8.9 32.9 0.77 8.5 32.9 1.1 1 0 0 1 1 1 0 Caldesmon AF-4 PF05110.13 CDI85193.1 - 0.65 8.0 42.3 0.97 7.4 42.3 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CCDC106 PF15794.5 CDI85193.1 - 1.7 8.3 36.5 1.8 8.2 22.1 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 RNA_pol_Rpc4 PF05132.14 CDI85193.1 - 2.1 8.7 24.8 2.7 8.4 7.4 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF4484 PF14831.6 CDI85193.1 - 3.3 7.7 23.8 4.5 7.3 23.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) AAA_23 PF13476.6 CDI85193.1 - 3.4 8.1 32.0 4.4 7.8 32.0 1.1 1 0 0 1 1 1 0 AAA domain baeRF_family10 PF18854.1 CDI85193.1 - 3.8 7.8 13.0 5.2 7.3 12.6 1.5 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 Rtf2 PF04641.12 CDI85193.1 - 4.4 6.6 30.3 0.92 8.8 11.8 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger Hid1 PF12722.7 CDI85193.1 - 7.6 4.5 33.7 9.4 4.2 33.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4045 PF13254.6 CDI85194.1 - 4.8 6.7 47.0 5.9 6.4 47.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PNISR PF15996.5 CDI85194.1 - 7.3 6.8 59.0 9.6 6.4 59.0 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR SR-25 PF10500.9 CDI85195.1 - 0.011 15.3 24.0 0.02 14.5 24.0 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein CCSAP PF15748.5 CDI85195.1 - 1.1 9.4 33.7 0.04 14.1 6.7 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Folate_carrier PF01770.18 CDI85195.1 - 1.2 7.8 3.8 2.3 6.8 3.8 1.4 1 0 0 1 1 1 0 Reduced folate carrier DUF5470 PF17564.2 CDI85195.1 - 1.8 8.8 6.1 3 8.1 6.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5470) Med15 PF09606.10 CDI85195.1 - 7 5.2 95.4 8.3 5.0 95.4 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal OmpH PF03938.14 CDI85196.1 - 0.0017 18.7 5.5 0.0018 18.6 5.5 1.1 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) B2-adapt-app_C PF09066.10 CDI85196.1 - 0.0037 17.3 3.7 0.018 15.1 3.7 1.9 1 1 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain Med3 PF11593.8 CDI85196.1 - 0.042 13.0 10.3 0.047 12.9 10.3 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF2722 PF10846.8 CDI85196.1 - 0.052 12.5 4.7 0.043 12.7 4.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) M_domain PF12938.7 CDI85196.1 - 0.11 12.2 15.6 0.13 12.1 15.6 1.1 1 0 0 1 1 1 0 M domain of GW182 Spt20 PF12090.8 CDI85196.1 - 0.26 10.9 11.1 0.26 10.9 11.1 1.1 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 CDI85196.1 - 0.34 10.0 5.3 0.37 9.8 5.3 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Androgen_recep PF02166.16 CDI85196.1 - 1.5 7.6 9.5 1.5 7.6 9.5 1.1 1 0 0 1 1 1 0 Androgen receptor Tim54 PF11711.8 CDI85197.1 - 0.00016 20.6 10.2 0.00021 20.2 10.2 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 CobT PF06213.12 CDI85197.1 - 0.00031 20.2 15.6 0.00031 20.2 15.6 1.9 2 0 0 2 2 2 1 Cobalamin biosynthesis protein CobT RNA_pol_L PF01193.24 CDI85197.1 - 0.00047 19.5 0.0 0.00086 18.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain TctA PF01970.16 CDI85197.1 - 0.062 12.0 4.0 0.44 9.2 4.0 2.0 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family DUF4045 PF13254.6 CDI85197.1 - 0.087 12.5 18.9 0.11 12.1 18.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SAPS PF04499.15 CDI85197.1 - 0.11 11.3 13.1 0.13 11.0 13.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein FAM176 PF14851.6 CDI85197.1 - 0.11 12.1 8.6 0.018 14.7 4.5 1.8 2 0 0 2 2 2 0 FAM176 family DUF3464 PF11947.8 CDI85197.1 - 0.12 12.1 15.7 0.15 11.8 12.2 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 ALMT PF11744.8 CDI85197.1 - 0.13 11.1 15.9 0.17 10.7 15.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM76 PF16046.5 CDI85197.1 - 0.24 10.7 22.4 0.37 10.1 18.8 2.0 2 0 0 2 2 2 0 FAM76 protein CSRNP_N PF16019.5 CDI85197.1 - 0.28 11.1 16.7 0.33 10.8 12.6 2.2 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus PTPRCAP PF15713.5 CDI85197.1 - 0.38 11.0 24.3 0.032 14.5 18.1 1.9 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated SID-1_RNA_chan PF13965.6 CDI85197.1 - 0.4 9.0 7.6 0.49 8.8 7.6 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2052 PF09747.9 CDI85197.1 - 0.47 10.5 20.0 0.12 12.4 15.7 1.8 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Paf1 PF03985.13 CDI85197.1 - 0.56 9.2 20.8 0.11 11.5 16.0 1.8 2 0 0 2 2 2 0 Paf1 Rrn6 PF10214.9 CDI85197.1 - 0.59 8.5 25.3 0.75 8.2 25.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF572 PF04502.13 CDI85197.1 - 0.63 9.6 19.2 0.87 9.1 19.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Serinc PF03348.15 CDI85197.1 - 0.98 8.3 8.8 1.2 8.0 8.8 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) LIM_bind PF01803.16 CDI85197.1 - 1.4 8.4 23.5 1.9 7.9 18.2 2.1 2 0 0 2 2 2 0 LIM-domain binding protein DUF2877 PF11392.8 CDI85197.1 - 1.5 9.5 12.1 10 6.8 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2877) DUF2076 PF09849.9 CDI85197.1 - 1.6 8.7 44.4 0.2 11.6 32.5 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Mcm10 PF09332.11 CDI85197.1 - 1.7 8.0 27.3 0.22 10.9 20.9 1.9 2 0 0 2 2 2 0 Mcm10 replication factor Sporozoite_P67 PF05642.11 CDI85197.1 - 1.9 6.5 9.3 2.2 6.3 9.3 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Connexin PF00029.19 CDI85197.1 - 1.9 8.2 16.3 0.84 9.4 13.0 1.8 2 0 0 2 2 2 0 Connexin Draxin PF15550.6 CDI85197.1 - 2.3 8.0 18.1 2.9 7.7 18.1 1.1 1 0 0 1 1 1 0 Draxin NST1 PF13945.6 CDI85197.1 - 2.4 8.2 35.1 0.28 11.3 26.0 2.0 2 0 0 2 2 2 0 Salt tolerance down-regulator Eapp_C PF10238.9 CDI85197.1 - 2.6 8.1 21.8 2.3 8.3 17.1 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF4366 PF14283.6 CDI85197.1 - 2.6 8.1 11.9 0.44 10.6 8.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) FAM91_C PF14648.6 CDI85197.1 - 2.7 6.7 13.3 3.6 6.3 13.3 1.1 1 0 0 1 1 1 0 FAM91 C-terminus GREB1 PF15782.5 CDI85197.1 - 2.8 5.0 23.8 3.3 4.7 23.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOBP PF15279.6 CDI85197.1 - 3 8.4 22.8 1.7 9.1 18.9 1.9 2 0 0 2 2 2 0 Sine oculis-binding protein EFTUD2 PF16004.5 CDI85197.1 - 3.1 8.4 20.8 4.5 7.9 17.6 2.2 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus HCO3_cotransp PF00955.21 CDI85197.1 - 3.6 6.3 6.8 5.5 5.7 6.8 1.3 1 0 0 1 1 1 0 HCO3- transporter family Gti1_Pac2 PF09729.9 CDI85197.1 - 3.7 7.6 20.7 8.3 6.5 17.7 2.0 2 0 0 2 2 2 0 Gti1/Pac2 family Lin-8 PF03353.15 CDI85197.1 - 3.7 7.0 30.7 2.7 7.4 25.9 2.0 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Kei1 PF08552.11 CDI85197.1 - 4 7.3 17.9 2.7 7.8 14.8 2.0 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 DUF3112 PF11309.8 CDI85197.1 - 4.3 6.7 9.6 1.1 8.7 4.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) Cellulose_synt PF03552.14 CDI85197.1 - 4.4 5.7 5.5 6 5.2 5.5 1.2 1 0 0 1 1 1 0 Cellulose synthase LMBR1 PF04791.16 CDI85197.1 - 4.6 6.0 13.9 5.2 5.9 13.9 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein BPL_N PF09825.9 CDI85197.1 - 5.1 6.1 13.7 6.4 5.7 13.7 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal NACHT_N PF17100.5 CDI85197.1 - 5.6 6.8 24.4 4.1 7.2 18.3 2.0 2 0 0 2 2 2 0 N-terminal domain of NWD NACHT-NTPase DAG_kinase_N PF14513.6 CDI85197.1 - 7.3 6.8 22.9 6 7.1 19.0 2.0 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Pex14_N PF04695.13 CDI85197.1 - 8.6 7.0 46.6 0.15 12.7 33.6 2.1 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region eIF-5_eIF-2B PF01873.17 CDI85198.1 - 5.8e-22 77.8 0.0 7.1e-22 77.5 0.0 1.0 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Metallophos_2 PF12850.7 CDI85199.1 - 3.5e-18 66.3 0.0 4.4e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 CDI85199.1 - 0.0019 18.7 1.0 0.035 14.6 1.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase CHCH PF06747.13 CDI85200.1 - 1.3e-05 25.2 2.7 2.6e-05 24.2 2.7 1.5 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.9 CDI85200.1 - 0.16 12.3 4.1 0.23 11.8 4.1 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Pex14_N PF04695.13 CDI85201.1 - 1.4 9.5 7.3 2.5 8.8 7.3 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ribosomal_L7Ae PF01248.26 CDI85202.1 - 3.6e-23 81.1 1.4 6.8e-23 80.2 1.4 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 CDI85202.1 - 0.043 13.9 0.0 0.08 13.0 0.0 1.4 1 0 0 1 1 1 0 RNase P subunit Pop3 DUF1645 PF07816.11 CDI85203.1 - 6.2e-06 26.9 26.0 0.0025 18.4 5.9 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1645) Plasmodium_Vir PF05795.11 CDI85203.1 - 0.0017 17.9 20.6 0.019 14.4 5.6 2.1 2 0 0 2 2 2 2 Plasmodium vivax Vir protein RskA PF10099.9 CDI85203.1 - 0.0081 16.5 11.9 0.0081 16.5 11.9 3.0 1 1 0 2 2 2 1 Anti-sigma-K factor rskA Lin-8 PF03353.15 CDI85203.1 - 0.013 15.0 33.2 0.057 13.0 12.9 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF3506 PF12014.8 CDI85203.1 - 0.052 13.6 6.8 0.092 12.8 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3506) PNISR PF15996.5 CDI85203.1 - 0.18 12.0 35.1 0.16 12.2 10.2 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Nha1_C PF08619.10 CDI85203.1 - 1.9 7.6 34.0 3.9 6.6 34.0 1.5 1 1 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus SR-25 PF10500.9 CDI85203.1 - 3 7.4 52.1 0.2 11.2 19.7 2.6 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF3446 PF11928.8 CDI85203.1 - 7.5 6.9 33.7 11 6.4 8.3 2.8 2 0 0 2 2 2 0 Early growth response N-terminal domain Chorion_2 PF03964.15 CDI85204.1 - 0.14 13.1 0.5 0.14 13.1 0.5 4.2 3 1 0 3 3 3 0 Chorion family 2 TFIIA PF03153.13 CDI85204.1 - 0.34 10.8 100.0 1.5 8.7 47.3 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CDI85205.1 - 0.0015 18.2 11.2 0.0016 18.1 11.2 1.2 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist DUF4471 PF14740.6 CDI85205.1 - 0.0048 16.2 6.1 0.0049 16.1 6.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4471) SpoIIP PF07454.11 CDI85205.1 - 0.0058 16.1 10.1 0.0076 15.7 10.1 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) MMR1 PF08505.10 CDI85205.1 - 0.012 16.0 12.9 0.017 15.4 12.9 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF908 PF06012.12 CDI85205.1 - 0.026 14.0 6.8 0.04 13.3 6.8 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SLC12 PF03522.15 CDI85205.1 - 0.035 13.1 7.3 0.036 13.1 7.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI85205.1 - 0.038 12.1 7.6 0.035 12.3 7.6 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2464 PF10240.9 CDI85205.1 - 0.051 13.2 5.1 0.068 12.7 5.1 1.2 1 0 0 1 1 1 0 Multivesicular body subunit 12 MDM10 PF12519.8 CDI85205.1 - 0.066 12.1 6.4 0.07 12.0 6.4 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF2126 PF09899.9 CDI85205.1 - 0.093 10.8 7.4 0.094 10.8 7.4 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CAF1 PF04857.20 CDI85205.1 - 0.1 11.8 4.4 0.095 11.8 4.4 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease NPR3 PF03666.13 CDI85205.1 - 0.11 11.3 8.7 0.13 11.0 8.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_S64 PF08192.11 CDI85205.1 - 0.11 10.9 7.9 0.11 10.9 7.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 TERB2 PF15101.6 CDI85205.1 - 0.14 12.2 15.2 0.24 11.5 15.2 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 OATP PF03137.20 CDI85205.1 - 0.16 10.2 3.7 0.21 9.8 3.7 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CLN3 PF02487.17 CDI85205.1 - 0.16 10.9 7.7 0.25 10.3 7.7 1.3 1 0 0 1 1 1 0 CLN3 protein DUF2828 PF11443.8 CDI85205.1 - 0.18 9.9 11.0 0.2 9.7 11.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Plasmodium_Vir PF05795.11 CDI85205.1 - 0.28 10.6 3.5 0.29 10.5 3.5 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein ALMT PF11744.8 CDI85205.1 - 0.31 9.8 9.5 0.41 9.4 9.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4638 PF15472.6 CDI85205.1 - 0.43 10.3 6.7 0.48 10.1 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) GREB1 PF15782.5 CDI85205.1 - 0.51 7.4 11.1 0.48 7.5 11.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Sec62 PF03839.16 CDI85205.1 - 0.58 9.6 6.5 0.84 9.1 6.5 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 SID-1_RNA_chan PF13965.6 CDI85205.1 - 0.59 8.5 6.2 0.82 8.0 6.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 CDI85205.1 - 0.72 8.7 4.3 0.92 8.4 4.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Tim54 PF11711.8 CDI85205.1 - 1 8.1 13.4 1.7 7.4 13.4 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ferlin_C PF16165.5 CDI85205.1 - 1 9.3 4.2 1.9 8.4 3.9 1.5 1 1 0 1 1 1 0 Ferlin C-terminus DUF2098 PF09871.9 CDI85205.1 - 1.1 9.6 5.9 2.3 8.6 5.9 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) Membralin PF09746.9 CDI85205.1 - 1.2 8.1 6.5 1.4 7.9 6.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein DDRGK PF09756.9 CDI85205.1 - 1.2 8.7 20.0 1.9 8.1 20.0 1.3 1 0 0 1 1 1 0 DDRGK domain PIP5K PF01504.18 CDI85205.1 - 1.3 8.2 10.2 1.9 7.7 10.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase PRC2_HTH_1 PF18118.1 CDI85205.1 - 1.4 9.8 11.5 0.81 10.5 9.4 1.7 2 0 0 2 2 1 0 Polycomb repressive complex 2 tri-helical domain Paf1 PF03985.13 CDI85205.1 - 1.5 7.7 17.6 2.2 7.2 17.6 1.2 1 0 0 1 1 1 0 Paf1 Cellulose_synt PF03552.14 CDI85205.1 - 1.8 7.0 4.0 2.1 6.7 4.0 1.1 1 0 0 1 1 1 0 Cellulose synthase eIF-3_zeta PF05091.12 CDI85205.1 - 1.9 7.4 17.1 2.6 6.9 17.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) V_ATPase_I PF01496.19 CDI85205.1 - 2.4 5.9 14.7 3.4 5.5 14.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Coilin_N PF15862.5 CDI85205.1 - 2.6 7.8 13.6 5.9 6.7 13.6 1.6 1 0 0 1 1 1 0 Coilin N-terminus Connexin PF00029.19 CDI85205.1 - 2.8 7.6 14.0 3.7 7.2 13.8 1.4 1 1 0 1 1 1 0 Connexin HCO3_cotransp PF00955.21 CDI85205.1 - 3.7 6.3 4.6 4.6 5.9 4.6 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF913 PF06025.12 CDI85205.1 - 3.9 6.4 14.0 2.9 6.8 12.9 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) Baculo_PP31 PF05311.11 CDI85205.1 - 4.2 6.8 11.9 7 6.0 11.9 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) NEMP PF10225.9 CDI85205.1 - 4.2 7.0 5.2 6.6 6.3 5.2 1.4 1 0 0 1 1 1 0 NEMP family DUF3408 PF11888.8 CDI85205.1 - 4.4 7.5 17.3 10 6.3 17.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) BBL5 PF07289.11 CDI85205.1 - 6.7 5.6 8.3 8.8 5.3 8.3 1.2 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein DUF719 PF05334.13 CDI85205.1 - 7.1 6.8 13.9 0.67 10.1 8.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF719) RR_TM4-6 PF06459.12 CDI85206.1 - 0.025 14.4 22.6 0.03 14.2 22.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF3_subunit PF08597.10 CDI85206.1 - 0.065 13.1 26.2 0.089 12.7 26.2 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Presenilin PF01080.17 CDI85206.1 - 0.1 11.4 29.4 0.11 11.2 29.4 1.1 1 0 0 1 1 1 0 Presenilin MRP-S31 PF15433.6 CDI85206.1 - 0.12 12.1 22.8 0.13 11.9 22.8 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 SMYLE_N PF18615.1 CDI85206.1 - 0.13 11.8 16.8 0.14 11.7 16.8 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain eIF-3_zeta PF05091.12 CDI85206.1 - 0.26 10.2 31.5 0.3 10.0 31.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) LicD PF04991.13 CDI85206.1 - 0.42 10.7 5.6 0.5 10.5 5.6 1.1 1 0 0 1 1 1 0 LicD family FAM60A PF15396.6 CDI85206.1 - 0.44 10.5 16.2 0.55 10.2 16.2 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Smg8_Smg9 PF10220.9 CDI85206.1 - 0.51 8.6 23.7 0.56 8.5 23.7 1.0 1 0 0 1 1 1 0 Smg8_Smg9 PAT1 PF09770.9 CDI85206.1 - 0.72 8.1 38.8 0.8 7.9 38.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SAGA-Tad1 PF12767.7 CDI85206.1 - 0.75 9.5 21.5 0.88 9.3 21.5 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit RIFIN PF02009.16 CDI85206.1 - 0.76 9.6 19.7 0.97 9.3 19.7 1.0 1 0 0 1 1 1 0 Rifin GAGA_bind PF06217.12 CDI85206.1 - 0.95 9.7 19.7 1.1 9.5 19.7 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family CCSAP PF15748.5 CDI85206.1 - 0.97 9.6 27.8 1.2 9.2 27.8 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated V_ATPase_I PF01496.19 CDI85206.1 - 1.3 6.9 21.8 1.5 6.7 21.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1387 PF07139.11 CDI85206.1 - 1.4 8.6 22.8 1.7 8.3 22.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) CDC45 PF02724.14 CDI85206.1 - 1.5 7.0 23.6 1.7 6.8 23.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 CDI85206.1 - 1.7 8.7 18.8 2 8.4 18.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4551 PF15087.6 CDI85206.1 - 1.8 7.3 19.5 2 7.2 19.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SLC12 PF03522.15 CDI85206.1 - 2 7.4 25.5 2.2 7.2 25.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SID-1_RNA_chan PF13965.6 CDI85206.1 - 2.1 6.6 8.9 2.4 6.5 8.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF572 PF04502.13 CDI85206.1 - 2.2 7.8 22.2 2.6 7.6 22.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Nop53 PF07767.11 CDI85206.1 - 2.4 7.5 33.0 3 7.2 33.0 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF908 PF06012.12 CDI85206.1 - 3.3 7.0 19.8 4.3 6.7 19.8 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Zip PF02535.22 CDI85206.1 - 3.7 6.7 15.7 4 6.6 15.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter AUX_IAA PF02309.16 CDI85206.1 - 4.3 7.1 16.7 5.1 6.9 16.7 1.3 1 0 0 1 1 1 0 AUX/IAA family CSG2 PF16965.5 CDI85206.1 - 4.3 6.2 13.2 5.9 5.7 13.2 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator PPP4R2 PF09184.11 CDI85206.1 - 5.3 6.5 16.1 6.4 6.3 16.1 1.1 1 0 0 1 1 1 0 PPP4R2 PA26 PF04636.13 CDI85206.1 - 7 5.5 17.2 7.6 5.3 17.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) XRN_M PF17846.1 CDI85206.1 - 7.3 5.4 17.5 8 5.3 17.5 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Lin-8 PF03353.15 CDI85206.1 - 7.8 6.0 32.0 9.2 5.7 32.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Hid1 PF12722.7 CDI85206.1 - 8.7 4.3 26.0 9.4 4.2 26.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ank_5 PF13857.6 CDI85207.1 - 4.3e-07 30.1 0.0 8.2e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDI85207.1 - 0.00035 21.1 0.0 0.00076 20.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 CDI85207.1 - 0.0047 17.3 0.3 0.012 16.0 0.3 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.7 CDI85207.1 - 0.0092 16.6 0.1 0.03 14.9 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDI85207.1 - 0.029 14.9 0.1 0.083 13.5 0.1 1.8 1 0 0 1 1 1 0 Ankyrin repeat Mitofilin PF09731.9 CDI85208.1 - 5 5.8 55.1 2.1 7.1 35.8 2.2 2 0 0 2 2 2 0 Mitochondrial inner membrane protein RskA PF10099.9 CDI85209.1 - 0.0023 18.3 23.5 0.0025 18.1 23.5 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF4342 PF14242.6 CDI85209.1 - 0.11 12.4 1.9 0.18 11.8 1.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) DUF4179 PF13786.6 CDI85209.1 - 0.13 12.8 2.2 0.17 12.4 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) TFIIA PF03153.13 CDI85209.1 - 0.21 11.6 34.6 0.22 11.5 34.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3881 PF12997.7 CDI85209.1 - 1.9 7.6 9.8 14 4.8 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3881) PA26 PF04636.13 CDI85209.1 - 2.5 6.9 10.6 2.7 6.8 10.6 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF2232 PF09991.9 CDI85209.1 - 2.7 7.1 5.5 3 7.0 5.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Pex14_N PF04695.13 CDI85209.1 - 4.5 7.9 25.2 5.8 7.6 25.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PAT1 PF09770.9 CDI85209.1 - 4.6 5.4 21.9 4.8 5.3 21.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EOS1 PF12326.8 CDI85209.1 - 4.7 7.1 5.1 5.4 6.9 5.1 1.2 1 0 0 1 1 1 0 N-glycosylation protein XRN_M PF17846.1 CDI85209.1 - 5.1 5.9 11.8 5.5 5.8 11.8 1.0 1 0 0 1 1 1 0 Xrn1 helical domain R_equi_Vir PF05526.11 CDI85209.1 - 7.1 6.5 12.9 8 6.3 12.9 1.2 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Bul1_N PF04425.12 CDI85209.1 - 7.6 5.2 14.6 9 4.9 14.6 1.0 1 0 0 1 1 1 0 Bul1 N terminus UPF0560 PF10577.9 CDI85209.1 - 7.7 4.9 16.8 7.3 4.9 16.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 BAF1_ABF1 PF04684.13 CDI85209.1 - 8.1 5.4 17.2 9 5.2 17.2 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor TetR_C_32 PF09209.11 CDI85211.1 - 0.017 15.1 0.6 0.064 13.2 0.6 1.9 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain SPX PF03105.19 CDI85211.1 - 0.02 14.8 1.3 0.02 14.8 1.3 2.9 2 1 0 2 2 2 0 SPX domain DUF1645 PF07816.11 CDI85211.1 - 0.12 13.0 18.9 1.9 9.0 9.8 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1645) DUF3446 PF11928.8 CDI85211.1 - 0.69 10.3 30.9 1.2 9.5 2.3 3.2 3 0 0 3 3 3 0 Early growth response N-terminal domain DUF4692 PF15763.5 CDI85211.1 - 4.2 7.8 14.0 1.5 9.3 0.2 2.8 3 0 0 3 3 3 0 Regulator of human erythroid cell expansion (RHEX) Ipi1_N PF12333.8 CDI85211.1 - 4.5 7.9 13.9 5.8 7.6 0.1 4.1 3 1 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation DUF2877 PF11392.8 CDI85211.1 - 4.9 7.9 10.1 0.14 12.9 0.6 3.1 3 2 1 4 4 4 0 Protein of unknown function (DUF2877) Collectrin PF16959.5 CDI85212.1 - 0.18 11.6 0.1 0.18 11.6 0.1 2.3 2 1 1 3 3 3 0 Renal amino acid transporter Vac7 PF12751.7 CDI85212.1 - 1.9 7.8 23.5 2.1 7.7 23.5 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 DUF4045 PF13254.6 CDI85212.1 - 7.6 6.1 37.2 8.7 5.9 37.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Presenilin PF01080.17 CDI85213.1 - 0.91 8.2 44.1 1 8.0 44.1 1.0 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI85213.1 - 4.5 6.2 39.0 5.2 6.0 39.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF2828 PF11443.8 CDI85213.1 - 5.6 4.9 31.2 7 4.6 31.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) XRN_M PF17846.1 CDI85213.1 - 6.3 5.6 30.7 6.6 5.6 30.7 1.0 1 0 0 1 1 1 0 Xrn1 helical domain PA26 PF04636.13 CDI85213.1 - 6.3 5.6 29.3 7 5.5 29.3 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF3295 PF11702.8 CDI85213.1 - 8.7 5.6 31.7 11 5.2 31.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) SRP-alpha_N PF04086.13 CDI85213.1 - 9.1 6.1 32.5 11 5.8 32.5 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal OATP PF03137.20 CDI85214.1 - 0.03 12.6 1.5 0.056 11.7 1.5 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family V_ATPase_I PF01496.19 CDI85214.1 - 0.087 10.7 12.7 0.14 10.1 12.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI85214.1 - 0.72 8.8 6.4 1.4 7.9 6.4 1.4 1 0 0 1 1 1 0 CLN3 protein UTP25 PF06862.12 CDI85214.1 - 1.2 7.8 5.8 1.7 7.3 5.8 1.1 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 MAJIN PF15077.6 CDI85214.1 - 7 6.4 8.4 17 5.1 8.4 1.6 1 0 0 1 1 1 0 Membrane-anchored junction protein SR-25 PF10500.9 CDI85216.1 - 0.0016 18.1 15.6 0.0016 18.1 15.6 2.0 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein Cwf_Cwc_15 PF04889.12 CDI85216.1 - 0.095 12.4 11.4 0.11 12.2 11.4 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ABC2_membrane_3 PF12698.7 CDI85216.1 - 1.5 7.9 7.2 1.7 7.7 7.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF572 PF04502.13 CDI85216.1 - 1.5 8.3 14.0 1.8 8.1 14.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) GET2 PF08690.10 CDI85217.1 - 0.14 11.8 6.1 0.22 11.2 6.1 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 XRN_M PF17846.1 CDI85218.1 - 0.031 13.3 17.0 0.034 13.1 17.0 1.2 1 0 0 1 1 1 0 Xrn1 helical domain PAT1 PF09770.9 CDI85218.1 - 0.15 10.4 36.2 0.16 10.2 36.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SOBP PF15279.6 CDI85218.1 - 0.19 12.3 27.6 0.21 12.1 27.6 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein CAC1F_C PF16885.5 CDI85218.1 - 0.28 10.8 19.1 0.34 10.5 19.1 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term SR-25 PF10500.9 CDI85218.1 - 0.85 9.2 38.0 1.8 8.1 27.5 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein CCSAP PF15748.5 CDI85218.1 - 1.5 9.0 33.8 2.1 8.5 33.8 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF966 PF06136.13 CDI85218.1 - 2.9 7.5 26.0 3.7 7.2 26.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) LAP1C PF05609.12 CDI85218.1 - 3.1 6.8 28.6 3.9 6.4 28.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF4569 PF15133.6 CDI85218.1 - 4.1 7.1 34.5 0.27 10.9 27.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4569) O-antigen_lig PF13425.6 CDI85218.1 - 4.5 6.0 12.2 5.7 5.6 12.2 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Asp-B-Hydro_N PF05279.11 CDI85218.1 - 4.5 7.3 21.8 6.7 6.7 21.8 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SWI-SNF_Ssr4 PF08549.10 CDI85218.1 - 6.1 5.3 26.9 7.4 5.1 26.9 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Borrelia_P83 PF05262.11 CDI85218.1 - 9.5 4.6 25.8 12 4.3 25.8 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Phage_AlpA PF05930.12 CDI85219.1 - 0.033 14.0 0.0 2.2 8.2 0.0 2.3 2 0 0 2 2 2 0 Prophage CP4-57 regulatory protein (AlpA) UBA_2 PF08587.11 CDI85219.1 - 0.049 13.7 0.0 0.098 12.8 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) Calreticulin PF00262.18 CDI85220.1 - 4.9e-16 58.5 0.0 1.6e-13 50.2 0.0 2.9 1 1 1 2 2 2 2 Calreticulin family Cullin PF00888.22 CDI85221.1 - 2.1e-15 56.4 0.0 4.5e-12 45.4 0.0 2.1 2 0 0 2 2 2 2 Cullin family Cullin_Nedd8 PF10557.9 CDI85221.1 - 7.2e-09 35.6 1.2 1.5e-08 34.5 0.2 2.1 2 1 0 2 2 2 1 Cullin protein neddylation domain AAA_6 PF12774.7 CDI85223.1 - 4.7e-141 469.5 6.3 2e-130 434.6 0.1 4.2 4 0 0 4 4 4 2 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDI85223.1 - 1e-119 400.2 3.4 1e-119 400.2 3.4 4.4 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 CDI85223.1 - 7.2e-73 244.0 0.0 3.6e-67 225.4 0.0 3.6 3 0 0 3 3 3 3 P-loop containing dynein motor region AAA_8 PF12780.7 CDI85223.1 - 1.6e-54 185.0 0.7 9.1e-47 159.6 0.0 4.7 2 1 2 4 4 4 2 P-loop containing dynein motor region D4 Dynein_C PF18199.1 CDI85223.1 - 5.9e-53 180.1 6.5 1.8e-46 158.8 0.0 4.1 3 1 1 4 4 3 2 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 CDI85223.1 - 9.5e-53 178.4 0.1 9.5e-53 178.4 0.1 2.8 3 0 0 3 3 2 1 Dynein heavy chain AAA lid domain AAA_9 PF12781.7 CDI85223.1 - 1.3e-49 168.3 11.7 7.9e-32 110.2 0.2 4.1 3 1 1 4 4 4 2 ATP-binding dynein motor region MT PF12777.7 CDI85223.1 - 5.7e-47 160.4 12.5 1.4e-45 155.8 7.1 2.3 2 0 0 2 2 2 2 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 CDI85223.1 - 1.2e-23 83.6 0.0 4.2e-23 81.8 0.0 2.1 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 CDI85223.1 - 2.2e-22 79.6 0.0 2.8e-05 24.1 0.0 6.6 6 1 0 6 6 4 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 CDI85223.1 - 2.5e-22 78.9 0.7 9.7e-22 77.1 0.1 2.4 2 0 0 2 2 1 1 AAA+ lid domain Dynein_heavy PF03028.15 CDI85223.1 - 7e-17 61.6 0.9 2.1e-09 37.5 0.1 4.7 3 1 1 4 4 4 2 Dynein heavy chain region D6 P-loop domain AAA PF00004.29 CDI85223.1 - 2.9e-09 37.4 0.3 0.028 14.9 0.0 5.5 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDI85223.1 - 5.9e-07 29.8 0.7 3.1 8.1 0.0 5.2 5 0 0 5 5 4 2 AAA domain AAA_16 PF13191.6 CDI85223.1 - 5.7e-06 26.8 2.9 0.69 10.3 0.0 6.1 5 1 0 5 5 4 1 AAA ATPase domain Phage_GP20 PF06810.11 CDI85223.1 - 0.00054 19.8 11.9 0.00054 19.8 11.9 3.9 4 1 0 4 4 3 1 Phage minor structural protein GP20 AAA_18 PF13238.6 CDI85223.1 - 0.00063 20.3 0.0 0.22 12.1 0.0 4.1 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 CDI85223.1 - 0.00082 18.5 1.1 0.31 10.1 0.0 3.4 3 0 0 3 3 3 1 Type II/IV secretion system protein RNA_helicase PF00910.22 CDI85223.1 - 0.0014 19.0 0.0 0.62 10.5 0.0 3.6 3 0 0 3 3 3 1 RNA helicase Mg_chelatase PF01078.21 CDI85223.1 - 0.0022 17.4 0.5 3.6 6.9 0.0 3.8 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI DEAD PF00270.29 CDI85223.1 - 0.0068 16.2 0.1 2.9 7.6 0.0 3.8 3 1 0 3 3 2 1 DEAD/DEAH box helicase AAA_25 PF13481.6 CDI85223.1 - 0.044 13.4 2.2 12 5.4 0.2 3.7 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 CDI85223.1 - 0.065 13.2 2.6 5.9 6.9 0.3 3.4 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 CDI85223.1 - 0.35 10.6 8.9 2.3 7.9 0.1 4.1 4 0 0 4 4 3 0 AAA domain DUF853 PF05872.12 CDI85223.1 - 0.74 8.3 13.8 0.6 8.6 0.0 3.7 4 0 0 4 4 3 0 Bacterial protein of unknown function (DUF853) SRP54 PF00448.22 CDI85223.1 - 0.99 9.0 7.2 14 5.2 0.1 4.3 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain DUF3138 PF11336.8 CDI85223.1 - 2.2 6.8 5.3 3.7 6.0 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Spc7 PF08317.11 CDI85223.1 - 3.2 6.5 45.5 0.078 11.9 6.8 4.0 4 0 0 4 4 4 0 Spc7 kinetochore protein CBP_BcsO PF17037.5 CDI85224.1 - 0.86 9.7 4.1 2.7 8.1 3.5 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsO Shadoo PF14999.6 CDI85225.1 - 0.011 15.8 11.1 0.11 12.6 5.2 2.6 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective DUF755 PF05501.11 CDI85225.1 - 0.025 14.9 6.3 0.025 14.9 6.3 4.2 5 0 0 5 5 5 0 Domain of unknown function (DUF755) SR-25 PF10500.9 CDI85225.1 - 0.21 11.2 13.0 0.15 11.7 6.4 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein LSM14 PF12701.7 CDI85226.1 - 3.6e-24 84.6 0.0 6.4e-24 83.9 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 CDI85226.1 - 7.3e-06 26.0 0.0 1.3e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain FDF PF09532.10 CDI85226.1 - 6.6e-05 23.7 11.8 0.017 16.0 2.9 2.4 1 1 1 2 2 2 2 FDF domain Spt20 PF12090.8 CDI85226.1 - 0.65 9.6 10.3 1 8.9 10.3 1.2 1 0 0 1 1 1 0 Spt20 family Hexokinase_1 PF00349.21 CDI85229.1 - 0.0084 16.0 1.3 0.013 15.4 1.3 1.3 1 0 0 1 1 1 1 Hexokinase DUF3126 PF11324.8 CDI85229.1 - 0.042 13.7 0.1 0.042 13.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3126) RusA PF05866.11 CDI85229.1 - 0.085 13.4 3.1 0.12 12.9 3.1 1.3 1 0 0 1 1 1 0 Endodeoxyribonuclease RusA PIG-S PF10510.9 CDI85229.1 - 0.21 10.4 10.2 0.22 10.3 10.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein DUF2267 PF10025.9 CDI85229.1 - 0.23 11.7 9.7 0.33 11.2 9.7 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) MMR1 PF08505.10 CDI85229.1 - 0.62 10.3 12.3 0.6 10.3 12.3 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Mcm10 PF09332.11 CDI85229.1 - 0.68 9.3 14.4 0.74 9.2 14.4 1.1 1 0 0 1 1 1 0 Mcm10 replication factor Band_3_cyto PF07565.13 CDI85229.1 - 0.68 9.7 6.8 0.68 9.7 6.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Tim54 PF11711.8 CDI85229.1 - 0.71 8.6 7.5 0.73 8.6 7.5 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF3418 PF11898.8 CDI85229.1 - 1.1 7.8 14.9 1.5 7.4 14.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3418) Sporozoite_P67 PF05642.11 CDI85229.1 - 1.1 7.2 11.0 1.3 7.1 11.0 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Membralin PF09746.9 CDI85229.1 - 1.7 7.6 4.2 1.7 7.6 4.2 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF3533 PF12051.8 CDI85229.1 - 1.8 7.4 7.6 1.8 7.4 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Sec62 PF03839.16 CDI85229.1 - 2 7.8 7.2 2.2 7.7 7.2 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 HI0933_like PF03486.14 CDI85229.1 - 2.3 6.9 9.2 2.8 6.6 9.2 1.1 1 0 0 1 1 1 0 HI0933-like protein ALMT PF11744.8 CDI85229.1 - 2.7 6.7 8.2 2.8 6.7 8.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter BAF1_ABF1 PF04684.13 CDI85229.1 - 2.9 6.9 14.4 3.6 6.5 14.4 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor ABC2_membrane_3 PF12698.7 CDI85229.1 - 3.4 6.7 3.9 3.4 6.7 3.9 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Presenilin PF01080.17 CDI85229.1 - 4.1 6.1 11.3 4 6.1 11.3 1.2 1 0 0 1 1 1 0 Presenilin FAM150 PF15129.6 CDI85229.1 - 4.7 7.4 9.4 7 6.8 9.4 1.2 1 0 0 1 1 1 0 FAM150 family Connexin PF00029.19 CDI85229.1 - 4.8 6.9 6.5 5.3 6.7 6.5 1.2 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 CDI85229.1 - 5.1 4.9 9.1 5.1 4.9 9.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UPF0560 PF10577.9 CDI85229.1 - 7 5.0 16.4 8.3 4.8 16.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 YicC_N PF03755.13 CDI85229.1 - 7.1 7.1 11.2 9.6 6.7 11.2 1.2 1 0 0 1 1 1 0 YicC-like family, N-terminal region TruD PF01142.18 CDI85231.1 - 1.7e-42 145.7 16.2 8.8e-21 74.2 0.0 4.8 5 0 0 5 5 5 4 tRNA pseudouridine synthase D (TruD) Utp14 PF04615.13 CDI85231.1 - 0.0012 17.5 34.4 0.0012 17.5 34.4 6.8 3 3 1 4 4 4 1 Utp14 protein SUIM_assoc PF16619.5 CDI85231.1 - 0.0028 17.7 5.7 0.0028 17.7 5.7 14.9 9 4 2 11 11 11 4 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI85231.1 - 0.004 16.8 19.4 0.004 16.8 19.4 12.2 10 3 1 12 12 12 5 Spt20 family Na_trans_assoc PF06512.13 CDI85231.1 - 0.61 10.3 0.0 0.61 10.3 0.0 7.3 5 4 0 5 5 5 0 Sodium ion transport-associated HEM4 PF02602.15 CDI85232.1 - 8.1e-07 28.6 6.1 8.1e-07 28.6 6.1 2.5 2 1 0 2 2 2 1 Uroporphyrinogen-III synthase HemD EIF4E-T PF10477.9 CDI85232.1 - 0.019 13.8 9.7 0.022 13.6 9.7 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF2052 PF09747.9 CDI85232.1 - 0.19 11.8 9.1 0.3 11.2 9.1 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Hid1 PF12722.7 CDI85232.1 - 0.61 8.1 7.8 0.85 7.7 7.8 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.12 CDI85232.1 - 0.67 9.7 6.1 1 9.1 6.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI85232.1 - 0.77 8.7 5.3 1.1 8.3 5.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 dsDNA_bind PF01984.20 CDI85232.1 - 1.2 9.4 24.0 1.3 9.4 6.7 2.5 2 0 0 2 2 2 0 Double-stranded DNA-binding domain DUF4834 PF16118.5 CDI85232.1 - 2.7 9.0 12.1 12 6.9 1.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF2201 PF09967.9 CDI85233.1 - 0.31 11.2 4.5 0.78 9.9 4.5 1.6 1 0 0 1 1 1 0 VWA-like domain (DUF2201) BUD22 PF09073.10 CDI85234.1 - 0.0026 17.2 4.8 0.0026 17.2 4.8 2.8 1 1 1 2 2 2 1 BUD22 Lin-8 PF03353.15 CDI85234.1 - 0.0059 16.2 2.6 0.0059 16.2 2.6 2.9 1 1 1 2 2 1 1 Ras-mediated vulval-induction antagonist Apt1 PF10351.9 CDI85234.1 - 0.032 13.1 30.2 0.025 13.5 7.1 2.6 1 1 1 2 2 2 0 Golgi-body localisation protein domain DUF1115 PF06544.12 CDI85234.1 - 0.045 13.8 8.9 1.7 8.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1115) Suf PF05843.14 CDI85234.1 - 0.053 13.5 32.9 0.5 10.3 24.1 2.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF4770 PF15994.5 CDI85234.1 - 0.3 11.3 21.2 0.11 12.8 11.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) SPX PF03105.19 CDI85234.1 - 0.35 10.7 38.2 18 5.1 31.5 2.3 1 1 1 2 2 2 0 SPX domain Activator_LAG-3 PF11498.8 CDI85234.1 - 0.47 9.4 66.5 0.45 9.4 45.2 2.3 2 0 0 2 2 2 0 Transcriptional activator LAG-3 TFIIA PF03153.13 CDI85234.1 - 0.53 10.2 76.9 1.4 8.8 55.8 2.1 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 CDI85234.1 - 0.58 11.2 34.7 9.5 7.3 17.2 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) Med15 PF09606.10 CDI85234.1 - 1.3 7.6 56.0 0.15 10.7 34.6 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal eIF-3_zeta PF05091.12 CDI85234.1 - 6.4 5.6 30.7 0.82 8.6 19.9 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PRC2_HTH_1 PF18118.1 CDI85234.1 - 6.6 7.6 21.8 1.5 9.7 9.0 3.7 4 0 0 4 4 4 0 Polycomb repressive complex 2 tri-helical domain Spt20 PF12090.8 CDI85236.1 - 2.2 7.9 29.8 2.7 7.5 29.8 1.2 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI85237.1 - 6.5e-07 30.2 1.9 6.5e-07 30.2 1.9 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF4834) SUIM_assoc PF16619.5 CDI85237.1 - 6.4e-06 26.1 43.5 0.087 12.9 0.0 5.6 3 3 1 4 4 2 1 Unstructured region C-term to UIM in Ataxin3 YfhO PF09586.10 CDI85237.1 - 0.0018 16.6 8.2 0.0018 16.6 8.2 1.4 1 1 0 1 1 1 1 Bacterial membrane protein YfhO TMEM208_SND2 PF05620.11 CDI85237.1 - 0.0023 17.8 1.7 0.0023 17.8 1.7 3.5 3 1 0 4 4 4 1 SRP-independent targeting protein 2/TMEM208 GBV-C_env PF12786.7 CDI85237.1 - 0.0026 16.5 4.9 0.0059 15.4 4.9 1.5 1 0 0 1 1 1 1 GB virus C genotype envelope RskA PF10099.9 CDI85237.1 - 0.0028 18.0 2.6 0.0028 18.0 2.6 5.4 2 1 2 4 4 2 1 Anti-sigma-K factor rskA Tmemb_9 PF05434.11 CDI85237.1 - 0.0044 16.9 5.0 0.0044 16.9 5.0 3.0 3 0 0 3 3 3 1 TMEM9 CBP_BcsG PF11658.8 CDI85237.1 - 0.0056 15.1 6.9 0.0056 15.1 6.9 3.1 3 1 0 3 3 2 1 Cellulose biosynthesis protein BcsG PigN PF04987.14 CDI85237.1 - 0.0072 15.2 2.1 0.0072 15.2 2.1 1.7 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) Pex24p PF06398.11 CDI85237.1 - 0.013 14.5 0.2 0.025 13.6 0.2 1.4 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin CTU2 PF10288.9 CDI85237.1 - 0.043 14.0 0.4 0.043 14.0 0.4 3.5 4 0 0 4 4 4 0 Cytoplasmic tRNA 2-thiolation protein 2 Wzy_C PF04932.15 CDI85237.1 - 0.045 13.4 0.2 0.18 11.5 0.0 2.0 2 1 0 2 2 2 0 O-Antigen ligase TRAP_alpha PF03896.16 CDI85237.1 - 0.089 12.0 4.8 0.11 11.7 1.9 2.3 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.6 CDI85237.1 - 0.12 12.0 9.9 0.085 12.5 2.0 3.3 3 0 0 3 3 3 0 FAM176 family FA_desaturase PF00487.24 CDI85237.1 - 0.33 10.7 0.0 0.33 10.7 0.0 3.0 3 1 1 4 4 4 0 Fatty acid desaturase SP_C-Propep PF08999.10 CDI85237.1 - 0.91 9.3 8.0 0.55 10.0 5.1 2.1 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide SID-1_RNA_chan PF13965.6 CDI85237.1 - 2.8 6.2 13.1 0.14 10.5 5.7 1.9 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 GPI2 PF06432.11 CDI85237.1 - 3.1 7.2 7.0 9 5.6 7.0 1.8 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase Mak16 PF04874.14 CDI85237.1 - 3.9 8.1 22.6 1.3 9.6 4.4 3.5 3 0 0 3 3 3 0 Mak16 protein C-terminal region CSG2 PF16965.5 CDI85237.1 - 6.7 5.5 11.9 0.075 12.0 3.2 2.0 2 1 1 3 3 3 0 Ceramide synthase regulator O-antigen_lig PF13425.6 CDI85237.1 - 9.3 4.9 10.4 0.14 11.0 1.8 1.9 1 1 1 2 2 2 0 O-antigen ligase like membrane protein DNAJ_related PF12339.8 CDI85239.1 - 0.001 19.3 0.1 0.001 19.3 0.1 1.6 2 0 0 2 2 2 1 DNA-J related protein SUIM_assoc PF16619.5 CDI85239.1 - 3.2 7.9 26.8 1.5 8.9 11.4 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI85240.1 - 0.0084 16.1 16.0 0.0097 15.9 16.0 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF4048 PF13257.6 CDI85240.1 - 0.062 13.1 7.8 0.081 12.8 7.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4048) DUF2489 PF10675.9 CDI85240.1 - 1.1 9.2 14.4 3.5 7.6 3.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) Suf PF05843.14 CDI85240.1 - 1.7 8.6 7.2 2.2 8.2 7.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SUIM_assoc PF16619.5 CDI85240.1 - 5.2 7.2 27.0 0.5 10.5 13.9 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 ANAPC_CDC26 PF10471.9 CDI85240.1 - 5.8 7.8 25.5 9 7.2 13.2 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 CNDH2_C PF16858.5 CDI85241.1 - 0.00086 19.3 0.5 0.00086 19.3 0.5 4.3 2 2 1 4 4 4 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term BUD22 PF09073.10 CDI85243.1 - 0.0027 17.1 6.9 0.0027 17.1 6.9 2.2 2 0 0 2 2 2 1 BUD22 SID-1_RNA_chan PF13965.6 CDI85243.1 - 0.011 14.2 1.6 0.019 13.4 1.6 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 CDI85243.1 - 0.33 9.9 3.3 0.56 9.2 3.3 1.3 1 0 0 1 1 1 0 Solute carrier family 12 CPSF100_C PF13299.6 CDI85243.1 - 1.3 9.1 10.0 0.089 13.0 2.6 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Neur_chan_memb PF02932.16 CDI85243.1 - 3.8 7.5 7.4 0.56 10.2 2.7 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Apt1 PF10351.9 CDI85243.1 - 5.5 5.7 36.9 1.1 8.1 27.2 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain PNISR PF15996.5 CDI85243.1 - 6.8 6.9 15.8 1.3 9.2 10.6 1.9 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR NST1 PF13945.6 CDI85243.1 - 8.1 6.5 20.2 2.2 8.3 14.5 2.1 2 0 0 2 2 2 0 Salt tolerance down-regulator CAML PF14963.6 CDI85244.1 - 2.9 8.0 19.2 3.2 7.8 19.2 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Presenilin PF01080.17 CDI85244.1 - 3.3 6.4 44.4 3.8 6.2 44.4 1.1 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI85244.1 - 3.9 7.4 29.6 5.5 6.9 29.6 1.2 1 0 0 1 1 1 0 Protein Family FAM60A TP53IP5 PF15331.6 CDI85244.1 - 5.5 7.1 29.6 6.5 6.9 29.6 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Lin-8 PF03353.15 CDI85244.1 - 6.2 6.3 41.5 7.5 6.0 41.5 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist UPF0016 PF01169.19 CDI85245.1 - 2.3e-06 27.8 16.3 2.3e-06 27.8 16.3 3.2 2 1 0 2 2 1 1 Uncharacterized protein family UPF0016 DUF2722 PF10846.8 CDI85245.1 - 6.5e-05 22.1 12.5 0.00011 21.4 12.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI85245.1 - 0.00016 21.8 21.9 0.00028 21.0 21.9 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CDI85245.1 - 0.013 15.9 4.5 0.021 15.2 4.5 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like Suf PF05843.14 CDI85245.1 - 0.014 15.4 11.0 0.019 15.0 11.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MMR1 PF08505.10 CDI85245.1 - 0.023 15.0 9.5 0.035 14.4 9.5 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SpoIIP PF07454.11 CDI85245.1 - 0.036 13.5 6.4 0.054 13.0 6.4 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Band_3_cyto PF07565.13 CDI85245.1 - 0.069 13.0 2.8 0.09 12.6 2.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TERB2 PF15101.6 CDI85245.1 - 0.071 13.2 8.9 0.11 12.6 8.9 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Lin-8 PF03353.15 CDI85245.1 - 0.09 12.3 12.4 0.52 9.8 12.4 1.8 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist MecA PF05389.12 CDI85245.1 - 0.13 11.9 4.8 0.21 11.2 4.8 1.3 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Presenilin PF01080.17 CDI85245.1 - 0.23 10.2 12.2 0.34 9.6 12.2 1.3 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 CDI85245.1 - 0.24 10.3 12.1 0.3 10.0 12.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4820 PF16091.5 CDI85245.1 - 0.25 10.7 6.4 0.43 9.9 6.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Peroxin-3 PF04882.12 CDI85245.1 - 0.59 9.1 13.7 1 8.2 13.7 1.4 1 0 0 1 1 1 0 Peroxin-3 EOS1 PF12326.8 CDI85245.1 - 0.66 9.9 3.0 1 9.3 3.0 1.3 1 0 0 1 1 1 0 N-glycosylation protein Neur_chan_memb PF02932.16 CDI85245.1 - 0.87 9.6 7.2 0.41 10.7 5.2 1.6 2 0 0 2 2 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 CDI85245.1 - 0.98 8.4 8.0 1.2 8.0 8.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI85245.1 - 1.1 7.5 19.3 1.3 7.2 19.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Connexin PF00029.19 CDI85245.1 - 1.2 8.9 8.0 1.7 8.3 8.0 1.2 1 0 0 1 1 1 0 Connexin MAJIN PF15077.6 CDI85245.1 - 1.5 8.6 7.9 2.2 8.0 7.9 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein OATP PF03137.20 CDI85245.1 - 1.5 7.0 4.4 2.2 6.5 4.4 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family FAM176 PF14851.6 CDI85245.1 - 2.1 8.0 5.9 4.5 6.9 5.9 1.5 1 0 0 1 1 1 0 FAM176 family EIIBC-GUT_N PF03612.14 CDI85245.1 - 2.3 7.9 10.8 5.7 6.6 10.8 1.6 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus RR_TM4-6 PF06459.12 CDI85245.1 - 2.5 7.9 18.4 3.8 7.3 18.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Serinc PF03348.15 CDI85245.1 - 2.6 6.9 3.7 3.4 6.5 3.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF572 PF04502.13 CDI85245.1 - 2.8 7.5 13.9 4.1 6.9 13.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Peptidase_S49_N PF08496.10 CDI85245.1 - 2.9 7.9 12.6 6.2 6.9 12.6 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FAM60A PF15396.6 CDI85245.1 - 3 7.8 9.2 4.7 7.2 9.2 1.3 1 0 0 1 1 1 0 Protein Family FAM60A MDM10 PF12519.8 CDI85245.1 - 3.6 6.3 7.7 5.7 5.7 7.7 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 GET2 PF08690.10 CDI85245.1 - 4 7.0 11.1 7.3 6.2 11.1 1.5 1 0 0 1 1 1 0 GET complex subunit GET2 Hid1 PF12722.7 CDI85245.1 - 4.2 5.4 10.1 5.3 5.0 10.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ALMT PF11744.8 CDI85245.1 - 4.6 6.0 6.7 6.5 5.5 6.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter GREB1 PF15782.5 CDI85245.1 - 4.8 4.2 15.0 5.9 3.9 15.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PCM1_C PF15717.5 CDI85245.1 - 5.3 5.6 13.9 0.013 14.2 3.4 1.8 2 0 0 2 2 2 0 Pericentriolar material 1 C terminus DDRGK PF09756.9 CDI85245.1 - 5.5 6.5 18.5 8.7 5.9 18.5 1.2 1 0 0 1 1 1 0 DDRGK domain DUF2828 PF11443.8 CDI85245.1 - 6.8 4.6 10.8 10 4.0 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Ndc1_Nup PF09531.10 CDI85245.1 - 7.5 5.1 10.3 9.5 4.8 10.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4638 PF15472.6 CDI85245.1 - 7.8 6.2 11.4 11 5.6 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) SARAF PF06682.12 CDI85246.1 - 0.011 15.5 10.8 0.011 15.5 10.8 2.4 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis RskA PF10099.9 CDI85246.1 - 0.02 15.2 10.6 0.02 15.2 10.6 3.7 1 1 2 3 3 3 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI85248.1 - 0.023 15.0 12.6 0.049 13.9 12.6 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI85248.1 - 0.081 11.9 26.7 0.086 11.8 26.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DcuA_DcuB PF03605.14 CDI85248.1 - 0.097 11.5 6.8 0.12 11.2 6.8 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter NARP1 PF12569.8 CDI85248.1 - 0.11 11.4 18.4 0.11 11.4 18.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Activator_LAG-3 PF11498.8 CDI85248.1 - 0.38 9.7 50.8 0.48 9.3 50.8 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Peptidase_S15 PF02129.18 CDI85248.1 - 0.6 9.7 14.3 0.66 9.5 14.3 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) CobT PF06213.12 CDI85248.1 - 0.94 8.8 26.9 1 8.7 26.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PCEMA1 PF07418.11 CDI85248.1 - 1.1 8.7 13.0 1.2 8.6 13.0 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 DUF4746 PF15928.5 CDI85248.1 - 1.4 8.3 15.0 1.4 8.3 15.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) ADP_ribosyl_GH PF03747.14 CDI85248.1 - 1.5 8.5 5.6 1.8 8.2 5.6 1.0 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase PAT1 PF09770.9 CDI85248.1 - 1.9 6.7 32.2 1.9 6.6 32.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SID-1_RNA_chan PF13965.6 CDI85248.1 - 2.2 6.6 10.9 2.3 6.5 10.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI85248.1 - 2.4 7.0 17.9 2.6 6.9 17.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) SprA-related PF12118.8 CDI85248.1 - 2.9 6.9 46.0 3.6 6.6 46.0 1.1 1 0 0 1 1 1 0 SprA-related family Paf1 PF03985.13 CDI85248.1 - 3.1 6.7 24.0 3.6 6.5 24.0 1.1 1 0 0 1 1 1 0 Paf1 XRCC4 PF06632.12 CDI85248.1 - 3.1 6.6 21.5 3.3 6.5 21.5 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 MTP18 PF10558.9 CDI85248.1 - 3.6 7.5 8.1 5 7.0 8.1 1.4 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) Ureide_permease PF07168.11 CDI85248.1 - 4 6.1 9.1 3.9 6.1 9.1 1.2 1 0 0 1 1 1 0 Ureide permease TFIIA PF03153.13 CDI85248.1 - 4.3 7.2 48.4 5.1 7.0 48.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 CDI85248.1 - 5.7 6.7 24.8 6.2 6.6 24.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FPN1 PF06963.12 CDI85248.1 - 8.7 4.8 7.8 10 4.6 7.8 1.2 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Hid1 PF12722.7 CDI85249.1 - 0.1 10.7 11.0 0.1 10.7 11.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NPR3 PF03666.13 CDI85249.1 - 0.12 11.1 13.9 0.22 10.3 13.9 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Apt1 PF10351.9 CDI85249.1 - 0.32 9.8 24.5 0.53 9.1 24.5 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Raftlin PF15250.6 CDI85249.1 - 1.3 7.7 10.7 2 7.1 10.7 1.3 1 0 0 1 1 1 0 Raftlin Presenilin PF01080.17 CDI85250.1 - 4.9e-05 22.3 12.9 5.8e-05 22.0 12.9 1.1 1 0 0 1 1 1 1 Presenilin CPSF100_C PF13299.6 CDI85250.1 - 0.015 15.5 12.0 0.024 14.8 3.4 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF819 PF05684.12 CDI85250.1 - 0.039 13.0 0.0 0.045 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF819) SLC12 PF03522.15 CDI85250.1 - 0.39 9.7 16.0 0.52 9.3 16.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF1676 PF07898.13 CDI85250.1 - 0.83 9.7 8.8 0.57 10.2 7.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1676) DUF775 PF05603.12 CDI85250.1 - 0.84 9.1 20.0 0.081 12.5 7.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF775) CCSAP PF15748.5 CDI85250.1 - 0.86 9.7 20.3 2.7 8.1 1.9 2.0 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Band_3_cyto PF07565.13 CDI85250.1 - 1.3 8.7 20.2 0.39 10.5 7.7 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain G0-G1_switch_2 PF15103.6 CDI85250.1 - 1.4 9.4 11.7 0.77 10.2 3.5 2.2 2 0 0 2 2 2 0 G0/G1 switch protein 2 HA2 PF04408.23 CDI85250.1 - 1.6 9.0 8.3 1 9.7 1.5 2.3 2 0 0 2 2 2 0 Helicase associated domain (HA2) AIF_C PF14721.6 CDI85250.1 - 1.7 9.0 10.7 0.67 10.3 2.5 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term EIIBC-GUT_N PF03612.14 CDI85250.1 - 1.8 8.3 15.1 0.59 9.8 6.8 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus SURF6 PF04935.12 CDI85250.1 - 2.6 7.8 26.2 4.4 7.0 26.2 1.3 1 1 0 1 1 1 0 Surfeit locus protein 6 DUF4770 PF15994.5 CDI85250.1 - 4.2 7.6 20.8 0.21 11.8 7.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Spt20 PF12090.8 CDI85250.1 - 5 6.7 58.8 2.3 7.8 30.6 2.1 2 0 0 2 2 2 0 Spt20 family Peptidase_U57 PF05582.12 CDI85250.1 - 5.7 6.1 15.9 1.2 8.3 5.5 2.0 2 0 0 2 2 2 0 YabG peptidase U57 OSTbeta PF15048.6 CDI85250.1 - 7.3 6.7 9.2 0.96 9.6 1.6 2.1 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein Dfp1_Him1_M PF08630.10 CDI85250.1 - 7.3 6.8 16.7 0.91 9.8 4.0 2.2 2 0 0 2 2 2 0 Dfp1/Him1, central region RSB_motif PF16294.5 CDI85250.1 - 7.4 6.9 21.4 0.18 12.1 8.4 2.4 2 1 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif MTP18 PF10558.9 CDI85250.1 - 7.9 6.4 6.7 2.5 8.0 1.1 2.0 2 0 0 2 2 2 0 Mitochondrial 18 KDa protein (MTP18) DUF1764 PF08576.10 CDI85250.1 - 9.1 7.2 16.4 8 7.4 7.6 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Spt20 PF12090.8 CDI85252.1 - 0.00038 20.1 4.5 0.00038 20.1 4.5 20.4 14 3 3 17 17 17 8 Spt20 family DUF2722 PF10846.8 CDI85252.1 - 0.0018 17.3 4.2 0.0018 17.3 4.2 19.7 17 3 3 20 20 20 12 Protein of unknown function (DUF2722) DUF3883 PF13020.6 CDI85252.1 - 0.057 13.5 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) CNDH2_N PF06278.11 CDI85252.1 - 0.06 13.6 0.1 0.06 13.6 0.1 16.1 17 1 1 18 18 18 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal PTPRCAP PF15713.5 CDI85252.1 - 0.58 10.4 0.0 0.58 10.4 0.0 16.3 15 3 1 16 16 16 0 Protein tyrosine phosphatase receptor type C-associated Clathrin PF00637.20 CDI85253.1 - 0.062 13.2 0.0 0.075 12.9 0.0 1.1 1 0 0 1 1 1 0 Region in Clathrin and VPS Macoilin PF09726.9 CDI85255.1 - 0.032 12.8 2.6 0.038 12.6 2.6 1.1 1 0 0 1 1 1 0 Macoilin family SR-25 PF10500.9 CDI85255.1 - 0.37 10.4 10.1 0.57 9.7 10.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI85255.1 - 1.1 9.5 15.3 1.4 9.1 15.3 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA RIFIN PF02009.16 CDI85255.1 - 2 8.2 9.1 3.9 7.3 9.1 1.5 1 1 0 1 1 1 0 Rifin DUF2722 PF10846.8 CDI85256.1 - 0.0018 17.3 4.6 0.0018 17.3 4.6 32.9 13 7 14 27 27 27 4 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI85256.1 - 0.0027 17.4 4.1 0.0027 17.4 4.1 33.4 9 3 13 22 22 22 3 Spt20 family Arm_vescicular PF18770.1 CDI85257.1 - 4.7 7.2 6.8 1.4 8.9 0.1 3.1 3 0 0 3 3 3 0 Armadillo tether-repeat of vescicular transport factor 7tm_3 PF00003.22 CDI85258.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR Med15 PF09606.10 CDI85259.1 - 0.00028 19.8 4.2 0.0005 18.9 4.2 1.4 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2845 PF11006.8 CDI85259.1 - 0.063 13.4 3.7 0.19 11.8 3.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2845) DivIC PF04977.15 CDI85259.1 - 2.9 7.7 8.5 6 6.7 8.5 1.5 1 0 0 1 1 1 0 Septum formation initiator MDMPI_N PF11716.8 CDI85259.1 - 5.9 7.6 27.9 1.2 9.8 3.2 3.1 2 1 1 3 3 3 0 Mycothiol maleylpyruvate isomerase N-terminal domain ANAPC_CDC26 PF10471.9 CDI85261.1 - 0.0005 20.9 8.5 0.0005 20.9 8.5 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex APC subunit CDC26 SUIM_assoc PF16619.5 CDI85261.1 - 0.0096 16.0 7.2 0.034 14.2 7.2 1.9 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI85261.1 - 0.01 15.5 3.9 0.015 14.9 3.9 1.3 1 0 0 1 1 1 0 Spt20 family BRF1 PF07741.13 CDI85261.1 - 0.025 14.9 1.5 0.076 13.4 1.5 1.8 1 0 0 1 1 1 0 Brf1-like TBP-binding domain TFIIA PF03153.13 CDI85261.1 - 0.034 14.1 4.3 0.066 13.2 4.3 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PEX11 PF05648.14 CDI85261.1 - 0.063 12.7 3.4 0.11 12.0 3.4 1.3 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Med15 PF09606.10 CDI85261.1 - 0.29 9.8 11.9 0.053 12.2 2.3 2.5 3 0 0 3 3 3 0 ARC105 or Med15 subunit of Mediator complex non-fungal CCSAP PF15748.5 CDI85262.1 - 2.8 8.0 66.1 3.9 7.6 66.1 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CLN3 PF02487.17 CDI85264.1 - 2.9 6.9 25.0 0.008 15.3 14.3 2.1 2 1 1 3 3 3 0 CLN3 protein SR-25 PF10500.9 CDI85266.1 - 0.00054 19.7 21.2 0.00054 19.7 21.2 1.6 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Neur_chan_memb PF02932.16 CDI85266.1 - 0.69 9.9 8.1 1.1 9.3 8.1 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM199X PF15814.5 CDI85266.1 - 6.6 5.7 19.1 12 4.8 19.1 1.3 1 0 0 1 1 1 0 Protein family FAM199X DUF4148 PF13663.6 CDI85267.1 - 0.6 10.3 0.1 0.6 10.3 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) DcuA_DcuB PF03605.14 CDI85268.1 - 0.0083 15.1 1.7 0.0099 14.8 1.7 1.0 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter Connexin PF00029.19 CDI85268.1 - 0.0086 15.9 1.5 0.01 15.6 1.5 1.1 1 0 0 1 1 1 1 Connexin RskA PF10099.9 CDI85268.1 - 0.0093 16.3 13.2 0.012 15.9 13.2 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI85268.1 - 0.013 15.5 22.4 0.015 15.4 22.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit G0-G1_switch_2 PF15103.6 CDI85268.1 - 0.019 15.4 1.2 0.019 15.4 0.3 1.5 2 0 0 2 2 2 0 G0/G1 switch protein 2 CLN3 PF02487.17 CDI85268.1 - 0.02 13.9 1.0 0.02 14.0 1.0 1.1 1 0 0 1 1 1 0 CLN3 protein Presenilin PF01080.17 CDI85268.1 - 0.021 13.6 3.8 0.022 13.5 3.8 1.1 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CDI85268.1 - 0.025 14.6 6.5 0.021 14.8 6.5 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) EOS1 PF12326.8 CDI85268.1 - 0.03 14.3 1.7 0.035 14.0 1.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein eIF_4EBP PF05456.11 CDI85268.1 - 0.036 14.0 2.4 0.056 13.4 2.4 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) OATP PF03137.20 CDI85268.1 - 0.036 12.4 1.6 0.036 12.4 1.6 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Erv26 PF04148.13 CDI85268.1 - 0.058 13.2 0.4 0.068 13.0 0.4 1.1 1 0 0 1 1 1 0 Transmembrane adaptor Erv26 DUF4834 PF16118.5 CDI85268.1 - 0.072 14.1 5.7 0.11 13.5 5.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 CDI85268.1 - 0.2 12.6 2.3 0.35 11.8 2.3 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain FHIPEP PF00771.20 CDI85268.1 - 0.23 9.9 3.5 0.23 9.9 3.5 1.1 1 0 0 1 1 1 0 FHIPEP family Neur_chan_memb PF02932.16 CDI85268.1 - 0.28 11.2 1.9 0.27 11.2 1.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MCR_alpha PF02249.17 CDI85268.1 - 0.28 11.6 2.6 0.49 10.9 2.6 1.4 1 0 0 1 1 1 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain PigN PF04987.14 CDI85268.1 - 0.45 9.3 2.2 0.43 9.4 2.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) TMEM208_SND2 PF05620.11 CDI85268.1 - 0.58 9.9 5.6 0.47 10.2 4.4 1.4 1 1 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 Ribosomal_60s PF00428.19 CDI85268.1 - 0.93 10.1 12.3 0.14 12.8 8.7 1.5 2 0 0 2 2 1 0 60s Acidic ribosomal protein EIIBC-GUT_N PF03612.14 CDI85268.1 - 4.6 6.9 8.2 6.6 6.4 7.5 1.6 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus RAP1 PF07218.11 CDI85269.1 - 1.9 6.7 9.1 2.2 6.5 9.1 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4692 PF15763.5 CDI85270.1 - 0.00018 22.0 7.7 0.0056 17.2 0.3 2.2 2 0 0 2 2 2 2 Regulator of human erythroid cell expansion (RHEX) SR-25 PF10500.9 CDI85270.1 - 0.0014 18.3 17.8 0.017 14.7 6.3 2.1 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein Apt1 PF10351.9 CDI85270.1 - 0.01 14.7 2.1 0.012 14.5 2.1 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 CDI85270.1 - 0.046 13.6 2.6 0.052 13.5 2.6 1.1 1 0 0 1 1 1 0 SPX domain EBP50_C PF09007.11 CDI85270.1 - 0.11 13.5 8.9 1.1 10.3 0.3 2.2 2 0 0 2 2 2 0 EBP50, C-terminal Sporozoite_P67 PF05642.11 CDI85270.1 - 0.47 8.5 6.8 0.61 8.1 6.8 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CCSAP PF15748.5 CDI85270.1 - 1 9.5 8.5 5.1 7.2 3.6 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated SARAF PF06682.12 CDI85270.1 - 3.3 7.2 11.1 6.8 6.2 11.1 1.5 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF1635 PF07795.11 CDI85270.1 - 3.8 7.3 10.5 11 5.8 4.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DUF4171 PF13775.6 CDI85270.1 - 5.8 7.4 15.8 11 6.5 4.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4171) Dehydrin PF00257.19 CDI85270.1 - 6.1 7.4 21.4 0.33 11.5 3.0 3.1 3 0 0 3 3 3 0 Dehydrin DUF4010 PF13194.6 CDI85271.1 - 0.0015 18.3 0.3 0.0032 17.2 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4010) SLC12 PF03522.15 CDI85271.1 - 0.083 11.9 53.5 0.098 11.7 53.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF572 PF04502.13 CDI85271.1 - 0.17 11.5 41.1 0.27 10.8 41.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Hid1 PF12722.7 CDI85271.1 - 0.61 8.2 50.4 0.74 7.9 50.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SpoIIIAH PF12685.7 CDI85271.1 - 0.7 9.7 48.4 1.1 9.0 48.4 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Apt1 PF10351.9 CDI85271.1 - 3.3 6.5 34.8 4.4 6.1 34.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain LYRIC PF15686.5 CDI85271.1 - 3.8 7.0 39.0 5 6.6 39.0 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Choline_transpo PF04515.12 CDI85271.1 - 6.9 5.8 6.2 9.5 5.3 6.1 1.5 1 1 0 1 1 1 0 Plasma-membrane choline transporter RskA PF10099.9 CDI85272.1 - 0.0025 18.1 1.7 0.0025 18.1 1.7 3.7 1 1 1 2 2 2 1 Anti-sigma-K factor rskA AdenylateSensor PF16579.5 CDI85272.1 - 0.042 14.3 0.5 0.042 14.3 0.5 2.9 1 1 0 2 2 2 0 Adenylate sensor of SNF1-like protein kinase PPP4R2 PF09184.11 CDI85272.1 - 3.1 7.3 46.3 5.3 6.5 46.3 1.4 1 0 0 1 1 1 0 PPP4R2 DUF2126 PF09899.9 CDI85273.1 - 0.0076 14.4 7.7 0.0086 14.2 7.7 1.1 1 0 0 1 1 1 1 Putative amidoligase enzyme (DUF2126) RskA PF10099.9 CDI85273.1 - 0.011 16.0 2.4 0.011 16.0 2.4 3.9 1 1 2 3 3 1 0 Anti-sigma-K factor rskA RR_TM4-6 PF06459.12 CDI85273.1 - 0.02 14.7 15.8 0.025 14.4 15.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI85273.1 - 0.022 13.0 32.3 0.024 12.9 32.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ALMT PF11744.8 CDI85273.1 - 0.025 13.4 12.9 0.03 13.2 12.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4045 PF13254.6 CDI85273.1 - 0.033 13.9 15.1 0.038 13.6 15.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF572 PF04502.13 CDI85273.1 - 0.034 13.8 17.1 0.042 13.5 17.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) MIIP PF15734.5 CDI85273.1 - 0.037 13.5 16.4 0.049 13.1 16.4 1.3 1 0 0 1 1 1 0 Migration and invasion-inhibitory CCSAP PF15748.5 CDI85273.1 - 0.05 13.8 23.0 0.068 13.3 23.0 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF913 PF06025.12 CDI85273.1 - 0.067 12.2 8.9 0.082 11.9 8.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) MDM10 PF12519.8 CDI85273.1 - 0.067 12.0 11.9 0.087 11.7 11.9 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 FAM60A PF15396.6 CDI85273.1 - 0.19 11.7 13.9 0.26 11.3 13.9 1.4 1 0 0 1 1 1 0 Protein Family FAM60A SARAF PF06682.12 CDI85273.1 - 0.26 10.9 16.7 0.48 10.0 16.7 1.6 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Velvet PF11754.8 CDI85273.1 - 0.27 11.1 20.4 0.38 10.6 20.4 1.3 1 0 0 1 1 1 0 Velvet factor CDC45 PF02724.14 CDI85273.1 - 0.29 9.4 14.8 0.37 9.0 14.8 1.1 1 0 0 1 1 1 0 CDC45-like protein V_ATPase_I PF01496.19 CDI85273.1 - 0.3 9.0 17.0 0.44 8.4 17.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PA26 PF04636.13 CDI85273.1 - 0.32 9.9 14.2 0.39 9.6 14.2 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SLC12 PF03522.15 CDI85273.1 - 0.35 9.8 21.0 0.42 9.6 21.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI85273.1 - 0.61 10.1 18.8 0.86 9.6 18.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 CDI85273.1 - 0.63 8.1 20.6 0.76 7.8 20.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Tam41_Mmp37 PF09139.11 CDI85273.1 - 1 8.8 15.6 1.4 8.3 15.6 1.2 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial Spore_coat_CotO PF14153.6 CDI85273.1 - 1.2 9.0 26.1 2 8.3 26.1 1.4 1 0 0 1 1 1 0 Spore coat protein CotO Tom22 PF04281.13 CDI85273.1 - 1.2 8.9 18.8 0.36 10.6 2.8 2.6 3 0 0 3 3 2 0 Mitochondrial import receptor subunit Tom22 Peptidase_S64 PF08192.11 CDI85273.1 - 1.6 7.1 15.5 1.7 7.1 15.5 1.2 1 0 0 1 1 1 0 Peptidase family S64 SKA1 PF07160.12 CDI85273.1 - 1.8 8.4 23.8 2.3 8.0 23.8 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 HCO3_cotransp PF00955.21 CDI85273.1 - 2.2 7.0 7.8 3.1 6.5 7.8 1.2 1 0 0 1 1 1 0 HCO3- transporter family Dicty_REP PF05086.12 CDI85273.1 - 2.2 6.1 11.6 2.4 6.0 11.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Membralin PF09746.9 CDI85273.1 - 2.3 7.2 12.2 2.9 6.8 12.2 1.2 1 0 0 1 1 1 0 Tumour-associated protein LMBR1 PF04791.16 CDI85273.1 - 3 6.6 10.5 3.9 6.3 10.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Sin_N PF04801.13 CDI85273.1 - 3.6 6.7 32.0 4.5 6.4 32.0 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Paramyxo_ncap PF00973.19 CDI85273.1 - 3.9 6.3 16.0 4.5 6.1 16.0 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PNISR PF15996.5 CDI85273.1 - 4.1 7.6 29.4 6.5 7.0 29.4 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR GREB1 PF15782.5 CDI85273.1 - 4.4 4.3 23.0 4.2 4.3 23.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer O-antigen_lig PF13425.6 CDI85273.1 - 4.8 5.8 7.9 6.4 5.4 7.9 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein NPR3 PF03666.13 CDI85273.1 - 6.7 5.4 22.3 9.1 4.9 22.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Cellulose_synt PF03552.14 CDI85273.1 - 8.4 4.7 5.9 10 4.5 5.9 1.2 1 0 0 1 1 1 0 Cellulose synthase SelP_N PF04592.14 CDI85274.1 - 0.00029 20.3 31.3 0.00053 19.5 31.3 1.5 1 0 0 1 1 1 1 Selenoprotein P, N terminal region PAT1 PF09770.9 CDI85274.1 - 0.003 15.9 24.8 0.003 15.9 24.8 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Exonuc_VII_L PF02601.15 CDI85274.1 - 0.0038 16.8 9.2 0.0051 16.4 9.2 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit Macoilin PF09726.9 CDI85274.1 - 0.017 13.8 14.2 0.025 13.1 14.2 1.3 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI85274.1 - 0.03 14.3 33.7 0.038 14.0 33.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI85274.1 - 0.031 13.0 14.4 0.033 13.0 14.4 1.1 1 0 0 1 1 1 0 Presenilin DUF5427 PF10310.9 CDI85274.1 - 0.031 13.2 14.3 0.034 13.1 14.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) CCSAP PF15748.5 CDI85274.1 - 0.034 14.3 20.6 0.042 14.0 20.6 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CDC45 PF02724.14 CDI85274.1 - 0.035 12.4 6.0 0.041 12.2 6.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 CDI85274.1 - 0.041 13.1 13.9 0.046 12.9 13.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SLC12 PF03522.15 CDI85274.1 - 0.068 12.2 8.2 0.069 12.2 8.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Band_3_cyto PF07565.13 CDI85274.1 - 0.069 13.0 7.5 0.071 12.9 7.5 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FAM76 PF16046.5 CDI85274.1 - 0.085 12.2 13.7 0.11 11.8 13.7 1.2 1 0 0 1 1 1 0 FAM76 protein DUF3984 PF13136.6 CDI85274.1 - 0.12 11.7 20.8 0.17 11.2 20.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) Neur_chan_memb PF02932.16 CDI85274.1 - 0.15 12.1 10.0 0.18 11.8 10.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 CDI85274.1 - 0.16 11.8 13.3 0.22 11.3 13.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Connexin PF00029.19 CDI85274.1 - 0.17 11.6 10.1 0.24 11.2 10.1 1.2 1 0 0 1 1 1 0 Connexin MDM10 PF12519.8 CDI85274.1 - 0.23 10.3 6.7 0.23 10.3 6.7 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF1387 PF07139.11 CDI85274.1 - 0.26 11.0 10.4 0.3 10.8 10.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) FHIPEP PF00771.20 CDI85274.1 - 0.28 9.6 1.3 0.37 9.2 1.3 1.2 1 0 0 1 1 1 0 FHIPEP family TMEM247 PF15444.6 CDI85274.1 - 0.29 11.1 7.5 0.44 10.6 7.5 1.3 1 0 0 1 1 1 0 Transmembrane protein 247 Spem1 PF15670.5 CDI85274.1 - 0.3 10.6 13.3 0.36 10.4 13.3 1.4 1 0 0 1 1 1 0 Spermatid maturation protein 1 DUF4551 PF15087.6 CDI85274.1 - 0.31 9.8 13.6 0.36 9.6 13.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF3292 PF11696.8 CDI85274.1 - 0.52 8.6 12.4 0.6 8.4 12.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Hamartin PF04388.12 CDI85274.1 - 0.75 8.4 19.7 0.84 8.2 19.7 1.1 1 0 0 1 1 1 0 Hamartin protein SPX PF03105.19 CDI85274.1 - 0.76 9.6 16.7 0.82 9.5 16.7 1.1 1 0 0 1 1 1 0 SPX domain YjbH PF06082.11 CDI85274.1 - 0.99 8.1 7.8 1.1 8.0 7.8 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Pox_Ag35 PF03286.14 CDI85274.1 - 1 9.1 9.6 1.6 8.4 9.6 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein AF-4 PF05110.13 CDI85274.1 - 1.1 7.2 27.0 1.2 7.1 27.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein EOS1 PF12326.8 CDI85274.1 - 1.4 8.8 4.3 2 8.3 4.3 1.4 1 0 0 1 1 1 0 N-glycosylation protein Nucleo_P87 PF07267.11 CDI85274.1 - 1.8 7.3 18.5 2.2 7.1 18.5 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SMYLE_N PF18615.1 CDI85274.1 - 2.2 7.7 14.0 2.9 7.4 14.0 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Endostatin PF06482.11 CDI85274.1 - 2.5 7.5 18.9 3.1 7.2 18.9 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin VIR_N PF15912.5 CDI85274.1 - 2.6 7.6 12.7 3.1 7.3 12.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DUF4175 PF13779.6 CDI85274.1 - 4.5 5.1 25.6 5.8 4.7 25.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Serinc PF03348.15 CDI85274.1 - 4.5 6.1 5.4 6.7 5.5 5.4 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) Otopetrin PF03189.13 CDI85274.1 - 4.7 5.9 9.5 5.8 5.6 9.5 1.2 1 0 0 1 1 1 0 Otopetrin AIF_C PF14721.6 CDI85274.1 - 4.8 7.5 14.2 2 8.8 11.2 1.8 1 1 1 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term V_ATPase_I PF01496.19 CDI85274.1 - 5.3 4.8 18.1 6.4 4.6 18.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S49_N PF08496.10 CDI85274.1 - 5.5 7.0 9.0 9.2 6.3 9.0 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal eIF-3_zeta PF05091.12 CDI85274.1 - 6.3 5.6 14.1 7.7 5.4 14.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CLN3 PF02487.17 CDI85274.1 - 7.3 5.5 10.5 10 5.1 10.5 1.2 1 0 0 1 1 1 0 CLN3 protein PRCC PF10253.9 CDI85274.1 - 8.6 7.1 27.8 13 6.5 27.7 1.5 1 1 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Sec62 PF03839.16 CDI85274.1 - 9.3 5.7 10.3 12 5.3 10.3 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4179 PF13786.6 CDI85276.1 - 0.061 13.8 2.0 0.12 12.9 2.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) TraT PF05818.12 CDI85277.1 - 0.0047 16.7 12.3 0.0047 16.7 12.3 2.1 2 0 0 2 2 2 1 Enterobacterial TraT complement resistance protein SARAF PF06682.12 CDI85277.1 - 0.006 16.3 8.9 0.0071 16.0 8.9 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Spt20 PF12090.8 CDI85277.1 - 0.028 14.0 54.3 0.11 12.2 19.9 2.1 2 0 0 2 2 2 0 Spt20 family PAT1 PF09770.9 CDI85277.1 - 0.057 11.7 31.8 0.067 11.5 31.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TERB2 PF15101.6 CDI85277.1 - 0.084 12.9 25.8 0.31 11.1 9.1 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 SLC12 PF03522.15 CDI85277.1 - 0.16 11.0 14.9 0.19 10.7 14.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RIFIN PF02009.16 CDI85277.1 - 0.19 11.6 22.4 0.28 11.0 22.4 1.2 1 0 0 1 1 1 0 Rifin Activator_LAG-3 PF11498.8 CDI85277.1 - 0.26 10.2 57.5 0.3 10.0 57.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TCP PF03634.13 CDI85277.1 - 0.84 10.2 18.0 1.5 9.4 6.2 2.1 2 0 0 2 2 2 0 TCP family transcription factor DcuA_DcuB PF03605.14 CDI85277.1 - 1 8.2 20.7 0.67 8.8 12.3 2.0 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter DUF4820 PF16091.5 CDI85277.1 - 1 8.7 16.0 1.2 8.5 3.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) ATAD4 PF15321.6 CDI85277.1 - 1.1 10.7 10.1 4.6 8.6 0.7 2.3 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 ALMT PF11744.8 CDI85277.1 - 1.4 7.7 13.7 1.6 7.5 13.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Sporozoite_P67 PF05642.11 CDI85277.1 - 1.6 6.8 9.2 1.9 6.5 9.2 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4207 PF13904.6 CDI85277.1 - 1.6 8.3 34.9 0.049 13.3 9.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) Tic110 PF16940.5 CDI85277.1 - 1.7 7.0 22.4 0.1 11.1 15.5 2.0 2 0 0 2 2 2 0 Chloroplast envelope transporter SPG4 PF17325.2 CDI85277.1 - 2.1 9.5 13.0 5.7 8.1 2.6 2.3 2 0 0 2 2 2 0 Stationary phase protein 4 TT_ORF2 PF02957.15 CDI85277.1 - 2.1 9.3 13.4 3.8 8.4 1.7 2.3 2 0 0 2 2 2 0 TT viral ORF2 RAB3GAP2_N PF14655.6 CDI85277.1 - 2.4 7.3 21.6 1 8.6 8.4 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Hid1 PF12722.7 CDI85277.1 - 2.6 6.1 15.0 3 5.9 15.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FA_desaturase PF00487.24 CDI85277.1 - 2.8 7.7 4.6 3.5 7.4 1.7 2.0 1 1 1 2 2 2 0 Fatty acid desaturase CNDH2_N PF06278.11 CDI85277.1 - 3.1 8.0 17.2 3 8.1 5.3 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Thg1C PF14413.6 CDI85277.1 - 4.1 7.6 15.1 4.8 7.4 3.0 2.2 2 0 0 2 2 2 0 Thg1 C terminal domain Roughex PF06020.11 CDI85277.1 - 4.5 6.3 28.1 0.73 8.9 8.4 2.1 2 0 0 2 2 2 0 Drosophila roughex protein ORC_WH_C PF18137.1 CDI85277.1 - 6.6 6.8 16.6 4.9 7.2 3.7 2.2 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal U1snRNP70_N PF12220.8 CDI85277.1 - 9.1 7.0 19.0 3.3 8.4 4.6 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Spt20 PF12090.8 CDI85278.1 - 0.015 14.9 46.1 0.017 14.8 46.1 1.1 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI85278.1 - 0.062 14.3 24.3 0.085 13.8 24.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2722 PF10846.8 CDI85278.1 - 0.52 9.2 39.5 0.66 8.8 39.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Gti1_Pac2 PF09729.9 CDI85278.1 - 0.93 9.6 21.3 1.1 9.3 21.3 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family Pex14_N PF04695.13 CDI85278.1 - 1 10.0 25.0 1.1 9.9 25.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF5308 PF17233.2 CDI85278.1 - 1.3 9.2 16.0 1.5 9.0 16.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5308) SpoIIP PF07454.11 CDI85278.1 - 1.8 8.0 23.8 2 7.8 23.8 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FTZ PF03867.14 CDI85278.1 - 1.9 8.0 13.8 2.5 7.6 13.8 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region CTNNB1_binding PF08347.11 CDI85278.1 - 2.2 8.4 16.4 2.5 8.2 16.4 1.0 1 0 0 1 1 1 0 N-terminal CTNNB1 binding Endostatin PF06482.11 CDI85278.1 - 2.3 7.6 17.8 2.4 7.5 17.8 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Presenilin PF01080.17 CDI85278.1 - 2.3 6.9 26.2 2.5 6.8 26.2 1.0 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI85278.1 - 2.3 8.1 43.6 2.5 8.0 43.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4746 PF15928.5 CDI85278.1 - 2.6 7.4 21.6 2.9 7.2 21.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CobT PF06213.12 CDI85278.1 - 2.7 7.3 33.8 3.1 7.1 33.8 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Eapp_C PF10238.9 CDI85278.1 - 3.2 7.8 20.3 4.1 7.5 20.3 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein EFTUD2 PF16004.5 CDI85278.1 - 3.4 8.3 23.0 4.1 8.0 23.0 1.2 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus CCDC53 PF10152.9 CDI85278.1 - 3.5 8.0 22.2 3.9 7.9 22.2 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Ureide_permease PF07168.11 CDI85278.1 - 3.9 6.1 13.1 4.2 6.0 13.1 1.0 1 0 0 1 1 1 0 Ureide permease CPSF100_C PF13299.6 CDI85278.1 - 3.9 7.6 20.5 4.7 7.4 20.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF1764 PF08576.10 CDI85278.1 - 4.5 8.2 18.5 5.8 7.9 18.5 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF4820 PF16091.5 CDI85278.1 - 4.6 6.5 18.8 5.5 6.3 18.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) EPL1 PF10513.9 CDI85278.1 - 5 7.5 23.4 6.9 7.0 23.4 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like FYDLN_acid PF09538.10 CDI85278.1 - 5.2 7.8 14.5 6.7 7.4 14.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Afi1 PF07792.12 CDI85278.1 - 5.6 7.4 20.4 6.6 7.2 20.4 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DDHD PF02862.17 CDI85278.1 - 6.1 6.9 19.9 6.4 6.9 19.9 1.1 1 0 0 1 1 1 0 DDHD domain Paf1 PF03985.13 CDI85278.1 - 6.3 5.7 28.5 6.2 5.7 28.5 1.1 1 0 0 1 1 1 0 Paf1 TERB2 PF15101.6 CDI85278.1 - 6.3 6.8 27.5 7 6.6 27.5 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF3464 PF11947.8 CDI85278.1 - 6.4 6.5 19.5 8.1 6.2 19.5 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 FAM176 PF14851.6 CDI85278.1 - 7.1 6.3 18.9 8.4 6.0 18.9 1.1 1 0 0 1 1 1 0 FAM176 family MMU163 PF17119.5 CDI85278.1 - 8 5.5 11.0 9.8 5.3 11.0 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis GNAT_acetyltr_2 PF13718.6 CDI85278.1 - 8.1 5.8 14.4 11 5.4 14.4 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Slu7 PF11708.8 CDI85278.1 - 8.6 6.0 25.6 9.9 5.8 25.6 1.0 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor Suf PF05843.14 CDI85278.1 - 8.7 6.2 22.3 11 5.9 22.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Band_3_cyto PF07565.13 CDI85278.1 - 9.2 6.0 19.8 10 5.8 19.8 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Med19 PF10278.9 CDI85278.1 - 9.5 6.1 16.7 10 6.0 16.7 1.0 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Tim54 PF11711.8 CDI85278.1 - 9.8 4.8 22.4 11 4.7 22.4 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 START PF01852.19 CDI85279.1 - 4.3e-09 36.1 0.0 5.3e-05 22.7 0.0 2.3 2 0 0 2 2 2 2 START domain DUF3364 PF11844.8 CDI85281.1 - 0.066 13.5 0.0 0.097 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3364) ASFV_J13L PF05568.11 CDI85282.1 - 0.19 11.5 8.3 0.27 10.9 8.3 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein Band_3_cyto PF07565.13 CDI85282.1 - 0.75 9.5 7.2 0.81 9.4 7.2 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SLC12 PF03522.15 CDI85282.1 - 6.4 5.7 10.8 6.2 5.7 10.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 ASC PF00858.24 CDI85283.1 - 1.5 7.7 11.1 2.1 7.2 11.1 1.2 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Glyco_hydro_31 PF01055.26 CDI85283.1 - 1.8 7.7 8.3 2 7.5 8.3 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 31 YL1 PF05764.13 CDI85283.1 - 3.5 7.7 46.0 4.3 7.4 46.0 1.1 1 0 0 1 1 1 0 YL1 nuclear protein EBP50_C PF09007.11 CDI85283.1 - 5.6 8.0 25.7 0.62 11.0 4.8 2.1 2 0 0 2 2 2 0 EBP50, C-terminal FAM176 PF14851.6 CDI85283.1 - 7.9 6.1 27.7 0.49 10.1 3.8 2.4 2 0 0 2 2 2 0 FAM176 family Arg_decarbox_C PF17944.1 CDI85284.1 - 0.13 12.9 0.3 35 5.0 0.0 3.1 3 0 0 3 3 3 0 Arginine decarboxylase C-terminal helical extension Peptidase_M16_C PF05193.21 CDI85286.1 - 8.2e-26 91.1 0.3 4.3e-14 52.9 0.0 4.0 3 2 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CDI85286.1 - 1.4e-16 60.8 0.5 1e-14 54.8 0.7 2.8 2 1 0 2 2 2 1 Insulinase (Peptidase family M16) ALAD PF00490.21 CDI85287.1 - 1.6e-128 428.4 0.0 1.9e-128 428.1 0.0 1.1 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase RNA_pol_3_Rpc31 PF11705.8 CDI85287.1 - 0.13 12.5 13.1 0.23 11.7 13.1 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 CDI85287.1 - 1.9 6.6 6.6 2.5 6.2 6.6 1.1 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 CDI85287.1 - 5.1 6.7 7.5 8.7 6.0 7.5 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein AP2 PF00847.20 CDI85288.1 - 4.3e-06 26.9 0.1 1.1e-05 25.6 0.1 1.7 1 0 0 1 1 1 1 AP2 domain Methyltransf_31 PF13847.6 CDI85289.1 - 7.8e-10 38.7 0.1 3.5e-06 26.9 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 CDI85289.1 - 8.8e-08 32.8 0.1 3.4e-07 30.9 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI85289.1 - 1.4e-07 31.5 0.2 6.5e-07 29.3 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDI85289.1 - 2e-07 31.5 0.0 5.7e-06 26.9 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI85289.1 - 0.00025 21.7 0.2 0.0015 19.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain DDHD PF02862.17 CDI85289.1 - 0.0052 17.0 0.2 2.3 8.3 0.1 2.2 2 0 0 2 2 2 2 DDHD domain MTS PF05175.14 CDI85289.1 - 0.013 15.0 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Pex14_N PF04695.13 CDI85289.1 - 0.061 14.0 6.4 0.85 10.3 1.0 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PrmA PF06325.13 CDI85289.1 - 0.1 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) SpoIIIAH PF12685.7 CDI85289.1 - 0.11 12.3 2.8 2.2 8.0 0.0 2.2 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF4228 PF14009.6 CDI85289.1 - 0.82 10.0 8.6 3.7 7.9 3.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) SUIM_assoc PF16619.5 CDI85289.1 - 1.6 8.9 15.5 0.061 13.4 9.0 2.2 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF1180 PF06679.12 CDI85289.1 - 4.2 7.8 7.9 3.2 8.1 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Corona_nucleoca PF00937.18 CDI85289.1 - 7.4 5.5 14.4 0.18 10.8 6.8 1.9 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein 3HCDH_N PF02737.18 CDI85290.1 - 6e-40 137.0 0.2 2.5e-39 135.0 0.2 1.8 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CDI85290.1 - 8.9e-35 119.2 0.0 2e-34 118.1 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PTP_N PF12453.8 CDI85290.1 - 0.00024 20.7 0.2 0.023 14.4 0.0 2.5 2 0 0 2 2 2 1 Protein tyrosine phosphatase N terminal Methyltransf_25 PF13649.6 CDI85290.1 - 0.084 13.6 0.0 0.21 12.3 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain DUF2946 PF11162.8 CDI85291.1 - 0.11 13.2 1.8 0.17 12.6 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2946) RR_TM4-6 PF06459.12 CDI85292.1 - 0.0014 18.5 36.9 0.0015 18.4 18.4 3.1 3 0 0 3 3 3 1 Ryanodine Receptor TM 4-6 PTPRCAP PF15713.5 CDI85292.1 - 0.0038 17.5 14.9 0.0038 17.5 14.9 3.4 3 1 0 3 3 2 1 Protein tyrosine phosphatase receptor type C-associated CPSF100_C PF13299.6 CDI85292.1 - 0.0097 16.1 34.0 0.45 10.7 15.3 3.6 3 0 0 3 3 3 3 Cleavage and polyadenylation factor 2 C-terminal Peptidase_S49_N PF08496.10 CDI85292.1 - 0.011 15.9 27.3 0.2 11.7 18.7 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal FAM60A PF15396.6 CDI85292.1 - 0.011 15.8 39.1 0.35 10.8 3.6 3.1 3 0 0 3 3 3 0 Protein Family FAM60A eIF-3_zeta PF05091.12 CDI85292.1 - 0.042 12.8 47.3 0.049 12.6 25.3 3.1 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Zip PF02535.22 CDI85292.1 - 0.07 12.3 31.8 0.43 9.7 14.0 3.1 3 0 0 3 3 3 0 ZIP Zinc transporter CCSAP PF15748.5 CDI85292.1 - 0.088 13.0 55.5 0.058 13.6 23.1 3.1 3 0 0 3 3 3 0 Centriole, cilia and spindle-associated Kei1 PF08552.11 CDI85292.1 - 0.23 11.3 41.3 0.063 13.2 10.9 3.5 3 0 0 3 3 3 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4050 PF13259.6 CDI85292.1 - 0.36 11.1 44.1 1.3 9.3 3.7 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4050) MAP7 PF05672.11 CDI85292.1 - 0.49 10.1 55.5 0.66 9.7 39.6 2.3 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Pkinase_fungal PF17667.1 CDI85292.1 - 0.61 8.8 27.7 0.32 9.7 5.4 3.1 3 0 0 3 3 3 0 Fungal protein kinase SID-1_RNA_chan PF13965.6 CDI85292.1 - 0.69 8.3 23.5 0.04 12.3 6.7 3.0 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 Endostatin PF06482.11 CDI85292.1 - 0.8 9.1 38.7 0.84 9.0 17.2 3.1 3 0 0 3 3 3 0 Collagenase NC10 and Endostatin CLN3 PF02487.17 CDI85292.1 - 0.84 8.6 30.8 0.047 12.7 13.0 3.1 3 0 0 3 3 3 0 CLN3 protein Connexin PF00029.19 CDI85292.1 - 0.96 9.2 29.5 0.98 9.1 15.8 3.4 3 0 0 3 3 3 0 Connexin MCM_bind PF09739.9 CDI85292.1 - 1.1 7.7 42.1 0.45 8.9 0.4 3.2 3 0 0 3 3 3 0 Mini-chromosome maintenance replisome factor DUF913 PF06025.12 CDI85292.1 - 1.7 7.5 35.0 1 8.2 13.2 3.2 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) EOS1 PF12326.8 CDI85292.1 - 1.9 8.4 32.0 0.11 12.4 9.9 3.3 3 0 0 3 3 3 0 N-glycosylation protein DUF572 PF04502.13 CDI85292.1 - 2 7.9 47.4 0.12 11.9 17.0 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF572) DUF3807 PF12720.7 CDI85292.1 - 2.2 8.5 56.5 0.28 11.4 26.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) NPR3 PF03666.13 CDI85292.1 - 2.2 7.0 51.4 1 8.1 3.2 3.1 3 0 0 3 3 3 0 Nitrogen Permease regulator of amino acid transport activity 3 SAPS PF04499.15 CDI85292.1 - 2.4 6.9 33.1 1.4 7.6 12.7 3.0 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein Apt1 PF10351.9 CDI85292.1 - 2.9 6.7 46.1 0.091 11.6 8.6 3.1 3 0 0 3 3 3 0 Golgi-body localisation protein domain PAT1 PF09770.9 CDI85292.1 - 3.2 5.9 59.9 0.015 13.6 33.6 2.7 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 SRP-alpha_N PF04086.13 CDI85292.1 - 3.9 7.3 42.7 0.33 10.8 16.7 3.2 3 0 0 3 3 3 0 Signal recognition particle, alpha subunit, N-terminal TP53IP5 PF15331.6 CDI85292.1 - 4.2 7.5 36.3 4.7 7.3 5.8 3.3 3 0 0 3 3 3 0 Cellular tumour antigen p53-inducible 5 CobT PF06213.12 CDI85292.1 - 4.3 6.6 54.9 4 6.8 0.5 3.2 3 0 0 3 3 3 0 Cobalamin biosynthesis protein CobT Tim54 PF11711.8 CDI85292.1 - 4.6 5.9 36.9 1.3 7.7 16.7 3.2 3 0 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 GAGA_bind PF06217.12 CDI85292.1 - 5.9 7.1 32.3 1.7 8.8 18.5 2.7 3 0 0 3 3 3 0 GAGA binding protein-like family SprA-related PF12118.8 CDI85292.1 - 6.1 5.9 97.2 0.37 9.9 21.3 3.2 3 0 0 3 3 3 0 SprA-related family NARP1 PF12569.8 CDI85292.1 - 6.8 5.5 33.3 7 5.4 2.1 2.3 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Otopetrin PF03189.13 CDI85292.1 - 7.3 5.3 24.9 0.048 12.5 3.0 3.1 3 0 0 3 3 3 0 Otopetrin Isy1 PF06246.12 CDI85292.1 - 9.4 5.7 33.8 0.88 9.1 16.6 3.1 3 0 0 3 3 3 0 Isy1-like splicing family Med15 PF09606.10 CDI85294.1 - 0.33 9.6 21.5 0.51 9.0 21.5 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal KBP_C PF12309.8 CDI85295.1 - 0.0036 16.9 12.7 0.0038 16.8 12.7 1.0 1 0 0 1 1 1 1 KIF-1 binding protein C terminal U1snRNP70_N PF12220.8 CDI85295.1 - 0.12 13.0 18.9 0.62 10.7 2.1 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4050 PF13259.6 CDI85295.1 - 0.14 12.5 15.4 0.16 12.3 15.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) DUF4484 PF14831.6 CDI85295.1 - 0.24 11.4 12.1 0.35 10.9 12.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) Sin_N PF04801.13 CDI85295.1 - 0.29 10.3 26.2 0.35 10.0 26.2 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region OAD_gamma PF04277.13 CDI85295.1 - 0.41 11.3 2.2 21 5.8 0.1 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Gti1_Pac2 PF09729.9 CDI85295.1 - 0.42 10.7 13.4 0.49 10.5 13.4 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Folliculin PF11704.8 CDI85295.1 - 0.45 10.4 11.0 0.63 9.9 11.0 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Presenilin PF01080.17 CDI85295.1 - 0.45 9.2 20.1 0.54 9.0 20.1 1.0 1 0 0 1 1 1 0 Presenilin WRNPLPNID PF15017.6 CDI85295.1 - 0.62 11.0 16.1 1.2 10.0 3.2 2.1 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box Rtf2 PF04641.12 CDI85295.1 - 0.77 9.1 13.3 0.97 8.7 13.3 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger PIP5K PF01504.18 CDI85295.1 - 0.82 8.8 14.6 1 8.5 14.6 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase SLC12 PF03522.15 CDI85295.1 - 0.87 8.5 17.1 0.99 8.4 17.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 AIM3 PF17096.5 CDI85295.1 - 1.3 10.0 15.5 4.6 8.2 4.0 2.1 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 Tub PF01167.18 CDI85295.1 - 1.3 8.7 14.0 1.5 8.5 14.0 1.1 1 0 0 1 1 1 0 Tub family PA26 PF04636.13 CDI85295.1 - 1.4 7.7 14.6 1.6 7.6 14.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF2828 PF11443.8 CDI85295.1 - 1.8 6.6 16.3 2.2 6.3 16.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Otopetrin PF03189.13 CDI85295.1 - 3 6.6 9.7 3.7 6.2 9.7 1.2 1 0 0 1 1 1 0 Otopetrin Hydin_ADK PF17213.3 CDI85295.1 - 3.1 8.0 16.5 4.5 7.5 16.5 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain ALMT PF11744.8 CDI85295.1 - 3.4 6.4 15.6 4 6.2 15.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter IER PF05760.12 CDI85295.1 - 3.5 7.8 22.9 3.7 7.8 22.9 1.1 1 0 0 1 1 1 0 Immediate early response protein (IER) SARAF PF06682.12 CDI85295.1 - 4.9 6.7 17.8 5.8 6.5 17.8 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis CNDH2_N PF06278.11 CDI85295.1 - 5.6 7.2 19.3 3 8.1 4.2 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Conotoxin PF02950.17 CDI85295.1 - 5.9 8.0 13.6 10 7.2 2.4 2.1 2 0 0 2 2 2 0 Conotoxin DUF4175 PF13779.6 CDI85295.1 - 6.1 4.6 36.1 8.4 4.2 36.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TOM13 PF08219.11 CDI85295.1 - 6.8 6.7 10.6 2.4 8.2 2.2 2.2 2 0 0 2 2 2 0 Outer membrane protein TOM13 AUX_IAA PF02309.16 CDI85295.1 - 7.1 6.4 12.1 8.9 6.1 12.1 1.1 1 0 0 1 1 1 0 AUX/IAA family MDM10 PF12519.8 CDI85295.1 - 7.2 5.4 14.6 8.9 5.1 14.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Membralin PF09746.9 CDI85295.1 - 8 5.4 12.9 9.1 5.2 12.9 1.1 1 0 0 1 1 1 0 Tumour-associated protein Serinc PF03348.15 CDI85295.1 - 8.4 5.2 14.0 10 4.9 14.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) MRP-S26 PF14943.6 CDI85295.1 - 8.7 6.2 24.2 12 5.8 24.2 1.1 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 AARP2CN PF08142.12 CDI85295.1 - 9.5 6.4 9.7 1.1 9.4 1.3 2.1 1 1 1 2 2 2 0 AARP2CN (NUC121) domain Dehydrin PF00257.19 CDI85297.1 - 0.0015 19.1 18.9 0.0015 19.1 18.9 8.5 4 2 1 5 5 5 1 Dehydrin DUF202 PF02656.15 CDI85297.1 - 0.49 10.9 3.0 1.2 9.6 0.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF202) GT87 PF09594.10 CDI85297.1 - 4.4 6.9 10.0 0.17 11.6 2.8 2.0 2 0 0 2 2 2 0 Glycosyltransferase family 87 NAD_synthase PF02540.17 CDI85298.1 - 0.00065 18.9 0.1 0.0021 17.2 0.0 1.8 2 0 0 2 2 2 1 NAD synthase TFIIA PF03153.13 CDI85298.1 - 0.0041 17.2 10.0 0.005 16.9 10.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit NBD_C PF17042.5 CDI85298.1 - 0.0055 17.2 8.5 0.0082 16.7 8.5 1.2 1 0 0 1 1 1 1 Nucleotide-binding C-terminal domain Ndc1_Nup PF09531.10 CDI85298.1 - 0.029 13.1 0.8 0.029 13.1 0.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 CDI85298.1 - 0.03 13.1 1.1 0.034 12.9 1.1 1.1 1 0 0 1 1 1 0 Presenilin Activator_LAG-3 PF11498.8 CDI85298.1 - 0.038 13.0 13.3 0.045 12.7 13.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF2722 PF10846.8 CDI85298.1 - 0.041 12.8 9.7 0.051 12.5 9.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI85298.1 - 0.045 13.4 15.4 0.058 13.0 15.4 1.1 1 0 0 1 1 1 0 Spt20 family MPM1 PF17234.2 CDI85298.1 - 0.1 12.8 5.1 0.14 12.4 5.1 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 SpoVR PF04293.13 CDI85298.1 - 0.64 8.6 5.5 0.78 8.4 5.5 1.1 1 0 0 1 1 1 0 SpoVR like protein Isy1 PF06246.12 CDI85298.1 - 0.88 9.1 8.2 1.2 8.7 8.2 1.1 1 0 0 1 1 1 0 Isy1-like splicing family TraV PF09676.10 CDI85298.1 - 1.1 10.2 9.4 1.6 9.7 9.4 1.2 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) RNA_pol_I_A49 PF06870.12 CDI85298.1 - 2.2 7.0 10.1 3 6.6 10.1 1.1 1 0 0 1 1 1 0 A49-like RNA polymerase I associated factor XRN_M PF17846.1 CDI85298.1 - 2.4 7.0 6.2 3.1 6.6 6.2 1.1 1 0 0 1 1 1 0 Xrn1 helical domain DUF3292 PF11696.8 CDI85298.1 - 4.6 5.5 8.0 5.7 5.2 8.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF3347 PF11827.8 CDI85298.1 - 6.4 6.9 13.2 8.7 6.5 13.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Spt20 PF12090.8 CDI85299.1 - 0.017 14.7 25.3 0.017 14.7 25.3 1.0 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI85299.1 - 0.038 14.9 7.5 0.037 15.0 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 CDI85299.1 - 0.11 11.2 4.6 0.1 11.3 4.6 1.0 1 0 0 1 1 1 0 Presenilin ATG22 PF11700.8 CDI85299.1 - 0.18 10.4 0.1 0.19 10.3 0.1 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like TMEM208_SND2 PF05620.11 CDI85299.1 - 0.39 10.5 5.4 0.36 10.6 5.4 1.2 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 Coilin_N PF15862.5 CDI85299.1 - 0.41 10.4 9.4 0.42 10.4 9.4 1.1 1 0 0 1 1 1 0 Coilin N-terminus MPC PF03650.13 CDI85299.1 - 0.43 10.8 4.4 1.4 9.1 4.4 1.8 1 1 0 1 1 1 0 Mitochondrial pyruvate carriers Androgen_recep PF02166.16 CDI85299.1 - 0.76 8.5 24.9 0.72 8.6 24.9 1.0 1 0 0 1 1 1 0 Androgen receptor DUF4407 PF14362.6 CDI85299.1 - 1.2 8.4 7.4 1.1 8.5 7.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) eIF-3_zeta PF05091.12 CDI85299.1 - 2.6 6.9 13.7 2.6 6.9 13.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Herpes_pp85 PF04637.12 CDI85300.1 - 1.2 7.5 12.6 0.41 9.0 4.4 2.1 2 0 0 2 2 2 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) S36_mt PF10937.8 CDI85301.1 - 0.00064 21.3 0.0 0.00064 21.3 0.0 2.4 2 1 1 3 3 2 1 Ribosomal protein S36, mitochondrial TFIIA PF03153.13 CDI85301.1 - 0.0008 19.5 22.8 0.0008 19.5 22.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Miga PF10265.9 CDI85301.1 - 0.017 14.1 1.7 0.021 13.9 1.7 1.0 1 0 0 1 1 1 0 Mitoguardin CSRNP_N PF16019.5 CDI85301.1 - 0.045 13.7 7.6 0.057 13.3 7.6 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Zip PF02535.22 CDI85301.1 - 0.12 11.6 1.3 0.12 11.6 1.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 CDI85301.1 - 0.4 9.4 11.4 0.47 9.1 11.4 1.1 1 0 0 1 1 1 0 Presenilin BBS2_C PF14782.6 CDI85301.1 - 0.42 9.3 7.3 0.54 9.0 7.3 1.0 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal PAT1 PF09770.9 CDI85301.1 - 0.89 7.7 21.3 0.98 7.6 21.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CobT PF06213.12 CDI85301.1 - 1.1 8.6 17.0 1.6 8.1 17.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SLC12 PF03522.15 CDI85301.1 - 1.2 8.1 8.6 1.4 7.9 8.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 GREB1 PF15782.5 CDI85301.1 - 1.4 5.9 10.0 1.6 5.7 10.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ndc1_Nup PF09531.10 CDI85301.1 - 2.1 6.9 9.1 2.1 6.9 9.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CPSF100_C PF13299.6 CDI85301.1 - 2.5 8.3 9.6 3.5 7.8 9.6 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Neur_chan_memb PF02932.16 CDI85301.1 - 2.5 8.1 9.5 3.3 7.7 9.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TERB2 PF15101.6 CDI85301.1 - 2.8 8.0 13.3 4.9 7.2 13.3 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF1387 PF07139.11 CDI85301.1 - 2.8 7.6 13.3 3.7 7.2 13.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) MMR1 PF08505.10 CDI85301.1 - 3.5 7.9 15.0 5.4 7.2 15.0 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Band_3_cyto PF07565.13 CDI85301.1 - 3.5 7.3 10.0 4.6 7.0 10.0 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RR_TM4-6 PF06459.12 CDI85301.1 - 3.7 7.3 11.6 4.9 6.9 11.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4770 PF15994.5 CDI85301.1 - 4.3 7.5 13.0 6.5 7.0 13.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Sec62 PF03839.16 CDI85301.1 - 5.3 6.5 6.1 7 6.1 6.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Suf PF05843.14 CDI85301.1 - 7.7 6.4 16.2 10 6.0 16.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CNDH2_M PF16869.5 CDI85301.1 - 9.4 6.9 13.3 15 6.3 13.3 1.2 1 0 0 1 1 1 0 PF16858 Ribosomal_L11 PF00298.19 CDI85303.1 - 5.6e-22 78.0 0.0 8.7e-22 77.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 CDI85303.1 - 1.3e-08 34.6 0.2 2.5e-08 33.6 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain DUF572 PF04502.13 CDI85304.1 - 2.2e-67 228.0 0.7 3.1e-67 227.6 0.7 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) PI3K_1B_p101 PF10486.9 CDI85304.1 - 0.00016 19.7 11.0 0.0002 19.3 11.0 1.2 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Tox-GHH PF15636.6 CDI85304.1 - 0.52 10.3 3.2 0.22 11.5 0.3 1.9 2 0 0 2 2 2 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin PAP1 PF08601.10 CDI85304.1 - 6 6.5 24.9 9.2 5.9 24.9 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 RTX PF02382.15 CDI85306.1 - 0.06 13.0 14.4 0.081 12.6 14.4 1.1 1 0 0 1 1 1 0 N-terminal domain in RTX protein SID-1_RNA_chan PF13965.6 CDI85306.1 - 0.12 10.7 13.8 0.16 10.4 13.8 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 VIT1 PF01988.19 CDI85306.1 - 0.16 11.8 23.5 0.11 12.4 20.7 1.7 1 1 1 2 2 2 0 VIT family MDM10 PF12519.8 CDI85306.1 - 0.23 10.3 23.8 0.24 10.2 23.8 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 PRP1_N PF06424.12 CDI85306.1 - 0.46 10.9 23.8 0.56 10.6 23.8 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF4231 PF14015.6 CDI85306.1 - 1.1 9.7 10.2 0.037 14.5 3.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) SLC12 PF03522.15 CDI85306.1 - 1.9 7.4 30.3 2.2 7.2 30.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF5065 PF16723.5 CDI85306.1 - 2.6 8.1 14.5 3.6 7.6 14.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5065) RR_TM4-6 PF06459.12 CDI85306.1 - 2.8 7.7 26.6 3.8 7.2 26.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI85306.1 - 2.9 6.6 36.4 3.4 6.3 36.4 1.1 1 0 0 1 1 1 0 Presenilin CD20 PF04103.15 CDI85306.1 - 4.7 7.3 23.4 4.6e+03 -2.4 23.4 2.4 1 1 0 1 1 1 0 CD20-like family PAT1 PF09770.9 CDI85306.1 - 5.7 5.1 51.8 6.5 4.9 51.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GAGA_bind PF06217.12 CDI85306.1 - 6.6 6.9 26.0 7.6 6.7 26.0 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family HCO3_cotransp PF00955.21 CDI85306.1 - 7 5.4 13.1 8.9 5.0 13.1 1.3 1 0 0 1 1 1 0 HCO3- transporter family ALMT PF11744.8 CDI85306.1 - 9.5 4.9 25.2 13 4.5 25.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter RIFIN PF02009.16 CDI85306.1 - 10 5.9 25.7 11 5.9 25.7 1.0 1 0 0 1 1 1 0 Rifin TFIIA PF03153.13 CDI85307.1 - 2.1 8.2 74.6 2.7 7.9 74.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDK5_activator PF03261.15 CDI85308.1 - 0.039 13.5 20.3 0.051 13.1 20.3 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein AAA_23 PF13476.6 CDI85308.1 - 0.15 12.5 16.3 0.2 12.2 16.3 1.2 1 0 0 1 1 1 0 AAA domain PPP4R2 PF09184.11 CDI85308.1 - 0.5 9.9 15.9 0.56 9.8 15.9 1.2 1 0 0 1 1 1 0 PPP4R2 DDRGK PF09756.9 CDI85308.1 - 1.3 8.6 22.0 0.58 9.7 17.1 2.1 2 0 0 2 2 2 0 DDRGK domain TFIIA PF03153.13 CDI85308.1 - 1.5 8.7 59.2 2 8.3 59.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LMBR1 PF04791.16 CDI85308.1 - 4.4 6.1 14.8 4.6 6.0 14.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DHquinase_II PF01220.19 CDI85308.1 - 4.5 6.9 9.8 0.79 9.4 5.7 1.8 2 0 0 2 2 2 0 Dehydroquinase class II DUF4551 PF15087.6 CDI85308.1 - 5.7 5.7 28.1 6.6 5.4 28.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Dicty_REP PF05086.12 CDI85308.1 - 6.2 4.7 18.3 7.1 4.5 18.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SR-25 PF10500.9 CDI85308.1 - 7.1 6.2 50.1 0.055 13.1 37.7 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 CDI85309.1 - 8.9 5.0 47.9 11 4.7 47.9 1.0 1 0 0 1 1 1 0 Presenilin Herpes_pp85 PF04637.12 CDI85310.1 - 2 6.8 7.0 3.9 5.8 7.0 1.5 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) LZ_Tnp_IS66 PF13007.7 CDI85310.1 - 8.2 7.3 10.1 12 6.7 2.0 3.2 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain Kazal_2 PF07648.15 CDI85311.1 - 3.2e-17 62.4 23.7 2.1e-11 43.8 3.3 4.2 3 1 0 3 3 3 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 CDI85311.1 - 3.6e-15 55.7 17.2 4.2e-10 39.5 4.8 3.6 3 0 0 3 3 3 2 Kazal-type serine protease inhibitor domain DUF3446 PF11928.8 CDI85311.1 - 1.2 9.5 19.2 0.15 12.4 6.7 3.6 3 0 0 3 3 3 0 Early growth response N-terminal domain Synaptobrevin PF00957.21 CDI85313.1 - 4.7e-24 84.0 1.0 8.5e-24 83.2 1.0 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CDI85313.1 - 1.2e-19 70.1 0.0 2.7e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF3290 PF11694.8 CDI85313.1 - 0.027 14.4 0.2 0.046 13.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) Herpes_teg_N PF04843.12 CDI85313.1 - 0.049 13.3 0.0 0.088 12.5 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus tegument protein, N-terminal conserved region RskA PF10099.9 CDI85315.1 - 0.042 14.2 21.6 0.11 12.7 11.4 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA ADP_ribosyl_GH PF03747.14 CDI85315.1 - 0.16 11.7 20.4 0.47 10.1 7.1 2.0 1 1 1 2 2 2 0 ADP-ribosylglycohydrolase GHMP_kinases_N PF00288.26 CDI85315.1 - 1.1 9.5 14.3 0.84 9.9 0.7 2.5 2 1 0 2 2 2 0 GHMP kinases N terminal domain SWI-SNF_Ssr4 PF08549.10 CDI85315.1 - 4 6.0 13.7 4.8 5.7 13.7 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) ASFV_J13L PF05568.11 CDI85315.1 - 8.1 6.2 9.5 9.1 6.0 2.9 2.2 2 0 0 2 2 2 0 African swine fever virus J13L protein DcuA_DcuB PF03605.14 CDI85316.1 - 0.00053 19.0 8.7 0.00063 18.7 8.7 1.0 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter CD20 PF04103.15 CDI85316.1 - 0.00081 19.5 0.2 0.00098 19.2 0.2 1.1 1 0 0 1 1 1 1 CD20-like family ArsP_1 PF03773.13 CDI85316.1 - 0.0034 16.6 0.7 0.0039 16.4 0.7 1.0 1 0 0 1 1 1 1 Predicted permease NicO PF03824.16 CDI85316.1 - 0.0055 16.1 3.0 0.0062 15.9 3.0 1.0 1 0 0 1 1 1 1 High-affinity nickel-transport protein FHIPEP PF00771.20 CDI85316.1 - 0.0056 15.2 10.0 0.0062 15.1 10.0 1.0 1 0 0 1 1 1 1 FHIPEP family VIT1 PF01988.19 CDI85316.1 - 0.01 15.7 7.1 0.013 15.4 7.1 1.1 1 0 0 1 1 1 0 VIT family Connexin PF00029.19 CDI85316.1 - 0.019 14.7 5.8 0.021 14.6 5.8 1.1 1 0 0 1 1 1 0 Connexin Trp_oprn_chp PF09534.10 CDI85316.1 - 0.023 14.5 14.6 0.028 14.2 14.6 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF719 PF05334.13 CDI85316.1 - 0.026 14.7 13.7 0.031 14.5 13.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF719) RskA PF10099.9 CDI85316.1 - 0.029 14.7 30.4 0.045 14.0 30.4 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA FAM199X PF15814.5 CDI85316.1 - 0.029 13.4 10.4 0.032 13.3 10.4 1.0 1 0 0 1 1 1 0 Protein family FAM199X PAP2_3 PF14378.6 CDI85316.1 - 0.032 13.9 3.2 0.043 13.5 3.2 1.2 1 0 0 1 1 1 0 PAP2 superfamily OATP PF03137.20 CDI85316.1 - 0.034 12.4 5.1 0.035 12.4 5.1 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family TFB6 PF17110.5 CDI85316.1 - 0.042 13.6 3.4 0.048 13.4 3.4 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF2232 PF09991.9 CDI85316.1 - 0.052 12.7 9.2 0.059 12.6 9.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Peptidase_S49_N PF08496.10 CDI85316.1 - 0.053 13.6 7.9 0.063 13.3 7.9 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal TERB2 PF15101.6 CDI85316.1 - 0.058 13.5 16.1 0.068 13.2 16.1 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 MecA PF05389.12 CDI85316.1 - 0.061 12.9 7.5 0.067 12.8 7.5 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) FPN1 PF06963.12 CDI85316.1 - 0.072 11.6 6.0 0.089 11.3 6.0 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Serinc PF03348.15 CDI85316.1 - 0.072 12.0 11.8 0.078 11.9 11.8 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) TMEM174 PF15029.6 CDI85316.1 - 0.074 12.8 11.1 0.084 12.6 11.1 1.0 1 0 0 1 1 1 0 Transmembrane protein 174 Pex26 PF07163.12 CDI85316.1 - 0.077 12.3 10.7 0.079 12.2 10.7 1.2 1 0 0 1 1 1 0 Pex26 protein EPL1 PF10513.9 CDI85316.1 - 0.085 13.2 10.5 0.1 13.0 10.5 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Bud13 PF09736.9 CDI85316.1 - 0.085 13.3 14.0 0.1 13.0 14.0 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex SID-1_RNA_chan PF13965.6 CDI85316.1 - 0.086 11.2 6.1 0.097 11.1 6.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI85316.1 - 0.088 10.7 11.0 0.089 10.7 11.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TFIIA PF03153.13 CDI85316.1 - 0.091 12.7 40.0 0.11 12.5 40.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SLATT_1 PF18181.1 CDI85316.1 - 0.092 12.7 17.3 0.12 12.3 17.3 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 Ctr PF04145.15 CDI85316.1 - 0.098 13.3 4.2 0.12 13.0 4.2 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Activator_LAG-3 PF11498.8 CDI85316.1 - 0.1 11.5 38.0 0.12 11.4 38.0 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 eIF-3_zeta PF05091.12 CDI85316.1 - 0.12 11.4 16.5 0.13 11.2 16.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CLN3 PF02487.17 CDI85316.1 - 0.14 11.2 8.2 0.16 11.0 8.2 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4820 PF16091.5 CDI85316.1 - 0.14 11.5 11.3 0.17 11.2 11.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Tim54 PF11711.8 CDI85316.1 - 0.16 10.7 9.6 0.18 10.5 9.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2298 PF10060.9 CDI85316.1 - 0.16 10.6 6.0 0.18 10.5 6.0 1.0 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) SpoIIP PF07454.11 CDI85316.1 - 0.16 11.4 12.3 0.18 11.2 12.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FAM60A PF15396.6 CDI85316.1 - 0.19 11.7 8.7 0.2 11.6 8.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF2207 PF09972.9 CDI85316.1 - 0.2 10.4 4.1 0.2 10.4 4.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1980 PF09323.10 CDI85316.1 - 0.22 11.4 8.9 0.23 11.3 8.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) HemX PF04375.14 CDI85316.1 - 0.22 10.8 28.6 0.25 10.6 28.6 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Bac_luciferase PF00296.20 CDI85316.1 - 0.23 10.8 11.9 0.29 10.5 11.9 1.1 1 0 0 1 1 1 0 Luciferase-like monooxygenase PIP5K PF01504.18 CDI85316.1 - 0.24 10.6 6.7 0.24 10.6 6.7 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2828 PF11443.8 CDI85316.1 - 0.25 9.4 11.7 0.29 9.2 11.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SMYLE_N PF18615.1 CDI85316.1 - 0.26 10.8 13.5 0.29 10.7 13.5 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain RPOL_N PF14700.6 CDI85316.1 - 0.29 10.5 17.8 0.36 10.2 17.8 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal DDHD PF02862.17 CDI85316.1 - 0.31 11.2 14.8 0.36 10.9 14.8 1.1 1 0 0 1 1 1 0 DDHD domain Suf PF05843.14 CDI85316.1 - 0.32 11.0 19.8 0.37 10.7 19.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 CDI85316.1 - 0.33 11.0 8.4 0.36 10.9 8.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SelP_N PF04592.14 CDI85316.1 - 0.34 10.3 13.9 0.38 10.1 13.9 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Exonuc_VII_L PF02601.15 CDI85316.1 - 0.36 10.4 15.6 0.42 10.1 15.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit ADP_ribosyl_GH PF03747.14 CDI85316.1 - 0.38 10.4 12.2 0.44 10.2 12.2 1.0 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase OmpH PF03938.14 CDI85316.1 - 0.43 10.9 31.1 0.54 10.6 31.1 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) UPF0560 PF10577.9 CDI85316.1 - 0.51 8.8 19.4 0.56 8.6 19.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 AF-4 PF05110.13 CDI85316.1 - 0.55 8.3 16.8 0.61 8.1 16.8 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Med15 PF09606.10 CDI85316.1 - 0.57 8.8 31.1 0.89 8.2 31.1 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal 2HCT PF03390.15 CDI85316.1 - 0.57 8.7 5.8 0.65 8.5 5.8 1.1 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family DivIC PF04977.15 CDI85316.1 - 0.58 10.0 20.3 0.95 9.3 20.3 1.3 1 0 0 1 1 1 0 Septum formation initiator O-antigen_lig PF13425.6 CDI85316.1 - 0.6 8.8 3.7 0.68 8.7 3.7 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4569 PF15133.6 CDI85316.1 - 0.67 9.6 14.3 0.77 9.4 14.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) EMC3_TMCO1 PF01956.16 CDI85316.1 - 0.76 9.5 9.0 0.85 9.3 9.0 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF726 PF05277.12 CDI85316.1 - 0.79 8.6 6.2 0.87 8.4 6.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DUF4228 PF14009.6 CDI85316.1 - 0.84 10.0 7.4 1 9.7 7.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Sec62 PF03839.16 CDI85316.1 - 0.87 9.1 9.5 1 8.9 9.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4770 PF15994.5 CDI85316.1 - 0.87 9.8 13.7 1.2 9.4 13.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) IHABP4_N PF16174.5 CDI85316.1 - 0.92 10.1 18.0 1.2 9.7 18.0 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal DUF913 PF06025.12 CDI85316.1 - 0.94 8.4 9.6 1.1 8.2 9.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hamartin PF04388.12 CDI85316.1 - 0.98 8.0 14.6 1 7.9 14.6 1.0 1 0 0 1 1 1 0 Hamartin protein XRN_M PF17846.1 CDI85316.1 - 1 8.3 11.6 1.2 8.0 11.6 1.0 1 0 0 1 1 1 0 Xrn1 helical domain RR_TM4-6 PF06459.12 CDI85316.1 - 1 9.1 15.7 1.2 8.9 15.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CSG2 PF16965.5 CDI85316.1 - 1.1 8.1 6.6 1.2 8.0 6.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator NEMP PF10225.9 CDI85316.1 - 1.2 8.7 6.7 1.4 8.5 6.7 1.0 1 0 0 1 1 1 0 NEMP family Gti1_Pac2 PF09729.9 CDI85316.1 - 1.4 9.0 9.4 1.7 8.7 9.4 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Endostatin PF06482.11 CDI85316.1 - 1.4 8.3 14.3 1.4 8.3 14.3 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Baculo_PP31 PF05311.11 CDI85316.1 - 1.4 8.3 13.8 1.7 8.1 13.8 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) TCP PF03634.13 CDI85316.1 - 1.4 9.4 17.9 1.8 9.1 17.9 1.1 1 0 0 1 1 1 0 TCP family transcription factor EphA2_TM PF14575.6 CDI85316.1 - 1.5 9.8 9.7 3.9 8.4 9.7 1.8 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain AAA_23 PF13476.6 CDI85316.1 - 1.5 9.3 12.7 1.5 9.2 12.7 1.1 1 0 0 1 1 1 0 AAA domain Glt_symporter PF03616.14 CDI85316.1 - 1.6 7.3 7.0 1.9 7.1 7.0 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter CNDH2_M PF16869.5 CDI85316.1 - 1.7 9.3 10.7 2.7 8.7 10.7 1.3 1 0 0 1 1 1 0 PF16858 CDC27 PF09507.10 CDI85316.1 - 1.9 7.8 19.1 2.1 7.6 19.1 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 R_equi_Vir PF05526.11 CDI85316.1 - 2.1 8.2 16.3 3.1 7.6 16.3 1.3 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Radical_SAM_N PF08497.10 CDI85316.1 - 2.2 7.5 10.5 2.4 7.3 10.5 1.0 1 0 0 1 1 1 0 Radical SAM N-terminal Hydin_ADK PF17213.3 CDI85316.1 - 2.3 8.5 17.8 2.8 8.2 17.8 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain EOS1 PF12326.8 CDI85316.1 - 2.3 8.1 10.4 2.9 7.8 10.4 1.1 1 0 0 1 1 1 0 N-glycosylation protein Ndc1_Nup PF09531.10 CDI85316.1 - 2.3 6.8 17.1 2.7 6.6 17.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 CDI85316.1 - 2.4 6.3 26.8 2.6 6.2 26.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EIF4E-T PF10477.9 CDI85316.1 - 2.4 6.9 20.4 2.5 6.8 20.4 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E YjbH PF06082.11 CDI85316.1 - 2.5 6.8 14.7 2.9 6.6 14.7 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH SLC12 PF03522.15 CDI85316.1 - 2.7 6.9 14.3 3 6.8 14.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF572 PF04502.13 CDI85316.1 - 3.5 7.2 15.5 4.1 6.9 15.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SSP160 PF06933.11 CDI85316.1 - 3.7 5.6 22.6 4 5.5 22.6 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FixO PF02433.15 CDI85316.1 - 4 6.8 11.4 4.8 6.6 11.4 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO ALMT PF11744.8 CDI85316.1 - 4.3 6.1 11.0 4.7 5.9 11.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Endomucin PF07010.12 CDI85316.1 - 4.3 7.2 20.5 4.7 7.1 20.5 1.0 1 0 0 1 1 1 0 Endomucin Band_3_cyto PF07565.13 CDI85316.1 - 4.4 7.0 13.3 5.1 6.8 13.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF5521 PF17659.1 CDI85316.1 - 4.7 4.9 13.8 5.2 4.8 13.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5521) DUF1387 PF07139.11 CDI85316.1 - 5.2 6.7 15.8 5.9 6.5 15.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Paramyxo_ncap PF00973.19 CDI85316.1 - 5.4 5.8 13.6 6.5 5.6 13.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Peptidase_S15 PF02129.18 CDI85316.1 - 5.7 6.5 14.7 6.9 6.2 14.7 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Rtf2 PF04641.12 CDI85316.1 - 5.7 6.2 14.4 7 5.9 14.4 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Velvet PF11754.8 CDI85316.1 - 6.5 6.6 18.8 7.5 6.4 18.8 1.0 1 0 0 1 1 1 0 Velvet factor CBP_BcsG PF11658.8 CDI85316.1 - 7.3 4.9 15.2 8.6 4.6 15.2 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Smg8_Smg9 PF10220.9 CDI85316.1 - 7.4 4.7 16.3 8.4 4.6 16.3 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Presenilin PF01080.17 CDI85316.1 - 7.6 5.2 22.3 8.9 5.0 22.3 1.0 1 0 0 1 1 1 0 Presenilin DUF4667 PF15700.5 CDI85316.1 - 8.1 6.5 20.7 10 6.2 20.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) BAF1_ABF1 PF04684.13 CDI85316.1 - 9.6 5.1 20.8 12 4.8 20.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SprA-related PF12118.8 CDI85316.1 - 9.9 5.2 39.1 16 4.5 39.1 1.2 1 0 0 1 1 1 0 SprA-related family MMR1 PF08505.10 CDI85316.1 - 9.9 6.4 23.8 11 6.2 23.8 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SR-25 PF10500.9 CDI85318.1 - 4.6e-05 23.1 9.9 4.6e-05 23.1 9.9 9.9 4 2 5 9 9 9 1 Nuclear RNA-splicing-associated protein AAA PF00004.29 CDI85319.1 - 5.1e-17 62.5 1.3 1.5e-16 61.0 0.0 2.6 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 CDI85319.1 - 2.2e-15 57.1 1.1 2.2e-15 57.1 1.1 3.5 3 1 0 3 3 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 CDI85319.1 - 1.3e-06 28.5 0.0 3.5e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Lon_C PF05362.13 CDI85319.1 - 2e-06 27.5 0.3 5.7e-06 26.0 0.0 1.9 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain AAA_PrkA PF08298.11 CDI85319.1 - 4.5e-06 25.8 0.0 7.7e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_16 PF13191.6 CDI85319.1 - 0.00011 22.7 0.1 0.00011 22.7 0.1 4.9 4 3 0 4 4 1 1 AAA ATPase domain IstB_IS21 PF01695.17 CDI85319.1 - 0.00033 20.4 0.0 0.0015 18.3 0.0 2.1 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 CDI85319.1 - 0.00043 20.6 2.0 0.006 16.9 0.1 3.6 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 CDI85319.1 - 0.00051 19.8 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain PAP1 PF08601.10 CDI85319.1 - 0.0042 16.9 0.0 0.0042 16.9 0.0 4.2 2 2 2 4 4 1 1 Transcription factor PAP1 PNISR PF15996.5 CDI85319.1 - 0.0066 16.8 33.7 0.0066 16.8 33.7 4.8 3 2 2 5 5 1 1 Arginine/serine-rich protein PNISR RNA_helicase PF00910.22 CDI85319.1 - 0.03 14.7 0.0 0.12 12.7 0.0 2.1 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 CDI85319.1 - 0.065 13.8 0.0 0.065 13.8 0.0 3.3 3 1 1 4 4 3 0 AAA domain RsgA_GTPase PF03193.16 CDI85319.1 - 0.066 13.1 0.0 0.066 13.1 0.0 3.2 4 0 0 4 4 3 0 RsgA GTPase AAA_17 PF13207.6 CDI85319.1 - 0.21 12.0 0.0 0.21 12.0 0.0 4.3 4 1 1 5 5 2 0 AAA domain SPX PF03105.19 CDI85319.1 - 2.6 7.9 69.1 0.12 12.3 23.4 3.5 2 1 1 3 3 2 0 SPX domain BSP_II PF05432.11 CDI85319.1 - 4 7.1 35.1 2.3 7.8 26.2 2.5 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Lon_C PF05362.13 CDI85320.1 - 8.4e-23 81.0 0.1 1.1e-22 80.6 0.1 1.2 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain ChlI PF13541.6 CDI85320.1 - 0.00019 21.2 0.1 0.00033 20.5 0.1 1.4 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase PP-binding_2 PF14573.6 CDI85320.1 - 0.19 12.0 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 Acyl-carrier Herpes_LMP1 PF05297.11 CDI85320.1 - 1.2 8.3 6.9 1.5 7.9 6.9 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Dehydrin PF00257.19 CDI85321.1 - 6 7.4 15.4 7.4 7.1 15.4 1.1 1 0 0 1 1 1 0 Dehydrin FSA_C PF10479.9 CDI85322.1 - 0.88 7.6 8.3 1.4 7.0 8.3 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF1645 PF07816.11 CDI85323.1 - 1.6e-06 28.9 1.6 1.6e-06 28.9 1.6 2.6 2 1 0 2 2 1 1 Protein of unknown function (DUF1645) Chorion_2 PF03964.15 CDI85323.1 - 0.0059 17.4 4.2 0.0059 17.4 4.2 5.9 5 1 1 6 6 3 1 Chorion family 2 SR-25 PF10500.9 CDI85323.1 - 0.0093 15.6 4.5 0.0093 15.6 4.5 3.4 3 1 0 3 3 2 1 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI85323.1 - 0.0096 16.2 15.8 0.0096 16.2 15.8 3.9 3 2 0 3 3 3 2 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI85323.1 - 0.01 15.5 13.9 0.01 15.5 13.9 3.3 2 1 0 2 2 1 0 Spt20 family IMUP PF15761.5 CDI85323.1 - 0.032 14.9 6.2 0.032 14.9 6.2 3.6 4 0 0 4 4 3 0 Immortalisation up-regulated protein Rgp1 PF08737.10 CDI85323.1 - 0.064 12.4 12.7 0.027 13.7 2.4 2.3 2 0 0 2 2 2 0 Rgp1 FCP1_C PF09309.10 CDI85323.1 - 0.083 12.8 14.7 0.037 13.9 4.4 2.4 2 0 0 2 2 2 0 FCP1, C-terminal Miga PF10265.9 CDI85323.1 - 0.91 8.4 26.8 0.39 9.6 11.6 2.1 2 0 0 2 2 2 0 Mitoguardin DUF1635 PF07795.11 CDI85323.1 - 1.9 8.3 30.2 0.23 11.3 8.6 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1635) RR_TM4-6 PF06459.12 CDI85323.1 - 2.3 8.0 8.7 1.8 8.3 1.2 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF4667 PF15700.5 CDI85323.1 - 2.3 8.3 28.3 0.73 9.9 9.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4667) Fmp27_WPPW PF10359.9 CDI85323.1 - 4.8 5.9 16.2 1.8 7.3 5.3 2.2 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Peptidase_S64 PF08192.11 CDI85323.1 - 9.8 4.5 18.0 0.21 10.1 3.7 2.1 2 0 0 2 2 2 0 Peptidase family S64 Pex14_N PF04695.13 CDI85324.1 - 0.0069 17.1 39.6 0.0069 17.1 39.6 3.3 2 1 0 2 2 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PTPRCAP PF15713.5 CDI85324.1 - 0.022 15.0 33.8 0.2 11.9 26.5 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated RPOL_N PF14700.6 CDI85324.1 - 0.026 13.9 39.7 0.048 13.0 24.8 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal Presenilin PF01080.17 CDI85324.1 - 0.028 13.2 54.2 0.039 12.7 31.5 2.1 2 0 0 2 2 2 0 Presenilin DUF5523 PF17661.1 CDI85324.1 - 0.043 13.5 30.8 0.06 13.0 19.7 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) FAM60A PF15396.6 CDI85324.1 - 0.064 13.3 36.5 0.22 11.5 5.1 2.2 2 0 0 2 2 2 0 Protein Family FAM60A CLN3 PF02487.17 CDI85324.1 - 0.078 12.0 28.2 0.094 11.7 15.9 2.2 2 0 0 2 2 2 0 CLN3 protein PPL5 PF18168.1 CDI85324.1 - 0.096 12.0 25.5 0.076 12.3 13.9 2.4 2 0 0 2 2 2 0 Prim-pol family 5 CNDH2_C PF16858.5 CDI85324.1 - 0.15 11.9 31.9 0.86 9.4 22.9 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Trp_oprn_chp PF09534.10 CDI85324.1 - 0.28 11.0 29.1 0.16 11.8 8.3 3.2 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PBP1_TM PF14812.6 CDI85324.1 - 0.39 11.1 13.6 9.7 6.6 12.0 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Vfa1 PF08432.10 CDI85324.1 - 0.43 10.9 39.4 0.26 11.6 24.1 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 SLC12 PF03522.15 CDI85324.1 - 0.48 9.4 46.6 0.2 10.6 26.5 2.0 2 0 0 2 2 2 0 Solute carrier family 12 BAF1_ABF1 PF04684.13 CDI85324.1 - 0.55 9.2 61.3 0.59 9.1 29.5 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor BORG_CEP PF14957.6 CDI85324.1 - 0.76 11.0 32.6 2.7 9.2 18.1 2.2 2 0 0 2 2 2 0 Cdc42 effector RR_TM4-6 PF06459.12 CDI85324.1 - 0.93 9.3 47.9 1 9.2 30.9 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 CDI85324.1 - 1.2 7.4 35.2 1.1 7.5 25.2 2.1 2 0 0 2 2 2 0 CDC45-like protein FAM76 PF16046.5 CDI85324.1 - 1.3 8.3 38.3 1.2 8.4 3.4 2.3 2 0 0 2 2 2 0 FAM76 protein DUF3295 PF11702.8 CDI85324.1 - 1.5 8.1 47.4 1.9 7.7 26.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) CBP_BcsG PF11658.8 CDI85324.1 - 1.5 7.1 32.9 0.032 12.6 16.2 2.2 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG DUF3807 PF12720.7 CDI85324.1 - 1.8 8.8 55.9 1.1 9.5 35.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) SDA1 PF05285.12 CDI85324.1 - 2.2 7.6 31.3 3.7 6.9 30.5 1.6 1 1 0 1 1 1 0 SDA1 Macoilin PF09726.9 CDI85324.1 - 2.3 6.7 49.2 3.2 6.2 49.2 1.2 1 0 0 1 1 1 0 Macoilin family Endostatin PF06482.11 CDI85324.1 - 2.5 7.5 38.7 0.32 10.4 23.0 2.3 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Pox_Ag35 PF03286.14 CDI85324.1 - 2.5 7.8 35.0 0.36 10.6 9.3 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein eIF-3_zeta PF05091.12 CDI85324.1 - 4.8 6.1 52.1 4.2 6.2 7.5 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Plasmodium_Vir PF05795.11 CDI85324.1 - 4.8 6.5 37.2 2.6 7.4 13.4 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein O-antigen_lig PF13425.6 CDI85324.1 - 4.8 5.8 23.8 2.4 6.8 12.3 2.2 2 0 0 2 2 2 0 O-antigen ligase like membrane protein SAPS PF04499.15 CDI85324.1 - 5.5 5.7 38.5 0.88 8.3 19.2 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein TT_ORF1 PF02956.14 CDI85324.1 - 7.5 5.1 37.5 2.5 6.7 17.8 2.1 2 0 0 2 2 2 0 TT viral orf 1 PAP1 PF08601.10 CDI85324.1 - 9 5.9 59.4 2.6 7.7 31.2 2.1 2 0 0 2 2 2 0 Transcription factor PAP1 DUF4834 PF16118.5 CDI85325.1 - 0.18 12.8 6.7 0.99 10.4 2.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Orf78 PF06024.12 CDI85325.1 - 0.24 11.7 2.1 1.3 9.3 0.8 2.8 2 0 0 2 2 2 0 Orf78 (ac78) SPX PF03105.19 CDI85325.1 - 0.28 11.0 12.8 0.029 14.3 5.1 2.5 2 1 0 2 2 2 0 SPX domain Rxt3 PF08642.10 CDI85325.1 - 0.39 11.5 2.7 17 6.2 0.2 3.6 3 1 1 4 4 4 0 Histone deacetylation protein Rxt3 E7 PF00527.18 CDI85325.1 - 0.46 10.7 7.0 4.9 7.4 0.9 3.2 2 0 0 2 2 2 0 E7 protein, Early protein Cas1_AcylT PF07779.12 CDI85325.1 - 1.2 7.9 5.4 0.31 9.9 1.2 2.1 2 0 0 2 2 2 0 10 TM Acyl Transferase domain found in Cas1p EphA2_TM PF14575.6 CDI85325.1 - 2.1 9.3 5.9 11 7.0 1.0 4.0 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain UPF0239 PF06783.11 CDI85325.1 - 2.7 8.2 5.3 35 4.7 0.0 3.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0239) SR-25 PF10500.9 CDI85326.1 - 0.61 9.7 8.3 0.91 9.1 8.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAM199X PF15814.5 CDI85326.1 - 2.4 7.1 14.9 0.092 11.8 7.2 2.2 2 0 0 2 2 2 0 Protein family FAM199X SUIM_assoc PF16619.5 CDI85327.1 - 0.0032 17.5 1.9 0.0032 17.5 1.9 6.2 5 1 1 6 6 6 2 Unstructured region C-term to UIM in Ataxin3 CCSAP PF15748.5 CDI85327.1 - 4 7.5 30.9 2.2 8.4 1.4 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Gti1_Pac2 PF09729.9 CDI85329.1 - 0.4 10.8 17.2 0.4 10.7 17.2 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family CobT PF06213.12 CDI85329.1 - 0.78 9.1 26.5 0.97 8.8 26.5 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PIP5K PF01504.18 CDI85329.1 - 1.3 8.2 16.2 1.4 8.1 16.2 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase SARAF PF06682.12 CDI85329.1 - 3.4 7.2 20.7 3.6 7.1 20.7 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis CLN3 PF02487.17 CDI85329.1 - 3.5 6.6 17.0 3.5 6.6 17.0 1.0 1 0 0 1 1 1 0 CLN3 protein SLC12 PF03522.15 CDI85329.1 - 5.1 6.0 20.8 5.3 6.0 20.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Sec62 PF03839.16 CDI85329.1 - 5.2 6.5 17.8 5.8 6.4 17.8 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 CDI85329.1 - 7.8 5.1 25.9 8.3 5.1 25.9 1.0 1 0 0 1 1 1 0 Presenilin SprA-related PF12118.8 CDI85330.1 - 0.0017 17.6 28.4 0.0017 17.6 28.4 2.1 2 0 0 2 2 1 1 SprA-related family RR_TM4-6 PF06459.12 CDI85330.1 - 0.0077 16.1 26.7 0.0097 15.8 26.7 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI85330.1 - 0.035 12.4 39.9 0.041 12.2 39.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SART-1 PF03343.13 CDI85330.1 - 0.039 12.5 26.1 0.056 12.0 26.1 1.2 1 0 0 1 1 1 0 SART-1 family DUF3824 PF12868.7 CDI85330.1 - 0.042 14.5 9.2 0.042 14.5 9.2 3.2 3 0 0 3 3 2 0 Domain of unknwon function (DUF3824) Sulf_transp PF04143.14 CDI85330.1 - 0.15 11.6 5.0 0.054 13.1 2.8 1.3 1 1 0 1 1 1 0 Sulphur transport TMEM220 PF15071.6 CDI85330.1 - 0.22 12.3 0.5 0.54 11.0 0.5 1.8 1 1 0 1 1 1 0 Transmembrane family 220, helix ALMT PF11744.8 CDI85330.1 - 0.31 9.8 16.8 0.36 9.6 16.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 CDI85330.1 - 1.1 8.2 27.2 1.5 7.8 27.2 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI85330.1 - 3.1 5.8 25.9 3.4 5.7 25.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Smg8_Smg9 PF10220.9 CDI85330.1 - 7.1 4.8 27.9 10 4.3 27.9 1.1 1 0 0 1 1 1 0 Smg8_Smg9 CDK5_activator PF03261.15 CDI85330.1 - 7.2 6.1 20.2 9.8 5.6 20.2 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein NnrU PF07298.11 CDI85330.1 - 9.2 5.7 6.7 0.4 10.1 0.3 1.9 2 0 0 2 2 2 0 NnrU protein DUF3464 PF11947.8 CDI85330.1 - 9.7 5.9 30.9 1 9.1 5.1 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Utp14 PF04615.13 CDI85331.1 - 7.2 5.1 42.6 8.8 4.8 42.6 1.2 1 0 0 1 1 1 0 Utp14 protein SARAF PF06682.12 CDI85333.1 - 0.42 10.2 21.5 0.53 9.9 21.5 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF572 PF04502.13 CDI85333.1 - 4.1 6.9 34.3 4.7 6.7 34.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) BPL_N PF09825.9 CDI85333.1 - 7.6 5.5 19.0 9.4 5.2 19.0 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF3915 PF13054.6 CDI85334.1 - 0.22 11.5 2.8 0.31 11.0 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF2057 PF09829.9 CDI85334.1 - 6.8 6.8 16.1 1.5 9.0 3.7 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) SR-25 PF10500.9 CDI85335.1 - 4.9 6.7 19.8 8.7 5.9 19.4 1.7 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4834 PF16118.5 CDI85336.1 - 0.012 16.6 0.1 0.012 16.6 0.1 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) PAP1 PF08601.10 CDI85336.1 - 0.033 13.9 19.0 0.08 12.7 19.1 1.7 1 1 0 1 1 1 0 Transcription factor PAP1 Spt20 PF12090.8 CDI85336.1 - 0.045 13.4 30.6 0.018 14.7 10.5 2.2 2 0 0 2 2 2 0 Spt20 family MAP17 PF15807.5 CDI85336.1 - 0.096 12.9 0.3 0.096 12.9 0.3 2.8 2 1 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 ABC2_membrane_2 PF12679.7 CDI85336.1 - 0.11 11.7 3.7 2.4 7.4 3.7 2.4 1 1 0 1 1 1 0 ABC-2 family transporter protein TSP9 PF11493.8 CDI85336.1 - 0.48 11.1 0.0 0.48 11.1 0.0 4.1 2 1 2 4 4 4 0 Thylakoid soluble phosphoprotein TSP9 DUF4820 PF16091.5 CDI85336.1 - 2.8 7.3 20.9 0.14 11.5 2.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) FTZ PF03867.14 CDI85336.1 - 3.2 7.2 25.2 3.9 6.9 14.5 2.3 2 0 0 2 2 2 0 Fushi tarazu (FTZ), N-terminal region RskA PF10099.9 CDI85339.1 - 0.055 13.8 24.6 0.24 11.7 24.6 1.9 1 1 0 1 1 1 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI85339.1 - 0.08 12.9 25.1 0.1 12.6 25.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Mitofilin PF09731.9 CDI85339.1 - 0.86 8.4 17.8 1.1 8.0 17.8 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein BAF1_ABF1 PF04684.13 CDI85339.1 - 5.9 5.8 17.0 8 5.4 17.0 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FAM176 PF14851.6 CDI85340.1 - 0.0094 15.6 1.9 0.1 12.3 0.1 2.7 3 0 0 3 3 3 1 FAM176 family PEX11 PF05648.14 CDI85340.1 - 0.027 13.9 0.4 0.07 12.6 0.4 1.6 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) POPLD PF08170.12 CDI85340.1 - 0.089 13.2 5.4 0.29 11.5 5.4 1.9 1 0 0 1 1 1 0 POPLD (NUC188) domain OATP PF03137.20 CDI85340.1 - 0.24 9.7 4.4 0.25 9.6 1.3 2.2 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family SPX PF03105.19 CDI85340.1 - 0.89 9.4 16.5 3.4 7.5 16.5 1.7 1 1 0 1 1 1 0 SPX domain Secretin_N_2 PF07655.13 CDI85340.1 - 2.4 8.8 17.2 0.36 11.4 9.1 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain V_ATPase_I PF01496.19 CDI85340.1 - 2.7 5.8 6.2 5 4.9 6.2 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peroxin-13_N PF04088.13 CDI85340.1 - 2.8 8.2 5.0 1.2 9.4 1.1 2.3 3 0 0 3 3 3 0 Peroxin 13, N-terminal region Herpes_pp85 PF04637.12 CDI85340.1 - 3.4 6.0 5.6 7.4 4.9 5.6 1.5 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF1980 PF09323.10 CDI85340.1 - 3.6 7.5 10.1 0.96 9.3 3.5 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1980) CNDH2_M PF16869.5 CDI85340.1 - 9 7.0 12.5 2.6 8.7 5.1 2.6 2 1 0 2 2 2 0 PF16858 EXOSC1 PF10447.9 CDI85341.1 - 0.00019 22.0 0.0 0.00025 21.6 0.0 1.2 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 PRP38_assoc PF12871.7 CDI85342.1 - 0.49 11.0 135.7 18 6.0 44.0 3.5 1 1 2 3 3 3 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Ninjurin PF04923.12 CDI85343.1 - 0.0017 18.3 1.3 0.0053 16.7 1.3 2.0 1 0 0 1 1 1 1 Ninjurin LPG_synthase_TM PF03706.13 CDI85343.1 - 0.03 13.8 6.1 0.041 13.4 6.1 1.1 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region Syndecan PF01034.20 CDI85343.1 - 0.2 11.6 1.8 0.31 11.0 0.0 2.3 2 0 0 2 2 2 0 Syndecan domain Glycophorin_A PF01102.18 CDI85343.1 - 0.33 11.2 0.0 0.33 11.2 0.0 3.9 2 1 1 3 3 3 0 Glycophorin A DUF898 PF05987.13 CDI85343.1 - 1.9 7.4 5.1 1.4 7.9 3.0 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) Sulf_transp PF04143.14 CDI85343.1 - 3 7.3 8.7 1.4 8.4 4.9 1.9 1 1 1 2 2 2 0 Sulphur transport DUF2298 PF10060.9 CDI85343.1 - 9.7 4.8 8.3 8.6 4.9 1.7 1.9 1 1 1 2 2 2 0 Uncharacterized membrane protein (DUF2298) SARAF PF06682.12 CDI85344.1 - 0.00059 19.6 9.3 0.00063 19.5 9.3 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis CDC45 PF02724.14 CDI85344.1 - 0.015 13.7 10.2 0.016 13.5 10.2 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 CDI85344.1 - 0.019 14.0 4.9 0.018 14.0 4.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CENP-L PF13092.6 CDI85344.1 - 0.022 15.0 1.3 0.022 15.0 1.3 2.1 2 0 0 2 2 2 0 Kinetochore complex Sim4 subunit Fta1 Chorein_N PF12624.7 CDI85344.1 - 0.022 14.9 0.8 0.022 14.9 0.8 2.2 2 0 0 2 2 2 0 N-terminal region of Chorein or VPS13 WTX PF09422.10 CDI85344.1 - 0.024 13.7 9.1 0.024 13.7 9.1 1.1 1 0 0 1 1 1 0 WTX protein DUF2828 PF11443.8 CDI85344.1 - 0.045 11.9 9.8 0.053 11.6 9.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4175 PF13779.6 CDI85344.1 - 0.068 11.1 33.9 0.082 10.8 33.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ANAPC_CDC26 PF10471.9 CDI85344.1 - 0.071 14.0 8.5 0.071 14.0 8.5 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 BORG_CEP PF14957.6 CDI85344.1 - 0.071 14.3 6.3 0.081 14.1 6.3 1.3 1 0 0 1 1 1 0 Cdc42 effector XRN_M PF17846.1 CDI85344.1 - 0.085 11.8 9.4 0.1 11.5 9.4 1.1 1 0 0 1 1 1 0 Xrn1 helical domain RR_TM4-6 PF06459.12 CDI85344.1 - 0.14 12.0 13.4 0.18 11.6 13.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI85344.1 - 0.16 10.2 23.4 0.16 10.2 23.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FAM60A PF15396.6 CDI85344.1 - 0.27 11.2 9.7 0.34 10.9 9.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF4770 PF15994.5 CDI85344.1 - 0.28 11.4 16.8 1.2 9.4 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) MAJIN PF15077.6 CDI85344.1 - 0.32 10.8 6.4 0.43 10.3 6.4 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Peroxin-13_N PF04088.13 CDI85344.1 - 0.33 11.2 7.9 6.3 7.1 4.3 2.1 2 0 0 2 2 2 0 Peroxin 13, N-terminal region SLC12 PF03522.15 CDI85344.1 - 0.38 9.7 13.3 0.44 9.5 13.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI85344.1 - 0.49 8.5 12.4 0.5 8.4 12.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Zip PF02535.22 CDI85344.1 - 0.51 9.5 5.9 0.55 9.4 5.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SKA1 PF07160.12 CDI85344.1 - 0.52 10.1 13.7 0.55 10.0 13.7 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 ALMT PF11744.8 CDI85344.1 - 0.55 9.0 8.3 0.61 8.8 8.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter AUX_IAA PF02309.16 CDI85344.1 - 0.83 9.5 7.8 0.88 9.4 7.8 1.2 1 0 0 1 1 1 0 AUX/IAA family Presenilin PF01080.17 CDI85344.1 - 1.1 7.9 20.4 1.4 7.6 20.4 1.1 1 0 0 1 1 1 0 Presenilin Nop53 PF07767.11 CDI85344.1 - 1.1 8.5 18.8 1.8 7.9 18.8 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Gti1_Pac2 PF09729.9 CDI85344.1 - 1.2 9.2 11.6 1.8 8.6 11.6 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family PIP5K PF01504.18 CDI85344.1 - 1.4 8.1 11.9 1.9 7.6 11.9 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase CLN3 PF02487.17 CDI85344.1 - 1.5 7.8 9.9 1.8 7.6 9.9 1.1 1 0 0 1 1 1 0 CLN3 protein CDK2AP PF09806.9 CDI85344.1 - 1.5 8.8 17.9 2.1 8.4 17.9 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DUF2126 PF09899.9 CDI85344.1 - 2.4 6.1 9.0 2.9 5.8 9.0 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF4667 PF15700.5 CDI85344.1 - 2.4 8.2 15.6 3.4 7.7 15.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) RNA_pol_Rbc25 PF08292.12 CDI85344.1 - 2.7 8.2 13.4 4.5 7.5 0.2 2.2 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 Lin-8 PF03353.15 CDI85344.1 - 3.4 7.2 18.9 4.7 6.7 18.9 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Myf5 PF12232.8 CDI85344.1 - 3.5 8.5 6.6 1.2 10.0 1.7 2.3 2 0 0 2 2 2 0 Myogenic determination factor 5 MRP-S26 PF14943.6 CDI85344.1 - 3.6 7.5 17.0 6.1 6.7 17.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 tRNA_synt_1c_R2 PF04557.15 CDI85344.1 - 4.5 8.3 12.8 6.1 7.8 5.9 2.2 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Mit_KHE1 PF10173.9 CDI85344.1 - 7.3 6.6 9.4 3.8 7.5 0.2 2.2 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related NPR3 PF03666.13 CDI85344.1 - 8.8 5.0 14.5 12 4.5 14.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 V_ATPase_I PF01496.19 CDI85344.1 - 9.5 4.0 19.2 12 3.6 19.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RskA PF10099.9 CDI85345.1 - 0.004 17.5 15.7 0.004 17.5 15.7 22.3 5 5 8 15 15 15 3 Anti-sigma-K factor rskA PRCC PF10253.9 CDI85345.1 - 0.0078 17.0 4.1 0.0078 17.0 4.1 14.5 6 3 3 11 11 11 1 Mitotic checkpoint regulator, MAD2B-interacting DUF2722 PF10846.8 CDI85346.1 - 0.00011 21.3 6.4 0.00011 21.3 6.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) ANAPC_CDC26 PF10471.9 CDI85346.1 - 0.0032 18.3 12.3 0.0032 18.3 12.3 1.8 2 0 0 2 2 1 1 Anaphase-promoting complex APC subunit CDC26 SpoIIP PF07454.11 CDI85346.1 - 0.0036 16.8 2.1 0.0047 16.4 2.1 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) AIM3 PF17096.5 CDI85346.1 - 0.0041 18.0 0.3 0.0066 17.4 0.3 1.2 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 3 TMEM51 PF15345.6 CDI85346.1 - 0.0063 16.4 2.8 0.0065 16.3 2.8 1.2 1 0 0 1 1 1 1 Transmembrane protein 51 Afi1 PF07792.12 CDI85346.1 - 0.011 16.2 3.7 0.017 15.6 3.7 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Presenilin PF01080.17 CDI85346.1 - 0.017 13.9 1.2 0.018 13.8 1.2 1.1 1 0 0 1 1 1 0 Presenilin DUF4820 PF16091.5 CDI85346.1 - 0.021 14.2 2.7 0.027 13.8 2.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) RPA43_OB PF17875.1 CDI85346.1 - 0.021 15.4 0.4 0.028 15.0 0.4 1.3 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I AKAP95 PF04988.12 CDI85346.1 - 0.023 14.9 3.4 0.035 14.3 3.4 1.2 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) Eapp_C PF10238.9 CDI85346.1 - 0.032 14.3 6.7 0.049 13.7 6.7 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein AIF_C PF14721.6 CDI85346.1 - 0.041 14.3 2.2 0.061 13.7 2.2 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term V_ATPase_I PF01496.19 CDI85346.1 - 0.041 11.8 0.5 0.035 12.0 0.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CPSF100_C PF13299.6 CDI85346.1 - 0.061 13.5 2.7 0.13 12.4 2.6 1.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Spt20 PF12090.8 CDI85346.1 - 0.063 12.9 18.3 0.1 12.2 18.3 1.3 1 0 0 1 1 1 0 Spt20 family Connexin PF00029.19 CDI85346.1 - 0.065 13.0 2.4 0.093 12.5 2.4 1.2 1 0 0 1 1 1 0 Connexin Tim54 PF11711.8 CDI85346.1 - 0.074 11.8 3.3 0.093 11.5 3.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CSG2 PF16965.5 CDI85346.1 - 0.11 11.4 0.3 0.13 11.2 0.3 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Pex14_N PF04695.13 CDI85346.1 - 0.13 12.9 7.4 0.11 13.1 6.0 1.6 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FHIPEP PF00771.20 CDI85346.1 - 0.14 10.6 2.3 0.18 10.2 2.3 1.2 1 0 0 1 1 1 0 FHIPEP family Suf PF05843.14 CDI85346.1 - 0.16 12.0 5.5 0.22 11.5 5.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) eIF3_subunit PF08597.10 CDI85346.1 - 0.16 11.9 12.2 13 5.6 0.0 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit MscS_TM PF12794.7 CDI85346.1 - 0.18 10.6 7.5 0.24 10.2 7.5 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 ORC_WH_C PF18137.1 CDI85346.1 - 0.18 11.8 5.9 0.34 11.0 5.9 1.4 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Ctr PF04145.15 CDI85346.1 - 0.22 12.1 0.4 0.28 11.8 0.4 1.2 1 0 0 1 1 1 0 Ctr copper transporter family ALMT PF11744.8 CDI85346.1 - 0.23 10.2 1.1 0.27 10.0 1.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter MTP18 PF10558.9 CDI85346.1 - 0.28 11.1 1.2 0.4 10.6 1.2 1.2 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) U1snRNP70_N PF12220.8 CDI85346.1 - 0.29 11.8 11.7 0.3 11.8 10.3 1.7 2 0 0 2 2 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF3464 PF11947.8 CDI85346.1 - 0.34 10.7 4.6 0.52 10.1 4.6 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF4834 PF16118.5 CDI85346.1 - 0.45 11.5 9.2 0.78 10.7 9.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TERB2 PF15101.6 CDI85346.1 - 0.47 10.5 8.0 0.31 11.1 6.2 1.6 2 0 0 2 2 2 0 Telomere-associated protein TERB2 SKIP_SNW PF02731.15 CDI85346.1 - 0.79 9.4 11.0 1.3 8.7 11.0 1.2 1 0 0 1 1 1 0 SKIP/SNW domain Sec62 PF03839.16 CDI85346.1 - 0.85 9.1 10.0 1.5 8.3 10.0 1.3 1 1 0 1 1 1 0 Translocation protein Sec62 UPF0560 PF10577.9 CDI85346.1 - 1.5 7.2 8.7 2 6.8 8.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 G0-G1_switch_2 PF15103.6 CDI85346.1 - 1.6 9.2 7.0 2.9 8.4 7.0 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 Coilin_N PF15862.5 CDI85346.1 - 2.7 7.8 10.3 4.2 7.2 10.3 1.3 1 0 0 1 1 1 0 Coilin N-terminus EIIBC-GUT_N PF03612.14 CDI85346.1 - 3 7.6 6.4 4.4 7.0 6.4 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF1682 PF07946.14 CDI85346.1 - 3.9 6.6 10.7 5.9 6.0 10.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Roughex PF06020.11 CDI85346.1 - 4.5 6.3 10.0 5.6 5.9 10.0 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Med3 PF11593.8 CDI85346.1 - 8.8 5.4 13.8 1.8 7.7 10.8 1.4 2 0 0 2 2 1 0 Mediator complex subunit 3 fungal Baculo_PP31 PF05311.11 CDI85348.1 - 4.1 6.8 16.5 4.2 6.8 16.5 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) N6_N4_Mtase PF01555.18 CDI85350.1 - 0.28 10.9 6.7 1.7 8.3 0.1 2.2 2 0 0 2 2 2 0 DNA methylase DUF3402 PF11882.8 CDI85350.1 - 2.7 7.0 30.0 0.17 10.9 12.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3402) Connexin PF00029.19 CDI85350.1 - 3.5 7.3 17.5 0.74 9.5 2.0 2.5 2 0 0 2 2 2 0 Connexin DUF4647 PF15504.6 CDI85350.1 - 5.2 6.1 47.6 0.086 11.9 18.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4647) Fibrinogen_BP PF08017.11 CDI85352.1 - 4.8e-07 28.6 56.0 5.6e-07 28.3 56.0 1.0 1 0 0 1 1 1 1 Fibrinogen binding protein Otopetrin PF03189.13 CDI85353.1 - 7.2e-08 31.7 19.6 0.018 13.9 0.0 5.9 2 2 0 2 2 2 1 Otopetrin DUF2722 PF10846.8 CDI85353.1 - 0.00022 20.3 7.6 0.00022 20.3 7.6 13.7 9 3 2 12 12 12 4 Protein of unknown function (DUF2722) Afi1 PF07792.12 CDI85353.1 - 0.0015 19.1 0.0 0.0015 19.1 0.0 9.1 6 2 1 7 7 7 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Spt20 PF12090.8 CDI85353.1 - 0.0048 16.6 14.4 0.0048 16.6 14.4 12.7 8 3 3 12 12 12 4 Spt20 family SOG2 PF10428.9 CDI85354.1 - 0.66 9.1 14.7 1.2 8.3 14.7 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein TFIIA PF03153.13 CDI85355.1 - 0.00021 21.4 25.1 0.00021 21.4 25.1 4.1 4 0 0 4 4 4 3 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI85355.1 - 0.00039 19.3 16.2 0.00039 19.3 16.2 3.3 3 0 0 3 3 3 1 Presenilin DUF898 PF05987.13 CDI85355.1 - 0.034 13.2 0.0 0.066 12.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) DUF2052 PF09747.9 CDI85355.1 - 2.7 8.1 39.4 0.086 13.0 26.9 2.4 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) XRN_M PF17846.1 CDI85355.1 - 5.4 5.8 18.4 0.85 8.5 12.1 2.3 2 0 0 2 2 2 0 Xrn1 helical domain Methyltransf_29 PF03141.16 CDI85355.1 - 5.8 5.3 11.6 11 4.4 11.6 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF4045 PF13254.6 CDI85356.1 - 5.1 6.6 22.8 6.5 6.3 22.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SLC12 PF03522.15 CDI85356.1 - 7.6 5.4 8.1 7.7 5.4 8.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF5585 PF17823.1 CDI85356.1 - 8.1 5.3 49.9 9.9 5.0 49.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5585) GT87 PF09594.10 CDI85358.1 - 0.0043 16.8 2.8 0.0043 16.8 2.8 2.2 2 0 0 2 2 2 2 Glycosyltransferase family 87 DUF4148 PF13663.6 CDI85358.1 - 2.6 8.3 34.0 0.28 11.4 3.7 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4148) USP19_linker PF16602.5 CDI85358.1 - 3.9 8.1 12.1 9.3 6.8 2.3 2.3 2 0 0 2 2 2 0 Linker region of USP19 deubiquitinase DUF4088 PF13317.6 CDI85358.1 - 4.6 6.7 11.1 4.9 6.6 4.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4088) TFIIA PF03153.13 CDI85358.1 - 8.8 6.2 20.9 12 5.8 20.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TfoX_N PF04993.13 CDI85359.1 - 7.4 6.9 10.3 23 5.3 5.5 3.1 2 0 0 2 2 2 0 TfoX N-terminal domain SPX PF03105.19 CDI85360.1 - 0.0074 16.3 2.5 0.0074 16.3 2.5 2.2 2 0 0 2 2 2 1 SPX domain BUD22 PF09073.10 CDI85360.1 - 0.14 11.5 36.1 0.045 13.1 20.6 2.3 2 0 0 2 2 2 0 BUD22 Sporozoite_P67 PF05642.11 CDI85360.1 - 0.57 8.2 55.5 0.0039 15.4 20.8 2.4 1 1 1 2 2 2 0 Sporozoite P67 surface antigen EPL1 PF10513.9 CDI85360.1 - 0.6 10.5 24.6 2.7 8.4 5.8 2.7 2 0 0 2 2 2 0 Enhancer of polycomb-like PTPRCAP PF15713.5 CDI85360.1 - 0.92 9.8 37.4 2.5 8.4 10.8 2.7 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated CNDH2_C PF16858.5 CDI85360.1 - 1.1 9.0 23.1 0.5 10.2 7.8 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Apt1 PF10351.9 CDI85360.1 - 1.2 7.9 27.2 0.087 11.7 3.4 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain YfhO PF09586.10 CDI85360.1 - 1.4 7.1 7.3 2.4 6.3 7.3 1.3 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF2052 PF09747.9 CDI85360.1 - 2 8.5 32.5 0.62 10.2 15.2 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SDA1 PF05285.12 CDI85360.1 - 2.9 7.2 29.6 0.9 8.9 16.0 2.4 2 0 0 2 2 2 0 SDA1 Lin-8 PF03353.15 CDI85360.1 - 3.5 7.1 44.6 0.49 9.9 19.0 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist SpoIIP PF07454.11 CDI85360.1 - 3.7 6.9 24.6 4.6 6.6 8.9 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) AF-4 PF05110.13 CDI85360.1 - 4 5.4 48.5 0.25 9.4 14.9 2.3 2 0 0 2 2 2 0 AF-4 proto-oncoprotein DUF4746 PF15928.5 CDI85360.1 - 5.2 6.4 28.7 4.5 6.6 5.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) PI3K_1B_p101 PF10486.9 CDI85360.1 - 5.8 4.6 27.7 2.6 5.7 14.6 2.1 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Nop25 PF09805.9 CDI85360.1 - 6 7.3 29.9 3 8.3 8.7 2.5 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Plasmodium_Vir PF05795.11 CDI85360.1 - 8 5.8 27.5 1.8 7.9 6.4 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein MAT1 PF06391.13 CDI85360.1 - 8.9 6.1 32.4 4 7.2 14.3 2.3 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Tim54 PF11711.8 CDI85362.1 - 2.1e-06 26.8 14.3 2.9e-06 26.3 14.3 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Glt_symporter PF03616.14 CDI85362.1 - 0.0049 15.6 1.3 0.0049 15.6 1.3 3.0 2 1 1 3 3 3 1 Sodium/glutamate symporter zf-C2H2_3rep PF18868.1 CDI85362.1 - 0.047 14.4 23.7 0.65 10.7 3.5 3.0 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats Porin_4 PF13609.6 CDI85362.1 - 0.42 10.3 2.1 0.57 9.9 2.1 1.2 1 0 0 1 1 1 0 Gram-negative porin Thg1C PF14413.6 CDI85362.1 - 0.55 10.4 26.4 0.11 12.6 0.7 3.2 3 0 0 3 3 3 0 Thg1 C terminal domain DUF5523 PF17661.1 CDI85362.1 - 0.74 9.4 34.3 0.028 14.1 16.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) RR_TM4-6 PF06459.12 CDI85362.1 - 5.1 6.8 32.2 3.3 7.5 18.7 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 PBP1_TM PF14812.6 CDI85362.1 - 6.3 7.3 13.7 1.9 8.9 1.8 3.1 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal IHABP4_N PF16174.5 CDI85362.1 - 7.3 7.2 36.2 0.25 11.9 18.7 2.4 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal INSIG PF07281.12 CDI85362.1 - 7.8 6.1 19.6 6.2 6.4 2.2 2.5 2 1 0 2 2 2 0 Insulin-induced protein (INSIG) Conotoxin PF02950.17 CDI85362.1 - 8 7.6 31.6 2.3 9.3 2.9 3.4 3 0 0 3 3 3 0 Conotoxin EphA2_TM PF14575.6 CDI85363.1 - 0.22 12.4 1.6 0.82 10.6 0.5 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain RskA PF10099.9 CDI85363.1 - 1.9 8.7 46.9 0.82 9.9 0.1 2.9 1 1 2 3 3 3 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI85363.1 - 2.4 8.1 31.6 2.8 7.8 31.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SOBP PF15279.6 CDI85363.1 - 2.5 8.6 20.5 2.9 8.4 20.5 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4551 PF15087.6 CDI85363.1 - 6.1 5.6 13.6 6.7 5.4 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF3328 PF11807.8 CDI85364.1 - 0.069 12.9 0.1 9 6.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) EGL-1 PF11430.8 CDI85364.1 - 1.3 9.0 3.6 47 4.0 0.0 3.1 3 0 0 3 3 3 0 Programmed cell death activator EGL-1 Activator_LAG-3 PF11498.8 CDI85365.1 - 0.00021 20.4 82.6 0.00021 20.4 82.6 4.1 1 1 2 3 3 3 1 Transcriptional activator LAG-3 Rft-1 PF04506.13 CDI85366.1 - 1.7e-09 37.0 0.1 2.5e-09 36.4 0.1 1.1 1 0 0 1 1 1 1 Rft protein Sad1_UNC PF07738.13 CDI85367.1 - 1.1e-13 51.4 0.0 2.1e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Methyltransf_25 PF13649.6 CDI85368.1 - 0.16 12.7 0.0 0.41 11.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain APG17 PF04108.12 CDI85372.1 - 0.0053 15.9 4.9 0.0092 15.1 4.9 1.3 1 0 0 1 1 1 1 Autophagy protein Apg17 PCRF PF03462.18 CDI85372.1 - 0.0077 16.1 3.1 0.016 15.1 3.1 1.5 1 0 0 1 1 1 1 PCRF domain CorA PF01544.18 CDI85372.1 - 0.02 14.2 2.7 0.043 13.1 2.7 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein MIT PF04212.18 CDI85372.1 - 0.022 14.8 4.5 2.8 8.1 0.4 2.9 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Fib_alpha PF08702.10 CDI85372.1 - 0.023 14.9 0.7 0.31 11.2 0.2 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4795 PF16043.5 CDI85372.1 - 0.048 13.3 2.6 0.15 11.6 2.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) PIN_8 PF18476.1 CDI85372.1 - 0.22 11.3 4.0 2 8.2 1.0 2.4 2 0 0 2 2 2 0 PIN like domain Ubiq_cyt_C_chap PF03981.12 CDI85372.1 - 0.26 11.4 2.5 1.1 9.4 1.2 2.5 2 1 0 2 2 2 0 Ubiquinol-cytochrome C chaperone zf-HC2 PF13490.6 CDI85372.1 - 0.29 11.4 1.8 8.5 6.7 0.7 3.3 3 0 0 3 3 3 0 Putative zinc-finger DUF948 PF06103.11 CDI85372.1 - 0.45 10.8 2.2 11 6.4 2.3 2.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF883 PF05957.13 CDI85372.1 - 0.66 10.6 10.2 0.33 11.6 5.7 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF4407 PF14362.6 CDI85372.1 - 2.4 7.4 8.2 4.8 6.5 8.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 CDI85372.1 - 2.7 8.0 3.6 2.9 8.0 1.6 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 CDI85372.1 - 5.8 7.0 5.9 5.5 7.0 1.7 3.0 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 CDI85372.1 - 7.2 6.4 21.3 2.2 8.1 15.0 2.8 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain ThiF PF00899.21 CDI85373.1 - 2.8e-55 187.3 0.0 9.3e-35 120.1 0.0 4.2 4 1 0 4 4 4 3 ThiF family UBA_e1_thiolCys PF10585.9 CDI85373.1 - 2.6e-07 30.8 0.0 0.95 9.3 0.0 3.6 3 0 0 3 3 3 3 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.20 CDI85373.1 - 0.00017 21.7 0.3 0.36 10.9 0.0 3.0 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CDI85373.1 - 0.00084 18.7 0.0 0.21 10.9 0.0 3.1 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 CDI85373.1 - 0.0079 15.5 0.2 2.5 7.3 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Stevor PF17410.2 CDI85373.1 - 0.016 14.8 1.4 0.055 13.0 1.4 1.9 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Pyr_redox PF00070.27 CDI85373.1 - 0.05 14.2 0.9 6.2 7.5 0.2 3.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase E1_UFD PF09358.10 CDI85373.1 - 0.064 14.0 0.0 0.16 12.7 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin fold domain RIC1 PF07064.13 CDI85374.1 - 0.00092 18.7 0.0 0.0019 17.7 0.0 1.4 1 0 0 1 1 1 1 RIC1 Chordopox_A33R PF05966.12 CDI85375.1 - 0.16 11.2 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirus A33R protein TFIIA PF03153.13 CDI85377.1 - 0.1 12.6 32.2 0.14 12.2 32.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI85377.1 - 1.7 6.9 25.8 1.8 6.8 25.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI85377.1 - 5.6 4.0 19.9 6.8 3.7 19.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer KAR9 PF08580.10 CDI85379.1 - 4.1 5.8 8.5 4.2 5.8 8.5 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 DUF4614 PF15391.6 CDI85380.1 - 0.13 12.3 24.0 0.16 12.0 24.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Mitofilin PF09731.9 CDI85380.1 - 3.2 6.5 18.1 3.5 6.4 18.1 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein NST1 PF13945.6 CDI85380.1 - 5.8 7.0 17.4 7.3 6.6 17.4 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Hamartin PF04388.12 CDI85382.1 - 0.039 12.6 33.0 0.056 12.1 33.0 1.3 1 0 0 1 1 1 0 Hamartin protein LMBR1 PF04791.16 CDI85382.1 - 0.08 11.8 13.7 0.13 11.1 13.7 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4342 PF14242.6 CDI85382.1 - 0.12 12.4 0.3 0.12 12.4 0.3 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4342) GREB1 PF15782.5 CDI85382.1 - 0.46 7.5 42.6 0.59 7.2 42.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LAP1C PF05609.12 CDI85382.1 - 0.62 9.1 47.3 0.86 8.6 47.3 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) LptF_LptG PF03739.14 CDI85382.1 - 0.73 8.6 17.3 4.3 6.1 0.1 2.1 1 1 1 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG ETRAMP PF09716.10 CDI85382.1 - 2.7 8.1 0.0 2.7 8.1 0.0 4.2 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) CPW_WPC PF09717.10 CDI85383.1 - 2.6e-18 66.8 7.1 6.1e-15 55.9 2.3 2.5 2 0 0 2 2 2 2 Plasmodium falciparum domain of unknown function (CPW_WPC) Spt20 PF12090.8 CDI85383.1 - 0.0006 19.5 10.7 0.0006 19.5 10.7 1.1 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI85383.1 - 0.0013 17.7 8.4 0.0015 17.5 8.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF4518 PF15008.6 CDI85383.1 - 0.0099 15.1 1.8 0.01 15.1 1.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4518) TFIIA PF03153.13 CDI85383.1 - 0.011 15.8 9.6 0.011 15.8 9.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1744 PF08490.12 CDI85383.1 - 0.026 13.1 0.8 0.037 12.6 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1744) zf-rbx1 PF12678.7 CDI85383.1 - 0.05 13.9 6.1 1.4 9.3 0.6 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain SurA_N_2 PF13623.6 CDI85383.1 - 0.072 12.9 15.0 0.1 12.4 15.0 1.1 1 0 0 1 1 1 0 SurA N-terminal domain DUF4407 PF14362.6 CDI85383.1 - 0.11 11.8 2.2 0.12 11.7 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RED_N PF07808.13 CDI85383.1 - 1.7 8.1 9.1 2.4 7.7 9.1 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region UPF0560 PF10577.9 CDI85383.1 - 5.5 5.4 8.7 6.2 5.2 8.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Med15 PF09606.10 CDI85383.1 - 8.7 4.9 18.8 11 4.6 18.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SLBP_RNA_bind PF15247.6 CDI85384.1 - 2e-17 63.0 1.4 2e-17 63.0 1.4 4.0 2 1 1 3 3 3 1 Histone RNA hairpin-binding protein RNA-binding domain Lin-8 PF03353.15 CDI85384.1 - 0.00094 18.8 7.4 0.00094 18.8 7.4 3.8 3 1 0 3 3 3 1 Ras-mediated vulval-induction antagonist Shadoo PF14999.6 CDI85385.1 - 0.018 15.2 8.8 0.37 10.9 1.5 2.1 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Ribosomal_60s PF00428.19 CDI85385.1 - 0.21 12.2 19.5 1.6 9.4 3.1 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF4775 PF16001.5 CDI85385.1 - 9.8 5.5 25.0 15 4.8 25.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) RskA PF10099.9 CDI85388.1 - 0.00016 22.0 2.4 0.00019 21.8 2.4 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA MLANA PF14991.6 CDI85388.1 - 0.0051 17.1 1.1 0.0063 16.8 1.1 1.2 1 0 0 1 1 1 1 Protein melan-A WBP-1 PF11669.8 CDI85388.1 - 0.1 13.2 7.1 0.17 12.5 7.1 1.4 1 0 0 1 1 1 0 WW domain-binding protein 1 FAM222A PF15258.6 CDI85388.1 - 1.8 7.6 18.5 1.8 7.6 18.5 1.1 1 0 0 1 1 1 0 Protein family of FAM222A SET PF00856.28 CDI85389.1 - 0.00015 22.2 0.0 0.036 14.4 0.0 2.9 1 1 1 2 2 2 2 SET domain RskA PF10099.9 CDI85390.1 - 0.0013 19.1 7.4 0.0013 19.1 7.4 3.1 1 1 2 3 3 3 1 Anti-sigma-K factor rskA Tfb2 PF03849.14 CDI85391.1 - 8.8e-14 51.2 6.2 1.6e-07 30.7 6.8 3.1 2 1 0 2 2 2 2 Transcription factor Tfb2 RskA PF10099.9 CDI85391.1 - 0.0078 16.5 16.5 0.049 13.9 11.5 2.3 2 0 0 2 2 2 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI85391.1 - 0.0085 15.7 1.9 0.0085 15.7 1.9 2.5 3 0 0 3 3 3 1 Spt20 family baeRF_family8 PF18851.1 CDI85391.1 - 0.012 15.7 0.5 0.024 14.7 0.5 1.5 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 8 TFIIA PF03153.13 CDI85391.1 - 0.025 14.6 30.4 0.24 11.4 16.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Mlh1_C PF16413.5 CDI85391.1 - 0.031 13.6 1.2 0.076 12.4 0.2 2.1 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus DUF2722 PF10846.8 CDI85391.1 - 1.6 7.6 33.0 0.018 14.0 7.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) dsDNA_bind PF01984.20 CDI85391.1 - 3.8 7.8 19.4 0.52 10.6 5.9 3.2 3 0 0 3 3 3 0 Double-stranded DNA-binding domain Secretin_N_2 PF07655.13 CDI85391.1 - 4.4 7.9 39.1 2.9 8.5 10.2 3.5 3 0 0 3 3 3 0 Secretin N-terminal domain SR-25 PF10500.9 CDI85391.1 - 8.8 5.9 65.1 0.024 14.2 17.0 4.1 3 1 0 3 3 2 0 Nuclear RNA-splicing-associated protein SPX PF03105.19 CDI85391.1 - 8.8 6.1 32.8 32 4.3 32.9 1.8 1 1 0 1 1 1 0 SPX domain Cullin PF00888.22 CDI85392.1 - 9.8e-13 47.6 0.1 2.6e-08 33.0 0.0 2.3 1 1 1 2 2 2 2 Cullin family DUF2722 PF10846.8 CDI85392.1 - 0.00029 19.9 1.1 0.00039 19.5 1.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF3446 PF11928.8 CDI85392.1 - 0.0063 16.8 2.7 0.013 15.8 2.7 1.5 1 0 0 1 1 1 1 Early growth response N-terminal domain CNDH2_M PF16869.5 CDI85392.1 - 0.048 14.4 3.5 0.23 12.1 0.2 2.4 2 0 0 2 2 2 0 PF16858 Suf PF05843.14 CDI85392.1 - 1.6 8.7 4.3 0.56 10.1 1.6 1.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Activator_LAG-3 PF11498.8 CDI85392.1 - 5 6.0 17.6 10 5.0 17.6 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 HRXXH PF13933.6 CDI85393.1 - 0.2 11.2 6.5 0.21 11.1 6.5 1.1 1 0 0 1 1 1 0 Putative peptidase family Spt20 PF12090.8 CDI85393.1 - 0.88 9.1 44.9 0.91 9.1 44.9 1.0 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 CDI85393.1 - 3.8 6.3 34.7 4 6.3 34.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI85393.1 - 4.4 7.9 20.8 4.6 7.9 20.8 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PepSY_TM PF03929.16 CDI85393.1 - 6.6 6.3 10.0 6.1 6.4 10.0 1.0 1 0 0 1 1 1 0 PepSY-associated TM region EIIBC-GUT_N PF03612.14 CDI85393.1 - 7.3 6.3 14.9 7.1 6.3 14.9 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TFB6 PF17110.5 CDI85393.1 - 7.5 6.3 11.9 7.6 6.2 11.9 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF775 PF05603.12 CDI85393.1 - 8.6 5.8 15.6 9.3 5.7 15.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) FAM176 PF14851.6 CDI85393.1 - 9.2 5.9 12.3 11 5.7 12.3 1.2 1 0 0 1 1 1 0 FAM176 family Rxt3 PF08642.10 CDI85393.1 - 9.7 7.0 10.1 10 6.9 10.1 1.3 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 CobT PF06213.12 CDI85393.1 - 9.8 5.5 23.0 9.5 5.5 23.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TFIIA PF03153.13 CDI85394.1 - 0.0003 20.9 59.7 0.0003 20.9 59.7 27.2 2 2 23 25 25 25 1 Transcription factor IIA, alpha/beta subunit Utp14 PF04615.13 CDI85394.1 - 0.00038 19.2 10.7 0.00038 19.2 10.7 18.1 4 2 11 17 17 17 1 Utp14 protein RskA PF10099.9 CDI85394.1 - 0.00047 20.5 0.0 0.00047 20.5 0.0 51.0 8 6 24 32 32 32 4 Anti-sigma-K factor rskA CSG2 PF16965.5 CDI85395.1 - 0.0048 15.9 4.7 0.0048 15.9 4.7 2.3 2 0 0 2 2 2 1 Ceramide synthase regulator DUF2637 PF10935.8 CDI85395.1 - 0.024 14.5 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2637) DUF4519 PF15012.6 CDI85395.1 - 0.073 13.2 0.1 0.073 13.2 0.1 4.5 4 1 0 4 4 4 0 Domain of unknown function (DUF4519) GntP_permease PF02447.16 CDI85395.1 - 0.099 11.3 0.1 0.25 10.0 0.1 1.7 1 0 0 1 1 1 0 GntP family permease DUF4448 PF14610.6 CDI85395.1 - 0.31 10.8 0.1 0.31 10.8 0.1 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF4448) Secretin_N_2 PF07655.13 CDI85396.1 - 1.6 9.3 12.9 0.3 11.7 9.3 1.7 2 0 0 2 2 2 0 Secretin N-terminal domain KIAA1328 PF15369.6 CDI85398.1 - 0.0025 17.7 20.0 0.0025 17.7 20.0 2.2 2 0 0 2 2 2 1 Uncharacterised protein KIAA1328 Pkinase PF00069.25 CDI85399.1 - 3.7e-45 154.4 0.8 3.2e-31 108.7 0.0 2.9 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI85399.1 - 3.5e-16 59.3 0.0 1.5e-12 47.4 0.0 3.3 3 1 1 4 4 4 2 Protein tyrosine kinase AMP-binding PF00501.28 CDI85400.1 - 3.2e-37 128.1 0.0 4.7e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDI85400.1 - 3e-05 24.9 0.2 5.5e-05 24.1 0.2 1.6 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain NYN_YacP PF05991.11 CDI85400.1 - 0.016 15.1 0.1 0.024 14.6 0.1 1.3 1 0 0 1 1 1 0 YacP-like NYN domain Creatinase_N PF01321.18 CDI85400.1 - 0.017 15.7 0.1 0.027 15.1 0.1 1.3 1 0 0 1 1 1 0 Creatinase/Prolidase N-terminal domain SBP_bac_11 PF13531.6 CDI85400.1 - 0.033 13.9 0.0 0.044 13.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein RskA PF10099.9 CDI85401.1 - 0.021 15.1 35.4 0.74 10.1 0.9 4.4 3 1 1 4 4 4 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI85401.1 - 0.05 13.6 13.3 0.085 12.8 13.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI85402.1 - 0.0032 17.8 13.7 0.0032 17.8 13.7 2.2 1 1 1 2 2 2 1 Anti-sigma-K factor rskA PRP1_N PF06424.12 CDI85402.1 - 0.011 16.2 9.1 0.098 13.1 1.3 2.2 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Presenilin PF01080.17 CDI85402.1 - 0.027 13.2 15.6 0.031 13.0 15.6 1.3 1 0 0 1 1 1 0 Presenilin DUF572 PF04502.13 CDI85402.1 - 0.03 14.0 8.1 0.04 13.5 8.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4710 PF15828.5 CDI85402.1 - 0.21 11.8 5.2 0.71 10.0 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Spt20 PF12090.8 CDI85402.1 - 0.22 11.1 52.0 0.082 12.5 22.7 2.1 2 0 0 2 2 2 0 Spt20 family DUF2052 PF09747.9 CDI85402.1 - 0.3 11.2 14.4 0.49 10.5 14.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Ndc1_Nup PF09531.10 CDI85402.1 - 0.43 9.2 19.2 0.54 8.9 19.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MAT1 PF06391.13 CDI85402.1 - 0.69 9.7 19.7 1 9.1 19.7 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 CobT PF06213.12 CDI85402.1 - 0.81 9.0 24.7 0.34 10.3 9.8 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Miff PF05644.11 CDI85402.1 - 0.94 9.0 19.1 1.4 8.4 19.1 1.2 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff SLC12 PF03522.15 CDI85402.1 - 1.1 8.2 16.8 1.4 7.8 16.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF5327 PF17261.2 CDI85402.1 - 1.2 9.9 25.4 2.5 8.9 10.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5327) EIF4E-T PF10477.9 CDI85402.1 - 1.5 7.6 24.4 1.8 7.3 24.4 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Otopetrin PF03189.13 CDI85402.1 - 1.6 7.4 8.9 2.5 6.8 8.9 1.3 1 0 0 1 1 1 0 Otopetrin Orf78 PF06024.12 CDI85402.1 - 2.8 8.3 12.3 7.3 7.0 2.1 2.3 2 0 0 2 2 2 0 Orf78 (ac78) MDM10 PF12519.8 CDI85402.1 - 2.8 6.7 12.0 4.3 6.1 12.0 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF4834 PF16118.5 CDI85402.1 - 3 8.8 25.4 1.9 9.5 9.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Coilin_N PF15862.5 CDI85402.1 - 3.1 7.6 20.5 4 7.3 4.6 2.1 2 0 0 2 2 2 0 Coilin N-terminus XRN_M PF17846.1 CDI85402.1 - 3.5 6.5 13.5 4.5 6.1 13.5 1.1 1 0 0 1 1 1 0 Xrn1 helical domain YjbH PF06082.11 CDI85402.1 - 4.1 6.1 13.9 5.4 5.7 13.9 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH ATAD4 PF15321.6 CDI85402.1 - 5.2 8.5 14.4 8.1 7.9 4.5 2.4 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 DUF4770 PF15994.5 CDI85402.1 - 5.3 7.3 19.0 3.4 7.9 7.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Peroxin-3 PF04882.12 CDI85402.1 - 7.7 5.4 21.7 11 4.9 21.7 1.1 1 0 0 1 1 1 0 Peroxin-3 DUF3486 PF11985.8 CDI85403.1 - 6.8 7.1 16.1 7.6 6.9 16.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3486) Apt1 PF10351.9 CDI85404.1 - 0.066 12.1 12.4 0.066 12.1 12.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 CDI85404.1 - 0.5 9.5 26.5 0.64 9.2 26.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF2062 PF09835.9 CDI85404.1 - 0.68 9.8 5.7 1 9.2 5.7 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) DUF4813 PF16072.5 CDI85404.1 - 1 9.0 21.4 1.4 8.5 21.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Arabinose_trans PF04602.12 CDI85404.1 - 1.1 8.0 12.5 1.4 7.6 12.5 1.1 1 0 0 1 1 1 0 Mycobacterial cell wall arabinan synthesis protein Peptidase_S64 PF08192.11 CDI85404.1 - 9.8 4.5 16.5 10 4.5 16.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 Mito_carr PF00153.27 CDI85405.1 - 0.0027 17.6 0.3 0.0027 17.6 0.3 4.4 3 3 1 4 4 4 1 Mitochondrial carrier protein Peptidase_S64 PF08192.11 CDI85405.1 - 1.4 7.4 36.8 1.8 7.0 36.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 PAT1 PF09770.9 CDI85405.1 - 4.3 5.5 73.8 6.2 5.0 73.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 K_channel_TID PF07941.11 CDI85406.1 - 0.028 14.8 17.9 0.028 14.8 17.9 11.9 8 5 3 11 11 11 0 Potassium channel Kv1.4 tandem inactivation domain DUF4148 PF13663.6 CDI85406.1 - 0.74 10.1 34.8 1.3 9.3 1.4 6.2 5 0 0 5 5 5 0 Domain of unknown function (DUF4148) MORN PF02493.20 CDI85407.1 - 2.1e-30 102.8 34.2 3.8e-06 26.5 0.8 6.4 6 0 0 6 6 6 6 MORN repeat Spt20 PF12090.8 CDI85407.1 - 0.18 11.4 28.3 0.059 13.0 19.8 2.3 2 0 0 2 2 2 0 Spt20 family Macoilin PF09726.9 CDI85407.1 - 0.37 9.3 4.3 0.67 8.4 4.3 1.4 1 0 0 1 1 1 0 Macoilin family Med15 PF09606.10 CDI85407.1 - 3 6.4 29.0 0.12 11.0 20.4 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal UPF0560 PF10577.9 CDI85407.1 - 3.8 5.9 9.6 5.7 5.3 9.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF755 PF05501.11 CDI85408.1 - 0.0015 18.8 9.8 0.0015 18.8 9.8 4.8 4 1 0 4 4 4 1 Domain of unknown function (DUF755) SUIM_assoc PF16619.5 CDI85408.1 - 0.0021 18.1 37.2 0.17 12.0 1.5 4.2 3 0 0 3 3 3 3 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI85408.1 - 0.0021 18.4 1.2 0.0021 18.4 1.2 6.8 2 1 2 5 5 5 3 Anti-sigma-K factor rskA BRCA-2_OB1 PF09103.10 CDI85408.1 - 0.023 14.6 0.0 0.023 14.6 0.0 2.1 3 0 0 3 3 3 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Spt20 PF12090.8 CDI85408.1 - 0.17 11.5 41.3 0.038 13.6 9.0 3.6 4 0 0 4 4 4 0 Spt20 family PRIMA1 PF16101.5 CDI85408.1 - 0.95 9.5 15.2 0.38 10.8 0.5 3.9 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 Apt1 PF10351.9 CDI85408.1 - 1 8.2 9.3 0.37 9.6 0.3 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain RskA PF10099.9 CDI85409.1 - 2.1e-06 28.1 16.3 0.0003 21.2 17.0 2.3 1 1 1 2 2 2 1 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI85409.1 - 0.033 13.2 11.0 0.039 12.9 11.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Activator_LAG-3 PF11498.8 CDI85409.1 - 0.035 13.1 30.8 0.056 12.4 30.8 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 MRP-S27 PF10037.9 CDI85409.1 - 0.06 12.2 14.1 0.07 12.0 14.1 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 Rgp1 PF08737.10 CDI85409.1 - 0.12 11.5 16.0 0.13 11.4 16.0 1.1 1 0 0 1 1 1 0 Rgp1 PPP4R2 PF09184.11 CDI85409.1 - 0.16 11.5 19.4 0.2 11.2 19.4 1.2 1 0 0 1 1 1 0 PPP4R2 BBL5 PF07289.11 CDI85409.1 - 0.23 10.5 9.1 0.3 10.1 9.1 1.2 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein DUF4776 PF16003.5 CDI85409.1 - 0.29 10.1 16.2 0.32 10.0 16.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) TFIIA PF03153.13 CDI85409.1 - 0.55 10.2 38.1 0.82 9.6 38.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1682 PF07946.14 CDI85409.1 - 0.63 9.2 14.8 0.85 8.8 14.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) PAT1 PF09770.9 CDI85409.1 - 0.83 7.8 25.7 0.95 7.7 25.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Het-C PF07217.11 CDI85409.1 - 1 7.8 11.5 1.3 7.5 11.5 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C PA26 PF04636.13 CDI85409.1 - 1.2 8.0 14.1 1.9 7.3 14.1 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF3402 PF11882.8 CDI85409.1 - 1.2 8.1 14.5 1.6 7.7 14.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) FemAB PF02388.16 CDI85409.1 - 1.3 7.8 13.4 1.9 7.3 13.4 1.3 1 0 0 1 1 1 0 FemAB family CCDC84 PF14968.6 CDI85409.1 - 1.6 8.3 16.1 2 8.0 16.1 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 FapA PF03961.13 CDI85409.1 - 4.3 5.8 12.1 5.4 5.5 12.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A V_ATPase_I PF01496.19 CDI85409.1 - 4.9 4.9 21.7 6.3 4.6 21.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Endonuc_Holl PF10107.9 CDI85409.1 - 5.6 6.8 11.5 9 6.1 11.5 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Hid1 PF12722.7 CDI85409.1 - 6.1 4.8 22.2 7 4.6 22.2 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4638 PF15472.6 CDI85409.1 - 6.8 6.3 14.7 6 6.5 13.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4638) Folate_carrier PF01770.18 CDI85409.1 - 7.9 5.1 8.0 13 4.3 8.0 1.4 1 0 0 1 1 1 0 Reduced folate carrier DUF5523 PF17661.1 CDI85409.1 - 8 6.1 22.9 11 5.6 22.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) B-block_TFIIIC PF04182.12 CDI85410.1 - 4.6e-07 29.9 0.0 5.8e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_5 PF01022.20 CDI85410.1 - 0.074 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR PF01047.22 CDI85410.1 - 0.18 11.7 0.0 0.31 11.0 0.0 1.3 1 0 0 1 1 1 0 MarR family LZ_Tnp_IS66 PF13007.7 CDI85410.1 - 4.9 8.0 10.3 0.57 11.0 0.6 2.7 3 0 0 3 3 3 0 Transposase C of IS166 homeodomain OPA3 PF07047.12 CDI85411.1 - 0.026 14.3 1.1 0.026 14.3 1.1 8.0 6 1 0 6 6 6 0 Optic atrophy 3 protein (OPA3) DUF4834 PF16118.5 CDI85413.1 - 0.0043 18.0 5.5 0.006 17.5 5.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) DDHD PF02862.17 CDI85413.1 - 0.06 13.5 3.1 0.065 13.4 3.1 1.1 1 0 0 1 1 1 0 DDHD domain FAM176 PF14851.6 CDI85413.1 - 0.062 13.0 4.4 0.1 12.3 4.4 1.3 1 0 0 1 1 1 0 FAM176 family OAD_gamma PF04277.13 CDI85413.1 - 0.063 13.9 0.2 0.063 13.9 0.2 2.5 2 1 0 2 2 1 0 Oxaloacetate decarboxylase, gamma chain Serinc PF03348.15 CDI85413.1 - 0.1 11.5 1.4 0.097 11.6 1.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Folate_carrier PF01770.18 CDI85413.1 - 0.18 10.5 4.7 0.22 10.2 4.7 1.1 1 0 0 1 1 1 0 Reduced folate carrier OATP PF03137.20 CDI85413.1 - 0.19 10.0 3.0 0.23 9.7 3.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family V_ATPase_I PF01496.19 CDI85413.1 - 0.23 9.3 11.0 0.27 9.1 11.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_23 PF13476.6 CDI85413.1 - 0.27 11.7 11.7 0.27 11.7 11.7 1.2 1 0 0 1 1 1 0 AAA domain SID-1_RNA_chan PF13965.6 CDI85413.1 - 0.27 9.6 1.8 0.31 9.4 1.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PEX11 PF05648.14 CDI85413.1 - 0.37 10.2 9.2 6.7 6.1 6.4 2.1 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) DUF4446 PF14584.6 CDI85413.1 - 0.51 10.3 6.7 0.84 9.6 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Exonuc_VII_L PF02601.15 CDI85413.1 - 0.61 9.6 13.8 0.75 9.3 13.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2149 PF09919.9 CDI85413.1 - 0.64 10.3 5.8 1 9.7 5.8 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) CLN3 PF02487.17 CDI85413.1 - 0.66 9.0 6.4 0.92 8.5 6.1 1.3 1 1 0 1 1 1 0 CLN3 protein DUF3464 PF11947.8 CDI85413.1 - 0.67 9.7 5.9 1.1 9.0 4.9 1.8 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Ctr PF04145.15 CDI85413.1 - 1 10.0 5.7 0.99 10.0 4.9 1.5 1 1 0 1 1 1 0 Ctr copper transporter family NEMP PF10225.9 CDI85413.1 - 1.2 8.8 5.2 1.8 8.2 5.2 1.4 1 0 0 1 1 1 0 NEMP family Peroxin-13_N PF04088.13 CDI85413.1 - 1.5 9.1 8.6 2.4 8.4 8.6 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region RskA PF10099.9 CDI85413.1 - 1.8 8.8 22.4 4.1 7.7 22.4 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA PigN PF04987.14 CDI85413.1 - 4.2 6.1 5.7 5.1 5.8 5.7 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) DUF2232 PF09991.9 CDI85413.1 - 4.4 6.4 8.7 6.3 5.9 8.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) EMC3_TMCO1 PF01956.16 CDI85413.1 - 7 6.4 11.3 9.5 5.9 11.3 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like ABC2_membrane_2 PF12679.7 CDI85413.1 - 7.9 5.7 8.2 2.7 7.2 5.1 1.7 1 1 1 2 2 2 0 ABC-2 family transporter protein EIIBC-GUT_N PF03612.14 CDI85413.1 - 9.2 6.0 7.9 1.8 8.2 4.6 1.5 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus RskA PF10099.9 CDI85414.1 - 1.7 8.9 63.1 2.4 8.4 10.5 3.3 2 1 0 2 2 2 0 Anti-sigma-K factor rskA Connexin PF00029.19 CDI85415.1 - 0.46 10.2 5.6 0.49 10.1 5.6 1.1 1 0 0 1 1 1 0 Connexin Phage_Gp23 PF10669.9 CDI85415.1 - 0.47 10.8 9.2 0.53 10.6 9.2 1.1 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) SpoIIP PF07454.11 CDI85415.1 - 0.84 9.0 10.3 0.88 9.0 10.3 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SID-1_RNA_chan PF13965.6 CDI85415.1 - 0.84 8.0 5.8 0.84 8.0 5.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF1840 PF08895.11 CDI85415.1 - 0.9 9.9 10.6 1.1 9.6 10.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) Sec62 PF03839.16 CDI85415.1 - 1.3 8.5 7.4 1.5 8.3 7.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 FAM60A PF15396.6 CDI85415.1 - 1.5 8.8 5.4 1.7 8.6 5.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Pex14_N PF04695.13 CDI85415.1 - 1.5 9.5 17.7 1.7 9.3 17.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CLN3 PF02487.17 CDI85415.1 - 1.9 7.4 8.7 2 7.4 8.7 1.0 1 0 0 1 1 1 0 CLN3 protein EPL1 PF10513.9 CDI85415.1 - 1.9 8.8 11.8 2.3 8.6 11.8 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like Orf78 PF06024.12 CDI85415.1 - 2.5 8.4 9.7 8.7 6.7 9.7 1.8 1 1 0 1 1 1 0 Orf78 (ac78) MTP18 PF10558.9 CDI85415.1 - 3.2 7.7 5.0 3.5 7.5 5.0 1.1 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) MscS_TM PF12794.7 CDI85415.1 - 3.5 6.4 15.7 3.9 6.2 15.7 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Presenilin PF01080.17 CDI85415.1 - 7.9 5.1 11.6 9.1 4.9 11.6 1.1 1 0 0 1 1 1 0 Presenilin Ctr PF04145.15 CDI85415.1 - 8.8 6.9 7.1 9.5 6.8 7.1 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Ctr PF04145.15 CDI85416.1 - 0.0009 19.9 4.5 0.0009 19.9 4.5 1.4 1 1 0 1 1 1 1 Ctr copper transporter family SARAF PF06682.12 CDI85416.1 - 0.0011 18.7 3.5 0.0013 18.4 3.5 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis SRP-alpha_N PF04086.13 CDI85416.1 - 0.0016 18.4 2.3 0.002 18.1 2.3 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal ABC2_membrane_2 PF12679.7 CDI85416.1 - 0.002 17.5 0.3 0.0065 15.8 0.3 1.8 1 1 1 2 2 2 1 ABC-2 family transporter protein Pex14_N PF04695.13 CDI85416.1 - 0.0021 18.8 14.2 0.0021 18.8 14.2 1.8 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4834 PF16118.5 CDI85416.1 - 0.0046 17.9 2.0 0.0046 17.9 2.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) Zip PF02535.22 CDI85416.1 - 0.017 14.3 0.1 0.024 13.9 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 CDI85416.1 - 0.034 14.2 1.3 0.037 14.1 1.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PAF-AH_p_II PF03403.13 CDI85416.1 - 0.035 12.6 0.3 0.046 12.2 0.3 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Presenilin PF01080.17 CDI85416.1 - 0.043 12.6 3.1 0.059 12.1 3.1 1.4 1 0 0 1 1 1 0 Presenilin OATP PF03137.20 CDI85416.1 - 0.081 11.2 0.5 0.1 10.8 0.5 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Serinc PF03348.15 CDI85416.1 - 0.14 11.1 3.4 0.16 10.9 2.7 1.7 1 1 0 1 1 1 0 Serine incorporator (Serinc) Hamartin PF04388.12 CDI85416.1 - 0.24 10.0 10.9 0.32 9.6 10.9 1.1 1 0 0 1 1 1 0 Hamartin protein DUF4366 PF14283.6 CDI85416.1 - 0.4 10.7 2.6 1.3 9.1 1.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Spc7_N PF15402.6 CDI85416.1 - 0.45 8.7 6.9 0.58 8.3 6.9 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF778 PF05608.12 CDI85416.1 - 1.1 9.6 7.9 1.8 8.9 7.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF778) RskA PF10099.9 CDI85416.1 - 1.5 9.1 30.3 0.088 13.1 11.7 2.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA RR_TM4-6 PF06459.12 CDI85416.1 - 2.6 7.8 6.4 3.3 7.4 6.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 CDI85416.1 - 3.4 6.5 10.7 4.9 6.0 10.7 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3464 PF11947.8 CDI85416.1 - 5.8 6.7 6.6 11 5.7 6.6 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 PAT1 PF09770.9 CDI85416.1 - 6 5.0 23.5 7.2 4.7 23.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1600 PF07667.11 CDI85417.1 - 0.33 11.2 4.1 0.69 10.1 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1600) DUF4834 PF16118.5 CDI85417.1 - 0.46 11.5 0.9 2.2 9.3 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Cation_ATPase_C PF00689.21 CDI85418.1 - 1.4e-52 178.1 1.8 3.1e-52 176.9 1.8 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CDI85418.1 - 9.9e-51 171.8 2.5 6.3e-50 169.2 0.3 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CDI85418.1 - 1.9e-20 74.1 3.0 9.6e-18 65.2 0.1 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDI85418.1 - 5.4e-20 71.3 0.0 1.1e-19 70.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CDI85418.1 - 3.1e-19 68.4 0.0 1.6e-18 66.1 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CDI85418.1 - 1.4e-05 24.9 0.5 7.5e-05 22.6 0.5 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDI85418.1 - 0.002 18.6 0.0 0.0077 16.7 0.0 2.2 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase TMEM208_SND2 PF05620.11 CDI85418.1 - 3.7 7.3 4.8 6.1 6.6 0.2 2.5 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 PspB PF06667.12 CDI85419.1 - 0.057 13.5 0.2 0.092 12.8 0.2 1.3 1 0 0 1 1 1 0 Phage shock protein B Tim54 PF11711.8 CDI85419.1 - 0.085 11.6 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SCIMP PF15050.6 CDI85419.1 - 0.12 12.9 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 SCIMP protein DUF4359 PF14271.6 CDI85419.1 - 0.18 12.6 0.4 6.7 7.5 0.0 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4359) RAP1 PF07218.11 CDI85421.1 - 1.2 7.3 5.0 1.2 7.4 5.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) BAF1_ABF1 PF04684.13 CDI85421.1 - 1.4 7.8 24.4 1.6 7.7 24.4 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor HAUS6_N PF14661.6 CDI85421.1 - 2.6 7.6 23.2 2.7 7.5 23.2 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus TFIIA PF03153.13 CDI85421.1 - 6.5 6.6 45.9 8.4 6.3 45.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CCSAP PF15748.5 CDI85421.1 - 8.3 6.5 35.2 10 6.2 35.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF2722 PF10846.8 CDI85422.1 - 0.00022 20.3 1.6 0.00022 20.3 1.6 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI85422.1 - 0.0014 18.6 0.6 0.0014 18.6 0.6 3.8 3 1 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI85422.1 - 0.011 15.4 11.4 0.011 15.4 11.4 2.3 2 0 0 2 2 2 0 Spt20 family Presenilin PF01080.17 CDI85422.1 - 2 7.1 6.4 0.81 8.4 0.4 2.3 2 0 0 2 2 2 0 Presenilin RAB3GAP2_N PF14655.6 CDI85422.1 - 4.1 6.5 13.3 0.33 10.2 2.9 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Pap_E4 PF02711.14 CDI85424.1 - 0.062 14.3 12.6 2.1 9.3 5.7 2.4 2 0 0 2 2 2 0 E4 protein DUF3385 PF11865.8 CDI85424.1 - 0.15 12.0 9.8 0.091 12.7 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) Tau95_N PF17682.1 CDI85424.1 - 0.16 12.2 8.8 0.52 10.5 0.4 2.2 2 0 0 2 2 2 0 Tau95 Triple barrel domain Connexin PF00029.19 CDI85424.1 - 0.26 11.0 10.6 1.8 8.3 1.9 2.1 2 0 0 2 2 2 0 Connexin RR_TM4-6 PF06459.12 CDI85424.1 - 2.9 7.7 22.1 3.4 7.4 3.2 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 SART-1 PF03343.13 CDI85424.1 - 5.3 5.5 23.1 7.5 5.0 23.1 1.2 1 0 0 1 1 1 0 SART-1 family RskA PF10099.9 CDI85425.1 - 0.014 15.7 0.9 0.014 15.7 0.9 3.3 1 1 2 3 3 3 0 Anti-sigma-K factor rskA MCR_alpha PF02249.17 CDI85425.1 - 4.2 7.8 8.1 2.5 8.5 3.0 2.4 2 0 0 2 2 2 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain AAA_23 PF13476.6 CDI85425.1 - 4.4 7.8 30.5 0.38 11.2 9.2 2.3 2 0 0 2 2 2 0 AAA domain DUF3123 PF11321.8 CDI85425.1 - 5.8 7.6 9.4 3 8.6 3.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) CPSF100_C PF13299.6 CDI85426.1 - 0.11 12.6 2.5 0.13 12.5 2.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RPN2_C PF18004.1 CDI85426.1 - 0.13 12.2 4.8 0.13 12.1 4.8 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain TRAP_alpha PF03896.16 CDI85426.1 - 0.25 10.5 3.5 0.22 10.7 3.5 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.6 CDI85426.1 - 0.37 10.4 5.3 0.4 10.3 5.3 1.2 1 0 0 1 1 1 0 FAM176 family Ribosomal_60s PF00428.19 CDI85426.1 - 0.83 10.3 16.3 1.2 9.8 16.3 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Merozoite_SPAM PF07133.11 CDI85426.1 - 1 9.3 18.9 1.1 9.2 18.9 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DUF4746 PF15928.5 CDI85426.1 - 1.2 8.5 9.2 1.1 8.7 9.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF2457 PF10446.9 CDI85426.1 - 1.4 8.0 11.9 1.3 8.1 11.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 CDI85426.1 - 1.5 8.1 7.6 1.7 7.9 7.6 1.0 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 CDI85426.1 - 1.9 8.2 8.3 2 8.1 8.3 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 CDI85426.1 - 2 6.4 11.9 1.9 6.5 11.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 CDI85426.1 - 3.1 5.9 10.8 3.1 5.9 10.8 1.0 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.13 CDI85426.1 - 3.6 6.5 14.2 3.7 6.4 14.2 1.0 1 0 0 1 1 1 0 Paf1 Radial_spoke PF04712.12 CDI85426.1 - 3.9 6.3 13.2 4.1 6.2 13.2 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein CDC45 PF02724.14 CDI85426.1 - 4.2 5.6 8.4 4.1 5.6 8.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Cytomega_UL84 PF06284.11 CDI85426.1 - 8.3 4.7 7.6 7 5.0 7.6 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein RIFIN PF02009.16 CDI85427.1 - 2.6 7.8 9.4 3.2 7.6 9.4 1.1 1 0 0 1 1 1 0 Rifin SPX PF03105.19 CDI85427.1 - 8 6.3 36.2 12 5.7 36.2 1.3 1 0 0 1 1 1 0 SPX domain Hus1 PF04005.12 CDI85428.1 - 0.058 12.5 0.0 0.065 12.3 0.0 1.2 1 0 0 1 1 1 0 Hus1-like protein GCP_C_terminal PF04130.13 CDI85429.1 - 4.6e-17 62.5 33.7 4.6e-17 62.5 33.7 4.0 3 1 0 3 3 3 1 Gamma tubulin complex component C-terminal Ribosomal_60s PF00428.19 CDI85429.1 - 0.0039 17.7 13.2 0.0039 17.7 13.2 12.2 12 1 1 13 13 13 3 60s Acidic ribosomal protein Sin_N PF04801.13 CDI85429.1 - 0.22 10.7 0.0 0.22 10.7 0.0 7.8 6 2 0 7 7 7 0 Sin-like protein conserved region DUF3854 PF12965.7 CDI85430.1 - 2.1 8.3 6.3 1.1 9.3 4.5 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3854) NAM-associated PF14303.6 CDI85430.1 - 2.8 8.6 21.0 3.5 8.3 21.0 1.1 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain SLC12 PF03522.15 CDI85430.1 - 7.8 5.4 11.5 9.1 5.2 11.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Drc1-Sld2 PF11719.8 CDI85430.1 - 7.9 5.9 26.9 8.9 5.7 26.9 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein DUF4834 PF16118.5 CDI85431.1 - 0.022 15.7 4.3 0.022 15.7 4.3 4.7 3 2 0 3 3 3 0 Domain of unknown function (DUF4834) EPL1 PF10513.9 CDI85432.1 - 0.16 12.3 3.2 0.74 10.2 0.3 2.6 2 0 0 2 2 2 0 Enhancer of polycomb-like Activator_LAG-3 PF11498.8 CDI85432.1 - 0.26 10.2 31.5 0.11 11.4 17.7 2.6 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI85432.1 - 0.35 10.5 34.9 0.073 12.7 19.7 2.5 2 0 0 2 2 2 0 Spt20 family Clr2 PF10383.9 CDI85432.1 - 0.57 11.0 5.2 0.61 10.9 0.6 3.1 2 0 0 2 2 2 0 Transcription-silencing protein Clr2 Rxt3 PF08642.10 CDI85432.1 - 6.8 7.5 6.4 11 6.8 2.2 2.7 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 MarC PF01914.17 CDI85432.1 - 8.7 5.7 7.5 1.3 8.3 0.7 2.3 2 0 0 2 2 2 0 MarC family integral membrane protein PA26 PF04636.13 CDI85432.1 - 8.8 5.1 8.9 1.3 7.9 2.6 2.2 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) PRP38_assoc PF12871.7 CDI85433.1 - 0.1 13.2 79.9 2.7e+03 -1.0 79.9 2.1 1 1 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Macoilin PF09726.9 CDI85433.1 - 0.2 10.2 19.4 0.22 10.1 19.4 1.1 1 0 0 1 1 1 0 Macoilin family RSRP PF17069.5 CDI85433.1 - 0.7 9.4 43.7 1 8.9 43.7 1.3 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 SR-25 PF10500.9 CDI85433.1 - 0.91 9.1 55.4 0.62 9.6 52.8 1.7 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein SRC-1 PF08832.10 CDI85433.1 - 1.4 10.1 18.2 2.1 9.5 18.2 1.3 1 0 0 1 1 1 0 Steroid receptor coactivator Rtf2 PF04641.12 CDI85433.1 - 1.8 7.9 17.4 2.2 7.6 17.4 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger RR_TM4-6 PF06459.12 CDI85434.1 - 0.47 10.2 15.1 4.1 7.2 10.5 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 FAM176 PF14851.6 CDI85434.1 - 0.56 9.8 10.7 6.2 6.5 7.4 2.3 2 0 0 2 2 2 0 FAM176 family Connexin PF00029.19 CDI85434.1 - 0.85 9.3 13.2 5.9 6.6 9.3 2.1 2 0 0 2 2 2 0 Connexin SpoIIP PF07454.11 CDI85434.1 - 3.7 6.9 19.3 0.78 9.1 8.8 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) PIP5K PF01504.18 CDI85434.1 - 6 6.0 15.1 7.6 5.7 0.1 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase CLN3 PF02487.17 CDI85434.1 - 6.8 5.6 15.9 4.3 6.3 0.2 2.1 2 0 0 2 2 2 0 CLN3 protein Ribosomal_60s PF00428.19 CDI85434.1 - 7.5 7.2 34.1 2.4 8.8 11.5 2.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein eIF-3_zeta PF05091.12 CDI85434.1 - 8.8 5.2 25.3 1.3 7.9 0.4 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Nop14 PF04147.12 CDI85435.1 - 1.2 7.3 24.6 1.3 7.1 24.6 1.0 1 0 0 1 1 1 0 Nop14-like family Rtf2 PF04641.12 CDI85435.1 - 6.6 6.0 26.8 7.1 5.9 26.8 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger zf-U1 PF06220.12 CDI85436.1 - 0.00046 19.9 0.5 0.00046 19.9 0.5 2.4 2 0 0 2 2 2 1 U1 zinc finger WW PF00397.26 CDI85436.1 - 0.016 15.3 1.0 0.047 13.8 0.1 2.2 2 0 0 2 2 2 0 WW domain Ribosomal_S2 PF00318.20 CDI85436.1 - 0.024 13.9 1.9 0.052 12.8 1.9 1.5 1 0 0 1 1 1 0 Ribosomal protein S2 Peptidase_M24 PF00557.24 CDI85437.1 - 2.6e-36 125.3 0.0 4.8e-36 124.4 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 CDI85437.1 - 8.4e-34 117.0 0.0 2e-32 112.5 0.0 2.9 3 1 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 CDI85437.1 - 7.1e-22 77.3 0.1 7.1e-22 77.3 0.1 2.4 4 0 0 4 4 4 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 CDI85437.1 - 7.9e-20 71.9 0.1 8.6e-15 55.6 0.0 2.8 3 0 0 3 3 3 2 Creatinase/Prolidase N-terminal domain EGF_3 PF12947.7 CDI85438.1 - 0.035 14.3 38.8 1.2 9.4 2.4 7.8 7 0 0 7 7 7 0 EGF domain ASH PF15780.5 CDI85439.1 - 1e-61 205.2 25.6 3.5e-08 33.5 0.0 20.7 20 1 1 21 21 21 14 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 CDI85439.1 - 1.2e-20 73.6 3.0 0.018 15.2 0.0 14.0 17 0 0 17 17 17 3 Flagellar-associated PapD-like DUF1573 PF07610.11 CDI85439.1 - 9.5e-14 51.2 0.0 4.2 7.5 0.0 13.6 15 2 0 15 15 15 2 Protein of unknown function (DUF1573) Motile_Sperm PF00635.26 CDI85439.1 - 2.6e-13 49.7 0.4 0.35 10.7 0.0 10.2 12 0 0 12 12 12 2 MSP (Major sperm protein) domain TMEM131_like PF12371.8 CDI85439.1 - 1.6e-06 28.3 11.8 7 7.0 0.1 10.8 13 0 0 13 13 13 1 Transmembrane protein 131-like FixG_C PF11614.8 CDI85439.1 - 4.6e-05 23.6 0.1 11 6.3 0.0 6.6 7 0 0 7 7 7 1 IG-like fold at C-terminal of FixG, putative oxidoreductase fn3_5 PF06280.12 CDI85439.1 - 0.00094 19.9 4.2 6.4 7.5 0.0 7.6 8 1 0 8 8 8 1 Fn3-like domain MYCBPAP PF14646.6 CDI85439.1 - 0.0011 18.1 0.8 48 2.7 0.0 6.4 6 1 1 7 7 7 0 MYCBP-associated protein family ATP-synt_C PF00137.21 CDI85440.1 - 1.3e-28 99.1 24.8 4.7e-16 58.9 10.6 3.1 3 0 0 3 3 3 2 ATP synthase subunit C TraL PF07178.11 CDI85440.1 - 7.2 7.2 6.2 2.1 8.9 0.1 2.7 2 2 0 2 2 2 0 TraL protein IMCp PF12314.8 CDI85441.1 - 7.4e-23 80.7 18.7 7.4e-23 80.7 18.7 3.8 1 1 2 3 3 3 3 Inner membrane complex protein ParA PF10609.9 CDI85442.1 - 4.2e-66 222.9 0.0 7.9e-45 153.2 0.0 2.1 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase FeS_assembly_P PF01883.19 CDI85442.1 - 1.6e-14 53.8 0.0 5.3e-14 52.1 0.0 1.9 2 0 0 2 2 2 1 Iron-sulfur cluster assembly protein CbiA PF01656.23 CDI85442.1 - 3.8e-10 39.9 0.0 5.8e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDI85442.1 - 7.4e-07 29.2 0.2 3.7e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF971 PF06155.12 CDI85442.1 - 2.9e-06 27.8 0.0 5.9e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF971) MipZ PF09140.11 CDI85442.1 - 3.3e-06 26.6 0.0 5.9e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 CDI85442.1 - 0.002 17.3 0.6 0.19 10.8 0.1 2.2 2 0 0 2 2 2 2 Anion-transporting ATPase VirC1 PF07015.11 CDI85442.1 - 0.0069 15.7 0.1 0.012 15.0 0.1 1.3 1 0 0 1 1 1 1 VirC1 protein APS_kinase PF01583.20 CDI85442.1 - 0.042 13.7 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase CLP1_P PF16575.5 CDI85442.1 - 0.13 12.0 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MeaB PF03308.16 CDI85442.1 - 0.15 11.0 0.1 0.26 10.3 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF1574 PF07611.11 CDI85443.1 - 0.0086 15.4 1.9 0.012 15.0 1.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1574) V_ATPase_I PF01496.19 CDI85443.1 - 0.025 12.5 6.5 0.028 12.3 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NTP_transf_5 PF14907.6 CDI85443.1 - 0.15 11.7 0.1 0.15 11.7 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised nucleotidyltransferase Sec20 PF03908.13 CDI85443.1 - 0.43 10.5 4.1 0.86 9.6 4.1 1.4 1 0 0 1 1 1 0 Sec20 YabA PF06156.13 CDI85443.1 - 1.3 9.7 12.4 0.59 10.8 8.7 2.1 2 0 0 2 2 2 0 Initiation control protein YabA malic PF00390.19 CDI85444.1 - 0.13 12.0 0.0 13 5.5 0.0 2.2 2 0 0 2 2 2 0 Malic enzyme, N-terminal domain Utp14 PF04615.13 CDI85446.1 - 0.064 11.8 34.8 0.073 11.6 34.8 1.1 1 0 0 1 1 1 0 Utp14 protein DUF966 PF06136.13 CDI85446.1 - 0.12 12.1 34.0 0.15 11.8 34.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF572 PF04502.13 CDI85446.1 - 0.21 11.1 29.8 0.27 10.8 29.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) GREB1 PF15782.5 CDI85446.1 - 0.66 7.0 36.2 0.8 6.7 36.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2722 PF10846.8 CDI85447.1 - 0.0089 15.0 14.3 0.0089 15.0 14.3 4.1 2 1 2 4 4 4 1 Protein of unknown function (DUF2722) CDC45 PF02724.14 CDI85447.1 - 1.4 7.1 31.9 0.14 10.4 25.0 2.1 2 0 0 2 2 2 0 CDC45-like protein Apt1 PF10351.9 CDI85447.1 - 2.6 6.8 33.2 1.9 7.3 3.3 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain AF-4 PF05110.13 CDI85447.1 - 3.2 5.7 56.6 0.46 8.5 37.8 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein DUF883 PF05957.13 CDI85449.1 - 0.0014 19.2 27.1 1 10.0 13.6 3.1 1 1 2 3 3 3 3 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 CDI85449.1 - 0.0028 18.2 32.4 0.021 15.3 1.5 3.3 1 1 1 2 2 2 1 YtxH-like protein Apolipoprotein PF01442.18 CDI85449.1 - 0.014 15.3 18.4 0.75 9.6 13.2 2.1 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Dehydrin PF00257.19 CDI85450.1 - 0.00024 21.7 5.5 0.00024 21.7 5.5 12.5 6 5 3 11 11 11 2 Dehydrin RAP1 PF07218.11 CDI85451.1 - 1.9 6.7 3.9 3 6.0 3.9 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CwfJ_C_1 PF04677.15 CDI85452.1 - 4.1e-26 91.2 0.0 8.1e-26 90.3 0.0 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 CDI85452.1 - 8.9e-07 29.7 0.0 8.9e-07 29.7 0.0 3.1 3 0 0 3 3 3 1 Protein similar to CwfJ C-terminus 2 RRM_1 PF00076.22 CDI85452.1 - 2.8e-06 27.0 0.0 8.3e-06 25.5 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HNOBA PF07701.14 CDI85452.1 - 0.31 10.4 2.9 0.77 9.2 2.9 1.6 1 1 0 1 1 1 0 Heme NO binding associated Peptidase_S49_N PF08496.10 CDI85452.1 - 1.5 8.9 5.6 6.5 6.8 0.9 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Spt20 PF12090.8 CDI85452.1 - 6.7 6.2 45.9 1.6 8.3 21.0 3.9 4 0 0 4 4 4 0 Spt20 family U1snRNP70_N PF12220.8 CDI85452.1 - 8.3 7.1 14.2 8.4 7.1 2.2 3.4 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Ank_2 PF12796.7 CDI85453.1 - 8.7e-23 80.7 0.4 2.8e-07 31.0 0.4 3.5 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI85453.1 - 1.8e-22 79.4 1.5 1.1e-07 32.3 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 CDI85453.1 - 1e-18 66.9 7.7 0.00084 19.7 0.1 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 CDI85453.1 - 8.7e-17 59.5 0.5 0.088 13.4 0.0 5.5 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 CDI85453.1 - 2.1e-09 37.5 3.0 0.039 14.3 0.1 4.6 3 2 2 5 5 5 5 Ankyrin repeats (many copies) TMEM51 PF15345.6 CDI85454.1 - 0.00063 19.7 10.8 0.00077 19.4 10.8 1.0 1 0 0 1 1 1 1 Transmembrane protein 51 DUF2615 PF11027.8 CDI85454.1 - 0.0018 18.4 2.3 0.0024 18.0 2.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) ESM4 PF15952.5 CDI85454.1 - 0.0038 17.7 12.5 0.0046 17.4 12.5 1.2 1 0 0 1 1 1 1 Enhancer of split M4 family Spt20 PF12090.8 CDI85454.1 - 0.0093 15.6 24.5 0.011 15.4 24.5 1.2 1 0 0 1 1 1 1 Spt20 family YjeJ PF15922.5 CDI85454.1 - 0.01 15.1 6.4 0.014 14.6 6.4 1.2 1 0 0 1 1 1 0 YjeJ-like CSG2 PF16965.5 CDI85454.1 - 0.04 12.9 7.1 0.044 12.7 7.1 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator EPL1 PF10513.9 CDI85454.1 - 0.05 14.0 12.4 0.065 13.6 12.4 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like ABC2_membrane_2 PF12679.7 CDI85454.1 - 0.079 12.2 1.4 0.092 12.0 1.4 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein PPP4R2 PF09184.11 CDI85454.1 - 0.097 12.2 9.9 0.12 11.9 9.9 1.1 1 0 0 1 1 1 0 PPP4R2 CCSAP PF15748.5 CDI85454.1 - 0.11 12.6 15.4 0.18 12.0 15.4 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Serinc PF03348.15 CDI85454.1 - 0.12 11.3 8.0 0.14 11.0 8.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF572 PF04502.13 CDI85454.1 - 0.13 11.9 10.9 0.15 11.6 10.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) FHIPEP PF00771.20 CDI85454.1 - 0.13 10.7 4.6 0.15 10.5 4.6 1.0 1 0 0 1 1 1 0 FHIPEP family Velvet PF11754.8 CDI85454.1 - 0.13 12.2 13.2 0.16 11.9 13.2 1.0 1 0 0 1 1 1 0 Velvet factor Presenilin PF01080.17 CDI85454.1 - 0.14 10.9 17.6 0.17 10.6 17.6 1.0 1 0 0 1 1 1 0 Presenilin DUF4366 PF14283.6 CDI85454.1 - 0.14 12.2 4.5 0.18 11.8 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Spem1 PF15670.5 CDI85454.1 - 0.15 11.7 14.0 0.15 11.6 14.0 1.0 1 0 0 1 1 1 0 Spermatid maturation protein 1 RskA PF10099.9 CDI85454.1 - 0.16 12.2 2.8 0.26 11.6 2.8 1.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA FAM176 PF14851.6 CDI85454.1 - 0.2 11.3 9.3 0.12 12.1 7.2 1.6 1 1 1 2 2 2 0 FAM176 family SID-1_RNA_chan PF13965.6 CDI85454.1 - 0.23 9.8 6.1 0.27 9.6 6.1 1.2 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 eIF-3_zeta PF05091.12 CDI85454.1 - 0.26 10.2 14.0 0.3 10.0 14.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4175 PF13779.6 CDI85454.1 - 0.28 9.1 19.7 0.3 9.0 19.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) V_ATPase_I PF01496.19 CDI85454.1 - 0.28 9.0 12.7 0.31 8.9 12.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TFIIA PF03153.13 CDI85454.1 - 0.33 10.9 24.5 0.4 10.6 24.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PBP_sp32 PF07222.12 CDI85454.1 - 0.35 10.3 16.4 0.43 10.0 16.4 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Ctr PF04145.15 CDI85454.1 - 0.42 11.2 0.1 0.42 11.2 0.1 2.0 1 1 1 2 2 1 0 Ctr copper transporter family GRP PF07172.11 CDI85454.1 - 0.7 10.6 4.5 0.67 10.7 3.1 1.7 1 1 0 1 1 1 0 Glycine rich protein family Suf PF05843.14 CDI85454.1 - 0.71 9.8 13.2 0.95 9.4 13.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RBP_receptor PF14752.6 CDI85454.1 - 0.81 8.2 5.1 0.84 8.1 5.1 1.2 1 0 0 1 1 1 0 Retinol binding protein receptor Fe_bilin_red PF05996.12 CDI85454.1 - 1 9.0 12.2 1.2 8.8 12.2 1.1 1 0 0 1 1 1 0 Ferredoxin-dependent bilin reductase FPN1 PF06963.12 CDI85454.1 - 1.1 7.8 5.8 1.3 7.5 5.8 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) MMR1 PF08505.10 CDI85454.1 - 1.7 8.8 19.0 2.2 8.5 19.0 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SARAF PF06682.12 CDI85454.1 - 1.9 8.0 13.1 4 7.0 13.1 1.5 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Corona_nucleoca PF00937.18 CDI85454.1 - 2.1 7.3 14.7 2.5 7.0 14.7 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein XK-related PF09815.9 CDI85454.1 - 2.2 7.3 4.7 2.4 7.1 4.7 1.2 1 0 0 1 1 1 0 XK-related protein SOBP PF15279.6 CDI85454.1 - 2.2 8.8 13.7 2.7 8.5 13.7 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Neur_chan_memb PF02932.16 CDI85454.1 - 2.2 8.3 9.8 2.6 8.0 9.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Secretin_N_2 PF07655.13 CDI85454.1 - 2.5 8.7 14.1 0.99 10.0 4.4 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain Rgp1 PF08737.10 CDI85454.1 - 3 6.9 16.8 3.5 6.7 16.8 1.0 1 0 0 1 1 1 0 Rgp1 CLN3 PF02487.17 CDI85454.1 - 3.2 6.7 10.2 2.3 7.2 9.2 1.2 1 1 0 1 1 1 0 CLN3 protein SprA-related PF12118.8 CDI85454.1 - 3.3 6.8 22.1 4.5 6.3 22.1 1.2 1 0 0 1 1 1 0 SprA-related family DUF4703 PF15775.5 CDI85454.1 - 3.7 7.3 13.6 4.4 7.1 13.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4703) Zip PF02535.22 CDI85454.1 - 4.3 6.5 9.9 5.6 6.1 9.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3381 PF11861.8 CDI85454.1 - 4.3 7.1 17.6 0.48 10.2 13.6 1.4 2 0 0 2 2 1 0 Domain of unknown function (DUF3381) DUF4746 PF15928.5 CDI85454.1 - 4.4 6.6 14.3 6.4 6.1 14.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FYDLN_acid PF09538.10 CDI85454.1 - 5.6 7.7 11.2 0.51 11.0 5.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) PBP1_TM PF14812.6 CDI85454.1 - 6.4 7.2 11.9 24 5.4 0.0 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SHR3_chaperone PF08229.11 CDI85454.1 - 6.8 5.6 10.1 7.7 5.4 10.1 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 Peptidase_S64 PF08192.11 CDI85454.1 - 6.9 5.0 14.1 8.4 4.7 14.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF3959 PF13105.6 CDI85454.1 - 9.7 5.6 7.8 11 5.4 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) Activator_LAG-3 PF11498.8 CDI85456.1 - 0.001 18.1 32.0 0.0013 17.8 32.0 1.1 1 0 0 1 1 1 1 Transcriptional activator LAG-3 CCSAP PF15748.5 CDI85456.1 - 0.0096 16.1 20.5 0.013 15.7 20.5 1.2 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated POP1 PF06978.11 CDI85456.1 - 0.01 15.8 11.9 0.014 15.4 11.9 1.1 1 0 0 1 1 1 0 Ribonucleases P/MRP protein subunit POP1 MMR1 PF08505.10 CDI85456.1 - 0.075 13.3 20.3 0.085 13.1 20.3 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Velvet PF11754.8 CDI85456.1 - 0.12 12.3 13.7 0.16 11.9 13.7 1.2 1 0 0 1 1 1 0 Velvet factor Asp-B-Hydro_N PF05279.11 CDI85456.1 - 0.13 12.3 16.3 0.15 12.1 16.3 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Dsh_C PF12316.8 CDI85456.1 - 0.14 12.6 16.6 0.21 12.0 16.6 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Endostatin PF06482.11 CDI85456.1 - 0.14 11.6 12.9 0.16 11.4 12.9 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF2992 PF11208.8 CDI85456.1 - 0.34 11.2 16.9 0.55 10.5 16.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) eIF-3_zeta PF05091.12 CDI85456.1 - 0.45 9.4 15.8 0.49 9.3 15.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CNDH2_C PF16858.5 CDI85456.1 - 0.6 9.9 17.6 0.68 9.8 17.6 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PAT1 PF09770.9 CDI85456.1 - 0.81 7.9 28.2 0.92 7.7 28.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Rgp1 PF08737.10 CDI85456.1 - 1.2 8.2 14.4 1.4 8.0 14.4 1.0 1 0 0 1 1 1 0 Rgp1 Presenilin PF01080.17 CDI85456.1 - 1.2 7.8 19.5 1.6 7.4 19.5 1.3 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 CDI85456.1 - 1.5 8.6 7.0 1.8 8.2 7.0 1.4 1 0 0 1 1 1 0 Connexin SOBP PF15279.6 CDI85456.1 - 1.7 9.2 15.0 2 8.9 15.0 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein V_ATPase_I PF01496.19 CDI85456.1 - 2.1 6.2 11.0 2.1 6.2 11.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 CDI85456.1 - 2.6 6.2 15.1 2.9 6.1 15.1 1.1 1 0 0 1 1 1 0 CDC45-like protein PA26 PF04636.13 CDI85456.1 - 2.7 6.8 12.5 3.3 6.5 12.5 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Peptidase_S15 PF02129.18 CDI85456.1 - 2.8 7.5 12.5 3.9 7.0 12.5 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) SLC12 PF03522.15 CDI85456.1 - 3.3 6.6 15.5 3.7 6.5 15.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI85456.1 - 3.8 7.5 13.6 5 7.1 13.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Med15 PF09606.10 CDI85456.1 - 3.9 6.0 36.9 4.6 5.8 36.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Hid1 PF12722.7 CDI85456.1 - 4.9 5.2 21.2 5.7 4.9 21.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ABC2_membrane_2 PF12679.7 CDI85456.1 - 5.4 6.2 7.1 8.1 5.6 7.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein RR_TM4-6 PF06459.12 CDI85456.1 - 5.5 6.7 18.3 8.5 6.1 18.3 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 CDI85456.1 - 5.6 5.7 11.8 6.2 5.5 11.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4746 PF15928.5 CDI85456.1 - 6.9 6.0 12.2 8.5 5.7 12.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF966 PF06136.13 CDI85456.1 - 7.4 6.2 19.2 11 5.6 19.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Zip PF02535.22 CDI85456.1 - 8.2 5.5 9.1 10 5.2 9.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter AAA_23 PF13476.6 CDI85456.1 - 8.3 6.8 17.6 11 6.4 17.6 1.2 1 0 0 1 1 1 0 AAA domain Membralin PF09746.9 CDI85456.1 - 9.3 5.2 9.0 9.8 5.1 9.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein Pex14_N PF04695.13 CDI85456.1 - 9.3 6.9 31.1 19 5.9 31.1 1.5 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3584 PF12128.8 CDI85456.1 - 9.3 3.6 30.5 10 3.5 30.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spt20 PF12090.8 CDI85458.1 - 0.0012 18.5 20.2 0.0013 18.4 20.2 1.1 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI85458.1 - 0.0028 16.7 15.0 0.003 16.6 15.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Med15 PF09606.10 CDI85458.1 - 0.018 13.8 19.5 0.02 13.6 19.5 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI85458.1 - 0.034 14.2 32.4 0.042 13.8 32.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 CDI85458.1 - 0.043 12.9 11.2 0.045 12.8 11.2 1.1 1 0 0 1 1 1 0 Drosophila roughex protein DUF4820 PF16091.5 CDI85458.1 - 0.092 12.1 3.8 0.1 11.9 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Suf PF05843.14 CDI85458.1 - 0.13 12.3 9.7 0.13 12.2 9.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Activator_LAG-3 PF11498.8 CDI85458.1 - 0.13 11.3 28.9 0.15 11.0 28.9 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TERB2 PF15101.6 CDI85458.1 - 0.14 12.2 9.0 0.15 12.1 9.0 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Neur_chan_memb PF02932.16 CDI85458.1 - 0.26 11.3 8.0 0.3 11.1 8.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RAB3GAP2_N PF14655.6 CDI85458.1 - 0.27 10.5 7.3 0.28 10.4 7.3 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus MAT1 PF06391.13 CDI85458.1 - 0.28 11.0 10.4 0.32 10.8 10.4 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF4834 PF16118.5 CDI85458.1 - 0.43 11.6 7.8 0.58 11.2 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DivIC PF04977.15 CDI85458.1 - 0.49 10.2 13.1 0.78 9.6 13.1 1.3 1 0 0 1 1 1 0 Septum formation initiator Velvet PF11754.8 CDI85458.1 - 0.54 10.2 9.1 0.57 10.1 9.1 1.1 1 0 0 1 1 1 0 Velvet factor CLN3 PF02487.17 CDI85458.1 - 0.55 9.2 3.7 0.61 9.1 3.7 1.2 1 0 0 1 1 1 0 CLN3 protein EPL1 PF10513.9 CDI85458.1 - 0.58 10.5 7.1 0.67 10.3 7.1 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like UPF0560 PF10577.9 CDI85458.1 - 0.7 8.3 14.1 0.76 8.2 14.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF1980 PF09323.10 CDI85458.1 - 0.74 9.7 4.6 0.92 9.4 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Coilin_N PF15862.5 CDI85458.1 - 0.83 9.5 9.2 1.2 8.9 9.2 1.2 1 0 0 1 1 1 0 Coilin N-terminus Baculo_PP31 PF05311.11 CDI85458.1 - 1 8.8 5.5 1.1 8.7 5.5 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DDHD PF02862.17 CDI85458.1 - 1.2 9.2 8.0 1.4 9.1 8.0 1.2 1 0 0 1 1 1 0 DDHD domain RLL PF10036.9 CDI85458.1 - 1.3 8.8 18.2 1.6 8.5 18.2 1.1 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein Presenilin PF01080.17 CDI85458.1 - 1.7 7.3 11.0 1.9 7.2 11.0 1.1 1 0 0 1 1 1 0 Presenilin DUF2232 PF09991.9 CDI85458.1 - 2 7.5 4.6 2.3 7.3 4.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Ndc1_Nup PF09531.10 CDI85458.1 - 2.9 6.5 12.5 3 6.4 12.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pex14_N PF04695.13 CDI85458.1 - 6 7.5 26.4 8.7 7.0 26.4 1.3 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SWI-SNF_Ssr4 PF08549.10 CDI85458.1 - 7.7 5.0 22.5 9.2 4.8 22.5 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) SRP-alpha_N PF04086.13 CDI85458.1 - 9.2 6.1 13.8 10 5.9 13.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal EMP24_GP25L PF01105.24 CDI85460.1 - 3.6e-30 105.2 0.0 4.4e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SWI-SNF_Ssr4 PF08549.10 CDI85461.1 - 0.29 9.7 2.8 0.37 9.4 2.8 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) FSA_C PF10479.9 CDI85461.1 - 2.3 6.2 6.4 3.1 5.8 6.4 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus EXS PF03124.14 CDI85462.1 - 8.7e-31 107.5 1.9 1.1e-30 107.1 1.9 1.2 1 0 0 1 1 1 1 EXS family SDH_alpha PF03313.15 CDI85462.1 - 0.1 12.2 6.1 0.15 11.7 6.1 1.2 1 0 0 1 1 1 0 Serine dehydratase alpha chain Presenilin PF01080.17 CDI85463.1 - 0.012 14.4 9.8 0.014 14.2 9.8 1.1 1 0 0 1 1 1 0 Presenilin DUF3824 PF12868.7 CDI85463.1 - 0.043 14.5 0.7 0.043 14.5 0.7 2.9 3 0 0 3 3 3 0 Domain of unknwon function (DUF3824) Ribosomal_60s PF00428.19 CDI85463.1 - 0.14 12.8 13.0 2.1 9.0 4.4 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein DDRGK PF09756.9 CDI85463.1 - 0.24 10.9 9.1 0.3 10.6 9.1 1.1 1 0 0 1 1 1 0 DDRGK domain DUF4050 PF13259.6 CDI85463.1 - 1.3 9.3 9.0 1.8 8.9 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) PepSY_TM PF03929.16 CDI85463.1 - 1.9 8.1 7.0 2.7 7.6 7.0 1.3 1 0 0 1 1 1 0 PepSY-associated TM region Neur_chan_memb PF02932.16 CDI85463.1 - 3.1 7.8 6.7 3.9 7.5 6.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Macoilin PF09726.9 CDI85463.1 - 9 4.7 16.0 12 4.3 16.0 1.1 1 0 0 1 1 1 0 Macoilin family BAF1_ABF1 PF04684.13 CDI85463.1 - 9.2 5.2 15.8 1.9 7.4 12.9 1.3 1 1 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Nop14 PF04147.12 CDI85464.1 - 2.6e-05 22.7 20.8 3e-05 22.5 20.8 1.0 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.14 CDI85464.1 - 0.0001 20.8 20.4 0.00011 20.7 20.4 1.0 1 0 0 1 1 1 1 CDC45-like protein Lin-8 PF03353.15 CDI85464.1 - 0.00042 20.0 25.0 0.00042 20.0 25.0 1.1 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist TFIIA PF03153.13 CDI85464.1 - 0.0013 18.8 44.0 0.0019 18.3 44.0 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Caldesmon PF02029.15 CDI85464.1 - 0.0026 16.6 26.4 0.0029 16.5 26.4 1.0 1 0 0 1 1 1 1 Caldesmon PNISR PF15996.5 CDI85464.1 - 0.0063 16.8 30.5 0.0076 16.5 30.5 1.2 1 0 0 1 1 1 1 Arginine/serine-rich protein PNISR Auxin_canalis PF05703.11 CDI85464.1 - 0.007 16.3 6.5 0.007 16.3 6.5 2.0 2 0 0 2 2 2 1 Auxin canalisation Presenilin PF01080.17 CDI85464.1 - 0.0072 15.1 29.1 0.0085 14.9 29.1 1.1 1 0 0 1 1 1 1 Presenilin NPR3 PF03666.13 CDI85464.1 - 0.0094 14.8 22.1 0.011 14.5 22.1 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 BUD22 PF09073.10 CDI85464.1 - 0.014 14.8 25.8 0.015 14.7 25.8 1.0 1 0 0 1 1 1 0 BUD22 DUF2126 PF09899.9 CDI85464.1 - 0.017 13.2 10.2 0.021 12.9 10.2 1.4 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF3292 PF11696.8 CDI85464.1 - 0.022 13.1 14.5 0.025 13.0 14.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) V_ATPase_I PF01496.19 CDI85464.1 - 0.024 12.6 26.4 0.031 12.2 26.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GREB1 PF15782.5 CDI85464.1 - 0.029 11.5 18.7 0.031 11.5 18.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peripla_BP_3 PF13377.6 CDI85464.1 - 0.03 14.6 3.4 0.042 14.2 3.4 1.3 1 0 0 1 1 1 0 Periplasmic binding protein-like domain DUF5427 PF10310.9 CDI85464.1 - 0.037 13.0 25.6 0.044 12.7 25.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DNA_pol_phi PF04931.13 CDI85464.1 - 0.038 12.1 27.5 0.049 11.7 27.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Mpp10 PF04006.12 CDI85464.1 - 0.054 11.9 35.2 0.061 11.8 35.2 1.0 1 0 0 1 1 1 0 Mpp10 protein SDA1 PF05285.12 CDI85464.1 - 0.11 11.9 29.6 0.13 11.6 29.6 1.1 1 0 0 1 1 1 0 SDA1 Med19 PF10278.9 CDI85464.1 - 0.11 12.4 19.0 0.15 11.9 19.0 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Hamartin PF04388.12 CDI85464.1 - 0.12 11.0 18.0 0.12 11.0 18.0 1.0 1 0 0 1 1 1 0 Hamartin protein SLC12 PF03522.15 CDI85464.1 - 0.12 11.3 27.2 0.14 11.1 27.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Gti1_Pac2 PF09729.9 CDI85464.1 - 0.13 12.4 17.6 0.2 11.8 17.6 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family RR_TM4-6 PF06459.12 CDI85464.1 - 0.13 12.1 31.1 0.16 11.8 31.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BAF1_ABF1 PF04684.13 CDI85464.1 - 0.14 11.2 25.6 0.23 10.5 25.6 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Neur_chan_memb PF02932.16 CDI85464.1 - 0.17 11.9 18.1 0.2 11.7 18.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CCSAP PF15748.5 CDI85464.1 - 0.18 11.9 29.8 0.23 11.6 29.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4045 PF13254.6 CDI85464.1 - 0.22 11.2 23.5 0.25 10.9 23.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PAT1 PF09770.9 CDI85464.1 - 0.22 9.7 38.0 0.25 9.6 38.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4638 PF15472.6 CDI85464.1 - 0.24 11.1 15.3 0.33 10.7 15.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Zip PF02535.22 CDI85464.1 - 0.35 10.1 16.8 0.44 9.7 16.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Sin_N PF04801.13 CDI85464.1 - 0.36 10.0 38.0 0.51 9.5 38.0 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region Hid1 PF12722.7 CDI85464.1 - 0.37 8.9 27.0 0.43 8.6 27.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Dicty_REP PF05086.12 CDI85464.1 - 0.38 8.7 12.6 0.51 8.3 12.6 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Rtf2 PF04641.12 CDI85464.1 - 0.44 9.9 22.7 0.63 9.4 22.7 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2828 PF11443.8 CDI85464.1 - 0.51 8.4 21.9 0.62 8.1 21.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Raftlin PF15250.6 CDI85464.1 - 0.6 8.8 21.4 0.68 8.6 21.4 1.0 1 0 0 1 1 1 0 Raftlin DUF2052 PF09747.9 CDI85464.1 - 0.65 10.1 37.7 0.87 9.7 37.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) ALMT PF11744.8 CDI85464.1 - 0.71 8.6 21.8 0.85 8.4 21.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Peroxin-3 PF04882.12 CDI85464.1 - 0.75 8.7 28.5 0.92 8.4 28.5 1.1 1 0 0 1 1 1 0 Peroxin-3 TT_ORF1 PF02956.14 CDI85464.1 - 1 8.0 11.5 1.1 7.8 11.5 1.1 1 0 0 1 1 1 0 TT viral orf 1 PCM1_C PF15717.5 CDI85464.1 - 1.1 7.8 31.9 1.5 7.5 31.9 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Endostatin PF06482.11 CDI85464.1 - 1.2 8.5 22.5 1.5 8.2 22.5 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin LAP1C PF05609.12 CDI85464.1 - 1.2 8.1 25.4 1.5 7.8 25.4 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF2151 PF10221.9 CDI85464.1 - 1.4 7.4 16.8 1.6 7.2 16.8 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Dapper PF15268.6 CDI85464.1 - 1.4 7.6 28.0 1.6 7.5 28.0 1.0 1 0 0 1 1 1 0 Dapper Ndc1_Nup PF09531.10 CDI85464.1 - 1.9 7.1 17.0 2.2 6.9 17.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Velvet PF11754.8 CDI85464.1 - 2.1 8.2 19.5 2.9 7.7 19.5 1.3 1 0 0 1 1 1 0 Velvet factor DUF4746 PF15928.5 CDI85464.1 - 2.2 7.6 27.7 2.8 7.3 27.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Peptidase_S64 PF08192.11 CDI85464.1 - 2.5 6.5 24.9 3 6.2 24.9 1.0 1 0 0 1 1 1 0 Peptidase family S64 SAPS PF04499.15 CDI85464.1 - 2.7 6.7 25.7 3.1 6.5 25.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Band_3_cyto PF07565.13 CDI85464.1 - 2.8 7.7 24.8 3.7 7.3 24.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Paf1 PF03985.13 CDI85464.1 - 2.9 6.8 42.1 3.9 6.4 42.1 1.1 1 0 0 1 1 1 0 Paf1 FAM60A PF15396.6 CDI85464.1 - 3.3 7.7 22.9 4.7 7.2 22.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DDRGK PF09756.9 CDI85464.1 - 3.4 7.2 41.9 5.1 6.6 41.9 1.3 1 0 0 1 1 1 0 DDRGK domain Membralin PF09746.9 CDI85464.1 - 3.9 6.4 17.1 4.4 6.2 17.1 1.1 1 0 0 1 1 1 0 Tumour-associated protein Apt1 PF10351.9 CDI85464.1 - 3.9 6.2 20.1 4.6 6.0 20.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SARG PF15385.6 CDI85464.1 - 4 6.5 31.7 5 6.2 31.7 1.0 1 0 0 1 1 1 0 Specifically androgen-regulated gene protein CAF1 PF04857.20 CDI85464.1 - 4 6.5 16.3 4.7 6.3 16.3 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease CAML PF14963.6 CDI85464.1 - 4.1 7.5 11.0 5 7.2 11.0 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand DUF966 PF06136.13 CDI85464.1 - 4.4 6.9 22.6 5.2 6.7 22.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) FRQ PF09421.10 CDI85464.1 - 4.9 5.1 18.9 5.9 4.8 18.9 1.0 1 0 0 1 1 1 0 Frequency clock protein AAA_11 PF13086.6 CDI85464.1 - 5.3 6.7 27.1 7.1 6.3 27.1 1.1 1 0 0 1 1 1 0 AAA domain VIR_N PF15912.5 CDI85464.1 - 5.4 6.5 24.5 7.7 6.0 24.5 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal XRN_M PF17846.1 CDI85464.1 - 6.8 5.5 23.0 7.6 5.4 23.0 1.1 1 0 0 1 1 1 0 Xrn1 helical domain HCO3_cotransp PF00955.21 CDI85464.1 - 6.8 5.4 10.1 8.2 5.1 10.1 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF4569 PF15133.6 CDI85464.1 - 8.5 6.0 28.1 11 5.7 28.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) GAGA_bind PF06217.12 CDI85464.1 - 9 6.5 21.3 10 6.3 21.3 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Kelch_4 PF13418.6 CDI85466.1 - 0.00046 20.1 0.1 0.0064 16.5 0.1 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 CDI85466.1 - 0.0033 17.7 1.8 1.2 9.6 0.0 4.3 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI85466.1 - 0.0068 16.4 0.0 0.3 11.1 0.0 3.6 3 0 0 3 3 3 1 Kelch motif TFIIA PF03153.13 CDI85467.1 - 5.9e-06 26.5 36.3 9.5e-06 25.9 36.3 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit O-antigen_lig PF13425.6 CDI85467.1 - 0.0071 15.2 0.1 0.0071 15.2 0.1 2.0 2 0 0 2 2 2 1 O-antigen ligase like membrane protein DUF4834 PF16118.5 CDI85467.1 - 0.16 13.0 0.3 0.16 13.0 0.3 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4834) OAD_gamma PF04277.13 CDI85467.1 - 0.18 12.5 3.1 0.31 11.7 0.0 2.6 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DcuA_DcuB PF03605.14 CDI85467.1 - 0.25 10.2 3.9 0.46 9.3 0.0 2.2 1 1 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter CSG2 PF16965.5 CDI85467.1 - 0.66 8.9 16.7 0.084 11.8 1.8 2.1 1 1 1 2 2 2 0 Ceramide synthase regulator DUF5523 PF17661.1 CDI85467.1 - 3.4 7.3 35.2 0.047 13.4 13.9 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF5523) RNA_pol_3_Rpc31 PF11705.8 CDI85467.1 - 4.9 7.3 32.5 0.028 14.7 17.1 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 DUF572 PF04502.13 CDI85467.1 - 7.8 6.0 28.5 0.36 10.4 10.9 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) Gaa1 PF04114.14 CDI85468.1 - 0.011 14.8 2.9 0.013 14.5 2.9 1.0 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component TFIIA PF03153.13 CDI85468.1 - 0.038 14.0 18.6 0.047 13.7 18.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CDI85468.1 - 0.11 12.0 10.3 0.12 11.9 10.3 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MAPEG PF01124.18 CDI85468.1 - 0.13 12.2 2.2 0.2 11.6 2.2 1.3 1 1 0 1 1 1 0 MAPEG family Med15 PF09606.10 CDI85468.1 - 0.52 8.9 18.6 0.58 8.8 18.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SRC-1 PF08832.10 CDI85468.1 - 0.53 11.4 8.1 0.067 14.2 2.7 1.9 2 0 0 2 2 2 0 Steroid receptor coactivator DUF4175 PF13779.6 CDI85468.1 - 1.1 7.1 15.9 1.2 6.9 15.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Presenilin PF01080.17 CDI85468.1 - 3.2 6.4 7.3 4.3 6.0 7.3 1.2 1 0 0 1 1 1 0 Presenilin Methyltr_RsmB-F PF01189.17 CDI85470.1 - 4.1e-08 33.1 3.9 6e-07 29.3 3.9 2.0 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Spt20 PF12090.8 CDI85470.1 - 0.00066 19.4 17.7 0.00088 19.0 17.7 1.1 1 0 0 1 1 1 1 Spt20 family MAP65_ASE1 PF03999.12 CDI85470.1 - 0.00077 18.3 5.8 0.00093 18.0 5.8 1.0 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) TFIIA PF03153.13 CDI85470.1 - 0.00082 19.5 12.4 0.00088 19.4 12.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF1645 PF07816.11 CDI85470.1 - 0.0029 18.2 4.2 0.0039 17.8 4.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1645) AF-4 PF05110.13 CDI85470.1 - 0.0043 15.2 13.5 0.0058 14.8 13.5 1.2 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Sporozoite_P67 PF05642.11 CDI85470.1 - 0.0086 14.2 0.4 0.0088 14.2 0.4 1.0 1 0 0 1 1 1 1 Sporozoite P67 surface antigen RskA PF10099.9 CDI85470.1 - 0.0096 16.2 5.1 0.0096 16.2 5.1 2.2 1 1 1 2 2 2 1 Anti-sigma-K factor rskA DUF775 PF05603.12 CDI85470.1 - 0.015 14.8 7.4 0.11 12.1 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF775) SPX PF03105.19 CDI85470.1 - 0.021 14.7 5.7 0.024 14.5 5.7 1.1 1 0 0 1 1 1 0 SPX domain RSF PF14876.6 CDI85470.1 - 0.033 13.2 0.4 0.033 13.2 0.4 1.6 2 0 0 2 2 2 0 Respiratory growth transcriptional regulator Presenilin PF01080.17 CDI85470.1 - 0.04 12.7 6.0 0.052 12.3 6.0 1.1 1 0 0 1 1 1 0 Presenilin DUF2722 PF10846.8 CDI85470.1 - 0.067 12.1 15.2 0.11 11.5 15.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Lin-8 PF03353.15 CDI85470.1 - 0.076 12.6 9.8 0.097 12.2 9.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MMU163 PF17119.5 CDI85470.1 - 0.093 11.9 1.1 0.12 11.5 1.1 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis FHIPEP PF00771.20 CDI85470.1 - 0.1 11.0 0.4 0.11 10.9 0.4 1.1 1 0 0 1 1 1 0 FHIPEP family Transposase_24 PF03004.14 CDI85470.1 - 0.13 12.4 0.3 0.13 12.4 0.3 2.1 2 0 0 2 2 2 0 Plant transposase (Ptta/En/Spm family) Miga PF10265.9 CDI85470.1 - 0.2 10.6 6.1 0.24 10.3 6.1 1.1 1 0 0 1 1 1 0 Mitoguardin Apt1 PF10351.9 CDI85470.1 - 0.21 10.4 7.4 0.25 10.1 7.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Conotoxin PF02950.17 CDI85470.1 - 0.21 12.6 5.3 7.2 7.7 0.3 2.3 2 0 0 2 2 2 0 Conotoxin MPM1 PF17234.2 CDI85470.1 - 0.22 11.8 6.7 0.32 11.2 6.7 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Peptidase_S64 PF08192.11 CDI85470.1 - 0.24 9.9 7.4 0.29 9.6 7.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF1180 PF06679.12 CDI85470.1 - 0.25 11.7 4.2 0.39 11.1 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) EPL1 PF10513.9 CDI85470.1 - 0.3 11.4 6.6 0.43 10.9 6.6 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Plasmodium_Vir PF05795.11 CDI85470.1 - 0.35 10.2 3.7 0.44 9.9 3.7 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Macoilin PF09726.9 CDI85470.1 - 0.37 9.3 8.2 0.51 8.8 8.2 1.2 1 0 0 1 1 1 0 Macoilin family GTSE1_N PF15259.6 CDI85470.1 - 1.3 9.2 10.6 0.75 10.0 3.8 2.1 2 0 0 2 2 2 0 G-2 and S-phase expressed 1 IMUP PF15761.5 CDI85470.1 - 2.7 8.7 12.6 0.57 10.9 9.0 1.7 2 0 0 2 2 1 0 Immortalisation up-regulated protein ANAPC_CDC26 PF10471.9 CDI85470.1 - 3.4 8.6 22.4 0.83 10.5 11.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Spt20 PF12090.8 CDI85471.1 - 0.00038 20.2 10.0 0.00038 20.2 10.0 6.4 6 0 0 6 6 6 4 Spt20 family Ribosomal_60s PF00428.19 CDI85471.1 - 0.0089 16.6 9.9 0.0089 16.6 9.9 27.5 20 5 6 26 26 26 3 60s Acidic ribosomal protein NAM-associated PF14303.6 CDI85473.1 - 0.00073 20.3 0.2 0.00073 20.3 0.2 6.3 1 1 2 5 5 5 1 No apical meristem-associated C-terminal domain SUIM_assoc PF16619.5 CDI85473.1 - 0.00084 19.4 0.0 0.00084 19.4 0.0 9.4 5 3 2 7 7 7 2 Unstructured region C-term to UIM in Ataxin3 SR-25 PF10500.9 CDI85473.1 - 0.021 14.4 90.3 0.012 15.3 11.8 5.0 4 1 1 5 5 5 0 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI85473.1 - 0.54 10.5 79.8 0.056 13.7 22.5 5.7 3 2 1 4 4 4 0 Anti-sigma-K factor rskA DUF1772 PF08592.11 CDI85473.1 - 0.59 10.5 6.8 5 7.4 1.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) Ribosomal_60s PF00428.19 CDI85473.1 - 2.1 9.0 45.1 0.36 11.5 15.6 5.1 3 1 1 4 4 4 0 60s Acidic ribosomal protein Kinase-like PF14531.6 CDI85474.1 - 0.0022 17.4 0.0 0.0043 16.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.25 CDI85474.1 - 0.0095 15.3 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Presenilin PF01080.17 CDI85475.1 - 2.5 6.8 53.3 4.3 6.0 53.3 1.4 1 0 0 1 1 1 0 Presenilin DUF755 PF05501.11 CDI85477.1 - 0.0011 19.2 25.0 0.0011 19.2 25.0 3.0 2 1 1 3 3 2 1 Domain of unknown function (DUF755) GREB1 PF15782.5 CDI85477.1 - 0.018 12.2 37.1 0.021 12.0 37.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Mucin PF01456.17 CDI85477.1 - 0.022 14.7 1.6 0.022 14.7 1.6 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein Cons_hypoth698 PF03601.14 CDI85477.1 - 0.033 13.1 0.2 0.033 13.1 0.2 2.1 2 0 0 2 2 2 0 Conserved hypothetical protein 698 DUF572 PF04502.13 CDI85477.1 - 0.039 13.6 27.4 0.062 12.9 27.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) RskA PF10099.9 CDI85477.1 - 0.044 14.1 33.0 4.1 7.7 16.3 2.3 1 1 1 2 2 2 0 Anti-sigma-K factor rskA HAD PF12710.7 CDI85477.1 - 0.052 13.9 2.0 0.079 13.4 2.0 1.4 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF5427 PF10310.9 CDI85477.1 - 0.21 10.5 30.5 0.26 10.2 30.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) V_ATPase_I PF01496.19 CDI85477.1 - 1.1 7.1 28.2 1.4 6.8 28.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SARAF PF06682.12 CDI85477.1 - 1.4 8.5 32.4 39 3.7 32.2 2.0 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis GAGA_bind PF06217.12 CDI85477.1 - 7.6 6.7 25.5 10 6.3 25.5 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family DUF3381 PF11861.8 CDI85477.1 - 8.6 6.1 34.8 1.1 9.1 5.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) MarC PF01914.17 CDI85477.1 - 9.3 5.6 8.1 5.9 6.2 0.3 2.6 3 0 0 3 3 3 0 MarC family integral membrane protein PUNUT PF16913.5 CDI85479.1 - 0.19 10.9 1.1 0.28 10.4 0.0 1.7 2 0 0 2 2 2 0 Purine nucleobase transmembrane transport DLIC PF05783.11 CDI85479.1 - 0.51 9.1 11.0 0.69 8.7 11.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) DUF3520 PF12034.8 CDI85479.1 - 0.57 10.3 6.9 0.94 9.6 6.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3520) NUDE_C PF04880.13 CDI85479.1 - 0.63 10.5 12.7 1.1 9.7 12.7 1.4 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Virul_Fac PF10139.9 CDI85479.1 - 0.95 7.6 12.8 1.4 7.0 12.8 1.4 1 0 0 1 1 1 0 Putative bacterial virulence factor Macoilin PF09726.9 CDI85479.1 - 1.3 7.5 12.2 1.7 7.1 12.2 1.1 1 0 0 1 1 1 0 Macoilin family Peptidase_S64 PF08192.11 CDI85479.1 - 2.2 6.6 6.5 2.5 6.5 6.5 1.2 1 0 0 1 1 1 0 Peptidase family S64 BAF1_ABF1 PF04684.13 CDI85479.1 - 2.5 7.1 16.3 3.8 6.4 16.3 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF2722 PF10846.8 CDI85480.1 - 0.0093 15.0 1.9 0.0093 15.0 1.9 10.3 3 2 3 6 6 6 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI85480.1 - 0.01 15.5 6.4 0.01 15.5 6.4 9.7 3 2 5 8 8 8 0 Spt20 family SR-25 PF10500.9 CDI85481.1 - 0.0047 16.6 18.8 0.0047 16.6 18.8 3.4 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein Corona_nucleoca PF00937.18 CDI85483.1 - 1.6 7.7 12.0 2.9 6.9 12.0 1.4 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein DUF572 PF04502.13 CDI85483.1 - 5.1 6.6 21.2 0.042 13.5 5.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) Apt1 PF10351.9 CDI85483.1 - 5.1 5.8 14.5 0.37 9.6 9.0 1.7 2 0 0 2 2 2 0 Golgi-body localisation protein domain Secretin_N_2 PF07655.13 CDI85483.1 - 5.6 7.6 25.3 11 6.7 25.3 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain DUF3987 PF13148.6 CDI85485.1 - 0.23 10.4 9.8 0.26 10.3 9.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Coilin_N PF15862.5 CDI85487.1 - 7e-06 25.9 1.6 7.5e-06 25.8 1.6 1.1 1 0 0 1 1 1 1 Coilin N-terminus TFIIA PF03153.13 CDI85487.1 - 5.8e-05 23.3 21.4 5.9e-05 23.2 21.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 CDI85487.1 - 0.0026 15.8 6.7 0.0035 15.4 6.7 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Shisa PF13908.6 CDI85487.1 - 0.0074 16.5 14.8 0.0074 16.5 14.8 2.1 1 1 1 2 2 2 1 Wnt and FGF inhibitory regulator SARAF PF06682.12 CDI85487.1 - 0.0092 15.7 5.4 0.0092 15.7 5.4 1.6 1 1 1 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis TRAP_alpha PF03896.16 CDI85487.1 - 0.011 15.0 4.8 0.026 13.7 4.8 1.7 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DDHD PF02862.17 CDI85487.1 - 0.014 15.6 4.3 0.015 15.5 4.3 1.1 1 0 0 1 1 1 0 DDHD domain DUF1980 PF09323.10 CDI85487.1 - 0.046 13.6 8.8 0.085 12.8 8.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) Spore_coat_CotO PF14153.6 CDI85487.1 - 0.059 13.3 14.5 0.077 12.9 14.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO PA26 PF04636.13 CDI85487.1 - 0.066 12.1 6.4 0.088 11.7 6.4 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) RNA_pol_Rpc4 PF05132.14 CDI85487.1 - 0.071 13.5 7.7 0.12 12.8 7.7 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF913 PF06025.12 CDI85487.1 - 0.083 11.9 6.6 0.093 11.7 6.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3810 PF12725.7 CDI85487.1 - 0.14 11.5 8.7 0.2 10.9 8.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) YABBY PF04690.13 CDI85487.1 - 0.15 12.6 6.1 0.23 12.0 6.1 1.4 1 0 0 1 1 1 0 YABBY protein SpoIIP PF07454.11 CDI85487.1 - 1.9 7.9 14.9 2.4 7.5 14.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TFB6 PF17110.5 CDI85487.1 - 2 8.2 7.1 2.5 7.8 7.1 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Spt20 PF12090.8 CDI85487.1 - 2.4 7.7 34.1 2.8 7.5 34.1 1.1 1 0 0 1 1 1 0 Spt20 family MMM1 PF10296.9 CDI85487.1 - 6.8 5.6 11.5 0.81 8.7 6.8 1.8 1 1 1 2 2 2 0 Maintenance of mitochondrial morphology protein 1 SID-1_RNA_chan PF13965.6 CDI85487.1 - 7.2 4.9 22.8 0.0059 15.1 8.4 2.0 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 MMR1 PF08505.10 CDI85487.1 - 8.7 6.6 16.2 11 6.3 16.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein TFIIA PF03153.13 CDI85488.1 - 0.0017 18.5 57.2 0.0027 17.8 57.2 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI85488.1 - 0.029 12.9 44.7 0.048 12.2 44.7 1.4 1 0 0 1 1 1 0 Macoilin family SARAF PF06682.12 CDI85488.1 - 1.7 8.2 45.8 0.071 12.8 22.9 2.7 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis STN1_2 PF09170.10 CDI85489.1 - 0.016 15.4 10.3 0.017 15.4 10.3 1.0 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 JmjC PF02373.22 CDI85489.1 - 8.7 6.8 11.3 11 6.5 11.3 1.0 1 0 0 1 1 1 0 JmjC domain, hydroxylase SelK_SelG PF10961.8 CDI85491.1 - 0.0029 18.2 0.1 0.008 16.8 0.1 1.8 1 0 0 1 1 1 1 Selenoprotein SelK_SelG DUF3071 PF11268.8 CDI85493.1 - 0.15 12.1 0.0 0.19 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Trypan_PARP PF05887.11 CDI85494.1 - 0.59 10.1 25.6 0.71 9.9 25.6 1.0 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF3381 PF11861.8 CDI85494.1 - 5.4 6.8 36.1 6.1 6.6 36.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Merozoite_SPAM PF07133.11 CDI85494.1 - 5.4 7.0 40.5 6.2 6.8 40.5 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Kei1 PF08552.11 CDI85495.1 - 0.0026 17.6 0.4 0.0026 17.6 0.4 2.1 1 1 1 2 2 2 1 Inositolphosphorylceramide synthase subunit Kei1 Plasmodium_Vir PF05795.11 CDI85495.1 - 0.0075 15.7 11.1 0.0088 15.5 11.1 1.1 1 0 0 1 1 1 1 Plasmodium vivax Vir protein Macoilin PF09726.9 CDI85495.1 - 0.32 9.5 31.4 0.41 9.1 31.4 1.0 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI85495.1 - 0.64 10.0 34.4 0.82 9.6 34.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4175 PF13779.6 CDI85495.1 - 0.7 7.7 24.9 0.8 7.5 24.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SPX PF03105.19 CDI85495.1 - 0.98 9.3 29.5 1.3 8.8 29.5 1.1 1 0 0 1 1 1 0 SPX domain PAT1 PF09770.9 CDI85495.1 - 2.2 6.5 23.0 2.6 6.2 23.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF572 PF04502.13 CDI85495.1 - 3.7 7.1 25.8 5.1 6.6 25.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF1764 PF08576.10 CDI85495.1 - 8.4 7.4 23.3 5.2 8.0 9.3 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) RLL PF10036.9 CDI85497.1 - 0.0018 18.1 4.9 0.0022 17.9 4.9 1.2 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein DUF2722 PF10846.8 CDI85497.1 - 0.0081 15.2 18.3 0.01 14.8 18.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DDHD PF02862.17 CDI85497.1 - 0.018 15.2 2.2 0.018 15.2 2.2 1.2 1 0 0 1 1 1 0 DDHD domain Draxin PF15550.6 CDI85497.1 - 0.035 14.0 8.3 0.054 13.4 8.3 1.3 1 0 0 1 1 1 0 Draxin Spt20 PF12090.8 CDI85497.1 - 0.036 13.7 30.4 0.047 13.3 30.4 1.3 1 0 0 1 1 1 0 Spt20 family EPL1 PF10513.9 CDI85497.1 - 0.039 14.4 7.3 0.045 14.1 7.3 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Otopetrin PF03189.13 CDI85497.1 - 0.16 10.8 0.2 0.13 11.0 0.2 1.1 1 0 0 1 1 1 0 Otopetrin DUF4647 PF15504.6 CDI85497.1 - 0.28 10.2 12.0 0.38 9.8 12.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) FAM176 PF14851.6 CDI85497.1 - 0.3 10.7 2.9 0.42 10.3 2.9 1.2 1 0 0 1 1 1 0 FAM176 family DUF4770 PF15994.5 CDI85497.1 - 0.33 11.2 8.1 0.43 10.8 8.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) SpoIIP PF07454.11 CDI85497.1 - 0.41 10.1 7.9 0.5 9.8 7.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CNDH2_M PF16869.5 CDI85497.1 - 0.47 11.1 7.1 0.73 10.5 7.1 1.3 1 0 0 1 1 1 0 PF16858 DUF4718 PF15842.5 CDI85497.1 - 0.55 10.0 7.1 0.88 9.4 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) MAP65_ASE1 PF03999.12 CDI85497.1 - 0.57 8.8 14.4 0.58 8.8 14.4 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) ALMT PF11744.8 CDI85497.1 - 0.57 8.9 6.6 0.68 8.7 6.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Conotoxin PF02950.17 CDI85497.1 - 0.73 10.9 8.2 2 9.5 8.2 1.9 1 1 0 1 1 1 0 Conotoxin Mcm10 PF09332.11 CDI85497.1 - 1.1 8.6 14.2 1.6 8.1 14.2 1.3 1 0 0 1 1 1 0 Mcm10 replication factor CLN3 PF02487.17 CDI85497.1 - 1.1 8.2 7.7 1.5 7.8 7.7 1.1 1 0 0 1 1 1 0 CLN3 protein Lin-8 PF03353.15 CDI85497.1 - 1.2 8.7 11.6 2 7.9 11.8 1.4 2 0 0 2 2 1 0 Ras-mediated vulval-induction antagonist Band_3_cyto PF07565.13 CDI85497.1 - 1.2 8.9 6.2 1.5 8.6 6.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2828 PF11443.8 CDI85497.1 - 1.6 6.7 9.1 2.1 6.3 9.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SLC12 PF03522.15 CDI85497.1 - 1.7 7.6 9.6 2 7.4 9.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI85497.1 - 1.8 6.7 21.7 1.8 6.7 21.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF702 PF05142.12 CDI85497.1 - 2 8.9 11.8 3.2 8.2 11.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF702) DUF966 PF06136.13 CDI85497.1 - 2.1 8.0 8.7 2.2 7.9 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Gti1_Pac2 PF09729.9 CDI85497.1 - 2.1 8.4 7.6 2.9 8.0 7.6 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Neur_chan_memb PF02932.16 CDI85497.1 - 2.4 8.2 7.6 3.2 7.8 7.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Connexin PF00029.19 CDI85497.1 - 3 7.5 6.6 3.7 7.2 6.6 1.1 1 0 0 1 1 1 0 Connexin MMR1 PF08505.10 CDI85497.1 - 3 8.1 14.1 4 7.7 14.1 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein OATP PF03137.20 CDI85497.1 - 3.2 5.9 4.4 3.5 5.8 4.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family UPF0560 PF10577.9 CDI85497.1 - 3.3 6.1 17.1 4.2 5.8 17.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TERB2 PF15101.6 CDI85497.1 - 4.4 7.3 17.7 6.4 6.8 17.7 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Hid1 PF12722.7 CDI85497.1 - 4.9 5.2 10.6 5.5 5.0 10.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CDI85497.1 - 5.6 5.6 14.4 6.9 5.3 14.4 1.1 1 0 0 1 1 1 0 Presenilin SOBP PF15279.6 CDI85497.1 - 5.8 7.4 34.1 7.2 7.1 34.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein RED_N PF07808.13 CDI85497.1 - 6.2 6.3 14.3 11 5.5 14.3 1.4 1 0 0 1 1 1 0 RED-like protein N-terminal region V_ATPase_I PF01496.19 CDI85497.1 - 6.6 4.5 11.3 7.9 4.3 11.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PIP5K PF01504.18 CDI85497.1 - 7.1 5.8 7.9 9.2 5.4 7.9 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase TMEM51 PF15345.6 CDI85497.1 - 7.5 6.3 19.1 8.6 6.1 18.0 1.8 1 1 0 1 1 1 0 Transmembrane protein 51 EIF4E-T PF10477.9 CDI85497.1 - 8.5 5.1 15.5 10 4.8 15.5 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF4638 PF15472.6 CDI85497.1 - 9.5 5.9 10.0 13 5.5 10.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DctQ PF04290.12 CDI85499.1 - 0.027 14.4 0.6 0.027 14.4 0.6 1.5 2 0 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component Ribosomal_60s PF00428.19 CDI85499.1 - 0.035 14.7 11.8 0.035 14.7 11.8 3.2 1 1 2 3 3 3 0 60s Acidic ribosomal protein DUF2126 PF09899.9 CDI85499.1 - 0.077 11.1 3.6 0.098 10.7 3.6 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) MMR1 PF08505.10 CDI85499.1 - 0.51 10.6 6.3 0.63 10.3 6.3 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein EIF4E-T PF10477.9 CDI85499.1 - 2 7.1 11.7 2 7.1 11.7 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF4813 PF16072.5 CDI85499.1 - 2.9 7.5 32.4 3.1 7.4 32.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) TctB PF07331.11 CDI85499.1 - 3 8.1 7.6 4.3 7.6 7.6 1.3 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family SKA1 PF07160.12 CDI85499.1 - 9 6.1 14.3 9.4 6.0 14.3 1.3 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DNA_pol_phi PF04931.13 CDI85500.1 - 0.00016 19.9 16.0 0.00016 19.9 16.0 1.2 1 0 0 1 1 1 1 DNA polymerase phi FHIPEP PF00771.20 CDI85500.1 - 0.00032 19.3 1.0 0.00037 19.1 1.0 1.0 1 0 0 1 1 1 1 FHIPEP family BUD22 PF09073.10 CDI85500.1 - 0.0045 16.4 9.0 0.0045 16.4 9.0 1.1 1 0 0 1 1 1 1 BUD22 RPN2_C PF18004.1 CDI85500.1 - 0.0077 16.2 9.3 0.0078 16.2 9.3 1.1 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain RNA_pol_3_Rpc31 PF11705.8 CDI85500.1 - 0.013 15.7 16.5 0.016 15.5 16.5 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF2052 PF09747.9 CDI85500.1 - 0.02 15.0 15.4 0.026 14.7 15.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DARPP-32 PF05395.12 CDI85500.1 - 0.021 15.0 12.5 0.026 14.7 12.5 1.2 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 RskA PF10099.9 CDI85500.1 - 0.023 15.0 6.8 0.09 13.1 6.8 1.8 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Connexin PF00029.19 CDI85500.1 - 0.03 14.1 3.1 0.032 14.0 3.1 1.1 1 0 0 1 1 1 0 Connexin RNA_pol_Rpc4 PF05132.14 CDI85500.1 - 0.037 14.5 5.0 0.046 14.1 5.0 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Vfa1 PF08432.10 CDI85500.1 - 0.04 14.3 5.9 0.041 14.2 5.9 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Na_trans_assoc PF06512.13 CDI85500.1 - 0.046 14.0 9.6 0.071 13.4 9.6 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated Presenilin PF01080.17 CDI85500.1 - 0.056 12.2 3.7 0.053 12.3 3.7 1.1 1 0 0 1 1 1 0 Presenilin Mpp10 PF04006.12 CDI85500.1 - 0.081 11.4 19.0 0.089 11.2 19.0 1.0 1 0 0 1 1 1 0 Mpp10 protein HDOD PF08668.12 CDI85500.1 - 0.084 12.3 2.4 0.099 12.1 2.4 1.2 1 0 0 1 1 1 0 HDOD domain PI3K_1B_p101 PF10486.9 CDI85500.1 - 0.098 10.4 4.5 0.085 10.6 4.5 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF1772 PF08592.11 CDI85500.1 - 0.1 12.9 3.8 0.19 12.0 3.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) DUF913 PF06025.12 CDI85500.1 - 0.1 11.5 5.3 0.11 11.4 5.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SID-1_RNA_chan PF13965.6 CDI85500.1 - 0.11 11.0 0.5 0.11 10.9 0.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RR_TM4-6 PF06459.12 CDI85500.1 - 0.11 12.3 12.2 0.13 12.1 12.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FYDLN_acid PF09538.10 CDI85500.1 - 0.13 12.9 12.8 0.22 12.2 12.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) TRAP_alpha PF03896.16 CDI85500.1 - 0.14 11.3 10.7 0.15 11.3 10.7 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RAB3GAP2_C PF14656.6 CDI85500.1 - 0.15 10.2 4.9 0.14 10.3 4.9 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus SDA1 PF05285.12 CDI85500.1 - 0.16 11.3 19.5 0.18 11.2 19.5 1.1 1 0 0 1 1 1 0 SDA1 AMP-binding PF00501.28 CDI85500.1 - 0.16 10.5 3.3 0.19 10.3 3.3 1.0 1 0 0 1 1 1 0 AMP-binding enzyme DDHD PF02862.17 CDI85500.1 - 0.2 11.8 3.0 0.21 11.7 3.0 1.1 1 0 0 1 1 1 0 DDHD domain Paf1 PF03985.13 CDI85500.1 - 0.24 10.3 22.0 0.27 10.2 22.0 1.0 1 0 0 1 1 1 0 Paf1 V_ATPase_I PF01496.19 CDI85500.1 - 0.32 8.9 5.2 0.31 8.9 5.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nop14 PF04147.12 CDI85500.1 - 0.37 9.0 21.0 0.4 8.8 21.0 1.0 1 0 0 1 1 1 0 Nop14-like family Sporozoite_P67 PF05642.11 CDI85500.1 - 0.38 8.8 4.9 0.4 8.7 4.9 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF5523 PF17661.1 CDI85500.1 - 0.39 10.4 19.1 0.42 10.3 19.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) GNAT_acetyltr_2 PF13718.6 CDI85500.1 - 0.41 10.0 3.7 0.41 10.0 3.7 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 CDC45 PF02724.14 CDI85500.1 - 0.42 8.9 14.4 0.45 8.8 14.4 1.0 1 0 0 1 1 1 0 CDC45-like protein ADP_ribosyl_GH PF03747.14 CDI85500.1 - 0.45 10.2 5.8 0.56 9.9 5.8 1.2 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase CLN3 PF02487.17 CDI85500.1 - 0.53 9.3 1.9 0.52 9.3 1.9 1.1 1 0 0 1 1 1 0 CLN3 protein TFB6 PF17110.5 CDI85500.1 - 0.59 9.9 10.6 0.74 9.5 10.6 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH EIIBC-GUT_N PF03612.14 CDI85500.1 - 0.67 9.7 5.2 0.72 9.6 5.2 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Astro_capsid_p PF12226.8 CDI85500.1 - 0.78 8.8 17.6 0.93 8.6 17.6 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Pox_Ag35 PF03286.14 CDI85500.1 - 0.83 9.4 13.5 1 9.1 13.5 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF1115 PF06544.12 CDI85500.1 - 0.96 9.5 6.1 1.2 9.3 6.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) PPP4R2 PF09184.11 CDI85500.1 - 1 8.9 18.2 1.1 8.8 18.2 1.1 1 0 0 1 1 1 0 PPP4R2 DUF4471 PF14740.6 CDI85500.1 - 1 8.5 6.0 1.2 8.4 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) SpoIIP PF07454.11 CDI85500.1 - 1 8.8 11.3 1.2 8.5 11.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Afi1 PF07792.12 CDI85500.1 - 1 9.8 7.8 1.2 9.6 7.8 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking NOA36 PF06524.12 CDI85500.1 - 1.1 8.5 15.6 1.4 8.2 15.6 1.2 1 0 0 1 1 1 0 NOA36 protein DUF740 PF05340.12 CDI85500.1 - 1.2 7.8 11.2 1.2 7.8 11.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF740) RP-C_C PF11800.8 CDI85500.1 - 1.2 9.2 11.1 1.6 8.8 11.1 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Spore_coat_CotO PF14153.6 CDI85500.1 - 2.1 8.3 15.1 2.5 8.0 15.1 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Serinc PF03348.15 CDI85500.1 - 2.1 7.2 3.2 2.1 7.2 3.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF1682 PF07946.14 CDI85500.1 - 2.4 7.3 11.9 2.2 7.4 11.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CENP-T_N PF16171.5 CDI85500.1 - 3 6.6 11.0 3.3 6.5 11.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T N-terminus Eapp_C PF10238.9 CDI85500.1 - 3.8 7.6 7.9 5.3 7.1 7.9 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein MAP17 PF15807.5 CDI85500.1 - 5.1 7.3 12.6 7.1 6.9 12.6 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 MRNIP PF15749.5 CDI85500.1 - 5.3 7.8 10.6 6.9 7.4 10.6 1.2 1 0 0 1 1 1 0 MRN-interacting protein G0-G1_switch_2 PF15103.6 CDI85500.1 - 5.8 7.4 8.5 8.4 6.9 8.5 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 PA26 PF04636.13 CDI85500.1 - 6.3 5.6 6.2 6.2 5.6 6.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PTPRCAP PF15713.5 CDI85500.1 - 6.5 7.0 23.0 9.5 6.5 23.0 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF4179 PF13786.6 CDI85500.1 - 6.6 7.3 6.7 9.1 6.8 6.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) DUF3381 PF11861.8 CDI85500.1 - 6.7 6.5 20.5 8.4 6.2 20.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Merozoite_SPAM PF07133.11 CDI85500.1 - 8.1 6.4 41.7 9.6 6.2 41.7 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Nop53 PF07767.11 CDI85500.1 - 9.8 5.5 22.1 11 5.3 22.1 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SAPS PF04499.15 CDI85501.1 - 0.68 8.7 4.7 0.71 8.6 4.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Pkinase PF00069.25 CDI85502.1 - 1.1e-12 47.9 0.1 7.2e-11 42.0 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain Spt20 PF12090.8 CDI85502.1 - 0.00032 20.4 43.3 0.054 13.1 1.4 2.4 2 0 0 2 2 2 2 Spt20 family TFIIA PF03153.13 CDI85502.1 - 0.00034 20.7 30.0 0.013 15.5 19.8 2.7 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Pkinase_Tyr PF07714.17 CDI85502.1 - 0.0089 15.3 0.8 0.83 8.9 0.1 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Med15 PF09606.10 CDI85502.1 - 0.56 8.8 29.3 0.59 8.8 1.1 2.6 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF1645 PF07816.11 CDI85502.1 - 0.61 10.6 31.3 2.4 8.7 0.3 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1645) DUF572 PF04502.13 CDI85502.1 - 0.72 9.4 18.7 3.5 7.1 16.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) Neur_chan_memb PF02932.16 CDI85502.1 - 1.6 8.7 10.1 13 5.7 8.6 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Alpha_adaptinC2 PF02883.20 CDI85503.1 - 1.3e-16 60.9 0.2 5.7e-16 58.8 0.0 2.2 2 0 0 2 2 2 1 Adaptin C-terminal domain Adaptin_N PF01602.20 CDI85503.1 - 3.4e-10 39.1 1.3 6e-09 35.0 1.3 2.0 1 1 0 1 1 1 1 Adaptin N terminal region SUIM_assoc PF16619.5 CDI85503.1 - 0.015 15.3 11.9 0.14 12.2 0.9 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 HIP1_clath_bdg PF16515.5 CDI85503.1 - 2.9 8.6 13.8 0.44 11.2 0.6 3.1 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Adaptin_N PF01602.20 CDI85504.1 - 8.7e-24 84.0 0.2 1.6e-23 83.1 0.2 1.4 1 0 0 1 1 1 1 Adaptin N terminal region Endostatin PF06482.11 CDI85504.1 - 0.67 9.4 22.1 0.99 8.8 22.1 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF2052 PF09747.9 CDI85504.1 - 0.84 9.7 25.1 1.3 9.1 25.1 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) LMBR1 PF04791.16 CDI85504.1 - 4.3 6.1 8.9 4.1 6.2 8.9 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein RR_TM4-6 PF06459.12 CDI85504.1 - 4.6 7.0 29.1 6.5 6.5 29.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 XRN_M PF17846.1 CDI85504.1 - 7.8 5.3 17.4 9.9 5.0 17.4 1.1 1 0 0 1 1 1 0 Xrn1 helical domain SR-25 PF10500.9 CDI85505.1 - 0.02 14.5 10.3 0.024 14.3 10.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1635 PF07795.11 CDI85505.1 - 0.048 13.5 5.0 0.055 13.3 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Spt20 PF12090.8 CDI85505.1 - 0.38 10.3 12.3 0.43 10.1 12.3 1.2 1 0 0 1 1 1 0 Spt20 family Ndc1_Nup PF09531.10 CDI85505.1 - 0.39 9.4 13.2 0.44 9.2 13.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup XRN_M PF17846.1 CDI85505.1 - 1.2 8.1 3.3 1.3 7.9 3.3 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Miga PF10265.9 CDI85505.1 - 1.4 7.8 10.7 1.6 7.6 10.7 1.0 1 0 0 1 1 1 0 Mitoguardin PP_M1 PF03012.14 CDI85505.1 - 1.5 8.3 8.5 1.6 8.2 8.5 1.0 1 0 0 1 1 1 0 Phosphoprotein Smg8_Smg9 PF10220.9 CDI85505.1 - 1.9 6.7 8.2 2.1 6.6 8.2 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Lin-8 PF03353.15 CDI85505.1 - 2.3 7.7 9.7 2.3 7.7 9.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist FAM199X PF15814.5 CDI85505.1 - 2.8 6.9 17.3 3.1 6.8 17.3 1.2 1 0 0 1 1 1 0 Protein family FAM199X Macoilin PF09726.9 CDI85505.1 - 5.3 5.5 10.4 6.6 5.2 10.4 1.2 1 0 0 1 1 1 0 Macoilin family Neur_chan_memb PF02932.16 CDI85505.1 - 6.5 6.7 6.2 7.3 6.6 6.2 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TFIIA PF03153.13 CDI85505.1 - 6.9 6.5 22.7 8.6 6.2 22.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Trs65 PF12735.7 CDI85505.1 - 9.1 5.6 9.6 10 5.4 9.6 1.1 1 0 0 1 1 1 0 TRAPP trafficking subunit Trs65 EF1_GNE PF00736.19 CDI85506.1 - 8.2e-11 41.9 2.3 8.2e-11 41.9 2.3 2.9 2 1 0 2 2 2 1 EF-1 guanine nucleotide exchange domain Ran-binding PF05508.11 CDI85506.1 - 0.0055 15.7 2.7 0.0064 15.5 2.7 1.0 1 0 0 1 1 1 1 RanGTP-binding protein Spot_14 PF07084.12 CDI85506.1 - 0.037 14.2 2.2 0.049 13.8 2.2 1.2 1 0 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 PBP1_TM PF14812.6 CDI85506.1 - 0.21 12.0 7.4 3.7 8.0 1.9 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4611 PF15387.6 CDI85506.1 - 2.2 8.5 14.4 0.11 12.7 3.7 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4611) RNA_pol_3_Rpc31 PF11705.8 CDI85506.1 - 9.1 6.5 16.7 13 6.0 16.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF2722 PF10846.8 CDI85507.1 - 0.092 11.7 4.8 0.12 11.3 4.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI85507.1 - 0.77 9.3 9.4 1.1 8.8 9.4 1.2 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 CDI85507.1 - 4.1 6.4 6.7 6.1 5.8 6.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF4490 PF14892.6 CDI85508.1 - 2.7e-07 30.6 0.0 3.6e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4490) PAS_4 PF08448.10 CDI85511.1 - 1.3 9.3 7.1 1.1 9.6 0.1 2.3 2 1 0 2 2 2 0 PAS fold eIF_4EBP PF05456.11 CDI85511.1 - 3.7 7.5 18.3 1.3 9.0 10.1 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) SRP72 PF08492.12 CDI85511.1 - 4.9 7.6 13.3 0.29 11.6 2.0 2.5 2 0 0 2 2 2 0 SRP72 RNA-binding domain TRAUB PF08164.12 CDI85511.1 - 6.3 7.4 14.7 0.17 12.5 0.8 2.4 2 0 0 2 2 2 0 Apoptosis-antagonizing transcription factor, C-terminal Consortin_C PF15281.6 CDI85511.1 - 8.7 6.4 11.4 0.36 10.8 1.1 2.2 2 0 0 2 2 2 0 Consortin C-terminus Podoplanin PF05808.11 CDI85511.1 - 9.4 6.3 8.3 2.6 8.1 0.7 2.1 2 0 0 2 2 2 0 Podoplanin RskA PF10099.9 CDI85512.1 - 3.5e-05 24.2 17.5 3.5e-05 24.2 17.5 4.3 2 1 1 3 3 3 1 Anti-sigma-K factor rskA Med15 PF09606.10 CDI85512.1 - 0.0018 17.1 17.2 0.0018 17.1 17.2 2.5 3 0 0 3 3 3 1 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI85513.1 - 5.7e-08 33.2 98.6 3.4e-06 27.3 33.6 3.2 3 0 0 3 3 3 3 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI85513.1 - 0.00029 20.5 9.2 0.00029 20.5 9.2 5.9 5 1 1 6 6 6 2 Nuclear RNA-splicing-associated protein MMR1 PF08505.10 CDI85514.1 - 0.001 19.4 30.1 0.0011 19.3 30.1 1.0 1 0 0 1 1 1 1 Mitochondrial Myo2 receptor-related protein Activator_LAG-3 PF11498.8 CDI85514.1 - 0.013 14.5 38.2 0.017 14.1 38.2 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TMEM51 PF15345.6 CDI85514.1 - 0.024 14.5 15.1 0.033 14.0 15.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 DDRGK PF09756.9 CDI85514.1 - 0.031 13.9 17.1 0.035 13.7 17.1 1.1 1 0 0 1 1 1 0 DDRGK domain BSP_II PF05432.11 CDI85514.1 - 0.077 12.7 15.7 0.084 12.6 15.7 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CCSAP PF15748.5 CDI85514.1 - 0.095 12.9 26.9 0.1 12.7 26.9 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Corona_nucleoca PF00937.18 CDI85514.1 - 0.1 11.6 22.8 0.12 11.4 22.8 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Bcl-2_BAD PF10514.9 CDI85514.1 - 0.13 12.7 18.9 0.16 12.4 18.9 1.1 1 0 0 1 1 1 0 Pro-apoptotic Bcl-2 protein, BAD DUF5385 PF17359.2 CDI85514.1 - 0.25 10.9 13.4 0.31 10.6 13.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) V_ATPase_I PF01496.19 CDI85514.1 - 0.26 9.2 18.3 0.31 8.9 18.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SOBP PF15279.6 CDI85514.1 - 0.28 11.8 23.9 0.3 11.7 23.9 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein TCP PF03634.13 CDI85514.1 - 0.3 11.6 22.5 0.38 11.3 22.5 1.1 1 0 0 1 1 1 0 TCP family transcription factor DUF3984 PF13136.6 CDI85514.1 - 0.3 10.4 23.9 0.36 10.2 23.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) TFIIA PF03153.13 CDI85514.1 - 0.38 10.7 38.8 0.47 10.4 38.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PPP4R2 PF09184.11 CDI85514.1 - 0.39 10.3 19.9 0.47 10.0 19.9 1.0 1 0 0 1 1 1 0 PPP4R2 Endostatin PF06482.11 CDI85514.1 - 0.43 10.0 20.4 0.49 9.8 20.4 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin eIF3_subunit PF08597.10 CDI85514.1 - 0.45 10.4 17.4 0.5 10.2 17.4 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Dicty_REP PF05086.12 CDI85514.1 - 0.54 8.2 18.4 0.62 8.0 18.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SprA-related PF12118.8 CDI85514.1 - 0.55 9.3 35.7 0.65 9.1 35.7 1.0 1 0 0 1 1 1 0 SprA-related family PBP_sp32 PF07222.12 CDI85514.1 - 0.66 9.4 23.7 0.84 9.1 23.7 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Peptidase_S49_N PF08496.10 CDI85514.1 - 0.67 10.0 12.1 0.77 9.8 12.1 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF2828 PF11443.8 CDI85514.1 - 0.82 7.7 14.5 0.81 7.7 14.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SelP_N PF04592.14 CDI85514.1 - 0.82 9.0 23.4 1.2 8.5 23.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF5523 PF17661.1 CDI85514.1 - 1 9.0 19.3 1.2 8.8 19.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Presenilin PF01080.17 CDI85514.1 - 1.1 8.0 27.3 1.2 7.8 27.3 1.0 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI85514.1 - 1.1 9.0 22.0 1.4 8.7 22.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF572 PF04502.13 CDI85514.1 - 1.2 8.7 23.3 1.5 8.4 23.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) eIF-3_zeta PF05091.12 CDI85514.1 - 1.3 7.9 20.3 1.4 7.8 20.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Velvet PF11754.8 CDI85514.1 - 1.5 8.7 23.3 2 8.3 23.3 1.2 1 0 0 1 1 1 0 Velvet factor PA26 PF04636.13 CDI85514.1 - 1.6 7.5 19.0 1.9 7.3 19.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Asparaginase_2 PF01112.18 CDI85514.1 - 2.2 7.2 9.1 2.7 6.9 9.1 1.1 1 0 0 1 1 1 0 Asparaginase MAP70 PF07058.11 CDI85514.1 - 2.3 6.9 17.0 2.8 6.6 17.0 1.0 1 0 0 1 1 1 0 Microtubule-associated protein 70 CDC45 PF02724.14 CDI85514.1 - 2.7 6.2 23.2 3.1 6.0 23.2 1.0 1 0 0 1 1 1 0 CDC45-like protein FHIPEP PF00771.20 CDI85514.1 - 3 6.2 8.2 3.6 5.9 8.2 1.1 1 0 0 1 1 1 0 FHIPEP family DUF4175 PF13779.6 CDI85514.1 - 3.1 5.6 30.3 3.2 5.6 30.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Serinc PF03348.15 CDI85514.1 - 3.8 6.3 13.3 4.7 6.0 13.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) SR-25 PF10500.9 CDI85514.1 - 3.8 7.1 36.5 7.8 6.0 36.5 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF778 PF05608.12 CDI85514.1 - 3.9 7.8 13.3 4.9 7.5 13.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF778) FAM199X PF15814.5 CDI85514.1 - 4.9 6.1 19.4 6.5 5.7 19.4 1.2 1 0 0 1 1 1 0 Protein family FAM199X Neur_chan_memb PF02932.16 CDI85514.1 - 5 7.1 17.0 6.8 6.7 17.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PNISR PF15996.5 CDI85514.1 - 5.1 7.3 24.8 7 6.9 24.8 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF4407 PF14362.6 CDI85514.1 - 5.3 6.3 14.6 5.5 6.2 14.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SMYLE_N PF18615.1 CDI85514.1 - 6 6.3 19.7 7.1 6.1 19.7 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain PAT1 PF09770.9 CDI85514.1 - 6.2 5.0 29.0 6.6 4.9 29.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 UNC-79 PF14776.6 CDI85514.1 - 6.9 5.3 10.2 8.3 5.0 10.2 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 DUF1387 PF07139.11 CDI85514.1 - 7.7 6.1 26.1 9.5 5.9 26.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DcuA_DcuB PF03605.14 CDI85514.1 - 8.3 5.2 5.9 11 4.8 5.9 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Spem1 PF15670.5 CDI85514.1 - 9.3 5.7 18.4 12 5.4 18.4 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 VIR_N PF15912.5 CDI85514.1 - 9.7 5.7 13.4 12 5.4 13.4 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Symplekin_C PF12295.8 CDI85515.1 - 4e-36 124.9 0.7 1e-35 123.5 0.7 1.8 1 0 0 1 1 1 1 Symplekin tight junction protein C terminal TPPII_N PF12583.8 CDI85515.1 - 0.013 16.1 16.9 0.013 16.1 16.9 2.3 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal BRF1 PF07741.13 CDI85515.1 - 3.4 8.1 0.0 3.4 8.1 0.0 3.6 4 0 0 4 4 4 0 Brf1-like TBP-binding domain DUF4834 PF16118.5 CDI85515.1 - 4.1 8.4 8.7 7.2 7.6 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) WD40 PF00400.32 CDI85516.1 - 0.00065 20.5 9.4 0.021 15.7 0.0 4.2 5 0 0 5 5 5 2 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 CDI85516.1 - 0.0016 18.7 0.0 0.0047 17.2 0.0 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex SR-25 PF10500.9 CDI85516.1 - 0.0017 18.0 2.7 0.0017 18.0 2.7 3.3 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI85516.1 - 0.0024 16.9 3.3 0.0024 16.9 3.3 4.1 2 2 1 3 3 3 1 Protein of unknown function (DUF2722) K_channel_TID PF07941.11 CDI85516.1 - 0.015 15.7 3.8 0.015 15.7 3.8 6.4 6 1 0 6 6 6 0 Potassium channel Kv1.4 tandem inactivation domain Exonuc_V_gamma PF04257.14 CDI85522.1 - 0.044 12.0 0.0 0.06 11.6 0.0 1.1 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit ACT_6 PF13740.6 CDI85524.1 - 0.16 12.0 0.0 0.44 10.6 0.0 1.7 1 0 0 1 1 1 0 ACT domain MAR_sialic_bdg PF10564.9 CDI85526.1 - 5.1e-05 23.2 8.8 0.00094 19.2 0.5 3.3 3 0 0 3 3 3 2 Sialic-acid binding micronemal adhesive repeat PNISR PF15996.5 CDI85527.1 - 0.089 13.1 26.3 0.094 13.0 26.3 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Presenilin PF01080.17 CDI85527.1 - 0.16 10.7 23.9 0.16 10.7 23.9 1.1 1 0 0 1 1 1 0 Presenilin DUF3292 PF11696.8 CDI85527.1 - 0.28 9.5 15.4 0.28 9.5 15.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) PAT1 PF09770.9 CDI85527.1 - 0.32 9.2 34.0 0.33 9.2 34.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S64 PF08192.11 CDI85527.1 - 0.63 8.5 16.6 0.6 8.5 16.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF3295 PF11702.8 CDI85527.1 - 0.66 9.3 21.9 0.7 9.2 21.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Dapper PF15268.6 CDI85527.1 - 1.4 7.7 24.9 1.4 7.7 24.9 1.1 1 0 0 1 1 1 0 Dapper Pex14_N PF04695.13 CDI85527.1 - 1.5 9.4 36.3 0.41 11.3 32.8 1.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Otopetrin PF03189.13 CDI85527.1 - 1.7 7.3 7.1 1.6 7.4 7.1 1.2 1 0 0 1 1 1 0 Otopetrin Zip PF02535.22 CDI85527.1 - 1.9 7.7 9.6 2 7.6 9.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SRP-alpha_N PF04086.13 CDI85527.1 - 2.8 7.8 22.1 3 7.7 22.1 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SPX PF03105.19 CDI85527.1 - 3 7.7 18.7 3.3 7.5 18.7 1.2 1 0 0 1 1 1 0 SPX domain DUF1917 PF08939.10 CDI85527.1 - 3.7 7.4 16.0 5.9 6.7 16.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) Plasmodium_Vir PF05795.11 CDI85527.1 - 3.7 6.9 12.2 4.5 6.6 12.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Apt1 PF10351.9 CDI85527.1 - 5.8 5.6 15.6 5.8 5.7 15.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Mitofilin PF09731.9 CDI85527.1 - 6.7 5.4 33.2 8.1 5.1 33.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein NST1 PF13945.6 CDI85527.1 - 7.3 6.7 31.0 11 6.1 31.0 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator TFIIA PF03153.13 CDI85528.1 - 0.00046 20.3 25.7 0.00059 19.9 25.7 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI85528.1 - 0.017 14.1 17.1 0.032 13.2 17.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DDHD PF02862.17 CDI85528.1 - 0.019 15.2 0.8 0.022 14.9 0.8 1.3 1 0 0 1 1 1 0 DDHD domain Ndc1_Nup PF09531.10 CDI85528.1 - 0.036 12.8 9.9 0.041 12.6 9.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SMYLE_N PF18615.1 CDI85528.1 - 0.054 13.1 5.1 0.078 12.5 5.1 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Raftlin PF15250.6 CDI85528.1 - 0.065 12.0 7.0 0.084 11.6 7.0 1.0 1 0 0 1 1 1 0 Raftlin Presenilin PF01080.17 CDI85528.1 - 0.12 11.1 8.8 0.15 10.8 8.8 1.2 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 CDI85528.1 - 0.2 10.4 2.6 0.23 10.2 2.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Spt20 PF12090.8 CDI85528.1 - 0.3 10.7 26.0 0.49 10.0 26.0 1.3 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI85528.1 - 0.3 12.1 6.6 0.49 11.4 6.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SOG2 PF10428.9 CDI85528.1 - 0.32 10.2 9.4 0.37 9.9 9.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Neur_chan_memb PF02932.16 CDI85528.1 - 0.33 11.0 1.9 0.4 10.7 1.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SpoIIP PF07454.11 CDI85528.1 - 0.37 10.2 5.9 0.5 9.8 5.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) MID_MedPIWI PF18296.1 CDI85528.1 - 0.47 10.2 7.1 0.59 9.9 7.1 1.3 1 0 0 1 1 1 0 MID domain of medPIWI FAM60A PF15396.6 CDI85528.1 - 0.76 9.8 4.7 1 9.3 4.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Serinc PF03348.15 CDI85528.1 - 0.86 8.5 2.0 1.1 8.2 2.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Pol_alpha_B_N PF08418.10 CDI85528.1 - 1 9.3 11.3 1.6 8.7 11.3 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DUF4820 PF16091.5 CDI85528.1 - 1.2 8.5 5.9 1.8 7.9 5.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) eIF-3_zeta PF05091.12 CDI85528.1 - 1.5 7.7 6.9 1.8 7.4 6.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Hamartin PF04388.12 CDI85528.1 - 1.6 7.3 8.0 1.9 7.0 8.0 1.1 1 0 0 1 1 1 0 Hamartin protein Spore_coat_CotO PF14153.6 CDI85528.1 - 1.8 8.4 15.4 2.8 7.8 15.4 1.4 1 0 0 1 1 1 0 Spore coat protein CotO Suf PF05843.14 CDI85528.1 - 2.2 8.2 13.3 2.9 7.8 13.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Myc_N PF01056.18 CDI85528.1 - 2.4 8.0 12.6 3.7 7.3 12.6 1.2 1 0 0 1 1 1 0 Myc amino-terminal region MAJIN PF15077.6 CDI85528.1 - 3 7.6 5.0 4.4 7.0 5.0 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF5327 PF17261.2 CDI85528.1 - 3.2 8.5 16.9 1.2 9.9 13.9 1.8 2 0 0 2 2 1 0 Family of unknown function (DUF5327) DUF913 PF06025.12 CDI85528.1 - 3.4 6.5 6.1 4.1 6.3 6.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Peroxin-3 PF04882.12 CDI85528.1 - 3.9 6.4 11.3 4.7 6.1 11.3 1.2 1 0 0 1 1 1 0 Peroxin-3 TERB2 PF15101.6 CDI85528.1 - 7.1 6.6 10.3 11 6.0 10.3 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 RR_TM4-6 PF06459.12 CDI85528.1 - 9.5 6.0 10.9 13 5.5 10.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Coilin_N PF15862.5 CDI85528.1 - 9.6 6.0 11.9 15 5.4 11.9 1.3 1 0 0 1 1 1 0 Coilin N-terminus FAM199X PF15814.5 CDI85528.1 - 9.6 5.2 10.3 15 4.6 10.3 1.4 1 0 0 1 1 1 0 Protein family FAM199X RVT_1 PF00078.27 CDI85529.1 - 0.0047 16.5 0.0 0.11 12.0 0.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 CDI85529.1 - 0.015 16.1 0.4 0.042 14.7 0.4 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger DUF4129 PF13559.6 CDI85529.1 - 0.036 14.3 1.2 0.15 12.4 1.2 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4129) zf-C2H2_9 PF16293.5 CDI85529.1 - 0.088 12.7 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) MCM_lid PF17855.1 CDI85529.1 - 0.94 9.9 4.9 0.26 11.7 0.4 2.3 3 0 0 3 3 3 0 MCM AAA-lid domain Enkurin PF13864.6 CDI85529.1 - 5 7.6 8.9 2.6 8.5 5.4 2.5 2 1 0 2 2 2 0 Calmodulin-binding Ctr PF04145.15 CDI85530.1 - 6.6 7.3 8.3 1.4 9.6 4.0 1.8 1 1 1 2 2 2 0 Ctr copper transporter family Amnionless PF14828.6 CDI85530.1 - 6.8 5.4 9.2 9 5.0 9.2 1.2 1 0 0 1 1 1 0 Amnionless RNA_pol_Rpc4 PF05132.14 CDI85530.1 - 7.7 6.9 12.0 2.8 8.4 2.7 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 Utp14 PF04615.13 CDI85531.1 - 8.4 4.8 78.8 1.1 7.8 43.6 2.2 2 0 0 2 2 2 0 Utp14 protein AF-4 PF05110.13 CDI85532.1 - 0.026 12.6 46.5 0.033 12.3 46.5 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Nop53 PF07767.11 CDI85532.1 - 0.11 11.9 29.5 0.13 11.6 29.5 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PAT1 PF09770.9 CDI85532.1 - 0.32 9.2 38.2 0.33 9.2 38.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AbLIM_anchor PF16182.5 CDI85532.1 - 0.36 10.6 26.2 0.45 10.3 26.2 1.2 1 0 0 1 1 1 0 Putative adherens-junction anchoring region of AbLIM Hamartin PF04388.12 CDI85532.1 - 0.49 9.0 29.9 0.57 8.8 29.9 1.0 1 0 0 1 1 1 0 Hamartin protein CCSAP PF15748.5 CDI85532.1 - 0.67 10.1 38.1 1 9.5 38.1 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CDK5_activator PF03261.15 CDI85532.1 - 1.8 8.0 22.0 2 7.9 22.0 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein SLC12 PF03522.15 CDI85532.1 - 2.5 7.0 26.7 2.9 6.8 26.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 AAA_23 PF13476.6 CDI85532.1 - 2.7 8.5 23.9 3.6 8.0 23.9 1.2 1 0 0 1 1 1 0 AAA domain LAP1C PF05609.12 CDI85532.1 - 2.7 7.0 31.2 3.1 6.8 31.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RIFIN PF02009.16 CDI85532.1 - 3.5 7.4 23.7 5.2 6.9 23.7 1.2 1 0 0 1 1 1 0 Rifin SOBP PF15279.6 CDI85532.1 - 3.9 8.0 31.6 4.7 7.7 31.6 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein ESM4 PF15952.5 CDI85532.1 - 4 7.8 36.8 5.7 7.3 36.8 1.1 1 0 0 1 1 1 0 Enhancer of split M4 family Exonuc_VII_L PF02601.15 CDI85532.1 - 5.1 6.6 30.4 6.8 6.2 30.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit RskA PF10099.9 CDI85532.1 - 5.9 7.1 39.0 0.17 12.2 21.4 2.8 1 1 1 2 2 2 0 Anti-sigma-K factor rskA PPP4R2 PF09184.11 CDI85532.1 - 9.1 5.8 22.2 11 5.5 22.2 1.1 1 0 0 1 1 1 0 PPP4R2 CAP_N PF01213.19 CDI85533.1 - 0.0049 16.4 17.6 0.0049 16.4 17.6 3.5 1 1 1 3 3 3 1 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 CDI85533.1 - 0.24 11.4 10.3 0.85 9.7 10.3 1.9 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Cytochrom_B558a PF05038.13 CDI85533.1 - 0.26 10.8 3.3 0.45 10.1 3.3 1.3 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit DUF2722 PF10846.8 CDI85534.1 - 9e-05 21.6 25.9 0.00019 20.5 7.2 10.7 5 3 4 10 10 10 2 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI85534.1 - 0.0011 18.9 0.0 0.0011 18.9 0.0 17.5 10 6 3 13 13 13 4 Unstructured region C-term to UIM in Ataxin3 DUF4834 PF16118.5 CDI85534.1 - 0.042 14.8 0.1 0.042 14.8 0.1 11.1 7 2 1 8 8 8 0 Domain of unknown function (DUF4834) SR-25 PF10500.9 CDI85534.1 - 0.35 10.5 133.5 0.0091 15.6 38.6 7.2 5 2 1 7 7 7 0 Nuclear RNA-splicing-associated protein RraA-like PF03737.15 CDI85534.1 - 2.6 8.2 6.9 0.22 11.7 0.4 2.5 2 1 0 2 2 2 0 Aldolase/RraA PROCT PF08084.11 CDI85535.1 - 0.039 13.9 0.1 0.07 13.1 0.1 1.3 1 0 0 1 1 1 0 PROCT (NUC072) domain Phostensin_N PF13916.6 CDI85535.1 - 5.1 7.5 7.6 1.8 9.0 0.8 3.3 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal NAM-associated PF14303.6 CDI85536.1 - 2.6e-05 25.0 3.2 2.6e-05 25.0 3.2 5.0 3 2 1 4 4 4 1 No apical meristem-associated C-terminal domain SUIM_assoc PF16619.5 CDI85536.1 - 0.0011 19.0 5.7 0.0011 19.0 5.7 6.0 4 2 1 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 Mak16 PF04874.14 CDI85536.1 - 9.1 7.0 11.9 0.94 10.1 2.7 2.9 3 0 0 3 3 3 0 Mak16 protein C-terminal region Nha1_C PF08619.10 CDI85536.1 - 9.7 5.3 43.2 0.031 13.5 9.0 3.3 3 0 0 3 3 3 0 Alkali metal cation/H+ antiporter Nha1 C terminus Caldesmon PF02029.15 CDI85537.1 - 0.0086 14.9 47.3 0.014 14.2 47.3 1.3 1 0 0 1 1 1 1 Caldesmon PSCyt3 PF07627.11 CDI85538.1 - 0.023 15.0 1.3 0.023 15.0 1.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1588) SR-25 PF10500.9 CDI85538.1 - 0.14 11.7 42.2 0.31 10.6 10.2 3.7 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein MAM33 PF02330.16 CDI85538.1 - 1 9.2 8.8 0.21 11.5 3.4 2.1 2 0 0 2 2 2 0 Mitochondrial glycoprotein Activator_LAG-3 PF11498.8 CDI85538.1 - 1.4 7.8 37.9 0.062 12.3 29.5 2.3 2 0 0 2 2 2 0 Transcriptional activator LAG-3 SpoIIP PF07454.11 CDI85538.1 - 2.1 7.7 8.3 1.3 8.4 3.0 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) SPX PF03105.19 CDI85538.1 - 3.2 7.6 24.0 8.3 6.2 24.0 1.7 1 1 0 1 1 1 0 SPX domain TFIIA PF03153.13 CDI85538.1 - 6.3 6.7 53.8 48 3.8 53.8 2.0 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ASD2 PF08687.11 CDI85538.1 - 6.4 6.2 16.7 1.7 8.1 3.4 2.4 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Tetraspanin PF00335.20 CDI85538.1 - 9.8 5.8 11.1 22 4.6 11.1 1.5 1 0 0 1 1 1 0 Tetraspanin family DUF4628 PF15429.6 CDI85539.1 - 0.011 15.4 13.1 0.011 15.4 13.1 3.1 1 1 1 3 3 3 0 Domain of unknown function (DUF4628) CobT PF06213.12 CDI85539.1 - 0.037 13.4 54.7 0.015 14.7 20.4 2.4 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF5523 PF17661.1 CDI85539.1 - 5.4 6.6 39.5 1.5 8.5 11.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) SID-1_RNA_chan PF13965.6 CDI85539.1 - 6.8 5.0 18.0 0.46 8.8 2.7 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DA1-like PF12315.8 CDI85540.1 - 1.1e-07 31.4 9.2 1.1e-07 31.4 9.2 4.3 2 1 2 4 4 3 2 Protein DA1 SR-25 PF10500.9 CDI85540.1 - 1.4e-06 28.1 55.3 0.0011 18.7 16.9 3.4 3 0 0 3 3 3 2 Nuclear RNA-splicing-associated protein Suf PF05843.14 CDI85540.1 - 0.0021 18.1 15.4 0.0021 18.1 15.4 3.8 3 1 0 3 3 2 1 Suppressor of forked protein (Suf) Pex14_N PF04695.13 CDI85540.1 - 0.0031 18.2 20.8 0.0031 18.2 20.8 5.1 4 2 0 4 4 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region SUIM_assoc PF16619.5 CDI85540.1 - 0.0076 16.3 3.5 0.0076 16.3 3.5 9.3 4 2 0 4 4 2 2 Unstructured region C-term to UIM in Ataxin3 Presenilin PF01080.17 CDI85540.1 - 0.019 13.7 60.4 0.067 11.9 21.2 3.2 3 0 0 3 3 3 0 Presenilin DUF2052 PF09747.9 CDI85540.1 - 0.07 13.3 47.5 0.4 10.8 15.9 3.2 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) SLC12 PF03522.15 CDI85540.1 - 0.12 11.4 50.4 0.49 9.4 15.7 3.1 3 0 0 3 3 3 0 Solute carrier family 12 BSMAP PF12280.8 CDI85540.1 - 0.13 12.4 32.6 0.27 11.4 9.4 3.5 3 0 0 3 3 3 0 Brain specific membrane anchored protein DUF5523 PF17661.1 CDI85540.1 - 0.21 11.2 45.0 0.41 10.3 13.1 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5523) DUF913 PF06025.12 CDI85540.1 - 0.23 10.4 33.8 0.27 10.2 9.4 3.2 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 CDI85540.1 - 0.27 11.2 45.2 0.39 10.7 13.8 3.2 3 0 0 3 3 3 0 Protein Family FAM60A PAT1 PF09770.9 CDI85540.1 - 0.4 8.9 77.5 0.56 8.4 40.6 2.3 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Connexin PF00029.19 CDI85540.1 - 0.55 10.0 37.2 0.17 11.6 8.4 3.4 3 0 0 3 3 3 0 Connexin GAGA_bind PF06217.12 CDI85540.1 - 0.83 9.9 40.1 0.48 10.7 11.8 3.1 3 0 0 3 3 3 0 GAGA binding protein-like family FAM76 PF16046.5 CDI85540.1 - 0.88 8.9 52.2 0.47 9.8 14.6 3.2 3 0 0 3 3 3 0 FAM76 protein Endostatin PF06482.11 CDI85540.1 - 0.91 8.9 47.5 0.76 9.2 16.1 3.1 3 0 0 3 3 3 0 Collagenase NC10 and Endostatin PNISR PF15996.5 CDI85540.1 - 1.5 9.1 70.5 2.9 8.1 0.7 3.4 3 0 0 3 3 3 0 Arginine/serine-rich protein PNISR Cwf_Cwc_15 PF04889.12 CDI85540.1 - 1.5 8.5 43.1 0.52 10.0 10.6 3.3 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein AAA_11 PF13086.6 CDI85540.1 - 1.9 8.2 53.3 3.3 7.4 22.4 3.1 3 0 0 3 3 3 0 AAA domain Raftlin PF15250.6 CDI85540.1 - 3.1 6.4 42.3 0.63 8.7 11.5 3.1 3 0 0 3 3 3 0 Raftlin DUF1387 PF07139.11 CDI85540.1 - 3.4 7.3 53.9 0.068 12.9 12.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1387) Vfa1 PF08432.10 CDI85540.1 - 4 7.7 54.3 1.2 9.4 16.8 3.3 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 Radical_SAM_N PF08497.10 CDI85540.1 - 6.4 5.9 24.1 0.93 8.7 4.6 2.6 3 0 0 3 3 3 0 Radical SAM N-terminal PPP4R2 PF09184.11 CDI85540.1 - 6.8 6.2 32.4 0.27 10.8 6.7 2.8 3 0 0 3 3 3 0 PPP4R2 Zip PF02535.22 CDI85540.1 - 8.9 5.4 37.6 0.76 8.9 7.9 3.0 3 0 0 3 3 3 0 ZIP Zinc transporter DUF4775 PF16001.5 CDI85541.1 - 1.2 8.4 26.5 1.5 8.1 26.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Coilin_N PF15862.5 CDI85541.1 - 2.7 7.8 10.9 67 3.3 0.0 2.2 2 0 0 2 2 2 0 Coilin N-terminus Utp14 PF04615.13 CDI85542.1 - 0.17 10.4 74.8 0.23 10.0 74.8 1.0 1 0 0 1 1 1 0 Utp14 protein DUF1467 PF07330.12 CDI85542.1 - 0.43 10.6 3.3 8.7 6.4 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1467) DUF913 PF06025.12 CDI85543.1 - 0.011 14.7 15.0 0.012 14.6 15.0 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 CDI85543.1 - 0.017 13.9 20.7 0.019 13.8 20.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Afi1 PF07792.12 CDI85543.1 - 0.09 13.3 23.8 0.13 12.8 23.8 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking V_ATPase_I PF01496.19 CDI85543.1 - 0.1 10.5 27.2 0.11 10.4 27.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI85543.1 - 0.12 11.4 21.3 0.13 11.3 21.3 1.0 1 0 0 1 1 1 0 CLN3 protein Rtf2 PF04641.12 CDI85543.1 - 0.18 11.2 22.6 0.2 11.0 22.6 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger SpoIIP PF07454.11 CDI85543.1 - 0.22 10.9 30.0 0.31 10.4 30.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RR_TM4-6 PF06459.12 CDI85543.1 - 0.24 11.2 28.4 0.28 11.0 28.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2828 PF11443.8 CDI85543.1 - 0.28 9.2 24.7 0.31 9.1 24.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CSG2 PF16965.5 CDI85543.1 - 0.43 9.5 15.5 0.46 9.4 15.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF3807 PF12720.7 CDI85543.1 - 0.66 10.2 40.1 0.75 10.0 40.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Kei1 PF08552.11 CDI85543.1 - 0.83 9.5 16.4 1.3 8.9 16.4 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Zip PF02535.22 CDI85543.1 - 0.99 8.6 15.7 1.1 8.4 15.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SLC12 PF03522.15 CDI85543.1 - 1 8.3 29.2 1.2 8.1 29.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 CDI85543.1 - 1.1 8.0 23.4 1.3 7.8 23.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Endostatin PF06482.11 CDI85543.1 - 1.1 8.6 25.9 1.3 8.4 25.9 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Presenilin PF01080.17 CDI85543.1 - 1.3 7.7 34.9 1.5 7.5 34.9 1.0 1 0 0 1 1 1 0 Presenilin HCO3_cotransp PF00955.21 CDI85543.1 - 1.4 7.6 14.9 1.5 7.5 14.9 1.0 1 0 0 1 1 1 0 HCO3- transporter family DUF2052 PF09747.9 CDI85543.1 - 1.8 8.7 29.3 2.1 8.4 29.3 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF2370 PF10176.9 CDI85543.1 - 2 8.0 15.4 2.3 7.8 15.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) CBP_BcsG PF11658.8 CDI85543.1 - 2.1 6.6 23.3 2.4 6.5 23.3 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG FAM60A PF15396.6 CDI85543.1 - 2.2 8.2 22.4 2.7 7.9 22.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A RP-C_C PF11800.8 CDI85543.1 - 2.4 8.2 22.1 2.9 7.9 22.1 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Gti1_Pac2 PF09729.9 CDI85543.1 - 2.6 8.1 24.1 3.2 7.8 24.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4366 PF14283.6 CDI85543.1 - 2.7 8.0 17.7 6.4 6.8 17.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) DUF966 PF06136.13 CDI85543.1 - 2.9 7.5 22.3 3.4 7.3 22.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Vfa1 PF08432.10 CDI85543.1 - 3.7 7.9 30.5 4.2 7.7 30.5 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Velvet PF11754.8 CDI85543.1 - 3.8 7.4 27.0 4.7 7.1 27.0 1.1 1 0 0 1 1 1 0 Velvet factor Piezo_RRas_bdg PF12166.8 CDI85543.1 - 4.1 6.6 20.2 4.7 6.4 20.2 1.0 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain CDC45 PF02724.14 CDI85543.1 - 4.1 5.6 26.5 4.9 5.3 26.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 CDI85543.1 - 5.7 6.9 24.2 6.5 6.7 24.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SID-1_RNA_chan PF13965.6 CDI85543.1 - 5.8 5.2 17.6 6.3 5.1 17.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 UPF0565 PF10561.9 CDI85543.1 - 6.1 5.9 16.6 6.7 5.8 16.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Sec62 PF03839.16 CDI85543.1 - 6.8 6.1 26.0 8.1 5.9 26.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Spore_coat_CotO PF14153.6 CDI85543.1 - 6.8 6.6 39.6 9.7 6.1 39.6 1.2 1 0 0 1 1 1 0 Spore coat protein CotO PAT1 PF09770.9 CDI85543.1 - 7 4.8 49.1 7.9 4.6 49.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4776 PF16003.5 CDI85543.1 - 7.1 5.5 26.0 8.4 5.3 26.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Hamartin PF04388.12 CDI85543.1 - 8.2 5.0 25.5 8.9 4.8 25.5 1.0 1 0 0 1 1 1 0 Hamartin protein Tim54 PF11711.8 CDI85543.1 - 8.3 5.1 25.6 12 4.5 25.6 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ctr PF04145.15 CDI85543.1 - 9 6.9 18.6 13 6.4 18.6 1.3 1 0 0 1 1 1 0 Ctr copper transporter family BORG_CEP PF14957.6 CDI85543.1 - 9.7 7.4 20.7 13 7.0 20.7 1.1 1 0 0 1 1 1 0 Cdc42 effector DUF2207 PF09972.9 CDI85544.1 - 0.15 10.8 4.8 0.18 10.5 4.0 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) FKS1_dom1 PF14288.6 CDI85544.1 - 0.97 9.8 13.4 0.59 10.5 7.1 2.1 2 0 0 2 2 2 0 1,3-beta-glucan synthase subunit FKS1, domain-1 UPF0054 PF02130.17 CDI85545.1 - 5.2e-07 29.5 0.0 5.2e-07 29.5 0.0 2.0 2 1 0 2 2 1 1 Uncharacterized protein family UPF0054 BAF1_ABF1 PF04684.13 CDI85545.1 - 6.5e-07 28.8 2.0 6.5e-07 28.8 2.0 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor ACPS PF01648.20 CDI85545.1 - 1.2e-06 28.6 10.5 7.6e-06 26.0 3.7 3.3 2 1 1 3 3 2 1 4'-phosphopantetheinyl transferase superfamily TFIIA PF03153.13 CDI85545.1 - 8.5e-06 26.0 28.9 1.2e-05 25.5 28.9 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SprA-related PF12118.8 CDI85545.1 - 0.00044 19.5 34.0 0.00066 18.9 34.0 1.2 1 0 0 1 1 1 1 SprA-related family SAPS PF04499.15 CDI85545.1 - 0.00073 18.4 1.9 0.00073 18.4 1.9 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein CNDH2_C PF16858.5 CDI85545.1 - 0.001 19.0 13.4 0.0014 18.6 13.4 1.1 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term Neur_chan_memb PF02932.16 CDI85545.1 - 0.001 19.2 5.3 0.0012 19.0 5.3 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region CobT PF06213.12 CDI85545.1 - 0.0019 17.6 21.1 0.0032 16.9 21.1 1.5 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Velvet PF11754.8 CDI85545.1 - 0.0043 17.0 6.6 0.0052 16.8 6.6 1.2 1 0 0 1 1 1 1 Velvet factor Activator_LAG-3 PF11498.8 CDI85545.1 - 0.0065 15.5 42.1 0.011 14.8 42.1 1.5 1 0 0 1 1 1 1 Transcriptional activator LAG-3 RIFIN PF02009.16 CDI85545.1 - 0.019 14.9 13.5 0.025 14.5 13.5 1.2 1 0 0 1 1 1 0 Rifin Tim54 PF11711.8 CDI85545.1 - 0.023 13.5 10.0 0.061 12.1 10.2 1.6 2 0 0 2 2 1 0 Inner membrane protein import complex subunit Tim54 Plasmodium_Vir PF05795.11 CDI85545.1 - 0.027 13.9 5.3 0.037 13.5 5.3 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PTPRCAP PF15713.5 CDI85545.1 - 0.035 14.4 18.4 0.067 13.5 18.4 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DcuA_DcuB PF03605.14 CDI85545.1 - 0.036 13.0 4.3 0.058 12.3 4.3 1.4 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DDHD PF02862.17 CDI85545.1 - 0.055 13.6 11.0 0.076 13.2 11.0 1.3 1 0 0 1 1 1 0 DDHD domain Cellulose_synt PF03552.14 CDI85545.1 - 0.074 11.5 4.5 0.098 11.1 4.5 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF913 PF06025.12 CDI85545.1 - 0.092 11.7 8.4 0.12 11.3 8.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 CDI85545.1 - 0.092 11.5 20.2 0.15 10.8 20.2 1.3 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 CDI85545.1 - 0.092 12.2 15.3 0.13 11.7 15.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CLN3 PF02487.17 CDI85545.1 - 0.11 11.5 9.1 0.16 11.0 9.1 1.3 1 0 0 1 1 1 0 CLN3 protein eIF-3_zeta PF05091.12 CDI85545.1 - 0.15 11.0 17.4 0.19 10.7 17.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PAT1 PF09770.9 CDI85545.1 - 0.17 10.1 27.1 0.21 9.8 27.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hamartin PF04388.12 CDI85545.1 - 0.2 10.3 12.9 0.27 9.9 12.9 1.1 1 0 0 1 1 1 0 Hamartin protein Band_3_cyto PF07565.13 CDI85545.1 - 0.32 10.8 14.6 0.53 10.0 14.6 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain HNOBA PF07701.14 CDI85545.1 - 0.33 10.4 10.8 0.51 9.7 10.8 1.3 1 0 0 1 1 1 0 Heme NO binding associated EOS1 PF12326.8 CDI85545.1 - 0.33 10.8 5.4 0.57 10.1 5.4 1.5 1 0 0 1 1 1 0 N-glycosylation protein DUF2052 PF09747.9 CDI85545.1 - 0.34 11.0 20.7 0.67 10.1 20.7 1.5 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SLC12 PF03522.15 CDI85545.1 - 0.35 9.9 15.5 0.5 9.3 15.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 BORG_CEP PF14957.6 CDI85545.1 - 0.38 11.9 8.1 0.64 11.2 8.1 1.4 1 0 0 1 1 1 0 Cdc42 effector FemAB PF02388.16 CDI85545.1 - 0.41 9.5 16.1 0.56 9.0 16.1 1.1 1 0 0 1 1 1 0 FemAB family PA26 PF04636.13 CDI85545.1 - 0.44 9.4 13.3 0.55 9.1 13.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Serinc PF03348.15 CDI85545.1 - 0.5 9.2 8.1 0.84 8.5 8.1 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF5427 PF10310.9 CDI85545.1 - 0.54 9.2 22.1 0.092 11.7 18.5 1.5 2 0 0 2 2 1 0 Family of unknown function (DUF5427) RR_TM4-6 PF06459.12 CDI85545.1 - 0.61 9.9 20.0 0.95 9.2 20.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF966 PF06136.13 CDI85545.1 - 0.69 9.6 12.3 0.92 9.2 12.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Med15 PF09606.10 CDI85545.1 - 0.8 8.3 37.4 1.1 7.8 37.4 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DDRGK PF09756.9 CDI85545.1 - 0.89 9.1 25.9 1.5 8.3 25.9 1.3 1 0 0 1 1 1 0 DDRGK domain DUF4638 PF15472.6 CDI85545.1 - 0.91 9.2 15.8 1.3 8.7 15.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) AAA_23 PF13476.6 CDI85545.1 - 0.91 10.0 18.6 1.5 9.3 18.6 1.3 1 0 0 1 1 1 0 AAA domain FAM60A PF15396.6 CDI85545.1 - 0.94 9.4 12.1 1.4 8.9 12.1 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Gti1_Pac2 PF09729.9 CDI85545.1 - 1 9.4 12.5 1.9 8.6 12.5 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family AUX_IAA PF02309.16 CDI85545.1 - 1.1 9.1 8.6 1.5 8.6 8.6 1.4 1 0 0 1 1 1 0 AUX/IAA family Kei1 PF08552.11 CDI85545.1 - 1.5 8.6 21.2 0.13 12.1 14.5 2.3 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4746 PF15928.5 CDI85545.1 - 1.5 8.1 14.9 2.3 7.6 14.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Peptidase_S64 PF08192.11 CDI85545.1 - 1.6 7.2 12.9 2.1 6.8 12.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF2207 PF09972.9 CDI85545.1 - 1.6 7.4 8.4 3 6.5 4.4 2.4 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) NEMP PF10225.9 CDI85545.1 - 1.8 8.2 6.3 3.5 7.2 6.3 1.5 1 0 0 1 1 1 0 NEMP family DUF1764 PF08576.10 CDI85545.1 - 1.9 9.4 14.3 4.1 8.4 14.3 1.6 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Lin-8 PF03353.15 CDI85545.1 - 2 7.9 21.3 2.9 7.4 21.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MMU163 PF17119.5 CDI85545.1 - 2.1 7.4 8.9 3.5 6.7 8.9 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Peroxin-13_N PF04088.13 CDI85545.1 - 2.2 8.5 7.9 4.6 7.5 7.9 1.6 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Connexin PF00029.19 CDI85545.1 - 2.5 7.8 15.2 4.7 6.9 15.2 1.4 1 0 0 1 1 1 0 Connexin RskA PF10099.9 CDI85545.1 - 2.7 8.2 43.2 0.15 12.3 18.7 3.2 2 1 1 3 3 2 0 Anti-sigma-K factor rskA Asp-B-Hydro_N PF05279.11 CDI85545.1 - 2.8 7.9 16.0 4.5 7.3 16.0 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4554 PF15091.6 CDI85545.1 - 3.1 6.6 22.9 4.3 6.1 22.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Paramyxo_ncap PF00973.19 CDI85545.1 - 3.3 6.5 11.9 4.1 6.2 11.9 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Exonuc_VII_L PF02601.15 CDI85545.1 - 3.3 7.2 21.7 4.6 6.7 21.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit GREB1 PF15782.5 CDI85545.1 - 3.7 4.5 18.6 4.4 4.3 18.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Sin_N PF04801.13 CDI85545.1 - 3.9 6.6 26.9 5.8 6.0 26.9 1.3 1 0 0 1 1 1 0 Sin-like protein conserved region CDC45 PF02724.14 CDI85545.1 - 4.6 5.4 16.9 6.2 5.0 16.9 1.1 1 0 0 1 1 1 0 CDC45-like protein YABBY PF04690.13 CDI85545.1 - 4.6 7.8 12.0 7.9 7.0 12.0 1.4 1 0 0 1 1 1 0 YABBY protein Coilin_N PF15862.5 CDI85545.1 - 5.3 6.8 18.7 11 5.8 18.7 1.5 1 0 0 1 1 1 0 Coilin N-terminus Hid1 PF12722.7 CDI85545.1 - 5.5 5.0 17.1 7.4 4.6 17.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Smg8_Smg9 PF10220.9 CDI85545.1 - 5.6 5.1 20.0 7.3 4.8 20.0 1.1 1 0 0 1 1 1 0 Smg8_Smg9 DUF2828 PF11443.8 CDI85545.1 - 6.5 4.7 17.7 8.6 4.3 17.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MAJIN PF15077.6 CDI85545.1 - 6.6 6.4 12.7 9.5 5.9 12.7 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Sporozoite_P67 PF05642.11 CDI85545.1 - 6.8 4.6 13.2 14 3.6 0.0 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen HCO3_cotransp PF00955.21 CDI85545.1 - 7.7 5.2 7.0 12 4.5 7.0 1.3 1 0 0 1 1 1 0 HCO3- transporter family FAM176 PF14851.6 CDI85545.1 - 8.5 6.0 18.1 1.6 8.3 13.3 2.1 2 0 0 2 2 2 0 FAM176 family Membralin PF09746.9 CDI85545.1 - 8.6 5.3 10.5 13 4.7 10.5 1.2 1 0 0 1 1 1 0 Tumour-associated protein Afi1 PF07792.12 CDI85545.1 - 8.7 6.8 18.3 16 6.0 18.3 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking ALMT PF11744.8 CDI85545.1 - 9.8 4.9 14.5 13 4.4 14.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter RskA PF10099.9 CDI85546.1 - 2.4e-05 24.7 58.4 3.2e-05 24.3 0.0 5.4 2 2 3 5 5 5 2 Anti-sigma-K factor rskA WD40 PF00400.32 CDI85547.1 - 4.6e-06 27.3 11.6 0.0033 18.2 0.4 6.2 7 0 0 7 7 7 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI85547.1 - 0.00021 21.6 0.0 1.3 9.3 0.0 3.8 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_60s PF00428.19 CDI85547.1 - 2.4 8.8 22.8 0.18 12.4 4.7 3.7 3 0 0 3 3 3 0 60s Acidic ribosomal protein Spt20 PF12090.8 CDI85548.1 - 0.32 10.6 4.3 0.34 10.5 4.3 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI85548.1 - 1.7 8.5 8.4 1.8 8.5 8.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3306 PF11748.8 CDI85548.1 - 8.4 7.3 16.1 14 6.6 15.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3306) TFIIA PF03153.13 CDI85549.1 - 0.001 19.2 24.3 0.001 19.2 24.3 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.19 CDI85549.1 - 0.0048 17.5 4.1 0.0048 17.5 4.1 5.9 5 2 0 5 5 2 1 60s Acidic ribosomal protein Collagen PF01391.18 CDI85549.1 - 0.0099 15.6 12.7 0.0099 15.6 12.7 1.9 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) BNIP2 PF12496.8 CDI85549.1 - 0.013 15.9 1.4 0.024 15.0 1.4 1.4 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 TERB2 PF15101.6 CDI85549.1 - 0.47 10.5 12.7 0.9 9.5 12.7 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 RR_TM4-6 PF06459.12 CDI85549.1 - 0.53 10.1 9.9 1.1 9.1 9.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PBP_sp32 PF07222.12 CDI85549.1 - 0.62 9.5 12.6 1.3 8.5 12.6 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 FancD2 PF14631.6 CDI85549.1 - 0.63 7.4 6.9 0.83 7.0 6.9 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease FCP1_C PF09309.10 CDI85549.1 - 0.73 9.7 13.2 0.12 12.2 9.1 1.7 2 0 0 2 2 2 0 FCP1, C-terminal Tim54 PF11711.8 CDI85549.1 - 0.76 8.5 7.2 1.3 7.7 7.2 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4446 PF14584.6 CDI85549.1 - 1 9.4 4.2 1.9 8.5 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) eIF-3_zeta PF05091.12 CDI85549.1 - 1.2 8.1 13.5 1.6 7.6 13.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4834 PF16118.5 CDI85549.1 - 1.9 9.5 13.2 4.7 8.2 13.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) HNOBA PF07701.14 CDI85549.1 - 2 7.8 9.4 3.1 7.2 9.4 1.2 1 0 0 1 1 1 0 Heme NO binding associated FAM176 PF14851.6 CDI85549.1 - 2.1 8.0 6.6 4.4 7.0 6.6 1.5 1 0 0 1 1 1 0 FAM176 family Band_3_cyto PF07565.13 CDI85549.1 - 2.2 8.0 7.3 3.5 7.3 7.3 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Neur_chan_memb PF02932.16 CDI85549.1 - 2.2 8.2 7.8 1.2 9.1 5.3 1.7 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.17 CDI85549.1 - 2.7 8.1 11.3 0.8 9.8 7.8 1.7 2 0 0 2 2 2 0 DDHD domain DUF4050 PF13259.6 CDI85549.1 - 2.8 8.2 12.0 6.5 7.0 5.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) SID-1_RNA_chan PF13965.6 CDI85549.1 - 2.9 6.2 4.7 0.67 8.3 1.4 1.4 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Spore_coat_CotO PF14153.6 CDI85549.1 - 3.5 7.5 18.2 7.2 6.5 18.2 1.4 1 0 0 1 1 1 0 Spore coat protein CotO Connexin PF00029.19 CDI85549.1 - 3.6 7.3 7.4 5.3 6.7 7.4 1.2 1 0 0 1 1 1 0 Connexin ALMT PF11744.8 CDI85549.1 - 3.6 6.3 7.8 5.5 5.7 7.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Serinc PF03348.15 CDI85549.1 - 4.5 6.1 6.1 8.3 5.2 6.1 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Bul1_N PF04425.12 CDI85549.1 - 5.4 5.6 10.2 7.6 5.2 10.2 1.1 1 0 0 1 1 1 0 Bul1 N terminus Paf1 PF03985.13 CDI85549.1 - 5.8 5.8 18.1 8.5 5.3 18.1 1.1 1 0 0 1 1 1 0 Paf1 DUF1980 PF09323.10 CDI85549.1 - 5.9 6.8 7.8 11 5.9 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) V_ATPase_I PF01496.19 CDI85549.1 - 6.4 4.6 10.5 9.8 4.0 10.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family THOC2_N PF16134.5 CDI85549.1 - 7.9 5.0 12.6 13 4.3 12.6 1.3 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus RIFIN PF02009.16 CDI85549.1 - 8 6.3 18.2 7.9 6.3 4.9 2.3 2 0 0 2 2 2 0 Rifin SpoIIP PF07454.11 CDI85549.1 - 8.4 5.8 13.2 6.9 6.0 11.5 1.6 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) TMEM174 PF15029.6 CDI85549.1 - 8.6 6.0 6.6 18 4.9 6.6 1.5 1 0 0 1 1 1 0 Transmembrane protein 174 DUF775 PF05603.12 CDI85549.1 - 8.8 5.8 12.5 22 4.5 12.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Ribosomal_60s PF00428.19 CDI85550.1 - 8.8 7.0 42.8 3.3 8.4 13.0 3.4 3 0 0 3 3 3 0 60s Acidic ribosomal protein SR-25 PF10500.9 CDI85551.1 - 0.00023 20.8 24.6 0.00023 20.8 24.6 12.9 8 4 1 10 10 10 4 Nuclear RNA-splicing-associated protein Trp_oprn_chp PF09534.10 CDI85551.1 - 0.00041 20.2 3.0 0.00041 20.2 3.0 8.9 8 1 0 9 9 9 3 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Sin_N PF04801.13 CDI85551.1 - 0.00056 19.2 0.3 0.00056 19.2 0.3 8.3 3 2 1 6 6 6 2 Sin-like protein conserved region SH3_2 PF07653.17 CDI85551.1 - 0.01 15.5 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain Pex14_N PF04695.13 CDI85552.1 - 0.013 16.1 11.0 0.017 15.8 11.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Nitroreductase PF00881.24 CDI85552.1 - 0.018 15.1 0.8 0.025 14.6 0.8 1.1 1 0 0 1 1 1 0 Nitroreductase family Zip PF02535.22 CDI85552.1 - 0.024 13.9 1.2 0.027 13.7 1.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter UCR_Fe-S_N PF10399.9 CDI85552.1 - 0.028 13.8 2.4 0.069 12.5 2.4 1.6 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Herpes_UL87 PF03043.14 CDI85552.1 - 0.03 12.8 0.2 0.042 12.3 0.2 1.2 1 0 0 1 1 1 0 Herpesvirus UL87 family DUF4366 PF14283.6 CDI85552.1 - 0.053 13.6 0.2 0.12 12.5 0.1 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) Presenilin PF01080.17 CDI85552.1 - 0.071 11.9 6.9 0.082 11.7 6.9 1.1 1 0 0 1 1 1 0 Presenilin GT87 PF09594.10 CDI85552.1 - 0.088 12.5 0.4 0.19 11.4 0.2 1.6 2 0 0 2 2 2 0 Glycosyltransferase family 87 Virul_Fac PF10139.9 CDI85552.1 - 0.096 10.9 4.9 0.12 10.6 4.9 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor ANAPC_CDC26 PF10471.9 CDI85552.1 - 0.098 13.5 25.2 0.33 11.8 9.6 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Hid1 PF12722.7 CDI85552.1 - 0.17 9.9 5.8 0.19 9.8 5.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PNISR PF15996.5 CDI85552.1 - 0.22 11.8 10.3 0.27 11.5 10.3 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR SLC12 PF03522.15 CDI85552.1 - 0.23 10.4 4.4 0.27 10.2 4.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI85552.1 - 0.23 11.5 6.4 0.29 11.1 6.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDK2AP PF09806.9 CDI85552.1 - 0.3 11.1 13.4 0.44 10.6 13.4 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein PsbQ PF05757.11 CDI85552.1 - 0.35 10.6 8.2 0.047 13.4 3.0 1.9 2 0 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) Baculo_LEF-10 PF07206.11 CDI85552.1 - 0.4 10.9 1.6 0.75 10.0 1.0 1.7 2 0 0 2 2 2 0 Baculovirus late expression factor 10 (LEF-10) Band_3_cyto PF07565.13 CDI85552.1 - 0.41 10.4 6.9 0.58 9.9 6.9 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MPM1 PF17234.2 CDI85552.1 - 1.1 9.5 7.5 1.9 8.7 2.0 2.0 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Eapp_C PF10238.9 CDI85552.1 - 1.4 9.0 8.5 2.7 8.0 2.6 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein RskA PF10099.9 CDI85552.1 - 2.1 8.6 17.0 1 9.7 3.0 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA BRF1 PF07741.13 CDI85552.1 - 2.2 8.7 7.2 5.2 7.5 1.2 2.1 2 0 0 2 2 2 0 Brf1-like TBP-binding domain HD_4 PF13328.6 CDI85552.1 - 2.3 7.9 10.3 0.078 12.7 0.7 2.2 2 1 0 2 2 2 0 HD domain DnaG_DnaB_bind PF08278.11 CDI85552.1 - 2.5 8.7 13.4 0.048 14.3 5.2 2.2 2 1 1 3 3 2 0 DNA primase DnaG DnaB-binding DUF3464 PF11947.8 CDI85552.1 - 4 7.2 7.2 24 4.6 0.1 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 PhnG PF06754.12 CDI85552.1 - 7.9 6.4 11.8 1.6 8.7 0.8 2.3 2 0 0 2 2 2 0 Phosphonate metabolism protein PhnG RskA PF10099.9 CDI85553.1 - 0.0059 16.9 8.4 0.0069 16.7 8.4 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA TALPID3 PF15324.6 CDI85553.1 - 0.038 11.7 10.8 0.041 11.6 10.8 1.0 1 0 0 1 1 1 0 Hedgehog signalling target CbiD PF01888.17 CDI85553.1 - 0.13 11.5 2.2 0.14 11.5 2.2 1.1 1 0 0 1 1 1 0 CbiD PKI PF02827.16 CDI85553.1 - 0.46 10.7 5.1 0.55 10.5 5.0 1.3 1 1 0 1 1 1 0 cAMP-dependent protein kinase inhibitor Spt20 PF12090.8 CDI85553.1 - 0.51 9.9 19.3 0.51 9.9 19.3 1.1 1 0 0 1 1 1 0 Spt20 family TIR-like PF10137.9 CDI85554.1 - 0.057 13.4 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain TMEM220 PF15071.6 CDI85554.1 - 0.25 12.1 4.1 0.37 11.6 0.0 3.3 2 0 0 2 2 2 0 Transmembrane family 220, helix DUF4079 PF13301.6 CDI85554.1 - 5.2 7.2 7.5 1.9 8.6 0.2 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF4079) SUIM_assoc PF16619.5 CDI85555.1 - 0.0054 16.8 3.5 0.0054 16.8 3.5 4.5 2 1 1 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 Activator_LAG-3 PF11498.8 CDI85555.1 - 0.006 15.6 27.1 0.006 15.6 27.1 2.3 2 0 0 2 2 2 2 Transcriptional activator LAG-3 PAT1 PF09770.9 CDI85555.1 - 0.058 11.7 16.8 0.07 11.4 16.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Collagen PF01391.18 CDI85556.1 - 2.3 8.1 13.2 75 3.2 11.2 3.0 2 1 0 2 2 2 0 Collagen triple helix repeat (20 copies) DUF4995 PF16386.5 CDI85557.1 - 2.8 8.0 6.3 1.1 9.4 0.9 2.9 2 1 0 2 2 2 0 Domain of unknown function Cactin_mid PF10312.9 CDI85558.1 - 1.5e-27 96.6 0.4 1.5e-27 96.6 0.4 2.8 3 1 0 3 3 3 1 Conserved mid region of cactin FliL PF03748.14 CDI85558.1 - 7.5 7.2 7.4 4.3 8.0 1.0 3.1 1 1 0 2 2 2 0 Flagellar basal body-associated protein FliL Ribosomal_60s PF00428.19 CDI85560.1 - 8.4 7.1 13.9 9.1 6.9 5.8 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein S1 PF00575.23 CDI85561.1 - 2.5e-05 24.5 0.2 18 5.7 0.1 6.1 6 1 0 6 6 6 1 S1 RNA binding domain N6_N4_Mtase PF01555.18 CDI85561.1 - 0.00069 19.4 4.3 4.9 6.8 1.5 5.5 5 2 0 5 5 5 2 DNA methylase Ribosomal_60s PF00428.19 CDI85561.1 - 0.0056 17.3 12.8 0.0056 17.3 12.8 22.2 20 4 1 21 21 21 3 60s Acidic ribosomal protein FAM104 PF15434.6 CDI85561.1 - 0.57 10.8 0.0 0.57 10.8 0.0 16.4 12 4 4 16 16 16 0 Family 104 SPX PF03105.19 CDI85561.1 - 3.5 7.4 0.0 0.054 13.4 6.6 11.9 2 2 5 8 8 8 0 SPX domain Utp14 PF04615.13 CDI85562.1 - 3.5e-05 22.6 29.3 3.5e-05 22.6 29.3 4.5 3 1 1 5 5 5 2 Utp14 protein BUD22 PF09073.10 CDI85562.1 - 9.7e-05 21.9 0.1 9.7e-05 21.9 0.1 5.0 2 2 2 4 4 4 1 BUD22 SR-25 PF10500.9 CDI85562.1 - 0.00022 20.9 3.3 0.00022 20.9 3.3 10.9 8 4 1 9 9 9 2 Nuclear RNA-splicing-associated protein ANAPC_CDC26 PF10471.9 CDI85562.1 - 0.015 16.1 2.0 0.015 16.1 2.0 16.1 12 2 1 14 14 14 0 Anaphase-promoting complex APC subunit CDC26 TAS2R PF05296.13 CDI85562.1 - 0.34 10.0 3.5 0.87 8.6 3.5 1.6 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) YppF PF14178.6 CDI85563.1 - 0.074 12.9 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 YppF-like protein TraT PF05818.12 CDI85565.1 - 0.00057 19.6 10.6 0.00065 19.4 10.6 1.1 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein DUF726 PF05277.12 CDI85565.1 - 0.0017 17.3 0.7 0.002 17.1 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF726) SPC22 PF04573.12 CDI85565.1 - 0.0039 16.7 0.7 0.0057 16.2 0.7 1.2 1 0 0 1 1 1 1 Signal peptidase subunit Activator_LAG-3 PF11498.8 CDI85565.1 - 0.0087 15.1 41.5 0.0093 15.0 41.5 1.1 1 0 0 1 1 1 1 Transcriptional activator LAG-3 Pex14_N PF04695.13 CDI85565.1 - 0.019 15.7 17.5 0.023 15.4 17.5 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2232 PF09991.9 CDI85565.1 - 0.074 12.2 2.8 0.087 12.0 2.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) TFIIA PF03153.13 CDI85565.1 - 0.075 13.0 38.9 0.083 12.9 38.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FHIPEP PF00771.20 CDI85565.1 - 0.085 11.3 7.4 0.098 11.1 7.4 1.1 1 0 0 1 1 1 0 FHIPEP family FPN1 PF06963.12 CDI85565.1 - 0.089 11.3 4.1 0.11 11.0 4.1 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Rxt3 PF08642.10 CDI85565.1 - 0.099 13.4 2.3 0.11 13.3 2.3 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 eIF-3_zeta PF05091.12 CDI85565.1 - 0.11 11.5 12.5 0.11 11.4 12.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SID-1_RNA_chan PF13965.6 CDI85565.1 - 0.13 10.7 2.8 0.14 10.5 2.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NEMP PF10225.9 CDI85565.1 - 0.14 11.8 5.3 0.18 11.4 5.3 1.1 1 0 0 1 1 1 0 NEMP family MMR1 PF08505.10 CDI85565.1 - 0.18 12.0 12.6 0.2 11.9 12.6 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF1980 PF09323.10 CDI85565.1 - 0.21 11.5 6.4 0.23 11.3 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) PA26 PF04636.13 CDI85565.1 - 0.23 10.4 9.8 0.25 10.2 9.8 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Sec62 PF03839.16 CDI85565.1 - 0.25 10.8 6.0 0.26 10.7 6.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 FAM176 PF14851.6 CDI85565.1 - 0.36 10.5 7.1 0.48 10.1 7.1 1.2 1 0 0 1 1 1 0 FAM176 family Tim54 PF11711.8 CDI85565.1 - 0.38 9.5 7.7 0.39 9.4 7.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 HemX PF04375.14 CDI85565.1 - 0.41 9.9 33.4 0.59 9.4 33.4 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4834 PF16118.5 CDI85565.1 - 0.42 11.6 10.2 0.57 11.2 10.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) AMP-binding PF00501.28 CDI85565.1 - 0.45 9.0 5.5 0.47 9.0 5.5 1.1 1 0 0 1 1 1 0 AMP-binding enzyme EIF4E-T PF10477.9 CDI85565.1 - 0.46 9.3 18.6 0.44 9.3 18.6 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DDHD PF02862.17 CDI85565.1 - 0.49 10.5 9.3 0.54 10.4 9.3 1.1 1 0 0 1 1 1 0 DDHD domain Ctr PF04145.15 CDI85565.1 - 0.51 10.9 5.5 0.61 10.7 5.5 1.1 1 0 0 1 1 1 0 Ctr copper transporter family SpoIIP PF07454.11 CDI85565.1 - 0.52 9.7 10.4 0.55 9.6 10.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 CDI85565.1 - 0.76 9.5 6.6 0.83 9.4 6.6 1.1 1 0 0 1 1 1 0 Connexin FAM199X PF15814.5 CDI85565.1 - 0.82 8.7 10.9 1.1 8.3 10.9 1.2 1 0 0 1 1 1 0 Protein family FAM199X Suf PF05843.14 CDI85565.1 - 0.9 9.5 14.0 1 9.3 14.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MAJIN PF15077.6 CDI85565.1 - 0.92 9.2 6.9 0.97 9.2 6.9 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Cellulose_synt PF03552.14 CDI85565.1 - 1.2 7.5 5.7 1.2 7.5 5.7 1.1 1 0 0 1 1 1 0 Cellulose synthase Presenilin PF01080.17 CDI85565.1 - 1.3 7.7 14.4 1.4 7.6 14.4 1.0 1 0 0 1 1 1 0 Presenilin TERB2 PF15101.6 CDI85565.1 - 1.4 8.9 17.3 1.8 8.6 17.3 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DcuA_DcuB PF03605.14 CDI85565.1 - 1.5 7.7 7.4 1.7 7.4 7.4 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Neur_chan_memb PF02932.16 CDI85565.1 - 1.6 8.7 8.3 1.7 8.6 8.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PAT1 PF09770.9 CDI85565.1 - 1.6 6.9 24.2 1.8 6.7 24.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EOS1 PF12326.8 CDI85565.1 - 1.8 8.5 3.7 1.9 8.4 3.7 1.2 1 0 0 1 1 1 0 N-glycosylation protein Paramyxo_ncap PF00973.19 CDI85565.1 - 1.8 7.4 9.4 1.9 7.3 9.4 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein SprA-related PF12118.8 CDI85565.1 - 2 7.5 32.3 2.4 7.2 32.3 1.0 1 0 0 1 1 1 0 SprA-related family Peptidase_S15 PF02129.18 CDI85565.1 - 2.1 7.9 12.9 2.4 7.7 12.9 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Herpes_glycop PF01528.16 CDI85565.1 - 2.2 7.0 4.9 2.6 6.8 4.9 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein M Band_3_cyto PF07565.13 CDI85565.1 - 2.2 8.0 11.4 2.6 7.8 11.4 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain AAA_23 PF13476.6 CDI85565.1 - 2.5 8.5 17.5 2.7 8.4 17.5 1.1 1 0 0 1 1 1 0 AAA domain Glt_symporter PF03616.14 CDI85565.1 - 2.6 6.7 5.6 3.6 6.2 5.6 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter Serinc PF03348.15 CDI85565.1 - 2.6 6.9 6.9 2.6 6.9 6.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Med15 PF09606.10 CDI85565.1 - 3 6.4 33.4 3.9 6.0 33.4 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4228 PF14009.6 CDI85565.1 - 3.4 8.0 8.9 4.4 7.6 8.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) HCO3_cotransp PF00955.21 CDI85565.1 - 3.5 6.3 4.5 3.6 6.3 4.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family Exonuc_VII_L PF02601.15 CDI85565.1 - 3.8 7.0 18.6 4.3 6.8 18.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CLN3 PF02487.17 CDI85565.1 - 4.2 6.3 9.0 4.7 6.2 9.0 1.1 1 0 0 1 1 1 0 CLN3 protein CSG2 PF16965.5 CDI85565.1 - 4.5 6.1 6.8 5.1 5.9 6.8 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Radical_SAM_N PF08497.10 CDI85565.1 - 5.1 6.2 8.4 5.8 6.1 8.4 1.0 1 0 0 1 1 1 0 Radical SAM N-terminal LMBR1 PF04791.16 CDI85565.1 - 5.2 5.8 5.9 5.2 5.9 5.9 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein FliP PF00813.20 CDI85565.1 - 5.7 6.8 5.3 5.9 6.7 5.3 1.2 1 0 0 1 1 1 0 FliP family UPF0560 PF10577.9 CDI85565.1 - 6.3 5.2 19.2 6.4 5.1 19.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 O-antigen_lig PF13425.6 CDI85565.1 - 6.3 5.5 4.6 7.1 5.3 4.6 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein N6_N4_Mtase PF01555.18 CDI85566.1 - 6e-05 22.9 0.4 22 4.6 0.0 4.1 3 1 0 3 3 3 1 DNA methylase RskA PF10099.9 CDI85566.1 - 0.0021 18.4 6.9 0.0021 18.4 6.9 7.4 1 1 5 6 6 6 3 Anti-sigma-K factor rskA PNISR PF15996.5 CDI85566.1 - 0.012 15.9 25.0 0.012 15.9 25.0 4.9 4 2 0 4 4 4 0 Arginine/serine-rich protein PNISR Oxidored_q3 PF00499.20 CDI85566.1 - 4.6 7.0 4.7 4.3 7.0 0.0 3.0 2 1 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 GSH_synth_ATP PF03917.17 CDI85567.1 - 2.4e-55 187.9 29.1 1.5e-29 102.9 30.6 3.9 2 2 0 2 2 2 2 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 CDI85567.1 - 1e-16 61.3 5.3 6.5e-15 55.4 5.3 3.1 1 1 0 1 1 1 1 Eukaryotic glutathione synthase Sin_N PF04801.13 CDI85567.1 - 0.00036 19.9 24.0 0.00036 19.9 24.0 4.7 3 1 0 4 4 4 2 Sin-like protein conserved region OmpH PF03938.14 CDI85567.1 - 0.0062 16.9 11.0 0.0062 16.9 11.0 6.8 6 1 0 7 7 7 1 Outer membrane protein (OmpH-like) Connexin PF00029.19 CDI85567.1 - 0.011 15.5 4.3 0.011 15.5 4.3 4.3 4 1 1 5 5 5 0 Connexin Otopetrin PF03189.13 CDI85567.1 - 0.077 11.8 13.2 0.055 12.3 5.9 3.2 2 1 0 2 2 2 0 Otopetrin Cellulose_synt PF03552.14 CDI85567.1 - 0.19 10.2 2.1 0.42 9.0 2.1 1.5 1 0 0 1 1 1 0 Cellulose synthase Ribosomal_60s PF00428.19 CDI85567.1 - 7.3 7.3 89.8 0.67 10.6 8.5 7.2 7 0 0 7 7 7 0 60s Acidic ribosomal protein RAWUL PF16207.5 CDI85569.1 - 0.0011 19.6 0.3 0.0019 18.9 0.3 1.4 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like DUF3337 PF11816.8 CDI85569.1 - 0.014 15.3 0.1 0.022 14.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) DUF2722 PF10846.8 CDI85569.1 - 0.018 14.0 0.9 0.018 14.0 0.9 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI85569.1 - 0.02 14.5 13.9 0.02 14.5 5.1 2.2 2 0 0 2 2 2 0 Spt20 family SUIM_assoc PF16619.5 CDI85569.1 - 0.022 14.8 19.9 0.082 13.0 8.1 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 SR-25 PF10500.9 CDI85571.1 - 0.0043 16.7 23.2 0.0043 16.7 23.2 12.4 11 3 1 12 12 12 7 Nuclear RNA-splicing-associated protein DUF4667 PF15700.5 CDI85571.1 - 0.019 15.0 0.7 0.019 15.0 0.7 12.0 5 4 5 11 11 11 0 Domain of unknown function (DUF4667) Tmemb_9 PF05434.11 CDI85572.1 - 3.4e-05 23.8 5.9 5.2e-05 23.2 5.9 1.2 1 0 0 1 1 1 1 TMEM9 V_ATPase_I PF01496.19 CDI85572.1 - 0.00034 18.7 6.7 0.00045 18.3 6.7 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family RSN1_TM PF13967.6 CDI85572.1 - 0.00091 19.0 0.8 0.0018 18.1 0.8 1.5 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport Pex24p PF06398.11 CDI85572.1 - 0.0016 17.5 1.6 0.0016 17.5 1.6 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF2722 PF10846.8 CDI85572.1 - 0.0032 16.5 11.1 0.0034 16.4 11.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) CBP_BcsG PF11658.8 CDI85572.1 - 0.0054 15.2 10.9 0.0054 15.2 10.9 1.8 1 1 1 2 2 2 1 Cellulose biosynthesis protein BcsG Neur_chan_memb PF02932.16 CDI85572.1 - 0.0092 16.1 1.2 0.012 15.7 1.2 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region OATP PF03137.20 CDI85572.1 - 0.0093 14.3 0.7 0.011 14.1 0.7 1.3 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family SID-1_RNA_chan PF13965.6 CDI85572.1 - 0.01 14.3 3.1 0.011 14.2 2.4 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4834 PF16118.5 CDI85572.1 - 0.011 16.7 13.1 0.033 15.1 13.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) MFS_1_like PF12832.7 CDI85572.1 - 0.013 14.3 0.0 0.023 13.6 0.0 1.4 1 1 0 1 1 1 0 MFS_1 like family YfhO PF09586.10 CDI85572.1 - 0.014 13.6 13.1 0.019 13.2 13.1 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF3402 PF11882.8 CDI85572.1 - 0.033 13.3 5.0 0.036 13.2 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) CitMHS PF03600.16 CDI85572.1 - 0.068 12.4 19.8 0.089 12.0 19.8 1.2 1 0 0 1 1 1 0 Citrate transporter CLN3 PF02487.17 CDI85572.1 - 0.074 12.1 8.5 0.058 12.4 7.4 1.4 1 1 0 1 1 1 0 CLN3 protein 7tm_1 PF00001.21 CDI85572.1 - 0.095 12.0 6.3 0.12 11.6 6.3 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) SKN1 PF03935.15 CDI85572.1 - 0.31 9.4 2.6 0.39 9.0 2.6 1.2 1 0 0 1 1 1 0 Beta-glucan synthesis-associated protein (SKN1) DivIC PF04977.15 CDI85572.1 - 0.42 10.4 16.0 1.1 9.1 16.0 1.7 1 0 0 1 1 1 0 Septum formation initiator VanZ PF04892.12 CDI85572.1 - 0.44 11.2 5.4 1.6 9.4 5.4 1.9 1 1 0 1 1 1 0 VanZ like family NUDE_C PF04880.13 CDI85572.1 - 0.61 10.5 13.8 0.71 10.3 13.8 1.0 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region PigN PF04987.14 CDI85572.1 - 0.64 8.8 11.4 0.31 9.9 8.1 1.8 1 1 1 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) Shisa PF13908.6 CDI85572.1 - 0.73 10.0 9.5 0.17 12.1 5.8 1.6 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator XRN_M PF17846.1 CDI85572.1 - 0.93 8.4 4.5 1.1 8.1 4.5 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Spt20 PF12090.8 CDI85572.1 - 0.94 9.0 26.1 1.5 8.4 26.1 1.2 1 0 0 1 1 1 0 Spt20 family Ni_hydr_CYTB PF01292.20 CDI85572.1 - 0.99 9.0 18.3 4.9 6.7 18.3 2.0 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 UPF0182 PF03699.13 CDI85572.1 - 1 7.4 16.8 1.3 7.1 16.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) PRA1 PF03208.19 CDI85572.1 - 1.1 8.9 14.0 2.1 8.0 14.0 1.6 1 1 0 1 1 1 0 PRA1 family protein Endomucin PF07010.12 CDI85572.1 - 1.5 8.8 14.6 1.9 8.4 14.6 1.2 1 0 0 1 1 1 0 Endomucin Sulf_transp PF04143.14 CDI85572.1 - 1.5 8.3 20.9 2.2 7.8 20.8 1.3 1 1 0 1 1 1 0 Sulphur transport DUF3169 PF11368.8 CDI85572.1 - 1.7 8.1 7.4 2.7 7.5 7.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3169) Herpes_LMP1 PF05297.11 CDI85572.1 - 1.8 7.7 4.8 2 7.5 4.8 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Comm PF15957.5 CDI85572.1 - 1.8 8.9 5.4 4 7.8 5.2 1.8 1 1 0 1 1 1 0 Commissureless DUF929 PF06053.11 CDI85572.1 - 2.2 7.5 7.7 3.8 6.8 7.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF929) MFS_Mycoplasma PF07672.13 CDI85572.1 - 2.3 7.4 7.9 3.4 6.9 7.9 1.4 1 1 0 1 1 1 0 Mycoplasma MFS transporter MMR1 PF08505.10 CDI85572.1 - 2.5 8.3 9.1 2.8 8.2 9.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Endonuc_Holl PF10107.9 CDI85572.1 - 2.7 7.8 6.5 4.6 7.1 6.5 1.4 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Arv1 PF04161.13 CDI85572.1 - 2.8 8.0 11.0 4.5 7.4 10.9 1.5 1 1 0 1 1 1 0 Arv1-like family TMEM51 PF15345.6 CDI85572.1 - 3.3 7.5 19.5 0.38 10.5 15.2 1.8 1 1 1 2 2 2 0 Transmembrane protein 51 WBP-1 PF11669.8 CDI85572.1 - 3.4 8.3 11.5 12 6.6 11.5 2.1 1 1 0 1 1 1 0 WW domain-binding protein 1 FAM176 PF14851.6 CDI85572.1 - 3.6 7.3 9.3 8.2 6.1 9.2 1.7 1 1 0 1 1 1 0 FAM176 family EI24 PF07264.11 CDI85572.1 - 5.1 7.3 12.4 8.9 6.5 12.4 1.5 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) 7tm_7 PF08395.12 CDI85572.1 - 5.3 6.1 17.5 6.4 5.9 17.5 1.1 1 0 0 1 1 1 0 7tm Chemosensory receptor Connexin PF00029.19 CDI85573.1 - 0.043 13.6 0.1 0.064 13.0 0.1 1.3 1 0 0 1 1 1 0 Connexin ATG13 PF10033.9 CDI85573.1 - 0.066 12.9 0.0 0.099 12.3 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 13 ANAPC_CDC26 PF10471.9 CDI85574.1 - 0.0026 18.6 31.1 0.07 14.0 7.1 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex APC subunit CDC26 Spt20 PF12090.8 CDI85574.1 - 0.0059 16.2 40.9 0.037 13.6 17.8 2.1 2 0 0 2 2 2 2 Spt20 family CNDH2_M PF16869.5 CDI85574.1 - 0.013 16.2 7.9 0.16 12.7 2.2 2.2 2 0 0 2 2 2 0 PF16858 Spc24 PF08286.11 CDI85574.1 - 0.022 15.0 6.7 0.16 12.2 0.1 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 UPF0560 PF10577.9 CDI85574.1 - 0.027 13.0 22.1 0.032 12.7 3.9 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 DUF2828 PF11443.8 CDI85574.1 - 0.035 12.2 2.6 0.048 11.8 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PIP5K PF01504.18 CDI85574.1 - 0.049 12.8 2.9 0.076 12.2 2.9 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Activator_LAG-3 PF11498.8 CDI85574.1 - 0.15 11.0 45.5 0.71 8.8 20.0 2.1 2 0 0 2 2 2 0 Transcriptional activator LAG-3 FAM176 PF14851.6 CDI85574.1 - 0.17 11.5 3.5 2.2 7.9 0.3 2.1 2 0 0 2 2 2 0 FAM176 family DUF3371 PF11851.8 CDI85574.1 - 0.3 12.2 16.2 2.3 9.3 3.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) AIF_C PF14721.6 CDI85574.1 - 0.41 11.0 9.4 1.2 9.5 0.2 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Band_3_cyto PF07565.13 CDI85574.1 - 0.5 10.1 10.1 3.1 7.5 1.5 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Pex14_N PF04695.13 CDI85574.1 - 0.67 10.6 25.2 1.4 9.6 4.4 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Suf PF05843.14 CDI85574.1 - 0.73 9.8 18.1 0.67 9.9 2.2 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) COX6A PF02046.15 CDI85574.1 - 0.8 10.2 6.0 1.6 9.2 0.0 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIa SARG PF15385.6 CDI85574.1 - 1 8.5 16.2 0.4 9.8 0.3 2.2 2 0 0 2 2 2 0 Specifically androgen-regulated gene protein DUF3381 PF11861.8 CDI85574.1 - 1.1 9.1 12.7 1.5 8.6 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Miff PF05644.11 CDI85574.1 - 1.1 8.8 12.5 1.4 8.5 1.1 2.1 2 0 0 2 2 2 0 Mitochondrial and peroxisomal fission factor Mff DUF4770 PF15994.5 CDI85574.1 - 1.3 9.3 11.8 2.8 8.1 3.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) DLIC PF05783.11 CDI85574.1 - 1.5 7.6 12.8 1.9 7.2 12.8 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) YabA PF06156.13 CDI85574.1 - 1.5 9.5 10.5 0.32 11.7 0.6 2.2 2 0 0 2 2 2 0 Initiation control protein YabA eIF-3_zeta PF05091.12 CDI85574.1 - 1.5 7.7 15.4 0.9 8.4 0.3 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Apc15p PF05841.11 CDI85574.1 - 1.7 9.5 18.0 4.3 8.1 6.5 2.4 2 0 0 2 2 2 0 Apc15p protein Peptidase_S49_N PF08496.10 CDI85574.1 - 3.2 7.8 10.8 3.2 7.8 0.5 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF5327 PF17261.2 CDI85574.1 - 3.2 8.5 20.3 4.3 8.1 3.6 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5327) DUF4834 PF16118.5 CDI85574.1 - 4.3 8.4 19.8 10 7.2 8.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TERB2 PF15101.6 CDI85574.1 - 5.7 6.9 21.1 4.1 7.4 7.8 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 EIF4E-T PF10477.9 CDI85574.1 - 6 5.6 21.3 0.65 8.8 5.6 2.0 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E FTO_NTD PF12933.7 CDI85574.1 - 6.6 5.9 10.0 1 8.5 1.0 2.1 2 0 0 2 2 2 0 FTO catalytic domain DUF702 PF05142.12 CDI85574.1 - 6.8 7.2 15.2 8.5 6.8 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) OmpH PF03938.14 CDI85574.1 - 7 7.0 33.4 0.67 10.3 9.1 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF1151 PF06625.11 CDI85574.1 - 7.2 6.6 22.9 0.23 11.4 5.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1151) DUF4820 PF16091.5 CDI85574.1 - 7.6 5.8 12.4 5 6.4 3.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF775 PF05603.12 CDI85574.1 - 7.9 6.0 19.4 2 7.9 2.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF775) CIAPIN1 PF05093.13 CDI85574.1 - 8.2 7.0 8.7 18 5.9 0.8 2.2 2 0 0 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Peroxin-13_N PF04088.13 CDI85574.1 - 9.5 6.5 7.5 11 6.3 1.7 2.1 2 0 0 2 2 2 0 Peroxin 13, N-terminal region RLL PF10036.9 CDI85574.1 - 9.8 5.9 20.0 5.6 6.7 8.3 2.1 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein CDC45 PF02724.14 CDI85575.1 - 0.74 8.0 25.0 0.8 7.9 25.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI85575.1 - 0.84 8.3 29.0 0.89 8.3 29.0 1.0 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI85575.1 - 1.5 8.6 25.3 1.8 8.4 25.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.6 CDI85575.1 - 2 8.4 18.5 2.3 8.2 18.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CCSAP PF15748.5 CDI85575.1 - 2.9 8.0 26.2 3.3 7.8 26.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated YscJ_FliF_C PF08345.11 CDI85575.1 - 3.4 8.0 26.2 4.8 7.5 26.2 1.2 1 0 0 1 1 1 0 Flagellar M-ring protein C-terminal Vfa1 PF08432.10 CDI85575.1 - 4 7.7 28.2 4.9 7.4 28.2 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SLC12 PF03522.15 CDI85575.1 - 4.5 6.2 27.1 5 6.0 27.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 AAA_11 PF13086.6 CDI85575.1 - 4.7 6.9 24.7 5.5 6.7 24.7 1.1 1 0 0 1 1 1 0 AAA domain VIR_N PF15912.5 CDI85575.1 - 5.2 6.6 20.9 5.9 6.4 20.9 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Phage_GPO PF05929.11 CDI85575.1 - 5.6 6.5 25.6 5.8 6.5 25.6 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase TFIIA PF03153.13 CDI85575.1 - 5.6 6.8 53.5 7.2 6.5 53.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI85575.1 - 5.7 6.9 18.2 6.7 6.7 18.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region V_ATPase_I PF01496.19 CDI85575.1 - 6.4 4.6 24.1 7.1 4.4 24.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4045 PF13254.6 CDI85575.1 - 6.4 6.3 21.9 6.9 6.2 21.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) MID_MedPIWI PF18296.1 CDI85575.1 - 6.4 6.5 22.8 7.4 6.3 22.8 1.0 1 0 0 1 1 1 0 MID domain of medPIWI DDRGK PF09756.9 CDI85575.1 - 6.8 6.2 35.3 11 5.5 35.3 1.4 1 0 0 1 1 1 0 DDRGK domain DUF913 PF06025.12 CDI85575.1 - 6.8 5.5 14.4 9.1 5.1 14.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PA26 PF04636.13 CDI85575.1 - 6.9 5.5 22.0 7.8 5.3 22.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DDHD PF02862.17 CDI85575.1 - 7.2 6.7 21.4 10 6.2 21.4 1.2 1 0 0 1 1 1 0 DDHD domain Exonuc_VII_L PF02601.15 CDI85575.1 - 8.9 5.8 28.1 10 5.6 28.1 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Asp-B-Hydro_N PF05279.11 CDI85575.1 - 9.7 6.2 26.0 12 5.9 26.0 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region AF-4 PF05110.13 CDI85576.1 - 0.0013 16.9 17.2 0.0016 16.7 17.2 1.1 1 0 0 1 1 1 1 AF-4 proto-oncoprotein BRF1 PF07741.13 CDI85576.1 - 0.0024 18.2 0.5 0.0029 17.9 0.5 1.3 1 0 0 1 1 1 1 Brf1-like TBP-binding domain TFIIA PF03153.13 CDI85576.1 - 0.0029 17.7 26.9 0.0034 17.4 26.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF1645 PF07816.11 CDI85576.1 - 0.0096 16.5 5.5 0.012 16.2 5.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1645) Med15 PF09606.10 CDI85576.1 - 0.092 11.4 25.7 0.11 11.2 25.7 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4667 PF15700.5 CDI85576.1 - 0.14 12.3 12.0 0.23 11.5 12.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4667) CemA PF03040.14 CDI85576.1 - 0.37 10.7 6.5 0.48 10.3 6.5 1.2 1 0 0 1 1 1 0 CemA family Exonuc_VII_L PF02601.15 CDI85576.1 - 0.4 10.2 15.7 0.4 10.2 15.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit APG9 PF04109.16 CDI85576.1 - 0.51 9.3 6.5 0.69 8.9 6.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg9 FHIPEP PF00771.20 CDI85576.1 - 0.6 8.5 11.6 0.7 8.3 11.6 1.1 1 0 0 1 1 1 0 FHIPEP family HI0933_like PF03486.14 CDI85576.1 - 0.67 8.6 11.1 0.77 8.4 11.1 1.1 1 0 0 1 1 1 0 HI0933-like protein LMBR1 PF04791.16 CDI85576.1 - 1.1 8.1 7.8 1.1 8.1 7.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein ALMT PF11744.8 CDI85576.1 - 2.9 6.6 9.4 3.4 6.4 9.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter TfuA PF07812.12 CDI85576.1 - 7.3 6.3 5.5 2.3 8.0 0.6 2.0 1 1 1 2 2 2 0 TfuA-like protein ThiF PF00899.21 CDI85577.1 - 0.0035 16.7 0.9 0.0035 16.7 0.9 2.1 1 1 0 2 2 2 1 ThiF family SUIM_assoc PF16619.5 CDI85577.1 - 0.017 15.2 10.4 0.017 15.2 10.4 9.4 6 3 1 7 7 7 0 Unstructured region C-term to UIM in Ataxin3 SpoIIP PF07454.11 CDI85579.1 - 0.00035 20.1 4.9 0.00036 20.1 4.9 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) TFIIA PF03153.13 CDI85579.1 - 0.0037 17.3 20.1 0.0037 17.3 20.1 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 CDI85579.1 - 0.0041 15.1 11.8 0.0047 14.9 11.8 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family TYW3 PF02676.14 CDI85579.1 - 0.0044 16.4 0.4 0.0061 16.0 0.4 1.2 1 0 0 1 1 1 1 Methyltransferase TYW3 SID-1_RNA_chan PF13965.6 CDI85579.1 - 0.014 13.8 2.7 0.015 13.7 2.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PIP5K PF01504.18 CDI85579.1 - 0.02 14.1 2.8 0.025 13.8 2.8 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase CLN3 PF02487.17 CDI85579.1 - 0.055 12.5 4.8 0.067 12.2 4.8 1.1 1 0 0 1 1 1 0 CLN3 protein T2SSC PF11356.8 CDI85579.1 - 0.11 12.4 5.9 0.19 11.7 5.9 1.3 1 0 0 1 1 1 0 Type II secretion system protein C Peptidase_S49_N PF08496.10 CDI85579.1 - 0.13 12.4 7.3 0.19 11.8 7.3 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal YABBY PF04690.13 CDI85579.1 - 0.14 12.7 4.4 0.17 12.4 4.4 1.2 1 0 0 1 1 1 0 YABBY protein Connexin PF00029.19 CDI85579.1 - 0.28 10.9 5.6 0.41 10.4 5.6 1.2 1 0 0 1 1 1 0 Connexin Neur_chan_memb PF02932.16 CDI85579.1 - 0.42 10.6 6.2 0.57 10.2 6.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EMC3_TMCO1 PF01956.16 CDI85579.1 - 0.47 10.2 7.6 0.66 9.7 7.6 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like SLATT_6 PF18169.1 CDI85579.1 - 0.77 9.3 5.6 0.99 9.0 5.6 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 DUF1180 PF06679.12 CDI85579.1 - 0.86 10.0 9.9 0.38 11.1 4.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) CemA PF03040.14 CDI85579.1 - 2.2 8.2 10.0 3 7.7 10.0 1.1 1 0 0 1 1 1 0 CemA family XK-related PF09815.9 CDI85579.1 - 3.4 6.6 9.9 3.2 6.7 9.2 1.3 1 1 0 1 1 1 0 XK-related protein Baculo_11_kDa PF06143.11 CDI85579.1 - 5.9 6.5 12.3 0.57 9.8 2.8 3.0 2 1 0 2 2 2 0 Baculovirus 11 kDa family DUF5523 PF17661.1 CDI85580.1 - 0.018 14.7 23.6 0.021 14.5 23.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Presenilin PF01080.17 CDI85580.1 - 0.51 9.0 29.8 0.63 8.7 29.8 1.0 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI85580.1 - 0.69 9.9 19.6 0.9 9.5 19.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF4407 PF14362.6 CDI85580.1 - 2.3 7.5 31.5 2.7 7.3 31.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PNISR PF15996.5 CDI85580.1 - 2.9 8.1 34.1 3.8 7.7 34.1 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR cwf18 PF08315.12 CDI85580.1 - 3.1 8.5 23.7 4.3 8.0 23.7 1.2 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor FAM217 PF15344.6 CDI85580.1 - 3.7 7.4 26.5 4.3 7.2 26.5 1.1 1 0 0 1 1 1 0 FAM217 family DUF4820 PF16091.5 CDI85580.1 - 4.3 6.6 19.7 6.8 6.0 19.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) CAML PF14963.6 CDI85580.1 - 4.6 7.3 12.8 5.4 7.1 12.8 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand SLC12 PF03522.15 CDI85580.1 - 5.3 6.0 27.3 6.9 5.6 27.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 AUX_IAA PF02309.16 CDI85580.1 - 5.7 6.7 17.6 7.4 6.3 17.6 1.2 1 0 0 1 1 1 0 AUX/IAA family Hid1 PF12722.7 CDI85580.1 - 6 4.9 26.4 7.1 4.6 26.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Gti1_Pac2 PF09729.9 CDI85580.1 - 9.6 6.3 28.2 2.4 8.2 15.1 2.0 1 1 1 2 2 2 0 Gti1/Pac2 family AAA_2 PF07724.14 CDI85581.1 - 6.5e-39 133.8 0.1 5.4e-38 130.8 0.1 2.1 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.9 CDI85581.1 - 4.2e-16 58.8 0.1 1.2e-15 57.3 0.1 1.8 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CDI85581.1 - 6.9e-09 35.8 0.1 2.3e-08 34.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CDI85581.1 - 2.5e-08 34.4 0.0 6.5e-08 33.1 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CDI85581.1 - 1.4e-07 31.4 0.0 2.6e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 CDI85581.1 - 7.9e-05 22.0 0.0 0.0002 20.7 0.0 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 CDI85581.1 - 0.00083 19.8 0.1 0.0031 17.9 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CDI85581.1 - 0.0023 17.7 0.0 0.005 16.6 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Torsin PF06309.11 CDI85581.1 - 0.0023 18.0 0.0 0.0078 16.3 0.0 1.8 2 0 0 2 2 2 1 Torsin AAA_18 PF13238.6 CDI85581.1 - 0.003 18.1 0.0 0.018 15.6 0.0 2.2 2 1 1 3 3 3 1 AAA domain ResIII PF04851.15 CDI85581.1 - 0.0057 16.7 0.0 0.24 11.4 0.0 2.6 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit RsgA_GTPase PF03193.16 CDI85581.1 - 0.0061 16.5 0.0 0.15 12.0 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase DNA_pol3_delta2 PF13177.6 CDI85581.1 - 0.0065 16.3 0.0 0.034 13.9 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 CDI85581.1 - 0.012 15.7 0.0 0.03 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 CDI85581.1 - 0.022 14.9 0.0 0.081 13.1 0.0 1.9 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 CDI85581.1 - 0.027 14.2 0.0 0.095 12.4 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_22 PF13401.6 CDI85581.1 - 0.038 14.3 0.2 1.5 9.1 0.1 2.7 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CDI85581.1 - 0.041 14.4 0.0 0.067 13.7 0.0 1.6 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 CDI85581.1 - 0.045 14.2 0.6 0.35 11.3 0.6 2.3 1 1 0 1 1 1 0 RNA helicase TIP49 PF06068.13 CDI85581.1 - 0.073 12.3 0.2 0.21 10.8 0.1 1.8 2 0 0 2 2 2 0 TIP49 P-loop domain DUF815 PF05673.13 CDI85581.1 - 0.074 12.2 0.0 0.2 10.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) T2SSE PF00437.20 CDI85581.1 - 0.081 12.0 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein PduV-EutP PF10662.9 CDI85581.1 - 0.088 12.5 0.0 0.51 10.1 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_3 PF07726.11 CDI85581.1 - 0.13 12.2 0.0 6.6 6.6 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 CDI85581.1 - 0.19 11.8 1.6 0.58 10.2 0.6 2.4 2 1 0 2 2 2 0 Helicase HerA, central domain RecX PF02631.16 CDI85581.1 - 1.2 9.6 4.5 7.3 7.1 0.6 2.4 2 0 0 2 2 2 0 RecX family DUF3295 PF11702.8 CDI85582.1 - 0.23 10.8 26.2 0.24 10.7 26.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) PAT1 PF09770.9 CDI85582.1 - 1.3 7.2 52.8 1.3 7.2 52.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Bul1_N PF04425.12 CDI85582.1 - 2.3 6.9 23.2 2.6 6.7 23.2 1.3 1 0 0 1 1 1 0 Bul1 N terminus CDC27 PF09507.10 CDI85582.1 - 2.4 7.4 33.0 3 7.2 33.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Neur_chan_memb PF02932.16 CDI85582.1 - 2.5 8.1 29.1 3.1 7.8 29.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ASC PF00858.24 CDI85582.1 - 2.5 7.0 18.2 2.6 6.9 18.2 1.2 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel MDM10 PF12519.8 CDI85582.1 - 3.4 6.4 28.3 3.6 6.4 28.3 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF4192 PF13830.6 CDI85582.1 - 3.8 7.5 11.3 5.3 7.0 11.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) Peptidase_S64 PF08192.11 CDI85582.1 - 3.8 5.9 26.5 3.9 5.8 26.5 1.2 1 0 0 1 1 1 0 Peptidase family S64 DUF908 PF06012.12 CDI85582.1 - 8.4 5.7 24.1 10 5.4 24.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Sec62 PF03839.16 CDI85584.1 - 0.077 12.5 12.4 0.082 12.4 12.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 CDI85584.1 - 0.079 11.7 25.1 0.082 11.7 25.1 1.0 1 0 0 1 1 1 0 Presenilin His_Phos_2 PF00328.22 CDI85584.1 - 0.081 12.3 11.3 0.084 12.2 11.3 1.0 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) DUF2076 PF09849.9 CDI85584.1 - 0.23 11.5 36.1 0.26 11.3 36.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) FAM60A PF15396.6 CDI85584.1 - 0.52 10.3 20.0 0.71 9.8 20.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A ASD2 PF08687.11 CDI85584.1 - 0.58 9.7 22.6 0.68 9.4 22.6 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Senescence_reg PF04520.13 CDI85584.1 - 0.99 10.2 19.1 1.2 10.0 19.1 1.1 1 0 0 1 1 1 0 Senescence regulator Mcm10 PF09332.11 CDI85584.1 - 0.99 8.8 25.5 1.1 8.6 25.5 1.0 1 0 0 1 1 1 0 Mcm10 replication factor SLC12 PF03522.15 CDI85584.1 - 1 8.3 23.0 1 8.3 23.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 RP-C_C PF11800.8 CDI85584.1 - 1.1 9.3 15.9 1.4 9.0 15.9 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Suf PF05843.14 CDI85584.1 - 1.4 8.9 29.6 1.7 8.6 29.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF5427 PF10310.9 CDI85584.1 - 1.6 7.6 23.4 1.9 7.3 23.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Hid1 PF12722.7 CDI85584.1 - 1.8 6.6 23.6 1.8 6.6 23.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 CDI85584.1 - 1.9 8.5 18.4 2.2 8.3 18.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PA26 PF04636.13 CDI85584.1 - 1.9 7.3 16.9 2 7.2 16.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF1387 PF07139.11 CDI85584.1 - 2.2 7.9 23.3 2.5 7.7 23.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Zip PF02535.22 CDI85584.1 - 2.4 7.3 13.0 2.8 7.1 13.0 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 CDI85584.1 - 2.8 6.1 18.3 3.1 6.0 18.3 1.0 1 0 0 1 1 1 0 CDC45-like protein DAG_kinase_N PF14513.6 CDI85584.1 - 3 8.0 20.7 3.7 7.7 20.7 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus MRP-S26 PF14943.6 CDI85584.1 - 3.3 7.6 22.4 4.4 7.2 22.4 1.1 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 PAT1 PF09770.9 CDI85584.1 - 3.5 5.8 33.2 3.9 5.6 33.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF908 PF06012.12 CDI85584.1 - 4.2 6.7 22.0 4.9 6.5 22.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Lin-8 PF03353.15 CDI85584.1 - 5.1 6.6 25.1 6.5 6.2 25.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist O-antigen_lig PF13425.6 CDI85584.1 - 5.4 5.7 11.0 5.7 5.6 11.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PNISR PF15996.5 CDI85584.1 - 6.2 7.0 27.5 7.5 6.8 27.5 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF2828 PF11443.8 CDI85584.1 - 6.9 4.6 16.7 8.5 4.3 16.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF966 PF06136.13 CDI85584.1 - 7.1 6.2 21.7 8.5 6.0 21.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) RR_TM4-6 PF06459.12 CDI85584.1 - 7.9 6.2 23.3 9.3 6.0 23.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spore_coat_CotO PF14153.6 CDI85584.1 - 8.7 6.2 26.7 12 5.8 26.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DUF2951 PF11166.8 CDI85585.1 - 5.4 7.3 13.9 0.28 11.4 3.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) DUF1387 PF07139.11 CDI85585.1 - 5.5 6.6 22.3 6.6 6.4 22.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) PhosphMutase PF10143.9 CDI85585.1 - 5.6 6.8 7.0 1.5 8.7 1.0 2.3 1 1 0 2 2 2 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase DUF2183 PF09949.9 CDI85587.1 - 0.013 15.9 0.1 0.075 13.4 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2183) DDHD PF02862.17 CDI85587.1 - 0.026 14.7 2.0 0.042 14.0 2.0 1.3 1 0 0 1 1 1 0 DDHD domain PAT1 PF09770.9 CDI85587.1 - 0.061 11.6 17.5 0.085 11.1 17.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CPSF100_C PF13299.6 CDI85587.1 - 0.32 11.2 6.1 0.56 10.4 6.1 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal eIF-3_zeta PF05091.12 CDI85587.1 - 0.33 9.9 10.9 0.56 9.1 10.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SpoIIP PF07454.11 CDI85587.1 - 0.47 9.9 7.2 0.72 9.3 7.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TFIIA PF03153.13 CDI85587.1 - 0.55 10.2 28.6 0.91 9.5 28.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI85587.1 - 0.61 10.1 3.1 0.99 9.4 3.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EPL1 PF10513.9 CDI85587.1 - 0.81 10.1 8.8 1.4 9.3 8.8 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF2828 PF11443.8 CDI85587.1 - 1.3 7.1 6.2 1.8 6.5 6.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CLN3 PF02487.17 CDI85587.1 - 1.3 8.0 4.7 13 4.6 6.8 1.5 2 0 0 2 2 2 0 CLN3 protein Borrelia_P83 PF05262.11 CDI85587.1 - 1.5 7.2 7.5 2.1 6.7 7.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein CSG2 PF16965.5 CDI85587.1 - 1.6 7.6 4.5 2.4 7.0 4.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Connexin PF00029.19 CDI85587.1 - 2.1 8.1 5.0 3.3 7.4 5.0 1.2 1 0 0 1 1 1 0 Connexin Pex14_N PF04695.13 CDI85587.1 - 3.1 8.5 22.7 0.36 11.5 17.7 2.0 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Suf PF05843.14 CDI85587.1 - 3.3 7.6 11.5 6 6.8 11.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Tim54 PF11711.8 CDI85587.1 - 4.1 6.1 9.0 6.5 5.4 9.0 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Membralin PF09746.9 CDI85587.1 - 4.3 6.3 5.3 6.1 5.8 5.3 1.1 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 CDI85587.1 - 4.6 5.9 12.8 7.1 5.3 12.8 1.2 1 0 0 1 1 1 0 Presenilin eIF3_subunit PF08597.10 CDI85587.1 - 4.7 7.1 12.5 7.7 6.4 12.5 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit ALMT PF11744.8 CDI85587.1 - 6.7 5.4 7.2 9.9 4.9 7.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4834 PF16118.5 CDI85587.1 - 8.1 7.5 9.6 18 6.4 9.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Folate_carrier PF01770.18 CDI85587.1 - 9.3 4.9 5.8 14 4.3 5.8 1.2 1 0 0 1 1 1 0 Reduced folate carrier NAD_Gly3P_dh_N PF01210.23 CDI85588.1 - 5.9e-42 143.3 0.0 8.9e-42 142.7 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 CDI85588.1 - 3.4e-29 102.0 0.1 6.1e-29 101.1 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus PfkB PF00294.24 CDI85589.1 - 1.6e-42 145.9 5.6 1.4e-36 126.3 2.2 2.5 1 1 1 2 2 2 2 pfkB family carbohydrate kinase HEAT PF02985.22 CDI85590.1 - 0.00028 20.9 18.8 1.3 9.5 0.0 8.3 7 0 0 7 7 7 4 HEAT repeat HEAT_EZ PF13513.6 CDI85590.1 - 0.53 10.8 0.0 0.53 10.8 0.0 9.9 10 2 3 13 13 13 0 HEAT-like repeat HEAT_2 PF13646.6 CDI85590.1 - 0.96 9.9 30.5 0.11 12.8 1.1 7.8 7 3 2 10 10 10 0 HEAT repeats HECT PF00632.25 CDI85592.1 - 9.4e-34 117.3 0.0 8.9e-21 74.7 0.0 2.3 1 1 1 2 2 2 2 HECT-domain (ubiquitin-transferase) Ank PF00023.30 CDI85592.1 - 2.9e-07 30.6 0.1 0.038 14.5 0.1 4.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 CDI85592.1 - 7.2e-07 29.6 0.4 0.016 15.8 0.0 4.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDI85592.1 - 3.9e-06 27.4 0.0 0.00027 21.5 0.0 3.5 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDI85592.1 - 1.7e-05 25.0 0.3 0.59 10.5 0.0 4.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Spt20 PF12090.8 CDI85592.1 - 0.0009 18.9 0.5 0.0009 18.9 0.5 15.4 11 2 3 14 14 14 6 Spt20 family M20_dimer PF07687.14 CDI85592.1 - 0.26 11.2 1.9 3.8 7.5 2.2 2.5 2 0 0 2 2 2 0 Peptidase dimerisation domain DUF4698 PF15769.5 CDI85593.1 - 1.8e-05 24.0 0.4 1.8e-05 24.0 0.4 6.5 5 2 1 6 6 6 1 Domain of unknown function (DUF4698) SR-25 PF10500.9 CDI85593.1 - 3.6e-05 23.5 6.8 3.6e-05 23.5 6.8 11.7 6 4 5 12 12 12 2 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI85593.1 - 0.0022 18.3 22.0 0.0022 18.3 22.0 18.4 1 1 11 12 12 12 1 Anti-sigma-K factor rskA DUF755 PF05501.11 CDI85594.1 - 0.0033 17.7 4.7 0.0033 17.7 4.7 9.2 6 3 1 7 7 7 1 Domain of unknown function (DUF755) FapA PF03961.13 CDI85594.1 - 0.027 13.1 5.7 0.041 12.5 5.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4746 PF15928.5 CDI85594.1 - 7.2 5.9 11.6 23 4.3 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Afi1 PF07792.12 CDI85594.1 - 7.7 7.0 23.7 13 6.2 0.2 3.5 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking VIT1 PF01988.19 CDI85595.1 - 0.11 12.3 3.4 0.15 11.9 3.4 1.2 1 0 0 1 1 1 0 VIT family TFIIA PF03153.13 CDI85595.1 - 0.36 10.8 28.0 0.37 10.7 28.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.15 CDI85595.1 - 1.3 8.6 15.7 1.3 8.6 15.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit SOBP PF15279.6 CDI85595.1 - 3.4 8.2 14.9 4.3 7.8 14.9 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein O-antigen_lig PF13425.6 CDI85595.1 - 5.9 5.6 6.5 7.5 5.2 6.5 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RskA PF10099.9 CDI85596.1 - 1.8e-06 28.3 9.0 1.8e-06 28.3 9.0 12.9 4 3 6 12 12 12 7 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI85596.1 - 0.0038 16.9 18.3 0.0038 16.9 18.3 10.5 8 1 2 10 10 10 8 Spt20 family TFIIF_alpha PF05793.12 CDI85597.1 - 0.33 9.5 46.7 0.5 8.9 46.7 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) O-antigen_lig PF13425.6 CDI85597.1 - 5.3 5.7 10.0 7.4 5.2 10.0 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Utp14 PF04615.13 CDI85597.1 - 5.7 5.4 55.5 7.1 5.1 55.5 1.0 1 0 0 1 1 1 0 Utp14 protein SR-25 PF10500.9 CDI85598.1 - 0.85 9.2 62.4 0.2 11.2 22.5 3.2 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein Surface_antigen PF11054.8 CDI85599.1 - 0.00025 20.8 0.1 0.00045 20.0 0.1 1.4 1 1 0 1 1 1 1 Sporozoite TA4 surface antigen PAT1 PF09770.9 CDI85599.1 - 0.002 16.5 35.5 0.0021 16.4 35.5 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Macoilin PF09726.9 CDI85599.1 - 0.058 12.0 19.6 0.075 11.6 19.6 1.2 1 0 0 1 1 1 0 Macoilin family RR_TM4-6 PF06459.12 CDI85599.1 - 0.061 13.2 17.7 0.078 12.8 17.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Exonuc_VII_L PF02601.15 CDI85599.1 - 0.099 12.2 14.6 0.11 12.0 14.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CDC45 PF02724.14 CDI85599.1 - 0.14 10.5 15.1 0.16 10.2 15.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Dapper PF15268.6 CDI85599.1 - 0.15 10.9 22.5 0.17 10.7 22.5 1.0 1 0 0 1 1 1 0 Dapper Endostatin PF06482.11 CDI85599.1 - 0.28 10.6 23.0 0.36 10.2 23.0 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin GREB1 PF15782.5 CDI85599.1 - 0.28 8.3 19.9 0.3 8.2 19.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 CDI85599.1 - 0.32 9.7 24.6 0.39 9.4 24.6 1.1 1 0 0 1 1 1 0 Presenilin Velvet PF11754.8 CDI85599.1 - 0.48 10.3 18.2 0.61 10.0 18.2 1.3 1 0 0 1 1 1 0 Velvet factor DUF4050 PF13259.6 CDI85599.1 - 0.49 10.7 15.8 0.76 10.1 15.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Caldesmon PF02029.15 CDI85599.1 - 0.5 9.1 17.0 0.55 8.9 17.0 1.1 1 0 0 1 1 1 0 Caldesmon DUF1387 PF07139.11 CDI85599.1 - 0.52 10.0 18.2 0.68 9.6 18.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Senescence_reg PF04520.13 CDI85599.1 - 0.77 10.6 17.6 1.1 10.1 17.6 1.2 1 0 0 1 1 1 0 Senescence regulator eIF-3_zeta PF05091.12 CDI85599.1 - 1.4 7.8 20.7 2 7.3 20.7 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NPR3 PF03666.13 CDI85599.1 - 1.7 7.3 20.6 2.1 7.0 20.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC12 PF03522.15 CDI85599.1 - 2 7.3 23.9 2.4 7.1 23.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4045 PF13254.6 CDI85599.1 - 2.1 7.9 17.1 2.4 7.7 17.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Hid1 PF12722.7 CDI85599.1 - 2.9 5.9 19.6 3.4 5.7 19.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Peptidase_S64 PF08192.11 CDI85599.1 - 3.4 6.0 19.0 4.3 5.7 19.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 AF-4 PF05110.13 CDI85599.1 - 3.5 5.6 31.9 4.2 5.3 31.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein MDM10 PF12519.8 CDI85599.1 - 3.5 6.4 17.6 4.3 6.1 17.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 PNISR PF15996.5 CDI85599.1 - 3.5 7.8 24.6 4.7 7.4 24.6 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Membralin PF09746.9 CDI85599.1 - 4.5 6.2 13.6 5.3 6.0 13.6 1.1 1 0 0 1 1 1 0 Tumour-associated protein CDK5_activator PF03261.15 CDI85599.1 - 5.4 6.5 22.3 6.6 6.2 22.3 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein AUX_IAA PF02309.16 CDI85599.1 - 5.4 6.8 12.9 7.2 6.4 12.9 1.2 1 0 0 1 1 1 0 AUX/IAA family FAM60A PF15396.6 CDI85599.1 - 6.1 6.8 20.0 8.5 6.3 20.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SID-1_RNA_chan PF13965.6 CDI85599.1 - 6.9 4.9 6.6 8 4.7 6.6 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RF-1 PF00472.20 CDI85600.1 - 1.1e-11 44.7 14.0 1.1e-11 44.7 14.0 2.3 2 0 0 2 2 2 1 RF-1 domain RskA PF10099.9 CDI85600.1 - 0.00064 20.1 28.8 0.00097 19.5 10.5 2.7 2 1 0 2 2 2 2 Anti-sigma-K factor rskA DUF572 PF04502.13 CDI85600.1 - 2 8.0 26.0 0.51 9.9 11.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) DUF3807 PF12720.7 CDI85600.1 - 7.9 6.7 30.3 3.4 7.9 9.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Presenilin PF01080.17 CDI85600.1 - 8.8 5.0 30.1 1.4 7.6 13.6 2.1 2 0 0 2 2 2 0 Presenilin V_ATPase_I PF01496.19 CDI85601.1 - 0.071 11.0 12.3 0.093 10.6 12.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TFIIA PF03153.13 CDI85601.1 - 0.14 12.1 41.2 0.17 11.9 41.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CitG PF01874.16 CDI85601.1 - 0.15 11.7 10.9 0.19 11.3 10.9 1.1 1 0 0 1 1 1 0 ATP:dephospho-CoA triphosphoribosyl transferase O-antigen_lig PF13425.6 CDI85601.1 - 0.28 9.9 3.1 0.3 9.8 3.1 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SID-1_RNA_chan PF13965.6 CDI85601.1 - 0.29 9.5 5.2 0.31 9.4 5.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 OATP PF03137.20 CDI85601.1 - 0.37 9.0 4.7 0.56 8.4 4.7 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Exonuc_VII_L PF02601.15 CDI85601.1 - 0.55 9.8 22.6 0.72 9.4 22.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PAT1 PF09770.9 CDI85601.1 - 0.88 7.8 27.3 0.92 7.7 27.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CLN3 PF02487.17 CDI85601.1 - 1.2 8.1 9.8 1.4 7.8 9.8 1.2 1 0 0 1 1 1 0 CLN3 protein AAA_23 PF13476.6 CDI85601.1 - 2.4 8.6 18.8 2.9 8.4 18.8 1.2 1 0 0 1 1 1 0 AAA domain CSG2 PF16965.5 CDI85601.1 - 2.5 7.0 10.2 2.9 6.7 10.2 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Adaptin_binding PF10199.9 CDI85603.1 - 0.0011 19.5 3.2 0.0011 19.5 3.2 2.2 1 1 1 2 2 2 1 Alpha and gamma adaptin binding protein p34 CNDH2_C PF16858.5 CDI85603.1 - 0.18 11.7 28.5 0.048 13.5 21.2 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term V_ATPase_I PF01496.19 CDI85603.1 - 0.32 8.9 29.1 0.012 13.6 20.8 1.9 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family MMR1 PF08505.10 CDI85603.1 - 0.87 9.8 46.0 3.8 7.7 35.9 2.3 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein DUF2052 PF09747.9 CDI85603.1 - 3.6 7.7 32.6 11 6.1 28.2 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) AAA_11 PF13086.6 CDI85603.1 - 4.9 6.9 31.2 20 4.9 28.1 2.2 2 0 0 2 2 2 0 AAA domain DUF4175 PF13779.6 CDI85603.1 - 8.9 4.1 79.5 2.4 5.9 65.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) Lin-8 PF03353.15 CDI85603.1 - 8.9 5.8 51.0 6.8 6.2 39.0 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist TFIIA PF03153.13 CDI85604.1 - 0.16 11.9 66.7 0.22 11.5 66.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TCP PF03634.13 CDI85604.1 - 0.96 10.0 24.7 0.23 12.0 16.3 2.2 2 0 0 2 2 2 0 TCP family transcription factor FAM60A PF15396.6 CDI85604.1 - 10 6.1 24.0 6.7 6.7 19.2 2.0 2 0 0 2 2 2 0 Protein Family FAM60A RskA PF10099.9 CDI85605.1 - 0.00022 21.6 2.5 0.00022 21.6 2.5 3.1 1 1 2 3 3 1 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI85605.1 - 0.0016 18.5 47.9 0.0025 17.9 47.9 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SOBP PF15279.6 CDI85605.1 - 0.21 12.2 24.0 0.27 11.8 24.0 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein PE_PPE_C PF12484.8 CDI85605.1 - 0.76 10.7 27.5 0.85 10.6 3.5 2.4 2 0 0 2 2 2 0 Polymorphic PE/PPE proteins C terminal PAT1 PF09770.9 CDI85605.1 - 0.85 7.8 38.6 1 7.6 38.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SAPS PF04499.15 CDI85605.1 - 2.1 7.0 18.0 2.6 6.7 18.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Hid1 PF12722.7 CDI85605.1 - 3.2 5.8 25.3 3.7 5.6 25.3 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SLC12 PF03522.15 CDI85605.1 - 3.2 6.7 22.7 4.8 6.1 22.7 1.3 1 0 0 1 1 1 0 Solute carrier family 12 DUF4776 PF16003.5 CDI85605.1 - 3.3 6.6 24.8 4.3 6.2 24.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) LMBR1 PF04791.16 CDI85605.1 - 3.6 6.4 10.2 4.3 6.1 10.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Paramyxo_ncap PF00973.19 CDI85605.1 - 9.1 5.1 16.6 13 4.5 16.6 1.4 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein CDK2AP PF09806.9 CDI85606.1 - 0.0033 17.5 25.6 0.0036 17.4 25.6 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase 2-associated protein JUPITER PF17054.5 CDI85606.1 - 0.0083 15.6 2.5 0.0093 15.5 2.5 1.2 1 0 0 1 1 1 1 Microtubule-Associated protein Jupiter SR-25 PF10500.9 CDI85606.1 - 0.056 13.0 18.1 0.064 12.9 18.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MPM1 PF17234.2 CDI85606.1 - 0.36 11.1 14.9 0.46 10.7 14.9 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 IMUP PF15761.5 CDI85606.1 - 0.7 10.6 11.3 1.1 10.0 11.2 1.5 1 1 0 1 1 1 0 Immortalisation up-regulated protein PNISR PF15996.5 CDI85606.1 - 0.82 9.9 23.3 0.87 9.8 23.3 1.0 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF4692 PF15763.5 CDI85606.1 - 1.6 9.2 10.7 1.9 9.0 10.7 1.2 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) DUF4820 PF16091.5 CDI85606.1 - 2.8 7.2 15.9 3.3 7.0 15.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TFIIA PF03153.13 CDI85606.1 - 2.9 7.8 34.1 3.4 7.6 34.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CDI85606.1 - 4.5 6.7 18.8 4.9 6.6 18.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Maf1 PF09174.10 CDI85606.1 - 4.9 7.3 10.0 6.1 7.0 10.0 1.3 1 0 0 1 1 1 0 Maf1 regulator MAT1 PF06391.13 CDI85606.1 - 5.4 6.8 21.3 6.3 6.6 21.3 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 MMU163 PF17119.5 CDI85606.1 - 5.9 6.0 11.1 7.2 5.7 11.1 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Apt1 PF10351.9 CDI85606.1 - 8.1 5.2 16.3 8.4 5.1 16.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain stn_TNFRSF12A PF12191.8 CDI85606.1 - 8.4 6.6 6.9 1.5 9.0 2.7 1.7 1 1 1 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Sec62 PF03839.16 CDI85606.1 - 9.6 5.6 14.2 11 5.5 14.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Gti1_Pac2 PF09729.9 CDI85606.1 - 9.6 6.3 16.4 12 6.0 16.4 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF1635 PF07795.11 CDI85606.1 - 9.6 6.0 20.4 12 5.7 20.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Dapper PF15268.6 CDI85607.1 - 3.5 6.4 44.5 4 6.2 44.5 1.2 1 0 0 1 1 1 0 Dapper Asp-B-Hydro_N PF05279.11 CDI85607.1 - 6.4 6.8 20.7 8.1 6.4 20.7 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Presenilin PF01080.17 CDI85609.1 - 5.3 5.7 21.6 5.8 5.6 21.6 1.0 1 0 0 1 1 1 0 Presenilin Peptidase_M56 PF05569.11 CDI85610.1 - 0.1 11.8 2.1 0.14 11.3 2.1 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 N6_N4_Mtase PF01555.18 CDI85610.1 - 0.17 11.6 2.1 0.66 9.6 2.1 1.9 1 1 0 1 1 1 0 DNA methylase Trypan_PARP PF05887.11 CDI85610.1 - 0.34 10.9 3.6 0.49 10.4 3.6 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF572 PF04502.13 CDI85610.1 - 1.2 8.7 32.2 1.6 8.3 32.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) SR-25 PF10500.9 CDI85610.1 - 1.4 8.5 44.0 0.14 11.8 8.0 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein GREB1 PF15782.5 CDI85610.1 - 1.9 5.5 30.7 2.2 5.3 30.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NLRC4_HD PF17889.1 CDI85610.1 - 3.2 8.1 12.5 0.18 12.2 6.0 2.0 1 1 1 2 2 2 0 NLRC4 helical domain Bul1_C PF04426.12 CDI85611.1 - 2.7 7.3 15.1 0.16 11.4 2.2 2.2 2 0 0 2 2 2 0 Bul1 C terminus RskA PF10099.9 CDI85612.1 - 0.012 15.9 0.4 0.012 15.9 0.4 2.4 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI85612.1 - 0.26 10.0 1.4 0.3 9.8 1.4 1.1 1 0 0 1 1 1 0 Presenilin DUF3408 PF11888.8 CDI85612.1 - 0.37 10.9 5.4 0.59 10.3 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) SelP_N PF04592.14 CDI85612.1 - 1.7 8.0 11.7 2.6 7.4 11.7 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Pex14_N PF04695.13 CDI85612.1 - 3.1 8.4 13.6 0.57 10.8 8.8 2.1 1 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Zip PF02535.22 CDI85612.1 - 4 6.5 4.7 6.4 5.9 4.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter API5 PF05918.11 CDI85612.1 - 9.2 4.9 9.3 13 4.5 9.3 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) LETM1 PF07766.13 CDI85613.1 - 1.2e-51 175.7 2.0 1.2e-51 175.7 2.0 2.7 3 1 0 3 3 3 1 LETM1-like protein Kinase-like PF14531.6 CDI85616.1 - 2e-08 33.9 0.0 2.6e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.25 CDI85616.1 - 3.7e-08 33.1 0.0 5.7e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI85616.1 - 1.6e-05 24.4 0.0 2.5e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SR-25 PF10500.9 CDI85619.1 - 1.1 8.8 27.3 4.7 6.8 0.5 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI85619.1 - 3.7 7.8 61.9 1.8e+03 -1.0 46.1 2.7 1 1 1 2 2 2 0 Anti-sigma-K factor rskA ETRAMP PF09716.10 CDI85620.1 - 0.092 12.8 0.6 0.33 11.1 0.6 1.9 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF2973 PF11189.8 CDI85620.1 - 1.6 8.8 8.1 11 6.2 0.0 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2973) RskA PF10099.9 CDI85620.1 - 2.2 8.6 20.6 4.1 7.7 0.0 3.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI85621.1 - 0.0027 18.0 77.4 0.004 17.5 7.1 4.5 3 2 1 4 4 4 3 Anti-sigma-K factor rskA Macoilin PF09726.9 CDI85621.1 - 0.5 8.8 8.6 0.099 11.2 4.3 1.8 2 0 0 2 2 2 0 Macoilin family AF-4 PF05110.13 CDI85621.1 - 3.9 5.5 17.6 0.19 9.8 11.3 1.9 2 0 0 2 2 2 0 AF-4 proto-oncoprotein RskA PF10099.9 CDI85622.1 - 3.6 7.9 30.0 0.32 11.3 9.3 2.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Utp14 PF04615.13 CDI85622.1 - 3.8 6.0 33.1 4.7 5.7 33.1 1.0 1 0 0 1 1 1 0 Utp14 protein Terminase_2 PF03592.16 CDI85622.1 - 6.1 7.3 8.4 10 6.6 8.2 1.4 1 1 0 1 1 1 0 Terminase small subunit V_ATPase_I PF01496.19 CDI85624.1 - 0.043 11.8 29.3 0.044 11.7 29.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TRAP_alpha PF03896.16 CDI85624.1 - 0.11 11.7 13.7 0.13 11.4 13.7 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CobT PF06213.12 CDI85624.1 - 0.18 11.2 38.6 0.19 11.1 38.6 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF1180 PF06679.12 CDI85624.1 - 0.34 11.3 10.9 0.38 11.1 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DREPP PF05558.12 CDI85624.1 - 0.91 9.4 5.2 1.1 9.1 5.2 1.0 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide MMM1 PF10296.9 CDI85624.1 - 0.95 8.5 15.9 1.1 8.3 15.9 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 CLN3 PF02487.17 CDI85624.1 - 0.95 8.4 23.3 1 8.3 23.3 1.0 1 0 0 1 1 1 0 CLN3 protein DUF2828 PF11443.8 CDI85624.1 - 0.96 7.4 28.9 1.1 7.2 28.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Connexin PF00029.19 CDI85624.1 - 1 9.1 21.7 1.4 8.6 21.7 1.3 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 CDI85624.1 - 1.3 7.8 34.1 1.4 7.7 34.1 1.0 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 CDI85624.1 - 1.3 7.4 16.7 1.3 7.4 16.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Scs3p PF10261.9 CDI85624.1 - 1.4 8.3 12.9 1.8 8.0 12.9 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM SpoIIP PF07454.11 CDI85624.1 - 1.6 8.2 28.4 2.1 7.7 28.4 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Peptidase_S49_N PF08496.10 CDI85624.1 - 2.2 8.3 28.4 2.5 8.2 28.4 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RR_TM4-6 PF06459.12 CDI85624.1 - 2.7 7.8 30.4 2.9 7.6 30.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI85624.1 - 3.1 6.7 30.1 3.3 6.6 30.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Folate_carrier PF01770.18 CDI85624.1 - 4.2 6.0 16.5 5.7 5.6 16.5 1.3 1 0 0 1 1 1 0 Reduced folate carrier Serinc PF03348.15 CDI85624.1 - 4.5 6.1 18.6 5 5.9 18.6 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) FAM176 PF14851.6 CDI85624.1 - 4.6 6.9 21.6 7.8 6.2 21.6 1.4 1 1 0 1 1 1 0 FAM176 family CSG2 PF16965.5 CDI85624.1 - 5.1 5.9 17.6 5.4 5.8 17.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator SARAF PF06682.12 CDI85624.1 - 5.4 6.6 25.6 5.8 6.5 25.6 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Ctr PF04145.15 CDI85624.1 - 5.6 7.6 18.8 7.1 7.2 18.8 1.2 1 0 0 1 1 1 0 Ctr copper transporter family DUF913 PF06025.12 CDI85624.1 - 5.6 5.8 19.2 6.1 5.7 19.2 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) eIF-3_zeta PF05091.12 CDI85624.1 - 5.7 5.8 38.0 6.2 5.7 38.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rtf2 PF04641.12 CDI85624.1 - 5.7 6.2 26.9 6.7 6.0 26.9 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger CCDC53 PF10152.9 CDI85624.1 - 5.8 7.3 29.0 7.6 6.9 29.0 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF4446 PF14584.6 CDI85624.1 - 6.9 6.6 17.9 7.7 6.5 17.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) NARP1 PF12569.8 CDI85624.1 - 7.1 5.4 27.9 7.6 5.3 27.9 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CBP_BcsG PF11658.8 CDI85624.1 - 8.9 4.6 25.4 9.8 4.4 25.4 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Velvet PF11754.8 CDI85624.1 - 8.9 6.2 27.6 11 5.9 27.6 1.0 1 0 0 1 1 1 0 Velvet factor Gti1_Pac2 PF09729.9 CDI85624.1 - 9.7 6.2 25.6 11 6.1 25.6 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family TFIIA PF03153.13 CDI85625.1 - 0.21 11.6 65.0 0.28 11.1 65.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AP2 PF00847.20 CDI85627.1 - 1.2e-09 38.2 0.6 1.2e-09 38.2 0.6 2.7 2 0 0 2 2 2 1 AP2 domain PNISR PF15996.5 CDI85628.1 - 3.1e-05 24.3 0.4 3.1e-05 24.3 0.4 4.3 3 1 0 3 3 3 1 Arginine/serine-rich protein PNISR SUIM_assoc PF16619.5 CDI85628.1 - 0.0064 16.5 3.0 0.0064 16.5 3.0 4.8 3 1 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 Lin-8 PF03353.15 CDI85628.1 - 0.0066 16.1 8.8 0.0066 16.1 8.8 4.3 4 1 0 4 4 4 1 Ras-mediated vulval-induction antagonist FHIPEP PF00771.20 CDI85628.1 - 1.5 7.2 5.7 3.4 6.0 5.7 1.6 1 0 0 1 1 1 0 FHIPEP family Peptidase_S49_N PF08496.10 CDI85628.1 - 3.8 7.6 9.5 12 5.9 3.9 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal MtN3_slv PF03083.16 CDI85629.1 - 7e-13 48.4 0.6 1.1e-12 47.8 0.6 1.3 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange Spt20 PF12090.8 CDI85629.1 - 0.0032 17.1 15.6 0.0032 17.1 15.6 4.6 3 1 1 4 4 4 2 Spt20 family SARAF PF06682.12 CDI85629.1 - 0.014 15.1 1.1 0.014 15.1 1.1 3.4 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis AAA_11 PF13086.6 CDI85629.1 - 0.21 11.4 42.4 0.15 11.8 21.6 3.5 3 0 0 3 3 3 0 AAA domain DUF4235 PF14019.6 CDI85630.1 - 0.095 12.8 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4235) AMPK1_CBM PF16561.5 CDI85631.1 - 2.8e-18 65.9 0.0 5e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase EPL1 PF10513.9 CDI85631.1 - 0.0013 19.1 0.3 0.0013 19.1 0.3 1.7 2 0 0 2 2 2 1 Enhancer of polycomb-like DUF755 PF05501.11 CDI85631.1 - 0.0033 17.7 14.5 0.0033 17.7 14.5 2.4 1 1 1 2 2 1 1 Domain of unknown function (DUF755) Macoilin PF09726.9 CDI85631.1 - 0.0036 16.0 16.0 0.0042 15.7 16.0 1.0 1 0 0 1 1 1 1 Macoilin family Apt1 PF10351.9 CDI85631.1 - 0.09 11.6 15.1 0.1 11.4 15.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 CDI85631.1 - 0.096 12.6 17.3 0.12 12.3 17.3 1.1 1 0 0 1 1 1 0 SPX domain Presenilin PF01080.17 CDI85631.1 - 0.16 10.7 6.0 0.18 10.5 6.0 1.2 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 CDI85631.1 - 0.33 10.5 11.5 0.49 10.0 11.5 1.2 1 0 0 1 1 1 0 Spt20 family GREB1 PF15782.5 CDI85631.1 - 0.74 6.9 12.4 0.82 6.7 12.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Sec3_C PF09763.9 CDI85631.1 - 1.2 7.4 7.0 1.3 7.3 7.0 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Hid1 PF12722.7 CDI85631.1 - 1.5 6.8 8.0 1.8 6.6 8.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HSD3 PF15244.6 CDI85631.1 - 1.5 8.2 19.3 1.9 7.9 19.3 1.0 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 Menin PF05053.13 CDI85631.1 - 3.5 5.9 8.2 4.4 5.5 8.2 1.1 1 0 0 1 1 1 0 Menin Smg8_Smg9 PF10220.9 CDI85631.1 - 5.3 5.2 8.8 5.9 5.1 8.8 1.1 1 0 0 1 1 1 0 Smg8_Smg9 CCDC106 PF15794.5 CDI85631.1 - 7.9 6.1 17.4 15 5.3 17.4 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 RR_TM4-6 PF06459.12 CDI85632.1 - 0.0046 16.8 9.7 0.0057 16.5 9.7 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 MCU PF04678.13 CDI85632.1 - 0.0089 16.1 6.6 0.0098 16.0 6.6 1.1 1 0 0 1 1 1 1 Mitochondrial calcium uniporter HAUS6_N PF14661.6 CDI85632.1 - 0.014 14.9 15.5 0.016 14.8 15.5 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus TFIIA PF03153.13 CDI85632.1 - 0.017 15.1 40.0 0.02 14.9 40.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI85632.1 - 0.031 14.4 7.2 0.031 14.3 7.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LMBR1 PF04791.16 CDI85632.1 - 0.034 13.1 2.8 0.03 13.3 2.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Activator_LAG-3 PF11498.8 CDI85632.1 - 0.052 12.5 57.3 0.063 12.3 57.3 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 EOS1 PF12326.8 CDI85632.1 - 0.053 13.4 1.3 0.052 13.5 1.3 1.2 1 0 0 1 1 1 0 N-glycosylation protein RskA PF10099.9 CDI85632.1 - 0.058 13.7 18.2 0.13 12.5 18.2 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Suf PF05843.14 CDI85632.1 - 0.063 13.3 15.0 0.076 13.0 15.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Coilin_N PF15862.5 CDI85632.1 - 0.1 12.4 11.5 0.13 12.0 11.5 1.3 1 0 0 1 1 1 0 Coilin N-terminus PAT1 PF09770.9 CDI85632.1 - 0.11 10.8 25.3 0.11 10.7 25.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Exonuc_VII_L PF02601.15 CDI85632.1 - 0.11 12.1 14.4 0.12 11.9 14.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit EIF4E-T PF10477.9 CDI85632.1 - 0.11 11.3 22.3 0.11 11.3 22.3 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E FAM60A PF15396.6 CDI85632.1 - 0.12 12.3 8.5 0.16 12.0 8.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A IATP PF04568.12 CDI85632.1 - 0.21 12.1 0.1 0.21 12.1 0.1 2.4 1 1 1 2 2 1 0 Mitochondrial ATPase inhibitor, IATP MMR1 PF08505.10 CDI85632.1 - 0.23 11.7 14.8 0.28 11.4 14.8 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF4569 PF15133.6 CDI85632.1 - 0.35 10.6 19.0 0.44 10.2 19.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Peroxin-13_N PF04088.13 CDI85632.1 - 0.39 11.0 7.3 0.51 10.6 7.3 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region ABC2_membrane_3 PF12698.7 CDI85632.1 - 0.44 9.6 3.1 0.46 9.5 3.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein eIF-3_zeta PF05091.12 CDI85632.1 - 0.45 9.4 18.8 0.51 9.2 18.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SprA-related PF12118.8 CDI85632.1 - 0.47 9.5 27.9 0.59 9.2 27.9 1.1 1 0 0 1 1 1 0 SprA-related family Pkinase_fungal PF17667.1 CDI85632.1 - 0.49 9.1 9.6 0.61 8.8 9.6 1.1 1 0 0 1 1 1 0 Fungal protein kinase Serinc PF03348.15 CDI85632.1 - 0.56 9.1 5.3 0.6 9.0 5.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DDHD PF02862.17 CDI85632.1 - 0.72 10.0 11.5 0.83 9.8 11.5 1.1 1 0 0 1 1 1 0 DDHD domain Hid1 PF12722.7 CDI85632.1 - 0.73 7.9 13.0 0.83 7.7 13.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM91_C PF14648.6 CDI85632.1 - 0.78 8.5 10.3 0.99 8.2 10.3 1.1 1 0 0 1 1 1 0 FAM91 C-terminus FAM222A PF15258.6 CDI85632.1 - 1.1 8.3 27.1 1.1 8.2 27.1 1.1 1 0 0 1 1 1 0 Protein family of FAM222A EIIBC-GUT_N PF03612.14 CDI85632.1 - 1.4 8.6 11.4 2.1 8.1 11.4 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Cellulose_synt PF03552.14 CDI85632.1 - 1.9 6.9 9.9 2.4 6.6 9.9 1.1 1 0 0 1 1 1 0 Cellulose synthase Connexin PF00029.19 CDI85632.1 - 2.5 7.8 11.8 3 7.5 11.8 1.1 1 0 0 1 1 1 0 Connexin Bul1_N PF04425.12 CDI85632.1 - 2.9 6.5 14.6 3.6 6.2 14.6 1.0 1 0 0 1 1 1 0 Bul1 N terminus SpoIIP PF07454.11 CDI85632.1 - 4.2 6.8 16.1 5.4 6.4 16.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FapA PF03961.13 CDI85632.1 - 4.4 5.8 10.2 5 5.6 10.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Gti1_Pac2 PF09729.9 CDI85632.1 - 4.5 7.3 10.6 6 6.9 10.6 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Rrn6 PF10214.9 CDI85632.1 - 5.5 5.4 21.7 6.9 5.0 21.7 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CLN3 PF02487.17 CDI85632.1 - 5.7 5.9 12.0 6.7 5.6 12.0 1.1 1 0 0 1 1 1 0 CLN3 protein FdhD-NarQ PF02634.15 CDI85632.1 - 5.7 6.5 8.8 6.7 6.3 8.8 1.1 1 0 0 1 1 1 0 FdhD/NarQ family Presenilin PF01080.17 CDI85632.1 - 5.8 5.6 19.9 7.1 5.3 19.9 1.1 1 0 0 1 1 1 0 Presenilin DOR PF14839.6 CDI85632.1 - 6.3 6.7 18.7 7.7 6.4 18.7 1.2 1 0 0 1 1 1 0 DOR family EPL1 PF10513.9 CDI85632.1 - 7.2 7.0 15.8 12 6.3 15.8 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like FAM70 PF14967.6 CDI85632.1 - 7.6 5.9 10.0 8.4 5.7 10.0 1.1 1 0 0 1 1 1 0 FAM70 protein Band_3_cyto PF07565.13 CDI85632.1 - 7.8 6.2 18.3 10 5.8 18.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SLC12 PF03522.15 CDI85632.1 - 7.9 5.4 17.6 9.8 5.1 17.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SART-1 PF03343.13 CDI85633.1 - 4e-52 177.7 107.3 1.5e-25 89.9 28.5 5.9 3 2 1 4 4 4 3 SART-1 family Ecl1 PF12855.7 CDI85633.1 - 1.9 9.6 67.5 1.1 10.4 24.8 4.6 4 0 0 4 4 4 0 ECL1/2/3 zinc binding proteins SID-1_RNA_chan PF13965.6 CDI85633.1 - 4.8 5.5 17.6 0.16 10.4 4.4 2.6 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF3112 PF11309.8 CDI85633.1 - 5.1 6.5 5.9 14 5.0 5.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) DUF4207 PF13904.6 CDI85633.1 - 6.8 6.3 0.0 6.8 6.3 0.0 7.0 4 2 3 7 7 7 0 Domain of unknown function (DUF4207) DUF572 PF04502.13 CDI85634.1 - 0.097 12.3 16.9 0.11 12.1 16.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) GHMP_kinases_N PF00288.26 CDI85634.1 - 0.16 12.2 16.4 4.7 7.5 0.0 3.5 3 0 0 3 3 3 0 GHMP kinases N terminal domain PAT1 PF09770.9 CDI85634.1 - 1.7 6.8 35.0 1.9 6.7 35.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RFamide_26RFa PF11109.8 CDI85634.1 - 2.5 8.6 20.7 0.074 13.6 10.4 2.3 1 1 1 2 2 2 0 Orexigenic neuropeptide Qrfp/P518 SLC12 PF03522.15 CDI85634.1 - 8.5 5.3 22.6 12 4.8 22.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 RskA PF10099.9 CDI85635.1 - 0.012 15.9 2.7 0.012 15.9 2.7 6.1 1 1 4 5 5 5 0 Anti-sigma-K factor rskA Caldesmon PF02029.15 CDI85636.1 - 4.1e-06 25.8 26.1 4.4e-06 25.7 26.1 1.1 1 0 0 1 1 1 1 Caldesmon SLC12 PF03522.15 CDI85636.1 - 0.19 10.7 36.1 0.32 10.0 36.1 1.3 1 0 0 1 1 1 0 Solute carrier family 12 CDK5_activator PF03261.15 CDI85636.1 - 0.22 11.0 30.9 0.35 10.4 30.9 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein CDC45 PF02724.14 CDI85636.1 - 0.32 9.2 35.7 0.45 8.8 35.7 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF572 PF04502.13 CDI85636.1 - 1 8.9 32.9 0.19 11.3 28.3 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF572) PNISR PF15996.5 CDI85636.1 - 2.1 8.6 49.6 0.48 10.7 44.5 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Vac7 PF12751.7 CDI85636.1 - 3.5 7.0 23.0 6.5 6.1 23.0 1.5 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 Raftlin PF15250.6 CDI85636.1 - 6.6 5.4 29.2 0.6 8.8 25.0 1.5 2 0 0 2 2 2 0 Raftlin BAF1_ABF1 PF04684.13 CDI85636.1 - 8 5.4 40.3 6.8 5.6 31.9 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor X PF00739.19 CDI85636.1 - 8 6.6 8.4 11 6.2 0.0 2.3 2 0 0 2 2 2 0 Trans-activation protein X SR-25 PF10500.9 CDI85637.1 - 0.022 14.4 31.2 0.59 9.7 18.3 3.4 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein SPX PF03105.19 CDI85637.1 - 0.52 10.2 18.3 0.95 9.3 18.3 1.4 1 0 0 1 1 1 0 SPX domain RSRP PF17069.5 CDI85637.1 - 0.8 9.2 22.7 1.4 8.5 22.7 1.4 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 DUF4148 PF13663.6 CDI85637.1 - 1.2 9.4 37.6 5.7 7.2 0.6 5.7 5 0 0 5 5 5 0 Domain of unknown function (DUF4148) SR-25 PF10500.9 CDI85640.1 - 0.001 18.7 9.0 0.001 18.7 9.0 6.9 6 2 0 6 6 6 1 Nuclear RNA-splicing-associated protein BAF1_ABF1 PF04684.13 CDI85641.1 - 1.7 7.6 15.3 1.9 7.5 15.3 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor R_equi_Vir PF05526.11 CDI85641.1 - 1.8 8.4 7.9 2.5 7.9 7.9 1.3 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF1980 PF09323.10 CDI85641.1 - 2.4 8.0 7.7 3 7.7 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) TFIIA PF03153.13 CDI85641.1 - 3.7 7.4 38.2 4.3 7.2 38.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3450 PF11932.8 CDI85641.1 - 3.8 6.7 27.7 4.4 6.5 27.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) RR_TM4-6 PF06459.12 CDI85641.1 - 5.5 6.7 16.0 6.3 6.5 16.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MAJIN PF15077.6 CDI85641.1 - 5.8 6.6 8.9 6.6 6.4 8.9 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein Band_3_cyto PF07565.13 CDI85641.1 - 6.7 6.4 11.9 7.7 6.2 11.9 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Connexin PF00029.19 CDI85641.1 - 7 6.3 8.6 8 6.1 8.6 1.2 1 0 0 1 1 1 0 Connexin SpoIIP PF07454.11 CDI85641.1 - 7.3 6.0 13.1 8.7 5.7 13.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Pex14_N PF04695.13 CDI85641.1 - 7.9 7.1 23.0 12 6.5 23.0 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region WD40 PF00400.32 CDI85642.1 - 0.00017 22.3 0.1 0.08 13.9 0.0 3.1 2 0 0 2 2 2 2 WD domain, G-beta repeat P2X_receptor PF00864.19 CDI85642.1 - 1.5 7.8 3.6 0.48 9.4 0.7 1.6 2 0 0 2 2 2 0 ATP P2X receptor SLC12 PF03522.15 CDI85644.1 - 0.93 8.4 40.7 0.49 9.3 12.3 2.2 2 0 0 2 2 2 0 Solute carrier family 12 DUF3328 PF11807.8 CDI85645.1 - 0.0002 21.2 0.1 0.0002 21.2 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3328) Cwf_Cwc_15 PF04889.12 CDI85645.1 - 0.00033 20.5 16.5 0.00033 20.5 16.5 3.1 3 0 0 3 3 3 1 Cwf15/Cwc15 cell cycle control protein SurA_N_3 PF13624.6 CDI85645.1 - 0.00062 19.6 7.2 0.00062 19.6 7.2 3.4 2 1 1 3 3 1 1 SurA N-terminal domain DUF2207 PF09972.9 CDI85645.1 - 0.002 17.0 4.9 0.79 8.4 3.3 2.2 2 0 0 2 2 2 2 Predicted membrane protein (DUF2207) DUF4407 PF14362.6 CDI85645.1 - 0.0028 17.1 4.1 0.0028 17.1 4.1 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4407) Claudin_2 PF13903.6 CDI85645.1 - 0.0084 15.9 0.8 0.039 13.7 0.2 2.4 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Ribosomal_60s PF00428.19 CDI85645.1 - 0.0098 16.5 5.5 0.0098 16.5 5.5 4.7 5 1 0 5 5 4 1 60s Acidic ribosomal protein CD20 PF04103.15 CDI85645.1 - 0.034 14.2 0.7 0.034 14.2 0.7 3.2 3 1 0 3 3 3 0 CD20-like family Renin_r PF07850.14 CDI85645.1 - 0.32 11.6 0.0 0.32 11.6 0.0 4.2 3 1 1 4 4 4 0 Renin receptor-like protein PBP1_TM PF14812.6 CDI85645.1 - 5.4 7.5 32.6 0.09 13.2 0.7 3.1 2 1 1 3 3 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Utp14 PF04615.13 CDI85645.1 - 8.8 4.8 54.9 0.062 11.9 41.5 2.1 1 1 1 2 2 2 0 Utp14 protein DUF1645 PF07816.11 CDI85646.1 - 0.0033 18.0 8.6 0.0033 18.0 8.6 3.1 2 1 0 2 2 2 1 Protein of unknown function (DUF1645) RskA PF10099.9 CDI85646.1 - 0.12 12.7 20.0 0.4 11.0 16.0 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI85646.1 - 1.9 7.1 11.9 0.27 10.0 1.6 2.1 2 0 0 2 2 2 0 Presenilin Striatin PF08232.12 CDI85646.1 - 3.5 8.2 8.3 2.4 8.7 1.4 2.1 2 0 0 2 2 2 0 Striatin family Lin-8 PF03353.15 CDI85646.1 - 3.8 7.0 16.6 0.7 9.4 4.6 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist PNISR PF15996.5 CDI85646.1 - 8.6 6.6 8.9 3 8.1 2.5 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Spore_coat_CotO PF14153.6 CDI85647.1 - 0.64 9.9 23.2 0.73 9.7 23.2 1.1 1 0 0 1 1 1 0 Spore coat protein CotO PA26 PF04636.13 CDI85647.1 - 1.8 7.4 12.4 2.1 7.2 12.4 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Roughex PF06020.11 CDI85647.1 - 3.4 6.7 13.4 3.8 6.5 13.4 1.1 1 0 0 1 1 1 0 Drosophila roughex protein TFIIA PF03153.13 CDI85647.1 - 4.3 7.2 30.8 4.7 7.1 30.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Otopetrin PF03189.13 CDI85649.1 - 6.5e-06 25.2 0.0 0.0017 17.3 0.0 3.4 2 1 0 2 2 2 1 Otopetrin SPX PF03105.19 CDI85649.1 - 2.8e-05 24.2 1.8 2.8e-05 24.2 1.8 3.9 2 2 0 2 2 2 1 SPX domain TFIIA PF03153.13 CDI85649.1 - 0.00094 19.3 24.7 0.00094 19.3 24.7 4.1 3 1 1 4 4 4 1 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI85649.1 - 0.054 13.6 0.1 0.054 13.6 0.1 4.3 3 1 1 4 4 4 0 Neurotransmitter-gated ion-channel transmembrane region Haem_degrading PF03928.14 CDI85650.1 - 0.033 14.2 0.9 0.038 14.0 0.9 1.1 1 0 0 1 1 1 0 Haem-degrading RRM_1 PF00076.22 CDI85651.1 - 1.1e-14 54.0 0.0 1.9e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ctr PF04145.15 CDI85653.1 - 0.00088 19.9 0.6 0.0014 19.2 0.6 1.3 1 0 0 1 1 1 1 Ctr copper transporter family GLTP PF08718.11 CDI85654.1 - 1.2e-23 84.0 0.0 1.5e-23 83.7 0.0 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) UQ_con PF00179.26 CDI85656.1 - 1.3e-45 154.5 0.0 1.5e-45 154.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDI85656.1 - 0.077 12.7 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 CDI85656.1 - 0.36 11.1 2.0 0.89 9.9 2.0 1.6 1 1 0 1 1 1 0 RWD domain SNF2_N PF00176.23 CDI85657.1 - 3.1e-46 157.7 0.3 9.6e-24 83.7 0.0 3.8 3 1 0 3 3 3 3 SNF2 family N-terminal domain Helicase_C PF00271.31 CDI85657.1 - 1.9e-08 34.6 0.0 1.3e-07 32.0 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain zf-PARP PF00645.18 CDI85657.1 - 0.00023 22.0 0.1 0.00023 22.0 0.1 2.5 2 0 0 2 2 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region DEAD PF00270.29 CDI85657.1 - 0.0013 18.6 0.0 0.13 12.0 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase zf-rbx1 PF12678.7 CDI85657.1 - 0.0021 18.3 3.2 0.031 14.5 0.2 3.8 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CDI85657.1 - 0.014 15.3 0.1 0.014 15.3 0.1 3.5 4 0 0 4 4 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDI85657.1 - 0.02 15.2 0.2 0.02 15.2 0.2 3.5 3 0 0 3 3 2 0 Ring finger domain FANCL_C PF11793.8 CDI85657.1 - 0.04 14.1 0.3 0.35 11.1 0.0 2.7 2 0 0 2 2 2 0 FANCL C-terminal domain PyrI_C PF02748.15 CDI85657.1 - 0.1 12.5 0.2 0.26 11.2 0.2 1.7 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-RING_11 PF17123.5 CDI85657.1 - 0.25 11.1 3.9 0.49 10.2 0.1 2.8 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDI85657.1 - 0.34 10.8 0.0 0.34 10.8 0.0 3.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDI85657.1 - 2.6 8.1 7.3 0.88 9.7 0.1 3.3 2 1 1 3 3 3 0 RING-type zinc-finger Reticulon PF02453.17 CDI85658.1 - 2.9e-09 37.1 0.9 5.2e-09 36.3 0.7 1.4 1 1 1 2 2 2 1 Reticulon UQ_con PF00179.26 CDI85659.1 - 1.6e-13 50.5 0.0 2.3e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CDI85659.1 - 0.081 13.2 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain Vps36-NZF-N PF16988.5 CDI85659.1 - 0.1 12.0 0.1 0.25 10.8 0.1 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Cadherin PF00028.17 CDI85659.1 - 0.24 11.9 0.0 0.68 10.4 0.0 1.7 1 0 0 1 1 1 0 Cadherin domain CBM_48 PF02922.18 CDI85660.1 - 9.6e-22 77.1 0.0 2.3e-20 72.7 0.0 3.1 4 0 0 4 4 4 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C PF02806.18 CDI85660.1 - 3.3e-19 69.2 0.0 1.9e-18 66.7 0.0 2.2 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 CDI85660.1 - 2.7e-14 53.5 0.2 7.4e-06 25.7 0.0 3.0 1 1 1 2 2 2 2 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 CDI85660.1 - 0.0077 16.3 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain PDEase_I PF00233.19 CDI85661.1 - 4.1e-60 203.5 6.5 1.9e-30 106.3 0.0 2.3 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase GAF_3 PF13492.6 CDI85661.1 - 0.019 15.3 0.1 0.068 13.5 0.0 2.0 2 0 0 2 2 2 0 GAF domain RCC1_2 PF13540.6 CDI85662.1 - 5.2e-07 29.3 15.8 0.079 12.8 1.3 4.8 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 CDI85662.1 - 0.00043 20.9 21.1 0.0019 18.7 0.0 6.8 6 2 0 6 6 6 2 Regulator of chromosome condensation (RCC1) repeat AAA_18 PF13238.6 CDI85663.1 - 0.00044 20.8 0.0 0.0007 20.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 CDI85663.1 - 0.0037 16.3 0.0 0.0061 15.6 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB KTI12 PF08433.10 CDI85663.1 - 0.023 14.1 0.0 0.034 13.6 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_33 PF13671.6 CDI85663.1 - 0.039 14.1 0.0 0.067 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CDI85663.1 - 0.098 11.9 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.23 CDI85663.1 - 0.11 12.6 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase APS_kinase PF01583.20 CDI85663.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase Mg_chelatase PF01078.21 CDI85663.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_17 PF13207.6 CDI85663.1 - 0.16 12.4 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CDI85663.1 - 0.24 10.5 0.0 0.38 9.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain WD40 PF00400.32 CDI85664.1 - 4.3e-14 52.7 5.8 0.014 16.2 0.6 5.5 5 1 1 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI85664.1 - 7.6e-08 32.6 0.0 0.36 11.2 0.0 4.8 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_1 PF00036.32 CDI85664.1 - 0.0027 17.1 0.0 0.0065 15.9 0.0 1.6 1 0 0 1 1 1 1 EF hand WD40_like PF17005.5 CDI85664.1 - 0.025 13.9 0.0 0.17 11.2 0.0 1.9 1 1 0 1 1 1 0 WD40-like domain PQQ PF01011.21 CDI85664.1 - 0.044 13.7 0.2 44 4.2 0.0 4.1 3 1 1 4 4 4 0 PQQ enzyme repeat PQQ_3 PF13570.6 CDI85664.1 - 2.1 9.0 4.9 18 6.0 0.0 4.3 6 0 0 6 6 6 0 PQQ-like domain AAA_22 PF13401.6 CDI85665.1 - 0.0043 17.3 0.1 0.0043 17.3 0.1 3.1 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 CDI85665.1 - 0.015 14.4 0.7 0.031 13.3 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.6 CDI85665.1 - 0.063 13.7 0.0 0.063 13.7 0.0 5.9 8 1 1 9 9 9 0 AAA ATPase domain ANAPC_CDC26 PF10471.9 CDI85666.1 - 0.037 14.8 49.0 0.76 10.7 21.7 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 RBM39linker PF15519.6 CDI85666.1 - 0.47 11.6 20.0 1.1 10.4 4.1 2.2 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein Pinin_SDK_memA PF04696.13 CDI85666.1 - 1.4 9.0 37.2 3.1 7.9 16.2 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region NinG PF05766.12 CDI85666.1 - 1.4 8.8 24.4 1.6 8.6 8.7 2.1 2 0 0 2 2 2 0 Bacteriophage Lambda NinG protein DUF572 PF04502.13 CDI85666.1 - 1.4 8.4 20.2 1.7 8.2 20.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DivIC PF04977.15 CDI85666.1 - 2.3 8.1 38.2 0.38 10.6 15.6 2.3 2 0 0 2 2 2 0 Septum formation initiator Med15 PF09606.10 CDI85666.1 - 3.1 6.4 52.3 4.3 5.9 52.3 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal MPM1 PF17234.2 CDI85666.1 - 3.3 8.0 28.5 1.8 8.8 9.5 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 MecA PF05389.12 CDI85666.1 - 4.4 6.9 18.1 0.5 10.0 5.6 2.0 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DDRGK PF09756.9 CDI85666.1 - 4.6 6.8 30.0 3.6 7.1 8.6 2.1 2 0 0 2 2 2 0 DDRGK domain MAS20 PF02064.15 CDI85666.1 - 4.9 7.3 23.4 4.1 7.5 7.0 2.2 2 0 0 2 2 2 0 MAS20 protein import receptor DUF4048 PF13257.6 CDI85666.1 - 5.1 6.8 25.6 7.5 6.3 25.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4048) XRCC4 PF06632.12 CDI85666.1 - 5.7 5.7 22.3 6.4 5.5 22.3 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF3381 PF11861.8 CDI85666.1 - 8.8 6.1 26.1 5.3 6.8 8.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) SLC12 PF03522.15 CDI85666.1 - 10 5.0 23.0 14 4.5 23.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 tRNA-synt_His PF13393.6 CDI85667.1 - 3.7e-17 62.5 0.1 3e-10 39.9 0.0 3.1 2 1 1 3 3 3 3 Histidyl-tRNA synthetase Cyclin PF08613.11 CDI85669.1 - 2.3e-06 28.1 0.1 3.7e-05 24.1 0.0 2.5 2 1 0 2 2 2 1 Cyclin Hydrolase_4 PF12146.8 CDI85671.1 - 6.9e-20 71.3 0.1 2.2e-08 33.7 0.0 3.3 3 0 0 3 3 3 3 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDI85671.1 - 0.011 16.3 10.6 0.035 14.7 10.6 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family COPI_assoc PF08507.10 CDI85672.1 - 7.1e-10 39.0 6.5 9.4e-10 38.6 6.5 1.1 1 0 0 1 1 1 1 COPI associated protein RPAP1_N PF08621.10 CDI85673.1 - 0.033 14.0 0.6 0.093 12.5 0.6 1.7 1 0 0 1 1 1 0 RPAP1-like, N-terminal XRN_N PF03159.18 CDI85675.1 - 4.2 6.7 6.5 10 5.5 6.3 1.7 1 1 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus RskA PF10099.9 CDI85678.1 - 2.3e-06 28.1 7.3 2.6e-06 27.9 7.3 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI85678.1 - 3.9e-06 26.7 17.1 4.3e-06 26.5 17.1 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Nop53 PF07767.11 CDI85678.1 - 0.012 15.1 17.4 0.014 14.8 17.4 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) TAF1D PF15333.6 CDI85678.1 - 0.027 14.2 9.9 0.031 14.0 9.9 1.1 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D MMR1 PF08505.10 CDI85678.1 - 0.03 14.6 24.0 0.035 14.4 24.0 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Spem1 PF15670.5 CDI85678.1 - 0.058 13.0 14.4 0.066 12.8 14.4 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 CCSAP PF15748.5 CDI85678.1 - 0.061 13.5 20.6 0.082 13.1 20.6 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Velvet PF11754.8 CDI85678.1 - 0.075 13.0 19.9 0.088 12.7 19.9 1.1 1 0 0 1 1 1 0 Velvet factor TCP PF03634.13 CDI85678.1 - 0.11 13.1 20.1 0.14 12.7 20.1 1.1 1 0 0 1 1 1 0 TCP family transcription factor SOBP PF15279.6 CDI85678.1 - 0.21 12.2 17.8 0.22 12.1 17.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Suf PF05843.14 CDI85678.1 - 0.22 11.5 21.3 0.25 11.3 21.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 CDI85678.1 - 0.22 11.5 37.9 0.26 11.2 37.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF572 PF04502.13 CDI85678.1 - 0.25 10.9 19.2 0.28 10.8 19.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) ArsP_2 PF11449.8 CDI85678.1 - 0.3 10.2 1.6 0.45 9.7 1.6 1.3 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter eIF-3_zeta PF05091.12 CDI85678.1 - 0.42 9.5 21.6 0.47 9.4 21.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM199X PF15814.5 CDI85678.1 - 0.52 9.3 16.8 0.61 9.1 16.8 1.2 1 0 0 1 1 1 0 Protein family FAM199X XRCC4 PF06632.12 CDI85678.1 - 0.52 9.1 16.4 0.6 8.9 16.4 1.0 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 CAC1F_C PF16885.5 CDI85678.1 - 0.53 9.9 15.1 0.56 9.8 15.1 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term SMYLE_N PF18615.1 CDI85678.1 - 0.54 9.8 16.3 0.66 9.5 16.3 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain RIFIN PF02009.16 CDI85678.1 - 0.75 9.6 13.5 0.97 9.3 13.5 1.1 1 0 0 1 1 1 0 Rifin Hydin_ADK PF17213.3 CDI85678.1 - 0.77 10.0 19.4 1.1 9.5 19.4 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain VirE_N PF08800.10 CDI85678.1 - 0.78 9.9 5.9 0.25 11.5 3.4 1.5 2 0 0 2 2 1 0 VirE N-terminal domain PA26 PF04636.13 CDI85678.1 - 1 8.2 15.2 1.1 8.1 15.2 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF1387 PF07139.11 CDI85678.1 - 1.1 8.9 21.1 1.2 8.8 21.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) SprA-related PF12118.8 CDI85678.1 - 1.3 8.1 36.2 1.6 7.8 36.2 1.0 1 0 0 1 1 1 0 SprA-related family CDC45 PF02724.14 CDI85678.1 - 1.5 7.0 14.9 1.7 6.8 14.9 1.0 1 0 0 1 1 1 0 CDC45-like protein SID-1_RNA_chan PF13965.6 CDI85678.1 - 1.6 7.1 7.2 2 6.7 7.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Neur_chan_memb PF02932.16 CDI85678.1 - 1.6 8.7 13.5 1.9 8.5 13.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI85678.1 - 1.7 7.4 24.2 2 7.1 24.2 1.1 1 0 0 1 1 1 0 Presenilin DUF853 PF05872.12 CDI85678.1 - 1.7 7.1 11.6 1.8 7.1 11.6 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) RAP1 PF07218.11 CDI85678.1 - 2 6.6 8.0 2 6.6 8.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SLC12 PF03522.15 CDI85678.1 - 2 7.4 18.1 2.2 7.2 18.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CRA PF06589.11 CDI85678.1 - 2 8.5 7.0 2.8 8.0 7.0 1.2 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) CobT PF06213.12 CDI85678.1 - 2.2 7.6 20.1 3 7.1 20.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Band_3_cyto PF07565.13 CDI85678.1 - 2.5 7.8 15.9 3.3 7.4 15.9 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain HemX PF04375.14 CDI85678.1 - 2.7 7.2 27.9 3.3 6.9 27.9 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase V_ATPase_I PF01496.19 CDI85678.1 - 2.7 5.8 13.8 3 5.6 13.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 CDI85678.1 - 2.8 7.7 17.5 3.2 7.5 17.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GREB1 PF15782.5 CDI85678.1 - 3.1 4.8 23.8 3.5 4.6 23.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAJIN PF15077.6 CDI85678.1 - 3.5 7.3 14.5 3.9 7.2 14.5 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Peptidase_S64 PF08192.11 CDI85678.1 - 3.8 5.9 18.5 4.1 5.8 18.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 Zip PF02535.22 CDI85678.1 - 4.5 6.4 12.5 5.4 6.1 12.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PAT1 PF09770.9 CDI85678.1 - 4.9 5.3 27.7 5.1 5.2 27.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NPR3 PF03666.13 CDI85678.1 - 5.4 5.7 19.7 6.3 5.5 19.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Cellulose_synt PF03552.14 CDI85678.1 - 6.4 5.1 7.8 7 5.0 7.8 1.0 1 0 0 1 1 1 0 Cellulose synthase Serinc PF03348.15 CDI85678.1 - 7.3 5.4 10.5 9.3 5.1 10.5 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Membralin PF09746.9 CDI85678.1 - 7.5 5.5 12.6 8.6 5.3 12.6 1.1 1 0 0 1 1 1 0 Tumour-associated protein Smg8_Smg9 PF10220.9 CDI85678.1 - 8.2 4.6 20.5 8.7 4.5 20.5 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Hid1 PF12722.7 CDI85678.1 - 9.1 4.3 21.0 10 4.1 21.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pribosyltran PF00156.27 CDI85679.1 - 0.41 10.2 0.0 0.41 10.2 0.0 2.5 4 0 0 4 4 4 0 Phosphoribosyl transferase domain RskA PF10099.9 CDI85679.1 - 0.59 10.4 79.1 0.13 12.5 11.3 5.1 2 2 2 4 4 4 0 Anti-sigma-K factor rskA Phage_holin_3_3 PF16083.5 CDI85679.1 - 2.2 8.4 4.4 29 4.9 0.1 3.4 3 0 0 3 3 3 0 LydA holin phage, holin superfamily III DUF3270 PF11674.8 CDI85680.1 - 0.00024 21.2 5.0 0.00024 21.2 5.0 9.0 9 3 2 11 11 11 1 Protein of unknown function (DUF3270) BacA PF02673.18 CDI85680.1 - 0.00029 20.6 0.2 0.012 15.3 0.1 2.7 2 0 0 2 2 2 1 Bacitracin resistance protein BacA DUF4834 PF16118.5 CDI85680.1 - 0.0038 18.2 7.0 0.0038 18.2 7.0 10.7 6 4 2 8 8 8 1 Domain of unknown function (DUF4834) 5TM-5TMR_LYT PF07694.12 CDI85680.1 - 0.1 12.1 1.3 0.31 10.5 1.3 1.8 1 0 0 1 1 1 0 5TMR of 5TMR-LYT CrgA PF06781.12 CDI85680.1 - 0.12 12.4 0.1 0.12 12.4 0.1 5.5 4 1 1 5 5 5 0 Cell division protein CrgA K_channel_TID PF07941.11 CDI85681.1 - 0.0034 17.8 12.8 0.0034 17.8 12.8 4.7 3 1 1 4 4 4 1 Potassium channel Kv1.4 tandem inactivation domain DUF3332 PF11810.8 CDI85681.1 - 1.8 8.2 5.5 0.5 10.0 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3332) SLC12 PF03522.15 CDI85681.1 - 2.1 7.3 17.1 2.7 6.9 17.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Robl_LC7 PF03259.17 CDI85681.1 - 2.3 8.1 8.4 9.5 6.1 0.0 2.4 2 0 0 2 2 2 0 Roadblock/LC7 domain SARAF PF06682.12 CDI85681.1 - 3.3 7.3 18.3 2.3 7.8 6.8 2.1 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis adh_short PF00106.25 CDI85682.1 - 1.9e-16 60.1 7.4 1.1e-06 28.3 0.7 4.5 4 1 1 5 5 5 2 short chain dehydrogenase adh_short_C2 PF13561.6 CDI85682.1 - 1.5e-07 31.2 9.6 0.0047 16.5 5.9 3.6 3 1 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase RskA PF10099.9 CDI85682.1 - 0.0003 21.1 23.8 0.44 10.8 5.0 3.6 2 1 0 2 2 2 2 Anti-sigma-K factor rskA GDP_Man_Dehyd PF16363.5 CDI85682.1 - 0.00068 19.1 2.0 0.073 12.5 0.3 2.4 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase Spt20 PF12090.8 CDI85682.1 - 0.0049 16.5 8.0 0.0049 16.5 8.0 2.9 3 1 0 3 3 3 2 Spt20 family SUIM_assoc PF16619.5 CDI85682.1 - 0.012 15.6 2.8 0.012 15.6 2.8 4.2 4 1 0 4 4 2 0 Unstructured region C-term to UIM in Ataxin3 SPX PF03105.19 CDI85682.1 - 0.019 14.9 1.1 0.019 14.9 1.1 2.1 1 1 0 2 2 2 0 SPX domain DUF2126 PF09899.9 CDI85682.1 - 0.093 10.8 0.5 0.15 10.1 0.5 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) PHP PF02811.19 CDI85682.1 - 0.15 12.3 2.2 0.8 10.0 2.0 2.1 1 1 1 2 2 2 0 PHP domain Epimerase PF01370.21 CDI85682.1 - 0.18 11.2 6.1 6.3 6.2 3.2 3.3 2 2 0 2 2 2 0 NAD dependent epimerase/dehydratase family Secretin_N_2 PF07655.13 CDI85682.1 - 0.49 11.0 31.9 0.12 13.0 2.1 4.1 4 0 0 4 4 4 0 Secretin N-terminal domain EPL1 PF10513.9 CDI85682.1 - 0.67 10.3 7.8 0.65 10.4 0.2 3.1 3 0 0 3 3 3 0 Enhancer of polycomb-like 2-Hacid_dh_C PF02826.19 CDI85682.1 - 1.3 8.4 4.6 5.4 6.3 0.2 2.3 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain V_ATPase_I PF01496.19 CDI85682.1 - 1.7 6.5 9.7 0.042 11.8 2.6 1.9 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family DUF2489 PF10675.9 CDI85682.1 - 4.7 7.1 18.2 4.7 7.1 2.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) DUF1635 PF07795.11 CDI85683.1 - 1 9.1 4.3 1.6 8.5 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Apt1 PF10351.9 CDI85683.1 - 2 7.2 3.4 2.5 6.9 3.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4614 PF15391.6 CDI85683.1 - 2.6 8.0 10.4 5.3 7.0 10.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Macoilin PF09726.9 CDI85683.1 - 9.8 4.6 6.4 21 3.5 6.4 1.6 1 0 0 1 1 1 0 Macoilin family MAM33 PF02330.16 CDI85684.1 - 0.013 15.4 5.3 1 9.2 0.4 2.5 2 0 0 2 2 2 0 Mitochondrial glycoprotein TFIIA PF03153.13 CDI85684.1 - 0.55 10.2 50.3 0.016 15.3 21.4 2.1 1 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Orf78 PF06024.12 CDI85684.1 - 0.7 10.2 0.0 0.7 10.2 0.0 4.0 3 1 1 5 5 5 0 Orf78 (ac78) DUF4407 PF14362.6 CDI85684.1 - 1.1 8.5 22.1 3.2 7.0 1.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Peptidase_S49_N PF08496.10 CDI85684.1 - 1.9 8.5 7.4 11 6.0 1.7 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Anoctamin PF04547.12 CDI85684.1 - 3.6 6.3 4.9 3 6.6 1.6 1.9 2 0 0 2 2 2 0 Calcium-activated chloride channel PepSY_TM PF03929.16 CDI85684.1 - 4.5 6.9 15.2 1.2 8.7 0.4 3.1 3 0 0 3 3 3 0 PepSY-associated TM region Nuc_deoxyri_tr2 PF15891.5 CDI85684.1 - 6.5 7.1 6.8 15 6.0 1.6 2.4 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like Secretin_N_2 PF07655.13 CDI85684.1 - 9.6 6.8 44.7 1.2 9.7 17.2 4.1 4 0 0 4 4 4 0 Secretin N-terminal domain DUF2722 PF10846.8 CDI85685.1 - 2.2e-05 23.6 5.1 2.2e-05 23.6 5.1 3.3 2 1 1 3 3 3 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI85685.1 - 0.00032 21.1 7.0 0.00032 21.1 7.0 6.9 3 2 1 4 4 4 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI85685.1 - 0.00079 19.1 13.8 0.00079 19.1 13.8 3.3 2 1 0 2 2 2 1 Spt20 family Suf PF05843.14 CDI85685.1 - 0.007 16.4 4.1 0.007 16.4 4.1 3.2 2 1 0 2 2 2 1 Suppressor of forked protein (Suf) Presenilin PF01080.17 CDI85685.1 - 0.057 12.2 44.2 0.38 9.5 32.4 2.2 2 0 0 2 2 2 0 Presenilin FAM60A PF15396.6 CDI85685.1 - 0.07 13.1 30.8 0.99 9.4 0.4 2.3 2 0 0 2 2 2 0 Protein Family FAM60A BAF1_ABF1 PF04684.13 CDI85685.1 - 1.3 8.0 29.9 0.11 11.5 16.3 2.7 3 0 0 3 3 3 0 BAF1 / ABF1 chromatin reorganising factor SLC12 PF03522.15 CDI85685.1 - 1.4 7.8 39.8 1.3 8.0 0.6 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Draxin PF15550.6 CDI85685.1 - 9.1 6.0 24.4 15 5.4 0.4 2.7 2 0 0 2 2 2 0 Draxin RNA_GG_bind PF10258.9 CDI85687.1 - 1.6 8.9 16.1 1.8 8.7 1.3 3.7 2 1 1 3 3 3 0 PHAX RNA-binding domain Grg1 PF11034.8 CDI85687.1 - 1.6 9.0 37.4 1.5 9.1 0.7 5.7 1 1 3 4 4 4 0 Glucose-repressible protein Grg1 TFIIA PF03153.13 CDI85687.1 - 7.4 6.4 83.4 0.1 12.6 21.6 3.1 2 1 1 3 3 3 0 Transcription factor IIA, alpha/beta subunit MgtE_N PF03448.17 CDI85687.1 - 7.7 7.2 10.4 1.1 10.0 1.1 3.2 2 1 1 3 3 3 0 MgtE intracellular N domain SR-25 PF10500.9 CDI85688.1 - 0.0091 15.6 9.4 0.011 15.4 9.4 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein RNaseH_pPIWI_RE PF13032.6 CDI85688.1 - 0.039 13.9 0.0 0.039 13.9 0.0 1.0 1 0 0 1 1 1 0 RNaseH domain of pPIWI_RE SARAF PF06682.12 CDI85689.1 - 0.81 9.3 29.5 28 4.2 0.0 3.0 1 1 2 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis ERGIC_N PF13850.6 CDI85690.1 - 0.15 12.4 0.2 0.41 11.0 0.0 1.8 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Stevor PF17410.2 CDI85690.1 - 0.32 10.5 7.7 0.42 10.1 7.7 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF726 PF05277.12 CDI85690.1 - 1.1 8.1 11.7 1.4 7.7 11.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) FSA_C PF10479.9 CDI85690.1 - 4.1 5.4 12.7 4.7 5.2 12.7 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus TFIIA PF03153.13 CDI85690.1 - 5.4 6.9 5.0 6.9 6.6 5.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI85691.1 - 0.0099 15.9 8.3 0.0099 15.9 8.3 4.7 3 2 1 4 4 1 1 Unstructured region C-term to UIM in Ataxin3 EPL1 PF10513.9 CDI85691.1 - 0.022 15.1 12.9 0.14 12.5 3.9 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like ANAPC_CDC26 PF10471.9 CDI85691.1 - 0.052 14.4 9.1 0.052 14.4 9.1 3.3 2 1 1 3 3 2 0 Anaphase-promoting complex APC subunit CDC26 DUF4647 PF15504.6 CDI85691.1 - 0.14 11.2 22.0 0.22 10.6 11.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) Siah-Interact_N PF09032.11 CDI85691.1 - 0.17 12.2 22.9 0.33 11.3 3.8 3.4 3 0 0 3 3 3 0 Siah interacting protein, N terminal RRN9 PF10680.9 CDI85691.1 - 1.4 9.3 15.7 2.9 8.3 0.9 3.2 3 0 0 3 3 3 0 RNA polymerase I specific transcription initiation factor Hydin_ADK PF17213.3 CDI85691.1 - 1.4 9.1 22.4 2.6 8.3 12.9 2.6 2 1 0 2 2 2 0 Hydin Adenylate kinase-like domain DUF4366 PF14283.6 CDI85691.1 - 2.7 8.0 9.5 6.6 6.8 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) CDK2AP PF09806.9 CDI85691.1 - 4.3 7.4 23.1 1.3 9.0 5.2 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein DUF2722 PF10846.8 CDI85691.1 - 7.6 5.4 46.5 2.6 6.9 3.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Kinesin_assoc PF16183.5 CDI85691.1 - 9.7 6.3 6.2 10 6.2 1.4 2.3 2 1 0 2 2 2 0 Kinesin-associated Caldesmon PF02029.15 CDI85692.1 - 0.00027 19.8 4.0 0.00027 19.8 4.0 2.9 3 1 0 3 3 3 1 Caldesmon Presenilin PF01080.17 CDI85693.1 - 2.5 6.8 29.6 2.4 6.9 5.6 2.5 2 0 0 2 2 2 0 Presenilin Serinc PF03348.15 CDI85693.1 - 4 6.3 10.6 0.8 8.6 1.3 2.3 2 0 0 2 2 2 0 Serine incorporator (Serinc) RPN2_C PF18004.1 CDI85693.1 - 6.1 6.7 24.4 4.7 7.1 1.8 2.5 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain TRAP_alpha PF03896.16 CDI85693.1 - 6.3 5.9 13.8 5.7 6.1 0.4 2.8 3 0 0 3 3 3 0 Translocon-associated protein (TRAP), alpha subunit Mucin PF01456.17 CDI85694.1 - 0.00033 20.7 0.7 0.00033 20.7 0.7 2.0 2 0 0 2 2 1 1 Mucin-like glycoprotein Cyclin_C PF02984.19 CDI85694.1 - 0.0037 17.3 4.4 0.0037 17.3 4.4 2.2 1 1 1 2 2 2 1 Cyclin, C-terminal domain PAT1 PF09770.9 CDI85694.1 - 0.0053 15.1 19.2 0.0057 15.0 19.2 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 DUF4179 PF13786.6 CDI85694.1 - 0.052 14.0 1.5 6.9 7.2 0.0 3.0 3 1 0 3 3 2 0 Domain of unknown function (DUF4179) Otopetrin PF03189.13 CDI85694.1 - 0.27 10.0 2.5 0.38 9.5 2.5 1.3 1 0 0 1 1 1 0 Otopetrin SART-1 PF03343.13 CDI85694.1 - 0.32 9.5 19.8 0.46 9.0 19.8 1.1 1 0 0 1 1 1 0 SART-1 family O-antigen_lig PF13425.6 CDI85694.1 - 0.43 9.3 2.8 0.58 8.9 2.8 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Baculo_PP31 PF05311.11 CDI85694.1 - 0.51 9.8 7.8 0.77 9.2 7.8 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) THOC2_N PF16134.5 CDI85694.1 - 0.86 8.2 12.5 1.3 7.5 12.5 1.3 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Presenilin PF01080.17 CDI85694.1 - 1.5 7.5 23.0 0.067 12.0 15.4 1.9 2 0 0 2 2 2 0 Presenilin SID-1_RNA_chan PF13965.6 CDI85694.1 - 3.2 6.1 5.7 3.3 6.0 5.7 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 GREB1 PF15782.5 CDI85694.1 - 5.1 4.1 17.4 6.2 3.8 17.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Nop14 PF04147.12 CDI85695.1 - 7.6 4.6 16.3 8.6 4.4 16.3 1.0 1 0 0 1 1 1 0 Nop14-like family Nucleoporin_FG PF13634.6 CDI85696.1 - 7.7e-37 126.0 192.4 1.3e-10 41.9 40.5 6.0 1 1 5 6 6 6 6 Nucleoporin FG repeat region DUF2076 PF09849.9 CDI85697.1 - 0.18 11.8 18.6 0.2 11.7 18.6 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Spt20 PF12090.8 CDI85697.1 - 0.35 10.4 25.7 0.4 10.3 25.7 1.1 1 0 0 1 1 1 0 Spt20 family SpoIIP PF07454.11 CDI85697.1 - 0.5 9.8 6.0 0.5 9.8 6.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TFIIA PF03153.13 CDI85697.1 - 0.56 10.1 20.8 0.57 10.1 20.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CCDC53 PF10152.9 CDI85697.1 - 0.68 10.3 8.7 0.71 10.3 8.7 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Coilin_N PF15862.5 CDI85697.1 - 0.7 9.7 9.5 0.81 9.5 9.5 1.1 1 0 0 1 1 1 0 Coilin N-terminus Presenilin PF01080.17 CDI85697.1 - 0.82 8.4 6.3 0.77 8.5 6.3 1.0 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CDI85697.1 - 0.9 10.5 8.5 1.1 10.3 8.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Roughex PF06020.11 CDI85697.1 - 1.2 8.2 15.4 1.2 8.2 15.4 1.0 1 0 0 1 1 1 0 Drosophila roughex protein DUF3464 PF11947.8 CDI85697.1 - 1.6 8.5 9.2 1.9 8.2 9.2 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF3043 PF11241.8 CDI85697.1 - 1.8 8.6 7.7 2.1 8.4 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF4407 PF14362.6 CDI85697.1 - 1.9 7.7 6.2 1.7 7.9 6.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0560 PF10577.9 CDI85697.1 - 3.8 5.9 12.3 3.4 6.0 12.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Ctr PF04145.15 CDI85697.1 - 5.3 7.6 4.7 5.8 7.5 4.7 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Sec20 PF03908.13 CDI85698.1 - 0.0016 18.3 2.7 0.0016 18.3 2.7 2.7 2 1 2 4 4 4 1 Sec20 AAA_11 PF13086.6 CDI85698.1 - 0.0032 17.3 5.0 0.0032 17.3 5.0 2.1 2 0 0 2 2 2 1 AAA domain CCSAP PF15748.5 CDI85698.1 - 1.6 8.8 29.3 2.1 8.5 8.1 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DNA_pol_A PF00476.20 CDI85699.1 - 1.4e-12 47.4 0.0 1.4e-12 47.4 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase family A DUF2722 PF10846.8 CDI85699.1 - 0.0025 16.8 16.5 0.0025 16.8 16.5 3.7 4 0 0 4 4 4 2 Protein of unknown function (DUF2722) EPL1 PF10513.9 CDI85699.1 - 0.053 13.9 22.5 0.47 10.8 5.9 4.2 4 0 0 4 4 4 0 Enhancer of polycomb-like SAPS PF04499.15 CDI85699.1 - 0.19 10.5 9.4 1.8 7.2 8.4 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Med15 PF09606.10 CDI85699.1 - 0.97 8.0 59.4 0.01 14.6 47.4 2.6 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF572 PF04502.13 CDI85699.1 - 1.5 8.4 22.8 0.015 14.9 9.1 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF572) Ndc1_Nup PF09531.10 CDI85699.1 - 3.6 6.2 26.4 6 5.4 0.1 2.4 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup TCP PF03634.13 CDI85699.1 - 8.8 6.9 33.2 1.7 9.2 1.8 4.3 4 0 0 4 4 4 0 TCP family transcription factor Thioredoxin PF00085.20 CDI85701.1 - 1.2e-38 131.2 0.0 1e-20 73.6 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 CDI85701.1 - 4.5e-11 43.0 0.0 2.9e-06 27.3 0.0 3.5 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CDI85701.1 - 0.00078 19.9 0.0 0.16 12.4 0.0 3.1 2 1 0 2 2 2 1 Thioredoxin-like domain AhpC-TSA PF00578.21 CDI85701.1 - 0.028 14.4 0.0 2.9 7.8 0.0 2.7 2 0 0 2 2 2 0 AhpC/TSA family Thioredoxin_8 PF13905.6 CDI85701.1 - 0.12 12.8 0.0 29 5.1 0.0 2.7 2 0 0 2 2 2 0 Thioredoxin-like RCC1 PF00415.18 CDI85702.1 - 1.3e-61 205.0 46.5 2.1e-13 50.7 1.2 8.6 7 2 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDI85702.1 - 9.5e-41 136.8 49.5 7.5e-09 35.2 0.9 8.5 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 CDI85702.1 - 8.5e-06 25.6 0.3 5.6 6.6 0.0 5.0 5 0 0 5 5 5 2 TUP1-like enhancer of split Kelch_2 PF07646.15 CDI85702.1 - 0.0039 17.1 6.4 23 5.2 0.1 5.8 7 0 0 7 7 7 1 Kelch motif Peptidase_M36 PF02128.15 CDI85703.1 - 0.84 8.7 8.1 0.98 8.5 8.1 1.1 1 0 0 1 1 1 0 Fungalysin metallopeptidase (M36) Tfb4 PF03850.14 CDI85703.1 - 2.8 7.4 17.9 3.4 7.1 17.9 1.1 1 0 0 1 1 1 0 Transcription factor Tfb4 SmpB PF01668.18 CDI85703.1 - 6.1 6.7 14.2 1.3 8.8 6.5 2.1 2 0 0 2 2 2 0 SmpB protein Ribosomal_60s PF00428.19 CDI85705.1 - 0.13 12.9 24.2 0.45 11.1 13.4 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Hamartin PF04388.12 CDI85705.1 - 1 8.0 24.8 1.2 7.7 24.8 1.1 1 0 0 1 1 1 0 Hamartin protein Macoilin PF09726.9 CDI85705.1 - 1.9 7.0 41.4 2.6 6.5 41.4 1.1 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI85705.1 - 4.5 7.2 56.7 7.6 6.4 56.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4746 PF15928.5 CDI85706.1 - 0.29 10.5 12.1 0.29 10.5 12.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF3112 PF11309.8 CDI85706.1 - 2.5 7.5 5.0 2.6 7.5 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) SpoIIP PF07454.11 CDI85706.1 - 3.1 7.2 16.9 3.1 7.2 16.9 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF3292 PF11696.8 CDI85706.1 - 3.8 5.8 11.2 4.1 5.7 11.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF3408 PF11888.8 CDI85706.1 - 4 7.6 15.9 4.1 7.5 15.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Pex14_N PF04695.13 CDI85706.1 - 4.3 8.0 27.7 4.3 8.0 27.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Band_3_cyto PF07565.13 CDI85706.1 - 4.7 6.9 14.9 4.7 6.9 14.9 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Connexin PF00029.19 CDI85706.1 - 5.5 6.7 11.4 5.2 6.8 11.4 1.1 1 0 0 1 1 1 0 Connexin G0-G1_switch_2 PF15103.6 CDI85706.1 - 5.8 7.4 12.1 7.5 7.0 12.1 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 CPSF100_C PF13299.6 CDI85706.1 - 6.7 6.9 13.2 6.7 6.9 13.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal REC114-like PF15165.6 CDI85706.1 - 7.4 6.3 18.7 7.2 6.3 18.7 1.0 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like Sec62 PF03839.16 CDI85706.1 - 7.6 6.0 10.6 7.2 6.1 10.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DUF3464 PF11947.8 CDI85706.1 - 7.6 6.3 14.6 8.1 6.2 14.6 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Peptidase_S49_N PF08496.10 CDI85706.1 - 7.9 6.5 12.4 8.6 6.4 12.4 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Endostatin PF06482.11 CDI85706.1 - 8.1 5.8 17.2 8.2 5.8 17.2 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CCDC53 PF10152.9 CDI85706.1 - 8.4 6.8 19.5 9.2 6.7 19.5 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DDHD PF02862.17 CDI85706.1 - 9.5 6.3 14.3 9.3 6.3 14.3 1.1 1 0 0 1 1 1 0 DDHD domain SPX PF03105.19 CDI85707.1 - 0.001 19.1 6.7 0.001 19.1 6.7 8.8 5 1 1 6 6 6 3 SPX domain PGAP1 PF07819.13 CDI85707.1 - 0.0013 18.5 0.3 0.0013 18.5 0.3 2.9 2 0 0 2 2 2 1 PGAP1-like protein SUIM_assoc PF16619.5 CDI85708.1 - 0.011 15.8 5.2 0.011 15.8 5.2 8.4 4 2 2 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 DUF4050 PF13259.6 CDI85708.1 - 0.02 15.2 12.2 0.02 15.2 12.2 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4050) SLC12 PF03522.15 CDI85708.1 - 0.68 8.9 27.6 0.18 10.8 17.0 2.2 2 0 0 2 2 2 0 Solute carrier family 12 Glyphos_transf PF04464.14 CDI85708.1 - 1.3 7.9 6.6 2.9 6.8 6.6 1.5 1 0 0 1 1 1 0 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase SID-1_RNA_chan PF13965.6 CDI85708.1 - 4 5.7 12.4 0.35 9.2 6.7 1.9 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 7TM_GPCR_Srv PF10323.9 CDI85710.1 - 0.01 15.2 4.2 0.4 10.0 0.0 2.2 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv Arteri_nucleo PF01481.16 CDI85710.1 - 0.027 14.7 8.9 0.047 14.0 8.9 1.5 1 0 0 1 1 1 0 Arterivirus nucleocapsid protein RskA PF10099.9 CDI85710.1 - 0.038 14.3 0.6 0.057 13.7 0.6 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI85710.1 - 3.5 6.5 18.1 4.4 6.2 18.1 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 RAP1 PF07218.11 CDI85711.1 - 0.048 11.9 29.4 0.097 10.9 1.3 2.1 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) DUF572 PF04502.13 CDI85711.1 - 0.11 12.1 34.1 0.15 11.7 34.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Utp14 PF04615.13 CDI85711.1 - 2.1 6.8 34.7 2.8 6.4 34.7 1.1 1 0 0 1 1 1 0 Utp14 protein SARAF PF06682.12 CDI85712.1 - 2.1e-05 24.3 7.5 0.00096 18.9 0.0 2.5 1 1 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis DUF2722 PF10846.8 CDI85712.1 - 3.5e-05 22.9 4.8 3.5e-05 22.9 4.8 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2722) SID-1_RNA_chan PF13965.6 CDI85712.1 - 0.004 15.6 0.8 0.012 14.0 0.8 1.7 1 1 0 1 1 1 1 dsRNA-gated channel SID-1 TCP PF03634.13 CDI85712.1 - 0.0048 17.5 6.0 1.5 9.4 0.0 2.2 2 0 0 2 2 2 2 TCP family transcription factor DDHD PF02862.17 CDI85712.1 - 0.0061 16.8 6.1 0.25 11.5 0.7 2.1 2 0 0 2 2 2 2 DDHD domain Dpy19 PF10034.9 CDI85712.1 - 0.018 13.3 1.7 0.063 11.5 0.0 1.9 2 0 0 2 2 2 0 Q-cell neuroblast polarisation DUF4658 PF15555.6 CDI85712.1 - 0.021 15.0 0.0 0.021 15.0 0.0 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF4658) MAM33 PF02330.16 CDI85712.1 - 0.021 14.8 13.7 0.1 12.6 0.9 2.2 2 0 0 2 2 2 0 Mitochondrial glycoprotein Tim54 PF11711.8 CDI85712.1 - 0.041 12.7 9.1 0.23 10.2 1.3 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 RIC3 PF15361.6 CDI85712.1 - 0.043 14.2 7.2 0.071 13.5 0.3 2.2 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 EPL1 PF10513.9 CDI85712.1 - 0.046 14.1 14.8 0.093 13.1 1.9 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like CAF1 PF04857.20 CDI85712.1 - 0.049 12.8 2.8 0.11 11.7 2.8 1.5 1 1 0 1 1 1 0 CAF1 family ribonuclease DUF808 PF05661.12 CDI85712.1 - 0.073 12.1 4.1 0.37 9.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF808) TFIIA PF03153.13 CDI85712.1 - 0.08 12.9 41.1 0.64 10.0 16.1 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI85712.1 - 0.1 11.2 40.8 0.16 10.6 13.0 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal AIF_C PF14721.6 CDI85712.1 - 0.12 12.7 8.5 0.48 10.8 0.6 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term 7TM_GPCR_Str PF10326.9 CDI85712.1 - 0.13 11.6 6.8 0.19 11.1 6.8 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Str DUF4484 PF14831.6 CDI85712.1 - 0.19 11.7 10.5 1.1 9.3 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) PA26 PF04636.13 CDI85712.1 - 0.2 10.5 10.2 0.35 9.7 1.5 2.0 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) CSG2 PF16965.5 CDI85712.1 - 0.39 9.6 8.4 0.24 10.3 2.2 2.0 2 0 0 2 2 2 0 Ceramide synthase regulator SelK_SelG PF10961.8 CDI85712.1 - 0.4 11.3 0.1 0.4 11.3 0.1 2.6 3 0 0 3 3 2 0 Selenoprotein SelK_SelG Anoctamin PF04547.12 CDI85712.1 - 0.42 9.4 6.4 0.34 9.7 1.9 2.0 2 0 0 2 2 2 0 Calcium-activated chloride channel Mak16 PF04874.14 CDI85712.1 - 0.5 11.0 14.3 2.2 8.9 3.9 2.2 2 0 0 2 2 2 0 Mak16 protein C-terminal region Shisa PF13908.6 CDI85712.1 - 0.55 10.5 10.3 0.83 9.9 0.2 2.3 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF4199 PF13858.6 CDI85712.1 - 0.76 10.2 13.0 0.31 11.4 4.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) SpoIIP PF07454.11 CDI85712.1 - 0.88 9.0 16.0 0.35 10.3 3.5 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF853 PF05872.12 CDI85712.1 - 1.3 7.5 12.3 0.32 9.5 2.1 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) CPSF100_C PF13299.6 CDI85712.1 - 1.5 9.0 13.9 3.9 7.6 2.7 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FAM60A PF15396.6 CDI85712.1 - 1.6 8.6 10.1 1.2 9.1 1.4 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Peptidase_U57 PF05582.12 CDI85712.1 - 2.1 7.5 11.3 0.7 9.1 1.0 2.1 2 0 0 2 2 2 0 YabG peptidase U57 ARD PF03079.14 CDI85712.1 - 2.3 8.4 10.2 0.33 11.1 2.5 2.1 2 0 0 2 2 2 0 ARD/ARD' family MCU PF04678.13 CDI85712.1 - 2.3 8.3 12.0 1.2 9.2 0.4 2.2 2 0 0 2 2 2 0 Mitochondrial calcium uniporter E7 PF00527.18 CDI85712.1 - 2.5 8.3 14.9 5.7 7.2 4.5 2.4 2 0 0 2 2 2 0 E7 protein, Early protein DUF3306 PF11748.8 CDI85712.1 - 2.6 9.0 14.8 5.2 8.0 3.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Hydin_ADK PF17213.3 CDI85712.1 - 2.7 8.2 14.4 2.8 8.2 3.1 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain AUX_IAA PF02309.16 CDI85712.1 - 4 7.2 8.6 24 4.7 8.6 1.9 1 1 0 1 1 1 0 AUX/IAA family DUF3408 PF11888.8 CDI85712.1 - 4.2 7.5 20.4 3.2 7.9 4.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) LRRC37AB_C PF14914.6 CDI85712.1 - 4.4 7.2 15.6 0.86 9.5 5.1 2.2 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain MPM1 PF17234.2 CDI85712.1 - 5 7.3 19.7 3.8 7.7 3.5 2.3 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Folliculin PF11704.8 CDI85712.1 - 5.1 6.9 11.1 3.8 7.4 2.1 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport TMEM51 PF15345.6 CDI85712.1 - 5.7 6.7 20.3 5.7 6.7 6.8 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 DUF2828 PF11443.8 CDI85712.1 - 5.7 4.9 12.6 15 3.5 12.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF2828) Otopetrin PF03189.13 CDI85712.1 - 6.5 5.5 8.1 3.4 6.4 0.7 1.9 1 1 0 2 2 2 0 Otopetrin V_ATPase_I PF01496.19 CDI85712.1 - 6.8 4.5 15.1 0.33 8.8 1.3 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family RuvC_III PF18541.1 CDI85712.1 - 6.9 6.6 12.4 3.7 7.5 0.6 2.1 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 eIF-3_zeta PF05091.12 CDI85712.1 - 7 5.5 19.6 5.2 5.9 4.7 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CobT PF06213.12 CDI85712.1 - 7.2 5.9 25.1 4.1 6.7 6.7 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DIE2_ALG10 PF04922.12 CDI85712.1 - 7.2 5.8 8.3 0.53 9.5 2.1 1.8 2 0 0 2 2 2 0 DIE2/ALG10 family DUF1840 PF08895.11 CDI85712.1 - 7.5 6.9 14.4 4.5 7.7 2.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) PepSY_TM PF03929.16 CDI85712.1 - 7.7 6.1 8.8 9.4 5.8 0.1 2.3 2 0 0 2 2 2 0 PepSY-associated TM region FPN1 PF06963.12 CDI85712.1 - 7.7 4.9 7.9 2.9 6.4 1.3 2.1 2 0 0 2 2 2 0 Ferroportin1 (FPN1) CagX PF03524.15 CDI85712.1 - 7.8 6.2 13.0 2.8 7.6 3.6 2.2 2 0 0 2 2 2 0 Conjugal transfer protein G0-G1_switch_2 PF15103.6 CDI85712.1 - 8.7 6.8 15.4 9.5 6.7 3.5 2.3 2 0 0 2 2 2 0 G0/G1 switch protein 2 DUF719 PF05334.13 CDI85712.1 - 9 6.5 16.6 9.4 6.4 5.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF719) Thg1C PF14413.6 CDI85712.1 - 9.4 6.4 16.0 8.3 6.6 5.3 2.3 2 0 0 2 2 2 0 Thg1 C terminal domain DUF4770 PF15994.5 CDI85712.1 - 9.6 6.4 19.0 6.5 7.0 6.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) TFIIA PF03153.13 CDI85714.1 - 0.0025 17.9 35.7 0.0025 17.9 35.7 2.0 1 1 1 2 2 2 1 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.19 CDI85714.1 - 0.0079 16.8 14.7 0.0079 16.8 14.7 3.3 2 1 1 3 3 3 1 60s Acidic ribosomal protein CDC27 PF09507.10 CDI85714.1 - 0.087 12.2 39.9 0.11 11.9 39.9 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Shadoo PF14999.6 CDI85714.1 - 2.1 8.5 10.6 0.23 11.5 3.8 2.2 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Presenilin PF01080.17 CDI85715.1 - 0.0009 18.1 14.9 0.0009 18.1 14.9 1.1 1 0 0 1 1 1 1 Presenilin Connexin PF00029.19 CDI85715.1 - 0.001 18.9 9.7 0.0013 18.5 9.7 1.2 1 0 0 1 1 1 1 Connexin DUF3987 PF13148.6 CDI85715.1 - 0.0043 16.1 6.7 0.005 15.9 6.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3987) Myc_N PF01056.18 CDI85715.1 - 0.0047 16.9 8.6 0.0049 16.8 8.6 1.1 1 0 0 1 1 1 1 Myc amino-terminal region DUF913 PF06025.12 CDI85715.1 - 0.005 15.9 8.6 0.0049 15.9 8.6 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) SpoIIP PF07454.11 CDI85715.1 - 0.0053 16.3 17.5 0.0056 16.2 17.5 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) TRAP_alpha PF03896.16 CDI85715.1 - 0.007 15.6 7.9 0.0077 15.5 7.9 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit V_ATPase_I PF01496.19 CDI85715.1 - 0.0076 14.2 17.8 0.0081 14.1 17.8 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family RNA_pol_Rpc4 PF05132.14 CDI85715.1 - 0.0089 16.5 10.7 0.01 16.3 10.7 1.1 1 0 0 1 1 1 1 RNA polymerase III RPC4 DUF2828 PF11443.8 CDI85715.1 - 0.0097 14.0 15.1 0.011 13.9 15.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) CLN3 PF02487.17 CDI85715.1 - 0.01 14.9 11.0 0.0098 15.0 11.0 1.0 1 0 0 1 1 1 0 CLN3 protein CPSF100_C PF13299.6 CDI85715.1 - 0.012 15.8 12.5 0.013 15.7 12.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal PIP5K PF01504.18 CDI85715.1 - 0.013 14.8 14.2 0.015 14.5 14.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Folate_carrier PF01770.18 CDI85715.1 - 0.013 14.3 7.6 0.017 13.9 7.6 1.3 1 0 0 1 1 1 0 Reduced folate carrier Afi1 PF07792.12 CDI85715.1 - 0.014 15.9 14.7 0.015 15.8 14.7 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2052 PF09747.9 CDI85715.1 - 0.016 15.4 20.5 0.018 15.2 20.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF5308 PF17233.2 CDI85715.1 - 0.019 15.2 10.5 0.021 15.1 10.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF4746 PF15928.5 CDI85715.1 - 0.02 14.3 16.1 0.023 14.1 16.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RR_TM4-6 PF06459.12 CDI85715.1 - 0.021 14.7 18.0 0.023 14.5 18.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.8 CDI85715.1 - 0.021 13.7 14.6 0.021 13.7 14.6 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4820 PF16091.5 CDI85715.1 - 0.022 14.1 11.5 0.027 13.9 11.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DDHD PF02862.17 CDI85715.1 - 0.022 14.9 12.7 0.022 14.9 12.7 1.1 1 0 0 1 1 1 0 DDHD domain eIF-3_zeta PF05091.12 CDI85715.1 - 0.025 13.6 19.4 0.028 13.4 19.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3408 PF11888.8 CDI85715.1 - 0.029 14.5 19.0 0.032 14.4 19.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) SID-1_RNA_chan PF13965.6 CDI85715.1 - 0.03 12.7 7.4 0.03 12.7 7.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 CDI85715.1 - 0.043 12.8 7.9 0.043 12.8 7.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Pap_E4 PF02711.14 CDI85715.1 - 0.05 14.6 13.0 0.063 14.2 13.0 1.3 1 0 0 1 1 1 0 E4 protein TFIIA PF03153.13 CDI85715.1 - 0.054 13.5 38.5 0.056 13.4 38.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3295 PF11702.8 CDI85715.1 - 0.058 12.8 15.1 0.059 12.7 15.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) SLC12 PF03522.15 CDI85715.1 - 0.059 12.4 14.8 0.058 12.4 14.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RPN2_C PF18004.1 CDI85715.1 - 0.061 13.2 16.9 0.076 12.9 16.9 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF1180 PF06679.12 CDI85715.1 - 0.075 13.5 4.3 0.091 13.2 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) CBP_BcsG PF11658.8 CDI85715.1 - 0.076 11.4 11.3 0.083 11.3 11.3 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DUF5523 PF17661.1 CDI85715.1 - 0.082 12.6 21.1 0.097 12.3 21.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) EOS1 PF12326.8 CDI85715.1 - 0.086 12.8 5.8 0.09 12.7 5.8 1.1 1 0 0 1 1 1 0 N-glycosylation protein Baculo_PP31 PF05311.11 CDI85715.1 - 0.093 12.2 11.7 0.099 12.1 11.7 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) NPR3 PF03666.13 CDI85715.1 - 0.096 11.5 14.9 0.1 11.3 14.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Velvet PF11754.8 CDI85715.1 - 0.12 12.3 13.6 0.13 12.2 13.6 1.0 1 0 0 1 1 1 0 Velvet factor CDC45 PF02724.14 CDI85715.1 - 0.14 10.4 15.9 0.16 10.2 15.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.8 CDI85715.1 - 0.15 10.8 17.9 0.17 10.7 17.9 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4045 PF13254.6 CDI85715.1 - 0.15 11.7 13.1 0.16 11.6 13.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) ATAD4 PF15321.6 CDI85715.1 - 0.16 13.3 10.0 0.26 12.7 10.0 1.4 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 ALMT PF11744.8 CDI85715.1 - 0.17 10.7 12.0 0.17 10.7 12.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter TCP PF03634.13 CDI85715.1 - 0.17 12.5 15.7 0.19 12.3 15.7 1.1 1 0 0 1 1 1 0 TCP family transcription factor Endostatin PF06482.11 CDI85715.1 - 0.17 11.3 14.8 0.17 11.3 14.8 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin YfhO PF09586.10 CDI85715.1 - 0.18 10.0 5.8 0.18 10.0 5.8 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF3306 PF11748.8 CDI85715.1 - 0.18 12.7 15.7 0.21 12.4 15.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) LAG1-DNAbind PF09271.11 CDI85715.1 - 0.19 12.4 12.4 0.22 12.1 12.4 1.1 1 0 0 1 1 1 0 LAG1, DNA binding Serinc PF03348.15 CDI85715.1 - 0.19 10.6 10.3 0.2 10.6 10.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) OATP PF03137.20 CDI85715.1 - 0.2 9.9 7.1 0.2 9.9 7.1 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family MMU163 PF17119.5 CDI85715.1 - 0.22 10.6 5.4 0.24 10.5 5.4 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Band_3_cyto PF07565.13 CDI85715.1 - 0.23 11.2 16.3 0.26 11.0 16.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Eapp_C PF10238.9 CDI85715.1 - 0.25 11.4 20.3 0.32 11.1 20.3 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein PAT1 PF09770.9 CDI85715.1 - 0.26 9.5 26.2 0.26 9.5 26.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GNAT_acetyltr_2 PF13718.6 CDI85715.1 - 0.27 10.6 11.2 0.33 10.3 11.2 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 FAM176 PF14851.6 CDI85715.1 - 0.31 10.7 13.4 0.49 10.0 13.4 1.3 1 0 0 1 1 1 0 FAM176 family Pex14_N PF04695.13 CDI85715.1 - 0.32 11.7 25.4 0.36 11.5 25.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PPL5 PF18168.1 CDI85715.1 - 0.32 10.2 14.7 0.4 9.9 14.7 1.1 1 0 0 1 1 1 0 Prim-pol family 5 BORG_CEP PF14957.6 CDI85715.1 - 0.36 12.0 11.5 0.4 11.8 11.5 1.1 1 0 0 1 1 1 0 Cdc42 effector CCDC53 PF10152.9 CDI85715.1 - 0.36 11.2 20.8 0.46 10.9 20.8 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Peptidase_S49_N PF08496.10 CDI85715.1 - 0.39 10.8 15.7 0.47 10.5 15.7 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4647 PF15504.6 CDI85715.1 - 0.41 9.7 19.8 0.44 9.6 19.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) dsRBD2 PF17842.1 CDI85715.1 - 0.45 10.7 12.2 0.6 10.3 12.2 1.3 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 EPL1 PF10513.9 CDI85715.1 - 0.48 10.8 19.3 0.66 10.3 19.3 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like PRC2_HTH_1 PF18118.1 CDI85715.1 - 0.51 11.2 13.3 0.66 10.8 13.3 1.3 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain CobT PF06213.12 CDI85715.1 - 0.52 9.6 34.5 0.64 9.3 34.5 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Neur_chan_memb PF02932.16 CDI85715.1 - 0.55 10.3 14.6 0.6 10.1 14.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Tmp39 PF10271.9 CDI85715.1 - 0.55 9.2 5.8 0.54 9.2 5.8 1.0 1 0 0 1 1 1 0 Putative transmembrane protein Scs3p PF10261.9 CDI85715.1 - 0.57 9.6 5.2 0.63 9.5 5.2 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF2072 PF09845.9 CDI85715.1 - 0.58 10.4 14.9 0.76 10.0 14.9 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein XRN_M PF17846.1 CDI85715.1 - 0.59 9.0 11.8 0.71 8.8 11.8 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Pox_Ag35 PF03286.14 CDI85715.1 - 0.59 9.9 12.8 0.65 9.8 12.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM60A PF15396.6 CDI85715.1 - 0.6 10.1 13.3 0.7 9.9 13.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Membralin PF09746.9 CDI85715.1 - 0.61 9.1 12.5 0.63 9.0 12.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein DDRGK PF09756.9 CDI85715.1 - 0.65 9.6 35.0 0.81 9.2 35.0 1.1 1 0 0 1 1 1 0 DDRGK domain Dynamin_N PF00350.23 CDI85715.1 - 0.65 10.0 10.0 0.64 10.0 10.0 1.1 1 0 0 1 1 1 0 Dynamin family DUF4050 PF13259.6 CDI85715.1 - 0.74 10.1 14.8 0.8 10.0 14.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) AIF_C PF14721.6 CDI85715.1 - 0.82 10.0 16.8 1.2 9.5 16.8 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Ctr PF04145.15 CDI85715.1 - 0.82 10.3 8.2 0.89 10.2 8.2 1.2 1 0 0 1 1 1 0 Ctr copper transporter family DUF4175 PF13779.6 CDI85715.1 - 0.85 7.5 40.0 0.86 7.4 40.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Mem_trans PF03547.18 CDI85715.1 - 0.89 7.9 6.3 0.95 7.8 6.3 1.1 1 0 0 1 1 1 0 Membrane transport protein Pinin_SDK_memA PF04696.13 CDI85715.1 - 0.99 9.5 35.8 1.4 9.0 35.8 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region BBL5 PF07289.11 CDI85715.1 - 1 8.3 11.9 1.2 8.1 11.9 1.1 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein DREPP PF05558.12 CDI85715.1 - 1.1 9.1 8.1 1.2 9.0 8.1 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide F-protein PF00469.20 CDI85715.1 - 1.1 8.8 16.8 1.2 8.7 16.8 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Peptidase_S64 PF08192.11 CDI85715.1 - 1.1 7.6 15.7 1.2 7.5 15.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 Peptidase_U57 PF05582.12 CDI85715.1 - 1.3 8.2 12.6 1.4 8.1 12.6 1.1 1 0 0 1 1 1 0 YabG peptidase U57 TERB2 PF15101.6 CDI85715.1 - 1.4 9.0 26.3 1.6 8.7 26.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF2126 PF09899.9 CDI85715.1 - 1.5 6.8 15.4 1.5 6.8 15.4 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) MDM31_MDM32 PF08118.11 CDI85715.1 - 1.7 7.2 12.5 1.9 7.1 12.5 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF3292 PF11696.8 CDI85715.1 - 1.8 6.9 10.6 1.8 6.8 10.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Sin_N PF04801.13 CDI85715.1 - 1.8 7.7 28.7 1.9 7.6 28.7 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Otopetrin PF03189.13 CDI85715.1 - 1.8 7.3 11.0 2 7.2 11.0 1.1 1 0 0 1 1 1 0 Otopetrin TT_ORF1 PF02956.14 CDI85715.1 - 2 7.0 14.7 2.2 6.9 14.7 1.0 1 0 0 1 1 1 0 TT viral orf 1 eIF3_subunit PF08597.10 CDI85715.1 - 2.2 8.1 24.0 2.6 7.9 24.0 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Paf1 PF03985.13 CDI85715.1 - 2.3 7.1 28.9 3 6.8 28.9 1.1 1 0 0 1 1 1 0 Paf1 Hid1 PF12722.7 CDI85715.1 - 2.4 6.2 17.6 2.8 6.0 17.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pal1 PF08316.11 CDI85715.1 - 2.4 8.9 8.2 2.9 8.7 8.2 1.2 1 0 0 1 1 1 0 Pal1 cell morphology protein Dala_Dala_lig_N PF01820.21 CDI85715.1 - 2.6 8.6 6.7 28 5.2 6.7 2.0 1 1 0 1 1 1 0 D-ala D-ala ligase N-terminus DUF4471 PF14740.6 CDI85715.1 - 2.8 7.1 14.6 3.2 6.9 14.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) Gti1_Pac2 PF09729.9 CDI85715.1 - 2.9 7.9 17.1 3.7 7.6 17.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family RP-C_C PF11800.8 CDI85715.1 - 2.9 7.9 17.7 3.6 7.6 17.7 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region PPP4R2 PF09184.11 CDI85715.1 - 3 7.4 18.2 3.4 7.2 18.2 1.0 1 0 0 1 1 1 0 PPP4R2 HGTP_anticodon2 PF12745.7 CDI85715.1 - 3 7.3 19.1 4 6.9 19.1 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs YABBY PF04690.13 CDI85715.1 - 3.1 8.3 15.4 3.7 8.1 15.4 1.1 1 0 0 1 1 1 0 YABBY protein DUF2370 PF10176.9 CDI85715.1 - 3.2 7.3 9.4 3.6 7.2 9.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Cellulose_synt PF03552.14 CDI85715.1 - 3.4 6.0 8.2 3.4 6.0 8.2 1.0 1 0 0 1 1 1 0 Cellulose synthase HCO3_cotransp PF00955.21 CDI85715.1 - 3.8 6.2 8.8 3.7 6.3 8.8 1.1 1 0 0 1 1 1 0 HCO3- transporter family Paramyxo_ncap PF00973.19 CDI85715.1 - 3.9 6.3 13.6 4.2 6.2 13.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Het-C PF07217.11 CDI85715.1 - 4.1 5.8 11.3 4.2 5.8 11.3 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF4637 PF15470.6 CDI85715.1 - 4.1 7.1 19.0 5 6.8 19.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) PIG-S PF10510.9 CDI85715.1 - 4.2 6.1 18.2 4.1 6.1 18.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein ABC2_membrane_2 PF12679.7 CDI85715.1 - 4.4 6.5 7.2 5.2 6.3 7.2 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4337 PF14235.6 CDI85715.1 - 4.8 7.3 18.9 5.8 7.0 18.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Kei1 PF08552.11 CDI85715.1 - 4.9 7.0 14.3 6.4 6.6 14.3 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 VIR_N PF15912.5 CDI85715.1 - 5.6 6.5 14.4 6.3 6.3 14.4 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Acatn PF13000.7 CDI85715.1 - 6.9 5.0 6.0 8 4.8 6.0 1.1 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 Peptidase_S15 PF02129.18 CDI85715.1 - 7.1 6.1 14.1 8.1 5.9 14.1 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Sec62 PF03839.16 CDI85715.1 - 7.2 6.0 17.7 8.9 5.7 17.7 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 NEMP PF10225.9 CDI85715.1 - 7.3 6.2 8.8 9.8 5.8 8.8 1.3 1 0 0 1 1 1 0 NEMP family Zip PF02535.22 CDI85715.1 - 7.6 5.6 11.3 8.4 5.5 11.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter STAC2_u1 PF16664.5 CDI85715.1 - 8.5 6.9 15.7 10 6.6 15.7 1.2 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 DUF4638 PF15472.6 CDI85715.1 - 9 5.9 17.3 11 5.7 17.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) MDM10 PF12519.8 CDI85715.1 - 9.5 5.0 18.5 11 4.7 18.5 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 HemX PF04375.14 CDI85715.1 - 9.8 5.4 34.7 10 5.3 34.7 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Hamartin PF04388.12 CDI85718.1 - 0.0028 16.4 21.0 0.0032 16.2 21.0 1.2 1 0 0 1 1 1 1 Hamartin protein NPR3 PF03666.13 CDI85718.1 - 0.0045 15.8 23.1 0.0061 15.4 23.1 1.3 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 CDI85718.1 - 0.015 13.7 26.3 0.018 13.3 26.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Sin_N PF04801.13 CDI85718.1 - 0.057 12.6 38.7 0.077 12.2 38.7 1.3 1 0 0 1 1 1 0 Sin-like protein conserved region DUF2151 PF10221.9 CDI85718.1 - 0.074 11.6 15.3 0.084 11.5 15.3 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator GREB1 PF15782.5 CDI85718.1 - 0.11 9.6 23.5 0.13 9.4 23.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Apt1 PF10351.9 CDI85718.1 - 0.17 10.7 17.5 0.2 10.5 17.5 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain ASC PF00858.24 CDI85718.1 - 0.2 10.6 9.3 0.23 10.4 9.3 1.2 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Zip PF02535.22 CDI85718.1 - 0.49 9.6 17.3 0.63 9.2 17.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Otopetrin PF03189.13 CDI85718.1 - 0.53 9.1 10.6 0.69 8.7 10.6 1.4 1 0 0 1 1 1 0 Otopetrin Pkinase_fungal PF17667.1 CDI85718.1 - 0.79 8.4 12.3 0.91 8.2 12.3 1.2 1 0 0 1 1 1 0 Fungal protein kinase Hid1 PF12722.7 CDI85718.1 - 0.86 7.7 29.0 1 7.4 29.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TCP PF03634.13 CDI85718.1 - 0.92 10.1 31.6 0.17 12.5 25.3 2.2 2 0 0 2 2 2 0 TCP family transcription factor CRT10 PF08728.10 CDI85718.1 - 1.5 6.9 12.1 1.6 6.8 12.1 1.1 1 0 0 1 1 1 0 CRT10 Dicty_REP PF05086.12 CDI85718.1 - 1.7 6.5 17.4 2.1 6.3 17.4 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF572 PF04502.13 CDI85718.1 - 2.4 7.7 31.2 0.055 13.1 24.2 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF572) RR_TM4-6 PF06459.12 CDI85718.1 - 3.2 7.5 41.3 0.066 13.0 33.4 1.9 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 CDI85718.1 - 3.9 7.5 24.7 0.24 11.4 18.8 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Tmemb_14 PF03647.13 CDI85719.1 - 0.43 11.4 1.4 9.5 7.0 0.0 2.5 2 1 0 2 2 2 0 Transmembrane proteins 14C CaATP_NAI PF12515.8 CDI85720.1 - 0.0021 17.6 0.7 0.0046 16.5 0.7 1.5 1 0 0 1 1 1 1 Ca2+-ATPase N terminal autoinhibitory domain Utp14 PF04615.13 CDI85722.1 - 9.4 4.7 29.9 11 4.5 29.9 1.0 1 0 0 1 1 1 0 Utp14 protein Hydrolase_4 PF12146.8 CDI85723.1 - 3.2e-17 62.6 0.1 1.7e-12 47.1 0.1 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDI85723.1 - 3.2e-12 46.7 0.3 1.1e-08 35.0 0.3 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDI85723.1 - 1.9e-09 38.5 0.1 3.8e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.12 CDI85723.1 - 5e-08 32.0 0.0 0.0054 15.4 0.1 2.5 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) DLH PF01738.18 CDI85723.1 - 9.4e-06 25.3 0.0 3e-05 23.7 0.0 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 CDI85723.1 - 0.00021 20.8 0.0 0.00038 20.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CDI85723.1 - 0.0019 17.9 0.0 0.0061 16.2 0.0 1.7 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_5 PF12695.7 CDI85723.1 - 0.0043 16.9 0.0 0.34 10.6 0.0 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family FSH1 PF03959.13 CDI85723.1 - 0.0086 15.8 0.0 0.018 14.7 0.0 1.6 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 CDI85723.1 - 0.029 14.2 0.0 0.22 11.3 0.0 2.2 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Thioesterase PF00975.20 CDI85723.1 - 0.1 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain SPRY PF00622.28 CDI85724.1 - 0.00096 19.3 0.0 0.0019 18.3 0.0 1.4 1 0 0 1 1 1 1 SPRY domain TAFII55_N PF04658.13 CDI85725.1 - 2.1e-16 60.1 0.3 2.6e-15 56.5 0.0 2.8 3 0 0 3 3 3 1 TAFII55 protein conserved region Hydrolase_4 PF12146.8 CDI85727.1 - 2e-13 50.1 0.0 3.1e-08 33.2 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDI85727.1 - 8.7e-09 35.4 0.0 0.00021 21.0 0.0 2.8 1 1 2 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDI85727.1 - 3.7e-06 27.7 0.0 7.8e-06 26.7 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CDI85727.1 - 1e-05 25.1 0.0 2.2e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CDI85727.1 - 6.2e-05 22.7 0.0 0.00024 20.8 0.0 1.8 2 1 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.12 CDI85727.1 - 7.5e-05 21.6 0.0 0.0053 15.5 0.0 3.0 3 1 0 3 3 3 1 Acetyl xylan esterase (AXE1) DLH PF01738.18 CDI85727.1 - 0.00038 20.1 0.0 0.0019 17.8 0.0 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 CDI85727.1 - 0.00051 19.8 0.0 0.0012 18.5 0.0 1.7 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 CDI85727.1 - 0.00097 19.0 0.0 0.0039 17.0 0.0 1.9 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 CDI85727.1 - 0.0032 17.3 0.0 0.0056 16.6 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.11 CDI85727.1 - 0.018 15.0 0.0 0.12 12.2 0.0 2.0 1 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF818 PF05677.12 CDI85727.1 - 0.023 13.6 0.0 0.028 13.4 0.0 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Lipase_3 PF01764.25 CDI85727.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF2408 PF10303.9 CDI85728.1 - 0.023 15.3 0.4 0.053 14.1 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) LRR_6 PF13516.6 CDI85729.1 - 0.041 13.9 2.5 17 5.8 0.0 4.5 4 0 0 4 4 4 0 Leucine Rich repeat FAM76 PF16046.5 CDI85729.1 - 0.041 13.2 7.5 0.077 12.3 7.5 1.4 1 0 0 1 1 1 0 FAM76 protein Sec1 PF00995.23 CDI85729.1 - 0.95 8.6 2.2 1.6 7.8 2.2 1.3 1 0 0 1 1 1 0 Sec1 family HC2 PF07382.11 CDI85732.1 - 0.4 10.7 14.4 0.57 10.2 14.4 1.1 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 Pkinase PF00069.25 CDI85734.1 - 5.9e-21 75.0 0.0 8e-21 74.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI85734.1 - 2.4e-05 23.7 0.0 3.3e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Trypan_PARP PF05887.11 CDI85735.1 - 8.1 6.4 33.5 0.27 11.2 15.2 3.4 3 1 0 4 4 4 0 Procyclic acidic repetitive protein (PARP) RskA PF10099.9 CDI85736.1 - 6.9e-06 26.5 16.8 0.00091 19.6 4.0 3.2 1 1 1 2 2 2 1 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI85736.1 - 4e-05 22.7 26.1 0.0098 14.9 12.9 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI85736.1 - 0.001 19.2 35.0 0.024 14.7 17.9 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 CDI85736.1 - 0.0016 19.4 18.0 0.0024 18.8 4.3 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI85736.1 - 0.0074 15.9 18.4 0.0074 15.9 18.4 2.3 2 0 0 2 2 2 1 Spt20 family FA_desaturase PF00487.24 CDI85736.1 - 0.01 15.7 0.4 2.3 8.0 1.4 2.1 2 0 0 2 2 2 1 Fatty acid desaturase FAM176 PF14851.6 CDI85736.1 - 0.021 14.5 6.8 0.38 10.4 0.2 2.5 2 0 0 2 2 2 0 FAM176 family DUF3995 PF13160.6 CDI85736.1 - 0.039 14.3 10.9 1.1 9.6 2.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3995) Med15 PF09606.10 CDI85736.1 - 0.039 12.7 33.0 0.26 9.9 16.3 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal V_ATPase_I PF01496.19 CDI85736.1 - 0.067 11.1 4.2 0.3 8.9 0.1 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Orf78 PF06024.12 CDI85736.1 - 0.068 13.5 0.1 0.068 13.5 0.1 3.7 3 1 0 3 3 2 0 Orf78 (ac78) EPL1 PF10513.9 CDI85736.1 - 0.19 12.1 12.2 0.3 11.4 3.4 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Ribosomal_60s PF00428.19 CDI85736.1 - 0.3 11.7 18.0 1.2 9.8 0.3 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein MMR1 PF08505.10 CDI85736.1 - 0.41 10.9 13.0 1.2 9.4 5.0 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein DUF4770 PF15994.5 CDI85736.1 - 0.42 10.8 11.8 3.9 7.7 5.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) SRTM1 PF15872.5 CDI85736.1 - 0.47 10.6 4.4 5.4 7.2 1.0 2.4 2 0 0 2 2 2 0 Serine-rich and transmembrane domain-containing protein 1 CPSF100_C PF13299.6 CDI85736.1 - 0.48 10.6 9.1 3.5 7.8 4.0 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal MAGE PF01454.19 CDI85736.1 - 0.52 10.0 9.9 0.053 13.2 0.6 2.4 3 0 0 3 3 2 0 MAGE family DUF702 PF05142.12 CDI85736.1 - 0.69 10.4 17.3 1.8 9.1 2.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF702) BORG_CEP PF14957.6 CDI85736.1 - 0.78 10.9 5.9 5.6 8.2 1.5 2.3 2 0 0 2 2 2 0 Cdc42 effector Ctr PF04145.15 CDI85736.1 - 1 10.0 12.4 1.2 9.8 1.5 2.6 2 1 0 2 2 2 0 Ctr copper transporter family Neur_chan_memb PF02932.16 CDI85736.1 - 1.1 9.2 11.6 0.56 10.2 3.4 2.3 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_S49_N PF08496.10 CDI85736.1 - 1.4 9.0 7.3 17 5.5 3.0 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Plasmodium_Vir PF05795.11 CDI85736.1 - 1.6 8.1 3.1 2 7.8 0.4 1.9 2 0 0 2 2 2 0 Plasmodium vivax Vir protein RPA43_OB PF17875.1 CDI85736.1 - 1.7 9.3 10.4 2.9 8.5 3.8 2.3 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I CTNNB1_binding PF08347.11 CDI85736.1 - 1.9 8.6 10.8 8.1 6.6 5.3 2.1 2 0 0 2 2 2 0 N-terminal CTNNB1 binding DUF4578 PF15147.6 CDI85736.1 - 1.9 9.4 22.3 0.91 10.4 7.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) TERB2 PF15101.6 CDI85736.1 - 2.3 8.2 19.3 3.5 7.6 8.4 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Suf PF05843.14 CDI85736.1 - 2.5 8.0 19.2 5 7.0 4.0 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) CNDH2_M PF16869.5 CDI85736.1 - 3.2 8.4 12.1 5.4 7.7 6.1 2.3 2 0 0 2 2 2 0 PF16858 Pex14_N PF04695.13 CDI85736.1 - 3.3 8.3 28.8 0.058 14.0 9.6 2.5 3 0 0 3 3 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region eIF_4EBP PF05456.11 CDI85736.1 - 3.7 7.5 11.3 3 7.8 1.7 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) NPR1_interact PF15699.5 CDI85736.1 - 3.9 8.1 12.7 3.3 8.4 2.4 2.3 2 0 0 2 2 2 0 NPR1 interacting CTU2 PF10288.9 CDI85736.1 - 4.6 7.5 12.4 3.1 8.1 2.8 2.4 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 BRF1 PF07741.13 CDI85736.1 - 7.4 7.0 13.0 21 5.5 6.3 2.4 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF3371 PF11851.8 CDI85736.1 - 8.8 7.4 17.6 4.9 8.3 6.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) UPF0560 PF10577.9 CDI85736.1 - 10 4.5 24.3 5.2 5.4 4.7 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 TPR_4 PF07721.14 CDI85739.1 - 0.33 11.7 0.2 0.33 11.7 0.2 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Dpy-30 PF05186.13 CDI85739.1 - 2.4 7.9 9.0 0.47 10.2 0.1 3.0 4 0 0 4 4 4 0 Dpy-30 motif PIP5K PF01504.18 CDI85740.1 - 0.12 11.6 18.7 0.47 9.6 14.2 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase eIF-3_zeta PF05091.12 CDI85740.1 - 0.13 11.2 30.2 0.024 13.6 18.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM176 PF14851.6 CDI85740.1 - 0.53 9.9 19.8 0.054 13.2 8.3 2.3 2 0 0 2 2 2 0 FAM176 family Serinc PF03348.15 CDI85740.1 - 0.64 8.9 13.9 0.047 12.6 7.5 1.9 2 0 0 2 2 2 0 Serine incorporator (Serinc) Connexin PF00029.19 CDI85740.1 - 1.4 8.6 19.3 0.47 10.2 11.8 2.1 2 0 0 2 2 2 0 Connexin SpoIIP PF07454.11 CDI85740.1 - 2.3 7.6 28.4 2.8 7.3 19.8 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) TCP PF03634.13 CDI85740.1 - 4.6 7.8 28.8 0.76 10.3 18.2 2.3 2 0 0 2 2 2 0 TCP family transcription factor SID-1_RNA_chan PF13965.6 CDI85740.1 - 4.7 5.5 12.7 0.058 11.8 4.9 1.6 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DcuA_DcuB PF03605.14 CDI85740.1 - 5.6 5.7 19.4 0.078 11.9 11.0 1.8 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Afi1 PF07792.12 CDI85740.1 - 6.6 7.2 25.1 15 6.1 0.8 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking TYW3 PF02676.14 CDI85740.1 - 8 5.8 11.5 4.2 6.7 6.2 2.3 2 0 0 2 2 2 0 Methyltransferase TYW3 CDC27 PF09507.10 CDI85740.1 - 10 5.4 31.2 0.66 9.3 21.5 2.0 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Asp-B-Hydro_N PF05279.11 CDI85741.1 - 0.14 12.2 32.8 0.18 11.9 32.8 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region GREB1 PF15782.5 CDI85741.1 - 0.16 9.0 27.6 0.19 8.8 27.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIF_alpha PF05793.12 CDI85741.1 - 0.27 9.8 27.7 0.32 9.5 27.7 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Apt1 PF10351.9 CDI85741.1 - 0.41 9.4 21.3 0.62 8.9 21.3 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOBP PF15279.6 CDI85741.1 - 0.53 10.8 35.6 0.69 10.5 35.6 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein SLC12 PF03522.15 CDI85741.1 - 2.9 6.8 22.8 4.4 6.2 22.8 1.3 1 0 0 1 1 1 0 Solute carrier family 12 MMR1 PF08505.10 CDI85741.1 - 2.9 8.1 30.3 4.1 7.6 30.3 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Draxin PF15550.6 CDI85741.1 - 3.7 7.3 18.2 4.6 7.0 18.2 1.2 1 0 0 1 1 1 0 Draxin PAT1 PF09770.9 CDI85741.1 - 5.3 5.2 31.5 6.2 5.0 31.5 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF966 PF06136.13 CDI85741.1 - 8 6.1 35.5 11 5.6 35.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) EphA2_TM PF14575.6 CDI85743.1 - 2.1e-06 28.5 10.6 0.0032 18.3 3.5 2.5 2 0 0 2 2 2 2 Ephrin type-A receptor 2 transmembrane domain RskA PF10099.9 CDI85743.1 - 1.3e-05 25.5 37.1 0.00018 21.8 25.6 2.1 2 0 0 2 2 2 2 Anti-sigma-K factor rskA Jak1_Phl PF17887.1 CDI85743.1 - 0.00012 22.0 6.4 0.00012 22.0 6.4 2.1 2 0 0 2 2 2 1 Jak1 pleckstrin homology-like domain DUF2371 PF10177.9 CDI85743.1 - 0.00016 21.8 2.6 0.14 12.3 0.4 2.1 2 0 0 2 2 2 2 Uncharacterised conserved protein (DUF2371) V_ATPase_I PF01496.19 CDI85743.1 - 0.00021 19.4 16.1 0.0003 18.9 16.1 1.3 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF1772 PF08592.11 CDI85743.1 - 0.00093 19.5 3.1 0.00093 19.5 3.1 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF1772) SARAF PF06682.12 CDI85743.1 - 0.002 17.9 8.1 0.0039 16.9 8.1 1.5 1 1 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis DUF2140 PF09911.9 CDI85743.1 - 0.002 17.7 11.5 0.031 13.8 1.1 2.2 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2140) Spt20 PF12090.8 CDI85743.1 - 0.0021 17.7 7.7 0.0021 17.7 7.7 2.1 2 0 0 2 2 2 1 Spt20 family AbrB PF05145.12 CDI85743.1 - 0.0025 16.8 9.5 0.0034 16.4 9.5 1.2 1 0 0 1 1 1 1 Transition state regulatory protein AbrB Cyt_bd_oxida_II PF02322.15 CDI85743.1 - 0.0049 16.3 0.3 0.0056 16.1 0.3 1.1 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit II DUF2489 PF10675.9 CDI85743.1 - 0.0087 16.0 6.6 0.0087 16.0 6.6 3.2 2 1 1 3 3 1 1 Protein of unknown function (DUF2489) Neur_chan_memb PF02932.16 CDI85743.1 - 0.012 15.7 9.0 0.016 15.3 9.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Conotoxin PF02950.17 CDI85743.1 - 0.014 16.4 28.0 0.037 15.0 3.2 3.0 1 1 2 3 3 3 0 Conotoxin 7TM_GPCR_Sru PF10322.9 CDI85743.1 - 0.014 14.7 1.4 0.014 14.7 1.4 2.2 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sru UPF0093 PF03653.13 CDI85743.1 - 0.014 15.6 2.8 0.014 15.6 2.8 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0093) RNase_H2_suC PF08615.11 CDI85743.1 - 0.014 15.5 5.9 0.72 10.0 4.5 2.1 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Serinc PF03348.15 CDI85743.1 - 0.018 14.0 8.6 0.023 13.6 8.6 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) CNDH2_N PF06278.11 CDI85743.1 - 0.022 15.0 14.8 0.33 11.2 6.4 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal MFS_1_like PF12832.7 CDI85743.1 - 0.027 13.3 2.3 0.31 9.9 0.7 2.0 1 1 1 2 2 2 0 MFS_1 like family FA_desaturase PF00487.24 CDI85743.1 - 0.028 14.3 0.0 0.034 14.0 0.0 1.1 1 0 0 1 1 1 0 Fatty acid desaturase DUF3357 PF11837.8 CDI85743.1 - 0.032 14.7 17.9 0.37 11.3 0.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) Claudin_2 PF13903.6 CDI85743.1 - 0.038 13.7 8.9 0.019 14.7 6.7 1.5 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Lipoprotein_2 PF00921.17 CDI85743.1 - 0.039 13.5 12.9 0.052 13.1 12.9 1.2 1 0 0 1 1 1 0 Borrelia lipoprotein SpoIIP PF07454.11 CDI85743.1 - 0.046 13.2 14.6 0.15 11.5 8.9 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) TMEM51 PF15345.6 CDI85743.1 - 0.06 13.2 23.6 0.068 13.0 11.7 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 Trp_oprn_chp PF09534.10 CDI85743.1 - 0.062 13.1 21.2 0.5 10.2 21.2 1.9 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2126 PF09899.9 CDI85743.1 - 0.074 11.1 9.2 0.1 10.7 9.2 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) MMM1 PF10296.9 CDI85743.1 - 0.1 11.7 11.9 18 4.3 11.9 2.1 1 1 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 DUF3169 PF11368.8 CDI85743.1 - 0.1 12.1 9.8 0.013 15.1 2.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) DUF4381 PF14316.6 CDI85743.1 - 0.12 12.6 22.0 0.25 11.6 5.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4381) CAF1 PF04857.20 CDI85743.1 - 0.12 11.5 8.3 0.17 11.0 8.3 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease EcsB PF05975.12 CDI85743.1 - 0.13 11.1 7.8 0.22 10.4 7.8 1.4 1 1 0 1 1 1 0 Bacterial ABC transporter protein EcsB BAF1_ABF1 PF04684.13 CDI85743.1 - 0.13 11.3 16.6 0.18 10.8 16.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CRF1 PF10380.9 CDI85743.1 - 0.13 12.6 7.7 0.12 12.7 2.0 2.1 2 0 0 2 2 2 0 Transcription factor CRF1 Tetraspanin PF00335.20 CDI85743.1 - 0.13 11.9 9.8 0.22 11.2 9.8 1.4 1 1 0 1 1 1 0 Tetraspanin family RSN1_TM PF13967.6 CDI85743.1 - 0.16 11.8 0.1 0.16 11.8 0.1 2.1 1 1 1 2 2 2 0 Late exocytosis, associated with Golgi transport DUF2722 PF10846.8 CDI85743.1 - 0.16 10.9 49.7 0.17 10.8 8.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF3506 PF12014.8 CDI85743.1 - 0.17 11.9 11.1 1.1 9.2 6.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3506) FHIPEP PF00771.20 CDI85743.1 - 0.18 10.3 21.7 0.13 10.7 13.4 2.0 1 1 1 2 2 2 0 FHIPEP family Oxidored_q3 PF00499.20 CDI85743.1 - 0.18 11.5 7.1 2.6 7.8 1.0 2.1 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF4271 PF14093.6 CDI85743.1 - 0.2 11.6 4.4 0.058 13.3 1.5 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF4271) DUF898 PF05987.13 CDI85743.1 - 0.2 10.7 8.0 0.35 9.9 4.1 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) NnrU PF07298.11 CDI85743.1 - 0.22 11.0 7.9 1.3 8.5 0.7 2.1 1 1 1 2 2 2 0 NnrU protein UPF0239 PF06783.11 CDI85743.1 - 0.28 11.4 10.8 1.4 9.2 5.9 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) Cytochrom_B_N_2 PF13631.6 CDI85743.1 - 0.3 11.1 9.7 0.039 14.0 1.7 2.2 1 1 1 2 2 2 0 Cytochrome b(N-terminal)/b6/petB SID-1_RNA_chan PF13965.6 CDI85743.1 - 0.31 9.4 12.2 2.5 6.4 12.2 1.9 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Thg1C PF14413.6 CDI85743.1 - 0.35 11.0 14.9 9.6 6.4 0.0 2.2 2 0 0 2 2 2 0 Thg1 C terminal domain P5-ATPase PF12409.8 CDI85743.1 - 0.35 11.0 8.4 0.93 9.6 4.4 2.1 2 0 0 2 2 2 0 P5-type ATPase cation transporter Ribosomal_60s PF00428.19 CDI85743.1 - 0.36 11.4 14.8 0.85 10.2 14.8 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein ArsP_1 PF03773.13 CDI85743.1 - 0.38 9.9 10.1 2.4 7.2 4.1 2.1 1 1 1 2 2 2 0 Predicted permease Ndc1_Nup PF09531.10 CDI85743.1 - 0.48 9.1 16.8 0.58 8.8 16.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pet20 PF08692.10 CDI85743.1 - 0.51 11.1 7.0 4.6 8.0 3.2 2.1 2 0 0 2 2 2 0 Mitochondrial protein Pet20 EMC3_TMCO1 PF01956.16 CDI85743.1 - 0.53 10.0 14.7 0.62 9.8 9.4 2.1 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DHHC PF01529.20 CDI85743.1 - 0.57 10.3 2.9 0.56 10.3 1.0 2.0 1 1 1 2 2 2 0 DHHC palmitoyltransferase Zn_peptidase PF04228.13 CDI85743.1 - 0.62 9.5 22.9 0.54 9.6 11.7 2.1 1 1 1 2 2 2 0 Putative neutral zinc metallopeptidase O-antigen_lig PF13425.6 CDI85743.1 - 0.62 8.8 8.9 2.2 7.0 8.9 1.9 1 1 0 1 1 1 0 O-antigen ligase like membrane protein DUF1980 PF09323.10 CDI85743.1 - 0.66 9.9 16.9 1.2 9.1 16.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) DUF5385 PF17359.2 CDI85743.1 - 0.67 9.5 19.1 0.31 10.6 0.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5385) Pex24p PF06398.11 CDI85743.1 - 0.72 8.8 8.8 11 4.9 8.9 2.0 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin COPI_assoc PF08507.10 CDI85743.1 - 0.89 9.6 9.8 1.9 8.6 1.9 2.3 2 1 0 2 2 2 0 COPI associated protein Rsc14 PF08586.10 CDI85743.1 - 1.1 10.2 10.9 14 6.6 5.9 2.2 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit DUF443 PF04276.12 CDI85743.1 - 1.2 8.9 3.2 0.48 10.2 0.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF443) DUF3742 PF12553.8 CDI85743.1 - 1.5 9.0 6.7 15 5.7 0.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF3742) U3_snoRNA_assoc PF08297.11 CDI85743.1 - 1.7 9.4 13.6 8.2 7.2 0.1 2.2 2 0 0 2 2 2 0 U3 snoRNA associated YfhO PF09586.10 CDI85743.1 - 1.8 6.7 17.9 5.4 5.1 17.9 1.6 1 1 0 1 1 1 0 Bacterial membrane protein YfhO RMP PF14996.6 CDI85743.1 - 2 8.6 20.8 2.5 8.3 12.4 2.1 2 0 0 2 2 2 0 Retinal Maintenance DUF4220 PF13968.6 CDI85743.1 - 2 7.7 8.8 7.5 5.9 8.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4220) RNA_pol_Rpb2_5 PF04567.17 CDI85743.1 - 2.1 9.0 5.4 5.4 7.7 2.4 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 5 Alg14 PF08660.11 CDI85743.1 - 2.2 8.2 11.4 1.5 8.7 2.8 2.1 1 1 1 2 2 2 0 Oligosaccharide biosynthesis protein Alg14 like DcuA_DcuB PF03605.14 CDI85743.1 - 2.3 7.0 17.9 1 8.2 14.7 1.8 1 1 1 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter LMF1 PF06762.14 CDI85743.1 - 2.4 7.1 9.1 3 6.9 9.1 1.1 1 0 0 1 1 1 0 Lipase maturation factor MKT1_C PF12246.8 CDI85743.1 - 2.6 7.2 13.4 0.034 13.4 2.5 2.2 1 1 0 2 2 2 0 Temperature dependent protein affecting M2 dsRNA replication Abhydrolase_9_N PF15420.6 CDI85743.1 - 2.7 7.9 21.1 3.9 7.4 20.8 1.4 1 1 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus DUF4330 PF14221.6 CDI85743.1 - 2.8 8.1 9.4 1.5 9.0 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4330) DUF3408 PF11888.8 CDI85743.1 - 2.8 8.1 18.7 0.56 10.4 9.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) RPA43_OB PF17875.1 CDI85743.1 - 3 8.5 11.5 9.1 6.9 7.0 2.2 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I DUF3371 PF11851.8 CDI85743.1 - 3 8.9 28.8 3.4 8.8 3.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) U1snRNP70_N PF12220.8 CDI85743.1 - 3.3 8.4 18.3 0.38 11.4 7.1 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal PIG-U PF06728.13 CDI85743.1 - 3.4 6.6 12.2 0.55 9.2 2.5 2.1 1 1 1 2 2 2 0 GPI transamidase subunit PIG-U ALG3 PF05208.13 CDI85743.1 - 3.6 6.9 13.1 1.6 8.1 3.4 2.1 2 0 0 2 2 2 0 ALG3 protein ArsP_2 PF11449.8 CDI85743.1 - 4 6.5 15.0 6.5 5.9 15.0 1.3 1 1 0 1 1 1 0 Putative, 10TM heavy-metal exporter DUF1345 PF07077.11 CDI85743.1 - 4.6 6.9 17.9 0.4 10.4 9.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) CitMHS_2 PF16980.5 CDI85743.1 - 4.9 5.7 9.5 1.2 7.7 5.6 1.6 1 1 1 2 2 2 0 Putative citrate transport MPM1 PF17234.2 CDI85743.1 - 5.4 7.2 23.9 2.5 8.3 0.9 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF2992 PF11208.8 CDI85743.1 - 5.4 7.3 28.1 0.59 10.4 15.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2992) DUF4956 PF16316.5 CDI85743.1 - 6.2 6.5 11.0 7.4 6.2 2.6 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4956) DUF2298 PF10060.9 CDI85743.1 - 6.3 5.4 16.6 1.8 7.2 10.1 1.9 1 1 1 2 2 2 0 Uncharacterized membrane protein (DUF2298) Porph_ging PF09697.10 CDI85743.1 - 6.7 7.3 10.3 48 4.6 6.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) Ctr PF04145.15 CDI85743.1 - 7.2 7.2 16.4 1.2e+03 0.1 16.4 2.1 1 1 0 1 1 1 0 Ctr copper transporter family eIF_4EBP PF05456.11 CDI85743.1 - 7.2 6.6 14.8 5.7 6.9 7.5 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) OSTbeta PF15048.6 CDI85743.1 - 7.3 6.8 13.3 5 7.3 4.3 2.2 1 1 0 2 2 2 0 Organic solute transporter subunit beta protein TMEM52 PF14979.6 CDI85743.1 - 8.3 6.3 19.8 0.029 14.3 4.9 2.7 1 1 1 2 2 1 0 Transmembrane 52 Endonuc_Holl PF10107.9 CDI85743.1 - 8.3 6.2 17.9 4.3 7.2 1.3 2.1 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase OPA3 PF07047.12 CDI85743.1 - 8.5 6.2 19.3 12 5.7 1.1 2.6 1 1 1 2 2 2 0 Optic atrophy 3 protein (OPA3) TraT PF05818.12 CDI85743.1 - 8.5 6.0 31.7 0.027 14.2 16.8 2.0 1 1 1 2 2 1 0 Enterobacterial TraT complement resistance protein SelP_N PF04592.14 CDI85744.1 - 0.081 12.3 27.8 0.083 12.3 27.8 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Presenilin PF01080.17 CDI85744.1 - 0.087 11.6 20.5 0.092 11.5 20.5 1.0 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI85744.1 - 0.39 10.5 15.9 0.37 10.6 15.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PigN PF04987.14 CDI85744.1 - 0.4 9.5 5.6 0.51 9.1 5.6 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Pex14_N PF04695.13 CDI85744.1 - 0.45 11.1 27.6 0.47 11.1 27.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF5308 PF17233.2 CDI85744.1 - 0.54 10.5 15.6 0.57 10.4 15.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF4746 PF15928.5 CDI85744.1 - 0.65 9.4 10.6 0.62 9.4 10.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) V_ATPase_I PF01496.19 CDI85744.1 - 0.66 7.8 21.6 0.66 7.8 21.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family STAC2_u1 PF16664.5 CDI85744.1 - 0.72 10.3 12.5 0.86 10.1 12.5 1.1 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 DUF2098 PF09871.9 CDI85744.1 - 0.85 10.0 9.4 1.4 9.3 9.4 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) SpoIIP PF07454.11 CDI85744.1 - 0.86 9.0 17.7 0.87 9.0 17.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CLN3 PF02487.17 CDI85744.1 - 1.3 8.0 15.4 1.3 8.0 15.4 1.1 1 0 0 1 1 1 0 CLN3 protein CSG2 PF16965.5 CDI85744.1 - 1.4 7.8 12.9 1.6 7.6 12.9 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator CPSF100_C PF13299.6 CDI85744.1 - 1.7 8.8 13.5 1.7 8.8 13.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal HNOBA PF07701.14 CDI85744.1 - 1.8 7.9 18.7 2.4 7.6 18.7 1.2 1 0 0 1 1 1 0 Heme NO binding associated DUF2072 PF09845.9 CDI85744.1 - 2 8.7 12.9 2 8.7 12.9 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein Connexin PF00029.19 CDI85744.1 - 2.3 7.9 17.4 2.5 7.8 17.4 1.1 1 0 0 1 1 1 0 Connexin Afi1 PF07792.12 CDI85744.1 - 2.3 8.7 21.3 2.8 8.4 21.3 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Gti1_Pac2 PF09729.9 CDI85744.1 - 2.7 8.1 17.5 2.8 8.0 17.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family eIF-3_zeta PF05091.12 CDI85744.1 - 2.8 6.8 25.5 3 6.7 25.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFB6 PF17110.5 CDI85744.1 - 3.1 7.5 11.5 3.9 7.2 11.5 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH SID-1_RNA_chan PF13965.6 CDI85744.1 - 3.3 6.0 9.9 3.3 6.0 9.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 CDI85744.1 - 3.4 6.6 18.8 3.2 6.7 18.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DDHD PF02862.17 CDI85744.1 - 3.5 7.7 17.4 3.7 7.7 17.4 1.1 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 CDI85744.1 - 4.7 7.2 16.6 4.7 7.2 16.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CNDH2_M PF16869.5 CDI85744.1 - 4.9 7.8 15.4 9.3 6.9 15.4 1.4 1 1 0 1 1 1 0 PF16858 DUF2828 PF11443.8 CDI85744.1 - 5.6 4.9 21.4 6.3 4.8 21.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) FAM176 PF14851.6 CDI85744.1 - 6.6 6.4 11.8 8.2 6.1 11.8 1.2 1 0 0 1 1 1 0 FAM176 family Serinc PF03348.15 CDI85744.1 - 6.9 5.5 11.6 7 5.5 11.6 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) FAM60A PF15396.6 CDI85744.1 - 7.5 6.5 16.5 7.6 6.5 16.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A PAT1 PF09770.9 CDI85744.1 - 8 4.6 34.4 7.8 4.6 34.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Herpes_glycop PF01528.16 CDI85744.1 - 8 5.2 7.4 9 5.0 7.4 1.2 1 0 0 1 1 1 0 Herpesvirus glycoprotein M AIF_C PF14721.6 CDI85744.1 - 8.2 6.8 15.7 10 6.5 15.7 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TetR_C_23 PF17931.1 CDI85744.1 - 8.5 6.5 11.4 9.7 6.3 11.4 1.1 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF3881 PF12997.7 CDI85745.1 - 0.059 12.6 0.0 0.059 12.6 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3881) RskA PF10099.9 CDI85745.1 - 0.12 12.6 31.5 0.14 12.5 15.3 3.1 2 1 1 3 3 3 0 Anti-sigma-K factor rskA DUF276 PF03434.13 CDI85745.1 - 1.8 7.6 4.5 0.18 11.0 0.2 1.5 2 0 0 2 2 2 0 DUF276 Tim54 PF11711.8 CDI85746.1 - 1.1 7.9 19.8 1.2 7.9 19.8 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 MDM10 PF12519.8 CDI85746.1 - 2.9 6.6 20.9 2.9 6.7 20.9 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CPSF100_C PF13299.6 CDI85746.1 - 3 8.0 19.7 3.4 7.8 19.7 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 CDI85746.1 - 3.3 6.6 17.3 3.4 6.6 17.3 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3807 PF12720.7 CDI85746.1 - 3.3 8.0 32.1 3.7 7.8 32.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF5308 PF17233.2 CDI85746.1 - 3.3 7.9 19.0 4.2 7.6 19.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Connexin PF00029.19 CDI85746.1 - 3.3 7.4 19.4 3.4 7.3 19.4 1.1 1 0 0 1 1 1 0 Connexin Gti1_Pac2 PF09729.9 CDI85746.1 - 3.7 7.6 21.0 4 7.5 21.0 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family CobT PF06213.12 CDI85746.1 - 3.9 6.8 33.3 4.4 6.6 33.3 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RPN2_C PF18004.1 CDI85746.1 - 5.3 6.9 22.5 6.2 6.7 22.5 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain FAM176 PF14851.6 CDI85746.1 - 6.1 6.5 15.2 9.1 5.9 15.2 1.3 1 0 0 1 1 1 0 FAM176 family PIP5K PF01504.18 CDI85746.1 - 6.2 6.0 20.5 6.5 5.9 20.5 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2561 PF10812.8 CDI85746.1 - 6.6 6.7 5.2 7.6 6.5 5.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) DREPP PF05558.12 CDI85746.1 - 6.6 6.6 6.9 7 6.5 6.9 1.0 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide DUF2058 PF09831.9 CDI85746.1 - 8.8 6.4 38.5 9.5 6.3 38.5 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) DUF2828 PF11443.8 CDI85746.1 - 9.3 4.2 25.1 11 4.0 25.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Spt20 PF12090.8 CDI85747.1 - 0.00036 20.2 15.2 0.00037 20.2 15.2 1.1 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 CDI85747.1 - 0.0053 16.8 12.9 0.0053 16.8 12.9 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI85747.1 - 0.0065 16.8 2.1 0.0079 16.5 2.1 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF533 PF04391.12 CDI85747.1 - 0.013 15.0 3.0 0.015 14.9 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Rpp20 PF12328.8 CDI85747.1 - 0.014 15.3 0.6 0.016 15.2 0.6 1.1 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P FHIPEP PF00771.20 CDI85747.1 - 0.016 13.7 1.6 0.015 13.8 1.6 1.0 1 0 0 1 1 1 0 FHIPEP family PSCyt3 PF07627.11 CDI85747.1 - 0.023 15.0 1.0 0.027 14.8 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1588) DUF4770 PF15994.5 CDI85747.1 - 0.026 14.8 4.5 0.034 14.4 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF3464 PF11947.8 CDI85747.1 - 0.032 14.0 0.3 0.032 14.0 0.3 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 SARAF PF06682.12 CDI85747.1 - 0.033 13.9 4.5 0.037 13.7 4.5 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis UPF0560 PF10577.9 CDI85747.1 - 0.045 12.3 4.2 0.04 12.4 4.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 CrgA PF06781.12 CDI85747.1 - 0.077 13.1 1.2 0.14 12.2 1.2 1.4 1 0 0 1 1 1 0 Cell division protein CrgA TMEM51 PF15345.6 CDI85747.1 - 0.14 12.0 8.7 0.068 13.0 6.8 1.4 1 1 0 1 1 1 0 Transmembrane protein 51 Suf PF05843.14 CDI85747.1 - 0.2 11.6 5.9 0.19 11.7 5.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2722 PF10846.8 CDI85747.1 - 0.26 10.2 18.3 0.33 9.9 18.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Orf78 PF06024.12 CDI85747.1 - 0.26 11.6 5.6 0.099 13.0 2.0 1.9 2 0 0 2 2 2 0 Orf78 (ac78) NapE PF06796.11 CDI85747.1 - 0.42 10.2 2.6 0.66 9.5 0.8 2.2 2 1 0 2 2 2 0 Periplasmic nitrate reductase protein NapE Nuc_deoxyri_tr2 PF15891.5 CDI85747.1 - 0.78 10.1 5.6 2.3 8.6 3.7 1.9 1 1 1 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like Pex14_N PF04695.13 CDI85747.1 - 0.79 10.4 10.6 1.1 9.9 10.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Kei1 PF08552.11 CDI85747.1 - 2.4 8.0 5.8 2 8.3 3.6 1.6 1 1 1 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Roughex PF06020.11 CDI85747.1 - 5.5 6.0 11.1 6.6 5.7 11.1 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Presenilin PF01080.17 CDI85748.1 - 4.4e-05 22.4 42.2 0.00016 20.6 27.7 2.5 2 0 0 2 2 2 2 Presenilin FRQ PF09421.10 CDI85748.1 - 0.00074 17.7 18.1 0.00074 17.7 18.1 3.6 4 1 0 5 5 5 1 Frequency clock protein Macoilin PF09726.9 CDI85748.1 - 0.0031 16.2 21.1 0.0031 16.2 21.1 3.5 3 1 0 4 4 4 1 Macoilin family SR-25 PF10500.9 CDI85748.1 - 0.0047 16.6 0.9 0.0047 16.6 0.9 6.0 5 1 1 6 6 6 1 Nuclear RNA-splicing-associated protein DNA_pol_phi PF04931.13 CDI85749.1 - 0.00071 17.8 10.0 0.00071 17.8 10.0 5.0 4 1 1 5 5 5 1 DNA polymerase phi BUD22 PF09073.10 CDI85749.1 - 0.0015 17.9 30.5 0.0015 17.9 30.5 4.1 2 1 0 3 3 3 1 BUD22 PNISR PF15996.5 CDI85750.1 - 0.00035 20.9 4.3 0.00044 20.6 4.3 1.2 1 0 0 1 1 1 1 Arginine/serine-rich protein PNISR TFIIA PF03153.13 CDI85750.1 - 0.00094 19.3 18.3 0.0012 19.0 18.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit MAP65_ASE1 PF03999.12 CDI85750.1 - 0.039 12.6 24.2 0.046 12.4 24.2 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) SPX PF03105.19 CDI85750.1 - 0.11 12.4 26.3 0.14 12.0 26.3 1.1 1 0 0 1 1 1 0 SPX domain Roughex PF06020.11 CDI85750.1 - 0.23 10.6 5.9 0.28 10.3 5.9 1.2 1 0 0 1 1 1 0 Drosophila roughex protein PAT1 PF09770.9 CDI85750.1 - 1.5 7.0 15.2 1.7 6.8 15.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4175 PF13779.6 CDI85750.1 - 5.2 4.8 16.0 6.7 4.5 16.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ALMT PF11744.8 CDI85750.1 - 7.8 5.2 14.0 11 4.7 14.0 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DctQ PF04290.12 CDI85751.1 - 0.1 12.5 0.9 0.17 11.8 0.9 1.3 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component GBP PF02263.19 CDI85752.1 - 2.1e-16 60.0 0.1 1.7e-15 57.0 0.1 2.3 1 1 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 CDI85752.1 - 6.6e-08 32.3 20.6 5.5e-07 29.3 20.6 1.9 1 1 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Dynamin_N PF00350.23 CDI85752.1 - 3.7 7.6 5.3 3.3 7.7 0.1 2.5 2 0 0 2 2 2 0 Dynamin family DUF4207 PF13904.6 CDI85754.1 - 0.00013 21.8 18.2 0.00013 21.8 18.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4207) CDC27 PF09507.10 CDI85754.1 - 0.1 12.0 30.5 0.13 11.6 30.5 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 GAGA_bind PF06217.12 CDI85754.1 - 0.62 10.3 18.5 0.76 10.0 18.5 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family BRF1 PF07741.13 CDI85754.1 - 0.85 10.0 21.4 3 8.2 5.4 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF2052 PF09747.9 CDI85754.1 - 0.85 9.7 25.4 1.2 9.2 25.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PBP_N PF17093.5 CDI85754.1 - 0.93 9.7 2.4 1.7 8.9 2.4 1.5 1 0 0 1 1 1 0 Penicillin-binding protein N-terminus MecA PF05389.12 CDI85754.1 - 1.1 8.8 21.8 0.51 9.9 5.5 2.1 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) ALMT PF11744.8 CDI85754.1 - 1.1 8.0 18.6 1.6 7.5 18.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 CDI85754.1 - 1.2 8.1 24.8 1.6 7.7 24.8 1.3 1 0 0 1 1 1 0 Solute carrier family 12 ODV-E18 PF10717.9 CDI85754.1 - 1.9 8.4 5.2 3.2 7.7 5.2 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 EIIBC-GUT_N PF03612.14 CDI85754.1 - 2 8.1 26.7 3.3 7.4 8.8 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Thg1C PF14413.6 CDI85754.1 - 2.1 8.5 19.5 0.91 9.7 3.3 2.2 2 0 0 2 2 2 0 Thg1 C terminal domain VIR_N PF15912.5 CDI85754.1 - 2.6 7.6 17.2 3.6 7.1 17.2 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal XRN_M PF17846.1 CDI85754.1 - 3.2 6.6 18.9 4 6.3 18.9 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Methyltransf_12 PF08242.12 CDI85754.1 - 3.5 8.4 9.4 2 9.2 1.5 2.2 2 0 0 2 2 2 0 Methyltransferase domain RLL PF10036.9 CDI85754.1 - 4.2 7.1 27.3 0.47 10.2 7.3 2.1 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein Caldesmon PF02029.15 CDI85754.1 - 5.2 5.7 31.3 6.5 5.4 31.3 1.0 1 0 0 1 1 1 0 Caldesmon DUF1682 PF07946.14 CDI85754.1 - 7.1 5.7 17.6 1.3 8.2 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) HemX PF04375.14 CDI85754.1 - 7.3 5.8 41.2 10 5.3 41.2 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase ARF7EP_C PF14949.6 CDI85754.1 - 7.6 7.2 23.0 4.1 8.0 7.3 2.2 2 0 0 2 2 2 0 ARF7 effector protein C-terminus Caldesmon PF02029.15 CDI85755.1 - 0.022 13.5 25.6 0.024 13.4 25.6 1.1 1 0 0 1 1 1 0 Caldesmon Mitofilin PF09731.9 CDI85755.1 - 0.12 11.2 28.6 0.17 10.7 28.6 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Exonuc_VII_L PF02601.15 CDI85755.1 - 0.2 11.2 28.1 0.26 10.8 28.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit GREB1 PF15782.5 CDI85755.1 - 0.64 7.1 47.2 0.75 6.8 47.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AF-4 PF05110.13 CDI85755.1 - 0.89 7.6 56.8 1.2 7.2 56.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF936 PF06075.12 CDI85755.1 - 4 6.2 34.5 7.2 5.4 34.5 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Med15 PF09606.10 CDI85755.1 - 4.2 5.9 79.8 5.2 5.6 79.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RIFIN PF02009.16 CDI85755.1 - 7.1 6.4 23.3 10 5.9 23.3 1.2 1 0 0 1 1 1 0 Rifin Spt20 PF12090.8 CDI85756.1 - 0.0025 17.5 25.7 0.0028 17.3 25.7 1.2 1 0 0 1 1 1 1 Spt20 family DUF4834 PF16118.5 CDI85756.1 - 0.0049 17.8 8.0 0.0052 17.7 8.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) eIF-3_zeta PF05091.12 CDI85756.1 - 0.025 13.6 11.9 0.024 13.7 11.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI85756.1 - 0.03 13.1 7.9 0.028 13.2 7.9 1.1 1 0 0 1 1 1 0 Presenilin Afi1 PF07792.12 CDI85756.1 - 0.04 14.4 6.2 0.047 14.2 6.2 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DDHD PF02862.17 CDI85756.1 - 0.042 14.0 5.4 0.039 14.1 5.4 1.0 1 0 0 1 1 1 0 DDHD domain BSMAP PF12280.8 CDI85756.1 - 0.058 13.6 8.1 0.066 13.4 8.1 1.0 1 0 0 1 1 1 0 Brain specific membrane anchored protein DUF4820 PF16091.5 CDI85756.1 - 0.077 12.4 5.3 0.093 12.1 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) SID-1_RNA_chan PF13965.6 CDI85756.1 - 0.085 11.3 1.5 0.098 11.1 1.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TERB2 PF15101.6 CDI85756.1 - 0.13 12.2 12.3 0.13 12.3 12.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF702 PF05142.12 CDI85756.1 - 0.19 12.2 10.3 0.25 11.8 10.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) EIIBC-GUT_N PF03612.14 CDI85756.1 - 0.19 11.4 6.0 0.21 11.3 6.0 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CLN3 PF02487.17 CDI85756.1 - 0.21 10.6 4.1 0.19 10.7 4.1 1.1 1 0 0 1 1 1 0 CLN3 protein EOS1 PF12326.8 CDI85756.1 - 0.27 11.2 2.4 0.26 11.2 2.4 1.1 1 0 0 1 1 1 0 N-glycosylation protein Serinc PF03348.15 CDI85756.1 - 0.33 9.8 3.9 0.36 9.7 3.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Folate_carrier PF01770.18 CDI85756.1 - 0.38 9.4 2.6 0.39 9.4 2.6 1.1 1 0 0 1 1 1 0 Reduced folate carrier Ctr PF04145.15 CDI85756.1 - 0.5 11.0 2.0 0.48 11.0 2.0 1.2 1 0 0 1 1 1 0 Ctr copper transporter family TFIIA PF03153.13 CDI85756.1 - 0.54 10.2 27.2 0.51 10.3 27.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zip PF02535.22 CDI85756.1 - 0.87 8.7 3.0 0.78 8.9 3.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Kei1 PF08552.11 CDI85756.1 - 0.89 9.4 3.4 0.94 9.3 3.4 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 UPF0239 PF06783.11 CDI85756.1 - 1.1 9.5 7.4 1.7 8.9 7.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) CSG2 PF16965.5 CDI85756.1 - 1.2 8.0 2.3 1.1 8.1 2.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Plasmodium_Vir PF05795.11 CDI85756.1 - 1.5 8.1 6.0 1.6 8.1 6.0 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Neur_chan_memb PF02932.16 CDI85756.1 - 1.7 8.7 6.4 1.6 8.8 6.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Band_3_cyto PF07565.13 CDI85756.1 - 2.4 7.9 9.2 2.4 7.9 9.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Pex14_N PF04695.13 CDI85756.1 - 3.1 8.4 16.2 3.5 8.2 16.2 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM176 PF14851.6 CDI85756.1 - 3.3 7.4 8.4 4.3 7.0 8.4 1.2 1 0 0 1 1 1 0 FAM176 family DUF4407 PF14362.6 CDI85756.1 - 3.7 6.8 11.3 3.8 6.8 11.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SprA-related PF12118.8 CDI85756.1 - 4.2 6.4 22.7 4.3 6.4 22.7 1.2 1 0 0 1 1 1 0 SprA-related family DUF2828 PF11443.8 CDI85756.1 - 7.1 4.6 12.1 7.8 4.5 12.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) AIF_C PF14721.6 CDI85756.1 - 7.2 7.0 9.5 8.6 6.7 9.5 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RR_TM4-6 PF06459.12 CDI85756.1 - 7.4 6.3 12.6 8.3 6.1 12.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Upf2 PF04050.14 CDI85759.1 - 0.0002 22.1 20.5 0.0002 22.1 20.5 4.6 2 2 2 4 4 4 2 Up-frameshift suppressor 2 Shadoo PF14999.6 CDI85759.1 - 0.0033 17.5 5.4 0.28 11.3 1.3 2.3 2 0 0 2 2 2 2 Shadow of prion protein, neuroprotective LRR_8 PF13855.6 CDI85760.1 - 0.00067 19.4 37.2 0.026 14.3 7.9 4.5 3 1 0 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 CDI85760.1 - 1.2 10.0 9.2 1.6e+02 3.5 1.1 5.4 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_4 PF12799.7 CDI85760.1 - 9.7 6.8 44.5 0.038 14.4 3.8 5.8 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) Asp-B-Hydro_N PF05279.11 CDI85761.1 - 0.059 13.4 20.5 0.082 13.0 20.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region PAT1 PF09770.9 CDI85761.1 - 0.096 10.9 43.4 0.11 10.8 43.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CCSAP PF15748.5 CDI85761.1 - 0.099 12.8 29.5 0.12 12.5 29.5 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated ADD_DNMT3 PF17980.1 CDI85761.1 - 0.11 12.5 0.1 0.25 11.4 0.1 1.6 1 0 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 Lin-8 PF03353.15 CDI85761.1 - 0.22 11.1 27.6 0.26 10.8 27.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 CDI85761.1 - 0.24 9.7 21.8 0.27 9.5 21.8 1.0 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI85761.1 - 0.57 9.1 25.1 0.65 9.0 25.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 BORG_CEP PF14957.6 CDI85761.1 - 0.68 11.1 16.4 1 10.6 16.4 1.3 1 0 0 1 1 1 0 Cdc42 effector Exonuc_VII_L PF02601.15 CDI85761.1 - 0.82 9.2 25.2 0.92 9.0 25.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4746 PF15928.5 CDI85761.1 - 0.91 8.9 16.7 1.1 8.6 16.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) GREB1 PF15782.5 CDI85761.1 - 1 6.4 23.0 1.1 6.3 23.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 CDI85761.1 - 1.9 6.5 25.8 2.1 6.4 25.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.12 CDI85761.1 - 2.4 7.9 27.8 2.9 7.6 27.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI85761.1 - 2.7 6.7 31.5 3.2 6.4 31.5 1.1 1 0 0 1 1 1 0 Presenilin Endostatin PF06482.11 CDI85761.1 - 3 7.2 22.4 3.9 6.9 22.4 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF2052 PF09747.9 CDI85761.1 - 3.4 7.7 28.3 4.2 7.5 28.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) LAP1C PF05609.12 CDI85761.1 - 4.8 6.2 24.8 5.4 6.0 24.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Sin_N PF04801.13 CDI85761.1 - 7.6 5.6 35.7 9.1 5.4 35.7 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region DUF2151 PF10221.9 CDI85761.1 - 8.1 4.9 15.8 9.6 4.7 15.8 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Peptidase_S64 PF08192.11 CDI85761.1 - 9.5 4.6 19.4 13 4.2 19.4 1.2 1 0 0 1 1 1 0 Peptidase family S64 Mucin PF01456.17 CDI85762.1 - 0.012 15.6 10.9 0.012 15.6 10.9 3.6 4 0 0 4 4 4 0 Mucin-like glycoprotein S1 PF00575.23 CDI85763.1 - 0.00026 21.2 0.0 0.00049 20.4 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain CCDC24 PF15669.5 CDI85763.1 - 9.8 6.0 11.6 2 8.2 6.4 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family NPAT_C PF15712.5 CDI85764.1 - 5.3 5.6 22.1 5.6 5.5 22.1 1.0 1 0 0 1 1 1 0 NPAT C terminus BAF1_ABF1 PF04684.13 CDI85764.1 - 6.4 5.7 23.2 6.9 5.6 23.2 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor NST1 PF13945.6 CDI85764.1 - 6.7 6.8 26.4 7.2 6.7 26.4 1.0 1 0 0 1 1 1 0 Salt tolerance down-regulator SR-25 PF10500.9 CDI85765.1 - 1.9e-07 31.0 19.9 2.5e-07 30.5 19.9 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein TCP PF03634.13 CDI85765.1 - 0.00046 20.8 17.1 0.00051 20.6 17.1 1.0 1 0 0 1 1 1 1 TCP family transcription factor TMEM51 PF15345.6 CDI85765.1 - 0.015 15.1 14.9 0.02 14.8 14.9 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 eIF-3_zeta PF05091.12 CDI85765.1 - 0.08 11.9 16.5 0.077 12.0 16.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI85765.1 - 0.14 10.9 20.6 0.15 10.8 20.6 1.0 1 0 0 1 1 1 0 Presenilin Velvet PF11754.8 CDI85765.1 - 0.38 10.7 20.9 0.43 10.5 20.9 1.0 1 0 0 1 1 1 0 Velvet factor CCSAP PF15748.5 CDI85765.1 - 0.4 10.8 22.5 0.5 10.5 22.5 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated V_ATPase_I PF01496.19 CDI85765.1 - 0.49 8.3 11.1 0.49 8.2 11.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Suf PF05843.14 CDI85765.1 - 0.52 10.2 22.6 0.58 10.1 22.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4175 PF13779.6 CDI85765.1 - 0.74 7.7 30.1 0.66 7.8 30.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) EOS1 PF12326.8 CDI85765.1 - 0.85 9.5 10.2 1.1 9.2 10.2 1.2 1 0 0 1 1 1 0 N-glycosylation protein DUF4050 PF13259.6 CDI85765.1 - 0.97 9.7 15.5 1.3 9.3 15.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) FAM199X PF15814.5 CDI85765.1 - 1.4 7.9 22.0 1.7 7.6 22.0 1.0 1 0 0 1 1 1 0 Protein family FAM199X SLC12 PF03522.15 CDI85765.1 - 2.6 7.0 13.8 3 6.8 13.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Serinc PF03348.15 CDI85765.1 - 3.2 6.6 8.6 3.7 6.4 8.6 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) RAP1 PF07218.11 CDI85765.1 - 3.6 5.7 9.9 2.8 6.1 9.9 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Cellulose_synt PF03552.14 CDI85765.1 - 4.2 5.7 6.2 4.7 5.6 6.2 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF913 PF06025.12 CDI85765.1 - 4.3 6.2 12.6 5.8 5.8 12.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Eapp_C PF10238.9 CDI85765.1 - 8 6.5 21.1 24 5.0 0.1 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein SOBP PF15279.6 CDI85767.1 - 0.0049 17.5 38.7 0.069 13.8 19.9 2.3 2 0 0 2 2 2 2 Sine oculis-binding protein PNISR PF15996.5 CDI85767.1 - 0.014 15.7 9.8 0.014 15.7 9.8 4.0 2 1 0 3 3 3 0 Arginine/serine-rich protein PNISR TFIIA PF03153.13 CDI85767.1 - 0.089 12.8 59.8 0.095 12.7 24.6 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Mem_trans PF03547.18 CDI85767.1 - 0.13 10.6 0.0 0.13 10.6 0.0 1.5 2 0 0 2 2 2 0 Membrane transport protein Citrate_synt PF00285.21 CDI85767.1 - 0.36 9.8 4.1 0.69 8.9 4.1 1.4 1 0 0 1 1 1 0 Citrate synthase, C-terminal domain SprA-related PF12118.8 CDI85767.1 - 1.9 7.5 57.0 0.03 13.5 20.5 2.4 2 0 0 2 2 2 0 SprA-related family Spt20 PF12090.8 CDI85767.1 - 6 6.4 67.1 0.12 12.0 18.7 3.0 3 0 0 3 3 3 0 Spt20 family RskA PF10099.9 CDI85768.1 - 0.005 17.1 5.6 0.005 17.1 5.6 5.0 1 1 4 5 5 5 2 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI85768.1 - 0.0066 16.5 6.3 0.0066 16.5 6.3 6.8 3 2 2 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 Ycf1 PF05758.12 CDI85768.1 - 0.28 9.0 9.6 0.17 9.7 5.3 2.0 2 0 0 2 2 2 0 Ycf1 Utp14 PF04615.13 CDI85768.1 - 0.95 8.0 45.5 1.2 7.6 45.5 1.1 1 0 0 1 1 1 0 Utp14 protein Spc7 PF08317.11 CDI85769.1 - 0.67 8.8 49.6 0.018 14.0 28.0 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Clat_adaptor_s PF01217.20 CDI85770.1 - 0.032 14.2 0.1 0.051 13.5 0.1 1.3 1 0 0 1 1 1 0 Clathrin adaptor complex small chain DUF4834 PF16118.5 CDI85771.1 - 0.00056 20.8 10.9 0.023 15.7 1.5 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) ANAPC_CDC26 PF10471.9 CDI85771.1 - 0.0028 18.5 11.2 0.0028 18.5 11.2 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex APC subunit CDC26 RskA PF10099.9 CDI85771.1 - 0.0031 17.8 31.0 0.021 15.1 19.8 2.1 1 1 1 2 2 2 2 Anti-sigma-K factor rskA PIP5K PF01504.18 CDI85771.1 - 0.005 16.1 3.6 0.006 15.9 3.6 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase EphA2_TM PF14575.6 CDI85771.1 - 0.013 16.4 0.7 0.013 16.4 0.7 2.4 2 1 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Conotoxin PF02950.17 CDI85771.1 - 0.023 15.7 4.5 0.023 15.7 4.5 2.4 2 1 0 2 2 2 0 Conotoxin DUF3290 PF11694.8 CDI85771.1 - 0.034 14.1 5.2 0.034 14.1 5.2 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF3290) FAM209 PF15206.6 CDI85771.1 - 0.086 12.6 0.1 0.086 12.6 0.1 1.7 2 0 0 2 2 2 0 FAM209 family DUF4064 PF13273.6 CDI85771.1 - 0.096 13.0 0.8 0.096 13.0 0.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) WBP-1 PF11669.8 CDI85771.1 - 0.11 13.1 0.6 0.11 13.1 0.6 2.2 2 0 0 2 2 2 0 WW domain-binding protein 1 DUF5327 PF17261.2 CDI85771.1 - 0.15 12.9 20.0 1.4 9.7 6.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5327) Peptidase_S49_N PF08496.10 CDI85771.1 - 0.16 12.0 6.3 1.6 8.8 0.6 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal TMEM51 PF15345.6 CDI85771.1 - 0.18 11.6 15.4 0.13 12.1 5.0 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 GRP PF07172.11 CDI85771.1 - 0.28 11.9 0.3 0.28 11.9 0.3 2.1 2 0 0 2 2 2 0 Glycine rich protein family Rxt3 PF08642.10 CDI85771.1 - 0.3 11.9 7.0 0.99 10.2 0.9 2.1 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 Presenilin PF01080.17 CDI85771.1 - 0.39 9.4 12.8 0.54 9.0 12.8 1.2 1 0 0 1 1 1 0 Presenilin DUF2722 PF10846.8 CDI85771.1 - 0.58 9.0 38.7 0.043 12.8 13.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF4770 PF15994.5 CDI85771.1 - 0.65 10.2 11.6 0.93 9.7 2.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) FAM91_C PF14648.6 CDI85771.1 - 1.8 7.3 13.2 0.036 12.9 0.7 1.9 1 1 1 2 2 2 0 FAM91 C-terminus MRI PF15325.6 CDI85771.1 - 2.3 9.4 6.7 0.68 11.0 0.8 2.0 2 0 0 2 2 2 0 Modulator of retrovirus infection DUF2140 PF09911.9 CDI85771.1 - 3.4 7.2 8.8 0.34 10.4 1.1 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) dsDNA_bind PF01984.20 CDI85771.1 - 3.5 7.9 30.6 0.065 13.5 8.0 2.3 2 0 0 2 2 2 0 Double-stranded DNA-binding domain Spore_coat_CotO PF14153.6 CDI85771.1 - 7 6.5 23.2 1.6 8.7 5.4 2.1 2 0 0 2 2 2 0 Spore coat protein CotO MAGP PF05507.11 CDI85771.1 - 7.1 7.0 8.0 0.077 13.4 0.6 1.5 2 0 0 2 2 1 0 Microfibril-associated glycoprotein (MAGP) PigN PF04987.14 CDI85771.1 - 8.8 5.1 7.6 2.3 7.0 1.6 2.0 2 0 0 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) Rpp20 PF12328.8 CDI85771.1 - 9.6 6.2 12.3 7.8 6.5 1.3 2.1 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P RskA PF10099.9 CDI85772.1 - 3.2e-06 27.6 3.9 5.8e-06 26.7 4.0 1.3 1 1 0 1 1 1 1 Anti-sigma-K factor rskA BAF1_ABF1 PF04684.13 CDI85772.1 - 0.0061 15.7 12.8 0.0067 15.5 12.8 1.1 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor FAM199X PF15814.5 CDI85772.1 - 0.013 14.6 16.5 0.016 14.3 16.5 1.1 1 0 0 1 1 1 0 Protein family FAM199X Peptidase_S64 PF08192.11 CDI85772.1 - 0.017 13.6 14.9 0.02 13.4 14.9 1.0 1 0 0 1 1 1 0 Peptidase family S64 eIF3_subunit PF08597.10 CDI85772.1 - 0.019 14.9 7.8 0.031 14.2 7.8 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit FHIPEP PF00771.20 CDI85772.1 - 0.13 10.7 0.8 0.18 10.2 0.8 1.2 1 0 0 1 1 1 0 FHIPEP family Mitofilin PF09731.9 CDI85772.1 - 0.15 10.9 15.3 0.17 10.7 15.3 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein TRAP_alpha PF03896.16 CDI85772.1 - 0.16 11.1 4.3 0.24 10.6 4.3 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2124 PF09897.9 CDI85772.1 - 0.18 11.7 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2124) DUF3824 PF12868.7 CDI85772.1 - 0.21 12.2 15.1 0.18 12.5 10.4 2.2 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Lin-8 PF03353.15 CDI85772.1 - 0.21 11.1 17.9 0.23 11.0 3.8 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist MAP70 PF07058.11 CDI85772.1 - 0.25 10.1 10.7 0.31 9.7 10.7 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 PNISR PF15996.5 CDI85772.1 - 0.33 11.2 18.9 0.5 10.6 18.9 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR SR-25 PF10500.9 CDI85772.1 - 0.44 10.1 31.9 2.2e+02 1.3 31.9 2.1 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 CDI85772.1 - 0.49 9.1 15.3 0.75 8.5 15.3 1.3 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 CDI85772.1 - 0.59 8.7 12.7 0.7 8.5 12.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SPX PF03105.19 CDI85772.1 - 0.65 9.8 19.0 0.84 9.5 19.0 1.1 1 0 0 1 1 1 0 SPX domain INSIG PF07281.12 CDI85772.1 - 0.66 9.6 2.6 1.2 8.7 2.6 1.6 1 1 0 1 1 1 0 Insulin-induced protein (INSIG) DUF966 PF06136.13 CDI85772.1 - 0.77 9.4 18.6 0.9 9.2 18.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) SLC12 PF03522.15 CDI85772.1 - 1.4 7.9 10.4 1.8 7.5 10.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 PPP4R2 PF09184.11 CDI85772.1 - 1.5 8.3 17.1 2 7.9 17.1 1.1 1 0 0 1 1 1 0 PPP4R2 BSP_II PF05432.11 CDI85772.1 - 1.9 8.1 15.1 2.5 7.7 15.1 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Lipoprotein_2 PF00921.17 CDI85772.1 - 2.1 7.8 11.5 2.9 7.4 11.5 1.2 1 0 0 1 1 1 0 Borrelia lipoprotein SRP-alpha_N PF04086.13 CDI85772.1 - 2.2 8.1 13.2 3.1 7.6 13.2 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal MPM1 PF17234.2 CDI85772.1 - 4 7.7 12.9 2.3 8.4 2.9 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 MAT1 PF06391.13 CDI85772.1 - 5.4 6.8 15.4 0.42 10.4 6.7 2.1 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Raftlin PF15250.6 CDI85772.1 - 5.7 5.6 13.7 6.7 5.3 13.7 1.2 1 0 0 1 1 1 0 Raftlin Pap_E4 PF02711.14 CDI85772.1 - 7.2 7.6 14.6 8.4 7.4 6.4 2.3 2 0 0 2 2 2 0 E4 protein Serinc PF03348.15 CDI85772.1 - 7.7 5.3 7.2 9.8 5.0 7.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Herpes_pp85 PF04637.12 CDI85772.1 - 9.7 4.5 11.1 15 3.9 11.1 1.3 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF533 PF04391.12 CDI85772.1 - 10 5.7 22.5 10 5.7 1.5 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF533) SNF2_N PF00176.23 CDI85773.1 - 1.3e-35 122.8 0.0 6e-31 107.4 0.0 3.5 4 0 0 4 4 4 2 SNF2 family N-terminal domain zf-RING_UBOX PF13445.6 CDI85773.1 - 1.1e-05 25.3 6.6 1.1e-05 25.3 6.6 2.8 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 CDI85773.1 - 9.9e-05 22.6 10.1 9.9e-05 22.6 10.1 3.8 3 1 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 CDI85773.1 - 0.0015 18.4 6.1 0.0015 18.4 6.1 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) DUF1645 PF07816.11 CDI85773.1 - 0.01 16.4 2.5 0.01 16.4 2.5 10.2 11 2 0 11 11 11 0 Protein of unknown function (DUF1645) Spt20 PF12090.8 CDI85774.1 - 0.00014 21.5 9.5 0.00018 21.2 9.5 1.3 1 0 0 1 1 1 1 Spt20 family SpoIIP PF07454.11 CDI85774.1 - 0.0026 17.3 4.8 0.003 17.1 4.8 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) eIF-3_zeta PF05091.12 CDI85774.1 - 0.019 14.0 7.8 0.026 13.5 7.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI85774.1 - 0.023 14.7 16.4 0.028 14.4 16.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI85774.1 - 0.039 12.7 7.4 0.037 12.8 7.4 1.2 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CDI85774.1 - 0.083 13.9 6.8 0.17 12.8 6.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) V_ATPase_I PF01496.19 CDI85774.1 - 0.093 10.6 5.2 0.086 10.7 5.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Zip PF02535.22 CDI85774.1 - 0.19 10.9 4.9 0.24 10.6 4.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PBP1_TM PF14812.6 CDI85774.1 - 0.21 12.0 2.3 0.39 11.1 2.3 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RR_TM4-6 PF06459.12 CDI85774.1 - 0.23 11.3 13.8 0.015 15.2 8.7 1.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 FUSC PF04632.12 CDI85774.1 - 0.34 9.4 3.9 0.56 8.7 3.9 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Pex14_N PF04695.13 CDI85774.1 - 0.35 11.5 9.6 0.68 10.6 9.6 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Connexin PF00029.19 CDI85774.1 - 0.49 10.1 6.9 0.77 9.5 6.9 1.3 1 0 0 1 1 1 0 Connexin Hid1 PF12722.7 CDI85774.1 - 0.57 8.3 6.6 0.62 8.1 6.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pox_Ag35 PF03286.14 CDI85774.1 - 0.57 9.9 10.4 0.045 13.5 5.8 1.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein CSG2 PF16965.5 CDI85774.1 - 0.61 9.0 1.7 0.84 8.5 1.7 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator PAT1 PF09770.9 CDI85774.1 - 0.81 7.9 15.0 0.88 7.8 15.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RPN2_C PF18004.1 CDI85774.1 - 0.84 9.5 11.9 0.038 13.9 6.5 1.5 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain MscS_TM PF12794.7 CDI85774.1 - 1.2 7.9 8.8 2.1 7.1 8.8 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 HABP4_PAI-RBP1 PF04774.15 CDI85774.1 - 1.3 9.9 18.0 0.038 14.8 10.5 2.0 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family DUF1764 PF08576.10 CDI85774.1 - 4 8.4 11.8 0.37 11.7 6.7 1.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) DUF913 PF06025.12 CDI85774.1 - 5.6 5.8 10.7 4.7 6.1 9.8 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) Afi1 PF07792.12 CDI85774.1 - 5.8 7.4 11.6 13 6.3 11.6 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FAM176 PF14851.6 CDI85774.1 - 6.2 6.5 13.0 0.59 9.8 8.0 1.8 2 0 0 2 2 2 0 FAM176 family TFB6 PF17110.5 CDI85774.1 - 9 6.0 8.9 16 5.2 8.9 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CPSF100_C PF13299.6 CDI85775.1 - 0.016 15.4 7.2 0.016 15.4 7.2 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF3408 PF11888.8 CDI85775.1 - 0.02 15.0 10.8 0.021 15.0 10.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) V_ATPase_I PF01496.19 CDI85775.1 - 0.022 12.7 13.6 0.025 12.5 13.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 CDI85775.1 - 0.024 14.4 10.0 0.026 14.3 10.0 1.0 1 0 0 1 1 1 0 Connexin LETM1 PF07766.13 CDI85775.1 - 0.028 13.8 11.1 0.031 13.6 11.1 1.0 1 0 0 1 1 1 0 LETM1-like protein SpoIIP PF07454.11 CDI85775.1 - 0.045 13.2 14.5 0.049 13.1 14.5 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) eIF-3_zeta PF05091.12 CDI85775.1 - 0.054 12.5 16.9 0.054 12.5 16.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI85775.1 - 0.057 12.2 14.0 0.059 12.1 14.0 1.0 1 0 0 1 1 1 0 Presenilin DDHD PF02862.17 CDI85775.1 - 0.071 13.3 9.9 0.074 13.2 9.9 1.1 1 0 0 1 1 1 0 DDHD domain Peroxin-13_N PF04088.13 CDI85775.1 - 0.1 12.9 5.4 0.11 12.8 5.4 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region MecA PF05389.12 CDI85775.1 - 0.11 12.1 10.3 0.12 12.0 10.3 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) TERB2 PF15101.6 CDI85775.1 - 0.13 12.3 19.1 0.13 12.2 19.1 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Tim54 PF11711.8 CDI85775.1 - 0.13 11.0 11.1 0.15 10.9 11.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 EOS1 PF12326.8 CDI85775.1 - 0.15 12.0 5.8 0.15 12.0 5.8 1.1 1 0 0 1 1 1 0 N-glycosylation protein DUF913 PF06025.12 CDI85775.1 - 0.17 10.9 5.9 0.17 10.8 5.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RPA43_OB PF17875.1 CDI85775.1 - 0.17 12.5 10.8 0.19 12.4 10.8 1.0 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I FAM60A PF15396.6 CDI85775.1 - 0.17 11.8 9.4 0.19 11.7 9.4 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF4824 PF16106.5 CDI85775.1 - 0.18 11.1 12.6 0.2 10.9 12.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4824) Orf78 PF06024.12 CDI85775.1 - 0.18 12.1 6.3 0.22 11.8 6.3 1.3 1 0 0 1 1 1 0 Orf78 (ac78) RR_TM4-6 PF06459.12 CDI85775.1 - 0.2 11.4 13.8 0.22 11.3 13.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Folate_carrier PF01770.18 CDI85775.1 - 0.23 10.2 7.4 0.23 10.2 7.4 1.0 1 0 0 1 1 1 0 Reduced folate carrier Suf PF05843.14 CDI85775.1 - 0.26 11.3 18.6 0.28 11.1 18.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) OATP PF03137.20 CDI85775.1 - 0.26 9.5 7.8 0.28 9.4 7.8 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CLN3 PF02487.17 CDI85775.1 - 0.3 10.1 9.9 0.31 10.0 9.9 1.0 1 0 0 1 1 1 0 CLN3 protein Band_3_cyto PF07565.13 CDI85775.1 - 0.3 10.8 12.3 0.32 10.8 12.3 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF5308 PF17233.2 CDI85775.1 - 0.31 11.3 10.1 0.34 11.1 10.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF2828 PF11443.8 CDI85775.1 - 0.32 9.0 11.8 0.35 8.9 11.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4628 PF15429.6 CDI85775.1 - 0.34 10.6 10.0 0.36 10.5 10.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) CCDC53 PF10152.9 CDI85775.1 - 0.36 11.3 13.8 0.39 11.1 13.8 1.0 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Paf1 PF03985.13 CDI85775.1 - 0.39 9.7 18.4 0.53 9.2 18.4 1.2 1 0 0 1 1 1 0 Paf1 DUF4770 PF15994.5 CDI85775.1 - 0.43 10.8 16.9 0.5 10.6 16.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) ALMT PF11744.8 CDI85775.1 - 0.44 9.3 8.7 0.43 9.3 8.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CSG2 PF16965.5 CDI85775.1 - 0.44 9.4 6.2 0.43 9.5 6.2 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator SID-1_RNA_chan PF13965.6 CDI85775.1 - 0.49 8.7 6.1 0.5 8.7 6.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Neur_chan_memb PF02932.16 CDI85775.1 - 0.49 10.4 8.7 0.51 10.4 8.7 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4746 PF15928.5 CDI85775.1 - 0.53 9.7 9.8 0.56 9.6 9.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PPL5 PF18168.1 CDI85775.1 - 0.57 9.4 8.5 0.59 9.4 8.5 1.0 1 0 0 1 1 1 0 Prim-pol family 5 PAT1 PF09770.9 CDI85775.1 - 0.6 8.3 25.8 0.64 8.2 25.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EIIBC-GUT_N PF03612.14 CDI85775.1 - 0.64 9.7 13.0 0.71 9.6 13.0 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4820 PF16091.5 CDI85775.1 - 0.66 9.3 9.7 0.79 9.0 9.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TMEM174 PF15029.6 CDI85775.1 - 0.67 9.6 7.8 0.69 9.6 7.8 1.0 1 0 0 1 1 1 0 Transmembrane protein 174 Baculo_PP31 PF05311.11 CDI85775.1 - 0.75 9.2 13.5 0.84 9.1 13.5 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) PIP5K PF01504.18 CDI85775.1 - 0.83 8.8 13.2 0.91 8.7 13.2 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2126 PF09899.9 CDI85775.1 - 1 7.4 10.4 1.1 7.2 10.4 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Gti1_Pac2 PF09729.9 CDI85775.1 - 1.1 9.4 12.5 1.2 9.2 12.5 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family Pex14_N PF04695.13 CDI85775.1 - 1.2 9.8 25.6 1.4 9.6 25.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MPM1 PF17234.2 CDI85775.1 - 1.2 9.3 16.9 1.5 9.1 16.9 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 SLC12 PF03522.15 CDI85775.1 - 1.3 8.0 14.1 1.4 7.8 14.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CRF1 PF10380.9 CDI85775.1 - 1.5 9.2 5.9 2.2 8.6 5.9 1.4 1 0 0 1 1 1 0 Transcription factor CRF1 FAM176 PF14851.6 CDI85775.1 - 1.5 8.5 10.1 1.8 8.2 10.1 1.0 1 0 0 1 1 1 0 FAM176 family Serinc PF03348.15 CDI85775.1 - 1.5 7.6 13.1 1.6 7.5 13.1 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) HCO3_cotransp PF00955.21 CDI85775.1 - 1.6 7.5 5.9 1.6 7.4 5.9 1.0 1 0 0 1 1 1 0 HCO3- transporter family DUF4834 PF16118.5 CDI85775.1 - 1.7 9.6 21.2 2.5 9.1 21.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Ctr PF04145.15 CDI85775.1 - 2 9.0 8.0 2.2 8.9 8.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Otopetrin PF03189.13 CDI85775.1 - 2.1 7.1 8.6 2.1 7.0 8.6 1.0 1 0 0 1 1 1 0 Otopetrin ATAD4 PF15321.6 CDI85775.1 - 2.1 9.7 10.3 2.8 9.3 10.3 1.2 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 TFIIA PF03153.13 CDI85775.1 - 2.2 8.2 40.1 2.4 8.0 40.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4647 PF15504.6 CDI85775.1 - 2.2 7.3 17.2 2.4 7.2 17.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Peptidase_S49_N PF08496.10 CDI85775.1 - 2.5 8.1 15.1 3 7.9 15.1 1.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal AIF_C PF14721.6 CDI85775.1 - 2.6 8.4 13.4 3.1 8.1 13.4 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term G0-G1_switch_2 PF15103.6 CDI85775.1 - 2.7 8.4 12.0 3.6 8.1 12.0 1.1 1 0 0 1 1 1 0 G0/G1 switch protein 2 DUF3043 PF11241.8 CDI85775.1 - 2.8 8.0 10.4 3.1 7.8 10.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Kei1 PF08552.11 CDI85775.1 - 2.9 7.7 10.1 3.3 7.5 10.1 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF3464 PF11947.8 CDI85775.1 - 3.1 7.6 16.3 3.8 7.3 16.3 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 MDM10 PF12519.8 CDI85775.1 - 3.4 6.4 13.1 3.6 6.4 13.1 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 YABBY PF04690.13 CDI85775.1 - 3.7 8.1 11.4 4.1 7.9 11.4 1.1 1 0 0 1 1 1 0 YABBY protein FAM91_C PF14648.6 CDI85775.1 - 4 6.2 10.3 4.3 6.1 10.3 1.0 1 0 0 1 1 1 0 FAM91 C-terminus MTP18 PF10558.9 CDI85775.1 - 4.3 7.3 7.4 4.7 7.1 7.4 1.1 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) Nucleoside_tran PF01733.18 CDI85775.1 - 4.4 6.6 7.9 4.9 6.4 7.9 1.0 1 0 0 1 1 1 0 Nucleoside transporter Sec62 PF03839.16 CDI85775.1 - 4.4 6.7 11.7 5.3 6.5 11.7 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 AAA_28 PF13521.6 CDI85775.1 - 4.6 7.4 9.3 6.2 7.0 9.3 1.2 1 0 0 1 1 1 0 AAA domain DDRGK PF09756.9 CDI85775.1 - 4.7 6.8 22.0 5.6 6.5 22.0 1.0 1 0 0 1 1 1 0 DDRGK domain Zip PF02535.22 CDI85775.1 - 5 6.2 9.6 5.7 6.1 9.6 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter CobT PF06213.12 CDI85775.1 - 5.9 6.2 25.7 7.2 5.9 25.7 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT BRF1 PF07741.13 CDI85775.1 - 6.2 7.2 13.8 8 6.9 13.8 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain UPF0560 PF10577.9 CDI85775.1 - 7 5.0 25.3 8 4.8 25.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DcuA_DcuB PF03605.14 CDI85775.1 - 8.1 5.2 7.4 8.4 5.2 7.4 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter ORC_WH_C PF18137.1 CDI85775.1 - 8.2 6.5 16.7 10 6.2 16.7 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal FHIPEP PF00771.20 CDI85775.1 - 8.4 4.7 10.6 8.8 4.7 10.6 1.0 1 0 0 1 1 1 0 FHIPEP family MDM31_MDM32 PF08118.11 CDI85775.1 - 8.5 4.9 14.4 10 4.6 14.4 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Ureide_permease PF07168.11 CDI85775.1 - 9 4.9 9.1 10 4.7 9.1 1.0 1 0 0 1 1 1 0 Ureide permease MMU163 PF17119.5 CDI85775.1 - 9.1 5.3 9.4 11 5.1 9.4 1.0 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Velvet PF11754.8 CDI85775.1 - 9.2 6.1 18.0 10 6.0 18.0 1.0 1 0 0 1 1 1 0 Velvet factor PepSY_TM PF03929.16 CDI85775.1 - 9.3 5.8 11.5 9.9 5.7 11.5 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Nrap_D4 PF17405.2 CDI85779.1 - 3.7e-28 98.4 0.2 6.3e-28 97.6 0.2 1.2 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D3 PF17404.2 CDI85779.1 - 4.8e-16 59.2 0.0 2.1e-15 57.1 0.0 2.1 2 0 0 2 2 2 1 Nrap protein domain 3 Nrap_D5 PF17406.2 CDI85779.1 - 1.8e-13 50.6 0.0 4e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D2 PF17403.2 CDI85779.1 - 0.00022 21.0 0.3 0.0014 18.4 0.0 2.2 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain CDC45 PF02724.14 CDI85780.1 - 3.9 5.7 13.3 6.2 5.0 13.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Ank_2 PF12796.7 CDI85781.1 - 3.2e-25 88.5 0.0 8.8e-12 45.4 0.0 3.1 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI85781.1 - 2.1e-23 82.3 0.0 1.2e-13 51.3 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 CDI85781.1 - 4.9e-19 67.9 0.7 0.0012 19.2 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 CDI85781.1 - 6.2e-19 66.1 0.1 0.0006 20.1 0.0 6.1 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 CDI85781.1 - 1.7e-16 60.0 0.0 1.5e-05 25.1 0.0 4.8 2 2 3 5 5 5 3 Ankyrin repeats (many copies) VWA_3_C PF18571.1 CDI85781.1 - 0.048 13.5 0.3 2.5 8.0 0.1 2.5 2 0 0 2 2 2 0 von Willebrand factor type A C-terminal domain DUF4570 PF15134.6 CDI85781.1 - 0.06 13.4 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) TPH PF13868.6 CDI85783.1 - 5.8e-46 156.6 148.4 5.8e-46 156.6 148.4 2.2 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain dCMP_cyt_deam_1 PF00383.23 CDI85783.1 - 0.099 12.5 0.5 0.87 9.5 0.2 2.4 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region RPAP2_Rtr1 PF04181.13 CDI85784.1 - 0.0018 18.6 0.5 0.0018 18.6 0.5 2.2 2 0 0 2 2 2 1 Rtr1/RPAP2 family Cpn10 PF00166.21 CDI85785.1 - 7.8e-16 57.9 0.0 1e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Cas_csx3 PF09620.10 CDI85785.1 - 0.0043 16.9 0.1 0.0069 16.2 0.1 1.3 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_csx3) ThiF PF00899.21 CDI85786.1 - 2.2e-45 154.9 0.2 3.6e-45 154.2 0.2 1.3 1 1 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 CDI85786.1 - 0.00095 19.4 0.3 1.8 8.8 0.0 2.5 2 0 0 2 2 2 2 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CDI85786.1 - 0.0076 16.7 0.4 0.044 14.2 0.4 2.0 1 1 0 1 1 1 1 Putative NAD(P)-binding Arm PF00514.23 CDI85787.1 - 1.3e-05 25.1 17.1 0.3 11.2 0.0 9.5 10 0 0 10 10 10 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 CDI85787.1 - 0.00078 19.8 13.2 0.044 14.2 0.1 6.4 5 1 0 5 5 5 2 HEAT repeats AAA PF00004.29 CDI85789.1 - 0.00013 22.4 0.0 0.00022 21.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF2722 PF10846.8 CDI85790.1 - 0.0025 16.9 0.6 0.0025 16.9 0.6 6.2 5 1 1 6 6 6 2 Protein of unknown function (DUF2722) DUF1764 PF08576.10 CDI85791.1 - 4.9 8.1 16.0 6.1 7.8 16.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) TFIIA PF03153.13 CDI85792.1 - 0.004 17.2 27.2 0.0048 16.9 27.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF1211 PF06736.11 CDI85792.1 - 0.019 15.4 0.0 0.027 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1211) CENP-O PF09496.10 CDI85792.1 - 0.045 13.7 13.8 0.057 13.4 13.8 1.0 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component Presenilin PF01080.17 CDI85792.1 - 0.54 9.0 9.7 0.61 8.8 9.7 1.1 1 0 0 1 1 1 0 Presenilin GBP PF02263.19 CDI85792.1 - 1.6 7.9 12.7 3.5 6.8 9.9 2.0 1 1 1 2 2 2 0 Guanylate-binding protein, N-terminal domain Neur_chan_memb PF02932.16 CDI85792.1 - 4.9 7.1 8.8 6 6.8 8.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sec62 PF03839.16 CDI85792.1 - 7.9 5.9 8.8 11 5.4 8.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 PACT_coil_coil PF10495.9 CDI85792.1 - 8.5 7.0 13.8 1.9 9.2 1.7 2.2 2 0 0 2 2 2 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein SUIM_assoc PF16619.5 CDI85793.1 - 0.0022 18.0 4.8 0.0022 18.0 4.8 2.8 2 1 1 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 SPX PF03105.19 CDI85793.1 - 0.22 11.4 6.9 0.022 14.7 0.8 1.9 2 0 0 2 2 2 0 SPX domain DUF5345 PF17280.2 CDI85793.1 - 1.2 9.2 5.9 25 4.9 0.0 3.5 3 0 0 3 3 3 0 Family of unknown function (DUF5345) CCDC53 PF10152.9 CDI85793.1 - 1.2 9.5 9.5 7.8 6.9 0.9 3.8 3 1 0 3 3 3 0 Subunit CCDC53 of WASH complex DUF4667 PF15700.5 CDI85793.1 - 2.1 8.4 12.7 0.15 12.1 0.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4667) Spt20 PF12090.8 CDI85793.1 - 7.3 6.1 14.2 1.9 8.1 9.1 2.0 2 0 0 2 2 2 0 Spt20 family DUF2722 PF10846.8 CDI85794.1 - 5.9e-06 25.5 14.9 1.2e-05 24.5 12.5 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Folate_carrier PF01770.18 CDI85794.1 - 0.043 12.6 2.4 0.064 12.0 2.4 1.2 1 0 0 1 1 1 0 Reduced folate carrier PRAS PF15798.5 CDI85794.1 - 0.075 13.6 0.2 0.14 12.7 0.2 1.6 1 0 0 1 1 1 0 Proline-rich AKT1 substrate 1 MAGE PF01454.19 CDI85794.1 - 0.28 10.9 6.4 7.7 6.2 5.0 2.1 2 0 0 2 2 2 0 MAGE family Orf78 PF06024.12 CDI85794.1 - 0.38 11.1 5.4 14 6.0 3.5 2.2 2 0 0 2 2 2 0 Orf78 (ac78) CPSF100_C PF13299.6 CDI85794.1 - 0.66 10.1 6.0 0.3 11.3 2.2 1.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Spt20 PF12090.8 CDI85794.1 - 0.82 9.2 34.4 0.2 11.2 28.8 2.2 2 0 0 2 2 2 0 Spt20 family EPL1 PF10513.9 CDI85794.1 - 0.92 9.9 10.6 0.12 12.7 5.5 1.9 2 0 0 2 2 2 0 Enhancer of polycomb-like Suf PF05843.14 CDI85794.1 - 1.1 9.2 13.9 0.66 9.9 11.4 1.8 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) eIF-3_zeta PF05091.12 CDI85794.1 - 1.3 7.9 11.8 2.2 7.2 11.8 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3391 PF11871.8 CDI85794.1 - 1.3 9.5 10.4 0.52 10.8 4.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) Presenilin PF01080.17 CDI85794.1 - 1.5 7.5 9.1 2 7.1 8.0 1.7 2 0 0 2 2 2 0 Presenilin Ctr PF04145.15 CDI85794.1 - 2.8 8.6 3.9 1.7 9.3 1.8 1.7 2 0 0 2 2 2 0 Ctr copper transporter family Tim54 PF11711.8 CDI85794.1 - 3.6 6.3 8.5 0.56 8.9 4.7 1.5 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 YABBY PF04690.13 CDI85794.1 - 5.8 7.5 8.6 58 4.2 6.9 2.1 2 0 0 2 2 2 0 YABBY protein RRP36 PF06102.12 CDI85794.1 - 8.2 6.4 16.3 2.1 8.3 7.9 2.1 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 DUF3408 PF11888.8 CDI85794.1 - 8.2 6.6 11.7 0.51 10.5 5.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) SpoIIP PF07454.11 CDI85794.1 - 9.3 5.6 10.9 0.49 9.8 5.5 1.5 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) RR_TM4-6 PF06459.12 CDI85794.1 - 9.5 6.0 10.7 4.3 7.1 7.7 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Rrn6 PF10214.9 CDI85795.1 - 0.13 10.8 4.1 0.15 10.5 4.1 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor NHase_beta PF02211.15 CDI85795.1 - 0.37 10.8 2.4 0.6 10.1 0.0 2.1 2 0 0 2 2 2 0 Nitrile hydratase beta subunit DUF1720 PF08226.11 CDI85796.1 - 0.011 16.1 37.0 0.011 16.1 37.0 5.1 1 1 2 3 3 3 0 Domain of unknown function (DUF1720) V_ATPase_I PF01496.19 CDI85797.1 - 6.5e-47 160.0 14.1 6.5e-47 160.0 14.1 2.0 1 1 1 2 2 2 1 V-type ATPase 116kDa subunit family O-antigen_lig PF13425.6 CDI85797.1 - 0.0088 14.9 10.0 0.065 12.0 0.7 2.0 2 0 0 2 2 2 2 O-antigen ligase like membrane protein Connexin PF00029.19 CDI85797.1 - 0.011 15.5 21.5 0.17 11.7 6.1 2.3 1 1 1 2 2 2 0 Connexin Spore_coat_CotO PF14153.6 CDI85797.1 - 0.098 12.6 32.0 0.037 14.0 8.9 2.1 2 0 0 2 2 2 0 Spore coat protein CotO PTPRCAP PF15713.5 CDI85797.1 - 0.13 12.5 24.0 0.035 14.4 7.7 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Baculo_PP31 PF05311.11 CDI85797.1 - 0.15 11.6 13.6 0.58 9.6 2.6 2.2 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Orf78 PF06024.12 CDI85797.1 - 0.17 12.2 15.5 0.44 10.9 0.9 3.4 3 1 0 3 3 3 0 Orf78 (ac78) CcmH PF03918.14 CDI85797.1 - 0.24 10.7 15.8 0.14 11.5 0.9 3.1 3 0 0 3 3 3 0 Cytochrome C biogenesis protein CCSAP PF15748.5 CDI85797.1 - 0.24 11.5 20.4 1 9.5 4.6 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DUF3807 PF12720.7 CDI85797.1 - 0.35 11.1 30.0 1.7 8.9 14.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) TCP PF03634.13 CDI85797.1 - 0.43 11.1 19.6 0.56 10.8 4.0 2.2 2 0 0 2 2 2 0 TCP family transcription factor XRN_M PF17846.1 CDI85797.1 - 0.83 8.5 14.0 0.4 9.6 3.1 2.0 2 0 0 2 2 2 0 Xrn1 helical domain Conotoxin PF02950.17 CDI85797.1 - 1.1 10.3 19.7 1.1 10.3 2.5 3.2 3 0 0 3 3 3 0 Conotoxin Cytochrom_B_N_2 PF13631.6 CDI85797.1 - 1.1 9.2 0.0 1.1 9.2 0.0 2.5 2 1 1 3 3 3 0 Cytochrome b(N-terminal)/b6/petB PH_4 PF15404.6 CDI85797.1 - 1.2 8.9 13.5 5.4 6.8 3.6 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain DUF4834 PF16118.5 CDI85797.1 - 1.2 10.1 37.6 16 6.5 14.3 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) DUF2207 PF09972.9 CDI85797.1 - 1.3 7.7 0.0 1.3 7.7 0.0 2.6 1 1 2 3 3 3 0 Predicted membrane protein (DUF2207) SARAF PF06682.12 CDI85797.1 - 1.4 8.5 22.0 46 3.5 22.0 2.0 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4746 PF15928.5 CDI85797.1 - 1.5 8.1 15.9 0.21 11.0 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) ABC2_membrane_2 PF12679.7 CDI85797.1 - 1.6 8.0 9.9 6.3 6.0 0.1 2.5 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF5385 PF17359.2 CDI85797.1 - 2.2 7.8 22.2 5.6 6.5 4.0 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5385) Peptidase_S49_N PF08496.10 CDI85797.1 - 2.5 8.1 27.0 5.1 7.2 10.2 2.3 1 1 0 2 2 2 0 Peptidase family S49 N-terminal DUF2227 PF09988.9 CDI85797.1 - 2.9 7.7 12.8 0.12 12.3 0.5 2.8 2 1 0 2 2 2 0 Uncharacterized metal-binding protein (DUF2227) CLN3 PF02487.17 CDI85797.1 - 3.1 6.8 22.1 0.082 11.9 4.5 2.1 1 1 1 2 2 2 0 CLN3 protein EphA2_TM PF14575.6 CDI85797.1 - 3.8 8.5 23.0 1.6 9.6 2.8 3.2 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain CSG2 PF16965.5 CDI85797.1 - 3.9 6.3 14.6 0.38 9.7 1.2 2.1 1 1 1 2 2 2 0 Ceramide synthase regulator Frizzled PF01534.17 CDI85797.1 - 4 6.4 8.5 7.2 5.5 0.1 2.7 2 1 1 3 3 3 0 Frizzled/Smoothened family membrane region Dpy19 PF10034.9 CDI85797.1 - 5.8 5.0 15.1 0.19 9.9 0.5 2.4 1 1 1 2 2 2 0 Q-cell neuroblast polarisation GRP PF07172.11 CDI85797.1 - 9.2 7.0 18.8 3.6 8.3 0.1 3.2 2 1 1 3 3 3 0 Glycine rich protein family Folate_carrier PF01770.18 CDI85797.1 - 9.2 4.9 24.0 0.014 14.2 5.8 2.6 1 1 1 2 2 2 0 Reduced folate carrier MPM1 PF17234.2 CDI85797.1 - 9.9 6.4 25.5 5.5 7.2 8.2 2.9 3 0 0 3 3 3 0 Mitochondrial peculiar membrane protein 1 NOA36 PF06524.12 CDI85798.1 - 0.064 12.6 36.8 0.073 12.4 36.8 1.1 1 0 0 1 1 1 0 NOA36 protein Med15 PF09606.10 CDI85798.1 - 0.67 8.6 23.6 0.57 8.8 23.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI85799.1 - 1.3e-05 25.4 25.8 1.6e-05 25.1 25.8 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF4551 PF15087.6 CDI85799.1 - 0.0013 17.6 15.0 0.0014 17.6 15.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4551) DUF1772 PF08592.11 CDI85799.1 - 0.03 14.6 6.1 0.78 10.1 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) Phostensin_N PF13916.6 CDI85799.1 - 0.045 14.1 3.8 0.13 12.6 3.8 1.9 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Macoilin PF09726.9 CDI85799.1 - 0.047 12.2 31.4 0.06 11.9 31.4 1.1 1 0 0 1 1 1 0 Macoilin family DUF21 PF01595.20 CDI85799.1 - 0.088 12.5 0.2 0.088 12.5 0.2 2.4 2 2 0 2 2 2 0 Cyclin M transmembrane N-terminal domain RskA PF10099.9 CDI85799.1 - 0.11 12.8 28.7 0.8 10.0 0.4 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA CDK5_activator PF03261.15 CDI85799.1 - 0.12 11.9 12.7 0.14 11.7 12.7 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein SPX PF03105.19 CDI85799.1 - 0.88 9.4 32.3 1.1 9.1 32.3 1.1 1 0 0 1 1 1 0 SPX domain SLC12 PF03522.15 CDI85799.1 - 2.2 7.2 18.3 2.7 6.9 18.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 MMR1 PF08505.10 CDI85799.1 - 7.7 6.7 35.4 10 6.3 35.4 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein RskA PF10099.9 CDI85800.1 - 0.17 12.2 0.0 0.17 12.2 0.0 37.8 3 3 14 21 21 21 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI85801.1 - 0.0012 19.2 11.6 0.0013 19.0 11.6 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA SprA-related PF12118.8 CDI85801.1 - 0.036 13.2 18.8 0.044 12.9 18.8 1.1 1 0 0 1 1 1 0 SprA-related family BAF1_ABF1 PF04684.13 CDI85801.1 - 0.23 10.5 10.0 0.22 10.5 10.0 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SWI-SNF_Ssr4 PF08549.10 CDI85801.1 - 0.27 9.8 12.1 0.29 9.7 12.1 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) FAM60A PF15396.6 CDI85801.1 - 0.5 10.3 6.1 0.52 10.3 6.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A IHABP4_N PF16174.5 CDI85801.1 - 0.52 10.9 15.5 0.59 10.7 15.5 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal NPR3 PF03666.13 CDI85801.1 - 0.58 8.9 8.1 0.65 8.7 8.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CPSF100_C PF13299.6 CDI85801.1 - 0.61 10.2 7.2 0.71 10.0 7.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal TFIIA PF03153.13 CDI85801.1 - 0.85 9.5 21.4 0.93 9.4 21.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EOS1 PF12326.8 CDI85801.1 - 0.99 9.3 3.0 1.1 9.2 3.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein DDHD PF02862.17 CDI85801.1 - 1.1 9.4 7.8 1.3 9.2 7.8 1.1 1 0 0 1 1 1 0 DDHD domain Suf PF05843.14 CDI85801.1 - 1.6 8.6 12.1 1.7 8.6 12.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RR_TM4-6 PF06459.12 CDI85801.1 - 2.3 8.0 10.5 2.4 7.9 10.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spore_coat_CotO PF14153.6 CDI85801.1 - 2.7 7.9 14.7 2.9 7.8 14.7 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Neur_chan_memb PF02932.16 CDI85801.1 - 2.7 8.0 5.0 2.7 8.0 5.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI85801.1 - 2.9 6.5 13.5 3.3 6.4 13.5 1.0 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 CDI85801.1 - 3.7 6.8 11.8 4.2 6.6 11.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3915 PF13054.6 CDI85802.1 - 0.0042 17.1 0.5 0.0042 17.1 0.5 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3915) SLATT_1 PF18181.1 CDI85802.1 - 0.015 15.2 13.4 0.02 14.9 13.4 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 TFIIA PF03153.13 CDI85802.1 - 0.023 14.7 29.5 0.024 14.6 29.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SARAF PF06682.12 CDI85802.1 - 0.026 14.2 6.6 0.032 13.9 6.6 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis CD20 PF04103.15 CDI85802.1 - 0.1 12.7 0.9 0.19 11.8 0.9 1.3 1 0 0 1 1 1 0 CD20-like family FHIPEP PF00771.20 CDI85802.1 - 0.11 10.9 7.1 0.13 10.7 7.1 1.0 1 0 0 1 1 1 0 FHIPEP family LCE PF14672.6 CDI85802.1 - 0.18 12.4 6.2 0.35 11.5 6.2 1.6 1 1 0 1 1 1 0 Late cornified envelope Velvet PF11754.8 CDI85802.1 - 0.2 11.5 10.8 0.24 11.3 10.8 1.1 1 0 0 1 1 1 0 Velvet factor Neur_chan_memb PF02932.16 CDI85802.1 - 0.24 11.4 7.8 0.26 11.3 7.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SUIM_assoc PF16619.5 CDI85802.1 - 0.43 10.7 25.1 2.3e+02 1.9 25.1 2.5 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 FAM199X PF15814.5 CDI85802.1 - 0.46 9.5 9.8 0.53 9.3 9.8 1.0 1 0 0 1 1 1 0 Protein family FAM199X Endostatin PF06482.11 CDI85802.1 - 0.46 9.9 11.7 0.51 9.8 11.7 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Tic110 PF16940.5 CDI85802.1 - 0.49 8.8 7.9 0.56 8.6 7.9 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter Hydin_ADK PF17213.3 CDI85802.1 - 0.58 10.4 15.6 0.76 10.0 15.6 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain RAB3GAP2_N PF14655.6 CDI85802.1 - 0.88 8.8 7.5 1.1 8.4 7.5 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus SAPS PF04499.15 CDI85802.1 - 0.97 8.1 11.6 1.1 7.9 11.6 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RskA PF10099.9 CDI85802.1 - 1.1 9.5 38.3 5.6 7.2 37.6 1.9 1 1 1 2 2 2 0 Anti-sigma-K factor rskA PNISR PF15996.5 CDI85802.1 - 1.2 9.4 20.0 1.3 9.2 20.0 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR eIF-3_zeta PF05091.12 CDI85802.1 - 1.4 7.8 10.5 1.5 7.7 10.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4820 PF16091.5 CDI85802.1 - 1.4 8.2 9.0 2.1 7.7 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TMEM247 PF15444.6 CDI85802.1 - 1.4 8.9 8.6 1.9 8.5 8.6 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 DDHD PF02862.17 CDI85802.1 - 1.5 8.9 10.5 1.9 8.6 10.5 1.2 1 0 0 1 1 1 0 DDHD domain DUF2512 PF10710.9 CDI85802.1 - 1.9 8.1 3.6 3.4 7.3 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2512) V_ATPase_I PF01496.19 CDI85802.1 - 1.9 6.3 8.6 2.1 6.2 8.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Zip PF02535.22 CDI85802.1 - 2.2 7.4 8.7 2.3 7.3 8.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter XRN_M PF17846.1 CDI85802.1 - 3.1 6.7 10.6 3.7 6.4 10.6 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Serinc PF03348.15 CDI85802.1 - 3.5 6.4 4.8 3.7 6.4 4.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) PAT1 PF09770.9 CDI85802.1 - 3.7 5.7 23.9 3.7 5.7 23.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF5427 PF10310.9 CDI85802.1 - 3.9 6.3 18.6 4.7 6.1 18.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SLC12 PF03522.15 CDI85802.1 - 5.7 5.9 9.5 6 5.8 9.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Suf PF05843.14 CDI85802.1 - 6 6.8 19.1 7.7 6.4 19.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CoA_transf_3 PF02515.17 CDI85802.1 - 6.6 5.7 17.7 7.6 5.5 17.7 1.0 1 0 0 1 1 1 0 CoA-transferase family III R_equi_Vir PF05526.11 CDI85802.1 - 6.7 6.5 13.6 9.5 6.0 13.6 1.3 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein GREB1 PF15782.5 CDI85802.1 - 7.7 3.5 15.4 7.8 3.5 15.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Nop53 PF07767.11 CDI85802.1 - 9.7 5.5 21.6 12 5.1 21.6 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) BAF1_ABF1 PF04684.13 CDI85803.1 - 0.27 10.3 13.4 0.33 10.0 13.4 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SAPS PF04499.15 CDI85803.1 - 0.58 8.9 8.8 0.7 8.6 8.8 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SPX PF03105.19 CDI85803.1 - 0.72 9.7 23.8 0.84 9.5 23.8 1.0 1 0 0 1 1 1 0 SPX domain SLC12 PF03522.15 CDI85803.1 - 2.2 7.2 10.8 2.9 6.8 10.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 V_ATPase_I PF01496.19 CDI85803.1 - 2.7 5.8 8.8 3.9 5.3 8.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mucin PF01456.17 CDI85803.1 - 3.5 7.6 19.7 5.2 7.1 19.7 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein QWRF PF04484.12 CDI85803.1 - 3.8 7.2 19.3 4.8 6.8 19.3 1.1 1 0 0 1 1 1 0 QWRF family DUF4551 PF15087.6 CDI85803.1 - 6.4 5.5 18.8 7.4 5.3 18.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Helicase_C_2 PF13307.6 CDI85804.1 - 8.6e-22 78.1 11.0 8.6e-22 78.1 11.0 4.3 3 2 1 4 4 3 1 Helicase C-terminal domain DUF4647 PF15504.6 CDI85804.1 - 0.00015 21.1 11.0 0.00015 21.1 11.0 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF4647) DUF4407 PF14362.6 CDI85804.1 - 0.0043 16.5 1.6 0.0043 16.5 1.6 5.2 2 1 0 3 3 1 1 Domain of unknown function (DUF4407) DUF2722 PF10846.8 CDI85804.1 - 0.0048 15.9 4.1 0.0048 15.9 4.1 5.4 4 1 1 5 5 3 3 Protein of unknown function (DUF2722) BRF1 PF07741.13 CDI85804.1 - 0.01 16.2 8.9 0.01 16.2 8.9 5.3 4 1 0 4 4 3 0 Brf1-like TBP-binding domain SelP_N PF04592.14 CDI85804.1 - 0.011 15.2 1.7 0.011 15.2 1.7 4.0 4 0 0 4 4 3 0 Selenoprotein P, N terminal region CAF1 PF04857.20 CDI85804.1 - 0.032 13.4 0.0 0.032 13.4 0.0 3.4 2 2 0 2 2 1 0 CAF1 family ribonuclease YABBY PF04690.13 CDI85804.1 - 0.035 14.7 1.4 0.035 14.7 1.4 4.6 4 0 0 4 4 4 0 YABBY protein Velvet PF11754.8 CDI85804.1 - 0.11 12.4 0.0 0.11 12.4 0.0 4.2 2 2 0 2 2 1 0 Velvet factor DUF4366 PF14283.6 CDI85804.1 - 2.7 8.0 28.7 0.026 14.6 5.2 4.7 4 1 1 5 5 5 0 Domain of unknown function (DUF4366) MRP-S31 PF15433.6 CDI85804.1 - 3.6 7.2 52.7 0.63 9.6 37.7 3.2 3 0 0 3 3 3 0 Mitochondrial 28S ribosomal protein S31 Isy1 PF06246.12 CDI85804.1 - 6.6 6.2 43.8 1.7 8.1 8.1 4.2 4 0 0 4 4 4 0 Isy1-like splicing family CCDC106 PF15794.5 CDI85805.1 - 1.8 8.2 31.4 1.9 8.1 31.4 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 PPP4R2 PF09184.11 CDI85805.1 - 3.7 7.1 22.9 4 7.0 22.9 1.0 1 0 0 1 1 1 0 PPP4R2 DUF4820 PF16091.5 CDI85805.1 - 4.5 6.6 25.5 5.9 6.2 25.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) SR-25 PF10500.9 CDI85805.1 - 5.6 6.5 36.6 9.5 5.8 34.7 1.8 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Suf PF05843.14 CDI85805.1 - 5.9 6.8 37.7 6.5 6.7 37.7 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF5523 PF17661.1 CDI85805.1 - 7.5 6.2 23.0 9 5.9 23.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF3381 PF11861.8 CDI85805.1 - 9 6.1 25.3 12 5.6 25.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Jak1_Phl PF17887.1 CDI85805.1 - 9.2 6.2 23.3 11 6.0 23.3 1.1 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain SMYLE_N PF18615.1 CDI85805.1 - 9.9 5.6 23.8 12 5.3 23.8 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain CLN3 PF02487.17 CDI85807.1 - 0.44 9.5 23.7 0.49 9.4 23.7 1.1 1 0 0 1 1 1 0 CLN3 protein NPR3 PF03666.13 CDI85807.1 - 0.45 9.2 29.9 0.48 9.2 29.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 CDI85807.1 - 1.2 7.8 41.0 1.4 7.6 41.0 1.0 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 CDI85807.1 - 1.7 7.5 18.3 2.2 7.1 18.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 CDI85807.1 - 2 8.1 35.0 2.3 8.0 35.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2370 PF10176.9 CDI85807.1 - 2.1 7.9 16.8 2.9 7.5 16.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Raftlin PF15250.6 CDI85807.1 - 4.3 6.0 26.8 4.3 6.0 26.8 1.0 1 0 0 1 1 1 0 Raftlin FAM60A PF15396.6 CDI85807.1 - 4.5 7.2 29.5 4.7 7.2 29.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF5427 PF10310.9 CDI85807.1 - 4.6 6.1 33.5 5.2 5.9 33.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) PBP1_TM PF14812.6 CDI85807.1 - 4.6 7.7 16.4 13 6.2 16.4 1.7 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Zip PF02535.22 CDI85807.1 - 6.2 5.9 27.6 6.7 5.8 27.6 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter CCSAP PF15748.5 CDI85807.1 - 6.6 6.8 38.6 7.3 6.7 38.6 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF2828 PF11443.8 CDI85807.1 - 7.4 4.5 32.1 8.3 4.4 32.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Neur_chan_memb PF02932.16 CDI85807.1 - 7.5 6.5 27.5 10 6.1 27.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HCO3_cotransp PF00955.21 CDI85807.1 - 8.1 5.1 17.7 8.6 5.1 17.7 1.0 1 0 0 1 1 1 0 HCO3- transporter family DUF4834 PF16118.5 CDI85809.1 - 0.00016 22.5 6.5 0.00021 22.2 6.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) TMEM208_SND2 PF05620.11 CDI85809.1 - 0.0015 18.4 4.7 0.0019 18.0 4.7 1.2 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 Connexin PF00029.19 CDI85809.1 - 0.0023 17.7 2.7 0.0023 17.7 2.7 1.2 1 0 0 1 1 1 1 Connexin FHIPEP PF00771.20 CDI85809.1 - 0.0044 15.6 5.4 0.0044 15.6 5.4 1.0 1 0 0 1 1 1 1 FHIPEP family Afi1 PF07792.12 CDI85809.1 - 0.0044 17.5 5.9 0.0045 17.5 5.9 1.1 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF1980 PF09323.10 CDI85809.1 - 0.0046 16.9 4.9 0.005 16.8 4.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1980) DcuA_DcuB PF03605.14 CDI85809.1 - 0.016 14.1 3.1 0.016 14.1 3.1 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter ATG22 PF11700.8 CDI85809.1 - 0.019 13.6 2.0 0.019 13.6 2.0 1.0 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like FAM176 PF14851.6 CDI85809.1 - 0.019 14.6 1.6 0.02 14.6 1.6 1.1 1 0 0 1 1 1 0 FAM176 family CLN3 PF02487.17 CDI85809.1 - 0.03 13.4 4.0 0.031 13.3 4.0 1.0 1 0 0 1 1 1 0 CLN3 protein CBP_BcsG PF11658.8 CDI85809.1 - 0.04 12.3 5.7 0.04 12.3 5.7 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG OATP PF03137.20 CDI85809.1 - 0.043 12.1 3.1 0.042 12.1 3.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3533 PF12051.8 CDI85809.1 - 0.045 12.7 1.5 0.046 12.6 1.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) RskA PF10099.9 CDI85809.1 - 0.046 14.0 9.5 0.054 13.8 9.5 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Herpes_glycop PF01528.16 CDI85809.1 - 0.049 12.5 1.3 0.051 12.4 1.3 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein M DUF4175 PF13779.6 CDI85809.1 - 0.068 11.1 21.2 0.061 11.2 21.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CD20 PF04103.15 CDI85809.1 - 0.084 13.0 0.2 0.088 12.9 0.2 1.1 1 0 0 1 1 1 0 CD20-like family SID-1_RNA_chan PF13965.6 CDI85809.1 - 0.084 11.3 2.8 0.083 11.3 2.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TFB6 PF17110.5 CDI85809.1 - 0.097 12.4 8.6 0.11 12.3 8.6 1.0 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH TERB2 PF15101.6 CDI85809.1 - 0.12 12.4 13.6 0.12 12.5 13.6 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 AAA_24 PF13479.6 CDI85809.1 - 0.13 12.0 2.6 0.14 11.8 2.6 1.1 1 0 0 1 1 1 0 AAA domain V_ATPase_I PF01496.19 CDI85809.1 - 0.14 10.1 8.6 0.13 10.2 8.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S49_N PF08496.10 CDI85809.1 - 0.15 12.1 8.3 0.16 12.0 8.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Folate_carrier PF01770.18 CDI85809.1 - 0.16 10.7 4.0 0.16 10.7 4.0 1.1 1 0 0 1 1 1 0 Reduced folate carrier Serinc PF03348.15 CDI85809.1 - 0.16 10.8 4.7 0.19 10.6 4.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ctr PF04145.15 CDI85809.1 - 0.2 12.3 3.9 0.22 12.1 3.9 1.1 1 0 0 1 1 1 0 Ctr copper transporter family HA2 PF04408.23 CDI85809.1 - 0.2 12.0 3.8 0.2 11.9 3.8 1.1 1 0 0 1 1 1 0 Helicase associated domain (HA2) CSG2 PF16965.5 CDI85809.1 - 0.26 10.2 3.6 0.26 10.2 3.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator EOS1 PF12326.8 CDI85809.1 - 0.27 11.1 2.1 0.26 11.2 2.1 1.2 1 0 0 1 1 1 0 N-glycosylation protein Pex26 PF07163.12 CDI85809.1 - 0.32 10.3 11.8 0.32 10.3 11.8 1.0 1 0 0 1 1 1 0 Pex26 protein Ureide_permease PF07168.11 CDI85809.1 - 0.34 9.6 1.9 0.34 9.6 1.9 1.1 1 0 0 1 1 1 0 Ureide permease Dpy19 PF10034.9 CDI85809.1 - 0.4 8.8 4.3 0.38 8.9 4.3 1.0 1 0 0 1 1 1 0 Q-cell neuroblast polarisation Spt20 PF12090.8 CDI85809.1 - 0.4 10.3 37.3 0.41 10.2 37.3 1.1 1 0 0 1 1 1 0 Spt20 family ABC2_membrane_2 PF12679.7 CDI85809.1 - 0.49 9.6 6.0 0.58 9.4 6.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Eapp_C PF10238.9 CDI85809.1 - 0.49 10.5 13.3 0.57 10.3 13.3 1.0 1 0 0 1 1 1 0 E2F-associated phosphoprotein R_equi_Vir PF05526.11 CDI85809.1 - 0.52 10.1 3.9 0.54 10.1 3.9 1.0 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein 7TM_GPCR_Srx PF10328.9 CDI85809.1 - 0.73 9.4 3.8 1.2 8.7 3.8 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx AIF_C PF14721.6 CDI85809.1 - 0.87 9.9 8.1 0.88 9.9 8.1 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term O-antigen_lig PF13425.6 CDI85809.1 - 0.97 8.1 1.9 0.99 8.1 1.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DDHD PF02862.17 CDI85809.1 - 0.97 9.5 8.9 0.96 9.6 8.9 1.1 1 0 0 1 1 1 0 DDHD domain NEMP PF10225.9 CDI85809.1 - 1.4 8.5 4.6 1.6 8.4 4.6 1.1 1 0 0 1 1 1 0 NEMP family SpoIIP PF07454.11 CDI85809.1 - 1.6 8.1 12.9 1.6 8.1 12.9 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF3464 PF11947.8 CDI85809.1 - 1.8 8.3 11.4 1.8 8.3 11.4 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 PepSY_TM PF03929.16 CDI85809.1 - 2.2 7.9 5.1 2.1 8.0 5.1 1.2 1 0 0 1 1 1 0 PepSY-associated TM region UPF0560 PF10577.9 CDI85809.1 - 2.4 6.5 16.8 2.2 6.6 16.8 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 eIF-3_zeta PF05091.12 CDI85809.1 - 2.9 6.8 16.2 2.9 6.8 16.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI85809.1 - 6.3 6.7 32.6 6.4 6.7 32.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EIIBC-GUT_N PF03612.14 CDI85809.1 - 6.5 6.5 13.2 6.8 6.4 13.2 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DivIC PF04977.15 CDI85809.1 - 8.3 6.3 22.9 13 5.6 22.9 1.3 1 0 0 1 1 1 0 Septum formation initiator Suf PF05843.14 CDI85809.1 - 9.6 6.1 18.0 9.2 6.2 18.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2235 PF09994.9 CDI85810.1 - 9.5 5.5 19.8 16 4.7 19.8 1.4 1 1 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF3224 PF11528.8 CDI85813.1 - 0.0028 17.5 1.3 0.019 14.8 1.3 2.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3224) Spt20 PF12090.8 CDI85813.1 - 0.0045 16.6 5.4 0.0045 16.6 5.4 5.9 4 2 1 5 5 5 2 Spt20 family PALP PF00291.25 CDI85814.1 - 2.1e-48 165.3 2.4 1.7e-47 162.2 2.4 2.2 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Med3 PF11593.8 CDI85816.1 - 0.0012 18.2 1.9 0.0012 18.1 1.9 1.1 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Spt20 PF12090.8 CDI85816.1 - 0.027 14.1 4.3 0.029 14.0 4.3 1.1 1 0 0 1 1 1 0 Spt20 family BBS2_N PF14781.6 CDI85816.1 - 0.057 13.3 0.3 0.086 12.8 0.3 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, N-terminal SARAF PF06682.12 CDI85817.1 - 0.00046 19.9 1.2 0.00077 19.2 1.2 1.4 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis DUF5427 PF10310.9 CDI85817.1 - 0.0041 16.1 4.7 0.0041 16.1 4.7 1.6 2 0 0 2 2 2 1 Family of unknown function (DUF5427) Hamartin PF04388.12 CDI85817.1 - 0.22 10.1 4.9 0.25 10.0 4.9 1.2 1 0 0 1 1 1 0 Hamartin protein DUF5613 PF18467.1 CDI85817.1 - 0.23 11.9 0.3 0.23 11.9 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5613) DUF4813 PF16072.5 CDI85817.1 - 3.2 7.3 38.8 0.25 11.0 18.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4813) Dehydrin PF00257.19 CDI85817.1 - 4.2 7.9 19.1 0.044 14.4 2.0 2.6 3 0 0 3 3 3 0 Dehydrin RCC1_2 PF13540.6 CDI85818.1 - 1e-25 88.9 31.2 7.3e-08 32.0 3.0 6.7 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 CDI85818.1 - 4.7e-24 84.8 25.6 7.3e-08 32.9 0.1 9.0 8 3 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat DUF1645 PF07816.11 CDI85818.1 - 0.04 14.5 0.9 0.04 14.5 0.9 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF1645) DUF2722 PF10846.8 CDI85818.1 - 8.6 5.2 34.6 0.05 12.6 4.3 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2722) Secretin_N_2 PF07655.13 CDI85818.1 - 9.9 6.8 28.8 0.042 14.4 3.4 4.8 5 0 0 5 5 5 0 Secretin N-terminal domain SUIM_assoc PF16619.5 CDI85820.1 - 0.0013 18.7 0.7 0.0013 18.7 0.7 10.0 9 3 1 10 10 10 3 Unstructured region C-term to UIM in Ataxin3 DFRP_C PF16543.5 CDI85820.1 - 0.17 12.4 0.2 0.17 12.4 0.2 5.1 5 1 0 5 5 5 0 DRG Family Regulatory Proteins, Tma46 LRR_4 PF12799.7 CDI85821.1 - 9.8e-33 111.7 30.9 1.4e-09 38.1 2.2 6.2 3 2 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI85821.1 - 2.2e-26 91.4 20.3 4.5e-11 42.4 0.3 4.9 2 2 3 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 CDI85821.1 - 2.1e-14 53.4 13.7 1.3e-05 24.7 4.1 3.5 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 CDI85821.1 - 7.8e-05 22.4 26.3 0.13 12.3 0.8 7.7 8 0 0 8 8 8 2 Leucine Rich repeat LRR_1 PF00560.33 CDI85821.1 - 0.0002 21.5 23.7 0.75 10.6 0.1 7.9 7 1 0 7 7 7 2 Leucine Rich Repeat Kre28 PF17097.5 CDI85821.1 - 0.0054 15.7 1.2 0.0087 15.1 1.2 1.3 1 0 0 1 1 1 1 Spindle pole body component DUF2322 PF10084.9 CDI85821.1 - 0.29 11.2 1.8 4.6 7.3 0.3 2.8 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2322) DUF2339 PF10101.9 CDI85823.1 - 7.5 5.0 23.2 8.7 4.8 23.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) Trp_oprn_chp PF09534.10 CDI85823.1 - 9.5 6.0 37.7 19 5.0 37.7 1.6 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Shadoo PF14999.6 CDI85824.1 - 0.033 14.3 12.2 0.044 13.9 12.2 1.1 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective MMU163 PF17119.5 CDI85824.1 - 0.7 9.0 8.8 0.72 9.0 8.8 1.0 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis RskA PF10099.9 CDI85824.1 - 2.7 8.2 21.0 3.5 7.9 21.0 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF3824 PF12868.7 CDI85824.1 - 3 8.5 17.5 3.6 8.2 17.5 1.1 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Ctr PF04145.15 CDI85824.1 - 7.9 7.1 6.7 9.1 6.9 6.7 1.1 1 0 0 1 1 1 0 Ctr copper transporter family COPI_assoc PF08507.10 CDI85825.1 - 0.004 17.2 0.3 0.004 17.2 0.3 4.0 2 1 2 4 4 4 1 COPI associated protein Utp14 PF04615.13 CDI85825.1 - 0.085 11.4 51.6 0.11 11.1 51.6 1.0 1 0 0 1 1 1 0 Utp14 protein OAD_gamma PF04277.13 CDI85825.1 - 1.2 9.7 0.0 1.2 9.7 0.0 4.5 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain TFIIA PF03153.13 CDI85826.1 - 0.17 11.8 13.6 0.17 11.8 13.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM222A PF15258.6 CDI85826.1 - 4.3 6.3 13.1 4.3 6.3 13.1 1.1 1 0 0 1 1 1 0 Protein family of FAM222A DUF572 PF04502.13 CDI85827.1 - 1 8.9 9.2 1.2 8.7 9.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Neur_chan_memb PF02932.16 CDI85827.1 - 3.8 7.5 6.0 4.8 7.2 6.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GREB1 PF15782.5 CDI85827.1 - 4.2 4.4 15.7 4.5 4.3 15.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 CDI85827.1 - 5.2 5.1 10.0 5.7 4.9 10.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1635 PF07795.11 CDI85830.1 - 0.01 15.7 0.1 0.01 15.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Sec16_N PF12935.7 CDI85830.1 - 6.2 6.9 9.9 0.14 12.3 3.4 1.5 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 N-terminus SARAF PF06682.12 CDI85831.1 - 0.0038 16.9 8.4 0.0048 16.6 8.4 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis BAF1_ABF1 PF04684.13 CDI85831.1 - 0.013 14.6 17.9 0.016 14.3 17.9 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF2052 PF09747.9 CDI85831.1 - 0.02 15.0 17.1 0.029 14.5 17.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4366 PF14283.6 CDI85831.1 - 0.037 14.1 9.3 0.064 13.3 8.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) IER PF05760.12 CDI85831.1 - 0.058 13.7 19.9 0.067 13.5 19.9 1.0 1 0 0 1 1 1 0 Immediate early response protein (IER) AAA_23 PF13476.6 CDI85831.1 - 0.31 11.5 13.2 0.35 11.3 13.2 1.2 1 0 0 1 1 1 0 AAA domain INSIG PF07281.12 CDI85831.1 - 0.32 10.6 8.7 1.8 8.2 8.4 2.0 1 1 1 2 2 2 0 Insulin-induced protein (INSIG) TAF4 PF05236.14 CDI85831.1 - 0.38 10.5 20.2 0.51 10.0 20.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family SLC12 PF03522.15 CDI85831.1 - 0.53 9.2 14.0 0.62 9.0 14.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI85831.1 - 0.6 10.1 11.9 0.71 9.9 11.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Macoilin PF09726.9 CDI85831.1 - 0.67 8.4 13.5 0.83 8.1 13.5 1.1 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 CDI85831.1 - 0.74 8.6 13.3 0.88 8.4 13.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain CemA PF03040.14 CDI85831.1 - 1.2 9.0 4.8 1.2 9.0 4.8 1.1 1 0 0 1 1 1 0 CemA family Lin-8 PF03353.15 CDI85831.1 - 1.2 8.6 19.4 1.8 8.0 19.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SRP-alpha_N PF04086.13 CDI85831.1 - 1.2 9.0 18.8 1.6 8.6 18.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SOG2 PF10428.9 CDI85831.1 - 1.4 8.1 17.2 1.6 7.8 17.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein GAGA_bind PF06217.12 CDI85831.1 - 1.6 9.0 12.6 1.8 8.8 12.6 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family RskA PF10099.9 CDI85831.1 - 1.7 8.9 33.6 2.5 8.4 3.7 2.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA PsbQ PF05757.11 CDI85831.1 - 1.7 8.4 19.2 0.16 11.7 14.3 1.7 1 1 1 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) DUF4710 PF15828.5 CDI85831.1 - 1.9 8.7 7.8 3 8.0 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) FAM176 PF14851.6 CDI85831.1 - 2 8.1 13.6 6.5 6.4 13.6 1.9 1 1 0 1 1 1 0 FAM176 family SPATIAL PF15256.6 CDI85831.1 - 2.3 8.5 16.1 0.27 11.5 10.2 1.9 1 1 1 2 2 2 0 SPATIAL DUF4554 PF15091.6 CDI85831.1 - 2.6 6.8 17.6 3.2 6.6 17.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) PAT1 PF09770.9 CDI85831.1 - 2.8 6.1 26.3 3.3 5.9 26.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PA26 PF04636.13 CDI85831.1 - 2.9 6.7 11.7 3.6 6.4 11.7 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Asp-B-Hydro_N PF05279.11 CDI85831.1 - 3 7.9 14.2 3.8 7.5 14.2 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF1645 PF07816.11 CDI85831.1 - 3.2 8.3 23.3 76 3.8 23.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1645) DUF572 PF04502.13 CDI85831.1 - 3.3 7.2 15.9 4.3 6.9 15.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF3292 PF11696.8 CDI85831.1 - 3.9 5.7 12.9 4.9 5.4 12.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF45 PF01863.17 CDI85831.1 - 4 7.4 9.7 4.8 7.2 9.7 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF45 CDC45 PF02724.14 CDI85831.1 - 5.6 5.1 19.0 7.1 4.8 19.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S64 PF08192.11 CDI85831.1 - 6 5.2 16.3 7.3 4.9 16.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 Ldh_1_C PF02866.18 CDI85831.1 - 6.7 6.6 10.2 1.1 9.1 6.7 1.4 1 1 0 1 1 1 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain DUF5427 PF10310.9 CDI85831.1 - 8.5 5.2 23.9 10 5.0 23.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) EMC3_TMCO1 PF01956.16 CDI85831.1 - 8.6 6.1 7.7 11 5.7 7.7 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Sporozoite_P67 PF05642.11 CDI85831.1 - 9.2 4.2 13.1 11 3.9 13.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ndc1_Nup PF09531.10 CDI85831.1 - 9.2 4.8 19.7 11 4.5 19.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Trp_oprn_chp PF09534.10 CDI85831.1 - 9.7 5.9 19.4 1.1e+02 2.5 19.3 2.2 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Tam41_Mmp37 PF09139.11 CDI85831.1 - 9.7 5.5 12.3 11 5.3 12.3 1.0 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial FHIPEP PF00771.20 CDI85832.1 - 1.1 7.7 7.7 1.3 7.4 7.7 1.1 1 0 0 1 1 1 0 FHIPEP family Cation_ATPase PF13246.6 CDI85832.1 - 1.7 8.8 4.9 3.8 7.7 4.9 1.7 1 1 0 1 1 1 0 Cation transport ATPase (P-type) DUF1180 PF06679.12 CDI85832.1 - 2.4 8.5 9.8 2.9 8.3 9.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Nuc_deoxyrib_tr PF05014.15 CDI85832.1 - 4.2 7.4 6.4 5.1 7.1 6.4 1.1 1 0 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase Hydin_ADK PF17213.3 CDI85832.1 - 4.4 7.5 14.1 6 7.1 14.1 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Connexin PF00029.19 CDI85832.1 - 4.6 6.9 11.6 5.4 6.7 11.6 1.1 1 0 0 1 1 1 0 Connexin DUF4484 PF14831.6 CDI85832.1 - 5.8 6.9 14.5 6.7 6.7 14.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) V_ATPase_I PF01496.19 CDI85832.1 - 6.4 4.6 17.4 7.6 4.3 17.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SpoIIP PF07454.11 CDI85832.1 - 6.7 6.1 16.9 8 5.8 16.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CDI85832.1 - 7 5.3 18.6 7.3 5.2 18.6 1.0 1 0 0 1 1 1 0 Presenilin GBP_C PF02841.14 CDI85832.1 - 8.9 5.6 25.6 10 5.4 25.6 1.0 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain HIG_1_N PF04588.13 CDI85833.1 - 0.078 13.2 0.2 0.078 13.2 0.2 3.3 2 1 0 2 2 2 0 Hypoxia induced protein conserved region Tmemb_185A PF10269.9 CDI85833.1 - 0.52 10.0 2.5 1.7 8.2 2.5 1.9 1 0 0 1 1 1 0 Transmembrane Fragile-X-F protein KASH PF10541.9 CDI85833.1 - 0.93 9.8 4.3 2.2 8.6 4.3 1.5 1 0 0 1 1 1 0 Nuclear envelope localisation domain DUF4207 PF13904.6 CDI85834.1 - 0.00069 19.4 16.3 0.00069 19.4 16.3 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF4207) ANAPC_CDC26 PF10471.9 CDI85834.1 - 0.023 15.5 9.5 0.023 15.5 9.5 4.6 4 1 0 4 4 4 0 Anaphase-promoting complex APC subunit CDC26 IMUP PF15761.5 CDI85834.1 - 0.11 13.2 0.2 0.11 13.2 0.2 4.6 4 1 1 5 5 5 0 Immortalisation up-regulated protein FUN14 PF04930.15 CDI85834.1 - 0.14 12.6 4.1 0.14 12.6 0.7 2.5 3 0 0 3 3 3 0 FUN14 family Bacteriocin_IIc PF10439.9 CDI85834.1 - 0.63 10.2 23.9 0.35 11.0 21.8 1.6 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide PDDEXK_6 PF04720.12 CDI85834.1 - 1.8 8.5 11.1 2.8 7.8 1.0 2.5 2 0 0 2 2 2 0 PDDEXK-like family of unknown function DUF4179 PF13786.6 CDI85834.1 - 3.7 8.1 4.7 27 5.3 4.6 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) Lipase_GDSL PF00657.22 CDI85834.1 - 8.9 6.2 9.7 1.7 8.6 0.1 2.7 3 0 0 3 3 3 0 GDSL-like Lipase/Acylhydrolase RAP1 PF07218.11 CDI85835.1 - 0.01 14.2 8.7 0.021 13.1 8.7 1.7 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SRCR PF00530.18 CDI85836.1 - 0.064 13.8 0.0 22 5.6 0.0 2.5 1 1 1 2 2 2 0 Scavenger receptor cysteine-rich domain polyprenyl_synt PF00348.17 CDI85839.1 - 1.8e-40 138.6 0.1 9.2e-34 116.6 0.2 4.1 3 1 0 3 3 3 3 Polyprenyl synthetase SHS2_Rpb7-N PF03876.17 CDI85840.1 - 1.1e-12 48.1 0.1 1.9e-12 47.4 0.1 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 CDI85840.1 - 1.3e-06 28.6 0.0 1.2e-05 25.5 0.0 2.1 2 0 0 2 2 2 1 S1 RNA binding domain PknH_C PF14032.6 CDI85840.1 - 0.0029 17.5 2.8 0.0037 17.2 2.8 1.2 1 0 0 1 1 1 1 PknH-like extracellular domain DRY_EERY PF09750.9 CDI85841.1 - 7.6e-09 35.9 1.2 7.6e-09 35.9 1.2 3.9 4 0 0 4 4 4 1 Alternative splicing regulator Surp PF01805.20 CDI85841.1 - 4.6e-07 29.7 4.1 3.5e-06 26.9 0.1 3.1 3 0 0 3 3 3 1 Surp module CAF1 PF04857.20 CDI85841.1 - 2 7.5 12.3 0.7 9.0 7.5 2.5 2 0 0 2 2 2 0 CAF1 family ribonuclease Presenilin PF01080.17 CDI85841.1 - 5.2 5.7 40.9 2.4 6.9 25.3 3.5 3 0 0 3 3 3 0 Presenilin LRR_4 PF12799.7 CDI85842.1 - 4.5e-19 68.2 18.9 3.4e-06 27.3 0.0 5.5 4 1 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI85842.1 - 1.2e-18 66.6 28.9 6.2e-09 35.5 1.8 4.6 1 1 6 7 7 7 6 Leucine rich repeat LRR_9 PF14580.6 CDI85842.1 - 2.7e-15 56.3 0.1 6.6e-08 32.3 0.0 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 CDI85842.1 - 0.002 18.0 18.8 0.09 12.9 0.1 6.4 6 1 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 CDI85842.1 - 0.0023 18.3 17.8 1.7 9.5 0.0 7.2 4 1 1 5 5 5 1 Leucine Rich Repeat DUF4381 PF14316.6 CDI85843.1 - 0.013 15.8 0.5 0.021 15.1 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Ribosomal_S19 PF00203.21 CDI85844.1 - 2.3e-30 104.3 0.1 3.1e-30 103.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 CS PF04969.16 CDI85845.1 - 6.6e-09 36.7 0.0 1.3e-08 35.8 0.0 1.5 1 0 0 1 1 1 1 CS domain Siah-Interact_N PF09032.11 CDI85845.1 - 1.3e-07 31.9 2.4 2.1e-06 27.9 0.4 2.6 2 0 0 2 2 2 1 Siah interacting protein, N terminal SGS PF05002.15 CDI85845.1 - 0.0001 22.3 1.0 0.0004 20.4 0.4 2.0 2 0 0 2 2 2 1 SGS domain DUF4795 PF16043.5 CDI85845.1 - 0.016 14.8 0.8 0.027 14.1 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) DUF4142 PF13628.6 CDI85845.1 - 0.11 12.8 0.5 0.21 11.8 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) CUE PF02845.16 CDI85846.1 - 0.045 13.5 0.3 0.18 11.5 0.0 2.2 2 0 0 2 2 2 0 CUE domain DUF4110 PF13422.6 CDI85847.1 - 3.3e-19 68.7 0.3 3.3e-19 68.7 0.3 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4110) Kelch_4 PF13418.6 CDI85847.1 - 7e-17 61.2 0.1 3.7e-10 39.7 0.0 3.0 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 CDI85847.1 - 1.9e-07 31.2 0.1 2.9e-05 24.2 0.0 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 CDI85847.1 - 1.6e-05 25.0 0.0 0.029 14.7 0.0 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 CDI85847.1 - 0.0029 17.5 0.1 3.6 7.7 0.0 2.7 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 CDI85847.1 - 0.097 12.7 0.1 0.62 10.1 0.0 2.3 2 0 0 2 2 2 0 Kelch motif Metallothio_11 PF02066.15 CDI85847.1 - 0.67 10.2 6.5 0.91 9.8 2.9 2.4 2 0 0 2 2 2 0 Metallothionein family 11 Nucleoporin_FG PF13634.6 CDI85850.1 - 7.1e-16 58.8 116.1 1.8e-06 28.7 37.6 4.9 1 1 2 3 3 3 2 Nucleoporin FG repeat region Mu-like_Pro PF10123.9 CDI85851.1 - 0.012 15.2 7.0 0.012 15.2 7.0 2.2 2 0 0 2 2 2 0 Mu-like prophage I protein Apt1 PF10351.9 CDI85851.1 - 2.3 7.0 24.8 0.059 12.2 7.3 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain PBP1_TM PF14812.6 CDI85853.1 - 0.3 11.5 8.8 0.34 11.3 8.8 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal EcoRI_methylase PF13651.6 CDI85853.1 - 0.38 9.9 8.0 0.45 9.7 8.0 1.0 1 0 0 1 1 1 0 Adenine-specific methyltransferase EcoRI SpoIIP PF07454.11 CDI85853.1 - 0.95 8.9 20.0 0.91 8.9 20.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Pex14_N PF04695.13 CDI85853.1 - 1.1 10.0 30.5 1.1 9.9 30.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM176 PF14851.6 CDI85853.1 - 1.3 8.7 11.0 1.5 8.5 11.0 1.1 1 0 0 1 1 1 0 FAM176 family Bcl-2_BAD PF10514.9 CDI85853.1 - 1.5 9.2 16.4 1.7 9.1 16.4 1.0 1 0 0 1 1 1 0 Pro-apoptotic Bcl-2 protein, BAD EFTUD2 PF16004.5 CDI85853.1 - 1.6 9.3 19.1 1.8 9.2 19.1 1.1 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Tim54 PF11711.8 CDI85853.1 - 1.6 7.4 17.6 1.6 7.4 17.6 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Gti1_Pac2 PF09729.9 CDI85853.1 - 1.9 8.5 17.2 2.2 8.4 17.2 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family CCDC53 PF10152.9 CDI85853.1 - 2.4 8.6 20.3 2.8 8.3 20.3 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex RR_TM4-6 PF06459.12 CDI85853.1 - 2.5 7.8 19.4 2.6 7.8 19.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI85853.1 - 2.7 6.7 24.6 2.7 6.7 24.6 1.0 1 0 0 1 1 1 0 Presenilin BORG_CEP PF14957.6 CDI85853.1 - 3.1 9.0 13.6 3.3 8.9 13.6 1.1 1 0 0 1 1 1 0 Cdc42 effector Connexin PF00029.19 CDI85853.1 - 3.4 7.4 17.3 3.3 7.4 17.3 1.0 1 0 0 1 1 1 0 Connexin FAM60A PF15396.6 CDI85853.1 - 4.3 7.3 15.0 4.2 7.3 15.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A AIF_C PF14721.6 CDI85853.1 - 4.4 7.7 14.8 5.2 7.4 14.8 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF5308 PF17233.2 CDI85853.1 - 4.7 7.4 18.4 5.1 7.3 18.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Peptidase_U57 PF05582.12 CDI85853.1 - 4.7 6.4 14.5 5.2 6.3 14.5 1.1 1 0 0 1 1 1 0 YabG peptidase U57 CPSF100_C PF13299.6 CDI85853.1 - 5.4 7.2 16.9 6.2 7.0 16.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF1764 PF08576.10 CDI85853.1 - 5.5 7.9 16.2 7.2 7.6 16.2 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) EIIBC-GUT_N PF03612.14 CDI85853.1 - 5.7 6.6 16.6 7.4 6.3 16.6 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus NPR3 PF03666.13 CDI85853.1 - 6.1 5.5 18.5 6.2 5.5 18.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TERB2 PF15101.6 CDI85853.1 - 6.1 6.8 27.1 7.1 6.6 27.1 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DDHD PF02862.17 CDI85853.1 - 6.2 6.9 19.1 6.2 6.9 19.1 1.1 1 0 0 1 1 1 0 DDHD domain EPL1 PF10513.9 CDI85853.1 - 6.4 7.1 21.0 8.9 6.7 21.0 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like CobT PF06213.12 CDI85853.1 - 6.5 6.1 29.0 6.8 6.0 29.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4569 PF15133.6 CDI85853.1 - 7.1 6.2 20.3 7.1 6.3 20.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) TFIIA PF03153.13 CDI85853.1 - 7.2 6.5 48.4 7.4 6.4 48.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SelP_N PF04592.14 CDI85853.1 - 7.4 5.9 26.7 8.2 5.8 26.7 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SLC12 PF03522.15 CDI85853.1 - 7.5 5.4 20.3 7.3 5.5 20.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CLN3 PF02487.17 CDI85853.1 - 7.7 5.4 16.6 8.4 5.3 16.6 1.0 1 0 0 1 1 1 0 CLN3 protein Peptidase_S64 PF08192.11 CDI85853.1 - 7.8 4.9 16.8 8.5 4.7 16.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF2828 PF11443.8 CDI85853.1 - 8 4.4 20.8 8.1 4.4 20.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Membralin PF09746.9 CDI85853.1 - 8 5.4 13.3 8.3 5.3 13.3 1.0 1 0 0 1 1 1 0 Tumour-associated protein Endostatin PF06482.11 CDI85853.1 - 8.5 5.7 20.8 8.7 5.7 20.8 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF3439 PF11921.8 CDI85854.1 - 0.4 10.7 12.2 5.4 7.0 11.8 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Presenilin PF01080.17 CDI85855.1 - 2e-05 23.5 0.5 2e-05 23.5 0.5 1.1 1 0 0 1 1 1 1 Presenilin EOS1 PF12326.8 CDI85855.1 - 0.021 14.8 0.0 0.021 14.8 0.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein SID-1_RNA_chan PF13965.6 CDI85855.1 - 0.1 11.0 0.0 0.1 11.0 0.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Tim54 PF11711.8 CDI85855.1 - 0.2 10.4 12.7 0.27 10.0 12.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DDHD PF02862.17 CDI85855.1 - 0.62 10.2 11.2 0.16 12.1 8.0 1.7 2 0 0 2 2 2 0 DDHD domain G0-G1_switch_2 PF15103.6 CDI85855.1 - 1.3 9.5 7.6 2.6 8.5 7.6 1.5 1 0 0 1 1 1 0 G0/G1 switch protein 2 Bacteriocin_IIc PF10439.9 CDI85855.1 - 3.6 7.8 35.0 3.3e+02 1.5 3.4 3.8 2 1 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide RskA PF10099.9 CDI85856.1 - 0.0019 18.5 59.5 0.037 14.3 0.0 5.4 1 1 3 5 5 5 1 Anti-sigma-K factor rskA BAF1_ABF1 PF04684.13 CDI85856.1 - 0.0031 16.6 25.5 0.0038 16.4 7.1 2.5 2 1 0 2 2 2 2 BAF1 / ABF1 chromatin reorganising factor DUF1761 PF08570.10 CDI85856.1 - 0.035 14.4 0.0 0.43 10.9 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1761) MobB PF03205.14 CDI85856.1 - 0.086 12.7 0.4 0.2 11.6 0.4 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Sin_N PF04801.13 CDI85856.1 - 0.55 9.4 35.4 0.011 15.0 7.1 2.3 2 0 0 2 2 2 0 Sin-like protein conserved region DUF5134 PF17197.4 CDI85856.1 - 0.81 9.6 19.6 0.04 13.8 3.8 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF5134) PAT1 PF09770.9 CDI85856.1 - 3.9 5.6 36.2 2.2 6.4 7.9 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 CDI85856.1 - 8.1 6.3 83.7 0.14 12.1 25.7 3.2 1 1 1 3 3 3 0 Transcription factor IIA, alpha/beta subunit BPD_transp_2 PF02653.16 CDI85856.1 - 8.8 5.4 19.1 2.1 7.5 3.6 3.6 3 1 0 3 3 3 0 Branched-chain amino acid transport system / permease component Apt1 PF10351.9 CDI85857.1 - 0.62 8.9 4.6 0.7 8.7 4.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Mannitol_dh_C PF08125.13 CDI85859.1 - 2.9 7.3 11.6 2.3 7.7 4.7 2.6 2 0 0 2 2 2 0 Mannitol dehydrogenase C-terminal domain Ldh_1_C PF02866.18 CDI85860.1 - 8.5e-18 64.8 0.0 1.7e-13 50.9 0.0 2.0 1 1 1 2 2 2 2 lactate/malate dehydrogenase, alpha/beta C-terminal domain Sigma70_r3 PF04539.16 CDI85860.1 - 0.053 13.6 0.6 0.92 9.7 0.1 2.2 2 0 0 2 2 2 0 Sigma-70 region 3 RskA PF10099.9 CDI85861.1 - 6.1e-05 23.4 4.2 6.1e-05 23.4 4.2 3.4 1 1 2 3 3 3 1 Anti-sigma-K factor rskA DUF4207 PF13904.6 CDI85861.1 - 0.099 12.3 83.5 1.4 8.6 65.3 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4207) SART-1 PF03343.13 CDI85861.1 - 1.2 7.6 47.4 1.7 7.1 47.4 1.2 1 0 0 1 1 1 0 SART-1 family SelP_N PF04592.14 CDI85861.1 - 1.4 8.2 45.9 0.22 10.9 35.6 2.4 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Presenilin PF01080.17 CDI85861.1 - 1.5 7.5 63.0 0.17 10.6 37.8 2.2 2 0 0 2 2 2 0 Presenilin SSP160 PF06933.11 CDI85861.1 - 2.7 6.1 21.0 4.3 5.4 21.0 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Utp14 PF04615.13 CDI85861.1 - 3 6.3 51.1 4.3 5.8 51.1 1.1 1 0 0 1 1 1 0 Utp14 protein Lin-8 PF03353.15 CDI85861.1 - 5.7 6.4 65.4 0.28 10.7 18.0 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist MIF PF01187.18 CDI85862.1 - 7.6e-15 55.2 0.1 7.7e-15 55.2 0.1 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Radial_spoke_3 PF06098.11 CDI85863.1 - 9.7e-16 57.9 0.6 5.4e-15 55.4 0.6 1.8 1 1 0 1 1 1 1 Radial spoke protein 3 Spt20 PF12090.8 CDI85863.1 - 0.032 13.9 4.3 0.037 13.7 4.3 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI85863.1 - 1.2 9.0 12.0 1.5 8.7 12.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI85863.1 - 3.4 7.8 14.9 6.7 6.9 14.8 1.6 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF390 PF04094.14 CDI85865.1 - 0.033 12.5 1.8 0.038 12.3 1.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF390) VHS PF00790.19 CDI85865.1 - 0.08 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 VHS domain Macoilin PF09726.9 CDI85866.1 - 0.018 13.6 23.1 0.022 13.3 23.1 1.1 1 0 0 1 1 1 0 Macoilin family Exonuc_VII_L PF02601.15 CDI85866.1 - 0.062 12.9 33.5 0.099 12.2 33.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fmp27_WPPW PF10359.9 CDI85866.1 - 0.73 8.6 32.0 1.1 8.0 32.0 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain V_ATPase_I PF01496.19 CDI85866.1 - 0.82 7.5 29.3 1.1 7.1 29.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Caldesmon PF02029.15 CDI85866.1 - 0.88 8.3 21.9 1.1 8.0 21.9 1.2 1 0 0 1 1 1 0 Caldesmon DUF4407 PF14362.6 CDI85866.1 - 1.5 8.1 30.8 2.7 7.2 30.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PIN_8 PF18476.1 CDI85866.1 - 1.9 8.3 17.5 2.8 7.7 17.5 1.2 1 0 0 1 1 1 0 PIN like domain Spc7 PF08317.11 CDI85866.1 - 2 7.2 47.9 4.1 6.2 47.9 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 CDI85866.1 - 2 8.9 56.9 7.9 7.0 56.8 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4776 PF16003.5 CDI85866.1 - 2.9 6.8 20.3 5.1 6.0 20.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) DUF3552 PF12072.8 CDI85866.1 - 3 7.2 51.7 1.9 7.9 28.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Syntaxin-6_N PF09177.11 CDI85866.1 - 3 8.4 21.9 7.7 7.1 21.9 1.7 1 0 0 1 1 1 0 Syntaxin 6, N-terminal WXG100 PF06013.12 CDI85866.1 - 3.9 7.8 52.6 1.9 8.8 14.3 3.6 2 1 2 4 4 4 0 Proteins of 100 residues with WXG AAA_11 PF13086.6 CDI85866.1 - 5.1 6.8 23.4 8.7 6.0 23.4 1.4 1 0 0 1 1 1 0 AAA domain Neur_chan_memb PF02932.16 CDI85866.1 - 5.2 7.1 14.9 9.9 6.1 14.9 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ZapB PF06005.12 CDI85866.1 - 5.8 7.4 71.3 3.4 8.2 23.0 3.5 1 1 2 3 3 3 0 Cell division protein ZapB Atg14 PF10186.9 CDI85866.1 - 5.9 5.9 36.8 11 5.0 36.8 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Golgin_A5 PF09787.9 CDI85866.1 - 9 5.7 47.5 13 5.1 47.5 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 SR-25 PF10500.9 CDI85867.1 - 1.6 8.3 64.9 0.19 11.3 27.5 3.2 1 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein Utp14 PF04615.13 CDI85867.1 - 1.8 7.1 30.8 2.2 6.8 30.8 1.0 1 0 0 1 1 1 0 Utp14 protein Macoilin PF09726.9 CDI85869.1 - 0.0024 16.5 30.6 0.0029 16.3 30.6 1.0 1 0 0 1 1 1 1 Macoilin family Serinc PF03348.15 CDI85869.1 - 0.014 14.4 12.8 0.02 13.8 12.8 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) ADP_ribosyl_GH PF03747.14 CDI85869.1 - 0.02 14.6 2.1 0.023 14.4 2.1 1.2 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase eIF-3_zeta PF05091.12 CDI85869.1 - 0.033 13.2 25.9 0.037 13.0 25.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3450 PF11932.8 CDI85869.1 - 0.044 13.1 34.0 0.052 12.8 34.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DDRGK PF09756.9 CDI85869.1 - 0.045 13.3 30.5 0.055 13.1 30.5 1.1 1 0 0 1 1 1 0 DDRGK domain TFIIA PF03153.13 CDI85869.1 - 0.051 13.6 54.1 0.076 13.0 54.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CytochromB561_N PF09786.9 CDI85869.1 - 0.063 12.3 19.1 0.072 12.1 19.1 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal Miga PF10265.9 CDI85869.1 - 0.077 12.0 21.3 0.098 11.6 21.3 1.1 1 0 0 1 1 1 0 Mitoguardin TRAP_alpha PF03896.16 CDI85869.1 - 0.09 12.0 12.9 0.11 11.6 12.9 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit GAGA_bind PF06217.12 CDI85869.1 - 0.099 12.9 18.4 0.1 12.9 18.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF3295 PF11702.8 CDI85869.1 - 0.11 11.9 31.4 0.13 11.6 31.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) PIEZO PF15917.5 CDI85869.1 - 0.11 12.0 23.6 0.14 11.6 23.6 1.3 1 0 0 1 1 1 0 Piezo DUF4746 PF15928.5 CDI85869.1 - 0.11 11.8 16.3 0.13 11.6 16.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CDC45 PF02724.14 CDI85869.1 - 0.15 10.3 28.4 0.19 10.0 28.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF21 PF01595.20 CDI85869.1 - 0.23 11.2 1.0 0.42 10.3 1.0 1.7 1 1 0 1 1 1 0 Cyclin M transmembrane N-terminal domain DUF2828 PF11443.8 CDI85869.1 - 0.29 9.2 21.3 0.32 9.0 21.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MMR1 PF08505.10 CDI85869.1 - 0.31 11.3 37.2 0.49 10.6 37.2 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein PAT1 PF09770.9 CDI85869.1 - 0.33 9.2 42.6 0.39 8.9 42.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Draxin PF15550.6 CDI85869.1 - 0.33 10.8 20.1 0.41 10.5 20.1 1.0 1 0 0 1 1 1 0 Draxin Peptidase_S15 PF02129.18 CDI85869.1 - 0.46 10.0 14.8 0.56 9.7 14.8 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Lin-8 PF03353.15 CDI85869.1 - 0.51 9.8 38.0 0.64 9.5 38.0 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MDM10 PF12519.8 CDI85869.1 - 0.76 8.6 22.1 0.97 8.2 22.1 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 GREB1 PF15782.5 CDI85869.1 - 0.82 6.7 35.4 0.96 6.5 35.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LMBR1 PF04791.16 CDI85869.1 - 0.84 8.5 11.3 1.1 8.1 11.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein PNISR PF15996.5 CDI85869.1 - 0.86 9.8 32.5 1.4 9.2 32.5 1.4 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Spc7_N PF15402.6 CDI85869.1 - 1.2 7.3 28.3 1.4 7.0 28.3 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 GBP_C PF02841.14 CDI85869.1 - 1.6 8.1 36.5 2.1 7.7 36.5 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Plasmodium_Vir PF05795.11 CDI85869.1 - 1.6 8.0 20.3 2.3 7.5 20.3 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Apt1 PF10351.9 CDI85869.1 - 1.7 7.4 26.8 2.3 7.0 26.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SLC12 PF03522.15 CDI85869.1 - 1.7 7.6 30.6 2.4 7.1 30.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 SMYLE_N PF18615.1 CDI85869.1 - 1.8 8.0 23.2 2.4 7.7 23.2 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Asp-B-Hydro_N PF05279.11 CDI85869.1 - 1.8 8.5 22.1 2.2 8.3 22.1 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Bud13 PF09736.9 CDI85869.1 - 2.1 8.8 28.0 3.3 8.1 28.0 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex DUF572 PF04502.13 CDI85869.1 - 2.1 7.9 29.2 2.9 7.4 29.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Utp14 PF04615.13 CDI85869.1 - 2.2 6.7 35.1 2.7 6.5 35.1 1.0 1 0 0 1 1 1 0 Utp14 protein SPX PF03105.19 CDI85869.1 - 3 7.7 30.3 3.6 7.4 30.3 1.1 1 0 0 1 1 1 0 SPX domain AMP-binding PF00501.28 CDI85869.1 - 3.5 6.1 7.6 4.1 5.9 7.6 1.2 1 0 0 1 1 1 0 AMP-binding enzyme TT_ORF1 PF02956.14 CDI85869.1 - 3.8 6.1 20.4 5.5 5.6 20.4 1.3 1 0 0 1 1 1 0 TT viral orf 1 PMSI1 PF15322.6 CDI85869.1 - 3.8 6.9 21.5 6.3 6.2 21.5 1.4 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative RRP36 PF06102.12 CDI85869.1 - 3.9 7.4 31.6 6.2 6.8 31.6 1.3 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 DUF4045 PF13254.6 CDI85869.1 - 3.9 7.0 33.4 5.6 6.5 33.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Hamartin PF04388.12 CDI85869.1 - 4.1 6.0 26.6 5.9 5.4 26.6 1.3 1 0 0 1 1 1 0 Hamartin protein PAP1 PF08601.10 CDI85869.1 - 4.4 6.9 33.2 5.4 6.6 33.2 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Sin_N PF04801.13 CDI85869.1 - 4.6 6.3 41.1 5.7 6.0 41.1 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region FliP PF00813.20 CDI85869.1 - 5 7.0 10.4 7.4 6.4 10.4 1.4 1 0 0 1 1 1 0 FliP family SOBP PF15279.6 CDI85869.1 - 6.3 7.3 28.3 8.6 6.9 28.3 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein NST1 PF13945.6 CDI85869.1 - 7.1 6.7 45.1 14 5.8 45.1 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF4638 PF15472.6 CDI85869.1 - 7.1 6.3 24.9 9.3 5.9 24.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Endomucin PF07010.12 CDI85869.1 - 8.2 6.3 32.4 10 6.0 32.4 1.0 1 0 0 1 1 1 0 Endomucin DUF3292 PF11696.8 CDI85869.1 - 8.5 4.6 17.5 11 4.2 17.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF2232 PF09991.9 CDI85869.1 - 9.3 5.3 6.9 15 4.7 6.9 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DUF913 PF06025.12 CDI85870.1 - 0.031 13.3 10.6 0.038 13.0 10.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hid1 PF12722.7 CDI85870.1 - 0.037 12.2 19.8 0.036 12.2 19.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.12 CDI85870.1 - 0.041 13.7 24.5 0.049 13.5 24.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Endostatin PF06482.11 CDI85870.1 - 0.05 13.1 21.3 0.058 12.9 21.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Lin-8 PF03353.15 CDI85870.1 - 0.063 12.8 31.8 0.075 12.6 31.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF3527 PF12043.8 CDI85870.1 - 0.07 12.7 20.7 0.078 12.5 20.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) PA26 PF04636.13 CDI85870.1 - 0.073 12.0 15.1 0.081 11.8 15.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Zip PF02535.22 CDI85870.1 - 0.13 11.5 11.1 0.14 11.3 11.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Otopetrin PF03189.13 CDI85870.1 - 0.15 10.8 11.7 0.17 10.7 11.7 1.1 1 0 0 1 1 1 0 Otopetrin SID-1_RNA_chan PF13965.6 CDI85870.1 - 0.15 10.4 10.4 0.23 9.8 10.4 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2052 PF09747.9 CDI85870.1 - 0.27 11.3 26.3 0.32 11.1 26.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4045 PF13254.6 CDI85870.1 - 0.45 10.1 22.2 0.52 9.9 22.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF3807 PF12720.7 CDI85870.1 - 0.55 10.5 34.9 0.74 10.1 34.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) HCO3_cotransp PF00955.21 CDI85870.1 - 0.63 8.8 10.8 0.69 8.7 10.8 1.1 1 0 0 1 1 1 0 HCO3- transporter family SLC12 PF03522.15 CDI85870.1 - 0.7 8.8 29.2 0.82 8.6 29.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 CDI85870.1 - 0.74 8.0 21.3 0.88 7.8 21.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI85870.1 - 0.77 8.5 34.0 0.93 8.2 34.0 1.1 1 0 0 1 1 1 0 Presenilin Radical_SAM_N PF08497.10 CDI85870.1 - 0.89 8.7 13.0 1.1 8.4 13.0 1.0 1 0 0 1 1 1 0 Radical SAM N-terminal eIF-3_zeta PF05091.12 CDI85870.1 - 0.92 8.4 32.7 1.3 7.9 32.7 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Band_3_cyto PF07565.13 CDI85870.1 - 1.1 9.0 24.9 1.8 8.3 24.9 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Peroxin-3 PF04882.12 CDI85870.1 - 1.1 8.1 26.5 1.3 7.9 26.5 1.0 1 0 0 1 1 1 0 Peroxin-3 TCP PF03634.13 CDI85870.1 - 1.5 9.4 24.9 2 9.0 24.9 1.2 1 0 0 1 1 1 0 TCP family transcription factor Hamartin PF04388.12 CDI85870.1 - 1.7 7.3 24.7 1.9 7.1 24.7 1.0 1 0 0 1 1 1 0 Hamartin protein Gti1_Pac2 PF09729.9 CDI85870.1 - 1.8 8.6 22.0 2.6 8.1 22.0 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Cellulose_synt PF03552.14 CDI85870.1 - 1.9 6.9 8.6 2.4 6.6 8.6 1.2 1 0 0 1 1 1 0 Cellulose synthase BPL_N PF09825.9 CDI85870.1 - 1.9 7.4 14.8 2.3 7.2 14.8 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Allexi_40kDa PF05549.11 CDI85870.1 - 2 7.9 16.4 2.2 7.7 16.4 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF2828 PF11443.8 CDI85870.1 - 2 6.4 25.3 2.6 6.1 25.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Rtf2 PF04641.12 CDI85870.1 - 2.4 7.5 23.2 2.9 7.2 23.2 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger SARAF PF06682.12 CDI85870.1 - 2.5 7.6 24.6 3.6 7.2 24.6 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF572 PF04502.13 CDI85870.1 - 2.8 7.5 24.1 3.4 7.2 24.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) O-antigen_lig PF13425.6 CDI85870.1 - 3 6.5 11.1 3.4 6.4 11.1 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein FAM70 PF14967.6 CDI85870.1 - 3.3 7.1 12.2 3.4 7.0 12.2 1.1 1 0 0 1 1 1 0 FAM70 protein NARP1 PF12569.8 CDI85870.1 - 3.7 6.3 23.8 4.7 6.0 23.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 NPR3 PF03666.13 CDI85870.1 - 4 6.1 24.7 4.9 5.8 24.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4746 PF15928.5 CDI85870.1 - 4.2 6.7 20.5 5.5 6.3 20.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SUFU_C PF12470.8 CDI85870.1 - 4.3 7.3 18.7 5.7 6.9 18.7 1.1 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain FAM60A PF15396.6 CDI85870.1 - 4.4 7.3 23.5 5.4 7.0 23.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A V_ATPase_I PF01496.19 CDI85870.1 - 4.5 5.1 25.9 6 4.6 25.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GAGA_bind PF06217.12 CDI85870.1 - 4.7 7.4 22.3 5.6 7.2 22.3 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family CCSAP PF15748.5 CDI85870.1 - 5.7 7.0 31.8 6.8 6.8 31.8 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Het-C PF07217.11 CDI85870.1 - 6.1 5.2 18.3 8.7 4.7 18.3 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF1387 PF07139.11 CDI85870.1 - 6.3 6.4 27.5 7.9 6.1 27.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) FapA PF03961.13 CDI85870.1 - 6.8 5.2 17.5 7.7 5.0 17.5 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Velvet PF11754.8 CDI85870.1 - 6.8 6.6 26.4 9.8 6.0 26.4 1.2 1 0 0 1 1 1 0 Velvet factor YhfC PF10086.9 CDI85870.1 - 8.1 5.7 17.8 1.9 7.8 4.7 2.1 1 1 1 2 2 2 0 YhfC intramembrane metalloprotease PAT1 PF09770.9 CDI85870.1 - 9.8 4.3 49.4 11 4.1 49.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PBP1_TM PF14812.6 CDI85871.1 - 0.031 14.6 2.7 0.031 14.6 2.7 2.7 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SDA1 PF05285.12 CDI85871.1 - 1.3 8.4 30.2 1.6 8.1 30.2 1.0 1 0 0 1 1 1 0 SDA1 SLC12 PF03522.15 CDI85871.1 - 2.4 7.1 36.2 3.1 6.7 36.2 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF3807 PF12720.7 CDI85871.1 - 6.8 6.9 45.7 1.5 9.0 16.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) K_channel_TID PF07941.11 CDI85873.1 - 0.0054 17.2 6.9 0.0054 17.2 6.9 4.2 3 2 0 3 3 3 1 Potassium channel Kv1.4 tandem inactivation domain DUF4484 PF14831.6 CDI85873.1 - 0.2 11.7 23.3 0.23 11.5 23.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) PPP4R2 PF09184.11 CDI85873.1 - 0.4 10.2 17.0 0.45 10.1 17.0 1.1 1 0 0 1 1 1 0 PPP4R2 KAsynt_C_assoc PF16197.5 CDI85873.1 - 0.65 10.5 11.9 0.035 14.6 4.0 2.1 1 1 1 2 2 2 0 Ketoacyl-synthetase C-terminal extension CDC27 PF09507.10 CDI85873.1 - 1.3 8.3 28.9 1.5 8.2 28.9 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 YppG PF14179.6 CDI85873.1 - 2 9.1 44.5 0.035 14.8 27.8 2.4 2 0 0 2 2 2 0 YppG-like protein SYF2 PF08231.12 CDI85873.1 - 5.1 7.5 23.4 6.6 7.1 23.4 1.2 1 0 0 1 1 1 0 SYF2 splicing factor Tyrosinase PF00264.20 CDI85873.1 - 5.2 7.3 13.9 6.3 7.0 13.9 1.1 1 0 0 1 1 1 0 Common central domain of tyrosinase Activator_LAG-3 PF11498.8 CDI85873.1 - 5.9 5.7 81.4 6.7 5.6 81.4 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Peptidase_M56 PF05569.11 CDI85873.1 - 9.6 5.3 8.2 12 4.9 8.2 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 START PF01852.19 CDI85877.1 - 1.7e-18 66.8 0.0 2e-18 66.6 0.0 1.0 1 0 0 1 1 1 1 START domain DUF3074 PF11274.8 CDI85877.1 - 0.011 15.8 0.0 0.036 14.0 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) CbtA_toxin PF06755.12 CDI85877.1 - 0.056 13.5 0.0 0.099 12.7 0.0 1.4 1 0 0 1 1 1 0 CbtA_toxin of type IV toxin-antitoxin system CDC45 PF02724.14 CDI85878.1 - 6.9 4.8 36.5 8.5 4.5 36.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Spt20 PF12090.8 CDI85879.1 - 1.6 8.3 5.5 3 7.4 5.5 1.4 1 0 0 1 1 1 0 Spt20 family DUF1053 PF06327.14 CDI85880.1 - 0.007 16.9 3.0 0.2 12.2 0.1 2.5 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1053) BBP1_N PF15271.6 CDI85880.1 - 0.022 15.6 3.4 0.069 13.9 0.3 2.2 2 0 0 2 2 2 0 Spindle pole body component BBP1, Mps2-binding protein DUF5345 PF17280.2 CDI85880.1 - 0.055 13.5 13.6 0.13 12.3 1.4 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Pet20 PF08692.10 CDI85880.1 - 0.15 12.8 0.7 28 5.4 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial protein Pet20 DivIC PF04977.15 CDI85880.1 - 0.41 10.4 20.9 0.75 9.6 2.9 2.5 2 0 0 2 2 2 0 Septum formation initiator XK-related PF09815.9 CDI85880.1 - 1.3 8.0 4.1 18 4.3 0.1 2.2 2 0 0 2 2 2 0 XK-related protein Spt20 PF12090.8 CDI85880.1 - 1.9 8.1 42.3 0.1 12.2 14.2 3.0 4 0 0 4 4 4 0 Spt20 family AAA_23 PF13476.6 CDI85880.1 - 5 7.6 8.6 19 5.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain SAPS PF04499.15 CDI85881.1 - 1.6 7.4 29.5 1.9 7.2 29.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Raftlin PF15250.6 CDI85881.1 - 3.6 6.2 30.5 3.7 6.2 30.5 1.0 1 0 0 1 1 1 0 Raftlin DUF4045 PF13254.6 CDI85881.1 - 4.7 6.8 35.1 5.2 6.6 35.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) ALMT PF11744.8 CDI85881.1 - 5.2 5.8 31.9 6.6 5.4 31.9 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4207 PF13904.6 CDI85882.1 - 0.0068 16.1 13.5 0.0068 16.1 13.5 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4207) Cyt_bd_oxida_II PF02322.15 CDI85882.1 - 0.94 8.8 7.6 1.4 8.2 7.6 1.2 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II HBB PF06777.11 CDI85883.1 - 4e-10 39.7 8.9 3.7e-08 33.3 0.1 2.1 1 1 1 2 2 2 1 Helical and beta-bridge domain Pex14_N PF04695.13 CDI85883.1 - 0.00017 22.3 16.3 0.00019 22.1 16.3 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region MTP18 PF10558.9 CDI85883.1 - 0.0011 18.9 4.6 0.0013 18.7 4.6 1.3 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) Tim54 PF11711.8 CDI85883.1 - 0.0022 16.9 10.1 0.0026 16.6 10.1 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Hydin_ADK PF17213.3 CDI85883.1 - 0.0039 17.5 9.2 0.0048 17.2 9.2 1.1 1 0 0 1 1 1 1 Hydin Adenylate kinase-like domain eIF3_subunit PF08597.10 CDI85883.1 - 0.0043 17.0 11.2 0.0049 16.8 11.2 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit DDHD PF02862.17 CDI85883.1 - 0.0053 16.9 9.8 0.0055 16.9 9.8 1.1 1 0 0 1 1 1 1 DDHD domain SGIII PF15467.6 CDI85883.1 - 0.0075 15.6 11.2 0.012 15.0 11.2 1.3 1 1 0 1 1 1 1 Secretogranin-3 EPL1 PF10513.9 CDI85883.1 - 0.0079 16.6 10.3 0.01 16.2 10.3 1.3 1 0 0 1 1 1 1 Enhancer of polycomb-like Het-C PF07217.11 CDI85883.1 - 0.0086 14.7 10.2 0.0088 14.6 10.2 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C V_ATPase_I PF01496.19 CDI85883.1 - 0.012 13.5 11.5 0.012 13.6 11.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 CDI85883.1 - 0.013 15.3 6.0 0.012 15.3 6.0 1.2 1 0 0 1 1 1 0 Connexin DUF3464 PF11947.8 CDI85883.1 - 0.018 14.8 9.0 0.021 14.6 9.0 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF4471 PF14740.6 CDI85883.1 - 0.022 14.0 7.8 0.022 14.0 7.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) MDM10 PF12519.8 CDI85883.1 - 0.022 13.6 7.7 0.025 13.5 7.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF913 PF06025.12 CDI85883.1 - 0.023 13.7 4.7 0.024 13.7 4.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PPL5 PF18168.1 CDI85883.1 - 0.026 13.8 5.7 0.029 13.7 5.7 1.1 1 0 0 1 1 1 0 Prim-pol family 5 RP-C_C PF11800.8 CDI85883.1 - 0.027 14.6 11.9 0.03 14.4 11.9 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region CobT PF06213.12 CDI85883.1 - 0.029 13.7 25.8 0.042 13.2 25.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4638 PF15472.6 CDI85883.1 - 0.03 14.0 12.2 0.036 13.8 12.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Band_3_cyto PF07565.13 CDI85883.1 - 0.031 14.1 9.8 0.033 14.0 9.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SpoIIP PF07454.11 CDI85883.1 - 0.032 13.7 12.3 0.033 13.6 12.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Plasmodium_Vir PF05795.11 CDI85883.1 - 0.034 13.6 3.3 0.04 13.3 3.3 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CLN3 PF02487.17 CDI85883.1 - 0.042 12.9 6.6 0.043 12.9 6.6 1.1 1 0 0 1 1 1 0 CLN3 protein DUF719 PF05334.13 CDI85883.1 - 0.052 13.8 9.5 0.069 13.3 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF719) TFIIA PF03153.13 CDI85883.1 - 0.055 13.5 36.0 0.061 13.3 36.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4050 PF13259.6 CDI85883.1 - 0.073 13.4 12.5 0.091 13.1 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) OATP PF03137.20 CDI85883.1 - 0.082 11.2 3.9 0.088 11.1 3.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Pet20 PF08692.10 CDI85883.1 - 0.086 13.6 2.4 0.11 13.2 2.4 1.3 1 0 0 1 1 1 0 Mitochondrial protein Pet20 EOS1 PF12326.8 CDI85883.1 - 0.088 12.7 8.1 0.14 12.0 8.1 1.4 1 0 0 1 1 1 0 N-glycosylation protein Kei1 PF08552.11 CDI85883.1 - 0.089 12.7 5.1 0.1 12.4 5.1 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF2235 PF09994.9 CDI85883.1 - 0.09 12.1 5.1 0.12 11.7 5.1 1.3 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) Jak1_Phl PF17887.1 CDI85883.1 - 0.11 12.4 11.2 0.14 12.1 11.2 1.1 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain NACHT_N PF17100.5 CDI85883.1 - 0.15 11.9 13.2 0.17 11.7 13.2 1.2 1 0 0 1 1 1 0 N-terminal domain of NWD NACHT-NTPase Pkinase_fungal PF17667.1 CDI85883.1 - 0.17 10.6 6.8 0.19 10.5 6.8 1.0 1 0 0 1 1 1 0 Fungal protein kinase Presenilin PF01080.17 CDI85883.1 - 0.17 10.6 18.7 0.2 10.4 18.7 1.1 1 0 0 1 1 1 0 Presenilin MRP-S31 PF15433.6 CDI85883.1 - 0.21 11.2 16.1 0.23 11.1 16.1 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 eIF-3_zeta PF05091.12 CDI85883.1 - 0.21 10.5 21.3 0.24 10.3 21.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_C58 PF03543.14 CDI85883.1 - 0.26 10.9 16.2 0.31 10.7 16.2 1.1 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen Neur_chan_memb PF02932.16 CDI85883.1 - 0.28 11.2 11.3 0.3 11.1 11.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TERB2 PF15101.6 CDI85883.1 - 0.29 11.1 19.6 0.4 10.7 19.6 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF2126 PF09899.9 CDI85883.1 - 0.3 9.1 7.7 0.31 9.1 7.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CPSF100_C PF13299.6 CDI85883.1 - 0.35 11.1 11.7 0.42 10.8 11.7 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Ndc1_Nup PF09531.10 CDI85883.1 - 0.37 9.4 13.3 0.38 9.4 13.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 CDI85883.1 - 0.39 8.9 27.7 0.42 8.8 27.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Gti1_Pac2 PF09729.9 CDI85883.1 - 0.39 10.8 10.9 0.48 10.5 10.9 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family PIEZO PF15917.5 CDI85883.1 - 0.45 10.0 19.9 0.54 9.7 19.9 1.1 1 0 0 1 1 1 0 Piezo MPM1 PF17234.2 CDI85883.1 - 0.6 10.4 16.0 0.85 9.9 16.0 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 CCDC53 PF10152.9 CDI85883.1 - 0.61 10.5 15.4 0.8 10.1 15.4 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex VIT1 PF01988.19 CDI85883.1 - 0.64 9.9 3.5 0.82 9.5 3.5 1.3 1 0 0 1 1 1 0 VIT family DUF775 PF05603.12 CDI85883.1 - 0.67 9.5 15.0 1 8.9 15.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF775) DUF3408 PF11888.8 CDI85883.1 - 0.71 10.0 16.0 1.2 9.3 16.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) ABC2_membrane_2 PF12679.7 CDI85883.1 - 0.71 9.1 3.5 0.81 8.9 3.5 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF1980 PF09323.10 CDI85883.1 - 0.72 9.7 14.9 1.1 9.2 14.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) ALMT PF11744.8 CDI85883.1 - 0.73 8.6 11.5 0.77 8.5 11.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Otopetrin PF03189.13 CDI85883.1 - 0.78 8.5 5.1 0.75 8.5 5.1 1.1 1 0 0 1 1 1 0 Otopetrin Peroxin-13_N PF04088.13 CDI85883.1 - 0.78 10.0 11.4 0.13 12.6 7.7 1.6 2 0 0 2 2 1 0 Peroxin 13, N-terminal region Scs3p PF10261.9 CDI85883.1 - 0.87 9.0 2.6 0.91 9.0 2.6 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM SLC12 PF03522.15 CDI85883.1 - 0.92 8.5 16.2 0.98 8.4 16.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 HCO3_cotransp PF00955.21 CDI85883.1 - 0.97 8.2 3.1 0.94 8.2 3.1 1.1 1 0 0 1 1 1 0 HCO3- transporter family MMR1 PF08505.10 CDI85883.1 - 0.98 9.7 20.1 1.1 9.4 20.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein NARP1 PF12569.8 CDI85883.1 - 0.98 8.3 15.1 1.1 8.1 15.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 MDM31_MDM32 PF08118.11 CDI85883.1 - 1.1 7.9 13.8 1.4 7.5 13.8 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins FTZ PF03867.14 CDI85883.1 - 1.2 8.7 14.6 1.6 8.2 14.6 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region Peptidase_U57 PF05582.12 CDI85883.1 - 1.2 8.4 9.8 1.7 7.9 9.8 1.3 1 0 0 1 1 1 0 YabG peptidase U57 Cellulose_synt PF03552.14 CDI85883.1 - 1.2 7.5 3.8 1.1 7.7 3.8 1.0 1 0 0 1 1 1 0 Cellulose synthase CTU2 PF10288.9 CDI85883.1 - 1.4 9.2 13.4 1.9 8.8 13.4 1.2 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Senescence_reg PF04520.13 CDI85883.1 - 1.4 9.8 12.4 1.7 9.5 12.4 1.1 1 0 0 1 1 1 0 Senescence regulator RR_TM4-6 PF06459.12 CDI85883.1 - 1.5 8.6 18.2 2.3 8.0 18.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Exonuc_VII_L PF02601.15 CDI85883.1 - 1.5 8.3 18.3 1.6 8.3 18.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF853 PF05872.12 CDI85883.1 - 1.6 7.3 13.4 1.8 7.1 13.4 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Miga PF10265.9 CDI85883.1 - 1.6 7.6 11.1 1.8 7.4 11.1 1.0 1 0 0 1 1 1 0 Mitoguardin DUF3801 PF12687.7 CDI85883.1 - 1.6 8.7 20.8 2 8.5 20.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) Zip PF02535.22 CDI85883.1 - 1.6 7.8 7.2 1.8 7.7 7.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 CDI85883.1 - 1.6 7.4 15.0 1.9 7.2 15.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PIP5K PF01504.18 CDI85883.1 - 1.7 7.8 13.3 2.2 7.5 13.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Paramyxo_ncap PF00973.19 CDI85883.1 - 1.7 7.5 9.7 1.7 7.5 9.7 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein MMU163 PF17119.5 CDI85883.1 - 1.7 7.7 7.1 2 7.5 7.1 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Asparaginase_2 PF01112.18 CDI85883.1 - 1.9 7.5 7.2 2.1 7.3 7.2 1.2 1 0 0 1 1 1 0 Asparaginase Pap_E4 PF02711.14 CDI85883.1 - 1.9 9.5 15.0 3.2 8.8 15.0 1.3 1 0 0 1 1 1 0 E4 protein DUF4746 PF15928.5 CDI85883.1 - 2 7.8 11.0 2.3 7.6 11.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Pannexin_like PF12534.8 CDI85883.1 - 2.2 7.3 10.3 5 6.1 10.6 1.5 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 Nucleoside_tran PF01733.18 CDI85883.1 - 2.6 7.3 5.0 3.2 7.0 5.0 1.1 1 0 0 1 1 1 0 Nucleoside transporter PepSY_TM PF03929.16 CDI85883.1 - 2.8 7.5 9.2 3.2 7.3 9.2 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Paf1 PF03985.13 CDI85883.1 - 3 6.8 23.6 3.8 6.4 23.6 1.1 1 0 0 1 1 1 0 Paf1 CDC45 PF02724.14 CDI85883.1 - 3 6.0 16.3 3.3 5.9 16.3 1.0 1 0 0 1 1 1 0 CDC45-like protein NEMP PF10225.9 CDI85883.1 - 3 7.4 11.1 4.3 6.9 11.1 1.2 1 0 0 1 1 1 0 NEMP family CSG2 PF16965.5 CDI85883.1 - 3.4 6.5 9.3 3.9 6.3 9.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator GREB1 PF15782.5 CDI85883.1 - 3.5 4.6 15.4 3.6 4.6 15.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer GTSE1_N PF15259.6 CDI85883.1 - 3.6 7.8 16.6 9.3 6.4 17.1 1.5 2 0 0 2 2 1 0 G-2 and S-phase expressed 1 EIIBC-GUT_N PF03612.14 CDI85883.1 - 3.8 7.2 13.6 4.7 6.9 13.6 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus BORG_CEP PF14957.6 CDI85883.1 - 3.8 8.7 12.6 4.9 8.3 12.6 1.1 1 0 0 1 1 1 0 Cdc42 effector Rtf2 PF04641.12 CDI85883.1 - 3.9 6.8 15.8 4.6 6.5 15.8 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Hid1 PF12722.7 CDI85883.1 - 4 5.5 16.9 4.5 5.3 16.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ATAD4 PF15321.6 CDI85883.1 - 4.3 8.8 12.6 6.4 8.2 12.6 1.3 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 DUF2828 PF11443.8 CDI85883.1 - 4.4 5.3 16.1 5.1 5.1 16.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) FUSC PF04632.12 CDI85883.1 - 4.6 5.7 12.0 4.9 5.6 12.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Rrn6 PF10214.9 CDI85883.1 - 5.9 5.3 26.0 6.8 5.1 26.0 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor UPF0560 PF10577.9 CDI85883.1 - 6 5.2 24.9 7.3 5.0 24.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 LptF_LptG PF03739.14 CDI85883.1 - 6.1 5.6 6.1 6.6 5.5 6.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG SPATA3 PF15662.5 CDI85883.1 - 7.3 7.2 16.4 9.2 6.8 16.4 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family SID-1_RNA_chan PF13965.6 CDI85883.1 - 7.9 4.7 8.6 8.6 4.6 8.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Folate_carrier PF01770.18 CDI85883.1 - 8.1 5.1 8.7 11 4.7 8.7 1.2 1 0 0 1 1 1 0 Reduced folate carrier Baculo_PP31 PF05311.11 CDI85883.1 - 9.8 5.6 15.6 14 5.0 15.6 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) SR-25 PF10500.9 CDI85885.1 - 0.0061 16.2 2.5 0.0084 15.7 2.5 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CCSAP PF15748.5 CDI85885.1 - 0.57 10.3 10.0 0.22 11.7 7.5 1.6 1 1 0 1 1 1 0 Centriole, cilia and spindle-associated DUF979 PF06166.12 CDI85886.1 - 0.0013 18.0 1.8 0.0014 17.9 1.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF979) Spt20 PF12090.8 CDI85886.1 - 0.049 13.2 7.9 0.058 13.0 7.9 1.1 1 0 0 1 1 1 0 Spt20 family ChaC PF04752.12 CDI85886.1 - 0.068 13.2 0.8 0.079 13.0 0.8 1.1 1 0 0 1 1 1 0 ChaC-like protein CDK2AP PF09806.9 CDI85886.1 - 0.2 11.7 11.5 0.27 11.2 11.5 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein TFIIA PF03153.13 CDI85886.1 - 0.36 10.8 10.9 0.42 10.6 10.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1754 PF08555.10 CDI85887.1 - 0.11 13.3 35.5 0.13 13.0 35.5 1.1 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) Pox_Ag35 PF03286.14 CDI85887.1 - 1.5 8.5 29.9 1.9 8.3 29.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein BUD22 PF09073.10 CDI85887.1 - 1.8 7.8 36.8 1.8 7.8 36.8 1.0 1 0 0 1 1 1 0 BUD22 Mpp10 PF04006.12 CDI85887.1 - 1.8 6.9 37.0 1.9 6.9 37.0 1.0 1 0 0 1 1 1 0 Mpp10 protein DNA_pol_phi PF04931.13 CDI85887.1 - 2.1 6.3 39.8 2.3 6.2 39.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi FYDLN_acid PF09538.10 CDI85887.1 - 4.6 8.0 25.3 7.2 7.3 25.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) RPN2_C PF18004.1 CDI85887.1 - 5.6 6.9 35.0 6.4 6.7 35.0 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CobT PF06213.12 CDI85887.1 - 7.2 5.9 34.5 7.8 5.8 34.5 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT GETHR PF05671.11 CDI85889.1 - 5.5e-07 28.8 9.1 5.5e-07 28.8 9.1 7.7 5 3 0 5 5 5 2 GETHR pentapeptide repeat (5 copies) Spt20 PF12090.8 CDI85890.1 - 0.46 10.1 8.5 0.56 9.8 8.5 1.1 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI85890.1 - 1.1 9.2 8.6 1.3 9.0 8.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.19 CDI85890.1 - 1.3 9.6 12.0 2.1 9.0 12.0 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein SUIM_assoc PF16619.5 CDI85890.1 - 5.2 7.2 15.3 1.9 8.6 5.8 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 CDI85891.1 - 3.3e-05 23.0 7.8 3.3e-05 23.0 7.8 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI85891.1 - 5.9e-05 23.2 19.6 9.5e-05 22.6 19.6 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI85891.1 - 0.0038 17.5 14.7 0.0038 17.5 14.7 3.5 2 1 1 3 3 3 2 Anti-sigma-K factor rskA MecA PF05389.12 CDI85891.1 - 0.015 14.9 0.4 0.026 14.2 0.4 1.4 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF4834 PF16118.5 CDI85891.1 - 0.022 15.7 2.8 0.022 15.7 2.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 CDI85891.1 - 0.026 13.3 3.0 0.016 14.0 1.4 1.5 2 0 0 2 2 2 0 Presenilin Sec62 PF03839.16 CDI85891.1 - 0.042 13.3 2.5 0.069 12.7 2.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 EOS1 PF12326.8 CDI85891.1 - 0.049 13.6 0.9 0.079 12.9 0.9 1.4 1 1 0 1 1 1 0 N-glycosylation protein Peptidase_C58 PF03543.14 CDI85891.1 - 0.061 13.0 10.4 0.11 12.2 10.4 1.4 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen SpoIIP PF07454.11 CDI85891.1 - 0.071 12.6 3.2 0.11 11.9 3.2 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RICTOR_N PF14664.6 CDI85891.1 - 0.11 11.5 1.3 0.19 10.7 1.3 1.3 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term CPSF100_C PF13299.6 CDI85891.1 - 0.12 12.6 3.1 0.15 12.3 1.1 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal EPL1 PF10513.9 CDI85891.1 - 0.15 12.5 5.0 0.15 12.4 2.9 2.0 2 0 0 2 2 2 0 Enhancer of polycomb-like CLN3 PF02487.17 CDI85891.1 - 0.17 10.9 1.4 0.27 10.2 1.4 1.2 1 0 0 1 1 1 0 CLN3 protein EIIBC-GUT_N PF03612.14 CDI85891.1 - 0.4 10.4 5.7 0.81 9.4 5.7 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus PH_4 PF15404.6 CDI85891.1 - 0.54 10.0 5.2 1.1 9.0 5.2 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain V_ATPase_I PF01496.19 CDI85891.1 - 0.56 8.0 4.0 5 4.9 6.2 1.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family eIF-3_zeta PF05091.12 CDI85891.1 - 0.64 8.9 8.8 0.91 8.4 8.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rxt3 PF08642.10 CDI85891.1 - 0.67 10.7 4.1 0.32 11.8 0.6 2.2 3 0 0 3 3 2 0 Histone deacetylation protein Rxt3 BRF1 PF07741.13 CDI85891.1 - 0.92 9.9 10.9 0.088 13.2 5.8 1.9 2 0 0 2 2 1 0 Brf1-like TBP-binding domain DUF2368 PF10166.9 CDI85891.1 - 1.4 8.5 8.3 2.9 7.5 8.3 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) DUF4770 PF15994.5 CDI85891.1 - 1.6 8.9 11.8 3 8.0 11.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) TMEM208_SND2 PF05620.11 CDI85891.1 - 3.5 7.4 8.3 6.9 6.4 8.3 1.5 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 OATP PF03137.20 CDI85891.1 - 7.4 4.7 7.6 0.37 9.0 1.7 1.6 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family RBP_receptor PF14752.6 CDI85891.1 - 8.2 4.9 9.5 12 4.3 9.5 1.2 1 0 0 1 1 1 0 Retinol binding protein receptor DUF5427 PF10310.9 CDI85891.1 - 8.8 5.2 18.6 0.045 12.7 9.3 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5427) DUF3464 PF11947.8 CDI85891.1 - 9.7 5.9 11.1 30 4.3 11.1 1.8 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Peptidase_S49_N PF08496.10 CDI85891.1 - 9.9 6.2 9.4 20 5.2 9.4 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SseC PF04888.12 CDI85892.1 - 0.0003 20.5 5.2 0.00054 19.7 5.2 1.3 1 0 0 1 1 1 1 Secretion system effector C (SseC) like family MecA PF05389.12 CDI85892.1 - 0.0078 15.9 2.3 0.0078 15.9 2.3 2.3 2 1 0 2 2 2 1 Negative regulator of genetic competence (MecA) LMBR1 PF04791.16 CDI85892.1 - 0.061 12.2 7.1 0.083 11.8 7.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Pex14_N PF04695.13 CDI85892.1 - 0.57 10.8 26.7 0.07 13.8 11.0 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF5427 PF10310.9 CDI85892.1 - 0.96 8.3 31.3 0.0056 15.7 9.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5427) SpoIIP PF07454.11 CDI85892.1 - 1.6 8.1 16.4 0.48 9.8 4.4 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) CPSF100_C PF13299.6 CDI85892.1 - 3.6 7.7 20.6 5.1 7.3 7.0 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal NARP1 PF12569.8 CDI85892.1 - 4.7 6.0 20.3 0.046 12.6 2.9 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 GNAT_acetyltr_2 PF13718.6 CDI85893.1 - 0.021 14.3 13.8 0.024 14.0 13.8 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DUF913 PF06025.12 CDI85893.1 - 0.022 13.8 16.1 0.024 13.6 16.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Vfa1 PF08432.10 CDI85893.1 - 0.034 14.5 25.0 0.038 14.3 25.0 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 CDI85893.1 - 0.076 12.8 28.0 0.085 12.7 28.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PTPRCAP PF15713.5 CDI85893.1 - 0.086 13.1 26.5 0.1 12.9 26.5 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Tim54 PF11711.8 CDI85893.1 - 0.096 11.5 21.4 0.11 11.3 21.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Presenilin PF01080.17 CDI85893.1 - 0.098 11.4 27.7 0.1 11.4 27.7 1.0 1 0 0 1 1 1 0 Presenilin Pox_Ag35 PF03286.14 CDI85893.1 - 0.11 12.2 15.7 0.13 12.1 15.7 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RPN2_C PF18004.1 CDI85893.1 - 0.13 12.2 21.6 0.18 11.7 21.6 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF2052 PF09747.9 CDI85893.1 - 0.13 12.4 28.0 0.14 12.3 28.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) MCM_bind PF09739.9 CDI85893.1 - 0.14 10.6 18.7 0.14 10.6 18.7 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor FAM60A PF15396.6 CDI85893.1 - 0.18 11.8 17.7 0.2 11.6 17.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF4050 PF13259.6 CDI85893.1 - 0.18 12.1 19.7 0.21 11.9 19.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) DDHD PF02862.17 CDI85893.1 - 0.24 11.5 19.6 0.31 11.2 19.6 1.2 1 0 0 1 1 1 0 DDHD domain Merozoite_SPAM PF07133.11 CDI85893.1 - 0.26 11.3 25.3 0.31 11.0 25.3 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DUF2828 PF11443.8 CDI85893.1 - 0.31 9.1 21.4 0.31 9.1 21.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Connexin PF00029.19 CDI85893.1 - 0.32 10.7 17.7 0.38 10.5 17.7 1.3 1 0 0 1 1 1 0 Connexin DUF2126 PF09899.9 CDI85893.1 - 0.36 8.8 14.7 0.4 8.7 14.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) TRAP_alpha PF03896.16 CDI85893.1 - 0.38 9.9 13.5 0.43 9.7 13.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Gti1_Pac2 PF09729.9 CDI85893.1 - 0.48 10.5 18.2 0.51 10.4 18.2 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family NARP1 PF12569.8 CDI85893.1 - 0.51 9.2 24.5 0.59 9.0 24.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 NPR3 PF03666.13 CDI85893.1 - 0.59 8.9 24.1 0.62 8.8 24.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNA_pol_Rpc4 PF05132.14 CDI85893.1 - 0.6 10.5 20.6 0.75 10.2 20.6 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 CLN3 PF02487.17 CDI85893.1 - 0.62 9.1 19.1 0.72 8.8 19.1 1.0 1 0 0 1 1 1 0 CLN3 protein Rtf2 PF04641.12 CDI85893.1 - 0.63 9.4 21.3 0.74 9.1 21.3 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger CDC45 PF02724.14 CDI85893.1 - 0.66 8.2 24.7 0.71 8.1 24.7 1.0 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI85893.1 - 0.8 8.7 23.7 0.83 8.6 23.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SpoIIP PF07454.11 CDI85893.1 - 0.8 9.1 26.0 1.1 8.6 26.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TMEM214 PF10151.9 CDI85893.1 - 1.1 7.6 18.2 1.4 7.3 18.2 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator DUF4638 PF15472.6 CDI85893.1 - 1.1 8.9 18.5 1.1 8.9 18.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DDRGK PF09756.9 CDI85893.1 - 1.1 8.8 39.4 1.4 8.5 39.4 1.1 1 0 0 1 1 1 0 DDRGK domain DUF4776 PF16003.5 CDI85893.1 - 1.2 8.0 20.2 1.3 8.0 20.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) CCSAP PF15748.5 CDI85893.1 - 1.2 9.2 29.5 1.5 9.0 29.5 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CCDC53 PF10152.9 CDI85893.1 - 1.3 9.5 24.2 1.7 9.0 24.2 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Hamartin PF04388.12 CDI85893.1 - 1.4 7.5 21.1 1.5 7.4 21.1 1.0 1 0 0 1 1 1 0 Hamartin protein DUF4637 PF15470.6 CDI85893.1 - 1.4 8.6 18.1 2 8.1 18.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Sec62 PF03839.16 CDI85893.1 - 1.5 8.3 20.0 1.5 8.3 20.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Trypan_PARP PF05887.11 CDI85893.1 - 1.6 8.7 4.6 1.9 8.5 4.6 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Smg8_Smg9 PF10220.9 CDI85893.1 - 1.7 6.9 24.4 1.8 6.7 24.4 1.0 1 0 0 1 1 1 0 Smg8_Smg9 PIP5K PF01504.18 CDI85893.1 - 1.7 7.8 18.2 2 7.6 18.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Raftlin PF15250.6 CDI85893.1 - 1.7 7.3 18.9 1.7 7.3 18.9 1.0 1 0 0 1 1 1 0 Raftlin AAA_11 PF13086.6 CDI85893.1 - 1.8 8.3 24.3 1.9 8.2 24.3 1.0 1 0 0 1 1 1 0 AAA domain Lin-8 PF03353.15 CDI85893.1 - 1.8 8.1 28.8 2 7.9 28.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4045 PF13254.6 CDI85893.1 - 2 8.0 21.8 2 8.0 21.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Endostatin PF06482.11 CDI85893.1 - 2 7.8 20.0 2.2 7.7 20.0 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin ALMT PF11744.8 CDI85893.1 - 2.1 7.1 19.3 2.3 7.0 19.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4746 PF15928.5 CDI85893.1 - 2.2 7.6 22.3 2.6 7.4 22.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CSG2 PF16965.5 CDI85893.1 - 2.3 7.1 13.9 2.5 7.0 13.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator SAPS PF04499.15 CDI85893.1 - 2.3 6.9 19.8 2.4 6.8 19.8 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Band_3_cyto PF07565.13 CDI85893.1 - 2.5 7.8 20.6 3.7 7.3 20.6 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Nha1_C PF08619.10 CDI85893.1 - 2.7 7.1 32.0 3.2 6.9 32.0 1.0 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus DUF5427 PF10310.9 CDI85893.1 - 2.7 6.8 28.1 3.1 6.6 28.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) MAJIN PF15077.6 CDI85893.1 - 3 7.6 20.5 3.4 7.4 20.5 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein Pal1 PF08316.11 CDI85893.1 - 3.1 8.5 12.8 5.1 7.8 12.8 1.3 1 0 0 1 1 1 0 Pal1 cell morphology protein DUF2151 PF10221.9 CDI85893.1 - 3.1 6.3 15.4 3.3 6.2 15.4 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Baculo_PP31 PF05311.11 CDI85893.1 - 3.2 7.1 18.8 3.8 6.9 18.8 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Folliculin PF11704.8 CDI85893.1 - 3.3 7.6 18.0 3.6 7.4 18.0 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Hid1 PF12722.7 CDI85893.1 - 3.5 5.6 23.3 3.6 5.6 23.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CENP-N PF05238.13 CDI85893.1 - 3.9 6.7 18.5 4.4 6.5 18.5 1.0 1 0 0 1 1 1 0 Kinetochore protein CHL4 like Asp-B-Hydro_N PF05279.11 CDI85893.1 - 3.9 7.5 25.0 4.5 7.3 25.0 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Membralin PF09746.9 CDI85893.1 - 4 6.4 15.3 4.3 6.3 15.3 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF4569 PF15133.6 CDI85893.1 - 4.2 7.0 24.3 4.8 6.8 24.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) DUF2072 PF09845.9 CDI85893.1 - 4.2 7.6 18.7 6 7.1 18.7 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein CobT PF06213.12 CDI85893.1 - 4.7 6.5 38.6 6.4 6.1 38.6 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT GAGA_bind PF06217.12 CDI85893.1 - 4.7 7.4 19.5 5.3 7.2 19.5 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family ESM4 PF15952.5 CDI85893.1 - 4.8 7.6 33.1 6.2 7.2 33.1 1.1 1 0 0 1 1 1 0 Enhancer of split M4 family MDM10 PF12519.8 CDI85893.1 - 4.8 5.9 21.2 4.9 5.9 21.2 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF740 PF05340.12 CDI85893.1 - 4.8 5.8 15.0 5.1 5.7 15.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF740) Neur_chan_memb PF02932.16 CDI85893.1 - 4.8 7.2 19.7 5.2 7.0 19.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RP-C_C PF11800.8 CDI85893.1 - 4.9 7.2 23.7 5.5 7.0 23.7 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region XRN_M PF17846.1 CDI85893.1 - 5.2 5.9 19.2 5.7 5.8 19.2 1.0 1 0 0 1 1 1 0 Xrn1 helical domain DUF3886 PF13025.6 CDI85893.1 - 5.7 7.2 40.7 11 6.3 9.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3886) BORG_CEP PF14957.6 CDI85893.1 - 6.8 7.9 18.2 8 7.7 18.2 1.1 1 0 0 1 1 1 0 Cdc42 effector Afi1 PF07792.12 CDI85893.1 - 7 7.1 24.4 9.5 6.7 24.4 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Velvet PF11754.8 CDI85893.1 - 7.1 6.5 20.1 8.7 6.2 20.1 1.1 1 0 0 1 1 1 0 Velvet factor V_ATPase_I PF01496.19 CDI85893.1 - 7.1 4.4 27.5 8.6 4.1 27.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family STAC2_u1 PF16664.5 CDI85893.1 - 8.1 6.9 19.6 12 6.4 19.6 1.3 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 DUF2347 PF09804.9 CDI85893.1 - 8.2 5.9 15.4 9.5 5.7 15.4 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) MCD PF05292.11 CDI85893.1 - 8.2 5.9 12.1 9.5 5.7 12.1 1.3 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain PAT1 PF09770.9 CDI85893.1 - 8.2 4.5 37.5 9.3 4.4 37.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Zip PF02535.22 CDI85893.1 - 8.7 5.4 16.4 10 5.2 16.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Otopetrin PF03189.13 CDI85893.1 - 9.4 4.9 14.6 11 4.7 14.6 1.1 1 0 0 1 1 1 0 Otopetrin RNA_pol_Rpb1_1 PF04997.12 CDI85894.1 - 1.8e-41 142.5 0.0 1.8e-41 142.5 0.0 1.9 1 1 1 2 2 1 1 RNA polymerase Rpb1, domain 1 AIF_C PF14721.6 CDI85894.1 - 0.00069 20.0 6.0 0.001 19.5 6.0 1.2 1 0 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term TFIIA PF03153.13 CDI85894.1 - 0.0011 19.0 30.9 0.0014 18.8 30.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 CDI85894.1 - 0.0096 15.0 8.5 0.21 10.5 10.0 1.9 2 0 0 2 2 2 1 Solute carrier family 12 DDHD PF02862.17 CDI85894.1 - 0.013 15.7 7.8 0.015 15.5 7.8 1.1 1 0 0 1 1 1 0 DDHD domain UPF0560 PF10577.9 CDI85894.1 - 0.013 14.0 18.9 0.016 13.7 18.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 eIF-3_zeta PF05091.12 CDI85894.1 - 0.016 14.2 16.0 0.019 14.0 16.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RR_TM4-6 PF06459.12 CDI85894.1 - 0.017 15.0 8.9 0.021 14.7 8.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CCDC53 PF10152.9 CDI85894.1 - 0.019 15.4 10.8 0.024 15.1 10.8 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Presenilin PF01080.17 CDI85894.1 - 0.02 13.7 11.8 0.023 13.5 11.8 1.1 1 0 0 1 1 1 0 Presenilin DUF3391 PF11871.8 CDI85894.1 - 0.026 15.1 13.8 0.05 14.1 12.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) PRR22 PF15776.5 CDI85894.1 - 0.04 13.3 0.8 0.42 9.9 0.8 1.8 1 1 0 1 1 1 0 Proline-rich protein family 22 CPSF100_C PF13299.6 CDI85894.1 - 0.052 13.7 8.2 0.075 13.2 8.2 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Ctr PF04145.15 CDI85894.1 - 0.063 13.9 2.8 0.079 13.6 2.8 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Suf PF05843.14 CDI85894.1 - 0.083 12.9 17.3 0.11 12.5 17.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Pex14_N PF04695.13 CDI85894.1 - 0.089 13.4 22.9 0.16 12.6 22.9 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PIP5K PF01504.18 CDI85894.1 - 0.091 12.0 7.9 0.11 11.7 7.9 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2828 PF11443.8 CDI85894.1 - 0.092 10.8 10.2 0.11 10.6 10.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Velvet PF11754.8 CDI85894.1 - 0.098 12.6 13.4 0.13 12.2 13.4 1.1 1 0 0 1 1 1 0 Velvet factor Gti1_Pac2 PF09729.9 CDI85894.1 - 0.11 12.6 7.8 0.14 12.2 7.8 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4834 PF16118.5 CDI85894.1 - 0.19 12.7 15.9 0.37 11.8 15.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Baculo_PP31 PF05311.11 CDI85894.1 - 0.2 11.1 11.0 0.25 10.8 11.0 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Ndc1_Nup PF09531.10 CDI85894.1 - 0.23 10.1 7.2 0.22 10.2 7.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4820 PF16091.5 CDI85894.1 - 0.39 10.1 10.7 0.54 9.6 10.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF913 PF06025.12 CDI85894.1 - 0.44 9.5 8.3 0.57 9.1 8.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) AAA_23 PF13476.6 CDI85894.1 - 0.53 10.7 16.3 0.71 10.3 16.3 1.2 1 0 0 1 1 1 0 AAA domain EOS1 PF12326.8 CDI85894.1 - 0.55 10.1 5.6 0.66 9.9 5.6 1.2 1 0 0 1 1 1 0 N-glycosylation protein SpoIIP PF07454.11 CDI85894.1 - 0.56 9.6 19.1 0.77 9.2 19.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Spt20 PF12090.8 CDI85894.1 - 0.58 9.7 46.0 1.2 8.7 46.0 1.5 1 0 0 1 1 1 0 Spt20 family CSG2 PF16965.5 CDI85894.1 - 0.6 9.0 6.6 0.7 8.8 6.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Serinc PF03348.15 CDI85894.1 - 0.76 8.6 6.4 0.87 8.4 6.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Neur_chan_memb PF02932.16 CDI85894.1 - 0.76 9.8 9.4 0.85 9.6 9.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LMBR1 PF04791.16 CDI85894.1 - 0.8 8.5 5.5 0.8 8.5 5.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4175 PF13779.6 CDI85894.1 - 0.88 7.4 33.5 1.1 7.1 33.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CobT PF06213.12 CDI85894.1 - 0.91 8.9 22.1 1.3 8.3 22.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SprA-related PF12118.8 CDI85894.1 - 0.93 8.6 26.6 1.1 8.3 26.6 1.1 1 0 0 1 1 1 0 SprA-related family SID-1_RNA_chan PF13965.6 CDI85894.1 - 0.94 7.8 4.6 1.1 7.6 4.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Band_3_cyto PF07565.13 CDI85894.1 - 0.97 9.2 12.7 1.4 8.7 12.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain ALMT PF11744.8 CDI85894.1 - 1 8.1 8.4 1.1 8.0 8.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Peroxin-13_N PF04088.13 CDI85894.1 - 1.1 9.6 5.8 1.4 9.2 5.8 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region EIIBC-GUT_N PF03612.14 CDI85894.1 - 1.6 8.4 12.8 2.3 8.0 12.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CLN3 PF02487.17 CDI85894.1 - 2.1 7.3 10.1 2.5 7.0 10.1 1.1 1 0 0 1 1 1 0 CLN3 protein Paf1 PF03985.13 CDI85894.1 - 2.2 7.2 16.9 3 6.8 16.9 1.1 1 0 0 1 1 1 0 Paf1 NARP1 PF12569.8 CDI85894.1 - 2.5 6.9 15.3 3.4 6.5 15.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4407 PF14362.6 CDI85894.1 - 3.2 7.0 20.4 4 6.7 20.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Folate_carrier PF01770.18 CDI85894.1 - 3.7 6.2 7.4 4.7 5.9 7.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier NPR3 PF03666.13 CDI85894.1 - 5.2 5.7 16.2 8 5.1 16.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 G0-G1_switch_2 PF15103.6 CDI85894.1 - 6.6 7.2 11.1 12 6.4 11.1 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 DUF3408 PF11888.8 CDI85894.1 - 7.2 6.8 17.4 12 6.0 17.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) V_ATPase_I PF01496.19 CDI85894.1 - 9.1 4.0 17.6 12 3.6 17.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pex14_N PF04695.13 CDI85895.1 - 0.071 13.8 20.3 0.094 13.4 20.3 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SLC12 PF03522.15 CDI85895.1 - 0.083 11.9 31.9 0.091 11.8 31.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Rrn6 PF10214.9 CDI85895.1 - 0.099 11.1 23.0 0.14 10.6 23.0 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor TFIIF_alpha PF05793.12 CDI85895.1 - 0.14 10.7 41.4 0.18 10.3 41.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 CDI85895.1 - 0.18 10.1 33.0 0.2 9.9 33.0 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF5427 PF10310.9 CDI85895.1 - 0.27 10.2 40.9 0.3 10.0 40.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Auxin_canalis PF05703.11 CDI85895.1 - 0.32 10.9 26.2 0.4 10.6 26.2 1.2 1 0 0 1 1 1 0 Auxin canalisation NPR3 PF03666.13 CDI85895.1 - 0.36 9.6 34.1 0.42 9.4 34.1 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 LRIF1 PF15741.5 CDI85895.1 - 0.62 8.5 31.5 0.64 8.5 31.5 1.0 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 ALMT PF11744.8 CDI85895.1 - 0.85 8.4 28.8 0.99 8.2 28.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Draxin PF15550.6 CDI85895.1 - 0.86 9.4 28.6 1 9.1 28.6 1.1 1 0 0 1 1 1 0 Draxin Presenilin PF01080.17 CDI85895.1 - 1.2 7.8 35.7 1.4 7.6 35.7 1.1 1 0 0 1 1 1 0 Presenilin Endostatin PF06482.11 CDI85895.1 - 1.7 8.0 25.9 2.1 7.7 25.9 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF4569 PF15133.6 CDI85895.1 - 1.8 8.2 29.9 2.2 7.9 29.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Hid1 PF12722.7 CDI85895.1 - 2.2 6.3 31.3 2.5 6.1 31.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Zip PF02535.22 CDI85895.1 - 3.7 6.7 21.6 5 6.2 21.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Suf PF05843.14 CDI85895.1 - 4.3 7.2 31.4 5.1 7.0 31.4 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SOBP PF15279.6 CDI85895.1 - 4.5 7.8 24.6 5.4 7.5 24.6 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Nop53 PF07767.11 CDI85895.1 - 4.6 6.5 61.3 6.4 6.1 61.3 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF3527 PF12043.8 CDI85895.1 - 4.6 6.7 23.9 5.5 6.5 23.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) Velvet PF11754.8 CDI85895.1 - 5 7.0 17.1 6.9 6.5 17.1 1.3 1 0 0 1 1 1 0 Velvet factor DUF4614 PF15391.6 CDI85895.1 - 5 7.1 25.9 7.2 6.6 25.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) MAJIN PF15077.6 CDI85895.1 - 5.1 6.8 27.7 6 6.6 27.7 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF2151 PF10221.9 CDI85895.1 - 6.1 5.3 29.0 6.9 5.1 29.0 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator DUF4551 PF15087.6 CDI85895.1 - 7.5 5.3 29.4 9 5.0 29.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CAC1F_C PF16885.5 CDI85895.1 - 8.2 6.0 20.3 9.4 5.8 20.3 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Miga PF10265.9 CDI85895.1 - 8.4 5.2 21.7 10 4.9 21.7 1.2 1 0 0 1 1 1 0 Mitoguardin Spt20 PF12090.8 CDI85897.1 - 0.00073 19.2 13.6 0.00073 19.2 13.6 3.2 2 1 1 3 3 3 1 Spt20 family DUF2722 PF10846.8 CDI85897.1 - 0.0015 17.6 10.2 0.0015 17.6 10.2 3.9 2 1 0 2 2 2 1 Protein of unknown function (DUF2722) Plasmodium_Vir PF05795.11 CDI85897.1 - 0.64 9.4 30.3 0.15 11.5 18.7 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Peptidase_S49_N PF08496.10 CDI85897.1 - 2.2 8.3 24.5 5.7 7.0 1.9 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Usp PF00582.26 CDI85898.1 - 0.17 12.4 1.5 0.72 10.4 1.5 2.2 1 0 0 1 1 1 0 Universal stress protein family DUF4922 PF16269.5 CDI85898.1 - 7.4 6.3 7.6 13 5.5 7.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4922) LMBR1 PF04791.16 CDI85899.1 - 2.2 7.1 3.2 0.69 8.7 0.5 1.5 2 0 0 2 2 2 0 LMBR1-like membrane protein V_ATPase_I PF01496.19 CDI85900.1 - 0.42 8.5 10.7 0.6 8.0 10.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4746 PF15928.5 CDI85900.1 - 9.8 5.5 8.6 17 4.7 8.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4637 PF15470.6 CDI85903.1 - 0.3 10.8 3.3 0.59 9.8 3.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Trp_oprn_chp PF09534.10 CDI85904.1 - 0.2 11.4 11.1 0.23 11.3 11.1 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) AMP-binding PF00501.28 CDI85905.1 - 5.3e-13 48.3 0.0 8.7e-06 24.6 0.0 2.5 3 0 0 3 3 3 2 AMP-binding enzyme tRNA-synt_2b PF00587.25 CDI85906.1 - 2.6e-25 89.4 0.0 3.6e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) WD40 PF00400.32 CDI85907.1 - 2.3e-12 47.2 6.3 0.0092 16.8 0.2 6.1 7 1 0 7 7 7 3 WD domain, G-beta repeat AAA_6 PF12774.7 CDI85908.1 - 9.2e-146 485.0 0.0 2.9e-145 483.3 0.0 2.0 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 CDI85908.1 - 4e-119 398.8 7.7 4e-119 398.8 7.7 2.9 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 CDI85908.1 - 3.6e-104 349.0 7.7 3.6e-104 349.0 7.7 4.5 3 2 1 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 CDI85908.1 - 1.7e-68 229.7 0.5 4.8e-62 208.7 0.0 3.7 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_5 PF07728.14 CDI85908.1 - 4.9e-22 78.4 0.4 2.5e-05 24.3 0.0 5.7 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 CDI85908.1 - 1.4e-19 70.4 0.0 6.2e-19 68.4 0.0 2.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 CDI85908.1 - 6.5e-17 61.6 0.1 3e-16 59.4 0.1 2.3 1 0 0 1 1 1 1 AAA+ lid domain AAA_8 PF12780.7 CDI85908.1 - 3.4e-16 59.4 1.7 3.4e-16 59.4 1.7 2.2 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 AAA_16 PF13191.6 CDI85908.1 - 5.2e-08 33.5 3.3 0.39 11.1 0.0 6.0 6 0 0 6 6 5 2 AAA ATPase domain AAA_22 PF13401.6 CDI85908.1 - 1.6e-07 31.7 1.0 0.24 11.6 0.0 4.9 4 0 0 4 4 4 2 AAA domain AAA PF00004.29 CDI85908.1 - 1.3e-05 25.6 0.1 0.18 12.3 0.1 4.2 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CDI85908.1 - 7.9e-05 23.2 1.7 0.32 11.6 0.0 4.6 4 0 0 4 4 3 1 AAA domain FtsK_SpoIIIE PF01580.18 CDI85908.1 - 0.0026 17.2 0.1 1.6 8.1 0.0 3.3 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_30 PF13604.6 CDI85908.1 - 0.004 16.9 3.1 0.6 9.8 0.0 3.4 4 0 0 4 4 4 1 AAA domain Sigma54_activat PF00158.26 CDI85908.1 - 0.0047 16.6 0.1 4 7.1 0.0 3.2 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_28 PF13521.6 CDI85908.1 - 0.013 15.7 0.1 4.5 7.5 0.0 3.1 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CDI85908.1 - 0.021 15.2 0.5 17 5.8 0.0 4.2 4 0 0 4 4 4 0 RNA helicase TniB PF05621.11 CDI85908.1 - 0.035 13.5 0.0 0.16 11.4 0.0 2.2 1 0 0 1 1 1 0 Bacterial TniB protein DUF853 PF05872.12 CDI85908.1 - 0.069 11.7 2.5 0.91 8.0 0.1 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) AAA_29 PF13555.6 CDI85908.1 - 0.083 12.6 1.0 13 5.6 0.0 3.7 3 0 0 3 3 3 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDI85908.1 - 0.092 12.6 0.1 1.4 8.8 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase AAA_19 PF13245.6 CDI85908.1 - 0.18 12.1 4.5 49 4.2 0.1 4.6 4 0 0 4 4 4 0 AAA domain AAA_33 PF13671.6 CDI85908.1 - 0.25 11.5 0.8 50 4.0 0.0 3.8 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 CDI85908.1 - 3 7.4 6.2 10 5.6 0.2 4.1 4 0 0 4 4 4 0 AAA domain AAA_9 PF12781.7 CDI85909.1 - 9.3e-80 266.9 3.8 9.3e-80 266.9 3.8 2.8 3 0 0 3 3 3 1 ATP-binding dynein motor region Dynein_C PF18199.1 CDI85909.1 - 1.6e-69 234.5 1.8 8.2e-69 232.2 0.0 2.8 2 1 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 CDI85909.1 - 1e-59 202.0 0.0 1.9e-59 201.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_lid_11 PF18198.1 CDI85909.1 - 1.2e-54 184.6 0.0 2.5e-54 183.5 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 CDI85909.1 - 4.8e-52 177.1 9.3 1.1e-51 175.9 9.3 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 CDI85909.1 - 4.9e-38 129.9 0.0 4.6e-37 126.7 0.0 2.6 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain MPS2 PF17060.5 CDI85909.1 - 0.5 9.6 11.1 0.15 11.3 3.6 2.2 2 0 0 2 2 2 0 Monopolar spindle protein 2 Spc7 PF08317.11 CDI85909.1 - 0.51 9.2 32.5 0.0078 15.1 5.6 3.3 3 0 0 3 3 3 0 Spc7 kinetochore protein DUF16 PF01519.16 CDI85909.1 - 6.6 7.3 17.8 0.46 11.0 1.8 3.9 3 1 0 3 3 3 0 Protein of unknown function DUF16 Ran_BP1 PF00638.18 CDI85912.1 - 3.3e-05 24.1 1.1 3.3e-05 24.1 1.1 2.0 2 1 0 2 2 2 1 RanBP1 domain Pes-10 PF07149.11 CDI85912.1 - 0.27 10.3 12.5 0.3 10.1 12.5 1.0 1 0 0 1 1 1 0 Pes-10 CobT PF06213.12 CDI85912.1 - 2.2 7.6 15.2 2.3 7.6 15.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4834 PF16118.5 CDI85912.1 - 3.2 8.8 13.1 4.1 8.4 13.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Eapp_C PF10238.9 CDI85912.1 - 3.6 7.7 9.1 4.9 7.2 9.1 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein CPSF100_C PF13299.6 CDI85912.1 - 5.2 7.2 11.9 5.6 7.1 11.9 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Vfa1 PF08432.10 CDI85912.1 - 5.8 7.2 21.5 6.8 7.0 21.5 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RNA_pol_Rpc4 PF05132.14 CDI85912.1 - 6 7.3 12.8 6.7 7.1 12.8 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 RNA_polI_A34 PF08208.11 CDI85912.1 - 6.5 6.8 21.7 7 6.7 21.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RP-C_C PF11800.8 CDI85912.1 - 7 6.7 11.9 7.6 6.6 11.9 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region Lin-8 PF03353.15 CDI85914.1 - 0.048 13.2 0.3 0.048 13.2 0.3 2.4 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Apt1 PF10351.9 CDI85914.1 - 4.8 5.9 23.5 0.1 11.4 1.5 2.4 2 0 0 2 2 2 0 Golgi-body localisation protein domain RskA PF10099.9 CDI85915.1 - 4.8e-05 23.7 1.5 4.8e-05 23.7 1.5 7.3 2 2 4 6 6 6 2 Anti-sigma-K factor rskA DUF1645 PF07816.11 CDI85915.1 - 0.00033 21.3 11.9 0.00033 21.3 11.9 6.9 4 3 1 5 5 5 1 Protein of unknown function (DUF1645) Ocular_alb PF02101.15 CDI85916.1 - 0.026 13.4 0.7 0.06 12.3 0.7 1.5 1 0 0 1 1 1 0 Ocular albinism type 1 protein Ribosomal_60s PF00428.19 CDI85917.1 - 0.016 15.8 5.5 0.016 15.8 5.5 3.5 2 1 1 3 3 3 0 60s Acidic ribosomal protein PA26 PF04636.13 CDI85917.1 - 0.86 8.5 11.3 0.051 12.5 6.4 1.4 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) ASD2 PF08687.11 CDI85917.1 - 1.1 8.8 15.3 0.6 9.6 10.9 2.0 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Dsh_C PF12316.8 CDI85917.1 - 1.9 8.9 34.7 1.5 9.2 6.8 2.1 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Hamartin PF04388.12 CDI85917.1 - 2.3 6.8 21.3 2.9 6.4 21.3 1.1 1 0 0 1 1 1 0 Hamartin protein DivIC PF04977.15 CDI85917.1 - 3.6 7.4 11.7 7.7 6.4 11.7 1.5 1 0 0 1 1 1 0 Septum formation initiator SR-25 PF10500.9 CDI85917.1 - 4 7.0 53.2 14 5.2 8.0 3.2 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein CCDC106 PF15794.5 CDI85917.1 - 6.5 6.4 26.2 4 7.1 15.2 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 EF-hand_1 PF00036.32 CDI85918.1 - 0.0003 20.1 0.0 0.00045 19.6 0.0 1.3 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 CDI85918.1 - 0.00042 19.7 0.0 0.00072 18.9 0.0 1.3 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CDI85918.1 - 0.00063 19.5 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain Utp14 PF04615.13 CDI85918.1 - 0.16 10.6 18.3 0.2 10.2 18.3 1.2 1 0 0 1 1 1 0 Utp14 protein EF-hand_8 PF13833.6 CDI85918.1 - 0.18 11.7 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair LMBR1 PF04791.16 CDI85918.1 - 0.24 10.2 4.2 0.33 9.8 4.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein CLN3 PF02487.17 CDI85918.1 - 0.39 9.7 5.7 0.88 8.5 5.7 1.7 1 0 0 1 1 1 0 CLN3 protein Sporozoite_P67 PF05642.11 CDI85918.1 - 1.5 6.8 15.8 2.3 6.2 15.8 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FliP PF00813.20 CDI85918.1 - 3.8 7.3 5.0 8.9 6.1 5.0 1.7 1 0 0 1 1 1 0 FliP family BNIP2 PF12496.8 CDI85918.1 - 3.9 7.9 9.3 6.2 7.3 5.7 2.7 3 1 0 3 3 3 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Macoilin PF09726.9 CDI85919.1 - 0.0052 15.4 32.9 0.0083 14.7 32.9 1.3 1 0 0 1 1 1 1 Macoilin family GAGA_bind PF06217.12 CDI85919.1 - 2.9 8.1 20.8 4.6 7.4 17.0 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family LptF_LptG PF03739.14 CDI85919.1 - 3.1 6.6 6.9 6.1 5.6 6.9 1.6 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG DUF4746 PF15928.5 CDI85919.1 - 6.2 6.1 22.9 4.6 6.6 20.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Peroxin-13_N PF04088.13 CDI85920.1 - 0.01 16.1 7.2 0.01 16.1 7.2 2.0 1 1 1 2 2 2 0 Peroxin 13, N-terminal region DUF2052 PF09747.9 CDI85920.1 - 0.12 12.5 20.3 0.16 12.1 20.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Presenilin PF01080.17 CDI85920.1 - 0.14 10.9 25.1 0.17 10.6 25.1 1.1 1 0 0 1 1 1 0 Presenilin SARAF PF06682.12 CDI85920.1 - 0.21 11.2 17.5 0.26 10.9 17.5 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis GRP PF07172.11 CDI85920.1 - 0.22 12.2 12.5 1.8 9.3 2.6 2.1 1 1 1 2 2 2 0 Glycine rich protein family Conotoxin PF02950.17 CDI85920.1 - 0.37 11.8 22.6 1.8 9.7 5.2 2.4 1 1 1 2 2 2 0 Conotoxin Orf78 PF06024.12 CDI85920.1 - 0.39 11.1 22.9 0.16 12.2 7.9 2.1 1 1 1 2 2 2 0 Orf78 (ac78) RR_TM4-6 PF06459.12 CDI85920.1 - 0.4 10.5 22.1 0.54 10.0 22.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4366 PF14283.6 CDI85920.1 - 0.42 10.7 11.8 22 5.1 11.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) DUF2828 PF11443.8 CDI85920.1 - 0.44 8.6 23.2 0.55 8.3 23.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Tmemb_9 PF05434.11 CDI85920.1 - 0.57 10.1 24.5 0.57 10.1 9.2 2.0 1 1 1 2 2 2 0 TMEM9 DUF3357 PF11837.8 CDI85920.1 - 0.66 10.5 8.2 5.8 7.4 0.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) DUF572 PF04502.13 CDI85920.1 - 0.97 9.0 19.1 1.5 8.4 19.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Ac76 PF05814.11 CDI85920.1 - 1.3 9.1 8.1 2.1 8.4 1.4 2.2 1 1 1 2 2 2 0 Orf76 (Ac76) Rtf2 PF04641.12 CDI85920.1 - 1.5 8.1 20.1 2.1 7.6 20.1 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger PBP1_TM PF14812.6 CDI85920.1 - 1.5 9.2 12.0 5e+02 1.1 12.0 2.2 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC45 PF02724.14 CDI85920.1 - 1.6 7.0 18.9 2 6.6 18.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Otopetrin PF03189.13 CDI85920.1 - 1.7 7.4 15.7 2.5 6.8 15.7 1.2 1 0 0 1 1 1 0 Otopetrin TMEM51 PF15345.6 CDI85920.1 - 1.8 8.3 38.9 1.4 8.7 17.4 2.0 1 1 1 2 2 2 0 Transmembrane protein 51 FAM209 PF15206.6 CDI85920.1 - 2 8.2 14.4 5.7 6.7 13.2 1.8 1 1 1 2 2 2 0 FAM209 family TRAP_alpha PF03896.16 CDI85920.1 - 2.3 7.4 12.7 3.4 6.8 3.7 2.0 1 1 1 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit ALMT PF11744.8 CDI85920.1 - 2.3 6.9 23.2 2.9 6.6 23.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Scs3p PF10261.9 CDI85920.1 - 2.9 7.4 18.7 0.59 9.6 4.4 2.0 1 1 1 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM SLC12 PF03522.15 CDI85920.1 - 3.3 6.6 27.5 3.8 6.4 27.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 EphA2_TM PF14575.6 CDI85920.1 - 3.4 8.6 25.7 3.3 8.6 7.3 2.5 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Trp_oprn_chp PF09534.10 CDI85920.1 - 3.8 7.3 7.2 9.8 5.9 7.2 1.7 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) FGF-BP1 PF06473.12 CDI85920.1 - 4.3 7.1 31.9 1.8 8.3 10.0 2.1 1 1 1 2 2 2 0 FGF binding protein 1 (FGF-BP1) Endostatin PF06482.11 CDI85920.1 - 4.3 6.7 23.8 5.4 6.4 23.8 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin MAPEG PF01124.18 CDI85920.1 - 6.3 6.7 10.2 9.2 6.2 1.7 2.0 1 1 1 2 2 2 0 MAPEG family DUF819 PF05684.12 CDI85920.1 - 7.8 5.4 8.3 8.3 5.3 1.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF819) AAA_11 PF13086.6 CDI85920.1 - 8.6 6.1 25.4 10 5.8 25.4 1.0 1 0 0 1 1 1 0 AAA domain Neur_chan_memb PF02932.16 CDI85920.1 - 8.7 6.3 21.2 12 5.8 21.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM176 PF14851.6 CDI85920.1 - 9.3 5.9 20.4 6.3 6.5 7.6 2.0 1 1 1 2 2 2 0 FAM176 family XRN_M PF17846.1 CDI85920.1 - 9.6 5.0 20.5 10 4.9 20.5 1.0 1 0 0 1 1 1 0 Xrn1 helical domain PrmA PF06325.13 CDI85921.1 - 2.4e-08 33.7 0.3 2.4e-08 33.7 0.3 3.3 3 1 0 3 3 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 CDI85921.1 - 8.4e-08 32.8 0.4 8.4e-08 32.8 0.4 4.0 4 2 1 5 5 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI85921.1 - 5.1e-06 26.4 1.4 5.1e-06 26.4 1.4 3.7 2 2 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI85921.1 - 8.3e-06 25.7 0.8 8.3e-06 25.7 0.8 3.4 2 2 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 CDI85921.1 - 5.2e-05 22.9 0.0 5.2e-05 22.9 0.0 2.9 2 1 0 2 2 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 CDI85921.1 - 7.8e-05 23.2 0.0 7.8e-05 23.2 0.0 4.2 3 2 2 5 5 3 1 Methyltransferase domain Spt20 PF12090.8 CDI85921.1 - 0.00014 21.6 6.8 0.00014 21.6 6.8 4.5 3 1 1 4 4 2 1 Spt20 family DUF2722 PF10846.8 CDI85921.1 - 0.00021 20.4 3.0 0.00021 20.4 3.0 4.4 3 1 1 4 4 2 1 Protein of unknown function (DUF2722) Methyltransf_18 PF12847.7 CDI85921.1 - 0.0055 16.6 0.0 0.016 15.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI85921.1 - 0.078 13.7 0.1 0.078 13.7 0.1 4.8 3 2 1 4 4 4 0 Methyltransferase domain Ubie_methyltran PF01209.18 CDI85921.1 - 0.14 11.5 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 CDI85921.1 - 0.31 9.9 0.0 0.31 9.9 0.0 2.8 3 1 0 3 3 2 0 Protein of unknown function (DUF1698) AAA_23 PF13476.6 CDI85921.1 - 0.95 9.9 25.4 0.076 13.5 11.0 2.4 2 0 0 2 2 2 0 AAA domain Spore_YhcN_YlaJ PF09580.10 CDI85921.1 - 1.2 9.2 21.6 1.1 9.3 0.1 3.4 2 1 1 3 3 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Mgr1 PF08602.10 CDI85921.1 - 6.2 5.5 9.8 0.41 9.4 3.1 2.3 2 0 0 2 2 2 0 Mgr1-like, i-AAA protease complex subunit zf-HIT PF04438.16 CDI85922.1 - 0.0021 17.9 18.0 0.0021 17.9 18.0 1.5 2 0 0 2 2 2 1 HIT zinc finger TFIIA PF03153.13 CDI85923.1 - 1.8e-06 28.2 75.2 0.00044 20.4 16.8 2.3 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Endostatin PF06482.11 CDI85923.1 - 0.0039 16.7 25.4 0.15 11.5 15.1 2.3 2 0 0 2 2 2 2 Collagenase NC10 and Endostatin Presenilin PF01080.17 CDI85923.1 - 0.0058 15.5 34.3 0.11 11.2 19.4 2.7 3 0 0 3 3 3 2 Presenilin ORC5_C PF14630.6 CDI85923.1 - 0.006 16.1 4.3 0.006 16.1 4.3 2.9 2 1 0 2 2 1 1 Origin recognition complex (ORC) subunit 5 C-terminus DUF2052 PF09747.9 CDI85923.1 - 0.17 12.0 30.1 0.24 11.5 16.4 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF1387 PF07139.11 CDI85923.1 - 0.21 11.3 33.8 0.45 10.2 9.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) RR_TM4-6 PF06459.12 CDI85923.1 - 0.33 10.8 32.9 0.44 10.3 17.7 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 GAGA_bind PF06217.12 CDI85923.1 - 0.56 10.4 25.7 0.72 10.1 2.4 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family CLN3 PF02487.17 CDI85923.1 - 0.59 9.1 22.1 0.68 8.9 11.6 2.3 2 0 0 2 2 2 0 CLN3 protein SLC12 PF03522.15 CDI85923.1 - 0.71 8.8 32.3 1.4 7.8 5.6 2.2 2 0 0 2 2 2 0 Solute carrier family 12 DUF913 PF06025.12 CDI85923.1 - 0.78 8.7 24.3 1.3 8.0 1.0 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) ASD2 PF08687.11 CDI85923.1 - 1.1 8.8 37.8 3.2 7.2 7.5 2.4 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Isy1 PF06246.12 CDI85923.1 - 1.5 8.3 29.2 0.75 9.3 4.2 2.3 2 0 0 2 2 2 0 Isy1-like splicing family Ribosomal_60s PF00428.19 CDI85923.1 - 1.9 9.1 9.8 2.1 9.0 7.3 2.4 2 0 0 2 2 1 0 60s Acidic ribosomal protein RIFIN PF02009.16 CDI85923.1 - 2.1 8.2 26.2 1.1 9.0 15.2 2.3 2 0 0 2 2 2 0 Rifin DUF3446 PF11928.8 CDI85923.1 - 2.1 8.7 23.7 7.5 6.9 11.4 4.2 3 0 0 3 3 3 0 Early growth response N-terminal domain PRP1_N PF06424.12 CDI85923.1 - 2.3 8.6 23.7 1.7 9.1 10.6 2.7 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal PA26 PF04636.13 CDI85923.1 - 2.4 7.0 28.1 0.2 10.5 5.1 2.2 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) V_ATPase_I PF01496.19 CDI85923.1 - 2.9 5.7 32.7 1.4 6.8 5.6 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Spore_YhcN_YlaJ PF09580.10 CDI85923.1 - 3.3 7.8 25.6 3.7 7.6 2.3 2.5 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) VIR_N PF15912.5 CDI85923.1 - 3.7 7.1 19.0 0.41 10.2 7.9 2.3 2 0 0 2 2 2 0 Virilizer, N-terminal FAM60A PF15396.6 CDI85923.1 - 4 7.4 29.6 0.88 9.5 2.6 3.0 3 0 0 3 3 3 0 Protein Family FAM60A Spore_coat_CotO PF14153.6 CDI85923.1 - 4.4 7.2 43.2 5.5 6.9 7.9 2.5 2 0 0 2 2 2 0 Spore coat protein CotO Prenyltransf PF01255.19 CDI85923.1 - 5.1 6.6 13.9 0.22 11.0 2.3 2.4 2 0 0 2 2 2 0 Putative undecaprenyl diphosphate synthase ALMT PF11744.8 CDI85923.1 - 6.1 5.5 28.0 2.9 6.6 16.8 2.2 2 0 0 2 2 2 0 Aluminium activated malate transporter Band_3_cyto PF07565.13 CDI85923.1 - 7.2 6.3 31.3 0.15 11.8 2.0 2.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain O-antigen_lig PF13425.6 CDI85923.1 - 8.2 5.1 14.9 0.32 9.8 6.5 2.0 2 0 0 2 2 2 0 O-antigen ligase like membrane protein TT_ORF1 PF02956.14 CDI85923.1 - 9.5 4.8 23.7 1.6 7.3 0.4 2.1 2 0 0 2 2 2 0 TT viral orf 1 SID-1_RNA_chan PF13965.6 CDI85923.1 - 9.5 4.5 17.6 1.7 6.9 7.2 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 RskA PF10099.9 CDI85925.1 - 0.0037 17.6 1.7 0.0037 17.6 1.7 5.9 1 1 4 6 6 6 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI85926.1 - 0.00028 20.6 43.4 0.0048 16.5 3.8 4.2 4 0 0 4 4 4 2 Spt20 family DUF2722 PF10846.8 CDI85926.1 - 0.0077 15.2 2.3 0.0077 15.2 2.3 4.1 4 0 0 4 4 4 2 Protein of unknown function (DUF2722) Spore_YhcN_YlaJ PF09580.10 CDI85926.1 - 0.051 13.7 2.3 0.16 12.1 2.3 1.8 1 1 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) RskA PF10099.9 CDI85926.1 - 0.062 13.6 55.1 0.095 13.0 10.0 4.9 3 2 0 4 4 4 0 Anti-sigma-K factor rskA LETM1 PF07766.13 CDI85926.1 - 0.13 11.5 3.8 0.16 11.3 0.1 2.3 2 0 0 2 2 2 0 LETM1-like protein Dala_Dala_lig_C PF07478.13 CDI85926.1 - 0.17 11.4 0.3 0.4 10.2 0.3 1.5 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus GDE_N PF12439.8 CDI85926.1 - 0.46 9.9 3.4 0.93 8.9 0.1 2.3 2 0 0 2 2 2 0 Glycogen debranching enzyme N terminal DASH_Dad2 PF08654.10 CDI85926.1 - 0.48 10.9 8.7 15 6.1 0.1 2.9 2 0 0 2 2 2 0 DASH complex subunit Dad2 Striatin PF08232.12 CDI85926.1 - 0.59 10.7 15.8 0.064 13.9 6.1 3.2 4 0 0 4 4 4 0 Striatin family ANAPC_CDC26 PF10471.9 CDI85926.1 - 1.3 9.9 48.1 0.75 10.7 6.4 5.2 5 0 0 5 5 5 0 Anaphase-promoting complex APC subunit CDC26 AGO_N PF18236.1 CDI85926.1 - 1.4 9.1 4.5 0.87 9.8 0.2 2.3 2 0 0 2 2 2 0 Argonaute N domain Dehydrin PF00257.19 CDI85927.1 - 1.3 9.5 13.3 2 8.9 12.7 1.6 1 1 1 2 2 2 0 Dehydrin Spore_coat_CotO PF14153.6 CDI85927.1 - 5 7.0 12.0 5.9 6.8 12.0 1.0 1 0 0 1 1 1 0 Spore coat protein CotO Sporozoite_P67 PF05642.11 CDI85928.1 - 0.00054 18.2 11.6 0.0007 17.8 11.6 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen TFIIA PF03153.13 CDI85928.1 - 0.0045 17.0 18.9 0.0065 16.5 18.9 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Secretin_N_2 PF07655.13 CDI85928.1 - 0.0051 17.3 3.9 0.0051 17.3 3.9 2.2 2 0 0 2 2 2 1 Secretin N-terminal domain Kinesin_assoc PF16183.5 CDI85928.1 - 2 8.5 5.7 4 7.6 1.8 2.1 2 0 0 2 2 2 0 Kinesin-associated SR-25 PF10500.9 CDI85928.1 - 4.1 6.9 29.1 0.41 10.2 17.7 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CDK2AP PF09806.9 CDI85928.1 - 5.5 7.0 31.2 3.9 7.5 8.4 2.1 1 1 1 2 2 2 0 Cyclin-dependent kinase 2-associated protein TPR_11 PF13414.6 CDI85929.1 - 1.6e-09 37.3 0.2 6.1e-06 25.8 0.0 3.7 3 1 1 4 4 4 3 TPR repeat TPR_2 PF07719.17 CDI85929.1 - 6.8e-09 35.2 10.6 0.014 15.4 1.7 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDI85929.1 - 2.5e-08 34.1 40.9 0.00011 22.7 0.1 6.3 4 1 2 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDI85929.1 - 5.8e-07 29.2 0.2 0.011 15.9 0.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDI85929.1 - 5.7e-05 22.8 2.4 0.27 11.1 0.3 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDI85929.1 - 0.00014 22.0 4.9 0.00014 22.0 4.9 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDI85929.1 - 0.00049 20.7 16.6 0.00049 20.7 16.6 5.8 3 2 3 6 6 3 3 Tetratricopeptide repeat SR-25 PF10500.9 CDI85929.1 - 0.063 12.9 20.8 0.49 10.0 5.5 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein TPR_17 PF13431.6 CDI85929.1 - 0.079 13.4 7.6 0.36 11.3 0.1 3.7 4 0 0 4 4 2 0 Tetratricopeptide repeat OrfB_Zn_ribbon PF07282.11 CDI85929.1 - 0.12 12.3 0.2 0.26 11.3 0.2 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain TPR_6 PF13174.6 CDI85929.1 - 1 10.1 0.0 1 10.1 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat GREB1 PF15782.5 CDI85929.1 - 2.9 4.9 11.1 4.3 4.3 11.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIA PF03153.13 CDI85929.1 - 7 6.5 38.8 15 5.4 38.8 1.6 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_16 PF13191.6 CDI85932.1 - 7.6e-08 32.9 0.0 8.2e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 CDI85932.1 - 0.0016 18.4 0.0 0.0017 18.3 0.0 1.1 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_5 PF07728.14 CDI85932.1 - 0.0038 17.2 0.0 0.0083 16.1 0.0 1.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CDI85932.1 - 0.011 16.2 0.0 0.02 15.3 0.0 1.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 CDI85932.1 - 0.014 15.4 0.0 0.017 15.1 0.0 1.1 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 CDI85932.1 - 0.043 14.2 0.0 0.06 13.7 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 CDI85932.1 - 0.048 13.9 0.0 0.063 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDI85932.1 - 0.05 14.2 0.0 0.081 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDI85932.1 - 0.072 12.6 0.0 0.09 12.3 0.0 1.1 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 CDI85932.1 - 0.089 12.7 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain TIP49 PF06068.13 CDI85932.1 - 0.1 11.7 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 TIP49 P-loop domain RsgA_GTPase PF03193.16 CDI85932.1 - 0.13 12.2 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 RsgA GTPase AAA_19 PF13245.6 CDI85932.1 - 0.14 12.4 0.0 0.18 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Fes1 PF08609.10 CDI85933.1 - 0.03 15.2 0.6 0.077 13.9 0.6 1.8 1 1 0 1 1 1 0 Nucleotide exchange factor Fes1 Utp14 PF04615.13 CDI85934.1 - 1.3 7.5 53.3 1.5 7.3 53.3 1.0 1 0 0 1 1 1 0 Utp14 protein Tim54 PF11711.8 CDI85934.1 - 2.2 7.0 49.2 3 6.5 23.1 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF2749 PF10907.8 CDI85934.1 - 6.4 7.0 7.6 11 6.2 6.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2749) SURF2 PF05477.11 CDI85936.1 - 0.018 14.7 12.1 0.018 14.7 0.9 2.2 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) DUF2828 PF11443.8 CDI85936.1 - 0.6 8.1 10.7 0.4 8.7 4.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Tim54 PF11711.8 CDI85936.1 - 0.67 8.7 18.0 1.1 8.0 8.7 2.3 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 ATP11 PF06644.11 CDI85936.1 - 0.7 9.6 26.4 0.031 14.1 2.0 2.8 3 0 0 3 3 3 0 ATP11 protein FAM60A PF15396.6 CDI85936.1 - 0.79 9.7 11.8 4.3 7.3 0.1 2.5 2 0 0 2 2 2 0 Protein Family FAM60A Zip PF02535.22 CDI85936.1 - 0.9 8.7 9.7 7.8 5.6 5.3 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter Band_3_cyto PF07565.13 CDI85936.1 - 0.92 9.3 13.7 3.4 7.4 1.6 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF5523 PF17661.1 CDI85936.1 - 1 9.0 18.6 0.8 9.3 7.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5523) SpoIIP PF07454.11 CDI85936.1 - 1.5 8.2 22.3 3.4 7.1 11.2 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 CDI85936.1 - 2.7 7.7 13.1 4.8 6.9 4.8 2.2 2 0 0 2 2 2 0 Connexin PPL5 PF18168.1 CDI85936.1 - 4.2 6.6 12.3 12 5.1 6.5 2.4 2 0 0 2 2 2 0 Prim-pol family 5 MecA PF05389.12 CDI85936.1 - 6.9 6.2 12.2 2.2 7.8 3.4 2.4 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) ASD2 PF08687.11 CDI85936.1 - 8 5.9 23.5 0.7 9.4 10.0 2.3 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 MMR1 PF08505.10 CDI85936.1 - 8.4 6.6 25.8 0.41 10.9 3.1 2.5 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein TFIIA PF03153.13 CDI85937.1 - 0.00024 21.2 46.2 0.033 14.2 25.3 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 CDI85937.1 - 0.005 17.8 0.2 0.005 17.8 0.2 3.4 2 1 0 2 2 1 1 Domain of unknown function (DUF4834) Activator_LAG-3 PF11498.8 CDI85937.1 - 0.008 15.2 15.9 0.008 15.2 15.9 2.6 2 1 0 2 2 1 1 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI85937.1 - 0.013 15.1 18.1 0.013 15.1 18.1 3.1 2 1 1 3 3 2 0 Spt20 family DUF4820 PF16091.5 CDI85937.1 - 0.065 12.6 0.2 0.065 12.6 0.2 3.1 2 1 1 3 3 2 0 Domain of unknown function (DUF4820) SH3_12 PF18129.1 CDI85937.1 - 0.2 11.8 0.0 1.2 9.3 0.0 2.0 1 1 0 1 1 1 0 Xrn1 SH3-like domain Sin_N PF04801.13 CDI85937.1 - 0.35 10.0 36.2 0.29 10.3 18.3 2.2 2 0 0 2 2 2 0 Sin-like protein conserved region RCR PF12273.8 CDI85937.1 - 0.53 10.9 14.2 2.5 8.8 0.1 2.4 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red MAT1 PF06391.13 CDI85937.1 - 0.67 9.7 22.4 2 8.2 4.2 2.4 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Lin-8 PF03353.15 CDI85937.1 - 1 8.9 26.9 1.6 8.2 14.8 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Spc7_N PF15402.6 CDI85937.1 - 1.2 7.3 25.0 0.4 8.9 15.6 2.0 2 0 0 2 2 2 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF4471 PF14740.6 CDI85937.1 - 1.3 8.1 8.6 2.5 7.2 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) PIP5K PF01504.18 CDI85937.1 - 2.4 7.3 13.7 0.62 9.2 0.1 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase SpoIIP PF07454.11 CDI85937.1 - 2.9 7.3 21.3 1.5 8.2 4.0 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF2126 PF09899.9 CDI85937.1 - 4.6 5.2 10.7 1.1 7.2 0.1 2.1 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) FAM176 PF14851.6 CDI85937.1 - 5.5 6.6 14.8 2 8.0 1.7 2.4 2 0 0 2 2 2 0 FAM176 family CAF1 PF04857.20 CDI85937.1 - 5.7 6.0 11.9 31 3.6 11.9 1.8 1 1 0 1 1 1 0 CAF1 family ribonuclease Afi1 PF07792.12 CDI85937.1 - 6.1 7.3 18.6 1.6 9.2 1.7 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RR_TM4-6 PF06459.12 CDI85937.1 - 7.1 6.4 21.2 0.83 9.4 2.3 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI85937.1 - 7.5 5.5 17.7 4 6.4 1.4 2.2 2 0 0 2 2 2 0 Solute carrier family 12 PNISR PF15996.5 CDI85937.1 - 8.9 6.5 30.8 3 8.1 14.6 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR DUF2052 PF09747.9 CDI85937.1 - 9 6.4 22.1 5.6 7.0 3.4 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Sec62 PF03839.16 CDI85937.1 - 9.3 5.7 13.3 3 7.3 3.4 2.3 2 0 0 2 2 2 0 Translocation protein Sec62 Aconitase_C PF00694.19 CDI85938.1 - 0.0078 16.5 30.4 0.035 14.4 7.4 2.3 1 1 1 2 2 2 2 Aconitase C-terminal domain PAP2 PF01569.21 CDI85938.1 - 0.65 9.8 4.2 0.83 9.4 0.0 2.6 2 1 0 2 2 2 0 PAP2 superfamily RCC1 PF00415.18 CDI85939.1 - 4.4e-17 62.5 10.0 7.4e-07 29.7 0.9 4.0 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDI85939.1 - 0.00045 19.9 13.4 0.0069 16.2 2.7 3.7 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat PPP4R2 PF09184.11 CDI85939.1 - 4.1 6.9 27.6 5 6.6 3.2 2.5 2 1 0 2 2 2 0 PPP4R2 RskA PF10099.9 CDI85939.1 - 4.2 7.6 49.0 10 6.4 11.4 5.0 3 1 1 4 4 4 0 Anti-sigma-K factor rskA Zip PF02535.22 CDI85939.1 - 7.3 5.7 14.1 9 5.4 0.6 2.5 2 0 0 2 2 2 0 ZIP Zinc transporter Spt20 PF12090.8 CDI85940.1 - 0.0027 17.3 18.7 0.0027 17.3 18.7 4.8 4 1 0 4 4 4 2 Spt20 family SARAF PF06682.12 CDI85940.1 - 0.0028 17.4 0.5 0.0028 17.4 0.5 4.8 1 1 0 3 3 3 1 SOCE-associated regulatory factor of calcium homoeostasis CDC45 PF02724.14 CDI85940.1 - 0.27 9.5 50.0 0.076 11.3 23.8 3.2 3 0 0 3 3 3 0 CDC45-like protein DUF4746 PF15928.5 CDI85940.1 - 1.3 8.3 41.7 0.3 10.5 4.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4746) Spt20 PF12090.8 CDI85941.1 - 0.0021 17.7 48.0 0.042 13.5 16.5 2.1 2 0 0 2 2 2 2 Spt20 family MctB PF11382.8 CDI85941.1 - 0.036 13.8 1.4 0.036 13.8 1.4 2.1 2 0 0 2 2 2 0 Copper transport outer membrane protein, MctB U1snRNP70_N PF12220.8 CDI85941.1 - 0.059 14.0 13.9 0.17 12.6 7.1 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal SR-25 PF10500.9 CDI85941.1 - 0.19 11.3 72.9 0.69 9.5 34.7 3.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Roughex PF06020.11 CDI85941.1 - 0.58 9.2 25.4 1.2 8.2 14.2 2.2 2 0 0 2 2 2 0 Drosophila roughex protein DUF4407 PF14362.6 CDI85941.1 - 1.5 8.1 21.2 1.8 7.9 21.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF775 PF05603.12 CDI85941.1 - 1.6 8.2 23.9 0.016 14.8 4.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF775) CDK5_activator PF03261.15 CDI85941.1 - 2 7.9 23.1 2.8 7.4 23.1 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Coilin_N PF15862.5 CDI85941.1 - 2.3 8.0 28.6 0.51 10.1 10.3 2.4 2 0 0 2 2 2 0 Coilin N-terminus baeRF_family10 PF18854.1 CDI85941.1 - 2.5 8.4 14.3 2.6 8.3 2.2 2.1 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 Apc15p PF05841.11 CDI85941.1 - 2.9 8.7 32.2 0.21 12.4 6.7 2.3 2 0 0 2 2 2 0 Apc15p protein Spem1 PF15670.5 CDI85941.1 - 4.8 6.7 27.6 4.4 6.8 13.0 2.2 2 0 0 2 2 2 0 Spermatid maturation protein 1 NPR1_interact PF15699.5 CDI85941.1 - 6.4 7.5 17.8 6.5 7.4 7.1 2.5 2 0 0 2 2 2 0 NPR1 interacting Tox-WTIP PF15654.6 CDI85941.1 - 9.9 6.6 7.5 2.8 8.4 0.5 2.3 2 0 0 2 2 2 0 Toxin with a conserved tryptophan and TIP tripeptide motif SID-1_RNA_chan PF13965.6 CDI85942.1 - 0.69 8.3 3.2 0.93 7.8 3.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI85942.1 - 0.8 8.6 5.7 1.4 7.8 5.7 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF913 PF06025.12 CDI85942.1 - 1.1 8.2 7.6 2.7 6.9 7.6 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4820 PF16091.5 CDI85942.1 - 1.8 7.9 12.3 1.1 8.6 8.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) RPN2_C PF18004.1 CDI85942.1 - 2.7 7.9 17.7 0.093 12.7 10.8 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain eIF-3_zeta PF05091.12 CDI85942.1 - 3.2 6.6 20.5 0.082 11.9 13.0 1.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ureide_permease PF07168.11 CDI85942.1 - 3.3 6.4 7.3 8.2 5.1 7.3 1.6 1 0 0 1 1 1 0 Ureide permease Folate_carrier PF01770.18 CDI85942.1 - 3.4 6.3 7.7 6 5.5 7.7 1.4 1 0 0 1 1 1 0 Reduced folate carrier SLC12 PF03522.15 CDI85942.1 - 4.9 6.1 14.7 0.89 8.5 10.1 1.8 2 0 0 2 2 2 0 Solute carrier family 12 MDM31_MDM32 PF08118.11 CDI85942.1 - 6.6 5.3 10.7 16 4.1 10.7 1.6 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins FAM60A PF15396.6 CDI85942.1 - 7.1 6.6 11.9 1 9.4 7.2 1.9 2 0 0 2 2 2 0 Protein Family FAM60A Band_3_cyto PF07565.13 CDI85942.1 - 8.2 6.1 15.8 2.5 7.8 10.5 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Rxt3 PF08642.10 CDI85942.1 - 8.7 7.1 9.7 1.8 9.4 3.4 2.5 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 SpoIIP PF07454.11 CDI85942.1 - 9.7 5.6 19.1 0.48 9.8 11.9 2.0 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) CSG2 PF16965.5 CDI85942.1 - 9.9 5.0 7.2 17 4.2 7.2 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator PTPRCAP PF15713.5 CDI85943.1 - 0.2 11.9 25.0 0.21 11.8 25.0 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DDRGK PF09756.9 CDI85943.1 - 1.1 8.8 36.8 1.3 8.6 36.8 1.0 1 0 0 1 1 1 0 DDRGK domain FAM76 PF16046.5 CDI85943.1 - 1.7 8.0 19.9 1.8 7.8 19.9 1.0 1 0 0 1 1 1 0 FAM76 protein DUF4637 PF15470.6 CDI85943.1 - 2.3 7.9 18.1 2.9 7.6 18.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) SpoIIP PF07454.11 CDI85943.1 - 2.7 7.4 18.1 3 7.2 18.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF3408 PF11888.8 CDI85943.1 - 3.8 7.6 20.1 5.5 7.1 20.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Zip PF02535.22 CDI85943.1 - 4.1 6.5 13.5 4.1 6.5 13.5 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 CDI85943.1 - 5.5 5.2 24.2 5.7 5.1 24.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI85943.1 - 5.6 5.6 24.1 5.8 5.6 24.1 1.0 1 0 0 1 1 1 0 Presenilin Asp-B-Hydro_N PF05279.11 CDI85943.1 - 6.2 6.8 22.1 7.1 6.6 22.1 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region BORG_CEP PF14957.6 CDI85943.1 - 6.3 8.0 12.4 7.6 7.7 12.4 1.2 1 0 0 1 1 1 0 Cdc42 effector BAF1_ABF1 PF04684.13 CDI85943.1 - 6.9 5.6 20.3 7.7 5.4 20.3 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FAM176 PF14851.6 CDI85943.1 - 7 6.3 17.5 9.7 5.9 17.5 1.3 1 0 0 1 1 1 0 FAM176 family CPSF100_C PF13299.6 CDI85943.1 - 7.8 6.7 18.6 9.3 6.4 18.6 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SelP_N PF04592.14 CDI85943.1 - 8.7 5.7 20.8 9.8 5.5 20.8 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Merozoite_SPAM PF07133.11 CDI85943.1 - 8.8 6.3 22.8 9.7 6.1 22.8 1.0 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) MAP17 PF15807.5 CDI85943.1 - 8.9 6.6 14.5 11 6.3 14.5 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Tim54 PF11711.8 CDI85943.1 - 9.1 4.9 19.3 10 4.8 19.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TRAP_alpha PF03896.16 CDI85943.1 - 9.1 5.4 12.0 9.8 5.3 12.0 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Gti1_Pac2 PF09729.9 CDI85943.1 - 9.2 6.3 17.5 10 6.1 17.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Folate_carrier PF01770.18 CDI85943.1 - 9.5 4.8 10.4 10 4.7 10.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier CCDC24 PF15669.5 CDI85944.1 - 0.00026 21.0 3.2 0.0003 20.7 3.2 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 24 family Spt20 PF12090.8 CDI85944.1 - 0.0021 17.7 4.6 0.0024 17.5 4.6 1.1 1 0 0 1 1 1 1 Spt20 family Sporozoite_P67 PF05642.11 CDI85944.1 - 0.0031 15.7 3.9 0.0034 15.6 3.9 1.0 1 0 0 1 1 1 1 Sporozoite P67 surface antigen DUF1712 PF08217.11 CDI85944.1 - 0.019 13.5 4.3 0.021 13.3 4.3 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1712) Presenilin PF01080.17 CDI85944.1 - 0.023 13.5 1.9 0.025 13.4 1.9 1.1 1 0 0 1 1 1 0 Presenilin AF-4 PF05110.13 CDI85944.1 - 0.046 11.8 22.7 0.056 11.5 22.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SPATIAL PF15256.6 CDI85944.1 - 0.16 12.3 5.0 0.35 11.2 5.0 1.6 1 1 0 1 1 1 0 SPATIAL Cwf_Cwc_15 PF04889.12 CDI85944.1 - 0.19 11.4 9.4 0.25 11.0 9.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein MMU163 PF17119.5 CDI85944.1 - 0.25 10.5 5.7 0.34 10.0 5.7 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Lin-8 PF03353.15 CDI85944.1 - 0.36 10.4 8.7 0.46 10.0 8.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PNISR PF15996.5 CDI85944.1 - 0.44 10.8 8.3 0.58 10.4 8.3 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Apt1 PF10351.9 CDI85944.1 - 0.52 9.1 13.7 0.7 8.7 13.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peroxin-3 PF04882.12 CDI85944.1 - 0.89 8.5 11.0 1.1 8.2 11.0 1.0 1 0 0 1 1 1 0 Peroxin-3 DUF3774 PF12609.8 CDI85944.1 - 1.2 10.2 8.1 13 6.9 4.8 2.3 2 0 0 2 2 2 0 Wound-induced protein BUD22 PF09073.10 CDI85944.1 - 1.3 8.2 14.3 1.8 7.8 14.3 1.1 1 0 0 1 1 1 0 BUD22 Macoilin PF09726.9 CDI85944.1 - 3.5 6.1 13.9 4.8 5.6 13.9 1.2 1 0 0 1 1 1 0 Macoilin family Herpes_pp85 PF04637.12 CDI85944.1 - 3.8 5.8 8.0 4.9 5.4 8.0 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Secretin_N_2 PF07655.13 CDI85944.1 - 9.7 6.8 21.0 9.4 6.9 17.8 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain Spt20 PF12090.8 CDI85945.1 - 0.00095 18.8 24.1 0.0012 18.5 24.1 1.3 1 0 0 1 1 1 1 Spt20 family BBS2_C PF14782.6 CDI85945.1 - 0.079 11.7 8.9 0.095 11.4 8.9 1.0 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal DUF936 PF06075.12 CDI85945.1 - 0.38 9.6 27.2 0.46 9.3 27.2 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Med24_N PF11277.8 CDI85945.1 - 0.42 8.6 15.8 0.5 8.4 15.8 1.0 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal DUF4647 PF15504.6 CDI85945.1 - 0.44 9.6 18.1 0.47 9.5 18.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Draxin PF15550.6 CDI85945.1 - 1 9.1 18.3 1.1 9.1 17.5 1.3 1 1 0 1 1 1 0 Draxin Macoilin PF09726.9 CDI85945.1 - 1.5 7.3 34.6 1.9 7.0 34.6 1.1 1 0 0 1 1 1 0 Macoilin family Plasmodium_Vir PF05795.11 CDI85945.1 - 3.3 7.1 21.4 1.9 7.8 19.4 1.5 1 1 1 2 2 2 0 Plasmodium vivax Vir protein NST1 PF13945.6 CDI85945.1 - 4 7.5 32.5 8.2 6.5 32.5 1.6 1 1 0 1 1 1 0 Salt tolerance down-regulator Roughex PF06020.11 CDI85945.1 - 7.9 5.5 11.9 12 4.8 11.9 1.4 1 0 0 1 1 1 0 Drosophila roughex protein zf-Mss51 PF13824.6 CDI85948.1 - 0.025 14.7 0.6 2 8.5 1.4 2.6 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 Spt20 PF12090.8 CDI85950.1 - 0.0021 17.7 15.5 0.0021 17.7 15.5 2.2 2 0 0 2 2 2 1 Spt20 family SLC12 PF03522.15 CDI85950.1 - 0.021 13.9 7.7 0.025 13.6 7.7 1.2 1 0 0 1 1 1 0 Solute carrier family 12 CSG2 PF16965.5 CDI85950.1 - 0.028 13.4 8.8 0.034 13.1 8.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator PAP2 PF01569.21 CDI85950.1 - 0.033 14.0 0.2 0.085 12.6 0.0 1.7 2 0 0 2 2 2 0 PAP2 superfamily Gti1_Pac2 PF09729.9 CDI85950.1 - 0.043 13.9 5.9 0.043 13.9 2.2 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family Tmp39 PF10271.9 CDI85950.1 - 0.044 12.8 1.7 0.056 12.4 1.7 1.1 1 0 0 1 1 1 0 Putative transmembrane protein Pex14_N PF04695.13 CDI85950.1 - 0.081 13.6 21.4 1.4 9.6 16.2 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SID-1_RNA_chan PF13965.6 CDI85950.1 - 0.33 9.3 3.8 0.44 8.9 3.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RR_TM4-6 PF06459.12 CDI85950.1 - 0.78 9.5 15.3 2.4 7.9 11.1 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RNA_pol_Rbc25 PF08292.12 CDI85950.1 - 0.85 9.9 11.5 0.19 12.0 3.0 2.2 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 SpoIIP PF07454.11 CDI85950.1 - 1.6 8.1 16.5 0.15 11.5 6.3 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Peptidase_S49_N PF08496.10 CDI85950.1 - 1.8 8.6 9.9 0.63 10.1 1.8 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Afi1 PF07792.12 CDI85950.1 - 2.3 8.7 15.4 0.91 10.0 7.4 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking ALMT PF11744.8 CDI85950.1 - 2.4 6.9 9.8 0.9 8.3 6.2 1.8 2 0 0 2 2 2 0 Aluminium activated malate transporter Mem_trans PF03547.18 CDI85950.1 - 2.8 6.3 4.8 1.2 7.5 2.2 1.6 1 1 0 1 1 1 0 Membrane transport protein EPL1 PF10513.9 CDI85950.1 - 2.8 8.3 20.3 1 9.8 10.2 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF3405 PF11885.8 CDI85950.1 - 2.9 6.4 13.3 1.6 7.2 9.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3405) Suf PF05843.14 CDI85950.1 - 4.8 7.1 21.7 6.6 6.6 13.0 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Spc24 PF08286.11 CDI85950.1 - 6.3 7.1 21.7 0.85 9.9 2.8 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Sec62 PF03839.16 CDI85950.1 - 6.5 6.2 10.6 6.3 6.2 5.9 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 Glyco_hydro_9 PF00759.19 CDI85950.1 - 7.5 5.9 14.6 13 5.1 14.6 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 YABBY PF04690.13 CDI85950.1 - 9.1 6.8 13.5 1.8 9.1 6.5 2.1 2 0 0 2 2 2 0 YABBY protein DUF755 PF05501.11 CDI85952.1 - 0.00067 19.9 10.5 0.00067 19.9 10.5 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF755) RskA PF10099.9 CDI85952.1 - 0.0016 18.8 15.3 0.0016 18.8 15.3 3.4 1 1 2 3 3 2 2 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI85952.1 - 0.0063 16.1 9.4 0.0063 16.1 9.4 2.1 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Thymidylate_kin PF02223.17 CDI85952.1 - 0.007 16.1 1.2 0.007 16.1 1.2 2.4 2 1 0 2 2 1 1 Thymidylate kinase Spt20 PF12090.8 CDI85952.1 - 0.0075 15.9 45.7 0.12 11.9 18.6 2.3 2 0 0 2 2 2 2 Spt20 family DUF3807 PF12720.7 CDI85952.1 - 0.027 14.8 17.7 0.21 11.9 8.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) RNA_pol_Rpb8 PF03870.15 CDI85952.1 - 0.041 14.1 2.4 4.8 7.4 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb8 Tau95_N PF17682.1 CDI85952.1 - 0.042 14.0 7.0 0.86 9.8 0.3 2.4 2 0 0 2 2 2 0 Tau95 Triple barrel domain DUF4834 PF16118.5 CDI85952.1 - 0.064 14.2 18.0 1 10.4 6.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) IF3_N PF05198.16 CDI85952.1 - 0.078 13.3 0.1 0.078 13.3 0.1 2.3 2 0 0 2 2 1 0 Translation initiation factor IF-3, N-terminal domain Peptidase_S49_N PF08496.10 CDI85952.1 - 0.1 12.7 16.9 0.12 12.5 7.2 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF2722 PF10846.8 CDI85952.1 - 0.11 11.4 39.7 0.036 13.0 9.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF5421 PF17458.2 CDI85952.1 - 0.11 11.8 21.4 0.16 11.3 7.4 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5421) DUF4647 PF15504.6 CDI85952.1 - 0.19 10.8 18.5 0.049 12.7 5.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) Trnau1ap PF17654.1 CDI85952.1 - 0.26 12.2 19.0 0.4 11.6 3.0 2.3 2 0 0 2 2 2 0 Selenocysteine tRNA 1 associated proteins Connexin PF00029.19 CDI85952.1 - 0.3 10.8 10.5 2.2 8.0 2.5 2.1 2 0 0 2 2 2 0 Connexin Nab6_mRNP_bdg PF10567.9 CDI85952.1 - 0.32 10.5 6.7 7.3 6.0 3.5 2.1 2 0 0 2 2 2 0 RNA-recognition motif DUF2407 PF10302.9 CDI85952.1 - 0.46 11.1 8.3 1.6 9.3 2.1 2.5 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain MPM1 PF17234.2 CDI85952.1 - 0.52 10.6 19.8 0.58 10.4 6.4 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Paf1 PF03985.13 CDI85952.1 - 0.56 9.1 13.8 0.042 12.9 3.8 2.1 2 0 0 2 2 2 0 Paf1 Pal1 PF08316.11 CDI85952.1 - 0.61 10.8 8.5 2.9 8.7 3.0 2.3 2 0 0 2 2 2 0 Pal1 cell morphology protein DUF3474 PF11960.8 CDI85952.1 - 0.64 10.2 6.9 10 6.3 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3474) CTU2 PF10288.9 CDI85952.1 - 0.7 10.1 11.6 2.7 8.3 0.9 2.6 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 CNDH2_M PF16869.5 CDI85952.1 - 0.77 10.5 13.3 2.9 8.6 5.3 2.4 2 0 0 2 2 2 0 PF16858 Isy1 PF06246.12 CDI85952.1 - 0.82 9.2 15.9 1.8 8.1 3.9 2.2 2 0 0 2 2 2 0 Isy1-like splicing family EIIBC-GUT_N PF03612.14 CDI85952.1 - 0.91 9.2 13.9 1.5 8.5 5.9 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus UPF0524 PF15823.5 CDI85952.1 - 0.96 8.8 13.4 0.3 10.4 3.1 2.2 2 0 0 2 2 2 0 UPF0524 of C3orf70 YABBY PF04690.13 CDI85952.1 - 0.97 10.0 14.1 2.4 8.7 5.2 2.3 2 0 0 2 2 2 0 YABBY protein Ferlin_C PF16165.5 CDI85952.1 - 1 9.3 3.9 0.94 9.4 0.4 2.0 2 0 0 2 2 2 0 Ferlin C-terminus DUF3853 PF12964.7 CDI85952.1 - 1.1 9.5 5.6 2.7 8.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3853) NST1 PF13945.6 CDI85952.1 - 1.2 9.2 25.2 3.1 7.9 4.3 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator Roughex PF06020.11 CDI85952.1 - 1.3 8.0 22.9 0.77 8.8 7.2 2.1 2 0 0 2 2 2 0 Drosophila roughex protein TFB6 PF17110.5 CDI85952.1 - 1.6 8.4 6.2 4.9 6.9 2.0 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH O-antigen_lig PF13425.6 CDI85952.1 - 1.7 7.4 7.6 1.4 7.6 1.0 2.0 2 0 0 2 2 2 0 O-antigen ligase like membrane protein Guanylin PF02058.15 CDI85952.1 - 1.7 9.1 12.4 0.23 12.0 5.6 2.3 2 0 0 2 2 2 0 Guanylin precursor ARF7EP_C PF14949.6 CDI85952.1 - 1.7 9.3 11.7 6.1 7.5 0.7 2.4 2 0 0 2 2 2 0 ARF7 effector protein C-terminus NEMP PF10225.9 CDI85952.1 - 1.9 8.1 11.8 1.9 8.1 3.0 2.2 2 0 0 2 2 2 0 NEMP family TERB2 PF15101.6 CDI85952.1 - 2.2 8.3 24.1 0.6 10.1 8.7 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF4770 PF15994.5 CDI85952.1 - 3.1 8.0 21.0 3 8.1 4.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) DUF4692 PF15763.5 CDI85952.1 - 3.2 8.2 13.3 2.2 8.7 6.1 2.3 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) Band_3_cyto PF07565.13 CDI85952.1 - 3.2 7.5 17.8 2.7 7.7 6.3 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain tRNA_lig_CPD PF08302.11 CDI85952.1 - 3.3 7.1 15.6 2 7.8 3.1 2.2 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain XRN1_D2_D3 PF18334.1 CDI85952.1 - 3.6 7.9 8.1 13 6.0 2.0 2.5 2 0 0 2 2 2 0 Exoribonuclease Xrn1 D2/D3 domain UPF0560 PF10577.9 CDI85952.1 - 4.1 5.8 24.2 1.7 7.1 10.2 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 EphA2_TM PF14575.6 CDI85952.1 - 4.3 8.3 12.1 15 6.6 1.3 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SKI PF01202.22 CDI85952.1 - 5 7.2 11.8 0.53 10.4 2.3 2.2 2 0 0 2 2 2 0 Shikimate kinase Spt5_N PF11942.8 CDI85952.1 - 5.5 8.0 11.7 3 8.9 3.1 2.6 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal RuvC_III PF18541.1 CDI85952.1 - 5.8 6.8 14.2 4.6 7.1 3.0 2.3 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 MAGE PF01454.19 CDI85952.1 - 5.9 6.5 18.0 4.4 6.9 3.0 2.2 2 0 0 2 2 2 0 MAGE family RNA_pol_Rbc25 PF08292.12 CDI85952.1 - 6 7.1 9.3 11 6.2 2.3 2.4 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 Pet20 PF08692.10 CDI85952.1 - 6.1 7.6 8.2 13 6.5 2.4 2.2 2 0 0 2 2 2 0 Mitochondrial protein Pet20 CNDH2_N PF06278.11 CDI85952.1 - 7 6.9 13.9 8.7 6.6 3.9 2.4 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal RR_TM4-6 PF06459.12 CDI85952.1 - 7.2 6.3 15.2 4.3 7.1 5.6 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF5352 PF17303.2 CDI85952.1 - 7.5 6.4 9.8 5.2 6.9 1.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5352) Membralin PF09746.9 CDI85952.1 - 8 5.4 10.9 5.6 5.9 3.3 2.0 2 0 0 2 2 2 0 Tumour-associated protein TAS2R PF05296.13 CDI85952.1 - 8.3 5.4 5.9 0.39 9.8 0.4 1.5 2 0 0 2 2 1 0 Taste receptor protein (TAS2R) CLN3 PF02487.17 CDI85952.1 - 9.8 5.1 14.5 5.8 5.8 4.3 2.1 2 0 0 2 2 2 0 CLN3 protein DRIM PF07539.12 CDI85953.1 - 0.004 15.5 5.3 0.0042 15.5 5.3 1.0 1 0 0 1 1 1 1 Down-regulated in metastasis DUF4457 PF14652.6 CDI85953.1 - 0.023 13.9 5.0 0.027 13.7 5.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) MecA PF05389.12 CDI85953.1 - 0.069 12.8 7.4 0.065 12.8 7.4 1.0 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Sarcoglycan_2 PF05510.13 CDI85953.1 - 0.097 11.4 5.1 0.098 11.4 5.1 1.0 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon FAM176 PF14851.6 CDI85953.1 - 0.12 12.1 6.4 0.11 12.2 6.4 1.0 1 0 0 1 1 1 0 FAM176 family PEX11 PF05648.14 CDI85953.1 - 0.13 11.7 7.4 0.15 11.5 7.4 1.0 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) DUF2722 PF10846.8 CDI85953.1 - 0.14 11.1 29.0 0.16 10.9 29.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI85953.1 - 0.14 12.1 27.3 0.13 12.2 27.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI85953.1 - 0.19 11.8 9.8 0.19 11.9 9.8 1.0 1 0 0 1 1 1 0 DDHD domain OmpH PF03938.14 CDI85953.1 - 0.27 11.6 25.7 0.35 11.2 25.7 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3043 PF11241.8 CDI85953.1 - 0.35 10.9 4.2 0.37 10.8 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) EPL1 PF10513.9 CDI85953.1 - 0.39 11.1 11.5 0.38 11.1 11.5 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like Connexin PF00029.19 CDI85953.1 - 0.41 10.4 5.7 0.38 10.5 5.7 1.0 1 0 0 1 1 1 0 Connexin Pex14_N PF04695.13 CDI85953.1 - 0.44 11.2 15.3 0.45 11.2 15.3 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF702 PF05142.12 CDI85953.1 - 0.45 11.0 9.5 0.49 10.9 9.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) TERB2 PF15101.6 CDI85953.1 - 0.53 10.3 15.2 0.56 10.2 15.2 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 EIIBC-GUT_N PF03612.14 CDI85953.1 - 0.58 9.9 8.3 0.58 9.9 8.3 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus SpoIIP PF07454.11 CDI85953.1 - 0.71 9.3 11.2 0.7 9.3 11.2 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Med15 PF09606.10 CDI85953.1 - 0.81 8.3 26.6 0.82 8.3 26.6 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4834 PF16118.5 CDI85953.1 - 0.83 10.7 14.1 0.91 10.5 14.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) FAM60A PF15396.6 CDI85953.1 - 0.95 9.4 5.9 0.92 9.5 5.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF4175 PF13779.6 CDI85953.1 - 1 7.2 30.8 1.1 7.0 30.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Folate_carrier PF01770.18 CDI85953.1 - 1.1 7.9 6.2 1.2 7.8 6.2 1.0 1 0 0 1 1 1 0 Reduced folate carrier MMR1 PF08505.10 CDI85953.1 - 1.3 9.3 13.3 1.2 9.3 13.3 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Presenilin PF01080.17 CDI85953.1 - 1.4 7.6 12.2 1.4 7.6 12.2 1.0 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 CDI85953.1 - 1.4 8.5 35.0 1.6 8.3 35.0 1.1 1 0 0 1 1 1 0 Spt20 family Cellulose_synt PF03552.14 CDI85953.1 - 1.6 7.1 4.1 1.6 7.1 4.1 1.0 1 0 0 1 1 1 0 Cellulose synthase UPF0560 PF10577.9 CDI85953.1 - 1.6 7.1 16.6 1.6 7.2 16.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Neur_chan_memb PF02932.16 CDI85953.1 - 1.7 8.6 7.6 1.8 8.6 7.6 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ureide_permease PF07168.11 CDI85953.1 - 1.8 7.2 4.7 1.8 7.2 4.7 1.0 1 0 0 1 1 1 0 Ureide permease DUF2368 PF10166.9 CDI85953.1 - 2 8.0 14.0 2 8.1 14.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) TrbI PF03743.14 CDI85953.1 - 2.3 8.0 10.1 2.5 7.9 10.1 1.0 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein CLN3 PF02487.17 CDI85953.1 - 2.4 7.1 8.7 2.4 7.1 8.7 1.0 1 0 0 1 1 1 0 CLN3 protein ALMT PF11744.8 CDI85953.1 - 2.5 6.9 7.5 2.3 6.9 7.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter MDM10 PF12519.8 CDI85953.1 - 2.5 6.8 7.9 2.6 6.8 7.9 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 PepSY_TM PF03929.16 CDI85953.1 - 2.6 7.6 4.7 2.5 7.7 4.7 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Bul1_N PF04425.12 CDI85953.1 - 2.7 6.6 10.8 2.9 6.5 10.8 1.0 1 0 0 1 1 1 0 Bul1 N terminus FapA PF03961.13 CDI85953.1 - 2.7 6.5 9.3 2.7 6.5 9.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A AIF_C PF14721.6 CDI85953.1 - 2.8 8.3 7.5 3.2 8.1 7.5 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RR_TM4-6 PF06459.12 CDI85953.1 - 3.3 7.5 10.9 3.8 7.3 10.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 USP8_interact PF08941.10 CDI85953.1 - 3.4 7.4 14.3 3.8 7.3 14.3 1.1 1 0 0 1 1 1 0 USP8 interacting eIF-3_zeta PF05091.12 CDI85953.1 - 3.5 6.5 15.9 3.7 6.4 15.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4199 PF13858.6 CDI85953.1 - 3.5 8.0 6.5 3.9 7.9 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Ndc1_Nup PF09531.10 CDI85953.1 - 3.6 6.2 9.7 3.5 6.2 9.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup OATP PF03137.20 CDI85953.1 - 3.8 5.7 6.4 3.5 5.8 6.4 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Kei1 PF08552.11 CDI85953.1 - 3.8 7.4 5.5 3.9 7.3 5.5 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4407 PF14362.6 CDI85953.1 - 4.1 6.7 17.9 4.4 6.6 17.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FliP PF00813.20 CDI85953.1 - 4.9 7.0 5.7 4.7 7.0 5.7 1.0 1 0 0 1 1 1 0 FliP family V_ATPase_I PF01496.19 CDI85953.1 - 5.1 4.9 11.9 5.1 4.9 11.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Band_3_cyto PF07565.13 CDI85953.1 - 5.1 6.8 11.9 5.3 6.8 11.9 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain O-antigen_lig PF13425.6 CDI85953.1 - 5.2 5.7 5.0 5 5.8 5.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein WASH-7_C PF14746.6 CDI85953.1 - 5.5 6.6 12.4 5.8 6.6 12.4 1.1 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal DUF3381 PF11861.8 CDI85953.1 - 5.7 6.7 19.3 6.5 6.5 19.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) G0-G1_switch_2 PF15103.6 CDI85953.1 - 6.1 7.3 10.9 6.9 7.1 10.9 1.1 1 0 0 1 1 1 0 G0/G1 switch protein 2 Sec62 PF03839.16 CDI85953.1 - 6.7 6.2 9.3 7.9 5.9 9.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 FlaG PF03646.15 CDI85953.1 - 6.9 6.9 22.4 8.5 6.6 22.4 1.1 1 0 0 1 1 1 0 FlaG protein Endonuc_Holl PF10107.9 CDI85953.1 - 7.3 6.4 10.6 8.1 6.3 10.6 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Folliculin PF11704.8 CDI85953.1 - 8.1 6.3 11.6 8.7 6.2 11.6 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF775 PF05603.12 CDI85953.1 - 8.1 5.9 15.1 9.6 5.7 15.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) ATP-synt_E PF05680.12 CDI85953.1 - 8.5 6.8 12.8 12 6.3 12.8 1.2 1 0 0 1 1 1 0 ATP synthase E chain GTA_holin_3TM PF11351.8 CDI85953.1 - 8.8 6.9 12.5 12 6.5 12.5 1.3 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release TMEM51 PF15345.6 CDI85953.1 - 9.6 6.0 15.8 10 5.9 15.8 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 CDC45 PF02724.14 CDI85954.1 - 3.4 5.9 37.0 4.1 5.6 37.0 1.0 1 0 0 1 1 1 0 CDC45-like protein SID-1_RNA_chan PF13965.6 CDI85955.1 - 0.0022 16.5 6.4 0.003 16.1 6.4 1.2 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 TFIIA PF03153.13 CDI85955.1 - 0.013 15.6 58.2 0.016 15.2 58.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 CDI85955.1 - 0.018 14.1 18.7 0.022 13.8 18.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 CDI85955.1 - 0.02 14.8 24.0 0.029 14.2 24.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI85955.1 - 0.072 11.4 37.5 0.085 11.1 37.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 WTX PF09422.10 CDI85955.1 - 0.11 11.6 18.1 0.14 11.2 18.1 1.2 1 0 0 1 1 1 0 WTX protein FAM199X PF15814.5 CDI85955.1 - 0.17 10.9 15.0 0.21 10.6 15.0 1.3 1 0 0 1 1 1 0 Protein family FAM199X SOBP PF15279.6 CDI85955.1 - 0.18 12.4 19.0 0.25 11.9 19.0 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein PPP4R2 PF09184.11 CDI85955.1 - 0.18 11.4 10.9 0.2 11.2 10.9 1.2 1 0 0 1 1 1 0 PPP4R2 O-antigen_lig PF13425.6 CDI85955.1 - 0.26 10.1 8.2 0.29 9.9 8.2 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Hamartin PF04388.12 CDI85955.1 - 0.36 9.4 20.0 0.39 9.3 20.0 1.1 1 0 0 1 1 1 0 Hamartin protein LAP1C PF05609.12 CDI85955.1 - 0.41 9.7 26.5 0.45 9.5 26.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC27 PF09507.10 CDI85955.1 - 0.49 9.7 31.9 0.56 9.5 31.9 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF572 PF04502.13 CDI85955.1 - 0.59 9.7 24.2 0.67 9.5 24.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) EIF4E-T PF10477.9 CDI85955.1 - 0.62 8.8 24.0 0.94 8.2 24.0 1.4 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E PA26 PF04636.13 CDI85955.1 - 0.64 8.9 16.6 0.86 8.5 16.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) eIF-3_zeta PF05091.12 CDI85955.1 - 0.85 8.5 31.1 1.1 8.1 31.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF5523 PF17661.1 CDI85955.1 - 0.93 9.1 24.6 1.2 8.7 24.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) SWI-SNF_Ssr4 PF08549.10 CDI85955.1 - 0.95 8.0 29.8 1.2 7.7 29.8 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Hid1 PF12722.7 CDI85955.1 - 0.98 7.5 24.7 1.1 7.3 24.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AAA_23 PF13476.6 CDI85955.1 - 1.1 9.8 20.3 1.6 9.2 20.3 1.4 1 0 0 1 1 1 0 AAA domain DUF4045 PF13254.6 CDI85955.1 - 1.2 8.7 28.4 1.4 8.4 28.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF4551 PF15087.6 CDI85955.1 - 1.3 7.8 19.7 1.5 7.6 19.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) LMBR1 PF04791.16 CDI85955.1 - 1.3 7.8 13.5 1.5 7.7 13.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Draxin PF15550.6 CDI85955.1 - 1.6 8.5 23.5 2.1 8.2 23.5 1.1 1 0 0 1 1 1 0 Draxin VIR_N PF15912.5 CDI85955.1 - 1.7 8.2 11.9 2.2 7.8 11.9 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal DUF2339 PF10101.9 CDI85955.1 - 1.9 7.0 11.1 2.3 6.7 11.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) PBP1_TM PF14812.6 CDI85955.1 - 2.7 8.4 11.6 0.19 12.1 5.2 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cellulose_synt PF03552.14 CDI85955.1 - 2.8 6.3 7.7 3.2 6.1 7.7 1.3 1 0 0 1 1 1 0 Cellulose synthase GAGA_bind PF06217.12 CDI85955.1 - 3.6 7.8 22.7 4.5 7.5 22.7 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Raftlin PF15250.6 CDI85955.1 - 4 6.1 20.8 6.1 5.5 20.8 1.3 1 0 0 1 1 1 0 Raftlin SAPS PF04499.15 CDI85955.1 - 4.2 6.1 22.9 5.3 5.7 22.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein EMC3_TMCO1 PF01956.16 CDI85955.1 - 4.3 7.0 18.3 1.7 8.3 16.1 1.5 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Caldesmon PF02029.15 CDI85955.1 - 5.4 5.7 30.2 6.7 5.4 30.2 1.1 1 0 0 1 1 1 0 Caldesmon CcmF_C PF16327.5 CDI85955.1 - 5.7 6.1 11.2 7 5.8 11.2 1.0 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal DUF1387 PF07139.11 CDI85955.1 - 6.9 6.3 26.9 9 5.9 26.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Vfa1 PF08432.10 CDI85955.1 - 9.3 6.5 31.0 8.4 6.7 29.2 1.7 1 1 1 2 2 2 0 AAA-ATPase Vps4-associated protein 1 RskA PF10099.9 CDI85956.1 - 0.0095 16.2 7.9 0.0095 16.2 7.9 14.6 5 4 6 12 12 12 4 Anti-sigma-K factor rskA MPM1 PF17234.2 CDI85958.1 - 0.0053 17.0 6.3 0.0053 17.0 6.3 2.1 2 0 0 2 2 2 1 Mitochondrial peculiar membrane protein 1 V_ATPase_I PF01496.19 CDI85958.1 - 0.03 12.2 9.9 0.029 12.3 9.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-3_zeta PF05091.12 CDI85958.1 - 0.061 12.3 12.0 0.063 12.2 12.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) LMBR1 PF04791.16 CDI85958.1 - 0.13 11.1 5.2 0.13 11.1 5.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 CDI85958.1 - 0.61 9.6 25.9 0.91 9.0 25.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mucin PF01456.17 CDI85958.1 - 0.67 9.9 36.2 1.9 8.5 13.0 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein SART-1 PF03343.13 CDI85958.1 - 0.75 8.3 17.6 1.1 7.8 17.6 1.2 1 0 0 1 1 1 0 SART-1 family Connexin PF00029.19 CDI85958.1 - 1.6 8.4 8.0 2.4 7.9 8.0 1.3 1 0 0 1 1 1 0 Connexin RPA43_OB PF17875.1 CDI85958.1 - 1.9 9.1 11.1 0.29 11.8 6.4 1.9 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I RIFIN PF02009.16 CDI85958.1 - 2 8.2 30.9 3.4 7.5 30.3 1.5 1 1 0 1 1 1 0 Rifin CDV3 PF15359.6 CDI85958.1 - 2.3 8.7 14.3 0.25 11.9 9.6 1.8 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 Nha1_C PF08619.10 CDI85958.1 - 4.2 6.5 17.7 5.6 6.1 17.7 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Tic110 PF16940.5 CDI85958.1 - 5.3 5.4 19.5 0.092 11.2 5.6 2.2 2 0 0 2 2 2 0 Chloroplast envelope transporter DUF2347 PF09804.9 CDI85958.1 - 5.8 6.4 10.9 9.1 5.8 10.9 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Macoilin PF09726.9 CDI85958.1 - 9.8 4.6 29.0 12 4.3 29.0 1.1 1 0 0 1 1 1 0 Macoilin family RskA PF10099.9 CDI85959.1 - 1.6e-08 35.0 2.2 1.6e-08 35.0 2.2 3.7 1 1 2 3 3 3 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI85959.1 - 0.003 17.2 7.1 0.003 17.2 7.1 3.1 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein DUF3464 PF11947.8 CDI85959.1 - 0.0065 16.2 0.6 0.0065 16.2 0.6 3.6 2 1 1 3 3 3 1 Photosynthesis affected mutant 68 Spt20 PF12090.8 CDI85959.1 - 0.022 14.4 16.9 0.022 14.4 16.9 3.5 3 1 1 4 4 4 0 Spt20 family SART-1 PF03343.13 CDI85959.1 - 0.022 13.3 26.8 0.08 11.5 21.0 2.1 2 0 0 2 2 2 0 SART-1 family EPL1 PF10513.9 CDI85959.1 - 0.024 15.0 1.0 0.024 15.0 1.0 3.2 2 1 1 3 3 3 0 Enhancer of polycomb-like Cwf_Cwc_15 PF04889.12 CDI85960.1 - 0.00091 19.0 36.2 0.0012 18.7 36.2 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein BSP_II PF05432.11 CDI85960.1 - 0.022 14.5 30.5 0.027 14.2 30.5 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Shadoo PF14999.6 CDI85960.1 - 0.023 14.8 3.2 0.031 14.4 3.2 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective GRAS PF03514.14 CDI85960.1 - 0.22 10.5 3.0 0.29 10.0 3.0 1.1 1 0 0 1 1 1 0 GRAS domain family BUD22 PF09073.10 CDI85960.1 - 0.33 10.3 41.1 0.37 10.1 41.1 1.1 1 0 0 1 1 1 0 BUD22 SR-25 PF10500.9 CDI85960.1 - 0.46 10.1 46.7 1.2 8.7 19.4 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein ORC6 PF05460.13 CDI85960.1 - 0.54 9.5 20.9 0.59 9.4 20.9 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) PPP4R2 PF09184.11 CDI85960.1 - 0.87 9.1 33.2 1.2 8.7 33.2 1.2 1 0 0 1 1 1 0 PPP4R2 Na_trans_assoc PF06512.13 CDI85960.1 - 1.1 9.4 28.9 1.6 9.0 28.9 1.2 1 0 0 1 1 1 0 Sodium ion transport-associated DUF5521 PF17659.1 CDI85960.1 - 4.5 5.0 9.7 5.6 4.7 9.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5521) PNISR PF15996.5 CDI85960.1 - 5.8 7.1 35.0 5.2 7.3 34.3 1.3 1 1 0 1 1 1 0 Arginine/serine-rich protein PNISR TPR_1 PF00515.28 CDI85961.1 - 1.2e-08 34.4 0.0 3.2e-08 33.1 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDI85961.1 - 6.9e-06 25.9 0.0 2.1e-05 24.4 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDI85961.1 - 5.5e-05 23.0 0.0 5.5e-05 23.0 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDI85961.1 - 0.00078 19.7 0.0 0.0035 17.6 0.0 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI85961.1 - 0.004 17.9 0.0 0.051 14.4 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat GFO_IDH_MocA PF01408.22 CDI85961.1 - 0.0055 17.5 0.0 0.016 16.0 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold TPR_17 PF13431.6 CDI85961.1 - 0.017 15.5 0.1 1.1 9.8 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDI85961.1 - 0.092 12.5 0.1 0.24 11.1 0.1 1.7 1 0 0 1 1 1 0 TPR repeat Fis1_TPR_C PF14853.6 CDI85961.1 - 0.12 12.5 0.1 0.27 11.3 0.1 1.5 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 CDI85961.1 - 0.12 12.9 0.0 0.37 11.3 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat SOBP PF15279.6 CDI85964.1 - 7.5 7.1 55.9 13 6.3 55.9 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein SR-25 PF10500.9 CDI85965.1 - 0.00087 19.0 14.1 0.00087 19.0 14.1 2.0 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.19 CDI85966.1 - 0.014 15.9 5.8 0.014 15.9 5.8 10.4 6 2 3 9 9 9 0 60s Acidic ribosomal protein Pentapeptide_4 PF13599.6 CDI85967.1 - 0.41 10.9 4.3 1.4 9.2 4.2 1.9 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) CDC27 PF09507.10 CDI85968.1 - 4.1 6.7 13.8 5.1 6.4 13.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 FAM199X PF15814.5 CDI85968.1 - 6.2 5.8 13.2 7.3 5.5 13.2 1.2 1 0 0 1 1 1 0 Protein family FAM199X PP2C PF00481.21 CDI85971.1 - 2.2e-06 27.5 0.4 2.2e-06 27.5 0.4 3.5 2 1 1 3 3 3 1 Protein phosphatase 2C CobU PF02283.16 CDI85971.1 - 0.0051 16.4 6.2 0.068 12.7 0.8 3.2 2 0 0 2 2 2 2 Cobinamide kinase / cobinamide phosphate guanyltransferase RskA PF10099.9 CDI85971.1 - 0.0052 17.1 3.0 0.0052 17.1 3.0 10.5 2 1 7 9 9 9 4 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI85971.1 - 0.011 15.8 10.7 0.011 15.8 10.7 11.8 8 5 0 8 8 8 0 Unstructured region C-term to UIM in Ataxin3 DUF755 PF05501.11 CDI85972.1 - 7.7e-05 23.0 27.8 7.7e-05 23.0 27.8 5.9 2 1 2 4 4 4 2 Domain of unknown function (DUF755) PA PF02225.22 CDI85973.1 - 0.49 10.5 2.1 1.5 8.9 2.1 1.8 1 1 0 1 1 1 0 PA domain Utp14 PF04615.13 CDI85973.1 - 0.5 8.9 72.4 0.74 8.3 72.4 1.2 1 0 0 1 1 1 0 Utp14 protein RVT_1 PF00078.27 CDI85974.1 - 2.5e-14 53.4 0.0 4.1e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 CDI85974.1 - 7.1e-10 38.8 0.0 1.2e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 CDI85974.1 - 3.2e-08 34.0 0.0 6e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDI85974.1 - 2.7e-07 31.1 0.0 5.4e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 CDI85974.1 - 0.064 13.6 0.1 0.29 11.5 0.0 2.0 2 0 0 2 2 2 0 Retroviral aspartyl protease Chromo PF00385.24 CDI85976.1 - 5.9e-10 38.9 0.0 1.4e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF2303 PF10065.9 CDI85977.1 - 0.018 14.2 0.0 0.029 13.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2303) SIMPL PF04402.14 CDI85977.1 - 0.78 10.2 6.2 1.6 9.1 6.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF541) RPN6_N PF18055.1 CDI85978.1 - 0.012 15.9 0.1 0.27 11.6 0.1 2.6 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain Peptidase_M99_m PF17130.4 CDI85978.1 - 0.07 13.1 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 beta-barrel domain of carboxypeptidase M99 DUF2767 PF10965.8 CDI85978.1 - 0.081 12.9 0.0 5.7 7.0 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2767) Ribosomal_L12 PF00542.19 CDI85979.1 - 7e-20 71.1 2.1 7e-20 71.1 2.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 CDI85979.1 - 4.2e-15 55.2 2.9 4.2e-15 55.2 2.9 2.6 2 0 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain FAD_binding_3 PF01494.19 CDI85980.1 - 6.8e-42 144.0 0.8 3.1e-19 69.5 0.0 4.4 2 2 2 4 4 4 3 FAD binding domain Pyr_redox_3 PF13738.6 CDI85980.1 - 0.00078 18.8 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDI85980.1 - 0.0011 18.6 0.0 0.0022 17.6 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDI85980.1 - 0.0051 17.0 0.1 0.015 15.5 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CDI85980.1 - 0.095 11.9 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CDI85980.1 - 0.14 11.4 0.1 0.23 10.7 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Spt20 PF12090.8 CDI85980.1 - 8 6.0 8.8 14 5.2 8.8 1.3 1 0 0 1 1 1 0 Spt20 family SUV3_C PF12513.8 CDI85981.1 - 9.9e-12 44.6 0.7 2.4e-11 43.4 0.0 2.0 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 CDI85981.1 - 0.00032 21.0 0.0 0.0017 18.7 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain Suv3_C_1 PF18147.1 CDI85981.1 - 0.0013 18.6 0.2 0.0047 16.8 0.2 2.0 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 7TMR-HDED PF07697.11 CDI85981.1 - 0.013 15.7 0.9 0.042 14.0 0.9 1.8 1 0 0 1 1 1 0 7TM-HD extracellular BTB_2 PF02214.22 CDI85982.1 - 4e-14 52.7 0.0 9.1e-14 51.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain DUF2477 PF10631.9 CDI85982.1 - 0.01 16.5 17.0 0.01 16.5 17.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2477) Methyltr_RsmB-F PF01189.17 CDI85984.1 - 5.9e-23 81.6 0.1 2.3e-15 56.8 0.0 2.2 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 CDI85984.1 - 0.029 14.5 0.0 0.094 12.8 0.0 1.9 1 1 0 1 1 1 0 FtsJ-like methyltransferase Rab_bind PF16704.5 CDI85985.1 - 0.016 15.2 2.9 0.042 13.9 2.9 1.8 1 0 0 1 1 1 0 Rab binding domain DUF5497 PF17601.2 CDI85985.1 - 0.065 13.6 0.3 0.16 12.3 0.3 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5497) 2-Hacid_dh PF00389.30 CDI85985.1 - 1.7 8.3 4.3 1 9.0 1.6 2.1 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain TetR_C_24 PF17932.1 CDI85985.1 - 7 7.0 17.7 0.59 10.4 2.0 3.1 1 1 2 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Muted PF14942.6 CDI85985.1 - 9.4 6.6 24.6 5.8 7.3 11.7 2.5 1 1 2 3 3 3 0 Organelle biogenesis, Muted-like protein SR-25 PF10500.9 CDI85986.1 - 9.4e-06 25.4 1.1 1.1e-05 25.2 1.1 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI85986.1 - 0.00052 20.7 3.4 0.00052 20.7 3.4 1.8 2 0 0 2 2 2 1 Immortalisation up-regulated protein DUF3573 PF12097.8 CDI85986.1 - 0.02 13.8 5.6 0.024 13.5 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) CCDC106 PF15794.5 CDI85986.1 - 0.12 12.0 7.4 0.17 11.5 7.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 PRKG1_interact PF15898.5 CDI85986.1 - 0.17 12.8 8.1 0.29 12.0 8.1 1.4 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Presenilin PF01080.17 CDI85986.1 - 0.19 10.5 2.7 0.19 10.4 2.7 1.1 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 CDI85986.1 - 0.22 11.1 17.4 0.26 10.9 17.4 1.3 1 1 0 1 1 1 0 Spt20 family Jnk-SapK_ap_N PF09744.9 CDI85986.1 - 0.31 11.3 8.8 0.44 10.8 8.8 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Chorion_2 PF03964.15 CDI85986.1 - 2.2 9.2 7.7 3 8.7 1.0 2.2 2 0 0 2 2 2 0 Chorion family 2 RAP1 PF07218.11 CDI85986.1 - 2.5 6.3 6.0 3.3 5.9 6.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CDK2AP PF09806.9 CDI85986.1 - 3.2 7.8 12.2 3 7.8 5.4 2.1 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein SDP_N PF12278.8 CDI85986.1 - 3.6 7.7 9.9 6.1 7.0 9.9 1.3 1 0 0 1 1 1 0 Sex determination protein N terminal Lin-8 PF03353.15 CDI85986.1 - 3.7 7.0 11.7 1.3 8.5 9.3 1.5 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist EBP50_C PF09007.11 CDI85986.1 - 4.1 8.4 11.7 5.7 8.0 11.6 1.5 1 1 0 1 1 1 0 EBP50, C-terminal DUF740 PF05340.12 CDI85988.1 - 0.95 8.1 17.0 1.2 7.8 17.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF740) SMYLE_N PF18615.1 CDI85988.1 - 7.5 6.0 28.0 8.1 5.9 28.0 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain MID_MedPIWI PF18296.1 CDI85989.1 - 0.0071 16.2 9.7 0.0074 16.1 9.7 1.1 1 0 0 1 1 1 1 MID domain of medPIWI SPX PF03105.19 CDI85989.1 - 0.084 12.8 13.2 0.096 12.6 13.2 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI85989.1 - 0.091 11.6 15.3 0.12 11.3 15.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF572 PF04502.13 CDI85989.1 - 5.7 6.5 8.5 6.2 6.3 8.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) TFIIA PF03153.13 CDI85992.1 - 0.1 12.6 55.2 0.14 12.1 55.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3984 PF13136.6 CDI85992.1 - 0.11 11.9 16.0 0.13 11.7 16.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) Hamartin PF04388.12 CDI85992.1 - 0.51 8.9 22.2 0.6 8.7 22.2 1.0 1 0 0 1 1 1 0 Hamartin protein MAP7 PF05672.11 CDI85992.1 - 1.9 8.2 41.6 2.5 7.7 41.6 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family DUF1800 PF08811.11 CDI85992.1 - 3.5 6.5 21.4 5.5 5.9 21.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) LPMO_10 PF03067.15 CDI85992.1 - 5.3 7.6 22.1 6.8 7.3 22.1 1.1 1 0 0 1 1 1 0 Lytic polysaccharide mono-oxygenase, cellulose-degrading PAT1 PF09770.9 CDI85992.1 - 6.1 5.0 44.5 7.2 4.7 44.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Exonuc_VII_L PF02601.15 CDI85992.1 - 9.3 5.7 28.8 12 5.4 28.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit SR-25 PF10500.9 CDI85993.1 - 0.00072 19.2 0.8 0.0013 18.3 0.8 1.5 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein FliX PF10768.9 CDI85993.1 - 0.014 15.9 3.4 0.014 15.9 3.4 1.5 2 0 0 2 2 2 0 Class II flagellar assembly regulator TYW3 PF02676.14 CDI85993.1 - 0.02 14.2 0.2 0.031 13.6 0.2 1.3 1 0 0 1 1 1 0 Methyltransferase TYW3 Neur_chan_memb PF02932.16 CDI85993.1 - 0.035 14.2 0.9 0.048 13.7 0.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ExbD PF02472.16 CDI85993.1 - 0.22 11.7 3.8 0.088 13.0 1.1 1.7 2 0 0 2 2 2 0 Biopolymer transport protein ExbD/TolR RSF PF14876.6 CDI85993.1 - 1.4 7.8 9.8 0.14 11.1 3.0 2.0 2 0 0 2 2 2 0 Respiratory growth transcriptional regulator TMEM51 PF15345.6 CDI85993.1 - 2.2 8.1 9.5 0.27 11.0 4.0 1.8 1 1 0 2 2 2 0 Transmembrane protein 51 AAA_23 PF13476.6 CDI85993.1 - 5.3 7.5 8.3 9.5 6.7 8.3 1.4 1 0 0 1 1 1 0 AAA domain DUF3823_C PF18003.1 CDI85994.1 - 0.25 12.1 3.1 0.43 11.3 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3823_C) RskA PF10099.9 CDI85995.1 - 0.00036 20.9 4.7 0.00036 20.9 4.7 7.7 1 1 5 6 6 6 3 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI85995.1 - 0.0068 16.1 3.7 0.0068 16.1 3.7 5.1 4 1 0 4 4 4 3 Spt20 family DUF3915 PF13054.6 CDI85995.1 - 0.21 11.6 0.0 0.21 11.6 0.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF3915) Connexin PF00029.19 CDI85995.1 - 0.82 9.4 25.0 3.1 7.5 10.2 4.1 4 0 0 4 4 4 0 Connexin eIF-3_zeta PF05091.12 CDI85995.1 - 2.4 7.0 48.6 3.4 6.5 4.7 4.1 4 0 0 4 4 4 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2722 PF10846.8 CDI85996.1 - 0.0024 16.9 5.4 0.0024 16.9 5.4 3.0 2 1 0 2 2 2 1 Protein of unknown function (DUF2722) CNDH2_C PF16858.5 CDI85996.1 - 0.6 9.9 18.6 3.2 7.6 15.1 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF755 PF05501.11 CDI85996.1 - 0.83 9.9 49.8 0.4 11.0 33.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Apt1 PF10351.9 CDI85996.1 - 1.5 7.6 26.8 2.1 7.1 17.7 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain AF-4 PF05110.13 CDI85996.1 - 9.5 4.2 44.8 3.3 5.7 6.0 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Fib_alpha PF08702.10 CDI85997.1 - 0.0015 18.8 2.4 0.0015 18.8 2.4 2.9 2 1 0 2 2 2 1 Fibrinogen alpha/beta chain family Spc7 PF08317.11 CDI85997.1 - 0.0057 15.6 12.2 0.0057 15.6 12.2 2.1 1 1 1 2 2 2 1 Spc7 kinetochore protein DUF812 PF05667.11 CDI85997.1 - 0.006 15.5 12.2 0.006 15.5 12.2 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF812) COG6 PF06419.11 CDI85997.1 - 0.018 13.3 17.8 0.028 12.7 8.7 2.3 1 1 1 2 2 2 0 Conserved oligomeric complex COG6 DHR10 PF18595.1 CDI85997.1 - 0.027 14.5 9.0 0.027 14.5 9.0 3.4 1 1 1 3 3 3 0 Designed helical repeat protein 10 domain FliJ PF02050.16 CDI85997.1 - 0.032 14.5 6.3 0.032 14.5 6.3 3.2 1 1 1 3 3 3 0 Flagellar FliJ protein BRX_N PF13713.6 CDI85997.1 - 0.036 13.8 1.1 0.12 12.2 0.3 2.2 2 0 0 2 2 2 0 Transcription factor BRX N-terminal domain Filament PF00038.21 CDI85997.1 - 0.052 13.1 26.2 0.015 14.9 22.9 1.7 1 1 0 1 1 1 0 Intermediate filament protein TMF_TATA_bd PF12325.8 CDI85997.1 - 0.09 13.0 29.9 2.2 8.5 12.2 3.1 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Fez1 PF06818.15 CDI85997.1 - 0.15 12.5 28.2 0.16 12.4 27.4 1.5 1 1 0 1 1 1 0 Fez1 GAS PF13851.6 CDI85997.1 - 0.22 10.9 36.0 0.051 12.9 24.9 2.7 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ING PF12998.7 CDI85997.1 - 0.27 11.8 17.6 0.16 12.5 7.1 2.7 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Bcr-Abl_Oligo PF09036.10 CDI85997.1 - 0.56 10.3 10.0 0.75 9.8 0.4 3.3 2 1 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain NPV_P10 PF05531.12 CDI85997.1 - 0.57 10.7 11.9 1.9 9.0 2.2 3.0 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein ATG16 PF08614.11 CDI85997.1 - 0.6 10.3 31.2 0.057 13.6 15.9 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF724 PF05266.14 CDI85997.1 - 0.96 9.2 28.5 0.52 10.1 12.4 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF724) FUSC PF04632.12 CDI85997.1 - 1.1 7.7 3.5 1.2 7.6 3.5 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family UPF0242 PF06785.11 CDI85997.1 - 1.7 8.7 32.4 0.69 10.0 4.3 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus COG2 PF06148.11 CDI85997.1 - 2.2 8.4 16.1 2.8 8.0 1.0 3.2 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 BRE1 PF08647.11 CDI85997.1 - 2.7 8.1 36.0 3.8 7.6 2.4 4.1 1 1 3 4 4 4 0 BRE1 E3 ubiquitin ligase Atg14 PF10186.9 CDI85997.1 - 3.2 6.8 31.5 0.3 10.1 9.2 2.4 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 CDI85997.1 - 3.4 8.2 36.4 1.8 9.1 16.5 2.6 1 1 2 3 3 3 0 Apg6 coiled-coil region Vps51 PF08700.11 CDI85997.1 - 4 7.6 16.0 2.2 8.4 0.2 3.9 2 2 2 4 4 4 0 Vps51/Vps67 ADIP PF11559.8 CDI85997.1 - 5.4 7.1 35.2 0.58 10.2 6.0 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding End3 PF12761.7 CDI85997.1 - 5.6 7.1 25.0 4.5 7.4 0.8 2.5 2 1 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DUF1664 PF07889.12 CDI85997.1 - 6.2 6.9 20.4 0.14 12.2 8.6 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) GrpE PF01025.19 CDI85997.1 - 8.8 6.0 26.6 1 9.0 4.0 3.1 1 1 2 3 3 3 0 GrpE DUF4407 PF14362.6 CDI85997.1 - 9.3 5.5 26.4 4.1 6.7 22.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF2722 PF10846.8 CDI85998.1 - 8.3e-05 21.7 4.9 8.3e-05 21.7 4.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Med15 PF09606.10 CDI85998.1 - 0.0013 17.5 10.8 0.0013 17.5 10.8 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal ADH_N PF08240.12 CDI85998.1 - 0.0049 16.7 0.1 0.0098 15.8 0.0 1.5 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain TFIIA PF03153.13 CDI85998.1 - 0.011 15.7 8.6 0.011 15.7 8.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RcpC PF16976.5 CDI85998.1 - 0.014 15.4 2.7 0.018 15.1 2.7 1.2 1 0 0 1 1 1 0 Flp pilus assembly protein RcpC/CpaB Spt20 PF12090.8 CDI85998.1 - 0.032 13.9 15.0 0.036 13.7 15.0 1.1 1 0 0 1 1 1 0 Spt20 family DUF3371 PF11851.8 CDI85998.1 - 0.055 14.6 5.1 0.068 14.3 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Activator_LAG-3 PF11498.8 CDI85998.1 - 0.43 9.5 19.2 0.49 9.3 19.2 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF5349 PF17298.2 CDI85998.1 - 0.56 9.9 4.8 0.58 9.9 4.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5349) Androgen_recep PF02166.16 CDI85998.1 - 0.86 8.4 14.3 1 8.1 14.3 1.1 1 0 0 1 1 1 0 Androgen receptor Med3 PF11593.8 CDI85998.1 - 2.1 7.4 13.7 2.5 7.2 13.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Peptidase_C97 PF05903.14 CDI85999.1 - 3e-09 36.9 0.0 5.7e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain SARAF PF06682.12 CDI85999.1 - 6.2e-06 26.1 29.9 0.01 15.5 25.2 2.3 2 0 0 2 2 2 2 SOCE-associated regulatory factor of calcium homoeostasis DUF1645 PF07816.11 CDI85999.1 - 0.011 16.3 5.6 0.011 16.3 5.6 4.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1645) Med15 PF09606.10 CDI85999.1 - 0.033 12.9 26.6 0.058 12.1 26.6 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Filament_head PF04732.14 CDI85999.1 - 3 8.8 62.2 0.36 11.7 6.0 3.8 3 0 0 3 3 3 0 Intermediate filament head (DNA binding) region DUF2464 PF10240.9 CDI86000.1 - 0.01 15.4 4.7 0.01 15.4 4.7 4.3 4 0 0 4 4 4 0 Multivesicular body subunit 12 FHIPEP PF00771.20 CDI86000.1 - 0.11 10.9 14.9 0.19 10.1 3.3 3.3 3 0 0 3 3 3 0 FHIPEP family SID-1_RNA_chan PF13965.6 CDI86000.1 - 0.17 10.3 10.3 0.77 8.1 0.4 2.9 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 FAM76 PF16046.5 CDI86000.1 - 1.3 8.3 34.9 0.34 10.2 5.8 4.2 4 0 0 4 4 4 0 FAM76 protein Rxt3 PF08642.10 CDI86000.1 - 2.1 9.2 20.7 0.47 11.2 0.8 4.8 5 0 0 5 5 5 0 Histone deacetylation protein Rxt3 Band_3_cyto PF07565.13 CDI86000.1 - 5.7 6.7 34.2 1.1 9.0 6.2 4.2 4 0 0 4 4 4 0 Band 3 cytoplasmic domain FAM60A PF15396.6 CDI86000.1 - 7.6 6.5 32.5 0.89 9.5 4.9 4.2 4 0 0 4 4 4 0 Protein Family FAM60A CK1gamma_C PF12605.8 CDI86001.1 - 0.16 13.1 13.9 0.2 12.8 13.9 1.1 1 0 0 1 1 1 0 Casein kinase 1 gamma C terminal CKAP2_C PF15297.6 CDI86001.1 - 0.31 10.1 7.1 0.35 9.9 7.1 1.0 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus RR_TM4-6 PF06459.12 CDI86001.1 - 0.34 10.7 6.9 0.33 10.7 6.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pex14_N PF04695.13 CDI86001.1 - 0.42 11.3 16.2 0.48 11.1 16.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF533 PF04391.12 CDI86001.1 - 0.47 10.0 14.7 0.59 9.7 14.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF533) GNAT_like PF18407.1 CDI86001.1 - 0.64 10.4 7.3 6.1 7.3 1.0 2.2 1 1 1 2 2 2 0 GCN5-related N-acetyltransferase like domain EPL1 PF10513.9 CDI86001.1 - 1.1 9.6 9.9 1.3 9.4 9.9 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like MMR1 PF08505.10 CDI86001.1 - 1.2 9.4 11.8 1.5 9.1 11.8 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Suf PF05843.14 CDI86001.1 - 1.6 8.7 17.4 2 8.3 17.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PRC2_HTH_1 PF18118.1 CDI86001.1 - 1.6 9.6 6.7 2 9.2 6.7 1.2 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Lin-8 PF03353.15 CDI86001.1 - 2 7.9 14.2 2.3 7.7 14.2 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PepSY_TM PF03929.16 CDI86001.1 - 4.2 6.9 6.4 4.7 6.8 6.4 1.1 1 0 0 1 1 1 0 PepSY-associated TM region PAT1 PF09770.9 CDI86001.1 - 4.2 5.5 18.0 4.6 5.4 18.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EIIBC-GUT_N PF03612.14 CDI86001.1 - 4.3 7.0 7.0 4.8 6.9 7.0 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 CDI86001.1 - 6 5.5 13.0 6.6 5.4 13.0 1.0 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI86001.1 - 6.2 6.7 27.3 7.1 6.5 27.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI86001.1 - 6.7 6.3 30.2 7.9 6.0 30.2 1.1 1 0 0 1 1 1 0 Spt20 family CPSF100_C PF13299.6 CDI86001.1 - 6.9 6.8 8.8 8 6.6 8.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Band_3_cyto PF07565.13 CDI86001.1 - 7.2 6.3 9.8 7.6 6.2 9.8 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CCDC53 PF10152.9 CDI86001.1 - 7.6 6.9 11.6 9.2 6.7 11.6 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Shisa PF13908.6 CDI86002.1 - 0.0016 18.7 3.9 0.0016 18.7 3.9 7.8 7 2 1 8 8 8 1 Wnt and FGF inhibitory regulator DUF2722 PF10846.8 CDI86002.1 - 0.0034 16.4 16.2 0.0034 16.4 16.2 8.7 6 2 1 7 7 7 1 Protein of unknown function (DUF2722) S4 PF01479.25 CDI86002.1 - 0.016 14.9 0.1 0.039 13.7 0.1 1.6 1 0 0 1 1 1 0 S4 domain PAT1 PF09770.9 CDI86002.1 - 0.93 7.7 90.3 0.082 11.2 11.9 3.6 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 Apt1 PF10351.9 CDI86002.1 - 5.1 5.8 56.8 0.63 8.8 9.6 5.2 4 1 0 4 4 4 0 Golgi-body localisation protein domain NUDIX PF00293.28 CDI86003.1 - 9.1e-14 51.6 0.0 1.6e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain DUF2722 PF10846.8 CDI86003.1 - 7.7e-06 25.1 2.1 7.7e-06 25.1 2.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) MecA PF05389.12 CDI86003.1 - 0.0011 18.7 0.7 0.63 9.6 0.1 2.1 2 0 0 2 2 2 2 Negative regulator of genetic competence (MecA) Presenilin PF01080.17 CDI86003.1 - 0.0021 16.9 3.2 0.0041 15.9 3.3 1.3 1 1 0 1 1 1 1 Presenilin DUF2828 PF11443.8 CDI86003.1 - 0.0051 15.0 0.6 0.007 14.5 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) Ketoacyl-synt_2 PF13723.6 CDI86003.1 - 0.0054 16.4 10.3 0.19 11.4 2.4 2.1 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain DUF4834 PF16118.5 CDI86003.1 - 0.0059 17.6 10.7 0.19 12.7 0.2 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) TFIIA PF03153.13 CDI86003.1 - 0.013 15.5 9.5 0.013 15.5 9.5 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit CPSF100_C PF13299.6 CDI86003.1 - 0.019 15.1 2.9 3.2 7.9 0.8 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RskA PF10099.9 CDI86003.1 - 0.021 15.1 11.8 1.2 9.5 6.2 2.2 1 1 0 2 2 2 0 Anti-sigma-K factor rskA Orf78 PF06024.12 CDI86003.1 - 0.043 14.1 4.5 1.4 9.2 0.2 2.2 2 0 0 2 2 2 0 Orf78 (ac78) FHIPEP PF00771.20 CDI86003.1 - 0.045 12.2 5.5 0.8 8.1 0.8 2.0 2 0 0 2 2 2 0 FHIPEP family DUF4079 PF13301.6 CDI86003.1 - 0.084 13.0 1.0 2.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) Connexin PF00029.19 CDI86003.1 - 0.1 12.3 4.2 2 8.1 0.2 2.1 2 0 0 2 2 2 0 Connexin Nuf2 PF03800.14 CDI86003.1 - 0.11 12.6 5.1 1.5 8.9 1.1 2.1 2 0 0 2 2 2 0 Nuf2 family Thg1C PF14413.6 CDI86003.1 - 0.12 12.6 6.3 3.1 8.0 1.4 2.2 2 0 0 2 2 2 0 Thg1 C terminal domain Med15 PF09606.10 CDI86003.1 - 0.12 11.1 34.5 0.026 13.2 10.3 2.0 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Gaa1 PF04114.14 CDI86003.1 - 0.12 11.4 2.0 4.3 6.2 0.0 2.1 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component Spore_YhcN_YlaJ PF09580.10 CDI86003.1 - 0.12 12.4 6.6 2.2 8.4 0.0 2.1 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Spt20 PF12090.8 CDI86003.1 - 0.14 11.8 38.5 0.056 13.0 11.2 2.1 2 0 0 2 2 2 0 Spt20 family DUF3499 PF12005.8 CDI86003.1 - 0.14 12.8 5.5 4.4 7.9 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3499) Hydin_ADK PF17213.3 CDI86003.1 - 0.2 11.9 6.0 1.4 9.1 0.6 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain CAF1 PF04857.20 CDI86003.1 - 0.22 10.7 3.7 0.45 9.6 3.8 1.4 1 1 0 1 1 1 0 CAF1 family ribonuclease DUF4746 PF15928.5 CDI86003.1 - 0.24 10.8 4.1 1.6 8.1 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) HA2 PF04408.23 CDI86003.1 - 0.25 11.7 4.1 9.2 6.6 1.5 2.2 2 0 0 2 2 2 0 Helicase associated domain (HA2) GBP_C PF02841.14 CDI86003.1 - 0.29 10.5 19.8 0.28 10.6 7.7 2.1 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain Sox_N PF12444.8 CDI86003.1 - 0.29 12.3 3.3 0.92 10.7 0.1 2.3 2 0 0 2 2 2 0 Sox developmental protein N terminal DUF5327 PF17261.2 CDI86003.1 - 0.34 11.7 18.0 2.8 8.8 5.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5327) CDRT4 PF15213.6 CDI86003.1 - 0.37 11.4 2.8 3.8 8.1 0.2 2.2 2 0 0 2 2 2 0 CMT1A duplicated region transcript 4 protein Eapp_C PF10238.9 CDI86003.1 - 0.38 10.8 11.1 1.1 9.3 1.7 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF1840 PF08895.11 CDI86003.1 - 0.43 10.9 14.0 2.7 8.4 4.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) EIIBC-GUT_N PF03612.14 CDI86003.1 - 0.45 10.2 8.8 1.2 8.9 0.6 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus CLN3 PF02487.17 CDI86003.1 - 0.55 9.2 4.4 6.1 5.8 0.2 2.1 2 0 0 2 2 2 0 CLN3 protein HbrB PF08539.11 CDI86003.1 - 0.59 10.1 5.4 7.6 6.5 0.2 2.2 2 0 0 2 2 2 0 HbrB-like DUF3464 PF11947.8 CDI86003.1 - 0.65 9.7 9.6 2.5 7.8 1.4 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 ALMT PF11744.8 CDI86003.1 - 0.66 8.7 4.1 3.2 6.5 0.2 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter CTU2 PF10288.9 CDI86003.1 - 0.7 10.2 10.1 0.82 9.9 1.0 2.2 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Peptidase_S49_N PF08496.10 CDI86003.1 - 0.7 9.9 8.7 2.9 8.0 1.7 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4457 PF14652.6 CDI86003.1 - 0.71 9.1 5.7 1.7 7.8 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4457) Peroxin-13_N PF04088.13 CDI86003.1 - 0.73 10.1 4.5 15 5.8 0.8 2.2 2 0 0 2 2 2 0 Peroxin 13, N-terminal region TERB2 PF15101.6 CDI86003.1 - 0.75 9.8 15.9 3 7.8 3.3 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Dynamin_N PF00350.23 CDI86003.1 - 0.76 9.8 4.0 11 6.0 0.5 2.1 2 0 0 2 2 2 0 Dynamin family BRF1 PF07741.13 CDI86003.1 - 0.8 10.1 9.9 1.1 9.6 0.2 2.3 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF1418 PF07214.12 CDI86003.1 - 0.83 9.5 3.7 2.5 8.0 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) Ipi1_N PF12333.8 CDI86003.1 - 0.86 10.2 4.9 4.8 7.8 0.4 2.2 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation FTO_NTD PF12933.7 CDI86003.1 - 0.89 8.7 7.0 0.56 9.4 0.7 2.1 2 0 0 2 2 2 0 FTO catalytic domain DUF4628 PF15429.6 CDI86003.1 - 0.98 9.0 10.3 3.7 7.1 2.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4628) MCU PF04678.13 CDI86003.1 - 1.1 9.4 8.6 2 8.5 2.6 2.1 2 0 0 2 2 2 0 Mitochondrial calcium uniporter PRC2_HTH_1 PF18118.1 CDI86003.1 - 1.1 10.1 6.4 4.2 8.2 0.4 2.2 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Helicase_RecD PF05127.14 CDI86003.1 - 1.1 9.1 4.9 6.7 6.5 0.2 2.1 2 0 0 2 2 2 0 Helicase EPL1 PF10513.9 CDI86003.1 - 1.2 9.6 12.4 3 8.2 2.7 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF719 PF05334.13 CDI86003.1 - 1.2 9.3 11.7 5.1 7.2 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF719) Pex26 PF07163.12 CDI86003.1 - 1.3 8.3 17.3 2.1 7.6 4.7 2.2 2 0 0 2 2 2 0 Pex26 protein Pet20 PF08692.10 CDI86003.1 - 1.3 9.7 3.9 22 5.8 0.6 2.2 2 0 0 2 2 2 0 Mitochondrial protein Pet20 Suf PF05843.14 CDI86003.1 - 1.3 8.9 21.3 1.5 8.7 6.0 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) AIF_C PF14721.6 CDI86003.1 - 1.4 9.3 7.7 9.1 6.7 0.3 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term ST7 PF04184.12 CDI86003.1 - 1.5 7.2 7.9 0.027 13.0 0.7 1.6 2 0 0 2 2 2 0 ST7 protein Conotoxin PF02950.17 CDI86003.1 - 1.8 9.6 12.9 4.2 8.5 3.8 2.3 2 0 0 2 2 2 0 Conotoxin Pap_E4 PF02711.14 CDI86003.1 - 1.8 9.6 11.2 2.3 9.2 2.1 2.2 2 0 0 2 2 2 0 E4 protein Sec62 PF03839.16 CDI86003.1 - 1.9 7.9 8.7 1.7 8.1 1.8 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 PigN PF04987.14 CDI86003.1 - 2.2 7.1 7.7 3.7 6.3 1.3 2.1 2 0 0 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) PCYCGC PF13798.6 CDI86003.1 - 2.4 8.0 6.5 0.67 9.8 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function with PCYCGC motif ANAPC_CDC26 PF10471.9 CDI86003.1 - 2.5 9.0 39.6 4.5 8.2 16.4 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 ORC5_C PF14630.6 CDI86003.1 - 2.5 7.5 8.3 1.1 8.7 0.8 2.1 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus RR_TM4-6 PF06459.12 CDI86003.1 - 2.8 7.7 9.6 3.6 7.3 1.8 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Holin_2-3 PF13272.6 CDI86003.1 - 2.9 8.2 4.4 2.7 8.3 0.4 2.3 2 0 0 2 2 2 0 Putative 2/3 transmembrane domain holin Pex14_N PF04695.13 CDI86003.1 - 3.1 8.4 21.4 2.2 8.9 4.7 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region V_ATPase_I PF01496.19 CDI86003.1 - 3.6 5.4 9.3 2 6.2 0.5 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF1676 PF07898.13 CDI86003.1 - 4.2 7.4 6.2 3.2 7.8 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) CagX PF03524.15 CDI86003.1 - 4.5 6.9 8.9 3.3 7.4 1.5 2.1 2 0 0 2 2 2 0 Conjugal transfer protein RAB3GAP2_N PF14655.6 CDI86003.1 - 5 6.3 11.7 6.3 6.0 3.0 2.1 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus OATP PF03137.20 CDI86003.1 - 5.3 5.2 6.0 9.8 4.3 0.3 2.0 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF2126 PF09899.9 CDI86003.1 - 5.4 5.0 8.0 1.2 7.1 1.2 2.0 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) TMEM51 PF15345.6 CDI86003.1 - 5.5 6.8 15.6 3.1 7.6 3.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 Spore_III_AF PF09581.10 CDI86003.1 - 6.4 6.8 12.9 7.1 6.6 0.2 2.2 2 0 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) Spore_coat_CotO PF14153.6 CDI86003.1 - 7.1 6.5 19.7 4.9 7.0 6.0 2.2 2 0 0 2 2 2 0 Spore coat protein CotO DUF775 PF05603.12 CDI86003.1 - 7.2 6.1 15.6 3.6 7.1 3.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF775) eIF-3_zeta PF05091.12 CDI86003.1 - 7.3 5.4 16.1 2.8 6.8 3.4 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GET2 PF08690.10 CDI86003.1 - 7.4 6.2 13.5 2.8 7.5 2.2 2.1 2 0 0 2 2 2 0 GET complex subunit GET2 dsDNA_bind PF01984.20 CDI86003.1 - 7.4 6.9 33.1 2.7 8.3 11.3 2.2 2 0 0 2 2 2 0 Double-stranded DNA-binding domain Spem1 PF15670.5 CDI86003.1 - 8.9 5.8 14.8 1.6 8.2 3.4 2.1 2 0 0 2 2 2 0 Spermatid maturation protein 1 FYDLN_acid PF09538.10 CDI86003.1 - 8.9 7.0 9.3 9.5 7.0 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) UPF0560 PF10577.9 CDI86003.1 - 9.2 4.6 20.2 2.5 6.5 5.9 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 DUF2489 PF10675.9 CDI86003.1 - 9.4 6.2 23.5 6 6.8 6.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) DUF3371 PF11851.8 CDI86003.1 - 10 7.3 17.5 1.3 10.1 2.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) DUF5102 PF17104.5 CDI86004.1 - 0.0014 18.8 1.3 0.0015 18.6 1.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) CIAPIN1 PF05093.13 CDI86004.1 - 0.0033 17.9 3.0 0.0039 17.7 3.0 1.1 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis CobT PF06213.12 CDI86004.1 - 0.013 14.9 9.0 0.015 14.7 9.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pex14_N PF04695.13 CDI86004.1 - 0.034 14.8 5.0 0.038 14.6 5.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4834 PF16118.5 CDI86004.1 - 0.035 15.1 2.6 0.041 14.9 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CSG2 PF16965.5 CDI86004.1 - 0.052 12.5 0.5 0.059 12.3 0.5 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator WBP-1 PF11669.8 CDI86004.1 - 0.065 13.9 2.8 0.088 13.4 2.8 1.2 1 0 0 1 1 1 0 WW domain-binding protein 1 Cellulose_synt PF03552.14 CDI86004.1 - 0.13 10.7 0.4 0.12 10.8 0.4 1.0 1 0 0 1 1 1 0 Cellulose synthase AIF_C PF14721.6 CDI86004.1 - 0.23 11.8 2.5 0.27 11.6 2.5 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Med15 PF09606.10 CDI86004.1 - 0.3 9.7 13.5 0.31 9.7 13.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Coilin_N PF15862.5 CDI86004.1 - 0.36 10.6 9.0 0.45 10.3 9.0 1.1 1 0 0 1 1 1 0 Coilin N-terminus Spt20 PF12090.8 CDI86004.1 - 0.37 10.4 19.3 0.44 10.1 19.3 1.1 1 0 0 1 1 1 0 Spt20 family Serinc PF03348.15 CDI86004.1 - 0.51 9.2 3.1 0.57 9.0 3.1 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2722 PF10846.8 CDI86004.1 - 0.64 8.9 17.3 0.7 8.8 17.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) UPF0560 PF10577.9 CDI86004.1 - 0.71 8.3 8.3 0.72 8.3 8.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Presenilin PF01080.17 CDI86004.1 - 0.81 8.4 6.4 0.92 8.2 6.4 1.0 1 0 0 1 1 1 0 Presenilin Sox_N PF12444.8 CDI86004.1 - 0.94 10.7 6.9 1.2 10.3 6.9 1.1 1 0 0 1 1 1 0 Sox developmental protein N terminal Neur_chan_memb PF02932.16 CDI86004.1 - 1.7 8.7 3.9 1.8 8.6 3.9 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Roughex PF06020.11 CDI86004.1 - 3.4 6.7 12.3 3.5 6.6 12.3 1.0 1 0 0 1 1 1 0 Drosophila roughex protein Med3 PF11593.8 CDI86004.1 - 9.4 5.3 16.7 10 5.2 16.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Solute_trans_a PF03619.16 CDI86005.1 - 2.5e-36 125.6 10.3 1.4e-28 100.2 1.0 3.2 2 1 1 3 3 3 3 Organic solute transporter Ostalpha Inhibitor_I71 PF12628.7 CDI86005.1 - 7.6 6.4 6.7 0.19 11.5 0.4 1.5 2 0 0 2 2 2 0 Falstatin, cysteine peptidase inhibitor AF-4 PF05110.13 CDI86006.1 - 0.00015 20.1 27.0 0.00019 19.7 27.0 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein polyprenyl_synt PF00348.17 CDI86006.1 - 0.05 12.7 4.9 0.096 11.7 4.9 1.5 1 0 0 1 1 1 0 Polyprenyl synthetase RAP1 PF07218.11 CDI86006.1 - 0.17 10.1 12.0 0.22 9.8 12.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SARAF PF06682.12 CDI86006.1 - 0.27 10.9 20.5 0.26 10.9 10.9 2.1 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis BSP_II PF05432.11 CDI86006.1 - 0.81 9.3 7.6 1.2 8.8 7.6 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) GET2 PF08690.10 CDI86006.1 - 2.7 7.6 28.1 2.6 7.6 15.4 2.1 2 0 0 2 2 2 0 GET complex subunit GET2 Miga PF10265.9 CDI86006.1 - 3 6.7 13.4 5.1 6.0 13.4 1.4 1 0 0 1 1 1 0 Mitoguardin SOG2 PF10428.9 CDI86006.1 - 4 6.5 28.3 5.3 6.1 28.3 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein PA26 PF04636.13 CDI86006.1 - 5.4 5.8 11.3 0.84 8.5 7.6 1.5 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) SART-1 PF03343.13 CDI86006.1 - 6 5.3 21.5 9.2 4.7 21.5 1.4 1 1 0 1 1 1 0 SART-1 family MS_channel PF00924.18 CDI86007.1 - 1.1e-11 44.7 1.6 1.5e-11 44.2 1.6 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_8 PF13833.6 CDI86007.1 - 0.18 11.6 0.1 0.41 10.5 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain pair LMBR1 PF04791.16 CDI86009.1 - 1.5 7.6 7.1 1.7 7.5 7.1 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein YajC PF02699.15 CDI86010.1 - 0.97 9.4 5.1 2.7 8.0 5.1 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit Spt20 PF12090.8 CDI86010.1 - 9.4 5.8 15.2 0.098 12.3 3.4 2.8 3 0 0 3 3 3 0 Spt20 family FUSC PF04632.12 CDI86011.1 - 3 6.3 25.6 4 5.9 25.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family RskA PF10099.9 CDI86012.1 - 0.032 14.5 29.1 1 9.6 22.8 2.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF1980 PF09323.10 CDI86012.1 - 0.72 9.7 7.0 0.54 10.1 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Spt20 PF12090.8 CDI86012.1 - 0.93 9.1 32.6 1.1 8.8 6.2 2.0 2 0 0 2 2 2 0 Spt20 family DUF5585 PF17823.1 CDI86012.1 - 1.5 7.7 17.4 1.8 7.4 17.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) DUF3464 PF11947.8 CDI86012.1 - 2.2 8.0 9.6 0.6 9.9 0.7 2.1 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DUF4834 PF16118.5 CDI86012.1 - 4.9 8.2 14.2 1.6 9.8 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Spt5_N PF11942.8 CDI86012.1 - 5.5 8.0 10.2 3.5 8.7 3.6 2.1 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal DUF677 PF05055.12 CDI86012.1 - 5.6 5.7 9.4 12 4.7 9.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF677) EPL1 PF10513.9 CDI86012.1 - 9.4 6.6 10.8 6.2 7.2 1.4 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like SUIM_assoc PF16619.5 CDI86013.1 - 0.004 17.2 0.6 0.004 17.2 0.6 6.1 6 1 1 7 7 7 2 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI86014.1 - 0.016 14.9 19.7 0.016 14.8 19.7 1.0 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI86014.1 - 0.048 13.7 14.7 0.048 13.6 14.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Usp PF00582.26 CDI86014.1 - 0.28 11.7 0.5 0.31 11.5 0.5 1.0 1 0 0 1 1 1 0 Universal stress protein family DUF3408 PF11888.8 CDI86014.1 - 0.35 11.0 7.1 0.35 11.0 7.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF4834 PF16118.5 CDI86014.1 - 0.44 11.5 8.8 0.5 11.4 8.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3464 PF11947.8 CDI86014.1 - 0.51 10.1 7.4 0.6 9.8 7.4 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Presenilin PF01080.17 CDI86014.1 - 0.75 8.5 5.4 0.74 8.5 5.4 1.0 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 CDI86014.1 - 1.1 8.2 8.4 1.1 8.1 8.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CobT PF06213.12 CDI86014.1 - 1.3 8.3 10.1 1.5 8.2 10.1 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2722 PF10846.8 CDI86014.1 - 1.4 7.8 20.3 1.5 7.7 20.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TERB2 PF15101.6 CDI86014.1 - 1.9 8.5 9.0 2.2 8.3 9.0 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 UPF0560 PF10577.9 CDI86014.1 - 2.2 6.7 10.0 2.2 6.7 10.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Roughex PF06020.11 CDI86014.1 - 6.6 5.7 14.0 7.4 5.6 14.0 1.1 1 0 0 1 1 1 0 Drosophila roughex protein DivIC PF04977.15 CDI86014.1 - 6.8 6.5 12.1 8.4 6.2 12.1 1.1 1 0 0 1 1 1 0 Septum formation initiator Suf PF05843.14 CDI86014.1 - 9.4 6.1 10.7 10 6.0 10.7 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MecA PF05389.12 CDI86015.1 - 0.28 10.8 16.0 0.35 10.4 16.0 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF3381 PF11861.8 CDI86015.1 - 0.46 10.3 28.0 0.49 10.2 28.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) TFB6 PF17110.5 CDI86015.1 - 0.96 9.2 11.6 0.95 9.2 11.6 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH AIF_C PF14721.6 CDI86015.1 - 0.97 9.8 12.5 1.1 9.6 12.5 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term EIIBC-GUT_N PF03612.14 CDI86015.1 - 1.2 8.9 15.6 1.3 8.7 15.6 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus SpoIIP PF07454.11 CDI86015.1 - 1.4 8.3 18.3 1.4 8.3 18.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Peroxin-13_N PF04088.13 CDI86015.1 - 1.4 9.2 10.0 1.4 9.2 10.0 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Dala_Dala_lig_N PF01820.21 CDI86015.1 - 1.7 9.1 4.4 2.1 8.8 4.4 1.3 1 0 0 1 1 1 0 D-ala D-ala ligase N-terminus PEX11 PF05648.14 CDI86015.1 - 1.9 7.9 11.0 2.3 7.6 11.0 1.3 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) CPSF100_C PF13299.6 CDI86015.1 - 2.4 8.3 14.3 2.7 8.1 14.3 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal NinG PF05766.12 CDI86015.1 - 2.4 8.1 22.8 2.6 7.9 22.8 1.2 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein Connexin PF00029.19 CDI86015.1 - 2.5 7.8 15.0 2.8 7.6 15.0 1.1 1 0 0 1 1 1 0 Connexin Pex14_N PF04695.13 CDI86015.1 - 2.6 8.7 26.2 3 8.5 26.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FHIPEP PF00771.20 CDI86015.1 - 3.2 6.1 11.6 2.9 6.2 11.6 1.0 1 0 0 1 1 1 0 FHIPEP family CBP_BcsG PF11658.8 CDI86015.1 - 3.5 5.9 17.4 3.6 5.9 17.4 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG FAM91_C PF14648.6 CDI86015.1 - 3.6 6.3 10.9 3.7 6.3 10.9 1.0 1 0 0 1 1 1 0 FAM91 C-terminus CD20 PF04103.15 CDI86015.1 - 3.8 7.6 4.1 4.4 7.4 4.1 1.1 1 0 0 1 1 1 0 CD20-like family TCP PF03634.13 CDI86015.1 - 4.3 7.9 24.3 4.5 7.8 24.3 1.0 1 0 0 1 1 1 0 TCP family transcription factor GOLD_2 PF13897.6 CDI86015.1 - 4.3 7.8 6.0 4.6 7.7 6.0 1.1 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF5308 PF17233.2 CDI86015.1 - 4.6 7.5 15.4 5.2 7.3 15.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) CobT PF06213.12 CDI86015.1 - 4.7 6.5 26.0 4.9 6.5 26.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM176 PF14851.6 CDI86015.1 - 5 6.8 13.9 5.3 6.7 13.9 1.2 1 0 0 1 1 1 0 FAM176 family K_trans PF02705.16 CDI86015.1 - 5.1 5.5 4.8 5 5.5 4.8 1.0 1 0 0 1 1 1 0 K+ potassium transporter DUF4746 PF15928.5 CDI86015.1 - 5.1 6.4 13.1 5.6 6.3 13.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Plexin_cytopl PF08337.12 CDI86015.1 - 5.7 5.5 16.9 5.7 5.5 16.9 1.0 1 0 0 1 1 1 0 Plexin cytoplasmic RasGAP domain Serinc PF03348.15 CDI86015.1 - 6.5 5.6 12.9 6.5 5.6 12.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4518 PF15008.6 CDI86015.1 - 6.8 5.8 18.6 7.3 5.7 18.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) Ketoacyl-synt_2 PF13723.6 CDI86015.1 - 7 6.2 19.1 7.5 6.1 19.1 1.0 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain CDC45 PF02724.14 CDI86015.1 - 7.6 4.7 21.6 7.9 4.6 21.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Peptidase_U57 PF05582.12 CDI86015.1 - 8.1 5.6 14.0 8.3 5.6 14.0 1.1 1 0 0 1 1 1 0 YabG peptidase U57 DDHD PF02862.17 CDI86015.1 - 8.7 6.4 17.4 9.8 6.3 17.4 1.1 1 0 0 1 1 1 0 DDHD domain Folate_carrier PF01770.18 CDI86015.1 - 9 4.9 11.9 9.5 4.8 11.9 1.0 1 0 0 1 1 1 0 Reduced folate carrier Ureide_permease PF07168.11 CDI86015.1 - 9.3 4.9 9.0 9.6 4.8 9.0 1.0 1 0 0 1 1 1 0 Ureide permease PTPRCAP PF15713.5 CDI86015.1 - 9.3 6.5 20.6 11 6.3 20.6 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RNA_capsid PF03035.14 CDI86016.1 - 0.01 15.9 2.2 0.012 15.7 2.2 1.1 1 0 0 1 1 1 1 Calicivirus putative RNA polymerase/capsid protein ABC2_membrane_3 PF12698.7 CDI86016.1 - 0.18 10.8 0.1 0.2 10.7 0.1 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein TCP PF03634.13 CDI86019.1 - 0.31 11.6 41.7 2 9.0 9.3 3.3 3 0 0 3 3 3 0 TCP family transcription factor SLX9 PF15341.6 CDI86019.1 - 1.2 9.5 41.4 1.7 9.0 10.2 3.3 3 0 0 3 3 3 0 Ribosome biogenesis protein SLX9 SR-25 PF10500.9 CDI86019.1 - 3.2 7.3 48.7 0.3 10.7 15.7 3.4 3 1 0 3 3 3 0 Nuclear RNA-splicing-associated protein DUF4050 PF13259.6 CDI86019.1 - 3.3 8.0 36.6 1.3 9.3 6.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4050) PTPRCAP PF15713.5 CDI86019.1 - 3.4 8.0 35.9 1.2 9.4 0.9 3.4 3 0 0 3 3 3 0 Protein tyrosine phosphatase receptor type C-associated MFAP1 PF06991.11 CDI86019.1 - 6.7 6.5 40.4 4 7.2 8.7 3.3 3 0 0 3 3 3 0 Microfibril-associated/Pre-mRNA processing Na_Ca_ex PF01699.24 CDI86020.1 - 1.9e-34 118.8 36.0 1.6e-21 76.8 18.8 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Med15 PF09606.10 CDI86021.1 - 8.2 5.0 62.8 10 4.7 62.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal LSM PF01423.22 CDI86022.1 - 1.7e-14 53.2 0.2 1.8e-14 53.1 0.2 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDI86022.1 - 0.00028 21.0 0.2 0.00054 20.0 0.2 1.5 1 1 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 CDI86022.1 - 0.025 14.7 0.1 0.25 11.5 0.1 2.1 1 1 0 1 1 1 0 Scd6-like Sm domain DUF2642 PF10842.8 CDI86022.1 - 0.046 13.6 0.1 0.091 12.6 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2642) RskA PF10099.9 CDI86023.1 - 0.39 11.0 45.4 13 6.1 45.4 2.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA OATP PF03137.20 CDI86023.1 - 0.78 8.0 8.5 1.2 7.3 8.5 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SID-1_RNA_chan PF13965.6 CDI86023.1 - 0.84 8.0 6.2 0.77 8.1 6.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 eIF-3_zeta PF05091.12 CDI86023.1 - 0.9 8.4 22.8 0.96 8.3 22.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AAA_23 PF13476.6 CDI86023.1 - 1.1 9.7 19.6 1.3 9.5 19.6 1.4 1 0 0 1 1 1 0 AAA domain BAF1_ABF1 PF04684.13 CDI86023.1 - 2.3 7.2 25.1 3.6 6.5 25.1 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SprA-related PF12118.8 CDI86023.1 - 4.2 6.4 46.6 6.2 5.9 46.6 1.3 1 0 0 1 1 1 0 SprA-related family PAT1 PF09770.9 CDI86023.1 - 4.4 5.4 37.9 4.9 5.3 37.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MDM10 PF12519.8 CDI86023.1 - 5.7 5.7 16.7 2.5 6.9 14.8 1.4 1 1 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SART-1 PF03343.13 CDI86023.1 - 9.8 4.6 29.8 11 4.4 29.8 1.1 1 0 0 1 1 1 0 SART-1 family Shisa PF13908.6 CDI86024.1 - 2.8 8.1 18.2 4.4 7.5 18.2 1.3 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator Di19_C PF14571.6 CDI86025.1 - 0.0044 17.5 0.4 0.0044 17.5 0.4 2.8 2 1 1 3 3 3 1 Stress-induced protein Di19, C-terminal Mlh1_C PF16413.5 CDI86025.1 - 0.012 15.0 2.1 0.012 15.0 2.1 2.3 2 1 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus PcfK PF14058.6 CDI86025.1 - 0.034 14.4 5.5 0.034 14.4 5.5 2.9 2 1 0 2 2 2 0 PcfK-like protein SR-25 PF10500.9 CDI86025.1 - 0.037 13.6 22.4 0.03 13.9 2.2 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Utp14 PF04615.13 CDI86025.1 - 2.1 6.8 34.2 3 6.3 34.2 1.2 1 0 0 1 1 1 0 Utp14 protein TRM13 PF05206.14 CDI86025.1 - 3.3 7.2 13.2 0.15 11.6 1.5 2.2 2 0 0 2 2 2 0 Methyltransferase TRM13 TMEM208_SND2 PF05620.11 CDI86025.1 - 3.4 7.4 19.9 1.2 8.9 4.8 3.5 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 U1snRNP70_N PF12220.8 CDI86025.1 - 7 7.4 20.1 2.3 8.9 6.5 2.5 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF2464 PF10240.9 CDI86025.1 - 10 5.6 11.8 3.4 7.1 0.7 2.2 2 0 0 2 2 2 0 Multivesicular body subunit 12 PAT1 PF09770.9 CDI86026.1 - 0.45 8.7 17.3 0.37 9.0 17.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Kei1 PF08552.11 CDI86026.1 - 0.61 9.9 7.8 0.045 13.6 2.4 1.7 1 1 1 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Lin-8 PF03353.15 CDI86026.1 - 0.92 9.0 10.5 0.88 9.1 10.5 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Secretin_N_2 PF07655.13 CDI86027.1 - 0.0039 17.7 15.8 0.0039 17.7 15.8 2.3 3 0 0 3 3 3 1 Secretin N-terminal domain SUIM_assoc PF16619.5 CDI86027.1 - 0.037 14.1 1.4 0.037 14.1 1.4 4.4 3 1 1 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 Chordopox_A20R PF05941.13 CDI86027.1 - 0.1 11.6 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Chordopoxvirus A20R protein AF-4 PF05110.13 CDI86027.1 - 0.12 10.4 35.4 0.012 13.8 18.5 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Lin-8 PF03353.15 CDI86027.1 - 0.51 9.8 25.0 0.24 10.9 5.5 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF4667 PF15700.5 CDI86027.1 - 1.9 8.5 24.5 0.17 11.9 11.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) DUF2722 PF10846.8 CDI86029.1 - 0.0014 17.6 20.9 0.0014 17.6 20.9 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF2722) FCP1_C PF09309.10 CDI86029.1 - 0.0036 17.2 6.4 0.0036 17.2 6.4 2.6 2 1 0 2 2 1 1 FCP1, C-terminal SfLAP PF11139.8 CDI86029.1 - 0.015 14.8 0.0 0.18 11.2 0.0 2.1 1 1 1 2 2 2 0 Sap, sulfolipid-1-addressing protein Fumble PF03630.14 CDI86029.1 - 0.024 13.8 10.9 0.35 10.0 2.2 2.2 2 0 0 2 2 2 0 Fumble Orf78 PF06024.12 CDI86029.1 - 0.027 14.8 6.9 0.027 14.8 6.9 3.0 3 0 0 3 3 3 0 Orf78 (ac78) SAM_decarbox PF01536.16 CDI86029.1 - 0.032 13.2 16.7 0.16 11.0 3.5 2.2 2 0 0 2 2 2 0 Adenosylmethionine decarboxylase Peptidase_S64 PF08192.11 CDI86029.1 - 0.24 9.9 27.2 0.33 9.4 27.2 1.2 1 0 0 1 1 1 0 Peptidase family S64 Gti1_Pac2 PF09729.9 CDI86029.1 - 0.4 10.8 26.9 2 8.4 10.2 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family FAM76 PF16046.5 CDI86029.1 - 0.41 9.9 31.1 0.29 10.4 10.3 2.2 2 0 0 2 2 2 0 FAM76 protein CLN3 PF02487.17 CDI86029.1 - 0.46 9.5 26.8 0.057 12.5 5.5 2.2 2 0 0 2 2 2 0 CLN3 protein DUF1943 PF09172.11 CDI86029.1 - 0.85 8.8 22.6 0.16 11.2 1.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) Scs3p PF10261.9 CDI86029.1 - 1.2 8.6 15.2 0.23 10.9 0.6 2.2 2 0 0 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM SLC12 PF03522.15 CDI86029.1 - 1.3 8.0 36.1 0.88 8.5 13.9 2.0 2 0 0 2 2 2 0 Solute carrier family 12 AAR2 PF05282.11 CDI86029.1 - 1.4 8.3 21.0 0.81 9.0 4.3 2.2 2 0 0 2 2 2 0 AAR2 protein Tim54 PF11711.8 CDI86029.1 - 1.5 7.5 28.7 1.5 7.6 10.5 2.3 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 MAT1 PF06391.13 CDI86029.1 - 1.6 8.5 50.8 0.35 10.7 17.8 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Ferlin_C PF16165.5 CDI86029.1 - 1.7 8.6 14.6 2 8.3 5.7 2.2 2 0 0 2 2 2 0 Ferlin C-terminus DUF4834 PF16118.5 CDI86029.1 - 1.9 9.5 42.6 2.5 9.1 14.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) TCP PF03634.13 CDI86029.1 - 2.2 8.8 32.7 0.15 12.6 5.6 2.7 3 0 0 3 3 3 0 TCP family transcription factor Zip PF02535.22 CDI86029.1 - 2.8 7.1 13.6 1.2 8.3 2.2 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter PPL5 PF18168.1 CDI86029.1 - 3 7.1 22.2 3.9 6.7 5.1 2.3 2 0 0 2 2 2 0 Prim-pol family 5 SpoVR PF04293.13 CDI86029.1 - 3 6.4 28.1 2 7.0 8.0 2.2 2 0 0 2 2 2 0 SpoVR like protein D123 PF07065.14 CDI86029.1 - 3.2 6.8 24.3 0.78 8.8 8.2 2.3 2 0 0 2 2 2 0 D123 Endostatin PF06482.11 CDI86029.1 - 3.4 7.0 29.9 0.81 9.1 7.6 2.3 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin TRAP_alpha PF03896.16 CDI86029.1 - 3.9 6.6 15.8 1.9 7.6 1.3 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Otopetrin PF03189.13 CDI86029.1 - 4.3 6.0 21.1 1.3 7.7 6.6 2.1 2 0 0 2 2 2 0 Otopetrin LicD PF04991.13 CDI86029.1 - 4.4 7.4 13.0 2 8.5 0.5 2.1 2 0 0 2 2 2 0 LicD family Tfb4 PF03850.14 CDI86029.1 - 5.1 6.5 28.0 0.2 11.1 8.5 2.2 2 0 0 2 2 2 0 Transcription factor Tfb4 CDC45 PF02724.14 CDI86029.1 - 5.1 5.3 24.0 2 6.6 6.2 2.1 2 0 0 2 2 2 0 CDC45-like protein FAM176 PF14851.6 CDI86029.1 - 5.9 6.6 23.8 0.82 9.3 3.5 2.6 3 0 0 3 3 2 0 FAM176 family OATP PF03137.20 CDI86029.1 - 5.9 5.1 23.9 0.18 10.0 4.9 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family CPSF73-100_C PF11718.8 CDI86029.1 - 6.3 6.3 21.4 1 8.9 6.1 2.2 2 0 0 2 2 2 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term AIF_C PF14721.6 CDI86029.1 - 7.7 6.9 27.3 0.72 10.2 4.8 3.0 3 0 0 3 3 3 0 Apoptosis-inducing factor, mitochondrion-associated, C-term SDF PF00375.18 CDI86029.1 - 8.2 5.3 13.3 7.5 5.5 1.9 2.2 2 0 0 2 2 2 0 Sodium:dicarboxylate symporter family PDDEXK_6 PF04720.12 CDI86029.1 - 8.5 6.3 25.9 4.4 7.2 9.3 2.2 2 0 0 2 2 2 0 PDDEXK-like family of unknown function Herpes_capsid PF06112.11 CDI86030.1 - 0.00077 19.6 6.9 0.00077 19.6 6.9 6.0 3 1 1 4 4 4 1 Gammaherpesvirus capsid protein eIF-3_zeta PF05091.12 CDI86030.1 - 0.0011 18.0 7.0 0.0011 18.0 7.0 5.7 3 2 2 5 5 5 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PID_2 PF14719.6 CDI86030.1 - 0.014 15.3 1.7 0.014 15.3 1.7 3.5 3 0 0 3 3 3 0 Phosphotyrosine interaction domain (PTB/PID) DUF4834 PF16118.5 CDI86030.1 - 0.02 15.9 9.9 0.02 15.9 9.9 10.8 3 2 1 4 4 4 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI86031.1 - 0.0023 17.6 5.6 0.0023 17.6 5.6 1.1 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI86031.1 - 0.0081 15.2 1.3 0.0081 15.2 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI86031.1 - 0.36 10.8 8.5 0.51 10.3 8.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Phostensin_N PF13916.6 CDI86031.1 - 1.8 9.0 5.9 4.4 7.7 5.9 1.6 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal DUF2116 PF09889.9 CDI86031.1 - 2.6 8.1 4.8 4.7 7.3 4.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) FTZ PF03867.14 CDI86031.1 - 9 5.8 12.6 12 5.3 12.6 1.4 1 1 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region Gly-zipper_OmpA PF13436.6 CDI86035.1 - 0.046 13.5 10.1 0.12 12.1 10.1 1.7 1 0 0 1 1 1 0 Glycine-zipper domain Bacteriocin_IIc PF10439.9 CDI86035.1 - 0.1 12.7 6.8 0.25 11.5 6.8 1.6 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Hamartin PF04388.12 CDI86035.1 - 0.15 10.7 42.6 0.19 10.3 42.6 1.2 1 0 0 1 1 1 0 Hamartin protein Gly-zipper_YMGG PF13441.6 CDI86035.1 - 2.2 8.1 7.7 5.5 6.8 7.7 1.6 1 0 0 1 1 1 0 YMGG-like Gly-zipper Vac7 PF12751.7 CDI86035.1 - 2.4 7.5 24.2 3.2 7.1 24.2 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 RskA PF10099.9 CDI86036.1 - 0.017 15.4 11.4 0.017 15.4 11.4 2.9 2 1 0 2 2 2 0 Anti-sigma-K factor rskA DUF4148 PF13663.6 CDI86036.1 - 0.11 12.7 0.5 0.11 12.7 0.5 5.0 5 0 0 5 5 5 0 Domain of unknown function (DUF4148) DUF572 PF04502.13 CDI86036.1 - 0.67 9.5 19.3 1 9.0 19.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF5134 PF17197.4 CDI86036.1 - 3.6 7.5 20.1 3.3 7.6 14.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5134) Presenilin PF01080.17 CDI86037.1 - 9.8e-05 21.3 18.0 0.00013 20.9 18.0 1.1 1 0 0 1 1 1 1 Presenilin Kei1 PF08552.11 CDI86037.1 - 0.0011 18.9 6.7 0.0011 18.9 6.7 1.6 2 0 0 2 2 2 1 Inositolphosphorylceramide synthase subunit Kei1 CDC45 PF02724.14 CDI86037.1 - 0.0015 16.9 12.4 0.0018 16.7 12.4 1.2 1 0 0 1 1 1 1 CDC45-like protein DUF4386 PF14329.6 CDI86037.1 - 0.012 15.5 2.0 0.02 14.7 2.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4386) ALMT PF11744.8 CDI86037.1 - 0.025 13.4 12.1 0.031 13.1 12.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SID-1_RNA_chan PF13965.6 CDI86037.1 - 0.031 12.7 7.3 0.036 12.5 7.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 CDI86037.1 - 0.036 13.0 8.9 0.039 12.9 8.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Serinc PF03348.15 CDI86037.1 - 0.045 12.7 11.0 0.049 12.6 11.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Neur_chan_memb PF02932.16 CDI86037.1 - 0.046 13.8 15.7 0.051 13.6 15.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PBP1_TM PF14812.6 CDI86037.1 - 0.087 13.2 5.8 0.032 14.6 2.5 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DAG_kinase_N PF14513.6 CDI86037.1 - 0.092 13.0 18.3 0.13 12.4 18.3 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus CbtA PF09490.10 CDI86037.1 - 0.12 12.2 0.6 0.18 11.6 0.6 1.4 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) Zip PF02535.22 CDI86037.1 - 0.17 11.1 10.0 0.19 10.9 10.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter AAR2 PF05282.11 CDI86037.1 - 0.18 11.1 12.6 0.22 10.9 12.6 1.1 1 0 0 1 1 1 0 AAR2 protein HCO3_cotransp PF00955.21 CDI86037.1 - 0.22 10.3 5.8 0.23 10.2 5.8 1.1 1 0 0 1 1 1 0 HCO3- transporter family SARAF PF06682.12 CDI86037.1 - 0.39 10.3 20.1 0.49 10.0 20.1 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2052 PF09747.9 CDI86037.1 - 0.51 10.4 28.0 0.71 10.0 28.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Ndc1_Nup PF09531.10 CDI86037.1 - 0.57 8.8 16.9 0.67 8.6 16.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Connexin PF00029.19 CDI86037.1 - 0.81 9.4 22.2 1.9 8.2 22.2 1.7 1 1 0 1 1 1 0 Connexin RBP_receptor PF14752.6 CDI86037.1 - 0.86 8.1 10.9 1.1 7.8 10.9 1.2 1 0 0 1 1 1 0 Retinol binding protein receptor LMBR1 PF04791.16 CDI86037.1 - 1 8.2 15.5 1.2 8.0 15.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Nha1_C PF08619.10 CDI86037.1 - 1.1 8.5 24.4 1.4 8.1 24.4 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus FAM91_C PF14648.6 CDI86037.1 - 1.3 7.8 12.1 1.6 7.5 12.1 1.2 1 0 0 1 1 1 0 FAM91 C-terminus DUF2347 PF09804.9 CDI86037.1 - 1.6 8.2 19.1 1.9 8.0 19.1 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) SLC12 PF03522.15 CDI86037.1 - 1.7 7.6 25.4 2.1 7.3 25.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4366 PF14283.6 CDI86037.1 - 1.8 8.6 13.7 1.8 8.6 10.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) DUF2828 PF11443.8 CDI86037.1 - 1.9 6.5 23.6 2.4 6.2 23.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) INSIG PF07281.12 CDI86037.1 - 2 8.0 14.8 80 2.8 14.3 2.1 1 1 0 1 1 1 0 Insulin-induced protein (INSIG) DUF1764 PF08576.10 CDI86037.1 - 2.1 9.3 20.5 0.52 11.2 15.1 2.0 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Peroxin-3 PF04882.12 CDI86037.1 - 2.2 7.1 23.7 2.6 6.9 23.7 1.1 1 0 0 1 1 1 0 Peroxin-3 BAF1_ABF1 PF04684.13 CDI86037.1 - 2.3 7.2 21.6 2.9 6.8 21.6 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Hid1 PF12722.7 CDI86037.1 - 2.6 6.1 21.1 2.9 5.9 21.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Cellulose_synt PF03552.14 CDI86037.1 - 2.8 6.3 6.4 2.7 6.4 6.4 1.1 1 0 0 1 1 1 0 Cellulose synthase Isy1 PF06246.12 CDI86037.1 - 3.6 7.1 28.4 4.4 6.8 28.4 1.1 1 0 0 1 1 1 0 Isy1-like splicing family DUF2126 PF09899.9 CDI86037.1 - 4 5.4 16.0 4.6 5.2 16.0 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) 5_nucleotid PF05761.14 CDI86037.1 - 4.1 6.2 15.4 6.3 5.6 15.4 1.3 1 0 0 1 1 1 0 5' nucleotidase family DREPP PF05558.12 CDI86037.1 - 4.2 7.2 8.0 5.9 6.7 8.0 1.2 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide O-antigen_lig PF13425.6 CDI86037.1 - 4.4 6.0 13.8 5.3 5.7 13.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF3604 PF12228.8 CDI86037.1 - 4.8 5.5 15.3 6 5.2 15.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3604) SRAP PF02586.14 CDI86037.1 - 5.6 6.4 14.5 0.15 11.6 8.7 1.4 2 0 0 2 2 1 0 SOS response associated peptidase (SRAP) TraV PF09676.10 CDI86037.1 - 6.3 7.8 19.9 0.24 12.4 12.7 1.9 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) Herpes_MCP PF03122.14 CDI86037.1 - 7.2 3.9 14.3 8.2 3.7 14.3 1.0 1 0 0 1 1 1 0 Herpes virus major capsid protein ABC2_membrane PF01061.24 CDI86038.1 - 2.8e-13 49.8 10.8 4.2e-13 49.2 10.8 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 CDI86038.1 - 4.1e-06 27.3 0.0 6.9e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 CDI86038.1 - 4e-05 22.9 9.0 5.6e-05 22.4 9.0 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein PDR_CDR PF06422.12 CDI86038.1 - 0.0036 17.2 0.0 0.0086 16.0 0.0 1.6 1 0 0 1 1 1 1 CDR ABC transporter ABC2_membrane_2 PF12679.7 CDI86038.1 - 0.14 11.4 4.4 0.2 10.9 4.4 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein WW PF00397.26 CDI86039.1 - 8e-09 35.4 0.5 1.8e-08 34.3 0.5 1.6 1 0 0 1 1 1 1 WW domain DegT_DnrJ_EryC1 PF01041.17 CDI86040.1 - 3.8e-15 56.1 0.0 3.9e-13 49.4 0.0 2.4 2 1 1 3 3 3 2 DegT/DnrJ/EryC1/StrS aminotransferase family DUF3054 PF11255.8 CDI86040.1 - 0.15 12.6 0.0 0.4 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3054) AAA_6 PF12774.7 CDI86041.1 - 1e-137 458.5 0.0 2.9e-137 457.0 0.0 1.8 2 0 0 2 2 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDI86041.1 - 6.1e-97 325.2 0.3 6.1e-97 325.2 0.3 3.9 4 0 0 4 4 3 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 CDI86041.1 - 9.6e-45 153.1 0.1 2.2e-42 145.4 0.0 2.5 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain MT PF12777.7 CDI86041.1 - 5.2e-41 140.8 6.1 5.2e-41 140.8 6.1 1.8 2 0 0 2 2 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 CDI86041.1 - 2.2e-38 131.0 0.2 3.1e-37 127.3 0.0 3.2 3 0 0 3 3 1 1 Dynein heavy chain region D6 P-loop domain AAA_7 PF12775.7 CDI86041.1 - 9.1e-37 126.3 0.0 1.6e-31 109.2 0.0 3.4 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 CDI86041.1 - 1.2e-36 126.0 0.0 2.8e-36 124.8 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_9 PF12781.7 CDI86041.1 - 7.6e-21 74.3 4.3 4.4e-17 62.0 0.0 4.6 3 1 1 4 4 4 1 ATP-binding dynein motor region AAA_5 PF07728.14 CDI86041.1 - 3.1e-18 66.1 0.0 5.4e-06 26.5 0.0 5.6 3 2 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_8 PF12780.7 CDI86041.1 - 1.2e-16 60.8 0.2 1.2e-15 57.5 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_18 PF13238.6 CDI86041.1 - 6.4e-12 46.1 0.0 0.0018 18.8 0.0 4.2 4 0 0 4 4 3 2 AAA domain AAA_16 PF13191.6 CDI86041.1 - 2.6e-11 44.2 1.3 0.0028 18.1 0.0 6.0 5 0 0 5 5 4 2 AAA ATPase domain Dynein_AAA_lid PF17852.1 CDI86041.1 - 3.2e-11 43.4 0.9 2.8e-10 40.4 0.0 2.9 3 0 0 3 3 2 1 Dynein heavy chain AAA lid domain AAA PF00004.29 CDI86041.1 - 5.8e-09 36.5 0.2 0.0047 17.3 0.0 4.5 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDI86041.1 - 3.7e-08 33.7 0.2 0.14 12.4 0.0 4.9 4 0 0 4 4 4 2 AAA domain AAA_33 PF13671.6 CDI86041.1 - 9.5e-06 25.8 0.0 0.81 9.8 0.0 3.9 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 CDI86041.1 - 2e-05 24.6 2.4 1.2 9.1 0.0 5.4 5 1 0 5 5 4 2 NACHT domain AAA_28 PF13521.6 CDI86041.1 - 2.7e-05 24.5 0.3 1.1 9.5 0.0 4.5 4 0 0 4 4 4 2 AAA domain AAA_29 PF13555.6 CDI86041.1 - 5.2e-05 22.9 0.5 0.062 13.0 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 CDI86041.1 - 8.8e-05 22.3 0.6 3.3 7.4 0.0 3.6 3 0 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 CDI86041.1 - 0.00024 20.9 0.4 0.96 9.1 0.1 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 CDI86041.1 - 0.00041 20.7 0.0 7 7.1 0.0 3.7 3 0 0 3 3 3 0 RNA helicase HrpB7 PF09486.10 CDI86041.1 - 0.00063 20.2 2.3 0.00063 20.2 2.3 4.0 4 0 0 4 4 2 1 Bacterial type III secretion protein (HrpB7) MMR_HSR1 PF01926.23 CDI86041.1 - 0.0017 18.4 0.0 0.29 11.2 0.1 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Mg_chelatase PF01078.21 CDI86041.1 - 0.0036 16.7 1.9 0.22 10.9 0.0 2.8 3 0 0 3 3 2 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 CDI86041.1 - 0.0037 17.2 0.1 9.7 6.2 0.0 3.6 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 CDI86041.1 - 0.0052 16.4 4.0 0.74 9.4 0.1 3.8 3 0 0 3 3 3 1 AAA domain DUF2075 PF09848.9 CDI86041.1 - 0.016 14.4 0.0 6.9 5.8 0.1 2.9 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) Ploopntkinase3 PF18751.1 CDI86041.1 - 0.018 15.0 0.0 0.33 10.8 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_24 PF13479.6 CDI86041.1 - 0.037 13.7 0.0 25 4.5 0.0 3.6 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 CDI86041.1 - 0.038 13.9 0.7 7.4 6.5 0.1 3.6 3 0 0 3 3 3 0 NTPase ABC_tran PF00005.27 CDI86041.1 - 0.038 14.5 0.0 3 8.3 0.0 3.4 2 0 0 2 2 2 0 ABC transporter T2SSE PF00437.20 CDI86041.1 - 0.045 12.8 0.0 0.85 8.6 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_19 PF13245.6 CDI86041.1 - 0.086 13.2 8.1 3.2 8.1 0.0 4.5 4 0 0 4 4 4 0 AAA domain Zeta_toxin PF06414.12 CDI86041.1 - 0.092 12.0 2.5 2 7.6 0.1 3.3 3 0 0 3 3 3 0 Zeta toxin TIP49 PF06068.13 CDI86041.1 - 0.1 11.8 0.8 2.1 7.5 0.0 2.7 3 0 0 3 3 2 0 TIP49 P-loop domain FliJ PF02050.16 CDI86041.1 - 0.2 11.9 11.3 0.094 12.9 0.8 4.1 3 0 0 3 3 2 0 Flagellar FliJ protein cobW PF02492.19 CDI86041.1 - 0.22 11.1 0.8 23 4.5 0.0 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF948 PF06103.11 CDI86041.1 - 0.5 10.7 5.6 30 4.9 0.2 4.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Sec8_exocyst PF04048.14 CDI86041.1 - 0.7 9.8 10.8 0.44 10.4 0.4 5.0 4 1 1 5 5 4 0 Sec8 exocyst complex component specific domain Rad17 PF03215.15 CDI86041.1 - 1.1 9.2 3.7 15 5.4 0.0 3.5 4 0 0 4 4 2 0 Rad17 P-loop domain DUF1664 PF07889.12 CDI86041.1 - 1.7 8.7 5.2 24 5.0 0.4 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FtsK_SpoIIIE PF01580.18 CDI86041.1 - 2.2 7.5 6.9 0.55 9.5 0.0 3.2 4 0 0 4 4 4 0 FtsK/SpoIIIE family AcylCoA_dehyd_C PF12186.8 CDI86041.1 - 5.8 7.1 9.2 2.3 8.4 0.4 3.4 3 0 0 3 3 2 0 Acyl-CoA dehydrogenase C terminal CorA PF01544.18 CDI86041.1 - 8.9 5.5 11.1 1 8.6 0.3 3.8 3 1 1 4 4 4 0 CorA-like Mg2+ transporter protein Exonuc_VII_L PF02601.15 CDI86042.1 - 1.3 8.5 8.4 2 7.9 8.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit MeaB PF03308.16 CDI86042.1 - 1.4 7.8 5.3 2 7.3 5.3 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF883 PF05957.13 CDI86042.1 - 2.7 8.7 7.5 10 6.8 1.0 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF2362 PF10154.9 CDI86042.1 - 3.7 6.4 12.9 5.2 5.9 12.9 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) Retrotrans_gag PF03732.17 CDI86042.1 - 5.7 7.3 11.6 20 5.6 11.1 2.2 2 1 0 2 2 2 0 Retrotransposon gag protein Peptidase_A17 PF05380.13 CDI86042.1 - 5.7 6.9 9.7 1.7 8.7 2.0 2.9 2 1 1 3 3 3 0 Pao retrotransposon peptidase UCH PF00443.29 CDI86043.1 - 2.3e-45 155.1 0.0 4.9e-45 154.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 CDI86043.1 - 2.3e-12 47.1 0.1 7.9e-11 42.1 0.0 3.0 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 CDI86043.1 - 3.4e-10 39.6 1.1 3.3e-06 26.9 0.1 3.7 3 0 0 3 3 3 2 UBA/TS-N domain UCH_1 PF13423.6 CDI86043.1 - 1.5e-09 38.0 0.2 0.00052 19.7 0.1 3.3 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 CDI86043.1 - 0.023 14.4 0.0 0.059 13.1 0.0 1.7 1 0 0 1 1 1 0 Variant UBP zinc finger Dis3l2_C_term PF17877.1 CDI86043.1 - 0.064 13.6 0.1 0.21 11.9 0.1 1.9 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal SRP14 PF02290.15 CDI86044.1 - 1e-18 67.4 1.1 1.9e-17 63.4 0.0 2.2 1 1 1 2 2 2 1 Signal recognition particle 14kD protein DUF1082 PF06449.11 CDI86044.1 - 0.24 11.2 0.8 1.5 8.7 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial domain of unknown function (DUF1082) EIIBC-GUT_N PF03612.14 CDI86044.1 - 0.49 10.1 5.0 0.7 9.6 5.0 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 CDI86044.1 - 2.9 6.6 4.4 2.9 6.5 4.4 1.1 1 0 0 1 1 1 0 Presenilin Eapp_C PF10238.9 CDI86044.1 - 4.8 7.3 9.6 6.5 6.8 9.6 1.5 1 1 0 1 1 1 0 E2F-associated phosphoprotein RskA PF10099.9 CDI86045.1 - 0.0003 21.1 19.9 0.0063 16.8 14.7 5.4 1 1 1 3 3 3 2 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI86045.1 - 0.0025 16.8 11.0 0.0025 16.8 11.0 2.4 2 0 0 2 2 2 1 Transcriptional activator LAG-3 FliD_N PF02465.18 CDI86045.1 - 0.015 16.0 12.2 0.015 16.0 12.2 5.7 4 1 0 4 4 4 0 Flagellar hook-associated protein 2 N-terminus Miga PF10265.9 CDI86045.1 - 0.78 8.6 9.8 1.4 7.8 9.8 1.7 1 0 0 1 1 1 0 Mitoguardin VirC2 PF07181.11 CDI86046.1 - 0.0024 17.4 1.9 0.0028 17.2 1.9 1.1 1 0 0 1 1 1 1 VirC2 protein Suf PF05843.14 CDI86046.1 - 0.007 16.4 13.2 0.0076 16.3 13.2 1.0 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Spt20 PF12090.8 CDI86046.1 - 0.0093 15.6 29.0 0.0099 15.5 29.0 1.1 1 0 0 1 1 1 1 Spt20 family tRNA_synt_1c_R2 PF04557.15 CDI86046.1 - 0.046 14.6 5.1 0.052 14.5 5.1 1.1 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DDE_Tnp_1 PF01609.21 CDI86046.1 - 0.065 12.9 1.7 0.072 12.7 1.7 1.0 1 0 0 1 1 1 0 Transposase DDE domain CPSF100_C PF13299.6 CDI86046.1 - 0.075 13.2 6.0 0.076 13.2 6.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Band_3_cyto PF07565.13 CDI86046.1 - 0.078 12.8 7.5 0.08 12.7 7.5 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4770 PF15994.5 CDI86046.1 - 0.1 12.8 11.0 0.11 12.8 11.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) RPA43_OB PF17875.1 CDI86046.1 - 0.12 13.0 5.2 0.13 12.9 5.2 1.1 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Peptidase_S49_N PF08496.10 CDI86046.1 - 0.14 12.2 5.9 0.14 12.2 5.9 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal eIF-3_zeta PF05091.12 CDI86046.1 - 0.17 10.8 10.0 0.17 10.8 10.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2126 PF09899.9 CDI86046.1 - 0.22 9.5 4.7 0.22 9.5 4.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF2722 PF10846.8 CDI86046.1 - 0.24 10.3 27.3 0.26 10.2 27.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI86046.1 - 0.41 10.6 28.2 0.43 10.5 28.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CDI86046.1 - 0.45 11.2 18.4 0.53 10.9 18.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region GNAT_acetyltr_2 PF13718.6 CDI86046.1 - 0.48 9.8 7.5 0.54 9.6 7.5 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DUF702 PF05142.12 CDI86046.1 - 0.5 10.8 8.3 0.54 10.7 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) EIIBC-GUT_N PF03612.14 CDI86046.1 - 0.51 10.1 8.5 0.53 10.0 8.5 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus SpoIIP PF07454.11 CDI86046.1 - 0.55 9.6 11.0 0.55 9.6 11.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.8 CDI86046.1 - 0.58 8.9 8.7 0.59 8.9 8.7 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Sec62 PF03839.16 CDI86046.1 - 0.62 9.5 5.2 0.6 9.6 5.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 NPR1_interact PF15699.5 CDI86046.1 - 0.62 10.7 13.0 0.81 10.3 13.0 1.2 1 0 0 1 1 1 0 NPR1 interacting Med15 PF09606.10 CDI86046.1 - 0.76 8.4 25.0 0.8 8.3 25.0 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Gti1_Pac2 PF09729.9 CDI86046.1 - 0.78 9.8 7.3 0.81 9.8 7.3 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family TERB2 PF15101.6 CDI86046.1 - 0.85 9.6 16.2 0.91 9.5 16.2 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4834 PF16118.5 CDI86046.1 - 0.87 10.6 10.9 1 10.4 10.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 CDI86046.1 - 0.88 9.2 7.7 1 9.0 7.7 1.1 1 0 0 1 1 1 0 FAM176 family RR_TM4-6 PF06459.12 CDI86046.1 - 0.88 9.3 11.1 0.89 9.3 11.1 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 CDI86046.1 - 1.2 9.3 9.0 1.2 9.3 9.0 1.1 1 0 0 1 1 1 0 DDHD domain Roughex PF06020.11 CDI86046.1 - 1.2 8.2 16.7 1.3 8.0 16.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein CobT PF06213.12 CDI86046.1 - 1.2 8.5 18.0 1.3 8.4 18.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Neur_chan_memb PF02932.16 CDI86046.1 - 1.2 9.1 7.1 1.3 9.0 7.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF775 PF05603.12 CDI86046.1 - 1.2 8.6 12.3 1.3 8.5 12.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) EPL1 PF10513.9 CDI86046.1 - 1.3 9.4 13.2 1.4 9.3 13.2 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like Connexin PF00029.19 CDI86046.1 - 1.3 8.7 7.0 1.4 8.6 7.0 1.1 1 0 0 1 1 1 0 Connexin MMR1 PF08505.10 CDI86046.1 - 1.3 9.2 17.2 1.6 9.0 17.2 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Presenilin PF01080.17 CDI86046.1 - 1.6 7.4 12.3 1.6 7.4 12.3 1.0 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 CDI86046.1 - 2 7.2 7.9 2 7.2 7.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter PepSY_TM PF03929.16 CDI86046.1 - 2.1 7.9 6.5 2 8.0 6.5 1.0 1 0 0 1 1 1 0 PepSY-associated TM region Folate_carrier PF01770.18 CDI86046.1 - 2.2 6.9 5.9 2.2 6.9 5.9 1.0 1 0 0 1 1 1 0 Reduced folate carrier CLN3 PF02487.17 CDI86046.1 - 2.3 7.2 7.9 2.3 7.2 7.9 1.0 1 0 0 1 1 1 0 CLN3 protein G6B PF15096.6 CDI86046.1 - 2.3 7.9 4.2 2.7 7.8 4.2 1.1 1 0 0 1 1 1 0 G6B family RNA_pol_Rbc25 PF08292.12 CDI86046.1 - 2.3 8.4 10.0 3.1 8.1 10.0 1.2 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 DUF1682 PF07946.14 CDI86046.1 - 2.4 7.3 9.9 2.5 7.3 9.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) TMEM51 PF15345.6 CDI86046.1 - 2.4 7.9 12.2 2.6 7.8 12.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 REC114-like PF15165.6 CDI86046.1 - 2.6 7.8 14.7 3 7.6 14.7 1.0 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like DUF3276 PF11680.8 CDI86046.1 - 2.9 8.0 9.5 3.9 7.6 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) USP8_interact PF08941.10 CDI86046.1 - 3.1 7.6 11.6 3.7 7.3 11.6 1.1 1 0 0 1 1 1 0 USP8 interacting V_ATPase_I PF01496.19 CDI86046.1 - 3.2 5.6 10.2 3.1 5.6 10.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Paf1 PF03985.13 CDI86046.1 - 3.4 6.6 15.4 3.7 6.4 15.4 1.0 1 0 0 1 1 1 0 Paf1 AIF_C PF14721.6 CDI86046.1 - 3.4 8.0 8.2 3.9 7.8 8.2 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Ndc1_Nup PF09531.10 CDI86046.1 - 3.6 6.2 12.3 3.7 6.1 12.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAM60A PF15396.6 CDI86046.1 - 3.6 7.5 7.8 3.8 7.5 7.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A OATP PF03137.20 CDI86046.1 - 3.7 5.7 7.2 3.8 5.7 7.2 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family ATP-synt_E PF05680.12 CDI86046.1 - 4.1 7.8 11.8 5.1 7.5 11.8 1.1 1 0 0 1 1 1 0 ATP synthase E chain Membralin PF09746.9 CDI86046.1 - 4.2 6.3 6.8 4.6 6.2 6.8 1.0 1 0 0 1 1 1 0 Tumour-associated protein EMC3_TMCO1 PF01956.16 CDI86046.1 - 4.8 6.9 7.4 4.7 6.9 7.4 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Orf78 PF06024.12 CDI86046.1 - 4.8 7.5 7.6 6.1 7.2 7.6 1.2 1 0 0 1 1 1 0 Orf78 (ac78) PAT1 PF09770.9 CDI86046.1 - 4.9 5.3 19.4 5.1 5.2 19.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Kei1 PF08552.11 CDI86046.1 - 5.2 6.9 6.9 5.9 6.7 6.9 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF3464 PF11947.8 CDI86046.1 - 5.4 6.8 11.4 6 6.6 11.4 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Ufd2P_core PF10408.9 CDI86046.1 - 5.4 5.5 15.0 5.5 5.5 15.0 1.0 1 0 0 1 1 1 0 Ubiquitin elongating factor core DUF1800 PF08811.11 CDI86046.1 - 6 5.8 13.8 7.3 5.5 13.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) VIT1 PF01988.19 CDI86046.1 - 6.2 6.6 9.2 7.6 6.3 9.2 1.1 1 0 0 1 1 1 0 VIT family DUF4175 PF13779.6 CDI86046.1 - 7.8 4.3 27.1 8.1 4.2 27.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4407 PF14362.6 CDI86046.1 - 8 5.7 14.0 8.6 5.6 14.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3043 PF11241.8 CDI86046.1 - 8.1 6.4 7.0 9.2 6.3 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) FHIPEP PF00771.20 CDI86046.1 - 8.3 4.7 8.2 8.2 4.8 8.2 1.1 1 0 0 1 1 1 0 FHIPEP family UPF0560 PF10577.9 CDI86046.1 - 8.7 4.7 18.3 9.2 4.6 18.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Ctr PF04145.15 CDI86046.1 - 9.7 6.8 6.8 11 6.7 6.8 1.1 1 0 0 1 1 1 0 Ctr copper transporter family CSG2 PF16965.5 CDI86046.1 - 9.8 5.0 7.2 9.8 5.0 7.2 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator RIFIN PF02009.16 CDI86047.1 - 0.9 9.4 18.9 1.1 9.1 18.9 1.0 1 0 0 1 1 1 0 Rifin Raftlin PF15250.6 CDI86047.1 - 3.4 6.3 21.2 3.8 6.1 21.2 1.1 1 0 0 1 1 1 0 Raftlin SLC12 PF03522.15 CDI86047.1 - 7.6 5.4 22.2 10 5.0 22.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 CH_2 PF06294.11 CDI86048.1 - 9e-18 64.2 0.2 2.3e-17 62.9 0.0 1.7 2 0 0 2 2 2 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 CDI86048.1 - 0.00057 19.7 0.0 0.00084 19.1 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain RLL PF10036.9 CDI86048.1 - 0.025 14.5 4.2 0.028 14.3 4.2 1.1 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein Mt_ATP-synt_D PF05873.12 CDI86048.1 - 0.057 13.3 2.0 0.16 11.9 1.0 1.8 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) tRNA-synt_2b PF00587.25 CDI86048.1 - 0.091 12.7 0.0 0.11 12.5 0.0 1.2 1 1 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) MYO10_CC PF16735.5 CDI86048.1 - 0.13 12.3 15.0 1.7 8.8 0.5 2.7 2 1 1 3 3 3 0 Unconventional myosin-X coiled coil domain DUF3972 PF13118.6 CDI86048.1 - 0.39 11.2 6.4 3 8.3 6.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3972) GTA_holin_3TM PF11351.8 CDI86048.1 - 0.43 11.1 4.7 0.73 10.4 4.7 1.4 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release FliN_N PF16973.5 CDI86048.1 - 2.2 8.2 8.5 5.4 6.9 2.2 2.7 2 1 1 3 3 3 0 Flagellar motor switch protein FliN N-terminal SR-25 PF10500.9 CDI86049.1 - 0.00048 19.8 11.8 0.00048 19.8 11.8 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein M_domain PF12938.7 CDI86049.1 - 0.016 15.1 12.5 0.017 14.9 12.5 1.1 1 0 0 1 1 1 0 M domain of GW182 IMUP PF15761.5 CDI86049.1 - 0.024 15.3 9.9 0.027 15.2 9.9 1.1 1 0 0 1 1 1 0 Immortalisation up-regulated protein Spt20 PF12090.8 CDI86049.1 - 0.12 12.0 7.9 0.12 11.9 7.9 1.0 1 0 0 1 1 1 0 Spt20 family Conotoxin PF02950.17 CDI86049.1 - 0.14 13.2 0.9 0.17 13.0 0.9 1.1 1 0 0 1 1 1 0 Conotoxin DUF1635 PF07795.11 CDI86049.1 - 0.17 11.7 8.8 0.19 11.5 8.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Lin-8 PF03353.15 CDI86049.1 - 0.43 10.1 6.8 0.44 10.0 6.8 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Roughex PF06020.11 CDI86049.1 - 0.91 8.5 5.6 1 8.4 5.6 1.0 1 0 0 1 1 1 0 Drosophila roughex protein RAP1 PF07218.11 CDI86049.1 - 1 7.6 5.4 0.94 7.7 5.4 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Ctr PF04145.15 CDI86049.1 - 1 10.0 3.2 1.2 9.7 3.2 1.0 1 0 0 1 1 1 0 Ctr copper transporter family Presenilin PF01080.17 CDI86049.1 - 1.5 7.5 4.4 1.7 7.4 4.4 1.0 1 0 0 1 1 1 0 Presenilin DUF2967 PF11179.8 CDI86049.1 - 3.2 5.7 16.6 3.2 5.8 16.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Zip PF02535.22 CDI86050.1 - 0.00035 19.9 12.7 0.0016 17.7 5.8 2.2 2 0 0 2 2 2 2 ZIP Zinc transporter DUF4834 PF16118.5 CDI86050.1 - 0.00043 21.2 10.8 0.00043 21.2 10.8 3.4 2 1 1 3 3 2 1 Domain of unknown function (DUF4834) DUF2722 PF10846.8 CDI86050.1 - 0.0018 17.3 14.0 0.0018 17.3 14.0 3.4 2 1 1 3 3 1 1 Protein of unknown function (DUF2722) DUF3295 PF11702.8 CDI86050.1 - 0.0061 16.0 12.8 0.0061 16.0 12.8 2.5 1 1 1 3 3 1 1 Protein of unknown function (DUF3295) Spt20 PF12090.8 CDI86050.1 - 0.013 15.1 25.8 0.013 15.1 25.8 3.2 2 1 1 3 3 1 0 Spt20 family SLC12 PF03522.15 CDI86050.1 - 0.017 14.2 38.6 0.14 11.2 26.0 2.1 2 0 0 2 2 2 0 Solute carrier family 12 MAP17 PF15807.5 CDI86050.1 - 0.02 15.1 6.8 0.02 15.1 6.8 3.3 2 1 1 3 3 3 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Sporozoite_P67 PF05642.11 CDI86050.1 - 0.033 12.3 11.9 0.051 11.7 11.9 1.3 1 1 0 1 1 1 0 Sporozoite P67 surface antigen Lin-8 PF03353.15 CDI86050.1 - 0.13 11.8 52.9 0.27 10.8 35.3 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF3807 PF12720.7 CDI86050.1 - 0.51 10.6 56.7 0.12 12.7 8.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) FAM60A PF15396.6 CDI86050.1 - 2.7 8.0 34.7 2.5 8.1 4.8 2.3 2 0 0 2 2 2 0 Protein Family FAM60A PA26 PF04636.13 CDI86050.1 - 3.5 6.4 33.5 0.92 8.4 20.7 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Cadherin_C_2 PF16492.5 CDI86050.1 - 5.6 7.8 12.3 0.9 10.3 3.8 2.9 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal Dynamin_N PF00350.23 CDI86051.1 - 3.7e-06 27.1 0.0 4.8e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 CDI86051.1 - 0.0065 16.7 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 CDI86051.1 - 0.025 14.1 0.0 4.3 6.8 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain cobW PF02492.19 CDI86051.1 - 0.13 11.8 0.0 7.3 6.1 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 CDI86051.1 - 0.14 12.4 0.0 0.4 10.9 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 CDI86051.1 - 0.14 11.4 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Septin SR-25 PF10500.9 CDI86053.1 - 2.7e-06 27.2 53.9 0.00038 20.1 24.3 2.1 1 1 0 2 2 2 2 Nuclear RNA-splicing-associated protein FA_desaturase PF00487.24 CDI86053.1 - 0.0024 17.7 0.0 0.0036 17.2 0.0 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF4813 PF16072.5 CDI86053.1 - 2.2 7.9 17.2 2.8 7.5 17.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Utp14 PF04615.13 CDI86053.1 - 6.8 5.1 40.7 7.7 5.0 40.7 1.0 1 0 0 1 1 1 0 Utp14 protein SR-25 PF10500.9 CDI86054.1 - 0.0051 16.5 18.6 0.0059 16.3 18.6 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein SID-1_RNA_chan PF13965.6 CDI86054.1 - 0.19 10.1 5.4 0.21 9.9 5.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 eIF-3_zeta PF05091.12 CDI86054.1 - 0.24 10.3 20.5 0.25 10.3 20.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SprA-related PF12118.8 CDI86054.1 - 0.44 9.6 40.2 0.47 9.5 40.2 1.0 1 0 0 1 1 1 0 SprA-related family Hamartin PF04388.12 CDI86054.1 - 0.65 8.6 22.8 0.71 8.5 22.8 1.0 1 0 0 1 1 1 0 Hamartin protein TFIIA PF03153.13 CDI86054.1 - 0.67 9.9 50.7 0.76 9.7 50.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zip PF02535.22 CDI86054.1 - 0.72 9.0 12.2 0.77 8.9 12.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CSG2 PF16965.5 CDI86054.1 - 0.93 8.4 8.2 0.97 8.3 8.2 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator FAM60A PF15396.6 CDI86054.1 - 1.1 9.2 17.4 1.2 9.1 17.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Velvet PF11754.8 CDI86054.1 - 1.3 8.9 20.8 1.5 8.7 20.8 1.3 1 0 0 1 1 1 0 Velvet factor Serinc PF03348.15 CDI86054.1 - 1.3 7.8 10.7 1.6 7.6 10.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) SMYLE_N PF18615.1 CDI86054.1 - 1.6 8.2 19.8 1.9 8.0 19.8 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain 2OG-FeII_Oxy_5 PF13759.6 CDI86054.1 - 2.1 8.8 9.5 4 7.9 9.5 1.4 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Neur_chan_memb PF02932.16 CDI86054.1 - 2.2 8.3 15.5 2.4 8.2 15.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spore_coat_CotO PF14153.6 CDI86054.1 - 2.3 8.1 27.1 2.8 7.8 27.1 1.3 1 0 0 1 1 1 0 Spore coat protein CotO VIR_N PF15912.5 CDI86054.1 - 2.5 7.6 11.0 2.9 7.4 11.0 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Connexin PF00029.19 CDI86054.1 - 3 7.5 11.9 3.8 7.2 11.9 1.3 1 0 0 1 1 1 0 Connexin Activator_LAG-3 PF11498.8 CDI86054.1 - 3.5 6.5 44.9 3.9 6.3 44.9 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SLC12 PF03522.15 CDI86054.1 - 3.7 6.5 19.0 3.8 6.4 19.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Suf PF05843.14 CDI86054.1 - 3.8 7.4 28.3 4.6 7.1 28.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF5427 PF10310.9 CDI86054.1 - 4.3 6.2 25.7 5.3 5.9 25.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) RR_TM4-6 PF06459.12 CDI86054.1 - 4.6 7.0 22.9 4.9 6.9 22.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2126 PF09899.9 CDI86054.1 - 4.6 5.2 12.6 4.6 5.2 12.6 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF2992 PF11208.8 CDI86054.1 - 5 7.4 26.1 6.3 7.1 26.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Peptidase_S15 PF02129.18 CDI86054.1 - 5.2 6.6 17.1 6.8 6.2 17.1 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Endostatin PF06482.11 CDI86054.1 - 5.5 6.4 20.5 5.8 6.3 20.5 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin V_ATPase_I PF01496.19 CDI86054.1 - 6.2 4.6 19.7 6.6 4.5 19.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MMR1 PF08505.10 CDI86054.1 - 8.8 6.5 25.9 11 6.2 25.9 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein IHABP4_N PF16174.5 CDI86054.1 - 9 6.9 27.7 14 6.3 27.7 1.3 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal MAJIN PF15077.6 CDI86054.1 - 9.8 5.9 16.9 10 5.8 16.9 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF3464 PF11947.8 CDI86055.1 - 2.2e-05 24.2 13.5 0.0016 18.2 6.5 3.7 2 1 2 4 4 4 2 Photosynthesis affected mutant 68 Tankyrase_bdg_C PF15327.6 CDI86055.1 - 0.057 13.9 12.3 0.29 11.6 3.8 3.2 3 0 0 3 3 3 0 Tankyrase binding protein C terminal domain CbiJ PF02571.14 CDI86055.1 - 0.061 12.8 9.3 2 7.8 2.7 2.4 1 1 1 2 2 2 0 Precorrin-6x reductase CbiJ/CobK DUF4598 PF15370.6 CDI86055.1 - 0.18 12.3 16.5 2.7 8.5 3.5 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4598) Peroxin-13_N PF04088.13 CDI86055.1 - 0.18 12.1 14.7 1.3 9.3 2.4 3.5 4 0 0 4 4 4 0 Peroxin 13, N-terminal region Folate_carrier PF01770.18 CDI86055.1 - 0.62 8.7 14.0 1 8.0 3.0 2.9 3 0 0 3 3 3 0 Reduced folate carrier KAP_NTPase PF07693.14 CDI86055.1 - 2 7.5 7.7 0.24 10.6 3.0 1.7 2 0 0 2 2 2 0 KAP family P-loop domain FAM176 PF14851.6 CDI86055.1 - 3.6 7.2 23.6 0.086 12.5 4.1 3.7 3 1 1 4 4 4 0 FAM176 family Ribosomal_60s PF00428.19 CDI86055.1 - 4.6 7.9 49.2 4 8.1 2.2 4.2 4 0 0 4 4 4 0 60s Acidic ribosomal protein G0-G1_switch_2 PF15103.6 CDI86055.1 - 6.7 7.2 27.0 2.5 8.5 0.5 3.7 4 0 0 4 4 4 0 G0/G1 switch protein 2 TIR-like PF10137.9 CDI86055.1 - 9.1 6.3 11.8 0.56 10.2 0.9 3.0 2 1 1 3 3 3 0 Predicted nucleotide-binding protein containing TIR-like domain DUF2339 PF10101.9 CDI86057.1 - 0.071 11.7 19.1 0.036 12.6 1.6 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2339) Coilin_N PF15862.5 CDI86057.1 - 0.92 9.3 0.0 0.92 9.3 0.0 12.2 7 3 4 11 11 11 0 Coilin N-terminus AF-4 PF05110.13 CDI86058.1 - 0.85 7.6 45.2 1 7.4 45.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Macoilin PF09726.9 CDI86058.1 - 1.9 7.0 29.9 2.5 6.5 29.9 1.1 1 0 0 1 1 1 0 Macoilin family DUF572 PF04502.13 CDI86058.1 - 2 8.0 36.9 3.1 7.4 36.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Vac7 PF12751.7 CDI86058.1 - 2.3 7.5 20.4 3.5 7.0 20.4 1.2 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 Apt1 PF10351.9 CDI86058.1 - 3.2 6.5 26.1 4.3 6.1 26.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain CDC45 PF02724.14 CDI86058.1 - 3.6 5.7 37.5 4.8 5.3 37.5 1.1 1 0 0 1 1 1 0 CDC45-like protein AbLIM_anchor PF16182.5 CDI86058.1 - 3.8 7.2 30.7 4.7 6.9 30.7 1.1 1 0 0 1 1 1 0 Putative adherens-junction anchoring region of AbLIM DUF4045 PF13254.6 CDI86058.1 - 5.6 6.5 39.3 7.1 6.2 39.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SAPS PF04499.15 CDI86058.1 - 8.1 5.1 31.5 11 4.7 31.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein GREB1 PF15782.5 CDI86058.1 - 9.9 3.1 41.2 11 3.0 41.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIA PF03153.13 CDI86059.1 - 0.21 11.6 8.0 0.23 11.4 8.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI86060.1 - 0.0019 17.8 12.3 0.0022 17.7 12.3 1.1 1 0 0 1 1 1 1 Spt20 family DUF4834 PF16118.5 CDI86060.1 - 0.014 16.3 1.4 0.018 16.0 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2722 PF10846.8 CDI86060.1 - 0.029 13.3 9.7 0.033 13.1 9.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI86060.1 - 0.049 13.6 13.8 0.052 13.6 13.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pannexin_like PF12534.8 CDI86060.1 - 0.049 12.7 0.9 0.061 12.4 0.9 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Dopey_N PF04118.14 CDI86060.1 - 0.095 11.8 1.5 0.12 11.5 1.5 1.1 1 0 0 1 1 1 0 Dopey, N-terminal Roughex PF06020.11 CDI86060.1 - 5.9 5.9 8.4 6.3 5.8 8.4 1.1 1 0 0 1 1 1 0 Drosophila roughex protein DUF2722 PF10846.8 CDI86061.1 - 0.00015 20.8 2.5 0.00015 20.8 2.5 3.7 3 1 1 4 4 4 1 Protein of unknown function (DUF2722) G0-G1_switch_2 PF15103.6 CDI86061.1 - 0.0049 17.3 0.4 0.0049 17.3 0.4 2.9 3 0 0 3 3 3 1 G0/G1 switch protein 2 Lin-8 PF03353.15 CDI86061.1 - 0.006 16.2 12.7 0.006 16.2 12.7 2.9 3 0 0 3 3 3 2 Ras-mediated vulval-induction antagonist PepSY_TM PF03929.16 CDI86061.1 - 0.06 13.0 0.1 0.06 13.0 0.1 3.9 2 2 1 3 3 3 0 PepSY-associated TM region DUF3464 PF11947.8 CDI86061.1 - 0.13 12.0 0.1 0.13 12.0 0.1 3.2 3 1 0 3 3 3 0 Photosynthesis affected mutant 68 eIF-3_zeta PF05091.12 CDI86061.1 - 1.2 8.1 26.8 0.71 8.8 1.4 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM176 PF14851.6 CDI86061.1 - 2 8.1 9.8 1.5 8.5 0.1 2.6 2 0 0 2 2 2 0 FAM176 family AAA_23 PF13476.6 CDI86061.1 - 3.8 7.9 21.5 3.3 8.2 12.2 2.2 2 0 0 2 2 2 0 AAA domain SpoIIP PF07454.11 CDI86061.1 - 5.9 6.3 21.3 0.46 9.9 7.2 2.5 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) VEK-30 PF12107.8 CDI86062.1 - 4.5 7.3 7.2 6.8 6.7 0.9 2.8 2 0 0 2 2 2 0 Plasminogen (Pg) ligand in fibrinolytic pathway DUF4366 PF14283.6 CDI86063.1 - 0.12 12.4 4.9 0.13 12.3 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Connexin PF00029.19 CDI86063.1 - 0.32 10.7 10.4 0.39 10.4 10.4 1.1 1 0 0 1 1 1 0 Connexin Afi1 PF07792.12 CDI86063.1 - 0.97 9.9 13.6 1.1 9.7 13.6 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Sec62 PF03839.16 CDI86063.1 - 1.6 8.2 13.4 1.6 8.2 13.4 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 MAT1 PF06391.13 CDI86063.1 - 1.8 8.3 22.8 2.2 8.1 22.8 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF2828 PF11443.8 CDI86063.1 - 2 6.4 13.0 2 6.4 13.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) OATP PF03137.20 CDI86063.1 - 2.3 6.4 8.3 2.5 6.3 8.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3616 PF12275.8 CDI86063.1 - 2.6 7.4 11.4 2.8 7.3 11.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3616) Kei1 PF08552.11 CDI86063.1 - 3.3 7.5 7.9 3.7 7.4 7.9 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 FAM60A PF15396.6 CDI86063.1 - 3.7 7.5 10.1 4.4 7.2 10.1 1.2 1 0 0 1 1 1 0 Protein Family FAM60A ORC_WH_C PF18137.1 CDI86063.1 - 4.4 7.4 13.7 5.7 7.0 13.7 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal V_ATPase_I PF01496.19 CDI86063.1 - 5 4.9 15.9 5 4.9 15.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI86063.1 - 5.1 6.0 12.4 5.5 5.9 12.4 1.0 1 0 0 1 1 1 0 CLN3 protein Tim54 PF11711.8 CDI86063.1 - 5.2 5.8 11.6 5.7 5.6 11.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Membralin PF09746.9 CDI86063.1 - 6 5.8 10.5 6.4 5.7 10.5 1.0 1 0 0 1 1 1 0 Tumour-associated protein PPL5 PF18168.1 CDI86063.1 - 7.4 5.8 10.2 7.8 5.7 10.2 1.1 1 0 0 1 1 1 0 Prim-pol family 5 ALMT PF11744.8 CDI86063.1 - 8.3 5.1 11.7 8.3 5.1 11.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Folliculin PF11704.8 CDI86063.1 - 9 6.1 12.7 10 6.0 12.7 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Gti1_Pac2 PF09729.9 CDI86063.1 - 9.4 6.3 12.1 11 6.1 12.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family AbLIM_anchor PF16182.5 CDI86063.1 - 9.5 5.9 12.5 9.9 5.9 12.5 1.0 1 0 0 1 1 1 0 Putative adherens-junction anchoring region of AbLIM Peptidase_S49_N PF08496.10 CDI86064.1 - 3.8 7.6 22.2 4.4 7.4 22.2 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal HSP70 PF00012.20 CDI86064.1 - 4.5 5.3 16.1 4.6 5.3 16.1 1.0 1 0 0 1 1 1 0 Hsp70 protein SR-25 PF10500.9 CDI86065.1 - 4.5e-05 23.2 11.4 4.5e-05 23.2 11.4 6.3 6 1 1 7 7 7 3 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI86065.1 - 0.00012 21.2 6.5 0.00012 21.2 6.5 6.7 5 2 0 5 5 5 2 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI86065.1 - 0.0037 16.9 17.7 0.0037 16.9 17.7 6.8 5 3 1 6 6 6 2 Spt20 family ESM4 PF15952.5 CDI86065.1 - 0.0074 16.7 83.7 0.31 11.5 1.7 5.4 5 0 0 5 5 5 4 Enhancer of split M4 family RskA PF10099.9 CDI86065.1 - 0.01 16.2 4.4 0.01 16.2 4.4 8.6 4 2 3 7 7 7 0 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI86065.1 - 0.012 15.7 8.6 0.012 15.7 8.6 10.8 7 3 2 9 9 9 0 Unstructured region C-term to UIM in Ataxin3 DUF2407_C PF13373.6 CDI86065.1 - 0.012 15.7 3.6 0.012 15.7 3.6 4.9 5 0 0 5 5 5 0 DUF2407 C-terminal domain MMR1 PF08505.10 CDI86065.1 - 8.6 6.6 90.0 0.57 10.4 15.2 5.3 5 0 0 5 5 5 0 Mitochondrial Myo2 receptor-related protein SF3b10 PF07189.11 CDI86066.1 - 1.2e-17 63.8 0.0 2.4e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) Roughex PF06020.11 CDI86066.1 - 0.02 14.0 2.7 0.023 13.8 2.7 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Ribosomal_S27 PF01599.19 CDI86066.1 - 0.1 12.8 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S27a DUF3138 PF11336.8 CDI86066.1 - 0.16 10.6 3.9 0.15 10.7 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) THOC2_N PF16134.5 CDI86066.1 - 0.6 8.7 5.4 0.72 8.4 5.4 1.2 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Activator_LAG-3 PF11498.8 CDI86067.1 - 0.03 13.3 30.2 0.032 13.2 30.2 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 AAA_23 PF13476.6 CDI86067.1 - 0.11 13.0 7.6 0.1 13.1 7.6 1.0 1 0 0 1 1 1 0 AAA domain Neuregulin PF02158.15 CDI86067.1 - 0.21 10.9 11.4 0.23 10.8 11.4 1.0 1 0 0 1 1 1 0 Neuregulin intracellular region RskA PF10099.9 CDI86067.1 - 0.41 10.9 28.9 0.46 10.8 28.9 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA FHIPEP PF00771.20 CDI86067.1 - 0.91 7.9 10.5 0.93 7.9 10.5 1.0 1 0 0 1 1 1 0 FHIPEP family DUF2232 PF09991.9 CDI86067.1 - 1.2 8.2 6.9 1.3 8.1 6.9 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) OATP PF03137.20 CDI86067.1 - 1.3 7.2 6.0 1.5 7.0 6.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family NEMP PF10225.9 CDI86067.1 - 1.5 8.4 4.5 1.6 8.4 4.5 1.0 1 0 0 1 1 1 0 NEMP family Hydin_ADK PF17213.3 CDI86067.1 - 1.6 9.0 17.2 1.7 8.9 17.2 1.0 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain R_equi_Vir PF05526.11 CDI86067.1 - 2.6 7.9 14.8 2.9 7.7 14.8 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein TPP_enzyme_N PF02776.18 CDI86067.1 - 3.4 7.3 13.9 4 7.0 13.9 1.1 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TMEM174 PF15029.6 CDI86067.1 - 4.2 7.0 8.7 4.3 7.0 8.7 1.0 1 0 0 1 1 1 0 Transmembrane protein 174 Glt_symporter PF03616.14 CDI86067.1 - 4.4 5.9 6.0 5.2 5.6 6.0 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter Suf PF05843.14 CDI86067.1 - 5.1 7.0 19.6 5 7.0 19.6 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Pex14_N PF04695.13 CDI86067.1 - 7.6 7.2 23.7 9 6.9 23.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region IHABP4_N PF16174.5 CDI86067.1 - 7.8 7.1 19.8 10 6.7 19.8 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal CCDC53 PF10152.9 CDI86068.1 - 0.0082 16.6 1.3 0.014 15.9 1.3 1.4 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex MID_MedPIWI PF18296.1 CDI86068.1 - 0.012 15.4 6.4 0.014 15.2 6.4 1.2 1 0 0 1 1 1 0 MID domain of medPIWI DUF4551 PF15087.6 CDI86068.1 - 0.013 14.4 6.5 0.014 14.3 6.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF3446 PF11928.8 CDI86068.1 - 0.017 15.4 29.6 0.11 12.8 17.2 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain ODV-E18 PF10717.9 CDI86068.1 - 0.028 14.3 5.8 0.028 14.3 5.8 2.4 2 0 0 2 2 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF5427 PF10310.9 CDI86068.1 - 0.033 13.2 6.5 0.037 13.0 6.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) TFIIA PF03153.13 CDI86068.1 - 0.033 14.2 7.6 0.035 14.1 7.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PE_PPE_C PF12484.8 CDI86068.1 - 0.035 15.0 8.7 0.035 15.0 8.7 2.1 2 0 0 2 2 2 0 Polymorphic PE/PPE proteins C terminal RIFIN PF02009.16 CDI86068.1 - 0.044 13.7 3.2 0.054 13.4 3.2 1.2 1 0 0 1 1 1 0 Rifin LAP1C PF05609.12 CDI86068.1 - 0.045 12.9 6.9 0.052 12.6 6.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) ASD2 PF08687.11 CDI86068.1 - 0.19 11.3 3.6 0.27 10.8 3.6 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Suf PF05843.14 CDI86068.1 - 0.29 11.1 4.6 0.31 11.0 4.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Miga PF10265.9 CDI86068.1 - 0.98 8.3 8.3 1.2 8.0 8.3 1.1 1 0 0 1 1 1 0 Mitoguardin DUF3043 PF11241.8 CDI86068.1 - 1 9.3 3.6 2.1 8.4 3.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3043) PAP1 PF08601.10 CDI86068.1 - 3.9 7.1 19.3 4.6 6.9 19.3 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 DUF4820 PF16091.5 CDI86068.1 - 5.3 6.3 11.5 3.5 6.9 9.7 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4820) GREB1 PF15782.5 CDI86068.1 - 7.3 3.6 13.5 7.4 3.5 13.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CxC5 PF18718.1 CDI86070.1 - 0.1 12.7 7.2 0.22 11.6 6.4 2.0 1 1 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases Shadoo PF14999.6 CDI86070.1 - 0.6 10.2 11.9 19 5.3 9.1 2.2 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Chorion_S16 PF05836.12 CDI86070.1 - 0.68 10.2 9.2 1.9 8.8 6.2 2.1 2 0 0 2 2 2 0 Chorion protein S16 FHIPEP PF00771.20 CDI86070.1 - 2.1 6.7 14.0 0.062 11.8 6.1 1.9 2 0 0 2 2 2 0 FHIPEP family Corona_nucleoca PF00937.18 CDI86071.1 - 0.85 8.6 10.4 1.2 8.1 10.4 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein SPX PF03105.19 CDI86071.1 - 1 9.2 9.5 1.3 8.8 9.5 1.1 1 0 0 1 1 1 0 SPX domain TFIIA PF03153.13 CDI86071.1 - 2.1 8.3 13.1 2.5 8.0 13.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NUC130_3NT PF08158.12 CDI86073.1 - 0.15 12.4 0.8 0.33 11.3 0.0 2.1 2 0 0 2 2 2 0 NUC130/3NT domain SUIM_assoc PF16619.5 CDI86074.1 - 0.17 11.9 8.0 0.21 11.7 8.0 1.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Activator_LAG-3 PF11498.8 CDI86075.1 - 0.0024 16.9 22.3 0.0024 16.9 22.3 2.2 2 0 0 2 2 2 1 Transcriptional activator LAG-3 DUF3506 PF12014.8 CDI86075.1 - 2.1 8.4 6.1 0.18 11.8 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3506) Peptidase_S49_N PF08496.10 CDI86075.1 - 2.6 8.1 19.6 0.11 12.6 5.5 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF2722 PF10846.8 CDI86076.1 - 0.0024 16.9 21.5 0.02 13.9 10.4 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) ANAPC_CDC26 PF10471.9 CDI86076.1 - 0.018 15.8 5.6 0.018 15.8 5.6 3.8 4 1 1 5 5 3 0 Anaphase-promoting complex APC subunit CDC26 RNase_H2_suC PF08615.11 CDI86076.1 - 0.057 13.6 0.6 1.9 8.6 0.2 2.2 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DUF4667 PF15700.5 CDI86076.1 - 0.11 12.6 13.6 0.031 14.4 8.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) Peptidase_S64 PF08192.11 CDI86076.1 - 0.5 8.8 13.0 0.68 8.3 13.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF4574 PF15141.6 CDI86076.1 - 0.65 9.9 12.6 10 6.1 5.7 3.3 3 0 0 3 3 3 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 DFRP_C PF16543.5 CDI86076.1 - 0.75 10.3 8.3 0.29 11.7 0.3 2.4 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 SPX PF03105.19 CDI86076.1 - 1.4 8.8 8.7 1.4 8.8 7.7 1.4 1 1 0 1 1 1 0 SPX domain RAB3GAP2_N PF14655.6 CDI86076.1 - 2.5 7.3 17.3 1.2 8.3 2.6 2.7 2 1 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus U1snRNP70_N PF12220.8 CDI86076.1 - 2.9 8.6 9.2 14 6.4 0.3 2.6 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal MID_MedPIWI PF18296.1 CDI86076.1 - 4.5 7.0 22.9 15 5.3 21.8 2.0 1 1 1 2 2 2 0 MID domain of medPIWI Phostensin_N PF13916.6 CDI86076.1 - 7.3 7.0 12.8 9.5 6.6 2.5 3.0 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal NABP PF07990.12 CDI86077.1 - 0.0099 15.5 9.4 0.014 15.0 9.4 1.3 1 0 0 1 1 1 1 Nucleic acid binding protein NABP Membralin PF09746.9 CDI86077.1 - 6.4 5.7 8.0 9.7 5.1 8.0 1.3 1 0 0 1 1 1 0 Tumour-associated protein DDHD PF02862.17 CDI86078.1 - 0.034 14.3 7.5 0.042 14.0 7.5 1.2 1 0 0 1 1 1 0 DDHD domain IER PF05760.12 CDI86078.1 - 0.06 13.6 17.0 0.067 13.5 17.0 1.0 1 0 0 1 1 1 0 Immediate early response protein (IER) INO80_Ies4 PF08193.11 CDI86078.1 - 0.21 11.6 7.7 0.3 11.0 7.7 1.2 1 0 0 1 1 1 0 INO80 complex subunit Ies4 MMR1 PF08505.10 CDI86078.1 - 0.24 11.6 19.7 0.31 11.3 19.7 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Herpes_UL87 PF03043.14 CDI86078.1 - 0.36 9.2 4.5 0.38 9.2 4.5 1.1 1 0 0 1 1 1 0 Herpesvirus UL87 family Presenilin PF01080.17 CDI86078.1 - 0.62 8.8 15.5 0.74 8.5 15.5 1.1 1 0 0 1 1 1 0 Presenilin Sin_N PF04801.13 CDI86078.1 - 0.63 9.2 22.9 0.75 8.9 22.9 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Eaf7 PF07904.13 CDI86078.1 - 0.65 10.4 6.5 0.83 10.1 6.5 1.2 1 0 0 1 1 1 0 Chromatin modification-related protein EAF7 TFIIA PF03153.13 CDI86078.1 - 0.81 9.6 38.1 1.3 8.9 38.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hist_deacetyl PF00850.19 CDI86078.1 - 0.9 9.0 6.6 1.3 8.4 6.6 1.3 1 0 0 1 1 1 0 Histone deacetylase domain Mcm10 PF09332.11 CDI86078.1 - 1 8.7 19.8 1.2 8.4 19.8 1.1 1 0 0 1 1 1 0 Mcm10 replication factor Suf PF05843.14 CDI86078.1 - 1.2 9.0 18.4 1.7 8.6 18.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2126 PF09899.9 CDI86078.1 - 1.3 7.0 7.5 1.5 6.8 7.5 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF4045 PF13254.6 CDI86078.1 - 1.6 8.3 14.3 2 8.0 14.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Menin PF05053.13 CDI86078.1 - 1.6 7.0 10.5 2 6.7 10.5 1.1 1 0 0 1 1 1 0 Menin Herpes_capsid PF06112.11 CDI86078.1 - 1.6 8.7 10.3 1.2 9.2 4.8 2.1 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein Neur_chan_memb PF02932.16 CDI86078.1 - 1.7 8.6 11.2 2.2 8.3 11.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.6 CDI86078.1 - 2.4 7.4 20.5 2.8 7.2 20.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1178 PF06676.11 CDI86078.1 - 2.5 8.5 16.4 4.2 7.7 16.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) eIF-3_zeta PF05091.12 CDI86078.1 - 2.5 7.0 16.1 3.7 6.4 16.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ALMT PF11744.8 CDI86078.1 - 2.5 6.8 12.6 3.1 6.5 12.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter PA26 PF04636.13 CDI86078.1 - 2.8 6.7 13.7 3.4 6.5 13.7 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) GAGA_bind PF06217.12 CDI86078.1 - 3.3 7.9 15.1 3.7 7.7 15.1 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Ndc1_Nup PF09531.10 CDI86078.1 - 3.7 6.1 13.7 4.1 6.0 13.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SLC12 PF03522.15 CDI86078.1 - 3.9 6.4 16.0 4.7 6.1 16.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 V_ATPase_I PF01496.19 CDI86078.1 - 4.8 5.0 15.7 5.7 4.7 15.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2828 PF11443.8 CDI86078.1 - 5.8 4.9 12.8 6.6 4.7 12.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MAT1 PF06391.13 CDI86078.1 - 6 6.6 22.7 7.9 6.2 22.7 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Membralin PF09746.9 CDI86078.1 - 6.7 5.6 10.0 7.4 5.5 10.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein RR_TM4-6 PF06459.12 CDI86078.1 - 6.8 6.4 15.2 9 6.0 15.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 hDGE_amylase PF14701.6 CDI86078.1 - 7.2 5.6 11.7 9.5 5.2 11.7 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain RRM_1 PF00076.22 CDI86080.1 - 1.1e-16 60.4 0.0 0.00074 19.3 0.0 4.7 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2722 PF10846.8 CDI86080.1 - 0.0065 15.5 6.7 0.0065 15.5 6.7 7.0 4 2 0 4 4 4 1 Protein of unknown function (DUF2722) UNC-79 PF14776.6 CDI86080.1 - 0.007 15.2 1.6 0.007 15.2 1.6 4.1 3 1 0 3 3 3 1 Cation-channel complex subunit UNC-79 Spt20 PF12090.8 CDI86080.1 - 0.012 15.3 12.9 0.012 15.3 12.9 6.8 3 2 1 4 4 4 0 Spt20 family Lin-8 PF03353.15 CDI86080.1 - 1.3 8.5 81.8 0.034 13.7 37.0 4.3 4 0 0 4 4 4 0 Ras-mediated vulval-induction antagonist AF-4 PF05110.13 CDI86081.1 - 6.1e-05 21.4 24.8 7.1e-05 21.1 24.8 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein UPF0029 PF01205.19 CDI86081.1 - 0.0062 16.9 3.9 0.01 16.2 3.9 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 LodA_N PF17990.1 CDI86081.1 - 0.11 12.5 7.5 0.13 12.1 7.5 1.1 1 0 0 1 1 1 0 L-Lysine epsilon oxidase N-terminal MAT1 PF06391.13 CDI86081.1 - 0.11 12.3 21.7 0.16 11.8 21.7 1.3 1 1 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Cwf_Cwc_15 PF04889.12 CDI86081.1 - 0.12 12.1 11.1 0.15 11.7 11.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Macoilin PF09726.9 CDI86081.1 - 0.26 9.8 19.1 0.31 9.5 19.1 1.0 1 0 0 1 1 1 0 Macoilin family Allexi_40kDa PF05549.11 CDI86081.1 - 0.28 10.6 13.2 0.4 10.2 13.2 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein Put_Phosphatase PF06888.12 CDI86081.1 - 0.28 10.5 3.4 0.37 10.2 3.4 1.1 1 0 0 1 1 1 0 Putative Phosphatase TFIIA PF03153.13 CDI86081.1 - 0.38 10.7 37.5 0.47 10.4 37.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CDI86081.1 - 0.52 9.8 20.6 0.64 9.5 20.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SPX PF03105.19 CDI86081.1 - 0.55 10.1 21.3 0.67 9.8 21.3 1.0 1 0 0 1 1 1 0 SPX domain DUF1151 PF06625.11 CDI86081.1 - 0.68 9.9 19.5 1.1 9.2 19.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) GREB1 PF15782.5 CDI86081.1 - 0.95 6.5 24.9 1.1 6.3 24.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Utp14 PF04615.13 CDI86081.1 - 0.98 7.9 16.1 1.1 7.7 16.1 1.0 1 0 0 1 1 1 0 Utp14 protein Apt1 PF10351.9 CDI86081.1 - 1.3 7.8 17.1 1.5 7.6 17.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Menin PF05053.13 CDI86081.1 - 1.4 7.2 14.6 1.6 7.0 14.6 1.1 1 0 0 1 1 1 0 Menin FapA PF03961.13 CDI86081.1 - 1.8 7.1 8.9 2 6.9 8.9 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4407 PF14362.6 CDI86081.1 - 2 7.7 14.1 2.3 7.5 14.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PepSY_TM PF03929.16 CDI86081.1 - 2.8 7.5 5.5 3.3 7.3 5.5 1.2 1 0 0 1 1 1 0 PepSY-associated TM region Ureide_permease PF07168.11 CDI86081.1 - 3 6.5 6.1 3.7 6.2 6.1 1.3 1 0 0 1 1 1 0 Ureide permease PAT1 PF09770.9 CDI86081.1 - 4 5.6 26.7 4.7 5.4 26.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 V_ATPase_I PF01496.19 CDI86081.1 - 4.8 5.0 12.1 5.4 4.8 12.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF572 PF04502.13 CDI86081.1 - 5.4 6.5 17.6 6.6 6.2 17.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Miga PF10265.9 CDI86081.1 - 6.3 5.7 16.9 7.6 5.4 16.9 1.0 1 0 0 1 1 1 0 Mitoguardin Neur_chan_memb PF02932.16 CDI86081.1 - 8.4 6.4 12.6 12 5.9 12.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GET2 PF08690.10 CDI86082.1 - 0.00053 19.8 19.1 0.00053 19.8 19.1 1.4 2 0 0 2 2 2 1 GET complex subunit GET2 DUF4386 PF14329.6 CDI86082.1 - 0.0056 16.6 3.7 0.0056 16.6 3.7 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4386) RIFIN PF02009.16 CDI86082.1 - 0.017 15.1 12.8 0.022 14.7 12.8 1.1 1 0 0 1 1 1 0 Rifin CitMHS_2 PF16980.5 CDI86082.1 - 0.16 10.6 0.1 9.2 4.8 0.1 2.1 2 0 0 2 2 2 0 Putative citrate transport IPK PF03770.16 CDI86082.1 - 0.2 11.5 16.0 0.25 11.2 16.0 1.4 1 1 0 1 1 1 0 Inositol polyphosphate kinase KilA-N PF04383.13 CDI86082.1 - 1.4 8.8 9.7 2.1 8.2 9.7 1.4 1 0 0 1 1 1 0 KilA-N domain DUF5345 PF17280.2 CDI86082.1 - 1.7 8.7 0.0 1.7 8.7 0.0 4.2 3 1 1 4 4 4 0 Family of unknown function (DUF5345) Peptidase_S46 PF10459.9 CDI86082.1 - 2.8 6.5 23.9 3.5 6.2 23.9 1.1 1 0 0 1 1 1 0 Peptidase S46 Presenilin PF01080.17 CDI86082.1 - 4.3 6.0 18.8 6.5 5.4 18.8 1.4 1 0 0 1 1 1 0 Presenilin DUF5527 PF17665.1 CDI86082.1 - 5.2 6.6 7.1 2.7 7.5 4.6 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5527) FAM60A PF15396.6 CDI86082.1 - 8.8 6.3 13.3 16 5.4 13.3 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Orf78 PF06024.12 CDI86083.1 - 0.63 10.4 7.2 0.12 12.7 2.3 1.8 1 1 1 2 2 2 0 Orf78 (ac78) Plasmodium_Vir PF05795.11 CDI86083.1 - 0.73 9.2 12.1 0.83 9.0 12.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein FAM76 PF16046.5 CDI86083.1 - 0.9 8.8 8.3 0.95 8.8 8.3 1.0 1 0 0 1 1 1 0 FAM76 protein PEHE PF15275.6 CDI86083.1 - 0.94 10.1 9.1 1.2 9.8 9.1 1.2 1 0 0 1 1 1 0 PEHE domain Apt1 PF10351.9 CDI86083.1 - 1.2 7.9 15.0 1.4 7.7 15.0 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain CAC1F_C PF16885.5 CDI86083.1 - 1.9 8.1 6.3 2.2 7.9 6.3 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term SPX PF03105.19 CDI86083.1 - 3.5 7.4 13.3 4.7 7.0 13.3 1.1 1 0 0 1 1 1 0 SPX domain NST1 PF13945.6 CDI86083.1 - 6.3 6.9 14.9 7.6 6.6 14.9 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Ctr PF04145.15 CDI86083.1 - 7 7.2 7.5 14 6.3 7.5 1.6 1 1 0 1 1 1 0 Ctr copper transporter family DUF1645 PF07816.11 CDI86084.1 - 0.0041 17.7 0.1 0.0041 17.7 0.1 4.8 3 1 1 5 5 5 1 Protein of unknown function (DUF1645) Dicty_REP PF05086.12 CDI86084.1 - 1.4 6.8 10.1 2 6.3 10.1 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DOR PF14839.6 CDI86085.1 - 0.046 13.7 12.8 0.065 13.2 12.8 1.2 1 0 0 1 1 1 0 DOR family TFIIA PF03153.13 CDI86085.1 - 0.37 10.7 13.9 0.47 10.4 13.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI86085.1 - 1 8.9 10.1 1.3 8.6 10.1 1.2 1 0 0 1 1 1 0 Spt20 family Apt1 PF10351.9 CDI86085.1 - 1.5 7.6 7.1 1.8 7.4 7.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 CDI86085.1 - 2.9 7.4 6.2 3.7 7.0 6.2 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist IHABP4_N PF16174.5 CDI86085.1 - 4.8 7.8 14.2 7.7 7.1 14.2 1.3 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Macoilin PF09726.9 CDI86085.1 - 7.7 4.9 13.8 10 4.5 13.8 1.1 1 0 0 1 1 1 0 Macoilin family DUF2722 PF10846.8 CDI86086.1 - 0.00053 19.0 46.1 0.00059 18.9 12.9 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI86086.1 - 0.0016 19.1 3.4 0.0016 19.1 3.4 3.3 3 0 0 3 3 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region Band_3_cyto PF07565.13 CDI86086.1 - 0.0034 17.2 1.6 0.0034 17.2 1.6 2.2 2 0 0 2 2 2 1 Band 3 cytoplasmic domain RNase_H2_suC PF08615.11 CDI86086.1 - 0.0056 16.9 4.1 0.34 11.1 0.3 2.3 2 0 0 2 2 2 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) EPL1 PF10513.9 CDI86086.1 - 0.0067 16.8 17.2 0.13 12.7 4.3 2.3 2 0 0 2 2 2 2 Enhancer of polycomb-like TCP PF03634.13 CDI86086.1 - 0.0071 16.9 13.5 0.42 11.2 3.3 2.5 2 0 0 2 2 2 2 TCP family transcription factor Spt20 PF12090.8 CDI86086.1 - 0.0091 15.6 61.7 0.096 12.3 25.2 2.2 2 0 0 2 2 2 2 Spt20 family HNOBA PF07701.14 CDI86086.1 - 0.01 15.3 5.0 0.97 8.8 0.2 2.2 2 0 0 2 2 2 2 Heme NO binding associated RskA PF10099.9 CDI86086.1 - 0.015 15.6 46.8 0.42 10.9 3.1 3.4 2 1 0 2 2 2 0 Anti-sigma-K factor rskA PNISR PF15996.5 CDI86086.1 - 0.018 15.3 26.0 0.44 10.8 10.0 2.4 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Suf PF05843.14 CDI86086.1 - 0.024 14.6 23.9 0.32 10.9 7.2 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) MMR1 PF08505.10 CDI86086.1 - 0.025 14.9 18.9 0.08 13.2 3.7 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein eIF-3_zeta PF05091.12 CDI86086.1 - 0.029 13.4 25.9 0.17 10.8 10.7 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CTNNB1_binding PF08347.11 CDI86086.1 - 0.037 14.2 11.4 0.6 10.3 2.0 2.3 2 0 0 2 2 2 0 N-terminal CTNNB1 binding DUF2052 PF09747.9 CDI86086.1 - 0.038 14.1 19.0 0.079 13.1 6.8 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Presenilin PF01080.17 CDI86086.1 - 0.044 12.5 21.2 0.19 10.4 4.3 2.2 2 0 0 2 2 2 0 Presenilin EOS1 PF12326.8 CDI86086.1 - 0.05 13.5 3.6 3.5 7.5 0.1 2.2 2 0 0 2 2 2 0 N-glycosylation protein Gti1_Pac2 PF09729.9 CDI86086.1 - 0.051 13.7 10.8 0.39 10.8 0.8 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family PAT1 PF09770.9 CDI86086.1 - 0.092 11.0 27.4 0.11 10.7 6.3 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 LTV PF04180.14 CDI86086.1 - 0.1 12.3 14.0 0.64 9.7 3.9 2.1 2 0 0 2 2 2 0 Low temperature viability protein UPF0560 PF10577.9 CDI86086.1 - 0.13 10.7 28.5 0.047 12.2 8.7 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 SID-1_RNA_chan PF13965.6 CDI86086.1 - 0.14 10.5 0.4 4 5.7 0.0 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DAG_kinase_N PF14513.6 CDI86086.1 - 0.15 12.3 14.0 1.1 9.4 1.1 2.4 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Spore_YhcN_YlaJ PF09580.10 CDI86086.1 - 0.16 12.0 14.5 1.6 8.8 6.6 2.2 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) MecA PF05389.12 CDI86086.1 - 0.19 11.4 13.7 0.85 9.2 3.3 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) CDC45 PF02724.14 CDI86086.1 - 0.27 9.5 13.7 0.48 8.7 4.7 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF4834 PF16118.5 CDI86086.1 - 0.27 12.2 28.4 1 10.4 8.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) NPR3 PF03666.13 CDI86086.1 - 0.29 9.9 13.9 0.08 11.7 1.3 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Roughex PF06020.11 CDI86086.1 - 0.47 9.5 26.6 0.62 9.1 7.0 2.5 2 0 0 2 2 2 0 Drosophila roughex protein FAM60A PF15396.6 CDI86086.1 - 0.48 10.4 16.2 1.3 9.0 4.7 2.3 2 0 0 2 2 2 0 Protein Family FAM60A DUF4628 PF15429.6 CDI86086.1 - 0.48 10.1 15.7 2.4 7.7 5.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4628) HemX PF04375.14 CDI86086.1 - 0.5 9.6 31.0 0.028 13.7 5.8 2.2 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase SAPS PF04499.15 CDI86086.1 - 0.71 8.6 12.0 1.8 7.3 4.4 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Connexin PF00029.19 CDI86086.1 - 0.73 9.6 14.6 0.67 9.7 3.0 2.2 2 0 0 2 2 2 0 Connexin DUF3807 PF12720.7 CDI86086.1 - 0.8 9.9 28.6 2.4 8.4 6.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Sec62 PF03839.16 CDI86086.1 - 0.89 9.0 13.6 0.5 9.8 2.2 2.3 2 0 0 2 2 2 0 Translocation protein Sec62 DUF5327 PF17261.2 CDI86086.1 - 0.95 10.3 31.1 4.4 8.1 9.4 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5327) Rrp15p PF07890.12 CDI86086.1 - 1.2 9.5 20.5 1.6 9.1 4.3 2.7 2 0 0 2 2 2 0 Rrp15p Rxt3 PF08642.10 CDI86086.1 - 1.3 9.9 12.7 5.2 7.8 3.8 2.4 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 Peptidase_C58 PF03543.14 CDI86086.1 - 1.3 8.6 21.9 0.4 10.4 5.5 2.4 2 0 0 2 2 2 0 Yersinia/Haemophilus virulence surface antigen DUF1764 PF08576.10 CDI86086.1 - 1.4 9.9 19.7 2.6 9.0 3.6 2.6 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) DUF4471 PF14740.6 CDI86086.1 - 1.4 8.0 10.8 2 7.6 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) Plasmodium_Vir PF05795.11 CDI86086.1 - 1.6 8.1 14.0 2.9 7.2 1.7 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Ctr PF04145.15 CDI86086.1 - 1.6 9.4 9.2 5.4 7.6 0.8 2.5 2 0 0 2 2 2 0 Ctr copper transporter family SpoIIP PF07454.11 CDI86086.1 - 1.6 8.1 24.5 2.1 7.7 5.5 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) SLC12 PF03522.15 CDI86086.1 - 1.8 7.5 17.1 2.9 6.8 5.6 2.1 2 0 0 2 2 2 0 Solute carrier family 12 MH2 PF03166.14 CDI86086.1 - 2 8.6 11.3 1.2 9.3 2.2 2.4 2 0 0 2 2 2 0 MH2 domain Eapp_C PF10238.9 CDI86086.1 - 2.6 8.1 25.4 5.1 7.2 9.3 2.6 2 0 0 2 2 2 0 E2F-associated phosphoprotein Afi1 PF07792.12 CDI86086.1 - 3.2 8.2 20.3 3.6 8.1 6.5 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Zip PF02535.22 CDI86086.1 - 3.3 6.8 9.5 2.7 7.1 0.9 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter MDM10 PF12519.8 CDI86086.1 - 4.1 6.2 12.8 1.5 7.6 1.6 2.1 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 Mlh1_C PF16413.5 CDI86086.1 - 4.5 6.6 11.7 2.4 7.5 0.5 2.2 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus DUF702 PF05142.12 CDI86086.1 - 4.8 7.6 22.9 0.62 10.5 3.0 2.8 3 0 0 3 3 2 0 Domain of unknown function (DUF702) RPA43_OB PF17875.1 CDI86086.1 - 5 7.8 18.1 6.1 7.5 4.2 2.6 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I MAT1 PF06391.13 CDI86086.1 - 5.4 6.8 26.7 6.5 6.5 7.6 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Dynamin_N PF00350.23 CDI86086.1 - 5.6 7.0 7.6 20 5.2 2.3 2.2 2 0 0 2 2 2 0 Dynamin family MPM1 PF17234.2 CDI86086.1 - 5.7 7.2 24.3 5.4 7.3 6.3 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF2828 PF11443.8 CDI86086.1 - 5.9 4.9 15.4 1.2 7.1 0.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) CTU2 PF10288.9 CDI86086.1 - 5.9 7.2 21.6 4.8 7.5 5.1 2.6 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Nop53 PF07767.11 CDI86086.1 - 6.3 6.1 28.2 1.1 8.5 6.7 2.2 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) TFB6 PF17110.5 CDI86086.1 - 6.9 6.4 16.5 5.1 6.8 2.0 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF2126 PF09899.9 CDI86086.1 - 7.5 4.5 12.1 2.5 6.1 0.9 2.1 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) DUF908 PF06012.12 CDI86086.1 - 7.6 5.8 12.5 2 7.8 1.2 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) DUF5385 PF17359.2 CDI86086.1 - 7.6 6.0 22.4 7 6.1 8.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5385) DUF4484 PF14831.6 CDI86086.1 - 8 6.4 16.6 11 5.9 7.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) Ank_5 PF13857.6 CDI86087.1 - 1.5e-19 69.8 0.3 4.4e-13 49.2 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDI86087.1 - 4.2e-14 52.7 0.0 1.8e-10 41.1 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDI86087.1 - 6.9e-12 45.8 0.0 1.6e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CDI86087.1 - 3.3e-11 43.1 0.1 5e-05 23.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 CDI86087.1 - 7.1e-10 38.3 0.0 0.0015 18.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat ACBP PF00887.19 CDI86087.1 - 0.00015 21.9 0.1 0.00029 21.0 0.1 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein Presenilin PF01080.17 CDI86088.1 - 0.46 9.2 2.0 0.91 8.2 2.0 1.4 1 0 0 1 1 1 0 Presenilin Shugoshin_N PF07558.11 CDI86089.1 - 0.07 13.0 1.2 0.16 11.9 1.2 1.5 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region DUF3037 PF11236.8 CDI86089.1 - 0.47 10.9 1.9 2.1 8.8 0.2 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3037) SpoIIP PF07454.11 CDI86089.1 - 3.6 7.0 10.3 5.7 6.3 10.3 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CDI86089.1 - 4.3 6.0 13.0 7.3 5.2 13.0 1.3 1 0 0 1 1 1 0 Presenilin Diphthami_syn_2 PF01902.17 CDI86092.1 - 5.8e-32 111.0 0.0 1.5e-31 109.6 0.0 1.6 1 1 0 1 1 1 1 Diphthamide synthase AAA PF00004.29 CDI86093.1 - 1.4e-38 132.3 0.0 2.7e-38 131.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CDI86093.1 - 1.4e-22 79.4 0.1 3.4e-22 78.2 0.1 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 CDI86093.1 - 3.3e-10 39.6 0.1 1.3e-07 31.3 0.0 3.1 2 1 1 3 3 3 1 AAA+ lid domain MIT PF04212.18 CDI86093.1 - 2.8e-07 30.5 0.1 0.018 15.1 0.0 2.6 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain RuvB_N PF05496.12 CDI86093.1 - 6.1e-05 22.8 0.0 0.00018 21.3 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 CDI86093.1 - 0.00025 20.8 0.0 0.00047 19.9 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 CDI86093.1 - 0.0016 18.5 0.0 0.003 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CDI86093.1 - 0.0029 17.2 0.2 2.6 7.6 0.1 2.9 2 1 0 3 3 3 2 AAA domain AAA_22 PF13401.6 CDI86093.1 - 0.0051 17.1 0.1 0.16 12.2 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 CDI86093.1 - 0.0066 16.6 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CDI86093.1 - 0.015 15.5 0.0 0.076 13.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CDI86093.1 - 0.017 15.5 0.1 7.2 7.0 0.0 3.2 2 1 1 3 3 3 0 AAA ATPase domain AAA_5 PF07728.14 CDI86093.1 - 0.036 14.1 1.1 0.13 12.2 0.1 2.5 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) PSK_trans_fac PF07704.11 CDI86093.1 - 0.22 12.3 1.1 8.8 7.2 0.0 3.1 3 0 0 3 3 2 0 Rv0623-like transcription factor DnaJ PF00226.31 CDI86094.1 - 6.1e-19 67.9 1.0 1.6e-17 63.4 1.0 2.5 1 1 0 1 1 1 1 DnaJ domain DUF1631 PF07793.11 CDI86094.1 - 0.13 10.7 4.4 0.13 10.7 4.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Ccdc124 PF06244.12 CDI86095.1 - 6.9e-25 88.1 24.2 4.5e-22 79.0 24.2 2.3 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 LtuB PF17455.2 CDI86095.1 - 0.32 11.6 1.8 0.53 10.9 0.7 1.9 2 0 0 2 2 2 0 Late transcription unit B Dynamin_N PF00350.23 CDI86095.1 - 0.62 10.1 2.6 1.2 9.2 2.5 1.6 1 1 0 1 1 1 0 Dynamin family DUF2951 PF11166.8 CDI86095.1 - 1.1 9.5 4.9 2.2 8.6 4.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) YabA PF06156.13 CDI86096.1 - 0.013 16.1 3.2 0.013 16.1 3.2 3.5 1 1 2 3 3 3 0 Initiation control protein YabA TSC22 PF01166.18 CDI86096.1 - 0.022 15.1 2.8 0.022 15.1 2.8 2.6 2 0 0 2 2 2 0 TSC-22/dip/bun family AnfO_nitrog PF09582.10 CDI86096.1 - 0.17 11.2 2.1 0.33 10.3 2.1 1.5 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) Golgin_A5 PF09787.9 CDI86096.1 - 0.24 10.8 29.2 0.014 14.8 19.1 2.5 1 1 1 2 2 2 0 Golgin subfamily A member 5 PKcGMP_CC PF16808.5 CDI86096.1 - 0.67 9.9 3.4 2 8.3 3.4 1.8 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase NRBF2 PF08961.10 CDI86096.1 - 1.1 8.8 18.2 0.19 11.3 9.9 2.8 1 1 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator MIP-T3_C PF17749.1 CDI86096.1 - 1.3 9.0 13.7 0.55 10.2 6.2 3.1 1 1 1 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region HALZ PF02183.18 CDI86096.1 - 1.4 9.2 5.9 0.14 12.4 1.0 1.8 2 0 0 2 2 1 0 Homeobox associated leucine zipper PHM7_cyt PF14703.6 CDI86096.1 - 1.5 9.1 6.7 6.4 7.0 6.7 2.1 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DUF641 PF04859.12 CDI86096.1 - 2 8.7 15.7 0.33 11.3 8.0 2.9 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) Seryl_tRNA_N PF02403.22 CDI86096.1 - 3 8.1 17.4 9 6.6 10.9 2.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Fungal_TACC PF12709.7 CDI86096.1 - 6.7 7.2 6.5 84 3.7 0.0 2.9 2 1 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins MAD PF05557.13 CDI86096.1 - 6.8 4.9 28.0 15 3.8 27.9 1.6 1 1 0 1 1 1 0 Mitotic checkpoint protein FlaC_arch PF05377.11 CDI86096.1 - 7.7 7.0 6.0 7.7 7.0 2.6 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) YlqD PF11068.8 CDI86096.1 - 7.8 6.9 18.3 1.1 9.7 13.0 2.3 1 1 1 2 2 2 0 YlqD protein CENP-F_leu_zip PF10473.9 CDI86096.1 - 7.9 6.5 31.3 0.33 11.0 4.4 3.5 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HAUS-augmin3 PF14932.6 CDI86096.1 - 8.2 5.9 29.1 1.7 8.2 17.0 2.7 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 Presenilin PF01080.17 CDI86097.1 - 0.097 11.4 30.8 0.15 10.8 30.8 1.2 1 0 0 1 1 1 0 Presenilin SCAI PF12070.8 CDI86097.1 - 0.16 10.8 23.7 0.2 10.5 23.7 1.1 1 0 0 1 1 1 0 Protein SCAI CCSAP PF15748.5 CDI86097.1 - 0.43 10.7 30.7 0.67 10.1 30.7 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 CDI86097.1 - 0.82 8.6 29.1 1.1 8.1 29.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 EFTUD2 PF16004.5 CDI86097.1 - 2 9.0 30.4 5.6 7.6 13.6 2.2 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus ICA69 PF04629.14 CDI86097.1 - 3.8 7.8 30.4 1.7 8.9 8.8 2.0 2 0 0 2 2 2 0 Islet cell autoantigen ICA69, C-terminal domain AIF_C PF14721.6 CDI86097.1 - 9 6.7 23.2 3.5 8.0 8.7 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4175 PF13779.6 CDI86100.1 - 3.8 5.3 46.2 1.9 6.3 6.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) Presenilin PF01080.17 CDI86101.1 - 0.17 10.6 42.0 0.22 10.3 42.0 1.3 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI86101.1 - 0.22 11.3 35.9 0.24 11.2 35.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PA26 PF04636.13 CDI86101.1 - 0.41 9.5 26.4 0.46 9.4 26.4 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) LYRIC PF15686.5 CDI86101.1 - 0.66 9.5 28.4 0.77 9.2 28.4 1.0 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family CCSAP PF15748.5 CDI86101.1 - 1.1 9.4 46.0 1.3 9.2 46.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4045 PF13254.6 CDI86101.1 - 1.4 8.5 35.2 1.6 8.3 35.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CDC45 PF02724.14 CDI86101.1 - 1.8 6.8 35.9 2 6.6 35.9 1.1 1 0 0 1 1 1 0 CDC45-like protein RIFIN PF02009.16 CDI86101.1 - 2 8.3 28.4 2.3 8.1 28.4 1.1 1 0 0 1 1 1 0 Rifin PAT1 PF09770.9 CDI86101.1 - 4.3 5.5 59.5 5 5.3 59.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AMP-binding PF00501.28 CDI86101.1 - 4.9 5.6 9.6 5.7 5.4 9.6 1.2 1 0 0 1 1 1 0 AMP-binding enzyme ALMT PF11744.8 CDI86101.1 - 5.5 5.7 29.1 6.8 5.4 29.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter GAGA_bind PF06217.12 CDI86101.1 - 7 6.8 30.6 8.1 6.6 30.6 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Macoilin PF09726.9 CDI86101.1 - 7.2 5.0 32.6 9.3 4.7 32.6 1.1 1 0 0 1 1 1 0 Macoilin family Paramyxo_ncap PF00973.19 CDI86101.1 - 8.7 5.1 29.6 11 4.9 29.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein CAC1F_C PF16885.5 CDI86101.1 - 9.2 5.8 28.2 10 5.6 28.2 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term DUF2722 PF10846.8 CDI86102.1 - 0.0018 17.3 4.0 0.0018 17.3 4.0 6.0 4 2 2 6 6 6 2 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI86102.1 - 0.0099 15.5 9.3 0.0099 15.5 9.3 6.2 4 2 1 5 5 5 2 Spt20 family SR-25 PF10500.9 CDI86103.1 - 0.014 15.1 2.9 0.015 14.9 2.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.19 CDI86103.1 - 0.032 14.8 6.7 0.07 13.7 6.7 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein ODV-E18 PF10717.9 CDI86103.1 - 0.2 11.5 0.7 0.39 10.6 0.7 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF755 PF05501.11 CDI86103.1 - 1.3 9.3 10.3 2.3 8.5 10.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Tim54 PF11711.8 CDI86104.1 - 0.0018 17.1 0.9 0.039 12.8 0.0 2.0 2 0 0 2 2 2 1 Inner membrane protein import complex subunit Tim54 Ribosomal_60s PF00428.19 CDI86104.1 - 0.03 14.9 18.5 0.062 13.9 17.0 2.3 2 1 0 2 2 2 0 60s Acidic ribosomal protein AstB PF04996.12 CDI86104.1 - 0.11 11.2 4.3 0.13 10.9 4.3 1.1 1 0 0 1 1 1 0 Succinylarginine dihydrolase Apt1 PF10351.9 CDI86104.1 - 0.15 10.9 7.3 0.15 10.9 7.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF3138 PF11336.8 CDI86104.1 - 0.52 8.9 4.4 0.66 8.5 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) RAP1 PF07218.11 CDI86104.1 - 1.4 7.1 9.9 1.8 6.7 9.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF3597 PF12200.8 CDI86104.1 - 2.5 8.7 7.6 0.52 10.9 3.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) Secretin_N_2 PF07655.13 CDI86104.1 - 2.7 8.6 16.7 4.8 7.8 16.7 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain DUF2057 PF09829.9 CDI86104.1 - 4.8 7.3 7.5 0.39 10.8 2.5 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) Corona_nucleoca PF00937.18 CDI86104.1 - 6.3 5.7 8.9 8.2 5.4 8.9 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein ACDC PF14733.6 CDI86105.1 - 9.8e-17 61.1 0.1 9.8e-17 61.1 0.1 2.1 2 0 0 2 2 2 1 AP2-coincident C-terminal AP2 PF00847.20 CDI86105.1 - 5.1e-12 45.8 11.0 3.7e-08 33.5 0.2 3.5 3 0 0 3 3 3 2 AP2 domain MID_MedPIWI PF18296.1 CDI86106.1 - 0.0023 17.7 3.4 0.003 17.4 3.4 1.2 1 0 0 1 1 1 1 MID domain of medPIWI DUF4834 PF16118.5 CDI86106.1 - 0.021 15.8 11.8 0.27 12.2 2.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Neur_chan_memb PF02932.16 CDI86106.1 - 1.4 9.0 6.6 2.1 8.3 6.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI86106.1 - 1.5 7.5 11.2 2.4 6.9 11.2 1.3 1 0 0 1 1 1 0 Presenilin DUF4571 PF15137.6 CDI86106.1 - 4.4 6.9 5.1 6.6 6.3 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4571) Hydin_ADK PF17213.3 CDI86106.1 - 4.6 7.5 9.0 11 6.2 9.0 1.6 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF2877 PF11392.8 CDI86106.1 - 4.7 8.0 5.9 7 7.4 5.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2877) V_ATPase_I PF01496.19 CDI86106.1 - 4.8 5.0 10.6 6.5 4.5 10.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family tRNA_lig_CPD PF08302.11 CDI86106.1 - 5.2 6.4 11.3 1.9 7.9 1.7 2.3 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain FlaG PF03646.15 CDI86106.1 - 6.1 7.1 19.4 13 6.1 3.6 2.7 2 0 0 2 2 2 0 FlaG protein DUF3464 PF11947.8 CDI86106.1 - 6.1 6.6 9.3 6 6.6 1.2 2.7 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 TFIIA PF03153.13 CDI86108.1 - 0.00058 20.0 60.7 0.0014 18.7 41.8 2.3 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit eIF3_subunit PF08597.10 CDI86108.1 - 0.011 15.6 24.0 0.011 15.6 24.0 3.0 3 1 1 4 4 4 0 Translation initiation factor eIF3 subunit PNISR PF15996.5 CDI86108.1 - 1.3 9.3 36.5 2.5 8.3 32.0 2.5 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Otopetrin PF03189.13 CDI86108.1 - 1.8 7.3 7.7 3.4 6.4 7.7 1.5 1 0 0 1 1 1 0 Otopetrin PAT1 PF09770.9 CDI86108.1 - 2.5 6.3 43.6 0.015 13.6 32.0 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Membralin PF09746.9 CDI86108.1 - 2.7 6.9 11.5 5.5 5.9 11.5 1.6 1 0 0 1 1 1 0 Tumour-associated protein Se-cys_synth_N PF12390.8 CDI86108.1 - 3.3 8.0 7.4 25 5.2 0.2 3.5 3 0 0 3 3 3 0 Selenocysteine synthase N terminal Zip PF02535.22 CDI86108.1 - 3.4 6.8 10.7 0.61 9.3 6.1 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter BAF1_ABF1 PF04684.13 CDI86108.1 - 4.4 6.2 28.4 1.1 8.3 16.6 2.5 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor SOBP PF15279.6 CDI86108.1 - 8.8 6.8 28.4 0.024 15.3 15.9 2.4 3 1 0 3 3 3 0 Sine oculis-binding protein Methyltransf_16 PF10294.9 CDI86109.1 - 8.6e-05 22.3 0.6 0.13 12.0 0.0 3.1 3 1 0 4 4 4 2 Lysine methyltransferase DUF4064 PF13273.6 CDI86109.1 - 0.043 14.1 0.8 0.081 13.2 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) Orf78 PF06024.12 CDI86109.1 - 0.079 13.3 0.6 0.15 12.3 0.6 1.4 1 0 0 1 1 1 0 Orf78 (ac78) SUIM_assoc PF16619.5 CDI86109.1 - 0.21 11.7 16.6 0.074 13.1 7.4 3.1 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF2207 PF09972.9 CDI86109.1 - 0.48 9.1 0.5 0.68 8.6 0.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) CAP_N PF01213.19 CDI86111.1 - 0.32 10.4 3.4 0.51 9.8 3.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal RAP1 PF07218.11 CDI86112.1 - 0.0009 17.7 4.0 0.00094 17.6 4.0 1.0 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) TFIIA PF03153.13 CDI86112.1 - 0.97 9.4 28.0 1.3 9.0 28.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.15 CDI86113.1 - 0.57 9.7 32.1 0.81 9.2 32.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit SMYLE_N PF18615.1 CDI86113.1 - 1.3 8.5 19.9 1.5 8.3 19.9 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain VIR_N PF15912.5 CDI86113.1 - 1.8 8.1 11.1 2.3 7.8 11.1 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Spt20 PF12090.8 CDI86114.1 - 0.12 11.9 15.6 0.12 12.0 15.6 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI86114.1 - 0.89 9.5 24.5 1 9.3 24.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CDI86114.1 - 5.9 7.5 18.6 8.4 7.0 18.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SR-25 PF10500.9 CDI86115.1 - 0.00096 18.8 23.0 0.00096 18.8 23.0 3.1 2 1 0 2 2 1 1 Nuclear RNA-splicing-associated protein PI3_PI4_kinase PF00454.27 CDI86115.1 - 0.0013 18.6 1.2 0.0019 18.1 0.5 1.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF755 PF05501.11 CDI86115.1 - 0.0017 18.6 31.3 0.0017 18.6 31.3 4.0 3 1 1 4 4 3 1 Domain of unknown function (DUF755) SpoIIIAH PF12685.7 CDI86115.1 - 0.017 15.0 27.9 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 SpoIIIAH-like protein MAP7 PF05672.11 CDI86115.1 - 0.079 12.6 26.6 0.13 12.0 26.6 1.3 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family FAM60A PF15396.6 CDI86115.1 - 0.086 12.8 23.4 0.33 10.9 13.9 2.4 2 0 0 2 2 2 0 Protein Family FAM60A Apc15p PF05841.11 CDI86115.1 - 0.31 11.8 32.4 5.8 7.7 0.1 2.4 2 0 0 2 2 2 0 Apc15p protein PNISR PF15996.5 CDI86115.1 - 0.52 10.6 35.9 0.17 12.1 28.0 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR SPX PF03105.19 CDI86115.1 - 1.3 8.8 38.2 0.69 9.8 24.5 2.0 2 0 0 2 2 2 0 SPX domain Plasmodium_Vir PF05795.11 CDI86115.1 - 1.6 8.1 18.5 1.8 7.9 11.6 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein CDC45 PF02724.14 CDI86115.1 - 4.3 5.5 23.2 18 3.5 22.2 1.9 2 0 0 2 2 2 0 CDC45-like protein FAM76 PF16046.5 CDI86115.1 - 5.2 6.3 33.1 2.1 7.6 25.1 2.1 2 0 0 2 2 2 0 FAM76 protein ALMT PF11744.8 CDI86115.1 - 7.5 5.3 22.7 3.2 6.5 16.8 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter FAM199X PF15814.5 CDI86115.1 - 8.2 5.4 47.6 0.016 14.3 16.0 2.2 2 0 0 2 2 2 0 Protein family FAM199X NAM-associated PF14303.6 CDI86115.1 - 9.1 7.0 42.7 43 4.8 21.7 2.4 1 1 1 2 2 2 0 No apical meristem-associated C-terminal domain DUF2052 PF09747.9 CDI86115.1 - 9.4 6.3 22.4 2.5 8.2 18.3 1.9 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Pkinase PF00069.25 CDI86117.1 - 1.3e-11 44.4 0.0 4.9e-07 29.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Apt1 PF10351.9 CDI86117.1 - 0.12 11.2 9.6 0.14 11.0 9.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Pkinase_Tyr PF07714.17 CDI86117.1 - 0.17 11.1 0.0 0.66 9.2 0.0 1.8 2 0 0 2 2 2 0 Protein tyrosine kinase Dmrt1 PF12374.8 CDI86117.1 - 1.4 9.4 24.8 0.39 11.2 3.5 2.5 2 0 0 2 2 2 0 Double-sex mab3 related transcription factor 1 DUF1117 PF06547.12 CDI86117.1 - 1.9 9.1 9.9 0.8 10.3 2.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) RskA PF10099.9 CDI86120.1 - 0.0067 16.8 8.4 0.0067 16.8 8.4 14.5 2 2 9 11 11 11 3 Anti-sigma-K factor rskA DNA_ligase_A_M PF01068.21 CDI86122.1 - 0.0044 16.7 1.0 0.0063 16.2 1.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain RskA PF10099.9 CDI86122.1 - 0.0047 17.2 36.1 0.0093 16.3 36.1 1.5 1 1 0 1 1 1 1 Anti-sigma-K factor rskA TraT PF05818.12 CDI86122.1 - 0.0084 15.8 16.7 0.011 15.4 16.7 1.1 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein Tic110 PF16940.5 CDI86122.1 - 0.031 12.8 13.8 0.034 12.6 13.8 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter Suf PF05843.14 CDI86122.1 - 0.046 13.7 12.9 0.048 13.6 12.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2232 PF09991.9 CDI86122.1 - 0.08 12.1 8.4 0.083 12.1 8.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) P5-ATPase PF12409.8 CDI86122.1 - 0.13 12.4 4.2 0.16 12.1 4.2 1.1 1 0 0 1 1 1 0 P5-type ATPase cation transporter TMEM247 PF15444.6 CDI86122.1 - 0.13 12.3 8.8 0.16 12.0 8.8 1.1 1 0 0 1 1 1 0 Transmembrane protein 247 SprA-related PF12118.8 CDI86122.1 - 0.17 11.0 30.3 0.2 10.7 30.3 1.0 1 0 0 1 1 1 0 SprA-related family eIF-3_zeta PF05091.12 CDI86122.1 - 0.17 10.8 13.4 0.19 10.7 13.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM60A PF15396.6 CDI86122.1 - 0.23 11.4 4.3 0.24 11.4 4.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A TFIIA PF03153.13 CDI86122.1 - 0.25 11.3 37.7 0.26 11.2 37.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EOS1 PF12326.8 CDI86122.1 - 0.34 10.8 2.5 0.39 10.6 2.5 1.2 1 0 0 1 1 1 0 N-glycosylation protein EIF4E-T PF10477.9 CDI86122.1 - 0.36 9.6 14.9 0.35 9.6 14.9 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF3506 PF12014.8 CDI86122.1 - 0.38 10.8 4.6 0.62 10.1 4.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3506) SpoIIP PF07454.11 CDI86122.1 - 0.4 10.1 8.8 0.49 9.8 8.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Spt20 PF12090.8 CDI86122.1 - 0.49 10.0 36.0 0.66 9.5 36.0 1.2 1 0 0 1 1 1 0 Spt20 family PigN PF04987.14 CDI86122.1 - 0.49 9.2 4.4 0.44 9.3 4.4 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Neur_chan_memb PF02932.16 CDI86122.1 - 0.53 10.3 5.0 0.54 10.3 5.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region THOC2_N PF16134.5 CDI86122.1 - 0.89 8.1 12.6 1 7.9 12.6 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Serinc PF03348.15 CDI86122.1 - 1 8.2 6.9 0.99 8.3 6.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) MMR1 PF08505.10 CDI86122.1 - 1.3 9.3 13.7 1.4 9.1 13.7 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DDHD PF02862.17 CDI86122.1 - 1.4 9.0 10.2 1.8 8.6 10.2 1.2 1 0 0 1 1 1 0 DDHD domain LMBR1 PF04791.16 CDI86122.1 - 1.8 7.3 4.6 1.7 7.5 4.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Peptidase_S15 PF02129.18 CDI86122.1 - 2.7 7.5 13.8 3.3 7.2 13.8 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) AAA_23 PF13476.6 CDI86122.1 - 3.4 8.1 16.3 3.7 8.0 16.3 1.1 1 0 0 1 1 1 0 AAA domain FAM199X PF15814.5 CDI86122.1 - 4.1 6.4 15.2 5.9 5.8 15.2 1.3 1 0 0 1 1 1 0 Protein family FAM199X Presenilin PF01080.17 CDI86122.1 - 6.2 5.5 15.1 7.4 5.2 15.1 1.1 1 0 0 1 1 1 0 Presenilin AMP-binding PF00501.28 CDI86122.1 - 6.3 5.3 8.9 6.5 5.2 8.9 1.0 1 0 0 1 1 1 0 AMP-binding enzyme Orf78 PF06024.12 CDI86122.1 - 7.1 7.0 11.0 4.9 7.5 9.0 1.7 1 1 1 2 2 2 0 Orf78 (ac78) Ipi1_N PF12333.8 CDI86122.1 - 7.4 7.2 12.3 15 6.3 12.3 1.7 1 1 0 1 1 1 0 Rix1 complex component involved in 60S ribosome maturation DcuA_DcuB PF03605.14 CDI86122.1 - 8.1 5.2 14.0 9.3 5.0 14.0 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF2722 PF10846.8 CDI86123.1 - 0.001 18.1 6.7 0.001 18.1 6.7 8.3 7 2 1 8 8 8 4 Protein of unknown function (DUF2722) RICTOR_M PF14666.6 CDI86123.1 - 0.015 15.0 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, middle domain Sacchrp_dh_C PF16653.5 CDI86123.1 - 1.1 9.4 15.1 0.55 10.3 0.2 3.7 4 0 0 4 4 4 0 Saccharopine dehydrogenase C-terminal domain RICTOR_N PF14664.6 CDI86124.1 - 0.0032 16.5 0.2 0.0032 16.5 0.2 6.9 9 2 1 10 10 10 3 Rapamycin-insensitive companion of mTOR, N-term SUIM_assoc PF16619.5 CDI86124.1 - 0.011 15.8 5.9 0.011 15.8 5.9 13.1 8 2 1 9 9 9 0 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI86124.1 - 0.97 9.7 0.0 0.97 9.7 0.0 9.8 2 2 3 7 7 7 0 Anti-sigma-K factor rskA HemX PF04375.14 CDI86125.1 - 0.025 13.9 48.2 0.03 13.6 48.2 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase OmpH PF03938.14 CDI86125.1 - 0.034 14.5 46.0 0.042 14.2 46.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) FAM60A PF15396.6 CDI86125.1 - 0.048 13.7 15.2 0.054 13.5 15.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A FapA PF03961.13 CDI86125.1 - 0.073 11.7 13.3 0.084 11.5 13.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A CobT PF06213.12 CDI86125.1 - 0.077 12.4 26.2 0.095 12.1 26.2 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Peptidase_S49_N PF08496.10 CDI86125.1 - 0.12 12.5 17.1 0.14 12.2 17.1 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF2828 PF11443.8 CDI86125.1 - 0.16 10.0 18.8 0.17 9.9 18.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) eIF-3_zeta PF05091.12 CDI86125.1 - 0.23 10.4 26.9 0.25 10.3 26.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Exonuc_VII_L PF02601.15 CDI86125.1 - 0.26 10.8 28.8 0.31 10.6 28.8 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Methyltransf_32 PF13679.6 CDI86125.1 - 0.29 11.1 19.0 0.37 10.8 19.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain VIR_N PF15912.5 CDI86125.1 - 0.34 10.5 8.8 0.35 10.4 8.8 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DUF572 PF04502.13 CDI86125.1 - 0.35 10.4 18.4 0.36 10.4 18.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) EIF4E-T PF10477.9 CDI86125.1 - 0.37 9.6 31.5 0.43 9.4 31.5 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E FTCD_C PF04961.12 CDI86125.1 - 0.48 10.2 9.4 0.82 9.4 9.4 1.3 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Presenilin PF01080.17 CDI86125.1 - 0.56 8.9 28.2 0.61 8.8 28.2 1.1 1 0 0 1 1 1 0 Presenilin DUF1387 PF07139.11 CDI86125.1 - 0.69 9.6 22.7 0.72 9.5 22.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) RR_TM4-6 PF06459.12 CDI86125.1 - 0.7 9.7 22.5 0.72 9.6 22.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 CDI86125.1 - 0.74 9.9 20.8 0.89 9.7 20.8 1.2 1 0 0 1 1 1 0 DDHD domain Peptidase_S15 PF02129.18 CDI86125.1 - 0.79 9.3 19.6 0.88 9.1 19.6 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) BORG_CEP PF14957.6 CDI86125.1 - 0.85 10.8 15.8 1 10.6 15.8 1.1 1 0 0 1 1 1 0 Cdc42 effector Endostatin PF06482.11 CDI86125.1 - 0.85 9.0 21.3 0.9 8.9 21.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin TFIIA PF03153.13 CDI86125.1 - 0.85 9.5 57.2 1.3 8.9 57.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sporozoite_P67 PF05642.11 CDI86125.1 - 0.89 7.6 8.1 1 7.4 8.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MMR1 PF08505.10 CDI86125.1 - 0.9 9.8 26.9 1.2 9.4 26.9 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein CCSAP PF15748.5 CDI86125.1 - 0.94 9.6 25.7 1.1 9.4 25.7 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SelP_N PF04592.14 CDI86125.1 - 1 8.7 27.9 1.2 8.4 27.9 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SLC12 PF03522.15 CDI86125.1 - 1.1 8.2 23.5 1.2 8.0 23.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 TCP PF03634.13 CDI86125.1 - 1.2 9.6 23.8 1.7 9.2 23.8 1.1 1 0 0 1 1 1 0 TCP family transcription factor YABBY PF04690.13 CDI86125.1 - 1.4 9.5 18.1 1.7 9.2 18.1 1.2 1 0 0 1 1 1 0 YABBY protein Serinc PF03348.15 CDI86125.1 - 1.4 7.8 13.4 1.5 7.6 13.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) CDC45 PF02724.14 CDI86125.1 - 1.5 7.1 18.9 1.6 6.9 18.9 1.0 1 0 0 1 1 1 0 CDC45-like protein SART-1 PF03343.13 CDI86125.1 - 1.6 7.2 25.9 1.7 7.1 25.9 1.0 1 0 0 1 1 1 0 SART-1 family SID-1_RNA_chan PF13965.6 CDI86125.1 - 1.7 7.0 10.1 1.9 6.8 10.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SpoIIP PF07454.11 CDI86125.1 - 1.9 7.9 21.8 2.6 7.4 21.8 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Macoilin PF09726.9 CDI86125.1 - 2.5 6.5 20.8 3.4 6.1 20.8 1.3 1 0 0 1 1 1 0 Macoilin family Connexin PF00029.19 CDI86125.1 - 2.6 7.8 16.0 3.6 7.3 16.0 1.3 1 0 0 1 1 1 0 Connexin FAM222A PF15258.6 CDI86125.1 - 2.8 6.9 39.4 3.4 6.6 39.4 1.2 1 0 0 1 1 1 0 Protein family of FAM222A HAUS6_N PF14661.6 CDI86125.1 - 3 7.4 24.6 3.4 7.2 24.6 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF913 PF06025.12 CDI86125.1 - 3.8 6.4 14.7 3.7 6.4 14.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2126 PF09899.9 CDI86125.1 - 4 5.4 16.5 4.5 5.2 16.5 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CLN3 PF02487.17 CDI86125.1 - 4 6.4 18.0 4.5 6.2 18.0 1.1 1 0 0 1 1 1 0 CLN3 protein Neur_chan_memb PF02932.16 CDI86125.1 - 4.1 7.4 19.2 4.6 7.2 19.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3332 PF11810.8 CDI86125.1 - 4.3 6.9 10.2 5.1 6.7 10.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) Velvet PF11754.8 CDI86125.1 - 4.5 7.1 23.2 5.9 6.7 23.2 1.3 1 0 0 1 1 1 0 Velvet factor Nop53 PF07767.11 CDI86125.1 - 5.1 6.4 29.7 5.5 6.3 29.7 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Cellulose_synt PF03552.14 CDI86125.1 - 5.5 5.4 10.2 5.6 5.3 10.2 1.0 1 0 0 1 1 1 0 Cellulose synthase Baculo_PP31 PF05311.11 CDI86125.1 - 5.7 6.3 18.7 7.7 5.9 18.7 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Zip PF02535.22 CDI86125.1 - 7.1 5.7 15.3 7.8 5.6 15.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Med19 PF10278.9 CDI86125.1 - 7.3 6.5 16.1 8.9 6.2 16.1 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Rtf2 PF04641.12 CDI86125.1 - 7.9 5.8 21.2 11 5.3 21.2 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger V_ATPase_I PF01496.19 CDI86125.1 - 8.2 4.2 27.6 9.1 4.1 27.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Band_3_cyto PF07565.13 CDI86125.1 - 8.3 6.1 22.3 13 5.5 22.3 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Lin-8 PF03353.15 CDI86125.1 - 8.9 5.8 29.6 9.5 5.7 29.6 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PAT1 PF09770.9 CDI86125.1 - 9.3 4.4 42.9 11 4.2 42.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4207 PF13904.6 CDI86126.1 - 0.0053 16.5 54.7 0.0053 16.5 54.7 8.2 6 2 2 8 8 8 2 Domain of unknown function (DUF4207) zf-C2HC5 PF06221.13 CDI86126.1 - 0.24 11.4 7.1 5.1 7.2 7.1 2.8 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type DUF4657 PF15552.6 CDI86127.1 - 0.41 10.2 10.1 0.051 13.1 5.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4657) RIFIN PF02009.16 CDI86127.1 - 8.8 6.1 6.3 12 5.6 6.3 1.3 1 0 0 1 1 1 0 Rifin SR-25 PF10500.9 CDI86128.1 - 0.00012 21.8 21.5 0.00012 21.8 21.5 4.5 3 1 1 4 4 4 2 Nuclear RNA-splicing-associated protein Tmemb_9 PF05434.11 CDI86129.1 - 0.0068 16.3 1.1 0.0095 15.8 1.1 1.2 1 0 0 1 1 1 1 TMEM9 DUF4808 PF16066.5 CDI86129.1 - 0.019 15.5 1.6 0.027 15.0 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4808) Baculo_11_kDa PF06143.11 CDI86129.1 - 0.043 13.4 1.5 0.056 13.0 1.5 1.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family WBP-1 PF11669.8 CDI86129.1 - 0.068 13.8 0.6 0.1 13.2 0.6 1.3 1 0 0 1 1 1 0 WW domain-binding protein 1 TFIIA PF03153.13 CDI86130.1 - 0.0038 17.3 73.2 0.0056 16.7 73.2 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SID-1_RNA_chan PF13965.6 CDI86130.1 - 0.0094 14.4 9.8 0.012 14.1 9.8 1.3 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 PTPRCAP PF15713.5 CDI86130.1 - 0.014 15.7 24.7 0.014 15.7 24.7 1.9 2 0 0 2 2 1 0 Protein tyrosine phosphatase receptor type C-associated O-antigen_lig PF13425.6 CDI86130.1 - 0.021 13.7 9.9 0.025 13.4 9.9 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SAPS PF04499.15 CDI86130.1 - 0.021 13.6 17.7 0.022 13.6 17.7 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein ALMT PF11744.8 CDI86130.1 - 0.041 12.7 21.6 0.045 12.6 21.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Apt1 PF10351.9 CDI86130.1 - 0.15 10.9 21.4 0.17 10.7 21.4 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain V_ATPase_I PF01496.19 CDI86130.1 - 0.21 9.5 24.3 0.26 9.2 24.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDK5_activator PF03261.15 CDI86130.1 - 0.26 10.8 26.0 0.28 10.7 26.0 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF2828 PF11443.8 CDI86130.1 - 0.4 8.7 22.0 0.59 8.1 22.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Raftlin PF15250.6 CDI86130.1 - 0.71 8.5 22.7 0.8 8.4 22.7 1.3 1 0 0 1 1 1 0 Raftlin Hid1 PF12722.7 CDI86130.1 - 0.73 7.9 31.1 0.83 7.7 31.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LMBR1 PF04791.16 CDI86130.1 - 0.74 8.7 12.1 0.73 8.7 12.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein CDC45 PF02724.14 CDI86130.1 - 0.79 7.9 26.4 1 7.6 26.4 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI86130.1 - 0.95 8.4 33.3 1.3 8.0 33.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 PA26 PF04636.13 CDI86130.1 - 0.99 8.2 22.2 1.2 8.0 22.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DDRGK PF09756.9 CDI86130.1 - 1 8.9 34.1 1.6 8.3 34.1 1.2 1 0 0 1 1 1 0 DDRGK domain TT_ORF1 PF02956.14 CDI86130.1 - 1.1 7.9 22.8 1.2 7.7 22.8 1.1 1 0 0 1 1 1 0 TT viral orf 1 VIR_N PF15912.5 CDI86130.1 - 1.2 8.7 15.3 1.5 8.4 15.3 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Spem1 PF15670.5 CDI86130.1 - 1.3 8.5 24.7 2 7.9 24.7 1.3 1 0 0 1 1 1 0 Spermatid maturation protein 1 PAT1 PF09770.9 CDI86130.1 - 1.8 6.7 54.4 2 6.6 54.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI86130.1 - 2 5.4 40.7 2.3 5.2 40.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAT1 PF06391.13 CDI86130.1 - 2.2 8.0 34.8 0.48 10.2 31.5 1.5 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Nucleoside_tran PF01733.18 CDI86130.1 - 2.8 7.2 11.8 5.1 6.4 11.8 1.5 1 1 0 1 1 1 0 Nucleoside transporter Hamartin PF04388.12 CDI86130.1 - 3.2 6.3 36.2 4.1 5.9 36.2 1.1 1 0 0 1 1 1 0 Hamartin protein Bud13 PF09736.9 CDI86130.1 - 3.3 8.1 31.9 0.85 10.0 28.4 1.7 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex FAM76 PF16046.5 CDI86130.1 - 3.5 6.9 31.3 5.5 6.3 31.3 1.4 1 0 0 1 1 1 0 FAM76 protein Nop53 PF07767.11 CDI86130.1 - 3.9 6.7 38.2 5.4 6.3 38.2 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Cellulose_synt PF03552.14 CDI86130.1 - 4.6 5.6 13.4 5.8 5.3 13.4 1.1 1 0 0 1 1 1 0 Cellulose synthase NPR3 PF03666.13 CDI86130.1 - 7.5 5.2 32.2 11 4.7 32.2 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Glyco_transf_41 PF13844.6 CDI86130.1 - 7.7 4.8 16.8 8.4 4.7 16.8 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 41 DUF4746 PF15928.5 CDI86130.1 - 8.4 5.7 22.0 13 5.0 22.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RRM_1 PF00076.22 CDI86133.1 - 1.1e-15 57.2 0.0 1.8e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOC PF07744.13 CDI86133.1 - 9.3e-11 41.9 0.0 4e-10 39.8 0.0 1.9 2 0 0 2 2 2 1 SPOC domain RRM_occluded PF16842.5 CDI86133.1 - 0.019 14.8 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif SET_assoc PF11767.8 CDI86133.1 - 0.044 13.4 0.2 0.075 12.7 0.2 1.3 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated TFIIA PF03153.13 CDI86133.1 - 2.9 7.8 44.2 7.7 6.4 37.4 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Methyltransf_11 PF08241.12 CDI86134.1 - 1.9e-12 47.6 0.1 1.8e-11 44.6 0.1 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDI86134.1 - 5.8e-10 39.8 0.3 6.1e-09 36.5 0.2 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI86134.1 - 5.3e-06 27.1 0.2 5.1e-05 23.9 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI86134.1 - 9.9e-06 25.4 0.3 2.2e-05 24.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI86134.1 - 0.00096 19.0 0.4 0.0028 17.5 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain DUF2722 PF10846.8 CDI86134.1 - 0.019 13.9 4.3 0.022 13.7 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) NNMT_PNMT_TEMT PF01234.17 CDI86134.1 - 0.063 12.5 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Connexin PF00029.19 CDI86134.1 - 0.28 10.9 2.1 0.46 10.2 2.1 1.3 1 0 0 1 1 1 0 Connexin Methyltransf_9 PF08003.11 CDI86134.1 - 0.3 10.0 1.9 0.34 9.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) Neur_chan_memb PF02932.16 CDI86134.1 - 1.2 9.2 3.3 1.9 8.5 3.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 CDI86134.1 - 2 6.6 5.5 2.6 6.2 5.5 1.1 1 0 0 1 1 1 0 CDC45-like protein UPF0560 PF10577.9 CDI86134.1 - 2.3 6.6 7.0 3 6.2 7.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 eIF-3_zeta PF05091.12 CDI86134.1 - 3.2 6.6 8.4 4.5 6.1 8.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI86134.1 - 4 6.1 5.8 5.5 5.6 5.8 1.1 1 0 0 1 1 1 0 Presenilin Rrn6 PF10214.9 CDI86134.1 - 4.3 5.7 13.6 5.9 5.3 13.6 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Peptidase_S49_N PF08496.10 CDI86134.1 - 4.3 7.4 8.0 8.2 6.5 8.0 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Rsc14 PF08586.10 CDI86134.1 - 9.1 7.2 6.8 1.1e+02 3.7 6.8 2.2 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit Radial_spoke_3 PF06098.11 CDI86134.1 - 9.4 5.4 17.0 15 4.7 17.0 1.2 1 0 0 1 1 1 0 Radial spoke protein 3 DUF3458_C PF17432.2 CDI86135.1 - 9.4e-100 334.1 7.7 1.5e-99 333.4 7.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 CDI86135.1 - 8.2e-44 149.8 0.8 1.5e-43 148.9 0.3 1.6 2 0 0 2 2 2 1 Peptidase family M1 domain zf-DNL PF05180.12 CDI86135.1 - 3.3e-27 94.2 0.5 6.3e-27 93.3 0.5 1.5 1 0 0 1 1 1 1 DNL zinc finger DUF3458 PF11940.8 CDI86135.1 - 3.2e-24 85.2 0.0 6.5e-24 84.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1_N PF17900.1 CDI86135.1 - 1.6e-10 41.5 0.0 3.7e-10 40.3 0.0 1.6 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DRMBL PF07522.14 CDI86135.1 - 0.0037 17.4 0.5 0.011 15.9 0.5 1.7 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase RMMBL PF07521.12 CDI86135.1 - 0.021 14.8 0.1 0.051 13.5 0.1 1.6 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain FSA_C PF10479.9 CDI86135.1 - 3.8 5.5 5.5 6.5 4.8 5.5 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus cNMP_binding PF00027.29 CDI86137.1 - 5.3e-13 48.9 0.0 5.4e-06 26.4 0.0 3.4 1 1 1 2 2 2 2 Cyclic nucleotide-binding domain ClpS PF02617.17 CDI86138.1 - 4.9e-13 48.7 0.2 4.9e-13 48.7 0.2 1.7 2 0 0 2 2 2 1 ATP-dependent Clp protease adaptor protein ClpS Cupin_1 PF00190.22 CDI86138.1 - 0.013 15.2 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 Cupin Pterin_bind PF00809.22 CDI86139.1 - 7.9e-76 255.0 0.0 1.1e-75 254.5 0.0 1.2 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 CDI86139.1 - 1.7e-24 86.5 0.0 4.7e-24 85.1 0.0 1.8 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) Shugoshin_N PF07558.11 CDI86139.1 - 1.5 8.7 5.2 0.22 11.4 0.5 2.2 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region tRNA-synt_1 PF00133.22 CDI86140.1 - 6.6e-08 31.3 0.0 9.2e-08 30.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) FUSC PF04632.12 CDI86140.1 - 0.00083 18.0 6.8 0.00095 17.8 6.8 1.1 1 0 0 1 1 1 1 Fusaric acid resistance protein family RSB_motif PF16294.5 CDI86141.1 - 0.019 15.2 12.8 0.019 15.2 12.8 4.9 4 1 1 5 5 5 0 RNSP1-SAP18 binding (RSB) motif CDC27 PF09507.10 CDI86142.1 - 6.8 6.0 7.9 7.4 5.8 7.9 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 MMR_HSR1 PF01926.23 CDI86143.1 - 2.7e-11 43.6 0.1 4.3e-11 42.9 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDI86143.1 - 2e-07 30.6 0.1 7.1e-06 25.6 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 CDI86143.1 - 0.0048 16.7 0.2 1.1 9.0 0.0 2.2 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 CDI86143.1 - 0.042 13.9 0.1 0.09 12.8 0.1 1.5 1 1 0 1 1 1 0 Dynamin family GTP_EFTU PF00009.27 CDI86143.1 - 0.14 11.7 0.1 0.97 8.9 0.1 2.1 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 CDI86143.1 - 0.19 11.9 2.5 0.6 10.3 2.5 1.8 1 1 0 1 1 1 0 AAA domain DUF3138 PF11336.8 CDI86143.1 - 0.68 8.5 7.7 0.88 8.1 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) RPN6_C_helix PF18503.1 CDI86144.1 - 0.0057 16.4 0.4 3.6 7.4 0.0 2.4 2 0 0 2 2 2 2 26S proteasome subunit RPN6 C-terminal helix domain ATG16 PF08614.11 CDI86144.1 - 0.028 14.6 1.3 0.042 14.1 1.3 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) SR-25 PF10500.9 CDI86144.1 - 3.3 7.3 13.9 1.3 8.6 10.4 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein FliT PF05400.13 CDI86145.1 - 0.1 13.4 0.1 18 6.2 0.1 2.4 2 0 0 2 2 2 0 Flagellar protein FliT TRM13 PF05206.14 CDI86145.1 - 0.21 11.1 0.8 8.7 5.8 0.1 2.1 2 0 0 2 2 2 0 Methyltransferase TRM13 SR-25 PF10500.9 CDI86146.1 - 6e-05 22.8 3.3 9.3e-05 22.1 3.3 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4366 PF14283.6 CDI86146.1 - 0.002 18.2 0.9 0.002 18.2 0.9 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF4366) GET2 PF08690.10 CDI86146.1 - 0.0039 16.9 5.4 0.0061 16.3 5.4 1.3 1 0 0 1 1 1 1 GET complex subunit GET2 Corona_nucleoca PF00937.18 CDI86146.1 - 0.04 13.0 9.5 0.054 12.5 9.5 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Activator_LAG-3 PF11498.8 CDI86146.1 - 0.043 12.8 24.8 0.062 12.3 24.8 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Roughex PF06020.11 CDI86146.1 - 0.058 12.5 2.2 0.073 12.2 2.2 1.3 1 0 0 1 1 1 0 Drosophila roughex protein MMR1 PF08505.10 CDI86146.1 - 0.076 13.3 9.6 0.094 13.0 9.6 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein PAT1 PF09770.9 CDI86146.1 - 0.08 11.2 12.9 0.083 11.2 12.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Spore_coat_CotO PF14153.6 CDI86146.1 - 0.081 12.8 8.5 0.16 11.9 8.5 1.5 1 0 0 1 1 1 0 Spore coat protein CotO SMYLE_N PF18615.1 CDI86146.1 - 0.082 12.5 7.7 0.097 12.2 7.7 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Presenilin PF01080.17 CDI86146.1 - 0.14 10.9 7.0 0.17 10.6 7.0 1.2 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 CDI86146.1 - 0.22 10.3 3.7 0.24 10.2 3.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SOBP PF15279.6 CDI86146.1 - 0.25 11.9 11.4 0.35 11.4 11.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein THOC2_N PF16134.5 CDI86146.1 - 0.58 8.7 6.7 1 7.9 6.7 1.4 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Suf PF05843.14 CDI86146.1 - 0.7 9.8 10.4 1.1 9.1 10.4 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 CDI86146.1 - 0.93 9.5 4.6 1.2 9.1 4.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GREB1 PF15782.5 CDI86146.1 - 1.6 5.8 13.3 1.7 5.6 13.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TCP PF03634.13 CDI86146.1 - 3.6 8.1 14.6 0.19 12.3 9.3 1.6 2 0 0 2 2 2 0 TCP family transcription factor Orf78 PF06024.12 CDI86146.1 - 4.3 7.7 6.1 2 8.7 3.0 1.9 1 1 1 2 2 2 0 Orf78 (ac78) Saw1 PF11561.8 CDI86146.1 - 4.9 6.6 7.5 7 6.1 7.5 1.1 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Sec16 PF12932.7 CDI86146.1 - 5.9 7.5 8.4 24 5.5 8.4 2.0 1 1 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region EIIBC-GUT_N PF03612.14 CDI86146.1 - 8.3 6.1 7.5 11 5.8 6.8 1.5 1 1 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TolA_bind_tri PF16331.5 CDI86148.1 - 0.00029 20.8 20.5 0.0013 18.8 3.1 3.9 4 0 0 4 4 4 2 TolA binding protein trimerisation SOGA PF11365.8 CDI86148.1 - 0.39 11.9 14.7 8.7 7.5 3.4 3.8 1 1 2 3 3 3 0 Protein SOGA CCM2_C PF16545.5 CDI86148.1 - 0.63 10.6 1.8 0.86 10.2 0.2 2.0 2 0 0 2 2 2 0 Cerebral cavernous malformation protein, harmonin-homology TSC22 PF01166.18 CDI86148.1 - 0.84 10.0 6.0 41 4.6 0.2 3.7 3 0 0 3 3 3 0 TSC-22/dip/bun family SlyX PF04102.12 CDI86148.1 - 1 10.0 29.7 0.12 13.0 4.7 5.2 4 2 1 5 5 5 0 SlyX FH2 PF02181.23 CDI86148.1 - 4.7 6.2 10.8 0.057 12.5 0.5 2.3 3 0 0 3 3 3 0 Formin Homology 2 Domain Myc_N PF01056.18 CDI86148.1 - 5 6.9 20.4 5.1 6.9 3.1 2.4 2 0 0 2 2 2 0 Myc amino-terminal region DivIC PF04977.15 CDI86148.1 - 5.3 6.9 25.7 4.6 7.1 3.7 4.5 3 1 1 4 4 4 0 Septum formation initiator DUF812 PF05667.11 CDI86150.1 - 1.7 7.4 25.9 1.8 7.3 25.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) HemX PF04375.14 CDI86150.1 - 2.6 7.2 6.7 2.8 7.2 6.7 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Spc7 PF08317.11 CDI86150.1 - 4.2 6.1 22.0 4.8 6.0 22.0 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Vfa1 PF08432.10 CDI86150.1 - 6.6 7.0 18.7 7.6 6.8 18.7 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 HAUS5 PF14817.6 CDI86150.1 - 6.9 5.3 13.2 7.4 5.2 13.2 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 TMPIT PF07851.13 CDI86150.1 - 7.9 5.6 8.0 7.7 5.7 8.0 1.0 1 0 0 1 1 1 0 TMPIT-like protein Lipoprotein_2 PF00921.17 CDI86151.1 - 0.0072 15.9 9.6 0.0075 15.9 9.6 1.0 1 0 0 1 1 1 1 Borrelia lipoprotein Glt_symporter PF03616.14 CDI86151.1 - 0.11 11.2 3.3 0.11 11.2 3.3 1.0 1 0 0 1 1 1 0 Sodium/glutamate symporter RskA PF10099.9 CDI86151.1 - 0.15 12.4 18.0 0.19 12.0 18.0 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA TMEM65 PF10507.9 CDI86151.1 - 0.54 10.2 3.8 0.59 10.1 3.8 1.1 1 0 0 1 1 1 0 Transmembrane protein 65 Ctr PF04145.15 CDI86151.1 - 0.56 10.8 2.3 0.6 10.7 2.3 1.0 1 0 0 1 1 1 0 Ctr copper transporter family TERB2 PF15101.6 CDI86151.1 - 0.9 9.6 16.3 0.89 9.6 16.3 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF1980 PF09323.10 CDI86151.1 - 1.4 8.8 7.5 1.5 8.7 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) LPP20 PF02169.16 CDI86151.1 - 1.9 8.9 17.2 2.2 8.7 17.2 1.2 1 0 0 1 1 1 0 LPP20 lipoprotein Med15 PF09606.10 CDI86151.1 - 3.4 6.2 32.5 3.4 6.2 32.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4834 PF16118.5 CDI86151.1 - 4.6 8.3 13.1 4.9 8.2 13.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Pex14_N PF04695.13 CDI86151.1 - 5.4 7.7 19.5 6.2 7.5 19.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 CDI86151.1 - 6.9 6.2 32.7 7.2 6.1 32.7 1.2 1 0 0 1 1 1 0 Spt20 family DUF2076 PF09849.9 CDI86152.1 - 3.8e-05 23.9 34.2 3.8e-05 23.9 34.2 2.6 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2076) ERM PF00769.19 CDI86152.1 - 1 9.2 47.3 0.7 9.7 20.4 2.4 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Apt1 PF10351.9 CDI86153.1 - 0.064 12.1 3.2 0.066 12.1 3.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Rrn6 PF10214.9 CDI86153.1 - 0.15 10.5 4.8 0.15 10.5 4.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor KIF1B PF12423.8 CDI86153.1 - 0.33 11.4 1.2 0.62 10.5 1.2 1.4 1 0 0 1 1 1 0 Kinesin protein 1B RIFIN PF02009.16 CDI86153.1 - 0.86 9.4 16.3 1.1 9.1 16.3 1.0 1 0 0 1 1 1 0 Rifin Shisa PF13908.6 CDI86153.1 - 2.2 8.5 21.1 1.7 8.9 8.1 2.1 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator 6PGD PF00393.19 CDI86153.1 - 3.2 7.1 13.3 4.1 6.7 13.3 1.3 1 0 0 1 1 1 0 6-phosphogluconate dehydrogenase, C-terminal domain DUF2477 PF10631.9 CDI86153.1 - 4.6 7.9 20.1 1.1 9.9 16.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2477) DUF755 PF05501.11 CDI86153.1 - 5.4 7.3 29.3 3 8.1 26.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF755) SR-25 PF10500.9 CDI86153.1 - 9.5 5.8 29.4 10 5.6 28.7 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4407 PF14362.6 CDI86154.1 - 0.027 13.8 25.6 0.038 13.3 25.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FAM176 PF14851.6 CDI86154.1 - 7.2 6.3 10.2 9.9 5.8 1.8 3.0 3 0 0 3 3 3 0 FAM176 family RIFIN PF02009.16 CDI86155.1 - 1.2 9.0 5.6 0.45 10.4 3.2 1.5 1 1 0 1 1 1 0 Rifin SUIM_assoc PF16619.5 CDI86155.1 - 3.4 7.8 31.0 0.21 11.7 7.2 3.2 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF1345 PF07077.11 CDI86155.1 - 7.8 6.2 10.8 1.4 8.5 3.5 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1345) IHABP4_N PF16174.5 CDI86156.1 - 0.016 15.9 9.5 0.016 15.9 9.5 2.1 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal CCSAP PF15748.5 CDI86156.1 - 0.081 13.1 27.3 0.063 13.5 14.7 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated AAA_11 PF13086.6 CDI86156.1 - 0.74 9.5 26.3 0.82 9.4 16.2 2.1 2 0 0 2 2 2 0 AAA domain Myc_N PF01056.18 CDI86156.1 - 1.2 8.9 18.4 0.28 11.1 7.0 2.1 2 0 0 2 2 2 0 Myc amino-terminal region MDM10 PF12519.8 CDI86156.1 - 3.4 6.4 17.0 0.1 11.4 7.4 2.0 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 DUF4471 PF14740.6 CDI86156.1 - 3.8 6.7 13.7 0.12 11.5 3.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) Spc7_N PF15402.6 CDI86156.1 - 3.9 5.6 23.6 0.17 10.1 15.1 2.0 2 0 0 2 2 2 0 N-terminus of kinetochore NMS complex subunit Spc7 MAT1 PF06391.13 CDI86156.1 - 6.3 6.6 30.5 1.1 9.1 15.1 2.4 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Presenilin PF01080.17 CDI86156.1 - 6.5 5.4 30.6 0.57 8.9 17.0 2.1 2 0 0 2 2 2 0 Presenilin ALMT PF11744.8 CDI86156.1 - 8.2 5.1 20.1 2.5 6.8 10.4 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter Med15 PF09606.10 CDI86157.1 - 0.00039 19.3 18.0 0.00039 19.3 18.0 4.4 4 1 0 4 4 4 2 ARC105 or Med15 subunit of Mediator complex non-fungal DUF966 PF06136.13 CDI86157.1 - 4.8 6.8 44.4 0.2 11.3 8.5 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF966) DUF1754 PF08555.10 CDI86160.1 - 5.8 7.8 37.7 5.6 7.8 27.5 2.1 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) SAGA-Tad1 PF12767.7 CDI86160.1 - 8.8 6.0 29.3 13 5.4 29.3 1.3 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit UPF0564 PF10595.9 CDI86161.1 - 0.15 11.1 34.4 0.17 10.9 34.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 AF-4 PF05110.13 CDI86161.1 - 1.1 7.3 38.1 1.5 6.8 38.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein RAP1 PF07218.11 CDI86161.1 - 3.8 5.7 15.3 4.3 5.5 15.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) LMBR1 PF04791.16 CDI86161.1 - 4.6 6.0 18.0 4.9 6.0 18.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 CDI86161.1 - 6 6.3 31.2 8.2 5.9 31.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_23 PF13476.6 CDI86161.1 - 6.2 7.3 29.3 8.4 6.8 29.3 1.2 1 0 0 1 1 1 0 AAA domain MRP-S27 PF10037.9 CDI86161.1 - 6.6 5.5 25.2 8.4 5.1 25.2 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 ALMT PF11744.8 CDI86161.1 - 6.6 5.4 21.3 8.2 5.1 21.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter PPP4R2 PF09184.11 CDI86161.1 - 7.6 6.0 21.3 9.4 5.7 21.3 1.1 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 CDI86162.1 - 0.003 15.9 28.2 0.0038 15.5 28.2 1.2 1 0 0 1 1 1 1 Nop14-like family LAP1C PF05609.12 CDI86162.1 - 0.0082 15.3 19.4 0.0099 15.0 19.4 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) Hid1 PF12722.7 CDI86162.1 - 0.11 10.6 15.1 0.14 10.2 15.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Borrelia_P83 PF05262.11 CDI86162.1 - 0.41 9.1 23.3 0.47 8.9 23.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Macoilin PF09726.9 CDI86162.1 - 3.3 6.2 17.1 3.5 6.1 17.1 1.1 1 0 0 1 1 1 0 Macoilin family Peptidase_S64 PF08192.11 CDI86162.1 - 4.4 5.7 16.7 5.1 5.4 16.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 Pex14_N PF04695.13 CDI86165.1 - 4.6 7.9 11.7 5.2 7.7 11.7 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Merozoite_SPAM PF07133.11 CDI86165.1 - 5 7.1 45.5 5.2 7.0 45.5 1.0 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CDC45 PF02724.14 CDI86165.1 - 7.4 4.7 35.5 7.7 4.7 35.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Coilin_N PF15862.5 CDI86165.1 - 7.4 6.4 20.2 8.4 6.2 20.2 1.1 1 0 0 1 1 1 0 Coilin N-terminus SpoIIIAH PF12685.7 CDI86168.1 - 1.1e-06 28.7 7.4 1.3e-06 28.4 7.4 1.0 1 0 0 1 1 1 1 SpoIIIAH-like protein V_ATPase_I PF01496.19 CDI86168.1 - 2.7e-05 22.3 25.8 3e-05 22.2 25.8 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI86168.1 - 4.2e-05 22.8 16.1 4.3e-05 22.7 16.1 1.0 1 0 0 1 1 1 1 CLN3 protein SARAF PF06682.12 CDI86168.1 - 4.6e-05 23.2 11.8 5.1e-05 23.1 11.8 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis SID-1_RNA_chan PF13965.6 CDI86168.1 - 7e-05 21.4 7.8 7.5e-05 21.3 7.8 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DUF4834 PF16118.5 CDI86168.1 - 0.00018 22.4 29.3 0.01 16.8 29.3 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4834) NicO PF03824.16 CDI86168.1 - 0.00019 20.9 12.2 0.00022 20.7 12.2 1.2 1 0 0 1 1 1 1 High-affinity nickel-transport protein TRAP_alpha PF03896.16 CDI86168.1 - 0.00033 20.0 8.0 0.00039 19.7 8.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Ctr PF04145.15 CDI86168.1 - 0.00099 19.7 11.0 0.0015 19.2 11.0 1.3 1 0 0 1 1 1 1 Ctr copper transporter family CBP_BcsG PF11658.8 CDI86168.1 - 0.001 17.5 14.7 0.0011 17.4 14.7 1.0 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG Serinc PF03348.15 CDI86168.1 - 0.0013 17.7 7.4 0.0015 17.5 7.4 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) SpoIIP PF07454.11 CDI86168.1 - 0.0014 18.2 14.6 0.0016 18.0 14.6 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) O-antigen_lig PF13425.6 CDI86168.1 - 0.0015 17.5 8.5 0.0015 17.4 8.5 1.0 1 0 0 1 1 1 1 O-antigen ligase like membrane protein MMM1 PF10296.9 CDI86168.1 - 0.0015 17.6 10.5 0.0018 17.4 10.5 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 LptF_LptG PF03739.14 CDI86168.1 - 0.0018 17.2 0.2 0.0023 16.8 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide export system permease LptF/LptG DUF913 PF06025.12 CDI86168.1 - 0.0035 16.4 5.5 0.0035 16.4 5.5 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Peptidase_S49_N PF08496.10 CDI86168.1 - 0.0046 17.0 17.8 0.0052 16.8 17.8 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal OAD_gamma PF04277.13 CDI86168.1 - 0.0048 17.5 0.2 0.015 15.8 0.2 1.9 1 1 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain Ni_hydr_CYTB PF01292.20 CDI86168.1 - 0.0054 16.3 0.6 0.0081 15.8 0.6 1.3 1 0 0 1 1 1 1 Prokaryotic cytochrome b561 DUF4446 PF14584.6 CDI86168.1 - 0.011 15.8 11.2 0.013 15.4 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) CSG2 PF16965.5 CDI86168.1 - 0.012 14.6 10.6 0.015 14.2 10.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator FAM176 PF14851.6 CDI86168.1 - 0.03 14.0 18.2 0.14 11.8 18.2 1.8 1 1 0 1 1 1 0 FAM176 family Choline_transpo PF04515.12 CDI86168.1 - 0.042 13.1 0.0 0.043 13.0 0.0 1.1 1 0 0 1 1 1 0 Plasma-membrane choline transporter SLC12 PF03522.15 CDI86168.1 - 0.083 11.9 22.5 0.087 11.8 22.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Scs3p PF10261.9 CDI86168.1 - 0.087 12.3 10.3 0.13 11.8 10.3 1.3 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Pex24p PF06398.11 CDI86168.1 - 0.094 11.7 5.9 0.22 10.5 5.9 1.6 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin CCDC53 PF10152.9 CDI86168.1 - 0.11 12.9 19.2 0.16 12.4 19.2 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF898 PF05987.13 CDI86168.1 - 0.14 11.2 0.4 0.2 10.7 0.1 1.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF898) DUF2448 PF10476.9 CDI86168.1 - 0.16 11.9 5.9 0.2 11.5 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) PIP5K PF01504.18 CDI86168.1 - 0.16 11.2 16.8 0.19 10.9 16.8 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase MFS_1_like PF12832.7 CDI86168.1 - 0.16 10.8 0.0 0.17 10.7 0.0 1.3 1 1 0 1 1 1 0 MFS_1 like family FliP PF00813.20 CDI86168.1 - 0.19 11.6 11.5 0.23 11.3 11.5 1.1 1 0 0 1 1 1 0 FliP family Tmp39 PF10271.9 CDI86168.1 - 0.22 10.5 11.3 0.24 10.4 11.3 1.0 1 0 0 1 1 1 0 Putative transmembrane protein CobT PF06213.12 CDI86168.1 - 0.24 10.8 30.6 0.29 10.5 30.6 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT HemX PF04375.14 CDI86168.1 - 0.25 10.6 49.6 0.28 10.4 49.6 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase AI-2E_transport PF01594.16 CDI86168.1 - 0.29 10.2 7.2 0.35 10.0 7.2 1.1 1 0 0 1 1 1 0 AI-2E family transporter Mem_trans PF03547.18 CDI86168.1 - 0.34 9.3 9.1 0.37 9.1 9.1 1.1 1 0 0 1 1 1 0 Membrane transport protein Tmemb_9 PF05434.11 CDI86168.1 - 0.38 10.6 26.0 0.72 9.7 26.0 1.4 1 1 0 1 1 1 0 TMEM9 DUF4330 PF14221.6 CDI86168.1 - 0.38 10.9 2.4 0.62 10.3 2.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4330) Virul_fac_BrkB PF03631.15 CDI86168.1 - 0.39 10.3 5.5 0.26 10.9 3.9 1.4 1 1 0 1 1 1 0 Virulence factor BrkB Connexin PF00029.19 CDI86168.1 - 0.41 10.4 23.4 0.69 9.6 23.4 1.5 1 1 0 1 1 1 0 Connexin HemY_N PF07219.13 CDI86168.1 - 0.43 10.8 11.6 1.3 9.3 11.6 1.9 1 1 0 1 1 1 0 HemY protein N-terminus FAM76 PF16046.5 CDI86168.1 - 0.47 9.8 27.7 0.56 9.5 27.7 1.1 1 0 0 1 1 1 0 FAM76 protein DUF2828 PF11443.8 CDI86168.1 - 0.54 8.3 26.0 0.63 8.1 26.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CRA PF06589.11 CDI86168.1 - 0.59 10.2 6.6 0.66 10.1 5.9 1.5 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) MSP1a PF11670.8 CDI86168.1 - 0.63 9.3 5.6 0.29 10.4 3.7 1.4 1 1 0 1 1 1 0 Major surface protein 1a (MSP1a) Acatn PF13000.7 CDI86168.1 - 0.65 8.4 5.1 0.82 8.1 5.1 1.3 1 1 0 1 1 1 0 Acetyl-coenzyme A transporter 1 HCO3_cotransp PF00955.21 CDI86168.1 - 0.78 8.5 9.2 0.92 8.3 9.2 1.2 1 0 0 1 1 1 0 HCO3- transporter family ABC2_membrane_2 PF12679.7 CDI86168.1 - 0.79 9.0 14.1 1.3 8.2 14.1 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF2254 PF10011.9 CDI86168.1 - 0.8 8.5 7.8 1.1 8.0 7.8 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) Velvet PF11754.8 CDI86168.1 - 0.91 9.4 21.7 1 9.2 21.7 1.1 1 0 0 1 1 1 0 Velvet factor G6B PF15096.6 CDI86168.1 - 0.94 9.2 5.4 1.1 8.9 5.4 1.1 1 0 0 1 1 1 0 G6B family YABBY PF04690.13 CDI86168.1 - 1 9.9 18.7 1.3 9.6 18.7 1.2 1 0 0 1 1 1 0 YABBY protein Ureide_permease PF07168.11 CDI86168.1 - 1 8.0 8.2 1.3 7.7 8.2 1.4 1 0 0 1 1 1 0 Ureide permease Sugar_tr PF00083.24 CDI86168.1 - 1.3 7.8 3.1 1.5 7.6 3.1 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter PepSY_TM_like_2 PF16357.5 CDI86168.1 - 1.5 8.7 15.6 1.8 8.5 15.6 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like K_trans PF02705.16 CDI86168.1 - 1.6 7.2 7.2 2 6.9 7.2 1.2 1 0 0 1 1 1 0 K+ potassium transporter NEMP PF10225.9 CDI86168.1 - 1.7 8.3 9.8 2.5 7.7 9.8 1.3 1 0 0 1 1 1 0 NEMP family Ac76 PF05814.11 CDI86168.1 - 1.8 8.6 7.7 3.2 7.8 7.7 1.7 1 1 0 1 1 1 0 Orf76 (Ac76) DUF2140 PF09911.9 CDI86168.1 - 1.8 8.1 20.4 0.39 10.2 16.3 1.7 1 1 1 2 2 1 0 Uncharacterized protein conserved in bacteria (DUF2140) Herpes_glycop PF01528.16 CDI86168.1 - 2.5 6.8 11.7 6.4 5.5 11.7 1.7 1 1 0 1 1 1 0 Herpesvirus glycoprotein M DUF3357 PF11837.8 CDI86168.1 - 2.5 8.6 11.5 15 6.1 11.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) Nucleoside_tran PF01733.18 CDI86168.1 - 2.8 7.3 9.9 3.8 6.8 9.9 1.3 1 1 0 1 1 1 0 Nucleoside transporter BORG_CEP PF14957.6 CDI86168.1 - 2.9 9.1 17.7 3.4 8.8 17.7 1.1 1 0 0 1 1 1 0 Cdc42 effector Folate_carrier PF01770.18 CDI86168.1 - 3 6.5 16.7 4.9 5.8 16.7 1.4 1 1 0 1 1 1 0 Reduced folate carrier GRP PF07172.11 CDI86168.1 - 3.3 8.5 17.8 20 6.0 17.8 2.1 1 1 0 1 1 1 0 Glycine rich protein family DUF443 PF04276.12 CDI86168.1 - 3.5 7.4 5.8 0.5 10.1 1.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF443) VanZ PF04892.12 CDI86168.1 - 3.8 8.2 6.2 11 6.6 6.1 2.0 1 1 0 1 1 1 0 VanZ like family DUF4131 PF13567.6 CDI86168.1 - 4.8 6.8 11.3 9.2 5.9 11.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) PepSY_TM PF03929.16 CDI86168.1 - 5.1 6.7 18.4 7.9 6.1 18.4 1.4 1 1 0 1 1 1 0 PepSY-associated TM region TssO PF17561.2 CDI86168.1 - 5.3 7.1 23.6 24 5.0 23.6 1.9 1 1 0 1 1 1 0 Type VI secretion system, TssO PMT_4TMC PF16192.5 CDI86168.1 - 5.6 6.5 9.0 11 5.5 8.9 1.8 1 1 0 1 1 1 0 C-terminal four TMM region of protein-O-mannosyltransferase DUF3742 PF12553.8 CDI86168.1 - 5.7 7.1 6.1 26 4.9 6.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3742) DUF3169 PF11368.8 CDI86168.1 - 5.7 6.4 9.3 13 5.2 9.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3169) DUF4569 PF15133.6 CDI86168.1 - 5.8 6.5 30.4 7.1 6.3 30.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Endonuc_Holl PF10107.9 CDI86168.1 - 6.7 6.5 19.3 9.3 6.1 19.3 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Plasmodium_Vir PF05795.11 CDI86168.1 - 6.8 6.0 13.9 7.1 5.9 13.9 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF2370 PF10176.9 CDI86168.1 - 7.6 6.1 16.4 9.3 5.8 16.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) MAP17 PF15807.5 CDI86168.1 - 8.2 6.7 22.8 16 5.7 22.8 1.5 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 EphA2_TM PF14575.6 CDI86168.1 - 8.2 7.4 31.2 1.8e+04 -3.4 31.2 2.8 1 1 0 1 1 0 0 Ephrin type-A receptor 2 transmembrane domain Comm PF15957.5 CDI86168.1 - 8.3 6.8 16.8 79 3.6 16.8 2.0 1 1 0 1 1 1 0 Commissureless SIT PF15330.6 CDI86168.1 - 8.9 6.8 29.4 14 6.2 29.4 1.4 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Tetraspanin PF00335.20 CDI86168.1 - 9.2 5.9 17.4 13 5.4 17.4 1.4 1 1 0 1 1 1 0 Tetraspanin family Ribosomal_L12_N PF16320.5 CDI86169.1 - 0.038 13.7 0.2 0.038 13.7 0.2 5.3 4 1 0 4 4 4 0 Ribosomal protein L7/L12 dimerisation domain CRT10 PF08728.10 CDI86171.1 - 0.13 10.5 3.2 0.14 10.3 3.2 1.1 1 0 0 1 1 1 0 CRT10 SR-25 PF10500.9 CDI86172.1 - 3.7e-05 23.5 14.8 5.4e-05 22.9 14.8 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein SOBP PF15279.6 CDI86172.1 - 0.041 14.5 14.0 0.048 14.3 14.0 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Presenilin PF01080.17 CDI86172.1 - 0.044 12.6 11.2 0.051 12.3 11.2 1.1 1 0 0 1 1 1 0 Presenilin DUF1501 PF07394.12 CDI86172.1 - 0.094 11.8 6.6 0.1 11.6 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) PAT1 PF09770.9 CDI86172.1 - 0.1 10.8 13.9 0.12 10.6 13.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 cwf18 PF08315.12 CDI86172.1 - 0.12 13.0 8.3 0.16 12.6 8.3 1.1 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor DUF719 PF05334.13 CDI86172.1 - 0.14 12.4 12.7 0.21 11.8 9.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF719) GREB1 PF15782.5 CDI86172.1 - 0.4 7.8 13.3 0.43 7.6 13.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_S49_N PF08496.10 CDI86172.1 - 0.52 10.4 5.8 0.79 9.8 5.8 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal V_ATPase_I PF01496.19 CDI86172.1 - 0.52 8.2 6.5 0.62 7.9 6.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Suf PF05843.14 CDI86172.1 - 0.79 9.6 14.3 0.96 9.4 14.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hydin_ADK PF17213.3 CDI86172.1 - 0.87 9.8 12.7 1.3 9.3 12.7 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Zip PF02535.22 CDI86172.1 - 0.97 8.6 6.3 1.1 8.3 6.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Serinc PF03348.15 CDI86172.1 - 2.3 7.1 8.6 2.7 6.8 8.6 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Cellulose_synt PF03552.14 CDI86172.1 - 2.3 6.6 4.8 2.6 6.4 4.8 1.0 1 0 0 1 1 1 0 Cellulose synthase LMBR1 PF04791.16 CDI86172.1 - 4 6.2 9.3 4.8 6.0 9.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein ATG22 PF11700.8 CDI86174.1 - 3.3e-05 22.7 1.4 3.5e-05 22.6 1.4 1.1 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like ThrE PF06738.12 CDI86174.1 - 0.00033 20.1 1.7 0.00048 19.6 1.7 1.2 1 0 0 1 1 1 1 Putative threonine/serine exporter DUF2722 PF10846.8 CDI86174.1 - 0.001 18.1 7.6 0.001 18.1 7.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TAF4 PF05236.14 CDI86174.1 - 0.11 12.3 7.9 0.15 11.8 7.9 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Peptidase_C58 PF03543.14 CDI86174.1 - 0.16 11.6 10.8 0.22 11.2 10.8 1.2 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen DUF2009 PF09418.10 CDI86174.1 - 0.18 10.9 3.1 0.19 10.8 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) Tho2 PF11262.8 CDI86174.1 - 0.24 10.5 4.1 0.26 10.4 4.1 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 p53-inducible11 PF14936.6 CDI86174.1 - 0.42 10.6 2.8 0.51 10.4 2.8 1.1 1 0 0 1 1 1 0 Tumour protein p53-inducible protein 11 Suf PF05843.14 CDI86174.1 - 0.76 9.7 6.3 0.87 9.5 6.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) ATP-synt_E PF05680.12 CDI86174.1 - 1.8 9.0 9.9 4.7 7.6 9.9 1.7 1 0 0 1 1 1 0 ATP synthase E chain Orf78 PF06024.12 CDI86174.1 - 4.1 7.8 6.0 2.7 8.3 2.2 2.1 2 1 0 2 2 2 0 Orf78 (ac78) TERB2 PF15101.6 CDI86174.1 - 4.2 7.4 11.6 5 7.1 11.6 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Roughex PF06020.11 CDI86174.1 - 5.8 5.9 12.4 7.7 5.5 12.4 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Orf78 PF06024.12 CDI86175.1 - 0.019 15.2 0.2 0.019 15.2 0.2 2.8 3 0 0 3 3 3 0 Orf78 (ac78) Secretin_N_2 PF07655.13 CDI86175.1 - 0.044 14.3 54.8 0.49 11.0 12.8 3.9 4 0 0 4 4 4 0 Secretin N-terminal domain AUX_IAA PF02309.16 CDI86175.1 - 1.2 9.0 10.9 5.3 6.8 10.9 1.9 1 1 0 1 1 1 0 AUX/IAA family Utp14 PF04615.13 CDI86175.1 - 3 6.3 8.9 4.3 5.8 8.9 1.3 1 0 0 1 1 1 0 Utp14 protein NINJA_B PF16136.5 CDI86176.1 - 1.2 9.5 10.5 0.76 10.2 1.8 2.6 3 0 0 3 3 3 0 Putative nuclear localisation signal DUF4834 PF16118.5 CDI86177.1 - 0.00083 20.3 6.7 0.0011 19.9 6.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) DUF4381 PF14316.6 CDI86177.1 - 0.008 16.4 2.2 0.0098 16.1 2.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) Med15 PF09606.10 CDI86177.1 - 0.015 14.0 16.0 0.014 14.1 16.0 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ctr PF04145.15 CDI86177.1 - 0.016 15.8 1.3 0.018 15.7 1.3 1.0 1 0 0 1 1 1 0 Ctr copper transporter family DUF4446 PF14584.6 CDI86177.1 - 0.018 15.0 0.6 0.022 14.8 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Spt20 PF12090.8 CDI86177.1 - 0.02 14.5 18.5 0.02 14.5 18.5 1.0 1 0 0 1 1 1 0 Spt20 family Cyclin_C PF02984.19 CDI86177.1 - 0.08 13.0 3.7 0.13 12.3 3.6 1.5 1 1 0 1 1 1 0 Cyclin, C-terminal domain Peptidase_S15 PF02129.18 CDI86177.1 - 0.12 12.0 7.2 0.12 11.9 7.2 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF1980 PF09323.10 CDI86177.1 - 0.15 12.0 1.1 0.16 11.9 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) SID-1_RNA_chan PF13965.6 CDI86177.1 - 0.17 10.3 0.4 0.17 10.3 0.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 R_equi_Vir PF05526.11 CDI86177.1 - 0.19 11.6 5.8 0.21 11.4 5.8 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF2232 PF09991.9 CDI86177.1 - 0.21 10.8 1.5 0.28 10.3 1.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) TFIIA PF03153.13 CDI86177.1 - 0.27 11.2 17.7 0.26 11.2 17.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI86177.1 - 0.29 11.4 20.5 0.87 9.9 20.5 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Med3 PF11593.8 CDI86177.1 - 0.37 9.9 20.3 0.5 9.5 20.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Serinc PF03348.15 CDI86177.1 - 0.69 8.8 2.8 0.67 8.8 2.8 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4148 PF13663.6 CDI86177.1 - 0.99 9.6 8.9 2.4 8.4 8.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4148) Presenilin PF01080.17 CDI86177.1 - 1.1 8.0 5.9 1.1 8.0 5.9 1.2 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 CDI86177.1 - 1.1 8.1 11.8 1.1 8.2 11.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4179 PF13786.6 CDI86177.1 - 1.2 9.7 7.9 1.6 9.3 7.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) DUF2722 PF10846.8 CDI86177.1 - 4.5 6.1 20.0 5.6 5.8 20.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) WD40 PF00400.32 CDI86179.1 - 0.00051 20.8 0.5 1.2 10.1 0.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Suf PF05843.14 CDI86179.1 - 0.011 15.8 21.3 0.021 14.8 21.3 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) IHABP4_N PF16174.5 CDI86179.1 - 0.016 15.8 1.3 0.016 15.8 1.3 4.1 4 1 1 5 5 2 0 Intracellular hyaluronan-binding protein 4 N-terminal AbLIM_anchor PF16182.5 CDI86179.1 - 0.24 11.2 14.0 0.37 10.6 14.0 1.3 1 0 0 1 1 1 0 Putative adherens-junction anchoring region of AbLIM SLC12 PF03522.15 CDI86179.1 - 1.1 8.1 18.6 1.8 7.5 18.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Sin_N PF04801.13 CDI86179.1 - 2.5 7.2 34.7 5.5 6.1 34.7 1.5 1 0 0 1 1 1 0 Sin-like protein conserved region CSG2 PF16965.5 CDI86179.1 - 2.7 6.8 14.3 0.84 8.5 10.9 1.8 2 0 0 2 2 2 0 Ceramide synthase regulator AAA_23 PF13476.6 CDI86179.1 - 6.6 7.2 23.3 13 6.2 23.3 1.4 1 0 0 1 1 1 0 AAA domain Hid1 PF12722.7 CDI86179.1 - 7.7 4.5 20.9 12 3.9 20.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Dicty_REP PF05086.12 CDI86179.1 - 7.8 4.3 7.0 12 3.7 7.0 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Peptidase_S64 PF08192.11 CDI86179.1 - 8.8 4.7 17.7 13 4.1 17.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 RskA PF10099.9 CDI86180.1 - 1.3e-05 25.6 25.9 0.00045 20.5 9.1 2.1 1 1 1 2 2 2 2 Anti-sigma-K factor rskA SARAF PF06682.12 CDI86180.1 - 0.0005 19.8 14.7 0.00064 19.5 14.7 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis DUF4834 PF16118.5 CDI86180.1 - 0.031 15.3 5.0 0.031 15.3 5.0 3.1 2 1 0 2 2 1 0 Domain of unknown function (DUF4834) DUF4647 PF15504.6 CDI86180.1 - 0.072 12.2 19.2 0.097 11.8 19.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) MRP-S31 PF15433.6 CDI86180.1 - 0.077 12.6 16.7 0.1 12.3 16.7 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 SPX PF03105.19 CDI86180.1 - 0.097 12.6 16.8 0.11 12.3 16.8 1.1 1 0 0 1 1 1 0 SPX domain GT87 PF09594.10 CDI86180.1 - 0.15 11.8 4.3 0.39 10.4 4.3 1.5 1 1 0 1 1 1 0 Glycosyltransferase family 87 PA26 PF04636.13 CDI86180.1 - 0.53 9.2 12.4 0.62 8.9 12.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PAT1 PF09770.9 CDI86180.1 - 0.68 8.1 32.3 0.78 7.9 32.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MPM1 PF17234.2 CDI86180.1 - 0.83 9.9 23.8 1.5 9.0 7.0 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 MRP-S26 PF14943.6 CDI86180.1 - 1.3 8.9 15.0 2.3 8.1 15.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 ATAD4 PF15321.6 CDI86180.1 - 1.7 10.0 14.3 0.8 11.1 1.0 2.4 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 V_ATPase_I PF01496.19 CDI86180.1 - 2.4 5.9 17.5 0.15 9.9 3.2 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF4386 PF14329.6 CDI86180.1 - 2.5 7.9 11.3 3.2 7.6 4.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4386) UPF0524 PF15823.5 CDI86180.1 - 4.3 6.7 17.0 0.36 10.2 3.5 2.1 2 0 0 2 2 2 0 UPF0524 of C3orf70 GREB1 PF15782.5 CDI86180.1 - 4.8 4.2 26.7 5.9 3.9 26.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MLANA PF14991.6 CDI86180.1 - 5.2 7.4 9.5 0.13 12.5 1.6 2.2 1 1 2 3 3 3 0 Protein melan-A DUF4366 PF14283.6 CDI86180.1 - 6.1 6.9 16.8 0.59 10.2 4.4 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) Nse4_C PF08743.10 CDI86180.1 - 6.2 7.2 12.1 12 6.2 1.3 2.6 2 0 0 2 2 2 0 Nse4 C-terminal Med15 PF09606.10 CDI86180.1 - 6.4 5.3 45.4 9.6 4.7 45.4 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Dehydrin PF00257.19 CDI86181.1 - 0.0071 16.9 3.9 0.0071 16.9 3.9 10.9 6 4 1 7 7 7 2 Dehydrin Spt20 PF12090.8 CDI86182.1 - 0.00041 20.0 16.7 0.00063 19.4 16.7 1.3 1 0 0 1 1 1 1 Spt20 family DUF3452 PF11934.8 CDI86182.1 - 0.045 13.3 0.2 0.067 12.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) NDUFA12 PF05071.16 CDI86182.1 - 0.091 13.6 1.5 0.15 12.9 1.5 1.3 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase subunit NDUFA12 Lin-8 PF03353.15 CDI86182.1 - 0.29 10.6 5.7 0.3 10.6 5.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SOG2 PF10428.9 CDI86182.1 - 2.7 7.1 23.5 4 6.5 23.5 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein NST1 PF13945.6 CDI86182.1 - 3.4 7.7 11.7 3.2 7.8 10.8 1.4 1 1 0 1 1 1 0 Salt tolerance down-regulator Presenilin PF01080.17 CDI86182.1 - 4.5 5.9 9.8 6.2 5.5 9.8 1.2 1 0 0 1 1 1 0 Presenilin RIFIN PF02009.16 CDI86182.1 - 8.3 6.2 18.3 13 5.6 18.3 1.2 1 0 0 1 1 1 0 Rifin SUIM_assoc PF16619.5 CDI86183.1 - 0.82 9.8 23.5 0.079 13.0 5.0 2.8 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Med15 PF09606.10 CDI86183.1 - 4.2 5.9 28.9 5.5 5.6 28.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RskA PF10099.9 CDI86183.1 - 5.1 7.3 56.8 2.6 8.3 27.8 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Cwf_Cwc_15 PF04889.12 CDI86184.1 - 0.0021 17.8 36.6 0.0025 17.6 36.6 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein SR-25 PF10500.9 CDI86184.1 - 0.064 12.9 46.5 0.13 11.8 45.8 1.7 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein BAF1_ABF1 PF04684.13 CDI86184.1 - 2.2 7.2 40.1 2.8 6.9 40.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4207 PF13904.6 CDI86184.1 - 2.4 7.8 68.7 4.3 7.0 68.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) RskA PF10099.9 CDI86184.1 - 3.3 8.0 39.2 0.37 11.1 7.8 3.0 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF4205 PF13898.6 CDI86185.1 - 0.0099 14.8 3.8 0.015 14.2 3.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) Spt20 PF12090.8 CDI86185.1 - 0.015 14.9 11.7 0.023 14.3 11.7 1.4 1 0 0 1 1 1 0 Spt20 family Peptidase_S64 PF08192.11 CDI86185.1 - 0.13 10.8 7.8 0.19 10.1 7.8 1.3 1 0 0 1 1 1 0 Peptidase family S64 DUF4834 PF16118.5 CDI86185.1 - 0.2 12.6 2.2 0.54 11.2 2.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Activator_LAG-3 PF11498.8 CDI86185.1 - 0.49 9.3 19.4 1 8.3 19.4 1.5 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Hydrolase_4 PF12146.8 CDI86185.1 - 3.3 6.9 8.2 11 5.2 1.6 3.2 3 1 0 3 3 3 0 Serine aminopeptidase, S33 Spt20 PF12090.8 CDI86186.1 - 0.00069 19.3 20.0 0.00069 19.3 20.0 16.6 8 5 3 12 12 12 3 Spt20 family RskA PF10099.9 CDI86186.1 - 0.0017 18.7 12.8 0.0017 18.7 12.8 15.9 3 3 7 10 10 10 3 Anti-sigma-K factor rskA UPF0564 PF10595.9 CDI86186.1 - 0.0035 16.5 10.8 0.0035 16.5 10.8 9.3 8 2 0 8 8 8 1 Uncharacterised protein family UPF0564 Glyco_hydro_9 PF00759.19 CDI86186.1 - 0.0036 16.8 2.1 0.0036 16.8 2.1 8.6 2 2 1 5 5 5 1 Glycosyl hydrolase family 9 AF-4 PF05110.13 CDI86187.1 - 3.6 5.5 71.9 5.1 5.1 71.9 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein BUD22 PF09073.10 CDI86188.1 - 4.7 6.4 52.8 5.1 6.3 52.8 1.0 1 0 0 1 1 1 0 BUD22 Metallophos PF00149.28 CDI86190.1 - 1.5e-06 28.9 0.0 4.2e-06 27.4 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase ABC_tran PF00005.27 CDI86191.1 - 1.4e-22 80.7 0.0 2e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 CDI86191.1 - 2.3e-21 76.2 18.7 3.8e-21 75.5 18.7 1.3 1 0 0 1 1 1 1 ABC-2 type transporter AAA_25 PF13481.6 CDI86191.1 - 4e-05 23.3 1.0 0.042 13.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.7 CDI86191.1 - 5.9e-05 22.3 13.8 5.9e-05 22.3 13.8 1.8 2 0 0 2 2 2 1 ABC-2 family transporter protein AAA_16 PF13191.6 CDI86191.1 - 0.005 17.2 0.0 0.0088 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CDI86191.1 - 0.0063 16.4 0.0 0.079 12.8 0.0 2.1 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 CDI86191.1 - 0.011 15.6 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 CDI86191.1 - 0.016 15.1 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 CDI86191.1 - 0.016 15.7 0.0 0.026 15.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDI86191.1 - 0.046 14.0 0.0 0.16 12.3 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDI86191.1 - 0.057 13.7 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDI86191.1 - 0.11 12.3 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDI86191.1 - 0.11 12.2 0.4 0.26 11.0 0.1 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CDI86191.1 - 0.17 12.4 0.0 0.26 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDI86191.1 - 0.18 12.2 0.0 0.32 11.4 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Helicase_C PF00271.31 CDI86192.1 - 2.8e-10 40.5 0.0 2e-08 34.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDI86192.1 - 1.2e-07 31.7 0.0 0.00011 22.0 0.0 2.6 3 0 0 3 3 3 2 DEAD/DEAH box helicase HHH_5 PF14520.6 CDI86192.1 - 0.061 13.9 0.0 0.16 12.6 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain DUF974 PF06159.13 CDI86193.1 - 2.3e-07 30.9 2.0 0.00085 19.2 0.1 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF974) Trs65 PF12735.7 CDI86193.1 - 2.2e-06 27.3 0.1 0.038 13.4 0.2 2.1 2 0 0 2 2 2 2 TRAPP trafficking subunit Trs65 Transglut_C PF00927.22 CDI86193.1 - 0.13 12.4 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain Peptidase_M16 PF00675.20 CDI86194.1 - 3.3e-43 147.2 1.8 7.8e-43 146.0 0.1 2.5 2 1 1 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 CDI86194.1 - 7.7e-31 107.4 0.0 8.4e-29 100.7 0.0 2.2 2 0 0 2 2 2 2 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 CDI86194.1 - 1.5e-12 47.9 0.6 1.8e-08 34.6 0.0 3.2 3 0 0 3 3 3 2 Peptidase M16 inactive domain STI1 PF17830.1 CDI86194.1 - 0.051 13.5 0.1 10 6.2 0.1 3.2 2 1 0 2 2 2 0 STI1 domain Asp PF00026.23 CDI86195.1 - 6e-19 68.6 0.0 1.7e-08 34.3 0.0 3.1 2 1 1 3 3 3 3 Eukaryotic aspartyl protease Amidohydro_2 PF04909.14 CDI86197.1 - 4.1e-08 33.3 0.1 6.5e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 CDI86197.1 - 0.00067 19.1 0.1 0.12 11.6 0.1 2.4 3 0 0 3 3 3 2 Amidohydrolase family V-SNARE_C PF12352.8 CDI86198.1 - 2.9e-06 27.5 2.6 2.9e-06 27.5 2.6 2.1 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Prominin PF05478.11 CDI86198.1 - 0.0043 15.1 9.0 0.017 13.1 9.0 1.8 1 1 0 1 1 1 1 Prominin AsnA PF03590.15 CDI86198.1 - 0.1 12.3 1.3 0.13 12.0 0.3 1.6 2 0 0 2 2 2 0 Aspartate-ammonia ligase Sec20 PF03908.13 CDI86198.1 - 0.12 12.3 0.2 0.12 12.3 0.2 2.4 3 1 0 3 3 3 0 Sec20 Syntaxin_2 PF14523.6 CDI86198.1 - 3.8 7.9 15.9 0.37 11.2 7.3 2.7 1 1 1 2 2 2 0 Syntaxin-like protein Aminopep PF10023.9 CDI86198.1 - 6.4 6.0 9.1 1.1 8.6 4.1 1.9 2 0 0 2 2 2 0 Putative aminopeptidase Tam41_Mmp37 PF09139.11 CDI86198.1 - 6.8 6.0 7.5 3.1 7.2 5.2 1.5 1 1 1 2 2 2 0 Phosphatidate cytidylyltransferase, mitochondrial Ribosomal_L28 PF00830.19 CDI86199.1 - 2.5e-06 27.6 2.5 2.7e-06 27.5 0.0 2.3 3 0 0 3 3 3 1 Ribosomal L28 family SET PF00856.28 CDI86201.1 - 2.1e-06 28.2 0.8 0.094 13.1 0.0 3.8 3 1 1 4 4 4 3 SET domain API5 PF05918.11 CDI86201.1 - 9.1 5.0 8.5 20 3.8 8.5 1.5 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF4575 PF15143.6 CDI86202.1 - 0.082 13.1 1.0 0.13 12.4 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4575) TT_ORF1 PF02956.14 CDI86202.1 - 0.49 9.0 3.8 0.65 8.6 3.8 1.1 1 0 0 1 1 1 0 TT viral orf 1 FSA_C PF10479.9 CDI86202.1 - 0.82 7.7 5.5 1 7.4 5.5 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Spore_III_AB PF09548.10 CDI86203.1 - 1.8 8.7 10.3 0.37 10.9 0.1 3.5 4 0 0 4 4 4 0 Stage III sporulation protein AB (spore_III_AB) DEAD PF00270.29 CDI86204.1 - 7.1e-14 52.0 0.0 7.1e-14 52.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase PRP1_N PF06424.12 CDI86206.1 - 0.001 19.5 1.8 0.051 14.0 0.1 2.1 2 0 0 2 2 2 1 PRP1 splicing factor, N-terminal Secretin_N_2 PF07655.13 CDI86206.1 - 0.012 16.1 20.0 0.012 16.1 20.0 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Spt20 PF12090.8 CDI86206.1 - 0.014 15.1 11.5 0.014 15.1 11.5 3.0 2 1 0 2 2 1 0 Spt20 family DUF4834 PF16118.5 CDI86206.1 - 0.22 12.5 0.3 0.22 12.5 0.3 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) NAM-associated PF14303.6 CDI86206.1 - 0.48 11.1 12.7 2.9 8.6 12.9 2.0 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain NPR3 PF03666.13 CDI86206.1 - 0.72 8.6 9.9 0.55 9.0 6.2 1.9 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Corona_nucleoca PF00937.18 CDI86206.1 - 1.4 7.9 21.5 0.022 13.8 14.1 1.7 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein FAM76 PF16046.5 CDI86206.1 - 2.2 7.6 10.1 1.1 8.6 3.8 2.1 2 0 0 2 2 2 0 FAM76 protein RAP1 PF07218.11 CDI86206.1 - 3.5 5.8 19.4 4.6 5.4 19.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF515 PF04415.12 CDI86206.1 - 4.2 5.6 17.0 6.6 5.0 17.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF515) MRI PF15325.6 CDI86206.1 - 4.4 8.4 14.0 3.4 8.8 9.5 2.4 2 0 0 2 2 2 0 Modulator of retrovirus infection Pex14_N PF04695.13 CDI86206.1 - 4.7 7.8 28.9 0.036 14.7 7.2 2.3 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PIP5K PF01504.18 CDI86206.1 - 5.6 6.1 14.2 0.16 11.1 3.5 2.0 1 1 1 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase CCDC106 PF15794.5 CDI86206.1 - 7.8 6.1 15.2 8.9 5.9 11.1 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 TFIIA PF03153.13 CDI86206.1 - 9.6 6.1 34.8 17 5.3 34.8 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI86207.1 - 0.11 11.2 55.3 0.14 10.9 55.3 1.1 1 0 0 1 1 1 0 Presenilin zf-UBP PF02148.19 CDI86209.1 - 0.0099 16.2 0.5 0.015 15.6 0.5 1.3 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Ima1_N PF09779.9 CDI86209.1 - 0.014 16.3 1.4 0.018 15.9 1.4 1.3 1 0 0 1 1 1 0 Ima1 N-terminal domain Apt1 PF10351.9 CDI86209.1 - 0.019 13.9 10.9 0.018 13.9 10.9 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain POX PF07526.11 CDI86209.1 - 0.037 14.6 1.7 0.044 14.3 1.7 1.2 1 0 0 1 1 1 0 Associated with HOX Macoilin PF09726.9 CDI86209.1 - 0.087 11.4 14.6 0.09 11.3 14.6 1.0 1 0 0 1 1 1 0 Macoilin family SpoIIIAH PF12685.7 CDI86209.1 - 0.11 12.4 4.4 0.1 12.4 4.4 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein SPX PF03105.19 CDI86209.1 - 0.13 12.2 16.2 0.13 12.1 16.2 1.0 1 0 0 1 1 1 0 SPX domain RSRP PF17069.5 CDI86209.1 - 0.13 11.8 23.7 0.2 11.2 23.7 1.3 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 zf-HIT PF04438.16 CDI86209.1 - 0.21 11.5 3.0 0.31 11.0 3.0 1.2 1 0 0 1 1 1 0 HIT zinc finger EVI2A PF05399.11 CDI86209.1 - 0.53 9.9 8.9 0.65 9.6 8.9 1.1 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) SSP160 PF06933.11 CDI86209.1 - 0.69 8.0 19.1 0.7 8.0 19.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RAP1 PF07218.11 CDI86209.1 - 0.69 8.1 21.1 0.76 8.0 21.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CDK2AP PF09806.9 CDI86209.1 - 0.78 9.8 8.4 1 9.4 8.4 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DUF1180 PF06679.12 CDI86209.1 - 1 9.8 9.9 1.4 9.3 9.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF3827 PF12877.7 CDI86209.1 - 1.3 7.3 8.7 1.3 7.3 8.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Presenilin PF01080.17 CDI86209.1 - 3.9 6.1 6.6 4.4 6.0 6.6 1.1 1 0 0 1 1 1 0 Presenilin Tmemb_cc2 PF10267.9 CDI86209.1 - 6.5 5.8 6.0 7 5.7 6.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF755 PF05501.11 CDI86210.1 - 0.00029 21.1 16.1 0.00029 21.1 16.1 11.7 8 4 3 11 11 11 1 Domain of unknown function (DUF755) SUIM_assoc PF16619.5 CDI86211.1 - 0.036 14.1 1.1 0.036 14.1 1.1 11.4 6 4 1 7 7 7 0 Unstructured region C-term to UIM in Ataxin3 Kinase-like PF14531.6 CDI86212.1 - 1.5e-05 24.5 0.0 2.2e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.25 CDI86212.1 - 0.017 14.5 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain CHDCT2 PF08074.11 CDI86213.1 - 0.62 10.2 5.1 0.94 9.6 5.1 1.2 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain DUF4736 PF15883.5 CDI86213.1 - 1.4 8.6 11.7 13 5.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) ATP-synt_E PF05680.12 CDI86213.1 - 2.4 8.5 7.2 5 7.5 7.2 1.5 1 0 0 1 1 1 0 ATP synthase E chain TFIIA PF03153.13 CDI86213.1 - 9.1 6.2 17.9 14 5.5 17.9 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CemA PF03040.14 CDI86214.1 - 0.0011 19.0 16.9 0.0012 18.9 3.2 2.1 2 0 0 2 2 2 2 CemA family SARAF PF06682.12 CDI86214.1 - 0.0012 18.6 12.2 0.0012 18.6 12.2 3.1 3 0 0 3 3 3 1 SOCE-associated regulatory factor of calcium homoeostasis Serinc PF03348.15 CDI86214.1 - 0.045 12.7 20.2 0.079 11.9 6.9 2.2 2 0 0 2 2 2 0 Serine incorporator (Serinc) Glyco_hydro_1 PF00232.18 CDI86214.1 - 3.4 6.0 19.9 0.011 14.2 8.8 1.9 1 1 0 2 2 2 0 Glycosyl hydrolase family 1 Peptidase_S49_N PF08496.10 CDI86214.1 - 4.7 7.3 26.5 0.058 13.5 3.7 2.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal SR-25 PF10500.9 CDI86214.1 - 6.2 6.4 53.9 0.13 11.9 4.1 4.0 3 1 1 4 4 4 0 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI86216.1 - 5.4e-05 23.6 37.6 0.00025 21.4 13.5 2.2 1 1 1 2 2 2 2 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI86216.1 - 0.073 12.7 54.9 0.04 13.5 26.1 2.2 2 0 0 2 2 2 0 Spt20 family Apt1 PF10351.9 CDI86216.1 - 0.083 11.7 17.5 0.096 11.5 17.5 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain ArsP_2 PF11449.8 CDI86216.1 - 0.12 11.6 9.8 0.16 11.2 9.8 1.1 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter SR-25 PF10500.9 CDI86216.1 - 0.13 11.9 35.6 0.13 11.9 11.6 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein YL1 PF05764.13 CDI86216.1 - 0.28 11.3 25.4 0.33 11.0 25.4 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Rad54_N PF08658.10 CDI86216.1 - 0.3 11.2 12.0 0.23 11.6 2.6 2.2 2 0 0 2 2 2 0 Rad54 N terminal SARAF PF06682.12 CDI86216.1 - 0.5 10.0 20.0 0.63 9.6 20.0 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis U1snRNP70_N PF12220.8 CDI86216.1 - 1.1 10.0 14.0 2.7 8.7 4.3 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Coilin_N PF15862.5 CDI86216.1 - 1.6 8.5 30.1 1.7 8.5 7.4 2.3 2 0 0 2 2 2 0 Coilin N-terminus Lin-8 PF03353.15 CDI86216.1 - 1.6 8.2 25.1 2.2 7.8 25.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Thg1C PF14413.6 CDI86216.1 - 2.5 8.3 15.0 5.7 7.1 2.0 2.3 2 0 0 2 2 2 0 Thg1 C terminal domain Roughex PF06020.11 CDI86216.1 - 4.3 6.3 26.8 0.19 10.8 12.3 2.1 2 0 0 2 2 2 0 Drosophila roughex protein Pap_E4 PF02711.14 CDI86216.1 - 4.4 8.3 23.0 3.6 8.6 7.2 2.4 2 0 0 2 2 2 0 E4 protein NPR1_interact PF15699.5 CDI86216.1 - 5.1 7.8 18.0 2.4 8.8 2.1 2.4 2 0 0 2 2 2 0 NPR1 interacting EFTUD2 PF16004.5 CDI86216.1 - 6 7.5 22.2 1.7 9.3 7.6 2.3 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Sox_N PF12444.8 CDI86216.1 - 6.1 8.0 22.4 8.9 7.5 7.1 2.7 2 0 0 2 2 2 0 Sox developmental protein N terminal Eaf7 PF07904.13 CDI86216.1 - 6.6 7.2 9.7 12 6.3 4.2 2.3 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 Macoilin PF09726.9 CDI86216.1 - 6.8 5.1 31.5 7.7 4.9 31.5 1.0 1 0 0 1 1 1 0 Macoilin family Peptidase_U57 PF05582.12 CDI86216.1 - 9.3 5.4 15.6 2.1 7.5 5.2 2.1 2 0 0 2 2 2 0 YabG peptidase U57 Macoilin PF09726.9 CDI86217.1 - 0.064 11.8 14.8 0.071 11.7 14.8 1.0 1 0 0 1 1 1 0 Macoilin family DUF2057 PF09829.9 CDI86217.1 - 0.77 9.9 10.4 0.89 9.7 10.4 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) DUF4554 PF15091.6 CDI86217.1 - 0.86 8.4 7.1 0.85 8.4 7.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) UPF0565 PF10561.9 CDI86217.1 - 2.2 7.4 3.8 2.5 7.2 3.8 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Glyco_hydro_9 PF00759.19 CDI86217.1 - 2.2 7.6 9.5 2.3 7.5 9.5 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 DUF3138 PF11336.8 CDI86217.1 - 3.4 6.2 16.4 3.7 6.1 16.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Spt20 PF12090.8 CDI86217.1 - 6.2 6.4 10.0 7 6.2 10.0 1.1 1 0 0 1 1 1 0 Spt20 family Spt20 PF12090.8 CDI86219.1 - 0.00075 19.2 11.2 0.00075 19.2 11.2 2.0 2 0 0 2 2 2 1 Spt20 family eIF3g PF12353.8 CDI86219.1 - 1.1 9.7 5.7 2.3 8.6 5.7 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G Maf1 PF09174.10 CDI86219.1 - 5.9 7.0 5.4 13 5.9 5.4 1.6 1 1 0 1 1 1 0 Maf1 regulator Ribosomal_60s PF00428.19 CDI86220.1 - 0.0012 19.3 2.2 0.0013 19.3 2.2 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein USP19_linker PF16602.5 CDI86220.1 - 0.0016 19.0 1.2 0.0017 18.9 1.2 1.0 1 0 0 1 1 1 1 Linker region of USP19 deubiquitinase Radial_spoke PF04712.12 CDI86220.1 - 0.14 11.0 2.3 0.14 11.0 2.3 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein Cytomega_UL84 PF06284.11 CDI86220.1 - 0.99 7.8 3.6 1.1 7.7 3.6 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein PBP_sp32 PF07222.12 CDI86220.1 - 4.9 6.5 10.2 6.2 6.2 10.2 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF3682 PF12446.8 CDI86220.1 - 9.4 6.7 12.6 14 6.1 12.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3682) Collagen PF01391.18 CDI86221.1 - 3e-06 26.9 23.2 3e-06 26.9 23.2 2.7 3 0 0 3 3 3 1 Collagen triple helix repeat (20 copies) RT_RNaseH PF17917.1 CDI86222.1 - 7.5e-31 106.5 0.1 2.3e-30 105.0 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDI86222.1 - 1.7e-28 98.6 0.0 3.8e-28 97.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDI86222.1 - 6.6e-13 48.9 0.3 2.5e-12 47.0 0.0 2.0 3 0 0 3 3 3 1 Integrase core domain RVP_2 PF08284.11 CDI86223.1 - 1.9e-18 66.5 0.0 2.1e-08 34.0 0.0 2.4 2 0 0 2 2 2 2 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CDI86223.1 - 1.1e-13 51.6 0.0 4.5e-06 27.2 0.0 2.6 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 CDI86223.1 - 1.1e-13 51.5 0.0 3.3e-05 24.3 0.0 2.9 3 0 0 3 3 3 2 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 CDI86223.1 - 1.8e-05 24.5 0.0 0.001 18.9 0.0 2.4 2 0 0 2 2 2 1 Aspartyl protease RVP PF00077.20 CDI86223.1 - 0.0058 16.9 0.0 0.9 9.9 0.0 2.7 2 1 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.23 CDI86223.1 - 0.18 12.0 12.7 2.5 8.3 2.0 2.7 2 0 0 2 2 2 0 Zinc knuckle DnaJ_CXXCXGXG PF00684.19 CDI86223.1 - 0.68 10.3 9.9 28 5.2 0.0 2.7 2 0 0 2 2 2 0 DnaJ central domain TFIIA PF03153.13 CDI86225.1 - 0.00013 22.1 20.8 0.00018 21.6 20.8 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF775 PF05603.12 CDI86225.1 - 0.00018 21.1 3.6 0.00039 20.0 3.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF775) RskA PF10099.9 CDI86225.1 - 0.0036 17.6 24.2 0.0036 17.6 24.2 2.2 2 0 0 2 2 2 1 Anti-sigma-K factor rskA Pex14_N PF04695.13 CDI86225.1 - 0.015 16.0 7.4 0.015 16.0 7.4 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region IHABP4_N PF16174.5 CDI86225.1 - 0.026 15.2 12.1 0.026 15.2 12.1 2.3 2 1 0 2 2 1 0 Intracellular hyaluronan-binding protein 4 N-terminal FHIPEP PF00771.20 CDI86225.1 - 0.031 12.8 3.2 0.038 12.5 3.2 1.1 1 0 0 1 1 1 0 FHIPEP family DUF2722 PF10846.8 CDI86225.1 - 0.047 12.6 17.7 0.087 11.8 17.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Rsa3 PF14615.6 CDI86225.1 - 0.17 11.5 0.3 0.26 10.9 0.3 1.3 1 0 0 1 1 1 0 Ribosome-assembly protein 3 DUF4834 PF16118.5 CDI86225.1 - 0.95 10.5 8.4 1.9 9.5 8.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CCDC53 PF10152.9 CDI86225.1 - 1.3 9.4 18.0 1.6 9.2 6.5 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex TERB2 PF15101.6 CDI86225.1 - 3.9 7.5 10.2 8 6.5 9.6 1.7 2 0 0 2 2 2 0 Telomere-associated protein TERB2 NUDE_C PF04880.13 CDI86225.1 - 5.1 7.5 16.9 1.8 9.0 8.0 2.3 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region Spt20 PF12090.8 CDI86225.1 - 5.2 6.6 28.6 9.6 5.7 28.6 1.3 1 0 0 1 1 1 0 Spt20 family DUF702 PF05142.12 CDI86225.1 - 5.4 7.5 10.9 9.2 6.7 5.7 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF702) UPF0560 PF10577.9 CDI86225.1 - 6.5 5.1 12.9 9.8 4.5 12.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DDRGK PF09756.9 CDI86226.1 - 1.1 8.8 20.0 1.9 8.1 20.0 1.3 1 0 0 1 1 1 0 DDRGK domain CobT PF06213.12 CDI86226.1 - 1.4 8.3 33.4 0.39 10.1 20.6 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Sin_N PF04801.13 CDI86226.1 - 3.1 6.9 32.0 4.9 6.3 32.0 1.3 1 0 0 1 1 1 0 Sin-like protein conserved region EFTUD2 PF16004.5 CDI86226.1 - 4.5 7.9 29.6 7.1 7.2 17.8 2.6 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus DUF4647 PF15504.6 CDI86226.1 - 5 6.1 28.6 6.6 5.7 28.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DUF2828 PF11443.8 CDI86227.1 - 0.0079 14.3 10.0 0.0095 14.1 10.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) TMEM51 PF15345.6 CDI86227.1 - 0.016 15.1 8.4 0.016 15.1 8.4 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 SARAF PF06682.12 CDI86227.1 - 0.024 14.3 18.8 0.03 14.0 18.8 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Mito_fiss_reg PF05308.11 CDI86227.1 - 0.037 14.1 19.1 0.046 13.8 19.1 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator Conotoxin PF02950.17 CDI86227.1 - 0.056 14.5 1.9 0.056 14.5 1.9 2.4 2 0 0 2 2 2 0 Conotoxin PIP5K PF01504.18 CDI86227.1 - 0.063 12.5 8.7 0.081 12.1 8.7 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2052 PF09747.9 CDI86227.1 - 0.15 12.2 13.6 0.2 11.8 13.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) FAM60A PF15396.6 CDI86227.1 - 0.16 12.0 8.6 0.19 11.7 8.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Otopetrin PF03189.13 CDI86227.1 - 0.17 10.6 7.1 0.2 10.4 7.1 1.0 1 0 0 1 1 1 0 Otopetrin SLC12 PF03522.15 CDI86227.1 - 0.21 10.5 13.5 0.24 10.4 13.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Rtf2 PF04641.12 CDI86227.1 - 0.24 10.8 10.5 0.29 10.4 10.5 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger CDC45 PF02724.14 CDI86227.1 - 0.26 9.6 8.7 0.29 9.4 8.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Band_3_cyto PF07565.13 CDI86227.1 - 0.32 10.8 12.3 0.44 10.3 12.3 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Serinc PF03348.15 CDI86227.1 - 0.35 9.7 3.7 0.46 9.4 3.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) CBP_BcsG PF11658.8 CDI86227.1 - 0.39 9.1 9.3 0.46 8.8 9.3 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DUF1980 PF09323.10 CDI86227.1 - 0.49 10.3 9.2 0.76 9.7 9.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) POR_N PF01855.19 CDI86227.1 - 0.51 10.1 3.7 0.6 9.8 3.7 1.1 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg WRNPLPNID PF15017.6 CDI86227.1 - 0.6 11.0 14.6 0.69 10.8 4.6 2.1 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box Velvet PF11754.8 CDI86227.1 - 0.7 9.8 16.2 0.86 9.5 16.2 1.1 1 0 0 1 1 1 0 Velvet factor ALMT PF11744.8 CDI86227.1 - 0.81 8.5 10.4 0.96 8.2 10.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Peptidase_S49_N PF08496.10 CDI86227.1 - 0.84 9.7 11.8 0.79 9.8 2.8 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Herpes_DNAp_acc PF04929.12 CDI86227.1 - 0.92 8.4 13.2 1.2 8.0 13.2 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor RR_TM4-6 PF06459.12 CDI86227.1 - 1 9.2 16.0 1.3 8.8 16.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peroxin-13_N PF04088.13 CDI86227.1 - 1.1 9.5 9.2 0.59 10.4 2.3 2.0 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Endostatin PF06482.11 CDI86227.1 - 1.2 8.5 15.0 1.4 8.3 15.0 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF4551 PF15087.6 CDI86227.1 - 1.5 7.6 15.7 1.7 7.4 15.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SID-1_RNA_chan PF13965.6 CDI86227.1 - 1.5 7.1 3.3 2.1 6.7 3.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Gti1_Pac2 PF09729.9 CDI86227.1 - 1.6 8.8 12.0 2.5 8.2 12.0 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family GRP PF07172.11 CDI86227.1 - 1.9 9.2 6.7 0.57 10.9 0.5 2.1 2 0 0 2 2 2 0 Glycine rich protein family CAP_N PF01213.19 CDI86227.1 - 1.9 7.9 22.6 4 6.8 22.7 1.5 1 1 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Membralin PF09746.9 CDI86227.1 - 3.3 6.7 6.7 4 6.4 6.7 1.2 1 0 0 1 1 1 0 Tumour-associated protein AUX_IAA PF02309.16 CDI86227.1 - 3.3 7.5 10.2 3.9 7.2 10.2 1.1 1 0 0 1 1 1 0 AUX/IAA family Ndc1_Nup PF09531.10 CDI86227.1 - 4 6.0 17.5 4.4 5.9 17.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PA26 PF04636.13 CDI86227.1 - 4.4 6.1 12.3 5.5 5.8 12.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) O-antigen_lig PF13425.6 CDI86227.1 - 4.9 5.8 5.7 6.2 5.5 5.7 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SWIRM-assoc_2 PF16496.5 CDI86227.1 - 6.7 5.5 18.0 8.5 5.1 18.0 1.0 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Presenilin PF01080.17 CDI86227.1 - 7.2 5.3 23.6 9.2 4.9 23.6 1.0 1 0 0 1 1 1 0 Presenilin DUF3458 PF11940.8 CDI86228.1 - 0.0024 18.3 3.3 0.19 12.2 3.3 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold DUF1180 PF06679.12 CDI86228.1 - 0.053 13.9 2.4 0.065 13.6 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF1645 PF07816.11 CDI86230.1 - 0.82 10.2 0.0 0.82 10.2 0.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1645) Glyco_hydro_9 PF00759.19 CDI86230.1 - 0.99 8.8 20.6 0.022 14.2 3.8 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 9 SR-25 PF10500.9 CDI86230.1 - 1.9 8.0 29.7 2 8.0 4.6 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI86230.1 - 9.7 6.1 10.1 14 5.6 10.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI86231.1 - 3.1e-05 23.7 24.4 4.8e-05 23.1 17.8 2.0 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein TCP PF03634.13 CDI86231.1 - 0.24 11.9 26.6 0.64 10.6 17.4 2.1 2 0 0 2 2 2 0 TCP family transcription factor DUF533 PF04391.12 CDI86231.1 - 0.79 9.3 21.4 0.38 10.3 3.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF533) G0-G1_switch_2 PF15103.6 CDI86231.1 - 1.1 9.7 16.1 3 8.3 6.9 2.2 2 0 0 2 2 2 0 G0/G1 switch protein 2 ORC_WH_C PF18137.1 CDI86231.1 - 2 8.5 17.3 3.6 7.7 7.2 2.2 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal WDCP PF15390.6 CDI86231.1 - 2.7 6.3 23.5 3.3 6.0 23.5 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family DUF2681 PF10883.8 CDI86231.1 - 2.7 8.5 39.1 0.22 11.9 5.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) CD20 PF04103.15 CDI86231.1 - 2.9 8.0 9.5 0.68 10.0 3.3 2.1 1 1 1 2 2 2 0 CD20-like family SWI-SNF_Ssr4 PF08549.10 CDI86231.1 - 4.4 5.8 25.8 5.1 5.6 25.8 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF3499 PF12005.8 CDI86231.1 - 4.6 7.9 11.6 8.4 7.0 4.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3499) DUF1387 PF07139.11 CDI86231.1 - 4.6 6.9 28.5 5.9 6.5 28.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) eIF3_subunit PF08597.10 CDI86231.1 - 7.6 6.4 19.7 5.9 6.7 8.8 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit SR-25 PF10500.9 CDI86232.1 - 1.4 8.5 110.5 0.071 12.7 8.3 4.2 3 1 1 4 4 4 0 Nuclear RNA-splicing-associated protein Myosin_head PF00063.21 CDI86233.1 - 9.5e-167 556.2 0.1 2e-135 452.6 0.0 2.2 1 1 1 2 2 2 2 Myosin head (motor domain) AAA_16 PF13191.6 CDI86233.1 - 0.016 15.6 0.0 0.04 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 CDI86233.1 - 0.062 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 CDI86233.1 - 0.068 13.6 0.1 0.5 10.8 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_22 PF13401.6 CDI86233.1 - 0.073 13.3 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 CDI86233.1 - 0.089 12.8 0.1 0.14 12.2 0.1 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_6 PF12774.7 CDI86233.1 - 0.095 11.7 0.1 0.18 10.7 0.1 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region ABC_tran PF00005.27 CDI86233.1 - 0.16 12.5 0.0 0.39 11.2 0.0 1.8 1 0 0 1 1 1 0 ABC transporter TsaE PF02367.17 CDI86233.1 - 0.16 12.0 0.0 0.4 10.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 CDI86233.1 - 0.16 12.3 0.0 0.36 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 CDI86234.1 - 4e-63 212.5 0.2 5.9e-63 211.9 0.2 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CDI86234.1 - 6.9e-31 106.5 0.0 5.7e-30 103.6 0.0 2.4 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 CDI86234.1 - 4e-19 68.4 0.0 9.2e-19 67.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 CDI86234.1 - 9.4e-15 54.5 0.0 2.5e-14 53.1 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 CDI86234.1 - 3.2e-11 43.4 0.0 7.7e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDI86234.1 - 6.4e-05 23.0 0.1 0.00014 21.9 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 CDI86234.1 - 0.024 14.4 0.0 0.046 13.5 0.0 1.4 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain Shikimate_DH PF01488.20 CDI86234.1 - 0.03 14.4 0.0 0.52 10.4 0.0 2.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase SRPRB PF09439.10 CDI86234.1 - 0.087 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF1345 PF07077.11 CDI86235.1 - 3.8 7.2 8.4 0.46 10.2 3.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) FAM60A PF15396.6 CDI86236.1 - 0.00097 19.2 21.4 0.0012 18.9 21.4 1.1 1 0 0 1 1 1 1 Protein Family FAM60A SRP-alpha_N PF04086.13 CDI86236.1 - 0.066 13.1 21.4 0.079 12.9 21.4 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RR_TM4-6 PF06459.12 CDI86236.1 - 0.19 11.5 25.5 0.23 11.3 25.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4667 PF15700.5 CDI86236.1 - 0.67 10.0 25.9 0.81 9.7 25.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) Zip PF02535.22 CDI86236.1 - 0.71 9.0 20.6 0.82 8.8 20.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SLC12 PF03522.15 CDI86236.1 - 1.1 8.2 26.5 1.3 8.0 26.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 CDI86236.1 - 2 7.1 33.8 2.2 7.0 33.8 1.0 1 0 0 1 1 1 0 Presenilin DUF1387 PF07139.11 CDI86236.1 - 2 8.1 23.9 2.7 7.7 23.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF4045 PF13254.6 CDI86236.1 - 3.5 7.2 24.3 3.7 7.1 24.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) V_ATPase_I PF01496.19 CDI86236.1 - 4.2 5.2 25.9 5.5 4.8 25.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LAP1C PF05609.12 CDI86236.1 - 4.2 6.3 26.8 5.2 6.0 26.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) HCO3_cotransp PF00955.21 CDI86236.1 - 5.1 5.8 10.4 5.8 5.6 10.4 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF572 PF04502.13 CDI86236.1 - 5.4 6.5 22.6 6.5 6.3 22.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Rtf2 PF04641.12 CDI86236.1 - 6.2 6.1 20.8 8.1 5.7 20.8 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2052 PF09747.9 CDI86236.1 - 6.9 6.7 26.5 8 6.5 26.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Lin-8 PF03353.15 CDI86236.1 - 7.1 6.1 31.6 9.4 5.7 31.6 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CCSAP PF15748.5 CDI86236.1 - 7.3 6.7 31.9 8.8 6.4 31.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Sec62 PF03839.16 CDI86236.1 - 7.6 6.0 21.3 10 5.6 21.3 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4422 PF14393.6 CDI86236.1 - 7.6 6.3 12.1 9.9 5.9 12.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4422) NPR3 PF03666.13 CDI86236.1 - 9.4 4.9 26.0 11 4.6 26.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SR-25 PF10500.9 CDI86237.1 - 1.4e-05 24.8 42.4 0.00027 20.6 30.4 2.3 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein Dehydrin PF00257.19 CDI86237.1 - 0.0024 18.4 4.4 0.0024 18.4 4.4 4.9 3 1 0 3 3 3 1 Dehydrin DUF2722 PF10846.8 CDI86237.1 - 0.0039 16.2 8.7 0.0039 16.2 8.7 3.1 2 1 1 3 3 3 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI86237.1 - 0.0046 16.6 15.9 0.0046 16.6 15.9 3.0 2 1 1 3 3 3 1 Spt20 family Suf PF05843.14 CDI86237.1 - 0.42 10.6 35.4 0.3 11.0 4.8 2.5 2 1 0 2 2 2 0 Suppressor of forked protein (Suf) RNF111_N PF15303.6 CDI86238.1 - 0.11 12.2 5.7 0.26 11.0 5.7 1.6 1 1 0 1 1 1 0 E3 ubiquitin-protein ligase Arkadia N-terminus RskA PF10099.9 CDI86238.1 - 3.2 8.0 30.6 3.1 8.1 12.1 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI86239.1 - 0.0043 16.7 15.0 0.0043 16.7 15.0 13.3 7 4 5 13 13 13 2 Spt20 family FHIPEP PF00771.20 CDI86240.1 - 2.8 6.3 22.2 0.69 8.3 1.0 2.3 2 0 0 2 2 2 0 FHIPEP family LAP1C PF05609.12 CDI86240.1 - 3.9 6.5 34.1 5 6.1 34.1 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF2967 PF11179.8 CDI86241.1 - 0.026 12.6 16.3 0.035 12.2 16.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) SR-25 PF10500.9 CDI86241.1 - 3 7.4 16.8 6.4 6.3 16.8 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAM199X PF15814.5 CDI86241.1 - 8.5 5.3 12.7 9.7 5.1 12.7 1.1 1 0 0 1 1 1 0 Protein family FAM199X Suf PF05843.14 CDI86241.1 - 8.7 6.2 14.4 8.5 6.3 14.4 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PCI PF01399.27 CDI86242.1 - 9.2e-15 55.1 0.0 1.2e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 PCI domain pPIWI_RE_X PF13111.6 CDI86242.1 - 0.091 11.9 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 pPIWI_RE module N-terminal domain DUF2722 PF10846.8 CDI86243.1 - 0.0012 17.9 6.2 0.0012 17.9 6.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI86243.1 - 0.0012 18.5 9.9 0.0012 18.5 9.9 1.2 1 0 0 1 1 1 1 Spt20 family Pex14_N PF04695.13 CDI86243.1 - 0.0053 17.4 4.1 0.008 16.8 4.1 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Ca_hom_mod PF14798.6 CDI86243.1 - 0.19 10.8 5.5 0.25 10.4 5.5 1.1 1 0 0 1 1 1 0 Calcium homeostasis modulator DUF2489 PF10675.9 CDI86243.1 - 3.5 7.6 15.6 4.2 7.3 15.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2489) RCC1_2 PF13540.6 CDI86245.1 - 1.3e-06 28.1 0.4 0.0013 18.4 0.1 4.4 5 0 0 5 5 4 1 Regulator of chromosome condensation (RCC1) repeat TFIIA PF03153.13 CDI86245.1 - 1.5e-05 25.2 51.1 0.00078 19.5 7.9 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI86245.1 - 0.00012 22.3 8.9 0.0041 17.3 1.4 2.2 2 0 0 2 2 2 2 DDHD domain RCC1 PF00415.18 CDI86245.1 - 0.00014 22.4 0.0 0.68 10.6 0.0 3.9 4 0 0 4 4 3 1 Regulator of chromosome condensation (RCC1) repeat IER PF05760.12 CDI86245.1 - 0.00045 20.6 5.2 0.00045 20.6 5.2 2.2 2 0 0 2 2 2 1 Immediate early response protein (IER) Velvet PF11754.8 CDI86245.1 - 0.0015 18.6 9.5 0.01 15.8 1.8 2.2 2 0 0 2 2 2 1 Velvet factor Band_3_cyto PF07565.13 CDI86245.1 - 0.0018 18.1 10.1 0.08 12.7 3.6 2.4 2 0 0 2 2 2 2 Band 3 cytoplasmic domain ASC PF00858.24 CDI86245.1 - 0.002 17.1 0.1 0.003 16.6 0.1 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel DUF2722 PF10846.8 CDI86245.1 - 0.0022 17.0 16.1 0.0022 17.0 16.1 3.1 3 0 0 3 3 2 1 Protein of unknown function (DUF2722) BAF1_ABF1 PF04684.13 CDI86245.1 - 0.0028 16.8 8.8 0.023 13.8 1.0 2.1 2 0 0 2 2 2 2 BAF1 / ABF1 chromatin reorganising factor Suf PF05843.14 CDI86245.1 - 0.0032 17.5 25.4 0.016 15.2 2.2 2.3 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) Connexin PF00029.19 CDI86245.1 - 0.011 15.5 13.9 0.021 14.6 5.2 2.1 2 0 0 2 2 2 0 Connexin Presenilin PF01080.17 CDI86245.1 - 0.012 14.5 18.4 0.022 13.5 6.7 2.1 2 0 0 2 2 2 0 Presenilin eIF-3_zeta PF05091.12 CDI86245.1 - 0.021 13.9 28.8 0.11 11.5 15.3 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ndc1_Nup PF09531.10 CDI86245.1 - 0.027 13.2 10.0 0.046 12.4 2.5 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Isy1 PF06246.12 CDI86245.1 - 0.032 13.8 18.8 0.53 9.8 7.3 2.1 2 0 0 2 2 2 0 Isy1-like splicing family MecA PF05389.12 CDI86245.1 - 0.054 13.1 14.9 1 9.0 0.7 2.3 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) UPF0565 PF10561.9 CDI86245.1 - 0.058 12.6 4.4 0.55 9.4 0.4 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 DUF572 PF04502.13 CDI86245.1 - 0.062 12.9 12.9 0.6 9.7 5.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) CCDC53 PF10152.9 CDI86245.1 - 0.073 13.5 20.3 0.39 11.1 1.2 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex PAT1 PF09770.9 CDI86245.1 - 0.12 10.6 35.1 0.22 9.8 4.2 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 CCSAP PF15748.5 CDI86245.1 - 0.14 12.3 20.5 1.3 9.2 1.9 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DUF2370 PF10176.9 CDI86245.1 - 0.15 11.7 5.2 2.8 7.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) Neur_chan_memb PF02932.16 CDI86245.1 - 0.16 12.0 14.9 1.7 8.7 8.1 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region TCP PF03634.13 CDI86245.1 - 0.17 12.4 17.3 1.8 9.1 1.1 2.5 2 0 0 2 2 2 0 TCP family transcription factor EOS1 PF12326.8 CDI86245.1 - 0.17 11.8 9.3 4.4 7.2 0.1 2.2 2 0 0 2 2 2 0 N-glycosylation protein PIP5K PF01504.18 CDI86245.1 - 0.19 10.9 10.9 1.7 7.8 0.1 2.2 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Afi1 PF07792.12 CDI86245.1 - 0.22 12.0 19.0 1 9.9 9.5 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RR_TM4-6 PF06459.12 CDI86245.1 - 0.25 11.1 20.0 1.5 8.6 2.0 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 V_ATPase_I PF01496.19 CDI86245.1 - 0.27 9.1 22.8 0.13 10.1 12.5 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF5427 PF10310.9 CDI86245.1 - 0.27 10.1 21.7 0.3 10.0 10.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5427) DUF2828 PF11443.8 CDI86245.1 - 0.27 9.2 16.0 1.2 7.1 0.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) DUF4050 PF13259.6 CDI86245.1 - 0.41 10.9 14.9 2.9 8.2 7.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) BORG_CEP PF14957.6 CDI86245.1 - 0.43 11.8 11.7 5.6 8.2 5.6 2.4 2 0 0 2 2 2 0 Cdc42 effector Peptidase_S49_N PF08496.10 CDI86245.1 - 0.47 10.5 22.4 0.077 13.1 7.2 2.7 3 0 0 3 3 2 0 Peptidase family S49 N-terminal Ctr PF04145.15 CDI86245.1 - 0.55 10.8 9.6 6.3 7.4 3.6 2.3 2 0 0 2 2 2 0 Ctr copper transporter family SAGA-Tad1 PF12767.7 CDI86245.1 - 0.61 9.8 14.6 2.6 7.7 6.7 2.2 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit CAC1F_C PF16885.5 CDI86245.1 - 0.61 9.7 14.8 1.7 8.2 1.0 2.1 2 0 0 2 2 2 0 Voltage-gated calcium channel subunit alpha, C-term DUF4228 PF14009.6 CDI86245.1 - 0.7 10.3 10.7 5.9 7.2 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) Peptidase_S15 PF02129.18 CDI86245.1 - 0.72 9.4 16.9 2.2 7.8 3.2 2.3 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF4366 PF14283.6 CDI86245.1 - 0.82 9.7 8.4 7.7 6.6 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) CDC45 PF02724.14 CDI86245.1 - 0.92 7.7 13.8 1.3 7.2 0.4 2.2 2 0 0 2 2 2 0 CDC45-like protein DUF3801 PF12687.7 CDI86245.1 - 1.2 9.2 20.2 2.6 8.1 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) TFIIF_beta_N PF17683.1 CDI86245.1 - 1.2 9.8 17.6 0.28 11.9 7.3 2.3 2 0 0 2 2 2 0 TFIIF, beta subunit N-terminus MMU163 PF17119.5 CDI86245.1 - 1.2 8.2 9.7 4.2 6.5 0.4 2.3 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis MIIP PF15734.5 CDI86245.1 - 1.4 8.3 16.3 2.4 7.6 8.0 2.1 2 0 0 2 2 2 0 Migration and invasion-inhibitory Lin-8 PF03353.15 CDI86245.1 - 1.5 8.3 23.4 0.91 9.0 11.5 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist PepSY_TM PF03929.16 CDI86245.1 - 1.7 8.2 10.5 1.5 8.4 2.3 2.4 2 0 0 2 2 2 0 PepSY-associated TM region CAF1 PF04857.20 CDI86245.1 - 1.8 7.6 12.2 4 6.5 0.0 2.1 2 0 0 2 2 2 0 CAF1 family ribonuclease Zip PF02535.22 CDI86245.1 - 2.2 7.4 6.4 2.8 7.1 0.7 2.4 3 0 0 3 3 2 0 ZIP Zinc transporter DUF4638 PF15472.6 CDI86245.1 - 2.3 7.9 18.2 1.3 8.7 8.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) FAM60A PF15396.6 CDI86245.1 - 2.4 8.1 17.8 5.7 6.9 8.7 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Trp_oprn_chp PF09534.10 CDI86245.1 - 2.7 7.8 6.4 17 5.1 0.5 3.3 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF913 PF06025.12 CDI86245.1 - 3.1 6.7 11.1 4.4 6.2 4.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) PPL5 PF18168.1 CDI86245.1 - 3.4 6.9 14.4 0.57 9.4 4.0 2.2 2 0 0 2 2 2 0 Prim-pol family 5 DUF775 PF05603.12 CDI86245.1 - 3.8 7.0 27.8 0.37 10.3 10.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF775) SET PF00856.28 CDI86245.1 - 3.9 7.8 10.8 9.5e+02 0.1 10.8 2.3 1 1 0 1 1 1 0 SET domain DUF3807 PF12720.7 CDI86245.1 - 4.5 7.5 32.8 3.9 7.7 15.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) PNISR PF15996.5 CDI86245.1 - 4.9 7.4 28.7 2.4 8.4 13.4 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR MMM1 PF10296.9 CDI86245.1 - 5.1 6.0 14.0 5.5 5.9 6.6 2.2 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 DcuA_DcuB PF03605.14 CDI86245.1 - 5.5 5.8 6.9 10 4.9 1.3 2.2 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter SLC12 PF03522.15 CDI86245.1 - 5.6 5.9 21.2 3.9 6.4 11.0 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Eapp_C PF10238.9 CDI86245.1 - 6 6.9 27.2 2.4 8.2 12.5 2.5 2 1 0 2 2 2 0 E2F-associated phosphoprotein Orf78 PF06024.12 CDI86245.1 - 6.1 7.2 17.7 8.9 6.7 1.6 3.1 3 0 0 3 3 3 0 Orf78 (ac78) TMEM174 PF15029.6 CDI86245.1 - 6.2 6.5 7.7 6.8 6.3 0.2 2.6 2 0 0 2 2 2 0 Transmembrane protein 174 IHABP4_N PF16174.5 CDI86245.1 - 6.4 7.4 29.9 6 7.4 7.5 2.3 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal N6_N4_Mtase PF01555.18 CDI86245.1 - 6.6 6.4 8.6 2.3 7.8 0.6 2.6 2 1 0 2 2 2 0 DNA methylase Kei1 PF08552.11 CDI86245.1 - 6.7 6.5 15.4 4.4 7.1 1.5 2.3 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 MAM33 PF02330.16 CDI86245.1 - 6.8 6.6 23.2 0.059 13.3 2.7 2.9 3 1 0 3 3 2 0 Mitochondrial glycoprotein DUF5523 PF17661.1 CDI86245.1 - 7.3 6.2 23.8 4.5 6.9 10.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5523) TFB6 PF17110.5 CDI86245.1 - 7.9 6.2 12.1 2.9 7.6 2.7 2.3 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Ketoacyl-synt_2 PF13723.6 CDI86245.1 - 8.7 5.9 29.3 0.9 9.1 3.3 2.4 2 1 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain XAP5 PF04921.14 CDI86245.1 - 9 6.0 14.5 4.7 7.0 4.4 2.3 2 0 0 2 2 2 0 XAP5, circadian clock regulator DUF4569 PF15133.6 CDI86245.1 - 9 5.9 27.2 4.3 7.0 3.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4569) Rhomboid PF01694.22 CDI86246.1 - 5.8e-26 91.3 13.7 5.8e-26 91.3 13.7 1.6 2 0 0 2 2 2 1 Rhomboid family Kei1 PF08552.11 CDI86246.1 - 2 8.2 5.8 3.6 7.4 0.4 2.3 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Band_3_cyto PF07565.13 CDI86247.1 - 0.58 9.9 4.7 0.9 9.3 4.7 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Rad54_N PF08658.10 CDI86248.1 - 0.38 10.9 13.9 0.57 10.3 13.9 1.3 1 0 0 1 1 1 0 Rad54 N terminal Pox_Ag35 PF03286.14 CDI86248.1 - 0.58 9.9 18.3 0.63 9.8 18.3 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein MAJIN PF15077.6 CDI86248.1 - 1.2 8.9 18.4 1.3 8.7 18.4 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein RR_TM4-6 PF06459.12 CDI86248.1 - 3.4 7.4 27.0 3.9 7.2 27.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pex14_N PF04695.13 CDI86248.1 - 3.4 8.3 30.9 4.4 8.0 30.9 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region eIF3_subunit PF08597.10 CDI86248.1 - 3.6 7.4 25.7 4.5 7.1 25.7 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit MCM_bind PF09739.9 CDI86248.1 - 3.7 5.9 22.6 4.1 5.7 22.6 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CCSAP PF15748.5 CDI86248.1 - 3.8 7.6 28.2 4 7.5 28.2 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated eIF-3_zeta PF05091.12 CDI86248.1 - 3.9 6.3 25.7 4.4 6.2 25.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Kei1 PF08552.11 CDI86248.1 - 4 7.3 14.3 5.6 6.8 14.3 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 HGTP_anticodon2 PF12745.7 CDI86248.1 - 4.2 6.8 20.6 4.4 6.7 20.6 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs BORG_CEP PF14957.6 CDI86248.1 - 4.3 8.5 18.3 5.2 8.2 18.3 1.1 1 0 0 1 1 1 0 Cdc42 effector CDC45 PF02724.14 CDI86248.1 - 4.4 5.5 24.7 4.4 5.5 24.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Paf1 PF03985.13 CDI86248.1 - 4.5 6.2 28.1 5.4 5.9 28.1 1.2 1 0 0 1 1 1 0 Paf1 NPR3 PF03666.13 CDI86248.1 - 4.6 5.9 21.5 5.3 5.7 21.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 CDI86248.1 - 5.7 5.6 29.2 6.4 5.4 29.2 1.0 1 0 0 1 1 1 0 Presenilin VIR_N PF15912.5 CDI86248.1 - 5.9 6.4 21.3 6.8 6.2 21.3 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal FAM60A PF15396.6 CDI86248.1 - 6.4 6.7 19.4 7.9 6.4 19.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A PAT1 PF09770.9 CDI86248.1 - 6.8 4.8 36.0 7.2 4.7 36.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Lin-8 PF03353.15 CDI86248.1 - 6.9 6.1 28.8 7.2 6.1 28.8 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SLC12 PF03522.15 CDI86248.1 - 6.9 5.6 25.0 7.3 5.5 25.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4628 PF15429.6 CDI86248.1 - 7 6.2 20.6 8.6 5.9 20.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) Rtf2 PF04641.12 CDI86248.1 - 7.1 5.9 23.9 7.8 5.8 23.9 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Neur_chan_memb PF02932.16 CDI86248.1 - 8 6.5 18.7 8.4 6.4 18.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Endostatin PF06482.11 CDI86248.1 - 8.3 5.8 20.8 9.3 5.6 20.8 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF1645 PF07816.11 CDI86249.1 - 0.013 16.1 0.8 0.013 16.1 0.8 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1645) DUF1345 PF07077.11 CDI86249.1 - 0.069 12.8 9.2 0.066 12.9 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) SARAF PF06682.12 CDI86249.1 - 0.23 11.1 14.0 0.3 10.7 1.9 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis BORG_CEP PF14957.6 CDI86249.1 - 0.25 12.5 8.3 1.7 9.8 0.7 2.5 2 0 0 2 2 2 0 Cdc42 effector Neur_chan_memb PF02932.16 CDI86249.1 - 0.29 11.2 10.2 0.38 10.8 0.7 2.5 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region BPD_transp_2 PF02653.16 CDI86249.1 - 1.8 7.6 6.7 0.076 12.2 0.3 1.9 2 1 0 2 2 2 0 Branched-chain amino acid transport system / permease component Tsc35 PF15079.6 CDI86249.1 - 3.2 7.3 9.7 0.09 12.3 2.3 1.9 2 0 0 2 2 2 0 Testis-specific protein 35 DUF572 PF04502.13 CDI86249.1 - 3.9 7.0 9.2 8.7 5.9 2.7 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) RPN2_C PF18004.1 CDI86250.1 - 0.0038 17.2 21.7 0.0042 17.0 21.7 1.0 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain XRCC4 PF06632.12 CDI86250.1 - 0.31 9.8 18.9 0.31 9.9 18.9 1.0 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 CobT PF06213.12 CDI86250.1 - 0.72 9.2 33.6 0.82 9.0 33.6 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT AIF_C PF14721.6 CDI86250.1 - 2.5 8.5 17.5 2.8 8.3 17.5 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FAM176 PF14851.6 CDI86250.1 - 2.5 7.8 17.1 2.9 7.6 17.1 1.1 1 0 0 1 1 1 0 FAM176 family FYDLN_acid PF09538.10 CDI86250.1 - 2.5 8.8 15.6 3 8.6 15.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) RR_TM4-6 PF06459.12 CDI86250.1 - 2.5 7.8 24.0 2.6 7.8 24.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SpoIIP PF07454.11 CDI86250.1 - 3.5 7.0 25.6 3.8 6.9 25.6 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Hid1 PF12722.7 CDI86250.1 - 5.2 5.1 22.6 5.3 5.0 22.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1682 PF07946.14 CDI86250.1 - 5.2 6.2 26.2 5.3 6.2 26.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Pex14_N PF04695.13 CDI86250.1 - 5.5 7.6 28.9 5.6 7.6 28.9 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CCDC53 PF10152.9 CDI86250.1 - 5.9 7.3 23.1 6.2 7.2 23.1 1.0 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex TRAP_alpha PF03896.16 CDI86250.1 - 5.9 6.0 15.1 6.3 5.9 15.1 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Connexin PF00029.19 CDI86250.1 - 6.7 6.4 20.9 7.3 6.3 20.9 1.0 1 0 0 1 1 1 0 Connexin Paf1 PF03985.13 CDI86250.1 - 7.2 5.5 28.6 7.4 5.5 28.6 1.0 1 0 0 1 1 1 0 Paf1 DUF1764 PF08576.10 CDI86250.1 - 7.4 7.5 21.1 8.6 7.3 21.1 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Presenilin PF01080.17 CDI86250.1 - 8.7 5.0 27.3 8.6 5.0 27.3 1.0 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 CDI86250.1 - 9.4 4.9 22.6 9 5.0 22.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MCM_bind PF09739.9 CDI86250.1 - 10 4.5 22.8 11 4.4 22.8 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Rabaptin PF03528.15 CDI86251.1 - 0.12 11.0 18.9 0.15 10.7 18.9 1.2 1 0 0 1 1 1 0 Rabaptin TMF_TATA_bd PF12325.8 CDI86251.1 - 0.45 10.7 15.8 0.092 13.0 11.8 1.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Exonuc_VII_L PF02601.15 CDI86251.1 - 1.4 8.4 17.4 1.7 8.2 17.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4776 PF16003.5 CDI86251.1 - 2.1 7.2 9.3 2.4 7.0 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) YjbH PF06082.11 CDI86251.1 - 3.2 6.5 13.8 3.6 6.3 13.8 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH DUF966 PF06136.13 CDI86251.1 - 3.5 7.3 10.1 4.3 7.0 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TFIIA PF03153.13 CDI86251.1 - 5.2 7.0 27.2 7.4 6.4 27.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Fmp27_WPPW PF10359.9 CDI86251.1 - 6.3 5.5 11.5 8.6 5.1 11.5 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Trehalase PF01204.18 CDI86256.1 - 2.7e-29 102.4 0.0 3.5e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Trehalase DHODB_Fe-S_bind PF10418.9 CDI86256.1 - 0.14 12.0 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B PP2C PF00481.21 CDI86257.1 - 3.3e-17 63.0 0.1 3.4e-16 59.7 0.0 1.9 1 1 1 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 CDI86257.1 - 9.2e-05 22.2 0.0 0.00079 19.1 0.0 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 CDI86257.1 - 0.063 13.2 0.0 3.1 7.7 0.0 2.5 1 1 1 2 2 2 0 Stage II sporulation protein E (SpoIIE) DUF3987 PF13148.6 CDI86258.1 - 0.015 14.3 1.6 0.027 13.5 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) CSD PF00313.22 CDI86259.1 - 1.4e-23 82.5 0.3 2.5e-23 81.7 0.3 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CDI86259.1 - 0.003 17.2 0.1 0.0058 16.3 0.1 1.5 1 0 0 1 1 1 1 Ribonuclease B OB domain Prenyltrans PF00432.21 CDI86260.1 - 6.8e-20 70.5 27.2 8.6e-08 31.8 0.1 7.7 7 1 0 7 7 7 6 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CDI86260.1 - 0.09 11.9 0.0 1.3 8.1 0.0 2.4 2 0 0 2 2 2 0 Squalene-hopene cyclase N-terminal domain SUIM_assoc PF16619.5 CDI86260.1 - 3.8 7.6 11.6 9.2 6.4 0.0 3.7 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 CDI86261.1 - 2.6e-59 200.7 0.0 4e-59 200.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI86261.1 - 1.6e-35 122.6 0.0 2.8e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI86261.1 - 0.0056 15.5 0.0 0.0056 15.5 0.0 2.2 3 0 0 3 3 3 1 Fungal protein kinase APH PF01636.23 CDI86261.1 - 8.5 6.2 9.6 0.54 10.1 0.0 2.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family GSH-S_ATP PF02955.16 CDI86262.1 - 0.046 13.1 0.0 0.38 10.1 0.0 2.1 2 0 0 2 2 2 0 Prokaryotic glutathione synthetase, ATP-grasp domain OmpH PF03938.14 CDI86262.1 - 0.046 14.0 2.7 0.084 13.2 2.7 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) UPF0113_N PF17833.1 CDI86263.1 - 2.5e-26 92.0 0.1 3.7e-26 91.5 0.1 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 CDI86263.1 - 8.5e-17 61.2 0.0 1.3e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 UPF0113 PUA domain MMR_HSR1 PF01926.23 CDI86264.1 - 5.8e-40 135.9 0.0 3.7e-19 68.9 0.0 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase KH_dom-like PF14714.6 CDI86264.1 - 1.2e-26 92.8 0.1 6.7e-26 90.4 0.1 2.2 2 0 0 2 2 2 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.18 CDI86264.1 - 2.4e-17 62.9 0.0 5.1e-10 39.1 0.0 3.8 3 1 0 3 3 3 2 Ferrous iron transport protein B AIG1 PF04548.16 CDI86264.1 - 5.1e-13 48.9 0.0 2.2e-05 23.9 0.1 2.6 2 1 0 2 2 2 2 AIG1 family Dynamin_N PF00350.23 CDI86264.1 - 6.2e-12 45.9 0.4 0.0014 18.7 0.1 4.2 3 1 1 4 4 4 2 Dynamin family RsgA_GTPase PF03193.16 CDI86264.1 - 6.9e-12 45.6 0.1 0.049 13.5 0.0 4.5 4 0 0 4 4 4 4 RsgA GTPase GTP_EFTU PF00009.27 CDI86264.1 - 1e-11 44.8 0.2 0.00013 21.5 0.1 5.7 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain Roc PF08477.13 CDI86264.1 - 1.5e-07 31.7 0.0 0.0073 16.5 0.0 3.3 3 1 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 CDI86264.1 - 9.1e-07 28.5 0.0 0.013 14.9 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Ras PF00071.22 CDI86264.1 - 6.2e-06 25.9 0.1 0.026 14.1 0.0 3.3 3 1 0 3 3 3 2 Ras family Arf PF00025.21 CDI86264.1 - 0.00098 18.6 0.2 0.0083 15.6 0.1 2.6 2 1 0 2 2 2 1 ADP-ribosylation factor family TniB PF05621.11 CDI86264.1 - 0.0071 15.8 0.0 5.6 6.3 0.0 2.8 3 0 0 3 3 3 2 Bacterial TniB protein ABC_tran PF00005.27 CDI86264.1 - 0.0082 16.7 0.0 2.6 8.6 0.0 3.2 3 0 0 3 3 3 1 ABC transporter SRPRB PF09439.10 CDI86264.1 - 0.027 13.9 0.0 2.1 7.8 0.0 2.8 2 1 1 3 3 3 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 CDI86264.1 - 0.049 14.0 0.1 9.2 6.6 0.0 2.9 2 1 0 2 2 2 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 CDI86264.1 - 0.068 13.2 0.0 1.5 8.9 0.0 2.7 3 0 0 3 3 3 0 C-terminal region of MMR_HSR1 domain AAA_22 PF13401.6 CDI86264.1 - 0.13 12.5 0.1 54 4.0 0.0 3.5 3 1 0 3 3 3 0 AAA domain DEAD PF00270.29 CDI86265.1 - 5.7e-45 153.2 0.1 7.4e-45 152.9 0.1 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 CDI86265.1 - 0.051 13.9 0.0 0.083 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Helicase_C PF00271.31 CDI86265.1 - 0.064 13.6 0.2 0.35 11.2 0.0 2.2 3 0 0 3 3 3 0 Helicase conserved C-terminal domain CMS1 PF14617.6 CDI86265.1 - 0.084 12.2 0.1 0.15 11.3 0.1 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit NUDIX PF00293.28 CDI86266.1 - 0.00025 21.1 0.0 0.00058 19.9 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain Nha1_C PF08619.10 CDI86266.1 - 0.006 15.8 2.2 0.0089 15.3 2.2 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus BRF1 PF07741.13 CDI86266.1 - 0.037 14.4 3.4 0.083 13.2 3.4 1.5 1 0 0 1 1 1 0 Brf1-like TBP-binding domain LSM PF01423.22 CDI86267.1 - 6.1e-20 70.7 0.0 7.4e-20 70.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 CDI86267.1 - 0.018 15.2 0.0 0.038 14.1 0.0 1.6 2 0 0 2 2 2 0 RimP C-terminal SH3 domain Clathrin PF00637.20 CDI86270.1 - 5.3e-173 567.8 23.0 9e-30 103.4 0.7 7.8 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 CDI86270.1 - 5.5e-28 96.7 0.2 5e-27 93.6 0.1 2.7 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.20 CDI86270.1 - 2e-09 37.3 0.0 1e-05 25.6 0.0 4.4 4 0 0 4 4 4 1 Clathrin propeller repeat Coatomer_WDAD PF04053.14 CDI86270.1 - 7e-08 31.9 1.6 0.15 11.1 0.0 3.8 3 0 0 3 3 3 3 Coatomer WD associated region TPR_17 PF13431.6 CDI86270.1 - 0.088 13.2 0.1 16 6.1 0.0 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDI86270.1 - 0.19 11.6 9.3 22 5.1 0.0 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDI86270.1 - 0.24 12.0 11.0 1.1 9.9 0.1 6.3 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDI86270.1 - 0.36 11.2 5.8 56 4.3 0.0 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDI86270.1 - 0.47 10.7 18.8 0.7 10.1 0.0 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDI86270.1 - 1.2 8.8 4.8 8.6 6.1 0.2 4.0 4 0 0 4 4 4 0 TPR repeat TPR_16 PF13432.6 CDI86270.1 - 9.2 7.0 17.0 2.2 9.0 0.2 5.9 4 1 1 5 5 5 0 Tetratricopeptide repeat Peptidase_S8 PF00082.22 CDI86272.1 - 5.4e-43 147.4 5.8 5.4e-43 147.4 5.8 1.9 2 0 0 2 2 2 1 Subtilase family LMBR1 PF04791.16 CDI86273.1 - 7.4e-08 31.7 0.0 3.6e-07 29.5 0.0 2.0 1 1 0 1 1 1 1 LMBR1-like membrane protein DUF1180 PF06679.12 CDI86273.1 - 0.0067 16.9 8.9 0.57 10.6 2.4 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF1180) CD225 PF04505.12 CDI86273.1 - 0.08 13.1 0.4 0.08 13.1 0.4 4.1 4 0 0 4 4 4 0 Interferon-induced transmembrane protein DUF2569 PF10754.9 CDI86273.1 - 0.64 10.4 7.4 0.25 11.8 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2569) Sec20 PF03908.13 CDI86274.1 - 4.8e-14 52.0 0.2 2.6e-13 49.7 0.2 2.3 1 0 0 1 1 1 1 Sec20 HupE_UreJ_2 PF13795.6 CDI86274.1 - 1.4 8.5 4.9 0.32 10.6 1.2 1.7 2 0 0 2 2 2 0 HupE / UreJ protein BLOC1_2 PF10046.9 CDI86274.1 - 6.3 7.2 8.3 3.7 7.9 0.2 3.3 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FapA PF03961.13 CDI86274.1 - 8.2 4.9 6.0 5.2 5.6 0.5 2.4 2 1 0 2 2 2 0 Flagellar Assembly Protein A ABC2_membrane PF01061.24 CDI86275.1 - 9.5e-26 90.5 6.0 1.5e-24 86.6 7.8 2.0 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 CDI86275.1 - 1.9e-21 77.0 0.1 3.2e-21 76.3 0.1 1.4 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 CDI86275.1 - 7.2e-05 22.8 0.1 0.00013 21.9 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase ABC2_membrane_3 PF12698.7 CDI86275.1 - 7.4e-05 22.0 6.3 7.4e-05 22.0 6.3 1.7 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 CDI86275.1 - 8.4e-05 22.5 0.1 0.055 13.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDI86275.1 - 0.00015 22.2 0.0 0.00032 21.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 CDI86275.1 - 0.00066 19.3 0.1 0.0012 18.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDI86275.1 - 0.00075 19.2 0.4 0.0018 17.9 0.4 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CDI86275.1 - 0.0046 17.5 0.1 0.012 16.1 0.0 1.8 2 0 0 2 2 1 1 AAA domain MMR_HSR1 PF01926.23 CDI86275.1 - 0.0076 16.3 0.6 0.014 15.4 0.6 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF87 PF01935.17 CDI86275.1 - 0.013 15.6 0.6 0.027 14.6 0.6 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain IstB_IS21 PF01695.17 CDI86275.1 - 0.02 14.6 0.1 0.064 13.0 0.1 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_28 PF13521.6 CDI86275.1 - 0.033 14.4 0.0 0.059 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDI86275.1 - 0.046 13.4 0.0 0.081 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CDI86275.1 - 0.052 12.8 0.2 0.092 12.0 0.2 1.3 1 0 0 1 1 1 0 Zeta toxin MeaB PF03308.16 CDI86275.1 - 0.052 12.5 0.3 0.11 11.4 0.3 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Rad17 PF03215.15 CDI86275.1 - 0.074 13.0 0.1 1.2 9.1 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_22 PF13401.6 CDI86275.1 - 0.17 12.1 0.1 0.46 10.8 0.1 1.8 2 1 0 2 2 1 0 AAA domain Pox_A9 PF04835.12 CDI86275.1 - 0.21 11.8 1.0 0.69 10.1 0.3 2.1 2 0 0 2 2 2 0 A9 protein conserved region Presenilin PF01080.17 CDI86278.1 - 0.00018 20.4 10.8 0.00022 20.1 10.8 1.1 1 0 0 1 1 1 1 Presenilin SseC PF04888.12 CDI86278.1 - 0.00027 20.6 18.7 0.00027 20.6 18.7 2.0 2 0 0 2 2 1 1 Secretion system effector C (SseC) like family DUF2722 PF10846.8 CDI86278.1 - 0.0016 17.4 18.9 0.0016 17.4 18.9 2.2 2 0 0 2 2 1 1 Protein of unknown function (DUF2722) SpoIIP PF07454.11 CDI86278.1 - 0.002 17.6 1.5 0.002 17.6 1.5 2.0 2 0 0 2 2 2 1 Stage II sporulation protein P (SpoIIP) FAM176 PF14851.6 CDI86278.1 - 0.0043 16.7 6.2 0.3 10.8 2.3 2.1 2 0 0 2 2 2 2 FAM176 family DUF2828 PF11443.8 CDI86278.1 - 0.0052 14.9 7.5 0.0067 14.6 7.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) DUF4834 PF16118.5 CDI86278.1 - 0.012 16.5 27.9 0.023 15.6 3.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TMEM51 PF15345.6 CDI86278.1 - 0.029 14.2 19.8 0.11 12.3 0.2 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 CLN3 PF02487.17 CDI86278.1 - 0.036 13.1 13.8 0.091 11.8 0.3 2.0 2 0 0 2 2 2 0 CLN3 protein Eapp_C PF10238.9 CDI86278.1 - 0.041 13.9 17.1 0.15 12.1 6.7 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein Ferlin_C PF16165.5 CDI86278.1 - 0.085 12.8 0.1 0.085 12.8 0.1 2.0 1 1 1 2 2 2 0 Ferlin C-terminus Glt_symporter PF03616.14 CDI86278.1 - 0.092 11.4 7.6 0.85 8.2 0.1 2.1 2 0 0 2 2 2 0 Sodium/glutamate symporter CPSF100_C PF13299.6 CDI86278.1 - 0.099 12.8 13.1 1.3 9.2 8.7 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Rxt3 PF08642.10 CDI86278.1 - 0.11 13.2 8.7 2.1 9.1 4.2 2.1 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 MecA PF05389.12 CDI86278.1 - 0.15 11.7 12.4 2.5 7.7 7.8 2.1 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF719 PF05334.13 CDI86278.1 - 0.17 12.1 11.1 2.9 8.1 6.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF719) DUF4770 PF15994.5 CDI86278.1 - 0.18 12.0 18.6 0.83 9.9 9.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Connexin PF00029.19 CDI86278.1 - 0.19 11.5 13.9 1.1 9.0 5.8 2.1 2 0 0 2 2 2 0 Connexin OATP PF03137.20 CDI86278.1 - 0.42 8.8 12.7 0.58 8.4 4.3 2.0 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family EphA2_TM PF14575.6 CDI86278.1 - 0.43 11.5 15.8 0.28 12.1 0.9 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain WBP-1 PF11669.8 CDI86278.1 - 0.46 11.1 14.1 1.3 9.6 1.9 2.3 2 0 0 2 2 2 0 WW domain-binding protein 1 7tm_1 PF00001.21 CDI86278.1 - 0.54 9.5 4.6 5.5 6.2 0.2 2.0 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) ALMT PF11744.8 CDI86278.1 - 0.63 8.8 12.3 0.2 10.5 1.5 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter GRP PF07172.11 CDI86278.1 - 0.67 10.7 7.5 1.1 10.0 0.1 2.3 2 0 0 2 2 2 0 Glycine rich protein family Conotoxin PF02950.17 CDI86278.1 - 0.87 10.6 16.8 2 9.5 2.7 2.5 2 0 0 2 2 2 0 Conotoxin FAM91_C PF14648.6 CDI86278.1 - 1 8.2 10.5 1.7 7.4 4.5 2.0 2 0 0 2 2 2 0 FAM91 C-terminus ABC2_membrane_2 PF12679.7 CDI86278.1 - 1.2 8.4 12.2 0.4 9.9 6.0 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein CPSF73-100_C PF11718.8 CDI86278.1 - 1.2 8.6 12.6 0.76 9.3 1.4 2.2 2 0 0 2 2 2 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Nucleoside_tran PF01733.18 CDI86278.1 - 1.3 8.4 11.6 0.3 10.4 0.2 2.0 1 1 1 2 2 2 0 Nucleoside transporter PRC2_HTH_1 PF18118.1 CDI86278.1 - 1.4 9.8 13.7 1.4 9.8 4.4 2.1 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain FPN1 PF06963.12 CDI86278.1 - 1.4 7.4 9.7 1.8 7.0 0.1 2.1 2 0 0 2 2 2 0 Ferroportin1 (FPN1) G0-G1_switch_2 PF15103.6 CDI86278.1 - 1.8 9.0 15.5 2.3 8.7 0.2 2.2 2 0 0 2 2 2 0 G0/G1 switch protein 2 Afi1 PF07792.12 CDI86278.1 - 1.9 9.0 18.6 5.6 7.4 2.5 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RLL PF10036.9 CDI86278.1 - 2.5 7.9 23.1 0.18 11.6 8.7 2.1 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein RXT2_N PF08595.11 CDI86278.1 - 2.6 8.1 14.9 0.076 13.0 3.8 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal AUX_IAA PF02309.16 CDI86278.1 - 2.7 7.8 10.5 4.1 7.2 10.5 1.3 1 1 0 1 1 1 0 AUX/IAA family Peptidase_S49_N PF08496.10 CDI86278.1 - 2.7 8.0 17.3 3.7 7.6 0.4 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Folate_carrier PF01770.18 CDI86278.1 - 3.7 6.2 12.3 6.3 5.4 0.5 2.2 2 0 0 2 2 2 0 Reduced folate carrier SID-1_RNA_chan PF13965.6 CDI86278.1 - 3.9 5.8 11.6 2.2 6.6 0.5 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 UPF0239 PF06783.11 CDI86278.1 - 4.3 7.6 12.7 5.8 7.2 0.2 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) CD20 PF04103.15 CDI86278.1 - 5.2 7.1 10.2 0.88 9.6 0.2 2.1 1 1 1 2 2 2 0 CD20-like family RPA43_OB PF17875.1 CDI86278.1 - 5.8 7.6 14.2 3.7 8.2 5.9 2.1 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I V_ATPase_I PF01496.19 CDI86278.1 - 6.5 4.5 21.9 0.92 7.4 1.8 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DcuC PF03606.15 CDI86278.1 - 7.6 4.9 15.7 0.1 11.0 2.0 2.0 2 0 0 2 2 2 0 C4-dicarboxylate anaerobic carrier Ndc1_Nup PF09531.10 CDI86278.1 - 7.9 5.0 18.3 11 4.6 18.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF674 PF05056.12 CDI86278.1 - 7.9 5.2 10.8 0.38 9.6 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF674) Plasmodium_Vir PF05795.11 CDI86278.1 - 8.3 5.7 7.3 11 5.3 7.3 1.3 1 1 0 1 1 1 0 Plasmodium vivax Vir protein RR_TM4-6 PF06459.12 CDI86278.1 - 8.4 6.1 18.5 6.5 6.5 9.5 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Med15 PF09606.10 CDI86278.1 - 8.8 4.9 52.1 0.022 13.5 24.5 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Renin_r PF07850.14 CDI86278.1 - 9.6 6.9 10.7 32 5.2 5.0 2.3 2 0 0 2 2 2 0 Renin receptor-like protein Band_3_cyto PF07565.13 CDI86278.1 - 9.7 5.9 20.3 1.1 9.0 7.3 2.0 2 0 0 2 2 2 0 Band 3 cytoplasmic domain RskA PF10099.9 CDI86279.1 - 1.4e-05 25.5 4.5 1.4e-05 25.5 4.5 3.6 1 1 2 3 3 3 1 Anti-sigma-K factor rskA SARAF PF06682.12 CDI86279.1 - 0.011 15.4 23.8 0.25 10.9 18.4 2.7 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4834 PF16118.5 CDI86279.1 - 0.018 16.0 6.9 0.018 16.0 6.9 3.7 2 1 2 4 4 4 0 Domain of unknown function (DUF4834) Ribosomal_60s PF00428.19 CDI86279.1 - 0.98 10.0 10.7 0.083 13.5 2.3 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF572 PF04502.13 CDI86279.1 - 3.6 7.1 38.5 6.3 6.3 38.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) CDC27 PF09507.10 CDI86279.1 - 5.6 6.2 38.6 0.3 10.4 32.8 1.7 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 RPN2_C PF18004.1 CDI86280.1 - 0.085 12.8 20.2 0.097 12.6 20.2 1.0 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4366 PF14283.6 CDI86280.1 - 0.36 10.8 13.1 0.39 10.8 13.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) FAM176 PF14851.6 CDI86280.1 - 1.1 8.9 15.9 1.3 8.7 15.9 1.1 1 0 0 1 1 1 0 FAM176 family CCDC53 PF10152.9 CDI86280.1 - 1.5 9.2 21.4 1.5 9.2 21.4 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Pex14_N PF04695.13 CDI86280.1 - 1.7 9.3 29.5 2 9.0 29.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region eIF3_subunit PF08597.10 CDI86280.1 - 1.8 8.4 23.2 2 8.2 23.2 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit RR_TM4-6 PF06459.12 CDI86280.1 - 1.9 8.2 23.7 2.1 8.1 23.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Isy1 PF06246.12 CDI86280.1 - 2.2 7.8 22.7 2.5 7.6 22.7 1.0 1 0 0 1 1 1 0 Isy1-like splicing family PIP5K PF01504.18 CDI86280.1 - 2.4 7.3 19.7 2.8 7.1 19.7 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2828 PF11443.8 CDI86280.1 - 2.7 6.0 23.6 2.8 5.9 23.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DDRGK PF09756.9 CDI86280.1 - 2.8 7.5 28.8 3.1 7.3 28.8 1.1 1 0 0 1 1 1 0 DDRGK domain FAM76 PF16046.5 CDI86280.1 - 2.9 7.2 23.4 3.3 7.0 23.4 1.1 1 0 0 1 1 1 0 FAM76 protein NARP1 PF12569.8 CDI86280.1 - 3 6.7 22.9 3.1 6.6 22.9 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 PBP1_TM PF14812.6 CDI86280.1 - 3 8.3 10.9 3.6 8.0 10.9 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF5523 PF17661.1 CDI86280.1 - 3.1 7.4 21.7 3.4 7.3 21.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) YABBY PF04690.13 CDI86280.1 - 3.5 8.2 17.1 4 8.0 17.1 1.1 1 0 0 1 1 1 0 YABBY protein CPSF100_C PF13299.6 CDI86280.1 - 3.7 7.7 19.1 4.3 7.5 19.1 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal BcsB PF03170.13 CDI86280.1 - 3.9 5.7 16.3 4.2 5.6 16.3 1.0 1 0 0 1 1 1 0 Bacterial cellulose synthase subunit Methyltransf_32 PF13679.6 CDI86280.1 - 3.9 7.4 19.6 4 7.4 19.6 1.0 1 0 0 1 1 1 0 Methyltransferase domain DUF3306 PF11748.8 CDI86280.1 - 4 8.3 18.6 4.9 8.1 18.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Afi1 PF07792.12 CDI86280.1 - 4.2 7.8 21.5 4.5 7.8 21.5 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking SpoIIP PF07454.11 CDI86280.1 - 4.3 6.7 25.1 4.6 6.6 25.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) eIF-3_zeta PF05091.12 CDI86280.1 - 4.4 6.2 28.2 5.2 5.9 28.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rtf2 PF04641.12 CDI86280.1 - 5.1 6.4 20.7 5.1 6.4 20.7 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF1387 PF07139.11 CDI86280.1 - 5.3 6.7 24.1 5.5 6.6 24.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Serinc PF03348.15 CDI86280.1 - 5.5 5.8 16.0 5.2 5.9 16.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) PPL5 PF18168.1 CDI86280.1 - 5.9 6.1 17.2 5.9 6.1 17.2 1.0 1 0 0 1 1 1 0 Prim-pol family 5 Lin-8 PF03353.15 CDI86280.1 - 6.6 6.2 30.3 7.2 6.1 30.3 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Peptidase_U57 PF05582.12 CDI86280.1 - 7.4 5.7 17.1 7.8 5.7 17.1 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Connexin PF00029.19 CDI86280.1 - 7.6 6.2 19.2 8.9 6.0 19.2 1.1 1 0 0 1 1 1 0 Connexin Gti1_Pac2 PF09729.9 CDI86280.1 - 7.8 6.5 20.8 8.5 6.4 20.8 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF913 PF06025.12 CDI86280.1 - 8.6 5.2 18.1 8.3 5.3 18.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF1764 PF08576.10 CDI86280.1 - 8.7 7.3 22.4 11 6.9 22.4 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) ALMT PF11744.8 CDI86280.1 - 8.7 5.1 20.6 8.9 5.0 20.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CobT PF06213.12 CDI86280.1 - 8.7 5.6 33.6 9.9 5.5 33.6 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4637 PF15470.6 CDI86280.1 - 8.9 6.0 14.4 12 5.6 14.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) NPR3 PF03666.13 CDI86280.1 - 9.8 4.8 23.3 11 4.7 23.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TFIIA PF03153.13 CDI86282.1 - 0.00054 20.1 49.3 0.0073 16.3 26.2 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Lactate_perm PF02652.14 CDI86282.1 - 0.059 12.1 1.0 0.081 11.6 1.0 1.1 1 0 0 1 1 1 0 L-lactate permease DUF979 PF06166.12 CDI86282.1 - 0.068 12.3 0.0 0.068 12.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF979) Ytp1 PF10355.9 CDI86282.1 - 0.36 10.0 1.2 5.9 6.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (Ytp1) Ribosomal_60s PF00428.19 CDI86283.1 - 0.0086 16.6 17.7 0.0086 16.6 17.7 5.3 5 0 0 5 5 5 2 60s Acidic ribosomal protein BAF1_ABF1 PF04684.13 CDI86283.1 - 0.01 14.9 22.4 0.063 12.3 1.1 3.4 3 0 0 3 3 3 0 BAF1 / ABF1 chromatin reorganising factor RskA PF10099.9 CDI86284.1 - 6.6e-06 26.5 29.5 0.00029 21.2 1.5 3.1 2 1 1 3 3 3 2 Anti-sigma-K factor rskA HNH_2 PF13391.6 CDI86284.1 - 0.008 16.3 0.1 3.2 8.0 0.0 2.5 2 0 0 2 2 2 2 HNH endonuclease SUIM_assoc PF16619.5 CDI86284.1 - 0.015 15.4 4.4 0.015 15.4 4.4 5.7 5 1 0 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 DUF3995 PF13160.6 CDI86284.1 - 0.87 10.0 6.2 0.71 10.2 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3995) GPCR_chapero_1 PF11904.8 CDI86284.1 - 8.1 5.8 7.6 0.93 8.9 2.3 1.9 2 0 0 2 2 2 0 GPCR-chaperone DUF2722 PF10846.8 CDI86286.1 - 0.0037 16.3 4.6 0.0037 16.3 4.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) PIP5K PF01504.18 CDI86286.1 - 0.024 13.9 1.9 0.029 13.6 1.9 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Presenilin PF01080.17 CDI86286.1 - 0.1 11.3 4.6 0.14 10.9 4.6 1.2 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CDI86286.1 - 0.61 11.1 14.8 0.24 12.4 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PilM PF07419.12 CDI86286.1 - 0.64 10.2 0.1 0.64 10.2 0.1 2.1 2 0 0 2 2 2 0 PilM KCNQ2_u3 PF16642.5 CDI86286.1 - 1.4 9.9 12.7 1.5 9.8 2.0 2.4 2 0 0 2 2 2 0 Unstructured region on Potassium channel subunit alpha KvLQT2 DUF3464 PF11947.8 CDI86286.1 - 3.6 7.3 8.9 4.7 6.9 0.7 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 eIF_4EBP PF05456.11 CDI86286.1 - 9.2 6.2 11.6 2.9 7.9 2.1 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) DUF4064 PF13273.6 CDI86287.1 - 0.042 14.1 0.0 0.059 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) K_channel_TID PF07941.11 CDI86287.1 - 0.24 11.9 8.8 0.91 10.0 2.3 2.6 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain DUF3446 PF11928.8 CDI86288.1 - 3.6 7.9 11.6 3.8 7.9 0.3 3.7 3 1 0 4 4 4 0 Early growth response N-terminal domain DUF2232 PF09991.9 CDI86289.1 - 0.45 9.7 6.3 0.72 9.0 6.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) ABC2_membrane_3 PF12698.7 CDI86289.1 - 3.1 6.8 4.9 5.1 6.1 4.9 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein Presenilin PF01080.17 CDI86290.1 - 0.089 11.5 47.4 0.11 11.3 47.4 1.0 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI86290.1 - 2.3 7.1 43.7 2.5 7.0 43.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF5427 PF10310.9 CDI86290.1 - 3.7 6.4 39.7 6 5.7 39.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF4045 PF13254.6 CDI86290.1 - 3.8 7.1 36.8 4.4 6.8 36.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF572 PF04502.13 CDI86290.1 - 4.4 6.8 34.3 5.1 6.6 34.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) CDC45 PF02724.14 CDI86290.1 - 5.9 5.1 37.4 7 4.8 37.4 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.6 CDI86290.1 - 6.4 6.7 35.9 9 6.2 35.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF2052 PF09747.9 CDI86290.1 - 7.9 6.6 38.8 12 6.0 38.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Ribosomal_60s PF00428.19 CDI86292.1 - 0.00041 20.9 10.6 0.00041 20.9 10.6 16.5 9 4 3 12 12 12 3 60s Acidic ribosomal protein SR-25 PF10500.9 CDI86293.1 - 0.00045 19.9 25.6 0.00066 19.4 25.6 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CCSAP PF15748.5 CDI86293.1 - 0.16 12.1 32.0 0.18 11.9 32.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated RR_TM4-6 PF06459.12 CDI86293.1 - 0.64 9.8 27.5 0.7 9.7 27.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TCP PF03634.13 CDI86293.1 - 4.1 8.0 33.6 5.1 7.6 33.6 1.1 1 0 0 1 1 1 0 TCP family transcription factor Endostatin PF06482.11 CDI86293.1 - 5.7 6.3 27.5 6.2 6.2 27.5 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF913 PF06025.12 CDI86293.1 - 7.5 5.4 18.8 11 4.9 18.8 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CR6_interact PF10147.9 CDI86294.1 - 0.016 14.9 0.9 0.03 14.1 0.9 1.3 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF4316 PF14195.6 CDI86294.1 - 0.19 11.5 1.0 0.85 9.4 1.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4316) Ank_2 PF12796.7 CDI86295.1 - 3.6e-23 81.9 2.1 1.6e-12 47.9 0.1 4.1 3 1 2 5 5 5 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI86295.1 - 3.1e-15 56.3 1.5 1.8e-10 41.1 0.0 4.5 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI86295.1 - 3.2e-12 45.5 6.5 6.2e-06 26.2 0.0 6.3 6 0 0 6 6 6 2 Ankyrin repeat Ank PF00023.30 CDI86295.1 - 7.2e-12 45.2 6.6 3.1e-05 24.2 0.1 5.4 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 CDI86295.1 - 3.6e-09 36.7 4.6 2.6e-07 30.8 0.2 4.6 4 1 1 5 5 5 2 Ankyrin repeats (many copies) SET PF00856.28 CDI86295.1 - 0.00023 21.6 0.0 0.00077 19.9 0.0 2.1 1 1 0 1 1 1 1 SET domain DUF4407 PF14362.6 CDI86300.1 - 0.012 15.0 20.2 0.013 14.9 20.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SpoIIP PF07454.11 CDI86300.1 - 0.12 11.8 24.7 0.14 11.6 24.7 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Pex14_N PF04695.13 CDI86300.1 - 0.25 12.0 38.5 0.29 11.8 38.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region BORG_CEP PF14957.6 CDI86300.1 - 0.28 12.4 18.7 0.34 12.1 18.7 1.0 1 0 0 1 1 1 0 Cdc42 effector DUF913 PF06025.12 CDI86300.1 - 0.36 9.8 14.6 0.37 9.7 14.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 CDI86300.1 - 0.36 10.6 24.9 0.37 10.6 24.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.8 CDI86300.1 - 0.43 9.3 22.2 0.5 9.1 22.2 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF3295 PF11702.8 CDI86300.1 - 0.46 9.8 23.2 0.5 9.7 23.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DUF5427 PF10310.9 CDI86300.1 - 0.52 9.2 25.8 0.59 9.0 25.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) CCSAP PF15748.5 CDI86300.1 - 0.75 9.9 27.7 0.79 9.8 27.7 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Peptidase_U57 PF05582.12 CDI86300.1 - 0.89 8.7 16.1 1 8.6 16.1 1.1 1 0 0 1 1 1 0 YabG peptidase U57 CPSF100_C PF13299.6 CDI86300.1 - 0.99 9.6 18.7 1.3 9.2 18.7 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 CDI86300.1 - 0.99 8.1 31.1 1.1 8.0 31.1 1.0 1 0 0 1 1 1 0 Presenilin Endostatin PF06482.11 CDI86300.1 - 0.99 8.8 23.8 1.1 8.7 23.8 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin VIR_N PF15912.5 CDI86300.1 - 1 8.9 13.7 1.1 8.8 13.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DUF4746 PF15928.5 CDI86300.1 - 1.1 8.7 16.4 1.2 8.5 16.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FAM60A PF15396.6 CDI86300.1 - 1.2 9.1 19.2 1.4 8.9 19.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A NPR3 PF03666.13 CDI86300.1 - 1.2 7.8 24.0 1.4 7.7 24.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DDHD PF02862.17 CDI86300.1 - 1.4 9.1 21.1 1.8 8.7 21.1 1.2 1 0 0 1 1 1 0 DDHD domain Cellulose_synt PF03552.14 CDI86300.1 - 1.7 7.0 9.0 1.8 6.9 9.0 1.0 1 0 0 1 1 1 0 Cellulose synthase CCDC53 PF10152.9 CDI86300.1 - 1.7 9.0 26.4 2.2 8.7 26.4 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex PAT1 PF09770.9 CDI86300.1 - 1.9 6.6 41.2 2.1 6.5 41.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 CDI86300.1 - 2 7.3 25.1 2.3 7.2 25.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 FAM176 PF14851.6 CDI86300.1 - 2.1 8.0 17.2 2.9 7.6 17.2 1.2 1 0 0 1 1 1 0 FAM176 family DUF2072 PF09845.9 CDI86300.1 - 2.1 8.6 16.1 2.7 8.3 16.1 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein Rtf2 PF04641.12 CDI86300.1 - 2.3 7.5 22.7 2.8 7.2 22.7 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger eIF-3_zeta PF05091.12 CDI86300.1 - 2.4 7.1 34.1 2.7 6.9 34.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_S64 PF08192.11 CDI86300.1 - 2.5 6.5 23.6 2.9 6.3 23.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 Baculo_PP31 PF05311.11 CDI86300.1 - 2.7 7.4 23.5 3 7.2 23.5 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) NARP1 PF12569.8 CDI86300.1 - 2.7 6.8 24.1 3.1 6.6 24.1 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Peptidase_S15 PF02129.18 CDI86300.1 - 4 6.9 18.8 4.5 6.8 18.8 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF2828 PF11443.8 CDI86300.1 - 4 5.4 25.2 4.5 5.2 25.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CDC45 PF02724.14 CDI86300.1 - 4.9 5.3 24.8 5.3 5.2 24.8 1.0 1 0 0 1 1 1 0 CDC45-like protein MCM_bind PF09739.9 CDI86300.1 - 5.9 5.2 22.8 6.7 5.0 22.8 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor PA26 PF04636.13 CDI86300.1 - 6.2 5.6 18.4 6.8 5.5 18.4 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SAPS PF04499.15 CDI86300.1 - 6.3 5.5 19.2 7.2 5.3 19.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2464 PF10240.9 CDI86300.1 - 6.9 6.2 16.3 7.8 6.0 16.3 1.2 1 0 0 1 1 1 0 Multivesicular body subunit 12 Asp-B-Hydro_N PF05279.11 CDI86300.1 - 7 6.6 17.2 7.6 6.5 17.2 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Hid1 PF12722.7 CDI86300.1 - 7.6 4.5 24.2 8.4 4.4 24.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CobT PF06213.12 CDI86300.1 - 7.8 5.8 37.6 9.6 5.5 37.6 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Paf1 PF03985.13 CDI86300.1 - 8.1 5.3 29.3 9.7 5.1 29.3 1.0 1 0 0 1 1 1 0 Paf1 PTPRCAP PF15713.5 CDI86300.1 - 8.5 6.7 26.9 10 6.4 26.9 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF4661 PF15576.6 CDI86300.1 - 8.9 6.1 8.8 9.7 6.0 8.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) DUF1387 PF07139.11 CDI86300.1 - 8.9 5.9 25.3 10 5.7 25.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Plasmodium_Vir PF05795.11 CDI86300.1 - 9.3 5.6 15.0 9.7 5.5 15.0 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SPX PF03105.19 CDI86302.1 - 0.041 13.8 8.0 0.048 13.6 8.0 1.3 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI86302.1 - 0.17 10.7 5.7 0.2 10.5 5.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain HSD3 PF15244.6 CDI86302.1 - 1 8.8 9.8 1.5 8.3 9.8 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 AF-4 PF05110.13 CDI86302.1 - 2.7 6.0 14.0 3.3 5.7 14.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4614 PF15391.6 CDI86302.1 - 9.2 6.2 23.7 0.14 12.2 16.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) LZ3wCH PF18517.1 CDI86303.1 - 0.00015 21.8 0.1 0.00026 21.0 0.0 1.5 2 0 0 2 2 2 1 Leucine zipper with capping helix domain DUF737 PF05300.11 CDI86304.1 - 0.00059 20.3 11.4 0.00059 20.3 11.4 14.9 8 3 1 9 9 9 1 Protein of unknown function (DUF737) RskA PF10099.9 CDI86304.1 - 0.0016 18.7 0.0 0.0016 18.7 0.0 21.6 11 7 8 19 19 19 6 Anti-sigma-K factor rskA Kinase-like PF14531.6 CDI86306.1 - 0.00065 19.1 0.0 0.00091 18.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.25 CDI86306.1 - 0.0017 17.8 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Mpp10 PF04006.12 CDI86307.1 - 2.1e-13 49.6 176.2 5.1e-07 28.5 0.0 4.9 2 1 1 4 4 4 3 Mpp10 protein RskA PF10099.9 CDI86307.1 - 0.0062 16.9 2.8 0.0062 16.9 2.8 9.7 2 2 4 6 6 6 1 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI86308.1 - 0.00018 20.4 27.6 0.00022 20.1 27.6 1.2 1 0 0 1 1 1 1 Presenilin PNISR PF15996.5 CDI86308.1 - 0.0013 19.0 29.7 0.0017 18.7 29.7 1.3 1 0 0 1 1 1 1 Arginine/serine-rich protein PNISR Lin-8 PF03353.15 CDI86308.1 - 0.0049 16.5 27.6 0.0063 16.1 27.6 1.2 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist DUF4045 PF13254.6 CDI86308.1 - 0.034 13.8 21.6 0.042 13.5 21.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) FAM60A PF15396.6 CDI86308.1 - 0.049 13.6 21.7 0.08 12.9 21.7 1.3 1 0 0 1 1 1 0 Protein Family FAM60A AF-4 PF05110.13 CDI86308.1 - 0.051 11.7 34.4 0.058 11.5 34.4 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PAT1 PF09770.9 CDI86308.1 - 0.11 10.7 47.0 0.14 10.4 47.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF572 PF04502.13 CDI86308.1 - 0.65 9.6 27.1 1 8.9 27.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) CCSAP PF15748.5 CDI86308.1 - 1 9.5 37.2 1.8 8.7 37.2 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Draxin PF15550.6 CDI86308.1 - 1.7 8.5 23.0 2.3 8.0 23.0 1.1 1 0 0 1 1 1 0 Draxin DUF4820 PF16091.5 CDI86308.1 - 1.9 7.8 29.0 3.1 7.1 29.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Smg8_Smg9 PF10220.9 CDI86308.1 - 2 6.7 31.2 2.5 6.3 31.2 1.0 1 0 0 1 1 1 0 Smg8_Smg9 SLC12 PF03522.15 CDI86308.1 - 2 7.3 33.6 2.9 6.8 33.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 MID_MedPIWI PF18296.1 CDI86308.1 - 5.4 6.7 29.6 9.7 5.9 29.6 1.4 1 0 0 1 1 1 0 MID domain of medPIWI Caldesmon PF02029.15 CDI86308.1 - 6.4 5.4 36.3 8.2 5.1 36.3 1.1 1 0 0 1 1 1 0 Caldesmon LMBR1 PF04791.16 CDI86308.1 - 6.6 5.5 18.8 8.3 5.2 18.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein PPP4R2 PF09184.11 CDI86308.1 - 7 6.2 21.8 9.5 5.7 21.8 1.1 1 0 0 1 1 1 0 PPP4R2 Ndc1_Nup PF09531.10 CDI86308.1 - 7.5 5.1 32.0 9.1 4.8 32.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ALMT PF11744.8 CDI86308.1 - 8 5.2 28.3 12 4.6 28.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter RskA PF10099.9 CDI86309.1 - 0.48 10.7 32.0 4.1 7.7 0.1 2.5 2 1 0 2 2 2 0 Anti-sigma-K factor rskA Pol_alpha_B_N PF08418.10 CDI86309.1 - 0.66 9.9 7.6 3.6 7.5 0.2 2.3 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal TFIIA PF03153.13 CDI86309.1 - 1.5 8.7 16.5 3.3 7.6 16.3 1.6 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit INSIG PF07281.12 CDI86311.1 - 0.0016 18.2 0.6 0.066 12.9 0.0 2.1 2 0 0 2 2 2 1 Insulin-induced protein (INSIG) DUF4834 PF16118.5 CDI86311.1 - 0.0016 19.4 5.7 0.083 13.9 0.3 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) MAS20 PF02064.15 CDI86311.1 - 0.016 15.3 10.6 0.69 10.0 0.7 2.3 2 0 0 2 2 2 0 MAS20 protein import receptor SUIM_assoc PF16619.5 CDI86311.1 - 0.027 14.5 11.7 0.027 14.5 11.7 3.3 3 1 0 3 3 1 0 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI86311.1 - 0.069 13.4 30.1 0.11 12.7 8.1 2.6 1 1 0 2 2 2 0 Anti-sigma-K factor rskA DUF5408 PF17402.2 CDI86311.1 - 0.097 12.6 0.2 0.25 11.3 0.2 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5408) G0-G1_switch_2 PF15103.6 CDI86311.1 - 0.15 12.5 8.5 0.23 11.9 0.8 2.5 3 0 0 3 3 2 0 G0/G1 switch protein 2 GIDA_assoc PF13932.6 CDI86311.1 - 0.28 11.3 9.3 0.71 10.0 3.8 2.1 2 0 0 2 2 2 0 GidA associated domain UPF0093 PF03653.13 CDI86311.1 - 0.39 10.9 1.8 0.97 9.7 0.1 2.1 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0093) BBS2_N PF14781.6 CDI86311.1 - 0.42 10.5 2.9 2.2 8.2 0.2 2.3 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal DUF1682 PF07946.14 CDI86311.1 - 0.46 9.6 9.2 0.034 13.4 1.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) DUF1840 PF08895.11 CDI86311.1 - 0.47 10.8 19.2 0.48 10.8 6.8 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) NifQ PF04891.12 CDI86311.1 - 0.5 10.7 10.2 3.7 7.9 3.3 2.3 2 0 0 2 2 2 0 NifQ DUF2973 PF11189.8 CDI86311.1 - 0.52 10.4 2.8 2.3 8.4 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) 2HCT PF03390.15 CDI86311.1 - 0.55 8.8 1.7 1.3 7.6 0.2 1.9 1 1 1 2 2 2 0 2-hydroxycarboxylate transporter family MMM1 PF10296.9 CDI86311.1 - 0.67 8.9 5.2 1.6 7.7 0.1 2.1 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 CrgA PF06781.12 CDI86311.1 - 0.8 9.8 2.3 10 6.3 0.0 2.4 2 0 0 2 2 2 0 Cell division protein CrgA DUF3729 PF12526.8 CDI86311.1 - 0.85 11.2 4.7 1.2 10.8 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3729) DUF702 PF05142.12 CDI86311.1 - 1.1 9.7 13.1 3.8 8.0 5.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Orf78 PF06024.12 CDI86311.1 - 1.3 9.3 3.7 5.4 7.4 0.1 2.4 2 0 0 2 2 2 0 Orf78 (ac78) Baculo_PP31 PF05311.11 CDI86311.1 - 1.3 8.4 9.3 0.75 9.2 2.2 2.1 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) TERB2 PF15101.6 CDI86311.1 - 1.6 8.8 14.4 2 8.4 2.2 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Spore_coat_CotO PF14153.6 CDI86311.1 - 1.7 8.5 17.7 3.7 7.4 4.2 2.2 2 0 0 2 2 2 0 Spore coat protein CotO Androgen_recep PF02166.16 CDI86311.1 - 5.2 5.8 37.2 1.2 7.9 11.0 2.2 2 0 0 2 2 2 0 Androgen receptor AIF_C PF14721.6 CDI86311.1 - 5.4 7.4 8.9 16 5.8 0.2 2.4 3 0 0 3 3 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4578 PF15147.6 CDI86311.1 - 7 7.5 17.9 8.9 7.2 5.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) CbiD PF01888.17 CDI86311.1 - 8.4 5.6 9.3 0.83 8.9 2.5 2.2 2 1 0 2 2 2 0 CbiD Med3 PF11593.8 CDI86311.1 - 9.3 5.3 40.5 0.42 9.8 15.8 2.1 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal SR-25 PF10500.9 CDI86312.1 - 0.0017 18.1 25.1 0.0017 18.1 25.1 4.2 2 2 0 4 4 4 1 Nuclear RNA-splicing-associated protein Caldesmon PF02029.15 CDI86312.1 - 0.028 13.2 71.5 0.18 10.6 23.1 2.2 2 0 0 2 2 2 0 Caldesmon DUF4776 PF16003.5 CDI86312.1 - 1.9 7.4 49.3 0.08 11.9 20.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) ABC_export PF16962.5 CDI86312.1 - 6.8 5.0 6.8 9.6 4.5 6.8 1.1 1 0 0 1 1 1 0 Putative ABC exporter Cwf_Cwc_15 PF04889.12 CDI86312.1 - 7.5 6.2 73.8 1.4 8.6 17.1 3.2 2 1 1 3 3 3 0 Cwf15/Cwc15 cell cycle control protein Sigma70_ner PF04546.13 CDI86312.1 - 8.4 6.2 48.8 0.16 11.9 10.7 3.3 3 0 0 3 3 3 0 Sigma-70, non-essential region PPP4R2 PF09184.11 CDI86312.1 - 8.6 5.9 62.1 0.051 13.2 28.8 2.2 2 0 0 2 2 2 0 PPP4R2 SR-25 PF10500.9 CDI86313.1 - 4 7.0 16.0 4.6 6.8 16.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CCDC24 PF15669.5 CDI86313.1 - 9 6.1 10.0 9.8 6.0 10.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family DUF2052 PF09747.9 CDI86314.1 - 1.2 9.3 30.5 1.7 8.8 30.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Presenilin PF01080.17 CDI86314.1 - 6.6 5.4 41.1 7.5 5.2 41.1 1.1 1 0 0 1 1 1 0 Presenilin Raftlin PF15250.6 CDI86314.1 - 7.8 5.1 30.2 8.4 5.0 30.2 1.0 1 0 0 1 1 1 0 Raftlin Kinesin PF00225.23 CDI86315.1 - 1.2e-39 136.2 0.2 1.2e-39 136.2 0.2 1.3 2 0 0 2 2 2 1 Kinesin motor domain O-antigen_lig PF13425.6 CDI86317.1 - 0.0034 16.2 10.1 0.0034 16.2 10.1 1.9 1 1 1 2 2 2 1 O-antigen ligase like membrane protein DUF588 PF04535.12 CDI86317.1 - 0.041 13.7 0.1 0.057 13.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF588) SLC12 PF03522.15 CDI86317.1 - 4 6.4 43.1 5.3 5.9 43.1 1.4 1 0 0 1 1 1 0 Solute carrier family 12 SPX PF03105.19 CDI86317.1 - 6.3 6.6 37.2 7.9 6.3 37.2 1.3 1 0 0 1 1 1 0 SPX domain Mucin PF01456.17 CDI86318.1 - 0.0044 17.0 4.6 0.0044 17.0 4.6 3.2 3 1 0 3 3 3 1 Mucin-like glycoprotein Pkinase PF00069.25 CDI86319.1 - 2.1e-46 158.4 6.7 6.8e-30 104.3 0.0 3.2 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI86319.1 - 2.1e-23 82.9 6.6 8.9e-14 51.4 0.0 3.2 2 1 1 3 3 3 2 Protein tyrosine kinase SR-25 PF10500.9 CDI86319.1 - 0.0064 16.1 13.8 0.0064 16.1 13.8 3.7 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein Haspin_kinase PF12330.8 CDI86319.1 - 0.39 9.6 0.0 0.39 9.6 0.0 3.5 3 1 1 4 4 4 0 Haspin like kinase domain Pro_CA PF00484.19 CDI86319.1 - 0.51 10.6 3.3 1.7 8.9 3.3 2.0 1 0 0 1 1 1 0 Carbonic anhydrase DUF572 PF04502.13 CDI86319.1 - 4.4 6.8 26.9 3.9 7.0 9.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) DAGAT PF03982.13 CDI86320.1 - 1.4e-24 86.5 0.1 1.2e-23 83.4 0.0 2.0 2 0 0 2 2 2 1 Diacylglycerol acyltransferase L51_S25_CI-B8 PF05047.16 CDI86321.1 - 6e-06 26.1 0.0 1.1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain ABC_tran PF00005.27 CDI86322.1 - 3.7e-33 114.9 0.0 7.9e-33 113.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDI86322.1 - 1.2e-22 80.9 7.0 2.2e-22 80.0 7.0 1.4 1 1 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.6 CDI86322.1 - 0.00037 20.4 0.1 0.005 16.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDI86322.1 - 0.0006 19.3 0.0 0.033 13.6 0.0 2.1 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDI86322.1 - 0.0018 18.7 0.2 0.0018 18.7 0.2 3.0 3 1 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.6 CDI86322.1 - 0.0051 17.1 0.0 0.037 14.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CDI86322.1 - 0.011 15.0 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_29 PF13555.6 CDI86322.1 - 0.016 14.9 0.1 0.043 13.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.13 CDI86322.1 - 0.021 14.0 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.12 CDI86322.1 - 0.055 13.4 0.1 0.18 11.7 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 CDI86322.1 - 0.057 13.0 1.2 0.41 10.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CDI86322.1 - 0.06 13.4 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 CDI86322.1 - 0.076 12.7 0.0 0.19 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CDI86322.1 - 0.12 12.8 0.0 1 9.8 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CDI86322.1 - 0.14 12.0 0.1 0.33 10.9 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 CDI86322.1 - 0.16 12.1 0.0 0.39 10.8 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF1385 PF07136.11 CDI86322.1 - 0.24 10.7 1.5 1.5 8.1 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1385) AAA_15 PF13175.6 CDI86322.1 - 0.25 11.0 0.0 0.37 10.5 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Pox_A32 PF04665.12 CDI86322.1 - 0.26 10.7 0.0 0.48 9.8 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein SseC PF04888.12 CDI86322.1 - 0.28 10.7 8.7 0.51 9.9 8.7 1.4 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DLIC PF05783.11 CDI86322.1 - 0.87 8.3 2.9 0.39 9.5 0.0 1.8 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) Ribosomal_60s PF00428.19 CDI86322.1 - 3.8 8.2 11.4 11 6.7 11.4 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein Surface_antigen PF11054.8 CDI86323.1 - 5.9e-77 258.6 3.8 1.4e-74 250.9 3.8 2.0 1 1 0 1 1 1 1 Sporozoite TA4 surface antigen Phage_TTP_13 PF16463.5 CDI86323.1 - 0.00056 19.4 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 Phage tail tube protein family GCD14 PF08704.10 CDI86324.1 - 8.7e-64 215.5 0.0 3.2e-40 138.4 0.0 2.2 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 CDI86324.1 - 0.00025 20.9 0.0 0.25 11.2 0.0 2.6 3 0 0 3 3 3 2 Methyltransferase domain PCMT PF01135.19 CDI86324.1 - 0.017 14.9 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Surface_antigen PF11054.8 CDI86325.1 - 2.2e-73 246.9 4.1 2.7e-73 246.6 4.1 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen DUF3761 PF12587.8 CDI86325.1 - 0.076 13.4 0.1 0.89 10.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3761) Surface_antigen PF11054.8 CDI86326.1 - 3e-156 518.3 17.7 3.5e-79 265.9 3.3 3.0 2 1 1 3 3 3 3 Sporozoite TA4 surface antigen Surface_antigen PF11054.8 CDI86327.1 - 1.4e-80 270.5 7.0 1.6e-80 270.3 7.0 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen Surface_antigen PF11054.8 CDI86328.1 - 9.2e-33 113.9 1.9 1e-32 113.7 1.9 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen TRAP_alpha PF03896.16 CDI86331.1 - 0.00013 21.3 5.1 0.00014 21.2 5.1 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.6 CDI86331.1 - 0.00039 20.1 4.9 0.00049 19.8 4.9 1.2 1 0 0 1 1 1 1 FAM176 family DUF4770 PF15994.5 CDI86331.1 - 0.00041 20.6 15.0 0.00064 20.0 15.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4770) V_ATPase_I PF01496.19 CDI86331.1 - 0.00067 17.7 13.8 0.00073 17.6 13.8 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family MMM1 PF10296.9 CDI86331.1 - 0.0009 18.4 6.0 0.0011 18.1 6.0 1.0 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 Connexin PF00029.19 CDI86331.1 - 0.00099 18.9 7.9 0.0011 18.8 7.9 1.1 1 0 0 1 1 1 1 Connexin O-antigen_lig PF13425.6 CDI86331.1 - 0.0011 17.8 7.4 0.0013 17.6 7.4 1.0 1 0 0 1 1 1 1 O-antigen ligase like membrane protein CLN3 PF02487.17 CDI86331.1 - 0.0012 18.0 10.1 0.0013 17.9 10.1 1.0 1 0 0 1 1 1 1 CLN3 protein SpoIIP PF07454.11 CDI86331.1 - 0.0013 18.3 16.9 0.0014 18.1 16.9 1.0 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) MID_MedPIWI PF18296.1 CDI86331.1 - 0.0015 18.4 10.1 0.0015 18.3 10.1 1.0 1 0 0 1 1 1 1 MID domain of medPIWI CSG2 PF16965.5 CDI86331.1 - 0.0018 17.3 6.7 0.0019 17.2 6.7 1.0 1 0 0 1 1 1 1 Ceramide synthase regulator Presenilin PF01080.17 CDI86331.1 - 0.002 17.0 15.0 0.0021 16.9 15.0 1.1 1 0 0 1 1 1 1 Presenilin SID-1_RNA_chan PF13965.6 CDI86331.1 - 0.0023 16.5 5.5 0.0024 16.4 5.5 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 RNA_pol_Rpc4 PF05132.14 CDI86331.1 - 0.0032 17.9 12.5 0.0036 17.8 12.5 1.0 1 0 0 1 1 1 1 RNA polymerase III RPC4 Ctr PF04145.15 CDI86331.1 - 0.0052 17.4 5.3 0.0058 17.3 5.3 1.1 1 0 0 1 1 1 1 Ctr copper transporter family PIP5K PF01504.18 CDI86331.1 - 0.0054 16.0 10.2 0.0054 16.0 10.2 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase CobT PF06213.12 CDI86331.1 - 0.0054 16.1 24.2 0.0063 15.9 24.2 1.0 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT OATP PF03137.20 CDI86331.1 - 0.0063 14.9 6.0 0.007 14.7 6.0 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF2828 PF11443.8 CDI86331.1 - 0.0068 14.6 11.9 0.0071 14.5 11.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) Spore_III_AF PF09581.10 CDI86331.1 - 0.0069 16.4 13.6 0.011 15.8 13.6 1.3 1 0 0 1 1 1 1 Stage III sporulation protein AF (Spore_III_AF) BIRC6 PF12356.8 CDI86331.1 - 0.011 15.2 3.2 0.011 15.2 3.2 1.0 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 Zip PF02535.22 CDI86331.1 - 0.011 15.0 3.4 0.013 14.8 3.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SARAF PF06682.12 CDI86331.1 - 0.013 15.1 11.6 0.017 14.8 11.6 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Pinin_SDK_memA PF04696.13 CDI86331.1 - 0.014 15.5 28.2 0.016 15.3 28.2 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region HSNSD PF12062.8 CDI86331.1 - 0.015 14.1 5.7 0.015 14.0 5.7 1.0 1 0 0 1 1 1 0 heparan sulfate-N-deacetylase Peptidase_M56 PF05569.11 CDI86331.1 - 0.017 14.4 1.9 0.02 14.1 1.9 1.0 1 0 0 1 1 1 0 BlaR1 peptidase M56 Nucleoside_tran PF01733.18 CDI86331.1 - 0.02 14.3 4.7 0.022 14.2 4.7 1.0 1 0 0 1 1 1 0 Nucleoside transporter DUF4446 PF14584.6 CDI86331.1 - 0.021 14.8 5.4 0.022 14.8 5.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) PSK PF06404.12 CDI86331.1 - 0.024 15.7 11.3 0.031 15.3 11.3 1.1 1 0 0 1 1 1 0 Phytosulfokine precursor protein (PSK) Serinc PF03348.15 CDI86331.1 - 0.024 13.6 7.0 0.029 13.3 7.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Gastrin PF00918.17 CDI86331.1 - 0.025 15.5 8.9 0.028 15.4 8.9 1.1 1 0 0 1 1 1 0 Gastrin/cholecystokinin family Folate_carrier PF01770.18 CDI86331.1 - 0.025 13.3 7.0 0.026 13.3 7.0 1.0 1 0 0 1 1 1 0 Reduced folate carrier DUF5308 PF17233.2 CDI86331.1 - 0.027 14.7 12.5 0.03 14.6 12.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Usp PF00582.26 CDI86331.1 - 0.031 14.8 0.4 0.039 14.5 0.4 1.2 1 0 0 1 1 1 0 Universal stress protein family CBP_BcsG PF11658.8 CDI86331.1 - 0.031 12.7 10.7 0.036 12.5 10.7 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Baculo_PP31 PF05311.11 CDI86331.1 - 0.039 13.4 11.5 0.041 13.4 11.5 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF3394 PF11874.8 CDI86331.1 - 0.041 13.6 4.1 0.048 13.3 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) EOS1 PF12326.8 CDI86331.1 - 0.046 13.7 5.4 0.048 13.6 5.4 1.2 1 0 0 1 1 1 0 N-glycosylation protein Scs3p PF10261.9 CDI86331.1 - 0.05 13.1 3.5 0.056 12.9 3.5 1.0 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM CPSF100_C PF13299.6 CDI86331.1 - 0.052 13.7 14.2 0.057 13.6 14.2 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Tmemb_9 PF05434.11 CDI86331.1 - 0.053 13.4 17.2 0.063 13.2 17.2 1.1 1 0 0 1 1 1 0 TMEM9 PRC2_HTH_1 PF18118.1 CDI86331.1 - 0.055 14.3 10.6 0.069 14.0 10.6 1.2 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Ureide_permease PF07168.11 CDI86331.1 - 0.057 12.2 4.5 0.06 12.1 4.5 1.1 1 0 0 1 1 1 0 Ureide permease RIC3 PF15361.6 CDI86331.1 - 0.066 13.6 10.9 0.084 13.3 10.9 1.1 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Tim54 PF11711.8 CDI86331.1 - 0.074 11.8 18.7 0.087 11.6 18.7 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Afi1 PF07792.12 CDI86331.1 - 0.1 13.1 15.0 0.12 12.8 15.0 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CCDC53 PF10152.9 CDI86331.1 - 0.11 12.9 18.0 0.14 12.6 18.0 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF5523 PF17661.1 CDI86331.1 - 0.13 11.9 20.7 0.15 11.7 20.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF4820 PF16091.5 CDI86331.1 - 0.13 11.6 11.1 0.19 11.1 11.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Pex24p PF06398.11 CDI86331.1 - 0.14 11.1 2.7 0.25 10.3 2.7 1.5 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF3402 PF11882.8 CDI86331.1 - 0.19 10.8 14.4 0.23 10.5 14.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) EFTUD2 PF16004.5 CDI86331.1 - 0.2 12.2 20.1 0.24 12.0 20.1 1.0 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus DUF1180 PF06679.12 CDI86331.1 - 0.24 11.8 5.3 0.29 11.6 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF913 PF06025.12 CDI86331.1 - 0.25 10.3 11.6 0.27 10.2 11.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) MCD PF05292.11 CDI86331.1 - 0.27 10.8 9.7 0.32 10.5 9.7 1.0 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain Cadherin_C_2 PF16492.5 CDI86331.1 - 0.28 11.9 2.4 0.42 11.4 2.4 1.3 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Pannexin_like PF12534.8 CDI86331.1 - 0.33 10.0 10.9 0.34 9.9 10.9 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 YABBY PF04690.13 CDI86331.1 - 0.34 11.5 13.5 0.39 11.3 13.5 1.0 1 0 0 1 1 1 0 YABBY protein RICTOR_N PF14664.6 CDI86331.1 - 0.35 9.8 5.6 0.43 9.5 5.6 1.2 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term BORG_CEP PF14957.6 CDI86331.1 - 0.39 11.9 13.2 0.48 11.6 13.2 1.1 1 0 0 1 1 1 0 Cdc42 effector SLC12 PF03522.15 CDI86331.1 - 0.41 9.6 17.0 0.44 9.5 17.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 HCO3_cotransp PF00955.21 CDI86331.1 - 0.43 9.4 6.0 0.43 9.4 6.0 1.1 1 0 0 1 1 1 0 HCO3- transporter family ETRAMP PF09716.10 CDI86331.1 - 0.43 10.7 2.5 1.2 9.3 2.5 1.7 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Tmem26 PF09772.9 CDI86331.1 - 0.44 9.9 5.5 0.46 9.8 5.5 1.1 1 0 0 1 1 1 0 Transmembrane protein 26 Acatn PF13000.7 CDI86331.1 - 0.48 8.9 2.2 0.48 8.9 2.2 1.1 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 Stig1 PF04885.13 CDI86331.1 - 0.54 10.7 11.4 0.64 10.5 11.4 1.1 1 0 0 1 1 1 0 Stigma-specific protein, Stig1 HemX PF04375.14 CDI86331.1 - 0.55 9.5 30.9 0.59 9.4 30.9 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2946 PF11162.8 CDI86331.1 - 0.55 10.9 4.1 0.84 10.3 4.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2946) Band_3_cyto PF07565.13 CDI86331.1 - 0.56 10.0 16.3 0.63 9.8 16.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Conotoxin PF02950.17 CDI86331.1 - 0.6 11.2 17.3 55 4.9 17.3 2.1 1 1 0 1 1 1 0 Conotoxin DcuA_DcuB PF03605.14 CDI86331.1 - 0.69 8.7 3.2 0.75 8.6 3.2 1.3 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF4366 PF14283.6 CDI86331.1 - 0.7 9.9 10.9 0.78 9.8 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) LETM1 PF07766.13 CDI86331.1 - 0.73 9.1 13.3 0.84 8.9 13.3 1.0 1 0 0 1 1 1 0 LETM1-like protein DDHD PF02862.17 CDI86331.1 - 0.77 9.9 16.9 0.92 9.6 16.9 1.1 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 CDI86331.1 - 0.8 9.7 13.2 0.93 9.5 13.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF443 PF04276.12 CDI86331.1 - 0.81 9.5 4.5 0.19 11.5 0.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF443) Pap_E4 PF02711.14 CDI86331.1 - 0.82 10.7 15.7 1 10.4 15.7 1.1 1 0 0 1 1 1 0 E4 protein DUF2370 PF10176.9 CDI86331.1 - 0.82 9.3 8.2 0.85 9.2 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Sugar_tr PF00083.24 CDI86331.1 - 0.87 8.4 2.3 0.95 8.3 2.3 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter Tmp39 PF10271.9 CDI86331.1 - 1 8.3 5.1 1.1 8.1 5.1 1.0 1 0 0 1 1 1 0 Putative transmembrane protein DUF4228 PF14009.6 CDI86331.1 - 1.1 9.7 8.0 1.3 9.4 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Mem_trans PF03547.18 CDI86331.1 - 1.1 7.6 4.7 1.2 7.5 4.7 1.1 1 0 0 1 1 1 0 Membrane transport protein T2SSC PF11356.8 CDI86331.1 - 1.1 9.2 10.4 1.6 8.7 10.4 1.2 1 0 0 1 1 1 0 Type II secretion system protein C PBP1_TM PF14812.6 CDI86331.1 - 1.1 9.6 9.2 1.7 9.1 9.2 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2126 PF09899.9 CDI86331.1 - 1.2 7.1 15.6 1.3 7.0 15.6 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Otopetrin PF03189.13 CDI86331.1 - 1.4 7.6 10.0 1.6 7.5 10.0 1.1 1 0 0 1 1 1 0 Otopetrin DUF3408 PF11888.8 CDI86331.1 - 1.4 9.0 21.0 1.9 8.6 21.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) LptF_LptG PF03739.14 CDI86331.1 - 1.6 7.5 7.9 3.6 6.3 7.9 1.6 1 1 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG PepSY_TM_like_2 PF16357.5 CDI86331.1 - 1.7 8.6 8.4 2.1 8.3 8.4 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like STAC2_u1 PF16664.5 CDI86331.1 - 1.8 9.1 17.3 2.1 8.8 17.3 1.0 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 NPR3 PF03666.13 CDI86331.1 - 1.9 7.2 18.9 2.2 7.0 18.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.12 CDI86331.1 - 2.1 8.1 24.0 2.6 7.8 24.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_S49_N PF08496.10 CDI86331.1 - 3 7.9 18.0 5.1 7.2 18.0 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PepSY_TM PF03929.16 CDI86331.1 - 3.1 7.4 9.0 4 7.0 9.0 1.3 1 0 0 1 1 1 0 PepSY-associated TM region DUF4628 PF15429.6 CDI86331.1 - 3.2 7.4 18.7 3.9 7.1 18.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) Endonuc_Holl PF10107.9 CDI86331.1 - 3.4 7.5 13.0 3.9 7.3 13.0 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Gti1_Pac2 PF09729.9 CDI86331.1 - 3.5 7.7 17.6 4 7.5 17.6 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family FliP PF00813.20 CDI86331.1 - 3.6 7.4 9.5 4.5 7.1 9.5 1.1 1 0 0 1 1 1 0 FliP family Membralin PF09746.9 CDI86331.1 - 3.6 6.5 11.9 3.8 6.5 11.9 1.1 1 0 0 1 1 1 0 Tumour-associated protein RP-C_C PF11800.8 CDI86331.1 - 3.7 7.6 17.5 4.3 7.4 17.5 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region ORC_WH_C PF18137.1 CDI86331.1 - 3.8 7.6 19.6 5.7 7.0 19.6 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal EMC3_TMCO1 PF01956.16 CDI86331.1 - 4 7.2 16.4 4.8 6.9 16.4 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like GNAT_acetyltr_2 PF13718.6 CDI86331.1 - 4.4 6.6 13.0 5.3 6.4 13.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DUF4834 PF16118.5 CDI86331.1 - 4.5 8.3 27.7 14 6.7 27.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2227 PF09988.9 CDI86331.1 - 4.6 7.1 7.4 33 4.3 7.4 1.9 1 1 0 1 1 1 0 Uncharacterized metal-binding protein (DUF2227) DUF868 PF05910.12 CDI86331.1 - 4.9 6.7 11.1 5.5 6.5 11.1 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF868) AIF_C PF14721.6 CDI86331.1 - 4.9 7.5 17.2 6.5 7.1 17.2 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Folliculin PF11704.8 CDI86331.1 - 5 7.0 14.4 5.7 6.8 14.4 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Endostatin PF06482.11 CDI86331.1 - 5.4 6.4 19.1 6 6.2 19.1 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Anoctamin PF04547.12 CDI86331.1 - 5.7 5.7 8.6 6.6 5.5 8.6 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel MMU163 PF17119.5 CDI86331.1 - 6 5.9 11.1 6.7 5.8 11.1 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis ALMT PF11744.8 CDI86331.1 - 6.1 5.6 15.9 6.8 5.4 15.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM60A PF15396.6 CDI86331.1 - 6.3 6.7 16.4 7.1 6.6 16.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Velvet PF11754.8 CDI86331.1 - 6.4 6.6 20.6 7.1 6.5 20.6 1.0 1 0 0 1 1 1 0 Velvet factor PPL5 PF18168.1 CDI86331.1 - 7.2 5.8 16.2 8.2 5.6 16.2 1.0 1 0 0 1 1 1 0 Prim-pol family 5 DUF4746 PF15928.5 CDI86331.1 - 7.4 5.9 17.4 8.8 5.7 17.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) XRN_M PF17846.1 CDI86331.1 - 8 5.3 13.8 8.7 5.2 13.8 1.1 1 0 0 1 1 1 0 Xrn1 helical domain DUF3381 PF11861.8 CDI86331.1 - 8 6.2 24.9 10 5.9 24.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) GOLD_2 PF13897.6 CDI86331.1 - 8.6 6.9 6.5 11 6.5 6.5 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF3292 PF11696.8 CDI86331.1 - 9.5 4.4 16.0 11 4.2 16.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) HGTP_anticodon2 PF12745.7 CDI86331.1 - 9.6 5.6 19.0 11 5.4 19.0 1.0 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs FYDLN_acid PF09538.10 CDI86331.1 - 9.8 6.9 15.1 14 6.5 15.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) TCP PF03634.13 CDI86332.1 - 1.5 9.4 37.8 2.1 8.9 37.8 1.1 1 0 0 1 1 1 0 TCP family transcription factor RR_TM4-6 PF06459.12 CDI86332.1 - 3.3 7.5 36.3 4.2 7.1 36.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CCSAP PF15748.5 CDI86332.1 - 4.4 7.4 42.6 5.4 7.1 42.6 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Endostatin PF06482.11 CDI86332.1 - 5.7 6.3 28.4 6.2 6.2 28.4 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SelP_N PF04592.14 CDI86332.1 - 8.4 5.7 26.1 10 5.4 26.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Activator_LAG-3 PF11498.8 CDI86332.1 - 8.8 5.2 64.6 10 4.9 64.6 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 K_channel_TID PF07941.11 CDI86333.1 - 0.0077 16.7 12.8 0.0077 16.7 12.8 5.2 3 2 0 3 3 1 1 Potassium channel Kv1.4 tandem inactivation domain eIF-3_zeta PF05091.12 CDI86333.1 - 0.095 11.7 12.0 0.089 11.8 12.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SID-1_RNA_chan PF13965.6 CDI86333.1 - 0.27 9.6 2.1 0.24 9.8 2.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Presenilin PF01080.17 CDI86333.1 - 0.64 8.7 20.6 0.72 8.5 20.6 1.2 1 0 0 1 1 1 0 Presenilin PA26 PF04636.13 CDI86333.1 - 1.2 8.0 10.8 1.2 8.0 10.8 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF572 PF04502.13 CDI86333.1 - 1.2 8.7 19.6 1.4 8.4 19.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Suf PF05843.14 CDI86333.1 - 1.3 9.0 21.1 2 8.3 21.1 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hamartin PF04388.12 CDI86333.1 - 2.2 6.8 19.1 2.8 6.5 19.1 1.2 1 0 0 1 1 1 0 Hamartin protein IATP PF04568.12 CDI86333.1 - 2.3 8.7 23.0 0.03 14.7 13.3 2.1 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP Folate_carrier PF01770.18 CDI86333.1 - 3.1 6.4 5.1 4 6.1 5.1 1.4 1 0 0 1 1 1 0 Reduced folate carrier Serinc PF03348.15 CDI86333.1 - 5.5 5.8 10.7 6.5 5.6 10.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) TFIIA PF03153.13 CDI86333.1 - 7.3 6.5 50.2 9.2 6.1 50.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit VIR_N PF15912.5 CDI86334.1 - 5 6.6 17.7 5.5 6.5 17.7 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal DUF3402 PF11882.8 CDI86335.1 - 0.0019 17.4 10.8 0.0019 17.4 10.8 4.3 4 0 0 4 4 4 4 Domain of unknown function (DUF3402) DUF1645 PF07816.11 CDI86335.1 - 0.006 17.2 5.4 0.006 17.2 5.4 6.5 4 2 2 6 6 6 1 Protein of unknown function (DUF1645) SUZ PF12752.7 CDI86336.1 - 0.018 15.8 0.6 0.058 14.2 0.6 1.9 1 0 0 1 1 1 0 SUZ domain IMUP PF15761.5 CDI86336.1 - 0.031 15.0 8.8 0.061 14.0 6.5 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein SR-25 PF10500.9 CDI86336.1 - 0.13 11.9 10.3 0.24 11.0 10.3 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CsiV PF10972.8 CDI86337.1 - 0.0093 15.7 2.6 0.0093 15.7 2.6 2.1 2 0 0 2 2 2 1 Peptidoglycan-binding protein, CsiV Presenilin PF01080.17 CDI86337.1 - 0.13 11.0 16.7 0.17 10.6 16.7 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI86337.1 - 0.38 9.7 12.5 0.48 9.4 12.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DnaJ-X PF14308.6 CDI86337.1 - 2.9 7.3 10.6 0.12 11.8 1.8 2.0 2 0 0 2 2 2 0 X-domain of DnaJ-containing DUF4834 PF16118.5 CDI86337.1 - 3.4 8.7 20.4 8 7.5 7.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ureide_permease PF07168.11 CDI86337.1 - 5.1 5.7 4.5 2.7 6.7 0.1 1.9 2 0 0 2 2 2 0 Ureide permease Apc15p PF05841.11 CDI86337.1 - 8.2 7.3 24.8 0.53 11.1 7.0 2.1 2 0 0 2 2 2 0 Apc15p protein CPSF100_C PF13299.6 CDI86337.1 - 8.5 6.5 15.0 5.1 7.2 2.5 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Eapp_C PF10238.9 CDI86337.1 - 9.3 6.3 15.8 3.1 7.9 1.8 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF4834 PF16118.5 CDI86338.1 - 0.001 20.0 27.8 0.042 14.8 11.1 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) DUF3807 PF12720.7 CDI86338.1 - 0.0017 18.7 26.6 0.02 15.1 10.5 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3807) EPL1 PF10513.9 CDI86338.1 - 0.0027 18.1 20.4 0.0089 16.4 5.0 2.2 2 0 0 2 2 2 1 Enhancer of polycomb-like eIF-3_zeta PF05091.12 CDI86338.1 - 0.0045 16.0 31.0 0.044 12.8 13.0 2.0 2 0 0 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CCSAP PF15748.5 CDI86338.1 - 0.0078 16.4 24.2 0.016 15.4 8.7 2.2 2 0 0 2 2 2 1 Centriole, cilia and spindle-associated TRM13 PF05206.14 CDI86338.1 - 0.008 15.7 2.5 0.008 15.7 2.5 2.2 2 0 0 2 2 2 1 Methyltransferase TRM13 EIIBC-GUT_N PF03612.14 CDI86338.1 - 0.0088 15.8 20.5 0.27 10.9 9.6 2.2 2 0 0 2 2 2 2 Sorbitol phosphotransferase enzyme II N-terminus TCP PF03634.13 CDI86338.1 - 0.011 16.3 23.1 0.16 12.5 11.3 2.2 2 0 0 2 2 2 0 TCP family transcription factor RPN2_C PF18004.1 CDI86338.1 - 0.012 15.5 2.0 0.012 15.5 2.0 2.3 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain RR_TM4-6 PF06459.12 CDI86338.1 - 0.025 14.4 19.9 0.072 12.9 6.7 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF4484 PF14831.6 CDI86338.1 - 0.038 14.0 11.9 0.1 12.7 2.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) Tim54 PF11711.8 CDI86338.1 - 0.04 12.7 15.9 0.12 11.1 5.3 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 TFB6 PF17110.5 CDI86338.1 - 0.044 13.5 13.1 0.42 10.3 0.4 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH EOS1 PF12326.8 CDI86338.1 - 0.064 13.2 11.7 0.4 10.6 3.1 2.2 2 0 0 2 2 2 0 N-glycosylation protein DUF719 PF05334.13 CDI86338.1 - 0.065 13.4 21.3 0.85 9.8 9.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF719) EFTUD2 PF16004.5 CDI86338.1 - 0.066 13.8 22.2 0.051 14.2 6.3 2.2 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus DUF4207 PF13904.6 CDI86338.1 - 0.068 12.9 41.2 0.7 9.5 17.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) DUF3408 PF11888.8 CDI86338.1 - 0.069 13.3 24.6 0.7 10.0 4.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) RIFIN PF02009.16 CDI86338.1 - 0.071 13.0 19.0 0.25 11.2 11.8 2.1 2 0 0 2 2 2 0 Rifin FAM60A PF15396.6 CDI86338.1 - 0.077 13.0 17.0 0.11 12.5 5.6 2.2 2 0 0 2 2 2 0 Protein Family FAM60A DUF4820 PF16091.5 CDI86338.1 - 0.09 12.1 18.0 0.085 12.2 4.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) CobT PF06213.12 CDI86338.1 - 0.097 12.1 35.1 0.28 10.5 15.6 2.4 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF5327 PF17261.2 CDI86338.1 - 0.1 13.4 33.7 0.95 10.2 15.4 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5327) CNDH2_C PF16858.5 CDI86338.1 - 0.11 12.3 22.5 0.27 11.1 7.7 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Fer4_22 PF17179.4 CDI86338.1 - 0.13 13.1 19.2 0.86 10.5 3.1 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain DUF3405 PF11885.8 CDI86338.1 - 0.14 10.7 18.6 0.21 10.1 5.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3405) Myc_N PF01056.18 CDI86338.1 - 0.19 11.6 15.8 0.23 11.3 9.4 2.0 2 0 0 2 2 2 0 Myc amino-terminal region RPA43_OB PF17875.1 CDI86338.1 - 0.19 12.3 17.4 0.9 10.2 5.4 2.2 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I BORG_CEP PF14957.6 CDI86338.1 - 0.21 12.7 15.9 2.2 9.4 5.0 2.2 2 0 0 2 2 2 0 Cdc42 effector LTV PF04180.14 CDI86338.1 - 0.22 11.2 17.4 0.69 9.6 1.1 2.1 2 0 0 2 2 2 0 Low temperature viability protein MMR1 PF08505.10 CDI86338.1 - 0.24 11.7 32.4 0.36 11.1 12.0 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein FAM176 PF14851.6 CDI86338.1 - 0.24 11.1 17.3 0.98 9.1 6.0 2.2 2 0 0 2 2 2 0 FAM176 family Coilin_N PF15862.5 CDI86338.1 - 0.28 11.0 28.0 0.073 12.9 8.3 2.4 2 0 0 2 2 2 0 Coilin N-terminus G0-G1_switch_2 PF15103.6 CDI86338.1 - 0.37 11.2 22.7 0.84 10.1 8.2 2.4 2 0 0 2 2 2 0 G0/G1 switch protein 2 DUF3801 PF12687.7 CDI86338.1 - 0.38 10.8 22.7 0.54 10.3 8.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) LIM_bind PF01803.16 CDI86338.1 - 0.48 9.9 20.6 0.28 10.7 6.5 2.2 2 0 0 2 2 2 0 LIM-domain binding protein CFIA_Pcf11 PF11526.8 CDI86338.1 - 0.51 10.9 24.4 0.46 11.0 8.3 2.4 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 Spt20 PF12090.8 CDI86338.1 - 0.54 9.8 83.8 0.15 11.6 28.0 2.2 2 0 0 2 2 2 0 Spt20 family MH2 PF03166.14 CDI86338.1 - 0.59 10.3 16.8 2.4 8.4 4.2 2.2 2 0 0 2 2 2 0 MH2 domain DUF4471 PF14740.6 CDI86338.1 - 0.62 9.2 14.9 0.4 9.8 3.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) RIC3 PF15361.6 CDI86338.1 - 0.64 10.4 15.9 2 8.8 5.2 2.3 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 YABBY PF04690.13 CDI86338.1 - 0.65 10.5 18.6 2.8 8.5 7.3 2.3 2 0 0 2 2 2 0 YABBY protein Dpy19 PF10034.9 CDI86338.1 - 0.67 8.1 12.4 0.027 12.7 1.5 2.0 2 0 0 2 2 2 0 Q-cell neuroblast polarisation Dala_Dala_lig_N PF01820.21 CDI86338.1 - 0.75 10.3 3.9 9.6 6.7 0.5 2.3 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus Tsg PF04668.12 CDI86338.1 - 0.78 10.4 16.8 0.66 10.7 3.4 2.2 2 0 0 2 2 2 0 Twisted gastrulation (Tsg) protein conserved region TERB2 PF15101.6 CDI86338.1 - 0.9 9.5 39.9 0.52 10.3 16.9 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 PNISR PF15996.5 CDI86338.1 - 0.92 9.7 28.0 1.3 9.2 11.0 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Spt5_N PF11942.8 CDI86338.1 - 0.94 10.5 19.0 1.8 9.6 6.7 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal U1snRNP70_N PF12220.8 CDI86338.1 - 0.99 10.1 22.6 2.9 8.6 5.1 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal AIF_C PF14721.6 CDI86338.1 - 1 9.8 21.8 0.56 10.6 7.4 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4746 PF15928.5 CDI86338.1 - 1.2 8.5 17.6 0.53 9.7 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF2722 PF10846.8 CDI86338.1 - 1.2 8.0 67.3 0.97 8.3 33.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Peptidase_S49_N PF08496.10 CDI86338.1 - 1.3 9.1 23.3 2.5 8.1 8.3 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal RskA PF10099.9 CDI86338.1 - 1.3 9.3 61.3 3.3 8.0 45.1 2.9 1 1 0 2 2 2 0 Anti-sigma-K factor rskA DUF3984 PF13136.6 CDI86338.1 - 1.5 8.2 19.2 0.4 10.1 6.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3984) BAF1_ABF1 PF04684.13 CDI86338.1 - 1.5 7.8 23.0 0.5 9.4 11.1 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor PRP1_N PF06424.12 CDI86338.1 - 1.6 9.2 22.3 1.7 9.1 8.0 2.2 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Eapp_C PF10238.9 CDI86338.1 - 1.6 8.8 30.3 0.12 12.4 7.8 2.4 3 0 0 3 3 2 0 E2F-associated phosphoprotein DUF1980 PF09323.10 CDI86338.1 - 1.6 8.6 19.1 0.6 10.0 6.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) ALMT PF11744.8 CDI86338.1 - 1.6 7.4 17.2 0.82 8.4 5.6 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter DUF1764 PF08576.10 CDI86338.1 - 1.6 9.6 24.6 1.8 9.5 9.8 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) DUF2464 PF10240.9 CDI86338.1 - 1.7 8.1 15.5 2.1 7.8 5.8 2.1 2 0 0 2 2 2 0 Multivesicular body subunit 12 DUF2370 PF10176.9 CDI86338.1 - 1.9 8.1 9.8 0.66 9.6 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) API5 PF05918.11 CDI86338.1 - 2 7.2 24.1 1.1 8.0 10.5 2.1 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) DUF3295 PF11702.8 CDI86338.1 - 2.1 7.6 24.7 3.1 7.1 4.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) ORC5_C PF14630.6 CDI86338.1 - 2.5 7.6 14.8 4.1 6.8 3.9 2.2 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus ATAD4 PF15321.6 CDI86338.1 - 2.5 9.5 19.3 6.4 8.2 7.2 2.3 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Ureide_permease PF07168.11 CDI86338.1 - 3.4 6.3 13.8 0.63 8.7 2.3 2.2 2 0 0 2 2 2 0 Ureide permease Pex26 PF07163.12 CDI86338.1 - 3.5 6.8 28.3 0.29 10.4 10.3 2.3 2 0 0 2 2 2 0 Pex26 protein FAM150 PF15129.6 CDI86338.1 - 4.3 7.5 28.1 5.7 7.1 13.1 2.3 2 0 0 2 2 2 0 FAM150 family PH_4 PF15404.6 CDI86338.1 - 5.2 6.8 23.3 1 9.1 9.1 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain AUX_IAA PF02309.16 CDI86338.1 - 5.6 6.8 19.9 61 3.3 20.0 2.2 1 1 0 1 1 1 0 AUX/IAA family PBP1_TM PF14812.6 CDI86338.1 - 6 7.3 11.6 2.5 8.5 1.8 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NEMP PF10225.9 CDI86338.1 - 6 6.4 15.3 2.4 7.8 4.3 2.2 2 0 0 2 2 2 0 NEMP family Pal1 PF08316.11 CDI86338.1 - 6 7.6 15.2 7.6 7.3 5.7 2.2 2 0 0 2 2 2 0 Pal1 cell morphology protein Slu7 PF11708.8 CDI86338.1 - 6.7 6.4 26.5 1.5 8.5 9.1 2.1 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor Afi1 PF07792.12 CDI86338.1 - 7.3 7.1 24.5 5.1 7.6 4.8 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MFAP1 PF06991.11 CDI86338.1 - 7.5 6.3 31.7 4.8 7.0 15.7 2.2 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing SART-1 PF03343.13 CDI86338.1 - 8.1 4.9 28.2 2.5 6.5 11.4 2.0 2 0 0 2 2 2 0 SART-1 family DUF4569 PF15133.6 CDI86338.1 - 8.2 6.1 28.2 4.4 6.9 12.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4569) MAM33 PF02330.16 CDI86338.1 - 8.5 6.3 26.8 5.9 6.8 11.4 2.1 2 0 0 2 2 2 0 Mitochondrial glycoprotein MAP17 PF15807.5 CDI86338.1 - 8.7 6.6 18.2 6.4 7.0 6.6 2.2 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 TFIIA PF03153.13 CDI86339.1 - 0.046 13.7 20.9 0.07 13.1 20.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PhoQ_Sensor PF08918.10 CDI86339.1 - 0.052 13.4 1.4 0.052 13.4 1.4 1.5 2 0 0 2 2 2 0 PhoQ Sensor Vps8 PF12816.7 CDI86339.1 - 0.072 12.6 2.3 0.088 12.3 2.3 1.1 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 SART-1 PF03343.13 CDI86339.1 - 0.085 11.4 9.6 0.1 11.1 9.6 1.0 1 0 0 1 1 1 0 SART-1 family Menin PF05053.13 CDI86339.1 - 0.13 10.6 6.6 0.15 10.4 6.6 1.0 1 0 0 1 1 1 0 Menin DUF4820 PF16091.5 CDI86339.1 - 0.18 11.1 7.6 0.21 10.9 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Med15 PF09606.10 CDI86339.1 - 0.43 9.2 24.6 0.55 8.9 24.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3138 PF11336.8 CDI86339.1 - 0.55 8.8 14.4 0.68 8.5 14.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Presenilin PF01080.17 CDI86339.1 - 1 8.1 10.2 1 8.0 10.2 1.0 1 0 0 1 1 1 0 Presenilin 2OG-FeII_Oxy_5 PF13759.6 CDI86339.1 - 1.4 9.4 4.2 1.5 9.3 3.2 1.5 1 1 1 2 2 2 0 Putative 2OG-Fe(II) oxygenase Big_2 PF02368.18 CDI86339.1 - 2.9 7.8 12.1 4.3 7.3 11.6 1.6 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 2) BAT2_N PF07001.11 CDI86339.1 - 2.9 8.3 16.4 3.8 7.9 16.4 1.1 1 0 0 1 1 1 0 BAT2 N-terminus Mif2_N PF15624.6 CDI86339.1 - 3 8.6 9.7 4 8.2 9.7 1.1 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal DUF2076 PF09849.9 CDI86339.1 - 4.7 7.2 23.5 5.6 6.9 23.5 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Ndc1_Nup PF09531.10 CDI86339.1 - 5.4 5.6 11.7 6.1 5.4 11.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Conotoxin PF02950.17 CDI86339.1 - 7.6 7.6 7.8 20 6.3 0.4 2.2 2 0 0 2 2 2 0 Conotoxin NiFe-hyd_HybE PF11939.8 CDI86339.1 - 8.3 6.3 11.0 3.9 7.4 8.6 1.6 1 1 1 2 2 2 0 [NiFe]-hydrogenase assembly, chaperone, HybE SID-1_RNA_chan PF13965.6 CDI86340.1 - 0.0013 17.2 11.9 0.0014 17.1 11.9 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Zip PF02535.22 CDI86340.1 - 0.0053 16.0 10.6 0.006 15.8 10.6 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter O-antigen_lig PF13425.6 CDI86340.1 - 0.0081 15.0 12.5 0.0087 14.9 12.5 1.0 1 0 0 1 1 1 1 O-antigen ligase like membrane protein Presenilin PF01080.17 CDI86340.1 - 0.013 14.3 26.9 0.015 14.1 26.9 1.0 1 0 0 1 1 1 0 Presenilin Afi1 PF07792.12 CDI86340.1 - 0.02 15.4 19.4 0.026 15.0 19.4 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking TRAP_alpha PF03896.16 CDI86340.1 - 0.027 13.7 11.5 0.032 13.5 11.5 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PA26 PF04636.13 CDI86340.1 - 0.089 11.7 18.2 0.099 11.5 18.2 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Ureide_permease PF07168.11 CDI86340.1 - 0.09 11.5 9.0 0.11 11.3 9.0 1.1 1 0 0 1 1 1 0 Ureide permease NPR3 PF03666.13 CDI86340.1 - 0.091 11.5 22.2 0.11 11.3 22.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Otopetrin PF03189.13 CDI86340.1 - 0.16 10.8 10.9 0.2 10.4 10.9 1.2 1 0 0 1 1 1 0 Otopetrin SARAF PF06682.12 CDI86340.1 - 0.17 11.5 17.1 0.25 11.0 17.1 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis CLN3 PF02487.17 CDI86340.1 - 0.17 10.9 15.7 0.22 10.5 15.7 1.2 1 0 0 1 1 1 0 CLN3 protein FHIPEP PF00771.20 CDI86340.1 - 0.2 10.1 16.6 0.3 9.5 16.6 1.3 1 0 0 1 1 1 0 FHIPEP family MFS_4 PF06779.14 CDI86340.1 - 0.28 10.5 0.1 0.4 9.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB DREPP PF05558.12 CDI86340.1 - 0.89 9.4 8.6 1.1 9.2 8.6 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide DUF4131 PF13567.6 CDI86340.1 - 1.1 8.9 9.7 1.4 8.5 9.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) AMP-binding PF00501.28 CDI86340.1 - 1.1 7.8 7.8 1.2 7.6 7.8 1.1 1 0 0 1 1 1 0 AMP-binding enzyme CNDH2_C PF16858.5 CDI86340.1 - 1.2 8.9 28.7 1.5 8.7 28.7 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Paramyxo_ncap PF00973.19 CDI86340.1 - 1.3 7.9 20.8 1.5 7.7 20.8 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein CD20 PF04103.15 CDI86340.1 - 1.3 9.1 4.3 3.9 7.5 4.3 1.8 1 1 0 1 1 1 0 CD20-like family K_trans PF02705.16 CDI86340.1 - 1.6 7.2 6.8 2.1 6.7 6.8 1.2 1 0 0 1 1 1 0 K+ potassium transporter CDC45 PF02724.14 CDI86340.1 - 1.8 6.8 26.9 2.1 6.5 26.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Lin-8 PF03353.15 CDI86340.1 - 1.9 8.0 31.7 2.2 7.8 31.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Tmp39 PF10271.9 CDI86340.1 - 2.4 7.0 5.5 2.6 6.9 5.5 1.2 1 0 0 1 1 1 0 Putative transmembrane protein TerC PF03741.16 CDI86340.1 - 2.8 7.6 3.2 5 6.8 3.2 1.7 1 1 0 1 1 1 0 Integral membrane protein TerC family Rtf2 PF04641.12 CDI86340.1 - 3.6 6.9 25.3 4.2 6.7 25.3 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger ASC PF00858.24 CDI86340.1 - 4.5 6.1 14.3 4.8 6.0 14.3 1.2 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel RR_TM4-6 PF06459.12 CDI86340.1 - 4.9 6.9 33.1 5.9 6.6 33.1 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2828 PF11443.8 CDI86340.1 - 5 5.1 22.5 6.7 4.7 22.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Gti1_Pac2 PF09729.9 CDI86340.1 - 5.3 7.1 21.9 7.3 6.6 21.9 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF740 PF05340.12 CDI86340.1 - 7.2 5.2 13.6 8.9 4.9 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) FCP1_C PF09309.10 CDI86341.1 - 0.00079 19.4 8.0 0.00099 19.1 8.0 1.0 1 0 0 1 1 1 1 FCP1, C-terminal Spt20 PF12090.8 CDI86341.1 - 0.0011 18.6 24.0 0.0014 18.3 24.0 1.1 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI86341.1 - 0.002 17.2 18.8 0.0025 16.8 18.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI86341.1 - 0.011 15.7 20.3 0.013 15.5 20.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4643 PF15485.6 CDI86341.1 - 0.11 12.3 6.0 0.12 12.1 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4643) Peptidase_M56 PF05569.11 CDI86341.1 - 0.11 11.6 1.5 0.12 11.5 1.5 1.0 1 0 0 1 1 1 0 BlaR1 peptidase M56 CSG2 PF16965.5 CDI86341.1 - 0.18 10.7 7.5 0.22 10.4 7.5 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Orf78 PF06024.12 CDI86341.1 - 0.23 11.8 7.9 0.1 12.9 2.2 2.0 2 0 0 2 2 2 0 Orf78 (ac78) DUF4407 PF14362.6 CDI86341.1 - 0.25 10.7 3.9 0.23 10.8 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Presenilin PF01080.17 CDI86341.1 - 0.26 10.0 10.7 0.31 9.7 10.7 1.1 1 0 0 1 1 1 0 Presenilin Lin-8 PF03353.15 CDI86341.1 - 0.27 10.8 10.3 0.35 10.4 10.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Macoilin PF09726.9 CDI86341.1 - 0.29 9.7 15.4 0.37 9.3 15.4 1.1 1 0 0 1 1 1 0 Macoilin family MFS_Mycoplasma PF07672.13 CDI86341.1 - 0.35 10.1 2.1 0.39 10.0 2.1 1.0 1 0 0 1 1 1 0 Mycoplasma MFS transporter SPT16 PF08644.11 CDI86341.1 - 0.38 10.9 5.5 0.57 10.4 5.5 1.2 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) Rot1 PF10681.9 CDI86341.1 - 0.42 10.1 7.1 0.062 12.8 3.1 1.6 1 1 1 2 2 2 0 Chaperone for protein-folding within the ER, fungal CLN3 PF02487.17 CDI86341.1 - 0.57 9.2 5.0 0.71 8.9 5.0 1.2 1 0 0 1 1 1 0 CLN3 protein ArsP_2 PF11449.8 CDI86341.1 - 0.81 8.8 1.8 0.8 8.8 1.8 1.1 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter DUF1635 PF07795.11 CDI86341.1 - 1.5 8.6 15.2 2.5 7.9 15.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DUF4199 PF13858.6 CDI86341.1 - 3.2 8.1 5.0 4.5 7.7 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DivIC PF04977.15 CDI86341.1 - 8.5 6.2 17.7 13 5.6 17.7 1.3 1 0 0 1 1 1 0 Septum formation initiator MAP65_ASE1 PF03999.12 CDI86342.1 - 0.2 10.3 5.9 0.33 9.6 5.9 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Ndc1_Nup PF09531.10 CDI86342.1 - 0.38 9.4 8.6 0.81 8.3 8.6 1.5 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RskA PF10099.9 CDI86342.1 - 0.38 11.0 54.2 0.02 15.2 6.6 5.1 3 1 1 5 5 5 0 Anti-sigma-K factor rskA SPX PF03105.19 CDI86342.1 - 0.52 10.2 13.7 1.1 9.1 13.7 1.5 1 0 0 1 1 1 0 SPX domain TFIIA PF03153.13 CDI86342.1 - 1.2 9.1 35.9 0.018 15.0 23.1 2.8 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI86342.1 - 3.2 7.3 29.9 0.58 9.7 19.5 2.3 2 0 0 2 2 2 0 Spt20 family DUF1645 PF07816.11 CDI86342.1 - 3.3 8.2 20.9 0.026 15.1 11.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) Macoilin PF09726.9 CDI86342.1 - 3.6 6.0 14.6 6.6 5.2 14.6 1.3 1 0 0 1 1 1 0 Macoilin family DUF1840 PF08895.11 CDI86343.1 - 0.008 16.5 6.2 0.008 16.5 6.2 6.0 3 1 2 5 5 5 2 Domain of unknown function (DUF1840) FA_hydroxylase PF04116.13 CDI86343.1 - 0.39 11.0 12.8 4.7 7.6 0.6 2.4 2 0 0 2 2 2 0 Fatty acid hydroxylase superfamily DUF4366 PF14283.6 CDI86343.1 - 3.8 7.6 33.0 0.046 13.8 3.6 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4366) SR-25 PF10500.9 CDI86344.1 - 0.0024 17.5 28.2 0.0028 17.3 28.2 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF1635 PF07795.11 CDI86344.1 - 1.2 9.0 24.1 1.3 8.8 24.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) CCDC106 PF15794.5 CDI86344.1 - 1.2 8.8 25.6 1.4 8.6 25.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CDK2AP PF09806.9 CDI86344.1 - 2.8 7.9 25.5 3 7.9 25.5 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein RAP1 PF07218.11 CDI86344.1 - 7.1 4.8 11.4 6.8 4.8 11.4 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4636 PF15468.6 CDI86344.1 - 7.7 6.1 21.1 8.4 6.0 21.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) DUF4718 PF15842.5 CDI86344.1 - 9.9 5.9 18.5 16 5.3 18.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4718) Pkinase PF00069.25 CDI86345.1 - 0.017 14.5 0.0 0.032 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain RIFIN PF02009.16 CDI86346.1 - 2.6 7.8 6.5 2.8 7.7 6.5 1.0 1 0 0 1 1 1 0 Rifin Corona_nucleoca PF00937.18 CDI86346.1 - 6.5 5.7 10.0 6.9 5.6 10.0 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Peptidase_C97 PF05903.14 CDI86347.1 - 9.2e-18 64.5 0.0 1.9e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 PPPDE putative peptidase domain TFIIA PF03153.13 CDI86347.1 - 0.0023 18.0 33.3 0.0023 18.0 33.3 4.2 3 1 1 4 4 4 1 Transcription factor IIA, alpha/beta subunit RAP1 PF07218.11 CDI86347.1 - 3.4 5.8 10.5 5.8 5.1 10.5 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) TPR_1 PF00515.28 CDI86348.1 - 1.7e-05 24.4 7.5 0.00012 21.7 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDI86348.1 - 3.8e-05 23.5 8.6 9.3e-05 22.3 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat SUIM_assoc PF16619.5 CDI86348.1 - 4.8e-05 23.4 0.0 4.8e-05 23.4 0.0 8.9 2 2 1 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 TPR_12 PF13424.6 CDI86348.1 - 0.0023 18.2 1.7 0.0023 18.2 1.7 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDI86348.1 - 0.0093 16.1 0.1 0.0093 16.1 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDI86348.1 - 0.01 15.7 4.2 0.024 14.5 0.8 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDI86348.1 - 0.012 16.3 1.6 0.012 16.3 1.6 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF4667 PF15700.5 CDI86348.1 - 0.025 14.7 0.1 0.025 14.7 0.1 5.1 3 1 0 4 4 4 0 Domain of unknown function (DUF4667) TPR_7 PF13176.6 CDI86348.1 - 0.034 14.2 0.5 0.76 10.0 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDI86348.1 - 0.051 14.4 0.7 0.051 14.4 0.7 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Es2 PF09751.9 CDI86349.1 - 3.1 7.5 37.5 4 7.1 37.5 1.1 1 0 0 1 1 1 0 Nuclear protein Es2 TFIIA PF03153.13 CDI86350.1 - 7.5e-06 26.2 30.8 9.6e-06 25.8 30.8 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI86350.1 - 0.00069 18.0 22.0 0.00069 18.0 22.0 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Pex14_N PF04695.13 CDI86350.1 - 0.0013 19.4 21.3 0.0013 19.4 21.3 1.7 2 0 0 2 2 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Endostatin PF06482.11 CDI86350.1 - 0.0034 16.9 10.8 0.0039 16.7 10.8 1.1 1 0 0 1 1 1 1 Collagenase NC10 and Endostatin DDHD PF02862.17 CDI86350.1 - 0.0043 17.2 9.4 0.0048 17.1 9.4 1.2 1 0 0 1 1 1 1 DDHD domain Exonuc_VII_L PF02601.15 CDI86350.1 - 0.0048 16.5 10.8 0.005 16.5 10.8 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit SLC12 PF03522.15 CDI86350.1 - 0.0049 16.0 11.1 0.0053 15.8 11.1 1.1 1 0 0 1 1 1 1 Solute carrier family 12 DUF3295 PF11702.8 CDI86350.1 - 0.007 15.8 13.7 0.0082 15.6 13.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3295) AF-4 PF05110.13 CDI86350.1 - 0.0076 14.4 18.6 0.0084 14.3 18.6 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein DUF913 PF06025.12 CDI86350.1 - 0.011 14.8 5.3 0.012 14.7 5.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CPSF100_C PF13299.6 CDI86350.1 - 0.015 15.5 8.8 0.021 15.0 8.8 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SpoIIP PF07454.11 CDI86350.1 - 0.018 14.5 12.9 0.022 14.2 12.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SID-1_RNA_chan PF13965.6 CDI86350.1 - 0.021 13.3 1.8 0.022 13.2 1.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Neur_chan_memb PF02932.16 CDI86350.1 - 0.025 14.7 9.8 0.032 14.3 9.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 CDI86350.1 - 0.03 14.2 16.1 0.038 13.8 16.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF5427 PF10310.9 CDI86350.1 - 0.046 12.7 20.0 0.059 12.3 20.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Tim54 PF11711.8 CDI86350.1 - 0.062 12.1 11.8 0.078 11.7 11.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 BORG_CEP PF14957.6 CDI86350.1 - 0.069 14.3 11.1 0.096 13.9 11.1 1.2 1 0 0 1 1 1 0 Cdc42 effector PA26 PF04636.13 CDI86350.1 - 0.078 11.9 7.5 0.081 11.8 7.5 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) FAM60A PF15396.6 CDI86350.1 - 0.087 12.8 9.7 0.11 12.5 9.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SARAF PF06682.12 CDI86350.1 - 0.092 12.4 15.7 0.13 11.9 15.7 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis AUX_IAA PF02309.16 CDI86350.1 - 0.12 12.2 6.7 0.14 12.0 6.7 1.2 1 0 0 1 1 1 0 AUX/IAA family Presenilin PF01080.17 CDI86350.1 - 0.13 11.0 22.7 0.16 10.7 22.7 1.1 1 0 0 1 1 1 0 Presenilin PTPRCAP PF15713.5 CDI86350.1 - 0.17 12.2 19.1 0.25 11.6 19.1 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated VIR_N PF15912.5 CDI86350.1 - 0.18 11.4 6.9 0.21 11.1 6.9 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Lin-8 PF03353.15 CDI86350.1 - 0.2 11.2 18.9 0.23 11.0 18.9 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2828 PF11443.8 CDI86350.1 - 0.23 9.5 15.7 0.27 9.3 15.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) GREB1 PF15782.5 CDI86350.1 - 0.24 8.5 14.8 0.25 8.4 14.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PIP5K PF01504.18 CDI86350.1 - 0.25 10.6 11.6 0.3 10.3 11.6 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase STAC2_u1 PF16664.5 CDI86350.1 - 0.27 11.7 18.1 0.48 10.9 18.1 1.3 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Cellulose_synt PF03552.14 CDI86350.1 - 0.29 9.6 2.9 0.31 9.5 2.9 1.0 1 0 0 1 1 1 0 Cellulose synthase Serinc PF03348.15 CDI86350.1 - 0.3 10.0 6.6 0.33 9.8 6.6 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF3292 PF11696.8 CDI86350.1 - 0.37 9.1 11.2 0.45 8.8 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) YABBY PF04690.13 CDI86350.1 - 0.45 11.1 11.6 0.62 10.6 11.6 1.2 1 0 0 1 1 1 0 YABBY protein EOS1 PF12326.8 CDI86350.1 - 0.47 10.4 7.3 0.74 9.7 7.3 1.4 1 0 0 1 1 1 0 N-glycosylation protein Gti1_Pac2 PF09729.9 CDI86350.1 - 0.48 10.5 15.9 0.66 10.1 15.9 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family NPR3 PF03666.13 CDI86350.1 - 0.57 8.9 19.0 0.73 8.6 19.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ribosomal_60s PF00428.19 CDI86350.1 - 0.75 10.4 19.9 4.5 7.9 1.3 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein FliP PF00813.20 CDI86350.1 - 0.86 9.5 5.0 1.5 8.6 5.0 1.5 1 0 0 1 1 1 0 FliP family Pal1 PF08316.11 CDI86350.1 - 0.88 10.3 6.5 1.3 9.8 6.5 1.3 1 0 0 1 1 1 0 Pal1 cell morphology protein Hid1 PF12722.7 CDI86350.1 - 0.95 7.5 16.3 1.1 7.2 16.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Band_3_cyto PF07565.13 CDI86350.1 - 1.1 9.0 16.4 1.7 8.4 16.4 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Macoilin PF09726.9 CDI86350.1 - 1.3 7.4 15.1 1.8 7.0 15.1 1.2 1 0 0 1 1 1 0 Macoilin family DUF2464 PF10240.9 CDI86350.1 - 1.3 8.5 9.3 1.6 8.2 9.3 1.2 1 0 0 1 1 1 0 Multivesicular body subunit 12 Peptidase_S64 PF08192.11 CDI86350.1 - 1.5 7.2 15.4 1.8 6.9 15.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 Sin_N PF04801.13 CDI86350.1 - 1.6 7.9 26.2 2 7.5 26.2 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Ctr PF04145.15 CDI86350.1 - 1.8 9.2 9.1 2.9 8.5 9.1 1.5 1 0 0 1 1 1 0 Ctr copper transporter family Spem1 PF15670.5 CDI86350.1 - 1.9 8.0 18.3 2.8 7.4 18.3 1.2 1 0 0 1 1 1 0 Spermatid maturation protein 1 ALMT PF11744.8 CDI86350.1 - 2.1 7.1 14.6 2.5 6.8 14.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Plasmodium_Vir PF05795.11 CDI86350.1 - 2.2 7.6 7.8 2.5 7.5 7.8 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Paramyxo_ncap PF00973.19 CDI86350.1 - 2.3 7.1 14.0 2.8 6.8 14.0 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein MCM_bind PF09739.9 CDI86350.1 - 2.3 6.6 18.7 3 6.2 18.7 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Ndc1_Nup PF09531.10 CDI86350.1 - 2.4 6.7 15.8 2.8 6.5 15.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup eIF-3_zeta PF05091.12 CDI86350.1 - 2.5 7.0 28.6 3.1 6.7 28.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MDM10 PF12519.8 CDI86350.1 - 2.6 6.8 15.9 3.8 6.3 15.9 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 O-antigen_lig PF13425.6 CDI86350.1 - 2.9 6.6 7.9 3.6 6.3 7.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein HAUS6_N PF14661.6 CDI86350.1 - 3.3 7.2 20.2 4.8 6.7 20.2 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF4647 PF15504.6 CDI86350.1 - 3.7 6.5 21.4 4.4 6.3 21.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) LMBR1 PF04791.16 CDI86350.1 - 3.8 6.3 6.9 4.1 6.2 6.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2126 PF09899.9 CDI86350.1 - 3.8 5.5 13.3 4.7 5.2 13.3 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Otopetrin PF03189.13 CDI86350.1 - 5.1 5.8 9.5 7.5 5.3 9.5 1.3 1 0 0 1 1 1 0 Otopetrin DUF2370 PF10176.9 CDI86350.1 - 5.7 6.5 8.7 7.9 6.0 8.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) NEMP PF10225.9 CDI86350.1 - 5.8 6.5 5.3 9.7 5.8 5.3 1.4 1 0 0 1 1 1 0 NEMP family MDM31_MDM32 PF08118.11 CDI86350.1 - 6.2 5.4 12.8 9.3 4.8 12.8 1.2 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins CBP_BcsG PF11658.8 CDI86350.1 - 6.5 5.0 13.0 9.1 4.5 13.0 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DUF4638 PF15472.6 CDI86350.1 - 6.8 6.3 18.1 9.1 5.9 18.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF1764 PF08576.10 CDI86350.1 - 7.2 7.6 17.0 15 6.6 17.0 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) OATP PF03137.20 CDI86350.1 - 8.3 4.6 9.3 12 4.1 9.3 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family HGTP_anticodon2 PF12745.7 CDI86350.1 - 8.5 5.8 18.0 11 5.4 18.0 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs DUF4175 PF13779.6 CDI86350.1 - 8.7 4.1 45.1 13 3.5 45.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PPL5 PF18168.1 CDI86350.1 - 9.1 5.5 16.5 12 5.1 16.5 1.1 1 0 0 1 1 1 0 Prim-pol family 5 LAP1C PF05609.12 CDI86351.1 - 0.0049 16.0 15.4 0.0049 16.0 15.4 3.0 1 1 1 3 3 3 1 Lamina-associated polypeptide 1C (LAP1C) DUF2207 PF09972.9 CDI86351.1 - 0.0063 15.3 0.2 0.0063 15.3 0.2 2.5 2 2 0 2 2 2 1 Predicted membrane protein (DUF2207) Pkinase PF00069.25 CDI86352.1 - 3.2e-19 69.3 4.0 2.2e-14 53.4 0.1 4.5 4 0 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI86352.1 - 3.5e-07 29.8 0.7 0.0021 17.4 0.0 3.4 2 1 0 2 2 2 2 Protein tyrosine kinase AF-4 PF05110.13 CDI86352.1 - 0.00038 18.7 37.0 0.00038 18.7 37.0 3.2 3 0 0 3 3 3 1 AF-4 proto-oncoprotein Oxidored_q3 PF00499.20 CDI86352.1 - 0.16 11.7 7.6 0.97 9.2 0.3 4.4 3 1 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 RskA PF10099.9 CDI86352.1 - 0.18 12.1 0.0 0.18 12.1 0.0 12.8 4 4 5 10 10 10 0 Anti-sigma-K factor rskA KdpC PF02669.15 CDI86353.1 - 0.016 15.0 0.5 0.024 14.5 0.5 1.2 1 0 0 1 1 1 0 K+-transporting ATPase, c chain Tic110 PF16940.5 CDI86353.1 - 1.8 6.9 4.1 2.4 6.5 4.1 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter RskA PF10099.9 CDI86354.1 - 0.039 14.3 49.0 0.91 9.8 13.8 3.1 3 0 0 3 3 3 0 Anti-sigma-K factor rskA SARAF PF06682.12 CDI86356.1 - 0.0021 17.8 2.2 0.0028 17.4 2.2 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Neur_chan_memb PF02932.16 CDI86356.1 - 0.0031 17.6 1.2 0.0037 17.4 1.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF4207 PF13904.6 CDI86356.1 - 0.0064 16.2 16.2 0.0086 15.8 16.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) TFIIA PF03153.13 CDI86356.1 - 0.0084 16.2 21.6 0.0092 16.0 21.6 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Cadherin_C_2 PF16492.5 CDI86356.1 - 0.082 13.7 0.4 0.27 12.0 0.4 1.8 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal DUF4667 PF15700.5 CDI86356.1 - 0.11 12.6 5.0 0.14 12.3 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) DUF4834 PF16118.5 CDI86356.1 - 0.13 13.2 16.3 0.23 12.5 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) FAM60A PF15396.6 CDI86356.1 - 0.16 12.0 4.6 0.22 11.5 4.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Coilin_N PF15862.5 CDI86356.1 - 0.18 11.6 7.8 2.6 7.8 6.3 2.1 2 0 0 2 2 2 0 Coilin N-terminus Tmemb_9 PF05434.11 CDI86356.1 - 1.8 8.5 8.9 4.7 7.1 0.0 2.2 2 0 0 2 2 2 0 TMEM9 NEMP PF10225.9 CDI86356.1 - 2 8.0 9.2 3.4 7.3 0.7 2.0 1 1 1 2 2 2 0 NEMP family CobS PF02654.15 CDI86356.1 - 3.9 7.6 13.5 4.5 7.4 13.5 1.1 1 0 0 1 1 1 0 Cobalamin-5-phosphate synthase R_equi_Vir PF05526.11 CDI86356.1 - 4.2 7.2 23.0 1.9 8.3 7.4 2.1 1 1 1 2 2 2 0 Rhodococcus equi virulence-associated protein Hid1 PF12722.7 CDI86356.1 - 6.6 4.7 7.8 7.3 4.6 7.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SID-1_RNA_chan PF13965.6 CDI86356.1 - 7.1 4.9 11.0 16 3.8 11.0 1.5 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 DUF5308 PF17233.2 CDI86356.1 - 9.7 6.4 20.4 1.6 8.9 7.1 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5308) Stevor PF17410.2 CDI86356.1 - 9.7 5.6 13.2 19 4.7 13.2 1.4 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF677 PF05055.12 CDI86357.1 - 0.0032 16.4 1.3 0.0037 16.2 1.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF677) BAF1_ABF1 PF04684.13 CDI86357.1 - 0.61 9.1 17.8 0.74 8.8 17.8 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor WDCP PF15390.6 CDI86357.1 - 0.69 8.2 16.9 0.84 7.9 16.9 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family FAM60A PF15396.6 CDI86357.1 - 4.2 7.3 11.9 6.4 6.7 11.9 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Herpes_DNAp_acc PF04929.12 CDI86357.1 - 4.3 6.2 15.7 5.1 6.0 15.7 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor ISG65-75 PF11727.8 CDI86357.1 - 4.6 6.4 16.9 5.6 6.1 16.9 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein AUX_IAA PF02309.16 CDI86357.1 - 8.7 6.1 13.3 12 5.7 13.3 1.2 1 0 0 1 1 1 0 AUX/IAA family Ndc1_Nup PF09531.10 CDI86357.1 - 9.3 4.8 24.4 11 4.5 24.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup zinc_ribbon_16 PF17034.5 CDI86358.1 - 0.99 9.6 4.1 1.2 9.4 3.6 1.4 1 1 0 1 1 1 0 Zinc-ribbon like family Lin-8 PF03353.15 CDI86358.1 - 2.9 7.4 21.0 3.7 7.0 21.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TFIIA PF03153.13 CDI86358.1 - 3.6 7.5 38.5 5.2 7.0 38.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI86359.1 - 5.9e-05 23.4 0.3 5.9e-05 23.4 0.3 15.8 7 6 2 9 9 9 2 Anti-sigma-K factor rskA MAM33 PF02330.16 CDI86359.1 - 0.0013 18.7 0.2 0.0013 18.7 0.2 8.5 8 1 1 9 9 9 1 Mitochondrial glycoprotein SR-25 PF10500.9 CDI86360.1 - 9.6e-05 22.1 22.2 0.00012 21.7 22.2 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI86360.1 - 0.097 12.3 55.2 0.17 11.5 22.0 2.1 2 0 0 2 2 2 0 Spt20 family PNISR PF15996.5 CDI86360.1 - 0.12 12.7 26.2 0.15 12.3 26.2 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR FAM60A PF15396.6 CDI86360.1 - 0.5 10.3 17.6 0.63 10.0 17.6 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Med24_N PF11277.8 CDI86360.1 - 0.5 8.3 15.6 0.66 7.9 15.6 1.3 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal MAT1 PF06391.13 CDI86360.1 - 0.56 10.0 26.6 0.7 9.7 26.6 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF3807 PF12720.7 CDI86360.1 - 0.66 10.2 27.1 0.95 9.7 27.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) RIFIN PF02009.16 CDI86360.1 - 1.2 9.0 23.9 1.6 8.6 23.9 1.0 1 0 0 1 1 1 0 Rifin Presenilin PF01080.17 CDI86360.1 - 1.5 7.5 26.1 2.2 6.9 26.1 1.4 1 0 0 1 1 1 0 Presenilin DUF45 PF01863.17 CDI86360.1 - 1.8 8.6 13.7 2.2 8.3 13.7 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF45 Miga PF10265.9 CDI86360.1 - 2.1 7.2 22.5 2.5 7.0 22.5 1.0 1 0 0 1 1 1 0 Mitoguardin Mem_trans PF03547.18 CDI86360.1 - 2.2 6.6 9.8 2.8 6.3 9.8 1.3 1 0 0 1 1 1 0 Membrane transport protein Apt1 PF10351.9 CDI86360.1 - 2.4 6.9 19.8 2.7 6.8 19.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SAGA-Tad1 PF12767.7 CDI86360.1 - 2.4 7.8 21.0 3 7.5 21.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Draxin PF15550.6 CDI86360.1 - 2.6 7.8 17.4 3.4 7.4 17.4 1.1 1 0 0 1 1 1 0 Draxin Activator_LAG-3 PF11498.8 CDI86360.1 - 2.7 6.9 56.5 0.53 9.2 16.2 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Peptidase_S64 PF08192.11 CDI86360.1 - 3.1 6.2 28.0 3.6 6.0 28.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 Smg8_Smg9 PF10220.9 CDI86360.1 - 4.3 5.5 24.8 5 5.3 24.8 1.0 1 0 0 1 1 1 0 Smg8_Smg9 CCDC84 PF14968.6 CDI86360.1 - 5.2 6.6 22.2 6.2 6.4 22.2 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 SLC12 PF03522.15 CDI86360.1 - 5.8 5.8 23.1 6.8 5.6 23.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI86360.1 - 6.4 4.9 41.0 7.4 4.7 41.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ALMT PF11744.8 CDI86360.1 - 7.1 5.3 21.1 8.4 5.1 21.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Pol_alpha_B_N PF08418.10 CDI86360.1 - 7.4 6.5 22.9 10 6.0 22.9 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Utp14 PF04615.13 CDI86360.1 - 7.7 5.0 26.9 9.2 4.7 26.9 1.0 1 0 0 1 1 1 0 Utp14 protein YfhO PF09586.10 CDI86360.1 - 8.4 4.5 14.5 10 4.2 14.5 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF4647 PF15504.6 CDI86360.1 - 8.6 5.3 25.1 11 5.0 25.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) MPC PF03650.13 CDI86360.1 - 9.4 6.4 12.6 0.19 11.9 4.2 2.2 2 0 0 2 2 2 0 Mitochondrial pyruvate carriers DUF572 PF04502.13 CDI86360.1 - 9.5 5.7 24.9 15 5.1 24.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) SDA1 PF05285.12 CDI86361.1 - 0.2 11.0 32.1 0.26 10.7 32.1 1.2 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 CDI86361.1 - 0.33 10.5 31.0 0.36 10.4 31.0 1.1 1 0 0 1 1 1 0 PPP4R2 FAM199X PF15814.5 CDI86361.1 - 1.2 8.1 23.8 1.4 7.9 23.8 1.1 1 0 0 1 1 1 0 Protein family FAM199X RIFIN PF02009.16 CDI86361.1 - 6.7 6.5 15.0 8.3 6.2 15.0 1.0 1 0 0 1 1 1 0 Rifin CDC27 PF09507.10 CDI86361.1 - 8.9 5.6 36.8 11 5.3 36.8 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Etmic-2 PF06670.11 CDI86362.1 - 2.8e-56 191.1 12.3 1e-35 123.4 3.4 2.0 1 1 1 2 2 2 2 Microneme protein Etmic-2 DUF5308 PF17233.2 CDI86365.1 - 0.055 13.7 9.8 0.063 13.5 9.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5308) EIIBC-GUT_N PF03612.14 CDI86365.1 - 0.14 11.9 8.2 0.13 12.0 8.2 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF5523 PF17661.1 CDI86365.1 - 0.17 11.6 11.6 0.19 11.4 11.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) SelP_N PF04592.14 CDI86365.1 - 0.25 10.7 14.4 0.26 10.7 14.4 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region AIF_C PF14721.6 CDI86365.1 - 0.27 11.6 7.0 0.28 11.5 7.0 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term G0-G1_switch_2 PF15103.6 CDI86365.1 - 0.33 11.4 6.4 0.4 11.1 6.4 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 SMN PF06003.12 CDI86365.1 - 0.34 10.1 4.8 0.42 9.8 4.8 1.0 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Connexin PF00029.19 CDI86365.1 - 0.38 10.5 9.7 0.41 10.4 9.7 1.0 1 0 0 1 1 1 0 Connexin Pex14_N PF04695.13 CDI86365.1 - 0.39 11.4 15.2 0.41 11.3 15.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NicO PF03824.16 CDI86365.1 - 0.41 9.9 3.8 0.46 9.8 3.8 1.0 1 0 0 1 1 1 0 High-affinity nickel-transport protein DUF2098 PF09871.9 CDI86365.1 - 0.48 10.8 5.6 0.54 10.6 5.6 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) CPSF100_C PF13299.6 CDI86365.1 - 0.49 10.6 9.2 0.54 10.4 9.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Coilin_N PF15862.5 CDI86365.1 - 0.51 10.1 11.5 0.56 10.0 11.5 1.2 1 0 0 1 1 1 0 Coilin N-terminus HA2 PF04408.23 CDI86365.1 - 0.56 10.5 4.5 0.67 10.3 4.5 1.2 1 0 0 1 1 1 0 Helicase associated domain (HA2) Presenilin PF01080.17 CDI86365.1 - 0.65 8.7 13.8 0.72 8.5 13.8 1.0 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI86365.1 - 0.66 9.7 10.7 0.69 9.7 10.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Folate_carrier PF01770.18 CDI86365.1 - 0.77 8.4 6.4 0.79 8.4 6.4 1.0 1 0 0 1 1 1 0 Reduced folate carrier UPF0560 PF10577.9 CDI86365.1 - 1 7.8 19.0 1 7.8 19.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Paf1 PF03985.13 CDI86365.1 - 1.1 8.2 15.2 1.2 8.1 15.2 1.0 1 0 0 1 1 1 0 Paf1 ORC_WH_C PF18137.1 CDI86365.1 - 1.2 9.2 10.6 1.3 9.1 10.6 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal DUF1764 PF08576.10 CDI86365.1 - 1.3 9.9 10.2 1.7 9.6 10.2 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) OATP PF03137.20 CDI86365.1 - 1.4 7.1 6.0 1.6 6.9 6.0 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family V_ATPase_I PF01496.19 CDI86365.1 - 1.5 6.6 11.7 1.5 6.6 11.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Serinc PF03348.15 CDI86365.1 - 2 7.3 7.6 2 7.3 7.6 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) CSG2 PF16965.5 CDI86365.1 - 2.1 7.2 5.5 2.1 7.2 5.5 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator eIF-3_zeta PF05091.12 CDI86365.1 - 2.6 6.9 13.6 2.6 6.9 13.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI86365.1 - 3.2 7.6 26.4 3.4 7.6 26.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CDI86365.1 - 3.7 7.9 14.2 4.6 7.6 14.2 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Neur_chan_memb PF02932.16 CDI86365.1 - 4.2 7.3 9.2 4.5 7.3 9.2 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.17 CDI86365.1 - 4.3 7.4 11.9 4.7 7.3 11.9 1.0 1 0 0 1 1 1 0 DDHD domain DUF2347 PF09804.9 CDI86365.1 - 4.8 6.7 9.3 5.2 6.6 9.3 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) CLN3 PF02487.17 CDI86365.1 - 5.2 6.0 8.7 5.3 6.0 8.7 1.0 1 0 0 1 1 1 0 CLN3 protein CobT PF06213.12 CDI86365.1 - 6 6.2 19.6 7.1 5.9 19.6 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT EOS1 PF12326.8 CDI86365.1 - 7 6.6 7.0 7.4 6.5 7.0 1.1 1 0 0 1 1 1 0 N-glycosylation protein Orf78 PF06024.12 CDI86365.1 - 7.6 6.9 6.3 9.8 6.5 6.3 1.4 1 0 0 1 1 1 0 Orf78 (ac78) DUF3682 PF12446.8 CDI86365.1 - 7.9 7.0 27.2 10 6.6 27.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Zip PF02535.22 CDI86365.1 - 8.5 5.5 10.8 8 5.6 10.8 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Ureide_permease PF07168.11 CDI86365.1 - 8.8 5.0 5.9 9.8 4.8 5.9 1.0 1 0 0 1 1 1 0 Ureide permease Sec62 PF03839.16 CDI86365.1 - 8.8 5.8 8.4 9.3 5.7 8.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Band_3_cyto PF07565.13 CDI86365.1 - 10 5.9 14.0 11 5.7 14.0 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Wtap PF17098.5 CDI86366.1 - 2.3e-41 141.3 0.0 3.5e-40 137.5 0.0 2.0 2 0 0 2 2 2 1 WTAP/Mum2p family ATG16 PF08614.11 CDI86366.1 - 0.0012 19.1 12.9 0.0012 19.1 12.9 2.3 2 1 0 2 2 1 1 Autophagy protein 16 (ATG16) Phage_GP20 PF06810.11 CDI86366.1 - 0.054 13.3 8.7 0.95 9.3 0.7 2.8 1 1 1 3 3 3 0 Phage minor structural protein GP20 WD40_alt PF14077.6 CDI86366.1 - 0.12 12.3 1.4 7.1 6.6 0.1 2.5 2 0 0 2 2 2 0 Alternative WD40 repeat motif KASH_CCD PF14662.6 CDI86366.1 - 0.25 11.2 11.2 1.1 9.1 11.2 2.0 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH GAS PF13851.6 CDI86366.1 - 0.25 10.7 9.0 0.74 9.1 9.0 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding GIT_CC PF16559.5 CDI86366.1 - 0.26 11.2 3.7 1.6 8.7 0.7 2.5 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor YabA PF06156.13 CDI86366.1 - 0.34 11.6 7.3 0.2 12.3 2.2 2.9 1 1 0 2 2 2 0 Initiation control protein YabA ZapB PF06005.12 CDI86366.1 - 0.46 11.0 17.5 0.23 11.9 1.5 4.2 1 1 3 4 4 4 0 Cell division protein ZapB NYD-SP28_assoc PF14775.6 CDI86366.1 - 0.54 10.4 6.6 3.5 7.8 0.1 3.3 3 0 0 3 3 3 0 Sperm tail C-terminal domain UPF0242 PF06785.11 CDI86366.1 - 0.62 10.2 5.8 1.4 9.0 5.5 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 CDI86366.1 - 0.62 8.9 11.2 0.81 8.5 5.9 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Cnn_1N PF07989.11 CDI86366.1 - 0.63 10.2 8.2 64 3.8 8.3 3.2 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 NPV_P10 PF05531.12 CDI86366.1 - 1.4 9.4 3.7 3.8 8.1 1.0 2.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DivIC PF04977.15 CDI86366.1 - 2.8 7.8 10.1 2.1 8.2 1.8 3.1 2 1 1 3 3 3 0 Septum formation initiator Csm1_N PF18504.1 CDI86366.1 - 3.4 8.1 9.3 35 4.8 0.1 3.7 2 1 1 3 3 3 0 Csm1 N-terminal domain HALZ PF02183.18 CDI86366.1 - 5.5 7.3 14.7 2 8.7 1.2 3.8 2 1 2 4 4 4 0 Homeobox associated leucine zipper NUC173 PF08161.12 CDI86367.1 - 6.9e-17 61.8 6.3 7.5e-16 58.4 0.2 4.0 3 0 0 3 3 3 1 NUC173 domain SARAF PF06682.12 CDI86367.1 - 4.9e-05 23.1 15.3 4.9e-05 23.1 15.3 4.2 4 1 0 4 4 4 2 SOCE-associated regulatory factor of calcium homoeostasis DUF755 PF05501.11 CDI86367.1 - 0.0051 17.1 5.8 0.0051 17.1 5.8 9.3 8 2 1 9 9 9 1 Domain of unknown function (DUF755) SR-25 PF10500.9 CDI86367.1 - 0.0076 15.9 11.0 0.0076 15.9 11.0 5.4 5 1 0 5 5 5 1 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI86367.1 - 0.027 14.5 0.6 0.027 14.5 0.6 10.9 9 2 0 9 9 9 0 Unstructured region C-term to UIM in Ataxin3 SR-25 PF10500.9 CDI86368.1 - 0.00028 20.6 29.7 0.00034 20.3 29.7 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein NPR3 PF03666.13 CDI86368.1 - 0.77 8.5 32.9 0.86 8.3 32.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Menin PF05053.13 CDI86368.1 - 1.3 7.3 27.4 1.5 7.1 27.4 1.0 1 0 0 1 1 1 0 Menin CDC45 PF02724.14 CDI86368.1 - 1.3 7.2 31.5 1.5 7.1 31.5 1.0 1 0 0 1 1 1 0 CDC45-like protein SMYLE_N PF18615.1 CDI86368.1 - 1.3 8.5 24.5 1.6 8.2 24.5 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Presenilin PF01080.17 CDI86368.1 - 1.7 7.3 41.7 2 7.1 41.7 1.0 1 0 0 1 1 1 0 Presenilin MAJIN PF15077.6 CDI86368.1 - 2.2 8.0 24.0 2.5 7.8 24.0 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein SOBP PF15279.6 CDI86368.1 - 2.3 8.8 29.6 2.5 8.6 29.6 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein FAM60A PF15396.6 CDI86368.1 - 2.4 8.1 27.3 3.7 7.5 27.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A BAF1_ABF1 PF04684.13 CDI86368.1 - 2.9 6.9 33.0 3.4 6.6 33.0 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Hid1 PF12722.7 CDI86368.1 - 3.5 5.6 36.0 3.8 5.5 36.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1387 PF07139.11 CDI86368.1 - 3.8 7.1 32.3 5.6 6.6 32.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF5427 PF10310.9 CDI86368.1 - 4.5 6.1 34.6 6 5.7 34.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) XRN_M PF17846.1 CDI86368.1 - 5.1 5.9 25.9 5.8 5.8 25.9 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Raftlin PF15250.6 CDI86368.1 - 5.2 5.7 29.7 6.1 5.5 29.7 1.0 1 0 0 1 1 1 0 Raftlin RR_TM4-6 PF06459.12 CDI86368.1 - 5.3 6.8 33.3 6.6 6.5 33.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MRP-S26 PF14943.6 CDI86368.1 - 5.4 6.9 26.7 7.1 6.5 26.7 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Dicty_REP PF05086.12 CDI86368.1 - 5.7 4.8 29.6 6 4.7 29.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Hamartin PF04388.12 CDI86368.1 - 5.7 5.5 31.6 6.5 5.3 31.6 1.0 1 0 0 1 1 1 0 Hamartin protein Nop53 PF07767.11 CDI86368.1 - 5.7 6.2 33.9 6.9 6.0 33.9 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Neur_chan_memb PF02932.16 CDI86368.1 - 5.8 6.9 26.2 9.2 6.2 26.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CAC1F_C PF16885.5 CDI86368.1 - 6.6 6.3 24.2 7.7 6.1 24.2 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term SLC12 PF03522.15 CDI86368.1 - 6.6 5.6 34.8 8 5.4 34.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Suf PF05843.14 CDI86368.1 - 6.7 6.6 41.2 8 6.4 41.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Zip PF02535.22 CDI86368.1 - 6.8 5.8 26.3 7.9 5.6 26.3 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter PNISR PF15996.5 CDI86368.1 - 9.1 6.5 42.7 11 6.3 42.7 1.0 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR POX PF07526.11 CDI86369.1 - 0.0017 18.9 5.2 0.039 14.5 0.8 2.4 2 1 0 2 2 2 2 Associated with HOX RNA_pol_3_Rpc31 PF11705.8 CDI86369.1 - 0.16 12.2 5.7 0.26 11.5 5.7 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Macoilin PF09726.9 CDI86369.1 - 0.27 9.8 1.2 0.35 9.4 1.2 1.3 1 0 0 1 1 1 0 Macoilin family Cwf_Cwc_15 PF04889.12 CDI86369.1 - 0.47 10.2 16.8 0.29 10.8 7.0 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 CDI86369.1 - 1.1 9.6 9.2 2.1 8.8 9.2 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Ipi1_N PF12333.8 CDI86369.1 - 1.3 9.6 4.5 1.4e+02 3.1 6.1 2.6 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation DDRGK PF09756.9 CDI86370.1 - 2.2 7.8 43.4 0.26 10.8 24.3 2.3 2 0 0 2 2 2 0 DDRGK domain SR-25 PF10500.9 CDI86370.1 - 5.3 6.6 60.0 0.2 11.2 16.0 3.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Nop25 PF09805.9 CDI86370.1 - 5.8 7.4 40.7 0.24 11.9 25.6 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Pex14_N PF04695.13 CDI86371.1 - 0.00041 21.1 17.1 0.00063 20.4 17.1 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1676 PF07898.13 CDI86371.1 - 0.009 16.1 0.3 0.012 15.7 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1676) Asp_Arg_Hydrox PF05118.15 CDI86371.1 - 0.014 15.2 0.5 0.014 15.2 0.5 1.9 2 0 0 2 2 2 0 Aspartyl/Asparaginyl beta-hydroxylase ALMT PF11744.8 CDI86371.1 - 0.018 13.9 9.9 0.02 13.8 9.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Hid1 PF12722.7 CDI86371.1 - 0.023 12.9 8.4 0.023 12.9 8.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LMBR1 PF04791.16 CDI86371.1 - 0.027 13.4 9.0 0.033 13.1 9.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein CSG2 PF16965.5 CDI86371.1 - 0.085 11.8 5.2 0.13 11.2 5.2 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator Sec62 PF03839.16 CDI86371.1 - 0.11 12.0 10.5 0.12 11.9 10.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Tweety PF04906.13 CDI86371.1 - 0.13 10.9 10.4 0.15 10.7 10.4 1.0 1 0 0 1 1 1 0 Tweety LAP1C PF05609.12 CDI86371.1 - 0.24 10.5 19.0 0.26 10.3 19.0 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Neur_chan_memb PF02932.16 CDI86371.1 - 0.26 11.3 6.6 0.32 11.0 6.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2370 PF10176.9 CDI86371.1 - 0.26 10.9 5.8 0.38 10.4 5.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) CLN3 PF02487.17 CDI86371.1 - 0.31 10.0 9.1 0.38 9.8 9.1 1.1 1 0 0 1 1 1 0 CLN3 protein Plasmodium_Vir PF05795.11 CDI86371.1 - 0.32 10.4 2.5 0.38 10.1 2.5 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RR_TM4-6 PF06459.12 CDI86371.1 - 0.34 10.7 14.4 0.41 10.4 14.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GET2 PF08690.10 CDI86371.1 - 0.43 10.2 18.4 0.48 10.0 18.4 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 GTP_EFTU_D2 PF03144.25 CDI86371.1 - 0.49 10.8 2.8 0.78 10.2 2.8 1.7 1 1 0 1 1 1 0 Elongation factor Tu domain 2 Ndc1_Nup PF09531.10 CDI86371.1 - 0.51 9.0 7.7 0.64 8.6 7.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CemA PF03040.14 CDI86371.1 - 0.55 10.1 10.8 0.64 9.9 10.8 1.1 1 0 0 1 1 1 0 CemA family SLC12 PF03522.15 CDI86371.1 - 0.64 9.0 14.8 0.73 8.8 14.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Membralin PF09746.9 CDI86371.1 - 0.8 8.7 8.7 0.85 8.6 8.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein HCO3_cotransp PF00955.21 CDI86371.1 - 0.84 8.4 6.5 0.92 8.3 6.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family Hydin_ADK PF17213.3 CDI86371.1 - 1 9.6 11.3 1.2 9.4 11.3 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Band_3_cyto PF07565.13 CDI86371.1 - 1.3 8.8 11.2 1.8 8.3 11.2 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FAM60A PF15396.6 CDI86371.1 - 1.5 8.8 9.9 1.8 8.5 9.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF2828 PF11443.8 CDI86371.1 - 2.1 6.3 13.0 2.5 6.1 13.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PRP1_N PF06424.12 CDI86371.1 - 2.2 8.7 16.3 2.7 8.4 16.3 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal CAF1 PF04857.20 CDI86371.1 - 2.4 7.3 9.1 2.7 7.1 9.1 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease SID-1_RNA_chan PF13965.6 CDI86371.1 - 3.2 6.1 7.7 3.7 5.9 7.7 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Glyco_transf_41 PF13844.6 CDI86371.1 - 4.8 5.5 10.6 5.5 5.3 10.6 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 Asp-B-Hydro_N PF05279.11 CDI86371.1 - 9.7 6.2 16.8 12 5.8 16.8 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF1764 PF08576.10 CDI86372.1 - 2.9 8.8 15.9 3.8 8.5 15.9 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) zinc_ribbon_12 PF11331.8 CDI86375.1 - 0.58 10.0 0.1 0.58 10.0 0.1 3.4 2 1 0 2 2 2 0 Probable zinc-ribbon domain Peroxin-13_N PF04088.13 CDI86375.1 - 1.3 9.3 0.0 1.3 9.3 0.0 3.1 2 1 1 3 3 3 0 Peroxin 13, N-terminal region TPR_2 PF07719.17 CDI86376.1 - 2.9e-05 23.9 0.5 0.033 14.3 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI86376.1 - 0.00099 19.3 4.2 0.051 13.8 0.3 1.9 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CDI86376.1 - 0.0011 19.4 1.0 0.0019 18.7 0.6 1.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI86376.1 - 0.0019 18.9 1.7 0.14 13.0 0.3 2.7 1 1 2 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 CDI86376.1 - 0.0054 17.2 1.1 0.0065 16.9 1.1 1.1 1 0 0 1 1 1 1 Bacterial transcriptional activator domain TPR_1 PF00515.28 CDI86376.1 - 0.012 15.4 0.1 0.21 11.5 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2232 PF09991.9 CDI86379.1 - 0.00021 20.6 3.2 0.00028 20.2 3.2 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2232) TFIIA PF03153.13 CDI86379.1 - 0.00045 20.3 29.4 0.00046 20.3 29.4 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit FAM176 PF14851.6 CDI86379.1 - 0.0013 18.4 1.2 0.0017 18.1 1.2 1.3 1 0 0 1 1 1 1 FAM176 family G6B PF15096.6 CDI86379.1 - 0.0027 17.6 0.6 0.003 17.4 0.6 1.1 1 0 0 1 1 1 1 G6B family Orf78 PF06024.12 CDI86379.1 - 0.0037 17.5 1.0 0.0067 16.7 1.0 1.5 1 0 0 1 1 1 1 Orf78 (ac78) FAM60A PF15396.6 CDI86379.1 - 0.0041 17.2 1.1 0.0042 17.1 1.1 1.1 1 0 0 1 1 1 1 Protein Family FAM60A RR_TM4-6 PF06459.12 CDI86379.1 - 0.0048 16.8 2.9 0.0048 16.8 2.9 1.2 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI86379.1 - 0.0052 15.6 6.0 0.0056 15.5 6.0 1.2 1 0 0 1 1 1 1 Presenilin Suf PF05843.14 CDI86379.1 - 0.0068 16.4 6.3 0.0068 16.4 6.3 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) DDHD PF02862.17 CDI86379.1 - 0.007 16.6 3.9 0.0072 16.5 3.9 1.1 1 0 0 1 1 1 1 DDHD domain Eapp_C PF10238.9 CDI86379.1 - 0.0083 16.2 7.0 0.012 15.7 7.0 1.3 1 0 0 1 1 1 1 E2F-associated phosphoprotein DUF913 PF06025.12 CDI86379.1 - 0.0087 15.1 1.9 0.0088 15.1 1.9 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) SpoIIP PF07454.11 CDI86379.1 - 0.012 15.1 4.9 0.014 14.8 4.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TERB2 PF15101.6 CDI86379.1 - 0.018 15.1 9.5 0.021 14.9 9.5 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF2722 PF10846.8 CDI86379.1 - 0.022 13.8 19.1 0.029 13.3 19.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Glt_symporter PF03616.14 CDI86379.1 - 0.024 13.3 0.7 0.033 12.9 0.7 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter Tim54 PF11711.8 CDI86379.1 - 0.026 13.3 3.7 0.033 13.0 3.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 OATP PF03137.20 CDI86379.1 - 0.028 12.7 1.4 0.036 12.4 1.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SelP_N PF04592.14 CDI86379.1 - 0.029 13.8 9.7 0.035 13.5 9.7 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region U1snRNP70_N PF12220.8 CDI86379.1 - 0.03 15.0 7.1 0.045 14.4 7.1 1.3 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal SID-1_RNA_chan PF13965.6 CDI86379.1 - 0.03 12.7 0.8 0.033 12.6 0.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI86379.1 - 0.032 13.2 3.9 0.032 13.1 3.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Velvet PF11754.8 CDI86379.1 - 0.034 14.1 7.2 0.039 13.9 7.2 1.1 1 0 0 1 1 1 0 Velvet factor Neur_chan_memb PF02932.16 CDI86379.1 - 0.035 14.2 1.6 0.035 14.2 1.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FHIPEP PF00771.20 CDI86379.1 - 0.046 12.2 10.7 0.053 12.0 10.7 1.0 1 0 0 1 1 1 0 FHIPEP family MDFI PF15316.6 CDI86379.1 - 0.048 13.8 5.4 0.063 13.4 5.4 1.2 1 0 0 1 1 1 0 MyoD family inhibitor CPSF73-100_C PF11718.8 CDI86379.1 - 0.058 12.9 7.0 0.097 12.2 7.0 1.3 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term eIF-3_zeta PF05091.12 CDI86379.1 - 0.059 12.3 8.8 0.063 12.3 8.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ctr PF04145.15 CDI86379.1 - 0.07 13.8 1.7 0.093 13.4 1.7 1.2 1 0 0 1 1 1 0 Ctr copper transporter family EPL1 PF10513.9 CDI86379.1 - 0.072 13.5 6.9 0.1 13.0 6.9 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF1980 PF09323.10 CDI86379.1 - 0.089 12.7 1.6 0.1 12.5 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Consortin_C PF15281.6 CDI86379.1 - 0.089 12.8 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Consortin C-terminus TOM13 PF08219.11 CDI86379.1 - 0.11 12.4 0.9 0.19 11.7 0.9 1.4 1 0 0 1 1 1 0 Outer membrane protein TOM13 ORC5_C PF14630.6 CDI86379.1 - 0.12 11.9 5.2 0.12 11.8 5.2 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus CSG2 PF16965.5 CDI86379.1 - 0.15 11.0 3.0 0.16 10.9 3.0 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator PAT1 PF09770.9 CDI86379.1 - 0.15 10.3 17.9 0.17 10.2 17.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 HCO3_cotransp PF00955.21 CDI86379.1 - 0.16 10.8 1.2 0.17 10.7 1.2 1.0 1 0 0 1 1 1 0 HCO3- transporter family AIF_C PF14721.6 CDI86379.1 - 0.17 12.2 7.6 0.032 14.6 4.5 1.5 2 0 0 2 2 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Baculo_PP31 PF05311.11 CDI86379.1 - 0.19 11.2 4.6 0.21 11.0 4.6 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) THOC2_N PF16134.5 CDI86379.1 - 0.19 10.3 6.8 0.2 10.2 6.8 1.2 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus NEMP PF10225.9 CDI86379.1 - 0.21 11.2 2.1 0.26 10.9 2.1 1.2 1 0 0 1 1 1 0 NEMP family EOS1 PF12326.8 CDI86379.1 - 0.22 11.5 1.0 0.24 11.3 1.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein PIP5K PF01504.18 CDI86379.1 - 0.24 10.6 5.1 0.3 10.3 5.1 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF4834 PF16118.5 CDI86379.1 - 0.28 12.2 9.3 0.45 11.5 9.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4457 PF14652.6 CDI86379.1 - 0.28 10.4 2.6 0.33 10.2 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) Spore_coat_CotO PF14153.6 CDI86379.1 - 0.29 11.0 18.0 0.37 10.7 18.0 1.2 1 0 0 1 1 1 0 Spore coat protein CotO MMR1 PF08505.10 CDI86379.1 - 0.53 10.5 9.5 0.63 10.3 9.5 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein TFB6 PF17110.5 CDI86379.1 - 0.58 9.9 4.6 0.81 9.4 4.6 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH V_ATPase_I PF01496.19 CDI86379.1 - 0.64 7.9 8.3 0.7 7.7 8.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ndc1_Nup PF09531.10 CDI86379.1 - 0.72 8.5 7.8 0.73 8.4 7.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Methyltransf_23 PF13489.6 CDI86379.1 - 1.2 9.0 5.9 2.4 7.9 5.9 1.6 1 1 0 1 1 1 0 Methyltransferase domain YjbH PF06082.11 CDI86379.1 - 1.6 7.5 11.7 1.7 7.3 11.7 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH GWT1 PF06423.12 CDI86379.1 - 1.6 8.8 2.9 3.8 7.6 2.9 1.6 1 1 0 1 1 1 0 GWT1 PBP_sp32 PF07222.12 CDI86379.1 - 1.7 8.1 16.2 2.4 7.5 16.2 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Connexin PF00029.19 CDI86379.1 - 1.9 8.2 11.1 2.8 7.6 11.0 1.4 1 1 0 1 1 1 0 Connexin MDM31_MDM32 PF08118.11 CDI86379.1 - 2.3 6.8 6.4 3.1 6.4 6.4 1.2 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Coilin_N PF15862.5 CDI86379.1 - 3 7.7 13.8 4.8 7.0 13.8 1.3 1 0 0 1 1 1 0 Coilin N-terminus DUF4770 PF15994.5 CDI86379.1 - 7.6 6.7 13.1 11 6.2 13.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) UPF0560 PF10577.9 CDI86379.1 - 8.1 4.8 16.9 10 4.5 16.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Med15 PF09606.10 CDI86379.1 - 9.1 4.8 32.9 10 4.7 32.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SR-25 PF10500.9 CDI86380.1 - 0.015 14.9 44.5 0.017 14.8 24.3 2.0 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein PI3K_1B_p101 PF10486.9 CDI86380.1 - 1.3 6.7 29.0 1.5 6.5 29.0 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF2339 PF10101.9 CDI86381.1 - 1 7.9 26.6 1.5 7.3 26.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) SARAF PF06682.12 CDI86382.1 - 0.0029 17.3 9.4 0.0034 17.1 9.4 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Serinc PF03348.15 CDI86382.1 - 0.19 10.6 6.2 0.19 10.6 6.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4746 PF15928.5 CDI86382.1 - 0.55 9.6 7.8 0.59 9.5 7.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Velvet PF11754.8 CDI86382.1 - 0.59 10.0 15.4 0.66 9.9 15.4 1.0 1 0 0 1 1 1 0 Velvet factor Neur_chan_memb PF02932.16 CDI86382.1 - 0.67 10.0 11.0 0.74 9.8 11.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region YjbH PF06082.11 CDI86382.1 - 0.85 8.4 14.9 0.9 8.3 14.9 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH V_ATPase_I PF01496.19 CDI86382.1 - 0.98 7.2 20.7 1.1 7.1 20.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DDHD PF02862.17 CDI86382.1 - 1.3 9.2 10.9 1.5 8.9 10.9 1.3 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 CDI86382.1 - 1.4 7.6 16.0 1.5 7.5 16.0 1.2 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 CDI86382.1 - 1.7 7.0 3.9 1.7 7.0 3.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PIP5K PF01504.18 CDI86382.1 - 1.7 7.8 9.6 1.8 7.7 9.6 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase ABC2_membrane_2 PF12679.7 CDI86382.1 - 2.1 7.6 5.5 2.9 7.1 5.5 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein O-antigen_lig PF13425.6 CDI86382.1 - 3 6.5 3.6 3.2 6.4 3.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CobT PF06213.12 CDI86382.1 - 3.4 7.0 20.5 3.8 6.8 20.5 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM60A PF15396.6 CDI86382.1 - 4.3 7.3 9.9 4.8 7.1 9.9 1.3 1 0 0 1 1 1 0 Protein Family FAM60A eIF-3_zeta PF05091.12 CDI86382.1 - 5.1 5.9 17.8 5.4 5.9 17.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CSG2 PF16965.5 CDI86382.1 - 6 5.7 8.9 6.5 5.6 8.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 CDI86382.1 - 8 5.4 11.4 8.7 5.3 11.4 1.2 1 0 0 1 1 1 0 CLN3 protein DUF2828 PF11443.8 CDI86382.1 - 9.2 4.2 15.3 9.7 4.1 15.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Afi1 PF07792.12 CDI86383.1 - 0.0083 16.6 6.5 0.0083 16.6 6.5 3.1 2 1 1 3 3 3 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Utp14 PF04615.13 CDI86383.1 - 1.1 7.7 43.6 1.4 7.4 43.6 1.1 1 0 0 1 1 1 0 Utp14 protein EPL1 PF10513.9 CDI86384.1 - 0.0098 16.3 6.7 0.0098 16.3 6.7 7.8 7 2 1 8 8 8 2 Enhancer of polycomb-like Tim54 PF11711.8 CDI86386.1 - 9.1e-05 21.4 11.9 9.1e-05 21.4 11.9 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 TCP PF03634.13 CDI86386.1 - 0.0055 17.3 14.9 0.0056 17.3 14.9 1.1 1 0 0 1 1 1 1 TCP family transcription factor CLN3 PF02487.17 CDI86386.1 - 0.0075 15.4 14.2 0.0081 15.2 14.2 1.0 1 0 0 1 1 1 1 CLN3 protein DDHD PF02862.17 CDI86386.1 - 0.0098 16.1 14.8 0.011 15.9 14.8 1.2 1 0 0 1 1 1 1 DDHD domain DUF913 PF06025.12 CDI86386.1 - 0.013 14.5 10.2 0.013 14.5 10.2 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3535 PF12054.8 CDI86386.1 - 0.014 14.7 19.8 0.017 14.4 19.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3535) DUF2126 PF09899.9 CDI86386.1 - 0.018 13.1 14.0 0.02 13.0 14.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) V_ATPase_I PF01496.19 CDI86386.1 - 0.027 12.4 22.3 0.029 12.3 22.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5308 PF17233.2 CDI86386.1 - 0.03 14.6 15.5 0.036 14.3 15.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) CPSF100_C PF13299.6 CDI86386.1 - 0.039 14.1 15.4 0.049 13.8 15.4 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SpoIIP PF07454.11 CDI86386.1 - 0.042 13.3 23.3 0.048 13.1 23.3 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) NPR3 PF03666.13 CDI86386.1 - 0.049 12.4 17.8 0.051 12.4 17.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Connexin PF00029.19 CDI86386.1 - 0.059 13.1 15.0 0.063 13.0 15.0 1.1 1 0 0 1 1 1 0 Connexin Pal1 PF08316.11 CDI86386.1 - 0.12 13.2 9.0 0.15 12.8 9.0 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein DUF4746 PF15928.5 CDI86386.1 - 0.13 11.6 14.4 0.15 11.4 14.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PIP5K PF01504.18 CDI86386.1 - 0.18 11.0 19.0 0.2 10.8 19.0 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase SLC12 PF03522.15 CDI86386.1 - 0.2 10.7 21.8 0.21 10.6 21.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 BORG_CEP PF14957.6 CDI86386.1 - 0.21 12.7 13.4 0.22 12.7 13.4 1.1 1 0 0 1 1 1 0 Cdc42 effector RR_TM4-6 PF06459.12 CDI86386.1 - 0.23 11.3 22.9 0.24 11.2 22.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 HemX PF04375.14 CDI86386.1 - 0.45 9.8 42.3 0.49 9.6 42.3 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase FAM176 PF14851.6 CDI86386.1 - 0.45 10.2 13.3 0.55 9.9 13.3 1.1 1 0 0 1 1 1 0 FAM176 family CSG2 PF16965.5 CDI86386.1 - 0.5 9.3 12.4 0.57 9.1 12.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator PAP2_3 PF14378.6 CDI86386.1 - 0.5 10.0 2.1 1.3 8.7 2.1 1.6 1 1 0 1 1 1 0 PAP2 superfamily SID-1_RNA_chan PF13965.6 CDI86386.1 - 0.67 8.3 10.9 0.71 8.2 10.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Ketoacyl-synt_2 PF13723.6 CDI86386.1 - 1 8.9 23.0 1.3 8.7 23.0 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain OATP PF03137.20 CDI86386.1 - 1.6 6.9 11.3 2.3 6.4 11.3 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family eIF-3_zeta PF05091.12 CDI86386.1 - 3.3 6.6 33.7 3.7 6.4 33.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Pex14_N PF04695.13 CDI86386.1 - 3.7 8.2 41.1 4.3 8.0 41.1 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Folate_carrier PF01770.18 CDI86386.1 - 4.2 6.0 13.5 5.4 5.6 13.5 1.1 1 0 0 1 1 1 0 Reduced folate carrier Scs3p PF10261.9 CDI86386.1 - 4.5 6.7 9.3 5.8 6.4 9.3 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM SARAF PF06682.12 CDI86386.1 - 4.7 6.8 22.7 5.5 6.5 22.7 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Velvet PF11754.8 CDI86386.1 - 4.9 7.0 23.7 5.3 6.9 23.7 1.1 1 0 0 1 1 1 0 Velvet factor MDM10 PF12519.8 CDI86386.1 - 5.4 5.8 23.4 6.1 5.6 23.4 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Tmp39 PF10271.9 CDI86386.1 - 5.4 5.9 7.4 5.7 5.8 7.4 1.0 1 0 0 1 1 1 0 Putative transmembrane protein Endostatin PF06482.11 CDI86386.1 - 5.8 6.3 24.1 6.4 6.1 24.1 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Membralin PF09746.9 CDI86386.1 - 6.1 5.8 17.2 6.5 5.7 17.2 1.0 1 0 0 1 1 1 0 Tumour-associated protein TFIIA PF03153.13 CDI86386.1 - 6.5 6.6 58.9 9.7 6.1 58.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Plasmodium_Vir PF05795.11 CDI86386.1 - 6.6 6.0 12.6 6.3 6.1 12.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein NEMP PF10225.9 CDI86386.1 - 8.9 5.9 10.5 11 5.6 10.5 1.1 1 0 0 1 1 1 0 NEMP family Peptidase_S15 PF02129.18 CDI86386.1 - 9.6 5.7 19.5 11 5.5 19.5 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Afi1 PF07792.12 CDI86386.1 - 10 6.6 25.9 13 6.3 25.9 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking BAF1_ABF1 PF04684.13 CDI86387.1 - 0.009 15.1 15.1 0.01 14.9 15.1 1.0 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor RskA PF10099.9 CDI86388.1 - 0.00072 19.9 15.0 0.00072 19.9 15.0 7.2 3 1 3 6 6 6 3 Anti-sigma-K factor rskA NAM-associated PF14303.6 CDI86388.1 - 0.0062 17.3 1.0 0.0062 17.3 1.0 6.5 5 4 0 5 5 5 1 No apical meristem-associated C-terminal domain Apt1 PF10351.9 CDI86388.1 - 0.063 12.1 45.0 0.045 12.6 12.5 3.3 3 0 0 3 3 3 0 Golgi-body localisation protein domain Med15 PF09606.10 CDI86389.1 - 0.13 10.9 73.1 0.15 10.7 73.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF726 PF05277.12 CDI86389.1 - 0.24 10.3 2.0 0.29 10.0 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) SLC12 PF03522.15 CDI86389.1 - 0.78 8.7 34.0 0.82 8.6 34.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Exonuc_VII_L PF02601.15 CDI86389.1 - 2.6 7.5 39.1 3.2 7.2 39.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit PAT1 PF09770.9 CDI86389.1 - 3.4 5.8 63.0 3.7 5.7 63.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDC45 PF02724.14 CDI86389.1 - 4.5 5.5 30.3 4.8 5.4 30.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Caldesmon PF02029.15 CDI86389.1 - 4.7 5.9 42.0 5.3 5.7 42.0 1.1 1 0 0 1 1 1 0 Caldesmon DUF5585 PF17823.1 CDI86389.1 - 5.3 5.9 29.2 6.8 5.5 29.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Asp-B-Hydro_N PF05279.11 CDI86389.1 - 8.9 6.3 30.4 9.9 6.1 30.4 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Rsc14 PF08586.10 CDI86390.1 - 0.41 11.5 13.6 1.3 9.9 3.6 3.2 3 0 0 3 3 3 0 RSC complex, Rsc14/Ldb7 subunit RskA PF10099.9 CDI86390.1 - 3.8 7.8 35.3 0.017 15.5 14.9 2.3 1 1 1 2 2 2 0 Anti-sigma-K factor rskA NT-C2 PF10358.9 CDI86392.1 - 0.00032 20.4 0.0 0.68 9.6 0.0 2.5 2 0 0 2 2 2 2 N-terminal C2 in EEIG1 and EHBP1 proteins Pox_A_type_inc PF04508.12 CDI86392.1 - 0.45 10.5 3.2 9.5 6.3 0.2 3.9 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Spt20 PF12090.8 CDI86393.1 - 0.0002 21.1 48.9 0.036 13.7 35.4 2.2 2 0 0 2 2 2 2 Spt20 family RskA PF10099.9 CDI86393.1 - 0.0021 18.4 1.0 0.0021 18.4 1.0 3.4 1 1 1 2 2 1 1 Anti-sigma-K factor rskA RRP36 PF06102.12 CDI86393.1 - 0.0021 18.0 14.2 0.0047 16.9 8.2 2.2 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 eIF-3_zeta PF05091.12 CDI86393.1 - 0.0035 16.4 18.6 0.005 15.9 11.2 2.0 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Suf PF05843.14 CDI86393.1 - 0.0046 17.0 15.0 0.0084 16.1 6.9 2.2 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) Band_3_cyto PF07565.13 CDI86393.1 - 0.0058 16.5 5.6 0.014 15.2 1.9 2.2 2 0 0 2 2 2 1 Band 3 cytoplasmic domain MecA PF05389.12 CDI86393.1 - 0.0063 16.2 7.4 0.085 12.5 4.5 2.2 2 0 0 2 2 2 1 Negative regulator of genetic competence (MecA) TFB6 PF17110.5 CDI86393.1 - 0.01 15.6 2.2 0.042 13.6 0.7 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF2722 PF10846.8 CDI86393.1 - 0.012 14.6 39.7 0.018 14.0 24.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) PEX11 PF05648.14 CDI86393.1 - 0.013 15.0 7.2 0.84 9.1 3.8 2.3 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) PTPRCAP PF15713.5 CDI86393.1 - 0.017 15.5 6.3 0.017 15.5 6.3 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated CNDH2_M PF16869.5 CDI86393.1 - 0.02 15.6 8.4 0.13 12.9 4.8 2.4 2 0 0 2 2 2 0 PF16858 Peroxin-13_N PF04088.13 CDI86393.1 - 0.02 15.2 6.9 0.17 12.1 3.6 2.3 2 0 0 2 2 2 0 Peroxin 13, N-terminal region EPL1 PF10513.9 CDI86393.1 - 0.02 15.3 13.1 0.027 14.8 5.1 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF5327 PF17261.2 CDI86393.1 - 0.021 15.6 20.1 0.18 12.6 12.3 2.9 3 0 0 3 3 2 0 Family of unknown function (DUF5327) DUF4834 PF16118.5 CDI86393.1 - 0.021 15.8 19.6 0.037 15.0 10.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RED_N PF07808.13 CDI86393.1 - 0.022 14.3 18.0 0.13 11.9 11.7 2.2 2 0 0 2 2 2 0 RED-like protein N-terminal region Eapp_C PF10238.9 CDI86393.1 - 0.023 14.8 11.3 0.02 15.0 4.3 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein CPSF100_C PF13299.6 CDI86393.1 - 0.024 14.8 9.5 0.051 13.8 5.2 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal PAT1 PF09770.9 CDI86393.1 - 0.025 12.9 20.9 0.018 13.3 13.7 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 AAA_23 PF13476.6 CDI86393.1 - 0.037 14.5 14.9 0.19 12.2 8.4 2.3 2 0 0 2 2 2 0 AAA domain Herpes_Helicase PF02689.14 CDI86393.1 - 0.037 12.0 5.2 0.061 11.3 5.2 1.3 1 0 0 1 1 1 0 Helicase ABC2_membrane_2 PF12679.7 CDI86393.1 - 0.038 13.3 6.2 0.024 13.9 2.3 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein Afi1 PF07792.12 CDI86393.1 - 0.041 14.4 10.7 0.17 12.4 7.3 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Connexin PF00029.19 CDI86393.1 - 0.053 13.3 7.2 0.26 11.0 5.4 2.0 2 0 0 2 2 2 0 Connexin FAM91_C PF14648.6 CDI86393.1 - 0.061 12.2 4.0 0.018 13.9 0.7 1.7 2 0 0 2 2 2 0 FAM91 C-terminus SLC12 PF03522.15 CDI86393.1 - 0.069 12.2 8.5 0.063 12.3 4.6 2.0 2 0 0 2 2 2 0 Solute carrier family 12 FAM60A PF15396.6 CDI86393.1 - 0.074 13.0 3.6 0.29 11.1 2.0 2.1 2 0 0 2 2 2 0 Protein Family FAM60A EOS1 PF12326.8 CDI86393.1 - 0.076 12.9 2.4 0.49 10.3 1.5 2.1 2 0 0 2 2 2 0 N-glycosylation protein SpoIIP PF07454.11 CDI86393.1 - 0.076 12.5 12.4 0.057 12.9 6.9 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) FAM176 PF14851.6 CDI86393.1 - 0.1 12.2 8.4 0.17 11.5 3.3 2.2 2 0 0 2 2 2 0 FAM176 family MMR1 PF08505.10 CDI86393.1 - 0.12 12.7 16.3 0.034 14.4 8.0 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein CLN3 PF02487.17 CDI86393.1 - 0.18 10.8 9.4 0.089 11.8 5.0 2.0 2 0 0 2 2 2 0 CLN3 protein DUF4808 PF16066.5 CDI86393.1 - 0.19 12.3 6.8 2.5 8.7 2.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4808) V_ATPase_I PF01496.19 CDI86393.1 - 0.2 9.6 14.4 0.11 10.3 9.1 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family SID-1_RNA_chan PF13965.6 CDI86393.1 - 0.2 10.0 5.2 0.041 12.3 2.1 1.4 2 0 0 2 2 1 0 dsRNA-gated channel SID-1 Cytochrom_B_N_2 PF13631.6 CDI86393.1 - 0.21 11.6 0.2 0.59 10.1 0.0 1.8 2 0 0 2 2 1 0 Cytochrome b(N-terminal)/b6/petB DUF913 PF06025.12 CDI86393.1 - 0.23 10.4 6.3 0.22 10.4 4.0 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Mem_trans PF03547.18 CDI86393.1 - 0.25 9.7 1.9 0.42 9.0 1.9 1.3 1 0 0 1 1 1 0 Membrane transport protein Rxt3 PF08642.10 CDI86393.1 - 0.25 12.1 5.4 0.9 10.3 2.6 2.4 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 OATP PF03137.20 CDI86393.1 - 0.31 9.3 6.5 0.14 10.4 2.6 1.9 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF1980 PF09323.10 CDI86393.1 - 0.37 10.7 5.9 1.1 9.2 3.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF4518 PF15008.6 CDI86393.1 - 0.38 9.9 12.0 0.45 9.6 7.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) DUF3381 PF11861.8 CDI86393.1 - 0.42 10.4 20.9 0.6 9.9 12.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Hid1 PF12722.7 CDI86393.1 - 0.43 8.6 8.9 0.073 11.2 4.6 1.7 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein ALMT PF11744.8 CDI86393.1 - 0.47 9.2 8.1 0.29 9.9 4.7 1.9 2 0 0 2 2 2 0 Aluminium activated malate transporter Peptidase_S49_N PF08496.10 CDI86393.1 - 0.5 10.4 12.7 0.38 10.8 5.0 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal UPF0239 PF06783.11 CDI86393.1 - 0.61 10.3 6.0 1 9.6 1.9 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) UPF0524 PF15823.5 CDI86393.1 - 0.62 9.4 8.0 0.03 13.7 1.0 2.1 2 0 0 2 2 2 0 UPF0524 of C3orf70 Pet20 PF08692.10 CDI86393.1 - 0.65 10.7 7.4 4.4 8.0 4.5 2.4 2 0 0 2 2 2 0 Mitochondrial protein Pet20 BAT2_N PF07001.11 CDI86393.1 - 0.7 10.3 26.8 0.73 10.3 16.2 3.3 3 0 0 3 3 3 0 BAT2 N-terminus MPM1 PF17234.2 CDI86393.1 - 0.79 10.0 17.6 0.36 11.1 9.4 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Mak10 PF04112.13 CDI86393.1 - 0.86 9.1 9.3 0.37 10.3 5.1 2.1 2 0 0 2 2 2 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase MDM31_MDM32 PF08118.11 CDI86393.1 - 0.98 8.0 6.9 1.5 7.4 4.9 1.9 2 0 0 2 2 2 0 Yeast mitochondrial distribution and morphology (MDM) proteins FHIPEP PF00771.20 CDI86393.1 - 1 7.7 13.1 0.32 9.4 7.7 2.2 2 0 0 2 2 2 0 FHIPEP family RPA43_OB PF17875.1 CDI86393.1 - 1 10.0 9.4 3.5 8.3 5.2 2.3 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I PRC2_HTH_1 PF18118.1 CDI86393.1 - 1.3 9.9 9.8 3.3 8.6 5.2 2.4 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Conotoxin PF02950.17 CDI86393.1 - 1.3 10.1 10.3 6.4 7.9 3.7 2.8 2 0 0 2 2 2 0 Conotoxin Serinc PF03348.15 CDI86393.1 - 1.4 7.8 6.9 0.29 10.0 3.1 1.7 2 0 0 2 2 2 0 Serine incorporator (Serinc) TERB2 PF15101.6 CDI86393.1 - 1.6 8.8 27.6 3.6 7.6 18.6 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 EIIBC-GUT_N PF03612.14 CDI86393.1 - 1.8 8.3 15.7 1.9 8.2 10.9 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus BRF1 PF07741.13 CDI86393.1 - 1.9 8.9 17.8 3 8.2 10.1 2.5 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Plasmodium_Vir PF05795.11 CDI86393.1 - 1.9 7.8 5.8 1.3 8.3 2.8 2.0 2 0 0 2 2 2 0 Plasmodium vivax Vir protein G0-G1_switch_2 PF15103.6 CDI86393.1 - 1.9 8.9 10.3 17 5.9 7.2 2.5 2 0 0 2 2 2 0 G0/G1 switch protein 2 Draxin PF15550.6 CDI86393.1 - 2.1 8.2 11.1 0.5 10.2 2.5 2.1 2 0 0 2 2 2 0 Draxin RMP PF14996.6 CDI86393.1 - 2.1 8.6 14.8 6.6 6.9 0.3 2.3 2 0 0 2 2 2 0 Retinal Maintenance Mif2_N PF15624.6 CDI86393.1 - 2.2 9.0 10.0 1 10.1 5.8 2.3 2 0 0 2 2 2 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal DUF4770 PF15994.5 CDI86393.1 - 2.3 8.4 18.2 3.5 7.8 10.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) YABBY PF04690.13 CDI86393.1 - 2.5 8.7 10.8 2.8 8.5 5.8 2.3 2 0 0 2 2 2 0 YABBY protein Rsc14 PF08586.10 CDI86393.1 - 2.6 8.9 10.7 14 6.5 5.8 2.3 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit Tim54 PF11711.8 CDI86393.1 - 2.7 6.7 11.8 1.5 7.6 7.1 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DivIC PF04977.15 CDI86393.1 - 2.8 7.8 35.7 2.5 7.9 19.5 2.6 2 0 0 2 2 2 0 Septum formation initiator NEMP PF10225.9 CDI86393.1 - 2.9 7.5 7.5 4.8 6.8 3.2 2.1 2 0 0 2 2 2 0 NEMP family Baculo_PP31 PF05311.11 CDI86393.1 - 3.1 7.2 12.3 0.8 9.1 7.1 2.0 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) CytB6-F_Fe-S PF08802.10 CDI86393.1 - 3.4 7.8 0.0 3.4 7.8 0.0 4.1 3 1 1 4 4 1 0 Cytochrome B6-F complex Fe-S subunit Rpp20 PF12328.8 CDI86393.1 - 4.1 7.4 16.4 2.1 8.3 8.3 2.3 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P RNA_pol_Rbc25 PF08292.12 CDI86393.1 - 4.1 7.6 14.5 0.45 10.8 6.3 2.2 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 PH_4 PF15404.6 CDI86393.1 - 4.4 7.1 15.4 0.85 9.4 9.1 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain Folate_carrier PF01770.18 CDI86393.1 - 4.9 5.8 8.8 2.1 7.0 5.6 1.8 2 0 0 2 2 2 0 Reduced folate carrier Sec62 PF03839.16 CDI86393.1 - 5.1 6.5 11.4 1.5 8.3 6.3 2.0 2 0 0 2 2 2 0 Translocation protein Sec62 Sporozoite_P67 PF05642.11 CDI86393.1 - 5.3 5.0 8.3 3.8 5.5 6.4 1.6 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DUF702 PF05142.12 CDI86393.1 - 5.3 7.5 21.4 2.8 8.4 11.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Thg1C PF14413.6 CDI86393.1 - 5.3 7.2 14.9 15 5.8 10.6 2.3 2 0 0 2 2 2 0 Thg1 C terminal domain NST1 PF13945.6 CDI86393.1 - 5.4 7.1 24.6 2.7 8.0 14.6 2.3 2 0 0 2 2 2 0 Salt tolerance down-regulator MCU PF04678.13 CDI86393.1 - 5.4 7.1 14.6 1.1 9.3 5.8 2.7 3 0 0 3 3 2 0 Mitochondrial calcium uniporter TMEM51 PF15345.6 CDI86393.1 - 5.9 6.7 19.5 1.3 8.8 10.6 2.3 2 0 0 2 2 2 0 Transmembrane protein 51 ATAD4 PF15321.6 CDI86393.1 - 6.2 8.2 12.1 12 7.3 7.0 2.4 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 CTU2 PF10288.9 CDI86393.1 - 8 6.7 15.1 36 4.6 10.6 2.5 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 FliP PF00813.20 CDI86393.1 - 8.3 6.2 7.5 3.1 7.6 2.0 2.2 2 0 0 2 2 2 0 FliP family Scs3p PF10261.9 CDI86393.1 - 8.5 5.8 6.0 3.5 7.1 2.1 2.0 2 0 0 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM ORC_WH_C PF18137.1 CDI86393.1 - 8.6 6.4 15.4 42 4.2 0.1 2.3 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal DUF4199 PF13858.6 CDI86393.1 - 9 6.7 16.6 5.6 7.3 8.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) Pex14_N PF04695.13 CDI86394.1 - 3.3e-13 50.6 7.1 3.3e-13 50.6 7.1 2.2 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2722 PF10846.8 CDI86394.1 - 0.0088 15.0 17.7 0.0088 15.0 17.7 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI86394.1 - 0.014 15.0 50.9 0.11 12.1 27.7 2.1 2 0 0 2 2 2 0 Spt20 family Adeno_PIX PF03955.14 CDI86394.1 - 0.047 13.9 2.8 0.07 13.3 2.8 1.2 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) DUF494 PF04361.13 CDI86394.1 - 0.048 13.5 1.6 0.048 13.5 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF494) FGE-sulfatase PF03781.16 CDI86394.1 - 0.2 11.2 10.9 0.25 10.9 10.9 1.0 1 0 0 1 1 1 0 Sulfatase-modifying factor enzyme 1 RskA PF10099.9 CDI86394.1 - 0.38 11.0 25.0 3.9 7.7 24.4 2.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA BAF1_ABF1 PF04684.13 CDI86394.1 - 0.4 9.7 16.1 0.55 9.2 16.1 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Tim54 PF11711.8 CDI86394.1 - 0.97 8.1 13.8 1.2 7.8 13.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 ATAD4 PF15321.6 CDI86394.1 - 1.1 10.7 11.4 1.1 10.6 3.1 2.2 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Presenilin PF01080.17 CDI86394.1 - 1.3 7.7 18.1 2 7.1 18.1 1.2 1 0 0 1 1 1 0 Presenilin Sin_N PF04801.13 CDI86394.1 - 2.8 7.1 27.5 4.1 6.5 27.5 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region AIF_C PF14721.6 CDI86394.1 - 3.8 7.9 13.2 0.63 10.4 4.3 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF1764 PF08576.10 CDI86394.1 - 3.8 8.5 16.0 4.2 8.3 6.0 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Rxt3 PF08642.10 CDI86394.1 - 4.4 8.1 11.9 6.4 7.6 4.6 2.1 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 MAPEG PF01124.18 CDI86394.1 - 5.9 6.8 8.3 0.74 9.7 3.7 1.7 1 1 1 2 2 2 0 MAPEG family Maf1 PF09174.10 CDI86394.1 - 6 7.0 10.4 1.3 9.1 2.4 2.0 2 0 0 2 2 2 0 Maf1 regulator Ndc1_Nup PF09531.10 CDI86394.1 - 6.1 5.4 23.3 7.2 5.2 23.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4834 PF16118.5 CDI86394.1 - 6.5 7.8 22.2 5.2 8.1 11.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EF-hand_1 PF00036.32 CDI86395.1 - 1.9e-05 23.9 0.0 0.00073 18.9 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 CDI86395.1 - 4.5e-05 23.0 0.2 0.0005 19.8 0.0 2.8 4 0 0 4 4 4 1 EF-hand domain EF-hand_7 PF13499.6 CDI86395.1 - 0.01 16.3 0.1 0.09 13.2 0.0 2.6 2 2 0 2 2 2 1 EF-hand domain pair GSCFA PF08885.11 CDI86395.1 - 0.12 12.0 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 GSCFA family RCDG1 PF15725.5 CDI86396.1 - 4.4e-05 23.8 0.2 4.4e-05 23.8 0.2 3.2 4 0 0 4 4 4 1 Renal cancer differentiation gene 1 protein Lin-8 PF03353.15 CDI86397.1 - 0.46 10.0 10.5 0.62 9.6 10.5 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RskA PF10099.9 CDI86400.1 - 0.00012 22.5 9.7 0.00015 22.2 9.7 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Suf PF05843.14 CDI86400.1 - 0.011 15.8 9.4 0.011 15.8 9.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF5349 PF17298.2 CDI86400.1 - 0.023 14.5 9.3 0.025 14.3 9.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5349) Spt20 PF12090.8 CDI86400.1 - 0.024 14.2 26.9 0.026 14.1 26.9 1.1 1 0 0 1 1 1 0 Spt20 family TMEM65 PF10507.9 CDI86400.1 - 0.043 13.7 1.3 0.057 13.4 1.3 1.1 1 0 0 1 1 1 0 Transmembrane protein 65 Glt_symporter PF03616.14 CDI86400.1 - 0.068 11.8 0.9 0.075 11.7 0.9 1.0 1 0 0 1 1 1 0 Sodium/glutamate symporter AIF_C PF14721.6 CDI86400.1 - 0.069 13.5 2.3 0.068 13.5 2.3 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4834 PF16118.5 CDI86400.1 - 0.07 14.1 8.4 0.084 13.9 8.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2367 PF10164.9 CDI86400.1 - 0.072 13.6 4.1 0.079 13.5 4.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) ORC_WH_C PF18137.1 CDI86400.1 - 0.081 13.0 6.2 0.091 12.8 6.2 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Helicase_RecD PF05127.14 CDI86400.1 - 0.086 12.7 5.2 0.12 12.2 5.2 1.2 1 0 0 1 1 1 0 Helicase Orf78 PF06024.12 CDI86400.1 - 0.087 13.1 1.3 0.093 13.0 1.3 1.2 1 0 0 1 1 1 0 Orf78 (ac78) TMEM51 PF15345.6 CDI86400.1 - 0.094 12.5 6.5 0.093 12.6 6.5 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 DUF2407 PF10302.9 CDI86400.1 - 0.11 13.1 4.0 0.16 12.6 4.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain TFIIA PF03153.13 CDI86400.1 - 0.11 12.5 24.4 0.12 12.4 24.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI86400.1 - 0.13 10.9 22.9 0.13 10.9 22.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal EIF4E-T PF10477.9 CDI86400.1 - 0.16 10.7 11.6 0.18 10.6 11.6 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E EIIBC-GUT_N PF03612.14 CDI86400.1 - 0.16 11.7 4.7 0.17 11.6 4.7 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus VKG_Carbox PF05090.14 CDI86400.1 - 0.2 10.5 0.8 0.2 10.4 0.8 1.0 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase EOS1 PF12326.8 CDI86400.1 - 0.22 11.4 1.6 0.22 11.4 1.6 1.1 1 0 0 1 1 1 0 N-glycosylation protein DUF775 PF05603.12 CDI86400.1 - 0.23 11.0 7.6 0.24 10.9 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) eIF-3_zeta PF05091.12 CDI86400.1 - 0.26 10.2 10.8 0.26 10.2 10.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TERB2 PF15101.6 CDI86400.1 - 0.29 11.2 9.6 0.3 11.1 9.6 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SpoIIP PF07454.11 CDI86400.1 - 0.33 10.4 6.9 0.35 10.3 6.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Band_3_cyto PF07565.13 CDI86400.1 - 0.46 10.2 4.7 0.46 10.2 4.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Kei1 PF08552.11 CDI86400.1 - 0.51 10.2 5.1 0.55 10.1 5.1 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 SprA-related PF12118.8 CDI86400.1 - 0.65 9.1 19.9 0.74 8.9 19.9 1.0 1 0 0 1 1 1 0 SprA-related family Presenilin PF01080.17 CDI86400.1 - 0.72 8.6 8.5 0.7 8.6 8.5 1.0 1 0 0 1 1 1 0 Presenilin DDHD PF02862.17 CDI86400.1 - 0.81 9.8 7.6 0.86 9.7 7.6 1.0 1 0 0 1 1 1 0 DDHD domain DUF4175 PF13779.6 CDI86400.1 - 0.84 7.5 19.7 0.8 7.5 19.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Coilin_N PF15862.5 CDI86400.1 - 0.96 9.2 10.2 1.2 8.9 10.2 1.2 1 0 0 1 1 1 0 Coilin N-terminus DUF4770 PF15994.5 CDI86400.1 - 0.98 9.6 11.1 1.3 9.2 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Neur_chan_memb PF02932.16 CDI86400.1 - 1.1 9.3 3.9 1.1 9.3 3.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Roughex PF06020.11 CDI86400.1 - 1.1 8.3 9.6 1 8.4 9.6 1.1 1 0 0 1 1 1 0 Drosophila roughex protein UPF0560 PF10577.9 CDI86400.1 - 1.1 7.6 13.1 1.1 7.6 13.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF1980 PF09323.10 CDI86400.1 - 1.3 8.9 5.5 1.4 8.8 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF2232 PF09991.9 CDI86400.1 - 2.1 7.5 3.3 2.3 7.3 3.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DUF4407 PF14362.6 CDI86400.1 - 2.8 7.2 14.1 3.4 6.9 14.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ndc1_Nup PF09531.10 CDI86400.1 - 3.5 6.2 8.1 3.7 6.1 8.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAM199X PF15814.5 CDI86400.1 - 3.9 6.5 9.0 4.7 6.2 9.0 1.0 1 0 0 1 1 1 0 Protein family FAM199X Chorion_3 PF05387.11 CDI86400.1 - 4.6 6.8 14.2 5.3 6.6 14.2 1.0 1 0 0 1 1 1 0 Chorion family 3 DUF1360 PF07098.11 CDI86400.1 - 5.2 7.1 5.8 0.61 10.1 1.8 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF1360) DUF2722 PF10846.8 CDI86401.1 - 2.6e-06 26.7 17.9 7.2e-05 21.9 6.6 9.7 6 3 3 9 9 9 3 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI86401.1 - 9e-05 22.2 4.4 9e-05 22.2 4.4 9.2 6 2 2 8 8 8 3 Spt20 family RskA PF10099.9 CDI86401.1 - 0.0002 21.7 20.2 0.0002 21.7 20.2 12.1 4 3 4 9 9 9 3 Anti-sigma-K factor rskA UPF0564 PF10595.9 CDI86401.1 - 0.0015 17.6 21.2 0.0015 17.6 21.2 6.4 6 1 0 6 6 6 2 Uncharacterised protein family UPF0564 N6_N4_Mtase PF01555.18 CDI86401.1 - 0.023 14.4 0.6 25 4.5 0.0 4.0 3 1 0 3 3 3 0 DNA methylase Eapp_C PF10238.9 CDI86401.1 - 0.024 14.7 0.9 0.024 14.7 0.9 8.0 6 2 0 6 6 6 0 E2F-associated phosphoprotein SARAF PF06682.12 CDI86401.1 - 0.038 13.6 0.0 0.038 13.6 0.0 6.0 4 1 0 5 5 5 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4834 PF16118.5 CDI86401.1 - 0.24 12.4 0.1 0.24 12.4 0.1 9.4 6 2 1 7 7 7 0 Domain of unknown function (DUF4834) Plasmodium_Vir PF05795.11 CDI86401.1 - 1.1 8.5 0.0 1.1 8.5 0.0 4.7 3 1 0 3 3 3 0 Plasmodium vivax Vir protein Spt20 PF12090.8 CDI86402.1 - 0.00041 20.0 17.6 0.00042 20.0 17.6 1.2 1 0 0 1 1 1 1 Spt20 family Wzz PF02706.15 CDI86402.1 - 0.0026 18.0 3.6 0.0026 18.0 3.6 1.5 2 0 0 2 2 1 1 Chain length determinant protein DUF3824 PF12868.7 CDI86402.1 - 0.0074 17.0 1.3 0.0074 17.0 1.3 2.2 2 0 0 2 2 2 1 Domain of unknwon function (DUF3824) TFIIA PF03153.13 CDI86402.1 - 0.012 15.7 26.3 0.012 15.6 26.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI86402.1 - 0.039 14.2 28.1 0.06 13.6 28.1 1.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Med3 PF11593.8 CDI86402.1 - 0.04 13.1 32.1 0.046 12.9 32.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FHIPEP PF00771.20 CDI86402.1 - 0.045 12.2 3.9 0.05 12.1 3.9 1.0 1 0 0 1 1 1 0 FHIPEP family Bac_luciferase PF00296.20 CDI86402.1 - 0.074 12.5 10.1 0.086 12.2 10.1 1.0 1 0 0 1 1 1 0 Luciferase-like monooxygenase eIF-3_zeta PF05091.12 CDI86402.1 - 0.089 11.7 8.8 0.096 11.6 8.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Pex14_N PF04695.13 CDI86402.1 - 0.091 13.4 17.9 0.13 12.9 17.9 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4834 PF16118.5 CDI86402.1 - 0.14 13.1 7.0 0.21 12.6 7.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Suf PF05843.14 CDI86402.1 - 0.18 11.7 14.2 0.21 11.6 14.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Connexin PF00029.19 CDI86402.1 - 0.24 11.1 1.5 0.27 11.0 1.5 1.1 1 0 0 1 1 1 0 Connexin FAM199X PF15814.5 CDI86402.1 - 0.29 10.2 7.7 0.34 9.9 7.7 1.0 1 0 0 1 1 1 0 Protein family FAM199X Baculo_PP31 PF05311.11 CDI86402.1 - 0.3 10.5 6.9 0.32 10.4 6.9 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Nop53 PF07767.11 CDI86402.1 - 0.53 9.6 12.2 0.65 9.3 12.2 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Coilin_N PF15862.5 CDI86402.1 - 0.6 9.9 8.6 0.88 9.4 8.6 1.3 1 0 0 1 1 1 0 Coilin N-terminus THOC2_N PF16134.5 CDI86402.1 - 0.63 8.6 7.8 0.76 8.3 7.8 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus OATP PF03137.20 CDI86402.1 - 0.8 7.9 1.9 0.89 7.8 1.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Hydin_ADK PF17213.3 CDI86402.1 - 0.9 9.8 9.2 1.1 9.5 9.2 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain CLN3 PF02487.17 CDI86402.1 - 1 8.3 1.9 1 8.4 1.9 1.1 1 0 0 1 1 1 0 CLN3 protein NUDE_C PF04880.13 CDI86402.1 - 1.1 9.7 9.9 1.4 9.4 9.9 1.1 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region ST7 PF04184.12 CDI86402.1 - 1.4 7.3 4.9 1.6 7.1 4.9 1.0 1 0 0 1 1 1 0 ST7 protein Neur_chan_memb PF02932.16 CDI86402.1 - 1.4 8.9 5.7 1.6 8.7 5.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EOS1 PF12326.8 CDI86402.1 - 1.4 8.8 3.1 1.6 8.6 3.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein Serinc PF03348.15 CDI86402.1 - 1.7 7.5 3.2 1.8 7.4 3.2 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) RR_TM4-6 PF06459.12 CDI86402.1 - 2.5 7.9 7.8 2.9 7.7 7.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI86402.1 - 2.9 6.0 19.0 3.2 5.9 19.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI86402.1 - 3.6 4.6 10.4 3.9 4.5 10.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ndc1_Nup PF09531.10 CDI86402.1 - 4.4 5.9 9.9 4.4 5.9 9.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 CDI86402.1 - 4.5 5.9 11.5 5.1 5.8 11.5 1.1 1 0 0 1 1 1 0 Presenilin DUF2722 PF10846.8 CDI86403.1 - 0.0062 15.5 10.0 0.0062 15.5 10.0 3.1 3 0 0 3 3 3 3 Protein of unknown function (DUF2722) Nuf2 PF03800.14 CDI86403.1 - 0.11 12.6 0.0 0.11 12.6 0.0 2.9 4 0 0 4 4 4 0 Nuf2 family SR-25 PF10500.9 CDI86403.1 - 0.65 9.6 22.1 0.063 12.9 12.4 2.5 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein YbgS PF13985.6 CDI86403.1 - 7.6 6.8 7.9 0.71 10.2 0.7 2.3 2 0 0 2 2 2 0 YbgS-like protein SR-25 PF10500.9 CDI86404.1 - 5.6e-07 29.4 78.4 6.8e-06 25.9 20.7 3.1 3 0 0 3 3 3 2 Nuclear RNA-splicing-associated protein PIP5K PF01504.18 CDI86404.1 - 0.0006 19.1 6.0 0.0006 19.1 6.0 3.8 3 1 0 3 3 3 1 Phosphatidylinositol-4-phosphate 5-Kinase COX14 PF14880.6 CDI86405.1 - 1.6e-07 31.0 0.5 1.6e-07 31.0 0.5 5.4 3 2 0 3 3 1 1 Cytochrome oxidase c assembly SR-25 PF10500.9 CDI86405.1 - 1.7e-05 24.6 16.0 1.7e-05 24.6 16.0 2.1 1 1 1 2 2 1 1 Nuclear RNA-splicing-associated protein CCSAP PF15748.5 CDI86405.1 - 0.0087 16.3 36.6 0.011 16.0 36.6 1.1 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated DUF4746 PF15928.5 CDI86405.1 - 0.097 12.1 14.6 0.26 10.7 14.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4746) Rrn6 PF10214.9 CDI86405.1 - 0.18 10.2 37.6 0.24 9.9 37.6 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor V_ATPase_I PF01496.19 CDI86405.1 - 0.32 8.9 26.8 0.39 8.6 26.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RAP1 PF07218.11 CDI86405.1 - 0.68 8.1 3.3 0.82 7.9 3.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF572 PF04502.13 CDI86405.1 - 0.84 9.2 29.2 1.2 8.7 29.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Cytochrom_B558a PF05038.13 CDI86405.1 - 1 8.9 3.5 1.9 8.0 0.0 2.2 2 0 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit GREB1 PF15782.5 CDI86405.1 - 1.6 5.8 34.6 2 5.4 34.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PAT1 PF09770.9 CDI86405.1 - 2.5 6.3 51.7 2.8 6.1 51.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 XRN_M PF17846.1 CDI86405.1 - 4.4 6.1 20.7 4.8 6.0 20.7 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Exonuc_VII_L PF02601.15 CDI86405.1 - 5.3 6.5 35.2 6.1 6.3 35.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit ALMT PF11744.8 CDI86405.1 - 6.9 5.4 28.8 8.7 5.1 28.8 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Coatomer_g_Cpla PF16381.5 CDI86406.1 - 7.8e-09 35.7 2.3 7.4e-07 29.3 0.2 3.4 2 1 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform SR-25 PF10500.9 CDI86406.1 - 7.9e-05 22.4 12.2 7.9e-05 22.4 12.2 7.1 4 1 2 7 7 7 2 Nuclear RNA-splicing-associated protein SARAF PF06682.12 CDI86406.1 - 0.0042 16.8 1.0 0.0042 16.8 1.0 6.3 3 2 3 6 6 6 2 SOCE-associated regulatory factor of calcium homoeostasis ATP-synt_J PF04911.12 CDI86406.1 - 2.1 8.0 5.1 0.53 9.9 0.1 2.7 2 0 0 2 2 2 0 ATP synthase j chain DUF521 PF04412.13 CDI86408.1 - 0.08 11.6 4.0 0.084 11.6 4.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Spt20 PF12090.8 CDI86408.1 - 0.29 10.7 18.4 0.28 10.8 18.4 1.1 1 0 0 1 1 1 0 Spt20 family NEMP PF10225.9 CDI86408.1 - 0.59 9.8 2.6 0.59 9.7 2.6 1.0 1 0 0 1 1 1 0 NEMP family RskA PF10099.9 CDI86408.1 - 1.2 9.4 20.0 1.8 8.8 20.0 1.3 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF2232 PF09991.9 CDI86408.1 - 3.3 6.8 6.1 3.7 6.7 6.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) R_equi_Vir PF05526.11 CDI86408.1 - 8.1 6.3 9.1 9.4 6.1 9.1 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein RR_TM4-6 PF06459.12 CDI86409.1 - 0.014 15.3 4.3 0.017 14.9 4.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI86409.1 - 0.028 13.2 5.1 0.037 12.8 5.1 1.3 1 0 0 1 1 1 0 Presenilin DUF5327 PF17261.2 CDI86409.1 - 0.043 14.6 14.2 0.33 11.7 7.2 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5327) DUF4484 PF14831.6 CDI86409.1 - 0.051 13.6 6.8 0.071 13.1 6.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) CSG2 PF16965.5 CDI86409.1 - 0.074 12.0 4.7 0.097 11.6 4.7 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2828 PF11443.8 CDI86409.1 - 0.13 10.3 7.0 0.18 9.9 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Spt20 PF12090.8 CDI86409.1 - 0.17 11.5 33.0 1 8.9 18.4 2.2 2 0 0 2 2 2 0 Spt20 family FAM60A PF15396.6 CDI86409.1 - 0.17 11.8 1.7 0.24 11.4 1.7 1.3 1 0 0 1 1 1 0 Protein Family FAM60A V_ATPase_I PF01496.19 CDI86409.1 - 0.29 9.0 6.4 0.33 8.8 6.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4050 PF13259.6 CDI86409.1 - 0.35 11.2 6.2 0.78 10.0 6.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) PIP5K PF01504.18 CDI86409.1 - 0.36 10.0 3.6 0.48 9.6 3.6 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Neur_chan_memb PF02932.16 CDI86409.1 - 0.59 10.1 6.8 0.93 9.5 6.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI86409.1 - 2 7.1 5.6 2.6 6.8 5.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2722 PF10846.8 CDI86409.1 - 3.3 6.6 30.0 1.4 7.8 16.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) RBP_receptor PF14752.6 CDI86409.1 - 3.7 6.0 10.0 0.45 9.0 5.8 1.5 1 1 1 2 2 2 0 Retinol binding protein receptor EPL1 PF10513.9 CDI86409.1 - 5.7 7.3 11.8 4.5 7.6 5.6 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF2722 PF10846.8 CDI86410.1 - 0.00058 18.9 9.5 0.00058 18.9 9.5 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI86410.1 - 0.0062 16.9 3.3 0.0062 16.9 3.3 2.8 1 1 1 2 2 2 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI86410.1 - 0.0065 16.1 55.9 0.068 12.8 21.8 2.2 2 0 0 2 2 2 2 Spt20 family Suf PF05843.14 CDI86410.1 - 0.036 14.0 23.8 0.2 11.6 9.4 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Connexin PF00029.19 CDI86410.1 - 0.15 11.8 9.2 0.93 9.2 0.5 2.1 2 0 0 2 2 2 0 Connexin EPL1 PF10513.9 CDI86410.1 - 0.15 12.4 16.7 0.13 12.7 2.6 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like EOS1 PF12326.8 CDI86410.1 - 0.21 11.5 3.8 2.3 8.1 0.2 2.1 2 0 0 2 2 2 0 N-glycosylation protein DUF4820 PF16091.5 CDI86410.1 - 0.25 10.7 12.4 0.94 8.8 1.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF702 PF05142.12 CDI86410.1 - 0.29 11.6 18.6 0.16 12.5 4.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF702) TERB2 PF15101.6 CDI86410.1 - 0.34 10.9 28.1 0.82 9.7 11.0 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 ART-PolyVal PF18760.1 CDI86410.1 - 0.36 11.8 9.3 0.24 12.4 1.8 2.2 2 0 0 2 2 2 0 ADP-Ribosyltransferase in polyvalent proteins HABP4_PAI-RBP1 PF04774.15 CDI86410.1 - 0.48 11.3 21.6 0.073 13.9 5.0 2.9 3 0 0 3 3 3 0 Hyaluronan / mRNA binding family DUF4407 PF14362.6 CDI86410.1 - 0.51 9.6 29.7 0.84 8.9 12.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) OmpH PF03938.14 CDI86410.1 - 0.62 10.4 41.0 1.9 8.8 19.1 2.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) MFAP1 PF06991.11 CDI86410.1 - 0.74 9.6 21.6 0.11 12.3 5.7 2.3 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing DUF719 PF05334.13 CDI86410.1 - 1.2 9.3 17.0 2.2 8.4 6.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF719) eIF-3_zeta PF05091.12 CDI86410.1 - 1.3 7.9 25.2 0.17 10.8 5.4 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FliP PF00813.20 CDI86410.1 - 1.9 8.4 8.8 1.7 8.5 1.0 2.1 2 0 0 2 2 2 0 FliP family PRP1_N PF06424.12 CDI86410.1 - 1.9 8.8 15.9 2.1 8.7 3.7 2.2 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Nop53 PF07767.11 CDI86410.1 - 2.3 7.5 27.2 0.14 11.5 6.4 2.2 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Rxt3 PF08642.10 CDI86410.1 - 2.6 8.8 11.4 8.5 7.2 2.1 2.4 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 DUF2464 PF10240.9 CDI86410.1 - 3.1 7.3 10.1 17 4.8 4.1 2.8 3 0 0 3 3 3 0 Multivesicular body subunit 12 Dehalogenase PF13486.6 CDI86410.1 - 3.6 6.9 8.5 2.6 7.4 1.8 2.2 2 0 0 2 2 2 0 Reductive dehalogenase subunit V_ATPase_I PF01496.19 CDI86410.1 - 4.5 5.1 17.5 2.9 5.7 4.0 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family RCR PF12273.8 CDI86410.1 - 4.7 7.9 13.5 1 10.0 2.2 2.5 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red Dynamin_N PF00350.23 CDI86410.1 - 6.2 6.8 8.1 8.8 6.4 1.3 2.2 2 0 0 2 2 2 0 Dynamin family OATP PF03137.20 CDI86410.1 - 7.4 4.7 9.3 0.95 7.7 1.1 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Spore_YhcN_YlaJ PF09580.10 CDI86410.1 - 7.8 6.6 16.9 2.2 8.4 0.9 2.2 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Band_3_cyto PF07565.13 CDI86410.1 - 9 6.0 19.1 5.8 6.6 4.1 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Sec7 PF01369.20 CDI86411.1 - 0.00059 19.6 0.0 0.001 18.8 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain SUIM_assoc PF16619.5 CDI86411.1 - 0.0073 16.4 1.3 0.0073 16.4 1.3 2.2 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI86411.1 - 0.013 15.1 4.0 0.024 14.2 4.0 1.5 1 0 0 1 1 1 0 Spt20 family YajC PF02699.15 CDI86411.1 - 0.049 13.5 3.5 0.13 12.2 3.5 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit EphA2_TM PF14575.6 CDI86411.1 - 0.12 13.3 0.1 0.12 13.3 0.1 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain RskA PF10099.9 CDI86411.1 - 2.2 8.5 25.6 0.18 12.1 0.4 3.1 3 0 0 3 3 3 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI86411.1 - 3.2 7.7 10.2 1.1 9.2 6.7 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RIFIN PF02009.16 CDI86411.1 - 4.7 7.0 8.2 4.2 7.2 6.6 1.7 2 0 0 2 2 2 0 Rifin STAS PF01740.21 CDI86413.1 - 9.4e-18 64.0 0.0 1.5e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 STAS domain Sulfate_transp PF00916.20 CDI86413.1 - 0.00027 19.8 0.1 0.00043 19.2 0.1 1.3 1 0 0 1 1 1 1 Sulfate permease family STAS_2 PF13466.6 CDI86413.1 - 0.0031 17.8 0.0 0.014 15.7 0.0 2.3 1 0 0 1 1 1 1 STAS domain V_ATPase_I PF01496.19 CDI86414.1 - 0.075 11.0 9.7 0.079 10.9 9.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MKT1_C PF12246.8 CDI86414.1 - 0.11 11.7 8.0 0.053 12.7 3.9 1.9 1 1 1 2 2 2 0 Temperature dependent protein affecting M2 dsRNA replication Pan_kinase PF03309.14 CDI86414.1 - 0.48 10.2 4.6 0.33 10.7 3.4 1.4 1 1 0 1 1 1 0 Type III pantothenate kinase DUF3405 PF11885.8 CDI86414.1 - 0.5 8.9 12.1 2.6 6.5 12.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3405) Ketoacyl-synt_2 PF13723.6 CDI86414.1 - 0.65 9.6 15.9 0.84 9.2 15.9 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain Kei1 PF08552.11 CDI86414.1 - 0.91 9.4 6.0 1.1 9.1 6.0 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 SRP14 PF02290.15 CDI86414.1 - 1.5 9.2 10.4 2.1 8.7 4.7 2.1 1 1 1 2 2 2 0 Signal recognition particle 14kD protein PepSY_TM_like_2 PF16357.5 CDI86414.1 - 1.6 8.6 9.0 2 8.3 9.0 1.3 1 0 0 1 1 1 0 Putative PepSY_TM-like CSG2 PF16965.5 CDI86414.1 - 2 7.3 5.4 2.1 7.2 5.4 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 CDI86414.1 - 3.2 6.7 8.1 3.7 6.5 8.1 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4638 PF15472.6 CDI86414.1 - 3.5 7.3 12.6 4.3 7.0 12.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) PepSY_TM PF03929.16 CDI86414.1 - 4 7.0 6.9 4.9 6.7 6.9 1.2 1 0 0 1 1 1 0 PepSY-associated TM region Arv1 PF04161.13 CDI86414.1 - 4.3 7.4 7.2 5.7 7.0 7.2 1.3 1 0 0 1 1 1 0 Arv1-like family FliP PF00813.20 CDI86414.1 - 4.5 7.1 8.3 5.1 6.9 8.3 1.2 1 0 0 1 1 1 0 FliP family RR_TM4-6 PF06459.12 CDI86414.1 - 4.9 6.9 13.3 6.1 6.6 13.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI86414.1 - 5.1 5.8 13.3 6.2 5.5 13.3 1.2 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI86414.1 - 5.4 7.0 10.4 6.4 6.8 10.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region eIF-3_zeta PF05091.12 CDI86414.1 - 5.5 5.9 18.4 6.8 5.5 18.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Band_3_cyto PF07565.13 CDI86414.1 - 5.8 6.6 17.8 7.2 6.3 17.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Ctr PF04145.15 CDI86414.1 - 7.9 7.1 8.3 10 6.7 8.3 1.2 1 0 0 1 1 1 0 Ctr copper transporter family RskA PF10099.9 CDI86416.1 - 0.0014 18.9 6.0 0.0021 18.4 6.0 1.4 1 1 0 1 1 1 1 Anti-sigma-K factor rskA ORC_WH_C PF18137.1 CDI86416.1 - 0.052 13.6 8.1 4.5 7.3 0.0 2.2 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal CCSAP PF15748.5 CDI86416.1 - 0.1 12.8 13.2 0.12 12.5 13.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4407 PF14362.6 CDI86416.1 - 0.21 10.9 5.2 0.22 10.9 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) JUPITER PF17054.5 CDI86416.1 - 0.28 10.6 5.5 0.35 10.3 5.5 1.1 1 0 0 1 1 1 0 Microtubule-Associated protein Jupiter PAT1 PF09770.9 CDI86416.1 - 0.44 8.7 16.0 0.4 8.9 16.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 CDI86416.1 - 0.49 9.1 9.6 0.69 8.6 9.6 1.3 1 0 0 1 1 1 0 Presenilin RAP1 PF07218.11 CDI86416.1 - 0.61 8.3 2.1 0.69 8.1 2.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) TFIIA PF03153.13 CDI86416.1 - 0.7 9.8 34.4 0.85 9.6 34.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI86416.1 - 0.9 9.1 20.0 3.1 7.3 0.6 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein MTBP_C PF14920.6 CDI86416.1 - 1.2 8.8 17.8 1.5 8.5 17.8 1.1 1 0 0 1 1 1 0 MDM2-binding R_equi_Vir PF05526.11 CDI86416.1 - 7.8 6.3 8.8 2.7 7.8 4.7 1.9 2 0 0 2 2 2 0 Rhodococcus equi virulence-associated protein DUF572 PF04502.13 CDI86417.1 - 0.37 10.4 4.6 0.7 9.5 4.7 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF572) BCL_N PF04714.13 CDI86417.1 - 1.2 9.2 4.2 13 5.9 0.1 3.1 3 0 0 3 3 3 0 BCL7, N-terminal conserver region FAM176 PF14851.6 CDI86418.1 - 0.035 13.8 1.7 0.12 12.0 1.7 1.9 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 CDI86418.1 - 4.2 5.3 11.0 7 4.6 11.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi Sel1 PF08238.12 CDI86421.1 - 4.6e-25 87.5 16.3 0.00013 22.6 0.3 9.5 9 0 0 9 9 9 6 Sel1 repeat HSP20 PF00011.21 CDI86422.1 - 6.6e-19 68.0 0.0 9.4e-19 67.5 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDI86422.1 - 1.4e-05 24.6 0.0 2.2e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Kinesin PF00225.23 CDI86423.1 - 2.6e-29 102.2 0.0 7.1e-21 74.5 0.0 2.7 3 0 0 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 CDI86423.1 - 3e-08 33.7 0.0 6.8e-06 26.1 0.0 2.4 2 0 0 2 2 2 2 Microtubule binding TFIIA PF03153.13 CDI86423.1 - 1.3 8.9 27.5 0.43 10.5 11.8 3.5 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit zf-RING_2 PF13639.6 CDI86426.1 - 3.4e-08 33.7 3.8 3.4e-08 33.7 3.8 2.8 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDI86426.1 - 1e-07 31.7 7.1 2.2e-07 30.6 3.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI86426.1 - 2.3e-07 30.6 1.6 2.3e-07 30.6 1.6 2.8 3 0 0 3 3 3 1 zinc-RING finger domain zf-rbx1 PF12678.7 CDI86426.1 - 2.3e-06 27.8 5.1 3.2e-06 27.3 0.9 2.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 CDI86426.1 - 2.4e-06 27.3 2.8 2.4e-06 27.3 2.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDI86426.1 - 3e-06 27.0 6.9 7.8e-06 25.7 1.6 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDI86426.1 - 1.9e-05 24.6 5.6 6.6e-05 22.8 1.4 2.8 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CDI86426.1 - 2.1e-05 24.3 6.1 0.00018 21.3 1.5 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 DUF2722 PF10846.8 CDI86426.1 - 0.00015 20.8 6.2 0.00015 20.8 6.2 4.7 4 1 1 5 5 2 1 Protein of unknown function (DUF2722) zf-C3HC4_4 PF15227.6 CDI86426.1 - 0.01 16.0 2.0 0.01 16.0 2.0 2.6 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 CDI86426.1 - 0.082 13.0 0.5 0.24 11.5 0.5 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 CDI86426.1 - 0.25 11.2 3.9 0.12 12.2 1.1 1.9 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 CDI86426.1 - 0.36 10.7 6.3 0.096 12.5 1.1 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 CDI86426.1 - 2.4 8.0 5.8 3.2 7.6 0.9 3.0 3 0 0 3 3 3 0 RING-like zinc finger zf-RING_10 PF16685.5 CDI86426.1 - 7.7 6.7 7.4 0.77 9.9 2.1 1.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 MatC_N PF07158.11 CDI86427.1 - 0.00045 20.3 0.2 1.2 9.2 0.0 2.1 2 0 0 2 2 2 2 Dicarboxylate carrier protein MatC N-terminus ANAPC_CDC26 PF10471.9 CDI86427.1 - 0.0073 17.1 6.8 0.0073 17.1 6.8 4.6 3 2 1 4 4 4 1 Anaphase-promoting complex APC subunit CDC26 DUF2207 PF09972.9 CDI86427.1 - 0.037 12.8 0.4 2.4 6.8 0.2 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) T2SSF PF00482.23 CDI86427.1 - 0.092 12.7 0.1 0.092 12.7 0.1 3.6 4 0 0 4 4 4 0 Type II secretion system (T2SS), protein F SART-1 PF03343.13 CDI86427.1 - 3.5 6.1 34.8 4.2 5.8 34.8 1.0 1 0 0 1 1 1 0 SART-1 family TMEM223 PF14640.6 CDI86427.1 - 3.7 7.7 9.5 1.8 8.7 0.3 2.9 2 1 1 3 3 3 0 Transmembrane protein 223 NAGPA PF09992.9 CDI86427.1 - 5.7 7.1 10.5 6.4 6.9 2.0 2.6 1 1 1 2 2 2 0 Phosphodiester glycosidase DUF2722 PF10846.8 CDI86428.1 - 0.00011 21.4 11.7 0.00011 21.4 11.7 4.6 4 2 0 4 4 2 1 Protein of unknown function (DUF2722) SseC PF04888.12 CDI86428.1 - 0.00063 19.4 28.1 0.00063 19.4 28.1 5.2 6 0 0 6 6 3 1 Secretion system effector C (SseC) like family Pex14_N PF04695.13 CDI86428.1 - 0.0099 16.5 10.6 0.0099 16.5 10.6 4.8 2 1 1 3 3 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region SpoIIP PF07454.11 CDI86428.1 - 0.024 14.1 31.4 0.13 11.7 10.9 3.3 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) Gate PF07670.14 CDI86428.1 - 0.17 12.1 1.0 0.45 10.8 0.2 2.1 2 0 0 2 2 2 0 Nucleoside recognition Nha1_C PF08619.10 CDI86428.1 - 0.25 10.5 39.9 1.5 8.0 7.5 3.2 3 0 0 3 3 3 0 Alkali metal cation/H+ antiporter Nha1 C terminus PAT1 PF09770.9 CDI86428.1 - 0.59 8.3 61.4 0.086 11.1 10.5 3.0 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 FAM60A PF15396.6 CDI86428.1 - 0.72 9.8 28.2 2.1 8.3 0.8 3.3 3 0 0 3 3 3 0 Protein Family FAM60A DUF2407_C PF13373.6 CDI86428.1 - 0.83 9.8 16.1 1.1 9.5 0.2 3.4 3 0 0 3 3 3 0 DUF2407 C-terminal domain CDC45 PF02724.14 CDI86428.1 - 0.96 7.7 23.7 0.33 9.2 1.8 3.0 3 0 0 3 3 3 0 CDC45-like protein Presenilin PF01080.17 CDI86428.1 - 1.1 7.9 49.0 1.4 7.6 18.2 3.2 3 0 0 3 3 3 0 Presenilin FAM76 PF16046.5 CDI86428.1 - 1.2 8.5 29.2 0.42 9.9 8.3 3.3 3 0 0 3 3 3 0 FAM76 protein DUF4471 PF14740.6 CDI86428.1 - 1.8 7.7 16.5 0.49 9.6 3.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4471) LTV PF04180.14 CDI86428.1 - 2.7 7.6 25.9 0.34 10.6 6.3 3.1 3 0 0 3 3 3 0 Low temperature viability protein FSA_C PF10479.9 CDI86429.1 - 1.5 6.9 16.9 2 6.5 16.9 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF2722 PF10846.8 CDI86429.1 - 2.3 7.1 13.4 0.011 14.7 1.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF2722 PF10846.8 CDI86430.1 - 2.7e-05 23.3 2.9 2.7e-05 23.3 2.9 17.3 11 4 2 16 16 16 6 Protein of unknown function (DUF2722) N6_N4_Mtase PF01555.18 CDI86430.1 - 2.1 8.0 5.6 46 3.6 1.1 4.8 6 1 0 6 6 6 0 DNA methylase Macoilin PF09726.9 CDI86431.1 - 5.5e-05 22.0 32.2 8.3e-05 21.4 32.2 1.2 1 0 0 1 1 1 1 Macoilin family PI3K_1B_p101 PF10486.9 CDI86431.1 - 9.1e-05 20.5 10.1 9.1e-05 20.5 10.1 1.1 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TFIIA PF03153.13 CDI86431.1 - 0.017 15.1 51.6 0.023 14.7 51.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MMR1 PF08505.10 CDI86431.1 - 0.048 13.9 33.0 0.059 13.7 33.0 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Pinin_SDK_memA PF04696.13 CDI86431.1 - 0.087 12.9 26.0 0.16 12.0 26.0 1.4 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region DUF2052 PF09747.9 CDI86431.1 - 0.16 12.1 17.9 0.24 11.5 17.9 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Lin-8 PF03353.15 CDI86431.1 - 0.21 11.1 28.9 0.31 10.5 28.9 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Plasmodium_Vir PF05795.11 CDI86431.1 - 0.22 10.9 15.6 0.23 10.8 15.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF1387 PF07139.11 CDI86431.1 - 0.35 10.6 23.4 0.47 10.1 23.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) GREB1 PF15782.5 CDI86431.1 - 0.71 6.9 29.9 0.77 6.8 29.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Exonuc_VII_L PF02601.15 CDI86431.1 - 1 8.9 26.0 1.8 8.1 26.0 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit CDK5_activator PF03261.15 CDI86431.1 - 1.3 8.5 24.2 1.6 8.2 24.2 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Apt1 PF10351.9 CDI86431.1 - 2.3 7.0 27.4 3.5 6.4 27.4 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain PAT1 PF09770.9 CDI86431.1 - 4.8 5.3 36.6 5.3 5.2 36.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 CDI86431.1 - 7.6 5.4 29.0 9.7 5.1 29.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PBP_sp32 PF07222.12 CDI86431.1 - 9 5.7 24.8 0.026 14.0 14.5 1.9 2 0 0 2 2 2 0 Proacrosin binding protein sp32 Dapper PF15268.6 CDI86432.1 - 0.037 12.9 62.9 0.044 12.6 62.9 1.1 1 0 0 1 1 1 0 Dapper Asp-B-Hydro_N PF05279.11 CDI86432.1 - 0.23 11.5 46.2 0.31 11.1 46.2 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region LAP1C PF05609.12 CDI86432.1 - 3.6 6.6 64.1 5 6.1 64.1 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RskA PF10099.9 CDI86435.1 - 3.4e-11 43.8 22.0 6e-05 23.4 4.5 3.3 1 1 2 3 3 3 3 Anti-sigma-K factor rskA Pex14_N PF04695.13 CDI86435.1 - 0.023 15.3 11.8 0.023 15.3 11.8 4.1 2 2 1 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Protamine_P2 PF00841.19 CDI86435.1 - 0.027 15.0 10.4 0.027 15.0 10.4 4.7 4 1 1 5 5 5 0 Sperm histone P2 NUC153 PF08159.12 CDI86435.1 - 0.12 12.2 0.2 0.12 12.2 0.2 2.1 2 0 0 2 2 2 0 NUC153 domain SR-25 PF10500.9 CDI86435.1 - 0.67 9.5 69.9 0.13 11.8 16.0 3.2 1 1 2 3 3 3 0 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI86436.1 - 0.019 13.9 15.5 0.019 13.9 15.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) NST1 PF13945.6 CDI86436.1 - 0.03 14.4 9.4 0.035 14.2 9.4 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF3439 PF11921.8 CDI86436.1 - 0.072 13.1 0.2 0.085 12.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TFIIA PF03153.13 CDI86436.1 - 0.096 12.7 27.4 0.11 12.5 27.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Mcm10 PF09332.11 CDI86436.1 - 0.33 10.3 11.3 0.34 10.3 11.3 1.2 1 0 0 1 1 1 0 Mcm10 replication factor SOG2 PF10428.9 CDI86436.1 - 0.38 9.9 12.8 0.44 9.7 12.8 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein FAM76 PF16046.5 CDI86436.1 - 0.49 9.7 9.7 0.52 9.6 9.7 1.0 1 0 0 1 1 1 0 FAM76 protein PCNP PF15473.6 CDI86436.1 - 0.82 10.4 8.6 1.3 9.7 8.6 1.3 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family Mucin PF01456.17 CDI86436.1 - 0.84 9.6 17.6 1.1 9.3 17.6 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Menin PF05053.13 CDI86436.1 - 1.2 7.5 11.1 1.3 7.3 11.1 1.1 1 0 0 1 1 1 0 Menin FSA_C PF10479.9 CDI86436.1 - 1.8 6.6 8.1 2 6.4 8.1 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus MMR1 PF08505.10 CDI86436.1 - 1.8 8.8 11.6 1.7 8.9 11.6 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Peptidase_S15 PF02129.18 CDI86436.1 - 1.9 8.0 12.3 2.3 7.7 12.3 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) SKA1 PF07160.12 CDI86436.1 - 2 8.2 12.7 2.2 8.1 12.7 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Hist_deacetyl PF00850.19 CDI86436.1 - 2.6 7.4 5.7 3.1 7.2 5.7 1.2 1 0 0 1 1 1 0 Histone deacetylase domain RIFIN PF02009.16 CDI86436.1 - 2.9 7.7 15.0 3.6 7.4 15.0 1.3 1 0 0 1 1 1 0 Rifin BAF1_ABF1 PF04684.13 CDI86436.1 - 3 6.8 17.1 3.4 6.6 17.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor WDCP PF15390.6 CDI86436.1 - 3.1 6.0 9.0 3.4 5.9 9.0 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family DUF4718 PF15842.5 CDI86436.1 - 3.3 7.5 7.8 4.6 7.0 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) Spc24 PF08286.11 CDI86436.1 - 3.4 8.0 15.7 2.6 8.3 1.6 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 CLN3 PF02487.17 CDI86436.1 - 4.8 6.1 7.6 5.4 5.9 7.6 1.2 1 0 0 1 1 1 0 CLN3 protein Hamartin PF04388.12 CDI86436.1 - 4.9 5.7 12.7 5.2 5.6 12.7 1.0 1 0 0 1 1 1 0 Hamartin protein Hid1 PF12722.7 CDI86436.1 - 5.1 5.1 12.5 5.8 4.9 12.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CDI86436.1 - 5.2 4.1 9.3 4.7 4.2 9.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer XRN_M PF17846.1 CDI86436.1 - 5.2 5.9 10.8 5.1 5.9 10.8 1.2 1 0 0 1 1 1 0 Xrn1 helical domain UPF0565 PF10561.9 CDI86436.1 - 6.2 5.9 7.3 8 5.6 7.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Ndc1_Nup PF09531.10 CDI86436.1 - 6.5 5.3 14.9 7.5 5.1 14.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MPM1 PF17234.2 CDI86436.1 - 7.1 6.9 12.1 0.51 10.6 7.6 1.5 2 0 0 2 2 1 0 Mitochondrial peculiar membrane protein 1 Gti1_Pac2 PF09729.9 CDI86436.1 - 7.9 6.5 9.9 11 6.1 9.9 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Neur_chan_memb PF02932.16 CDI86436.1 - 8 6.4 10.4 9.7 6.2 10.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SAP130_C PF16014.5 CDI86436.1 - 8.4 5.4 13.9 9.5 5.2 13.9 1.1 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus Peptidase_S64 PF08192.11 CDI86436.1 - 8.9 4.7 9.3 8.7 4.7 9.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 SLC12 PF03522.15 CDI86436.1 - 9.1 5.2 13.6 11 5.0 13.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Sin_N PF04801.13 CDI86436.1 - 10 5.2 23.3 11 5.1 23.3 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region IMUP PF15761.5 CDI86437.1 - 0.0035 18.0 14.2 0.0046 17.6 14.2 1.3 1 0 0 1 1 1 1 Immortalisation up-regulated protein SR-25 PF10500.9 CDI86437.1 - 0.17 11.5 25.9 0.27 10.8 25.9 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.15 CDI86437.1 - 0.2 12.5 22.2 0.49 11.3 22.2 1.6 1 1 0 1 1 1 0 Chorion family 2 SCP1201-deam PF14428.6 CDI86437.1 - 0.37 10.7 9.4 0.49 10.3 9.4 1.1 1 0 0 1 1 1 0 SCP1.201-like deaminase FAM199X PF15814.5 CDI86437.1 - 1.5 7.8 20.4 1.5 7.8 20.4 1.0 1 0 0 1 1 1 0 Protein family FAM199X DUF755 PF05501.11 CDI86437.1 - 7.6 6.8 37.4 1.5 9.2 25.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF755) DUF2722 PF10846.8 CDI86438.1 - 0.00021 20.4 19.6 0.00021 20.4 19.6 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Lin-8 PF03353.15 CDI86438.1 - 0.00049 19.8 5.1 0.00049 19.8 5.1 2.2 2 0 0 2 2 2 1 Ras-mediated vulval-induction antagonist PRP3 PF08572.10 CDI86438.1 - 0.00084 19.1 2.4 0.0016 18.3 2.4 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) Peroxin-3 PF04882.12 CDI86438.1 - 0.0054 15.8 6.9 0.0054 15.8 6.9 2.1 2 0 0 2 2 2 1 Peroxin-3 RskA PF10099.9 CDI86438.1 - 0.012 15.9 22.7 0.054 13.8 23.5 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI86438.1 - 0.014 14.4 8.3 0.018 14.0 8.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GNAT_acetyltr_2 PF13718.6 CDI86438.1 - 0.028 13.8 0.1 0.028 13.8 0.1 1.9 2 0 0 2 2 2 0 GNAT acetyltransferase 2 RED_N PF07808.13 CDI86438.1 - 0.032 13.8 13.5 0.013 15.1 11.0 1.6 1 1 0 1 1 1 0 RED-like protein N-terminal region DUF4834 PF16118.5 CDI86438.1 - 0.049 14.6 21.3 0.15 13.1 6.8 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) PAT1 PF09770.9 CDI86438.1 - 0.33 9.2 15.0 0.39 8.9 15.0 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CNDH2_M PF16869.5 CDI86438.1 - 0.43 11.3 24.0 1.1 10.0 4.9 3.3 3 0 0 3 3 3 0 PF16858 Fmp27_WPPW PF10359.9 CDI86438.1 - 0.47 9.2 21.4 0.041 12.8 5.2 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain FAM176 PF14851.6 CDI86438.1 - 0.59 9.8 15.9 0.031 13.9 3.3 2.9 2 1 1 3 3 3 0 FAM176 family Nucleoside_tran PF01733.18 CDI86438.1 - 0.83 9.0 3.3 0.2 11.0 0.1 1.6 2 0 0 2 2 2 0 Nucleoside transporter Plasmodium_Vir PF05795.11 CDI86438.1 - 0.95 8.8 17.7 0.04 13.3 1.5 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Comm PF15957.5 CDI86438.1 - 2.9 8.3 7.8 0.13 12.7 1.6 1.9 2 0 0 2 2 1 0 Commissureless Secretin_N_2 PF07655.13 CDI86438.1 - 3.2 8.4 57.3 9.3 6.9 0.4 3.3 3 0 0 3 3 3 0 Secretin N-terminal domain CPSF100_C PF13299.6 CDI86438.1 - 4.9 7.3 21.6 0.22 11.7 6.5 2.8 1 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal EphA2_TM PF14575.6 CDI86438.1 - 5.1 8.1 7.3 3 8.8 2.7 2.7 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain SAPS PF04499.15 CDI86438.1 - 5.2 5.7 15.3 2.9e+02 -0.0 15.3 2.1 1 1 0 1 1 1 0 SIT4 phosphatase-associated protein cwf18 PF08315.12 CDI86438.1 - 5.7 7.6 13.0 1.3 9.6 1.5 2.6 3 0 0 3 3 3 0 cwf18 pre-mRNA splicing factor ALMT PF11744.8 CDI86438.1 - 8.9 5.0 16.1 0.51 9.1 2.5 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter Auxin_canalis PF05703.11 CDI86439.1 - 1.5 8.7 11.9 0.061 13.2 4.9 1.8 2 0 0 2 2 2 0 Auxin canalisation ATG22 PF11700.8 CDI86439.1 - 2.2 6.8 4.7 0.38 9.3 0.2 1.7 2 0 0 2 2 2 0 Vacuole effluxer Atg22 like Neur_chan_memb PF02932.16 CDI86439.1 - 2.7 8.0 10.3 0.46 10.5 2.3 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Cyt_bd_oxida_II PF02322.15 CDI86440.1 - 3.4 7.0 22.7 0.08 12.3 12.2 2.1 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II DUF4175 PF13779.6 CDI86441.1 - 0.0014 16.6 69.1 0.0017 16.4 69.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) Pterin_bind PF00809.22 CDI86441.1 - 0.02 14.5 1.1 0.02 14.5 1.1 2.0 1 1 1 2 2 2 0 Pterin binding enzyme DUF1786 PF08735.10 CDI86441.1 - 0.029 13.7 2.2 0.035 13.4 1.8 1.3 1 1 0 1 1 1 0 Putative pyruvate format-lyase activating enzyme (DUF1786) BAF1_ABF1 PF04684.13 CDI86441.1 - 0.048 12.7 26.2 0.056 12.5 26.2 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4407 PF14362.6 CDI86441.1 - 0.069 12.5 47.2 0.08 12.3 47.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 CDI86441.1 - 0.22 9.4 28.6 0.27 9.1 28.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mitofilin PF09731.9 CDI86441.1 - 0.25 10.1 33.5 0.31 9.8 33.5 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein ATG16 PF08614.11 CDI86441.1 - 0.28 11.4 45.0 0.42 10.8 45.0 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) WES_acyltransf PF03007.16 CDI86441.1 - 0.61 9.8 14.7 0.8 9.4 14.7 1.3 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain E2F_TDP PF02319.20 CDI86441.1 - 0.98 9.5 3.4 2 8.5 2.9 2.0 1 1 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain DUF5427 PF10310.9 CDI86441.1 - 1.7 7.5 34.6 2.2 7.1 34.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Ndc1_Nup PF09531.10 CDI86441.1 - 1.7 7.2 31.0 2 7.0 31.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Spc7 PF08317.11 CDI86441.1 - 2.7 6.8 40.8 3.7 6.3 40.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FUSC PF04632.12 CDI86441.1 - 4.1 5.8 28.4 5.1 5.5 28.4 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF2828 PF11443.8 CDI86442.1 - 0.00027 19.2 17.1 0.0003 19.0 17.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) NARP1 PF12569.8 CDI86442.1 - 0.002 17.1 16.2 0.0022 17.0 16.2 1.0 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 CobT PF06213.12 CDI86442.1 - 0.017 14.5 27.6 0.02 14.3 27.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PIP5K PF01504.18 CDI86442.1 - 0.023 13.9 13.9 0.024 13.9 13.9 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Velvet PF11754.8 CDI86442.1 - 0.05 13.5 20.7 0.054 13.4 20.7 1.1 1 0 0 1 1 1 0 Velvet factor TCP PF03634.13 CDI86442.1 - 0.051 14.1 18.6 0.061 13.9 18.6 1.3 1 0 0 1 1 1 0 TCP family transcription factor Connexin PF00029.19 CDI86442.1 - 0.055 13.2 20.7 0.074 12.8 20.7 1.2 1 0 0 1 1 1 0 Connexin DUF5308 PF17233.2 CDI86442.1 - 0.071 13.3 14.8 0.099 12.9 14.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF913 PF06025.12 CDI86442.1 - 0.076 12.0 11.5 0.082 11.9 11.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 CDI86442.1 - 0.094 12.5 21.8 0.1 12.4 21.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3295 PF11702.8 CDI86442.1 - 0.13 11.5 19.7 0.15 11.4 19.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DUF4045 PF13254.6 CDI86442.1 - 0.17 11.5 17.5 0.18 11.4 17.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DDHD PF02862.17 CDI86442.1 - 0.2 11.8 20.0 0.24 11.5 20.0 1.2 1 0 0 1 1 1 0 DDHD domain DUF1764 PF08576.10 CDI86442.1 - 0.27 12.1 18.9 0.42 11.5 18.9 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) TFIIA PF03153.13 CDI86442.1 - 0.29 11.1 62.8 0.44 10.5 62.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CCSAP PF15748.5 CDI86442.1 - 0.3 11.2 25.9 0.33 11.1 25.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF3314 PF11771.8 CDI86442.1 - 0.43 10.7 14.0 0.38 10.9 6.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3314) SLC12 PF03522.15 CDI86442.1 - 0.47 9.4 25.6 0.57 9.1 25.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Band_3_cyto PF07565.13 CDI86442.1 - 0.53 10.0 21.6 0.63 9.8 21.6 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain eIF-3_zeta PF05091.12 CDI86442.1 - 0.54 9.2 30.4 0.58 9.1 30.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Baculo_PP31 PF05311.11 CDI86442.1 - 0.61 9.5 18.0 0.72 9.3 18.0 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) SpoIIP PF07454.11 CDI86442.1 - 0.61 9.5 26.0 0.73 9.2 26.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) GNAT_acetyltr_2 PF13718.6 CDI86442.1 - 0.67 9.3 14.5 0.86 9.0 14.5 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 FAM60A PF15396.6 CDI86442.1 - 0.69 9.9 20.2 0.83 9.6 20.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CPSF100_C PF13299.6 CDI86442.1 - 0.71 10.0 18.7 0.97 9.6 18.7 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Sin_N PF04801.13 CDI86442.1 - 0.78 8.9 36.8 0.97 8.6 36.8 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region Topoisom_I_N PF02919.15 CDI86442.1 - 0.93 9.0 22.1 56 3.1 22.1 2.0 1 1 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Ribonuc_P_40 PF08584.11 CDI86442.1 - 0.96 8.7 17.2 1.1 8.4 17.2 1.1 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit Lin-8 PF03353.15 CDI86442.1 - 1.1 8.7 31.1 1.4 8.4 31.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2370 PF10176.9 CDI86442.1 - 1.3 8.7 12.7 1.5 8.4 12.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Presenilin PF01080.17 CDI86442.1 - 1.4 7.6 30.7 1.6 7.4 30.7 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 CDI86442.1 - 1.6 6.9 21.4 1.9 6.7 21.4 1.0 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 CDI86442.1 - 1.7 7.4 21.0 1.9 7.2 21.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 GPCR_chapero_1 PF11904.8 CDI86442.1 - 1.7 8.0 14.9 1.9 7.8 14.9 1.1 1 0 0 1 1 1 0 GPCR-chaperone DUF3408 PF11888.8 CDI86442.1 - 1.7 8.7 24.3 2.6 8.2 24.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) SID-1_RNA_chan PF13965.6 CDI86442.1 - 1.9 6.8 14.4 2.1 6.7 14.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 BORG_CEP PF14957.6 CDI86442.1 - 1.9 9.6 15.7 2.7 9.2 15.7 1.3 1 0 0 1 1 1 0 Cdc42 effector F-protein PF00469.20 CDI86442.1 - 2.6 7.6 24.8 3.2 7.3 24.8 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef DUF4746 PF15928.5 CDI86442.1 - 2.8 7.3 17.7 3.3 7.0 17.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF853 PF05872.12 CDI86442.1 - 2.9 6.4 17.5 3.6 6.1 17.5 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) CCDC53 PF10152.9 CDI86442.1 - 3 8.3 26.7 4.1 7.8 26.7 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Peptidase_S15 PF02129.18 CDI86442.1 - 3 7.4 18.2 3.7 7.1 18.2 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF4228 PF14009.6 CDI86442.1 - 3.2 8.1 11.4 4.8 7.6 11.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Serinc PF03348.15 CDI86442.1 - 3.6 6.4 14.7 4.1 6.2 14.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Peptidase_S49_N PF08496.10 CDI86442.1 - 3.6 7.6 26.2 5.1 7.1 26.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MDM10 PF12519.8 CDI86442.1 - 4 6.2 22.5 4.4 6.0 22.5 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 GREB1 PF15782.5 CDI86442.1 - 4.1 4.4 26.1 4.4 4.3 26.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 CDI86442.1 - 4.4 7.3 21.5 5.1 7.1 21.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Kei1 PF08552.11 CDI86442.1 - 5.1 6.9 16.6 6.5 6.6 16.6 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 SART-1 PF03343.13 CDI86442.1 - 5.9 5.3 29.2 7.2 5.0 29.2 1.0 1 0 0 1 1 1 0 SART-1 family G-patch_2 PF12656.7 CDI86442.1 - 6 7.0 13.3 5.1e+02 0.9 13.3 2.9 1 1 0 1 1 1 0 G-patch domain Hamartin PF04388.12 CDI86442.1 - 6.4 5.3 24.3 6.8 5.2 24.3 1.0 1 0 0 1 1 1 0 Hamartin protein VIR_N PF15912.5 CDI86442.1 - 6.6 6.3 14.4 8.2 5.9 14.4 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal FAM176 PF14851.6 CDI86442.1 - 6.8 6.3 15.1 10 5.8 15.1 1.4 1 0 0 1 1 1 0 FAM176 family Tim54 PF11711.8 CDI86442.1 - 6.9 5.3 22.3 8.5 5.0 22.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 HCO3_cotransp PF00955.21 CDI86442.1 - 8.2 5.1 13.3 9.3 4.9 13.3 1.0 1 0 0 1 1 1 0 HCO3- transporter family AUX_IAA PF02309.16 CDI86442.1 - 8.9 6.1 17.4 11 5.8 17.4 1.1 1 0 0 1 1 1 0 AUX/IAA family DUF1387 PF07139.11 CDI86442.1 - 9.2 5.9 25.7 12 5.6 25.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Plasmodium_Vir PF05795.11 CDI86442.1 - 9.3 5.6 13.4 9.5 5.5 13.4 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CSG2 PF16965.5 CDI86442.1 - 9.4 5.1 14.8 11 4.8 14.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator HNOBA PF07701.14 CDI86442.1 - 9.5 5.6 21.6 13 5.1 21.6 1.2 1 0 0 1 1 1 0 Heme NO binding associated Paf1 PF03985.13 CDI86442.1 - 10 5.0 29.7 12 4.8 29.7 1.2 1 0 0 1 1 1 0 Paf1 MMR1 PF08505.10 CDI86443.1 - 0.0034 17.7 9.1 0.0034 17.7 9.1 2.5 2 1 0 2 2 2 1 Mitochondrial Myo2 receptor-related protein DUF2052 PF09747.9 CDI86443.1 - 0.45 10.6 41.6 0.042 14.0 6.1 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SLC12 PF03522.15 CDI86443.1 - 0.56 9.2 40.4 0.072 12.1 6.2 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Presenilin PF01080.17 CDI86443.1 - 4.3 6.0 54.2 0.025 13.4 8.6 2.2 2 0 0 2 2 2 0 Presenilin Hamartin PF04388.12 CDI86443.1 - 4.5 5.8 36.5 1.1 7.8 19.4 2.1 2 0 0 2 2 2 0 Hamartin protein CDC45 PF02724.14 CDI86443.1 - 8.8 4.5 37.2 3.6 5.8 8.7 2.1 2 0 0 2 2 2 0 CDC45-like protein IHABP4_N PF16174.5 CDI86444.1 - 0.00019 22.0 19.4 0.00067 20.3 9.6 2.2 2 0 0 2 2 2 2 Intracellular hyaluronan-binding protein 4 N-terminal RskA PF10099.9 CDI86444.1 - 0.0041 17.4 27.4 0.024 14.9 3.8 2.9 2 1 0 2 2 2 2 Anti-sigma-K factor rskA RXT2_N PF08595.11 CDI86444.1 - 0.11 12.5 8.0 4.6 7.3 5.0 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal Ribosomal_60s PF00428.19 CDI86444.1 - 0.62 10.7 14.1 1.6 9.3 14.1 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein PNISR PF15996.5 CDI86444.1 - 0.75 10.0 20.9 0.089 13.1 6.1 2.4 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR eIF-3_zeta PF05091.12 CDI86444.1 - 0.82 8.6 21.9 1 8.2 9.6 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Phostensin_N PF13916.6 CDI86444.1 - 1.3 9.4 25.3 0.44 10.9 3.3 3.7 3 0 0 3 3 3 0 PP1-regulatory protein, Phostensin N-terminal RNA_pol_Rpb8 PF03870.15 CDI86444.1 - 6.5 6.9 9.7 1.1 9.5 2.8 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb8 FAM76 PF16046.5 CDI86445.1 - 0.0012 18.3 6.0 0.0012 18.3 6.0 1.1 1 0 0 1 1 1 1 FAM76 protein Sec62 PF03839.16 CDI86445.1 - 0.0015 18.1 2.2 0.0015 18.1 2.2 1.1 1 0 0 1 1 1 1 Translocation protein Sec62 EPL1 PF10513.9 CDI86445.1 - 0.002 18.6 8.5 0.002 18.6 8.5 1.2 1 0 0 1 1 1 1 Enhancer of polycomb-like LCD1 PF09798.9 CDI86445.1 - 0.0072 14.9 4.1 0.0077 14.8 4.1 1.1 1 0 0 1 1 1 1 DNA damage checkpoint protein Glyco_transf_15 PF01793.16 CDI86445.1 - 0.01 15.2 1.4 0.011 15.1 1.4 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase CobT PF06213.12 CDI86445.1 - 0.018 14.4 10.9 0.021 14.3 10.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SpoIIP PF07454.11 CDI86445.1 - 0.022 14.2 7.1 0.02 14.3 7.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Zip PF02535.22 CDI86445.1 - 0.023 13.9 5.1 0.021 14.0 5.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SLC12 PF03522.15 CDI86445.1 - 0.025 13.6 6.6 0.024 13.7 6.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Peptidase_S64 PF08192.11 CDI86445.1 - 0.051 12.1 5.0 0.051 12.1 5.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 TFIIA PF03153.13 CDI86445.1 - 0.084 12.9 35.3 0.14 12.1 35.3 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM60A PF15396.6 CDI86445.1 - 0.095 12.7 3.8 0.094 12.7 3.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Bul1_N PF04425.12 CDI86445.1 - 0.12 11.1 7.0 0.12 11.1 7.0 1.1 1 0 0 1 1 1 0 Bul1 N terminus DUF1387 PF07139.11 CDI86445.1 - 0.14 11.8 10.4 0.15 11.8 10.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) EMC3_TMCO1 PF01956.16 CDI86445.1 - 0.14 11.9 2.7 0.12 12.1 2.7 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Lin-8 PF03353.15 CDI86445.1 - 0.21 11.1 17.8 0.23 11.0 17.8 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MDM10 PF12519.8 CDI86445.1 - 0.22 10.4 6.6 0.23 10.3 6.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Otopetrin PF03189.13 CDI86445.1 - 0.25 10.1 3.5 0.25 10.1 3.5 1.1 1 0 0 1 1 1 0 Otopetrin PEHE PF15275.6 CDI86445.1 - 0.26 11.9 13.0 0.31 11.7 13.0 1.2 1 0 0 1 1 1 0 PEHE domain FUSC PF04632.12 CDI86445.1 - 0.41 9.1 8.0 0.5 8.8 8.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family OATP PF03137.20 CDI86445.1 - 0.45 8.7 3.0 0.47 8.7 3.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SPX PF03105.19 CDI86445.1 - 0.82 9.5 14.1 0.91 9.4 14.1 1.1 1 0 0 1 1 1 0 SPX domain Neur_chan_memb PF02932.16 CDI86445.1 - 1.6 8.8 11.5 1.7 8.6 11.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PAT1 PF09770.9 CDI86445.1 - 1.8 6.8 29.7 1.9 6.6 29.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BBS2_C PF14782.6 CDI86445.1 - 2 7.1 14.8 2.4 6.8 14.8 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal Hid1 PF12722.7 CDI86445.1 - 2.1 6.4 10.4 2.1 6.4 10.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CDI86445.1 - 2.3 5.2 11.9 2.3 5.2 11.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 CDI86445.1 - 2.5 6.8 17.4 2.9 6.5 17.4 1.1 1 0 0 1 1 1 0 Presenilin CPSF100_C PF13299.6 CDI86445.1 - 4.9 7.3 10.7 7.1 6.8 10.7 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Tim54 PF11711.8 CDI86445.1 - 5.4 5.7 14.0 5.9 5.6 14.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ctr PF04145.15 CDI86445.1 - 6.2 7.4 7.1 7.4 7.2 7.1 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Plasmodium_Vir PF05795.11 CDI86445.1 - 6.7 6.0 6.6 6.5 6.1 6.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein AUX_IAA PF02309.16 CDI86445.1 - 6.9 6.5 8.3 7.7 6.3 8.3 1.2 1 0 0 1 1 1 0 AUX/IAA family Sporozoite_P67 PF05642.11 CDI86446.1 - 0.23 9.5 8.8 0.29 9.2 8.8 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SR-25 PF10500.9 CDI86446.1 - 1.9 8.1 25.6 0.11 12.1 17.6 2.4 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Cyt_bd_oxida_II PF02322.15 CDI86446.1 - 3.5 6.9 15.3 2.5 7.4 8.2 2.1 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II DUF4064 PF13273.6 CDI86446.1 - 5.3 7.4 8.8 7.8 6.8 0.1 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF4064) SKIP_SNW PF02731.15 CDI86447.1 - 0.0034 17.1 2.5 0.005 16.5 2.5 1.2 1 0 0 1 1 1 1 SKIP/SNW domain TIP41 PF04176.13 CDI86447.1 - 0.016 14.7 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 TIP41-like family DUF2722 PF10846.8 CDI86447.1 - 0.16 10.9 6.4 0.21 10.5 6.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI86447.1 - 0.24 12.0 9.4 0.33 11.6 9.4 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 CDI86447.1 - 0.27 11.2 12.5 0.27 11.2 12.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ins145_P3_rec PF08709.11 CDI86449.1 - 0.012 14.8 0.0 1.3 8.2 0.0 2.3 2 0 0 2 2 2 0 Inositol 1,4,5-trisphosphate/ryanodine receptor AAA_2 PF07724.14 CDI86450.1 - 2.6e-27 96.0 0.1 4.1e-27 95.4 0.1 1.3 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.9 CDI86450.1 - 3.4e-14 52.6 0.0 5.8e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CDI86450.1 - 6.4e-05 23.0 0.0 0.00025 21.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Nitroreductase PF00881.24 CDI86452.1 - 0.28 11.2 6.1 0.38 10.8 6.1 1.3 1 0 0 1 1 1 0 Nitroreductase family AIF_C PF14721.6 CDI86453.1 - 0.14 12.5 16.2 0.16 12.3 16.2 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Pex14_N PF04695.13 CDI86453.1 - 0.74 10.5 31.6 0.81 10.3 31.6 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4746 PF15928.5 CDI86453.1 - 1.3 8.4 17.9 1.4 8.3 17.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4770 PF15994.5 CDI86453.1 - 1.6 8.9 19.5 1.9 8.7 19.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF702 PF05142.12 CDI86453.1 - 2.2 8.8 18.7 2.7 8.5 18.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) EIIBC-GUT_N PF03612.14 CDI86453.1 - 2.5 7.8 17.9 3 7.6 17.9 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus eIF3_subunit PF08597.10 CDI86453.1 - 2.5 8.0 27.9 2.7 7.8 27.9 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit TFB6 PF17110.5 CDI86453.1 - 2.6 7.7 12.5 2.9 7.6 12.5 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF3408 PF11888.8 CDI86453.1 - 2.9 8.0 22.1 3.6 7.7 22.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) CobT PF06213.12 CDI86453.1 - 2.9 7.2 28.7 3.1 7.1 28.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Peptidase_U57 PF05582.12 CDI86453.1 - 3 7.0 14.7 3 7.0 14.7 1.1 1 0 0 1 1 1 0 YabG peptidase U57 SpoIIP PF07454.11 CDI86453.1 - 3.2 7.1 23.2 3.3 7.1 23.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) eIF-3_zeta PF05091.12 CDI86453.1 - 3.7 6.4 29.4 4.1 6.3 29.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Velvet PF11754.8 CDI86453.1 - 4.3 7.2 21.2 4.5 7.1 21.2 1.0 1 0 0 1 1 1 0 Velvet factor DUF3043 PF11241.8 CDI86453.1 - 4.5 7.3 16.3 6 6.9 16.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) MMU163 PF17119.5 CDI86453.1 - 5 6.2 13.7 5.4 6.1 13.7 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Connexin PF00029.19 CDI86453.1 - 5.3 6.7 17.0 5.3 6.7 17.0 1.1 1 0 0 1 1 1 0 Connexin PAT1 PF09770.9 CDI86453.1 - 5.7 5.1 33.5 5.6 5.1 33.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Endostatin PF06482.11 CDI86453.1 - 6 6.2 19.4 6.5 6.1 19.4 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin TERB2 PF15101.6 CDI86453.1 - 7.5 6.5 27.3 8.4 6.4 27.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TFIIA PF03153.13 CDI86453.1 - 7.7 6.4 47.2 8.5 6.2 47.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CPSF100_C PF13299.6 CDI86453.1 - 8.8 6.5 18.8 10 6.3 18.8 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DDHD PF02862.17 CDI86453.1 - 8.9 6.4 20.4 9.2 6.3 20.4 1.1 1 0 0 1 1 1 0 DDHD domain EOS1 PF12326.8 CDI86453.1 - 9.5 6.1 12.7 10 6.0 12.7 1.2 1 0 0 1 1 1 0 N-glycosylation protein Band_3_cyto PF07565.13 CDI86453.1 - 9.5 5.9 22.0 9.9 5.9 22.0 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Kei1 PF08552.11 CDI86453.1 - 9.9 6.0 14.7 9.8 6.0 14.7 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Spt20 PF12090.8 CDI86454.1 - 0.00019 21.2 7.7 0.00022 20.9 7.7 1.3 1 0 0 1 1 1 1 Spt20 family CTC1 PF15489.6 CDI86454.1 - 0.00049 17.8 0.1 0.00053 17.7 0.1 1.0 1 0 0 1 1 1 1 CST, telomere maintenance, complex subunit CTC1 DUF2371 PF10177.9 CDI86454.1 - 0.011 15.9 0.3 0.021 15.0 0.3 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DUF572 PF04502.13 CDI86454.1 - 0.32 10.6 5.0 0.43 10.1 5.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4045 PF13254.6 CDI86454.1 - 0.54 9.9 8.0 0.65 9.6 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Senescence_reg PF04520.13 CDI86454.1 - 9 7.1 11.9 2.2e+02 2.6 11.9 2.1 1 1 0 1 1 1 0 Senescence regulator SNARE_assoc PF09335.11 CDI86455.1 - 2.9e-09 37.4 0.3 1e-08 35.7 0.0 2.0 2 1 0 2 2 2 1 SNARE associated Golgi protein SR-25 PF10500.9 CDI86455.1 - 7.5e-05 22.4 21.2 7.5e-05 22.4 21.2 1.5 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein eIF3_subunit PF08597.10 CDI86455.1 - 0.00045 20.2 1.1 0.00045 20.2 1.1 1.8 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit THRAP3_BCLAF1 PF15440.6 CDI86455.1 - 0.00088 18.4 14.2 0.0011 18.1 14.2 1.0 1 0 0 1 1 1 1 THRAP3/BCLAF1 family Suf PF05843.14 CDI86455.1 - 0.0033 17.4 10.2 0.005 16.9 10.2 1.3 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Apt1 PF10351.9 CDI86455.1 - 0.019 13.9 8.8 0.021 13.7 8.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain LAP1C PF05609.12 CDI86455.1 - 0.031 13.4 12.0 0.048 12.8 12.0 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CLN3 PF02487.17 CDI86455.1 - 0.073 12.1 1.9 0.12 11.4 1.9 1.6 1 0 0 1 1 1 0 CLN3 protein Ndc1_Nup PF09531.10 CDI86455.1 - 0.082 11.6 13.0 0.099 11.3 13.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOBP PF15279.6 CDI86455.1 - 0.1 13.2 14.4 0.16 12.5 14.4 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Peptidase_S64 PF08192.11 CDI86455.1 - 0.16 10.4 11.7 0.21 10.0 11.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 V_ATPase_I PF01496.19 CDI86455.1 - 0.2 9.5 6.1 0.24 9.3 6.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LMBR1 PF04791.16 CDI86455.1 - 0.36 9.7 3.4 0.45 9.4 3.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Rgp1 PF08737.10 CDI86455.1 - 0.96 8.5 15.6 1.4 8.0 15.6 1.2 1 0 0 1 1 1 0 Rgp1 RR_TM4-6 PF06459.12 CDI86455.1 - 1.1 9.0 15.3 1.9 8.3 15.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Raftlin PF15250.6 CDI86455.1 - 1.2 7.8 14.0 1.7 7.3 14.0 1.2 1 0 0 1 1 1 0 Raftlin DUF2417 PF10329.9 CDI86455.1 - 1.2 8.5 2.6 2.2 7.6 2.6 1.4 1 0 0 1 1 1 0 Region of unknown function (DUF2417) EOS1 PF12326.8 CDI86455.1 - 1.4 8.9 6.4 2.8 7.8 6.4 1.5 1 0 0 1 1 1 0 N-glycosylation protein Neur_chan_memb PF02932.16 CDI86455.1 - 1.9 8.5 9.9 2.9 7.9 9.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4614 PF15391.6 CDI86455.1 - 2 8.4 27.7 0.2 11.6 20.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) PA26 PF04636.13 CDI86455.1 - 2.2 7.1 12.4 3 6.7 12.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Caldesmon PF02029.15 CDI86455.1 - 2.3 6.9 21.0 3.2 6.4 21.0 1.1 1 0 0 1 1 1 0 Caldesmon MDFI PF15316.6 CDI86455.1 - 2.5 8.1 13.4 6.4 6.8 13.4 1.7 1 1 0 1 1 1 0 MyoD family inhibitor rRNA_processing PF08524.11 CDI86455.1 - 2.6 8.0 21.7 4.1 7.4 21.7 1.2 1 0 0 1 1 1 0 rRNA processing Connexin PF00029.19 CDI86455.1 - 2.7 7.7 7.0 4.5 7.0 7.0 1.4 1 0 0 1 1 1 0 Connexin DUF572 PF04502.13 CDI86455.1 - 3.2 7.3 18.0 3.2 7.3 16.9 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF572) Vma12 PF11712.8 CDI86455.1 - 3.3 7.8 11.4 0.045 13.8 1.9 2.3 2 1 1 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase SMYLE_N PF18615.1 CDI86455.1 - 5 6.6 16.6 0.9 9.0 12.6 1.6 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain PAT1 PF09770.9 CDI86455.1 - 5.2 5.2 19.2 7.7 4.7 19.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Het-C PF07217.11 CDI86455.1 - 5.3 5.5 9.4 6.6 5.1 9.4 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C NPR3 PF03666.13 CDI86455.1 - 5.7 5.6 16.7 7.6 5.2 16.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Band_7 PF01145.25 CDI86457.1 - 0.0099 15.9 0.5 0.0099 15.9 0.5 2.2 2 0 0 2 2 2 1 SPFH domain / Band 7 family DUF3752 PF12572.8 CDI86457.1 - 0.29 11.6 19.8 0.37 11.3 19.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) SprA-related PF12118.8 CDI86457.1 - 0.47 9.5 38.7 0.77 8.8 38.7 1.3 1 0 0 1 1 1 0 SprA-related family TFIIA PF03153.13 CDI86457.1 - 0.48 10.4 46.1 0.56 10.1 46.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spc7_N PF15402.6 CDI86457.1 - 0.74 8.0 29.2 0.89 7.7 29.2 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 RR_TM4-6 PF06459.12 CDI86457.1 - 0.75 9.6 19.8 0.86 9.4 19.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AF-4 PF05110.13 CDI86457.1 - 1.9 6.5 37.2 2.8 5.9 37.2 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CCSAP PF15748.5 CDI86457.1 - 2.2 8.4 32.8 2.7 8.1 32.8 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Spt20 PF12090.8 CDI86458.1 - 0.011 15.4 15.4 0.011 15.4 15.4 2.2 2 0 0 2 2 2 0 Spt20 family SOBP PF15279.6 CDI86458.1 - 0.3 11.7 9.5 0.4 11.2 9.5 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Lin-8 PF03353.15 CDI86458.1 - 0.41 10.2 14.4 0.61 9.6 14.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SLC12 PF03522.15 CDI86458.1 - 0.65 9.0 8.8 0.8 8.7 8.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF4569 PF15133.6 CDI86458.1 - 1.9 8.1 14.9 12 5.5 15.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4569) DUF4834 PF16118.5 CDI86458.1 - 2.1 9.3 16.6 6.9 7.7 9.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RCR PF12273.8 CDI86458.1 - 2.3 8.9 9.7 5.1 7.8 9.7 1.5 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red RRP36 PF06102.12 CDI86458.1 - 3.5 7.6 13.9 0.23 11.4 5.6 2.1 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 Plasmodium_Vir PF05795.11 CDI86458.1 - 5.5 6.3 4.9 7.7 5.8 4.9 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PAT1 PF09770.9 CDI86458.1 - 7.4 4.7 27.6 8.8 4.5 27.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF5523 PF17661.1 CDI86459.1 - 0.0009 19.0 27.8 0.0014 18.4 27.8 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5523) GEN1_C PF18380.1 CDI86459.1 - 0.0031 18.4 4.2 0.0031 18.4 4.2 2.1 2 0 0 2 2 2 1 Holliday junction resolvase Gen1 C-terminal domain Presenilin PF01080.17 CDI86459.1 - 0.0046 15.8 30.8 0.0055 15.5 30.8 1.0 1 0 0 1 1 1 1 Presenilin Exonuc_VII_L PF02601.15 CDI86459.1 - 0.0064 16.1 31.6 0.0073 15.9 31.6 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit MAT1 PF06391.13 CDI86459.1 - 0.013 15.3 38.0 0.18 11.6 17.0 2.0 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 ALMT PF11744.8 CDI86459.1 - 0.039 12.8 16.9 0.054 12.3 16.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter FYDLN_acid PF09538.10 CDI86459.1 - 0.046 14.4 19.0 0.13 13.0 3.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) SLC12 PF03522.15 CDI86459.1 - 0.14 11.2 27.0 0.17 10.8 27.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Rxt3 PF08642.10 CDI86459.1 - 0.2 12.4 18.4 0.24 12.2 4.4 2.1 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 RNA_pol_Rpc4 PF05132.14 CDI86459.1 - 0.3 11.5 25.7 0.64 10.4 6.7 2.1 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF1764 PF08576.10 CDI86459.1 - 0.32 11.9 24.1 2.2 9.2 7.2 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) CDC27 PF09507.10 CDI86459.1 - 0.34 10.2 31.6 0.39 10.0 31.6 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PBP1_TM PF14812.6 CDI86459.1 - 0.57 10.6 11.9 0.33 11.4 2.5 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Coatamer_beta_C PF07718.12 CDI86459.1 - 0.58 10.1 20.1 0.032 14.2 5.9 2.1 2 0 0 2 2 2 0 Coatomer beta C-terminal region CFIA_Pcf11 PF11526.8 CDI86459.1 - 0.66 10.5 26.4 1.8 9.1 9.1 2.2 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 EFTUD2 PF16004.5 CDI86459.1 - 0.79 10.3 29.2 1.8 9.2 10.5 2.1 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus DUF4776 PF16003.5 CDI86459.1 - 0.93 8.4 29.4 1.1 8.2 29.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) PPP4R2 PF09184.11 CDI86459.1 - 1.2 8.7 16.0 1.7 8.1 16.0 1.2 1 0 0 1 1 1 0 PPP4R2 BSMAP PF12280.8 CDI86459.1 - 1.9 8.6 25.1 4.2 7.5 8.4 2.1 2 0 0 2 2 2 0 Brain specific membrane anchored protein DUF3306 PF11748.8 CDI86459.1 - 2.5 9.0 32.0 0.52 11.2 9.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Hid1 PF12722.7 CDI86459.1 - 4.1 5.4 31.6 5 5.1 31.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DNA_pol_delta_4 PF04081.13 CDI86459.1 - 4.5 7.6 26.0 4.9 7.5 6.7 2.1 2 0 0 2 2 2 0 DNA polymerase delta, subunit 4 RuvC_III PF18541.1 CDI86459.1 - 4.7 7.1 26.4 5.4 6.9 8.6 2.1 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 CobT PF06213.12 CDI86459.1 - 5.1 6.4 44.4 2.8 7.3 16.5 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Apc15p PF05841.11 CDI86459.1 - 5.2 7.9 33.4 7.3 7.4 12.9 2.1 2 0 0 2 2 2 0 Apc15p protein Caldesmon PF02029.15 CDI86459.1 - 5.2 5.7 31.2 6.7 5.3 31.2 1.1 1 0 0 1 1 1 0 Caldesmon CD20 PF04103.15 CDI86459.1 - 5.5 7.1 12.7 0.45 10.6 1.7 2.1 2 0 0 2 2 2 0 CD20-like family PH_4 PF15404.6 CDI86459.1 - 7.4 6.3 20.7 1.7 8.4 5.2 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain DUF2722 PF10846.8 CDI86459.1 - 7.7 5.3 68.2 0.84 8.5 29.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DcuA_DcuB PF03605.14 CDI86459.1 - 9.4 5.0 14.7 3.3 6.5 3.5 2.1 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Pap_E4 PF02711.14 CDI86459.1 - 9.8 7.2 23.3 12 6.9 8.3 2.1 2 0 0 2 2 2 0 E4 protein DDRGK PF09756.9 CDI86459.1 - 9.8 5.7 40.7 1.7 8.2 11.6 2.1 2 0 0 2 2 2 0 DDRGK domain SR-25 PF10500.9 CDI86460.1 - 0.0022 17.6 27.4 0.0022 17.6 27.4 17.2 6 6 8 15 15 15 1 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI86460.1 - 0.0026 18.4 15.3 0.0026 18.4 15.3 21.8 5 5 11 17 17 17 1 Immortalisation up-regulated protein SprA-related PF12118.8 CDI86462.1 - 0.0018 17.5 35.0 0.0021 17.3 35.0 1.0 1 0 0 1 1 1 1 SprA-related family NicO PF03824.16 CDI86462.1 - 0.0023 17.4 6.0 0.0025 17.2 6.0 1.1 1 0 0 1 1 1 1 High-affinity nickel-transport protein Presenilin PF01080.17 CDI86462.1 - 0.58 8.9 20.3 0.67 8.7 20.3 1.1 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CDI86462.1 - 1.5 8.7 20.7 1.8 8.5 20.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) EMC3_TMCO1 PF01956.16 CDI86462.1 - 1.8 8.3 7.4 3.4 7.4 7.4 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like TFIIA PF03153.13 CDI86462.1 - 1.8 8.4 29.9 2.3 8.1 29.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EOS1 PF12326.8 CDI86462.1 - 2.5 8.0 13.6 3.3 7.6 13.6 1.3 1 0 0 1 1 1 0 N-glycosylation protein DUF4175 PF13779.6 CDI86462.1 - 3 5.6 17.1 2.9 5.7 17.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF755 PF05501.11 CDI86463.1 - 0.034 14.4 18.0 0.034 14.4 18.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF755) SR-25 PF10500.9 CDI86463.1 - 0.13 11.9 30.4 0.024 14.3 21.4 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4964 PF16334.5 CDI86463.1 - 0.6 9.7 0.0 0.6 9.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4964) RAP1 PF07218.11 CDI86463.1 - 2.9 6.1 10.4 3.4 5.8 10.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Menin PF05053.13 CDI86463.1 - 3.3 6.0 16.7 4.1 5.6 16.7 1.0 1 0 0 1 1 1 0 Menin DUF4175 PF13779.6 CDI86463.1 - 9.3 4.0 29.5 9.8 3.9 29.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Activator_LAG-3 PF11498.8 CDI86464.1 - 0.00023 20.3 25.2 0.0003 19.9 25.2 1.2 1 0 0 1 1 1 1 Transcriptional activator LAG-3 TFIIA PF03153.13 CDI86464.1 - 0.0057 16.7 31.5 0.0071 16.4 31.5 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit EIF4E-T PF10477.9 CDI86464.1 - 0.15 10.8 10.0 0.17 10.6 10.0 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Neur_chan_memb PF02932.16 CDI86464.1 - 1.1 9.2 5.7 1.5 8.9 5.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Neuregulin PF02158.15 CDI86464.1 - 2.3 7.5 12.7 2.8 7.2 12.4 1.3 1 1 0 1 1 1 0 Neuregulin intracellular region Mcm10 PF09332.11 CDI86464.1 - 3 7.2 14.1 4 6.8 14.1 1.1 1 0 0 1 1 1 0 Mcm10 replication factor PAT1 PF09770.9 CDI86464.1 - 5.2 5.2 22.6 6.1 5.0 22.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 UPF0560 PF10577.9 CDI86464.1 - 6.9 5.0 15.6 8.2 4.8 15.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 GREB1 PF15782.5 CDI86464.1 - 8.4 3.4 12.6 8.7 3.3 12.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer COMPASS-Shg1 PF05205.12 CDI86467.1 - 0.17 12.6 0.7 0.22 12.3 0.7 1.2 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 DUF2477 PF10631.9 CDI86467.1 - 1.3 9.6 9.0 1.8 9.2 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2477) Glutenin_hmw PF03157.13 CDI86468.1 - 0.0059 15.1 6.1 0.0074 14.8 6.1 1.1 1 0 0 1 1 1 1 High molecular weight glutenin subunit TerD PF02342.18 CDI86469.1 - 1.1e-05 25.1 0.0 6e-05 22.6 0.0 2.0 2 0 0 2 2 2 1 TerD domain PhoD PF09423.10 CDI86470.1 - 2.1e-08 33.6 0.1 6.6e-07 28.7 0.0 2.2 2 0 0 2 2 2 2 PhoD-like phosphatase COX4 PF02936.14 CDI86471.1 - 0.046 13.8 0.0 0.06 13.4 0.0 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV PWI PF01480.17 CDI86472.1 - 6.3e-29 100.1 0.0 8.6e-29 99.7 0.0 1.2 1 0 0 1 1 1 1 PWI domain DIRP PF06584.13 CDI86472.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 DIRP eIF3_p135 PF12807.7 CDI86473.1 - 3.9e-07 30.3 0.0 1.1e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 CDI86473.1 - 0.023 15.0 3.2 2.8 8.3 0.4 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3228 PF11539.8 CDI86474.1 - 1.6e-81 272.5 0.0 1.9e-81 272.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3228) Ribosomal_L22e PF01776.17 CDI86475.1 - 2e-44 150.4 2.1 2.3e-44 150.2 2.1 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family AMPK1_CBM PF16561.5 CDI86475.1 - 0.084 13.1 0.0 0.2 11.9 0.0 1.6 2 0 0 2 2 2 0 Glycogen recognition site of AMP-activated protein kinase DEAD PF00270.29 CDI86477.1 - 5.2e-38 130.6 0.0 1.4e-37 129.1 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI86477.1 - 1.2e-23 83.6 0.0 3.1e-11 43.6 0.0 3.1 2 1 1 3 3 3 2 Helicase conserved C-terminal domain DSPc PF00782.20 CDI86477.1 - 6.2e-09 35.8 0.0 1.1e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CBM_20 PF00686.19 CDI86477.1 - 0.044 13.7 0.0 0.27 11.2 0.0 2.1 2 0 0 2 2 2 0 Starch binding domain SPX PF03105.19 CDI86478.1 - 0.011 15.6 1.1 0.014 15.3 1.1 1.1 1 0 0 1 1 1 0 SPX domain DSS1_SEM1 PF05160.13 CDI86478.1 - 0.014 15.5 21.7 0.44 10.6 21.7 2.4 1 1 0 1 1 1 0 DSS1/SEM1 family Cwf_Cwc_15 PF04889.12 CDI86478.1 - 0.033 13.9 5.3 0.04 13.6 5.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein AIF_C PF14721.6 CDI86480.1 - 0.27 11.6 15.3 0.29 11.5 15.3 1.0 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term EFTUD2 PF16004.5 CDI86480.1 - 0.75 10.4 21.1 0.81 10.3 21.1 1.0 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus DUF3408 PF11888.8 CDI86480.1 - 1.7 8.8 19.6 1.7 8.8 19.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) CobT PF06213.12 CDI86480.1 - 2.2 7.6 27.8 2.3 7.6 27.8 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SelP_N PF04592.14 CDI86480.1 - 3.7 6.9 28.9 3.9 6.8 28.9 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Tim54 PF11711.8 CDI86480.1 - 4.1 6.1 18.1 4.3 6.0 18.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Coilin_N PF15862.5 CDI86480.1 - 4.2 7.2 21.7 5.3 6.8 21.7 1.2 1 0 0 1 1 1 0 Coilin N-terminus RR_TM4-6 PF06459.12 CDI86480.1 - 5.3 6.8 20.3 5.4 6.8 20.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4820 PF16091.5 CDI86480.1 - 6.2 6.1 14.7 7 5.9 14.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Paf1 PF03985.13 CDI86480.1 - 6.6 5.6 23.8 7.1 5.5 23.8 1.0 1 0 0 1 1 1 0 Paf1 DUF3464 PF11947.8 CDI86480.1 - 6.9 6.4 18.5 7.6 6.3 18.5 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 FAM60A PF15396.6 CDI86480.1 - 7.4 6.5 16.7 7.1 6.6 16.7 1.0 1 0 0 1 1 1 0 Protein Family FAM60A SpoIIP PF07454.11 CDI86480.1 - 8 5.8 22.1 8 5.8 22.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF3043 PF11241.8 CDI86480.1 - 8.1 6.4 15.1 8.7 6.3 15.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) EIIBC-GUT_N PF03612.14 CDI86480.1 - 8.7 6.0 17.3 10 5.8 17.3 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF1764 PF08576.10 CDI86480.1 - 8.7 7.3 16.2 11 7.0 16.2 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) CPSF100_C PF13299.6 CDI86480.1 - 9 6.5 17.2 9.1 6.4 17.2 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Pex14_N PF04695.13 CDI86480.1 - 9.4 6.9 32.2 11 6.6 32.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RskA PF10099.9 CDI86481.1 - 0.0038 17.5 19.3 0.0038 17.5 19.3 3.1 1 1 2 3 3 3 1 Anti-sigma-K factor rskA Dehydrin PF00257.19 CDI86481.1 - 0.0054 17.3 1.0 0.0054 17.3 1.0 2.7 2 1 0 2 2 2 1 Dehydrin FA_desaturase PF00487.24 CDI86481.1 - 0.019 14.8 0.2 0.061 13.2 0.0 1.7 2 0 0 2 2 2 0 Fatty acid desaturase GWT1 PF06423.12 CDI86481.1 - 0.055 13.6 0.1 0.055 13.6 0.1 2.0 1 1 1 2 2 2 0 GWT1 ETRAMP PF09716.10 CDI86481.1 - 0.078 13.1 0.0 0.078 13.1 0.0 2.5 2 1 1 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Spt20 PF12090.8 CDI86481.1 - 0.088 12.4 47.6 0.037 13.7 18.9 2.3 2 0 0 2 2 2 0 Spt20 family DUF4834 PF16118.5 CDI86481.1 - 0.67 10.9 17.3 2.1 9.4 4.6 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Ribosomal_60s PF00428.19 CDI86481.1 - 6.3 7.5 33.4 13 6.5 12.7 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein TERB2 PF15101.6 CDI86481.1 - 9.5 6.2 22.9 0.46 10.5 7.5 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 TFIIA PF03153.13 CDI86482.1 - 6.2e-07 29.8 35.7 9.6e-07 29.1 35.7 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF5427 PF10310.9 CDI86482.1 - 0.00033 19.7 24.7 0.00056 19.0 24.7 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5427) PAT1 PF09770.9 CDI86482.1 - 0.0025 16.2 29.2 0.0031 15.9 29.2 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Peptidase_S64 PF08192.11 CDI86482.1 - 0.022 13.2 10.1 0.025 13.1 10.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 Zip PF02535.22 CDI86482.1 - 0.024 13.9 4.2 0.031 13.5 4.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 CDI86482.1 - 0.037 13.0 7.3 0.07 12.1 7.3 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Ndc1_Nup PF09531.10 CDI86482.1 - 0.063 12.0 15.8 0.075 11.7 15.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SpoIIP PF07454.11 CDI86482.1 - 0.094 12.2 15.7 0.17 11.3 15.7 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Velvet PF11754.8 CDI86482.1 - 0.094 12.6 16.2 0.15 12.0 16.2 1.3 1 0 0 1 1 1 0 Velvet factor Hid1 PF12722.7 CDI86482.1 - 0.11 10.7 15.7 0.14 10.3 15.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.12 CDI86482.1 - 0.12 12.2 21.8 0.025 14.4 17.5 1.9 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 CDI86482.1 - 0.15 10.4 16.2 0.24 9.6 16.2 1.3 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI86482.1 - 0.34 9.9 19.7 0.52 9.3 19.7 1.3 1 0 0 1 1 1 0 Solute carrier family 12 DUF2828 PF11443.8 CDI86482.1 - 0.39 8.8 17.0 0.59 8.2 17.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) NPR3 PF03666.13 CDI86482.1 - 0.41 9.4 16.8 0.61 8.8 16.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Suf PF05843.14 CDI86482.1 - 0.56 10.1 23.6 1.5 8.8 23.6 1.7 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) GREB1 PF15782.5 CDI86482.1 - 0.56 7.3 17.6 0.7 7.0 17.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Plasmodium_Vir PF05795.11 CDI86482.1 - 0.74 9.2 6.2 1.1 8.6 6.2 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Spore_coat_CotO PF14153.6 CDI86482.1 - 0.92 9.4 29.5 0.14 12.1 25.0 1.9 2 0 0 2 2 2 0 Spore coat protein CotO DUF2052 PF09747.9 CDI86482.1 - 1.5 8.9 23.8 0.19 11.8 17.6 2.0 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) MMR1 PF08505.10 CDI86482.1 - 1.6 9.0 25.3 0.36 11.1 22.0 1.7 2 0 0 2 2 1 0 Mitochondrial Myo2 receptor-related protein EOS1 PF12326.8 CDI86482.1 - 1.6 8.7 11.6 0.63 9.9 8.6 1.9 2 0 0 2 2 2 0 N-glycosylation protein Membralin PF09746.9 CDI86482.1 - 1.6 7.7 11.8 2.5 7.1 11.8 1.3 1 0 0 1 1 1 0 Tumour-associated protein ALMT PF11744.8 CDI86482.1 - 1.8 7.3 16.6 2.9 6.6 16.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter SID-1_RNA_chan PF13965.6 CDI86482.1 - 2.1 6.7 7.1 2.8 6.2 7.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 HCO3_cotransp PF00955.21 CDI86482.1 - 2.4 6.9 9.2 3.4 6.4 9.2 1.1 1 0 0 1 1 1 0 HCO3- transporter family YjbH PF06082.11 CDI86482.1 - 2.5 6.8 14.4 3.3 6.4 14.4 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Presenilin PF01080.17 CDI86482.1 - 2.8 6.6 28.7 0.21 10.3 24.0 1.4 2 0 0 2 2 2 0 Presenilin Tim54 PF11711.8 CDI86482.1 - 3.8 6.2 17.0 0.5 9.1 13.2 1.5 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF4175 PF13779.6 CDI86482.1 - 3.9 5.3 50.4 7 4.4 50.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CCDC53 PF10152.9 CDI86482.1 - 4 7.8 27.3 0.096 13.1 20.2 1.8 2 1 0 2 2 2 0 Subunit CCDC53 of WASH complex DUF4746 PF15928.5 CDI86482.1 - 4.7 6.6 16.0 0.18 11.2 10.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Otopetrin PF03189.13 CDI86482.1 - 5.2 5.8 10.2 7.2 5.3 10.2 1.2 1 0 0 1 1 1 0 Otopetrin Med15 PF09606.10 CDI86482.1 - 7.7 5.1 53.5 0.017 13.8 39.8 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal V_ATPase_I PF01496.19 CDI86482.1 - 8.6 4.1 22.1 1 7.2 17.6 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF3527 PF12043.8 CDI86483.1 - 3 7.3 25.0 3.4 7.1 25.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) DUF3807 PF12720.7 CDI86483.1 - 4.1 7.6 44.0 5.7 7.2 44.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) RR_TM4-6 PF06459.12 CDI86483.1 - 7.4 6.3 39.7 9 6.0 39.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sin_N PF04801.13 CDI86484.1 - 0.003 16.8 13.7 0.0035 16.6 13.7 1.0 1 0 0 1 1 1 1 Sin-like protein conserved region Spt20 PF12090.8 CDI86484.1 - 0.0069 16.0 9.7 0.0069 16.0 9.7 1.9 2 0 0 2 2 2 1 Spt20 family DUF389 PF04087.14 CDI86484.1 - 0.03 14.4 1.0 0.62 10.1 1.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF389) TFIIA PF03153.13 CDI86484.1 - 0.11 12.5 14.8 0.13 12.2 14.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Shadoo PF14999.6 CDI86484.1 - 0.3 11.2 12.8 0.11 12.6 10.6 1.5 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective SR-25 PF10500.9 CDI86484.1 - 1.2 8.7 19.2 0.6 9.7 11.2 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Androgen_recep PF02166.16 CDI86484.1 - 1.2 7.9 24.2 0.17 10.7 5.9 2.1 2 0 0 2 2 2 0 Androgen receptor Menin PF05053.13 CDI86484.1 - 1.2 7.4 16.2 1.4 7.2 16.2 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 CDI86484.1 - 1.9 7.2 11.7 2.5 6.8 11.7 1.1 1 0 0 1 1 1 0 Presenilin PAP1 PF08601.10 CDI86484.1 - 2.3 7.8 15.9 2.9 7.5 15.9 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 MRI PF15325.6 CDI86484.1 - 4.4 8.4 11.5 0.19 12.8 1.3 2.4 1 1 1 2 2 2 0 Modulator of retrovirus infection SUIM_assoc PF16619.5 CDI86484.1 - 4.5 7.4 21.0 19 5.4 21.0 2.3 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Conotoxin PF02950.17 CDI86484.1 - 5.8 8.0 12.6 0.1 13.6 2.7 2.5 2 1 1 3 3 3 0 Conotoxin tRNA_synt_1c_R2 PF04557.15 CDI86484.1 - 8.9 7.3 9.0 9.1 7.3 1.9 2.2 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 TMA7 PF09072.10 CDI86484.1 - 9.4 7.2 12.0 4.7 8.1 5.0 2.3 2 0 0 2 2 2 0 Translation machinery associated TMA7 Auxin_canalis PF05703.11 CDI86485.1 - 0.058 13.3 18.7 0.07 13.1 18.7 1.0 1 0 0 1 1 1 0 Auxin canalisation PIP5K PF01504.18 CDI86485.1 - 0.32 10.2 8.9 0.43 9.8 8.9 1.4 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Utp14 PF04615.13 CDI86485.1 - 1.1 7.7 22.6 1.2 7.6 22.6 1.0 1 0 0 1 1 1 0 Utp14 protein DUF243 PF03103.17 CDI86485.1 - 1.3 9.4 27.1 0.27 11.6 20.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF243) Dapper PF15268.6 CDI86485.1 - 1.7 7.4 29.8 1.9 7.2 29.8 1.0 1 0 0 1 1 1 0 Dapper CCSAP PF15748.5 CDI86485.1 - 2.5 8.2 24.2 3.1 7.9 24.2 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated UPRTase PF14681.6 CDI86485.1 - 2.5 7.5 11.7 4.1 6.8 11.7 1.5 1 1 0 1 1 1 0 Uracil phosphoribosyltransferase Peptidase_S41 PF03572.18 CDI86485.1 - 2.6 7.6 8.3 4 7.0 8.2 1.4 1 1 0 1 1 1 0 Peptidase family S41 DUF5095 PF17016.5 CDI86485.1 - 3.1 7.4 9.8 3.7 7.2 9.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5095) Lin-8 PF03353.15 CDI86485.1 - 3.2 7.2 23.8 3.7 7.0 23.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2076 PF09849.9 CDI86485.1 - 4.9 7.1 40.5 6.9 6.6 40.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CCDC24 PF15669.5 CDI86488.1 - 2.8 7.8 7.6 3.3 7.6 7.6 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Utp14 PF04615.13 CDI86489.1 - 0.33 9.5 5.8 0.48 8.9 5.8 1.1 1 0 0 1 1 1 0 Utp14 protein Spt20 PF12090.8 CDI86489.1 - 0.53 9.9 37.8 0.023 14.3 12.2 3.1 3 0 0 3 3 3 0 Spt20 family baeRF_family10 PF18854.1 CDI86489.1 - 0.59 10.4 6.9 3.1 8.0 0.0 2.8 3 0 0 3 3 3 0 Bacterial archaeo-eukaryotic release factor family 10 TFIIA PF03153.13 CDI86490.1 - 0.01 15.8 30.1 0.014 15.4 30.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SARAF PF06682.12 CDI86490.1 - 0.045 13.4 22.4 0.058 13.0 22.4 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis RskA PF10099.9 CDI86490.1 - 0.69 10.2 34.3 0.74 10.1 22.5 2.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF2076 PF09849.9 CDI86490.1 - 0.83 9.6 33.5 1.3 9.0 33.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Utp14 PF04615.13 CDI86490.1 - 2.5 6.6 20.2 2.9 6.4 20.2 1.0 1 0 0 1 1 1 0 Utp14 protein PAT1 PF09770.9 CDI86490.1 - 6.2 5.0 22.1 7.3 4.7 22.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Dicty_REP PF05086.12 CDI86490.1 - 8.9 4.1 10.4 11 3.9 10.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF2681 PF10883.8 CDI86490.1 - 8.9 6.8 20.8 1.2 9.5 7.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Med3 PF11593.8 CDI86492.1 - 0.0071 15.6 13.3 0.0066 15.7 13.3 1.1 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal DUF2967 PF11179.8 CDI86492.1 - 0.017 13.2 16.2 0.02 13.0 16.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) TFIIA PF03153.13 CDI86492.1 - 0.095 12.7 14.9 0.11 12.5 14.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PPDFL PF15060.6 CDI86492.1 - 0.099 13.2 6.3 0.14 12.7 6.3 1.2 1 0 0 1 1 1 0 Differentiation and proliferation regulator RR_TM4-6 PF06459.12 CDI86492.1 - 0.12 12.1 7.8 0.14 12.0 7.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FTZ PF03867.14 CDI86492.1 - 0.16 11.5 7.2 0.21 11.1 7.2 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region LAP1C PF05609.12 CDI86492.1 - 0.6 9.1 11.0 0.69 8.9 11.0 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DRY_EERY PF09750.9 CDI86492.1 - 0.73 10.1 9.8 1 9.6 9.8 1.2 1 0 0 1 1 1 0 Alternative splicing regulator SR-25 PF10500.9 CDI86492.1 - 2.1 7.9 19.7 6 6.4 19.7 1.6 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 CDI86492.1 - 4.8 5.8 11.7 5.4 5.7 11.7 1.1 1 0 0 1 1 1 0 Presenilin DUF3464 PF11947.8 CDI86492.1 - 6.1 6.6 8.6 8.5 6.1 8.6 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 ProRS-C_1 PF09180.11 CDI86493.1 - 6.3e-31 106.4 0.0 9e-31 105.9 0.0 1.2 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal AP2 PF00847.20 CDI86494.1 - 2.6e-06 27.6 1.6 0.0074 16.5 0.7 2.4 2 0 0 2 2 2 2 AP2 domain Presenilin PF01080.17 CDI86495.1 - 0.35 9.6 5.9 0.35 9.6 5.9 1.1 1 0 0 1 1 1 0 Presenilin DUF1180 PF06679.12 CDI86495.1 - 0.35 11.3 4.1 0.43 11.0 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF1980 PF09323.10 CDI86495.1 - 0.46 10.4 6.1 0.56 10.1 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) O-antigen_lig PF13425.6 CDI86495.1 - 0.78 8.5 4.1 0.95 8.2 4.1 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Scs3p PF10261.9 CDI86495.1 - 1 8.8 5.2 1.1 8.7 5.2 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM ABC2_membrane_2 PF12679.7 CDI86495.1 - 1.1 8.4 6.2 1.4 8.1 6.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein CemA PF03040.14 CDI86495.1 - 1.1 9.1 11.3 1.3 8.9 11.3 1.0 1 0 0 1 1 1 0 CemA family DUF4834 PF16118.5 CDI86495.1 - 1.6 9.7 16.7 7.5 7.6 16.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Ctr PF04145.15 CDI86495.1 - 1.8 9.2 4.3 2.2 8.9 4.3 1.1 1 0 0 1 1 1 0 Ctr copper transporter family CLN3 PF02487.17 CDI86495.1 - 4.2 6.3 7.6 4.1 6.3 7.6 1.0 1 0 0 1 1 1 0 CLN3 protein Skp1 PF01466.19 CDI86498.1 - 2e-13 50.2 4.7 2e-12 47.0 0.7 2.4 2 1 0 2 2 2 2 Skp1 family, dimerisation domain DUF755 PF05501.11 CDI86498.1 - 0.034 14.4 3.3 0.037 14.3 3.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Pex14_N PF04695.13 CDI86499.1 - 0.015 15.9 17.1 0.015 15.9 17.1 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3464 PF11947.8 CDI86499.1 - 0.032 14.0 9.9 0.037 13.8 9.9 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF2722 PF10846.8 CDI86499.1 - 0.038 12.9 29.8 0.039 12.9 29.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) EIIBC-GUT_N PF03612.14 CDI86499.1 - 0.13 12.0 10.9 0.14 11.9 10.9 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Tox-WTIP PF15654.6 CDI86499.1 - 0.18 12.2 0.1 0.22 12.0 0.1 1.1 1 0 0 1 1 1 0 Toxin with a conserved tryptophan and TIP tripeptide motif MMU163 PF17119.5 CDI86499.1 - 0.35 10.0 6.6 0.39 9.8 6.6 1.0 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Consortin_C PF15281.6 CDI86499.1 - 0.37 10.8 2.9 0.42 10.6 2.9 1.2 1 0 0 1 1 1 0 Consortin C-terminus T2SSC PF11356.8 CDI86499.1 - 0.44 10.4 9.5 0.51 10.2 9.5 1.1 1 0 0 1 1 1 0 Type II secretion system protein C CPSF100_C PF13299.6 CDI86499.1 - 0.45 10.7 10.6 0.45 10.7 10.6 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal HSNSD PF12062.8 CDI86499.1 - 0.47 9.1 6.5 0.46 9.2 6.5 1.0 1 0 0 1 1 1 0 heparan sulfate-N-deacetylase FAM176 PF14851.6 CDI86499.1 - 0.48 10.1 9.1 0.51 10.0 9.1 1.0 1 0 0 1 1 1 0 FAM176 family Peptidase_S49_N PF08496.10 CDI86499.1 - 0.5 10.4 11.3 0.56 10.3 11.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF5308 PF17233.2 CDI86499.1 - 0.52 10.5 11.6 0.54 10.5 11.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF1764 PF08576.10 CDI86499.1 - 0.58 11.1 11.0 0.62 11.0 11.0 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Peroxin-13_N PF04088.13 CDI86499.1 - 0.71 10.1 7.7 0.85 9.9 7.7 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region RIC3 PF15361.6 CDI86499.1 - 0.82 10.1 9.3 0.91 9.9 9.3 1.0 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Connexin PF00029.19 CDI86499.1 - 0.83 9.4 11.0 0.84 9.3 11.0 1.0 1 0 0 1 1 1 0 Connexin RNA_pol_Rbc25 PF08292.12 CDI86499.1 - 1 9.6 7.9 1.3 9.2 7.9 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 CSG2 PF16965.5 CDI86499.1 - 1.1 8.1 8.2 1.1 8.1 8.2 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Pal1 PF08316.11 CDI86499.1 - 1.2 9.9 5.6 1.2 9.9 5.6 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein Presenilin PF01080.17 CDI86499.1 - 1.3 7.8 16.8 1.3 7.7 16.8 1.0 1 0 0 1 1 1 0 Presenilin HNOBA PF07701.14 CDI86499.1 - 1.3 8.4 13.7 1.5 8.2 13.7 1.0 1 0 0 1 1 1 0 Heme NO binding associated Rxt3 PF08642.10 CDI86499.1 - 1.4 9.7 7.5 1.5 9.6 7.5 1.1 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Orf78 PF06024.12 CDI86499.1 - 1.4 9.3 9.1 1.8 8.9 9.1 1.2 1 0 0 1 1 1 0 Orf78 (ac78) PH_4 PF15404.6 CDI86499.1 - 1.6 8.4 9.8 1.9 8.3 9.8 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain Hydin_ADK PF17213.3 CDI86499.1 - 1.7 8.9 11.5 2.1 8.6 11.5 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain MRP-S26 PF14943.6 CDI86499.1 - 1.7 8.5 16.1 1.9 8.4 16.1 1.0 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 MCU PF04678.13 CDI86499.1 - 1.8 8.6 9.3 1.8 8.6 9.3 1.0 1 0 0 1 1 1 0 Mitochondrial calcium uniporter TFIIA PF03153.13 CDI86499.1 - 2 8.3 36.7 1.9 8.4 36.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zip PF02535.22 CDI86499.1 - 2.1 7.5 8.6 2 7.5 8.6 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter CCDC53 PF10152.9 CDI86499.1 - 2.1 8.7 15.2 2.3 8.6 15.2 1.0 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Gti1_Pac2 PF09729.9 CDI86499.1 - 2.2 8.3 11.9 2.3 8.3 11.9 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family ORC5_C PF14630.6 CDI86499.1 - 2.3 7.7 9.3 2.7 7.5 9.3 1.0 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus EOS1 PF12326.8 CDI86499.1 - 2.4 8.1 9.4 2.5 8.0 9.4 1.1 1 0 0 1 1 1 0 N-glycosylation protein MPM1 PF17234.2 CDI86499.1 - 2.4 8.4 16.9 2.6 8.3 16.9 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 DDHD PF02862.17 CDI86499.1 - 2.6 8.1 13.8 2.7 8.1 13.8 1.0 1 0 0 1 1 1 0 DDHD domain DUF4824 PF16106.5 CDI86499.1 - 2.7 7.2 15.0 3.1 7.0 15.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4824) DUF3347 PF11827.8 CDI86499.1 - 2.9 8.0 15.7 3.1 7.9 15.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Kei1 PF08552.11 CDI86499.1 - 3.1 7.6 9.7 3.3 7.5 9.7 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Pex26 PF07163.12 CDI86499.1 - 3.2 7.0 15.1 3.3 6.9 15.1 1.1 1 0 0 1 1 1 0 Pex26 protein SpoIIP PF07454.11 CDI86499.1 - 3.2 7.1 16.8 3.3 7.1 16.8 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Peptidase_U57 PF05582.12 CDI86499.1 - 3.2 6.9 11.4 3.3 6.9 11.4 1.0 1 0 0 1 1 1 0 YabG peptidase U57 ATG22 PF11700.8 CDI86499.1 - 3.2 6.3 5.4 3.2 6.3 5.4 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like RBM39linker PF15519.6 CDI86499.1 - 3.4 8.8 13.9 3.7 8.7 13.9 1.1 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein TMEM51 PF15345.6 CDI86499.1 - 3.5 7.4 17.0 4.3 7.1 17.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 Neur_chan_memb PF02932.16 CDI86499.1 - 3.8 7.5 11.2 3.8 7.5 11.2 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM91_C PF14648.6 CDI86499.1 - 3.8 6.2 9.2 3.7 6.3 9.2 1.0 1 0 0 1 1 1 0 FAM91 C-terminus PIP5K PF01504.18 CDI86499.1 - 3.9 6.6 13.2 4 6.6 13.2 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2367 PF10164.9 CDI86499.1 - 4 8.0 8.4 5.7 7.5 8.4 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) Ureide_permease PF07168.11 CDI86499.1 - 4.4 6.0 8.4 4.6 5.9 8.4 1.0 1 0 0 1 1 1 0 Ureide permease ALMT PF11744.8 CDI86499.1 - 4.4 6.0 11.3 4.4 6.0 11.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Folate_carrier PF01770.18 CDI86499.1 - 4.6 5.9 9.3 5 5.7 9.3 1.0 1 0 0 1 1 1 0 Reduced folate carrier DcuA_DcuB PF03605.14 CDI86499.1 - 4.7 6.0 5.6 5.1 5.9 5.6 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF4638 PF15472.6 CDI86499.1 - 4.8 6.8 12.1 5.1 6.7 12.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) RR_TM4-6 PF06459.12 CDI86499.1 - 4.9 6.9 14.8 4.9 6.9 14.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3408 PF11888.8 CDI86499.1 - 4.9 7.3 16.6 5.4 7.2 16.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Eapp_C PF10238.9 CDI86499.1 - 5 7.2 16.7 5.4 7.1 16.7 1.0 1 0 0 1 1 1 0 E2F-associated phosphoprotein API5 PF05918.11 CDI86499.1 - 5.1 5.8 14.4 5 5.8 14.4 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Membralin PF09746.9 CDI86499.1 - 5.4 6.0 8.5 5.3 6.0 8.5 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF2126 PF09899.9 CDI86499.1 - 5.5 4.9 11.3 5.6 4.9 11.3 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) PigN PF04987.14 CDI86499.1 - 5.6 5.7 8.6 6 5.6 8.6 1.0 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) BRF1 PF07741.13 CDI86499.1 - 5.9 7.3 13.4 6.9 7.1 13.4 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Ctr PF04145.15 CDI86499.1 - 6.1 7.4 10.6 6.6 7.3 10.6 1.0 1 0 0 1 1 1 0 Ctr copper transporter family DUF3405 PF11885.8 CDI86499.1 - 6.2 5.3 13.9 7.1 5.1 13.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) SID-1_RNA_chan PF13965.6 CDI86499.1 - 6.2 5.1 8.1 6.2 5.1 8.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PepSY_TM PF03929.16 CDI86499.1 - 6.3 6.4 9.1 6 6.4 9.1 1.0 1 0 0 1 1 1 0 PepSY-associated TM region MecA PF05389.12 CDI86499.1 - 7.4 6.1 13.9 7.8 6.1 13.9 1.0 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) BNR_3 PF13859.6 CDI86499.1 - 7.7 5.7 8.2 8.7 5.5 8.2 1.0 1 0 0 1 1 1 0 BNR repeat-like domain CLN3 PF02487.17 CDI86499.1 - 7.8 5.4 12.4 8 5.4 12.4 1.0 1 0 0 1 1 1 0 CLN3 protein SLC12 PF03522.15 CDI86499.1 - 8.2 5.3 15.2 8.4 5.3 15.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 CDI86499.1 - 8.5 6.3 12.0 8.9 6.2 12.0 1.0 1 0 0 1 1 1 0 Protein Family FAM60A MTP18 PF10558.9 CDI86499.1 - 8.6 6.3 7.5 9.7 6.1 7.5 1.1 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) Glt_symporter PF03616.14 CDI86499.1 - 9.2 4.8 6.2 9.8 4.7 6.2 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter RED_N PF07808.13 CDI86499.1 - 9.3 5.8 17.3 11 5.5 17.3 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region Tim54 PF11711.8 CDI86499.1 - 9.3 4.9 14.1 9.7 4.9 14.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 G0-G1_switch_2 PF15103.6 CDI86499.1 - 9.4 6.7 13.8 11 6.4 13.8 1.1 1 0 0 1 1 1 0 G0/G1 switch protein 2 Sec62 PF03839.16 CDI86499.1 - 9.5 5.7 11.5 9.8 5.6 11.5 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 UPF0524 PF15823.5 CDI86499.1 - 9.5 5.5 9.4 10 5.5 9.4 1.1 1 0 0 1 1 1 0 UPF0524 of C3orf70 DUF702 PF05142.12 CDI86499.1 - 9.7 6.7 16.7 11 6.5 16.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) RNA_pol_Rpc34 PF05158.12 CDI86500.1 - 1.8e-13 50.6 4.6 9.8e-05 21.9 0.2 4.0 1 1 2 3 3 3 3 RNA polymerase Rpc34 subunit UBA_3 PF09288.10 CDI86500.1 - 0.06 13.2 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Hid1 PF12722.7 CDI86501.1 - 7.4 4.6 47.0 7.7 4.5 47.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RLL PF10036.9 CDI86502.1 - 0.00064 19.6 3.8 0.00083 19.3 3.8 1.2 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein SAPS PF04499.15 CDI86502.1 - 0.011 14.6 4.0 0.012 14.5 4.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF1387 PF07139.11 CDI86502.1 - 0.096 12.4 7.8 0.11 12.2 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Zip PF02535.22 CDI86502.1 - 0.096 11.9 3.7 0.094 11.9 3.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter ALMT PF11744.8 CDI86502.1 - 0.19 10.5 0.9 0.23 10.2 0.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 CDI86502.1 - 0.21 11.6 4.1 0.23 11.5 4.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Connexin PF00029.19 CDI86502.1 - 0.26 11.0 2.4 0.27 11.0 2.4 1.2 1 0 0 1 1 1 0 Connexin Spt20 PF12090.8 CDI86502.1 - 0.29 10.7 16.8 0.4 10.3 16.8 1.2 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 CDI86502.1 - 0.49 9.1 7.9 0.52 9.0 7.9 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI86502.1 - 0.98 9.2 11.3 1.2 8.9 11.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 CDI86502.1 - 0.99 7.4 4.5 0.94 7.5 4.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3464 PF11947.8 CDI86502.1 - 1.5 8.6 5.9 2.1 8.1 5.9 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Androgen_recep PF02166.16 CDI86502.1 - 2.3 7.0 12.6 3 6.6 12.6 1.3 1 0 0 1 1 1 0 Androgen receptor CobT PF06213.12 CDI86502.1 - 2.4 7.5 13.8 3.3 7.0 13.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT V_ATPase_I PF01496.19 CDI86502.1 - 6 4.6 6.8 6.2 4.6 6.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RskA PF10099.9 CDI86503.1 - 0.03 14.6 1.9 0.038 14.3 1.9 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA GRP PF07172.11 CDI86503.1 - 0.13 13.0 0.6 0.23 12.2 0.6 1.4 1 0 0 1 1 1 0 Glycine rich protein family CDC45 PF02724.14 CDI86503.1 - 0.13 10.5 4.1 0.14 10.4 4.1 1.0 1 0 0 1 1 1 0 CDC45-like protein MCM_bind PF09739.9 CDI86503.1 - 0.16 10.4 2.6 0.19 10.2 2.6 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Dsh_C PF12316.8 CDI86503.1 - 0.46 10.8 3.0 0.51 10.7 3.0 1.0 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Ribosomal_60s PF00428.19 CDI86503.1 - 4.9 7.8 17.9 5.2 7.7 4.7 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein RNA_pol_Rpc4 PF05132.14 CDI86504.1 - 0.59 10.6 17.0 0.63 10.5 17.0 1.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 TFB6 PF17110.5 CDI86504.1 - 0.75 9.5 18.0 0.81 9.4 18.0 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH FAM176 PF14851.6 CDI86504.1 - 2.4 7.8 16.8 2.8 7.6 16.8 1.1 1 0 0 1 1 1 0 FAM176 family DUF1764 PF08576.10 CDI86504.1 - 2.7 8.9 20.9 3.3 8.7 20.9 1.0 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) CobT PF06213.12 CDI86504.1 - 2.9 7.2 31.3 3.2 7.1 31.3 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FYDLN_acid PF09538.10 CDI86504.1 - 4.5 8.0 13.7 6.5 7.5 13.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) ATAD4 PF15321.6 CDI86504.1 - 4.6 8.7 14.6 5.6 8.4 14.6 1.3 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 SpoIIP PF07454.11 CDI86504.1 - 5 6.5 26.1 5.5 6.4 26.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) AIF_C PF14721.6 CDI86504.1 - 5.6 7.3 17.5 6.9 7.0 17.5 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Tim54 PF11711.8 CDI86504.1 - 5.6 5.6 21.1 6.1 5.5 21.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Eapp_C PF10238.9 CDI86504.1 - 6.2 6.9 23.5 7.4 6.6 23.5 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF3408 PF11888.8 CDI86504.1 - 8 6.6 23.5 9.2 6.4 23.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Coilin_N PF15862.5 CDI86504.1 - 8.6 6.2 24.8 13 5.5 24.8 1.3 1 0 0 1 1 1 0 Coilin N-terminus DUF3381 PF11861.8 CDI86504.1 - 9.2 6.0 29.0 11 5.7 29.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) RR_TM4-6 PF06459.12 CDI86504.1 - 9.3 6.0 24.5 9.9 5.9 24.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 YABBY PF04690.13 CDI86504.1 - 9.5 6.8 18.8 11 6.6 18.8 1.0 1 0 0 1 1 1 0 YABBY protein MMU163 PF17119.5 CDI86504.1 - 9.7 5.3 13.0 11 5.1 13.0 1.0 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis SR-25 PF10500.9 CDI86505.1 - 1.2e-07 31.6 7.4 1.8e-07 31.1 7.4 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein TMEM51 PF15345.6 CDI86505.1 - 1.4e-05 25.1 12.4 1.7e-05 24.8 12.4 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 MecA PF05389.12 CDI86505.1 - 0.00043 20.0 3.2 0.00048 19.8 3.2 1.1 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) TCP PF03634.13 CDI86505.1 - 0.00043 20.9 11.0 0.00051 20.6 11.0 1.1 1 0 0 1 1 1 1 TCP family transcription factor RskA PF10099.9 CDI86505.1 - 0.0011 19.3 5.8 0.0015 18.9 5.8 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA MID_MedPIWI PF18296.1 CDI86505.1 - 0.0014 18.5 9.1 0.002 18.0 9.1 1.2 1 0 0 1 1 1 1 MID domain of medPIWI CCSAP PF15748.5 CDI86505.1 - 0.0024 18.1 11.6 0.0033 17.6 11.6 1.2 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated Velvet PF11754.8 CDI86505.1 - 0.0026 17.8 14.3 0.0031 17.5 14.3 1.0 1 0 0 1 1 1 1 Velvet factor CCDC53 PF10152.9 CDI86505.1 - 0.0037 17.7 8.2 0.0048 17.3 8.2 1.2 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex DUF572 PF04502.13 CDI86505.1 - 0.0054 16.4 10.1 0.0063 16.2 10.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Presenilin PF01080.17 CDI86505.1 - 0.0074 15.1 15.0 0.0093 14.8 15.0 1.0 1 0 0 1 1 1 1 Presenilin Conotoxin PF02950.17 CDI86505.1 - 0.0076 17.2 22.1 0.0076 17.2 22.1 1.9 2 1 0 2 2 1 1 Conotoxin eIF-3_zeta PF05091.12 CDI86505.1 - 0.0078 15.2 13.5 0.0079 15.2 13.5 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) STAC2_u1 PF16664.5 CDI86505.1 - 0.0081 16.6 8.8 0.012 16.0 8.8 1.3 1 0 0 1 1 1 1 Unstructured on SH3 and cysteine-rich domain-containing protein 2 DUF3402 PF11882.8 CDI86505.1 - 0.01 15.0 11.3 0.011 14.9 11.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) CBP_BcsG PF11658.8 CDI86505.1 - 0.011 14.2 8.2 0.013 13.9 8.2 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Tim54 PF11711.8 CDI86505.1 - 0.012 14.4 4.1 0.011 14.5 4.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SID-1_RNA_chan PF13965.6 CDI86505.1 - 0.012 14.0 2.7 0.013 13.9 2.7 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI86505.1 - 0.015 13.3 10.4 0.016 13.2 10.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2076 PF09849.9 CDI86505.1 - 0.015 15.3 23.7 0.018 15.1 23.7 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Corona_nucleoca PF00937.18 CDI86505.1 - 0.016 14.3 15.6 0.019 14.0 15.6 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein K_trans PF02705.16 CDI86505.1 - 0.016 13.7 1.8 0.02 13.4 1.8 1.1 1 0 0 1 1 1 0 K+ potassium transporter PAT1 PF09770.9 CDI86505.1 - 0.017 13.5 16.5 0.016 13.5 16.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RED_N PF07808.13 CDI86505.1 - 0.017 14.7 9.9 0.019 14.6 9.9 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region GRP PF07172.11 CDI86505.1 - 0.018 15.7 0.4 0.032 14.9 0.4 1.5 1 0 0 1 1 1 0 Glycine rich protein family TFB6 PF17110.5 CDI86505.1 - 0.019 14.7 2.8 0.024 14.4 2.8 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Folate_carrier PF01770.18 CDI86505.1 - 0.02 13.6 3.8 0.02 13.6 3.8 1.2 1 0 0 1 1 1 0 Reduced folate carrier PAP_PilO PF06864.12 CDI86505.1 - 0.036 12.9 11.2 0.044 12.6 11.2 1.2 1 0 0 1 1 1 0 Pilin accessory protein (PilO) DUF4050 PF13259.6 CDI86505.1 - 0.036 14.4 10.0 0.05 13.9 10.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Peptidase_S49_N PF08496.10 CDI86505.1 - 0.039 14.0 6.2 0.054 13.6 6.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FHIPEP PF00771.20 CDI86505.1 - 0.042 12.3 6.5 0.049 12.1 6.5 1.0 1 0 0 1 1 1 0 FHIPEP family CSG2 PF16965.5 CDI86505.1 - 0.047 12.6 9.4 0.054 12.4 9.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2828 PF11443.8 CDI86505.1 - 0.048 11.7 8.0 0.049 11.7 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4175 PF13779.6 CDI86505.1 - 0.061 11.2 29.4 0.064 11.2 29.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Dpy19 PF10034.9 CDI86505.1 - 0.062 11.5 3.8 0.071 11.3 3.8 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation DUF2126 PF09899.9 CDI86505.1 - 0.062 11.4 4.7 0.06 11.4 4.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Neur_chan_memb PF02932.16 CDI86505.1 - 0.062 13.3 9.6 0.069 13.2 9.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3405 PF11885.8 CDI86505.1 - 0.063 11.9 6.5 0.068 11.8 6.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) DUF913 PF06025.12 CDI86505.1 - 0.069 12.1 5.4 0.09 11.7 5.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Suf PF05843.14 CDI86505.1 - 0.072 13.1 15.4 0.091 12.7 15.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DcuA_DcuB PF03605.14 CDI86505.1 - 0.077 11.9 1.4 0.078 11.9 1.4 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter ABC2_membrane_2 PF12679.7 CDI86505.1 - 0.087 12.1 3.1 0.089 12.1 3.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein SpoIIP PF07454.11 CDI86505.1 - 0.095 12.1 12.3 0.13 11.7 12.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PUCC PF03209.15 CDI86505.1 - 0.12 11.4 4.5 0.14 11.1 4.5 1.1 1 0 0 1 1 1 0 PUCC protein Scs3p PF10261.9 CDI86505.1 - 0.15 11.6 2.4 0.2 11.1 2.4 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DcuC PF03606.15 CDI86505.1 - 0.15 10.5 0.9 0.16 10.4 0.9 1.0 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier PAP_RNA-bind PF04926.15 CDI86505.1 - 0.16 11.6 8.4 0.18 11.4 8.4 1.1 1 0 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain ALG3 PF05208.13 CDI86505.1 - 0.19 11.1 3.6 0.24 10.8 3.6 1.1 1 0 0 1 1 1 0 ALG3 protein RBM39linker PF15519.6 CDI86505.1 - 0.23 12.6 12.2 0.42 11.7 12.2 1.4 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein PigN PF04987.14 CDI86505.1 - 0.3 9.9 10.6 0.53 9.1 10.6 1.3 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) DUF3381 PF11861.8 CDI86505.1 - 0.31 10.8 15.4 0.43 10.4 15.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) SART-1 PF03343.13 CDI86505.1 - 0.35 9.4 13.8 0.38 9.3 13.8 1.1 1 0 0 1 1 1 0 SART-1 family DUF5327 PF17261.2 CDI86505.1 - 0.44 11.3 22.4 0.057 14.2 17.9 1.7 2 0 0 2 2 1 0 Family of unknown function (DUF5327) FAM176 PF14851.6 CDI86505.1 - 0.49 10.1 9.8 0.048 13.3 5.5 1.5 2 0 0 2 2 1 0 FAM176 family MCU PF04678.13 CDI86505.1 - 0.51 10.4 10.5 0.58 10.2 10.5 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Connexin PF00029.19 CDI86505.1 - 0.52 10.0 13.2 0.54 10.0 12.5 1.3 1 1 0 1 1 1 0 Connexin DUF1645 PF07816.11 CDI86505.1 - 0.6 10.7 14.8 1.1 9.8 1.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) O-antigen_lig PF13425.6 CDI86505.1 - 0.63 8.8 2.1 0.79 8.4 2.1 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein BRF1 PF07741.13 CDI86505.1 - 0.76 10.2 10.8 2 8.8 10.8 1.6 2 0 0 2 2 1 0 Brf1-like TBP-binding domain Peroxin-13_N PF04088.13 CDI86505.1 - 0.9 9.8 12.2 0.71 10.1 11.1 1.4 1 1 0 1 1 1 0 Peroxin 13, N-terminal region DUF3408 PF11888.8 CDI86505.1 - 0.97 9.6 13.3 0.2 11.8 10.1 1.4 2 0 0 2 2 1 0 Protein of unknown function (DUF3408) CobT PF06213.12 CDI86505.1 - 1.1 8.6 21.6 0.057 12.8 16.6 1.4 2 0 0 2 2 1 0 Cobalamin biosynthesis protein CobT DUF2227 PF09988.9 CDI86505.1 - 1.1 9.1 3.3 1.5 8.7 3.3 1.2 1 0 0 1 1 1 0 Uncharacterized metal-binding protein (DUF2227) AAA_23 PF13476.6 CDI86505.1 - 1.1 9.7 15.9 1.3 9.5 15.9 1.2 1 0 0 1 1 1 0 AAA domain ALMT PF11744.8 CDI86505.1 - 1.3 7.8 9.4 1.5 7.6 9.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Het-C PF07217.11 CDI86505.1 - 1.3 7.5 8.6 1.3 7.4 8.6 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C WASH-7_C PF14746.6 CDI86505.1 - 1.7 8.3 15.2 2.5 7.7 15.2 1.3 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal Nha1_C PF08619.10 CDI86505.1 - 1.8 7.7 17.2 3 6.9 17.2 1.4 1 1 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus PH_4 PF15404.6 CDI86505.1 - 2.2 8.1 10.6 0.56 10.0 7.7 1.4 2 0 0 2 2 1 0 Pleckstrin homology domain Ureide_permease PF07168.11 CDI86505.1 - 2.3 6.9 4.8 3 6.5 4.8 1.2 1 0 0 1 1 1 0 Ureide permease DUF4770 PF15994.5 CDI86505.1 - 2.4 8.4 17.3 0.31 11.3 13.5 1.4 2 0 0 2 2 1 0 Domain of unknown function (DUF4770) Zip PF02535.22 CDI86505.1 - 2.5 7.3 6.4 3.4 6.8 6.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RPA43_OB PF17875.1 CDI86505.1 - 2.6 8.7 11.5 2.3 8.9 10.4 1.4 2 0 0 2 2 1 0 RPA43 OB domain in RNA Pol I DUF4746 PF15928.5 CDI86505.1 - 2.6 7.4 8.5 3.1 7.1 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PepSY_TM PF03929.16 CDI86505.1 - 2.7 7.6 9.4 3.6 7.2 9.4 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Senescence_reg PF04520.13 CDI86505.1 - 3.2 8.6 12.5 4.3 8.1 12.5 1.2 1 0 0 1 1 1 0 Senescence regulator DUF3276 PF11680.8 CDI86505.1 - 3.7 7.7 9.9 2.6 8.2 8.1 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF3276) MPM1 PF17234.2 CDI86505.1 - 4.4 7.5 20.9 0.27 11.5 15.0 1.8 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Orf78 PF06024.12 CDI86505.1 - 4.8 7.5 16.7 24 5.3 0.0 2.1 1 1 1 2 2 2 0 Orf78 (ac78) FliP PF00813.20 CDI86505.1 - 5 7.0 6.4 6.6 6.6 6.4 1.1 1 0 0 1 1 1 0 FliP family MitoNEET_N PF10660.9 CDI86506.1 - 0.1 12.6 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus DUF572 PF04502.13 CDI86508.1 - 1.1 8.8 25.9 2.7 7.5 9.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) DUF3739 PF12545.8 CDI86508.1 - 1.2 9.6 6.4 0.22 12.0 2.5 1.8 2 0 0 2 2 2 0 Filamentous haemagglutinin family outer membrane protein MMR1 PF08505.10 CDI86508.1 - 1.2 9.3 35.5 1.2 9.4 12.6 3.2 3 0 0 3 3 3 0 Mitochondrial Myo2 receptor-related protein DUF3807 PF12720.7 CDI86508.1 - 9.2 6.5 38.8 9.2 6.5 17.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) DUF2722 PF10846.8 CDI86509.1 - 0.0021 17.1 11.0 0.0021 17.1 11.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI86509.1 - 0.014 15.1 18.6 0.014 15.0 18.6 1.0 1 0 0 1 1 1 0 Spt20 family eIF-3c_N PF05470.12 CDI86509.1 - 0.067 11.5 2.7 0.066 11.5 2.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Spore_YhcN_YlaJ PF09580.10 CDI86509.1 - 0.35 11.0 7.6 0.43 10.6 7.6 1.1 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) RLL PF10036.9 CDI86509.1 - 0.35 10.7 9.3 0.34 10.7 9.3 1.0 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein TFIIA PF03153.13 CDI86509.1 - 0.41 10.6 17.5 0.47 10.4 17.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM176 PF14851.6 CDI86509.1 - 0.42 10.3 3.4 0.46 10.2 3.4 1.1 1 0 0 1 1 1 0 FAM176 family Roughex PF06020.11 CDI86509.1 - 0.87 8.6 13.7 0.94 8.5 13.7 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Presenilin PF01080.17 CDI86509.1 - 0.94 8.2 6.9 0.82 8.4 6.9 1.0 1 0 0 1 1 1 0 Presenilin Sin_N PF04801.13 CDI86509.1 - 1 8.5 12.5 1.1 8.4 12.5 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Pex14_N PF04695.13 CDI86509.1 - 1 10.0 15.0 1.5 9.5 15.0 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DDHD PF02862.17 CDI86509.1 - 1.1 9.4 5.5 0.98 9.5 5.5 1.1 1 0 0 1 1 1 0 DDHD domain Suf PF05843.14 CDI86509.1 - 1.6 8.7 7.8 1.5 8.8 7.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CPSF100_C PF13299.6 CDI86509.1 - 2.4 8.3 9.0 2.8 8.1 9.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Neur_chan_memb PF02932.16 CDI86509.1 - 2.6 8.0 4.1 2.8 8.0 4.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TERB2 PF15101.6 CDI86509.1 - 3.4 7.7 10.9 4.2 7.4 10.9 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 BAF1_ABF1 PF04684.13 CDI86509.1 - 3.7 6.5 13.3 4.2 6.3 13.3 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor UPF0560 PF10577.9 CDI86509.1 - 3.8 5.9 11.3 4.3 5.7 11.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4834 PF16118.5 CDI86509.1 - 3.8 8.5 9.0 4.8 8.2 9.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3464 PF11947.8 CDI86509.1 - 4.3 7.1 7.9 5.3 6.8 7.9 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 CLN3 PF02487.17 CDI86509.1 - 5.1 6.0 4.4 5.7 5.9 4.4 1.1 1 0 0 1 1 1 0 CLN3 protein Hid1 PF12722.7 CDI86509.1 - 6.2 4.8 5.6 6.1 4.8 5.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Coilin_N PF15862.5 CDI86509.1 - 8.4 6.2 10.3 11 5.8 10.3 1.2 1 0 0 1 1 1 0 Coilin N-terminus V_ATPase_I PF01496.19 CDI86509.1 - 9.6 4.0 6.7 9.6 4.0 6.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GREB1 PF15782.5 CDI86509.1 - 9.9 3.1 7.0 9.8 3.1 7.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AAA_11 PF13086.6 CDI86510.1 - 1.2e-20 74.4 20.0 5.3e-16 59.2 1.2 4.6 2 1 2 4 4 4 2 AAA domain UPF0564 PF10595.9 CDI86510.1 - 0.0027 16.8 34.7 0.0027 16.8 34.7 3.1 2 1 0 2 2 2 1 Uncharacterised protein family UPF0564 SRP-alpha_N PF04086.13 CDI86510.1 - 0.076 12.9 65.3 0.05 13.5 18.8 3.1 3 0 0 3 3 3 0 Signal recognition particle, alpha subunit, N-terminal RskA PF10099.9 CDI86510.1 - 7.2 6.9 51.4 0.11 12.8 8.0 3.7 2 1 1 3 3 3 0 Anti-sigma-K factor rskA Med9 PF07544.13 CDI86511.1 - 0.48 10.6 4.7 15 5.7 0.3 3.2 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 IFT57 PF10498.9 CDI86511.1 - 0.88 8.5 6.6 3.2 6.6 0.1 3.4 4 0 0 4 4 4 0 Intra-flagellar transport protein 57 Muted PF14942.6 CDI86511.1 - 4.6 7.6 8.3 0.58 10.5 0.5 3.0 3 0 0 3 3 3 0 Organelle biogenesis, Muted-like protein Helicase_C_2 PF13307.6 CDI86513.1 - 4.1e-37 128.0 1.5 1.9e-33 116.0 0.0 3.1 3 0 0 3 3 3 2 Helicase C-terminal domain DEAD_2 PF06733.15 CDI86513.1 - 2.7e-30 105.3 0.1 1.2e-29 103.2 0.0 2.1 2 0 0 2 2 2 1 DEAD_2 DEAD PF00270.29 CDI86513.1 - 4.9e-05 23.2 0.3 0.0005 19.9 0.3 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CDI86513.1 - 0.0031 17.5 4.2 1.5 8.8 4.4 2.9 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit PRCH PF03967.13 CDI86513.1 - 0.06 13.6 0.5 1.1 9.5 0.1 3.0 3 0 0 3 3 3 0 Photosynthetic reaction centre, H-chain N-terminal region FliT PF05400.13 CDI86514.1 - 2.3 9.1 9.9 0.64 10.9 0.3 3.3 2 1 0 2 2 2 0 Flagellar protein FliT PACT_coil_coil PF10495.9 CDI86514.1 - 6.9 7.3 6.7 2.2 8.9 0.4 3.4 4 0 0 4 4 4 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein Ntox1 PF15500.6 CDI86516.1 - 0.47 10.8 4.3 2.6 8.5 0.2 3.3 2 0 0 2 2 2 0 Putative RNase-like toxin, toxin_1 Mito_carr PF00153.27 CDI86518.1 - 9.4e-30 102.4 0.5 2.9e-14 52.7 0.1 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein DUF4632 PF15451.6 CDI86518.1 - 0.087 12.9 3.0 7.6 6.7 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4632) BSP_II PF05432.11 CDI86519.1 - 0.0039 16.9 36.6 0.0042 16.8 36.6 1.0 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Mpp10 PF04006.12 CDI86519.1 - 0.16 10.3 29.4 0.18 10.2 29.4 1.0 1 0 0 1 1 1 0 Mpp10 protein DNA_pol_phi PF04931.13 CDI86519.1 - 0.24 9.4 29.1 0.26 9.4 29.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi PepSY_2 PF13670.6 CDI86519.1 - 0.36 10.8 20.9 0.63 10.1 1.0 2.1 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain BUD22 PF09073.10 CDI86519.1 - 0.39 10.0 29.1 0.42 9.9 29.1 1.0 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 CDI86519.1 - 1.5 7.0 31.3 1.6 6.9 31.3 1.0 1 0 0 1 1 1 0 Nop14-like family RskA PF10099.9 CDI86519.1 - 4.5 7.5 21.0 19 5.5 21.0 1.8 1 1 0 1 1 1 0 Anti-sigma-K factor rskA CobT PF06213.12 CDI86519.1 - 7.8 5.8 34.8 10 5.4 34.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SDA1 PF05285.12 CDI86519.1 - 9.2 5.6 34.6 10 5.4 34.6 1.1 1 0 0 1 1 1 0 SDA1 DUF3292 PF11696.8 CDI86520.1 - 0.0044 15.5 5.9 0.0044 15.5 5.9 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3292) Sin_N PF04801.13 CDI86520.1 - 0.011 14.9 24.6 0.016 14.5 24.6 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region UvrD-helicase PF00580.21 CDI86520.1 - 0.02 14.4 13.3 0.022 14.3 13.3 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Presenilin PF01080.17 CDI86520.1 - 0.023 13.5 13.7 0.026 13.3 13.7 1.1 1 0 0 1 1 1 0 Presenilin DDHD PF02862.17 CDI86520.1 - 0.04 14.1 8.2 0.05 13.8 8.2 1.1 1 0 0 1 1 1 0 DDHD domain CCSAP PF15748.5 CDI86520.1 - 0.19 11.9 16.3 0.22 11.7 16.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Ndc1_Nup PF09531.10 CDI86520.1 - 0.21 10.2 15.2 0.22 10.2 15.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Neur_chan_memb PF02932.16 CDI86520.1 - 0.25 11.4 13.0 0.32 11.0 13.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region VIT1 PF01988.19 CDI86520.1 - 0.29 11.0 9.9 0.83 9.5 10.0 1.7 1 1 0 1 1 1 0 VIT family ALMT PF11744.8 CDI86520.1 - 0.29 9.9 8.5 0.31 9.8 8.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Endostatin PF06482.11 CDI86520.1 - 0.42 10.0 13.4 0.51 9.8 13.4 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin O-antigen_lig PF13425.6 CDI86520.1 - 0.68 8.6 1.4 0.76 8.5 1.4 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PAT1 PF09770.9 CDI86520.1 - 0.79 7.9 33.1 0.92 7.7 33.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Exonuc_VII_L PF02601.15 CDI86520.1 - 0.86 9.1 20.8 0.96 9.0 20.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Hid1 PF12722.7 CDI86520.1 - 0.92 7.5 12.7 1.1 7.3 12.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LMBR1 PF04791.16 CDI86520.1 - 0.93 8.3 8.6 0.99 8.2 8.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Auxin_canalis PF05703.11 CDI86520.1 - 1 9.3 5.6 1.2 9.0 5.6 1.2 1 0 0 1 1 1 0 Auxin canalisation SLC12 PF03522.15 CDI86520.1 - 1.3 7.9 15.9 1.7 7.6 15.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CSG2 PF16965.5 CDI86520.1 - 2 7.2 4.5 2.8 6.8 4.5 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator V_ATPase_I PF01496.19 CDI86520.1 - 2.1 6.2 19.7 2.7 5.8 19.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BBS2_N PF14781.6 CDI86520.1 - 2.9 7.8 12.6 0.3 11.0 1.2 2.9 1 1 2 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal FAM60A PF15396.6 CDI86520.1 - 3 7.8 14.3 4.3 7.3 14.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF913 PF06025.12 CDI86520.1 - 3.8 6.4 14.9 9.4 5.1 14.7 1.6 1 1 1 2 2 2 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 CDI86520.1 - 3.9 7.2 18.5 5.6 6.7 18.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Het-C PF07217.11 CDI86520.1 - 3.9 5.9 9.0 4.8 5.6 9.0 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C CAML PF14963.6 CDI86520.1 - 4 7.5 6.6 1.7 8.7 3.7 1.6 1 1 1 2 2 2 0 Calcium signal-modulating cyclophilin ligand Paramyxo_ncap PF00973.19 CDI86520.1 - 8.3 5.2 7.9 9.6 5.0 7.9 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein AF-4 PF05110.13 CDI86523.1 - 0.00073 17.8 19.1 0.00073 17.8 19.1 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein SR-25 PF10500.9 CDI86523.1 - 0.0017 18.0 24.3 0.0024 17.6 24.3 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein GREB1 PF15782.5 CDI86523.1 - 0.053 10.7 21.8 0.053 10.7 21.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MMR1 PF08505.10 CDI86523.1 - 0.057 13.7 22.2 0.057 13.7 22.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Slu7 PF11708.8 CDI86523.1 - 0.1 12.3 17.4 0.11 12.2 17.4 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor TFIIA PF03153.13 CDI86523.1 - 0.11 12.5 43.1 0.12 12.3 43.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 CDI86523.1 - 0.11 11.3 17.3 0.12 11.3 17.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain FAM76 PF16046.5 CDI86523.1 - 0.12 11.7 18.9 0.12 11.7 18.9 1.1 1 0 0 1 1 1 0 FAM76 protein DUF4692 PF15763.5 CDI86523.1 - 0.13 12.8 14.6 0.13 12.7 14.6 1.2 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Mem_trans PF03547.18 CDI86523.1 - 0.13 10.6 10.5 0.13 10.6 10.5 1.2 1 0 0 1 1 1 0 Membrane transport protein EPL1 PF10513.9 CDI86523.1 - 0.14 12.6 19.0 0.19 12.1 19.0 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like CCSAP PF15748.5 CDI86523.1 - 0.14 12.3 20.3 0.16 12.1 20.3 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PNISR PF15996.5 CDI86523.1 - 0.2 11.9 20.3 0.26 11.6 20.3 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Nha1_C PF08619.10 CDI86523.1 - 0.23 10.6 20.2 0.25 10.5 20.2 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Lin-8 PF03353.15 CDI86523.1 - 0.28 10.7 26.2 0.3 10.6 26.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist FAM60A PF15396.6 CDI86523.1 - 0.31 11.0 15.5 0.31 11.0 15.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A TMEM51 PF15345.6 CDI86523.1 - 0.31 10.8 23.9 0.35 10.7 23.9 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 Presenilin PF01080.17 CDI86523.1 - 0.37 9.5 23.8 0.37 9.5 23.8 1.2 1 0 0 1 1 1 0 Presenilin Afi1 PF07792.12 CDI86523.1 - 0.49 10.9 17.4 0.6 10.6 17.4 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CDC45 PF02724.14 CDI86523.1 - 0.49 8.6 14.6 0.54 8.5 14.6 1.1 1 0 0 1 1 1 0 CDC45-like protein CCDC106 PF15794.5 CDI86523.1 - 0.52 10.0 22.2 0.67 9.6 22.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DDRGK PF09756.9 CDI86523.1 - 0.54 9.8 17.2 0.63 9.6 17.2 1.1 1 0 0 1 1 1 0 DDRGK domain Connexin PF00029.19 CDI86523.1 - 0.58 9.9 12.5 0.71 9.6 12.5 1.1 1 0 0 1 1 1 0 Connexin SARAF PF06682.12 CDI86523.1 - 0.62 9.7 15.3 0.69 9.5 15.3 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis NPR3 PF03666.13 CDI86523.1 - 0.62 8.8 19.2 0.66 8.7 19.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MPM1 PF17234.2 CDI86523.1 - 0.69 10.1 22.7 0.89 9.8 22.7 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 SLC12 PF03522.15 CDI86523.1 - 0.73 8.8 20.3 0.7 8.9 20.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4366 PF14283.6 CDI86523.1 - 0.79 9.8 10.0 1.3 9.1 10.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) EBP50_C PF09007.11 CDI86523.1 - 0.94 10.5 21.8 1.4 9.9 21.8 1.4 1 0 0 1 1 1 0 EBP50, C-terminal LMBR1 PF04791.16 CDI86523.1 - 0.97 8.3 9.5 0.99 8.2 9.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein RSB_motif PF16294.5 CDI86523.1 - 1 9.7 13.6 1.6 9.1 13.6 1.3 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif Draxin PF15550.6 CDI86523.1 - 1 9.1 14.4 1.2 9.0 14.4 1.0 1 0 0 1 1 1 0 Draxin Peptidase_S64 PF08192.11 CDI86523.1 - 1.1 7.7 20.7 0.99 7.8 20.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 CDRT4 PF15213.6 CDI86523.1 - 1.1 9.8 8.5 1.6 9.3 8.5 1.3 1 0 0 1 1 1 0 CMT1A duplicated region transcript 4 protein Gti1_Pac2 PF09729.9 CDI86523.1 - 1.2 9.2 19.1 1.3 9.1 19.1 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4471 PF14740.6 CDI86523.1 - 1.2 8.3 12.0 1.2 8.3 12.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) SpoIIP PF07454.11 CDI86523.1 - 1.2 8.5 18.4 1.4 8.3 18.4 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CSRNP_N PF16019.5 CDI86523.1 - 1.3 8.9 18.7 1.5 8.7 18.7 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF4746 PF15928.5 CDI86523.1 - 1.3 8.3 11.8 1.4 8.3 11.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) ALMT PF11744.8 CDI86523.1 - 1.4 7.7 19.8 1.5 7.6 19.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DDHD PF02862.17 CDI86523.1 - 1.7 8.7 20.1 2 8.5 20.1 1.2 1 0 0 1 1 1 0 DDHD domain Membralin PF09746.9 CDI86523.1 - 1.8 7.5 12.5 1.7 7.6 12.5 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF908 PF06012.12 CDI86523.1 - 2 7.7 20.4 2.1 7.7 20.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SKA1 PF07160.12 CDI86523.1 - 2.2 8.1 19.3 2.3 8.0 19.3 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 BORG_CEP PF14957.6 CDI86523.1 - 2.3 9.4 17.5 2.8 9.1 17.5 1.2 1 0 0 1 1 1 0 Cdc42 effector Tim54 PF11711.8 CDI86523.1 - 2.5 6.8 17.0 2.8 6.6 17.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 MAT1 PF06391.13 CDI86523.1 - 2.5 7.9 21.5 2.7 7.8 21.5 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 BAF1_ABF1 PF04684.13 CDI86523.1 - 2.5 7.1 27.4 2.7 6.9 27.4 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Pet20 PF08692.10 CDI86523.1 - 2.9 8.6 9.7 3.8 8.2 9.7 1.2 1 0 0 1 1 1 0 Mitochondrial protein Pet20 DUF755 PF05501.11 CDI86523.1 - 3.1 8.1 41.9 1.7 8.9 40.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF755) PAT1 PF09770.9 CDI86523.1 - 3.1 6.0 33.0 3.2 5.9 33.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GPCR_chapero_1 PF11904.8 CDI86523.1 - 3.1 7.1 12.0 3.1 7.1 12.0 1.1 1 0 0 1 1 1 0 GPCR-chaperone Pkinase_fungal PF17667.1 CDI86523.1 - 3.1 6.5 11.6 3 6.5 11.6 1.1 1 0 0 1 1 1 0 Fungal protein kinase Plasmodium_Vir PF05795.11 CDI86523.1 - 3.5 6.9 12.3 3.6 6.9 12.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF1635 PF07795.11 CDI86523.1 - 3.6 7.4 24.5 4.7 7.0 24.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) PPL5 PF18168.1 CDI86523.1 - 3.6 6.8 14.6 3.8 6.7 14.6 1.1 1 0 0 1 1 1 0 Prim-pol family 5 CAML PF14963.6 CDI86523.1 - 3.9 7.5 10.7 4.2 7.4 10.7 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Bud13 PF09736.9 CDI86523.1 - 3.9 7.8 19.6 4.5 7.6 19.6 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Miga PF10265.9 CDI86523.1 - 4.2 6.2 20.8 4.3 6.2 20.8 1.0 1 0 0 1 1 1 0 Mitoguardin Mcm10 PF09332.11 CDI86523.1 - 4.3 6.7 21.6 4.3 6.7 21.6 1.1 1 0 0 1 1 1 0 Mcm10 replication factor DUF4638 PF15472.6 CDI86523.1 - 4.4 7.0 14.8 4.8 6.8 14.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) RR_TM4-6 PF06459.12 CDI86523.1 - 4.6 7.0 19.1 4.6 7.0 19.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CLN3 PF02487.17 CDI86523.1 - 4.7 6.1 16.1 5.2 6.0 16.1 1.1 1 0 0 1 1 1 0 CLN3 protein Zip PF02535.22 CDI86523.1 - 5.1 6.2 13.9 6.4 5.9 13.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 CDI86523.1 - 5.2 5.9 17.3 5.9 5.8 17.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) UPF0560 PF10577.9 CDI86523.1 - 5.3 5.4 25.2 6.2 5.2 25.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 MDM10 PF12519.8 CDI86523.1 - 5.7 5.7 16.8 6 5.6 16.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 MDFI PF15316.6 CDI86523.1 - 5.7 7.0 15.9 7.5 6.6 15.9 1.3 1 0 0 1 1 1 0 MyoD family inhibitor DAG_kinase_N PF14513.6 CDI86523.1 - 5.7 7.1 20.1 6.6 6.9 20.1 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus TYW3 PF02676.14 CDI86523.1 - 7 6.0 14.1 8.4 5.7 14.1 1.1 1 0 0 1 1 1 0 Methyltransferase TYW3 Otopetrin PF03189.13 CDI86523.1 - 7.3 5.3 14.1 7.2 5.3 14.1 1.1 1 0 0 1 1 1 0 Otopetrin PCNP PF15473.6 CDI86523.1 - 7.5 7.3 17.3 10 6.8 17.3 1.2 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family Band_3_cyto PF07565.13 CDI86523.1 - 8.2 6.1 21.4 9.9 5.9 21.4 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain LptF_LptG PF03739.14 CDI86523.1 - 9.1 5.0 6.9 9.7 4.9 6.9 1.0 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG DUF4647 PF15504.6 CDI86523.1 - 9.2 5.3 21.4 9 5.3 21.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DUF755 PF05501.11 CDI86524.1 - 0.00021 21.5 24.0 0.00021 21.5 24.0 15.7 8 3 4 12 12 12 1 Domain of unknown function (DUF755) Glyco_transf_41 PF13844.6 CDI86524.1 - 0.00074 18.1 3.1 0.00074 18.1 3.1 6.6 4 2 0 5 5 5 1 Glycosyl transferase family 41 DUF1645 PF07816.11 CDI86524.1 - 0.0055 17.3 9.1 0.0055 17.3 9.1 10.2 2 1 4 7 7 7 1 Protein of unknown function (DUF1645) RskA PF10099.9 CDI86524.1 - 0.011 16.0 3.3 0.011 16.0 3.3 16.4 4 3 7 11 11 11 0 Anti-sigma-K factor rskA zf-LITAF-like PF10601.9 CDI86524.1 - 1.7 8.9 23.4 8.5 6.7 18.2 3.1 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain DUF952 PF06108.12 CDI86525.1 - 0.18 11.8 1.6 15 5.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF952) Spt20 PF12090.8 CDI86526.1 - 0.00064 19.4 13.6 0.00064 19.4 13.6 5.5 4 2 0 4 4 4 1 Spt20 family DUF755 PF05501.11 CDI86526.1 - 0.0049 17.1 4.0 0.0049 17.1 4.0 8.8 6 2 2 8 8 8 2 Domain of unknown function (DUF755) eIF-3_zeta PF05091.12 CDI86526.1 - 0.23 10.4 21.7 1.1 8.2 4.8 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3405 PF11885.8 CDI86526.1 - 0.41 9.2 11.7 0.95 8.0 1.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3405) DUF4484 PF14831.6 CDI86527.1 - 1.3e-06 28.6 8.8 1.3e-06 28.6 8.8 3.5 3 1 0 3 3 3 1 Domain of unknown function (DUF4484) UPF0564 PF10595.9 CDI86527.1 - 0.0023 17.1 15.6 0.0023 17.1 15.6 3.1 3 0 0 3 3 3 2 Uncharacterised protein family UPF0564 SAPS PF04499.15 CDI86527.1 - 0.36 9.6 34.7 0.62 8.8 5.7 2.3 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 CDI86527.1 - 1.3 7.2 38.8 0.013 13.8 6.6 3.2 3 0 0 3 3 3 0 CDC45-like protein CAF1 PF04857.20 CDI86527.1 - 3.3 6.8 37.2 0.069 12.3 3.5 3.4 3 0 0 3 3 3 0 CAF1 family ribonuclease DUF4834 PF16118.5 CDI86528.1 - 7.4e-06 26.9 4.6 0.093 13.7 3.5 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) SR-25 PF10500.9 CDI86528.1 - 0.00032 20.4 12.4 0.00049 19.8 12.4 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 CDI86528.1 - 0.00064 20.0 1.7 0.00064 20.0 1.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF755) PNISR PF15996.5 CDI86528.1 - 0.0019 18.5 17.9 0.0023 18.2 17.9 1.1 1 0 0 1 1 1 1 Arginine/serine-rich protein PNISR DUF2572 PF10833.8 CDI86528.1 - 0.0035 17.2 0.3 0.0035 17.2 0.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2572) DUF4692 PF15763.5 CDI86528.1 - 0.0038 17.7 4.5 0.0038 17.7 4.5 2.1 1 1 1 2 2 2 1 Regulator of human erythroid cell expansion (RHEX) ANAPC_CDC26 PF10471.9 CDI86528.1 - 0.0041 17.9 31.3 0.14 13.0 10.2 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex APC subunit CDC26 Neur_chan_memb PF02932.16 CDI86528.1 - 0.0067 16.5 3.2 0.0094 16.0 3.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region RskA PF10099.9 CDI86528.1 - 0.0072 16.6 1.0 0.0072 16.6 1.0 2.5 1 1 1 2 2 1 1 Anti-sigma-K factor rskA Nop53 PF07767.11 CDI86528.1 - 0.0088 15.5 23.2 0.011 15.2 23.2 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Spore_YhcN_YlaJ PF09580.10 CDI86528.1 - 0.0092 16.1 5.1 0.013 15.6 5.1 1.2 1 0 0 1 1 1 1 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) PGA2 PF07543.12 CDI86528.1 - 0.0094 15.9 0.4 0.0094 15.9 0.4 2.4 2 1 0 2 2 1 1 Protein trafficking PGA2 Activator_LAG-3 PF11498.8 CDI86528.1 - 0.013 14.5 22.1 0.014 14.4 15.1 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 XRCC4 PF06632.12 CDI86528.1 - 0.016 14.1 13.4 0.021 13.7 13.4 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF1180 PF06679.12 CDI86528.1 - 0.018 15.4 3.9 0.018 15.4 3.9 2.2 1 1 1 2 2 1 0 Protein of unknown function (DUF1180) Wzy_C PF04932.15 CDI86528.1 - 0.024 14.3 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 O-Antigen ligase DUF2681 PF10883.8 CDI86528.1 - 0.032 14.6 0.3 0.032 14.6 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF2852 PF11014.8 CDI86528.1 - 0.035 14.3 2.5 0.44 10.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) SLC12 PF03522.15 CDI86528.1 - 0.041 12.9 9.3 0.055 12.5 9.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SURF2 PF05477.11 CDI86528.1 - 0.086 12.5 11.1 0.12 12.1 11.1 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) ALMT PF11744.8 CDI86528.1 - 0.092 11.6 10.8 0.11 11.3 10.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter GRP PF07172.11 CDI86528.1 - 0.18 12.5 5.4 0.21 12.3 0.9 2.4 2 1 0 2 2 2 0 Glycine rich protein family AF-4 PF05110.13 CDI86528.1 - 0.18 9.9 23.4 0.22 9.6 10.5 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Zip PF02535.22 CDI86528.1 - 0.2 10.8 12.2 2.6 7.2 12.0 2.0 1 1 0 1 1 1 0 ZIP Zinc transporter Spt20 PF12090.8 CDI86528.1 - 0.24 11.0 29.4 0.041 13.5 13.1 2.1 2 0 0 2 2 2 0 Spt20 family Cytadhesin_P30 PF07271.11 CDI86528.1 - 0.27 10.8 12.2 1.5 8.4 1.0 2.1 2 0 0 2 2 2 0 Cytadhesin P30/P32 Maf1 PF09174.10 CDI86528.1 - 0.46 10.6 6.6 2 8.6 0.7 2.1 2 0 0 2 2 2 0 Maf1 regulator TMEM100 PF16311.5 CDI86528.1 - 0.46 10.1 2.8 0.61 9.7 0.3 2.2 2 0 0 2 2 2 0 Transmembrane protein 100 Tmemb_9 PF05434.11 CDI86528.1 - 0.51 10.2 13.1 1.4 8.8 3.5 2.7 2 1 0 2 2 2 0 TMEM9 EMC3_TMCO1 PF01956.16 CDI86528.1 - 0.58 9.9 6.4 3.7 7.2 0.1 2.1 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like FAM176 PF14851.6 CDI86528.1 - 0.63 9.7 17.8 0.026 14.2 2.8 2.1 1 1 0 2 2 2 0 FAM176 family Ndc1_Nup PF09531.10 CDI86528.1 - 0.67 8.6 8.8 0.82 8.3 8.8 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PI3K_1B_p101 PF10486.9 CDI86528.1 - 0.69 7.6 8.9 0.84 7.3 8.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF572 PF04502.13 CDI86528.1 - 0.75 9.4 17.0 0.92 9.1 17.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SARAF PF06682.12 CDI86528.1 - 0.86 9.2 10.8 4.4 6.9 10.8 1.9 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Apt1 PF10351.9 CDI86528.1 - 0.98 8.2 12.9 1.2 7.9 12.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain G0-G1_switch_2 PF15103.6 CDI86528.1 - 0.98 9.9 16.0 0.51 10.8 6.6 2.2 1 1 1 2 2 2 0 G0/G1 switch protein 2 MPM1 PF17234.2 CDI86528.1 - 1.1 9.5 20.3 1.7 8.9 6.2 2.0 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 SAPS PF04499.15 CDI86528.1 - 1.1 7.9 11.0 1.5 7.6 11.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SIT PF15330.6 CDI86528.1 - 1.7 9.1 15.0 0.12 12.8 3.5 2.5 2 1 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT baeRF_family10 PF18854.1 CDI86528.1 - 1.8 8.8 24.3 1.1 9.4 11.1 2.1 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 DUF1387 PF07139.11 CDI86528.1 - 2.2 7.9 16.2 2.7 7.6 16.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF5384 PF17358.2 CDI86528.1 - 2.3 8.3 35.8 0.13 12.3 7.7 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5384) Ctr PF04145.15 CDI86528.1 - 2.3 8.8 13.4 86 3.7 13.4 2.1 1 1 0 1 1 1 0 Ctr copper transporter family SID-1_RNA_chan PF13965.6 CDI86528.1 - 2.4 6.5 8.1 0.27 9.6 0.1 2.0 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 DUF3245 PF11595.8 CDI86528.1 - 3.1 8.3 19.8 2.1 8.8 9.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) DUF5327 PF17261.2 CDI86528.1 - 3.3 8.5 16.5 6.1 7.6 6.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5327) V_ATPase_I PF01496.19 CDI86528.1 - 3.3 5.5 18.5 3.7e+02 -1.3 18.5 2.0 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Hid1 PF12722.7 CDI86528.1 - 4.6 5.2 16.2 5.6 5.0 16.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CLN3 PF02487.17 CDI86528.1 - 5 6.1 14.3 0.32 10.0 0.5 2.0 1 1 1 2 2 2 0 CLN3 protein Herpes_UL17 PF04559.12 CDI86528.1 - 5.1 5.8 18.2 0.35 9.6 2.3 2.0 1 1 1 2 2 2 0 Herpesvirus UL17 protein SRP-alpha_N PF04086.13 CDI86528.1 - 5.4 6.8 18.3 7.1 6.5 18.3 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TMEM51 PF15345.6 CDI86528.1 - 5.5 6.7 22.2 3.8 7.3 4.2 2.2 1 1 1 2 2 2 0 Transmembrane protein 51 PTPRCAP PF15713.5 CDI86528.1 - 6.1 7.1 28.5 7 6.9 11.3 2.1 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated GREB1 PF15782.5 CDI86528.1 - 6.5 3.7 19.2 8.2 3.4 19.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF3807 PF12720.7 CDI86528.1 - 7.2 6.8 24.4 5.3 7.3 8.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) FxsA PF04186.13 CDI86528.1 - 7.3 6.8 9.7 1.4 9.1 1.7 2.3 2 0 0 2 2 2 0 FxsA cytoplasmic membrane protein rRNA_processing PF08524.11 CDI86528.1 - 9.4 6.2 26.7 1e+02 2.9 25.9 2.0 1 1 0 1 1 1 0 rRNA processing BAF1_ABF1 PF04684.13 CDI86529.1 - 0.0057 15.8 23.0 0.0084 15.2 23.0 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor RAP1 PF07218.11 CDI86529.1 - 0.0066 14.8 6.1 0.0062 14.9 6.1 1.1 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) MPM1 PF17234.2 CDI86529.1 - 0.23 11.7 24.3 1.5 9.1 15.7 2.3 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF4770 PF15994.5 CDI86529.1 - 0.53 10.5 23.3 0.13 12.4 12.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Macoilin PF09726.9 CDI86529.1 - 0.56 8.7 32.1 0.87 8.1 32.1 1.2 1 0 0 1 1 1 0 Macoilin family OAD_gamma PF04277.13 CDI86529.1 - 0.91 10.2 11.9 3.9 8.1 2.4 3.2 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain FAM76 PF16046.5 CDI86529.1 - 1 8.6 20.6 0.56 9.5 13.9 2.1 2 0 0 2 2 2 0 FAM76 protein Plasmodium_Vir PF05795.11 CDI86529.1 - 1.4 8.2 19.3 0.18 11.2 13.6 1.9 2 0 0 2 2 2 0 Plasmodium vivax Vir protein LpxB PF02684.15 CDI86529.1 - 3.6 6.3 13.4 0.26 10.1 4.9 2.1 2 0 0 2 2 2 0 Lipid-A-disaccharide synthetase LAP1C PF05609.12 CDI86529.1 - 4.2 6.3 29.0 5.5 6.0 29.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Hamartin PF04388.12 CDI86529.1 - 5.5 5.5 26.2 9.2 4.8 26.2 1.3 1 0 0 1 1 1 0 Hamartin protein RskA PF10099.9 CDI86530.1 - 0.0053 17.1 11.0 0.0053 17.1 11.0 8.0 2 2 3 5 5 5 2 Anti-sigma-K factor rskA DUF5134 PF17197.4 CDI86530.1 - 0.06 13.3 0.4 0.06 13.3 0.4 4.4 3 1 0 3 3 3 0 Domain of unknown function (DUF5134) Sulf_transp PF04143.14 CDI86530.1 - 1.8 8.0 13.1 0.96 8.9 1.0 2.6 2 0 0 2 2 2 0 Sulphur transport DUF572 PF04502.13 CDI86531.1 - 1.8 8.1 23.1 2.1 7.9 23.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) TAF1D PF15333.6 CDI86531.1 - 2.2 8.0 20.8 2.6 7.7 20.8 1.0 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D PRAS PF15798.5 CDI86531.1 - 3.5 8.2 9.0 5.3 7.6 9.0 1.3 1 0 0 1 1 1 0 Proline-rich AKT1 substrate 1 DUF913 PF06025.12 CDI86531.1 - 4.1 6.3 16.1 4.5 6.1 16.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Neuraminidase PF18413.1 CDI86531.1 - 4.5 6.9 20.8 5.5 6.6 20.8 1.1 1 0 0 1 1 1 0 Neuraminidase-like domain DUF4050 PF13259.6 CDI86531.1 - 6.6 7.0 22.0 8.3 6.7 22.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) RNase_P_p30 PF01876.16 CDI86531.1 - 7.1 6.0 13.1 12 5.2 13.1 1.4 1 1 0 1 1 1 0 RNase P subunit p30 DUF1117 PF06547.12 CDI86531.1 - 7.4 7.2 7.7 11 6.5 7.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1117) Presenilin PF01080.17 CDI86531.1 - 7.7 5.2 30.3 8 5.1 30.3 1.0 1 0 0 1 1 1 0 Presenilin PIP5K PF01504.18 CDI86531.1 - 9 5.4 19.5 12 5.0 19.5 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Sin_N PF04801.13 CDI86531.1 - 9.2 5.4 39.3 11 5.1 39.3 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region MAT1 PF06391.13 CDI86532.1 - 2.6 7.8 47.0 1.9 8.3 10.7 2.1 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 CD20 PF04103.15 CDI86532.1 - 5.5 7.1 8.9 5.5 7.0 0.5 2.8 2 1 1 3 3 3 0 CD20-like family PMSI1 PF15322.6 CDI86533.1 - 0.0046 16.5 9.0 0.0052 16.3 9.0 1.0 1 0 0 1 1 1 1 Protein missing in infertile sperm 1, putative FmiP_Thoc5 PF09766.9 CDI86533.1 - 0.052 12.8 17.6 0.06 12.6 17.6 1.0 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 BAF1_ABF1 PF04684.13 CDI86533.1 - 0.062 12.3 15.3 0.069 12.2 15.3 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SelP_N PF04592.14 CDI86533.1 - 0.092 12.1 17.2 0.11 11.8 17.2 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Pex14_N PF04695.13 CDI86533.1 - 0.17 12.5 29.0 0.21 12.2 29.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SID-1_RNA_chan PF13965.6 CDI86533.1 - 0.25 9.7 5.0 0.26 9.7 5.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Lin-8 PF03353.15 CDI86533.1 - 0.29 10.7 19.3 0.32 10.5 19.3 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Baculo_PP31 PF05311.11 CDI86533.1 - 0.37 10.2 13.9 0.44 10.0 13.9 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Glt_symporter PF03616.14 CDI86533.1 - 0.37 9.4 3.0 0.39 9.3 3.0 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter TFIIA PF03153.13 CDI86533.1 - 0.41 10.6 41.1 0.47 10.4 41.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI86533.1 - 0.49 8.6 26.9 0.53 8.5 26.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1744 PF08490.12 CDI86533.1 - 0.53 8.8 10.1 1.2 7.6 10.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1744) CCSAP PF15748.5 CDI86533.1 - 0.56 10.3 19.6 0.61 10.2 19.6 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4569 PF15133.6 CDI86533.1 - 0.62 9.7 18.2 0.75 9.5 18.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Connexin PF00029.19 CDI86533.1 - 0.63 9.8 12.0 0.68 9.7 12.0 1.1 1 0 0 1 1 1 0 Connexin Peptidase_S15 PF02129.18 CDI86533.1 - 0.71 9.4 11.0 0.83 9.2 11.0 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Endostatin PF06482.11 CDI86533.1 - 0.74 9.2 14.9 0.78 9.1 14.9 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Presenilin PF01080.17 CDI86533.1 - 0.77 8.4 22.3 0.87 8.3 22.3 1.0 1 0 0 1 1 1 0 Presenilin MAJIN PF15077.6 CDI86533.1 - 0.87 9.3 12.5 0.86 9.3 12.5 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein Eapp_C PF10238.9 CDI86533.1 - 0.88 9.6 16.3 1.3 9.1 16.3 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein CPSF100_C PF13299.6 CDI86533.1 - 1.1 9.4 15.2 1.6 8.9 15.2 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal eIF-3_zeta PF05091.12 CDI86533.1 - 1.2 8.0 21.7 1.3 7.9 21.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Velvet PF11754.8 CDI86533.1 - 1.2 9.0 17.2 1.3 8.9 17.2 1.0 1 0 0 1 1 1 0 Velvet factor FAM60A PF15396.6 CDI86533.1 - 1.3 9.0 12.8 1.4 8.9 12.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A YABBY PF04690.13 CDI86533.1 - 1.4 9.5 10.2 1.7 9.2 10.2 1.3 1 0 0 1 1 1 0 YABBY protein Peptidase_U57 PF05582.12 CDI86533.1 - 1.4 8.1 10.0 1.6 8.0 10.0 1.1 1 0 0 1 1 1 0 YabG peptidase U57 DUF3807 PF12720.7 CDI86533.1 - 1.5 9.1 24.8 1.8 8.8 24.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Gastrin PF00918.17 CDI86533.1 - 1.5 9.8 15.0 1.9 9.5 15.0 1.2 1 0 0 1 1 1 0 Gastrin/cholecystokinin family SpoIIP PF07454.11 CDI86533.1 - 1.6 8.2 17.2 1.8 8.0 17.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Serinc PF03348.15 CDI86533.1 - 1.6 7.6 10.8 1.8 7.4 10.8 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) RR_TM4-6 PF06459.12 CDI86533.1 - 1.6 8.5 19.4 1.8 8.3 19.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 THOC2_N PF16134.5 CDI86533.1 - 1.7 7.1 14.3 2.1 6.9 14.3 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus BORG_CEP PF14957.6 CDI86533.1 - 1.9 9.7 10.1 2.2 9.5 10.1 1.2 1 0 0 1 1 1 0 Cdc42 effector Rtf2 PF04641.12 CDI86533.1 - 1.9 7.8 17.5 2.2 7.6 17.5 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger TERB2 PF15101.6 CDI86533.1 - 2 8.5 21.0 2.5 8.1 21.0 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 IHABP4_N PF16174.5 CDI86533.1 - 2 9.0 25.2 2.7 8.6 25.2 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal VIR_N PF15912.5 CDI86533.1 - 2.2 7.8 9.4 2.4 7.7 9.4 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DUF5521 PF17659.1 CDI86533.1 - 2.2 6.0 11.6 2.6 5.8 11.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5521) DUF3523 PF12037.8 CDI86533.1 - 2.3 7.5 29.1 2.4 7.5 29.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) CDC45 PF02724.14 CDI86533.1 - 2.5 6.3 15.2 2.5 6.3 15.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Ctr PF04145.15 CDI86533.1 - 2.7 8.6 8.6 3.4 8.3 8.6 1.3 1 0 0 1 1 1 0 Ctr copper transporter family SLC12 PF03522.15 CDI86533.1 - 2.7 6.9 17.3 3 6.8 17.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Band_3_cyto PF07565.13 CDI86533.1 - 2.9 7.6 19.4 3.6 7.3 19.4 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain NEMP PF10225.9 CDI86533.1 - 3.1 7.4 5.8 3.6 7.2 5.8 1.1 1 0 0 1 1 1 0 NEMP family DUF1980 PF09323.10 CDI86533.1 - 3.1 7.7 15.4 4 7.3 15.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Membralin PF09746.9 CDI86533.1 - 3.2 6.7 9.5 3.6 6.5 9.5 1.0 1 0 0 1 1 1 0 Tumour-associated protein DDHD PF02862.17 CDI86533.1 - 3.4 7.8 17.4 3.9 7.6 17.4 1.1 1 0 0 1 1 1 0 DDHD domain NPR3 PF03666.13 CDI86533.1 - 3.6 6.3 15.0 3.7 6.2 15.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pannexin_like PF12534.8 CDI86533.1 - 3.6 6.6 12.6 3.8 6.5 12.6 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF913 PF06025.12 CDI86533.1 - 3.7 6.4 11.8 4.1 6.3 11.8 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hydin_ADK PF17213.3 CDI86533.1 - 3.7 7.8 19.1 4.2 7.6 19.1 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain VIT1 PF01988.19 CDI86533.1 - 3.7 7.3 8.8 5 6.9 8.8 1.2 1 0 0 1 1 1 0 VIT family DUF4746 PF15928.5 CDI86533.1 - 3.8 6.8 11.4 4.9 6.5 11.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) R_equi_Vir PF05526.11 CDI86533.1 - 4 7.3 12.6 5.1 6.9 12.6 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Folliculin PF11704.8 CDI86533.1 - 4.1 7.3 13.8 5.5 6.8 13.8 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Gti1_Pac2 PF09729.9 CDI86533.1 - 4.2 7.4 13.8 5.1 7.2 13.8 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family MRI PF15325.6 CDI86533.1 - 4.4 8.4 9.1 5.9 8.0 9.1 1.2 1 0 0 1 1 1 0 Modulator of retrovirus infection ALMT PF11744.8 CDI86533.1 - 5 5.8 12.3 5.3 5.8 12.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter HNOBA PF07701.14 CDI86533.1 - 5.4 6.4 13.9 6.1 6.2 13.9 1.2 1 0 0 1 1 1 0 Heme NO binding associated Dicty_REP PF05086.12 CDI86533.1 - 5.5 4.8 14.7 5.6 4.8 14.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Neur_chan_memb PF02932.16 CDI86533.1 - 5.7 6.9 13.7 6.5 6.7 13.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2232 PF09991.9 CDI86533.1 - 5.9 6.0 4.3 7 5.7 4.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Ureide_permease PF07168.11 CDI86533.1 - 6 5.5 7.9 6.6 5.4 7.9 1.2 1 0 0 1 1 1 0 Ureide permease Ndc1_Nup PF09531.10 CDI86533.1 - 6.1 5.4 15.1 6.3 5.4 15.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4228 PF14009.6 CDI86533.1 - 6.5 7.1 12.7 7.7 6.9 12.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Peptidase_S49_N PF08496.10 CDI86533.1 - 6.7 6.8 14.1 9.4 6.3 14.1 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RPN2_C PF18004.1 CDI86533.1 - 6.8 6.6 18.6 8.4 6.3 18.6 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Hid1 PF12722.7 CDI86533.1 - 7.3 4.6 18.0 7.6 4.5 18.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Raftlin PF15250.6 CDI86533.1 - 7.3 5.2 17.8 8.4 5.0 17.8 1.0 1 0 0 1 1 1 0 Raftlin DUF2828 PF11443.8 CDI86533.1 - 8 4.4 18.0 8.8 4.3 18.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Zip PF02535.22 CDI86533.1 - 8.9 5.4 12.2 11 5.2 12.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CLN3 PF02487.17 CDI86533.1 - 8.9 5.2 12.9 8.9 5.2 12.9 1.1 1 0 0 1 1 1 0 CLN3 protein Folate_carrier PF01770.18 CDI86533.1 - 8.9 4.9 8.9 9.5 4.8 8.9 1.1 1 0 0 1 1 1 0 Reduced folate carrier V_ATPase_I PF01496.19 CDI86533.1 - 9.2 4.0 17.7 9.6 4.0 17.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 CDI86534.1 - 0.007 16.2 18.4 0.0081 16.0 18.4 1.0 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 SID-1_RNA_chan PF13965.6 CDI86534.1 - 0.015 13.7 1.4 0.018 13.5 1.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI86534.1 - 0.017 13.1 6.7 0.017 13.1 6.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Velvet PF11754.8 CDI86534.1 - 0.032 14.2 12.2 0.045 13.7 12.2 1.3 1 0 0 1 1 1 0 Velvet factor DUF2052 PF09747.9 CDI86534.1 - 0.12 12.5 18.6 0.14 12.3 18.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Noggin PF05806.12 CDI86534.1 - 0.2 11.5 7.7 0.28 11.1 7.7 1.2 1 0 0 1 1 1 0 Noggin NARP1 PF12569.8 CDI86534.1 - 0.22 10.4 13.5 0.24 10.2 13.5 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDC45 PF02724.14 CDI86534.1 - 0.39 9.0 17.5 0.46 8.7 17.5 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.6 CDI86534.1 - 0.39 10.3 18.3 0.43 10.2 18.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PTPRCAP PF15713.5 CDI86534.1 - 0.53 10.6 23.8 0.76 10.0 23.8 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated PAT1 PF09770.9 CDI86534.1 - 0.64 8.2 30.7 0.69 8.1 30.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ndc1_Nup PF09531.10 CDI86534.1 - 0.73 8.4 15.4 0.82 8.3 15.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Endostatin PF06482.11 CDI86534.1 - 0.74 9.2 16.9 0.86 9.0 16.9 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF913 PF06025.12 CDI86534.1 - 0.75 8.7 9.4 0.83 8.6 9.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4407 PF14362.6 CDI86534.1 - 0.8 9.0 15.7 1.3 8.3 15.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SprA-related PF12118.8 CDI86534.1 - 0.95 8.5 32.5 1.2 8.3 32.5 1.1 1 0 0 1 1 1 0 SprA-related family CSG2 PF16965.5 CDI86534.1 - 0.96 8.3 4.4 1 8.2 4.4 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator MMR1 PF08505.10 CDI86534.1 - 1 9.6 24.6 1.3 9.2 24.6 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Lin-8 PF03353.15 CDI86534.1 - 1.1 8.7 24.3 1.3 8.5 24.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Neur_chan_memb PF02932.16 CDI86534.1 - 1.1 9.2 15.1 1.3 9.0 15.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 CDI86534.1 - 1.2 8.0 17.5 1.4 7.9 17.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 CDI86534.1 - 1.7 8.6 12.4 2 8.4 12.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF2126 PF09899.9 CDI86534.1 - 1.8 6.6 9.7 2 6.4 9.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CCSAP PF15748.5 CDI86534.1 - 1.9 8.6 23.0 2.3 8.3 23.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Bud13 PF09736.9 CDI86534.1 - 2.1 8.7 21.6 2.9 8.3 21.6 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Presenilin PF01080.17 CDI86534.1 - 2.2 6.9 23.4 2.9 6.6 23.4 1.1 1 0 0 1 1 1 0 Presenilin Gti1_Pac2 PF09729.9 CDI86534.1 - 2.9 8.0 14.8 3.7 7.6 14.8 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Serinc PF03348.15 CDI86534.1 - 3.4 6.5 5.6 4 6.3 5.6 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Paf1 PF03985.13 CDI86534.1 - 3.7 6.5 22.5 4.4 6.2 22.5 1.1 1 0 0 1 1 1 0 Paf1 CDK5_activator PF03261.15 CDI86534.1 - 3.7 7.0 16.2 4.4 6.8 16.2 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein eIF-3_zeta PF05091.12 CDI86534.1 - 4 6.3 18.8 4.8 6.0 18.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CLN3 PF02487.17 CDI86534.1 - 4.1 6.4 13.1 5.4 5.9 13.1 1.2 1 0 0 1 1 1 0 CLN3 protein Tim54 PF11711.8 CDI86534.1 - 4.1 6.1 17.8 5.1 5.8 17.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 ALMT PF11744.8 CDI86534.1 - 5 5.8 14.5 5.9 5.6 14.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Paramyxo_ncap PF00973.19 CDI86534.1 - 5.4 5.8 13.2 6 5.7 13.2 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein rRNA_processing PF08524.11 CDI86534.1 - 6.3 6.8 34.9 8.5 6.4 34.9 1.1 1 0 0 1 1 1 0 rRNA processing Dynactin_p62 PF05502.13 CDI86534.1 - 6.8 5.3 17.0 8.4 5.0 17.0 1.0 1 0 0 1 1 1 0 Dynactin p62 family DUF2828 PF11443.8 CDI86534.1 - 7 4.6 15.2 8.3 4.4 15.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) GET2 PF08690.10 CDI86534.1 - 9.5 5.8 20.2 12 5.5 20.2 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 RskA PF10099.9 CDI86535.1 - 1.3e-06 28.9 12.6 0.0024 18.2 0.0 9.8 5 3 1 8 8 8 2 Anti-sigma-K factor rskA EOS1 PF12326.8 CDI86535.1 - 0.016 15.1 0.4 0.016 15.1 0.4 7.3 5 1 0 5 5 5 0 N-glycosylation protein SUIM_assoc PF16619.5 CDI86535.1 - 0.027 14.5 0.1 0.027 14.5 0.1 12.5 8 2 1 9 9 9 0 Unstructured region C-term to UIM in Ataxin3 NAM-associated PF14303.6 CDI86535.1 - 2.2 8.9 0.0 2.2 8.9 0.0 10.9 8 4 1 9 9 9 0 No apical meristem-associated C-terminal domain CAF1 PF04857.20 CDI86536.1 - 1.2e-44 152.8 25.8 1.2e-43 149.5 24.1 2.4 1 1 0 1 1 1 1 CAF1 family ribonuclease SWIRM-assoc_2 PF16496.5 CDI86536.1 - 6.9 5.4 27.2 14 4.4 27.2 1.5 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Ribosomal_60s PF00428.19 CDI86538.1 - 0.78 10.4 10.7 1.2 9.8 10.7 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein MRI PF15325.6 CDI86538.1 - 5.2 8.2 12.7 8 7.6 12.7 1.3 1 0 0 1 1 1 0 Modulator of retrovirus infection BAF1_ABF1 PF04684.13 CDI86538.1 - 9.7 5.1 28.6 13 4.7 28.6 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF1010 PF06231.11 CDI86539.1 - 9.5 6.8 8.3 21 5.7 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1010) SID-1_RNA_chan PF13965.6 CDI86540.1 - 6.9e-05 21.5 7.8 7.9e-05 21.3 7.8 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 SARAF PF06682.12 CDI86540.1 - 7.6e-05 22.5 9.8 8.7e-05 22.3 9.8 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis V_ATPase_I PF01496.19 CDI86540.1 - 0.00012 20.2 21.5 0.00014 19.9 21.5 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF4834 PF16118.5 CDI86540.1 - 0.00015 22.6 26.8 0.032 15.2 26.8 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4834) TRAP_alpha PF03896.16 CDI86540.1 - 0.00016 21.0 6.3 0.00021 20.6 6.3 1.3 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit O-antigen_lig PF13425.6 CDI86540.1 - 0.00022 20.2 9.4 0.00025 20.0 9.4 1.0 1 0 0 1 1 1 1 O-antigen ligase like membrane protein Zip PF02535.22 CDI86540.1 - 0.00022 20.6 7.2 0.00025 20.4 7.2 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Ctr PF04145.15 CDI86540.1 - 0.00076 20.1 7.0 0.0011 19.6 7.0 1.3 1 0 0 1 1 1 1 Ctr copper transporter family CBP_BcsG PF11658.8 CDI86540.1 - 0.0011 17.5 12.3 0.0012 17.3 12.3 1.1 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG DUF4131 PF13567.6 CDI86540.1 - 0.0023 17.6 0.6 0.0029 17.3 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) Tmemb_9 PF05434.11 CDI86540.1 - 0.0033 17.3 22.1 0.0042 17.0 22.1 1.2 1 0 0 1 1 1 1 TMEM9 CLN3 PF02487.17 CDI86540.1 - 0.0036 16.4 14.3 0.004 16.2 14.3 1.1 1 0 0 1 1 1 1 CLN3 protein Neur_chan_memb PF02932.16 CDI86540.1 - 0.0046 17.1 14.4 0.0054 16.8 14.4 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region CRA PF06589.11 CDI86540.1 - 0.0055 16.8 6.0 0.0076 16.4 6.0 1.3 1 0 0 1 1 1 1 Circumsporozoite-related antigen (CRA) DUF5385 PF17359.2 CDI86540.1 - 0.006 16.2 3.3 0.006 16.2 3.3 2.2 1 1 1 2 2 1 1 Family of unknown function (DUF5385) FHIPEP PF00771.20 CDI86540.1 - 0.0088 14.6 14.7 0.011 14.2 14.7 1.2 1 0 0 1 1 1 1 FHIPEP family Pex24p PF06398.11 CDI86540.1 - 0.01 14.9 7.1 0.018 14.0 7.1 1.6 1 1 0 1 1 1 1 Integral peroxisomal membrane peroxin LYRIC PF15686.5 CDI86540.1 - 0.011 15.3 15.6 0.014 15.0 15.6 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family MMM1 PF10296.9 CDI86540.1 - 0.013 14.6 10.3 0.017 14.2 10.3 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Serinc PF03348.15 CDI86540.1 - 0.015 14.2 7.3 0.02 13.8 7.3 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) CSG2 PF16965.5 CDI86540.1 - 0.016 14.2 10.4 0.019 13.9 10.4 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Mem_trans PF03547.18 CDI86540.1 - 0.022 13.2 10.9 0.024 13.0 10.9 1.0 1 0 0 1 1 1 0 Membrane transport protein Choline_transpo PF04515.12 CDI86540.1 - 0.025 13.8 0.0 0.025 13.8 0.0 1.1 1 0 0 1 1 1 0 Plasma-membrane choline transporter tRNA_anti-like PF12869.7 CDI86540.1 - 0.029 14.0 8.6 0.011 15.3 5.3 1.7 1 1 1 2 2 2 0 tRNA_anti-like Ion_trans PF00520.31 CDI86540.1 - 0.034 13.4 0.0 0.034 13.4 0.0 1.1 1 0 0 1 1 1 0 Ion transport protein Wzy_C PF04932.15 CDI86540.1 - 0.038 13.6 0.0 0.048 13.3 0.0 1.2 1 0 0 1 1 1 0 O-Antigen ligase DUF2448 PF10476.9 CDI86540.1 - 0.044 13.7 6.8 0.056 13.3 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) O-ag_pol_Wzy PF14296.6 CDI86540.1 - 0.05 12.3 0.3 0.072 11.7 0.3 1.2 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy DUF3742 PF12553.8 CDI86540.1 - 0.088 12.9 4.3 0.24 11.5 4.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3742) CitMHS PF03600.16 CDI86540.1 - 0.096 11.9 0.0 0.096 11.9 0.0 1.1 1 0 0 1 1 1 0 Citrate transporter DUF898 PF05987.13 CDI86540.1 - 0.099 11.7 3.3 0.079 12.0 2.6 1.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Ni_hydr_CYTB PF01292.20 CDI86540.1 - 0.13 11.8 5.7 0.28 10.7 5.7 1.8 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 Sre PF03125.18 CDI86540.1 - 0.17 11.0 6.0 0.21 10.7 6.0 1.1 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor FAM176 PF14851.6 CDI86540.1 - 0.17 11.5 19.3 0.83 9.3 19.3 1.9 1 1 0 1 1 1 0 FAM176 family Herpes_LMP1 PF05297.11 CDI86540.1 - 0.22 10.7 1.8 0.25 10.5 1.8 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) NEMP PF10225.9 CDI86540.1 - 0.25 11.0 10.3 0.35 10.5 10.3 1.3 1 0 0 1 1 1 0 NEMP family MSP1a PF11670.8 CDI86540.1 - 0.3 10.3 5.6 0.12 11.7 3.5 1.4 1 1 0 1 1 1 0 Major surface protein 1a (MSP1a) G6B PF15096.6 CDI86540.1 - 0.31 10.8 6.5 0.38 10.5 6.5 1.1 1 0 0 1 1 1 0 G6B family DUF4330 PF14221.6 CDI86540.1 - 0.46 10.7 4.1 0.73 10.0 4.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4330) K_trans PF02705.16 CDI86540.1 - 0.49 8.8 8.0 0.65 8.4 8.0 1.2 1 0 0 1 1 1 0 K+ potassium transporter Tmp39 PF10271.9 CDI86540.1 - 0.57 9.1 8.5 0.65 8.9 8.5 1.1 1 0 0 1 1 1 0 Putative transmembrane protein DUF2828 PF11443.8 CDI86540.1 - 0.73 7.8 23.2 0.8 7.7 23.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) ABC_export PF16962.5 CDI86540.1 - 0.76 8.2 8.8 0.42 9.0 7.5 1.3 1 1 0 1 1 1 0 Putative ABC exporter MAPEG PF01124.18 CDI86540.1 - 0.79 9.6 8.8 2.6 8.0 8.8 2.0 1 1 0 1 1 1 0 MAPEG family DUF4446 PF14584.6 CDI86540.1 - 0.83 9.6 19.5 1.6 8.7 19.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) OAD_gamma PF04277.13 CDI86540.1 - 0.87 10.2 14.6 17 6.1 14.6 2.4 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Sulf_transp PF04143.14 CDI86540.1 - 0.96 8.9 4.2 1.1 8.7 4.2 1.4 1 1 0 1 1 1 0 Sulphur transport DHHC PF01529.20 CDI86540.1 - 0.97 9.5 3.9 0.9 9.6 3.0 1.6 1 1 0 1 1 1 0 DHHC palmitoyltransferase CreD PF06123.12 CDI86540.1 - 1.1 8.0 11.6 1.4 7.6 11.6 1.2 1 0 0 1 1 1 0 Inner membrane protein CreD Acatn PF13000.7 CDI86540.1 - 1.1 7.7 8.2 1.4 7.3 8.2 1.3 1 1 0 1 1 1 0 Acetyl-coenzyme A transporter 1 SIT PF15330.6 CDI86540.1 - 1.1 9.7 32.6 2 8.9 32.6 1.6 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT FliP PF00813.20 CDI86540.1 - 1.1 9.1 14.9 1.4 8.8 14.9 1.2 1 0 0 1 1 1 0 FliP family HCO3_cotransp PF00955.21 CDI86540.1 - 1.2 7.9 10.7 1.4 7.7 10.7 1.1 1 0 0 1 1 1 0 HCO3- transporter family HemX PF04375.14 CDI86540.1 - 1.2 8.3 40.0 1.5 8.0 40.0 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase NicO PF03824.16 CDI86540.1 - 1.2 8.4 10.1 2 7.7 10.1 1.4 1 1 0 1 1 1 0 High-affinity nickel-transport protein ABC2_membrane_2 PF12679.7 CDI86540.1 - 2.2 7.5 13.7 4.2 6.6 13.7 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein CobT PF06213.12 CDI86540.1 - 2.3 7.6 30.8 2.7 7.3 30.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Connexin PF00029.19 CDI86540.1 - 2.3 7.9 26.2 18 5.0 26.2 1.9 1 1 0 1 1 1 0 Connexin DUF2140 PF09911.9 CDI86540.1 - 2.4 7.7 21.2 15 5.1 21.2 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF3810 PF12725.7 CDI86540.1 - 2.5 7.4 8.4 3.1 7.0 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) DUF3357 PF11837.8 CDI86540.1 - 2.6 8.5 9.3 12 6.4 9.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) Tetraspanin PF00335.20 CDI86540.1 - 3.7 7.2 13.5 5 6.8 13.5 1.4 1 1 0 1 1 1 0 Tetraspanin family Folate_carrier PF01770.18 CDI86540.1 - 4 6.1 17.8 2.8 6.6 16.1 1.5 1 1 1 2 2 2 0 Reduced folate carrier Comm PF15957.5 CDI86540.1 - 4.1 7.8 11.5 25 5.3 11.5 1.9 1 1 0 1 1 1 0 Commissureless SLC12 PF03522.15 CDI86540.1 - 4.3 6.2 26.5 4.7 6.1 26.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF1345 PF07077.11 CDI86540.1 - 4.9 6.8 7.5 0.22 11.2 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) DUF2370 PF10176.9 CDI86540.1 - 5.7 6.5 14.8 6.9 6.2 14.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) VanZ PF04892.12 CDI86540.1 - 6 7.5 7.1 18 6.0 7.1 2.0 1 1 0 1 1 1 0 VanZ like family BORG_CEP PF14957.6 CDI86540.1 - 6.3 8.0 17.4 8 7.7 17.4 1.2 1 0 0 1 1 1 0 Cdc42 effector DUF3450 PF11932.8 CDI86540.1 - 6.3 6.0 38.3 7.5 5.8 38.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4228 PF14009.6 CDI86540.1 - 6.6 7.1 14.2 8.5 6.7 14.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Pex14_N PF04695.13 CDI86540.1 - 7.7 7.2 30.1 11 6.6 30.1 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region OATP PF03137.20 CDI86540.1 - 8.1 4.6 21.5 22 3.2 21.5 1.7 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family TRP PF06011.12 CDI86540.1 - 8.7 5.0 6.7 0.91 8.2 1.9 1.7 1 1 1 2 2 2 0 Transient receptor potential (TRP) ion channel Rtf2 PF04641.12 CDI86540.1 - 9.6 5.5 29.7 11 5.3 29.7 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger TssO PF17561.2 CDI86540.1 - 9.7 6.3 28.3 0.063 13.4 12.0 2.1 1 1 1 2 2 1 0 Type VI secretion system, TssO CD20 PF04103.15 CDI86541.1 - 0.0003 20.9 0.1 0.0003 20.9 0.1 3.0 2 1 0 2 2 2 1 CD20-like family GT87 PF09594.10 CDI86544.1 - 0.013 15.3 4.3 0.055 13.2 3.7 2.1 2 0 0 2 2 2 0 Glycosyltransferase family 87 Allexi_40kDa PF05549.11 CDI86546.1 - 3.9 6.9 14.6 4.5 6.7 14.6 1.0 1 0 0 1 1 1 0 Allexivirus 40kDa protein Pet20 PF08692.10 CDI86546.1 - 8 7.2 8.8 9.1 7.0 8.8 1.1 1 0 0 1 1 1 0 Mitochondrial protein Pet20 DUF5423 PF17461.2 CDI86548.1 - 0.00045 19.2 1.3 0.0005 19.0 1.3 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5423) Spt20 PF12090.8 CDI86548.1 - 0.0018 17.9 11.6 0.0019 17.8 11.6 1.2 1 0 0 1 1 1 1 Spt20 family ESM4 PF15952.5 CDI86548.1 - 0.0041 17.6 6.4 0.005 17.3 6.4 1.1 1 0 0 1 1 1 1 Enhancer of split M4 family Activator_LAG-3 PF11498.8 CDI86548.1 - 0.0046 16.0 15.0 0.0047 16.0 15.0 1.1 1 0 0 1 1 1 1 Transcriptional activator LAG-3 SARAF PF06682.12 CDI86548.1 - 0.013 15.2 10.9 0.015 15.0 10.9 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis TFIIA PF03153.13 CDI86548.1 - 0.018 15.1 14.7 0.019 14.9 14.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF572 PF04502.13 CDI86548.1 - 0.032 13.8 7.8 0.035 13.7 7.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) CDC27 PF09507.10 CDI86548.1 - 0.035 13.5 8.4 0.038 13.4 8.4 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Tau95_N PF17682.1 CDI86548.1 - 0.048 13.9 1.6 0.054 13.7 1.6 1.2 1 0 0 1 1 1 0 Tau95 Triple barrel domain Herpes_UL87 PF03043.14 CDI86548.1 - 0.084 11.3 1.1 0.1 11.1 1.1 1.0 1 0 0 1 1 1 0 Herpesvirus UL87 family BSP_II PF05432.11 CDI86548.1 - 0.088 12.5 5.9 0.1 12.3 5.9 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF5527 PF17665.1 CDI86548.1 - 0.089 12.3 1.5 0.11 12.0 1.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5527) PA26 PF04636.13 CDI86548.1 - 0.12 11.3 3.1 0.12 11.2 3.1 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) FAM199X PF15814.5 CDI86548.1 - 0.12 11.4 6.8 0.16 11.0 6.8 1.1 1 0 0 1 1 1 0 Protein family FAM199X RR_TM4-6 PF06459.12 CDI86548.1 - 0.2 11.5 5.8 0.21 11.4 5.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 CDI86548.1 - 0.21 10.5 9.1 0.21 10.5 9.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM176 PF14851.6 CDI86548.1 - 0.22 11.2 2.8 0.3 10.7 2.8 1.2 1 0 0 1 1 1 0 FAM176 family Rpp20 PF12328.8 CDI86548.1 - 0.24 11.4 9.5 0.35 10.8 9.5 1.2 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P TERB2 PF15101.6 CDI86548.1 - 0.29 11.2 5.3 0.34 10.9 5.3 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 PRTP PF01366.18 CDI86548.1 - 0.31 9.0 6.3 0.35 8.9 6.3 1.0 1 0 0 1 1 1 0 Herpesvirus processing and transport protein FTO_NTD PF12933.7 CDI86548.1 - 0.34 10.1 7.5 0.43 9.8 7.5 1.1 1 0 0 1 1 1 0 FTO catalytic domain DUF4834 PF16118.5 CDI86548.1 - 0.41 11.7 9.1 0.75 10.8 9.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4366 PF14283.6 CDI86548.1 - 0.41 10.7 4.8 0.59 10.2 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DDHD PF02862.17 CDI86548.1 - 0.46 10.6 5.9 0.49 10.5 5.9 1.1 1 0 0 1 1 1 0 DDHD domain Suf PF05843.14 CDI86548.1 - 0.48 10.3 7.2 0.5 10.3 7.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 CDI86548.1 - 0.63 10.1 2.7 0.63 10.1 2.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_S49_N PF08496.10 CDI86548.1 - 0.67 10.0 8.3 0.87 9.6 8.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Peptidase_U57 PF05582.12 CDI86548.1 - 0.79 8.9 5.1 0.95 8.7 5.1 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Coilin_N PF15862.5 CDI86548.1 - 0.92 9.3 10.1 1.2 9.0 10.1 1.2 1 0 0 1 1 1 0 Coilin N-terminus Serinc PF03348.15 CDI86548.1 - 0.94 8.3 2.4 1 8.2 2.4 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ndc1_Nup PF09531.10 CDI86548.1 - 1 8.0 6.4 1 7.9 6.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF2722 PF10846.8 CDI86548.1 - 1.2 8.0 17.5 1.7 7.5 17.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Connexin PF00029.19 CDI86548.1 - 1.4 8.6 3.8 1.5 8.5 3.8 1.1 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 CDI86548.1 - 1.5 6.6 5.3 1.6 6.6 5.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 CDI86548.1 - 1.6 7.4 9.2 1.7 7.3 9.2 1.0 1 0 0 1 1 1 0 Presenilin CNDH2_M PF16869.5 CDI86548.1 - 2 9.1 6.9 2.1 9.0 6.4 1.3 1 1 0 1 1 1 0 PF16858 DUF4407 PF14362.6 CDI86548.1 - 2 7.7 18.3 2.3 7.5 18.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NARP1 PF12569.8 CDI86548.1 - 2.6 6.9 11.4 2.8 6.7 11.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Sec62 PF03839.16 CDI86548.1 - 2.6 7.5 6.6 3.4 7.1 6.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 UPF0560 PF10577.9 CDI86548.1 - 2.7 6.4 8.6 3 6.2 8.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Plasmodium_Vir PF05795.11 CDI86548.1 - 2.7 7.3 6.5 2.9 7.2 6.5 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Shadoo PF14999.6 CDI86548.1 - 2.9 8.0 26.1 0.61 10.2 9.1 2.3 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective NPR3 PF03666.13 CDI86548.1 - 3.1 6.5 7.6 3.6 6.3 7.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF1682 PF07946.14 CDI86548.1 - 3.6 6.7 12.6 4.6 6.3 12.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) EphA2_TM PF14575.6 CDI86548.1 - 4.8 8.1 5.7 8.8 7.3 5.7 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MCR_alpha PF02249.17 CDI86548.1 - 7.3 7.0 10.0 18 5.8 0.4 2.2 2 0 0 2 2 2 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain DUF2076 PF09849.9 CDI86548.1 - 9.3 6.2 33.3 13 5.8 32.5 1.6 1 1 1 2 2 1 0 Uncharacterized protein conserved in bacteria (DUF2076) RskA PF10099.9 CDI86549.1 - 0.0026 18.1 5.9 0.0035 17.7 5.9 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Peptidase_M20 PF01546.28 CDI86549.1 - 0.05 13.3 0.4 0.062 13.0 0.4 1.2 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 CENP-B_dimeris PF09026.10 CDI86549.1 - 0.23 11.8 10.3 0.4 11.1 10.3 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RXT2_N PF08595.11 CDI86549.1 - 0.31 11.1 8.8 0.045 13.8 3.0 2.0 2 0 0 2 2 2 0 RXT2-like, N-terminal Sigma70_ner PF04546.13 CDI86549.1 - 0.83 9.5 13.3 0.82 9.5 12.3 1.4 1 1 0 1 1 1 0 Sigma-70, non-essential region PP1c_bdg PF10488.9 CDI86549.1 - 1.3 8.4 9.6 0.39 10.2 6.6 1.6 1 1 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region TMEM247 PF15444.6 CDI86549.1 - 6.7 6.7 11.5 7.9 6.5 11.5 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 Methyltr_RsmB-F PF01189.17 CDI86550.1 - 1.5e-05 24.8 2.5 1.5e-05 24.8 2.5 1.6 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F PSK PF06404.12 CDI86550.1 - 0.21 12.6 3.8 0.79 10.8 3.8 2.0 1 0 0 1 1 1 0 Phytosulfokine precursor protein (PSK) Peptidase_C58 PF03543.14 CDI86550.1 - 1.4 8.6 10.4 2.4 7.8 10.4 1.3 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen Methyltransf_16 PF10294.9 CDI86555.1 - 0.00016 21.4 0.0 0.00029 20.6 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase zf-NADH-PPase PF09297.11 CDI86555.1 - 0.21 11.3 1.8 1.1 9.0 1.8 2.3 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain RRM_1 PF00076.22 CDI86556.1 - 3.1e-07 30.1 0.0 4.9e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDI86556.1 - 0.017 14.9 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Lactamase_B_2 PF12706.7 CDI86557.1 - 3.7e-08 33.1 1.5 3.7e-05 23.3 0.4 3.5 3 1 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDI86557.1 - 0.00022 21.3 0.1 0.0026 17.8 0.1 2.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF1770 PF08589.10 CDI86558.1 - 0.2 12.6 0.2 0.2 12.6 0.2 3.3 3 0 0 3 3 3 0 Fungal protein of unknown function (DUF1770) Dehydrin PF00257.19 CDI86558.1 - 3.5 8.2 9.0 1.2 9.6 0.5 2.7 2 0 0 2 2 2 0 Dehydrin RNA_pol_Rpb2_6 PF00562.28 CDI86560.1 - 6.9e-106 354.6 0.0 1e-105 354.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CDI86560.1 - 1e-25 90.5 0.0 1.6e-25 89.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 CDI86560.1 - 1.4e-19 70.3 0.0 2.6e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 CDI86560.1 - 9e-15 54.6 0.0 2.6e-14 53.1 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 TFIIA PF03153.13 CDI86562.1 - 0.039 13.9 65.7 0.043 13.8 65.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_23 PF13476.6 CDI86562.1 - 0.067 13.7 29.1 0.076 13.5 29.1 1.1 1 0 0 1 1 1 0 AAA domain DUF1682 PF07946.14 CDI86562.1 - 0.46 9.6 16.2 0.54 9.4 16.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) eIF-3_zeta PF05091.12 CDI86562.1 - 1.5 7.7 31.5 2.5 7.0 31.5 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SMYLE_N PF18615.1 CDI86562.1 - 1.6 8.2 35.3 1.8 8.1 35.3 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain RAP1 PF07218.11 CDI86562.1 - 2.4 6.4 20.2 2.9 6.1 20.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PalH PF08733.10 CDI86562.1 - 4.5 6.2 13.5 5.5 5.9 13.5 1.1 1 0 0 1 1 1 0 PalH/RIM21 SprA-related PF12118.8 CDI86562.1 - 7.4 5.6 65.6 14 4.7 65.4 1.5 1 1 0 1 1 1 0 SprA-related family PPP4R2 PF09184.11 CDI86562.1 - 9.1 5.8 35.2 11 5.5 35.2 1.0 1 0 0 1 1 1 0 PPP4R2 Tau95_N PF17682.1 CDI86563.1 - 0.11 12.8 6.6 0.11 12.6 6.6 1.0 1 0 0 1 1 1 0 Tau95 Triple barrel domain Spt20 PF12090.8 CDI86563.1 - 0.11 12.1 31.2 0.12 12.0 31.2 1.1 1 0 0 1 1 1 0 Spt20 family TFB6 PF17110.5 CDI86563.1 - 0.12 12.1 10.4 0.14 11.9 10.4 1.0 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH GRP PF07172.11 CDI86563.1 - 0.14 12.9 2.7 0.17 12.6 2.7 1.2 1 0 0 1 1 1 0 Glycine rich protein family Usp PF00582.26 CDI86563.1 - 0.18 12.3 4.9 0.2 12.2 4.9 1.1 1 0 0 1 1 1 0 Universal stress protein family DUF5327 PF17261.2 CDI86563.1 - 0.19 12.5 17.3 0.22 12.3 17.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5327) AFT PF08731.11 CDI86563.1 - 0.29 11.5 5.0 0.35 11.3 5.0 1.0 1 0 0 1 1 1 0 Transcription factor AFT FAM176 PF14851.6 CDI86563.1 - 0.5 10.0 7.8 0.57 9.8 7.8 1.1 1 0 0 1 1 1 0 FAM176 family RED_N PF07808.13 CDI86563.1 - 0.9 9.1 17.2 1 8.9 17.2 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region Afi1 PF07792.12 CDI86563.1 - 0.93 10.0 12.1 0.97 9.9 12.1 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking UPF0239 PF06783.11 CDI86563.1 - 1 9.6 7.4 1.3 9.2 7.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) CNDH2_C PF16858.5 CDI86563.1 - 1.1 9.1 16.1 1.1 9.1 16.1 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Activator_LAG-3 PF11498.8 CDI86563.1 - 1.3 8.0 39.8 1.3 8.0 39.8 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF2722 PF10846.8 CDI86563.1 - 1.5 7.7 26.8 1.5 7.7 26.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI86563.1 - 1.7 9.3 16.0 1.7 9.3 16.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region AIF_C PF14721.6 CDI86563.1 - 1.7 9.0 10.9 2 8.8 10.9 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TFIIA PF03153.13 CDI86563.1 - 2.6 8.0 29.5 2.4 8.1 29.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Connexin PF00029.19 CDI86563.1 - 2.7 7.7 10.3 2.9 7.6 10.3 1.0 1 0 0 1 1 1 0 Connexin TMEM51 PF15345.6 CDI86563.1 - 2.7 7.8 14.4 3.2 7.5 14.4 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 eIF-3_zeta PF05091.12 CDI86563.1 - 2.9 6.8 16.9 3.1 6.7 16.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TERB2 PF15101.6 CDI86563.1 - 3.1 7.8 17.9 3.2 7.7 17.9 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Paf1 PF03985.13 CDI86563.1 - 3.2 6.7 17.7 3.6 6.5 17.7 1.0 1 0 0 1 1 1 0 Paf1 CobT PF06213.12 CDI86563.1 - 3.2 7.1 20.4 3.1 7.1 20.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 CDI86563.1 - 3.3 6.4 14.2 3.4 6.3 14.2 1.0 1 0 0 1 1 1 0 Presenilin TPP_enzyme_N PF02776.18 CDI86563.1 - 3.3 7.3 7.6 4.5 6.9 7.6 1.3 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain SpoIIP PF07454.11 CDI86563.1 - 3.8 6.9 14.8 4.1 6.8 14.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) V_ATPase_I PF01496.19 CDI86563.1 - 3.8 5.3 13.6 3.8 5.3 13.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Conotoxin PF02950.17 CDI86563.1 - 3.9 8.6 9.9 7.4 7.7 9.9 1.5 1 1 0 1 1 1 0 Conotoxin Peroxin-13_N PF04088.13 CDI86563.1 - 4.4 7.6 8.1 4.8 7.5 8.1 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Endonuc_Holl PF10107.9 CDI86563.1 - 4.8 7.0 10.8 5.4 6.8 10.8 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase FAM150 PF15129.6 CDI86563.1 - 5.6 7.1 14.1 6.8 6.9 14.1 1.1 1 0 0 1 1 1 0 FAM150 family Band_3_cyto PF07565.13 CDI86563.1 - 6.5 6.5 11.5 6.8 6.4 11.5 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Neur_chan_memb PF02932.16 CDI86563.1 - 6.7 6.7 9.0 7.3 6.6 9.0 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4746 PF15928.5 CDI86563.1 - 7.3 5.9 12.6 7 6.0 12.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CLN3 PF02487.17 CDI86563.1 - 7.7 5.5 9.7 8.2 5.4 9.7 1.0 1 0 0 1 1 1 0 CLN3 protein Saw1 PF11561.8 CDI86563.1 - 7.7 6.0 11.8 7.9 5.9 11.8 1.0 1 0 0 1 1 1 0 Single strand annealing-weakened 1 DUF3464 PF11947.8 CDI86563.1 - 7.8 6.2 12.4 8.4 6.1 12.4 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 YhfC PF10086.9 CDI86563.1 - 8 5.8 6.8 8.9 5.6 6.8 1.1 1 0 0 1 1 1 0 YhfC intramembrane metalloprotease DDHD PF02862.17 CDI86563.1 - 8.6 6.4 11.6 8.6 6.5 11.6 1.0 1 0 0 1 1 1 0 DDHD domain SID-1_RNA_chan PF13965.6 CDI86563.1 - 9.7 4.5 6.4 9.3 4.5 6.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SseC PF04888.12 CDI86564.1 - 0.019 14.6 34.6 0.028 14.0 34.6 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Cyt_bd_oxida_I PF01654.17 CDI86564.1 - 5.6 5.5 14.3 7.1 5.1 14.3 1.1 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit I IPP-2 PF04979.14 CDI86565.1 - 3.4e-09 37.5 7.7 3.8e-09 37.4 7.7 1.1 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) DUF5069 PF16798.5 CDI86565.1 - 0.0092 16.2 2.6 0.0098 16.1 2.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5069) BAT PF15915.5 CDI86565.1 - 0.093 12.6 0.2 0.13 12.2 0.2 1.2 1 0 0 1 1 1 0 GAF and HTH_10 associated domain DUF1512 PF07431.12 CDI86565.1 - 0.14 11.2 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) DUF1640 PF07798.11 CDI86565.1 - 0.17 11.9 9.2 0.19 11.7 9.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF2203 PF09969.9 CDI86565.1 - 0.22 12.2 5.8 0.27 12.0 5.8 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) TSC22 PF01166.18 CDI86565.1 - 0.73 10.2 10.1 1.4 9.3 10.1 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family FapA PF03961.13 CDI86565.1 - 2.2 6.8 8.9 2.2 6.8 8.9 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spt20 PF12090.8 CDI86565.1 - 3.5 7.2 17.9 3.8 7.0 17.9 1.1 1 0 0 1 1 1 0 Spt20 family LCD1 PF09798.9 CDI86565.1 - 8.7 4.7 19.2 9.2 4.6 19.2 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Macoilin PF09726.9 CDI86565.1 - 8.9 4.7 15.1 9.8 4.6 15.1 1.0 1 0 0 1 1 1 0 Macoilin family RskA PF10099.9 CDI86566.1 - 2.5e-08 34.4 0.4 2.5e-08 34.4 0.4 4.1 1 1 3 4 4 4 2 Anti-sigma-K factor rskA DUF4148 PF13663.6 CDI86566.1 - 0.21 11.8 0.1 0.21 11.8 0.1 4.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4148) HC2 PF07382.11 CDI86567.1 - 0.15 12.1 30.1 0.18 11.8 30.1 1.1 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 Merozoite_SPAM PF07133.11 CDI86567.1 - 1.8 8.6 38.0 2.1 8.3 38.0 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DUF2052 PF09747.9 CDI86567.1 - 3 7.9 36.9 3.4 7.8 36.9 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF3138 PF11336.8 CDI86568.1 - 0.22 10.1 2.6 0.27 9.8 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Spt20 PF12090.8 CDI86569.1 - 0.012 15.2 21.3 0.023 14.3 21.3 1.4 1 0 0 1 1 1 0 Spt20 family Lin-8 PF03353.15 CDI86569.1 - 0.15 11.6 12.4 0.3 10.6 12.4 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 CDI86569.1 - 7.5 5.2 10.7 13 4.4 10.7 1.4 1 0 0 1 1 1 0 Presenilin Pex14_N PF04695.13 CDI86570.1 - 0.0031 18.2 29.7 0.0038 17.9 29.7 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region VIT1 PF01988.19 CDI86570.1 - 0.023 14.6 10.9 0.028 14.3 10.9 1.1 1 0 0 1 1 1 0 VIT family SpoIIP PF07454.11 CDI86570.1 - 0.16 11.4 20.2 0.16 11.4 20.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FAM76 PF16046.5 CDI86570.1 - 0.16 11.3 20.8 0.17 11.2 20.8 1.0 1 0 0 1 1 1 0 FAM76 protein PTPRCAP PF15713.5 CDI86570.1 - 0.32 11.3 23.3 0.35 11.2 23.3 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CSG2 PF16965.5 CDI86570.1 - 0.32 9.9 9.8 0.33 9.9 9.8 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator DUF3807 PF12720.7 CDI86570.1 - 0.33 11.2 27.4 0.35 11.1 27.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) NPR3 PF03666.13 CDI86570.1 - 0.58 8.9 17.7 0.55 9.0 17.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DDHD PF02862.17 CDI86570.1 - 0.59 10.3 18.1 0.62 10.2 18.1 1.2 1 0 0 1 1 1 0 DDHD domain BAF1_ABF1 PF04684.13 CDI86570.1 - 0.7 8.9 27.0 0.81 8.7 27.0 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor ABC2_membrane_2 PF12679.7 CDI86570.1 - 0.73 9.1 9.9 1 8.6 9.9 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Draxin PF15550.6 CDI86570.1 - 0.83 9.5 15.4 0.94 9.3 15.4 1.0 1 0 0 1 1 1 0 Draxin Lin-8 PF03353.15 CDI86570.1 - 0.85 9.1 25.4 0.85 9.1 25.4 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TFIIA PF03153.13 CDI86570.1 - 0.87 9.5 52.4 1.1 9.2 52.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EFTUD2 PF16004.5 CDI86570.1 - 0.95 10.1 19.3 1.3 9.6 19.3 1.4 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Tim54 PF11711.8 CDI86570.1 - 1.1 8.0 18.7 1.1 7.9 18.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Eapp_C PF10238.9 CDI86570.1 - 1.4 9.0 22.5 1.7 8.8 22.5 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF4746 PF15928.5 CDI86570.1 - 1.5 8.2 14.5 1.4 8.2 14.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Mem_trans PF03547.18 CDI86570.1 - 1.6 7.0 8.9 1.8 6.9 8.9 1.2 1 0 0 1 1 1 0 Membrane transport protein ALMT PF11744.8 CDI86570.1 - 1.7 7.4 19.0 1.8 7.3 19.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4638 PF15472.6 CDI86570.1 - 1.8 8.3 18.4 1.8 8.2 18.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) BORG_CEP PF14957.6 CDI86570.1 - 1.9 9.6 12.3 2.1 9.5 12.3 1.3 1 0 0 1 1 1 0 Cdc42 effector AF-4 PF05110.13 CDI86570.1 - 2.2 6.3 24.9 2.2 6.3 24.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CDC45 PF02724.14 CDI86570.1 - 2.2 6.4 19.3 2.4 6.4 19.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Velvet PF11754.8 CDI86570.1 - 2.3 8.1 18.6 2.2 8.2 18.6 1.2 1 0 0 1 1 1 0 Velvet factor DUF4050 PF13259.6 CDI86570.1 - 3 8.1 17.8 3.4 7.9 17.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Calici_coat_C PF08435.11 CDI86570.1 - 3.1 7.2 17.2 3.6 7.0 17.2 1.0 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal EOS1 PF12326.8 CDI86570.1 - 3.1 7.7 12.7 3.7 7.4 12.7 1.3 1 0 0 1 1 1 0 N-glycosylation protein SLC12 PF03522.15 CDI86570.1 - 3.4 6.6 22.7 3.4 6.6 22.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 MDM10 PF12519.8 CDI86570.1 - 3.4 6.4 19.3 3.4 6.4 19.3 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 FRQ PF09421.10 CDI86570.1 - 3.5 5.5 15.2 4.1 5.3 15.2 1.1 1 0 0 1 1 1 0 Frequency clock protein Peptidase_S64 PF08192.11 CDI86570.1 - 3.7 5.9 18.3 3.6 5.9 18.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 FAM176 PF14851.6 CDI86570.1 - 3.8 7.2 14.8 4.6 6.9 14.8 1.2 1 0 0 1 1 1 0 FAM176 family Piezo_RRas_bdg PF12166.8 CDI86570.1 - 4.4 6.5 13.7 4.9 6.3 13.7 1.1 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain YABBY PF04690.13 CDI86570.1 - 4.5 7.8 17.8 5 7.7 17.8 1.1 1 0 0 1 1 1 0 YABBY protein Connexin PF00029.19 CDI86570.1 - 4.7 6.9 18.9 5 6.8 18.9 1.1 1 0 0 1 1 1 0 Connexin Endostatin PF06482.11 CDI86570.1 - 4.8 6.5 20.4 4.9 6.5 20.4 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Folate_carrier PF01770.18 CDI86570.1 - 4.9 5.8 10.8 5.3 5.7 10.8 1.3 1 0 0 1 1 1 0 Reduced folate carrier Membralin PF09746.9 CDI86570.1 - 5.2 6.0 13.9 5.1 6.0 13.9 1.0 1 0 0 1 1 1 0 Tumour-associated protein Band_3_cyto PF07565.13 CDI86570.1 - 5.3 6.8 20.3 5.8 6.6 20.3 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain eIF-3_zeta PF05091.12 CDI86570.1 - 5.3 5.9 32.7 5.7 5.8 32.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PPL5 PF18168.1 CDI86570.1 - 5.5 6.2 16.4 6.1 6.0 16.4 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Auxin_canalis PF05703.11 CDI86570.1 - 5.6 6.8 29.8 7.2 6.5 29.8 1.1 1 0 0 1 1 1 0 Auxin canalisation HGTP_anticodon2 PF12745.7 CDI86570.1 - 5.7 6.4 26.2 6.3 6.2 26.2 1.0 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs DUF913 PF06025.12 CDI86570.1 - 6.3 5.7 14.2 6.2 5.7 14.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) MCM_bind PF09739.9 CDI86570.1 - 6.5 5.1 19.0 6.5 5.1 19.0 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Hid1 PF12722.7 CDI86570.1 - 6.6 4.7 19.7 5.9 4.9 19.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Rtf2 PF04641.12 CDI86570.1 - 6.7 6.0 19.8 7 5.9 19.8 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Plasmodium_Vir PF05795.11 CDI86570.1 - 7 6.0 11.1 7.4 5.9 11.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Dsh_C PF12316.8 CDI86570.1 - 7.2 6.9 17.8 8.5 6.7 17.8 1.0 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Pinin_SDK_memA PF04696.13 CDI86570.1 - 7.4 6.6 37.6 8.7 6.4 37.6 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region dsRBD2 PF17842.1 CDI86570.1 - 7.8 6.7 14.5 11 6.2 14.5 1.3 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 Cellulose_synt PF03552.14 CDI86570.1 - 7.9 4.8 8.9 7.5 4.9 8.9 1.0 1 0 0 1 1 1 0 Cellulose synthase FAM91_C PF14648.6 CDI86570.1 - 8.2 5.1 12.2 8.3 5.1 12.2 1.1 1 0 0 1 1 1 0 FAM91 C-terminus DUF3295 PF11702.8 CDI86570.1 - 8.9 5.5 23.4 9.3 5.5 23.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) SAPS PF04499.15 CDI86570.1 - 9 5.0 15.5 8.4 5.1 15.5 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 CDI86570.1 - 9.2 4.9 29.3 10 4.8 29.3 1.1 1 0 0 1 1 1 0 Presenilin DUF72 PF01904.18 CDI86572.1 - 0.012 15.7 0.1 0.019 15.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF72 PmbA_TldD PF01523.16 CDI86575.1 - 0.59 9.9 19.8 0.83 9.4 19.8 1.1 1 0 0 1 1 1 0 Putative modulator of DNA gyrase DUF572 PF04502.13 CDI86575.1 - 1.1 8.9 7.6 1.3 8.6 7.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Apt1 PF10351.9 CDI86575.1 - 1.2 7.9 17.5 1.5 7.6 17.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Utp14 PF04615.13 CDI86575.1 - 1.2 7.6 14.7 1.4 7.4 14.7 1.1 1 0 0 1 1 1 0 Utp14 protein SPX PF03105.19 CDI86575.1 - 1.5 8.6 18.7 1.7 8.4 18.7 1.1 1 0 0 1 1 1 0 SPX domain RskA PF10099.9 CDI86575.1 - 1.6 9.0 33.5 2.4 8.4 18.2 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Myc_N PF01056.18 CDI86575.1 - 3 7.6 15.1 3.9 7.3 15.1 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Presenilin PF01080.17 CDI86575.1 - 5.8 5.6 10.1 7.3 5.2 10.1 1.2 1 0 0 1 1 1 0 Presenilin Spore_coat_CotO PF14153.6 CDI86575.1 - 7.6 6.4 5.5 5.2 7.0 4.5 1.4 1 1 0 1 1 1 0 Spore coat protein CotO MDM10 PF12519.8 CDI86579.1 - 4.7 6.0 40.8 6.3 5.5 40.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CDC45 PF02724.14 CDI86579.1 - 7.3 4.7 47.7 8.5 4.5 47.7 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF445 PF04286.12 CDI86580.1 - 1.1 8.9 29.6 1.8 8.3 29.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DREPP PF05558.12 CDI86581.1 - 0.0048 16.8 3.4 1.1 9.1 0.9 2.2 2 0 0 2 2 2 2 DREPP plasma membrane polypeptide DivIC PF04977.15 CDI86581.1 - 0.022 14.5 1.6 0.022 14.5 1.6 5.6 2 1 3 5 5 5 0 Septum formation initiator TRAP_alpha PF03896.16 CDI86581.1 - 0.03 13.5 10.6 0.06 12.5 3.1 2.3 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit MLANA PF14991.6 CDI86581.1 - 0.12 12.7 0.3 0.12 12.7 0.3 3.8 3 1 1 4 4 4 0 Protein melan-A SpoIIIAH PF12685.7 CDI86581.1 - 0.63 9.8 29.0 0.7 9.7 17.5 2.7 2 1 0 2 2 2 0 SpoIIIAH-like protein Ac76 PF05814.11 CDI86581.1 - 3.7 7.6 6.6 52 4.0 6.6 2.8 1 1 0 1 1 1 0 Orf76 (Ac76) TPR_8 PF13181.6 CDI86582.1 - 0.0035 17.4 2.8 0.035 14.3 1.0 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI86582.1 - 0.0059 17.3 15.4 0.019 15.7 4.3 4.2 2 1 1 4 4 4 1 Tetratricopeptide repeat Wzy_C_2 PF11846.8 CDI86582.1 - 0.022 14.7 1.6 0.028 14.4 1.2 1.4 1 1 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal TPR_12 PF13424.6 CDI86582.1 - 0.023 14.9 4.7 0.023 14.9 4.7 2.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDI86582.1 - 0.039 13.8 5.1 0.24 11.3 1.7 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDI86582.1 - 0.046 13.8 2.2 0.046 13.8 2.2 3.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDI86582.1 - 0.052 13.6 5.2 0.73 10.0 1.6 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 CDI86582.1 - 0.074 12.1 1.8 0.085 11.9 1.8 1.1 1 0 0 1 1 1 0 Coatomer WD associated region SNAP PF14938.6 CDI86582.1 - 0.096 12.1 8.3 0.22 10.9 8.3 1.5 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_4 PF07721.14 CDI86582.1 - 0.11 13.2 0.1 0.11 13.2 0.1 5.1 3 1 3 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDI86582.1 - 0.16 11.9 12.2 0.24 11.3 0.9 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDI86582.1 - 0.22 12.2 0.8 0.22 12.2 0.8 3.6 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDI86582.1 - 0.6 9.9 5.6 8.3 6.2 0.4 3.8 3 1 1 4 4 4 0 TPR repeat TPR_19 PF14559.6 CDI86582.1 - 0.64 10.6 9.9 4.8 7.8 6.9 3.2 1 1 2 3 3 3 0 Tetratricopeptide repeat V_ATPase_I PF01496.19 CDI86583.1 - 5.6e-06 24.6 10.4 6.8e-06 24.3 10.4 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family TRAP_alpha PF03896.16 CDI86583.1 - 6.3e-05 22.3 4.7 8.8e-05 21.8 4.7 1.3 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit SID-1_RNA_chan PF13965.6 CDI86583.1 - 0.00022 19.8 0.8 0.00023 19.7 0.8 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 CLN3 PF02487.17 CDI86583.1 - 0.00028 20.1 4.3 0.00032 19.9 4.3 1.0 1 0 0 1 1 1 1 CLN3 protein SARAF PF06682.12 CDI86583.1 - 0.00038 20.2 0.8 0.00046 19.9 0.8 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Adipogenin PF15202.6 CDI86583.1 - 0.00063 19.7 0.8 0.0011 19.0 0.8 1.5 1 0 0 1 1 1 1 Adipogenin Peptidase_S49_N PF08496.10 CDI86583.1 - 0.0013 18.8 5.9 0.0016 18.5 5.9 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal OATP PF03137.20 CDI86583.1 - 0.0013 17.1 0.6 0.0017 16.7 0.6 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family CSG2 PF16965.5 CDI86583.1 - 0.0014 17.7 2.8 0.0016 17.5 2.8 1.1 1 0 0 1 1 1 1 Ceramide synthase regulator Ctr PF04145.15 CDI86583.1 - 0.0018 18.9 1.5 0.0022 18.6 1.5 1.2 1 0 0 1 1 1 1 Ctr copper transporter family MMM1 PF10296.9 CDI86583.1 - 0.003 16.7 1.7 0.0034 16.5 1.7 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 CCDC53 PF10152.9 CDI86583.1 - 0.0032 17.9 10.6 0.0038 17.7 10.6 1.1 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex DUF4446 PF14584.6 CDI86583.1 - 0.0046 16.9 4.3 0.006 16.6 4.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4446) DUF3328 PF11807.8 CDI86583.1 - 0.0051 16.6 0.6 0.012 15.4 0.5 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF3328) Serinc PF03348.15 CDI86583.1 - 0.01 14.8 2.2 0.013 14.5 2.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) CBP_BcsG PF11658.8 CDI86583.1 - 0.012 14.1 3.8 0.013 13.9 3.8 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG SpoIIP PF07454.11 CDI86583.1 - 0.012 15.1 12.1 0.013 14.9 12.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF2254 PF10011.9 CDI86583.1 - 0.012 14.4 0.5 0.015 14.1 0.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) PIP5K PF01504.18 CDI86583.1 - 0.013 14.8 5.1 0.015 14.6 5.1 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase O-antigen_lig PF13425.6 CDI86583.1 - 0.016 14.0 1.4 0.02 13.7 1.4 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PSK PF06404.12 CDI86583.1 - 0.018 16.0 9.2 0.029 15.4 9.2 1.4 1 0 0 1 1 1 0 Phytosulfokine precursor protein (PSK) PPL5 PF18168.1 CDI86583.1 - 0.021 14.1 8.2 0.025 13.9 8.2 1.0 1 0 0 1 1 1 0 Prim-pol family 5 DUF2828 PF11443.8 CDI86583.1 - 0.034 12.2 9.4 0.04 12.0 9.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Pex24p PF06398.11 CDI86583.1 - 0.041 12.9 0.2 0.059 12.3 0.2 1.3 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF4220 PF13968.6 CDI86583.1 - 0.064 12.6 0.2 0.069 12.5 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) DUF4834 PF16118.5 CDI86583.1 - 0.065 14.2 23.7 0.32 12.0 23.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) COPI_C PF06957.11 CDI86583.1 - 0.067 11.9 11.1 0.073 11.8 11.1 1.0 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus CobT PF06213.12 CDI86583.1 - 0.07 12.5 26.4 0.08 12.3 26.4 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Scs3p PF10261.9 CDI86583.1 - 0.088 12.3 2.2 0.12 11.8 2.2 1.3 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM SLC12 PF03522.15 CDI86583.1 - 0.11 11.5 11.1 0.12 11.3 11.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Asparaginase_2 PF01112.18 CDI86583.1 - 0.16 11.0 5.1 0.18 10.8 5.1 1.1 1 0 0 1 1 1 0 Asparaginase HemX PF04375.14 CDI86583.1 - 0.19 11.0 27.0 0.21 10.8 27.0 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2232 PF09991.9 CDI86583.1 - 0.22 10.7 4.9 0.26 10.4 4.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DUF913 PF06025.12 CDI86583.1 - 0.32 9.9 7.2 0.36 9.8 7.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3810 PF12725.7 CDI86583.1 - 0.38 10.1 2.9 0.41 9.9 2.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) RPN2_C PF18004.1 CDI86583.1 - 0.39 10.6 14.7 0.52 10.2 14.7 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain FemAB PF02388.16 CDI86583.1 - 0.43 9.4 14.0 0.47 9.3 14.0 1.0 1 0 0 1 1 1 0 FemAB family Band_3_cyto PF07565.13 CDI86583.1 - 0.44 10.3 11.4 0.53 10.0 11.4 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Myc_N PF01056.18 CDI86583.1 - 0.48 10.3 13.2 0.59 10.0 13.2 1.1 1 0 0 1 1 1 0 Myc amino-terminal region F-protein PF00469.20 CDI86583.1 - 0.51 9.9 13.9 0.61 9.6 13.9 1.0 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Afi1 PF07792.12 CDI86583.1 - 0.55 10.7 15.3 0.74 10.3 15.3 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking YABBY PF04690.13 CDI86583.1 - 0.64 10.6 8.3 0.75 10.3 8.3 1.1 1 0 0 1 1 1 0 YABBY protein Vfa1 PF08432.10 CDI86583.1 - 0.69 10.2 17.4 0.8 10.0 17.4 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DDHD PF02862.17 CDI86583.1 - 0.75 9.9 10.8 0.91 9.6 10.8 1.1 1 0 0 1 1 1 0 DDHD domain BORG_CEP PF14957.6 CDI86583.1 - 0.75 11.0 8.2 0.96 10.6 8.2 1.2 1 0 0 1 1 1 0 Cdc42 effector DUF1180 PF06679.12 CDI86583.1 - 0.82 10.1 13.9 1.6 9.1 13.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) DUF3974 PF13120.6 CDI86583.1 - 0.87 9.7 3.6 1.1 9.3 3.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3974) NOA36 PF06524.12 CDI86583.1 - 0.88 8.8 11.3 1 8.6 11.3 1.0 1 0 0 1 1 1 0 NOA36 protein UPF0565 PF10561.9 CDI86583.1 - 0.9 8.7 7.5 1.1 8.4 7.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Saw1 PF11561.8 CDI86583.1 - 0.97 8.9 14.0 1.2 8.7 14.0 1.1 1 0 0 1 1 1 0 Single strand annealing-weakened 1 DUF2370 PF10176.9 CDI86583.1 - 1.1 8.9 5.2 1.2 8.7 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF3438 PF11920.8 CDI86583.1 - 1.4 8.1 11.2 1.7 7.8 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) DUF5385 PF17359.2 CDI86583.1 - 1.5 8.3 16.6 1.2 8.6 0.1 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5385) DUF4746 PF15928.5 CDI86583.1 - 1.6 8.0 20.5 1.9 7.8 20.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Gti1_Pac2 PF09729.9 CDI86583.1 - 1.8 8.6 10.6 2.2 8.3 10.6 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Tim54 PF11711.8 CDI86583.1 - 1.8 7.2 16.1 2.1 7.0 16.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2126 PF09899.9 CDI86583.1 - 2.2 6.3 11.1 2.5 6.1 11.1 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) FAM176 PF14851.6 CDI86583.1 - 2.2 7.9 21.4 1.6e+02 1.9 21.4 2.0 1 1 0 1 1 1 0 FAM176 family RR_TM4-6 PF06459.12 CDI86583.1 - 2.5 7.8 19.5 3.1 7.6 19.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Endonuc_Holl PF10107.9 CDI86583.1 - 2.6 7.9 12.2 3.3 7.6 12.2 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Cellulose_synt PF03552.14 CDI86583.1 - 2.8 6.3 6.4 3.4 6.1 6.4 1.1 1 0 0 1 1 1 0 Cellulose synthase Gemini_mov PF01708.16 CDI86583.1 - 2.8 7.7 10.0 0.32 10.8 4.8 1.9 1 1 1 2 2 2 0 Geminivirus putative movement protein PhoR PF11808.8 CDI86583.1 - 3.1 8.3 14.5 5 7.6 14.5 1.5 1 1 0 1 1 1 0 Phosphate regulon sensor protein PhoR NPR3 PF03666.13 CDI86583.1 - 3.4 6.4 14.1 4.2 6.1 14.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pex14_N PF04695.13 CDI86583.1 - 3.4 8.3 17.6 4.6 7.9 17.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 CDI86583.1 - 3.6 7.5 34.2 4.3 7.2 34.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Connexin PF00029.19 CDI86583.1 - 3.8 7.2 16.5 5.5 6.7 16.4 1.3 1 1 0 1 1 1 0 Connexin eIF-3_zeta PF05091.12 CDI86583.1 - 3.8 6.4 20.0 4.6 6.1 20.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Tmemb_9 PF05434.11 CDI86583.1 - 4 7.3 19.2 17 5.3 19.2 1.9 1 1 0 1 1 1 0 TMEM9 Nucleoside_tran PF01733.18 CDI86583.1 - 4.2 6.7 9.5 12 5.1 9.5 1.7 1 1 0 1 1 1 0 Nucleoside transporter TFB6 PF17110.5 CDI86583.1 - 4.4 7.0 12.2 6.9 6.4 12.2 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RskA PF10099.9 CDI86583.1 - 4.5 7.5 14.3 45 4.3 14.3 1.9 1 1 0 1 1 1 0 Anti-sigma-K factor rskA FAM60A PF15396.6 CDI86583.1 - 5.1 7.0 10.8 6.1 6.8 10.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CDC45 PF02724.14 CDI86583.1 - 5.5 5.2 17.7 6.3 5.0 17.7 1.0 1 0 0 1 1 1 0 CDC45-like protein ALMT PF11744.8 CDI86583.1 - 5.6 5.7 11.6 6.4 5.5 11.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Ureide_permease PF07168.11 CDI86583.1 - 6.3 5.4 8.2 8.6 5.0 8.2 1.2 1 0 0 1 1 1 0 Ureide permease MRP-S26 PF14943.6 CDI86583.1 - 7.5 6.4 23.1 9.2 6.1 23.1 1.0 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Peptidase_S64 PF08192.11 CDI86583.1 - 7.6 4.9 14.1 8.3 4.8 14.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Paf1 PF03985.13 CDI86583.1 - 7.9 5.4 27.5 9.3 5.1 27.5 1.0 1 0 0 1 1 1 0 Paf1 DUF2347 PF09804.9 CDI86583.1 - 8.5 5.9 11.5 10 5.6 11.5 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Folate_carrier PF01770.18 CDI86583.1 - 9.4 4.9 11.0 15 4.2 11.0 1.4 1 1 0 1 1 1 0 Reduced folate carrier PAT1 PF09770.9 CDI86583.1 - 9.9 4.3 24.0 11 4.2 24.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MLANA PF14991.6 CDI86583.1 - 10 6.5 6.6 24 5.2 6.6 1.8 1 1 0 1 1 1 0 Protein melan-A Ras PF00071.22 CDI86584.1 - 4.4e-37 127.2 0.9 5.9e-27 94.2 0.1 2.0 1 1 1 2 2 2 2 Ras family Roc PF08477.13 CDI86584.1 - 2.5e-25 89.0 0.4 1.7e-17 63.7 0.0 2.0 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI86584.1 - 0.00068 19.1 0.2 0.0023 17.4 0.1 1.7 1 1 1 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDI86584.1 - 0.11 12.0 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF1846 PF08903.11 CDI86585.1 - 1.9 7.0 3.7 3.4 6.1 3.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) Peptidase_C48 PF02902.19 CDI86586.1 - 4e-07 30.1 0.0 9e-07 28.9 0.0 1.5 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain RIC3 PF15361.6 CDI86587.1 - 0.0065 16.9 18.1 0.065 13.6 0.7 2.1 2 0 0 2 2 2 2 Resistance to inhibitors of cholinesterase homologue 3 SARAF PF06682.12 CDI86587.1 - 0.0069 16.1 15.1 0.16 11.6 3.4 2.2 2 0 0 2 2 2 2 SOCE-associated regulatory factor of calcium homoeostasis Spore_coat_CotO PF14153.6 CDI86587.1 - 0.0071 16.3 30.4 0.041 13.8 7.8 2.2 2 0 0 2 2 2 2 Spore coat protein CotO FAM176 PF14851.6 CDI86587.1 - 0.0078 15.9 2.6 1.3 8.6 1.0 2.2 2 0 0 2 2 2 1 FAM176 family DUF1115 PF06544.12 CDI86587.1 - 0.011 15.8 0.2 0.011 15.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1115) DUF2076 PF09849.9 CDI86587.1 - 0.014 15.5 8.4 0.014 15.5 8.4 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF4834 PF16118.5 CDI86587.1 - 0.015 16.3 18.4 0.31 12.0 4.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) G0-G1_switch_2 PF15103.6 CDI86587.1 - 0.019 15.4 9.8 0.22 12.0 0.1 2.2 2 0 0 2 2 2 0 G0/G1 switch protein 2 Tau95_N PF17682.1 CDI86587.1 - 0.031 14.5 1.1 0.031 14.5 1.1 2.2 2 0 0 2 2 2 0 Tau95 Triple barrel domain PIG-U PF06728.13 CDI86587.1 - 0.034 13.2 0.1 0.042 12.9 0.1 1.1 1 0 0 1 1 1 0 GPI transamidase subunit PIG-U DUF979 PF06166.12 CDI86587.1 - 0.034 13.3 0.2 0.034 13.3 0.2 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF979) CCDC53 PF10152.9 CDI86587.1 - 0.052 14.0 22.7 0.54 10.7 3.3 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex DUF3408 PF11888.8 CDI86587.1 - 0.069 13.3 20.3 0.15 12.2 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) BRF1 PF07741.13 CDI86587.1 - 0.083 13.2 0.4 0.083 13.2 0.4 2.3 2 0 0 2 2 2 0 Brf1-like TBP-binding domain BORG_CEP PF14957.6 CDI86587.1 - 0.097 13.8 11.9 1.7 9.8 5.1 2.1 2 0 0 2 2 2 0 Cdc42 effector DUF4820 PF16091.5 CDI86587.1 - 0.14 11.5 11.5 0.68 9.3 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) MAM33 PF02330.16 CDI86587.1 - 0.2 11.6 0.0 0.2 11.6 0.0 2.1 2 0 0 2 2 1 0 Mitochondrial glycoprotein YABBY PF04690.13 CDI86587.1 - 0.2 12.2 11.4 2.1 8.9 0.6 2.1 2 0 0 2 2 2 0 YABBY protein Mlh1_C PF16413.5 CDI86587.1 - 0.25 10.7 10.9 1 8.7 0.4 2.1 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus DUF2062 PF09835.9 CDI86587.1 - 0.25 11.2 3.4 0.53 10.1 3.4 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) DUF3292 PF11696.8 CDI86587.1 - 0.3 9.4 14.6 0.32 9.3 5.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) SpoIIP PF07454.11 CDI86587.1 - 0.34 10.3 19.5 1.3 8.4 7.1 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) CLN3 PF02487.17 CDI86587.1 - 0.39 9.7 10.7 1.9 7.4 5.1 2.1 2 0 0 2 2 2 0 CLN3 protein EPL1 PF10513.9 CDI86587.1 - 0.41 11.0 20.8 0.27 11.6 1.7 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like Peroxin-13_N PF04088.13 CDI86587.1 - 0.44 10.8 8.2 3 8.1 0.3 2.1 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Coilin_N PF15862.5 CDI86587.1 - 0.48 10.2 23.4 0.63 9.8 6.0 2.2 2 0 0 2 2 2 0 Coilin N-terminus RR_TM4-6 PF06459.12 CDI86587.1 - 0.52 10.1 16.3 1.6 8.5 5.8 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 CDI86587.1 - 0.61 9.0 23.3 1.5 7.8 8.7 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF5308 PF17233.2 CDI86587.1 - 0.63 10.2 23.4 1.1 9.5 13.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5308) CobT PF06213.12 CDI86587.1 - 0.64 9.4 26.7 0.29 10.5 10.5 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Rrp15p PF07890.12 CDI86587.1 - 0.7 10.2 20.9 0.052 13.9 2.6 2.2 2 0 0 2 2 2 0 Rrp15p CTU2 PF10288.9 CDI86587.1 - 0.75 10.1 15.4 2 8.7 3.2 2.2 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 NEMP PF10225.9 CDI86587.1 - 0.8 9.3 9.3 0.51 10.0 1.8 2.1 2 0 0 2 2 2 0 NEMP family EIIBC-GUT_N PF03612.14 CDI86587.1 - 1 9.1 16.8 2.5 7.8 3.3 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus DUF719 PF05334.13 CDI86587.1 - 1.1 9.4 15.7 3.9 7.6 1.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF719) DUF5327 PF17261.2 CDI86587.1 - 1.4 9.7 32.1 0.39 11.5 11.7 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5327) Pap_E4 PF02711.14 CDI86587.1 - 1.5 9.9 22.4 3.7 8.6 1.7 2.3 2 0 0 2 2 2 0 E4 protein Band_3_cyto PF07565.13 CDI86587.1 - 1.6 8.5 21.0 1 9.1 0.5 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Presenilin PF01080.17 CDI86587.1 - 1.6 7.4 23.3 2.6 6.7 23.3 1.3 1 1 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI86587.1 - 1.6 8.7 14.1 4.2 7.3 1.6 2.1 2 0 0 2 2 2 0 Protein Family FAM60A DUF2407 PF10302.9 CDI86587.1 - 2.5 8.7 9.9 5.5 7.6 0.9 2.2 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain DUF4175 PF13779.6 CDI86587.1 - 2.6 5.9 44.6 0.84 7.5 22.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) Tim54 PF11711.8 CDI86587.1 - 2.7 6.7 17.4 0.69 8.6 0.8 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Orf78 PF06024.12 CDI86587.1 - 2.8 8.3 13.7 0.88 9.9 0.3 2.3 2 0 0 2 2 2 0 Orf78 (ac78) eIF_4EBP PF05456.11 CDI86587.1 - 3.8 7.5 21.2 1.5 8.8 7.3 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Spt20 PF12090.8 CDI86587.1 - 3.9 7.0 64.7 0.27 10.8 20.8 2.2 2 0 0 2 2 2 0 Spt20 family PIP5K PF01504.18 CDI86587.1 - 4 6.6 15.8 6.8 5.8 15.8 1.4 1 1 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase RskA PF10099.9 CDI86587.1 - 4.5 7.5 30.8 1.7 8.9 15.4 2.4 1 1 1 2 2 2 0 Anti-sigma-K factor rskA ATAD4 PF15321.6 CDI86587.1 - 4.6 8.7 14.7 5.1 8.5 0.9 2.2 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Baculo_PP31 PF05311.11 CDI86587.1 - 4.8 6.6 17.5 2.9 7.3 2.8 2.1 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) AIF_C PF14721.6 CDI86587.1 - 6.4 7.1 15.6 1.7 9.0 0.6 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term ORC_WH_C PF18137.1 CDI86587.1 - 6.7 6.8 18.0 7.4 6.6 4.6 2.3 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Spc7_N PF15402.6 CDI86587.1 - 7.9 4.6 19.6 3.9 5.6 9.2 2.0 2 0 0 2 2 2 0 N-terminus of kinetochore NMS complex subunit Spc7 UPF0239 PF06783.11 CDI86587.1 - 9 6.6 13.8 3.1 8.0 1.5 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) WD40 PF00400.32 CDI86588.1 - 5.7e-19 68.1 9.5 4.1e-07 30.6 0.8 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI86588.1 - 8.5e-10 38.8 3.7 0.019 15.2 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Spt20 PF12090.8 CDI86588.1 - 0.0009 18.9 46.2 0.016 14.8 14.9 2.1 2 0 0 2 2 2 2 Spt20 family Androgen_recep PF02166.16 CDI86588.1 - 0.00095 18.1 33.2 0.021 13.7 8.1 2.0 2 0 0 2 2 2 2 Androgen receptor DUF4834 PF16118.5 CDI86588.1 - 0.0011 19.8 19.1 0.02 15.8 3.8 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) DUF4820 PF16091.5 CDI86588.1 - 0.0014 18.1 10.2 0.05 13.0 1.2 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4820) Nbas_N PF15492.6 CDI86588.1 - 0.0026 17.1 0.7 0.0026 17.1 0.7 2.0 1 1 1 2 2 2 1 Neuroblastoma-amplified sequence, N terminal Presenilin PF01080.17 CDI86588.1 - 0.0039 16.0 13.3 0.005 15.7 13.3 1.1 1 0 0 1 1 1 1 Presenilin ANAPC_CDC26 PF10471.9 CDI86588.1 - 0.0075 17.1 38.0 0.2 12.5 16.6 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex APC subunit CDC26 Rtf2 PF04641.12 CDI86588.1 - 0.016 14.6 8.4 0.021 14.2 8.4 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger SMYLE_N PF18615.1 CDI86588.1 - 0.016 14.8 9.2 0.021 14.4 9.2 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain PTPRCAP PF15713.5 CDI86588.1 - 0.017 15.4 14.5 0.11 12.7 3.0 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated RAB3GAP2_N PF14655.6 CDI86588.1 - 0.017 14.4 2.9 0.017 14.4 2.9 2.7 2 1 1 3 3 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus CPSF100_C PF13299.6 CDI86588.1 - 0.019 15.1 9.1 0.3 11.3 1.1 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF5308 PF17233.2 CDI86588.1 - 0.031 14.5 10.0 0.79 9.9 1.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5308) PIP5K PF01504.18 CDI86588.1 - 0.032 13.5 8.3 0.045 13.0 8.3 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase TERB2 PF15101.6 CDI86588.1 - 0.033 14.2 18.8 0.59 10.2 5.3 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF3807 PF12720.7 CDI86588.1 - 0.04 14.2 18.0 0.67 10.2 4.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) CFIA_Pcf11 PF11526.8 CDI86588.1 - 0.041 14.4 14.4 0.15 12.6 2.6 2.2 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 Spore_YhcN_YlaJ PF09580.10 CDI86588.1 - 0.049 13.7 11.1 0.081 13.0 11.1 1.3 1 1 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF2722 PF10846.8 CDI86588.1 - 0.06 12.3 42.6 0.3 10.0 18.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF702 PF05142.12 CDI86588.1 - 0.066 13.7 15.6 0.56 10.7 4.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Oleosin PF01277.17 CDI86588.1 - 0.092 12.5 2.6 0.86 9.4 0.2 2.1 2 0 0 2 2 2 0 Oleosin SLC12 PF03522.15 CDI86588.1 - 0.13 11.3 11.8 0.15 11.0 11.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF1676 PF07898.13 CDI86588.1 - 0.13 12.3 3.8 2 8.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Afi1 PF07792.12 CDI86588.1 - 0.16 12.5 14.1 0.33 11.4 2.5 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MAGE PF01454.19 CDI86588.1 - 0.18 11.5 12.2 0.034 13.9 2.1 2.1 2 0 0 2 2 2 0 MAGE family DUF4355 PF14265.6 CDI86588.1 - 0.23 11.7 22.2 0.77 10.0 5.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) EPL1 PF10513.9 CDI86588.1 - 0.27 11.6 18.2 0.43 10.9 4.1 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like PH_4 PF15404.6 CDI86588.1 - 0.3 10.8 11.0 0.55 10.0 1.5 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain TFB6 PF17110.5 CDI86588.1 - 0.33 10.7 10.3 1.5 8.5 0.9 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Fer4_18 PF13746.6 CDI86588.1 - 0.35 11.1 8.6 0.56 10.4 1.3 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain EphA2_TM PF14575.6 CDI86588.1 - 0.39 11.6 8.9 2.6 9.0 1.3 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain CRF1 PF10380.9 CDI86588.1 - 0.4 11.1 5.7 3.6 8.0 0.5 2.2 2 0 0 2 2 2 0 Transcription factor CRF1 HA2 PF04408.23 CDI86588.1 - 0.43 10.9 4.5 11 6.4 0.3 2.2 2 0 0 2 2 2 0 Helicase associated domain (HA2) Slu7 PF11708.8 CDI86588.1 - 0.45 10.2 17.5 0.57 9.9 4.2 2.1 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor MAT1 PF06391.13 CDI86588.1 - 0.51 10.1 19.0 0.95 9.2 5.7 2.0 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Rpp20 PF12328.8 CDI86588.1 - 0.52 10.3 14.9 0.45 10.5 2.0 2.2 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Porph_ging PF09697.10 CDI86588.1 - 0.53 10.9 9.5 3.8 8.1 2.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) Usp PF00582.26 CDI86588.1 - 0.58 10.7 3.9 6.6 7.2 0.3 2.1 2 0 0 2 2 2 0 Universal stress protein family FYDLN_acid PF09538.10 CDI86588.1 - 0.71 10.6 10.3 2.2 9.0 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF4628 PF15429.6 CDI86588.1 - 0.74 9.4 12.7 2.5 7.7 2.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4628) CagX PF03524.15 CDI86588.1 - 0.75 9.5 10.9 1.6 8.4 1.8 2.1 2 0 0 2 2 2 0 Conjugal transfer protein MAPEG PF01124.18 CDI86588.1 - 0.87 9.5 1.9 14 5.6 0.1 2.2 2 0 0 2 2 2 0 MAPEG family ATAD4 PF15321.6 CDI86588.1 - 0.99 10.8 10.2 3.5 9.0 1.1 2.2 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Peroxin-13_N PF04088.13 CDI86588.1 - 1 9.7 8.5 4.5 7.5 0.7 2.1 2 0 0 2 2 2 0 Peroxin 13, N-terminal region TMEM51 PF15345.6 CDI86588.1 - 1.2 8.9 21.5 0.041 13.7 2.5 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 DUF5523 PF17661.1 CDI86588.1 - 1.4 8.6 18.5 0.77 9.4 4.2 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Roughex PF06020.11 CDI86588.1 - 1.4 8.0 23.7 1.6 7.7 8.0 2.1 2 0 0 2 2 2 0 Drosophila roughex protein BCIP PF13862.6 CDI86588.1 - 1.4 8.7 9.3 5.8 6.6 0.4 2.1 2 0 0 2 2 2 0 p21-C-terminal region-binding protein DUF2681 PF10883.8 CDI86588.1 - 1.4 9.4 30.8 0.53 10.7 9.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF2407 PF10302.9 CDI86588.1 - 1.5 9.4 6.2 10 6.7 0.4 2.2 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain Rsc14 PF08586.10 CDI86588.1 - 1.6 9.6 10.5 4.5 8.1 1.0 2.2 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit CNDH2_M PF16869.5 CDI86588.1 - 1.6 9.4 11.0 3.1 8.5 0.5 2.1 2 0 0 2 2 2 0 PF16858 DUF4207 PF13904.6 CDI86588.1 - 1.7 8.3 32.8 1.7 8.3 10.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) RPN2_C PF18004.1 CDI86588.1 - 1.7 8.5 13.9 2.5 8.0 1.9 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain RskA PF10099.9 CDI86588.1 - 1.9 8.8 19.8 3.8e+03 -2.0 19.8 2.1 1 1 0 1 1 0 0 Anti-sigma-K factor rskA Folliculin PF11704.8 CDI86588.1 - 2 8.3 13.0 5.4 6.9 4.9 2.0 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport ORC_WH_C PF18137.1 CDI86588.1 - 2.1 8.4 18.8 1.5 8.8 7.0 2.1 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal DUF3408 PF11888.8 CDI86588.1 - 2.3 8.4 16.6 2 8.6 3.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Fes1 PF08609.10 CDI86588.1 - 2.3 9.1 9.0 13 6.8 1.2 2.4 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 CRA PF06589.11 CDI86588.1 - 2.5 8.2 6.1 4.6 7.4 0.4 2.1 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) MPM1 PF17234.2 CDI86588.1 - 3 8.1 21.0 3.8 7.8 6.2 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 tRNA_lig_CPD PF08302.11 CDI86588.1 - 3 7.2 15.1 3.5 7.0 4.8 2.1 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain DUF4175 PF13779.6 CDI86588.1 - 3.1 5.6 39.7 1.5 6.6 19.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) Rad54_N PF08658.10 CDI86588.1 - 3.1 7.9 10.1 8 6.6 1.4 2.1 2 0 0 2 2 2 0 Rad54 N terminal G0-G1_switch_2 PF15103.6 CDI86588.1 - 3.2 8.2 11.7 5.4 7.5 2.0 2.2 2 0 0 2 2 2 0 G0/G1 switch protein 2 tRNA_synt_1c_R2 PF04557.15 CDI86588.1 - 3.3 8.7 14.0 6.3 7.8 2.3 2.2 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Suf PF05843.14 CDI86588.1 - 3.8 7.4 22.7 1.7 8.5 7.3 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Trp_oprn_chp PF09534.10 CDI86588.1 - 4 7.2 6.9 8.4 6.1 6.9 1.5 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Sec62 PF03839.16 CDI86588.1 - 5.1 6.5 14.1 3.3 7.2 3.1 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 Calc_CGRP_IAPP PF00214.19 CDI86588.1 - 5.3 7.4 13.4 0.15 12.5 0.5 2.2 1 1 1 2 2 2 0 Calcitonin / CGRP / IAPP family Maf1 PF09174.10 CDI86588.1 - 6.9 6.8 9.5 5.8 7.0 1.0 2.1 2 0 0 2 2 2 0 Maf1 regulator NPR1_interact PF15699.5 CDI86588.1 - 7.8 7.2 19.8 6.4 7.5 5.4 2.2 2 0 0 2 2 2 0 NPR1 interacting Orf78 PF06024.12 CDI86588.1 - 8.4 6.8 11.1 14 6.0 1.7 2.2 2 0 0 2 2 2 0 Orf78 (ac78) DUF3306 PF11748.8 CDI86588.1 - 8.4 7.3 15.9 6.4 7.7 3.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) DUF3043 PF11241.8 CDI86588.1 - 8.6 6.4 11.7 8 6.5 1.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) DUF3381 PF11861.8 CDI86588.1 - 8.9 6.1 23.4 2.3 8.0 6.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) DUF4699 PF15770.5 CDI86589.1 - 1.1 8.9 9.7 1.4 8.6 9.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4699) Ion_trans PF00520.31 CDI86592.1 - 6e-13 48.6 6.9 2.8e-06 26.7 2.2 2.2 2 0 0 2 2 2 2 Ion transport protein UPF0176_N PF17773.1 CDI86593.1 - 1.2e-20 73.7 0.0 2.4e-20 72.7 0.0 1.6 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Methyltransf_3 PF01596.17 CDI86593.1 - 4.9e-17 61.8 0.0 2.9e-09 36.4 0.0 2.4 2 0 0 2 2 2 2 O-methyltransferase Rhodanese_C PF12368.8 CDI86593.1 - 8.9e-13 48.4 10.0 2e-12 47.3 10.0 1.6 1 0 0 1 1 1 1 Rhodanase C-terminal Rhodanese PF00581.20 CDI86593.1 - 5.4e-09 36.5 0.0 1.2e-08 35.5 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_24 PF13578.6 CDI86593.1 - 1.4e-08 35.7 0.1 2.5e-07 31.7 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain tRNA_Me_trans PF03054.16 CDI86594.1 - 2e-76 257.1 0.0 8.7e-70 235.3 0.0 2.5 2 1 0 2 2 2 2 tRNA methyl transferase SufE PF02657.15 CDI86594.1 - 0.0008 19.2 0.0 0.0033 17.2 0.0 2.1 2 0 0 2 2 2 1 Fe-S metabolism associated domain ThiI PF02568.14 CDI86594.1 - 0.018 14.6 0.0 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Presenilin PF01080.17 CDI86595.1 - 5.5 5.6 5.6 14 4.3 5.6 1.6 1 0 0 1 1 1 0 Presenilin Carb_anhydrase PF00194.21 CDI86596.1 - 8.8e-22 77.9 2.7 1.7e-13 50.7 0.0 2.9 2 1 0 2 2 2 2 Eukaryotic-type carbonic anhydrase SMC_ScpB PF04079.16 CDI86596.1 - 0.0085 15.7 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 Segregation and condensation complex subunit ScpB MFS_1 PF07690.16 CDI86597.1 - 2.1e-10 40.1 22.6 1.6e-07 30.6 24.4 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Spt20 PF12090.8 CDI86599.1 - 0.001 18.7 9.0 0.0013 18.4 9.0 1.3 1 0 0 1 1 1 1 Spt20 family Androgen_recep PF02166.16 CDI86599.1 - 0.23 10.2 10.2 0.27 10.0 10.2 1.1 1 0 0 1 1 1 0 Androgen receptor TFIIA PF03153.13 CDI86599.1 - 0.42 10.5 20.8 0.59 10.1 20.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI86599.1 - 0.81 9.8 5.5 1 9.5 5.5 1.2 1 0 0 1 1 1 0 DDHD domain Fer4_22 PF17179.4 CDI86599.1 - 1.3 9.9 8.8 1.9 9.4 7.1 2.0 1 1 1 2 2 2 0 4Fe-4S dicluster domain Neur_chan_memb PF02932.16 CDI86599.1 - 3.7 7.5 6.3 4.5 7.3 6.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CwfJ_C_2 PF04676.14 CDI86600.1 - 1.9e-19 70.4 0.1 2.8e-19 69.8 0.1 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Styelin PF17562.2 CDI86600.1 - 0.01 16.2 0.1 0.025 14.9 0.1 1.7 1 0 0 1 1 1 0 Styelin CwfJ_C_1 PF04677.15 CDI86600.1 - 0.047 13.6 0.1 0.074 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 SUIM_assoc PF16619.5 CDI86602.1 - 0.015 15.3 0.1 0.015 15.3 0.1 3.8 2 1 1 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 CDI86602.1 - 0.13 11.2 18.6 0.23 10.4 1.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Pellino PF04710.14 CDI86602.1 - 0.14 10.8 0.0 0.14 10.8 0.0 2.1 2 0 0 2 2 2 0 Pellino Spt20 PF12090.8 CDI86602.1 - 3.7 7.1 28.4 0.82 9.2 1.2 2.6 2 0 0 2 2 2 0 Spt20 family Macoilin PF09726.9 CDI86603.1 - 2.3e-05 23.2 19.2 2.3e-05 23.2 19.2 2.3 2 1 0 2 2 2 1 Macoilin family Pox_G5 PF04599.12 CDI86603.1 - 0.06 12.3 2.4 0.093 11.7 2.4 1.3 1 0 0 1 1 1 0 Poxvirus G5 protein Shadoo PF14999.6 CDI86603.1 - 0.093 12.8 12.1 0.24 11.5 12.1 1.7 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective Spt20 PF12090.8 CDI86604.1 - 0.0044 16.7 19.7 0.0044 16.7 19.7 1.2 1 0 0 1 1 1 1 Spt20 family AAT PF03417.16 CDI86604.1 - 0.012 15.3 12.6 0.013 15.2 12.6 1.0 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase HATPase_c_2 PF13581.6 CDI86604.1 - 0.016 15.2 7.3 0.02 14.8 7.3 1.2 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain RskA PF10099.9 CDI86604.1 - 0.017 15.4 20.4 0.021 15.1 20.4 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA FBP_C PF16571.5 CDI86604.1 - 0.063 12.8 5.7 0.076 12.5 5.7 1.2 1 0 0 1 1 1 0 FBP C-terminal treble-clef zinc-finger TraT PF05818.12 CDI86604.1 - 0.076 12.7 12.5 0.085 12.5 12.5 1.0 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein SprA-related PF12118.8 CDI86604.1 - 0.13 11.4 26.1 0.14 11.2 26.1 1.1 1 0 0 1 1 1 0 SprA-related family Roughex PF06020.11 CDI86604.1 - 0.93 8.5 10.7 0.96 8.5 10.7 1.1 1 0 0 1 1 1 0 Drosophila roughex protein TERB2 PF15101.6 CDI86604.1 - 2.8 7.9 13.9 2.8 7.9 13.9 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Ctr PF04145.15 CDI86604.1 - 2.9 8.5 6.8 3.1 8.4 6.8 1.1 1 0 0 1 1 1 0 Ctr copper transporter family EOS1 PF12326.8 CDI86604.1 - 3.8 7.4 7.0 4 7.3 7.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein TFIIA PF03153.13 CDI86604.1 - 6.1 6.7 32.6 6.2 6.7 32.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI86605.1 - 0.017 14.7 6.1 0.021 14.5 6.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI86605.1 - 0.045 14.4 5.2 0.056 14.1 5.2 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF5521 PF17659.1 CDI86605.1 - 0.1 10.4 3.8 0.1 10.4 3.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5521) DUF1180 PF06679.12 CDI86605.1 - 0.15 12.5 5.5 0.16 12.4 5.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) CDK2AP PF09806.9 CDI86605.1 - 0.27 11.3 9.7 0.31 11.1 9.7 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein PIP5K PF01504.18 CDI86605.1 - 0.31 10.2 3.0 0.36 10.0 3.0 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Androgen_recep PF02166.16 CDI86605.1 - 0.48 9.2 12.8 0.53 9.1 12.8 1.1 1 0 0 1 1 1 0 Androgen receptor CSG2 PF16965.5 CDI86605.1 - 0.96 8.3 2.7 1.1 8.2 2.7 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Spt20 PF12090.8 CDI86605.1 - 1.1 8.8 18.1 1.4 8.5 18.1 1.1 1 0 0 1 1 1 0 Spt20 family Coilin_N PF15862.5 CDI86605.1 - 2.7 7.8 8.6 3.3 7.5 8.6 1.1 1 0 0 1 1 1 0 Coilin N-terminus TFIIA PF03153.13 CDI86605.1 - 2.9 7.8 16.9 3.1 7.7 16.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CDI86605.1 - 3 8.5 17.3 3.4 8.3 17.3 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 CDI86605.1 - 6.2 5.5 8.6 6.9 5.3 8.6 1.0 1 0 0 1 1 1 0 Presenilin TFIID_20kDa PF03847.13 CDI86606.1 - 0.021 15.3 0.0 0.032 14.7 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A CENP-T_C PF15511.6 CDI86606.1 - 0.057 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDI86606.1 - 0.13 12.7 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 CENP-S protein RskA PF10099.9 CDI86607.1 - 0.001 19.4 7.4 0.001 19.4 7.4 8.4 1 1 5 6 6 6 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI86608.1 - 0.0033 17.1 18.8 0.0033 17.1 18.8 3.9 2 2 1 3 3 3 1 Nuclear RNA-splicing-associated protein RAP1 PF07218.11 CDI86608.1 - 0.095 11.0 11.4 0.51 8.6 2.7 2.2 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) AWPM-19 PF05512.11 CDI86608.1 - 0.42 10.8 0.0 0.42 10.8 0.0 3.6 4 0 0 4 4 4 0 AWPM-19-like family SR-25 PF10500.9 CDI86609.1 - 6.1e-05 22.7 3.0 6.1e-05 22.7 3.0 3.2 3 0 0 3 3 3 2 Nuclear RNA-splicing-associated protein PigN PF04987.14 CDI86609.1 - 0.16 10.8 1.2 0.4 9.5 1.2 1.6 2 0 0 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) Het-C PF07217.11 CDI86609.1 - 0.16 10.4 4.2 0.22 10.0 4.2 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Peroxin-13_N PF04088.13 CDI86609.1 - 0.19 12.0 6.3 0.12 12.6 4.3 1.6 2 0 0 2 2 1 0 Peroxin 13, N-terminal region DUF913 PF06025.12 CDI86609.1 - 0.2 10.6 5.9 0.083 11.9 2.0 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Connexin PF00029.19 CDI86609.1 - 0.25 11.1 8.9 0.35 10.6 8.9 1.2 1 0 0 1 1 1 0 Connexin SID-1_RNA_chan PF13965.6 CDI86609.1 - 0.25 9.7 1.8 0.29 9.5 1.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 FAM176 PF14851.6 CDI86609.1 - 0.28 10.9 5.4 0.57 9.8 5.4 1.5 1 0 0 1 1 1 0 FAM176 family eIF-3_zeta PF05091.12 CDI86609.1 - 0.45 9.4 16.8 0.62 9.0 16.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2126 PF09899.9 CDI86609.1 - 0.52 8.3 6.0 0.72 7.9 6.0 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Pal1 PF08316.11 CDI86609.1 - 0.63 10.8 6.7 0.29 11.9 3.9 1.9 2 0 0 2 2 2 0 Pal1 cell morphology protein CLN3 PF02487.17 CDI86609.1 - 0.72 8.8 7.3 1.1 8.2 7.3 1.2 1 0 0 1 1 1 0 CLN3 protein CSG2 PF16965.5 CDI86609.1 - 0.72 8.7 4.2 1.3 7.9 4.2 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator CPSF100_C PF13299.6 CDI86609.1 - 0.83 9.8 11.4 0.61 10.2 9.1 1.8 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF2367 PF10164.9 CDI86609.1 - 0.95 10.0 8.7 3.5 8.2 8.7 2.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) Gti1_Pac2 PF09729.9 CDI86609.1 - 1.1 9.3 13.7 1.3 9.1 9.0 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family CobT PF06213.12 CDI86609.1 - 1.3 8.3 21.7 3.1 7.1 21.7 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SpoIIP PF07454.11 CDI86609.1 - 1.6 8.1 15.5 2.6 7.4 15.5 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) EIIBC-GUT_N PF03612.14 CDI86609.1 - 1.9 8.2 12.9 2.6 7.8 11.1 1.9 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Sec62 PF03839.16 CDI86609.1 - 2 7.8 8.1 3 7.3 8.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 PIP5K PF01504.18 CDI86609.1 - 2.2 7.5 12.7 0.31 10.2 8.8 1.5 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Ureide_permease PF07168.11 CDI86609.1 - 2.4 6.8 4.6 3.6 6.2 4.6 1.2 1 0 0 1 1 1 0 Ureide permease SLC12 PF03522.15 CDI86609.1 - 2.4 7.1 14.3 4.4 6.2 14.3 1.3 1 0 0 1 1 1 0 Solute carrier family 12 WBP-1 PF11669.8 CDI86609.1 - 6.4 7.5 15.9 35 5.1 15.8 2.3 1 1 0 1 1 1 0 WW domain-binding protein 1 RR_TM4-6 PF06459.12 CDI86609.1 - 6.4 6.5 15.5 11 5.8 15.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4770 PF15994.5 CDI86609.1 - 6.5 7.0 14.4 11 6.2 14.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) G0-G1_switch_2 PF15103.6 CDI86609.1 - 6.9 7.2 9.2 14 6.2 9.2 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 FHIPEP PF00771.20 CDI86609.1 - 8.7 4.7 7.7 12 4.2 7.7 1.1 1 0 0 1 1 1 0 FHIPEP family V_ATPase_I PF01496.19 CDI86609.1 - 8.8 4.1 16.9 12 3.7 16.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spt20 PF12090.8 CDI86609.1 - 9.6 5.7 44.4 0.62 9.6 39.0 1.7 2 0 0 2 2 2 0 Spt20 family Exonuc_VII_L PF02601.15 CDI86610.1 - 9.6e-06 25.4 0.0 9.6e-06 25.4 0.0 4.8 4 1 1 5 5 5 2 Exonuclease VII, large subunit RskA PF10099.9 CDI86610.1 - 0.0017 18.7 14.4 0.0017 18.7 14.4 10.4 2 1 4 6 6 6 2 Anti-sigma-K factor rskA Macoilin PF09726.9 CDI86611.1 - 1.7 7.1 43.5 2 6.9 43.5 1.0 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 CDI86611.1 - 8.5 6.2 37.5 11 5.9 37.5 1.0 1 0 0 1 1 1 0 SPX domain NPR3 PF03666.13 CDI86613.1 - 0.01 14.7 24.9 0.011 14.5 24.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Endostatin PF06482.11 CDI86613.1 - 0.017 14.6 24.4 0.018 14.5 24.4 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin FAM60A PF15396.6 CDI86613.1 - 0.03 14.3 18.3 0.035 14.1 18.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF3807 PF12720.7 CDI86613.1 - 0.14 12.4 34.5 0.17 12.1 34.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Senescence_reg PF04520.13 CDI86613.1 - 0.43 11.4 18.7 0.67 10.8 18.7 1.3 1 0 0 1 1 1 0 Senescence regulator Presenilin PF01080.17 CDI86613.1 - 0.66 8.7 37.1 0.76 8.5 37.1 1.0 1 0 0 1 1 1 0 Presenilin NARP1 PF12569.8 CDI86613.1 - 0.82 8.5 24.9 1.1 8.1 24.9 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF966 PF06136.13 CDI86613.1 - 0.87 9.2 25.1 0.91 9.2 25.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Hamartin PF04388.12 CDI86613.1 - 0.91 8.1 25.1 0.99 8.0 25.1 1.0 1 0 0 1 1 1 0 Hamartin protein Myc_N PF01056.18 CDI86613.1 - 0.97 9.3 20.2 1.2 8.9 20.2 1.1 1 0 0 1 1 1 0 Myc amino-terminal region TFIIA PF03153.13 CDI86613.1 - 0.99 9.3 56.6 1.4 8.8 56.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1387 PF07139.11 CDI86613.1 - 1.4 8.5 30.6 1.7 8.3 30.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Dsh_C PF12316.8 CDI86613.1 - 1.6 9.1 15.6 1.9 8.8 15.6 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal SLC12 PF03522.15 CDI86613.1 - 2 7.3 31.4 2.3 7.1 31.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 MTBP_C PF14920.6 CDI86613.1 - 2.1 8.0 21.5 2.5 7.8 21.5 1.2 1 0 0 1 1 1 0 MDM2-binding DUF4050 PF13259.6 CDI86613.1 - 2.1 8.6 27.0 3.2 8.0 27.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) DUF4045 PF13254.6 CDI86613.1 - 2.2 7.8 28.9 2.6 7.6 28.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Hydin_ADK PF17213.3 CDI86613.1 - 2.4 8.4 23.0 3.2 8.0 23.0 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF2126 PF09899.9 CDI86613.1 - 2.8 5.9 17.0 3.3 5.7 17.0 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Raftlin PF15250.6 CDI86613.1 - 3.1 6.5 25.5 3.8 6.1 25.5 1.0 1 0 0 1 1 1 0 Raftlin Nha1_C PF08619.10 CDI86613.1 - 3.6 6.7 34.0 4.1 6.5 34.0 1.0 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus GREB1 PF15782.5 CDI86613.1 - 4.1 4.4 26.8 4.7 4.2 26.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4569 PF15133.6 CDI86613.1 - 4.2 7.0 25.9 5.3 6.7 25.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Lin-8 PF03353.15 CDI86613.1 - 6.7 6.2 36.5 8.1 5.9 36.5 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist FCP1_C PF09309.10 CDI86613.1 - 7.3 6.4 27.0 9.2 6.1 27.0 1.2 1 0 0 1 1 1 0 FCP1, C-terminal UPF0560 PF10577.9 CDI86613.1 - 8.1 4.8 33.2 11 4.4 33.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 CDK5_activator PF03261.15 CDI86613.1 - 8.1 5.9 23.0 9.1 5.7 23.0 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Mitofilin PF09731.9 CDI86613.1 - 8.3 5.1 38.0 9.9 4.9 38.0 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Mem_trans PF03547.18 CDI86613.1 - 8.4 4.7 12.8 8.6 4.6 12.8 1.1 1 0 0 1 1 1 0 Membrane transport protein BAF1_ABF1 PF04684.13 CDI86613.1 - 9 5.2 27.2 10 5.1 27.2 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CAML PF14963.6 CDI86613.1 - 9.3 6.3 15.6 11 6.0 15.6 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand CCSAP PF15748.5 CDI86613.1 - 9.9 6.2 35.0 12 6.0 35.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Band_3_cyto PF07565.13 CDI86613.1 - 10 5.9 27.0 15 5.3 27.0 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RskA PF10099.9 CDI86614.1 - 7.4e-09 36.2 4.3 8.1e-05 23.0 0.0 2.2 1 1 1 2 2 2 2 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI86614.1 - 0.00012 21.7 57.7 0.0047 16.6 28.7 2.2 2 0 0 2 2 2 2 Spt20 family DUF2722 PF10846.8 CDI86614.1 - 0.00013 21.0 42.9 0.0077 15.2 21.8 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) Sporozoite_P67 PF05642.11 CDI86614.1 - 0.00094 17.4 3.3 0.00094 17.4 3.3 1.6 2 0 0 2 2 2 1 Sporozoite P67 surface antigen Med15 PF09606.10 CDI86614.1 - 0.0069 15.1 42.7 0.013 14.2 20.4 2.1 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal V_ATPase_I PF01496.19 CDI86614.1 - 0.032 12.2 12.2 0.28 9.0 5.1 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF4834 PF16118.5 CDI86614.1 - 0.045 14.7 0.3 0.045 14.7 0.3 3.4 4 0 0 4 4 3 0 Domain of unknown function (DUF4834) Spore_YhcN_YlaJ PF09580.10 CDI86614.1 - 0.07 13.2 11.7 0.27 11.3 11.7 1.8 1 1 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) eIF-3_zeta PF05091.12 CDI86614.1 - 0.082 11.9 23.7 0.5 9.3 10.6 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Cwf_Cwc_15 PF04889.12 CDI86614.1 - 0.11 12.3 16.8 0.065 13.0 7.0 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DcuA_DcuB PF03605.14 CDI86614.1 - 0.13 11.2 0.3 0.93 8.3 0.1 2.0 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Lin-8 PF03353.15 CDI86614.1 - 0.19 11.3 27.2 0.076 12.6 13.8 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Connexin PF00029.19 CDI86614.1 - 0.28 10.9 10.1 0.95 9.2 4.2 2.2 2 0 0 2 2 2 0 Connexin OSTbeta PF15048.6 CDI86614.1 - 0.35 11.0 7.6 0.059 13.5 2.0 2.2 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein FHIPEP PF00771.20 CDI86614.1 - 0.53 8.7 7.6 3.3 6.1 2.8 2.1 2 0 0 2 2 2 0 FHIPEP family HA2 PF04408.23 CDI86614.1 - 0.67 10.3 9.5 2.9 8.2 2.0 2.6 2 1 0 2 2 2 0 Helicase associated domain (HA2) DUF533 PF04391.12 CDI86614.1 - 1 8.9 15.3 0.91 9.1 4.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF533) Presenilin PF01080.17 CDI86614.1 - 1.1 8.0 31.4 0.099 11.4 1.7 2.1 1 1 0 2 2 2 0 Presenilin Spore_coat_CotO PF14153.6 CDI86614.1 - 1.5 8.7 24.4 0.93 9.4 9.7 2.3 2 0 0 2 2 2 0 Spore coat protein CotO LTV PF04180.14 CDI86614.1 - 1.5 8.5 15.7 2.5 7.8 8.4 2.1 2 0 0 2 2 2 0 Low temperature viability protein RPA43_OB PF17875.1 CDI86614.1 - 2 9.0 11.8 5.2 7.7 3.0 2.5 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Rpp20 PF12328.8 CDI86614.1 - 2.1 8.3 13.2 11 5.9 6.7 2.5 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P RNase_H2_suC PF08615.11 CDI86614.1 - 3.8 7.7 13.4 63 3.7 13.3 2.1 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DUF2072 PF09845.9 CDI86614.1 - 4.3 7.6 12.3 8.9 6.6 2.8 2.3 2 0 0 2 2 2 0 Zn-ribbon containing protein DUF2362 PF10154.9 CDI86614.1 - 4.4 6.1 22.2 5.8 5.7 22.2 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) Peptidase_S49_N PF08496.10 CDI86614.1 - 4.6 7.3 16.9 2.1 8.4 7.6 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Folate_carrier PF01770.18 CDI86614.1 - 5 5.8 7.0 9.3 4.9 3.1 2.1 2 0 0 2 2 2 0 Reduced folate carrier TFB6 PF17110.5 CDI86614.1 - 6.6 6.4 10.6 4.1 7.1 2.9 2.7 3 0 0 3 3 3 0 Subunit 11 of the general transcription factor TFIIH DUF2407 PF10302.9 CDI86614.1 - 7.5 7.2 12.3 4.7 7.8 0.4 2.6 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain RR_TM4-6 PF06459.12 CDI86614.1 - 8.3 6.1 17.0 5.8 6.7 7.3 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RAP1 PF07218.11 CDI86614.1 - 8.5 4.5 12.4 12 4.0 12.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4746 PF15928.5 CDI86614.1 - 9.3 5.6 10.5 5.2 6.4 3.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) RP-C_C PF11800.8 CDI86615.1 - 0.045 13.9 0.3 0.05 13.7 0.3 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Tma16 PF11176.8 CDI86615.1 - 0.13 12.1 8.7 0.18 11.7 8.7 1.1 1 0 0 1 1 1 0 Translation machinery-associated protein 16 Paf1 PF03985.13 CDI86615.1 - 8 5.3 20.2 12 4.8 20.2 1.2 1 0 0 1 1 1 0 Paf1 MetallophosC PF16370.5 CDI86616.1 - 0.13 12.5 0.4 0.28 11.4 0.4 1.5 1 0 0 1 1 1 0 C terminal of Calcineurin-like phosphoesterase SPX PF03105.19 CDI86617.1 - 2.5 7.9 6.3 3.6 7.4 6.1 1.4 1 1 0 1 1 1 0 SPX domain Ank_2 PF12796.7 CDI86618.1 - 5.8e-12 46.0 0.0 4.4e-06 27.2 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 CDI86618.1 - 1.7e-11 44.0 0.4 0.0086 16.5 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 CDI86618.1 - 4.7e-11 43.0 0.0 1.2e-06 29.0 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDI86618.1 - 1.7e-09 37.7 0.0 6.6e-06 26.3 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI86618.1 - 3.9e-08 32.9 0.1 0.038 14.5 0.0 3.5 3 1 0 3 3 3 2 Ankyrin repeat AFP PF02420.15 CDI86618.1 - 0.89 10.1 4.8 2.5 8.7 4.8 1.8 1 0 0 1 1 1 0 Insect antifreeze protein repeat CCSAP PF15748.5 CDI86620.1 - 8.3 6.5 28.2 9.5 6.3 28.2 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SR-25 PF10500.9 CDI86622.1 - 0.0019 17.9 77.5 0.012 15.3 3.4 4.2 2 2 0 3 3 3 2 Nuclear RNA-splicing-associated protein DUF572 PF04502.13 CDI86622.1 - 0.21 11.1 31.7 2.6 7.6 12.7 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF572) DUF4207 PF13904.6 CDI86622.1 - 4.3 7.0 59.3 0.46 10.1 11.2 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4207) SARAF PF06682.12 CDI86622.1 - 6 6.4 42.6 0.12 12.0 32.1 3.0 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Secretin_N_2 PF07655.13 CDI86623.1 - 0.0012 19.3 45.1 0.053 14.1 10.5 3.2 3 0 0 3 3 3 3 Secretin N-terminal domain DUF4171 PF13775.6 CDI86623.1 - 0.072 13.5 0.3 0.072 13.5 0.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4171) DUF4614 PF15391.6 CDI86623.1 - 0.82 9.6 32.2 1.8 8.5 0.5 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4614) Miga PF10265.9 CDI86623.1 - 2.1 7.2 16.5 5.8 5.8 16.7 1.3 1 1 0 1 1 1 0 Mitoguardin SPX PF03105.19 CDI86623.1 - 3.4 7.5 30.7 7.4 6.4 30.8 1.4 1 1 0 1 1 1 0 SPX domain SR-25 PF10500.9 CDI86623.1 - 6.2 6.4 70.4 0.97 9.0 12.4 3.2 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein FAM76 PF16046.5 CDI86624.1 - 0.018 14.4 13.3 0.021 14.2 13.3 1.0 1 0 0 1 1 1 0 FAM76 protein Spt20 PF12090.8 CDI86624.1 - 0.45 10.1 44.7 0.024 14.3 11.7 2.0 2 0 0 2 2 2 0 Spt20 family RskA PF10099.9 CDI86624.1 - 2.5 8.4 33.9 0.56 10.5 21.6 2.0 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Vps54 PF07928.12 CDI86625.1 - 7.8e-14 52.3 5.4 7.8e-14 52.3 5.4 9.4 10 1 1 11 11 11 1 Vps54-like protein RskA PF10099.9 CDI86625.1 - 0.00075 19.8 0.0 0.00075 19.8 0.0 18.2 4 3 7 13 13 13 2 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI86625.1 - 0.0025 17.8 1.9 0.0025 17.8 1.9 20.5 10 7 3 13 13 13 1 Unstructured region C-term to UIM in Ataxin3 PAP1 PF08601.10 CDI86625.1 - 0.06 13.1 0.0 0.06 13.1 0.0 10.3 6 3 2 9 9 9 0 Transcription factor PAP1 Apt1 PF10351.9 CDI86626.1 - 1.6 7.5 26.8 2.2 7.1 26.8 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain RPN2_C PF18004.1 CDI86627.1 - 0.56 10.1 18.4 0.69 9.8 18.4 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain TRAP_alpha PF03896.16 CDI86627.1 - 0.98 8.6 10.5 1.1 8.4 10.5 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RR_TM4-6 PF06459.12 CDI86627.1 - 0.99 9.2 23.2 1.1 9.0 23.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Connexin PF00029.19 CDI86627.1 - 1 9.1 19.2 1.2 8.9 19.2 1.0 1 0 0 1 1 1 0 Connexin Afi1 PF07792.12 CDI86627.1 - 1.4 9.4 21.5 1.5 9.3 21.5 1.0 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF913 PF06025.12 CDI86627.1 - 1.4 7.8 15.5 1.4 7.8 15.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF5523 PF17661.1 CDI86627.1 - 1.9 8.1 22.5 2.4 7.8 22.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) PBP1_TM PF14812.6 CDI86627.1 - 2.5 8.5 9.8 3.4 8.1 9.8 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ureide_permease PF07168.11 CDI86627.1 - 3.1 6.4 12.0 3.2 6.4 12.0 1.0 1 0 0 1 1 1 0 Ureide permease CPSF100_C PF13299.6 CDI86627.1 - 3.2 7.9 20.1 3.8 7.7 20.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2828 PF11443.8 CDI86627.1 - 3.3 5.7 24.0 3.7 5.5 24.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4366 PF14283.6 CDI86627.1 - 3.6 7.6 11.7 4.3 7.4 11.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF1764 PF08576.10 CDI86627.1 - 3.7 8.5 20.1 5.7 7.9 20.1 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) SpoIIP PF07454.11 CDI86627.1 - 3.9 6.9 26.4 4.4 6.7 26.4 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CLN3 PF02487.17 CDI86627.1 - 4.3 6.3 20.2 4.5 6.2 20.2 1.0 1 0 0 1 1 1 0 CLN3 protein FAM60A PF15396.6 CDI86627.1 - 4.4 7.2 19.7 5 7.1 19.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF789 PF05623.12 CDI86627.1 - 4.8 6.8 19.6 5.1 6.7 19.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF789) FAM176 PF14851.6 CDI86627.1 - 5.3 6.7 15.6 6.9 6.3 15.6 1.2 1 0 0 1 1 1 0 FAM176 family Endostatin PF06482.11 CDI86627.1 - 5.7 6.3 24.2 6.4 6.1 24.2 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin TYW3 PF02676.14 CDI86627.1 - 5.9 6.2 14.3 6.6 6.0 14.3 1.0 1 0 0 1 1 1 0 Methyltransferase TYW3 NPR3 PF03666.13 CDI86627.1 - 6.1 5.5 23.5 6.9 5.3 23.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Tim54 PF11711.8 CDI86627.1 - 6.3 5.5 21.7 7.1 5.3 21.7 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Gti1_Pac2 PF09729.9 CDI86627.1 - 6.4 6.8 22.5 7.3 6.6 22.5 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family PIP5K PF01504.18 CDI86627.1 - 6.4 5.9 22.9 7.2 5.7 22.9 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase CCDC53 PF10152.9 CDI86627.1 - 8 6.9 26.3 9.9 6.6 26.3 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex SpoVR PF04293.13 CDI86627.1 - 8.2 5.0 20.1 9 4.9 20.1 1.0 1 0 0 1 1 1 0 SpoVR like protein EFTUD2 PF16004.5 CDI86627.1 - 8.9 6.9 25.5 12 6.6 25.5 1.2 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus NARP1 PF12569.8 CDI86627.1 - 9.8 5.0 23.9 11 4.7 23.9 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Band_3_cyto PF07565.13 CDI86627.1 - 9.9 5.9 26.6 12 5.6 26.6 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Presenilin PF01080.17 CDI86627.1 - 9.9 4.8 31.5 12 4.6 31.5 1.0 1 0 0 1 1 1 0 Presenilin CSG2 PF16965.5 CDI86627.1 - 10 5.0 16.2 10 4.9 16.2 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator UTP25 PF06862.12 CDI86628.1 - 1.6e-10 40.4 4.7 0.00014 20.8 0.0 2.4 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 TFIIA PF03153.13 CDI86628.1 - 5.9e-05 23.3 40.6 8.1e-05 22.8 40.6 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI86628.1 - 0.00086 18.4 12.8 0.00086 18.4 12.8 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) EPL1 PF10513.9 CDI86628.1 - 0.0038 17.6 25.4 0.092 13.1 6.8 2.4 2 0 0 2 2 2 2 Enhancer of polycomb-like SpoIIP PF07454.11 CDI86628.1 - 0.0056 16.2 17.9 0.02 14.4 5.4 2.2 2 0 0 2 2 2 2 Stage II sporulation protein P (SpoIIP) DUF913 PF06025.12 CDI86628.1 - 0.051 12.6 24.6 0.15 11.0 7.5 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Zip PF02535.22 CDI86628.1 - 0.57 9.3 24.4 0.53 9.4 4.4 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter DUF2235 PF09994.9 CDI86628.1 - 0.83 8.9 12.5 2.1 7.6 12.5 1.7 1 1 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) Striatin PF08232.12 CDI86628.1 - 0.99 10.0 30.5 0.66 10.6 10.9 2.5 2 0 0 2 2 2 0 Striatin family SLC12 PF03522.15 CDI86628.1 - 3 6.8 29.0 0.33 9.9 8.5 2.1 2 0 0 2 2 2 0 Solute carrier family 12 NPR3 PF03666.13 CDI86628.1 - 3.7 6.2 34.5 0.62 8.8 6.2 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 N6_N4_Mtase PF01555.18 CDI86628.1 - 4.3 7.0 10.4 0.033 13.9 2.2 1.6 2 0 0 2 2 2 0 DNA methylase Gti1_Pac2 PF09729.9 CDI86628.1 - 4.5 7.3 33.3 0.15 12.1 4.9 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family Afi1 PF07792.12 CDI86628.1 - 5.2 7.6 24.2 1.7 9.1 7.8 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MCU PF04678.13 CDI86628.1 - 5.4 7.1 10.2 12 5.9 10.2 1.6 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF572 PF04502.13 CDI86628.1 - 8 6.0 34.9 0.72 9.4 10.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) Nha1_C PF08619.10 CDI86628.1 - 8.2 5.5 38.9 0.052 12.8 13.6 2.3 2 0 0 2 2 2 0 Alkali metal cation/H+ antiporter Nha1 C terminus WBP-1 PF11669.8 CDI86628.1 - 9.7 6.9 8.8 15 6.3 4.6 2.6 2 1 0 2 2 2 0 WW domain-binding protein 1 ArfGap PF01412.18 CDI86630.1 - 1.8e-23 82.8 0.2 5.1e-23 81.4 0.0 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Topoisom_bac PF01131.20 CDI86630.1 - 5.6e-08 32.2 0.0 8.4e-08 31.6 0.0 1.3 1 0 0 1 1 1 1 DNA topoisomerase SUIM_assoc PF16619.5 CDI86630.1 - 0.0018 18.3 7.8 0.25 11.4 0.3 2.7 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI86630.1 - 1.8 8.4 19.9 3 7.7 19.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI86630.1 - 2.6 6.5 6.8 3.7 6.0 6.8 1.3 1 0 0 1 1 1 0 Macoilin family LRRFIP PF09738.9 CDI86630.1 - 8.2 5.8 10.2 1 8.7 3.5 2.0 2 0 0 2 2 2 0 LRRFIP family Hydrolase PF00702.26 CDI86631.1 - 4.1e-16 59.9 0.0 0.00013 22.4 0.0 4.0 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CDI86631.1 - 1.9e-14 53.6 27.3 2.6e-07 30.3 0.3 3.8 3 1 1 4 4 4 3 E1-E2 ATPase HMA PF00403.26 CDI86631.1 - 2.5e-09 37.5 0.0 4.5e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain Zea_mays_MuDR PF05928.11 CDI86631.1 - 0.017 14.7 0.2 0.046 13.4 0.2 1.6 1 0 0 1 1 1 0 Zea mays MURB-like protein (MuDR) Hydrolase_3 PF08282.12 CDI86631.1 - 0.18 11.5 0.0 3.3 7.4 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase SP_C-Propep PF08999.10 CDI86631.1 - 8.1 6.3 7.1 3.9 7.3 0.0 3.4 4 0 0 4 4 4 0 Surfactant protein C, N terminal propeptide COX2_TM PF02790.15 CDI86632.1 - 0.007 16.5 5.1 0.034 14.3 1.2 3.3 3 0 0 3 3 3 1 Cytochrome C oxidase subunit II, transmembrane domain Virul_fac_BrkB PF03631.15 CDI86632.1 - 0.017 14.7 1.1 0.017 14.7 1.1 3.2 4 0 0 4 4 4 0 Virulence factor BrkB Phage_Coat_B PF05356.11 CDI86632.1 - 0.031 14.2 0.6 6.5 6.7 0.1 3.4 2 0 0 2 2 2 0 Phage Coat protein B DUF4064 PF13273.6 CDI86632.1 - 0.047 14.0 6.5 3.2 8.1 1.3 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) PalH PF08733.10 CDI86632.1 - 0.5 9.3 4.3 5.4 5.9 0.3 2.9 3 0 0 3 3 3 0 PalH/RIM21 Abhydrolase_6 PF12697.7 CDI86633.1 - 1.2e-24 88.2 0.4 2e-24 87.5 0.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDI86633.1 - 6.2e-08 32.6 0.0 3.3e-07 30.2 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDI86633.1 - 1.6e-07 30.9 0.1 0.0031 16.8 0.1 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 PGAP1 PF07819.13 CDI86633.1 - 0.00061 19.6 0.0 0.00091 19.0 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Thioesterase PF00975.20 CDI86633.1 - 0.054 13.6 3.1 0.24 11.5 0.1 3.1 4 0 0 4 4 4 0 Thioesterase domain Abhydrolase_5 PF12695.7 CDI86633.1 - 0.063 13.0 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 CDI86633.1 - 0.064 13.1 0.5 0.12 12.2 0.5 1.4 1 0 0 1 1 1 0 Lipase (class 3) AAA_6 PF12774.7 CDI86634.1 - 2.5e-141 470.4 0.1 1.1e-139 465.0 0.0 2.7 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region AAA_8 PF12780.7 CDI86634.1 - 1.1e-90 303.4 0.0 2.5e-90 302.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 DHC_N2 PF08393.13 CDI86634.1 - 1.1e-82 278.3 11.1 1.1e-82 278.3 11.1 4.6 3 2 2 5 5 5 1 Dynein heavy chain, N-terminal region 2 MT PF12777.7 CDI86634.1 - 2.8e-78 263.4 13.9 6.8e-78 262.1 13.9 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_C PF18199.1 CDI86634.1 - 9.3e-54 182.7 5.3 7.6e-51 173.1 0.1 4.5 3 1 1 4 4 4 2 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 CDI86634.1 - 1.4e-47 161.6 0.0 3.1e-47 160.4 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_7 PF12775.7 CDI86634.1 - 4.6e-37 127.3 5.0 5.6e-29 100.9 0.3 4.8 4 1 1 5 5 5 3 P-loop containing dynein motor region AAA_9 PF12781.7 CDI86634.1 - 1.7e-26 92.7 9.4 2.4e-15 56.3 0.1 4.0 2 1 1 3 3 3 3 ATP-binding dynein motor region Dynein_AAA_lid PF17852.1 CDI86634.1 - 2.1e-20 73.1 1.5 2.6e-19 69.6 0.6 3.0 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 CDI86634.1 - 1.6e-19 70.3 0.0 2.6e-10 40.5 0.0 6.0 5 1 0 5 5 5 2 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 CDI86634.1 - 1.4e-08 34.9 0.1 1.2e-05 25.3 0.0 3.5 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain TIG PF01833.24 CDI86634.1 - 8e-07 29.0 0.1 2.5e-06 27.5 0.1 1.8 1 0 0 1 1 1 1 IPT/TIG domain Kelch_5 PF13854.6 CDI86634.1 - 3.6e-05 23.6 0.1 0.72 9.9 0.0 3.7 3 0 0 3 3 3 2 Kelch motif AAA_18 PF13238.6 CDI86634.1 - 9e-05 23.0 0.0 0.65 10.6 0.0 3.6 3 0 0 3 3 2 2 AAA domain AAA_lid_1 PF17857.1 CDI86634.1 - 0.00016 21.9 0.0 0.0016 18.6 0.0 2.6 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 CDI86634.1 - 0.00028 21.3 0.9 13 6.1 0.0 5.4 5 0 0 5 5 4 0 AAA ATPase domain AAA PF00004.29 CDI86634.1 - 0.0012 19.3 0.0 0.35 11.3 0.0 3.3 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Kelch_6 PF13964.6 CDI86634.1 - 0.029 14.7 0.0 5 7.6 0.0 3.1 3 0 0 3 3 2 0 Kelch motif AAA_30 PF13604.6 CDI86634.1 - 0.097 12.4 1.9 12 5.6 0.1 3.6 4 0 0 4 4 3 0 AAA domain RNA_helicase PF00910.22 CDI86634.1 - 0.097 13.1 0.2 15 6.1 0.0 3.3 3 0 0 3 3 3 0 RNA helicase AAA_33 PF13671.6 CDI86634.1 - 0.12 12.6 0.1 12 6.1 0.0 3.0 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 CDI86634.1 - 0.12 11.3 0.1 0.84 8.6 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 CDI86634.1 - 0.93 9.8 8.9 16 5.8 0.0 4.9 6 0 0 6 6 5 0 AAA domain Orbi_VP5 PF00901.17 CDI86634.1 - 3.5 5.9 6.6 0.23 9.8 0.8 1.9 2 0 0 2 2 2 0 Orbivirus outer capsid protein VP5 ClpS PF02617.17 CDI86635.1 - 0.066 13.0 0.6 0.066 13.0 0.6 1.7 2 0 0 2 2 2 0 ATP-dependent Clp protease adaptor protein ClpS RNA_pol_Rbc25 PF08292.12 CDI86635.1 - 0.12 12.6 1.6 0.79 10.0 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 ATP_bind_3 PF01171.20 CDI86636.1 - 8.8e-16 58.2 26.5 1.9e-07 31.0 6.2 5.1 3 1 2 5 5 5 4 PP-loop family Spt20 PF12090.8 CDI86636.1 - 0.0071 16.0 4.8 0.0071 16.0 4.8 7.1 5 2 1 6 6 6 2 Spt20 family Sin_N PF04801.13 CDI86636.1 - 0.069 12.4 0.0 0.069 12.4 0.0 4.8 2 2 2 4 4 4 0 Sin-like protein conserved region SAPS PF04499.15 CDI86636.1 - 1.1 8.0 32.2 0.4 9.4 11.9 3.2 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein RskA PF10099.9 CDI86637.1 - 0.046 14.0 0.0 0.046 14.0 0.0 24.9 7 5 10 17 17 17 0 Anti-sigma-K factor rskA RRM_Rrp7 PF17799.1 CDI86637.1 - 1.3 8.8 7.6 0.21 11.4 0.9 3.0 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain LANC_like PF05147.13 CDI86638.1 - 7.1e-05 21.5 0.0 7.1e-05 21.5 0.0 1.5 2 0 0 2 2 2 1 Lanthionine synthetase C-like protein DUF2828 PF11443.8 CDI86638.1 - 0.077 11.1 5.0 0.099 10.7 5.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Presenilin PF01080.17 CDI86638.1 - 0.096 11.4 11.1 0.13 11.0 11.1 1.2 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 CDI86638.1 - 0.098 11.7 3.9 0.13 11.3 3.9 1.1 1 0 0 1 1 1 0 CLN3 protein Zip PF02535.22 CDI86638.1 - 0.1 11.8 0.3 0.11 11.7 0.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Hid1 PF12722.7 CDI86638.1 - 0.16 10.1 9.0 0.19 9.8 9.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ABATE PF07336.11 CDI86638.1 - 0.19 12.4 12.9 0.31 11.7 12.9 1.3 1 0 0 1 1 1 0 Putative stress-induced transcription regulator MMR1 PF08505.10 CDI86638.1 - 0.21 11.9 13.1 0.29 11.4 13.1 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein PAT1 PF09770.9 CDI86638.1 - 0.21 9.8 16.7 0.23 9.7 16.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hydin_ADK PF17213.3 CDI86638.1 - 0.23 11.7 7.7 0.43 10.8 7.7 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain CCDC106 PF15794.5 CDI86638.1 - 0.25 11.1 11.3 0.36 10.5 11.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF1635 PF07795.11 CDI86638.1 - 0.33 10.8 15.1 0.54 10.1 15.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) TPP_enzyme_N PF02776.18 CDI86638.1 - 0.37 10.4 0.0 0.37 10.4 0.0 2.9 2 1 1 3 3 3 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain DivIC PF04977.15 CDI86638.1 - 0.45 10.3 17.0 1.4 8.7 3.0 2.3 2 0 0 2 2 2 0 Septum formation initiator CDC45 PF02724.14 CDI86638.1 - 0.69 8.1 9.3 0.91 7.7 9.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Sec62 PF03839.16 CDI86638.1 - 1.1 8.7 8.2 1.5 8.3 8.2 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 YABBY PF04690.13 CDI86638.1 - 1.1 9.8 8.0 1.6 9.3 8.0 1.2 1 0 0 1 1 1 0 YABBY protein Peroxin-3 PF04882.12 CDI86638.1 - 1.2 8.1 13.6 1.4 7.8 13.6 1.2 1 0 0 1 1 1 0 Peroxin-3 DUF45 PF01863.17 CDI86638.1 - 1.3 9.1 8.5 1.7 8.6 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF45 Neur_chan_memb PF02932.16 CDI86638.1 - 1.5 8.8 8.9 2.1 8.3 8.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EcsC PF12787.7 CDI86638.1 - 2 8.0 10.6 6.4 6.4 10.6 1.8 1 1 0 1 1 1 0 EcsC protein family Ndc1_Nup PF09531.10 CDI86638.1 - 3.2 6.3 10.3 3.5 6.2 10.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ALMT PF11744.8 CDI86638.1 - 3.7 6.3 10.3 4.5 6.0 10.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 CDI86638.1 - 3.8 6.4 12.5 4.9 6.1 12.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Mem_trans PF03547.18 CDI86638.1 - 4.7 5.5 4.7 6.3 5.1 4.7 1.1 1 0 0 1 1 1 0 Membrane transport protein FAM60A PF15396.6 CDI86638.1 - 6.2 6.8 10.4 9.5 6.2 10.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Membralin PF09746.9 CDI86638.1 - 8.8 5.3 7.8 11 4.9 7.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF1772 PF08592.11 CDI86640.1 - 0.0064 16.8 4.3 2.5 8.4 0.0 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF1772) BAF1_ABF1 PF04684.13 CDI86641.1 - 0.17 10.9 30.6 0.26 10.3 30.6 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor RR_TM4-6 PF06459.12 CDI86641.1 - 0.27 11.0 41.5 0.59 9.9 25.9 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 NPR3 PF03666.13 CDI86641.1 - 0.31 9.8 34.2 0.25 10.1 20.5 2.0 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Caldesmon PF02029.15 CDI86641.1 - 0.33 9.7 40.7 0.48 9.1 40.7 1.2 1 0 0 1 1 1 0 Caldesmon Hid1 PF12722.7 CDI86641.1 - 0.45 8.6 40.7 0.54 8.3 40.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Rtf2 PF04641.12 CDI86641.1 - 1.3 8.4 35.6 0.8 9.0 21.9 2.0 2 0 0 2 2 2 0 Rtf2 RING-finger RNA_pol_Rpc4 PF05132.14 CDI86641.1 - 1.8 9.0 31.7 4.3 7.7 17.8 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 EBP50_C PF09007.11 CDI86641.1 - 2.4 9.1 28.1 7.5 7.6 16.4 2.3 2 0 0 2 2 2 0 EBP50, C-terminal DUF2151 PF10221.9 CDI86641.1 - 4.7 5.7 24.6 5.7 5.4 24.6 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator PvlArgDC PF01862.16 CDI86641.1 - 6.1 6.6 8.6 7 6.4 3.7 2.3 2 0 0 2 2 2 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) DUF5427 PF10310.9 CDI86641.1 - 7 5.5 45.6 0.9 8.4 26.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5427) DUF2052 PF09747.9 CDI86641.1 - 7.1 6.7 44.0 5.6 7.1 6.7 2.0 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SDA1 PF05285.12 CDI86642.1 - 0.0018 17.8 12.2 0.0021 17.6 12.2 1.0 1 0 0 1 1 1 1 SDA1 TCP PF03634.13 CDI86642.1 - 0.006 17.2 26.9 0.0076 16.8 26.9 1.1 1 0 0 1 1 1 1 TCP family transcription factor Med26_M PF15694.5 CDI86642.1 - 0.091 12.8 33.2 0.12 12.5 33.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 26 middle domain Endostatin PF06482.11 CDI86642.1 - 0.093 12.2 24.0 0.12 11.8 24.0 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CCSAP PF15748.5 CDI86642.1 - 0.11 12.7 33.1 0.14 12.3 33.1 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PNISR PF15996.5 CDI86642.1 - 0.91 9.8 27.9 1.4 9.1 27.9 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF4407 PF14362.6 CDI86642.1 - 1 8.7 14.9 1.2 8.4 14.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Nop53 PF07767.11 CDI86642.1 - 1.1 8.6 25.9 1.4 8.2 25.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) eIF-3_zeta PF05091.12 CDI86642.1 - 1.4 7.9 26.5 1.7 7.5 26.5 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Smg8_Smg9 PF10220.9 CDI86642.1 - 1.4 7.1 21.8 1.7 6.9 21.8 1.0 1 0 0 1 1 1 0 Smg8_Smg9 DUF2828 PF11443.8 CDI86642.1 - 1.4 6.9 20.2 2.2 6.3 20.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CDK5_activator PF03261.15 CDI86642.1 - 1.5 8.3 20.8 1.9 8.0 20.8 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein CAC1F_C PF16885.5 CDI86642.1 - 1.5 8.4 21.4 1.9 8.1 21.4 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term PAT1 PF09770.9 CDI86642.1 - 2.1 6.5 39.3 2.5 6.3 39.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3332 PF11810.8 CDI86642.1 - 2.4 7.8 6.3 2.5 7.7 6.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) DUF1682 PF07946.14 CDI86642.1 - 2.4 7.3 11.4 2.6 7.2 11.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF3292 PF11696.8 CDI86642.1 - 3.2 6.0 17.6 4.6 5.5 17.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Exonuc_VII_L PF02601.15 CDI86642.1 - 3.4 7.2 19.8 3.5 7.1 19.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Innate_immun PF12782.7 CDI86642.1 - 3.6 7.0 24.1 3.7 7.0 24.1 1.2 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family LAP1C PF05609.12 CDI86642.1 - 7.8 5.5 29.2 9.3 5.2 29.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SUIM_assoc PF16619.5 CDI86643.1 - 0.012 15.7 9.8 0.012 15.7 9.8 3.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF3135 PF11333.8 CDI86643.1 - 0.042 14.1 0.2 0.042 14.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) Nop53 PF07767.11 CDI86643.1 - 0.12 11.8 14.8 0.23 10.8 14.8 1.5 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Draxin PF15550.6 CDI86643.1 - 3.6 7.4 22.6 0.15 11.9 8.6 2.1 2 0 0 2 2 2 0 Draxin TFIIA PF03153.13 CDI86644.1 - 2.1 8.2 6.7 2.5 8.0 6.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SOG2 PF10428.9 CDI86644.1 - 2.3 7.3 20.5 3.1 6.9 20.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein GREB1 PF15782.5 CDI86644.1 - 2.7 5.0 14.4 3.2 4.8 14.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 CDI86644.1 - 7.3 5.2 5.8 8.7 5.0 5.8 1.2 1 0 0 1 1 1 0 Presenilin SRP-alpha_N PF04086.13 CDI86644.1 - 8.9 6.1 14.1 10 5.9 14.1 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RskA PF10099.9 CDI86645.1 - 3.8e-06 27.3 0.0 3.8e-06 27.3 0.0 4.0 2 1 1 3 3 3 1 Anti-sigma-K factor rskA Peptidase_S49_N PF08496.10 CDI86645.1 - 0.018 15.1 3.4 0.018 15.1 3.4 3.2 3 0 0 3 3 3 0 Peptidase family S49 N-terminal RAP1 PF07218.11 CDI86645.1 - 0.82 7.9 11.8 0.91 7.7 11.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) V_ATPase_I PF01496.19 CDI86647.1 - 0.00087 17.4 15.9 0.00094 17.2 15.9 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family SURF6 PF04935.12 CDI86647.1 - 0.0023 17.7 18.6 0.0027 17.5 18.6 1.0 1 0 0 1 1 1 1 Surfeit locus protein 6 DUF4366 PF14283.6 CDI86647.1 - 0.0024 17.9 3.9 0.0025 17.9 3.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) PIP5K PF01504.18 CDI86647.1 - 0.0025 17.1 11.0 0.0027 17.0 11.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase SpoIIP PF07454.11 CDI86647.1 - 0.0037 16.8 14.7 0.0039 16.7 14.7 1.0 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 CDI86647.1 - 0.0042 16.9 11.6 0.0046 16.7 11.6 1.1 1 0 0 1 1 1 1 Connexin DUF913 PF06025.12 CDI86647.1 - 0.0075 15.3 10.0 0.0085 15.1 10.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) TRAP_alpha PF03896.16 CDI86647.1 - 0.0093 15.2 5.0 0.0095 15.2 5.0 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Pex14_N PF04695.13 CDI86647.1 - 0.0099 16.5 24.5 0.011 16.5 24.5 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 CDI86647.1 - 0.01 14.7 17.4 0.011 14.6 17.4 1.1 1 0 0 1 1 1 0 Presenilin CCDC53 PF10152.9 CDI86647.1 - 0.011 16.2 15.6 0.012 16.1 15.6 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Tim54 PF11711.8 CDI86647.1 - 0.017 13.9 12.7 0.018 13.9 12.7 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2828 PF11443.8 CDI86647.1 - 0.019 13.1 14.7 0.02 13.0 14.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MAP17 PF15807.5 CDI86647.1 - 0.02 15.1 6.9 0.025 14.8 6.9 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 PPL5 PF18168.1 CDI86647.1 - 0.02 14.2 11.1 0.024 14.0 11.1 1.0 1 0 0 1 1 1 0 Prim-pol family 5 DUF3408 PF11888.8 CDI86647.1 - 0.023 14.8 13.2 0.027 14.6 13.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DDHD PF02862.17 CDI86647.1 - 0.029 14.6 12.8 0.031 14.4 12.8 1.1 1 0 0 1 1 1 0 DDHD domain Afi1 PF07792.12 CDI86647.1 - 0.032 14.7 13.7 0.037 14.5 13.7 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking GNAT_acetyltr_2 PF13718.6 CDI86647.1 - 0.034 13.6 9.5 0.04 13.3 9.5 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 SLC12 PF03522.15 CDI86647.1 - 0.034 13.2 14.5 0.035 13.1 14.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 TERB2 PF15101.6 CDI86647.1 - 0.042 13.9 21.3 0.054 13.5 21.3 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CLN3 PF02487.17 CDI86647.1 - 0.05 12.7 12.3 0.05 12.6 12.3 1.0 1 0 0 1 1 1 0 CLN3 protein OATP PF03137.20 CDI86647.1 - 0.05 11.9 6.9 0.049 11.9 6.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF5327 PF17261.2 CDI86647.1 - 0.057 14.2 22.3 0.093 13.5 22.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5327) CSG2 PF16965.5 CDI86647.1 - 0.057 12.4 8.2 0.057 12.4 8.2 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator CPSF100_C PF13299.6 CDI86647.1 - 0.058 13.6 12.1 0.066 13.4 12.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal eIF-3_zeta PF05091.12 CDI86647.1 - 0.064 12.2 22.2 0.068 12.1 22.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GET2 PF08690.10 CDI86647.1 - 0.067 12.9 13.9 0.1 12.2 13.9 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 FAM176 PF14851.6 CDI86647.1 - 0.071 12.8 10.1 0.088 12.5 10.1 1.2 1 0 0 1 1 1 0 FAM176 family FemAB PF02388.16 CDI86647.1 - 0.072 12.0 13.5 0.076 11.9 13.5 1.0 1 0 0 1 1 1 0 FemAB family RR_TM4-6 PF06459.12 CDI86647.1 - 0.074 12.9 16.7 0.081 12.7 16.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3292 PF11696.8 CDI86647.1 - 0.084 11.2 10.1 0.094 11.1 10.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Serinc PF03348.15 CDI86647.1 - 0.091 11.7 9.5 0.093 11.6 9.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) EPL1 PF10513.9 CDI86647.1 - 0.091 13.1 16.9 0.13 12.7 16.9 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF5523 PF17661.1 CDI86647.1 - 0.095 12.4 16.3 0.1 12.2 16.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) TFIIA PF03153.13 CDI86647.1 - 0.1 12.5 43.0 0.12 12.3 43.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit eIF3_subunit PF08597.10 CDI86647.1 - 0.12 12.2 14.5 0.12 12.2 14.5 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Endostatin PF06482.11 CDI86647.1 - 0.13 11.7 16.2 0.14 11.6 16.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF1180 PF06679.12 CDI86647.1 - 0.14 12.6 4.0 0.15 12.5 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF2464 PF10240.9 CDI86647.1 - 0.14 11.7 11.1 0.15 11.6 11.1 1.0 1 0 0 1 1 1 0 Multivesicular body subunit 12 NPR3 PF03666.13 CDI86647.1 - 0.15 10.8 14.3 0.17 10.7 14.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SID-1_RNA_chan PF13965.6 CDI86647.1 - 0.15 10.4 7.8 0.15 10.4 7.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF5308 PF17233.2 CDI86647.1 - 0.17 12.1 12.4 0.19 11.9 12.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Scs3p PF10261.9 CDI86647.1 - 0.17 11.4 4.8 0.2 11.2 4.8 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM RBM39linker PF15519.6 CDI86647.1 - 0.18 12.9 13.7 0.31 12.1 13.7 1.5 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein DUF4228 PF14009.6 CDI86647.1 - 0.18 12.2 6.0 0.18 12.2 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) PAT1 PF09770.9 CDI86647.1 - 0.19 10.0 29.3 0.2 9.9 29.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CBP_BcsG PF11658.8 CDI86647.1 - 0.21 9.9 11.6 0.21 10.0 11.6 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Ctr PF04145.15 CDI86647.1 - 0.23 12.1 11.2 0.24 12.0 11.2 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Ureide_permease PF07168.11 CDI86647.1 - 0.24 10.1 5.6 0.25 10.1 5.6 1.1 1 0 0 1 1 1 0 Ureide permease DUF4746 PF15928.5 CDI86647.1 - 0.25 10.7 13.5 0.29 10.5 13.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Peptidase_S49_N PF08496.10 CDI86647.1 - 0.28 11.2 16.4 0.4 10.7 16.4 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4471 PF14740.6 CDI86647.1 - 0.28 10.3 13.6 0.34 10.1 13.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) Asparaginase_2 PF01112.18 CDI86647.1 - 0.29 10.1 9.9 0.29 10.1 9.9 1.0 1 0 0 1 1 1 0 Asparaginase Neur_chan_memb PF02932.16 CDI86647.1 - 0.3 11.1 13.8 0.32 11.0 13.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EOS1 PF12326.8 CDI86647.1 - 0.3 11.0 10.0 0.35 10.8 10.0 1.1 1 0 0 1 1 1 0 N-glycosylation protein DUF4638 PF15472.6 CDI86647.1 - 0.32 10.7 13.9 0.36 10.5 13.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Sec62 PF03839.16 CDI86647.1 - 0.32 10.5 12.0 0.36 10.3 12.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 MDM10 PF12519.8 CDI86647.1 - 0.37 9.6 13.1 0.37 9.6 13.1 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Folate_carrier PF01770.18 CDI86647.1 - 0.37 9.5 8.7 0.41 9.3 8.7 1.2 1 0 0 1 1 1 0 Reduced folate carrier DUF4446 PF14584.6 CDI86647.1 - 0.37 10.8 6.2 0.44 10.5 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) ALMT PF11744.8 CDI86647.1 - 0.45 9.3 14.1 0.47 9.2 14.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM60A PF15396.6 CDI86647.1 - 0.48 10.4 15.3 0.58 10.1 15.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A HCO3_cotransp PF00955.21 CDI86647.1 - 0.51 9.1 7.2 0.48 9.2 7.2 1.0 1 0 0 1 1 1 0 HCO3- transporter family Gti1_Pac2 PF09729.9 CDI86647.1 - 0.52 10.4 14.7 0.59 10.2 14.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Peptidase_U57 PF05582.12 CDI86647.1 - 0.54 9.5 10.9 0.56 9.4 10.9 1.1 1 0 0 1 1 1 0 YabG peptidase U57 NARP1 PF12569.8 CDI86647.1 - 0.56 9.0 16.0 0.62 8.9 16.0 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CobT PF06213.12 CDI86647.1 - 0.57 9.5 28.2 0.68 9.3 28.2 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Zip PF02535.22 CDI86647.1 - 0.61 9.2 9.0 0.61 9.2 9.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Cellulose_synt PF03552.14 CDI86647.1 - 0.71 8.3 7.4 0.75 8.2 7.4 1.0 1 0 0 1 1 1 0 Cellulose synthase R_equi_Vir PF05526.11 CDI86647.1 - 0.72 9.7 4.0 0.82 9.5 4.0 1.2 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Pannexin_like PF12534.8 CDI86647.1 - 0.76 8.8 13.5 0.74 8.8 13.5 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Baculo_PP31 PF05311.11 CDI86647.1 - 0.79 9.2 15.2 0.91 9.0 15.2 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) FYDLN_acid PF09538.10 CDI86647.1 - 0.79 10.4 10.4 0.98 10.1 10.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Peptidase_S64 PF08192.11 CDI86647.1 - 0.81 8.1 17.3 0.85 8.0 17.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 Mem_trans PF03547.18 CDI86647.1 - 0.84 8.0 5.5 0.86 7.9 5.5 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF853 PF05872.12 CDI86647.1 - 0.89 8.1 12.2 1 7.9 12.2 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF2370 PF10176.9 CDI86647.1 - 0.9 9.1 8.7 1 9.0 8.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Folliculin PF11704.8 CDI86647.1 - 0.93 9.3 15.1 1.1 9.1 15.1 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Membralin PF09746.9 CDI86647.1 - 0.93 8.5 12.9 1.1 8.3 12.9 1.1 1 0 0 1 1 1 0 Tumour-associated protein CDC45 PF02724.14 CDI86647.1 - 1 7.5 17.3 1.2 7.4 17.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Nucleoside_tran PF01733.18 CDI86647.1 - 1 8.6 5.1 1 8.7 5.1 1.1 1 0 0 1 1 1 0 Nucleoside transporter MDM31_MDM32 PF08118.11 CDI86647.1 - 1.1 7.8 12.7 1.3 7.6 12.7 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins MMR1 PF08505.10 CDI86647.1 - 1.2 9.3 21.5 1.6 9.0 21.5 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Band_3_cyto PF07565.13 CDI86647.1 - 1.3 8.7 18.5 1.5 8.6 18.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain BORG_CEP PF14957.6 CDI86647.1 - 1.3 10.2 11.8 1.5 10.0 11.8 1.1 1 0 0 1 1 1 0 Cdc42 effector DUF1980 PF09323.10 CDI86647.1 - 1.4 8.8 12.3 1.5 8.7 12.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF3276 PF11680.8 CDI86647.1 - 1.4 9.1 12.8 2.3 8.4 12.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) Pal1 PF08316.11 CDI86647.1 - 1.4 9.7 7.4 1.6 9.4 7.4 1.2 1 0 0 1 1 1 0 Pal1 cell morphology protein CTU2 PF10288.9 CDI86647.1 - 1.4 9.2 18.5 1.7 8.9 18.5 1.2 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 DUF1764 PF08576.10 CDI86647.1 - 1.4 9.8 15.7 1.9 9.4 15.7 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Otopetrin PF03189.13 CDI86647.1 - 1.4 7.6 11.7 1.5 7.5 11.7 1.1 1 0 0 1 1 1 0 Otopetrin Spc7_N PF15402.6 CDI86647.1 - 1.4 7.0 20.7 1.7 6.8 20.7 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF4770 PF15994.5 CDI86647.1 - 1.5 9.1 20.1 2 8.6 20.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) PepSY_TM PF03929.16 CDI86647.1 - 1.5 8.4 10.2 1.7 8.3 10.2 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Sugar_tr PF00083.24 CDI86647.1 - 1.5 7.6 3.2 1.5 7.6 3.2 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter YABBY PF04690.13 CDI86647.1 - 1.7 9.2 15.1 2 9.0 15.1 1.1 1 0 0 1 1 1 0 YABBY protein PRC2_HTH_1 PF18118.1 CDI86647.1 - 2 9.2 13.2 2.6 8.9 13.2 1.2 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Hid1 PF12722.7 CDI86647.1 - 2.2 6.3 17.1 2.4 6.2 17.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein IPK PF03770.16 CDI86647.1 - 2.2 8.1 13.6 60 3.4 13.6 2.0 1 1 0 1 1 1 0 Inositol polyphosphate kinase PTPRCAP PF15713.5 CDI86647.1 - 2.3 8.5 19.8 2.7 8.3 19.8 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Lin-8 PF03353.15 CDI86647.1 - 2.4 7.6 24.7 2.8 7.4 24.7 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Endonuc_Holl PF10107.9 CDI86647.1 - 2.8 7.8 14.6 3.4 7.5 14.6 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase DUF2126 PF09899.9 CDI86647.1 - 2.9 5.9 14.0 3.1 5.8 14.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) UPF0560 PF10577.9 CDI86647.1 - 2.9 6.3 28.6 3.1 6.2 28.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DDRGK PF09756.9 CDI86647.1 - 3.1 7.4 28.6 3.8 7.1 28.6 1.1 1 0 0 1 1 1 0 DDRGK domain MAJIN PF15077.6 CDI86647.1 - 3.3 7.5 12.7 3.5 7.3 12.7 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein SART-1 PF03343.13 CDI86647.1 - 3.5 6.0 23.0 4.1 5.8 23.0 1.0 1 0 0 1 1 1 0 SART-1 family DUF1800 PF08811.11 CDI86647.1 - 3.6 6.5 19.7 4.2 6.3 19.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) Spore_coat_CotO PF14153.6 CDI86647.1 - 3.7 7.4 27.4 4.4 7.2 27.4 1.1 1 0 0 1 1 1 0 Spore coat protein CotO O-antigen_lig PF13425.6 CDI86647.1 - 3.7 6.2 7.8 3.9 6.2 7.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Peptidase_S15 PF02129.18 CDI86647.1 - 3.9 7.0 13.9 4.2 6.9 13.9 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Gastrin PF00918.17 CDI86647.1 - 4.3 8.3 15.6 5.1 8.1 15.6 1.1 1 0 0 1 1 1 0 Gastrin/cholecystokinin family PEHE PF15275.6 CDI86647.1 - 4.4 8.0 20.2 5.9 7.5 20.2 1.2 1 0 0 1 1 1 0 PEHE domain ABC2_membrane_2 PF12679.7 CDI86647.1 - 4.4 6.5 6.9 4.8 6.4 6.9 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Conotoxin PF02950.17 CDI86647.1 - 4.5 8.4 18.2 11 7.1 7.3 2.1 1 1 1 2 2 2 0 Conotoxin Kei1 PF08552.11 CDI86647.1 - 4.6 7.1 13.2 5.6 6.8 13.2 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DcuA_DcuB PF03605.14 CDI86647.1 - 4.9 6.0 4.7 5.6 5.7 4.7 1.3 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter GREB1 PF15782.5 CDI86647.1 - 5.2 4.1 20.1 5.8 3.9 20.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ndc1_Nup PF09531.10 CDI86647.1 - 5.4 5.6 15.6 6 5.4 15.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AIF_C PF14721.6 CDI86647.1 - 6.1 7.2 16.5 8.4 6.8 16.5 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Paramyxo_ncap PF00973.19 CDI86647.1 - 6.7 5.5 13.5 7.2 5.4 13.5 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF3405 PF11885.8 CDI86647.1 - 7 5.1 18.8 7.7 5.0 18.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) Thg1C PF14413.6 CDI86648.1 - 0.0076 16.4 2.4 0.0084 16.3 2.4 1.1 1 0 0 1 1 1 1 Thg1 C terminal domain Suf PF05843.14 CDI86648.1 - 0.01 15.9 9.5 0.01 15.9 9.5 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Nup188_C PF18378.1 CDI86648.1 - 0.018 13.9 1.5 0.019 13.8 1.5 1.0 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain Pex14_N PF04695.13 CDI86648.1 - 0.033 14.9 8.6 0.034 14.8 8.6 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2722 PF10846.8 CDI86648.1 - 0.04 12.9 20.7 0.045 12.7 20.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI86648.1 - 0.045 13.4 24.1 0.048 13.3 24.1 1.1 1 0 0 1 1 1 0 Spt20 family Nucleos_tra2_C PF07662.13 CDI86648.1 - 0.1 12.4 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 Na+ dependent nucleoside transporter C-terminus DUF2877 PF11392.8 CDI86648.1 - 0.13 13.0 1.6 0.15 12.8 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2877) EIIBC-GUT_N PF03612.14 CDI86648.1 - 0.15 11.8 2.2 0.15 11.8 2.2 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TFIIA PF03153.13 CDI86648.1 - 0.17 11.8 20.1 0.17 11.9 20.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 CDI86648.1 - 0.25 10.4 10.2 0.26 10.3 10.2 1.0 1 0 0 1 1 1 0 Drosophila roughex protein DUF3464 PF11947.8 CDI86648.1 - 0.29 10.9 4.0 0.33 10.7 4.0 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Med15 PF09606.10 CDI86648.1 - 0.29 9.8 20.7 0.29 9.8 20.7 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4834 PF16118.5 CDI86648.1 - 0.43 11.6 7.6 0.51 11.3 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TERB2 PF15101.6 CDI86648.1 - 0.49 10.4 8.2 0.47 10.5 8.2 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF775 PF05603.12 CDI86648.1 - 0.54 9.8 8.0 0.59 9.6 8.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Presenilin PF01080.17 CDI86648.1 - 0.72 8.6 4.8 0.77 8.5 4.8 1.0 1 0 0 1 1 1 0 Presenilin PepSY_TM PF03929.16 CDI86648.1 - 0.75 9.4 2.3 0.76 9.4 2.3 1.1 1 0 0 1 1 1 0 PepSY-associated TM region MscS_TM PF12794.7 CDI86648.1 - 1.2 7.9 4.0 1.2 7.9 4.0 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF4199 PF13858.6 CDI86648.1 - 2.9 8.3 4.6 3.2 8.1 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF4175 PF13779.6 CDI86648.1 - 3.2 5.5 18.9 3.2 5.5 18.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TMEM51 PF15345.6 CDI86648.1 - 3.4 7.4 10.0 4.1 7.2 10.0 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 UPF0560 PF10577.9 CDI86648.1 - 4.2 5.8 11.9 4.2 5.8 11.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DivIC PF04977.15 CDI86648.1 - 5.5 6.8 15.9 7.2 6.5 15.9 1.2 1 0 0 1 1 1 0 Septum formation initiator DUF5349 PF17298.2 CDI86648.1 - 9.2 5.9 13.6 9.8 5.8 13.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5349) AMP-binding PF00501.28 CDI86649.1 - 0.42 9.1 9.6 0.45 9.0 9.6 1.0 1 0 0 1 1 1 0 AMP-binding enzyme PPP4R2 PF09184.11 CDI86649.1 - 2.1 7.9 24.3 2.4 7.7 24.3 1.1 1 0 0 1 1 1 0 PPP4R2 LRR19-TM PF15176.6 CDI86650.1 - 0.00077 19.4 0.0 0.001 19.1 0.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain PrpF PF04303.13 CDI86650.1 - 0.13 11.1 1.9 0.16 10.9 1.9 1.1 1 0 0 1 1 1 0 PrpF protein DUF3138 PF11336.8 CDI86650.1 - 0.21 10.2 9.4 0.23 10.1 9.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) OmpH PF03938.14 CDI86650.1 - 0.29 11.5 17.7 0.36 11.2 17.7 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Med3 PF11593.8 CDI86650.1 - 0.29 10.3 22.9 0.32 10.1 22.9 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal CAML PF14963.6 CDI86650.1 - 0.42 10.7 2.1 0.48 10.5 2.1 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand DUF2232 PF09991.9 CDI86650.1 - 0.51 9.5 4.2 0.62 9.2 4.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) EIF4E-T PF10477.9 CDI86650.1 - 0.94 8.2 9.6 0.86 8.4 9.6 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E R_equi_Vir PF05526.11 CDI86650.1 - 1.1 9.2 6.5 1.3 8.8 6.5 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein RskA PF10099.9 CDI86650.1 - 1.7 8.9 24.5 5.2 7.3 24.5 1.7 1 1 0 1 1 1 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI86650.1 - 3.5 7.5 26.8 3.6 7.5 26.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4179 PF13786.6 CDI86650.1 - 7.4 7.1 9.3 21 5.6 9.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) WW PF00397.26 CDI86651.1 - 2.3e-16 59.5 9.5 9.9e-10 38.3 2.3 2.7 2 0 0 2 2 2 2 WW domain FF PF01846.19 CDI86651.1 - 6.2e-11 42.3 0.0 6.2e-11 42.3 0.0 3.4 3 0 0 3 3 3 1 FF domain TetR_C_7 PF14246.6 CDI86651.1 - 0.032 14.2 0.4 3.1 7.9 0.0 2.4 2 0 0 2 2 2 0 AefR-like transcriptional repressor, C-terminal domain IMUP PF15761.5 CDI86651.1 - 0.14 12.8 21.6 0.45 11.2 21.6 1.8 1 0 0 1 1 1 0 Immortalisation up-regulated protein PPP4R2 PF09184.11 CDI86651.1 - 0.92 9.0 24.4 2.3 7.7 24.4 1.7 1 0 0 1 1 1 0 PPP4R2 Coilin_N PF15862.5 CDI86653.1 - 0.01 15.7 1.0 0.01 15.7 1.0 6.2 5 1 0 5 5 5 0 Coilin N-terminus BT1 PF03092.16 CDI86653.1 - 2.8 6.1 6.9 0.66 8.1 3.0 1.9 2 0 0 2 2 2 0 BT1 family Zip PF02535.22 CDI86655.1 - 3.6e-06 26.4 9.7 4.1e-06 26.2 9.7 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter O-antigen_lig PF13425.6 CDI86655.1 - 0.0066 15.3 0.0 0.0089 14.9 0.0 1.3 1 0 0 1 1 1 1 O-antigen ligase like membrane protein RR_TM4-6 PF06459.12 CDI86655.1 - 0.012 15.5 17.6 0.012 15.4 17.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CD20 PF04103.15 CDI86655.1 - 0.015 15.4 2.1 0.015 15.4 2.1 2.4 1 1 1 2 2 2 0 CD20-like family PPP4R2 PF09184.11 CDI86655.1 - 0.021 14.4 6.7 0.022 14.4 6.7 1.2 1 0 0 1 1 1 0 PPP4R2 DUF2339 PF10101.9 CDI86655.1 - 0.028 13.0 23.2 0.03 12.9 23.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) SID-1_RNA_chan PF13965.6 CDI86655.1 - 0.03 12.7 6.3 0.038 12.4 6.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Myc_N PF01056.18 CDI86655.1 - 0.05 13.5 17.4 0.072 13.0 17.4 1.3 1 0 0 1 1 1 0 Myc amino-terminal region SLC12 PF03522.15 CDI86655.1 - 0.14 11.1 18.5 0.18 10.8 18.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Raftlin PF15250.6 CDI86655.1 - 0.15 10.8 13.7 0.15 10.8 13.7 1.2 1 0 0 1 1 1 0 Raftlin eIF-3_zeta PF05091.12 CDI86655.1 - 0.18 10.8 18.2 0.24 10.3 18.2 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SAPS PF04499.15 CDI86655.1 - 0.21 10.4 12.6 0.21 10.3 12.6 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF726 PF05277.12 CDI86655.1 - 0.27 10.1 8.6 0.37 9.7 8.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF726) GAGA_bind PF06217.12 CDI86655.1 - 0.28 11.4 16.8 0.32 11.2 16.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family FAM91_C PF14648.6 CDI86655.1 - 0.48 9.2 9.0 0.51 9.1 9.0 1.3 1 0 0 1 1 1 0 FAM91 C-terminus SPX PF03105.19 CDI86655.1 - 0.52 10.2 15.7 0.68 9.8 15.7 1.1 1 0 0 1 1 1 0 SPX domain TraX PF05857.11 CDI86655.1 - 0.64 10.0 5.6 0.82 9.7 5.6 1.2 1 0 0 1 1 1 0 TraX protein V_ATPase_I PF01496.19 CDI86655.1 - 0.83 7.5 19.7 1.2 7.0 19.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MAJIN PF15077.6 CDI86655.1 - 0.93 9.2 13.6 1.4 8.7 13.6 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein TFIIA PF03153.13 CDI86655.1 - 1.1 9.2 59.2 1.4 8.8 59.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDK5_activator PF03261.15 CDI86655.1 - 1.3 8.5 14.4 1.3 8.4 14.4 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Macoilin PF09726.9 CDI86655.1 - 1.6 7.2 21.4 1.9 6.9 21.4 1.2 1 0 0 1 1 1 0 Macoilin family FAM60A PF15396.6 CDI86655.1 - 1.7 8.6 17.9 2.6 8.0 17.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A HCO3_cotransp PF00955.21 CDI86655.1 - 1.8 7.3 8.0 2.3 7.0 8.0 1.3 1 0 0 1 1 1 0 HCO3- transporter family Nha1_C PF08619.10 CDI86655.1 - 2.9 7.0 23.8 4.2 6.5 23.8 1.2 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus NPR3 PF03666.13 CDI86655.1 - 6 5.5 21.9 9.4 4.9 21.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Trp_oprn_chp PF09534.10 CDI86655.1 - 8.3 6.2 44.6 1.3e+02 2.2 44.5 2.4 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF966 PF06136.13 CDI86655.1 - 9.3 5.8 17.9 13 5.4 17.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF3446 PF11928.8 CDI86656.1 - 1.2e-05 25.6 29.4 0.0017 18.6 9.5 2.5 2 0 0 2 2 2 2 Early growth response N-terminal domain NAM-associated PF14303.6 CDI86656.1 - 0.00088 20.0 1.1 0.00088 20.0 1.1 2.1 2 0 0 2 2 2 1 No apical meristem-associated C-terminal domain Secretin_N_2 PF07655.13 CDI86656.1 - 0.0018 18.8 23.3 0.14 12.7 3.4 2.3 2 0 0 2 2 2 2 Secretin N-terminal domain POX PF07526.11 CDI86656.1 - 0.0039 17.8 3.7 0.087 13.4 1.5 2.2 2 0 0 2 2 2 1 Associated with HOX SPX PF03105.19 CDI86656.1 - 0.079 12.9 8.8 0.11 12.4 8.8 1.2 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI86656.1 - 0.13 11.1 12.4 0.19 10.6 12.4 1.3 1 1 0 1 1 1 0 Golgi-body localisation protein domain SR-25 PF10500.9 CDI86656.1 - 0.23 11.0 38.7 0.63 9.6 14.5 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Dus PF01207.17 CDI86656.1 - 0.25 10.4 0.0 0.84 8.7 0.0 1.7 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) CCDC24 PF15669.5 CDI86656.1 - 0.33 10.8 11.6 0.34 10.8 2.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family DUF1645 PF07816.11 CDI86656.1 - 1.3 9.6 19.7 1.7 9.2 6.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) Lin-8 PF03353.15 CDI86656.1 - 2.2 7.7 6.7 4 6.9 1.0 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist GEMIN8 PF15348.6 CDI86656.1 - 2.3 8.5 8.1 0.88 9.8 3.1 2.0 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 CDK2AP PF09806.9 CDI86656.1 - 4.5 7.3 12.5 8.7 6.3 0.5 2.1 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein TraG-D_C PF12696.7 CDI86656.1 - 5.7 6.9 11.3 5.7 6.9 2.7 2.3 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG SelP_N PF04592.14 CDI86657.1 - 4.2 6.7 25.8 4.5 6.6 25.8 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region HapK PF11639.8 CDI86658.1 - 0.031 14.8 0.0 0.071 13.6 0.0 1.5 1 0 0 1 1 1 0 REDY-like protein HapK ANAPC3 PF12895.7 CDI86659.1 - 0.0038 17.4 0.1 0.0058 16.8 0.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 CDI86659.1 - 0.0081 16.9 0.3 0.019 15.7 0.3 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDI86659.1 - 0.1 12.8 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat PPR_1 PF12854.7 CDI86659.1 - 0.18 11.5 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 PPR repeat DUF4597 PF15366.6 CDI86660.1 - 0.014 15.1 2.9 0.041 13.6 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4597) SUIM_assoc PF16619.5 CDI86663.1 - 0.032 14.3 7.6 0.032 14.3 7.6 2.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI86663.1 - 0.055 13.5 29.1 0.065 13.2 29.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit VIT1 PF01988.19 CDI86664.1 - 0.013 15.3 6.8 0.019 14.8 6.8 1.2 1 0 0 1 1 1 0 VIT family Zip PF02535.22 CDI86664.1 - 0.02 14.1 2.7 0.023 13.9 2.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 CDI86664.1 - 0.029 13.1 17.2 0.03 13.1 17.2 1.1 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 CDI86664.1 - 0.04 12.2 28.8 0.043 12.1 28.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 UPF0014 PF03649.13 CDI86664.1 - 0.045 13.1 1.4 0.05 13.0 0.2 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0014) CCSAP PF15748.5 CDI86664.1 - 0.049 13.8 16.8 0.056 13.6 16.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 CDI86664.1 - 0.053 12.5 15.4 0.058 12.4 15.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CDK5_activator PF03261.15 CDI86664.1 - 0.077 12.5 12.8 0.087 12.4 12.8 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein MRP-S31 PF15433.6 CDI86664.1 - 0.15 11.7 17.8 0.18 11.4 17.8 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Lin-8 PF03353.15 CDI86664.1 - 0.16 11.5 20.5 0.19 11.3 20.5 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Smg8_Smg9 PF10220.9 CDI86664.1 - 0.18 10.1 14.9 0.2 9.9 14.9 1.0 1 0 0 1 1 1 0 Smg8_Smg9 SID-1_RNA_chan PF13965.6 CDI86664.1 - 0.18 10.2 4.9 0.22 9.9 4.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Trp_oprn_chp PF09534.10 CDI86664.1 - 0.2 11.4 8.6 17 5.2 8.6 2.2 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) eIF-3_zeta PF05091.12 CDI86664.1 - 0.23 10.4 17.3 0.32 9.9 17.3 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) V_ATPase_I PF01496.19 CDI86664.1 - 0.23 9.3 13.9 0.25 9.2 13.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 CDI86664.1 - 0.29 9.4 15.6 0.34 9.2 15.6 1.0 1 0 0 1 1 1 0 CDC45-like protein ALMT PF11744.8 CDI86664.1 - 0.31 9.8 10.7 0.35 9.6 10.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PTPRCAP PF15713.5 CDI86664.1 - 0.32 11.3 19.4 0.45 10.8 19.4 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Membralin PF09746.9 CDI86664.1 - 0.53 9.3 8.3 0.54 9.2 8.3 1.1 1 0 0 1 1 1 0 Tumour-associated protein FAM60A PF15396.6 CDI86664.1 - 0.55 10.2 12.8 0.75 9.8 12.8 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Hydin_ADK PF17213.3 CDI86664.1 - 0.56 10.5 15.8 0.74 10.1 15.8 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain CLN3 PF02487.17 CDI86664.1 - 0.58 9.1 9.0 0.71 8.9 9.0 1.3 1 0 0 1 1 1 0 CLN3 protein DUF4045 PF13254.6 CDI86664.1 - 0.78 9.3 15.7 0.83 9.2 15.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PA26 PF04636.13 CDI86664.1 - 0.96 8.3 12.3 1 8.2 12.3 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) O-antigen_lig PF13425.6 CDI86664.1 - 1 8.1 6.5 1.2 7.8 6.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF3292 PF11696.8 CDI86664.1 - 1.1 7.6 11.9 1.4 7.2 11.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Gti1_Pac2 PF09729.9 CDI86664.1 - 1.1 9.3 12.3 1.6 8.8 12.3 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family GREB1 PF15782.5 CDI86664.1 - 1.3 6.1 17.3 1.4 5.9 17.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ribosomal_60s PF00428.19 CDI86664.1 - 1.3 9.6 7.8 4.8 7.8 0.8 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF2151 PF10221.9 CDI86664.1 - 1.4 7.4 11.5 1.6 7.2 11.5 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator RskA PF10099.9 CDI86664.1 - 1.7 8.9 31.0 3.6e+03 -1.9 31.5 2.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA TCP PF03634.13 CDI86664.1 - 1.7 9.2 20.0 2.3 8.8 20.0 1.2 1 0 0 1 1 1 0 TCP family transcription factor Senescence_reg PF04520.13 CDI86664.1 - 2.5 8.9 15.1 3.2 8.6 15.1 1.2 1 0 0 1 1 1 0 Senescence regulator Exonuc_VII_L PF02601.15 CDI86664.1 - 2.8 7.4 20.3 3.2 7.3 20.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit NEMP PF10225.9 CDI86664.1 - 2.9 7.5 13.2 22 4.6 13.2 1.9 1 1 0 1 1 1 0 NEMP family HemX PF04375.14 CDI86664.1 - 2.9 7.1 38.4 3.5 6.8 38.4 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase RR_TM4-6 PF06459.12 CDI86664.1 - 3.2 7.5 18.4 3.9 7.2 18.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4746 PF15928.5 CDI86664.1 - 3.5 7.0 13.4 4.4 6.6 13.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Neur_chan_memb PF02932.16 CDI86664.1 - 3.6 7.6 15.5 4.5 7.2 15.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MMR1 PF08505.10 CDI86664.1 - 3.6 7.8 22.8 4.7 7.4 22.8 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Serinc PF03348.15 CDI86664.1 - 3.9 6.3 8.2 6.7 5.5 8.2 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) DDRGK PF09756.9 CDI86664.1 - 4.3 6.9 27.7 6.1 6.4 27.7 1.2 1 0 0 1 1 1 0 DDRGK domain MRP-S26 PF14943.6 CDI86664.1 - 4.7 7.1 21.6 6.8 6.6 21.6 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 MDM10 PF12519.8 CDI86664.1 - 5.5 5.8 15.1 6.7 5.5 15.1 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Ndc1_Nup PF09531.10 CDI86664.1 - 6 5.4 15.6 6.7 5.3 15.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Peptidase_S64 PF08192.11 CDI86664.1 - 7.3 5.0 16.1 8.8 4.7 16.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 SR-25 PF10500.9 CDI86666.1 - 0.0054 16.4 21.2 0.0067 16.1 21.2 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein MID_MedPIWI PF18296.1 CDI86666.1 - 0.1 12.4 22.2 0.13 12.0 22.2 1.1 1 0 0 1 1 1 0 MID domain of medPIWI DUF5349 PF17298.2 CDI86666.1 - 0.13 12.0 27.6 0.15 11.8 27.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5349) Nop53 PF07767.11 CDI86666.1 - 0.15 11.5 24.2 0.18 11.2 24.2 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Menin PF05053.13 CDI86666.1 - 0.21 9.9 22.2 0.28 9.5 22.2 1.2 1 0 0 1 1 1 0 Menin ASD2 PF08687.11 CDI86666.1 - 0.3 10.6 20.8 0.34 10.4 20.8 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 PA26 PF04636.13 CDI86666.1 - 0.34 9.8 16.2 0.38 9.6 16.2 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) YL1 PF05764.13 CDI86666.1 - 0.44 10.6 25.7 0.55 10.3 25.7 1.0 1 0 0 1 1 1 0 YL1 nuclear protein Zip PF02535.22 CDI86666.1 - 0.45 9.7 12.6 0.5 9.5 12.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CCDC106 PF15794.5 CDI86666.1 - 0.54 9.9 22.0 0.63 9.7 22.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Dicty_REP PF05086.12 CDI86666.1 - 0.71 7.8 22.9 0.79 7.6 22.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Suf PF05843.14 CDI86666.1 - 0.88 9.5 27.6 1.2 9.0 27.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SID-1_RNA_chan PF13965.6 CDI86666.1 - 1.2 7.4 9.5 1.6 7.1 9.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 FAM60A PF15396.6 CDI86666.1 - 1.4 8.9 18.2 1.8 8.5 18.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF4050 PF13259.6 CDI86666.1 - 1.4 9.2 19.5 1.9 8.8 19.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) DUF913 PF06025.12 CDI86666.1 - 1.6 7.6 14.0 2.3 7.1 14.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Striatin PF08232.12 CDI86666.1 - 1.7 9.2 22.7 2.3 8.8 22.7 1.2 1 0 0 1 1 1 0 Striatin family DUF3824 PF12868.7 CDI86666.1 - 1.8 9.3 21.9 0.22 12.2 8.4 2.0 1 1 1 2 2 2 0 Domain of unknwon function (DUF3824) TFIIA PF03153.13 CDI86666.1 - 2 8.3 43.7 2.5 8.0 43.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 CDI86666.1 - 2.2 8.0 21.3 2.5 7.9 21.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SMYLE_N PF18615.1 CDI86666.1 - 2.5 7.6 20.0 2.9 7.3 20.0 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain CDC45 PF02724.14 CDI86666.1 - 2.7 6.2 22.0 3.2 5.9 22.0 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF572 PF04502.13 CDI86666.1 - 3.1 7.3 22.4 3.7 7.1 22.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) IMUP PF15761.5 CDI86666.1 - 3.2 8.5 20.1 4.4 8.0 18.2 1.7 1 1 1 2 2 2 0 Immortalisation up-regulated protein DUF2126 PF09899.9 CDI86666.1 - 3.6 5.6 11.4 3.7 5.5 11.4 1.3 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) SLC12 PF03522.15 CDI86666.1 - 4.1 6.3 23.3 4.6 6.1 23.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 LAP1C PF05609.12 CDI86666.1 - 4.5 6.3 25.5 4.8 6.1 25.5 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Hydin_ADK PF17213.3 CDI86666.1 - 4.5 7.5 26.2 5.4 7.3 26.2 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain XAP5 PF04921.14 CDI86666.1 - 4.7 7.0 17.7 5.5 6.8 17.7 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator Presenilin PF01080.17 CDI86666.1 - 5.6 5.6 31.9 6.6 5.4 31.9 1.0 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 CDI86666.1 - 5.6 5.0 26.0 6.4 4.8 26.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DAG_kinase_N PF14513.6 CDI86666.1 - 6 7.0 19.8 8.1 6.6 19.8 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus HemX PF04375.14 CDI86666.1 - 6.1 6.0 32.3 9.8 5.4 32.3 1.3 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Neur_chan_memb PF02932.16 CDI86666.1 - 7 6.6 16.4 8.4 6.4 16.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MMR1 PF08505.10 CDI86666.1 - 7.1 6.8 29.8 8.7 6.5 29.8 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein NPR3 PF03666.13 CDI86666.1 - 8.2 5.1 25.3 9.4 4.9 25.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 HCO3_cotransp PF00955.21 CDI86666.1 - 8.2 5.1 10.3 8.8 5.0 10.3 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF5427 PF10310.9 CDI86666.1 - 8.4 5.2 26.8 10 4.9 26.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) AUX_IAA PF02309.16 CDI86666.1 - 9.8 5.9 17.6 11 5.8 17.6 1.1 1 0 0 1 1 1 0 AUX/IAA family DUF2754 PF10953.8 CDI86667.1 - 0.051 13.8 0.2 0.051 13.8 0.2 1.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2754) Peptidase_M20 PF01546.28 CDI86668.1 - 4.1e-30 105.0 0.3 7.7e-30 104.1 0.3 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CDI86668.1 - 1.9e-10 40.6 0.0 5.2e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain DUF5345 PF17280.2 CDI86668.1 - 0.96 9.5 3.4 2.4 8.2 3.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Ribosomal_L16 PF00252.18 CDI86670.1 - 1.5e-36 125.3 0.1 1.1e-34 119.2 0.1 2.1 1 1 0 1 1 1 1 Ribosomal protein L16p/L10e BCAS2 PF05700.11 CDI86671.1 - 2.4e-45 154.7 4.6 3.2e-45 154.4 4.6 1.2 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) TMF_TATA_bd PF12325.8 CDI86671.1 - 2.4 8.4 9.0 0.085 13.1 3.0 1.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF3494 PF11999.8 CDI86672.1 - 4.7 6.8 11.9 0.081 12.6 3.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3494) PIG-L PF02585.17 CDI86673.1 - 2.2e-18 67.2 0.0 6.7e-18 65.6 0.0 1.9 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DUF4746 PF15928.5 CDI86673.1 - 0.56 9.6 10.7 3.1 7.1 3.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) TRAP_alpha PF03896.16 CDI86673.1 - 0.59 9.3 5.4 4 6.6 1.3 2.6 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit SpoIIP PF07454.11 CDI86673.1 - 0.83 9.1 7.8 6.6 6.1 1.0 2.5 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 CDI86673.1 - 1 9.1 6.5 9.4 5.9 1.2 2.6 3 0 0 3 3 3 0 Connexin Secretin_N_2 PF07655.13 CDI86673.1 - 1.6 9.3 23.0 4.4 7.9 7.7 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain HAUS6_N PF14661.6 CDI86673.1 - 2.2 7.8 13.8 0.16 11.6 3.7 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Presenilin PF01080.17 CDI86673.1 - 4 6.1 19.4 0.69 8.6 7.7 3.0 2 1 1 3 3 3 0 Presenilin Plasmodium_Vir PF05795.11 CDI86673.1 - 4.4 6.6 11.8 0.29 10.5 2.6 2.7 3 0 0 3 3 3 0 Plasmodium vivax Vir protein Sec62 PF03839.16 CDI86673.1 - 4.8 6.6 7.2 3.7 7.0 1.7 2.3 2 0 0 2 2 2 0 Translocation protein Sec62 Peptidase_S49_N PF08496.10 CDI86673.1 - 8.8 6.4 10.0 7.9 6.5 2.0 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal CS PF04969.16 CDI86674.1 - 2.2e-06 28.6 0.0 8.9e-06 26.6 0.0 2.0 1 1 0 1 1 1 1 CS domain SR-25 PF10500.9 CDI86674.1 - 0.017 14.7 14.4 0.017 14.7 14.4 3.5 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein CDC37_N PF03234.14 CDI86674.1 - 0.042 14.8 0.7 0.042 14.8 0.7 4.3 4 1 0 4 4 4 0 Cdc37 N terminal kinase binding Folliculin PF11704.8 CDI86674.1 - 0.29 11.0 6.2 0.28 11.0 0.2 2.6 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Secretin_N_2 PF07655.13 CDI86674.1 - 0.84 10.2 24.1 0.4 11.2 6.7 3.3 3 0 0 3 3 3 0 Secretin N-terminal domain COX2 PF00116.20 CDI86675.1 - 2.2e-43 147.0 0.0 3e-43 146.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain RskA PF10099.9 CDI86676.1 - 0.0059 16.9 8.6 0.0059 16.9 8.6 5.1 1 1 1 3 3 3 1 Anti-sigma-K factor rskA RskA PF10099.9 CDI86677.1 - 3.2e-07 30.8 15.1 3.2e-07 30.8 15.1 3.9 1 1 3 4 4 2 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI86677.1 - 0.016 14.8 30.8 0.016 14.8 30.8 3.1 2 1 1 3 3 2 0 Spt20 family TFB6 PF17110.5 CDI86677.1 - 0.18 11.6 0.1 0.18 11.6 0.1 3.0 2 1 0 2 2 1 0 Subunit 11 of the general transcription factor TFIIH Utp14 PF04615.13 CDI86677.1 - 0.46 9.0 28.7 0.75 8.3 28.7 1.3 1 0 0 1 1 1 0 Utp14 protein MGC-24 PF05283.11 CDI86677.1 - 0.53 10.7 20.3 1.3 9.5 1.2 2.3 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Tic110 PF16940.5 CDI86677.1 - 1 7.8 26.6 0.059 11.8 1.1 2.2 2 0 0 2 2 2 0 Chloroplast envelope transporter Draxin PF15550.6 CDI86677.1 - 1.2 8.9 22.9 2.5 7.9 3.1 2.3 2 0 0 2 2 2 0 Draxin GAGA_bind PF06217.12 CDI86677.1 - 3.4 7.9 32.0 1.4 9.1 18.0 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family DUF4834 PF16118.5 CDI86677.1 - 6.2 7.8 43.9 2.3 9.3 12.6 3.3 2 1 0 2 2 1 0 Domain of unknown function (DUF4834) PA26 PF04636.13 CDI86677.1 - 7.5 5.4 27.7 4.9 6.0 7.0 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) SID-1_RNA_chan PF13965.6 CDI86677.1 - 7.6 4.8 16.9 1 7.7 4.1 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Suf PF05843.14 CDI86677.1 - 8.9 6.2 42.5 0.64 10.0 13.4 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF2722 PF10846.8 CDI86678.1 - 0.00017 20.7 8.0 0.00017 20.7 8.0 3.4 2 1 0 2 2 1 1 Protein of unknown function (DUF2722) DUF4834 PF16118.5 CDI86678.1 - 0.00087 20.2 25.3 0.092 13.7 13.1 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) Activator_LAG-3 PF11498.8 CDI86678.1 - 0.00088 18.4 65.1 0.0015 17.6 14.3 2.5 2 0 0 2 2 2 2 Transcriptional activator LAG-3 FAM176 PF14851.6 CDI86678.1 - 0.015 15.0 8.0 0.015 15.0 8.0 2.3 2 0 0 2 2 2 0 FAM176 family CNDH2_C PF16858.5 CDI86678.1 - 0.017 15.0 22.7 0.051 13.4 12.1 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SID-1_RNA_chan PF13965.6 CDI86678.1 - 0.06 11.8 9.1 0.059 11.8 4.2 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 EOS1 PF12326.8 CDI86678.1 - 0.075 13.0 6.4 0.5 10.3 1.7 2.3 2 0 0 2 2 2 0 N-glycosylation protein FAM91_C PF14648.6 CDI86678.1 - 0.099 11.5 9.8 1.2 7.9 4.6 2.1 2 0 0 2 2 2 0 FAM91 C-terminus FAM60A PF15396.6 CDI86678.1 - 0.12 12.3 13.7 0.36 10.8 5.8 2.3 2 0 0 2 2 2 0 Protein Family FAM60A Connexin PF00029.19 CDI86678.1 - 0.14 11.9 17.3 0.14 11.9 8.5 2.1 2 0 0 2 2 2 0 Connexin DUF2828 PF11443.8 CDI86678.1 - 0.16 10.1 20.3 0.015 13.4 8.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) eIF-3_zeta PF05091.12 CDI86678.1 - 0.16 10.9 29.9 0.84 8.5 17.4 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TRAP_alpha PF03896.16 CDI86678.1 - 0.17 11.1 15.8 0.13 11.4 6.3 2.4 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Peptidase_S49_N PF08496.10 CDI86678.1 - 0.18 11.9 17.3 1 9.4 9.5 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal FAM76 PF16046.5 CDI86678.1 - 0.19 11.1 21.3 0.22 10.8 9.6 2.1 2 0 0 2 2 2 0 FAM76 protein SOBP PF15279.6 CDI86678.1 - 0.21 12.2 24.9 1 9.9 6.6 2.3 2 0 0 2 2 2 0 Sine oculis-binding protein SpoIIP PF07454.11 CDI86678.1 - 0.28 10.6 28.8 0.44 10.0 15.5 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) CSG2 PF16965.5 CDI86678.1 - 0.34 9.8 13.4 0.075 12.0 6.1 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator Folate_carrier PF01770.18 CDI86678.1 - 0.41 9.3 13.4 0.22 10.2 4.4 2.3 2 0 0 2 2 2 0 Reduced folate carrier U1snRNP70_N PF12220.8 CDI86678.1 - 0.44 11.2 18.3 1.9 9.2 9.0 2.6 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal MecA PF05389.12 CDI86678.1 - 0.52 9.9 17.8 0.75 9.4 7.8 2.4 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) Dpy19 PF10034.9 CDI86678.1 - 0.58 8.3 10.7 0.14 10.3 4.7 2.0 2 0 0 2 2 2 0 Q-cell neuroblast polarisation DUF4770 PF15994.5 CDI86678.1 - 0.68 10.1 27.9 0.12 12.6 2.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) DUF3402 PF11882.8 CDI86678.1 - 0.72 8.9 26.2 0.046 12.8 11.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3402) DUF4471 PF14740.6 CDI86678.1 - 0.72 9.0 16.6 0.88 8.7 8.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) SLC12 PF03522.15 CDI86678.1 - 0.73 8.8 24.4 0.36 9.8 11.4 2.1 2 0 0 2 2 2 0 Solute carrier family 12 PPP4R2 PF09184.11 CDI86678.1 - 0.94 9.0 13.3 0.59 9.7 5.5 2.1 2 0 0 2 2 2 0 PPP4R2 CLN3 PF02487.17 CDI86678.1 - 1 8.3 21.6 0.067 12.2 8.4 2.2 2 0 0 2 2 2 0 CLN3 protein EIF4E-T PF10477.9 CDI86678.1 - 1.1 8.0 31.3 0.24 10.2 5.4 2.1 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Pinin_SDK_memA PF04696.13 CDI86678.1 - 1.2 9.2 44.1 1.6 8.8 8.4 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region DUF2464 PF10240.9 CDI86678.1 - 1.3 8.6 12.9 0.41 10.2 3.3 2.3 2 0 0 2 2 2 0 Multivesicular body subunit 12 DUF1980 PF09323.10 CDI86678.1 - 1.3 8.9 18.9 1.8 8.4 8.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) CDK5_activator PF03261.15 CDI86678.1 - 1.7 8.1 14.3 1.2 8.6 6.7 2.1 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein Afi1 PF07792.12 CDI86678.1 - 2 8.9 24.2 1.7 9.1 13.4 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking ESM4 PF15952.5 CDI86678.1 - 2.1 8.7 34.0 1.8 9.0 19.6 2.2 2 0 0 2 2 2 0 Enhancer of split M4 family Band_3_cyto PF07565.13 CDI86678.1 - 2.4 7.9 23.2 3 7.6 11.2 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain V_ATPase_I PF01496.19 CDI86678.1 - 2.5 5.9 27.8 0.16 9.9 14.5 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family PIP5K PF01504.18 CDI86678.1 - 3.4 6.8 21.3 4.4 6.4 0.7 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase OATP PF03137.20 CDI86678.1 - 3.7 5.7 13.9 0.28 9.4 3.6 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF4698 PF15769.5 CDI86678.1 - 3.8 6.5 21.8 2.8 6.9 9.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4698) Serinc PF03348.15 CDI86678.1 - 3.9 6.3 18.5 1 8.2 9.7 2.2 2 0 0 2 2 2 0 Serine incorporator (Serinc) MMM1 PF10296.9 CDI86678.1 - 4.9 6.1 13.9 1.2 8.1 5.7 2.2 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 TFB6 PF17110.5 CDI86678.1 - 6 6.6 16.8 1.1 9.0 7.1 2.3 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF3381 PF11861.8 CDI86678.1 - 7 6.4 34.5 1.2 8.9 18.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) DUF5523 PF17661.1 CDI86678.1 - 7.6 6.1 27.8 1.8 8.2 14.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Chromo PF00385.24 CDI86680.1 - 4e-13 49.0 0.0 8.5e-13 48.0 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDI86680.1 - 0.049 13.4 0.2 0.22 11.3 0.1 2.2 2 0 0 2 2 2 0 Integrase core domain RVT_1 PF00078.27 CDI86681.1 - 1.6e-12 47.5 0.0 2.6e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 CDI86681.1 - 2e-08 34.1 0.0 3.6e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CDI86681.1 - 1.3e-07 32.1 0.0 3.4e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI86681.1 - 5.4e-07 30.1 0.0 1.1e-06 29.1 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RT_RNaseH_2 PF17919.1 CDI86681.1 - 2.7e-06 27.3 0.0 5.4e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-CCHC PF00098.23 CDI86682.1 - 0.0018 18.2 6.3 0.37 11.0 0.4 2.4 2 0 0 2 2 2 2 Zinc knuckle KASH_CCD PF14662.6 CDI86683.1 - 0.037 13.9 0.1 0.047 13.5 0.1 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Pkinase PF00069.25 CDI86685.1 - 2.7e-32 112.2 0.0 2.7e-32 112.2 0.0 4.1 3 2 0 3 3 3 1 Protein kinase domain DUF755 PF05501.11 CDI86685.1 - 0.0062 16.8 13.7 0.0062 16.8 13.7 15.7 11 4 2 14 14 14 1 Domain of unknown function (DUF755) Secretin_N_2 PF07655.13 CDI86686.1 - 2 9.0 23.7 6.2 7.4 17.7 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain PP2C PF00481.21 CDI86688.1 - 0.00087 19.0 1.1 0.0011 18.7 1.1 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C Spt20 PF12090.8 CDI86688.1 - 0.0023 17.6 18.9 0.0025 17.4 18.9 1.1 1 0 0 1 1 1 1 Spt20 family Roughex PF06020.11 CDI86688.1 - 0.003 16.7 4.6 0.003 16.7 4.6 1.1 1 0 0 1 1 1 1 Drosophila roughex protein Activator_LAG-3 PF11498.8 CDI86688.1 - 0.0069 15.4 17.8 0.0071 15.4 17.8 1.2 1 0 0 1 1 1 1 Transcriptional activator LAG-3 LIM_bind PF01803.16 CDI86688.1 - 0.029 13.9 2.3 0.032 13.7 2.3 1.1 1 0 0 1 1 1 0 LIM-domain binding protein eIF-3_zeta PF05091.12 CDI86688.1 - 0.068 12.1 7.2 0.069 12.1 7.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI86688.1 - 0.091 12.7 17.5 0.097 12.7 17.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI86688.1 - 0.11 12.5 7.6 0.11 12.4 7.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Menin PF05053.13 CDI86688.1 - 0.2 10.0 7.2 0.19 10.0 7.2 1.0 1 0 0 1 1 1 0 Menin ALMT PF11744.8 CDI86688.1 - 0.54 9.0 5.1 0.56 9.0 5.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter TERB2 PF15101.6 CDI86688.1 - 0.65 10.0 9.3 1.1 9.3 8.8 1.6 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DDHD PF02862.17 CDI86688.1 - 0.85 9.7 7.4 0.92 9.6 7.4 1.1 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 CDI86688.1 - 1 8.0 5.1 1.1 8.0 5.1 1.1 1 0 0 1 1 1 0 Presenilin BRF1 PF07741.13 CDI86688.1 - 1.1 9.7 7.1 1.5 9.2 7.1 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain UPF0524 PF15823.5 CDI86688.1 - 3.2 7.1 10.1 3.3 7.0 3.5 2.0 1 1 0 2 2 2 0 UPF0524 of C3orf70 SWI-SNF_Ssr4 PF08549.10 CDI86689.1 - 1.2 7.7 45.6 1.5 7.4 45.6 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Macoilin PF09726.9 CDI86690.1 - 0.006 15.2 11.2 0.0078 14.8 11.2 1.3 1 0 0 1 1 1 1 Macoilin family DUF572 PF04502.13 CDI86690.1 - 0.16 11.6 12.0 0.18 11.4 12.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Neur_chan_memb PF02932.16 CDI86690.1 - 2 8.4 5.6 2.8 7.9 5.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AF-4 PF05110.13 CDI86690.1 - 4.3 5.3 24.5 5.1 5.0 24.5 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Utp14 PF04615.13 CDI86690.1 - 5 5.6 17.8 5.9 5.3 17.8 1.0 1 0 0 1 1 1 0 Utp14 protein Apt1 PF10351.9 CDI86690.1 - 5.8 5.6 15.2 7.4 5.3 15.2 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ndc1_Nup PF09531.10 CDI86690.1 - 8.4 5.0 10.7 9.5 4.8 10.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HSD3 PF15244.6 CDI86690.1 - 8.5 5.8 12.7 11 5.4 12.7 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 ArsA_ATPase PF02374.15 CDI86691.1 - 1.7e-37 129.3 0.0 2e-37 129.1 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 CDI86691.1 - 1.1e-10 41.7 0.1 1.6e-10 41.2 0.1 1.4 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 CDI86691.1 - 3.8e-10 39.9 0.0 4e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 CDI86691.1 - 1.8e-06 27.6 0.0 2.3e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 CDI86691.1 - 3.6e-05 23.3 0.1 5.7e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 CDI86691.1 - 0.00085 18.9 0.0 0.0011 18.5 0.0 1.1 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ NB-ARC PF00931.22 CDI86691.1 - 0.0014 17.9 0.0 0.0014 17.9 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain SRP54 PF00448.22 CDI86691.1 - 0.0016 18.2 0.1 0.0022 17.6 0.1 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 CDI86691.1 - 0.0026 17.1 0.0 0.0034 16.7 0.0 1.1 1 0 0 1 1 1 1 Zeta toxin APS_kinase PF01583.20 CDI86691.1 - 0.021 14.7 0.0 0.032 14.1 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase T2SSE PF00437.20 CDI86691.1 - 0.043 12.9 0.1 0.056 12.5 0.1 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein VirC1 PF07015.11 CDI86691.1 - 0.047 13.0 0.0 0.071 12.4 0.0 1.2 1 0 0 1 1 1 0 VirC1 protein AAA_16 PF13191.6 CDI86691.1 - 0.051 14.0 0.0 0.053 13.9 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 CDI86691.1 - 0.053 13.4 0.6 0.12 12.3 0.6 1.5 1 1 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 CDI86691.1 - 0.058 13.9 0.0 0.065 13.7 0.0 1.1 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 CDI86691.1 - 0.062 13.8 0.0 0.075 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CDI86691.1 - 0.085 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein ResIII PF04851.15 CDI86691.1 - 0.13 12.3 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DnaB_C PF03796.15 CDI86691.1 - 0.14 11.5 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain PIF1 PF05970.14 CDI86691.1 - 0.18 10.9 0.0 0.26 10.4 0.0 1.1 1 0 0 1 1 1 0 PIF1-like helicase AAA_25 PF13481.6 CDI86691.1 - 0.28 10.8 0.8 0.45 10.1 0.7 1.2 1 1 0 1 1 1 0 AAA domain Mitofilin PF09731.9 CDI86693.1 - 0.3 9.9 29.1 0.36 9.6 29.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein PTPRCAP PF15713.5 CDI86693.1 - 0.43 10.9 21.5 0.52 10.6 21.5 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Presenilin PF01080.17 CDI86693.1 - 0.62 8.8 24.9 0.62 8.8 24.9 1.1 1 0 0 1 1 1 0 Presenilin ABC2_membrane_2 PF12679.7 CDI86693.1 - 0.79 8.9 6.4 1 8.6 6.4 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein NPR3 PF03666.13 CDI86693.1 - 0.94 8.2 19.5 1.1 7.9 19.5 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 EBP50_C PF09007.11 CDI86693.1 - 1 10.4 16.3 1.2 10.1 16.3 1.3 1 0 0 1 1 1 0 EBP50, C-terminal CSG2 PF16965.5 CDI86693.1 - 1.2 8.0 10.6 1.3 7.9 10.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator NST1 PF13945.6 CDI86693.1 - 1.8 8.6 27.2 2.1 8.4 27.2 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator TFIIA PF03153.13 CDI86693.1 - 1.9 8.4 47.6 2.3 8.1 47.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ExbD PF02472.16 CDI86693.1 - 2.7 8.2 15.1 3.4 7.9 15.1 1.2 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR CCSAP PF15748.5 CDI86693.1 - 2.8 8.0 23.5 2.9 8.0 23.5 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Gti1_Pac2 PF09729.9 CDI86693.1 - 2.9 8.0 19.1 3.4 7.7 19.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family SpoIIP PF07454.11 CDI86693.1 - 3 7.2 20.0 4.1 6.8 20.0 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4050 PF13259.6 CDI86693.1 - 3.9 7.7 18.0 4.4 7.6 18.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) RAG1_imp_bd PF12560.8 CDI86693.1 - 4.2 6.8 17.2 4.5 6.7 17.2 1.1 1 0 0 1 1 1 0 RAG1 importin binding CDC45 PF02724.14 CDI86693.1 - 4.3 5.5 18.0 4.2 5.5 18.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 CDI86693.1 - 4.3 6.5 14.6 4.8 6.3 14.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Hid1 PF12722.7 CDI86693.1 - 4.4 5.3 22.7 4.5 5.3 22.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2370 PF10176.9 CDI86693.1 - 4.5 6.8 9.9 5.1 6.7 9.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Tim54 PF11711.8 CDI86693.1 - 5.2 5.7 16.8 6.1 5.5 16.8 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DDRGK PF09756.9 CDI86693.1 - 5.6 6.5 29.0 6.5 6.3 29.0 1.2 1 0 0 1 1 1 0 DDRGK domain Neur_chan_memb PF02932.16 CDI86693.1 - 5.6 7.0 20.5 5.9 6.9 20.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF775 PF05603.12 CDI86693.1 - 5.6 6.4 22.7 7.3 6.1 22.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) ALMT PF11744.8 CDI86693.1 - 5.8 5.6 18.9 6.2 5.5 18.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter eIF-3_zeta PF05091.12 CDI86693.1 - 5.9 5.8 26.3 6.4 5.6 26.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DAG_kinase_N PF14513.6 CDI86693.1 - 5.9 7.1 20.1 6.5 6.9 20.1 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus PPL5 PF18168.1 CDI86693.1 - 6.1 6.0 14.0 6.4 6.0 14.0 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Draxin PF15550.6 CDI86693.1 - 6.8 6.5 15.8 7.2 6.4 15.8 1.1 1 0 0 1 1 1 0 Draxin TT_ORF1 PF02956.14 CDI86693.1 - 7.2 5.2 14.9 7.2 5.2 14.9 1.0 1 0 0 1 1 1 0 TT viral orf 1 Band_3_cyto PF07565.13 CDI86693.1 - 7.2 6.3 20.1 9.2 6.0 20.1 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Velvet PF11754.8 CDI86693.1 - 9.2 6.1 17.9 10 6.0 17.9 1.3 1 0 0 1 1 1 0 Velvet factor DUF572 PF04502.13 CDI86693.1 - 9.3 5.8 21.8 10 5.7 21.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) CSRNP_N PF16019.5 CDI86693.1 - 9.4 6.1 19.3 13 5.6 19.3 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Peptidase_U57 PF05582.12 CDI86693.1 - 9.6 5.4 13.4 9.8 5.3 13.4 1.2 1 0 0 1 1 1 0 YabG peptidase U57 DUF755 PF05501.11 CDI86694.1 - 0.022 15.0 18.5 0.022 15.0 18.5 5.5 2 1 3 5 5 5 0 Domain of unknown function (DUF755) RAP1 PF07218.11 CDI86694.1 - 0.09 11.1 6.5 0.11 10.7 6.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF3464 PF11947.8 CDI86695.1 - 0.038 13.7 1.2 0.039 13.7 1.2 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 VIT1 PF01988.19 CDI86695.1 - 0.062 13.2 0.0 0.069 13.0 0.0 1.0 1 0 0 1 1 1 0 VIT family EIIBC-GUT_N PF03612.14 CDI86695.1 - 0.096 12.4 2.1 0.093 12.5 2.1 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Spt20 PF12090.8 CDI86695.1 - 0.22 11.1 25.1 0.22 11.1 25.1 1.1 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI86695.1 - 0.38 11.8 7.1 0.4 11.7 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TFIIA PF03153.13 CDI86695.1 - 0.53 10.2 21.8 0.51 10.3 21.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI86695.1 - 0.54 9.0 5.0 0.56 8.9 5.0 1.0 1 0 0 1 1 1 0 Presenilin DivIC PF04977.15 CDI86695.1 - 0.58 10.0 10.8 0.73 9.6 10.8 1.1 1 0 0 1 1 1 0 Septum formation initiator DUF4175 PF13779.6 CDI86695.1 - 0.72 7.7 15.9 0.7 7.7 15.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Orf78 PF06024.12 CDI86695.1 - 0.76 10.1 4.2 0.94 9.8 4.2 1.1 1 0 0 1 1 1 0 Orf78 (ac78) Pex14_N PF04695.13 CDI86695.1 - 1.4 9.5 13.6 1.5 9.4 13.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2722 PF10846.8 CDI86695.1 - 1.6 7.6 22.7 1.6 7.6 22.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF755 PF05501.11 CDI86696.1 - 0.019 15.3 35.2 0.019 15.3 35.2 4.4 1 1 2 3 3 3 0 Domain of unknown function (DUF755) RAP1 PF07218.11 CDI86696.1 - 0.14 10.4 12.4 0.19 10.0 12.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Spt20 PF12090.8 CDI86697.1 - 0.016 14.9 19.2 0.019 14.6 19.2 1.0 1 0 0 1 1 1 0 Spt20 family FTZ PF03867.14 CDI86697.1 - 0.081 12.5 13.1 0.099 12.2 13.1 1.0 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region DUF2722 PF10846.8 CDI86697.1 - 0.11 11.5 12.0 0.11 11.4 12.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI86697.1 - 0.6 10.0 17.7 0.66 9.9 17.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CDI86697.1 - 0.74 9.3 8.2 0.83 9.2 8.2 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4366 PF14283.6 CDI86697.1 - 3.4 7.7 8.8 4.2 7.4 8.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) BAF1_ABF1 PF04684.13 CDI86697.1 - 5.1 6.0 10.8 5.6 5.9 10.8 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF853 PF05872.12 CDI86697.1 - 6.1 5.3 9.5 6.7 5.2 9.5 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) RskA PF10099.9 CDI86698.1 - 8.2e-08 32.8 3.4 2.9e-05 24.4 0.0 11.4 1 1 4 7 7 7 3 Anti-sigma-K factor rskA Sin_N PF04801.13 CDI86698.1 - 0.012 14.8 0.7 0.012 14.8 0.7 6.9 2 2 3 5 5 5 0 Sin-like protein conserved region TraX PF05857.11 CDI86698.1 - 0.071 13.2 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 TraX protein DUF2135 PF09906.9 CDI86699.1 - 0.086 13.2 0.9 1.5 9.2 0.9 3.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2135) 7tm_2 PF00002.24 CDI86699.1 - 0.11 11.8 0.0 0.11 11.8 0.0 5.1 5 1 2 7 7 7 0 7 transmembrane receptor (Secretin family) RskA PF10099.9 CDI86699.1 - 0.22 11.8 0.0 0.22 11.8 0.0 11.8 2 2 8 10 10 10 0 Anti-sigma-K factor rskA Phos_pyr_kin PF08543.12 CDI86700.1 - 1.7e-06 27.6 0.0 1.7e-06 27.6 0.0 3.1 2 2 1 3 3 3 1 Phosphomethylpyrimidine kinase RskA PF10099.9 CDI86700.1 - 0.00039 20.8 59.5 0.29 11.4 20.5 5.1 2 1 1 4 4 4 3 Anti-sigma-K factor rskA MAP7 PF05672.11 CDI86700.1 - 0.0015 18.2 36.6 0.15 11.8 4.0 2.5 2 0 0 2 2 2 2 MAP7 (E-MAP-115) family CDC45 PF02724.14 CDI86700.1 - 0.11 10.8 12.9 0.78 8.0 10.8 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF4199 PF13858.6 CDI86700.1 - 0.15 12.4 12.2 2 8.8 0.7 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF4199) DUF908 PF06012.12 CDI86700.1 - 0.47 9.8 16.6 2.2 7.6 11.4 2.9 3 0 0 3 3 3 0 Domain of Unknown Function (DUF908) Spore_YhcN_YlaJ PF09580.10 CDI86700.1 - 0.89 9.6 0.0 0.89 9.6 0.0 2.9 2 1 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF5523 PF17661.1 CDI86700.1 - 1 9.0 22.2 3.5 7.2 14.2 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5523) CBP4 PF07960.11 CDI86700.1 - 2.3 8.1 22.5 0.2 11.5 10.5 2.3 2 0 0 2 2 2 0 CBP4 CAF1 PF04857.20 CDI86700.1 - 3.2 6.8 15.1 3.6 6.7 0.0 2.2 2 0 0 2 2 2 0 CAF1 family ribonuclease FCP1_C PF09309.10 CDI86700.1 - 3.4 7.5 21.1 2.4 8.0 12.6 2.6 2 0 0 2 2 2 0 FCP1, C-terminal V_ATPase_I PF01496.19 CDI86700.1 - 3.9 5.3 19.9 1 7.2 12.3 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family FAM60A PF15396.6 CDI86700.1 - 7.7 6.5 18.4 18 5.2 14.2 2.5 3 0 0 3 3 3 0 Protein Family FAM60A RskA PF10099.9 CDI86701.1 - 0.0023 18.3 8.6 0.0026 18.1 8.6 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI86701.1 - 0.0064 16.1 8.5 0.0079 15.8 8.5 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Mucin PF01456.17 CDI86701.1 - 0.028 14.4 3.0 0.028 14.4 3.0 2.0 1 1 1 2 2 2 0 Mucin-like glycoprotein Plasmid_RAQPRD PF09686.10 CDI86702.1 - 0.04 14.1 1.8 0.04 14.1 1.8 1.9 2 1 0 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) DUF1631 PF07793.11 CDI86702.1 - 0.59 8.5 12.2 0.67 8.3 12.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) CCDC53 PF10152.9 CDI86702.1 - 0.68 10.3 3.9 0.85 10.0 3.9 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex SOSSC PF15925.5 CDI86702.1 - 1.5 10.2 5.9 2 9.8 5.9 1.2 1 0 0 1 1 1 0 SOSS complex subunit C DUF1180 PF06679.12 CDI86702.1 - 1.7 9.0 9.0 1.9 8.8 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) RskA PF10099.9 CDI86703.1 - 0.0065 16.8 11.9 0.0065 16.8 11.9 11.2 4 3 3 9 9 9 5 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI86705.1 - 0.3 10.7 20.9 0.53 9.9 20.9 1.4 1 0 0 1 1 1 0 Spt20 family Spt20 PF12090.8 CDI86706.1 - 6.9e-05 22.6 18.9 6.9e-05 22.6 18.9 3.7 3 1 0 3 3 3 2 Spt20 family DUF2722 PF10846.8 CDI86706.1 - 0.0028 16.7 18.1 0.0028 16.7 18.1 3.8 3 1 0 3 3 3 2 Protein of unknown function (DUF2722) Phostensin_N PF13916.6 CDI86706.1 - 0.065 13.6 0.5 0.065 13.6 0.5 5.7 4 2 0 4 4 4 0 PP1-regulatory protein, Phostensin N-terminal Peptidase_U4 PF03419.13 CDI86706.1 - 0.34 10.1 1.0 0.91 8.8 1.0 1.7 1 0 0 1 1 1 0 Sporulation factor SpoIIGA CLN3 PF02487.17 CDI86706.1 - 1 8.4 9.1 0.43 9.6 1.0 2.6 3 0 0 3 3 3 0 CLN3 protein Topoisom_bac PF01131.20 CDI86707.1 - 3.5e-86 289.8 0.0 6.1e-84 282.4 0.0 2.2 1 1 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 CDI86707.1 - 8e-15 54.9 0.0 1.6e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 Toprim domain Nucleo_P87 PF07267.11 CDI86708.1 - 4.6 6.0 14.5 7.1 5.4 14.5 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 NPV_P10 PF05531.12 CDI86709.1 - 0.17 12.3 0.2 0.17 12.3 0.2 4.8 6 0 0 6 6 6 0 Nucleopolyhedrovirus P10 protein GAT PF03127.14 CDI86711.1 - 1.1 9.6 16.8 0.98 9.8 1.9 4.8 5 1 1 6 6 6 0 GAT domain ASFV_J13L PF05568.11 CDI86712.1 - 4.8 6.9 12.5 0.043 13.6 0.8 2.4 1 1 1 2 2 2 0 African swine fever virus J13L protein DSPc PF00782.20 CDI86713.1 - 0.0049 16.7 0.0 0.0072 16.2 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain SCAB_CC PF16712.5 CDI86714.1 - 0.072 12.9 0.5 0.11 12.4 0.2 1.4 1 1 0 1 1 1 0 Coiled-coil regions of plant-specific actin-binding protein TetR_C_1 PF02909.17 CDI86715.1 - 0.016 15.0 0.5 0.036 13.9 0.5 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Ada3 PF10198.9 CDI86716.1 - 0.024 14.8 6.3 0.034 14.3 6.3 1.3 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 Phage_Mu_Gam PF07352.12 CDI86716.1 - 0.026 14.4 4.6 0.026 14.4 4.6 1.4 1 1 0 1 1 1 0 Bacteriophage Mu Gam like protein SpoU_sub_bind PF08032.12 CDI86716.1 - 0.027 14.7 1.3 0.064 13.5 0.4 1.9 1 1 1 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding DUF4618 PF15397.6 CDI86716.1 - 0.028 13.9 12.2 0.035 13.5 12.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) BOP1NT PF08145.12 CDI86716.1 - 0.06 13.3 2.3 0.075 13.0 2.3 1.1 1 0 0 1 1 1 0 BOP1NT (NUC169) domain GlutR_dimer PF00745.20 CDI86716.1 - 0.2 12.1 8.2 0.29 11.6 8.2 1.3 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain USP8_interact PF08941.10 CDI86716.1 - 1.1 9.0 8.4 0.16 11.8 3.8 1.7 1 1 1 2 2 2 0 USP8 interacting ZapB PF06005.12 CDI86716.1 - 1.7 9.1 19.8 1.4 9.4 8.3 2.7 1 1 1 2 2 2 0 Cell division protein ZapB APG6_N PF17675.1 CDI86716.1 - 2.5 8.6 15.4 5 7.6 15.4 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region V_ATPase_I PF01496.19 CDI86716.1 - 3.4 5.5 8.6 4.1 5.2 8.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_6 PF13174.6 CDI86717.1 - 0.0023 18.5 0.3 5.6 7.8 0.1 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI86717.1 - 0.0031 18.2 0.4 9.7 7.3 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDI86717.1 - 0.05 13.7 7.9 0.83 9.9 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDI86717.1 - 0.13 12.6 3.0 1.2 9.5 0.3 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDI86717.1 - 0.15 12.4 6.7 2.2 8.6 0.3 4.5 3 2 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 CDI86717.1 - 0.27 11.6 2.8 1.6 9.1 0.1 3.3 3 0 0 3 3 3 0 PPR repeat TPR_19 PF14559.6 CDI86717.1 - 0.34 11.4 6.9 22 5.6 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat YgbA_NO PF11756.8 CDI86717.1 - 0.69 10.3 2.7 1.1 9.6 0.2 2.3 2 0 0 2 2 2 0 Nitrous oxide-stimulated promoter TPR_1 PF00515.28 CDI86717.1 - 6.5 6.7 8.6 1.1 9.2 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DcuA_DcuB PF03605.14 CDI86718.1 - 0.0027 16.7 0.6 0.0039 16.1 0.6 1.2 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter Jnk-SapK_ap_N PF09744.9 CDI86718.1 - 0.075 13.3 4.1 0.13 12.4 0.8 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 TrbC PF04956.13 CDI86719.1 - 0.73 10.1 9.8 4 7.7 5.4 3.3 3 0 0 3 3 3 0 TrbC/VIRB2 family Lzipper-MIP1 PF14389.6 CDI86720.1 - 0.013 15.8 0.2 0.013 15.8 0.2 3.5 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 ABC_ATPase PF09818.9 CDI86720.1 - 0.25 10.1 1.5 0.39 9.4 1.5 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class DUF1993 PF09351.10 CDI86720.1 - 1.2 9.3 4.7 1.3e+02 2.7 6.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1993) WD40 PF00400.32 CDI86721.1 - 0.14 13.1 0.8 2.5 9.1 0.0 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat RskA PF10099.9 CDI86722.1 - 0.0027 18.0 9.9 0.0027 18.0 9.9 17.1 5 4 7 12 12 12 2 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI86724.1 - 0.24 11.0 9.4 0.25 10.9 9.4 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDK2AP PF09806.9 CDI86724.1 - 0.76 9.8 14.6 0.82 9.7 14.6 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DUF1635 PF07795.11 CDI86724.1 - 3.9 7.3 13.1 5 6.9 13.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DUF4820 PF16091.5 CDI86724.1 - 4.8 6.5 10.7 5.2 6.4 10.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Tetraspanin PF00335.20 CDI86724.1 - 7.4 6.2 7.4 7.5 6.2 7.4 1.1 1 0 0 1 1 1 0 Tetraspanin family DUF4518 PF15008.6 CDI86725.1 - 0.0075 15.5 6.1 0.0083 15.3 6.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4518) DUF4834 PF16118.5 CDI86725.1 - 0.0076 17.2 3.7 0.0076 17.2 3.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) RNA_pol_Rbc25 PF08292.12 CDI86725.1 - 0.0097 16.1 2.5 0.011 15.9 2.5 1.0 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 Spt20 PF12090.8 CDI86725.1 - 0.012 15.3 20.6 0.013 15.2 20.6 1.1 1 0 0 1 1 1 0 Spt20 family Peptidase_S49_N PF08496.10 CDI86725.1 - 0.063 13.3 3.8 0.066 13.3 3.8 1.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Presenilin PF01080.17 CDI86725.1 - 0.066 12.0 2.4 0.06 12.1 2.4 1.1 1 0 0 1 1 1 0 Presenilin WRNPLPNID PF15017.6 CDI86725.1 - 0.13 13.1 3.5 0.18 12.7 3.5 1.1 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Zip PF02535.22 CDI86725.1 - 0.16 11.1 0.9 0.18 11.0 0.9 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2722 PF10846.8 CDI86725.1 - 0.69 8.8 20.1 0.7 8.8 20.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Med15 PF09606.10 CDI86725.1 - 0.85 8.2 19.3 0.85 8.2 19.3 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal EIIBC-GUT_N PF03612.14 CDI86725.1 - 0.99 9.1 5.3 1.1 9.0 5.3 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3464 PF11947.8 CDI86725.1 - 1.3 8.7 4.9 1.5 8.6 4.9 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 GTA_holin_3TM PF11351.8 CDI86725.1 - 2.5 8.7 5.7 2.8 8.5 5.7 1.1 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release TFIIA PF03153.13 CDI86725.1 - 2.5 8.0 21.0 2.6 7.9 21.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit UPF0560 PF10577.9 CDI86725.1 - 2.6 6.4 14.1 2.9 6.3 14.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Roughex PF06020.11 CDI86725.1 - 2.7 7.0 9.5 2.9 6.9 9.5 1.1 1 0 0 1 1 1 0 Drosophila roughex protein DUF4175 PF13779.6 CDI86725.1 - 3.7 5.3 18.5 4.1 5.2 18.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Activator_LAG-3 PF11498.8 CDI86725.1 - 4.7 6.1 34.2 5.2 5.9 34.2 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SUIM_assoc PF16619.5 CDI86725.1 - 8.7 6.5 32.3 4e+03 -2.0 32.3 2.2 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI86727.1 - 0.00035 20.7 27.4 0.00035 20.7 27.4 5.0 3 1 1 4 4 4 2 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI86727.1 - 0.00074 19.2 11.9 0.00074 19.2 11.9 8.2 4 2 4 8 8 8 2 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI86727.1 - 0.0031 17.5 3.4 0.0031 17.5 3.4 10.2 7 2 1 8 8 8 2 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI86727.1 - 0.0054 17.0 22.9 0.0054 17.0 22.9 9.0 2 2 5 7 7 7 3 Anti-sigma-K factor rskA DUF2052 PF09747.9 CDI86727.1 - 0.2 11.7 36.3 0.52 10.4 0.6 4.1 4 0 0 4 4 4 0 Coiled-coil domain containing protein (DUF2052) DUF2072 PF09845.9 CDI86727.1 - 1.8 8.8 28.2 0.65 10.3 0.7 4.0 3 0 0 3 3 3 0 Zn-ribbon containing protein eIF-3_zeta PF05091.12 CDI86727.1 - 3 6.7 56.6 0.29 10.0 18.2 3.3 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI86728.1 - 1.4e-05 24.1 33.8 1.7e-05 23.8 33.8 1.1 1 0 0 1 1 1 1 Presenilin PAT1 PF09770.9 CDI86728.1 - 0.00033 19.1 50.4 0.00034 19.0 50.4 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 CCSAP PF15748.5 CDI86728.1 - 0.002 18.4 33.4 0.0023 18.1 33.4 1.2 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated DUF4045 PF13254.6 CDI86728.1 - 0.0061 16.2 29.7 0.0068 16.1 29.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4045) SAGA-Tad1 PF12767.7 CDI86728.1 - 0.0063 16.3 25.5 0.0084 15.9 25.5 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit Lin-8 PF03353.15 CDI86728.1 - 0.026 14.1 35.0 0.037 13.6 35.0 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 CDI86728.1 - 0.026 12.8 28.7 0.031 12.6 28.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Hamartin PF04388.12 CDI86728.1 - 0.027 13.2 24.6 0.03 13.0 24.6 1.1 1 0 0 1 1 1 0 Hamartin protein SLC12 PF03522.15 CDI86728.1 - 0.04 12.9 32.2 0.046 12.7 32.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Draxin PF15550.6 CDI86728.1 - 0.089 12.7 17.9 0.11 12.4 17.9 1.2 1 0 0 1 1 1 0 Draxin ABC2_membrane_2 PF12679.7 CDI86728.1 - 0.11 11.7 0.0 0.11 11.7 0.0 2.3 1 1 1 2 2 1 0 ABC-2 family transporter protein Exonuc_VII_L PF02601.15 CDI86728.1 - 0.16 11.5 34.5 0.2 11.2 34.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit GREB1 PF15782.5 CDI86728.1 - 0.35 7.9 32.6 0.38 7.8 32.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOBP PF15279.6 CDI86728.1 - 0.39 11.3 31.7 0.49 11.0 31.7 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Apt1 PF10351.9 CDI86728.1 - 0.4 9.5 19.5 0.45 9.3 19.5 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain LAP1C PF05609.12 CDI86728.1 - 0.46 9.5 33.2 0.57 9.2 33.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) NPR3 PF03666.13 CDI86728.1 - 0.55 9.0 30.3 0.67 8.7 30.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ALMT PF11744.8 CDI86728.1 - 0.59 8.9 24.6 0.73 8.6 24.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter 2HCT PF03390.15 CDI86728.1 - 0.92 8.1 13.6 0.056 12.1 0.6 2.2 1 1 1 2 2 2 0 2-hydroxycarboxylate transporter family Dapper PF15268.6 CDI86728.1 - 1.1 8.0 36.4 1.3 7.8 36.4 1.0 1 0 0 1 1 1 0 Dapper Raftlin PF15250.6 CDI86728.1 - 1.7 7.3 27.3 2.1 7.0 27.3 1.1 1 0 0 1 1 1 0 Raftlin Spc7_N PF15402.6 CDI86728.1 - 1.7 6.8 31.7 2.6 6.2 31.7 1.2 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF1387 PF07139.11 CDI86728.1 - 2 8.1 31.5 3.4 7.3 31.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Tmp39 PF10271.9 CDI86728.1 - 2.4 7.1 5.2 2.8 6.8 5.2 1.1 1 0 0 1 1 1 0 Putative transmembrane protein MCM_bind PF09739.9 CDI86728.1 - 2.4 6.5 28.5 3.1 6.1 28.5 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor MAP7 PF05672.11 CDI86728.1 - 2.4 7.8 59.7 3.2 7.4 59.7 1.1 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family FAM60A PF15396.6 CDI86728.1 - 2.5 8.1 28.8 3.5 7.6 28.8 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF4551 PF15087.6 CDI86728.1 - 2.5 6.8 25.4 2.9 6.6 25.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF572 PF04502.13 CDI86728.1 - 2.6 7.6 30.7 3.4 7.2 30.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Peptidase_S64 PF08192.11 CDI86728.1 - 4.7 5.6 25.7 6.4 5.1 25.7 1.2 1 0 0 1 1 1 0 Peptidase family S64 MID_MedPIWI PF18296.1 CDI86728.1 - 5 6.8 37.6 0.037 13.8 15.0 2.0 1 1 1 2 2 1 0 MID domain of medPIWI PA26 PF04636.13 CDI86728.1 - 5.4 5.8 22.9 6.9 5.5 22.9 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SAPS PF04499.15 CDI86728.1 - 6.7 5.4 27.1 8.7 5.0 27.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ndc1_Nup PF09531.10 CDI86728.1 - 7.7 5.1 36.5 8.9 4.9 36.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Membralin PF09746.9 CDI86728.1 - 7.8 5.4 21.6 10 5.1 21.6 1.1 1 0 0 1 1 1 0 Tumour-associated protein EBP50_C PF09007.11 CDI86730.1 - 0.28 12.2 26.6 0.82 10.7 15.4 2.1 2 0 0 2 2 2 0 EBP50, C-terminal DUF1764 PF08576.10 CDI86730.1 - 0.72 10.8 35.6 2.6 9.0 8.7 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Pox_Ag35 PF03286.14 CDI86730.1 - 1.2 8.9 19.7 0.54 10.0 10.5 2.0 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Peptidase_S49_N PF08496.10 CDI86730.1 - 3.8 7.5 36.6 2.9 7.9 8.0 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal PTPRCAP PF15713.5 CDI86730.1 - 6.3 7.1 43.2 6.3 7.1 8.9 2.1 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated FYDLN_acid PF09538.10 CDI86730.1 - 7.5 7.3 25.7 9 7.0 3.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Zip PF02535.22 CDI86730.1 - 8.6 5.5 27.1 5.9 6.0 16.2 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter SAPS PF04499.15 CDI86730.1 - 9.6 4.9 29.2 15 4.2 29.2 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BC10 PF06726.12 CDI86731.1 - 0.22 11.8 1.6 0.57 10.5 1.6 1.7 1 0 0 1 1 1 0 Bladder cancer-related protein BC10 CLP1_P PF16575.5 CDI86732.1 - 1e-07 32.0 0.4 1.3e-06 28.3 0.1 3.8 3 2 0 3 3 3 2 mRNA cleavage and polyadenylation factor CLP1 P-loop RskA PF10099.9 CDI86732.1 - 7.4e-06 26.4 2.4 7.4e-06 26.4 2.4 6.2 2 1 3 5 5 5 3 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI86732.1 - 0.0097 15.5 1.6 0.0097 15.5 1.6 5.9 5 1 0 5 5 5 2 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI86732.1 - 0.011 15.4 5.8 0.011 15.4 5.8 4.7 4 1 0 4 4 4 0 Spt20 family MAM33 PF02330.16 CDI86732.1 - 0.017 15.1 33.1 0.23 11.4 6.0 4.3 4 0 0 4 4 4 0 Mitochondrial glycoprotein FAM101 PF15068.6 CDI86732.1 - 0.083 12.8 0.2 0.083 12.8 0.2 5.8 5 2 1 6 6 6 0 FAM101 family DUF4834 PF16118.5 CDI86732.1 - 2.4 9.2 59.9 0.11 13.5 6.9 5.4 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) EPL1 PF10513.9 CDI86732.1 - 3.5 8.0 49.5 1.3 9.4 9.7 5.2 5 0 0 5 5 5 0 Enhancer of polycomb-like RskA PF10099.9 CDI86733.1 - 0.0097 16.2 0.5 0.01 16.1 0.5 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Herpes_IE68 PF02479.16 CDI86733.1 - 0.015 14.9 0.8 0.024 14.2 0.7 1.4 1 1 0 1 1 1 0 Herpesvirus immediate early protein TFIIA PF03153.13 CDI86733.1 - 0.015 15.3 29.8 0.018 15.1 29.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI86733.1 - 0.065 11.8 36.9 0.073 11.6 36.9 1.0 1 0 0 1 1 1 0 Macoilin family Roughex PF06020.11 CDI86733.1 - 0.28 10.2 15.1 0.35 9.9 15.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Miga PF10265.9 CDI86733.1 - 0.47 9.4 27.3 0.5 9.3 27.3 1.0 1 0 0 1 1 1 0 Mitoguardin Nop25 PF09805.9 CDI86733.1 - 0.48 10.9 11.0 0.67 10.4 11.0 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) PNISR PF15996.5 CDI86733.1 - 0.67 10.2 22.4 0.8 9.9 22.4 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR PI3K_1B_p101 PF10486.9 CDI86733.1 - 0.76 7.5 21.7 0.9 7.2 21.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SKA1 PF07160.12 CDI86733.1 - 1 9.1 15.1 1.3 8.8 15.1 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF4175 PF13779.6 CDI86733.1 - 1.4 6.7 18.4 1.4 6.7 18.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF2052 PF09747.9 CDI86733.1 - 1.4 9.0 14.0 1.7 8.7 14.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SPX PF03105.19 CDI86733.1 - 2 8.3 33.6 2.2 8.1 33.6 1.0 1 0 0 1 1 1 0 SPX domain MAT1 PF06391.13 CDI86733.1 - 3.3 7.5 19.4 4.2 7.1 19.4 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 SURF6 PF04935.12 CDI86733.1 - 3.4 7.4 17.5 5 6.9 17.5 1.2 1 0 0 1 1 1 0 Surfeit locus protein 6 SLC12 PF03522.15 CDI86733.1 - 4.5 6.2 23.7 5.3 5.9 23.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF3807 PF12720.7 CDI86733.1 - 4.7 7.4 22.5 6.4 7.0 22.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Presenilin PF01080.17 CDI86733.1 - 5.1 5.8 28.1 6.2 5.5 28.1 1.1 1 0 0 1 1 1 0 Presenilin DUF1180 PF06679.12 CDI86733.1 - 5.5 7.4 21.7 13 6.1 21.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) Utp14 PF04615.13 CDI86733.1 - 8.6 4.8 22.1 9.5 4.6 22.1 1.0 1 0 0 1 1 1 0 Utp14 protein RskA PF10099.9 CDI86735.1 - 0.034 14.4 25.4 0.045 14.1 25.4 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Med3 PF11593.8 CDI86735.1 - 0.17 11.1 36.4 0.21 10.7 36.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal CDC27 PF09507.10 CDI86735.1 - 0.85 8.9 25.1 1.1 8.6 25.1 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Hamartin PF04388.12 CDI86735.1 - 1.3 7.6 15.0 1.5 7.4 15.0 1.0 1 0 0 1 1 1 0 Hamartin protein TFIIA PF03153.13 CDI86735.1 - 1.8 8.4 31.1 2.4 8.1 31.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Myc_N PF01056.18 CDI86735.1 - 2.4 8.0 14.7 2.8 7.8 14.7 1.0 1 0 0 1 1 1 0 Myc amino-terminal region Med15 PF09606.10 CDI86735.1 - 3 6.4 30.1 3.7 6.1 30.1 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4813 PF16072.5 CDI86735.1 - 3.4 7.3 27.9 4.2 6.9 27.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) ApoLp-III PF07464.11 CDI86736.1 - 0.35 11.0 6.4 1.6 8.8 6.4 1.8 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) CCDC53 PF10152.9 CDI86736.1 - 0.95 9.9 5.1 1.2 9.5 5.1 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF4404 PF14357.6 CDI86736.1 - 1.3 9.7 7.6 0.33 11.6 3.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF2229 PF09989.9 CDI86736.1 - 1.5 8.4 4.9 1.9 8.1 4.9 1.1 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) GTA_holin_3TM PF11351.8 CDI86736.1 - 4 8.0 13.1 14 6.3 13.1 1.8 1 1 0 1 1 1 0 Holin of 3TMs, for gene-transfer release RIFIN PF02009.16 CDI86736.1 - 4.3 7.1 5.3 5 6.9 5.3 1.1 1 0 0 1 1 1 0 Rifin Nop53 PF07767.11 CDI86737.1 - 0.0039 16.6 12.1 0.0051 16.3 12.1 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) BSP_II PF05432.11 CDI86737.1 - 0.26 11.0 8.2 0.36 10.5 8.2 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) baeRF_family12 PF18856.1 CDI86737.1 - 0.35 11.5 3.8 0.54 10.8 3.8 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 Pex14_N PF04695.13 CDI86737.1 - 4.2 8.0 13.7 0.88 10.2 9.2 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt5_N PF11942.8 CDI86737.1 - 8.2 7.5 11.8 22 6.1 11.8 1.7 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal bMG10 PF17973.1 CDI86739.1 - 6.4 7.0 10.1 0.26 11.5 2.8 2.4 3 0 0 3 3 3 0 Bacterial Alpha-2-macroglobulin MG10 domain DDRGK PF09756.9 CDI86740.1 - 0.02 14.5 29.4 0.023 14.3 29.4 1.1 1 0 0 1 1 1 0 DDRGK domain Tim54 PF11711.8 CDI86740.1 - 0.11 11.2 19.9 0.12 11.2 19.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Plasmodium_Vir PF05795.11 CDI86740.1 - 0.23 10.8 16.4 0.26 10.7 16.4 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein eIF-3_zeta PF05091.12 CDI86740.1 - 0.29 10.0 34.8 0.35 9.8 34.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Gti1_Pac2 PF09729.9 CDI86740.1 - 1.5 8.9 25.0 1.8 8.6 25.0 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF1387 PF07139.11 CDI86740.1 - 2 8.0 29.4 2.5 7.7 29.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Spore_coat_CotO PF14153.6 CDI86740.1 - 2.2 8.2 30.9 2.9 7.8 30.9 1.3 1 0 0 1 1 1 0 Spore coat protein CotO PPL5 PF18168.1 CDI86740.1 - 2.7 7.2 17.7 3.3 6.9 17.7 1.3 1 0 0 1 1 1 0 Prim-pol family 5 DUF4638 PF15472.6 CDI86740.1 - 2.8 7.6 22.9 3.3 7.4 22.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) MCM_bind PF09739.9 CDI86740.1 - 3.1 6.1 26.3 3.2 6.1 26.3 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor TFIIA PF03153.13 CDI86740.1 - 3.1 7.7 54.6 4.3 7.2 54.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4746 PF15928.5 CDI86740.1 - 3.3 7.0 22.7 3.6 6.9 22.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) AF-4 PF05110.13 CDI86740.1 - 3.5 5.6 34.1 3.7 5.5 34.1 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4045 PF13254.6 CDI86740.1 - 3.5 7.2 23.6 3.7 7.1 23.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) ALMT PF11744.8 CDI86740.1 - 3.5 6.4 25.0 4.1 6.1 25.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Peptidase_S64 PF08192.11 CDI86740.1 - 4 5.8 27.1 4.6 5.6 27.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Endostatin PF06482.11 CDI86740.1 - 4.1 6.8 25.4 4.4 6.7 25.4 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CCDC53 PF10152.9 CDI86740.1 - 4.5 7.7 24.8 6.4 7.2 24.8 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Macoilin PF09726.9 CDI86740.1 - 5.6 5.4 27.9 6.6 5.2 27.9 1.0 1 0 0 1 1 1 0 Macoilin family Bul1_N PF04425.12 CDI86740.1 - 6.1 5.5 29.9 6.9 5.3 29.9 1.0 1 0 0 1 1 1 0 Bul1 N terminus RR_TM4-6 PF06459.12 CDI86740.1 - 6.4 6.5 30.7 7.1 6.4 30.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CLN3 PF02487.17 CDI86740.1 - 6.5 5.7 20.7 8.3 5.3 20.7 1.3 1 0 0 1 1 1 0 CLN3 protein PAT1 PF09770.9 CDI86740.1 - 7.2 4.7 45.2 7.8 4.6 45.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Spc7_N PF15402.6 CDI86740.1 - 7.2 4.7 23.6 8.5 4.5 23.6 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Membralin PF09746.9 CDI86740.1 - 7.3 5.5 24.4 8.5 5.3 24.4 1.0 1 0 0 1 1 1 0 Tumour-associated protein eIF3_subunit PF08597.10 CDI86740.1 - 7.5 6.4 24.6 8.9 6.1 24.6 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Presenilin PF01080.17 CDI86740.1 - 7.6 5.2 35.7 8.1 5.1 35.7 1.0 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI86740.1 - 7.6 5.4 32.6 8.1 5.3 32.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI86740.1 - 7.7 6.5 23.8 8 6.4 23.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NST1 PF13945.6 CDI86740.1 - 8.1 6.5 43.2 12 6.0 43.2 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF3402 PF11882.8 CDI86741.1 - 0.0034 16.6 0.3 0.0073 15.5 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) SUIM_assoc PF16619.5 CDI86741.1 - 0.0065 16.5 2.4 0.0065 16.5 2.4 2.3 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Vitelline_membr PF10542.9 CDI86741.1 - 1.9 8.4 10.7 1.4 8.8 4.3 2.6 2 0 0 2 2 2 0 Vitelline membrane cysteine-rich region RNA_pol_Rpb1_5 PF04998.17 CDI86742.1 - 4.1e-05 23.2 63.4 0.01 15.3 63.4 2.8 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 Asparaginase_2 PF01112.18 CDI86742.1 - 0.016 14.3 0.3 0.016 14.3 0.3 4.5 2 1 1 3 3 3 0 Asparaginase Utp14 PF04615.13 CDI86742.1 - 0.058 12.0 64.6 0.053 12.1 58.8 2.0 2 0 0 2 2 2 0 Utp14 protein DUF572 PF04502.13 CDI86742.1 - 0.11 12.1 57.1 0.11 12.1 50.9 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) Cwf_Cwc_15 PF04889.12 CDI86743.1 - 0.51 10.0 39.4 0.6 9.8 39.4 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF4746 PF15928.5 CDI86743.1 - 2.3 7.6 40.6 3.8 6.8 40.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FCP1_C PF09309.10 CDI86743.1 - 3.2 7.6 37.1 4.1 7.2 37.1 1.1 1 0 0 1 1 1 0 FCP1, C-terminal SR-25 PF10500.9 CDI86744.1 - 0.00051 19.7 0.8 0.00057 19.6 0.8 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Myb_Cef PF11831.8 CDI86744.1 - 0.0055 16.3 5.3 0.0062 16.1 5.3 1.0 1 0 0 1 1 1 1 pre-mRNA splicing factor component FAM176 PF14851.6 CDI86744.1 - 0.017 14.8 1.4 0.019 14.6 1.4 1.1 1 0 0 1 1 1 0 FAM176 family TRAP_alpha PF03896.16 CDI86744.1 - 0.037 13.2 0.5 0.04 13.1 0.5 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit THOC2_N PF16134.5 CDI86744.1 - 0.045 12.4 1.7 0.045 12.4 1.7 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus DUF913 PF06025.12 CDI86744.1 - 0.052 12.5 1.2 0.055 12.5 1.2 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 CDI86744.1 - 0.065 13.2 3.2 0.072 13.1 3.2 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Coilin_N PF15862.5 CDI86744.1 - 0.071 12.9 4.6 0.083 12.7 4.6 1.1 1 0 0 1 1 1 0 Coilin N-terminus Pex14_N PF04695.13 CDI86744.1 - 0.092 13.4 7.1 0.1 13.2 7.1 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CPSF100_C PF13299.6 CDI86744.1 - 0.14 12.4 2.1 0.14 12.3 2.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF5421 PF17458.2 CDI86744.1 - 0.15 11.5 9.0 0.16 11.4 9.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5421) Spt20 PF12090.8 CDI86744.1 - 0.21 11.2 17.2 0.23 11.0 17.2 1.1 1 0 0 1 1 1 0 Spt20 family GOLD_2 PF13897.6 CDI86744.1 - 0.26 11.8 0.9 0.29 11.6 0.9 1.1 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking ERF PF04404.12 CDI86744.1 - 0.27 11.1 8.7 0.33 10.8 8.7 1.1 1 0 0 1 1 1 0 ERF superfamily PepSY_2 PF13670.6 CDI86744.1 - 0.29 11.2 3.9 0.37 10.8 3.9 1.2 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain EOS1 PF12326.8 CDI86744.1 - 0.32 10.9 1.7 0.36 10.7 1.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein Conotoxin PF02950.17 CDI86744.1 - 0.54 11.3 4.7 0.69 11.0 4.7 1.2 1 0 0 1 1 1 0 Conotoxin DUF3464 PF11947.8 CDI86744.1 - 0.63 9.8 3.4 0.7 9.6 3.4 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Med3 PF11593.8 CDI86744.1 - 0.74 8.9 14.2 0.86 8.7 14.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF2722 PF10846.8 CDI86744.1 - 0.87 8.5 16.5 0.95 8.3 16.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Androgen_recep PF02166.16 CDI86744.1 - 1.6 7.5 16.5 1.8 7.3 16.5 1.1 1 0 0 1 1 1 0 Androgen receptor Presenilin PF01080.17 CDI86744.1 - 2.4 6.8 6.6 2.6 6.7 6.6 1.1 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 CDI86744.1 - 4.6 6.2 11.1 4.8 6.2 11.1 1.1 1 0 0 1 1 1 0 Drosophila roughex protein DUF4834 PF16118.5 CDI86744.1 - 6.8 7.7 8.1 8.4 7.4 8.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Exonuc_VII_L PF02601.15 CDI86746.1 - 2.1 7.8 40.5 0.83 9.2 29.6 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit PAT1 PF09770.9 CDI86746.1 - 5.7 5.1 54.1 0.4 8.9 45.9 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF4407 PF14362.6 CDI86747.1 - 0.00016 21.2 17.5 0.00027 20.4 17.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Pex14_N PF04695.13 CDI86747.1 - 0.00023 21.9 27.0 0.0004 21.1 20.4 2.3 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PAT1 PF09770.9 CDI86747.1 - 0.0003 19.2 18.3 0.0003 19.2 18.3 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Macoilin PF09726.9 CDI86747.1 - 0.00087 18.0 20.2 0.0011 17.7 20.2 1.1 1 0 0 1 1 1 1 Macoilin family DUF2722 PF10846.8 CDI86747.1 - 0.0026 16.8 28.6 0.0026 16.8 28.6 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) API5 PF05918.11 CDI86747.1 - 0.0046 15.8 11.1 0.0058 15.5 11.1 1.2 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) ECM1 PF05782.11 CDI86747.1 - 0.011 14.7 8.9 0.011 14.8 8.9 1.1 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) Connexin PF00029.19 CDI86747.1 - 0.012 15.4 3.9 0.016 15.0 3.9 1.3 1 0 0 1 1 1 0 Connexin Med15 PF09606.10 CDI86747.1 - 0.012 14.4 28.3 0.012 14.4 28.3 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SPX PF03105.19 CDI86747.1 - 0.014 15.4 24.5 0.019 14.9 24.5 1.2 1 0 0 1 1 1 0 SPX domain eIF-3_zeta PF05091.12 CDI86747.1 - 0.065 12.2 17.0 0.088 11.8 17.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Utp14 PF04615.13 CDI86747.1 - 0.066 11.8 17.9 0.082 11.5 17.9 1.1 1 0 0 1 1 1 0 Utp14 protein TRAP_alpha PF03896.16 CDI86747.1 - 0.14 11.3 8.3 10 5.2 10.4 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Sec62 PF03839.16 CDI86747.1 - 0.15 11.5 6.8 0.21 11.1 6.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 HCO3_cotransp PF00955.21 CDI86747.1 - 0.3 9.8 3.7 0.44 9.3 3.7 1.2 1 0 0 1 1 1 0 HCO3- transporter family Suf PF05843.14 CDI86747.1 - 0.37 10.7 19.7 0.033 14.2 15.4 1.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Scs3p PF10261.9 CDI86747.1 - 0.42 10.1 1.6 0.66 9.4 1.6 1.4 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM MMR1 PF08505.10 CDI86747.1 - 0.5 10.6 27.8 0.026 14.8 18.9 1.9 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Lin-8 PF03353.15 CDI86747.1 - 0.54 9.8 27.2 0.12 11.9 21.3 1.9 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist TFIIA PF03153.13 CDI86747.1 - 0.58 10.1 50.9 1 9.3 50.9 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Folate_carrier PF01770.18 CDI86747.1 - 0.66 8.6 4.8 0.86 8.3 4.8 1.3 1 0 0 1 1 1 0 Reduced folate carrier CLN3 PF02487.17 CDI86747.1 - 0.7 8.9 9.6 1.1 8.2 9.6 1.3 1 0 0 1 1 1 0 CLN3 protein SpoIIP PF07454.11 CDI86747.1 - 0.73 9.2 16.8 0.068 12.6 12.6 1.4 2 0 0 2 2 1 0 Stage II sporulation protein P (SpoIIP) AAT PF03417.16 CDI86747.1 - 0.94 9.1 9.8 1.4 8.5 9.8 1.3 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Peptidase_U57 PF05582.12 CDI86747.1 - 1.4 8.2 9.2 1.8 7.7 9.2 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Paramyxo_ncap PF00973.19 CDI86747.1 - 1.4 7.8 8.8 2 7.2 8.8 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Eapp_C PF10238.9 CDI86747.1 - 1.8 8.7 17.0 0.087 12.9 11.0 1.9 2 0 0 2 2 2 0 E2F-associated phosphoprotein Tim54 PF11711.8 CDI86747.1 - 2.1 7.1 16.3 0.19 10.5 11.5 1.6 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Ureide_permease PF07168.11 CDI86747.1 - 2.2 6.9 5.8 3.4 6.3 5.8 1.4 1 0 0 1 1 1 0 Ureide permease TFB6 PF17110.5 CDI86747.1 - 2.6 7.7 8.3 0.3 10.8 4.2 1.6 2 0 0 2 2 1 0 Subunit 11 of the general transcription factor TFIIH LMBR1 PF04791.16 CDI86747.1 - 2.9 6.7 6.0 3.7 6.4 6.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Plasmodium_Vir PF05795.11 CDI86747.1 - 3.6 6.9 15.8 6.4 6.1 15.7 1.3 1 1 0 1 1 1 0 Plasmodium vivax Vir protein tRNA-synt_2c PF01411.19 CDI86747.1 - 3.8 5.9 9.2 4.8 5.6 9.2 1.1 1 0 0 1 1 1 0 tRNA synthetases class II (A) Membralin PF09746.9 CDI86747.1 - 4 6.4 7.4 5.4 6.0 7.4 1.2 1 0 0 1 1 1 0 Tumour-associated protein FliP PF00813.20 CDI86747.1 - 4.1 7.2 4.2 5.4 6.9 4.2 1.2 1 0 0 1 1 1 0 FliP family DUF4746 PF15928.5 CDI86747.1 - 4.1 6.7 10.6 5.8 6.2 10.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4770 PF15994.5 CDI86747.1 - 4.2 7.6 15.9 6.6 6.9 15.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Spore_coat_CotO PF14153.6 CDI86747.1 - 4.2 7.3 27.4 7.2 6.5 27.4 1.4 1 0 0 1 1 1 0 Spore coat protein CotO PA26 PF04636.13 CDI86747.1 - 5.3 5.9 13.9 9.1 5.1 13.9 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) EMC3_TMCO1 PF01956.16 CDI86747.1 - 6.4 6.5 9.3 8 6.2 9.3 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like MARCKS PF02063.17 CDI86747.1 - 6.6 6.6 33.1 0.15 12.0 26.5 1.5 2 0 0 2 2 1 0 MARCKS family Hydin_ADK PF17213.3 CDI86747.1 - 7.8 6.7 24.8 0.81 9.9 17.5 2.0 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain DUF3408 PF11888.8 CDI86747.1 - 8.3 6.6 17.7 1.4 9.1 13.9 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF3408) DUF1764 PF08576.10 CDI86747.1 - 9.3 7.2 15.0 1.4 9.9 10.2 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) V_ATPase_I PF01496.19 CDI86747.1 - 9.9 3.9 16.1 13 3.5 16.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AF-4 PF05110.13 CDI86748.1 - 0.48 8.4 53.9 0.73 7.9 53.9 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SPX PF03105.19 CDI86749.1 - 1.8 8.4 10.1 3.1 7.6 10.1 1.4 1 1 0 1 1 1 0 SPX domain Activator_LAG-3 PF11498.8 CDI86749.1 - 3.5 6.5 35.8 0.19 10.7 15.9 2.4 2 0 0 2 2 2 0 Transcriptional activator LAG-3 RAP1 PF07218.11 CDI86750.1 - 0.24 9.7 14.7 0.26 9.5 14.7 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF3523 PF12037.8 CDI86750.1 - 0.5 9.7 23.2 0.54 9.6 23.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) RSRP PF17069.5 CDI86750.1 - 1.8 8.1 29.2 2.2 7.8 29.2 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 FAM199X PF15814.5 CDI86750.1 - 3.3 6.7 23.4 4.1 6.4 23.4 1.2 1 0 0 1 1 1 0 Protein family FAM199X Prenyltransf PF01255.19 CDI86751.1 - 1.4e-08 34.6 4.9 1.4e-08 34.6 4.9 1.8 2 1 0 2 2 2 1 Putative undecaprenyl diphosphate synthase TERB2 PF15101.6 CDI86751.1 - 0.00025 21.2 15.2 0.00025 21.2 15.2 2.2 2 0 0 2 2 2 1 Telomere-associated protein TERB2 CNDH2_C PF16858.5 CDI86751.1 - 0.0087 16.0 7.5 0.0087 16.0 7.5 2.1 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term Sporozoite_P67 PF05642.11 CDI86751.1 - 0.039 12.1 18.7 0.057 11.5 18.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Coilin_N PF15862.5 CDI86751.1 - 0.089 12.6 28.0 0.032 14.0 5.9 2.3 2 0 0 2 2 2 0 Coilin N-terminus DUF2052 PF09747.9 CDI86751.1 - 0.19 11.9 32.0 0.015 15.5 11.5 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) AAA_23 PF13476.6 CDI86751.1 - 0.21 12.1 26.5 0.24 11.9 2.8 2.1 2 0 0 2 2 2 0 AAA domain MecA PF05389.12 CDI86751.1 - 0.43 10.2 17.6 0.74 9.4 6.7 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) MMR1 PF08505.10 CDI86751.1 - 0.75 10.0 32.6 0.057 13.7 13.8 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein DUF719 PF05334.13 CDI86751.1 - 0.8 9.9 22.9 2.3 8.4 8.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF719) RskA PF10099.9 CDI86751.1 - 1.8 8.8 56.0 23 5.2 33.3 4.0 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF4342 PF14242.6 CDI86751.1 - 2.7 8.1 0.0 2.7 8.1 0.0 2.9 3 0 0 3 3 1 0 Domain of unknown function (DUF4342) DUF5523 PF17661.1 CDI86751.1 - 2.9 7.5 32.7 0.025 14.3 9.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Thg1C PF14413.6 CDI86751.1 - 3 8.0 22.2 0.25 11.5 5.7 2.5 2 0 0 2 2 2 0 Thg1 C terminal domain DUF3807 PF12720.7 CDI86751.1 - 3 8.1 40.5 0.26 11.5 15.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) SpoIIP PF07454.11 CDI86751.1 - 3.4 7.1 29.5 0.26 10.7 10.2 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) NEMP PF10225.9 CDI86751.1 - 3.4 7.2 13.9 0.24 11.1 4.2 2.1 2 0 0 2 2 2 0 NEMP family eIF-3_zeta PF05091.12 CDI86751.1 - 4.2 6.2 37.1 0.5 9.3 14.3 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4813 PF16072.5 CDI86751.1 - 5.1 6.7 25.9 8.3 6.0 25.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) DUF1980 PF09323.10 CDI86751.1 - 5.5 6.9 18.0 7.6 6.4 1.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) FAM176 PF14851.6 CDI86751.1 - 6 6.5 23.2 0.27 10.9 5.8 2.3 2 0 0 2 2 2 0 FAM176 family NPR3 PF03666.13 CDI86751.1 - 7.3 5.3 26.2 0.1 11.4 6.0 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 CDI86751.1 - 9.4 4.4 23.4 3.7 5.7 4.3 2.0 2 0 0 2 2 2 0 CDC45-like protein Peptidase_S49_N PF08496.10 CDI86751.1 - 9.6 6.3 23.5 5.6 7.0 10.0 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal CPSF100_C PF13299.6 CDI86751.1 - 9.8 6.3 31.0 3.5 7.8 15.1 2.5 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal CD20 PF04103.15 CDI86752.1 - 0.028 14.5 3.2 0.32 11.1 0.1 2.3 2 0 0 2 2 2 0 CD20-like family DUF2232 PF09991.9 CDI86752.1 - 1.4 8.1 8.7 0.25 10.5 0.4 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) SR-25 PF10500.9 CDI86752.1 - 1.6 8.3 33.9 0.47 10.0 0.4 2.4 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein DcuA_DcuB PF03605.14 CDI86752.1 - 2.1 7.2 11.7 0.22 10.4 1.3 2.1 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter DUF3807 PF12720.7 CDI86752.1 - 2.4 8.4 47.4 3.5 7.9 27.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) FAM60A PF15396.6 CDI86752.1 - 4.3 7.3 29.0 0.78 9.7 3.0 2.2 2 0 0 2 2 2 0 Protein Family FAM60A DUF3371 PF11851.8 CDI86752.1 - 4.7 8.3 30.1 9.7 7.3 13.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) MMR1 PF08505.10 CDI86752.1 - 5.2 7.3 41.5 3.2 8.0 20.7 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein NEMP PF10225.9 CDI86752.1 - 6.8 6.3 12.8 9.4 5.8 0.7 2.1 2 0 0 2 2 2 0 NEMP family SLATT_6 PF18169.1 CDI86752.1 - 9.8 5.7 10.2 0.27 10.8 0.4 2.1 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 DUF5349 PF17298.2 CDI86752.1 - 9.8 5.8 30.4 3.1 7.5 12.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5349) GT87 PF09594.10 CDI86753.1 - 0.053 13.2 10.8 0.069 12.9 10.8 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 87 Ferrochelatase PF00762.19 CDI86754.1 - 9.6e-31 107.0 1.2 5.6e-14 51.9 0.2 3.1 2 1 1 3 3 3 3 Ferrochelatase RskA PF10099.9 CDI86754.1 - 1.3 9.3 26.2 1.8 8.8 2.6 2.8 3 0 0 3 3 3 0 Anti-sigma-K factor rskA RIB43A PF05914.12 CDI86756.1 - 0.00057 18.7 20.1 0.00058 18.7 20.1 1.0 1 0 0 1 1 1 1 RIB43A Tau95_N PF17682.1 CDI86756.1 - 0.002 18.3 2.6 0.0021 18.2 2.6 1.0 1 0 0 1 1 1 1 Tau95 Triple barrel domain RED_N PF07808.13 CDI86756.1 - 0.003 17.2 7.7 0.0032 17.1 7.7 1.0 1 0 0 1 1 1 1 RED-like protein N-terminal region TMEM51 PF15345.6 CDI86756.1 - 0.031 14.1 8.3 0.035 13.9 8.3 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 PIP5K PF01504.18 CDI86756.1 - 0.06 12.6 3.0 0.064 12.5 3.0 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Spt20 PF12090.8 CDI86756.1 - 0.093 12.3 23.6 0.098 12.3 23.6 1.0 1 0 0 1 1 1 0 Spt20 family Peptidase_S49_N PF08496.10 CDI86756.1 - 0.097 12.7 6.8 0.11 12.5 6.8 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal TOH_N PF12549.8 CDI86756.1 - 0.098 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine hydroxylase N terminal AIF_C PF14721.6 CDI86756.1 - 0.11 12.9 2.9 0.11 12.9 2.9 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4834 PF16118.5 CDI86756.1 - 0.15 13.0 9.4 0.16 12.9 9.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) RBM39linker PF15519.6 CDI86756.1 - 0.15 13.2 6.2 0.16 13.0 6.2 1.1 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein Suf PF05843.14 CDI86756.1 - 0.16 11.9 8.8 0.14 12.1 8.8 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2722 PF10846.8 CDI86756.1 - 0.18 10.7 20.6 0.19 10.6 20.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF3464 PF11947.8 CDI86756.1 - 0.23 11.2 6.1 0.23 11.2 6.1 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 BRF1 PF07741.13 CDI86756.1 - 0.36 11.2 7.8 0.38 11.1 7.8 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain TERB2 PF15101.6 CDI86756.1 - 0.36 10.8 9.7 0.34 10.9 9.7 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 EIIBC-GUT_N PF03612.14 CDI86756.1 - 0.4 10.4 4.5 0.41 10.4 4.5 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Med15 PF09606.10 CDI86756.1 - 0.4 9.3 19.0 0.39 9.3 19.0 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI86756.1 - 0.46 10.4 19.9 0.47 10.4 19.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Connexin PF00029.19 CDI86756.1 - 0.68 9.6 3.7 0.67 9.7 3.7 1.0 1 0 0 1 1 1 0 Connexin Activator_LAG-3 PF11498.8 CDI86756.1 - 0.72 8.8 29.0 0.68 8.8 29.0 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 UPF0560 PF10577.9 CDI86756.1 - 0.74 8.2 11.3 0.73 8.3 11.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Presenilin PF01080.17 CDI86756.1 - 1.1 8.0 7.3 1 8.0 7.3 1.0 1 0 0 1 1 1 0 Presenilin MscS_TM PF12794.7 CDI86756.1 - 1.1 8.0 7.0 1.2 8.0 7.0 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 CLN3 PF02487.17 CDI86756.1 - 1.4 7.9 3.3 1.3 7.9 3.3 1.0 1 0 0 1 1 1 0 CLN3 protein MctB PF11382.8 CDI86756.1 - 1.8 8.2 10.0 2.1 8.0 10.0 1.0 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB DUF1682 PF07946.14 CDI86756.1 - 2.4 7.3 11.1 2.6 7.2 11.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) MITF_TFEB_C_3_N PF15951.5 CDI86756.1 - 2.9 8.5 22.0 3.8 8.1 22.0 1.2 1 0 0 1 1 1 0 MITF/TFEB/TFEC/TFE3 N-terminus DivIC PF04977.15 CDI86756.1 - 3.1 7.6 16.7 3.9 7.3 16.7 1.2 1 0 0 1 1 1 0 Septum formation initiator DUF4407 PF14362.6 CDI86756.1 - 3.4 6.9 11.0 3.3 7.0 11.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) eIF-3_zeta PF05091.12 CDI86756.1 - 3.4 6.5 12.9 3.4 6.5 12.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rpp20 PF12328.8 CDI86756.1 - 8.6 6.3 11.0 10 6.1 11.0 1.1 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P EphA2_TM PF14575.6 CDI86756.1 - 9.7 7.2 6.6 13 6.8 6.6 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RskA PF10099.9 CDI86757.1 - 2.1e-08 34.6 12.3 3.1e-05 24.3 0.1 8.1 3 3 4 7 7 7 3 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI86757.1 - 7.2e-06 25.8 107.1 0.0008 19.1 33.5 5.3 5 0 0 5 5 5 4 Nuclear RNA-splicing-associated protein Auxin_canalis PF05703.11 CDI86758.1 - 0.0015 18.5 24.2 0.0018 18.3 24.2 1.0 1 0 0 1 1 1 1 Auxin canalisation DUF4207 PF13904.6 CDI86758.1 - 0.0057 16.4 18.7 0.0077 16.0 18.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) DUF2500 PF10694.9 CDI86758.1 - 0.95 10.0 4.0 2.2 8.8 4.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2500) DUF737 PF05300.11 CDI86758.1 - 1 9.7 10.5 1.6 9.1 10.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF737) TFIIA PF03153.13 CDI86758.1 - 3.2 7.7 22.3 4.5 7.2 22.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Miga PF10265.9 CDI86758.1 - 9.5 5.1 20.6 12 4.8 20.6 1.2 1 0 0 1 1 1 0 Mitoguardin SR-25 PF10500.9 CDI86759.1 - 0.00023 20.8 2.5 0.00023 20.8 2.5 19.4 11 3 6 20 20 20 4 Nuclear RNA-splicing-associated protein DUF4757 PF15949.5 CDI86759.1 - 1.9 8.9 0.0 1.9 8.9 0.0 19.1 11 5 5 17 17 17 0 Domain of unknown function (DUF4757) WD40 PF00400.32 CDI86762.1 - 1.8e-11 44.4 1.8 0.0002 22.1 0.2 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI86762.1 - 5e-07 29.9 0.1 0.00098 19.4 0.0 1.8 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain AP2 PF00847.20 CDI86764.1 - 5.2e-09 36.2 0.1 1.4e-08 34.8 0.1 1.7 1 0 0 1 1 1 1 AP2 domain TFIIA PF03153.13 CDI86764.1 - 0.1 12.6 12.1 0.13 12.2 12.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit C2 PF00168.30 CDI86765.1 - 7.7e-35 119.3 0.1 2.3e-07 31.0 0.0 6.4 6 0 0 6 6 6 6 C2 domain Ferlin_C PF16165.5 CDI86765.1 - 0.013 15.5 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Ferlin C-terminus Pyr_redox_2 PF07992.14 CDI86766.1 - 4.8e-64 216.4 2.0 4.8e-64 216.4 2.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDI86766.1 - 1.6e-35 121.7 0.0 3.7e-35 120.5 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDI86766.1 - 7.5e-21 74.5 8.4 2.4e-18 66.5 0.3 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDI86766.1 - 1.6e-10 41.0 0.4 1.6e-10 41.0 0.4 2.6 4 0 0 4 4 3 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CDI86766.1 - 5.5e-08 32.4 0.8 0.00047 19.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDI86766.1 - 1.8e-06 27.3 2.6 1.8e-06 27.3 2.6 2.5 2 1 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CDI86766.1 - 2.1e-06 27.8 3.8 7.6e-05 22.9 0.4 3.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CDI86766.1 - 1.9e-05 24.0 0.1 0.021 14.0 0.1 2.7 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 CDI86766.1 - 9.5e-05 21.6 8.2 0.0033 16.6 3.0 3.1 2 1 1 3 3 3 2 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CDI86766.1 - 0.0003 20.2 1.7 0.045 13.0 0.1 2.6 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CDI86766.1 - 0.00043 19.6 0.1 0.0012 18.2 0.1 1.6 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 CDI86766.1 - 0.00074 18.9 8.3 0.22 10.7 0.8 3.4 2 1 1 3 3 3 2 FAD binding domain HI0933_like PF03486.14 CDI86766.1 - 0.0068 15.1 1.0 0.0068 15.1 1.0 4.3 4 1 1 5 5 5 1 HI0933-like protein 3HCDH_N PF02737.18 CDI86766.1 - 0.057 13.3 0.1 0.057 13.3 0.1 2.7 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ERM PF00769.19 CDI86766.1 - 0.16 11.8 14.0 0.27 11.0 14.0 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Exonuc_VII_L PF02601.15 CDI86766.1 - 0.34 10.5 4.7 0.78 9.2 4.7 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit ADIP PF11559.8 CDI86766.1 - 5.8 7.0 13.5 11 6.1 13.5 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Peptidase_S9 PF00326.21 CDI86767.1 - 0.00037 20.0 0.0 0.09 12.2 0.1 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CDI86767.1 - 0.019 14.8 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 CDI86767.1 - 0.075 12.7 0.0 10 5.6 0.0 2.1 1 1 0 2 2 2 0 alpha/beta hydrolase fold PhoPQ_related PF10142.9 CDI86767.1 - 0.18 10.4 0.1 0.45 9.1 0.0 1.6 2 0 0 2 2 2 0 PhoPQ-activated pathogenicity-related protein Say1_Mug180 PF10340.9 CDI86767.1 - 0.18 10.6 0.0 0.25 10.1 0.0 1.1 1 0 0 1 1 1 0 Steryl acetyl hydrolase Peptidase_S9_N PF02897.15 CDI86768.1 - 9.9e-105 350.7 0.0 1.2e-104 350.4 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 CDI86768.1 - 5.6e-46 156.7 0.0 1.6e-45 155.2 0.0 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 CDI86768.1 - 0.024 13.3 0.0 0.039 12.6 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Biotin_lipoyl PF00364.22 CDI86771.1 - 5e-16 58.3 0.2 7.6e-16 57.7 0.2 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CDI86771.1 - 0.00021 21.1 0.1 0.0006 19.6 0.1 1.8 1 1 0 1 1 1 1 Biotin-lipoyl like DUF4564 PF15169.6 CDI86771.1 - 0.078 12.7 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4564) PPL5 PF18168.1 CDI86773.1 - 0.48 9.7 20.7 0.49 9.6 20.7 1.0 1 0 0 1 1 1 0 Prim-pol family 5 RSB_motif PF16294.5 CDI86773.1 - 0.65 10.3 21.4 0.75 10.1 21.4 1.1 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif Peptidase_S49_N PF08496.10 CDI86773.1 - 1.3 9.0 26.2 1.7 8.7 26.2 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal NARP1 PF12569.8 CDI86773.1 - 2.7 6.8 26.6 2.7 6.8 26.6 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 V_ATPase_I PF01496.19 CDI86773.1 - 5.1 4.9 27.7 5.4 4.8 27.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NST1 PF13945.6 CDI86773.1 - 5.2 7.1 36.2 6 6.9 36.2 1.0 1 0 0 1 1 1 0 Salt tolerance down-regulator RRM_1 PF00076.22 CDI86774.1 - 1.5e-09 37.5 0.0 2.4e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDI86774.1 - 0.0016 18.4 0.0 0.0027 17.7 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RA PF00788.23 CDI86774.1 - 0.098 13.3 0.0 0.17 12.6 0.0 1.4 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain DnaJ PF00226.31 CDI86776.1 - 7.3e-24 83.7 1.5 1.3e-23 82.9 1.5 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 CDI86776.1 - 1.3e-10 41.6 0.0 2.4e-07 31.0 0.0 2.3 1 1 1 2 2 2 2 DnaJ C terminal domain Exonuc_VII_L PF02601.15 CDI86778.1 - 0.00015 21.5 1.4 0.00016 21.3 1.4 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit DUF853 PF05872.12 CDI86778.1 - 0.27 9.8 11.0 0.4 9.2 11.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Hid1 PF12722.7 CDI86778.1 - 2.1 6.3 13.8 2.7 6.0 13.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CDI86778.1 - 2.8 4.9 13.3 3.3 4.7 13.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SARAF PF06682.12 CDI86778.1 - 4.5 6.8 26.3 1.3 8.7 21.9 1.9 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Neur_chan_memb PF02932.16 CDI86778.1 - 5 7.1 11.9 8.3 6.4 11.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4637 PF15470.6 CDI86779.1 - 0.95 9.2 9.8 1 9.1 9.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Dfp1_Him1_M PF08630.10 CDI86779.1 - 1.4 9.1 13.3 1.8 8.8 13.3 1.1 1 0 0 1 1 1 0 Dfp1/Him1, central region DUF3306 PF11748.8 CDI86779.1 - 1.5 9.7 16.4 1.7 9.5 16.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) DUF4366 PF14283.6 CDI86779.1 - 2.3 8.3 11.3 2.6 8.1 11.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) CobT PF06213.12 CDI86779.1 - 2.6 7.4 24.0 2.7 7.3 24.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Rtf2 PF04641.12 CDI86779.1 - 2.9 7.2 17.9 3.3 7.0 17.9 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger SelP_N PF04592.14 CDI86779.1 - 3.2 7.1 21.1 3.5 7.0 21.1 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF1764 PF08576.10 CDI86779.1 - 3.3 8.7 15.4 4.8 8.1 15.4 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) MDM10 PF12519.8 CDI86779.1 - 3.3 6.5 20.3 3.5 6.4 20.3 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF913 PF06025.12 CDI86779.1 - 3.7 6.4 14.9 3.8 6.4 14.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 CDI86779.1 - 4.7 5.9 23.5 4.8 5.8 23.5 1.0 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 CDI86779.1 - 5.4 5.7 17.4 6.4 5.4 17.4 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Sec62 PF03839.16 CDI86779.1 - 5.7 6.4 18.1 5.8 6.3 18.1 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 FAM176 PF14851.6 CDI86779.1 - 5.8 6.6 12.4 7.1 6.3 12.4 1.2 1 0 0 1 1 1 0 FAM176 family CPSF100_C PF13299.6 CDI86779.1 - 6.1 7.0 15.7 7 6.8 15.7 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal AIF_C PF14721.6 CDI86779.1 - 7.1 7.0 15.4 10 6.5 15.4 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term PIP5K PF01504.18 CDI86779.1 - 7.2 5.7 19.3 8.4 5.5 19.3 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase CCDC53 PF10152.9 CDI86779.1 - 7.6 6.9 20.8 8.7 6.8 20.8 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Connexin PF00029.19 CDI86779.1 - 7.6 6.2 19.3 7.5 6.2 19.3 1.0 1 0 0 1 1 1 0 Connexin Kei1 PF08552.11 CDI86779.1 - 8.2 6.3 16.9 9.1 6.1 16.9 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 RR_TM4-6 PF06459.12 CDI86779.1 - 9 6.0 21.6 10 5.9 21.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2370 PF10176.9 CDI86779.1 - 9.6 5.8 13.3 10 5.7 13.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) NPR3 PF03666.13 CDI86779.1 - 9.7 4.9 19.7 11 4.6 19.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Spt20 PF12090.8 CDI86780.1 - 0.025 14.2 25.9 0.051 13.2 13.1 2.1 2 0 0 2 2 2 0 Spt20 family DUF4452 PF14618.6 CDI86780.1 - 0.084 12.7 6.4 1.1 9.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4452) CDK2AP PF09806.9 CDI86780.1 - 0.11 12.5 17.9 0.16 12.0 17.9 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DUF2722 PF10846.8 CDI86780.1 - 0.32 9.9 17.6 0.08 11.9 7.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF572 PF04502.13 CDI86780.1 - 0.41 10.2 9.2 0.53 9.9 9.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4778 PF16008.5 CDI86780.1 - 0.45 10.5 10.4 0.55 10.3 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) MPM1 PF17234.2 CDI86780.1 - 0.6 10.4 8.8 1.2 9.4 4.3 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 STAC2_u1 PF16664.5 CDI86780.1 - 3.1 8.3 10.4 17 5.9 5.1 2.2 2 0 0 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 PAT1 PF09770.9 CDI86780.1 - 8 4.6 21.5 8.9 4.4 21.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Caldesmon PF02029.15 CDI86782.1 - 0.28 9.9 20.8 0.49 9.1 20.8 1.3 1 0 0 1 1 1 0 Caldesmon MAP7 PF05672.11 CDI86783.1 - 0.2 11.3 57.6 0.28 10.8 57.6 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family PAT1 PF09770.9 CDI86783.1 - 0.8 7.9 60.8 0.93 7.7 60.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI86783.1 - 2.2 5.3 41.2 2.6 5.0 41.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CDC45 PF02724.14 CDI86783.1 - 3 6.0 40.8 3.9 5.7 40.8 1.1 1 0 0 1 1 1 0 CDC45-like protein RIFIN PF02009.16 CDI86783.1 - 8.6 6.1 21.3 12 5.7 21.3 1.2 1 0 0 1 1 1 0 Rifin LETM1 PF07766.13 CDI86784.1 - 0.0053 16.1 0.2 0.0053 16.1 0.2 3.2 2 1 1 3 3 3 1 LETM1-like protein DUF4576 PF15144.6 CDI86784.1 - 0.04 13.8 0.0 0.099 12.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) Pox_A12 PF04651.13 CDI86785.1 - 0.038 14.0 2.7 0.059 13.4 2.7 1.2 1 0 0 1 1 1 0 Poxvirus A12 protein SR-25 PF10500.9 CDI86785.1 - 0.7 9.5 23.7 0.54 9.8 18.8 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CobT PF06213.12 CDI86786.1 - 0.027 13.9 23.6 0.031 13.7 23.6 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MRNIP PF15749.5 CDI86786.1 - 0.045 14.5 6.2 0.056 14.2 6.2 1.2 1 0 0 1 1 1 0 MRN-interacting protein RNA_pol_Rpc4 PF05132.14 CDI86786.1 - 0.092 13.2 6.3 0.098 13.1 6.3 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 BUD22 PF09073.10 CDI86786.1 - 0.15 11.3 19.6 0.17 11.2 19.6 1.0 1 0 0 1 1 1 0 BUD22 DUF2428 PF10350.9 CDI86786.1 - 0.21 10.8 2.5 0.23 10.7 2.5 1.1 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) DNA_pol_phi PF04931.13 CDI86786.1 - 0.23 9.5 30.1 0.26 9.3 30.1 1.0 1 0 0 1 1 1 0 DNA polymerase phi FYDLN_acid PF09538.10 CDI86786.1 - 0.26 12.0 15.3 0.35 11.6 15.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) PTPRCAP PF15713.5 CDI86786.1 - 0.31 11.3 25.3 0.38 11.0 25.3 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RPN2_C PF18004.1 CDI86786.1 - 0.35 10.8 15.6 0.43 10.5 15.6 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain TRAP_alpha PF03896.16 CDI86786.1 - 0.37 9.9 11.5 0.43 9.7 11.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Mpp10 PF04006.12 CDI86786.1 - 0.45 8.9 24.9 0.5 8.7 24.9 1.0 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 CDI86786.1 - 0.47 8.6 25.6 0.49 8.6 25.6 1.0 1 0 0 1 1 1 0 Nop14-like family Connexin PF00029.19 CDI86786.1 - 0.51 10.1 6.8 0.52 10.0 6.8 1.1 1 0 0 1 1 1 0 Connexin CPSF100_C PF13299.6 CDI86786.1 - 0.71 10.0 9.4 0.9 9.7 9.4 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 CDI86786.1 - 1 9.1 16.5 1.2 8.9 16.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNA_polI_A34 PF08208.11 CDI86786.1 - 1.1 9.3 17.2 1.2 9.2 17.2 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF913 PF06025.12 CDI86786.1 - 1.3 7.9 6.6 1.4 7.9 6.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SpoIIP PF07454.11 CDI86786.1 - 1.4 8.3 11.3 1.6 8.1 11.3 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DDHD PF02862.17 CDI86786.1 - 1.7 8.8 3.0 1.8 8.7 3.0 1.1 1 0 0 1 1 1 0 DDHD domain Coilin_N PF15862.5 CDI86786.1 - 2.3 8.0 9.1 2.7 7.8 9.1 1.1 1 0 0 1 1 1 0 Coilin N-terminus CDC45 PF02724.14 CDI86786.1 - 2.8 6.1 21.0 3.2 5.9 21.0 1.0 1 0 0 1 1 1 0 CDC45-like protein HSP90 PF00183.18 CDI86786.1 - 3 6.7 19.3 3.3 6.5 19.3 1.0 1 0 0 1 1 1 0 Hsp90 protein Serinc PF03348.15 CDI86786.1 - 3.3 6.6 3.9 3.5 6.4 3.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2457 PF10446.9 CDI86786.1 - 3.9 6.5 29.4 4.7 6.3 29.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Astro_capsid_p PF12226.8 CDI86786.1 - 4.5 6.3 15.4 5 6.2 15.4 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein SpoIIIAH PF12685.7 CDI86786.1 - 5.1 6.9 13.0 5.5 6.8 13.0 1.0 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF4820 PF16091.5 CDI86786.1 - 5.7 6.2 10.4 7.1 5.9 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) V_ATPase_I PF01496.19 CDI86786.1 - 7.3 4.4 10.1 8 4.2 10.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 CDI86786.1 - 8 5.1 10.9 9.5 4.9 10.9 1.0 1 0 0 1 1 1 0 Presenilin Plasmodium_Vir PF05795.11 CDI86786.1 - 8.7 5.7 10.6 9.7 5.5 10.6 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein NARP1 PF12569.8 CDI86786.1 - 8.9 5.1 9.4 9.8 4.9 9.4 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Spt20 PF12090.8 CDI86788.1 - 0.00021 21.0 45.1 0.00059 19.5 13.6 3.0 3 0 0 3 3 3 2 Spt20 family WASH-7_C PF14746.6 CDI86788.1 - 0.019 14.6 3.1 0.019 14.6 3.1 2.4 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal RAB3GAP2_N PF14655.6 CDI86788.1 - 0.1 11.9 9.9 0.1 11.8 0.7 2.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Spore_YhcN_YlaJ PF09580.10 CDI86788.1 - 0.16 12.0 7.9 0.16 12.1 0.1 2.3 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF4834 PF16118.5 CDI86789.1 - 0.008 17.1 3.2 0.011 16.6 3.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Spem1 PF15670.5 CDI86789.1 - 0.024 14.2 1.6 0.038 13.6 1.6 1.4 1 0 0 1 1 1 0 Spermatid maturation protein 1 DUF2347 PF09804.9 CDI86789.1 - 0.082 12.5 1.5 0.12 11.9 1.5 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) FTO_NTD PF12933.7 CDI86789.1 - 0.14 11.4 7.2 0.23 10.7 7.2 1.3 1 0 0 1 1 1 0 FTO catalytic domain SID-1_RNA_chan PF13965.6 CDI86789.1 - 0.14 10.5 0.2 0.12 10.8 0.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI86789.1 - 0.17 9.7 3.3 0.14 10.0 3.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2407_C PF13373.6 CDI86789.1 - 0.19 11.9 4.8 0.29 11.3 4.8 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain TFIIA PF03153.13 CDI86789.1 - 0.51 10.3 30.4 0.64 10.0 30.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI86789.1 - 0.93 9.1 23.5 0.18 11.4 20.4 1.4 2 0 0 2 2 2 0 Spt20 family Med15 PF09606.10 CDI86789.1 - 1 8.0 24.6 1.1 7.8 24.6 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Hid1 PF12722.7 CDI86789.1 - 2 6.5 4.9 1.5 6.8 4.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RAB3GAP2_N PF14655.6 CDI86789.1 - 5.5 6.1 10.0 5.1 6.3 9.1 1.2 1 1 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Sporozoite_P67 PF05642.11 CDI86789.1 - 9.2 4.2 13.7 0.96 7.5 9.1 1.5 1 1 0 2 2 2 0 Sporozoite P67 surface antigen RskA PF10099.9 CDI86790.1 - 0.001 19.4 11.1 0.001 19.4 11.1 3.1 1 1 2 3 3 3 2 Anti-sigma-K factor rskA DUF572 PF04502.13 CDI86790.1 - 0.018 14.7 24.9 0.052 13.2 17.8 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF572) TMEM51 PF15345.6 CDI86790.1 - 0.052 13.4 0.5 0.052 13.4 0.5 2.7 2 1 0 2 2 2 0 Transmembrane protein 51 Spt20 PF12090.8 CDI86790.1 - 0.11 12.1 57.4 0.022 14.4 15.6 3.1 3 0 0 3 3 3 0 Spt20 family OmpH PF03938.14 CDI86790.1 - 0.21 11.9 41.5 0.12 12.7 16.1 3.0 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) Vfa1 PF08432.10 CDI86790.1 - 5 7.4 26.2 1.8 8.9 6.1 3.1 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 Tic110 PF16940.5 CDI86791.1 - 8.6 4.7 17.3 8.5 4.7 17.3 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter Ribosomal_60s PF00428.19 CDI86792.1 - 1.2 9.7 45.8 0.71 10.5 7.7 4.0 4 0 0 4 4 4 0 60s Acidic ribosomal protein SARAF PF06682.12 CDI86794.1 - 3.4e-05 23.7 12.4 3.4e-05 23.7 12.4 2.4 2 1 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis Peptidase_S15 PF02129.18 CDI86794.1 - 0.001 18.8 10.6 0.001 18.8 10.6 2.9 1 1 1 3 3 3 1 X-Pro dipeptidyl-peptidase (S15 family) Lin-8 PF03353.15 CDI86794.1 - 0.038 13.6 19.3 0.094 12.3 5.3 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Activator_LAG-3 PF11498.8 CDI86794.1 - 2.1 7.3 43.5 0.028 13.4 27.9 2.7 3 0 0 3 3 3 0 Transcriptional activator LAG-3 CDC45 PF02724.14 CDI86794.1 - 2.5 6.3 16.8 0.68 8.2 3.7 2.2 2 0 0 2 2 2 0 CDC45-like protein Neur_chan_memb PF02932.16 CDI86794.1 - 4 7.4 14.8 1.6 8.7 3.5 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Connexin PF00029.19 CDI86794.1 - 4.7 6.9 7.4 0.8 9.4 1.7 2.0 2 0 0 2 2 2 0 Connexin RPA43_OB PF17875.1 CDI86794.1 - 5.7 7.6 9.5 0.62 10.7 4.0 2.1 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Eapp_C PF10238.9 CDI86794.1 - 8.6 6.4 11.9 0.32 11.1 2.9 2.4 2 0 0 2 2 2 0 E2F-associated phosphoprotein MAP65_ASE1 PF03999.12 CDI86796.1 - 2.7 6.6 30.3 3.6 6.2 30.3 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DcuA_DcuB PF03605.14 CDI86796.1 - 5.6 5.7 14.7 3 6.6 1.3 2.2 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter FHIPEP PF00771.20 CDI86797.1 - 0.006 15.1 8.2 0.0061 15.1 8.2 1.0 1 0 0 1 1 1 1 FHIPEP family RskA PF10099.9 CDI86797.1 - 0.014 15.7 23.4 0.015 15.6 23.4 1.0 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI86797.1 - 0.08 12.5 35.0 0.083 12.5 35.0 1.1 1 0 0 1 1 1 0 Spt20 family CD20 PF04103.15 CDI86797.1 - 0.13 12.3 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 CD20-like family DUF3408 PF11888.8 CDI86797.1 - 0.18 11.9 14.6 0.19 11.8 14.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) SID-1_RNA_chan PF13965.6 CDI86797.1 - 0.2 10.0 4.3 0.19 10.1 4.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF3381 PF11861.8 CDI86797.1 - 0.23 11.2 18.5 0.24 11.2 18.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) MCU PF04678.13 CDI86797.1 - 0.26 11.4 12.2 0.27 11.3 12.2 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter AIF_C PF14721.6 CDI86797.1 - 0.29 11.5 12.5 0.35 11.2 12.5 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term EOS1 PF12326.8 CDI86797.1 - 0.51 10.3 8.4 0.53 10.2 8.4 1.1 1 0 0 1 1 1 0 N-glycosylation protein DUF4820 PF16091.5 CDI86797.1 - 0.54 9.6 11.4 0.68 9.3 11.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF2992 PF11208.8 CDI86797.1 - 0.59 10.4 23.9 0.75 10.0 23.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) DUF2232 PF09991.9 CDI86797.1 - 0.63 9.2 2.8 0.69 9.0 2.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Med15 PF09606.10 CDI86797.1 - 0.64 8.6 26.7 0.63 8.7 26.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TERB2 PF15101.6 CDI86797.1 - 0.68 9.9 18.0 0.67 10.0 18.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Med19 PF10278.9 CDI86797.1 - 0.76 9.7 14.7 0.87 9.5 14.7 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF4834 PF16118.5 CDI86797.1 - 0.83 10.7 17.0 0.92 10.5 17.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) eIF-3_zeta PF05091.12 CDI86797.1 - 0.83 8.6 19.0 0.84 8.5 19.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Coilin_N PF15862.5 CDI86797.1 - 0.89 9.4 21.3 1 9.2 21.3 1.2 1 0 0 1 1 1 0 Coilin N-terminus DUF3682 PF12446.8 CDI86797.1 - 0.92 10.0 24.1 1.2 9.6 24.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Connexin PF00029.19 CDI86797.1 - 0.93 9.2 12.9 1 9.1 12.9 1.0 1 0 0 1 1 1 0 Connexin R_equi_Vir PF05526.11 CDI86797.1 - 1.2 8.9 12.0 1.2 8.9 12.0 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein TFIIA PF03153.13 CDI86797.1 - 1.3 8.9 35.8 1.3 8.9 35.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ureide_permease PF07168.11 CDI86797.1 - 1.4 7.6 9.8 1.5 7.5 9.8 1.1 1 0 0 1 1 1 0 Ureide permease DUF4228 PF14009.6 CDI86797.1 - 1.4 9.3 12.2 1.6 9.1 12.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) G0-G1_switch_2 PF15103.6 CDI86797.1 - 1.5 9.3 11.0 2 8.9 11.0 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 SpoIIP PF07454.11 CDI86797.1 - 1.6 8.2 18.3 1.8 8.0 18.3 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) NEMP PF10225.9 CDI86797.1 - 1.6 8.3 4.6 1.8 8.2 4.6 1.0 1 0 0 1 1 1 0 NEMP family TRAP_alpha PF03896.16 CDI86797.1 - 1.6 7.9 9.6 1.7 7.8 9.6 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Tim54 PF11711.8 CDI86797.1 - 1.6 7.4 17.5 1.6 7.4 17.5 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PMSI1 PF15322.6 CDI86797.1 - 1.7 8.0 12.8 1.9 7.9 12.8 1.1 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Serinc PF03348.15 CDI86797.1 - 1.8 7.4 11.3 1.8 7.4 11.3 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) 2HCT PF03390.15 CDI86797.1 - 1.8 7.1 5.3 2 6.9 5.3 1.0 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family CSG2 PF16965.5 CDI86797.1 - 1.9 7.4 8.6 1.8 7.4 8.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator UPF0239 PF06783.11 CDI86797.1 - 2 8.7 12.9 2.6 8.3 12.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) IHABP4_N PF16174.5 CDI86797.1 - 2.2 8.8 24.5 3.1 8.4 24.5 1.3 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal SLC12 PF03522.15 CDI86797.1 - 2.4 7.1 14.9 2.3 7.1 14.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 tRNA_lig_CPD PF08302.11 CDI86797.1 - 2.5 7.5 16.8 3.2 7.1 16.8 1.1 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain CPSF100_C PF13299.6 CDI86797.1 - 2.6 8.2 15.8 3 8.0 15.8 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FAM60A PF15396.6 CDI86797.1 - 2.6 8.0 12.6 2.8 7.9 12.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A BAF1_ABF1 PF04684.13 CDI86797.1 - 2.7 7.0 19.2 3.1 6.8 19.2 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4011 PF13195.6 CDI86797.1 - 3 7.8 9.0 3.2 7.6 9.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) Rxt3 PF08642.10 CDI86797.1 - 3.8 8.3 9.0 4.6 8.0 9.0 1.3 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Band_3_cyto PF07565.13 CDI86797.1 - 4.3 7.0 14.4 4.4 7.0 14.4 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DDHD PF02862.17 CDI86797.1 - 4.4 7.4 16.4 4.8 7.3 16.4 1.1 1 0 0 1 1 1 0 DDHD domain DUF1980 PF09323.10 CDI86797.1 - 4.6 7.1 13.2 5 7.0 13.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF2828 PF11443.8 CDI86797.1 - 4.9 5.1 16.4 4.7 5.2 16.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) FAM176 PF14851.6 CDI86797.1 - 5.1 6.8 10.0 5.8 6.6 10.0 1.1 1 0 0 1 1 1 0 FAM176 family Peptidase_S49_N PF08496.10 CDI86797.1 - 5.4 7.1 15.8 6.8 6.7 15.8 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal OATP PF03137.20 CDI86797.1 - 5.4 5.2 9.2 5.6 5.1 9.2 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family RPN2_C PF18004.1 CDI86797.1 - 5.9 6.8 23.5 6.2 6.7 23.5 1.0 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pex14_N PF04695.13 CDI86797.1 - 6.1 7.5 25.8 7.1 7.3 25.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Exonuc_VII_L PF02601.15 CDI86797.1 - 6.4 6.3 19.4 7.3 6.1 19.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Pal1 PF08316.11 CDI86797.1 - 6.6 7.5 13.1 7.7 7.3 13.1 1.0 1 0 0 1 1 1 0 Pal1 cell morphology protein UPF0560 PF10577.9 CDI86797.1 - 6.6 5.1 19.7 6.7 5.1 19.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 FPN1 PF06963.12 CDI86797.1 - 6.8 5.1 6.5 7 5.1 6.5 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) DUF3450 PF11932.8 CDI86797.1 - 7 5.9 27.4 8.7 5.6 27.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) ALMT PF11744.8 CDI86797.1 - 8 5.2 11.4 7.7 5.2 11.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Suf PF05843.14 CDI86797.1 - 8.6 6.3 20.8 9.5 6.1 20.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) O-antigen_lig PF13425.6 CDI86797.1 - 9.1 4.9 7.7 9.1 4.9 7.7 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Pannexin_like PF12534.8 CDI86797.1 - 9.7 5.2 13.4 9.9 5.1 13.4 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 PI3K_1B_p101 PF10486.9 CDI86798.1 - 4.6 4.9 33.3 5.6 4.6 33.3 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SID-1_RNA_chan PF13965.6 CDI86799.1 - 0.19 10.1 1.0 0.28 9.5 1.0 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 CDI86799.1 - 1.6 7.6 4.0 2.7 6.8 4.0 1.4 1 0 0 1 1 1 0 Ceramide synthase regulator eIF-3_zeta PF05091.12 CDI86799.1 - 2.6 6.9 15.9 3.8 6.4 15.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) V_ATPase_I PF01496.19 CDI86799.1 - 3.9 5.3 11.4 6.1 4.6 11.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_23 PF13476.6 CDI86799.1 - 6.4 7.2 14.6 9.6 6.6 14.6 1.3 1 0 0 1 1 1 0 AAA domain SAPS PF04499.15 CDI86801.1 - 5.2e-05 22.2 1.7 5.2e-05 22.2 1.7 1.0 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein DDHD PF02862.17 CDI86801.1 - 0.00081 19.6 10.7 0.00099 19.3 10.7 1.1 1 0 0 1 1 1 1 DDHD domain Neur_chan_memb PF02932.16 CDI86801.1 - 0.0014 18.7 4.4 0.0014 18.7 4.4 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Serinc PF03348.15 CDI86801.1 - 0.0075 15.2 10.0 0.0096 14.9 10.0 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) CobT PF06213.12 CDI86801.1 - 0.0089 15.4 22.6 0.016 14.6 22.6 1.4 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT SID-1_RNA_chan PF13965.6 CDI86801.1 - 0.015 13.7 7.0 0.02 13.4 7.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Presenilin PF01080.17 CDI86801.1 - 0.02 13.7 17.8 0.026 13.3 17.8 1.1 1 0 0 1 1 1 0 Presenilin DUF1980 PF09323.10 CDI86801.1 - 0.025 14.5 9.9 0.032 14.2 9.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) eIF-3_zeta PF05091.12 CDI86801.1 - 0.028 13.4 23.0 0.034 13.1 23.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Drf_FH1 PF06346.12 CDI86801.1 - 0.029 14.1 25.8 0.038 13.7 25.8 1.1 1 0 0 1 1 1 0 Formin Homology Region 1 CLN3 PF02487.17 CDI86801.1 - 0.031 13.3 13.9 0.041 12.9 13.9 1.1 1 0 0 1 1 1 0 CLN3 protein DUF913 PF06025.12 CDI86801.1 - 0.052 12.5 11.4 0.068 12.1 11.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TFIIA PF03153.13 CDI86801.1 - 0.083 12.9 54.8 0.11 12.5 54.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF853 PF05872.12 CDI86801.1 - 0.089 11.4 11.3 0.1 11.1 11.3 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Ctr PF04145.15 CDI86801.1 - 0.11 13.1 9.6 0.17 12.5 9.6 1.2 1 0 0 1 1 1 0 Ctr copper transporter family PAT1 PF09770.9 CDI86801.1 - 0.12 10.6 30.3 0.14 10.4 30.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CPSF100_C PF13299.6 CDI86801.1 - 0.12 12.5 13.9 0.21 11.8 13.9 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SpoIIP PF07454.11 CDI86801.1 - 0.15 11.5 19.4 0.19 11.1 19.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.8 CDI86801.1 - 0.2 10.4 15.5 0.26 10.0 15.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Hamartin PF04388.12 CDI86801.1 - 0.2 10.3 17.9 0.26 9.9 17.9 1.1 1 0 0 1 1 1 0 Hamartin protein RR_TM4-6 PF06459.12 CDI86801.1 - 0.22 11.3 16.3 0.28 11.0 16.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Connexin PF00029.19 CDI86801.1 - 0.22 11.2 14.4 0.28 10.9 14.4 1.1 1 0 0 1 1 1 0 Connexin EOS1 PF12326.8 CDI86801.1 - 0.22 11.4 11.8 0.31 11.0 11.8 1.2 1 0 0 1 1 1 0 N-glycosylation protein Peptidase_S49_N PF08496.10 CDI86801.1 - 0.24 11.4 15.8 0.37 10.8 15.8 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal AIF_C PF14721.6 CDI86801.1 - 0.34 11.3 13.0 0.58 10.5 13.0 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FAM60A PF15396.6 CDI86801.1 - 0.34 10.9 13.4 0.43 10.5 13.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A FAM76 PF16046.5 CDI86801.1 - 0.34 10.2 21.0 0.46 9.8 21.0 1.1 1 0 0 1 1 1 0 FAM76 protein FAP PF07174.11 CDI86801.1 - 0.38 10.2 40.1 0.48 9.8 40.1 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) RPA43_OB PF17875.1 CDI86801.1 - 0.41 11.3 11.6 0.64 10.7 11.6 1.3 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I STAC2_u1 PF16664.5 CDI86801.1 - 0.44 11.0 12.0 0.71 10.3 12.0 1.4 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Eapp_C PF10238.9 CDI86801.1 - 0.55 10.3 19.3 0.81 9.8 19.3 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein GNAT_acetyltr_2 PF13718.6 CDI86801.1 - 0.56 9.6 12.5 0.76 9.1 12.5 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 SLC12 PF03522.15 CDI86801.1 - 0.56 9.2 17.2 0.67 8.9 17.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CTU2 PF10288.9 CDI86801.1 - 0.59 10.4 15.3 0.91 9.8 15.3 1.3 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 FAM176 PF14851.6 CDI86801.1 - 0.62 9.7 11.3 0.92 9.2 11.3 1.2 1 0 0 1 1 1 0 FAM176 family OATP PF03137.20 CDI86801.1 - 0.64 8.2 8.4 0.86 7.8 8.4 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family BORG_CEP PF14957.6 CDI86801.1 - 0.66 11.1 9.0 0.99 10.6 9.0 1.4 1 0 0 1 1 1 0 Cdc42 effector V_ATPase_I PF01496.19 CDI86801.1 - 0.71 7.7 20.6 0.81 7.5 20.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ALMT PF11744.8 CDI86801.1 - 0.71 8.6 17.1 0.87 8.3 17.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PTPRCAP PF15713.5 CDI86801.1 - 0.73 10.1 17.6 1.1 9.5 17.6 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Rxt3 PF08642.10 CDI86801.1 - 0.78 10.5 8.7 1.4 9.7 8.7 1.5 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 EIIBC-GUT_N PF03612.14 CDI86801.1 - 0.82 9.4 15.0 1.3 8.8 15.0 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Pal1 PF08316.11 CDI86801.1 - 0.84 10.4 7.7 1.5 9.6 7.7 1.5 1 0 0 1 1 1 0 Pal1 cell morphology protein MMR1 PF08505.10 CDI86801.1 - 0.85 9.9 20.4 1.1 9.5 20.4 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Folate_carrier PF01770.18 CDI86801.1 - 0.92 8.2 9.4 1.3 7.7 9.4 1.3 1 0 0 1 1 1 0 Reduced folate carrier YABBY PF04690.13 CDI86801.1 - 0.98 10.0 15.1 1.4 9.5 15.1 1.2 1 0 0 1 1 1 0 YABBY protein ORC_WH_C PF18137.1 CDI86801.1 - 1 9.4 16.3 1.4 8.9 16.3 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Gti1_Pac2 PF09729.9 CDI86801.1 - 1.2 9.2 15.1 1.5 8.8 15.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF2828 PF11443.8 CDI86801.1 - 1.4 6.9 19.0 1.7 6.6 19.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Band_3_cyto PF07565.13 CDI86801.1 - 1.4 8.6 17.7 1.8 8.3 17.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PPL5 PF18168.1 CDI86801.1 - 1.5 8.0 12.9 2 7.6 12.9 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF4637 PF15470.6 CDI86801.1 - 1.7 8.4 11.8 2.5 7.8 11.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF3408 PF11888.8 CDI86801.1 - 1.7 8.8 19.1 2.8 8.1 19.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Folliculin PF11704.8 CDI86801.1 - 1.8 8.4 15.9 2.3 8.1 15.9 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport PIP5K PF01504.18 CDI86801.1 - 1.9 7.7 17.1 2.4 7.3 17.1 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase CSG2 PF16965.5 CDI86801.1 - 1.9 7.4 12.1 2.4 7.0 12.1 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4050 PF13259.6 CDI86801.1 - 1.9 8.7 16.5 3.4 8.0 16.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) TERB2 PF15101.6 CDI86801.1 - 2.2 8.3 27.2 3.2 7.8 27.2 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 MDM10 PF12519.8 CDI86801.1 - 2.2 7.0 16.8 2.9 6.6 16.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF2370 PF10176.9 CDI86801.1 - 2.7 7.6 11.3 4.1 7.0 11.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF2126 PF09899.9 CDI86801.1 - 2.8 5.9 14.5 3.6 5.5 14.5 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) UPF0565 PF10561.9 CDI86801.1 - 3.3 6.8 11.8 5 6.2 11.8 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 TraT PF05818.12 CDI86801.1 - 3.4 7.3 27.1 0.027 14.2 12.0 2.3 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein DUF2072 PF09845.9 CDI86801.1 - 4 7.7 15.9 5.6 7.2 15.9 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein Peroxin-13_N PF04088.13 CDI86801.1 - 4.5 7.5 11.3 7.7 6.8 11.3 1.4 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF4746 PF15928.5 CDI86801.1 - 4.6 6.6 14.7 6.8 6.0 14.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) EPL1 PF10513.9 CDI86801.1 - 5.5 7.4 21.4 8.5 6.7 21.4 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like GREB1 PF15782.5 CDI86801.1 - 5.6 3.9 18.9 6.8 3.7 18.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 CDI86801.1 - 6 4.9 17.3 7.3 4.6 17.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4471 PF14740.6 CDI86801.1 - 6.1 6.0 16.8 7.9 5.6 16.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) MDM31_MDM32 PF08118.11 CDI86801.1 - 6.3 5.3 15.8 8.7 4.9 15.8 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins NEMP PF10225.9 CDI86801.1 - 6.4 6.4 9.6 9 5.9 9.6 1.2 1 0 0 1 1 1 0 NEMP family Paramyxo_ncap PF00973.19 CDI86801.1 - 7 5.4 13.4 8.6 5.1 13.4 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein ATAD4 PF15321.6 CDI86801.1 - 7 8.1 13.8 11 7.4 13.8 1.3 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 Scs3p PF10261.9 CDI86801.1 - 7.1 6.1 8.4 10 5.6 8.4 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Baculo_PP31 PF05311.11 CDI86801.1 - 7.3 6.0 20.2 10 5.5 20.2 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF702 PF05142.12 CDI86801.1 - 7.6 7.0 20.5 20 5.6 20.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF702) PRC2_HTH_1 PF18118.1 CDI86801.1 - 7.8 7.4 15.1 12 6.7 15.1 1.2 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain DUF4834 PF16118.5 CDI86802.1 - 0.00025 22.0 1.3 0.00033 21.6 1.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) RskA PF10099.9 CDI86802.1 - 0.00032 21.0 0.7 0.00032 21.0 0.7 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF533 PF04391.12 CDI86802.1 - 0.0011 18.6 2.1 0.0011 18.6 2.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF533) Spt20 PF12090.8 CDI86802.1 - 0.0013 18.4 18.5 0.0014 18.3 18.5 1.1 1 0 0 1 1 1 1 Spt20 family DUF4131 PF13567.6 CDI86802.1 - 0.0027 17.4 0.0 0.0031 17.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) EphA2_TM PF14575.6 CDI86802.1 - 0.014 16.3 0.8 0.027 15.3 0.7 1.6 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Presenilin PF01080.17 CDI86802.1 - 0.014 14.2 0.2 0.014 14.2 0.2 1.1 1 0 0 1 1 1 0 Presenilin CobT PF06213.12 CDI86802.1 - 0.016 14.6 6.0 0.018 14.4 6.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT YABBY PF04690.13 CDI86802.1 - 0.021 15.4 0.8 0.021 15.4 0.8 1.1 1 0 0 1 1 1 0 YABBY protein FHIPEP PF00771.20 CDI86802.1 - 0.023 13.2 0.8 0.022 13.3 0.8 1.0 1 0 0 1 1 1 0 FHIPEP family Ctr PF04145.15 CDI86802.1 - 0.038 14.6 0.8 0.046 14.3 0.8 1.3 1 1 0 1 1 1 0 Ctr copper transporter family FAM176 PF14851.6 CDI86802.1 - 0.04 13.6 0.8 0.04 13.6 0.8 1.8 2 0 0 2 2 2 0 FAM176 family GWT1 PF06423.12 CDI86802.1 - 0.052 13.7 0.0 0.071 13.2 0.0 1.3 1 0 0 1 1 1 0 GWT1 ABC2_membrane_2 PF12679.7 CDI86802.1 - 0.065 12.5 0.1 0.068 12.4 0.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF3464 PF11947.8 CDI86802.1 - 0.082 12.7 2.2 0.094 12.5 2.2 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF4175 PF13779.6 CDI86802.1 - 0.083 10.8 13.1 0.084 10.8 13.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TFIIA PF03153.13 CDI86802.1 - 0.1 12.6 16.1 0.11 12.5 16.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DivIC PF04977.15 CDI86802.1 - 0.12 12.1 11.7 0.2 11.4 11.7 1.3 1 0 0 1 1 1 0 Septum formation initiator Suf PF05843.14 CDI86802.1 - 0.15 12.0 6.4 0.15 12.1 6.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DcuC PF03606.15 CDI86802.1 - 0.16 10.4 0.1 0.19 10.1 0.1 1.1 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier TMEM51 PF15345.6 CDI86802.1 - 0.17 11.7 14.7 0.055 13.3 11.1 1.8 1 1 1 2 2 2 0 Transmembrane protein 51 Orf78 PF06024.12 CDI86802.1 - 0.22 11.8 2.3 0.31 11.4 2.3 1.2 1 0 0 1 1 1 0 Orf78 (ac78) UPF0542 PF15086.6 CDI86802.1 - 0.28 11.1 1.0 0.59 10.1 1.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 PigN PF04987.14 CDI86802.1 - 0.53 9.1 1.4 0.69 8.7 1.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Conotoxin PF02950.17 CDI86802.1 - 1 10.4 6.2 0.14 13.2 1.9 1.7 2 0 0 2 2 1 0 Conotoxin Activator_LAG-3 PF11498.8 CDI86802.1 - 2.4 7.0 25.1 2.8 6.8 25.1 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Med3 PF11593.8 CDI86802.1 - 4.1 6.5 19.2 4.8 6.3 19.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Androgen_recep PF02166.16 CDI86802.1 - 4.6 6.0 19.7 5.3 5.8 19.7 1.1 1 0 0 1 1 1 0 Androgen receptor TERB2 PF15101.6 CDI86802.1 - 5 7.1 12.2 6.3 6.8 12.2 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF2722 PF10846.8 CDI86802.1 - 6.6 5.6 25.9 8 5.3 25.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) MscS_TM PF12794.7 CDI86802.1 - 6.7 5.5 7.6 5 5.9 6.4 1.4 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 UPF0560 PF10577.9 CDI86802.1 - 6.8 5.1 14.3 8.6 4.7 14.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF1129 PF06570.11 CDI86804.1 - 0.0068 15.9 4.8 0.0081 15.7 4.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) DUF2199 PF09965.9 CDI86804.1 - 0.036 14.1 0.7 0.041 14.0 0.7 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2199) Tmem26 PF09772.9 CDI86804.1 - 0.049 13.0 6.6 0.061 12.7 6.6 1.0 1 0 0 1 1 1 0 Transmembrane protein 26 CrgA PF06781.12 CDI86804.1 - 0.059 13.4 4.5 0.45 10.6 0.9 2.0 1 1 1 2 2 2 0 Cell division protein CrgA DUF1345 PF07077.11 CDI86804.1 - 0.061 13.0 1.0 0.065 12.9 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) Pex14_N PF04695.13 CDI86804.1 - 0.12 13.1 11.4 0.16 12.6 11.4 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region YbjM PF11045.8 CDI86804.1 - 0.13 12.4 4.5 0.22 11.7 4.5 1.4 1 1 0 1 1 1 0 Putative inner membrane protein of Enterobacteriaceae Orf78 PF06024.12 CDI86804.1 - 0.42 10.9 9.7 28 5.1 9.7 2.0 1 1 0 1 1 1 0 Orf78 (ac78) Folliculin PF11704.8 CDI86804.1 - 0.43 10.4 4.7 0.5 10.2 4.7 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport TFIIA PF03153.13 CDI86804.1 - 0.69 9.9 24.6 0.88 9.5 24.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PrsW-protease PF13367.6 CDI86804.1 - 0.78 9.1 3.1 0.91 8.9 0.6 1.9 1 1 1 2 2 2 0 PrsW family intramembrane metalloprotease SAM_decarbox PF01536.16 CDI86804.1 - 0.9 8.5 6.0 1 8.3 6.0 1.1 1 0 0 1 1 1 0 Adenosylmethionine decarboxylase INSIG PF07281.12 CDI86804.1 - 3.1 7.4 7.8 12 5.4 0.2 2.0 1 1 1 2 2 2 0 Insulin-induced protein (INSIG) 7tm_7 PF08395.12 CDI86804.1 - 8.1 5.5 15.0 9.2 5.3 15.0 1.0 1 0 0 1 1 1 0 7tm Chemosensory receptor Spt20 PF12090.8 CDI86805.1 - 0.00045 19.9 16.7 0.00045 19.9 16.7 11.4 7 2 2 9 9 9 2 Spt20 family BAF1_ABF1 PF04684.13 CDI86805.1 - 0.0035 16.5 8.6 0.0035 16.5 8.6 5.3 4 2 1 5 5 5 2 BAF1 / ABF1 chromatin reorganising factor SUIM_assoc PF16619.5 CDI86805.1 - 0.0071 16.4 7.7 0.0071 16.4 7.7 17.1 13 4 2 15 15 15 5 Unstructured region C-term to UIM in Ataxin3 Evr1_Alr PF04777.13 CDI86808.1 - 9.8e-12 45.2 0.1 1.1e-10 41.9 0.1 2.5 1 1 0 1 1 1 1 Erv1 / Alr family Thioredoxin PF00085.20 CDI86808.1 - 4.1e-05 23.5 0.0 8.8e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 CDI86808.1 - 0.01 15.8 0.0 0.026 14.4 0.0 1.7 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 CDI86808.1 - 0.091 13.2 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain LSM PF01423.22 CDI86811.1 - 4.4e-16 58.3 0.1 5.1e-16 58.1 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDI86811.1 - 5.2e-06 26.5 0.0 6.1e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 CDI86811.1 - 0.012 15.7 0.0 0.014 15.5 0.0 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain MTBP_C PF14920.6 CDI86811.1 - 0.096 12.4 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 MDM2-binding DUF4772 PF15997.5 CDI86811.1 - 0.12 12.9 0.0 0.15 12.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4772) TruB_C_2 PF16198.5 CDI86812.1 - 2e-21 75.9 0.6 3.3e-21 75.2 0.6 1.4 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 CDI86812.1 - 2.4e-21 75.5 1.2 4.8e-21 74.5 1.2 1.5 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 CDI86812.1 - 0.001 19.3 0.1 0.0048 17.1 0.0 2.1 2 0 0 2 2 2 1 UPF0113 PUA domain Coilin_N PF15862.5 CDI86812.1 - 0.0023 17.7 5.3 0.0031 17.3 5.3 1.2 1 0 0 1 1 1 1 Coilin N-terminus DUF4746 PF15928.5 CDI86812.1 - 0.29 10.5 8.1 0.44 9.9 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RNA_polI_A34 PF08208.11 CDI86812.1 - 1 9.4 19.2 1.4 8.9 19.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 CDI86812.1 - 4.7 7.0 13.2 5.7 6.7 13.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RskA PF10099.9 CDI86813.1 - 8.5e-08 32.7 3.9 8.5e-08 32.7 3.9 12.8 4 4 3 8 8 8 1 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI86813.1 - 0.00031 19.8 8.5 0.00031 19.8 8.5 8.7 6 3 2 9 9 9 2 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI86813.1 - 0.0049 16.5 19.8 0.0049 16.5 19.8 8.1 4 2 0 5 5 5 2 Spt20 family RskA PF10099.9 CDI86814.1 - 0.0018 18.6 0.1 0.0018 18.6 0.1 5.7 2 2 2 4 4 4 1 Anti-sigma-K factor rskA DUF2232 PF09991.9 CDI86815.1 - 0.0039 16.4 4.4 0.0045 16.2 4.4 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2232) RskA PF10099.9 CDI86815.1 - 0.0046 17.3 25.2 0.0066 16.8 25.2 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA TraT PF05818.12 CDI86815.1 - 0.015 15.0 7.8 0.02 14.6 7.8 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Topoisom_I_N PF02919.15 CDI86815.1 - 0.029 13.9 0.9 0.03 13.8 0.9 1.1 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Activator_LAG-3 PF11498.8 CDI86815.1 - 0.12 11.3 32.2 0.13 11.2 32.2 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Peptidase_S49_N PF08496.10 CDI86815.1 - 0.12 12.4 7.5 0.15 12.1 7.5 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Suf PF05843.14 CDI86815.1 - 0.14 12.2 14.6 0.14 12.2 14.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Connexin PF00029.19 CDI86815.1 - 0.14 11.9 2.1 0.13 12.0 2.1 1.1 1 0 0 1 1 1 0 Connexin DUF1682 PF07946.14 CDI86815.1 - 0.18 11.0 11.8 0.2 10.8 11.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) FAM199X PF15814.5 CDI86815.1 - 0.2 10.7 11.2 0.22 10.6 11.2 1.0 1 0 0 1 1 1 0 Protein family FAM199X TFIIA PF03153.13 CDI86815.1 - 0.2 11.6 36.3 0.23 11.4 36.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glt_symporter PF03616.14 CDI86815.1 - 0.2 10.3 3.0 0.24 10.0 3.0 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter PAS PF00989.25 CDI86815.1 - 0.41 10.7 6.2 0.76 9.8 6.2 1.5 1 1 0 1 1 1 0 PAS fold Orf78 PF06024.12 CDI86815.1 - 0.53 10.6 7.3 0.28 11.5 4.9 1.7 1 1 1 2 2 2 0 Orf78 (ac78) SID-1_RNA_chan PF13965.6 CDI86815.1 - 0.56 8.6 2.4 0.56 8.6 2.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 eIF-3_zeta PF05091.12 CDI86815.1 - 0.57 9.1 12.0 0.59 9.1 12.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spore_coat_CotO PF14153.6 CDI86815.1 - 0.64 9.9 17.5 0.78 9.6 17.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO EOS1 PF12326.8 CDI86815.1 - 0.68 9.9 3.3 0.75 9.7 3.3 1.2 1 0 0 1 1 1 0 N-glycosylation protein DUF4034 PF13226.6 CDI86815.1 - 0.7 9.2 16.7 0.83 9.0 16.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4034) BAF1_ABF1 PF04684.13 CDI86815.1 - 0.86 8.6 13.7 1 8.4 13.7 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FAM60A PF15396.6 CDI86815.1 - 0.87 9.5 6.1 0.92 9.5 6.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CLN3 PF02487.17 CDI86815.1 - 1.2 8.1 4.7 1.2 8.1 4.7 1.2 1 0 0 1 1 1 0 CLN3 protein DUF572 PF04502.13 CDI86815.1 - 1.2 8.6 12.1 1.4 8.5 12.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF2572 PF10833.8 CDI86815.1 - 1.4 8.7 13.5 1.7 8.4 13.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) Hydin_ADK PF17213.3 CDI86815.1 - 2 8.7 14.9 2.7 8.2 14.9 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain RR_TM4-6 PF06459.12 CDI86815.1 - 2 8.2 9.6 2.2 8.0 9.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 R_equi_Vir PF05526.11 CDI86815.1 - 2.3 8.0 11.2 3.2 7.6 11.2 1.2 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein EIF4E-T PF10477.9 CDI86815.1 - 2.4 6.9 15.8 2.4 6.9 15.8 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Plasmodium_Vir PF05795.11 CDI86815.1 - 2.7 7.3 3.9 2.4 7.5 3.9 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Neur_chan_memb PF02932.16 CDI86815.1 - 3.2 7.7 7.4 3.3 7.7 7.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.17 CDI86815.1 - 3.9 7.6 11.8 4.8 7.3 11.8 1.1 1 0 0 1 1 1 0 DDHD domain Peptidase_S15 PF02129.18 CDI86815.1 - 4.2 6.9 12.6 5.2 6.6 12.6 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Serinc PF03348.15 CDI86815.1 - 4.7 6.0 8.0 5.6 5.8 8.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Presenilin PF01080.17 CDI86815.1 - 5.8 5.6 15.5 6.4 5.4 15.5 1.1 1 0 0 1 1 1 0 Presenilin Sec16 PF12932.7 CDI86815.1 - 6.4 7.4 10.0 13 6.4 10.0 1.7 1 1 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region EMC3_TMCO1 PF01956.16 CDI86815.1 - 7.1 6.3 8.6 8.7 6.1 8.6 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Lipoprotein_2 PF00921.17 CDI86815.1 - 9.9 5.6 13.9 12 5.4 13.9 1.1 1 0 0 1 1 1 0 Borrelia lipoprotein Spt20 PF12090.8 CDI86815.1 - 9.9 5.7 35.0 16 5.0 35.0 1.3 1 0 0 1 1 1 0 Spt20 family Latrophilin PF02354.16 CDI86816.1 - 0.59 9.2 16.4 0.71 8.9 16.4 1.0 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region DUF3381 PF11861.8 CDI86816.1 - 2.9 7.7 26.1 3.9 7.2 4.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) SLC12 PF03522.15 CDI86816.1 - 3.1 6.7 19.0 5 6.0 19.0 1.3 1 0 0 1 1 1 0 Solute carrier family 12 CCSAP PF15748.5 CDI86816.1 - 3.7 7.7 24.5 4.9 7.2 24.5 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Hid1 PF12722.7 CDI86816.1 - 4.1 5.4 21.9 5 5.1 21.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PAT1 PF09770.9 CDI86816.1 - 4.2 5.5 35.8 5.2 5.2 35.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MAT1 PF06391.13 CDI86816.1 - 7.7 6.3 26.6 2 8.2 17.5 2.0 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 BCL9 PF11502.8 CDI86817.1 - 0.059 13.2 0.0 0.091 12.6 0.0 1.3 1 0 0 1 1 1 0 B-cell lymphoma 9 protein Fibrillin_U_N PF18193.1 CDI86817.1 - 2.7 8.2 3.6 59 3.9 0.3 2.9 1 1 2 3 3 3 0 Fibrillin 1 unique N-terminal domain Rad21_Rec8 PF04824.16 CDI86818.1 - 0.00013 21.2 0.3 0.00032 19.9 0.3 1.7 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein AAA_23 PF13476.6 CDI86818.1 - 0.025 15.1 19.4 0.29 11.6 4.8 2.4 2 0 0 2 2 2 0 AAA domain DUF1687 PF07955.11 CDI86819.1 - 0.016 15.7 5.8 0.046 14.2 5.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1687) DUF2371 PF10177.9 CDI86819.1 - 0.07 13.3 0.2 1.2 9.3 0.0 2.4 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) cwf18 PF08315.12 CDI86819.1 - 0.29 11.8 7.5 0.21 12.3 5.8 1.5 1 1 0 1 1 1 0 cwf18 pre-mRNA splicing factor TFIIA PF03153.13 CDI86819.1 - 0.3 11.0 22.8 0.44 10.5 22.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit UCR_Fe-S_N PF10399.9 CDI86819.1 - 0.67 9.3 6.4 1.5 8.2 6.4 1.6 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Tetraspanin PF00335.20 CDI86819.1 - 1.6 8.4 3.9 2.9 7.5 3.9 1.3 1 1 0 1 1 1 0 Tetraspanin family SOG2 PF10428.9 CDI86819.1 - 4.1 6.5 27.6 5.9 6.0 27.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Adaptin_binding PF10199.9 CDI86820.1 - 0.00073 20.1 3.0 0.00073 20.1 3.0 4.0 1 1 2 3 3 3 1 Alpha and gamma adaptin binding protein p34 IMUP PF15761.5 CDI86820.1 - 0.0065 17.1 1.1 0.0065 17.1 1.1 3.7 3 2 0 3 3 3 1 Immortalisation up-regulated protein LMBR1 PF04791.16 CDI86820.1 - 0.026 13.4 11.9 0.043 12.7 11.9 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein V_ATPase_I PF01496.19 CDI86820.1 - 0.26 9.2 37.6 0.18 9.7 32.9 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family EcsB PF05975.12 CDI86820.1 - 0.27 10.0 8.0 8.1 5.2 0.0 2.1 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB Spt20 PF12090.8 CDI86821.1 - 0.058 13.0 22.8 0.071 12.7 22.8 1.1 1 0 0 1 1 1 0 Spt20 family ANAPC_CDC26 PF10471.9 CDI86821.1 - 0.083 13.7 17.1 0.11 13.4 17.1 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 DUF2722 PF10846.8 CDI86821.1 - 0.11 11.4 18.1 0.12 11.3 18.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF1744 PF08490.12 CDI86821.1 - 0.16 10.5 2.7 0.18 10.4 2.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1744) Med15 PF09606.10 CDI86821.1 - 0.52 8.9 21.6 0.55 8.8 21.6 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Sec62 PF03839.16 CDI86821.1 - 0.75 9.3 5.6 0.84 9.1 5.6 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4407 PF14362.6 CDI86821.1 - 1 8.6 5.9 1 8.7 5.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TFIIA PF03153.13 CDI86821.1 - 1.3 8.9 20.2 1.4 8.9 20.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CobT PF06213.12 CDI86821.1 - 2.2 7.6 10.7 2.5 7.4 10.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT UPF0560 PF10577.9 CDI86821.1 - 2.6 6.5 12.4 2.4 6.6 12.4 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF853 PF05872.12 CDI86821.1 - 2.7 6.5 8.1 2.8 6.4 8.1 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Presenilin PF01080.17 CDI86821.1 - 2.7 6.7 6.4 2.8 6.6 6.4 1.1 1 0 0 1 1 1 0 Presenilin MscS_TM PF12794.7 CDI86821.1 - 4.1 6.2 5.1 3.6 6.4 5.1 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Suf PF05843.14 CDI86821.1 - 4.4 7.2 9.1 3.9 7.4 9.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CLN3 PF02487.17 CDI86821.1 - 6.2 5.7 4.7 6.3 5.7 4.7 1.0 1 0 0 1 1 1 0 CLN3 protein TMEM51 PF15345.6 CDI86821.1 - 6.6 6.5 8.8 6 6.6 8.8 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 SARAF PF06682.12 CDI86823.1 - 0.0015 18.2 8.0 0.0015 18.2 8.0 6.0 3 3 1 4 4 4 1 SOCE-associated regulatory factor of calcium homoeostasis FAST_1 PF06743.15 CDI86823.1 - 0.0025 17.7 6.1 0.27 11.2 0.1 3.3 3 0 0 3 3 3 2 FAST kinase-like protein, subdomain 1 Methyltransf_23 PF13489.6 CDI86823.1 - 0.12 12.2 0.1 0.12 12.2 0.1 5.2 4 1 1 5 5 5 0 Methyltransferase domain Me-amine-dh_H PF06433.11 CDI86823.1 - 0.41 9.4 0.0 0.41 9.4 0.0 2.0 2 0 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) SR-25 PF10500.9 CDI86823.1 - 0.5 10.0 92.6 0.051 13.2 8.9 5.5 4 1 1 5 5 5 0 Nuclear RNA-splicing-associated protein ALG11_N PF15924.5 CDI86825.1 - 1.1e-12 48.5 9.1 1.3e-07 31.9 0.0 4.8 3 2 0 3 3 3 2 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 CDI86825.1 - 3.1e-06 26.8 0.4 3.1e-06 26.8 0.4 3.1 3 0 0 3 3 3 1 Glycosyl transferases group 1 DUF2722 PF10846.8 CDI86825.1 - 8.8e-05 21.6 9.9 8.8e-05 21.6 9.9 7.8 4 3 3 7 7 7 1 Protein of unknown function (DUF2722) SDA1 PF05285.12 CDI86825.1 - 0.0014 18.1 1.1 0.0014 18.1 1.1 4.3 3 1 1 4 4 4 2 SDA1 Glyco_trans_1_4 PF13692.6 CDI86825.1 - 0.002 18.5 0.7 0.002 18.5 0.7 3.3 3 1 1 4 4 4 1 Glycosyl transferases group 1 Gemini_mov PF01708.16 CDI86825.1 - 0.013 15.2 0.7 0.013 15.2 0.7 4.9 7 0 0 7 7 7 0 Geminivirus putative movement protein DUF966 PF06136.13 CDI86825.1 - 2 8.1 55.3 0.91 9.2 0.1 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF966) V_ATPase_I PF01496.19 CDI86825.1 - 8.7 4.1 62.4 0.93 7.3 2.5 4.1 4 0 0 4 4 4 0 V-type ATPase 116kDa subunit family CBFD_NFYB_HMF PF00808.23 CDI86826.1 - 5.7e-06 26.5 0.5 5.7e-06 26.5 0.5 2.0 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDI86826.1 - 0.0022 18.4 1.0 0.0022 18.4 1.0 2.2 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIIA PF03153.13 CDI86826.1 - 0.012 15.7 20.2 0.017 15.1 20.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CENP-T_C PF15511.6 CDI86826.1 - 0.02 15.0 1.0 0.049 13.8 1.0 1.7 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold DUF3337 PF11816.8 CDI86826.1 - 0.11 12.3 0.2 0.22 11.4 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) Imm5 PF14423.6 CDI86826.1 - 0.19 12.0 3.9 0.43 10.8 3.9 1.7 1 0 0 1 1 1 0 Immunity protein Imm5 CENP-B_dimeris PF09026.10 CDI86827.1 - 0.0024 18.3 3.1 0.0024 18.3 3.1 3.4 3 0 0 3 3 3 1 Centromere protein B dimerisation domain Caldesmon PF02029.15 CDI86827.1 - 0.0039 16.0 29.8 0.0039 16.0 29.8 3.2 2 1 0 3 3 3 1 Caldesmon DUF3299 PF11736.8 CDI86828.1 - 0.21 11.6 8.7 0.28 11.2 8.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3299) AAA_28 PF13521.6 CDI86828.1 - 0.78 10.0 5.1 0.92 9.7 5.1 1.2 1 0 0 1 1 1 0 AAA domain Peptidase_U57 PF05582.12 CDI86828.1 - 1.1 8.5 8.9 1.1 8.4 8.9 1.0 1 0 0 1 1 1 0 YabG peptidase U57 Spc24 PF08286.11 CDI86828.1 - 2.3 8.5 13.8 2.9 8.2 13.8 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF4225 PF13988.6 CDI86828.1 - 2.4 7.7 7.6 2.6 7.6 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4225) Exonuc_VII_L PF02601.15 CDI86828.1 - 4.2 6.9 18.1 4.1 6.9 18.1 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Endonuc_Holl PF10107.9 CDI86828.1 - 6.7 6.5 10.7 6.7 6.5 10.7 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Connexin PF00029.19 CDI86828.1 - 7.6 6.2 8.7 7.6 6.2 8.7 1.0 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 CDI86828.1 - 7.8 4.3 12.6 7.7 4.3 12.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TRAP_alpha PF03896.16 CDI86829.1 - 9.8 5.3 15.8 11 5.1 15.8 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Ribosomal_60s PF00428.19 CDI86830.1 - 5.7e-22 78.1 10.8 7.1e-22 77.8 10.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3138 PF11336.8 CDI86830.1 - 1.6 7.3 5.6 1.6 7.3 5.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) SID-1_RNA_chan PF13965.6 CDI86832.1 - 0.15 10.4 4.2 0.22 9.9 4.2 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2722 PF10846.8 CDI86832.1 - 0.33 9.8 51.0 0.0097 14.9 25.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) FSA_C PF10479.9 CDI86832.1 - 0.82 7.7 9.9 1.1 7.3 9.9 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus MAM33 PF02330.16 CDI86832.1 - 1.8 8.5 17.6 5.6 6.9 10.8 2.1 2 0 0 2 2 2 0 Mitochondrial glycoprotein Rsc14 PF08586.10 CDI86832.1 - 2.3 9.1 13.5 18 6.2 0.1 2.2 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit DUF4770 PF15994.5 CDI86832.1 - 3.8 7.7 22.5 4.6 7.4 12.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) FAM176 PF14851.6 CDI86832.1 - 4.4 7.0 12.3 11 5.7 8.3 2.1 2 0 0 2 2 2 0 FAM176 family BAF1_ABF1 PF04684.13 CDI86832.1 - 4.7 6.2 27.6 6.4 5.7 27.6 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor NUDE_C PF04880.13 CDI86832.1 - 5.7 7.4 19.5 7.8 6.9 19.5 1.2 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Ndc1_Nup PF09531.10 CDI86832.1 - 6.2 5.4 31.1 7.8 5.1 31.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 CDI86833.1 - 0.0007 18.0 53.2 0.0009 17.7 53.2 1.3 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Med15 PF09606.10 CDI86833.1 - 0.081 11.6 72.4 0.14 10.9 72.4 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4667 PF15700.5 CDI86833.1 - 3.6 7.6 50.4 0.041 14.0 5.6 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4667) RskA PF10099.9 CDI86833.1 - 5.3 7.3 59.8 6.6 7.0 17.9 2.9 1 1 1 2 2 2 0 Anti-sigma-K factor rskA ALMT PF11744.8 CDI86834.1 - 0.14 11.0 23.0 0.23 10.3 23.0 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter LMBR1 PF04791.16 CDI86834.1 - 0.85 8.5 9.5 0.86 8.4 9.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Hamartin PF04388.12 CDI86834.1 - 1.2 7.7 25.1 1.4 7.5 25.1 1.2 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 CDI86834.1 - 3.4 4.7 31.1 4.6 4.2 31.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Asp-B-Hydro_N PF05279.11 CDI86834.1 - 4.9 7.2 28.6 9.9 6.2 28.6 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CDC45 PF02724.14 CDI86834.1 - 5.8 5.1 29.5 8.6 4.5 29.5 1.2 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI86834.1 - 7 5.6 31.7 12 4.8 31.7 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Suf PF05843.14 CDI86837.1 - 0.15 12.0 16.5 0.19 11.7 16.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Dehydrin PF00257.19 CDI86837.1 - 0.66 10.5 13.6 0.14 12.7 6.5 2.2 2 0 0 2 2 2 0 Dehydrin Pet20 PF08692.10 CDI86837.1 - 0.75 10.5 4.6 0.97 10.2 0.3 2.1 2 0 0 2 2 2 0 Mitochondrial protein Pet20 DUF572 PF04502.13 CDI86837.1 - 1.9 8.0 14.2 2.4 7.7 14.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) STAC2_u1 PF16664.5 CDI86837.1 - 3.2 8.2 17.6 0.5 10.8 9.4 2.2 1 1 1 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Menin PF05053.13 CDI86837.1 - 4.2 5.6 16.9 5.1 5.3 16.9 1.0 1 0 0 1 1 1 0 Menin SLC12 PF03522.15 CDI86837.1 - 4.5 6.2 12.0 5.6 5.9 12.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF4551 PF15087.6 CDI86837.1 - 4.8 5.9 14.1 5.3 5.7 14.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DASH_Dam1 PF08653.10 CDI86839.1 - 5.7 6.8 8.8 0.54 10.1 2.7 2.4 2 0 0 2 2 2 0 DASH complex subunit Dam1 DAG_kinase_N PF14513.6 CDI86840.1 - 0.22 11.7 31.6 0.26 11.5 31.6 1.0 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus CDC45 PF02724.14 CDI86840.1 - 0.36 9.1 29.5 0.42 8.9 29.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Pex16 PF08610.10 CDI86840.1 - 0.4 9.8 14.1 0.41 9.8 14.1 1.0 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) NPR3 PF03666.13 CDI86840.1 - 0.46 9.2 30.7 0.52 9.0 30.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Gti1_Pac2 PF09729.9 CDI86840.1 - 0.48 10.5 27.0 0.58 10.2 27.0 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family TRAP_alpha PF03896.16 CDI86840.1 - 0.52 9.5 14.6 0.62 9.2 14.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DDRGK PF09756.9 CDI86840.1 - 0.69 9.5 42.4 0.87 9.1 42.4 1.2 1 0 0 1 1 1 0 DDRGK domain Peptidase_S64 PF08192.11 CDI86840.1 - 1 7.8 29.3 1 7.8 29.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 SLC12 PF03522.15 CDI86840.1 - 1 8.3 35.4 1.1 8.2 35.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4050 PF13259.6 CDI86840.1 - 1.3 9.4 30.2 1.6 9.0 30.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) CLN3 PF02487.17 CDI86840.1 - 1.5 7.8 26.4 1.7 7.6 26.4 1.1 1 0 0 1 1 1 0 CLN3 protein ALMT PF11744.8 CDI86840.1 - 1.5 7.6 28.4 1.5 7.5 28.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3807 PF12720.7 CDI86840.1 - 1.5 9.0 43.0 2 8.7 43.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Tim54 PF11711.8 CDI86840.1 - 1.5 7.5 28.4 2.5 6.8 28.4 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF913 PF06025.12 CDI86840.1 - 1.6 7.6 21.3 2.1 7.2 21.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 CDI86840.1 - 1.9 8.5 28.0 2.2 8.2 28.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CCSAP PF15748.5 CDI86840.1 - 1.9 8.6 37.7 2.2 8.4 37.7 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated MCM_bind PF09739.9 CDI86840.1 - 4.1 5.7 33.1 4.7 5.5 33.1 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF4045 PF13254.6 CDI86840.1 - 4.1 6.9 30.3 4.7 6.7 30.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CSG2 PF16965.5 CDI86840.1 - 4.8 6.0 19.6 6.3 5.6 19.6 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator DUF572 PF04502.13 CDI86840.1 - 5 6.7 29.7 6.1 6.4 29.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Rtf2 PF04641.12 CDI86840.1 - 5.2 6.4 30.6 6.4 6.1 30.6 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger DUF4746 PF15928.5 CDI86840.1 - 5.8 6.2 26.8 7 6.0 26.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Otopetrin PF03189.13 CDI86840.1 - 6.8 5.4 24.0 7.1 5.3 24.0 1.1 1 0 0 1 1 1 0 Otopetrin AAA_11 PF13086.6 CDI86840.1 - 7.6 6.2 33.8 8.7 6.0 33.8 1.0 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 CDI86840.1 - 8.1 5.1 45.4 9.9 4.8 45.4 1.0 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 CDI86840.1 - 8.8 5.4 22.2 9.4 5.3 22.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2370 PF10176.9 CDI86840.1 - 8.9 5.9 19.1 11 5.6 19.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Paramyxo_ncap PF00973.19 CDI86840.1 - 9 5.1 30.2 9.9 4.9 30.2 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein BORG_CEP PF14957.6 CDI86840.1 - 9 7.5 25.2 10 7.3 25.2 1.2 1 0 0 1 1 1 0 Cdc42 effector SART-1 PF03343.13 CDI86840.1 - 9.2 4.7 40.2 9.9 4.6 40.2 1.0 1 0 0 1 1 1 0 SART-1 family Endostatin PF06482.11 CDI86840.1 - 9.3 5.6 33.2 11 5.3 33.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Hid1 PF12722.7 CDI86840.1 - 9.7 4.2 32.9 11 4.0 32.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Velvet PF11754.8 CDI86840.1 - 10 6.0 35.0 12 5.8 35.0 1.1 1 0 0 1 1 1 0 Velvet factor DUF2722 PF10846.8 CDI86841.1 - 0.11 11.4 10.4 0.12 11.3 10.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI86841.1 - 0.14 11.7 16.2 0.14 11.8 16.2 1.1 1 0 0 1 1 1 0 Spt20 family MITF_TFEB_C_3_N PF15951.5 CDI86841.1 - 0.17 12.5 16.4 0.19 12.3 16.4 1.2 1 0 0 1 1 1 0 MITF/TFEB/TFEC/TFE3 N-terminus FAM163 PF15069.6 CDI86841.1 - 0.24 11.8 2.4 0.28 11.6 2.4 1.1 1 0 0 1 1 1 0 FAM163 family FTZ PF03867.14 CDI86841.1 - 0.39 10.2 10.6 0.44 10.0 10.6 1.0 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region TFIIA PF03153.13 CDI86841.1 - 0.4 10.6 15.0 0.41 10.6 15.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IER PF05760.12 CDI86841.1 - 0.7 10.1 9.9 0.77 10.0 9.9 1.1 1 0 0 1 1 1 0 Immediate early response protein (IER) DivIC PF04977.15 CDI86841.1 - 4.4 7.1 12.0 5.3 6.9 12.0 1.2 1 0 0 1 1 1 0 Septum formation initiator MFMR_assoc PF16596.5 CDI86843.1 - 2.7 8.5 11.5 2.1 8.8 10.5 1.3 1 1 0 1 1 1 0 Disordered region downstream of MFMR Pet20 PF08692.10 CDI86844.1 - 0.1 13.3 3.6 0.12 13.1 3.6 1.1 1 0 0 1 1 1 0 Mitochondrial protein Pet20 SelP_N PF04592.14 CDI86844.1 - 0.41 10.0 25.9 0.47 9.8 25.9 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Peptidase_S49_N PF08496.10 CDI86844.1 - 4.3 7.4 12.3 4.7 7.3 12.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Gti1_Pac2 PF09729.9 CDI86844.1 - 6.2 6.9 10.8 6.7 6.8 10.8 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family SUIM_assoc PF16619.5 CDI86845.1 - 2.8 8.1 29.1 0.23 11.5 0.3 3.3 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 SR-25 PF10500.9 CDI86845.1 - 3.7 7.1 20.7 0.14 11.8 10.5 2.8 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein BUD22 PF09073.10 CDI86846.1 - 0.00078 18.9 35.0 0.00097 18.6 35.0 1.1 1 0 0 1 1 1 1 BUD22 SWI-SNF_Ssr4 PF08549.10 CDI86846.1 - 0.0021 16.8 42.0 0.0025 16.5 42.0 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1750) GREB1 PF15782.5 CDI86846.1 - 0.0022 15.2 40.9 0.0024 15.1 40.9 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 CDI86846.1 - 0.0027 16.4 38.5 0.0033 16.1 38.5 1.1 1 0 0 1 1 1 1 Macoilin family DUF4045 PF13254.6 CDI86846.1 - 0.028 14.1 38.8 0.037 13.7 38.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Dapper PF15268.6 CDI86846.1 - 0.032 13.1 51.9 0.036 12.9 51.9 1.0 1 0 0 1 1 1 0 Dapper PAT1 PF09770.9 CDI86846.1 - 0.043 12.1 58.1 0.054 11.8 58.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Sin_N PF04801.13 CDI86846.1 - 0.088 12.0 54.8 0.11 11.7 54.8 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Draxin PF15550.6 CDI86846.1 - 0.7 9.7 29.0 0.87 9.4 29.0 1.2 1 0 0 1 1 1 0 Draxin TFIIF_alpha PF05793.12 CDI86846.1 - 0.71 8.4 38.1 1 7.9 38.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Asp-B-Hydro_N PF05279.11 CDI86846.1 - 0.85 9.6 38.0 1.2 9.2 38.0 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SOBP PF15279.6 CDI86846.1 - 1.5 9.4 40.8 2.2 8.8 40.8 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein WDCP PF15390.6 CDI86846.1 - 4.2 5.6 37.9 5.3 5.3 37.9 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Borrelia_P83 PF05262.11 CDI86846.1 - 5.9 5.3 42.9 6.8 5.1 42.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SR-25 PF10500.9 CDI86848.1 - 0.00043 20.0 9.9 0.00043 20.0 9.9 2.4 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein Cwf_Cwc_15 PF04889.12 CDI86848.1 - 0.0005 19.9 25.9 0.00064 19.5 25.9 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein BIV_Env PF05858.12 CDI86848.1 - 0.0013 17.0 3.5 0.0013 17.0 3.5 1.4 1 1 0 1 1 1 1 Bovine immunodeficiency virus surface protein (SU) KCH PF16944.5 CDI86848.1 - 0.028 14.2 0.4 0.028 14.2 0.4 2.5 2 1 1 3 3 3 0 Fungal potassium channel Baculo_PP31 PF05311.11 CDI86848.1 - 0.18 11.2 26.5 0.78 9.2 14.5 2.2 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Lin-8 PF03353.15 CDI86848.1 - 0.29 10.7 35.6 0.036 13.6 23.8 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist LysE PF01810.18 CDI86848.1 - 0.58 9.6 3.0 22 4.4 0.0 2.9 3 0 0 3 3 3 0 LysE type translocator Sec16 PF12932.7 CDI86848.1 - 2 9.0 22.6 0.042 14.4 13.2 2.3 1 1 1 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region Hamartin PF04388.12 CDI86848.1 - 5.1 5.6 34.1 6.6 5.3 34.1 1.1 1 0 0 1 1 1 0 Hamartin protein DUF3807 PF12720.7 CDI86848.1 - 6.1 7.1 40.7 8.6 6.6 25.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) RRM_1 PF00076.22 CDI86849.1 - 0.00034 20.4 0.0 0.00066 19.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDI86849.1 - 0.0035 17.2 0.0 0.0083 16.0 0.0 1.6 1 0 0 1 1 1 1 Occluded RNA-recognition motif DUF4366 PF14283.6 CDI86849.1 - 0.2 11.7 3.4 1.5 8.8 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) DUF4667 PF15700.5 CDI86849.1 - 0.8 9.7 16.9 0.17 12.0 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) RRM_3 PF08777.11 CDI86849.1 - 1.8 8.7 0.0 1.8 8.7 0.0 2.8 3 0 0 3 3 3 0 RNA binding motif PepSY_TM PF03929.16 CDI86849.1 - 3.1 7.4 9.0 7.6 6.1 3.8 2.3 2 0 0 2 2 2 0 PepSY-associated TM region Ndc1_Nup PF09531.10 CDI86849.1 - 4.4 5.9 12.2 18 3.9 10.8 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup ADK PF00406.22 CDI86850.1 - 1.4e-20 74.0 0.0 4.2e-17 62.6 0.0 3.2 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CDI86850.1 - 8.6e-11 42.4 0.8 5.4e-06 26.9 0.0 2.8 2 1 1 3 3 2 2 AAA domain AAA_18 PF13238.6 CDI86850.1 - 4.9e-07 30.3 0.0 5.1e-05 23.8 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CDI86850.1 - 4.9e-05 23.5 3.1 5.6e-05 23.3 0.0 2.6 2 1 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 CDI86850.1 - 0.0018 18.1 0.0 0.0058 16.4 0.0 1.8 2 0 0 2 2 2 1 Cytidylate kinase Spt20 PF12090.8 CDI86850.1 - 0.0018 17.9 7.2 0.0018 17.9 7.2 2.3 2 0 0 2 2 2 2 Spt20 family KTI12 PF08433.10 CDI86850.1 - 0.0026 17.2 0.1 0.0026 17.2 0.1 2.3 2 1 0 2 2 2 1 Chromatin associated protein KTI12 AAA_28 PF13521.6 CDI86850.1 - 0.014 15.6 0.0 0.014 15.6 0.0 2.5 2 1 0 2 2 2 0 AAA domain GET2 PF08690.10 CDI86850.1 - 0.015 15.0 3.2 0.015 15.0 3.2 2.3 2 1 0 2 2 2 0 GET complex subunit GET2 Mg_chelatase PF01078.21 CDI86850.1 - 0.027 13.9 0.0 0.027 13.9 0.0 2.2 2 1 1 3 3 3 0 Magnesium chelatase, subunit ChlI Orf78 PF06024.12 CDI86850.1 - 0.081 13.2 0.9 0.21 11.9 0.1 2.0 2 0 0 2 2 2 0 Orf78 (ac78) DUF3270 PF11674.8 CDI86850.1 - 0.92 9.7 7.3 0.053 13.7 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) dsDNA_bind PF01984.20 CDI86850.1 - 2.7 8.3 18.0 7.5 6.9 0.8 2.8 3 0 0 3 3 3 0 Double-stranded DNA-binding domain EphA2_TM PF14575.6 CDI86850.1 - 2.9 8.8 4.0 29 5.6 2.1 2.9 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain RAB3GAP2_N PF14655.6 CDI86850.1 - 4.5 6.4 7.8 2.9 7.1 3.3 2.1 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Suf PF05843.14 CDI86850.1 - 8.9 6.2 9.7 16 5.4 3.8 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) SR-25 PF10500.9 CDI86851.1 - 0.00013 21.7 18.5 0.00014 21.6 18.5 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Di19_C PF14571.6 CDI86851.1 - 0.2 12.2 15.4 0.23 12.0 15.4 1.1 1 0 0 1 1 1 0 Stress-induced protein Di19, C-terminal Pex14_N PF04695.13 CDI86851.1 - 0.21 12.2 27.1 0.28 11.8 27.1 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region THOC2_N PF16134.5 CDI86851.1 - 0.23 10.0 14.1 0.26 9.8 14.1 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus TCP PF03634.13 CDI86851.1 - 0.29 11.7 18.7 0.33 11.5 18.7 1.1 1 0 0 1 1 1 0 TCP family transcription factor DUF5523 PF17661.1 CDI86851.1 - 0.51 10.0 18.0 0.54 9.9 18.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) CCSAP PF15748.5 CDI86851.1 - 1.2 9.2 21.7 1.4 9.1 21.7 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CNDH2_C PF16858.5 CDI86851.1 - 2 8.2 19.4 2.4 8.0 19.4 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CTU2 PF10288.9 CDI86851.1 - 2.2 8.6 17.3 2.9 8.2 17.3 1.3 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 eIF-3_zeta PF05091.12 CDI86851.1 - 2.6 6.9 18.8 2.7 6.9 18.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Velvet PF11754.8 CDI86851.1 - 2.8 7.8 23.2 3 7.7 23.2 1.0 1 0 0 1 1 1 0 Velvet factor Presenilin PF01080.17 CDI86851.1 - 9.1 4.9 26.2 9.5 4.9 26.2 1.0 1 0 0 1 1 1 0 Presenilin DUF4175 PF13779.6 CDI86851.1 - 9.1 4.0 33.9 8.9 4.1 33.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Endostatin PF06482.11 CDI86851.1 - 9.2 5.6 17.6 9.7 5.6 17.6 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin N6_N4_Mtase PF01555.18 CDI86852.1 - 0.17 11.6 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 DNA methylase Otopetrin PF03189.13 CDI86853.1 - 5.7e-05 22.1 0.0 0.099 11.4 0.0 4.3 2 2 0 2 2 2 1 Otopetrin BUD22 PF09073.10 CDI86853.1 - 0.00071 19.0 4.3 0.00071 19.0 4.3 7.5 7 1 0 7 7 7 3 BUD22 RskA PF10099.9 CDI86853.1 - 0.0059 16.9 3.1 0.0059 16.9 3.1 20.1 7 6 8 15 15 15 2 Anti-sigma-K factor rskA TF_Zn_Ribbon PF08271.12 CDI86853.1 - 0.42 10.2 1.3 1.2 8.7 1.3 1.8 1 1 0 1 1 1 0 TFIIB zinc-binding NUT PF12881.7 CDI86854.1 - 0.014 13.8 0.3 0.015 13.8 0.3 1.2 1 0 0 1 1 1 0 NUT protein Folliculin PF11704.8 CDI86854.1 - 0.028 14.3 0.7 0.056 13.3 0.7 1.4 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Presenilin PF01080.17 CDI86854.1 - 0.068 11.9 1.2 0.091 11.5 1.2 1.1 1 0 0 1 1 1 0 Presenilin Secretin_N_2 PF07655.13 CDI86854.1 - 2.2 8.9 12.4 5.4 7.6 8.3 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain DUF3371 PF11851.8 CDI86855.1 - 0.00026 22.1 2.8 0.00026 22.1 2.8 5.0 3 2 1 4 4 4 2 Domain of unknown function (DUF3371) Synaptobrevin PF00957.21 CDI86855.1 - 0.076 12.8 1.6 0.28 11.0 1.6 1.9 1 0 0 1 1 1 0 Synaptobrevin PP2C PF00481.21 CDI86856.1 - 1.3e-59 201.9 12.9 5.3e-52 177.0 0.0 4.8 5 0 0 5 5 5 3 Protein phosphatase 2C Proton_antipo_C PF01010.19 CDI86856.1 - 9.5 5.8 5.1 18 4.9 5.1 1.3 1 0 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus Cytochrom_B561 PF03188.16 CDI86857.1 - 8.7e-27 93.9 9.4 8.7e-27 93.9 9.4 1.9 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 MIG-14_Wnt-bd PF06664.12 CDI86857.1 - 0.0048 16.2 1.1 0.0057 15.9 1.1 1.3 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion Ost4 PF10215.9 CDI86857.1 - 0.11 12.4 7.9 0.48 10.3 0.8 2.7 2 0 0 2 2 2 0 Oligosaccaryltransferase Ni_hydr_CYTB PF01292.20 CDI86857.1 - 1.4 8.4 12.4 0.087 12.4 4.8 2.2 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 DUF4079 PF13301.6 CDI86857.1 - 4.6 7.4 7.9 1.1 9.5 1.7 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF4079) DDHD PF02862.17 CDI86858.1 - 0.0074 16.5 1.0 0.019 15.1 0.1 1.9 2 0 0 2 2 2 1 DDHD domain DUF4834 PF16118.5 CDI86858.1 - 0.0094 16.9 1.9 0.0094 16.9 1.9 2.0 2 0 0 2 2 1 1 Domain of unknown function (DUF4834) Pal1 PF08316.11 CDI86858.1 - 0.011 16.5 1.0 0.027 15.2 1.0 1.7 1 0 0 1 1 1 0 Pal1 cell morphology protein FAST_1 PF06743.15 CDI86858.1 - 0.035 14.1 0.1 0.37 10.8 0.0 2.6 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 CobT PF06213.12 CDI86858.1 - 0.049 13.0 9.7 0.093 12.1 9.7 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FHIPEP PF00771.20 CDI86858.1 - 0.15 10.5 1.1 0.21 10.0 1.1 1.1 1 0 0 1 1 1 0 FHIPEP family TFIIA PF03153.13 CDI86858.1 - 0.29 11.1 27.0 0.046 13.7 21.4 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4471 PF14740.6 CDI86858.1 - 0.3 10.3 3.2 0.46 9.7 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) Spt20 PF12090.8 CDI86858.1 - 0.37 10.4 28.9 0.81 9.3 28.9 1.5 1 0 0 1 1 1 0 Spt20 family SpoIIP PF07454.11 CDI86858.1 - 0.41 10.1 6.6 0.67 9.4 6.6 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CLN3 PF02487.17 CDI86858.1 - 1.4 7.9 2.3 2.2 7.2 2.3 1.3 1 0 0 1 1 1 0 CLN3 protein DUF775 PF05603.12 CDI86858.1 - 1.5 8.3 8.2 3 7.3 8.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF775) PAT1 PF09770.9 CDI86858.1 - 1.9 6.7 14.3 3.5 5.8 14.3 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Connexin PF00029.19 CDI86858.1 - 1.9 8.2 4.6 3.6 7.3 4.6 1.3 1 0 0 1 1 1 0 Connexin CPSF100_C PF13299.6 CDI86858.1 - 2.1 8.5 8.1 0.51 10.5 4.7 1.7 2 0 0 2 2 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2722 PF10846.8 CDI86858.1 - 2.8 6.8 28.4 5.3 5.9 28.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Band_3_cyto PF07565.13 CDI86858.1 - 2.9 7.6 6.8 6.5 6.5 6.8 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Suf PF05843.14 CDI86858.1 - 3 7.8 15.1 6.9 6.6 15.1 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF1980 PF09323.10 CDI86858.1 - 3.6 7.5 4.3 7.7 6.4 4.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) eIF-3_zeta PF05091.12 CDI86858.1 - 4.6 6.1 11.4 7.8 5.3 11.4 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) VIT1 PF01988.19 CDI86858.1 - 4.8 7.0 6.9 27 4.6 2.9 2.3 2 0 0 2 2 2 0 VIT family RR_TM4-6 PF06459.12 CDI86858.1 - 5.1 6.9 8.7 12 5.6 8.7 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pex14_N PF04695.13 CDI86858.1 - 5.1 7.7 17.3 0.56 10.9 12.3 1.9 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region UPF0560 PF10577.9 CDI86858.1 - 5.5 5.4 14.1 11 4.4 14.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Ndc1_Nup PF09531.10 CDI86858.1 - 6 5.4 7.6 10 4.7 7.6 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Tim54 PF11711.8 CDI86858.1 - 6.4 5.4 8.1 10 4.7 8.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Neur_chan_memb PF02932.16 CDI86858.1 - 7 6.6 8.7 0.22 11.6 0.8 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region EIIBC-GUT_N PF03612.14 CDI86858.1 - 8.5 6.1 8.9 17 5.1 8.9 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4763 PF15960.5 CDI86860.1 - 0.015 14.6 3.5 0.015 14.6 3.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) TMF_DNA_bd PF12329.8 CDI86860.1 - 0.14 12.1 0.3 0.14 12.1 0.3 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Prefoldin PF02996.17 CDI86860.1 - 0.62 10.0 8.8 3 7.8 3.8 2.3 2 0 0 2 2 2 0 Prefoldin subunit DUF1043 PF06295.12 CDI86860.1 - 1.1 9.3 9.4 0.32 11.0 4.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) TFIIA PF03153.13 CDI86860.1 - 4.8 7.1 11.2 6.3 6.7 11.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI86861.1 - 8.2e-05 23.0 8.3 8.2e-05 23.0 8.3 7.8 1 1 5 6 6 6 2 Anti-sigma-K factor rskA GT87 PF09594.10 CDI86861.1 - 0.0076 16.0 22.4 0.23 11.2 16.3 3.5 3 1 0 3 3 3 2 Glycosyltransferase family 87 AAA_23 PF13476.6 CDI86862.1 - 0.088 13.3 17.6 0.11 13.0 17.6 1.1 1 0 0 1 1 1 0 AAA domain BSP_II PF05432.11 CDI86862.1 - 0.25 11.0 16.6 0.36 10.5 16.6 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) PAT1 PF09770.9 CDI86862.1 - 0.28 9.4 37.8 0.29 9.4 37.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Utp14 PF04615.13 CDI86862.1 - 0.74 8.3 32.1 0.93 8.0 32.1 1.2 1 0 0 1 1 1 0 Utp14 protein PPP4R2 PF09184.11 CDI86862.1 - 9.2 5.8 30.7 13 5.2 30.7 1.2 1 0 0 1 1 1 0 PPP4R2 Spt20 PF12090.8 CDI86863.1 - 0.00043 20.0 43.0 0.00085 19.0 10.1 12.4 8 4 4 12 12 12 3 Spt20 family DUF2722 PF10846.8 CDI86863.1 - 0.0037 16.3 6.8 0.0037 16.3 6.8 13.0 7 4 3 10 10 10 1 Protein of unknown function (DUF2722) DUF4813 PF16072.5 CDI86864.1 - 0.0042 16.8 29.0 0.006 16.3 29.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4813) Rib_recp_KP_reg PF05104.12 CDI86864.1 - 0.0063 17.6 13.1 0.0063 17.6 13.1 1.7 2 0 0 2 2 2 1 Ribosome receptor lysine/proline rich region FtsL PF04999.13 CDI86864.1 - 0.48 10.5 5.5 1 9.4 5.5 1.5 1 0 0 1 1 1 0 Cell division protein FtsL Utp14 PF04615.13 CDI86865.1 - 0.028 13.0 54.8 0.032 12.8 54.8 1.1 1 0 0 1 1 1 0 Utp14 protein SpoIIP PF07454.11 CDI86866.1 - 0.0088 15.5 12.8 0.0088 15.5 12.8 3.2 3 0 0 3 3 3 2 Stage II sporulation protein P (SpoIIP) SID-1_RNA_chan PF13965.6 CDI86866.1 - 0.035 12.5 19.7 0.022 13.2 9.0 2.3 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 SDA1 PF05285.12 CDI86866.1 - 0.082 12.3 26.9 0.23 10.9 10.4 2.2 2 0 0 2 2 2 0 SDA1 BORG_CEP PF14957.6 CDI86866.1 - 0.94 10.7 36.7 0.4 11.8 7.3 3.3 3 0 0 3 3 3 0 Cdc42 effector DUF4746 PF15928.5 CDI86866.1 - 1.3 8.4 16.5 0.46 9.9 9.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) EPL1 PF10513.9 CDI86866.1 - 1.9 8.9 44.8 0.42 11.0 17.1 3.2 3 0 0 3 3 3 0 Enhancer of polycomb-like Tmp39 PF10271.9 CDI86866.1 - 2.3 7.1 4.7 3.6 6.5 4.7 1.3 1 0 0 1 1 1 0 Putative transmembrane protein DUF2052 PF09747.9 CDI86866.1 - 3 7.9 26.8 1 9.5 12.7 3.0 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) BBL5 PF07289.11 CDI86866.1 - 3.8 6.5 17.5 0.24 10.4 9.4 2.3 2 0 0 2 2 2 0 Bardet-Biedl syndrome 5 protein RPN2_C PF18004.1 CDI86866.1 - 7.5 6.4 33.6 0.16 11.9 14.3 3.1 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN2 C-terminal domain CobT PF06213.12 CDI86866.1 - 8.4 5.7 47.8 1.5 8.1 24.9 3.4 3 0 0 3 3 3 0 Cobalamin biosynthesis protein CobT Scs3p PF10261.9 CDI86866.1 - 8.4 5.8 8.7 21 4.5 5.1 2.6 2 0 0 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM WD40 PF00400.32 CDI86867.1 - 6e-22 77.5 1.7 2.2e-09 37.8 0.3 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI86867.1 - 1.3e-10 41.4 0.0 6.3e-06 26.4 0.0 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 CDI86867.1 - 9.3e-06 26.1 0.0 1.5e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 CDI86867.1 - 0.063 12.2 0.0 0.53 9.2 0.0 2.0 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein GET2 PF08690.10 CDI86867.1 - 0.1 12.3 0.1 0.1 12.3 0.1 2.0 2 0 0 2 2 2 0 GET complex subunit GET2 eIF2A PF08662.11 CDI86867.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A DUF4667 PF15700.5 CDI86867.1 - 1.9 8.5 12.0 0.29 11.2 3.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) DAZAP2 PF11029.8 CDI86867.1 - 2.7 8.9 12.5 0.21 12.5 5.4 2.2 2 0 0 2 2 2 0 DAZ associated protein 2 (DAZAP2) Secretin_N_2 PF07655.13 CDI86867.1 - 5.4 7.6 14.2 4.7 7.8 6.1 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain PepSY_2 PF13670.6 CDI86867.1 - 6.2 6.9 19.2 3.1 7.9 4.2 2.6 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain SelP_N PF04592.14 CDI86868.1 - 0.045 13.1 30.3 0.055 12.9 30.3 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DcuA_DcuB PF03605.14 CDI86868.1 - 0.14 11.0 7.8 0.18 10.7 7.8 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter SID-1_RNA_chan PF13965.6 CDI86868.1 - 0.29 9.5 9.1 0.31 9.4 9.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI86868.1 - 0.38 9.6 14.2 0.4 9.5 14.2 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) MgsA_C PF12002.8 CDI86868.1 - 0.51 10.3 17.2 0.67 9.9 17.2 1.2 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal Macoilin PF09726.9 CDI86868.1 - 0.76 8.3 20.3 0.87 8.1 20.3 1.0 1 0 0 1 1 1 0 Macoilin family RR_TM4-6 PF06459.12 CDI86868.1 - 1 9.1 25.1 1.1 9.0 25.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paf1 PF03985.13 CDI86868.1 - 1.2 8.0 22.6 1.3 7.9 22.6 1.0 1 0 0 1 1 1 0 Paf1 eIF-3_zeta PF05091.12 CDI86868.1 - 1.6 7.6 27.3 1.9 7.4 27.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PPP4R2 PF09184.11 CDI86868.1 - 2 8.0 12.8 2.1 7.8 12.8 1.0 1 0 0 1 1 1 0 PPP4R2 CDC45 PF02724.14 CDI86868.1 - 2.1 6.6 17.1 2 6.6 17.1 1.1 1 0 0 1 1 1 0 CDC45-like protein BAF1_ABF1 PF04684.13 CDI86868.1 - 2.1 7.3 25.2 2.3 7.2 25.2 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor VIT1 PF01988.19 CDI86868.1 - 2.3 8.0 9.2 3.6 7.4 9.2 1.3 1 0 0 1 1 1 0 VIT family Gti1_Pac2 PF09729.9 CDI86868.1 - 2.4 8.2 19.0 2.6 8.1 19.0 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family IHABP4_N PF16174.5 CDI86868.1 - 2.6 8.6 32.1 3.1 8.4 32.1 1.1 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Pannexin_like PF12534.8 CDI86868.1 - 2.6 7.0 18.6 3.2 6.8 18.6 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 FAM60A PF15396.6 CDI86868.1 - 2.6 8.0 18.4 2.9 7.8 18.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A VIR_N PF15912.5 CDI86868.1 - 2.9 7.4 15.9 3.3 7.2 15.9 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal Peptidase_S49_N PF08496.10 CDI86868.1 - 3 7.9 16.7 4.6 7.3 16.7 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4228 PF14009.6 CDI86868.1 - 3.1 8.2 15.2 4.2 7.7 15.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Rtf2 PF04641.12 CDI86868.1 - 3.3 7.0 19.9 4.4 6.6 19.9 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger TFIIA PF03153.13 CDI86868.1 - 3.5 7.5 60.5 4.5 7.1 60.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RPN2_C PF18004.1 CDI86868.1 - 3.5 7.5 22.1 4.4 7.2 22.1 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain SpoIIP PF07454.11 CDI86868.1 - 3.7 6.9 23.2 4.6 6.6 23.2 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DDHD PF02862.17 CDI86868.1 - 4.1 7.5 22.4 6.1 6.9 22.4 1.3 1 0 0 1 1 1 0 DDHD domain Hamartin PF04388.12 CDI86868.1 - 5 5.7 24.5 5.8 5.5 24.5 1.0 1 0 0 1 1 1 0 Hamartin protein Neur_chan_memb PF02932.16 CDI86868.1 - 5.5 7.0 20.2 5.9 6.9 20.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 CDI86868.1 - 5.5 5.9 24.0 6.3 5.7 24.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 AF-4 PF05110.13 CDI86868.1 - 7.3 4.5 32.7 7.5 4.5 32.7 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein BORG_CEP PF14957.6 CDI86868.1 - 7.9 7.7 16.4 9.7 7.4 16.4 1.2 1 0 0 1 1 1 0 Cdc42 effector NPR3 PF03666.13 CDI86868.1 - 8.1 5.1 20.7 8.8 5.0 20.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PBP_sp32 PF07222.12 CDI86868.1 - 8.3 5.8 26.6 10 5.5 26.6 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF1387 PF07139.11 CDI86868.1 - 9 5.9 24.0 11 5.6 24.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) NicO PF03824.16 CDI86868.1 - 9.1 5.5 8.3 12 5.2 8.3 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein CLN3 PF02487.17 CDI86868.1 - 9.8 5.1 18.5 11 4.9 18.5 1.1 1 0 0 1 1 1 0 CLN3 protein SLC12 PF03522.15 CDI86869.1 - 0.057 12.4 34.7 0.094 11.7 34.7 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI86869.1 - 0.65 8.1 38.8 1.2 7.1 38.8 1.5 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CDI86869.1 - 2.5 5.1 49.6 3.2 4.8 49.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOBP PF15279.6 CDI86869.1 - 6.8 7.2 39.3 9.3 6.8 39.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF1772 PF08592.11 CDI86870.1 - 9.1e-05 22.8 2.4 0.00011 22.5 2.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) SprA-related PF12118.8 CDI86870.1 - 0.0042 16.3 42.8 0.0058 15.8 42.8 1.1 1 0 0 1 1 1 1 SprA-related family SARAF PF06682.12 CDI86870.1 - 0.015 15.0 16.8 0.02 14.6 16.8 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis BAF1_ABF1 PF04684.13 CDI86870.1 - 0.042 12.9 26.1 0.056 12.5 26.1 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SID-1_RNA_chan PF13965.6 CDI86870.1 - 0.075 11.4 7.2 0.089 11.2 7.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 O-antigen_lig PF13425.6 CDI86870.1 - 0.09 11.6 9.5 0.11 11.3 9.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein GAGA_bind PF06217.12 CDI86870.1 - 0.15 12.4 17.2 0.17 12.1 17.2 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family VIR_N PF15912.5 CDI86870.1 - 0.16 11.5 8.7 0.2 11.2 8.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal IgaA PF07095.11 CDI86870.1 - 0.17 9.8 8.7 0.23 9.4 8.7 1.1 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA CLN3 PF02487.17 CDI86870.1 - 0.2 10.6 11.9 0.27 10.3 11.9 1.2 1 0 0 1 1 1 0 CLN3 protein RR_TM4-6 PF06459.12 CDI86870.1 - 0.23 11.3 16.2 0.3 10.9 16.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 CDI86870.1 - 0.33 10.1 5.3 0.37 10.0 5.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter V_ATPase_I PF01496.19 CDI86870.1 - 0.61 7.9 19.8 0.67 7.8 19.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-3_zeta PF05091.12 CDI86870.1 - 0.62 9.0 21.4 0.76 8.7 21.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) OATP PF03137.20 CDI86870.1 - 0.67 8.2 5.5 1 7.5 5.5 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SLC12 PF03522.15 CDI86870.1 - 0.69 8.9 15.9 0.76 8.7 15.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Serinc PF03348.15 CDI86870.1 - 0.75 8.7 13.9 0.94 8.3 13.9 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Piezo_RRas_bdg PF12166.8 CDI86870.1 - 0.75 9.0 9.7 0.78 9.0 9.7 1.1 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain NEMP PF10225.9 CDI86870.1 - 0.88 9.2 8.3 1.3 8.6 8.3 1.2 1 0 0 1 1 1 0 NEMP family Hamartin PF04388.12 CDI86870.1 - 0.96 8.0 20.0 1.2 7.7 20.0 1.0 1 0 0 1 1 1 0 Hamartin protein Connexin PF00029.19 CDI86870.1 - 1.3 8.8 12.9 1.9 8.2 12.9 1.2 1 0 0 1 1 1 0 Connexin Trp_oprn_chp PF09534.10 CDI86870.1 - 1.5 8.6 27.6 2.5 7.9 27.4 1.5 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PAT1 PF09770.9 CDI86870.1 - 2 6.5 35.9 2.3 6.4 35.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Dynamin_N PF00350.23 CDI86870.1 - 2.8 8.0 10.5 4.5 7.3 10.5 1.3 1 0 0 1 1 1 0 Dynamin family CSG2 PF16965.5 CDI86870.1 - 2.8 6.8 9.1 3.2 6.6 9.1 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Hid1 PF12722.7 CDI86870.1 - 3.7 5.5 16.0 4 5.5 16.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AAA_23 PF13476.6 CDI86870.1 - 4.1 7.9 17.5 5 7.6 17.5 1.2 1 0 0 1 1 1 0 AAA domain MDM10 PF12519.8 CDI86870.1 - 4.5 6.0 12.7 5 5.9 12.7 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 GET2 PF08690.10 CDI86870.1 - 5.1 6.7 24.6 6.9 6.2 24.6 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 ETRAMP PF09716.10 CDI86870.1 - 5.8 7.1 6.1 12 6.0 6.1 1.9 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) HemX PF04375.14 CDI86870.1 - 6.3 6.0 40.3 9.3 5.4 40.3 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Lig_chan PF00060.26 CDI86870.1 - 8.1 6.3 14.1 11 5.8 14.1 1.4 1 1 0 1 1 1 0 Ligand-gated ion channel HCO3_cotransp PF00955.21 CDI86870.1 - 9.1 5.0 9.7 12 4.6 9.7 1.2 1 0 0 1 1 1 0 HCO3- transporter family LMBR1 PF04791.16 CDI86870.1 - 9.3 5.0 9.7 9 5.1 9.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein MAJIN PF15077.6 CDI86870.1 - 9.7 5.9 15.8 12 5.6 15.8 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Usp PF00582.26 CDI86871.1 - 0.04 14.4 3.3 0.064 13.8 3.3 1.3 1 0 0 1 1 1 0 Universal stress protein family BAF1_ABF1 PF04684.13 CDI86871.1 - 0.066 12.3 5.7 0.081 12.0 5.7 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Activator_LAG-3 PF11498.8 CDI86871.1 - 0.12 11.4 28.4 0.15 11.0 28.4 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Ribosomal_60s PF00428.19 CDI86871.1 - 0.5 11.0 11.6 0.066 13.8 6.9 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein TFIIA PF03153.13 CDI86871.1 - 0.55 10.2 27.2 0.7 9.8 27.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CDI86871.1 - 0.64 10.7 16.9 1 10.0 16.9 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region eIF-3_zeta PF05091.12 CDI86871.1 - 0.9 8.4 11.8 1.2 8.1 11.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI86871.1 - 2.7 6.7 8.3 3.1 6.5 8.3 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI86871.1 - 3.8 7.5 4.8 4.7 7.2 4.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Exonuc_VII_L PF02601.15 CDI86871.1 - 3.9 7.0 15.8 3.5 7.1 14.7 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit PAT1 PF09770.9 CDI86871.1 - 4.1 5.6 18.7 4.8 5.3 18.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FAM199X PF15814.5 CDI86871.1 - 4.7 6.2 7.8 8.6 5.3 7.8 1.5 1 0 0 1 1 1 0 Protein family FAM199X GREB1 PF15782.5 CDI86871.1 - 7.9 3.4 9.7 8.8 3.3 9.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MMR1 PF08505.10 CDI86874.1 - 0.0016 18.8 14.1 0.0021 18.4 14.1 1.1 1 0 0 1 1 1 1 Mitochondrial Myo2 receptor-related protein SDA1 PF05285.12 CDI86874.1 - 0.0022 17.5 9.3 0.0024 17.4 9.3 1.1 1 0 0 1 1 1 1 SDA1 TFIIA PF03153.13 CDI86874.1 - 0.0022 18.1 25.7 0.0027 17.8 25.7 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI86874.1 - 0.0039 16.8 10.1 0.0054 16.4 10.1 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein SpoIIP PF07454.11 CDI86874.1 - 0.0086 15.6 6.2 0.01 15.3 6.2 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Spt20 PF12090.8 CDI86874.1 - 0.011 15.4 28.4 0.015 15.0 28.4 1.2 1 0 0 1 1 1 0 Spt20 family RR_TM4-6 PF06459.12 CDI86874.1 - 0.025 14.4 12.5 0.031 14.1 12.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 CDI86874.1 - 0.037 14.1 4.6 0.039 14.0 4.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CNDH2_C PF16858.5 CDI86874.1 - 0.053 13.4 9.5 0.066 13.1 9.5 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term EPL1 PF10513.9 CDI86874.1 - 0.054 13.9 9.0 0.085 13.2 9.0 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like CDC45 PF02724.14 CDI86874.1 - 0.065 11.5 12.1 0.078 11.3 12.1 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF908 PF06012.12 CDI86874.1 - 0.08 12.3 9.8 0.094 12.1 9.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Lin-8 PF03353.15 CDI86874.1 - 0.094 12.3 13.9 0.12 11.9 13.9 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2722 PF10846.8 CDI86874.1 - 0.097 11.6 21.8 0.13 11.2 21.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Draxin PF15550.6 CDI86874.1 - 0.21 11.5 7.2 0.26 11.1 7.2 1.1 1 0 0 1 1 1 0 Draxin Activator_LAG-3 PF11498.8 CDI86874.1 - 0.23 10.4 25.7 0.28 10.1 25.7 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Macoilin PF09726.9 CDI86874.1 - 0.24 9.9 11.5 0.3 9.6 11.5 1.0 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 CDI86874.1 - 0.25 8.4 11.9 0.3 8.2 11.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Utp14 PF04615.13 CDI86874.1 - 0.27 9.7 17.6 0.34 9.4 17.6 1.0 1 0 0 1 1 1 0 Utp14 protein Mitofilin PF09731.9 CDI86874.1 - 0.29 9.9 20.3 0.36 9.6 20.3 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein NST1 PF13945.6 CDI86874.1 - 0.3 11.2 20.3 0.42 10.7 20.3 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator FAM176 PF14851.6 CDI86874.1 - 0.36 10.5 8.2 0.52 10.0 8.2 1.2 1 0 0 1 1 1 0 FAM176 family DUF702 PF05142.12 CDI86874.1 - 0.38 11.2 11.3 0.58 10.6 11.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Sporozoite_P67 PF05642.11 CDI86874.1 - 0.4 8.7 10.0 0.49 8.4 10.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4647 PF15504.6 CDI86874.1 - 0.49 9.4 11.4 0.66 9.0 11.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DUF913 PF06025.12 CDI86874.1 - 0.72 8.8 6.3 0.83 8.6 6.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Dfp1_Him1_M PF08630.10 CDI86874.1 - 0.75 10.0 6.9 43 4.3 0.0 2.2 2 0 0 2 2 2 0 Dfp1/Him1, central region Menin PF05053.13 CDI86874.1 - 0.78 8.0 9.9 1 7.7 9.9 1.2 1 0 0 1 1 1 0 Menin BAF1_ABF1 PF04684.13 CDI86874.1 - 0.79 8.7 14.6 0.95 8.4 14.6 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Chorion_2 PF03964.15 CDI86874.1 - 0.89 10.4 19.5 1.6 9.6 19.3 1.5 1 1 0 1 1 1 0 Chorion family 2 Apt1 PF10351.9 CDI86874.1 - 0.97 8.2 12.3 1.3 7.8 12.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4746 PF15928.5 CDI86874.1 - 0.99 8.8 7.9 1.2 8.4 7.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SpoIIE PF07228.12 CDI86874.1 - 1 9.2 3.5 0.29 11.0 0.2 1.7 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) SOG2 PF10428.9 CDI86874.1 - 1.2 8.2 12.7 1.5 7.9 12.7 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Rrn6 PF10214.9 CDI86874.1 - 1.5 7.2 15.4 1.8 7.0 15.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF2052 PF09747.9 CDI86874.1 - 1.7 8.7 16.2 2.6 8.1 16.2 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) UPF0560 PF10577.9 CDI86874.1 - 2 6.8 17.9 2.5 6.5 17.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Ndc1_Nup PF09531.10 CDI86874.1 - 2 7.0 14.2 2.6 6.6 14.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Paf1 PF03985.13 CDI86874.1 - 2.3 7.1 19.0 3.2 6.6 19.0 1.1 1 0 0 1 1 1 0 Paf1 Band_3_cyto PF07565.13 CDI86874.1 - 2.4 7.9 9.5 3.2 7.5 9.5 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4175 PF13779.6 CDI86874.1 - 3 5.7 28.7 3.7 5.3 28.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4770 PF15994.5 CDI86874.1 - 3.1 8.0 10.7 5.4 7.2 10.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Connexin PF00029.19 CDI86874.1 - 3.1 7.5 7.7 4.1 7.1 7.7 1.2 1 0 0 1 1 1 0 Connexin Dicty_REP PF05086.12 CDI86874.1 - 3.3 5.6 5.7 3.6 5.4 5.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SRP-alpha_N PF04086.13 CDI86874.1 - 3.5 7.5 17.8 4.6 7.1 17.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF4554 PF15091.6 CDI86874.1 - 4.1 6.2 13.0 5.1 5.9 13.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Plasmodium_Vir PF05795.11 CDI86874.1 - 4.3 6.6 11.1 5.5 6.3 11.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PIG-S PF10510.9 CDI86874.1 - 4.6 6.0 10.4 5.8 5.6 10.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Coilin_N PF15862.5 CDI86874.1 - 4.8 7.0 14.7 10 5.9 14.7 1.5 1 0 0 1 1 1 0 Coilin N-terminus Peptidase_S64 PF08192.11 CDI86874.1 - 5 5.5 12.5 6.1 5.2 12.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 PAT1 PF09770.9 CDI86874.1 - 5.3 5.2 20.0 6.5 4.9 20.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CPSF100_C PF13299.6 CDI86874.1 - 5.4 7.2 12.4 8.2 6.6 12.4 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Sec62 PF03839.16 CDI86874.1 - 6.3 6.2 6.3 8.2 5.9 6.3 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 ALMT PF11744.8 CDI86874.1 - 7.3 5.3 10.7 9.1 5.0 10.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 CDI86874.1 - 8.1 5.4 13.7 10 5.0 13.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CLN3 PF02487.17 CDI86874.1 - 8.3 5.3 7.5 10 5.0 7.5 1.2 1 0 0 1 1 1 0 CLN3 protein DUF3487 PF11990.8 CDI86875.1 - 0.044 13.7 0.1 0.044 13.7 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) NTP_transf_3 PF12804.7 CDI86875.1 - 0.37 11.1 4.9 0.28 11.5 3.3 1.6 2 0 0 2 2 2 0 MobA-like NTP transferase domain DUF726 PF05277.12 CDI86875.1 - 2 7.3 6.6 2.8 6.8 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) RRM_1 PF00076.22 CDI86876.1 - 8.9e-10 38.3 0.1 1e-05 25.3 0.0 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI86876.1 - 0.013 15.6 0.0 0.013 15.6 0.0 2.6 3 2 1 4 4 4 0 RNA recognition motif SPX PF03105.19 CDI86876.1 - 0.25 11.2 17.0 0.3 11.0 17.0 1.1 1 0 0 1 1 1 0 SPX domain UDPG_MGDP_dh_C PF03720.15 CDI86876.1 - 0.92 10.0 4.8 17 5.9 0.8 2.4 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PAT1 PF09770.9 CDI86876.1 - 1.6 6.9 36.7 1.9 6.6 36.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 CDI86876.1 - 2.3 7.2 18.6 3.2 6.7 18.6 1.3 1 0 0 1 1 1 0 Solute carrier family 12 SAPS PF04499.15 CDI86876.1 - 3 6.5 16.1 3.4 6.3 16.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ndc1_Nup PF09531.10 CDI86876.1 - 3.1 6.4 17.6 3.7 6.1 17.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ATP-sulfurylase PF01747.17 CDI86877.1 - 4e-89 297.7 0.0 5.4e-89 297.2 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 CDI86877.1 - 6.3e-52 175.6 0.0 1.6e-51 174.4 0.0 1.7 1 1 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 CDI86877.1 - 4.9e-31 107.5 0.0 4.1e-30 104.5 0.0 2.1 1 1 0 1 1 1 1 PUA-like domain AAA_33 PF13671.6 CDI86877.1 - 4.5e-07 30.1 0.0 1.8e-06 28.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 CDI86877.1 - 8.9e-05 22.1 0.0 0.00018 21.1 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_28 PF13521.6 CDI86877.1 - 0.0013 19.0 0.0 0.0027 18.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDI86877.1 - 0.0082 16.5 0.0 0.022 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 CDI86877.1 - 0.011 16.2 0.0 0.022 15.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CDI86877.1 - 0.072 12.4 0.0 0.24 10.6 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin MeaB PF03308.16 CDI86877.1 - 0.1 11.6 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 CDI86877.1 - 0.12 12.5 0.0 0.33 11.0 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase CLP1_P PF16575.5 CDI86877.1 - 0.14 12.0 0.0 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_29 PF13555.6 CDI86877.1 - 0.16 11.7 0.0 0.57 10.0 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain CIAPIN1 PF05093.13 CDI86878.1 - 1.2e-20 73.9 14.8 2.3e-17 63.3 3.3 2.3 1 1 1 2 2 2 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis K_channel_TID PF07941.11 CDI86878.1 - 0.0074 16.7 25.2 0.2 12.1 9.7 2.6 2 0 0 2 2 2 2 Potassium channel Kv1.4 tandem inactivation domain SR-25 PF10500.9 CDI86879.1 - 0.00024 20.8 11.2 0.00035 20.2 11.2 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Rab_eff_C PF04698.12 CDI86879.1 - 0.0052 15.2 4.1 0.0066 14.8 4.1 1.1 1 0 0 1 1 1 1 Rab effector MyRIP/melanophilin C-terminus PAP1 PF08601.10 CDI86879.1 - 0.033 13.9 7.1 0.04 13.6 7.1 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Macoilin PF09726.9 CDI86879.1 - 0.15 10.6 4.9 0.25 9.9 4.9 1.4 1 0 0 1 1 1 0 Macoilin family DUF2151 PF10221.9 CDI86879.1 - 0.16 10.6 0.7 0.2 10.2 0.7 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator EBP50_C PF09007.11 CDI86879.1 - 0.35 11.9 8.8 0.61 11.1 8.8 1.4 1 0 0 1 1 1 0 EBP50, C-terminal TFIIA PF03153.13 CDI86879.1 - 0.47 10.4 8.9 0.62 10.0 8.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NPR3 PF03666.13 CDI86879.1 - 0.52 9.0 4.8 0.72 8.6 4.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Bul1_N PF04425.12 CDI86879.1 - 0.58 8.9 4.3 0.86 8.3 4.3 1.2 1 0 0 1 1 1 0 Bul1 N terminus DUF1635 PF07795.11 CDI86879.1 - 0.62 9.9 9.7 1.7 8.4 8.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DUF4692 PF15763.5 CDI86879.1 - 1.1 9.8 7.3 2.1 8.8 7.3 1.5 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) AF-4 PF05110.13 CDI86879.1 - 1.4 6.9 17.2 1.9 6.5 17.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CCDC106 PF15794.5 CDI86879.1 - 1.6 8.4 8.9 2.3 7.9 8.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Presenilin PF01080.17 CDI86879.1 - 4.4 6.0 6.7 6.9 5.3 6.7 1.3 1 0 0 1 1 1 0 Presenilin RAB3GAP2_N PF14655.6 CDI86881.1 - 0.02 14.2 8.5 0.022 14.0 8.5 1.0 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF3177 PF11375.8 CDI86881.1 - 0.084 12.6 0.8 0.086 12.6 0.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3177) NAD_binding_9 PF13454.6 CDI86881.1 - 0.29 11.1 3.9 0.34 10.9 3.9 1.1 1 0 0 1 1 1 0 FAD-NAD(P)-binding DUF1151 PF06625.11 CDI86881.1 - 0.35 10.8 18.0 0.44 10.5 18.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) PigN PF04987.14 CDI86881.1 - 0.7 8.7 5.2 0.81 8.5 5.2 1.0 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Tegument_dsDNA PF12818.7 CDI86881.1 - 1.1 8.3 7.3 1.4 8.0 7.3 1.0 1 0 0 1 1 1 0 dsDNA viral tegument protein Velvet PF11754.8 CDI86882.1 - 0.0013 18.7 3.1 0.0016 18.4 3.1 1.1 1 0 0 1 1 1 1 Velvet factor PPL5 PF18168.1 CDI86882.1 - 0.0037 16.6 6.8 0.0048 16.3 6.8 1.1 1 0 0 1 1 1 1 Prim-pol family 5 SID-1_RNA_chan PF13965.6 CDI86882.1 - 0.0044 15.5 0.1 0.0044 15.5 0.1 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 CLN3 PF02487.17 CDI86882.1 - 0.0064 15.6 7.6 0.008 15.3 7.6 1.1 1 0 0 1 1 1 1 CLN3 protein TFIIA PF03153.13 CDI86882.1 - 0.0083 16.2 25.5 0.0094 16.0 25.5 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2052 PF09747.9 CDI86882.1 - 0.011 15.9 12.0 0.013 15.6 12.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF1943 PF09172.11 CDI86882.1 - 0.015 14.6 1.5 0.017 14.4 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) DUF5327 PF17261.2 CDI86882.1 - 0.016 15.9 13.9 0.021 15.6 13.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5327) Presenilin PF01080.17 CDI86882.1 - 0.018 13.8 12.5 0.023 13.5 12.5 1.2 1 0 0 1 1 1 0 Presenilin CobT PF06213.12 CDI86882.1 - 0.023 14.1 18.3 0.029 13.8 18.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Connexin PF00029.19 CDI86882.1 - 0.029 14.1 9.7 0.037 13.8 9.7 1.2 1 0 0 1 1 1 0 Connexin Neur_chan_memb PF02932.16 CDI86882.1 - 0.031 14.3 4.8 0.039 14.0 4.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region V_ATPase_I PF01496.19 CDI86882.1 - 0.031 12.2 12.8 0.036 12.0 12.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DcuA_DcuB PF03605.14 CDI86882.1 - 0.032 13.1 1.0 0.039 12.9 1.0 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DDHD PF02862.17 CDI86882.1 - 0.041 14.0 9.6 0.048 13.8 9.6 1.1 1 0 0 1 1 1 0 DDHD domain EIIBC-GUT_N PF03612.14 CDI86882.1 - 0.042 13.6 7.8 0.06 13.1 7.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3984 PF13136.6 CDI86882.1 - 0.045 13.2 10.0 0.055 12.9 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) SpoIIP PF07454.11 CDI86882.1 - 0.068 12.6 13.2 0.086 12.3 13.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TERB2 PF15101.6 CDI86882.1 - 0.071 13.2 14.9 0.083 12.9 14.9 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TRAP_alpha PF03896.16 CDI86882.1 - 0.075 12.2 6.3 0.12 11.6 6.3 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PBP_sp32 PF07222.12 CDI86882.1 - 0.084 12.3 17.0 0.11 11.9 17.0 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 CCDC53 PF10152.9 CDI86882.1 - 0.087 13.2 12.2 0.11 12.9 12.2 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex RskA PF10099.9 CDI86882.1 - 0.098 12.9 8.8 0.14 12.5 7.8 1.7 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Paf1 PF03985.13 CDI86882.1 - 0.1 11.6 16.1 0.12 11.3 16.1 1.1 1 0 0 1 1 1 0 Paf1 DUF4175 PF13779.6 CDI86882.1 - 0.11 10.4 26.1 0.12 10.3 26.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) eIF-3_zeta PF05091.12 CDI86882.1 - 0.11 11.5 13.3 0.12 11.3 13.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Afi1 PF07792.12 CDI86882.1 - 0.13 12.8 11.9 0.16 12.5 11.9 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PIP5K PF01504.18 CDI86882.1 - 0.13 11.5 11.1 0.15 11.2 11.1 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase FAM176 PF14851.6 CDI86882.1 - 0.13 11.9 6.9 0.19 11.4 6.9 1.3 1 0 0 1 1 1 0 FAM176 family RR_TM4-6 PF06459.12 CDI86882.1 - 0.13 12.1 12.2 0.15 11.8 12.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AIF_C PF14721.6 CDI86882.1 - 0.14 12.5 9.9 0.22 11.9 9.9 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF913 PF06025.12 CDI86882.1 - 0.15 11.0 5.7 0.16 10.9 5.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SprA-related PF12118.8 CDI86882.1 - 0.15 11.2 21.6 0.18 10.9 21.6 1.2 1 0 0 1 1 1 0 SprA-related family CSG2 PF16965.5 CDI86882.1 - 0.17 10.8 4.2 0.21 10.5 4.2 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Peptidase_S49_N PF08496.10 CDI86882.1 - 0.19 11.8 9.9 0.26 11.4 9.9 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Spt20 PF12090.8 CDI86882.1 - 0.24 11.0 35.8 0.33 10.5 35.8 1.1 1 0 0 1 1 1 0 Spt20 family Coilin_N PF15862.5 CDI86882.1 - 0.27 11.0 14.5 0.38 10.6 14.5 1.2 1 0 0 1 1 1 0 Coilin N-terminus CPSF100_C PF13299.6 CDI86882.1 - 0.28 11.3 10.2 0.35 11.0 10.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal MMR1 PF08505.10 CDI86882.1 - 0.32 11.3 15.0 0.38 11.0 15.0 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein U3_snoRNA_assoc PF08297.11 CDI86882.1 - 0.36 11.6 10.7 0.66 10.7 10.7 1.4 1 0 0 1 1 1 0 U3 snoRNA associated DUF2828 PF11443.8 CDI86882.1 - 0.45 8.5 12.7 0.58 8.2 12.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SLC12 PF03522.15 CDI86882.1 - 0.48 9.4 11.6 0.54 9.2 11.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Serinc PF03348.15 CDI86882.1 - 0.61 9.0 9.8 0.022 13.7 4.3 1.4 2 0 0 2 2 1 0 Serine incorporator (Serinc) Tim54 PF11711.8 CDI86882.1 - 0.68 8.6 13.8 0.91 8.2 13.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 UPF0239 PF06783.11 CDI86882.1 - 0.7 10.1 8.0 1.3 9.2 8.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) DUF1980 PF09323.10 CDI86882.1 - 0.73 9.7 9.9 1.4 8.8 9.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) Activator_LAG-3 PF11498.8 CDI86882.1 - 0.8 8.6 34.9 0.98 8.3 34.9 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 EOS1 PF12326.8 CDI86882.1 - 0.86 9.5 4.9 1.2 9.0 4.9 1.3 1 0 0 1 1 1 0 N-glycosylation protein DUF4746 PF15928.5 CDI86882.1 - 0.89 8.9 12.5 1.2 8.5 12.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FAM60A PF15396.6 CDI86882.1 - 0.93 9.5 7.7 1.1 9.2 7.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A TMEM51 PF15345.6 CDI86882.1 - 1.2 9.0 16.5 2.2 8.0 16.5 1.5 1 1 0 1 1 1 0 Transmembrane protein 51 Peptidase_S15 PF02129.18 CDI86882.1 - 1.2 8.6 8.1 1.6 8.2 8.1 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) YABBY PF04690.13 CDI86882.1 - 1.5 9.4 9.6 1.9 9.0 9.6 1.2 1 0 0 1 1 1 0 YABBY protein Folate_carrier PF01770.18 CDI86882.1 - 1.6 7.4 5.3 1.9 7.1 5.3 1.2 1 0 0 1 1 1 0 Reduced folate carrier Scs3p PF10261.9 CDI86882.1 - 2.4 7.6 4.8 3.8 6.9 4.8 1.3 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Ureide_permease PF07168.11 CDI86882.1 - 2.8 6.6 6.5 3.7 6.2 6.5 1.1 1 0 0 1 1 1 0 Ureide permease Band_3_cyto PF07565.13 CDI86882.1 - 2.9 7.6 13.6 3.7 7.3 13.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain ALMT PF11744.8 CDI86882.1 - 4.3 6.1 11.0 5 5.8 11.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Gti1_Pac2 PF09729.9 CDI86882.1 - 5.3 7.1 11.1 7.3 6.6 11.1 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Paramyxo_ncap PF00973.19 CDI86882.1 - 6.8 5.5 8.8 7.6 5.3 8.8 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Membralin PF09746.9 CDI86882.1 - 7.2 5.5 9.4 9.5 5.1 9.4 1.1 1 0 0 1 1 1 0 Tumour-associated protein Eapp_C PF10238.9 CDI86882.1 - 7.5 6.6 17.5 10 6.2 17.5 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein Asparaginase_2 PF01112.18 CDI86882.1 - 8.6 5.3 7.9 10 5.0 7.9 1.2 1 0 0 1 1 1 0 Asparaginase Phostensin_N PF13916.6 CDI86884.1 - 2.4 8.6 16.7 0.3 11.4 2.7 2.8 1 1 1 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal TFIIA PF03153.13 CDI86885.1 - 0.039 13.9 27.2 0.048 13.6 27.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MCM_bind PF09739.9 CDI86885.1 - 0.38 9.1 13.9 0.47 8.8 13.9 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor eIF-3_zeta PF05091.12 CDI86885.1 - 0.63 8.9 10.9 0.71 8.8 10.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Hamartin PF04388.12 CDI86885.1 - 3.5 6.2 17.6 4.4 5.8 17.6 1.1 1 0 0 1 1 1 0 Hamartin protein PIP5K PF01504.18 CDI86886.1 - 0.0051 16.1 1.6 0.0051 16.1 1.6 9.1 4 2 1 5 5 5 1 Phosphatidylinositol-4-phosphate 5-Kinase SUIM_assoc PF16619.5 CDI86887.1 - 0.021 14.9 3.7 0.021 14.9 3.7 4.9 4 1 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 DUF4710 PF15828.5 CDI86887.1 - 0.31 11.2 0.1 0.31 11.2 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4710) Maf1 PF09174.10 CDI86887.1 - 0.79 9.9 6.2 11 6.1 0.2 2.9 3 0 0 3 3 3 0 Maf1 regulator Ribosomal_60s PF00428.19 CDI86887.1 - 1.9 9.2 9.2 0.078 13.6 3.0 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein BORG_CEP PF14957.6 CDI86887.1 - 4.3 8.5 8.2 2.4 9.4 0.3 3.0 3 0 0 3 3 3 0 Cdc42 effector Suf PF05843.14 CDI86887.1 - 7.5 6.4 15.8 13 5.7 2.9 3.2 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) Utp14 PF04615.13 CDI86888.1 - 1.2 7.7 19.3 0.052 12.1 13.1 1.7 2 0 0 2 2 2 0 Utp14 protein DUF4228 PF14009.6 CDI86888.1 - 3.7 7.9 19.9 0.82 10.0 6.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4228) DUF2722 PF10846.8 CDI86889.1 - 0.001 18.2 38.8 0.071 12.0 21.5 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) SprA-related PF12118.8 CDI86889.1 - 0.0026 17.0 21.5 0.0026 17.0 21.5 5.3 3 1 1 4 4 2 1 SprA-related family RskA PF10099.9 CDI86889.1 - 0.0042 17.4 10.8 0.0042 17.4 10.8 8.1 3 3 4 7 7 4 2 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI86889.1 - 0.0071 15.4 18.7 0.02 13.9 5.6 2.1 2 0 0 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) HNOBA PF07701.14 CDI86889.1 - 0.0097 15.4 3.7 0.55 9.6 2.5 2.4 2 0 0 2 2 2 1 Heme NO binding associated Spt20 PF12090.8 CDI86889.1 - 0.065 12.8 53.7 0.23 11.1 14.2 2.7 2 0 0 2 2 2 0 Spt20 family DUF4207 PF13904.6 CDI86889.1 - 0.066 12.9 28.9 0.074 12.7 9.6 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) MAT1 PF06391.13 CDI86889.1 - 0.072 12.9 19.6 0.99 9.2 3.2 2.4 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 DUF4647 PF15504.6 CDI86889.1 - 0.15 11.2 21.8 0.018 14.2 10.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) Nha1_C PF08619.10 CDI86889.1 - 0.31 10.2 23.8 0.71 9.0 7.7 3.4 3 0 0 3 3 3 0 Alkali metal cation/H+ antiporter Nha1 C terminus EIF4E-T PF10477.9 CDI86889.1 - 0.52 9.1 22.7 1.1 8.0 11.4 2.2 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E UPF0524 PF15823.5 CDI86889.1 - 0.72 9.2 10.3 1.1 8.6 5.9 2.5 2 0 0 2 2 2 0 UPF0524 of C3orf70 EOS1 PF12326.8 CDI86889.1 - 1.2 9.1 8.5 2.7 7.9 2.3 2.5 2 0 0 2 2 2 0 N-glycosylation protein MPM1 PF17234.2 CDI86889.1 - 1.5 9.0 19.6 5.3 7.3 1.1 2.4 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 RIC3 PF15361.6 CDI86889.1 - 1.7 9.1 9.5 18 5.7 3.9 3.0 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 Connexin PF00029.19 CDI86889.1 - 2 8.1 11.3 1.8 8.3 5.4 2.3 2 0 0 2 2 2 0 Connexin MMR1 PF08505.10 CDI86889.1 - 2.9 8.1 31.6 0.05 13.9 10.0 3.2 3 0 0 3 3 3 0 Mitochondrial Myo2 receptor-related protein FAM60A PF15396.6 CDI86889.1 - 3.1 7.8 14.1 3.4 7.6 5.8 2.5 2 0 0 2 2 2 0 Protein Family FAM60A FAM76 PF16046.5 CDI86889.1 - 3.7 6.8 20.8 0.55 9.5 10.4 2.3 2 0 0 2 2 2 0 FAM76 protein AAA_23 PF13476.6 CDI86889.1 - 3.8 8.0 15.8 0.51 10.8 3.0 2.2 2 0 0 2 2 2 0 AAA domain DUF4770 PF15994.5 CDI86889.1 - 4.8 7.4 19.2 0.75 10.0 7.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) SID-1_RNA_chan PF13965.6 CDI86889.1 - 6.7 5.0 7.3 1.3 7.3 1.7 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Apt1 PF10351.9 CDI86889.1 - 6.8 5.4 12.7 3.2 6.5 5.6 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain PAT1 PF09770.9 CDI86889.1 - 7.2 4.7 40.8 0.46 8.7 13.6 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Ephrin_rec_like PF07699.13 CDI86890.1 - 0.22 11.3 1.1 0.55 10.0 1.1 1.6 1 0 0 1 1 1 0 Putative ephrin-receptor like PRA1 PF03208.19 CDI86891.1 - 1.5 8.4 6.3 2.6 7.6 6.3 1.4 1 0 0 1 1 1 0 PRA1 family protein Peptidase_M20 PF01546.28 CDI86892.1 - 1.1e-15 57.9 0.1 9.6e-07 28.7 0.0 3.3 3 0 0 3 3 3 2 Peptidase family M20/M25/M40 WD40 PF00400.32 CDI86892.1 - 9.5e-07 29.4 14.4 0.11 13.4 0.3 6.1 5 1 0 5 5 5 3 WD domain, G-beta repeat GATase_6 PF13522.6 CDI86892.1 - 0.00014 22.1 0.0 0.0019 18.4 0.0 2.6 2 1 1 3 3 3 1 Glutamine amidotransferase domain M20_dimer PF07687.14 CDI86892.1 - 0.00051 19.9 0.0 0.0014 18.5 0.0 1.8 1 0 0 1 1 1 1 Peptidase dimerisation domain GATase_4 PF13230.6 CDI86892.1 - 0.0056 15.6 0.2 0.049 12.5 0.0 2.4 3 0 0 3 3 3 1 Glutamine amidotransferases class-II CKS PF01111.19 CDI86893.1 - 3.7e-21 75.2 0.0 9.1e-21 73.9 0.0 1.7 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit ASFV_J13L PF05568.11 CDI86893.1 - 1.4 8.7 6.2 3.7 7.3 6.2 1.7 1 0 0 1 1 1 0 African swine fever virus J13L protein CutC PF03932.14 CDI86895.1 - 0.032 13.7 0.0 0.055 12.9 0.0 1.3 1 0 0 1 1 1 0 CutC family HigB-like_toxin PF05015.13 CDI86895.1 - 0.058 13.8 0.3 0.17 12.3 0.3 1.8 1 0 0 1 1 1 0 RelE-like toxin of type II toxin-antitoxin system HigB Peptidase_S68 PF10461.9 CDI86895.1 - 0.78 10.0 3.4 15 5.9 0.3 2.7 2 0 0 2 2 2 0 Peptidase S68 ACDC PF14733.6 CDI86896.1 - 2.7e-05 24.4 0.1 0.002 18.4 0.1 2.6 2 0 0 2 2 2 2 AP2-coincident C-terminal SUIM_assoc PF16619.5 CDI86897.1 - 0.00065 19.7 1.6 0.00065 19.7 1.6 23.2 15 6 5 20 20 20 6 Unstructured region C-term to UIM in Ataxin3 Gaa1 PF04114.14 CDI86898.1 - 0.077 12.0 2.9 0.11 11.5 2.9 1.2 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component Trypan_PARP PF05887.11 CDI86898.1 - 1.7 8.6 13.9 3.3 7.7 12.7 2.1 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Trypan_PARP PF05887.11 CDI86900.1 - 0.89 9.5 69.6 6.5 6.7 25.9 3.1 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) ATP12 PF07542.11 CDI86901.1 - 0.00017 21.6 10.4 0.00017 21.6 10.4 3.8 2 2 1 3 3 3 1 ATP12 chaperone protein AAA_23 PF13476.6 CDI86901.1 - 0.22 12.0 22.5 1.1 9.7 13.3 2.2 2 0 0 2 2 2 0 AAA domain Tau95_N PF17682.1 CDI86901.1 - 0.34 11.1 8.4 0.077 13.2 1.0 2.5 2 0 0 2 2 2 0 Tau95 Triple barrel domain TFIIA PF03153.13 CDI86901.1 - 0.88 9.5 80.9 0.23 11.4 44.1 2.1 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI86902.1 - 3.2e-07 30.2 28.3 8.3e-06 25.6 27.0 2.3 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI86902.1 - 0.0003 21.1 0.1 0.0003 21.1 0.1 3.4 1 1 0 2 2 1 1 Anti-sigma-K factor rskA DUF2828 PF11443.8 CDI86902.1 - 0.002 16.3 12.4 0.002 16.3 12.4 2.8 2 1 1 3 3 3 1 Domain of unknown function (DUF2828) SAPS PF04499.15 CDI86902.1 - 0.0023 16.8 18.1 0.0036 16.2 18.1 1.3 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein OmpH PF03938.14 CDI86902.1 - 0.0027 18.0 1.5 0.0027 18.0 1.5 2.6 2 1 0 2 2 1 1 Outer membrane protein (OmpH-like) RR_TM4-6 PF06459.12 CDI86902.1 - 0.0052 16.7 30.2 0.016 15.0 25.2 2.1 2 0 0 2 2 2 1 Ryanodine Receptor TM 4-6 DUF4667 PF15700.5 CDI86902.1 - 0.0074 16.4 24.3 0.0074 16.4 24.3 2.3 1 1 1 2 2 1 1 Domain of unknown function (DUF4667) CCSAP PF15748.5 CDI86902.1 - 0.019 15.1 45.9 0.13 12.4 41.0 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DUF4834 PF16118.5 CDI86902.1 - 0.13 13.3 0.2 0.13 13.3 0.2 3.7 2 1 0 2 2 1 0 Domain of unknown function (DUF4834) DUF92 PF01940.16 CDI86902.1 - 0.23 10.8 0.0 0.23 10.8 0.0 2.1 2 1 0 2 2 1 0 Integral membrane protein DUF92 CDC45 PF02724.14 CDI86902.1 - 0.35 9.1 31.2 2.3 6.4 29.1 2.0 2 0 0 2 2 2 0 CDC45-like protein DUF4045 PF13254.6 CDI86902.1 - 0.39 10.3 33.4 3.3 7.3 30.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) TCP PF03634.13 CDI86902.1 - 0.86 10.1 44.1 5.5 7.5 38.5 2.2 2 0 0 2 2 2 0 TCP family transcription factor DUF3807 PF12720.7 CDI86902.1 - 0.9 9.8 44.4 4.7 7.4 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) DUF5427 PF10310.9 CDI86902.1 - 1 8.3 36.6 11 4.8 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5427) DUF966 PF06136.13 CDI86902.1 - 1.2 8.8 33.2 4.8 6.8 28.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF966) DUF4569 PF15133.6 CDI86902.1 - 7.6 6.2 40.2 0.95 9.1 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4569) RskA PF10099.9 CDI86903.1 - 3.9e-06 27.3 4.5 3.9e-06 27.3 4.5 6.1 3 2 2 5 5 5 2 Anti-sigma-K factor rskA NAM-associated PF14303.6 CDI86903.1 - 0.00014 22.7 0.0 0.00014 22.7 0.0 6.8 4 3 2 7 7 7 1 No apical meristem-associated C-terminal domain DUF5308 PF17233.2 CDI86903.1 - 0.0025 18.1 0.5 0.0025 18.1 0.5 8.2 3 2 3 6 6 6 1 Family of unknown function (DUF5308) NifU PF01106.17 CDI86905.1 - 1.7e-12 47.3 0.1 8.7e-09 35.4 0.0 2.6 2 1 0 2 2 2 2 NifU-like domain Ad_Cy_reg PF16701.5 CDI86905.1 - 0.01 15.6 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase regulatory domain NESP55 PF06390.12 CDI86905.1 - 3.9 7.0 13.8 0.36 10.4 8.8 1.7 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) DUF1645 PF07816.11 CDI86908.1 - 0.0036 17.9 44.5 0.18 12.3 14.1 3.5 3 0 0 3 3 3 3 Protein of unknown function (DUF1645) Presenilin PF01080.17 CDI86908.1 - 0.0039 16.0 9.6 0.0039 16.0 9.6 2.4 2 1 0 2 2 2 1 Presenilin S4 PF01479.25 CDI86908.1 - 0.0042 16.8 0.0 0.0095 15.6 0.0 1.6 1 0 0 1 1 1 1 S4 domain MDM1 PF15501.6 CDI86908.1 - 0.0051 16.0 18.1 0.0051 16.0 18.1 3.1 3 0 0 3 3 3 1 Nuclear protein MDM1 Endostatin PF06482.11 CDI86908.1 - 0.036 13.5 25.8 0.05 13.1 10.4 2.4 3 0 0 3 3 3 0 Collagenase NC10 and Endostatin Plasmodium_Vir PF05795.11 CDI86908.1 - 0.26 10.7 31.3 0.037 13.4 10.4 3.0 3 0 0 3 3 3 0 Plasmodium vivax Vir protein DUF2052 PF09747.9 CDI86908.1 - 0.29 11.2 49.7 0.16 12.1 23.0 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Mpp10 PF04006.12 CDI86908.1 - 0.78 8.1 53.6 0.28 9.6 30.0 2.1 2 0 0 2 2 2 0 Mpp10 protein Apt1 PF10351.9 CDI86908.1 - 3.1 6.5 49.9 0.078 11.8 14.9 3.0 3 0 0 3 3 3 0 Golgi-body localisation protein domain CCSAP PF15748.5 CDI86908.1 - 4 7.5 52.5 0.81 9.8 15.7 3.1 3 0 0 3 3 3 0 Centriole, cilia and spindle-associated Utp14 PF04615.13 CDI86908.1 - 6.1 5.3 45.2 0.1 11.1 20.2 2.2 2 0 0 2 2 2 0 Utp14 protein DUF2126 PF09899.9 CDI86908.1 - 6.5 4.7 18.4 0.016 13.3 4.3 2.4 3 0 0 3 3 3 0 Putative amidoligase enzyme (DUF2126) RskA PF10099.9 CDI86909.1 - 9.5e-05 22.8 13.9 9.5e-05 22.8 13.9 14.7 3 3 6 9 9 9 1 Anti-sigma-K factor rskA DUF2514 PF10721.9 CDI86909.1 - 0.002 18.2 8.3 0.002 18.2 8.3 12.3 7 5 3 11 11 11 1 Protein of unknown function (DUF2514) Trp_oprn_chp PF09534.10 CDI86910.1 - 0.0002 21.2 5.0 0.0002 21.2 5.0 4.7 3 1 1 4 4 4 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2227 PF09988.9 CDI86910.1 - 3.8 7.4 10.1 0.21 11.5 0.3 3.2 3 0 0 3 3 3 0 Uncharacterized metal-binding protein (DUF2227) Activator_LAG-3 PF11498.8 CDI86911.1 - 0.034 13.1 26.3 0.067 12.2 26.3 1.5 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.13 CDI86911.1 - 0.83 9.6 22.2 1.4 8.8 22.2 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI86911.1 - 1.6 9.0 20.2 0.45 10.8 7.9 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI86912.1 - 0.0082 16.5 19.4 0.0082 16.5 19.4 3.4 1 1 2 3 3 3 1 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI86913.1 - 0.00042 19.4 5.1 0.00042 19.4 5.1 5.8 4 1 1 5 5 5 3 Transcriptional activator LAG-3 Exonuc_VII_L PF02601.15 CDI86913.1 - 0.049 13.2 0.0 0.049 13.2 0.0 5.0 4 1 0 6 6 6 0 Exonuclease VII, large subunit GP40 PF11025.8 CDI86914.1 - 0.15 11.9 3.6 0.17 11.6 3.6 1.1 1 0 0 1 1 1 0 Glycoprotein GP40 of Cryptosporidium AF-4 PF05110.13 CDI86914.1 - 0.17 10.0 25.9 0.21 9.7 25.9 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein MPM1 PF17234.2 CDI86914.1 - 0.19 12.0 17.5 0.24 11.6 17.5 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 SR-25 PF10500.9 CDI86914.1 - 0.2 11.3 30.2 0.25 10.9 30.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SDP_N PF12278.8 CDI86914.1 - 0.2 11.8 17.1 0.23 11.6 17.1 1.1 1 0 0 1 1 1 0 Sex determination protein N terminal Cwf_Cwc_15 PF04889.12 CDI86914.1 - 0.33 10.7 16.9 0.36 10.5 16.9 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein GREB1 PF15782.5 CDI86914.1 - 0.52 7.4 22.6 0.55 7.3 22.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIA PF03153.13 CDI86914.1 - 0.54 10.2 38.4 0.61 10.0 38.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Plasmodium_Vir PF05795.11 CDI86914.1 - 0.76 9.1 15.4 0.8 9.1 15.4 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PI3K_1B_p101 PF10486.9 CDI86914.1 - 0.84 7.3 17.5 0.94 7.2 17.5 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PMSI1 PF15322.6 CDI86914.1 - 0.99 8.8 12.8 1.1 8.7 12.8 1.0 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Macoilin PF09726.9 CDI86914.1 - 0.99 7.9 22.6 1.1 7.7 22.6 1.0 1 0 0 1 1 1 0 Macoilin family BAT2_N PF07001.11 CDI86914.1 - 1.1 9.7 24.0 1.4 9.3 24.0 1.2 1 0 0 1 1 1 0 BAT2 N-terminus DUF702 PF05142.12 CDI86914.1 - 1.2 9.6 15.4 1.4 9.4 15.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF702) DUF4770 PF15994.5 CDI86914.1 - 1.3 9.2 19.5 1.5 9.1 19.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Tim54 PF11711.8 CDI86914.1 - 2.2 7.0 13.1 2.3 6.9 13.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Spt20 PF12090.8 CDI86914.1 - 2.7 7.6 43.9 3.2 7.3 43.9 1.2 1 0 0 1 1 1 0 Spt20 family DUF4407 PF14362.6 CDI86914.1 - 2.9 7.2 10.6 2.8 7.2 10.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RAP1 PF07218.11 CDI86914.1 - 3 6.0 10.0 3.1 6.0 10.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) FAM76 PF16046.5 CDI86914.1 - 3.4 6.9 22.1 3.8 6.8 22.1 1.0 1 0 0 1 1 1 0 FAM76 protein Peptidase_S64 PF08192.11 CDI86914.1 - 4.5 5.7 22.1 4.7 5.6 22.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 PepSY_TM PF03929.16 CDI86914.1 - 4.5 6.8 6.0 4.5 6.9 6.0 1.1 1 0 0 1 1 1 0 PepSY-associated TM region DUF4718 PF15842.5 CDI86914.1 - 4.9 6.9 16.9 6.4 6.5 16.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) PAT1 PF09770.9 CDI86914.1 - 5.5 5.1 25.5 5.6 5.1 25.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NST1 PF13945.6 CDI86914.1 - 6.2 6.9 25.5 8.3 6.5 25.5 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator EPL1 PF10513.9 CDI86914.1 - 6.4 7.1 19.2 8.6 6.7 19.2 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like MAP65_ASE1 PF03999.12 CDI86914.1 - 6.5 5.3 21.7 7.2 5.2 21.7 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) BRF1 PF07741.13 CDI86914.1 - 6.7 7.1 12.7 8.9 6.7 12.7 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DUF1635 PF07795.11 CDI86914.1 - 7.2 6.4 22.1 8.8 6.1 22.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) SPX PF03105.19 CDI86914.1 - 7.6 6.3 24.1 8.3 6.2 24.1 1.0 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI86914.1 - 9.1 5.0 24.2 10 4.9 24.2 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_S49_N PF08496.10 CDI86914.1 - 9.2 6.3 10.2 9.7 6.2 10.2 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ndc1_Nup PF09531.10 CDI86914.1 - 9.3 4.8 22.6 9.9 4.7 22.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4692 PF15763.5 CDI86914.1 - 9.7 6.6 15.8 13 6.3 15.8 1.1 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) SRP-alpha_N PF04086.13 CDI86914.1 - 9.9 6.0 20.2 11 5.8 20.2 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Tudor-knot PF11717.8 CDI86915.1 - 9.9e-10 38.2 0.1 2.9e-07 30.3 0.0 2.2 2 0 0 2 2 2 2 RNA binding activity-knot of a chromodomain Dehydrin PF00257.19 CDI86915.1 - 0.082 13.5 0.7 0.082 13.5 0.7 3.5 2 1 1 3 3 3 0 Dehydrin RskA PF10099.9 CDI86915.1 - 0.22 11.8 25.5 0.25 11.6 11.6 2.4 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Macoilin PF09726.9 CDI86915.1 - 1.3 7.5 4.7 2.5 6.6 4.7 1.5 1 0 0 1 1 1 0 Macoilin family LRR_4 PF12799.7 CDI86916.1 - 3.4e-05 24.1 1.1 9.8e-05 22.7 1.1 1.8 1 1 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDI86916.1 - 0.00016 21.8 0.3 0.0043 17.4 0.8 2.6 2 0 0 2 2 2 1 Leucine Rich Repeat LRR_8 PF13855.6 CDI86916.1 - 0.00017 21.3 1.3 0.00058 19.6 1.3 1.9 1 1 0 1 1 1 1 Leucine rich repeat LRR_6 PF13516.6 CDI86916.1 - 0.0026 17.7 0.3 0.31 11.2 0.3 2.7 2 0 0 2 2 2 1 Leucine Rich repeat RskA PF10099.9 CDI86917.1 - 0.00093 19.5 73.0 0.011 16.0 17.5 3.9 2 1 0 2 2 2 1 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI86917.1 - 0.01 14.9 32.7 0.039 12.9 4.8 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) DUF1645 PF07816.11 CDI86917.1 - 0.034 14.7 1.3 0.034 14.7 1.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1645) RAP1 PF07218.11 CDI86917.1 - 0.18 10.0 2.2 0.27 9.5 2.2 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) MecA PF05389.12 CDI86917.1 - 0.46 10.1 4.4 6.7 6.3 0.2 2.9 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) tRNA_lig_CPD PF08302.11 CDI86917.1 - 1.6 8.1 10.9 1 8.7 2.6 3.0 3 0 0 3 3 3 0 Fungal tRNA ligase phosphodiesterase domain Pex14_N PF04695.13 CDI86917.1 - 3.3 8.3 43.8 7.9 7.1 5.9 4.3 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pinin_SDK_memA PF04696.13 CDI86918.1 - 0.61 10.2 13.8 1.1 9.4 13.8 1.4 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region Vfa1 PF08432.10 CDI86918.1 - 3.1 8.1 8.9 0.32 11.3 3.8 1.8 1 1 1 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF2722 PF10846.8 CDI86919.1 - 0.0069 15.4 5.1 0.0069 15.4 5.1 6.1 4 1 2 6 6 6 3 Protein of unknown function (DUF2722) DUF1689 PF07954.11 CDI86919.1 - 0.031 14.7 0.4 0.031 14.7 0.4 5.7 6 0 0 6 6 6 0 Protein of unknown function (DUF1689) Methyltransf_12 PF08242.12 CDI86919.1 - 0.31 11.8 0.0 0.31 11.8 0.0 4.8 4 1 1 5 5 5 0 Methyltransferase domain DUF4667 PF15700.5 CDI86920.1 - 0.049 13.7 1.6 0.055 13.6 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) SCP1201-deam PF14428.6 CDI86920.1 - 0.13 12.2 0.2 0.13 12.2 0.2 1.8 1 1 0 2 2 2 0 SCP1.201-like deaminase K1377 PF15352.6 CDI86920.1 - 0.44 8.8 1.7 0.53 8.5 1.7 1.0 1 0 0 1 1 1 0 Susceptibility to monomelic amyotrophy FKS1_dom1 PF14288.6 CDI86921.1 - 0.9 9.9 6.0 1 9.7 6.0 1.1 1 0 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 DUF2722 PF10846.8 CDI86922.1 - 0.0079 15.2 15.6 0.0079 15.2 15.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) SpoIIP PF07454.11 CDI86922.1 - 0.058 12.8 2.3 0.11 12.0 2.3 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Spt20 PF12090.8 CDI86922.1 - 0.083 12.5 35.3 0.033 13.8 21.3 2.1 2 0 0 2 2 2 0 Spt20 family FAM60A PF15396.6 CDI86922.1 - 0.27 11.2 7.6 0.043 13.8 2.6 1.9 2 0 0 2 2 2 0 Protein Family FAM60A DUF4637 PF15470.6 CDI86922.1 - 0.35 10.6 5.3 0.29 10.8 3.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) MAJIN PF15077.6 CDI86922.1 - 0.42 10.4 1.9 0.73 9.6 1.9 1.4 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF2367 PF10164.9 CDI86922.1 - 0.69 10.4 8.4 0.12 12.9 2.5 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2367) STAG PF08514.11 CDI86922.1 - 0.97 9.4 7.2 3 7.8 7.2 1.7 1 0 0 1 1 1 0 STAG domain EPL1 PF10513.9 CDI86922.1 - 1.3 9.4 9.9 1.7 9.0 5.0 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Baculo_PP31 PF05311.11 CDI86922.1 - 1.4 8.3 8.0 2.8 7.4 8.0 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Coilin_N PF15862.5 CDI86922.1 - 1.6 8.5 11.4 3.5 7.4 11.4 1.5 1 0 0 1 1 1 0 Coilin N-terminus TRAP_alpha PF03896.16 CDI86922.1 - 1.8 7.7 6.2 0.12 11.5 0.7 1.7 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Dehydrin PF00257.19 CDI86922.1 - 4 8.0 15.3 1.9 9.0 3.6 2.3 2 0 0 2 2 2 0 Dehydrin DUF4820 PF16091.5 CDI86922.1 - 5.2 6.4 11.0 0.13 11.6 4.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Roughex PF06020.11 CDI86922.1 - 7.7 5.5 18.9 0.041 13.0 7.2 2.0 2 0 0 2 2 2 0 Drosophila roughex protein F-protein PF00469.20 CDI86922.1 - 7.8 6.0 9.3 0.89 9.1 4.2 1.8 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef RskA PF10099.9 CDI86923.1 - 4.9e-05 23.7 4.6 5.4e-05 23.6 4.6 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Ribosomal_60s PF00428.19 CDI86923.1 - 0.00019 21.9 9.4 0.0003 21.3 9.4 1.4 1 0 0 1 1 1 1 60s Acidic ribosomal protein Miga PF10265.9 CDI86923.1 - 0.012 14.7 20.6 0.014 14.4 20.6 1.0 1 0 0 1 1 1 0 Mitoguardin TFIIA PF03153.13 CDI86923.1 - 0.014 15.4 29.4 0.017 15.1 29.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GEMIN8 PF15348.6 CDI86923.1 - 0.023 15.0 18.2 0.029 14.7 18.2 1.1 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 Macoilin PF09726.9 CDI86923.1 - 0.026 13.1 28.0 0.035 12.7 28.0 1.2 1 0 0 1 1 1 0 Macoilin family Spt20 PF12090.8 CDI86923.1 - 0.031 13.9 26.6 0.04 13.5 26.6 1.3 1 0 0 1 1 1 0 Spt20 family BORG_CEP PF14957.6 CDI86923.1 - 0.038 15.2 19.8 0.049 14.8 19.8 1.1 1 0 0 1 1 1 0 Cdc42 effector CytochromB561_N PF09786.9 CDI86923.1 - 0.04 12.9 18.0 0.044 12.8 18.0 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal NEMP PF10225.9 CDI86923.1 - 0.054 13.2 8.3 0.067 12.8 8.3 1.3 1 0 0 1 1 1 0 NEMP family DUF3801 PF12687.7 CDI86923.1 - 0.059 13.4 15.7 0.074 13.1 15.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) SPX PF03105.19 CDI86923.1 - 0.067 13.1 27.9 0.08 12.9 27.9 1.0 1 0 0 1 1 1 0 SPX domain Cwf_Cwc_15 PF04889.12 CDI86923.1 - 0.078 12.7 18.5 0.092 12.5 18.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FHIPEP PF00771.20 CDI86923.1 - 0.17 10.3 3.9 0.17 10.3 3.9 1.1 1 0 0 1 1 1 0 FHIPEP family DUF2151 PF10221.9 CDI86923.1 - 0.22 10.1 12.3 0.25 9.9 12.3 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Lin-8 PF03353.15 CDI86923.1 - 0.23 11.0 22.7 0.27 10.8 22.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SLC12 PF03522.15 CDI86923.1 - 0.28 10.2 18.8 0.3 10.1 18.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PTPRCAP PF15713.5 CDI86923.1 - 0.29 11.4 16.3 0.39 11.0 16.3 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RPOL_N PF14700.6 CDI86923.1 - 0.3 10.4 14.1 0.37 10.1 14.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal Presenilin PF01080.17 CDI86923.1 - 0.47 9.2 25.6 0.54 9.0 25.6 1.1 1 0 0 1 1 1 0 Presenilin Plasmodium_Vir PF05795.11 CDI86923.1 - 0.47 9.8 15.2 0.53 9.7 15.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF1387 PF07139.11 CDI86923.1 - 0.67 9.6 22.6 0.8 9.4 22.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) PNISR PF15996.5 CDI86923.1 - 0.78 10.0 24.0 1.1 9.5 24.0 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR IHABP4_N PF16174.5 CDI86923.1 - 0.79 10.3 23.2 1 10.0 23.2 1.1 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal DUF913 PF06025.12 CDI86923.1 - 0.83 8.6 12.3 1.2 8.0 12.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Membralin PF09746.9 CDI86923.1 - 0.85 8.6 11.3 0.93 8.5 11.3 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF3807 PF12720.7 CDI86923.1 - 0.9 9.8 21.3 1.3 9.3 21.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Neur_chan_memb PF02932.16 CDI86923.1 - 0.93 9.5 11.8 1.1 9.2 11.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SAGA-Tad1 PF12767.7 CDI86923.1 - 0.96 9.1 18.0 1 9.0 18.0 1.0 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit PMSI1 PF15322.6 CDI86923.1 - 1 8.7 18.9 1.2 8.5 18.9 1.0 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative CLN3 PF02487.17 CDI86923.1 - 1.4 7.9 9.0 1.7 7.6 9.0 1.3 1 0 0 1 1 1 0 CLN3 protein FAM70 PF14967.6 CDI86923.1 - 1.4 8.4 11.5 1.7 8.1 11.5 1.0 1 0 0 1 1 1 0 FAM70 protein FCP1_C PF09309.10 CDI86923.1 - 1.4 8.8 24.3 1.7 8.4 24.3 1.1 1 0 0 1 1 1 0 FCP1, C-terminal PepSY_2 PF13670.6 CDI86923.1 - 1.4 9.0 11.6 2.2 8.3 11.6 1.3 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain DUF2052 PF09747.9 CDI86923.1 - 1.6 8.8 14.4 2 8.5 14.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Apt1 PF10351.9 CDI86923.1 - 1.9 7.3 28.1 2.1 7.1 28.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain HSD3 PF15244.6 CDI86923.1 - 2.2 7.7 24.0 2.5 7.5 24.0 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 MDFI PF15316.6 CDI86923.1 - 2.5 8.2 18.5 3.2 7.8 18.5 1.3 1 0 0 1 1 1 0 MyoD family inhibitor TipE PF16972.5 CDI86923.1 - 2.7 7.1 12.9 3.4 6.8 12.9 1.0 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE PAT1 PF09770.9 CDI86923.1 - 2.8 6.1 20.6 3 6.0 20.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Suf PF05843.14 CDI86923.1 - 2.8 7.8 16.9 3.6 7.5 16.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TMEM151 PF14857.6 CDI86923.1 - 2.8 6.8 16.1 3.1 6.6 16.1 1.1 1 0 0 1 1 1 0 TMEM151 family Hydin_ADK PF17213.3 CDI86923.1 - 2.8 8.2 21.5 3.4 7.9 21.5 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain CDC45 PF02724.14 CDI86923.1 - 3 6.0 20.4 3.5 5.8 20.4 1.0 1 0 0 1 1 1 0 CDC45-like protein PI3K_1B_p101 PF10486.9 CDI86923.1 - 3.2 5.4 18.5 3.4 5.3 18.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit GREB1 PF15782.5 CDI86923.1 - 3.3 4.7 26.4 3.9 4.5 26.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAT1 PF06391.13 CDI86923.1 - 3.5 7.4 20.1 4 7.2 20.1 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 FAM60A PF15396.6 CDI86923.1 - 3.6 7.6 20.2 4.2 7.3 20.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CAML PF14963.6 CDI86923.1 - 3.6 7.6 12.3 4.5 7.3 12.3 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand ALMT PF11744.8 CDI86923.1 - 3.8 6.2 18.3 4.1 6.1 18.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter ANAPC1 PF12859.7 CDI86923.1 - 3.9 8.0 17.1 5.3 7.6 17.1 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 MAP65_ASE1 PF03999.12 CDI86923.1 - 3.9 6.0 24.9 4.8 5.7 24.9 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Hid1 PF12722.7 CDI86923.1 - 3.9 5.5 20.2 4.1 5.4 20.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Utp14 PF04615.13 CDI86923.1 - 4.1 5.8 26.3 4.6 5.7 26.3 1.0 1 0 0 1 1 1 0 Utp14 protein Mem_trans PF03547.18 CDI86923.1 - 4.3 5.6 13.0 5.1 5.4 13.0 1.2 1 0 0 1 1 1 0 Membrane transport protein Ndc1_Nup PF09531.10 CDI86923.1 - 4.8 5.8 21.4 5 5.7 21.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF572 PF04502.13 CDI86923.1 - 4.8 6.7 23.9 5.7 6.5 23.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) API5 PF05918.11 CDI86923.1 - 5.6 5.6 16.6 6.7 5.4 16.6 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Peroxin-3 PF04882.12 CDI86923.1 - 5.9 5.8 22.9 7 5.5 22.9 1.2 1 0 0 1 1 1 0 Peroxin-3 Dicty_REP PF05086.12 CDI86923.1 - 5.9 4.7 17.6 6.4 4.6 17.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Smg8_Smg9 PF10220.9 CDI86923.1 - 6.8 4.9 22.2 7.8 4.7 22.2 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Herpes_pp85 PF04637.12 CDI86923.1 - 7 4.9 13.6 7.7 4.8 13.6 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) V_ATPase_I PF01496.19 CDI86923.1 - 7.1 4.4 13.4 8.7 4.1 13.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S64 PF08192.11 CDI86923.1 - 7.5 4.9 27.1 8.6 4.7 27.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Sec62 PF03839.16 CDI86923.1 - 7.5 6.0 13.4 9.8 5.6 13.4 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 RAP1 PF07218.11 CDI86923.1 - 7.9 4.6 21.7 8.9 4.4 21.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) O-antigen_lig PF13425.6 CDI86923.1 - 9.1 4.9 8.1 9.9 4.8 8.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SRP-alpha_N PF04086.13 CDI86923.1 - 9.1 6.1 27.5 12 5.8 27.5 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Spt20 PF12090.8 CDI86924.1 - 0.00036 20.2 16.4 0.00036 20.2 16.4 3.8 3 1 0 3 3 3 2 Spt20 family DUF2722 PF10846.8 CDI86924.1 - 0.0015 17.6 9.8 0.0015 17.6 9.8 3.8 3 1 1 4 4 4 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI86924.1 - 0.015 15.6 17.0 0.015 15.6 17.0 4.1 1 1 2 3 3 3 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI86926.1 - 0.00041 20.7 3.5 0.00041 20.7 3.5 13.2 1 1 9 10 10 10 3 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI86926.1 - 0.005 15.8 15.0 0.005 15.8 15.0 12.7 9 3 2 11 11 11 3 Protein of unknown function (DUF2722) zf-CCCH PF00642.24 CDI86927.1 - 0.003 17.4 1.0 0.0057 16.5 1.0 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDI86927.1 - 0.028 14.5 0.5 0.059 13.4 0.5 1.6 1 0 0 1 1 1 0 Zinc finger domain FBPase_glpX PF03320.13 CDI86927.1 - 0.076 11.9 0.1 0.24 10.2 0.2 1.7 2 0 0 2 2 2 0 Bacterial fructose-1,6-bisphosphatase, glpX-encoded TERB2 PF15101.6 CDI86928.1 - 0.43 10.6 3.8 0.65 10.0 3.8 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TFIIA PF03153.13 CDI86928.1 - 0.92 9.4 12.2 1.4 8.8 12.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit cEGF PF12662.7 CDI86929.1 - 0.0087 16.0 0.9 0.0087 16.0 0.9 6.6 7 0 0 7 7 7 3 Complement Clr-like EGF-like FXa_inhibition PF14670.6 CDI86929.1 - 0.022 15.0 67.2 0.042 14.1 3.9 6.3 5 1 0 5 5 5 0 Coagulation Factor Xa inhibitory site stn_TNFRSF12A PF12191.8 CDI86929.1 - 0.085 13.1 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain EGF_3 PF12947.7 CDI86929.1 - 6.8 7.0 55.0 0.11 12.7 11.2 6.3 5 1 1 6 6 6 0 EGF domain Nucleoside_tran PF01733.18 CDI86931.1 - 3e-15 56.4 10.4 5e-15 55.7 10.4 1.3 1 0 0 1 1 1 1 Nucleoside transporter AT_hook PF02178.19 CDI86932.1 - 1.3 9.1 5.1 3.2 7.9 5.1 1.7 1 0 0 1 1 1 0 AT hook motif RRM_1 PF00076.22 CDI86933.1 - 2.6e-08 33.5 0.0 3.8e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LSM PF01423.22 CDI86934.1 - 1.4e-15 56.7 0.7 2.4e-15 56.0 0.7 1.4 1 0 0 1 1 1 1 LSM domain DUF4787 PF16029.5 CDI86934.1 - 0.034 14.2 0.1 0.063 13.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4787) Hfq PF17209.3 CDI86934.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Hfq protein IMCp PF12314.8 CDI86935.1 - 1.3e-30 105.5 90.9 2.6e-17 62.9 37.4 4.3 1 1 3 4 4 4 4 Inner membrane complex protein IMCp PF12314.8 CDI86936.1 - 1.1e-26 93.0 62.5 2e-26 92.1 41.8 5.6 3 2 2 5 5 5 2 Inner membrane complex protein NAD_binding_4 PF07993.12 CDI86937.1 - 4.1e-55 186.7 0.0 6.7e-55 186.0 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Sulfotransfer_3 PF13469.6 CDI86937.1 - 7.8e-43 147.4 0.1 2.2e-42 145.9 0.1 1.8 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 CDI86937.1 - 6.1e-17 62.0 0.1 1.5e-16 60.7 0.1 1.6 1 1 0 1 1 1 1 Sulfotransferase domain PP-binding PF00550.25 CDI86937.1 - 8e-12 45.3 0.0 2.9e-11 43.6 0.0 2.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 CDI86937.1 - 5.5e-09 35.8 0.0 9.7e-09 35.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sulfotransfer_4 PF17784.1 CDI86937.1 - 0.00047 20.1 0.4 0.0087 15.9 0.1 2.8 3 0 0 3 3 3 1 Sulfotransferase domain GDP_Man_Dehyd PF16363.5 CDI86937.1 - 0.078 12.4 0.0 0.37 10.2 0.0 2.1 3 0 0 3 3 3 0 GDP-mannose 4,6 dehydratase DUF1331 PF07048.11 CDI86937.1 - 0.11 12.1 0.2 0.8 9.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1331) DUF3675 PF12428.8 CDI86938.1 - 0.0082 16.7 0.0 0.0082 16.7 0.0 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF3675) Rax2 PF12768.7 CDI86938.1 - 0.009 15.5 2.2 0.012 15.1 2.2 1.1 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Peptidase_M56 PF05569.11 CDI86938.1 - 0.028 13.6 0.7 0.034 13.3 0.7 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 Tmemb_161AB PF10268.9 CDI86938.1 - 0.036 12.7 0.3 0.048 12.3 0.3 1.1 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB DUF3446 PF11928.8 CDI86938.1 - 0.036 14.4 9.9 0.049 13.9 9.9 1.2 1 0 0 1 1 1 0 Early growth response N-terminal domain DUF5383 PF17355.2 CDI86938.1 - 0.066 13.6 0.5 0.066 13.6 0.5 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF5383) PH_5 PF15405.6 CDI86938.1 - 0.073 13.2 0.1 0.086 12.9 0.1 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain MRAP PF15183.6 CDI86938.1 - 0.53 10.3 3.9 2.7 8.0 0.3 2.2 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family SR-25 PF10500.9 CDI86938.1 - 1.1 8.9 14.9 1.2 8.7 14.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Fig1 PF12351.8 CDI86938.1 - 1.7 8.6 7.7 6.5 6.6 1.3 2.2 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 FAM199X PF15814.5 CDI86938.1 - 5 6.1 11.4 6 5.8 11.4 1.1 1 0 0 1 1 1 0 Protein family FAM199X TMEM154 PF15102.6 CDI86938.1 - 5.8 6.8 9.7 0.11 12.4 2.1 1.8 1 1 1 2 2 2 0 TMEM154 protein family ubiquitin PF00240.23 CDI86939.1 - 1.6e-08 34.2 0.0 3.4e-07 29.9 0.0 3.0 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD_2 PF13881.6 CDI86939.1 - 6e-07 29.6 0.0 6e-07 29.6 0.0 5.0 5 2 1 6 6 6 1 Ubiquitin-2 like Rad60 SUMO-like DUF2722 PF10846.8 CDI86939.1 - 0.0039 16.2 6.4 0.0039 16.2 6.4 6.6 3 1 2 6 6 6 2 Protein of unknown function (DUF2722) Rad60-SLD PF11976.8 CDI86939.1 - 0.0045 16.8 1.7 0.011 15.6 0.0 2.5 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 CDI86939.1 - 0.016 15.8 1.3 1.8 9.3 1.3 3.3 1 1 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD GWT1 PF06423.12 CDI86939.1 - 0.49 10.5 0.0 0.49 10.5 0.0 3.8 3 1 0 3 3 3 0 GWT1 zf-HIT PF04438.16 CDI86940.1 - 1.5e-07 31.1 12.4 2.7e-07 30.3 12.4 1.4 1 0 0 1 1 1 1 HIT zinc finger ESM4 PF15952.5 CDI86940.1 - 0.00021 21.7 8.2 0.00021 21.7 8.2 3.5 2 1 0 3 3 3 1 Enhancer of split M4 family SpoIIIAH PF12685.7 CDI86940.1 - 0.014 15.3 40.5 0.39 10.5 11.0 3.2 3 0 0 3 3 3 0 SpoIIIAH-like protein DUF2990 PF11693.8 CDI86940.1 - 0.015 15.5 0.0 0.065 13.4 0.0 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2990) PEHE PF15275.6 CDI86940.1 - 0.022 15.4 9.0 0.022 15.4 9.0 3.4 3 0 0 3 3 3 0 PEHE domain zf-MYND PF01753.18 CDI86940.1 - 0.68 10.1 14.9 1.9 8.6 14.9 1.8 1 0 0 1 1 1 0 MYND finger Ribosomal_60s PF00428.19 CDI86941.1 - 2.5 8.7 12.5 4 8.1 12.5 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein zf-CpG_bind_C PF12269.8 CDI86942.1 - 0.32 10.7 18.6 0.36 10.6 18.6 1.0 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain CTU2 PF10288.9 CDI86942.1 - 0.33 11.2 18.6 0.48 10.7 18.6 1.3 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 DUF5427 PF10310.9 CDI86942.1 - 0.89 8.4 18.4 0.91 8.4 18.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) FAM163 PF15069.6 CDI86942.1 - 1.2 9.6 12.8 1.2 9.5 12.8 1.0 1 0 0 1 1 1 0 FAM163 family MecA PF05389.12 CDI86942.1 - 1.5 8.4 17.4 2.2 7.9 17.4 1.2 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) FAM176 PF14851.6 CDI86942.1 - 2 8.1 15.3 2.2 7.9 15.3 1.1 1 0 0 1 1 1 0 FAM176 family DUF3306 PF11748.8 CDI86942.1 - 2.1 9.2 15.3 2.3 9.1 15.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Tim54 PF11711.8 CDI86942.1 - 2.2 7.0 18.6 2.1 7.1 18.6 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Pex14_N PF04695.13 CDI86942.1 - 2.3 8.9 18.1 2.4 8.8 18.1 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CCDC53 PF10152.9 CDI86942.1 - 3.2 8.1 17.4 3.3 8.1 17.4 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Spt20 PF12090.8 CDI86942.1 - 3.5 7.2 37.7 3.8 7.1 37.7 1.1 1 0 0 1 1 1 0 Spt20 family Eapp_C PF10238.9 CDI86942.1 - 4 7.5 21.6 4.5 7.3 21.6 1.0 1 0 0 1 1 1 0 E2F-associated phosphoprotein Na_trans_assoc PF06512.13 CDI86942.1 - 4.9 7.4 16.7 5.2 7.3 16.7 1.0 1 0 0 1 1 1 0 Sodium ion transport-associated Peptidase_S49_N PF08496.10 CDI86942.1 - 5.4 7.1 16.8 6.2 6.9 16.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal EOS1 PF12326.8 CDI86942.1 - 7 6.5 10.7 7 6.6 10.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein Velvet PF11754.8 CDI86942.1 - 8.4 6.2 15.4 8.4 6.2 15.4 1.0 1 0 0 1 1 1 0 Velvet factor DUF2828 PF11443.8 CDI86942.1 - 8.5 4.3 18.9 8.4 4.3 18.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CPSF100_C PF13299.6 CDI86942.1 - 8.7 6.5 16.0 9.6 6.4 16.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RBP_receptor PF14752.6 CDI86942.1 - 9.2 4.7 9.5 11 4.5 9.5 1.3 1 0 0 1 1 1 0 Retinol binding protein receptor GNAT_acetyltr_2 PF13718.6 CDI86942.1 - 10 5.5 13.4 10 5.4 13.4 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 LMBR1 PF04791.16 CDI86943.1 - 4.8e-09 35.7 8.1 5.9e-08 32.1 7.8 2.3 2 0 0 2 2 2 1 LMBR1-like membrane protein Fe_hyd_lg_C PF02906.14 CDI86943.1 - 2.7e-07 30.5 2.4 0.0017 18.0 0.0 3.4 3 0 0 3 3 2 2 Iron only hydrogenase large subunit, C-terminal domain DUF2722 PF10846.8 CDI86943.1 - 3e-05 23.2 5.1 3e-05 23.2 5.1 5.9 4 1 1 5 5 3 1 Protein of unknown function (DUF2722) PNISR PF15996.5 CDI86943.1 - 3.9e-05 24.0 31.9 3.9e-05 24.0 31.9 4.0 4 0 0 4 4 4 1 Arginine/serine-rich protein PNISR Shisa PF13908.6 CDI86943.1 - 0.00018 21.8 3.7 0.00018 21.8 3.7 5.3 4 1 1 5 5 4 1 Wnt and FGF inhibitory regulator Lin-8 PF03353.15 CDI86943.1 - 0.00067 19.3 29.6 0.00067 19.3 29.6 4.1 4 0 0 4 4 4 1 Ras-mediated vulval-induction antagonist MID_MedPIWI PF18296.1 CDI86943.1 - 0.0025 17.7 2.4 0.0025 17.7 2.4 3.4 2 1 0 3 3 2 1 MID domain of medPIWI RskA PF10099.9 CDI86943.1 - 0.0029 17.9 12.8 0.0029 17.9 12.8 9.6 4 2 3 7 7 4 1 Anti-sigma-K factor rskA Tweety PF04906.13 CDI86943.1 - 0.004 15.9 10.4 0.004 15.9 10.4 2.7 1 1 1 2 2 1 1 Tweety ANAPC_CDC26 PF10471.9 CDI86943.1 - 0.011 16.6 12.9 0.011 16.6 12.9 6.9 5 1 0 5 5 3 0 Anaphase-promoting complex APC subunit CDC26 DUF1645 PF07816.11 CDI86943.1 - 0.011 16.3 4.9 0.011 16.3 4.9 5.7 4 1 0 4 4 3 0 Protein of unknown function (DUF1645) DUF2207 PF09972.9 CDI86943.1 - 0.017 13.9 0.0 0.017 13.9 0.0 2.0 2 1 0 2 2 1 0 Predicted membrane protein (DUF2207) UL45 PF05473.12 CDI86943.1 - 0.024 14.3 1.6 0.046 13.4 0.0 2.3 2 1 0 2 2 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Adaptin_binding PF10199.9 CDI86943.1 - 0.071 13.7 0.0 0.071 13.7 0.0 4.5 2 2 0 2 2 1 0 Alpha and gamma adaptin binding protein p34 SAPS PF04499.15 CDI86943.1 - 0.077 11.8 33.9 0.04 12.7 20.7 3.0 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein Wzy_C PF04932.15 CDI86943.1 - 0.13 11.9 0.2 0.43 10.2 0.2 1.9 1 0 0 1 1 1 0 O-Antigen ligase DUF1676 PF07898.13 CDI86943.1 - 5.5 7.0 18.7 0.091 12.8 8.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) DUF4834 PF16118.5 CDI86943.1 - 6.6 7.8 0.0 2.9 8.9 7.6 7.0 5 1 0 5 5 4 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI86944.1 - 0.0024 17.5 31.4 0.0026 17.4 31.4 1.0 1 0 0 1 1 1 1 Spt20 family RskA PF10099.9 CDI86944.1 - 0.034 14.4 13.9 0.046 14.0 13.9 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI86944.1 - 0.07 13.1 29.2 0.077 13.0 29.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CobT PF06213.12 CDI86944.1 - 0.074 12.4 20.9 0.082 12.3 20.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TERB2 PF15101.6 CDI86944.1 - 0.1 12.6 15.5 0.11 12.5 15.5 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SelP_N PF04592.14 CDI86944.1 - 0.11 11.9 8.7 0.13 11.7 8.7 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF3408 PF11888.8 CDI86944.1 - 0.15 12.2 8.7 0.17 12.0 8.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Coilin_N PF15862.5 CDI86944.1 - 0.16 11.7 12.8 0.21 11.4 12.8 1.3 1 0 0 1 1 1 0 Coilin N-terminus BAF1_ABF1 PF04684.13 CDI86944.1 - 0.17 10.9 16.5 0.2 10.7 16.5 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4820 PF16091.5 CDI86944.1 - 0.2 11.0 11.5 0.22 10.8 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Paf1 PF03985.13 CDI86944.1 - 0.2 10.6 17.8 0.23 10.4 17.8 1.0 1 0 0 1 1 1 0 Paf1 API5 PF05918.11 CDI86944.1 - 0.23 10.2 13.4 0.24 10.2 13.4 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Presenilin PF01080.17 CDI86944.1 - 0.27 9.9 17.4 0.27 9.9 17.4 1.0 1 0 0 1 1 1 0 Presenilin Med15 PF09606.10 CDI86944.1 - 0.29 9.8 25.1 0.3 9.7 25.1 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TRAP_alpha PF03896.16 CDI86944.1 - 0.31 10.2 9.4 0.33 10.1 9.4 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BAT2_N PF07001.11 CDI86944.1 - 0.32 11.4 19.3 0.35 11.3 19.3 1.1 1 0 0 1 1 1 0 BAT2 N-terminus SpoIIP PF07454.11 CDI86944.1 - 0.33 10.4 14.1 0.36 10.2 14.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Pannexin_like PF12534.8 CDI86944.1 - 0.39 9.8 7.6 0.44 9.6 7.6 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DnaJ-X PF14308.6 CDI86944.1 - 0.5 9.8 10.1 0.56 9.6 10.1 1.1 1 0 0 1 1 1 0 X-domain of DnaJ-containing THOC2_N PF16134.5 CDI86944.1 - 0.54 8.8 12.5 0.57 8.7 12.5 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus DDHD PF02862.17 CDI86944.1 - 0.56 10.3 12.3 0.62 10.2 12.3 1.1 1 0 0 1 1 1 0 DDHD domain FAM176 PF14851.6 CDI86944.1 - 0.59 9.8 7.5 0.65 9.6 7.5 1.2 1 0 0 1 1 1 0 FAM176 family RR_TM4-6 PF06459.12 CDI86944.1 - 0.65 9.8 13.9 0.72 9.6 13.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Band_3_cyto PF07565.13 CDI86944.1 - 0.75 9.6 9.9 0.84 9.4 9.9 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FYDLN_acid PF09538.10 CDI86944.1 - 0.77 10.5 13.4 1 10.1 13.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Menin PF05053.13 CDI86944.1 - 0.77 8.0 13.3 0.98 7.7 13.3 1.2 1 0 0 1 1 1 0 Menin SRP-alpha_N PF04086.13 CDI86944.1 - 0.81 9.6 15.7 0.87 9.5 15.7 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CPSF100_C PF13299.6 CDI86944.1 - 0.82 9.8 13.9 0.98 9.6 13.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal YABBY PF04690.13 CDI86944.1 - 0.87 10.1 7.5 1 9.9 7.5 1.1 1 0 0 1 1 1 0 YABBY protein Lin-8 PF03353.15 CDI86944.1 - 0.89 9.1 14.7 0.91 9.0 14.7 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SLC12 PF03522.15 CDI86944.1 - 0.95 8.4 11.8 0.99 8.4 11.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4746 PF15928.5 CDI86944.1 - 1 8.8 9.3 1.1 8.7 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RICTOR_N PF14664.6 CDI86944.1 - 1.2 8.1 3.1 1.3 8.0 3.1 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term PAT1 PF09770.9 CDI86944.1 - 1.3 7.2 18.1 1.4 7.1 18.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RNA_pol_Rpc4 PF05132.14 CDI86944.1 - 1.4 9.4 13.5 1.8 9.0 13.5 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Connexin PF00029.19 CDI86944.1 - 1.4 8.7 8.0 1.4 8.6 8.0 1.1 1 0 0 1 1 1 0 Connexin FAM60A PF15396.6 CDI86944.1 - 1.4 8.9 8.2 1.5 8.8 8.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF2828 PF11443.8 CDI86944.1 - 1.4 6.9 12.4 1.5 6.8 12.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SprA-related PF12118.8 CDI86944.1 - 1.4 8.0 30.0 1.7 7.7 30.0 1.1 1 0 0 1 1 1 0 SprA-related family Neur_chan_memb PF02932.16 CDI86944.1 - 1.4 8.9 8.8 1.4 8.9 8.8 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI86944.1 - 1.4 7.6 8.5 1.5 7.5 8.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Plasmodium_Vir PF05795.11 CDI86944.1 - 1.5 8.2 10.4 1.5 8.2 10.4 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Hid1 PF12722.7 CDI86944.1 - 1.5 6.8 12.3 1.6 6.8 12.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SGIII PF15467.6 CDI86944.1 - 1.5 8.0 14.8 1.7 7.8 14.8 1.0 1 0 0 1 1 1 0 Secretogranin-3 DUF4228 PF14009.6 CDI86944.1 - 1.6 9.1 7.9 1.9 8.8 7.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) DUF2722 PF10846.8 CDI86944.1 - 1.6 7.6 29.0 1.9 7.3 29.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Baculo_PP31 PF05311.11 CDI86944.1 - 1.6 8.1 10.5 1.7 8.1 10.5 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) REC114-like PF15165.6 CDI86944.1 - 1.7 8.4 15.0 1.9 8.2 15.0 1.1 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like Roughex PF06020.11 CDI86944.1 - 1.7 7.7 17.8 1.9 7.5 17.8 1.1 1 0 0 1 1 1 0 Drosophila roughex protein FAM70 PF14967.6 CDI86944.1 - 1.7 8.0 8.6 2 7.8 8.6 1.0 1 0 0 1 1 1 0 FAM70 protein CDC45 PF02724.14 CDI86944.1 - 1.7 6.8 12.3 1.9 6.7 12.3 1.0 1 0 0 1 1 1 0 CDC45-like protein BT1 PF03092.16 CDI86944.1 - 1.8 6.7 3.4 2 6.5 3.4 1.0 1 0 0 1 1 1 0 BT1 family Ndc1_Nup PF09531.10 CDI86944.1 - 1.9 7.1 10.6 1.9 7.1 10.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MMU163 PF17119.5 CDI86944.1 - 2 7.5 7.9 2.1 7.4 7.9 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis eIF-3_zeta PF05091.12 CDI86944.1 - 2.1 7.2 16.7 2.3 7.1 16.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PPL5 PF18168.1 CDI86944.1 - 2.2 7.5 10.2 2.4 7.4 10.2 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF4175 PF13779.6 CDI86944.1 - 2.2 6.1 26.0 2.2 6.1 26.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Velvet PF11754.8 CDI86944.1 - 2.3 8.1 12.3 2.5 8.0 12.3 1.0 1 0 0 1 1 1 0 Velvet factor V_ATPase_I PF01496.19 CDI86944.1 - 2.7 5.8 13.0 2.9 5.7 13.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EPL1 PF10513.9 CDI86944.1 - 2.8 8.3 18.2 3.4 8.0 18.2 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF1180 PF06679.12 CDI86944.1 - 2.8 8.3 10.9 3.3 8.1 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) EIIBC-GUT_N PF03612.14 CDI86944.1 - 2.8 7.6 11.7 3.5 7.3 11.7 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus GREB1 PF15782.5 CDI86944.1 - 2.9 4.9 12.5 3.1 4.8 12.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF3402 PF11882.8 CDI86944.1 - 2.9 6.9 10.9 3.3 6.7 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) DREPP PF05558.12 CDI86944.1 - 2.9 7.7 11.1 3.5 7.5 11.1 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Dicty_REP PF05086.12 CDI86944.1 - 3.2 5.6 8.9 3.5 5.5 8.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Spore_coat_CotO PF14153.6 CDI86944.1 - 3.3 7.6 19.1 3.8 7.4 19.1 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Pex26 PF07163.12 CDI86944.1 - 3.5 6.9 11.2 4 6.7 11.2 1.1 1 0 0 1 1 1 0 Pex26 protein XAP5 PF04921.14 CDI86944.1 - 3.5 7.4 11.0 3.8 7.3 11.0 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator Membralin PF09746.9 CDI86944.1 - 3.7 6.5 5.9 3.7 6.5 5.9 1.0 1 0 0 1 1 1 0 Tumour-associated protein Gti1_Pac2 PF09729.9 CDI86944.1 - 3.8 7.6 12.0 4.4 7.4 12.0 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family G0-G1_switch_2 PF15103.6 CDI86944.1 - 3.8 8.0 8.1 5.1 7.6 8.1 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 ATAD4 PF15321.6 CDI86944.1 - 3.9 8.9 9.6 5.8 8.3 9.6 1.4 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 DUF4407 PF14362.6 CDI86944.1 - 4 6.7 20.1 4.5 6.5 20.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF913 PF06025.12 CDI86944.1 - 4.1 6.3 11.4 4.4 6.2 11.4 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) XRN_M PF17846.1 CDI86944.1 - 4.3 6.2 9.5 4.3 6.2 9.5 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Hamartin PF04388.12 CDI86944.1 - 4.3 5.9 11.1 4.7 5.8 11.1 1.0 1 0 0 1 1 1 0 Hamartin protein UPF0560 PF10577.9 CDI86944.1 - 4.7 5.6 19.3 5.3 5.4 19.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Raftlin PF15250.6 CDI86944.1 - 4.9 5.8 12.2 5.2 5.7 12.2 1.0 1 0 0 1 1 1 0 Raftlin MDM31_MDM32 PF08118.11 CDI86944.1 - 5.1 5.6 8.1 5.5 5.5 8.1 1.2 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins PIP5K PF01504.18 CDI86944.1 - 5.2 6.2 10.1 5.2 6.2 10.1 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Ctr PF04145.15 CDI86944.1 - 5.4 7.6 6.1 6.7 7.3 6.1 1.3 1 0 0 1 1 1 0 Ctr copper transporter family SAPS PF04499.15 CDI86944.1 - 5.4 5.7 15.4 5.9 5.6 15.4 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PepSY_TM PF03929.16 CDI86944.1 - 5.8 6.5 7.4 7.2 6.2 7.4 1.3 1 0 0 1 1 1 0 PepSY-associated TM region Tim54 PF11711.8 CDI86944.1 - 5.8 5.6 14.4 6.5 5.4 14.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Activator_LAG-3 PF11498.8 CDI86944.1 - 5.9 5.7 31.8 6.3 5.7 31.8 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 MAJIN PF15077.6 CDI86944.1 - 5.9 6.6 10.1 6.7 6.4 10.1 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein NPR3 PF03666.13 CDI86944.1 - 6.1 5.5 14.1 6.8 5.4 14.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ureide_permease PF07168.11 CDI86944.1 - 6.5 5.4 9.2 7.4 5.2 9.2 1.1 1 0 0 1 1 1 0 Ureide permease Sec62 PF03839.16 CDI86944.1 - 7.6 6.0 9.6 8.8 5.8 9.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 EOS1 PF12326.8 CDI86944.1 - 7.7 6.4 7.4 8.5 6.3 7.4 1.1 1 0 0 1 1 1 0 N-glycosylation protein Paramyxo_ncap PF00973.19 CDI86944.1 - 7.9 5.3 9.5 8.2 5.2 9.5 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein F-protein PF00469.20 CDI86944.1 - 8.4 5.9 10.7 8.6 5.9 10.7 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef SID-1_RNA_chan PF13965.6 CDI86944.1 - 8.8 4.6 7.1 9.3 4.5 7.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 HA2 PF04408.23 CDI86944.1 - 9.1 6.6 11.0 13 6.1 11.0 1.4 1 1 0 1 1 1 0 Helicase associated domain (HA2) FHIPEP PF00771.20 CDI86944.1 - 9.4 4.6 9.8 10 4.4 9.8 1.0 1 0 0 1 1 1 0 FHIPEP family DUF5521 PF17659.1 CDI86944.1 - 9.7 3.9 10.0 10 3.8 10.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5521) RskA PF10099.9 CDI86945.1 - 4.4e-10 40.2 36.7 4e-07 30.5 5.1 26.5 3 3 14 18 18 18 6 Anti-sigma-K factor rskA Fcf2 PF08698.11 CDI86946.1 - 1e-06 29.0 5.7 1.6e-05 25.2 5.7 2.6 1 1 0 1 1 1 1 Fcf2 pre-rRNA processing Hamartin PF04388.12 CDI86946.1 - 3.6 6.1 46.7 5 5.7 46.7 1.2 1 0 0 1 1 1 0 Hamartin protein AF-4 PF05110.13 CDI86947.1 - 0.00013 20.2 14.8 0.00016 19.9 14.8 1.1 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Peptidase_S64 PF08192.11 CDI86947.1 - 0.29 9.6 8.1 0.33 9.4 8.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Apt1 PF10351.9 CDI86947.1 - 0.45 9.3 6.0 0.51 9.1 6.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Hamartin PF04388.12 CDI86947.1 - 1.3 7.6 11.9 1.5 7.4 11.9 1.1 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 CDI86947.1 - 3.6 4.6 9.3 4 4.4 9.3 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ndc1_Nup PF09531.10 CDI86947.1 - 3.9 6.0 12.7 4.2 5.9 12.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Drf_FH1 PF06346.12 CDI86948.1 - 0.00012 21.9 15.6 0.00036 20.3 15.6 1.8 1 0 0 1 1 1 1 Formin Homology Region 1 SUIM_assoc PF16619.5 CDI86948.1 - 0.0045 17.0 0.7 0.0045 17.0 0.7 9.1 5 3 2 7 7 7 1 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 CDI86948.1 - 0.0056 15.7 11.4 0.0056 15.7 11.4 5.0 5 1 0 5 5 5 2 Protein of unknown function (DUF2722) SR-25 PF10500.9 CDI86949.1 - 0.0017 18.0 20.5 0.0017 18.0 20.5 3.3 2 1 1 3 3 3 2 Nuclear RNA-splicing-associated protein DUF5345 PF17280.2 CDI86949.1 - 0.05 13.6 0.9 0.05 13.6 0.9 5.5 2 1 2 4 4 4 0 Family of unknown function (DUF5345) zf-RING_2 PF13639.6 CDI86950.1 - 9.9e-11 41.8 1.8 1.3e-10 41.4 1.8 1.2 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CDI86950.1 - 4.8e-08 33.2 2.1 4.8e-08 33.2 2.1 2.1 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 CDI86950.1 - 5.2e-06 26.2 0.7 8.4e-06 25.6 0.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDI86950.1 - 1.3e-05 24.9 1.9 2e-05 24.3 1.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 CDI86950.1 - 6.4e-05 23.0 1.3 0.00016 21.7 1.3 1.7 1 0 0 1 1 1 1 RING-variant domain zf-RING_5 PF14634.6 CDI86950.1 - 0.00011 22.1 0.5 0.00011 22.1 0.5 1.8 2 1 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDI86950.1 - 0.00011 22.0 0.9 0.00019 21.2 0.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF5318 PF17249.2 CDI86950.1 - 0.00026 20.8 0.3 0.00031 20.5 0.3 1.3 1 1 0 1 1 1 1 Family of unknown function (DUF5318) zf-ANAPC11 PF12861.7 CDI86950.1 - 0.00028 20.9 0.5 0.00028 20.9 0.5 1.8 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 CDI86950.1 - 0.00057 19.7 1.5 0.0012 18.7 1.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Spt20 PF12090.8 CDI86950.1 - 0.0022 17.7 24.1 0.0022 17.7 24.1 1.1 1 0 0 1 1 1 1 Spt20 family Coilin_N PF15862.5 CDI86950.1 - 0.0043 16.9 2.8 0.0043 16.9 2.8 1.2 1 0 0 1 1 1 1 Coilin N-terminus zf-P11 PF03854.14 CDI86950.1 - 0.0047 16.6 0.7 0.0064 16.1 0.7 1.2 1 0 0 1 1 1 1 P-11 zinc finger zf-RING_11 PF17123.5 CDI86950.1 - 0.0059 16.3 2.2 0.014 15.2 0.1 2.2 2 0 0 2 2 2 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 CDI86950.1 - 0.01 15.4 1.2 0.019 14.6 1.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 CDI86950.1 - 0.012 15.3 0.4 0.02 14.7 0.4 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain CTU2 PF10288.9 CDI86950.1 - 0.028 14.7 8.8 0.033 14.4 8.8 1.2 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 RAG1_imp_bd PF12560.8 CDI86950.1 - 0.036 13.6 7.4 0.04 13.5 7.4 1.0 1 0 0 1 1 1 0 RAG1 importin binding DUF4471 PF14740.6 CDI86950.1 - 0.096 11.9 5.1 0.11 11.7 5.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) FANCL_C PF11793.8 CDI86950.1 - 0.14 12.4 4.3 2 8.7 4.4 2.3 1 1 1 2 2 2 0 FANCL C-terminal domain TERB2 PF15101.6 CDI86950.1 - 0.18 11.8 10.3 0.18 11.8 10.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4834 PF16118.5 CDI86950.1 - 0.21 12.6 9.4 0.27 12.2 9.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 CDI86950.1 - 0.85 8.3 8.0 0.83 8.4 8.0 1.1 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI86950.1 - 1.6 8.7 27.0 1.5 8.7 27.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI86950.1 - 2.3 8.1 16.2 2.4 8.1 16.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF5349 PF17298.2 CDI86950.1 - 6.7 6.4 15.5 7.3 6.3 15.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5349) RskA PF10099.9 CDI86951.1 - 0.007 16.7 20.7 0.007 16.7 20.7 10.8 4 3 3 7 7 7 3 Anti-sigma-K factor rskA IMS PF00817.20 CDI86952.1 - 4.5e-10 39.7 5.0 9.2e-06 25.7 0.8 3.3 1 1 0 2 2 2 2 impB/mucB/samB family SDA1 PF05285.12 CDI86952.1 - 0.02 14.3 51.8 0.014 14.9 9.6 4.6 4 0 0 4 4 4 0 SDA1 Dynamin_N PF00350.23 CDI86952.1 - 0.56 10.2 20.6 0.43 10.6 1.7 3.8 3 0 0 3 3 3 0 Dynamin family ATP-synt_10 PF05176.14 CDI86953.1 - 0.033 13.4 0.0 0.052 12.8 0.0 1.2 1 0 0 1 1 1 0 ATP10 protein SR-25 PF10500.9 CDI86955.1 - 0.00039 20.1 24.4 0.00043 19.9 24.4 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4604 PF15377.6 CDI86955.1 - 0.052 14.0 16.6 0.061 13.7 16.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) EBP50_C PF09007.11 CDI86955.1 - 0.29 12.1 22.3 0.37 11.8 22.3 1.0 1 0 0 1 1 1 0 EBP50, C-terminal CDK2AP PF09806.9 CDI86955.1 - 1.5 8.8 21.9 1.9 8.5 21.9 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein CCDC106 PF15794.5 CDI86955.1 - 2.4 7.8 22.5 2.9 7.5 22.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Peptidase_S64 PF08192.11 CDI86955.1 - 3.3 6.1 22.8 3.4 6.0 22.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 RAP1 PF07218.11 CDI86955.1 - 4.8 5.3 8.8 5 5.3 8.8 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DDHD PF02862.17 CDI86955.1 - 5.1 7.2 18.4 5.9 7.0 18.4 1.1 1 0 0 1 1 1 0 DDHD domain HCO3_cotransp PF00955.21 CDI86955.1 - 7.7 5.2 9.2 8.7 5.0 9.2 1.1 1 0 0 1 1 1 0 HCO3- transporter family Sec62 PF03839.16 CDI86955.1 - 7.9 5.9 18.0 9.3 5.7 18.0 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 SR-25 PF10500.9 CDI86956.1 - 1.2e-06 28.4 31.6 0.00061 19.5 10.0 2.2 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein DUF4614 PF15391.6 CDI86956.1 - 0.00032 20.8 21.1 0.0091 16.0 9.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4614) Spt20 PF12090.8 CDI86956.1 - 0.0069 16.0 9.1 0.0069 16.0 9.1 1.7 2 0 0 2 2 2 1 Spt20 family Peptidase_S64 PF08192.11 CDI86956.1 - 0.025 13.1 11.1 0.026 13.0 11.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF508 PF04370.12 CDI86956.1 - 0.025 14.3 5.4 0.025 14.3 5.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF508) Inj_translocase PF16928.5 CDI86956.1 - 0.17 11.3 10.7 0.27 10.7 10.7 1.3 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome TCP PF03634.13 CDI86956.1 - 0.81 10.2 15.3 1.5 9.4 0.9 2.2 2 0 0 2 2 2 0 TCP family transcription factor AF-4 PF05110.13 CDI86956.1 - 0.91 7.5 33.7 0.057 11.5 8.0 2.3 2 0 0 2 2 2 0 AF-4 proto-oncoprotein CCSAP PF15748.5 CDI86956.1 - 0.99 9.5 20.8 2.8 8.1 5.3 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Cwf_Cwc_15 PF04889.12 CDI86956.1 - 1.7 8.3 8.7 3.8 7.2 5.3 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein BAF1_ABF1 PF04684.13 CDI86956.1 - 2.9 6.8 12.8 4.6 6.2 12.8 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor TipE PF16972.5 CDI86956.1 - 4.1 6.5 11.2 0.51 9.5 6.8 1.6 1 1 1 2 2 2 0 Na+ channel auxiliary subunit TipE Pex14_N PF04695.13 CDI86956.1 - 4.6 7.9 34.3 0.067 13.9 11.7 3.0 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1635 PF07795.11 CDI86956.1 - 9.4 6.0 21.3 4.1 7.2 7.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Spt20 PF12090.8 CDI86957.1 - 0.00015 21.5 14.2 0.00015 21.5 14.2 9.5 6 5 2 8 8 8 1 Spt20 family UPF0564 PF10595.9 CDI86957.1 - 0.00061 19.0 2.2 0.00061 19.0 2.2 5.4 6 0 0 6 6 6 2 Uncharacterised protein family UPF0564 DUF755 PF05501.11 CDI86957.1 - 0.0067 16.7 31.6 0.0067 16.7 31.6 16.0 14 3 1 15 15 15 3 Domain of unknown function (DUF755) DUF755 PF05501.11 CDI86959.1 - 0.00012 22.3 15.6 0.00012 22.3 15.6 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF755) AF-4 PF05110.13 CDI86959.1 - 0.00037 18.8 11.7 0.0004 18.7 11.7 1.2 1 0 0 1 1 1 1 AF-4 proto-oncoprotein His_Phos_1 PF00300.22 CDI86959.1 - 0.0048 16.6 3.5 0.0067 16.1 3.5 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) TFIIA PF03153.13 CDI86959.1 - 0.012 15.6 37.5 0.017 15.2 37.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF966 PF06136.13 CDI86959.1 - 0.024 14.4 6.8 0.036 13.8 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF1645 PF07816.11 CDI86959.1 - 0.033 14.8 4.6 0.044 14.4 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Tim54 PF11711.8 CDI86959.1 - 0.06 12.1 3.7 0.018 13.8 1.1 1.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF4718 PF15842.5 CDI86959.1 - 0.069 12.9 3.9 0.11 12.3 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) SPX PF03105.19 CDI86959.1 - 0.11 12.4 11.3 0.15 11.9 11.3 1.2 1 0 0 1 1 1 0 SPX domain Chorion_2 PF03964.15 CDI86959.1 - 0.21 12.5 11.7 0.14 13.0 6.4 2.1 2 0 0 2 2 2 0 Chorion family 2 Plasmodium_Vir PF05795.11 CDI86959.1 - 0.28 10.6 2.1 0.29 10.5 2.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein AUX_IAA PF02309.16 CDI86959.1 - 0.3 10.9 3.3 0.37 10.6 3.3 1.1 1 0 0 1 1 1 0 AUX/IAA family MPM1 PF17234.2 CDI86959.1 - 0.38 11.0 9.0 0.064 13.5 4.6 1.7 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 RskA PF10099.9 CDI86959.1 - 0.63 10.3 18.6 1.3 9.3 18.6 1.5 1 1 0 1 1 1 0 Anti-sigma-K factor rskA PAT1 PF09770.9 CDI86959.1 - 2.2 6.5 21.8 2.9 6.0 21.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.10 CDI86959.1 - 2.5 6.7 37.6 3.2 6.3 37.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal ALMT PF11744.8 CDI86959.1 - 2.7 6.7 4.9 2.9 6.6 4.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 CDI86959.1 - 3.1 6.5 10.9 3.5 6.3 10.9 1.2 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI86959.1 - 3.8 7.5 9.2 5.2 7.0 9.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region UPF0524 PF15823.5 CDI86959.1 - 4.1 6.7 10.1 0.92 8.9 6.2 1.7 2 0 0 2 2 2 0 UPF0524 of C3orf70 BAT2_N PF07001.11 CDI86959.1 - 4.4 7.7 22.1 1.2 9.6 14.4 2.0 2 0 0 2 2 2 0 BAT2 N-terminus DUF2478 PF10649.9 CDI86959.1 - 9.6 5.8 11.2 1.4 8.5 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2478) OAD_gamma PF04277.13 CDI86961.1 - 0.098 13.3 0.2 0.88 10.2 0.0 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Ndc1_Nup PF09531.10 CDI86961.1 - 0.2 10.3 0.9 0.25 10.0 0.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mg_trans_NIPA PF05653.14 CDI86962.1 - 2.7e-05 23.4 1.9 3.8e-05 23.0 1.9 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA Apt1 PF10351.9 CDI86962.1 - 0.34 9.7 4.2 0.44 9.3 4.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF1180 PF06679.12 CDI86962.1 - 2 8.8 9.5 1.7 9.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) DUF2830 PF11125.8 CDI86963.1 - 0.026 14.5 0.3 7.8 6.6 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2830) NTP_transf_2 PF01909.23 CDI86964.1 - 0.04 14.2 1.2 0.043 14.1 0.0 1.7 2 0 0 2 2 2 0 Nucleotidyltransferase domain Dicty_REP PF05086.12 CDI86964.1 - 0.059 11.4 31.3 0.087 10.8 31.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Utp14 PF04615.13 CDI86964.1 - 0.095 11.3 45.8 0.15 10.6 45.8 1.2 1 0 0 1 1 1 0 Utp14 protein Tim54 PF11711.8 CDI86964.1 - 1.3 7.8 38.7 0.22 10.3 23.7 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 CRT10 PF08728.10 CDI86964.1 - 3.5 5.7 27.9 4.8 5.2 27.9 1.1 1 0 0 1 1 1 0 CRT10 Gti1_Pac2 PF09729.9 CDI86964.1 - 4.6 7.3 52.5 0.23 11.5 23.0 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family RR_TM4-6 PF06459.12 CDI86964.1 - 5.2 6.8 50.5 2.1 8.1 4.1 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 FGF-BP1 PF06473.12 CDI86964.1 - 5.4 6.8 45.2 1.1 9.1 29.8 2.2 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) PTPRCAP PF15713.5 CDI86964.1 - 6.6 7.0 45.2 0.84 9.9 29.8 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DAG_kinase_N PF14513.6 CDI86964.1 - 7.2 6.8 50.8 9 6.5 12.0 2.1 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus CDC45 PF02724.14 CDI86964.1 - 9.9 4.3 50.5 0.97 7.6 28.9 2.0 2 0 0 2 2 2 0 CDC45-like protein RBFA PF02033.18 CDI86965.1 - 1.5e-12 47.9 0.1 3.6e-12 46.7 0.0 1.7 2 0 0 2 2 2 1 Ribosome-binding factor A Nab1 PF04902.12 CDI86966.1 - 0.16 12.4 1.3 0.33 11.3 1.3 1.6 1 1 0 1 1 1 0 Conserved region in Nab1 Ribosomal_60s PF00428.19 CDI86967.1 - 0.033 14.8 5.9 0.033 14.8 5.9 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein NUDIX PF00293.28 CDI86967.1 - 0.11 12.6 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 NUDIX domain DUF1635 PF07795.11 CDI86968.1 - 0.0042 17.0 20.8 0.0042 17.0 20.8 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1635) Head-tail_con PF12236.8 CDI86968.1 - 0.45 8.9 11.2 0.15 10.4 7.9 1.6 1 1 1 2 2 2 0 Bacteriophage head to tail connecting protein MRP-S31 PF15433.6 CDI86968.1 - 0.45 10.1 10.0 0.54 9.9 10.0 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 ANAPC1 PF12859.7 CDI86968.1 - 5.6 7.5 13.3 1.5 9.4 4.9 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 RNA_lig_T4_1 PF09511.10 CDI86970.1 - 0.0096 15.8 0.4 0.033 14.0 0.1 2.0 2 0 0 2 2 2 1 RNA ligase AAA_18 PF13238.6 CDI86970.1 - 1.2 9.7 4.8 18 5.9 0.1 3.2 3 0 0 3 3 3 0 AAA domain KH_1 PF00013.29 CDI86971.1 - 4.8e-07 29.5 0.0 1.3e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 CDI86971.1 - 0.16 11.8 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 KH domain CrgA PF06781.12 CDI86971.1 - 0.23 11.6 0.1 0.23 11.6 0.1 3.0 3 0 0 3 3 3 0 Cell division protein CrgA DUF2722 PF10846.8 CDI86972.1 - 0.00017 20.7 2.7 0.00017 20.7 2.7 3.8 2 1 2 4 4 2 1 Protein of unknown function (DUF2722) SR-25 PF10500.9 CDI86972.1 - 0.0012 18.5 60.0 0.015 14.9 10.6 4.1 4 0 0 4 4 4 3 Nuclear RNA-splicing-associated protein ORC6 PF05460.13 CDI86972.1 - 0.0025 17.2 18.7 0.0025 17.2 18.7 2.7 3 0 0 3 3 3 1 Origin recognition complex subunit 6 (ORC6) Med15 PF09606.10 CDI86972.1 - 0.0028 16.5 3.7 0.0028 16.5 3.7 2.8 3 1 0 3 3 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.8 CDI86972.1 - 0.0035 17.0 7.3 0.0035 17.0 7.3 3.6 3 1 1 4 4 2 1 Spt20 family Lin-8 PF03353.15 CDI86972.1 - 0.0053 16.4 18.0 0.0053 16.4 18.0 2.7 2 1 0 2 2 2 1 Ras-mediated vulval-induction antagonist Apt1 PF10351.9 CDI86972.1 - 0.037 12.9 23.8 0.74 8.6 16.7 2.4 2 0 0 2 2 2 0 Golgi-body localisation protein domain Ecl1 PF12855.7 CDI86972.1 - 0.06 14.5 30.7 0.18 13.0 19.5 3.1 3 0 0 3 3 3 0 ECL1/2/3 zinc binding proteins DAGK_cat PF00781.24 CDI86972.1 - 0.079 12.6 1.5 0.17 11.5 0.0 2.3 3 0 0 3 3 3 0 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 CDI86972.1 - 0.11 11.6 0.0 0.29 10.3 0.0 1.7 1 0 0 1 1 1 0 ATP-NAD kinase SpoIIP PF07454.11 CDI86972.1 - 2.1 7.7 17.8 1.5 8.2 10.0 2.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) CCSAP PF15748.5 CDI86972.1 - 4.7 7.3 45.9 0.45 10.7 19.1 4.2 4 0 0 4 4 4 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 CDI86972.1 - 4.7 6.1 16.3 1.2 8.1 9.5 2.3 2 0 0 2 2 2 0 Solute carrier family 12 DUF4667 PF15700.5 CDI86972.1 - 5.6 7.0 47.3 0.072 13.2 2.9 3.4 2 2 1 3 3 3 0 Domain of unknown function (DUF4667) DUF1772 PF08592.11 CDI86975.1 - 0.012 15.9 4.8 0.019 15.3 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Auxin_canalis PF05703.11 CDI86975.1 - 1.2 9.0 27.3 0.071 13.0 21.0 1.8 2 0 0 2 2 2 0 Auxin canalisation Pyrid_oxidase_2 PF13883.6 CDI86975.1 - 3 7.8 7.0 0.24 11.3 1.6 1.8 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase Ndc1_Nup PF09531.10 CDI86975.1 - 5.3 5.6 19.8 7.4 5.1 19.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HGTP_anticodon2 PF12745.7 CDI86975.1 - 7.5 6.0 21.9 0.71 9.3 13.7 2.1 2 0 0 2 2 2 0 Anticodon binding domain of tRNAs DUF4551 PF15087.6 CDI86976.1 - 0.19 10.5 16.7 0.2 10.5 16.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) eIF-3_zeta PF05091.12 CDI86976.1 - 1.7 7.5 24.6 2.1 7.2 24.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Hid1 PF12722.7 CDI86976.1 - 2.6 6.1 21.5 2.5 6.1 21.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2722 PF10846.8 CDI86977.1 - 5e-06 25.7 6.0 5e-06 25.7 6.0 6.0 2 1 2 4 4 4 1 Protein of unknown function (DUF2722) DUF4834 PF16118.5 CDI86977.1 - 3.5e-05 24.7 5.7 3.5e-05 24.7 5.7 5.6 3 1 1 4 4 4 1 Domain of unknown function (DUF4834) Tetraspanin PF00335.20 CDI86977.1 - 0.00024 20.9 0.1 0.00024 20.9 0.1 2.2 3 0 0 3 3 3 1 Tetraspanin family CBP_BcsG PF11658.8 CDI86977.1 - 0.00036 19.1 3.7 0.00036 19.1 3.7 4.1 2 1 2 4 4 4 1 Cellulose biosynthesis protein BcsG EphA2_TM PF14575.6 CDI86977.1 - 0.0018 19.1 2.6 0.0018 19.1 2.6 5.1 2 1 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain FAM176 PF14851.6 CDI86977.1 - 0.0031 17.2 0.7 0.0031 17.2 0.7 4.5 2 1 2 4 4 4 1 FAM176 family O-antigen_lig PF13425.6 CDI86977.1 - 0.0035 16.2 0.2 0.0035 16.2 0.2 2.8 2 1 1 3 3 3 1 O-antigen ligase like membrane protein DUF5305 PF17231.2 CDI86977.1 - 0.22 10.9 2.9 7.4 5.9 1.2 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5305) Ac76 PF05814.11 CDI86977.1 - 0.91 9.6 2.9 2.3 8.3 2.9 1.7 1 0 0 1 1 1 0 Orf76 (Ac76) DUF4079 PF13301.6 CDI86977.1 - 1.3 9.2 0.0 1.3 9.2 0.0 4.0 4 1 0 4 4 4 0 Protein of unknown function (DUF4079) SR-25 PF10500.9 CDI86978.1 - 0.0019 17.8 4.5 0.0019 17.8 4.5 9.8 7 3 2 9 9 9 3 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI86978.1 - 0.1 11.5 0.0 0.1 11.5 0.0 10.0 6 3 2 9 9 9 0 Protein of unknown function (DUF2722) LANC_like PF05147.13 CDI86979.1 - 0.28 9.7 3.3 0.74 8.3 3.3 1.7 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein Presenilin PF01080.17 CDI86981.1 - 0.0029 16.4 22.6 0.0037 16.1 22.6 1.1 1 0 0 1 1 1 1 Presenilin DUF572 PF04502.13 CDI86981.1 - 0.0085 15.8 18.1 0.01 15.5 18.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) SWI-SNF_Ssr4 PF08549.10 CDI86981.1 - 0.027 13.1 21.3 0.034 12.8 21.3 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) CNDH2_C PF16858.5 CDI86981.1 - 0.036 13.9 25.2 0.053 13.4 25.2 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Neur_chan_memb PF02932.16 CDI86981.1 - 0.05 13.7 13.9 0.068 13.2 13.9 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4776 PF16003.5 CDI86981.1 - 0.063 12.3 19.7 0.075 12.0 19.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) PA26 PF04636.13 CDI86981.1 - 0.25 10.2 16.1 0.34 9.8 16.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) GET2 PF08690.10 CDI86981.1 - 0.36 10.4 24.6 0.4 10.3 24.6 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 SLC12 PF03522.15 CDI86981.1 - 0.44 9.5 22.5 0.68 8.9 22.5 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Exonuc_VII_L PF02601.15 CDI86981.1 - 1.9 8.0 25.1 2.3 7.7 25.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CCSAP PF15748.5 CDI86981.1 - 2.1 8.4 25.9 3.2 7.8 25.9 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Piezo_RRas_bdg PF12166.8 CDI86981.1 - 2.1 7.5 17.3 2.7 7.2 17.3 1.1 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain UNC-79 PF14776.6 CDI86981.1 - 2.4 6.8 11.9 3.2 6.4 11.9 1.2 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 Ndc1_Nup PF09531.10 CDI86981.1 - 3.1 6.4 21.9 3.6 6.2 21.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GREB1 PF15782.5 CDI86981.1 - 3.5 4.6 20.3 4 4.4 20.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4569 PF15133.6 CDI86981.1 - 3.6 7.2 24.4 6.6 6.4 24.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) BNR_3 PF13859.6 CDI86981.1 - 6.5 5.9 10.8 8.6 5.5 10.8 1.1 1 0 0 1 1 1 0 BNR repeat-like domain DUF3141 PF11339.8 CDI86982.1 - 3.6 5.9 12.0 5.2 5.4 12.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) Ribosomal_60s PF00428.19 CDI86983.1 - 0.19 12.4 5.5 1.4 9.6 5.5 2.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein 2-oxoacid_dh PF00198.23 CDI86984.1 - 2.1e-65 220.4 0.3 5.4e-25 88.2 0.0 3.0 1 1 2 3 3 3 3 2-oxoacid dehydrogenases acyltransferase (catalytic domain) V_ATPase_I PF01496.19 CDI86985.1 - 0.041 11.8 14.7 0.047 11.6 14.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SLC12 PF03522.15 CDI86985.1 - 0.084 11.9 9.8 0.085 11.9 9.8 1.4 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI86985.1 - 0.092 11.0 32.7 0.097 10.9 32.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ADP_ribosyl_GH PF03747.14 CDI86985.1 - 0.093 12.4 10.8 0.12 12.1 10.8 1.2 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase Peptidase_S49_N PF08496.10 CDI86985.1 - 0.11 12.5 14.7 0.18 11.8 14.7 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PIEZO PF15917.5 CDI86985.1 - 0.16 11.4 19.4 0.24 10.8 19.4 1.3 1 0 0 1 1 1 0 Piezo ZYG-11_interact PF05884.12 CDI86985.1 - 0.19 11.1 13.2 0.34 10.3 13.2 1.4 1 0 0 1 1 1 0 Interactor of ZYG-11 Exonuc_VII_L PF02601.15 CDI86985.1 - 0.45 10.0 28.4 0.57 9.7 28.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Z1 PF10593.9 CDI86985.1 - 0.52 9.8 12.2 0.77 9.2 12.2 1.2 1 0 0 1 1 1 0 Z1 domain Draxin PF15550.6 CDI86985.1 - 0.58 10.0 17.0 0.95 9.3 17.0 1.3 1 0 0 1 1 1 0 Draxin LMBR1 PF04791.16 CDI86985.1 - 0.62 8.9 5.1 0.64 8.9 5.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Sec62 PF03839.16 CDI86985.1 - 0.68 9.4 9.3 1.1 8.8 9.3 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Lin-8 PF03353.15 CDI86985.1 - 0.83 9.2 31.7 0.05 13.2 21.9 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Nop53 PF07767.11 CDI86985.1 - 1 8.7 28.5 1.7 7.9 28.5 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) MAJIN PF15077.6 CDI86985.1 - 1.8 8.3 12.7 3.6 7.3 12.7 1.5 1 0 0 1 1 1 0 Membrane-anchored junction protein ALMT PF11744.8 CDI86985.1 - 2 7.2 14.6 2.6 6.8 14.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter FapA PF03961.13 CDI86985.1 - 2.4 6.7 12.3 3.1 6.3 12.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A eIF-3_zeta PF05091.12 CDI86985.1 - 3.1 6.7 19.6 4 6.3 19.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3533 PF12051.8 CDI86985.1 - 3.2 6.6 12.3 4 6.3 12.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) 5_nucleotid PF05761.14 CDI86985.1 - 3.9 6.3 12.0 4.9 5.9 12.0 1.1 1 0 0 1 1 1 0 5' nucleotidase family Zea_mays_MuDR PF05928.11 CDI86985.1 - 4.1 7.0 13.6 5.9 6.5 13.6 1.2 1 0 0 1 1 1 0 Zea mays MURB-like protein (MuDR) YjbH PF06082.11 CDI86985.1 - 6.4 5.5 17.6 7.8 5.2 17.6 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Fumble PF03630.14 CDI86987.1 - 3.1e-71 240.2 0.1 5.4e-66 223.0 0.0 2.4 2 1 0 2 2 2 2 Fumble DUF4658 PF15555.6 CDI86987.1 - 0.2 11.8 2.3 0.67 10.1 2.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) TFIIA PF03153.13 CDI86987.1 - 2.3 8.1 31.3 0.27 11.2 13.0 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI86987.1 - 3 8.0 20.8 2.9 8.0 9.3 3.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF5447 PF17525.2 CDI86990.1 - 0.011 16.1 0.0 0.039 14.4 0.0 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5447) Spt20 PF12090.8 CDI86993.1 - 4.8e-05 23.1 8.5 5.1e-05 23.0 8.5 1.1 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 CDI86993.1 - 0.015 15.3 14.3 0.016 15.2 14.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF5131 PF07505.11 CDI86993.1 - 0.044 13.2 1.7 0.05 13.0 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF5131) CSRNP_N PF16019.5 CDI86993.1 - 0.26 11.2 5.5 0.35 10.8 5.5 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Pex14_N PF04695.13 CDI86993.1 - 2.7 8.7 20.0 0.065 13.9 13.0 1.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2722 PF10846.8 CDI86994.1 - 0.027 13.4 0.0 0.027 13.4 0.0 11.1 10 2 0 10 10 10 0 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI86994.1 - 0.2 11.8 0.1 0.041 14.0 6.8 15.8 12 4 1 13 13 13 0 Unstructured region C-term to UIM in Ataxin3 Tir_receptor_N PF07490.11 CDI86995.1 - 0.00076 19.4 2.7 0.00076 19.4 2.7 2.6 3 0 0 3 3 3 1 Translocated intimin receptor (Tir) N-terminus CbiM PF01891.16 CDI86995.1 - 0.018 14.9 4.3 0.86 9.4 0.0 2.2 2 0 0 2 2 2 0 Cobalt uptake substrate-specific transmembrane region AAA_23 PF13476.6 CDI86995.1 - 0.11 12.9 24.6 0.45 11.0 14.0 2.1 2 0 0 2 2 2 0 AAA domain DUF4148 PF13663.6 CDI86995.1 - 0.12 12.6 0.0 0.12 12.6 0.0 4.6 3 2 0 3 3 3 0 Domain of unknown function (DUF4148) LRR19-TM PF15176.6 CDI86995.1 - 0.25 11.3 4.4 0.6 10.1 0.1 2.5 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain RskA PF10099.9 CDI86995.1 - 0.25 11.6 50.8 0.023 15.0 8.5 3.3 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF1772 PF08592.11 CDI86995.1 - 1.5 9.1 12.4 4.2 7.7 0.2 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF1772) DUF572 PF04502.13 CDI86995.1 - 3.6 7.1 34.8 5.1 6.6 34.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) RskA PF10099.9 CDI86996.1 - 0.042 14.2 0.1 0.042 14.2 0.1 14.1 5 4 6 12 12 12 0 Anti-sigma-K factor rskA eIF-3c_N PF05470.12 CDI86997.1 - 7.7e-129 430.7 6.5 1.3e-128 430.0 6.5 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 CDI86997.1 - 1.4e-11 44.8 0.3 8.1e-11 42.4 0.0 2.6 2 0 0 2 2 2 1 PCI domain DNA_photolyase PF00875.18 CDI86998.1 - 4e-10 39.9 0.7 5.5e-10 39.5 0.7 1.2 1 0 0 1 1 1 1 DNA photolyase Myosin_head PF00063.21 CDI86999.1 - 1.8e-24 86.0 0.0 2e-24 85.9 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) eIF-3_zeta PF05091.12 CDI87001.1 - 0.0044 16.1 7.3 0.0044 16.1 7.3 3.5 2 1 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RskA PF10099.9 CDI87001.1 - 0.017 15.4 4.4 0.017 15.4 4.4 6.8 1 1 4 5 5 5 0 Anti-sigma-K factor rskA Peroxin-3 PF04882.12 CDI87001.1 - 2.3 7.1 66.4 0.005 15.9 32.7 4.2 1 1 1 2 2 2 0 Peroxin-3 ETRAMP PF09716.10 CDI87001.1 - 8.1 6.6 12.5 10 6.2 0.1 4.4 4 0 0 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) NPR3 PF03666.13 CDI87002.1 - 0.00095 18.1 9.6 0.00095 18.1 9.6 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 Serinc PF03348.15 CDI87002.1 - 0.0047 15.9 9.3 0.0055 15.7 9.3 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) SID-1_RNA_chan PF13965.6 CDI87002.1 - 0.01 14.3 4.9 0.012 14.1 4.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PBP1_TM PF14812.6 CDI87002.1 - 0.016 15.6 4.4 0.022 15.1 4.4 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CLN3 PF02487.17 CDI87002.1 - 0.036 13.1 5.9 0.043 12.9 5.9 1.2 1 0 0 1 1 1 0 CLN3 protein CDC45 PF02724.14 CDI87002.1 - 0.046 12.0 10.9 0.049 11.9 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2052 PF09747.9 CDI87002.1 - 0.095 12.8 13.7 0.11 12.6 13.7 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) HCO3_cotransp PF00955.21 CDI87002.1 - 0.1 11.4 3.1 0.12 11.2 3.1 1.1 1 0 0 1 1 1 0 HCO3- transporter family SARAF PF06682.12 CDI87002.1 - 0.1 12.2 13.1 0.12 11.9 13.1 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis O-antigen_lig PF13425.6 CDI87002.1 - 0.17 10.7 1.8 0.19 10.4 1.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Med15 PF09606.10 CDI87002.1 - 0.26 9.9 36.8 0.33 9.6 36.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF913 PF06025.12 CDI87002.1 - 0.32 9.9 10.2 0.38 9.7 10.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TFIIA PF03153.13 CDI87002.1 - 0.34 10.9 40.6 0.45 10.5 40.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop53 PF07767.11 CDI87002.1 - 0.37 10.1 20.9 0.45 9.8 20.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SPX PF03105.19 CDI87002.1 - 0.38 10.6 19.2 0.48 10.3 19.2 1.0 1 0 0 1 1 1 0 SPX domain Neur_chan_memb PF02932.16 CDI87002.1 - 0.38 10.8 9.9 0.47 10.5 9.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region V_ATPase_I PF01496.19 CDI87002.1 - 0.39 8.6 10.9 0.42 8.5 10.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SelP_N PF04592.14 CDI87002.1 - 0.52 9.7 16.6 0.75 9.2 16.6 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SprA-related PF12118.8 CDI87002.1 - 0.54 9.3 40.5 0.93 8.6 40.5 1.3 1 0 0 1 1 1 0 SprA-related family Macoilin PF09726.9 CDI87002.1 - 0.6 8.6 16.7 0.79 8.2 16.7 1.2 1 0 0 1 1 1 0 Macoilin family CSG2 PF16965.5 CDI87002.1 - 0.65 8.9 8.0 0.75 8.7 8.0 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator BAF1_ABF1 PF04684.13 CDI87002.1 - 0.75 8.8 23.3 1.4 7.9 23.3 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Afi1 PF07792.12 CDI87002.1 - 0.78 10.2 11.4 1.1 9.7 11.4 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking SLC12 PF03522.15 CDI87002.1 - 0.91 8.5 14.7 1 8.3 14.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PPP4R2 PF09184.11 CDI87002.1 - 0.98 8.9 10.0 1 8.9 10.0 1.1 1 0 0 1 1 1 0 PPP4R2 Smg8_Smg9 PF10220.9 CDI87002.1 - 1.2 7.3 16.8 1.3 7.2 16.8 1.0 1 0 0 1 1 1 0 Smg8_Smg9 eIF-3_zeta PF05091.12 CDI87002.1 - 1.4 7.8 19.1 1.7 7.5 19.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EMC3_TMCO1 PF01956.16 CDI87002.1 - 1.6 8.4 5.8 1.9 8.2 5.8 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Peroxin-3 PF04882.12 CDI87002.1 - 1.7 7.5 19.9 2.4 7.0 19.9 1.3 1 0 0 1 1 1 0 Peroxin-3 Apt1 PF10351.9 CDI87002.1 - 2.2 7.1 14.3 2.3 7.0 14.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF3112 PF11309.8 CDI87002.1 - 2.7 7.4 5.8 3.7 7.0 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) DUF4551 PF15087.6 CDI87002.1 - 3.8 6.2 17.1 4.5 6.0 17.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Peptidase_S49_N PF08496.10 CDI87002.1 - 4 7.5 16.0 7.2 6.6 15.7 1.7 1 1 0 1 1 1 0 Peptidase family S49 N-terminal Hamartin PF04388.12 CDI87002.1 - 4.4 5.8 19.7 5.3 5.6 19.7 1.0 1 0 0 1 1 1 0 Hamartin protein Myc_N PF01056.18 CDI87002.1 - 4.9 6.9 16.7 6.5 6.5 16.7 1.1 1 0 0 1 1 1 0 Myc amino-terminal region DUF572 PF04502.13 CDI87002.1 - 5 6.6 19.7 6.4 6.3 19.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Endomucin PF07010.12 CDI87002.1 - 5.1 7.0 23.0 7.1 6.5 23.0 1.3 1 0 0 1 1 1 0 Endomucin PAT1 PF09770.9 CDI87002.1 - 5.4 5.1 28.6 6.4 4.9 28.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SART-1 PF03343.13 CDI87002.1 - 5.7 5.4 21.6 6.8 5.1 21.6 1.0 1 0 0 1 1 1 0 SART-1 family CDC27 PF09507.10 CDI87002.1 - 8 5.7 25.3 11 5.3 25.3 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Raftlin PF15250.6 CDI87002.1 - 8.7 5.0 16.2 9.6 4.8 16.2 1.1 1 0 0 1 1 1 0 Raftlin Hid1 PF12722.7 CDI87002.1 - 8.8 4.3 19.1 9.7 4.2 19.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ALMT PF11744.8 CDI87002.1 - 9.3 5.0 13.7 11 4.7 13.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CD20 PF04103.15 CDI87002.1 - 9.8 6.2 12.0 9.2e+02 -0.2 12.0 2.1 1 1 0 1 1 1 0 CD20-like family RskA PF10099.9 CDI87003.1 - 0.00067 20.0 15.5 0.001 19.4 15.5 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF2298 PF10060.9 CDI87003.1 - 0.04 12.6 1.4 0.055 12.2 1.4 1.1 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) Suf PF05843.14 CDI87004.1 - 0.046 13.7 19.3 0.087 12.8 19.3 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Macoilin PF09726.9 CDI87004.1 - 0.11 11.0 27.8 0.13 10.8 27.8 1.1 1 0 0 1 1 1 0 Macoilin family SARAF PF06682.12 CDI87004.1 - 0.4 10.3 13.8 0.7 9.5 13.8 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis MMR1 PF08505.10 CDI87004.1 - 0.59 10.4 26.2 0.81 9.9 26.2 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Hamartin PF04388.12 CDI87004.1 - 1.7 7.2 18.2 1.9 7.0 18.2 1.1 1 0 0 1 1 1 0 Hamartin protein RIFIN PF02009.16 CDI87004.1 - 2.3 8.0 18.7 3.5 7.4 18.7 1.4 1 0 0 1 1 1 0 Rifin SOBP PF15279.6 CDI87004.1 - 2.8 8.5 20.6 3.4 8.2 20.6 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein CDK5_activator PF03261.15 CDI87004.1 - 2.8 7.4 14.7 3.4 7.1 14.7 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein SWI-SNF_Ssr4 PF08549.10 CDI87004.1 - 2.9 6.4 27.9 3.9 6.0 27.9 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) CCSAP PF15748.5 CDI87004.1 - 3.5 7.7 25.7 4.3 7.4 25.7 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Serinc PF03348.15 CDI87004.1 - 8.7 5.1 11.2 12 4.7 11.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Med3 PF11593.8 CDI87005.1 - 0.00028 20.2 12.1 0.00028 20.2 12.1 8.3 4 3 3 7 7 7 1 Mediator complex subunit 3 fungal Dehydrin PF00257.19 CDI87005.1 - 0.0062 17.1 3.0 0.0062 17.1 3.0 11.1 3 2 7 10 10 10 1 Dehydrin DUF755 PF05501.11 CDI87005.1 - 0.0079 16.5 14.9 0.0079 16.5 14.9 6.9 3 2 3 6 6 6 1 Domain of unknown function (DUF755) RAP1 PF07218.11 CDI87006.1 - 3.2 5.9 8.4 4.6 5.4 8.4 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RskA PF10099.9 CDI87007.1 - 0.0024 18.2 0.7 0.0024 18.2 0.7 8.5 5 3 1 7 7 7 4 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI87007.1 - 0.017 15.2 1.2 0.017 15.2 1.2 13.2 10 3 1 11 11 11 0 Unstructured region C-term to UIM in Ataxin3 DUF719 PF05334.13 CDI87007.1 - 0.024 14.8 0.7 0.024 14.8 0.7 9.1 3 3 3 6 6 6 0 Protein of unknown function (DUF719) Exonuc_VII_L PF02601.15 CDI87008.1 - 1.7e-05 24.6 18.7 1.7e-05 24.6 18.7 3.5 2 1 0 3 3 3 1 Exonuclease VII, large subunit Spt20 PF12090.8 CDI87008.1 - 2.1e-05 24.3 12.4 2.1e-05 24.3 12.4 4.3 2 1 0 2 2 2 1 Spt20 family DUF2722 PF10846.8 CDI87008.1 - 0.00024 20.2 9.0 0.00024 20.2 9.0 4.2 2 1 2 4 4 4 1 Protein of unknown function (DUF2722) DUF1644 PF07800.12 CDI87008.1 - 0.012 15.6 0.4 0.012 15.6 0.4 3.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1644) DUF5523 PF17661.1 CDI87008.1 - 2.6 7.7 44.9 1.1 8.9 1.6 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) SLC12 PF03522.15 CDI87008.1 - 6.3 5.7 54.9 1.2 8.1 2.4 2.1 2 0 0 2 2 2 0 Solute carrier family 12 DUF2802 PF10975.8 CDI87009.1 - 0.059 13.5 4.9 0.12 12.5 4.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) SUIM_assoc PF16619.5 CDI87009.1 - 0.13 12.3 9.6 0.28 11.3 9.6 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI87009.1 - 0.53 9.9 7.7 0.85 9.2 7.7 1.3 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 CDI87009.1 - 3.9 6.5 5.2 7.4 5.6 5.2 1.4 1 0 0 1 1 1 0 Drosophila roughex protein Sporozoite_P67 PF05642.11 CDI87009.1 - 6.4 4.7 6.3 6.3 4.8 6.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TFIIA PF03153.13 CDI87010.1 - 0.0032 17.5 31.6 0.0041 17.2 31.6 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 CDI87010.1 - 0.028 13.4 13.4 0.03 13.3 13.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4407 PF14362.6 CDI87010.1 - 0.034 13.5 19.9 0.045 13.1 19.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RskA PF10099.9 CDI87010.1 - 0.1 12.9 21.5 0.61 10.4 21.5 2.0 1 1 0 1 1 1 0 Anti-sigma-K factor rskA APH PF01636.23 CDI87010.1 - 0.14 12.1 5.5 0.19 11.6 5.5 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PAT1 PF09770.9 CDI87010.1 - 0.26 9.5 19.2 0.26 9.5 19.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hamartin PF04388.12 CDI87010.1 - 0.43 9.2 16.1 0.57 8.8 16.1 1.0 1 0 0 1 1 1 0 Hamartin protein SID-1_RNA_chan PF13965.6 CDI87010.1 - 1.7 6.9 2.5 2.3 6.5 2.5 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 LMBR1 PF04791.16 CDI87010.1 - 2.1 7.1 4.5 2.1 7.1 4.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1980 PF09323.10 CDI87010.1 - 7.3 6.5 8.9 1 9.3 4.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Actin PF00022.19 CDI87012.1 - 2.1e-05 23.3 0.0 0.0079 14.8 0.0 2.7 3 0 0 3 3 3 2 Actin TFIIA PF03153.13 CDI87012.1 - 0.058 13.4 3.4 0.099 12.6 3.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DREPP PF05558.12 CDI87012.1 - 0.081 12.8 2.8 0.13 12.1 2.8 1.2 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide RskA PF10099.9 CDI87012.1 - 0.086 13.1 25.2 0.16 12.3 25.2 1.4 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Hamartin PF04388.12 CDI87012.1 - 0.52 8.9 6.4 0.82 8.3 6.4 1.4 1 1 0 1 1 1 0 Hamartin protein AbLIM_anchor PF16182.5 CDI87012.1 - 9.4 6.0 10.1 3.7 7.3 6.8 1.8 2 0 0 2 2 2 0 Putative adherens-junction anchoring region of AbLIM SR-25 PF10500.9 CDI87013.1 - 5.6e-06 26.1 17.5 5.6e-06 26.1 17.5 4.4 4 0 0 4 4 4 1 Nuclear RNA-splicing-associated protein Lin-8 PF03353.15 CDI87013.1 - 6.2 6.3 56.1 1.7 8.1 13.1 3.3 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist RNA_pol_Rpb1_R PF05001.13 CDI87014.1 - 5.6e-09 35.9 225.0 0.0024 18.1 14.0 17.3 11 4 7 19 19 19 16 RNA polymerase Rpb1 C-terminal repeat PIG-H PF10181.9 CDI87015.1 - 2.8e-10 39.9 0.6 5.8e-10 38.9 0.6 1.6 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component DUF3527 PF12043.8 CDI87015.1 - 0.14 11.7 19.0 0.19 11.3 19.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) EIF4E-T PF10477.9 CDI87015.1 - 1 8.1 39.0 1.2 7.8 39.0 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Tic110 PF16940.5 CDI87015.1 - 1 7.8 20.1 0.27 9.7 15.3 2.0 2 0 0 2 2 2 0 Chloroplast envelope transporter LAP1C PF05609.12 CDI87015.1 - 1.3 8.0 31.6 1.7 7.7 31.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) EFTUD2 PF16004.5 CDI87015.1 - 1.4 9.6 25.8 0.31 11.6 2.4 2.4 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus OATP PF03137.20 CDI87015.1 - 1.4 7.1 14.5 1.9 6.7 6.8 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Caldesmon PF02029.15 CDI87015.1 - 2.3 6.9 33.4 3.4 6.3 33.4 1.3 1 0 0 1 1 1 0 Caldesmon DUF966 PF06136.13 CDI87015.1 - 2.6 7.7 24.1 3.8 7.1 24.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Nucleoside_tran PF01733.18 CDI87015.1 - 4 6.7 6.6 3.6 6.9 1.6 2.1 2 0 0 2 2 2 0 Nucleoside transporter DcuA_DcuB PF03605.14 CDI87015.1 - 4.3 6.1 18.6 10 4.9 0.3 2.2 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter DcuC PF03606.15 CDI87015.1 - 5.5 5.3 13.3 1.7 7.0 7.7 2.1 2 0 0 2 2 2 0 C4-dicarboxylate anaerobic carrier PAT1 PF09770.9 CDI87015.1 - 6.9 4.8 55.3 11 4.1 55.3 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hid1 PF12722.7 CDI87015.1 - 9.3 4.2 28.4 13 3.7 28.4 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CBP_BcsG PF11658.8 CDI87016.1 - 0.014 13.8 4.8 0.017 13.5 4.8 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG V_ATPase_I PF01496.19 CDI87016.1 - 0.019 12.9 4.3 0.021 12.8 4.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3592 PF12158.8 CDI87016.1 - 0.12 12.4 0.7 0.17 12.0 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3592) SID-1_RNA_chan PF13965.6 CDI87016.1 - 0.13 10.7 0.3 0.13 10.6 0.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EOS1 PF12326.8 CDI87016.1 - 0.19 11.7 0.8 0.23 11.4 0.8 1.2 1 0 0 1 1 1 0 N-glycosylation protein DUF4131 PF13567.6 CDI87016.1 - 4.1 7.0 13.2 9.8 5.8 13.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) GET2 PF08690.10 CDI87016.1 - 4.6 6.8 13.5 5.8 6.5 13.5 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Gastrin PF00918.17 CDI87016.1 - 7.2 7.6 13.0 9.6 7.2 13.0 1.2 1 0 0 1 1 1 0 Gastrin/cholecystokinin family DUF2722 PF10846.8 CDI87017.1 - 0.0011 18.0 13.5 0.0011 18.0 13.5 3.9 2 1 1 4 4 4 1 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI87017.1 - 0.012 15.6 0.0 0.012 15.6 0.0 7.0 5 3 1 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 Ferlin_C PF16165.5 CDI87017.1 - 0.1 12.6 0.1 0.34 10.9 0.0 1.8 2 0 0 2 2 2 0 Ferlin C-terminus DUF5523 PF17661.1 CDI87017.1 - 0.23 11.1 11.8 1.8 8.2 1.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5523) LD_cluster2 PF18163.1 CDI87017.1 - 0.86 9.1 5.4 0.79 9.2 0.9 2.1 2 0 0 2 2 2 0 SLOG cluster2 TrbI_Ftype PF09677.10 CDI87017.1 - 2 8.8 8.4 0.13 12.5 2.0 2.4 2 0 0 2 2 2 0 Type-F conjugative transfer system protein (TrbI_Ftype) Caldesmon PF02029.15 CDI87017.1 - 3.4 6.3 23.8 0.23 10.2 10.7 2.2 2 0 0 2 2 2 0 Caldesmon Band_3_cyto PF07565.13 CDI87017.1 - 8.5 6.1 15.4 1.1 8.9 1.4 2.5 3 0 0 3 3 3 0 Band 3 cytoplasmic domain TMEM82 PF15816.5 CDI87020.1 - 0.00038 19.5 0.9 0.00061 18.9 0.9 1.2 1 0 0 1 1 1 1 Transmembrane protein 82 DUF4834 PF16118.5 CDI87020.1 - 0.00057 20.8 0.7 0.00057 20.8 0.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) K_channel_TID PF07941.11 CDI87020.1 - 0.0014 19.0 8.8 0.0014 19.0 8.8 9.3 5 2 2 7 7 3 1 Potassium channel Kv1.4 tandem inactivation domain DUF2722 PF10846.8 CDI87020.1 - 0.0042 16.1 5.8 0.0042 16.1 5.8 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Tmemb_9 PF05434.11 CDI87020.1 - 0.06 13.2 0.9 0.11 12.3 0.9 1.4 1 0 0 1 1 1 0 TMEM9 Pex24p PF06398.11 CDI87020.1 - 0.15 11.0 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin TMEM208_SND2 PF05620.11 CDI87020.1 - 0.16 11.7 1.1 0.39 10.5 1.1 1.5 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DUF2227 PF09988.9 CDI87020.1 - 0.28 11.1 0.6 0.55 10.1 0.6 1.5 1 0 0 1 1 1 0 Uncharacterized metal-binding protein (DUF2227) SLD3 PF08639.10 CDI87020.1 - 0.64 8.7 5.8 1.1 7.9 5.8 1.3 1 0 0 1 1 1 0 DNA replication regulator SLD3 Spt20 PF12090.8 CDI87020.1 - 1.4 8.4 24.4 5.3 6.6 16.7 2.2 2 0 0 2 2 2 0 Spt20 family V_ATPase_I PF01496.19 CDI87020.1 - 1.8 6.4 3.2 3.2 5.6 3.2 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family KCNQ2_u3 PF16642.5 CDI87020.1 - 9.5 7.3 9.3 1.6 9.7 0.3 2.8 2 0 0 2 2 2 0 Unstructured region on Potassium channel subunit alpha KvLQT2 Caldesmon PF02029.15 CDI87021.1 - 0.001 18.0 36.9 0.001 18.0 36.9 5.7 6 0 0 6 6 6 3 Caldesmon DREPP PF05558.12 CDI87021.1 - 0.0046 16.9 3.1 0.0046 16.9 3.1 6.7 7 1 1 8 8 8 1 DREPP plasma membrane polypeptide PPP4R2 PF09184.11 CDI87022.1 - 0.00096 18.8 40.0 0.0012 18.5 40.0 1.2 1 0 0 1 1 1 1 PPP4R2 Miga PF10265.9 CDI87022.1 - 0.26 10.2 20.9 0.33 9.9 20.9 1.2 1 0 0 1 1 1 0 Mitoguardin CDC27 PF09507.10 CDI87022.1 - 0.37 10.1 41.5 0.47 9.8 41.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RskA PF10099.9 CDI87022.1 - 0.46 10.8 8.3 0.45 10.8 6.8 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA K_channel_TID PF07941.11 CDI87022.1 - 0.71 10.4 10.0 0.064 13.7 4.8 1.9 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain TFIIA PF03153.13 CDI87022.1 - 0.73 9.8 38.4 0.92 9.4 38.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Merozoite_SPAM PF07133.11 CDI87022.1 - 1.7 8.6 54.8 0.28 11.2 50.3 1.9 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) DER1 PF04511.15 CDI87024.1 - 5.4e-11 42.8 0.1 1.3e-10 41.5 0.1 1.6 2 0 0 2 2 2 1 Der1-like family DUF755 PF05501.11 CDI87024.1 - 0.005 17.1 33.7 0.005 17.1 33.7 3.4 3 1 0 3 3 3 1 Domain of unknown function (DUF755) SUIM_assoc PF16619.5 CDI87024.1 - 0.015 15.3 3.0 0.015 15.3 3.0 6.6 3 2 1 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI87024.1 - 0.015 15.6 13.7 0.015 15.6 13.7 5.7 2 2 2 5 5 5 0 Anti-sigma-K factor rskA O-antigen_lig PF13425.6 CDI87024.1 - 4.8 5.9 7.2 1.6 7.4 0.1 2.3 2 0 0 2 2 2 0 O-antigen ligase like membrane protein Mem_trans PF03547.18 CDI87024.1 - 9.8 4.4 9.4 1.6 7.0 4.2 2.3 2 0 0 2 2 2 0 Membrane transport protein Activator_LAG-3 PF11498.8 CDI87025.1 - 0.00021 20.4 6.6 0.00021 20.4 6.6 7.7 5 3 1 6 6 6 2 Transcriptional activator LAG-3 Pkinase PF00069.25 CDI87026.1 - 1.1e-37 129.9 0.0 1.6e-33 116.2 0.0 2.1 1 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI87026.1 - 3e-22 79.2 0.0 4e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI87026.1 - 2.8e-07 30.1 0.0 5.8e-07 29.1 0.0 1.4 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CDI87026.1 - 1.6e-06 27.2 0.0 2e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDI87026.1 - 8.1e-05 22.7 0.1 0.00028 20.9 0.1 1.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDI87026.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CDI87026.1 - 0.2 11.2 0.0 0.37 10.4 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Caldesmon PF02029.15 CDI87027.1 - 0.0012 17.7 77.6 0.0012 17.7 77.6 3.6 2 1 0 3 3 3 1 Caldesmon RskA PF10099.9 CDI87028.1 - 0.0016 18.8 10.7 0.0016 18.8 10.7 18.3 2 1 11 13 13 13 1 Anti-sigma-K factor rskA RNA_pol_Rpb1_2 PF00623.20 CDI87029.1 - 1.9e-13 51.0 7.0 2.1e-13 50.8 0.4 2.4 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RskA PF10099.9 CDI87029.1 - 0.00063 20.1 17.4 0.00067 20.0 9.4 2.1 2 0 0 2 2 2 1 Anti-sigma-K factor rskA RAP1 PF07218.11 CDI87029.1 - 0.006 14.9 6.5 0.0055 15.1 6.5 1.2 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) ANAPC_CDC26 PF10471.9 CDI87029.1 - 0.03 15.1 4.1 0.03 15.1 4.1 3.5 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 LptF_LptG PF03739.14 CDI87029.1 - 0.097 11.5 3.2 0.72 8.6 0.4 2.1 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG DUF3169 PF11368.8 CDI87029.1 - 0.18 11.3 0.1 0.29 10.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Trp_oprn_chp PF09534.10 CDI87029.1 - 0.24 11.2 7.8 0.086 12.6 3.3 1.9 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) TCP PF03634.13 CDI87029.1 - 0.29 11.7 21.9 0.39 11.3 14.7 2.2 2 0 0 2 2 2 0 TCP family transcription factor DUF572 PF04502.13 CDI87029.1 - 0.71 9.4 21.0 0.86 9.2 21.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) TMEM208_SND2 PF05620.11 CDI87029.1 - 0.79 9.5 11.6 0.032 14.0 2.9 2.1 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Peptidase_S49_N PF08496.10 CDI87029.1 - 1.1 9.3 16.8 0.53 10.3 0.8 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal CD20 PF04103.15 CDI87029.1 - 3.7 7.6 7.5 0.28 11.2 0.4 2.2 1 1 1 2 2 2 0 CD20-like family U1snRNP70_N PF12220.8 CDI87029.1 - 4.5 8.0 14.5 2.7 8.7 5.5 2.4 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF3767 PF12597.8 CDI87029.1 - 9.9 6.1 11.8 0.047 13.5 1.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3767) DUF3506 PF12014.8 CDI87030.1 - 0.014 15.4 2.0 0.017 15.1 2.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3506) Peroxin-13_N PF04088.13 CDI87030.1 - 0.038 14.3 3.2 0.046 14.0 3.2 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Pex14_N PF04695.13 CDI87030.1 - 0.047 14.4 10.7 0.045 14.4 10.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region STAC2_u1 PF16664.5 CDI87030.1 - 0.075 13.5 3.2 0.086 13.3 3.2 1.0 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Pal1 PF08316.11 CDI87030.1 - 0.9 10.3 2.7 1 10.1 2.7 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein Orf78 PF06024.12 CDI87030.1 - 1.2 9.5 6.5 2.3 8.6 6.5 1.6 1 1 0 1 1 1 0 Orf78 (ac78) Suf PF05843.14 CDI87030.1 - 1.3 8.9 12.1 1.4 8.8 12.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) WBS_methylT PF12589.8 CDI87030.1 - 5.5 7.8 11.2 6.9 7.5 11.2 1.1 1 0 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome SlyX PF04102.12 CDI87031.1 - 0.56 10.9 0.1 0.56 10.9 0.1 2.8 3 0 0 3 3 3 0 SlyX HMA PF00403.26 CDI87032.1 - 1.1e-18 67.4 0.2 6.5e-08 32.9 0.0 2.6 3 0 0 3 3 3 2 Heavy-metal-associated domain DUF3446 PF11928.8 CDI87032.1 - 0.53 10.6 17.3 0.62 10.4 0.6 3.4 3 0 0 3 3 3 0 Early growth response N-terminal domain KCNQ2_u3 PF16642.5 CDI87032.1 - 2.3 9.2 6.3 1.3 10.0 2.7 2.2 2 0 0 2 2 2 0 Unstructured region on Potassium channel subunit alpha KvLQT2 DUF3824 PF12868.7 CDI87033.1 - 0.038 14.6 30.0 0.077 13.7 30.0 1.5 1 1 0 1 1 1 0 Domain of unknwon function (DUF3824) Ribosomal_60s PF00428.19 CDI87033.1 - 1.8 9.2 6.1 2.8 8.6 3.7 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein MAP70 PF07058.11 CDI87033.1 - 2.7 6.7 21.2 3.7 6.2 21.2 1.2 1 0 0 1 1 1 0 Microtubule-associated protein 70 RIFIN PF02009.16 CDI87033.1 - 4.3 7.1 19.5 5.5 6.8 19.5 1.1 1 0 0 1 1 1 0 Rifin CAC1F_C PF16885.5 CDI87033.1 - 8.8 5.9 28.9 12 5.5 28.9 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term SDA1 PF05285.12 CDI87034.1 - 0.018 14.5 15.9 0.022 14.2 15.9 1.1 1 0 0 1 1 1 0 SDA1 MAT1 PF06391.13 CDI87034.1 - 0.06 13.2 26.5 0.068 13.0 26.5 1.0 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DAG_kinase_N PF14513.6 CDI87034.1 - 0.064 13.5 14.1 0.081 13.1 14.1 1.1 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus DUF5427 PF10310.9 CDI87034.1 - 0.093 11.7 20.3 0.11 11.5 20.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF1645 PF07816.11 CDI87034.1 - 0.16 12.5 12.5 0.21 12.1 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) SMYLE_N PF18615.1 CDI87034.1 - 0.17 11.4 15.1 0.21 11.1 15.1 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain FAM60A PF15396.6 CDI87034.1 - 0.22 11.5 13.1 0.34 10.9 13.1 1.3 1 0 0 1 1 1 0 Protein Family FAM60A V_ATPase_I PF01496.19 CDI87034.1 - 0.25 9.2 17.2 0.29 9.0 17.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CAF1 PF04857.20 CDI87034.1 - 0.35 10.0 11.7 0.41 9.8 11.7 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease RR_TM4-6 PF06459.12 CDI87034.1 - 0.41 10.4 19.4 0.51 10.1 19.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 EIIBC-GUT_N PF03612.14 CDI87034.1 - 0.43 10.3 17.9 0.089 12.5 6.7 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 CDI87034.1 - 0.53 9.0 24.3 0.63 8.7 24.3 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI87034.1 - 0.72 8.8 20.5 0.85 8.6 20.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF913 PF06025.12 CDI87034.1 - 1.1 8.2 12.5 1.5 7.7 12.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Neur_chan_memb PF02932.16 CDI87034.1 - 1.2 9.1 17.0 1.5 8.8 17.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CCSAP PF15748.5 CDI87034.1 - 1.2 9.2 22.4 1.5 8.9 22.4 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Zip PF02535.22 CDI87034.1 - 1.4 8.1 14.9 1.7 7.8 14.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2098 PF09871.9 CDI87034.1 - 1.4 9.3 8.7 0.53 10.6 0.9 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) PNISR PF15996.5 CDI87034.1 - 1.8 8.8 28.6 2.3 8.5 28.6 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR TERB2 PF15101.6 CDI87034.1 - 1.8 8.5 32.1 0.95 9.5 17.7 2.0 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF4045 PF13254.6 CDI87034.1 - 1.9 8.1 21.2 2 8.0 21.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF572 PF04502.13 CDI87034.1 - 2 7.9 18.1 2.6 7.6 18.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) CDC45 PF02724.14 CDI87034.1 - 2.4 6.4 18.0 3 6.0 18.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Lin-8 PF03353.15 CDI87034.1 - 2.5 7.6 27.2 3.1 7.3 27.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Neuregulin PF02158.15 CDI87034.1 - 2.5 7.4 21.9 3.1 7.1 21.9 1.0 1 0 0 1 1 1 0 Neuregulin intracellular region DUF2956 PF11169.8 CDI87034.1 - 2.7 8.2 29.0 1.9 8.8 13.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2956) Dehalogenase PF13486.6 CDI87034.1 - 3.1 7.1 15.2 0.017 14.6 4.8 1.9 1 1 1 2 2 2 0 Reductive dehalogenase subunit tRNA_synt_1c_R2 PF04557.15 CDI87034.1 - 3.2 8.7 17.1 2.8 8.9 8.0 2.1 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 PBP1_TM PF14812.6 CDI87034.1 - 3.9 7.9 8.2 4.6 7.7 2.0 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal IER PF05760.12 CDI87034.1 - 4 7.7 22.1 4.8 7.4 22.1 1.0 1 0 0 1 1 1 0 Immediate early response protein (IER) DUF1840 PF08895.11 CDI87034.1 - 4.7 7.6 17.5 4.3 7.7 6.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Peroxin-3 PF04882.12 CDI87034.1 - 5.3 5.9 26.9 6.2 5.7 26.9 1.0 1 0 0 1 1 1 0 Peroxin-3 Spt20 PF12090.8 CDI87034.1 - 5.7 6.5 60.7 0.57 9.7 31.4 2.0 2 0 0 2 2 2 0 Spt20 family SNF5 PF04855.12 CDI87034.1 - 6.2 6.5 17.3 7.5 6.3 17.3 1.0 1 0 0 1 1 1 0 SNF5 / SMARCB1 / INI1 XRN_M PF17846.1 CDI87034.1 - 6.9 5.5 15.0 8.3 5.2 15.0 1.1 1 0 0 1 1 1 0 Xrn1 helical domain LPP20 PF02169.16 CDI87034.1 - 7.1 7.0 27.8 4.2 7.8 11.8 2.1 2 0 0 2 2 2 0 LPP20 lipoprotein AF-4 PF05110.13 CDI87034.1 - 7.5 4.5 28.9 9.7 4.1 28.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein G0-G1_switch_2 PF15103.6 CDI87034.1 - 7.9 7.0 17.5 2.5 8.6 7.2 2.1 2 0 0 2 2 2 0 G0/G1 switch protein 2 ALMT PF11744.8 CDI87034.1 - 8.2 5.1 17.4 10 4.8 17.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter MDFI PF15316.6 CDI87034.1 - 8.3 6.5 16.1 11 6.1 16.1 1.1 1 0 0 1 1 1 0 MyoD family inhibitor DUF3464 PF11947.8 CDI87034.1 - 9.9 5.9 21.0 7.4 6.3 10.3 2.1 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Peptidase_M28 PF04389.17 CDI87035.1 - 0.0065 16.2 0.0 0.0094 15.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Golgin_A5 PF09787.9 CDI87037.1 - 0.13 11.7 23.9 0.21 11.0 23.9 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 TFIIA PF03153.13 CDI87037.1 - 0.48 10.4 31.0 0.6 10.0 31.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.15 CDI87037.1 - 0.91 9.0 31.8 1.2 8.7 31.8 1.2 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF812 PF05667.11 CDI87037.1 - 2.1 7.1 28.5 2.4 6.9 28.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) FapA PF03961.13 CDI87037.1 - 2.4 6.6 12.4 3.4 6.2 12.4 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A COG5 PF10392.9 CDI87037.1 - 2.9 8.1 19.9 3.2 7.9 17.9 1.8 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Spc7 PF08317.11 CDI87037.1 - 3.3 6.5 28.7 4.1 6.2 28.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein RskA PF10099.9 CDI87037.1 - 6.2 7.1 28.7 29 4.9 28.7 2.2 1 1 0 1 1 1 0 Anti-sigma-K factor rskA V_ATPase_I PF01496.19 CDI87038.1 - 0.025 12.5 16.8 0.024 12.6 16.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Afi1 PF07792.12 CDI87038.1 - 0.067 13.7 13.2 0.077 13.5 13.2 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF913 PF06025.12 CDI87038.1 - 0.11 11.4 12.5 0.12 11.3 12.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CPSF100_C PF13299.6 CDI87038.1 - 0.16 12.2 17.6 0.18 12.0 17.6 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal OATP PF03137.20 CDI87038.1 - 0.18 10.1 7.9 0.21 9.9 7.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family RR_TM4-6 PF06459.12 CDI87038.1 - 0.18 11.6 18.7 0.19 11.5 18.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4666 PF15697.5 CDI87038.1 - 0.19 12.5 12.8 0.21 12.3 12.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4666) Connexin PF00029.19 CDI87038.1 - 0.23 11.2 12.9 0.23 11.2 12.9 1.1 1 0 0 1 1 1 0 Connexin DUF4637 PF15470.6 CDI87038.1 - 0.28 10.9 10.1 0.31 10.8 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) NARP1 PF12569.8 CDI87038.1 - 0.36 9.7 14.9 0.36 9.7 14.9 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Apc15p PF05841.11 CDI87038.1 - 0.38 11.5 23.9 1.1 10.1 23.9 1.7 1 1 0 1 1 1 0 Apc15p protein DUF2370 PF10176.9 CDI87038.1 - 0.47 10.1 7.8 0.47 10.1 7.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF1764 PF08576.10 CDI87038.1 - 0.53 11.2 14.7 0.72 10.8 14.7 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) FAM60A PF15396.6 CDI87038.1 - 0.63 10.0 13.2 0.71 9.8 13.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SpoIIP PF07454.11 CDI87038.1 - 0.66 9.4 21.0 0.65 9.4 21.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) GNAT_acetyltr_2 PF13718.6 CDI87038.1 - 0.98 8.8 9.8 1.2 8.5 9.8 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 CSG2 PF16965.5 CDI87038.1 - 1.1 8.2 9.7 0.99 8.3 9.7 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator MCM_bind PF09739.9 CDI87038.1 - 1.1 7.6 16.6 1.2 7.5 16.6 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CDC45 PF02724.14 CDI87038.1 - 1.3 7.3 16.6 1.4 7.1 16.6 1.0 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.17 CDI87038.1 - 1.3 9.1 15.9 1.6 8.9 15.9 1.2 1 0 0 1 1 1 0 DDHD domain DUF2151 PF10221.9 CDI87038.1 - 1.7 7.2 11.9 1.9 7.0 11.9 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator MMU163 PF17119.5 CDI87038.1 - 1.8 7.6 9.2 2.2 7.4 9.2 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis CobT PF06213.12 CDI87038.1 - 1.9 7.8 31.0 2.1 7.7 31.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TRAP_alpha PF03896.16 CDI87038.1 - 2 7.6 11.0 2 7.5 11.0 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF3984 PF13136.6 CDI87038.1 - 2.1 7.6 16.6 2.5 7.4 16.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) Isy1 PF06246.12 CDI87038.1 - 2.2 7.8 19.5 2.3 7.7 19.5 1.0 1 0 0 1 1 1 0 Isy1-like splicing family DUF4045 PF13254.6 CDI87038.1 - 2.2 7.8 19.2 2.4 7.7 19.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) RNA_pol_Rpc4 PF05132.14 CDI87038.1 - 2.4 8.6 20.4 3 8.3 20.4 1.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF5308 PF17233.2 CDI87038.1 - 2.5 8.3 16.2 3 8.1 16.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF853 PF05872.12 CDI87038.1 - 3.3 6.2 15.1 4 5.9 15.1 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF2126 PF09899.9 CDI87038.1 - 3.5 5.6 14.6 3.5 5.6 14.6 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Membralin PF09746.9 CDI87038.1 - 3.5 6.6 12.8 3.9 6.4 12.8 1.0 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 CDI87038.1 - 3.5 6.3 25.7 4 6.1 25.7 1.0 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI87038.1 - 3.6 6.5 20.1 3.7 6.5 20.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Gti1_Pac2 PF09729.9 CDI87038.1 - 3.6 7.6 17.3 4.1 7.4 17.3 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family CCDC53 PF10152.9 CDI87038.1 - 3.7 8.0 22.2 4.2 7.8 22.2 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex GREB1 PF15782.5 CDI87038.1 - 3.7 4.5 19.6 4.1 4.4 19.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 CDI87038.1 - 3.8 7.5 17.3 4.4 7.3 17.3 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CLN3 PF02487.17 CDI87038.1 - 3.9 6.4 15.8 3.9 6.4 15.8 1.0 1 0 0 1 1 1 0 CLN3 protein FemAB PF02388.16 CDI87038.1 - 4.1 6.2 16.4 4.5 6.0 16.4 1.0 1 0 0 1 1 1 0 FemAB family Pal1 PF08316.11 CDI87038.1 - 4.6 8.0 11.1 5.2 7.8 11.1 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein ALMT PF11744.8 CDI87038.1 - 4.7 5.9 15.5 4.8 5.9 15.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec62 PF03839.16 CDI87038.1 - 4.7 6.6 16.3 5.4 6.5 16.3 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 ATAD4 PF15321.6 CDI87038.1 - 4.8 8.6 13.9 7 8.1 13.9 1.3 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 MMM1 PF10296.9 CDI87038.1 - 4.9 6.1 11.2 5.6 5.9 11.2 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Ctr PF04145.15 CDI87038.1 - 5 7.7 12.5 6 7.5 12.5 1.1 1 0 0 1 1 1 0 Ctr copper transporter family eIF-3_zeta PF05091.12 CDI87038.1 - 5.2 5.9 25.2 5.4 5.9 25.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Mem_trans PF03547.18 CDI87038.1 - 5.3 5.3 7.4 5.7 5.2 7.4 1.0 1 0 0 1 1 1 0 Membrane transport protein Hydin_ADK PF17213.3 CDI87038.1 - 5.4 7.2 17.6 6.8 6.9 17.6 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain PA26 PF04636.13 CDI87038.1 - 5.4 5.8 13.8 5.7 5.7 13.8 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF5427 PF10310.9 CDI87038.1 - 5.6 5.8 24.1 6.3 5.6 24.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Rtf2 PF04641.12 CDI87038.1 - 6 6.1 18.2 7.3 5.9 18.2 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger UPF0560 PF10577.9 CDI87038.1 - 6.2 5.2 31.8 6.5 5.1 31.8 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 YABBY PF04690.13 CDI87038.1 - 6.2 7.4 15.7 6.7 7.3 15.7 1.1 1 0 0 1 1 1 0 YABBY protein Peptidase_S64 PF08192.11 CDI87038.1 - 6.5 5.1 18.1 7.2 5.0 18.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Pex14_N PF04695.13 CDI87038.1 - 6.5 7.4 31.0 7.8 7.1 31.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Tim54 PF11711.8 CDI87038.1 - 6.6 5.4 21.1 7.5 5.2 21.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF1387 PF07139.11 CDI87038.1 - 6.8 6.3 20.1 7.6 6.2 20.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) EPL1 PF10513.9 CDI87038.1 - 7 7.0 22.7 8.6 6.7 22.7 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF4746 PF15928.5 CDI87038.1 - 7 6.0 17.9 8 5.8 17.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PPL5 PF18168.1 CDI87038.1 - 7.1 5.8 15.0 7.7 5.7 15.0 1.0 1 0 0 1 1 1 0 Prim-pol family 5 DUF3295 PF11702.8 CDI87038.1 - 7.5 5.8 21.9 9.1 5.5 21.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DUF2052 PF09747.9 CDI87038.1 - 7.6 6.6 22.6 8.5 6.5 22.6 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4638 PF15472.6 CDI87038.1 - 8 6.1 17.6 8.9 6.0 17.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF3306 PF11748.8 CDI87038.1 - 8.1 7.3 20.1 10 7.0 20.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) DDRGK PF09756.9 CDI87038.1 - 8.2 6.0 28.2 9.8 5.7 28.2 1.0 1 0 0 1 1 1 0 DDRGK domain TFB6 PF17110.5 CDI87038.1 - 8.6 6.1 13.9 12 5.6 13.9 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Band_3_cyto PF07565.13 CDI87038.1 - 9.4 5.9 18.5 11 5.8 18.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain F-protein PF00469.20 CDI87038.1 - 9.7 5.7 15.9 11 5.5 15.9 1.0 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef DUF2464 PF10240.9 CDI87038.1 - 9.9 5.6 13.9 11 5.4 13.9 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 PIP5K PF01504.18 CDI87038.1 - 10 5.3 17.2 11 5.1 17.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2722 PF10846.8 CDI87039.1 - 0.0061 15.6 15.4 0.0071 15.3 15.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI87039.1 - 0.012 15.3 26.1 0.014 15.0 26.1 1.1 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI87039.1 - 0.06 13.3 22.5 0.083 12.9 22.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4820 PF16091.5 CDI87039.1 - 0.13 11.6 7.7 0.14 11.5 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) MPM1 PF17234.2 CDI87039.1 - 0.18 12.0 6.6 0.2 11.9 6.6 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 EIF4E-T PF10477.9 CDI87039.1 - 0.42 9.4 9.6 0.44 9.3 9.6 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E CDK2AP PF09806.9 CDI87039.1 - 0.57 10.2 20.8 0.73 9.9 20.8 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein NST1 PF13945.6 CDI87039.1 - 0.62 10.1 13.8 0.79 9.8 13.8 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator ASFV_J13L PF05568.11 CDI87039.1 - 0.95 9.2 15.9 1.2 8.9 15.9 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein AUX_IAA PF02309.16 CDI87039.1 - 1 9.2 8.5 1.3 8.8 8.5 1.0 1 0 0 1 1 1 0 AUX/IAA family PCM1_C PF15717.5 CDI87039.1 - 1.5 7.4 12.4 1.7 7.2 12.4 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Mcm10 PF09332.11 CDI87039.1 - 1.6 8.0 12.3 1.9 7.8 12.3 1.1 1 0 0 1 1 1 0 Mcm10 replication factor NUDE_C PF04880.13 CDI87039.1 - 2.1 8.8 13.5 2.5 8.6 13.5 1.1 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region DUF572 PF04502.13 CDI87039.1 - 4.2 6.9 10.6 5 6.6 10.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) MMR1 PF08505.10 CDI87039.1 - 4.2 7.6 13.2 5.1 7.3 13.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Hid1 PF12722.7 CDI87039.1 - 4.4 5.3 11.2 5 5.1 11.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macoilin PF09726.9 CDI87039.1 - 5.1 5.5 10.1 6.1 5.3 10.1 1.0 1 0 0 1 1 1 0 Macoilin family RIFIN PF02009.16 CDI87039.1 - 5.7 6.7 15.0 6.7 6.5 15.0 1.1 1 0 0 1 1 1 0 Rifin Paramyxo_ncap PF00973.19 CDI87039.1 - 7 5.4 7.8 7.4 5.4 7.8 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein SLC12 PF03522.15 CDI87039.1 - 7.3 5.5 9.2 8.4 5.3 9.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 IER PF05760.12 CDI87039.1 - 9.6 6.4 19.9 12 6.1 19.9 1.0 1 0 0 1 1 1 0 Immediate early response protein (IER) TMEM65 PF10507.9 CDI87040.1 - 0.024 14.6 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 65 RskA PF10099.9 CDI87041.1 - 0.0024 18.2 20.9 0.0024 18.2 20.9 8.4 2 2 3 6 6 6 1 Anti-sigma-K factor rskA Connexin PF00029.19 CDI87041.1 - 0.016 15.0 1.6 0.016 15.0 1.6 6.2 4 2 0 4 4 4 0 Connexin PAPA-1 PF04795.12 CDI87042.1 - 3.7 8.4 39.9 8.4 7.3 0.7 3.2 3 0 0 3 3 3 0 PAPA-1-like conserved region GTP_EFTU PF00009.27 CDI87043.1 - 1.4e-16 60.6 0.0 1.8e-07 30.9 0.0 3.0 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain EFG_II PF14492.6 CDI87043.1 - 1.5e-10 41.0 0.0 3.2e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 CDI87043.1 - 7.7e-06 25.8 1.9 1.1e-05 25.3 0.0 2.2 3 0 0 3 3 3 1 Class II release factor RF3, C-terminal domain GTP_EFTU_D2 PF03144.25 CDI87043.1 - 0.0031 17.9 0.0 0.0098 16.3 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 TrbC_Ftype PF09673.10 CDI87043.1 - 0.0078 16.3 0.2 0.0078 16.3 0.2 2.6 2 0 0 2 2 2 1 Type-F conjugative transfer system pilin assembly protein LptF_LptG PF03739.14 CDI87043.1 - 0.55 9.0 6.2 0.31 9.8 0.7 2.3 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG Calici_coat_C PF08435.11 CDI87043.1 - 3.3 7.2 8.0 4.1 6.9 2.5 2.6 2 0 0 2 2 2 0 Calicivirus coat protein C-terminal DUF4834 PF16118.5 CDI87044.1 - 5 8.2 0.0 5 8.2 0.0 9.0 4 2 1 5 5 5 0 Domain of unknown function (DUF4834) KH_1 PF00013.29 CDI87046.1 - 3.1e-41 139.0 0.0 3.6e-11 42.7 0.2 5.8 6 0 0 6 6 6 4 KH domain KH_2 PF07650.17 CDI87046.1 - 0.021 14.6 0.0 4.8 7.1 0.0 3.2 3 0 0 3 3 3 0 KH domain Pkinase PF00069.25 CDI87047.1 - 1e-20 74.2 0.0 6e-20 71.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CDI87047.1 - 3.3e-19 69.3 0.0 4.8e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 CDI87047.1 - 0.00014 21.2 0.0 0.00034 20.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDI87047.1 - 0.0019 17.6 0.0 0.0033 16.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MFS_1 PF07690.16 CDI87048.1 - 4.4e-12 45.6 40.6 1.2e-06 27.8 12.9 3.1 1 1 2 3 3 3 3 Major Facilitator Superfamily Beta-lactamase PF00144.24 CDI87049.1 - 1.1e-42 146.5 0.3 1.5e-37 129.6 0.0 3.2 2 1 0 2 2 2 2 Beta-lactamase ABC1 PF03109.16 CDI87049.1 - 8.7e-24 84.0 0.0 1.8e-23 83.0 0.0 1.5 1 0 0 1 1 1 1 ABC1 family WaaY PF06176.11 CDI87049.1 - 0.003 17.2 0.0 0.005 16.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.22 CDI87049.1 - 0.0056 16.3 0.1 0.018 14.7 0.0 1.8 2 0 0 2 2 2 1 RIO1 family RabGAP-TBC PF00566.18 CDI87050.1 - 3.3e-29 102.1 5.5 1.4e-28 100.0 0.2 2.9 3 0 0 3 3 3 2 Rab-GTPase-TBC domain ALMS_motif PF15309.6 CDI87050.1 - 0.024 15.1 1.3 0.024 15.1 1.3 2.0 2 0 0 2 2 2 0 ALMS motif Kinase-like PF14531.6 CDI87051.1 - 6e-15 55.3 0.0 9.6e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like SOBP PF15279.6 CDI87051.1 - 0.6 10.7 13.4 1.1 9.8 13.4 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Mito_carr PF00153.27 CDI87052.1 - 7.2e-27 93.2 21.6 3.5e-10 39.7 0.0 4.8 4 1 0 4 4 4 3 Mitochondrial carrier protein Adap_comp_sub PF00928.21 CDI87053.1 - 7e-86 287.9 0.0 8.4e-86 287.6 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CDI87053.1 - 3.9e-05 23.6 0.1 7.2e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain LapA_dom PF06305.11 CDI87054.1 - 0.11 12.3 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain HSM3_C PF18794.1 CDI87055.1 - 0.0055 16.3 0.3 1.7 8.2 0.1 2.2 1 1 0 2 2 2 2 DNA mismatch repair protein HSM3, C terminal domain Atrophin-1 PF03154.15 CDI87056.1 - 0.016 13.5 2.5 0.021 13.1 2.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.6 CDI87056.1 - 0.017 15.1 1.2 0.03 14.3 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) NPR3 PF03666.13 CDI87057.1 - 0.0028 16.5 2.2 0.003 16.4 2.2 1.0 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 FAM176 PF14851.6 CDI87057.1 - 0.0056 16.4 2.3 0.0056 16.4 2.3 1.0 1 0 0 1 1 1 1 FAM176 family PFL-like PF02901.15 CDI87057.1 - 0.0082 14.8 1.5 0.0085 14.8 1.5 1.1 1 0 0 1 1 1 1 Pyruvate formate lyase-like DUF4746 PF15928.5 CDI87057.1 - 0.014 14.8 2.2 0.016 14.7 2.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MotA_ExbB PF01618.16 CDI87057.1 - 0.037 13.8 0.3 0.043 13.6 0.3 1.1 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family Orf78 PF06024.12 CDI87057.1 - 0.039 14.2 1.9 0.046 14.0 1.9 1.1 1 0 0 1 1 1 0 Orf78 (ac78) DUF913 PF06025.12 CDI87057.1 - 0.044 12.8 1.1 0.045 12.7 1.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) EIIBC-GUT_N PF03612.14 CDI87057.1 - 0.052 13.3 5.1 0.055 13.2 5.1 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus RNase_H2_suC PF08615.11 CDI87057.1 - 0.059 13.5 2.4 0.064 13.4 2.4 1.1 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DUF4770 PF15994.5 CDI87057.1 - 0.059 13.6 5.9 0.059 13.6 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF3464 PF11947.8 CDI87057.1 - 0.062 13.0 3.8 0.06 13.1 3.8 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Peroxin-13_N PF04088.13 CDI87057.1 - 0.07 13.4 0.8 0.079 13.2 0.8 1.0 1 0 0 1 1 1 0 Peroxin 13, N-terminal region MMR1 PF08505.10 CDI87057.1 - 0.14 12.5 8.5 0.14 12.4 8.5 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Suf PF05843.14 CDI87057.1 - 0.14 12.1 7.9 0.14 12.1 7.9 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CPSF100_C PF13299.6 CDI87057.1 - 0.15 12.2 4.1 0.17 12.1 4.1 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SpoIIP PF07454.11 CDI87057.1 - 0.16 11.4 6.8 0.16 11.4 6.8 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TERB2 PF15101.6 CDI87057.1 - 0.16 12.0 8.6 0.17 12.0 8.6 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 PEX11 PF05648.14 CDI87057.1 - 0.17 11.4 1.3 0.17 11.3 1.3 1.0 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Tim54 PF11711.8 CDI87057.1 - 0.19 10.5 5.2 0.21 10.3 5.2 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF775 PF05603.12 CDI87057.1 - 0.2 11.2 5.5 0.2 11.2 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) MscS_TM PF12794.7 CDI87057.1 - 0.32 9.8 7.8 0.36 9.6 7.8 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 TFIIA PF03153.13 CDI87057.1 - 0.32 10.9 19.2 0.32 10.9 19.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 CDI87057.1 - 0.33 8.8 6.4 0.34 8.8 6.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 CDI87057.1 - 0.38 10.5 4.7 0.4 10.4 4.7 1.0 1 0 0 1 1 1 0 Connexin EOS1 PF12326.8 CDI87057.1 - 0.39 10.6 0.9 0.42 10.5 0.9 1.1 1 0 0 1 1 1 0 N-glycosylation protein RNA_pol_Rbc25 PF08292.12 CDI87057.1 - 0.44 10.8 7.0 0.54 10.5 7.0 1.1 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 DUF2722 PF10846.8 CDI87057.1 - 0.47 9.3 18.1 0.45 9.4 18.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) OATP PF03137.20 CDI87057.1 - 0.49 8.6 2.9 0.51 8.6 2.9 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Pex14_N PF04695.13 CDI87057.1 - 0.51 11.0 10.2 0.54 10.9 10.2 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region XK-related PF09815.9 CDI87057.1 - 0.71 8.9 1.3 0.74 8.8 1.3 1.0 1 0 0 1 1 1 0 XK-related protein Ureide_permease PF07168.11 CDI87057.1 - 0.72 8.5 1.8 0.72 8.5 1.8 1.0 1 0 0 1 1 1 0 Ureide permease Zip PF02535.22 CDI87057.1 - 0.88 8.7 4.5 0.92 8.7 4.5 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DDHD PF02862.17 CDI87057.1 - 1 9.5 6.7 1.1 9.3 6.7 1.0 1 0 0 1 1 1 0 DDHD domain RED_N PF07808.13 CDI87057.1 - 1.1 8.7 10.2 1.2 8.6 10.2 1.0 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF4820 PF16091.5 CDI87057.1 - 1.5 8.1 7.8 1.7 7.9 7.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Glt_symporter PF03616.14 CDI87057.1 - 1.6 7.4 2.6 1.8 7.2 2.6 1.0 1 0 0 1 1 1 0 Sodium/glutamate symporter Sec62 PF03839.16 CDI87057.1 - 2 7.9 5.7 2.3 7.7 5.7 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 EMC3_TMCO1 PF01956.16 CDI87057.1 - 2.2 8.0 5.2 2.3 7.9 5.2 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like CLN3 PF02487.17 CDI87057.1 - 2.2 7.2 4.9 2.4 7.1 4.9 1.0 1 0 0 1 1 1 0 CLN3 protein Neur_chan_memb PF02932.16 CDI87057.1 - 2.6 8.0 5.1 2.6 8.0 5.1 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FHIPEP PF00771.20 CDI87057.1 - 2.8 6.3 6.1 3 6.2 6.1 1.0 1 0 0 1 1 1 0 FHIPEP family DUF4199 PF13858.6 CDI87057.1 - 3 8.2 3.5 3 8.2 3.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) ALMT PF11744.8 CDI87057.1 - 3.8 6.2 5.1 4.1 6.1 5.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CbtA PF09490.10 CDI87057.1 - 4.7 6.9 4.0 5.1 6.8 4.0 1.1 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) Presenilin PF01080.17 CDI87057.1 - 4.7 5.9 11.1 5.5 5.6 11.1 1.0 1 0 0 1 1 1 0 Presenilin Folate_carrier PF01770.18 CDI87057.1 - 5.4 5.6 5.9 6 5.5 5.9 1.0 1 0 0 1 1 1 0 Reduced folate carrier UPF0560 PF10577.9 CDI87057.1 - 6.4 5.1 12.5 6.8 5.1 12.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TMEM51 PF15345.6 CDI87057.1 - 8.1 6.2 13.2 9.3 6.0 13.2 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 AIF_C PF14721.6 CDI87057.1 - 8.1 6.8 8.1 9.8 6.6 8.1 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Roughex PF06020.11 CDI87057.1 - 8.8 5.3 13.6 12 4.9 13.6 1.3 1 0 0 1 1 1 0 Drosophila roughex protein ACBP PF00887.19 CDI87058.1 - 2.5e-05 24.4 11.1 0.00094 19.3 0.6 3.2 1 1 1 2 2 2 2 Acyl CoA binding protein TFIIA PF03153.13 CDI87058.1 - 0.00042 20.4 25.6 0.00042 20.4 25.6 2.8 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Sporozoite_P67 PF05642.11 CDI87058.1 - 0.023 12.8 0.1 0.023 12.8 0.1 2.1 1 1 1 2 2 2 0 Sporozoite P67 surface antigen DDHD PF02862.17 CDI87058.1 - 0.29 11.3 26.4 1.5 8.9 7.0 2.4 2 0 0 2 2 2 0 DDHD domain PAT1 PF09770.9 CDI87058.1 - 0.54 8.5 66.7 0.43 8.8 31.2 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 CDI87058.1 - 0.93 8.2 43.1 1.2 7.8 15.5 2.2 2 0 0 2 2 2 0 Presenilin DUF3295 PF11702.8 CDI87058.1 - 2.3 7.5 37.4 0.64 9.3 13.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) PEX-1N PF09262.11 CDI87059.1 - 1.8e-13 50.7 2.1 5.1e-13 49.2 2.1 1.8 1 1 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal DUF2722 PF10846.8 CDI87059.1 - 5.4e-13 48.7 29.5 1.1e-05 24.6 6.4 3.3 3 0 0 3 3 3 3 Protein of unknown function (DUF2722) Med15 PF09606.10 CDI87059.1 - 8.1e-05 21.5 53.6 0.028 13.1 12.0 3.3 3 0 0 3 3 3 3 ARC105 or Med15 subunit of Mediator complex non-fungal ANAPC_CDC26 PF10471.9 CDI87059.1 - 0.0042 17.9 68.1 0.0045 17.8 10.5 4.5 4 0 0 4 4 3 2 Anaphase-promoting complex APC subunit CDC26 SUIM_assoc PF16619.5 CDI87059.1 - 0.0055 16.7 3.4 0.0055 16.7 3.4 6.6 4 2 1 5 5 2 1 Unstructured region C-term to UIM in Ataxin3 PIP5K PF01504.18 CDI87059.1 - 0.0065 15.7 4.5 0.025 13.8 0.5 2.4 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Spt20 PF12090.8 CDI87059.1 - 0.05 13.2 78.5 0.02 14.5 8.4 3.3 3 0 0 3 3 3 0 Spt20 family EPL1 PF10513.9 CDI87059.1 - 0.054 13.9 19.9 0.59 10.5 1.7 3.5 3 0 0 3 3 3 0 Enhancer of polycomb-like Folliculin PF11704.8 CDI87059.1 - 0.087 12.7 9.1 4.5 7.1 0.3 3.6 3 0 0 3 3 3 0 Vesicle coat protein involved in Golgi to plasma membrane transport MecA PF05389.12 CDI87059.1 - 0.091 12.4 11.8 1.1 8.9 0.9 3.3 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) RNase_H2_suC PF08615.11 CDI87059.1 - 0.12 12.5 4.0 17 5.6 0.0 3.4 3 0 0 3 3 3 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Ctr PF04145.15 CDI87059.1 - 0.29 11.8 6.6 30 5.2 0.4 3.6 3 0 0 3 3 3 0 Ctr copper transporter family DUF4770 PF15994.5 CDI87059.1 - 0.8 9.9 25.9 3.4 7.9 0.4 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4770) Rsc14 PF08586.10 CDI87059.1 - 0.97 10.3 18.2 2.7 8.9 1.2 3.6 3 0 0 3 3 3 0 RSC complex, Rsc14/Ldb7 subunit Rxt3 PF08642.10 CDI87059.1 - 1.4 9.7 11.8 22 5.8 2.5 3.5 3 0 0 3 3 3 0 Histone deacetylation protein Rxt3 EOS1 PF12326.8 CDI87059.1 - 1.4 8.8 8.0 40 4.1 1.2 3.3 3 0 0 3 3 3 0 N-glycosylation protein PAP_RNA-bind PF04926.15 CDI87059.1 - 2.3 7.8 8.8 16 5.0 1.4 3.2 3 0 0 3 3 3 0 Poly(A) polymerase predicted RNA binding domain DUF2407_C PF13373.6 CDI87059.1 - 2.3 8.4 5.9 18 5.5 0.1 3.5 3 0 0 3 3 3 0 DUF2407 C-terminal domain MAM33 PF02330.16 CDI87059.1 - 2.6 7.9 20.8 2.1 8.3 1.5 3.3 3 0 0 3 3 3 0 Mitochondrial glycoprotein Band_3_cyto PF07565.13 CDI87059.1 - 4 7.2 17.7 5.9 6.6 2.1 3.7 4 0 0 4 4 4 0 Band 3 cytoplasmic domain EIIBC-GUT_N PF03612.14 CDI87059.1 - 4.9 6.9 24.0 5.8 6.6 1.7 4.2 4 0 0 4 4 4 0 Sorbitol phosphotransferase enzyme II N-terminus ABC_membrane PF00664.23 CDI87060.1 - 1.2e-81 274.4 20.3 8.3e-50 169.9 7.3 3.3 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 CDI87060.1 - 1.9e-48 164.4 0.0 1.2e-28 100.3 0.0 3.3 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CDI87060.1 - 5e-14 52.3 1.8 1.2e-06 28.1 1.0 3.1 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 CDI87060.1 - 1e-05 24.5 0.4 0.11 11.3 0.0 2.5 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 CDI87060.1 - 7.7e-05 23.0 0.3 0.14 12.4 0.1 3.2 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.6 CDI87060.1 - 0.00057 20.1 5.9 0.81 10.0 0.3 4.7 3 2 0 3 3 3 2 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 CDI87060.1 - 0.00077 19.9 1.6 0.0045 17.4 1.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 CDI87060.1 - 0.002 17.8 0.1 0.51 9.9 0.0 3.3 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 CDI87060.1 - 0.0074 16.2 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA PF00004.29 CDI87060.1 - 0.01 16.2 3.2 5 7.6 0.0 3.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 CDI87060.1 - 0.012 15.4 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 CDI87060.1 - 0.014 15.1 0.0 0.032 14.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 CDI87060.1 - 0.016 14.7 0.1 0.29 10.6 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_21 PF13304.6 CDI87060.1 - 0.018 14.8 0.0 1.2 8.8 0.0 2.9 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 CDI87060.1 - 0.042 13.8 0.0 0.13 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 CDI87060.1 - 0.052 13.3 2.0 6.5 6.5 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein NB-ARC PF00931.22 CDI87060.1 - 0.11 11.6 0.0 0.72 9.0 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain MoaE PF02391.17 CDI87060.1 - 0.13 12.6 4.4 4.4 7.6 0.5 3.0 2 1 1 3 3 3 0 MoaE protein TniB PF05621.11 CDI87060.1 - 0.16 11.4 0.2 4.5 6.7 0.0 2.8 3 0 0 3 3 3 0 Bacterial TniB protein G-alpha PF00503.20 CDI87060.1 - 0.22 10.6 0.0 0.4 9.8 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit CTD PF12815.7 CDI87061.1 - 0.05 14.2 2.4 0.075 13.6 2.4 1.4 1 0 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 WTX PF09422.10 CDI87061.1 - 5.2 6.0 28.2 5.8 5.9 28.2 1.0 1 0 0 1 1 1 0 WTX protein GNT-I PF03071.15 CDI87062.1 - 0.098 11.4 10.4 0.14 10.9 10.4 1.2 1 0 0 1 1 1 0 GNT-I family SMYLE_N PF18615.1 CDI87062.1 - 0.29 10.6 26.0 0.37 10.3 26.0 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain RAP1 PF07218.11 CDI87062.1 - 0.81 7.9 21.6 0.96 7.7 21.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) FUSC PF04632.12 CDI87062.1 - 0.86 8.1 6.9 1 7.8 6.9 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family MCU PF04678.13 CDI87062.1 - 0.98 9.5 9.3 1.1 9.3 9.3 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter SDA1 PF05285.12 CDI87062.1 - 1.5 8.1 22.5 1.8 7.9 22.5 1.0 1 0 0 1 1 1 0 SDA1 FAM199X PF15814.5 CDI87062.1 - 1.8 7.5 32.8 2.7 7.0 32.8 1.3 1 0 0 1 1 1 0 Protein family FAM199X DUF853 PF05872.12 CDI87062.1 - 1.9 7.0 13.5 2 6.9 13.5 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) XRCC4 PF06632.12 CDI87062.1 - 2.8 6.7 27.0 3.5 6.4 27.0 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 TFIIA PF03153.13 CDI87062.1 - 3.1 7.7 54.6 5.2 7.0 54.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hid1 PF12722.7 CDI87062.1 - 4.3 5.3 38.9 4.7 5.2 38.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1387 PF07139.11 CDI87062.1 - 7.4 6.2 36.7 8.7 6.0 36.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) SprA-related PF12118.8 CDI87062.1 - 8.6 5.4 54.1 11 5.0 54.1 1.0 1 0 0 1 1 1 0 SprA-related family TFB6 PF17110.5 CDI87062.1 - 9.7 5.9 17.8 0.67 9.7 12.2 1.7 1 1 1 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Senescence_reg PF04520.13 CDI87063.1 - 0.088 13.6 3.1 0.15 12.9 3.1 1.3 1 0 0 1 1 1 0 Senescence regulator ATP-synt_S1 PF05827.12 CDI87063.1 - 0.19 11.5 1.2 0.3 10.9 1.2 1.2 1 0 0 1 1 1 0 Vacuolar ATP synthase subunit S1 (ATP6S1) SR-25 PF10500.9 CDI87063.1 - 0.25 11.0 10.7 0.39 10.3 10.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MRI PF15325.6 CDI87063.1 - 1.6 9.9 6.9 0.32 12.1 2.7 1.9 2 0 0 2 2 2 0 Modulator of retrovirus infection RskA PF10099.9 CDI87064.1 - 0.0013 19.1 45.9 0.049 13.9 21.8 2.0 1 1 1 2 2 2 2 Anti-sigma-K factor rskA DivIC PF04977.15 CDI87064.1 - 0.021 14.6 30.2 0.39 10.5 9.4 2.2 2 0 0 2 2 2 0 Septum formation initiator EphA2_TM PF14575.6 CDI87064.1 - 0.037 14.9 6.6 2.1 9.3 0.6 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4010 PF13194.6 CDI87064.1 - 0.21 11.3 6.1 5.9 6.5 3.3 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4010) Myc_N PF01056.18 CDI87064.1 - 0.26 11.1 17.1 0.33 10.8 17.1 1.0 1 0 0 1 1 1 0 Myc amino-terminal region PepSY_2 PF13670.6 CDI87064.1 - 0.3 11.1 31.1 1.2 9.2 10.3 2.4 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain M-inducer_phosp PF06617.13 CDI87064.1 - 0.47 9.7 13.0 0.64 9.3 13.0 1.2 1 0 0 1 1 1 0 M-phase inducer phosphatase SLC12 PF03522.15 CDI87064.1 - 1.1 8.3 20.4 1.2 8.1 20.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 TMEM51 PF15345.6 CDI87064.1 - 1.1 9.0 26.7 0.038 13.8 7.9 2.0 2 0 0 2 2 2 0 Transmembrane protein 51 DUF2681 PF10883.8 CDI87064.1 - 1.8 9.0 39.3 2.6 8.5 15.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Ndc1_Nup PF09531.10 CDI87064.1 - 1.9 7.1 28.6 2.2 6.9 28.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3824 PF12868.7 CDI87064.1 - 2.4 8.8 29.0 12 6.5 10.6 2.2 1 1 1 2 2 2 0 Domain of unknwon function (DUF3824) Presenilin PF01080.17 CDI87064.1 - 2.5 6.8 26.7 3.4 6.3 26.7 1.2 1 0 0 1 1 1 0 Presenilin CbiD PF01888.17 CDI87064.1 - 3.4 6.9 16.9 0.36 10.1 2.7 2.2 2 0 0 2 2 2 0 CbiD DUF5383 PF17355.2 CDI87064.1 - 4 7.8 18.5 6 7.3 17.8 1.6 1 1 1 2 2 2 0 Family of unknown function (DUF5383) LapA_dom PF06305.11 CDI87064.1 - 4.7 7.1 13.6 7.5 6.5 2.9 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain SAGA-Tad1 PF12767.7 CDI87064.1 - 5.3 6.7 16.9 7.5 6.2 16.9 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Coilin_N PF15862.5 CDI87064.1 - 5.4 6.8 26.0 3.6 7.4 9.3 2.2 2 0 0 2 2 2 0 Coilin N-terminus Med15 PF09606.10 CDI87064.1 - 7.8 5.1 55.8 9.8 4.7 55.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3357 PF11837.8 CDI87064.1 - 7.9 7.0 13.4 8.9 6.8 3.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) DUF2722 PF10846.8 CDI87065.1 - 0.033 13.2 1.4 0.052 12.5 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Shadoo PF14999.6 CDI87065.1 - 0.042 13.9 0.4 0.042 13.9 0.4 5.4 3 1 2 5 5 5 0 Shadow of prion protein, neuroprotective Spt20 PF12090.8 CDI87065.1 - 0.76 9.3 15.5 0.25 10.9 12.3 1.8 2 0 0 2 2 2 0 Spt20 family SprA-related PF12118.8 CDI87066.1 - 3.3e-05 23.2 31.7 4.3e-05 22.8 31.7 1.1 1 0 0 1 1 1 1 SprA-related family Nop53 PF07767.11 CDI87066.1 - 0.0051 16.2 23.3 0.005 16.3 23.3 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DUF4962 PF16332.5 CDI87066.1 - 0.0099 14.4 8.1 0.012 14.1 8.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4962) Rrn6 PF10214.9 CDI87066.1 - 0.011 14.2 22.8 0.013 14.0 22.8 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SLC12 PF03522.15 CDI87066.1 - 0.026 13.6 14.1 0.026 13.6 14.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 TFIIA PF03153.13 CDI87066.1 - 0.036 14.1 46.5 0.06 13.3 46.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 CDI87066.1 - 0.038 13.0 16.0 0.04 12.9 16.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RR_TM4-6 PF06459.12 CDI87066.1 - 0.04 13.8 19.5 0.047 13.5 19.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PA26 PF04636.13 CDI87066.1 - 0.054 12.4 11.3 0.058 12.3 11.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SID-1_RNA_chan PF13965.6 CDI87066.1 - 0.056 11.8 4.6 0.058 11.8 4.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GAGA_bind PF06217.12 CDI87066.1 - 0.058 13.7 11.8 0.057 13.7 11.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Hamartin PF04388.12 CDI87066.1 - 0.076 11.7 16.5 0.089 11.4 16.5 1.0 1 0 0 1 1 1 0 Hamartin protein Exonuc_VII_L PF02601.15 CDI87066.1 - 0.082 12.5 27.2 0.11 12.1 27.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Neur_chan_memb PF02932.16 CDI87066.1 - 0.11 12.6 12.7 0.13 12.3 12.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Serinc PF03348.15 CDI87066.1 - 0.11 11.4 6.6 0.15 10.9 6.6 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) CDC27 PF09507.10 CDI87066.1 - 0.18 11.1 24.1 0.24 10.8 24.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 BAF1_ABF1 PF04684.13 CDI87066.1 - 0.18 10.8 20.6 0.25 10.3 20.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor VIR_N PF15912.5 CDI87066.1 - 0.3 10.7 9.4 0.33 10.5 9.4 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal TCP PF03634.13 CDI87066.1 - 0.3 11.7 19.1 0.42 11.2 19.1 1.2 1 0 0 1 1 1 0 TCP family transcription factor Band_3_cyto PF07565.13 CDI87066.1 - 0.32 10.8 12.6 0.39 10.5 12.6 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Smg8_Smg9 PF10220.9 CDI87066.1 - 0.33 9.2 16.5 0.39 9.0 16.5 1.0 1 0 0 1 1 1 0 Smg8_Smg9 LMBR1 PF04791.16 CDI87066.1 - 0.51 9.2 9.8 0.53 9.1 9.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Nucleoside_tran PF01733.18 CDI87066.1 - 0.72 9.2 3.0 0.86 8.9 3.0 1.3 1 0 0 1 1 1 0 Nucleoside transporter Med15 PF09606.10 CDI87066.1 - 0.72 8.5 38.5 1 8.0 38.5 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Hid1 PF12722.7 CDI87066.1 - 0.83 7.7 13.7 0.84 7.7 13.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PAT1 PF09770.9 CDI87066.1 - 1 7.6 30.6 1 7.6 30.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SpoIIIAH PF12685.7 CDI87066.1 - 1.9 8.2 26.0 2.3 8.0 26.0 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Paramyxo_ncap PF00973.19 CDI87066.1 - 2.1 7.2 11.2 2.1 7.2 11.2 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein NEMP PF10225.9 CDI87066.1 - 2.2 7.9 7.3 3.5 7.2 7.3 1.3 1 0 0 1 1 1 0 NEMP family FapA PF03961.13 CDI87066.1 - 3.4 6.2 13.4 4.1 5.9 13.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A CSG2 PF16965.5 CDI87066.1 - 4.8 6.0 12.6 6.2 5.6 12.6 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator YfhO PF09586.10 CDI87066.1 - 8.9 4.4 10.4 8.8 4.4 10.4 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO TFIIA PF03153.13 CDI87067.1 - 1.9 8.4 59.2 2 8.3 59.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PP2C PF00481.21 CDI87068.1 - 1.6e-13 50.9 0.9 1.6e-13 50.9 0.9 4.4 5 1 0 5 5 5 1 Protein phosphatase 2C RskA PF10099.9 CDI87068.1 - 5.8e-05 23.5 3.8 5.8e-05 23.5 3.8 18.0 6 4 5 11 11 11 3 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI87068.1 - 0.0012 18.5 17.2 0.0012 18.5 17.2 16.2 9 4 6 15 15 15 5 Nuclear RNA-splicing-associated protein Cytochrom_B_N_2 PF13631.6 CDI87069.1 - 1.6 8.7 7.0 77 3.2 0.0 5.4 7 0 0 7 7 7 0 Cytochrome b(N-terminal)/b6/petB Herpes_VP19C PF03327.14 CDI87070.1 - 0.004 16.7 0.1 0.0056 16.2 0.1 1.2 1 0 0 1 1 1 1 Herpesvirus capsid shell protein VP19C Hydrolase_4 PF12146.8 CDI87072.1 - 1.1e-06 28.1 0.6 1.1e-06 28.1 0.6 3.2 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDI87072.1 - 5.9e-05 23.8 7.7 0.00012 22.8 0.2 3.3 1 1 1 2 2 2 1 Alpha/beta hydrolase family RskA PF10099.9 CDI87072.1 - 0.0034 17.7 1.4 0.0034 17.7 1.4 9.7 4 3 3 7 7 7 2 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI87072.1 - 0.0085 16.1 18.5 0.0085 16.1 18.5 4.5 3 1 1 4 4 4 2 Transcription factor IIA, alpha/beta subunit Lipase_GDSL PF00657.22 CDI87072.1 - 0.064 13.2 0.8 15 5.4 0.1 3.0 3 0 0 3 3 3 0 GDSL-like Lipase/Acylhydrolase Gly_rich PF12810.7 CDI87072.1 - 5.7 6.8 10.5 1.4 8.8 2.1 2.8 2 0 0 2 2 2 0 Glycine rich protein Suf PF05843.14 CDI87073.1 - 0.00095 19.2 6.5 0.00095 19.2 6.5 3.2 3 0 0 3 3 3 1 Suppressor of forked protein (Suf) Connexin PF00029.19 CDI87073.1 - 0.00099 18.9 0.8 0.00099 18.9 0.8 1.7 2 0 0 2 2 2 1 Connexin SprA-related PF12118.8 CDI87073.1 - 0.0024 17.1 18.6 0.0024 17.1 18.6 3.8 3 1 1 4 4 3 1 SprA-related family CSG2 PF16965.5 CDI87073.1 - 0.005 15.8 0.7 0.005 15.8 0.7 2.0 2 0 0 2 2 2 1 Ceramide synthase regulator SpoIIP PF07454.11 CDI87073.1 - 0.01 15.3 0.5 0.01 15.3 0.5 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) LMBR1 PF04791.16 CDI87073.1 - 0.022 13.7 0.1 0.022 13.7 0.1 1.4 2 0 0 2 2 2 0 LMBR1-like membrane protein RPA43_OB PF17875.1 CDI87073.1 - 0.04 14.5 3.1 1.6 9.4 0.1 2.6 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I 60KD_IMP PF02096.20 CDI87073.1 - 0.046 13.6 5.6 0.097 12.6 5.6 1.5 1 0 0 1 1 1 0 60Kd inner membrane protein Orf78 PF06024.12 CDI87073.1 - 0.071 13.4 0.2 0.071 13.4 0.2 2.5 2 0 0 2 2 2 0 Orf78 (ac78) Eapp_C PF10238.9 CDI87073.1 - 2.5 8.2 9.9 0.079 13.0 1.1 2.5 2 0 0 2 2 2 0 E2F-associated phosphoprotein Cyt_bd_oxida_II PF02322.15 CDI87073.1 - 4.3 6.6 11.6 1.3 8.3 8.1 1.7 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II Zip PF02535.22 CDI87073.1 - 4.7 6.3 9.1 0.96 8.6 0.2 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter TERB2 PF15101.6 CDI87073.1 - 5.6 7.0 20.5 0.22 11.5 8.0 2.6 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Plasmodium_Vir PF05795.11 CDI87073.1 - 6.5 6.1 14.4 0.036 13.5 5.0 2.0 2 1 0 2 2 2 0 Plasmodium vivax Vir protein EOS1 PF12326.8 CDI87073.1 - 8.6 6.3 8.5 1 9.2 0.2 2.5 2 0 0 2 2 2 0 N-glycosylation protein Porphobil_deam PF01379.20 CDI87074.1 - 4.9e-20 71.9 22.4 4.3e-10 39.4 7.2 4.4 1 1 1 3 3 3 3 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 CDI87074.1 - 3.1e-13 49.9 0.2 4.2e-12 46.3 0.0 2.8 2 1 0 2 2 1 1 Porphobilinogen deaminase, C-terminal domain DUF2722 PF10846.8 CDI87074.1 - 2.7e-06 26.6 37.4 0.00097 18.2 14.2 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF2722) Peptidase_S49_N PF08496.10 CDI87074.1 - 0.00011 22.3 10.5 0.017 15.2 2.6 3.0 3 0 0 3 3 3 2 Peptidase family S49 N-terminal Ribosomal_60s PF00428.19 CDI87074.1 - 0.0038 17.8 3.1 0.0038 17.8 3.1 8.6 7 2 1 8 8 6 1 60s Acidic ribosomal protein RNase_H2_suC PF08615.11 CDI87074.1 - 0.0052 17.0 1.2 0.41 10.8 0.1 2.5 2 0 0 2 2 2 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) TERB2 PF15101.6 CDI87074.1 - 0.0074 16.4 2.8 0.0074 16.4 2.8 3.0 4 0 0 4 4 3 1 Telomere-associated protein TERB2 cwf18 PF08315.12 CDI87074.1 - 0.009 16.7 2.8 0.009 16.7 2.8 3.8 4 1 0 4 4 2 1 cwf18 pre-mRNA splicing factor V_ATPase_I PF01496.19 CDI87074.1 - 0.026 12.5 10.8 0.19 9.6 2.5 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Activator_LAG-3 PF11498.8 CDI87074.1 - 0.032 13.2 63.8 0.26 10.2 27.3 3.3 3 0 0 3 3 3 0 Transcriptional activator LAG-3 Connexin PF00029.19 CDI87074.1 - 0.14 11.9 2.7 1.9 8.2 0.3 2.3 2 0 0 2 2 2 0 Connexin BRF1 PF07741.13 CDI87074.1 - 0.15 12.4 13.7 0.4 11.0 1.8 3.5 3 0 0 3 3 3 0 Brf1-like TBP-binding domain DUF572 PF04502.13 CDI87074.1 - 0.24 11.0 16.3 0.72 9.4 3.9 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) eIF-3_zeta PF05091.12 CDI87074.1 - 0.29 10.1 16.3 0.54 9.2 6.8 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Eapp_C PF10238.9 CDI87074.1 - 0.33 11.0 11.7 0.62 10.1 2.0 3.0 3 0 0 3 3 2 0 E2F-associated phosphoprotein DUF4770 PF15994.5 CDI87074.1 - 0.52 10.5 13.6 1.5 9.0 5.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) RPA43_OB PF17875.1 CDI87074.1 - 1 10.0 6.8 4.2 8.0 1.0 2.7 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I EIIBC-GUT_N PF03612.14 CDI87074.1 - 1.2 8.9 13.3 0.92 9.2 1.9 3.2 3 0 0 3 3 3 0 Sorbitol phosphotransferase enzyme II N-terminus eIF_4EBP PF05456.11 CDI87074.1 - 1.2 9.1 15.9 0.45 10.5 2.5 2.9 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) RuvC_III PF18541.1 CDI87074.1 - 1.6 8.6 11.5 6.4 6.7 1.5 2.7 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 OmpH PF03938.14 CDI87074.1 - 1.7 8.9 58.1 3.1 8.1 24.0 3.6 3 1 0 3 3 3 0 Outer membrane protein (OmpH-like) Dpy19 PF10034.9 CDI87074.1 - 2 6.5 3.0 15 3.6 0.2 2.1 2 0 0 2 2 2 0 Q-cell neuroblast polarisation ARF7EP_C PF14949.6 CDI87074.1 - 2.2 9.0 10.2 7.6 7.2 3.2 2.7 2 0 0 2 2 2 0 ARF7 effector protein C-terminus FAM176 PF14851.6 CDI87074.1 - 3.6 7.2 7.2 2.5 7.8 0.4 2.8 3 0 0 3 3 2 0 FAM176 family RabGAP-TBC PF00566.18 CDI87074.1 - 4.4 6.9 10.6 8.8 5.9 1.0 2.2 2 0 0 2 2 2 0 Rab-GTPase-TBC domain NPR1_interact PF15699.5 CDI87074.1 - 4.5 7.9 19.4 1.5 9.5 5.3 3.2 3 0 0 3 3 3 0 NPR1 interacting EOS1 PF12326.8 CDI87074.1 - 4.8 7.1 10.9 22 4.9 0.2 2.6 2 1 0 2 2 2 0 N-glycosylation protein MRP-S26 PF14943.6 CDI87074.1 - 5.5 6.9 14.7 4.5 7.2 4.2 2.5 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 ANAPC_CDC26 PF10471.9 CDI87074.1 - 5.8 7.8 59.8 0.071 13.9 18.5 4.8 5 0 0 5 5 4 0 Anaphase-promoting complex APC subunit CDC26 EIF4E-T PF10477.9 CDI87074.1 - 6.5 5.4 33.2 0.13 11.0 10.1 2.4 3 0 0 3 3 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF3381 PF11861.8 CDI87074.1 - 6.6 6.5 17.9 2 8.2 0.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) MH2 PF03166.14 CDI87074.1 - 6.8 6.9 7.8 7.6 6.7 0.6 2.6 3 0 0 3 3 2 0 MH2 domain Plasmodium_Vir PF05795.11 CDI87074.1 - 7 6.0 9.0 8.4 5.7 2.0 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Rsc14 PF08586.10 CDI87074.1 - 7.2 7.5 10.1 22 6.0 1.9 2.7 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit RRP36 PF06102.12 CDI87074.1 - 7.3 6.5 17.7 11 5.9 6.3 2.5 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 DUF5523 PF17661.1 CDI87074.1 - 8.3 6.0 15.8 9.1 5.9 3.7 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) ATAD4 PF15321.6 CDI87074.1 - 9.6 7.6 12.1 8.1 7.9 0.4 3.6 4 0 0 4 4 3 0 ATPase family AAA domain containing 4 PAP1 PF08601.10 CDI87074.1 - 9.8 5.8 20.0 6.4 6.4 12.3 2.5 2 0 0 2 2 2 0 Transcription factor PAP1 Spt20 PF12090.8 CDI87075.1 - 7.6e-06 25.7 16.6 7.6e-06 25.7 16.6 7.2 6 1 1 7 7 7 3 Spt20 family TFIIA PF03153.13 CDI87075.1 - 5.4e-05 23.4 35.8 8.7e-05 22.7 19.6 4.6 3 1 1 4 4 4 2 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI87075.1 - 5.6e-05 22.3 7.8 5.6e-05 22.3 7.8 6.6 6 1 1 7 7 7 3 Protein of unknown function (DUF2722) Utp14 PF04615.13 CDI87075.1 - 0.0085 14.7 51.3 0.013 14.1 19.8 3.2 3 0 0 3 3 3 3 Utp14 protein PEX11 PF05648.14 CDI87075.1 - 0.016 14.7 0.8 0.016 14.7 0.8 5.1 5 0 0 5 5 5 0 Peroxisomal biogenesis factor 11 (PEX11) Polysacc_synt_2 PF02719.15 CDI87075.1 - 0.93 8.6 8.8 0.054 12.6 1.5 2.5 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein HNOBA PF07701.14 CDI87075.1 - 1.4 8.3 33.8 2 7.8 0.7 5.2 5 0 0 5 5 5 0 Heme NO binding associated Ribosomal_L5e PF17144.4 CDI87076.1 - 5e-45 153.4 0.0 5e-45 153.4 0.0 1.8 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 CDI87076.1 - 6e-31 107.2 7.7 8.3e-31 106.8 7.7 1.2 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region DUF885 PF05960.11 CDI87076.1 - 0.064 12.9 0.6 0.087 12.5 0.6 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Choline_sulf_C PF12411.8 CDI87076.1 - 0.064 13.1 0.7 3.4 7.6 0.1 2.5 2 0 0 2 2 2 0 Choline sulfatase enzyme C terminal VitK2_biosynth PF02621.14 CDI87076.1 - 0.067 12.7 0.9 0.13 11.7 0.6 1.6 1 1 0 1 1 1 0 Menaquinone biosynthesis Sod_Ni PF09055.11 CDI87076.1 - 0.56 10.8 3.1 2.4 8.7 1.5 2.0 1 1 1 2 2 2 0 Nickel-containing superoxide dismutase Ephrin_rec_like PF07699.13 CDI87078.1 - 5.1e-20 71.0 117.5 1e-07 31.6 4.6 11.1 12 0 0 12 12 12 8 Putative ephrin-receptor like PAN_4 PF14295.6 CDI87078.1 - 0.0053 16.6 1.0 0.026 14.4 0.2 2.7 2 0 0 2 2 2 1 PAN domain Uso1_p115_C PF04871.13 CDI87078.1 - 0.041 14.3 4.5 0.085 13.2 4.5 1.5 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region HALZ PF02183.18 CDI87078.1 - 0.091 13.0 0.9 0.19 12.0 0.9 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper AAA_13 PF13166.6 CDI87078.1 - 0.2 10.3 0.9 0.27 9.8 0.9 1.1 1 0 0 1 1 1 0 AAA domain Amino_oxidase PF01593.24 CDI87079.1 - 8.1e-37 127.6 0.4 3.4e-26 92.6 0.0 2.6 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDI87079.1 - 2.7e-12 46.7 0.3 2.7e-12 46.7 0.3 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CDI87079.1 - 4.3e-06 26.1 3.8 8.3e-06 25.1 3.8 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CDI87079.1 - 4.9e-06 26.4 0.1 1.7e-05 24.6 0.1 1.9 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDI87079.1 - 7.7e-06 25.3 0.4 1.6e-05 24.3 0.4 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDI87079.1 - 2.3e-05 24.0 0.8 2.3e-05 24.0 0.8 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CDI87079.1 - 0.00031 20.1 0.7 0.00063 19.1 0.7 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CDI87079.1 - 0.00069 18.9 0.1 0.0015 17.8 0.1 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 CDI87079.1 - 0.0013 19.3 0.2 0.0029 18.1 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDI87079.1 - 0.0051 15.6 0.8 0.0051 15.6 0.8 2.3 2 0 0 2 2 2 1 HI0933-like protein PHD PF00628.29 CDI87079.1 - 0.014 15.2 3.6 0.016 15.1 0.5 2.5 2 0 0 2 2 2 0 PHD-finger zf-RING_2 PF13639.6 CDI87079.1 - 0.64 10.4 7.2 0.062 13.6 1.5 2.4 2 0 0 2 2 2 0 Ring finger domain PRP1_N PF06424.12 CDI87080.1 - 6.5e-51 172.6 8.3 4.8e-42 143.8 5.3 2.8 2 1 0 2 2 2 2 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 CDI87080.1 - 4.3e-26 89.4 39.6 0.0011 19.6 0.5 14.9 8 3 9 17 17 15 8 Tetratricopeptide repeat TPR_19 PF14559.6 CDI87080.1 - 3.2e-19 69.2 16.1 0.00097 19.6 0.3 9.1 6 3 2 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDI87080.1 - 2e-07 31.5 15.1 0.00049 20.7 0.0 8.4 9 1 0 9 9 9 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDI87080.1 - 3.1e-07 30.0 13.5 5 7.5 0.2 10.3 13 0 0 13 13 12 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDI87080.1 - 2.5e-06 27.2 2.6 12 6.4 0.0 8.1 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDI87080.1 - 5.1e-05 22.9 0.0 1.7 8.4 0.0 4.8 5 0 0 5 5 5 2 TPR repeat ChAPs PF09295.10 CDI87080.1 - 0.00018 20.7 7.7 0.029 13.4 0.1 4.0 2 1 2 4 4 4 2 ChAPs (Chs5p-Arf1p-binding proteins) ANAPC3 PF12895.7 CDI87080.1 - 0.0011 19.2 7.3 0.42 10.9 0.3 5.1 4 2 0 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 CDI87080.1 - 0.0017 18.6 9.5 2.8 8.5 0.0 8.8 12 3 2 14 14 10 1 Tetratricopeptide repeat Suf PF05843.14 CDI87080.1 - 0.0027 17.8 0.0 8.4 6.3 0.1 4.5 3 3 0 3 3 3 1 Suppressor of forked protein (Suf) TPR_12 PF13424.6 CDI87080.1 - 0.0027 18.0 11.8 1.4 9.3 0.1 6.8 7 1 0 7 7 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDI87080.1 - 0.0052 16.9 7.5 0.47 10.6 0.1 5.4 4 1 2 6 6 6 1 Tetratricopeptide repeat DUF3808 PF10300.9 CDI87080.1 - 0.0066 15.2 2.0 0.62 8.7 0.1 3.9 4 1 1 5 5 5 1 Protein of unknown function (DUF3808) TPR_6 PF13174.6 CDI87080.1 - 0.054 14.1 13.2 31 5.5 0.0 7.7 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_21 PF09976.9 CDI87080.1 - 0.055 13.2 17.2 0.045 13.5 5.1 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat-like domain TPR_1 PF00515.28 CDI87080.1 - 0.33 10.9 1.7 3.4 7.6 0.0 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat Tho2 PF11262.8 CDI87080.1 - 0.76 8.9 4.7 0.52 9.5 1.7 2.2 3 0 0 3 3 3 0 Transcription factor/nuclear export subunit protein 2 SCAN PF02023.17 CDI87080.1 - 3.3 7.6 7.4 4.1 7.3 0.1 3.9 3 1 1 4 4 3 0 SCAN domain YebG PF07130.12 CDI87081.1 - 0.0088 15.9 0.3 0.024 14.5 0.3 1.7 1 0 0 1 1 1 1 YebG protein YscO PF07321.12 CDI87081.1 - 1.7 8.6 5.8 6.7 6.7 1.1 2.5 1 1 1 2 2 2 0 Type III secretion protein YscO Apolipoprotein PF01442.18 CDI87081.1 - 5.6 6.8 8.8 39 4.1 8.8 2.3 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain WD40_4 PF16300.5 CDI87082.1 - 7.3e-19 67.4 0.0 1.4e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 CDI87082.1 - 8.9e-12 45.4 0.4 9.9e-07 29.4 0.0 3.8 4 0 0 4 4 3 2 WD domain, G-beta repeat DUF1899 PF08953.11 CDI87082.1 - 1.2e-06 28.2 0.0 2.4e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 CDI87082.1 - 2.4e-06 27.8 0.0 0.19 12.0 0.0 4.4 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain ABC_tran_CTD PF16326.5 CDI87082.1 - 0.0002 21.5 25.1 0.074 13.3 7.5 4.4 1 1 3 4 4 4 3 ABC transporter C-terminal domain TolA_bind_tri PF16331.5 CDI87082.1 - 0.00043 20.3 22.0 0.21 11.7 4.0 3.3 2 1 1 3 3 3 3 TolA binding protein trimerisation Baculo_PEP_C PF04513.12 CDI87082.1 - 0.0016 18.5 6.8 0.017 15.2 0.5 2.4 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF812 PF05667.11 CDI87082.1 - 0.0025 16.8 16.7 0.0036 16.3 16.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Exonuc_VII_L PF02601.15 CDI87082.1 - 0.0033 17.1 7.5 0.0052 16.4 7.5 1.4 1 0 0 1 1 1 1 Exonuclease VII, large subunit BLOC1_2 PF10046.9 CDI87082.1 - 0.0089 16.3 17.2 0.4 11.0 2.0 2.8 1 1 0 2 2 2 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tropomyosin_1 PF12718.7 CDI87082.1 - 0.016 15.4 28.6 0.26 11.4 29.2 2.0 1 1 1 2 2 2 0 Tropomyosin like Shugoshin_N PF07558.11 CDI87082.1 - 0.03 14.2 5.7 1 9.3 0.2 3.8 3 1 0 4 4 4 0 Shugoshin N-terminal coiled-coil region DUF5082 PF16888.5 CDI87082.1 - 0.079 13.2 16.0 0.15 12.4 16.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) Ge1_WD40 PF16529.5 CDI87082.1 - 0.12 11.3 0.0 1.4 7.8 0.0 2.4 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RPW8 PF05659.11 CDI87082.1 - 0.14 11.8 6.5 0.41 10.3 1.6 2.4 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Jnk-SapK_ap_N PF09744.9 CDI87082.1 - 0.18 12.0 24.9 0.83 9.9 8.4 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF724 PF05266.14 CDI87082.1 - 0.31 10.9 17.7 0.088 12.6 13.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF4407 PF14362.6 CDI87082.1 - 0.53 9.6 17.8 0.8 9.0 17.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fmp27_WPPW PF10359.9 CDI87082.1 - 0.71 8.7 12.0 1.1 8.0 12.0 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain GAS PF13851.6 CDI87082.1 - 0.83 9.0 25.9 2.2 7.6 25.4 1.8 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 CDI87082.1 - 0.85 9.6 24.4 0.85 9.6 22.7 1.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 CDI87082.1 - 0.94 9.6 28.7 0.65 10.1 11.4 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein FH2 PF02181.23 CDI87082.1 - 1 8.4 16.1 0.11 11.6 8.7 2.1 1 1 1 2 2 2 0 Formin Homology 2 Domain Phage_GP20 PF06810.11 CDI87082.1 - 1.2 8.9 22.5 0.92 9.3 8.1 3.1 1 1 1 2 2 2 0 Phage minor structural protein GP20 Lebercilin PF15619.6 CDI87082.1 - 1.5 8.5 25.3 3.9 7.1 25.3 1.7 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease SKA1 PF07160.12 CDI87082.1 - 1.5 8.6 16.7 4.6 7.0 16.7 1.7 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 MCC-bdg_PDZ PF10506.9 CDI87082.1 - 2.1 8.4 14.6 6.8 6.8 1.1 3.5 2 1 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Med4 PF10018.9 CDI87082.1 - 2.6 7.7 16.7 0.61 9.7 1.4 2.3 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 SpecificRecomb PF10136.9 CDI87082.1 - 2.6 6.2 7.4 3.7 5.7 7.4 1.1 1 0 0 1 1 1 0 Site-specific recombinase DUF4600 PF15372.6 CDI87082.1 - 4.1 7.8 17.2 37 4.8 0.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) Pkip-1 PF06878.11 CDI87082.1 - 4.4 7.4 13.0 28 4.8 6.8 3.1 1 1 1 2 2 2 0 Pkip-1 protein Spc7 PF08317.11 CDI87082.1 - 5.8 5.7 27.5 1.7 7.5 17.0 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Fib_alpha PF08702.10 CDI87082.1 - 6.4 7.0 14.6 4.5 7.5 8.3 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family HalX PF08663.10 CDI87082.1 - 6.7 7.1 12.1 4 7.8 0.7 4.0 1 1 2 3 3 3 0 HalX domain Mod_r PF07200.13 CDI87082.1 - 8 6.6 23.4 2.7 8.1 10.3 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein WXG100 PF06013.12 CDI87082.1 - 8.7 6.7 14.6 1.1 9.5 6.4 2.8 1 1 2 3 3 3 0 Proteins of 100 residues with WXG HemX PF04375.14 CDI87082.1 - 9.5 5.4 25.4 7 5.8 10.4 2.1 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Cluap1 PF10234.9 CDI87083.1 - 0.029 13.8 4.7 0.019 14.4 3.1 1.5 2 0 0 2 2 2 0 Clusterin-associated protein-1 APG6_N PF17675.1 CDI87083.1 - 0.21 12.1 7.4 0.58 10.7 7.4 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region Syntaxin_2 PF14523.6 CDI87083.1 - 1.8 9.0 6.1 0.48 10.8 1.5 2.3 2 0 0 2 2 2 0 Syntaxin-like protein DUF4140 PF13600.6 CDI87083.1 - 2.3 8.7 9.7 13 6.3 4.9 2.9 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) BST2 PF16716.5 CDI87083.1 - 5 7.8 8.7 29 5.3 4.7 2.6 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 DivIC PF04977.15 CDI87083.1 - 7.3 6.4 7.3 5 7.0 5.3 1.8 1 1 0 1 1 1 0 Septum formation initiator WD40 PF00400.32 CDI87084.1 - 4.4e-12 46.3 6.3 0.092 13.7 0.1 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI87084.1 - 0.0041 17.4 0.1 2.7 8.4 0.0 4.0 5 0 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain V-ATPase_G PF03179.15 CDI87085.1 - 6.8e-25 87.6 7.7 8e-25 87.4 7.7 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit HrpE PF06188.12 CDI87085.1 - 0.01 15.7 1.5 0.022 14.6 1.5 1.4 1 1 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E ADPrib_exo_Tox PF03496.14 CDI87085.1 - 0.048 13.0 0.3 0.05 12.9 0.3 1.1 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme ATP-synt_B PF00430.18 CDI87085.1 - 0.082 13.0 10.4 0.054 13.6 8.6 1.5 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) PEP-utilisers_N PF05524.13 CDI87085.1 - 0.6 10.3 5.6 0.85 9.8 5.6 1.2 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal WD40 PF00400.32 CDI87086.1 - 3.8e-26 90.8 9.8 9e-08 32.7 0.2 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI87086.1 - 6.7e-10 39.1 0.0 0.014 15.6 0.0 5.0 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDI87086.1 - 2.4e-05 23.5 1.2 0.33 9.9 0.0 3.2 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CDI87086.1 - 0.084 11.5 0.1 0.37 9.4 0.1 2.0 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 CDI87086.1 - 0.2 10.1 0.1 0.64 8.5 0.0 1.8 3 0 0 3 3 3 0 Cytochrome D1 heme domain Ribosomal_S5 PF00333.20 CDI87087.1 - 3.6e-29 100.5 0.4 8.2e-29 99.4 0.4 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 CDI87087.1 - 2.6e-23 81.2 0.0 5e-23 80.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 CDI87087.1 - 4.7 7.8 9.9 11 6.7 9.9 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Ribosomal_S17_N PF16205.5 CDI87088.1 - 2.1e-28 98.5 0.2 4.1e-28 97.5 0.2 1.5 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 CDI87088.1 - 2.2e-23 82.1 1.7 3.3e-23 81.6 1.7 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 EELM2 PF15863.5 CDI87089.1 - 2.5e-77 258.9 0.0 3.6e-77 258.3 0.0 1.2 1 0 0 1 1 1 1 Extended EGL-27 and MTA1 homology domain PHD PF00628.29 CDI87089.1 - 2.3e-08 33.8 6.6 2.3e-08 33.8 6.6 1.9 2 0 0 2 2 2 1 PHD-finger zf-PHD-like PF15446.6 CDI87089.1 - 0.011 15.3 6.0 0.089 12.4 3.1 3.0 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain POPLD PF08170.12 CDI87089.1 - 0.059 13.7 0.1 0.15 12.4 0.1 1.7 1 0 0 1 1 1 0 POPLD (NUC188) domain DUF2076 PF09849.9 CDI87090.1 - 1.3 9.0 6.4 2.2 8.2 5.2 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Nop25 PF09805.9 CDI87091.1 - 1e-12 48.7 9.8 1e-12 48.7 9.8 1.6 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) DUF5526 PF17664.1 CDI87091.1 - 2.5 7.7 13.2 0.1 12.1 7.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5526) DUF2722 PF10846.8 CDI87092.1 - 0.0008 18.5 10.9 0.0008 18.5 10.9 5.7 6 0 0 6 6 6 4 Protein of unknown function (DUF2722) PRCC PF10253.9 CDI87092.1 - 0.021 15.6 1.9 0.021 15.6 1.9 5.2 3 1 0 3 3 3 0 Mitotic checkpoint regulator, MAD2B-interacting DUF913 PF06025.12 CDI87093.1 - 2.2 7.2 10.8 2.5 7.0 10.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Vfa1 PF08432.10 CDI87093.1 - 2.7 8.3 25.5 3.6 7.9 25.5 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SLC12 PF03522.15 CDI87094.1 - 0.13 11.3 8.5 0.24 10.4 8.5 1.5 1 0 0 1 1 1 0 Solute carrier family 12 Tmemb_18A PF09771.9 CDI87097.1 - 0.18 12.2 1.1 0.33 11.3 1.1 1.4 1 0 0 1 1 1 0 Transmembrane protein 188 DUF4728 PF15860.5 CDI87097.1 - 0.3 11.8 5.1 0.82 10.4 3.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4728) His_Phos_1 PF00300.22 CDI87098.1 - 0.13 11.9 0.1 0.51 10.0 0.0 1.9 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) Pex14_N PF04695.13 CDI87099.1 - 0.001 19.7 0.2 0.033 14.8 0.0 2.6 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region MIT PF04212.18 CDI87099.1 - 0.16 12.1 0.5 0.4 10.8 0.5 1.6 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Ribosomal_L27e PF01777.18 CDI87100.1 - 5.1e-25 87.6 2.8 6.6e-25 87.3 2.8 1.1 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 CDI87100.1 - 0.0047 16.8 2.1 0.0084 16.0 2.1 1.4 1 0 0 1 1 1 1 KOW motif rRNA_proc-arch PF13234.6 CDI87100.1 - 0.084 12.8 0.0 0.085 12.8 0.0 1.2 1 0 0 1 1 1 0 rRNA-processing arch domain PARP PF00644.20 CDI87101.1 - 1.2e-52 178.3 0.0 2.1e-52 177.6 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 CDI87101.1 - 7.2e-34 116.8 2.6 1.1e-33 116.2 2.6 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 CDI87101.1 - 5.7e-11 42.3 1.9 9.7e-11 41.6 1.0 1.9 2 0 0 2 2 2 1 WGR domain PADR1 PF08063.12 CDI87101.1 - 7e-11 41.7 0.1 1.5e-10 40.7 0.1 1.6 1 0 0 1 1 1 1 PADR1 (NUC008) domain BRCT PF00533.26 CDI87101.1 - 1e-08 35.4 0.0 3e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CDI87101.1 - 6.9e-05 22.7 0.0 0.00023 21.1 0.0 1.9 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 CDI87101.1 - 0.072 13.5 0.0 0.29 11.6 0.0 2.0 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain FAM163 PF15069.6 CDI87103.1 - 1.9 9.0 4.1 2.1 8.8 0.0 2.7 3 0 0 3 3 3 0 FAM163 family GAS PF13851.6 CDI87104.1 - 0.16 11.3 9.8 0.58 9.5 9.8 2.0 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding PsaN PF05479.11 CDI87105.1 - 1.5 9.0 13.5 1.6 8.9 13.5 1.1 1 0 0 1 1 1 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) Tic110 PF16940.5 CDI87105.1 - 2.9 6.3 9.7 2.8 6.3 9.7 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF1117 PF06547.12 CDI87105.1 - 3.3 8.3 8.2 4.3 7.9 8.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1117) DUF5427 PF10310.9 CDI87106.1 - 4.4 6.2 32.1 4.8 6.0 32.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF3807 PF12720.7 CDI87106.1 - 9.7 6.4 38.5 11 6.2 38.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Ribosomal_60s PF00428.19 CDI87107.1 - 0.00044 20.8 15.5 0.00044 20.8 15.5 26.6 10 3 11 21 21 21 2 60s Acidic ribosomal protein Tetraspanin PF00335.20 CDI87107.1 - 0.0027 17.5 0.0 3.2 7.4 0.1 3.6 2 1 0 2 2 2 2 Tetraspanin family SPT6_acidic PF14632.6 CDI87108.1 - 0.037 14.6 6.4 0.037 14.6 6.4 5.2 4 2 1 5 5 5 0 Acidic N-terminal SPT6 UPF0564 PF10595.9 CDI87109.1 - 1.1e-05 24.7 14.1 1.1e-05 24.7 14.1 4.2 4 0 0 4 4 4 2 Uncharacterised protein family UPF0564 DUF2722 PF10846.8 CDI87109.1 - 0.0023 16.9 1.7 0.0023 16.9 1.7 6.3 4 2 2 6 6 6 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI87110.1 - 0.031 14.6 14.3 0.034 14.5 14.3 1.0 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Plant_all_beta PF10532.9 CDI87110.1 - 0.85 9.9 3.7 1 9.6 3.7 1.3 1 0 0 1 1 1 0 Plant specific N-all beta domain DUF5384 PF17358.2 CDI87110.1 - 1.3 9.0 21.1 1.6 8.7 21.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5384) rRNA_processing PF08524.11 CDI87110.1 - 3.7 7.6 17.9 4.5 7.3 17.9 1.0 1 0 0 1 1 1 0 rRNA processing STAC2_u1 PF16664.5 CDI87110.1 - 4.5 7.7 14.6 4.9 7.6 14.6 1.0 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 CCDC53 PF10152.9 CDI87110.1 - 7.7 6.9 19.9 9.7 6.6 19.9 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex SDA1 PF05285.12 CDI87111.1 - 1.8e-05 24.4 19.7 1.8e-05 24.4 19.7 2.1 2 0 0 2 2 2 1 SDA1 RskA PF10099.9 CDI87111.1 - 5.4e-05 23.6 60.5 20 5.4 42.6 3.7 1 1 1 2 2 2 1 Anti-sigma-K factor rskA Auxin_canalis PF05703.11 CDI87111.1 - 0.002 18.1 28.9 0.002 18.1 28.9 2.3 2 0 0 2 2 2 1 Auxin canalisation Merozoite_SPAM PF07133.11 CDI87111.1 - 0.0036 17.3 36.5 0.0036 17.3 36.5 2.1 2 0 0 2 2 2 1 Merozoite surface protein (SPAM) DUF3995 PF13160.6 CDI87111.1 - 0.44 10.9 12.3 0.79 10.1 8.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3995) DUF1772 PF08592.11 CDI87111.1 - 4.7 7.5 24.0 7.1 6.9 16.8 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) BAF1_ABF1 PF04684.13 CDI87114.1 - 6.8e-05 22.1 13.5 7.9e-05 21.9 13.5 1.0 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor OATP PF03137.20 CDI87114.1 - 0.0023 16.3 3.3 0.0034 15.7 3.3 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Zip PF02535.22 CDI87114.1 - 0.07 12.3 9.0 0.083 12.1 9.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3824 PF12868.7 CDI87114.1 - 0.07 13.8 14.9 0.033 14.9 12.8 1.5 1 1 0 1 1 1 0 Domain of unknwon function (DUF3824) Ureide_permease PF07168.11 CDI87114.1 - 0.16 10.7 4.5 0.18 10.5 4.5 1.2 1 0 0 1 1 1 0 Ureide permease SID-1_RNA_chan PF13965.6 CDI87114.1 - 0.18 10.2 4.6 0.19 10.1 4.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ADP_ribosyl_GH PF03747.14 CDI87114.1 - 0.22 11.2 2.6 0.24 11.1 2.6 1.1 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase CDC45 PF02724.14 CDI87114.1 - 0.26 9.5 13.2 0.31 9.3 13.2 1.2 1 0 0 1 1 1 0 CDC45-like protein FAM101 PF15068.6 CDI87114.1 - 0.35 10.8 7.8 0.79 9.6 7.8 1.7 1 1 0 1 1 1 0 FAM101 family Serinc PF03348.15 CDI87114.1 - 0.44 9.4 9.5 0.49 9.3 9.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) V_ATPase_I PF01496.19 CDI87114.1 - 0.64 7.9 19.3 0.68 7.8 19.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FAM60A PF15396.6 CDI87114.1 - 0.69 9.9 12.9 0.99 9.4 12.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 CDI87114.1 - 0.71 8.6 24.2 0.8 8.4 24.2 1.1 1 0 0 1 1 1 0 Presenilin O-antigen_lig PF13425.6 CDI87114.1 - 0.81 8.4 6.6 0.93 8.2 6.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DDHD PF02862.17 CDI87114.1 - 1.1 9.4 18.4 1.4 9.0 18.4 1.2 1 0 0 1 1 1 0 DDHD domain CSG2 PF16965.5 CDI87114.1 - 1.2 8.0 8.2 1.4 7.8 8.2 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator RR_TM4-6 PF06459.12 CDI87114.1 - 1.3 8.8 21.6 1.8 8.3 21.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2464 PF10240.9 CDI87114.1 - 1.4 8.5 10.9 1.6 8.2 10.9 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 DUF1345 PF07077.11 CDI87114.1 - 1.4 8.6 5.8 0.26 11.0 1.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) Claudin_2 PF13903.6 CDI87114.1 - 1.7 8.4 3.3 27 4.4 2.6 2.2 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF2052 PF09747.9 CDI87114.1 - 1.7 8.7 21.7 2.1 8.4 21.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Neur_chan_memb PF02932.16 CDI87114.1 - 2.1 8.3 16.1 2.5 8.1 16.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Nucleoside_tran PF01733.18 CDI87114.1 - 2.1 7.6 4.8 2.3 7.6 4.8 1.2 1 0 0 1 1 1 0 Nucleoside transporter DcuA_DcuB PF03605.14 CDI87114.1 - 2.2 7.1 5.8 2.6 6.8 5.8 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF4637 PF15470.6 CDI87114.1 - 2.5 7.8 13.0 0.38 10.5 9.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) DUF4050 PF13259.6 CDI87114.1 - 3.2 8.0 16.5 4.2 7.6 16.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) SLC12 PF03522.15 CDI87114.1 - 3.5 6.5 19.7 3.9 6.4 19.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SpoVR PF04293.13 CDI87114.1 - 4.3 5.9 15.5 5.3 5.6 15.5 1.1 1 0 0 1 1 1 0 SpoVR like protein Cellulose_synt PF03552.14 CDI87114.1 - 4.4 5.7 4.4 4.5 5.6 4.4 1.1 1 0 0 1 1 1 0 Cellulose synthase CCSAP PF15748.5 CDI87114.1 - 4.5 7.4 23.4 5.3 7.1 23.4 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4667 PF15700.5 CDI87114.1 - 4.5 7.3 21.9 5.7 7.0 21.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) TMEM214 PF10151.9 CDI87114.1 - 4.7 5.6 16.3 5.8 5.2 16.3 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Velvet PF11754.8 CDI87114.1 - 4.9 7.0 18.8 6.9 6.5 18.8 1.2 1 0 0 1 1 1 0 Velvet factor Pal1 PF08316.11 CDI87114.1 - 5.1 7.9 12.3 8 7.2 11.9 1.6 1 1 0 1 1 1 0 Pal1 cell morphology protein WTX PF09422.10 CDI87114.1 - 5.5 5.9 15.3 6.1 5.8 15.3 1.0 1 0 0 1 1 1 0 WTX protein SAPS PF04499.15 CDI87114.1 - 5.7 5.6 15.4 6.8 5.4 15.4 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein R_equi_Vir PF05526.11 CDI87114.1 - 5.9 6.7 9.9 8.1 6.3 9.9 1.3 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF3357 PF11837.8 CDI87114.1 - 6 7.4 7.3 15 6.1 7.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) Bac_export_2 PF01312.19 CDI87114.1 - 6.1 6.0 10.0 7.3 5.7 10.0 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family 2HCT PF03390.15 CDI87114.1 - 7.4 5.1 5.3 9 4.8 5.3 1.3 1 1 0 1 1 1 0 2-hydroxycarboxylate transporter family Smg8_Smg9 PF10220.9 CDI87114.1 - 7.6 4.7 19.2 7.9 4.7 19.2 1.0 1 0 0 1 1 1 0 Smg8_Smg9 PNISR PF15996.5 CDI87114.1 - 8.4 6.6 28.8 11 6.3 28.8 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR NPR3 PF03666.13 CDI87114.1 - 8.5 5.0 17.6 10 4.8 17.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2126 PF09899.9 CDI87114.1 - 9.5 4.2 13.9 11 4.0 13.9 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Zip PF02535.22 CDI87116.1 - 0.56 9.4 14.4 0.67 9.1 14.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter XRN_M PF17846.1 CDI87116.1 - 1.5 7.7 11.5 1.7 7.5 11.5 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Baculo_PP31 PF05311.11 CDI87116.1 - 7.4 6.0 18.3 7.4 6.0 18.3 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) FAM60A PF15396.6 CDI87116.1 - 9.2 6.2 16.1 9.8 6.1 16.1 1.0 1 0 0 1 1 1 0 Protein Family FAM60A 2HCT PF03390.15 CDI87117.1 - 0.0092 14.6 1.9 0.011 14.4 1.9 1.1 1 0 0 1 1 1 1 2-hydroxycarboxylate transporter family DUF4050 PF13259.6 CDI87117.1 - 0.035 14.4 9.6 0.045 14.1 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) MAT1 PF06391.13 CDI87117.1 - 0.044 13.6 24.4 0.058 13.2 24.4 1.3 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Zip PF02535.22 CDI87117.1 - 0.12 11.6 7.5 0.14 11.3 7.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4484 PF14831.6 CDI87117.1 - 0.15 12.0 11.4 0.17 11.9 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) DUF1345 PF07077.11 CDI87117.1 - 0.18 11.5 5.0 0.13 12.0 0.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) CSG2 PF16965.5 CDI87117.1 - 0.21 10.5 10.3 0.23 10.4 10.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator SLC12 PF03522.15 CDI87117.1 - 0.3 10.0 19.8 0.35 9.9 19.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CCSAP PF15748.5 CDI87117.1 - 0.31 11.2 15.2 0.37 10.9 15.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4820 PF16091.5 CDI87117.1 - 0.41 10.0 15.3 0.52 9.7 15.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) INSIG PF07281.12 CDI87117.1 - 0.44 10.2 2.7 0.59 9.7 2.7 1.3 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) Neur_chan_memb PF02932.16 CDI87117.1 - 0.48 10.4 15.2 0.55 10.2 15.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RuvC_III PF18541.1 CDI87117.1 - 0.62 10.0 14.9 0.24 11.3 6.1 2.0 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 DUF4064 PF13273.6 CDI87117.1 - 0.66 10.3 5.8 6.8 7.0 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Senescence_reg PF04520.13 CDI87117.1 - 0.75 10.6 8.9 0.94 10.3 8.9 1.2 1 0 0 1 1 1 0 Senescence regulator Sox_N PF12444.8 CDI87117.1 - 0.78 10.9 5.5 1.4 10.1 1.0 2.2 2 0 0 2 2 2 0 Sox developmental protein N terminal Serinc PF03348.15 CDI87117.1 - 1.4 7.7 8.3 1.9 7.3 8.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) MMR1 PF08505.10 CDI87117.1 - 1.4 9.1 22.0 1.9 8.8 22.0 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein V_ATPase_I PF01496.19 CDI87117.1 - 1.5 6.6 20.7 1.7 6.5 20.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DcuA_DcuB PF03605.14 CDI87117.1 - 2 7.3 8.2 1.3 7.8 6.8 1.4 1 1 1 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter G6B PF15096.6 CDI87117.1 - 2.6 7.8 6.3 4.2 7.1 6.2 1.4 1 1 1 2 2 2 0 G6B family CAF1 PF04857.20 CDI87117.1 - 3.9 6.6 12.1 4.9 6.2 12.1 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease XRN_M PF17846.1 CDI87117.1 - 4.2 6.2 13.3 5.2 5.9 13.3 1.1 1 0 0 1 1 1 0 Xrn1 helical domain HCO3_cotransp PF00955.21 CDI87117.1 - 6.7 5.4 9.8 8.9 5.0 9.8 1.2 1 0 0 1 1 1 0 HCO3- transporter family ALMT PF11744.8 CDI87117.1 - 7 5.4 16.6 7.1 5.3 16.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Het-C PF07217.11 CDI87117.1 - 7.1 5.0 16.1 8.3 4.8 16.1 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C O-antigen_lig PF13425.6 CDI87117.1 - 8.7 5.0 9.5 9.4 4.9 9.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein AvrE_T3Es PF11725.8 CDI87118.1 - 0.15 9.3 2.3 0.21 8.8 2.3 1.1 1 0 0 1 1 1 0 AvrE-family Type-III effector proteins (T3Es) DUF2845 PF11006.8 CDI87120.1 - 0.13 12.4 0.9 9.5 6.4 0.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2845) SUIM_assoc PF16619.5 CDI87121.1 - 5.1 7.2 34.3 0.37 10.9 8.8 3.7 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 K_channel_TID PF07941.11 CDI87122.1 - 0.0061 17.0 8.3 0.0061 17.0 8.3 24.4 17 7 6 23 23 23 2 Potassium channel Kv1.4 tandem inactivation domain DUF1754 PF08555.10 CDI87123.1 - 0.0015 19.3 4.5 0.0015 19.3 4.5 2.2 1 1 1 2 2 2 1 Eukaryotic family of unknown function (DUF1754) GREB1 PF15782.5 CDI87123.1 - 4.4 4.3 7.0 4.9 4.2 7.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CDC45 PF02724.14 CDI87124.1 - 1.5 7.0 33.2 1.8 6.8 33.2 1.0 1 0 0 1 1 1 0 CDC45-like protein WTX PF09422.10 CDI87124.1 - 6.3 5.7 22.5 7.3 5.5 22.5 1.1 1 0 0 1 1 1 0 WTX protein DUF4045 PF13254.6 CDI87124.1 - 6.8 6.2 28.8 7.7 6.1 28.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Neur_chan_memb PF02932.16 CDI87124.1 - 7.3 6.6 30.4 9 6.3 30.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RskA PF10099.9 CDI87125.1 - 2.4e-08 34.5 15.8 5e-05 23.7 0.0 7.0 1 1 4 6 6 6 2 Anti-sigma-K factor rskA Zip PF02535.22 CDI87125.1 - 9.7 5.3 8.3 25 3.9 0.0 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter CLN3 PF02487.17 CDI87126.1 - 5.7e-05 22.3 0.0 6.7e-05 22.1 0.0 1.0 1 0 0 1 1 1 1 CLN3 protein Zip PF02535.22 CDI87126.1 - 0.0043 16.3 0.3 0.0049 16.1 0.3 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter SpoIIIAH PF12685.7 CDI87126.1 - 0.0047 16.8 0.1 0.0057 16.5 0.1 1.1 1 0 0 1 1 1 1 SpoIIIAH-like protein Coilin_N PF15862.5 CDI87126.1 - 0.011 15.5 1.0 0.022 14.5 1.0 1.6 1 1 0 1 1 1 0 Coilin N-terminus NESP55 PF06390.12 CDI87126.1 - 0.05 13.2 19.8 0.071 12.7 19.8 1.3 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) SID-1_RNA_chan PF13965.6 CDI87126.1 - 0.078 11.4 0.0 0.087 11.2 0.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Trypan_PARP PF05887.11 CDI87126.1 - 0.087 12.8 15.7 0.12 12.3 15.7 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) V_ATPase_I PF01496.19 CDI87126.1 - 0.091 10.7 0.3 0.1 10.5 0.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TipE PF16972.5 CDI87126.1 - 0.16 11.2 0.0 0.16 11.1 0.0 1.0 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE 7tm_1 PF00001.21 CDI87126.1 - 0.19 11.0 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) HSP90 PF00183.18 CDI87126.1 - 0.25 10.2 4.4 0.32 9.8 4.4 1.2 1 0 0 1 1 1 0 Hsp90 protein FAM176 PF14851.6 CDI87126.1 - 0.38 10.4 8.4 1.1 8.9 8.4 1.7 1 1 0 1 1 1 0 FAM176 family Connexin PF00029.19 CDI87126.1 - 3.6 7.3 9.2 8.4 6.1 9.2 1.6 1 1 0 1 1 1 0 Connexin Sec62 PF03839.16 CDI87126.1 - 3.9 6.9 6.3 5.1 6.5 6.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 MAP17 PF15807.5 CDI87126.1 - 6 7.1 7.3 12 6.2 7.3 1.5 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 MBOAT PF03062.19 CDI87128.1 - 0.19 11.1 5.0 0.26 10.6 5.0 1.1 1 0 0 1 1 1 0 MBOAT, membrane-bound O-acyltransferase family HdeA PF06411.11 CDI87128.1 - 3 8.1 19.3 5.2 7.3 3.5 2.3 2 0 0 2 2 2 0 HdeA/HdeB family RNA_pol_Rpc4 PF05132.14 CDI87128.1 - 6.8 7.1 6.1 2 8.8 2.7 1.8 1 1 1 2 2 2 0 RNA polymerase III RPC4 TAF4 PF05236.14 CDI87129.1 - 0.012 15.4 17.3 0.013 15.3 17.3 1.0 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DUF2052 PF09747.9 CDI87129.1 - 0.077 13.1 17.4 0.088 12.9 17.4 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) MRP-S31 PF15433.6 CDI87129.1 - 0.14 11.8 18.8 0.17 11.5 18.8 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 BAF1_ABF1 PF04684.13 CDI87129.1 - 0.51 9.3 15.0 0.58 9.2 15.0 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CDC45 PF02724.14 CDI87129.1 - 0.52 8.5 12.6 0.59 8.4 12.6 1.0 1 0 0 1 1 1 0 CDC45-like protein GAGA_bind PF06217.12 CDI87129.1 - 0.52 10.5 12.7 0.59 10.4 12.7 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4661 PF15576.6 CDI87129.1 - 0.77 9.6 7.6 0.92 9.4 7.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) DUF4604 PF15377.6 CDI87129.1 - 0.81 10.1 16.2 1 9.8 16.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) FAM176 PF14851.6 CDI87129.1 - 0.81 9.3 8.0 1 9.0 8.0 1.2 1 0 0 1 1 1 0 FAM176 family NST1 PF13945.6 CDI87129.1 - 0.87 9.7 16.8 1.1 9.4 16.8 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator SLC12 PF03522.15 CDI87129.1 - 1.1 8.2 16.2 1.2 8.1 16.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 XAP5 PF04921.14 CDI87129.1 - 1.2 8.9 15.7 1.5 8.6 15.7 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator Vfa1 PF08432.10 CDI87129.1 - 1.2 9.4 14.4 1.5 9.1 14.4 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 MMR1 PF08505.10 CDI87129.1 - 1.9 8.7 17.3 2.1 8.5 17.3 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF853 PF05872.12 CDI87129.1 - 2 6.9 13.6 2.4 6.6 13.6 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) RR_TM4-6 PF06459.12 CDI87129.1 - 2.3 7.9 17.6 2.7 7.7 17.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 CDI87129.1 - 2.5 8.1 13.2 3 7.8 13.2 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2828 PF11443.8 CDI87129.1 - 3.1 5.8 13.4 4 5.4 13.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DDRGK PF09756.9 CDI87129.1 - 3.2 7.3 20.5 4.4 6.8 20.5 1.2 1 0 0 1 1 1 0 DDRGK domain Gti1_Pac2 PF09729.9 CDI87129.1 - 3.9 7.5 9.8 4.9 7.2 9.8 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF2076 PF09849.9 CDI87129.1 - 5 7.1 33.2 6.3 6.8 33.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Macoilin PF09726.9 CDI87129.1 - 5.2 5.5 24.0 6 5.3 24.0 1.0 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI87129.1 - 5.9 6.8 34.3 7.1 6.5 34.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4647 PF15504.6 CDI87129.1 - 6 5.9 16.7 7.1 5.6 16.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Cellulose_synt PF03552.14 CDI87129.1 - 6.4 5.1 4.7 6.9 5.0 4.7 1.0 1 0 0 1 1 1 0 Cellulose synthase hDGE_amylase PF14701.6 CDI87129.1 - 6.8 5.7 10.0 7.5 5.5 10.0 1.0 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Sporozoite_P67 PF05642.11 CDI87129.1 - 6.8 4.6 13.8 7.2 4.6 13.8 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen XRN_M PF17846.1 CDI87129.1 - 6.9 5.5 13.3 7.5 5.4 13.3 1.0 1 0 0 1 1 1 0 Xrn1 helical domain ALMT PF11744.8 CDI87129.1 - 7 5.4 12.6 8 5.2 12.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter MMU163 PF17119.5 CDI87129.1 - 7.8 5.6 8.6 9.4 5.3 8.6 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Menin PF05053.13 CDI87129.1 - 7.8 4.7 13.3 8.7 4.6 13.3 1.0 1 0 0 1 1 1 0 Menin Ndc1_Nup PF09531.10 CDI87129.1 - 8.1 5.0 18.0 9.7 4.7 18.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hid1 PF12722.7 CDI87129.1 - 9.7 4.2 15.9 11 4.0 15.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Glyco_hydro_31 PF01055.26 CDI87130.1 - 8.1e-22 78.0 4.1 8.1e-22 78.0 4.1 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 TFIIA PF03153.13 CDI87130.1 - 0.00011 22.4 81.5 0.0053 16.8 29.6 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit PNISR PF15996.5 CDI87130.1 - 0.00022 21.6 17.5 0.00022 21.6 17.5 2.4 2 1 0 2 2 1 1 Arginine/serine-rich protein PNISR Zip PF02535.22 CDI87130.1 - 0.00039 19.8 13.8 0.00087 18.6 5.1 2.2 2 0 0 2 2 2 2 ZIP Zinc transporter NST1 PF13945.6 CDI87130.1 - 0.015 15.4 20.5 0.015 15.4 20.5 3.0 3 0 0 3 3 2 0 Salt tolerance down-regulator CNDH2_C PF16858.5 CDI87130.1 - 0.046 13.6 36.0 0.12 12.2 20.6 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF4746 PF15928.5 CDI87130.1 - 0.046 13.1 37.3 0.21 11.0 3.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF4179 PF13786.6 CDI87130.1 - 0.087 13.3 0.7 0.087 13.3 0.7 3.5 2 1 1 3 3 2 0 Domain of unknown function (DUF4179) CDC45 PF02724.14 CDI87130.1 - 0.13 10.6 34.1 0.11 10.8 20.4 2.2 2 0 0 2 2 2 0 CDC45-like protein Tim54 PF11711.8 CDI87130.1 - 0.18 10.6 35.9 0.24 10.2 20.2 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 MFAP1 PF06991.11 CDI87130.1 - 0.19 11.6 42.1 0.85 9.4 24.1 2.5 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing CCSAP PF15748.5 CDI87130.1 - 0.3 11.2 56.8 0.11 12.7 16.8 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Connexin PF00029.19 CDI87130.1 - 0.33 10.7 32.2 0.14 11.9 2.7 2.4 2 0 0 2 2 2 0 Connexin TT_ORF1 PF02956.14 CDI87130.1 - 0.76 8.4 19.0 0.54 8.9 9.5 2.1 2 0 0 2 2 2 0 TT viral orf 1 SLC12 PF03522.15 CDI87130.1 - 0.96 8.4 38.4 0.48 9.4 4.7 2.2 2 0 0 2 2 2 0 Solute carrier family 12 SPX PF03105.19 CDI87130.1 - 1.4 8.8 32.1 55 3.5 32.0 2.0 1 1 0 1 1 1 0 SPX domain BAF1_ABF1 PF04684.13 CDI87130.1 - 2.1 7.3 47.8 0.17 10.9 21.5 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Presenilin PF01080.17 CDI87130.1 - 2.8 6.6 49.9 3.4 6.3 12.3 2.2 2 0 0 2 2 2 0 Presenilin Calici_coat PF00915.20 CDI87130.1 - 2.9 6.7 8.3 0.56 9.0 0.1 2.3 2 0 0 2 2 2 0 Calicivirus coat protein DUF4192 PF13830.6 CDI87130.1 - 3 7.8 30.6 1.7 8.7 9.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4192) Porin_4 PF13609.6 CDI87130.1 - 3 7.5 10.4 3.9 7.1 0.2 2.2 2 0 0 2 2 2 0 Gram-negative porin SDA1 PF05285.12 CDI87130.1 - 4.9 6.5 42.2 4.1 6.7 23.6 2.1 2 0 0 2 2 2 0 SDA1 Bud13 PF09736.9 CDI87130.1 - 5.1 7.5 48.1 2 8.8 28.1 2.4 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex DUF4471 PF14740.6 CDI87130.1 - 5.2 6.2 28.0 2 7.6 14.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) Vfa1 PF08432.10 CDI87130.1 - 5.7 7.2 43.7 5.3 7.3 26.2 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 SAGA-Tad1 PF12767.7 CDI87130.1 - 5.9 6.6 30.9 2.6 7.7 6.5 2.2 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit EOS1 PF12326.8 CDI87130.1 - 6.1 6.7 26.6 0.069 13.1 2.0 2.5 2 0 0 2 2 2 0 N-glycosylation protein DUF2052 PF09747.9 CDI87130.1 - 6.1 6.9 46.5 4 7.5 7.3 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Membralin PF09746.9 CDI87130.1 - 8.9 5.2 24.1 6.9 5.6 1.7 2.1 2 0 0 2 2 2 0 Tumour-associated protein MGS PF02142.22 CDI87131.1 - 0.00014 22.0 0.9 0.00025 21.2 0.0 1.9 2 0 0 2 2 1 1 MGS-like domain Rtf2 PF04641.12 CDI87131.1 - 0.00018 21.0 6.9 0.00022 20.7 6.9 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger Eapp_C PF10238.9 CDI87131.1 - 0.0011 19.1 4.0 0.0014 18.7 4.0 1.3 1 0 0 1 1 1 1 E2F-associated phosphoprotein DDHD PF02862.17 CDI87131.1 - 0.0014 18.8 0.7 0.0015 18.7 0.7 1.2 1 0 0 1 1 1 1 DDHD domain Presenilin PF01080.17 CDI87131.1 - 0.0016 17.3 1.7 0.0016 17.3 1.7 1.1 1 0 0 1 1 1 1 Presenilin SpoIIP PF07454.11 CDI87131.1 - 0.0018 17.8 5.4 0.0022 17.5 5.4 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) SR-25 PF10500.9 CDI87131.1 - 0.0025 17.5 29.7 0.0034 17.0 29.7 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Connexin PF00029.19 CDI87131.1 - 0.0034 17.2 6.3 0.0046 16.8 6.3 1.1 1 0 0 1 1 1 1 Connexin Zip PF02535.22 CDI87131.1 - 0.019 14.2 0.8 0.018 14.2 0.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter OATP PF03137.20 CDI87131.1 - 0.039 12.2 4.1 0.05 11.9 4.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family MDM10 PF12519.8 CDI87131.1 - 0.084 11.7 3.3 0.092 11.6 3.3 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Band_3_cyto PF07565.13 CDI87131.1 - 0.09 12.6 2.6 0.1 12.4 2.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4770 PF15994.5 CDI87131.1 - 0.13 12.5 11.0 0.19 12.0 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) BSMAP PF12280.8 CDI87131.1 - 0.13 12.4 3.6 0.18 12.0 3.6 1.1 1 0 0 1 1 1 0 Brain specific membrane anchored protein DUF2370 PF10176.9 CDI87131.1 - 0.16 11.6 0.1 0.2 11.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Otopetrin PF03189.13 CDI87131.1 - 0.33 9.7 1.2 0.4 9.5 1.2 1.1 1 0 0 1 1 1 0 Otopetrin CSG2 PF16965.5 CDI87131.1 - 0.39 9.6 0.7 0.48 9.3 0.7 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator RR_TM4-6 PF06459.12 CDI87131.1 - 0.46 10.3 16.5 0.67 9.7 16.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CENP-N PF05238.13 CDI87131.1 - 0.6 9.3 11.6 0.77 9.0 11.6 1.1 1 0 0 1 1 1 0 Kinetochore protein CHL4 like DUF1168 PF06658.12 CDI87131.1 - 0.8 9.5 31.2 1.4 8.7 31.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Rrn6 PF10214.9 CDI87131.1 - 0.95 7.9 13.2 1.2 7.6 13.2 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor AP3D1 PF06375.11 CDI87131.1 - 0.97 9.7 31.4 2 8.6 31.4 1.5 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Ndc1_Nup PF09531.10 CDI87131.1 - 1.2 7.7 2.9 1.3 7.6 2.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4337 PF14235.6 CDI87131.1 - 1.2 9.2 8.3 1.6 8.8 8.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) GNAT_acetyltr_2 PF13718.6 CDI87131.1 - 1.3 8.3 5.6 1.8 7.9 5.6 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DUF913 PF06025.12 CDI87131.1 - 1.5 7.7 4.2 1.9 7.4 4.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hydin_ADK PF17213.3 CDI87131.1 - 1.6 9.0 5.9 2.6 8.3 5.9 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain RNA_pol_Rpc4 PF05132.14 CDI87131.1 - 2.4 8.6 17.4 4.6 7.7 17.4 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 CLN3 PF02487.17 CDI87131.1 - 2.5 7.0 5.5 3.3 6.7 5.5 1.1 1 0 0 1 1 1 0 CLN3 protein FAM176 PF14851.6 CDI87131.1 - 2.7 7.6 5.5 4.9 6.8 5.5 1.4 1 0 0 1 1 1 0 FAM176 family ORC_WH_C PF18137.1 CDI87131.1 - 2.8 8.0 14.6 5.5 7.1 14.6 1.4 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal EMC3_TMCO1 PF01956.16 CDI87131.1 - 3.7 7.3 9.2 5.1 6.8 9.2 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Vfa1 PF08432.10 CDI87131.1 - 4 7.7 24.2 6.1 7.1 24.2 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CPSF100_C PF13299.6 CDI87131.1 - 4.5 7.4 13.4 7.2 6.8 13.4 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal BRF1 PF07741.13 CDI87131.1 - 6.8 7.1 23.6 2.7 8.4 20.3 1.9 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF3807 PF12720.7 CDI87131.1 - 6.9 6.9 22.6 11 6.2 22.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Peptidase_U57 PF05582.12 CDI87131.1 - 6.9 5.8 10.0 9.5 5.4 10.0 1.1 1 0 0 1 1 1 0 YabG peptidase U57 DUF1764 PF08576.10 CDI87131.1 - 9.3 7.2 22.4 22 6.0 22.4 1.6 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF2076 PF09849.9 CDI87132.1 - 0.0011 19.1 37.8 0.0011 19.1 37.8 2.9 2 1 1 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2076) AAA_11 PF13086.6 CDI87132.1 - 0.21 11.4 61.8 0.16 11.8 21.9 2.2 2 0 0 2 2 2 0 AAA domain RR_TM4-6 PF06459.12 CDI87132.1 - 1.3 8.7 67.0 1 9.1 20.4 2.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Raftlin PF15250.6 CDI87132.1 - 3.3 6.3 59.7 0.31 9.8 30.6 2.2 2 0 0 2 2 2 0 Raftlin Zip PF02535.22 CDI87132.1 - 5.2 6.2 39.8 1.5 8.0 10.7 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter SLC12 PF03522.15 CDI87132.1 - 7.7 5.4 74.8 2.3 7.2 39.2 2.1 2 0 0 2 2 2 0 Solute carrier family 12 BAF1_ABF1 PF04684.13 CDI87132.1 - 8.1 5.4 65.4 3.4 6.6 30.7 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor DDHD PF02862.17 CDI87133.1 - 0.15 12.2 7.8 0.17 12.0 7.8 1.2 1 0 0 1 1 1 0 DDHD domain RNA_polI_A34 PF08208.11 CDI87133.1 - 2.8 8.0 30.3 4.3 7.4 30.3 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RPN2_C PF18004.1 CDI87133.1 - 3.7 7.4 27.0 5.5 6.9 27.0 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Endostatin PF06482.11 CDI87133.1 - 6.4 6.1 12.3 7.3 6.0 12.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SNF2_N PF00176.23 CDI87134.1 - 2.4e-15 56.1 0.0 5.9e-13 48.3 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain zf-C4_Topoisom PF01396.19 CDI87134.1 - 4.3e-08 32.8 3.5 1.2e-07 31.4 3.5 1.7 1 0 0 1 1 1 1 Topoisomerase DNA binding C4 zinc finger HNH PF01844.23 CDI87134.1 - 0.00065 19.8 0.1 0.00065 19.8 0.1 2.2 2 0 0 2 2 2 1 HNH endonuclease ResIII PF04851.15 CDI87134.1 - 0.0026 17.8 0.0 0.0083 16.1 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDI87134.1 - 0.0031 17.8 0.1 0.01 16.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDI87134.1 - 0.011 15.5 0.0 0.03 14.1 0.0 1.7 1 0 0 1 1 1 0 DEAD/DEAH box helicase Cyclin PF08613.11 CDI87136.1 - 2.1e-29 103.0 0.0 5.8e-29 101.5 0.0 1.8 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 CDI87136.1 - 9.3e-07 28.6 0.0 9.3e-07 28.6 0.0 3.7 3 1 1 4 4 4 1 Cyclin, N-terminal domain dCMP_cyt_deam_2 PF08211.12 CDI87136.1 - 0.2 11.8 0.1 0.2 11.8 0.1 2.3 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region CH_2 PF06294.11 CDI87138.1 - 7.3e-15 54.9 0.3 1.1e-06 28.7 0.0 2.8 2 0 0 2 2 2 2 CH-like domain in sperm protein TFB6 PF17110.5 CDI87138.1 - 2.4 7.9 6.3 7.9 6.2 6.3 1.9 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Roughex PF06020.11 CDI87138.1 - 4.4 6.3 14.6 14 4.7 14.6 2.0 1 0 0 1 1 1 0 Drosophila roughex protein DUF572 PF04502.13 CDI87139.1 - 5.6 6.5 32.9 6.6 6.3 32.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Pkinase PF00069.25 CDI87140.1 - 1.6e-08 34.2 0.0 1.6e-08 34.2 0.0 6.4 4 3 2 6 6 6 2 Protein kinase domain DUF2722 PF10846.8 CDI87140.1 - 0.0034 16.4 12.7 0.0034 16.4 12.7 13.0 8 3 3 12 12 12 3 Protein of unknown function (DUF2722) RskA PF10099.9 CDI87141.1 - 2e-05 24.9 15.9 2e-05 24.9 15.9 3.2 1 1 2 3 3 3 1 Anti-sigma-K factor rskA RXLR PF16810.5 CDI87141.1 - 0.003 18.0 7.6 0.003 18.0 7.6 3.4 3 1 0 3 3 3 1 RXLR phytopathogen effector protein, Avirulence activity DUF4179 PF13786.6 CDI87141.1 - 5.3 7.6 24.9 4.4 7.8 1.1 4.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4179) UPF0564 PF10595.9 CDI87144.1 - 0.0059 15.7 17.7 0.0076 15.3 17.7 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0564 TFIIA PF03153.13 CDI87144.1 - 0.014 15.5 39.1 0.022 14.7 39.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hamartin PF04388.12 CDI87144.1 - 0.056 12.1 20.9 0.07 11.8 20.9 1.0 1 0 0 1 1 1 0 Hamartin protein SR-25 PF10500.9 CDI87144.1 - 0.12 12.0 36.2 0.014 15.0 10.1 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein PPP4R2 PF09184.11 CDI87144.1 - 0.13 11.8 14.2 0.17 11.4 14.2 1.1 1 0 0 1 1 1 0 PPP4R2 eIF-3_zeta PF05091.12 CDI87144.1 - 0.17 10.8 15.0 0.2 10.6 15.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4407 PF14362.6 CDI87144.1 - 0.45 9.8 13.1 0.57 9.5 13.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Utp14 PF04615.13 CDI87144.1 - 0.84 8.1 20.1 1 7.8 20.1 1.0 1 0 0 1 1 1 0 Utp14 protein V_ATPase_I PF01496.19 CDI87144.1 - 1.1 7.1 13.4 1.5 6.6 13.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1764 PF08576.10 CDI87144.1 - 1.8 9.5 12.8 1.2 10.1 8.9 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Transket_pyr PF02779.24 CDI87145.1 - 1.7e-41 141.9 0.0 2.8e-41 141.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDI87145.1 - 1.2e-37 128.5 0.2 2e-37 127.8 0.2 1.3 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 CDI87145.1 - 0.05 13.9 0.0 0.083 13.2 0.0 1.3 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II Thiamine_BP PF01910.17 CDI87145.1 - 0.075 13.0 0.2 0.13 12.2 0.2 1.3 1 0 0 1 1 1 0 Thiamine-binding protein RskA PF10099.9 CDI87148.1 - 0.012 15.9 0.1 0.012 15.9 0.1 10.4 6 3 2 8 8 8 0 Anti-sigma-K factor rskA Lact-deh-memb PF09330.11 CDI87148.1 - 0.017 14.5 0.1 0.049 13.0 0.0 1.7 1 1 0 1 1 1 0 D-lactate dehydrogenase, membrane binding PAT1 PF09770.9 CDI87149.1 - 2.5 6.3 17.5 2.6 6.2 17.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2722 PF10846.8 CDI87151.1 - 0.00037 19.6 12.6 0.00037 19.6 12.6 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI87151.1 - 0.0013 19.1 26.8 0.0013 19.1 26.8 2.3 1 1 1 2 2 1 1 Anti-sigma-K factor rskA nec1 PF10379.9 CDI87151.1 - 0.013 15.0 0.3 0.016 14.7 0.3 1.1 1 0 0 1 1 1 0 Virulence protein nec1 DUF3381 PF11861.8 CDI87151.1 - 0.051 13.4 21.7 0.57 10.0 6.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) DUF4834 PF16118.5 CDI87151.1 - 0.093 13.7 27.3 1.1 10.3 9.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Connexin PF00029.19 CDI87151.1 - 0.12 12.1 13.6 0.66 9.7 4.2 2.1 2 0 0 2 2 2 0 Connexin CAF1 PF04857.20 CDI87151.1 - 0.19 10.9 10.2 0.27 10.4 10.2 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease TCP PF03634.13 CDI87151.1 - 0.26 11.8 21.7 1.6 9.3 7.2 2.2 2 0 0 2 2 2 0 TCP family transcription factor SpoIIP PF07454.11 CDI87151.1 - 0.27 10.7 22.0 0.22 11.0 2.4 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) PH_4 PF15404.6 CDI87151.1 - 0.46 10.3 12.1 0.48 10.2 2.1 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain TFB6 PF17110.5 CDI87151.1 - 0.58 9.9 14.4 2.7 7.7 6.0 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH eIF-3_zeta PF05091.12 CDI87151.1 - 1.1 8.2 28.6 0.4 9.6 9.7 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) UPF0524 PF15823.5 CDI87151.1 - 1.1 8.6 13.3 0.7 9.2 2.4 2.1 2 0 0 2 2 2 0 UPF0524 of C3orf70 RAB3GAP2_N PF14655.6 CDI87151.1 - 1.4 8.1 19.1 0.8 8.9 5.8 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Pinin_SDK_memA PF04696.13 CDI87151.1 - 1.8 8.6 39.9 0.71 9.9 13.3 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region EPL1 PF10513.9 CDI87151.1 - 2 8.8 26.4 0.2 12.1 3.2 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF5385 PF17359.2 CDI87151.1 - 2.8 7.5 23.7 0.21 11.1 2.5 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5385) FAM176 PF14851.6 CDI87151.1 - 2.8 7.6 15.1 2.3 7.9 1.1 2.2 2 0 0 2 2 2 0 FAM176 family Neuraminidase PF18413.1 CDI87151.1 - 5.3 6.7 13.5 1.8 8.2 2.7 2.3 2 0 0 2 2 2 0 Neuraminidase-like domain UPF0239 PF06783.11 CDI87151.1 - 5.4 7.3 15.1 1.4 9.2 4.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) Coilin_N PF15862.5 CDI87151.1 - 6.7 6.5 30.7 0.21 11.4 10.7 2.2 2 0 0 2 2 2 0 Coilin N-terminus TRM13 PF05206.14 CDI87151.1 - 9.4 5.7 16.0 6.1 6.3 2.6 2.1 2 0 0 2 2 2 0 Methyltransferase TRM13 Ribosomal_L24e PF01246.20 CDI87152.1 - 1.2e-23 83.0 0.7 1.2e-23 83.0 0.7 2.2 3 0 0 3 3 3 1 Ribosomal protein L24e PI31_Prot_C PF08577.11 CDI87152.1 - 0.082 14.1 0.5 21 6.3 0.1 2.3 1 1 1 2 2 2 0 PI31 proteasome regulator DUF775 PF05603.12 CDI87152.1 - 0.12 11.9 1.8 0.17 11.4 1.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF775) RskA PF10099.9 CDI87153.1 - 0.0017 18.7 4.8 0.0017 18.7 4.8 4.4 2 1 2 4 4 3 1 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI87153.1 - 0.0025 16.8 14.7 0.0025 16.8 14.7 4.1 2 1 2 4 4 2 1 Protein of unknown function (DUF2722) Ndc1_Nup PF09531.10 CDI87153.1 - 0.033 12.9 30.5 0.26 9.9 6.2 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup AF-4 PF05110.13 CDI87153.1 - 0.075 11.1 33.9 0.38 8.8 11.6 2.2 2 0 0 2 2 2 0 AF-4 proto-oncoprotein DUF3040 PF11239.8 CDI87153.1 - 0.094 13.0 0.1 0.094 13.0 0.1 4.4 4 1 0 4 4 4 0 Protein of unknown function (DUF3040) Peptidase_S64 PF08192.11 CDI87153.1 - 0.4 9.1 26.1 1.1 7.7 7.5 2.0 2 0 0 2 2 2 0 Peptidase family S64 Utp14 PF04615.13 CDI87153.1 - 0.68 8.4 29.7 0.33 9.5 4.8 2.0 2 0 0 2 2 2 0 Utp14 protein Sin_N PF04801.13 CDI87153.1 - 1.3 8.2 37.7 1.9 7.6 6.4 2.3 2 0 0 2 2 2 0 Sin-like protein conserved region Lin-8 PF03353.15 CDI87153.1 - 2.7 7.4 38.7 0.3 10.6 8.2 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist SPX PF03105.19 CDI87153.1 - 3.1 7.6 32.5 0.63 9.9 5.1 2.1 2 0 0 2 2 2 0 SPX domain SLC12 PF03522.15 CDI87153.1 - 3.3 6.6 27.2 2.7 6.9 4.4 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Plasmodium_Vir PF05795.11 CDI87153.1 - 3.3 7.0 15.5 4.6 6.6 3.6 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Apt1 PF10351.9 CDI87153.1 - 3.7 6.3 22.2 2 7.2 7.4 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain eIF-3_zeta PF05091.12 CDI87154.1 - 0.043 12.8 26.6 0.05 12.6 26.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI87154.1 - 0.14 10.9 23.7 0.15 10.8 23.7 1.2 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 CDI87154.1 - 0.18 10.6 16.5 0.19 10.5 16.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2126 PF09899.9 CDI87154.1 - 0.19 9.8 16.8 0.2 9.7 16.8 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CDC45 PF02724.14 CDI87154.1 - 0.19 10.0 15.9 0.18 10.1 15.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Gti1_Pac2 PF09729.9 CDI87154.1 - 0.21 11.7 15.0 0.23 11.5 15.0 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family SpoIIP PF07454.11 CDI87154.1 - 0.28 10.6 19.2 0.36 10.3 19.2 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 CDI87154.1 - 0.34 10.6 14.3 0.43 10.3 14.3 1.2 1 0 0 1 1 1 0 Connexin SLC12 PF03522.15 CDI87154.1 - 0.39 9.7 19.9 0.4 9.6 19.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4746 PF15928.5 CDI87154.1 - 0.39 10.1 16.5 0.46 9.9 16.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CSRNP_N PF16019.5 CDI87154.1 - 0.41 10.5 17.8 0.51 10.2 17.8 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus PPL5 PF18168.1 CDI87154.1 - 0.43 9.8 13.7 0.46 9.7 13.7 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF908 PF06012.12 CDI87154.1 - 0.46 9.8 16.3 0.54 9.6 16.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) FAM60A PF15396.6 CDI87154.1 - 0.47 10.4 14.5 0.47 10.4 14.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Band_3_cyto PF07565.13 CDI87154.1 - 0.5 10.1 18.0 0.57 9.9 18.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DDRGK PF09756.9 CDI87154.1 - 0.57 9.8 27.4 0.76 9.3 27.4 1.2 1 0 0 1 1 1 0 DDRGK domain Lin-8 PF03353.15 CDI87154.1 - 0.64 9.5 23.8 0.63 9.5 23.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF3402 PF11882.8 CDI87154.1 - 0.64 9.1 15.7 0.66 9.0 15.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) CSG2 PF16965.5 CDI87154.1 - 0.77 8.6 8.9 0.87 8.5 8.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DAG_kinase_N PF14513.6 CDI87154.1 - 0.9 9.7 17.3 1.1 9.5 17.3 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Velvet PF11754.8 CDI87154.1 - 1 9.2 18.5 1.1 9.1 18.5 1.3 1 0 0 1 1 1 0 Velvet factor ALMT PF11744.8 CDI87154.1 - 1.2 7.9 17.8 1.3 7.8 17.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Peptidase_S64 PF08192.11 CDI87154.1 - 1.2 7.5 16.5 1.3 7.5 16.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 Tim54 PF11711.8 CDI87154.1 - 1.2 7.8 18.0 1.4 7.6 18.0 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Endostatin PF06482.11 CDI87154.1 - 1.4 8.3 19.6 1.5 8.2 19.6 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF913 PF06025.12 CDI87154.1 - 1.5 7.7 14.0 1.7 7.6 14.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3807 PF12720.7 CDI87154.1 - 1.7 8.9 30.3 2.2 8.5 30.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF2828 PF11443.8 CDI87154.1 - 1.8 6.5 21.1 1.9 6.5 21.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) GAGA_bind PF06217.12 CDI87154.1 - 1.9 8.7 18.7 1.9 8.7 18.7 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family LptF_LptG PF03739.14 CDI87154.1 - 2.1 7.1 7.3 2.4 6.9 7.3 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Neur_chan_memb PF02932.16 CDI87154.1 - 2.1 8.3 20.5 2.5 8.1 20.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Draxin PF15550.6 CDI87154.1 - 2.3 8.0 19.9 2.8 7.7 19.9 1.0 1 0 0 1 1 1 0 Draxin GPCR_chapero_1 PF11904.8 CDI87154.1 - 2.5 7.5 11.9 2.6 7.4 11.9 1.2 1 0 0 1 1 1 0 GPCR-chaperone DUF2370 PF10176.9 CDI87154.1 - 2.5 7.7 10.8 2.8 7.5 10.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF4638 PF15472.6 CDI87154.1 - 2.7 7.7 19.2 3 7.5 19.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Sin_N PF04801.13 CDI87154.1 - 2.7 7.1 30.8 3.3 6.8 30.8 1.3 1 0 0 1 1 1 0 Sin-like protein conserved region Pkinase_fungal PF17667.1 CDI87154.1 - 2.8 6.6 11.3 2.6 6.7 11.3 1.1 1 0 0 1 1 1 0 Fungal protein kinase MDM10 PF12519.8 CDI87154.1 - 3 6.6 17.2 3.2 6.5 17.2 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CLN3 PF02487.17 CDI87154.1 - 3.1 6.7 16.5 3.5 6.6 16.5 1.2 1 0 0 1 1 1 0 CLN3 protein MFMR_assoc PF16596.5 CDI87154.1 - 3.6 8.1 14.8 2.1 8.8 13.1 1.4 1 1 0 1 1 1 0 Disordered region downstream of MFMR PCNP PF15473.6 CDI87154.1 - 3.9 8.2 16.3 5.7 7.7 16.3 1.3 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family Membralin PF09746.9 CDI87154.1 - 4.1 6.4 13.5 4.4 6.3 13.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein LAP1C PF05609.12 CDI87154.1 - 4.8 6.2 25.2 5.8 5.9 25.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) FemAB PF02388.16 CDI87154.1 - 4.9 5.9 19.6 4.8 5.9 19.6 1.1 1 0 0 1 1 1 0 FemAB family DUF3527 PF12043.8 CDI87154.1 - 4.9 6.6 16.6 6 6.3 16.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) AF-4 PF05110.13 CDI87154.1 - 5.2 5.0 27.9 5.2 5.0 27.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein MAJIN PF15077.6 CDI87154.1 - 5.4 6.7 14.4 5.8 6.6 14.4 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Zip PF02535.22 CDI87154.1 - 5.5 6.1 12.8 6.4 5.9 12.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter BAF1_ABF1 PF04684.13 CDI87154.1 - 5.5 5.9 26.9 6.6 5.7 26.9 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Otopetrin PF03189.13 CDI87154.1 - 5.8 5.6 12.5 6.7 5.4 12.5 1.2 1 0 0 1 1 1 0 Otopetrin Peptidase_U57 PF05582.12 CDI87154.1 - 5.8 6.1 16.3 8 5.6 16.3 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Pannexin_like PF12534.8 CDI87154.1 - 6 5.8 13.9 6.7 5.7 13.9 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 SID-1_RNA_chan PF13965.6 CDI87154.1 - 6 5.1 12.1 6.9 4.9 12.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 HCO3_cotransp PF00955.21 CDI87154.1 - 6.2 5.5 9.1 7 5.4 9.1 1.1 1 0 0 1 1 1 0 HCO3- transporter family Afi1 PF07792.12 CDI87154.1 - 6.2 7.3 20.1 8 6.9 20.1 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking SOG2 PF10428.9 CDI87154.1 - 6.6 5.8 21.4 7.6 5.6 21.4 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Hid1 PF12722.7 CDI87154.1 - 6.9 4.7 21.9 7.1 4.6 21.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4045 PF13254.6 CDI87154.1 - 7.9 6.0 24.0 9.1 5.8 24.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SAPS PF04499.15 CDI87154.1 - 8.1 5.1 16.2 8.2 5.1 16.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Cellulose_synt PF03552.14 CDI87154.1 - 8.3 4.8 7.8 8.1 4.8 7.8 1.0 1 0 0 1 1 1 0 Cellulose synthase Exonuc_VII_L PF02601.15 CDI87155.1 - 0.018 14.6 27.0 0.026 14.1 27.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit SMYLE_N PF18615.1 CDI87155.1 - 0.018 14.6 14.4 0.021 14.4 14.4 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Smg8_Smg9 PF10220.9 CDI87155.1 - 0.021 13.2 17.1 0.022 13.1 17.1 1.1 1 0 0 1 1 1 0 Smg8_Smg9 V_ATPase_I PF01496.19 CDI87155.1 - 0.028 12.4 15.9 0.032 12.2 15.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 CDI87155.1 - 0.044 12.6 23.2 0.055 12.2 23.2 1.2 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 CDI87155.1 - 0.068 12.1 8.8 0.073 12.0 8.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Esterase PF00756.20 CDI87155.1 - 0.092 12.4 11.6 0.12 12.0 11.6 1.2 1 0 0 1 1 1 0 Putative esterase Neur_chan_memb PF02932.16 CDI87155.1 - 0.18 11.9 19.6 0.25 11.3 19.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 CDI87155.1 - 0.21 9.7 18.2 0.21 9.7 18.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GET2 PF08690.10 CDI87155.1 - 0.27 10.9 20.2 0.36 10.5 20.2 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 MMR1 PF08505.10 CDI87155.1 - 0.28 11.5 23.6 0.39 11.0 23.6 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Rgp1 PF08737.10 CDI87155.1 - 0.44 9.7 18.2 0.49 9.5 18.2 1.1 1 0 0 1 1 1 0 Rgp1 Hamartin PF04388.12 CDI87155.1 - 0.51 8.9 20.4 0.59 8.7 20.4 1.1 1 0 0 1 1 1 0 Hamartin protein CDK5_activator PF03261.15 CDI87155.1 - 0.63 9.5 15.7 0.65 9.5 15.7 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Het-C PF07217.11 CDI87155.1 - 0.7 8.3 15.0 0.88 8.0 15.0 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C SLC12 PF03522.15 CDI87155.1 - 1.3 8.0 21.5 1.5 7.8 21.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI87155.1 - 1.3 7.2 40.7 1.5 7.0 40.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3295 PF11702.8 CDI87155.1 - 2 7.7 33.4 0.24 10.7 28.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3295) Lin-8 PF03353.15 CDI87155.1 - 2.2 7.8 24.4 2.8 7.4 24.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MDM10 PF12519.8 CDI87155.1 - 2.2 7.1 15.0 2.8 6.7 14.9 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Membralin PF09746.9 CDI87155.1 - 2.5 7.1 11.2 3.1 6.7 11.2 1.2 1 0 0 1 1 1 0 Tumour-associated protein ALMT PF11744.8 CDI87155.1 - 3.4 6.4 15.0 4 6.1 15.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter RIFIN PF02009.16 CDI87155.1 - 3.5 7.4 18.9 4.6 7.1 18.9 1.2 1 0 0 1 1 1 0 Rifin GREB1 PF15782.5 CDI87155.1 - 3.9 4.5 23.5 3.9 4.5 23.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SKA1 PF07160.12 CDI87155.1 - 4.6 7.0 23.3 8.2 6.2 23.3 1.4 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Med19 PF10278.9 CDI87155.1 - 4.8 7.1 14.4 8.5 6.3 14.4 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Ndc1_Nup PF09531.10 CDI87155.1 - 7.2 5.2 22.2 7.9 5.0 22.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Paramyxo_ncap PF00973.19 CDI87155.1 - 8.5 5.2 15.8 9.6 5.0 15.8 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein VIR_N PF15912.5 CDI87155.1 - 9.5 5.7 16.0 13 5.3 16.0 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DUF755 PF05501.11 CDI87156.1 - 0.0068 16.7 27.5 0.0068 16.7 27.5 5.6 4 2 1 5 5 5 1 Domain of unknown function (DUF755) Anticodon_1 PF08264.13 CDI87157.1 - 2.8e-09 37.1 0.1 9.2e-08 32.2 0.0 2.3 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA Macoilin PF09726.9 CDI87157.1 - 0.0015 17.2 33.0 0.002 16.8 33.0 1.1 1 0 0 1 1 1 1 Macoilin family PAT1 PF09770.9 CDI87157.1 - 0.0021 16.4 21.7 0.0023 16.3 21.7 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 CDI87157.1 - 0.008 16.2 44.9 0.013 15.5 44.9 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Ureide_permease PF07168.11 CDI87157.1 - 0.0087 14.8 1.1 0.0087 14.8 1.1 1.7 2 0 0 2 2 2 1 Ureide permease Striatin PF08232.12 CDI87157.1 - 0.01 16.4 19.1 0.01 16.4 19.1 2.1 2 0 0 2 2 2 0 Striatin family DUF4746 PF15928.5 CDI87157.1 - 0.013 15.0 7.0 0.02 14.3 7.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PTPRCAP PF15713.5 CDI87157.1 - 0.015 15.6 11.6 0.015 15.6 11.6 2.0 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated SpoIIP PF07454.11 CDI87157.1 - 0.024 14.1 14.9 0.026 14.0 10.7 2.0 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) ABC2_membrane_2 PF12679.7 CDI87157.1 - 0.04 13.2 0.7 0.053 12.8 0.7 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF1682 PF07946.14 CDI87157.1 - 0.043 13.0 6.3 0.051 12.8 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) EMC3_TMCO1 PF01956.16 CDI87157.1 - 0.064 13.0 8.9 0.13 12.0 8.9 1.6 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Borrelia_P83 PF05262.11 CDI87157.1 - 0.11 11.0 12.7 0.13 10.8 12.7 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein FliP PF00813.20 CDI87157.1 - 0.13 12.1 4.6 0.19 11.6 4.6 1.2 1 0 0 1 1 1 0 FliP family RP-C_C PF11800.8 CDI87157.1 - 0.19 11.8 19.1 0.032 14.3 11.1 2.0 2 0 0 2 2 2 0 Replication protein C C-terminal region NPR3 PF03666.13 CDI87157.1 - 0.2 10.4 20.7 0.084 11.7 9.2 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Pex14_N PF04695.13 CDI87157.1 - 0.29 11.8 31.4 0.066 13.9 19.6 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2370 PF10176.9 CDI87157.1 - 0.31 10.7 11.0 0.057 13.1 5.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) eIF-3_zeta PF05091.12 CDI87157.1 - 0.38 9.7 19.5 0.58 9.1 19.5 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2126 PF09899.9 CDI87157.1 - 0.41 8.6 7.8 0.53 8.3 7.8 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) LMBR1 PF04791.16 CDI87157.1 - 0.42 9.5 8.5 0.5 9.2 8.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein NAM-associated PF14303.6 CDI87157.1 - 0.42 11.3 22.7 2.4 8.8 22.7 2.0 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain Peptidase_S49_N PF08496.10 CDI87157.1 - 0.55 10.3 16.6 0.86 9.7 16.6 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal 5_nucleotid PF05761.14 CDI87157.1 - 0.58 9.0 10.6 0.76 8.6 10.6 1.2 1 0 0 1 1 1 0 5' nucleotidase family NicO PF03824.16 CDI87157.1 - 0.62 9.4 3.2 0.93 8.8 3.2 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein FAM60A PF15396.6 CDI87157.1 - 0.65 10.0 19.7 0.56 10.2 10.3 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Ctr PF04145.15 CDI87157.1 - 0.68 10.5 17.9 1.1 9.8 10.5 2.2 2 0 0 2 2 2 0 Ctr copper transporter family Tim54 PF11711.8 CDI87157.1 - 0.68 8.7 12.8 0.022 13.6 5.5 1.8 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Gti1_Pac2 PF09729.9 CDI87157.1 - 0.72 9.9 23.4 0.56 10.3 1.3 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family Phage_GPO PF05929.11 CDI87157.1 - 0.76 9.4 15.4 1.1 8.9 15.4 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase CCDC53 PF10152.9 CDI87157.1 - 0.97 9.8 19.5 0.24 11.8 12.6 2.1 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Pinin_SDK_memA PF04696.13 CDI87157.1 - 1 9.4 33.8 1.6 8.8 33.8 1.2 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region GEMIN8 PF15348.6 CDI87157.1 - 1.3 9.3 28.5 1.7 8.9 3.0 2.1 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 Connexin PF00029.19 CDI87157.1 - 1.3 8.7 15.5 0.18 11.6 10.7 1.8 2 0 0 2 2 2 0 Connexin CobT PF06213.12 CDI87157.1 - 1.4 8.2 31.0 0.06 12.7 21.8 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT FapA PF03961.13 CDI87157.1 - 1.5 7.4 10.7 1.9 7.0 10.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A UPF0242 PF06785.11 CDI87157.1 - 1.9 8.5 33.1 3.2 7.8 33.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Peptidase_U57 PF05582.12 CDI87157.1 - 1.9 7.7 12.7 0.7 9.1 9.3 1.8 2 0 0 2 2 2 0 YabG peptidase U57 PepSY_TM PF03929.16 CDI87157.1 - 2 8.0 6.8 2.9 7.5 6.8 1.2 1 0 0 1 1 1 0 PepSY-associated TM region CPSF100_C PF13299.6 CDI87157.1 - 2.1 8.5 15.5 1.2 9.4 9.9 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Zip PF02535.22 CDI87157.1 - 3 7.0 16.8 0.31 10.2 7.6 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4776 PF16003.5 CDI87157.1 - 3.2 6.6 22.7 4.4 6.2 22.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) CLN3 PF02487.17 CDI87157.1 - 3.5 6.6 15.6 0.44 9.6 9.3 2.0 2 0 0 2 2 2 0 CLN3 protein DUF913 PF06025.12 CDI87157.1 - 4.3 6.2 22.6 1 8.2 2.0 2.1 1 1 1 2 2 2 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 CDI87157.1 - 4.3 7.1 19.9 0.26 11.1 13.7 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Hamartin PF04388.12 CDI87157.1 - 4.6 5.8 28.1 7 5.2 28.1 1.2 1 0 0 1 1 1 0 Hamartin protein Membralin PF09746.9 CDI87157.1 - 5.1 6.0 14.6 0.52 9.3 8.2 1.9 2 0 0 2 2 2 0 Tumour-associated protein DUF4192 PF13830.6 CDI87157.1 - 5.5 7.0 5.7 5.1 7.1 3.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4192) EBP50_C PF09007.11 CDI87157.1 - 6.5 7.8 25.6 12 6.9 10.0 2.3 2 0 0 2 2 2 0 EBP50, C-terminal DUF2052 PF09747.9 CDI87157.1 - 6.9 6.7 22.1 0.72 9.9 16.8 1.8 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) O-antigen_lig PF13425.6 CDI87157.1 - 8.4 5.1 7.0 13 4.5 7.0 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein BORG_CEP PF14957.6 CDI87157.1 - 8.5 7.6 22.2 0.39 11.9 6.7 2.2 2 0 0 2 2 2 0 Cdc42 effector tRNA-synt_1 PF00133.22 CDI87158.1 - 2.4e-05 22.8 0.0 0.00079 17.8 0.0 3.6 4 0 0 4 4 4 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CDI87158.1 - 4.6e-05 22.3 0.4 4.6e-05 22.3 0.4 3.0 3 0 0 3 3 3 1 tRNA synthetases class I (M) RskA PF10099.9 CDI87158.1 - 0.00077 19.8 13.1 0.00077 19.8 13.1 7.0 4 2 0 4 4 4 2 Anti-sigma-K factor rskA DUF737 PF05300.11 CDI87158.1 - 0.0019 18.6 5.1 0.0019 18.6 5.1 5.3 2 1 1 3 3 3 1 Protein of unknown function (DUF737) Fringe PF02434.16 CDI87160.1 - 1.3e-15 57.5 5.0 1.1e-09 38.1 0.0 3.9 3 1 1 4 4 4 3 Fringe-like SR-25 PF10500.9 CDI87160.1 - 0.0093 15.6 9.3 0.018 14.7 9.3 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 CDI87160.1 - 2 6.4 8.5 2.8 5.9 8.5 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Secretin_N_2 PF07655.13 CDI87160.1 - 2.4 8.8 12.5 2.1 9.0 5.9 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain IMUP PF15761.5 CDI87160.1 - 3 8.6 9.7 9.1 7.0 9.7 1.8 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF755 PF05501.11 CDI87160.1 - 10 6.4 17.9 24 5.2 17.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF755) SARAF PF06682.12 CDI87161.1 - 0.0034 17.1 12.1 0.0034 17.1 12.1 6.7 3 2 2 6 6 6 1 SOCE-associated regulatory factor of calcium homoeostasis LptF_LptG PF03739.14 CDI87161.1 - 0.027 13.3 1.5 2.7 6.8 0.4 2.5 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG PepSY_TM PF03929.16 CDI87161.1 - 0.11 12.2 0.1 0.11 12.2 0.1 7.1 4 3 0 4 4 4 0 PepSY-associated TM region DUF2433 PF10360.9 CDI87161.1 - 1.2 9.2 4.6 2.8 8.0 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2433) MCM PF00493.23 CDI87163.1 - 8.2e-90 299.8 0.2 1.4e-89 299.0 0.2 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 CDI87163.1 - 3.9e-26 91.3 2.5 7.5e-26 90.4 2.5 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 CDI87163.1 - 5.1e-26 91.0 0.0 1.3e-25 89.7 0.0 1.7 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 CDI87163.1 - 1.1e-06 28.2 0.1 6e-06 25.8 0.0 2.0 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CDI87163.1 - 0.0044 16.9 0.0 0.011 15.5 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_7 PF17867.1 CDI87163.1 - 0.0084 16.3 0.7 0.021 15.0 0.7 1.6 1 0 0 1 1 1 1 Midasin AAA lid domain AAA_5 PF07728.14 CDI87163.1 - 0.014 15.4 0.0 0.035 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) BAG PF02179.16 CDI87163.1 - 2.7 8.5 5.5 0.89 10.0 0.2 2.8 3 0 0 3 3 3 0 BAG domain PT PF04886.12 CDI87165.1 - 0.0001 21.7 20.6 0.0001 21.7 20.6 4.6 3 2 1 4 4 4 2 PT repeat RVP_2 PF08284.11 CDI87166.1 - 4.5e-09 36.2 0.0 8.1e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CDI87166.1 - 3e-06 27.8 0.0 1.1e-05 25.9 0.0 2.0 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI87166.1 - 8.3e-05 23.1 0.0 0.00029 21.3 0.0 2.1 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 CDI87166.1 - 0.018 14.9 0.0 0.033 14.0 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.20 CDI87166.1 - 0.041 14.2 0.0 0.097 13.0 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease TPX2 PF06886.11 CDI87166.1 - 0.11 12.7 1.6 9.3 6.6 0.1 2.5 2 0 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) RT_RNaseH_2 PF17919.1 CDI87167.1 - 1.8e-28 98.5 0.0 3.1e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI87167.1 - 6.5e-28 97.1 0.0 1.1e-27 96.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDI87167.1 - 2.7e-18 66.3 0.0 4.7e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CDI87168.1 - 4.2e-08 33.4 0.1 7e-07 29.5 0.1 2.4 1 1 0 1 1 1 1 Integrase core domain SecM PF06558.12 CDI87168.1 - 0.014 15.5 0.1 0.026 14.6 0.1 1.4 1 0 0 1 1 1 0 Secretion monitor precursor protein (SecM) Ribosomal_L14 PF00238.19 CDI87169.1 - 0.0017 18.5 4.2 0.0017 18.5 4.2 2.2 2 1 0 2 2 2 1 Ribosomal protein L14p/L23e DUF775 PF05603.12 CDI87169.1 - 0.015 14.8 22.5 0.015 14.8 22.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF775) Chorein_N PF12624.7 CDI87169.1 - 0.049 13.7 1.0 0.049 13.7 1.0 3.1 3 0 0 3 3 3 0 N-terminal region of Chorein or VPS13 Cloacin PF03515.14 CDI87169.1 - 0.11 12.1 0.4 0.11 12.1 0.4 2.9 3 0 0 3 3 1 0 Colicin-like bacteriocin tRNase domain DUF2052 PF09747.9 CDI87169.1 - 0.13 12.4 21.1 0.19 11.9 21.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) BAF1_ABF1 PF04684.13 CDI87169.1 - 0.14 11.2 17.9 0.15 11.1 17.9 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Pannexin_like PF12534.8 CDI87169.1 - 0.26 10.3 16.3 0.017 14.3 7.7 2.0 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 Auxin_canalis PF05703.11 CDI87169.1 - 0.38 10.6 13.6 0.45 10.4 13.6 1.0 1 0 0 1 1 1 0 Auxin canalisation SLC12 PF03522.15 CDI87169.1 - 0.39 9.7 25.4 0.51 9.3 25.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Lin-8 PF03353.15 CDI87169.1 - 1.1 8.7 29.5 1.4 8.4 29.5 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CobT PF06213.12 CDI87169.1 - 1.2 8.5 36.7 0.27 10.6 22.6 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT PAT1 PF09770.9 CDI87169.1 - 1.4 7.1 47.6 1.7 6.8 47.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Endostatin PF06482.11 CDI87169.1 - 2 7.8 23.3 3 7.2 23.3 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CCSAP PF15748.5 CDI87169.1 - 2.4 8.3 31.0 3.4 7.8 31.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated HemX PF04375.14 CDI87169.1 - 2.6 7.2 46.5 0.15 11.3 31.7 2.0 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Hid1 PF12722.7 CDI87169.1 - 2.7 6.0 24.3 3.3 5.7 24.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GPCR_chapero_1 PF11904.8 CDI87169.1 - 4.7 6.6 15.6 7 6.0 15.6 1.3 1 0 0 1 1 1 0 GPCR-chaperone DUF4551 PF15087.6 CDI87169.1 - 7.6 5.2 22.3 9.3 5.0 22.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Ribosomal_60s PF00428.19 CDI87170.1 - 0.53 10.9 28.5 1.9 9.1 7.2 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein Chorion_S16 PF05836.12 CDI87170.1 - 2.7 8.2 15.2 2 8.7 4.6 2.2 2 0 0 2 2 2 0 Chorion protein S16 Glyco_hydro_9 PF00759.19 CDI87172.1 - 2.6 7.4 30.1 3.8 6.8 30.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 DUF2339 PF10101.9 CDI87173.1 - 0.00019 20.2 3.0 0.00026 19.7 3.0 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2339) COX6C PF02937.15 CDI87173.1 - 0.73 10.0 2.5 18 5.6 0.1 2.6 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc Dapper PF15268.6 CDI87173.1 - 2.3 7.0 48.7 3.5 6.4 48.7 1.3 1 0 0 1 1 1 0 Dapper Spt20 PF12090.8 CDI87174.1 - 0.38 10.3 5.8 0.85 9.2 5.8 1.6 1 0 0 1 1 1 0 Spt20 family SKA1 PF07160.12 CDI87175.1 - 0.065 13.1 6.0 0.15 11.9 6.0 1.7 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF1635 PF07795.11 CDI87175.1 - 0.13 12.1 9.7 0.32 10.8 9.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Zip PF02535.22 CDI87175.1 - 0.15 11.3 3.1 0.21 10.7 3.1 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF755 PF05501.11 CDI87175.1 - 0.33 11.2 20.2 1 9.7 19.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF755) CCDC84 PF14968.6 CDI87175.1 - 4.7 6.8 15.4 10 5.6 15.3 1.8 1 1 0 1 1 1 0 Coiled coil protein 84 ALMT PF11744.8 CDI87175.1 - 5 5.9 9.3 6.3 5.5 9.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter SPX PF03105.19 CDI87175.1 - 6.6 6.5 31.9 0.023 14.7 14.1 2.4 1 1 0 2 2 2 0 SPX domain Apt1 PF10351.9 CDI87176.1 - 2.2 7.0 29.4 2.8 6.7 29.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain FAM76 PF16046.5 CDI87176.1 - 8 5.7 12.4 10 5.4 12.4 1.2 1 0 0 1 1 1 0 FAM76 protein CDC45 PF02724.14 CDI87177.1 - 0.012 13.9 11.3 0.012 14.0 11.3 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI87177.1 - 0.026 13.5 18.5 0.026 13.5 18.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF572 PF04502.13 CDI87177.1 - 0.033 13.8 15.2 0.034 13.8 15.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) SpoIIP PF07454.11 CDI87177.1 - 0.034 13.6 16.5 0.047 13.1 16.5 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) N6_N4_Mtase PF01555.18 CDI87177.1 - 0.039 13.7 0.0 0.13 12.0 0.0 1.8 1 1 0 1 1 1 0 DNA methylase FAM60A PF15396.6 CDI87177.1 - 0.044 13.8 11.9 0.048 13.7 11.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A CCSAP PF15748.5 CDI87177.1 - 0.048 13.8 18.8 0.054 13.7 18.8 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4746 PF15928.5 CDI87177.1 - 0.079 12.4 10.6 0.087 12.2 10.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Zip PF02535.22 CDI87177.1 - 0.085 12.1 4.8 0.091 12.0 4.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Draxin PF15550.6 CDI87177.1 - 0.099 12.5 10.3 0.1 12.4 10.3 1.2 1 0 0 1 1 1 0 Draxin Otopetrin PF03189.13 CDI87177.1 - 0.11 11.2 6.4 0.11 11.3 6.4 1.2 1 0 0 1 1 1 0 Otopetrin Peptidase_S64 PF08192.11 CDI87177.1 - 0.12 10.9 12.9 0.12 10.8 12.9 1.2 1 0 0 1 1 1 0 Peptidase family S64 Velvet PF11754.8 CDI87177.1 - 0.16 11.8 14.8 0.19 11.6 14.8 1.2 1 0 0 1 1 1 0 Velvet factor ALMT PF11744.8 CDI87177.1 - 0.2 10.4 19.1 0.29 9.9 19.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter eIF3_subunit PF08597.10 CDI87177.1 - 0.25 11.2 21.8 0.4 10.5 21.8 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit GREB1 PF15782.5 CDI87177.1 - 0.3 8.2 18.6 0.3 8.1 18.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Membralin PF09746.9 CDI87177.1 - 0.42 9.6 13.2 0.42 9.6 13.2 1.2 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 CDI87177.1 - 0.65 8.7 25.5 0.8 8.4 25.5 1.2 1 0 0 1 1 1 0 Presenilin MDM10 PF12519.8 CDI87177.1 - 0.68 8.7 15.9 0.71 8.7 15.9 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 NARP1 PF12569.8 CDI87177.1 - 0.7 8.7 26.8 0.56 9.1 22.8 1.9 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 ASC PF00858.24 CDI87177.1 - 0.9 8.4 12.9 1.1 8.1 12.9 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Plasmodium_Vir PF05795.11 CDI87177.1 - 1.4 8.3 8.2 1.5 8.2 8.2 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Ndc1_Nup PF09531.10 CDI87177.1 - 1.5 7.5 17.0 1.6 7.4 17.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Sin_N PF04801.13 CDI87177.1 - 1.6 7.8 36.7 2.1 7.5 36.7 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region HCO3_cotransp PF00955.21 CDI87177.1 - 1.8 7.3 9.8 2.6 6.8 9.8 1.3 1 0 0 1 1 1 0 HCO3- transporter family PAT1 PF09770.9 CDI87177.1 - 2.6 6.2 38.4 2.9 6.0 38.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 CDI87177.1 - 2.8 8.0 19.4 3.9 7.5 19.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ureide_permease PF07168.11 CDI87177.1 - 3.1 6.5 8.5 4.6 5.9 8.5 1.4 1 0 0 1 1 1 0 Ureide permease DUF2370 PF10176.9 CDI87177.1 - 3.4 7.2 10.9 5.3 6.6 10.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Tim54 PF11711.8 CDI87177.1 - 3.6 6.3 16.6 4.9 5.8 16.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PPL5 PF18168.1 CDI87177.1 - 3.7 6.8 16.5 5.6 6.2 16.5 1.3 1 0 0 1 1 1 0 Prim-pol family 5 CAF1 PF04857.20 CDI87177.1 - 3.9 6.6 13.8 4.2 6.4 13.8 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease Gti1_Pac2 PF09729.9 CDI87177.1 - 4.4 7.4 18.1 7.2 6.7 18.1 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family Rrn6 PF10214.9 CDI87177.1 - 4.4 5.7 28.0 4.8 5.6 28.0 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SID-1_RNA_chan PF13965.6 CDI87177.1 - 4.6 5.5 9.4 4.9 5.4 9.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4638 PF15472.6 CDI87177.1 - 5.3 6.7 21.3 7.6 6.2 21.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) RNA_pol_Rpb1_5 PF04998.17 CDI87177.1 - 5.9 6.2 9.0 7.5 5.9 9.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Cellulose_synt PF03552.14 CDI87177.1 - 7.8 4.8 10.3 9.2 4.6 10.3 1.1 1 0 0 1 1 1 0 Cellulose synthase Glyco_transf_41 PF13844.6 CDI87177.1 - 8.7 4.6 11.9 11 4.4 11.9 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 WD40 PF00400.32 CDI87178.1 - 0.00014 22.6 0.2 1.3 10.1 0.0 3.4 3 0 0 3 3 3 1 WD domain, G-beta repeat eIF-3_zeta PF05091.12 CDI87178.1 - 0.01 14.9 9.7 0.013 14.5 9.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MecA PF05389.12 CDI87178.1 - 0.023 14.4 8.6 0.031 13.9 8.6 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Nop53 PF07767.11 CDI87178.1 - 0.031 13.7 15.9 0.041 13.3 15.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Neur_chan_memb PF02932.16 CDI87178.1 - 0.049 13.7 5.8 0.059 13.4 5.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EOS1 PF12326.8 CDI87178.1 - 0.08 12.9 0.4 0.092 12.7 0.4 1.2 1 0 0 1 1 1 0 N-glycosylation protein Baculo_PP31 PF05311.11 CDI87178.1 - 0.09 12.3 10.1 0.12 11.8 10.1 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Spt20 PF12090.8 CDI87178.1 - 0.26 10.9 32.9 0.39 10.3 32.9 1.3 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI87178.1 - 0.28 11.2 27.6 0.35 10.8 27.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hid1 PF12722.7 CDI87178.1 - 0.29 9.2 11.4 0.35 8.9 11.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PBP_sp32 PF07222.12 CDI87178.1 - 0.34 10.3 15.3 0.48 9.8 15.3 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Folate_carrier PF01770.18 CDI87178.1 - 0.34 9.6 5.3 0.49 9.1 5.3 1.2 1 0 0 1 1 1 0 Reduced folate carrier DDHD PF02862.17 CDI87178.1 - 0.35 11.0 10.0 0.49 10.5 10.0 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 CDI87178.1 - 0.4 9.4 13.0 0.52 9.0 13.0 1.1 1 0 0 1 1 1 0 Presenilin DUF1644 PF07800.12 CDI87178.1 - 0.42 10.7 10.0 0.35 10.9 7.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) TMEM51 PF15345.6 CDI87178.1 - 0.45 10.3 11.7 0.66 9.8 11.7 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 RR_TM4-6 PF06459.12 CDI87178.1 - 0.47 10.2 10.5 0.72 9.6 10.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Suf PF05843.14 CDI87178.1 - 0.53 10.2 14.7 0.76 9.7 14.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PIP5K PF01504.18 CDI87178.1 - 0.58 9.3 8.0 0.91 8.7 8.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Connexin PF00029.19 CDI87178.1 - 0.71 9.6 7.9 1 9.1 7.9 1.2 1 0 0 1 1 1 0 Connexin Nucleoside_tran PF01733.18 CDI87178.1 - 0.73 9.2 2.0 0.93 8.8 2.0 1.1 1 0 0 1 1 1 0 Nucleoside transporter Pex14_N PF04695.13 CDI87178.1 - 0.8 10.3 19.6 1.2 9.7 19.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Peroxin-13_N PF04088.13 CDI87178.1 - 0.88 9.8 6.6 1.3 9.3 6.6 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Coilin_N PF15862.5 CDI87178.1 - 0.99 9.2 14.0 1.6 8.5 14.0 1.4 1 0 0 1 1 1 0 Coilin N-terminus EPL1 PF10513.9 CDI87178.1 - 1 9.8 14.6 1.8 8.9 14.6 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like SpoIIP PF07454.11 CDI87178.1 - 1 8.8 12.3 1.4 8.3 12.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4175 PF13779.6 CDI87178.1 - 1 7.2 25.6 1.2 6.9 25.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SPT16 PF08644.11 CDI87178.1 - 1.2 9.3 9.4 1.7 8.8 9.4 1.2 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) EIIBC-GUT_N PF03612.14 CDI87178.1 - 1.5 8.5 10.0 2.2 8.0 10.0 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Orf78 PF06024.12 CDI87178.1 - 1.5 9.1 6.8 2.6 8.4 6.8 1.3 1 0 0 1 1 1 0 Orf78 (ac78) V_ATPase_I PF01496.19 CDI87178.1 - 2.3 6.0 11.4 3 5.7 11.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI87178.1 - 3.4 6.6 8.4 5.2 6.0 8.4 1.2 1 0 0 1 1 1 0 CLN3 protein TERB2 PF15101.6 CDI87178.1 - 4 7.4 17.5 6.7 6.7 17.5 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 AIF_C PF14721.6 CDI87178.1 - 4 7.8 8.3 6.5 7.1 8.3 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CPSF100_C PF13299.6 CDI87178.1 - 4 7.6 11.8 6 7.0 11.8 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Peptidase_S49_N PF08496.10 CDI87178.1 - 4.1 7.4 10.8 6.2 6.9 10.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Serinc PF03348.15 CDI87178.1 - 4.9 6.0 5.7 6.5 5.6 5.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4834 PF16118.5 CDI87178.1 - 5.5 8.0 15.5 11 7.1 15.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) ALMT PF11744.8 CDI87178.1 - 6.6 5.4 8.5 8.3 5.1 8.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Conotoxin PF02950.17 CDI87178.1 - 7 7.7 6.9 21 6.2 6.9 1.8 1 0 0 1 1 1 0 Conotoxin Herpes_DNAp_acc PF04929.12 CDI87178.1 - 8.4 5.2 13.0 12 4.7 13.0 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor OATP PF03137.20 CDI87178.1 - 9.4 4.4 8.5 16 3.6 8.5 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Folliculin PF11704.8 CDI87178.1 - 9.6 6.0 10.3 14 5.5 10.3 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport MACPF PF01823.19 CDI87179.1 - 3.6e-24 86.0 0.0 3.6e-24 86.0 0.0 5.2 3 1 2 5 5 5 1 MAC/Perforin domain FHIPEP PF00771.20 CDI87179.1 - 0.012 14.1 8.4 0.015 13.8 2.9 2.3 2 0 0 2 2 2 0 FHIPEP family TFIIA PF03153.13 CDI87179.1 - 0.48 10.4 85.1 0.11 12.4 59.3 2.3 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit O-antigen_lig PF13425.6 CDI87179.1 - 5.4 5.7 7.7 13 4.5 2.2 2.1 2 0 0 2 2 2 0 O-antigen ligase like membrane protein D123 PF07065.14 CDI87180.1 - 0.005 16.0 5.8 0.0055 15.9 5.8 1.0 1 0 0 1 1 1 1 D123 FAM176 PF14851.6 CDI87180.1 - 0.0072 16.0 4.6 0.0081 15.8 4.6 1.1 1 0 0 1 1 1 1 FAM176 family DUF4366 PF14283.6 CDI87180.1 - 0.026 14.6 2.8 0.03 14.4 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Kei1 PF08552.11 CDI87180.1 - 0.043 13.7 3.5 0.048 13.5 3.5 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 ESM4 PF15952.5 CDI87180.1 - 0.045 14.2 17.9 0.047 14.1 17.9 1.0 1 0 0 1 1 1 0 Enhancer of split M4 family Presenilin PF01080.17 CDI87180.1 - 0.057 12.2 9.3 0.056 12.2 9.3 1.1 1 0 0 1 1 1 0 Presenilin DUF2370 PF10176.9 CDI87180.1 - 0.061 13.0 3.0 0.061 13.0 3.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Pex14_N PF04695.13 CDI87180.1 - 0.077 13.6 11.7 0.08 13.6 11.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PDEase_I_N PF08499.12 CDI87180.1 - 0.094 12.6 1.3 0.2 11.5 1.3 1.8 1 1 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal DUF3464 PF11947.8 CDI87180.1 - 0.13 12.0 8.2 0.14 12.0 8.2 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 TERB2 PF15101.6 CDI87180.1 - 0.17 11.9 15.0 0.16 12.0 15.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4337 PF14235.6 CDI87180.1 - 0.18 11.9 8.6 0.19 11.9 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Connexin PF00029.19 CDI87180.1 - 0.24 11.1 7.4 0.23 11.2 7.4 1.0 1 0 0 1 1 1 0 Connexin FemAB PF02388.16 CDI87180.1 - 0.26 10.1 11.7 0.28 10.0 11.7 1.0 1 0 0 1 1 1 0 FemAB family AIF_C PF14721.6 CDI87180.1 - 0.27 11.6 5.7 0.29 11.5 5.7 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CrgA PF06781.12 CDI87180.1 - 0.28 11.3 2.8 0.98 9.5 2.8 1.8 1 1 0 1 1 1 0 Cell division protein CrgA EOS1 PF12326.8 CDI87180.1 - 0.36 10.8 2.0 0.38 10.7 2.0 1.1 1 0 0 1 1 1 0 N-glycosylation protein Spt20 PF12090.8 CDI87180.1 - 0.39 10.3 32.5 0.44 10.1 32.5 1.1 1 0 0 1 1 1 0 Spt20 family DUF4746 PF15928.5 CDI87180.1 - 0.52 9.7 12.1 0.54 9.6 12.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Tim54 PF11711.8 CDI87180.1 - 0.61 8.8 10.4 0.64 8.8 10.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4820 PF16091.5 CDI87180.1 - 0.62 9.4 10.6 0.7 9.2 10.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Neur_chan_memb PF02932.16 CDI87180.1 - 0.82 9.7 6.5 0.83 9.7 6.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region UPF0524 PF15823.5 CDI87180.1 - 0.85 9.0 5.8 0.94 8.8 5.8 1.1 1 0 0 1 1 1 0 UPF0524 of C3orf70 Eapp_C PF10238.9 CDI87180.1 - 0.87 9.7 10.5 0.9 9.6 10.5 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein Ureide_permease PF07168.11 CDI87180.1 - 0.9 8.2 3.8 0.92 8.2 3.8 1.0 1 0 0 1 1 1 0 Ureide permease Pox_Ag35 PF03286.14 CDI87180.1 - 1.1 9.0 7.8 1.2 8.9 7.8 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein OATP PF03137.20 CDI87180.1 - 1.2 7.3 3.9 1.2 7.4 3.9 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SpoIIP PF07454.11 CDI87180.1 - 1.2 8.5 13.1 1.2 8.5 13.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CCDC53 PF10152.9 CDI87180.1 - 1.4 9.4 13.4 1.4 9.3 13.4 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex CagX PF03524.15 CDI87180.1 - 1.5 8.5 8.3 1.5 8.5 8.3 1.1 1 0 0 1 1 1 0 Conjugal transfer protein PPL5 PF18168.1 CDI87180.1 - 1.5 8.0 6.1 1.5 8.0 6.1 1.0 1 0 0 1 1 1 0 Prim-pol family 5 RNA_pol_Rbc25 PF08292.12 CDI87180.1 - 1.7 8.9 8.4 2.1 8.6 8.4 1.2 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 DUF5336 PF17270.2 CDI87180.1 - 1.8 8.2 14.7 5.9 6.5 14.7 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF5336) EIIBC-GUT_N PF03612.14 CDI87180.1 - 1.9 8.2 10.8 2 8.1 10.8 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Gti1_Pac2 PF09729.9 CDI87180.1 - 2.3 8.3 7.3 2.3 8.3 7.3 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family MCU PF04678.13 CDI87180.1 - 2.5 8.2 9.3 2.7 8.0 9.3 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter PIP5K PF01504.18 CDI87180.1 - 2.6 7.2 9.8 2.8 7.1 9.8 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase UPF0560 PF10577.9 CDI87180.1 - 2.8 6.4 19.1 2.7 6.4 19.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 CPSF100_C PF13299.6 CDI87180.1 - 2.8 8.1 8.9 2.9 8.0 8.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DDHD PF02862.17 CDI87180.1 - 3 8.0 9.2 2.9 8.0 9.2 1.1 1 0 0 1 1 1 0 DDHD domain V_ATPase_I PF01496.19 CDI87180.1 - 3.1 5.6 13.2 3.2 5.6 13.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI87180.1 - 3.3 6.7 7.7 3.2 6.7 7.7 1.1 1 0 0 1 1 1 0 CLN3 protein Ctr PF04145.15 CDI87180.1 - 3.4 8.3 5.1 3.6 8.2 5.1 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Suf PF05843.14 CDI87180.1 - 3.5 7.5 12.2 3.5 7.5 12.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Sec62 PF03839.16 CDI87180.1 - 3.5 7.1 6.9 3.6 7.0 6.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Orf78 PF06024.12 CDI87180.1 - 3.5 8.0 6.4 7.6 6.9 6.4 1.6 1 1 0 1 1 1 0 Orf78 (ac78) Zip PF02535.22 CDI87180.1 - 3.6 6.7 6.7 3.7 6.7 6.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2126 PF09899.9 CDI87180.1 - 3.8 5.5 8.0 3.8 5.5 8.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) SID-1_RNA_chan PF13965.6 CDI87180.1 - 4.4 5.6 5.9 4.3 5.6 5.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI87180.1 - 4.7 6.0 5.5 4.4 6.1 5.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF1980 PF09323.10 CDI87180.1 - 5.8 6.8 8.1 5.8 6.8 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) LIM_bind PF01803.16 CDI87180.1 - 5.9 6.3 12.5 6.2 6.3 12.5 1.1 1 0 0 1 1 1 0 LIM-domain binding protein TFB6 PF17110.5 CDI87180.1 - 6.2 6.5 9.1 6.4 6.5 9.1 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH SLC12 PF03522.15 CDI87180.1 - 6.8 5.6 10.8 7 5.6 10.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF2722 PF10846.8 CDI87180.1 - 7.7 5.3 26.1 8.1 5.3 26.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pex26 PF07163.12 CDI87180.1 - 8.1 5.7 10.3 8.9 5.5 10.3 1.1 1 0 0 1 1 1 0 Pex26 protein PepSY_TM PF03929.16 CDI87180.1 - 9.7 5.8 6.7 9.4 5.8 6.7 1.1 1 0 0 1 1 1 0 PepSY-associated TM region DUF755 PF05501.11 CDI87181.1 - 0.017 15.4 22.8 0.017 15.4 22.8 10.2 5 2 1 6 6 6 0 Domain of unknown function (DUF755) Helicase_C PF00271.31 CDI87182.1 - 0.00043 20.6 0.1 0.016 15.5 0.1 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DnaB_C PF03796.15 CDI87182.1 - 0.1 11.9 0.1 0.14 11.5 0.1 1.1 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain DHHA1 PF02272.19 CDI87182.1 - 0.77 10.2 7.7 0.61 10.5 6.0 1.7 2 0 0 2 2 2 0 DHHA1 domain Tic110 PF16940.5 CDI87182.1 - 1.4 7.3 4.9 1.8 6.9 4.9 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter SR-25 PF10500.9 CDI87182.1 - 2 8.0 12.3 3.3 7.3 12.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TMEM171 PF15471.6 CDI87182.1 - 2.1 7.2 4.1 4.9 6.1 0.9 2.1 2 0 0 2 2 2 0 Transmembrane protein family 171 DUF2722 PF10846.8 CDI87183.1 - 9.5e-05 21.5 9.6 0.00069 18.7 4.8 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) tRNA_synt_1c_R2 PF04557.15 CDI87183.1 - 0.022 15.7 4.5 1.4 9.9 0.1 2.6 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DUF4834 PF16118.5 CDI87183.1 - 0.028 15.4 2.3 0.67 11.0 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Guanylin PF02058.15 CDI87183.1 - 0.029 14.8 1.4 0.029 14.8 1.4 1.9 2 0 0 2 2 2 0 Guanylin precursor DUF4568 PF15132.6 CDI87183.1 - 0.075 12.4 5.1 0.14 11.5 5.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4568) 14-3-3 PF00244.20 CDI87183.1 - 0.29 10.6 2.6 0.21 11.0 0.2 1.8 2 0 0 2 2 2 0 14-3-3 protein Ndc1_Nup PF09531.10 CDI87183.1 - 0.56 8.8 5.8 0.71 8.5 5.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ashwin PF15323.6 CDI87185.1 - 0.059 13.4 19.6 0.073 13.1 19.6 1.1 1 0 0 1 1 1 0 Developmental protein CCSAP PF15748.5 CDI87185.1 - 0.14 12.3 17.7 0.19 11.9 17.7 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SpoIIIAH PF12685.7 CDI87185.1 - 0.56 10.0 20.1 2.9 7.7 20.1 1.8 1 1 0 1 1 1 0 SpoIIIAH-like protein SprA-related PF12118.8 CDI87185.1 - 1.3 8.1 26.0 1.6 7.8 26.0 1.1 1 0 0 1 1 1 0 SprA-related family PA26 PF04636.13 CDI87185.1 - 1.4 7.7 10.1 1.7 7.5 10.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Otopetrin PF03189.13 CDI87185.1 - 1.5 7.6 7.3 1.9 7.2 7.3 1.3 1 0 0 1 1 1 0 Otopetrin SSP160 PF06933.11 CDI87185.1 - 1.9 6.6 21.6 2 6.5 21.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 CLN3 PF02487.17 CDI87185.1 - 5 6.1 12.4 5.2e+02 -0.6 12.4 2.0 1 1 0 1 1 1 0 CLN3 protein EFTUD2 PF16004.5 CDI87185.1 - 9.2 6.9 15.1 5.3 7.7 1.4 2.1 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus RskA PF10099.9 CDI87186.1 - 0.003 17.9 30.7 3.4 7.9 30.1 2.8 1 1 1 2 2 2 1 Anti-sigma-K factor rskA Peptidase_S64 PF08192.11 CDI87186.1 - 0.16 10.4 29.6 0.19 10.2 29.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 RIFIN PF02009.16 CDI87186.1 - 0.28 11.0 24.8 0.36 10.7 24.8 1.1 1 0 0 1 1 1 0 Rifin SLC12 PF03522.15 CDI87186.1 - 0.38 9.7 32.1 0.63 9.0 32.1 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI87186.1 - 0.41 8.7 30.3 0.53 8.4 30.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SelP_N PF04592.14 CDI87186.1 - 0.44 9.9 27.2 0.83 9.0 27.2 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF572 PF04502.13 CDI87186.1 - 0.95 9.0 25.5 1.5 8.4 25.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) CAF1 PF04857.20 CDI87186.1 - 1.4 8.0 18.7 1.8 7.7 18.7 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease DNApol_Exo PF18136.1 CDI87186.1 - 1.5 7.8 20.9 3.3 6.8 20.9 1.5 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain DUF4045 PF13254.6 CDI87186.1 - 2.2 7.9 26.8 2.8 7.5 26.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) AbLIM_anchor PF16182.5 CDI87186.1 - 2.9 7.6 22.3 3.5 7.4 22.3 1.2 1 0 0 1 1 1 0 Putative adherens-junction anchoring region of AbLIM Ribosomal_60s PF00428.19 CDI87186.1 - 3.3 8.4 9.3 7.9 7.2 9.3 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Macoilin PF09726.9 CDI87186.1 - 6 5.3 29.5 8 4.9 29.5 1.1 1 0 0 1 1 1 0 Macoilin family PAT1 PF09770.9 CDI87186.1 - 8.6 4.5 55.8 13 3.9 55.8 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Sec16 PF12932.7 CDI87189.1 - 0.00032 21.3 0.1 0.00032 21.3 0.1 3.2 2 1 0 2 2 2 1 Vesicle coat trafficking protein Sec16 mid-region Sporozoite_P67 PF05642.11 CDI87189.1 - 0.017 13.2 27.7 0.031 12.4 20.0 2.2 2 0 0 2 2 2 0 Sporozoite P67 surface antigen SAGA-Tad1 PF12767.7 CDI87189.1 - 0.028 14.2 18.9 0.042 13.6 14.5 2.3 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit AF-4 PF05110.13 CDI87189.1 - 2 6.4 30.4 0.27 9.3 16.9 2.2 2 0 0 2 2 2 0 AF-4 proto-oncoprotein BORG_CEP PF14957.6 CDI87189.1 - 4.3 8.5 17.8 10 7.3 11.5 2.9 3 0 0 3 3 3 0 Cdc42 effector SID-1_RNA_chan PF13965.6 CDI87189.1 - 5.4 5.3 6.4 10 4.4 6.4 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Lin-8 PF03353.15 CDI87189.1 - 10 5.6 35.2 0.56 9.7 20.5 2.4 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist NrsF PF06532.11 CDI87190.1 - 0.012 15.3 3.7 0.012 15.3 3.7 2.7 3 0 0 3 3 3 0 Negative regulator of sigma F RskA PF10099.9 CDI87190.1 - 0.73 10.1 78.2 0.21 11.8 2.4 4.0 1 1 2 3 3 3 0 Anti-sigma-K factor rskA Trp_oprn_chp PF09534.10 CDI87190.1 - 4.3 7.1 40.4 0.12 12.1 5.5 3.1 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SUIM_assoc PF16619.5 CDI87191.1 - 9.8e-06 25.5 1.5 9.8e-06 25.5 1.5 4.2 2 1 1 3 3 2 1 Unstructured region C-term to UIM in Ataxin3 COPI_C PF06957.11 CDI87191.1 - 0.0098 14.7 6.4 0.0098 14.7 6.4 1.5 2 0 0 2 2 2 1 Coatomer (COPI) alpha subunit C-terminus EPL1 PF10513.9 CDI87191.1 - 0.12 12.8 14.3 0.79 10.1 7.6 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF2185 PF09951.9 CDI87191.1 - 0.12 12.2 0.8 0.2 11.5 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2185) PNISR PF15996.5 CDI87191.1 - 0.32 11.2 17.3 1.1 9.5 11.2 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Apc15p PF05841.11 CDI87191.1 - 0.34 11.7 24.8 0.89 10.4 13.9 2.3 2 0 0 2 2 2 0 Apc15p protein SAPS PF04499.15 CDI87191.1 - 0.42 9.3 5.0 0.63 8.8 5.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CPSF100_C PF13299.6 CDI87191.1 - 0.57 10.3 13.4 5.2 7.2 8.6 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF3807 PF12720.7 CDI87191.1 - 0.78 10.0 20.6 0.62 10.3 11.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Tim54 PF11711.8 CDI87191.1 - 1.9 7.2 16.7 3.8 6.2 11.5 2.0 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF913 PF06025.12 CDI87191.1 - 3.4 6.6 10.0 3.3 6.6 6.8 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) EloA-BP1 PF15870.5 CDI87191.1 - 3.4 7.9 8.6 0.25 11.6 3.0 1.8 2 0 0 2 2 2 0 ElonginA binding-protein 1 FAM176 PF14851.6 CDI87191.1 - 4.1 7.1 9.8 1.7 8.3 5.0 2.1 2 0 0 2 2 2 0 FAM176 family DUF966 PF06136.13 CDI87191.1 - 9 5.9 12.0 1.8 8.2 6.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF966) PP2C PF00481.21 CDI87192.1 - 1.1e-18 67.9 0.0 1.1e-18 67.9 0.0 2.8 2 2 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 CDI87192.1 - 0.018 15.0 0.1 0.018 15.0 0.1 2.2 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) UPF0225 PF17775.1 CDI87192.1 - 0.94 10.3 0.0 0.94 10.3 0.0 3.5 4 1 0 4 4 4 0 UPF0225 domain Metallophos PF00149.28 CDI87193.1 - 8.9e-06 26.3 0.1 5.4e-05 23.8 0.2 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase RVT_1 PF00078.27 CDI87194.1 - 3.6e-19 69.2 0.0 5.9e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 CDI87194.1 - 3e-10 40.6 0.0 6.3e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI87194.1 - 1.4e-09 38.4 0.0 2.9e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 CDI87194.1 - 2.3e-08 33.9 0.0 4e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 CDI87194.1 - 0.00084 19.1 0.0 0.0017 18.2 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 CDI87194.1 - 0.011 16.1 0.0 0.033 14.5 0.0 1.8 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF1758 PF05585.12 CDI87194.1 - 0.028 14.2 0.0 0.061 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative peptidase (DUF1758) Ribosomal_L22 PF00237.19 CDI87194.1 - 0.094 13.0 0.1 1.9 8.8 0.0 2.2 2 0 0 2 2 2 0 Ribosomal protein L22p/L17e Ribosomal_L37e PF01907.19 CDI87195.1 - 0.14 12.4 0.7 0.26 11.5 0.7 1.4 1 0 0 1 1 1 0 Ribosomal protein L37e DUF836 PF05768.14 CDI87195.1 - 0.14 12.6 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) She9_MDM33 PF05546.11 CDI87196.1 - 0.035 13.9 3.9 0.066 13.0 3.9 1.3 1 0 0 1 1 1 0 She9 / Mdm33 family ABC_tran_CTD PF16326.5 CDI87196.1 - 4.9 7.5 9.9 2 8.7 3.4 3.0 2 0 0 2 2 2 0 ABC transporter C-terminal domain MFS_1 PF07690.16 CDI87199.1 - 1e-12 47.7 19.7 1e-12 47.7 19.7 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily ERGIC_N PF13850.6 CDI87199.1 - 0.016 15.6 1.3 0.12 12.8 0.4 2.5 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) RhlB PF12300.8 CDI87200.1 - 0.1 12.7 0.1 0.14 12.3 0.1 1.1 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB DUF4834 PF16118.5 CDI87201.1 - 0.018 16.0 10.6 0.018 16.0 10.6 4.0 2 2 1 3 3 3 0 Domain of unknown function (DUF4834) DUF2828 PF11443.8 CDI87201.1 - 0.08 11.0 16.7 0.0065 14.6 9.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) DUF572 PF04502.13 CDI87201.1 - 0.093 12.3 23.0 0.013 15.2 11.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) SLC12 PF03522.15 CDI87201.1 - 0.28 10.2 26.9 0.077 12.0 16.1 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Nop53 PF07767.11 CDI87201.1 - 2.3 7.5 40.3 0.066 12.6 27.7 2.4 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) LicD PF04991.13 CDI87201.1 - 6 6.9 15.3 0.36 10.9 8.7 1.9 2 0 0 2 2 2 0 LicD family Fumble PF03630.14 CDI87201.1 - 9.8 5.2 9.9 0.46 9.6 3.6 1.9 2 0 0 2 2 2 0 Fumble Hamartin PF04388.12 CDI87202.1 - 0.049 12.3 28.5 0.051 12.2 28.5 1.0 1 0 0 1 1 1 0 Hamartin protein DUF5427 PF10310.9 CDI87202.1 - 1 8.2 37.3 1.4 7.7 37.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) PAP2_3 PF14378.6 CDI87202.1 - 1.4 8.6 7.6 0.16 11.6 3.3 1.6 1 1 1 2 2 2 0 PAP2 superfamily DDRGK PF09756.9 CDI87202.1 - 3.5 7.2 32.3 1.3 8.6 4.1 2.1 2 0 0 2 2 2 0 DDRGK domain DUF4207 PF13904.6 CDI87202.1 - 3.6 7.2 52.4 6.1 6.5 52.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) SAPS PF04499.15 CDI87202.1 - 5.9 5.5 23.8 7.5 5.2 23.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SOBP PF15279.6 CDI87203.1 - 0.0029 18.3 35.0 0.0033 18.1 35.0 1.0 1 0 0 1 1 1 1 Sine oculis-binding protein THRAP3_BCLAF1 PF15440.6 CDI87203.1 - 0.035 13.1 47.6 0.044 12.8 47.6 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family CDC45 PF02724.14 CDI87203.1 - 0.12 10.7 23.0 0.13 10.6 23.0 1.2 1 0 0 1 1 1 0 CDC45-like protein DDRGK PF09756.9 CDI87203.1 - 0.17 11.4 23.3 0.24 11.0 23.3 1.2 1 0 0 1 1 1 0 DDRGK domain DUF4746 PF15928.5 CDI87203.1 - 0.18 11.2 14.0 0.21 10.9 14.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) VIT1 PF01988.19 CDI87203.1 - 0.25 11.2 23.1 0.36 10.7 23.1 1.3 1 0 0 1 1 1 0 VIT family PAT1 PF09770.9 CDI87203.1 - 0.4 8.9 38.8 0.44 8.8 38.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LMBR1 PF04791.16 CDI87203.1 - 0.44 9.4 12.6 0.53 9.1 12.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein SDH_alpha PF03313.15 CDI87203.1 - 0.58 9.8 31.8 0.75 9.4 31.8 1.1 1 0 0 1 1 1 0 Serine dehydratase alpha chain Membralin PF09746.9 CDI87203.1 - 1.5 7.8 15.0 1.7 7.6 15.0 1.3 1 0 0 1 1 1 0 Tumour-associated protein DUF4551 PF15087.6 CDI87203.1 - 1.6 7.4 24.9 1.8 7.3 24.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF5523 PF17661.1 CDI87203.1 - 1.8 8.2 22.9 2.7 7.6 22.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) PPP4R2 PF09184.11 CDI87203.1 - 1.9 8.0 25.0 2.3 7.8 25.0 1.2 1 0 0 1 1 1 0 PPP4R2 Asp-B-Hydro_N PF05279.11 CDI87203.1 - 2 8.4 14.9 2.4 8.2 14.9 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region GREB1 PF15782.5 CDI87203.1 - 3.1 4.8 40.8 3.3 4.7 40.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Cellulose_synt PF03552.14 CDI87203.1 - 5.6 5.3 11.5 6.7 5.1 11.5 1.1 1 0 0 1 1 1 0 Cellulose synthase Peptidase_S49_N PF08496.10 CDI87203.1 - 7 6.7 17.5 16 5.6 17.5 1.7 1 0 0 1 1 1 0 Peptidase family S49 N-terminal AAA_23 PF13476.6 CDI87203.1 - 9.3 6.7 23.5 13 6.2 23.5 1.2 1 0 0 1 1 1 0 AAA domain RskA PF10099.9 CDI87204.1 - 0.00068 20.0 11.5 0.00088 19.6 11.5 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI87204.1 - 0.0024 17.5 20.5 0.0027 17.3 20.5 1.2 1 0 0 1 1 1 1 Spt20 family DUF755 PF05501.11 CDI87204.1 - 0.0025 18.1 22.0 0.0034 17.6 22.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF755) MMR1 PF08505.10 CDI87204.1 - 0.021 15.2 15.7 0.024 15.0 15.7 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein CCDC71L PF15374.6 CDI87204.1 - 0.035 13.4 15.6 0.04 13.2 15.6 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L NEMP PF10225.9 CDI87204.1 - 0.037 13.7 3.7 0.042 13.5 3.7 1.0 1 0 0 1 1 1 0 NEMP family TFIIA PF03153.13 CDI87204.1 - 0.059 13.4 23.2 0.07 13.1 23.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spore_coat_CotO PF14153.6 CDI87204.1 - 0.093 12.7 17.7 0.11 12.4 17.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Myc_N PF01056.18 CDI87204.1 - 0.1 12.5 13.2 0.12 12.3 13.2 1.0 1 0 0 1 1 1 0 Myc amino-terminal region MAP65_ASE1 PF03999.12 CDI87204.1 - 0.18 10.5 14.0 0.21 10.2 14.0 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) CDC45 PF02724.14 CDI87204.1 - 0.23 9.7 15.9 0.25 9.6 15.9 1.0 1 0 0 1 1 1 0 CDC45-like protein TERB2 PF15101.6 CDI87204.1 - 0.27 11.3 10.5 0.32 11.0 10.5 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF908 PF06012.12 CDI87204.1 - 0.45 9.9 13.0 0.47 9.8 13.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) DUF4603 PF15376.6 CDI87204.1 - 0.48 7.8 13.8 0.53 7.6 13.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) UPF0560 PF10577.9 CDI87204.1 - 0.54 8.7 10.7 0.6 8.5 10.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Plasmodium_Vir PF05795.11 CDI87204.1 - 0.56 9.6 12.4 0.63 9.4 12.4 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Lin-8 PF03353.15 CDI87204.1 - 0.59 9.6 15.7 0.65 9.5 15.7 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF3807 PF12720.7 CDI87204.1 - 0.62 10.3 22.3 0.77 10.0 22.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) GREB1 PF15782.5 CDI87204.1 - 0.63 7.1 15.7 0.68 7.0 15.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF913 PF06025.12 CDI87204.1 - 0.7 8.8 11.8 0.79 8.6 11.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3450 PF11932.8 CDI87204.1 - 0.73 9.1 17.1 0.88 8.8 17.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4692 PF15763.5 CDI87204.1 - 0.79 10.2 9.4 0.94 9.9 9.4 1.2 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Vfa1 PF08432.10 CDI87204.1 - 0.8 10.0 17.1 0.99 9.7 17.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC27 PF09507.10 CDI87204.1 - 0.95 8.8 21.1 1.1 8.5 21.1 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF4179 PF13786.6 CDI87204.1 - 0.99 9.9 5.3 1.2 9.6 5.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) IHABP4_N PF16174.5 CDI87204.1 - 1.1 9.8 22.1 1.5 9.4 22.1 1.1 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal MPM1 PF17234.2 CDI87204.1 - 1.3 9.2 15.3 1.8 8.8 15.3 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 API5 PF05918.11 CDI87204.1 - 1.5 7.6 13.8 1.8 7.3 13.8 1.3 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Dehydrin PF00257.19 CDI87204.1 - 1.6 9.2 19.7 2.9 8.4 19.7 1.4 1 1 0 1 1 1 0 Dehydrin Tim54 PF11711.8 CDI87204.1 - 1.8 7.3 12.7 2.2 7.0 12.7 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SPATIAL PF15256.6 CDI87204.1 - 2 8.7 11.0 2.8 8.2 11.0 1.2 1 0 0 1 1 1 0 SPATIAL BORG_CEP PF14957.6 CDI87204.1 - 2 9.6 10.8 2.5 9.3 10.8 1.2 1 0 0 1 1 1 0 Cdc42 effector eIF3_subunit PF08597.10 CDI87204.1 - 2.2 8.1 21.9 2.6 7.9 21.9 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit RPN2_C PF18004.1 CDI87204.1 - 2.2 8.2 15.1 2.8 7.9 15.1 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF2052 PF09747.9 CDI87204.1 - 2.2 8.3 17.6 2.7 8.1 17.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Apt1 PF10351.9 CDI87204.1 - 2.3 7.0 15.4 2.6 6.8 15.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain FAM60A PF15396.6 CDI87204.1 - 2.5 8.1 11.3 3 7.8 11.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Asp-B-Hydro_N PF05279.11 CDI87204.1 - 2.5 8.1 13.8 2.8 7.9 13.8 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF3367 PF11847.8 CDI87204.1 - 2.5 5.8 10.0 3 5.6 10.0 1.0 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase TRAP_alpha PF03896.16 CDI87204.1 - 2.7 7.1 9.5 3 7.0 9.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PAT1 PF09770.9 CDI87204.1 - 3.1 6.0 17.8 3.2 5.9 17.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Roughex PF06020.11 CDI87204.1 - 3.3 6.7 14.5 4.2 6.4 14.5 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Herpes_UL25 PF01499.16 CDI87204.1 - 3.5 6.0 12.4 4 5.9 12.4 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family Med24_N PF11277.8 CDI87204.1 - 3.8 5.4 8.6 4.3 5.2 8.6 1.0 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal DUF966 PF06136.13 CDI87204.1 - 3.9 7.1 15.5 4.4 6.9 15.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Band_3_cyto PF07565.13 CDI87204.1 - 4 7.2 9.5 4.6 7.0 9.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain eIF-3_zeta PF05091.12 CDI87204.1 - 4 6.3 15.2 4.4 6.2 15.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SRP-alpha_N PF04086.13 CDI87204.1 - 4.1 7.2 20.6 4.8 7.0 20.6 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal BSP_II PF05432.11 CDI87204.1 - 4.1 7.0 19.1 4.9 6.8 19.1 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DDHD PF02862.17 CDI87204.1 - 4.7 7.3 14.0 7.3 6.7 14.0 1.3 1 0 0 1 1 1 0 DDHD domain SLC12 PF03522.15 CDI87204.1 - 5 6.0 15.0 5.4 5.9 15.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 O-antigen_lig PF13425.6 CDI87204.1 - 5.1 5.8 5.1 5.4 5.7 5.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Suf PF05843.14 CDI87204.1 - 6 6.8 13.0 8.2 6.3 13.0 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CLN3 PF02487.17 CDI87204.1 - 6 5.8 8.5 6.8 5.6 8.5 1.1 1 0 0 1 1 1 0 CLN3 protein PA26 PF04636.13 CDI87204.1 - 6.2 5.6 10.4 7.3 5.4 10.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) LAP1C PF05609.12 CDI87204.1 - 6.3 5.8 16.5 7.3 5.6 16.5 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RR_TM4-6 PF06459.12 CDI87204.1 - 7.2 6.4 17.6 8.3 6.1 17.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PepSY_TM PF03929.16 CDI87204.1 - 7.2 6.2 6.6 9.1 5.9 6.6 1.2 1 0 0 1 1 1 0 PepSY-associated TM region RAB3GAP2_N PF14655.6 CDI87204.1 - 7.4 5.7 10.4 3.5 6.8 9.0 1.3 1 1 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Mem_trans PF03547.18 CDI87204.1 - 7.5 4.8 9.5 9 4.6 9.5 1.1 1 0 0 1 1 1 0 Membrane transport protein Sec62 PF03839.16 CDI87204.1 - 8 5.9 9.4 8.5 5.8 9.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Folliculin PF11704.8 CDI87204.1 - 8.4 6.2 11.0 11 5.9 11.0 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF4746 PF15928.5 CDI87204.1 - 8.4 5.7 10.7 8.8 5.7 10.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TMEM171 PF15471.6 CDI87205.1 - 0.075 12.0 2.3 0.068 12.2 1.1 1.6 1 1 0 1 1 1 0 Transmembrane protein family 171 UPF0560 PF10577.9 CDI87205.1 - 1.2 7.6 14.3 5.3 5.4 0.2 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 EPL1 PF10513.9 CDI87205.1 - 3.2 8.1 9.5 0.32 11.4 1.6 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF5523 PF17661.1 CDI87206.1 - 6.3 6.4 22.8 7.1 6.2 22.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) AF-4 PF05110.13 CDI87207.1 - 1.3e-05 23.6 37.1 1.3e-05 23.6 37.1 3.1 2 1 0 3 3 3 1 AF-4 proto-oncoprotein DHQS PF01959.16 CDI87207.1 - 0.052 12.4 2.1 0.11 11.4 2.1 1.4 1 0 0 1 1 1 0 3-dehydroquinate synthase II SARAF PF06682.12 CDI87210.1 - 0.013 15.2 26.6 0.016 14.9 26.6 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Orf78 PF06024.12 CDI87210.1 - 0.023 15.0 3.7 0.023 15.0 3.7 3.0 1 1 1 3 3 3 0 Orf78 (ac78) PIEZO PF15917.5 CDI87210.1 - 1.4 8.3 40.5 0.71 9.3 24.6 2.0 2 0 0 2 2 2 0 Piezo Peptidase_M56 PF05569.11 CDI87210.1 - 8.5 5.5 11.5 4.6 6.3 9.8 1.4 1 1 0 1 1 1 0 BlaR1 peptidase M56 AF-4 PF05110.13 CDI87212.1 - 0.35 8.9 65.0 0.52 8.3 65.0 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein zf-C4H2 PF10146.9 CDI87213.1 - 0.03 14.7 3.7 0.034 14.5 3.7 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein NPR3 PF03666.13 CDI87213.1 - 0.039 12.7 4.7 0.054 12.3 4.7 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 CDI87213.1 - 0.05 12.4 7.7 0.052 12.3 7.7 1.4 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 CDI87213.1 - 0.23 10.4 4.6 0.37 9.7 4.6 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Membralin PF09746.9 CDI87213.1 - 0.49 9.4 4.1 0.67 8.9 4.1 1.1 1 0 0 1 1 1 0 Tumour-associated protein SKA1 PF07160.12 CDI87213.1 - 0.62 9.9 12.0 1 9.1 12.0 1.4 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF572 PF04502.13 CDI87213.1 - 0.76 9.3 13.0 0.91 9.1 13.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) FlaC_arch PF05377.11 CDI87213.1 - 0.87 10.0 2.8 0.92 9.9 0.0 2.3 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) V_ATPase_I PF01496.19 CDI87213.1 - 1.2 7.0 9.9 1.8 6.4 9.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RNA_pol_Rpc4 PF05132.14 CDI87213.1 - 1.5 9.3 9.4 1.1 9.7 5.6 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 Hamartin PF04388.12 CDI87213.1 - 1.7 7.2 11.9 1.9 7.1 11.9 1.1 1 0 0 1 1 1 0 Hamartin protein SAPS PF04499.15 CDI87213.1 - 2.2 7.0 8.2 2.8 6.6 8.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein LMBR1 PF04791.16 CDI87213.1 - 3.1 6.6 7.7 3.9 6.3 7.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Hid1 PF12722.7 CDI87213.1 - 7.7 4.5 12.5 8.1 4.4 12.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Caldesmon PF02029.15 CDI87216.1 - 7.7 5.2 95.9 0.41 9.3 55.3 3.1 3 0 0 3 3 3 0 Caldesmon HTH_23 PF13384.6 CDI87217.1 - 0.0002 21.0 0.1 0.0017 18.1 0.1 2.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 CDI87217.1 - 0.0027 17.8 0.2 0.0027 17.8 0.2 5.4 4 0 0 4 4 4 1 Helix-turn-helix domain DUF4207 PF13904.6 CDI87218.1 - 1.8 8.2 27.6 3.9 7.1 27.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) Peptidase_S64 PF08192.11 CDI87218.1 - 2.1 6.7 26.6 3.1 6.2 26.6 1.3 1 0 0 1 1 1 0 Peptidase family S64 SOBP PF15279.6 CDI87218.1 - 5.6 7.5 18.8 10 6.7 18.8 1.5 1 0 0 1 1 1 0 Sine oculis-binding protein SR-25 PF10500.9 CDI87219.1 - 0.11 12.1 48.9 0.15 11.6 12.0 3.4 1 1 2 3 3 3 0 Nuclear RNA-splicing-associated protein RRM_1 PF00076.22 CDI87221.1 - 0.1 12.4 0.0 0.32 10.8 0.0 1.9 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CDC27 PF09507.10 CDI87222.1 - 2.1 7.7 10.5 2.7 7.3 10.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SURF6 PF04935.12 CDI87222.1 - 2.2 8.0 11.2 3 7.6 11.2 1.2 1 0 0 1 1 1 0 Surfeit locus protein 6 DUF1690 PF07956.11 CDI87222.1 - 3.3 8.1 5.4 2.1 8.8 1.3 2.0 1 1 2 3 3 3 0 Protein of Unknown function (DUF1690) Myc_N PF01056.18 CDI87222.1 - 5.3 6.9 11.8 6.6 6.5 11.8 1.1 1 0 0 1 1 1 0 Myc amino-terminal region PRP38_assoc PF12871.7 CDI87224.1 - 1.6 9.4 82.1 1.6 9.4 54.6 2.8 1 1 1 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Trypan_PARP PF05887.11 CDI87224.1 - 2.6 8.0 20.6 0.1 12.6 13.5 2.0 1 1 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) MORN PF02493.20 CDI87226.1 - 9.8e-12 44.0 8.6 8.7e-08 31.6 2.5 3.7 3 0 0 3 3 3 3 MORN repeat LRR_9 PF14580.6 CDI87227.1 - 3.4e-18 65.7 0.2 5.4e-08 32.5 0.0 3.4 2 1 1 3 3 3 3 Leucine-rich repeat LRR_4 PF12799.7 CDI87227.1 - 5.5e-13 48.9 12.3 1.3e-06 28.6 1.1 5.2 2 2 5 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI87227.1 - 2e-09 37.1 8.8 0.0029 17.3 0.3 4.6 2 2 3 5 5 5 5 Leucine rich repeat LRR_6 PF13516.6 CDI87227.1 - 0.099 12.7 3.8 3.1 8.1 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich repeat TolA_bind_tri PF16331.5 CDI87228.1 - 0.0021 18.1 1.4 0.0021 18.1 1.4 10.1 6 2 2 9 9 9 2 TolA binding protein trimerisation PKcGMP_CC PF16808.5 CDI87228.1 - 0.096 12.6 0.2 0.096 12.6 0.2 4.7 6 0 0 6 6 6 0 Coiled-coil N-terminus of cGMP-dependent protein kinase EF-hand_1 PF00036.32 CDI87229.1 - 4.3e-17 60.3 1.5 2.7e-07 29.7 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 CDI87229.1 - 7.8e-17 59.7 4.5 2.2e-07 30.3 0.2 3.6 3 1 1 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 CDI87229.1 - 2.6e-16 59.8 0.7 9.2e-09 35.6 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 CDI87229.1 - 4.7e-12 46.1 0.0 4.3e-07 30.2 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 CDI87229.1 - 1.4e-09 37.0 0.7 8e-05 22.0 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDI87229.1 - 0.00011 21.9 3.0 0.0026 17.6 0.2 3.1 1 1 2 3 3 3 1 EF-hand domain pair EF-hand_14 PF17959.1 CDI87229.1 - 0.061 13.7 0.0 9.4 6.7 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain LNS2 PF08235.13 CDI87230.1 - 6.6e-94 313.6 0.0 9.1e-94 313.1 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 CDI87230.1 - 5.1e-29 100.2 0.0 8.8e-29 99.5 0.0 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 CDI87230.1 - 6.7e-20 71.1 0.0 1.3e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain DUF508 PF04370.12 CDI87230.1 - 7.2 6.3 8.6 25 4.6 8.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF508) Kinesin PF00225.23 CDI87232.1 - 3.9e-86 289.0 0.1 3.1e-74 249.9 0.1 2.7 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 CDI87232.1 - 1.1e-05 25.4 0.0 0.0054 16.7 0.0 2.7 2 0 0 2 2 2 2 Microtubule binding FlaC_arch PF05377.11 CDI87232.1 - 5.8 7.4 15.1 18 5.8 0.4 3.9 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Cgr1 PF03879.14 CDI87233.1 - 0.00066 20.0 22.6 0.0013 19.0 22.6 1.6 1 0 0 1 1 1 1 Cgr1 family DUF4578 PF15147.6 CDI87233.1 - 0.021 15.7 6.6 0.058 14.3 6.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4578) DUF4200 PF13863.6 CDI87234.1 - 2.7e-14 53.6 13.9 2.7e-14 53.6 13.9 3.8 3 1 0 3 3 3 2 Domain of unknown function (DUF4200) HWE_HK PF07536.14 CDI87234.1 - 0.028 15.1 0.3 0.028 15.1 0.3 2.2 2 0 0 2 2 2 0 HWE histidine kinase LIDHydrolase PF10230.9 CDI87234.1 - 0.64 9.5 4.1 0.2 11.2 1.1 1.7 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase DUF16 PF01519.16 CDI87234.1 - 3.3 8.3 32.4 0.16 12.5 1.2 4.3 3 2 2 5 5 5 0 Protein of unknown function DUF16 DUF948 PF06103.11 CDI87234.1 - 7.2 6.9 9.8 7 7.0 0.3 3.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Hormone_1 PF00103.20 CDI87234.1 - 9.8 5.9 12.0 1.9 8.2 0.5 3.2 3 0 0 3 3 3 0 Somatotropin hormone family ADK PF00406.22 CDI87235.1 - 4e-25 88.7 0.0 3.8e-14 53.0 0.0 2.6 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 CDI87235.1 - 2.2e-17 63.8 0.6 1.3e-10 41.8 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 CDI87235.1 - 9.1e-05 23.0 0.1 0.054 14.0 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 CDI87235.1 - 0.0095 16.1 9.7 0.066 13.4 0.1 3.6 2 1 0 3 3 3 2 AAA domain DUF5586 PF17824.1 CDI87235.1 - 0.034 13.3 0.1 0.034 13.3 0.1 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5586) Cytidylate_kin2 PF13189.6 CDI87235.1 - 0.044 13.9 0.1 2.1 8.4 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase-like family Spt20 PF12090.8 CDI87235.1 - 10 5.7 24.9 0.66 9.5 0.2 2.2 2 0 0 2 2 2 0 Spt20 family SR-25 PF10500.9 CDI87236.1 - 0.0014 18.2 23.4 0.0014 18.2 23.4 1.5 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI87236.1 - 0.0062 16.6 48.5 0.0089 16.1 48.5 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Auxin_canalis PF05703.11 CDI87236.1 - 0.018 15.0 13.4 0.026 14.5 13.4 1.2 1 0 0 1 1 1 0 Auxin canalisation K_channel_TID PF07941.11 CDI87236.1 - 0.056 13.9 1.9 0.056 13.9 1.9 4.1 4 1 0 4 4 3 0 Potassium channel Kv1.4 tandem inactivation domain GAGA_bind PF06217.12 CDI87236.1 - 0.15 12.3 22.9 0.22 11.8 22.9 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Asp-B-Hydro_N PF05279.11 CDI87236.1 - 0.79 9.7 31.9 0.91 9.5 31.9 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Draxin PF15550.6 CDI87236.1 - 2.1 8.1 22.6 3.1 7.6 22.6 1.3 1 0 0 1 1 1 0 Draxin CDC45 PF02724.14 CDI87236.1 - 2.6 6.2 31.9 3.5 5.8 31.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.6 CDI87236.1 - 2.7 7.5 27.7 3.6 7.1 27.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Dapper PF15268.6 CDI87236.1 - 3.1 6.6 33.5 3.6 6.3 33.5 1.0 1 0 0 1 1 1 0 Dapper DUF572 PF04502.13 CDI87236.1 - 3.8 7.0 31.7 4.8 6.7 31.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) PAT1 PF09770.9 CDI87236.1 - 7.3 4.7 38.8 8.9 4.4 38.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hamartin PF04388.12 CDI87236.1 - 8.9 4.8 30.6 11 4.5 30.6 1.0 1 0 0 1 1 1 0 Hamartin protein PRA1 PF03208.19 CDI87237.1 - 0.024 14.3 0.8 0.028 14.0 0.8 1.1 1 0 0 1 1 1 0 PRA1 family protein Spt20 PF12090.8 CDI87237.1 - 0.04 13.5 3.6 0.041 13.5 3.6 1.2 1 0 0 1 1 1 0 Spt20 family EF-hand_14 PF17959.1 CDI87237.1 - 0.059 13.7 0.2 0.09 13.1 0.2 1.2 1 0 0 1 1 1 0 EF-hand domain Phage_holin_3_3 PF16083.5 CDI87237.1 - 0.4 10.8 6.6 2.8 8.1 0.1 2.3 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III DUF1345 PF07077.11 CDI87237.1 - 0.4 10.4 8.4 0.49 10.1 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) Lipoprotein_2 PF00921.17 CDI87237.1 - 0.46 10.0 13.2 0.58 9.7 13.2 1.0 1 0 0 1 1 1 0 Borrelia lipoprotein ATP-synt_ab PF00006.25 CDI87237.1 - 0.77 9.4 5.0 0.85 9.2 5.0 1.0 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF2781 PF10914.8 CDI87237.1 - 1.8 9.0 6.9 0.63 10.4 0.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2781) DUF3138 PF11336.8 CDI87237.1 - 2.2 6.8 22.0 2.8 6.4 22.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF2339 PF10101.9 CDI87237.1 - 4.4 5.8 16.2 4.7 5.7 16.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) Conotoxin PF02950.17 CDI87238.1 - 0.08 14.0 0.4 0.08 14.0 0.4 7.2 2 1 1 3 3 3 0 Conotoxin DEAD PF00270.29 CDI87239.1 - 0.00085 19.1 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1387 PF07139.11 CDI87239.1 - 0.15 11.8 5.4 0.16 11.7 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DnaJ-X PF14308.6 CDI87240.1 - 2.8 7.3 9.0 4.6 6.6 9.0 1.3 1 0 0 1 1 1 0 X-domain of DnaJ-containing AAA_16 PF13191.6 CDI87241.1 - 2.3e-06 28.1 1.2 2.3e-06 28.1 1.2 3.4 3 0 0 3 3 3 1 AAA ATPase domain AAA_33 PF13671.6 CDI87241.1 - 0.0034 17.5 1.7 0.2 11.8 0.1 3.2 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 CDI87241.1 - 0.0072 16.8 0.0 0.021 15.4 0.0 1.8 1 0 0 1 1 1 1 ABC transporter Zeta_toxin PF06414.12 CDI87241.1 - 0.31 10.3 8.7 0.29 10.4 2.0 2.7 2 1 0 2 2 2 0 Zeta toxin Otopetrin PF03189.13 CDI87242.1 - 0.00029 19.8 2.1 0.00029 19.8 2.1 3.5 1 1 1 2 2 2 1 Otopetrin Spt20 PF12090.8 CDI87242.1 - 0.0017 18.0 24.3 0.0017 18.0 24.3 5.0 3 2 2 5 5 5 1 Spt20 family SDA1 PF05285.12 CDI87242.1 - 0.011 15.2 36.1 0.18 11.2 3.5 2.2 2 0 0 2 2 2 0 SDA1 Utp14 PF04615.13 CDI87242.1 - 1.1 7.7 54.9 0.016 13.8 22.7 2.0 2 0 0 2 2 2 0 Utp14 protein NAD_binding_1 PF00175.21 CDI87243.1 - 0.00043 20.9 0.0 0.00043 20.9 0.0 5.3 5 0 0 5 5 5 1 Oxidoreductase NAD-binding domain SDA1 PF05285.12 CDI87243.1 - 0.0042 16.6 20.8 0.0042 16.6 20.8 4.7 3 2 1 4 4 4 1 SDA1 RskA PF10099.9 CDI87243.1 - 0.0062 16.9 14.1 0.0062 16.9 14.1 12.5 4 1 7 12 12 12 1 Anti-sigma-K factor rskA PIP5K PF01504.18 CDI87243.1 - 0.01 15.1 0.6 0.01 15.1 0.6 4.2 2 1 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase MASE2 PF05230.11 CDI87243.1 - 3.4 7.8 7.2 0.65 10.1 0.9 3.3 2 0 0 2 2 2 0 MASE2 domain RskA PF10099.9 CDI87244.1 - 0.059 13.7 7.7 0.075 13.3 7.7 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA CAP_N PF01213.19 CDI87244.1 - 0.13 11.8 4.3 0.16 11.5 4.3 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DEC-1_N PF04625.13 CDI87244.1 - 0.21 10.5 8.2 0.24 10.4 8.2 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region SR-25 PF10500.9 CDI87245.1 - 0.00033 20.3 42.5 0.052 13.2 8.4 3.4 3 0 0 3 3 3 3 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI87245.1 - 0.00069 19.7 40.8 0.13 12.2 13.4 3.1 3 0 0 3 3 3 3 Transcription factor IIA, alpha/beta subunit DUF4667 PF15700.5 CDI87245.1 - 0.0017 18.5 23.5 0.016 15.3 1.5 3.4 3 0 0 3 3 3 3 Domain of unknown function (DUF4667) DUF4050 PF13259.6 CDI87245.1 - 0.28 11.5 19.1 1.3 9.3 1.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4050) DUF4614 PF15391.6 CDI87245.1 - 2.5 8.1 33.5 0.59 10.1 9.5 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4614) Phage_CRI PF05144.14 CDI87245.1 - 2.6 7.3 8.4 1 8.6 0.4 2.1 2 0 0 2 2 2 0 Phage replication protein CRI DUF3347 PF11827.8 CDI87245.1 - 3 8.0 11.4 12 6.0 4.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) Neur_chan_memb PF02932.16 CDI87245.1 - 5.4 7.0 11.7 4.3 7.3 0.1 3.1 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI87245.1 - 9.5 4.9 22.9 1 8.0 0.8 3.1 3 0 0 3 3 3 0 Presenilin DUF445 PF04286.12 CDI87246.1 - 0.34 10.7 11.8 0.041 13.7 3.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF445) MCD PF05292.11 CDI87246.1 - 1.6 8.2 15.4 0.97 9.0 2.6 2.4 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase C-terminal domain DUF5092 PF17010.5 CDI87246.1 - 4.1 7.3 5.1 1.2 9.0 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5092) RskA PF10099.9 CDI87247.1 - 1.6e-06 28.5 15.9 6.6e-05 23.3 11.6 2.2 1 1 1 2 2 2 2 Anti-sigma-K factor rskA TraT PF05818.12 CDI87247.1 - 0.00093 18.9 6.4 0.00093 18.9 6.4 2.2 2 0 0 2 2 2 1 Enterobacterial TraT complement resistance protein SpoIIP PF07454.11 CDI87247.1 - 0.033 13.6 15.8 0.07 12.6 6.7 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) RPA43_OB PF17875.1 CDI87247.1 - 0.097 13.3 9.1 0.38 11.4 4.1 2.2 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I His_Phos_1 PF00300.22 CDI87247.1 - 0.15 11.8 20.1 0.25 11.0 9.3 2.8 2 1 1 3 3 2 0 Histidine phosphatase superfamily (branch 1) SprA-related PF12118.8 CDI87247.1 - 0.36 9.9 33.9 0.0097 15.1 17.1 2.2 2 0 0 2 2 2 0 SprA-related family DUF4628 PF15429.6 CDI87247.1 - 0.44 10.2 13.6 0.17 11.5 4.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4628) DUF1980 PF09323.10 CDI87247.1 - 0.55 10.1 9.1 0.3 11.0 2.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Eapp_C PF10238.9 CDI87247.1 - 0.67 10.0 16.0 2.8 8.0 0.6 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein Folliculin PF11704.8 CDI87247.1 - 0.99 9.3 14.5 2.6 7.9 6.7 2.5 3 0 0 3 3 3 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF702 PF05142.12 CDI87247.1 - 1 9.8 18.4 2.8 8.4 8.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF702) RR_TM4-6 PF06459.12 CDI87247.1 - 1.2 8.8 14.3 2.1 8.1 7.4 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 G0-G1_switch_2 PF15103.6 CDI87247.1 - 1.3 9.4 14.2 1.3 9.5 5.6 2.5 2 0 0 2 2 2 0 G0/G1 switch protein 2 CPSF100_C PF13299.6 CDI87247.1 - 1.5 9.0 13.4 1.1 9.4 5.2 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal YABBY PF04690.13 CDI87247.1 - 1.7 9.2 13.6 0.17 12.5 3.4 2.2 2 0 0 2 2 2 0 YABBY protein Folate_carrier PF01770.18 CDI87247.1 - 1.9 7.1 8.8 1.8 7.2 2.9 2.2 2 0 0 2 2 2 0 Reduced folate carrier MRP-S26 PF14943.6 CDI87247.1 - 2.2 8.2 21.2 3.7 7.4 9.3 2.4 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 FlaG PF03646.15 CDI87247.1 - 3.5 7.9 31.3 1.3 9.2 17.0 2.4 2 0 0 2 2 2 0 FlaG protein DUF4578 PF15147.6 CDI87247.1 - 4.1 8.3 24.1 10 7.0 4.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) GNAT_acetyltr_2 PF13718.6 CDI87247.1 - 4.6 6.6 15.8 2.3 7.6 5.8 2.2 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Rxt3 PF08642.10 CDI87247.1 - 5.6 7.8 10.8 8.2 7.2 4.0 2.3 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 AIF_C PF14721.6 CDI87247.1 - 5.7 7.3 12.5 5.3 7.4 5.6 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term PAT1 PF09770.9 CDI87247.1 - 6.5 4.9 34.7 8.8 4.5 34.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CSG2 PF16965.5 CDI87247.1 - 7.1 5.5 9.6 2.2 7.1 3.7 2.0 2 0 0 2 2 2 0 Ceramide synthase regulator EFTUD2 PF16004.5 CDI87247.1 - 7.3 7.2 18.6 9.5 6.8 10.0 2.3 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus FCP1_C PF09309.10 CDI87247.1 - 8.6 6.2 17.8 0.11 12.4 5.6 2.1 2 0 0 2 2 2 0 FCP1, C-terminal DUF3371 PF11851.8 CDI87247.1 - 9.4 7.4 23.8 3.6 8.7 9.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) BRF1 PF07741.13 CDI87247.1 - 9.6 6.6 18.6 1.5 9.2 5.9 2.7 2 0 0 2 2 2 0 Brf1-like TBP-binding domain SR-25 PF10500.9 CDI87250.1 - 0.00043 20.0 6.2 0.00079 19.1 3.0 2.2 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein FHIPEP PF00771.20 CDI87250.1 - 0.011 14.3 6.3 0.013 14.0 6.3 1.2 1 0 0 1 1 1 0 FHIPEP family DUF3446 PF11928.8 CDI87250.1 - 0.35 11.2 10.6 2.4 8.5 6.5 2.8 3 0 0 3 3 3 0 Early growth response N-terminal domain IMUP PF15761.5 CDI87250.1 - 0.82 10.4 15.6 0.093 13.4 5.1 2.6 3 0 0 3 3 3 0 Immortalisation up-regulated protein PA26 PF04636.13 CDI87250.1 - 1.3 7.8 6.6 0.89 8.4 5.0 1.5 1 1 0 1 1 1 0 PA26 p53-induced protein (sestrin) Lin-8 PF03353.15 CDI87250.1 - 1.5 8.3 17.4 0.41 10.2 11.7 2.0 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF1635 PF07795.11 CDI87250.1 - 1.6 8.5 15.9 8.4 6.2 10.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) PepSY_TM PF03929.16 CDI87250.1 - 7.3 6.2 7.7 0.82 9.3 2.8 1.6 1 1 1 2 2 2 0 PepSY-associated TM region TFIIA PF03153.13 CDI87251.1 - 0.14 12.2 7.1 0.16 11.9 7.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Plasmodium_HRP PF05403.11 CDI87251.1 - 2.6 7.8 11.5 26 4.5 11.5 2.2 1 1 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) Spt20 PF12090.8 CDI87251.1 - 3.7 7.1 8.8 5.8 6.4 8.8 1.2 1 0 0 1 1 1 0 Spt20 family Med3 PF11593.8 CDI87251.1 - 9.5 5.3 9.1 15 4.6 9.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal RR_TM4-6 PF06459.12 CDI87253.1 - 0.79 9.5 19.4 0.93 9.3 19.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 IHABP4_N PF16174.5 CDI87253.1 - 0.91 10.1 26.2 1.1 9.9 26.2 1.0 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Rgp1 PF08737.10 CDI87253.1 - 1.5 7.9 13.2 1.7 7.8 13.2 1.0 1 0 0 1 1 1 0 Rgp1 Lin-8 PF03353.15 CDI87253.1 - 1.9 8.0 19.8 2.1 7.8 19.8 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist FAM60A PF15396.6 CDI87253.1 - 2.1 8.3 11.5 2.6 8.0 11.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A VIR_N PF15912.5 CDI87253.1 - 4.7 6.7 12.9 5.2 6.6 12.9 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal LMBR1 PF04791.16 CDI87253.1 - 4.8 6.0 8.2 5.2 5.8 8.2 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Hid1 PF12722.7 CDI87253.1 - 5 5.1 15.3 5.3 5.0 15.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CDI87253.1 - 5.2 5.7 21.9 6 5.5 21.9 1.0 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 CDI87253.1 - 5.3 5.9 11.9 5.9 5.8 11.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RCR PF12273.8 CDI87253.1 - 7 7.3 14.6 8.3 7.1 14.6 1.2 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red SLC12 PF03522.15 CDI87253.1 - 9.1 5.2 18.1 9.5 5.1 18.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI87253.1 - 9.1 4.4 25.3 9.7 4.3 25.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hydin_ADK PF17213.3 CDI87253.1 - 9.6 6.4 17.3 12 6.2 17.3 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Ndc1_Nup PF09531.10 CDI87253.1 - 9.7 4.7 12.6 11 4.6 12.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GREB1 PF15782.5 CDI87254.1 - 0.12 9.5 43.3 0.14 9.3 43.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Draxin PF15550.6 CDI87254.1 - 0.12 12.2 36.5 0.14 12.0 36.5 1.1 1 0 0 1 1 1 0 Draxin Ribosomal_60s PF00428.19 CDI87254.1 - 0.13 12.9 9.7 0.35 11.5 9.7 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein SOBP PF15279.6 CDI87254.1 - 1.2 9.7 42.7 1.6 9.3 42.7 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Caldesmon PF02029.15 CDI87254.1 - 2.8 6.6 49.1 3.4 6.3 49.1 1.0 1 0 0 1 1 1 0 Caldesmon PAT1 PF09770.9 CDI87254.1 - 3.1 6.0 73.3 4.4 5.4 73.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 CDI87254.1 - 4.4 6.2 48.9 5.9 5.8 48.9 1.3 1 0 0 1 1 1 0 Solute carrier family 12 SR-25 PF10500.9 CDI87255.1 - 0.00037 20.2 13.5 0.00037 20.2 13.5 4.2 4 1 0 4 4 4 2 Nuclear RNA-splicing-associated protein DUF1645 PF07816.11 CDI87255.1 - 0.0041 17.7 4.5 0.0041 17.7 4.5 4.1 2 1 1 3 3 3 1 Protein of unknown function (DUF1645) V_ATPase_I PF01496.19 CDI87255.1 - 0.46 8.3 41.1 0.0071 14.3 21.5 3.1 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family DUF726 PF05277.12 CDI87255.1 - 6.2 5.6 7.0 3.3 6.5 4.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF726) DUF1345 PF07077.11 CDI87255.1 - 8 6.1 16.4 6.6 6.4 0.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1345) Methyltr_RsmB-F PF01189.17 CDI87256.1 - 4.7e-06 26.4 0.0 4.7e-06 26.4 0.0 3.6 1 1 2 3 3 3 1 16S rRNA methyltransferase RsmB/F Caldesmon PF02029.15 CDI87256.1 - 0.031 13.1 46.0 0.046 12.5 46.0 1.4 1 0 0 1 1 1 0 Caldesmon Utp14 PF04615.13 CDI87256.1 - 0.12 11.0 51.5 0.15 10.6 51.5 1.1 1 0 0 1 1 1 0 Utp14 protein Hamartin PF04388.12 CDI87256.1 - 5.5 5.5 56.7 7 5.2 56.7 1.0 1 0 0 1 1 1 0 Hamartin protein SUIM_assoc PF16619.5 CDI87257.1 - 0.0048 16.9 0.4 0.0048 16.9 0.4 4.6 4 1 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 DUF4726 PF15855.5 CDI87257.1 - 0.022 15.0 0.5 0.022 15.0 0.5 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4726) Importin_rep_6 PF18829.1 CDI87257.1 - 0.039 14.1 0.2 0.087 13.0 0.2 1.6 1 0 0 1 1 1 0 Importin repeat 6 DUF3100 PF11299.8 CDI87257.1 - 0.19 11.1 1.8 0.24 10.8 0.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3100) PEX11 PF05648.14 CDI87257.1 - 1.9 7.9 6.6 0.6 9.5 0.7 2.3 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) RskA PF10099.9 CDI87257.1 - 8.9 6.6 36.4 0.95 9.7 5.5 3.1 1 1 0 2 2 2 0 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI87258.1 - 1.8e-05 24.5 69.2 0.0031 17.2 20.4 3.9 4 0 0 4 4 4 3 Spt20 family DUF2722 PF10846.8 CDI87258.1 - 0.0074 15.3 15.7 0.0074 15.3 15.7 3.8 3 1 1 4 4 4 2 Protein of unknown function (DUF2722) DUF755 PF05501.11 CDI87258.1 - 2.5 8.4 47.7 0.54 10.5 14.8 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF755) Apt1 PF10351.9 CDI87258.1 - 3.6 6.3 27.3 0.24 10.2 1.8 3.1 3 0 0 3 3 3 0 Golgi-body localisation protein domain Roughex PF06020.11 CDI87258.1 - 4.5 6.3 40.0 1.1 8.3 10.4 3.7 3 0 0 3 3 3 0 Drosophila roughex protein RskA PF10099.9 CDI87259.1 - 3.1e-06 27.6 9.4 3.1e-06 27.6 9.4 6.1 1 1 3 4 4 4 1 Anti-sigma-K factor rskA TMEM51 PF15345.6 CDI87259.1 - 6e-05 23.0 12.8 6e-05 23.0 12.8 7.2 3 2 0 3 3 3 1 Transmembrane protein 51 TCP PF03634.13 CDI87259.1 - 0.016 15.8 12.9 0.016 15.8 12.9 5.3 3 2 1 4 4 4 0 TCP family transcription factor MscS_TM PF12794.7 CDI87260.1 - 0.84 8.4 1.6 0.81 8.5 1.6 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Roughex PF06020.11 CDI87260.1 - 2.6 7.0 15.0 4.1 6.4 15.0 1.3 1 0 0 1 1 1 0 Drosophila roughex protein SPX PF03105.19 CDI87260.1 - 7.3 6.4 22.8 8.2 6.2 22.8 1.0 1 0 0 1 1 1 0 SPX domain DUF4175 PF13779.6 CDI87260.1 - 7.5 4.3 14.4 7.6 4.3 14.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) WD40 PF00400.32 CDI87262.1 - 2.1e-30 104.3 23.8 0.00019 22.2 1.6 10.7 12 0 0 12 12 12 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI87262.1 - 5.5e-14 52.2 0.0 0.076 13.3 0.0 7.2 4 3 4 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDI87262.1 - 5.5e-06 25.6 0.1 0.011 14.7 0.0 4.1 5 0 0 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 CDI87262.1 - 0.00021 21.0 0.0 0.066 12.8 0.0 2.9 2 1 2 4 4 4 2 PQQ-like domain eIF2A PF08662.11 CDI87262.1 - 0.00034 20.5 0.0 0.015 15.2 0.0 3.1 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A PQQ_3 PF13570.6 CDI87262.1 - 0.0025 18.2 6.9 22 5.7 0.0 7.0 8 1 0 8 8 8 0 PQQ-like domain Nup160 PF11715.8 CDI87262.1 - 0.043 12.5 0.1 6.5 5.3 0.1 2.8 2 1 0 2 2 2 0 Nucleoporin Nup120/160 PD40 PF07676.12 CDI87262.1 - 0.057 13.4 0.0 1.3e+02 2.7 0.0 4.3 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat EzrA PF06160.12 CDI87263.1 - 4.3e-05 21.9 9.9 4.3e-05 21.9 9.9 2.3 2 1 0 1 1 1 1 Septation ring formation regulator, EzrA Baculo_PEP_C PF04513.12 CDI87263.1 - 0.0017 18.4 7.9 0.019 15.0 0.4 3.5 2 1 0 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus ATG16 PF08614.11 CDI87263.1 - 0.0035 17.6 18.9 0.0035 17.6 18.9 3.6 2 2 0 2 2 1 1 Autophagy protein 16 (ATG16) BLOC1_2 PF10046.9 CDI87263.1 - 0.0036 17.6 23.1 0.18 12.1 0.3 5.5 2 2 3 5 5 5 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 GAS PF13851.6 CDI87263.1 - 0.0062 15.9 13.2 0.0062 15.9 13.2 4.1 2 2 0 3 3 3 1 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 CDI87263.1 - 0.14 12.6 28.4 0.14 12.6 5.6 3.2 2 1 0 2 2 2 0 Fez1 IFT57 PF10498.9 CDI87263.1 - 0.15 11.0 20.8 0.16 10.9 6.9 3.5 1 1 3 4 4 4 0 Intra-flagellar transport protein 57 DUF1664 PF07889.12 CDI87263.1 - 0.18 11.9 20.5 0.12 12.4 5.9 4.5 2 2 3 5 5 5 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 CDI87263.1 - 0.63 10.1 18.7 0.06 13.4 5.1 3.9 2 2 2 4 4 4 0 Laminin Domain II NuiA PF07924.11 CDI87263.1 - 0.98 9.8 3.8 2.2 8.7 1.6 2.6 2 1 1 3 3 2 0 Nuclease A inhibitor-like protein Spc7 PF08317.11 CDI87263.1 - 1.2 7.9 31.9 0.012 14.5 11.0 3.4 2 1 1 3 3 3 0 Spc7 kinetochore protein TetR PF13972.6 CDI87263.1 - 1.2 8.8 10.7 0.12 12.1 1.0 3.1 2 2 0 2 2 2 0 Bacterial transcriptional repressor Cauli_AT PF03233.13 CDI87263.1 - 3.5 7.5 12.2 0.27 11.2 3.9 2.7 2 1 0 3 3 3 0 Aphid transmission protein FlaC_arch PF05377.11 CDI87263.1 - 3.9 7.9 12.3 33 5.0 0.2 5.1 3 2 2 6 6 6 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.10 CDI87263.1 - 4.4 7.5 18.9 1.9 8.7 9.4 3.6 2 2 2 4 4 4 0 Fibrinogen alpha/beta chain family Cor1 PF04803.12 CDI87263.1 - 6 7.1 15.9 1.2 9.3 11.5 2.2 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region Noelin-1 PF12308.8 CDI87263.1 - 6.7 6.8 11.3 25 4.9 3.6 3.6 2 2 0 3 3 3 0 Neurogenesis glycoprotein DUF724 PF05266.14 CDI87263.1 - 7 6.4 28.4 4.9 6.9 9.1 4.0 2 2 2 4 4 4 0 Protein of unknown function (DUF724) Glyco_hydro_77 PF02446.17 CDI87264.1 - 4.1e-116 388.6 2.6 1.3e-93 314.4 2.5 2.8 2 1 0 2 2 2 2 4-alpha-glucanotransferase Ant_C PF05586.11 CDI87265.1 - 0.0021 18.6 1.1 0.0025 18.4 1.1 1.1 1 0 0 1 1 1 1 Anthrax receptor C-terminus region DUF3292 PF11696.8 CDI87265.1 - 0.059 11.7 3.7 0.067 11.6 3.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Presenilin PF01080.17 CDI87265.1 - 2.1 7.0 3.7 2.2 7.0 3.7 1.0 1 0 0 1 1 1 0 Presenilin ING PF12998.7 CDI87266.1 - 0.97 10.1 6.5 3 8.5 0.1 3.2 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding DUF1917 PF08939.10 CDI87266.1 - 1.8 8.4 9.0 0.14 12.1 3.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1917) BAF1_ABF1 PF04684.13 CDI87267.1 - 0.0011 18.2 23.6 0.0012 18.0 23.6 1.1 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor BSP_II PF05432.11 CDI87267.1 - 0.042 13.5 14.3 0.05 13.3 14.3 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) SMYLE_N PF18615.1 CDI87267.1 - 0.068 12.7 12.9 0.077 12.5 12.9 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain FAM60A PF15396.6 CDI87267.1 - 0.16 12.0 18.7 0.21 11.6 18.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Peptidase_S64 PF08192.11 CDI87267.1 - 0.22 10.0 13.3 0.25 9.8 13.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 CDC27 PF09507.10 CDI87267.1 - 0.22 10.9 30.3 0.24 10.7 30.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SAGA-Tad1 PF12767.7 CDI87267.1 - 0.24 11.1 18.8 0.3 10.8 18.8 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit RR_TM4-6 PF06459.12 CDI87267.1 - 0.34 10.7 23.5 0.44 10.3 23.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PPP4R2 PF09184.11 CDI87267.1 - 0.37 10.4 14.2 0.47 10.0 14.2 1.2 1 0 0 1 1 1 0 PPP4R2 DUF572 PF04502.13 CDI87267.1 - 0.39 10.3 18.0 0.45 10.1 18.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) LAP1C PF05609.12 CDI87267.1 - 0.51 9.4 22.0 0.55 9.3 22.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) eIF-3c_N PF05470.12 CDI87267.1 - 0.54 8.5 14.1 0.67 8.2 14.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Presenilin PF01080.17 CDI87267.1 - 0.71 8.6 30.6 0.87 8.3 30.6 1.1 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 CDI87267.1 - 0.8 7.7 22.5 0.87 7.6 22.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Rgp1 PF08737.10 CDI87267.1 - 0.89 8.7 15.2 0.96 8.6 15.2 1.0 1 0 0 1 1 1 0 Rgp1 DUF1387 PF07139.11 CDI87267.1 - 0.98 9.1 18.7 1.3 8.7 18.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) ASD2 PF08687.11 CDI87267.1 - 1.2 8.6 23.7 1.6 8.2 23.7 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Hamartin PF04388.12 CDI87267.1 - 1.3 7.6 21.2 1.6 7.3 21.2 1.0 1 0 0 1 1 1 0 Hamartin protein SURF2 PF05477.11 CDI87267.1 - 1.4 8.5 19.7 1.9 8.1 19.7 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) VIR_N PF15912.5 CDI87267.1 - 2 7.9 16.1 2.6 7.6 16.1 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal SARAF PF06682.12 CDI87267.1 - 2.3 7.8 23.1 3.1 7.4 23.1 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis GREB1 PF15782.5 CDI87267.1 - 2.3 5.2 22.1 2.4 5.2 22.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Apt1 PF10351.9 CDI87267.1 - 2.6 6.8 13.7 2.9 6.6 13.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4551 PF15087.6 CDI87267.1 - 3.2 6.5 15.2 3.4 6.4 15.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SWI-SNF_Ssr4 PF08549.10 CDI87267.1 - 3.6 6.1 36.6 4.2 5.9 36.6 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF908 PF06012.12 CDI87267.1 - 3.7 6.9 15.7 4.3 6.7 15.7 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Asp-B-Hydro_N PF05279.11 CDI87267.1 - 4.2 7.4 21.0 5 7.1 21.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Zip PF02535.22 CDI87267.1 - 4.6 6.4 14.1 6.3 5.9 14.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Nop53 PF07767.11 CDI87267.1 - 4.7 6.5 31.8 5.9 6.2 31.8 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PAT1 PF09770.9 CDI87267.1 - 6.1 5.0 38.9 7.8 4.6 38.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MRP-S26 PF14943.6 CDI87267.1 - 6.9 6.6 29.4 9.7 6.1 29.4 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 DUF966 PF06136.13 CDI87267.1 - 6.9 6.3 19.8 7.5 6.2 19.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) PNISR PF15996.5 CDI87267.1 - 6.9 6.9 32.5 9.9 6.4 32.5 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Peroxin-3 PF04882.12 CDI87267.1 - 7.2 5.5 24.7 9.4 5.1 24.7 1.4 1 0 0 1 1 1 0 Peroxin-3 CDC45 PF02724.14 CDI87267.1 - 7.4 4.7 25.1 9.3 4.4 25.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Smg8_Smg9 PF10220.9 CDI87267.1 - 9.4 4.4 23.8 11 4.2 23.8 1.0 1 0 0 1 1 1 0 Smg8_Smg9 SLC12 PF03522.15 CDI87267.1 - 9.8 5.1 26.2 12 4.7 26.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SKA1 PF07160.12 CDI87269.1 - 0.0044 16.9 25.4 0.0056 16.6 25.4 1.3 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 YabA PF06156.13 CDI87269.1 - 0.0095 16.6 12.6 0.0095 16.6 12.6 2.2 1 1 1 2 2 1 1 Initiation control protein YabA Presenilin PF01080.17 CDI87269.1 - 0.033 13.0 27.7 0.038 12.8 27.7 1.2 1 0 0 1 1 1 0 Presenilin SUIM_assoc PF16619.5 CDI87269.1 - 0.048 13.7 12.8 0.048 13.7 12.8 5.6 2 1 3 5 5 2 0 Unstructured region C-term to UIM in Ataxin3 AAA_11 PF13086.6 CDI87269.1 - 0.054 13.3 22.6 0.076 12.8 22.6 1.2 1 0 0 1 1 1 0 AAA domain Paf1 PF03985.13 CDI87269.1 - 0.23 10.4 23.2 0.29 10.1 23.2 1.1 1 0 0 1 1 1 0 Paf1 GREB1 PF15782.5 CDI87269.1 - 0.33 8.0 30.2 0.38 7.8 30.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Endostatin PF06482.11 CDI87269.1 - 0.57 9.6 18.5 0.69 9.3 18.5 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SLC12 PF03522.15 CDI87269.1 - 0.68 8.9 23.4 0.78 8.7 23.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CCDC84 PF14968.6 CDI87269.1 - 0.69 9.5 21.4 0.79 9.3 21.4 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 Neur_chan_memb PF02932.16 CDI87269.1 - 0.71 9.9 18.6 0.93 9.5 18.6 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Golgin_A5 PF09787.9 CDI87269.1 - 0.79 9.1 38.0 1.2 8.5 38.0 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF4746 PF15928.5 CDI87269.1 - 0.85 9.0 15.3 1.1 8.6 15.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) ALMT PF11744.8 CDI87269.1 - 0.98 8.2 22.0 1.2 7.9 22.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter VIR_N PF15912.5 CDI87269.1 - 1.1 8.8 15.6 1.4 8.4 15.6 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Hamartin PF04388.12 CDI87269.1 - 1.7 7.2 21.2 2 7.0 21.2 1.2 1 0 0 1 1 1 0 Hamartin protein Activator_LAG-3 PF11498.8 CDI87269.1 - 1.9 7.4 69.8 2.3 7.1 69.8 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 GAGA_bind PF06217.12 CDI87269.1 - 3.4 7.9 20.2 4 7.6 20.2 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family PAT1 PF09770.9 CDI87269.1 - 3.4 5.8 44.9 4 5.6 44.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 eIF-3_zeta PF05091.12 CDI87269.1 - 3.9 6.4 23.9 6.1 5.7 23.9 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4045 PF13254.6 CDI87269.1 - 4.6 6.8 28.1 5.7 6.5 28.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Asp-B-Hydro_N PF05279.11 CDI87269.1 - 5.1 7.1 23.8 6 6.9 23.8 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region LAP1C PF05609.12 CDI87269.1 - 5.4 6.0 28.5 6.5 5.7 28.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) XRN_M PF17846.1 CDI87269.1 - 7.2 5.5 17.4 8.1 5.3 17.4 1.2 1 0 0 1 1 1 0 Xrn1 helical domain SUIM_assoc PF16619.5 CDI87270.1 - 0.017 15.2 6.0 0.017 15.2 6.0 5.1 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 zf-CCCH_4 PF18044.1 CDI87270.1 - 3 7.8 7.6 9 6.2 7.6 1.7 1 1 0 1 1 1 0 CCCH-type zinc finger PPP4R2 PF09184.11 CDI87270.1 - 4.9 6.7 21.7 0.41 10.2 10.7 2.1 2 0 0 2 2 2 0 PPP4R2 VIR_N PF15912.5 CDI87270.1 - 6.7 6.2 14.2 15 5.1 14.2 1.5 1 0 0 1 1 1 0 Virilizer, N-terminal Lin-8 PF03353.15 CDI87271.1 - 0.55 9.7 14.9 0.84 9.1 14.9 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SPX PF03105.19 CDI87271.1 - 0.87 9.4 18.9 1.2 9.0 18.9 1.2 1 0 0 1 1 1 0 SPX domain SEEEED PF14797.6 CDI87271.1 - 4.4 7.5 27.9 4 7.6 26.6 1.6 1 1 1 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex TFIIA PF03153.13 CDI87271.1 - 6.5 6.6 28.5 8.3 6.3 28.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Draxin PF15550.6 CDI87271.1 - 8.1 6.2 10.6 11 5.7 10.6 1.1 1 0 0 1 1 1 0 Draxin Miff PF05644.11 CDI87271.1 - 8.9 5.8 15.9 11 5.5 15.9 1.1 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff SARAF PF06682.12 CDI87274.1 - 0.00019 21.2 26.6 0.00027 20.7 26.6 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Lin-8 PF03353.15 CDI87274.1 - 0.00088 18.9 23.4 0.0011 18.6 23.4 1.1 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 CDI87274.1 - 0.0014 17.0 14.4 0.0017 16.8 14.4 1.0 1 0 0 1 1 1 1 CDC45-like protein SR-25 PF10500.9 CDI87274.1 - 0.024 14.3 23.3 0.16 11.5 7.7 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Apt1 PF10351.9 CDI87274.1 - 0.032 13.1 15.6 0.039 12.8 15.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain PAT1 PF09770.9 CDI87274.1 - 0.056 11.7 32.7 0.066 11.5 32.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ribosomal_60s PF00428.19 CDI87274.1 - 0.065 13.8 25.5 0.27 11.9 5.8 2.7 3 0 0 3 3 2 0 60s Acidic ribosomal protein DUF572 PF04502.13 CDI87274.1 - 0.066 12.8 19.9 0.088 12.4 19.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Peptidase_S64 PF08192.11 CDI87274.1 - 0.071 11.6 19.9 0.085 11.3 19.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 SPX PF03105.19 CDI87274.1 - 0.092 12.6 21.7 0.12 12.3 21.7 1.1 1 0 0 1 1 1 0 SPX domain Dicty_REP PF05086.12 CDI87274.1 - 0.098 10.6 16.4 0.12 10.3 16.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein GREB1 PF15782.5 CDI87274.1 - 0.15 9.2 24.2 0.18 8.9 24.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4551 PF15087.6 CDI87274.1 - 0.4 9.5 13.1 0.51 9.1 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Hamartin PF04388.12 CDI87274.1 - 0.64 8.6 17.0 0.83 8.2 17.0 1.2 1 0 0 1 1 1 0 Hamartin protein cwf18 PF08315.12 CDI87274.1 - 0.68 10.6 19.8 29 5.3 18.9 2.1 2 0 0 2 2 2 0 cwf18 pre-mRNA splicing factor SAPS PF04499.15 CDI87274.1 - 1 8.1 15.2 1.4 7.6 15.2 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Cwf_Cwc_15 PF04889.12 CDI87274.1 - 1.3 8.7 22.3 2.1 8.0 22.3 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2828 PF11443.8 CDI87274.1 - 1.9 6.5 14.6 2.3 6.2 14.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) XRN_M PF17846.1 CDI87274.1 - 2.8 6.8 13.7 3.7 6.4 13.7 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Hid1 PF12722.7 CDI87274.1 - 3.1 5.8 24.0 3.9 5.5 24.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GET2 PF08690.10 CDI87274.1 - 3.3 7.3 24.7 4.5 6.9 24.7 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Cellulose_synt PF03552.14 CDI87274.1 - 3.8 5.9 4.8 4.1 5.8 4.8 1.1 1 0 0 1 1 1 0 Cellulose synthase Peptidase_U57 PF05582.12 CDI87274.1 - 4.8 6.4 11.6 8.8 5.5 11.6 1.4 1 0 0 1 1 1 0 YabG peptidase U57 Shadoo PF14999.6 CDI87274.1 - 5.1 7.2 21.4 0.56 10.3 0.2 2.5 2 1 0 2 2 2 0 Shadow of prion protein, neuroprotective Peptidase_S49_N PF08496.10 CDI87274.1 - 6.5 6.8 15.7 14 5.7 14.6 1.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal UPF0564 PF10595.9 CDI87274.1 - 7.7 5.5 34.1 1.8 7.5 31.1 1.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0564 Tetraspanin PF00335.20 CDI87275.1 - 0.26 11.0 5.0 2.8 7.6 5.0 2.7 1 1 0 1 1 1 0 Tetraspanin family Seryl_tRNA_N PF02403.22 CDI87276.1 - 2.4e-20 72.8 1.6 2.4e-20 72.8 1.6 3.1 3 0 0 3 3 3 1 Seryl-tRNA synthetase N-terminal domain MalM PF07148.12 CDI87276.1 - 0.018 14.8 1.9 0.018 14.8 1.9 1.7 2 0 0 2 2 2 0 Maltose operon periplasmic protein precursor (MalM) Spt20 PF12090.8 CDI87276.1 - 0.02 14.5 48.6 0.4 10.2 22.5 2.3 2 0 0 2 2 2 0 Spt20 family DUF2828 PF11443.8 CDI87276.1 - 0.055 11.6 5.6 0.095 10.8 5.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CLN3 PF02487.17 CDI87276.1 - 4.7 6.1 6.8 9 5.2 0.1 2.2 2 0 0 2 2 2 0 CLN3 protein RAP1 PF07218.11 CDI87277.1 - 5.2e-05 21.8 24.2 7.2e-05 21.3 24.2 1.2 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) Macoilin PF09726.9 CDI87277.1 - 0.19 10.3 70.1 0.0035 16.0 57.6 2.3 2 0 0 2 2 2 0 Macoilin family Caldesmon PF02029.15 CDI87278.1 - 0.0023 16.8 13.7 0.0023 16.8 13.7 2.2 2 0 0 2 2 2 2 Caldesmon DUF2722 PF10846.8 CDI87278.1 - 0.0024 16.9 15.4 0.0024 16.9 15.4 6.0 3 1 2 5 5 5 2 Protein of unknown function (DUF2722) Filament_head PF04732.14 CDI87278.1 - 0.5 11.3 19.1 0.31 11.9 9.4 2.7 2 0 0 2 2 2 0 Intermediate filament head (DNA binding) region TRA-1_regulated PF02343.16 CDI87280.1 - 0.035 14.1 0.2 0.035 14.1 0.2 2.6 3 0 0 3 3 3 0 TRA-1 regulated protein R03H10.4 FeoB_associated PF12669.7 CDI87280.1 - 0.13 12.7 3.2 0.4 11.1 3.2 1.8 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein ETRAMP PF09716.10 CDI87280.1 - 0.2 11.8 3.4 0.49 10.5 2.0 2.2 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF2076 PF09849.9 CDI87280.1 - 1 9.4 47.5 0.23 11.5 12.0 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2076) Orf78 PF06024.12 CDI87280.1 - 3.4 8.0 17.6 0.062 13.6 3.9 3.2 3 1 1 4 4 4 0 Orf78 (ac78) PDGF_N PF04692.13 CDI87280.1 - 6.2 7.7 21.0 1.6 9.6 1.7 4.0 4 0 0 4 4 4 0 Platelet-derived growth factor, N terminal region eIF-4B PF06273.11 CDI87280.1 - 8.5 5.3 15.9 0.65 9.0 1.8 2.6 2 1 1 3 3 3 0 Plant specific eukaryotic initiation factor 4B Ribo_biogen_C PF04034.13 CDI87282.1 - 2.3e-25 88.8 0.0 9.4e-25 86.8 0.0 1.8 2 0 0 2 2 2 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 CDI87282.1 - 0.00024 20.9 0.0 0.00045 20.0 0.0 1.5 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI DUF755 PF05501.11 CDI87284.1 - 0.00037 20.8 25.5 0.00037 20.8 25.5 14.8 14 1 1 15 15 15 3 Domain of unknown function (DUF755) WBP-1 PF11669.8 CDI87284.1 - 0.24 12.1 0.0 0.24 12.1 0.0 8.6 8 2 1 9 9 9 0 WW domain-binding protein 1 Chorion_2 PF03964.15 CDI87285.1 - 0.026 15.4 9.3 0.82 10.5 0.8 2.1 2 0 0 2 2 2 0 Chorion family 2 Ribosomal_60s PF00428.19 CDI87285.1 - 0.16 12.6 25.9 0.15 12.6 6.9 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3824 PF12868.7 CDI87285.1 - 5.9 7.5 21.6 0.074 13.7 8.7 2.2 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Penicil_amidase PF01804.18 CDI87287.1 - 1.4e-114 384.5 0.0 5.5e-107 359.4 0.0 2.0 1 1 1 2 2 2 2 Penicillin amidase DUF667 PF05018.13 CDI87288.1 - 6.2e-43 146.7 0.0 1.3e-42 145.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF667) LepA_C PF06421.12 CDI87288.1 - 6.9e-42 142.0 0.3 1.5e-41 140.8 0.3 1.6 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus GTP_EFTU PF00009.27 CDI87288.1 - 7.6e-10 38.7 0.0 1.5e-06 27.9 0.0 2.3 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain EFG_C PF00679.24 CDI87288.1 - 0.0021 18.0 0.0 0.0047 16.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus Phage_HK97_TLTM PF06120.11 CDI87288.1 - 0.0054 16.0 0.0 0.0086 15.3 0.0 1.2 1 0 0 1 1 1 1 Tail length tape measure protein RF3_C PF16658.5 CDI87288.1 - 0.031 14.1 0.0 0.063 13.1 0.0 1.5 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain GTP_EFTU_D2 PF03144.25 CDI87288.1 - 0.17 12.3 1.3 9.6 6.7 0.1 3.0 3 0 0 3 3 3 0 Elongation factor Tu domain 2 EFG_II PF14492.6 CDI87288.1 - 0.18 11.9 0.1 1.8 8.7 0.1 2.4 1 1 0 1 1 1 0 Elongation Factor G, domain II MnmE_helical PF12631.7 CDI87288.1 - 0.21 11.7 0.0 0.32 11.1 0.0 1.3 1 0 0 1 1 1 0 MnmE helical domain T2SSM PF04612.12 CDI87289.1 - 0.00067 19.7 0.4 0.0016 18.5 0.4 1.6 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein M Ferric_reduct PF01794.19 CDI87289.1 - 0.028 14.5 0.1 0.048 13.8 0.1 1.5 1 0 0 1 1 1 0 Ferric reductase like transmembrane component DUF4079 PF13301.6 CDI87289.1 - 0.038 14.2 0.1 0.052 13.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) RNase_P_Rpp14 PF01900.19 CDI87289.1 - 0.047 13.9 0.0 0.072 13.3 0.0 1.3 1 0 0 1 1 1 0 Rpp14/Pop5 family EcsC PF12787.7 CDI87289.1 - 2.1 8.0 6.1 0.61 9.7 2.3 1.8 2 0 0 2 2 2 0 EcsC protein family Sec63 PF02889.16 CDI87290.1 - 4.8e-138 458.5 0.0 5.9e-84 281.2 0.0 2.4 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 CDI87290.1 - 4.9e-42 143.7 1.6 6.5e-25 87.9 0.1 2.9 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 CDI87290.1 - 2.1e-32 111.6 0.6 6.8e-32 110.0 0.6 2.0 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 CDI87290.1 - 3.6e-18 66.1 0.0 2.5e-13 50.4 0.0 2.7 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDI87290.1 - 7.2e-13 48.8 0.0 2.1e-07 31.3 0.0 3.8 2 2 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 CDI87290.1 - 0.0013 19.0 0.5 0.17 12.1 0.2 3.4 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 CDI87290.1 - 0.13 12.7 0.0 0.62 10.5 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Pkinase_Tyr PF07714.17 CDI87291.1 - 0.00024 20.5 0.0 0.00047 19.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDI87291.1 - 0.0029 17.0 0.0 0.0049 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Bindin PF02084.15 CDI87293.1 - 0.089 13.0 1.7 0.55 10.5 0.5 2.1 2 0 0 2 2 2 0 Bindin SR-25 PF10500.9 CDI87295.1 - 4.6e-06 26.4 8.5 4.6e-06 26.4 8.5 10.0 4 3 3 9 9 9 1 Nuclear RNA-splicing-associated protein AAA_23 PF13476.6 CDI87295.1 - 0.0035 17.9 6.8 0.0035 17.9 6.8 4.2 4 1 0 4 4 4 1 AAA domain RskA PF10099.9 CDI87295.1 - 0.016 15.5 92.9 0.023 15.0 1.7 7.3 4 2 2 6 6 6 0 Anti-sigma-K factor rskA Ribosomal_60s PF00428.19 CDI87298.1 - 0.0085 16.7 2.4 0.011 16.3 2.4 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein GT87 PF09594.10 CDI87298.1 - 0.023 14.4 0.0 0.024 14.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 87 CSG2 PF16965.5 CDI87298.1 - 0.1 11.5 1.3 0.11 11.4 1.3 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 CDI87298.1 - 0.16 11.0 0.3 0.16 11.0 0.3 1.1 1 0 0 1 1 1 0 CLN3 protein Ribosomal_L12_N PF16320.5 CDI87298.1 - 0.6 9.9 6.0 1.5 8.6 6.0 1.6 1 1 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain DUF3138 PF11336.8 CDI87298.1 - 1.8 7.1 8.1 1.9 7.0 8.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Coilin_N PF15862.5 CDI87298.1 - 2 8.2 10.2 2.3 8.0 10.2 1.1 1 0 0 1 1 1 0 Coilin N-terminus Kei1 PF08552.11 CDI87298.1 - 2.1 8.2 6.4 2.2 8.1 6.4 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Presenilin PF01080.17 CDI87298.1 - 8.7 5.0 10.3 9.1 4.9 10.3 1.1 1 0 0 1 1 1 0 Presenilin PNISR PF15996.5 CDI87299.1 - 0.018 15.3 0.3 0.018 15.3 0.3 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR IPP-2 PF04979.14 CDI87299.1 - 1 10.1 12.6 0.66 10.7 7.1 2.2 2 0 0 2 2 2 0 Protein phosphatase inhibitor 2 (IPP-2) Apt1 PF10351.9 CDI87299.1 - 2.4 6.9 13.9 0.029 13.2 3.5 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain Lin-8 PF03353.15 CDI87299.1 - 5.6 6.4 17.3 0.027 14.0 3.4 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 CDI87299.1 - 6.3 5.4 16.3 14 4.3 10.5 2.5 3 0 0 3 3 3 0 Presenilin DUF2448 PF10476.9 CDI87299.1 - 6.4 6.6 6.0 0.68 9.8 0.1 2.2 2 1 1 3 3 3 0 Protein of unknown function C-terminus (DUF2448) TMEM208_SND2 PF05620.11 CDI87299.1 - 7 6.4 10.7 4.1 7.2 1.7 2.9 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 Activator_LAG-3 PF11498.8 CDI87302.1 - 0.00013 21.1 25.6 0.00013 21.1 25.6 7.6 5 2 1 6 6 6 2 Transcriptional activator LAG-3 DUF2722 PF10846.8 CDI87302.1 - 0.0013 17.8 19.3 0.0013 17.8 19.3 10.6 5 2 2 8 8 8 2 Protein of unknown function (DUF2722) PalH PF08733.10 CDI87302.1 - 0.07 12.1 0.0 0.07 12.1 0.0 3.2 3 1 0 3 3 3 0 PalH/RIM21 Diphthamide_syn PF01866.17 CDI87303.1 - 0.093 12.2 0.3 0.15 11.5 0.3 1.3 1 0 0 1 1 1 0 Putative diphthamide synthesis protein DUF3402 PF11882.8 CDI87303.1 - 0.84 8.7 24.8 0.02 14.0 17.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3402) PH_4 PF15404.6 CDI87303.1 - 2.8 7.7 10.9 1.2 8.9 4.5 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain SEEEED PF14797.6 CDI87304.1 - 2.2 8.5 53.4 4 7.6 33.6 2.3 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex SR-25 PF10500.9 CDI87304.1 - 3.2 7.3 70.0 4.6 6.8 42.8 2.4 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein DDRGK PF09756.9 CDI87304.1 - 4.2 6.9 43.2 0.33 10.5 25.6 2.1 2 0 0 2 2 2 0 DDRGK domain Coprogen_oxidas PF01218.18 CDI87305.1 - 4.6e-11 42.0 10.6 4.6e-11 42.0 10.6 3.9 2 1 1 3 3 2 1 Coproporphyrinogen III oxidase Otopetrin PF03189.13 CDI87305.1 - 4e-10 39.1 2.4 4e-10 39.1 2.4 2.3 2 1 0 2 2 2 1 Otopetrin Activator_LAG-3 PF11498.8 CDI87305.1 - 0.00034 19.7 41.1 0.00034 19.7 41.1 4.2 2 1 1 3 3 1 1 Transcriptional activator LAG-3 FAM60A PF15396.6 CDI87305.1 - 0.0021 18.1 45.5 0.088 12.8 18.4 3.2 3 0 0 3 3 3 2 Protein Family FAM60A MDM10 PF12519.8 CDI87305.1 - 0.0042 16.0 14.5 0.0042 16.0 14.5 3.1 3 0 0 3 3 3 2 Mitochondrial distribution and morphology protein 10 Spore_coat_CotO PF14153.6 CDI87305.1 - 0.0047 16.9 15.3 0.0047 16.9 15.3 3.4 3 0 0 3 3 3 1 Spore coat protein CotO MAP7 PF05672.11 CDI87305.1 - 0.01 15.5 20.3 0.01 15.5 20.3 3.2 3 0 0 3 3 3 0 MAP7 (E-MAP-115) family CDC45 PF02724.14 CDI87305.1 - 0.01 14.2 46.1 0.024 12.9 18.4 3.1 3 0 0 3 3 3 0 CDC45-like protein RR_TM4-6 PF06459.12 CDI87305.1 - 0.014 15.3 65.6 0.049 13.4 26.9 3.2 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.10 CDI87305.1 - 0.024 15.0 60.4 0.07 13.5 13.9 3.1 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 PTPRCAP PF15713.5 CDI87305.1 - 0.061 13.6 60.0 0.13 12.5 21.3 3.3 3 0 0 3 3 3 0 Protein tyrosine phosphatase receptor type C-associated PNISR PF15996.5 CDI87305.1 - 0.063 13.5 71.5 0.51 10.6 16.7 3.2 3 0 0 3 3 3 0 Arginine/serine-rich protein PNISR Peptidase_S49_N PF08496.10 CDI87305.1 - 0.2 11.7 56.0 1.3 9.1 20.5 3.6 3 0 0 3 3 3 0 Peptidase family S49 N-terminal CSG2 PF16965.5 CDI87305.1 - 0.23 10.4 36.0 0.01 14.8 10.4 3.1 3 0 0 3 3 3 0 Ceramide synthase regulator FAM76 PF16046.5 CDI87305.1 - 0.57 9.5 60.7 0.21 10.9 22.9 3.1 3 0 0 3 3 3 0 FAM76 protein XRN_M PF17846.1 CDI87305.1 - 0.57 9.1 40.7 0.047 12.6 13.6 3.2 3 0 0 3 3 3 0 Xrn1 helical domain Band_3_cyto PF07565.13 CDI87305.1 - 1 9.1 63.4 0.43 10.3 14.0 3.2 3 0 0 3 3 3 0 Band 3 cytoplasmic domain V_ATPase_I PF01496.19 CDI87305.1 - 1.6 6.6 61.2 0.22 9.4 24.7 3.1 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family Tim54 PF11711.8 CDI87305.1 - 1.7 7.4 56.9 0.018 13.8 15.8 3.2 3 0 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 DUF2052 PF09747.9 CDI87305.1 - 1.8 8.6 65.7 1.7 8.8 14.7 3.1 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) BORG_CEP PF14957.6 CDI87305.1 - 1.9 9.6 48.1 0.77 10.9 10.1 3.2 3 0 0 3 3 3 0 Cdc42 effector YABBY PF04690.13 CDI87305.1 - 2.6 8.6 52.4 1.3 9.6 11.0 3.4 3 0 0 3 3 3 0 YABBY protein MMR1 PF08505.10 CDI87305.1 - 2.6 8.3 77.6 0.035 14.4 14.6 3.3 3 0 0 3 3 3 0 Mitochondrial Myo2 receptor-related protein ATP11 PF06644.11 CDI87305.1 - 2.7 7.7 62.7 1.6 8.5 13.8 3.6 3 0 0 3 3 3 0 ATP11 protein CobT PF06213.12 CDI87305.1 - 3.3 7.0 90.7 0.013 14.9 20.0 3.4 3 0 0 3 3 3 0 Cobalamin biosynthesis protein CobT YL1 PF05764.13 CDI87305.1 - 6.9 6.7 62.3 1.5 8.9 12.5 2.2 2 0 0 2 2 2 0 YL1 nuclear protein SUFU_C PF12470.8 CDI87305.1 - 7.4 6.6 42.5 0.077 13.0 12.7 3.3 3 0 0 3 3 3 0 Suppressor of Fused Gli/Ci N terminal binding domain TCP PF03634.13 CDI87305.1 - 7.7 7.1 70.3 3 8.4 19.1 3.4 3 0 0 3 3 3 0 TCP family transcription factor Sec62 PF03839.16 CDI87305.1 - 8 5.9 57.1 0.089 12.3 20.5 3.1 3 0 0 3 3 3 0 Translocation protein Sec62 SR-25 PF10500.9 CDI87306.1 - 0.00014 21.6 20.2 0.00016 21.3 20.2 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 CDI87306.1 - 0.3 9.8 34.6 0.4 9.4 34.6 1.1 1 0 0 1 1 1 0 Presenilin BAF1_ABF1 PF04684.13 CDI87306.1 - 0.42 9.6 29.6 0.52 9.3 29.6 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor PBP1_TM PF14812.6 CDI87306.1 - 0.51 10.7 7.5 0.32 11.4 1.9 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Hamartin PF04388.12 CDI87306.1 - 0.82 8.3 26.4 0.98 8.0 26.4 1.0 1 0 0 1 1 1 0 Hamartin protein DUF572 PF04502.13 CDI87306.1 - 2.3 7.8 23.7 3.4 7.2 23.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) TFIIA PF03153.13 CDI87306.1 - 4.5 7.2 66.8 7.1 6.5 66.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3984 PF13136.6 CDI87306.1 - 6.3 6.1 30.1 8.5 5.7 30.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) PvlArgDC PF01862.16 CDI87306.1 - 7.2 6.4 8.0 4.2 7.1 5.9 1.7 1 1 1 2 2 2 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) DUF4569 PF15133.6 CDI87306.1 - 7.5 6.2 32.4 9.5 5.8 32.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) SR-25 PF10500.9 CDI87307.1 - 0.048 13.3 8.6 0.046 13.3 8.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2057 PF09829.9 CDI87307.1 - 7.5 6.7 18.7 7.9 6.6 18.7 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) Spt20 PF12090.8 CDI87307.1 - 8.7 5.9 14.0 8.7 5.9 14.0 1.1 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI87308.1 - 0.028 14.4 47.6 0.037 14.0 47.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Utp14 PF04615.13 CDI87308.1 - 1.2 7.6 39.7 1.5 7.3 39.7 1.0 1 0 0 1 1 1 0 Utp14 protein DUF966 PF06136.13 CDI87308.1 - 7.5 6.2 45.1 9.3 5.9 45.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) CDT1 PF08839.11 CDI87309.1 - 0.011 16.0 0.2 0.022 15.1 0.2 1.5 1 0 0 1 1 1 0 DNA replication factor CDT1 like POPLD PF08170.12 CDI87309.1 - 0.058 13.7 1.0 0.058 13.7 1.0 2.4 2 0 0 2 2 2 0 POPLD (NUC188) domain DUF1180 PF06679.12 CDI87309.1 - 0.24 11.8 0.0 0.24 11.8 0.0 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1180) Med15 PF09606.10 CDI87309.1 - 0.87 8.2 27.3 0.012 14.3 8.5 2.0 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2722 PF10846.8 CDI87309.1 - 1 8.2 22.8 0.066 12.1 13.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) RNase_H2_suC PF08615.11 CDI87309.1 - 1.2 9.3 4.3 3.3 7.9 4.2 1.8 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DFRP_C PF16543.5 CDI87309.1 - 1.8 9.1 7.2 5.5 7.6 1.0 2.7 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 EMC3_TMCO1 PF01956.16 CDI87309.1 - 2.1 8.0 6.6 13 5.5 1.8 2.2 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DUF4834 PF16118.5 CDI87309.1 - 5.1 8.1 13.6 0.57 11.2 3.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF4770 PF15994.5 CDI87309.1 - 7.4 6.8 11.6 3.7 7.7 4.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Ham1p_like PF01725.16 CDI87310.1 - 1.1e-14 54.8 1.4 1.3e-14 54.6 1.4 1.1 1 0 0 1 1 1 1 Ham1 family DUF2722 PF10846.8 CDI87310.1 - 3.8e-06 26.1 10.2 3.8e-06 26.1 10.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spore_coat_CotO PF14153.6 CDI87310.1 - 5e-05 23.3 0.5 9.7e-05 22.4 0.5 1.4 1 1 0 1 1 1 1 Spore coat protein CotO TFIIA PF03153.13 CDI87310.1 - 0.00012 22.3 12.9 0.00012 22.3 12.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit TAF4 PF05236.14 CDI87310.1 - 0.0017 18.2 5.5 0.0021 17.9 5.5 1.1 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Med15 PF09606.10 CDI87310.1 - 0.0091 14.7 16.0 0.0088 14.8 16.0 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal SpoIIP PF07454.11 CDI87310.1 - 0.0095 15.4 3.0 0.0088 15.5 3.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CDI87310.1 - 0.018 13.8 5.2 0.017 13.9 5.2 1.1 1 0 0 1 1 1 0 Presenilin TRAPPC9-Trs120 PF08626.11 CDI87310.1 - 0.019 12.3 2.0 0.023 12.0 2.0 1.0 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit DUF2126 PF09899.9 CDI87310.1 - 0.024 12.7 4.4 0.032 12.3 4.4 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Band_3_cyto PF07565.13 CDI87310.1 - 0.03 14.1 2.7 0.03 14.1 2.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain V_ATPase_I PF01496.19 CDI87310.1 - 0.068 11.1 3.8 0.061 11.2 3.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PepSY_TM PF03929.16 CDI87310.1 - 0.069 12.8 1.5 0.072 12.7 1.5 1.1 1 0 0 1 1 1 0 PepSY-associated TM region OATP PF03137.20 CDI87310.1 - 0.22 9.7 1.5 0.19 10.0 1.5 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Pannexin_like PF12534.8 CDI87310.1 - 0.25 10.4 4.3 0.34 9.9 4.3 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Ctr PF04145.15 CDI87310.1 - 0.28 11.8 1.2 0.3 11.7 1.2 1.2 1 0 0 1 1 1 0 Ctr copper transporter family USP8_interact PF08941.10 CDI87310.1 - 1.2 8.9 11.4 1.3 8.8 8.3 1.9 2 0 0 2 2 2 0 USP8 interacting DUF4834 PF16118.5 CDI87310.1 - 1.5 9.9 14.0 0.68 10.9 11.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Neur_chan_memb PF02932.16 CDI87310.1 - 1.6 8.8 5.3 2.2 8.2 5.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Orf78 PF06024.12 CDI87310.1 - 2.4 8.5 5.8 4.7 7.6 5.8 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Suf PF05843.14 CDI87310.1 - 2.8 7.8 15.0 3.7 7.4 15.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CPSF100_C PF13299.6 CDI87310.1 - 3.2 7.9 9.3 5.1 7.3 8.8 1.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF3464 PF11947.8 CDI87310.1 - 3.6 7.3 11.1 6.7 6.5 11.1 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF3043 PF11241.8 CDI87310.1 - 3.9 7.5 11.5 3.1 7.8 10.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3043) CLN3 PF02487.17 CDI87310.1 - 5 6.1 6.8 7.4 5.5 6.8 1.2 1 0 0 1 1 1 0 CLN3 protein eIF-3_zeta PF05091.12 CDI87310.1 - 5.2 5.9 15.6 7 5.5 15.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_S49_N PF08496.10 CDI87310.1 - 6.1 6.9 11.2 1.2 9.1 8.0 1.4 2 0 0 2 2 1 0 Peptidase family S49 N-terminal CobT PF06213.12 CDI87310.1 - 6.2 6.1 17.4 9.9 5.5 17.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pex14_N PF04695.13 CDI87310.1 - 6.5 7.4 17.2 10 6.7 17.2 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MCU PF04678.13 CDI87310.1 - 6.7 6.8 11.7 2.7 8.1 9.3 1.5 2 0 0 2 2 2 0 Mitochondrial calcium uniporter Folate_carrier PF01770.18 CDI87310.1 - 7.7 5.1 5.7 10 4.8 5.7 1.2 1 0 0 1 1 1 0 Reduced folate carrier SR-25 PF10500.9 CDI87311.1 - 0.00033 20.3 7.8 0.00033 20.3 7.8 4.5 3 1 1 4 4 4 1 Nuclear RNA-splicing-associated protein CCSAP PF15748.5 CDI87311.1 - 0.029 14.5 0.2 0.029 14.5 0.2 3.8 3 1 0 3 3 3 0 Centriole, cilia and spindle-associated SPX PF03105.19 CDI87311.1 - 0.14 12.1 20.9 0.17 11.8 7.8 2.5 2 1 0 2 2 2 0 SPX domain Peptidase_S64 PF08192.11 CDI87311.1 - 2.8 6.3 24.4 2.9 6.3 6.0 2.3 2 0 0 2 2 2 0 Peptidase family S64 SPX PF03105.19 CDI87312.1 - 0.029 14.3 7.0 0.037 13.9 7.0 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI87312.1 - 5.1 5.8 10.1 7.2 5.3 10.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain UreE_N PF02814.15 CDI87313.1 - 0.22 11.1 2.1 1.1 8.9 2.1 2.3 1 0 0 1 1 1 0 UreE urease accessory protein, N-terminal domain CD20 PF04103.15 CDI87313.1 - 0.41 10.7 0.0 0.41 10.7 0.0 3.6 4 1 0 4 4 4 0 CD20-like family SLC12 PF03522.15 CDI87313.1 - 2.2 7.2 19.1 1.3 8.0 7.0 2.2 2 0 0 2 2 2 0 Solute carrier family 12 Band_3_cyto PF07565.13 CDI87313.1 - 7.8 6.2 23.2 2.3 7.9 4.6 3.3 2 1 0 2 2 2 0 Band 3 cytoplasmic domain Caldesmon PF02029.15 CDI87314.1 - 9e-07 28.0 31.3 8.8e-06 24.8 15.7 2.9 3 0 0 3 3 3 2 Caldesmon Eapp_C PF10238.9 CDI87314.1 - 0.01 15.9 2.2 0.01 15.9 2.2 4.7 4 1 1 5 5 5 0 E2F-associated phosphoprotein AF-4 PF05110.13 CDI87314.1 - 0.068 11.3 94.6 0.058 11.5 39.9 4.2 4 0 0 4 4 4 0 AF-4 proto-oncoprotein DUF4746 PF15928.5 CDI87314.1 - 2.1 7.7 35.9 0.54 9.6 1.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) SIR2 PF02146.17 CDI87315.1 - 2.4e-09 37.4 5.5 6.9e-05 22.9 0.0 4.1 2 1 1 3 3 3 3 Sir2 family SUIM_assoc PF16619.5 CDI87315.1 - 0.0035 17.4 2.8 0.0035 17.4 2.8 11.6 7 3 1 9 9 9 2 Unstructured region C-term to UIM in Ataxin3 Acetyltransf_5 PF13444.6 CDI87315.1 - 0.055 14.2 0.2 0.5 11.1 0.1 2.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain UCH PF00443.29 CDI87318.1 - 8.3e-15 55.0 0.0 1.5e-14 54.1 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase TPR_12 PF13424.6 CDI87319.1 - 0.0012 19.1 12.0 0.022 15.1 0.3 3.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 CDI87319.1 - 0.052 14.2 0.4 26 5.8 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDI87319.1 - 0.098 13.2 0.1 0.098 13.2 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDI87319.1 - 1.5 9.8 9.3 1.2 10.1 0.3 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDI87319.1 - 1.6 9.1 9.9 2.8 8.4 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat YccV-like PF08755.11 CDI87320.1 - 2.3e-19 69.7 0.0 3.9e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like PRKCSH PF07915.13 CDI87320.1 - 1.1e-11 45.5 0.0 1.5e-05 25.9 0.0 2.9 2 1 0 2 2 2 2 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 CDI87320.1 - 0.0034 17.1 0.0 0.63 9.7 0.0 2.4 2 0 0 2 2 2 2 Glucosidase II beta subunit-like protein PH_2 PF08458.10 CDI87321.1 - 0.032 14.6 3.1 1.8 8.9 0.0 3.6 2 1 1 3 3 3 0 Plant pleckstrin homology-like region Fusion_gly PF00523.18 CDI87321.1 - 0.19 9.9 1.6 0.26 9.5 0.0 1.8 2 0 0 2 2 2 0 Fusion glycoprotein F0 UvrD-helicase PF00580.21 CDI87322.1 - 1.1e-47 163.1 0.0 1.7e-43 149.4 0.0 2.2 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 CDI87322.1 - 4.8e-33 115.0 0.0 3e-26 92.6 0.0 4.0 3 2 0 3 3 3 3 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CDI87322.1 - 6.1e-19 68.8 0.0 1.8e-18 67.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CDI87322.1 - 1.2e-10 41.1 2.0 0.00023 20.9 0.0 3.1 3 0 0 3 3 3 2 UvrD-like helicase C-terminal domain EPL1 PF10513.9 CDI87322.1 - 0.55 10.6 13.2 0.056 13.8 8.1 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like PTPRCAP PF15713.5 CDI87322.1 - 1.1 9.5 20.5 0.068 13.5 14.4 2.1 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated NPR3 PF03666.13 CDI87322.1 - 2 7.1 17.7 3.4 6.3 17.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.16 CDI87322.1 - 2.3 8.2 10.3 3.2 7.7 8.6 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 CDI87322.1 - 2.6 6.2 13.3 3.8 5.7 13.3 1.1 1 0 0 1 1 1 0 CDC45-like protein AAA_11 PF13086.6 CDI87322.1 - 3.6 7.3 20.5 10 5.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain DHO_dh PF01180.21 CDI87323.1 - 2.9e-75 253.2 0.1 2.3e-70 237.1 0.0 2.2 1 1 1 2 2 2 2 Dihydroorotate dehydrogenase FMN_dh PF01070.18 CDI87323.1 - 0.011 14.7 0.1 0.026 13.6 0.1 1.6 1 0 0 1 1 1 0 FMN-dependent dehydrogenase FAM92 PF06730.11 CDI87323.1 - 0.037 13.4 0.3 0.068 12.6 0.3 1.4 1 0 0 1 1 1 0 FAM92 protein DUF1323 PF07037.11 CDI87323.1 - 0.069 13.5 0.1 7.6 7.0 0.1 2.5 1 1 1 2 2 2 0 Putative transcription regulator (DUF1323) SAC3_GANP PF03399.16 CDI87324.1 - 0.41 10.0 2.6 6.2 6.1 0.1 2.2 2 0 0 2 2 2 0 SAC3/GANP family RAP1 PF07218.11 CDI87326.1 - 4.9 5.3 20.0 5.6 5.1 20.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) HSD3 PF15244.6 CDI87326.1 - 8.8 5.7 36.0 11 5.5 36.0 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 SUIM_assoc PF16619.5 CDI87327.1 - 0.012 15.7 0.5 0.012 15.7 0.5 4.7 5 0 0 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI87327.1 - 0.47 10.0 32.2 1.2 8.7 3.9 3.3 3 0 0 3 3 3 0 Spt20 family TAF4 PF05236.14 CDI87328.1 - 0.0027 17.5 6.3 0.0027 17.5 6.3 7.0 5 2 1 6 6 6 1 Transcription initiation factor TFIID component TAF4 family CcmD PF04995.14 CDI87329.1 - 0.0086 16.1 0.1 0.0086 16.1 0.1 12.0 3 3 2 5 5 5 1 Heme exporter protein D (CcmD) TMEM220 PF15071.6 CDI87329.1 - 6 7.7 5.7 22 5.8 5.7 2.1 1 1 0 1 1 1 0 Transmembrane family 220, helix Kelch_3 PF13415.6 CDI87330.1 - 2.2e-21 75.6 14.3 6.5e-09 35.9 0.6 5.3 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.6 CDI87330.1 - 1.5e-20 72.9 7.7 1.7e-05 24.7 0.8 4.6 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI87330.1 - 1.8e-20 72.5 5.3 2.1e-05 24.4 0.8 4.8 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 CDI87330.1 - 9.3e-13 47.6 15.7 0.0011 18.9 0.8 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.6 CDI87330.1 - 8e-11 41.8 15.0 6e-06 26.4 0.6 4.8 2 1 3 5 5 5 3 Kelch motif Kelch_1 PF01344.25 CDI87330.1 - 6.5e-08 32.0 16.2 0.0058 16.2 0.2 5.5 5 1 0 5 5 5 3 Kelch motif Yuri_gagarin PF15934.5 CDI87330.1 - 0.0017 18.2 0.9 0.0024 17.7 0.9 1.1 1 0 0 1 1 1 1 Yuri gagarin Prefoldin_2 PF01920.20 CDI87330.1 - 0.0073 16.2 1.0 0.013 15.5 1.0 1.4 1 0 0 1 1 1 1 Prefoldin subunit DUF4678 PF15727.5 CDI87330.1 - 0.01 15.1 0.1 0.015 14.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4678) DUF601 PF04642.12 CDI87330.1 - 0.014 14.9 0.4 0.021 14.4 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF601 DUF4795 PF16043.5 CDI87330.1 - 0.016 14.9 0.3 0.021 14.4 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) DUF241 PF03087.14 CDI87330.1 - 0.03 14.2 0.0 0.042 13.7 0.0 1.2 1 0 0 1 1 1 0 Arabidopsis protein of unknown function adh_short_C2 PF13561.6 CDI87331.1 - 0.00024 20.7 0.0 0.001 18.7 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDI87331.1 - 0.002 17.6 0.0 0.0041 16.6 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase E2F_TDP PF02319.20 CDI87331.1 - 0.015 15.3 0.0 0.86 9.7 0.0 2.5 2 1 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain BPD_transp_2 PF02653.16 CDI87332.1 - 0.0015 17.7 0.2 0.022 13.9 0.0 2.2 2 1 0 2 2 2 1 Branched-chain amino acid transport system / permease component SUIM_assoc PF16619.5 CDI87332.1 - 0.0015 18.5 0.0 0.0015 18.5 0.0 7.5 1 1 2 4 4 1 1 Unstructured region C-term to UIM in Ataxin3 TRAP_alpha PF03896.16 CDI87332.1 - 0.0038 16.5 7.6 0.0038 16.5 7.6 2.7 1 1 2 3 3 2 1 Translocon-associated protein (TRAP), alpha subunit PAT1 PF09770.9 CDI87332.1 - 0.0066 14.8 61.6 0.0076 14.6 61.6 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Phage_Gp23 PF10669.9 CDI87332.1 - 0.0077 16.6 12.3 0.0077 16.6 12.3 2.9 1 1 2 3 3 2 1 Protein gp23 (Bacteriophage A118) Connexin PF00029.19 CDI87332.1 - 0.017 14.9 8.8 0.017 14.9 8.8 3.0 1 1 1 2 2 1 0 Connexin DUF1772 PF08592.11 CDI87332.1 - 0.017 15.4 3.1 0.038 14.3 3.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) TctB PF07331.11 CDI87332.1 - 0.023 15.0 0.0 0.12 12.6 0.0 2.0 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family LptF_LptG PF03739.14 CDI87332.1 - 0.11 11.3 18.6 16 4.2 18.6 2.1 1 1 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Hamartin PF04388.12 CDI87332.1 - 0.8 8.3 36.4 0.93 8.1 36.4 1.1 1 0 0 1 1 1 0 Hamartin protein LAP1C PF05609.12 CDI87332.1 - 1.6 7.7 45.5 2.1 7.3 45.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) TAP42 PF04177.12 CDI87333.1 - 0.00024 20.3 0.8 0.00032 19.9 0.8 1.2 1 0 0 1 1 1 1 TAP42-like family NTPase_I-T PF01931.18 CDI87333.1 - 0.063 13.1 0.0 0.078 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF84 Macoilin PF09726.9 CDI87333.1 - 0.67 8.4 7.4 0.79 8.2 7.4 1.0 1 0 0 1 1 1 0 Macoilin family Rtf2 PF04641.12 CDI87334.1 - 9.7 5.5 29.6 10 5.4 29.6 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Trp_oprn_chp PF09534.10 CDI87335.1 - 0.0092 15.8 15.6 0.054 13.3 13.2 2.4 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2076 PF09849.9 CDI87335.1 - 1 9.3 41.1 0.22 11.5 37.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Med15 PF09606.10 CDI87335.1 - 1.4 7.6 41.5 1.9 7.1 41.5 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal EphA2_TM PF14575.6 CDI87335.1 - 6 7.8 6.1 4.8 8.1 0.4 2.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF5521 PF17659.1 CDI87335.1 - 9.4 3.9 10.5 13 3.4 10.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5521) GTP_EFTU PF00009.27 CDI87336.1 - 1e-17 64.3 0.0 1.2e-17 64.0 0.0 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain PIP5K PF01504.18 CDI87337.1 - 0.00062 19.1 0.9 0.00062 19.1 0.9 8.4 4 1 3 8 8 8 2 Phosphatidylinositol-4-phosphate 5-Kinase DUF4207 PF13904.6 CDI87337.1 - 0.0011 18.7 30.1 0.0011 18.7 30.1 8.4 5 1 3 8 8 8 1 Domain of unknown function (DUF4207) Pex14_N PF04695.13 CDI87337.1 - 0.0017 19.1 24.9 0.0017 19.1 24.9 13.8 5 4 4 9 9 9 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1772 PF08592.11 CDI87337.1 - 2.1 8.7 0.0 2.1 8.7 0.0 7.6 4 2 1 6 6 6 0 Domain of unknown function (DUF1772) SID-1_RNA_chan PF13965.6 CDI87338.1 - 0.049 12.1 7.8 0.06 11.8 7.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 O-antigen_lig PF13425.6 CDI87338.1 - 0.13 11.0 5.5 0.15 10.8 5.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF726 PF05277.12 CDI87338.1 - 0.57 9.1 10.3 0.75 8.7 10.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) MYT1 PF08474.11 CDI87338.1 - 8.3 6.3 14.2 12 5.7 14.2 1.2 1 0 0 1 1 1 0 Myelin transcription factor 1 RskA PF10099.9 CDI87339.1 - 0.019 15.3 21.2 0.019 15.3 21.2 2.6 1 1 1 2 2 2 0 Anti-sigma-K factor rskA 7TM_GPCR_Srw PF10324.9 CDI87343.1 - 1.2 8.4 8.6 0.087 12.1 0.6 2.3 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw STE3 PF02076.15 CDI87345.1 - 0.24 10.6 0.1 0.35 10.0 0.1 1.2 1 0 0 1 1 1 0 Pheromone A receptor HemY_N PF07219.13 CDI87347.1 - 0.057 13.6 0.1 0.58 10.4 0.0 2.5 2 0 0 2 2 2 0 HemY protein N-terminus Mod_r PF07200.13 CDI87347.1 - 7.4 6.7 10.3 11 6.1 2.0 2.8 3 1 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein RabGAP-TBC PF00566.18 CDI87349.1 - 3.5e-06 26.8 0.1 3.5e-06 26.8 0.1 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain PNISR PF15996.5 CDI87350.1 - 7.4 6.8 20.3 11 6.2 20.3 1.4 1 1 0 1 1 1 0 Arginine/serine-rich protein PNISR SR-25 PF10500.9 CDI87351.1 - 0.0028 17.3 9.4 0.0037 16.9 9.4 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein AAA_23 PF13476.6 CDI87351.1 - 0.17 12.4 9.5 0.18 12.3 9.5 1.0 1 0 0 1 1 1 0 AAA domain DUF5321 PF17254.2 CDI87351.1 - 0.31 10.5 12.2 0.38 10.2 12.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5321) TCP PF03634.13 CDI87351.1 - 1.1 9.9 13.8 1.1 9.7 13.8 1.1 1 0 0 1 1 1 0 TCP family transcription factor SelP_N PF04592.14 CDI87351.1 - 3.5 7.0 21.7 4 6.8 21.7 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SprA-related PF12118.8 CDI87351.1 - 3.9 6.5 19.7 4.3 6.4 19.7 1.1 1 0 0 1 1 1 0 SprA-related family STAC2_u1 PF16664.5 CDI87351.1 - 5 7.6 13.8 6 7.3 13.8 1.1 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 KHA PF11834.8 CDI87352.1 - 0.048 13.7 0.7 0.2 11.8 0.7 2.2 1 1 0 1 1 1 0 KHA, dimerisation domain of potassium ion channel DUF3527 PF12043.8 CDI87352.1 - 0.35 10.4 35.3 0.41 10.2 35.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) YL1 PF05764.13 CDI87352.1 - 6.6 6.8 38.0 9.3 6.3 38.0 1.2 1 0 0 1 1 1 0 YL1 nuclear protein BAF1_ABF1 PF04684.13 CDI87353.1 - 1.1 8.3 23.7 1.2 8.2 23.7 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Cyclin_C PF02984.19 CDI87353.1 - 3.5 7.7 15.6 4 7.6 15.6 1.1 1 0 0 1 1 1 0 Cyclin, C-terminal domain STAC2_u1 PF16664.5 CDI87353.1 - 4.7 7.7 19.0 5.1 7.6 19.0 1.1 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Presenilin PF01080.17 CDI87353.1 - 5.5 5.7 35.3 5.6 5.6 35.3 1.0 1 0 0 1 1 1 0 Presenilin CSG2 PF16965.5 CDI87353.1 - 9.4 5.1 15.8 9.5 5.1 15.8 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Connexin PF00029.19 CDI87353.1 - 9.4 5.9 20.9 13 5.5 20.9 1.4 1 0 0 1 1 1 0 Connexin Kei1 PF08552.11 CDI87354.1 - 0.0034 17.3 4.3 0.005 16.7 4.3 1.3 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 Vfa1 PF08432.10 CDI87354.1 - 0.072 13.4 52.0 0.12 12.7 52.0 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 CDI87354.1 - 0.078 12.8 41.5 0.087 12.6 41.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI87354.1 - 0.13 11.0 26.4 0.15 10.8 26.4 1.0 1 0 0 1 1 1 0 Presenilin HCO3_cotransp PF00955.21 CDI87354.1 - 0.13 11.1 9.5 0.14 11.0 9.5 1.0 1 0 0 1 1 1 0 HCO3- transporter family DUF2828 PF11443.8 CDI87354.1 - 0.15 10.1 31.6 0.2 9.7 31.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PA26 PF04636.13 CDI87354.1 - 0.21 10.5 18.6 0.23 10.4 18.6 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) NPR3 PF03666.13 CDI87354.1 - 0.29 9.9 36.6 0.34 9.7 36.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC12 PF03522.15 CDI87354.1 - 0.29 10.1 31.4 0.32 10.0 31.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Zip PF02535.22 CDI87354.1 - 0.36 10.0 21.4 0.41 9.8 21.4 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2052 PF09747.9 CDI87354.1 - 0.45 10.6 27.7 0.54 10.4 27.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF913 PF06025.12 CDI87354.1 - 0.57 9.1 17.8 0.74 8.7 17.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RPOL_N PF14700.6 CDI87354.1 - 1.1 8.6 35.5 1.7 7.9 35.5 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal ALMT PF11744.8 CDI87354.1 - 1.2 7.8 23.9 1.4 7.6 23.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter MCM_bind PF09739.9 CDI87354.1 - 1.6 7.1 28.8 1.7 7.0 28.8 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor SAPS PF04499.15 CDI87354.1 - 1.7 7.4 20.6 1.9 7.2 20.6 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BORG_CEP PF14957.6 CDI87354.1 - 2.1 9.5 19.4 2.9 9.1 19.4 1.2 1 0 0 1 1 1 0 Cdc42 effector Peptidase_S64 PF08192.11 CDI87354.1 - 2.9 6.3 26.7 3.4 6.0 26.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF2370 PF10176.9 CDI87354.1 - 2.9 7.5 10.8 3.7 7.1 10.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Paramyxo_ncap PF00973.19 CDI87354.1 - 3 6.6 19.9 3.9 6.3 19.9 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DAG_kinase_N PF14513.6 CDI87354.1 - 3.4 7.8 27.3 5.3 7.2 27.3 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Otopetrin PF03189.13 CDI87354.1 - 3.6 6.3 13.8 5.6 5.7 13.8 1.4 1 0 0 1 1 1 0 Otopetrin LicD PF04991.13 CDI87354.1 - 4.4 7.4 34.3 5.5 7.1 34.3 1.1 1 0 0 1 1 1 0 LicD family MDM10 PF12519.8 CDI87354.1 - 4.8 5.9 28.9 5.4 5.8 28.9 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF4050 PF13259.6 CDI87354.1 - 5.2 7.4 20.3 7.4 6.9 20.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) DUF4569 PF15133.6 CDI87354.1 - 5.2 6.7 27.0 5.9 6.5 27.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) CDC45 PF02724.14 CDI87354.1 - 5.7 5.1 38.2 7.1 4.8 38.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 CDI87354.1 - 7.2 4.8 17.4 8.4 4.6 17.4 1.0 1 0 0 1 1 1 0 Menin Caldesmon PF02029.15 CDI87358.1 - 0.016 14.0 38.5 0.019 13.8 38.5 1.2 1 0 0 1 1 1 0 Caldesmon PAT1 PF09770.9 CDI87358.1 - 6.5 4.9 62.3 9.1 4.4 62.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF737 PF05300.11 CDI87359.1 - 3.4 8.0 20.4 4.3 7.7 20.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) DUF5401 PF17380.2 CDI87359.1 - 8.5 4.3 30.5 10 4.1 30.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5401) CDC45 PF02724.14 CDI87360.1 - 0.031 12.6 25.8 0.031 12.6 25.8 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.6 CDI87360.1 - 0.078 13.0 23.8 0.085 12.9 23.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Peptidase_S64 PF08192.11 CDI87360.1 - 0.54 8.7 25.3 0.56 8.6 25.3 1.2 1 0 0 1 1 1 0 Peptidase family S64 Sec62 PF03839.16 CDI87360.1 - 0.59 9.6 27.3 0.62 9.5 27.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 ALMT PF11744.8 CDI87360.1 - 0.69 8.7 27.6 0.78 8.5 27.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter NPR3 PF03666.13 CDI87360.1 - 0.76 8.5 32.0 0.77 8.5 32.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 CDI87360.1 - 0.87 8.3 41.1 0.96 8.1 41.1 1.1 1 0 0 1 1 1 0 Presenilin LAP1C PF05609.12 CDI87360.1 - 1.2 8.1 31.5 1.3 8.0 31.5 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Zip PF02535.22 CDI87360.1 - 1.2 8.3 23.9 1.2 8.3 23.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter AAA_11 PF13086.6 CDI87360.1 - 2.5 7.8 31.8 2.7 7.7 31.8 1.0 1 0 0 1 1 1 0 AAA domain FAM76 PF16046.5 CDI87360.1 - 4.5 6.5 34.0 6.6 6.0 34.0 1.3 1 0 0 1 1 1 0 FAM76 protein DUF2151 PF10221.9 CDI87360.1 - 5.9 5.4 20.7 6.1 5.3 20.7 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator ASC PF00858.24 CDI87360.1 - 7.7 5.4 16.6 7.8 5.3 16.6 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Smg8_Smg9 PF10220.9 CDI87360.1 - 8.1 4.6 29.6 8.3 4.6 29.6 1.0 1 0 0 1 1 1 0 Smg8_Smg9 MDFI PF15316.6 CDI87360.1 - 9.1 6.3 22.8 10 6.2 22.8 1.1 1 0 0 1 1 1 0 MyoD family inhibitor SR-25 PF10500.9 CDI87361.1 - 0.0046 16.6 34.5 0.0046 16.6 34.5 3.1 1 1 2 3 3 3 1 Nuclear RNA-splicing-associated protein AAA_23 PF13476.6 CDI87361.1 - 0.044 14.3 31.8 0.068 13.7 31.8 1.3 1 0 0 1 1 1 0 AAA domain Utp14 PF04615.13 CDI87361.1 - 0.12 10.9 42.4 0.14 10.7 42.4 1.0 1 0 0 1 1 1 0 Utp14 protein SART-1 PF03343.13 CDI87361.1 - 0.69 8.4 37.1 1 7.8 37.1 1.2 1 0 0 1 1 1 0 SART-1 family DUF308 PF03729.13 CDI87363.1 - 0.012 15.9 2.7 11 6.5 0.0 3.2 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) Ni_hydr_CYTB PF01292.20 CDI87363.1 - 0.033 13.8 2.3 0.16 11.6 2.5 1.8 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 Antirestrict PF03230.13 CDI87363.1 - 0.049 13.7 0.5 1.2 9.3 0.1 2.7 2 2 1 3 3 3 0 Antirestriction protein FAM176 PF14851.6 CDI87363.1 - 0.15 11.8 0.1 3.9 7.1 0.0 2.2 1 1 1 2 2 2 0 FAM176 family Hydrolase_4 PF12146.8 CDI87364.1 - 6.9e-18 64.8 0.0 3.1e-14 52.8 0.0 2.0 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDI87364.1 - 4.6e-12 46.1 0.0 4.2e-09 36.4 0.0 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDI87364.1 - 2.3e-11 44.7 0.0 3.2e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CDI87364.1 - 1.1e-09 38.1 0.0 1.7e-09 37.5 0.0 1.3 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 CDI87364.1 - 4.9e-06 26.2 0.0 2.5e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family DUF1057 PF06342.12 CDI87364.1 - 1.5e-05 24.2 0.0 1.7e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Peptidase_S15 PF02129.18 CDI87364.1 - 0.00018 21.2 0.0 0.0012 18.6 0.0 1.8 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) PGAP1 PF07819.13 CDI87364.1 - 0.0003 20.6 0.0 0.00037 20.3 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein DUF818 PF05677.12 CDI87364.1 - 0.00036 19.6 0.0 0.0004 19.5 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Thioesterase PF00975.20 CDI87364.1 - 0.00045 20.4 0.0 0.00061 20.0 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain FSH1 PF03959.13 CDI87364.1 - 0.00077 19.2 0.0 0.0014 18.3 0.0 1.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Lipase_3 PF01764.25 CDI87364.1 - 0.00085 19.2 0.0 0.0018 18.1 0.0 1.4 1 1 0 1 1 1 1 Lipase (class 3) AXE1 PF05448.12 CDI87364.1 - 0.0017 17.1 0.1 0.0053 15.5 0.1 1.8 1 1 1 2 2 2 1 Acetyl xylan esterase (AXE1) BAAT_C PF08840.11 CDI87364.1 - 0.0049 16.8 0.0 0.066 13.1 0.0 1.9 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_5 PF12695.7 CDI87364.1 - 0.0051 16.6 0.0 0.012 15.4 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 CDI87364.1 - 0.016 15.0 0.0 0.028 14.2 0.0 1.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 CDI87364.1 - 0.017 15.0 0.0 0.028 14.3 0.0 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold LIDHydrolase PF10230.9 CDI87364.1 - 0.022 14.3 0.0 0.2 11.2 0.0 1.9 1 1 1 2 2 2 0 Lipid-droplet associated hydrolase PAF-AH_p_II PF03403.13 CDI87364.1 - 0.028 12.9 0.0 0.03 12.8 0.0 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II DUF1188 PF06690.11 CDI87364.1 - 0.044 13.3 0.0 0.06 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) Pro_CA PF00484.19 CDI87364.1 - 0.14 12.4 0.0 0.21 11.9 0.0 1.3 1 1 0 1 1 1 0 Carbonic anhydrase DUF5585 PF17823.1 CDI87365.1 - 2.4 7.0 27.7 2.9 6.7 27.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) PAP1 PF08601.10 CDI87366.1 - 0.2 11.3 0.0 0.2 11.3 0.0 10.7 3 3 7 10 10 10 0 Transcription factor PAP1 Spt20 PF12090.8 CDI87367.1 - 0.00018 21.2 5.7 0.00018 21.2 5.7 5.2 3 1 1 4 4 4 2 Spt20 family DUF4667 PF15700.5 CDI87367.1 - 0.0018 18.4 5.0 0.0018 18.4 5.0 4.2 4 0 0 4 4 4 1 Domain of unknown function (DUF4667) CNDH2_C PF16858.5 CDI87367.1 - 0.91 9.3 48.4 0.69 9.7 8.0 3.3 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SID-1_RNA_chan PF13965.6 CDI87367.1 - 1.1 7.6 18.4 0.33 9.3 1.0 3.0 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 CDI87367.1 - 2.1 7.3 51.5 1.4 7.9 9.2 3.4 3 0 0 3 3 3 0 Solute carrier family 12 Baculo_PP31 PF05311.11 CDI87370.1 - 0.0049 16.4 6.0 0.0049 16.4 6.0 3.3 3 0 0 3 3 3 1 Baculovirus 33KDa late protein (PP31) DUF2722 PF10846.8 CDI87370.1 - 0.1 11.5 62.2 0.029 13.3 6.4 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Activator_LAG-3 PF11498.8 CDI87370.1 - 5.7 5.8 66.2 0.71 8.8 12.8 3.4 3 0 0 3 3 3 0 Transcriptional activator LAG-3 FmiP_Thoc5 PF09766.9 CDI87370.1 - 5.8 6.1 43.4 0.016 14.5 8.9 3.3 3 0 0 3 3 3 0 Fms-interacting protein/Thoc5 eIF-3_zeta PF05091.12 CDI87370.1 - 6.3 5.7 36.5 0.8 8.6 5.4 3.2 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TIMELESS PF04821.14 CDI87371.1 - 1.4 8.1 9.6 0.33 10.2 5.5 2.1 2 0 0 2 2 2 0 Timeless protein DAP_epimerase PF01678.19 CDI87373.1 - 0.11 12.7 0.8 0.45 10.7 0.0 2.3 1 1 1 2 2 2 0 Diaminopimelate epimerase AAA_23 PF13476.6 CDI87373.1 - 0.28 11.6 31.1 1.6 9.2 20.6 2.4 2 0 0 2 2 2 0 AAA domain UPF0564 PF10595.9 CDI87373.1 - 1.1 8.3 42.0 1.1 8.2 6.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0564 Brix PF04427.18 CDI87374.1 - 1.2e-08 35.3 0.3 2.4e-08 34.3 0.3 1.5 1 0 0 1 1 1 1 Brix domain Arf PF00025.21 CDI87376.1 - 1.7e-26 92.7 0.0 1.8e-12 47.1 0.0 2.3 1 1 1 2 2 2 2 ADP-ribosylation factor family DUF2722 PF10846.8 CDI87376.1 - 0.00048 19.2 4.3 0.00048 19.2 4.3 3.9 2 1 2 4 4 4 1 Protein of unknown function (DUF2722) LAP1C PF05609.12 CDI87376.1 - 0.028 13.5 36.2 0.012 14.8 25.4 2.1 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) LEAP-2 PF07359.11 CDI87376.1 - 0.046 13.6 0.9 0.4 10.5 0.9 2.8 1 0 0 1 1 1 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) Staph_opine_DH PF10100.9 CDI87376.1 - 0.29 9.7 5.4 0.42 9.2 5.4 1.2 1 0 0 1 1 1 0 Staphylopine dehydrogenase DUF2838 PF10998.8 CDI87376.1 - 1.8 8.8 7.0 8.3 6.7 4.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2838) Ndc1_Nup PF09531.10 CDI87376.1 - 4.2 5.9 19.4 2.5 6.7 2.2 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup JmjC PF02373.22 CDI87377.1 - 1.8e-34 118.6 0.9 1.8e-34 118.6 0.9 3.4 3 0 0 3 3 3 1 JmjC domain, hydroxylase HEAT PF02985.22 CDI87378.1 - 0.79 10.2 3.3 4 8.0 0.0 4.2 3 0 0 3 3 3 0 HEAT repeat Condensation PF00668.20 CDI87379.1 - 0.049 12.3 0.3 1.7 7.3 0.0 3.2 4 0 0 4 4 4 0 Condensation domain OTCace_N PF02729.21 CDI87381.1 - 9.2e-28 97.1 0.3 9.2e-28 97.1 0.3 1.9 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain RLL PF10036.9 CDI87381.1 - 0.0009 19.2 0.8 0.0012 18.8 0.8 1.3 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein SPX PF03105.19 CDI87381.1 - 0.0071 16.3 4.4 0.0092 15.9 4.4 1.1 1 0 0 1 1 1 1 SPX domain Roughex PF06020.11 CDI87381.1 - 0.48 9.5 5.5 0.69 8.9 5.5 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Suf PF05843.14 CDI87381.1 - 0.72 9.8 7.5 0.22 11.5 2.9 2.0 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) MscS_TM PF12794.7 CDI87381.1 - 2.6 6.8 4.1 3.5 6.4 4.1 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 AF-4 PF05110.13 CDI87381.1 - 4.2 5.3 33.0 2 6.4 0.8 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein DUF4834 PF16118.5 CDI87381.1 - 9 7.3 10.8 6.7 7.7 5.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CCDC24 PF15669.5 CDI87381.1 - 9.6 6.0 15.3 17 5.2 0.3 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family Spt20 PF12090.8 CDI87385.1 - 3.8e-05 23.4 63.6 0.0031 17.2 21.6 2.3 2 0 0 2 2 2 2 Spt20 family RskA PF10099.9 CDI87385.1 - 4.3e-05 23.9 60.0 0.011 16.0 18.5 2.9 2 1 0 2 2 2 2 Anti-sigma-K factor rskA SARAF PF06682.12 CDI87385.1 - 0.00041 20.1 13.5 0.019 14.6 15.7 2.2 1 1 1 2 2 2 2 SOCE-associated regulatory factor of calcium homoeostasis PRP1_N PF06424.12 CDI87385.1 - 0.012 16.0 22.8 0.071 13.5 0.3 3.2 3 0 0 3 3 3 0 PRP1 splicing factor, N-terminal Spore_YhcN_YlaJ PF09580.10 CDI87385.1 - 0.03 14.4 0.0 0.03 14.4 0.0 2.9 2 1 0 2 2 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AP3D1 PF06375.11 CDI87385.1 - 0.53 10.5 0.0 0.53 10.5 0.0 3.1 2 1 1 3 3 3 0 AP-3 complex subunit delta-1 Hamartin PF04388.12 CDI87385.1 - 0.82 8.3 23.9 1 7.9 23.9 1.1 1 0 0 1 1 1 0 Hamartin protein DUF4834 PF16118.5 CDI87385.1 - 0.92 10.5 43.4 8 7.5 15.9 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) SDA1 PF05285.12 CDI87385.1 - 0.99 8.8 38.0 1.6 8.0 38.0 1.3 1 0 0 1 1 1 0 SDA1 Rad54_N PF08658.10 CDI87385.1 - 7.7 6.6 28.1 1.9 8.6 2.2 3.2 3 0 0 3 3 3 0 Rad54 N terminal G0-G1_switch_2 PF15103.6 CDI87385.1 - 8.9 6.8 29.4 7 7.1 1.8 3.3 3 0 0 3 3 3 0 G0/G1 switch protein 2 Baculo_PP31 PF05311.11 CDI87385.1 - 9.3 5.7 28.5 0.85 9.1 0.3 3.0 3 0 0 3 3 3 0 Baculovirus 33KDa late protein (PP31) SARAF PF06682.12 CDI87386.1 - 0.37 10.4 0.0 0.37 10.4 0.0 2.4 1 1 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Trp_oprn_chp PF09534.10 CDI87386.1 - 1 9.1 19.9 0.014 15.2 11.5 2.0 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Prok-RING_1 PF14446.6 CDI87387.1 - 0.00052 19.9 5.2 0.0012 18.7 5.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 GMC_oxred_C PF05199.13 CDI87387.1 - 0.0027 18.2 0.4 0.0027 18.2 0.4 3.2 3 2 1 4 4 4 1 GMC oxidoreductase DUF4598 PF15370.6 CDI87387.1 - 0.14 12.6 4.0 0.53 10.8 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4598) Apt1 PF10351.9 CDI87387.1 - 0.22 10.4 13.8 0.83 8.4 8.5 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain MACPF PF01823.19 CDI87387.1 - 4 7.5 13.0 4.6 7.3 0.4 2.1 2 0 0 2 2 2 0 MAC/Perforin domain Secretin_N_2 PF07655.13 CDI87387.1 - 4.4 7.9 42.2 1.4 9.5 20.2 2.8 3 0 0 3 3 3 0 Secretin N-terminal domain DDHD PF02862.17 CDI87388.1 - 0.002 18.3 1.9 0.002 18.3 1.9 5.2 2 1 0 2 2 2 1 DDHD domain DUF2207 PF09972.9 CDI87388.1 - 0.11 11.3 0.0 0.34 9.6 0.0 1.9 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) LptF_LptG PF03739.14 CDI87388.1 - 0.9 8.3 7.6 0.053 12.4 0.4 2.3 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG GWT1 PF06423.12 CDI87388.1 - 4.4 7.4 7.5 0.42 10.7 0.4 2.9 3 1 0 3 3 3 0 GWT1 SUIM_assoc PF16619.5 CDI87389.1 - 0.0014 18.6 3.4 0.018 15.1 1.9 5.7 4 1 1 5 5 5 3 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI87389.1 - 0.0017 18.0 63.6 0.018 14.7 16.5 4.2 4 0 0 4 4 4 3 Spt20 family Neur_chan_memb PF02932.16 CDI87389.1 - 1 9.4 12.9 0.77 9.8 1.6 2.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region TIP_N PF12457.8 CDI87389.1 - 8.8 6.8 10.5 5.8 7.4 1.9 3.1 2 0 0 2 2 2 0 Tuftelin interacting protein N terminal 5-FTHF_cyc-lig PF01812.20 CDI87390.1 - 2.4e-16 60.1 0.1 2.4e-11 43.8 0.1 2.4 2 0 0 2 2 2 2 5-formyltetrahydrofolate cyclo-ligase family RskA PF10099.9 CDI87390.1 - 6.5e-07 29.8 2.5 6.5e-07 29.8 2.5 3.1 2 1 1 3 3 3 2 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI87390.1 - 1.4e-06 28.1 6.4 1.4e-06 28.1 6.4 2.2 2 0 0 2 2 2 1 Spt20 family EPL1 PF10513.9 CDI87390.1 - 0.033 14.6 1.2 0.033 14.6 1.2 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like Rxt3 PF08642.10 CDI87390.1 - 0.11 13.3 2.0 0.2 12.4 0.4 2.1 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 DUF4834 PF16118.5 CDI87390.1 - 0.84 10.6 12.7 0.15 13.1 3.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) FKS1_dom1 PF14288.6 CDI87390.1 - 4.8 7.5 6.8 0.51 10.7 2.0 1.7 2 0 0 2 2 2 0 1,3-beta-glucan synthase subunit FKS1, domain-1 ANAPC_CDC26 PF10471.9 CDI87390.1 - 7.5 7.5 34.7 0.65 10.9 14.2 3.1 3 1 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 DivIC PF04977.15 CDI87390.1 - 9.1 6.1 22.0 1.7 8.4 9.1 2.3 2 0 0 2 2 2 0 Septum formation initiator TFIIA PF03153.13 CDI87390.1 - 9.1 6.2 40.9 0.12 12.3 14.5 2.3 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF773 PF05600.12 CDI87391.1 - 1e-35 123.5 27.3 1.2e-18 67.1 27.8 2.2 2 0 0 2 2 2 2 CDK5 regulatory subunit-associated protein 3 Plasmodium_Vir PF05795.11 CDI87391.1 - 0.00075 19.0 20.7 0.032 13.7 9.3 2.3 2 0 0 2 2 2 2 Plasmodium vivax Vir protein SPX PF03105.19 CDI87391.1 - 0.014 15.3 38.7 0.025 14.5 5.7 2.2 2 0 0 2 2 2 0 SPX domain RAP1 PF07218.11 CDI87391.1 - 0.042 12.1 26.1 0.047 12.0 13.3 2.2 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) HicB_lk_antitox PF15919.5 CDI87391.1 - 0.21 11.7 3.0 1.4 9.0 0.7 3.1 3 0 0 3 3 3 0 HicB_like antitoxin of bacterial toxin-antitoxin system SRP-alpha_N PF04086.13 CDI87391.1 - 0.26 11.2 28.5 0.41 10.5 18.1 2.2 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Utp14 PF04615.13 CDI87391.1 - 0.42 9.1 31.4 0.52 8.8 20.0 2.1 2 0 0 2 2 2 0 Utp14 protein MGC-24 PF05283.11 CDI87391.1 - 0.6 10.6 23.0 0.17 12.3 7.8 2.6 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin PPP4R2 PF09184.11 CDI87391.1 - 1.8 8.1 27.5 3 7.3 1.9 2.2 2 0 0 2 2 2 0 PPP4R2 tRNA-Thr_ED PF08915.11 CDI87391.1 - 1.8 8.6 7.1 0.35 10.9 1.7 2.4 2 0 0 2 2 2 0 Archaea-specific editing domain of threonyl-tRNA synthetase Herpes_pp85 PF04637.12 CDI87391.1 - 3.3 6.0 29.4 2.3 6.6 5.7 2.2 2 0 0 2 2 2 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Miga PF10265.9 CDI87391.1 - 4.5 6.1 47.8 0.38 9.7 15.5 2.6 1 1 0 2 2 2 0 Mitoguardin Activator_LAG-3 PF11498.8 CDI87392.1 - 0.011 14.8 22.0 0.011 14.7 22.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Tic110 PF16940.5 CDI87392.1 - 0.011 14.3 12.5 0.012 14.1 12.5 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF2232 PF09991.9 CDI87392.1 - 0.078 12.2 5.6 0.09 11.9 5.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) ALMT PF11744.8 CDI87392.1 - 0.35 9.6 7.9 0.35 9.7 7.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Spt20 PF12090.8 CDI87392.1 - 1.5 8.3 24.9 2.2 7.8 24.9 1.4 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI87392.1 - 1.7 8.5 33.4 1.9 8.4 33.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cyt_bd_oxida_I PF01654.17 CDI87392.1 - 2.8 6.5 12.0 3.1 6.3 12.0 1.0 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit I FAM199X PF15814.5 CDI87392.1 - 5.2 6.0 12.6 6.1 5.8 12.6 1.1 1 0 0 1 1 1 0 Protein family FAM199X DDHD PF02862.17 CDI87392.1 - 5.6 7.1 10.3 6.2 6.9 10.3 1.1 1 0 0 1 1 1 0 DDHD domain RskA PF10099.9 CDI87392.1 - 6.8 6.9 35.0 18 5.5 35.0 1.7 1 1 0 1 1 1 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI87393.1 - 1.4e-06 28.8 1.4 1.4e-06 28.8 1.4 3.5 1 1 1 2 2 1 1 Anti-sigma-K factor rskA MecA PF05389.12 CDI87393.1 - 0.00015 21.5 10.7 0.021 14.5 5.8 2.1 2 0 0 2 2 2 2 Negative regulator of genetic competence (MecA) SpoIIP PF07454.11 CDI87393.1 - 0.0002 20.9 14.7 0.019 14.4 8.6 2.2 2 0 0 2 2 2 2 Stage II sporulation protein P (SpoIIP) BTB_2 PF02214.22 CDI87393.1 - 0.00023 21.5 5.0 0.00059 20.1 0.6 2.6 2 1 0 2 2 1 1 BTB/POZ domain DUF4050 PF13259.6 CDI87393.1 - 0.0041 17.5 9.8 0.12 12.6 5.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF4050) Eapp_C PF10238.9 CDI87393.1 - 0.0045 17.1 18.4 0.0048 17.0 5.8 2.4 2 0 0 2 2 2 1 E2F-associated phosphoprotein MCU PF04678.13 CDI87393.1 - 0.0089 16.1 16.5 0.042 13.9 0.6 2.3 2 0 0 2 2 2 1 Mitochondrial calcium uniporter FAM60A PF15396.6 CDI87393.1 - 0.0093 16.0 10.9 0.5 10.3 7.4 2.2 2 0 0 2 2 2 1 Protein Family FAM60A SLC12 PF03522.15 CDI87393.1 - 0.015 14.3 16.0 0.013 14.5 6.3 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Dynamin_N PF00350.23 CDI87393.1 - 0.017 15.2 3.4 0.017 15.2 3.4 2.2 2 0 0 2 2 2 0 Dynamin family DUF533 PF04391.12 CDI87393.1 - 0.022 14.3 0.9 0.022 14.3 0.9 3.7 2 2 0 2 2 1 0 Protein of unknown function (DUF533) eIF-3_zeta PF05091.12 CDI87393.1 - 0.039 12.9 29.7 0.1 11.6 16.1 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EphA2_TM PF14575.6 CDI87393.1 - 0.042 14.7 4.0 0.042 14.7 4.0 3.4 2 1 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Peroxin-13_N PF04088.13 CDI87393.1 - 0.044 14.1 13.5 0.44 10.8 7.1 2.4 2 0 0 2 2 2 0 Peroxin 13, N-terminal region BORG_CEP PF14957.6 CDI87393.1 - 0.056 14.6 10.4 0.21 12.7 3.8 2.3 2 0 0 2 2 2 0 Cdc42 effector CCDC53 PF10152.9 CDI87393.1 - 0.063 13.7 25.3 0.052 14.0 10.7 2.5 3 0 0 3 3 2 0 Subunit CCDC53 of WASH complex DUF4484 PF14831.6 CDI87393.1 - 0.078 13.0 15.3 0.11 12.5 6.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) NinG PF05766.12 CDI87393.1 - 0.11 12.4 21.1 1.2 9.0 10.4 2.4 2 0 0 2 2 2 0 Bacteriophage Lambda NinG protein Suf PF05843.14 CDI87393.1 - 0.12 12.3 36.3 0.02 14.9 14.8 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) CLN3 PF02487.17 CDI87393.1 - 0.14 11.2 13.3 0.066 12.3 3.8 2.1 2 0 0 2 2 2 0 CLN3 protein CPSF100_C PF13299.6 CDI87393.1 - 0.14 12.3 18.1 0.055 13.6 6.3 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 CDI87393.1 - 0.15 11.8 15.2 0.074 12.8 5.1 2.1 2 0 0 2 2 2 0 Connexin Pet20 PF08692.10 CDI87393.1 - 0.16 12.7 10.5 1.9 9.2 2.5 2.4 2 0 0 2 2 2 0 Mitochondrial protein Pet20 DUF5523 PF17661.1 CDI87393.1 - 0.16 11.6 20.1 0.27 10.9 9.9 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Rxt3 PF08642.10 CDI87393.1 - 0.16 12.7 12.4 0.46 11.3 3.2 2.4 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 FAM176 PF14851.6 CDI87393.1 - 0.23 11.1 10.9 0.56 9.9 4.5 2.2 2 0 0 2 2 2 0 FAM176 family Afi1 PF07792.12 CDI87393.1 - 0.23 12.0 18.4 0.095 13.2 6.1 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Apc15p PF05841.11 CDI87393.1 - 0.28 12.0 29.9 0.067 14.0 9.9 2.7 3 0 0 3 3 2 0 Apc15p protein DUF3347 PF11827.8 CDI87393.1 - 0.29 11.3 20.7 0.11 12.7 8.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) GNAT_acetyltr_2 PF13718.6 CDI87393.1 - 0.32 10.4 15.3 0.065 12.6 4.1 2.3 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Orf78 PF06024.12 CDI87393.1 - 0.35 11.2 14.0 0.23 11.8 3.7 2.5 2 0 0 2 2 2 0 Orf78 (ac78) Rad54_N PF08658.10 CDI87393.1 - 0.35 11.0 10.7 3.5 7.7 0.3 2.3 2 0 0 2 2 2 0 Rad54 N terminal DUF2126 PF09899.9 CDI87393.1 - 0.41 8.7 16.2 0.1 10.7 7.2 2.0 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) Serinc PF03348.15 CDI87393.1 - 0.42 9.5 10.8 3.4 6.5 7.1 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) GvpL_GvpF PF06386.11 CDI87393.1 - 0.55 10.1 23.5 0.88 9.5 12.2 2.4 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF OATP PF03137.20 CDI87393.1 - 0.56 8.4 11.2 0.16 10.3 2.5 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Ndc1_Nup PF09531.10 CDI87393.1 - 0.58 8.8 21.2 0.13 11.0 17.8 1.6 1 1 1 2 2 2 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 CDI87393.1 - 0.66 8.2 42.7 0.051 11.8 21.7 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF3402 PF11882.8 CDI87393.1 - 0.67 9.0 21.6 0.011 14.8 6.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3402) GOLD_2 PF13897.6 CDI87393.1 - 0.77 10.3 5.5 0.36 11.3 0.7 2.1 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking HGTP_anticodon2 PF12745.7 CDI87393.1 - 0.82 9.1 19.9 0.077 12.5 5.4 2.3 2 0 0 2 2 2 0 Anticodon binding domain of tRNAs Nha1_C PF08619.10 CDI87393.1 - 0.91 8.7 20.2 0.026 13.8 6.8 2.1 2 0 0 2 2 2 0 Alkali metal cation/H+ antiporter Nha1 C terminus SPG4 PF17325.2 CDI87393.1 - 0.92 10.6 15.1 0.47 11.5 4.6 2.4 2 0 0 2 2 2 0 Stationary phase protein 4 RMP PF14996.6 CDI87393.1 - 0.94 9.7 18.1 0.27 11.5 6.0 2.3 2 0 0 2 2 2 0 Retinal Maintenance Dala_Dala_lig_N PF01820.21 CDI87393.1 - 1 9.9 5.6 10 6.7 1.9 2.4 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus TCP PF03634.13 CDI87393.1 - 1.1 9.8 23.9 0.55 10.8 0.2 2.4 2 1 0 2 2 2 0 TCP family transcription factor Lin-8 PF03353.15 CDI87393.1 - 1.2 8.6 25.3 0.07 12.7 9.2 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist dsRBD2 PF17842.1 CDI87393.1 - 1.3 9.3 14.9 3.4 7.8 8.0 2.3 2 0 0 2 2 2 0 Double-stranded RNA binding domain 2 DUF4471 PF14740.6 CDI87393.1 - 1.4 8.0 17.1 0.19 10.9 6.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) PPL5 PF18168.1 CDI87393.1 - 1.5 8.1 12.1 0.095 12.0 2.3 2.2 2 0 0 2 2 2 0 Prim-pol family 5 V_ATPase_I PF01496.19 CDI87393.1 - 1.5 6.7 24.3 0.13 10.2 11.5 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family PRC2_HTH_1 PF18118.1 CDI87393.1 - 1.5 9.7 17.0 0.44 11.4 5.4 2.4 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain RR_TM4-6 PF06459.12 CDI87393.1 - 1.5 8.5 23.0 0.16 11.8 8.6 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Acatn PF13000.7 CDI87393.1 - 1.6 7.1 6.8 0.49 8.8 1.3 1.9 2 0 0 2 2 2 0 Acetyl-coenzyme A transporter 1 ABC2_membrane_2 PF12679.7 CDI87393.1 - 1.7 7.8 18.4 0.015 14.6 3.0 2.3 2 0 0 2 2 2 0 ABC-2 family transporter protein ORC5_C PF14630.6 CDI87393.1 - 1.9 7.9 14.3 3.2 7.2 6.4 2.2 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus CobT PF06213.12 CDI87393.1 - 2 7.7 35.9 0.13 11.7 16.3 2.4 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF4820 PF16091.5 CDI87393.1 - 2.4 7.4 19.2 3.2 7.0 9.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Tim54 PF11711.8 CDI87393.1 - 2.5 6.8 20.2 1.3 7.7 9.0 2.6 3 0 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 DUF2370 PF10176.9 CDI87393.1 - 2.8 7.5 8.2 0.56 9.8 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) YABBY PF04690.13 CDI87393.1 - 2.8 8.5 21.7 5 7.7 10.0 2.3 2 0 0 2 2 2 0 YABBY protein Folate_carrier PF01770.18 CDI87393.1 - 2.9 6.5 12.3 0.74 8.5 3.7 2.1 2 0 0 2 2 2 0 Reduced folate carrier DUF1266 PF06889.11 CDI87393.1 - 3 7.9 15.1 0.39 10.8 2.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) DUF4045 PF13254.6 CDI87393.1 - 3.2 7.3 17.5 0.14 11.7 6.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) Maf1 PF09174.10 CDI87393.1 - 3.4 7.8 14.7 3.4 7.8 4.3 2.3 2 0 0 2 2 2 0 Maf1 regulator CCSAP PF15748.5 CDI87393.1 - 3.8 7.6 25.1 0.74 9.9 12.0 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DUF4628 PF15429.6 CDI87393.1 - 4.1 7.0 23.0 3.9 7.1 10.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4628) EIF4E-T PF10477.9 CDI87393.1 - 4.2 6.1 44.2 0.31 9.8 7.0 2.1 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E CTU2 PF10288.9 CDI87393.1 - 4.2 7.6 31.0 0.061 13.6 0.9 2.3 2 1 0 2 2 1 0 Cytoplasmic tRNA 2-thiolation protein 2 MCD PF05292.11 CDI87393.1 - 4.2 6.8 14.3 0.27 10.8 4.3 2.2 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase C-terminal domain PH_4 PF15404.6 CDI87393.1 - 4.7 7.0 16.7 0.84 9.4 5.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain PA26 PF04636.13 CDI87393.1 - 5.4 5.8 18.7 1 8.2 8.0 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) MMU163 PF17119.5 CDI87393.1 - 6.1 5.9 10.1 1 8.5 2.4 2.2 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis TUSC2 PF15000.6 CDI87393.1 - 6.3 7.1 13.7 7.2 6.9 1.3 2.6 2 0 0 2 2 2 0 Tumour suppressor candidate 2 LRR19-TM PF15176.6 CDI87393.1 - 6.8 6.8 6.5 1 9.4 0.9 2.1 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain Trypan_glycop_C PF10659.9 CDI87393.1 - 9 6.7 17.7 22 5.5 8.8 2.9 2 0 0 2 2 2 0 Trypanosome variant surface glycoprotein C-terminal domain Scs3p PF10261.9 CDI87393.1 - 9.5 5.6 9.9 1.8 8.0 1.7 2.2 2 0 0 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM Peptidase_S49_N PF08496.10 CDI87393.1 - 9.9 6.2 27.6 11 6.1 15.1 2.4 2 1 0 2 2 2 0 Peptidase family S49 N-terminal Exo_endo_phos PF03372.23 CDI87395.1 - 5.9e-17 62.0 1.6 6.2e-11 42.3 0.1 2.1 2 0 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family DUF3168 PF11367.8 CDI87395.1 - 0.072 13.3 0.4 0.2 11.9 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3168) Exo_endo_phos_2 PF14529.6 CDI87395.1 - 0.085 12.7 0.0 13 5.6 0.0 2.8 3 0 0 3 3 3 0 Endonuclease-reverse transcriptase TFIIS_C PF01096.18 CDI87396.1 - 6.2e-14 51.6 5.0 6.2e-14 51.6 5.0 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Zn-ribbon_8 PF09723.10 CDI87396.1 - 0.012 15.8 11.2 0.95 9.6 0.0 4.4 3 1 0 3 3 3 0 Zinc ribbon domain DNA_RNApol_7kD PF03604.13 CDI87396.1 - 0.23 11.2 0.1 0.23 11.2 0.1 4.2 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_4 PF13717.6 CDI87396.1 - 0.65 10.0 11.6 0.95 9.4 0.1 4.0 4 0 0 4 4 4 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 CDI87396.1 - 0.98 9.5 6.3 17 5.5 4.2 2.9 2 0 0 2 2 2 0 Transposase zinc-ribbon domain HypA PF01155.19 CDI87396.1 - 3.4 7.7 9.7 3.5e+02 1.2 9.5 2.9 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2757 PF10955.8 CDI87396.1 - 5.6 7.3 9.0 23 5.3 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2757) FAM176 PF14851.6 CDI87397.1 - 0.015 15.0 9.7 0.019 14.7 9.7 1.1 1 0 0 1 1 1 0 FAM176 family Afi1 PF07792.12 CDI87397.1 - 0.047 14.2 16.4 0.051 14.1 16.4 1.0 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Presenilin PF01080.17 CDI87397.1 - 0.06 12.1 21.1 0.06 12.1 21.1 1.0 1 0 0 1 1 1 0 Presenilin CobT PF06213.12 CDI87397.1 - 0.14 11.5 27.3 0.16 11.3 27.3 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SpoIIP PF07454.11 CDI87397.1 - 0.23 10.9 21.0 0.24 10.8 21.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PIP5K PF01504.18 CDI87397.1 - 0.28 10.3 16.0 0.31 10.2 16.0 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase TRAP_alpha PF03896.16 CDI87397.1 - 0.31 10.2 8.5 0.35 10.0 8.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Connexin PF00029.19 CDI87397.1 - 0.34 10.6 15.5 0.38 10.5 15.5 1.0 1 0 0 1 1 1 0 Connexin SelP_N PF04592.14 CDI87397.1 - 0.36 10.2 21.5 0.41 10.0 21.5 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region V_ATPase_I PF01496.19 CDI87397.1 - 0.36 8.7 23.1 0.4 8.5 23.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4366 PF14283.6 CDI87397.1 - 0.46 10.5 9.5 0.52 10.3 9.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) CLN3 PF02487.17 CDI87397.1 - 0.46 9.5 15.9 0.5 9.4 15.9 1.0 1 0 0 1 1 1 0 CLN3 protein Tim54 PF11711.8 CDI87397.1 - 0.51 9.1 17.8 0.56 8.9 17.8 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SID-1_RNA_chan PF13965.6 CDI87397.1 - 0.53 8.6 9.6 0.54 8.6 9.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF5308 PF17233.2 CDI87397.1 - 0.54 10.5 16.2 0.58 10.4 16.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF4628 PF15429.6 CDI87397.1 - 0.55 9.9 15.7 0.59 9.8 15.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) NPR3 PF03666.13 CDI87397.1 - 0.6 8.8 19.5 0.65 8.7 19.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Scs3p PF10261.9 CDI87397.1 - 0.64 9.5 7.6 0.67 9.4 7.6 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF2828 PF11443.8 CDI87397.1 - 0.67 8.0 19.7 0.75 7.8 19.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF913 PF06025.12 CDI87397.1 - 0.68 8.9 12.5 0.68 8.8 12.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) OATP PF03137.20 CDI87397.1 - 0.74 8.0 10.1 0.74 8.0 10.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SLC12 PF03522.15 CDI87397.1 - 0.74 8.8 20.0 0.83 8.6 20.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CPSF100_C PF13299.6 CDI87397.1 - 0.76 9.9 16.2 0.9 9.7 16.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Pap_E4 PF02711.14 CDI87397.1 - 0.84 10.6 19.4 1.1 10.3 19.4 1.1 1 0 0 1 1 1 0 E4 protein RR_TM4-6 PF06459.12 CDI87397.1 - 0.99 9.2 21.3 1.1 9.0 21.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1764 PF08576.10 CDI87397.1 - 1 10.3 17.6 1.3 10.0 17.6 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Neur_chan_memb PF02932.16 CDI87397.1 - 1.2 9.2 16.3 1.3 9.0 16.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_U57 PF05582.12 CDI87397.1 - 1.2 8.4 13.1 1.2 8.3 13.1 1.0 1 0 0 1 1 1 0 YabG peptidase U57 PRC2_HTH_1 PF18118.1 CDI87397.1 - 1.2 10.0 13.1 1.7 9.5 13.1 1.3 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Gti1_Pac2 PF09729.9 CDI87397.1 - 1.2 9.2 17.2 1.3 9.0 17.2 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family EPL1 PF10513.9 CDI87397.1 - 1.2 9.5 22.9 1.4 9.3 22.9 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like ALMT PF11744.8 CDI87397.1 - 1.3 7.8 17.0 1.4 7.7 17.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter MMU163 PF17119.5 CDI87397.1 - 1.3 8.2 12.4 1.5 7.9 12.4 1.0 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Zip PF02535.22 CDI87397.1 - 1.3 8.2 12.2 1.3 8.1 12.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CSG2 PF16965.5 CDI87397.1 - 1.3 7.9 11.9 1.3 7.9 11.9 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator NARP1 PF12569.8 CDI87397.1 - 1.3 7.8 19.8 1.5 7.7 19.8 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CCDC53 PF10152.9 CDI87397.1 - 1.4 9.3 22.0 1.6 9.1 22.0 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex AIF_C PF14721.6 CDI87397.1 - 1.5 9.2 15.8 1.8 8.9 15.8 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term MRI PF15325.6 CDI87397.1 - 1.7 9.8 7.8 2.7 9.1 7.8 1.3 1 1 0 1 1 1 0 Modulator of retrovirus infection YABBY PF04690.13 CDI87397.1 - 1.7 9.2 17.8 1.9 9.0 17.8 1.0 1 0 0 1 1 1 0 YABBY protein DUF4746 PF15928.5 CDI87397.1 - 1.7 8.0 16.2 2 7.8 16.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) F-protein PF00469.20 CDI87397.1 - 2.2 7.8 16.2 2.2 7.8 16.2 1.0 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef DUF3408 PF11888.8 CDI87397.1 - 2.2 8.4 20.0 2.9 8.0 20.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Ureide_permease PF07168.11 CDI87397.1 - 2.2 6.9 10.7 2.4 6.8 10.7 1.0 1 0 0 1 1 1 0 Ureide permease Rtf2 PF04641.12 CDI87397.1 - 2.2 7.6 17.9 2.5 7.4 17.9 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger CDC45 PF02724.14 CDI87397.1 - 2.2 6.5 16.7 2.5 6.3 16.7 1.0 1 0 0 1 1 1 0 CDC45-like protein RP-C_C PF11800.8 CDI87397.1 - 2.3 8.3 18.0 2.4 8.2 18.0 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region Kei1 PF08552.11 CDI87397.1 - 2.4 8.0 14.9 2.6 7.9 14.9 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DDHD PF02862.17 CDI87397.1 - 2.4 8.2 18.6 2.8 8.0 18.6 1.1 1 0 0 1 1 1 0 DDHD domain Paf1 PF03985.13 CDI87397.1 - 2.5 7.0 23.8 2.9 6.8 23.8 1.0 1 0 0 1 1 1 0 Paf1 PTPRCAP PF15713.5 CDI87397.1 - 2.6 8.3 21.7 3.1 8.1 21.7 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated BORG_CEP PF14957.6 CDI87397.1 - 2.6 9.2 14.3 3 9.0 14.3 1.1 1 0 0 1 1 1 0 Cdc42 effector Folate_carrier PF01770.18 CDI87397.1 - 2.6 6.7 11.5 2.8 6.6 11.5 1.1 1 0 0 1 1 1 0 Reduced folate carrier FAM60A PF15396.6 CDI87397.1 - 2.7 7.9 15.6 3 7.8 15.6 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF2126 PF09899.9 CDI87397.1 - 3.4 5.6 17.8 3.9 5.4 17.8 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) eIF-3_zeta PF05091.12 CDI87397.1 - 3.8 6.4 27.1 4 6.3 27.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4638 PF15472.6 CDI87397.1 - 4 7.1 19.1 4.4 7.0 19.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Endostatin PF06482.11 CDI87397.1 - 4.5 6.7 20.9 4.5 6.6 20.9 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Ketoacyl-synt_2 PF13723.6 CDI87397.1 - 4.5 6.8 23.1 5.7 6.5 23.1 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain CBP_BcsG PF11658.8 CDI87397.1 - 4.8 5.5 17.1 5.1 5.4 17.1 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DUF1180 PF06679.12 CDI87397.1 - 4.9 7.5 8.4 5.5 7.4 8.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Pex14_N PF04695.13 CDI87397.1 - 5.1 7.7 33.2 5.9 7.5 33.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFB6 PF17110.5 CDI87397.1 - 5.1 6.8 12.0 6.8 6.4 12.0 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH T2SSC PF11356.8 CDI87397.1 - 5.5 6.9 15.5 6.2 6.7 15.5 1.1 1 0 0 1 1 1 0 Type II secretion system protein C Pannexin_like PF12534.8 CDI87397.1 - 5.6 6.0 15.3 6.2 5.8 15.3 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 PPL5 PF18168.1 CDI87397.1 - 5.6 6.2 15.9 6.3 6.0 15.9 1.0 1 0 0 1 1 1 0 Prim-pol family 5 PepSY_TM PF03929.16 CDI87397.1 - 5.8 6.5 13.5 6.6 6.3 13.5 1.2 1 0 0 1 1 1 0 PepSY-associated TM region CPSF73-100_C PF11718.8 CDI87397.1 - 5.8 6.4 15.3 14 5.2 15.3 1.6 1 1 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Peptidase_S64 PF08192.11 CDI87397.1 - 6 5.2 17.9 6.8 5.1 17.9 1.0 1 0 0 1 1 1 0 Peptidase family S64 Band_3_cyto PF07565.13 CDI87397.1 - 6 6.6 20.8 6.5 6.5 20.8 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PAT1 PF09770.9 CDI87397.1 - 6.5 4.9 35.6 7.3 4.7 35.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Serinc PF03348.15 CDI87397.1 - 7.2 5.4 13.8 7.8 5.3 13.8 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Suf PF05843.14 CDI87397.1 - 8.7 6.2 26.6 13 5.7 26.6 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Membralin PF09746.9 CDI87397.1 - 9 5.2 14.9 10 5.1 14.9 1.0 1 0 0 1 1 1 0 Tumour-associated protein Pet20 PF08692.10 CDI87397.1 - 9.1 7.0 10.9 12 6.6 10.9 1.3 1 0 0 1 1 1 0 Mitochondrial protein Pet20 Velvet PF11754.8 CDI87397.1 - 9.2 6.1 21.2 10 6.0 21.2 1.0 1 0 0 1 1 1 0 Velvet factor UPF0560 PF10577.9 CDI87397.1 - 9.5 4.6 33.2 10 4.5 33.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF2464 PF10240.9 CDI87397.1 - 9.5 5.7 14.9 11 5.5 14.9 1.0 1 0 0 1 1 1 0 Multivesicular body subunit 12 Sec62 PF03839.16 CDI87397.1 - 9.7 5.6 18.4 11 5.4 18.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4471 PF14740.6 CDI87397.1 - 9.7 5.3 17.2 12 5.0 17.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) Spt20 PF12090.8 CDI87398.1 - 0.0012 18.6 27.5 0.0012 18.6 27.5 13.0 12 1 0 12 12 12 8 Spt20 family RskA PF10099.9 CDI87398.1 - 0.0013 19.1 3.4 0.0013 19.1 3.4 12.9 5 3 3 11 11 11 3 Anti-sigma-K factor rskA Pex14_N PF04695.13 CDI87398.1 - 0.0014 19.3 9.2 0.0014 19.3 9.2 13.8 8 6 2 11 11 11 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2722 PF10846.8 CDI87398.1 - 0.0016 17.5 7.2 0.0016 17.5 7.2 12.8 11 2 2 13 13 13 4 Protein of unknown function (DUF2722) HNOBA PF07701.14 CDI87398.1 - 0.0049 16.3 0.1 0.0049 16.3 0.1 9.0 6 3 1 7 7 7 2 Heme NO binding associated DUF3740 PF12548.8 CDI87398.1 - 0.046 14.2 0.2 0.046 14.2 0.2 10.4 10 1 1 11 11 11 0 Sulfatase protein IER PF05760.12 CDI87399.1 - 0.099 12.9 11.3 0.12 12.7 11.3 1.1 1 0 0 1 1 1 0 Immediate early response protein (IER) SUIM_assoc PF16619.5 CDI87399.1 - 0.12 12.4 34.7 0.22 11.6 10.2 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Zip PF02535.22 CDI87399.1 - 0.16 11.1 5.7 0.18 11.0 5.7 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2489 PF10675.9 CDI87399.1 - 0.63 10.0 16.0 0.14 12.0 4.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) TFIIA PF03153.13 CDI87399.1 - 0.73 9.8 28.7 0.88 9.5 28.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 CDI87399.1 - 1.7 7.6 8.2 1.9 7.5 8.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Phostensin_N PF13916.6 CDI87399.1 - 2.3 8.6 15.3 0.65 10.4 1.5 2.3 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal Lin-8 PF03353.15 CDI87399.1 - 2.8 7.4 12.8 3.4 7.1 12.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist V_ATPase_I PF01496.19 CDI87399.1 - 3.6 5.4 7.7 4.1 5.2 7.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CCDC117 PF15810.5 CDI87399.1 - 3.8 7.8 15.4 1.1 9.6 4.6 2.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 117 PAT1 PF09770.9 CDI87399.1 - 5.4 5.2 19.7 6.2 5.0 19.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peroxin-3 PF04882.12 CDI87399.1 - 6.3 5.7 12.6 7.6 5.4 12.6 1.0 1 0 0 1 1 1 0 Peroxin-3 Presenilin PF01080.17 CDI87399.1 - 6.6 5.4 11.7 7.4 5.2 11.7 1.1 1 0 0 1 1 1 0 Presenilin NST1 PF13945.6 CDI87399.1 - 7 6.7 16.1 10 6.2 16.1 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Hep_59 PF07052.11 CDI87399.1 - 8 7.3 17.8 3.1e+02 2.2 17.8 2.1 1 1 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 Hid1 PF12722.7 CDI87399.1 - 8.6 4.3 10.2 9.5 4.2 10.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ALMT PF11744.8 CDI87399.1 - 9.5 4.9 6.3 10 4.8 6.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Kinesin PF00225.23 CDI87401.1 - 2.4e-100 335.7 0.0 4.1e-100 334.9 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDI87401.1 - 1.4e-20 73.7 0.1 4.1e-20 72.2 0.1 1.8 1 1 0 1 1 1 1 Microtubule binding KIF1B PF12423.8 CDI87401.1 - 7.4e-05 23.1 0.0 0.00032 21.1 0.0 2.2 2 0 0 2 2 2 1 Kinesin protein 1B Kinesin_assoc PF16183.5 CDI87401.1 - 0.002 18.3 16.4 0.013 15.7 1.0 3.9 3 1 1 4 4 4 2 Kinesin-associated PKD_channel PF08016.12 CDI87402.1 - 0.00048 18.9 10.4 0.00048 18.9 10.4 4.5 4 1 1 5 5 5 3 Polycystin cation channel FAM184 PF15665.5 CDI87402.1 - 9.9 5.9 13.2 9.9 5.9 3.6 2.5 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B AMP-binding PF00501.28 CDI87403.1 - 2.6e-08 32.9 0.0 1.8e-07 30.1 0.0 2.0 1 1 0 1 1 1 1 AMP-binding enzyme zf-C2H2_2 PF12756.7 CDI87404.1 - 8e-13 48.6 9.7 7.8e-11 42.2 1.8 4.0 4 0 0 4 4 4 2 C2H2 type zinc-finger (2 copies) DUF3449 PF11931.8 CDI87404.1 - 0.24 11.2 0.0 0.24 11.2 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3449) Mito_carr PF00153.27 CDI87405.1 - 1.2e-58 195.1 3.2 1.6e-22 79.2 0.0 4.4 4 0 0 4 4 4 4 Mitochondrial carrier protein DUF45 PF01863.17 CDI87408.1 - 0.00024 21.2 0.0 0.00024 21.2 0.0 3.2 4 1 0 4 4 4 1 Protein of unknown function DUF45 WLM PF08325.10 CDI87408.1 - 0.046 13.8 0.2 0.046 13.8 0.2 3.5 3 1 0 3 3 3 0 WLM domain TCO89 PF10452.9 CDI87410.1 - 0.013 14.5 1.1 0.021 13.8 1.1 1.2 1 0 0 1 1 1 0 TORC1 subunit TCO89 Epiglycanin_C PF14654.6 CDI87410.1 - 0.049 13.7 0.3 0.12 12.4 0.3 1.6 1 0 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region Mago-bind PF09282.10 CDI87410.1 - 0.51 10.3 2.3 19 5.2 0.4 2.4 2 0 0 2 2 2 0 Mago binding PAM2 PF07145.15 CDI87411.1 - 0.0023 17.5 0.5 0.006 16.2 0.5 1.7 1 0 0 1 1 1 1 Ataxin-2 C-terminal region CNDH2_M PF16869.5 CDI87411.1 - 1.3 9.7 9.7 4 8.1 1.2 2.7 2 0 0 2 2 2 0 PF16858 TFIIA PF03153.13 CDI87411.1 - 1.7 8.5 35.0 1.4 8.8 18.5 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DNA_pol_B PF00136.21 CDI87412.1 - 3.7e-76 256.7 0.0 9.9e-76 255.3 0.0 1.8 1 1 0 1 1 1 1 DNA polymerase family B zf-C4pol PF14260.6 CDI87412.1 - 1.5e-05 25.4 9.1 1.5e-05 25.4 9.1 4.5 4 1 0 4 4 4 1 C4-type zinc-finger of DNA polymerase delta DMAP1 PF05499.12 CDI87412.1 - 0.05 13.5 2.8 0.23 11.4 2.8 2.2 1 0 0 1 1 1 0 DNA methyltransferase 1-associated protein 1 (DMAP1) DUF1590 PF07629.11 CDI87413.1 - 0.01 15.6 0.3 2.3 8.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1590) PhyH PF05721.13 CDI87415.1 - 1.6e-10 41.6 0.1 3e-09 37.5 0.0 2.9 2 1 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) TauD PF02668.16 CDI87415.1 - 0.0056 16.5 0.0 0.026 14.3 0.0 2.0 2 1 1 3 3 3 1 Taurine catabolism dioxygenase TauD, TfdA family Peptidase_C2 PF00648.21 CDI87417.1 - 4e-32 111.4 0.1 1e-30 106.8 0.0 2.6 1 1 1 2 2 2 2 Calpain family cysteine protease AP2 PF00847.20 CDI87418.1 - 1.7e-16 60.2 3.3 2.9e-12 46.6 0.1 2.5 2 0 0 2 2 2 2 AP2 domain ACDC PF14733.6 CDI87418.1 - 0.0018 18.6 0.0 0.0046 17.2 0.0 1.7 1 0 0 1 1 1 1 AP2-coincident C-terminal FtsJ PF01728.19 CDI87419.1 - 5.9e-54 182.8 0.0 7.7e-54 182.5 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 CDI87419.1 - 0.00096 19.0 0.1 0.024 14.4 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI87419.1 - 0.0099 15.7 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NSP16 PF06460.12 CDI87419.1 - 0.026 13.7 0.0 0.033 13.3 0.0 1.2 1 0 0 1 1 1 0 Coronavirus NSP16 2Fe-2S_Ferredox PF11591.8 CDI87419.1 - 0.53 10.2 3.0 0.34 10.8 0.3 2.1 3 0 0 3 3 3 0 Ferredoxin chloroplastic transit peptide NUDIX_2 PF13869.6 CDI87420.1 - 7.7e-55 185.4 0.0 1e-54 185.0 0.0 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase WD40 PF00400.32 CDI87421.1 - 1.3e-07 32.1 15.4 11 7.1 0.0 10.9 10 1 0 10 10 10 4 WD domain, G-beta repeat EBP50_C PF09007.11 CDI87422.1 - 0.0022 19.0 31.6 0.052 14.5 6.7 3.2 3 0 0 3 3 3 2 EBP50, C-terminal Myc_N PF01056.18 CDI87422.1 - 0.0075 16.2 0.6 0.0075 16.2 0.6 3.1 3 0 0 3 3 3 1 Myc amino-terminal region AAA_23 PF13476.6 CDI87422.1 - 0.013 16.0 14.5 0.013 16.0 14.5 2.4 2 1 0 2 2 1 0 AAA domain SR-25 PF10500.9 CDI87422.1 - 0.015 14.9 14.1 0.015 14.9 14.1 4.1 3 1 1 4 4 4 0 Nuclear RNA-splicing-associated protein BSP_II PF05432.11 CDI87422.1 - 0.066 12.9 38.1 0.65 9.6 13.7 2.1 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Caldesmon PF02029.15 CDI87422.1 - 0.2 10.4 34.9 0.71 8.6 21.8 2.1 2 0 0 2 2 2 0 Caldesmon DUF3408 PF11888.8 CDI87422.1 - 0.28 11.3 23.2 1.3 9.1 4.5 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3408) Mpp10 PF04006.12 CDI87422.1 - 0.4 9.1 38.9 0.21 10.0 17.1 2.1 2 0 0 2 2 2 0 Mpp10 protein SART-1 PF03343.13 CDI87422.1 - 0.86 8.1 28.0 0.029 12.9 13.3 2.1 2 0 0 2 2 2 0 SART-1 family TFB6 PF17110.5 CDI87422.1 - 0.89 9.3 20.8 0.12 12.1 3.8 3.1 3 0 0 3 3 3 0 Subunit 11 of the general transcription factor TFIIH CCDC106 PF15794.5 CDI87422.1 - 1.7 8.3 38.8 1.2 8.8 7.6 3.2 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 106 Secretin_N_2 PF07655.13 CDI87422.1 - 1.7 9.2 44.2 1 9.9 21.7 3.3 3 0 0 3 3 3 0 Secretin N-terminal domain XAP5 PF04921.14 CDI87422.1 - 1.8 8.3 32.9 0.54 10.0 4.7 3.1 2 1 1 3 3 3 0 XAP5, circadian clock regulator PPP4R2 PF09184.11 CDI87422.1 - 3.1 7.3 34.3 0.3 10.6 15.5 2.4 2 0 0 2 2 2 0 PPP4R2 EIIBC-GUT_N PF03612.14 CDI87422.1 - 4 7.2 23.0 0.12 12.1 5.2 3.0 3 0 0 3 3 3 0 Sorbitol phosphotransferase enzyme II N-terminus RNA_pol_Rpc4 PF05132.14 CDI87422.1 - 5.8 7.3 26.0 1.6 9.2 1.5 3.2 3 0 0 3 3 3 0 RNA polymerase III RPC4 TRAP_alpha PF03896.16 CDI87422.1 - 8.7 5.5 18.9 4.4 6.4 2.3 2.9 3 0 0 3 3 3 0 Translocon-associated protein (TRAP), alpha subunit DUF572 PF04502.13 CDI87423.1 - 0.34 10.5 4.8 0.63 9.6 4.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) Neur_chan_memb PF02932.16 CDI87423.1 - 0.35 10.9 3.6 0.69 9.9 3.6 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4834 PF16118.5 CDI87423.1 - 0.66 11.0 4.6 0.78 10.7 2.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ndc1_Nup PF09531.10 CDI87423.1 - 0.97 8.0 11.7 1.5 7.4 11.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CDK5_activator PF03261.15 CDI87423.1 - 1.1 8.8 5.9 1.6 8.2 5.9 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Suf PF05843.14 CDI87423.1 - 2.8 7.8 10.3 9.2 6.1 10.3 1.9 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RAB3GAP2_N PF14655.6 CDI87423.1 - 3.7 6.7 9.2 0.3 10.3 3.6 1.9 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus RskA PF10099.9 CDI87423.1 - 5.6 7.2 52.6 0.074 13.3 27.6 3.2 2 1 1 3 3 3 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI87425.1 - 2.3e-08 34.5 19.0 1.3e-06 28.9 0.2 6.0 1 1 4 5 5 5 3 Anti-sigma-K factor rskA PAP2 PF01569.21 CDI87425.1 - 0.0031 17.3 0.5 0.25 11.1 0.1 3.0 2 0 0 2 2 2 1 PAP2 superfamily Peptidase_S49_N PF08496.10 CDI87425.1 - 0.82 9.7 40.4 5.3 7.1 0.1 5.3 5 0 0 5 5 5 0 Peptidase family S49 N-terminal DUF2722 PF10846.8 CDI87426.1 - 3.2e-06 26.4 9.0 4.9e-06 25.8 9.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI87426.1 - 0.00074 19.8 4.3 0.00074 19.8 4.3 4.0 2 2 0 3 3 1 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI87426.1 - 0.0065 16.1 27.2 0.012 15.3 25.3 2.1 2 0 0 2 2 2 1 Spt20 family Suf PF05843.14 CDI87426.1 - 0.0097 15.9 6.8 0.017 15.1 6.8 1.4 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) DUF4770 PF15994.5 CDI87426.1 - 0.032 14.5 6.7 0.068 13.4 6.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Neur_chan_memb PF02932.16 CDI87426.1 - 0.14 12.2 1.7 0.26 11.3 1.2 1.7 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region V_ATPase_I PF01496.19 CDI87426.1 - 0.15 10.0 2.7 0.23 9.3 2.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ndc1_Nup PF09531.10 CDI87426.1 - 0.22 10.2 4.4 0.31 9.7 4.4 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Tmemb_9 PF05434.11 CDI87426.1 - 0.4 10.6 5.1 15 5.5 0.0 2.4 2 0 0 2 2 2 0 TMEM9 FAM83 PF07894.12 CDI87426.1 - 0.46 10.0 5.4 0.82 9.2 5.4 1.3 1 0 0 1 1 1 0 FAM83 A-H FHIPEP PF00771.20 CDI87426.1 - 0.52 8.7 3.6 0.38 9.2 0.4 2.1 3 0 0 3 3 3 0 FHIPEP family EPL1 PF10513.9 CDI87426.1 - 1 9.8 8.9 0.05 14.0 1.9 2.3 3 0 0 3 3 3 0 Enhancer of polycomb-like CLN3 PF02487.17 CDI87426.1 - 1 8.3 2.9 2.4 7.1 2.9 1.6 1 0 0 1 1 1 0 CLN3 protein HEPN_DZIP3 PF18738.1 CDI87426.1 - 1.2 8.9 6.5 3.7 7.3 5.8 2.0 2 0 0 2 2 2 0 DZIP3/ hRUL138-like HEPN ETRAMP PF09716.10 CDI87426.1 - 1.2 9.2 0.0 1.2 9.2 0.0 2.7 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) D123 PF07065.14 CDI87426.1 - 1.5 7.9 7.6 0.71 9.0 5.4 1.5 2 0 0 2 2 2 0 D123 eIF-3_zeta PF05091.12 CDI87426.1 - 2.5 7.0 11.1 3.9 6.4 11.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Band_3_cyto PF07565.13 CDI87426.1 - 2.8 7.7 6.5 0.35 10.6 2.5 1.5 2 0 0 2 2 1 0 Band 3 cytoplasmic domain DUF775 PF05603.12 CDI87426.1 - 3 7.3 10.7 2.3 7.7 7.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF775) PAT1 PF09770.9 CDI87426.1 - 3.5 5.8 17.8 5.1 5.2 17.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S49_N PF08496.10 CDI87426.1 - 4.4 7.4 9.5 0.15 12.1 2.9 1.9 3 0 0 3 3 2 0 Peptidase family S49 N-terminal CPSF100_C PF13299.6 CDI87426.1 - 5.4 7.2 12.0 1.8 8.7 5.5 2.6 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Hid1 PF12722.7 CDI87426.1 - 8.3 4.4 7.0 14 3.7 7.0 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UPF0560 PF10577.9 CDI87426.1 - 9 4.7 13.4 13 4.1 13.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TRAP_alpha PF03896.16 CDI87427.1 - 1.6 7.8 13.4 2.5 7.2 13.4 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Presenilin PF01080.17 CDI87427.1 - 7.7 5.2 25.8 8.1 5.1 25.8 1.0 1 0 0 1 1 1 0 Presenilin Serinc PF03348.15 CDI87428.1 - 0.084 11.8 5.8 0.11 11.4 5.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) FAM60A PF15396.6 CDI87428.1 - 0.37 10.8 9.2 0.5 10.3 9.2 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Peptidase_S49_N PF08496.10 CDI87428.1 - 0.46 10.5 11.9 0.15 12.1 8.8 1.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Vac7 PF12751.7 CDI87428.1 - 0.49 9.8 8.2 0.63 9.4 8.2 1.2 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 SID-1_RNA_chan PF13965.6 CDI87428.1 - 0.7 8.2 3.2 0.79 8.1 3.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RR_TM4-6 PF06459.12 CDI87428.1 - 0.81 9.5 16.6 1.2 8.9 16.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI87428.1 - 1.3 8.0 13.9 1.6 7.7 13.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 EOS1 PF12326.8 CDI87428.1 - 1.5 8.7 4.3 2.1 8.2 4.3 1.4 1 0 0 1 1 1 0 N-glycosylation protein PIP5K PF01504.18 CDI87428.1 - 1.7 7.8 13.2 2.5 7.2 13.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase ALMT PF11744.8 CDI87428.1 - 3 6.6 9.7 3.4 6.4 9.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SpoIIP PF07454.11 CDI87428.1 - 5.5 6.4 18.0 8.8 5.7 18.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF1387 PF07139.11 CDI87428.1 - 5.8 6.6 16.9 9.8 5.8 16.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) GREB1 PF15782.5 CDI87428.1 - 7.1 3.6 22.0 8.7 3.3 22.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RskA PF10099.9 CDI87429.1 - 3e-05 24.4 6.5 3e-05 24.4 6.5 9.3 2 2 1 5 5 5 2 Anti-sigma-K factor rskA Sin_N PF04801.13 CDI87429.1 - 0.003 16.9 15.5 0.003 16.9 15.5 6.0 3 2 1 5 5 5 2 Sin-like protein conserved region Presenilin PF01080.17 CDI87430.1 - 0.59 8.8 10.8 0.65 8.7 10.8 1.0 1 0 0 1 1 1 0 Presenilin MMU163 PF17119.5 CDI87430.1 - 0.71 9.0 10.4 0.86 8.7 10.4 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Striatin PF08232.12 CDI87430.1 - 1.1 9.8 8.6 1.3 9.6 8.6 1.1 1 0 0 1 1 1 0 Striatin family Velvet PF11754.8 CDI87430.1 - 1.3 8.9 12.4 1.5 8.7 12.4 1.1 1 0 0 1 1 1 0 Velvet factor NPR3 PF03666.13 CDI87430.1 - 2.2 7.0 15.3 2.5 6.8 15.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SPX PF03105.19 CDI87430.1 - 2.7 7.8 23.4 3.2 7.6 23.4 1.0 1 0 0 1 1 1 0 SPX domain Bul1_C PF04426.12 CDI87430.1 - 7 6.0 14.8 11 5.4 14.8 1.2 1 0 0 1 1 1 0 Bul1 C terminus DUF4614 PF15391.6 CDI87430.1 - 9.9 6.1 29.3 14 5.6 29.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) DHHW PF14286.6 CDI87432.1 - 1.1 8.5 0.0 1.1 8.5 0.0 4.8 4 0 0 4 4 4 0 DHHW protein Ribosomal_L37 PF08561.10 CDI87433.1 - 0.014 15.9 5.9 0.014 15.9 5.9 4.3 2 1 1 3 3 3 0 Mitochondrial ribosomal protein L37 ABC2_membrane_2 PF12679.7 CDI87433.1 - 1.7 7.9 12.6 0.25 10.6 1.2 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF2722 PF10846.8 CDI87434.1 - 0.00015 20.9 1.2 0.00015 20.9 1.2 19.4 15 5 3 18 18 18 5 Protein of unknown function (DUF2722) BUD22 PF09073.10 CDI87434.1 - 0.00055 19.4 0.3 0.00055 19.4 0.3 8.7 5 3 3 8 8 8 2 BUD22 RskA PF10099.9 CDI87434.1 - 0.0042 17.4 22.3 0.0042 17.4 22.3 26.9 6 6 17 25 25 25 5 Anti-sigma-K factor rskA TCP PF03634.13 CDI87434.1 - 0.0078 16.8 2.7 0.0078 16.8 2.7 15.3 12 4 1 13 13 13 2 TCP family transcription factor THRAP3_BCLAF1 PF15440.6 CDI87435.1 - 5.9 5.8 46.5 8 5.3 46.5 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family UPF0086 PF01868.16 CDI87436.1 - 1.3e-07 31.4 0.0 3.6e-07 30.0 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function UPF0086 DUF2235 PF09994.9 CDI87436.1 - 0.0095 15.3 1.7 0.0095 15.3 1.7 1.8 2 0 0 2 2 2 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF572 PF04502.13 CDI87436.1 - 0.16 11.5 15.0 0.24 11.0 15.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4604 PF15377.6 CDI87436.1 - 0.75 10.2 0.0 0.75 10.2 0.0 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4604) Paramyxo_ncap PF00973.19 CDI87436.1 - 10 4.9 8.8 18 4.1 8.8 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Macoilin PF09726.9 CDI87437.1 - 0.0039 15.8 19.9 0.0064 15.1 19.9 1.3 1 0 0 1 1 1 1 Macoilin family DUF2052 PF09747.9 CDI87437.1 - 0.01 16.0 7.5 0.016 15.3 7.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) LCD1 PF09798.9 CDI87437.1 - 0.017 13.7 5.6 0.02 13.4 5.6 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein SLC12 PF03522.15 CDI87437.1 - 0.069 12.2 8.2 0.085 11.9 8.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Ndc1_Nup PF09531.10 CDI87437.1 - 0.086 11.5 19.1 0.11 11.2 19.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup BUD22 PF09073.10 CDI87437.1 - 0.22 10.9 21.2 0.3 10.4 21.2 1.1 1 0 0 1 1 1 0 BUD22 Pol_alpha_B_N PF08418.10 CDI87437.1 - 0.28 11.1 16.4 0.41 10.6 16.4 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal PNISR PF15996.5 CDI87437.1 - 0.35 11.1 13.4 0.63 10.3 13.4 1.5 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF572 PF04502.13 CDI87437.1 - 0.38 10.3 11.4 0.54 9.8 11.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) PI3K_1B_p101 PF10486.9 CDI87437.1 - 0.59 7.9 18.9 0.81 7.4 18.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SOG2 PF10428.9 CDI87437.1 - 0.64 9.2 26.7 1.1 8.4 26.7 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Cwf_Cwc_15 PF04889.12 CDI87437.1 - 0.86 9.3 12.9 1.4 8.6 12.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Mcm10 PF09332.11 CDI87437.1 - 0.98 8.8 21.1 2.2 7.6 21.1 1.5 1 0 0 1 1 1 0 Mcm10 replication factor Apt1 PF10351.9 CDI87437.1 - 0.98 8.2 22.1 1.7 7.4 22.1 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain Plasmodium_Vir PF05795.11 CDI87437.1 - 1.2 8.5 13.7 1.8 7.9 13.7 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RED_N PF07808.13 CDI87437.1 - 1.3 8.6 9.8 2.3 7.8 9.8 1.3 1 0 0 1 1 1 0 RED-like protein N-terminal region Jak1_Phl PF17887.1 CDI87437.1 - 1.4 8.9 10.5 3.4 7.6 10.5 1.6 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain TFIIF_alpha PF05793.12 CDI87437.1 - 1.6 7.2 11.6 2.1 6.8 11.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SPX PF03105.19 CDI87437.1 - 2 8.2 30.8 2.9 7.7 30.8 1.1 1 0 0 1 1 1 0 SPX domain eIF-3_zeta PF05091.12 CDI87437.1 - 2.2 7.2 10.9 3 6.7 10.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF945 PF06097.11 CDI87437.1 - 2.8 6.9 19.8 5.7 5.9 19.8 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF945) FHIPEP PF00771.20 CDI87437.1 - 2.9 6.3 4.2 4 5.8 4.2 1.1 1 0 0 1 1 1 0 FHIPEP family PAT1 PF09770.9 CDI87437.1 - 3.1 6.0 17.2 4.1 5.6 17.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4407 PF14362.6 CDI87437.1 - 3.1 7.1 10.0 0.63 9.3 5.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) PAP1 PF08601.10 CDI87437.1 - 3.4 7.3 28.1 6.4 6.4 28.1 1.4 1 0 0 1 1 1 0 Transcription factor PAP1 NST1 PF13945.6 CDI87437.1 - 4.2 7.4 22.0 6.5 6.8 22.0 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator SRP-alpha_N PF04086.13 CDI87437.1 - 4.3 7.2 19.9 6.3 6.6 19.9 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal V_ATPase_I PF01496.19 CDI87437.1 - 5.8 4.7 6.4 7.8 4.3 6.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4770 PF15994.5 CDI87437.1 - 5.9 7.1 12.5 10 6.4 12.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Miga PF10265.9 CDI87437.1 - 9.3 5.1 20.7 13 4.6 20.7 1.1 1 0 0 1 1 1 0 Mitoguardin LAP1C PF05609.12 CDI87438.1 - 0.072 12.2 8.1 0.074 12.1 8.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GET2 PF08690.10 CDI87438.1 - 0.19 11.3 15.9 0.21 11.3 15.9 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 DUF973 PF06157.11 CDI87438.1 - 0.62 9.1 3.3 0.77 8.8 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF973) DUF4079 PF13301.6 CDI87438.1 - 0.81 9.8 6.3 1.6 8.9 6.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) Consortin_C PF15281.6 CDI87438.1 - 3.5 7.6 5.7 0.4 10.7 0.8 1.7 1 1 1 2 2 2 0 Consortin C-terminus Orf78 PF06024.12 CDI87438.1 - 6.1 7.2 6.3 5.5 7.4 0.7 2.0 1 1 1 2 2 2 0 Orf78 (ac78) SUI1 PF01253.22 CDI87441.1 - 1.3e-15 57.7 0.1 3.1e-15 56.5 0.1 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 Cation_ATPase_N PF00690.26 CDI87442.1 - 0.11 12.2 0.2 0.79 9.5 0.0 2.3 2 0 0 2 2 2 0 Cation transporter/ATPase, N-terminus TLD PF07534.16 CDI87443.1 - 2.2e-20 73.3 0.0 1.4e-19 70.7 0.0 1.9 2 0 0 2 2 2 1 TLD ACC_epsilon PF13822.6 CDI87443.1 - 0.16 12.6 1.4 0.31 11.7 1.4 1.4 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit Ribosomal_L29 PF00831.23 CDI87444.1 - 1.9e-16 59.8 3.1 1.9e-16 59.8 3.1 2.0 2 1 0 2 2 2 1 Ribosomal L29 protein TolA_bind_tri PF16331.5 CDI87444.1 - 0.047 13.8 2.1 0.065 13.3 0.8 1.8 2 0 0 2 2 2 0 TolA binding protein trimerisation MRP-L47 PF06984.13 CDI87444.1 - 1 9.6 5.7 0.21 11.8 0.9 2.2 2 2 1 3 3 3 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) AAA_6 PF12774.7 CDI87445.1 - 8e-128 426.0 0.0 1.1e-126 422.2 0.0 3.0 3 0 0 3 3 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDI87445.1 - 1.5e-114 383.2 7.1 1.5e-114 383.2 7.1 3.7 4 0 0 4 4 3 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 CDI87445.1 - 7.7e-110 368.2 3.5 7.7e-110 368.2 3.5 4.3 4 1 0 4 4 4 2 Dynein heavy chain, N-terminal region 1 AAA_9 PF12781.7 CDI87445.1 - 5.7e-68 228.3 0.2 5.7e-68 228.3 0.2 3.6 4 0 0 4 4 3 1 ATP-binding dynein motor region AAA_8 PF12780.7 CDI87445.1 - 6.5e-63 212.5 0.0 2.3e-61 207.4 0.0 3.2 3 0 0 3 3 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 CDI87445.1 - 8.3e-49 166.5 0.1 2.6e-48 164.8 0.1 1.9 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 CDI87445.1 - 6.1e-36 123.6 0.0 5.3e-29 101.0 0.0 4.5 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 CDI87445.1 - 3.2e-33 114.9 0.0 7.1e-33 113.7 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 CDI87445.1 - 2.5e-30 105.0 2.6 7.4e-30 103.5 0.0 3.4 3 0 0 3 3 1 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 CDI87445.1 - 2.6e-30 105.2 0.0 4.4e-11 42.9 0.0 6.2 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) MT PF12777.7 CDI87445.1 - 8.9e-29 100.6 10.4 1.5e-28 99.8 10.4 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA PF00004.29 CDI87445.1 - 2.7e-15 56.9 0.2 0.0061 17.0 0.0 6.1 5 0 0 5 5 5 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDI87445.1 - 2.6e-12 47.2 3.9 0.00072 19.8 0.0 7.8 7 1 0 7 7 5 1 AAA domain Dynein_AAA_lid PF17852.1 CDI87445.1 - 2.4e-11 43.8 0.0 1.2e-10 41.6 0.0 2.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_18 PF13238.6 CDI87445.1 - 2e-07 31.6 0.1 7.9 7.0 0.0 5.7 5 0 0 5 5 4 0 AAA domain AAA_16 PF13191.6 CDI87445.1 - 4.3e-06 27.2 10.8 4.9 7.5 0.0 7.4 7 1 0 8 8 4 0 AAA ATPase domain T2SSE PF00437.20 CDI87445.1 - 6.1e-06 25.5 0.0 0.099 11.7 0.0 3.4 3 0 0 3 3 3 2 Type II/IV secretion system protein AAA_30 PF13604.6 CDI87445.1 - 5.3e-05 23.0 0.9 5.6 6.6 0.0 4.8 4 0 0 4 4 4 0 AAA domain AAA_25 PF13481.6 CDI87445.1 - 9.8e-05 22.0 0.8 0.013 15.1 0.0 3.8 4 0 0 4 4 3 1 AAA domain TelA PF05816.11 CDI87445.1 - 0.00044 19.4 5.0 0.00044 19.4 5.0 3.1 2 0 0 2 2 1 1 Toxic anion resistance protein (TelA) IstB_IS21 PF01695.17 CDI87445.1 - 0.00047 19.9 0.6 0.21 11.3 0.0 4.5 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_33 PF13671.6 CDI87445.1 - 0.00075 19.7 6.8 0.74 10.0 0.0 5.1 5 0 0 5 5 4 1 AAA domain AAA_19 PF13245.6 CDI87445.1 - 0.0008 19.8 0.8 0.23 11.8 0.0 4.8 5 0 0 5 5 4 1 AAA domain Rad17 PF03215.15 CDI87445.1 - 0.0054 16.7 0.7 19 5.1 0.0 4.6 6 0 0 6 6 4 0 Rad17 P-loop domain TsaE PF02367.17 CDI87445.1 - 0.0095 15.9 1.3 19 5.3 0.0 4.3 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Asn_synthase PF00733.21 CDI87445.1 - 0.01 15.5 0.2 0.027 14.1 0.2 1.7 1 0 0 1 1 1 0 Asparagine synthase Sigma54_activat PF00158.26 CDI87445.1 - 0.02 14.6 0.0 52 3.5 0.0 3.8 3 0 0 3 3 3 0 Sigma-54 interaction domain RNA_helicase PF00910.22 CDI87445.1 - 0.021 15.2 0.1 1.2e+02 3.1 0.0 4.7 4 0 0 4 4 4 0 RNA helicase RuvB_N PF05496.12 CDI87445.1 - 0.022 14.5 0.1 3.8 7.2 0.0 3.6 4 0 0 4 4 4 0 Holliday junction DNA helicase RuvB P-loop domain cobW PF02492.19 CDI87445.1 - 0.024 14.2 0.2 0.22 11.1 0.0 2.6 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain MPS2 PF17060.5 CDI87445.1 - 0.03 13.6 10.8 0.35 10.1 3.4 2.7 2 0 0 2 2 2 0 Monopolar spindle protein 2 AAA_lid_1 PF17857.1 CDI87445.1 - 0.036 14.3 0.0 0.1 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA+ lid domain NBD94 PF16830.5 CDI87445.1 - 0.072 13.5 2.7 0.36 11.3 2.7 2.3 1 0 0 1 1 1 0 Nucleotide-Binding Domain 94 of RH Mg_chelatase PF01078.21 CDI87445.1 - 0.073 12.4 7.7 6.6 6.0 0.0 4.6 4 1 1 5 5 5 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 CDI87445.1 - 0.089 12.1 0.2 12 5.1 0.0 4.0 4 0 0 4 4 4 0 Zeta toxin AAA_24 PF13479.6 CDI87445.1 - 0.21 11.3 3.5 19 4.9 0.0 4.2 5 0 0 5 5 3 0 AAA domain LPP PF04728.13 CDI87445.1 - 0.27 11.7 4.7 22 5.5 0.8 4.2 2 0 0 2 2 2 0 Lipoprotein leucine-zipper ABC_tran PF00005.27 CDI87445.1 - 0.49 10.9 7.9 17 5.9 0.0 5.1 5 0 0 5 5 3 0 ABC transporter ATG16 PF08614.11 CDI87445.1 - 0.81 9.9 25.9 5.1 7.3 9.9 3.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF4615 PF15393.6 CDI87445.1 - 1.7 9.2 6.5 2.1 8.9 0.2 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4615) Presenilin PF01080.17 CDI87446.1 - 4.2e-07 29.1 25.5 4.2e-07 29.1 25.5 2.3 2 1 0 2 2 1 1 Presenilin Caldesmon PF02029.15 CDI87446.1 - 1.6e-06 27.2 56.8 0.00027 19.9 18.4 2.0 2 0 0 2 2 2 2 Caldesmon Hid1 PF12722.7 CDI87446.1 - 0.00013 20.3 13.4 0.00013 20.3 13.4 2.1 2 0 0 2 2 2 2 High-temperature-induced dauer-formation protein Dapper PF15268.6 CDI87446.1 - 0.0013 17.7 62.8 0.031 13.2 19.4 2.1 2 0 0 2 2 2 2 Dapper CDC45 PF02724.14 CDI87446.1 - 0.0019 16.6 22.2 0.0019 16.6 22.2 2.1 2 0 0 2 2 2 1 CDC45-like protein Lin-8 PF03353.15 CDI87446.1 - 0.0028 17.3 18.6 0.0028 17.3 18.6 2.3 2 0 0 2 2 2 1 Ras-mediated vulval-induction antagonist SAPS PF04499.15 CDI87446.1 - 0.0034 16.3 22.7 0.0034 16.3 22.7 2.1 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein PAT1 PF09770.9 CDI87446.1 - 0.0042 15.4 96.1 0.018 13.4 33.3 2.1 2 0 0 2 2 2 2 Topoisomerase II-associated protein PAT1 DUF4045 PF13254.6 CDI87446.1 - 0.0073 16.0 55.9 0.029 14.0 26.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4045) Apt1 PF10351.9 CDI87446.1 - 0.011 14.7 39.3 0.14 11.0 19.3 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain LTV PF04180.14 CDI87446.1 - 0.037 13.8 48.4 0.026 14.3 13.6 2.3 2 0 0 2 2 2 0 Low temperature viability protein DUF2151 PF10221.9 CDI87446.1 - 0.14 10.7 39.8 0.015 13.9 8.7 2.1 2 0 0 2 2 2 0 Cell cycle and development regulator AF-4 PF05110.13 CDI87446.1 - 0.15 10.1 70.2 0.023 12.8 21.4 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Draxin PF15550.6 CDI87446.1 - 0.58 10.0 49.7 0.16 11.8 18.6 2.5 3 0 0 3 3 2 0 Draxin Zip PF02535.22 CDI87446.1 - 0.59 9.3 42.5 0.064 12.5 7.5 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter Hydin_ADK PF17213.3 CDI87446.1 - 0.71 10.1 55.8 0.08 13.2 22.5 3.1 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain ASD2 PF08687.11 CDI87446.1 - 1.3 8.5 66.2 0.64 9.5 31.2 2.4 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 AAA_11 PF13086.6 CDI87446.1 - 1.5 8.6 67.3 0.51 10.1 29.2 2.2 2 0 0 2 2 2 0 AAA domain Spore_coat_CotO PF14153.6 CDI87446.1 - 1.6 8.6 82.5 0.88 9.5 29.2 2.7 2 0 0 2 2 2 0 Spore coat protein CotO Hamartin PF04388.12 CDI87446.1 - 1.9 7.0 58.6 0.14 10.8 16.8 2.1 2 0 0 2 2 2 0 Hamartin protein BAF1_ABF1 PF04684.13 CDI87446.1 - 2 7.4 63.2 0.1 11.6 19.4 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Pkinase_fungal PF17667.1 CDI87446.1 - 2.8 6.6 38.2 3.2 6.4 11.8 2.2 2 0 0 2 2 2 0 Fungal protein kinase FAM60A PF15396.6 CDI87446.1 - 3.6 7.5 58.3 0.81 9.7 24.3 2.4 2 0 0 2 2 2 0 Protein Family FAM60A RIFIN PF02009.16 CDI87446.1 - 4.7 7.0 51.5 2.8 7.7 14.2 3.3 3 0 0 3 3 3 0 Rifin DUF4778 PF16008.5 CDI87446.1 - 8.3 6.4 48.7 0.093 12.8 11.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4778) CENP-N PF05238.13 CDI87446.1 - 9.3 5.4 41.0 6.3 6.0 12.7 2.2 2 0 0 2 2 2 0 Kinetochore protein CHL4 like Topoisom_I_N PF02919.15 CDI87449.1 - 1.6e-14 53.9 1.0 3.6e-14 52.8 0.4 1.8 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment TFIIA PF03153.13 CDI87449.1 - 0.54 10.2 9.3 0.69 9.8 9.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_S64 PF08192.11 CDI87449.1 - 1.6 7.2 10.2 1.9 6.9 10.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 SPX PF03105.19 CDI87449.1 - 4.8 7.0 14.8 6.4 6.6 14.8 1.2 1 0 0 1 1 1 0 SPX domain AF-4 PF05110.13 CDI87449.1 - 8.7 4.3 22.0 11 3.9 22.0 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Androgen_recep PF02166.16 CDI87451.1 - 0.0036 16.2 14.3 0.0036 16.2 14.3 16.7 3 1 11 16 16 16 3 Androgen receptor DUF819 PF05684.12 CDI87453.1 - 8.9 5.2 8.1 0.47 9.4 1.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF819) DUF2722 PF10846.8 CDI87458.1 - 0.00043 19.3 4.0 0.00043 19.3 4.0 7.5 4 2 2 7 7 7 2 Protein of unknown function (DUF2722) PIP5K PF01504.18 CDI87458.1 - 0.011 14.9 0.9 0.011 14.9 0.9 4.6 4 2 0 4 4 4 0 Phosphatidylinositol-4-phosphate 5-Kinase Utp14 PF04615.13 CDI87458.1 - 0.29 9.6 47.4 0.11 11.1 15.1 3.0 3 0 0 3 3 3 0 Utp14 protein HGTP_anticodon2 PF12745.7 CDI87459.1 - 1.1 8.7 8.1 1.5 8.2 8.1 1.3 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Presenilin PF01080.17 CDI87459.1 - 3.8 6.2 12.4 4.3 6.0 12.4 1.3 1 0 0 1 1 1 0 Presenilin SPX PF03105.19 CDI87459.1 - 4.3 7.2 24.8 5.2 6.9 24.8 1.2 1 0 0 1 1 1 0 SPX domain FAM196 PF15265.6 CDI87459.1 - 6.9 6.0 17.2 7.3 6.0 17.2 1.1 1 0 0 1 1 1 0 FAM196 family FAM176 PF14851.6 CDI87460.1 - 0.51 10.0 23.4 0.21 11.2 0.3 3.2 4 0 0 4 4 4 0 FAM176 family FAM209 PF15206.6 CDI87460.1 - 3.6 7.4 11.6 18 5.1 4.2 2.7 1 1 1 2 2 2 0 FAM209 family RskA PF10099.9 CDI87462.1 - 2e-05 25.0 0.1 2e-05 25.0 0.1 18.3 2 2 10 12 12 12 2 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI87462.1 - 0.0014 17.6 14.6 0.0014 17.6 14.6 8.7 7 3 1 8 8 8 3 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI87462.1 - 0.0043 16.7 22.9 0.0043 16.7 22.9 8.8 7 2 1 8 8 8 5 Spt20 family SR-25 PF10500.9 CDI87462.1 - 0.0057 16.3 13.1 0.0057 16.3 13.1 11.3 8 4 4 14 14 14 3 Nuclear RNA-splicing-associated protein WD40 PF00400.32 CDI87463.1 - 1.9e-06 28.5 5.0 0.0018 19.1 0.0 5.7 6 0 0 6 6 6 2 WD domain, G-beta repeat SR-25 PF10500.9 CDI87463.1 - 0.0012 18.5 7.6 0.0012 18.5 7.6 9.5 9 2 0 9 9 9 3 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI87463.1 - 0.0052 16.4 2.9 0.0052 16.4 2.9 9.7 9 1 1 10 10 10 6 Spt20 family Rer1 PF03248.13 CDI87465.1 - 2.1e-61 206.6 4.0 2.6e-61 206.3 4.0 1.1 1 0 0 1 1 1 1 Rer1 family Bromodomain PF00439.25 CDI87466.1 - 1.1e-33 115.1 0.0 2e-18 66.2 0.0 2.3 2 0 0 2 2 2 2 Bromodomain DUF726 PF05277.12 CDI87467.1 - 1.6e-63 214.7 5.9 4.2e-32 111.4 0.1 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF726) tRNA-synt_2b PF00587.25 CDI87469.1 - 5.2e-23 81.9 0.0 9.6e-23 81.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 CDI87469.1 - 3.9e-20 72.2 0.1 6.7e-20 71.4 0.1 1.4 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain SR-25 PF10500.9 CDI87469.1 - 0.0015 18.2 3.0 0.0027 17.4 3.0 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein HGTP_anticodon PF03129.20 CDI87469.1 - 0.0066 16.6 0.1 0.037 14.2 0.0 2.1 2 0 0 2 2 2 1 Anticodon binding domain Cas_Cas1 PF01867.16 CDI87469.1 - 0.081 12.0 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 CRISPR associated protein Cas1 DUF4701 PF15773.5 CDI87469.1 - 0.19 10.7 5.3 0.33 9.9 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4701) Ribosomal_60s PF00428.19 CDI87469.1 - 0.83 10.3 6.8 0.5 11.0 3.5 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein TCP PF03634.13 CDI87469.1 - 1.5 9.4 5.9 4.2 7.9 5.9 1.7 1 0 0 1 1 1 0 TCP family transcription factor DUF2722 PF10846.8 CDI87470.1 - 2.2e-06 26.9 5.8 2.2e-06 26.9 5.8 4.9 2 1 1 3 3 3 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI87470.1 - 0.047 14.0 1.1 0.047 14.0 1.1 5.1 3 1 2 5 5 5 0 Anti-sigma-K factor rskA DUF5585 PF17823.1 CDI87470.1 - 2.4 7.0 42.6 0.027 13.4 27.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5585) DUF4834 PF16118.5 CDI87471.1 - 4.7e-05 24.3 1.4 4.7e-05 24.3 1.4 8.6 4 2 2 6 6 6 1 Domain of unknown function (DUF4834) RskA PF10099.9 CDI87471.1 - 0.00024 21.4 12.8 0.00024 21.4 12.8 8.7 2 2 3 5 5 5 1 Anti-sigma-K factor rskA SARAF PF06682.12 CDI87471.1 - 0.00028 20.7 25.1 0.00028 20.7 25.1 6.1 3 1 2 5 5 5 1 SOCE-associated regulatory factor of calcium homoeostasis WSD PF15613.6 CDI87471.1 - 0.0032 17.9 1.9 0.0032 17.9 1.9 6.1 4 3 0 4 4 4 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif MID_MedPIWI PF18296.1 CDI87472.1 - 7.6e-05 22.6 8.0 7.6e-05 22.6 8.0 5.6 3 2 1 4 4 4 1 MID domain of medPIWI Ribosomal_L7Ae PF01248.26 CDI87473.1 - 3.7e-26 90.7 0.4 4.8e-26 90.3 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SpoU_sub_bind PF08032.12 CDI87473.1 - 0.022 15.0 0.0 0.04 14.2 0.0 1.5 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding Spt20 PF12090.8 CDI87474.1 - 0.025 14.2 1.4 0.028 14.1 1.4 1.2 1 0 0 1 1 1 0 Spt20 family PIG-U PF06728.13 CDI87474.1 - 0.21 10.6 3.1 0.26 10.3 3.1 1.1 1 0 0 1 1 1 0 GPI transamidase subunit PIG-U DUF2722 PF10846.8 CDI87475.1 - 0.00021 20.4 7.9 0.00021 20.4 7.9 7.3 4 1 3 7 7 7 2 Protein of unknown function (DUF2722) DUF1980 PF09323.10 CDI87475.1 - 0.00037 20.4 0.9 0.00037 20.4 0.9 6.2 4 1 1 5 5 5 1 Domain of unknown function (DUF1980) SUIM_assoc PF16619.5 CDI87475.1 - 0.0099 15.9 3.7 0.0099 15.9 3.7 12.6 5 4 2 7 7 7 2 Unstructured region C-term to UIM in Ataxin3 DUF4834 PF16118.5 CDI87475.1 - 0.2 12.7 0.3 0.2 12.7 0.3 7.5 4 1 3 7 7 7 0 Domain of unknown function (DUF4834) CENP-L PF13092.6 CDI87477.1 - 0.013 15.8 2.0 0.017 15.4 2.0 1.1 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 TFIIA PF03153.13 CDI87477.1 - 0.016 15.3 23.1 0.018 15.1 23.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI87477.1 - 0.046 13.3 22.7 0.054 13.1 22.7 1.1 1 0 0 1 1 1 0 Spt20 family DUF2062 PF09835.9 CDI87477.1 - 0.053 13.4 4.2 0.068 13.0 4.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) RAB3GAP2_N PF14655.6 CDI87477.1 - 0.071 12.4 3.8 0.073 12.3 3.8 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Suf PF05843.14 CDI87477.1 - 0.078 13.0 6.6 0.077 13.0 6.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Roughex PF06020.11 CDI87477.1 - 0.11 11.5 4.3 0.11 11.6 4.3 1.1 1 0 0 1 1 1 0 Drosophila roughex protein FHIPEP PF00771.20 CDI87477.1 - 0.2 10.1 5.7 0.22 10.0 5.7 1.0 1 0 0 1 1 1 0 FHIPEP family DivIC PF04977.15 CDI87477.1 - 0.21 11.4 12.1 0.31 10.8 12.1 1.3 1 0 0 1 1 1 0 Septum formation initiator eIF-3_zeta PF05091.12 CDI87477.1 - 0.24 10.4 8.4 0.26 10.2 8.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI87477.1 - 0.32 9.7 4.7 0.34 9.6 4.7 1.1 1 0 0 1 1 1 0 Presenilin DUF533 PF04391.12 CDI87477.1 - 0.46 10.0 19.9 0.52 9.9 19.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF533) Tic110 PF16940.5 CDI87477.1 - 0.59 8.6 13.2 0.63 8.5 13.2 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF2232 PF09991.9 CDI87477.1 - 0.63 9.2 3.9 0.78 8.9 3.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) FAM199X PF15814.5 CDI87477.1 - 0.76 8.8 5.8 0.91 8.5 5.8 1.2 1 0 0 1 1 1 0 Protein family FAM199X DUF2298 PF10060.9 CDI87477.1 - 0.96 8.1 7.5 1.1 7.9 7.5 1.1 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) TraU PF06834.11 CDI87477.1 - 1.3 8.2 9.8 1.6 7.9 9.8 1.1 1 0 0 1 1 1 0 TraU protein DUF2722 PF10846.8 CDI87477.1 - 1.5 7.7 22.1 2.3 7.1 22.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF5585 PF17823.1 CDI87477.1 - 2.1 7.2 19.0 2.6 6.9 19.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Activator_LAG-3 PF11498.8 CDI87477.1 - 5.2 5.9 27.1 6.1 5.7 27.1 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 GREB1 PF15782.5 CDI87478.1 - 0.00017 18.9 7.5 0.00017 18.9 7.5 2.0 2 0 0 2 2 2 1 Gene regulated by oestrogen in breast cancer RskA PF10099.9 CDI87478.1 - 0.00037 20.8 7.7 0.00037 20.8 7.7 4.3 1 1 2 4 4 2 2 Anti-sigma-K factor rskA SPX PF03105.19 CDI87478.1 - 0.0018 18.3 7.1 0.0018 18.3 7.1 2.1 2 0 0 2 2 2 1 SPX domain CNDH2_C PF16858.5 CDI87478.1 - 0.0025 17.7 24.2 0.12 12.2 6.4 2.1 2 0 0 2 2 2 2 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF3807 PF12720.7 CDI87478.1 - 0.0029 17.9 29.7 0.0058 16.9 9.2 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3807) Spt20 PF12090.8 CDI87478.1 - 0.0038 16.9 33.3 0.0038 16.9 33.3 3.2 2 1 1 3 3 2 1 Spt20 family DUF572 PF04502.13 CDI87478.1 - 0.0043 16.7 19.2 0.084 12.5 1.8 2.1 2 0 0 2 2 2 2 Family of unknown function (DUF572) BORG_CEP PF14957.6 CDI87478.1 - 0.0065 17.6 6.0 0.0065 17.6 6.0 2.6 2 1 0 2 2 1 1 Cdc42 effector CCSAP PF15748.5 CDI87478.1 - 0.0077 16.4 28.3 0.041 14.1 12.4 2.2 2 0 0 2 2 2 2 Centriole, cilia and spindle-associated Vfa1 PF08432.10 CDI87478.1 - 0.0086 16.4 25.6 0.34 11.2 10.9 2.2 2 0 0 2 2 2 2 AAA-ATPase Vps4-associated protein 1 V_ATPase_I PF01496.19 CDI87478.1 - 0.01 13.8 24.8 0.014 13.4 5.0 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF1645 PF07816.11 CDI87478.1 - 0.011 16.4 12.0 0.011 16.4 12.0 2.8 2 1 1 3 3 2 0 Protein of unknown function (DUF1645) EPL1 PF10513.9 CDI87478.1 - 0.011 16.1 7.7 0.011 16.1 7.7 3.1 2 1 0 2 2 1 0 Enhancer of polycomb-like Apt1 PF10351.9 CDI87478.1 - 0.013 14.4 17.9 0.0088 14.9 7.7 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain AAA_11 PF13086.6 CDI87478.1 - 0.013 15.3 17.1 0.078 12.7 4.5 2.1 2 0 0 2 2 2 0 AAA domain DUF913 PF06025.12 CDI87478.1 - 0.017 14.1 17.2 0.25 10.3 5.8 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) SURF6 PF04935.12 CDI87478.1 - 0.03 14.1 31.2 0.16 11.7 13.7 2.2 2 0 0 2 2 2 0 Surfeit locus protein 6 SR-25 PF10500.9 CDI87478.1 - 0.038 13.6 24.6 0.091 12.4 19.0 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Aminotran_4 PF01063.19 CDI87478.1 - 0.043 13.7 0.3 2.1 8.1 0.0 3.2 3 1 1 4 4 4 0 Amino-transferase class IV SpoIIIAH PF12685.7 CDI87478.1 - 0.076 12.8 26.0 0.13 12.1 9.4 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein Neur_chan_memb PF02932.16 CDI87478.1 - 0.094 12.8 24.0 0.3 11.1 6.1 2.5 3 0 0 3 3 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF4045 PF13254.6 CDI87478.1 - 0.14 11.8 25.9 0.073 12.7 10.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) Peroxin-3 PF04882.12 CDI87478.1 - 0.16 11.0 29.4 0.033 13.2 9.0 2.2 2 0 0 2 2 2 0 Peroxin-3 Endostatin PF06482.11 CDI87478.1 - 0.18 11.2 22.9 0.27 10.7 7.2 2.1 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Tim54 PF11711.8 CDI87478.1 - 0.26 10.0 24.3 0.074 11.8 8.4 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 CDI87478.1 - 0.27 11.0 27.8 0.11 12.4 9.4 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF908 PF06012.12 CDI87478.1 - 0.29 10.5 28.6 0.44 9.9 9.9 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) MMR1 PF08505.10 CDI87478.1 - 0.31 11.3 36.0 1 9.6 9.3 2.3 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein SRP-alpha_N PF04086.13 CDI87478.1 - 0.39 10.6 28.1 1.1 9.2 14.3 2.2 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal ALMT PF11744.8 CDI87478.1 - 0.4 9.4 24.4 1.3 7.7 6.1 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter DUF4366 PF14283.6 CDI87478.1 - 0.47 10.5 20.1 0.078 13.0 4.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Presenilin PF01080.17 CDI87478.1 - 0.5 9.1 37.5 0.28 9.9 16.8 2.2 2 0 0 2 2 2 0 Presenilin PAT1 PF09770.9 CDI87478.1 - 0.57 8.4 50.5 0.41 8.9 24.5 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SARAF PF06682.12 CDI87478.1 - 0.58 9.8 31.7 0.47 10.1 10.9 2.4 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis CLN3 PF02487.17 CDI87478.1 - 0.58 9.2 18.1 0.59 9.1 5.9 2.1 2 0 0 2 2 2 0 CLN3 protein Spore_coat_CotO PF14153.6 CDI87478.1 - 0.61 10.0 39.1 0.91 9.4 14.5 2.4 2 0 0 2 2 2 0 Spore coat protein CotO ASD2 PF08687.11 CDI87478.1 - 0.64 9.5 25.6 0.46 10.0 8.6 2.3 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Anoctamin PF04547.12 CDI87478.1 - 0.69 8.7 5.6 4.4 6.0 0.2 2.2 2 0 0 2 2 2 0 Calcium-activated chloride channel Sporozoite_P67 PF05642.11 CDI87478.1 - 0.74 7.8 16.3 0.036 12.2 5.0 2.4 2 0 0 2 2 2 0 Sporozoite P67 surface antigen OATP PF03137.20 CDI87478.1 - 1.1 7.5 10.2 1.2 7.3 2.4 2.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family PAXIP1_C PF15364.6 CDI87478.1 - 1.7 9.0 23.2 2.1 8.7 2.2 3.3 3 0 0 3 3 3 0 PAXIP1-associated-protein-1 C term PTIP binding protein SLC12 PF03522.15 CDI87478.1 - 2.1 7.3 30.3 2.8 6.8 13.2 2.1 2 0 0 2 2 2 0 Solute carrier family 12 FAM60A PF15396.6 CDI87478.1 - 2.5 8.1 23.1 1 9.3 7.8 2.2 2 0 0 2 2 2 0 Protein Family FAM60A DUF1387 PF07139.11 CDI87478.1 - 2.6 7.7 28.5 0.84 9.3 11.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) Serinc PF03348.15 CDI87478.1 - 3.4 6.5 14.0 4.7 6.0 2.0 2.2 2 0 0 2 2 2 0 Serine incorporator (Serinc) TFIIF_alpha PF05793.12 CDI87478.1 - 3.9 6.0 24.1 0.13 10.8 9.0 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Hid1 PF12722.7 CDI87478.1 - 5 5.1 29.6 1.4 6.9 6.8 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein DUF4746 PF15928.5 CDI87478.1 - 9.1 5.6 25.1 8.3 5.7 11.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) AUX_IAA PF02309.16 CDI87478.1 - 9.3 6.0 17.4 1.4 8.8 3.5 2.2 2 0 0 2 2 2 0 AUX/IAA family RskA PF10099.9 CDI87479.1 - 0.0021 18.4 14.7 0.0021 18.4 14.7 7.8 4 1 2 6 6 6 1 Anti-sigma-K factor rskA SPX PF03105.19 CDI87479.1 - 0.0044 17.0 10.2 0.0044 17.0 10.2 3.4 3 1 0 3 3 3 1 SPX domain DUF4667 PF15700.5 CDI87479.1 - 0.79 9.8 43.7 1.7 8.7 5.8 5.0 5 0 0 5 5 5 0 Domain of unknown function (DUF4667) PIG-U PF06728.13 CDI87480.1 - 0.0075 15.4 0.3 0.016 14.3 0.1 1.6 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U Conotoxin PF02950.17 CDI87480.1 - 0.031 15.3 5.3 0.031 15.3 5.3 2.5 2 0 0 2 2 2 0 Conotoxin DUF4834 PF16118.5 CDI87480.1 - 0.042 14.8 10.0 0.042 14.8 10.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF572 PF04502.13 CDI87480.1 - 0.25 10.9 13.4 0.37 10.4 13.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) SpoIIP PF07454.11 CDI87480.1 - 0.3 10.5 11.6 0.33 10.3 8.0 2.0 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) PRC2_HTH_1 PF18118.1 CDI87480.1 - 0.31 11.9 10.0 0.18 12.6 4.9 2.2 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Eapp_C PF10238.9 CDI87480.1 - 0.62 10.1 14.7 0.093 12.8 6.4 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein FAM176 PF14851.6 CDI87480.1 - 0.78 9.4 6.2 0.36 10.5 3.5 1.8 2 0 0 2 2 2 0 FAM176 family DUF2207 PF09972.9 CDI87480.1 - 0.83 8.3 4.1 7.5 5.2 0.0 2.0 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4820 PF16091.5 CDI87480.1 - 0.86 8.9 10.2 0.73 9.2 5.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) ATG22 PF11700.8 CDI87480.1 - 1.1 7.8 5.5 0.21 10.2 1.8 1.5 2 0 0 2 2 2 0 Vacuole effluxer Atg22 like Afi1 PF07792.12 CDI87480.1 - 1.2 9.7 10.9 0.63 10.5 7.1 2.0 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking OATP PF03137.20 CDI87480.1 - 1.4 7.1 7.7 0.19 10.0 3.7 1.5 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family FAM60A PF15396.6 CDI87480.1 - 1.8 8.6 9.8 0.62 10.0 3.9 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Peroxin-13_N PF04088.13 CDI87480.1 - 2.3 8.5 9.3 0.51 10.6 3.9 2.1 2 0 0 2 2 2 0 Peroxin 13, N-terminal region PEHE PF15275.6 CDI87480.1 - 2.4 8.8 13.6 1.2 9.7 10.3 2.0 2 0 0 2 2 2 0 PEHE domain V_ATPase_I PF01496.19 CDI87480.1 - 2.8 5.7 12.6 0.21 9.5 7.2 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Coilin_N PF15862.5 CDI87480.1 - 2.9 7.7 19.5 0.42 10.4 11.3 2.3 2 0 0 2 2 2 0 Coilin N-terminus TERB2 PF15101.6 CDI87480.1 - 3.1 7.8 20.7 0.3 11.1 13.6 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 MPM1 PF17234.2 CDI87480.1 - 3.1 8.0 13.7 0.53 10.5 9.1 1.8 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 PigN PF04987.14 CDI87480.1 - 3.2 6.5 6.4 1.1 8.0 3.9 1.5 2 0 0 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) SID-1_RNA_chan PF13965.6 CDI87480.1 - 4.5 5.6 7.0 0.95 7.8 3.8 1.4 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 CDC24_OB1 PF17246.2 CDI87480.1 - 4.6 7.4 7.9 1.2 9.3 3.9 1.9 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 1 Peptidase_S49_N PF08496.10 CDI87480.1 - 5.5 7.0 12.8 0.36 10.9 5.5 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Sec62 PF03839.16 CDI87480.1 - 6.2 6.3 10.4 3.8 7.0 5.4 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 Folliculin PF11704.8 CDI87480.1 - 7.1 6.5 14.1 1.6 8.6 6.6 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Baculo_PP31 PF05311.11 CDI87480.1 - 7.1 6.0 17.4 2.3 7.7 10.6 2.1 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) TFB6 PF17110.5 CDI87480.1 - 7.9 6.2 10.2 1 9.1 5.8 1.6 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF1764 PF08576.10 CDI87480.1 - 8.8 7.3 14.5 2.2 9.2 6.9 2.4 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) RskA PF10099.9 CDI87481.1 - 0.0097 16.2 42.2 0.088 13.1 42.2 2.0 1 1 0 1 1 1 1 Anti-sigma-K factor rskA CD20 PF04103.15 CDI87481.1 - 0.072 13.2 3.1 0.13 12.4 3.1 1.5 1 1 0 1 1 1 0 CD20-like family TraT PF05818.12 CDI87481.1 - 0.14 11.8 23.8 0.17 11.5 23.8 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein DUF2298 PF10060.9 CDI87481.1 - 0.14 10.8 8.3 0.16 10.6 8.3 1.2 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) SID-1_RNA_chan PF13965.6 CDI87481.1 - 0.31 9.4 8.0 0.38 9.1 8.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SprA-related PF12118.8 CDI87481.1 - 0.38 9.8 46.9 0.49 9.5 46.9 1.1 1 0 0 1 1 1 0 SprA-related family DUF2232 PF09991.9 CDI87481.1 - 0.6 9.2 10.9 0.95 8.6 10.9 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2232) eIF-3_zeta PF05091.12 CDI87481.1 - 0.89 8.5 23.4 1 8.3 23.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CAF1 PF04857.20 CDI87481.1 - 1.9 7.5 10.9 2.5 7.2 10.9 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease Serinc PF03348.15 CDI87481.1 - 2.2 7.1 14.0 3.1 6.6 14.0 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) EIF4E-T PF10477.9 CDI87481.1 - 2.3 6.9 25.8 2.6 6.8 25.8 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E TFIIA PF03153.13 CDI87481.1 - 2.7 7.9 56.0 3.2 7.6 56.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DcuA_DcuB PF03605.14 CDI87481.1 - 3.7 6.4 13.7 4.6 6.0 13.7 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Presenilin PF01080.17 CDI87481.1 - 4.7 5.9 25.5 6.4 5.4 25.5 1.2 1 0 0 1 1 1 0 Presenilin Peroxin-3 PF04882.12 CDI87481.1 - 5.3 5.9 24.4 8 5.3 24.4 1.3 1 0 0 1 1 1 0 Peroxin-3 FHIPEP PF00771.20 CDI87481.1 - 5.4 5.4 16.4 6 5.2 16.4 1.2 1 0 0 1 1 1 0 FHIPEP family DUF4045 PF13254.6 CDI87481.1 - 5.9 6.4 27.9 6.9 6.2 27.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SART-1 PF03343.13 CDI87481.1 - 7.9 4.9 27.4 9.6 4.6 27.4 1.0 1 0 0 1 1 1 0 SART-1 family DUF2079 PF09852.9 CDI87481.1 - 8.5 5.1 11.4 11 4.8 11.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) Utp14 PF04615.13 CDI87484.1 - 0.64 8.5 28.6 0.75 8.3 28.6 1.2 1 0 0 1 1 1 0 Utp14 protein TrkA_N PF02254.18 CDI87484.1 - 9.7 6.5 9.0 1.6 9.0 4.0 2.1 1 1 0 1 1 1 0 TrkA-N domain Pex14_N PF04695.13 CDI87485.1 - 0.0024 18.5 8.7 0.0028 18.3 8.7 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 CDI87485.1 - 0.11 12.1 29.8 0.12 12.0 29.8 1.0 1 0 0 1 1 1 0 Spt20 family SARAF PF06682.12 CDI87485.1 - 0.13 11.9 10.5 0.13 11.9 10.5 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4834 PF16118.5 CDI87485.1 - 0.29 12.1 10.5 0.29 12.1 10.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2722 PF10846.8 CDI87485.1 - 0.36 9.7 23.1 0.4 9.6 23.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) UPF0560 PF10577.9 CDI87485.1 - 0.97 7.9 15.0 1.1 7.7 15.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF3729 PF12526.8 CDI87485.1 - 1 10.9 4.8 1.2 10.7 4.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3729) DUF3381 PF11861.8 CDI87485.1 - 1.3 8.8 11.2 1.3 8.8 11.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) EOS1 PF12326.8 CDI87485.1 - 1.3 8.9 3.4 1.4 8.8 3.4 1.1 1 0 0 1 1 1 0 N-glycosylation protein BRF1 PF07741.13 CDI87485.1 - 1.4 9.3 11.0 1.5 9.2 11.0 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain RED_N PF07808.13 CDI87485.1 - 1.9 8.0 12.7 2.1 7.9 12.7 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region TERB2 PF15101.6 CDI87485.1 - 2.6 8.0 13.8 2.6 8.0 13.8 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Med15 PF09606.10 CDI87485.1 - 3.1 6.4 25.0 3.2 6.3 25.0 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal EPL1 PF10513.9 CDI87485.1 - 3.3 8.1 11.7 3.6 7.9 11.7 1.0 1 0 0 1 1 1 0 Enhancer of polycomb-like TFIIA PF03153.13 CDI87485.1 - 4 7.3 26.8 4.6 7.1 26.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF702 PF05142.12 CDI87485.1 - 4.4 7.8 13.0 4.8 7.7 13.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) USP8_interact PF08941.10 CDI87485.1 - 4.6 7.0 11.7 4.6 7.0 11.7 1.1 1 0 0 1 1 1 0 USP8 interacting Suf PF05843.14 CDI87485.1 - 5.4 6.9 12.4 4.9 7.0 12.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3464 PF11947.8 CDI87485.1 - 5.7 6.7 8.9 6.7 6.5 8.9 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 eIF-3_zeta PF05091.12 CDI87485.1 - 6.3 5.7 14.6 6.5 5.6 14.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3371 PF11851.8 CDI87485.1 - 6.7 7.8 12.1 7.1 7.7 12.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Roughex PF06020.11 CDI87485.1 - 6.9 5.7 16.0 7.5 5.5 16.0 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Connexin PF00029.19 CDI87485.1 - 7.6 6.2 6.6 7.2 6.3 6.6 1.0 1 0 0 1 1 1 0 Connexin DUF4242 PF14026.6 CDI87485.1 - 9.2 6.5 8.4 13 6.0 8.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4242) MMR1 PF08505.10 CDI87485.1 - 9.6 6.4 13.5 9.8 6.4 13.5 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Plasmodium_Vir PF05795.11 CDI87487.1 - 0.19 11.1 0.3 0.23 10.8 0.3 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RNA_pol_3_Rpc31 PF11705.8 CDI87487.1 - 0.7 10.1 5.8 1.4 9.1 5.8 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 T3SS_needle_E PF08988.10 CDI87487.1 - 1.3 9.2 12.1 5.2 7.3 2.3 3.5 2 1 1 3 3 3 0 Type III secretion system, cytoplasmic E component of needle MFS_1 PF07690.16 CDI87488.1 - 3.1e-15 55.9 34.1 1.6e-09 37.2 19.3 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CDI87488.1 - 4.9e-15 54.8 0.0 2.1e-14 52.7 0.0 2.0 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 CDI87488.1 - 1.1e-07 31.0 1.3 1.4e-05 24.2 0.0 2.8 3 0 0 3 3 3 2 Sugar (and other) transporter DUF2722 PF10846.8 CDI87488.1 - 0.0037 16.3 6.4 0.18 10.7 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) Vut_1 PF02592.15 CDI87488.1 - 0.026 14.8 0.2 0.026 14.8 0.2 3.1 3 0 0 3 3 3 0 Putative vitamin uptake transporter TFIIA PF03153.13 CDI87488.1 - 3.2 7.6 16.2 0.96 9.4 3.2 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit S4 PF01479.25 CDI87489.1 - 2.2e-12 46.5 0.4 2.2e-12 46.5 0.4 2.1 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 CDI87489.1 - 3.2e-06 28.0 1.2 5e-06 27.3 0.8 1.6 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain DOT1 PF08123.13 CDI87490.1 - 4.9e-05 23.0 0.0 9e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 EGF_2 PF07974.13 CDI87491.1 - 3.1e-18 65.8 183.9 0.0004 20.7 12.6 10.6 9 1 1 10 10 10 9 EGF-like domain AMA-1 PF02430.15 CDI87491.1 - 6.6e-15 55.0 0.1 2.2e-14 53.3 0.1 1.8 2 0 0 2 2 2 1 Apical membrane antigen 1 hEGF PF12661.7 CDI87491.1 - 2.9e-11 43.6 122.2 0.0061 17.2 8.6 12.0 11 0 0 11 11 11 9 Human growth factor-like EGF EGF PF00008.27 CDI87491.1 - 0.00043 20.5 23.1 0.00095 19.4 9.5 10.7 7 3 2 9 9 9 6 EGF-like domain MIT PF04212.18 CDI87491.1 - 0.03 14.4 0.0 0.068 13.2 0.0 1.5 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain ETRAMP PF09716.10 CDI87491.1 - 0.18 11.9 0.0 1.3 9.2 0.0 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Ank_2 PF12796.7 CDI87494.1 - 3.4e-37 126.9 3.0 2.8e-13 50.2 0.1 5.5 4 2 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI87494.1 - 4e-29 100.6 0.1 1.4e-05 25.6 0.0 7.3 5 2 2 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDI87494.1 - 2e-27 94.9 4.4 0.00013 22.2 0.0 7.3 4 2 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI87494.1 - 1e-25 86.9 0.2 0.032 14.8 0.0 9.5 9 0 0 9 9 9 8 Ankyrin repeat Ank PF00023.30 CDI87494.1 - 2e-19 69.1 0.8 0.08 13.4 0.0 9.8 10 0 0 10 10 10 6 Ankyrin repeat Thioredoxin_2 PF13098.6 CDI87495.1 - 0.017 15.5 0.0 0.026 15.0 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CDI87495.1 - 0.038 14.3 0.0 0.22 11.9 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin-like SPX PF03105.19 CDI87496.1 - 0.69 9.8 23.8 0.17 11.8 17.3 2.0 2 0 0 2 2 2 0 SPX domain PNISR PF15996.5 CDI87496.1 - 8.4 6.6 39.1 0.069 13.4 21.8 2.6 2 1 0 2 2 2 0 Arginine/serine-rich protein PNISR PAP1 PF08601.10 CDI87498.1 - 0.0067 16.2 2.4 0.0067 16.2 2.4 8.9 9 2 0 9 9 9 1 Transcription factor PAP1 Ric8 PF10165.9 CDI87498.1 - 0.64 9.0 35.5 0.29 10.1 15.3 3.9 3 0 0 3 3 3 0 Guanine nucleotide exchange factor synembryn tRNA_anti-codon PF01336.25 CDI87499.1 - 5.5e-06 26.3 0.0 9.7e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Activator_LAG-3 PF11498.8 CDI87499.1 - 6.2e-05 22.2 34.1 0.00065 18.8 16.8 2.6 2 0 0 2 2 2 2 Transcriptional activator LAG-3 RskA PF10099.9 CDI87499.1 - 0.00023 21.5 21.0 0.00023 21.5 21.0 5.6 2 2 3 5 5 2 1 Anti-sigma-K factor rskA Sporozoite_P67 PF05642.11 CDI87499.1 - 0.0024 16.1 4.7 0.0057 14.8 4.1 1.9 1 1 0 1 1 1 1 Sporozoite P67 surface antigen SR-25 PF10500.9 CDI87499.1 - 0.0059 16.3 15.8 0.053 13.1 7.8 3.3 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI87499.1 - 0.0068 16.0 7.2 0.0068 16.0 7.2 2.4 2 1 0 2 2 1 1 Spt20 family MecA PF05389.12 CDI87499.1 - 0.057 13.0 4.7 1.7 8.2 0.6 2.3 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) Mit_KHE1 PF10173.9 CDI87499.1 - 0.063 13.4 3.3 1.2 9.2 0.2 2.5 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related DUF4207 PF13904.6 CDI87499.1 - 0.074 12.7 25.1 0.064 12.9 2.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4207) RAB3GAP2_N PF14655.6 CDI87499.1 - 0.089 12.0 9.8 0.4 9.9 0.7 2.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus eIF-3_zeta PF05091.12 CDI87499.1 - 0.15 11.0 11.1 0.57 9.1 3.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_S49_N PF08496.10 CDI87499.1 - 0.18 11.9 8.0 2.7 8.0 0.8 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4611 PF15387.6 CDI87499.1 - 0.2 11.9 9.3 0.11 12.7 0.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) KGK PF08872.10 CDI87499.1 - 0.31 11.5 5.7 6.7 7.2 0.6 2.2 2 0 0 2 2 2 0 KGK domain DUF3381 PF11861.8 CDI87499.1 - 0.48 10.2 12.9 3.2 7.5 5.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) RPA43_OB PF17875.1 CDI87499.1 - 0.55 10.9 5.5 2.9 8.5 0.9 2.6 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Gaa1 PF04114.14 CDI87499.1 - 0.76 8.7 7.4 2.3 7.2 2.2 2.1 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component Rpp20 PF12328.8 CDI87499.1 - 0.96 9.4 13.9 2.1 8.3 2.0 2.4 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P CENP-O PF09496.10 CDI87499.1 - 0.99 9.3 8.1 0.69 9.8 1.2 2.3 2 0 0 2 2 2 0 Cenp-O kinetochore centromere component PRC2_HTH_1 PF18118.1 CDI87499.1 - 1 10.2 7.0 6 7.7 0.2 2.9 3 0 0 3 3 2 0 Polycomb repressive complex 2 tri-helical domain Mus7 PF09462.10 CDI87499.1 - 1.4 7.7 11.8 1.8 7.4 2.0 2.1 2 0 0 2 2 2 0 Mus7/MMS22 family V_ATPase_I PF01496.19 CDI87499.1 - 1.5 6.7 7.2 1.2 7.0 0.8 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family RLL PF10036.9 CDI87499.1 - 1.9 8.3 21.1 0.57 10.0 2.7 2.4 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein TERB2 PF15101.6 CDI87499.1 - 2.1 8.4 20.3 0.54 10.3 1.8 2.8 3 0 0 3 3 3 0 Telomere-associated protein TERB2 Plasmodium_Vir PF05795.11 CDI87499.1 - 2.4 7.5 6.8 0.63 9.4 0.5 2.0 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Rsc14 PF08586.10 CDI87499.1 - 2.7 8.9 9.0 11 6.9 0.5 2.4 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit TFB6 PF17110.5 CDI87499.1 - 2.8 7.6 6.3 16 5.2 0.3 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH CNOT1_HEAT PF16418.5 CDI87499.1 - 2.9 8.0 17.0 1.8 8.6 6.3 2.3 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 HEAT repeat dsDNA_bind PF01984.20 CDI87499.1 - 3.2 8.1 29.8 1.4 9.2 4.8 2.6 2 0 0 2 2 2 0 Double-stranded DNA-binding domain DUF2681 PF10883.8 CDI87499.1 - 3.6 8.1 26.3 4 7.9 5.8 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Roughex PF06020.11 CDI87499.1 - 3.9 6.5 17.3 2.2 7.3 6.4 2.3 2 0 0 2 2 2 0 Drosophila roughex protein P5-ATPase PF12409.8 CDI87499.1 - 4.5 7.4 8.0 7.6 6.7 0.3 2.7 3 0 0 3 3 3 0 P5-type ATPase cation transporter Sec62 PF03839.16 CDI87499.1 - 4.5 6.7 7.0 10 5.5 1.2 2.4 2 0 0 2 2 2 0 Translocation protein Sec62 RNA_pol_Rbc25 PF08292.12 CDI87499.1 - 5 7.4 10.0 16 5.7 2.3 2.5 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 Kin17_mid PF10357.9 CDI87499.1 - 6.2 6.7 13.8 8.8 6.3 4.7 2.2 2 0 0 2 2 2 0 Domain of Kin17 curved DNA-binding protein G0-G1_switch_2 PF15103.6 CDI87499.1 - 7 7.1 12.6 12 6.4 2.9 2.8 2 0 0 2 2 2 0 G0/G1 switch protein 2 RAP1 PF07218.11 CDI87499.1 - 7.9 4.6 7.5 17 3.5 7.5 1.5 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4834 PF16118.5 CDI87499.1 - 9 7.3 21.2 3.7 8.6 2.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Sec16 PF12932.7 CDI87499.1 - 9.2 6.9 8.7 1.9 9.1 0.3 2.9 3 0 0 3 3 2 0 Vesicle coat trafficking protein Sec16 mid-region NST1 PF13945.6 CDI87500.1 - 0.054 13.6 14.7 0.066 13.3 14.7 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator PIEZO PF15917.5 CDI87500.1 - 0.12 11.8 7.0 0.11 11.9 7.0 1.2 1 0 0 1 1 1 0 Piezo Spt20 PF12090.8 CDI87500.1 - 0.19 11.3 26.7 0.21 11.2 26.7 1.2 1 0 0 1 1 1 0 Spt20 family FAM76 PF16046.5 CDI87500.1 - 0.43 9.9 12.1 0.45 9.8 12.1 1.1 1 0 0 1 1 1 0 FAM76 protein PEHE PF15275.6 CDI87500.1 - 0.46 11.1 8.1 0.59 10.8 8.1 1.3 1 0 0 1 1 1 0 PEHE domain Draxin PF15550.6 CDI87500.1 - 2.1 8.2 12.9 2.3 8.0 12.9 1.1 1 0 0 1 1 1 0 Draxin PHC2_SAM_assoc PF16616.5 CDI87500.1 - 2.2 9.1 17.8 2.7 8.8 17.8 1.3 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 DUF4638 PF15472.6 CDI87500.1 - 2.6 7.7 7.4 2.5 7.7 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) PNISR PF15996.5 CDI87500.1 - 2.8 8.2 17.2 3.2 8.0 17.2 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR FAM60A PF15396.6 CDI87500.1 - 2.9 7.9 8.2 3 7.8 8.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF1387 PF07139.11 CDI87500.1 - 2.9 7.5 12.6 3.1 7.4 12.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) MMR1 PF08505.10 CDI87500.1 - 2.9 8.1 18.2 3.1 8.0 18.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein MCM_bind PF09739.9 CDI87500.1 - 4.9 5.5 11.5 5.2 5.4 11.5 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Roughex PF06020.11 CDI87500.1 - 5 6.1 13.2 6.2 5.8 13.2 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Lin-8 PF03353.15 CDI87500.1 - 5.2 6.5 16.9 5.5 6.5 16.9 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Sec62 PF03839.16 CDI87500.1 - 5.5 6.4 7.3 5.5 6.4 7.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Utp14 PF04615.13 CDI87500.1 - 6.4 5.2 21.0 7.2 5.1 21.0 1.0 1 0 0 1 1 1 0 Utp14 protein MPM1 PF17234.2 CDI87500.1 - 6.7 6.9 11.6 8.2 6.7 11.6 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Band_3_cyto PF07565.13 CDI87500.1 - 7.1 6.3 9.2 7 6.4 9.2 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Neur_chan_memb PF02932.16 CDI87500.1 - 7.2 6.6 10.6 8.7 6.3 10.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Miga PF10265.9 CDI87500.1 - 7.5 5.4 14.9 7.8 5.3 14.9 1.0 1 0 0 1 1 1 0 Mitoguardin MAP65_ASE1 PF03999.12 CDI87500.1 - 7.8 5.1 20.7 8.5 4.9 20.7 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) NPR3 PF03666.13 CDI87500.1 - 8 5.1 12.5 8.6 5.0 12.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Membralin PF09746.9 CDI87500.1 - 9.8 5.1 5.4 9.6 5.1 5.4 1.1 1 0 0 1 1 1 0 Tumour-associated protein RskA PF10099.9 CDI87501.1 - 2.8e-07 31.0 13.1 2.8e-07 31.0 13.1 7.9 3 2 4 8 8 8 1 Anti-sigma-K factor rskA ThrE PF06738.12 CDI87501.1 - 0.00038 19.9 8.8 0.00038 19.9 8.8 2.6 2 1 0 2 2 2 1 Putative threonine/serine exporter O-antigen_lig PF13425.6 CDI87501.1 - 0.012 14.5 0.0 0.012 14.5 0.0 3.7 3 2 0 3 3 3 0 O-antigen ligase like membrane protein CD20 PF04103.15 CDI87501.1 - 0.016 15.3 2.3 0.016 15.3 2.3 4.4 1 1 2 3 3 3 0 CD20-like family Wzy_C PF04932.15 CDI87501.1 - 0.19 11.4 0.0 1 9.0 0.0 2.2 2 0 0 2 2 2 0 O-Antigen ligase Band_3_cyto PF07565.13 CDI87502.1 - 0.16 11.7 22.4 0.17 11.7 22.4 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain OATP PF03137.20 CDI87502.1 - 0.87 7.8 12.0 1.1 7.5 12.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family eIF-3_zeta PF05091.12 CDI87502.1 - 2.2 7.2 31.7 2.3 7.1 31.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CSG2 PF16965.5 CDI87502.1 - 3.1 6.6 14.0 3 6.7 14.0 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Pkinase_fungal PF17667.1 CDI87502.1 - 3.3 6.4 15.1 3.5 6.3 15.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase MMM1 PF10296.9 CDI87502.1 - 4 6.4 17.3 4.3 6.3 17.3 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Peptidase_S30 PF01577.16 CDI87502.1 - 4.4 6.9 26.3 4.9 6.7 26.3 1.2 1 0 0 1 1 1 0 Potyvirus P1 protease Dynamin_N PF00350.23 CDI87502.1 - 6.5 6.8 15.6 9.9 6.2 15.6 1.3 1 0 0 1 1 1 0 Dynamin family DUF3292 PF11696.8 CDI87502.1 - 8 4.7 29.8 8.4 4.6 29.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Folate_carrier PF01770.18 CDI87502.1 - 8.6 5.0 14.3 11 4.6 14.3 1.3 1 0 0 1 1 1 0 Reduced folate carrier LicD PF04991.13 CDI87502.1 - 8.9 6.4 12.8 9.4 6.3 12.8 1.1 1 0 0 1 1 1 0 LicD family Dynein_light PF01221.18 CDI87503.1 - 2.8e-06 27.6 0.1 4.6e-06 26.9 0.0 1.3 2 0 0 2 2 2 1 Dynein light chain type 1 DUF5101 PF17031.5 CDI87503.1 - 0.032 14.3 0.0 0.036 14.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5101) TFIIA PF03153.13 CDI87505.1 - 0.49 10.3 18.8 0.66 9.9 18.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GET2 PF08690.10 CDI87506.1 - 1.6 8.3 5.3 3.9 7.0 5.3 1.6 1 0 0 1 1 1 0 GET complex subunit GET2 Myc_N PF01056.18 CDI87508.1 - 0.29 11.0 14.0 0.34 10.8 14.0 1.1 1 0 0 1 1 1 0 Myc amino-terminal region LRIF1 PF15741.5 CDI87508.1 - 0.36 9.3 9.7 0.42 9.1 9.7 1.0 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 TLP-20 PF06088.11 CDI87508.1 - 2.4 8.0 14.8 4.1 7.3 0.0 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DHHW PF14286.6 CDI87508.1 - 3.5 6.9 12.5 4.3 6.6 12.5 1.2 1 0 0 1 1 1 0 DHHW protein CLN3 PF02487.17 CDI87508.1 - 5.1 6.0 6.5 6.8 5.6 6.5 1.2 1 0 0 1 1 1 0 CLN3 protein DUF2981 PF11200.8 CDI87508.1 - 5.8 6.6 8.6 6.6 6.4 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) XRN_M PF17846.1 CDI87508.1 - 7.8 5.3 10.1 8.6 5.2 10.1 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Fungus-induced PF10917.8 CDI87509.1 - 0.38 11.1 0.9 3.2 8.2 0.3 2.4 2 0 0 2 2 2 0 Fungus-induced protein DUF4079 PF13301.6 CDI87509.1 - 0.55 10.4 7.7 3.6 7.7 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4079) Med15 PF09606.10 CDI87509.1 - 0.91 8.1 34.8 1.1 7.8 34.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PPP4R2 PF09184.11 CDI87509.1 - 1.2 8.6 11.8 1.4 8.5 11.8 1.1 1 0 0 1 1 1 0 PPP4R2 Hamartin PF04388.12 CDI87509.1 - 1.3 7.6 17.0 1.6 7.3 17.0 1.0 1 0 0 1 1 1 0 Hamartin protein DUF2232 PF09991.9 CDI87509.1 - 1.7 7.8 4.9 1.5 7.9 3.1 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) TFIIA PF03153.13 CDI87509.1 - 1.7 8.6 38.8 2.2 8.2 38.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TMEM223 PF14640.6 CDI87509.1 - 1.7 8.8 5.4 3.9 7.6 0.2 2.4 1 1 0 2 2 2 0 Transmembrane protein 223 RskA PF10099.9 CDI87509.1 - 2.7 8.3 30.0 1.1e+02 3.0 30.0 2.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI87509.1 - 3 6.5 25.5 0.89 8.3 21.9 1.7 1 1 0 2 2 2 0 Presenilin CDK5_activator PF03261.15 CDI87509.1 - 4.8 6.6 16.6 5.7 6.4 16.6 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF2981 PF11200.8 CDI87509.1 - 5.7 6.6 9.7 8.8 6.0 9.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) C_Hendra PF16821.5 CDI87509.1 - 7.1 6.5 18.1 7.6 6.4 11.1 2.1 1 1 1 2 2 2 0 C protein from hendra and measles viruses DUF966 PF06136.13 CDI87509.1 - 7.4 6.2 22.4 9.3 5.8 22.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Ribosomal_60s PF00428.19 CDI87509.1 - 9.5 6.9 28.6 0.42 11.2 7.7 2.7 2 1 1 3 3 3 0 60s Acidic ribosomal protein NTP_transf_3 PF12804.7 CDI87511.1 - 0.016 15.6 2.7 0.018 15.4 1.5 1.6 2 0 0 2 2 2 0 MobA-like NTP transferase domain DUF1645 PF07816.11 CDI87511.1 - 0.024 15.2 8.7 0.024 15.2 8.7 4.3 3 1 1 4 4 3 0 Protein of unknown function (DUF1645) DUF3807 PF12720.7 CDI87511.1 - 0.033 14.5 75.7 0.039 14.2 12.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) Mpp10 PF04006.12 CDI87511.1 - 0.066 11.7 67.5 0.16 10.4 14.3 3.1 3 0 0 3 3 3 0 Mpp10 protein FAM76 PF16046.5 CDI87511.1 - 0.3 10.4 56.1 0.5 9.7 10.8 3.1 3 0 0 3 3 3 0 FAM76 protein DUF572 PF04502.13 CDI87511.1 - 0.62 9.6 58.0 0.44 10.1 31.9 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) LTV PF04180.14 CDI87511.1 - 0.87 9.3 52.1 0.3 10.8 8.1 3.1 3 0 0 3 3 3 0 Low temperature viability protein Presenilin PF01080.17 CDI87511.1 - 1.1 7.9 72.1 0.93 8.2 17.1 3.0 3 0 0 3 3 3 0 Presenilin MMR1 PF08505.10 CDI87511.1 - 1.5 9.0 70.9 3.1 8.0 9.6 3.2 3 0 0 3 3 3 0 Mitochondrial Myo2 receptor-related protein CCSAP PF15748.5 CDI87511.1 - 1.9 8.6 72.3 1.2 9.2 16.8 3.1 3 0 0 3 3 3 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 CDI87511.1 - 2.3 7.2 60.8 1.4 7.8 22.5 3.0 3 0 0 3 3 3 0 Solute carrier family 12 CAC1F_C PF16885.5 CDI87511.1 - 5.6 6.5 42.9 2 8.0 31.0 2.2 2 0 0 2 2 2 0 Voltage-gated calcium channel subunit alpha, C-term CobT PF06213.12 CDI87511.1 - 6.2 6.1 100.9 0.013 14.9 32.2 3.4 2 1 1 3 3 2 0 Cobalamin biosynthesis protein CobT DUF4746 PF15928.5 CDI87511.1 - 6.7 6.0 59.4 0.45 9.9 20.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4746) eIF-3_zeta PF05091.12 CDI87511.1 - 7.4 5.4 65.0 0.016 14.2 8.5 3.2 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Nop14 PF04147.12 CDI87511.1 - 7.6 4.6 59.7 1.6 6.8 23.1 3.0 3 0 0 3 3 3 0 Nop14-like family Trypan_PARP PF05887.11 CDI87512.1 - 1.1 9.3 18.3 0.076 13.0 0.9 2.5 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) AF-4 PF05110.13 CDI87514.1 - 0.00019 19.7 27.6 0.00019 19.7 27.6 2.0 1 1 1 2 2 2 1 AF-4 proto-oncoprotein DUF2828 PF11443.8 CDI87514.1 - 0.059 11.5 6.8 0.085 10.9 6.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) eIF-3_zeta PF05091.12 CDI87514.1 - 0.55 9.1 20.2 0.1 11.5 2.4 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spt20 PF12090.8 CDI87514.1 - 0.68 9.5 61.4 0.042 13.4 15.1 3.0 3 0 0 3 3 3 0 Spt20 family DUF3807 PF12720.7 CDI87514.1 - 3.2 8.0 30.2 0.31 11.3 5.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) GTP1_OBG PF01018.22 CDI87516.1 - 4.5e-24 84.8 12.4 6e-23 81.1 9.0 2.9 2 1 0 2 2 2 1 GTP1/OBG MMR_HSR1 PF01926.23 CDI87516.1 - 3.6e-06 27.0 0.0 1.6e-05 24.9 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDI87516.1 - 4.1e-05 23.2 0.0 0.0004 20.0 0.0 2.4 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain Arf PF00025.21 CDI87516.1 - 0.0013 18.3 0.0 0.0028 17.1 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 CDI87516.1 - 0.0026 17.6 0.0 0.0068 16.2 0.0 1.7 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein TOBE_3 PF12857.7 CDI87516.1 - 0.025 14.5 2.4 0.087 12.8 2.4 2.0 1 0 0 1 1 1 0 TOBE-like domain RsgA_GTPase PF03193.16 CDI87516.1 - 0.077 12.9 0.2 0.29 11.0 0.0 2.1 3 0 0 3 3 3 0 RsgA GTPase DUF1967 PF09269.11 CDI87516.1 - 0.23 11.4 0.0 0.79 9.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1967) Gtr1_RagA PF04670.12 CDI87516.1 - 0.28 10.5 0.0 0.51 9.7 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region 3-alpha PF03475.14 CDI87516.1 - 4.1 7.3 5.6 1.1 9.2 1.4 2.2 2 0 0 2 2 2 0 3-alpha domain IMS PF00817.20 CDI87518.1 - 1.3e-19 70.7 0.5 1.1e-08 35.2 0.0 3.2 2 1 1 3 3 3 2 impB/mucB/samB family IMS_C PF11799.8 CDI87518.1 - 2e-11 44.6 0.4 9e-11 42.5 0.4 2.0 1 1 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 CDI87518.1 - 0.00019 21.5 0.0 0.00046 20.4 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif SWIRM-assoc_2 PF16496.5 CDI87518.1 - 0.054 12.4 6.4 0.097 11.5 6.4 1.3 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Cdd1 PF11731.8 CDI87518.1 - 0.11 12.8 0.0 0.27 11.5 0.0 1.6 1 0 0 1 1 1 0 Pathogenicity locus Pneumo_att_G PF05539.11 CDI87518.1 - 3.7 7.0 8.4 9.3 5.7 8.4 1.6 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G PTS_IIB PF02302.17 CDI87518.1 - 4.2 8.1 5.7 1.4 9.6 0.2 2.8 3 0 0 3 3 3 0 PTS system, Lactose/Cellobiose specific IIB subunit Folate_rec PF03024.14 CDI87519.1 - 1.5e-10 41.2 5.1 2.3e-10 40.6 5.1 1.3 1 0 0 1 1 1 1 Folate receptor family DUF1828 PF08861.10 CDI87519.1 - 0.17 12.2 0.2 0.3 11.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF1828 MORN PF02493.20 CDI87520.1 - 7.3e-12 44.5 9.9 0.00045 19.9 0.0 5.5 5 0 0 5 5 5 4 MORN repeat AP2 PF00847.20 CDI87520.1 - 0.14 12.4 0.2 0.33 11.2 0.2 1.5 1 0 0 1 1 1 0 AP2 domain BTK PF00779.19 CDI87522.1 - 0.024 14.5 6.6 1.7 8.6 0.7 2.5 2 0 0 2 2 2 0 BTK motif FAM60A PF15396.6 CDI87522.1 - 5.5 6.9 9.2 12 5.9 9.2 1.6 1 0 0 1 1 1 0 Protein Family FAM60A Activator_LAG-3 PF11498.8 CDI87525.1 - 0.00019 20.5 54.1 0.023 13.7 43.1 2.6 2 0 0 2 2 2 2 Transcriptional activator LAG-3 Lin-8 PF03353.15 CDI87525.1 - 0.023 14.3 26.7 0.024 14.2 16.7 2.4 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist MCU PF04678.13 CDI87525.1 - 3.6 7.6 13.2 1.7 8.7 6.8 2.7 2 0 0 2 2 2 0 Mitochondrial calcium uniporter SR-25 PF10500.9 CDI87526.1 - 0.00019 21.1 4.9 0.00019 21.1 4.9 4.3 6 0 0 6 6 6 1 Nuclear RNA-splicing-associated protein LCD1 PF09798.9 CDI87526.1 - 0.24 9.9 0.0 0.24 9.9 0.0 4.3 4 1 0 4 4 4 0 DNA damage checkpoint protein DUF2722 PF10846.8 CDI87527.1 - 0.091 11.7 31.8 0.51 9.2 2.9 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) DUF4834 PF16118.5 CDI87527.1 - 5.7 8.0 0.0 5.7 8.0 0.0 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) SUIM_assoc PF16619.5 CDI87527.1 - 6.2 7.0 57.6 1.4 9.0 8.5 4.7 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI87528.1 - 0.0015 18.9 8.7 0.0015 18.9 8.7 11.5 1 1 5 7 7 7 2 Anti-sigma-K factor rskA UIM PF02809.20 CDI87529.1 - 0.0073 16.2 0.2 0.018 14.9 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin interaction motif DDHD PF02862.17 CDI87529.1 - 0.26 11.4 4.8 0.28 11.3 4.8 1.2 1 0 0 1 1 1 0 DDHD domain TFIIA PF03153.13 CDI87529.1 - 0.32 11.0 16.4 0.31 11.0 16.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SPX PF03105.19 CDI87529.1 - 0.86 9.5 6.9 1.1 9.1 6.9 1.1 1 0 0 1 1 1 0 SPX domain GREB1 PF15782.5 CDI87529.1 - 3.7 4.5 10.0 4.3 4.3 10.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Band_3_cyto PF07565.13 CDI87530.1 - 0.0026 17.6 12.9 0.0026 17.6 12.9 6.6 6 2 1 7 7 7 1 Band 3 cytoplasmic domain NAM-associated PF14303.6 CDI87530.1 - 0.058 14.1 0.1 0.058 14.1 0.1 8.4 5 4 2 7 7 7 0 No apical meristem-associated C-terminal domain RR_TM4-6 PF06459.12 CDI87531.1 - 0.91 9.3 31.0 1.1 9.1 31.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 CDI87531.1 - 1 7.6 29.5 1.2 7.3 29.5 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.6 CDI87531.1 - 1.4 8.9 25.2 1.6 8.7 25.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A PAT1 PF09770.9 CDI87531.1 - 1.6 6.9 52.7 1.7 6.8 52.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NPR3 PF03666.13 CDI87531.1 - 2 7.1 28.6 2.2 7.0 28.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Hid1 PF12722.7 CDI87531.1 - 3.9 5.5 30.0 4.5 5.3 30.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4045 PF13254.6 CDI87531.1 - 3.9 7.0 24.1 4.5 6.8 24.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Rtf2 PF04641.12 CDI87531.1 - 4.4 6.6 24.6 6.9 5.9 24.6 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger Raftlin PF15250.6 CDI87531.1 - 4.5 5.9 24.8 4.8 5.8 24.8 1.0 1 0 0 1 1 1 0 Raftlin Presenilin PF01080.17 CDI87531.1 - 5.9 5.5 39.4 6.6 5.4 39.4 1.0 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 CDI87531.1 - 6 5.6 26.8 7 5.4 26.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter PNISR PF15996.5 CDI87531.1 - 6.3 7.0 33.8 8.5 6.6 33.8 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF1387 PF07139.11 CDI87531.1 - 7.3 6.2 28.9 10 5.8 28.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) LAP1C PF05609.12 CDI87531.1 - 7.8 5.5 31.2 9.4 5.2 31.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SLC12 PF03522.15 CDI87531.1 - 9.1 5.2 34.9 10 5.0 34.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 HCO3_cotransp PF00955.21 CDI87531.1 - 9.4 4.9 14.3 11 4.7 14.3 1.1 1 0 0 1 1 1 0 HCO3- transporter family SPX PF03105.19 CDI87532.1 - 0.42 10.5 18.3 0.68 9.8 18.3 1.5 1 0 0 1 1 1 0 SPX domain CDC27 PF09507.10 CDI87532.1 - 1.4 8.2 27.1 2.6 7.3 27.1 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 AF-4 PF05110.13 CDI87532.1 - 2.2 6.3 29.3 2.7 6.0 29.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Hid1 PF12722.7 CDI87532.1 - 3.1 5.8 23.1 3.9 5.5 23.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SOG2 PF10428.9 CDI87532.1 - 7.4 5.6 22.8 12 5.0 22.8 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Vac7 PF12751.7 CDI87532.1 - 8.8 5.7 18.3 12 5.2 18.3 1.2 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 SUIM_assoc PF16619.5 CDI87533.1 - 9.3e-06 25.6 1.3 0.0016 18.4 4.1 22.1 14 7 3 17 17 17 3 Unstructured region C-term to UIM in Ataxin3 MAP7 PF05672.11 CDI87534.1 - 0.031 14.0 20.9 0.037 13.7 20.9 1.0 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family Peptidase_S49_N PF08496.10 CDI87534.1 - 0.072 13.1 12.4 0.089 12.9 12.4 1.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Connexin PF00029.19 CDI87534.1 - 0.086 12.6 7.1 0.091 12.5 7.1 1.0 1 0 0 1 1 1 0 Connexin FAM176 PF14851.6 CDI87534.1 - 0.1 12.3 5.8 0.12 12.0 5.8 1.1 1 0 0 1 1 1 0 FAM176 family Nucleoside_tran PF01733.18 CDI87534.1 - 0.12 11.7 2.2 0.13 11.6 2.2 1.0 1 0 0 1 1 1 0 Nucleoside transporter TFB6 PF17110.5 CDI87534.1 - 0.19 11.5 5.0 0.2 11.4 5.0 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH GDE_N PF12439.8 CDI87534.1 - 0.28 10.6 6.8 0.36 10.2 6.8 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme N terminal DUF4446 PF14584.6 CDI87534.1 - 0.28 11.2 4.8 0.31 11.0 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) SID-1_RNA_chan PF13965.6 CDI87534.1 - 0.28 9.5 4.2 0.31 9.4 4.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EIF4E-T PF10477.9 CDI87534.1 - 0.32 9.8 24.4 0.34 9.7 24.4 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E eIF-3_zeta PF05091.12 CDI87534.1 - 0.37 9.7 15.2 0.37 9.7 15.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SpoIIP PF07454.11 CDI87534.1 - 0.43 10.0 12.2 0.46 9.9 12.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.8 CDI87534.1 - 0.55 9.0 9.4 0.67 8.7 9.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Folate_carrier PF01770.18 CDI87534.1 - 0.59 8.8 5.0 0.65 8.7 5.0 1.1 1 0 0 1 1 1 0 Reduced folate carrier DUF2126 PF09899.9 CDI87534.1 - 0.6 8.1 9.4 0.66 8.0 9.4 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) BAF1_ABF1 PF04684.13 CDI87534.1 - 0.69 8.9 15.2 0.79 8.7 15.2 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor R_equi_Vir PF05526.11 CDI87534.1 - 0.71 9.7 9.1 0.98 9.3 9.1 1.2 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein SLC12 PF03522.15 CDI87534.1 - 0.75 8.8 12.0 0.77 8.7 12.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 CDI87534.1 - 0.8 9.7 8.5 0.79 9.7 8.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Ctr PF04145.15 CDI87534.1 - 0.8 10.3 6.4 0.95 10.1 6.4 1.1 1 0 0 1 1 1 0 Ctr copper transporter family V_ATPase_I PF01496.19 CDI87534.1 - 0.82 7.5 13.9 0.91 7.4 13.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2232 PF09991.9 CDI87534.1 - 0.84 8.8 5.2 1 8.5 5.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) OATP PF03137.20 CDI87534.1 - 0.98 7.6 5.0 1.1 7.5 5.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CobT PF06213.12 CDI87534.1 - 1.1 8.6 23.5 1.3 8.4 23.5 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FliP PF00813.20 CDI87534.1 - 1.1 9.1 7.7 1.4 8.8 7.7 1.2 1 0 0 1 1 1 0 FliP family CLN3 PF02487.17 CDI87534.1 - 1.1 8.2 9.3 1.2 8.1 9.3 1.1 1 0 0 1 1 1 0 CLN3 protein CSG2 PF16965.5 CDI87534.1 - 1.1 8.1 5.4 1 8.2 5.4 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator EOS1 PF12326.8 CDI87534.1 - 1.2 9.0 5.7 1.4 8.8 5.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein YABBY PF04690.13 CDI87534.1 - 1.2 9.7 11.3 1.4 9.5 11.3 1.1 1 0 0 1 1 1 0 YABBY protein CD20 PF04103.15 CDI87534.1 - 1.3 9.1 3.6 2.5 8.2 3.6 1.6 1 1 0 1 1 1 0 CD20-like family PIP5K PF01504.18 CDI87534.1 - 1.3 8.2 10.2 1.5 8.0 10.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Pex14_N PF04695.13 CDI87534.1 - 1.6 9.4 25.6 2.3 8.9 25.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Serinc PF03348.15 CDI87534.1 - 1.6 7.5 8.1 1.8 7.4 8.1 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF1980 PF09323.10 CDI87534.1 - 1.7 8.5 9.4 1.8 8.5 9.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) CCB2_CCB4 PF11152.8 CDI87534.1 - 1.9 7.8 9.5 1.3 8.3 8.5 1.3 1 1 0 1 1 1 0 Cofactor assembly of complex C subunit B, CCB2/CCB4 Peptidase_S15 PF02129.18 CDI87534.1 - 2.2 7.8 14.3 2.7 7.5 14.3 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Ureide_permease PF07168.11 CDI87534.1 - 2.2 6.9 5.9 2.6 6.7 5.9 1.2 1 0 0 1 1 1 0 Ureide permease TERB2 PF15101.6 CDI87534.1 - 2.4 8.2 18.1 3 7.9 18.1 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 RskA PF10099.9 CDI87534.1 - 2.8 8.2 33.1 9.2 6.5 33.1 1.7 1 1 0 1 1 1 0 Anti-sigma-K factor rskA RR_TM4-6 PF06459.12 CDI87534.1 - 3 7.6 13.3 3.3 7.4 13.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Band_3_cyto PF07565.13 CDI87534.1 - 3.1 7.5 13.3 3.4 7.4 13.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Sec62 PF03839.16 CDI87534.1 - 3.3 7.2 8.6 3.7 7.0 8.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 TFIIA PF03153.13 CDI87534.1 - 3.5 7.5 44.2 4.3 7.2 44.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI87534.1 - 3.6 5.8 28.6 3.9 5.6 28.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 CDI87534.1 - 4.5 5.9 18.3 5.1 5.8 18.3 1.0 1 0 0 1 1 1 0 Presenilin O-antigen_lig PF13425.6 CDI87534.1 - 4.8 5.9 4.6 5.3 5.7 4.6 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PigN PF04987.14 CDI87534.1 - 4.9 5.9 5.3 5.7 5.7 5.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) LMBR1 PF04791.16 CDI87534.1 - 5.6 5.8 9.1 5.6 5.7 9.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Neur_chan_memb PF02932.16 CDI87534.1 - 5.6 6.9 10.1 6.1 6.8 10.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM199X PF15814.5 CDI87534.1 - 5.7 5.9 10.4 7.8 5.4 10.4 1.3 1 0 0 1 1 1 0 Protein family FAM199X MDM10 PF12519.8 CDI87534.1 - 5.9 5.6 10.6 6.2 5.6 10.6 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DDHD PF02862.17 CDI87534.1 - 6.1 6.9 14.0 7.1 6.7 14.0 1.1 1 0 0 1 1 1 0 DDHD domain HCO3_cotransp PF00955.21 CDI87534.1 - 6.3 5.5 5.4 6.6 5.4 5.4 1.0 1 0 0 1 1 1 0 HCO3- transporter family Activator_LAG-3 PF11498.8 CDI87534.1 - 7.1 5.5 53.2 8.7 5.2 53.2 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 HemX PF04375.14 CDI87534.1 - 7.2 5.8 37.4 8.7 5.5 37.4 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Exonuc_VII_L PF02601.15 CDI87534.1 - 7.3 6.1 20.8 8.9 5.8 20.8 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Suf PF05843.14 CDI87534.1 - 8 6.4 19.4 9.8 6.1 19.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4175 PF13779.6 CDI87534.1 - 8.1 4.2 37.5 10 3.9 37.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ALMT PF11744.8 CDI87534.1 - 8.2 5.1 10.2 8.7 5.0 10.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter T2SSC PF11356.8 CDI87534.1 - 8.4 6.3 16.1 11 5.9 16.1 1.3 1 0 0 1 1 1 0 Type II secretion system protein C DUF572 PF04502.13 CDI87535.1 - 5.2 6.6 4.9 6.1 6.4 4.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Endomucin PF07010.12 CDI87535.1 - 6.4 6.7 22.6 8.1 6.3 22.6 1.2 1 0 0 1 1 1 0 Endomucin Ribosomal_L30 PF00327.20 CDI87536.1 - 0.22 11.4 0.2 0.38 10.7 0.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L30p/L7e Ndc1_Nup PF09531.10 CDI87536.1 - 2.3 6.8 5.2 2.8 6.5 5.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AUX_IAA PF02309.16 CDI87536.1 - 2.8 7.7 7.9 0.54 10.1 4.0 1.7 1 1 1 2 2 2 0 AUX/IAA family SRP-alpha_N PF04086.13 CDI87536.1 - 3.6 7.4 6.1 4.7 7.1 6.1 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Spt20 PF12090.8 CDI87536.1 - 4.7 6.8 7.3 6.4 6.3 7.3 1.2 1 0 0 1 1 1 0 Spt20 family Lin-8 PF03353.15 CDI87537.1 - 0.0085 15.7 12.2 0.0085 15.7 12.2 4.6 2 1 2 4 4 4 1 Ras-mediated vulval-induction antagonist Stk19 PF10494.9 CDI87538.1 - 0.00025 20.8 9.3 0.00025 20.8 9.3 2.0 3 1 0 3 3 3 1 Serine-threonine protein kinase 19 SUIM_assoc PF16619.5 CDI87538.1 - 0.014 15.5 1.6 0.014 15.5 1.6 7.8 5 1 1 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 CDI87539.1 - 6.4e-18 65.1 0.1 6.4e-18 65.1 0.1 2.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI87539.1 - 1.3e-10 41.0 0.3 1.3e-10 41.0 0.3 2.5 3 0 0 3 3 3 1 Protein tyrosine kinase N6_N4_Mtase PF01555.18 CDI87539.1 - 0.98 9.1 7.5 33 4.1 7.5 2.5 1 1 0 1 1 1 0 DNA methylase SpoIIP PF07454.11 CDI87540.1 - 0.45 9.9 12.9 0.45 9.9 12.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CPSF100_C PF13299.6 CDI87540.1 - 0.65 10.2 9.5 0.76 9.9 9.5 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF3292 PF11696.8 CDI87540.1 - 0.65 8.3 14.1 0.78 8.0 14.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Tim54 PF11711.8 CDI87540.1 - 0.83 8.4 12.6 0.97 8.1 12.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4407 PF14362.6 CDI87540.1 - 0.88 8.9 13.7 0.89 8.8 13.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) STAC2_u1 PF16664.5 CDI87540.1 - 0.93 10.0 10.8 1.2 9.6 10.8 1.2 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 RR_TM4-6 PF06459.12 CDI87540.1 - 1 9.2 13.5 0.99 9.2 13.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pal1 PF08316.11 CDI87540.1 - 1.1 10.0 6.5 1.4 9.7 6.5 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein eIF-3_zeta PF05091.12 CDI87540.1 - 1.2 8.0 16.4 1.2 8.1 16.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI87540.1 - 1.2 7.8 17.9 1.3 7.8 17.9 1.0 1 0 0 1 1 1 0 Presenilin DDHD PF02862.17 CDI87540.1 - 1.6 8.8 12.2 1.6 8.8 12.2 1.1 1 0 0 1 1 1 0 DDHD domain EIIBC-GUT_N PF03612.14 CDI87540.1 - 1.7 8.3 10.4 2.3 7.9 10.4 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus FAM60A PF15396.6 CDI87540.1 - 1.9 8.4 11.0 2.1 8.3 11.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Membralin PF09746.9 CDI87540.1 - 2.1 7.3 7.3 2.1 7.3 7.3 1.0 1 0 0 1 1 1 0 Tumour-associated protein Band_3_cyto PF07565.13 CDI87540.1 - 2.2 8.0 15.9 2.6 7.8 15.9 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain AIF_C PF14721.6 CDI87540.1 - 2.6 8.4 9.5 3.8 7.9 9.5 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term SLC12 PF03522.15 CDI87540.1 - 2.7 6.9 14.4 2.8 6.9 14.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 EOS1 PF12326.8 CDI87540.1 - 3.5 7.5 6.3 3.8 7.4 6.3 1.2 1 0 0 1 1 1 0 N-glycosylation protein AAA_23 PF13476.6 CDI87540.1 - 3.7 8.0 18.5 3.4 8.1 18.5 1.1 1 0 0 1 1 1 0 AAA domain DUF2126 PF09899.9 CDI87540.1 - 5.5 4.9 12.0 5.7 4.9 12.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) HCO3_cotransp PF00955.21 CDI87540.1 - 6.9 5.4 5.3 7.5 5.2 5.3 1.0 1 0 0 1 1 1 0 HCO3- transporter family Ureide_permease PF07168.11 CDI87540.1 - 9.2 4.9 8.8 9.9 4.8 8.8 1.0 1 0 0 1 1 1 0 Ureide permease Gti1_Pac2 PF09729.9 CDI87540.1 - 9.7 6.2 13.0 12 6.0 13.0 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF1980 PF09323.10 CDI87540.1 - 9.9 6.0 10.5 10 6.0 10.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) VPS13_C PF16909.5 CDI87541.1 - 9.8e-25 87.4 1.2 1e-19 71.0 0.2 3.2 2 1 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 CDI87541.1 - 4.8e-05 23.6 0.0 0.00015 22.0 0.0 1.8 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain PPS_PS PF02006.16 CDI87541.1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphopantothenate/pantothenate synthetase VPS13 PF16908.5 CDI87542.1 - 2e-09 37.6 0.0 1.2e-07 31.8 0.0 3.2 2 1 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 CDI87542.1 - 0.017 15.2 0.0 0.23 11.6 0.0 2.8 1 1 0 1 1 1 0 N-terminal region of Chorein or VPS13 Rhomboid PF01694.22 CDI87544.1 - 4e-25 88.6 14.8 8.1e-25 87.6 14.8 1.5 1 0 0 1 1 1 1 Rhomboid family DUF1751 PF08551.10 CDI87544.1 - 0.039 14.5 0.1 0.039 14.5 0.1 2.0 3 0 0 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) DER1 PF04511.15 CDI87544.1 - 0.042 13.8 1.4 0.078 12.9 1.4 1.6 1 1 0 1 1 1 0 Der1-like family WD40 PF00400.32 CDI87545.1 - 1.6e-10 41.3 9.0 0.00029 21.6 0.7 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI87545.1 - 0.0047 17.2 0.0 18 5.7 0.0 4.7 4 1 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain MPS2 PF17060.5 CDI87545.1 - 0.52 9.5 6.4 0.91 8.7 6.4 1.3 1 0 0 1 1 1 0 Monopolar spindle protein 2 NAP PF00956.18 CDI87545.1 - 4.6 6.3 9.5 9.1 5.4 9.5 1.4 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) Exonuc_VII_L PF02601.15 CDI87546.1 - 0.21 11.2 29.2 0.3 10.6 29.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Presenilin PF01080.17 CDI87546.1 - 0.4 9.4 17.0 0.56 8.9 17.0 1.4 1 0 0 1 1 1 0 Presenilin DUF4386 PF14329.6 CDI87546.1 - 0.48 10.2 7.8 0.5 10.2 1.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4386) Med15 PF09606.10 CDI87546.1 - 5.2 5.6 51.1 7.3 5.1 51.1 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Paramyxo_ncap PF00973.19 CDI87546.1 - 5.7 5.7 19.2 7.7 5.3 19.2 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein GHMP_kinases_N PF00288.26 CDI87546.1 - 6.4 7.1 12.2 7.9 6.8 1.1 3.2 3 0 0 3 3 3 0 GHMP kinases N terminal domain DUF4148 PF13663.6 CDI87546.1 - 7.5 6.8 19.7 0.18 12.0 2.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4148) DUF4770 PF15994.5 CDI87546.1 - 9.4 6.4 24.6 17 5.6 24.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) RskA PF10099.9 CDI87547.1 - 2.2e-05 24.8 10.7 2.2e-05 24.8 10.7 2.2 1 1 1 2 2 1 1 Anti-sigma-K factor rskA Peptidase_S49_N PF08496.10 CDI87547.1 - 0.0073 16.4 12.3 0.014 15.4 12.3 1.4 1 0 0 1 1 1 1 Peptidase family S49 N-terminal Glyco_transf_49 PF13896.6 CDI87547.1 - 0.013 14.8 5.1 0.017 14.5 5.1 1.1 1 0 0 1 1 1 0 Glycosyl-transferase for dystroglycan EIF4E-T PF10477.9 CDI87547.1 - 0.016 14.1 13.4 0.016 14.1 13.4 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E TFIIA PF03153.13 CDI87547.1 - 0.017 15.1 40.2 0.02 14.9 40.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 CDI87547.1 - 0.044 12.8 12.9 0.047 12.7 12.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PRCC PF10253.9 CDI87547.1 - 0.049 14.4 22.3 0.061 14.1 22.3 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF572 PF04502.13 CDI87547.1 - 0.18 11.4 11.8 0.22 11.1 11.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Ribosomal_S2 PF00318.20 CDI87547.1 - 0.22 10.7 6.0 0.31 10.2 6.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S2 DUF4834 PF16118.5 CDI87547.1 - 0.33 12.0 13.8 0.57 11.2 13.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TERB2 PF15101.6 CDI87547.1 - 0.47 10.5 17.7 0.79 9.7 17.7 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SpoVR PF04293.13 CDI87547.1 - 0.61 8.7 13.7 0.43 9.2 12.3 1.4 2 0 0 2 2 2 0 SpoVR like protein DUF1980 PF09323.10 CDI87547.1 - 0.67 9.9 5.9 0.91 9.4 5.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF3086 PF11285.8 CDI87547.1 - 0.93 8.5 14.8 1.4 7.9 14.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) RR_TM4-6 PF06459.12 CDI87547.1 - 1.1 9.1 17.1 1.4 8.6 17.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LMBR1 PF04791.16 CDI87547.1 - 1.3 7.9 6.5 1.6 7.6 6.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Spt20 PF12090.8 CDI87547.1 - 1.7 8.2 38.8 2.5 7.7 38.8 1.2 1 0 0 1 1 1 0 Spt20 family MMU163 PF17119.5 CDI87547.1 - 2 7.5 8.7 3.5 6.7 8.7 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DUF3464 PF11947.8 CDI87547.1 - 2.2 8.0 12.7 5.9 6.6 12.7 1.7 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 CSG2 PF16965.5 CDI87547.1 - 2.7 6.8 4.5 3.4 6.5 4.5 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Connexin PF00029.19 CDI87547.1 - 3.5 7.3 9.3 5.6 6.6 9.3 1.3 1 0 0 1 1 1 0 Connexin Folate_carrier PF01770.18 CDI87547.1 - 5.8 5.5 8.8 9.8 4.8 8.8 1.4 1 0 0 1 1 1 0 Reduced folate carrier FAM60A PF15396.6 CDI87547.1 - 6.2 6.8 10.7 11 5.9 10.7 1.4 1 0 0 1 1 1 0 Protein Family FAM60A EIIBC-GUT_N PF03612.14 CDI87547.1 - 6.4 6.5 14.3 1.1 8.9 10.7 1.6 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus LIM_bind PF01803.16 CDI87547.1 - 6.5 6.2 16.4 12 5.3 16.4 1.4 1 0 0 1 1 1 0 LIM-domain binding protein Activator_LAG-3 PF11498.8 CDI87547.1 - 6.6 5.6 39.9 9.5 5.1 39.9 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DivIC PF04977.15 CDI87547.1 - 6.8 6.5 23.0 25 4.7 23.0 2.0 1 0 0 1 1 1 0 Septum formation initiator TRAP_alpha PF03896.16 CDI87548.1 - 0.026 13.7 1.0 0.031 13.5 1.0 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF3807 PF12720.7 CDI87548.1 - 0.053 13.8 19.4 0.058 13.7 19.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Connexin PF00029.19 CDI87548.1 - 0.066 13.0 16.5 0.071 12.9 16.5 1.0 1 0 0 1 1 1 0 Connexin DUF4834 PF16118.5 CDI87548.1 - 0.11 13.5 11.0 0.14 13.2 11.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) NPR3 PF03666.13 CDI87548.1 - 0.11 11.3 17.2 0.12 11.2 17.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CSG2 PF16965.5 CDI87548.1 - 0.12 11.3 6.8 0.13 11.2 6.8 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator RNA_pol_Rpc4 PF05132.14 CDI87548.1 - 0.12 12.8 13.2 0.12 12.8 13.2 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Afi1 PF07792.12 CDI87548.1 - 0.14 12.7 10.8 0.15 12.5 10.8 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Rtf2 PF04641.12 CDI87548.1 - 0.19 11.0 23.9 0.22 10.9 23.9 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger FAM176 PF14851.6 CDI87548.1 - 0.21 11.2 6.7 0.27 10.9 6.7 1.2 1 0 0 1 1 1 0 FAM176 family Scs3p PF10261.9 CDI87548.1 - 0.22 11.0 3.7 0.25 10.8 3.7 1.0 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM SID-1_RNA_chan PF13965.6 CDI87548.1 - 0.23 9.8 4.7 0.26 9.7 4.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CLN3 PF02487.17 CDI87548.1 - 0.23 10.5 7.6 0.25 10.4 7.6 1.0 1 0 0 1 1 1 0 CLN3 protein Gti1_Pac2 PF09729.9 CDI87548.1 - 0.26 11.3 13.5 0.29 11.2 13.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Presenilin PF01080.17 CDI87548.1 - 0.34 9.6 11.1 0.35 9.6 11.1 1.0 1 0 0 1 1 1 0 Presenilin RPN2_C PF18004.1 CDI87548.1 - 0.42 10.5 25.3 0.44 10.5 25.3 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain PRC2_HTH_1 PF18118.1 CDI87548.1 - 0.42 11.4 14.5 0.53 11.1 14.5 1.2 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain SpoIIP PF07454.11 CDI87548.1 - 0.43 10.0 14.5 0.43 10.0 14.5 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) OATP PF03137.20 CDI87548.1 - 0.45 8.7 11.1 0.48 8.7 11.1 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family IDO PF01231.18 CDI87548.1 - 0.46 9.2 9.1 0.52 9.0 9.1 1.1 1 0 0 1 1 1 0 Indoleamine 2,3-dioxygenase V_ATPase_I PF01496.19 CDI87548.1 - 0.55 8.1 15.8 0.62 7.9 15.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Kei1 PF08552.11 CDI87548.1 - 0.58 10.0 1.8 0.64 9.9 1.8 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Zip PF02535.22 CDI87548.1 - 0.6 9.3 6.7 0.65 9.1 6.7 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4175 PF13779.6 CDI87548.1 - 0.61 7.9 11.6 0.61 7.9 11.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF3464 PF11947.8 CDI87548.1 - 0.61 9.8 20.4 0.8 9.4 20.4 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 PPL5 PF18168.1 CDI87548.1 - 0.97 8.7 13.7 0.97 8.7 13.7 1.0 1 0 0 1 1 1 0 Prim-pol family 5 CBP_BcsG PF11658.8 CDI87548.1 - 1.1 7.6 5.7 1.1 7.5 5.7 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DUF2828 PF11443.8 CDI87548.1 - 1.2 7.1 19.4 1.1 7.2 19.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MMM1 PF10296.9 CDI87548.1 - 1.3 8.0 9.3 1.4 7.9 9.3 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 LicD PF04991.13 CDI87548.1 - 1.4 9.0 15.2 1.5 8.9 15.2 1.0 1 0 0 1 1 1 0 LicD family EIIBC-GUT_N PF03612.14 CDI87548.1 - 1.5 8.5 12.8 1.6 8.4 12.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Serinc PF03348.15 CDI87548.1 - 1.8 7.4 6.3 2 7.2 6.3 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4228 PF14009.6 CDI87548.1 - 2 8.8 12.3 2.2 8.7 12.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) ALMT PF11744.8 CDI87548.1 - 2.1 7.1 11.1 2.1 7.1 11.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter YMF19 PF02326.15 CDI87548.1 - 2.1 9.2 8.1 3.1 8.6 8.1 1.3 1 0 0 1 1 1 0 Plant ATP synthase F0 FHIPEP PF00771.20 CDI87548.1 - 2.2 6.6 6.9 2.4 6.5 6.9 1.1 1 0 0 1 1 1 0 FHIPEP family DDHD PF02862.17 CDI87548.1 - 2.5 8.2 10.2 2.5 8.2 10.2 1.1 1 0 0 1 1 1 0 DDHD domain CENP-N PF05238.13 CDI87548.1 - 2.6 7.3 15.7 2.7 7.2 15.7 1.0 1 0 0 1 1 1 0 Kinetochore protein CHL4 like Sec62 PF03839.16 CDI87548.1 - 2.6 7.5 21.8 3.9 6.9 21.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 PDCD2_C PF04194.13 CDI87548.1 - 2.7 8.0 12.9 3.2 7.8 12.9 1.1 1 0 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain Folate_carrier PF01770.18 CDI87548.1 - 2.8 6.6 8.7 2.8 6.6 8.7 1.0 1 0 0 1 1 1 0 Reduced folate carrier Paramyxo_ncap PF00973.19 CDI87548.1 - 3.1 6.6 10.7 3.3 6.5 10.7 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Otopetrin PF03189.13 CDI87548.1 - 3.2 6.5 6.6 3.4 6.4 6.6 1.0 1 0 0 1 1 1 0 Otopetrin Dpy19 PF10034.9 CDI87548.1 - 3.3 5.8 5.6 3.6 5.7 5.6 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation AAA_11 PF13086.6 CDI87548.1 - 3.4 7.4 17.3 3.4 7.4 17.3 1.0 1 0 0 1 1 1 0 AAA domain DUF2151 PF10221.9 CDI87548.1 - 3.4 6.1 15.6 3.5 6.1 15.6 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator DUF4569 PF15133.6 CDI87548.1 - 3.4 7.3 11.3 3.6 7.2 11.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Ctr PF04145.15 CDI87548.1 - 4.3 8.0 7.0 4.5 7.9 7.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family DUF913 PF06025.12 CDI87548.1 - 4.4 6.2 7.8 4.3 6.2 7.8 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF1764 PF08576.10 CDI87548.1 - 4.5 8.2 28.5 5.9 7.9 28.5 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) GNAT_acetyltr_2 PF13718.6 CDI87548.1 - 4.6 6.6 11.2 5.3 6.4 11.2 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 G0-G1_switch_2 PF15103.6 CDI87548.1 - 5.3 7.5 14.8 6.3 7.3 14.8 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 EOS1 PF12326.8 CDI87548.1 - 6.6 6.6 12.0 8 6.4 12.0 1.1 1 0 0 1 1 1 0 N-glycosylation protein Vfa1 PF08432.10 CDI87548.1 - 6.9 7.0 31.2 8.5 6.7 31.2 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Pex24p PF06398.11 CDI87548.1 - 7.4 5.4 11.3 8 5.3 11.3 1.0 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin AIF_C PF14721.6 CDI87548.1 - 7.4 6.9 12.9 9.1 6.6 12.9 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4770 PF15994.5 CDI87548.1 - 7.9 6.7 20.3 10 6.3 20.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) MAP17 PF15807.5 CDI87548.1 - 7.9 6.7 17.6 12 6.2 17.6 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Eapp_C PF10238.9 CDI87548.1 - 7.9 6.5 18.8 12 5.9 18.8 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein Peroxin-13_N PF04088.13 CDI87548.1 - 8.7 6.6 10.8 9.7 6.5 10.8 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region CNDH2_N PF06278.11 CDI87548.1 - 10 6.4 17.0 1.8e+02 2.3 17.0 2.0 1 1 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Utp14 PF04615.13 CDI87549.1 - 0.00051 18.8 13.0 0.00051 18.8 13.0 7.4 5 1 1 7 7 7 4 Utp14 protein TFIIF_alpha PF05793.12 CDI87550.1 - 0.0006 18.5 34.5 0.0006 18.5 34.5 2.1 2 0 0 2 2 2 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) ETRAMP PF09716.10 CDI87550.1 - 0.0096 16.0 9.6 0.0096 16.0 9.6 4.0 4 1 0 4 4 4 1 Malarial early transcribed membrane protein (ETRAMP) Utp14 PF04615.13 CDI87550.1 - 1 7.8 63.8 1.4 7.4 63.8 1.1 1 0 0 1 1 1 0 Utp14 protein SID-1_RNA_chan PF13965.6 CDI87551.1 - 0.0048 15.4 7.5 0.0053 15.2 7.5 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DUF2040 PF09745.9 CDI87551.1 - 0.016 15.2 24.0 0.02 14.9 24.0 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 55 (DUF2040) CBP_BcsG PF11658.8 CDI87551.1 - 0.03 12.7 14.1 0.033 12.6 14.1 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG PIP5K PF01504.18 CDI87551.1 - 0.032 13.5 13.3 0.038 13.2 13.3 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase NusG_II PF07009.11 CDI87551.1 - 0.033 14.4 6.9 0.066 13.4 6.9 1.6 1 1 0 1 1 1 0 NusG domain II V_ATPase_I PF01496.19 CDI87551.1 - 0.034 12.1 18.2 0.036 12.0 18.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2464 PF10240.9 CDI87551.1 - 0.06 12.9 10.6 0.065 12.8 10.6 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 O-antigen_lig PF13425.6 CDI87551.1 - 0.15 10.8 8.6 0.18 10.6 8.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CSG2 PF16965.5 CDI87551.1 - 0.16 10.9 9.8 0.21 10.5 9.8 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Serinc PF03348.15 CDI87551.1 - 0.16 10.8 11.6 0.22 10.4 11.6 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Neur_chan_memb PF02932.16 CDI87551.1 - 0.21 11.6 16.4 0.24 11.4 16.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 CDI87551.1 - 0.23 10.5 20.5 0.24 10.4 20.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Paf1 PF03985.13 CDI87551.1 - 0.24 10.3 23.5 0.26 10.2 23.5 1.0 1 0 0 1 1 1 0 Paf1 MENTAL PF10457.9 CDI87551.1 - 0.35 10.6 6.2 0.45 10.3 6.2 1.1 1 0 0 1 1 1 0 Cholesterol-capturing domain Velvet PF11754.8 CDI87551.1 - 0.41 10.5 19.4 0.47 10.4 19.4 1.0 1 0 0 1 1 1 0 Velvet factor Band_3_cyto PF07565.13 CDI87551.1 - 0.55 10.0 22.1 0.64 9.8 22.1 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4484 PF14831.6 CDI87551.1 - 0.58 10.2 16.7 0.68 9.9 16.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) DUF4746 PF15928.5 CDI87551.1 - 0.61 9.5 15.9 0.68 9.3 15.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CobT PF06213.12 CDI87551.1 - 0.62 9.4 31.5 0.71 9.2 31.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Rtf2 PF04641.12 CDI87551.1 - 0.69 9.2 17.6 0.75 9.1 17.6 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger CDC45 PF02724.14 CDI87551.1 - 0.77 8.0 19.3 0.85 7.8 19.3 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 CDI87551.1 - 0.95 8.4 16.8 1.1 8.2 16.8 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2828 PF11443.8 CDI87551.1 - 1.1 7.2 20.2 1.2 7.1 20.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF1980 PF09323.10 CDI87551.1 - 1.5 8.7 20.7 2.5 8.0 20.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) PIEZO PF15917.5 CDI87551.1 - 1.5 8.3 27.9 1.8 8.0 27.9 1.2 1 0 0 1 1 1 0 Piezo Baculo_PP31 PF05311.11 CDI87551.1 - 1.6 8.2 18.5 1.9 7.9 18.5 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) CPSF100_C PF13299.6 CDI87551.1 - 1.9 8.6 19.4 2.2 8.4 19.4 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Hid1 PF12722.7 CDI87551.1 - 2.3 6.3 20.1 2.5 6.1 20.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MDM10 PF12519.8 CDI87551.1 - 2.4 6.9 21.0 2.7 6.8 21.0 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 MMU163 PF17119.5 CDI87551.1 - 2.5 7.2 11.1 3.2 6.8 11.1 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Folliculin PF11704.8 CDI87551.1 - 2.7 7.9 16.9 3.3 7.6 16.9 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Proton_antipo_C PF01010.19 CDI87551.1 - 2.9 7.5 8.4 3.6 7.2 8.4 1.1 1 0 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus Membralin PF09746.9 CDI87551.1 - 3.5 6.6 15.2 3.8 6.5 15.2 1.2 1 0 0 1 1 1 0 Tumour-associated protein VIR_N PF15912.5 CDI87551.1 - 4.4 6.8 15.6 5.2 6.6 15.6 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DDHD PF02862.17 CDI87551.1 - 5 7.2 22.0 6 7.0 22.0 1.1 1 0 0 1 1 1 0 DDHD domain HCO3_cotransp PF00955.21 CDI87551.1 - 5.3 5.8 9.9 5.5 5.7 9.9 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF4471 PF14740.6 CDI87551.1 - 5.9 6.0 21.5 7.3 5.7 21.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) RR_TM4-6 PF06459.12 CDI87551.1 - 6.7 6.5 23.9 7.5 6.3 23.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NEMP PF10225.9 CDI87551.1 - 7.1 6.2 9.5 10 5.7 9.5 1.3 1 0 0 1 1 1 0 NEMP family Pex14_N PF04695.13 CDI87551.1 - 8.6 7.0 34.8 12 6.5 34.8 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Mem_trans PF03547.18 CDI87551.1 - 9.4 4.5 8.8 12 4.2 8.8 1.2 1 0 0 1 1 1 0 Membrane transport protein ALMT PF11744.8 CDI87551.1 - 9.5 4.9 17.7 10 4.9 17.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Ctr PF04145.15 CDI87551.1 - 9.6 6.8 16.6 16 6.1 16.6 1.4 1 1 0 1 1 1 0 Ctr copper transporter family SpoIIP PF07454.11 CDI87551.1 - 9.8 5.5 25.6 12 5.3 25.6 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SUIM_assoc PF16619.5 CDI87552.1 - 0.017 15.1 16.3 0.017 15.1 16.3 4.7 6 1 0 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 Rubella_E2 PF05749.11 CDI87552.1 - 0.048 13.1 0.7 0.084 12.3 0.7 1.4 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 SDA1 PF05285.12 CDI87553.1 - 0.13 11.7 58.4 0.2 11.1 58.4 1.2 1 0 0 1 1 1 0 SDA1 Paf1 PF03985.13 CDI87554.1 - 0.014 14.4 6.0 0.017 14.2 6.0 1.1 1 0 0 1 1 1 0 Paf1 THOC2_N PF16134.5 CDI87554.1 - 0.018 13.7 1.0 0.021 13.5 1.0 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus FAM176 PF14851.6 CDI87554.1 - 0.037 13.7 4.7 0.065 12.9 4.7 1.3 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 CDI87554.1 - 0.064 12.6 2.6 0.079 12.3 2.6 1.1 1 0 0 1 1 1 0 NOA36 protein SCF PF02404.15 CDI87554.1 - 0.21 10.9 0.5 0.27 10.5 0.5 1.1 1 0 0 1 1 1 0 Stem cell factor Presenilin PF01080.17 CDI87554.1 - 0.29 9.9 1.6 0.36 9.5 1.6 1.2 1 0 0 1 1 1 0 Presenilin OAD_gamma PF04277.13 CDI87554.1 - 0.31 11.6 13.6 0.74 10.4 0.6 3.0 2 1 1 3 3 3 0 Oxaloacetate decarboxylase, gamma chain PEX11 PF05648.14 CDI87554.1 - 1.3 8.4 4.0 1.6 8.1 3.3 1.6 1 1 1 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) Myc_N PF01056.18 CDI87554.1 - 2 8.2 7.9 0.49 10.2 4.4 1.7 2 0 0 2 2 2 0 Myc amino-terminal region RskA PF10099.9 CDI87555.1 - 0.0033 17.8 48.0 0.024 14.9 14.2 3.1 1 1 2 3 3 3 3 Anti-sigma-K factor rskA O-antigen_lig PF13425.6 CDI87555.1 - 0.076 11.8 5.0 0.089 11.6 5.0 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SUA5 PF03481.13 CDI87555.1 - 0.12 13.0 29.6 5.7 7.5 29.6 2.6 1 1 0 1 1 1 0 Putative GTP-binding controlling metal-binding Hamartin PF04388.12 CDI87555.1 - 1 7.9 36.1 1.3 7.6 36.1 1.1 1 0 0 1 1 1 0 Hamartin protein DUF4764 PF15961.5 CDI87555.1 - 6.9 5.2 39.4 8.6 4.9 39.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4764) RskA PF10099.9 CDI87556.1 - 1.5e-05 25.4 45.6 0.0005 20.4 21.0 6.8 5 1 2 7 7 7 3 Anti-sigma-K factor rskA Dynactin_p62 PF05502.13 CDI87556.1 - 2e-05 23.6 16.5 2e-05 23.6 16.5 4.2 4 1 0 4 4 4 2 Dynactin p62 family DUF2722 PF10846.8 CDI87556.1 - 8.6e-05 21.7 47.9 0.0053 15.8 17.9 4.0 4 0 0 4 4 4 3 Protein of unknown function (DUF2722) PRCC PF10253.9 CDI87556.1 - 0.00055 20.8 2.1 0.00055 20.8 2.1 4.8 3 1 0 4 4 4 1 Mitotic checkpoint regulator, MAD2B-interacting OATP PF03137.20 CDI87556.1 - 0.41 8.9 4.1 0.35 9.1 1.4 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Peptidase_S49_N PF08496.10 CDI87556.1 - 0.46 10.5 16.5 5.3 7.1 4.0 4.2 4 0 0 4 4 4 0 Peptidase family S49 N-terminal eIF-3_zeta PF05091.12 CDI87556.1 - 6.1 5.7 24.2 3.9 6.3 9.0 3.3 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_M48_N PF16491.5 CDI87558.1 - 6.9e-54 182.5 0.6 1.9e-53 181.1 0.1 1.9 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 CDI87558.1 - 2.2e-32 112.4 0.1 5.7e-32 111.1 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M48 SASP_gamma PF04259.14 CDI87559.1 - 7.5e-06 26.4 2.1 0.072 13.6 0.3 2.1 2 0 0 2 2 2 2 Small, acid-soluble spore protein, gamma-type Metallophos_C PF14008.6 CDI87559.1 - 0.061 14.2 0.6 12 6.9 0.1 2.2 1 1 1 2 2 2 0 Iron/zinc purple acid phosphatase-like protein C Str_synth PF03088.16 CDI87560.1 - 0.16 12.1 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 Strictosidine synthase RskA PF10099.9 CDI87561.1 - 0.00027 21.3 10.2 0.00027 21.3 10.2 4.6 1 1 2 4 4 4 1 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI87561.1 - 0.64 8.9 18.8 1.1 8.1 18.8 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF572 PF04502.13 CDI87562.1 - 0.48 10.0 49.3 0.6 9.7 49.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Utp14 PF04615.13 CDI87562.1 - 4 5.9 53.0 4.7 5.7 53.0 1.0 1 0 0 1 1 1 0 Utp14 protein SR-25 PF10500.9 CDI87562.1 - 4.2 6.9 56.0 1.3 8.6 23.2 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein LAP1C PF05609.12 CDI87562.1 - 8.6 5.3 51.7 12 4.9 51.7 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RNA_replicase_B PF03431.13 CDI87563.1 - 0.42 9.0 6.2 0.47 8.8 6.2 1.0 1 0 0 1 1 1 0 RNA replicase, beta-chain NPR3 PF03666.13 CDI87563.1 - 0.43 9.3 24.6 0.44 9.3 24.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PPP4R2 PF09184.11 CDI87563.1 - 0.68 9.5 23.4 0.71 9.4 23.4 1.0 1 0 0 1 1 1 0 PPP4R2 HEAT_EZ PF13513.6 CDI87563.1 - 0.82 10.3 0.1 0.82 10.3 0.1 2.9 2 1 0 2 2 1 0 HEAT-like repeat Presenilin PF01080.17 CDI87563.1 - 1.8 7.2 33.0 2 7.1 33.0 1.1 1 0 0 1 1 1 0 Presenilin NARP1 PF12569.8 CDI87563.1 - 2.1 7.1 25.9 2.4 7.0 25.9 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 V_ATPase_I PF01496.19 CDI87563.1 - 2.8 5.7 27.1 2.7 5.8 27.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 CDI87563.1 - 2.9 7.6 32.2 3.2 7.5 32.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2828 PF11443.8 CDI87563.1 - 3.3 5.7 25.2 3.2 5.7 25.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4746 PF15928.5 CDI87563.1 - 3.6 6.9 20.8 3.7 6.9 20.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MCM_bind PF09739.9 CDI87563.1 - 3.7 5.9 26.3 3.7 5.9 26.3 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Velvet PF11754.8 CDI87563.1 - 5.6 6.8 25.4 6.4 6.6 25.4 1.1 1 0 0 1 1 1 0 Velvet factor Pannexin_like PF12534.8 CDI87563.1 - 6 5.9 18.1 6 5.8 18.1 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF913 PF06025.12 CDI87563.1 - 6.5 5.6 19.3 6.8 5.6 19.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DDHD PF02862.17 CDI87563.1 - 6.8 6.8 26.1 9.8 6.3 26.1 1.3 1 0 0 1 1 1 0 DDHD domain SID-1_RNA_chan PF13965.6 CDI87563.1 - 7.1 4.9 13.8 6.7 5.0 13.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 eIF-3_zeta PF05091.12 CDI87563.1 - 7.3 5.4 35.9 7.5 5.4 35.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CLN3 PF02487.17 CDI87563.1 - 8 5.4 19.9 7.5 5.5 19.9 1.2 1 0 0 1 1 1 0 CLN3 protein SelP_N PF04592.14 CDI87563.1 - 8 5.8 26.3 10 5.4 26.3 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF2620 PF10941.8 CDI87564.1 - 0.027 14.6 0.9 0.53 10.4 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF2620 AF-4 PF05110.13 CDI87564.1 - 0.064 11.3 22.6 0.076 11.1 22.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Apt1 PF10351.9 CDI87564.1 - 0.13 11.0 5.4 0.14 11.0 5.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain PIP5K PF01504.18 CDI87565.1 - 0.026 13.7 6.7 0.029 13.6 6.7 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase NPR3 PF03666.13 CDI87565.1 - 0.24 10.2 11.4 0.24 10.1 11.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Afi1 PF07792.12 CDI87565.1 - 0.38 11.3 14.0 0.46 11.0 14.0 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Connexin PF00029.19 CDI87565.1 - 0.58 9.9 11.2 0.63 9.8 11.2 1.1 1 0 0 1 1 1 0 Connexin DUF4366 PF14283.6 CDI87565.1 - 0.7 9.9 13.9 0.98 9.5 13.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Kei1 PF08552.11 CDI87565.1 - 1 9.2 5.0 1.2 9.0 5.0 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 TRAP_alpha PF03896.16 CDI87565.1 - 1.3 8.2 15.5 1.6 7.8 15.5 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CSRNP_N PF16019.5 CDI87565.1 - 1.4 8.8 12.8 1.5 8.7 12.8 1.0 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus FAM60A PF15396.6 CDI87565.1 - 1.4 8.8 8.7 1.4 8.9 8.7 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF913 PF06025.12 CDI87565.1 - 1.5 7.8 11.1 1.5 7.7 11.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CSG2 PF16965.5 CDI87565.1 - 1.8 7.4 5.7 1.9 7.3 5.7 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator NESP55 PF06390.12 CDI87565.1 - 1.9 8.0 30.8 2.8 7.5 30.8 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Tim54 PF11711.8 CDI87565.1 - 2.2 7.0 17.1 2.5 6.8 17.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DNA_pol_phi PF04931.13 CDI87565.1 - 2.6 6.0 23.7 2.5 6.1 23.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi Zip PF02535.22 CDI87565.1 - 2.6 7.2 11.4 2.9 7.0 11.4 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter HCO3_cotransp PF00955.21 CDI87565.1 - 3.2 6.4 4.4 3.3 6.4 4.4 1.0 1 0 0 1 1 1 0 HCO3- transporter family RP-C_C PF11800.8 CDI87565.1 - 3.5 7.7 12.2 3.6 7.6 12.2 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region DDHD PF02862.17 CDI87565.1 - 3.7 7.7 7.9 4.6 7.3 7.9 1.2 1 0 0 1 1 1 0 DDHD domain DUF2828 PF11443.8 CDI87565.1 - 3.7 5.5 12.1 4 5.4 12.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SID-1_RNA_chan PF13965.6 CDI87565.1 - 4.4 5.6 8.9 4.6 5.5 8.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI87565.1 - 4.6 6.1 8.7 5 5.9 8.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) SpoIIP PF07454.11 CDI87565.1 - 8.7 5.7 17.4 10 5.4 17.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Sec62 PF03839.16 CDI87565.1 - 9.8 5.6 14.0 11 5.5 14.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 CLN3 PF02487.17 CDI87565.1 - 9.9 5.1 9.6 11 4.9 9.6 1.0 1 0 0 1 1 1 0 CLN3 protein DUF2722 PF10846.8 CDI87566.1 - 3.8e-07 29.4 38.4 2e-05 23.8 8.3 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI87566.1 - 5.6e-06 26.1 53.1 0.0029 17.3 23.6 2.3 2 0 0 2 2 2 2 Spt20 family RskA PF10099.9 CDI87566.1 - 0.00015 22.1 5.5 0.00015 22.1 5.5 3.8 2 2 1 3 3 1 1 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI87566.1 - 0.00046 19.3 21.4 0.021 13.8 1.3 2.1 2 0 0 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EPL1 PF10513.9 CDI87566.1 - 0.00061 20.2 15.9 0.17 12.2 0.6 2.4 2 0 0 2 2 2 2 Enhancer of polycomb-like Ribosomal_60s PF00428.19 CDI87566.1 - 0.00088 19.8 5.7 0.00088 19.8 5.7 4.6 3 1 0 3 3 2 1 60s Acidic ribosomal protein DUF4471 PF14740.6 CDI87566.1 - 0.0017 17.6 8.7 0.016 14.5 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4471) Suf PF05843.14 CDI87566.1 - 0.0081 16.2 25.5 0.23 11.4 6.9 2.4 2 0 0 2 2 2 2 Suppressor of forked protein (Suf) Thg1C PF14413.6 CDI87566.1 - 0.0086 16.2 10.7 0.18 12.0 0.3 2.4 2 0 0 2 2 2 1 Thg1 C terminal domain MCM_bind PF09739.9 CDI87566.1 - 0.013 14.0 15.8 0.017 13.6 1.7 2.2 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor EOS1 PF12326.8 CDI87566.1 - 0.016 15.1 4.2 1.3 8.9 0.8 2.2 2 0 0 2 2 2 0 N-glycosylation protein Connexin PF00029.19 CDI87566.1 - 0.019 14.7 9.9 0.44 10.3 4.3 2.2 2 0 0 2 2 2 0 Connexin AAA_23 PF13476.6 CDI87566.1 - 0.02 15.4 20.4 0.33 11.4 8.3 2.2 2 0 0 2 2 2 0 AAA domain Rxt3 PF08642.10 CDI87566.1 - 0.024 15.4 6.1 3.3 8.5 2.2 2.5 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 DUF4518 PF15008.6 CDI87566.1 - 0.028 13.6 15.6 0.23 10.6 3.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) DUF3807 PF12720.7 CDI87566.1 - 0.033 14.5 22.1 0.38 11.0 2.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) DUF5523 PF17661.1 CDI87566.1 - 0.034 13.8 14.8 0.57 9.8 5.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) FHIPEP PF00771.20 CDI87566.1 - 0.039 12.4 12.7 0.076 11.5 0.9 2.3 2 0 0 2 2 2 0 FHIPEP family TFIIA PF03153.13 CDI87566.1 - 0.041 13.9 68.6 0.043 13.8 23.3 2.1 1 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4207 PF13904.6 CDI87566.1 - 0.052 13.2 42.0 0.05 13.3 12.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) RAB3GAP2_N PF14655.6 CDI87566.1 - 0.06 12.6 18.2 0.065 12.5 4.8 2.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Pkinase_fungal PF17667.1 CDI87566.1 - 0.063 12.0 6.2 1.1 7.9 0.1 2.1 2 0 0 2 2 2 0 Fungal protein kinase DUF4820 PF16091.5 CDI87566.1 - 0.064 12.6 13.2 0.7 9.2 5.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) EIF4E-T PF10477.9 CDI87566.1 - 0.071 11.9 21.9 0.29 9.9 4.9 2.0 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E FAM176 PF14851.6 CDI87566.1 - 0.074 12.7 7.7 1.6 8.3 3.0 2.4 2 0 0 2 2 2 0 FAM176 family FAM60A PF15396.6 CDI87566.1 - 0.076 13.0 9.8 2.1 8.3 0.2 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Peptidase_S49_N PF08496.10 CDI87566.1 - 0.09 12.8 16.5 0.49 10.4 6.5 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal ART-PolyVal PF18760.1 CDI87566.1 - 0.095 13.7 9.2 1.1 10.3 3.7 2.3 2 0 0 2 2 2 0 ADP-Ribosyltransferase in polyvalent proteins TERB2 PF15101.6 CDI87566.1 - 0.13 12.3 28.8 0.68 10.0 6.7 2.4 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Serinc PF03348.15 CDI87566.1 - 0.14 11.1 5.4 1.6 7.5 1.4 2.3 2 0 0 2 2 2 0 Serine incorporator (Serinc) ATAD4 PF15321.6 CDI87566.1 - 0.15 13.4 11.0 2.2 9.7 3.0 2.7 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 DUF3408 PF11888.8 CDI87566.1 - 0.18 11.9 18.1 0.51 10.5 6.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) SpoIIP PF07454.11 CDI87566.1 - 0.19 11.2 19.3 1.1 8.7 7.4 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) OATP PF03137.20 CDI87566.1 - 0.23 9.7 8.3 1 7.6 0.1 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family RICTOR_N PF14664.6 CDI87566.1 - 0.27 10.2 4.9 2.7 6.9 0.1 2.2 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term TFB6 PF17110.5 CDI87566.1 - 0.27 10.9 8.0 6.3 6.5 4.0 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Dala_Dala_lig_N PF01820.21 CDI87566.1 - 0.28 11.7 2.6 8.7 6.9 0.1 2.4 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus RMP PF14996.6 CDI87566.1 - 0.29 11.3 18.0 1.6 8.9 3.8 2.3 2 0 0 2 2 2 0 Retinal Maintenance DUF1115 PF06544.12 CDI87566.1 - 0.34 11.0 11.0 1.7 8.8 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1115) PRP1_N PF06424.12 CDI87566.1 - 0.39 11.1 15.8 1.5 9.2 5.1 2.4 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Afi1 PF07792.12 CDI87566.1 - 0.41 11.1 12.7 3.5 8.1 4.3 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MPM1 PF17234.2 CDI87566.1 - 0.41 10.9 22.8 0.92 9.7 5.6 2.3 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF4746 PF15928.5 CDI87566.1 - 0.44 9.9 11.2 1.1 8.7 3.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) CRF1 PF10380.9 CDI87566.1 - 0.44 10.9 7.1 3.2 8.1 0.3 2.5 2 0 0 2 2 2 0 Transcription factor CRF1 DUF2072 PF09845.9 CDI87566.1 - 0.46 10.8 8.6 5.5 7.3 3.0 2.5 2 0 0 2 2 2 0 Zn-ribbon containing protein Maf1 PF09174.10 CDI87566.1 - 0.46 10.6 7.7 4.1 7.5 0.2 2.3 2 0 0 2 2 2 0 Maf1 regulator DUF4770 PF15994.5 CDI87566.1 - 0.5 10.6 21.8 0.23 11.7 3.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) DUF1644 PF07800.12 CDI87566.1 - 0.62 10.1 9.3 3.5 7.7 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) INSIG PF07281.12 CDI87566.1 - 0.63 9.6 4.3 4.7 6.8 0.2 2.5 2 0 0 2 2 2 0 Insulin-induced protein (INSIG) DUF4011 PF13195.6 CDI87566.1 - 0.66 9.9 5.9 5.3 6.9 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4011) Baculo_PP31 PF05311.11 CDI87566.1 - 0.66 9.4 11.9 2.3 7.6 0.8 2.2 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) PRC2_HTH_1 PF18118.1 CDI87566.1 - 0.67 10.8 11.5 3.2 8.6 3.1 2.7 3 0 0 3 3 2 0 Polycomb repressive complex 2 tri-helical domain DUF3299 PF11736.8 CDI87566.1 - 0.72 9.9 9.9 3.2 7.7 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3299) PSK PF06404.12 CDI87566.1 - 0.78 10.8 22.2 1.1 10.3 1.7 3.0 3 0 0 3 3 2 0 Phytosulfokine precursor protein (PSK) DUF1980 PF09323.10 CDI87566.1 - 0.89 9.4 9.6 5.4 6.9 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Tsg PF04668.12 CDI87566.1 - 0.9 10.2 11.2 2.2 9.0 1.1 2.4 2 0 0 2 2 2 0 Twisted gastrulation (Tsg) protein conserved region TRM13 PF05206.14 CDI87566.1 - 1 8.8 12.1 1.6 8.2 0.8 2.2 2 0 0 2 2 2 0 Methyltransferase TRM13 Gaa1 PF04114.14 CDI87566.1 - 1.1 8.3 8.5 0.29 10.1 0.3 2.1 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component ALMT PF11744.8 CDI87566.1 - 1.3 7.7 11.2 3.8 6.2 0.2 2.2 2 0 0 2 2 2 0 Aluminium activated malate transporter CLN3 PF02487.17 CDI87566.1 - 1.4 7.9 11.9 3.3 6.7 0.4 2.2 2 0 0 2 2 2 0 CLN3 protein Stig1 PF04885.13 CDI87566.1 - 1.4 9.4 10.6 9.5 6.7 3.7 2.5 2 0 0 2 2 2 0 Stigma-specific protein, Stig1 MMR1 PF08505.10 CDI87566.1 - 1.4 9.1 29.9 0.59 10.4 13.6 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein PH_4 PF15404.6 CDI87566.1 - 1.7 8.4 11.6 3.9 7.2 1.1 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain Rtf2 PF04641.12 CDI87566.1 - 1.8 7.9 14.8 2.9 7.2 0.4 2.4 2 0 0 2 2 2 0 Rtf2 RING-finger BRF1 PF07741.13 CDI87566.1 - 1.8 8.9 23.5 0.91 9.9 1.0 2.7 2 1 0 2 2 2 0 Brf1-like TBP-binding domain LIM_bind PF01803.16 CDI87566.1 - 2.1 7.8 16.0 1.6 8.2 1.4 2.3 2 0 0 2 2 2 0 LIM-domain binding protein Sec62 PF03839.16 CDI87566.1 - 2.3 7.7 13.4 5 6.6 5.1 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 FixO PF02433.15 CDI87566.1 - 2.4 7.5 9.9 5.1 6.5 0.3 2.4 2 0 0 2 2 2 0 Cytochrome C oxidase, mono-heme subunit/FixO MecA PF05389.12 CDI87566.1 - 2.5 7.7 23.4 0.11 12.1 1.8 2.3 1 1 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF3371 PF11851.8 CDI87566.1 - 2.6 9.2 25.5 7.2 7.7 9.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) Peptidase_U57 PF05582.12 CDI87566.1 - 2.8 7.1 9.1 7.1 5.8 0.3 2.2 2 0 0 2 2 2 0 YabG peptidase U57 Agouti PF05039.12 CDI87566.1 - 3 8.6 14.6 8.5 7.2 4.1 2.9 2 0 0 2 2 2 0 Agouti protein Paf1 PF03985.13 CDI87566.1 - 3.3 6.6 21.5 0.89 8.5 7.4 2.3 2 0 0 2 2 2 0 Paf1 DNA_pol3_alpha PF07733.12 CDI87566.1 - 3.9 7.0 12.5 0.42 10.1 5.9 2.2 2 0 0 2 2 2 0 Bacterial DNA polymerase III alpha NTPase domain VIR_N PF15912.5 CDI87566.1 - 4 7.0 9.7 13 5.3 5.5 2.1 2 0 0 2 2 2 0 Virilizer, N-terminal UPF0239 PF06783.11 CDI87566.1 - 4.6 7.5 10.4 18 5.6 0.4 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) DUF1645 PF07816.11 CDI87566.1 - 5.1 7.6 13.9 41 4.7 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1645) MTP18 PF10558.9 CDI87566.1 - 5.2 7.0 8.8 5 7.1 0.2 2.3 2 0 0 2 2 2 0 Mitochondrial 18 KDa protein (MTP18) DUF2347 PF09804.9 CDI87566.1 - 5.8 6.4 9.9 12 5.4 3.4 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2347) RR_TM4-6 PF06459.12 CDI87566.1 - 6.5 6.5 21.0 5.5 6.7 9.2 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 CDI87566.1 - 6.9 4.7 16.3 2 6.5 7.3 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein UPF0524 PF15823.5 CDI87566.1 - 7.2 5.9 14.6 1 8.7 1.8 2.3 2 0 0 2 2 2 0 UPF0524 of C3orf70 MDM31_MDM32 PF08118.11 CDI87566.1 - 7.6 5.1 12.3 5.8 5.5 0.2 2.2 2 0 0 2 2 2 0 Yeast mitochondrial distribution and morphology (MDM) proteins SUFU_C PF12470.8 CDI87566.1 - 8.1 6.4 13.6 8.2 6.4 1.5 2.3 2 0 0 2 2 2 0 Suppressor of Fused Gli/Ci N terminal binding domain RskA PF10099.9 CDI87567.1 - 0.006 16.9 23.6 0.0077 16.5 23.6 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF3450 PF11932.8 CDI87567.1 - 0.093 12.0 27.3 0.11 11.8 27.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Tetraspanin PF00335.20 CDI87567.1 - 0.18 11.5 1.0 0.18 11.5 1.0 1.2 1 0 0 1 1 1 0 Tetraspanin family Suf PF05843.14 CDI87567.1 - 0.19 11.7 10.6 0.19 11.7 10.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) IATP PF04568.12 CDI87567.1 - 0.21 12.0 12.9 0.26 11.7 12.9 1.2 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP IHABP4_N PF16174.5 CDI87567.1 - 0.27 11.8 16.5 0.33 11.5 16.5 1.1 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal MMR1 PF08505.10 CDI87567.1 - 0.35 11.1 10.7 0.34 11.1 10.7 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein VIT1 PF01988.19 CDI87567.1 - 0.35 10.7 9.6 0.42 10.4 9.6 1.1 1 0 0 1 1 1 0 VIT family Bud13 PF09736.9 CDI87567.1 - 0.42 11.0 11.7 0.48 10.8 11.7 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex YjeF_N PF03853.15 CDI87567.1 - 0.45 10.4 8.5 0.51 10.2 8.5 1.1 1 0 0 1 1 1 0 YjeF-related protein N-terminus DUF2034 PF10356.9 CDI87567.1 - 0.48 9.8 7.6 0.63 9.4 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2034) AAA_23 PF13476.6 CDI87567.1 - 0.7 10.4 12.6 0.75 10.3 12.6 1.1 1 0 0 1 1 1 0 AAA domain PMSI1 PF15322.6 CDI87567.1 - 1 8.7 8.9 1.2 8.5 8.9 1.1 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative PBP_sp32 PF07222.12 CDI87567.1 - 1 8.7 10.7 1.1 8.7 10.7 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Band_3_cyto PF07565.13 CDI87567.1 - 1.1 9.0 10.2 1.3 8.7 10.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Neur_chan_memb PF02932.16 CDI87567.1 - 1.1 9.2 5.0 1 9.3 5.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_S15 PF02129.18 CDI87567.1 - 1.2 8.7 11.0 1.5 8.4 11.0 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) CLN3 PF02487.17 CDI87567.1 - 1.6 7.7 9.0 2.1 7.3 9.0 1.1 1 0 0 1 1 1 0 CLN3 protein LMBR1 PF04791.16 CDI87567.1 - 1.7 7.5 4.7 1.6 7.6 4.7 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1980 PF09323.10 CDI87567.1 - 1.7 8.5 7.6 1.9 8.4 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) SprA-related PF12118.8 CDI87567.1 - 1.9 7.5 28.0 2.2 7.3 28.0 1.0 1 0 0 1 1 1 0 SprA-related family R_equi_Vir PF05526.11 CDI87567.1 - 2.1 8.2 9.7 2.8 7.8 9.7 1.3 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Presenilin PF01080.17 CDI87567.1 - 2.1 7.0 11.8 2.2 6.9 11.8 1.0 1 0 0 1 1 1 0 Presenilin Med15 PF09606.10 CDI87567.1 - 2.4 6.7 34.0 2.5 6.7 34.0 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Gastrin PF00918.17 CDI87567.1 - 2.6 9.0 10.9 3.2 8.7 10.9 1.1 1 0 0 1 1 1 0 Gastrin/cholecystokinin family TFIIA PF03153.13 CDI87567.1 - 2.6 7.9 33.9 2.8 7.8 33.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit HemX PF04375.14 CDI87567.1 - 2.8 7.1 31.9 3.2 7.0 31.9 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase FAM199X PF15814.5 CDI87567.1 - 2.9 6.9 9.5 3.4 6.6 9.5 1.1 1 0 0 1 1 1 0 Protein family FAM199X DDHD PF02862.17 CDI87567.1 - 2.9 8.0 10.1 3 7.9 10.1 1.1 1 0 0 1 1 1 0 DDHD domain OATP PF03137.20 CDI87567.1 - 4.7 5.4 5.8 5.4 5.2 5.8 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Spt20 PF12090.8 CDI87567.1 - 5.1 6.6 33.9 7.1 6.2 33.9 1.2 1 0 0 1 1 1 0 Spt20 family Serinc PF03348.15 CDI87567.1 - 6.2 5.6 6.2 5.9 5.7 6.2 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Roughex PF06020.11 CDI87567.1 - 9 5.3 12.4 11 5.0 12.4 1.2 1 0 0 1 1 1 0 Drosophila roughex protein AF-4 PF05110.13 CDI87568.1 - 0.00046 18.5 20.5 0.00046 18.5 20.5 10.8 9 2 4 13 13 13 3 AF-4 proto-oncoprotein RskA PF10099.9 CDI87568.1 - 0.0028 18.0 7.2 0.0028 18.0 7.2 25.0 7 5 10 21 21 21 3 Anti-sigma-K factor rskA FYRN PF05964.14 CDI87568.1 - 0.03 14.2 0.0 0.097 12.5 0.0 1.9 1 0 0 1 1 1 0 F/Y-rich N-terminus TFIIA PF03153.13 CDI87569.1 - 1.8 8.5 56.8 2.5 8.0 56.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IMS PF00817.20 CDI87572.1 - 2.9e-30 105.2 0.0 4.7e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family TFIIA PF03153.13 CDI87572.1 - 0.0025 17.9 27.2 0.0037 17.3 27.2 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI87572.1 - 0.015 15.5 3.1 0.023 14.8 3.1 1.2 1 0 0 1 1 1 0 DDHD domain Spt20 PF12090.8 CDI87572.1 - 0.061 12.9 38.2 0.093 12.3 38.2 1.1 1 0 0 1 1 1 0 Spt20 family DUF4746 PF15928.5 CDI87572.1 - 0.24 10.8 3.2 0.36 10.2 3.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SpoIIP PF07454.11 CDI87572.1 - 0.31 10.4 10.3 0.54 9.7 10.3 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Band_3_cyto PF07565.13 CDI87572.1 - 0.45 10.3 7.6 0.67 9.7 7.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4834 PF16118.5 CDI87572.1 - 0.51 11.3 12.7 0.93 10.5 12.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) BORG_CEP PF14957.6 CDI87572.1 - 0.54 11.4 5.3 1.3 10.2 5.3 1.6 1 0 0 1 1 1 0 Cdc42 effector MecA PF05389.12 CDI87572.1 - 0.59 9.7 6.0 0.97 9.0 6.0 1.2 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF4175 PF13779.6 CDI87572.1 - 0.66 7.8 23.7 0.97 7.3 23.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Neur_chan_memb PF02932.16 CDI87572.1 - 1 9.4 6.7 1.7 8.7 6.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Otopetrin PF03189.13 CDI87572.1 - 1.1 7.9 5.2 1.5 7.5 5.2 1.1 1 0 0 1 1 1 0 Otopetrin DUF4770 PF15994.5 CDI87572.1 - 1.1 9.4 14.3 1.9 8.7 14.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Asparaginase_2 PF01112.18 CDI87572.1 - 1.4 7.8 5.5 2 7.3 5.5 1.1 1 0 0 1 1 1 0 Asparaginase EPL1 PF10513.9 CDI87572.1 - 1.4 9.2 12.3 2.3 8.6 11.9 1.5 2 0 0 2 2 1 0 Enhancer of polycomb-like RR_TM4-6 PF06459.12 CDI87572.1 - 1.5 8.6 10.4 2.3 8.0 10.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_S64 PF08192.11 CDI87572.1 - 1.9 6.9 8.7 2.6 6.4 8.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 PSK PF06404.12 CDI87572.1 - 2.1 9.4 13.0 3.9 8.5 13.0 1.4 1 0 0 1 1 1 0 Phytosulfokine precursor protein (PSK) PAT1 PF09770.9 CDI87572.1 - 2.6 6.2 21.9 3.4 5.8 21.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4820 PF16091.5 CDI87572.1 - 2.7 7.3 9.8 3.8 6.8 9.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Eapp_C PF10238.9 CDI87572.1 - 2.7 8.1 15.7 4.9 7.2 15.7 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein SLC12 PF03522.15 CDI87572.1 - 3.5 6.6 10.5 4.9 6.1 10.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4718 PF15842.5 CDI87572.1 - 3.6 7.4 5.1 5.6 6.7 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) DUF913 PF06025.12 CDI87572.1 - 4.8 6.0 9.6 7.4 5.4 9.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Sec62 PF03839.16 CDI87572.1 - 4.9 6.6 7.8 7.3 6.0 7.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 MCU PF04678.13 CDI87572.1 - 5 7.2 7.4 7.5 6.6 7.4 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter EOS1 PF12326.8 CDI87572.1 - 6.2 6.7 4.6 9.4 6.1 4.6 1.2 1 0 0 1 1 1 0 N-glycosylation protein CobT PF06213.12 CDI87572.1 - 6.7 6.0 19.9 11 5.3 19.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 CDI87572.1 - 7.4 6.7 10.9 12 6.0 10.9 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 CDI87572.1 - 8.3 5.1 16.2 12 4.5 16.2 1.1 1 0 0 1 1 1 0 Presenilin sCache_2 PF17200.4 CDI87573.1 - 0.54 10.1 0.0 0.54 10.1 0.0 2.0 2 0 0 2 2 2 0 Single Cache domain 2 Presenilin PF01080.17 CDI87575.1 - 0.01 14.7 24.9 0.012 14.4 24.9 1.3 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CDI87575.1 - 0.41 10.6 14.8 0.53 10.2 14.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hid1 PF12722.7 CDI87575.1 - 0.49 8.5 27.9 0.5 8.4 27.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Raftlin PF15250.6 CDI87575.1 - 2.5 6.7 21.5 2.7 6.7 21.5 1.1 1 0 0 1 1 1 0 Raftlin GREB1 PF15782.5 CDI87575.1 - 3.1 4.8 33.7 3.3 4.7 33.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Nop14 PF04147.12 CDI87575.1 - 4.2 5.5 20.3 4.8 5.3 20.3 1.0 1 0 0 1 1 1 0 Nop14-like family SLC12 PF03522.15 CDI87575.1 - 9 5.2 23.7 11 4.9 23.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RskA PF10099.9 CDI87576.1 - 0.0008 19.8 0.0 0.0008 19.8 0.0 8.4 6 2 1 7 7 6 3 Anti-sigma-K factor rskA EOS1 PF12326.8 CDI87576.1 - 0.0011 19.0 0.3 1.4 8.8 0.0 4.0 3 2 0 3 3 3 1 N-glycosylation protein Med3 PF11593.8 CDI87576.1 - 0.0033 16.7 3.3 0.0033 16.7 3.3 10.0 7 2 1 8 8 3 2 Mediator complex subunit 3 fungal SUIM_assoc PF16619.5 CDI87576.1 - 0.0067 16.5 3.6 0.0067 16.5 3.6 8.6 6 1 0 6 6 5 3 Unstructured region C-term to UIM in Ataxin3 DDHD PF02862.17 CDI87576.1 - 0.0088 16.2 0.2 0.0088 16.2 0.2 4.9 4 1 0 4 4 3 1 DDHD domain LpxB PF02684.15 CDI87576.1 - 0.019 13.8 2.0 0.062 12.1 2.0 1.8 1 0 0 1 1 1 0 Lipid-A-disaccharide synthetase Folate_carrier PF01770.18 CDI87576.1 - 0.13 10.9 5.5 0.085 11.6 1.4 2.5 3 0 0 3 3 3 0 Reduced folate carrier Serinc PF03348.15 CDI87576.1 - 0.3 9.9 1.4 0.74 8.7 0.1 2.3 2 0 0 2 2 2 0 Serine incorporator (Serinc) Peroxin-13_N PF04088.13 CDI87576.1 - 3.2 8.0 14.0 0.38 11.0 1.3 4.3 4 0 0 4 4 4 0 Peroxin 13, N-terminal region Otopetrin PF03189.13 CDI87576.1 - 4.9 5.9 5.5 5.5 5.7 0.4 2.7 3 0 0 3 3 3 0 Otopetrin EPL1 PF10513.9 CDI87576.1 - 9.9 6.5 32.8 0.046 14.1 3.4 5.4 6 0 0 6 6 6 0 Enhancer of polycomb-like SUIM_assoc PF16619.5 CDI87578.1 - 2.1e-05 24.5 0.0 2.8e-05 24.1 0.0 1.4 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 IHABP4_N PF16174.5 CDI87578.1 - 0.036 14.7 6.0 0.056 14.1 6.0 1.4 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal PAT1 PF09770.9 CDI87578.1 - 0.24 9.6 7.3 0.27 9.4 7.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDC27 PF09507.10 CDI87578.1 - 0.7 9.2 11.1 0.92 8.8 11.1 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RskA PF10099.9 CDI87578.1 - 1.1 9.6 29.0 1.4 9.2 29.0 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI87578.1 - 3.5 7.5 17.4 4.1 7.3 17.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EBP50_C PF09007.11 CDI87579.1 - 1.9 9.5 18.2 2.1 9.3 18.2 1.1 1 0 0 1 1 1 0 EBP50, C-terminal KCNQ2_u3 PF16642.5 CDI87579.1 - 3.3 8.7 17.0 4.9 8.2 17.0 1.2 1 0 0 1 1 1 0 Unstructured region on Potassium channel subunit alpha KvLQT2 Rtf2 PF04641.12 CDI87579.1 - 4.1 6.7 20.6 4.3 6.6 20.6 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Presenilin PF01080.17 CDI87579.1 - 6.4 5.4 24.7 6.4 5.4 24.7 1.0 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI87579.1 - 6.7 6.7 20.6 7.1 6.6 20.6 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Connexin PF00029.19 CDI87579.1 - 7.3 6.3 15.2 9.4 5.9 15.2 1.3 1 0 0 1 1 1 0 Connexin Activator_LAG-3 PF11498.8 CDI87580.1 - 0.0026 16.8 7.9 0.0026 16.8 7.9 8.2 6 2 2 9 9 9 2 Transcriptional activator LAG-3 Adaptin_binding PF10199.9 CDI87580.1 - 0.0027 18.3 3.7 0.0027 18.3 3.7 7.1 4 3 0 4 4 4 1 Alpha and gamma adaptin binding protein p34 MukB_hinge PF16330.5 CDI87581.1 - 0.0023 17.7 1.6 0.0038 17.0 1.6 1.4 1 0 0 1 1 1 1 MukB hinge domain RskA PF10099.9 CDI87581.1 - 0.004 17.5 1.2 0.004 17.5 1.2 2.3 1 1 1 2 2 2 1 Anti-sigma-K factor rskA RRN3 PF05327.11 CDI87581.1 - 0.016 13.8 1.5 0.016 13.8 1.5 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 WGG PF10273.9 CDI87581.1 - 0.11 13.2 1.4 0.21 12.2 1.4 1.4 1 0 0 1 1 1 0 Pre-rRNA-processing protein TSR2 TetR_C_24 PF17932.1 CDI87581.1 - 0.13 12.6 0.9 0.28 11.5 0.9 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF3584 PF12128.8 CDI87581.1 - 0.17 9.4 13.8 0.18 9.3 13.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Caps_synth_GfcC PF06251.11 CDI87581.1 - 0.23 11.0 8.1 0.38 10.3 8.1 1.4 1 0 0 1 1 1 0 Capsule biosynthesis GfcC YnfE PF17452.2 CDI87581.1 - 0.27 11.6 4.0 0.57 10.5 4.0 1.5 1 0 0 1 1 1 0 Uncharacterized YnfE-like 5_nucleotid PF05761.14 CDI87581.1 - 0.59 9.0 5.4 0.78 8.6 5.4 1.1 1 0 0 1 1 1 0 5' nucleotidase family DUF1980 PF09323.10 CDI87581.1 - 1 9.2 3.8 1.5 8.7 3.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) OmpH PF03938.14 CDI87581.1 - 1.8 8.9 20.0 0.32 11.3 16.0 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) TMPIT PF07851.13 CDI87581.1 - 5.9 6.0 7.0 8.1 5.6 7.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein Ndc1_Nup PF09531.10 CDI87581.1 - 6.3 5.4 11.0 8.1 5.0 11.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SNARE PF05739.19 CDI87582.1 - 2.1e-10 40.4 1.2 2.1e-10 40.4 1.2 1.6 2 0 0 2 2 1 1 SNARE domain Syntaxin PF00804.25 CDI87582.1 - 2.2e-09 37.3 0.2 2.2e-09 37.3 0.2 1.8 2 0 0 2 2 2 1 Syntaxin DUF4577 PF15145.6 CDI87582.1 - 0.0051 16.9 0.3 0.0087 16.1 0.2 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4577) DUF1515 PF07439.11 CDI87582.1 - 0.0076 16.3 1.2 0.0095 16.0 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1515) TACC_C PF05010.14 CDI87582.1 - 0.0078 16.0 4.3 0.0097 15.7 4.3 1.0 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF846 PF05832.12 CDI87582.1 - 0.0079 16.2 0.2 0.011 15.8 0.2 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Helo_like_N PF17111.5 CDI87582.1 - 0.0086 15.5 0.3 0.011 15.2 0.3 1.0 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins Fusion_gly PF00523.18 CDI87582.1 - 0.011 14.0 0.7 0.014 13.6 0.7 1.2 1 1 0 1 1 1 0 Fusion glycoprotein F0 RIFIN PF02009.16 CDI87582.1 - 0.013 15.5 1.3 0.014 15.3 1.3 1.1 1 0 0 1 1 1 0 Rifin CRA PF06589.11 CDI87582.1 - 0.035 14.2 0.1 0.037 14.1 0.1 1.2 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) DUF16 PF01519.16 CDI87582.1 - 0.045 14.2 3.0 0.058 13.9 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 DUF1640 PF07798.11 CDI87582.1 - 0.046 13.8 2.7 0.06 13.4 2.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) Z1 PF10593.9 CDI87582.1 - 0.046 13.2 0.8 0.055 13.0 0.8 1.1 1 0 0 1 1 1 0 Z1 domain Orf78 PF06024.12 CDI87582.1 - 0.048 14.0 1.0 0.064 13.6 1.0 1.5 1 1 0 1 1 1 0 Orf78 (ac78) T2SSF PF00482.23 CDI87582.1 - 0.057 13.4 5.2 0.39 10.7 5.2 1.9 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF2207 PF09972.9 CDI87582.1 - 0.059 12.1 0.2 0.057 12.2 0.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EMP24_GP25L PF01105.24 CDI87582.1 - 0.061 13.3 3.9 0.1 12.6 3.8 1.4 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Med2 PF11214.8 CDI87582.1 - 0.076 13.2 1.4 0.094 12.9 1.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 2 DUF5383 PF17355.2 CDI87582.1 - 0.085 13.2 1.4 0.1 13.0 1.4 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF5383) VIT1 PF01988.19 CDI87582.1 - 0.097 12.5 0.4 0.12 12.3 0.4 1.0 1 0 0 1 1 1 0 VIT family DUF2116 PF09889.9 CDI87582.1 - 0.11 12.4 0.5 0.22 11.5 0.5 1.5 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF1043 PF06295.12 CDI87582.1 - 0.24 11.4 4.9 0.34 10.9 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Flp1_like PF16982.5 CDI87582.1 - 0.43 10.0 5.9 0.72 9.3 5.9 1.4 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain DUF4231 PF14015.6 CDI87582.1 - 0.66 10.5 4.1 1.4 9.5 1.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) SR-25 PF10500.9 CDI87583.1 - 0.0049 16.5 47.7 0.0053 16.4 25.1 2.6 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein Utp14 PF04615.13 CDI87583.1 - 0.018 13.7 22.3 0.016 13.8 18.0 2.2 2 0 0 2 2 2 0 Utp14 protein SPX PF03105.19 CDI87583.1 - 0.098 12.6 16.1 1.7 8.5 11.2 2.5 2 0 0 2 2 2 0 SPX domain Neur_chan_memb PF02932.16 CDI87583.1 - 0.13 12.4 11.1 0.074 13.1 7.7 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Cwf_Cwc_15 PF04889.12 CDI87583.1 - 0.43 10.3 0.0 0.43 10.3 0.0 3.3 2 1 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Velvet PF11754.8 CDI87583.1 - 4 7.3 25.6 0.15 11.9 13.0 2.5 2 1 0 2 2 2 0 Velvet factor Profilin PF00235.19 CDI87585.1 - 1.6e-16 60.7 1.0 2.8e-16 60.0 1.0 1.4 1 1 0 1 1 1 1 Profilin ThiJ_like PF17124.5 CDI87585.1 - 0.02 14.6 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 ThiJ/PfpI family-like DUF2957 PF11170.8 CDI87586.1 - 0.081 11.8 6.5 4.6 6.0 4.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2957) DUF2207 PF09972.9 CDI87586.1 - 0.24 10.1 0.2 0.78 8.4 0.2 1.8 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) RskA PF10099.9 CDI87587.1 - 0.00018 21.9 0.0 0.00018 21.9 0.0 3.9 1 1 1 3 3 3 1 Anti-sigma-K factor rskA Rtt102p PF09510.10 CDI87587.1 - 0.34 11.1 0.0 0.34 11.1 0.0 3.8 4 0 0 4 4 4 0 Rtt102p-like transcription regulator protein RSB_motif PF16294.5 CDI87587.1 - 1.6 9.1 15.3 4.8 7.5 0.2 3.9 4 0 0 4 4 4 0 RNSP1-SAP18 binding (RSB) motif SbcCD_C PF13558.6 CDI87587.1 - 2.4 8.4 0.0 2.4 8.4 0.0 4.6 3 2 1 4 4 4 0 Putative exonuclease SbcCD, C subunit SURF6 PF04935.12 CDI87588.1 - 0.78 9.5 14.1 1.2 8.8 14.1 1.3 1 0 0 1 1 1 0 Surfeit locus protein 6 Robl_LC7 PF03259.17 CDI87588.1 - 1.4 8.8 4.1 7 6.5 0.2 2.4 2 0 0 2 2 2 0 Roadblock/LC7 domain DUF5427 PF10310.9 CDI87588.1 - 1.4 7.8 17.8 2.1 7.2 17.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) RskA PF10099.9 CDI87588.1 - 2.9 8.1 31.0 1.5e+02 2.6 31.0 2.3 1 1 0 1 1 1 0 Anti-sigma-K factor rskA PAT1 PF09770.9 CDI87588.1 - 3.6 5.7 28.0 4.3 5.5 28.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 CDI87588.1 - 3.8 6.2 9.8 4.7 5.9 9.8 1.2 1 0 0 1 1 1 0 Presenilin Ribosomal_60s PF00428.19 CDI87589.1 - 7.2 7.3 17.8 0.64 10.6 9.2 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein Cwf_Cwc_15 PF04889.12 CDI87590.1 - 0.18 11.5 12.5 0.028 14.2 8.6 1.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SPX PF03105.19 CDI87590.1 - 1.8 8.4 9.8 2 8.2 9.8 1.2 1 0 0 1 1 1 0 SPX domain EphA2_TM PF14575.6 CDI87590.1 - 5.5 7.9 8.2 18 6.3 1.4 2.6 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain ANAPC_CDC26 PF10471.9 CDI87591.1 - 0.0052 17.6 1.3 0.0052 17.6 1.3 6.5 4 2 2 7 7 7 1 Anaphase-promoting complex APC subunit CDC26 SR-25 PF10500.9 CDI87591.1 - 0.0072 16.0 10.5 0.0072 16.0 10.5 5.2 3 1 1 4 4 4 3 Nuclear RNA-splicing-associated protein Pox_A12 PF04651.13 CDI87591.1 - 0.086 12.9 0.2 0.086 12.9 0.2 3.1 3 0 0 3 3 3 0 Poxvirus A12 protein RIFIN PF02009.16 CDI87591.1 - 1.5 8.6 20.9 0.55 10.1 6.7 2.5 3 0 0 3 3 3 0 Rifin BUD22 PF09073.10 CDI87592.1 - 0.11 11.9 24.6 0.13 11.6 24.6 1.0 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 CDI87592.1 - 0.21 9.7 29.2 0.28 9.4 29.2 1.1 1 0 0 1 1 1 0 Nop14-like family BAF1_ABF1 PF04684.13 CDI87592.1 - 0.24 10.4 8.3 0.28 10.2 8.3 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SDA1 PF05285.12 CDI87592.1 - 0.25 10.8 32.2 0.3 10.4 32.2 1.1 1 0 0 1 1 1 0 SDA1 Tox-WTIP PF15654.6 CDI87592.1 - 0.39 11.1 2.5 6.3 7.3 0.2 2.3 1 1 1 2 2 2 0 Toxin with a conserved tryptophan and TIP tripeptide motif CCSAP PF15748.5 CDI87592.1 - 0.74 9.9 10.4 1 9.5 10.4 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated RNA_polI_A34 PF08208.11 CDI87592.1 - 2.9 7.9 22.3 4.1 7.5 22.3 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Presenilin PF01080.17 CDI87592.1 - 2.9 6.5 9.4 4.3 6.0 9.4 1.3 1 0 0 1 1 1 0 Presenilin INSIG PF07281.12 CDI87592.1 - 3.5 7.2 4.4 13 5.4 2.9 2.0 1 1 1 2 2 2 0 Insulin-induced protein (INSIG) DUF4604 PF15377.6 CDI87592.1 - 3.7 7.9 25.6 6.5 7.2 25.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Spc7_N PF15402.6 CDI87592.1 - 4.2 5.5 26.1 4.8 5.3 26.1 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF4045 PF13254.6 CDI87592.1 - 5.9 6.4 7.9 7.8 6.0 7.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CENP-N PF05238.13 CDI87592.1 - 6.3 6.0 7.0 7.5 5.7 7.0 1.0 1 0 0 1 1 1 0 Kinetochore protein CHL4 like MIF4G_like_2 PF09090.11 CDI87592.1 - 6.3 6.2 13.8 8.2 5.8 13.8 1.2 1 0 0 1 1 1 0 MIF4G like ETF_alpha PF00766.19 CDI87592.1 - 8.7 6.4 10.9 9.9 6.3 0.8 3.0 2 1 1 3 3 3 0 Electron transfer flavoprotein FAD-binding domain PA26 PF04636.13 CDI87592.1 - 10 4.9 8.5 12 4.6 8.5 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Sugar_tr PF00083.24 CDI87594.1 - 0.14 11.0 5.3 0.16 10.8 5.3 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter Spt20 PF12090.8 CDI87594.1 - 0.21 11.1 35.8 0.24 11.0 35.8 1.2 1 0 0 1 1 1 0 Spt20 family TFB6 PF17110.5 CDI87594.1 - 0.48 10.1 8.1 0.51 10.1 8.1 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Itfg2 PF15907.5 CDI87594.1 - 0.55 9.2 10.2 0.57 9.2 10.2 1.0 1 0 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 CRF1 PF10380.9 CDI87594.1 - 0.58 10.5 6.0 0.72 10.2 6.0 1.2 1 0 0 1 1 1 0 Transcription factor CRF1 CNDH2_M PF16869.5 CDI87594.1 - 0.58 10.8 9.2 0.63 10.7 9.2 1.1 1 0 0 1 1 1 0 PF16858 XRN_N PF03159.18 CDI87594.1 - 1.2 8.6 13.5 1.2 8.5 13.5 1.0 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus CobT PF06213.12 CDI87594.1 - 1.5 8.1 18.3 1.4 8.3 18.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT EIIBC-GUT_N PF03612.14 CDI87594.1 - 2 8.1 14.2 1.9 8.2 14.2 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Pex14_N PF04695.13 CDI87594.1 - 2 9.0 22.3 2.2 8.9 22.3 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CPSF100_C PF13299.6 CDI87594.1 - 2.1 8.5 12.9 2 8.6 12.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 CDI87594.1 - 2.1 8.1 16.4 2.1 8.1 16.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Orf78 PF06024.12 CDI87594.1 - 2.2 8.6 8.1 2.4 8.5 8.1 1.3 1 0 0 1 1 1 0 Orf78 (ac78) AIF_C PF14721.6 CDI87594.1 - 2.2 8.6 11.7 2.5 8.5 11.7 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Coilin_N PF15862.5 CDI87594.1 - 2.2 8.1 18.8 2.6 7.9 18.8 1.3 1 0 0 1 1 1 0 Coilin N-terminus SpoIIP PF07454.11 CDI87594.1 - 2.3 7.6 17.7 2.3 7.6 17.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) G0-G1_switch_2 PF15103.6 CDI87594.1 - 2.5 8.6 11.5 2.7 8.5 11.5 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 DUF1764 PF08576.10 CDI87594.1 - 2.6 9.0 18.4 3.3 8.7 18.4 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Connexin PF00029.19 CDI87594.1 - 2.8 7.6 13.4 2.7 7.7 13.4 1.1 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 CDI87594.1 - 3.1 5.6 15.4 2.8 5.7 15.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DDHD PF02862.17 CDI87594.1 - 3.3 7.8 15.2 3.3 7.8 15.2 1.0 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 CDI87594.1 - 3.4 6.3 18.1 3.3 6.4 18.1 1.0 1 0 0 1 1 1 0 Presenilin TERB2 PF15101.6 CDI87594.1 - 4.2 7.4 20.6 4.1 7.4 20.6 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 eIF-3_zeta PF05091.12 CDI87594.1 - 4.4 6.2 21.2 4.2 6.2 21.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_S49_N PF08496.10 CDI87594.1 - 4.6 7.3 15.6 4.8 7.2 15.6 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Kei1 PF08552.11 CDI87594.1 - 5.4 6.9 8.9 5.2 6.9 8.9 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 EOS1 PF12326.8 CDI87594.1 - 5.6 6.9 10.4 5.5 6.9 10.4 1.1 1 0 0 1 1 1 0 N-glycosylation protein Sec62 PF03839.16 CDI87594.1 - 5.9 6.3 12.9 5.5 6.4 12.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Peroxin-13_N PF04088.13 CDI87594.1 - 6 7.1 10.5 5.8 7.2 10.5 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region CLN3 PF02487.17 CDI87594.1 - 6.2 5.8 11.9 6 5.8 11.9 1.0 1 0 0 1 1 1 0 CLN3 protein TFIIA PF03153.13 CDI87594.1 - 6.5 6.6 32.9 6.4 6.7 32.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2828 PF11443.8 CDI87594.1 - 6.9 4.6 16.2 6.5 4.7 16.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PPL5 PF18168.1 CDI87594.1 - 7.1 5.8 11.6 6.6 5.9 11.6 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF1980 PF09323.10 CDI87594.1 - 8.3 6.3 12.7 7.3 6.5 12.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Suf PF05843.14 CDI87594.1 - 8.9 6.2 20.0 9.3 6.1 20.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Folate_carrier PF01770.18 CDI87594.1 - 9.7 4.8 10.2 9.3 4.9 10.2 1.0 1 0 0 1 1 1 0 Reduced folate carrier Utp14 PF04615.13 CDI87595.1 - 0.00011 21.0 0.3 0.00011 21.0 0.3 15.6 5 3 11 16 16 16 1 Utp14 protein SARAF PF06682.12 CDI87595.1 - 0.0021 17.8 16.3 0.0021 17.8 16.3 25.8 9 8 13 23 23 23 3 SOCE-associated regulatory factor of calcium homoeostasis RskA PF10099.9 CDI87596.1 - 0.00016 22.0 12.0 0.00016 22.0 12.0 3.6 1 1 2 3 3 3 1 Anti-sigma-K factor rskA Draxin PF15550.6 CDI87596.1 - 3.8 7.3 28.1 0.18 11.6 20.1 2.1 2 0 0 2 2 2 0 Draxin Choline_kinase PF01633.20 CDI87597.1 - 4.5e-24 85.2 0.0 7.4e-19 68.2 0.0 6.7 4 2 3 7 7 7 2 Choline/ethanolamine kinase DUF2722 PF10846.8 CDI87598.1 - 1.8e-06 27.2 0.0 1.8e-06 27.2 0.0 2.4 2 1 1 3 3 3 1 Protein of unknown function (DUF2722) Musclin PF11037.8 CDI87598.1 - 0.0074 16.2 0.2 0.034 14.1 0.2 2.2 1 0 0 1 1 1 1 Insulin-resistance promoting peptide in skeletal muscle TFIIA PF03153.13 CDI87598.1 - 0.018 15.0 29.7 0.35 10.8 13.9 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Laminin_G_3 PF13385.6 CDI87598.1 - 0.035 14.3 0.0 0.099 12.8 0.0 1.7 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily SR-25 PF10500.9 CDI87598.1 - 0.16 11.6 23.7 0.47 10.0 2.2 3.4 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein DDHD PF02862.17 CDI87598.1 - 0.29 11.2 0.1 0.29 11.2 0.1 2.7 2 1 0 2 2 1 0 DDHD domain DUF4736 PF15883.5 CDI87598.1 - 1 9.1 7.8 2.3 7.9 7.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4736) Spt20 PF12090.8 CDI87598.1 - 2.4 7.7 32.9 0.84 9.2 21.9 2.5 2 0 0 2 2 2 0 Spt20 family DUF4746 PF15928.5 CDI87598.1 - 2.6 7.4 7.0 6.8 6.0 1.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Med15 PF09606.10 CDI87598.1 - 2.9 6.4 23.3 0.17 10.5 14.1 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2367 PF10164.9 CDI87598.1 - 7.2 7.2 5.4 19 5.8 1.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2367) Mito_carr PF00153.27 CDI87599.1 - 5e-52 173.8 0.3 1.6e-18 66.4 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Presenilin PF01080.17 CDI87600.1 - 0.0033 16.2 29.0 0.0033 16.2 29.0 4.4 4 1 0 4 4 4 2 Presenilin RskA PF10099.9 CDI87600.1 - 0.01 16.1 6.8 0.01 16.1 6.8 8.4 2 2 4 6 6 6 0 Anti-sigma-K factor rskA Apt1 PF10351.9 CDI87600.1 - 5.7 5.7 97.7 0.16 10.8 13.4 4.3 4 0 0 4 4 4 0 Golgi-body localisation protein domain CDC45 PF02724.14 CDI87601.1 - 2.4 6.3 35.9 3 6.0 35.9 1.1 1 0 0 1 1 1 0 CDC45-like protein GREB1 PF15782.5 CDI87601.1 - 2.5 5.1 49.7 3.1 4.8 49.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PAP2 PF01569.21 CDI87601.1 - 2.7 7.8 9.6 88 2.9 9.6 2.6 1 1 0 1 1 1 0 PAP2 superfamily Macoilin PF09726.9 CDI87601.1 - 2.9 6.4 40.3 4 5.9 40.3 1.2 1 0 0 1 1 1 0 Macoilin family Cellulose_synt PF03552.14 CDI87601.1 - 3.4 6.0 12.5 3.7 5.9 12.5 1.3 1 0 0 1 1 1 0 Cellulose synthase Miga PF10265.9 CDI87601.1 - 3.6 6.5 24.4 4.5 6.1 24.4 1.3 1 0 0 1 1 1 0 Mitoguardin Smg8_Smg9 PF10220.9 CDI87601.1 - 4.5 5.5 30.9 4.6 5.4 30.9 1.3 1 0 0 1 1 1 0 Smg8_Smg9 Caldesmon PF02029.15 CDI87601.1 - 7.1 5.3 45.0 8.4 5.0 45.0 1.0 1 0 0 1 1 1 0 Caldesmon Spt20 PF12090.8 CDI87602.1 - 1.6 8.3 5.9 2.3 7.8 5.9 1.2 1 0 0 1 1 1 0 Spt20 family Aminotran_5 PF00266.19 CDI87603.1 - 4e-16 58.9 1.5 4e-16 58.9 1.5 2.1 1 1 1 2 2 2 1 Aminotransferase class-V Dehydrin PF00257.19 CDI87603.1 - 0.01 16.4 2.8 0.01 16.4 2.8 2.5 2 1 0 2 2 2 0 Dehydrin SOSSC PF15925.5 CDI87603.1 - 3.1 9.1 11.6 6 8.2 1.8 2.3 2 0 0 2 2 2 0 SOSS complex subunit C RskA PF10099.9 CDI87603.1 - 4.9 7.4 35.9 0.16 12.3 9.9 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA NUDE_C PF04880.13 CDI87603.1 - 6.2 7.3 11.8 7.4 7.0 4.8 2.1 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region Methyltrans_RNA PF04452.14 CDI87604.1 - 1.1e-27 96.8 0.0 9.7e-13 48.0 0.0 2.2 2 0 0 2 2 2 2 RNA methyltransferase AbiEi_3 PF11459.8 CDI87604.1 - 0.018 14.8 0.1 0.032 13.9 0.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system SUIM_assoc PF16619.5 CDI87604.1 - 0.051 13.6 6.2 0.45 10.6 3.0 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Ribosomal_60s PF00428.19 CDI87604.1 - 4.9 7.8 29.6 0.99 10.0 2.8 3.3 3 0 0 3 3 3 0 60s Acidic ribosomal protein RsfS PF02410.15 CDI87605.1 - 8.7e-13 48.5 0.0 5e-12 46.1 0.0 2.2 2 0 0 2 2 2 1 Ribosomal silencing factor during starvation PAS_4 PF08448.10 CDI87605.1 - 0.74 10.1 6.0 0.2 11.9 1.0 2.5 1 1 1 2 2 2 0 PAS fold SR-25 PF10500.9 CDI87605.1 - 1.8 8.1 18.2 0.019 14.6 8.7 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Methyltransf_12 PF08242.12 CDI87607.1 - 0.97 10.2 2.8 30 5.4 0.2 3.2 2 0 0 2 2 2 0 Methyltransferase domain SBP_bac_6 PF13343.6 CDI87607.1 - 3.5 7.0 6.3 0.75 9.2 0.3 2.4 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein Activator_LAG-3 PF11498.8 CDI87608.1 - 0.0012 18.0 20.9 0.0017 17.4 20.9 1.2 1 0 0 1 1 1 1 Transcriptional activator LAG-3 Collagen PF01391.18 CDI87609.1 - 2e-12 46.6 58.4 3.3e-08 33.1 26.2 5.9 6 1 1 7 7 7 2 Collagen triple helix repeat (20 copies) Spt20 PF12090.8 CDI87609.1 - 0.0012 18.5 28.1 0.0012 18.5 28.1 3.4 3 0 0 3 3 3 2 Spt20 family Velvet PF11754.8 CDI87609.1 - 3.6 7.4 24.6 1.2 9.1 1.3 3.2 3 0 0 3 3 3 0 Velvet factor SEFIR PF08357.11 CDI87613.1 - 0.1 12.9 7.3 0.057 13.7 2.3 2.0 2 0 0 2 2 2 0 SEFIR domain DUF1180 PF06679.12 CDI87613.1 - 0.11 12.9 4.1 0.14 12.5 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Porph_ging PF09697.10 CDI87613.1 - 0.15 12.6 3.5 0.21 12.1 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) DUF1892 PF08987.10 CDI87613.1 - 0.19 11.9 4.9 0.066 13.4 2.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1892) Peptidase_S64 PF08192.11 CDI87613.1 - 0.29 9.6 15.4 0.35 9.3 15.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 CDK2AP PF09806.9 CDI87613.1 - 0.48 10.4 14.8 0.79 9.7 14.8 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DUF4667 PF15700.5 CDI87613.1 - 0.51 10.4 18.1 0.64 10.1 18.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) TFIIA PF03153.13 CDI87613.1 - 0.52 10.3 34.1 0.8 9.6 34.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4718 PF15842.5 CDI87613.1 - 0.77 9.5 15.6 1.2 8.9 15.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4718) ALMT PF11744.8 CDI87613.1 - 1.1 8.0 14.2 1.3 7.8 14.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter GREB1 PF15782.5 CDI87613.1 - 1.4 5.9 15.3 1.5 5.8 15.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CLN3 PF02487.17 CDI87613.1 - 1.9 7.4 7.2 2.5 7.1 7.2 1.2 1 0 0 1 1 1 0 CLN3 protein Ndc1_Nup PF09531.10 CDI87613.1 - 3.4 6.3 17.8 3.9 6.0 17.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SLC12 PF03522.15 CDI87613.1 - 3.5 6.6 15.3 4.3 6.3 15.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CAML PF14963.6 CDI87613.1 - 3.9 7.5 8.9 4.8 7.2 8.9 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Miga PF10265.9 CDI87613.1 - 4 6.3 15.8 4.9 6.0 15.8 1.0 1 0 0 1 1 1 0 Mitoguardin XRN_N PF03159.18 CDI87613.1 - 4 6.8 8.9 5.3 6.4 8.9 1.2 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus Gti1_Pac2 PF09729.9 CDI87613.1 - 5 7.2 13.0 6.9 6.7 13.0 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Apt1 PF10351.9 CDI87613.1 - 5.6 5.7 15.4 6.8 5.4 15.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain PNISR PF15996.5 CDI87613.1 - 8.4 6.6 22.2 15 5.8 22.2 1.4 1 1 0 1 1 1 0 Arginine/serine-rich protein PNISR Spt20 PF12090.8 CDI87614.1 - 0.55 9.8 10.3 0.55 9.8 10.3 1.0 1 0 0 1 1 1 0 Spt20 family LZ_Tnp_IS66 PF13007.7 CDI87614.1 - 4.3 8.2 12.6 0.22 12.3 6.0 1.9 1 1 1 2 2 2 0 Transposase C of IS166 homeodomain Nop14 PF04147.12 CDI87615.1 - 0.38 8.9 28.3 0.15 10.2 5.3 2.1 2 0 0 2 2 2 0 Nop14-like family Nop53 PF07767.11 CDI87615.1 - 3.1 7.1 30.8 1.3 8.4 21.2 2.1 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) SpoIIP PF07454.11 CDI87615.1 - 3.7 6.9 26.1 2.2 7.7 16.2 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) PA26 PF04636.13 CDI87615.1 - 3.7 6.4 25.4 1.1 8.1 5.7 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Spt5_N PF11942.8 CDI87615.1 - 5.4 8.1 23.7 23 6.0 17.0 2.7 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Isy1 PF06246.12 CDI87615.1 - 5.5 6.5 22.1 0.7 9.4 13.1 2.3 2 0 0 2 2 2 0 Isy1-like splicing family DUF3405 PF11885.8 CDI87615.1 - 9.9 4.6 18.1 2.4 6.7 9.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3405) RskA PF10099.9 CDI87616.1 - 0.0024 18.2 11.5 0.0024 18.2 11.5 10.5 1 1 7 8 8 8 1 Anti-sigma-K factor rskA DUF3439 PF11921.8 CDI87616.1 - 0.047 13.7 13.5 0.09 12.7 6.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Ni_hydr_CYTB PF01292.20 CDI87616.1 - 4.4 6.9 6.5 0.52 9.9 0.0 2.7 3 1 1 4 4 4 0 Prokaryotic cytochrome b561 UNC80 PF15778.5 CDI87618.1 - 0.079 12.6 2.0 0.11 12.0 2.0 1.2 1 0 0 1 1 1 0 Cation channel complex component UNC80 DUF5331 PF17265.2 CDI87618.1 - 0.18 11.5 0.7 0.35 10.6 0.7 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5331) TPR_7 PF13176.6 CDI87619.1 - 0.0066 16.4 4.2 27 5.1 0.8 4.1 3 0 0 3 3 3 3 Tetratricopeptide repeat MIT PF04212.18 CDI87621.1 - 0.56 10.3 5.5 1.6 8.9 0.6 2.9 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain RAP1 PF07218.11 CDI87622.1 - 2.2e-05 23.0 3.5 3.1e-05 22.5 3.5 1.1 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) AF-4 PF05110.13 CDI87622.1 - 0.18 9.8 30.1 0.24 9.4 30.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein AAA_23 PF13476.6 CDI87622.1 - 1.5 9.3 15.5 0.18 12.3 9.6 2.0 2 0 0 2 2 2 0 AAA domain Hamartin PF04388.12 CDI87622.1 - 3.3 6.3 20.5 4.8 5.7 20.5 1.1 1 0 0 1 1 1 0 Hamartin protein PRIMA1 PF16101.5 CDI87623.1 - 0.65 10.0 6.7 5.2 7.1 6.0 2.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Caldesmon PF02029.15 CDI87624.1 - 0.0048 15.7 7.8 0.0048 15.7 7.8 1.9 2 0 0 2 2 2 1 Caldesmon AI-2E_transport PF01594.16 CDI87624.1 - 0.044 12.9 0.0 0.062 12.4 0.0 1.1 1 0 0 1 1 1 0 AI-2E family transporter LMBR1 PF04791.16 CDI87624.1 - 0.087 11.7 0.3 0.13 11.2 0.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein CSG2 PF16965.5 CDI87624.1 - 0.28 10.1 1.8 0.45 9.4 1.8 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Ureide_permease PF07168.11 CDI87624.1 - 0.3 9.8 1.3 0.66 8.7 1.3 1.5 1 0 0 1 1 1 0 Ureide permease DUF2721 PF11026.8 CDI87624.1 - 0.35 10.8 2.8 0.94 9.4 2.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2721) Peptidase_S49_N PF08496.10 CDI87624.1 - 0.9 9.6 15.6 2.6 8.1 9.8 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal FemAB PF02388.16 CDI87624.1 - 1 8.2 9.7 2 7.2 9.7 1.4 1 0 0 1 1 1 0 FemAB family HAUS6_N PF14661.6 CDI87624.1 - 1.3 8.6 16.7 0.054 13.1 11.0 1.6 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Roughex PF06020.11 CDI87624.1 - 2.3 7.2 8.3 5.8 5.9 8.3 1.6 1 0 0 1 1 1 0 Drosophila roughex protein Neur_chan_memb PF02932.16 CDI87624.1 - 2.4 8.1 9.4 0.56 10.2 2.8 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SpoIIP PF07454.11 CDI87624.1 - 2.8 7.4 10.1 0.21 11.0 5.0 1.6 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 CDI87624.1 - 3 7.6 10.5 0.33 10.7 5.7 1.7 2 0 0 2 2 2 0 Connexin UNC-79 PF14776.6 CDI87624.1 - 3.2 6.4 5.3 4.8 5.8 5.3 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 DUF2052 PF09747.9 CDI87624.1 - 3.7 7.6 16.5 0.15 12.2 4.6 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Suf PF05843.14 CDI87624.1 - 4.5 7.2 17.1 0.18 11.7 8.1 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Chorein_N PF12624.7 CDI87625.1 - 7.5e-08 32.5 0.4 7.5e-08 32.5 0.4 15.6 14 3 1 15 15 15 1 N-terminal region of Chorein or VPS13 TFIIA PF03153.13 CDI87625.1 - 0.00075 19.6 25.0 0.00075 19.6 25.0 13.4 3 2 7 11 11 11 2 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI87626.1 - 8.7e-05 22.9 6.2 8.7e-05 22.9 6.2 8.2 4 2 3 7 7 7 4 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI87627.1 - 0.0041 16.8 7.8 0.0041 16.8 7.8 7.4 3 2 3 6 6 6 1 Nuclear RNA-splicing-associated protein DUF4484 PF14831.6 CDI87628.1 - 0.086 12.9 21.7 0.11 12.6 21.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) DUF2428 PF10350.9 CDI87628.1 - 0.33 10.2 18.1 0.49 9.6 18.1 1.4 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) SARAF PF06682.12 CDI87628.1 - 1 8.9 20.2 1.3 8.6 20.2 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis PRC2_HTH_1 PF18118.1 CDI87628.1 - 1.2 10.0 24.9 0.25 12.2 7.0 2.1 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain PA26 PF04636.13 CDI87628.1 - 1.7 7.5 23.4 1.8 7.4 23.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CDC45 PF02724.14 CDI87628.1 - 2 6.6 22.6 2.6 6.2 22.6 1.3 1 0 0 1 1 1 0 CDC45-like protein Auxin_canalis PF05703.11 CDI87628.1 - 3.1 7.7 22.0 4.3 7.2 22.0 1.2 1 0 0 1 1 1 0 Auxin canalisation PBP1_TM PF14812.6 CDI87628.1 - 4.5 7.7 16.3 5.8 7.4 3.8 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SLC12 PF03522.15 CDI87628.1 - 5.1 6.0 31.7 5.7 5.9 31.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Gti1_Pac2 PF09729.9 CDI87628.1 - 5.4 7.1 29.6 0.079 13.0 6.7 2.0 2 0 0 2 2 2 0 Gti1/Pac2 family XAP5 PF04921.14 CDI87628.1 - 5.6 6.7 24.3 6.5 6.5 24.3 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator EFTUD2 PF16004.5 CDI87628.1 - 9 6.9 30.8 3.7 8.1 11.7 2.1 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus RskA PF10099.9 CDI87630.1 - 0.0025 18.1 10.0 0.0025 18.1 10.0 4.0 1 1 2 3 3 2 1 Anti-sigma-K factor rskA TAP42 PF04177.12 CDI87630.1 - 0.0034 16.5 4.5 0.0046 16.1 4.5 1.2 1 0 0 1 1 1 1 TAP42-like family SseC PF04888.12 CDI87630.1 - 0.0061 16.2 17.8 0.0061 16.2 17.8 3.0 2 1 0 2 2 1 1 Secretion system effector C (SseC) like family TFIIA PF03153.13 CDI87630.1 - 0.021 14.8 29.3 0.028 14.4 29.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tau95_N PF17682.1 CDI87630.1 - 0.044 14.0 0.6 0.084 13.1 0.6 1.4 1 0 0 1 1 1 0 Tau95 Triple barrel domain Dynamin_N PF00350.23 CDI87630.1 - 0.14 12.2 2.1 0.27 11.3 2.1 1.4 1 0 0 1 1 1 0 Dynamin family TFIIIC_sub6 PF10419.9 CDI87630.1 - 0.58 10.1 4.0 0.94 9.4 3.9 1.5 1 1 0 1 1 1 0 TFIIIC subunit triple barrel domain SAPS PF04499.15 CDI87630.1 - 0.72 8.6 5.2 0.9 8.2 5.2 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4834 PF16118.5 CDI87630.1 - 0.75 10.8 9.0 0.31 12.0 4.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF2052 PF09747.9 CDI87630.1 - 2.2 8.4 11.3 1.5 8.9 5.2 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Connexin PF00029.19 CDI87630.1 - 4.1 7.1 5.4 1.6 8.5 3.0 1.5 2 0 0 2 2 2 0 Connexin Activator_LAG-3 PF11498.8 CDI87630.1 - 6.4 5.6 25.3 13 4.6 25.3 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SR-25 PF10500.9 CDI87631.1 - 0.74 9.4 34.8 0.015 14.9 27.3 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SR-25 PF10500.9 CDI87632.1 - 1.2e-06 28.3 6.2 1.3e-06 28.2 6.2 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI87632.1 - 2.5e-05 23.4 13.1 2.5e-05 23.4 13.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF4614 PF15391.6 CDI87632.1 - 0.0041 17.2 8.2 0.0044 17.0 8.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4614) Velvet PF11754.8 CDI87632.1 - 0.0078 16.2 4.7 0.0079 16.2 4.7 1.1 1 0 0 1 1 1 1 Velvet factor CCSAP PF15748.5 CDI87632.1 - 0.024 14.8 9.6 0.025 14.8 9.6 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF3619 PF12279.8 CDI87632.1 - 0.026 14.9 2.8 0.033 14.5 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) Pex14_N PF04695.13 CDI87632.1 - 0.032 14.9 11.7 0.041 14.5 11.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Bul1_N PF04425.12 CDI87632.1 - 0.034 12.9 2.9 0.033 13.0 2.9 1.1 1 0 0 1 1 1 0 Bul1 N terminus NPR3 PF03666.13 CDI87632.1 - 0.05 12.4 5.6 0.042 12.6 5.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Mcm10 PF09332.11 CDI87632.1 - 0.055 12.9 6.8 0.063 12.7 6.8 1.1 1 0 0 1 1 1 0 Mcm10 replication factor DDHD PF02862.17 CDI87632.1 - 0.082 13.1 5.7 0.084 13.0 5.7 1.1 1 0 0 1 1 1 0 DDHD domain Med15 PF09606.10 CDI87632.1 - 0.082 11.6 15.4 0.094 11.4 15.4 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Zip PF02535.22 CDI87632.1 - 0.1 11.8 1.1 0.093 11.9 1.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CobT PF06213.12 CDI87632.1 - 0.1 12.0 12.6 0.12 11.8 12.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SpoIIP PF07454.11 CDI87632.1 - 0.11 11.9 4.8 0.1 12.0 4.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Roughex PF06020.11 CDI87632.1 - 0.14 11.2 11.3 0.19 10.8 11.3 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Band_3_cyto PF07565.13 CDI87632.1 - 0.19 11.5 4.1 0.17 11.7 4.1 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Presenilin PF01080.17 CDI87632.1 - 0.26 10.0 10.1 0.26 10.0 10.1 1.1 1 0 0 1 1 1 0 Presenilin EIIBC-GUT_N PF03612.14 CDI87632.1 - 0.36 10.6 5.0 0.43 10.3 5.0 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF5521 PF17659.1 CDI87632.1 - 0.53 8.1 8.5 0.64 7.8 8.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5521) Spore_coat_CotO PF14153.6 CDI87632.1 - 0.6 10.0 11.9 0.77 9.7 11.9 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Ureide_permease PF07168.11 CDI87632.1 - 0.91 8.2 3.0 1.1 8.0 3.0 1.1 1 0 0 1 1 1 0 Ureide permease Suf PF05843.14 CDI87632.1 - 0.96 9.4 12.0 1.1 9.2 12.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) EFTUD2 PF16004.5 CDI87632.1 - 0.97 10.0 10.3 0.12 13.0 6.7 1.4 2 0 0 2 2 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus CPSF100_C PF13299.6 CDI87632.1 - 1 9.6 6.5 1.2 9.3 6.5 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SMYLE_N PF18615.1 CDI87632.1 - 1.3 8.5 9.4 1.7 8.1 9.4 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Med3 PF11593.8 CDI87632.1 - 1.3 8.1 16.2 1.6 7.8 16.2 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Peptidase_S64 PF08192.11 CDI87632.1 - 1.5 7.2 8.0 1.5 7.2 8.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 Ndc1_Nup PF09531.10 CDI87632.1 - 1.6 7.3 6.1 1.6 7.3 6.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Neur_chan_memb PF02932.16 CDI87632.1 - 2.3 8.2 6.4 2.9 7.9 6.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TCP PF03634.13 CDI87632.1 - 2.6 8.6 14.7 3.2 8.3 14.7 1.1 1 0 0 1 1 1 0 TCP family transcription factor GREB1 PF15782.5 CDI87632.1 - 3.5 4.6 8.2 3.4 4.6 8.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Spt20 PF12090.8 CDI87632.1 - 4 7.0 26.7 5.2 6.6 26.7 1.1 1 0 0 1 1 1 0 Spt20 family DUF3138 PF11336.8 CDI87632.1 - 5 5.6 8.4 5.4 5.5 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Sox_N PF12444.8 CDI87632.1 - 7.3 7.8 13.4 14 6.9 13.4 1.4 1 0 0 1 1 1 0 Sox developmental protein N terminal CDC45 PF02724.14 CDI87632.1 - 7.5 4.7 10.2 9.2 4.4 10.2 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3464 PF11947.8 CDI87632.1 - 8.3 6.1 8.6 11 5.7 8.6 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 UPF0560 PF10577.9 CDI87632.1 - 8.4 4.7 13.2 9.5 4.6 13.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Hid1 PF12722.7 CDI87632.1 - 8.6 4.3 13.2 9.6 4.2 13.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CathepsinC_exc PF08773.11 CDI87633.1 - 0.0046 17.2 0.0 0.0087 16.3 0.0 1.5 1 0 0 1 1 1 1 Cathepsin C exclusion domain Suf PF05843.14 CDI87634.1 - 0.0037 17.3 17.4 0.0048 16.9 17.4 1.2 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Nop14 PF04147.12 CDI87634.1 - 0.0037 15.6 23.6 0.0045 15.3 23.6 1.0 1 0 0 1 1 1 1 Nop14-like family LAP1C PF05609.12 CDI87634.1 - 0.095 11.8 20.5 0.1 11.7 20.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Mitofilin PF09731.9 CDI87634.1 - 0.11 11.3 21.8 0.13 11.1 21.8 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein GREB1 PF15782.5 CDI87634.1 - 0.13 9.4 18.4 0.14 9.3 18.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SMYLE_N PF18615.1 CDI87634.1 - 0.18 11.3 16.6 0.25 10.9 16.6 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain PAT1 PF09770.9 CDI87634.1 - 0.22 9.8 18.9 0.26 9.5 18.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Macoilin PF09726.9 CDI87634.1 - 0.33 9.5 13.8 0.34 9.4 13.8 1.1 1 0 0 1 1 1 0 Macoilin family Lin-8 PF03353.15 CDI87634.1 - 0.33 10.5 18.8 0.41 10.2 18.8 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Hamartin PF04388.12 CDI87634.1 - 0.39 9.3 16.7 0.41 9.2 16.7 1.0 1 0 0 1 1 1 0 Hamartin protein DUF1387 PF07139.11 CDI87634.1 - 0.72 9.5 25.5 0.92 9.2 25.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) SDA1 PF05285.12 CDI87634.1 - 1.3 8.4 29.4 1.7 8.0 29.4 1.1 1 0 0 1 1 1 0 SDA1 Roughex PF06020.11 CDI87634.1 - 1.5 7.8 20.6 2.3 7.3 20.6 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Ndc1_Nup PF09531.10 CDI87634.1 - 1.5 7.4 15.7 1.8 7.2 15.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4551 PF15087.6 CDI87634.1 - 2.2 7.0 18.1 2.5 6.8 18.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Raftlin PF15250.6 CDI87634.1 - 3 6.5 17.0 3.6 6.2 17.0 1.2 1 0 0 1 1 1 0 Raftlin Peroxin-3 PF04882.12 CDI87634.1 - 4.4 6.2 19.7 6.3 5.7 19.7 1.4 1 0 0 1 1 1 0 Peroxin-3 SOG2 PF10428.9 CDI87634.1 - 6.1 5.9 19.0 7 5.7 19.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Pex14_N PF04695.13 CDI87634.1 - 6.6 7.4 30.8 1 10.0 26.0 1.8 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF5427 PF10310.9 CDI87634.1 - 7.3 5.4 28.5 11 4.8 28.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) MAJIN PF15077.6 CDI87635.1 - 3 7.6 15.9 3.4 7.4 15.9 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein MAP17 PF15807.5 CDI87635.1 - 6.5 7.0 9.4 9.4 6.5 9.3 1.4 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SR-25 PF10500.9 CDI87636.1 - 6.3e-06 26.0 25.5 6.3e-06 26.0 25.5 2.9 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein Di19_C PF14571.6 CDI87636.1 - 0.058 13.9 0.4 0.058 13.9 0.4 3.4 2 1 0 2 2 2 0 Stress-induced protein Di19, C-terminal DUF2339 PF10101.9 CDI87636.1 - 0.067 11.8 38.3 0.11 11.1 38.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) TPR_19 PF14559.6 CDI87637.1 - 1.5e-05 25.4 9.2 0.0037 17.7 0.3 10.3 8 4 2 10 10 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 CDI87637.1 - 2.4e-05 24.1 39.4 4.3e-05 23.3 0.3 8.7 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDI87637.1 - 3.3e-05 23.8 1.2 0.019 15.1 0.1 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDI87637.1 - 0.00026 20.7 14.9 0.00067 19.4 0.1 6.1 7 0 0 7 7 6 1 Tetratricopeptide repeat DUF2722 PF10846.8 CDI87637.1 - 0.0011 18.1 5.6 0.0011 18.1 5.6 8.4 6 2 1 7 7 4 1 Protein of unknown function (DUF2722) TPR_16 PF13432.6 CDI87637.1 - 0.0034 18.0 0.5 0.0034 18.0 0.5 12.9 10 4 3 14 14 11 3 Tetratricopeptide repeat Zip PF02535.22 CDI87637.1 - 0.0039 16.5 7.9 0.0039 16.5 7.9 4.2 3 1 1 4 4 4 1 ZIP Zinc transporter TPR_12 PF13424.6 CDI87637.1 - 0.022 15.1 1.8 0.022 15.1 1.8 8.9 9 1 1 10 10 8 0 Tetratricopeptide repeat Phostensin_N PF13916.6 CDI87637.1 - 0.048 14.0 0.2 0.048 14.0 0.2 9.1 6 2 2 9 9 4 0 PP1-regulatory protein, Phostensin N-terminal DUF572 PF04502.13 CDI87637.1 - 0.24 11.0 48.2 0.55 9.8 12.6 4.1 4 0 0 4 4 4 0 Family of unknown function (DUF572) TPR_6 PF13174.6 CDI87637.1 - 0.25 12.0 30.4 2.4 9.0 0.7 8.9 8 0 0 8 8 8 0 Tetratricopeptide repeat Asparaginase PF00710.20 CDI87638.1 - 3.9e-07 29.8 4.4 2.4e-06 27.2 0.0 3.3 3 0 0 3 3 3 1 Asparaginase, N-terminal Sin_N PF04801.13 CDI87638.1 - 0.00014 21.3 19.3 0.00014 21.3 19.3 2.0 1 1 1 2 2 2 1 Sin-like protein conserved region Spt20 PF12090.8 CDI87638.1 - 0.00029 20.5 65.7 0.031 13.9 16.7 3.3 3 0 0 3 3 3 2 Spt20 family DUF2722 PF10846.8 CDI87638.1 - 0.00084 18.4 18.3 0.00084 18.4 18.3 3.3 2 1 0 3 3 3 1 Protein of unknown function (DUF2722) Ribosomal_60s PF00428.19 CDI87638.1 - 0.029 15.0 11.4 0.029 15.0 11.4 3.8 4 0 0 4 4 4 0 60s Acidic ribosomal protein TT_ORF1 PF02956.14 CDI87638.1 - 0.64 8.6 12.9 2.3 6.8 6.2 2.1 2 0 0 2 2 2 0 TT viral orf 1 CNDH2_C PF16858.5 CDI87638.1 - 0.93 9.3 22.9 0.59 10.0 6.7 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term eIF-3_zeta PF05091.12 CDI87638.1 - 3.4 6.5 28.7 1.7 7.6 3.1 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ABC2_membrane_2 PF12679.7 CDI87638.1 - 6.2 6.0 10.7 6.3 6.0 1.4 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein Trypan_PARP PF05887.11 CDI87639.1 - 0.00035 20.5 1.8 0.003 17.5 0.8 2.3 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) Yip1 PF04893.17 CDI87639.1 - 0.091 12.5 0.3 2.7 7.7 0.8 2.1 1 1 1 2 2 2 0 Yip1 domain DUF3439 PF11921.8 CDI87639.1 - 0.73 9.8 4.4 2 8.4 4.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) CD20 PF04103.15 CDI87639.1 - 9.6 6.3 15.4 2.4 8.2 0.5 3.1 1 1 0 2 2 2 0 CD20-like family Kinesin PF00225.23 CDI87641.1 - 1e-19 70.7 0.1 1e-19 70.7 0.1 3.1 1 1 1 2 2 2 1 Kinesin motor domain PAT1 PF09770.9 CDI87641.1 - 0.0031 15.9 16.8 0.0031 15.9 16.8 1.7 2 0 0 2 2 2 1 Topoisomerase II-associated protein PAT1 Sin_N PF04801.13 CDI87641.1 - 2.3 7.3 23.1 6.2 5.9 23.1 1.6 1 0 0 1 1 1 0 Sin-like protein conserved region MecA PF05389.12 CDI87641.1 - 3.3 7.3 7.9 0.21 11.2 0.2 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF2828 PF11443.8 CDI87641.1 - 3.5 5.6 10.3 5 5.1 10.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF2052 PF09747.9 CDI87641.1 - 7.1 6.7 13.5 2.3 8.3 10.6 1.7 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) CLN3 PF02487.17 CDI87641.1 - 10 5.1 7.8 23 3.9 7.8 1.5 1 0 0 1 1 1 0 CLN3 protein Apolipoprotein PF01442.18 CDI87643.1 - 0.0049 16.8 1.5 0.0076 16.1 1.5 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain KxDL PF10241.9 CDI87643.1 - 0.024 14.9 0.2 7.1 7.0 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein SpoOE-like PF09388.10 CDI87643.1 - 0.079 12.9 3.0 7.4 6.6 0.4 2.4 2 0 0 2 2 2 0 Spo0E like sporulation regulatory protein DUF1043 PF06295.12 CDI87643.1 - 0.21 11.6 0.8 1.1 9.3 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) 5_3_exonuc PF01367.20 CDI87645.1 - 1e-08 35.6 0.0 1e-08 35.6 0.0 3.1 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold LRR_9 PF14580.6 CDI87646.1 - 7e-32 110.3 12.1 1.7e-31 109.0 11.7 2.0 1 1 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 CDI87646.1 - 8.4e-05 22.3 1.6 0.00023 20.8 1.6 1.7 1 1 0 1 1 1 1 Leucine rich repeat Velvet PF11754.8 CDI87646.1 - 0.0012 18.9 11.4 0.0014 18.6 11.4 1.2 1 0 0 1 1 1 1 Velvet factor LRR_4 PF12799.7 CDI87646.1 - 0.0013 19.1 6.6 0.0064 16.9 2.6 2.5 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) Smg8_Smg9 PF10220.9 CDI87646.1 - 0.0046 15.3 11.6 0.0055 15.1 11.6 1.2 1 0 0 1 1 1 1 Smg8_Smg9 TFIIA PF03153.13 CDI87646.1 - 0.006 16.6 49.6 0.0083 16.2 49.6 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SAGA-Tad1 PF12767.7 CDI87646.1 - 0.0076 16.0 13.2 0.0095 15.7 13.2 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit Dicty_REP PF05086.12 CDI87646.1 - 0.0088 14.1 9.1 0.011 13.8 9.1 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein V_ATPase_I PF01496.19 CDI87646.1 - 0.014 13.4 14.4 0.015 13.2 14.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-3_zeta PF05091.12 CDI87646.1 - 0.014 14.4 21.9 0.018 14.0 21.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Endostatin PF06482.11 CDI87646.1 - 0.017 14.6 14.6 0.022 14.2 14.6 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin GREB1 PF15782.5 CDI87646.1 - 0.023 11.9 15.3 0.025 11.7 15.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Band_3_cyto PF07565.13 CDI87646.1 - 0.025 14.4 13.7 0.034 13.9 13.7 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MMR1 PF08505.10 CDI87646.1 - 0.035 14.4 24.4 0.05 13.9 24.4 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein ALMT PF11744.8 CDI87646.1 - 0.043 12.7 12.3 0.047 12.5 12.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter NPR3 PF03666.13 CDI87646.1 - 0.065 12.0 14.2 0.08 11.7 14.2 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SOBP PF15279.6 CDI87646.1 - 0.082 13.5 14.3 0.1 13.2 14.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Exonuc_VII_L PF02601.15 CDI87646.1 - 0.089 12.3 21.5 0.11 12.1 21.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit SLC12 PF03522.15 CDI87646.1 - 0.11 11.5 20.1 0.13 11.2 20.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI87646.1 - 0.12 10.7 32.6 0.13 10.5 32.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ndc1_Nup PF09531.10 CDI87646.1 - 0.17 10.5 15.8 0.2 10.3 15.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Lin-8 PF03353.15 CDI87646.1 - 0.17 11.4 23.5 0.27 10.8 23.5 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist LicD PF04991.13 CDI87646.1 - 0.22 11.6 4.6 0.31 11.1 4.6 1.2 1 0 0 1 1 1 0 LicD family HCO3_cotransp PF00955.21 CDI87646.1 - 0.23 10.2 5.4 0.28 10.0 5.4 1.1 1 0 0 1 1 1 0 HCO3- transporter family SID-1_RNA_chan PF13965.6 CDI87646.1 - 0.25 9.7 6.8 0.27 9.6 6.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Activator_LAG-3 PF11498.8 CDI87646.1 - 0.3 10.0 61.5 0.39 9.6 61.5 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SpoVR PF04293.13 CDI87646.1 - 0.38 9.4 13.9 0.5 9.0 13.9 1.2 1 0 0 1 1 1 0 SpoVR like protein Bul1_N PF04425.12 CDI87646.1 - 0.45 9.2 13.8 0.66 8.7 13.8 1.2 1 0 0 1 1 1 0 Bul1 N terminus DUF4638 PF15472.6 CDI87646.1 - 0.52 10.0 14.1 0.67 9.6 14.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Borrelia_P83 PF05262.11 CDI87646.1 - 0.53 8.7 25.7 0.7 8.3 25.7 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein MTBP_C PF14920.6 CDI87646.1 - 0.79 9.4 17.7 1.4 8.6 17.7 1.4 1 0 0 1 1 1 0 MDM2-binding Hid1 PF12722.7 CDI87646.1 - 1.2 7.1 19.4 1.5 6.9 19.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MDM10 PF12519.8 CDI87646.1 - 1.3 7.8 15.3 1.5 7.6 15.3 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Membralin PF09746.9 CDI87646.1 - 1.6 7.7 14.5 2 7.4 14.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein LMBR1 PF04791.16 CDI87646.1 - 1.6 7.5 13.1 2 7.2 13.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Cellulose_synt PF03552.14 CDI87646.1 - 2 6.8 7.9 2.4 6.5 7.9 1.1 1 0 0 1 1 1 0 Cellulose synthase Connexin PF00029.19 CDI87646.1 - 2.1 8.0 15.8 3.5 7.3 15.8 1.4 1 0 0 1 1 1 0 Connexin Peptidase_S64 PF08192.11 CDI87646.1 - 2.4 6.5 16.8 3.6 6.0 16.8 1.4 1 0 0 1 1 1 0 Peptidase family S64 Zip PF02535.22 CDI87646.1 - 2.7 7.1 10.9 3.9 6.6 10.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PA26 PF04636.13 CDI87646.1 - 3.1 6.6 17.2 4.7 6.0 17.2 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) VIR_N PF15912.5 CDI87646.1 - 3.7 7.1 17.8 7.7 6.0 17.8 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal DUF2981 PF11200.8 CDI87646.1 - 4.1 7.1 10.7 2.4 7.8 9.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2981) MAJIN PF15077.6 CDI87646.1 - 4.2 7.1 16.8 7.1 6.3 16.8 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein CLN3 PF02487.17 CDI87646.1 - 4.3 6.3 16.2 6.4 5.7 16.2 1.3 1 0 0 1 1 1 0 CLN3 protein PBP1_TM PF14812.6 CDI87646.1 - 4.8 7.6 10.4 8.9 6.8 10.4 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UPF0560 PF10577.9 CDI87646.1 - 4.9 5.5 27.7 6.2 5.2 27.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Draxin PF15550.6 CDI87646.1 - 5 6.9 16.3 6.4 6.6 16.3 1.1 1 0 0 1 1 1 0 Draxin Peroxin-3 PF04882.12 CDI87646.1 - 5.9 5.8 31.6 2 7.3 29.1 1.4 1 1 0 1 1 1 0 Peroxin-3 Otopetrin PF03189.13 CDI87646.1 - 6.2 5.5 10.8 7.5 5.2 10.8 1.2 1 0 0 1 1 1 0 Otopetrin PPL5 PF18168.1 CDI87646.1 - 7.5 5.8 16.1 13 5.0 16.1 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Glyco_transf_41 PF13844.6 CDI87646.1 - 7.6 4.8 11.6 10 4.4 11.6 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 SMYLE_N PF18615.1 CDI87646.1 - 8.1 5.9 20.7 11 5.4 20.7 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain CAF1 PF04857.20 CDI87646.1 - 9.1 5.3 14.3 13 4.9 14.3 1.4 1 0 0 1 1 1 0 CAF1 family ribonuclease DUF2722 PF10846.8 CDI87647.1 - 0.0042 16.1 9.9 0.0042 16.1 9.9 6.8 6 1 0 6 6 6 2 Protein of unknown function (DUF2722) O-antigen_lig PF13425.6 CDI87647.1 - 3.1 6.5 7.2 0.66 8.7 0.3 2.4 2 0 0 2 2 2 0 O-antigen ligase like membrane protein RNA_pol_3_Rpc31 PF11705.8 CDI87649.1 - 0.009 16.3 11.9 0.009 16.3 11.9 7.9 4 1 4 8 8 8 1 DNA-directed RNA polymerase III subunit Rpc31 ESM4 PF15952.5 CDI87649.1 - 0.01 16.3 1.2 0.01 16.3 1.2 8.3 4 3 0 5 5 5 1 Enhancer of split M4 family TFIIA PF03153.13 CDI87650.1 - 0.00053 20.1 33.5 0.00071 19.7 33.5 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI87650.1 - 0.00098 18.8 18.3 0.00098 18.8 18.3 3.0 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein Cwf_Cwc_15 PF04889.12 CDI87650.1 - 0.005 16.6 1.0 0.0081 15.9 1.0 1.4 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein eIF-3_zeta PF05091.12 CDI87650.1 - 0.18 10.7 5.2 0.25 10.3 5.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Myc_N PF01056.18 CDI87650.1 - 0.25 11.2 15.4 0.43 10.4 15.4 1.4 1 0 0 1 1 1 0 Myc amino-terminal region Utp14 PF04615.13 CDI87650.1 - 0.92 8.0 12.9 1.2 7.6 12.9 1.2 1 0 0 1 1 1 0 Utp14 protein Peptidase_S64 PF08192.11 CDI87650.1 - 1.3 7.4 10.8 1.6 7.2 10.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 RskA PF10099.9 CDI87650.1 - 6.9 6.9 50.7 1.8e+04 -13.8 50.6 3.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI87651.1 - 0.056 13.7 0.1 0.056 13.7 0.1 4.1 1 1 2 4 4 4 0 Anti-sigma-K factor rskA Radical_SAM PF04055.21 CDI87652.1 - 0.042 14.2 0.6 0.51 10.7 0.0 2.4 3 0 0 3 3 3 0 Radical SAM superfamily MAS20 PF02064.15 CDI87653.1 - 0.013 15.6 2.7 0.013 15.6 2.7 3.0 2 1 0 2 2 1 0 MAS20 protein import receptor Connexin PF00029.19 CDI87653.1 - 0.031 14.1 21.4 0.26 11.0 14.1 2.1 2 0 0 2 2 2 0 Connexin LAP1C PF05609.12 CDI87653.1 - 0.035 13.2 38.7 0.043 12.9 38.7 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SR-25 PF10500.9 CDI87653.1 - 0.08 12.5 34.9 0.12 11.9 34.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PBP1_TM PF14812.6 CDI87653.1 - 0.15 12.4 12.4 0.38 11.1 5.2 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AAA_23 PF13476.6 CDI87653.1 - 0.62 10.5 42.2 0.39 11.2 4.1 2.3 2 0 0 2 2 2 0 AAA domain GAGA_bind PF06217.12 CDI87653.1 - 1.3 9.3 31.7 1.7 8.8 31.7 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4746 PF15928.5 CDI87653.1 - 2.2 7.7 26.8 0.6 9.5 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Noggin PF05806.12 CDI87653.1 - 3.9 7.3 18.9 5.2 6.9 12.3 2.1 2 0 0 2 2 2 0 Noggin DUF2126 PF09899.9 CDI87653.1 - 5.4 4.9 25.4 1.2 7.2 14.6 2.0 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) FAM176 PF14851.6 CDI87653.1 - 6.8 6.3 22.5 7.9 6.1 13.3 2.4 2 0 0 2 2 2 0 FAM176 family HMG14_17 PF01101.18 CDI87653.1 - 9.2 7.3 26.0 11 7.1 2.4 2.3 2 0 0 2 2 2 0 HMG14 and HMG17 SAPS PF04499.15 CDI87653.1 - 9.9 4.8 27.8 15 4.3 27.8 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Metallothio_2 PF01439.18 CDI87655.1 - 0.18 12.7 3.8 0.45 11.4 3.8 1.6 1 0 0 1 1 1 0 Metallothionein ABC2_membrane_3 PF12698.7 CDI87655.1 - 2.6 7.1 3.2 2.8 7.0 3.2 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF572 PF04502.13 CDI87655.1 - 6 6.4 39.7 8.4 5.9 39.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) AgI_II_C2 PF17998.1 CDI87657.1 - 0.087 13.1 2.4 0.13 12.6 1.4 1.7 1 1 1 2 2 2 0 Cell surface antigen I/II C2 terminal domain CENP-Q PF13094.6 CDI87657.1 - 0.26 11.5 5.8 0.32 11.2 5.8 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit NYD-SP28 PF14772.6 CDI87657.1 - 0.64 10.1 9.2 0.099 12.7 3.7 2.3 2 1 1 3 3 3 0 Sperm tail UPF0242 PF06785.11 CDI87657.1 - 1.1 9.3 6.7 1.7 8.7 6.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus SARAF PF06682.12 CDI87658.1 - 0.00051 19.8 7.5 0.00055 19.7 7.5 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis TRAP_alpha PF03896.16 CDI87658.1 - 0.0053 16.0 4.8 0.0055 15.9 4.8 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit MAP17 PF15807.5 CDI87658.1 - 0.0085 16.3 3.2 0.01 16.0 3.2 1.2 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 FAM176 PF14851.6 CDI87658.1 - 0.025 14.2 5.1 0.033 13.8 5.1 1.3 1 0 0 1 1 1 0 FAM176 family Connexin PF00029.19 CDI87658.1 - 0.053 13.3 8.1 0.063 13.0 8.1 1.2 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 CDI87658.1 - 0.069 11.1 13.6 0.07 11.0 13.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SID-1_RNA_chan PF13965.6 CDI87658.1 - 0.12 10.7 3.6 0.13 10.7 3.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Presenilin PF01080.17 CDI87658.1 - 0.13 11.0 15.2 0.13 11.0 15.2 1.1 1 0 0 1 1 1 0 Presenilin NicO PF03824.16 CDI87658.1 - 0.15 11.4 3.4 0.17 11.2 3.4 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein DUF2828 PF11443.8 CDI87658.1 - 0.15 10.1 11.4 0.15 10.1 11.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Calc_CGRP_IAPP PF00214.19 CDI87658.1 - 0.15 12.4 6.5 0.16 12.3 6.5 1.0 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family CLN3 PF02487.17 CDI87658.1 - 0.15 11.0 9.1 0.15 11.0 9.1 1.0 1 0 0 1 1 1 0 CLN3 protein CSG2 PF16965.5 CDI87658.1 - 0.16 10.9 7.4 0.18 10.7 7.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Serinc PF03348.15 CDI87658.1 - 0.19 10.6 5.4 0.18 10.7 5.4 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF1980 PF09323.10 CDI87658.1 - 0.19 11.6 6.1 0.2 11.5 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) PIP5K PF01504.18 CDI87658.1 - 0.22 10.7 9.0 0.21 10.8 9.0 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase OAD_gamma PF04277.13 CDI87658.1 - 0.23 12.1 1.0 0.83 10.3 1.0 1.8 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF1180 PF06679.12 CDI87658.1 - 0.25 11.7 5.0 0.28 11.6 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Sec62 PF03839.16 CDI87658.1 - 0.26 10.8 7.9 0.28 10.7 7.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 T2SSC PF11356.8 CDI87658.1 - 0.26 11.2 10.0 0.31 10.9 10.0 1.2 1 0 0 1 1 1 0 Type II secretion system protein C DUF4834 PF16118.5 CDI87658.1 - 0.27 12.2 17.7 0.67 10.9 17.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Kei1 PF08552.11 CDI87658.1 - 0.29 11.0 7.2 0.34 10.8 7.2 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Gastrin PF00918.17 CDI87658.1 - 0.3 12.1 9.9 0.3 12.1 9.9 1.1 1 0 0 1 1 1 0 Gastrin/cholecystokinin family G0-G1_switch_2 PF15103.6 CDI87658.1 - 0.33 11.4 7.2 0.38 11.2 7.2 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 CCDC53 PF10152.9 CDI87658.1 - 0.33 11.3 13.8 0.36 11.2 13.8 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex O-antigen_lig PF13425.6 CDI87658.1 - 0.37 9.5 2.9 0.38 9.5 2.9 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Peptidase_S49_N PF08496.10 CDI87658.1 - 0.46 10.5 8.5 0.49 10.5 8.5 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CBP_BcsG PF11658.8 CDI87658.1 - 0.53 8.6 9.9 0.54 8.6 9.9 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Peroxin-13_N PF04088.13 CDI87658.1 - 0.55 10.5 4.8 0.63 10.3 4.8 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Zip PF02535.22 CDI87658.1 - 0.74 9.0 10.2 0.71 9.0 10.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4446 PF14584.6 CDI87658.1 - 0.87 9.6 4.2 0.94 9.5 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Ctr PF04145.15 CDI87658.1 - 0.92 10.1 5.7 1 10.0 5.7 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Gti1_Pac2 PF09729.9 CDI87658.1 - 0.99 9.5 12.7 1 9.4 12.7 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family Folate_carrier PF01770.18 CDI87658.1 - 1 8.0 5.1 0.95 8.1 5.1 1.1 1 0 0 1 1 1 0 Reduced folate carrier SpoIIP PF07454.11 CDI87658.1 - 1.2 8.6 16.3 1.2 8.5 16.3 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PTPRCAP PF15713.5 CDI87658.1 - 1.2 9.5 18.1 1.2 9.4 18.1 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated R_equi_Vir PF05526.11 CDI87658.1 - 1.6 8.6 5.9 1.6 8.6 5.9 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF3408 PF11888.8 CDI87658.1 - 1.6 8.9 16.6 1.7 8.8 16.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) OATP PF03137.20 CDI87658.1 - 1.8 6.8 6.9 1.5 7.0 6.9 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Neur_chan_memb PF02932.16 CDI87658.1 - 1.8 8.6 11.3 1.8 8.6 11.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF913 PF06025.12 CDI87658.1 - 1.9 7.4 10.1 2 7.3 10.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) MAPEG PF01124.18 CDI87658.1 - 2 8.3 4.5 4 7.4 4.5 1.6 1 1 0 1 1 1 0 MAPEG family AIF_C PF14721.6 CDI87658.1 - 2.6 8.4 12.2 3 8.2 12.2 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term UPF0560 PF10577.9 CDI87658.1 - 2.8 6.3 22.6 2.7 6.4 22.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 FPN1 PF06963.12 CDI87658.1 - 3.8 6.0 5.1 4.2 5.8 5.1 1.2 1 0 0 1 1 1 0 Ferroportin1 (FPN1) CPSF100_C PF13299.6 CDI87658.1 - 4.2 7.5 14.0 4.6 7.4 14.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Otopetrin PF03189.13 CDI87658.1 - 5.6 5.7 8.7 5.5 5.7 8.7 1.1 1 0 0 1 1 1 0 Otopetrin CobT PF06213.12 CDI87658.1 - 5.7 6.2 25.8 6.3 6.1 25.8 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PepSY_TM PF03929.16 CDI87658.1 - 5.9 6.5 7.9 6.6 6.3 7.9 1.3 1 0 0 1 1 1 0 PepSY-associated TM region DUF5308 PF17233.2 CDI87658.1 - 6.1 7.1 18.9 6.8 6.9 18.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5308) SelP_N PF04592.14 CDI87658.1 - 6.2 6.2 26.4 6.9 6.0 26.4 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DDHD PF02862.17 CDI87658.1 - 7.5 6.6 14.6 8 6.6 14.6 1.1 1 0 0 1 1 1 0 DDHD domain PulA_N1 PF17999.1 CDI87659.1 - 0.023 15.4 1.6 0.023 15.4 1.6 1.4 1 1 0 1 1 1 0 Pullulanase N1-terminal domain GHMP_kinases_N PF00288.26 CDI87659.1 - 0.038 14.2 0.3 0.88 9.9 0.0 2.4 2 0 0 2 2 2 0 GHMP kinases N terminal domain GP38 PF05268.11 CDI87659.1 - 0.41 10.2 4.8 0.55 9.8 4.8 1.1 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 DUF874 PF05917.11 CDI87659.1 - 0.64 9.0 11.1 0.79 8.7 11.1 1.0 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) TMEM119 PF15724.5 CDI87659.1 - 4.2 7.3 10.1 5.8 6.9 10.1 1.2 1 0 0 1 1 1 0 TMEM119 family DUF4799 PF16056.5 CDI87659.1 - 7.3 5.6 9.0 12 5.0 7.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4799) CDC45 PF02724.14 CDI87659.1 - 7.9 4.6 14.1 8.9 4.5 14.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF5585 PF17823.1 CDI87660.1 - 1.8 7.4 25.0 2.1 7.2 25.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Ribosomal_60s PF00428.19 CDI87660.1 - 6.9 7.3 38.0 1.1 9.9 13.2 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein ketoacyl-synt PF00109.26 CDI87661.1 - 3.5e-149 495.3 0.6 1.4e-74 250.9 0.0 2.6 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CDI87661.1 - 2.4e-82 276.5 7.4 2e-43 148.7 1.0 2.3 2 0 0 2 2 2 2 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CDI87661.1 - 4.2e-80 265.5 0.4 1.5e-40 137.9 0.1 2.7 2 0 0 2 2 2 2 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 CDI87661.1 - 8.2e-51 173.4 0.1 1.6e-50 172.5 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 CDI87661.1 - 1.8e-30 106.2 0.2 4.9e-15 55.9 0.0 3.1 3 0 0 3 3 3 2 KR domain PP-binding PF00550.25 CDI87661.1 - 1.8e-28 98.7 0.0 3.3e-13 49.8 0.0 2.6 2 0 0 2 2 2 2 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CDI87661.1 - 2.1e-14 53.9 1.9 8.9e-06 26.1 0.0 3.3 4 0 0 4 4 2 2 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 CDI87661.1 - 1.9e-13 50.5 0.6 5.9e-13 48.9 0.1 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDI87661.1 - 9.7e-12 46.1 0.0 1.4e-10 42.3 0.0 2.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDI87661.1 - 3.6e-09 36.5 9.6 0.00013 21.8 0.0 4.5 5 0 0 5 5 5 2 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 CDI87661.1 - 3.7e-08 33.0 1.0 0.0058 16.0 0.0 2.4 2 0 0 2 2 2 2 Thiolase, N-terminal domain adh_short PF00106.25 CDI87661.1 - 0.00022 20.7 0.1 0.0016 17.9 0.0 2.5 3 0 0 3 3 3 1 short chain dehydrogenase Epimerase PF01370.21 CDI87661.1 - 0.013 15.0 0.0 0.026 14.0 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family AlaDh_PNT_C PF01262.21 CDI87661.1 - 0.046 13.0 0.4 0.1 11.9 0.4 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Polysacc_synt_2 PF02719.15 CDI87661.1 - 0.063 12.4 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein FabA PF07977.13 CDI87661.1 - 0.15 11.7 0.0 0.47 10.1 0.0 1.8 1 0 0 1 1 1 0 FabA-like domain ACP_syn_III PF08545.10 CDI87661.1 - 1.3 8.9 10.4 18 5.2 0.7 3.9 4 0 0 4 4 4 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III TraT PF05818.12 CDI87662.1 - 0.0068 16.1 5.9 0.0081 15.9 5.9 1.0 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein RskA PF10099.9 CDI87662.1 - 0.0092 16.3 25.2 0.011 16.0 25.2 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI87662.1 - 0.065 12.2 27.2 0.075 12.0 27.2 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 2HCT PF03390.15 CDI87662.1 - 0.094 11.3 3.9 0.11 11.1 3.9 1.0 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family Neuregulin PF02158.15 CDI87662.1 - 0.26 10.6 9.1 0.27 10.5 9.1 1.0 1 0 0 1 1 1 0 Neuregulin intracellular region eIF3_subunit PF08597.10 CDI87662.1 - 0.5 10.2 12.5 0.58 10.0 12.5 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Spt20 PF12090.8 CDI87662.1 - 0.54 9.8 20.6 0.56 9.8 20.6 1.1 1 0 0 1 1 1 0 Spt20 family DUF2232 PF09991.9 CDI87662.1 - 0.65 9.1 6.5 0.69 9.0 6.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) IHABP4_N PF16174.5 CDI87662.1 - 1.2 9.7 10.7 1.6 9.3 10.7 1.1 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal EIF4E-T PF10477.9 CDI87662.1 - 5.9 5.6 12.7 6 5.6 12.7 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Suf PF05843.14 CDI87662.1 - 6.3 6.7 12.3 6.2 6.7 12.3 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 CDI87662.1 - 6.3 6.7 30.2 7.3 6.5 30.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3676 PF12429.8 CDI87662.1 - 7.5 6.3 14.2 8.1 6.2 14.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3676) R_equi_Vir PF05526.11 CDI87662.1 - 9.5 6.0 9.9 11 5.8 9.9 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Helicase_C PF00271.31 CDI87664.1 - 1.5e-26 92.9 0.0 3e-26 91.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain GUCT PF08152.12 CDI87664.1 - 7.1e-09 35.8 0.0 5.3e-08 33.0 0.0 2.3 1 1 0 1 1 1 1 GUCT (NUC152) domain SUIM_assoc PF16619.5 CDI87664.1 - 0.065 13.3 6.1 0.056 13.5 0.6 3.0 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 ERCC3_RAD25_C PF16203.5 CDI87664.1 - 0.6 9.3 2.6 0.48 9.6 0.2 2.0 2 1 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase DUF4407 PF14362.6 CDI87665.1 - 0.015 14.7 17.4 0.017 14.5 17.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FAM60A PF15396.6 CDI87665.1 - 0.052 13.5 1.4 0.066 13.2 1.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Suf PF05843.14 CDI87665.1 - 0.089 12.8 4.1 0.1 12.6 4.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TraT PF05818.12 CDI87665.1 - 0.1 12.3 10.5 0.13 12.0 10.5 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein TFIIA PF03153.13 CDI87665.1 - 0.22 11.5 16.1 0.27 11.2 16.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tic110 PF16940.5 CDI87665.1 - 0.27 9.7 12.3 0.3 9.5 12.3 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter MIIP PF15734.5 CDI87665.1 - 0.34 10.4 7.7 0.39 10.2 7.7 1.0 1 0 0 1 1 1 0 Migration and invasion-inhibitory FAM199X PF15814.5 CDI87665.1 - 0.45 9.5 6.0 0.56 9.2 6.0 1.0 1 0 0 1 1 1 0 Protein family FAM199X Silic_transp PF03842.13 CDI87665.1 - 0.98 7.6 3.0 1.2 7.4 3.0 1.1 1 0 0 1 1 1 0 Silicon transporter cwf18 PF08315.12 CDI87665.1 - 1.9 9.1 11.1 2.8 8.6 11.1 1.2 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor MSP1_C PF07462.11 CDI87665.1 - 2.6 6.6 8.5 3 6.5 8.5 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Spt20 PF12090.8 CDI87665.1 - 2.7 7.5 12.2 3.9 7.0 12.2 1.3 1 0 0 1 1 1 0 Spt20 family BatD PF13584.6 CDI87665.1 - 3.8 6.2 10.4 0.51 9.1 0.6 2.1 2 0 0 2 2 2 0 Oxygen tolerance RskA PF10099.9 CDI87665.1 - 9.6 6.5 33.2 24 5.1 33.2 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA BAF1_ABF1 PF04684.13 CDI87666.1 - 3 6.8 8.2 2.9 6.8 8.2 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor GREB1 PF15782.5 CDI87667.1 - 4.5 4.3 36.4 4.9 4.1 36.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer zinc_ribbon_9 PF14369.6 CDI87669.1 - 7.1e-05 23.0 1.3 0.001 19.3 1.3 2.3 1 1 0 1 1 1 1 zinc-ribbon zf-C2HE PF16278.5 CDI87669.1 - 0.27 11.7 1.0 7.7 7.0 1.0 2.3 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger NPR3 PF03666.13 CDI87669.1 - 0.3 9.8 4.8 0.37 9.5 4.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Chromo PF00385.24 CDI87670.1 - 9.7e-15 54.2 0.0 1.4e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF1674 PF07896.12 CDI87671.1 - 1.3e-05 25.5 13.8 0.00017 22.0 13.8 2.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) RskA PF10099.9 CDI87671.1 - 5.7e-05 23.5 7.6 6.8e-05 23.2 7.6 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI87671.1 - 0.00042 20.0 27.1 0.00049 19.8 27.1 1.1 1 0 0 1 1 1 1 Spt20 family SR-25 PF10500.9 CDI87671.1 - 0.004 16.8 11.2 0.0049 16.5 11.2 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI87671.1 - 0.0097 15.9 23.8 0.011 15.8 23.8 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF3807 PF12720.7 CDI87671.1 - 0.021 15.1 16.0 0.023 15.0 16.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF4820 PF16091.5 CDI87671.1 - 0.03 13.7 12.4 0.036 13.4 12.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TCP PF03634.13 CDI87671.1 - 0.035 14.7 15.7 0.042 14.4 15.7 1.1 1 0 0 1 1 1 0 TCP family transcription factor BAF1_ABF1 PF04684.13 CDI87671.1 - 0.043 12.9 11.7 0.047 12.8 11.7 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Androgen_recep PF02166.16 CDI87671.1 - 0.049 12.5 21.3 0.057 12.3 21.3 1.1 1 0 0 1 1 1 0 Androgen receptor Med15 PF09606.10 CDI87671.1 - 0.059 12.0 18.0 0.058 12.1 18.0 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal eIF3_p135 PF12807.7 CDI87671.1 - 0.09 12.8 3.9 0.11 12.6 3.9 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 Pex14_N PF04695.13 CDI87671.1 - 0.12 13.0 15.7 0.13 12.9 15.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PA26 PF04636.13 CDI87671.1 - 0.12 11.2 9.7 0.13 11.1 9.7 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) RPN2_C PF18004.1 CDI87671.1 - 0.12 12.2 12.0 0.14 12.1 12.0 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DDHD PF02862.17 CDI87671.1 - 0.13 12.4 10.5 0.13 12.4 10.5 1.1 1 0 0 1 1 1 0 DDHD domain FHIPEP PF00771.20 CDI87671.1 - 0.16 10.4 4.9 0.17 10.3 4.9 1.1 1 0 0 1 1 1 0 FHIPEP family HA2 PF04408.23 CDI87671.1 - 0.16 12.2 4.6 0.22 11.8 4.6 1.3 1 0 0 1 1 1 0 Helicase associated domain (HA2) FYDLN_acid PF09538.10 CDI87671.1 - 0.19 12.4 8.1 0.25 12.1 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Med19 PF10278.9 CDI87671.1 - 0.27 11.2 10.1 0.34 10.8 10.1 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 SET PF00856.28 CDI87671.1 - 0.28 11.5 3.2 0.36 11.2 3.2 1.2 1 0 0 1 1 1 0 SET domain DUF4228 PF14009.6 CDI87671.1 - 0.32 11.4 8.6 0.34 11.3 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) PNISR PF15996.5 CDI87671.1 - 0.35 11.1 18.3 0.4 10.9 18.3 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR CbiD PF01888.17 CDI87671.1 - 0.35 10.1 2.8 0.44 9.8 2.8 1.1 1 0 0 1 1 1 0 CbiD DUF3408 PF11888.8 CDI87671.1 - 0.35 11.0 11.9 0.45 10.7 11.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Aminotran_1_2 PF00155.21 CDI87671.1 - 0.46 9.6 4.9 0.52 9.4 4.9 1.1 1 0 0 1 1 1 0 Aminotransferase class I and II SpoIIP PF07454.11 CDI87671.1 - 0.51 9.8 13.4 0.55 9.6 13.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) OATP PF03137.20 CDI87671.1 - 0.52 8.5 4.9 0.57 8.4 4.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Menin PF05053.13 CDI87671.1 - 0.52 8.6 9.1 0.56 8.5 9.1 1.0 1 0 0 1 1 1 0 Menin PAT1 PF09770.9 CDI87671.1 - 0.56 8.4 17.8 0.6 8.3 17.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ORC6 PF05460.13 CDI87671.1 - 0.61 9.3 12.7 0.69 9.1 12.7 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Chorion_2 PF03964.15 CDI87671.1 - 0.63 10.9 13.3 0.42 11.5 11.8 1.5 1 1 0 1 1 1 0 Chorion family 2 Spc7_N PF15402.6 CDI87671.1 - 0.77 7.9 16.3 0.92 7.7 16.3 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF2681 PF10883.8 CDI87671.1 - 0.8 10.1 19.8 1.2 9.6 19.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Connexin PF00029.19 CDI87671.1 - 0.85 9.3 9.1 0.98 9.1 9.1 1.1 1 0 0 1 1 1 0 Connexin DUF5568 PF17724.1 CDI87671.1 - 0.9 9.3 8.7 1.1 9.0 8.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5568) Serinc PF03348.15 CDI87671.1 - 0.92 8.4 7.5 1 8.2 7.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) PepSY_TM PF03929.16 CDI87671.1 - 1 8.9 4.8 1.1 8.9 4.8 1.1 1 0 0 1 1 1 0 PepSY-associated TM region DUF4746 PF15928.5 CDI87671.1 - 1 8.7 9.3 1.1 8.6 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Peptidase_S49_N PF08496.10 CDI87671.1 - 1.1 9.3 8.7 1.2 9.2 8.7 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PPP4R2 PF09184.11 CDI87671.1 - 1.1 8.8 11.3 1.3 8.6 11.3 1.1 1 0 0 1 1 1 0 PPP4R2 Spore_coat_CotO PF14153.6 CDI87671.1 - 1.2 9.0 18.7 1.4 8.8 18.7 1.1 1 0 0 1 1 1 0 Spore coat protein CotO CCDC53 PF10152.9 CDI87671.1 - 1.3 9.4 14.6 2.1 8.8 14.6 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Tim54 PF11711.8 CDI87671.1 - 1.3 7.7 12.6 1.5 7.6 12.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 GREB1 PF15782.5 CDI87671.1 - 1.4 6.0 12.0 1.4 6.0 12.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ndc1_Nup PF09531.10 CDI87671.1 - 1.5 7.5 10.3 1.5 7.4 10.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SprA-related PF12118.8 CDI87671.1 - 1.5 7.8 28.7 1.8 7.6 28.7 1.0 1 0 0 1 1 1 0 SprA-related family TERB2 PF15101.6 CDI87671.1 - 1.6 8.8 14.0 1.9 8.5 14.0 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CDC45 PF02724.14 CDI87671.1 - 1.6 6.9 11.6 1.6 6.9 11.6 1.0 1 0 0 1 1 1 0 CDC45-like protein eIF-3_zeta PF05091.12 CDI87671.1 - 1.7 7.6 16.4 1.9 7.4 16.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4834 PF16118.5 CDI87671.1 - 1.8 9.6 23.3 2.8 9.0 23.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) MMR1 PF08505.10 CDI87671.1 - 1.8 8.8 19.7 2.2 8.5 19.7 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Endostatin PF06482.11 CDI87671.1 - 1.9 7.9 12.5 2.1 7.7 12.5 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin tRNA_lig_CPD PF08302.11 CDI87671.1 - 2.2 7.6 12.7 2.9 7.3 12.7 1.1 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain R_equi_Vir PF05526.11 CDI87671.1 - 2.4 8.0 5.7 3.1 7.6 5.7 1.2 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein SLC12 PF03522.15 CDI87671.1 - 2.6 7.0 13.1 2.9 6.8 13.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI87671.1 - 2.6 8.0 9.7 2.9 7.9 9.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Roughex PF06020.11 CDI87671.1 - 2.7 7.0 13.2 3 6.8 13.2 1.2 1 0 0 1 1 1 0 Drosophila roughex protein RR_TM4-6 PF06459.12 CDI87671.1 - 2.8 7.7 15.8 3.4 7.4 15.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3537 PF12056.8 CDI87671.1 - 2.9 6.6 5.0 3.3 6.4 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) V_ATPase_I PF01496.19 CDI87671.1 - 2.9 5.7 13.5 3.9 5.3 13.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cellulose_synt PF03552.14 CDI87671.1 - 3 6.2 6.1 3.3 6.1 6.1 1.0 1 0 0 1 1 1 0 Cellulose synthase Paf1 PF03985.13 CDI87671.1 - 3.1 6.7 18.9 3.6 6.5 18.9 1.0 1 0 0 1 1 1 0 Paf1 PPL5 PF18168.1 CDI87671.1 - 3.2 7.0 10.1 3.6 6.8 10.1 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Presenilin PF01080.17 CDI87671.1 - 3.2 6.4 19.7 3.6 6.2 19.7 1.0 1 0 0 1 1 1 0 Presenilin MAJIN PF15077.6 CDI87671.1 - 3.5 7.4 9.4 3.7 7.3 9.4 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Ureide_permease PF07168.11 CDI87671.1 - 3.5 6.3 6.4 4.4 6.0 6.4 1.2 1 0 0 1 1 1 0 Ureide permease Sec62 PF03839.16 CDI87671.1 - 3.5 7.1 10.1 3.9 6.9 10.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 SMYLE_N PF18615.1 CDI87671.1 - 3.6 7.0 13.9 4.3 6.8 13.9 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain DUF4407 PF14362.6 CDI87671.1 - 3.6 6.8 14.2 4.1 6.7 14.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1980 PF09323.10 CDI87671.1 - 3.9 7.4 10.1 4.8 7.1 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) O-antigen_lig PF13425.6 CDI87671.1 - 4 6.1 3.8 4.3 6.0 3.8 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SAPS PF04499.15 CDI87671.1 - 4 6.1 11.2 4.2 6.0 11.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NARP1 PF12569.8 CDI87671.1 - 4.2 6.1 15.2 4.8 6.0 15.2 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Velvet PF11754.8 CDI87671.1 - 4.3 7.2 14.5 5 7.0 14.5 1.1 1 0 0 1 1 1 0 Velvet factor BNIP3 PF06553.12 CDI87671.1 - 4.5 6.9 12.2 5.2 6.7 12.2 1.1 1 0 0 1 1 1 0 BNIP3 THOC2_N PF16134.5 CDI87671.1 - 4.5 5.8 15.1 5.4 5.5 15.1 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus DUF913 PF06025.12 CDI87671.1 - 4.7 6.1 9.4 5.2 5.9 9.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SID-1_RNA_chan PF13965.6 CDI87671.1 - 5.2 5.4 6.9 5.5 5.3 6.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EIIBC-GUT_N PF03612.14 CDI87671.1 - 5.4 6.7 10.7 6.9 6.4 10.7 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus FlaG PF03646.15 CDI87671.1 - 5.8 7.1 21.0 0.63 10.2 16.9 1.5 2 0 0 2 2 1 0 FlaG protein CLN3 PF02487.17 CDI87671.1 - 6.2 5.7 8.6 6.8 5.6 8.6 1.1 1 0 0 1 1 1 0 CLN3 protein Suf PF05843.14 CDI87671.1 - 6.3 6.7 17.2 7.1 6.5 17.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) NST1 PF13945.6 CDI87671.1 - 6.6 6.8 21.1 0.63 10.1 16.5 1.6 2 0 0 2 2 1 0 Salt tolerance down-regulator XRN_M PF17846.1 CDI87671.1 - 6.7 5.6 10.5 7.2 5.4 10.5 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Hid1 PF12722.7 CDI87671.1 - 7.2 4.6 15.8 7.6 4.5 15.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CAML PF14963.6 CDI87671.1 - 7.3 6.6 8.0 8.1 6.5 8.0 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand FAM199X PF15814.5 CDI87671.1 - 7.6 5.5 10.4 9.6 5.2 10.4 1.1 1 0 0 1 1 1 0 Protein family FAM199X MDM10 PF12519.8 CDI87671.1 - 7.7 5.3 11.6 8 5.2 11.6 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Gti1_Pac2 PF09729.9 CDI87671.1 - 8.5 6.4 13.2 11 6.1 13.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Band_3_cyto PF07565.13 CDI87671.1 - 9 6.0 14.3 11 5.8 14.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain eIF3_subunit PF08597.10 CDI87671.1 - 9.5 6.0 21.0 12 5.8 21.0 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Membralin PF09746.9 CDI87671.1 - 9.9 5.1 7.4 10 5.0 7.4 1.0 1 0 0 1 1 1 0 Tumour-associated protein Thioredoxin PF00085.20 CDI87672.1 - 1.3e-05 25.1 0.1 2.2e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin FSA_C PF10479.9 CDI87672.1 - 1.4 6.9 4.4 1.6 6.8 4.4 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF3138 PF11336.8 CDI87672.1 - 6.5 5.2 9.4 7.1 5.1 9.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Tropomyosin_1 PF12718.7 CDI87674.1 - 0.0026 17.9 19.0 0.0033 17.6 19.0 1.2 1 0 0 1 1 1 1 Tropomyosin like SHE3 PF17078.5 CDI87674.1 - 0.0065 16.2 13.2 0.0075 16.0 13.2 1.0 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Ax_dynein_light PF10211.9 CDI87674.1 - 0.13 12.2 17.3 0.15 12.0 17.3 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain PHM7_cyt PF14703.6 CDI87674.1 - 0.19 11.9 6.5 0.25 11.6 6.5 1.2 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter KAsynt_C_assoc PF16197.5 CDI87674.1 - 0.33 11.4 3.7 0.48 10.9 3.7 1.3 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension RE_HaeIII PF09556.10 CDI87674.1 - 0.37 9.8 7.0 0.46 9.5 7.0 1.1 1 0 0 1 1 1 0 HaeIII restriction endonuclease Prominin PF05478.11 CDI87674.1 - 0.44 8.4 10.8 0.42 8.5 10.8 1.0 1 0 0 1 1 1 0 Prominin HAUS-augmin3 PF14932.6 CDI87674.1 - 0.56 9.7 21.4 0.65 9.5 21.4 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 V_ATPase_I PF01496.19 CDI87674.1 - 0.62 7.9 8.6 0.65 7.8 8.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PIN_8 PF18476.1 CDI87674.1 - 0.84 9.4 11.4 1 9.2 11.4 1.1 1 0 0 1 1 1 0 PIN like domain MAT1 PF06391.13 CDI87674.1 - 0.96 9.2 18.9 1.2 8.9 18.9 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF724 PF05266.14 CDI87674.1 - 2 8.2 14.6 2.6 7.8 14.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Mgr1 PF08602.10 CDI87674.1 - 2.4 6.9 7.7 2.8 6.7 7.7 1.0 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Fmp27_WPPW PF10359.9 CDI87674.1 - 3.8 6.3 12.3 4.5 6.0 12.3 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain TMPIT PF07851.13 CDI87674.1 - 4.8 6.3 11.5 5.5 6.1 11.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF778 PF05608.12 CDI87674.1 - 5.7 7.3 5.9 6.6 7.1 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF778) 5_nucleotid PF05761.14 CDI87674.1 - 9 5.1 9.6 9.8 5.0 9.6 1.1 1 0 0 1 1 1 0 5' nucleotidase family DUF16 PF01519.16 CDI87674.1 - 9.9 6.7 16.1 22 5.6 15.6 1.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 SR-25 PF10500.9 CDI87676.1 - 0.0012 18.5 7.1 0.0012 18.5 7.1 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CCDC106 PF15794.5 CDI87676.1 - 0.013 15.3 2.0 0.014 15.1 2.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF3446 PF11928.8 CDI87676.1 - 0.028 14.7 8.0 0.043 14.1 8.0 1.3 1 0 0 1 1 1 0 Early growth response N-terminal domain TUSC2 PF15000.6 CDI87678.1 - 0.19 12.0 0.8 0.42 10.9 0.8 1.5 1 0 0 1 1 1 0 Tumour suppressor candidate 2 Spt20 PF12090.8 CDI87678.1 - 0.93 9.1 11.9 1.7 8.2 11.9 1.3 1 0 0 1 1 1 0 Spt20 family DUF1180 PF06679.12 CDI87681.1 - 0.0049 17.3 6.4 0.0071 16.8 6.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) TRAP_alpha PF03896.16 CDI87681.1 - 0.0062 15.8 6.7 0.0085 15.3 6.7 1.2 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Zip PF02535.22 CDI87681.1 - 0.007 15.6 15.5 0.008 15.4 15.5 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter CLN3 PF02487.17 CDI87681.1 - 0.018 14.1 14.0 0.022 13.9 14.0 1.1 1 0 0 1 1 1 0 CLN3 protein DUF2828 PF11443.8 CDI87681.1 - 0.021 13.0 20.3 0.025 12.7 20.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Serinc PF03348.15 CDI87681.1 - 0.03 13.3 6.0 0.039 12.9 6.0 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) ALMT PF11744.8 CDI87681.1 - 0.038 12.8 16.2 0.041 12.7 16.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM60A PF15396.6 CDI87681.1 - 0.04 13.9 19.0 0.052 13.6 19.0 1.0 1 0 0 1 1 1 0 Protein Family FAM60A SID-1_RNA_chan PF13965.6 CDI87681.1 - 0.043 12.2 7.1 0.045 12.2 7.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NicO PF03824.16 CDI87681.1 - 0.044 13.1 10.7 0.065 12.6 10.7 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein Velvet PF11754.8 CDI87681.1 - 0.052 13.5 20.0 0.062 13.2 20.0 1.0 1 0 0 1 1 1 0 Velvet factor CSG2 PF16965.5 CDI87681.1 - 0.055 12.4 9.2 0.065 12.2 9.2 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Endostatin PF06482.11 CDI87681.1 - 0.059 12.8 20.6 0.065 12.7 20.6 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SARAF PF06682.12 CDI87681.1 - 0.08 12.6 15.2 0.091 12.4 15.2 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis V_ATPase_I PF01496.19 CDI87681.1 - 0.091 10.7 25.9 0.11 10.4 25.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CBP_BcsG PF11658.8 CDI87681.1 - 0.11 10.9 14.4 0.13 10.6 14.4 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Peptidase_S49_N PF08496.10 CDI87681.1 - 0.12 12.5 19.2 0.18 11.9 19.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4746 PF15928.5 CDI87681.1 - 0.12 11.7 13.2 0.14 11.5 13.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) BORG_CEP PF14957.6 CDI87681.1 - 0.16 13.1 12.7 0.19 12.9 12.7 1.1 1 0 0 1 1 1 0 Cdc42 effector Presenilin PF01080.17 CDI87681.1 - 0.23 10.2 27.3 0.29 9.8 27.3 1.1 1 0 0 1 1 1 0 Presenilin Ni_hydr_CYTB PF01292.20 CDI87681.1 - 0.24 11.0 1.0 0.6 9.7 1.0 1.7 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 ETRAMP PF09716.10 CDI87681.1 - 0.25 11.4 0.9 0.77 9.9 0.9 1.9 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) CRA PF06589.11 CDI87681.1 - 0.26 11.4 4.2 0.61 10.2 4.3 1.5 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) O-antigen_lig PF13425.6 CDI87681.1 - 0.28 9.9 6.6 0.36 9.6 6.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Spore_coat_CotO PF14153.6 CDI87681.1 - 0.32 10.9 25.5 0.41 10.6 25.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Tim54 PF11711.8 CDI87681.1 - 0.38 9.5 15.7 0.45 9.2 15.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4569 PF15133.6 CDI87681.1 - 0.42 10.3 24.4 0.49 10.1 24.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) DUF4638 PF15472.6 CDI87681.1 - 0.51 10.0 18.0 0.62 9.8 18.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) HCO3_cotransp PF00955.21 CDI87681.1 - 0.54 9.0 9.1 0.57 8.9 9.1 1.1 1 0 0 1 1 1 0 HCO3- transporter family SLC12 PF03522.15 CDI87681.1 - 0.56 9.2 24.0 0.67 8.9 24.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF2126 PF09899.9 CDI87681.1 - 0.65 8.0 15.6 0.89 7.5 15.6 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) ExbD PF02472.16 CDI87681.1 - 0.73 10.0 10.2 0.97 9.6 10.2 1.2 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR DDHD PF02862.17 CDI87681.1 - 0.8 9.8 18.0 1.3 9.1 18.0 1.3 1 0 0 1 1 1 0 DDHD domain Sec62 PF03839.16 CDI87681.1 - 0.83 9.1 17.4 1.1 8.7 17.4 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Membralin PF09746.9 CDI87681.1 - 0.84 8.6 13.8 1 8.4 13.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein NPR3 PF03666.13 CDI87681.1 - 0.86 8.3 20.1 1 8.1 20.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2370 PF10176.9 CDI87681.1 - 0.95 9.1 9.4 1.2 8.7 9.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) NARP1 PF12569.8 CDI87681.1 - 0.95 8.3 21.2 1.1 8.1 21.2 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DAG_kinase_N PF14513.6 CDI87681.1 - 1 9.5 21.6 1.3 9.2 21.6 1.1 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Peroxin-13_N PF04088.13 CDI87681.1 - 1.2 9.4 15.5 2e+02 2.2 15.5 2.0 1 1 0 1 1 1 0 Peroxin 13, N-terminal region SKA1 PF07160.12 CDI87681.1 - 1.3 8.9 25.1 1.4 8.7 25.1 1.0 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF3357 PF11837.8 CDI87681.1 - 1.3 9.5 11.2 32 5.0 8.1 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) Mem_trans PF03547.18 CDI87681.1 - 1.5 7.2 6.8 1.8 6.9 6.8 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF3112 PF11309.8 CDI87681.1 - 1.7 8.0 4.8 2.5 7.5 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Ndc1_Nup PF09531.10 CDI87681.1 - 3.3 6.3 16.0 4.4 5.9 16.0 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup LAP1C PF05609.12 CDI87681.1 - 3.4 6.6 26.5 4 6.4 26.5 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Gti1_Pac2 PF09729.9 CDI87681.1 - 3.7 7.6 20.0 5.6 7.0 20.0 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family GRP PF07172.11 CDI87681.1 - 4.1 8.2 15.6 60 4.4 15.6 2.1 1 1 0 1 1 1 0 Glycine rich protein family RP-C_C PF11800.8 CDI87681.1 - 4.8 7.2 19.9 6.6 6.8 19.9 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region BPL_N PF09825.9 CDI87681.1 - 4.9 6.1 16.5 5.8 5.9 16.5 1.0 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Otopetrin PF03189.13 CDI87681.1 - 5.1 5.8 16.5 6.3 5.5 16.5 1.2 1 0 0 1 1 1 0 Otopetrin Rtf2 PF04641.12 CDI87681.1 - 5.3 6.3 19.2 6.6 6.0 19.2 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Conotoxin PF02950.17 CDI87681.1 - 5.8 8.0 28.3 1.8e+04 -7.0 28.3 2.3 1 1 0 1 1 0 0 Conotoxin AF-4 PF05110.13 CDI87681.1 - 6.2 4.8 32.6 7 4.6 32.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein HemX PF04375.14 CDI87681.1 - 6.7 5.9 49.6 8 5.6 49.6 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase AUX_IAA PF02309.16 CDI87681.1 - 7.4 6.3 16.9 8.8 6.1 16.9 1.0 1 0 0 1 1 1 0 AUX/IAA family DUF2052 PF09747.9 CDI87681.1 - 7.9 6.6 23.9 10 6.2 23.9 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RR_TM4-6 PF06459.12 CDI87681.1 - 8 6.2 25.9 9.9 5.9 25.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4446 PF14584.6 CDI87681.1 - 8.5 6.3 15.8 31 4.5 15.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) DUF4045 PF13254.6 CDI87681.1 - 8.9 5.8 20.8 11 5.5 20.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) BSP_II PF05432.11 CDI87683.1 - 0.96 9.1 19.9 1 9.0 19.9 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Nop53 PF07767.11 CDI87683.1 - 2.6 7.4 26.9 3.1 7.1 26.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RNA_pol_3_Rpc31 PF11705.8 CDI87683.1 - 2.6 8.2 22.0 3.5 7.8 22.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 FYDLN_acid PF09538.10 CDI87683.1 - 2.9 8.6 14.5 4 8.2 14.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) NOA36 PF06524.12 CDI87683.1 - 5.4 6.3 12.9 5.7 6.2 12.9 1.1 1 0 0 1 1 1 0 NOA36 protein CSRNP_N PF16019.5 CDI87683.1 - 6 6.7 16.0 6.5 6.6 16.0 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus ANAPC15 PF15243.6 CDI87683.1 - 6.9 7.2 25.5 5.5 7.5 24.7 1.3 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 15 DUF5352 PF17303.2 CDI87683.1 - 7 6.5 7.2 8.1 6.3 7.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5352) DUF2052 PF09747.9 CDI87683.1 - 7.4 6.6 23.3 8.4 6.5 23.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PNISR PF15996.5 CDI87684.1 - 0.041 14.1 8.7 0.056 13.7 8.7 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR TFIIA PF03153.13 CDI87684.1 - 0.064 13.3 24.2 0.095 12.7 24.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SARAF PF06682.12 CDI87684.1 - 0.12 12.0 9.5 0.15 11.7 9.5 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis NST1 PF13945.6 CDI87684.1 - 0.18 11.9 14.5 0.23 11.6 14.5 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator BAF1_ABF1 PF04684.13 CDI87684.1 - 0.21 10.6 10.5 0.25 10.4 10.5 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Senescence_reg PF04520.13 CDI87684.1 - 0.33 11.8 9.8 0.44 11.4 9.8 1.2 1 0 0 1 1 1 0 Senescence regulator MAT1 PF06391.13 CDI87684.1 - 0.54 10.1 11.3 0.68 9.7 11.3 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Plasmodium_Vir PF05795.11 CDI87684.1 - 0.61 9.4 4.3 0.74 9.2 4.3 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein ALMT PF11744.8 CDI87684.1 - 0.61 8.8 7.6 0.7 8.7 7.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 CDI87684.1 - 0.98 8.4 9.3 1.1 8.1 9.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 MMR1 PF08505.10 CDI87684.1 - 2 8.7 14.3 2.6 8.2 14.3 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Macoilin PF09726.9 CDI87684.1 - 2.1 6.8 12.7 2.4 6.6 12.7 1.0 1 0 0 1 1 1 0 Macoilin family CLN3 PF02487.17 CDI87684.1 - 2.2 7.2 5.5 2.8 6.9 5.5 1.2 1 0 0 1 1 1 0 CLN3 protein Ndc1_Nup PF09531.10 CDI87684.1 - 3.3 6.3 11.1 3.3 6.3 11.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RR_TM4-6 PF06459.12 CDI87684.1 - 3.4 7.4 10.5 4.2 7.1 10.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDK2AP PF09806.9 CDI87684.1 - 3.6 7.6 17.8 4.8 7.2 17.8 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Lin-8 PF03353.15 CDI87684.1 - 4.7 6.7 14.3 5.8 6.4 14.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 CDI87684.1 - 5 5.8 14.5 6.1 5.5 14.5 1.1 1 0 0 1 1 1 0 Presenilin PAP1 PF08601.10 CDI87684.1 - 6.3 6.4 14.3 7.8 6.1 14.3 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 GREB1 PF15782.5 CDI87684.1 - 8 3.4 16.0 9.2 3.2 16.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Senescence_reg PF04520.13 CDI87685.1 - 0.12 13.2 7.9 0.13 13.1 7.9 1.1 1 0 0 1 1 1 0 Senescence regulator SARAF PF06682.12 CDI87685.1 - 0.22 11.1 12.9 0.28 10.8 12.9 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis PTPRCAP PF15713.5 CDI87685.1 - 0.29 11.4 16.5 0.36 11.1 16.5 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated PRAS PF15798.5 CDI87685.1 - 0.36 11.4 5.8 0.47 11.0 5.8 1.1 1 0 0 1 1 1 0 Proline-rich AKT1 substrate 1 Scs3p PF10261.9 CDI87685.1 - 0.64 9.5 3.3 0.91 9.0 3.3 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF3474 PF11960.8 CDI87685.1 - 0.99 9.6 3.0 1 9.5 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3474) DUF4228 PF14009.6 CDI87685.1 - 1.1 9.6 10.1 1.2 9.5 10.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) CDC45 PF02724.14 CDI87685.1 - 1.5 7.0 15.0 1.7 6.8 15.0 1.0 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 CDI87685.1 - 1.6 8.5 17.5 1.9 8.3 17.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3381 PF11861.8 CDI87685.1 - 1.8 8.3 25.1 2.1 8.1 25.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Tim54 PF11711.8 CDI87685.1 - 1.9 7.2 13.6 2.4 6.9 13.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF3987 PF13148.6 CDI87685.1 - 2.1 7.3 10.2 2.6 7.0 10.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Presenilin PF01080.17 CDI87685.1 - 2.1 7.0 18.4 2.5 6.8 18.4 1.0 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI87685.1 - 2.2 7.2 17.2 2.5 7.0 17.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 HGTP_anticodon2 PF12745.7 CDI87685.1 - 2.3 7.7 19.4 2.7 7.4 19.4 1.0 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Gti1_Pac2 PF09729.9 CDI87685.1 - 2.4 8.2 13.7 3.3 7.8 13.7 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family ALMT PF11744.8 CDI87685.1 - 2.5 6.8 14.3 2.8 6.7 14.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Membralin PF09746.9 CDI87685.1 - 3.4 6.6 10.7 3.8 6.5 10.7 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF1892 PF08987.10 CDI87685.1 - 3.5 7.9 9.7 11 6.3 4.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1892) Rtf2 PF04641.12 CDI87685.1 - 3.6 6.9 18.1 4.5 6.6 18.1 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Hid1 PF12722.7 CDI87685.1 - 4.5 5.3 13.3 4.9 5.2 13.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4698 PF15769.5 CDI87685.1 - 5.7 5.9 20.4 6.5 5.7 20.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) DUF2828 PF11443.8 CDI87685.1 - 5.9 4.9 18.0 7 4.6 18.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CLN3 PF02487.17 CDI87685.1 - 7 5.6 12.7 7.7 5.4 12.7 1.1 1 0 0 1 1 1 0 CLN3 protein Sec62 PF03839.16 CDI87685.1 - 7.2 6.1 17.8 8.8 5.8 17.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 UPF0565 PF10561.9 CDI87685.1 - 8.7 5.4 12.3 10 5.2 12.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 TFIIA PF03153.13 CDI87685.1 - 9 6.2 36.1 12 5.8 36.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MDM10 PF12519.8 CDI87685.1 - 9.2 5.0 14.8 11 4.7 14.8 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Med15 PF09606.10 CDI87686.1 - 0.59 8.8 19.8 0.55 8.8 19.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Phostensin_N PF13916.6 CDI87686.1 - 8.3 6.8 11.5 17 5.9 0.1 2.3 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal RPN1_C PF18051.1 CDI87687.1 - 4.3e-16 58.7 0.0 7.4e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal AXIN1_TNKS_BD PF16646.5 CDI87688.1 - 0.041 14.8 4.7 0.055 14.4 4.7 1.2 1 0 0 1 1 1 0 Axin-1 tankyrase binding domain Prothymosin PF03247.14 CDI87688.1 - 0.48 10.9 13.4 0.52 10.8 13.4 1.1 1 0 0 1 1 1 0 Prothymosin/parathymosin family DUF1864 PF08933.11 CDI87688.1 - 0.6 8.8 8.7 0.6 8.8 8.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1864) LRR19-TM PF15176.6 CDI87688.1 - 2.8 8.0 6.2 3.5 7.7 6.2 1.2 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF5327 PF17261.2 CDI87688.1 - 8.2 7.2 23.7 9.8 7.0 23.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5327) Sugar_tr PF00083.24 CDI87689.1 - 2.1 7.1 12.7 2.4 6.9 12.7 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter Presenilin PF01080.17 CDI87689.1 - 4.9 5.8 44.6 4.8 5.8 44.6 1.0 1 0 0 1 1 1 0 Presenilin DUF3807 PF12720.7 CDI87689.1 - 6.6 7.0 43.5 8.5 6.6 43.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) NPR3 PF03666.13 CDI87689.1 - 6.7 5.4 36.0 7.6 5.2 36.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 OpcA_G6PD_assem PF10128.9 CDI87690.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.1 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase subunit SseC PF04888.12 CDI87692.1 - 0.045 13.4 24.5 0.046 13.3 24.5 1.0 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Spt20 PF12090.8 CDI87692.1 - 0.21 11.2 3.4 0.17 11.5 3.4 1.0 1 0 0 1 1 1 0 Spt20 family SUIM_assoc PF16619.5 CDI87692.1 - 0.52 10.4 7.8 0.65 10.1 7.8 1.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 SLATT_1 PF18181.1 CDI87692.1 - 0.75 9.7 13.4 1.1 9.2 13.4 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 TraT PF05818.12 CDI87692.1 - 1.2 8.8 13.0 1.4 8.5 13.0 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein FAM199X PF15814.5 CDI87692.1 - 1.7 7.6 3.5 2.1 7.3 3.5 1.1 1 0 0 1 1 1 0 Protein family FAM199X Mtc PF03820.17 CDI87692.1 - 2.6 7.0 12.2 3 6.8 12.2 1.0 1 0 0 1 1 1 0 Tricarboxylate carrier Tic110 PF16940.5 CDI87692.1 - 9.2 4.6 20.6 9.2 4.6 20.6 1.0 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF4813 PF16072.5 CDI87695.1 - 1.3 8.7 20.7 2.2 7.9 10.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4813) RskA PF10099.9 CDI87695.1 - 1.9 8.7 18.5 15 5.8 0.1 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI87696.1 - 0.017 15.4 18.1 0.019 15.3 18.1 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Neuregulin PF02158.15 CDI87696.1 - 0.27 10.5 10.0 0.32 10.3 10.0 1.0 1 0 0 1 1 1 0 Neuregulin intracellular region 2HCT PF03390.15 CDI87696.1 - 0.64 8.6 2.1 0.6 8.7 2.1 1.0 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family CbiD PF01888.17 CDI87696.1 - 0.79 9.0 6.9 0.88 8.8 6.9 1.1 1 0 0 1 1 1 0 CbiD DUF2992 PF11208.8 CDI87696.1 - 0.9 9.8 17.0 0.92 9.7 17.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Ribosomal_60s PF00428.19 CDI87696.1 - 1.5 9.5 12.3 2.3 8.9 12.3 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein eIF3_subunit PF08597.10 CDI87696.1 - 1.5 8.6 17.7 1.7 8.5 17.7 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Spt20 PF12090.8 CDI87696.1 - 2.8 7.5 25.9 3 7.4 25.9 1.1 1 0 0 1 1 1 0 Spt20 family AAA_23 PF13476.6 CDI87696.1 - 3.5 8.1 14.1 3.7 8.0 14.1 1.0 1 0 0 1 1 1 0 AAA domain DUF3464 PF11947.8 CDI87696.1 - 5.7 6.7 9.2 6.8 6.4 9.2 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Presenilin PF01080.17 CDI87696.1 - 6.9 5.3 10.4 6.5 5.4 10.4 1.0 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CDI87696.1 - 7 6.5 15.7 7.2 6.5 15.7 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TERB2 PF15101.6 CDI87696.1 - 7.8 6.5 14.3 8.2 6.4 14.3 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 R_equi_Vir PF05526.11 CDI87696.1 - 8.6 6.2 7.1 9.6 6.0 7.1 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF4407 PF14362.6 CDI87696.1 - 9.6 5.5 16.2 9.8 5.4 16.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IMP2_N PF18590.1 CDI87697.1 - 0.00084 19.8 0.0 0.0016 18.9 0.0 1.5 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain IMP2_C PF18591.1 CDI87697.1 - 0.0027 17.5 0.8 0.0041 17.0 0.8 1.2 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) C-terminal domain TFIIA PF03153.13 CDI87698.1 - 3.1 7.7 20.8 3.6 7.5 20.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PIP5K PF01504.18 CDI87699.1 - 0.033 13.4 15.3 0.032 13.4 15.3 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase PBP1_TM PF14812.6 CDI87699.1 - 0.044 14.1 3.5 0.048 14.0 3.5 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BBL5 PF07289.11 CDI87699.1 - 0.076 12.0 13.4 0.084 11.9 13.4 1.0 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein AIF_C PF14721.6 CDI87699.1 - 0.11 12.9 12.7 0.12 12.7 12.7 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Spt20 PF12090.8 CDI87699.1 - 0.15 11.6 45.8 0.19 11.3 45.8 1.2 1 0 0 1 1 1 0 Spt20 family SelP_N PF04592.14 CDI87699.1 - 0.41 10.0 25.8 0.44 9.9 25.8 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RPN2_C PF18004.1 CDI87699.1 - 0.42 10.5 16.2 0.48 10.3 16.2 1.0 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Connexin PF00029.19 CDI87699.1 - 0.47 10.2 16.3 0.5 10.1 16.3 1.0 1 0 0 1 1 1 0 Connexin DUF4834 PF16118.5 CDI87699.1 - 0.54 11.3 23.8 0.66 11.0 23.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EFTUD2 PF16004.5 CDI87699.1 - 0.55 10.8 17.9 0.63 10.6 17.9 1.1 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus FAM76 PF16046.5 CDI87699.1 - 0.67 9.3 22.4 0.77 9.1 22.4 1.0 1 0 0 1 1 1 0 FAM76 protein Afi1 PF07792.12 CDI87699.1 - 0.69 10.4 15.8 0.85 10.1 15.8 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking TFB6 PF17110.5 CDI87699.1 - 0.79 9.5 10.2 0.9 9.3 10.2 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH FYDLN_acid PF09538.10 CDI87699.1 - 0.85 10.3 11.6 1 10.0 11.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DcuA_DcuB PF03605.14 CDI87699.1 - 0.9 8.4 5.4 1.1 8.1 5.4 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Tim54 PF11711.8 CDI87699.1 - 0.92 8.2 16.5 0.98 8.1 16.5 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CPSF100_C PF13299.6 CDI87699.1 - 0.93 9.7 15.5 1 9.5 15.5 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RPA43_OB PF17875.1 CDI87699.1 - 0.94 10.1 11.6 1.1 9.8 11.6 1.1 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I NPR3 PF03666.13 CDI87699.1 - 1 8.1 16.2 0.99 8.1 16.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF1764 PF08576.10 CDI87699.1 - 1 10.3 15.0 1.3 10.0 15.0 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) RRP36 PF06102.12 CDI87699.1 - 1 9.3 21.3 1.1 9.2 21.3 1.0 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 RR_TM4-6 PF06459.12 CDI87699.1 - 1.1 9.0 19.8 1.2 8.9 19.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peroxin-13_N PF04088.13 CDI87699.1 - 1.1 9.5 8.7 1.6 9.0 8.7 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region EIIBC-GUT_N PF03612.14 CDI87699.1 - 1.4 8.7 16.2 1.9 8.2 16.2 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus SpoIIP PF07454.11 CDI87699.1 - 1.4 8.3 21.5 1.5 8.2 21.5 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) STAC2_u1 PF16664.5 CDI87699.1 - 1.5 9.3 15.0 1.6 9.2 15.0 1.0 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Gti1_Pac2 PF09729.9 CDI87699.1 - 1.5 8.9 16.1 1.7 8.7 16.1 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family Presenilin PF01080.17 CDI87699.1 - 1.5 7.5 22.3 1.6 7.4 22.3 1.0 1 0 0 1 1 1 0 Presenilin DUF4746 PF15928.5 CDI87699.1 - 1.5 8.1 13.4 1.7 8.0 13.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4770 PF15994.5 CDI87699.1 - 1.6 9.0 20.9 1.8 8.8 20.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) eIF-3_zeta PF05091.12 CDI87699.1 - 1.6 7.6 25.6 1.7 7.5 25.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EPL1 PF10513.9 CDI87699.1 - 1.6 9.1 22.9 1.8 8.9 22.9 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like CDC45 PF02724.14 CDI87699.1 - 1.6 6.9 15.1 1.8 6.8 15.1 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 CDI87699.1 - 1.6 8.4 13.4 1.9 8.1 13.4 1.0 1 0 0 1 1 1 0 FAM176 family V_ATPase_I PF01496.19 CDI87699.1 - 1.7 6.5 22.5 1.7 6.5 22.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Sec62 PF03839.16 CDI87699.1 - 1.7 8.1 16.3 1.8 8.0 16.3 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 SID-1_RNA_chan PF13965.6 CDI87699.1 - 1.8 6.9 11.8 1.9 6.8 11.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CCDC53 PF10152.9 CDI87699.1 - 1.8 9.0 18.5 2 8.9 18.5 1.0 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex CobT PF06213.12 CDI87699.1 - 2 7.7 24.4 2.4 7.5 24.4 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Zip PF02535.22 CDI87699.1 - 2.4 7.3 17.3 2.6 7.2 17.3 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter EOS1 PF12326.8 CDI87699.1 - 2.6 7.9 12.3 2.8 7.8 12.3 1.1 1 0 0 1 1 1 0 N-glycosylation protein DUF913 PF06025.12 CDI87699.1 - 2.9 6.8 13.1 3.3 6.6 13.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) MMU163 PF17119.5 CDI87699.1 - 2.9 7.0 9.7 3.2 6.8 9.7 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DUF2072 PF09845.9 CDI87699.1 - 3 8.1 14.7 3.3 8.0 14.7 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein DUF3464 PF11947.8 CDI87699.1 - 3.1 7.6 16.5 4.2 7.1 16.5 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Kei1 PF08552.11 CDI87699.1 - 3.3 7.6 12.7 3.4 7.5 12.7 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Endostatin PF06482.11 CDI87699.1 - 3.4 7.0 20.7 3.4 7.0 20.7 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin NST1 PF13945.6 CDI87699.1 - 3.4 7.7 26.8 5.1 7.2 26.8 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF2370 PF10176.9 CDI87699.1 - 3.9 7.1 11.5 3.7 7.1 11.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) MAP17 PF15807.5 CDI87699.1 - 4.2 7.6 13.9 4.7 7.5 13.9 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SLC12 PF03522.15 CDI87699.1 - 4.3 6.2 19.8 4.8 6.1 19.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CSG2 PF16965.5 CDI87699.1 - 4.6 6.1 12.6 4.8 6.0 12.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator DDRGK PF09756.9 CDI87699.1 - 4.7 6.7 25.9 5.7 6.5 25.9 1.0 1 0 0 1 1 1 0 DDRGK domain Band_3_cyto PF07565.13 CDI87699.1 - 4.9 6.9 22.2 5.1 6.8 22.2 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DDHD PF02862.17 CDI87699.1 - 5 7.2 18.5 5.4 7.1 18.5 1.0 1 0 0 1 1 1 0 DDHD domain DUF5308 PF17233.2 CDI87699.1 - 5.1 7.3 16.5 7 6.9 16.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Peptidase_S49_N PF08496.10 CDI87699.1 - 5.2 7.1 19.4 6.8 6.7 19.4 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ureide_permease PF07168.11 CDI87699.1 - 5.4 5.7 10.0 5.9 5.5 10.0 1.0 1 0 0 1 1 1 0 Ureide permease Paf1 PF03985.13 CDI87699.1 - 5.5 5.9 22.0 6.3 5.7 22.0 1.0 1 0 0 1 1 1 0 Paf1 RBM39linker PF15519.6 CDI87699.1 - 5.6 8.1 14.4 8 7.6 14.4 1.3 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein Peptidase_S64 PF08192.11 CDI87699.1 - 6.2 5.2 17.1 7.1 5.0 17.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 FAM91_C PF14648.6 CDI87699.1 - 6.3 5.5 12.3 7.1 5.3 12.3 1.0 1 0 0 1 1 1 0 FAM91 C-terminus DUF4820 PF16091.5 CDI87699.1 - 6.6 6.0 14.3 8.6 5.7 14.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) PPL5 PF18168.1 CDI87699.1 - 6.7 5.9 14.5 7.4 5.8 14.5 1.0 1 0 0 1 1 1 0 Prim-pol family 5 FAM60A PF15396.6 CDI87699.1 - 6.8 6.6 16.0 7.6 6.5 16.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A MDM31_MDM32 PF08118.11 CDI87699.1 - 7.1 5.2 14.5 8 5.0 14.5 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins CLN3 PF02487.17 CDI87699.1 - 7.1 5.6 17.3 7.7 5.4 17.3 1.0 1 0 0 1 1 1 0 CLN3 protein TERB2 PF15101.6 CDI87699.1 - 7.5 6.5 26.3 8.3 6.4 26.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 MDM10 PF12519.8 CDI87699.1 - 8.2 5.2 17.1 9.1 5.0 17.1 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 MPM1 PF17234.2 CDI87699.1 - 8.4 6.6 22.3 10 6.3 22.3 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 REC114-like PF15165.6 CDI87699.1 - 9.7 5.9 23.5 11 5.7 23.5 1.0 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like PAT1 PF09770.9 CDI87699.1 - 9.8 4.3 33.3 9.9 4.3 33.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF853 PF05872.12 CDI87699.1 - 9.9 4.6 15.1 11 4.5 15.1 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Aldo_ket_red PF00248.21 CDI87701.1 - 1.5e-07 30.9 0.0 2.9e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Aldo/keto reductase family PAS_4 PF08448.10 CDI87701.1 - 0.017 15.3 0.1 0.27 11.5 0.0 2.3 1 1 1 2 2 2 0 PAS fold Pkinase PF00069.25 CDI87702.1 - 1.3e-05 24.7 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DOR PF14839.6 CDI87702.1 - 0.037 14.0 2.2 0.043 13.8 2.2 1.2 1 0 0 1 1 1 0 DOR family Shisa PF13908.6 CDI87702.1 - 0.1 12.9 4.7 0.14 12.4 4.7 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF16 PF01519.16 CDI87703.1 - 0.059 13.9 6.5 0.46 11.0 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 Syntaxin-6_N PF09177.11 CDI87703.1 - 0.061 13.9 4.6 0.19 12.3 0.0 2.6 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF3450 PF11932.8 CDI87703.1 - 0.59 9.4 11.9 2.6 7.3 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF1993 PF09351.10 CDI87703.1 - 0.77 9.9 6.6 0.81 9.8 5.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1993) DUF1664 PF07889.12 CDI87703.1 - 1.1 9.3 5.3 2.8 8.0 4.2 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) BRE1 PF08647.11 CDI87703.1 - 1.5 9.0 11.1 1.4 9.0 5.7 2.3 1 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase YabA PF06156.13 CDI87703.1 - 1.9 9.2 10.2 2.5 8.8 0.9 2.8 1 1 2 3 3 3 0 Initiation control protein YabA TMF_TATA_bd PF12325.8 CDI87703.1 - 2.1 8.6 13.8 0.11 12.8 6.2 2.4 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding UPF0242 PF06785.11 CDI87703.1 - 2.6 8.1 13.8 3.9 7.5 0.6 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SlyX PF04102.12 CDI87703.1 - 3 8.5 9.3 0.98 10.1 1.6 2.7 2 1 1 3 3 3 0 SlyX V_ATPase_I PF01496.19 CDI87703.1 - 4.8 5.0 9.6 12 3.6 1.1 1.7 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Seryl_tRNA_N PF02403.22 CDI87703.1 - 7.5 6.8 13.6 6.7 7.0 1.8 2.4 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain BBIP10 PF14777.6 CDI87704.1 - 0.085 12.4 0.6 0.2 11.2 0.6 1.7 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 Rtf2 PF04641.12 CDI87705.1 - 2.8 7.2 20.5 3 7.1 20.5 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2370 PF10176.9 CDI87705.1 - 3 7.4 15.1 3.1 7.4 15.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF3306 PF11748.8 CDI87705.1 - 3.8 8.4 16.7 5.2 8.0 16.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Kei1 PF08552.11 CDI87705.1 - 4.1 7.3 18.0 4.5 7.1 18.0 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Afi1 PF07792.12 CDI87705.1 - 4.3 7.8 18.6 4.7 7.7 18.6 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Sec62 PF03839.16 CDI87705.1 - 4.9 6.6 21.0 5.2 6.5 21.0 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 CDI87705.1 - 5 5.8 25.1 5.2 5.7 25.1 1.0 1 0 0 1 1 1 0 Presenilin LsmAD PF06741.13 CDI87705.1 - 5.1 7.7 10.3 8.9 6.9 10.3 1.5 1 1 0 1 1 1 0 LsmAD domain zf-CpG_bind_C PF12269.8 CDI87705.1 - 5.5 6.7 21.1 6.1 6.6 21.1 1.0 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain PNISR PF15996.5 CDI87705.1 - 6.4 7.0 25.9 7.3 6.8 25.9 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR MDM10 PF12519.8 CDI87705.1 - 7.6 5.3 22.5 8.3 5.2 22.5 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Peptidase_S64 PF08192.11 CDI87705.1 - 7.8 4.8 20.8 8.3 4.8 20.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF3499 PF12005.8 CDI87705.1 - 7.9 7.1 11.7 12 6.5 11.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3499) PIEZO PF15917.5 CDI87705.1 - 7.9 5.9 31.0 8.6 5.8 31.0 1.0 1 0 0 1 1 1 0 Piezo Tim54 PF11711.8 CDI87705.1 - 8 5.1 18.6 9.4 4.9 18.6 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PAP_PilO PF06864.12 CDI87708.1 - 0.083 11.7 11.3 0.097 11.5 11.3 1.1 1 0 0 1 1 1 0 Pilin accessory protein (PilO) Chlor_dismutase PF06778.12 CDI87708.1 - 0.26 10.8 5.9 0.29 10.7 5.9 1.0 1 0 0 1 1 1 0 Chlorite dismutase TFB6 PF17110.5 CDI87708.1 - 2.2 8.0 10.1 2.9 7.6 10.1 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CobT PF06213.12 CDI87708.1 - 2.4 7.5 20.7 2.7 7.3 20.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CAML PF14963.6 CDI87708.1 - 2.4 8.2 7.1 2.5 8.1 7.1 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand DUF4174 PF13778.6 CDI87708.1 - 2.9 8.4 18.6 3.5 8.1 18.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) OATP PF03137.20 CDI87708.1 - 5.8 5.1 9.3 6.1 5.0 9.3 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CPSF100_C PF13299.6 CDI87708.1 - 6.6 6.9 12.9 8.6 6.5 12.9 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal OAD_gamma PF04277.13 CDI87708.1 - 8.3 7.1 5.3 21 5.8 5.3 1.8 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Pet20 PF08692.10 CDI87708.1 - 8.4 7.1 11.0 10 6.8 11.0 1.2 1 0 0 1 1 1 0 Mitochondrial protein Pet20 GRP PF07172.11 CDI87708.1 - 9.6 7.0 8.9 1.3 9.7 4.7 1.6 1 1 1 2 2 2 0 Glycine rich protein family ExbD PF02472.16 CDI87708.1 - 9.8 6.4 14.5 11 6.2 14.5 1.0 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR DUF3824 PF12868.7 CDI87709.1 - 0.0014 19.3 10.4 0.0018 18.9 10.4 1.2 1 0 0 1 1 1 1 Domain of unknwon function (DUF3824) CPSF73-100_C PF11718.8 CDI87709.1 - 0.0059 16.2 4.8 0.0064 16.1 4.8 1.0 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Trp_oprn_chp PF09534.10 CDI87709.1 - 0.0085 15.9 3.0 0.0098 15.7 3.0 1.1 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) OATP PF03137.20 CDI87709.1 - 0.016 13.5 5.8 0.016 13.5 5.8 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family THOC2_N PF16134.5 CDI87709.1 - 0.027 13.1 6.6 0.028 13.0 6.6 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus AIF_C PF14721.6 CDI87709.1 - 0.047 14.0 7.6 0.05 14.0 7.6 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CD20 PF04103.15 CDI87709.1 - 0.063 13.4 0.6 0.062 13.4 0.6 1.1 1 0 0 1 1 1 0 CD20-like family DUF4820 PF16091.5 CDI87709.1 - 0.079 12.3 8.6 0.088 12.2 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Connexin PF00029.19 CDI87709.1 - 0.087 12.6 6.2 0.084 12.6 6.2 1.0 1 0 0 1 1 1 0 Connexin DcuA_DcuB PF03605.14 CDI87709.1 - 0.12 11.2 2.8 0.11 11.3 2.8 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Spt5_N PF11942.8 CDI87709.1 - 0.14 13.2 11.1 0.15 13.0 11.1 1.2 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal BAF1_ABF1 PF04684.13 CDI87709.1 - 0.14 11.2 10.2 0.15 11.1 10.2 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Orf78 PF06024.12 CDI87709.1 - 0.17 12.2 3.1 0.17 12.2 3.1 1.2 1 0 0 1 1 1 0 Orf78 (ac78) Cytochrom_C_asm PF01578.20 CDI87709.1 - 0.19 11.5 0.2 0.23 11.2 0.2 1.1 1 0 0 1 1 1 0 Cytochrome C assembly protein CbiD PF01888.17 CDI87709.1 - 0.19 11.0 4.7 0.22 10.8 4.7 1.1 1 0 0 1 1 1 0 CbiD PIG-U PF06728.13 CDI87709.1 - 0.25 10.4 0.8 0.33 10.0 0.8 1.2 1 0 0 1 1 1 0 GPI transamidase subunit PIG-U 2HCT PF03390.15 CDI87709.1 - 0.25 9.9 0.5 0.25 9.9 0.5 1.0 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family Renin_r PF07850.14 CDI87709.1 - 0.29 11.8 2.9 0.32 11.6 2.9 1.2 1 0 0 1 1 1 0 Renin receptor-like protein SelP_N PF04592.14 CDI87709.1 - 0.3 10.5 13.9 0.3 10.4 13.9 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF1764 PF08576.10 CDI87709.1 - 0.3 12.0 8.7 0.36 11.7 8.7 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) FHIPEP PF00771.20 CDI87709.1 - 0.33 9.4 8.6 0.32 9.4 8.6 1.0 1 0 0 1 1 1 0 FHIPEP family Glt_symporter PF03616.14 CDI87709.1 - 0.36 9.5 2.3 0.36 9.5 2.3 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter R_equi_Vir PF05526.11 CDI87709.1 - 0.37 10.6 7.5 0.38 10.6 7.5 1.0 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein CTU2 PF10288.9 CDI87709.1 - 0.4 10.9 8.3 0.45 10.8 8.3 1.2 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 HA2 PF04408.23 CDI87709.1 - 0.43 10.9 8.5 0.47 10.8 8.5 1.1 1 0 0 1 1 1 0 Helicase associated domain (HA2) Folate_carrier PF01770.18 CDI87709.1 - 0.47 9.1 7.3 0.46 9.2 7.3 1.0 1 0 0 1 1 1 0 Reduced folate carrier Pex14_N PF04695.13 CDI87709.1 - 0.59 10.8 19.5 0.66 10.6 19.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Peptidase_S49_N PF08496.10 CDI87709.1 - 0.6 10.2 8.6 0.68 10.0 8.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal HemX PF04375.14 CDI87709.1 - 0.63 9.3 26.3 0.71 9.1 26.3 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase TFB6 PF17110.5 CDI87709.1 - 0.63 9.8 4.9 0.68 9.7 4.9 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH FAM60A PF15396.6 CDI87709.1 - 0.63 10.0 8.2 0.66 9.9 8.2 1.0 1 0 0 1 1 1 0 Protein Family FAM60A EIIBC-GUT_N PF03612.14 CDI87709.1 - 0.67 9.7 9.5 0.7 9.6 9.5 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Baculo_PP31 PF05311.11 CDI87709.1 - 0.8 9.1 12.0 0.83 9.1 12.0 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DcuC PF03606.15 CDI87709.1 - 0.83 8.0 2.1 0.79 8.1 2.1 1.0 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier Zip PF02535.22 CDI87709.1 - 0.84 8.8 4.1 0.84 8.8 4.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Serinc PF03348.15 CDI87709.1 - 1.1 8.1 9.1 1.1 8.1 9.1 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) EphA2_TM PF14575.6 CDI87709.1 - 1.2 10.0 10.5 3.6 8.5 10.5 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4770 PF15994.5 CDI87709.1 - 1.2 9.3 15.7 1.5 9.1 15.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Ctr PF04145.15 CDI87709.1 - 1.3 9.6 6.0 1.3 9.6 6.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Glyco_hydro_9 PF00759.19 CDI87709.1 - 1.3 8.3 11.7 1.5 8.2 11.7 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 RRT14 PF17075.5 CDI87709.1 - 1.3 9.1 13.3 1.4 9.0 13.3 1.0 1 0 0 1 1 1 0 Regular of rDNA transcription protein 14 SpoIIP PF07454.11 CDI87709.1 - 1.6 8.1 11.1 1.7 8.0 11.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF3675 PF12428.8 CDI87709.1 - 1.6 9.3 4.7 1.8 9.1 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) RR_TM4-6 PF06459.12 CDI87709.1 - 1.7 8.4 11.3 1.7 8.4 11.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Suf PF05843.14 CDI87709.1 - 1.7 8.5 14.8 1.8 8.5 14.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) G0-G1_switch_2 PF15103.6 CDI87709.1 - 2 8.8 9.1 2.4 8.7 9.1 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 EOS1 PF12326.8 CDI87709.1 - 2.1 8.2 6.5 2.2 8.2 6.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein Kei1 PF08552.11 CDI87709.1 - 2.2 8.1 10.6 2.3 8.1 10.6 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 V_ATPase_I PF01496.19 CDI87709.1 - 2.2 6.1 12.6 2.1 6.1 12.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_U57 PF05582.12 CDI87709.1 - 2.3 7.4 9.4 2.4 7.3 9.4 1.0 1 0 0 1 1 1 0 YabG peptidase U57 Rtf2 PF04641.12 CDI87709.1 - 2.4 7.5 10.9 2.4 7.4 10.9 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF3464 PF11947.8 CDI87709.1 - 2.5 7.9 11.3 2.7 7.7 11.3 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Gastrin PF00918.17 CDI87709.1 - 2.5 9.1 12.8 2.7 9.0 12.8 1.0 1 0 0 1 1 1 0 Gastrin/cholecystokinin family CSG2 PF16965.5 CDI87709.1 - 2.6 6.9 4.8 2.6 6.9 4.8 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator EPL1 PF10513.9 CDI87709.1 - 2.6 8.4 11.6 2.9 8.2 11.6 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF1980 PF09323.10 CDI87709.1 - 2.8 7.8 8.1 2.9 7.8 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF2828 PF11443.8 CDI87709.1 - 2.9 5.9 11.9 3 5.8 11.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Neur_chan_memb PF02932.16 CDI87709.1 - 3 7.9 8.5 2.8 7.9 8.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Pex26 PF07163.12 CDI87709.1 - 3.3 7.0 13.3 3.5 6.9 13.3 1.1 1 0 0 1 1 1 0 Pex26 protein PigN PF04987.14 CDI87709.1 - 3.4 6.4 8.8 3.5 6.4 8.8 1.0 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) MDM31_MDM32 PF08118.11 CDI87709.1 - 3.4 6.2 8.9 3.5 6.2 8.9 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Spt20 PF12090.8 CDI87709.1 - 3.5 7.2 33.6 3.9 7.0 33.6 1.2 1 0 0 1 1 1 0 Spt20 family DUF4175 PF13779.6 CDI87709.1 - 3.6 5.4 25.7 4 5.2 25.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CLN3 PF02487.17 CDI87709.1 - 3.9 6.4 8.3 4 6.4 8.3 1.0 1 0 0 1 1 1 0 CLN3 protein Ureide_permease PF07168.11 CDI87709.1 - 4 6.1 6.2 4.2 6.0 6.2 1.1 1 0 0 1 1 1 0 Ureide permease TERB2 PF15101.6 CDI87709.1 - 4 7.4 17.3 4.4 7.3 17.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TMEM51 PF15345.6 CDI87709.1 - 5 6.9 16.0 5.5 6.8 16.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Band_3_cyto PF07565.13 CDI87709.1 - 5.3 6.8 11.8 5.9 6.6 11.8 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TFIIA PF03153.13 CDI87709.1 - 5.7 6.8 35.7 5.9 6.8 35.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CPSF100_C PF13299.6 CDI87709.1 - 6.1 7.0 10.5 6.9 6.8 10.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4228 PF14009.6 CDI87709.1 - 7.1 7.0 9.2 7.8 6.9 9.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) MDM10 PF12519.8 CDI87709.1 - 7.1 5.4 10.4 7.7 5.3 10.4 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DDHD PF02862.17 CDI87709.1 - 7.5 6.6 12.3 7.8 6.6 12.3 1.0 1 0 0 1 1 1 0 DDHD domain Coilin_N PF15862.5 CDI87709.1 - 8.3 6.2 15.1 10 5.9 15.1 1.2 1 0 0 1 1 1 0 Coilin N-terminus eIF-3_zeta PF05091.12 CDI87709.1 - 8.7 5.2 18.1 9 5.1 18.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4199 PF13858.6 CDI87709.1 - 8.9 6.7 6.9 10 6.5 6.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Spt20 PF12090.8 CDI87710.1 - 0.0023 17.6 13.1 0.0031 17.2 13.1 1.3 1 0 0 1 1 1 1 Spt20 family DcuA_DcuB PF03605.14 CDI87710.1 - 0.0042 16.0 0.2 0.0044 16.0 0.2 1.0 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter DUF1345 PF07077.11 CDI87710.1 - 0.051 13.3 2.1 0.076 12.7 1.6 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) MSP1a PF11670.8 CDI87710.1 - 0.055 12.8 0.7 0.067 12.5 0.7 1.2 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) Pex26 PF07163.12 CDI87710.1 - 0.095 12.0 7.8 0.1 11.9 7.8 1.1 1 0 0 1 1 1 0 Pex26 protein SbcCD_C PF13558.6 CDI87710.1 - 0.28 11.5 3.8 0.22 11.8 0.4 2.1 1 1 1 2 2 2 0 Putative exonuclease SbcCD, C subunit MTABC_N PF16185.5 CDI87710.1 - 0.36 10.3 3.7 0.3 10.5 1.8 1.7 1 1 1 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region Orf78 PF06024.12 CDI87710.1 - 0.39 11.0 3.6 0.35 11.2 1.2 2.0 1 1 1 2 2 2 0 Orf78 (ac78) Pro-rich PF15240.6 CDI87710.1 - 0.53 10.6 17.8 1.7 8.9 17.3 1.8 1 1 0 1 1 1 0 Proline-rich TFIIA PF03153.13 CDI87710.1 - 0.78 9.7 15.9 0.94 9.4 15.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3357 PF11837.8 CDI87710.1 - 0.96 9.9 4.4 1.2 9.6 1.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) DUF243 PF03103.17 CDI87710.1 - 1.5 9.2 12.0 0.24 11.7 4.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF243) ABC2_membrane_2 PF12679.7 CDI87710.1 - 1.6 7.9 4.4 2.6 7.2 4.4 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein DOR PF14839.6 CDI87710.1 - 3 7.7 8.7 3.6 7.5 8.7 1.0 1 0 0 1 1 1 0 DOR family RskA PF10099.9 CDI87710.1 - 3.2 8.0 9.2 13 6.0 9.2 1.8 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Toxin-JAB1 PF15659.6 CDI87711.1 - 0.49 10.8 7.3 0.59 10.5 7.3 1.1 1 0 0 1 1 1 0 JAB-like toxin 1 V_ATPase_I PF01496.19 CDI87711.1 - 1.7 6.4 15.7 1.9 6.3 15.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family POPLD PF08170.12 CDI87711.1 - 2.6 8.4 7.7 3.8 7.9 7.7 1.3 1 0 0 1 1 1 0 POPLD (NUC188) domain DUF775 PF05603.12 CDI87711.1 - 3.8 7.0 14.1 4.6 6.7 14.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Zip PF02535.22 CDI87711.1 - 7.5 5.7 9.8 7.8 5.6 9.8 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 CDI87711.1 - 9.5 5.9 14.6 12 5.7 14.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zein PF01559.16 CDI87712.1 - 0.0077 15.8 21.0 0.011 15.4 21.0 1.3 1 0 0 1 1 1 1 Zein seed storage protein WSC PF01822.19 CDI87712.1 - 0.5 10.6 10.1 1.9 8.7 10.1 1.7 1 1 0 1 1 1 0 WSC domain Sec23_helical PF04815.15 CDI87713.1 - 1.4e-24 85.9 0.5 2.4e-24 85.1 0.5 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_trunk PF04811.15 CDI87713.1 - 3.9e-20 72.5 0.1 6.2e-20 71.8 0.1 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 CDI87713.1 - 5.4e-18 65.5 0.1 1.6e-16 60.8 0.0 2.3 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain TPR_1 PF00515.28 CDI87714.1 - 1.2e-22 78.7 1.5 2.1e-07 30.5 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDI87714.1 - 6.5e-21 72.7 0.8 5.3e-06 26.1 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDI87714.1 - 4e-18 64.0 0.9 0.00012 22.0 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDI87714.1 - 3.4e-15 55.4 0.7 2.1e-07 30.5 0.0 3.3 1 1 2 3 3 3 3 TPR repeat TPR_14 PF13428.6 CDI87714.1 - 4e-12 45.9 0.8 0.0027 18.4 0.6 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDI87714.1 - 2.3e-10 40.1 0.6 0.0024 18.1 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDI87714.1 - 6.1e-09 36.3 1.4 0.00039 20.9 0.0 3.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDI87714.1 - 9.7e-09 35.7 1.6 0.00011 22.7 0.0 2.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 CDI87714.1 - 9.9e-09 35.2 0.1 0.00028 21.0 0.1 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDI87714.1 - 3.4e-07 30.5 0.4 0.00024 21.4 0.0 2.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDI87714.1 - 4.5e-07 29.5 0.1 0.0061 16.5 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDI87714.1 - 7.8e-05 22.4 0.1 0.3 11.0 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat STI1 PF17830.1 CDI87714.1 - 0.00038 20.3 0.7 0.0013 18.6 0.4 2.1 1 1 0 1 1 1 1 STI1 domain NARP1 PF12569.8 CDI87714.1 - 0.00064 18.8 0.5 0.00096 18.2 0.4 1.3 1 1 0 1 1 1 1 NMDA receptor-regulated protein 1 Fis1_TPR_C PF14853.6 CDI87714.1 - 0.0065 16.5 0.7 0.56 10.3 0.0 3.0 4 1 0 4 4 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 CDI87714.1 - 0.0075 16.8 2.8 5.4 7.9 0.0 4.2 4 1 0 4 4 4 1 Tetratricopeptide repeat MAS20 PF02064.15 CDI87714.1 - 0.011 15.8 0.7 0.21 11.7 0.0 2.3 2 0 0 2 2 2 0 MAS20 protein import receptor TPR_20 PF14561.6 CDI87714.1 - 0.021 15.1 1.1 0.75 10.2 0.0 2.9 2 2 0 3 3 3 0 Tetratricopeptide repeat DUF3856 PF12968.7 CDI87714.1 - 0.03 14.4 0.2 0.28 11.2 0.2 2.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) SHNi-TPR PF10516.9 CDI87714.1 - 0.041 13.3 0.1 9 5.9 0.0 2.6 2 0 0 2 2 2 0 SHNi-TPR ANAPC3 PF12895.7 CDI87714.1 - 0.07 13.4 0.2 0.22 11.8 0.1 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 HemY_N PF07219.13 CDI87714.1 - 0.092 13.0 3.5 0.3 11.3 0.1 2.4 1 1 0 2 2 2 0 HemY protein N-terminus GST_C_3 PF14497.6 CDI87714.1 - 0.21 11.8 1.1 1.3 9.2 0.1 2.4 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain ACDC PF14733.6 CDI87715.1 - 0.0035 17.6 0.0 0.0064 16.8 0.0 1.4 1 0 0 1 1 1 1 AP2-coincident C-terminal YqfQ PF14181.6 CDI87715.1 - 0.072 13.3 7.0 0.12 12.5 1.0 2.5 2 0 0 2 2 2 0 YqfQ-like protein Herpes_env PF01673.18 CDI87715.1 - 0.11 11.3 2.8 0.14 11.0 2.8 1.1 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein TAF4 PF05236.14 CDI87715.1 - 2.9 7.6 17.7 2.3 7.9 7.3 2.2 1 1 1 2 2 2 0 Transcription initiation factor TFIID component TAF4 family FSA_C PF10479.9 CDI87715.1 - 9.3 4.2 8.0 14 3.6 8.0 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus CRAL_TRIO PF00650.20 CDI87717.1 - 3.4e-06 26.9 0.0 1.1e-05 25.2 0.0 1.7 2 0 0 2 2 2 1 CRAL/TRIO domain LRR19-TM PF15176.6 CDI87718.1 - 0.00058 19.8 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain DUF3168 PF11367.8 CDI87718.1 - 0.096 12.9 0.0 0.88 9.8 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3168) Peptidase_S49_N PF08496.10 CDI87718.1 - 0.13 12.3 0.1 0.62 10.1 0.3 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal FAM176 PF14851.6 CDI87718.1 - 0.36 10.5 3.9 0.3 10.8 0.2 2.5 2 0 0 2 2 2 0 FAM176 family SHR-BD PF06650.12 CDI87721.1 - 0.0035 16.8 0.0 0.0035 16.8 0.0 3.6 4 0 0 4 4 4 2 SHR-binding domain of vacuolar-sorting associated protein 13 TFIIA PF03153.13 CDI87721.1 - 0.0048 17.0 30.6 0.0048 17.0 30.6 2.6 4 0 0 4 4 4 1 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI87721.1 - 0.31 9.7 16.9 0.66 8.7 16.9 1.4 1 0 0 1 1 1 0 Presenilin DUF2828 PF11443.8 CDI87721.1 - 2 6.4 6.8 2.8 5.9 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CTU2 PF10288.9 CDI87721.1 - 7 6.9 18.5 0.057 13.7 3.8 2.8 3 0 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 Asp-B-Hydro_N PF05279.11 CDI87722.1 - 3.1 7.8 24.3 4.7 7.2 24.3 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Sin_N PF04801.13 CDI87722.1 - 4.3 6.4 39.5 8.9 5.4 39.5 1.6 1 0 0 1 1 1 0 Sin-like protein conserved region ALMT PF11744.8 CDI87722.1 - 5.6 5.7 21.0 9.7 4.9 21.0 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 CDI87722.1 - 7.6 4.7 26.0 12 4.1 26.0 1.3 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_60s PF00428.19 CDI87723.1 - 0.027 15.0 12.3 0.027 15.0 12.3 4.6 4 1 1 5 5 5 0 60s Acidic ribosomal protein AAA_23 PF13476.6 CDI87723.1 - 1 9.8 21.0 2.3 8.7 21.0 1.6 1 0 0 1 1 1 0 AAA domain GDP_Man_Dehyd PF16363.5 CDI87724.1 - 5.5e-31 108.2 0.1 8.9e-23 81.2 0.1 3.0 1 1 2 3 3 3 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDI87724.1 - 4.6e-25 88.5 0.1 1.8e-22 80.0 0.1 2.1 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CDI87724.1 - 8.9e-11 41.3 0.0 1.4e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CDI87724.1 - 2.2e-10 40.2 0.0 8e-10 38.3 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CDI87724.1 - 8.9e-07 28.3 0.0 1.5e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 CDI87724.1 - 0.00024 21.1 0.0 0.00039 20.4 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 CDI87724.1 - 0.0004 19.9 0.0 0.00056 19.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase 3HCDH_N PF02737.18 CDI87724.1 - 0.025 14.5 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CDI87724.1 - 0.077 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_10 PF13460.6 CDI87724.1 - 0.098 12.5 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding NmrA PF05368.13 CDI87724.1 - 0.11 12.1 0.1 0.3 10.6 0.0 1.7 2 0 0 2 2 2 0 NmrA-like family NAD_binding_4 PF07993.12 CDI87724.1 - 0.11 11.6 0.3 0.96 8.6 0.0 2.0 1 1 1 2 2 2 0 Male sterility protein adh_short_C2 PF13561.6 CDI87724.1 - 0.15 11.6 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase NAD_binding_2 PF03446.15 CDI87724.1 - 0.17 12.0 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase PXT1 PF15214.6 CDI87727.1 - 0.083 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Peroxisomal testis-specific protein 1 Peptidase_M16_M PF16187.5 CDI87728.1 - 1e-13 51.2 0.3 2.1e-07 30.5 0.7 2.6 1 1 1 2 2 2 2 Middle or third domain of peptidase_M16 Med15 PF09606.10 CDI87728.1 - 0.0032 16.2 3.1 0.0032 16.2 3.1 2.0 2 0 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI87728.1 - 0.058 13.4 27.2 0.18 11.8 27.2 1.7 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4611 PF15387.6 CDI87728.1 - 0.21 11.8 0.1 0.21 11.8 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Connexin PF00029.19 CDI87728.1 - 0.74 9.5 4.5 9.7 5.9 2.2 2.4 3 0 0 3 3 3 0 Connexin AIM3 PF17096.5 CDI87728.1 - 0.96 10.4 7.6 5.2 8.1 3.9 2.6 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 U1snRNP70_N PF12220.8 CDI87728.1 - 1.6 9.4 16.3 2.8 8.6 1.1 2.8 3 0 0 3 3 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4834 PF16118.5 CDI87728.1 - 2.1 9.3 16.2 0.61 11.1 0.4 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF2722 PF10846.8 CDI87728.1 - 2.4 7.0 23.8 0.02 13.8 5.6 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) FAM176 PF14851.6 CDI87728.1 - 4.5 6.9 9.9 11 5.7 0.0 2.3 2 0 0 2 2 2 0 FAM176 family AIF_C PF14721.6 CDI87728.1 - 4.5 7.7 10.2 46 4.4 6.2 2.6 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Tom22 PF04281.13 CDI87728.1 - 7.4 6.4 13.0 6.2 6.6 0.2 2.6 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 FYDLN_acid PF09538.10 CDI87728.1 - 9.5 7.0 14.1 8.5 7.1 4.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) AP2 PF00847.20 CDI87729.1 - 1.6e-05 25.0 2.4 1.6e-05 25.0 2.4 3.4 3 0 0 3 3 3 1 AP2 domain TetR_C_36 PF18598.1 CDI87730.1 - 0.045 13.7 0.7 1.2 9.2 0.1 3.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF2293 PF10056.9 CDI87730.1 - 1.3 9.3 3.6 0.52 10.6 0.6 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2293) Rad10 PF03834.14 CDI87731.1 - 2.2e-25 88.9 0.0 3.8e-25 88.1 0.0 1.4 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH PF00633.23 CDI87731.1 - 0.00032 20.4 0.0 0.0008 19.2 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif Ndc1_Nup PF09531.10 CDI87731.1 - 0.0047 15.7 6.2 0.0071 15.1 6.2 1.4 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup HHH_2 PF12826.7 CDI87731.1 - 0.0058 16.7 0.0 0.016 15.3 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif Tfb4 PF03850.14 CDI87731.1 - 0.019 14.4 0.1 0.029 13.9 0.1 1.3 1 0 0 1 1 1 0 Transcription factor Tfb4 Pkinase_fungal PF17667.1 CDI87731.1 - 0.12 11.1 0.7 0.16 10.7 0.7 1.2 1 0 0 1 1 1 0 Fungal protein kinase Tim54 PF11711.8 CDI87731.1 - 0.39 9.4 12.5 0.7 8.6 12.5 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SpoIIP PF07454.11 CDI87731.1 - 1.3 8.4 15.1 2.3 7.6 15.1 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) OATP PF03137.20 CDI87731.1 - 1.5 7.0 4.8 2.4 6.4 4.8 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Pex14_N PF04695.13 CDI87731.1 - 2.1 9.0 39.6 0.85 10.3 34.8 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FemAB PF02388.16 CDI87731.1 - 2.8 6.7 10.7 4.4 6.1 10.7 1.2 1 0 0 1 1 1 0 FemAB family Peptidase_S49_N PF08496.10 CDI87731.1 - 3.6 7.6 7.5 8.1 6.5 7.5 1.6 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CDC45 PF02724.14 CDI87731.1 - 4.5 5.5 9.7 6.3 5.0 9.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2877 PF11392.8 CDI87731.1 - 7 7.4 6.9 12 6.6 0.0 3.8 3 2 1 4 4 3 0 Protein of unknown function (DUF2877) Band_3_cyto PF07565.13 CDI87731.1 - 8.6 6.1 11.5 19 5.0 11.5 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CLN3 PF02487.17 CDI87731.1 - 9.1 5.2 9.5 15 4.5 9.5 1.3 1 0 0 1 1 1 0 CLN3 protein EPL1 PF10513.9 CDI87731.1 - 9.8 6.5 16.2 1.1 9.7 11.5 1.8 2 0 0 2 2 1 0 Enhancer of polycomb-like Glycolytic PF00274.19 CDI87732.1 - 3.5e-168 558.8 0.0 3.9e-168 558.6 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I SR-25 PF10500.9 CDI87733.1 - 4.7e-05 23.1 7.0 5.6e-05 22.9 7.0 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein OmpH PF03938.14 CDI87733.1 - 0.00079 19.8 18.0 0.00084 19.7 18.0 1.1 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) Pex14_N PF04695.13 CDI87733.1 - 0.0023 18.6 18.5 0.0026 18.5 18.5 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 CDI87733.1 - 0.0036 16.9 27.5 0.0041 16.8 27.5 1.2 1 0 0 1 1 1 1 Spt20 family DUF4764 PF15961.5 CDI87733.1 - 0.0061 15.3 11.9 0.0071 15.1 11.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) Suf PF05843.14 CDI87733.1 - 0.014 15.4 16.7 0.016 15.2 16.7 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CCSAP PF15748.5 CDI87733.1 - 0.016 15.4 11.4 0.017 15.3 11.4 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated TFIIA PF03153.13 CDI87733.1 - 0.019 15.0 26.9 0.021 14.9 26.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Membr_traf_MHD PF10540.9 CDI87733.1 - 0.029 14.6 4.9 0.037 14.2 4.9 1.4 1 0 0 1 1 1 0 Munc13 (mammalian uncoordinated) homology domain DUF5352 PF17303.2 CDI87733.1 - 0.03 14.2 1.6 0.034 14.0 1.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5352) DUF4050 PF13259.6 CDI87733.1 - 0.033 14.5 13.6 0.041 14.2 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Adaptin_binding PF10199.9 CDI87733.1 - 0.053 14.1 10.4 0.062 13.9 10.4 1.1 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 GvpL_GvpF PF06386.11 CDI87733.1 - 0.055 13.4 6.6 0.061 13.3 6.6 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Folate_carrier PF01770.18 CDI87733.1 - 0.063 12.0 5.9 0.062 12.0 5.9 1.0 1 0 0 1 1 1 0 Reduced folate carrier Sox_N PF12444.8 CDI87733.1 - 0.068 14.3 8.1 0.12 13.6 8.1 1.4 1 0 0 1 1 1 0 Sox developmental protein N terminal Tim54 PF11711.8 CDI87733.1 - 0.072 11.9 9.5 0.082 11.7 9.5 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 eIF3_p135 PF12807.7 CDI87733.1 - 0.074 13.1 5.1 0.083 12.9 5.1 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 SpoIIP PF07454.11 CDI87733.1 - 0.074 12.5 9.5 0.074 12.5 9.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) eIF-3_zeta PF05091.12 CDI87733.1 - 0.075 12.0 11.6 0.083 11.9 11.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Neur_chan_memb PF02932.16 CDI87733.1 - 0.08 13.0 7.9 0.081 13.0 7.9 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Nop53 PF07767.11 CDI87733.1 - 0.096 12.1 12.5 0.11 11.9 12.5 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SMYLE_N PF18615.1 CDI87733.1 - 0.11 12.1 12.2 0.12 11.9 12.2 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain DUF5580 PF17743.1 CDI87733.1 - 0.12 10.9 12.3 0.14 10.7 12.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) EIIBC-GUT_N PF03612.14 CDI87733.1 - 0.13 12.0 9.1 0.15 11.8 9.1 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF2126 PF09899.9 CDI87733.1 - 0.13 10.3 7.8 0.14 10.2 7.8 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF4175 PF13779.6 CDI87733.1 - 0.13 10.1 21.1 0.14 10.0 21.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PGA_cap PF09587.10 CDI87733.1 - 0.13 11.6 2.6 0.14 11.5 2.6 1.1 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap CCDC53 PF10152.9 CDI87733.1 - 0.14 12.6 10.9 0.16 12.4 10.9 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex ASD2 PF08687.11 CDI87733.1 - 0.14 11.7 13.4 0.17 11.4 13.4 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Peptidase_C58 PF03543.14 CDI87733.1 - 0.15 11.7 12.8 0.17 11.6 12.8 1.1 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen TCP PF03634.13 CDI87733.1 - 0.17 12.4 14.5 0.21 12.1 14.5 1.1 1 0 0 1 1 1 0 TCP family transcription factor TFB6 PF17110.5 CDI87733.1 - 0.2 11.4 5.8 0.22 11.2 5.8 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Velvet PF11754.8 CDI87733.1 - 0.2 11.5 15.6 0.22 11.4 15.6 1.0 1 0 0 1 1 1 0 Velvet factor PARM PF17061.5 CDI87733.1 - 0.21 11.7 13.7 0.23 11.6 13.7 1.0 1 0 0 1 1 1 0 PARM DUF5521 PF17659.1 CDI87733.1 - 0.21 9.4 10.5 0.23 9.2 10.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5521) DDHD PF02862.17 CDI87733.1 - 0.21 11.7 12.0 0.24 11.5 12.0 1.1 1 0 0 1 1 1 0 DDHD domain DUF3464 PF11947.8 CDI87733.1 - 0.23 11.2 11.0 0.29 10.9 11.0 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Caudo_TAP PF02413.17 CDI87733.1 - 0.27 11.4 12.9 0.35 11.0 12.9 1.3 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK DUF913 PF06025.12 CDI87733.1 - 0.29 10.1 8.9 0.31 10.0 8.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hamartin PF04388.12 CDI87733.1 - 0.3 9.7 16.2 0.35 9.5 16.2 1.0 1 0 0 1 1 1 0 Hamartin protein Ndc1_Nup PF09531.10 CDI87733.1 - 0.3 9.7 12.7 0.32 9.7 12.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CPSF100_C PF13299.6 CDI87733.1 - 0.33 11.1 10.8 0.4 10.8 10.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Androgen_recep PF02166.16 CDI87733.1 - 0.33 9.8 25.5 0.41 9.4 25.5 1.1 1 0 0 1 1 1 0 Androgen receptor Connexin PF00029.19 CDI87733.1 - 0.4 10.4 5.8 0.46 10.2 5.8 1.1 1 0 0 1 1 1 0 Connexin Activator_LAG-3 PF11498.8 CDI87733.1 - 0.43 9.5 31.7 0.45 9.4 31.7 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 GET2 PF08690.10 CDI87733.1 - 0.45 10.1 16.4 0.61 9.7 16.4 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 Het-C PF07217.11 CDI87733.1 - 0.49 8.9 8.2 0.54 8.7 8.2 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C ICE2 PF08426.10 CDI87733.1 - 0.53 9.3 6.3 0.56 9.3 6.3 1.2 1 0 0 1 1 1 0 ICE2 Presenilin PF01080.17 CDI87733.1 - 0.55 8.9 15.5 0.61 8.8 15.5 1.1 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 CDI87733.1 - 0.55 8.4 19.5 0.58 8.4 19.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI87733.1 - 0.56 7.3 15.1 0.63 7.1 15.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Med3 PF11593.8 CDI87733.1 - 0.61 9.2 23.2 0.8 8.8 23.2 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FAM60A PF15396.6 CDI87733.1 - 0.65 10.0 9.7 0.78 9.7 9.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Band_3_cyto PF07565.13 CDI87733.1 - 0.67 9.7 11.5 0.78 9.5 11.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MAJIN PF15077.6 CDI87733.1 - 0.7 9.6 9.6 0.8 9.5 9.6 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Glycophorin_A PF01102.18 CDI87733.1 - 0.76 10.0 8.6 1 9.6 8.6 1.2 1 0 0 1 1 1 0 Glycophorin A EOS1 PF12326.8 CDI87733.1 - 0.78 9.7 7.3 0.89 9.5 7.3 1.1 1 0 0 1 1 1 0 N-glycosylation protein Cnd1_N PF12922.7 CDI87733.1 - 0.8 9.5 11.1 0.54 10.1 9.9 1.3 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term DUF908 PF06012.12 CDI87733.1 - 0.82 9.0 17.4 0.93 8.8 17.4 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Nucleoside_tran PF01733.18 CDI87733.1 - 0.85 8.9 3.6 0.93 8.8 3.6 1.1 1 0 0 1 1 1 0 Nucleoside transporter Roughex PF06020.11 CDI87733.1 - 0.85 8.7 12.2 0.99 8.4 12.2 1.3 1 0 0 1 1 1 0 Drosophila roughex protein LCIB_C_CA PF18599.1 CDI87733.1 - 0.91 8.8 9.2 1.1 8.5 9.2 1.1 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases RR_TM4-6 PF06459.12 CDI87733.1 - 0.97 9.2 14.0 1.1 9.0 14.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 OATP PF03137.20 CDI87733.1 - 0.98 7.6 5.1 1.1 7.5 5.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Zip PF02535.22 CDI87733.1 - 1 8.5 8.6 1.2 8.3 8.6 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Hydin_ADK PF17213.3 CDI87733.1 - 1.3 9.2 13.9 1.6 9.0 13.9 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain MscS_TM PF12794.7 CDI87733.1 - 1.5 7.6 12.2 2 7.2 12.2 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 RICTOR_N PF14664.6 CDI87733.1 - 1.6 7.6 6.4 1.8 7.4 6.4 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term YhfC PF10086.9 CDI87733.1 - 1.7 7.9 4.7 2 7.7 4.7 1.2 1 0 0 1 1 1 0 YhfC intramembrane metalloprotease PepSY_TM PF03929.16 CDI87733.1 - 1.9 8.1 5.5 2 8.0 5.5 1.1 1 0 0 1 1 1 0 PepSY-associated TM region SprA-related PF12118.8 CDI87733.1 - 2 7.4 25.8 3.2 6.8 25.8 1.3 1 0 0 1 1 1 0 SprA-related family SLC12 PF03522.15 CDI87733.1 - 2.1 7.3 14.8 2.5 7.0 14.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DnaJ-X PF14308.6 CDI87733.1 - 2.2 7.7 14.8 2.9 7.3 14.8 1.3 1 1 0 1 1 1 0 X-domain of DnaJ-containing Hid1 PF12722.7 CDI87733.1 - 2.5 6.1 16.1 2.7 6.0 16.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Dicty_REP PF05086.12 CDI87733.1 - 2.6 5.9 15.7 2.9 5.7 15.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Plasmodium_Vir PF05795.11 CDI87733.1 - 3 7.2 5.7 3.1 7.1 5.7 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Bul1_N PF04425.12 CDI87733.1 - 3.1 6.5 15.2 3.5 6.3 15.2 1.0 1 0 0 1 1 1 0 Bul1 N terminus Membralin PF09746.9 CDI87733.1 - 3.3 6.6 10.2 3.6 6.5 10.2 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF4400 PF14348.6 CDI87733.1 - 3.4 7.1 7.0 4.2 6.8 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) ALMT PF11744.8 CDI87733.1 - 3.7 6.3 10.0 3.9 6.2 10.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Coilin_N PF15862.5 CDI87733.1 - 4 7.2 18.5 5.6 6.8 18.5 1.2 1 0 0 1 1 1 0 Coilin N-terminus Gti1_Pac2 PF09729.9 CDI87733.1 - 4.1 7.5 11.9 5.1 7.2 11.9 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family CSG2 PF16965.5 CDI87733.1 - 7.5 5.4 9.9 8.5 5.2 9.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator WASH-7_C PF14746.6 CDI87733.1 - 8.4 6.1 15.6 10 5.8 15.1 1.3 1 1 0 1 1 1 0 WASH complex subunit 7, C-terminal Sec62 PF03839.16 CDI87733.1 - 8.7 5.8 8.9 9.9 5.6 8.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 CLN3 PF02487.17 CDI87733.1 - 9.8 5.1 11.2 11 4.9 11.2 1.1 1 0 0 1 1 1 0 CLN3 protein CobT PF06213.12 CDI87733.1 - 9.9 5.5 19.4 12 5.2 19.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Kei1 PF08552.11 CDI87733.1 - 10 6.0 13.1 12 5.7 13.1 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Cyclin PF08613.11 CDI87736.1 - 3e-30 105.7 0.1 3e-30 105.7 0.1 1.9 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 CDI87736.1 - 3.6e-11 42.9 0.7 6e-11 42.2 0.7 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain ketoacyl-synt PF00109.26 CDI87737.1 - 1.6e-75 254.0 0.1 5.5e-75 252.2 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CDI87737.1 - 1e-57 195.0 0.0 2.3e-57 193.8 0.0 1.7 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 CDI87737.1 - 2.3e-47 162.1 0.5 4.1e-47 161.2 0.5 1.4 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CDI87737.1 - 1.8e-44 152.2 0.3 2.9e-44 151.5 0.3 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CDI87737.1 - 1.1e-41 141.5 0.1 2.8e-41 140.2 0.1 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 CDI87737.1 - 7e-13 48.7 0.0 1.7e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 CDI87737.1 - 5.7e-10 39.0 0.0 1.5e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDI87737.1 - 3.3e-09 36.6 0.0 1e-08 35.0 0.0 1.8 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KAsynt_C_assoc PF16197.5 CDI87737.1 - 3.3e-08 34.0 0.0 9.1e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CDI87737.1 - 0.0001 21.7 0.2 0.00067 19.1 0.1 2.2 2 0 0 2 2 2 1 Thiolase, N-terminal domain Epimerase PF01370.21 CDI87737.1 - 0.00082 18.9 0.0 0.0016 17.9 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDI87737.1 - 0.0032 16.9 0.0 0.0052 16.2 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase DUF1015 PF06245.11 CDI87737.1 - 0.016 14.1 0.0 0.024 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) ACP_syn_III PF08545.10 CDI87737.1 - 0.061 13.2 0.6 0.18 11.7 0.6 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Polysacc_synt_2 PF02719.15 CDI87737.1 - 0.098 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 4HB PF17947.1 CDI87737.1 - 0.11 12.6 0.0 0.4 10.8 0.0 1.9 1 0 0 1 1 1 0 Four helical bundle domain Spt20 PF12090.8 CDI87738.1 - 0.0047 16.6 25.6 0.0067 16.1 25.6 1.4 1 0 0 1 1 1 1 Spt20 family SOG2 PF10428.9 CDI87738.1 - 1.8 7.7 14.5 2.9 7.0 14.5 1.4 1 1 0 1 1 1 0 RAM signalling pathway protein CorA PF01544.18 CDI87738.1 - 2.6 7.3 7.1 2 7.6 6.0 1.4 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein PepSY_TM PF03929.16 CDI87738.1 - 5.9 6.5 5.3 6.6 6.3 5.3 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Dicty_REP PF05086.12 CDI87738.1 - 8.8 4.2 16.9 9.2 4.1 16.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein UPF0051 PF01458.17 CDI87739.1 - 2.1e-09 37.4 5.0 2e-08 34.2 0.1 2.7 2 1 1 3 3 3 2 Uncharacterized protein family (UPF0051) DUF2844 PF11005.8 CDI87739.1 - 0.018 15.0 1.2 0.018 15.0 1.2 3.7 4 1 1 5 5 4 0 Protein of unknown function (DUF2844) SPX PF03105.19 CDI87739.1 - 0.044 13.7 19.7 0.072 13.0 19.7 1.3 1 0 0 1 1 1 0 SPX domain RskA PF10099.9 CDI87739.1 - 0.047 14.0 30.9 0.33 11.2 14.9 2.9 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Totivirus_coat PF05518.11 CDI87739.1 - 0.053 11.6 11.2 0.073 11.1 11.2 1.3 1 0 0 1 1 1 0 Totivirus coat protein OmpH PF03938.14 CDI87739.1 - 0.054 13.8 24.1 0.059 13.7 2.7 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Kin17_mid PF10357.9 CDI87739.1 - 0.058 13.3 0.9 0.058 13.3 0.9 2.3 2 0 0 2 2 2 0 Domain of Kin17 curved DNA-binding protein GRP PF07172.11 CDI87739.1 - 0.08 13.6 1.9 0.29 11.9 0.2 2.5 2 0 0 2 2 2 0 Glycine rich protein family SKIP_SNW PF02731.15 CDI87739.1 - 0.13 12.0 9.2 0.25 11.0 0.1 2.3 2 0 0 2 2 2 0 SKIP/SNW domain DUF4834 PF16118.5 CDI87739.1 - 0.31 12.0 18.2 1.8 9.6 5.6 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) TCP PF03634.13 CDI87739.1 - 0.4 11.2 19.3 0.87 10.1 6.6 2.3 2 0 0 2 2 2 0 TCP family transcription factor Activator_LAG-3 PF11498.8 CDI87739.1 - 0.52 9.2 49.3 0.034 13.1 11.4 2.3 2 0 0 2 2 2 0 Transcriptional activator LAG-3 TAF1D PF15333.6 CDI87739.1 - 0.67 9.6 13.9 0.018 14.8 4.2 2.1 2 0 0 2 2 2 0 TATA box-binding protein-associated factor 1D SelK_SelG PF10961.8 CDI87739.1 - 0.73 10.5 10.9 29 5.4 0.1 3.4 3 0 0 3 3 3 0 Selenoprotein SelK_SelG CagX PF03524.15 CDI87739.1 - 4.3 7.0 8.0 7.2 6.3 3.1 2.4 2 0 0 2 2 2 0 Conjugal transfer protein Conotoxin PF02950.17 CDI87739.1 - 5.8 8.0 10.6 1.2 10.2 1.6 3.2 3 0 0 3 3 3 0 Conotoxin HSP90 PF00183.18 CDI87740.1 - 2.4e-233 775.7 39.4 3.2e-233 775.3 39.4 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 CDI87740.1 - 3e-16 59.9 0.0 6e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CDI87740.1 - 7.1e-10 38.8 0.1 2.4e-09 37.1 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.9 CDI87740.1 - 0.0071 16.4 1.3 0.016 15.3 0.2 2.1 2 0 0 2 2 2 1 Tumour suppressor protein Cofac_haem_bdg PF04187.13 CDI87740.1 - 0.31 11.0 3.1 0.35 10.8 0.1 2.6 2 1 0 2 2 2 0 Haem-binding uptake, Tiki superfamily, ChaN Zip PF02535.22 CDI87740.1 - 0.78 8.9 3.7 1.3 8.2 3.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter TRAP_alpha PF03896.16 CDI87740.1 - 0.88 8.7 8.7 1.7 7.8 8.7 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Presenilin PF01080.17 CDI87740.1 - 1.7 7.3 8.0 2.7 6.6 8.0 1.3 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 CDI87740.1 - 3.9 5.7 18.1 6.2 5.0 18.1 1.2 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.14 CDI87740.1 - 4 7.9 12.6 8.6 6.8 12.6 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 GAGA_bind PF06217.12 CDI87740.1 - 7.3 6.8 14.1 4.9 7.4 11.2 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family Presenilin PF01080.17 CDI87741.1 - 2.1 7.0 47.1 2.2 7.0 47.1 1.0 1 0 0 1 1 1 0 Presenilin Rtf2 PF04641.12 CDI87741.1 - 3 7.1 32.9 3.4 7.0 32.9 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger NPR3 PF03666.13 CDI87741.1 - 4.3 6.0 37.9 5.3 5.7 37.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Band_3_cyto PF07565.13 CDI87741.1 - 6.4 6.5 40.2 7 6.4 40.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MitoNEET_N PF10660.9 CDI87742.1 - 0.15 12.1 0.2 0.29 11.2 0.2 1.4 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus DUF202 PF02656.15 CDI87742.1 - 0.24 11.9 0.9 0.39 11.2 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF202) DUF2391 PF09622.10 CDI87743.1 - 0.00052 19.4 2.4 0.016 14.6 0.8 2.6 2 0 0 2 2 2 1 Putative integral membrane protein (DUF2391) Cnd1 PF12717.7 CDI87743.1 - 0.0027 17.8 3.0 0.44 10.6 0.1 3.0 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 RAB3GAP2_N PF14655.6 CDI87743.1 - 0.0052 16.1 0.9 0.0052 16.1 0.9 3.4 3 0 0 3 3 3 1 Rab3 GTPase-activating protein regulatory subunit N-terminus RskA PF10099.9 CDI87743.1 - 0.054 13.8 47.8 1.8 8.9 0.2 4.6 2 1 1 4 4 4 0 Anti-sigma-K factor rskA Consortin_C PF15281.6 CDI87743.1 - 0.59 10.2 3.7 0.78 9.8 0.2 2.4 2 0 0 2 2 2 0 Consortin C-terminus Tic110 PF16940.5 CDI87743.1 - 1.8 6.9 13.5 0.017 13.6 0.9 2.2 2 0 0 2 2 2 0 Chloroplast envelope transporter Sec62 PF03839.16 CDI87743.1 - 7.1 6.1 11.3 25 4.3 4.9 3.3 2 1 0 2 2 2 0 Translocation protein Sec62 SPX PF03105.19 CDI87743.1 - 10 6.0 30.9 1.2e+04 -4.2 31.0 2.4 1 1 0 1 1 1 0 SPX domain SR-25 PF10500.9 CDI87744.1 - 0.0037 16.9 8.2 0.0037 16.9 8.2 5.0 6 1 0 6 6 6 1 Nuclear RNA-splicing-associated protein Guanylate_cyc PF00211.20 CDI87745.1 - 2.8e-17 62.9 1.2 4.9e-17 62.2 0.2 1.8 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Ion_trans PF00520.31 CDI87745.1 - 7.9e-07 28.6 5.5 7.9e-07 28.6 5.5 1.9 2 0 0 2 2 2 1 Ion transport protein PSII PF00421.19 CDI87745.1 - 0.068 11.8 2.4 0.12 11.0 2.1 1.6 1 1 0 1 1 1 0 Photosystem II protein DUF937 PF06078.11 CDI87747.1 - 0.0063 17.1 5.2 0.0081 16.8 5.2 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF937) SUIM_assoc PF16619.5 CDI87747.1 - 0.028 14.5 13.6 0.053 13.6 1.8 2.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 GvpL_GvpF PF06386.11 CDI87747.1 - 0.083 12.8 2.9 0.1 12.5 2.9 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Spt20 PF12090.8 CDI87747.1 - 1.5 8.4 11.2 1.9 8.1 11.2 1.2 1 0 0 1 1 1 0 Spt20 family RabGAP-TBC PF00566.18 CDI87748.1 - 2.4e-41 141.7 6.2 3.2e-41 141.4 6.2 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Na_H_Exchanger PF00999.21 CDI87749.1 - 1.2e-09 37.4 8.5 1.7e-09 37.0 8.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family SUIM_assoc PF16619.5 CDI87749.1 - 0.0054 16.8 1.7 0.0054 16.8 1.7 2.4 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Presenilin PF01080.17 CDI87749.1 - 0.024 13.4 0.8 0.038 12.8 0.8 1.4 1 0 0 1 1 1 0 Presenilin Dymeclin PF09742.9 CDI87749.1 - 0.025 13.0 1.2 0.033 12.6 1.2 1.1 1 0 0 1 1 1 0 Dyggve-Melchior-Clausen syndrome protein DUF3446 PF11928.8 CDI87749.1 - 2.7 8.3 8.6 7.3 7.0 8.6 1.7 1 0 0 1 1 1 0 Early growth response N-terminal domain VKG_Carbox PF05090.14 CDI87750.1 - 0.027 13.3 3.1 0.18 10.6 0.1 2.0 2 0 0 2 2 2 0 Vitamin K-dependent gamma-carboxylase AIF_C PF14721.6 CDI87750.1 - 0.045 14.1 0.5 0.045 14.1 0.5 2.7 2 1 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Ctr PF04145.15 CDI87750.1 - 0.14 12.8 5.4 2 9.0 0.8 2.5 2 0 0 2 2 2 0 Ctr copper transporter family Serinc PF03348.15 CDI87750.1 - 0.14 11.0 4.6 0.25 10.2 0.8 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) CLN3 PF02487.17 CDI87750.1 - 0.64 9.0 11.4 0.74 8.8 2.6 2.2 2 0 0 2 2 2 0 CLN3 protein CCSAP PF15748.5 CDI87750.1 - 1.4 9.1 18.4 0.63 10.2 5.2 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated CPSF100_C PF13299.6 CDI87750.1 - 1.4 9.0 12.3 0.23 11.6 0.9 2.5 2 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FAM60A PF15396.6 CDI87750.1 - 5 7.1 12.1 7.2 6.5 3.2 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Tubulin PF00091.25 CDI87751.1 - 2.3e-68 230.3 0.0 4.3e-68 229.4 0.0 1.4 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDI87751.1 - 2.4e-42 144.1 0.0 3.6e-42 143.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 CDI87751.1 - 0.00028 21.2 0.0 0.0006 20.1 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 CDI87751.1 - 0.0057 15.9 0.0 0.012 14.9 0.0 1.4 2 0 0 2 2 2 1 Tubulin like Tubulin_3 PF14881.6 CDI87751.1 - 0.0059 16.3 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain IF4E PF01652.18 CDI87753.1 - 1e-05 25.4 0.0 1.7e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E RskA PF10099.9 CDI87753.1 - 0.0024 18.2 6.1 0.0024 18.2 6.1 7.7 4 2 1 6 6 6 1 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI87753.1 - 0.0076 15.2 9.6 0.02 13.9 9.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Band_3_cyto PF07565.13 CDI87753.1 - 0.024 14.4 0.3 0.048 13.5 0.3 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Spt20 PF12090.8 CDI87753.1 - 0.17 11.5 16.9 0.36 10.4 16.9 1.5 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI87753.1 - 0.32 12.0 4.1 0.87 10.6 4.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) LPMO_10 PF03067.15 CDI87754.1 - 0.16 12.6 18.5 0.2 12.3 18.5 1.1 1 0 0 1 1 1 0 Lytic polysaccharide mono-oxygenase, cellulose-degrading SpoIIP PF07454.11 CDI87754.1 - 0.75 9.2 19.7 0.74 9.2 19.7 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF702 PF05142.12 CDI87754.1 - 0.91 10.0 16.9 1.1 9.7 16.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Folate_carrier PF01770.18 CDI87754.1 - 1 8.0 13.6 1.1 7.9 13.6 1.0 1 0 0 1 1 1 0 Reduced folate carrier G0-G1_switch_2 PF15103.6 CDI87754.1 - 1.3 9.5 11.9 1.6 9.2 11.9 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 Paf1 PF03985.13 CDI87754.1 - 1.5 7.8 20.3 1.3 7.9 20.3 1.0 1 0 0 1 1 1 0 Paf1 CPSF100_C PF13299.6 CDI87754.1 - 1.7 8.8 14.6 1.7 8.8 14.6 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DDHD PF02862.17 CDI87754.1 - 2.8 8.0 17.4 2.7 8.1 17.4 1.0 1 0 0 1 1 1 0 DDHD domain TMEM174 PF15029.6 CDI87754.1 - 3.5 7.3 9.8 3.6 7.2 9.8 1.1 1 0 0 1 1 1 0 Transmembrane protein 174 eIF-3_zeta PF05091.12 CDI87754.1 - 4 6.3 27.0 3.7 6.4 27.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) STAC2_u1 PF16664.5 CDI87754.1 - 4 7.9 14.4 4.2 7.8 14.4 1.1 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Rxt3 PF08642.10 CDI87754.1 - 4.1 8.2 10.2 5.2 7.9 10.2 1.4 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 SLC12 PF03522.15 CDI87754.1 - 4.3 6.3 17.7 4.1 6.3 17.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 AAA_23 PF13476.6 CDI87754.1 - 4.4 7.7 19.7 4.4 7.7 19.7 1.1 1 0 0 1 1 1 0 AAA domain Tim54 PF11711.8 CDI87754.1 - 4.9 5.8 17.8 4.8 5.8 17.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 CDI87754.1 - 5.3 6.8 20.1 5.3 6.8 20.1 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1764 PF08576.10 CDI87754.1 - 5.5 8.0 17.8 6.3 7.8 17.8 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) EIIBC-GUT_N PF03612.14 CDI87754.1 - 5.8 6.6 17.3 6.3 6.5 17.3 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus AIF_C PF14721.6 CDI87754.1 - 6.2 7.2 16.5 7 7.0 16.5 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Pal1 PF08316.11 CDI87754.1 - 6.3 7.6 10.8 6.6 7.5 10.8 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein FAM60A PF15396.6 CDI87754.1 - 6.6 6.7 14.7 6.5 6.7 14.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Band_3_cyto PF07565.13 CDI87754.1 - 7.5 6.3 18.5 7.4 6.3 18.5 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Presenilin PF01080.17 CDI87754.1 - 8 5.1 24.4 7.9 5.1 24.4 1.0 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 CDI87754.1 - 8.7 5.6 20.6 8.3 5.7 20.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sec62 PF03839.16 CDI87754.1 - 9.2 5.7 14.2 9.4 5.7 14.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Apt1 PF10351.9 CDI87755.1 - 0.073 11.9 6.6 0.084 11.7 6.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain GT87 PF09594.10 CDI87755.1 - 0.092 12.4 8.6 0.035 13.8 5.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase family 87 PPP4R2 PF09184.11 CDI87755.1 - 0.41 10.2 9.8 0.54 9.8 9.8 1.1 1 0 0 1 1 1 0 PPP4R2 DUF4834 PF16118.5 CDI87755.1 - 6.5 7.8 6.3 91 4.1 6.3 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) RVT_1 PF00078.27 CDI87756.1 - 0.0002 21.0 0.0 0.00044 19.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AHJR-like PF18743.1 CDI87757.1 - 0.39 10.3 2.3 1.8 8.2 0.7 2.3 1 1 1 2 2 2 0 REase_AHJR-like STOP PF05217.12 CDI87758.1 - 3.4e-05 24.1 6.2 0.00087 19.5 0.5 5.0 7 0 0 7 7 7 1 STOP protein RskA PF10099.9 CDI87759.1 - 5.4e-07 30.1 6.5 5.4e-07 30.1 6.5 3.6 1 1 2 3 3 3 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI87759.1 - 0.0013 18.4 31.5 0.0018 17.9 31.5 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Plexin_cytopl PF08337.12 CDI87759.1 - 0.19 10.4 9.0 0.91 8.1 0.0 2.1 2 0 0 2 2 2 0 Plexin cytoplasmic RasGAP domain SOBP PF15279.6 CDI87759.1 - 0.58 10.7 38.8 0.82 10.2 38.8 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein DUF3040 PF11239.8 CDI87759.1 - 0.59 10.4 4.9 7.9 6.8 0.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) MCM_bind PF09739.9 CDI87759.1 - 3.7 5.9 16.2 4.6 5.6 16.2 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Peptidase_S49_N PF08496.10 CDI87759.1 - 3.9 7.5 9.5 6.9 6.7 9.5 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SID-1_RNA_chan PF13965.6 CDI87759.1 - 6.3 5.1 5.7 8.5 4.7 5.7 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 LMBR1 PF04791.16 CDI87759.1 - 6.8 5.5 6.3 8.5 5.2 6.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein RskA PF10099.9 CDI87760.1 - 0.0072 16.6 14.1 0.0072 16.6 14.1 4.3 1 1 1 2 2 2 1 Anti-sigma-K factor rskA Aldo_ket_red PF00248.21 CDI87761.1 - 5.5e-09 35.6 0.0 0.00052 19.3 0.0 2.3 2 0 0 2 2 2 2 Aldo/keto reductase family SUIM_assoc PF16619.5 CDI87761.1 - 0.0029 17.6 1.8 0.0063 16.5 1.8 1.6 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Phostensin_N PF13916.6 CDI87761.1 - 1.9 8.9 5.6 22 5.5 1.7 2.8 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal Plasmodium_Vir PF05795.11 CDI87762.1 - 1.7e-05 24.5 3.5 2e-05 24.2 3.5 1.0 1 0 0 1 1 1 1 Plasmodium vivax Vir protein ALMT PF11744.8 CDI87762.1 - 7.1e-05 21.8 14.5 7.4e-05 21.8 14.5 1.0 1 0 0 1 1 1 1 Aluminium activated malate transporter CDC45 PF02724.14 CDI87762.1 - 0.00017 20.0 13.4 0.00019 19.9 13.4 1.0 1 0 0 1 1 1 1 CDC45-like protein DUF4746 PF15928.5 CDI87762.1 - 0.00029 20.4 9.4 0.00034 20.1 9.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) RR_TM4-6 PF06459.12 CDI87762.1 - 0.00042 20.3 22.9 0.0005 20.0 22.9 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 RIFIN PF02009.16 CDI87762.1 - 0.00058 19.9 9.6 0.00071 19.6 9.6 1.0 1 0 0 1 1 1 1 Rifin Zip PF02535.22 CDI87762.1 - 0.00079 18.7 19.5 0.00096 18.5 19.5 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF913 PF06025.12 CDI87762.1 - 0.001 18.1 10.2 0.0013 17.8 10.2 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) LAP1C PF05609.12 CDI87762.1 - 0.0029 16.8 21.8 0.0034 16.5 21.8 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) CbtA PF09490.10 CDI87762.1 - 0.0043 16.9 2.2 0.0043 16.9 2.2 2.0 1 1 1 2 2 1 1 Probable cobalt transporter subunit (CbtA) Tim54 PF11711.8 CDI87762.1 - 0.0076 15.1 16.2 0.0098 14.7 16.2 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 FAM60A PF15396.6 CDI87762.1 - 0.011 15.8 15.3 0.013 15.6 15.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Neur_chan_memb PF02932.16 CDI87762.1 - 0.012 15.7 17.1 0.016 15.3 17.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Suf PF05843.14 CDI87762.1 - 0.014 15.4 29.4 0.019 15.0 29.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) YscJ_FliF_C PF08345.11 CDI87762.1 - 0.018 15.4 21.4 0.023 15.0 21.4 1.1 1 0 0 1 1 1 0 Flagellar M-ring protein C-terminal HCO3_cotransp PF00955.21 CDI87762.1 - 0.019 13.8 10.0 0.024 13.5 10.0 1.1 1 0 0 1 1 1 0 HCO3- transporter family Orf78 PF06024.12 CDI87762.1 - 0.023 15.0 25.5 89 3.5 25.5 2.3 1 1 0 1 1 1 0 Orf78 (ac78) Sec62 PF03839.16 CDI87762.1 - 0.026 14.0 17.7 0.035 13.6 17.7 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Raftlin PF15250.6 CDI87762.1 - 0.029 13.1 17.7 0.032 13.0 17.7 1.0 1 0 0 1 1 1 0 Raftlin Patched PF02460.18 CDI87762.1 - 0.037 12.1 5.3 0.05 11.7 5.3 1.3 1 1 0 1 1 1 0 Patched family VIT1 PF01988.19 CDI87762.1 - 0.044 13.7 10.0 0.053 13.4 10.0 1.0 1 0 0 1 1 1 0 VIT family DUF5134 PF17197.4 CDI87762.1 - 0.058 13.3 0.1 0.099 12.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) DAG_kinase_N PF14513.6 CDI87762.1 - 0.059 13.6 21.5 0.078 13.2 21.5 1.1 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus DUF4337 PF14235.6 CDI87762.1 - 0.07 13.2 16.7 0.086 13.0 16.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) NPR3 PF03666.13 CDI87762.1 - 0.084 11.7 25.3 0.098 11.4 25.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SID-1_RNA_chan PF13965.6 CDI87762.1 - 0.14 10.6 14.1 0.17 10.3 14.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GET2 PF08690.10 CDI87762.1 - 0.14 11.8 21.9 0.2 11.3 21.9 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 FUSC PF04632.12 CDI87762.1 - 0.16 10.5 8.7 0.18 10.3 8.7 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Connexin PF00029.19 CDI87762.1 - 0.28 10.9 29.4 5.6 6.7 29.4 2.1 1 1 0 1 1 1 0 Connexin LMBR1 PF04791.16 CDI87762.1 - 0.28 10.1 14.1 0.37 9.6 14.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein MDFI PF15316.6 CDI87762.1 - 0.3 11.2 14.3 0.36 10.9 14.3 1.1 1 0 0 1 1 1 0 MyoD family inhibitor Vac7 PF12751.7 CDI87762.1 - 0.31 10.4 12.7 0.4 10.1 12.7 1.2 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 Membralin PF09746.9 CDI87762.1 - 0.33 10.0 16.6 0.4 9.7 16.6 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF2828 PF11443.8 CDI87762.1 - 0.39 8.7 23.0 0.46 8.5 23.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF1180 PF06679.12 CDI87762.1 - 0.5 10.8 4.6 0.69 10.3 4.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF2407_C PF13373.6 CDI87762.1 - 0.53 10.4 10.6 0.71 10.0 10.6 1.1 1 0 0 1 1 1 0 DUF2407 C-terminal domain Kei1 PF08552.11 CDI87762.1 - 0.56 10.0 20.2 2.6 7.9 20.2 1.8 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4448 PF14610.6 CDI87762.1 - 0.57 9.9 7.8 1.3 8.8 7.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) Otopetrin PF03189.13 CDI87762.1 - 0.59 8.9 15.2 0.95 8.2 15.2 1.4 1 0 0 1 1 1 0 Otopetrin SPX PF03105.19 CDI87762.1 - 0.68 9.8 19.9 0.78 9.6 19.9 1.1 1 0 0 1 1 1 0 SPX domain TMPIT PF07851.13 CDI87762.1 - 0.91 8.7 23.3 1.2 8.3 23.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein Ctr PF04145.15 CDI87762.1 - 0.94 10.1 23.5 8.2 7.0 23.5 1.9 1 1 0 1 1 1 0 Ctr copper transporter family Hamartin PF04388.12 CDI87762.1 - 0.99 8.0 23.2 1 7.9 23.2 1.0 1 0 0 1 1 1 0 Hamartin protein LicD PF04991.13 CDI87762.1 - 1.1 9.4 10.9 1.2 9.2 10.9 1.0 1 0 0 1 1 1 0 LicD family Dsh_C PF12316.8 CDI87762.1 - 1.1 9.6 19.9 1.3 9.3 19.9 1.0 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Pex14_N PF04695.13 CDI87762.1 - 1.5 9.5 40.6 9.3 6.9 40.6 1.8 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Endostatin PF06482.11 CDI87762.1 - 1.9 7.9 29.7 2.4 7.6 29.7 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SLC12 PF03522.15 CDI87762.1 - 2 7.4 29.8 2.4 7.1 29.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 WTX PF09422.10 CDI87762.1 - 2.8 6.9 19.9 3.2 6.7 19.9 1.0 1 0 0 1 1 1 0 WTX protein CAF1 PF04857.20 CDI87762.1 - 3.3 6.8 16.1 4.5 6.3 16.1 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease Calcyon PF06387.11 CDI87762.1 - 4.5 7.2 19.0 0.026 14.5 5.3 2.1 1 1 1 2 2 1 0 D1 dopamine receptor-interacting protein (calcyon) DUF3671 PF12420.8 CDI87762.1 - 4.6 7.4 7.3 7.9 6.6 7.3 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF2370 PF10176.9 CDI87762.1 - 4.6 6.8 16.9 11 5.6 16.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2370) DUF4407 PF14362.6 CDI87762.1 - 5.1 6.4 24.3 7.9 5.7 24.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2052 PF09747.9 CDI87762.1 - 5.7 7.0 29.2 7.1 6.7 29.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) MCM_bind PF09739.9 CDI87762.1 - 6.5 5.1 25.6 8 4.8 25.6 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CSG2 PF16965.5 CDI87762.1 - 8.2 5.3 20.4 47 2.7 20.4 1.8 1 1 0 1 1 1 0 Ceramide synthase regulator MRP-S26 PF14943.6 CDI87762.1 - 8.2 6.3 28.2 13 5.6 28.2 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 SAPS PF04499.15 CDI87762.1 - 8.4 5.1 24.7 10 4.7 24.7 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Renin_r PF07850.14 CDI87762.1 - 8.6 7.0 19.4 0.16 12.6 5.2 2.1 1 1 1 2 2 1 0 Renin receptor-like protein CemA PF03040.14 CDI87762.1 - 8.8 6.2 13.3 12 5.8 13.3 1.2 1 0 0 1 1 1 0 CemA family DUF2207 PF09972.9 CDI87762.1 - 9.2 4.9 12.2 53 2.4 12.2 1.9 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) KR PF08659.10 CDI87764.1 - 5.8e-52 176.2 0.0 2.1e-51 174.4 0.0 2.1 1 1 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 CDI87764.1 - 9.5e-42 143.6 3.7 7.9e-39 134.0 3.7 2.4 1 1 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CDI87764.1 - 1.8e-32 112.8 0.1 8.1e-32 110.6 0.1 2.0 1 1 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.25 CDI87764.1 - 4.1e-10 39.4 0.0 1.2e-09 38.0 0.0 1.8 1 0 0 1 1 1 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.22 CDI87764.1 - 2.5e-06 27.5 0.5 8.4e-06 25.8 0.5 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 CDI87764.1 - 5.6e-06 26.6 0.1 1.1e-05 25.6 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 CDI87764.1 - 1.2e-05 25.0 0.0 3.3e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KAsynt_C_assoc PF16197.5 CDI87764.1 - 0.00017 22.0 0.0 0.00055 20.4 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Velvet PF11754.8 CDI87765.1 - 0.009 16.0 12.6 0.0097 15.9 12.6 1.0 1 0 0 1 1 1 1 Velvet factor Presenilin PF01080.17 CDI87765.1 - 0.039 12.7 12.0 0.044 12.6 12.0 1.0 1 0 0 1 1 1 0 Presenilin TMEM51 PF15345.6 CDI87765.1 - 0.048 13.5 10.0 0.064 13.1 10.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 PA26 PF04636.13 CDI87765.1 - 0.089 11.7 9.6 0.1 11.5 9.6 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Peptidase_S64 PF08192.11 CDI87765.1 - 0.14 10.6 13.3 0.15 10.5 13.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 TFIIA PF03153.13 CDI87765.1 - 0.29 11.1 17.6 0.33 10.9 17.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit WBP-1 PF11669.8 CDI87765.1 - 0.34 11.6 10.9 4.5 8.0 5.7 2.1 1 1 1 2 2 2 0 WW domain-binding protein 1 DUF2448 PF10476.9 CDI87765.1 - 0.77 9.6 4.9 0.78 9.6 4.2 1.3 1 1 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) RAP1 PF07218.11 CDI87765.1 - 0.77 8.0 9.0 0.68 8.1 9.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) TAS2R PF05296.13 CDI87765.1 - 0.83 8.7 6.3 0.97 8.5 6.3 1.0 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) Corona_nucleoca PF00937.18 CDI87765.1 - 1.9 7.4 14.1 2.2 7.2 14.1 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Neur_chan_memb PF02932.16 CDI87765.1 - 2 8.4 8.5 2.6 8.0 8.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Comm PF15957.5 CDI87765.1 - 2.8 8.3 10.6 43 4.5 10.6 2.0 1 1 0 1 1 1 0 Commissureless SSP160 PF06933.11 CDI87765.1 - 2.9 6.0 14.9 3.2 5.8 14.9 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Menin PF05053.13 CDI87765.1 - 4.3 5.6 12.1 5.3 5.3 12.1 1.1 1 0 0 1 1 1 0 Menin Connexin PF00029.19 CDI87765.1 - 5.6 6.6 10.9 4.2e+02 0.5 10.9 2.0 1 1 0 1 1 1 0 Connexin DUF1117 PF06547.12 CDI87765.1 - 7.9 7.1 10.3 26 5.4 6.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) WRNPLPNID PF15017.6 CDI87765.1 - 9.4 7.2 15.7 1.3 9.9 5.8 2.2 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box SUIM_assoc PF16619.5 CDI87767.1 - 0.013 15.5 10.3 0.055 13.5 0.1 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Auxin_canalis PF05703.11 CDI87769.1 - 0.00082 19.4 11.1 0.001 19.1 11.1 1.1 1 0 0 1 1 1 1 Auxin canalisation Membralin PF09746.9 CDI87769.1 - 0.99 8.4 13.2 1.2 8.1 13.2 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF1345 PF07077.11 CDI87769.1 - 2.6 7.7 5.7 0.46 10.2 1.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) RR_TM4-6 PF06459.12 CDI87769.1 - 6.4 6.5 17.2 8.1 6.2 17.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RskA PF10099.9 CDI87769.1 - 7.2 6.9 33.8 5.7 7.2 23.7 2.5 1 1 1 2 2 2 0 Anti-sigma-K factor rskA SPX PF03105.19 CDI87771.1 - 0.02 14.8 63.3 0.17 11.8 6.8 3.0 3 0 0 3 3 3 0 SPX domain Apt1 PF10351.9 CDI87771.1 - 0.74 8.6 64.4 1.6 7.5 18.0 3.1 3 0 0 3 3 3 0 Golgi-body localisation protein domain Gti1_Pac2 PF09729.9 CDI87772.1 - 0.011 15.8 5.2 0.015 15.4 5.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family STAC2_u1 PF16664.5 CDI87772.1 - 0.048 14.1 6.6 0.058 13.8 6.6 1.2 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Presenilin PF01080.17 CDI87772.1 - 0.066 12.0 9.1 0.066 12.0 9.1 1.1 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI87772.1 - 0.085 12.8 27.4 0.099 12.6 27.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ric8 PF10165.9 CDI87772.1 - 0.097 11.7 8.8 0.11 11.5 8.8 1.0 1 0 0 1 1 1 0 Guanine nucleotide exchange factor synembryn Pex14_N PF04695.13 CDI87772.1 - 0.34 11.6 14.7 0.45 11.2 14.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Band_3_cyto PF07565.13 CDI87772.1 - 0.49 10.2 13.5 0.69 9.7 13.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2464 PF10240.9 CDI87772.1 - 0.82 9.2 6.0 0.89 9.1 6.0 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 Neur_chan_memb PF02932.16 CDI87772.1 - 2.2 8.3 8.2 2.9 7.9 8.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BAT2_N PF07001.11 CDI87772.1 - 3.1 8.2 15.6 14 6.1 15.6 1.8 1 1 0 1 1 1 0 BAT2 N-terminus PAT1 PF09770.9 CDI87772.1 - 4.6 5.4 22.6 5.2 5.2 22.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Kei1 PF08552.11 CDI87772.1 - 8.2 6.3 6.2 11 5.9 6.2 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 SpoIIIAH PF12685.7 CDI87773.1 - 0.011 15.6 8.1 0.011 15.6 8.1 3.4 3 0 0 3 3 3 0 SpoIIIAH-like protein Dynamin_N PF00350.23 CDI87773.1 - 0.018 15.1 4.9 0.047 13.8 1.6 2.3 2 0 0 2 2 2 0 Dynamin family DUF4746 PF15928.5 CDI87773.1 - 0.38 10.1 27.5 0.61 9.5 19.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) AAA_11 PF13086.6 CDI87773.1 - 0.53 10.0 24.8 0.86 9.3 17.0 2.4 2 0 0 2 2 2 0 AAA domain GAGA_bind PF06217.12 CDI87773.1 - 0.59 10.4 22.1 0.76 10.0 15.2 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family Exonuc_VII_L PF02601.15 CDI87773.1 - 1 8.8 27.5 2.8 7.5 17.7 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit SID-1_RNA_chan PF13965.6 CDI87773.1 - 3.7 5.8 8.7 1.5 7.1 4.6 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Caldesmon PF02029.15 CDI87773.1 - 4.1 6.0 36.9 0.88 8.3 26.3 2.2 2 0 0 2 2 2 0 Caldesmon Asp-B-Hydro_N PF05279.11 CDI87773.1 - 7.8 6.5 32.3 17 5.4 0.5 2.2 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region Nop53 PF07767.11 CDI87773.1 - 9.7 5.5 39.8 0.24 10.7 25.0 2.2 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) GAF PF01590.26 CDI87774.1 - 1.8e-13 51.3 0.0 5.5e-13 49.7 0.0 1.9 2 0 0 2 2 2 1 GAF domain GAF_2 PF13185.6 CDI87774.1 - 1.4e-09 38.3 0.0 5.1e-09 36.5 0.0 2.0 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 CDI87774.1 - 2.3e-09 37.7 0.0 5.9e-09 36.4 0.0 1.8 1 0 0 1 1 1 1 GAF domain DUF572 PF04502.13 CDI87774.1 - 0.099 12.2 12.7 0.055 13.1 6.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) SPX PF03105.19 CDI87774.1 - 0.19 11.6 14.0 0.34 10.8 6.2 2.2 2 0 0 2 2 2 0 SPX domain PA26 PF04636.13 CDI87774.1 - 0.25 10.2 5.4 2 7.3 4.5 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Suf PF05843.14 CDI87774.1 - 1.4 8.8 12.3 0.049 13.6 6.0 1.7 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Tmemb_cc2 PF10267.9 CDI87774.1 - 2.8 7.0 13.9 0.11 11.6 6.6 2.1 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein DUF755 PF05501.11 CDI87774.1 - 5 7.4 44.7 3.2 8.1 8.9 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF755) Band_3_cyto PF07565.13 CDI87774.1 - 7.1 6.3 7.6 1.5 8.6 3.3 2.0 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Amino_oxidase PF01593.24 CDI87775.1 - 2.8e-07 30.2 0.0 5.6e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase SUIM_assoc PF16619.5 CDI87775.1 - 0.0016 18.4 8.1 0.059 13.4 2.5 2.8 3 0 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI87775.1 - 0.93 9.1 13.7 0.14 11.7 2.8 2.4 2 0 0 2 2 2 0 Spt20 family DUF2722 PF10846.8 CDI87775.1 - 2.4 7.0 10.1 0.23 10.4 1.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) SNARE PF05739.19 CDI87776.1 - 0.042 13.9 0.1 0.13 12.3 0.1 1.7 1 0 0 1 1 1 0 SNARE domain MMS22L_N PF14910.6 CDI87777.1 - 0.18 10.2 0.0 0.24 9.8 0.0 1.1 1 0 0 1 1 1 0 S-phase genomic integrity recombination mediator, N-terminal Trp_oprn_chp PF09534.10 CDI87779.1 - 0.0009 19.1 35.1 0.051 13.4 12.2 2.5 2 0 0 2 2 2 2 Tryptophan-associated transmembrane protein (Trp_oprn_chp) EIF4E-T PF10477.9 CDI87779.1 - 0.04 12.8 32.0 0.046 12.6 32.0 1.3 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF2325 PF10087.9 CDI87779.1 - 0.12 12.5 1.1 0.29 11.3 1.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) Prothymosin PF03247.14 CDI87779.1 - 0.67 10.4 10.8 5.8 7.4 0.3 2.4 2 0 0 2 2 2 0 Prothymosin/parathymosin family DUF1644 PF07800.12 CDI87779.1 - 1.8 8.6 15.1 0.93 9.5 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) RskA PF10099.9 CDI87780.1 - 0.0044 17.4 20.7 0.0044 17.4 20.7 9.7 3 2 5 8 8 8 4 Anti-sigma-K factor rskA SMYLE_N PF18615.1 CDI87782.1 - 0.059 12.9 18.4 0.074 12.6 18.4 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Pox_RNA_Pol_19 PF05320.12 CDI87782.1 - 0.16 11.9 6.2 0.054 13.5 2.1 1.9 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Ribosomal_60s PF00428.19 CDI87782.1 - 0.21 12.2 10.6 0.35 11.5 10.6 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein HD_6 PF18019.1 CDI87782.1 - 0.32 11.1 20.4 0.4 10.8 20.4 1.1 1 0 0 1 1 1 0 HD domain BAF1_ABF1 PF04684.13 CDI87782.1 - 0.52 9.3 26.0 0.57 9.2 26.0 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor XRN1_D2_D3 PF18334.1 CDI87782.1 - 1.8 8.8 9.8 1.4 9.2 0.9 2.3 2 1 0 2 2 2 0 Exoribonuclease Xrn1 D2/D3 domain Sin_N PF04801.13 CDI87782.1 - 2.1 7.5 33.5 2.6 7.2 33.5 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region LAP1C PF05609.12 CDI87782.1 - 4.5 6.3 27.0 4.8 6.2 27.0 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RskA PF10099.9 CDI87783.1 - 3.7e-07 30.6 0.1 7.9e-07 29.5 0.1 1.7 1 1 0 1 1 1 1 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI87783.1 - 0.0052 15.8 14.1 0.0076 15.2 14.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF4484 PF14831.6 CDI87783.1 - 0.015 15.4 0.1 0.021 14.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) Spt20 PF12090.8 CDI87783.1 - 0.044 13.4 18.3 0.068 12.8 18.3 1.2 1 0 0 1 1 1 0 Spt20 family FSA_C PF10479.9 CDI87783.1 - 0.13 10.3 0.6 0.21 9.7 0.6 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus RRN9 PF10680.9 CDI87783.1 - 0.24 11.7 3.7 1.8 8.9 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor DUF4834 PF16118.5 CDI87783.1 - 0.49 11.4 4.0 0.94 10.5 4.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TFIIA PF03153.13 CDI87783.1 - 1 9.3 22.2 1.6 8.7 22.2 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI87783.1 - 1.4 7.5 18.1 0.017 13.8 10.0 1.7 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Androgen_recep PF02166.16 CDI87783.1 - 1.9 7.3 27.6 0.04 12.8 9.8 2.3 2 0 0 2 2 2 0 Androgen receptor DUF2489 PF10675.9 CDI87783.1 - 2.2 8.2 12.1 8.7 6.3 10.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) Hexokinase_2 PF03727.16 CDI87784.1 - 0.00058 19.4 2.9 0.14 11.5 2.9 2.3 1 1 0 1 1 1 1 Hexokinase VBS PF08913.10 CDI87784.1 - 0.013 15.9 0.1 0.58 10.6 0.0 2.6 1 1 1 2 2 2 0 Vinculin Binding Site TBCC_N PF16752.5 CDI87784.1 - 0.11 13.0 1.2 2.6 8.5 0.2 2.4 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain RIFIN PF02009.16 CDI87785.1 - 0.43 10.4 9.8 0.47 10.3 9.8 1.1 1 0 0 1 1 1 0 Rifin TFIIA PF03153.13 CDI87785.1 - 0.85 9.5 3.2 1.1 9.2 3.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CRT-like PF08627.10 CDI87786.1 - 6.4e-14 51.6 1.8 7.7e-14 51.4 1.8 1.1 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like Proteasome PF00227.26 CDI87789.1 - 7.5e-08 32.1 0.1 7.6e-06 25.5 0.0 2.1 1 1 1 2 2 2 2 Proteasome subunit Utp14 PF04615.13 CDI87790.1 - 1e-05 24.4 13.2 1e-05 24.4 13.2 3.7 3 1 0 3 3 3 1 Utp14 protein PPIP5K2_N PF18086.1 CDI87790.1 - 0.085 13.0 0.1 0.35 11.0 0.1 2.0 1 0 0 1 1 1 0 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain DUF5531 PF17671.1 CDI87792.1 - 0.049 13.5 0.5 0.06 13.2 0.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5531) PTPRCAP PF15713.5 CDI87793.1 - 4.6e-06 27.0 37.9 6.4e-06 26.5 6.7 3.3 2 1 1 3 3 3 2 Protein tyrosine phosphatase receptor type C-associated SR-25 PF10500.9 CDI87793.1 - 0.00024 20.8 9.3 0.00024 20.8 9.3 3.4 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein BPD_transp_2 PF02653.16 CDI87793.1 - 0.0015 17.8 1.7 0.87 8.7 0.1 3.0 2 1 0 3 3 3 2 Branched-chain amino acid transport system / permease component Spt20 PF12090.8 CDI87793.1 - 0.007 16.0 12.5 0.007 16.0 12.5 4.1 2 1 1 3 3 3 1 Spt20 family FmiP_Thoc5 PF09766.9 CDI87793.1 - 0.014 14.7 33.5 0.18 11.1 5.6 3.1 3 0 0 3 3 3 0 Fms-interacting protein/Thoc5 Scs3p PF10261.9 CDI87793.1 - 0.38 10.2 7.9 0.23 10.9 0.5 3.3 3 0 0 3 3 3 0 Inositol phospholipid synthesis and fat-storage-inducing TM TCP PF03634.13 CDI87793.1 - 2.2 8.9 44.7 0.39 11.3 9.0 3.3 3 0 0 3 3 3 0 TCP family transcription factor Spt20 PF12090.8 CDI87795.1 - 0.00067 19.3 4.1 0.00067 19.3 4.1 3.2 2 1 0 2 2 2 1 Spt20 family DUF2722 PF10846.8 CDI87795.1 - 0.011 14.7 1.7 0.011 14.7 1.7 3.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2722) SLC12 PF03522.15 CDI87795.1 - 0.033 13.2 28.0 0.11 11.5 25.2 2.0 2 0 0 2 2 2 0 Solute carrier family 12 Hamartin PF04388.12 CDI87795.1 - 1.7 7.2 24.2 2.6 6.6 24.2 1.3 1 0 0 1 1 1 0 Hamartin protein SID-1_RNA_chan PF13965.6 CDI87795.1 - 4.5 5.6 14.5 0.51 8.7 10.2 1.5 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 O-antigen_lig PF13425.6 CDI87795.1 - 5.9 5.6 16.2 0.98 8.1 12.5 1.5 2 0 0 2 2 2 0 O-antigen ligase like membrane protein Sin_N PF04801.13 CDI87795.1 - 8.7 5.4 50.8 8.3 5.5 0.6 2.3 2 0 0 2 2 2 0 Sin-like protein conserved region XPG_I PF00867.18 CDI87796.1 - 6.2e-23 81.0 0.1 9.7e-23 80.4 0.1 1.3 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 CDI87796.1 - 0.0003 20.4 0.0 0.00039 20.0 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing GIDA PF01134.22 CDI87796.1 - 0.14 11.2 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A RCR PF12273.8 CDI87797.1 - 0.0077 16.9 1.2 0.018 15.7 1.2 1.6 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red SpoIIP PF07454.11 CDI87797.1 - 0.043 13.3 1.6 0.058 12.8 1.6 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PAT1 PF09770.9 CDI87797.1 - 0.062 11.6 11.3 0.078 11.2 11.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 KAP_NTPase PF07693.14 CDI87797.1 - 0.085 12.1 1.2 0.16 11.2 1.2 1.4 1 0 0 1 1 1 0 KAP family P-loop domain NARP1 PF12569.8 CDI87797.1 - 0.13 11.1 6.6 0.62 8.9 4.9 2.0 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Lin-8 PF03353.15 CDI87797.1 - 0.23 11.0 13.9 0.053 13.1 10.0 1.7 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Tim54 PF11711.8 CDI87797.1 - 0.26 10.0 4.9 0.45 9.3 4.9 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TFIIA PF03153.13 CDI87797.1 - 3.7 7.4 37.1 11 5.9 37.1 1.7 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CDI87797.1 - 6.7 7.1 12.8 16 5.9 12.7 1.7 1 1 0 1 1 1 0 Enhancer of polycomb-like WBP-1 PF11669.8 CDI87797.1 - 7.3 7.3 13.0 21 5.8 6.6 2.6 1 1 1 2 2 2 0 WW domain-binding protein 1 PHC2_SAM_assoc PF16616.5 CDI87798.1 - 0.072 13.9 22.6 0.089 13.6 22.6 1.1 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Connexin PF00029.19 CDI87798.1 - 0.1 12.3 9.4 0.13 12.0 9.4 1.2 1 0 0 1 1 1 0 Connexin Draxin PF15550.6 CDI87798.1 - 0.14 12.0 13.3 0.16 11.8 13.3 1.0 1 0 0 1 1 1 0 Draxin DUF3807 PF12720.7 CDI87798.1 - 0.19 12.0 21.9 0.23 11.7 21.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) TFIIA PF03153.13 CDI87798.1 - 0.28 11.1 36.4 0.31 11.0 36.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Plasmodium_Vir PF05795.11 CDI87798.1 - 0.29 10.5 18.4 0.3 10.5 18.4 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein V_ATPase_I PF01496.19 CDI87798.1 - 0.3 9.0 17.4 0.31 8.9 17.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Apis_Csd PF11671.8 CDI87798.1 - 0.34 10.9 10.6 0.38 10.8 10.6 1.1 1 0 0 1 1 1 0 Complementary sex determiner protein SR-25 PF10500.9 CDI87798.1 - 0.38 10.3 24.5 0.5 9.9 24.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1168 PF06658.12 CDI87798.1 - 0.39 10.5 19.6 0.49 10.2 19.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) RR_TM4-6 PF06459.12 CDI87798.1 - 0.69 9.7 18.6 0.73 9.6 18.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Lin-8 PF03353.15 CDI87798.1 - 0.82 9.2 29.8 0.96 9.0 29.8 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2052 PF09747.9 CDI87798.1 - 0.87 9.7 17.4 0.98 9.5 17.4 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF1180 PF06679.12 CDI87798.1 - 0.92 9.9 14.3 1 9.7 14.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) PPL5 PF18168.1 CDI87798.1 - 1.4 8.2 13.0 1.6 8.0 13.0 1.1 1 0 0 1 1 1 0 Prim-pol family 5 eIF-3_zeta PF05091.12 CDI87798.1 - 1.4 7.8 20.2 1.6 7.6 20.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PepSY_TM PF03929.16 CDI87798.1 - 1.6 8.4 4.8 1.6 8.3 4.8 1.1 1 0 0 1 1 1 0 PepSY-associated TM region FAM76 PF16046.5 CDI87798.1 - 1.7 7.9 23.9 2.1 7.7 23.9 1.0 1 0 0 1 1 1 0 FAM76 protein GREB1 PF15782.5 CDI87798.1 - 1.8 5.6 28.1 1.9 5.5 28.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ALMT PF11744.8 CDI87798.1 - 2 7.1 22.5 2 7.1 22.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Miga PF10265.9 CDI87798.1 - 2 7.3 22.2 2.4 7.0 22.2 1.0 1 0 0 1 1 1 0 Mitoguardin NST1 PF13945.6 CDI87798.1 - 2.1 8.4 38.7 2.8 8.0 38.7 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF4746 PF15928.5 CDI87798.1 - 2.2 7.6 11.7 2.6 7.4 11.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Paf1 PF03985.13 CDI87798.1 - 2.3 7.1 20.7 2.8 6.9 20.7 1.1 1 0 0 1 1 1 0 Paf1 CCSAP PF15748.5 CDI87798.1 - 2.4 8.3 23.4 2.8 8.1 23.4 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4647 PF15504.6 CDI87798.1 - 2.9 6.9 22.6 3.4 6.7 22.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Macoilin PF09726.9 CDI87798.1 - 3.2 6.2 28.9 3.8 5.9 28.9 1.0 1 0 0 1 1 1 0 Macoilin family DUF1387 PF07139.11 CDI87798.1 - 3.4 7.3 26.2 4.1 7.1 26.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Presenilin PF01080.17 CDI87798.1 - 3.5 6.3 27.8 4.1 6.1 27.8 1.0 1 0 0 1 1 1 0 Presenilin Asp-B-Hydro_N PF05279.11 CDI87798.1 - 3.7 7.6 10.8 4.2 7.4 10.8 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Dicty_REP PF05086.12 CDI87798.1 - 3.8 5.4 24.3 4.1 5.3 24.3 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Tim54 PF11711.8 CDI87798.1 - 3.9 6.2 17.6 4.5 6.0 17.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4638 PF15472.6 CDI87798.1 - 4.1 7.1 16.2 4.9 6.8 16.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) SPX PF03105.19 CDI87798.1 - 4.4 7.1 28.1 4.5 7.1 28.1 1.0 1 0 0 1 1 1 0 SPX domain MCM_bind PF09739.9 CDI87798.1 - 4.4 5.6 22.0 5 5.4 22.0 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor NPR3 PF03666.13 CDI87798.1 - 4.8 5.9 24.8 5.3 5.7 24.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Sin_N PF04801.13 CDI87798.1 - 5.4 6.1 24.6 5.4 6.1 24.6 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region CDC45 PF02724.14 CDI87798.1 - 5.8 5.1 16.9 6.5 4.9 16.9 1.0 1 0 0 1 1 1 0 CDC45-like protein CLN3 PF02487.17 CDI87798.1 - 6 5.8 14.8 6.8 5.6 14.8 1.2 1 0 0 1 1 1 0 CLN3 protein Gti1_Pac2 PF09729.9 CDI87798.1 - 6.2 6.9 23.1 8.2 6.5 23.1 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Sec62 PF03839.16 CDI87798.1 - 6.2 6.3 15.2 7.1 6.1 15.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 SLC12 PF03522.15 CDI87798.1 - 6.4 5.7 25.4 7 5.6 25.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Mcm10 PF09332.11 CDI87798.1 - 7.4 5.9 26.7 8.9 5.6 26.7 1.0 1 0 0 1 1 1 0 Mcm10 replication factor UPF0560 PF10577.9 CDI87798.1 - 7.9 4.8 26.3 9.5 4.6 26.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 FAM60A PF15396.6 CDI87798.1 - 9.4 6.2 19.2 11 5.9 19.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF853 PF05872.12 CDI87798.1 - 9.7 4.6 13.4 11 4.4 13.4 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) PAT1 PF09770.9 CDI87798.1 - 9.7 4.3 28.5 11 4.1 28.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Gastrin PF00918.17 CDI87799.1 - 6.6 7.7 6.9 0.43 11.6 1.8 1.6 2 0 0 2 2 2 0 Gastrin/cholecystokinin family Activator_LAG-3 PF11498.8 CDI87800.1 - 0.0018 17.3 27.7 0.0018 17.3 27.7 2.3 2 0 0 2 2 2 1 Transcriptional activator LAG-3 Suf PF05843.14 CDI87800.1 - 1.2 9.0 21.9 0.91 9.4 15.6 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Med15 PF09606.10 CDI87800.1 - 2.1 6.9 39.9 0.66 8.6 31.1 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Glt_symporter PF03616.14 CDI87800.1 - 4 6.0 6.6 11 4.6 6.6 1.7 1 0 0 1 1 1 0 Sodium/glutamate symporter TERB2 PF15101.6 CDI87800.1 - 6.3 6.8 20.2 8.7 6.3 16.4 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Endomucin PF07010.12 CDI87800.1 - 9.9 6.1 29.0 3.2 7.6 5.4 2.2 2 0 0 2 2 2 0 Endomucin Nop14 PF04147.12 CDI87801.1 - 0.094 10.9 36.8 0.11 10.7 36.8 1.0 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 CDI87801.1 - 0.13 12.0 23.9 0.14 11.8 23.9 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein YbgS PF13985.6 CDI87801.1 - 0.19 12.0 5.5 0.23 11.7 5.5 1.2 1 0 0 1 1 1 0 YbgS-like protein BUD22 PF09073.10 CDI87801.1 - 0.3 10.4 30.1 0.35 10.2 30.1 1.1 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 CDI87801.1 - 0.37 9.5 12.6 0.4 9.4 12.6 1.0 1 0 0 1 1 1 0 Presenilin CDC27 PF09507.10 CDI87801.1 - 1.2 8.4 21.9 1.5 8.1 21.9 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF4045 PF13254.6 CDI87801.1 - 1.2 8.6 11.0 1.4 8.5 11.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) RR_TM4-6 PF06459.12 CDI87801.1 - 1.3 8.8 21.5 1.8 8.3 21.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 CDI87801.1 - 1.7 7.5 7.7 1.9 7.4 7.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SAPS PF04499.15 CDI87801.1 - 1.8 7.3 9.5 1.8 7.2 9.5 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein LAP1C PF05609.12 CDI87801.1 - 2.5 7.1 13.7 2.8 6.9 13.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CLN3 PF02487.17 CDI87801.1 - 2.6 7.0 3.0 2.8 6.9 3.0 1.2 1 0 0 1 1 1 0 CLN3 protein DDHD PF02862.17 CDI87801.1 - 2.7 8.1 4.3 3.7 7.7 4.3 1.3 1 0 0 1 1 1 0 DDHD domain Raftlin PF15250.6 CDI87801.1 - 3.2 6.4 12.0 3.6 6.2 12.0 1.0 1 0 0 1 1 1 0 Raftlin Tub_N PF16322.5 CDI87801.1 - 3.2 8.1 24.3 3.8 7.9 24.3 1.0 1 0 0 1 1 1 0 Tubby N-terminal Ureide_permease PF07168.11 CDI87801.1 - 5 5.8 4.7 6 5.5 4.7 1.3 1 0 0 1 1 1 0 Ureide permease CCSAP PF15748.5 CDI87801.1 - 5.3 7.1 15.2 6.2 6.9 15.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SDA1 PF05285.12 CDI87801.1 - 5.5 6.3 38.6 6.5 6.1 38.6 1.1 1 0 0 1 1 1 0 SDA1 SLC12 PF03522.15 CDI87801.1 - 7.4 5.5 6.3 8.4 5.3 6.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SpoIIP PF07454.11 CDI87801.1 - 8.3 5.8 15.9 13 5.2 15.9 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) VIR_N PF15912.5 CDI87801.1 - 8.4 5.9 18.0 9.8 5.7 18.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal PIG-S PF10510.9 CDI87802.1 - 7.8e-11 41.5 1.3 9.2e-06 24.8 0.0 3.1 4 0 0 4 4 4 2 Phosphatidylinositol-glycan biosynthesis class S protein B9-C2 PF07162.11 CDI87803.1 - 2.4e-05 24.6 0.0 3e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein PmbA_TldD PF01523.16 CDI87806.1 - 2.5 7.8 13.3 3.7 7.3 13.3 1.2 1 0 0 1 1 1 0 Putative modulator of DNA gyrase DEAD PF00270.29 CDI87807.1 - 2.6e-18 66.4 2.4 1.3e-17 64.1 2.4 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase RskA PF10099.9 CDI87807.1 - 0.0021 18.4 5.0 0.0021 18.4 5.0 3.2 3 1 0 3 3 3 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI87807.1 - 0.0068 16.0 52.0 0.1 12.2 18.5 3.1 2 1 0 3 3 3 1 Spt20 family DUF1635 PF07795.11 CDI87807.1 - 0.033 14.1 29.3 0.054 13.3 12.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Apt1 PF10351.9 CDI87807.1 - 0.058 12.2 17.1 0.11 11.3 1.1 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain RhlB PF12300.8 CDI87807.1 - 0.077 13.1 8.4 0.081 13.1 0.6 2.4 2 0 0 2 2 2 0 ATP-dependent RNA helicase RhlB SOG2 PF10428.9 CDI87807.1 - 0.097 11.9 24.0 0.59 9.3 5.3 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein Miga PF10265.9 CDI87807.1 - 0.12 11.4 17.7 0.45 9.4 3.7 2.0 2 0 0 2 2 2 0 Mitoguardin DUF966 PF06136.13 CDI87807.1 - 0.15 11.8 19.9 0.14 11.9 4.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF966) EPL1 PF10513.9 CDI87807.1 - 0.18 12.2 17.1 1.2 9.5 5.4 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like CDK2AP PF09806.9 CDI87807.1 - 0.3 11.1 37.2 0.43 10.6 15.0 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein DUF1645 PF07816.11 CDI87807.1 - 0.4 11.2 17.8 0.17 12.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) TMEM51 PF15345.6 CDI87807.1 - 0.5 10.2 16.2 0.12 12.1 2.2 2.4 2 0 0 2 2 2 0 Transmembrane protein 51 SLC12 PF03522.15 CDI87807.1 - 0.82 8.6 15.9 0.79 8.7 2.7 2.1 2 0 0 2 2 2 0 Solute carrier family 12 TERB2 PF15101.6 CDI87807.1 - 0.95 9.5 26.9 0.045 13.8 7.3 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 F-protein PF00469.20 CDI87807.1 - 1 8.9 7.6 2.2 7.8 0.6 2.3 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef Secretin_N_2 PF07655.13 CDI87807.1 - 1.4 9.5 27.0 2.1 9.0 15.4 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain UPF0524 PF15823.5 CDI87807.1 - 1.5 8.1 15.4 0.17 11.3 0.4 2.3 2 0 0 2 2 2 0 UPF0524 of C3orf70 ABC2_membrane_2 PF12679.7 CDI87807.1 - 1.8 7.8 4.8 2.1 7.6 1.5 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein GREB1 PF15782.5 CDI87807.1 - 2.1 5.4 25.2 0.21 8.6 4.5 2.1 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 CDI87807.1 - 2.5 8.1 17.0 1.2 9.1 1.6 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region MMR1 PF08505.10 CDI87807.1 - 2.8 8.2 28.1 0.3 11.4 6.4 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Roughex PF06020.11 CDI87807.1 - 3.3 6.7 21.9 0.42 9.7 9.0 2.2 2 0 0 2 2 2 0 Drosophila roughex protein DUF4746 PF15928.5 CDI87807.1 - 3.7 6.9 6.6 0.51 9.7 1.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) BORG_CEP PF14957.6 CDI87807.1 - 3.8 8.7 19.9 2.9 9.0 2.3 2.3 2 0 0 2 2 2 0 Cdc42 effector PAP1 PF08601.10 CDI87807.1 - 3.8 7.1 25.0 2.2 7.9 3.7 2.2 2 0 0 2 2 2 0 Transcription factor PAP1 Mem_trans PF03547.18 CDI87807.1 - 4 5.7 10.1 2.5 6.4 0.5 2.2 2 0 0 2 2 2 0 Membrane transport protein Presenilin PF01080.17 CDI87807.1 - 4.9 5.8 23.8 0.37 9.5 5.2 2.1 2 0 0 2 2 2 0 Presenilin Membralin PF09746.9 CDI87807.1 - 5.2 6.0 9.4 4.2 6.3 1.4 2.1 2 0 0 2 2 2 0 Tumour-associated protein AF-4 PF05110.13 CDI87807.1 - 5.8 4.9 35.4 0.44 8.6 6.0 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Connexin PF00029.19 CDI87807.1 - 7.1 6.3 9.8 0.35 10.6 0.7 2.2 2 0 0 2 2 2 0 Connexin FCP1_C PF09309.10 CDI87807.1 - 8.4 6.2 20.3 1.7 8.5 4.0 2.2 2 0 0 2 2 2 0 FCP1, C-terminal Ribosomal_60s PF00428.19 CDI87807.1 - 9.4 6.9 31.7 3.3 8.4 10.1 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein Lin-8 PF03353.15 CDI87807.1 - 9.9 5.6 31.3 3.4 7.2 11.3 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist BUD22 PF09073.10 CDI87808.1 - 2.1e-08 33.9 0.0 2.1e-08 33.9 0.0 3.0 1 1 0 3 3 3 1 BUD22 Sin_N PF04801.13 CDI87808.1 - 8.5e-07 28.5 10.9 8.5e-07 28.5 10.9 2.5 2 0 0 2 2 2 1 Sin-like protein conserved region SR-25 PF10500.9 CDI87808.1 - 0.00076 19.2 18.6 0.00076 19.2 18.6 4.8 4 0 0 4 4 4 3 Nuclear RNA-splicing-associated protein CLN3 PF02487.17 CDI87808.1 - 0.0074 15.4 0.9 0.0074 15.4 0.9 2.7 3 0 0 3 3 3 1 CLN3 protein NAM-associated PF14303.6 CDI87808.1 - 0.019 15.7 4.5 0.019 15.7 4.5 4.4 4 1 0 4 4 4 0 No apical meristem-associated C-terminal domain Myc_N PF01056.18 CDI87808.1 - 0.043 13.7 0.4 0.043 13.7 0.4 5.4 3 2 3 6 6 6 0 Myc amino-terminal region Zip PF02535.22 CDI87808.1 - 0.091 12.0 23.8 0.079 12.2 1.7 3.1 3 0 0 3 3 3 0 ZIP Zinc transporter GEMIN8 PF15348.6 CDI87808.1 - 2.1 8.6 47.4 0.3 11.4 16.3 3.7 4 0 0 4 4 4 0 Gemini of Cajal bodies-associated protein 8 AAA_23 PF13476.6 CDI87808.1 - 5.5 7.4 52.6 6.4 7.2 16.0 3.5 3 0 0 3 3 3 0 AAA domain DUF2722 PF10846.8 CDI87810.1 - 5.8e-06 25.5 4.4 5.8e-06 25.5 4.4 6.1 5 1 1 6 6 6 2 Protein of unknown function (DUF2722) PIP5K PF01504.18 CDI87810.1 - 0.00078 18.8 1.9 0.00078 18.8 1.9 4.1 3 1 0 3 3 3 1 Phosphatidylinositol-4-phosphate 5-Kinase FliD_N PF02465.18 CDI87810.1 - 0.01 16.5 11.1 0.01 16.5 11.1 8.2 6 3 1 7 7 7 0 Flagellar hook-associated protein 2 N-terminus DUF4050 PF13259.6 CDI87810.1 - 0.086 13.2 41.5 0.44 10.8 5.5 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF4050) DUF2062 PF09835.9 CDI87810.1 - 0.25 11.2 0.1 0.25 11.2 0.1 3.6 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2062) Tubulin PF00091.25 CDI87812.1 - 8.6e-41 140.3 0.0 1.4e-40 139.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDI87812.1 - 9.7e-13 48.4 0.6 4.3e-11 43.1 0.2 2.2 1 1 1 2 2 2 2 Tubulin C-terminal domain SARAF PF06682.12 CDI87813.1 - 0.00032 20.5 8.8 0.00032 20.5 8.8 3.7 2 2 1 3 3 3 1 SOCE-associated regulatory factor of calcium homoeostasis RskA PF10099.9 CDI87813.1 - 0.00048 20.5 16.8 0.00048 20.5 16.8 8.0 1 1 5 7 7 7 2 Anti-sigma-K factor rskA DUF1180 PF06679.12 CDI87813.1 - 0.0076 16.7 6.2 0.0076 16.7 6.2 6.9 1 1 5 6 6 6 1 Protein of unknown function (DUF1180) IMUP PF15761.5 CDI87814.1 - 0.03 15.0 20.1 0.03 15.0 20.1 5.3 1 1 5 6 6 6 0 Immortalisation up-regulated protein DUF5331 PF17265.2 CDI87816.1 - 0.063 13.0 0.6 0.13 12.0 0.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5331) Orf78 PF06024.12 CDI87817.1 - 0.004 17.4 5.0 0.004 17.4 5.0 4.5 1 1 2 3 3 3 1 Orf78 (ac78) Conotoxin PF02950.17 CDI87817.1 - 0.0074 17.3 1.6 0.0074 17.3 1.6 5.1 3 1 0 3 3 3 1 Conotoxin Tmemb_9 PF05434.11 CDI87817.1 - 0.015 15.2 1.1 0.015 15.2 1.1 4.0 2 1 1 3 3 3 0 TMEM9 TMEM154 PF15102.6 CDI87817.1 - 0.03 14.2 0.9 0.03 14.2 0.9 3.0 1 1 1 2 2 2 0 TMEM154 protein family DUF4834 PF16118.5 CDI87817.1 - 0.037 15.0 6.1 0.037 15.0 6.1 4.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 CDI87817.1 - 0.045 14.6 1.0 0.045 14.6 1.0 5.1 2 1 1 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain ATG16 PF08614.11 CDI87818.1 - 0.0045 17.2 10.5 0.0045 17.2 10.5 2.1 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Seryl_tRNA_N PF02403.22 CDI87818.1 - 0.0059 16.8 10.6 0.0059 16.8 10.6 2.9 1 1 2 3 3 3 1 Seryl-tRNA synthetase N-terminal domain DHR10 PF18595.1 CDI87818.1 - 0.032 14.3 9.5 0.032 14.3 9.5 3.4 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain TMF_TATA_bd PF12325.8 CDI87818.1 - 0.074 13.3 28.2 1.4 9.2 11.8 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Fez1 PF06818.15 CDI87818.1 - 0.11 12.9 24.9 0.16 12.4 24.9 1.3 1 0 0 1 1 1 0 Fez1 ING PF12998.7 CDI87818.1 - 0.19 12.3 16.9 0.15 12.7 7.2 2.4 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding NPV_P10 PF05531.12 CDI87818.1 - 0.43 11.1 11.8 1.7 9.2 2.1 3.1 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein GAS PF13851.6 CDI87818.1 - 0.48 9.7 32.9 0.071 12.5 25.9 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding RHD_DNA_bind PF00554.22 CDI87818.1 - 0.56 10.1 6.2 0.97 9.4 5.8 1.6 1 1 0 1 1 1 0 Rel homology DNA-binding domain FUSC PF04632.12 CDI87818.1 - 1.3 7.4 4.0 1.4 7.4 4.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family APG6_N PF17675.1 CDI87818.1 - 1.4 9.5 34.2 1.4 9.4 16.4 2.8 1 1 1 2 2 2 0 Apg6 coiled-coil region COG6 PF06419.11 CDI87818.1 - 1.4 7.0 20.0 0.026 12.8 8.8 2.3 2 1 1 3 3 3 0 Conserved oligomeric complex COG6 COG2 PF06148.11 CDI87818.1 - 1.7 8.7 14.0 2.8 8.0 1.1 3.1 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.11 CDI87818.1 - 1.9 7.3 31.6 0.026 13.4 11.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein HisKA PF00512.25 CDI87818.1 - 2.2 8.4 6.1 16 5.7 0.2 2.5 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain V_ATPase_I PF01496.19 CDI87818.1 - 2.6 5.8 16.7 3.1 5.6 16.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.10 CDI87818.1 - 5 7.3 24.1 1.3 9.3 2.0 3.0 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 CDI87818.1 - 5.5 6.2 28.4 0.14 11.4 8.3 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF724 PF05266.14 CDI87818.1 - 6.1 6.6 26.8 2.4 7.9 8.7 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF724) UPF0242 PF06785.11 CDI87818.1 - 7.8 6.6 32.1 0.26 11.4 11.4 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Glyoxalase PF00903.25 CDI87819.1 - 9.7e-11 42.0 0.0 7.8e-08 32.6 0.0 3.0 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CDI87819.1 - 0.0017 18.6 0.0 0.14 12.5 0.0 2.5 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Bacteriocin_IIc PF10439.9 CDI87820.1 - 6.9 6.9 9.8 3.9 7.7 6.1 2.4 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Asp_protease_2 PF13650.6 CDI87821.1 - 8.2e-07 29.6 0.0 1.9e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI87821.1 - 6.9e-06 26.5 0.0 1.6e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVT_1 PF00078.27 CDI87821.1 - 3.3e-05 23.5 0.1 0.00077 19.0 0.0 2.2 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CDI87821.1 - 7.1e-05 22.8 0.1 0.00014 21.8 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF1758 PF05585.12 CDI87821.1 - 0.027 14.2 0.0 0.064 13.0 0.0 1.5 1 0 0 1 1 1 0 Putative peptidase (DUF1758) Asp_protease PF09668.10 CDI87821.1 - 0.04 13.7 0.0 0.21 11.4 0.0 2.0 2 0 0 2 2 2 0 Aspartyl protease RVP PF00077.20 CDI87821.1 - 0.15 12.4 0.0 0.71 10.2 0.0 2.2 2 0 0 2 2 2 0 Retroviral aspartyl protease SARAF PF06682.12 CDI87822.1 - 0.038 13.6 12.4 0.046 13.4 12.4 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis V_ATPase_I PF01496.19 CDI87822.1 - 0.039 11.9 13.6 0.053 11.5 13.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MMU163 PF17119.5 CDI87822.1 - 0.074 12.2 5.9 0.033 13.3 3.7 1.5 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis SLC12 PF03522.15 CDI87822.1 - 0.084 11.9 10.9 0.083 11.9 10.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI87822.1 - 0.14 10.3 12.5 0.14 10.3 12.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4551 PF15087.6 CDI87822.1 - 0.22 10.3 11.2 0.29 9.9 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Band_3_cyto PF07565.13 CDI87822.1 - 0.28 11.0 14.5 0.19 11.5 12.9 1.4 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF4746 PF15928.5 CDI87822.1 - 0.29 10.5 10.6 0.47 9.8 10.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CCSAP PF15748.5 CDI87822.1 - 0.96 9.6 19.7 1.3 9.1 19.7 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Lin-8 PF03353.15 CDI87822.1 - 1.3 8.6 20.8 1.6 8.2 20.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PAT1 PF09770.9 CDI87822.1 - 1.3 7.2 30.0 1.5 7.0 30.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MDM10 PF12519.8 CDI87822.1 - 2.6 6.8 8.2 2.7 6.8 8.2 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 5_nucleotid PF05761.14 CDI87822.1 - 3 6.7 12.3 3.9 6.3 12.3 1.1 1 0 0 1 1 1 0 5' nucleotidase family CLN3 PF02487.17 CDI87822.1 - 3 6.8 7.7 4.9 6.1 7.7 1.4 1 0 0 1 1 1 0 CLN3 protein Connexin PF00029.19 CDI87822.1 - 3.4 7.4 9.1 6.4 6.5 9.1 1.4 1 0 0 1 1 1 0 Connexin DUF3381 PF11861.8 CDI87822.1 - 3.6 7.4 22.3 6 6.6 22.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) GREB1 PF15782.5 CDI87822.1 - 3.7 4.6 15.2 3.7 4.5 15.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Membralin PF09746.9 CDI87822.1 - 3.8 6.4 7.3 4.8 6.1 7.3 1.1 1 0 0 1 1 1 0 Tumour-associated protein ALMT PF11744.8 CDI87822.1 - 7.1 5.3 10.2 8.7 5.1 10.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Paf1 PF03985.13 CDI87822.1 - 8.2 5.3 20.6 13 4.7 20.6 1.2 1 0 0 1 1 1 0 Paf1 Med15 PF09606.10 CDI87823.1 - 3.4 6.2 15.2 3.5 6.2 15.2 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal MGTL PF17059.5 CDI87824.1 - 0.14 12.0 1.6 19 5.3 0.1 3.6 3 0 0 3 3 3 0 MgtA leader peptide G-gamma PF00631.22 CDI87824.1 - 0.22 11.6 7.3 1.4 8.9 0.4 2.9 3 0 0 3 3 3 0 GGL domain GCFC PF07842.12 CDI87825.1 - 6.8e-18 65.2 43.5 2.7e-16 60.0 19.6 4.9 3 2 2 5 5 5 2 GC-rich sequence DNA-binding factor-like protein RskA PF10099.9 CDI87825.1 - 1.3e-05 25.5 0.1 1.3e-05 25.5 0.1 7.2 3 2 4 7 7 7 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI87825.1 - 0.0049 16.5 12.4 0.0049 16.5 12.4 7.2 4 2 0 5 5 5 2 Spt20 family Mucin PF01456.17 CDI87825.1 - 0.0096 15.9 4.1 0.0096 15.9 4.1 4.4 4 1 0 4 4 4 1 Mucin-like glycoprotein DUF5449 PF17528.2 CDI87825.1 - 0.037 13.8 0.2 1.1 9.0 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5449) Utp14 PF04615.13 CDI87825.1 - 3.5 6.1 38.0 0.3 9.6 20.9 2.6 2 1 0 2 2 2 0 Utp14 protein Ribosomal_L13 PF00572.18 CDI87826.1 - 7.5e-05 23.0 0.8 0.011 16.0 0.1 2.9 2 1 0 2 2 2 1 Ribosomal protein L13 RskA PF10099.9 CDI87827.1 - 0.00024 21.4 34.3 0.00036 20.9 34.3 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI87827.1 - 0.0042 16.1 28.5 0.0045 16.0 28.5 1.1 1 0 0 1 1 1 1 Transcriptional activator LAG-3 CD20 PF04103.15 CDI87827.1 - 0.018 15.1 0.0 0.024 14.7 0.0 1.2 1 0 0 1 1 1 0 CD20-like family FHIPEP PF00771.20 CDI87827.1 - 0.042 12.3 9.5 0.043 12.3 9.5 1.1 1 0 0 1 1 1 0 FHIPEP family GBP_C PF02841.14 CDI87827.1 - 0.043 13.2 18.1 0.051 13.0 18.1 1.0 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain FAM60A PF15396.6 CDI87827.1 - 0.075 13.0 4.5 0.079 13.0 4.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Suf PF05843.14 CDI87827.1 - 0.091 12.7 13.9 0.099 12.6 13.9 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) ADP_ribosyl_GH PF03747.14 CDI87827.1 - 0.098 12.4 13.6 0.11 12.2 13.6 1.0 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase Bac_luciferase PF00296.20 CDI87827.1 - 0.13 11.6 15.1 0.15 11.5 15.1 1.0 1 0 0 1 1 1 0 Luciferase-like monooxygenase PigN PF04987.14 CDI87827.1 - 0.18 10.7 2.8 0.16 10.8 2.8 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) FAM199X PF15814.5 CDI87827.1 - 0.21 10.6 11.8 0.24 10.4 11.8 1.0 1 0 0 1 1 1 0 Protein family FAM199X EIF4E-T PF10477.9 CDI87827.1 - 0.24 10.2 14.0 0.24 10.2 14.0 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E SMYLE_N PF18615.1 CDI87827.1 - 0.26 10.8 9.0 0.3 10.6 9.0 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain TFIIA PF03153.13 CDI87827.1 - 0.34 10.9 36.3 0.4 10.6 36.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EOS1 PF12326.8 CDI87827.1 - 0.43 10.5 2.7 0.44 10.5 2.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein DcuA_DcuB PF03605.14 CDI87827.1 - 0.45 9.4 9.7 0.51 9.2 9.7 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter 2HCT PF03390.15 CDI87827.1 - 0.55 8.8 5.1 0.57 8.7 5.1 1.1 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family eIF-3_zeta PF05091.12 CDI87827.1 - 0.55 9.1 12.2 0.58 9.1 12.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AAA_23 PF13476.6 CDI87827.1 - 0.58 10.6 11.0 0.61 10.6 11.0 1.1 1 0 0 1 1 1 0 AAA domain TERB2 PF15101.6 CDI87827.1 - 0.64 10.0 12.1 0.71 9.9 12.1 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Dehydrin PF00257.19 CDI87827.1 - 0.78 10.3 12.8 1.1 9.8 12.8 1.3 1 0 0 1 1 1 0 Dehydrin Nop53 PF07767.11 CDI87827.1 - 0.82 9.0 13.4 0.89 8.9 13.4 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Med15 PF09606.10 CDI87827.1 - 0.83 8.3 27.9 1.2 7.8 27.9 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Mss4 PF04421.13 CDI87827.1 - 0.85 9.8 5.4 1.3 9.2 5.4 1.2 1 0 0 1 1 1 0 Mss4 protein DUF2232 PF09991.9 CDI87827.1 - 1.1 8.4 7.4 1.3 8.2 7.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) MCU PF04678.13 CDI87827.1 - 1.1 9.4 9.5 1.1 9.3 9.5 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF4667 PF15700.5 CDI87827.1 - 1.1 9.3 9.2 1.3 9.1 9.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) Tim54 PF11711.8 CDI87827.1 - 1.2 7.9 8.1 1.3 7.7 8.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF1980 PF09323.10 CDI87827.1 - 1.4 8.8 5.7 1.6 8.6 5.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Baculo_PP31 PF05311.11 CDI87827.1 - 1.5 8.3 8.3 1.5 8.2 8.3 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) OmpH PF03938.14 CDI87827.1 - 1.5 9.1 30.3 1.9 8.8 30.3 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) RXLR PF16810.5 CDI87827.1 - 1.6 9.2 19.4 1.5 9.2 6.5 2.0 1 1 1 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity Neur_chan_memb PF02932.16 CDI87827.1 - 1.7 8.7 5.3 1.8 8.6 5.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LMBR1 PF04791.16 CDI87827.1 - 2 7.3 5.0 2 7.2 5.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein CBP_BcsG PF11658.8 CDI87827.1 - 2.1 6.7 13.6 2.2 6.6 13.6 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DDHD PF02862.17 CDI87827.1 - 2.1 8.4 10.3 2.5 8.2 10.3 1.1 1 0 0 1 1 1 0 DDHD domain FliP PF00813.20 CDI87827.1 - 2.5 8.0 6.1 2.7 7.8 6.1 1.1 1 0 0 1 1 1 0 FliP family Hydin_ADK PF17213.3 CDI87827.1 - 2.5 8.3 14.7 3 8.1 14.7 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Presenilin PF01080.17 CDI87827.1 - 2.5 6.8 14.0 2.9 6.6 14.0 1.0 1 0 0 1 1 1 0 Presenilin Coilin_N PF15862.5 CDI87827.1 - 2.6 7.8 11.7 3.1 7.6 11.7 1.2 1 0 0 1 1 1 0 Coilin N-terminus DcuC PF03606.15 CDI87827.1 - 2.8 6.3 8.9 3.2 6.1 8.9 1.0 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier Serinc PF03348.15 CDI87827.1 - 2.9 6.7 7.0 3.2 6.6 7.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4407 PF14362.6 CDI87827.1 - 3 7.1 27.5 3.6 6.8 27.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2298 PF10060.9 CDI87827.1 - 3.3 6.3 9.2 3.7 6.2 9.2 1.0 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) Peptidase_S15 PF02129.18 CDI87827.1 - 3.4 7.2 13.7 4 6.9 13.7 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Mcm10 PF09332.11 CDI87827.1 - 3.5 7.0 14.7 3.9 6.8 14.7 1.1 1 0 0 1 1 1 0 Mcm10 replication factor DivIC PF04977.15 CDI87827.1 - 3.7 7.4 19.9 6.8 6.5 19.9 1.5 1 0 0 1 1 1 0 Septum formation initiator PAT1 PF09770.9 CDI87827.1 - 3.7 5.7 22.2 4.2 5.5 22.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RR_TM4-6 PF06459.12 CDI87827.1 - 5.5 6.7 11.9 6.5 6.5 11.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Aminotran_1_2 PF00155.21 CDI87827.1 - 8.7 5.4 14.0 11 5.0 14.0 1.3 1 1 0 1 1 1 0 Aminotransferase class I and II DUF4611 PF15387.6 CDI87828.1 - 0.0018 18.4 0.9 0.0031 17.7 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) Spt20 PF12090.8 CDI87828.1 - 0.0072 16.0 7.9 0.0085 15.7 7.9 1.1 1 0 0 1 1 1 1 Spt20 family DUF2052 PF09747.9 CDI87828.1 - 0.031 14.4 4.1 0.036 14.2 4.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) FAM176 PF14851.6 CDI87828.1 - 0.048 13.3 0.5 0.07 12.8 0.5 1.2 1 0 0 1 1 1 0 FAM176 family DUF4064 PF13273.6 CDI87828.1 - 0.057 13.7 0.1 0.16 12.3 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) TFIIA PF03153.13 CDI87828.1 - 0.062 13.3 11.5 0.078 13.0 11.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CLN3 PF02487.17 CDI87828.1 - 0.17 10.9 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 CLN3 protein Hist_deacetyl PF00850.19 CDI87828.1 - 0.28 10.6 1.4 0.45 9.9 1.4 1.2 1 0 0 1 1 1 0 Histone deacetylase domain CSG2 PF16965.5 CDI87828.1 - 0.32 9.9 0.1 0.39 9.6 0.1 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator BAF1_ABF1 PF04684.13 CDI87828.1 - 0.37 9.8 5.2 0.55 9.2 5.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Med15 PF09606.10 CDI87828.1 - 0.69 8.5 18.8 0.92 8.1 18.8 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Sporozoite_P67 PF05642.11 CDI87828.1 - 1 7.4 13.3 1.4 6.9 13.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SUIM_assoc PF16619.5 CDI87828.1 - 1.5 8.9 15.9 0.19 11.8 11.4 1.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 ALMT PF11744.8 CDI87828.1 - 1.8 7.3 4.9 2.3 7.0 4.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 CDI87828.1 - 6.8 5.3 6.3 8.8 5.0 6.3 1.1 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CDI87828.1 - 9.4 7.3 10.6 27 5.8 10.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) BUD22 PF09073.10 CDI87829.1 - 2.3e-07 30.5 47.3 0.0015 17.9 7.3 2.7 2 1 0 2 2 2 2 BUD22 SR-25 PF10500.9 CDI87829.1 - 0.0012 18.5 8.2 0.0012 18.5 8.2 4.3 3 1 0 3 3 3 2 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.19 CDI87830.1 - 0.27 11.8 36.3 0.55 10.9 10.5 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein CBP_BcsG PF11658.8 CDI87837.1 - 5.5e-07 28.4 7.8 5.8e-07 28.3 7.8 1.1 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG O-antigen_lig PF13425.6 CDI87837.1 - 0.00026 19.9 6.2 0.00032 19.6 6.2 1.1 1 0 0 1 1 1 1 O-antigen ligase like membrane protein DDHD PF02862.17 CDI87837.1 - 0.0007 19.8 1.2 0.0007 19.8 1.2 1.1 1 0 0 1 1 1 1 DDHD domain YfhO PF09586.10 CDI87837.1 - 0.00081 17.8 11.5 0.0012 17.2 11.5 1.3 1 0 0 1 1 1 1 Bacterial membrane protein YfhO SpoIIIAH PF12685.7 CDI87837.1 - 0.00084 19.2 5.7 0.0014 18.5 5.7 1.4 1 0 0 1 1 1 1 SpoIIIAH-like protein Velvet PF11754.8 CDI87837.1 - 0.001 19.1 1.5 0.001 19.1 1.5 1.1 1 0 0 1 1 1 1 Velvet factor PIP5K PF01504.18 CDI87837.1 - 0.0011 18.2 1.1 0.0012 18.1 1.1 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Folate_carrier PF01770.18 CDI87837.1 - 0.0044 15.8 12.1 0.0054 15.5 12.1 1.2 1 0 0 1 1 1 1 Reduced folate carrier Coilin_N PF15862.5 CDI87837.1 - 0.0054 16.5 9.3 0.0097 15.7 9.3 1.5 1 0 0 1 1 1 1 Coilin N-terminus SpoIIP PF07454.11 CDI87837.1 - 0.007 15.9 10.5 0.0091 15.5 10.5 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) FAM176 PF14851.6 CDI87837.1 - 0.0092 15.6 6.0 0.0092 15.6 6.0 1.8 2 0 0 2 2 2 1 FAM176 family MMM1 PF10296.9 CDI87837.1 - 0.013 14.6 6.5 0.018 14.1 6.5 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 CobT PF06213.12 CDI87837.1 - 0.018 14.4 15.0 0.023 14.1 15.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Mem_trans PF03547.18 CDI87837.1 - 0.02 13.3 6.5 0.026 12.9 6.5 1.2 1 0 0 1 1 1 0 Membrane transport protein DUF2828 PF11443.8 CDI87837.1 - 0.021 13.0 15.4 0.027 12.6 15.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CitMHS PF03600.16 CDI87837.1 - 0.038 13.2 0.0 0.044 13.0 0.0 1.1 1 0 0 1 1 1 0 Citrate transporter NicO PF03824.16 CDI87837.1 - 0.042 13.2 12.0 0.063 12.6 12.0 1.3 1 1 0 1 1 1 0 High-affinity nickel-transport protein SID-1_RNA_chan PF13965.6 CDI87837.1 - 0.048 12.1 12.1 0.076 11.4 12.1 1.4 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 SARAF PF06682.12 CDI87837.1 - 0.073 12.7 7.7 0.019 14.7 4.8 1.4 2 0 0 2 2 1 0 SOCE-associated regulatory factor of calcium homoeostasis RIC3 PF15361.6 CDI87837.1 - 0.077 13.4 8.4 0.15 12.4 8.4 1.4 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Peptidase_M50B PF13398.6 CDI87837.1 - 0.084 12.5 9.1 0.1 12.2 9.1 1.1 1 0 0 1 1 1 0 Peptidase M50B-like RskA PF10099.9 CDI87837.1 - 0.088 13.1 3.2 0.16 12.3 3.3 1.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA PTPRCAP PF15713.5 CDI87837.1 - 0.095 13.0 13.1 0.13 12.6 13.1 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Herpes_LMP1 PF05297.11 CDI87837.1 - 0.096 11.9 11.9 0.12 11.5 11.9 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Gastrin PF00918.17 CDI87837.1 - 0.11 13.5 10.6 0.21 12.6 10.6 1.4 1 0 0 1 1 1 0 Gastrin/cholecystokinin family BORG_CEP PF14957.6 CDI87837.1 - 0.11 13.6 5.4 0.16 13.1 5.4 1.2 1 0 0 1 1 1 0 Cdc42 effector CPSF100_C PF13299.6 CDI87837.1 - 0.15 12.3 9.4 0.21 11.7 9.4 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal V_ATPase_I PF01496.19 CDI87837.1 - 0.18 9.7 28.1 0.3 9.0 28.1 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Folliculin PF11704.8 CDI87837.1 - 0.31 10.9 7.4 0.41 10.5 7.4 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Peptidase_S49_N PF08496.10 CDI87837.1 - 0.43 10.6 21.7 0.082 13.0 18.2 1.5 1 1 1 2 2 2 0 Peptidase family S49 N-terminal DUF4834 PF16118.5 CDI87837.1 - 0.51 11.3 26.7 9.9 7.2 26.7 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) CLN3 PF02487.17 CDI87837.1 - 0.54 9.2 21.4 0.08 12.0 17.1 1.6 1 1 1 2 2 2 0 CLN3 protein BPL_N PF09825.9 CDI87837.1 - 0.57 9.2 6.8 0.65 9.0 6.8 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Wzy_C PF04932.15 CDI87837.1 - 0.63 9.7 3.8 1.4 8.6 3.8 1.6 1 1 0 1 1 1 0 O-Antigen ligase TFIIA PF03153.13 CDI87837.1 - 0.73 9.8 30.3 0.91 9.5 30.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CDI87837.1 - 0.91 9.9 16.1 1.3 9.4 16.1 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF3810 PF12725.7 CDI87837.1 - 1 8.7 6.0 1.2 8.4 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) SelP_N PF04592.14 CDI87837.1 - 1 8.7 19.6 1.5 8.1 19.6 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region O-ag_pol_Wzy PF14296.6 CDI87837.1 - 1.1 7.8 9.2 0.017 13.8 2.5 1.3 2 0 0 2 2 1 0 O-antigen polysaccharide polymerase Wzy UPF0565 PF10561.9 CDI87837.1 - 1.2 8.3 10.9 1.7 7.8 10.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Afi1 PF07792.12 CDI87837.1 - 1.3 9.5 13.7 2.2 8.8 13.7 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Tim54 PF11711.8 CDI87837.1 - 1.6 7.4 16.1 2.1 7.1 16.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4131 PF13567.6 CDI87837.1 - 1.6 8.3 16.3 9.4 5.8 16.3 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) DUF2126 PF09899.9 CDI87837.1 - 1.7 6.6 12.0 2.2 6.2 12.0 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) OATP PF03137.20 CDI87837.1 - 1.8 6.7 13.1 0.017 13.4 5.0 1.6 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Endonuc_Holl PF10107.9 CDI87837.1 - 1.9 8.3 13.6 2.9 7.7 13.6 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase eIF-3_zeta PF05091.12 CDI87837.1 - 2.2 7.2 18.8 2.8 6.8 18.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ALMT PF11744.8 CDI87837.1 - 2.5 6.8 13.1 3.4 6.4 13.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter YABBY PF04690.13 CDI87837.1 - 2.6 8.6 13.8 3.8 8.1 13.8 1.2 1 0 0 1 1 1 0 YABBY protein DUF4746 PF15928.5 CDI87837.1 - 2.7 7.4 12.4 4.2 6.7 12.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RED_N PF07808.13 CDI87837.1 - 3 7.4 21.5 6 6.4 21.5 1.5 1 0 0 1 1 1 0 RED-like protein N-terminal region RR_TM4-6 PF06459.12 CDI87837.1 - 3.9 7.2 19.0 5.9 6.6 19.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Gti1_Pac2 PF09729.9 CDI87837.1 - 4.1 7.5 13.1 6.1 6.9 13.1 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Nucleoside_tran PF01733.18 CDI87837.1 - 4.9 6.5 11.3 7.3 5.9 10.8 1.5 1 1 1 2 2 2 0 Nucleoside transporter Bac_export_2 PF01312.19 CDI87837.1 - 5.3 6.1 17.4 7.2 5.7 17.4 1.3 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family TERB2 PF15101.6 CDI87837.1 - 6.2 6.8 21.5 7.8 6.5 21.5 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 tRNA_anti-like PF12869.7 CDI87837.1 - 6.3 6.4 14.5 45 3.6 14.5 2.4 1 1 0 1 1 1 0 tRNA_anti-like AIF_C PF14721.6 CDI87837.1 - 6.9 7.0 12.3 11 6.4 12.3 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Pex14_N PF04695.13 CDI87837.1 - 7 7.3 19.1 12 6.6 19.1 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3292 PF11696.8 CDI87837.1 - 7.1 4.9 15.3 11 4.3 15.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) 7tm_7 PF08395.12 CDI87837.1 - 8.3 5.5 28.6 12 5.0 28.6 1.4 1 1 0 1 1 1 0 7tm Chemosensory receptor Paf1 PF03985.13 CDI87837.1 - 8.3 5.3 20.9 12 4.8 20.9 1.2 1 0 0 1 1 1 0 Paf1 SLD3 PF08639.10 CDI87837.1 - 8.5 5.0 21.2 15 4.2 21.2 1.4 1 0 0 1 1 1 0 DNA replication regulator SLD3 Utp12 PF04003.12 CDI87838.1 - 3.1e-08 33.9 4.0 7.9e-08 32.6 4.0 1.8 1 0 0 1 1 1 1 Dip2/Utp12 Family SR-25 PF10500.9 CDI87838.1 - 0.00023 20.9 2.2 0.00023 20.9 2.2 7.5 6 1 1 7 7 7 4 Nuclear RNA-splicing-associated protein Peptidase_S41 PF03572.18 CDI87838.1 - 0.0027 17.3 1.9 0.021 14.4 0.1 2.9 3 0 0 3 3 3 1 Peptidase family S41 Pex14_N PF04695.13 CDI87839.1 - 0.00047 20.8 17.5 0.00049 20.8 17.5 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2076 PF09849.9 CDI87839.1 - 0.00099 19.2 25.6 0.0011 19.0 25.6 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) SpoIIP PF07454.11 CDI87839.1 - 0.0014 18.1 10.6 0.0015 18.1 10.6 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) CCDC53 PF10152.9 CDI87839.1 - 0.0031 17.9 10.8 0.0031 17.9 10.8 1.1 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex CPSF100_C PF13299.6 CDI87839.1 - 0.0039 17.4 8.9 0.0041 17.3 8.9 1.1 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal DUF5308 PF17233.2 CDI87839.1 - 0.0045 17.2 7.9 0.0045 17.2 7.9 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5308) Afi1 PF07792.12 CDI87839.1 - 0.0065 16.9 11.1 0.0072 16.8 11.1 1.1 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking RR_TM4-6 PF06459.12 CDI87839.1 - 0.0088 15.9 11.6 0.0088 15.9 11.6 1.0 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 NPR3 PF03666.13 CDI87839.1 - 0.011 14.6 12.4 0.011 14.6 12.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CTU2 PF10288.9 CDI87839.1 - 0.014 15.7 9.3 0.016 15.4 9.3 1.2 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Presenilin PF01080.17 CDI87839.1 - 0.014 14.2 15.9 0.015 14.1 15.9 1.0 1 0 0 1 1 1 0 Presenilin Peroxin-13_N PF04088.13 CDI87839.1 - 0.016 15.5 4.0 0.018 15.3 4.0 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Rxt3 PF08642.10 CDI87839.1 - 0.016 15.9 3.8 0.019 15.8 3.8 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 DDHD PF02862.17 CDI87839.1 - 0.017 15.3 10.5 0.016 15.4 10.5 1.1 1 0 0 1 1 1 0 DDHD domain Suf PF05843.14 CDI87839.1 - 0.019 15.0 18.0 0.021 14.8 18.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Orf78 PF06024.12 CDI87839.1 - 0.022 15.1 5.4 0.037 14.3 5.4 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Connexin PF00029.19 CDI87839.1 - 0.023 14.5 10.9 0.024 14.4 10.9 1.1 1 0 0 1 1 1 0 Connexin SLC12 PF03522.15 CDI87839.1 - 0.036 13.1 10.5 0.035 13.1 10.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 RNA_pol_Rpc4 PF05132.14 CDI87839.1 - 0.037 14.5 12.2 0.044 14.2 12.2 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Kei1 PF08552.11 CDI87839.1 - 0.043 13.7 8.4 0.053 13.4 8.4 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 CLN3 PF02487.17 CDI87839.1 - 0.045 12.8 7.9 0.047 12.7 7.9 1.0 1 0 0 1 1 1 0 CLN3 protein PH_4 PF15404.6 CDI87839.1 - 0.067 13.0 7.5 0.083 12.7 7.5 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain Velvet PF11754.8 CDI87839.1 - 0.075 13.0 13.6 0.081 12.9 13.6 1.1 1 0 0 1 1 1 0 Velvet factor Endostatin PF06482.11 CDI87839.1 - 0.075 12.5 12.8 0.085 12.3 12.8 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Gti1_Pac2 PF09729.9 CDI87839.1 - 0.084 13.0 10.8 0.094 12.8 10.8 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family FAM60A PF15396.6 CDI87839.1 - 0.09 12.8 10.2 0.095 12.7 10.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Paf1 PF03985.13 CDI87839.1 - 0.096 11.7 17.0 0.11 11.5 17.0 1.0 1 0 0 1 1 1 0 Paf1 Band_3_cyto PF07565.13 CDI87839.1 - 0.1 12.4 12.6 0.12 12.2 12.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain BORG_CEP PF14957.6 CDI87839.1 - 0.11 13.7 7.6 0.12 13.6 7.6 1.1 1 0 0 1 1 1 0 Cdc42 effector eIF-3_zeta PF05091.12 CDI87839.1 - 0.11 11.4 27.4 0.14 11.1 27.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI87839.1 - 0.15 12.1 38.8 0.15 12.0 38.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EOS1 PF12326.8 CDI87839.1 - 0.16 11.9 6.5 0.18 11.8 6.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein Tim54 PF11711.8 CDI87839.1 - 0.16 10.7 12.8 0.19 10.5 12.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AIF_C PF14721.6 CDI87839.1 - 0.18 12.2 11.8 0.24 11.8 11.8 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term SID-1_RNA_chan PF13965.6 CDI87839.1 - 0.21 10.0 5.6 0.2 10.1 5.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ALMT PF11744.8 CDI87839.1 - 0.21 10.4 9.8 0.21 10.4 9.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3408 PF11888.8 CDI87839.1 - 0.22 11.7 15.9 0.25 11.5 15.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) XRN_M PF17846.1 CDI87839.1 - 0.23 10.4 7.5 0.23 10.4 7.5 1.0 1 0 0 1 1 1 0 Xrn1 helical domain DUF4366 PF14283.6 CDI87839.1 - 0.31 11.1 7.3 0.45 10.5 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF1980 PF09323.10 CDI87839.1 - 0.34 10.8 11.4 0.39 10.6 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Consortin_C PF15281.6 CDI87839.1 - 0.34 10.9 6.0 0.49 10.4 6.0 1.3 1 0 0 1 1 1 0 Consortin C-terminus Membralin PF09746.9 CDI87839.1 - 0.38 9.8 7.7 0.38 9.7 7.7 1.0 1 0 0 1 1 1 0 Tumour-associated protein TERB2 PF15101.6 CDI87839.1 - 0.39 10.7 22.2 0.44 10.6 22.2 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 PIP5K PF01504.18 CDI87839.1 - 0.39 9.9 13.4 0.45 9.7 13.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2370 PF10176.9 CDI87839.1 - 0.44 10.2 4.9 0.48 10.0 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF4637 PF15470.6 CDI87839.1 - 0.46 10.2 10.9 0.59 9.8 10.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Peptidase_S64 PF08192.11 CDI87839.1 - 0.47 8.9 11.6 0.5 8.8 11.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 TFB6 PF17110.5 CDI87839.1 - 0.49 10.1 9.7 0.6 9.8 9.7 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Serinc PF03348.15 CDI87839.1 - 0.5 9.2 8.7 0.49 9.3 8.7 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Neur_chan_memb PF02932.16 CDI87839.1 - 0.52 10.3 11.4 0.53 10.3 11.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.6 CDI87839.1 - 0.55 9.5 20.7 0.62 9.4 20.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4159 PF13709.6 CDI87839.1 - 0.58 9.5 7.2 17 4.8 7.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4159) MMU163 PF17119.5 CDI87839.1 - 0.59 9.3 7.1 0.67 9.1 7.1 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis EIIBC-GUT_N PF03612.14 CDI87839.1 - 0.61 9.8 13.5 0.78 9.5 13.5 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus GREB1 PF15782.5 CDI87839.1 - 0.63 7.1 12.5 0.6 7.2 12.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PepSY_TM PF03929.16 CDI87839.1 - 0.64 9.6 6.8 0.64 9.6 6.8 1.2 1 0 0 1 1 1 0 PepSY-associated TM region AAA_23 PF13476.6 CDI87839.1 - 0.64 10.5 18.0 0.68 10.4 18.0 1.1 1 0 0 1 1 1 0 AAA domain Eapp_C PF10238.9 CDI87839.1 - 0.66 10.0 17.6 0.81 9.8 17.6 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein FAM176 PF14851.6 CDI87839.1 - 0.7 9.6 10.2 0.89 9.2 10.2 1.2 1 0 0 1 1 1 0 FAM176 family Baculo_PP31 PF05311.11 CDI87839.1 - 0.72 9.3 13.9 0.76 9.2 13.9 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Ureide_permease PF07168.11 CDI87839.1 - 0.79 8.4 9.5 0.88 8.3 9.5 1.0 1 0 0 1 1 1 0 Ureide permease EPL1 PF10513.9 CDI87839.1 - 0.79 10.1 16.4 1 9.7 16.4 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Ndc1_Nup PF09531.10 CDI87839.1 - 0.96 8.1 11.2 0.91 8.1 11.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DDRGK PF09756.9 CDI87839.1 - 1 8.9 26.5 1.2 8.7 26.5 1.1 1 0 0 1 1 1 0 DDRGK domain DUF3464 PF11947.8 CDI87839.1 - 1 9.1 17.2 1.3 8.7 17.2 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 F-protein PF00469.20 CDI87839.1 - 1.1 8.8 13.3 1.3 8.6 13.3 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Ctr PF04145.15 CDI87839.1 - 1.1 9.8 9.3 1.3 9.6 9.3 1.2 1 0 0 1 1 1 0 Ctr copper transporter family PAT1 PF09770.9 CDI87839.1 - 1.2 7.3 28.2 1.3 7.2 28.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 HCO3_cotransp PF00955.21 CDI87839.1 - 1.3 7.7 5.1 1.5 7.5 5.1 1.0 1 0 0 1 1 1 0 HCO3- transporter family CSG2 PF16965.5 CDI87839.1 - 1.3 7.9 8.9 1.4 7.7 8.9 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator CobT PF06213.12 CDI87839.1 - 1.4 8.3 27.5 1.7 7.9 27.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT V_ATPase_I PF01496.19 CDI87839.1 - 1.4 6.7 18.2 1.6 6.6 18.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pkinase_fungal PF17667.1 CDI87839.1 - 1.5 7.5 11.2 1.6 7.4 11.2 1.1 1 0 0 1 1 1 0 Fungal protein kinase DUF4228 PF14009.6 CDI87839.1 - 1.6 9.1 9.7 1.9 8.9 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) MAJIN PF15077.6 CDI87839.1 - 1.6 8.4 13.4 1.6 8.4 13.4 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Peptidase_S49_N PF08496.10 CDI87839.1 - 1.8 8.6 14.6 2.8 8.0 14.6 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Cellulose_synt PF03552.14 CDI87839.1 - 1.8 7.0 6.5 1.8 6.9 6.5 1.0 1 0 0 1 1 1 0 Cellulose synthase DUF2828 PF11443.8 CDI87839.1 - 1.8 6.5 16.7 1.8 6.6 16.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4638 PF15472.6 CDI87839.1 - 2.1 8.0 15.6 2.1 8.0 15.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF3306 PF11748.8 CDI87839.1 - 2.2 9.2 16.9 3 8.7 16.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) DUF3405 PF11885.8 CDI87839.1 - 2.2 6.8 17.5 2.4 6.7 17.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) Hid1 PF12722.7 CDI87839.1 - 2.3 6.3 15.1 2.5 6.1 15.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Paramyxo_ncap PF00973.19 CDI87839.1 - 2.3 7.1 10.6 2.3 7.1 10.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein YABBY PF04690.13 CDI87839.1 - 2.6 8.6 12.1 2.8 8.5 12.1 1.1 1 0 0 1 1 1 0 YABBY protein Zip PF02535.22 CDI87839.1 - 2.6 7.2 7.9 2.9 7.0 7.9 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1764 PF08576.10 CDI87839.1 - 2.6 9.0 15.8 3.4 8.6 15.8 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) NARP1 PF12569.8 CDI87839.1 - 2.6 6.8 18.7 3 6.6 18.7 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 MDM10 PF12519.8 CDI87839.1 - 2.7 6.8 13.9 3 6.6 13.9 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Sec62 PF03839.16 CDI87839.1 - 2.7 7.4 14.1 2.9 7.3 14.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Scs3p PF10261.9 CDI87839.1 - 2.8 7.4 5.3 3.2 7.2 5.3 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF5327 PF17261.2 CDI87839.1 - 2.8 8.7 24.2 4.3 8.1 24.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5327) MDM31_MDM32 PF08118.11 CDI87839.1 - 2.9 6.4 11.7 3.5 6.2 11.7 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins ORC_WH_C PF18137.1 CDI87839.1 - 2.9 7.9 15.4 4 7.5 15.4 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal DUF3043 PF11241.8 CDI87839.1 - 3.2 7.8 19.4 4.9 7.2 19.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) MMR1 PF08505.10 CDI87839.1 - 4.5 7.5 20.4 5.4 7.2 20.4 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF2126 PF09899.9 CDI87839.1 - 4.6 5.2 13.6 5.3 5.0 13.6 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) PIG-S PF10510.9 CDI87839.1 - 5 5.8 15.9 5.6 5.7 15.9 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein DUF4175 PF13779.6 CDI87839.1 - 5.5 4.8 45.0 6.1 4.6 45.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Folate_carrier PF01770.18 CDI87839.1 - 5.8 5.5 10.4 6.6 5.4 10.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier Folliculin PF11704.8 CDI87839.1 - 5.9 6.7 14.6 7.5 6.4 14.6 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF4770 PF15994.5 CDI87839.1 - 6.1 7.0 19.1 8.5 6.6 19.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF4746 PF15928.5 CDI87839.1 - 6.6 6.1 14.8 7.6 5.9 14.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PPL5 PF18168.1 CDI87839.1 - 6.6 5.9 13.1 7.7 5.7 13.1 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Peptidase_U57 PF05582.12 CDI87839.1 - 7.6 5.7 13.7 8 5.6 13.7 1.1 1 0 0 1 1 1 0 YabG peptidase U57 PBP1_TM PF14812.6 CDI87839.1 - 8.1 6.9 14.4 13 6.3 14.4 1.4 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TFIIF_alpha PF05793.12 CDI87840.1 - 9.3e-05 21.2 22.0 0.00012 20.9 22.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF755 PF05501.11 CDI87840.1 - 0.043 14.1 27.2 0.4 10.9 9.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF755) YL1 PF05764.13 CDI87840.1 - 0.07 13.2 24.8 0.095 12.8 24.8 1.1 1 0 0 1 1 1 0 YL1 nuclear protein BAF1_ABF1 PF04684.13 CDI87840.1 - 0.11 11.6 29.1 0.13 11.3 29.1 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Lin-8 PF03353.15 CDI87840.1 - 0.15 11.6 20.0 0.2 11.2 20.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Mucin PF01456.17 CDI87840.1 - 0.21 11.6 14.9 0.24 11.4 14.9 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF2457 PF10446.9 CDI87840.1 - 0.23 10.5 19.5 0.3 10.2 19.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 CDI87840.1 - 0.27 9.5 24.1 0.33 9.2 24.1 1.0 1 0 0 1 1 1 0 CDC45-like protein BSP_II PF05432.11 CDI87840.1 - 0.32 10.6 22.0 0.41 10.3 22.0 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DNA_pol_phi PF04931.13 CDI87840.1 - 0.57 8.2 16.4 0.63 8.1 16.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Utp14 PF04615.13 CDI87840.1 - 0.79 8.2 29.1 0.96 7.9 29.1 1.0 1 0 0 1 1 1 0 Utp14 protein Nop14 PF04147.12 CDI87840.1 - 1 7.5 21.5 1.2 7.2 21.5 1.1 1 0 0 1 1 1 0 Nop14-like family RLL PF10036.9 CDI87840.1 - 1.2 9.0 19.0 1.5 8.6 19.0 1.2 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein LTV PF04180.14 CDI87840.1 - 1.9 8.2 23.1 2.3 7.9 23.1 1.0 1 0 0 1 1 1 0 Low temperature viability protein SARAF PF06682.12 CDI87840.1 - 1.9 8.1 14.6 2.5 7.7 14.6 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis PI3K_1B_p101 PF10486.9 CDI87840.1 - 2.1 6.0 17.3 2.6 5.7 17.3 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Nop53 PF07767.11 CDI87840.1 - 2.3 7.5 29.8 2.7 7.3 29.8 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF5427 PF10310.9 CDI87840.1 - 2.3 7.1 27.8 2.9 6.8 27.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) FAM220 PF15487.6 CDI87840.1 - 2.5 7.7 16.3 3.2 7.3 16.3 1.1 1 0 0 1 1 1 0 FAM220 family Med19 PF10278.9 CDI87840.1 - 2.9 7.8 17.6 0.46 10.4 13.5 1.6 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Apt1 PF10351.9 CDI87840.1 - 3.1 6.5 19.0 4.1 6.2 19.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MMR1 PF08505.10 CDI87840.1 - 4.2 7.6 22.8 5.3 7.2 22.8 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Glyco_hydro_9 PF00759.19 CDI87840.1 - 4.8 6.5 15.2 5.7 6.2 15.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 DUF733 PF05306.11 CDI87840.1 - 6.6 7.1 18.6 3.9 7.8 16.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF733) TAF4 PF05236.14 CDI87840.1 - 8.3 6.1 32.2 27 4.4 32.2 1.6 1 1 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family NST1 PF13945.6 CDI87840.1 - 8.6 6.4 33.7 47 4.0 33.7 1.8 1 1 0 1 1 1 0 Salt tolerance down-regulator TFIIA PF03153.13 CDI87840.1 - 8.9 6.2 25.3 11 5.9 25.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DTHCT PF08070.11 CDI87840.1 - 8.9 7.1 27.3 10 6.9 5.0 2.1 1 1 1 2 2 2 0 DTHCT (NUC029) region SWI-SNF_Ssr4 PF08549.10 CDI87840.1 - 9 4.8 22.7 10 4.6 22.7 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Miff PF05644.11 CDI87840.1 - 9.5 5.8 15.5 14 5.2 15.5 1.2 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Mitofilin PF09731.9 CDI87840.1 - 9.5 4.9 30.1 11 4.7 30.1 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein PrpF PF04303.13 CDI87841.1 - 0.022 13.8 1.0 0.03 13.3 1.0 1.1 1 0 0 1 1 1 0 PrpF protein DUF3682 PF12446.8 CDI87841.1 - 0.024 15.1 12.1 0.024 15.1 12.1 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF3682) DUF4887 PF16228.5 CDI87841.1 - 0.041 14.1 32.0 0.02 15.0 22.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4887) RR_TM4-6 PF06459.12 CDI87841.1 - 0.61 9.9 13.4 1.1 9.0 13.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NST1 PF13945.6 CDI87841.1 - 1.4 9.0 26.8 0.45 10.6 18.5 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator GREB1 PF15782.5 CDI87841.1 - 5.8 3.9 23.6 7.2 3.6 23.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AAA_23 PF13476.6 CDI87841.1 - 9.4 6.7 14.9 0.13 12.8 5.6 2.1 2 0 0 2 2 2 0 AAA domain DUF3273 PF11677.8 CDI87842.1 - 1.8e-10 40.6 0.0 2.3e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) Adeno_PIX PF03955.14 CDI87842.1 - 0.042 14.0 0.9 0.065 13.4 0.9 1.2 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) DUF3138 PF11336.8 CDI87842.1 - 0.054 12.1 6.1 0.075 11.6 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Chorion_2 PF03964.15 CDI87842.1 - 0.1 13.4 4.4 0.18 12.7 4.4 1.3 1 0 0 1 1 1 0 Chorion family 2 RskA PF10099.9 CDI87842.1 - 1.7 8.9 11.8 4.9 7.4 11.9 1.6 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Ten_N PF06484.12 CDI87842.1 - 9.6 6.0 8.0 12 5.6 8.0 1.0 1 0 0 1 1 1 0 Teneurin Intracellular Region FKS1_dom1 PF14288.6 CDI87845.1 - 4.1e-14 53.0 5.5 2e-11 44.3 5.5 2.6 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Rad54_N PF08658.10 CDI87845.1 - 0.025 14.7 0.0 0.052 13.7 0.0 1.4 1 0 0 1 1 1 0 Rad54 N terminal PID_2 PF14719.6 CDI87845.1 - 0.1 12.5 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) DUF5040 PF16443.5 CDI87845.1 - 0.1 11.9 0.1 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5040) PSD2 PF07624.11 CDI87846.1 - 0.09 12.6 0.1 11 5.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1585) Spt20 PF12090.8 CDI87847.1 - 0.15 11.7 0.2 0.15 11.7 0.2 2.1 2 0 0 2 2 2 0 Spt20 family PH_4 PF15404.6 CDI87847.1 - 0.29 10.9 1.2 0.46 10.2 0.0 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain UCR_TM PF02921.14 CDI87847.1 - 3 8.4 6.8 6.3 7.4 0.1 2.8 3 0 0 3 3 3 0 Ubiquinol cytochrome reductase transmembrane region TFIIA PF03153.13 CDI87848.1 - 7.2e-05 23.0 18.4 7.9e-05 22.8 18.4 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI87848.1 - 0.0041 16.0 17.0 0.0047 15.7 17.0 1.0 1 0 0 1 1 1 1 Presenilin DivIC PF04977.15 CDI87848.1 - 0.0097 15.7 7.3 0.0097 15.7 7.3 2.2 2 0 0 2 2 2 1 Septum formation initiator Menin PF05053.13 CDI87848.1 - 0.011 14.2 8.5 0.012 14.1 8.5 1.0 1 0 0 1 1 1 0 Menin Nha1_C PF08619.10 CDI87848.1 - 0.032 13.5 25.9 0.04 13.2 25.9 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus CDC27 PF09507.10 CDI87848.1 - 0.042 13.2 18.1 0.045 13.1 18.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Mucin PF01456.17 CDI87848.1 - 0.071 13.1 4.8 0.085 12.8 4.8 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Calpain_inhib PF00748.19 CDI87848.1 - 0.11 13.0 14.6 0.15 12.5 14.6 1.2 1 0 0 1 1 1 0 Calpain inhibitor SLC12 PF03522.15 CDI87848.1 - 0.12 11.3 13.5 0.13 11.2 13.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 BORG_CEP PF14957.6 CDI87848.1 - 0.15 13.2 9.0 0.21 12.8 9.0 1.3 1 0 0 1 1 1 0 Cdc42 effector Tfb4 PF03850.14 CDI87848.1 - 0.18 11.3 4.4 0.2 11.1 4.4 1.1 1 0 0 1 1 1 0 Transcription factor Tfb4 MMR1 PF08505.10 CDI87848.1 - 0.19 12.0 15.3 0.21 11.8 15.3 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF3169 PF11368.8 CDI87848.1 - 0.22 11.0 4.3 0.37 10.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Ndc1_Nup PF09531.10 CDI87848.1 - 0.35 9.5 11.2 0.38 9.4 11.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NPR3 PF03666.13 CDI87848.1 - 0.37 9.5 12.5 0.45 9.3 12.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4407 PF14362.6 CDI87848.1 - 0.42 9.9 13.1 0.47 9.7 13.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ALMT PF11744.8 CDI87848.1 - 0.45 9.3 11.7 0.55 9.0 11.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SAGA-Tad1 PF12767.7 CDI87848.1 - 0.47 10.2 10.0 0.54 9.9 10.0 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit SAPS PF04499.15 CDI87848.1 - 0.49 9.1 14.8 0.58 8.9 14.8 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein FAM70 PF14967.6 CDI87848.1 - 0.53 9.7 1.8 0.62 9.5 1.8 1.1 1 0 0 1 1 1 0 FAM70 protein Hid1 PF12722.7 CDI87848.1 - 0.56 8.3 16.4 0.61 8.2 16.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CDI87848.1 - 0.6 7.2 9.7 0.62 7.1 9.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MTABC_N PF16185.5 CDI87848.1 - 0.67 9.4 4.7 0.24 10.9 1.0 1.9 2 0 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region DUF4551 PF15087.6 CDI87848.1 - 0.71 8.6 13.3 0.91 8.3 13.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) PBP1_TM PF14812.6 CDI87848.1 - 0.86 10.0 11.3 2.6 8.5 1.4 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PepSY_TM PF03929.16 CDI87848.1 - 0.99 9.0 3.9 1.1 8.8 3.9 1.2 1 0 0 1 1 1 0 PepSY-associated TM region PI3K_1B_p101 PF10486.9 CDI87848.1 - 1 7.1 14.5 1.2 6.9 14.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit FAM60A PF15396.6 CDI87848.1 - 1 9.3 11.5 1.5 8.8 11.5 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Raftlin PF15250.6 CDI87848.1 - 1 8.0 15.4 1.2 7.8 15.4 1.1 1 0 0 1 1 1 0 Raftlin Pap_E4 PF02711.14 CDI87848.1 - 1.1 10.3 15.2 0.45 11.5 11.1 2.0 1 1 1 2 2 2 0 E4 protein DUF4808 PF16066.5 CDI87848.1 - 1.1 9.8 4.7 1.7 9.2 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4808) Dicty_REP PF05086.12 CDI87848.1 - 1.2 7.0 12.0 1.5 6.7 12.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein BAT2_N PF07001.11 CDI87848.1 - 1.2 9.5 16.5 1.7 9.0 16.5 1.2 1 0 0 1 1 1 0 BAT2 N-terminus Membralin PF09746.9 CDI87848.1 - 1.5 7.7 9.1 1.7 7.6 9.1 1.1 1 0 0 1 1 1 0 Tumour-associated protein PMSI1 PF15322.6 CDI87848.1 - 1.6 8.1 13.1 2.4 7.6 13.1 1.3 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative PCEMA1 PF07418.11 CDI87848.1 - 1.7 8.1 15.3 2 7.9 15.3 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 SDA1 PF05285.12 CDI87848.1 - 1.8 7.9 25.5 2.7 7.3 25.5 1.3 1 0 0 1 1 1 0 SDA1 BSP_II PF05432.11 CDI87848.1 - 1.9 8.1 31.8 2.9 7.5 31.8 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Neur_chan_memb PF02932.16 CDI87848.1 - 1.9 8.5 8.8 2.6 8.1 8.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region XRN_M PF17846.1 CDI87848.1 - 2.3 7.1 15.3 2.8 6.8 15.3 1.1 1 0 0 1 1 1 0 Xrn1 helical domain PPP4R2 PF09184.11 CDI87848.1 - 2.4 7.7 19.0 3.7 7.1 19.0 1.4 1 0 0 1 1 1 0 PPP4R2 V_ATPase_I PF01496.19 CDI87848.1 - 2.7 5.8 19.1 6.8 4.5 18.8 1.7 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF966 PF06136.13 CDI87848.1 - 2.8 7.6 17.2 3.2 7.4 17.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TMEM51 PF15345.6 CDI87848.1 - 3.8 7.3 15.9 6.1 6.6 15.9 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 Smg8_Smg9 PF10220.9 CDI87848.1 - 3.9 5.6 15.2 4.6 5.4 15.2 1.0 1 0 0 1 1 1 0 Smg8_Smg9 CK1gamma_C PF12605.8 CDI87848.1 - 4.1 8.6 16.8 6 8.1 16.6 1.4 1 1 0 1 1 1 0 Casein kinase 1 gamma C terminal CAML PF14963.6 CDI87848.1 - 4.5 7.3 9.6 5.5 7.0 9.6 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand LicD PF04991.13 CDI87848.1 - 5.2 7.1 7.0 7.6 6.6 7.0 1.2 1 0 0 1 1 1 0 LicD family CLN3 PF02487.17 CDI87848.1 - 5.3 6.0 14.2 9.6 5.1 14.2 1.6 1 1 0 1 1 1 0 CLN3 protein Apt1 PF10351.9 CDI87848.1 - 7.1 5.4 14.5 7.9 5.2 14.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain eIF-3c_N PF05470.12 CDI87848.1 - 7.6 4.7 17.2 9.3 4.4 17.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus LAP1C PF05609.12 CDI87848.1 - 8.2 5.4 20.7 9.6 5.2 20.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Peptidase_S64 PF08192.11 CDI87848.1 - 8.8 4.7 13.3 10 4.5 13.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 MDM10 PF12519.8 CDI87848.1 - 8.8 5.1 15.9 10 4.8 15.9 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 XAP5 PF04921.14 CDI87848.1 - 9.8 5.9 19.2 13 5.5 19.2 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator Abhydrolase_9_N PF15420.6 CDI87850.1 - 0.0044 17.0 4.6 0.0044 17.0 4.6 1.4 2 0 0 2 2 2 1 Alpha/beta-hydrolase family N-terminus SID-1_RNA_chan PF13965.6 CDI87850.1 - 0.17 10.2 10.1 0.22 9.9 10.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Orf78 PF06024.12 CDI87850.1 - 0.19 12.1 0.2 0.19 12.1 0.2 3.2 2 1 1 3 3 3 0 Orf78 (ac78) O-antigen_lig PF13425.6 CDI87850.1 - 1.3 7.7 11.8 0.12 11.1 7.3 1.5 1 1 1 2 2 2 0 O-antigen ligase like membrane protein KASH PF10541.9 CDI87850.1 - 4.7 7.5 7.6 0.85 9.9 2.5 2.1 2 0 0 2 2 2 0 Nuclear envelope localisation domain DUF3357 PF11837.8 CDI87850.1 - 7.1 7.1 13.8 1.6 9.2 2.5 3.1 1 1 3 4 4 4 0 Domain of unknown function (DUF3357) RskA PF10099.9 CDI87851.1 - 0.00028 21.2 15.3 0.00028 21.2 15.3 5.4 2 2 2 4 4 4 1 Anti-sigma-K factor rskA Macoilin PF09726.9 CDI87851.1 - 0.0031 16.1 17.7 0.0031 16.1 17.7 3.4 3 1 0 4 4 4 1 Macoilin family Spt20 PF12090.8 CDI87851.1 - 0.0078 15.8 5.5 0.0078 15.8 5.5 4.2 3 1 0 3 3 3 2 Spt20 family NST1 PF13945.6 CDI87851.1 - 1.8 8.6 62.2 3.8 7.6 2.0 3.4 3 0 0 3 3 3 0 Salt tolerance down-regulator Sporozoite_P67 PF05642.11 CDI87851.1 - 6.9 4.6 43.8 3.7 5.5 12.9 2.3 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Exonuc_VII_L PF02601.15 CDI87852.1 - 0.79 9.2 21.2 1.4 8.4 19.6 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit DDHD PF02862.17 CDI87852.1 - 2 8.5 11.6 5.2 7.2 11.6 1.7 1 0 0 1 1 1 0 DDHD domain eIF-3_zeta PF05091.12 CDI87852.1 - 6.1 5.7 20.1 11 4.8 20.1 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM60A PF15396.6 CDI87852.1 - 8 6.4 10.1 15 5.5 10.1 1.4 1 0 0 1 1 1 0 Protein Family FAM60A RskA PF10099.9 CDI87853.1 - 0.018 15.4 20.5 0.018 15.4 20.5 5.1 2 2 2 4 4 4 0 Anti-sigma-K factor rskA IATP PF04568.12 CDI87853.1 - 0.02 15.3 0.8 0.02 15.3 0.8 3.1 2 1 1 3 3 3 0 Mitochondrial ATPase inhibitor, IATP Wound_ind PF08186.11 CDI87853.1 - 2.5 8.6 4.2 9.8 6.7 4.2 2.1 1 0 0 1 1 1 0 Wound-inducible basic protein family TFIIA PF03153.13 CDI87856.1 - 0.00063 19.9 34.8 0.0008 19.5 34.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit zf-ZPR1 PF03367.13 CDI87856.1 - 0.014 15.3 2.8 0.023 14.6 2.8 1.3 1 0 0 1 1 1 0 ZPR1 zinc-finger domain TMEM247 PF15444.6 CDI87856.1 - 0.058 13.4 6.5 0.1 12.7 6.5 1.4 1 0 0 1 1 1 0 Transmembrane protein 247 PepSY_TM_like_2 PF16357.5 CDI87856.1 - 0.063 13.3 6.5 0.099 12.6 6.5 1.3 1 0 0 1 1 1 0 Putative PepSY_TM-like CCDC14 PF15254.6 CDI87856.1 - 0.15 10.7 18.1 0.18 10.5 18.1 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 Activator_LAG-3 PF11498.8 CDI87856.1 - 0.17 10.8 36.3 0.23 10.4 36.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Hist_deacetyl PF00850.19 CDI87856.1 - 0.53 9.7 5.9 0.048 13.1 0.7 1.7 2 0 0 2 2 2 0 Histone deacetylase domain Exonuc_VII_L PF02601.15 CDI87856.1 - 0.53 9.8 16.3 0.7 9.4 16.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Med15 PF09606.10 CDI87856.1 - 0.74 8.4 32.1 0.96 8.1 32.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal MMR1 PF08505.10 CDI87856.1 - 1.2 9.4 13.6 1.6 9.0 13.6 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Peptidase_M3 PF01432.20 CDI87856.1 - 1.8 7.8 10.9 2.4 7.3 10.9 1.1 1 0 0 1 1 1 0 Peptidase family M3 PAT1 PF09770.9 CDI87856.1 - 2.2 6.4 24.6 2.7 6.2 24.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LMBR1 PF04791.16 CDI87856.1 - 2.9 6.7 3.4 3.1 6.6 3.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Paramyxo_ncap PF00973.19 CDI87856.1 - 3 6.7 9.6 3.6 6.4 9.6 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein FliP PF00813.20 CDI87856.1 - 3 7.7 4.1 4.1 7.2 4.1 1.2 1 0 0 1 1 1 0 FliP family TERB2 PF15101.6 CDI87856.1 - 4.4 7.3 12.7 7 6.6 12.7 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 LUC7 PF03194.15 CDI87857.1 - 1.6e-07 31.3 0.1 1.6e-07 31.3 0.1 3.6 1 1 0 2 2 2 1 LUC7 N_terminus DUF4080 PF13311.6 CDI87857.1 - 0.064 13.5 4.4 0.12 12.6 4.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4080) LCD1 PF09798.9 CDI87858.1 - 5 5.5 15.6 7 5.0 15.6 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein MRP-S26 PF14943.6 CDI87858.1 - 6.9 6.5 17.0 15 5.4 17.0 1.6 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 DUF3807 PF12720.7 CDI87860.1 - 2.7 8.2 21.3 3.5 7.9 21.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Raftlin PF15250.6 CDI87860.1 - 8.5 5.0 22.1 9.4 4.9 22.1 1.0 1 0 0 1 1 1 0 Raftlin COLFI PF01410.18 CDI87861.1 - 0.002 17.5 0.0 0.0042 16.4 0.0 1.5 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Fibrinogen_C PF00147.18 CDI87861.1 - 0.077 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Fibrinogen beta and gamma chains, C-terminal globular domain RskA PF10099.9 CDI87862.1 - 0.00042 20.7 24.2 0.00084 19.7 24.2 1.4 1 1 0 1 1 1 1 Anti-sigma-K factor rskA TfuA PF07812.12 CDI87862.1 - 0.0014 18.3 0.9 0.0014 18.3 0.9 1.4 1 1 0 1 1 1 1 TfuA-like protein eIF-3_zeta PF05091.12 CDI87862.1 - 0.0019 17.3 16.3 0.0019 17.2 16.3 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ThiD2 PF17792.1 CDI87862.1 - 0.0058 17.1 6.4 0.0099 16.3 6.4 1.3 1 0 0 1 1 1 1 ThiD2 family SprA-related PF12118.8 CDI87862.1 - 0.0077 15.4 30.3 0.01 15.0 30.3 1.2 1 0 0 1 1 1 1 SprA-related family Suf PF05843.14 CDI87862.1 - 0.0084 16.1 12.3 0.0089 16.0 12.3 1.3 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Presenilin PF01080.17 CDI87862.1 - 0.0091 14.8 12.8 0.0095 14.7 12.8 1.1 1 0 0 1 1 1 1 Presenilin MPM1 PF17234.2 CDI87862.1 - 0.01 16.1 10.8 0.014 15.7 10.8 1.2 1 0 0 1 1 1 1 Mitochondrial peculiar membrane protein 1 SLC12 PF03522.15 CDI87862.1 - 0.016 14.2 9.2 0.016 14.3 9.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 RIFIN PF02009.16 CDI87862.1 - 0.02 14.8 13.2 0.025 14.5 13.2 1.1 1 0 0 1 1 1 0 Rifin RR_TM4-6 PF06459.12 CDI87862.1 - 0.027 14.3 13.2 0.03 14.1 13.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SID-1_RNA_chan PF13965.6 CDI87862.1 - 0.027 12.9 2.2 0.029 12.8 2.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PAT1 PF09770.9 CDI87862.1 - 0.032 12.5 22.1 0.035 12.4 22.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 CDI87862.1 - 0.033 14.3 6.0 0.033 14.2 6.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Velvet PF11754.8 CDI87862.1 - 0.038 13.9 9.3 0.038 13.9 9.3 1.2 1 0 0 1 1 1 0 Velvet factor DDHD PF02862.17 CDI87862.1 - 0.052 13.7 11.5 0.059 13.5 11.5 1.2 1 0 0 1 1 1 0 DDHD domain EOS1 PF12326.8 CDI87862.1 - 0.057 13.4 4.4 0.059 13.3 4.4 1.2 1 0 0 1 1 1 0 N-glycosylation protein FAM91_C PF14648.6 CDI87862.1 - 0.076 11.8 9.3 0.095 11.5 9.3 1.0 1 0 0 1 1 1 0 FAM91 C-terminus DUF2072 PF09845.9 CDI87862.1 - 0.08 13.2 11.7 0.1 12.9 11.7 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein FAM60A PF15396.6 CDI87862.1 - 0.093 12.7 10.6 0.12 12.4 10.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CLN3 PF02487.17 CDI87862.1 - 0.1 11.6 9.1 0.13 11.3 9.1 1.1 1 0 0 1 1 1 0 CLN3 protein TERB2 PF15101.6 CDI87862.1 - 0.11 12.5 17.0 0.14 12.2 17.0 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Serinc PF03348.15 CDI87862.1 - 0.12 11.3 6.0 0.12 11.2 6.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF5523 PF17661.1 CDI87862.1 - 0.12 12.0 14.1 0.16 11.7 14.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF1980 PF09323.10 CDI87862.1 - 0.13 12.1 7.4 0.13 12.1 7.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF913 PF06025.12 CDI87862.1 - 0.23 10.4 6.7 0.23 10.4 6.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Peroxin-13_N PF04088.13 CDI87862.1 - 0.25 11.6 7.0 0.41 10.9 7.0 1.4 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF4820 PF16091.5 CDI87862.1 - 0.27 10.6 10.8 0.39 10.0 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Exonuc_VII_L PF02601.15 CDI87862.1 - 0.27 10.8 15.6 0.32 10.5 15.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit SpoVR PF04293.13 CDI87862.1 - 0.3 9.7 12.6 0.38 9.4 12.6 1.0 1 0 0 1 1 1 0 SpoVR like protein Baculo_PP31 PF05311.11 CDI87862.1 - 0.3 10.5 15.5 0.39 10.2 15.5 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Nop53 PF07767.11 CDI87862.1 - 0.55 9.6 20.0 0.67 9.3 20.0 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) HSNSD PF12062.8 CDI87862.1 - 0.55 8.9 9.0 0.68 8.6 9.0 1.1 1 0 0 1 1 1 0 heparan sulfate-N-deacetylase SpoIIP PF07454.11 CDI87862.1 - 0.62 9.5 18.9 0.8 9.1 18.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Rxt3 PF08642.10 CDI87862.1 - 0.62 10.8 6.9 1 10.2 6.9 1.3 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Ndc1_Nup PF09531.10 CDI87862.1 - 0.76 8.4 9.9 0.79 8.3 9.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup EFTUD2 PF16004.5 CDI87862.1 - 0.82 10.3 15.9 1.3 9.7 15.9 1.2 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Peptidase_S15 PF02129.18 CDI87862.1 - 0.92 9.0 14.9 1.3 8.5 14.9 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Tim54 PF11711.8 CDI87862.1 - 0.93 8.2 14.1 1.5 7.5 14.1 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TraT PF05818.12 CDI87862.1 - 0.93 9.1 19.5 1.2 8.8 19.5 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein EIIBC-GUT_N PF03612.14 CDI87862.1 - 0.95 9.2 15.1 1.7 8.4 15.1 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus RPA43_OB PF17875.1 CDI87862.1 - 1 10.0 10.8 0.95 10.1 9.4 1.7 2 0 0 2 2 1 0 RPA43 OB domain in RNA Pol I HGTP_anticodon2 PF12745.7 CDI87862.1 - 1.1 8.8 15.6 1.7 8.1 15.6 1.2 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs GREB1 PF15782.5 CDI87862.1 - 1.1 6.3 13.5 1.1 6.3 13.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LMBR1 PF04791.16 CDI87862.1 - 1.3 7.9 6.7 1.2 7.9 6.7 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein HABP4_PAI-RBP1 PF04774.15 CDI87862.1 - 1.4 9.8 0.0 1.4 9.8 0.0 2.1 1 1 1 2 2 1 0 Hyaluronan / mRNA binding family NARP1 PF12569.8 CDI87862.1 - 1.5 7.7 18.2 2 7.2 18.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 AAA_23 PF13476.6 CDI87862.1 - 1.5 9.3 21.1 1.9 9.0 21.1 1.1 1 0 0 1 1 1 0 AAA domain MDM31_MDM32 PF08118.11 CDI87862.1 - 1.5 7.4 11.4 2 7.0 11.4 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins FAM176 PF14851.6 CDI87862.1 - 1.7 8.3 8.3 2.5 7.7 8.3 1.2 1 0 0 1 1 1 0 FAM176 family GOLD_2 PF13897.6 CDI87862.1 - 1.9 9.0 4.0 2.7 8.5 4.0 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking REC114-like PF15165.6 CDI87862.1 - 2.1 8.1 19.0 3.1 7.5 19.0 1.2 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like DUF2828 PF11443.8 CDI87862.1 - 2.8 5.9 17.7 3.5 5.6 17.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Gti1_Pac2 PF09729.9 CDI87862.1 - 2.8 8.0 15.6 4.1 7.5 15.6 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Sec62 PF03839.16 CDI87862.1 - 2.9 7.3 12.5 3.9 6.9 12.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 PIP5K PF01504.18 CDI87862.1 - 3.1 6.9 14.3 4.4 6.4 14.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Connexin PF00029.19 CDI87862.1 - 3.6 7.3 14.8 4.6 6.9 14.8 1.1 1 0 0 1 1 1 0 Connexin Hydin_ADK PF17213.3 CDI87862.1 - 3.7 7.8 16.0 5.7 7.2 16.0 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF3276 PF11680.8 CDI87862.1 - 3.8 7.7 16.2 5.8 7.1 16.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) Pex14_N PF04695.13 CDI87862.1 - 4.2 8.0 34.2 0.2 12.3 22.5 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PPL5 PF18168.1 CDI87862.1 - 4.5 6.5 11.8 5.9 6.1 11.8 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Folliculin PF11704.8 CDI87862.1 - 4.5 7.1 13.6 6.5 6.6 13.6 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport RNA_pol_Rpc4 PF05132.14 CDI87862.1 - 4.6 7.7 16.7 1.2 9.6 11.9 1.9 2 0 0 2 2 2 0 RNA polymerase III RPC4 ALMT PF11744.8 CDI87862.1 - 4.9 5.9 12.9 6 5.6 12.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4638 PF15472.6 CDI87862.1 - 5 6.8 13.9 5.9 6.5 13.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) HCO3_cotransp PF00955.21 CDI87862.1 - 5.1 5.8 7.5 6.3 5.5 7.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family Hid1 PF12722.7 CDI87862.1 - 5.2 5.1 14.3 6.1 4.8 14.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein G0-G1_switch_2 PF15103.6 CDI87862.1 - 5.3 7.5 11.8 10 6.6 11.8 1.5 1 0 0 1 1 1 0 G0/G1 switch protein 2 DUF4746 PF15928.5 CDI87862.1 - 7.2 5.9 11.9 9.8 5.5 11.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) HNOBA PF07701.14 CDI87862.1 - 8.7 5.7 15.1 11 5.3 15.1 1.2 1 0 0 1 1 1 0 Heme NO binding associated MTP18 PF10558.9 CDI87862.1 - 9.6 6.1 7.9 17 5.3 7.9 1.4 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) FYDLN_acid PF09538.10 CDI87862.1 - 9.6 6.9 12.6 14 6.4 9.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF3273 PF11677.8 CDI87864.1 - 2.5e-69 233.6 10.7 2.9e-69 233.4 10.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) RskA PF10099.9 CDI87865.1 - 0.00063 20.1 10.1 0.00063 20.1 10.1 5.6 3 3 1 4 4 1 1 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI87865.1 - 0.0074 15.3 14.1 0.0074 15.3 14.1 2.5 2 0 0 2 2 2 1 Transcriptional activator LAG-3 eIF3_subunit PF08597.10 CDI87865.1 - 0.01 15.8 0.5 0.01 15.8 0.5 3.0 3 1 0 3 3 3 0 Translation initiation factor eIF3 subunit Apt1 PF10351.9 CDI87865.1 - 0.036 12.9 3.0 0.052 12.4 3.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 CDI87865.1 - 0.046 13.3 8.2 0.071 12.7 8.2 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Roughex PF06020.11 CDI87865.1 - 0.21 10.6 7.3 0.47 9.5 7.3 1.6 1 0 0 1 1 1 0 Drosophila roughex protein PAT1 PF09770.9 CDI87865.1 - 0.65 8.2 11.4 0.95 7.7 11.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Gcd10p PF04189.13 CDI87865.1 - 0.8 8.8 5.4 1.3 8.0 5.4 1.2 1 0 0 1 1 1 0 Gcd10p family ORC5_C PF14630.6 CDI87865.1 - 1.2 8.6 7.4 0.25 10.8 2.0 2.2 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus Suf PF05843.14 CDI87865.1 - 1.5 8.8 13.2 0.1 12.6 6.1 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Gti1_Pac2 PF09729.9 CDI87865.1 - 2.2 8.3 8.2 4.7 7.3 8.2 1.5 1 0 0 1 1 1 0 Gti1/Pac2 family SLC12 PF03522.15 CDI87865.1 - 5.8 5.8 10.3 8.8 5.2 10.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Mucin PF01456.17 CDI87866.1 - 0.0019 18.2 4.4 0.0025 17.8 4.4 1.3 1 0 0 1 1 1 1 Mucin-like glycoprotein HSD3 PF15244.6 CDI87866.1 - 0.0042 16.6 15.6 0.005 16.4 15.6 1.0 1 0 0 1 1 1 1 Spermatogenesis-associated protein 7, or HSD3 FAM76 PF16046.5 CDI87866.1 - 0.011 15.1 20.8 0.014 14.8 20.8 1.1 1 0 0 1 1 1 0 FAM76 protein BAF1_ABF1 PF04684.13 CDI87866.1 - 0.026 13.6 18.1 0.028 13.5 18.1 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor PTPRCAP PF15713.5 CDI87866.1 - 0.1 12.9 21.7 0.14 12.5 21.7 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated GHMP_kinases_N PF00288.26 CDI87866.1 - 0.11 12.8 0.1 0.11 12.8 0.1 2.1 2 0 0 2 2 2 0 GHMP kinases N terminal domain TFIIA PF03153.13 CDI87866.1 - 0.14 12.1 47.2 0.19 11.7 47.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 CDI87866.1 - 0.22 9.4 16.2 0.29 9.0 16.2 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vfa1 PF08432.10 CDI87866.1 - 0.28 11.5 20.7 0.34 11.2 20.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 TAF4 PF05236.14 CDI87866.1 - 0.31 10.7 23.1 0.4 10.4 23.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DUF2464 PF10240.9 CDI87866.1 - 0.38 10.3 13.9 0.48 10.0 13.9 1.3 1 0 0 1 1 1 0 Multivesicular body subunit 12 Presenilin PF01080.17 CDI87866.1 - 0.4 9.4 30.0 0.48 9.1 30.0 1.0 1 0 0 1 1 1 0 Presenilin SOBP PF15279.6 CDI87866.1 - 0.44 11.1 26.0 0.52 10.9 26.0 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein PNISR PF15996.5 CDI87866.1 - 0.55 10.5 27.9 0.65 10.2 27.9 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR CDC45 PF02724.14 CDI87866.1 - 0.83 7.9 20.8 0.97 7.6 20.8 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF1635 PF07795.11 CDI87866.1 - 0.83 9.5 25.1 1 9.2 25.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) PMSI1 PF15322.6 CDI87866.1 - 0.92 8.9 19.6 1.1 8.6 19.6 1.0 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative RAP1 PF07218.11 CDI87866.1 - 0.99 7.6 5.0 0.97 7.6 5.0 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF2052 PF09747.9 CDI87866.1 - 1 9.4 21.8 1.3 9.2 21.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PAT1 PF09770.9 CDI87866.1 - 1 7.5 40.5 1.3 7.2 40.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MMR1 PF08505.10 CDI87866.1 - 1.3 9.2 27.2 1.7 8.8 27.2 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF4551 PF15087.6 CDI87866.1 - 1.4 7.7 21.8 1.6 7.4 21.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) MAP65_ASE1 PF03999.12 CDI87866.1 - 1.9 7.1 24.9 2.1 6.9 24.9 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) RPN2_C PF18004.1 CDI87866.1 - 1.9 8.4 27.2 0.084 12.8 2.3 2.0 1 1 1 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4770 PF15994.5 CDI87866.1 - 1.9 8.7 21.7 2.8 8.2 21.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Sec62 PF03839.16 CDI87866.1 - 2.1 7.8 17.8 2.5 7.5 17.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 FAM60A PF15396.6 CDI87866.1 - 2.2 8.2 20.5 2.7 7.9 20.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Apt1 PF10351.9 CDI87866.1 - 2.3 7.0 21.3 2.6 6.8 21.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain SLC12 PF03522.15 CDI87866.1 - 2.3 7.2 25.8 2.7 6.9 25.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Miga PF10265.9 CDI87866.1 - 2.5 7.0 18.3 2.9 6.8 18.3 1.0 1 0 0 1 1 1 0 Mitoguardin Raftlin PF15250.6 CDI87866.1 - 2.6 6.7 18.2 2.9 6.6 18.2 1.0 1 0 0 1 1 1 0 Raftlin Bud13 PF09736.9 CDI87866.1 - 2.7 8.4 24.4 4.4 7.7 24.4 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex DUF4746 PF15928.5 CDI87866.1 - 3.1 7.1 14.3 4.3 6.7 14.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) eIF-3_zeta PF05091.12 CDI87866.1 - 3.3 6.6 24.5 4.8 6.0 24.5 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Hamartin PF04388.12 CDI87866.1 - 3.6 6.1 22.7 4.1 5.9 22.7 1.0 1 0 0 1 1 1 0 Hamartin protein SMYLE_N PF18615.1 CDI87866.1 - 3.7 7.0 19.5 4.6 6.7 19.5 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Menin PF05053.13 CDI87866.1 - 3.9 5.7 19.8 4.3 5.6 19.8 1.0 1 0 0 1 1 1 0 Menin Membralin PF09746.9 CDI87866.1 - 4.2 6.3 14.4 4.8 6.1 14.4 1.1 1 0 0 1 1 1 0 Tumour-associated protein GREB1 PF15782.5 CDI87866.1 - 4.3 4.3 25.3 4.7 4.2 25.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2151 PF10221.9 CDI87866.1 - 4.5 5.8 16.6 5.2 5.5 16.6 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator DUF913 PF06025.12 CDI87866.1 - 4.5 6.2 15.3 5.9 5.8 15.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDRT4 PF15213.6 CDI87866.1 - 4.8 7.8 10.2 6.4 7.4 10.2 1.2 1 0 0 1 1 1 0 CMT1A duplicated region transcript 4 protein Peptidase_S64 PF08192.11 CDI87866.1 - 5.4 5.4 24.4 5.7 5.3 24.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF1387 PF07139.11 CDI87866.1 - 5.7 6.6 23.5 8 6.1 23.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF3807 PF12720.7 CDI87866.1 - 6.4 7.0 31.5 8.8 6.6 31.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) PA26 PF04636.13 CDI87866.1 - 7 5.5 16.6 8.2 5.2 16.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Kinesin_assoc PF16183.5 CDI87866.1 - 7 6.8 7.8 8.5 6.5 7.8 1.1 1 0 0 1 1 1 0 Kinesin-associated EBP50_C PF09007.11 CDI87866.1 - 7 7.6 26.9 9.1 7.3 26.9 1.2 1 0 0 1 1 1 0 EBP50, C-terminal DUF966 PF06136.13 CDI87866.1 - 7.6 6.2 23.1 9.2 5.9 23.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Rtf2 PF04641.12 CDI87866.1 - 8.1 5.7 23.0 11 5.2 23.0 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger PPL5 PF18168.1 CDI87866.1 - 8.6 5.6 15.1 12 5.0 15.1 1.3 1 0 0 1 1 1 0 Prim-pol family 5 CCSAP PF15748.5 CDI87866.1 - 8.7 6.4 31.3 10 6.2 31.3 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SID-1_RNA_chan PF13965.6 CDI87866.1 - 8.7 4.6 13.4 10 4.4 13.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TMEM151 PF14857.6 CDI87866.1 - 9.3 5.1 13.7 10 4.9 13.7 1.1 1 0 0 1 1 1 0 TMEM151 family DUF4175 PF13779.6 CDI87866.1 - 9.4 4.0 44.9 12 3.6 44.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Otopetrin PF03189.13 CDI87866.1 - 9.5 4.9 13.5 12 4.6 13.5 1.2 1 0 0 1 1 1 0 Otopetrin SRP-alpha_N PF04086.13 CDI87866.1 - 9.9 6.0 26.2 12 5.7 26.2 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF2828 PF11443.8 CDI87866.1 - 9.9 4.1 19.4 11 3.9 19.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4661 PF15576.6 CDI87866.1 - 9.9 6.0 10.9 12 5.7 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) NESP55 PF06390.12 CDI87867.1 - 1.7 8.2 17.3 2.3 7.8 17.3 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Trypan_PARP PF05887.11 CDI87867.1 - 2.9 7.9 15.7 3.6 7.6 15.7 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) RskA PF10099.9 CDI87870.1 - 0.066 13.5 0.1 0.066 13.5 0.1 3.2 1 1 0 2 2 2 0 Anti-sigma-K factor rskA Exonuc_VII_L PF02601.15 CDI87870.1 - 5.3 6.5 25.4 8.6 5.8 25.4 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit CDC45 PF02724.14 CDI87870.1 - 9.1 4.4 26.6 13 3.9 26.6 1.3 1 0 0 1 1 1 0 CDC45-like protein Hamartin PF04388.12 CDI87870.1 - 9.8 4.7 27.2 11 4.5 27.2 1.0 1 0 0 1 1 1 0 Hamartin protein TFIIA PF03153.13 CDI87871.1 - 1.9e-05 24.9 25.9 2.4e-05 24.5 25.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Borrelia_P83 PF05262.11 CDI87871.1 - 0.0012 17.4 0.6 0.0012 17.4 0.6 1.2 1 0 0 1 1 1 1 Borrelia P83/100 protein EIIBC-GUT_N PF03612.14 CDI87871.1 - 0.66 9.7 5.4 1.5 8.5 5.4 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4407 PF14362.6 CDI87871.1 - 0.67 9.3 9.0 0.036 13.4 4.2 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF4781 PF16013.5 CDI87871.1 - 1.5 7.5 6.6 0.089 11.6 1.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) CSG2 PF16965.5 CDI87871.1 - 7.3 5.4 6.3 13 4.6 6.3 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator RNF220 PF15926.5 CDI87872.1 - 0.0018 18.0 14.0 0.0018 18.0 14.0 3.2 2 1 1 4 4 4 1 E3 ubiquitin-protein ligase RNF220 RskA PF10099.9 CDI87872.1 - 0.0053 17.1 15.7 0.0053 17.1 15.7 5.4 2 2 2 5 5 5 3 Anti-sigma-K factor rskA APC_u13 PF16634.5 CDI87874.1 - 1.7 8.6 4.2 11 6.0 1.4 2.4 1 1 1 2 2 2 0 Unstructured region on APC between APC_crr and SAMP PKcGMP_CC PF16808.5 CDI87875.1 - 0.1 12.4 0.4 0.19 11.6 0.4 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase LicD PF04991.13 CDI87877.1 - 0.17 12.0 2.9 0.12 12.5 0.2 1.9 2 0 0 2 2 2 0 LicD family Pex14_N PF04695.13 CDI87877.1 - 1.3 9.7 42.1 1.5 9.5 11.3 3.3 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Methyltr_RsmB-F PF01189.17 CDI87878.1 - 0.044 13.4 1.9 0.049 13.3 1.3 1.3 1 1 0 1 1 1 0 16S rRNA methyltransferase RsmB/F DUF5614 PF18474.1 CDI87878.1 - 0.076 12.3 1.5 0.1 11.9 1.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5614) DUF2753 PF10952.8 CDI87878.1 - 0.11 12.6 1.8 0.16 12.1 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2753) DUF4193 PF13834.6 CDI87878.1 - 0.19 12.2 2.2 0.27 11.8 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4193) SelP_N PF04592.14 CDI87879.1 - 0.051 13.0 30.8 0.053 12.9 30.8 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Miga PF10265.9 CDI87879.1 - 0.53 9.2 10.6 0.52 9.2 10.6 1.1 1 0 0 1 1 1 0 Mitoguardin DcuC PF03606.15 CDI87879.1 - 0.6 8.5 4.4 0.68 8.3 4.4 1.1 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier SID-1_RNA_chan PF13965.6 CDI87879.1 - 1.6 7.0 7.6 1.5 7.1 7.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Pex14_N PF04695.13 CDI87879.1 - 1.9 9.1 31.5 2.3 8.9 31.5 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RPN2_C PF18004.1 CDI87879.1 - 2.2 8.2 16.3 2.3 8.1 16.3 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Macoilin PF09726.9 CDI87879.1 - 3.2 6.2 20.8 4.2 5.8 20.8 1.2 1 0 0 1 1 1 0 Macoilin family DUF3292 PF11696.8 CDI87879.1 - 3.2 6.0 20.8 4.1 5.6 20.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DcuA_DcuB PF03605.14 CDI87879.1 - 4 6.2 7.1 4.4 6.1 7.1 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter HemX PF04375.14 CDI87879.1 - 4.5 6.5 35.3 4.6 6.4 35.3 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Peptidase_S49_N PF08496.10 CDI87879.1 - 5.1 7.1 15.8 6.1 6.9 15.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Pannexin_like PF12534.8 CDI87879.1 - 5.6 6.0 13.0 5.3 6.0 13.0 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Ureide_permease PF07168.11 CDI87879.1 - 7 5.3 11.0 7.1 5.3 11.0 1.2 1 0 0 1 1 1 0 Ureide permease TERB2 PF15101.6 CDI87879.1 - 7 6.6 23.3 7.8 6.5 23.3 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Neur_chan_memb PF02932.16 CDI87879.1 - 7.8 6.5 15.8 7.9 6.5 15.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM60A PF15396.6 CDI87879.1 - 8.2 6.4 16.3 8.5 6.3 16.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF1980 PF09323.10 CDI87879.1 - 8.6 6.2 13.6 9.7 6.1 13.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) BAF1_ABF1 PF04684.13 CDI87879.1 - 9.3 5.2 26.3 10 5.0 26.3 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Bac_luciferase PF00296.20 CDI87879.1 - 9.6 5.5 19.7 12 5.2 19.7 1.0 1 0 0 1 1 1 0 Luciferase-like monooxygenase ArsA_ATPase PF02374.15 CDI87881.1 - 0.073 12.2 0.1 0.097 11.8 0.1 1.2 1 0 0 1 1 1 0 Anion-transporting ATPase ERM PF00769.19 CDI87881.1 - 0.16 11.7 26.1 0.21 11.4 26.1 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family SR-25 PF10500.9 CDI87881.1 - 0.69 9.5 33.5 0.6 9.7 6.7 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI87882.1 - 0.0017 18.5 19.8 0.0023 18.0 19.8 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SURF6 PF04935.12 CDI87882.1 - 0.092 12.5 9.6 0.12 12.1 9.6 1.1 1 0 0 1 1 1 0 Surfeit locus protein 6 Mitofilin PF09731.9 CDI87882.1 - 0.3 9.9 14.5 0.34 9.7 14.5 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Utp14 PF04615.13 CDI87882.1 - 0.51 8.8 18.6 0.56 8.7 18.6 1.0 1 0 0 1 1 1 0 Utp14 protein Roughex PF06020.11 CDI87882.1 - 1.1 8.3 14.7 2.3 7.3 14.7 1.5 1 0 0 1 1 1 0 Drosophila roughex protein PNISR PF15996.5 CDI87882.1 - 2.1 8.6 15.9 2.9 8.1 15.9 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR SRP-alpha_N PF04086.13 CDI87882.1 - 4.7 7.0 18.2 6.1 6.7 18.2 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SLC12 PF03522.15 CDI87882.1 - 4.8 6.1 18.8 6.2 5.7 18.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF4366 PF14283.6 CDI87882.1 - 7.4 6.6 9.0 4 7.5 6.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) RskA PF10099.9 CDI87883.1 - 0.0032 17.8 4.3 0.0032 17.8 4.3 2.1 1 1 1 2 2 2 1 Anti-sigma-K factor rskA CbiD PF01888.17 CDI87883.1 - 0.83 8.9 5.6 0.48 9.7 4.0 1.4 1 1 0 1 1 1 0 CbiD SR-25 PF10500.9 CDI87883.1 - 1.1 8.8 33.4 8.8 5.9 33.4 1.9 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein SART-1 PF03343.13 CDI87883.1 - 3.7 6.0 35.6 4.1 5.8 35.6 1.0 1 0 0 1 1 1 0 SART-1 family SARAF PF06682.12 CDI87883.1 - 6.2 6.4 29.8 8.5 5.9 29.8 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis MAP7 PF05672.11 CDI87883.1 - 7.6 6.2 44.0 1.3 8.7 39.9 1.6 1 1 1 2 2 2 0 MAP7 (E-MAP-115) family Mcm10 PF09332.11 CDI87884.1 - 6.2 6.2 12.2 7.2 5.9 12.2 1.1 1 0 0 1 1 1 0 Mcm10 replication factor Activator_LAG-3 PF11498.8 CDI87886.1 - 0.00051 19.1 80.8 0.0074 15.3 41.4 3.2 3 0 0 3 3 3 3 Transcriptional activator LAG-3 DUF98 PF01947.16 CDI87886.1 - 0.21 11.5 5.6 0.52 10.3 4.7 2.0 1 1 0 1 1 1 0 p-hydroxybenzoic acid synthase TPR_11 PF13414.6 CDI87887.1 - 3.8e-09 36.1 2.9 5.2e-05 22.8 0.4 3.2 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.17 CDI87887.1 - 1.3e-08 34.3 11.0 0.00014 21.7 0.2 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDI87887.1 - 1.6e-08 35.0 2.5 6.2e-07 30.0 1.4 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDI87887.1 - 1.3e-05 25.2 0.4 0.34 11.4 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDI87887.1 - 1.5e-05 24.6 9.9 0.0069 16.2 0.5 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDI87887.1 - 3.2e-05 24.4 2.2 0.0025 18.3 0.6 2.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDI87887.1 - 0.00051 20.1 3.2 0.0027 17.8 0.3 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI87887.1 - 0.00076 20.1 2.4 0.015 16.1 0.1 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDI87887.1 - 0.0055 16.8 0.3 0.012 15.7 0.3 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI87887.1 - 0.011 15.9 4.0 0.016 15.4 0.4 2.6 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CDI87887.1 - 0.012 15.9 4.1 0.025 14.9 1.0 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDI87887.1 - 0.02 15.5 1.6 2.7 8.8 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 CDI87887.1 - 0.031 14.6 0.9 0.1 13.0 0.9 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat NDUFB10 PF10249.9 CDI87887.1 - 0.18 12.3 2.5 0.18 12.3 0.3 1.9 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase subunit 10 MIT PF04212.18 CDI87887.1 - 6.9 6.8 12.6 0.4 10.8 0.8 2.9 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain Presenilin PF01080.17 CDI87889.1 - 0.85 8.3 44.6 0.95 8.2 44.6 1.0 1 0 0 1 1 1 0 Presenilin Endostatin PF06482.11 CDI87889.1 - 3.7 6.9 41.9 4.8 6.6 41.9 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SLC12 PF03522.15 CDI87889.1 - 5.7 5.9 40.4 6.5 5.7 40.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI87889.1 - 8 4.5 35.8 8 4.4 35.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM60A PF15396.6 CDI87889.1 - 8.7 6.3 30.6 12 5.8 30.6 1.3 1 0 0 1 1 1 0 Protein Family FAM60A SR-25 PF10500.9 CDI87890.1 - 3.5e-08 33.3 25.4 9.9e-06 25.3 10.9 2.1 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI87890.1 - 8.7e-05 22.9 0.3 0.00016 22.0 0.1 1.6 1 1 0 1 1 1 1 Anti-sigma-K factor rskA Roughex PF06020.11 CDI87890.1 - 0.00069 18.8 7.6 0.0011 18.2 7.6 1.3 1 0 0 1 1 1 1 Drosophila roughex protein Nop53 PF07767.11 CDI87890.1 - 0.01 15.3 12.9 0.01 15.3 12.9 1.4 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) MFMR_assoc PF16596.5 CDI87890.1 - 0.013 16.0 10.2 0.013 16.0 10.2 2.2 2 0 0 2 2 2 0 Disordered region downstream of MFMR NARP1 PF12569.8 CDI87890.1 - 0.014 14.3 9.5 0.023 13.6 9.5 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF913 PF06025.12 CDI87890.1 - 0.058 12.4 10.3 0.047 12.7 7.1 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) CCDC106 PF15794.5 CDI87890.1 - 0.059 13.1 20.8 0.57 9.8 12.5 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 DUF4175 PF13779.6 CDI87890.1 - 0.06 11.3 20.4 0.089 10.7 20.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Peptidase_S49_N PF08496.10 CDI87890.1 - 0.085 12.9 8.4 0.034 14.2 5.3 1.7 2 0 0 2 2 2 0 Peptidase family S49 N-terminal IMUP PF15761.5 CDI87890.1 - 0.23 12.1 27.8 2.1 9.1 12.9 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein MecA PF05389.12 CDI87890.1 - 0.24 11.0 9.5 0.13 11.9 6.2 1.9 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF4407 PF14362.6 CDI87890.1 - 0.26 10.6 13.1 0.34 10.2 13.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF572 PF04502.13 CDI87890.1 - 0.3 10.7 17.7 0.4 10.3 17.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Connexin PF00029.19 CDI87890.1 - 0.37 10.5 7.6 0.25 11.1 5.2 1.8 2 0 0 2 2 2 0 Connexin Het-C PF07217.11 CDI87890.1 - 0.59 8.6 11.0 0.94 7.9 11.0 1.3 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF4446 PF14584.6 CDI87890.1 - 0.62 10.0 3.9 1.4 8.9 3.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) eIF-3_zeta PF05091.12 CDI87890.1 - 1.3 7.9 16.7 0.12 11.3 12.5 1.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RLL PF10036.9 CDI87890.1 - 1.6 8.5 23.2 0.26 11.1 12.1 2.1 1 1 1 2 2 2 0 RNA transcription, translation and transport factor protein CDC45 PF02724.14 CDI87890.1 - 1.7 6.9 20.5 2.8 6.1 20.5 1.4 1 1 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 CDI87890.1 - 2.1 8.1 14.5 3.7 7.3 14.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4614 PF15391.6 CDI87890.1 - 2.5 8.1 27.8 3.7 7.5 17.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) SLX9 PF15341.6 CDI87890.1 - 2.6 8.5 17.9 0.26 11.7 11.0 2.1 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 DUF4770 PF15994.5 CDI87890.1 - 4.6 7.5 21.8 0.21 11.8 15.6 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4770) Golgin_A5 PF09787.9 CDI87890.1 - 4.9 6.5 25.9 0.57 9.6 19.4 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 Raftlin PF15250.6 CDI87890.1 - 5 5.8 16.6 1.1 7.9 12.7 1.7 2 0 0 2 2 2 0 Raftlin TFIIA PF03153.13 CDI87890.1 - 5.7 6.8 47.7 10 6.0 47.3 1.4 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit AF-4 PF05110.13 CDI87890.1 - 7.2 4.6 36.7 0.46 8.5 19.9 2.2 2 0 0 2 2 2 0 AF-4 proto-oncoprotein MCU PF04678.13 CDI87890.1 - 7.9 6.5 10.8 3.9 7.6 8.3 1.7 2 0 0 2 2 2 0 Mitochondrial calcium uniporter FYTT PF07078.11 CDI87891.1 - 5e-05 22.8 7.3 7.6e-05 22.2 7.3 1.2 1 0 0 1 1 1 1 Forty-two-three protein Androgen_recep PF02166.16 CDI87891.1 - 0.0035 16.3 14.9 0.0044 15.9 14.9 1.1 1 0 0 1 1 1 1 Androgen receptor DDHD PF02862.17 CDI87891.1 - 0.0035 17.5 0.2 0.0036 17.5 0.2 1.2 1 0 0 1 1 1 1 DDHD domain DUF4666 PF15697.5 CDI87891.1 - 0.0082 16.8 3.4 0.011 16.4 3.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4666) EPL1 PF10513.9 CDI87891.1 - 0.014 15.8 3.6 0.015 15.7 3.6 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like V_ATPase_I PF01496.19 CDI87891.1 - 0.017 13.1 0.6 0.015 13.3 0.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spt20 PF12090.8 CDI87891.1 - 0.02 14.5 24.1 0.024 14.3 24.1 1.1 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 CDI87891.1 - 0.023 13.7 22.0 0.025 13.6 22.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) SMN PF06003.12 CDI87891.1 - 0.029 13.6 0.4 0.034 13.4 0.4 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DUF4770 PF15994.5 CDI87891.1 - 0.029 14.6 6.6 0.037 14.3 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) TERB2 PF15101.6 CDI87891.1 - 0.029 14.4 7.3 0.035 14.2 7.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SpoIIP PF07454.11 CDI87891.1 - 0.036 13.5 4.4 0.038 13.5 4.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4407 PF14362.6 CDI87891.1 - 0.06 12.7 5.5 0.059 12.7 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PepSY_TM PF03929.16 CDI87891.1 - 0.21 11.2 1.4 0.23 11.1 1.4 1.1 1 0 0 1 1 1 0 PepSY-associated TM region TFIIA PF03153.13 CDI87891.1 - 0.26 11.2 19.0 0.3 11.0 19.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PRC2_HTH_1 PF18118.1 CDI87891.1 - 0.27 12.1 5.2 0.35 11.7 5.2 1.1 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Activator_LAG-3 PF11498.8 CDI87891.1 - 0.44 9.5 22.8 0.52 9.2 22.8 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 ANAPC_CDC26 PF10471.9 CDI87891.1 - 0.49 11.3 26.2 0.94 10.4 26.2 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 FAM176 PF14851.6 CDI87891.1 - 0.54 9.9 3.4 0.7 9.5 3.4 1.1 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 CDI87891.1 - 0.57 8.4 8.8 0.63 8.3 8.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI87891.1 - 0.61 8.8 8.9 0.66 8.7 8.9 1.0 1 0 0 1 1 1 0 Presenilin Hydin_ADK PF17213.3 CDI87891.1 - 0.78 10.0 7.6 0.96 9.7 7.6 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF3408 PF11888.8 CDI87891.1 - 0.86 9.7 9.5 1.1 9.4 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF1764 PF08576.10 CDI87891.1 - 0.94 10.4 11.6 1.2 10.0 11.6 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF4834 PF16118.5 CDI87891.1 - 0.97 10.4 13.1 1.5 9.8 13.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SRRM_C PF15230.6 CDI87891.1 - 1.2 9.7 9.8 2 9.1 9.8 1.3 1 0 0 1 1 1 0 Serine/arginine repetitive matrix protein C-terminus CobT PF06213.12 CDI87891.1 - 2 7.7 12.4 2.4 7.5 12.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3499 PF12005.8 CDI87891.1 - 2.3 8.9 6.3 3 8.5 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3499) DUF3464 PF11947.8 CDI87891.1 - 2.5 7.8 9.3 3.7 7.3 9.3 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 eIF-3_zeta PF05091.12 CDI87891.1 - 2.8 6.8 14.2 3.2 6.6 14.2 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TMEM51 PF15345.6 CDI87891.1 - 3.6 7.4 10.8 4.5 7.0 10.8 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4175 PF13779.6 CDI87891.1 - 3.9 5.3 20.4 4.5 5.1 20.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Roughex PF06020.11 CDI87891.1 - 4.2 6.4 9.9 4.7 6.2 9.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Orf78 PF06024.12 CDI87891.1 - 4.4 7.7 6.6 5.9 7.2 6.6 1.2 1 0 0 1 1 1 0 Orf78 (ac78) Cyclin PF08613.11 CDI87891.1 - 4.6 7.6 6.4 5.8 7.3 6.4 1.2 1 0 0 1 1 1 0 Cyclin Ndc1_Nup PF09531.10 CDI87891.1 - 4.7 5.8 7.7 5.2 5.6 7.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Coilin_N PF15862.5 CDI87891.1 - 4.7 7.0 13.2 6 6.7 13.2 1.2 1 0 0 1 1 1 0 Coilin N-terminus Neur_chan_memb PF02932.16 CDI87891.1 - 4.7 7.2 6.1 5.4 7.0 6.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Folliculin PF11704.8 CDI87891.1 - 5.1 6.9 8.5 6.4 6.6 8.5 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Band_3_cyto PF07565.13 CDI87891.1 - 6.3 6.5 8.7 7.6 6.2 8.7 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Connexin PF00029.19 CDI87891.1 - 6.5 6.4 7.3 7.6 6.2 7.3 1.1 1 0 0 1 1 1 0 Connexin ALMT PF11744.8 CDI87891.1 - 7.1 5.3 8.2 8.2 5.1 8.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Peptidase_S49_N PF08496.10 CDI87891.1 - 7.3 6.6 9.7 8.7 6.4 9.7 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal EIIBC-GUT_N PF03612.14 CDI87891.1 - 7.6 6.2 9.1 9.7 5.9 9.1 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF853 PF05872.12 CDI87891.1 - 7.7 5.0 8.5 9.2 4.7 8.5 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) UPF0560 PF10577.9 CDI87891.1 - 9.9 4.5 14.1 11 4.3 14.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Tmemb_9 PF05434.11 CDI87892.1 - 0.00029 20.7 7.7 0.00029 20.7 7.7 5.2 1 1 3 5 5 5 1 TMEM9 SPX PF03105.19 CDI87892.1 - 1.6 8.6 16.5 2.1 8.2 16.5 1.1 1 0 0 1 1 1 0 SPX domain MID_MedPIWI PF18296.1 CDI87892.1 - 1.8 8.3 16.9 2.4 7.9 16.9 1.1 1 0 0 1 1 1 0 MID domain of medPIWI FAM76 PF16046.5 CDI87892.1 - 3.7 6.8 7.4 4.6 6.5 7.4 1.2 1 0 0 1 1 1 0 FAM76 protein SF3b1 PF08920.10 CDI87893.1 - 1.1 9.7 8.4 0.72 10.4 0.4 3.2 2 1 1 3 3 3 0 Splicing factor 3B subunit 1 Coilin_N PF15862.5 CDI87894.1 - 0.00035 20.4 6.4 0.00056 19.7 6.4 1.4 1 0 0 1 1 1 1 Coilin N-terminus DDHD PF02862.17 CDI87894.1 - 0.0014 18.9 1.0 0.0014 18.9 1.0 1.2 1 0 0 1 1 1 1 DDHD domain O-antigen_lig PF13425.6 CDI87894.1 - 0.0034 16.3 7.9 0.0042 15.9 7.9 1.1 1 0 0 1 1 1 1 O-antigen ligase like membrane protein YfhO PF09586.10 CDI87894.1 - 0.014 13.7 14.2 0.022 13.1 14.2 1.3 1 0 0 1 1 1 0 Bacterial membrane protein YfhO SpoIIP PF07454.11 CDI87894.1 - 0.015 14.8 10.1 0.019 14.4 10.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Mem_trans PF03547.18 CDI87894.1 - 0.057 11.8 8.6 0.079 11.3 8.6 1.2 1 0 0 1 1 1 0 Membrane transport protein MMM1 PF10296.9 CDI87894.1 - 0.07 12.2 9.2 0.091 11.8 9.2 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Wzy_C PF04932.15 CDI87894.1 - 0.12 12.0 1.6 0.21 11.2 1.6 1.5 1 1 0 1 1 1 0 O-Antigen ligase SelP_N PF04592.14 CDI87894.1 - 0.15 11.4 15.5 0.24 10.8 15.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SID-1_RNA_chan PF13965.6 CDI87894.1 - 0.24 9.8 12.9 0.39 9.1 12.9 1.4 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2828 PF11443.8 CDI87894.1 - 0.34 8.9 18.4 0.45 8.5 18.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4834 PF16118.5 CDI87894.1 - 0.36 11.8 24.6 5.4 8.1 24.6 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) CBP_BcsG PF11658.8 CDI87894.1 - 0.38 9.1 20.9 1.1 7.6 20.9 1.7 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsG CPSF100_C PF13299.6 CDI87894.1 - 0.48 10.6 10.3 0.7 10.1 10.3 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CobT PF06213.12 CDI87894.1 - 0.51 9.7 19.4 0.65 9.3 19.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Folliculin PF11704.8 CDI87894.1 - 1.5 8.7 8.9 2.1 8.2 8.9 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Afi1 PF07792.12 CDI87894.1 - 1.5 9.3 13.6 2.5 8.6 13.6 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Gastrin PF00918.17 CDI87894.1 - 1.6 9.7 13.0 3.2 8.8 13.0 1.5 1 0 0 1 1 1 0 Gastrin/cholecystokinin family DUF2126 PF09899.9 CDI87894.1 - 2.1 6.3 12.9 2.8 5.9 12.9 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) TFIIA PF03153.13 CDI87894.1 - 2.2 8.2 31.1 2.7 7.9 31.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Endonuc_Holl PF10107.9 CDI87894.1 - 2.7 7.8 16.5 4.9 7.0 16.5 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase EPL1 PF10513.9 CDI87894.1 - 3.1 8.1 16.0 4.4 7.7 16.0 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like YABBY PF04690.13 CDI87894.1 - 3.3 8.2 13.8 5.3 7.6 13.8 1.2 1 0 0 1 1 1 0 YABBY protein DUF4637 PF15470.6 CDI87894.1 - 3.5 7.3 12.7 5.7 6.6 12.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Pex24p PF06398.11 CDI87894.1 - 3.9 6.3 10.9 13 4.7 10.9 1.8 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin OATP PF03137.20 CDI87894.1 - 5 5.3 12.3 0.09 11.0 5.5 1.6 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Suf PF05843.14 CDI87894.1 - 5 7.0 15.7 6.9 6.6 15.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) UPF0565 PF10561.9 CDI87894.1 - 5.1 6.2 12.2 7.2 5.7 12.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 V_ATPase_I PF01496.19 CDI87894.1 - 5.4 4.8 27.5 7.9 4.3 27.5 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family AIF_C PF14721.6 CDI87894.1 - 6.2 7.2 11.4 9.6 6.6 11.4 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Paf1 PF03985.13 CDI87894.1 - 7.7 5.4 20.5 11 4.8 20.5 1.2 1 0 0 1 1 1 0 Paf1 TERB2 PF15101.6 CDI87894.1 - 7.8 6.5 20.0 10 6.1 20.0 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 MMR1 PF08505.10 CDI87894.1 - 8.8 6.5 19.3 11 6.2 19.3 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein RED_N PF07808.13 CDI87894.1 - 9.2 5.8 23.0 20 4.6 23.0 1.5 1 0 0 1 1 1 0 RED-like protein N-terminal region RR_TM4-6 PF06459.12 CDI87894.1 - 9.2 6.0 19.7 14 5.4 19.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Exonuc_VII_L PF02601.15 CDI87894.1 - 9.9 5.6 16.4 10 5.6 16.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TFIIA PF03153.13 CDI87895.1 - 4.2 7.3 23.1 4.6 7.1 23.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cys_Met_Meta_PP PF01053.20 CDI87896.1 - 2.5e-115 385.1 0.1 2.1e-65 220.8 0.0 2.0 2 0 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CDI87896.1 - 4.6e-06 26.2 0.2 4.7e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CDI87896.1 - 0.0035 16.6 0.0 0.0066 15.7 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II DUF2722 PF10846.8 CDI87897.1 - 0.0055 15.7 11.2 0.0073 15.3 11.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI87897.1 - 0.019 15.6 7.0 0.019 15.6 7.0 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Suf PF05843.14 CDI87897.1 - 0.043 13.8 4.4 0.064 13.2 4.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CCDC53 PF10152.9 CDI87897.1 - 0.39 11.1 8.2 0.092 13.2 0.3 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex SpoIIP PF07454.11 CDI87897.1 - 0.45 9.9 4.6 0.65 9.4 4.6 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PGA2 PF07543.12 CDI87897.1 - 0.67 9.9 5.2 1.1 9.3 5.2 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF3391 PF11871.8 CDI87897.1 - 2.4 8.7 8.1 0.44 11.1 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) DUF3464 PF11947.8 CDI87897.1 - 3.1 7.5 6.3 6.1 6.6 6.3 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 TFIIA PF03153.13 CDI87897.1 - 3.6 7.5 20.8 0.053 13.5 12.5 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 CDI87897.1 - 3.8 8.5 7.2 6.1 7.9 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI87897.1 - 4.7 6.8 23.7 6.9 6.2 23.7 1.1 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 CDI87897.1 - 8.9 5.0 5.2 13 4.5 5.2 1.1 1 0 0 1 1 1 0 Presenilin DUF3682 PF12446.8 CDI87899.1 - 0.0018 18.7 12.2 0.0022 18.5 12.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3682) Shadoo PF14999.6 CDI87899.1 - 0.022 14.9 6.8 0.026 14.6 6.8 1.1 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective Myc_N PF01056.18 CDI87899.1 - 0.069 13.0 1.5 0.08 12.8 1.5 1.1 1 0 0 1 1 1 0 Myc amino-terminal region FSA_C PF10479.9 CDI87899.1 - 0.43 8.7 7.0 0.42 8.7 7.0 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus TFIIE-A_C PF11521.8 CDI87899.1 - 2.3 8.6 7.7 7.4 6.9 7.7 1.7 1 1 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Rubella_E2 PF05749.11 CDI87899.1 - 3.5 7.0 7.1 3.9 6.9 7.1 1.1 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 Med3 PF11593.8 CDI87899.1 - 6.9 5.7 11.5 7.8 5.6 11.5 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal K_channel_TID PF07941.11 CDI87901.1 - 0.039 14.4 12.9 0.039 14.4 12.9 9.2 5 3 3 8 8 8 0 Potassium channel Kv1.4 tandem inactivation domain GREB1 PF15782.5 CDI87901.1 - 8.2 3.4 15.2 11 3.0 15.2 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4647 PF15504.6 CDI87901.1 - 9.1 5.3 13.8 14 4.7 13.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Activator_LAG-3 PF11498.8 CDI87902.1 - 0.0033 16.5 13.2 0.0033 16.5 13.2 4.3 4 0 0 4 4 4 2 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI87902.1 - 0.0086 15.7 4.9 0.0086 15.7 4.9 5.0 3 1 2 5 5 5 1 Spt20 family HTH_28 PF13518.6 CDI87902.1 - 0.26 11.5 0.0 0.26 11.5 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain SPX PF03105.19 CDI87903.1 - 0.052 13.5 19.5 0.066 13.1 19.5 1.1 1 0 0 1 1 1 0 SPX domain DUF726 PF05277.12 CDI87903.1 - 0.15 11.0 0.8 0.19 10.6 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Cwf_Cwc_15 PF04889.12 CDI87903.1 - 0.61 9.8 8.2 0.05 13.3 0.8 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Ashwin PF15323.6 CDI87903.1 - 0.77 9.8 16.9 0.31 11.0 11.5 2.3 2 0 0 2 2 2 0 Developmental protein NPR3 PF03666.13 CDI87903.1 - 3.8 6.2 10.4 0.31 9.8 3.8 1.9 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 AMP-binding PF00501.28 CDI87904.1 - 0.036 12.7 0.1 0.039 12.5 0.1 1.1 1 0 0 1 1 1 0 AMP-binding enzyme TMEM51 PF15345.6 CDI87904.1 - 0.046 13.6 1.0 0.053 13.3 1.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 NRN1 PF15056.6 CDI87904.1 - 0.055 13.6 3.7 0.67 10.1 3.7 2.1 1 1 1 2 2 2 0 Neuritin protein family BRCT_3 PF18428.1 CDI87904.1 - 0.075 13.1 0.4 0.16 12.0 0.4 1.8 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain TALPID3 PF15324.6 CDI87904.1 - 0.77 7.4 7.5 0.77 7.4 7.5 1.0 1 0 0 1 1 1 0 Hedgehog signalling target Rrp15p PF07890.12 CDI87904.1 - 2.7 8.4 9.6 5.6 7.3 9.6 1.5 1 1 0 1 1 1 0 Rrp15p MscS_TM PF12794.7 CDI87904.1 - 7.6 5.3 5.6 8.6 5.1 5.6 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 GHMP_kinases_N PF00288.26 CDI87907.1 - 0.00074 19.7 6.0 0.48 10.7 0.3 3.1 2 0 0 2 2 2 2 GHMP kinases N terminal domain V_ATPase_I PF01496.19 CDI87909.1 - 0.089 10.7 1.8 0.14 10.0 1.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMEM220 PF15071.6 CDI87909.1 - 0.18 12.6 8.8 0.25 12.1 0.7 2.2 2 0 0 2 2 2 0 Transmembrane family 220, helix Scs3p PF10261.9 CDI87909.1 - 0.33 10.4 1.4 0.52 9.8 1.4 1.3 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Spt20 PF12090.8 CDI87909.1 - 0.6 9.7 29.6 0.13 11.9 18.7 2.2 2 0 0 2 2 2 0 Spt20 family DUF4813 PF16072.5 CDI87909.1 - 1.9 8.1 24.6 0.49 10.0 14.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4813) DUF1180 PF06679.12 CDI87909.1 - 2.3 8.6 16.2 1.8 9.0 14.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) PrgI PF12666.7 CDI87909.1 - 2.6 8.8 6.1 4.8 8.0 1.8 2.2 2 0 0 2 2 2 0 PrgI family protein DUF2339 PF10101.9 CDI87909.1 - 7.6 5.0 28.4 9.2 4.7 28.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) Amnionless PF14828.6 CDI87909.1 - 9.7 4.9 14.9 7.7 5.2 13.6 1.3 1 1 0 1 1 1 0 Amnionless WD40 PF00400.32 CDI87910.1 - 0.00034 21.3 0.0 0.00073 20.3 0.0 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat Activator_LAG-3 PF11498.8 CDI87910.1 - 0.00056 19.0 12.5 0.00091 18.3 12.5 1.4 1 0 0 1 1 1 1 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI87910.1 - 0.059 13.0 17.3 0.1 12.2 17.3 1.4 1 0 0 1 1 1 0 Spt20 family Wzz PF02706.15 CDI87910.1 - 0.095 13.0 6.3 0.26 11.6 6.3 1.8 1 0 0 1 1 1 0 Chain length determinant protein TFIIA PF03153.13 CDI87910.1 - 0.14 12.1 23.6 0.21 11.6 23.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 CDI87910.1 - 0.43 9.4 6.7 0.56 9.0 6.7 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain SR-25 PF10500.9 CDI87910.1 - 0.79 9.3 27.0 0.11 12.1 21.1 2.1 1 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein Secretin_N_2 PF07655.13 CDI87910.1 - 0.96 10.0 14.5 0.31 11.6 9.4 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain CDC45 PF02724.14 CDI87911.1 - 0.45 8.7 48.2 0.64 8.2 48.2 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 CDI87911.1 - 1.3 8.4 47.7 1.8 7.9 47.7 1.2 1 0 0 1 1 1 0 SDA1 SLC12 PF03522.15 CDI87911.1 - 1.7 7.6 55.5 2.2 7.2 55.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 WTX PF09422.10 CDI87911.1 - 5.7 5.9 33.1 7.9 5.4 33.1 1.2 1 0 0 1 1 1 0 WTX protein SAPS PF04499.15 CDI87911.1 - 8.6 5.0 40.8 13 4.4 40.8 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Lin-8 PF03353.15 CDI87915.1 - 0.0038 16.8 33.9 0.12 11.9 13.3 2.2 2 0 0 2 2 2 2 Ras-mediated vulval-induction antagonist RAP1 PF07218.11 CDI87915.1 - 0.049 11.9 7.9 0.059 11.6 7.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Sin_N PF04801.13 CDI87915.1 - 0.075 12.2 41.2 0.24 10.6 25.4 2.2 2 0 0 2 2 2 0 Sin-like protein conserved region SpoIIIAH PF12685.7 CDI87915.1 - 3.9 7.2 34.6 1.2 8.9 3.2 3.2 3 0 0 3 3 3 0 SpoIIIAH-like protein Hid1 PF12722.7 CDI87916.1 - 0.0095 14.1 25.0 0.011 14.0 25.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CDI87916.1 - 0.081 11.7 33.5 0.096 11.4 33.5 1.0 1 0 0 1 1 1 0 Presenilin Miga PF10265.9 CDI87916.1 - 0.18 10.7 11.9 0.19 10.7 11.9 1.0 1 0 0 1 1 1 0 Mitoguardin ALMT PF11744.8 CDI87916.1 - 0.18 10.6 21.9 0.22 10.3 21.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SPX PF03105.19 CDI87916.1 - 0.19 11.6 24.8 0.21 11.4 24.8 1.0 1 0 0 1 1 1 0 SPX domain Lin-8 PF03353.15 CDI87916.1 - 0.19 11.2 30.2 0.23 11.0 30.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist eIF-3_zeta PF05091.12 CDI87916.1 - 0.21 10.5 30.6 0.26 10.2 30.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rtf2 PF04641.12 CDI87916.1 - 0.29 10.5 23.8 0.35 10.2 23.8 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger DUF4045 PF13254.6 CDI87916.1 - 0.49 10.0 21.7 0.55 9.8 21.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PAT1 PF09770.9 CDI87916.1 - 0.55 8.4 47.7 0.61 8.3 47.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 CDI87916.1 - 0.57 10.2 23.3 0.73 9.8 23.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 CDI87916.1 - 0.7 9.7 27.3 0.84 9.4 27.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI87916.1 - 0.73 8.8 29.2 0.83 8.6 29.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF1387 PF07139.11 CDI87916.1 - 0.84 9.3 25.7 1.3 8.7 25.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) HSP70 PF00012.20 CDI87916.1 - 0.86 7.7 15.3 0.95 7.6 15.3 1.0 1 0 0 1 1 1 0 Hsp70 protein SRP-alpha_N PF04086.13 CDI87916.1 - 1.2 9.0 23.3 1.5 8.7 23.3 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CCSAP PF15748.5 CDI87916.1 - 1.8 8.7 32.9 2 8.5 32.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Endostatin PF06482.11 CDI87916.1 - 1.8 7.9 33.8 2.2 7.7 33.8 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CDC45 PF02724.14 CDI87916.1 - 1.8 6.7 24.9 2.1 6.5 24.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Ndc1_Nup PF09531.10 CDI87916.1 - 1.9 7.1 17.1 2.1 6.9 17.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Peptidase_S64 PF08192.11 CDI87916.1 - 2.4 6.5 21.2 2.7 6.4 21.2 1.2 1 0 0 1 1 1 0 Peptidase family S64 PNISR PF15996.5 CDI87916.1 - 2.7 8.2 28.9 3.5 7.9 28.9 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR NPR3 PF03666.13 CDI87916.1 - 3.1 6.5 27.5 3.7 6.2 27.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MCM_bind PF09739.9 CDI87916.1 - 3.1 6.1 25.5 3.6 5.9 25.5 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Dsh_C PF12316.8 CDI87916.1 - 3.6 7.9 20.9 4.3 7.7 20.9 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Dapper PF15268.6 CDI87916.1 - 4 6.2 32.0 4.5 6.0 32.0 1.0 1 0 0 1 1 1 0 Dapper Membralin PF09746.9 CDI87916.1 - 4.1 6.3 20.3 5 6.1 20.3 1.1 1 0 0 1 1 1 0 Tumour-associated protein Bud13 PF09736.9 CDI87916.1 - 4.5 7.7 25.4 6.5 7.1 25.4 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Caldesmon PF02029.15 CDI87916.1 - 4.6 5.9 26.7 5.2 5.7 26.7 1.0 1 0 0 1 1 1 0 Caldesmon AF-4 PF05110.13 CDI87916.1 - 4.9 5.1 41.4 5.7 4.9 41.4 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Plasmodium_Vir PF05795.11 CDI87916.1 - 5.1 6.4 17.4 5.9 6.2 17.4 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein MDM10 PF12519.8 CDI87916.1 - 7.2 5.4 23.8 8.3 5.1 23.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Serinc PF03348.15 CDI87916.1 - 8.7 5.2 15.1 13 4.5 15.1 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Utp14 PF04615.13 CDI87917.1 - 7.2e-06 24.9 46.7 9.5e-06 24.5 46.7 1.1 1 0 0 1 1 1 1 Utp14 protein Dapper PF15268.6 CDI87917.1 - 1.7e-05 23.9 49.2 2.2e-05 23.6 49.2 1.1 1 0 0 1 1 1 1 Dapper Draxin PF15550.6 CDI87917.1 - 0.0015 18.4 27.6 0.0015 18.4 27.6 2.0 2 0 0 2 2 2 1 Draxin MID_MedPIWI PF18296.1 CDI87917.1 - 0.089 12.6 0.1 0.089 12.6 0.1 3.4 1 1 1 2 2 2 0 MID domain of medPIWI SUIM_assoc PF16619.5 CDI87917.1 - 0.25 11.4 0.1 0.25 11.4 0.1 8.9 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 TFIIF_alpha PF05793.12 CDI87917.1 - 0.52 8.8 46.4 0.063 11.9 41.5 1.8 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Hamartin PF04388.12 CDI87917.1 - 0.87 8.2 39.6 0.12 11.0 35.4 1.7 2 0 0 2 2 2 0 Hamartin protein PAT1 PF09770.9 CDI87917.1 - 1.7 6.8 71.3 0.083 11.2 64.0 1.9 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI87917.1 - 4.8 4.2 57.4 0.11 9.6 50.9 1.4 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer GATA PF00320.27 CDI87918.1 - 5.4e-08 32.3 3.2 5.4e-08 32.3 3.2 2.3 2 0 0 2 2 2 1 GATA zinc finger EF-hand_7 PF13499.6 CDI87919.1 - 0.15 12.6 1.4 11 6.6 0.1 2.9 2 1 1 3 3 3 0 EF-hand domain pair RskA PF10099.9 CDI87922.1 - 0.0023 18.3 4.3 0.0023 18.3 4.3 4.2 1 1 1 2 2 2 1 Anti-sigma-K factor rskA Peptidase_S9 PF00326.21 CDI87923.1 - 0.00048 19.7 0.8 0.0006 19.3 0.8 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Spt20 PF12090.8 CDI87923.1 - 0.0034 17.0 15.0 0.0045 16.6 15.0 1.3 1 0 0 1 1 1 1 Spt20 family Med3 PF11593.8 CDI87923.1 - 0.004 16.4 28.7 0.0049 16.1 28.7 1.1 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal TFIIA PF03153.13 CDI87923.1 - 0.0044 17.1 18.8 0.0049 16.9 18.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF4569 PF15133.6 CDI87923.1 - 0.02 14.6 9.3 0.027 14.2 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Med15 PF09606.10 CDI87923.1 - 0.049 12.3 20.4 0.058 12.1 20.4 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Hydin_ADK PF17213.3 CDI87923.1 - 0.057 13.7 9.0 0.063 13.5 9.0 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain FAM60A PF15396.6 CDI87923.1 - 0.11 12.5 3.9 0.15 12.0 3.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A RAB3GAP2_N PF14655.6 CDI87923.1 - 0.12 11.7 4.7 0.15 11.3 4.7 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Tfb4 PF03850.14 CDI87923.1 - 0.21 11.0 5.7 0.3 10.5 5.7 1.2 1 0 0 1 1 1 0 Transcription factor Tfb4 FHIPEP PF00771.20 CDI87923.1 - 0.23 9.9 3.1 0.27 9.6 3.1 1.1 1 0 0 1 1 1 0 FHIPEP family Presenilin PF01080.17 CDI87923.1 - 0.26 10.0 6.1 0.25 10.1 6.1 1.1 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 CDI87923.1 - 0.46 9.5 2.0 0.55 9.2 2.0 1.2 1 0 0 1 1 1 0 CLN3 protein HemX PF04375.14 CDI87923.1 - 0.57 9.4 21.8 0.7 9.1 21.8 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Neur_chan_memb PF02932.16 CDI87923.1 - 0.65 10.0 3.4 0.73 9.9 3.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Roughex PF06020.11 CDI87923.1 - 0.76 8.8 6.6 0.85 8.7 6.6 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Chorion_3 PF05387.11 CDI87923.1 - 1.1 8.8 19.9 1.3 8.6 19.9 1.1 1 0 0 1 1 1 0 Chorion family 3 DUF4179 PF13786.6 CDI87923.1 - 1.4 9.4 13.4 1.8e+02 2.7 13.4 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) Folate_carrier PF01770.18 CDI87923.1 - 1.5 7.4 3.9 2 7.1 3.9 1.1 1 0 0 1 1 1 0 Reduced folate carrier DUF3682 PF12446.8 CDI87923.1 - 3.5 8.1 22.6 5.5 7.5 22.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) RskA PF10099.9 CDI87923.1 - 4 7.7 31.5 5.2e+02 0.8 31.5 2.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA BRF1 PF07741.13 CDI87923.1 - 6.6 7.1 15.6 16 5.9 15.6 1.9 1 1 0 1 1 1 0 Brf1-like TBP-binding domain CPSF73-100_C PF11718.8 CDI87924.1 - 0.13 11.8 3.8 0.22 11.0 3.8 1.5 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term SelP_N PF04592.14 CDI87924.1 - 7.1 5.9 15.7 0.4 10.0 10.4 1.7 2 0 0 2 2 2 0 Selenoprotein P, N terminal region WBP-1 PF11669.8 CDI87924.1 - 7.3 7.3 10.0 41 4.9 0.1 2.8 2 0 0 2 2 2 0 WW domain-binding protein 1 Ribosomal_L18_c PF14204.6 CDI87926.1 - 1.9e-24 86.4 0.1 2.2e-24 86.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region Ribosomal_L5e PF17144.4 CDI87926.1 - 0.066 13.2 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Ribosomal large subunit proteins 60S L5, and 50S L18 Ank_4 PF13637.6 CDI87928.1 - 2.3e-07 31.2 0.0 2.7e-06 27.8 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDI87928.1 - 1.1e-05 25.9 0.3 7.6e-05 23.2 0.0 2.3 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDI87928.1 - 4e-05 23.7 0.0 0.055 14.0 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 CDI87928.1 - 0.0007 19.9 0.0 0.017 15.4 0.0 1.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 CDI87928.1 - 0.0011 19.3 0.0 0.31 11.6 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat DUF2967 PF11179.8 CDI87928.1 - 0.04 12.0 19.7 0.056 11.5 19.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) SAP130_C PF16014.5 CDI87928.1 - 3.5 6.6 9.9 4.1 6.4 9.9 1.1 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus Tic110 PF16940.5 CDI87928.1 - 9.5 4.6 12.6 15 3.9 12.6 1.4 1 0 0 1 1 1 0 Chloroplast envelope transporter SUIM_assoc PF16619.5 CDI87929.1 - 0.28 11.3 7.5 0.81 9.8 5.1 2.8 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI87929.1 - 0.7 9.5 7.8 0.094 12.3 3.8 1.5 2 0 0 2 2 2 0 Spt20 family TFIIA PF03153.13 CDI87930.1 - 0.15 12.0 10.7 0.2 11.6 10.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SWI-SNF_Ssr4 PF08549.10 CDI87930.1 - 0.48 9.0 6.4 0.57 8.7 6.4 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DLIC PF05783.11 CDI87930.1 - 2.7 6.7 6.8 0.38 9.5 2.4 1.8 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) RIFIN PF02009.16 CDI87930.1 - 3.3 7.5 7.0 5.1 6.9 7.0 1.3 1 0 0 1 1 1 0 Rifin Tic110 PF16940.5 CDI87930.1 - 9.7 4.5 17.6 2.2 6.7 8.6 2.1 2 0 0 2 2 2 0 Chloroplast envelope transporter BAF1_ABF1 PF04684.13 CDI87931.1 - 3.8 6.5 31.7 5.4 5.9 31.7 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor TFIIA PF03153.13 CDI87931.1 - 5.2 7.0 42.1 6.3 6.7 42.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Utp14 PF04615.13 CDI87931.1 - 5.5 5.4 45.5 7 5.1 45.5 1.1 1 0 0 1 1 1 0 Utp14 protein AF-4 PF05110.13 CDI87931.1 - 5.9 4.8 43.0 7.7 4.5 43.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PPPI_inhib PF14895.6 CDI87932.1 - 7.5e-05 22.1 0.5 2.2 7.4 0.0 3.9 2 2 1 4 4 4 3 Protein phosphatase 1 inhibitor PDZ_5 PF17817.1 CDI87932.1 - 0.41 11.0 7.8 30 5.0 0.1 4.3 4 0 0 4 4 4 0 PDZ domain AAA_19 PF13245.6 CDI87932.1 - 3.6 7.9 18.8 9.4 6.6 0.2 5.1 3 2 1 5 5 5 0 AAA domain Macoilin PF09726.9 CDI87933.1 - 0.0069 15.0 16.0 0.0073 14.9 16.0 1.1 1 0 0 1 1 1 1 Macoilin family Velvet PF11754.8 CDI87933.1 - 0.022 14.7 7.7 0.024 14.6 7.7 1.0 1 0 0 1 1 1 0 Velvet factor Apt1 PF10351.9 CDI87933.1 - 0.038 12.8 13.3 0.037 12.9 13.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4228 PF14009.6 CDI87933.1 - 0.046 14.1 9.0 0.06 13.7 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) NPR3 PF03666.13 CDI87933.1 - 0.051 12.4 11.0 0.055 12.3 11.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BAF1_ABF1 PF04684.13 CDI87933.1 - 0.059 12.4 10.6 0.068 12.2 10.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CDC45 PF02724.14 CDI87933.1 - 0.067 11.5 6.1 0.073 11.3 6.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 CDI87933.1 - 0.12 11.6 3.5 0.13 11.5 3.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Pneumo_att_G PF05539.11 CDI87933.1 - 0.14 11.7 9.4 0.14 11.7 9.4 1.0 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G TCP PF03634.13 CDI87933.1 - 0.14 12.7 11.4 0.18 12.3 11.4 1.2 1 0 0 1 1 1 0 TCP family transcription factor PI3K_1B_p101 PF10486.9 CDI87933.1 - 0.19 9.5 10.0 0.2 9.4 10.0 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF3807 PF12720.7 CDI87933.1 - 0.27 11.5 8.0 0.35 11.1 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) CAML PF14963.6 CDI87933.1 - 0.4 10.7 4.7 0.42 10.7 4.7 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Presenilin PF01080.17 CDI87933.1 - 0.45 9.2 10.5 0.53 9.0 10.5 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI87933.1 - 0.64 10.0 3.1 0.65 10.0 3.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ORC6 PF05460.13 CDI87933.1 - 0.86 8.8 10.1 1.1 8.5 10.1 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) SOBP PF15279.6 CDI87933.1 - 1.3 9.5 8.5 1.5 9.3 8.5 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF5427 PF10310.9 CDI87933.1 - 1.5 7.7 14.2 1.7 7.5 14.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) THRAP3_BCLAF1 PF15440.6 CDI87933.1 - 1.6 7.7 21.9 1.8 7.4 21.9 1.0 1 0 0 1 1 1 0 THRAP3/BCLAF1 family MAP65_ASE1 PF03999.12 CDI87933.1 - 1.8 7.2 11.5 1.9 7.1 11.5 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Raftlin PF15250.6 CDI87933.1 - 1.8 7.2 7.4 2 7.1 7.4 1.0 1 0 0 1 1 1 0 Raftlin Smg8_Smg9 PF10220.9 CDI87933.1 - 2.2 6.5 9.6 2.6 6.2 9.6 1.0 1 0 0 1 1 1 0 Smg8_Smg9 DUF515 PF04415.12 CDI87933.1 - 3.2 6.1 23.5 4.2 5.7 23.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Sec10 PF07393.11 CDI87933.1 - 3.5 5.9 7.7 3.6 5.9 7.7 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec10 MAP70 PF07058.11 CDI87933.1 - 4.6 5.9 11.2 5.6 5.6 11.2 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 Hid1 PF12722.7 CDI87933.1 - 5.6 5.0 9.0 6.3 4.8 9.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GEMIN8 PF15348.6 CDI87933.1 - 5.7 7.2 9.5 7.3 6.8 9.5 1.1 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 DUF3754 PF12576.8 CDI87934.1 - 0.0066 16.4 2.1 0.0082 16.1 2.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3754) NPDC1 PF06809.11 CDI87934.1 - 0.053 12.6 9.8 0.054 12.5 9.8 1.0 1 0 0 1 1 1 0 Neural proliferation differentiation control-1 protein (NPDC1) DUF2298 PF10060.9 CDI87934.1 - 0.22 10.2 5.1 0.24 10.0 5.1 1.0 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) FAM199X PF15814.5 CDI87934.1 - 0.27 10.2 6.9 0.29 10.1 6.9 1.0 1 0 0 1 1 1 0 Protein family FAM199X TFIIA PF03153.13 CDI87934.1 - 1.6 8.7 17.7 1.6 8.7 17.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI87934.1 - 2.2 7.8 14.2 2.3 7.7 14.2 1.2 1 0 0 1 1 1 0 Spt20 family CCSAP PF15748.5 CDI87935.1 - 0.16 12.1 16.9 0.19 11.9 16.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SR-25 PF10500.9 CDI87935.1 - 0.46 10.1 20.9 0.77 9.3 20.9 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3616 PF12275.8 CDI87935.1 - 0.49 9.8 10.4 0.56 9.6 10.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3616) TCP PF03634.13 CDI87935.1 - 1.4 9.5 16.7 1.6 9.2 16.7 1.1 1 0 0 1 1 1 0 TCP family transcription factor Arv1 PF04161.13 CDI87935.1 - 1.6 8.8 5.8 1.8 8.7 5.8 1.2 1 0 0 1 1 1 0 Arv1-like family Sox_N PF12444.8 CDI87935.1 - 1.8 9.8 11.6 5.8 8.1 5.0 2.2 2 0 0 2 2 2 0 Sox developmental protein N terminal RNA_pol_3_Rpc31 PF11705.8 CDI87935.1 - 2 8.6 7.7 2.4 8.4 7.7 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF2722 PF10846.8 CDI87936.1 - 2.4e-05 23.5 7.3 2.4e-05 23.5 7.3 6.5 3 1 2 5 5 5 2 Protein of unknown function (DUF2722) DOCK_N PF16172.5 CDI87937.1 - 0.09 11.7 0.7 0.1 11.5 0.7 1.1 1 0 0 1 1 1 0 DOCK N-terminus TFIIA PF03153.13 CDI87937.1 - 1.3 9.0 15.0 1.3 8.9 15.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.19 CDI87937.1 - 2.5 8.7 9.0 0.32 11.6 4.9 1.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Hydin_ADK PF17213.3 CDI87938.1 - 0.34 11.2 23.7 0.46 10.7 23.7 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain XRCC4 PF06632.12 CDI87938.1 - 0.69 8.7 17.6 0.84 8.4 17.6 1.0 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 BAF1_ABF1 PF04684.13 CDI87938.1 - 0.8 8.7 23.2 0.96 8.4 23.2 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Macoilin PF09726.9 CDI87938.1 - 0.86 8.1 22.4 1.1 7.8 22.4 1.1 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 CDI87938.1 - 0.9 7.8 16.5 1.1 7.4 16.5 1.0 1 0 0 1 1 1 0 CDC45-like protein ESM4 PF15952.5 CDI87938.1 - 3.6 8.0 26.3 4.7 7.6 26.3 1.1 1 0 0 1 1 1 0 Enhancer of split M4 family Raftlin PF15250.6 CDI87938.1 - 4.4 5.9 20.6 5.1 5.7 20.6 1.0 1 0 0 1 1 1 0 Raftlin Neur_chan_memb PF02932.16 CDI87938.1 - 4.5 7.2 15.9 5.7 6.9 15.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CAC1F_C PF16885.5 CDI87938.1 - 4.8 6.7 15.4 5.8 6.5 15.4 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Presenilin PF01080.17 CDI87938.1 - 4.9 5.8 26.5 5.8 5.6 26.5 1.0 1 0 0 1 1 1 0 Presenilin Rtf2 PF04641.12 CDI87938.1 - 6.3 6.1 17.3 8.5 5.7 17.3 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger RR_TM4-6 PF06459.12 CDI87938.1 - 6.4 6.5 18.2 7.9 6.2 18.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Lin-8 PF03353.15 CDI87938.1 - 7.5 6.0 28.0 11 5.5 28.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Zip PF02535.22 CDI87938.1 - 7.5 5.7 21.7 9.8 5.3 21.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SR-25 PF10500.9 CDI87938.1 - 8.9 5.8 29.7 1.9 8.0 11.1 2.0 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein SMYLE_N PF18615.1 CDI87938.1 - 9.7 5.6 16.4 13 5.3 16.4 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain zf-C2HC_2 PF13913.6 CDI87939.1 - 0.008 16.1 1.8 0.02 14.8 1.8 1.7 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 CDI87939.1 - 0.029 14.8 0.5 0.061 13.8 0.5 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-RING_7 PF02591.15 CDI87939.1 - 0.22 11.7 1.0 1.4 9.1 0.2 2.5 2 0 0 2 2 2 0 C4-type zinc ribbon domain Pkinase PF00069.25 CDI87940.1 - 1.1e-35 123.2 0.0 1.3e-35 123.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI87940.1 - 4.4e-15 55.7 0.0 5.4e-15 55.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDI87940.1 - 0.034 13.5 0.0 0.067 12.5 0.0 1.6 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RskA PF10099.9 CDI87941.1 - 8.6e-05 22.9 12.0 0.0002 21.7 12.0 1.6 1 1 0 1 1 1 1 Anti-sigma-K factor rskA Roughex PF06020.11 CDI87941.1 - 0.00067 18.9 11.3 0.00097 18.3 11.3 1.4 1 0 0 1 1 1 1 Drosophila roughex protein AAA_23 PF13476.6 CDI87941.1 - 0.0092 16.5 23.5 0.012 16.1 23.5 1.1 1 0 0 1 1 1 1 AAA domain Spt5_N PF11942.8 CDI87941.1 - 0.016 16.2 21.5 0.029 15.4 21.5 1.4 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal DUF1682 PF07946.14 CDI87941.1 - 0.017 14.4 9.8 0.022 14.0 9.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) SDA1 PF05285.12 CDI87941.1 - 0.018 14.5 18.3 0.023 14.1 18.3 1.2 1 0 0 1 1 1 0 SDA1 DUF2052 PF09747.9 CDI87941.1 - 0.038 14.1 20.4 0.046 13.8 20.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) TFIIA PF03153.13 CDI87941.1 - 0.12 12.4 40.7 0.16 11.9 40.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BAF1_ABF1 PF04684.13 CDI87941.1 - 0.13 11.3 28.4 0.18 10.8 28.4 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor NARP1 PF12569.8 CDI87941.1 - 0.6 9.0 16.2 0.71 8.7 16.2 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4175 PF13779.6 CDI87941.1 - 0.71 7.7 34.1 0.76 7.6 34.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4746 PF15928.5 CDI87941.1 - 0.72 9.2 16.1 0.91 8.9 16.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF2126 PF09899.9 CDI87941.1 - 0.81 7.7 10.6 0.83 7.6 10.6 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) TERB2 PF15101.6 CDI87941.1 - 1.4 9.0 30.5 0.45 10.5 27.8 1.6 1 1 1 2 2 2 0 Telomere-associated protein TERB2 DUF5523 PF17661.1 CDI87941.1 - 1.7 8.3 23.5 2.3 7.9 23.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Usp PF00582.26 CDI87941.1 - 2.4 8.7 6.2 3.9 8.0 6.2 1.3 1 0 0 1 1 1 0 Universal stress protein family PA26 PF04636.13 CDI87941.1 - 2.5 6.9 16.7 3.2 6.6 16.7 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Peptidase_S49_N PF08496.10 CDI87941.1 - 3.8 7.6 15.2 7 6.7 15.2 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4407 PF14362.6 CDI87941.1 - 5.5 6.3 17.7 6.3 6.1 17.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hid1 PF12722.7 CDI87941.1 - 7.6 4.5 31.9 9.1 4.3 31.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Spt20 PF12090.8 CDI87942.1 - 0.0064 16.1 38.1 0.0067 16.1 38.1 1.0 1 0 0 1 1 1 1 Spt20 family Cgr1 PF03879.14 CDI87942.1 - 0.068 13.5 18.8 0.078 13.4 18.8 1.1 1 0 0 1 1 1 0 Cgr1 family Med15 PF09606.10 CDI87942.1 - 0.49 9.0 24.0 0.52 8.9 24.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2722 PF10846.8 CDI87942.1 - 0.71 8.7 28.7 0.76 8.7 28.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF3371 PF11851.8 CDI87942.1 - 0.96 10.5 13.8 1 10.4 13.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) TFIIA PF03153.13 CDI87942.1 - 2.8 7.8 32.4 2.9 7.8 32.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit HNOBA PF07701.14 CDI87942.1 - 4 6.8 13.4 4.6 6.6 13.4 1.2 1 0 0 1 1 1 0 Heme NO binding associated DUF4820 PF16091.5 CDI87942.1 - 4.9 6.5 14.9 5.8 6.2 14.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) PepSY_TM PF03929.16 CDI87942.1 - 9.4 5.8 8.8 9.7 5.8 8.8 1.0 1 0 0 1 1 1 0 PepSY-associated TM region DUF853 PF05872.12 CDI87942.1 - 9.6 4.7 12.9 10 4.6 12.9 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) ketoacyl-synt PF00109.26 CDI87944.1 - 5.2e-79 265.4 0.5 5.2e-79 265.4 0.5 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.28 CDI87944.1 - 8e-75 252.0 0.0 1.9e-74 250.8 0.0 1.7 1 1 0 1 1 1 1 AMP-binding enzyme PS-DH PF14765.6 CDI87944.1 - 6.7e-42 143.7 0.0 3.6e-31 108.5 0.0 2.3 2 0 0 2 2 2 2 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CDI87944.1 - 8.2e-41 138.7 0.0 2e-40 137.5 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 CDI87944.1 - 1.7e-22 80.4 0.0 2.8e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain PP-binding PF00550.25 CDI87944.1 - 2.7e-11 43.6 0.3 8.1e-11 42.1 0.3 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CDI87944.1 - 5.3e-09 36.5 0.0 1.8e-08 34.8 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_N PF08240.12 CDI87944.1 - 2.2e-06 27.5 0.0 7.7e-06 25.7 0.0 2.0 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CDI87944.1 - 4e-05 24.7 0.0 0.00027 22.0 0.0 2.4 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Thiolase_N PF00108.23 CDI87944.1 - 0.00018 21.0 1.8 0.00021 20.7 0.2 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain AMP-binding_C_2 PF14535.6 CDI87944.1 - 0.0019 18.5 0.0 0.0053 17.1 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACP_syn_III PF08545.10 CDI87944.1 - 0.1 12.4 0.8 0.29 11.0 0.3 2.0 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III HEAT PF02985.22 CDI87945.1 - 0.0025 17.9 0.9 0.032 14.5 0.0 3.5 3 0 0 3 3 3 1 HEAT repeat SR-25 PF10500.9 CDI87945.1 - 0.0062 16.2 5.3 0.0062 16.2 5.3 3.6 4 0 0 4 4 4 1 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI87945.1 - 0.0073 16.3 10.4 0.0097 16.0 10.4 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF3446 PF11928.8 CDI87945.1 - 0.013 15.8 5.4 0.013 15.8 5.4 4.4 3 1 0 4 4 4 0 Early growth response N-terminal domain Lin-8 PF03353.15 CDI87945.1 - 0.32 10.5 4.4 0.3 10.6 0.9 2.0 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist SRP-alpha_N PF04086.13 CDI87946.1 - 2 8.3 55.6 2.4 8.0 55.6 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Pex24p PF06398.11 CDI87947.1 - 1.5e-05 24.2 2.1 1.8e-05 23.9 2.1 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin SID-1_RNA_chan PF13965.6 CDI87947.1 - 4.8e-05 22.0 3.1 5.4e-05 21.8 3.1 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DUF4131 PF13567.6 CDI87947.1 - 7.5e-05 22.4 4.9 8.1e-05 22.3 4.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) DUF4834 PF16118.5 CDI87947.1 - 0.00011 23.1 17.7 0.00021 22.2 17.7 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4834) CBP_BcsG PF11658.8 CDI87947.1 - 0.00015 20.4 9.8 0.00016 20.2 9.8 1.0 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG V_ATPase_I PF01496.19 CDI87947.1 - 0.00028 19.0 15.0 0.00033 18.8 15.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI87947.1 - 0.0003 20.0 9.4 0.00035 19.8 9.4 1.0 1 0 0 1 1 1 1 CLN3 protein DUF2244 PF10003.9 CDI87947.1 - 0.00031 20.4 0.2 0.00036 20.2 0.2 1.1 1 0 0 1 1 1 1 Integral membrane protein (DUF2244) O-antigen_lig PF13425.6 CDI87947.1 - 0.00089 18.2 4.6 0.001 17.9 4.6 1.1 1 0 0 1 1 1 1 O-antigen ligase like membrane protein Peptidase_S49_N PF08496.10 CDI87947.1 - 0.0009 19.3 11.1 0.0012 19.0 11.1 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal Nucleoside_tran PF01733.18 CDI87947.1 - 0.0011 18.4 2.0 0.0013 18.2 2.0 1.2 1 0 0 1 1 1 1 Nucleoside transporter SARAF PF06682.12 CDI87947.1 - 0.0016 18.2 3.4 0.0019 17.9 3.4 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Neur_chan_memb PF02932.16 CDI87947.1 - 0.002 18.2 8.1 0.0026 17.8 8.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region FA_desaturase PF00487.24 CDI87947.1 - 0.0027 17.6 0.1 0.0028 17.5 0.1 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Wzy_C PF04932.15 CDI87947.1 - 0.0029 17.3 0.0 0.0034 17.0 0.0 1.2 1 0 0 1 1 1 1 O-Antigen ligase G0-G1_switch_2 PF15103.6 CDI87947.1 - 0.0076 16.7 4.9 0.0097 16.3 4.9 1.2 1 0 0 1 1 1 1 G0/G1 switch protein 2 YfhO PF09586.10 CDI87947.1 - 0.0078 14.5 12.6 0.009 14.3 12.6 1.1 1 0 0 1 1 1 1 Bacterial membrane protein YfhO Choline_transpo PF04515.12 CDI87947.1 - 0.008 15.4 0.1 0.0085 15.3 0.1 1.1 1 0 0 1 1 1 1 Plasma-membrane choline transporter LRR19-TM PF15176.6 CDI87947.1 - 0.01 15.8 1.3 0.014 15.4 1.3 1.3 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain SpoIIP PF07454.11 CDI87947.1 - 0.01 15.3 8.0 0.011 15.2 8.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CSG2 PF16965.5 CDI87947.1 - 0.012 14.6 5.9 0.013 14.4 5.9 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator POPLD PF08170.12 CDI87947.1 - 0.013 15.8 6.5 0.016 15.5 6.5 1.1 1 0 0 1 1 1 0 POPLD (NUC188) domain PRA1 PF03208.19 CDI87947.1 - 0.018 14.7 3.0 0.021 14.5 3.0 1.1 1 0 0 1 1 1 0 PRA1 family protein SKN1 PF03935.15 CDI87947.1 - 0.021 13.2 3.9 0.025 13.0 3.9 1.0 1 0 0 1 1 1 0 Beta-glucan synthesis-associated protein (SKN1) MMM1 PF10296.9 CDI87947.1 - 0.023 13.8 5.6 0.026 13.6 5.6 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 DUF5313 PF17240.2 CDI87947.1 - 0.026 14.9 10.6 0.032 14.7 10.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5313) CitMHS PF03600.16 CDI87947.1 - 0.029 13.6 0.2 0.03 13.5 0.2 1.1 1 0 0 1 1 1 0 Citrate transporter DDHD PF02862.17 CDI87947.1 - 0.029 14.5 5.8 0.032 14.4 5.8 1.1 1 0 0 1 1 1 0 DDHD domain DUF3810 PF12725.7 CDI87947.1 - 0.029 13.7 3.8 0.034 13.5 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) PIP5K PF01504.18 CDI87947.1 - 0.034 13.4 6.2 0.038 13.2 6.2 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Folate_carrier PF01770.18 CDI87947.1 - 0.04 12.7 9.6 0.048 12.4 9.6 1.0 1 0 0 1 1 1 0 Reduced folate carrier RskA PF10099.9 CDI87947.1 - 0.065 13.5 7.6 0.12 12.7 7.6 1.5 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF2828 PF11443.8 CDI87947.1 - 0.066 11.3 9.1 0.073 11.1 9.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) ArAE_2_N PF10337.9 CDI87947.1 - 0.093 11.7 12.9 0.12 11.4 12.9 1.3 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal CobD_Cbib PF03186.13 CDI87947.1 - 0.12 11.6 1.7 0.12 11.5 1.7 1.1 1 0 0 1 1 1 0 CobD/Cbib protein CobT PF06213.12 CDI87947.1 - 0.12 11.8 13.7 0.13 11.6 13.7 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DcuA_DcuB PF03605.14 CDI87947.1 - 0.14 11.0 5.8 0.17 10.7 5.8 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF4010 PF13194.6 CDI87947.1 - 0.16 11.6 7.0 0.21 11.2 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) Baculo_PP31 PF05311.11 CDI87947.1 - 0.2 11.1 8.6 0.22 11.0 8.6 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) CPSF100_C PF13299.6 CDI87947.1 - 0.21 11.8 7.5 0.25 11.5 7.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal NEMP PF10225.9 CDI87947.1 - 0.32 10.6 8.8 0.39 10.4 8.8 1.1 1 0 0 1 1 1 0 NEMP family Band_3_cyto PF07565.13 CDI87947.1 - 0.46 10.3 17.1 0.56 10.0 17.1 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Gastrin PF00918.17 CDI87947.1 - 0.47 11.4 10.8 0.55 11.2 10.8 1.1 1 0 0 1 1 1 0 Gastrin/cholecystokinin family R_equi_Vir PF05526.11 CDI87947.1 - 0.54 10.1 3.3 0.64 9.9 3.3 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein HemX PF04375.14 CDI87947.1 - 0.58 9.4 30.6 0.69 9.1 30.6 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Mem_trans PF03547.18 CDI87947.1 - 0.73 8.2 9.6 0.91 7.8 9.6 1.2 1 0 0 1 1 1 0 Membrane transport protein DUF2254 PF10011.9 CDI87947.1 - 0.93 8.2 10.4 1.3 7.8 10.4 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2254) Endonuc_Holl PF10107.9 CDI87947.1 - 1.1 9.1 13.3 1.4 8.8 13.3 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Sigma_reg_N PF13800.6 CDI87947.1 - 1.4 9.3 5.8 2 8.7 5.8 1.5 1 1 0 1 1 1 0 Sigma factor regulator N-terminal OATP PF03137.20 CDI87947.1 - 1.5 7.0 12.0 0.62 8.3 10.2 1.3 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Stig1 PF04885.13 CDI87947.1 - 2.2 8.8 10.0 2.6 8.5 10.0 1.1 1 0 0 1 1 1 0 Stigma-specific protein, Stig1 Comm PF15957.5 CDI87947.1 - 2.9 8.2 9.3 7 7.0 9.3 1.8 1 1 0 1 1 1 0 Commissureless AIF_C PF14721.6 CDI87947.1 - 3.4 8.0 9.8 4.3 7.7 9.8 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FAM176 PF14851.6 CDI87947.1 - 4.4 7.0 13.8 6.7 6.4 13.8 1.4 1 1 0 1 1 1 0 FAM176 family PIG-P PF08510.12 CDI87947.1 - 4.7 7.1 8.5 23 4.9 8.5 1.9 1 1 0 1 1 1 0 PIG-P YABBY PF04690.13 CDI87947.1 - 6.3 7.4 13.9 7.7 7.1 13.9 1.1 1 0 0 1 1 1 0 YABBY protein RXLR PF16810.5 CDI87947.1 - 6.5 7.2 11.1 0.079 13.4 4.0 1.5 1 1 1 2 2 1 0 RXLR phytopathogen effector protein, Avirulence activity DUF3742 PF12553.8 CDI87947.1 - 7.4 6.7 6.1 17 5.6 6.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3742) Tim54 PF11711.8 CDI87947.1 - 7.5 5.2 12.8 9 5.0 12.8 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 ALMT PF11744.8 CDI87947.1 - 7.8 5.2 10.7 8.9 5.0 10.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2140 PF09911.9 CDI87947.1 - 9.4 5.7 16.4 15 5.0 16.4 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) Connexin PF00029.19 CDI87947.1 - 9.8 5.9 20.8 5.4 6.7 19.1 1.5 1 1 1 2 2 2 0 Connexin Peptidase_M41 PF01434.18 CDI87948.1 - 1.1e-08 35.1 0.1 1.1e-08 35.1 0.1 2.5 3 0 0 3 3 3 1 Peptidase family M41 Calici_coat_C PF08435.11 CDI87948.1 - 0.45 10.0 4.2 0.56 9.7 3.8 1.3 1 1 0 1 1 1 0 Calicivirus coat protein C-terminal SR-25 PF10500.9 CDI87948.1 - 0.93 9.1 42.1 0.067 12.8 9.6 2.7 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI87948.1 - 1.6 8.6 24.9 3.1 7.7 24.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DALR_2 PF09190.11 CDI87949.1 - 0.81 10.2 5.2 3.8 8.1 0.4 2.8 2 1 0 2 2 2 0 DALR domain RAMP4 PF06624.12 CDI87950.1 - 0.0019 18.2 1.0 0.0053 16.8 0.1 2.2 2 1 0 2 2 2 1 Ribosome associated membrane protein RAMP4 INSIG PF07281.12 CDI87950.1 - 0.0028 17.3 0.2 0.0028 17.3 0.2 2.0 1 1 1 2 2 2 1 Insulin-induced protein (INSIG) GET2 PF08690.10 CDI87950.1 - 0.021 14.5 24.2 0.027 14.1 24.2 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 BAF1_ABF1 PF04684.13 CDI87950.1 - 0.036 13.1 17.8 0.044 12.9 17.8 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor RskA PF10099.9 CDI87950.1 - 0.041 14.2 20.5 0.045 14.0 19.6 1.4 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Presenilin PF01080.17 CDI87950.1 - 0.22 10.2 20.8 0.27 10.0 20.8 1.1 1 0 0 1 1 1 0 Presenilin CrgA PF06781.12 CDI87950.1 - 1.1 9.4 3.9 1.8 8.6 0.2 2.3 1 1 0 2 2 2 0 Cell division protein CrgA Trp_oprn_chp PF09534.10 CDI87950.1 - 2 8.2 7.7 1.3 8.8 1.7 2.0 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2076 PF09849.9 CDI87950.1 - 2.2 8.3 39.9 2.6 8.0 39.9 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF2157 PF09925.9 CDI87950.1 - 2.3 8.0 6.9 0.91 9.3 0.2 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) CAF1 PF04857.20 CDI87950.1 - 2.4 7.2 11.3 3 6.9 11.3 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease DUF572 PF04502.13 CDI87950.1 - 2.5 7.6 17.0 3.6 7.1 17.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Dala_Dala_lig_N PF01820.21 CDI87950.1 - 2.5 8.6 5.5 13 6.3 5.5 2.0 1 1 0 1 1 1 0 D-ala D-ala ligase N-terminus DUF4366 PF14283.6 CDI87950.1 - 3.8 7.6 11.2 21 5.1 11.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) MRP-S31 PF15433.6 CDI87950.1 - 3.8 7.1 21.8 4.7 6.8 21.8 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 SPT6_acidic PF14632.6 CDI87950.1 - 4.7 7.9 13.4 1.7 9.3 2.8 2.2 2 0 0 2 2 2 0 Acidic N-terminal SPT6 DDHD PF02862.17 CDI87950.1 - 5 7.2 18.0 8.4 6.5 18.0 1.3 1 0 0 1 1 1 0 DDHD domain MDFI PF15316.6 CDI87950.1 - 6 6.9 15.9 7.2 6.7 15.9 1.2 1 0 0 1 1 1 0 MyoD family inhibitor V_ATPase_I PF01496.19 CDI87950.1 - 7.1 4.4 20.3 9.1 4.1 20.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family THOC2_N PF16134.5 CDI87950.1 - 7.5 5.0 17.9 2.5 6.6 15.1 1.5 1 1 1 2 2 2 0 THO complex subunit 2 N-terminus Neur_chan_memb PF02932.16 CDI87950.1 - 9 6.3 16.9 13 5.8 16.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TssO PF17561.2 CDI87950.1 - 9 6.4 18.8 0.46 10.6 4.1 2.4 2 0 0 2 2 2 0 Type VI secretion system, TssO DcuA_DcuB PF03605.14 CDI87950.1 - 9.5 5.0 14.7 0.057 12.3 1.8 2.0 1 1 1 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter FAM176 PF14851.6 CDI87951.1 - 0.0018 18.0 7.0 0.002 17.8 7.0 1.1 1 0 0 1 1 1 1 FAM176 family DUF4834 PF16118.5 CDI87951.1 - 0.012 16.6 4.5 0.014 16.3 4.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CobT PF06213.12 CDI87951.1 - 0.033 13.6 18.9 0.037 13.4 18.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 CDI87951.1 - 0.052 13.7 9.7 0.061 13.5 9.7 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2828 PF11443.8 CDI87951.1 - 0.058 11.5 5.7 0.061 11.4 5.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF2722 PF10846.8 CDI87951.1 - 0.1 11.5 19.2 0.12 11.3 19.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Connexin PF00029.19 CDI87951.1 - 0.12 12.1 4.3 0.12 12.2 4.3 1.1 1 0 0 1 1 1 0 Connexin MAP17 PF15807.5 CDI87951.1 - 0.12 12.6 5.1 0.15 12.3 5.1 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Suf PF05843.14 CDI87951.1 - 0.14 12.2 7.2 0.15 12.0 7.2 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CCSAP PF15748.5 CDI87951.1 - 0.16 12.1 11.9 0.18 12.0 11.9 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated REC114-like PF15165.6 CDI87951.1 - 0.19 11.5 7.6 0.21 11.4 7.6 1.0 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like TRAP_alpha PF03896.16 CDI87951.1 - 0.19 10.9 9.6 0.2 10.9 9.6 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SID-1_RNA_chan PF13965.6 CDI87951.1 - 0.24 9.8 4.7 0.24 9.8 4.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Androgen_recep PF02166.16 CDI87951.1 - 0.25 10.1 9.4 0.26 10.1 9.4 1.1 1 0 0 1 1 1 0 Androgen receptor Pex14_N PF04695.13 CDI87951.1 - 0.28 11.8 9.5 0.33 11.6 9.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3391 PF11871.8 CDI87951.1 - 0.29 11.7 11.0 0.34 11.4 11.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) Ureide_permease PF07168.11 CDI87951.1 - 0.29 9.8 3.6 0.29 9.8 3.6 1.0 1 0 0 1 1 1 0 Ureide permease SDA1 PF05285.12 CDI87951.1 - 0.3 10.5 19.8 0.31 10.4 19.8 1.0 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 CDI87951.1 - 0.31 9.3 14.2 0.34 9.2 14.2 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF5308 PF17233.2 CDI87951.1 - 0.31 11.2 6.5 0.37 11.0 6.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) PIP5K PF01504.18 CDI87951.1 - 0.34 10.1 5.2 0.37 10.0 5.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Spt20 PF12090.8 CDI87951.1 - 0.36 10.4 19.3 0.41 10.2 19.3 1.0 1 0 0 1 1 1 0 Spt20 family Spore_III_AF PF09581.10 CDI87951.1 - 0.37 10.8 8.1 0.37 10.8 8.1 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) DUF5523 PF17661.1 CDI87951.1 - 0.41 10.3 16.4 0.44 10.2 16.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF913 PF06025.12 CDI87951.1 - 0.46 9.4 9.5 0.5 9.3 9.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CLN3 PF02487.17 CDI87951.1 - 0.49 9.4 4.7 0.48 9.4 4.7 1.0 1 0 0 1 1 1 0 CLN3 protein V_ATPase_I PF01496.19 CDI87951.1 - 0.61 7.9 7.4 0.58 8.0 7.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Coilin_N PF15862.5 CDI87951.1 - 0.64 9.8 11.2 0.79 9.5 11.2 1.2 1 0 0 1 1 1 0 Coilin N-terminus XAP5 PF04921.14 CDI87951.1 - 0.76 9.6 11.8 0.83 9.4 11.8 1.0 1 0 0 1 1 1 0 XAP5, circadian clock regulator TLP-20 PF06088.11 CDI87951.1 - 0.77 9.6 7.5 0.94 9.4 7.5 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Ctr PF04145.15 CDI87951.1 - 0.78 10.3 1.6 0.82 10.3 1.6 1.1 1 0 0 1 1 1 0 Ctr copper transporter family DUF4820 PF16091.5 CDI87951.1 - 0.83 9.0 10.8 0.95 8.8 10.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Roughex PF06020.11 CDI87951.1 - 0.83 8.7 19.7 0.95 8.5 19.7 1.0 1 0 0 1 1 1 0 Drosophila roughex protein CBP_BcsG PF11658.8 CDI87951.1 - 0.84 8.0 5.7 0.89 7.9 5.7 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG SpoIIP PF07454.11 CDI87951.1 - 0.87 9.0 11.6 0.9 8.9 11.6 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CDI87951.1 - 1 8.0 11.9 1.1 7.9 11.9 1.0 1 0 0 1 1 1 0 Presenilin FHIPEP PF00771.20 CDI87951.1 - 1.2 7.5 5.3 1.1 7.6 5.3 1.0 1 0 0 1 1 1 0 FHIPEP family EIIBC-GUT_N PF03612.14 CDI87951.1 - 1.2 8.8 7.6 1.4 8.6 7.6 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TERB2 PF15101.6 CDI87951.1 - 1.3 9.0 11.6 1.4 8.9 11.6 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 EOS1 PF12326.8 CDI87951.1 - 1.3 8.9 3.6 1.5 8.8 3.6 1.1 1 0 0 1 1 1 0 N-glycosylation protein SAPS PF04499.15 CDI87951.1 - 1.3 7.7 13.5 1.6 7.4 13.5 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein FAM60A PF15396.6 CDI87951.1 - 1.3 8.9 8.3 1.5 8.7 8.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Tim54 PF11711.8 CDI87951.1 - 1.6 7.5 12.8 1.6 7.4 12.8 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Spore_coat_CotO PF14153.6 CDI87951.1 - 1.6 8.6 18.1 1.9 8.4 18.1 1.1 1 0 0 1 1 1 0 Spore coat protein CotO CSG2 PF16965.5 CDI87951.1 - 1.7 7.5 3.5 1.8 7.4 3.5 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator RR_TM4-6 PF06459.12 CDI87951.1 - 2 8.2 14.4 2.2 8.0 14.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 CDI87951.1 - 2 8.5 9.0 2 8.5 9.0 1.1 1 0 0 1 1 1 0 DDHD domain MCU PF04678.13 CDI87951.1 - 2.1 8.4 7.0 2.2 8.3 7.0 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Neur_chan_memb PF02932.16 CDI87951.1 - 2.2 8.3 5.6 2.3 8.2 5.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 CDI87951.1 - 2.7 6.0 11.2 3 5.9 11.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pannexin_like PF12534.8 CDI87951.1 - 3.1 6.8 5.4 3 6.9 5.4 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Sec62 PF03839.16 CDI87951.1 - 3.1 7.2 7.5 3.5 7.1 7.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 TFB6 PF17110.5 CDI87951.1 - 3.3 7.4 11.1 4.2 7.1 11.1 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH ALMT PF11744.8 CDI87951.1 - 3.4 6.4 5.7 3.4 6.4 5.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Gti1_Pac2 PF09729.9 CDI87951.1 - 3.6 7.6 9.2 4.1 7.4 9.2 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family UPF0560 PF10577.9 CDI87951.1 - 4.7 5.6 10.9 4.8 5.5 10.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PTPRCAP PF15713.5 CDI87951.1 - 5.3 7.3 19.2 6.2 7.1 19.2 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated NPR3 PF03666.13 CDI87951.1 - 6.1 5.5 12.5 6.8 5.4 12.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ATP-synt_E PF05680.12 CDI87951.1 - 7.9 6.9 12.1 9.3 6.7 12.1 1.3 1 0 0 1 1 1 0 ATP synthase E chain Serinc PF03348.15 CDI87951.1 - 8.3 5.2 6.4 8 5.3 6.4 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) RNA_pol_Rpc4 PF05132.14 CDI87951.1 - 8.6 6.8 14.0 11 6.4 14.0 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Consortin_C PF15281.6 CDI87952.1 - 0.39 10.7 0.0 0.39 10.7 0.0 2.0 3 0 0 3 3 3 0 Consortin C-terminus ROS_MUCR PF05443.11 CDI87952.1 - 0.61 10.1 4.6 0.19 11.8 0.7 2.1 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein Spt20 PF12090.8 CDI87953.1 - 0.0086 15.7 16.8 0.0086 15.7 16.8 3.9 3 1 1 4 4 4 2 Spt20 family DUF485 PF04341.12 CDI87953.1 - 0.01 15.8 0.7 0.1 12.5 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF485 Presenilin PF01080.17 CDI87953.1 - 1.7 7.3 17.8 0.73 8.5 7.1 2.5 2 0 0 2 2 2 0 Presenilin DUF572 PF04502.13 CDI87953.1 - 1.9 8.0 21.7 0.34 10.5 9.6 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF572) OATP PF03137.20 CDI87953.1 - 2.7 6.2 7.8 0.098 10.9 0.3 2.1 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Adaptin_binding PF10199.9 CDI87953.1 - 3.2 8.4 18.9 12 6.6 1.4 2.7 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 DUF3306 PF11748.8 CDI87954.1 - 0.0031 18.4 0.6 0.0038 18.1 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3306) WD40 PF00400.32 CDI87956.1 - 5.2e-05 23.9 5.0 0.13 13.2 0.3 4.0 3 0 0 3 3 3 2 WD domain, G-beta repeat XRCC4 PF06632.12 CDI87956.1 - 0.018 13.9 0.9 0.05 12.5 0.9 1.7 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF1598 PF07643.11 CDI87956.1 - 0.074 13.3 0.1 1.5 9.1 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1598) TPR_14 PF13428.6 CDI87956.1 - 0.46 11.4 9.9 29 5.9 0.8 5.7 4 1 0 4 4 4 0 Tetratricopeptide repeat SUIM_assoc PF16619.5 CDI87957.1 - 0.015 15.3 2.3 0.026 14.6 2.3 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI87957.1 - 0.4 11.0 19.4 0.21 11.9 13.8 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA SLC12 PF03522.15 CDI87958.1 - 7.9 5.4 5.8 12 4.8 5.8 1.3 1 0 0 1 1 1 0 Solute carrier family 12 LETM1 PF07766.13 CDI87959.1 - 0.0097 15.3 0.9 0.011 15.1 0.9 1.1 1 0 0 1 1 1 1 LETM1-like protein DUF2722 PF10846.8 CDI87959.1 - 0.019 13.9 6.7 0.024 13.6 6.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Myc_N PF01056.18 CDI87959.1 - 0.077 12.9 4.3 0.089 12.7 4.3 1.0 1 0 0 1 1 1 0 Myc amino-terminal region TFIIA PF03153.13 CDI87959.1 - 0.08 12.9 16.4 0.1 12.6 16.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3854 PF12965.7 CDI87959.1 - 0.15 12.0 1.0 0.19 11.7 0.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3854) Ric8 PF10165.9 CDI87959.1 - 0.22 10.5 6.0 0.14 11.2 4.5 1.2 1 1 0 1 1 1 0 Guanine nucleotide exchange factor synembryn UPF0565 PF10561.9 CDI87959.1 - 1.4 8.0 4.8 1.9 7.6 4.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Ndc1_Nup PF09531.10 CDI87959.1 - 4.2 5.9 10.6 4.8 5.8 10.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SUIM_assoc PF16619.5 CDI87959.1 - 4.6 7.4 23.4 9 6.4 21.4 2.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF5523 PF17661.1 CDI87961.1 - 1.1 8.9 25.9 1.5 8.4 25.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Presenilin PF01080.17 CDI87961.1 - 2.6 6.7 35.4 2.8 6.6 35.4 1.0 1 0 0 1 1 1 0 Presenilin DUF4050 PF13259.6 CDI87961.1 - 2.7 8.3 24.5 3.9 7.8 24.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) RMP PF14996.6 CDI87961.1 - 4.2 7.6 28.9 0.81 9.9 15.6 2.0 1 1 1 2 2 2 0 Retinal Maintenance DUF2052 PF09747.9 CDI87961.1 - 9.1 6.4 28.6 10 6.2 28.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Ldh_1_N PF00056.23 CDI87962.1 - 2.6e-14 53.5 1.4 3.1e-14 53.3 1.4 1.0 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CDI87962.1 - 0.014 14.4 0.2 0.015 14.4 0.2 1.0 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.17 CDI87962.1 - 0.13 12.9 1.5 0.21 12.2 1.5 1.4 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent RskA PF10099.9 CDI87963.1 - 8.8e-05 22.9 21.1 0.00014 22.3 21.1 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA BAF1_ABF1 PF04684.13 CDI87963.1 - 0.012 14.7 15.8 0.014 14.4 15.8 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Pinin_SDK_memA PF04696.13 CDI87963.1 - 0.013 15.6 21.8 0.13 12.3 1.4 2.1 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region CAF1 PF04857.20 CDI87963.1 - 0.029 13.5 9.3 0.035 13.3 9.3 1.0 1 0 0 1 1 1 0 CAF1 family ribonuclease PIP5K PF01504.18 CDI87963.1 - 0.059 12.6 7.9 0.07 12.3 7.9 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Rtf2 PF04641.12 CDI87963.1 - 0.065 12.6 12.5 0.084 12.2 12.5 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger PEX11 PF05648.14 CDI87963.1 - 0.12 11.8 15.8 0.61 9.5 1.0 2.0 1 1 1 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) DivIC PF04977.15 CDI87963.1 - 0.15 11.8 26.3 1.1 9.1 3.7 2.2 2 0 0 2 2 2 0 Septum formation initiator PA26 PF04636.13 CDI87963.1 - 0.16 10.8 12.9 0.18 10.7 12.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PXA PF02194.15 CDI87963.1 - 0.18 11.8 7.1 0.28 11.1 7.1 1.3 1 0 0 1 1 1 0 PXA domain TFIIA PF03153.13 CDI87963.1 - 0.19 11.7 44.4 0.32 10.9 44.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2828 PF11443.8 CDI87963.1 - 0.22 9.6 14.0 0.27 9.3 14.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Presenilin PF01080.17 CDI87963.1 - 0.22 10.2 17.6 0.27 10.0 17.6 1.1 1 0 0 1 1 1 0 Presenilin 7tm_1 PF00001.21 CDI87963.1 - 0.24 10.7 3.2 0.33 10.2 3.2 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) AGO_N PF18236.1 CDI87963.1 - 0.24 11.6 6.2 3.8 7.8 0.2 2.1 2 0 0 2 2 2 0 Argonaute N domain DUF4048 PF13257.6 CDI87963.1 - 0.25 11.1 16.8 0.32 10.8 16.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4048) SID-1_RNA_chan PF13965.6 CDI87963.1 - 0.31 9.4 8.1 0.36 9.2 8.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4386 PF14329.6 CDI87963.1 - 0.49 10.2 5.0 0.72 9.7 5.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) O-antigen_lig PF13425.6 CDI87963.1 - 0.54 9.0 4.6 0.61 8.8 4.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Gti1_Pac2 PF09729.9 CDI87963.1 - 0.83 9.7 12.3 1.2 9.2 12.3 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Hydin_ADK PF17213.3 CDI87963.1 - 1 9.6 18.7 1.3 9.3 18.7 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Conotoxin PF02950.17 CDI87963.1 - 1.4 9.9 11.5 2.6 9.1 3.8 2.4 2 0 0 2 2 2 0 Conotoxin CD20 PF04103.15 CDI87963.1 - 1.4 8.9 6.1 0.28 11.3 0.7 1.9 1 1 1 2 2 2 0 CD20-like family FHIPEP PF00771.20 CDI87963.1 - 1.5 7.2 16.6 2.7 6.3 16.6 1.4 1 1 0 1 1 1 0 FHIPEP family MIIP PF15734.5 CDI87963.1 - 1.5 8.2 15.9 1.8 7.9 15.9 1.0 1 0 0 1 1 1 0 Migration and invasion-inhibitory DUF4179 PF13786.6 CDI87963.1 - 1.9 9.0 7.9 0.95 10.0 6.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) DUF4569 PF15133.6 CDI87963.1 - 2 8.1 20.2 2.4 7.8 20.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) MRP-S31 PF15433.6 CDI87963.1 - 2.3 7.8 19.5 3.2 7.3 19.5 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 TMEM51 PF15345.6 CDI87963.1 - 2.4 7.9 21.1 0.95 9.3 2.6 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 Peptidase_M56 PF05569.11 CDI87963.1 - 2.4 7.3 6.4 2.9 7.0 6.4 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 Trp_oprn_chp PF09534.10 CDI87963.1 - 2.5 7.8 16.8 4.1 7.2 16.7 1.3 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Mucin PF01456.17 CDI87963.1 - 2.7 8.0 10.6 0.051 13.6 2.4 1.9 2 0 0 2 2 2 0 Mucin-like glycoprotein Serinc PF03348.15 CDI87963.1 - 2.7 6.8 9.4 3.5 6.5 9.4 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) FlaG PF03646.15 CDI87963.1 - 2.7 8.2 29.6 1.7 8.9 5.3 2.1 2 0 0 2 2 2 0 FlaG protein Ndc1_Nup PF09531.10 CDI87963.1 - 2.7 6.6 17.3 3.5 6.2 17.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SLC12 PF03522.15 CDI87963.1 - 2.7 6.9 17.6 3.8 6.4 17.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 CDI87963.1 - 3 7.8 12.9 3.9 7.4 12.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A EphA2_TM PF14575.6 CDI87963.1 - 3 8.8 16.4 2.2 9.2 4.0 2.3 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain 2HCT PF03390.15 CDI87963.1 - 3.6 6.1 4.6 4.6 5.8 4.6 1.2 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family PH_4 PF15404.6 CDI87963.1 - 3.7 7.3 16.8 4.6 7.0 6.9 2.0 1 1 1 2 2 2 0 Pleckstrin homology domain XRN_M PF17846.1 CDI87963.1 - 4.7 6.0 17.2 5.8 5.8 17.2 1.0 1 0 0 1 1 1 0 Xrn1 helical domain DUF2489 PF10675.9 CDI87963.1 - 5.4 6.9 28.0 7.9 6.4 7.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) NST1 PF13945.6 CDI87963.1 - 5.5 7.0 24.7 1.8 8.6 2.9 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator Sin_N PF04801.13 CDI87963.1 - 5.7 6.0 31.5 8.5 5.5 31.5 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region MDM10 PF12519.8 CDI87963.1 - 6.9 5.4 12.1 9.1 5.0 12.1 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF4647 PF15504.6 CDI87963.1 - 7.4 5.6 21.1 9 5.3 21.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) FAM150 PF15129.6 CDI87963.1 - 9.6 6.4 16.5 7.5 6.7 6.9 2.1 2 0 0 2 2 2 0 FAM150 family GET2 PF08690.10 CDI87964.1 - 0.0023 17.6 14.1 0.0031 17.3 14.1 1.2 1 0 0 1 1 1 1 GET complex subunit GET2 PAT1 PF09770.9 CDI87964.1 - 0.0047 15.3 21.7 0.0049 15.2 21.7 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 ANAPC_CDC26 PF10471.9 CDI87964.1 - 0.014 16.2 14.4 0.014 16.2 14.4 3.4 3 2 0 3 3 2 0 Anaphase-promoting complex APC subunit CDC26 DUF572 PF04502.13 CDI87964.1 - 0.022 14.4 7.1 0.027 14.1 7.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Chorion_2 PF03964.15 CDI87964.1 - 0.03 15.1 9.0 0.03 15.1 9.0 3.9 3 1 1 4 4 1 0 Chorion family 2 PIP5K PF01504.18 CDI87964.1 - 0.03 13.5 7.6 0.038 13.2 7.6 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase MRP-S31 PF15433.6 CDI87964.1 - 0.069 12.8 14.4 0.096 12.3 14.4 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 DUF2126 PF09899.9 CDI87964.1 - 0.071 11.2 5.1 0.088 10.9 5.1 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) GREB1 PF15782.5 CDI87964.1 - 0.28 8.2 14.4 0.4 7.7 14.4 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Calici_coat_C PF08435.11 CDI87964.1 - 0.38 10.2 8.5 0.6 9.6 8.5 1.3 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal DUF2828 PF11443.8 CDI87964.1 - 0.39 8.8 11.1 0.51 8.4 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Allexi_40kDa PF05549.11 CDI87964.1 - 0.55 9.7 10.5 0.82 9.1 10.5 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein Presenilin PF01080.17 CDI87964.1 - 0.65 8.7 18.6 0.93 8.2 18.6 1.2 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 CDI87964.1 - 0.72 7.7 13.3 0.88 7.4 13.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CaKB PF03185.15 CDI87964.1 - 0.76 9.4 6.7 1 9.0 6.7 1.1 1 0 0 1 1 1 0 Calcium-activated potassium channel, beta subunit SARAF PF06682.12 CDI87964.1 - 1 8.9 14.5 1.9 8.1 14.5 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3102 PF11300.8 CDI87964.1 - 1.2 9.4 13.2 0.92 9.8 1.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3102) Coilin_N PF15862.5 CDI87964.1 - 1.7 8.4 19.8 0.21 11.4 1.0 2.2 2 0 0 2 2 2 0 Coilin N-terminus CLN3 PF02487.17 CDI87964.1 - 2 7.4 8.7 2.8 6.9 8.7 1.2 1 0 0 1 1 1 0 CLN3 protein SLC12 PF03522.15 CDI87964.1 - 2 7.3 15.5 2.5 7.0 15.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF1764 PF08576.10 CDI87964.1 - 2.2 9.3 16.3 6.8 7.7 16.3 1.8 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Folliculin PF11704.8 CDI87964.1 - 2.6 7.9 11.1 5 7.0 11.1 1.5 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport RR_TM4-6 PF06459.12 CDI87964.1 - 2.7 7.7 13.2 4.2 7.1 13.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CCSAP PF15748.5 CDI87964.1 - 2.8 8.0 18.7 5.2 7.2 18.7 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated LMBR1 PF04791.16 CDI87964.1 - 3.2 6.6 4.2 3.6 6.4 4.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein CDT1_C PF16679.5 CDI87964.1 - 4.2 7.9 17.2 10 6.6 3.1 2.5 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain Suf PF05843.14 CDI87964.1 - 5.4 6.9 33.1 0.3 11.0 10.9 2.1 1 1 1 2 2 2 0 Suppressor of forked protein (Suf) Baculo_PP31 PF05311.11 CDI87964.1 - 6.5 6.2 11.5 10 5.5 11.5 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Membralin PF09746.9 CDI87964.1 - 6.7 5.6 6.7 8.7 5.3 6.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein UPF0565 PF10561.9 CDI87965.1 - 0.21 10.7 6.2 0.63 9.2 4.2 2.1 1 1 1 2 2 2 0 Uncharacterised protein family UPF0565 SID-1_RNA_chan PF13965.6 CDI87966.1 - 0.022 13.2 9.3 0.023 13.1 9.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RPOL_N PF14700.6 CDI87966.1 - 0.036 13.5 23.8 0.042 13.3 23.8 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal O-antigen_lig PF13425.6 CDI87966.1 - 0.11 11.3 8.1 0.11 11.3 8.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SARAF PF06682.12 CDI87966.1 - 0.14 11.8 18.7 0.15 11.7 18.7 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis CD20 PF04103.15 CDI87966.1 - 0.24 11.5 2.2 0.41 10.7 2.2 1.4 1 1 0 1 1 1 0 CD20-like family Bac_luciferase PF00296.20 CDI87966.1 - 0.35 10.3 12.3 0.44 9.9 12.3 1.1 1 0 0 1 1 1 0 Luciferase-like monooxygenase PIP5K PF01504.18 CDI87966.1 - 0.49 9.6 15.7 0.49 9.6 15.7 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase SelP_N PF04592.14 CDI87966.1 - 0.59 9.5 21.5 0.64 9.4 21.5 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Presenilin PF01080.17 CDI87966.1 - 0.66 8.7 31.9 0.75 8.5 31.9 1.0 1 0 0 1 1 1 0 Presenilin CobT PF06213.12 CDI87966.1 - 0.73 9.2 31.4 0.84 9.0 31.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Paf1 PF03985.13 CDI87966.1 - 0.79 8.7 23.6 0.81 8.6 23.6 1.1 1 0 0 1 1 1 0 Paf1 Ctr PF04145.15 CDI87966.1 - 0.84 10.3 11.6 1.1 9.9 11.6 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Serinc PF03348.15 CDI87966.1 - 0.85 8.5 16.3 1 8.2 16.3 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) BAF1_ABF1 PF04684.13 CDI87966.1 - 0.93 8.5 24.9 1.1 8.3 24.9 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Connexin PF00029.19 CDI87966.1 - 0.95 9.2 16.8 1.2 8.8 16.8 1.2 1 0 0 1 1 1 0 Connexin Velvet PF11754.8 CDI87966.1 - 0.97 9.3 24.0 1.2 9.1 24.0 1.1 1 0 0 1 1 1 0 Velvet factor MgsA_C PF12002.8 CDI87966.1 - 0.98 9.3 14.5 1.2 9.1 14.5 1.2 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal CDK5_activator PF03261.15 CDI87966.1 - 1 8.8 18.8 1.2 8.6 18.8 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein EOS1 PF12326.8 CDI87966.1 - 1.2 9.1 12.5 1.4 8.8 12.5 1.2 1 0 0 1 1 1 0 N-glycosylation protein DUF2052 PF09747.9 CDI87966.1 - 1.3 9.2 23.7 1.6 8.8 23.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SpoIIP PF07454.11 CDI87966.1 - 1.3 8.5 23.3 1.4 8.3 23.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Spc7_N PF15402.6 CDI87966.1 - 1.5 7.0 23.2 1.7 6.8 23.2 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Band_3_cyto PF07565.13 CDI87966.1 - 1.6 8.4 21.1 1.7 8.4 21.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain V_ATPase_I PF01496.19 CDI87966.1 - 2.5 5.9 23.3 2.4 6.0 23.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI87966.1 - 2.5 7.1 17.5 2.6 7.0 17.5 1.1 1 0 0 1 1 1 0 CLN3 protein Ureide_permease PF07168.11 CDI87966.1 - 2.9 6.6 9.3 3.3 6.3 9.3 1.2 1 0 0 1 1 1 0 Ureide permease Peptidase_S49_N PF08496.10 CDI87966.1 - 3 7.9 18.7 3.8 7.5 18.7 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal OATP PF03137.20 CDI87966.1 - 3 6.0 11.2 4.4 5.5 11.2 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Folate_carrier PF01770.18 CDI87966.1 - 3 6.5 10.9 3.8 6.2 10.9 1.2 1 0 0 1 1 1 0 Reduced folate carrier FAM60A PF15396.6 CDI87966.1 - 3 7.8 18.7 3.4 7.6 18.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A CSG2 PF16965.5 CDI87966.1 - 3.1 6.7 11.7 3.4 6.5 11.7 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator RR_TM4-6 PF06459.12 CDI87966.1 - 3.1 7.5 27.0 3.5 7.4 27.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.13 CDI87966.1 - 3.4 7.6 59.6 4.3 7.2 59.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Endostatin PF06482.11 CDI87966.1 - 3.4 7.0 23.8 3.5 7.0 23.8 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin eIF-3_zeta PF05091.12 CDI87966.1 - 3.5 6.5 30.1 3.7 6.4 30.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Neur_chan_memb PF02932.16 CDI87966.1 - 4.2 7.4 20.2 4.6 7.2 20.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2370 PF10176.9 CDI87966.1 - 4.2 6.9 13.1 4.8 6.8 13.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF4228 PF14009.6 CDI87966.1 - 4.5 7.6 15.2 5.4 7.4 15.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Pannexin_like PF12534.8 CDI87966.1 - 4.6 6.2 19.2 4.7 6.2 19.2 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 CDC45 PF02724.14 CDI87966.1 - 4.6 5.4 18.9 4.5 5.4 18.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.17 CDI87966.1 - 5.3 7.1 24.3 7 6.7 24.3 1.2 1 0 0 1 1 1 0 DDHD domain NPR3 PF03666.13 CDI87966.1 - 5.6 5.6 20.3 5.4 5.7 20.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Dynamin_N PF00350.23 CDI87966.1 - 5.6 7.0 13.3 9.4 6.3 13.3 1.4 1 0 0 1 1 1 0 Dynamin family ADP_ribosyl_GH PF03747.14 CDI87966.1 - 6.4 6.4 10.4 7 6.3 10.4 1.0 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase Peptidase_S15 PF02129.18 CDI87966.1 - 6.6 6.2 23.4 8.2 5.9 23.4 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) TCP PF03634.13 CDI87966.1 - 7.1 7.2 26.2 8.3 7.0 26.2 1.1 1 0 0 1 1 1 0 TCP family transcription factor Membralin PF09746.9 CDI87966.1 - 7.7 5.4 15.2 7.6 5.5 15.2 1.1 1 0 0 1 1 1 0 Tumour-associated protein Sec62 PF03839.16 CDI87966.1 - 8.3 5.9 18.9 8.7 5.8 18.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4446 PF14584.6 CDI87966.1 - 8.4 6.4 8.5 11 6.0 8.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) VIR_N PF15912.5 CDI87966.1 - 8.4 5.9 15.3 8.7 5.9 15.3 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Peptidase_U57 PF05582.12 CDI87966.1 - 9.1 5.5 15.6 9.7 5.4 15.6 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Rtf2 PF04641.12 CDI87966.1 - 9.8 5.5 22.0 12 5.1 22.0 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2433 PF10360.9 CDI87967.1 - 0.25 11.4 10.7 0.23 11.6 3.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2433) GAGA_bind PF06217.12 CDI87967.1 - 2.3 8.5 21.1 3.4 7.9 21.1 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family TFIIA PF03153.13 CDI87968.1 - 5.1 7.0 18.1 5.8 6.8 18.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Merozoite_SPAM PF07133.11 CDI87969.1 - 1.8 8.5 13.7 2.3 8.2 13.7 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Spore_coat_CotO PF14153.6 CDI87969.1 - 3.1 7.7 12.1 3.4 7.6 12.1 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Conotoxin PF02950.17 CDI87970.1 - 0.0014 19.6 4.5 0.0014 19.6 4.5 2.3 1 1 1 2 2 1 1 Conotoxin CDC45 PF02724.14 CDI87970.1 - 0.0014 17.0 6.1 0.0014 17.0 6.1 1.0 1 0 0 1 1 1 1 CDC45-like protein Suf PF05843.14 CDI87970.1 - 0.0024 17.9 23.6 0.0028 17.7 23.6 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Endostatin PF06482.11 CDI87970.1 - 0.012 15.1 17.6 0.014 14.9 17.6 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin FAM60A PF15396.6 CDI87970.1 - 0.012 15.6 11.9 0.016 15.2 11.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A RR_TM4-6 PF06459.12 CDI87970.1 - 0.014 15.3 15.1 0.016 15.0 15.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 CDI87970.1 - 0.016 14.5 5.3 0.018 14.2 5.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SARAF PF06682.12 CDI87970.1 - 0.029 14.1 13.2 0.034 13.8 13.2 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Ctr PF04145.15 CDI87970.1 - 0.036 14.7 14.5 0.18 12.4 14.5 1.8 1 1 0 1 1 1 0 Ctr copper transporter family DUF4569 PF15133.6 CDI87970.1 - 0.045 13.5 21.4 0.058 13.1 21.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) V_ATPase_I PF01496.19 CDI87970.1 - 0.053 11.5 17.0 0.063 11.2 17.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 CDI87970.1 - 0.055 12.2 20.1 0.063 12.0 20.1 1.2 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI87970.1 - 0.067 13.2 48.8 0.082 12.9 48.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PPP4R2 PF09184.11 CDI87970.1 - 0.08 12.5 7.4 0.089 12.4 7.4 1.1 1 0 0 1 1 1 0 PPP4R2 DUF4045 PF13254.6 CDI87970.1 - 0.086 12.5 13.1 0.095 12.3 13.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Neur_chan_memb PF02932.16 CDI87970.1 - 0.092 12.8 13.9 0.12 12.4 13.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region O-antigen_lig PF13425.6 CDI87970.1 - 0.098 11.4 9.5 0.12 11.2 9.5 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein NPR1_interact PF15699.5 CDI87970.1 - 0.11 13.1 12.5 0.2 12.3 12.5 1.4 1 0 0 1 1 1 0 NPR1 interacting Velvet PF11754.8 CDI87970.1 - 0.12 12.3 15.8 0.15 12.0 15.8 1.1 1 0 0 1 1 1 0 Velvet factor Gti1_Pac2 PF09729.9 CDI87970.1 - 0.15 12.2 11.1 0.27 11.3 11.1 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family ALMT PF11744.8 CDI87970.1 - 0.15 10.8 12.6 0.16 10.8 12.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Peroxin-3 PF04882.12 CDI87970.1 - 0.16 11.0 19.5 0.19 10.7 19.5 1.1 1 0 0 1 1 1 0 Peroxin-3 LAP1C PF05609.12 CDI87970.1 - 0.18 10.9 17.6 0.2 10.7 17.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) BAF1_ABF1 PF04684.13 CDI87970.1 - 0.21 10.6 15.8 0.24 10.4 15.8 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF2052 PF09747.9 CDI87970.1 - 0.23 11.6 15.1 0.29 11.2 15.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Hydin_ADK PF17213.3 CDI87970.1 - 0.25 11.6 19.4 0.34 11.2 19.4 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Dapper PF15268.6 CDI87970.1 - 0.27 10.1 25.4 0.3 9.9 25.4 1.0 1 0 0 1 1 1 0 Dapper Rit1_C PF17184.4 CDI87970.1 - 0.28 10.6 9.4 0.33 10.3 9.4 1.2 1 0 0 1 1 1 0 Rit1 N-terminal domain Paf1 PF03985.13 CDI87970.1 - 0.29 10.1 14.9 0.43 9.5 14.9 1.3 1 0 0 1 1 1 0 Paf1 Bul1_N PF04425.12 CDI87970.1 - 0.31 9.8 14.4 0.35 9.6 14.4 1.1 1 0 0 1 1 1 0 Bul1 N terminus PA26 PF04636.13 CDI87970.1 - 0.34 9.8 14.6 0.42 9.5 14.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Band_3_cyto PF07565.13 CDI87970.1 - 0.37 10.6 17.7 0.48 10.2 17.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain GPCR_chapero_1 PF11904.8 CDI87970.1 - 0.45 9.9 8.8 0.53 9.7 8.8 1.1 1 0 0 1 1 1 0 GPCR-chaperone GET2 PF08690.10 CDI87970.1 - 0.52 9.9 19.8 0.63 9.7 19.8 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Hid1 PF12722.7 CDI87970.1 - 0.56 8.3 17.6 0.63 8.1 17.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Dishevelled PF02377.15 CDI87970.1 - 0.56 10.6 10.4 0.82 10.1 10.4 1.1 1 0 0 1 1 1 0 Dishevelled specific domain Ndc1_Nup PF09531.10 CDI87970.1 - 0.6 8.7 16.0 0.79 8.3 16.0 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ABC2_membrane_2 PF12679.7 CDI87970.1 - 0.63 9.3 17.9 1.7 7.8 6.5 2.0 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF2828 PF11443.8 CDI87970.1 - 0.64 8.0 15.5 0.75 7.8 15.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MRP-S31 PF15433.6 CDI87970.1 - 0.67 9.6 21.0 0.77 9.4 21.0 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 DUF2126 PF09899.9 CDI87970.1 - 0.8 7.7 10.4 1.1 7.3 10.4 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) ETRAMP PF09716.10 CDI87970.1 - 0.81 9.8 3.9 5.6 7.1 3.9 2.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) SAGA-Tad1 PF12767.7 CDI87970.1 - 0.99 9.1 18.5 1.2 8.8 18.5 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit GREB1 PF15782.5 CDI87970.1 - 1.1 6.2 21.4 1.2 6.1 21.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Lin-8 PF03353.15 CDI87970.1 - 1.3 8.5 20.8 1.6 8.2 20.8 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF1180 PF06679.12 CDI87970.1 - 1.4 9.3 13.4 3.2 8.1 13.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) XRN_M PF17846.1 CDI87970.1 - 2.3 7.1 13.8 2.7 6.9 13.8 1.1 1 0 0 1 1 1 0 Xrn1 helical domain FAM176 PF14851.6 CDI87970.1 - 2.6 7.7 18.5 0.95 9.1 1.8 2.2 1 1 1 2 2 2 0 FAM176 family BORG_CEP PF14957.6 CDI87970.1 - 2.9 9.1 11.4 4.5 8.5 11.4 1.4 1 0 0 1 1 1 0 Cdc42 effector PAT1 PF09770.9 CDI87970.1 - 3.1 6.0 35.1 3.5 5.8 35.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3807 PF12720.7 CDI87970.1 - 3.1 8.0 28.9 5.3 7.3 28.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3807) DUF966 PF06136.13 CDI87970.1 - 3.6 7.2 15.4 4.3 7.0 15.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) OAD_gamma PF04277.13 CDI87970.1 - 4.2 8.0 9.4 1.3e+03 0.0 9.4 2.6 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF4064 PF13273.6 CDI87970.1 - 5.1 7.4 14.8 8.2e+03 -2.9 14.8 2.5 1 1 0 1 1 0 0 Protein of unknown function (DUF4064) Mucin PF01456.17 CDI87970.1 - 5.3 7.0 10.8 2.6 8.0 7.1 1.9 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF4400 PF14348.6 CDI87970.1 - 5.6 6.4 7.8 7.4 6.0 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) TRAP_alpha PF03896.16 CDI87970.1 - 6.6 5.9 12.1 18 4.4 12.1 1.7 1 1 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF3959 PF13105.6 CDI87970.1 - 7.5 6.0 14.4 8.5 5.8 14.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) DUF4956 PF16316.5 CDI87970.1 - 8.7 6.0 7.2 16 5.1 1.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4956) BPL_N PF09825.9 CDI87970.1 - 9.1 5.2 14.7 10 5.1 14.7 1.0 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Arv1 PF04161.13 CDI87970.1 - 9.2 6.4 16.9 3 7.9 3.9 2.1 1 1 1 2 2 2 0 Arv1-like family Spt20 PF12090.8 CDI87971.1 - 0.054 13.1 20.8 0.05 13.2 20.8 1.1 1 0 0 1 1 1 0 Spt20 family RskA PF10099.9 CDI87971.1 - 0.14 12.5 20.8 0.17 12.2 20.8 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF4179 PF13786.6 CDI87971.1 - 0.14 12.6 1.4 0.17 12.3 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) DUF3682 PF12446.8 CDI87971.1 - 0.18 12.3 14.7 0.24 11.9 14.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) DUF4834 PF16118.5 CDI87971.1 - 0.3 12.1 4.1 0.28 12.2 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TMEM208_SND2 PF05620.11 CDI87971.1 - 0.35 10.6 3.7 0.37 10.6 3.7 1.1 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DivIC PF04977.15 CDI87971.1 - 0.71 9.7 8.4 1 9.1 8.4 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF2722 PF10846.8 CDI87971.1 - 1.5 7.7 19.3 1.6 7.6 19.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Presenilin PF01080.17 CDI87971.1 - 2.2 6.9 4.3 2 7.1 4.3 1.1 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI87971.1 - 3.1 7.7 24.1 3.3 7.6 24.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI87971.1 - 4.1 7.3 11.4 4.4 7.2 11.4 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 CDI87972.1 - 0.23 10.2 12.1 0.28 9.9 12.1 1.1 1 0 0 1 1 1 0 Presenilin SR-25 PF10500.9 CDI87972.1 - 0.84 9.2 18.7 0.11 12.1 9.9 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein FAM176 PF14851.6 CDI87972.1 - 1.3 8.7 5.6 13 5.4 2.7 2.1 2 0 0 2 2 2 0 FAM176 family DUF4834 PF16118.5 CDI87972.1 - 4.4 8.3 19.6 5.5 8.0 2.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Conotoxin PF02950.17 CDI87972.1 - 4.7 8.3 10.1 9.8 7.3 4.8 2.3 2 0 0 2 2 2 0 Conotoxin CCDC24 PF15669.5 CDI87973.1 - 0.0072 16.2 3.8 0.013 15.4 3.8 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 24 family TFIIA PF03153.13 CDI87973.1 - 0.021 14.9 6.4 0.026 14.5 6.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CNDH2_N PF06278.11 CDI87973.1 - 0.041 14.1 0.2 0.073 13.3 0.2 1.4 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal AF-4 PF05110.13 CDI87973.1 - 0.046 11.8 12.7 0.05 11.7 12.7 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Spt20 PF12090.8 CDI87973.1 - 0.052 13.2 4.0 0.062 12.9 4.0 1.3 1 0 0 1 1 1 0 Spt20 family Sporozoite_P67 PF05642.11 CDI87973.1 - 0.085 10.9 3.2 0.099 10.7 3.2 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Lin-8 PF03353.15 CDI87973.1 - 0.11 12.0 3.0 0.14 11.7 3.0 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ribosomal_60s PF00428.19 CDI87973.1 - 0.19 12.3 11.9 0.071 13.7 7.1 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Roughex PF06020.11 CDI87973.1 - 0.59 9.2 3.2 0.82 8.7 3.2 1.2 1 0 0 1 1 1 0 Drosophila roughex protein CBFNT PF08143.11 CDI87973.1 - 6.1 8.3 17.6 17 6.9 8.5 2.3 2 0 0 2 2 2 0 CBFNT (NUC161) domain TFIIA PF03153.13 CDI87975.1 - 4.9e-05 23.5 41.2 7.5e-05 22.9 41.2 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CitMHS PF03600.16 CDI87975.1 - 0.054 12.7 9.9 0.064 12.4 9.9 1.1 1 0 0 1 1 1 0 Citrate transporter Stevor PF17410.2 CDI87975.1 - 0.11 12.0 5.0 0.15 11.6 5.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame NEMP PF10225.9 CDI87975.1 - 7.9 6.1 8.5 30 4.2 8.5 1.8 2 0 0 2 2 2 0 NEMP family PAP_central PF04928.17 CDI87976.1 - 0.0077 15.2 0.4 0.0086 15.1 0.4 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain BAF1_ABF1 PF04684.13 CDI87976.1 - 0.052 12.6 2.6 0.069 12.2 2.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF2722 PF10846.8 CDI87976.1 - 0.4 9.6 11.8 0.49 9.3 11.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI87976.1 - 0.89 9.5 13.4 1.2 9.1 13.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI87976.1 - 0.99 9.7 12.6 0.13 12.5 8.3 1.7 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Roughex PF06020.11 CDI87976.1 - 1.4 7.9 8.4 2 7.4 8.4 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Folliculin PF11704.8 CDI87976.1 - 2.1 8.2 7.0 4.1 7.2 7.0 1.4 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Presenilin PF01080.17 CDI87976.1 - 3.8 6.2 5.2 4.8 5.9 5.2 1.1 1 0 0 1 1 1 0 Presenilin Nop53 PF07767.11 CDI87976.1 - 3.9 6.8 17.4 5.5 6.3 17.4 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Spt20 PF12090.8 CDI87976.1 - 4.7 6.7 18.3 6.5 6.3 18.3 1.2 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 CDI87976.1 - 9.3 5.0 21.2 12 4.6 21.2 1.1 1 0 0 1 1 1 0 Androgen receptor FlaG PF03646.15 CDI87976.1 - 9.8 6.4 13.6 16 5.8 13.0 1.6 2 0 0 2 2 2 0 FlaG protein Macoilin PF09726.9 CDI87977.1 - 0.00031 19.5 43.2 0.00034 19.3 43.2 1.2 1 0 0 1 1 1 1 Macoilin family GREB1 PF15782.5 CDI87977.1 - 0.015 12.5 43.6 0.016 12.4 43.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RskA PF10099.9 CDI87977.1 - 0.42 10.9 33.1 5 7.4 18.9 3.9 1 1 0 2 2 2 0 Anti-sigma-K factor rskA Plasmodium_Vir PF05795.11 CDI87977.1 - 0.59 9.5 26.5 0.95 8.8 26.5 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DDRGK PF09756.9 CDI87977.1 - 0.85 9.2 37.4 1.4 8.5 37.4 1.3 1 0 0 1 1 1 0 DDRGK domain Utp14 PF04615.13 CDI87977.1 - 1.2 7.6 40.9 1.6 7.2 40.9 1.1 1 0 0 1 1 1 0 Utp14 protein Asp-B-Hydro_N PF05279.11 CDI87977.1 - 1.3 9.0 26.8 1.8 8.5 26.8 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Raftlin PF15250.6 CDI87977.1 - 5.6 5.6 33.7 8.3 5.0 33.7 1.3 1 0 0 1 1 1 0 Raftlin DUF3523 PF12037.8 CDI87977.1 - 9.6 5.5 42.5 14 4.9 42.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) Apt1 PF10351.9 CDI87978.1 - 0.52 9.1 3.4 0.55 9.0 3.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SR-25 PF10500.9 CDI87978.1 - 0.65 9.6 17.8 1 8.9 17.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 CDI87978.1 - 1.7 7.1 10.9 2.6 6.5 10.9 1.3 1 0 0 1 1 1 0 Macoilin family SOBP PF15279.6 CDI87978.1 - 6 7.4 23.5 7.6 7.0 23.5 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein ketoacyl-synt PF00109.26 CDI87979.1 - 0.0076 15.8 9.9 0.0095 15.5 9.9 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SR-25 PF10500.9 CDI87979.1 - 0.082 12.5 15.9 0.1 12.2 15.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Trp_oprn_chp PF09534.10 CDI87979.1 - 0.091 12.6 20.2 0.12 12.1 20.2 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) RskA PF10099.9 CDI87979.1 - 0.97 9.7 39.1 3.1 8.1 13.1 2.0 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Sacchrp_dh_NADP PF03435.18 CDI87979.1 - 3.1 8.1 10.8 3.7 7.8 10.8 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF4667 PF15700.5 CDI87979.1 - 4.2 7.4 20.5 5.5 7.0 20.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) Neur_chan_memb PF02932.16 CDI87979.1 - 8.7 6.3 12.3 12 5.9 12.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SAGA-Tad1 PF12767.7 CDI87979.1 - 9.4 5.9 18.1 10 5.8 18.1 1.0 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Cyclin_N PF00134.23 CDI87981.1 - 4.1e-09 36.2 0.4 9.1e-09 35.1 0.1 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CDI87981.1 - 0.00022 21.3 0.4 0.0041 17.2 0.0 2.6 2 1 1 3 3 3 1 Cyclin, C-terminal domain Spt20 PF12090.8 CDI87982.1 - 0.0031 17.1 2.2 0.0031 17.1 2.2 1.1 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI87982.1 - 0.0074 15.3 0.4 0.0076 15.2 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) eIF-3_zeta PF05091.12 CDI87983.1 - 1.4 7.8 26.7 1.7 7.6 26.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AAA_23 PF13476.6 CDI87983.1 - 2.2 8.7 23.5 2.9 8.4 23.5 1.1 1 0 0 1 1 1 0 AAA domain DUF2126 PF09899.9 CDI87983.1 - 2.4 6.1 10.6 1.9 6.4 10.6 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF4407 PF14362.6 CDI87983.1 - 3.9 6.7 22.4 4.2 6.6 22.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4834 PF16118.5 CDI87984.1 - 0.00013 22.8 5.2 0.00013 22.8 5.2 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4834) V_ATPase_I PF01496.19 CDI87984.1 - 0.0047 14.9 11.1 0.0076 14.2 11.1 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Connexin PF00029.19 CDI87984.1 - 0.013 15.3 3.6 0.02 14.6 3.6 1.3 1 0 0 1 1 1 0 Connexin FAM176 PF14851.6 CDI87984.1 - 0.015 14.9 1.6 0.028 14.1 1.6 1.4 1 0 0 1 1 1 0 FAM176 family Pex24p PF06398.11 CDI87984.1 - 0.019 14.0 0.2 0.029 13.4 0.2 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin EMC3_TMCO1 PF01956.16 CDI87984.1 - 0.036 13.8 4.0 0.047 13.4 4.0 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Spore_III_AF PF09581.10 CDI87984.1 - 0.037 14.1 6.2 0.062 13.3 6.2 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) eIF-3_zeta PF05091.12 CDI87984.1 - 0.041 12.9 12.4 0.047 12.7 12.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF5313 PF17240.2 CDI87984.1 - 0.1 13.1 0.4 0.28 11.6 0.4 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5313) Tmemb_9 PF05434.11 CDI87984.1 - 0.11 12.4 9.3 0.21 11.5 9.3 1.4 1 0 0 1 1 1 0 TMEM9 O-antigen_lig PF13425.6 CDI87984.1 - 0.12 11.2 0.5 0.16 10.7 0.5 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Sre PF03125.18 CDI87984.1 - 0.2 10.8 0.6 0.27 10.3 0.6 1.1 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor TRAP_alpha PF03896.16 CDI87984.1 - 0.24 10.6 7.0 0.056 12.6 3.6 1.6 1 1 1 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit PIP5K PF01504.18 CDI87984.1 - 0.28 10.3 8.2 0.5 9.5 8.2 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF4647 PF15504.6 CDI87984.1 - 0.38 9.8 16.6 0.51 9.4 16.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) TRC8_N PF13705.6 CDI87984.1 - 0.42 9.5 3.5 0.54 9.1 3.5 1.2 1 0 0 1 1 1 0 TRC8 N-terminal domain SID-1_RNA_chan PF13965.6 CDI87984.1 - 0.45 8.9 4.4 0.055 11.9 0.6 1.4 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 CDI87984.1 - 0.82 8.5 6.8 0.069 12.1 2.1 1.5 2 0 0 2 2 2 0 Ceramide synthase regulator Plasmodium_Vir PF05795.11 CDI87984.1 - 1.9 7.8 8.8 2.4 7.5 8.8 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF1980 PF09323.10 CDI87984.1 - 1.9 8.3 11.9 0.35 10.8 7.9 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) DUF4446 PF14584.6 CDI87984.1 - 2.1 8.3 7.1 3.4 7.7 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) NST1 PF13945.6 CDI87984.1 - 2.4 8.2 25.8 11 6.0 25.8 2.0 1 1 0 1 1 1 0 Salt tolerance down-regulator CRF1 PF10380.9 CDI87984.1 - 2.5 8.5 7.1 0.17 12.2 1.5 1.9 2 1 0 2 2 2 0 Transcription factor CRF1 PAP_RNA-bind PF04926.15 CDI87984.1 - 3.5 7.2 11.4 0.23 11.1 5.5 1.8 2 0 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain SOBP PF15279.6 CDI87984.1 - 3.6 8.1 20.3 5 7.7 20.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Hid1 PF12722.7 CDI87984.1 - 3.7 5.6 18.6 4.9 5.2 18.6 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Mitofilin PF09731.9 CDI87984.1 - 4.1 6.1 42.0 7 5.4 42.0 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein EOS1 PF12326.8 CDI87984.1 - 4.3 7.2 8.9 0.18 11.7 2.1 2.0 2 0 0 2 2 2 0 N-glycosylation protein RNA_pol_Rpc4 PF05132.14 CDI87985.1 - 0.0021 18.5 17.6 0.012 16.0 5.7 2.3 2 0 0 2 2 2 2 RNA polymerase III RPC4 Connexin PF00029.19 CDI87985.1 - 0.0045 16.8 14.4 0.12 12.1 7.8 2.2 2 0 0 2 2 2 2 Connexin Kei1 PF08552.11 CDI87985.1 - 0.0063 16.4 18.6 0.18 11.7 3.0 2.3 2 0 0 2 2 2 2 Inositolphosphorylceramide synthase subunit Kei1 Serinc PF03348.15 CDI87985.1 - 0.0067 15.4 2.9 0.0067 15.4 2.9 2.1 2 0 0 2 2 2 1 Serine incorporator (Serinc) DUF4366 PF14283.6 CDI87985.1 - 0.0076 16.3 10.1 0.13 12.3 3.8 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4366) BAF1_ABF1 PF04684.13 CDI87985.1 - 0.01 14.9 18.1 0.059 12.4 4.8 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Endostatin PF06482.11 CDI87985.1 - 0.016 14.7 21.0 0.018 14.5 9.9 2.2 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin FAM60A PF15396.6 CDI87985.1 - 0.034 14.2 19.7 0.29 11.1 9.3 2.2 2 0 0 2 2 2 0 Protein Family FAM60A SARAF PF06682.12 CDI87985.1 - 0.038 13.6 19.1 0.025 14.3 8.2 2.2 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis OATP PF03137.20 CDI87985.1 - 0.038 12.3 9.5 0.093 11.0 3.5 2.2 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Tim54 PF11711.8 CDI87985.1 - 0.043 12.6 22.5 0.012 14.4 9.3 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF2370 PF10176.9 CDI87985.1 - 0.045 13.4 8.8 0.075 12.7 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) ALMT PF11744.8 CDI87985.1 - 0.046 12.6 14.9 0.056 12.3 6.4 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter Zip PF02535.22 CDI87985.1 - 0.048 12.9 7.8 0.15 11.3 1.6 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter SRP-alpha_N PF04086.13 CDI87985.1 - 0.052 13.5 21.4 0.3 11.0 7.7 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal DUF2207 PF09972.9 CDI87985.1 - 0.096 11.4 1.7 3.4 6.3 0.1 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) SPX PF03105.19 CDI87985.1 - 0.13 12.2 19.1 0.2 11.6 19.0 1.4 1 1 0 1 1 1 0 SPX domain DUF4569 PF15133.6 CDI87985.1 - 0.18 11.5 29.3 1.3 8.7 17.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4569) CD20 PF04103.15 CDI87985.1 - 0.24 11.4 4.3 1.3 9.1 0.0 2.4 2 0 0 2 2 2 0 CD20-like family RR_TM4-6 PF06459.12 CDI87985.1 - 0.28 11.0 26.3 0.48 10.2 13.7 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 TYW3 PF02676.14 CDI87985.1 - 0.28 10.5 9.3 0.15 11.4 2.9 2.2 2 0 0 2 2 2 0 Methyltransferase TYW3 Peptidase_S64 PF08192.11 CDI87985.1 - 0.42 9.1 18.4 0.34 9.4 10.4 2.0 2 0 0 2 2 2 0 Peptidase family S64 EOS1 PF12326.8 CDI87985.1 - 0.42 10.5 16.6 2.1 8.2 2.9 2.4 2 0 0 2 2 2 0 N-glycosylation protein SUFU_C PF12470.8 CDI87985.1 - 0.73 9.9 15.2 2.4 8.2 8.7 2.3 2 0 0 2 2 2 0 Suppressor of Fused Gli/Ci N terminal binding domain Pet20 PF08692.10 CDI87985.1 - 0.92 10.2 11.8 0.69 10.6 3.8 2.6 2 0 0 2 2 2 0 Mitochondrial protein Pet20 Vac7 PF12751.7 CDI87985.1 - 1.1 8.6 18.8 2.9 7.2 18.8 1.6 1 1 0 1 1 1 0 Vacuolar segregation subunit 7 DAG_kinase_N PF14513.6 CDI87985.1 - 1.4 9.1 25.5 1.7 8.8 13.9 2.4 3 0 0 3 3 2 0 Diacylglycerol kinase N-terminus LMBR1 PF04791.16 CDI87985.1 - 1.4 7.7 15.1 1.8 7.4 15.1 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2126 PF09899.9 CDI87985.1 - 1.6 6.7 20.4 1.6 6.7 1.3 2.1 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) Ribosomal_60s PF00428.19 CDI87985.1 - 1.8 9.2 11.0 3.7 8.2 11.0 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Cellulose_synt PF03552.14 CDI87985.1 - 2 6.8 5.8 1.3 7.5 1.2 2.0 2 0 0 2 2 2 0 Cellulose synthase Rtf2 PF04641.12 CDI87985.1 - 2.9 7.2 25.6 1.2 8.4 11.0 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger Hydin_ADK PF17213.3 CDI87985.1 - 3.2 8.0 26.5 1 9.6 2.9 2.6 3 0 0 3 3 2 0 Hydin Adenylate kinase-like domain CCDC53 PF10152.9 CDI87985.1 - 3.2 8.1 36.9 0.83 10.1 17.5 2.5 3 0 0 3 3 2 0 Subunit CCDC53 of WASH complex CrgA PF06781.12 CDI87985.1 - 3.5 7.7 12.6 0.67 10.0 0.4 3.3 2 1 1 3 3 3 0 Cell division protein CrgA FixO PF02433.15 CDI87985.1 - 4.1 6.8 16.5 1.3 8.5 4.2 2.4 2 0 0 2 2 2 0 Cytochrome C oxidase, mono-heme subunit/FixO V_ATPase_I PF01496.19 CDI87985.1 - 4.3 5.1 29.7 0.37 8.7 15.9 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Afi1 PF07792.12 CDI87985.1 - 4.7 7.7 22.9 4.8 7.7 12.2 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DcuA_DcuB PF03605.14 CDI87985.1 - 4.8 6.0 10.9 6.5 5.5 4.0 2.4 2 1 1 3 3 3 0 Anaerobic c4-dicarboxylate membrane transporter Nucleoside_tran PF01733.18 CDI87985.1 - 5.2 6.4 7.8 4.5 6.6 3.0 2.1 2 0 0 2 2 2 0 Nucleoside transporter DUF3295 PF11702.8 CDI87985.1 - 5.4 6.3 29.1 0.011 15.1 8.7 2.3 3 0 0 3 3 2 0 Protein of unknown function (DUF3295) DUF2072 PF09845.9 CDI87985.1 - 5.4 7.3 19.0 4.1 7.7 8.5 2.3 2 0 0 2 2 2 0 Zn-ribbon containing protein 2OG-FeII_Oxy_5 PF13759.6 CDI87985.1 - 5.5 7.5 17.4 0.36 11.3 0.6 3.2 1 1 1 2 2 1 0 Putative 2OG-Fe(II) oxygenase NARP1 PF12569.8 CDI87985.1 - 6.8 5.5 28.6 3.7 6.3 15.6 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Trp_oprn_chp PF09534.10 CDI87985.1 - 7.8 6.3 18.2 0.16 11.7 4.0 3.2 2 1 1 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PTPRCAP PF15713.5 CDI87985.1 - 8.1 6.7 28.2 1.1 9.5 14.1 2.4 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated RPN2_C PF18004.1 CDI87985.1 - 8.3 6.3 26.3 1.8 8.5 11.0 2.3 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Med19 PF10278.9 CDI87985.1 - 8.7 6.2 14.6 0.63 9.9 3.7 2.3 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 BSMAP PF12280.8 CDI87985.1 - 9.5 6.4 32.0 0.1 12.8 13.8 2.3 2 1 1 3 3 2 0 Brain specific membrane anchored protein TCP PF03634.13 CDI87985.1 - 9.7 6.7 29.9 3.7 8.1 3.2 2.4 3 0 0 3 3 2 0 TCP family transcription factor Cnd2 PF05786.14 CDI87988.1 - 1.2 7.7 9.5 1.2 7.7 9.5 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 NPR3 PF03666.13 CDI87989.1 - 0.011 14.6 31.0 0.015 14.1 31.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 CDI87989.1 - 0.098 10.9 33.4 0.13 10.6 33.4 1.1 1 0 0 1 1 1 0 CDC45-like protein CRA PF06589.11 CDI87989.1 - 0.17 12.0 4.2 0.28 11.3 4.2 1.5 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) HCO3_cotransp PF00955.21 CDI87989.1 - 0.22 10.3 16.6 0.25 10.1 16.6 1.1 1 0 0 1 1 1 0 HCO3- transporter family SLC12 PF03522.15 CDI87989.1 - 0.29 10.1 41.9 0.39 9.7 41.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PA26 PF04636.13 CDI87989.1 - 0.83 8.5 28.0 1.1 8.1 28.0 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CAC1F_C PF16885.5 CDI87989.1 - 0.89 9.2 23.7 1.2 8.8 23.7 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term MDM10 PF12519.8 CDI87989.1 - 0.95 8.3 32.6 1.4 7.7 32.6 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SID-1_RNA_chan PF13965.6 CDI87989.1 - 1.2 7.5 24.0 1.6 7.1 24.0 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Hid1 PF12722.7 CDI87989.1 - 2.1 6.3 37.5 3 5.9 37.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CSG2 PF16965.5 CDI87989.1 - 4.9 6.0 25.4 4.1 6.3 24.1 1.6 1 1 0 1 1 1 0 Ceramide synthase regulator Mem_trans PF03547.18 CDI87989.1 - 5.2 5.4 15.6 5.9 5.2 15.6 1.2 1 0 0 1 1 1 0 Membrane transport protein KASH PF10541.9 CDI87989.1 - 5.3 7.4 8.5 4.7 7.6 0.7 2.3 2 0 0 2 2 2 0 Nuclear envelope localisation domain Raftlin PF15250.6 CDI87989.1 - 5.3 5.7 33.9 6.6 5.4 33.9 1.0 1 0 0 1 1 1 0 Raftlin Oxidored_q3 PF00499.20 CDI87989.1 - 5.4 6.7 5.8 1.5e+02 2.0 5.8 2.4 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF2151 PF10221.9 CDI87989.1 - 6.8 5.2 26.4 8.2 4.9 26.4 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator RCR PF12273.8 CDI87990.1 - 0.0027 18.3 0.0 0.0082 16.8 0.0 1.8 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red MCM_bind PF09739.9 CDI87991.1 - 2.3 6.6 38.1 2.6 6.4 38.1 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor LCD1 PF09798.9 CDI87992.1 - 0.00068 18.3 0.0 0.0011 17.6 0.0 1.3 1 1 0 1 1 1 1 DNA damage checkpoint protein Pex14_N PF04695.13 CDI87992.1 - 0.029 15.0 4.1 0.029 15.0 4.1 2.1 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF89 PF01937.19 CDI87992.1 - 0.06 12.3 0.6 0.089 11.7 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF89 DUF4179 PF13786.6 CDI87992.1 - 0.075 13.5 2.3 2.4 8.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) K_channel_TID PF07941.11 CDI87992.1 - 0.19 12.2 35.7 0.75 10.3 17.9 3.3 2 1 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain DUF4763 PF15960.5 CDI87992.1 - 0.71 9.1 21.0 0.84 8.9 4.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) Med15 PF09606.10 CDI87992.1 - 2.3 6.8 22.6 0.0049 15.6 11.5 1.9 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal OmpH PF03938.14 CDI87992.1 - 7.4 6.9 27.6 0.82 10.0 16.2 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) R_equi_Vir PF05526.11 CDI87992.1 - 7.7 6.3 9.7 5.3 6.9 3.8 2.1 2 0 0 2 2 2 0 Rhodococcus equi virulence-associated protein Connexin PF00029.19 CDI87993.1 - 0.26 11.0 19.8 0.3 10.8 19.8 1.0 1 0 0 1 1 1 0 Connexin MAP17 PF15807.5 CDI87993.1 - 0.36 11.1 14.5 0.38 11.0 14.5 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 FAM176 PF14851.6 CDI87993.1 - 0.6 9.8 13.2 0.74 9.5 13.2 1.2 1 0 0 1 1 1 0 FAM176 family TRAP_alpha PF03896.16 CDI87993.1 - 0.91 8.7 11.4 0.93 8.6 11.4 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RPN2_C PF18004.1 CDI87993.1 - 0.92 9.4 22.4 1 9.2 22.4 1.0 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CobT PF06213.12 CDI87993.1 - 1.2 8.5 31.0 1.2 8.5 31.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2370 PF10176.9 CDI87993.1 - 2.2 7.9 15.4 2.3 7.8 15.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Paf1 PF03985.13 CDI87993.1 - 2.6 7.0 24.7 2.7 6.9 24.7 1.0 1 0 0 1 1 1 0 Paf1 CLN3 PF02487.17 CDI87993.1 - 2.9 6.9 19.4 2.9 6.8 19.4 1.0 1 0 0 1 1 1 0 CLN3 protein Serinc PF03348.15 CDI87993.1 - 3.1 6.6 17.0 3.2 6.6 17.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) RNA_pol_Rpc4 PF05132.14 CDI87993.1 - 3.4 8.1 21.0 3.7 8.0 21.0 1.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 CCDC53 PF10152.9 CDI87993.1 - 3.4 8.1 23.2 3.4 8.1 23.2 1.0 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex V_ATPase_I PF01496.19 CDI87993.1 - 4 5.2 26.1 4.1 5.2 26.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PTPRCAP PF15713.5 CDI87993.1 - 4.7 7.5 26.4 5.2 7.3 26.4 1.0 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SpoIIP PF07454.11 CDI87993.1 - 5.9 6.3 26.8 6.4 6.1 26.8 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Kei1 PF08552.11 CDI87993.1 - 8.2 6.3 17.8 9.2 6.1 17.8 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 PIP5K PF01504.18 CDI87993.1 - 8.4 5.5 20.0 8.8 5.5 20.0 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase SID-1_RNA_chan PF13965.6 CDI87993.1 - 8.6 4.6 14.0 8.5 4.7 14.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF913 PF06025.12 CDI87993.1 - 9 5.2 17.7 9.2 5.1 17.7 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Baculo_PP31 PF05311.11 CDI87993.1 - 10 5.5 22.0 11 5.5 22.0 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) PPL5 PF18168.1 CDI87994.1 - 0.35 10.1 9.5 0.39 10.0 9.5 1.0 1 0 0 1 1 1 0 Prim-pol family 5 FYDLN_acid PF09538.10 CDI87994.1 - 1 10.1 11.2 1.1 10.0 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Connexin PF00029.19 CDI87994.1 - 2.4 7.9 13.8 2.6 7.8 13.8 1.0 1 0 0 1 1 1 0 Connexin DUF4834 PF16118.5 CDI87994.1 - 3 8.9 19.8 3.8 8.5 19.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3408 PF11888.8 CDI87994.1 - 3.6 7.7 19.1 3.6 7.7 19.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) V_ATPase_I PF01496.19 CDI87994.1 - 3.8 5.3 18.8 4.1 5.2 18.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Paf1 PF03985.13 CDI87994.1 - 4.2 6.2 21.7 4.1 6.3 21.7 1.0 1 0 0 1 1 1 0 Paf1 SpoIIP PF07454.11 CDI87994.1 - 4.4 6.7 20.9 4.4 6.7 20.9 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) AIF_C PF14721.6 CDI87994.1 - 4.5 7.6 13.7 4.7 7.6 13.7 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Gti1_Pac2 PF09729.9 CDI87994.1 - 5.1 7.2 13.7 5.4 7.1 13.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family CPSF100_C PF13299.6 CDI87994.1 - 5.8 7.1 15.4 5.6 7.1 15.4 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 CDI87994.1 - 6.7 6.4 18.7 6.5 6.5 18.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 EIIBC-GUT_N PF03612.14 CDI87994.1 - 6.8 6.4 16.9 6.7 6.4 16.9 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Orf78 PF06024.12 CDI87994.1 - 7.3 7.0 9.9 8.1 6.8 9.9 1.3 1 0 0 1 1 1 0 Orf78 (ac78) Presenilin PF01080.17 CDI87994.1 - 7.4 5.2 20.8 7.3 5.2 20.8 1.0 1 0 0 1 1 1 0 Presenilin DDHD PF02862.17 CDI87994.1 - 8.2 6.5 16.9 8.2 6.5 16.9 1.0 1 0 0 1 1 1 0 DDHD domain CobT PF06213.12 CDI87994.1 - 8.6 5.7 27.9 9.1 5.6 27.9 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3464 PF11947.8 CDI87994.1 - 8.9 6.1 18.4 8.7 6.1 18.4 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 FAM176 PF14851.6 CDI87994.1 - 9.8 5.8 13.6 11 5.7 13.6 1.1 1 0 0 1 1 1 0 FAM176 family Peptidase_C37 PF05416.12 CDI87995.1 - 0.078 11.5 5.4 0.088 11.3 5.4 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase Apt1 PF10351.9 CDI87995.1 - 0.32 9.8 20.4 0.3 9.9 20.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDI87995.1 - 0.39 9.2 31.7 0.47 8.9 31.7 1.1 1 0 0 1 1 1 0 Macoilin family HSD3 PF15244.6 CDI87995.1 - 0.43 10.0 23.5 0.47 9.9 23.5 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 MPM1 PF17234.2 CDI87995.1 - 2.1 8.6 13.9 3.7 7.8 13.9 1.5 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 TFIIA PF03153.13 CDI87995.1 - 3 7.7 39.2 3.8 7.4 39.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop25 PF09805.9 CDI87995.1 - 4.8 7.6 10.1 7.6 7.0 10.1 1.3 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) SLC12 PF03522.15 CDI87995.1 - 5.4 5.9 14.4 5.4 5.9 14.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 ECR1_N PF14382.6 CDI87996.1 - 6.5e-09 35.4 0.2 1.1e-08 34.8 0.2 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region DUF2722 PF10846.8 CDI87996.1 - 0.00057 19.0 11.6 0.0008 18.5 6.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) DUF5421 PF17458.2 CDI87996.1 - 0.0064 15.9 0.9 0.0064 15.9 0.9 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5421) Presenilin PF01080.17 CDI87996.1 - 0.016 14.0 0.3 0.022 13.5 0.3 1.2 1 0 0 1 1 1 0 Presenilin Senescence_reg PF04520.13 CDI87996.1 - 0.022 15.6 1.2 0.035 14.9 1.2 1.3 1 0 0 1 1 1 0 Senescence regulator DUF3464 PF11947.8 CDI87996.1 - 0.041 13.6 0.1 0.041 13.6 0.1 1.9 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 TERB2 PF15101.6 CDI87996.1 - 0.054 13.5 4.7 0.15 12.1 0.6 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 PH_10 PF15411.6 CDI87996.1 - 0.056 13.7 0.8 0.87 9.9 0.3 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain Dpy19 PF10034.9 CDI87996.1 - 0.071 11.3 0.0 0.091 10.9 0.0 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation EOS1 PF12326.8 CDI87996.1 - 0.084 12.8 0.1 0.11 12.4 0.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein SR-25 PF10500.9 CDI87996.1 - 0.1 12.2 12.8 2.3 7.8 8.7 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein PSII PF00421.19 CDI87996.1 - 0.12 11.0 0.0 0.17 10.5 0.0 1.2 1 0 0 1 1 1 0 Photosystem II protein ANAPC_CDC26 PF10471.9 CDI87996.1 - 0.18 12.7 21.4 1.5 9.7 0.9 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 DA1-like PF12315.8 CDI87996.1 - 0.22 10.9 6.1 1.6 8.1 0.1 2.2 2 0 0 2 2 2 0 Protein DA1 DUF4834 PF16118.5 CDI87996.1 - 0.62 11.1 9.7 0.12 13.3 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF775 PF05603.12 CDI87996.1 - 0.81 9.2 6.7 3 7.3 4.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF775) DUF3446 PF11928.8 CDI87996.1 - 1.2 9.5 9.4 9.7 6.6 4.9 2.2 2 0 0 2 2 2 0 Early growth response N-terminal domain Spt20 PF12090.8 CDI87996.1 - 1.4 8.4 25.2 0.11 12.1 15.7 2.1 2 0 0 2 2 2 0 Spt20 family DDHD PF02862.17 CDI87996.1 - 3 7.9 10.1 21 5.2 10.1 1.9 1 1 0 1 1 1 0 DDHD domain IMUP PF15761.5 CDI87996.1 - 6.5 7.5 15.4 1.1 9.9 6.5 2.1 2 0 0 2 2 2 0 Immortalisation up-regulated protein Pex14_N PF04695.13 CDI87996.1 - 9.2 6.9 16.2 1.5 9.4 8.1 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Memo PF01875.17 CDI87997.1 - 2.9e-50 170.9 0.0 3.4e-50 170.7 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Presenilin PF01080.17 CDI87998.1 - 0.79 8.4 43.0 0.84 8.3 43.0 1.0 1 0 0 1 1 1 0 Presenilin DUF4045 PF13254.6 CDI87998.1 - 3.4 7.2 31.0 3.8 7.1 31.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) MCM_bind PF09739.9 CDI87998.1 - 4.8 5.5 31.6 5.3 5.4 31.6 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor SLC12 PF03522.15 CDI87998.1 - 9.3 5.1 39.8 11 4.9 39.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CCSAP PF15748.5 CDI87998.1 - 9.5 6.3 42.2 12 6.0 42.2 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated TFIIA PF03153.13 CDI87999.1 - 0.61 10.0 34.8 0.7 9.8 34.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AF-4 PF05110.13 CDI87999.1 - 8.7 4.3 33.1 12 3.8 33.1 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein wnt PF00110.19 CDI88000.1 - 0.0036 16.9 0.2 0.0044 16.7 0.2 1.0 1 0 0 1 1 1 1 wnt family BAF1_ABF1 PF04684.13 CDI88000.1 - 0.0063 15.6 3.4 0.0075 15.4 3.4 1.0 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor IHABP4_N PF16174.5 CDI88000.1 - 0.51 10.9 10.5 0.32 11.6 8.7 1.5 1 1 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal STAC2_u1 PF16664.5 CDI88000.1 - 0.52 10.8 7.3 0.19 12.2 2.8 2.0 2 0 0 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 CCSAP PF15748.5 CDI88000.1 - 0.57 10.3 8.3 0.78 9.9 8.3 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated TFIIA PF03153.13 CDI88000.1 - 1.8 8.4 29.5 2.3 8.1 29.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI88000.1 - 2.2 8.5 25.7 0.75 10.1 17.9 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Med15 PF09606.10 CDI88000.1 - 2.2 6.9 29.8 2.8 6.5 29.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PTPRCAP PF15713.5 CDI88001.1 - 0.01 16.1 5.4 0.011 16.0 5.4 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Presenilin PF01080.17 CDI88001.1 - 1.6 7.4 5.0 1.8 7.3 5.0 1.1 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CDI88001.1 - 2.7 9.0 12.4 0.071 14.1 3.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) V_ATPase_I PF01496.19 CDI88001.1 - 4.5 5.1 10.1 4.5 5.0 10.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TFIIA PF03153.13 CDI88003.1 - 0.095 12.7 47.1 0.11 12.5 47.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4175 PF13779.6 CDI88003.1 - 0.12 10.2 34.0 0.12 10.3 34.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) NST1 PF13945.6 CDI88003.1 - 0.16 12.0 36.4 0.19 11.8 36.4 1.0 1 0 0 1 1 1 0 Salt tolerance down-regulator PI3K_1B_p101 PF10486.9 CDI88003.1 - 0.69 7.6 19.9 0.77 7.5 19.9 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Cwf_Cwc_15 PF04889.12 CDI88003.1 - 0.77 9.4 27.0 0.98 9.1 27.0 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3439 PF11921.8 CDI88003.1 - 1.1 9.3 6.1 1.5 8.8 6.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3439) AF-4 PF05110.13 CDI88003.1 - 1.1 7.2 31.9 1.3 7.1 31.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Macoilin PF09726.9 CDI88003.1 - 1.2 7.6 31.3 1.3 7.4 31.3 1.0 1 0 0 1 1 1 0 Macoilin family UPF0524 PF15823.5 CDI88003.1 - 1.2 8.5 16.4 1.7 8.0 16.4 1.3 1 0 0 1 1 1 0 UPF0524 of C3orf70 FAM76 PF16046.5 CDI88003.1 - 1.4 8.2 24.4 1.6 8.0 24.4 1.1 1 0 0 1 1 1 0 FAM76 protein SSP160 PF06933.11 CDI88003.1 - 1.6 6.8 17.6 1.9 6.6 17.6 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 MMR1 PF08505.10 CDI88003.1 - 1.8 8.8 34.7 2.1 8.5 34.7 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Nop25 PF09805.9 CDI88003.1 - 2.6 8.5 27.6 3 8.3 27.6 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Bud13 PF09736.9 CDI88003.1 - 2.8 8.3 26.5 3 8.2 26.5 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex CNDH2_C PF16858.5 CDI88003.1 - 3.7 7.3 26.4 4.2 7.1 26.4 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term BAT2_N PF07001.11 CDI88003.1 - 4 7.9 34.5 5.3 7.5 34.5 1.2 1 0 0 1 1 1 0 BAT2 N-terminus Plasmodium_Vir PF05795.11 CDI88003.1 - 6.7 6.0 25.3 7.6 5.8 25.3 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SLC12 PF03522.15 CDI88003.1 - 7.2 5.5 31.0 7.9 5.4 31.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PepSY_TM PF03929.16 CDI88003.1 - 7.4 6.2 13.3 8.5 6.0 13.3 1.1 1 0 0 1 1 1 0 PepSY-associated TM region SRP-alpha_N PF04086.13 CDI88003.1 - 7.9 6.3 29.1 8.9 6.1 29.1 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Totivirus_coat PF05518.11 CDI88003.1 - 8.2 4.3 13.4 9.7 4.1 13.4 1.0 1 0 0 1 1 1 0 Totivirus coat protein DUF4638 PF15472.6 CDI88003.1 - 9.7 5.8 18.7 13 5.4 18.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) PE_PPE_C PF12484.8 CDI88004.1 - 8.8 7.3 36.1 4.5 8.2 6.8 3.4 3 0 0 3 3 3 0 Polymorphic PE/PPE proteins C terminal TFIIA PF03153.13 CDI88006.1 - 0.0039 17.3 15.2 0.0046 17.0 15.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI88006.1 - 0.0057 17.0 12.7 0.0097 16.2 12.7 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA AMP-binding PF00501.28 CDI88006.1 - 0.006 15.2 0.9 0.0067 15.1 0.9 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Spt20 PF12090.8 CDI88006.1 - 0.016 14.8 10.9 0.016 14.8 10.9 1.4 2 0 0 2 2 2 0 Spt20 family RAB3GAP2_N PF14655.6 CDI88006.1 - 0.055 12.7 1.4 0.088 12.1 1.4 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF2362 PF10154.9 CDI88006.1 - 0.35 9.8 9.7 0.46 9.4 9.7 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) POX PF07526.11 CDI88006.1 - 0.54 10.8 7.4 5.6 7.5 3.0 2.3 2 0 0 2 2 2 0 Associated with HOX DUF2722 PF10846.8 CDI88006.1 - 1.4 7.8 16.7 0.28 10.1 13.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) PDDEXK_6 PF04720.12 CDI88006.1 - 5 7.0 13.2 2.8 7.8 5.1 2.2 2 0 0 2 2 2 0 PDDEXK-like family of unknown function DUF4834 PF16118.5 CDI88006.1 - 8.6 7.4 11.7 1.2 10.1 5.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Trp_oprn_chp PF09534.10 CDI88007.1 - 0.002 18.0 3.9 0.0025 17.6 3.9 1.2 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4820 PF16091.5 CDI88007.1 - 0.0083 15.5 7.1 0.0094 15.3 7.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4820) Shadoo PF14999.6 CDI88007.1 - 0.012 15.7 1.0 0.013 15.6 1.0 1.1 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective FHIPEP PF00771.20 CDI88007.1 - 0.019 13.4 8.1 0.02 13.4 8.1 1.0 1 0 0 1 1 1 0 FHIPEP family DUF3824 PF12868.7 CDI88007.1 - 0.02 15.5 11.6 0.026 15.2 11.6 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) DcuA_DcuB PF03605.14 CDI88007.1 - 0.037 12.9 4.8 0.046 12.6 4.8 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter CD20 PF04103.15 CDI88007.1 - 0.04 14.0 1.7 0.056 13.5 1.7 1.4 1 1 0 1 1 1 0 CD20-like family MecA PF05389.12 CDI88007.1 - 0.046 13.3 8.1 0.047 13.3 8.1 1.0 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF4228 PF14009.6 CDI88007.1 - 0.075 13.4 5.9 0.08 13.3 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) SID-1_RNA_chan PF13965.6 CDI88007.1 - 0.079 11.4 4.7 0.078 11.4 4.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TRAP_alpha PF03896.16 CDI88007.1 - 0.082 12.1 5.8 0.083 12.1 5.8 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Coilin_N PF15862.5 CDI88007.1 - 0.083 12.7 11.4 0.096 12.5 11.4 1.3 1 0 0 1 1 1 0 Coilin N-terminus DUF1980 PF09323.10 CDI88007.1 - 0.12 12.2 8.1 0.13 12.1 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF4956 PF16316.5 CDI88007.1 - 0.13 11.9 0.7 0.14 11.8 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4956) Zip PF02535.22 CDI88007.1 - 0.13 11.4 3.7 0.16 11.2 3.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CLN3 PF02487.17 CDI88007.1 - 0.13 11.2 7.2 0.14 11.2 7.2 1.0 1 0 0 1 1 1 0 CLN3 protein FPN1 PF06963.12 CDI88007.1 - 0.14 10.7 5.0 0.15 10.6 5.0 1.0 1 0 0 1 1 1 0 Ferroportin1 (FPN1) R_equi_Vir PF05526.11 CDI88007.1 - 0.15 11.9 12.3 0.16 11.8 12.3 1.0 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF4179 PF13786.6 CDI88007.1 - 0.15 12.5 2.8 0.21 12.1 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) DUF4446 PF14584.6 CDI88007.1 - 0.16 12.0 5.1 0.17 11.8 5.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) V_ATPase_I PF01496.19 CDI88007.1 - 0.17 9.8 11.6 0.17 9.8 11.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AIF_C PF14721.6 CDI88007.1 - 0.19 12.1 10.8 0.22 11.9 10.8 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Folate_carrier PF01770.18 CDI88007.1 - 0.23 10.2 5.4 0.25 10.0 5.4 1.2 1 0 0 1 1 1 0 Reduced folate carrier Peptidase_S49_N PF08496.10 CDI88007.1 - 0.29 11.2 10.2 0.36 10.9 10.2 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal HA2 PF04408.23 CDI88007.1 - 0.35 11.2 8.9 0.41 10.9 8.9 1.1 1 0 0 1 1 1 0 Helicase associated domain (HA2) Presenilin PF01080.17 CDI88007.1 - 0.53 9.0 16.0 0.57 8.9 16.0 1.1 1 0 0 1 1 1 0 Presenilin DUF4259 PF14078.6 CDI88007.1 - 0.54 11.0 9.1 0.59 10.9 9.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4259) Serinc PF03348.15 CDI88007.1 - 0.55 9.1 10.7 0.6 9.0 10.7 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) SpoIIP PF07454.11 CDI88007.1 - 0.55 9.6 14.4 0.55 9.6 14.4 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) eIF-3_zeta PF05091.12 CDI88007.1 - 0.59 9.0 17.8 0.59 9.1 17.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) OATP PF03137.20 CDI88007.1 - 0.6 8.3 6.3 0.61 8.3 6.3 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family BAF1_ABF1 PF04684.13 CDI88007.1 - 0.64 9.0 16.9 0.66 9.0 16.9 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor UPF0239 PF06783.11 CDI88007.1 - 0.69 10.1 10.4 0.93 9.7 10.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) 2HCT PF03390.15 CDI88007.1 - 0.73 8.4 4.8 0.78 8.3 4.8 1.0 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family CSG2 PF16965.5 CDI88007.1 - 0.92 8.4 6.5 0.9 8.4 6.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator EIIBC-GUT_N PF03612.14 CDI88007.1 - 0.99 9.1 11.5 1.1 8.9 11.5 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Gastrin PF00918.17 CDI88007.1 - 1 10.4 13.7 1.1 10.2 13.7 1.0 1 0 0 1 1 1 0 Gastrin/cholecystokinin family HemX PF04375.14 CDI88007.1 - 1.1 8.4 30.7 1.3 8.3 30.7 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase THOC2_N PF16134.5 CDI88007.1 - 1.2 7.7 14.2 1.3 7.6 14.2 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus O-antigen_lig PF13425.6 CDI88007.1 - 1.3 7.7 6.0 1.5 7.5 6.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CPSF100_C PF13299.6 CDI88007.1 - 1.5 9.0 12.5 1.6 8.9 12.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal PigN PF04987.14 CDI88007.1 - 1.5 7.6 5.1 1.5 7.6 5.1 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Ureide_permease PF07168.11 CDI88007.1 - 1.6 7.4 7.4 1.7 7.3 7.4 1.1 1 0 0 1 1 1 0 Ureide permease Spt20 PF12090.8 CDI88007.1 - 1.7 8.2 39.2 1.9 8.0 39.2 1.2 1 0 0 1 1 1 0 Spt20 family EOS1 PF12326.8 CDI88007.1 - 1.9 8.4 7.3 2 8.3 7.3 1.1 1 0 0 1 1 1 0 N-glycosylation protein DDHD PF02862.17 CDI88007.1 - 1.9 8.6 14.0 2 8.6 14.0 1.0 1 0 0 1 1 1 0 DDHD domain DUF3537 PF12056.8 CDI88007.1 - 2.2 7.0 11.1 2.5 6.9 11.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) CBP_BcsG PF11658.8 CDI88007.1 - 2.3 6.5 13.7 2.4 6.5 13.7 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG PPL5 PF18168.1 CDI88007.1 - 3.2 7.0 11.6 3.4 6.9 11.6 1.0 1 0 0 1 1 1 0 Prim-pol family 5 DUF2232 PF09991.9 CDI88007.1 - 3.4 6.8 9.6 3.7 6.7 9.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) TFB6 PF17110.5 CDI88007.1 - 3.7 7.3 9.7 3.9 7.2 9.7 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH TFIIA PF03153.13 CDI88007.1 - 4.1 7.3 40.0 4.5 7.2 40.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TMEM208_SND2 PF05620.11 CDI88007.1 - 4.3 7.1 14.1 7.1 6.4 14.1 1.4 1 1 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 TERB2 PF15101.6 CDI88007.1 - 4.5 7.3 20.2 4.8 7.2 20.2 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 NEMP PF10225.9 CDI88007.1 - 5.2 6.7 6.8 5.4 6.6 6.8 1.1 1 0 0 1 1 1 0 NEMP family UPF0560 PF10577.9 CDI88007.1 - 5.3 5.4 21.1 4.8 5.6 21.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Ctr PF04145.15 CDI88007.1 - 5.9 7.5 11.1 8 7.1 11.1 1.3 1 1 0 1 1 1 0 Ctr copper transporter family Kei1 PF08552.11 CDI88007.1 - 6.1 6.7 13.5 6.7 6.5 13.5 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Spore_coat_CotO PF14153.6 CDI88007.1 - 6.2 6.7 22.9 6.8 6.6 22.9 1.0 1 0 0 1 1 1 0 Spore coat protein CotO RR_TM4-6 PF06459.12 CDI88007.1 - 6.6 6.5 15.2 6.8 6.4 15.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI88007.1 - 7.2 4.7 25.6 7.5 4.7 25.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FAM60A PF15396.6 CDI88007.1 - 9.1 6.2 12.0 9.6 6.1 12.0 1.0 1 0 0 1 1 1 0 Protein Family FAM60A RskA PF10099.9 CDI88007.1 - 9.9 6.4 29.9 20 5.4 29.9 1.5 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF755 PF05501.11 CDI88008.1 - 0.0042 17.4 31.2 0.0042 17.4 31.2 2.7 2 1 1 3 3 2 1 Domain of unknown function (DUF755) DUF4718 PF15842.5 CDI88008.1 - 0.0054 16.5 15.4 0.0054 16.5 15.4 2.3 1 1 1 2 2 1 1 Domain of unknown function (DUF4718) PIG-U PF06728.13 CDI88008.1 - 0.026 13.6 1.5 0.03 13.4 1.5 1.1 1 0 0 1 1 1 0 GPI transamidase subunit PIG-U BBS2_N PF14781.6 CDI88008.1 - 0.21 11.5 9.6 0.85 9.6 1.8 3.1 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal Cwf_Cwc_15 PF04889.12 CDI88008.1 - 0.21 11.3 11.7 0.23 11.2 5.4 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Peptidase_S49_N PF08496.10 CDI88008.1 - 0.37 10.8 10.0 2.9 8.0 4.5 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal UPF0542 PF15086.6 CDI88008.1 - 0.48 10.4 5.3 2.5 8.1 0.5 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 Macoilin PF09726.9 CDI88008.1 - 0.62 8.6 23.1 0.81 8.2 23.1 1.2 1 0 0 1 1 1 0 Macoilin family Spore_YhcN_YlaJ PF09580.10 CDI88008.1 - 0.64 10.1 7.8 5.6 7.0 3.1 2.1 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FKBP_N PF01346.18 CDI88008.1 - 0.85 10.6 15.0 1.4 9.9 0.5 2.3 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase DDE_Tnp_1_2 PF13586.6 CDI88008.1 - 1.7 9.1 6.6 20 5.7 1.6 2.5 2 0 0 2 2 2 0 Transposase DDE domain MPM1 PF17234.2 CDI88008.1 - 2.1 8.6 21.0 0.56 10.4 8.2 2.3 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Histone_HNS PF00816.21 CDI88008.1 - 2.3 9.1 12.6 0.57 11.0 1.1 2.3 2 0 0 2 2 2 0 H-NS histone family DUF2489 PF10675.9 CDI88008.1 - 2.9 7.8 27.9 1.1 9.2 5.8 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2489) Rpp20 PF12328.8 CDI88008.1 - 3 7.8 13.5 2.2 8.3 4.1 2.5 3 0 0 3 3 3 0 Rpp20 subunit of nuclear RNase MRP and P SLC12 PF03522.15 CDI88008.1 - 3.1 6.7 19.5 4.1 6.3 19.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI88008.1 - 4 5.5 22.1 5.1 5.1 22.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2721 PF11026.8 CDI88008.1 - 4.6 7.1 5.9 1.3 8.9 1.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Cas1_AcylT PF07779.12 CDI88008.1 - 4.6 6.0 13.9 1 8.2 6.8 2.0 2 0 0 2 2 2 0 10 TM Acyl Transferase domain found in Cas1p CemA PF03040.14 CDI88008.1 - 5.1 7.0 6.7 13 5.7 2.2 2.1 2 0 0 2 2 2 0 CemA family RED_N PF07808.13 CDI88008.1 - 5.8 6.4 13.8 1.4 8.4 3.5 2.3 2 0 0 2 2 2 0 RED-like protein N-terminal region Peptidase_S64 PF08192.11 CDI88008.1 - 6.9 5.0 25.3 8.1 4.8 25.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 PilM PF07419.12 CDI88008.1 - 7.8 6.7 11.9 0.63 10.2 2.0 2.4 2 0 0 2 2 2 0 PilM SPX PF03105.19 CDI88008.1 - 9.1 6.1 21.4 14 5.5 21.4 1.2 1 0 0 1 1 1 0 SPX domain TMEM164 PF14808.6 CDI88008.1 - 9.5 5.5 6.7 6.9 5.9 0.7 2.1 2 0 0 2 2 2 0 TMEM164 family CDC45 PF02724.14 CDI88009.1 - 0.17 10.1 21.0 0.17 10.2 21.0 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI88009.1 - 1.1 8.3 25.6 1 8.3 25.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 NPR3 PF03666.13 CDI88009.1 - 1.4 7.6 20.7 1.5 7.5 20.7 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TFIIF_alpha PF05793.12 CDI88009.1 - 1.6 7.2 20.4 1.8 7.1 20.4 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) V_ATPase_I PF01496.19 CDI88009.1 - 2.3 6.0 22.3 2.6 5.8 22.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Lin-8 PF03353.15 CDI88009.1 - 2.6 7.5 34.8 2.9 7.4 34.8 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF572 PF04502.13 CDI88009.1 - 2.9 7.4 31.2 3.7 7.1 31.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) SDA1 PF05285.12 CDI88009.1 - 3.7 6.9 27.1 5 6.4 27.1 1.3 1 0 0 1 1 1 0 SDA1 ALMT PF11744.8 CDI88009.1 - 3.9 6.2 19.3 4.4 6.0 19.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4719 PF15843.5 CDI88010.1 - 2.2 8.4 4.9 2.6 8.1 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) SR-25 PF10500.9 CDI88011.1 - 3.7e-07 30.0 29.4 4.2e-07 29.8 29.4 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF3474 PF11960.8 CDI88011.1 - 0.0095 16.1 5.5 0.014 15.6 5.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) PI3K_1B_p101 PF10486.9 CDI88011.1 - 0.03 12.1 19.5 0.032 12.0 19.5 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CCDC106 PF15794.5 CDI88011.1 - 0.08 12.6 23.8 0.095 12.4 23.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 IMUP PF15761.5 CDI88011.1 - 1.1 10.0 20.8 1.6 9.5 20.8 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein Suf PF05843.14 CDI88011.1 - 1.5 8.7 31.2 1.7 8.6 31.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SMYLE_N PF18615.1 CDI88011.1 - 1.8 8.0 23.3 2 7.9 23.3 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain TCP PF03634.13 CDI88011.1 - 2 9.0 27.6 2.5 8.6 27.6 1.2 1 0 0 1 1 1 0 TCP family transcription factor ASD2 PF08687.11 CDI88011.1 - 2.7 7.5 27.5 2.9 7.4 27.5 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 CDC45 PF02724.14 CDI88011.1 - 3.6 5.8 25.3 3.7 5.7 25.3 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF5523 PF17661.1 CDI88011.1 - 4.3 6.9 21.5 5.8 6.5 21.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Nop14 PF04147.12 CDI88011.1 - 4.6 5.3 22.8 4.9 5.2 22.8 1.0 1 0 0 1 1 1 0 Nop14-like family NPR3 PF03666.13 CDI88011.1 - 5.4 5.7 28.6 5.5 5.7 28.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CAC1F_C PF16885.5 CDI88011.1 - 5.7 6.5 20.0 6.3 6.4 20.0 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term DUF4614 PF15391.6 CDI88011.1 - 5.8 6.9 32.3 6.6 6.7 32.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) YL1 PF05764.13 CDI88011.1 - 6 6.9 33.2 7.4 6.6 33.2 1.1 1 0 0 1 1 1 0 YL1 nuclear protein MFMR_assoc PF16596.5 CDI88011.1 - 7.2 7.1 24.4 7.9 6.9 24.4 1.1 1 0 0 1 1 1 0 Disordered region downstream of MFMR TFIIA PF03153.13 CDI88011.1 - 7.5 6.4 52.3 8.5 6.3 52.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Dsh_C PF12316.8 CDI88011.1 - 8.1 6.8 25.4 12 6.2 25.4 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal TraH PF06122.11 CDI88011.1 - 8.7 5.5 21.1 9.2 5.4 21.1 1.0 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein BAF1_ABF1 PF04684.13 CDI88011.1 - 8.7 5.3 28.5 9.6 5.1 28.5 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Ureide_permease PF07168.11 CDI88011.1 - 9.6 4.8 9.4 10 4.7 9.4 1.2 1 0 0 1 1 1 0 Ureide permease PA26 PF04636.13 CDI88011.1 - 9.8 5.0 22.2 11 4.9 22.2 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Adeno_PV PF03910.13 CDI88012.1 - 0.15 10.7 10.8 0.21 10.3 10.8 1.2 1 0 0 1 1 1 0 Adenovirus minor core protein PV CDC45 PF02724.14 CDI88012.1 - 0.92 7.7 23.9 0.95 7.7 23.9 1.2 1 0 0 1 1 1 0 CDC45-like protein SelP_N PF04592.14 CDI88012.1 - 1.2 8.5 29.8 1.7 8.0 29.8 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region V_ATPase_I PF01496.19 CDI88012.1 - 1.9 6.3 29.5 2.3 6.1 29.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family VIR_N PF15912.5 CDI88012.1 - 2.3 7.7 15.7 2.9 7.4 15.7 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal TFIIA PF03153.13 CDI88012.1 - 2.8 7.8 80.9 4.4 7.2 80.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RIFIN PF02009.16 CDI88012.1 - 3.8 7.3 28.8 4.3 7.1 28.8 1.1 1 0 0 1 1 1 0 Rifin Hamartin PF04388.12 CDI88012.1 - 9.4 4.8 32.5 12 4.4 32.5 1.2 1 0 0 1 1 1 0 Hamartin protein DUF4252 PF14060.6 CDI88013.1 - 0.32 10.9 9.3 0.41 10.5 9.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) Presenilin PF01080.17 CDI88013.1 - 9.8 4.8 26.4 11 4.6 26.4 1.1 1 0 0 1 1 1 0 Presenilin CCSAP PF15748.5 CDI88014.1 - 0.041 14.0 46.9 0.054 13.7 46.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated XRN_M PF17846.1 CDI88014.1 - 0.046 12.7 30.0 0.06 12.3 30.0 1.3 1 0 0 1 1 1 0 Xrn1 helical domain SOBP PF15279.6 CDI88014.1 - 0.077 13.6 36.9 0.087 13.4 36.9 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein PAT1 PF09770.9 CDI88014.1 - 0.12 10.6 58.2 0.14 10.4 58.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1387 PF07139.11 CDI88014.1 - 0.2 11.4 39.5 0.26 11.0 39.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) CDC45 PF02724.14 CDI88014.1 - 0.2 9.9 36.2 0.25 9.6 36.2 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 CDI88014.1 - 0.25 10.7 39.9 0.32 10.4 39.9 1.1 1 0 0 1 1 1 0 SDA1 GAGA_bind PF06217.12 CDI88014.1 - 0.47 10.7 33.2 0.54 10.5 33.2 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4045 PF13254.6 CDI88014.1 - 0.82 9.2 37.9 1 8.9 37.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) GREB1 PF15782.5 CDI88014.1 - 0.82 6.7 43.8 0.93 6.5 43.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ten_N PF06484.12 CDI88014.1 - 0.83 9.5 23.3 0.94 9.3 23.3 1.1 1 0 0 1 1 1 0 Teneurin Intracellular Region Raftlin PF15250.6 CDI88014.1 - 1.2 7.8 33.8 1.5 7.5 33.8 1.1 1 0 0 1 1 1 0 Raftlin SLC12 PF03522.15 CDI88014.1 - 1.4 7.9 44.1 2 7.3 44.1 1.4 1 0 0 1 1 1 0 Solute carrier family 12 WTX PF09422.10 CDI88014.1 - 1.7 7.6 30.6 2.1 7.3 30.6 1.1 1 0 0 1 1 1 0 WTX protein Dapper PF15268.6 CDI88014.1 - 2 7.2 44.6 2.3 7.0 44.6 1.1 1 0 0 1 1 1 0 Dapper ALMT PF11744.8 CDI88014.1 - 3.3 6.4 35.5 4.1 6.1 35.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter MTBP_C PF14920.6 CDI88014.1 - 3.4 7.4 32.9 4.6 6.9 32.9 1.3 1 0 0 1 1 1 0 MDM2-binding Hamartin PF04388.12 CDI88014.1 - 3.4 6.2 39.1 4 6.0 39.1 1.1 1 0 0 1 1 1 0 Hamartin protein SAPS PF04499.15 CDI88014.1 - 5.6 5.6 33.7 6.8 5.4 33.7 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CAC1F_C PF16885.5 CDI88014.1 - 8.6 5.9 30.6 11 5.6 30.6 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term PRP38_assoc PF12871.7 CDI88015.1 - 0.73 10.5 35.3 0.96 10.1 35.3 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF2776 PF10951.8 CDI88017.1 - 0.00025 20.4 0.3 0.00035 19.9 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2776) DUF726 PF05277.12 CDI88017.1 - 0.016 14.2 2.2 0.018 14.0 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) GET2 PF08690.10 CDI88017.1 - 0.024 14.3 20.5 0.028 14.1 20.5 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 PAT1 PF09770.9 CDI88017.1 - 0.15 10.3 34.1 0.16 10.2 34.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CTU2 PF10288.9 CDI88017.1 - 1.1 9.5 15.4 0.25 11.6 0.7 2.3 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 LMBR1 PF04791.16 CDI88017.1 - 1.6 7.5 7.3 1.8 7.3 7.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Gti1_Pac2 PF09729.9 CDI88017.1 - 1.9 8.6 13.6 2.8 8.0 13.6 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family O-antigen_lig PF13425.6 CDI88017.1 - 4.9 5.8 9.2 6.6 5.4 9.2 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Presenilin PF01080.17 CDI88017.1 - 5.5 5.7 23.0 7.5 5.2 23.0 1.1 1 0 0 1 1 1 0 Presenilin CCSAP PF15748.5 CDI88017.1 - 7 6.7 23.8 9.7 6.3 23.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Ripply PF14998.6 CDI88018.1 - 0.03 15.0 3.0 0.031 14.9 3.0 1.2 1 0 0 1 1 1 0 Transcription Regulator AbiH PF14253.6 CDI88018.1 - 0.21 11.4 1.5 0.23 11.3 1.5 1.0 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH Tam41_Mmp37 PF09139.11 CDI88018.1 - 0.22 10.9 6.1 0.24 10.8 6.1 1.0 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial DUF2448 PF10476.9 CDI88018.1 - 0.35 10.7 3.5 0.33 10.8 3.5 1.0 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) DUF5336 PF17270.2 CDI88018.1 - 0.74 9.4 9.5 0.9 9.1 9.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5336) BRF1 PF07741.13 CDI88018.1 - 0.78 10.1 8.4 0.87 10.0 8.4 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain EIIBC-GUT_N PF03612.14 CDI88018.1 - 1.5 8.6 5.8 1.5 8.6 5.8 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus WBP-1 PF11669.8 CDI88018.1 - 1.5 9.5 6.0 1.6 9.4 6.0 1.0 1 0 0 1 1 1 0 WW domain-binding protein 1 DUF2722 PF10846.8 CDI88018.1 - 2 7.3 16.8 1.8 7.4 16.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) ICE2 PF08426.10 CDI88018.1 - 2 7.5 3.3 2.1 7.4 3.3 1.0 1 0 0 1 1 1 0 ICE2 DUF3464 PF11947.8 CDI88018.1 - 2 8.1 5.9 2.1 8.1 5.9 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Spt20 PF12090.8 CDI88018.1 - 2.2 7.9 22.1 2.3 7.8 22.1 1.1 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI88018.1 - 2.2 9.3 6.1 2.1 9.4 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF775 PF05603.12 CDI88018.1 - 2.8 7.4 8.9 2.9 7.4 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Pex26 PF07163.12 CDI88018.1 - 3.3 6.9 11.0 3.5 6.8 11.0 1.0 1 0 0 1 1 1 0 Pex26 protein Perilipin PF03036.16 CDI88018.1 - 3.7 6.5 15.4 4 6.3 15.4 1.0 1 0 0 1 1 1 0 Perilipin family Gastrin PF00918.17 CDI88018.1 - 3.9 8.5 9.4 4.2 8.4 9.4 1.1 1 0 0 1 1 1 0 Gastrin/cholecystokinin family 7tm_7 PF08395.12 CDI88018.1 - 5 6.2 9.8 5.1 6.2 9.8 1.0 1 0 0 1 1 1 0 7tm Chemosensory receptor Presenilin PF01080.17 CDI88018.1 - 5.4 5.7 6.2 5.1 5.7 6.2 1.1 1 0 0 1 1 1 0 Presenilin DUF4543 PF15076.6 CDI88018.1 - 6.2 7.0 8.0 9.4 6.5 8.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4543) DUF1682 PF07946.14 CDI88018.1 - 6.3 5.9 9.9 6.1 5.9 9.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Suf PF05843.14 CDI88018.1 - 6.9 6.6 14.4 7.6 6.4 14.4 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Exonuc_VII_L PF02601.15 CDI88019.1 - 2.5e-06 27.3 3.0 3e-06 27.0 3.0 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit Pex14_N PF04695.13 CDI88019.1 - 0.0004 21.1 24.8 0.0004 21.1 24.8 2.6 2 1 0 2 2 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region AUX_IAA PF02309.16 CDI88019.1 - 0.016 15.1 5.9 0.02 14.8 5.9 1.2 1 0 0 1 1 1 0 AUX/IAA family CCSAP PF15748.5 CDI88019.1 - 0.058 13.6 20.2 0.095 12.9 20.2 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SID-1_RNA_chan PF13965.6 CDI88019.1 - 0.074 11.5 0.9 0.077 11.4 0.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4628 PF15429.6 CDI88019.1 - 0.12 12.1 16.5 0.19 11.4 16.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) VIR_N PF15912.5 CDI88019.1 - 0.21 11.1 14.3 0.35 10.4 14.3 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Fumble PF03630.14 CDI88019.1 - 0.23 10.6 2.6 0.28 10.3 2.6 1.1 1 0 0 1 1 1 0 Fumble PAT1 PF09770.9 CDI88019.1 - 0.29 9.4 35.2 0.37 9.0 35.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TCP PF03634.13 CDI88019.1 - 0.34 11.5 17.0 0.54 10.8 17.0 1.3 1 0 0 1 1 1 0 TCP family transcription factor Suf PF05843.14 CDI88019.1 - 0.38 10.7 24.2 0.67 9.9 24.2 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hid1 PF12722.7 CDI88019.1 - 0.52 8.4 16.2 0.63 8.1 16.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDK5_activator PF03261.15 CDI88019.1 - 0.72 9.3 13.7 0.93 9.0 13.7 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Ribosomal_60s PF00428.19 CDI88019.1 - 0.73 10.5 23.7 1.8 9.2 4.5 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Neur_chan_memb PF02932.16 CDI88019.1 - 0.75 9.8 14.3 1.1 9.3 14.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SAGA-Tad1 PF12767.7 CDI88019.1 - 0.8 9.4 16.8 1.1 8.9 16.8 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit RR_TM4-6 PF06459.12 CDI88019.1 - 0.82 9.4 20.9 1.1 9.0 20.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.6 CDI88019.1 - 0.98 9.4 15.2 1.4 8.9 15.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Lin-8 PF03353.15 CDI88019.1 - 1.2 8.7 26.6 1.6 8.2 26.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PTPRCAP PF15713.5 CDI88019.1 - 1.4 9.2 20.5 2.3 8.5 20.5 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated NPR3 PF03666.13 CDI88019.1 - 1.4 7.7 16.9 1.7 7.3 16.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 eIF-3_zeta PF05091.12 CDI88019.1 - 1.5 7.7 24.8 2 7.3 24.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GREB1 PF15782.5 CDI88019.1 - 1.6 5.7 23.2 2 5.4 23.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Tim54 PF11711.8 CDI88019.1 - 1.7 7.4 15.9 2.4 6.9 15.9 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF5427 PF10310.9 CDI88019.1 - 1.7 7.5 22.4 2.6 6.9 22.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF2464 PF10240.9 CDI88019.1 - 1.9 8.0 11.6 2.7 7.5 11.6 1.3 1 0 0 1 1 1 0 Multivesicular body subunit 12 Endostatin PF06482.11 CDI88019.1 - 1.9 7.8 18.8 2.7 7.4 18.8 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF3295 PF11702.8 CDI88019.1 - 2.1 7.6 22.2 3.1 7.1 22.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Membralin PF09746.9 CDI88019.1 - 2.4 7.1 11.2 3.2 6.7 11.2 1.1 1 0 0 1 1 1 0 Tumour-associated protein SpoIIP PF07454.11 CDI88019.1 - 2.6 7.4 18.5 5.3 6.4 18.5 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF3292 PF11696.8 CDI88019.1 - 2.9 6.2 12.6 4.7 5.5 12.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) AAA_23 PF13476.6 CDI88019.1 - 3.1 8.2 17.8 4.2 7.8 17.8 1.2 1 0 0 1 1 1 0 AAA domain Auxin_canalis PF05703.11 CDI88019.1 - 3.7 7.4 22.4 0.081 12.8 8.4 2.3 2 0 0 2 2 2 0 Auxin canalisation CDC45 PF02724.14 CDI88019.1 - 4.5 5.5 18.2 6 5.0 18.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.9 CDI88019.1 - 4.5 5.7 15.5 6.9 5.1 15.5 1.2 1 0 0 1 1 1 0 Macoilin family DUF4175 PF13779.6 CDI88019.1 - 5 4.9 52.1 8.3 4.2 52.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Presenilin PF01080.17 CDI88019.1 - 5.3 5.7 27.8 7.4 5.2 27.8 1.1 1 0 0 1 1 1 0 Presenilin DUF4746 PF15928.5 CDI88019.1 - 6.7 6.0 14.8 9.3 5.6 14.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PA26 PF04636.13 CDI88019.1 - 8.9 5.1 15.6 12 4.7 15.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) BORG_CEP PF14957.6 CDI88019.1 - 9.7 7.4 14.5 18 6.5 14.5 1.5 1 0 0 1 1 1 0 Cdc42 effector DSPc PF00782.20 CDI88020.1 - 1.7e-10 40.8 0.0 2.5e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Secretin_N_2 PF07655.13 CDI88020.1 - 6.7e-05 23.4 6.5 9.6e-05 22.9 6.5 1.2 1 0 0 1 1 1 1 Secretin N-terminal domain Y_phosphatase PF00102.27 CDI88020.1 - 0.00037 20.1 0.0 0.00042 19.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CDI88020.1 - 0.00077 19.6 0.0 0.00099 19.2 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate TatD_DNase PF01026.21 CDI88020.1 - 0.0099 15.3 0.0 0.011 15.2 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Y_phosphatase3 PF13350.6 CDI88020.1 - 0.13 12.2 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF515 PF04415.12 CDI88020.1 - 0.82 8.0 4.4 0.99 7.7 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) GAS PF13851.6 CDI88021.1 - 3.4e-05 23.3 23.3 0.00031 20.1 3.5 3.1 3 0 0 3 3 3 2 Growth-arrest specific micro-tubule binding HOOK PF05622.12 CDI88021.1 - 0.0007 17.9 4.1 0.0007 17.9 4.1 2.1 1 1 1 2 2 2 1 HOOK protein HALZ PF02183.18 CDI88021.1 - 0.0013 19.0 27.8 0.0045 17.2 1.6 5.2 5 0 0 5 5 5 1 Homeobox associated leucine zipper DUF2046 PF09755.9 CDI88021.1 - 0.0013 18.1 16.2 0.0052 16.1 2.2 2.5 1 1 1 2 2 2 2 Uncharacterized conserved protein H4 (DUF2046) APG6_N PF17675.1 CDI88021.1 - 0.0028 18.2 22.5 0.32 11.5 4.2 3.2 3 0 0 3 3 3 1 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 CDI88021.1 - 0.0041 17.1 23.0 0.054 13.5 0.2 3.2 3 0 0 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SOGA PF11365.8 CDI88021.1 - 0.005 17.9 11.9 0.041 15.0 1.1 2.7 2 1 1 3 3 3 1 Protein SOGA HR1 PF02185.16 CDI88021.1 - 0.018 15.1 1.3 0.018 15.1 1.3 3.2 3 1 0 3 3 3 0 Hr1 repeat Spc7 PF08317.11 CDI88021.1 - 0.025 13.5 20.1 0.22 10.4 4.2 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Fez1 PF06818.15 CDI88021.1 - 0.028 14.9 14.7 0.075 13.5 14.2 2.0 1 1 0 1 1 1 0 Fez1 DUF4407 PF14362.6 CDI88021.1 - 0.029 13.7 21.6 2.2 7.6 21.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) PRKG1_interact PF15898.5 CDI88021.1 - 0.038 14.9 20.7 0.27 12.2 2.0 3.4 2 1 0 3 3 3 0 cGMP-dependent protein kinase interacting domain OmdA PF13376.6 CDI88021.1 - 0.042 13.8 5.8 0.97 9.5 0.6 2.8 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated TMF_TATA_bd PF12325.8 CDI88021.1 - 0.06 13.6 22.2 0.26 11.5 3.4 3.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Lzipper-MIP1 PF14389.6 CDI88021.1 - 0.066 13.5 14.4 0.43 10.9 3.9 3.1 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 bZIP_1 PF00170.21 CDI88021.1 - 0.092 12.9 21.3 2.5 8.3 2.7 4.9 4 1 1 5 5 5 0 bZIP transcription factor Phage_GP20 PF06810.11 CDI88021.1 - 0.1 12.4 27.0 1.8 8.3 7.1 3.1 3 0 0 3 3 3 0 Phage minor structural protein GP20 TPD52 PF04201.15 CDI88021.1 - 0.18 11.4 10.2 0.18 11.4 0.3 3.1 3 0 0 3 3 3 0 Tumour protein D52 family MbeD_MobD PF04899.12 CDI88021.1 - 0.19 11.9 9.6 1.1 9.4 0.9 3.4 3 1 0 3 3 3 0 MbeD/MobD like YabA PF06156.13 CDI88021.1 - 0.24 12.1 14.0 4.1 8.1 0.5 3.2 2 1 1 3 3 3 0 Initiation control protein YabA TSC22 PF01166.18 CDI88021.1 - 0.26 11.6 11.2 2.4 8.5 1.6 3.6 3 1 1 4 4 4 0 TSC-22/dip/bun family DUF1664 PF07889.12 CDI88021.1 - 0.35 10.9 6.7 1.1 9.3 1.9 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) CENP-H PF05837.12 CDI88021.1 - 0.4 11.1 16.1 1.1 9.7 1.4 3.3 3 0 0 3 3 3 0 Centromere protein H (CENP-H) Rho_Binding PF08912.11 CDI88021.1 - 0.49 11.3 26.3 1.2 10.0 0.2 3.5 3 1 0 3 3 3 0 Rho Binding KASH_CCD PF14662.6 CDI88021.1 - 0.51 10.1 24.7 1.9 8.3 3.0 2.9 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH LOH1CR12 PF10158.9 CDI88021.1 - 0.53 10.3 8.2 2.3 8.2 0.4 3.0 3 0 0 3 3 3 0 Tumour suppressor protein TDA11 PF17084.5 CDI88021.1 - 0.68 8.8 4.6 0.49 9.3 0.6 2.0 2 0 0 2 2 2 0 Topoisomerase I damage affected protein 11 MAD PF05557.13 CDI88021.1 - 0.7 8.2 18.3 1.4 7.2 8.1 2.8 2 1 1 3 3 3 0 Mitotic checkpoint protein WDCP PF15390.6 CDI88021.1 - 0.72 8.2 5.9 1.5 7.1 5.4 1.6 1 1 0 1 1 1 0 WD repeat and coiled-coil-containing protein family CCDC-167 PF15188.6 CDI88021.1 - 0.74 10.2 18.7 5.3 7.5 2.0 3.3 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 167 DivIC PF04977.15 CDI88021.1 - 0.94 9.3 28.5 0.29 10.9 6.7 3.9 3 2 0 3 3 3 0 Septum formation initiator HIP1_clath_bdg PF16515.5 CDI88021.1 - 1 10.0 23.3 0.31 11.7 3.7 3.3 3 1 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ATG16 PF08614.11 CDI88021.1 - 1.2 9.3 26.5 8.1 6.6 6.7 3.0 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Cnn_1N PF07989.11 CDI88021.1 - 1.3 9.3 16.5 3.7 7.8 1.6 4.0 2 2 1 3 3 3 0 Centrosomin N-terminal motif 1 Seadorna_VP6 PF07407.11 CDI88021.1 - 1.5 7.7 8.4 1.1 8.1 0.9 2.1 2 0 0 2 2 2 0 Seadornavirus VP6 protein NYD-SP28_assoc PF14775.6 CDI88021.1 - 1.6 8.9 15.6 0.083 13.0 5.1 3.1 4 0 0 4 4 3 0 Sperm tail C-terminal domain NPV_P10 PF05531.12 CDI88021.1 - 1.8 9.0 10.9 0.72 10.4 1.4 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein JIP_LZII PF16471.5 CDI88021.1 - 2 8.7 17.6 9 6.6 4.3 4.5 3 2 0 4 4 4 0 JNK-interacting protein leucine zipper II FliD_N PF02465.18 CDI88021.1 - 2.2 9.0 18.7 4 8.2 4.5 2.7 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus FapA PF03961.13 CDI88021.1 - 2.3 6.7 10.7 3.3 6.2 3.0 2.2 2 1 0 2 2 2 0 Flagellar Assembly Protein A Fzo_mitofusin PF04799.13 CDI88021.1 - 2.3 7.7 16.1 1 8.9 3.4 2.9 3 0 0 3 3 3 0 fzo-like conserved region bZIP_Maf PF03131.17 CDI88021.1 - 2.4 8.7 19.8 5.8 7.5 4.7 3.5 3 1 0 3 3 3 0 bZIP Maf transcription factor Occludin_ELL PF07303.13 CDI88021.1 - 2.9 8.7 15.9 1.3 9.8 2.7 3.0 3 0 0 3 3 3 0 Occludin homology domain Seryl_tRNA_N PF02403.22 CDI88021.1 - 3.1 8.1 24.4 2.9 8.2 5.1 3.3 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3810 PF12725.7 CDI88021.1 - 3.6 6.9 8.9 2 7.7 2.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) ZapB PF06005.12 CDI88021.1 - 5.4 7.5 30.3 16 6.0 9.9 3.9 3 2 0 3 3 3 0 Cell division protein ZapB Fmp27_WPPW PF10359.9 CDI88021.1 - 5.5 5.7 11.4 7.6 5.3 4.0 2.3 2 1 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain ERM PF00769.19 CDI88021.1 - 5.7 6.7 30.7 1.8 8.3 14.1 2.8 2 1 0 2 2 2 0 Ezrin/radixin/moesin family HU-CCDC81_bac_2 PF18175.1 CDI88021.1 - 5.9 6.8 11.8 0.37 10.7 1.2 3.2 3 1 1 4 4 4 0 CCDC81-like prokaryotic HU domain 2 Bcr-Abl_Oligo PF09036.10 CDI88021.1 - 6.7 6.8 6.3 3.4 7.7 0.2 2.9 3 0 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Presenilin PF01080.17 CDI88022.1 - 0.81 8.4 15.9 0.86 8.3 15.9 1.1 1 0 0 1 1 1 0 Presenilin DUF5113 PF17140.4 CDI88023.1 - 0.0009 19.1 2.4 0.0013 18.6 2.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5113) SUIM_assoc PF16619.5 CDI88023.1 - 0.037 14.1 6.4 0.037 14.1 6.4 4.2 3 1 1 4 4 1 0 Unstructured region C-term to UIM in Ataxin3 PBP1_TM PF14812.6 CDI88023.1 - 0.061 13.7 1.8 0.12 12.7 0.2 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4366 PF14283.6 CDI88023.1 - 0.072 13.1 3.8 0.19 11.8 3.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) Kei1 PF08552.11 CDI88023.1 - 0.076 12.9 3.0 0.12 12.2 3.0 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Presenilin PF01080.17 CDI88023.1 - 0.08 11.7 7.0 0.091 11.5 7.0 1.2 1 0 0 1 1 1 0 Presenilin DcuC PF03606.15 CDI88023.1 - 0.082 11.3 3.3 0.026 13.0 0.9 1.4 1 1 1 2 2 2 0 C4-dicarboxylate anaerobic carrier DUF3382 PF11862.8 CDI88023.1 - 0.11 12.8 3.2 0.14 12.5 2.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3382) FAM60A PF15396.6 CDI88023.1 - 0.12 12.3 3.4 0.17 11.9 3.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Zip PF02535.22 CDI88023.1 - 0.13 11.4 0.3 0.17 11.1 0.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Suf PF05843.14 CDI88023.1 - 0.21 11.6 15.4 0.27 11.2 15.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) HCO3_cotransp PF00955.21 CDI88023.1 - 0.22 10.3 1.0 0.26 10.1 1.0 1.0 1 0 0 1 1 1 0 HCO3- transporter family DUF979 PF06166.12 CDI88023.1 - 0.25 10.5 1.0 0.33 10.1 1.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF979) DUF1345 PF07077.11 CDI88023.1 - 0.29 10.8 3.2 1.1 8.9 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) CrgA PF06781.12 CDI88023.1 - 0.68 10.0 2.1 1.6 8.8 0.3 2.1 2 0 0 2 2 2 0 Cell division protein CrgA CAF1 PF04857.20 CDI88023.1 - 0.7 9.0 8.5 0.8 8.8 8.5 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease DDHD PF02862.17 CDI88023.1 - 0.75 9.9 6.2 0.95 9.6 6.2 1.2 1 0 0 1 1 1 0 DDHD domain Hydin_ADK PF17213.3 CDI88023.1 - 1 9.6 7.5 1.2 9.4 7.5 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Neur_chan_memb PF02932.16 CDI88023.1 - 1 9.4 5.3 1.1 9.3 5.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CLN3 PF02487.17 CDI88023.1 - 1.3 8.0 5.4 1.6 7.7 5.4 1.1 1 0 0 1 1 1 0 CLN3 protein LAP1C PF05609.12 CDI88023.1 - 1.4 8.0 15.1 1.5 7.8 15.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Orf78 PF06024.12 CDI88023.1 - 2.1 8.7 10.4 0.096 13.0 1.7 2.2 1 1 1 2 2 2 0 Orf78 (ac78) DcuA_DcuB PF03605.14 CDI88023.1 - 3.3 6.5 4.7 0.57 9.0 1.1 1.5 1 1 1 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Mss4 PF04421.13 CDI88023.1 - 3.9 7.7 5.3 25 5.1 1.6 2.3 2 0 0 2 2 2 0 Mss4 protein TAF4 PF05236.14 CDI88024.1 - 4.7 6.9 29.4 5.8 6.6 29.4 1.0 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family FAM60A PF15396.6 CDI88024.1 - 8.2 6.4 10.2 9.6 6.1 10.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Trypan_PARP PF05887.11 CDI88025.1 - 2.3 8.2 38.9 0.2 11.7 4.9 3.1 2 1 1 3 3 3 0 Procyclic acidic repetitive protein (PARP) WW PF00397.26 CDI88026.1 - 1.6e-05 24.8 0.5 3.6e-05 23.8 0.5 1.6 1 0 0 1 1 1 1 WW domain DUF572 PF04502.13 CDI88026.1 - 0.35 10.4 31.1 0.43 10.2 31.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) GREB1 PF15782.5 CDI88026.1 - 0.44 7.6 35.8 0.45 7.6 35.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2681 PF10883.8 CDI88026.1 - 0.52 10.7 28.4 0.27 11.6 6.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) SOBP PF15279.6 CDI88026.1 - 1.6 9.3 24.3 2 8.9 24.3 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Ndc1_Nup PF09531.10 CDI88026.1 - 1.6 7.3 29.1 2 7.0 29.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SPX PF03105.19 CDI88026.1 - 2.2 8.1 37.2 2.8 7.7 37.2 1.2 1 0 0 1 1 1 0 SPX domain PAT1 PF09770.9 CDI88026.1 - 2.3 6.4 30.0 2.7 6.2 30.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SWI-SNF_Ssr4 PF08549.10 CDI88026.1 - 2.8 6.5 30.2 3.4 6.2 30.2 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) PI3K_1B_p101 PF10486.9 CDI88026.1 - 6.2 4.5 33.2 1 7.0 29.5 1.4 1 1 1 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit MscS_TM PF12794.7 CDI88028.1 - 0.00093 18.1 5.2 0.0018 17.2 5.2 1.6 1 0 0 1 1 1 1 Mechanosensitive ion channel inner membrane domain 1 DUF572 PF04502.13 CDI88028.1 - 1.1 8.9 48.3 1.7 8.2 48.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF3169 PF11368.8 CDI88028.1 - 1.1 8.8 13.0 3.1 7.3 1.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) DUF2214 PF09980.9 CDI88028.1 - 2 8.2 3.4 4 7.2 3.1 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2214) DUF2232 PF09991.9 CDI88028.1 - 2.6 7.1 8.4 0.14 11.4 3.3 1.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) DUF4199 PF13858.6 CDI88028.1 - 2.7 8.4 13.8 0.065 13.6 4.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4199) Utp14 PF04615.13 CDI88028.1 - 2.9 6.4 57.2 3.8 6.0 57.2 1.1 1 0 0 1 1 1 0 Utp14 protein Caldesmon PF02029.15 CDI88028.1 - 3 6.5 44.2 4.1 6.1 44.2 1.1 1 0 0 1 1 1 0 Caldesmon Spt20 PF12090.8 CDI88029.1 - 1.1e-05 25.2 28.3 0.0008 19.1 15.7 2.4 2 0 0 2 2 2 2 Spt20 family ST7 PF04184.12 CDI88029.1 - 0.39 9.1 4.3 2 6.8 0.3 2.1 2 0 0 2 2 2 0 ST7 protein TFIIA PF03153.13 CDI88029.1 - 0.83 9.6 47.5 0.32 10.9 27.3 2.1 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF2681 PF10883.8 CDI88029.1 - 2.3 8.7 23.0 0.22 11.9 7.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Med15 PF09606.10 CDI88029.1 - 3.3 6.3 30.7 3.5 6.2 4.3 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF664 PF04978.12 CDI88030.1 - 0.026 14.9 7.5 0.028 14.8 7.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF664) PUD1_2 PF18457.1 CDI88030.1 - 0.32 11.0 3.4 0.39 10.7 3.4 1.0 1 0 0 1 1 1 0 Up-Regulated in long-lived daf-2 Ribosomal_60s PF00428.19 CDI88030.1 - 0.32 11.6 13.8 0.44 11.2 13.7 1.3 1 1 0 1 1 1 0 60s Acidic ribosomal protein DUF3292 PF11696.8 CDI88030.1 - 0.72 8.2 6.7 0.81 8.0 6.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Spt20 PF12090.8 CDI88030.1 - 1.1 8.8 21.6 1.3 8.6 21.6 1.0 1 0 0 1 1 1 0 Spt20 family VIT1 PF01988.19 CDI88030.1 - 3.2 7.5 7.8 3.5 7.4 7.8 1.0 1 0 0 1 1 1 0 VIT family DUF2722 PF10846.8 CDI88030.1 - 3.5 6.5 14.6 4.2 6.2 14.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF702 PF05142.12 CDI88030.1 - 4.7 7.7 12.0 5.3 7.5 12.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Histone_HNS PF00816.21 CDI88030.1 - 6.4 7.7 14.0 8.2 7.3 14.0 1.2 1 0 0 1 1 1 0 H-NS histone family CDC45 PF02724.14 CDI88033.1 - 0.0025 16.2 22.6 0.0033 15.8 22.6 1.1 1 0 0 1 1 1 1 CDC45-like protein DUF4604 PF15377.6 CDI88033.1 - 0.0047 17.4 22.3 0.0066 16.9 22.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Shisa PF13908.6 CDI88033.1 - 0.011 16.0 14.6 0.011 16.0 14.6 2.0 1 1 1 2 2 1 0 Wnt and FGF inhibitory regulator DUF2151 PF10221.9 CDI88033.1 - 0.088 11.4 17.5 0.11 11.1 17.5 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator SpoIIP PF07454.11 CDI88033.1 - 0.092 12.2 32.8 0.6 9.5 25.8 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) PBP1_TM PF14812.6 CDI88033.1 - 0.092 13.1 14.1 0.092 13.1 10.2 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RNA_pol_Rpc4 PF05132.14 CDI88033.1 - 0.28 11.6 25.7 0.029 14.8 16.0 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 Afi1 PF07792.12 CDI88033.1 - 0.55 10.7 30.1 0.63 10.5 22.3 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Hid1 PF12722.7 CDI88033.1 - 0.57 8.3 28.4 0.69 8.0 28.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AF-4 PF05110.13 CDI88033.1 - 0.62 8.1 35.6 0.86 7.6 35.6 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4366 PF14283.6 CDI88033.1 - 1.7 8.7 25.5 3.2 7.8 15.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) DUF3807 PF12720.7 CDI88033.1 - 2.6 8.3 45.3 4.3 7.6 35.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) PRIMA1 PF16101.5 CDI88034.1 - 0.73 9.9 9.2 1.3 9.0 9.2 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 eIF-3_zeta PF05091.12 CDI88035.1 - 0.015 14.3 12.7 0.017 14.1 12.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spt20 PF12090.8 CDI88035.1 - 0.018 14.6 22.0 0.026 14.1 22.0 1.3 1 0 0 1 1 1 0 Spt20 family DUF4175 PF13779.6 CDI88035.1 - 0.031 12.2 19.9 0.031 12.2 19.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF5523 PF17661.1 CDI88035.1 - 0.034 13.8 12.5 0.041 13.6 12.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) TFIIA PF03153.13 CDI88035.1 - 0.1 12.6 21.7 0.1 12.6 21.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CLN3 PF02487.17 CDI88035.1 - 0.17 10.9 5.7 0.19 10.7 5.7 1.1 1 0 0 1 1 1 0 CLN3 protein DUF2722 PF10846.8 CDI88035.1 - 0.17 10.8 16.6 0.2 10.6 16.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DDHD PF02862.17 CDI88035.1 - 0.2 11.8 10.9 0.24 11.5 10.9 1.1 1 0 0 1 1 1 0 DDHD domain DUF1115 PF06544.12 CDI88035.1 - 0.21 11.7 9.3 0.33 11.1 9.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) Band_3_cyto PF07565.13 CDI88035.1 - 0.23 11.3 9.2 0.31 10.8 9.2 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF913 PF06025.12 CDI88035.1 - 0.57 9.1 8.1 0.72 8.8 8.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PIG-S PF10510.9 CDI88035.1 - 0.63 8.8 9.4 0.71 8.6 9.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein CobT PF06213.12 CDI88035.1 - 0.68 9.3 17.9 1.2 8.5 17.9 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4746 PF15928.5 CDI88035.1 - 0.78 9.1 8.3 0.89 8.9 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF2828 PF11443.8 CDI88035.1 - 0.97 7.4 11.5 1.1 7.3 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Zip PF02535.22 CDI88035.1 - 1.1 8.4 5.2 1 8.5 5.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CNDH2_C PF16858.5 CDI88035.1 - 1.2 9.0 17.7 1.4 8.7 17.7 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Presenilin PF01080.17 CDI88035.1 - 1.2 7.8 13.3 1.2 7.8 13.3 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 CDI88035.1 - 1.4 7.7 12.6 1.4 7.6 12.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Dsh_C PF12316.8 CDI88035.1 - 1.6 9.1 6.3 1.9 8.9 6.3 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Connexin PF00029.19 CDI88035.1 - 1.9 8.2 9.4 2.5 7.8 9.4 1.2 1 0 0 1 1 1 0 Connexin Serinc PF03348.15 CDI88035.1 - 2.2 7.1 6.1 2.3 7.0 6.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) BORG_CEP PF14957.6 CDI88035.1 - 2.4 9.3 10.6 3.1 9.0 10.6 1.2 1 0 0 1 1 1 0 Cdc42 effector DUF4820 PF16091.5 CDI88035.1 - 3.6 6.9 10.4 5 6.4 10.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) SLC12 PF03522.15 CDI88035.1 - 4.5 6.2 12.7 5 6.0 12.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CSG2 PF16965.5 CDI88035.1 - 4.7 6.1 4.8 5.1 5.9 4.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator FAM60A PF15396.6 CDI88035.1 - 5.7 6.9 12.7 7 6.6 12.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Neur_chan_memb PF02932.16 CDI88035.1 - 6.2 6.8 8.7 7.1 6.6 8.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sec62 PF03839.16 CDI88035.1 - 6.4 6.2 8.7 7.2 6.1 8.7 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Folate_carrier PF01770.18 CDI88035.1 - 7.6 5.2 5.5 9.5 4.8 5.5 1.2 1 0 0 1 1 1 0 Reduced folate carrier V_ATPase_I PF01496.19 CDI88035.1 - 7.7 4.3 16.2 9.8 4.0 16.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EIIBC-GUT_N PF03612.14 CDI88035.1 - 8.8 6.0 9.5 13 5.5 9.5 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus UPF0542 PF15086.6 CDI88036.1 - 0.012 15.5 0.1 0.03 14.2 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 Tmemb_9 PF05434.11 CDI88036.1 - 0.022 14.7 2.1 0.022 14.7 2.1 3.0 1 1 1 2 2 2 0 TMEM9 SprA-related PF12118.8 CDI88036.1 - 0.068 12.3 32.9 0.088 11.9 32.9 1.1 1 0 0 1 1 1 0 SprA-related family Otopetrin PF03189.13 CDI88036.1 - 2.9 6.6 13.8 4.3 6.0 13.8 1.3 1 0 0 1 1 1 0 Otopetrin RR_TM4-6 PF06459.12 CDI88036.1 - 6 6.6 18.6 0.75 9.6 5.5 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.13 CDI88038.1 - 0.013 15.6 23.8 0.015 15.3 23.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PIG-S PF10510.9 CDI88038.1 - 0.051 12.4 11.0 0.065 12.1 11.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein MPM1 PF17234.2 CDI88038.1 - 0.15 12.3 7.9 0.22 11.7 7.9 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Macoilin PF09726.9 CDI88038.1 - 0.23 10.0 14.0 0.28 9.7 14.0 1.0 1 0 0 1 1 1 0 Macoilin family Plasmodium_Vir PF05795.11 CDI88038.1 - 0.51 9.7 5.7 0.57 9.5 5.7 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein NST1 PF13945.6 CDI88038.1 - 0.54 10.3 19.7 0.22 11.6 17.2 1.5 1 1 1 2 2 2 0 Salt tolerance down-regulator ATF7IP_BD PF16788.5 CDI88038.1 - 0.55 10.3 20.9 0.68 10.0 20.9 1.1 1 0 0 1 1 1 0 ATF-interacting protein binding domain DUF3112 PF11309.8 CDI88038.1 - 0.57 9.6 5.8 0.7 9.3 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) DUF3439 PF11921.8 CDI88038.1 - 0.57 10.2 18.0 0.24 11.4 14.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Presenilin PF01080.17 CDI88038.1 - 1.9 7.2 14.2 2.5 6.7 14.2 1.2 1 0 0 1 1 1 0 Presenilin SRP-alpha_N PF04086.13 CDI88038.1 - 2.8 7.8 14.0 3.5 7.5 14.0 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SLC12 PF03522.15 CDI88038.1 - 4.3 6.3 10.1 4.7 6.1 10.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Lin-8 PF03353.15 CDI88038.1 - 4.9 6.6 14.0 6 6.3 14.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SOG2 PF10428.9 CDI88038.1 - 5 6.2 26.1 6.4 5.8 26.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 CDI88038.1 - 5.1 6.9 20.3 6.1 6.7 20.3 1.0 1 0 0 1 1 1 0 SPX domain Itfg2 PF15907.5 CDI88038.1 - 5.5 5.9 7.5 6.7 5.6 7.5 1.1 1 0 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 API5 PF05918.11 CDI88038.1 - 5.9 5.6 9.2 7.1 5.3 9.2 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Gastrin PF00918.17 CDI88038.1 - 6.2 7.8 9.5 8.7 7.3 9.5 1.3 1 0 0 1 1 1 0 Gastrin/cholecystokinin family Zip PF02535.22 CDI88038.1 - 7.8 5.6 9.3 9.4 5.3 9.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Hid1 PF12722.7 CDI88038.1 - 9.2 4.2 12.0 10 4.1 12.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Activator_LAG-3 PF11498.8 CDI88039.1 - 0.01 14.8 52.8 0.02 13.9 52.8 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.13 CDI88039.1 - 2.3 8.1 41.9 5.2 7.0 41.9 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_23 PF13476.6 CDI88039.1 - 5 7.6 19.9 7.8 6.9 19.9 1.3 1 0 0 1 1 1 0 AAA domain V_ATPase_I PF01496.19 CDI88040.1 - 0.00049 18.2 4.6 0.00056 18.0 4.6 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family O-antigen_lig PF13425.6 CDI88040.1 - 0.016 14.0 0.4 0.021 13.6 0.4 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein HemX PF04375.14 CDI88040.1 - 0.022 14.1 1.1 0.025 13.9 1.1 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Zip PF02535.22 CDI88040.1 - 0.038 13.2 5.4 0.046 12.9 5.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SID-1_RNA_chan PF13965.6 CDI88040.1 - 0.12 10.8 0.1 0.12 10.8 0.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CLN3 PF02487.17 CDI88040.1 - 0.23 10.5 2.4 0.25 10.3 2.4 1.2 1 0 0 1 1 1 0 CLN3 protein PIP5K PF01504.18 CDI88040.1 - 0.3 10.3 3.7 0.34 10.1 3.7 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase BORG_CEP PF14957.6 CDI88040.1 - 0.35 12.0 5.2 0.42 11.8 5.2 1.2 1 0 0 1 1 1 0 Cdc42 effector Conotoxin PF02950.17 CDI88040.1 - 0.38 11.8 0.2 0.38 11.8 0.2 2.6 1 1 1 2 2 2 0 Conotoxin DUF2828 PF11443.8 CDI88040.1 - 0.52 8.3 8.7 0.67 8.0 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) TRAP_alpha PF03896.16 CDI88040.1 - 1.9 7.6 27.9 3.2e+02 0.3 27.9 2.0 1 1 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SAPS PF04499.15 CDI88040.1 - 2 7.1 13.4 2.2 6.9 13.4 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF913 PF06025.12 CDI88040.1 - 6.3 5.7 12.4 7.1 5.5 12.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 CDI88040.1 - 8.7 6.3 9.0 11 6.0 9.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF2207 PF09972.9 CDI88041.1 - 0.038 12.7 7.9 0.051 12.3 7.9 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) LAP1C PF05609.12 CDI88041.1 - 0.045 12.8 14.3 0.053 12.6 14.3 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF4400 PF14348.6 CDI88041.1 - 0.081 12.4 6.3 0.1 12.1 6.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) DDHD PF02862.17 CDI88041.1 - 0.16 12.1 5.1 0.17 12.0 5.1 1.1 1 0 0 1 1 1 0 DDHD domain LMBR1 PF04791.16 CDI88041.1 - 0.2 10.5 18.4 0.24 10.3 18.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Orf78 PF06024.12 CDI88041.1 - 1 9.7 16.9 29 5.0 16.9 2.2 1 1 0 1 1 1 0 Orf78 (ac78) TMEM154 PF15102.6 CDI88041.1 - 1.1 9.1 7.5 1.8 8.5 7.5 1.4 1 1 0 1 1 1 0 TMEM154 protein family Pex24p PF06398.11 CDI88041.1 - 1.3 8.0 10.8 1.6 7.7 10.8 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Tweety PF04906.13 CDI88041.1 - 2.8 6.5 24.9 3.9 6.0 24.9 1.3 1 0 0 1 1 1 0 Tweety KCH PF16944.5 CDI88041.1 - 6.5 6.4 10.4 14 5.3 10.4 1.6 1 1 0 1 1 1 0 Fungal potassium channel ABC2_membrane_2 PF12679.7 CDI88043.1 - 0.6 9.3 12.1 0.019 14.3 3.6 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein Methyltransf_34 PF11312.8 CDI88043.1 - 0.7 9.1 18.7 1 8.5 18.7 1.3 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase FAM176 PF14851.6 CDI88043.1 - 0.77 9.4 15.4 0.065 12.9 4.0 2.3 2 0 0 2 2 2 0 FAM176 family DUF898 PF05987.13 CDI88043.1 - 0.89 8.5 4.6 1.1 8.2 4.6 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Stevor PF17410.2 CDI88043.1 - 0.92 9.0 6.8 1.4 8.4 6.8 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Peroxin-13_N PF04088.13 CDI88043.1 - 1.1 9.6 18.2 0.4 10.9 6.0 2.2 2 0 0 2 2 2 0 Peroxin 13, N-terminal region eIF_4EBP PF05456.11 CDI88043.1 - 1.2 9.1 23.0 1.5 8.8 6.0 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) DUF3408 PF11888.8 CDI88043.1 - 1.3 9.2 27.5 0.14 12.3 8.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) TFB6 PF17110.5 CDI88043.1 - 1.8 8.3 12.3 0.67 9.7 4.0 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Paf1 PF03985.13 CDI88043.1 - 1.8 7.5 25.3 0.13 11.2 10.2 2.1 2 0 0 2 2 2 0 Paf1 Baculo_PP31 PF05311.11 CDI88043.1 - 2 7.9 32.5 0.56 9.6 8.8 2.1 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Apc15p PF05841.11 CDI88043.1 - 3.1 8.6 31.6 0.15 12.9 15.1 2.4 2 0 0 2 2 2 0 Apc15p protein DUF389 PF04087.14 CDI88043.1 - 4 7.5 9.9 2.5 8.1 6.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF389) TRM13 PF05206.14 CDI88043.1 - 4.7 6.7 17.7 4.4 6.8 7.3 2.1 2 0 0 2 2 2 0 Methyltransferase TRM13 AAA_23 PF13476.6 CDI88043.1 - 8.1 6.9 29.0 4.7 7.7 4.0 2.2 2 0 0 2 2 2 0 AAA domain RVT_1 PF00078.27 CDI88045.1 - 1.1e-14 54.5 0.2 1.3e-07 31.4 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CDI88045.1 - 0.00018 21.5 0.0 0.00032 20.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase SR-25 PF10500.9 CDI88047.1 - 0.0018 18.0 2.4 0.0021 17.7 2.4 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Sigma_reg_C PF13791.6 CDI88047.1 - 0.2 11.9 4.5 0.21 11.8 4.5 1.2 1 0 0 1 1 1 0 Sigma factor regulator C-terminal Spt20 PF12090.8 CDI88047.1 - 0.3 10.7 18.6 0.34 10.5 18.6 1.1 1 0 0 1 1 1 0 Spt20 family UPF0560 PF10577.9 CDI88047.1 - 1.3 7.4 13.9 1.4 7.3 13.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TFIIA PF03153.13 CDI88047.1 - 3.7 7.4 18.5 4 7.3 18.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI88049.1 - 0.96 9.0 17.3 1.5 8.3 17.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MRP-S27 PF10037.9 CDI88050.1 - 0.15 10.9 13.5 0.18 10.6 13.5 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 Dodecin PF07311.12 CDI88050.1 - 0.73 10.1 2.3 1.5 9.1 1.2 1.9 1 1 1 2 2 2 0 Dodecin DUF4407 PF14362.6 CDI88050.1 - 0.92 8.8 13.5 1.1 8.6 13.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MCU PF04678.13 CDI88050.1 - 1.8 8.6 11.6 2.7 8.1 11.6 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter TFIIA PF03153.13 CDI88050.1 - 2.9 7.8 36.2 3.6 7.5 36.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GET2 PF08690.10 CDI88050.1 - 6.2 6.4 16.2 8.1 6.0 16.2 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Activator_LAG-3 PF11498.8 CDI88051.1 - 0.58 9.1 13.1 1.2 8.0 13.1 1.5 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TAF8_C PF10406.9 CDI88053.1 - 9.7e-09 35.7 0.6 9.7e-09 35.7 0.6 3.7 4 0 0 4 4 4 1 Transcription factor TFIID complex subunit 8 C-term Adeno_PIX PF03955.14 CDI88053.1 - 0.013 15.7 1.1 0.013 15.7 1.1 1.5 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) Actin PF00022.19 CDI88053.1 - 0.064 11.9 7.1 0.18 10.4 7.1 1.7 1 1 0 1 1 1 0 Actin Hist_deacetyl PF00850.19 CDI88053.1 - 0.087 12.3 1.8 0.13 11.7 1.8 1.2 1 0 0 1 1 1 0 Histone deacetylase domain DUF4407 PF14362.6 CDI88053.1 - 0.12 11.7 20.6 0.18 11.1 20.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ribosomal_60s PF00428.19 CDI88053.1 - 1.1 9.9 10.5 3.1 8.5 10.5 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein PPL5 PF18168.1 CDI88053.1 - 2.1 7.6 8.1 0.34 10.2 3.8 1.7 2 0 0 2 2 2 0 Prim-pol family 5 Sec62 PF03839.16 CDI88053.1 - 2.3 7.7 9.9 1.1 8.8 5.4 2.0 2 0 0 2 2 2 0 Translocation protein Sec62 Med19 PF10278.9 CDI88053.1 - 7.7 6.4 11.0 0.51 10.2 4.8 1.9 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Pro-rich PF15240.6 CDI88054.1 - 0.0014 19.0 14.4 0.0017 18.6 14.4 1.1 1 0 0 1 1 1 1 Proline-rich DUF5437 PF17505.2 CDI88054.1 - 0.3 11.2 3.4 2.7 8.1 0.3 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5437) Tim54 PF11711.8 CDI88056.1 - 0.003 16.4 1.1 0.0034 16.2 1.1 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 DUF2235 PF09994.9 CDI88056.1 - 0.01 15.2 0.2 0.014 14.7 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) SARAF PF06682.12 CDI88056.1 - 0.015 15.0 2.3 0.016 14.8 2.3 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis IER PF05760.12 CDI88056.1 - 0.019 15.3 9.6 0.02 15.2 9.6 1.0 1 0 0 1 1 1 0 Immediate early response protein (IER) HVSL PF09749.9 CDI88056.1 - 0.028 13.9 0.7 0.035 13.6 0.7 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein FHIPEP PF00771.20 CDI88056.1 - 0.086 11.3 1.8 0.088 11.3 1.8 1.1 1 0 0 1 1 1 0 FHIPEP family Peptidase_M29 PF02073.15 CDI88056.1 - 0.11 11.2 2.3 0.12 11.2 2.3 1.1 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) DUF4175 PF13779.6 CDI88056.1 - 0.15 9.9 16.1 0.17 9.8 16.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) eIF-3_zeta PF05091.12 CDI88056.1 - 0.28 10.1 6.2 0.34 9.8 6.2 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ORC_WH_C PF18137.1 CDI88056.1 - 0.29 11.2 4.9 0.38 10.8 4.9 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal AUX_IAA PF02309.16 CDI88056.1 - 0.51 10.2 4.0 0.75 9.6 4.0 1.2 1 0 0 1 1 1 0 AUX/IAA family Presenilin PF01080.17 CDI88056.1 - 0.52 9.0 5.6 0.64 8.7 5.6 1.2 1 0 0 1 1 1 0 Presenilin JAB PF01398.21 CDI88056.1 - 1.2 9.1 5.4 1.2 9.1 3.8 1.7 1 1 1 2 2 2 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease HD_6 PF18019.1 CDI88056.1 - 1.7 8.7 6.1 2.6 8.1 6.1 1.4 1 1 0 1 1 1 0 HD domain DUF4834 PF16118.5 CDI88056.1 - 1.8 9.6 12.3 0.27 12.2 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Tau95_N PF17682.1 CDI88056.1 - 2.4 8.3 6.1 5.2 7.3 6.1 1.5 1 1 0 1 1 1 0 Tau95 Triple barrel domain FAM70 PF14967.6 CDI88056.1 - 3.2 7.1 6.1 3.6 7.0 6.1 1.1 1 0 0 1 1 1 0 FAM70 protein EIIBC-GUT_N PF03612.14 CDI88056.1 - 5.2 6.8 6.1 1.4 8.6 0.7 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus dsDNA_bind PF01984.20 CDI88056.1 - 5.7 7.3 23.8 5.4 7.3 12.4 2.2 2 0 0 2 2 2 0 Double-stranded DNA-binding domain ANAPC_CDC26 PF10471.9 CDI88056.1 - 6.6 7.7 31.7 0.41 11.5 11.1 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Med15 PF09606.10 CDI88056.1 - 6.7 5.3 29.2 8.2 5.0 29.2 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal MMR1 PF08505.10 CDI88056.1 - 8.4 6.6 11.3 12 6.1 11.3 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Trigger_C PF05698.14 CDI88057.1 - 9.2e-06 25.8 10.3 0.00043 20.3 5.6 2.0 1 1 1 2 2 2 2 Bacterial trigger factor protein (TF) C-terminus Rad54_N PF08658.10 CDI88057.1 - 0.029 14.5 2.7 0.034 14.3 2.7 1.1 1 0 0 1 1 1 0 Rad54 N terminal FcoT PF10862.8 CDI88057.1 - 0.045 13.4 0.8 4.5 6.9 0.0 2.3 1 1 1 2 2 2 0 FcoT-like thioesterase domain Fer4_16 PF13484.6 CDI88057.1 - 0.058 14.3 4.1 0.34 11.9 4.1 2.1 1 1 0 1 1 1 0 4Fe-4S double cluster binding domain CCDC71L PF15374.6 CDI88057.1 - 0.25 10.6 5.3 0.26 10.5 5.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L DUF5624 PF18538.1 CDI88057.1 - 0.67 10.1 6.5 0.72 10.0 3.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5624) SF3A2 PF16835.5 CDI88058.1 - 3.4e-26 91.4 0.0 5.6e-26 90.7 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 CDI88058.1 - 2.3e-07 31.0 1.4 4.3e-07 30.1 1.4 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type PPR_2 PF13041.6 CDI88059.1 - 1.5e-10 41.1 0.0 1.2e-05 25.4 0.0 4.7 4 1 2 6 6 6 2 PPR repeat family PPR PF01535.20 CDI88059.1 - 9.8e-09 34.9 6.2 0.025 14.8 0.0 6.4 7 0 0 7 7 7 2 PPR repeat PPR_long PF17177.4 CDI88059.1 - 8.5e-08 31.8 0.0 8.5e-08 31.8 0.0 4.1 3 2 2 5 5 5 1 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 CDI88059.1 - 0.061 13.4 0.0 3.2 7.9 0.0 3.6 3 1 1 4 4 4 0 Pentatricopeptide repeat domain TPR_3 PF07720.12 CDI88059.1 - 0.1 12.6 3.2 0.44 10.6 0.1 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat HEAT PF02985.22 CDI88060.1 - 0.016 15.4 0.0 0.048 13.9 0.0 1.8 1 0 0 1 1 1 0 HEAT repeat Androgen_recep PF02166.16 CDI88060.1 - 0.029 13.3 8.0 0.033 13.1 8.0 1.0 1 0 0 1 1 1 0 Androgen receptor TFIIA PF03153.13 CDI88060.1 - 0.034 14.2 6.6 0.036 14.1 6.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pneumo_att_G PF05539.11 CDI88060.1 - 0.05 13.2 2.2 0.055 13.1 2.2 1.0 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G ComFB PF10719.9 CDI88060.1 - 0.71 10.0 3.3 10 6.3 0.7 2.1 2 0 0 2 2 2 0 Late competence development protein ComFB Methyltransf_34 PF11312.8 CDI88061.1 - 0.004 16.4 0.0 0.0049 16.2 0.0 1.1 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Spt20 PF12090.8 CDI88061.1 - 0.2 11.3 15.9 0.095 12.3 7.3 2.0 2 0 0 2 2 2 0 Spt20 family DUF2722 PF10846.8 CDI88061.1 - 1.1 8.1 10.6 1.2 8.0 5.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI88061.1 - 1.7 8.8 24.8 3.7 7.7 1.8 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 M_domain PF12938.7 CDI88061.1 - 4.5 7.0 29.3 1.5 8.5 4.2 2.3 2 0 0 2 2 2 0 M domain of GW182 SIT PF15330.6 CDI88062.1 - 0.0066 16.9 3.0 0.0076 16.7 3.0 1.1 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT HemX PF04375.14 CDI88062.1 - 0.036 13.4 12.7 0.04 13.2 12.7 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4254 PF14063.6 CDI88062.1 - 0.066 13.0 8.8 0.12 12.2 8.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4254) GNT-I PF03071.15 CDI88062.1 - 0.075 11.8 2.0 0.083 11.6 2.0 1.0 1 0 0 1 1 1 0 GNT-I family DUF2572 PF10833.8 CDI88062.1 - 0.11 12.3 6.7 0.15 11.8 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) DUF3708 PF12501.8 CDI88062.1 - 0.14 12.0 4.9 0.18 11.6 4.9 1.2 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter RPA_interact_N PF14766.6 CDI88062.1 - 0.2 11.4 0.2 0.2 11.4 0.2 1.7 2 0 0 2 2 2 0 Replication protein A interacting N-terminal Ribosomal_L37 PF08561.10 CDI88062.1 - 0.38 11.3 5.9 0.47 11.0 5.9 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L37 Atg14 PF10186.9 CDI88062.1 - 0.63 9.1 10.8 0.71 8.9 10.8 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3450 PF11932.8 CDI88062.1 - 1.5 8.1 16.2 5.4 6.2 16.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) TFIIA PF03153.13 CDI88063.1 - 0.0024 18.0 14.0 0.0027 17.8 14.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI88063.1 - 0.0026 18.1 16.1 0.0035 17.6 16.1 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Protamine_P2 PF00841.19 CDI88063.1 - 0.019 15.4 8.9 0.028 14.9 8.9 1.2 1 0 0 1 1 1 0 Sperm histone P2 eIF-3_zeta PF05091.12 CDI88063.1 - 0.047 12.7 4.4 0.054 12.5 4.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Roughex PF06020.11 CDI88063.1 - 0.053 12.6 1.2 0.049 12.7 1.2 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Suf PF05843.14 CDI88063.1 - 0.057 13.4 4.5 0.057 13.4 4.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Peptidase_S49_N PF08496.10 CDI88063.1 - 0.14 12.3 3.3 0.18 11.8 3.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Presenilin PF01080.17 CDI88063.1 - 0.18 10.5 2.0 0.19 10.5 2.0 1.1 1 0 0 1 1 1 0 Presenilin FAD_binding_9 PF08021.11 CDI88063.1 - 0.21 11.8 3.4 0.083 13.1 1.2 1.4 1 1 0 1 1 1 0 Siderophore-interacting FAD-binding domain DUF5421 PF17458.2 CDI88063.1 - 0.39 10.1 7.0 0.53 9.6 7.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5421) DUF2722 PF10846.8 CDI88063.1 - 0.44 9.4 16.2 0.56 9.1 16.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF4834 PF16118.5 CDI88063.1 - 1.3 10.0 6.5 1.8 9.6 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI88063.1 - 1.6 8.3 23.7 2.1 7.9 23.7 1.1 1 0 0 1 1 1 0 Spt20 family UPF0560 PF10577.9 CDI88063.1 - 2 6.8 9.7 2.5 6.5 9.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Exo_endo_phos PF03372.23 CDI88063.1 - 2.1 7.8 4.6 2.9 7.3 4.6 1.5 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Activator_LAG-3 PF11498.8 CDI88063.1 - 5.2 5.9 23.7 7.1 5.5 23.7 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Coilin_N PF15862.5 CDI88063.1 - 5.7 6.7 10.2 7.8 6.3 10.2 1.2 1 0 0 1 1 1 0 Coilin N-terminus DUF3464 PF11947.8 CDI88063.1 - 9.7 5.9 9.0 16 5.2 9.0 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Sec62 PF03839.16 CDI88065.1 - 0.031 13.8 8.2 0.034 13.6 8.2 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 Borrelia_P83 PF05262.11 CDI88065.1 - 0.11 10.9 19.8 0.12 10.8 19.8 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein TFIIA PF03153.13 CDI88065.1 - 0.13 12.3 22.3 0.15 12.0 22.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 CDI88065.1 - 0.15 13.0 10.1 0.18 12.8 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EURL PF06937.11 CDI88065.1 - 0.16 11.3 11.4 0.19 11.1 11.4 1.0 1 0 0 1 1 1 0 EURL protein DUF2722 PF10846.8 CDI88065.1 - 0.29 10.1 18.1 0.34 9.8 18.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CDC45 PF02724.14 CDI88065.1 - 0.58 8.4 10.3 0.63 8.3 10.3 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.6 CDI88065.1 - 0.66 10.0 7.6 0.74 9.8 7.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF702 PF05142.12 CDI88065.1 - 0.82 10.1 8.5 0.96 9.9 8.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Pex14_N PF04695.13 CDI88065.1 - 1.2 9.8 13.8 1.4 9.6 13.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF775 PF05603.12 CDI88065.1 - 1.2 8.7 9.2 1.3 8.5 9.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) PepSY_TM PF03929.16 CDI88065.1 - 1.6 8.3 3.7 1.7 8.2 3.7 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Neur_chan_memb PF02932.16 CDI88065.1 - 1.6 8.7 6.8 1.9 8.5 6.8 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM176 PF14851.6 CDI88065.1 - 1.6 8.3 7.2 1.9 8.1 7.2 1.3 1 0 0 1 1 1 0 FAM176 family GBP_C PF02841.14 CDI88065.1 - 1.8 7.9 21.4 2 7.7 21.4 1.0 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Presenilin PF01080.17 CDI88065.1 - 2.2 6.9 10.3 2.4 6.8 10.3 1.0 1 0 0 1 1 1 0 Presenilin Folliculin PF11704.8 CDI88065.1 - 2.4 8.0 8.3 2.7 7.9 8.3 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport UPF0560 PF10577.9 CDI88065.1 - 2.5 6.5 12.8 2.6 6.5 12.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TERB2 PF15101.6 CDI88065.1 - 2.6 8.1 12.2 3.3 7.7 12.2 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4407 PF14362.6 CDI88065.1 - 2.8 7.2 18.4 3.6 6.9 18.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DDHD PF02862.17 CDI88065.1 - 3.1 7.9 8.1 3.3 7.8 8.1 1.1 1 0 0 1 1 1 0 DDHD domain Nup88 PF10168.9 CDI88065.1 - 3.7 5.2 15.1 4.3 5.0 15.1 1.0 1 0 0 1 1 1 0 Nuclear pore component Med15 PF09606.10 CDI88065.1 - 3.8 6.1 23.5 3.9 6.0 23.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal 5_nucleotid PF05761.14 CDI88065.1 - 4.2 6.2 11.2 5 5.9 11.2 1.0 1 0 0 1 1 1 0 5' nucleotidase family ALMT PF11744.8 CDI88065.1 - 4.4 6.0 8.1 4.6 5.9 8.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Ndc1_Nup PF09531.10 CDI88065.1 - 4.6 5.8 7.2 5 5.7 7.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ctr PF04145.15 CDI88065.1 - 5.4 7.6 6.5 6.6 7.3 6.5 1.1 1 0 0 1 1 1 0 Ctr copper transporter family UPF0242 PF06785.11 CDI88065.1 - 5.4 7.1 24.9 6.5 6.8 24.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Ribosomal_L37 PF08561.10 CDI88065.1 - 5.6 7.5 13.8 7.8 7.0 13.8 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L37 Stevor PF17410.2 CDI88066.1 - 0.019 14.5 3.1 0.024 14.2 3.1 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame eIF-3_zeta PF05091.12 CDI88066.1 - 1.6 7.6 13.6 1.8 7.5 13.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) HGTP_anticodon2 PF12745.7 CDI88066.1 - 2.1 7.8 13.9 3.2 7.2 13.9 1.2 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs ALMT PF11744.8 CDI88066.1 - 2.8 6.7 9.2 3.2 6.5 9.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 CDI88066.1 - 4.9 6.1 13.5 4.9 6.1 13.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Ndc1_Nup PF09531.10 CDI88066.1 - 5.6 5.5 16.8 7 5.2 16.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Plasmodium_Vir PF05795.11 CDI88066.1 - 6.3 6.1 7.1 8.3 5.7 7.1 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PAT1 PF09770.9 CDI88066.1 - 6.5 4.9 25.3 6.8 4.8 25.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FSA_C PF10479.9 CDI88066.1 - 7 4.7 14.2 9.4 4.2 14.2 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Sec62 PF03839.16 CDI88066.1 - 7.4 6.0 12.4 9.4 5.7 12.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF572 PF04502.13 CDI88066.1 - 8.8 5.8 18.7 12 5.5 18.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) V_ATPase_I PF01496.19 CDI88066.1 - 9.5 4.0 9.8 9.9 3.9 9.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Laminin_G_3 PF13385.6 CDI88067.1 - 6.4e-06 26.4 0.0 3.4e-05 24.1 0.0 2.0 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4834 PF16118.5 CDI88068.1 - 0.034 15.1 7.7 0.061 14.3 7.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TFIIA PF03153.13 CDI88068.1 - 0.041 13.9 24.7 0.058 13.4 24.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Coilin_N PF15862.5 CDI88068.1 - 0.046 13.5 10.6 0.086 12.6 10.6 1.4 1 0 0 1 1 1 0 Coilin N-terminus DDHD PF02862.17 CDI88068.1 - 0.13 12.4 5.7 0.18 11.9 5.7 1.2 1 0 0 1 1 1 0 DDHD domain AAA_23 PF13476.6 CDI88068.1 - 0.16 12.5 11.2 0.2 12.1 11.2 1.2 1 0 0 1 1 1 0 AAA domain EOS1 PF12326.8 CDI88068.1 - 0.26 11.2 1.1 0.31 10.9 1.1 1.2 1 0 0 1 1 1 0 N-glycosylation protein Serinc PF03348.15 CDI88068.1 - 0.39 9.6 1.4 0.46 9.4 1.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) LMBR1 PF04791.16 CDI88068.1 - 0.58 9.0 1.7 0.6 9.0 1.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Usp PF00582.26 CDI88068.1 - 0.8 10.2 2.5 1.8 9.1 2.5 1.5 1 0 0 1 1 1 0 Universal stress protein family Neur_chan_memb PF02932.16 CDI88068.1 - 1.2 9.1 5.9 1.7 8.7 5.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spt20 PF12090.8 CDI88068.1 - 1.5 8.4 35.6 2.4 7.7 35.6 1.2 1 0 0 1 1 1 0 Spt20 family Serpulina_VSP PF05540.11 CDI88068.1 - 1.7 7.6 5.6 0.77 8.7 3.0 1.6 2 0 0 2 2 2 0 Serpulina hyodysenteriae variable surface protein eIF-3_zeta PF05091.12 CDI88068.1 - 2.6 6.9 16.4 3.6 6.5 16.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RBM39linker PF15519.6 CDI88068.1 - 2.7 9.1 11.5 12 7.0 9.3 2.5 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein DUF1980 PF09323.10 CDI88068.1 - 3.9 7.4 7.5 6.2 6.7 7.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Connexin PF00029.19 CDI88068.1 - 5.3 6.7 12.4 7.8 6.2 12.4 1.2 1 0 0 1 1 1 0 Connexin Ureide_permease PF07168.11 CDI88068.1 - 5.6 5.6 7.7 7.3 5.2 7.7 1.1 1 0 0 1 1 1 0 Ureide permease Presenilin PF01080.17 CDI88068.1 - 8.3 5.1 13.5 12 4.6 13.5 1.1 1 0 0 1 1 1 0 Presenilin DDE_Tnp_Tn3 PF01526.17 CDI88069.1 - 0.05 12.4 10.3 0.077 11.8 10.3 1.3 1 0 0 1 1 1 0 Tn3 transposase DDE domain PIEZO PF15917.5 CDI88069.1 - 0.058 12.9 15.7 0.079 12.4 15.7 1.2 1 0 0 1 1 1 0 Piezo DDHD PF02862.17 CDI88069.1 - 0.15 12.2 8.5 0.19 11.9 8.5 1.1 1 0 0 1 1 1 0 DDHD domain MDM10 PF12519.8 CDI88069.1 - 0.17 10.7 6.6 0.2 10.5 6.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 UPF0560 PF10577.9 CDI88069.1 - 0.5 8.8 18.7 0.68 8.4 18.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 EIF4E-T PF10477.9 CDI88069.1 - 1.4 7.6 16.4 1.3 7.7 16.4 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E ALMT PF11744.8 CDI88069.1 - 2.2 7.0 8.3 2.5 6.8 8.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF966 PF06136.13 CDI88069.1 - 2.4 7.8 13.7 3 7.5 13.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) CTP_transf_3 PF02348.19 CDI88069.1 - 8.4 6.2 13.2 31 4.4 13.2 1.7 1 1 0 1 1 1 0 Cytidylyltransferase SR-25 PF10500.9 CDI88070.1 - 0.025 14.2 17.9 0.029 14.0 17.9 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SMYLE_N PF18615.1 CDI88070.1 - 0.42 10.1 17.5 0.49 9.9 17.5 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain SelP_N PF04592.14 CDI88070.1 - 0.5 9.7 26.1 0.69 9.3 26.1 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Macoilin PF09726.9 CDI88070.1 - 1.1 7.7 21.0 1.3 7.5 21.0 1.0 1 0 0 1 1 1 0 Macoilin family Plexin_cytopl PF08337.12 CDI88070.1 - 1.3 7.6 15.8 1.4 7.5 15.8 1.0 1 0 0 1 1 1 0 Plexin cytoplasmic RasGAP domain ASD2 PF08687.11 CDI88070.1 - 1.5 8.4 19.2 1.5 8.3 19.2 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 AAA_2 PF07724.14 CDI88070.1 - 1.8 8.6 10.3 5.9 7.0 10.3 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) IHABP4_N PF16174.5 CDI88070.1 - 1.8 9.1 18.7 2.3 8.8 18.7 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Sec62 PF03839.16 CDI88070.1 - 1.9 7.9 14.2 1.9 7.9 14.2 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 RskA PF10099.9 CDI88070.1 - 2 8.7 12.8 2.5 8.3 12.8 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA BAF1_ABF1 PF04684.13 CDI88070.1 - 2.2 7.2 20.3 2.3 7.2 20.3 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor TCP PF03634.13 CDI88070.1 - 2.4 8.7 19.9 3.2 8.3 19.9 1.2 1 0 0 1 1 1 0 TCP family transcription factor Dicty_REP PF05086.12 CDI88070.1 - 2.9 5.7 21.3 3.4 5.5 21.3 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TFIIA PF03153.13 CDI88070.1 - 3.3 7.6 42.0 3.6 7.5 42.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4569 PF15133.6 CDI88070.1 - 3.5 7.3 19.9 4.1 7.0 19.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Spore_coat_CotO PF14153.6 CDI88070.1 - 4.4 7.2 24.5 4.5 7.2 24.5 1.0 1 0 0 1 1 1 0 Spore coat protein CotO RR_TM4-6 PF06459.12 CDI88070.1 - 4.9 6.9 18.5 5.4 6.8 18.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Rtf2 PF04641.12 CDI88070.1 - 5 6.4 18.5 5.7 6.2 18.5 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger CCDC106 PF15794.5 CDI88070.1 - 5 6.8 20.2 5.7 6.6 20.2 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Nop53 PF07767.11 CDI88070.1 - 5.8 6.2 20.1 6.8 6.0 20.1 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) MMR1 PF08505.10 CDI88070.1 - 6.3 7.0 28.0 7.9 6.7 28.0 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF2052 PF09747.9 CDI88070.1 - 7.4 6.7 15.9 8.7 6.4 15.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Raftlin PF15250.6 CDI88070.1 - 7.9 5.1 19.3 9.1 4.9 19.3 1.0 1 0 0 1 1 1 0 Raftlin PNISR PF15996.5 CDI88070.1 - 8.1 6.7 21.5 9.8 6.4 21.5 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Neur_chan_memb PF02932.16 CDI88070.1 - 8.3 6.4 16.7 9.2 6.3 16.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hydin_ADK PF17213.3 CDI88070.1 - 8.9 6.5 22.5 13 6.0 22.5 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Spc7_N PF15402.6 CDI88070.1 - 9.8 4.3 23.0 11 4.1 23.0 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF4834 PF16118.5 CDI88071.1 - 0.0089 17.0 10.7 0.0093 16.9 10.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) DUF2828 PF11443.8 CDI88071.1 - 0.068 11.2 9.5 0.068 11.3 9.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) NEMP PF10225.9 CDI88071.1 - 0.075 12.7 5.8 0.082 12.6 5.8 1.0 1 0 0 1 1 1 0 NEMP family CLN3 PF02487.17 CDI88071.1 - 0.093 11.8 7.7 0.099 11.7 7.7 1.0 1 0 0 1 1 1 0 CLN3 protein EIIBC-GUT_N PF03612.14 CDI88071.1 - 0.11 12.2 8.7 0.12 12.1 8.7 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus SpoIIP PF07454.11 CDI88071.1 - 0.12 11.8 11.9 0.11 11.9 11.9 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) V_ATPase_I PF01496.19 CDI88071.1 - 0.13 10.2 12.3 0.13 10.1 12.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 CDI88071.1 - 0.13 11.0 11.1 0.14 10.9 11.1 1.0 1 0 0 1 1 1 0 Presenilin Orf78 PF06024.12 CDI88071.1 - 0.28 11.5 7.0 0.35 11.2 7.0 1.1 1 0 0 1 1 1 0 Orf78 (ac78) TFB6 PF17110.5 CDI88071.1 - 0.34 10.6 6.9 0.34 10.7 6.9 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH UPF0524 PF15823.5 CDI88071.1 - 0.38 10.1 6.0 0.41 10.0 6.0 1.1 1 0 0 1 1 1 0 UPF0524 of C3orf70 Dfp1_Him1_M PF08630.10 CDI88071.1 - 0.39 10.9 10.3 0.42 10.8 10.3 1.1 1 0 0 1 1 1 0 Dfp1/Him1, central region 7tm_2 PF00002.24 CDI88071.1 - 0.39 9.9 3.3 0.5 9.6 3.3 1.3 1 1 0 1 1 1 0 7 transmembrane receptor (Secretin family) OATP PF03137.20 CDI88071.1 - 0.44 8.8 5.3 0.49 8.6 5.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family 7tm_1 PF00001.21 CDI88071.1 - 0.45 9.8 2.1 0.54 9.5 2.1 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Folate_carrier PF01770.18 CDI88071.1 - 0.47 9.1 7.0 0.48 9.1 7.0 1.0 1 0 0 1 1 1 0 Reduced folate carrier RskA PF10099.9 CDI88071.1 - 0.49 10.7 6.6 0.62 10.3 6.6 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DDHD PF02862.17 CDI88071.1 - 0.56 10.3 9.3 0.54 10.4 9.3 1.0 1 0 0 1 1 1 0 DDHD domain CSG2 PF16965.5 CDI88071.1 - 0.61 9.0 7.8 0.64 8.9 7.8 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Connexin PF00029.19 CDI88071.1 - 0.7 9.6 7.5 0.69 9.6 7.5 1.1 1 0 0 1 1 1 0 Connexin DUF1980 PF09323.10 CDI88071.1 - 0.75 9.7 8.1 0.93 9.4 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) SID-1_RNA_chan PF13965.6 CDI88071.1 - 0.81 8.0 6.7 0.85 8.0 6.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 AIF_C PF14721.6 CDI88071.1 - 0.82 10.0 8.0 0.84 10.0 8.0 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TERB2 PF15101.6 CDI88071.1 - 0.99 9.4 17.7 0.97 9.4 17.7 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4407 PF14362.6 CDI88071.1 - 1 8.7 14.7 1 8.6 14.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMEM208_SND2 PF05620.11 CDI88071.1 - 1.2 8.9 8.4 1.4 8.7 8.4 1.1 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DUF2227 PF09988.9 CDI88071.1 - 1.2 9.0 2.7 1.3 8.9 2.7 1.1 1 0 0 1 1 1 0 Uncharacterized metal-binding protein (DUF2227) MMR1 PF08505.10 CDI88071.1 - 1.2 9.3 18.1 1.3 9.2 18.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Serinc PF03348.15 CDI88071.1 - 1.3 7.9 5.9 1.3 7.8 5.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Pex14_N PF04695.13 CDI88071.1 - 1.7 9.3 18.5 1.9 9.2 18.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ABC2_membrane_2 PF12679.7 CDI88071.1 - 1.8 7.8 7.2 1.9 7.7 7.2 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein EPL1 PF10513.9 CDI88071.1 - 1.9 8.9 18.1 2.1 8.7 18.1 1.0 1 0 0 1 1 1 0 Enhancer of polycomb-like EOS1 PF12326.8 CDI88071.1 - 1.9 8.4 5.0 2.2 8.2 5.0 1.1 1 0 0 1 1 1 0 N-glycosylation protein Ctr PF04145.15 CDI88071.1 - 2.1 8.9 5.2 2.1 9.0 5.2 1.1 1 0 0 1 1 1 0 Ctr copper transporter family TMEM51 PF15345.6 CDI88071.1 - 2.3 8.0 13.1 2.4 7.9 13.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Suf PF05843.14 CDI88071.1 - 2.4 8.1 16.2 2.5 8.0 16.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Rpp20 PF12328.8 CDI88071.1 - 2.4 8.1 10.8 2.6 8.0 10.8 1.1 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P eIF-3_zeta PF05091.12 CDI88071.1 - 2.5 7.0 16.0 2.4 7.0 16.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3464 PF11947.8 CDI88071.1 - 2.9 7.7 11.3 3.3 7.4 11.3 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF775 PF05603.12 CDI88071.1 - 3.3 7.2 17.2 3.9 7.0 17.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) FPN1 PF06963.12 CDI88071.1 - 4.1 5.9 7.1 4.2 5.8 7.1 1.0 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Glt_symporter PF03616.14 CDI88071.1 - 4.1 6.0 5.0 4.2 5.9 5.0 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter EMC3_TMCO1 PF01956.16 CDI88071.1 - 4.5 7.0 15.8 5.1 6.8 15.8 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Neur_chan_memb PF02932.16 CDI88071.1 - 4.9 7.1 8.6 5.3 7.0 8.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region UPF0560 PF10577.9 CDI88071.1 - 5.1 5.5 19.2 5.3 5.4 19.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Band_3_cyto PF07565.13 CDI88071.1 - 5.9 6.6 13.9 6.2 6.5 13.9 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Med15 PF09606.10 CDI88071.1 - 6.2 5.4 33.2 6.6 5.3 33.2 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal O-antigen_lig PF13425.6 CDI88071.1 - 6.2 5.5 6.9 6.4 5.4 6.9 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Ureide_permease PF07168.11 CDI88071.1 - 6.3 5.4 6.3 6 5.5 6.3 1.1 1 0 0 1 1 1 0 Ureide permease Kei1 PF08552.11 CDI88071.1 - 6.6 6.6 7.7 7.5 6.4 7.7 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 TFIIA PF03153.13 CDI88071.1 - 7.9 6.4 34.7 8.1 6.3 34.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TFIIA PF03153.13 CDI88072.1 - 0.21 11.6 49.4 0.28 11.1 49.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zip PF02535.22 CDI88072.1 - 0.41 9.8 3.8 0.48 9.6 3.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 CDI88072.1 - 0.59 10.1 12.9 0.72 9.9 12.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MDM31_MDM32 PF08118.11 CDI88072.1 - 0.85 8.2 6.1 1.2 7.7 6.1 1.3 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF4638 PF15472.6 CDI88072.1 - 1.4 8.6 9.0 1.6 8.4 9.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF45 PF01863.17 CDI88072.1 - 1.9 8.5 11.9 2.4 8.1 11.9 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF45 Connexin PF00029.19 CDI88072.1 - 2.2 8.0 5.7 3.4 7.3 5.7 1.3 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 CDI88072.1 - 3.4 5.5 11.9 3.9 5.3 11.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SLC12 PF03522.15 CDI88072.1 - 3.8 6.4 13.3 4.1 6.3 13.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF2052 PF09747.9 CDI88072.1 - 4.7 7.3 17.4 6 6.9 17.4 1.3 1 1 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SWI-SNF_Ssr4 PF08549.10 CDI88072.1 - 6.3 5.3 24.9 7.5 5.1 24.9 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) CCSAP PF15748.5 CDI88072.1 - 7.9 6.6 19.0 9.5 6.3 19.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated ketoacyl-synt PF00109.26 CDI88073.1 - 2.3e-43 148.6 0.0 2.8e-43 148.3 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Spore_coat_CotO PF14153.6 CDI88074.1 - 0.63 9.9 16.1 0.81 9.6 16.1 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DUF5061 PF16587.5 CDI88074.1 - 0.78 9.8 5.8 0.76 9.9 1.5 2.3 1 1 1 2 2 2 0 17 kDa common-antigen outer membrane protein TFIIA PF03153.13 CDI88074.1 - 4.8 7.1 23.7 5.2 7.0 23.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI88074.1 - 6.5 4.9 16.4 6.4 4.9 16.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 HCV_NS4b PF01001.19 CDI88075.1 - 0.0098 15.5 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 1 Hepatitis C virus non-structural protein NS4b PAT1 PF09770.9 CDI88075.1 - 0.54 8.5 35.8 0.61 8.3 35.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.10 CDI88075.1 - 0.97 8.0 53.2 1.2 7.7 53.2 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Presenilin PF01080.17 CDI88075.1 - 5.3 5.7 15.6 6.7 5.4 15.6 1.2 1 0 0 1 1 1 0 Presenilin GAGA_bind PF06217.12 CDI88075.1 - 5.3 7.2 16.8 7.2 6.8 16.8 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family Trp_oprn_chp PF09534.10 CDI88076.1 - 0.0019 18.1 1.6 0.0022 17.8 1.6 1.1 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) RskA PF10099.9 CDI88076.1 - 0.0021 18.4 10.7 0.0026 18.1 10.7 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF5134 PF17197.4 CDI88076.1 - 0.0043 17.0 0.1 0.0055 16.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5134) DUF898 PF05987.13 CDI88076.1 - 0.0046 16.1 0.2 0.0053 15.9 0.2 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF898) OPA3 PF07047.12 CDI88076.1 - 0.038 13.8 6.0 0.78 9.5 1.3 2.1 2 0 0 2 2 2 0 Optic atrophy 3 protein (OPA3) Tau95_N PF17682.1 CDI88076.1 - 0.043 14.0 0.9 0.043 14.0 0.9 2.0 1 1 1 2 2 2 0 Tau95 Triple barrel domain INSIG PF07281.12 CDI88076.1 - 0.069 12.8 5.0 0.086 12.5 5.0 1.2 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) DUF2270 PF10028.9 CDI88076.1 - 0.11 12.1 3.3 0.14 11.7 3.3 1.1 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2270) Glucodextran_C PF09985.9 CDI88076.1 - 0.13 11.7 7.4 0.16 11.4 7.4 1.2 1 0 0 1 1 1 0 C-terminal binding-module, SLH-like, of glucodextranase DUF3357 PF11837.8 CDI88076.1 - 0.15 12.5 5.3 0.19 12.2 2.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) DUF4366 PF14283.6 CDI88076.1 - 0.2 11.7 4.2 0.35 10.9 4.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) CcmH PF03918.14 CDI88076.1 - 0.21 10.9 13.0 0.039 13.2 2.6 2.2 1 1 1 2 2 2 0 Cytochrome C biogenesis protein DUF3742 PF12553.8 CDI88076.1 - 0.23 11.6 3.6 0.37 10.9 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3742) Presenilin PF01080.17 CDI88076.1 - 0.25 10.1 12.6 0.3 9.8 12.6 1.2 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 CDI88076.1 - 0.31 10.0 9.3 0.36 9.8 9.3 1.1 1 0 0 1 1 1 0 CLN3 protein Sulf_transp PF04143.14 CDI88076.1 - 0.32 10.5 2.0 0.36 10.3 2.0 1.0 1 0 0 1 1 1 0 Sulphur transport PIRT PF15099.6 CDI88076.1 - 0.35 10.5 2.8 1.1 8.9 2.8 1.8 1 1 0 1 1 1 0 Phosphoinositide-interacting protein family DUF2489 PF10675.9 CDI88076.1 - 0.56 10.1 26.7 1.8 8.5 13.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) CAF1 PF04857.20 CDI88076.1 - 0.81 8.8 8.1 1.1 8.3 8.1 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease EphA2_TM PF14575.6 CDI88076.1 - 0.87 10.5 15.7 2.3 9.2 2.6 2.5 1 1 2 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain MAT1 PF06391.13 CDI88076.1 - 1.2 8.9 21.1 1.5 8.6 21.1 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 O-antigen_lig PF13425.6 CDI88076.1 - 1.2 7.8 4.5 1.5 7.5 4.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF2140 PF09911.9 CDI88076.1 - 1.3 8.5 9.7 0.85 9.1 2.3 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF4079 PF13301.6 CDI88076.1 - 2.4 8.3 12.3 1.1 9.4 3.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) TMEM208_SND2 PF05620.11 CDI88076.1 - 2.9 7.6 14.6 0.84 9.4 4.3 2.1 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Spt20 PF12090.8 CDI88076.1 - 3.2 7.3 47.7 1.9 8.0 15.5 2.0 2 0 0 2 2 2 0 Spt20 family ALMT PF11744.8 CDI88076.1 - 3.2 6.5 12.5 3.8 6.2 12.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Conotoxin PF02950.17 CDI88076.1 - 3.3 8.8 18.4 0.15 13.1 3.5 2.4 1 1 1 2 2 2 0 Conotoxin XRN_N PF03159.18 CDI88076.1 - 4.5 6.6 16.4 8.8 5.7 16.4 1.5 1 1 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus DUF3169 PF11368.8 CDI88076.1 - 4.7 6.7 5.3 4.3 6.8 0.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) PDGF_N PF04692.13 CDI88076.1 - 4.9 8.0 15.6 11 6.9 6.7 2.1 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region CSG2 PF16965.5 CDI88076.1 - 5.2 5.9 9.8 5.4 5.9 9.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator eIF_4EBP PF05456.11 CDI88076.1 - 6.3 6.8 11.9 3.5 7.6 0.8 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) DUF4064 PF13273.6 CDI88076.1 - 8.4 6.7 8.3 2.9e+02 1.8 8.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) CitMHS_2 PF16980.5 CDI88076.1 - 9 4.8 6.9 2 7.0 0.3 1.9 1 1 1 2 2 2 0 Putative citrate transport DUF4175 PF13779.6 CDI88076.1 - 9.3 4.0 32.5 12 3.7 32.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Presenilin PF01080.17 CDI88077.1 - 6.9 5.3 8.1 7.8 5.1 8.1 1.0 1 0 0 1 1 1 0 Presenilin YqzL PF14006.6 CDI88078.1 - 0.037 14.4 3.1 0.037 14.4 3.1 3.2 1 1 1 2 2 1 0 YqzL-like protein RPN2_C PF18004.1 CDI88078.1 - 0.039 13.9 14.9 0.051 13.5 14.9 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Velvet PF11754.8 CDI88078.1 - 0.1 12.5 16.0 0.11 12.5 16.0 1.0 1 0 0 1 1 1 0 Velvet factor DUF2407_C PF13373.6 CDI88078.1 - 0.13 12.4 13.1 0.16 12.1 13.1 1.1 1 0 0 1 1 1 0 DUF2407 C-terminal domain Afi1 PF07792.12 CDI88078.1 - 0.15 12.5 16.6 0.2 12.1 16.6 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking tRNA_synt_1c_R2 PF04557.15 CDI88078.1 - 0.15 13.0 13.3 2.1 9.3 10.9 2.0 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 CNDH2_C PF16858.5 CDI88078.1 - 0.15 11.9 22.9 0.19 11.6 22.9 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term V_ATPase_I PF01496.19 CDI88078.1 - 0.16 9.8 22.4 0.19 9.6 22.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CCDC53 PF10152.9 CDI88078.1 - 0.2 12.1 19.9 0.25 11.8 19.9 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF572 PF04502.13 CDI88078.1 - 0.22 11.1 16.1 0.26 10.9 16.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Saw1 PF11561.8 CDI88078.1 - 0.25 10.8 16.4 0.26 10.8 16.4 1.0 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Gti1_Pac2 PF09729.9 CDI88078.1 - 0.33 11.0 14.7 0.4 10.7 14.7 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF2347 PF09804.9 CDI88078.1 - 0.37 10.3 16.3 0.4 10.2 16.3 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Presenilin PF01080.17 CDI88078.1 - 0.56 8.9 23.7 0.67 8.6 23.7 1.0 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 CDI88078.1 - 0.59 9.1 14.1 0.71 8.9 14.1 1.1 1 0 0 1 1 1 0 CLN3 protein DUF913 PF06025.12 CDI88078.1 - 0.64 8.9 10.5 0.77 8.7 10.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) eIF-3_zeta PF05091.12 CDI88078.1 - 0.9 8.4 26.5 1.1 8.2 26.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Band_3_cyto PF07565.13 CDI88078.1 - 1.1 9.0 18.7 1.4 8.7 18.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Paf1 PF03985.13 CDI88078.1 - 1.1 8.1 22.3 1.4 7.8 22.3 1.1 1 0 0 1 1 1 0 Paf1 RR_TM4-6 PF06459.12 CDI88078.1 - 1.1 9.0 20.4 1.4 8.7 20.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CSG2 PF16965.5 CDI88078.1 - 1.2 8.0 9.8 1.2 8.0 9.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator FAM60A PF15396.6 CDI88078.1 - 1.4 8.9 16.1 1.6 8.7 16.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A BORG_CEP PF14957.6 CDI88078.1 - 1.9 9.6 13.5 2.3 9.4 13.5 1.1 1 0 0 1 1 1 0 Cdc42 effector SLC12 PF03522.15 CDI88078.1 - 2 7.3 21.0 2.4 7.1 21.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI88078.1 - 2.4 8.2 16.6 2.9 7.9 16.6 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2828 PF11443.8 CDI88078.1 - 2.6 6.0 18.1 2.8 5.9 18.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Spore_coat_CotO PF14153.6 CDI88078.1 - 2.7 7.9 28.5 3.3 7.6 28.5 1.1 1 0 0 1 1 1 0 Spore coat protein CotO DUF2126 PF09899.9 CDI88078.1 - 2.9 5.9 14.6 3.2 5.7 14.6 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF2076 PF09849.9 CDI88078.1 - 3.2 7.7 42.9 3.7 7.5 42.9 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Cellulose_synt PF03552.14 CDI88078.1 - 4.9 5.5 8.6 4.9 5.5 8.6 1.0 1 0 0 1 1 1 0 Cellulose synthase HCO3_cotransp PF00955.21 CDI88078.1 - 5.7 5.7 9.7 6.2 5.5 9.7 1.0 1 0 0 1 1 1 0 HCO3- transporter family Dapper PF15268.6 CDI88078.1 - 6.1 5.6 26.1 6.9 5.4 26.1 1.0 1 0 0 1 1 1 0 Dapper Ten_N PF06484.12 CDI88078.1 - 7.4 6.3 12.4 8.2 6.2 12.4 1.0 1 0 0 1 1 1 0 Teneurin Intracellular Region PAT1 PF09770.9 CDI88078.1 - 8.5 4.5 36.6 9.9 4.3 36.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2813 PF11398.8 CDI88078.1 - 8.9 5.5 24.6 9.8 5.3 24.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) ALMT PF11744.8 CDI88078.1 - 9.3 5.0 17.0 11 4.7 17.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DDRGK PF09756.9 CDI88078.1 - 9.7 5.7 32.2 14 5.2 32.2 1.2 1 0 0 1 1 1 0 DDRGK domain eIF-3_zeta PF05091.12 CDI88079.1 - 0.00022 20.4 12.2 0.00022 20.4 12.2 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Suf PF05843.14 CDI88079.1 - 0.00064 19.8 15.0 0.00069 19.7 15.0 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) DUF3464 PF11947.8 CDI88079.1 - 0.00082 19.2 7.9 0.0014 18.4 7.9 1.5 1 0 0 1 1 1 1 Photosynthesis affected mutant 68 FAM60A PF15396.6 CDI88079.1 - 0.00096 19.2 6.2 0.0012 18.9 6.2 1.1 1 0 0 1 1 1 1 Protein Family FAM60A MecA PF05389.12 CDI88079.1 - 0.0018 18.0 3.8 0.0018 18.0 3.8 1.1 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) Connexin PF00029.19 CDI88079.1 - 0.002 18.0 4.1 0.0021 17.8 4.1 1.2 1 0 0 1 1 1 1 Connexin Eapp_C PF10238.9 CDI88079.1 - 0.0029 17.7 15.7 0.0029 17.7 15.7 1.4 2 0 0 2 2 1 1 E2F-associated phosphoprotein PRP1_N PF06424.12 CDI88079.1 - 0.003 18.0 8.2 0.0043 17.5 8.2 1.2 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal Velvet PF11754.8 CDI88079.1 - 0.0033 17.4 12.2 0.0033 17.4 12.2 1.1 1 0 0 1 1 1 1 Velvet factor SpoIIP PF07454.11 CDI88079.1 - 0.0039 16.7 11.8 0.0046 16.5 11.8 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) DUF2235 PF09994.9 CDI88079.1 - 0.0045 16.4 3.3 0.0059 16.0 3.3 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) EOS1 PF12326.8 CDI88079.1 - 0.0072 16.3 2.8 0.0079 16.1 2.8 1.2 1 0 0 1 1 1 1 N-glycosylation protein CSG2 PF16965.5 CDI88079.1 - 0.0094 14.9 4.2 0.0099 14.9 4.2 1.1 1 0 0 1 1 1 1 Ceramide synthase regulator TFIIA PF03153.13 CDI88079.1 - 0.01 15.8 39.9 0.012 15.6 39.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4770 PF15994.5 CDI88079.1 - 0.014 15.6 12.0 0.018 15.3 12.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Tim54 PF11711.8 CDI88079.1 - 0.015 14.1 8.2 0.016 14.0 8.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PPL5 PF18168.1 CDI88079.1 - 0.017 14.5 4.3 0.018 14.3 4.3 1.2 1 0 0 1 1 1 0 Prim-pol family 5 PAT1 PF09770.9 CDI88079.1 - 0.017 13.4 22.6 0.017 13.4 22.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 V_ATPase_I PF01496.19 CDI88079.1 - 0.018 13.0 10.7 0.019 12.9 10.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 CDI88079.1 - 0.018 13.3 5.9 0.018 13.4 5.9 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF572 PF04502.13 CDI88079.1 - 0.019 14.6 15.4 0.022 14.4 15.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Thioredoxin_9 PF14595.6 CDI88079.1 - 0.019 14.7 6.8 0.027 14.3 6.8 1.2 1 0 0 1 1 1 0 Thioredoxin Presenilin PF01080.17 CDI88079.1 - 0.024 13.4 16.7 0.026 13.3 16.7 1.1 1 0 0 1 1 1 0 Presenilin Endostatin PF06482.11 CDI88079.1 - 0.026 14.0 11.2 0.029 13.8 11.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin OATP PF03137.20 CDI88079.1 - 0.026 12.8 3.9 0.031 12.6 3.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4175 PF13779.6 CDI88079.1 - 0.026 12.4 29.6 0.028 12.4 29.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF2828 PF11443.8 CDI88079.1 - 0.029 12.5 9.6 0.032 12.3 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) TFB6 PF17110.5 CDI88079.1 - 0.036 13.8 5.4 0.043 13.6 5.4 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH SID-1_RNA_chan PF13965.6 CDI88079.1 - 0.049 12.0 3.2 0.047 12.1 3.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 MMR1 PF08505.10 CDI88079.1 - 0.051 13.9 17.3 0.056 13.7 17.3 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein TCP PF03634.13 CDI88079.1 - 0.054 14.1 13.9 0.069 13.7 13.9 1.1 1 0 0 1 1 1 0 TCP family transcription factor LMBR1 PF04791.16 CDI88079.1 - 0.058 12.3 3.1 0.055 12.4 3.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein SLC12 PF03522.15 CDI88079.1 - 0.063 12.3 10.9 0.061 12.3 10.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 CDI88079.1 - 0.066 13.0 12.7 0.073 12.9 12.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 CDI88079.1 - 0.067 13.4 11.8 0.078 13.1 11.8 1.2 1 0 0 1 1 1 0 DDHD domain EIF4E-T PF10477.9 CDI88079.1 - 0.07 11.9 17.7 0.077 11.8 17.7 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E CLN3 PF02487.17 CDI88079.1 - 0.073 12.1 8.1 0.087 11.9 8.1 1.1 1 0 0 1 1 1 0 CLN3 protein Methyltransf_12 PF08242.12 CDI88079.1 - 0.1 13.4 4.9 0.19 12.5 4.9 1.6 1 1 0 1 1 1 0 Methyltransferase domain Lin-8 PF03353.15 CDI88079.1 - 0.1 12.1 14.7 0.11 12.0 14.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF913 PF06025.12 CDI88079.1 - 0.1 11.5 6.5 0.11 11.5 6.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 CDI88079.1 - 0.12 11.6 6.2 0.15 11.3 6.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Het-C PF07217.11 CDI88079.1 - 0.14 10.6 7.5 0.15 10.6 7.5 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C CCSAP PF15748.5 CDI88079.1 - 0.16 12.1 16.2 0.19 11.9 16.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated EMC3_TMCO1 PF01956.16 CDI88079.1 - 0.18 11.6 10.6 0.21 11.3 10.6 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Neur_chan_memb PF02932.16 CDI88079.1 - 0.18 11.8 9.7 0.21 11.6 9.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1980 PF09323.10 CDI88079.1 - 0.18 11.7 9.3 0.23 11.3 9.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) ALMT PF11744.8 CDI88079.1 - 0.19 10.5 8.5 0.21 10.4 8.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter 2HCT PF03390.15 CDI88079.1 - 0.22 10.1 2.1 0.23 10.0 2.1 1.3 1 1 0 1 1 1 0 2-hydroxycarboxylate transporter family DUF4638 PF15472.6 CDI88079.1 - 0.23 11.2 9.0 0.25 11.0 9.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) LAP1C PF05609.12 CDI88079.1 - 0.23 10.5 15.3 0.25 10.4 15.3 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Serinc PF03348.15 CDI88079.1 - 0.24 10.3 6.8 0.25 10.2 6.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Folate_carrier PF01770.18 CDI88079.1 - 0.3 9.8 6.9 0.36 9.5 6.9 1.1 1 0 0 1 1 1 0 Reduced folate carrier Glt_symporter PF03616.14 CDI88079.1 - 0.3 9.7 4.5 0.41 9.3 4.5 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter DUF2126 PF09899.9 CDI88079.1 - 0.36 8.9 10.2 0.42 8.6 10.2 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) TMEM51 PF15345.6 CDI88079.1 - 0.41 10.4 20.1 0.075 12.9 15.5 1.8 2 0 0 2 2 2 0 Transmembrane protein 51 DUF4746 PF15928.5 CDI88079.1 - 0.42 10.0 9.3 0.49 9.8 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) NARP1 PF12569.8 CDI88079.1 - 0.55 9.1 12.1 0.63 8.9 12.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FAM176 PF14851.6 CDI88079.1 - 0.58 9.8 8.5 0.89 9.2 8.5 1.2 1 0 0 1 1 1 0 FAM176 family Baculo_PP31 PF05311.11 CDI88079.1 - 0.58 9.6 13.2 0.7 9.3 13.2 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Sec62 PF03839.16 CDI88079.1 - 0.64 9.5 8.3 0.74 9.3 8.3 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 HemX PF04375.14 CDI88079.1 - 0.67 9.2 27.4 0.75 9.0 27.4 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase SprA-related PF12118.8 CDI88079.1 - 0.67 9.0 32.4 0.88 8.6 32.4 1.2 1 0 0 1 1 1 0 SprA-related family Band_3_cyto PF07565.13 CDI88079.1 - 0.68 9.7 13.7 0.84 9.4 13.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain UPF0560 PF10577.9 CDI88079.1 - 0.71 8.3 21.9 0.8 8.1 21.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF853 PF05872.12 CDI88079.1 - 0.76 8.3 10.0 0.77 8.3 10.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) HCO3_cotransp PF00955.21 CDI88079.1 - 0.79 8.5 3.9 0.85 8.4 3.9 1.1 1 0 0 1 1 1 0 HCO3- transporter family PIP5K PF01504.18 CDI88079.1 - 0.93 8.7 12.5 1.3 8.2 12.5 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF3984 PF13136.6 CDI88079.1 - 1 8.7 14.8 1.4 8.3 14.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) AF-4 PF05110.13 CDI88079.1 - 1.1 7.3 21.6 1.2 7.2 21.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Peptidase_S49_N PF08496.10 CDI88079.1 - 1.1 9.3 11.3 1.6 8.7 11.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MDM10 PF12519.8 CDI88079.1 - 1.2 7.9 11.7 1.4 7.7 11.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 eIF_4EBP PF05456.11 CDI88079.1 - 1.2 9.1 13.2 2.1 8.3 13.2 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) PRC2_HTH_1 PF18118.1 CDI88079.1 - 1.5 9.7 12.8 1 10.2 11.3 1.5 2 0 0 2 2 1 0 Polycomb repressive complex 2 tri-helical domain GREB1 PF15782.5 CDI88079.1 - 1.5 5.9 18.9 1.5 5.8 18.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MPM1 PF17234.2 CDI88079.1 - 1.9 8.7 16.4 3 8.1 16.4 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 AUX_IAA PF02309.16 CDI88079.1 - 2 8.2 9.7 2.2 8.1 9.7 1.2 1 0 0 1 1 1 0 AUX/IAA family Paramyxo_ncap PF00973.19 CDI88079.1 - 2.1 7.2 8.7 2.2 7.1 8.7 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein AAA_23 PF13476.6 CDI88079.1 - 2.2 8.7 16.5 2.6 8.5 16.5 1.1 1 0 0 1 1 1 0 AAA domain Nucleoside_tran PF01733.18 CDI88079.1 - 2.8 7.2 4.9 3.4 7.0 4.9 1.1 1 0 0 1 1 1 0 Nucleoside transporter MDM31_MDM32 PF08118.11 CDI88079.1 - 3.2 6.3 10.4 4 6.0 10.4 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins MAJIN PF15077.6 CDI88079.1 - 3.2 7.5 11.5 3.7 7.3 11.5 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein DDRGK PF09756.9 CDI88079.1 - 3.2 7.3 21.3 4.5 6.8 21.3 1.1 1 0 0 1 1 1 0 DDRGK domain Paf1 PF03985.13 CDI88079.1 - 3.5 6.5 17.6 4.1 6.3 17.6 1.1 1 0 0 1 1 1 0 Paf1 Ureide_permease PF07168.11 CDI88079.1 - 3.6 6.2 6.4 5.2 5.7 6.4 1.2 1 0 0 1 1 1 0 Ureide permease MTP18 PF10558.9 CDI88079.1 - 4.3 7.3 9.5 5.9 6.8 9.5 1.2 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) RskA PF10099.9 CDI88079.1 - 4.8 7.5 27.3 22 5.3 27.3 1.8 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Hid1 PF12722.7 CDI88079.1 - 4.8 5.2 16.8 5 5.1 16.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein O-antigen_lig PF13425.6 CDI88079.1 - 5.8 5.6 6.2 6.3 5.5 6.2 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein TERB2 PF15101.6 CDI88079.1 - 6.1 6.8 23.9 8.7 6.3 23.9 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Pal1 PF08316.11 CDI88079.1 - 6.2 7.6 12.2 8.9 7.1 12.2 1.5 1 1 0 1 1 1 0 Pal1 cell morphology protein Ribosomal_60s PF00428.19 CDI88079.1 - 6.7 7.4 11.7 18 6.0 11.7 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein FliP PF00813.20 CDI88079.1 - 7.3 6.4 6.2 9 6.1 6.2 1.1 1 0 0 1 1 1 0 FliP family Nha1_C PF08619.10 CDI88079.1 - 7.5 5.6 22.6 8.7 5.4 22.6 1.0 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Ndc1_Nup PF09531.10 CDI88079.1 - 9.3 4.8 16.7 9.8 4.7 16.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4199 PF13858.6 CDI88079.1 - 10 6.5 7.7 15 6.0 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) MAPEG PF01124.18 CDI88080.1 - 0.099 12.5 2.1 0.18 11.7 2.1 1.5 1 0 0 1 1 1 0 MAPEG family FAM199X PF15814.5 CDI88080.1 - 0.22 10.5 25.9 0.28 10.2 25.9 1.1 1 0 0 1 1 1 0 Protein family FAM199X BSP_II PF05432.11 CDI88080.1 - 0.63 9.7 24.3 0.81 9.3 24.3 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) SOBP PF15279.6 CDI88080.1 - 0.92 10.1 34.6 1.2 9.7 34.6 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF3439 PF11921.8 CDI88080.1 - 1.4 8.9 17.8 0.58 10.1 15.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3439) AF-4 PF05110.13 CDI88080.1 - 1.5 6.8 46.1 1.9 6.5 46.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF2232 PF09991.9 CDI88080.1 - 1.5 7.9 3.9 2.2 7.4 3.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) SprA-related PF12118.8 CDI88080.1 - 1.6 7.8 49.1 2.2 7.3 49.1 1.1 1 0 0 1 1 1 0 SprA-related family LAP1C PF05609.12 CDI88080.1 - 4.1 6.4 39.1 4.6 6.2 39.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RAP1 PF07218.11 CDI88080.1 - 5.2 5.2 17.0 5.9 5.0 17.0 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DDRGK PF09756.9 CDI88080.1 - 6 6.4 20.6 1 8.9 14.0 2.0 2 0 0 2 2 2 0 DDRGK domain BAF1_ABF1 PF04684.13 CDI88080.1 - 8.4 5.3 40.0 11 4.9 40.0 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Utp14 PF04615.13 CDI88080.1 - 9 4.7 35.2 11 4.4 35.2 1.0 1 0 0 1 1 1 0 Utp14 protein Lin-8 PF03353.15 CDJ26837.1 - 6e-05 22.8 26.8 6e-05 22.8 26.8 3.8 3 1 1 4 4 4 2 Ras-mediated vulval-induction antagonist Cwf_Cwc_15 PF04889.12 CDJ26837.1 - 0.00015 21.6 19.4 0.00015 21.6 19.4 3.8 3 1 0 4 4 4 1 Cwf15/Cwc15 cell cycle control protein TMEM51 PF15345.6 CDJ26837.1 - 0.0012 18.7 9.1 0.0012 18.7 9.1 5.1 4 2 1 5 5 3 1 Transmembrane protein 51 Vfa1 PF08432.10 CDJ26837.1 - 0.0056 17.0 16.5 0.0056 17.0 16.5 4.0 3 1 1 4 4 4 1 AAA-ATPase Vps4-associated protein 1 N6_N4_Mtase PF01555.18 CDJ26837.1 - 0.0076 16.0 0.0 0.27 10.9 0.0 3.2 2 1 0 2 2 2 1 DNA methylase NPR3 PF03666.13 CDJ26837.1 - 0.075 11.8 41.7 0.025 13.4 23.2 3.4 3 0 0 3 3 3 0 Nitrogen Permease regulator of amino acid transport activity 3 CLN3 PF02487.17 CDJ26837.1 - 0.36 9.8 35.6 0.66 8.9 4.2 3.5 3 0 0 3 3 3 0 CLN3 protein V_ATPase_I PF01496.19 CDJ26837.1 - 0.4 8.5 47.6 0.22 9.4 25.4 3.3 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family SID-1_RNA_chan PF13965.6 CDJ26837.1 - 0.56 8.5 19.6 0.26 9.6 6.3 3.1 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 Apt1 PF10351.9 CDJ26837.1 - 0.87 8.4 43.0 0.71 8.7 22.2 3.2 3 0 0 3 3 3 0 Golgi-body localisation protein domain SDA1 PF05285.12 CDJ26837.1 - 1.2 8.5 42.9 0.046 13.2 25.1 2.3 2 0 0 2 2 2 0 SDA1 Peptidase_S49_N PF08496.10 CDJ26837.1 - 1.4 8.9 45.4 0.69 10.0 6.5 4.0 4 0 0 4 4 4 0 Peptidase family S49 N-terminal SARAF PF06682.12 CDJ26838.1 - 0.19 11.4 9.7 0.2 11.2 9.7 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Nop53 PF07767.11 CDJ26838.1 - 0.83 9.0 43.7 1 8.7 43.7 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.14 CDJ26838.1 - 1.7 6.8 33.6 1.9 6.7 33.6 1.0 1 0 0 1 1 1 0 CDC45-like protein PA26 PF04636.13 CDJ26838.1 - 4.5 6.1 20.5 4.7 6.0 20.5 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Hydin_ADK PF17213.3 CDJ26838.1 - 5.5 7.2 20.2 6.4 7.0 20.2 1.0 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain RskA PF10099.9 CDJ26839.1 - 0.00087 19.6 18.5 0.0012 19.2 18.5 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Shadoo PF14999.6 CDJ26839.1 - 0.004 17.2 2.9 0.0048 17.0 2.9 1.1 1 0 0 1 1 1 1 Shadow of prion protein, neuroprotective CD20 PF04103.15 CDJ26839.1 - 0.0081 16.3 0.6 0.0081 16.3 0.6 1.9 2 0 0 2 2 2 1 CD20-like family DUF4820 PF16091.5 CDJ26839.1 - 0.012 15.0 0.9 0.013 14.9 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) FHIPEP PF00771.20 CDJ26839.1 - 0.016 13.7 1.6 0.014 13.9 1.6 1.0 1 0 0 1 1 1 0 FHIPEP family Zip PF02535.22 CDJ26839.1 - 0.02 14.1 3.6 0.025 13.8 3.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Connexin PF00029.19 CDJ26839.1 - 0.022 14.5 0.5 0.022 14.5 0.5 1.2 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 CDJ26839.1 - 0.028 13.2 3.7 0.031 13.0 3.7 1.2 1 0 0 1 1 1 0 Presenilin LCE PF14672.6 CDJ26839.1 - 0.03 14.9 4.0 0.03 14.9 4.0 1.9 2 0 0 2 2 2 0 Late cornified envelope Spt20 PF12090.8 CDJ26839.1 - 0.031 13.9 17.3 0.032 13.8 17.3 1.1 1 0 0 1 1 1 0 Spt20 family TYW3 PF02676.14 CDJ26839.1 - 0.031 13.6 2.0 0.036 13.4 2.0 1.0 1 0 0 1 1 1 0 Methyltransferase TYW3 DUF202 PF02656.15 CDJ26839.1 - 0.042 14.3 0.7 0.059 13.8 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Ctr PF04145.15 CDJ26839.1 - 0.045 14.4 1.0 0.059 14.0 1.0 1.2 1 0 0 1 1 1 0 Ctr copper transporter family DUF4179 PF13786.6 CDJ26839.1 - 0.094 13.2 0.4 0.094 13.2 0.4 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF4179) DUF3984 PF13136.6 CDJ26839.1 - 0.11 11.9 8.6 0.11 11.9 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) FAM199X PF15814.5 CDJ26839.1 - 0.13 11.3 5.2 0.15 11.1 5.2 1.1 1 0 0 1 1 1 0 Protein family FAM199X Neur_chan_memb PF02932.16 CDJ26839.1 - 0.15 12.0 2.4 0.15 12.1 2.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SelP_N PF04592.14 CDJ26839.1 - 0.21 11.0 19.3 0.25 10.7 19.3 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Kei1 PF08552.11 CDJ26839.1 - 0.29 11.0 6.9 0.34 10.8 6.9 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 NUDE_C PF04880.13 CDJ26839.1 - 0.3 11.5 8.1 0.34 11.4 8.1 1.1 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region CLN3 PF02487.17 CDJ26839.1 - 0.35 9.9 2.1 0.38 9.7 2.1 1.2 1 0 0 1 1 1 0 CLN3 protein DUF4834 PF16118.5 CDJ26839.1 - 1.4 9.9 8.5 1.8 9.6 8.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Coilin_N PF15862.5 CDJ26839.1 - 1.9 8.3 10.7 2.4 8.0 10.7 1.1 1 0 0 1 1 1 0 Coilin N-terminus TFIIA PF03153.13 CDJ26839.1 - 2.2 8.2 25.7 2.3 8.1 25.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2512 PF10710.9 CDJ26839.1 - 3.4 7.3 10.0 8.9 6.0 5.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2512) R_equi_Vir PF05526.11 CDJ26839.1 - 3.8 7.4 11.0 4.5 7.1 11.0 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF3464 PF11947.8 CDJ26839.1 - 4.2 7.1 6.3 6.3 6.5 6.3 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 eIF3_subunit PF08597.10 CDJ26839.1 - 5.8 6.8 14.6 7.2 6.4 14.6 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit AIF_C PF14721.6 CDJ26839.1 - 9 6.7 9.8 11 6.4 9.8 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF3138 PF11336.8 CDJ26839.1 - 10 4.6 11.2 12 4.4 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Eimeria_praecox-EPH001/GCA_000499445.1_EPH001_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Eimeria_praecox-EPH001/GCA_000499445.1_EPH001_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Eimeria_praecox-EPH001/GCA_000499445.1_EPH001_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Eimeria_praecox-EPH001/GCA_000499445.1_EPH001_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 02:00:31 2019 # [ok]